id sid tid token lemma pos cord-339015-qn8wbnlw 1 1 key key JJ cord-339015-qn8wbnlw 1 2 : : : cord-339015-qn8wbnlw 1 3 cord-339015-qn8wbnlw cord-339015-qn8wbnlw CD cord-339015-qn8wbnlw 1 4 authors author NNS cord-339015-qn8wbnlw 1 5 : : : cord-339015-qn8wbnlw 1 6 Kayingo Kayingo NNP cord-339015-qn8wbnlw 1 7 , , , cord-339015-qn8wbnlw 1 8 Gerald Gerald NNP cord-339015-qn8wbnlw 1 9 title title NN cord-339015-qn8wbnlw 1 10 : : : cord-339015-qn8wbnlw 1 11 Bacteria Bacteria NNS cord-339015-qn8wbnlw 1 12 and and CC cord-339015-qn8wbnlw 1 13 Viruses virus NNS cord-339015-qn8wbnlw 1 14 : : : cord-339015-qn8wbnlw 2 1 The the DT cord-339015-qn8wbnlw 2 2 Bogeymen bogeyman NNS cord-339015-qn8wbnlw 2 3 in in IN cord-339015-qn8wbnlw 2 4 the the DT cord-339015-qn8wbnlw 2 5 Intensive Intensive NNP cord-339015-qn8wbnlw 2 6 Care Care NNP cord-339015-qn8wbnlw 2 7 Unit Unit NNP cord-339015-qn8wbnlw 2 8 date date NN cord-339015-qn8wbnlw 2 9 : : : cord-339015-qn8wbnlw 2 10 2019 2019 CD cord-339015-qn8wbnlw 2 11 - - HYPH cord-339015-qn8wbnlw 2 12 03 03 CD cord-339015-qn8wbnlw 2 13 - - HYPH cord-339015-qn8wbnlw 2 14 06 06 CD cord-339015-qn8wbnlw 2 15 journal journal NN cord-339015-qn8wbnlw 2 16 : : : cord-339015-qn8wbnlw 3 1 Physician Physician NNP cord-339015-qn8wbnlw 3 2 Assist Assist NNP cord-339015-qn8wbnlw 3 3 Clin Clin NNP cord-339015-qn8wbnlw 3 4 DOI DOI NNP cord-339015-qn8wbnlw 3 5 : : : cord-339015-qn8wbnlw 3 6 10.1016 10.1016 CD cord-339015-qn8wbnlw 4 1 /j.cpha.2018.11.003 /j.cpha.2018.11.003 NFP cord-339015-qn8wbnlw 4 2 sha sha NNP cord-339015-qn8wbnlw 4 3 : : : cord-339015-qn8wbnlw 4 4 f816588cb0c1ccdd69608881dd497578b4600b93 f816588cb0c1ccdd69608881dd497578b4600b93 NNP cord-339015-qn8wbnlw 4 5 doc_id doc_id CD cord-339015-qn8wbnlw 4 6 : : : cord-339015-qn8wbnlw 4 7 339015 339015 CD cord-339015-qn8wbnlw 4 8 cord_uid cord_uid NNS cord-339015-qn8wbnlw 4 9 : : : cord-339015-qn8wbnlw 4 10 qn8wbnlw qn8wbnlw . cord-339015-qn8wbnlw 5 1 This this DT cord-339015-qn8wbnlw 5 2 article article NN cord-339015-qn8wbnlw 5 3 covers cover VBZ cord-339015-qn8wbnlw 5 4 the the DT cord-339015-qn8wbnlw 5 5 frequently frequently RB cord-339015-qn8wbnlw 5 6 encountered encounter VBN cord-339015-qn8wbnlw 5 7 bacteria bacteria NNS cord-339015-qn8wbnlw 5 8 and and CC cord-339015-qn8wbnlw 5 9 viruses virus NNS cord-339015-qn8wbnlw 5 10 in in IN cord-339015-qn8wbnlw 5 11 the the DT cord-339015-qn8wbnlw 5 12 ICU ICU NNP cord-339015-qn8wbnlw 5 13 . . . cord-339015-qn8wbnlw 6 1 It -PRON- PRP cord-339015-qn8wbnlw 6 2 focuses focus VBZ cord-339015-qn8wbnlw 6 3 on on IN cord-339015-qn8wbnlw 6 4 recognition recognition NN cord-339015-qn8wbnlw 6 5 , , , cord-339015-qn8wbnlw 6 6 management management NN cord-339015-qn8wbnlw 6 7 , , , cord-339015-qn8wbnlw 6 8 and and CC cord-339015-qn8wbnlw 6 9 prevention prevention NN cord-339015-qn8wbnlw 6 10 . . . cord-339015-qn8wbnlw 7 1 Emerging emerge VBG cord-339015-qn8wbnlw 7 2 and and CC cord-339015-qn8wbnlw 7 3 difficult difficult JJ cord-339015-qn8wbnlw 7 4 - - HYPH cord-339015-qn8wbnlw 7 5 to to TO cord-339015-qn8wbnlw 7 6 - - HYPH cord-339015-qn8wbnlw 7 7 treat treat NN cord-339015-qn8wbnlw 7 8 organisms organism NNS cord-339015-qn8wbnlw 7 9 are be VBP cord-339015-qn8wbnlw 7 10 covered cover VBN cord-339015-qn8wbnlw 7 11 in in IN cord-339015-qn8wbnlw 7 12 detail detail NN cord-339015-qn8wbnlw 7 13 . . . cord-339015-qn8wbnlw 8 1 VAP VAP NNP cord-339015-qn8wbnlw 8 2 is be VBZ cord-339015-qn8wbnlw 8 3 a a DT cord-339015-qn8wbnlw 8 4 nosocomial nosocomial JJ cord-339015-qn8wbnlw 8 5 infection infection NN cord-339015-qn8wbnlw 8 6 of of IN cord-339015-qn8wbnlw 8 7 the the DT cord-339015-qn8wbnlw 8 8 lung lung NN cord-339015-qn8wbnlw 8 9 tissue tissue NN cord-339015-qn8wbnlw 8 10 that that WDT cord-339015-qn8wbnlw 8 11 develops develop VBZ cord-339015-qn8wbnlw 8 12 more more JJR cord-339015-qn8wbnlw 8 13 than than IN cord-339015-qn8wbnlw 8 14 48 48 CD cord-339015-qn8wbnlw 8 15 hours hour NNS cord-339015-qn8wbnlw 8 16 after after IN cord-339015-qn8wbnlw 8 17 intubation intubation NN cord-339015-qn8wbnlw 8 18 in in IN cord-339015-qn8wbnlw 8 19 mechanically mechanically RB cord-339015-qn8wbnlw 8 20 ventilated ventilate VBN cord-339015-qn8wbnlw 8 21 patients patient NNS cord-339015-qn8wbnlw 8 22 . . . cord-339015-qn8wbnlw 9 1 Critically critically RB cord-339015-qn8wbnlw 9 2 ill ill RB cord-339015-qn8wbnlw 9 3 ventilated ventilate VBN cord-339015-qn8wbnlw 9 4 patients patient NNS cord-339015-qn8wbnlw 9 5 are be VBP cord-339015-qn8wbnlw 9 6 very very RB cord-339015-qn8wbnlw 9 7 susceptible susceptible JJ cord-339015-qn8wbnlw 9 8 to to IN cord-339015-qn8wbnlw 9 9 pneumonia pneumonia NN cord-339015-qn8wbnlw 9 10 due due IN cord-339015-qn8wbnlw 9 11 to to IN cord-339015-qn8wbnlw 9 12 an an DT cord-339015-qn8wbnlw 9 13 impaired impaired JJ cord-339015-qn8wbnlw 9 14 immune immune JJ cord-339015-qn8wbnlw 9 15 system system NN cord-339015-qn8wbnlw 9 16 and and CC cord-339015-qn8wbnlw 9 17 a a DT cord-339015-qn8wbnlw 9 18 breakdown breakdown NN cord-339015-qn8wbnlw 9 19 of of IN cord-339015-qn8wbnlw 9 20 anatomic anatomic JJ cord-339015-qn8wbnlw 9 21 barriers barrier NNS cord-339015-qn8wbnlw 9 22 that that WDT cord-339015-qn8wbnlw 9 23 protect protect VBP cord-339015-qn8wbnlw 9 24 the the DT cord-339015-qn8wbnlw 9 25 lower low JJR cord-339015-qn8wbnlw 9 26 respiratory respiratory JJ cord-339015-qn8wbnlw 9 27 tract tract NN cord-339015-qn8wbnlw 9 28 . . . cord-339015-qn8wbnlw 10 1 The the DT cord-339015-qn8wbnlw 10 2 risk risk NN cord-339015-qn8wbnlw 10 3 of of IN cord-339015-qn8wbnlw 10 4 acquiring acquire VBG cord-339015-qn8wbnlw 10 5 VAP VAP NNP cord-339015-qn8wbnlw 10 6 increases increase VBZ cord-339015-qn8wbnlw 10 7 with with IN cord-339015-qn8wbnlw 10 8 older old JJR cord-339015-qn8wbnlw 10 9 age age NN cord-339015-qn8wbnlw 10 10 ( ( -LRB- cord-339015-qn8wbnlw 10 11 > > NFP cord-339015-qn8wbnlw 10 12 60 60 CD cord-339015-qn8wbnlw 10 13 years year NNS cord-339015-qn8wbnlw 10 14 ) ) -RRB- cord-339015-qn8wbnlw 10 15 , , , cord-339015-qn8wbnlw 10 16 a a DT cord-339015-qn8wbnlw 10 17 history history NN cord-339015-qn8wbnlw 10 18 of of IN cord-339015-qn8wbnlw 10 19 smoking smoking NN cord-339015-qn8wbnlw 10 20 , , , cord-339015-qn8wbnlw 10 21 alcoholism alcoholism NN cord-339015-qn8wbnlw 10 22 , , , cord-339015-qn8wbnlw 10 23 prolonged prolong VBN cord-339015-qn8wbnlw 10 24 stay stay NN cord-339015-qn8wbnlw 10 25 in in IN cord-339015-qn8wbnlw 10 26 the the DT cord-339015-qn8wbnlw 10 27 ICU ICU NNP cord-339015-qn8wbnlw 10 28 , , , cord-339015-qn8wbnlw 10 29 and and CC cord-339015-qn8wbnlw 10 30 chronic chronic JJ cord-339015-qn8wbnlw 10 31 comorbid comorbid NN cord-339015-qn8wbnlw 10 32 conditions condition NNS cord-339015-qn8wbnlw 10 33 , , , cord-339015-qn8wbnlw 10 34 such such JJ cord-339015-qn8wbnlw 10 35 as as IN cord-339015-qn8wbnlw 10 36 diabetes diabetes NN cord-339015-qn8wbnlw 10 37 and and CC cord-339015-qn8wbnlw 10 38 chronic chronic JJ cord-339015-qn8wbnlw 10 39 obstructive obstructive JJ cord-339015-qn8wbnlw 10 40 pulmonary pulmonary JJ cord-339015-qn8wbnlw 10 41 disease disease NN cord-339015-qn8wbnlw 10 42 . . . cord-339015-qn8wbnlw 11 1 There there EX cord-339015-qn8wbnlw 11 2 are be VBP cord-339015-qn8wbnlw 11 3 many many JJ cord-339015-qn8wbnlw 11 4 etiologic etiologic JJ cord-339015-qn8wbnlw 11 5 agents agent NNS cord-339015-qn8wbnlw 11 6 for for IN cord-339015-qn8wbnlw 11 7 VAP VAP NNP cord-339015-qn8wbnlw 11 8 . . . cord-339015-qn8wbnlw 12 1 Early early JJ cord-339015-qn8wbnlw 12 2 - - HYPH cord-339015-qn8wbnlw 12 3 onset onset NN cord-339015-qn8wbnlw 12 4 VAP VAP NNP cord-339015-qn8wbnlw 12 5 ( ( -LRB- cord-339015-qn8wbnlw 12 6 less less JJR cord-339015-qn8wbnlw 12 7 than than IN cord-339015-qn8wbnlw 12 8 7 7 CD cord-339015-qn8wbnlw 12 9 days day NNS cord-339015-qn8wbnlw 12 10 of of IN cord-339015-qn8wbnlw 12 11 mechanical mechanical JJ cord-339015-qn8wbnlw 12 12 ventilation ventilation NN cord-339015-qn8wbnlw 12 13 ) ) -RRB- cord-339015-qn8wbnlw 12 14 is be VBZ cord-339015-qn8wbnlw 12 15 usually usually RB cord-339015-qn8wbnlw 12 16 caused cause VBN cord-339015-qn8wbnlw 12 17 by by IN cord-339015-qn8wbnlw 12 18 Haemophilus Haemophilus NNP cord-339015-qn8wbnlw 12 19 influenzae influenzae NN cord-339015-qn8wbnlw 12 20 , , , cord-339015-qn8wbnlw 12 21 Streptococcus streptococcus NN cord-339015-qn8wbnlw 12 22 pneumoniae pneumoniae NN cord-339015-qn8wbnlw 12 23 , , , cord-339015-qn8wbnlw 12 24 or or CC cord-339015-qn8wbnlw 12 25 Staphylococcus Staphylococcus NNP cord-339015-qn8wbnlw 12 26 aureus aureus NN cord-339015-qn8wbnlw 12 27 ( ( -LRB- cord-339015-qn8wbnlw 12 28 methicillin methicillin NN cord-339015-qn8wbnlw 12 29 - - HYPH cord-339015-qn8wbnlw 12 30 sensitive sensitive JJ cord-339015-qn8wbnlw 12 31 ) ) -RRB- cord-339015-qn8wbnlw 12 32 . . . cord-339015-qn8wbnlw 13 1 Late late JJ cord-339015-qn8wbnlw 13 2 - - HYPH cord-339015-qn8wbnlw 13 3 onset onset NN cord-339015-qn8wbnlw 13 4 VAP VAP NNP cord-339015-qn8wbnlw 13 5 ( ( -LRB- cord-339015-qn8wbnlw 13 6 > > NFP cord-339015-qn8wbnlw 13 7 7 7 CD cord-339015-qn8wbnlw 13 8 days day NNS cord-339015-qn8wbnlw 13 9 after after IN cord-339015-qn8wbnlw 13 10 mechanical mechanical JJ cord-339015-qn8wbnlw 13 11 ventilation ventilation NN cord-339015-qn8wbnlw 13 12 ) ) -RRB- cord-339015-qn8wbnlw 13 13 is be VBZ cord-339015-qn8wbnlw 13 14 usually usually RB cord-339015-qn8wbnlw 13 15 caused cause VBN cord-339015-qn8wbnlw 13 16 by by IN cord-339015-qn8wbnlw 13 17 Pseudomonas Pseudomonas NNP cord-339015-qn8wbnlw 13 18 aeruginosa aeruginosa NN cord-339015-qn8wbnlw 13 19 , , , cord-339015-qn8wbnlw 13 20 Acinetobacter Acinetobacter NNP cord-339015-qn8wbnlw 13 21 species specie NNS cord-339015-qn8wbnlw 13 22 , , , cord-339015-qn8wbnlw 13 23 methicillin methicillin NN cord-339015-qn8wbnlw 13 24 - - HYPH cord-339015-qn8wbnlw 13 25 resistant resistant JJ cord-339015-qn8wbnlw 13 26 S S NNP cord-339015-qn8wbnlw 13 27 aureus aureus NN cord-339015-qn8wbnlw 13 28 ( ( -LRB- cord-339015-qn8wbnlw 13 29 MRSA MRSA NNP cord-339015-qn8wbnlw 13 30 ) ) -RRB- cord-339015-qn8wbnlw 13 31 , , , cord-339015-qn8wbnlw 13 32 and and CC cord-339015-qn8wbnlw 13 33 multidrug multidrug NN cord-339015-qn8wbnlw 13 34 - - HYPH cord-339015-qn8wbnlw 13 35 resistant resistant JJ cord-339015-qn8wbnlw 13 36 gram gram NN cord-339015-qn8wbnlw 13 37 - - HYPH cord-339015-qn8wbnlw 13 38 negative negative JJ cord-339015-qn8wbnlw 13 39 bacilli bacilli NN cord-339015-qn8wbnlw 13 40 . . . cord-339015-qn8wbnlw 14 1 2 2 LS cord-339015-qn8wbnlw 14 2 Clinical clinical JJ cord-339015-qn8wbnlw 14 3 signs sign NNS cord-339015-qn8wbnlw 14 4 and and CC cord-339015-qn8wbnlw 14 5 symptoms symptom NNS cord-339015-qn8wbnlw 14 6 for for IN cord-339015-qn8wbnlw 14 7 VAP VAP NNP cord-339015-qn8wbnlw 14 8 include include VBP cord-339015-qn8wbnlw 14 9 presence presence NN cord-339015-qn8wbnlw 14 10 of of IN cord-339015-qn8wbnlw 14 11 a a DT cord-339015-qn8wbnlw 14 12 new new JJ cord-339015-qn8wbnlw 14 13 onset onset NN cord-339015-qn8wbnlw 14 14 of of IN cord-339015-qn8wbnlw 14 15 fever fever NN cord-339015-qn8wbnlw 14 16 , , , cord-339015-qn8wbnlw 14 17 increased increase VBN cord-339015-qn8wbnlw 14 18 productive productive JJ cord-339015-qn8wbnlw 14 19 cough cough NN cord-339015-qn8wbnlw 14 20 with with IN cord-339015-qn8wbnlw 14 21 sputum sputum NN cord-339015-qn8wbnlw 14 22 , , , cord-339015-qn8wbnlw 14 23 leukocytosis leukocytosis NN cord-339015-qn8wbnlw 14 24 , , , cord-339015-qn8wbnlw 14 25 worsening worsen VBG cord-339015-qn8wbnlw 14 26 gas gas NN cord-339015-qn8wbnlw 14 27 exchange exchange NN cord-339015-qn8wbnlw 14 28 , , , cord-339015-qn8wbnlw 14 29 and and CC cord-339015-qn8wbnlw 14 30 new new JJ cord-339015-qn8wbnlw 14 31 pulmonary pulmonary NN cord-339015-qn8wbnlw 14 32 infiltrates infiltrate VBZ cord-339015-qn8wbnlw 14 33 on on IN cord-339015-qn8wbnlw 14 34 a a DT cord-339015-qn8wbnlw 14 35 chest chest NN cord-339015-qn8wbnlw 14 36 radiograph radiograph NN cord-339015-qn8wbnlw 14 37 . . . cord-339015-qn8wbnlw 15 1 Invasive invasive JJ cord-339015-qn8wbnlw 15 2 diagnosis diagnosis NN cord-339015-qn8wbnlw 15 3 with with IN cord-339015-qn8wbnlw 15 4 bronchoalveolar bronchoalveolar NNP cord-339015-qn8wbnlw 15 5 lavage lavage NN cord-339015-qn8wbnlw 15 6 is be VBZ cord-339015-qn8wbnlw 15 7 generally generally RB cord-339015-qn8wbnlw 15 8 recommended recommend VBN cord-339015-qn8wbnlw 15 9 to to TO cord-339015-qn8wbnlw 15 10 make make VB cord-339015-qn8wbnlw 15 11 a a DT cord-339015-qn8wbnlw 15 12 definitive definitive JJ cord-339015-qn8wbnlw 15 13 diagnosis diagnosis NN cord-339015-qn8wbnlw 15 14 . . . cord-339015-qn8wbnlw 16 1 For for IN cord-339015-qn8wbnlw 16 2 the the DT cord-339015-qn8wbnlw 16 3 management management NN cord-339015-qn8wbnlw 16 4 of of IN cord-339015-qn8wbnlw 16 5 VAP VAP NNP cord-339015-qn8wbnlw 16 6 , , , cord-339015-qn8wbnlw 16 7 advance advance NN cord-339015-qn8wbnlw 16 8 practice practice NN cord-339015-qn8wbnlw 16 9 providers provider NNS cord-339015-qn8wbnlw 16 10 ( ( -LRB- cord-339015-qn8wbnlw 16 11 APPs app NNS cord-339015-qn8wbnlw 16 12 ) ) -RRB- cord-339015-qn8wbnlw 16 13 should should MD cord-339015-qn8wbnlw 16 14 direct direct VB cord-339015-qn8wbnlw 16 15 initial initial JJ cord-339015-qn8wbnlw 16 16 antibiotic antibiotic JJ cord-339015-qn8wbnlw 16 17 therapy therapy NN cord-339015-qn8wbnlw 