id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000660-tsvzg0ax	Fensterl, Volker	Interferon-Induced Ifit2/ISG54 Protects Mice from Lethal VSV Neuropathogenesis	2012-05-17		.txt	text/plain	8283	446	55	Interferon protects mice from vesicular stomatitis virus (VSV) infection and pathogenesis; however, it is not known which of the numerous interferon-stimulated genes (ISG) mediate the antiviral effect. In contrast, in acute infection by viruses that cause severe pathogenesis and death within a few days after infection, protection is primarily provided by the intrinsic antiviral actions of IFN-induced proteins encoded by the hundreds of IFN-stimulated genes (ISGs) [10] [11] [12] , several of which often contribute to the overall effect of IFN against a given virus. From the above observations, we conclude that after intranasal infection by VSV, Ifit2 protects mice from neuropathogenesis by suppressing replication or spread of the virus in brain neurons. In the complete absence of type I IFN action in the IFNAR 2/2 mice, intranasally infected VSV replicated vigorously not only in brains, but also in livers and lungs ( Figure 7A-C) .	./cache/cord-000660-tsvzg0ax.txt	./txt/cord-000660-tsvzg0ax.txt