16 18 against against IN cord-339015-qn8wbnlw 16 19 organisms organism NNS cord-339015-qn8wbnlw 16 20 that that WDT cord-339015-qn8wbnlw 16 21 are be VBP cord-339015-qn8wbnlw 16 22 known know VBN cord-339015-qn8wbnlw 16 23 to to TO cord-339015-qn8wbnlw 16 24 frequently frequently RB cord-339015-qn8wbnlw 16 25 cause cause VB cord-339015-qn8wbnlw 16 26 pneumonia pneumonia NN cord-339015-qn8wbnlw 16 27 in in IN cord-339015-qn8wbnlw 16 28 the the DT cord-339015-qn8wbnlw 16 29 ICU ICU NNP cord-339015-qn8wbnlw 16 30 . . . cord-339015-qn8wbnlw 17 1 Obtain obtain VB cord-339015-qn8wbnlw 17 2 sputum sputum NN cord-339015-qn8wbnlw 17 3 and and CC cord-339015-qn8wbnlw 17 4 blood blood NN cord-339015-qn8wbnlw 17 5 cultures culture NNS cord-339015-qn8wbnlw 17 6 and and CC cord-339015-qn8wbnlw 17 7 initiate initiate VB cord-339015-qn8wbnlw 17 8 appropriate appropriate JJ cord-339015-qn8wbnlw 17 9 empiric empiric JJ cord-339015-qn8wbnlw 17 10 broadspectrum broadspectrum NN cord-339015-qn8wbnlw 17 11 without without IN cord-339015-qn8wbnlw 17 12 delay delay NN cord-339015-qn8wbnlw 17 13 . . . cord-339015-qn8wbnlw 18 1 Therapeutic therapeutic JJ cord-339015-qn8wbnlw 18 2 choices choice NNS cord-339015-qn8wbnlw 18 3 include include VBP cord-339015-qn8wbnlw 18 4 a a DT cord-339015-qn8wbnlw 18 5 combination combination NN cord-339015-qn8wbnlw 18 6 of of IN cord-339015-qn8wbnlw 18 7 ceftazidime ceftazidime NN cord-339015-qn8wbnlw 18 8 and and CC cord-339015-qn8wbnlw 18 9 ciprofloxacin ciprofloxacin NN cord-339015-qn8wbnlw 18 10 , , , cord-339015-qn8wbnlw 18 11 when when WRB cord-339015-qn8wbnlw 18 12 covering cover VBG cord-339015-qn8wbnlw 18 13 P. p. NN cord-339015-qn8wbnlw 18 14 aeruginosa aeruginosa NN cord-339015-qn8wbnlw 18 15 , , , cord-339015-qn8wbnlw 18 16 and and CC cord-339015-qn8wbnlw 18 17 carbapenems carbapenem NNS cord-339015-qn8wbnlw 18 18 , , , cord-339015-qn8wbnlw 18 19 such such JJ cord-339015-qn8wbnlw 18 20 as as IN cord-339015-qn8wbnlw 18 21 imipenem imipenem NNP cord-339015-qn8wbnlw 18 22 - - HYPH cord-339015-qn8wbnlw 18 23 cilastatin cilastatin NNP cord-339015-qn8wbnlw 18 24 , , , cord-339015-qn8wbnlw 18 25 when when WRB cord-339015-qn8wbnlw 18 26 covering cover VBG cord-339015-qn8wbnlw 18 27 extended extend VBN cord-339015-qn8wbnlw 18 28 - - HYPH cord-339015-qn8wbnlw 18 29 spectrum spectrum NN cord-339015-qn8wbnlw 18 30 b b NN cord-339015-qn8wbnlw 18 31 - - : cord-339015-qn8wbnlw 18 32 lactamase lactamase NN cord-339015-qn8wbnlw 18 33 ( ( -LRB- cord-339015-qn8wbnlw 18 34 ESBL)-producing esbl)-produce VBG cord-339015-qn8wbnlw 18 35 pathogens pathogen NNS cord-339015-qn8wbnlw 18 36 , , , cord-339015-qn8wbnlw 18 37 such such JJ cord-339015-qn8wbnlw 18 38 as as IN cord-339015-qn8wbnlw 18 39 Klebsiella Klebsiella NNP cord-339015-qn8wbnlw 18 40 species specie NNS cord-339015-qn8wbnlw 18 41 . . . cord-339015-qn8wbnlw 19 1 For for IN cord-339015-qn8wbnlw 19 2 ICUs ICUs NNP cord-339015-qn8wbnlw 19 3 with with IN cord-339015-qn8wbnlw 19 4 a a DT cord-339015-qn8wbnlw 19 5 high high JJ cord-339015-qn8wbnlw 19 6 prevalence prevalence NN cord-339015-qn8wbnlw 19 7 of of IN cord-339015-qn8wbnlw 19 8 MRSA MRSA NNP cord-339015-qn8wbnlw 19 9 , , , cord-339015-qn8wbnlw 19 10 vancomycin vancomycin NN cord-339015-qn8wbnlw 19 11 should should MD cord-339015-qn8wbnlw 19 12 be be VB cord-339015-qn8wbnlw 19 13 used use VBN cord-339015-qn8wbnlw 19 14 . . . cord-339015-qn8wbnlw 20 1 Management management NN cord-339015-qn8wbnlw 20 2 of of IN cord-339015-qn8wbnlw 20 3 infections infection NNS cord-339015-qn8wbnlw 20 4 in in IN cord-339015-qn8wbnlw 20 5 the the DT cord-339015-qn8wbnlw 20 6 ICU ICU NNP cord-339015-qn8wbnlw 20 7 can can MD cord-339015-qn8wbnlw 20 8 be be VB cord-339015-qn8wbnlw 20 9 challenging challenge VBG cord-339015-qn8wbnlw 20 10 due due IN cord-339015-qn8wbnlw 20 11 to to IN cord-339015-qn8wbnlw 20 12 the the DT cord-339015-qn8wbnlw 20 13 rise rise NN cord-339015-qn8wbnlw 20 14 of of IN cord-339015-qn8wbnlw 20 15 multidrugresistant multidrugresistant NN cord-339015-qn8wbnlw 20 16 organisms organism NNS cord-339015-qn8wbnlw 20 17 ( ( -LRB- cord-339015-qn8wbnlw 20 18 Box Box NNP cord-339015-qn8wbnlw 20 19 1 1 CD cord-339015-qn8wbnlw 20 20 ) ) -RRB- cord-339015-qn8wbnlw 20 21 . . . cord-339015-qn8wbnlw 21 1 Among among IN cord-339015-qn8wbnlw 21 2 the the DT cord-339015-qn8wbnlw 21 3 most most RBS cord-339015-qn8wbnlw 21 4 problematic problematic JJ cord-339015-qn8wbnlw 21 5 pathogens pathogen NNS cord-339015-qn8wbnlw 21 6 are be VBP cord-339015-qn8wbnlw 21 7 the the DT cord-339015-qn8wbnlw 21 8 following follow VBG cord-339015-qn8wbnlw 21 9 : : : cord-339015-qn8wbnlw 21 10 ESBL ESBL NNP cord-339015-qn8wbnlw 21 11 - - HYPH cord-339015-qn8wbnlw 21 12 producing produce VBG cord-339015-qn8wbnlw 21 13 Enterobacteriaceae Enterobacteriaceae NNP cord-339015-qn8wbnlw 21 14 , , , cord-339015-qn8wbnlw 21 15 such such JJ cord-339015-qn8wbnlw 21 16 as as IN cord-339015-qn8wbnlw 21 17 Klebsiella Klebsiella NNP cord-339015-qn8wbnlw 21 18 species specie NNS cord-339015-qn8wbnlw 21 19 and and CC cord-339015-qn8wbnlw 21 20 Escherichia escherichia NN cord-339015-qn8wbnlw 21 21 coli coli NNS cord-339015-qn8wbnlw 21 22 , , , cord-339015-qn8wbnlw 21 23 which which WDT cord-339015-qn8wbnlw 21 24 may may MD cord-339015-qn8wbnlw 21 25 be be VB cord-339015-qn8wbnlw 21 26 resistant resistant JJ cord-339015-qn8wbnlw 21 27 to to IN cord-339015-qn8wbnlw 21 28 penicillins penicillin NNS cord-339015-qn8wbnlw 21 29 and and CC cord-339015-qn8wbnlw 21 30 cephalosporins cephalosporin NNS cord-339015-qn8wbnlw 22 1 For for IN cord-339015-qn8wbnlw 22 2 most most JJS cord-339015-qn8wbnlw 22 3 ESBL ESBL NNP cord-339015-qn8wbnlw 22 4 - - HYPH cord-339015-qn8wbnlw 22 5 producing produce VBG cord-339015-qn8wbnlw 22 6 organisms organism NNS cord-339015-qn8wbnlw 22 7 , , , cord-339015-qn8wbnlw 22 8 carbapenems carbapenem NNS cord-339015-qn8wbnlw 22 9 , , , cord-339015-qn8wbnlw 22 10 such such JJ cord-339015-qn8wbnlw 22 11 as as IN cord-339015-qn8wbnlw 22 12 imipenem imipenem NNP cord-339015-qn8wbnlw 22 13 and and CC cord-339015-qn8wbnlw 22 14 meropenem meropenem NNP cord-339015-qn8wbnlw 22 15 , , , cord-339015-qn8wbnlw 22 16 are be VBP cord-339015-qn8wbnlw 22 17 the the DT cord-339015-qn8wbnlw 22 18 drugs drug NNS cord-339015-qn8wbnlw 22 19 of of IN cord-339015-qn8wbnlw 22 20 choice choice NN cord-339015-qn8wbnlw 22 21 . . . cord-339015-qn8wbnlw 23 1 P. P. NNP cord-339015-qn8wbnlw 23 2 aeruginosa aeruginosa NN cord-339015-qn8wbnlw 23 3 is be VBZ cord-339015-qn8wbnlw 23 4 one one CD cord-339015-qn8wbnlw 23 5 of of IN cord-339015-qn8wbnlw 23 6 the the DT cord-339015-qn8wbnlw 23 7 leading lead VBG cord-339015-qn8wbnlw 23 8 causes cause NNS cord-339015-qn8wbnlw 23 9 of of IN cord-339015-qn8wbnlw 23 10 morbidity morbidity NN cord-339015-qn8wbnlw 23 11 in in IN cord-339015-qn8wbnlw 23 12 ICU ICU NNP cord-339015-qn8wbnlw 23 13 patients patient NNS cord-339015-qn8wbnlw 23 14 , , , cord-339015-qn8wbnlw 23 15 especially especially RB cord-339015-qn8wbnlw 23 16 those those DT cord-339015-qn8wbnlw 23 17 with with IN cord-339015-qn8wbnlw 23 18 VAP VAP NNP cord-339015-qn8wbnlw 23 19 . . . cord-339015-qn8wbnlw 24 1 It -PRON- PRP cord-339015-qn8wbnlw 24 2 is be VBZ cord-339015-qn8wbnlw 24 3 also also RB cord-339015-qn8wbnlw 24 4 a a DT cord-339015-qn8wbnlw 24 5 common common JJ cord-339015-qn8wbnlw 24 6 cause cause NN cord-339015-qn8wbnlw 24 7 of of IN cord-339015-qn8wbnlw 24 8 ICU ICU NNP cord-339015-qn8wbnlw 24 9 infections infection NNS cord-339015-qn8wbnlw 24 10 associated associate VBN cord-339015-qn8wbnlw 24 11 with with IN cord-339015-qn8wbnlw 24 12 devices device NNS cord-339015-qn8wbnlw 24 13 and and CC cord-339015-qn8wbnlw 24 14 catheters catheter NNS cord-339015-qn8wbnlw 24 15 , , , cord-339015-qn8wbnlw 24 16 infections infection NNS cord-339015-qn8wbnlw 24 17 in in IN cord-339015-qn8wbnlw 24 18 the the DT cord-339015-qn8wbnlw 24 19 urinary urinary JJ cord-339015-qn8wbnlw 24 20 tract tract NN cord-339015-qn8wbnlw 24 21 , , , cord-339015-qn8wbnlw 24 22 and and CC cord-339015-qn8wbnlw 24 23 surgical surgical JJ cord-339015-qn8wbnlw 24 24 site site NN cord-339015-qn8wbnlw 24 25 infections infection NNS cord-339015-qn8wbnlw 24 26 . . . cord-339015-qn8wbnlw 25 1 3 3 LS cord-339015-qn8wbnlw 25 2 Increasing increase VBG cord-339015-qn8wbnlw 25 3 rates rate NNS cord-339015-qn8wbnlw 25 4 of of IN cord-339015-qn8wbnlw 25 5 multidrug multidrug NN cord-339015-qn8wbnlw 25 6 resistance resistance NN cord-339015-qn8wbnlw 25 7 have have VBP cord-339015-qn8wbnlw 25 8 been be VBN cord-339015-qn8wbnlw 25 9 noted note VBN cord-339015-qn8wbnlw 25 10 , , , cord-339015-qn8wbnlw 25 11 especially especially RB cord-339015-qn8wbnlw 25 12 in in IN cord-339015-qn8wbnlw 25 13 immunocompromised immunocompromised JJ cord-339015-qn8wbnlw 25 14 hosts host NNS cord-339015-qn8wbnlw 25 15 ( ( -LRB- cord-339015-qn8wbnlw 25 16 Box Box NNP cord-339015-qn8wbnlw 25 17 2 2 CD cord-339015-qn8wbnlw 25 18 ) ) -RRB- cord-339015-qn8wbnlw 25 19 , , , cord-339015-qn8wbnlw 25 20 those those DT cord-339015-qn8wbnlw 25 21 patients patient NNS cord-339015-qn8wbnlw 25 22 with with IN cord-339015-qn8wbnlw 25 23 prolonged prolonged JJ cord-339015-qn8wbnlw 25 24 hospital hospital NN cord-339015-qn8wbnlw 25 25 stays stay NNS cord-339015-qn8wbnlw 25 26 , , , cord-339015-qn8wbnlw 25 27 those those DT cord-339015-qn8wbnlw 25 28 patients patient NNS cord-339015-qn8wbnlw 25 29 with with IN cord-339015-qn8wbnlw 25 30 invasive invasive JJ cord-339015-qn8wbnlw 25 31 devices device NNS cord-339015-qn8wbnlw 25 32 or or CC cord-339015-qn8wbnlw 25 33 mechanical mechanical JJ cord-339015-qn8wbnlw 25 34 ventilation ventilation NN cord-339015-qn8wbnlw 25 35 , , , cord-339015-qn8wbnlw 25 36 and and CC cord-339015-qn8wbnlw 25 37 those those DT cord-339015-qn8wbnlw 25 38 patients patient NNS cord-339015-qn8wbnlw 25 39 with with IN cord-339015-qn8wbnlw 25 40 prior prior JJ cord-339015-qn8wbnlw 25 41 prolonged prolong VBN cord-339015-qn8wbnlw 25 42 antibiotic antibiotic JJ cord-339015-qn8wbnlw 25 43 use use NN cord-339015-qn8wbnlw 25 44 . . . cord-339015-qn8wbnlw 26 1 Risk risk NN cord-339015-qn8wbnlw 26 2 factors factor NNS cord-339015-qn8wbnlw 26 3 for for IN cord-339015-qn8wbnlw 26 4 acquiring acquire VBG cord-339015-qn8wbnlw 26 5 pseudomonal pseudomonal JJ cord-339015-qn8wbnlw 26 6 infections infection NNS cord-339015-qn8wbnlw 26 7 are be VBP cord-339015-qn8wbnlw 26 8 age age NN cord-339015-qn8wbnlw 26 9 , , , cord-339015-qn8wbnlw 26 10 comorbidities comorbiditie NNS cord-339015-qn8wbnlw 26 11 at at IN cord-339015-qn8wbnlw 26 12 ICU ICU NNP cord-339015-qn8wbnlw 26 13 admission admission NN cord-339015-qn8wbnlw 26 14 ( ( -LRB- cord-339015-qn8wbnlw 26 15 such such JJ cord-339015-qn8wbnlw 26 16 as as IN cord-339015-qn8wbnlw 26 17 anemia anemia NN cord-339015-qn8wbnlw 26 18 and and CC cord-339015-qn8wbnlw 26 19 burns burn NNS cord-339015-qn8wbnlw 26 20 ) ) -RRB- cord-339015-qn8wbnlw 26 21 , , , cord-339015-qn8wbnlw 26 22 and/or and/or CC cord-339015-qn8wbnlw 26 23 invasive invasive JJ cord-339015-qn8wbnlw 26 24 devices device NNS cord-339015-qn8wbnlw 26 25 . . . cord-339015-qn8wbnlw 27 1 For for IN cord-339015-qn8wbnlw 27 2 the the DT cord-339015-qn8wbnlw 27 3 treatment treatment NN cord-339015-qn8wbnlw 27 4 of of IN cord-339015-qn8wbnlw 27 5 problematic problematic JJ cord-339015-qn8wbnlw 27 6 multidrug multidrug NN cord-339015-qn8wbnlw 27 7 - - HYPH cord-339015-qn8wbnlw 27 8 resistant resistant JJ cord-339015-qn8wbnlw 27 9 pseudomonas pseudomonas NN cord-339015-qn8wbnlw 27 10 , , , cord-339015-qn8wbnlw 27 11 current current JJ cord-339015-qn8wbnlw 27 12 treatment treatment NN cord-339015-qn8wbnlw 27 13 options option NNS cord-339015-qn8wbnlw 27 14 include include VBP cord-339015-qn8wbnlw 27 15 the the DT cord-339015-qn8wbnlw 27 16 following follow VBG cord-339015-qn8wbnlw 27 17 combinations combination NNS cord-339015-qn8wbnlw 27 18 : : : cord-339015-qn8wbnlw 28 1 Ceftolozane Ceftolozane NNP cord-339015-qn8wbnlw 28 2 / / SYM cord-339015-qn8wbnlw 28 3 tazobactam tazobactam NNS cord-339015-qn8wbnlw 28 4 Ceftazidime Ceftazidime NNP cord-339015-qn8wbnlw 28 5 / / SYM cord-339015-qn8wbnlw 28 6 avibactam avibactam NNP cord-339015-qn8wbnlw 28 7 Piperacillin Piperacillin NNP cord-339015-qn8wbnlw 28 8 / / SYM cord-339015-qn8wbnlw 28 9 tazobactam tazobactam NNP cord-339015-qn8wbnlw 28 10 Cefepime Cefepime NNP cord-339015-qn8wbnlw 28 11 , , , cord-339015-qn8wbnlw 28 12 ceftazidime ceftazidime NN cord-339015-qn8wbnlw 28 13 , , , cord-339015-qn8wbnlw 28 14 or or CC cord-339015-qn8wbnlw 28 15 a a DT cord-339015-qn8wbnlw 28 16 carbapenem carbapenem NN cord-339015-qn8wbnlw 28 17 plus plus CC cord-339015-qn8wbnlw 28 18 an an DT cord-339015-qn8wbnlw 28 19 additional additional JJ cord-339015-qn8wbnlw 28 20 agent(s agent(s NNP cord-339015-qn8wbnlw 28 21 ) ) -RRB- cord-339015-qn8wbnlw 28 22 , , , cord-339015-qn8wbnlw 28 23 such such JJ cord-339015-qn8wbnlw 28 24 as as IN cord-339015-qn8wbnlw 28 25 colistin colistin NNP cord-339015-qn8wbnlw 28 26 , , , cord-339015-qn8wbnlw 28 27 fosfomycin fosfomycin NNP cord-339015-qn8wbnlw 28 28 , , , cord-339015-qn8wbnlw 28 29 aminoglycoside aminoglycoside NNP cord-339015-qn8wbnlw 28 30 , , , cord-339015-qn8wbnlw 28 31 or or CC cord-339015-qn8wbnlw 28 32 a a DT cord-339015-qn8wbnlw 28 33 quinolone quinolone NNP cord-339015-qn8wbnlw 28 34 APPs app NNS cord-339015-qn8wbnlw 28 35 working work VBG cord-339015-qn8wbnlw 28 36 in in IN cord-339015-qn8wbnlw 28 37 the the DT cord-339015-qn8wbnlw 28 38 ICU ICU NNP cord-339015-qn8wbnlw 28 39 should should MD cord-339015-qn8wbnlw 28 40 optimize optimize VB cord-339015-qn8wbnlw 28 41 dosing dosing NN cord-339015-qn8wbnlw 28 42 , , , cord-339015-qn8wbnlw 28 43 frequency frequency NN cord-339015-qn8wbnlw 28 44 , , , cord-339015-qn8wbnlw 28 45 and and CC cord-339015-qn8wbnlw 28 46 longer long JJR cord-339015-qn8wbnlw 28 47 infusion infusion NN cord-339015-qn8wbnlw 28 48 time time NN cord-339015-qn8wbnlw 28 49 . . . cord-339015-qn8wbnlw 29 1 It -PRON- PRP cord-339015-qn8wbnlw 29 2 is be VBZ cord-339015-qn8wbnlw 29 3 good good JJ cord-339015-qn8wbnlw 29 4 practice practice NN cord-339015-qn8wbnlw 29 5 to to TO cord-339015-qn8wbnlw 29 6 combine combine VB cord-339015-qn8wbnlw 29 7 time time NN cord-339015-qn8wbnlw 29 8 - - HYPH cord-339015-qn8wbnlw 29 9 dependent dependent JJ cord-339015-qn8wbnlw 29 10 antibiotics antibiotic NNS cord-339015-qn8wbnlw 29 11 , , , cord-339015-qn8wbnlw 29 12 including include VBG cord-339015-qn8wbnlw 29 13 piperacillin piperacillin NNP cord-339015-qn8wbnlw 29 14 / / SYM cord-339015-qn8wbnlw 29 15 tazobactam tazobactam NNP cord-339015-qn8wbnlw 29 16 , , , cord-339015-qn8wbnlw 29 17 cefepime cefepime NNP cord-339015-qn8wbnlw 29 18 , , , cord-339015-qn8wbnlw 29 19 and and CC cord-339015-qn8wbnlw 29 20 imipenem imipenem NNP cord-339015-qn8wbnlw 29 21 , , , cord-339015-qn8wbnlw 29 22 with with IN cord-339015-qn8wbnlw 29 23 concentration concentration NN cord-339015-qn8wbnlw 29 24 - - HYPH cord-339015-qn8wbnlw 29 25 dependent dependent JJ cord-339015-qn8wbnlw 29 26 antibiotics antibiotic NNS cord-339015-qn8wbnlw 29 27 , , , cord-339015-qn8wbnlw 29 28 such such JJ cord-339015-qn8wbnlw 29 29 as as IN cord-339015-qn8wbnlw 29 30 ciprofloxacin ciprofloxacin NN cord-339015-qn8wbnlw 29 31 or or CC cord-339015-qn8wbnlw 29 32 levofloxacin levofloxacin NNS cord-339015-qn8wbnlw 29 33 . . . cord-339015-qn8wbnlw 30 1 Acinetobacter Acinetobacter NNP cord-339015-qn8wbnlw 30 2 baumannii baumannii NNP cord-339015-qn8wbnlw 30 3 is be VBZ cord-339015-qn8wbnlw 30 4 also also RB cord-339015-qn8wbnlw 30 5 a a DT cord-339015-qn8wbnlw 30 6 major major JJ cord-339015-qn8wbnlw 30 7 cause cause NN cord-339015-qn8wbnlw 30 8 of of IN cord-339015-qn8wbnlw 30 9 VAP VAP NNP cord-339015-qn8wbnlw 30 10 and and CC cord-339015-qn8wbnlw 30 11 bloodstream bloodstream NN cord-339015-qn8wbnlw 30 12 infections infection NNS cord-339015-qn8wbnlw 30 13 . . . cord-339015-qn8wbnlw 31 1 Risk risk NN cord-339015-qn8wbnlw 31 2 factors factor NNS cord-339015-qn8wbnlw 31 3 include include VBP cord-339015-qn8wbnlw 31 4 longer long JJR cord-339015-qn8wbnlw 31 5 ICU ICU NNP cord-339015-qn8wbnlw 31 6 stay stay NN cord-339015-qn8wbnlw 31 7 , , , cord-339015-qn8wbnlw 31 8 recent recent JJ cord-339015-qn8wbnlw 31 9 surgery surgery NN cord-339015-qn8wbnlw 31 10 , , , cord-339015-qn8wbnlw 31 11 mechanical mechanical JJ cord-339015-qn8wbnlw 31 12 ventilation ventilation NN cord-339015-qn8wbnlw 31 13 , , , cord-339015-qn8wbnlw 31 14 prior prior JJ cord-339015-qn8wbnlw 31 15 antibiotic antibiotic JJ cord-339015-qn8wbnlw 31 16 exposure exposure NN cord-339015-qn8wbnlw 31 17 . . . cord-339015-qn8wbnlw 32 1 Data datum NNS cord-339015-qn8wbnlw 32 2 from from IN cord-339015-qn8wbnlw 32 3 the the DT cord-339015-qn8wbnlw 32 4 National National NNP cord-339015-qn8wbnlw 32 5 Nosocomial Nosocomial NNP cord-339015-qn8wbnlw 32 6 Infections Infections NNPS cord-339015-qn8wbnlw 32 7 Surveillance Surveillance NNP cord-339015-qn8wbnlw 32 8 System System NNP cord-339015-qn8wbnlw 32 9 indicate indicate VBP cord-339015-qn8wbnlw 32 10 that that IN cord-339015-qn8wbnlw 32 11 resistance resistance NN cord-339015-qn8wbnlw 32 12 of of IN cord-339015-qn8wbnlw 32 13 Acinetobacter Acinetobacter NNP cord-339015-qn8wbnlw 32 14 species specie NNS cord-339015-qn8wbnlw 32 15 is be VBZ cord-339015-qn8wbnlw 32 16 on on IN cord-339015-qn8wbnlw 32 17 the the DT cord-339015-qn8wbnlw 32 18 rise rise NN cord-339015-qn8wbnlw 32 19 . . . cord-339015-qn8wbnlw 33 1 8 8 CD cord-339015-qn8wbnlw 34 1 For for IN cord-339015-qn8wbnlw 34 2 the the DT cord-339015-qn8wbnlw 34 3 treatment treatment NN cord-339015-qn8wbnlw 34 4 of of IN cord-339015-qn8wbnlw 34 5 susceptible susceptible JJ cord-339015-qn8wbnlw 34 6 isolates isolate NNS cord-339015-qn8wbnlw 34 7 of of IN cord-339015-qn8wbnlw 34 8 Acinetobacter Acinetobacter NNP cord-339015-qn8wbnlw 34 9 , , , cord-339015-qn8wbnlw 34 10 APPs app NNS cord-339015-qn8wbnlw 34 11 can can MD cord-339015-qn8wbnlw 34 12 use use VB cord-339015-qn8wbnlw 34 13 Broad Broad NNP cord-339015-qn8wbnlw 34 14 - - HYPH cord-339015-qn8wbnlw 34 15 spectrum spectrum NN cord-339015-qn8wbnlw 34 16 cephalosporins cephalosporin NNS cord-339015-qn8wbnlw 34 17 b b NN cord-339015-qn8wbnlw 34 18 - - HYPH cord-339015-qn8wbnlw 34 19 lactam lactam NN cord-339015-qn8wbnlw 34 20 - - HYPH cord-339015-qn8wbnlw 34 21 b b NN cord-339015-qn8wbnlw 34 22 - - HYPH cord-339015-qn8wbnlw 34 23 lactamase lactamase NN cord-339015-qn8wbnlw 34 24 inhibitor inhibitor NN cord-339015-qn8wbnlw 34 25 combinations combination NNS cord-339015-qn8wbnlw 35 1 Carbapenems Carbapenems NNP cord-339015-qn8wbnlw 35 2 Box Box NNP cord-339015-qn8wbnlw 35 3 1 1 CD cord-339015-qn8wbnlw 35 4 Antimicrobial Antimicrobial NNP cord-339015-qn8wbnlw 35 5 resistance resistance NN cord-339015-qn8wbnlw 35 6 and and CC cord-339015-qn8wbnlw 35 7 optimizing optimize VBG cord-339015-qn8wbnlw 35 8 antibiotic antibiotic JJ cord-339015-qn8wbnlw 35 9 use use NN cord-339015-qn8wbnlw 35 10 in in IN cord-339015-qn8wbnlw 35 11 the the DT cord-339015-qn8wbnlw 35 12 ICU ICU NNP cord-339015-qn8wbnlw 36 1 The the DT cord-339015-qn8wbnlw 36 2 prevalence prevalence NN cord-339015-qn8wbnlw 36 3 of of IN cord-339015-qn8wbnlw 36 4 multidrug multidrug NN cord-339015-qn8wbnlw 36 5 - - HYPH cord-339015-qn8wbnlw 36 6 resistant resistant JJ cord-339015-qn8wbnlw 36 7 organisms organism NNS cord-339015-qn8wbnlw 36 8 is be VBZ cord-339015-qn8wbnlw 36 9 increasing increase VBG cord-339015-qn8wbnlw 36 10 in in IN cord-339015-qn8wbnlw 36 11 the the DT cord-339015-qn8wbnlw 36 12 ICU ICU NNP cord-339015-qn8wbnlw 36 13 , , , cord-339015-qn8wbnlw 36 14 4,5 4,5 CD cord-339015-qn8wbnlw 36 15 leading lead VBG cord-339015-qn8wbnlw 36 16 to to IN cord-339015-qn8wbnlw 36 17 increased increase VBN cord-339015-qn8wbnlw 36 18 mortality mortality NN cord-339015-qn8wbnlw 36 19 , , , cord-339015-qn8wbnlw 36 20 longer long JJR cord-339015-qn8wbnlw 36 21 hospital hospital NN cord-339015-qn8wbnlw 36 22 stays stay NNS cord-339015-qn8wbnlw 36 23 , , , cord-339015-qn8wbnlw 36 24 and and CC cord-339015-qn8wbnlw 36 25 higher high JJR cord-339015-qn8wbnlw 36 26 costs cost NNS cord-339015-qn8wbnlw 36 27 . . . cord-339015-qn8wbnlw 37 1 The the DT cord-339015-qn8wbnlw 37 2 emergence emergence NN cord-339015-qn8wbnlw 37 3 of of IN cord-339015-qn8wbnlw 37 4 resistance resistance NN cord-339015-qn8wbnlw 37 5 among among IN cord-339015-qn8wbnlw 37 6 gram gram NN cord-339015-qn8wbnlw 37 7 - - HYPH cord-339015-qn8wbnlw 37 8 negative negative JJ cord-339015-qn8wbnlw 37 9 bacteria bacteria NNS cord-339015-qn8wbnlw 37 10 has have VBZ cord-339015-qn8wbnlw 37 11 significant significant JJ cord-339015-qn8wbnlw 37 12 implications implication NNS cord-339015-qn8wbnlw 37 13 because because IN cord-339015-qn8wbnlw 37 14 there there EX cord-339015-qn8wbnlw 37 15 are be VBP cord-339015-qn8wbnlw 37 16 not not RB cord-339015-qn8wbnlw 37 17 many many JJ cord-339015-qn8wbnlw 37 18 therapeutic therapeutic JJ cord-339015-qn8wbnlw 37 19 options option NNS cord-339015-qn8wbnlw 37 20 . . . cord-339015-qn8wbnlw 38 1 The the DT cord-339015-qn8wbnlw 38 2 most most RBS cord-339015-qn8wbnlw 38 3 encountered encounter VBN cord-339015-qn8wbnlw 38 4 resistant resistant JJ cord-339015-qn8wbnlw 38 5 pathogens pathogen NNS cord-339015-qn8wbnlw 38 6 include include VBP cord-339015-qn8wbnlw 38 7 MRSA MRSA NNP cord-339015-qn8wbnlw 38 8 , , , cord-339015-qn8wbnlw 38 9 vancomycin vancomycin NN cord-339015-qn8wbnlw 38 10 - - HYPH cord-339015-qn8wbnlw 38 11 resistant resistant JJ cord-339015-qn8wbnlw 38 12 enterococcus enterococcus NN cord-339015-qn8wbnlw 38 13 , , , cord-339015-qn8wbnlw 38 14 Enterobacteriaceae Enterobacteriaceae NNP cord-339015-qn8wbnlw 38 15 ( ( -LRB- cord-339015-qn8wbnlw 38 16 ESBLs esbl NNS cord-339015-qn8wbnlw 38 17 ) ) -RRB- cord-339015-qn8wbnlw 38 18 , , , cord-339015-qn8wbnlw 38 19 P. P. NNP cord-339015-qn8wbnlw 38 20 aeruginosa aeruginosa NN cord-339015-qn8wbnlw 38 21 resistant resistant JJ cord-339015-qn8wbnlw 38 22 to to IN cord-339015-qn8wbnlw 38 23 imipenem imipenem NNP cord-339015-qn8wbnlw 38 24 , , , cord-339015-qn8wbnlw 38 25 and and CC cord-339015-qn8wbnlw 38 26 fluoroquinolones fluoroquinolone NNS cord-339015-qn8wbnlw 38 27 . . . cord-339015-qn8wbnlw 39 1 Features feature NNS cord-339015-qn8wbnlw 39 2 Optimizing optimize VBG cord-339015-qn8wbnlw 39 3 antibiotic antibiotic JJ cord-339015-qn8wbnlw 39 4 therapy therapy NN cord-339015-qn8wbnlw 39 5 in in IN cord-339015-qn8wbnlw 39 6 the the DT cord-339015-qn8wbnlw 39 7 ICU ICU NNP cord-339015-qn8wbnlw 39 8 Principles Principles NNPS cord-339015-qn8wbnlw 39 9 governing govern VBG cord-339015-qn8wbnlw 39 10 antimicrobial antimicrobial JJ cord-339015-qn8wbnlw 39 11 therapy therapy NN cord-339015-qn8wbnlw 39 12 in in IN cord-339015-qn8wbnlw 39 13 the the DT cord-339015-qn8wbnlw 39 14 ICU ICU NNP cord-339015-qn8wbnlw 39 15 include include VBP cord-339015-qn8wbnlw 39 16 Ensuring ensure VBG cord-339015-qn8wbnlw 39 17 adequacy adequacy NN cord-339015-qn8wbnlw 39 18 of of IN cord-339015-qn8wbnlw 39 19 the the DT cord-339015-qn8wbnlw 39 20 initial initial JJ cord-339015-qn8wbnlw 39 21 empiric empiric JJ cord-339015-qn8wbnlw 39 22 therapy therapy NN cord-339015-qn8wbnlw 39 23 5 5 CD cord-339015-qn8wbnlw 39 24 Timing timing NN cord-339015-qn8wbnlw 39 25 and and CC cord-339015-qn8wbnlw 39 26 rapid rapid JJ cord-339015-qn8wbnlw 39 27 initiation initiation NN cord-339015-qn8wbnlw 39 28 of of IN cord-339015-qn8wbnlw 39 29 empiric empiric JJ cord-339015-qn8wbnlw 39 30 broad broad JJ cord-339015-qn8wbnlw 39 31 empiric empiric JJ cord-339015-qn8wbnlw 39 32 broad broad JJ cord-339015-qn8wbnlw 39 33 antibiotics antibiotic NNS cord-339015-qn8wbnlw 39 34 Source source NN cord-339015-qn8wbnlw 39 35 - - HYPH cord-339015-qn8wbnlw 39 36 targeted target VBN cord-339015-qn8wbnlw 39 37 and and CC cord-339015-qn8wbnlw 39 38 tissue tissue NN cord-339015-qn8wbnlw 39 39 - - HYPH cord-339015-qn8wbnlw 39 40 targeted target VBN cord-339015-qn8wbnlw 39 41 therapy therapy NN cord-339015-qn8wbnlw 39 42 ( ( -LRB- cord-339015-qn8wbnlw 39 43 eg eg RB cord-339015-qn8wbnlw 39 44 , , , cord-339015-qn8wbnlw 39 45 lungs lung NNS cord-339015-qn8wbnlw 39 46 , , , cord-339015-qn8wbnlw 39 47 urinary urinary JJ cord-339015-qn8wbnlw 39 48 tract tract NN cord-339015-qn8wbnlw 39 49 , , , cord-339015-qn8wbnlw 39 50 catheter catheter NN cord-339015-qn8wbnlw 39 51 , , , cord-339015-qn8wbnlw 39 52 and and CC cord-339015-qn8wbnlw 39 53 abdomen abdomen NN cord-339015-qn8wbnlw 39 54 ) ) -RRB- cord-339015-qn8wbnlw 40 1 Narrow narrow JJ cord-339015-qn8wbnlw 40 2 antimicrobial antimicrobial JJ cord-339015-qn8wbnlw 40 3 choices choice NNS cord-339015-qn8wbnlw 40 4 based base VBN cord-339015-qn8wbnlw 40 5 on on IN cord-339015-qn8wbnlw 40 6 microbiology microbiology NN cord-339015-qn8wbnlw 40 7 and and CC cord-339015-qn8wbnlw 40 8 epidemiology epidemiology NN cord-339015-qn8wbnlw 40 9 data datum NNS cord-339015-qn8wbnlw 41 1 Considering consider VBG cord-339015-qn8wbnlw 41 2 host host NN cord-339015-qn8wbnlw 41 3 factors factor NNS cord-339015-qn8wbnlw 41 4 , , , cord-339015-qn8wbnlw 41 5 such such JJ cord-339015-qn8wbnlw 41 6 as as IN cord-339015-qn8wbnlw 41 7 immunosuppression immunosuppression NN cord-339015-qn8wbnlw 41 8 and and CC cord-339015-qn8wbnlw 41 9 comorbidities comorbiditie NNS cord-339015-qn8wbnlw 41 10 Initial initial JJ cord-339015-qn8wbnlw 41 11 patient patient JJ cord-339015-qn8wbnlw 41 12 response response NN cord-339015-qn8wbnlw 41 13 that that WDT cord-339015-qn8wbnlw 41 14 should should MD cord-339015-qn8wbnlw 41 15 guide guide VB cord-339015-qn8wbnlw 41 16 need need VB cord-339015-qn8wbnlw 41 17 for for IN cord-339015-qn8wbnlw 41 18 further further JJ cord-339015-qn8wbnlw 41 19 work work NN cord-339015-qn8wbnlw 41 20 or or CC cord-339015-qn8wbnlw 41 21 antibiotic antibiotic JJ cord-339015-qn8wbnlw 41 22 duration duration NN cord-339015-qn8wbnlw 41 23 Treating treat VBG cord-339015-qn8wbnlw 41 24 for for IN cord-339015-qn8wbnlw 41 25 the the DT cord-339015-qn8wbnlw 41 26 shortest short JJS cord-339015-qn8wbnlw 41 27 effective effective JJ cord-339015-qn8wbnlw 41 28 duration duration NN cord-339015-qn8wbnlw 41 29 6 6 CD cord-339015-qn8wbnlw 41 30 Avoiding avoid VBG cord-339015-qn8wbnlw 41 31 unnecessary unnecessary JJ cord-339015-qn8wbnlw 41 32 combination combination NN cord-339015-qn8wbnlw 41 33 therapy therapy NN cord-339015-qn8wbnlw 41 34 For for IN cord-339015-qn8wbnlw 41 35 multidrug multidrug NN cord-339015-qn8wbnlw 41 36 - - HYPH cord-339015-qn8wbnlw 41 37 resistant resistant JJ cord-339015-qn8wbnlw 41 38 Acinetobacter Acinetobacter NNP cord-339015-qn8wbnlw 41 39 isolates isolate NNS cord-339015-qn8wbnlw 41 40 , , , cord-339015-qn8wbnlw 41 41 APPs app NNS cord-339015-qn8wbnlw 41 42 can can MD cord-339015-qn8wbnlw 41 43 use use VB cord-339015-qn8wbnlw 41 44 Polymyxins Polymyxins NNP cord-339015-qn8wbnlw 41 45 , , , cord-339015-qn8wbnlw 41 46 such such JJ cord-339015-qn8wbnlw 41 47 as as IN cord-339015-qn8wbnlw 41 48 colistin colistin NNP cord-339015-qn8wbnlw 41 49 Minocycline Minocycline NNP cord-339015-qn8wbnlw 41 50 Tigecycline Tigecycline NNP cord-339015-qn8wbnlw 41 51 Critically critically RB cord-339015-qn8wbnlw 41 52 ill ill JJ cord-339015-qn8wbnlw 41 53 and and CC cord-339015-qn8wbnlw 41 54 immunocompromised immunocompromised JJ cord-339015-qn8wbnlw 41 55 patients patient NNS cord-339015-qn8wbnlw 41 56 are be VBP cord-339015-qn8wbnlw 41 57 at at IN cord-339015-qn8wbnlw 41 58 increased increase VBN cord-339015-qn8wbnlw 41 59 risk risk NN cord-339015-qn8wbnlw 41 60 for for IN cord-339015-qn8wbnlw 41 61 community community NN cord-339015-qn8wbnlw 41 62 - - HYPH cord-339015-qn8wbnlw 41 63 acquired acquire VBN cord-339015-qn8wbnlw 41 64 , , , cord-339015-qn8wbnlw 41 65 opportunistic opportunistic JJ cord-339015-qn8wbnlw 41 66 , , , cord-339015-qn8wbnlw 41 67 and and CC cord-339015-qn8wbnlw 41 68 nosocomial nosocomial JJ cord-339015-qn8wbnlw 41 69 infections infection NNS cord-339015-qn8wbnlw 41 70 . . . cord-339015-qn8wbnlw 42 1 Immunocompromised immunocompromise VBN cord-339015-qn8wbnlw 42 2 hosts host NNS cord-339015-qn8wbnlw 42 3 include include VBP cord-339015-qn8wbnlw 42 4 patients patient NNS cord-339015-qn8wbnlw 42 5 with with IN cord-339015-qn8wbnlw 42 6 neutropenia neutropenia NN cord-339015-qn8wbnlw 42 7 or or CC cord-339015-qn8wbnlw 42 8 hematologic hematologic JJ cord-339015-qn8wbnlw 42 9 malignancy malignancy NN cord-339015-qn8wbnlw 42 10 ; ; : cord-339015-qn8wbnlw 42 11 those those DT cord-339015-qn8wbnlw 42 12 patients patient NNS cord-339015-qn8wbnlw 42 13 on on IN cord-339015-qn8wbnlw 42 14 corticosteroids corticosteroid NNS cord-339015-qn8wbnlw 42 15 and and CC cord-339015-qn8wbnlw 42 16 other other JJ cord-339015-qn8wbnlw 42 17 forms form NNS cord-339015-qn8wbnlw 42 18 of of IN cord-339015-qn8wbnlw 42 19 immunosuppressive immunosuppressive JJ cord-339015-qn8wbnlw 42 20 therapy therapy NN cord-339015-qn8wbnlw 42 21 ; ; , cord-339015-qn8wbnlw 42 22 solid solid JJ cord-339015-qn8wbnlw 42 23 transplant transplant NN cord-339015-qn8wbnlw 42 24 patients patient NNS cord-339015-qn8wbnlw 42 25 ; ; : cord-339015-qn8wbnlw 42 26 patients patient NNS cord-339015-qn8wbnlw 42 27 with with IN cord-339015-qn8wbnlw 42 28 hematopoietic hematopoietic JJ cord-339015-qn8wbnlw 42 29 stem stem NN cord-339015-qn8wbnlw 42 30 transplant transplant NN cord-339015-qn8wbnlw 42 31 , , , cord-339015-qn8wbnlw 42 32 HIV HIV NNP cord-339015-qn8wbnlw 42 33 / / SYM cord-339015-qn8wbnlw 42 34 AIDS AIDS NNP cord-339015-qn8wbnlw 42 35 , , , cord-339015-qn8wbnlw 42 36 or or CC cord-339015-qn8wbnlw 42 37 asplenia asplenia NN cord-339015-qn8wbnlw 42 38 ; ; : cord-339015-qn8wbnlw 42 39 and and CC cord-339015-qn8wbnlw 42 40 patients patient NNS cord-339015-qn8wbnlw 42 41 on on IN cord-339015-qn8wbnlw 42 42 biologic biologic JJ cord-339015-qn8wbnlw 42 43 agents agent NNS cord-339015-qn8wbnlw 42 44 , , , cord-339015-qn8wbnlw 42 45 such such JJ cord-339015-qn8wbnlw 42 46 as as IN cord-339015-qn8wbnlw 42 47 tumor tumor NN cord-339015-qn8wbnlw 42 48 necrosis necrosis NN cord-339015-qn8wbnlw 42 49 factor factor NN cord-339015-qn8wbnlw 43 1 l. l. NNP cord-339015-qn8wbnlw 44 1 The the DT cord-339015-qn8wbnlw 44 2 attenuated attenuated JJ cord-339015-qn8wbnlw 44 3 inflammatory inflammatory JJ cord-339015-qn8wbnlw 44 4 response response NN cord-339015-qn8wbnlw 44 5 in in IN cord-339015-qn8wbnlw 44 6 these these DT cord-339015-qn8wbnlw 44 7 patients patient NNS cord-339015-qn8wbnlw 44 8 make make VBP cord-339015-qn8wbnlw 44 9 it -PRON- PRP cord-339015-qn8wbnlw 44 10 difficult difficult JJ cord-339015-qn8wbnlw 44 11 to to TO cord-339015-qn8wbnlw 44 12 make make VB cord-339015-qn8wbnlw 44 13 an an DT cord-339015-qn8wbnlw 44 14 early early JJ cord-339015-qn8wbnlw 44 15 diagnosis diagnosis NN cord-339015-qn8wbnlw 44 16 because because IN cord-339015-qn8wbnlw 44 17 clinical clinical JJ cord-339015-qn8wbnlw 44 18 signs sign NNS cord-339015-qn8wbnlw 44 19 and and CC cord-339015-qn8wbnlw 44 20 symptoms symptom NNS cord-339015-qn8wbnlw 44 21 are be VBP cord-339015-qn8wbnlw 44 22 frequently frequently RB cord-339015-qn8wbnlw 44 23 atypical atypical JJ cord-339015-qn8wbnlw 44 24 and and CC cord-339015-qn8wbnlw 44 25 nonspecific nonspecific JJ cord-339015-qn8wbnlw 44 26 . . . cord-339015-qn8wbnlw 45 1 Because because IN cord-339015-qn8wbnlw 45 2 these these DT cord-339015-qn8wbnlw 45 3 patients patient NNS cord-339015-qn8wbnlw 45 4 are be VBP cord-339015-qn8wbnlw 45 5 always always RB cord-339015-qn8wbnlw 45 6 put put VBN cord-339015-qn8wbnlw 45 7 on on RP cord-339015-qn8wbnlw 45 8 various various JJ cord-339015-qn8wbnlw 45 9 prophylactic prophylactic JJ cord-339015-qn8wbnlw 45 10 antimicrobials antimicrobial NNS cord-339015-qn8wbnlw 45 11 and and CC cord-339015-qn8wbnlw 45 12 have have VBP cord-339015-qn8wbnlw 45 13 multiple multiple JJ cord-339015-qn8wbnlw 45 14 hospitalizations hospitalization NNS cord-339015-qn8wbnlw 45 15 , , , cord-339015-qn8wbnlw 45 16 they -PRON- PRP cord-339015-qn8wbnlw 45 17 are be VBP cord-339015-qn8wbnlw 45 18 also also RB cord-339015-qn8wbnlw 45 19 at at IN cord-339015-qn8wbnlw 45 20 increased increase VBN cord-339015-qn8wbnlw 45 21 risk risk NN cord-339015-qn8wbnlw 45 22 for for IN cord-339015-qn8wbnlw 45 23 multidrug multidrug NN cord-339015-qn8wbnlw 45 24 - - HYPH cord-339015-qn8wbnlw 45 25 resistant resistant JJ cord-339015-qn8wbnlw 45 26 organisms organism NNS cord-339015-qn8wbnlw 45 27 . . . cord-339015-qn8wbnlw 46 1 Most Most JJS cord-339015-qn8wbnlw 46 2 infections infection NNS cord-339015-qn8wbnlw 46 3 in in IN cord-339015-qn8wbnlw 46 4 the the DT cord-339015-qn8wbnlw 46 5 immunocompromised immunocompromised JJ cord-339015-qn8wbnlw 46 6 patients patient NNS cord-339015-qn8wbnlw 46 7 present present JJ cord-339015-qn8wbnlw 46 8 in in IN cord-339015-qn8wbnlw 46 9 a a DT cord-339015-qn8wbnlw 46 10 hierarchical hierarchical JJ cord-339015-qn8wbnlw 46 11 pattern pattern NN cord-339015-qn8wbnlw 46 12 depending depend VBG cord-339015-qn8wbnlw 46 13 on on IN cord-339015-qn8wbnlw 46 14 the the DT cord-339015-qn8wbnlw 46 15 level level NN cord-339015-qn8wbnlw 46 16 of of IN cord-339015-qn8wbnlw 46 17 immunosuppression immunosuppression NN cord-339015-qn8wbnlw 46 18 , , , cord-339015-qn8wbnlw 46 19 neutropenia neutropenia NN cord-339015-qn8wbnlw 46 20 , , , cord-339015-qn8wbnlw 46 21 and and CC cord-339015-qn8wbnlw 46 22 CD4 CD4 NNP cord-339015-qn8wbnlw 46 23 counts count VBZ cord-339015-qn8wbnlw 46 24 . . . cord-339015-qn8wbnlw 47 1 Because because IN cord-339015-qn8wbnlw 47 2 morbidity morbidity NN cord-339015-qn8wbnlw 47 3 and and CC cord-339015-qn8wbnlw 47 4 mortality mortality NN cord-339015-qn8wbnlw 47 5 are be VBP cord-339015-qn8wbnlw 47 6 very very RB cord-339015-qn8wbnlw 47 7 high high JJ cord-339015-qn8wbnlw 47 8 , , , cord-339015-qn8wbnlw 47 9 early early JJ cord-339015-qn8wbnlw 47 10 empiric empiric JJ cord-339015-qn8wbnlw 47 11 antimicrobial antimicrobial JJ cord-339015-qn8wbnlw 47 12 therapy therapy NN cord-339015-qn8wbnlw 47 13 is be VBZ cord-339015-qn8wbnlw 47 14 universally universally RB cord-339015-qn8wbnlw 47 15 indicated indicate VBN cord-339015-qn8wbnlw 47 16 . . . cord-339015-qn8wbnlw 48 1 Bacterial bacterial JJ cord-339015-qn8wbnlw 48 2 pneumonia pneumonia NN cord-339015-qn8wbnlw 48 3 , , , cord-339015-qn8wbnlw 48 4 bacteremia bacteremia NN cord-339015-qn8wbnlw 48 5 , , , cord-339015-qn8wbnlw 48 6 gastrointestinal gastrointestinal JJ cord-339015-qn8wbnlw 48 7 ( ( -LRB- cord-339015-qn8wbnlw 48 8 GI GI NNP cord-339015-qn8wbnlw 48 9 ) ) -RRB- cord-339015-qn8wbnlw 48 10 , , , cord-339015-qn8wbnlw 48 11 and and CC cord-339015-qn8wbnlw 48 12 central central JJ cord-339015-qn8wbnlw 48 13 nervous nervous JJ cord-339015-qn8wbnlw 48 14 system system NN cord-339015-qn8wbnlw 48 15 infections infection NNS cord-339015-qn8wbnlw 48 16 occur occur VBP cord-339015-qn8wbnlw 48 17 at at IN cord-339015-qn8wbnlw 48 18 high high JJ cord-339015-qn8wbnlw 48 19 frequency frequency NN cord-339015-qn8wbnlw 48 20 in in IN cord-339015-qn8wbnlw 48 21 HIV HIV NNP cord-339015-qn8wbnlw 48 22 / / SYM cord-339015-qn8wbnlw 48 23 AIDS AIDS NNP cord-339015-qn8wbnlw 48 24 patients patient NNS cord-339015-qn8wbnlw 48 25 , , , cord-339015-qn8wbnlw 48 26 depending depend VBG cord-339015-qn8wbnlw 48 27 on on IN cord-339015-qn8wbnlw 48 28 CD4 CD4 NNP cord-339015-qn8wbnlw 48 29 1 1 CD cord-339015-qn8wbnlw 48 30 levels level NNS cord-339015-qn8wbnlw 48 31 . . . cord-339015-qn8wbnlw 49 1 Common common JJ cord-339015-qn8wbnlw 49 2 pathogens pathogen NNS cord-339015-qn8wbnlw 49 3 include include VBP cord-339015-qn8wbnlw 49 4 Mycobacterium Mycobacterium NNP cord-339015-qn8wbnlw 49 5 tuberculosis tuberculosis NN cord-339015-qn8wbnlw 49 6 , , , cord-339015-qn8wbnlw 49 7 pneumocystis pneumocystis NN cord-339015-qn8wbnlw 49 8 , , , cord-339015-qn8wbnlw 49 9 P. P. NNP cord-339015-qn8wbnlw 49 10 aeruginosa aeruginosa NN cord-339015-qn8wbnlw 49 11 , , , cord-339015-qn8wbnlw 49 12 endemic endemic JJ cord-339015-qn8wbnlw 49 13 mycoses mycose NNS cord-339015-qn8wbnlw 49 14 , , , cord-339015-qn8wbnlw 49 15 Candida Candida NNP cord-339015-qn8wbnlw 49 16 species specie NNS cord-339015-qn8wbnlw 49 17 , , , cord-339015-qn8wbnlw 49 18 Histoplasma Histoplasma NNP cord-339015-qn8wbnlw 49 19 capsulatum capsulatum NN cord-339015-qn8wbnlw 49 20 , , , cord-339015-qn8wbnlw 49 21 Coccidioides Coccidioides NNP cord-339015-qn8wbnlw 49 22 species specie NNS cord-339015-qn8wbnlw 49 23 , , , cord-339015-qn8wbnlw 49 24 Toxoplasma toxoplasma NN cord-339015-qn8wbnlw 49 25 gondii gondii NN cord-339015-qn8wbnlw 49 26 , , , cord-339015-qn8wbnlw 49 27 and and CC cord-339015-qn8wbnlw 49 28 Listeria Listeria NNP cord-339015-qn8wbnlw 49 29 monocytogenes monocytogenes NNP cord-339015-qn8wbnlw 49 30 . . . cord-339015-qn8wbnlw 50 1 Pathogens pathogen NNS cord-339015-qn8wbnlw 50 2 frequently frequently RB cord-339015-qn8wbnlw 50 3 encountered encounter VBD cord-339015-qn8wbnlw 50 4 when when WRB cord-339015-qn8wbnlw 50 5 the the DT cord-339015-qn8wbnlw 50 6 CD4 CD4 NNP cord-339015-qn8wbnlw 50 7 1 1 CD cord-339015-qn8wbnlw 50 8 levels level NNS cord-339015-qn8wbnlw 50 9 less less JJR cord-339015-qn8wbnlw 50 10 than than IN cord-339015-qn8wbnlw 50 11 50 50 CD cord-339015-qn8wbnlw 50 12 include include VBP cord-339015-qn8wbnlw 50 13 mycobacterium mycobacterium NN cord-339015-qn8wbnlw 50 14 avium avium NN cord-339015-qn8wbnlw 50 15 complex complex NN cord-339015-qn8wbnlw 50 16 , , , cord-339015-qn8wbnlw 50 17 Cryptococcus Cryptococcus NNP cord-339015-qn8wbnlw 50 18 neoformans neoforman VBZ cord-339015-qn8wbnlw 50 19 , , , cord-339015-qn8wbnlw 50 20 CMV CMV NNP cord-339015-qn8wbnlw 50 21 , , , cord-339015-qn8wbnlw 50 22 herpes herpes NN cord-339015-qn8wbnlw 50 23 simplex simplex NN cord-339015-qn8wbnlw 50 24 virus virus NN cord-339015-qn8wbnlw 50 25 ( ( -LRB- cord-339015-qn8wbnlw 50 26 HSV HSV NNP cord-339015-qn8wbnlw 50 27 ) ) -RRB- cord-339015-qn8wbnlw 50 28 , , , cord-339015-qn8wbnlw 50 29 and and CC cord-339015-qn8wbnlw 50 30 varicella varicella NN cord-339015-qn8wbnlw 50 31 - - HYPH cord-339015-qn8wbnlw 50 32 zoster zoster NN cord-339015-qn8wbnlw 50 33 virus virus NN cord-339015-qn8wbnlw 50 34 ( ( -LRB- cord-339015-qn8wbnlw 50 35 VZV VZV NNP cord-339015-qn8wbnlw 50 36 ) ) -RRB- cord-339015-qn8wbnlw 50 37 , , , cord-339015-qn8wbnlw 50 38 although although IN cord-339015-qn8wbnlw 50 39 the the DT cord-339015-qn8wbnlw 50 40 advent advent NN cord-339015-qn8wbnlw 50 41 of of IN cord-339015-qn8wbnlw 50 42 antiretroviral antiretroviral JJ cord-339015-qn8wbnlw 50 43 therapy therapy NN cord-339015-qn8wbnlw 50 44 has have VBZ cord-339015-qn8wbnlw 50 45 reduced reduce VBN cord-339015-qn8wbnlw 50 46 the the DT cord-339015-qn8wbnlw 50 47 incidence incidence NN cord-339015-qn8wbnlw 50 48 of of IN cord-339015-qn8wbnlw 50 49 these these DT cord-339015-qn8wbnlw 50 50 pathogens pathogen NNS cord-339015-qn8wbnlw 50 51 . . . cord-339015-qn8wbnlw 51 1 S s NN cord-339015-qn8wbnlw 51 2 aureus aureus NN cord-339015-qn8wbnlw 51 3 , , , cord-339015-qn8wbnlw 51 4 Streptococcus streptococcus NN cord-339015-qn8wbnlw 51 5 pneumoniae pneumoniae NN cord-339015-qn8wbnlw 51 6 , , , cord-339015-qn8wbnlw 51 7 and and CC cord-339015-qn8wbnlw 51 8 Haemophilus haemophilus JJ cord-339015-qn8wbnlw 51 9 influenzae influenzae NN cord-339015-qn8wbnlw 51 10 are be VBP cord-339015-qn8wbnlw 51 11 the the DT cord-339015-qn8wbnlw 51 12 most most RBS cord-339015-qn8wbnlw 51 13 common common JJ cord-339015-qn8wbnlw 51 14 fatal fatal JJ cord-339015-qn8wbnlw 51 15 bacterial bacterial JJ cord-339015-qn8wbnlw 51 16 infection infection NN cord-339015-qn8wbnlw 51 17 in in IN cord-339015-qn8wbnlw 51 18 these these DT cord-339015-qn8wbnlw 51 19 patients patient NNS cord-339015-qn8wbnlw 51 20 irrespective irrespective RB cord-339015-qn8wbnlw 51 21 of of IN cord-339015-qn8wbnlw 51 22 CD4 CD4 NNP cord-339015-qn8wbnlw 51 23 1 1 CD cord-339015-qn8wbnlw 51 24 levels level NNS cord-339015-qn8wbnlw 51 25 . . . cord-339015-qn8wbnlw 52 1 Diarrhea diarrhea NN cord-339015-qn8wbnlw 52 2 in in IN cord-339015-qn8wbnlw 52 3 HIV HIV NNP cord-339015-qn8wbnlw 52 4 / / SYM cord-339015-qn8wbnlw 52 5 AIDS AIDS NNP cord-339015-qn8wbnlw 52 6 patients patient NNS cord-339015-qn8wbnlw 52 7 is be VBZ cord-339015-qn8wbnlw 52 8 often often RB cord-339015-qn8wbnlw 52 9 caused cause VBN cord-339015-qn8wbnlw 52 10 by by IN cord-339015-qn8wbnlw 52 11 protozoa protozoan NNS cord-339015-qn8wbnlw 52 12 Cryptosporidium cryptosporidium NN cord-339015-qn8wbnlw 52 13 parvum parvum NN cord-339015-qn8wbnlw 52 14 . . . cord-339015-qn8wbnlw 53 1 Immune immune JJ cord-339015-qn8wbnlw 53 2 reconstitution reconstitution NN cord-339015-qn8wbnlw 53 3 inflammatory inflammatory JJ cord-339015-qn8wbnlw 53 4 syndrome syndrome NN cord-339015-qn8wbnlw 53 5 , , , cord-339015-qn8wbnlw 53 6 a a DT cord-339015-qn8wbnlw 53 7 life life NN cord-339015-qn8wbnlw 53 8 - - HYPH cord-339015-qn8wbnlw 53 9 threatening threaten VBG cord-339015-qn8wbnlw 53 10 complication complication NN cord-339015-qn8wbnlw 53 11 of of IN cord-339015-qn8wbnlw 53 12 antiretroviral antiretroviral JJ cord-339015-qn8wbnlw 53 13 therapy therapy NN cord-339015-qn8wbnlw 53 14 , , , cord-339015-qn8wbnlw 53 15 may may MD cord-339015-qn8wbnlw 53 16 occur occur VB cord-339015-qn8wbnlw 53 17 , , , cord-339015-qn8wbnlw 53 18 leading lead VBG cord-339015-qn8wbnlw 53 19 to to IN cord-339015-qn8wbnlw 53 20 an an DT cord-339015-qn8wbnlw 53 21 exuberant exuberant JJ cord-339015-qn8wbnlw 53 22 inflammatory inflammatory JJ cord-339015-qn8wbnlw 53 23 response response NN cord-339015-qn8wbnlw 53 24 against against IN cord-339015-qn8wbnlw 53 25 a a DT cord-339015-qn8wbnlw 53 26 pathogen pathogen NN cord-339015-qn8wbnlw 53 27 that that WDT cord-339015-qn8wbnlw 53 28 may may MD cord-339015-qn8wbnlw 53 29 previously previously RB cord-339015-qn8wbnlw 53 30 been be VBN cord-339015-qn8wbnlw 53 31 latent latent JJ cord-339015-qn8wbnlw 53 32 . . . cord-339015-qn8wbnlw 54 1 Gram gram NN cord-339015-qn8wbnlw 54 2 - - HYPH cord-339015-qn8wbnlw 54 3 positive positive JJ cord-339015-qn8wbnlw 54 4 organisms organism NNS cord-339015-qn8wbnlw 54 5 are be VBP cord-339015-qn8wbnlw 54 6 on on IN cord-339015-qn8wbnlw 54 7 the the DT cord-339015-qn8wbnlw 54 8 rise rise NN cord-339015-qn8wbnlw 54 9 in in IN cord-339015-qn8wbnlw 54 10 neutropenia neutropenia NN cord-339015-qn8wbnlw 54 11 patients patient NNS cord-339015-qn8wbnlw 54 12 . . . cord-339015-qn8wbnlw 55 1 These these DT cord-339015-qn8wbnlw 55 2 include include VBP cord-339015-qn8wbnlw 55 3 Staphylococcus Staphylococcus NNP cord-339015-qn8wbnlw 55 4 , , , cord-339015-qn8wbnlw 55 5 Streptococcus Streptococcus NNP cord-339015-qn8wbnlw 55 6 , , , cord-339015-qn8wbnlw 55 7 Enterococcus Enterococcus NNP cord-339015-qn8wbnlw 55 8 , , , cord-339015-qn8wbnlw 55 9 and and CC cord-339015-qn8wbnlw 55 10 Corynebacterium Corynebacterium NNP cord-339015-qn8wbnlw 55 11 species specie NNS cord-339015-qn8wbnlw 55 12 . . . cord-339015-qn8wbnlw 56 1 Gram gram NN cord-339015-qn8wbnlw 56 2 - - HYPH cord-339015-qn8wbnlw 56 3 negative negative JJ cord-339015-qn8wbnlw 56 4 bacilli bacilli NN cord-339015-qn8wbnlw 56 5 include include VBP cord-339015-qn8wbnlw 56 6 Pseudomonas Pseudomonas NNP cord-339015-qn8wbnlw 56 7 , , , cord-339015-qn8wbnlw 56 8 Escherichia Escherichia NNP cord-339015-qn8wbnlw 56 9 , , , cord-339015-qn8wbnlw 56 10 and and CC cord-339015-qn8wbnlw 56 11 Klebsiella Klebsiella NNP cord-339015-qn8wbnlw 56 12 species specie NNS cord-339015-qn8wbnlw 56 13 . . . cord-339015-qn8wbnlw 57 1 Empiric empiric NN cord-339015-qn8wbnlw 57 2 therapy therapy NN cord-339015-qn8wbnlw 57 3 covering cover VBG cord-339015-qn8wbnlw 57 4 both both CC cord-339015-qn8wbnlw 57 5 gram gram NN cord-339015-qn8wbnlw 57 6 - - HYPH cord-339015-qn8wbnlw 57 7 negative negative JJ cord-339015-qn8wbnlw 57 8 and and CC cord-339015-qn8wbnlw 57 9 gram gram NN cord-339015-qn8wbnlw 57 10 - - HYPH cord-339015-qn8wbnlw 57 11 positive positive JJ cord-339015-qn8wbnlw 57 12 organisms organism NNS cord-339015-qn8wbnlw 57 13 is be VBZ cord-339015-qn8wbnlw 57 14 recommended recommend VBN cord-339015-qn8wbnlw 57 15 for for IN cord-339015-qn8wbnlw 57 16 febrile febrile JJ cord-339015-qn8wbnlw 57 17 neutropenic neutropenic JJ cord-339015-qn8wbnlw 57 18 patients patient NNS cord-339015-qn8wbnlw 57 19 Patients patient NNS cord-339015-qn8wbnlw 57 20 who who WP cord-339015-qn8wbnlw 57 21 have have VBP cord-339015-qn8wbnlw 57 22 undergone undergo VBN cord-339015-qn8wbnlw 57 23 solid solid JJ cord-339015-qn8wbnlw 57 24 organ organ NN cord-339015-qn8wbnlw 57 25 transplantation transplantation NN cord-339015-qn8wbnlw 57 26 present present JJ cord-339015-qn8wbnlw 57 27 with with IN cord-339015-qn8wbnlw 57 28 a a DT cord-339015-qn8wbnlw 57 29 broad broad JJ cord-339015-qn8wbnlw 57 30 spectrum spectrum NN cord-339015-qn8wbnlw 57 31 of of IN cord-339015-qn8wbnlw 57 32 infections infection NNS cord-339015-qn8wbnlw 57 33 overtime overtime NN cord-339015-qn8wbnlw 57 34 . . . cord-339015-qn8wbnlw 58 1 7 7 CD cord-339015-qn8wbnlw 59 1 During during IN cord-339015-qn8wbnlw 59 2 the the DT cord-339015-qn8wbnlw 59 3 postoperative postoperative JJ cord-339015-qn8wbnlw 59 4 period period NN cord-339015-qn8wbnlw 59 5 , , , cord-339015-qn8wbnlw 59 6 the the DT cord-339015-qn8wbnlw 59 7 common common JJ cord-339015-qn8wbnlw 59 8 infections infection NNS cord-339015-qn8wbnlw 59 9 include include VBP cord-339015-qn8wbnlw 59 10 health health NN cord-339015-qn8wbnlw 59 11 care care NN cord-339015-qn8wbnlw 59 12 - - HYPH cord-339015-qn8wbnlw 59 13 associated associate VBN cord-339015-qn8wbnlw 59 14 pneumonia pneumonia NN cord-339015-qn8wbnlw 59 15 , , , cord-339015-qn8wbnlw 59 16 urinary urinary JJ cord-339015-qn8wbnlw 59 17 tract tract JJ cord-339015-qn8wbnlw 59 18 infections infection NNS cord-339015-qn8wbnlw 59 19 , , , cord-339015-qn8wbnlw 59 20 and and CC cord-339015-qn8wbnlw 59 21 catheter catheter NN cord-339015-qn8wbnlw 59 22 - - HYPH cord-339015-qn8wbnlw 59 23 associated associate VBN cord-339015-qn8wbnlw 59 24 and and CC cord-339015-qn8wbnlw 59 25 device device NN cord-339015-qn8wbnlw 59 26 - - HYPH cord-339015-qn8wbnlw 59 27 associated associate VBN cord-339015-qn8wbnlw 59 28 infections infection NNS cord-339015-qn8wbnlw 59 29 . . . cord-339015-qn8wbnlw 60 1 The the DT cord-339015-qn8wbnlw 60 2 risk risk NN cord-339015-qn8wbnlw 60 3 of of IN cord-339015-qn8wbnlw 60 4 opportunistic opportunistic JJ cord-339015-qn8wbnlw 60 5 infections infection NNS cord-339015-qn8wbnlw 60 6 increases increase VBZ cord-339015-qn8wbnlw 60 7 over over IN cord-339015-qn8wbnlw 60 8 time time NN cord-339015-qn8wbnlw 60 9 due due JJ cord-339015-qn8wbnlw 60 10 to to IN cord-339015-qn8wbnlw 60 11 immunosuppressive immunosuppressive JJ cord-339015-qn8wbnlw 60 12 therapy therapy NN cord-339015-qn8wbnlw 60 13 to to TO cord-339015-qn8wbnlw 60 14 prevent prevent VB cord-339015-qn8wbnlw 60 15 organ organ NN cord-339015-qn8wbnlw 60 16 rejection rejection NN cord-339015-qn8wbnlw 60 17 . . . cord-339015-qn8wbnlw 60 18 _SP cord-339015-qn8wbnlw 61 1 Viruses virus NNS cord-339015-qn8wbnlw 61 2 are be VBP cord-339015-qn8wbnlw 61 3 increasingly increasingly RB cord-339015-qn8wbnlw 61 4 being be VBG cord-339015-qn8wbnlw 61 5 recognized recognize VBN cord-339015-qn8wbnlw 61 6 as as IN cord-339015-qn8wbnlw 61 7 a a DT cord-339015-qn8wbnlw 61 8 major major JJ cord-339015-qn8wbnlw 61 9 cause cause NN cord-339015-qn8wbnlw 61 10 of of IN cord-339015-qn8wbnlw 61 11 morbidity morbidity NN cord-339015-qn8wbnlw 61 12 in in IN cord-339015-qn8wbnlw 61 13 the the DT cord-339015-qn8wbnlw 61 14 ICU ICU NNP cord-339015-qn8wbnlw 61 15 . . . cord-339015-qn8wbnlw 62 1 Table table NN cord-339015-qn8wbnlw 62 2 1 1 CD cord-339015-qn8wbnlw 62 3 shows show VBZ cord-339015-qn8wbnlw 62 4 the the DT cord-339015-qn8wbnlw 62 5 commonly commonly RB cord-339015-qn8wbnlw 62 6 encountered encounter VBN cord-339015-qn8wbnlw 62 7 species specie NNS cord-339015-qn8wbnlw 62 8 and and CC cord-339015-qn8wbnlw 62 9 their -PRON- PRP$ cord-339015-qn8wbnlw 62 10 clinical clinical JJ cord-339015-qn8wbnlw 62 11 features feature NNS cord-339015-qn8wbnlw 62 12 , , , cord-339015-qn8wbnlw 62 13 workup workup NN cord-339015-qn8wbnlw 62 14 , , , cord-339015-qn8wbnlw 62 15 management management NN cord-339015-qn8wbnlw 62 16 , , , cord-339015-qn8wbnlw 62 17 and and CC cord-339015-qn8wbnlw 62 18 prevention prevention NN cord-339015-qn8wbnlw 62 19 . . . cord-339015-qn8wbnlw 63 1 In in IN cord-339015-qn8wbnlw 63 2 the the DT cord-339015-qn8wbnlw 63 3 ICU ICU NNP cord-339015-qn8wbnlw 63 4 , , , cord-339015-qn8wbnlw 63 5 viral viral JJ cord-339015-qn8wbnlw 63 6 illness illness NN cord-339015-qn8wbnlw 63 7 can can MD cord-339015-qn8wbnlw 63 8 be be VB cord-339015-qn8wbnlw 63 9 community community NN cord-339015-qn8wbnlw 63 10 acquired acquire VBN cord-339015-qn8wbnlw 63 11 or or CC cord-339015-qn8wbnlw 63 12 nosocomial nosocomial JJ cord-339015-qn8wbnlw 63 13 . . . cord-339015-qn8wbnlw 64 1 Viruses virus NNS cord-339015-qn8wbnlw 64 2 can can MD cord-339015-qn8wbnlw 64 3 lead lead VB cord-339015-qn8wbnlw 64 4 to to IN cord-339015-qn8wbnlw 64 5 multiple multiple JJ cord-339015-qn8wbnlw 64 6 organ organ NN cord-339015-qn8wbnlw 64 7 system system NN cord-339015-qn8wbnlw 64 8 complications complication NNS cord-339015-qn8wbnlw 64 9 . . . cord-339015-qn8wbnlw 65 1 The the DT cord-339015-qn8wbnlw 65 2 most most RBS cord-339015-qn8wbnlw 65 3 commonly commonly RB cord-339015-qn8wbnlw 65 4 affected affect VBN cord-339015-qn8wbnlw 65 5 systems system NNS cord-339015-qn8wbnlw 65 6 are be VBP cord-339015-qn8wbnlw 65 7 the the DT cord-339015-qn8wbnlw 65 8 respiratory respiratory NN cord-339015-qn8wbnlw 65 9 , , , cord-339015-qn8wbnlw 65 10 GI GI NNP cord-339015-qn8wbnlw 65 11 , , , cord-339015-qn8wbnlw 65 12 neurologic neurologic JJ cord-339015-qn8wbnlw 65 13 systems system NNS cord-339015-qn8wbnlw 65 14 , , , cord-339015-qn8wbnlw 65 15 skin skin NN cord-339015-qn8wbnlw 65 16 , , , cord-339015-qn8wbnlw 65 17 and and CC cord-339015-qn8wbnlw 65 18 mucous mucous JJ cord-339015-qn8wbnlw 65 19 membranes membrane NNS cord-339015-qn8wbnlw 65 20 , , , cord-339015-qn8wbnlw 65 21 which which WDT cord-339015-qn8wbnlw 65 22 all all DT cord-339015-qn8wbnlw 65 23 eventually eventually RB cord-339015-qn8wbnlw 65 24 may may MD cord-339015-qn8wbnlw 65 25 lead lead VB cord-339015-qn8wbnlw 65 26 to to IN cord-339015-qn8wbnlw 65 27 sepsis sepsis NN cord-339015-qn8wbnlw 65 28 . . . cord-339015-qn8wbnlw 66 1 Viral viral JJ cord-339015-qn8wbnlw 66 2 infections infection NNS cord-339015-qn8wbnlw 66 3 are be VBP cord-339015-qn8wbnlw 66 4 also also RB cord-339015-qn8wbnlw 66 5 a a DT cord-339015-qn8wbnlw 66 6 major major JJ cord-339015-qn8wbnlw 66 7 source source NN cord-339015-qn8wbnlw 66 8 of of IN cord-339015-qn8wbnlw 66 9 morbidity morbidity NN cord-339015-qn8wbnlw 66 10 in in IN cord-339015-qn8wbnlw 66 11 the the DT cord-339015-qn8wbnlw 66 12 neonatal neonatal JJ cord-339015-qn8wbnlw 66 13 ICUs icus NN cord-339015-qn8wbnlw 66 14 ( ( -LRB- cord-339015-qn8wbnlw 66 15 Box Box NNP cord-339015-qn8wbnlw 66 16 3 3 CD cord-339015-qn8wbnlw 66 17 ) ) -RRB- cord-339015-qn8wbnlw 66 18 and and CC cord-339015-qn8wbnlw 66 19 are be VBP cord-339015-qn8wbnlw 66 20 also also RB cord-339015-qn8wbnlw 66 21 a a DT cord-339015-qn8wbnlw 66 22 leading leading JJ cord-339015-qn8wbnlw 66 23 cause cause NN cord-339015-qn8wbnlw 66 24 of of IN cord-339015-qn8wbnlw 66 25 central central JJ cord-339015-qn8wbnlw 66 26 nervous nervous JJ cord-339015-qn8wbnlw 66 27 system system NN cord-339015-qn8wbnlw 66 28 infections infection NNS cord-339015-qn8wbnlw 66 29 ( ( -LRB- cord-339015-qn8wbnlw 66 30 Box Box NNP cord-339015-qn8wbnlw 66 31 4 4 CD cord-339015-qn8wbnlw 66 32 ) ) -RRB- cord-339015-qn8wbnlw 66 33 . . . cord-339015-qn8wbnlw 67 1 Prompt prompt JJ cord-339015-qn8wbnlw 67 2 diagnosis diagnosis NN cord-339015-qn8wbnlw 67 3 and and CC cord-339015-qn8wbnlw 67 4 antiviral antiviral JJ cord-339015-qn8wbnlw 67 5 therapy therapy NN cord-339015-qn8wbnlw 67 6 are be VBP cord-339015-qn8wbnlw 67 7 key key JJ cord-339015-qn8wbnlw 67 8 to to IN cord-339015-qn8wbnlw 67 9 good good JJ cord-339015-qn8wbnlw 67 10 outcomes outcome NNS cord-339015-qn8wbnlw 67 11 . . . cord-339015-qn8wbnlw 68 1 For for IN cord-339015-qn8wbnlw 68 2 long long JJ cord-339015-qn8wbnlw 68 3 - - HYPH cord-339015-qn8wbnlw 68 4 term term NN cord-339015-qn8wbnlw 68 5 and and CC cord-339015-qn8wbnlw 68 6 population population NN cord-339015-qn8wbnlw 68 7 - - HYPH cord-339015-qn8wbnlw 68 8 wide wide JJ cord-339015-qn8wbnlw 68 9 prevention prevention NN cord-339015-qn8wbnlw 68 10 , , , cord-339015-qn8wbnlw 68 11 immunization immunization NN cord-339015-qn8wbnlw 68 12 , , , cord-339015-qn8wbnlw 68 13 prophylaxis prophylaxis NN cord-339015-qn8wbnlw 68 14 , , , cord-339015-qn8wbnlw 68 15 and and CC cord-339015-qn8wbnlw 68 16 infection infection NN cord-339015-qn8wbnlw 68 17 control control NN cord-339015-qn8wbnlw 68 18 should should MD cord-339015-qn8wbnlw 68 19 routinely routinely RB cord-339015-qn8wbnlw 68 20 be be VB cord-339015-qn8wbnlw 68 21 encouraged encourage VBN cord-339015-qn8wbnlw 68 22 . . . cord-339015-qn8wbnlw 69 1 Viral viral JJ cord-339015-qn8wbnlw 69 2 community community NN cord-339015-qn8wbnlw 69 3 - - HYPH cord-339015-qn8wbnlw 69 4 acquired acquire VBN cord-339015-qn8wbnlw 69 5 pneumonia pneumonia NN cord-339015-qn8wbnlw 69 6 is be VBZ cord-339015-qn8wbnlw 69 7 frequently frequently RB cord-339015-qn8wbnlw 69 8 caused cause VBN cord-339015-qn8wbnlw 69 9 by by IN cord-339015-qn8wbnlw 69 10 influenza influenza NN cord-339015-qn8wbnlw 69 11 followed follow VBN cord-339015-qn8wbnlw 69 12 by by IN cord-339015-qn8wbnlw 69 13 other other JJ cord-339015-qn8wbnlw 69 14 respiratory respiratory JJ cord-339015-qn8wbnlw 69 15 viruses virus NNS cord-339015-qn8wbnlw 69 16 , , , cord-339015-qn8wbnlw 69 17 such such JJ cord-339015-qn8wbnlw 69 18 as as IN cord-339015-qn8wbnlw 69 19 parainfluenza parainfluenza NNP cord-339015-qn8wbnlw 69 20 , , , cord-339015-qn8wbnlw 69 21 rhinovirus rhinovirus NN cord-339015-qn8wbnlw 69 22 , , , cord-339015-qn8wbnlw 69 23 adenovirus adenovirus NN cord-339015-qn8wbnlw 69 24 , , , cord-339015-qn8wbnlw 69 25 RSV RSV NNP cord-339015-qn8wbnlw 69 26 , , , cord-339015-qn8wbnlw 69 27 and and CC cord-339015-qn8wbnlw 69 28 coronaviruses coronaviruse NNS cord-339015-qn8wbnlw 69 29 . . . cord-339015-qn8wbnlw 70 1 The the DT cord-339015-qn8wbnlw 70 2 symptoms symptom NNS cord-339015-qn8wbnlw 70 3 of of IN cord-339015-qn8wbnlw 70 4 viral viral JJ cord-339015-qn8wbnlw 70 5 pneumonia pneumonia NN cord-339015-qn8wbnlw 70 6 may may MD cord-339015-qn8wbnlw 70 7 vary vary VB cord-339015-qn8wbnlw 70 8 from from IN cord-339015-qn8wbnlw 70 9 fever fever NN cord-339015-qn8wbnlw 70 10 to to IN cord-339015-qn8wbnlw 70 11 myalgia myalgia NN cord-339015-qn8wbnlw 70 12 to to IN cord-339015-qn8wbnlw 70 13 arthralgia arthralgia NNP cord-339015-qn8wbnlw 70 14 headache headache NN cord-339015-qn8wbnlw 70 15 to to IN cord-339015-qn8wbnlw 70 16 shortness shortness NN cord-339015-qn8wbnlw 70 17 of of IN cord-339015-qn8wbnlw 70 18 breath breath NN cord-339015-qn8wbnlw 70 19 to to TO cord-339015-qn8wbnlw 70 20 cough cough VB cord-339015-qn8wbnlw 70 21 and and CC cord-339015-qn8wbnlw 70 22 to to TO cord-339015-qn8wbnlw 70 23 acute acute JJ cord-339015-qn8wbnlw 70 24 respiratory respiratory JJ cord-339015-qn8wbnlw 70 25 distress distress NN cord-339015-qn8wbnlw 70 26 syndrome syndrome NN cord-339015-qn8wbnlw 70 27 . . . cord-339015-qn8wbnlw 71 1 APPs app NNS cord-339015-qn8wbnlw 71 2 working work VBG cord-339015-qn8wbnlw 71 3 in in IN cord-339015-qn8wbnlw 71 4 the the DT cord-339015-qn8wbnlw 71 5 ICU ICU NNP cord-339015-qn8wbnlw 71 6 need need VBP cord-339015-qn8wbnlw 71 7 to to TO cord-339015-qn8wbnlw 71 8 recognize recognize VB cord-339015-qn8wbnlw 71 9 viral viral JJ cord-339015-qn8wbnlw 71 10 community community NN cord-339015-qn8wbnlw 71 11 - - HYPH cord-339015-qn8wbnlw 71 12 acquired acquire VBN cord-339015-qn8wbnlw 71 13 pneumonia pneumonia NN cord-339015-qn8wbnlw 71 14 early early RB cord-339015-qn8wbnlw 71 15 and and CC cord-339015-qn8wbnlw 71 16 manage manage VB cord-339015-qn8wbnlw 71 17 it -PRON- PRP cord-339015-qn8wbnlw 71 18 aggressively aggressively RB cord-339015-qn8wbnlw 71 19 to to TO cord-339015-qn8wbnlw 71 20 prevent prevent VB cord-339015-qn8wbnlw 71 21 complications complication NNS cord-339015-qn8wbnlw 71 22 and and CC cord-339015-qn8wbnlw 71 23 improve improve VB cord-339015-qn8wbnlw 71 24 outcomes outcome NNS cord-339015-qn8wbnlw 71 25 . . . cord-339015-qn8wbnlw 72 1 The the DT cord-339015-qn8wbnlw 72 2 diagnosis diagnosis NN cord-339015-qn8wbnlw 72 3 can can MD cord-339015-qn8wbnlw 72 4 be be VB cord-339015-qn8wbnlw 72 5 made make VBN cord-339015-qn8wbnlw 72 6 clinically clinically RB cord-339015-qn8wbnlw 72 7 and and CC cord-339015-qn8wbnlw 72 8 then then RB cord-339015-qn8wbnlw 72 9 confirmed confirm VBN cord-339015-qn8wbnlw 72 10 by by IN cord-339015-qn8wbnlw 72 11 serology serology NN cord-339015-qn8wbnlw 72 12 , , , cord-339015-qn8wbnlw 72 13 polymerase polymerase NN cord-339015-qn8wbnlw 72 14 chain chain NN cord-339015-qn8wbnlw 72 15 reaction reaction NN cord-339015-qn8wbnlw 72 16 ( ( -LRB- cord-339015-qn8wbnlw 72 17 PCR PCR NNP cord-339015-qn8wbnlw 72 18 ) ) -RRB- cord-339015-qn8wbnlw 72 19 , , , cord-339015-qn8wbnlw 72 20 or or CC cord-339015-qn8wbnlw 72 21 culture culture NN cord-339015-qn8wbnlw 72 22 . . . cord-339015-qn8wbnlw 73 1 Treatment treatment NN cord-339015-qn8wbnlw 73 2 is be VBZ cord-339015-qn8wbnlw 73 3 mostly mostly RB cord-339015-qn8wbnlw 73 4 supportive supportive JJ cord-339015-qn8wbnlw 73 5 . . . cord-339015-qn8wbnlw 74 1 If if IN cord-339015-qn8wbnlw 74 2 the the DT cord-339015-qn8wbnlw 74 3 causative causative JJ cord-339015-qn8wbnlw 74 4 agent agent NN cord-339015-qn8wbnlw 74 5 is be VBZ cord-339015-qn8wbnlw 74 6 influenza influenza NN cord-339015-qn8wbnlw 74 7 , , , cord-339015-qn8wbnlw 74 8 oseltamivir oseltamivir FW cord-339015-qn8wbnlw 74 9 therapy therapy NN cord-339015-qn8wbnlw 74 10 is be VBZ cord-339015-qn8wbnlw 74 11 recommended recommend VBN cord-339015-qn8wbnlw 74 12 for for IN cord-339015-qn8wbnlw 74 13 adult adult NN cord-339015-qn8wbnlw 74 14 patients patient NNS cord-339015-qn8wbnlw 74 15 . . . cord-339015-qn8wbnlw 75 1 It -PRON- PRP cord-339015-qn8wbnlw 75 2 can can MD cord-339015-qn8wbnlw 75 3 shorten shorten VB cord-339015-qn8wbnlw 75 4 the the DT cord-339015-qn8wbnlw 75 5 duration duration NN cord-339015-qn8wbnlw 75 6 of of IN cord-339015-qn8wbnlw 75 7 symptoms symptom NNS cord-339015-qn8wbnlw 75 8 and and CC cord-339015-qn8wbnlw 75 9 improve improve VB cord-339015-qn8wbnlw 75 10 outcomes outcome NNS cord-339015-qn8wbnlw 75 11 in in IN cord-339015-qn8wbnlw 75 12 severe severe JJ cord-339015-qn8wbnlw 75 13 cases case NNS cord-339015-qn8wbnlw 75 14 . . . cord-339015-qn8wbnlw 76 1 Vaccination vaccination NN cord-339015-qn8wbnlw 76 2 is be VBZ cord-339015-qn8wbnlw 76 3 the the DT cord-339015-qn8wbnlw 76 4 best good JJS cord-339015-qn8wbnlw 76 5 preventative preventative JJ cord-339015-qn8wbnlw 76 6 measure measure NN cord-339015-qn8wbnlw 76 7 for for IN cord-339015-qn8wbnlw 76 8 these these DT cord-339015-qn8wbnlw 76 9 viruses virus NNS cord-339015-qn8wbnlw 76 10 . . . cord-339015-qn8wbnlw 77 1 Nosocomial nosocomial JJ cord-339015-qn8wbnlw 77 2 viral viral JJ cord-339015-qn8wbnlw 77 3 pneumonia pneumonia NN cord-339015-qn8wbnlw 77 4 in in IN cord-339015-qn8wbnlw 77 5 the the DT cord-339015-qn8wbnlw 77 6 ICU ICU NNP cord-339015-qn8wbnlw 77 7 is be VBZ cord-339015-qn8wbnlw 77 8 frequently frequently RB cord-339015-qn8wbnlw 77 9 caused cause VBN cord-339015-qn8wbnlw 77 10 by by IN cord-339015-qn8wbnlw 77 11 Herpesviridae Herpesviridae NNP cord-339015-qn8wbnlw 77 12 family family NN cord-339015-qn8wbnlw 77 13 of of IN cord-339015-qn8wbnlw 77 14 viruses virus NNS cord-339015-qn8wbnlw 77 15 , , , cord-339015-qn8wbnlw 77 16 which which WDT cord-339015-qn8wbnlw 77 17 include include VBP cord-339015-qn8wbnlw 77 18 HSV HSV NNP cord-339015-qn8wbnlw 77 19 and and CC cord-339015-qn8wbnlw 77 20 cytomegalovirus cytomegalovirus NNP cord-339015-qn8wbnlw 77 21 ( ( -LRB- cord-339015-qn8wbnlw 77 22 CMV CMV NNP cord-339015-qn8wbnlw 77 23 ) ) -RRB- cord-339015-qn8wbnlw 77 24 . . . cord-339015-qn8wbnlw 78 1 Immunocompromised immunocompromise VBN cord-339015-qn8wbnlw 78 2 patients patient NNS cord-339015-qn8wbnlw 78 3 are be VBP cord-339015-qn8wbnlw 78 4 particularly particularly RB cord-339015-qn8wbnlw 78 5 at at IN cord-339015-qn8wbnlw 78 6 high high JJ cord-339015-qn8wbnlw 78 7 risk risk NN cord-339015-qn8wbnlw 78 8 ( ( -LRB- cord-339015-qn8wbnlw 78 9 see see VB cord-339015-qn8wbnlw 78 10 Box Box NNP cord-339015-qn8wbnlw 78 11 2 2 CD cord-339015-qn8wbnlw 78 12 ) ) -RRB- cord-339015-qn8wbnlw 78 13 . . . cord-339015-qn8wbnlw 79 1 HSV HSV NNP cord-339015-qn8wbnlw 79 2 can can MD cord-339015-qn8wbnlw 79 3 be be VB cord-339015-qn8wbnlw 79 4 detected detect VBN cord-339015-qn8wbnlw 79 5 in in IN cord-339015-qn8wbnlw 79 6 the the DT cord-339015-qn8wbnlw 79 7 throat throat NN cord-339015-qn8wbnlw 79 8 and and CC cord-339015-qn8wbnlw 79 9 The the DT cord-339015-qn8wbnlw 79 10 most most RBS cord-339015-qn8wbnlw 79 11 common common JJ cord-339015-qn8wbnlw 79 12 nosocomial nosocomial JJ cord-339015-qn8wbnlw 79 13 bacterial bacterial JJ cord-339015-qn8wbnlw 79 14 species specie NNS cord-339015-qn8wbnlw 79 15 among among IN cord-339015-qn8wbnlw 79 16 neonates neonate NNS cord-339015-qn8wbnlw 79 17 are be VBP cord-339015-qn8wbnlw 79 18 Staphylococcus Staphylococcus NNP cord-339015-qn8wbnlw 79 19 , , , cord-339015-qn8wbnlw 79 20 Enterococci Enterococci NNP cord-339015-qn8wbnlw 79 21 , , , cord-339015-qn8wbnlw 79 22 Enterobacter Enterobacter NNP cord-339015-qn8wbnlw 79 23 , , , cord-339015-qn8wbnlw 79 24 E e NN cord-339015-qn8wbnlw 79 25 coli coli NNS cord-339015-qn8wbnlw 79 26 , , , cord-339015-qn8wbnlw 79 27 and and CC cord-339015-qn8wbnlw 79 28 group group NN cord-339015-qn8wbnlw 79 29 B b NN cord-339015-qn8wbnlw 79 30 streptococcus streptococcus NN cord-339015-qn8wbnlw 79 31 . . . cord-339015-qn8wbnlw 80 1 The the DT cord-339015-qn8wbnlw 80 2 bloodstream bloodstream NN cord-339015-qn8wbnlw 80 3 is be VBZ cord-339015-qn8wbnlw 80 4 among among IN cord-339015-qn8wbnlw 80 5 the the DT cord-339015-qn8wbnlw 80 6 most most RBS cord-339015-qn8wbnlw 80 7 frequent frequent JJ cord-339015-qn8wbnlw 80 8 site site NN cord-339015-qn8wbnlw 80 9 of of IN cord-339015-qn8wbnlw 80 10 nosocomial nosocomial JJ cord-339015-qn8wbnlw 80 11 infection infection NN cord-339015-qn8wbnlw 80 12 followed follow VBN cord-339015-qn8wbnlw 80 13 by by IN cord-339015-qn8wbnlw 80 14 nosocomial nosocomial JJ cord-339015-qn8wbnlw 80 15 pneumonia pneumonia NN cord-339015-qn8wbnlw 80 16 ; ; : cord-339015-qn8wbnlw 80 17 GI GI NNP cord-339015-qn8wbnlw 80 18 ; ; : cord-339015-qn8wbnlw 80 19 and and CC cord-339015-qn8wbnlw 80 20 eye eye NN cord-339015-qn8wbnlw 80 21 , , , cord-339015-qn8wbnlw 80 22 ear ear NN cord-339015-qn8wbnlw 80 23 , , , cord-339015-qn8wbnlw 80 24 nose nose NN cord-339015-qn8wbnlw 80 25 , , , cord-339015-qn8wbnlw 80 26 and and CC cord-339015-qn8wbnlw 80 27 throat throat NN cord-339015-qn8wbnlw 80 28 sites site NNS cord-339015-qn8wbnlw 80 29 . . . cord-339015-qn8wbnlw 81 1 8 8 CD cord-339015-qn8wbnlw 82 1 The the DT cord-339015-qn8wbnlw 82 2 major major JJ cord-339015-qn8wbnlw 82 3 risk risk NN cord-339015-qn8wbnlw 82 4 factors factor NNS cord-339015-qn8wbnlw 82 5 are be VBP cord-339015-qn8wbnlw 82 6 poor poor JJ cord-339015-qn8wbnlw 82 7 umbilical umbilical JJ cord-339015-qn8wbnlw 82 8 handling handling NN cord-339015-qn8wbnlw 82 9 and and CC cord-339015-qn8wbnlw 82 10 central central JJ cord-339015-qn8wbnlw 82 11 intravenous intravenous JJ cord-339015-qn8wbnlw 82 12 catheter catheter NN cord-339015-qn8wbnlw 82 13 use use NN cord-339015-qn8wbnlw 82 14 . . . cord-339015-qn8wbnlw 83 1 Outbreaks outbreak NNS cord-339015-qn8wbnlw 83 2 of of IN cord-339015-qn8wbnlw 83 3 viral viral JJ cord-339015-qn8wbnlw 83 4 infections infection NNS cord-339015-qn8wbnlw 83 5 in in IN cord-339015-qn8wbnlw 83 6 the the DT cord-339015-qn8wbnlw 83 7 neonatal neonatal JJ cord-339015-qn8wbnlw 83 8 ICUs icu NNS cord-339015-qn8wbnlw 83 9 are be VBP cord-339015-qn8wbnlw 83 10 commonly commonly RB cord-339015-qn8wbnlw 83 11 caused cause VBN cord-339015-qn8wbnlw 83 12 by by IN cord-339015-qn8wbnlw 83 13 rotavirus rotavirus NN cord-339015-qn8wbnlw 83 14 , , , cord-339015-qn8wbnlw 83 15 RSV RSV NNP cord-339015-qn8wbnlw 83 16 , , , cord-339015-qn8wbnlw 83 17 enterovirus enterovirus NN cord-339015-qn8wbnlw 83 18 , , , cord-339015-qn8wbnlw 83 19 hepatitis hepatitis NNP cord-339015-qn8wbnlw 83 20 A a DT cord-339015-qn8wbnlw 83 21 virus virus NN cord-339015-qn8wbnlw 83 22 , , , cord-339015-qn8wbnlw 83 23 and and CC cord-339015-qn8wbnlw 83 24 adenovirus adenovirus NN cord-339015-qn8wbnlw 83 25 . . . cord-339015-qn8wbnlw 84 1 Nosocomial nosocomial JJ cord-339015-qn8wbnlw 84 2 infections infection NNS cord-339015-qn8wbnlw 84 3 can can MD cord-339015-qn8wbnlw 84 4 be be VB cord-339015-qn8wbnlw 84 5 transmitted transmit VBN cord-339015-qn8wbnlw 84 6 via via IN cord-339015-qn8wbnlw 84 7 droplet droplet NN cord-339015-qn8wbnlw 84 8 spread spread NN cord-339015-qn8wbnlw 84 9 , , , cord-339015-qn8wbnlw 84 10 hands hand NNS cord-339015-qn8wbnlw 84 11 of of IN cord-339015-qn8wbnlw 84 12 infected infected JJ cord-339015-qn8wbnlw 84 13 hospital hospital NN cord-339015-qn8wbnlw 84 14 personnel personnel NNS cord-339015-qn8wbnlw 84 15 and and CC cord-339015-qn8wbnlw 84 16 other other JJ cord-339015-qn8wbnlw 84 17 individuals individual NNS cord-339015-qn8wbnlw 84 18 , , , cord-339015-qn8wbnlw 84 19 contaminated contaminated JJ cord-339015-qn8wbnlw 84 20 medical medical JJ cord-339015-qn8wbnlw 84 21 equipment equipment NN cord-339015-qn8wbnlw 84 22 , , , cord-339015-qn8wbnlw 84 23 and and CC cord-339015-qn8wbnlw 84 24 breast breast NN cord-339015-qn8wbnlw 84 25 milk milk NN cord-339015-qn8wbnlw 84 26 from from IN cord-339015-qn8wbnlw 84 27 infected infected JJ cord-339015-qn8wbnlw 84 28 mothers mother NNS cord-339015-qn8wbnlw 84 29 . . . cord-339015-qn8wbnlw 85 1 Other other JJ cord-339015-qn8wbnlw 85 2 pathogens pathogen NNS cord-339015-qn8wbnlw 85 3 , , , cord-339015-qn8wbnlw 85 4 such such JJ cord-339015-qn8wbnlw 85 5 as as IN cord-339015-qn8wbnlw 85 6 HIV HIV NNP cord-339015-qn8wbnlw 85 7 , , , cord-339015-qn8wbnlw 85 8 hepatitis hepatitis NNP cord-339015-qn8wbnlw 85 9 B B NNP cord-339015-qn8wbnlw 85 10 / / SYM cord-339015-qn8wbnlw 85 11 C C NNP cord-339015-qn8wbnlw 85 12 , , , cord-339015-qn8wbnlw 85 13 HSV HSV NNP cord-339015-qn8wbnlw 85 14 , , , cord-339015-qn8wbnlw 85 15 VZV VZV NNP cord-339015-qn8wbnlw 85 16 , , , cord-339015-qn8wbnlw 85 17 and and CC cord-339015-qn8wbnlw 85 18 CMV CMV NNP cord-339015-qn8wbnlw 85 19 , , , cord-339015-qn8wbnlw 85 20 can can MD cord-339015-qn8wbnlw 85 21 be be VB cord-339015-qn8wbnlw 85 22 transmitted transmit VBN cord-339015-qn8wbnlw 85 23 vertically vertically RB cord-339015-qn8wbnlw 85 24 from from IN cord-339015-qn8wbnlw 85 25 infected infected JJ cord-339015-qn8wbnlw 85 26 mothers mother NNS cord-339015-qn8wbnlw 85 27 . . . cord-339015-qn8wbnlw 86 1 The the DT cord-339015-qn8wbnlw 86 2 clinical clinical JJ cord-339015-qn8wbnlw 86 3 manifestations manifestation NNS cord-339015-qn8wbnlw 86 4 can can MD cord-339015-qn8wbnlw 86 5 be be VB cord-339015-qn8wbnlw 86 6 severe severe JJ cord-339015-qn8wbnlw 86 7 requiring require VBG cord-339015-qn8wbnlw 86 8 mechanical mechanical JJ cord-339015-qn8wbnlw 86 9 ventilation ventilation NN cord-339015-qn8wbnlw 86 10 . . . cord-339015-qn8wbnlw 87 1 Complications complication NNS cord-339015-qn8wbnlw 87 2 associated associate VBN cord-339015-qn8wbnlw 87 3 with with IN cord-339015-qn8wbnlw 87 4 nosocomial nosocomial JJ cord-339015-qn8wbnlw 87 5 viral viral JJ cord-339015-qn8wbnlw 87 6 infections infection NNS cord-339015-qn8wbnlw 87 7 can can MD cord-339015-qn8wbnlw 87 8 be be VB cord-339015-qn8wbnlw 87 9 grouped group VBN cord-339015-qn8wbnlw 87 10 into into IN cord-339015-qn8wbnlw 87 11 1 1 CD cord-339015-qn8wbnlw 87 12 . . . cord-339015-qn8wbnlw 88 1 Respiratory respiratory JJ cord-339015-qn8wbnlw 88 2 complications complication NNS cord-339015-qn8wbnlw 88 3 , , , cord-339015-qn8wbnlw 88 4 such such JJ cord-339015-qn8wbnlw 88 5 as as IN cord-339015-qn8wbnlw 88 6 RSV RSV NNP cord-339015-qn8wbnlw 88 7 , , , cord-339015-qn8wbnlw 88 8 influenza influenza NN cord-339015-qn8wbnlw 88 9 , , , cord-339015-qn8wbnlw 88 10 parainfluenza parainfluenza NNP cord-339015-qn8wbnlw 88 11 , , , cord-339015-qn8wbnlw 88 12 adenoviruses adenovirus NNS cord-339015-qn8wbnlw 88 13 , , , cord-339015-qn8wbnlw 88 14 and and CC cord-339015-qn8wbnlw 88 15 coronaviruses coronaviruse NNS cord-339015-qn8wbnlw 88 16 2 2 CD cord-339015-qn8wbnlw 88 17 . . . cord-339015-qn8wbnlw 89 1 GI GI NNP cord-339015-qn8wbnlw 89 2 complications complication NNS cord-339015-qn8wbnlw 89 3 , , , cord-339015-qn8wbnlw 89 4 such such JJ cord-339015-qn8wbnlw 89 5 as as IN cord-339015-qn8wbnlw 89 6 rotavirus rotavirus NN cord-339015-qn8wbnlw 89 7 ( ( -LRB- cord-339015-qn8wbnlw 89 8 the the DT cord-339015-qn8wbnlw 89 9 most most RBS cord-339015-qn8wbnlw 89 10 common common JJ cord-339015-qn8wbnlw 89 11 GI GI NNP cord-339015-qn8wbnlw 89 12 virus virus NN cord-339015-qn8wbnlw 89 13 for for IN cord-339015-qn8wbnlw 89 14 infants infant NNS cord-339015-qn8wbnlw 89 15 ) ) -RRB- cord-339015-qn8wbnlw 89 16 3 3 CD cord-339015-qn8wbnlw 89 17 . . . cord-339015-qn8wbnlw 90 1 Systemic systemic JJ cord-339015-qn8wbnlw 90 2 disease disease NN cord-339015-qn8wbnlw 90 3 , , , cord-339015-qn8wbnlw 90 4 such such JJ cord-339015-qn8wbnlw 90 5 as as IN cord-339015-qn8wbnlw 90 6 enterovirus enterovirus NN cord-339015-qn8wbnlw 90 7 and and CC cord-339015-qn8wbnlw 90 8 parechovirus parechovirus NNP cord-339015-qn8wbnlw 90 9 In in IN cord-339015-qn8wbnlw 90 10 critically critically RB cord-339015-qn8wbnlw 90 11 ill ill JJ cord-339015-qn8wbnlw 90 12 patients patient NNS cord-339015-qn8wbnlw 90 13 , , , cord-339015-qn8wbnlw 90 14 central central JJ cord-339015-qn8wbnlw 90 15 nervous nervous JJ cord-339015-qn8wbnlw 90 16 infections infection NNS cord-339015-qn8wbnlw 90 17 , , , cord-339015-qn8wbnlw 90 18 such such JJ cord-339015-qn8wbnlw 90 19 as as IN cord-339015-qn8wbnlw 90 20 meningitis meningitis NN cord-339015-qn8wbnlw 90 21 and and CC cord-339015-qn8wbnlw 90 22 encephalitis encephalitis RB cord-339015-qn8wbnlw 90 23 , , , cord-339015-qn8wbnlw 90 24 cause cause VBP cord-339015-qn8wbnlw 90 25 significant significant JJ cord-339015-qn8wbnlw 90 26 morbidity morbidity NN cord-339015-qn8wbnlw 90 27 and and CC cord-339015-qn8wbnlw 90 28 mortality mortality NN cord-339015-qn8wbnlw 90 29 if if IN cord-339015-qn8wbnlw 90 30 not not RB cord-339015-qn8wbnlw 90 31 diagnosed diagnose VBN cord-339015-qn8wbnlw 90 32 early early RB cord-339015-qn8wbnlw 90 33 and and CC cord-339015-qn8wbnlw 90 34 treated treat VBN cord-339015-qn8wbnlw 90 35 promptly promptly RB cord-339015-qn8wbnlw 90 36 . . . cord-339015-qn8wbnlw 91 1 Bacterial bacterial JJ cord-339015-qn8wbnlw 91 2 infections infection NNS cord-339015-qn8wbnlw 91 3 can can MD cord-339015-qn8wbnlw 91 4 lead lead VB cord-339015-qn8wbnlw 91 5 to to IN cord-339015-qn8wbnlw 91 6 meningitis meningitis NN cord-339015-qn8wbnlw 91 7 , , , cord-339015-qn8wbnlw 91 8 brain brain NN cord-339015-qn8wbnlw 91 9 abscess abscess NN cord-339015-qn8wbnlw 91 10 , , , cord-339015-qn8wbnlw 91 11 subdural subdural JJ cord-339015-qn8wbnlw 91 12 empyema empyema NN cord-339015-qn8wbnlw 91 13 , , , cord-339015-qn8wbnlw 91 14 and and CC cord-339015-qn8wbnlw 91 15 sepsis sepsis NN cord-339015-qn8wbnlw 91 16 . . . cord-339015-qn8wbnlw 92 1 Viral viral JJ cord-339015-qn8wbnlw 92 2 infections infection NNS cord-339015-qn8wbnlw 92 3 can can MD cord-339015-qn8wbnlw 92 4 also also RB cord-339015-qn8wbnlw 92 5 cause cause VB cord-339015-qn8wbnlw 92 6 meningitis meningitis NN cord-339015-qn8wbnlw 92 7 , , , cord-339015-qn8wbnlw 92 8 encephalitis encephalitis RB cord-339015-qn8wbnlw 92 9 , , , cord-339015-qn8wbnlw 92 10 optic optic JJ cord-339015-qn8wbnlw 92 11 neuritis neuritis NN cord-339015-qn8wbnlw 92 12 , , , cord-339015-qn8wbnlw 92 13 and and CC cord-339015-qn8wbnlw 92 14 poliomyelitis poliomyelitis NN cord-339015-qn8wbnlw 92 15 . . . cord-339015-qn8wbnlw 92 16 _SP cord-339015-qn8wbnlw 93 1 Meningitis meningitis NN cord-339015-qn8wbnlw 93 2 is be VBZ cord-339015-qn8wbnlw 93 3 characterized characterize VBN cord-339015-qn8wbnlw 93 4 by by IN cord-339015-qn8wbnlw 93 5 the the DT cord-339015-qn8wbnlw 93 6 inflammation inflammation NN cord-339015-qn8wbnlw 93 7 of of IN cord-339015-qn8wbnlw 93 8 the the DT cord-339015-qn8wbnlw 93 9 meninges meninge NNS cord-339015-qn8wbnlw 93 10 surrounding surround VBG cord-339015-qn8wbnlw 93 11 the the DT cord-339015-qn8wbnlw 93 12 brain brain NN cord-339015-qn8wbnlw 93 13 and and CC cord-339015-qn8wbnlw 93 14 the the DT cord-339015-qn8wbnlw 93 15 spinal spinal JJ cord-339015-qn8wbnlw 93 16 cord cord NN cord-339015-qn8wbnlw 93 17 . . . cord-339015-qn8wbnlw 94 1 A a DT cord-339015-qn8wbnlw 94 2 triad triad NN cord-339015-qn8wbnlw 94 3 of of IN cord-339015-qn8wbnlw 94 4 fever fever NN cord-339015-qn8wbnlw 94 5 , , , cord-339015-qn8wbnlw 94 6 nuchal nuchal NN cord-339015-qn8wbnlw 94 7 rigidity rigidity NN cord-339015-qn8wbnlw 94 8 , , , cord-339015-qn8wbnlw 94 9 and and CC cord-339015-qn8wbnlw 94 10 altered alter VBN cord-339015-qn8wbnlw 94 11 mental mental JJ cord-339015-qn8wbnlw 94 12 status status NN cord-339015-qn8wbnlw 94 13 in in IN cord-339015-qn8wbnlw 94 14 most most JJS cord-339015-qn8wbnlw 94 15 but but CC cord-339015-qn8wbnlw 94 16 not not RB cord-339015-qn8wbnlw 94 17 all all DT cord-339015-qn8wbnlw 94 18 patients patient NNS cord-339015-qn8wbnlw 94 19 Cranial cranial JJ cord-339015-qn8wbnlw 94 20 nerve nerve NN cord-339015-qn8wbnlw 94 21 palsies palsy NNS cord-339015-qn8wbnlw 94 22 , , , cord-339015-qn8wbnlw 94 23 nausea nausea NN cord-339015-qn8wbnlw 94 24 , , , cord-339015-qn8wbnlw 94 25 vomiting vomiting NN cord-339015-qn8wbnlw 94 26 , , , cord-339015-qn8wbnlw 94 27 headaches headache NNS cord-339015-qn8wbnlw 94 28 , , , cord-339015-qn8wbnlw 94 29 and and CC cord-339015-qn8wbnlw 94 30 photophobia photophobia NN cord-339015-qn8wbnlw 94 31 Encephalitis encephalitis RB cord-339015-qn8wbnlw 94 32 is be VBZ cord-339015-qn8wbnlw 94 33 inflammation inflammation NN cord-339015-qn8wbnlw 94 34 within within IN cord-339015-qn8wbnlw 94 35 the the DT cord-339015-qn8wbnlw 94 36 brain brain NN cord-339015-qn8wbnlw 94 37 parenchyma parenchyma NN cord-339015-qn8wbnlw 94 38 . . . cord-339015-qn8wbnlw 95 1 Clinical clinical JJ cord-339015-qn8wbnlw 95 2 presentation presentation NN cord-339015-qn8wbnlw 95 3 is be VBZ cord-339015-qn8wbnlw 95 4 variable variable JJ cord-339015-qn8wbnlw 95 5 depending depend VBG cord-339015-qn8wbnlw 95 6 on on IN cord-339015-qn8wbnlw 95 7 the the DT cord-339015-qn8wbnlw 95 8 brain brain NN cord-339015-qn8wbnlw 95 9 cells cell NNS cord-339015-qn8wbnlw 95 10 affected affect VBN cord-339015-qn8wbnlw 95 11 . . . cord-339015-qn8wbnlw 96 1 Patients patient NNS cord-339015-qn8wbnlw 96 2 are be VBP cord-339015-qn8wbnlw 96 3 more more RBR cord-339015-qn8wbnlw 96 4 likely likely JJ cord-339015-qn8wbnlw 96 5 to to TO cord-339015-qn8wbnlw 96 6 present present VB cord-339015-qn8wbnlw 96 7 with with IN cord-339015-qn8wbnlw 96 8 altered altered JJ cord-339015-qn8wbnlw 96 9 level level NN cord-339015-qn8wbnlw 96 10 of of IN cord-339015-qn8wbnlw 96 11 conscience conscience NN cord-339015-qn8wbnlw 96 12 or or CC cord-339015-qn8wbnlw 96 13 confusion confusion NN cord-339015-qn8wbnlw 96 14 , , , cord-339015-qn8wbnlw 96 15 coma coma NN cord-339015-qn8wbnlw 96 16 , , , cord-339015-qn8wbnlw 96 17 and and CC cord-339015-qn8wbnlw 96 18 focal focal JJ cord-339015-qn8wbnlw 96 19 or or CC cord-339015-qn8wbnlw 96 20 generalized generalized JJ cord-339015-qn8wbnlw 96 21 seizures seizure NNS cord-339015-qn8wbnlw 96 22 . . . cord-339015-qn8wbnlw 97 1 Suspected suspect VBN cord-339015-qn8wbnlw 97 2 patients patient NNS cord-339015-qn8wbnlw 97 3 should should MD cord-339015-qn8wbnlw 97 4 receive receive VB cord-339015-qn8wbnlw 97 5 neuroimaging neuroimaging NN cord-339015-qn8wbnlw 97 6 before before IN cord-339015-qn8wbnlw 97 7 lumbar lumbar NN cord-339015-qn8wbnlw 97 8 puncture puncture NN cord-339015-qn8wbnlw 97 9 . . . cord-339015-qn8wbnlw 98 1 9 9 CD cord-339015-qn8wbnlw 98 2 Bacterial bacterial JJ cord-339015-qn8wbnlw 98 3 meningitis meningitis NN cord-339015-qn8wbnlw 98 4 is be VBZ cord-339015-qn8wbnlw 98 5 confirmed confirm VBN cord-339015-qn8wbnlw 98 6 by by IN cord-339015-qn8wbnlw 98 7 cerebrospinal cerebrospinal NN cord-339015-qn8wbnlw 98 8 fluid fluid NN cord-339015-qn8wbnlw 98 9 ( ( -LRB- cord-339015-qn8wbnlw 98 10 CSF CSF NNP cord-339015-qn8wbnlw 98 11 ) ) -RRB- cord-339015-qn8wbnlw 98 12 . . . cord-339015-qn8wbnlw 99 1 Positive positive JJ cord-339015-qn8wbnlw 99 2 findings finding NNS cord-339015-qn8wbnlw 99 3 for for IN cord-339015-qn8wbnlw 99 4 bacterial bacterial JJ cord-339015-qn8wbnlw 99 5 meningitis meningitis NN cord-339015-qn8wbnlw 99 6 include include VBP cord-339015-qn8wbnlw 99 7 Elevated elevated JJ cord-339015-qn8wbnlw 99 8 opening opening NN cord-339015-qn8wbnlw 99 9 pressure pressure NN cord-339015-qn8wbnlw 99 10 Polymorphonuclear polymorphonuclear JJ cord-339015-qn8wbnlw 99 11 cell cell NN cord-339015-qn8wbnlw 99 12 predominance predominance NN cord-339015-qn8wbnlw 99 13 Decreased decrease VBD cord-339015-qn8wbnlw 99 14 glucose glucose NN cord-339015-qn8wbnlw 99 15 concentration concentration NN cord-339015-qn8wbnlw 99 16 Elevated elevated JJ cord-339015-qn8wbnlw 99 17 protein protein NN cord-339015-qn8wbnlw 99 18 concentration concentration NN cord-339015-qn8wbnlw 100 1 In in IN cord-339015-qn8wbnlw 100 2 viral viral JJ cord-339015-qn8wbnlw 100 3 meningitis meningitis NN cord-339015-qn8wbnlw 100 4 , , , cord-339015-qn8wbnlw 100 5 opening open VBG cord-339015-qn8wbnlw 100 6 pressure pressure NN cord-339015-qn8wbnlw 100 7 is be VBZ cord-339015-qn8wbnlw 100 8 usually usually RB cord-339015-qn8wbnlw 100 9 normal normal JJ cord-339015-qn8wbnlw 100 10 , , , cord-339015-qn8wbnlw 100 11 there there EX cord-339015-qn8wbnlw 100 12 is be VBZ cord-339015-qn8wbnlw 100 13 lymphocyte lymphocyte NN cord-339015-qn8wbnlw 100 14 predominance predominance NN cord-339015-qn8wbnlw 100 15 , , , cord-339015-qn8wbnlw 100 16 and and CC cord-339015-qn8wbnlw 100 17 CSF csf NN cord-339015-qn8wbnlw 100 18 glucose glucose NN cord-339015-qn8wbnlw 100 19 is be VBZ cord-339015-qn8wbnlw 100 20 usually usually RB cord-339015-qn8wbnlw 100 21 normal normal JJ cord-339015-qn8wbnlw 100 22 . . . cord-339015-qn8wbnlw 101 1 The the DT cord-339015-qn8wbnlw 101 2 antimicrobial antimicrobial JJ cord-339015-qn8wbnlw 101 3 agent agent NN cord-339015-qn8wbnlw 101 4 of of IN cord-339015-qn8wbnlw 101 5 choice choice NN cord-339015-qn8wbnlw 101 6 must must MD cord-339015-qn8wbnlw 101 7 penetrate penetrate VB cord-339015-qn8wbnlw 101 8 the the DT cord-339015-qn8wbnlw 101 9 blood blood NN cord-339015-qn8wbnlw 101 10 - - HYPH cord-339015-qn8wbnlw 101 11 brain brain NN cord-339015-qn8wbnlw 101 12 barrier barrier NN cord-339015-qn8wbnlw 101 13 and and CC cord-339015-qn8wbnlw 101 14 should should MD cord-339015-qn8wbnlw 101 15 be be VB cord-339015-qn8wbnlw 101 16 based base VBN cord-339015-qn8wbnlw 101 17 on on IN cord-339015-qn8wbnlw 101 18 patient patient JJ cord-339015-qn8wbnlw 101 19 age age NN cord-339015-qn8wbnlw 101 20 and and CC cord-339015-qn8wbnlw 101 21 risk risk NN cord-339015-qn8wbnlw 101 22 factors factor NNS cord-339015-qn8wbnlw 101 23 . . . cord-339015-qn8wbnlw 102 1 Vancomycin Vancomycin NNP cord-339015-qn8wbnlw 102 2 plus plus CC cord-339015-qn8wbnlw 102 3 ceftriaxone ceftriaxone NN cord-339015-qn8wbnlw 102 4 is be VBZ cord-339015-qn8wbnlw 102 5 the the DT cord-339015-qn8wbnlw 102 6 preferred preferred JJ cord-339015-qn8wbnlw 102 7 empiric empiric JJ cord-339015-qn8wbnlw 102 8 therapy therapy NN cord-339015-qn8wbnlw 102 9 . . . cord-339015-qn8wbnlw 103 1 Ampicillin Ampicillin NNP cord-339015-qn8wbnlw 103 2 should should MD cord-339015-qn8wbnlw 103 3 be be VB cord-339015-qn8wbnlw 103 4 added add VBN cord-339015-qn8wbnlw 103 5 to to IN cord-339015-qn8wbnlw 103 6 the the DT cord-339015-qn8wbnlw 103 7 initial initial JJ cord-339015-qn8wbnlw 103 8 empiric empiric JJ cord-339015-qn8wbnlw 103 9 therapy therapy NN cord-339015-qn8wbnlw 103 10 in in IN cord-339015-qn8wbnlw 103 11 children child NNS cord-339015-qn8wbnlw 103 12 , , , cord-339015-qn8wbnlw 103 13 immunocompromised immunocompromised JJ cord-339015-qn8wbnlw 103 14 hosts host NNS cord-339015-qn8wbnlw 103 15 , , , cord-339015-qn8wbnlw 103 16 and and CC cord-339015-qn8wbnlw 103 17 the the DT cord-339015-qn8wbnlw 103 18 elderly elderly JJ cord-339015-qn8wbnlw 103 19 ( ( -LRB- cord-339015-qn8wbnlw 103 20 > > NFP cord-339015-qn8wbnlw 103 21 50 50 CD cord-339015-qn8wbnlw 103 22 years year NNS cord-339015-qn8wbnlw 103 23 ) ) -RRB- cord-339015-qn8wbnlw 103 24 . . . cord-339015-qn8wbnlw 104 1 2 2 LS cord-339015-qn8wbnlw 104 2 Patients patient NNS cord-339015-qn8wbnlw 104 3 with with IN cord-339015-qn8wbnlw 104 4 viral viral JJ cord-339015-qn8wbnlw 104 5 encephalitis encephalitis NN cord-339015-qn8wbnlw 104 6 can can MD cord-339015-qn8wbnlw 104 7 be be VB cord-339015-qn8wbnlw 104 8 managed manage VBN cord-339015-qn8wbnlw 104 9 with with IN cord-339015-qn8wbnlw 104 10 acyclovir acyclovir NNP cord-339015-qn8wbnlw 104 11 . . . cord-339015-qn8wbnlw 105 1 respiratory respiratory JJ cord-339015-qn8wbnlw 105 2 secretions secretion NNS cord-339015-qn8wbnlw 105 3 by by IN cord-339015-qn8wbnlw 105 4 PCR PCR NNP cord-339015-qn8wbnlw 105 5 . . . cord-339015-qn8wbnlw 106 1 HSV HSV NNP cord-339015-qn8wbnlw 106 2 and and CC cord-339015-qn8wbnlw 106 3 CMV CMV NNP cord-339015-qn8wbnlw 106 4 are be VBP cord-339015-qn8wbnlw 106 5 responsive responsive JJ cord-339015-qn8wbnlw 106 6 to to IN cord-339015-qn8wbnlw 106 7 treatment treatment NN cord-339015-qn8wbnlw 106 8 with with IN cord-339015-qn8wbnlw 106 9 acyclovir acyclovir NNP cord-339015-qn8wbnlw 106 10 and and CC cord-339015-qn8wbnlw 106 11 ganciclovir ganciclovir NNS cord-339015-qn8wbnlw 106 12 , , , cord-339015-qn8wbnlw 106 13 respectively respectively RB cord-339015-qn8wbnlw 106 14 . . . cord-339015-qn8wbnlw 107 1 APPs app NNS cord-339015-qn8wbnlw 107 2 should should MD cord-339015-qn8wbnlw 107 3 ensure ensure VB cord-339015-qn8wbnlw 107 4 universal universal JJ cord-339015-qn8wbnlw 107 5 control control NN cord-339015-qn8wbnlw 107 6 precautions precaution NNS cord-339015-qn8wbnlw 107 7 when when WRB cord-339015-qn8wbnlw 107 8 managing manage VBG cord-339015-qn8wbnlw 107 9 these these DT cord-339015-qn8wbnlw 107 10 patients patient NNS cord-339015-qn8wbnlw 107 11 . . . cord-339015-qn8wbnlw 108 1 Patients patient NNS cord-339015-qn8wbnlw 108 2 in in IN cord-339015-qn8wbnlw 108 3 ICUs icu NNS cord-339015-qn8wbnlw 108 4 are be VBP cord-339015-qn8wbnlw 108 5 more more RBR cord-339015-qn8wbnlw 108 6 prone prone JJ cord-339015-qn8wbnlw 108 7 to to IN cord-339015-qn8wbnlw 108 8 infections infection NNS cord-339015-qn8wbnlw 108 9 and and CC cord-339015-qn8wbnlw 108 10 are be VBP cord-339015-qn8wbnlw 108 11 more more RBR cord-339015-qn8wbnlw 108 12 likely likely JJ cord-339015-qn8wbnlw 108 13 develop develop VB cord-339015-qn8wbnlw 108 14 multidrugresistant multidrugresistant NN cord-339015-qn8wbnlw 108 15 organisms organism NNS cord-339015-qn8wbnlw 108 16 and and CC cord-339015-qn8wbnlw 108 17 have have VBP cord-339015-qn8wbnlw 108 18 poor poor JJ cord-339015-qn8wbnlw 108 19 outcomes outcome NNS cord-339015-qn8wbnlw 108 20 . . . cord-339015-qn8wbnlw 109 1 Multidrug multidrug JJ cord-339015-qn8wbnlw 109 2 resistance resistance NN cord-339015-qn8wbnlw 109 3 increases increase VBZ cord-339015-qn8wbnlw 109 4 mortality mortality NN cord-339015-qn8wbnlw 109 5 and and CC cord-339015-qn8wbnlw 109 6 length length NN cord-339015-qn8wbnlw 109 7 of of IN cord-339015-qn8wbnlw 109 8 stay stay NN cord-339015-qn8wbnlw 109 9 and and CC cord-339015-qn8wbnlw 109 10 is be VBZ cord-339015-qn8wbnlw 109 11 largely largely RB cord-339015-qn8wbnlw 109 12 responsible responsible JJ cord-339015-qn8wbnlw 109 13 for for IN cord-339015-qn8wbnlw 109 14 the the DT cord-339015-qn8wbnlw 109 15 escalating escalate VBG cord-339015-qn8wbnlw 109 16 health health NN cord-339015-qn8wbnlw 109 17 care care NN cord-339015-qn8wbnlw 109 18 costs cost NNS cord-339015-qn8wbnlw 109 19 in in IN cord-339015-qn8wbnlw 109 20 the the DT cord-339015-qn8wbnlw 109 21 United United NNP cord-339015-qn8wbnlw 109 22 States States NNP cord-339015-qn8wbnlw 109 23 . . . cord-339015-qn8wbnlw 110 1 10 10 CD cord-339015-qn8wbnlw 110 2 , , , cord-339015-qn8wbnlw 110 3 11 11 CD cord-339015-qn8wbnlw 111 1 The the DT cord-339015-qn8wbnlw 111 2 clinical clinical JJ cord-339015-qn8wbnlw 111 3 manifestations manifestation NNS cord-339015-qn8wbnlw 111 4 of of IN cord-339015-qn8wbnlw 111 5 bacterial bacterial JJ cord-339015-qn8wbnlw 111 6 and and CC cord-339015-qn8wbnlw 111 7 viral viral JJ cord-339015-qn8wbnlw 111 8 infections infection NNS cord-339015-qn8wbnlw 111 9 are be VBP cord-339015-qn8wbnlw 111 10 highly highly RB cord-339015-qn8wbnlw 111 11 variable variable JJ cord-339015-qn8wbnlw 111 12 in in IN cord-339015-qn8wbnlw 111 13 the the DT cord-339015-qn8wbnlw 111 14 ICU ICU NNP cord-339015-qn8wbnlw 111 15 patient patient NN cord-339015-qn8wbnlw 111 16 , , , cord-339015-qn8wbnlw 111 17 ranging range VBG cord-339015-qn8wbnlw 111 18 from from IN cord-339015-qn8wbnlw 111 19 severe severe JJ cord-339015-qn8wbnlw 111 20 respiratory respiratory JJ cord-339015-qn8wbnlw 111 21 disease disease NN cord-339015-qn8wbnlw 111 22 to to IN cord-339015-qn8wbnlw 111 23 sepsis sepsis NN cord-339015-qn8wbnlw 112 1 ( ( -LRB- cord-339015-qn8wbnlw 112 2 Box Box NNP cord-339015-qn8wbnlw 112 3 5 5 CD cord-339015-qn8wbnlw 112 4 ) ) -RRB- cord-339015-qn8wbnlw 112 5 . . . cord-339015-qn8wbnlw 113 1 Early early JJ cord-339015-qn8wbnlw 113 2 recognition recognition NN cord-339015-qn8wbnlw 113 3 and and CC cord-339015-qn8wbnlw 113 4 empiric empiric JJ cord-339015-qn8wbnlw 113 5 therapy therapy NN cord-339015-qn8wbnlw 113 6 are be VBP cord-339015-qn8wbnlw 113 7 recommended recommend VBN cord-339015-qn8wbnlw 113 8 but but CC cord-339015-qn8wbnlw 113 9 APPs app NNS cord-339015-qn8wbnlw 113 10 must must MD cord-339015-qn8wbnlw 113 11 use use VB cord-339015-qn8wbnlw 113 12 antibiotics antibiotic NNS cord-339015-qn8wbnlw 113 13 wisely wisely RB cord-339015-qn8wbnlw 113 14 . . . cord-339015-qn8wbnlw 114 1 ICU ICU NNP cord-339015-qn8wbnlw 114 2 APPs app NNS cord-339015-qn8wbnlw 114 3 should should MD cord-339015-qn8wbnlw 114 4 use use VB cord-339015-qn8wbnlw 114 5 appropriate appropriate JJ cord-339015-qn8wbnlw 114 6 initial initial JJ cord-339015-qn8wbnlw 114 7 empiric empiric JJ cord-339015-qn8wbnlw 114 8 therapy therapy NN cord-339015-qn8wbnlw 114 9 and and CC cord-339015-qn8wbnlw 114 10 de de NN cord-339015-qn8wbnlw 114 11 - - NN cord-339015-qn8wbnlw 114 12 escalate escalate VB cord-339015-qn8wbnlw 114 13 once once IN cord-339015-qn8wbnlw 114 14 cultures culture NNS cord-339015-qn8wbnlw 114 15 and and CC cord-339015-qn8wbnlw 114 16 Box Box NNP cord-339015-qn8wbnlw 114 17 5 5 CD cord-339015-qn8wbnlw 114 18 Dealing deal VBG cord-339015-qn8wbnlw 114 19 with with IN cord-339015-qn8wbnlw 114 20 sepsis sepsis NN cord-339015-qn8wbnlw 114 21 and and CC cord-339015-qn8wbnlw 114 22 systemic systemic JJ cord-339015-qn8wbnlw 114 23 inflammatory inflammatory JJ cord-339015-qn8wbnlw 114 24 response response NN cord-339015-qn8wbnlw 114 25 syndrome syndrome NN cord-339015-qn8wbnlw 114 26 in in IN cord-339015-qn8wbnlw 114 27 the the DT cord-339015-qn8wbnlw 114 28 ICU ICU NNP cord-339015-qn8wbnlw 114 29 Sepsis Sepsis NNP cord-339015-qn8wbnlw 114 30 is be VBZ cord-339015-qn8wbnlw 114 31 a a DT cord-339015-qn8wbnlw 114 32 systemic systemic JJ cord-339015-qn8wbnlw 114 33 inflammatory inflammatory JJ cord-339015-qn8wbnlw 114 34 response response NN cord-339015-qn8wbnlw 114 35 syndrome syndrome NN cord-339015-qn8wbnlw 114 36 that that WDT cord-339015-qn8wbnlw 114 37 results result VBZ cord-339015-qn8wbnlw 114 38 from from IN cord-339015-qn8wbnlw 114 39 an an DT cord-339015-qn8wbnlw 114 40 infection infection NN cord-339015-qn8wbnlw 114 41 . . . cord-339015-qn8wbnlw 115 1 Sepsis sepsis NN cord-339015-qn8wbnlw 115 2 is be VBZ cord-339015-qn8wbnlw 115 3 described describe VBN cord-339015-qn8wbnlw 115 4 as as IN cord-339015-qn8wbnlw 115 5 severe severe JJ cord-339015-qn8wbnlw 115 6 if if IN cord-339015-qn8wbnlw 115 7 a a DT cord-339015-qn8wbnlw 115 8 patient patient NN cord-339015-qn8wbnlw 115 9 develops develop VBZ cord-339015-qn8wbnlw 115 10 end end NN cord-339015-qn8wbnlw 115 11 - - HYPH cord-339015-qn8wbnlw 115 12 organ organ NN cord-339015-qn8wbnlw 115 13 dysfunction dysfunction NN cord-339015-qn8wbnlw 115 14 and and CC cord-339015-qn8wbnlw 115 15 hypotension hypotension NN cord-339015-qn8wbnlw 115 16 that that WDT cord-339015-qn8wbnlw 115 17 is be VBZ cord-339015-qn8wbnlw 115 18 not not RB cord-339015-qn8wbnlw 115 19 responsive responsive JJ cord-339015-qn8wbnlw 115 20 to to IN cord-339015-qn8wbnlw 115 21 fluid fluid JJ cord-339015-qn8wbnlw 115 22 resuscitation resuscitation NN cord-339015-qn8wbnlw 115 23 . . . cord-339015-qn8wbnlw 116 1 The the DT cord-339015-qn8wbnlw 116 2 spectrum spectrum NN cord-339015-qn8wbnlw 116 3 of of IN cord-339015-qn8wbnlw 116 4 sepsis sepsis NN cord-339015-qn8wbnlw 116 5 causing cause VBG cord-339015-qn8wbnlw 116 6 pathogens pathogen NNS cord-339015-qn8wbnlw 116 7 is be VBZ cord-339015-qn8wbnlw 116 8 rapidly rapidly RB cord-339015-qn8wbnlw 116 9 changing change VBG cord-339015-qn8wbnlw 116 10 from from IN cord-339015-qn8wbnlw 116 11 predominantly predominantly RB cord-339015-qn8wbnlw 116 12 gramnegative gramnegative JJ cord-339015-qn8wbnlw 116 13 organisms organism NNS cord-339015-qn8wbnlw 116 14 to to IN cord-339015-qn8wbnlw 116 15 gram gram VB cord-339015-qn8wbnlw 116 16 - - HYPH cord-339015-qn8wbnlw 116 17 positive positive JJ cord-339015-qn8wbnlw 116 18 organisms organism NNS cord-339015-qn8wbnlw 116 19 . . . cord-339015-qn8wbnlw 117 1 Hemodynamic Hemodynamic NNP cord-339015-qn8wbnlw 117 2 and and CC cord-339015-qn8wbnlw 117 3 tissue tissue NN cord-339015-qn8wbnlw 117 4 perfusion perfusion NN cord-339015-qn8wbnlw 117 5 changes change NNS cord-339015-qn8wbnlw 117 6 in in IN cord-339015-qn8wbnlw 117 7 a a DT cord-339015-qn8wbnlw 117 8 septic septic JJ cord-339015-qn8wbnlw 117 9 patient patient NN cord-339015-qn8wbnlw 117 10 may may MD cord-339015-qn8wbnlw 117 11 include include VB cord-339015-qn8wbnlw 118 1 Arterial arterial JJ cord-339015-qn8wbnlw 118 2 hypotension hypotension NN cord-339015-qn8wbnlw 118 3 Hyperlactatemia hyperlactatemia NN cord-339015-qn8wbnlw 118 4 ( ( -LRB- cord-339015-qn8wbnlw 118 5 > > NFP cord-339015-qn8wbnlw 118 6 1 1 CD cord-339015-qn8wbnlw 118 7 mmol mmol NNP cord-339015-qn8wbnlw 118 8 / / SYM cord-339015-qn8wbnlw 118 9 L l NN cord-339015-qn8wbnlw 118 10 ) ) -RRB- cord-339015-qn8wbnlw 118 11 Decreased decrease VBD cord-339015-qn8wbnlw 118 12 capillary capillary JJ cord-339015-qn8wbnlw 118 13 refill refill NN cord-339015-qn8wbnlw 119 1 When when WRB cord-339015-qn8wbnlw 119 2 sepsis sepsis NN cord-339015-qn8wbnlw 119 3 is be VBZ cord-339015-qn8wbnlw 119 4 suspected suspect VBN cord-339015-qn8wbnlw 119 5 , , , cord-339015-qn8wbnlw 119 6 clinicians clinician NNS cord-339015-qn8wbnlw 119 7 should should MD cord-339015-qn8wbnlw 119 8 rapidly rapidly RB cord-339015-qn8wbnlw 119 9 administer administer VB cord-339015-qn8wbnlw 119 10 broad broad JJ cord-339015-qn8wbnlw 119 11 - - HYPH cord-339015-qn8wbnlw 119 12 spectrum spectrum NN cord-339015-qn8wbnlw 119 13 antibiotics antibiotic NNS cord-339015-qn8wbnlw 119 14 . . . cord-339015-qn8wbnlw 120 1 The the DT cord-339015-qn8wbnlw 120 2 Surviving Surviving NNP cord-339015-qn8wbnlw 120 3 Sepsis Sepsis NNP cord-339015-qn8wbnlw 120 4 Campaign Campaign NNP cord-339015-qn8wbnlw 120 5 bundle bundle NN cord-339015-qn8wbnlw 120 6 12 12 CD cord-339015-qn8wbnlw 120 7 recommends recommend VBZ cord-339015-qn8wbnlw 120 8 the the DT cord-339015-qn8wbnlw 120 9 following follow VBG cord-339015-qn8wbnlw 120 10 : : : cord-339015-qn8wbnlw 120 11 Measure measure NN cord-339015-qn8wbnlw 120 12 and and CC cord-339015-qn8wbnlw 120 13 monitor monitor VB cord-339015-qn8wbnlw 120 14 lactate lactate NN cord-339015-qn8wbnlw 120 15 level level NN cord-339015-qn8wbnlw 120 16 . . . cord-339015-qn8wbnlw 121 1 Obtain obtain VB cord-339015-qn8wbnlw 121 2 blood blood NN cord-339015-qn8wbnlw 121 3 cultures culture NNS cord-339015-qn8wbnlw 121 4 prior prior RB cord-339015-qn8wbnlw 121 5 to to IN cord-339015-qn8wbnlw 121 6 administration administration NN cord-339015-qn8wbnlw 121 7 of of IN cord-339015-qn8wbnlw 121 8 antibiotics antibiotic NNS cord-339015-qn8wbnlw 121 9 . . . cord-339015-qn8wbnlw 122 1 Begin begin VB cord-339015-qn8wbnlw 122 2 rapid rapid JJ cord-339015-qn8wbnlw 122 3 administration administration NN cord-339015-qn8wbnlw 122 4 of of IN cord-339015-qn8wbnlw 122 5 crystalloid crystalloid NNP cord-339015-qn8wbnlw 122 6 to to TO cord-339015-qn8wbnlw 122 7 manage manage VB cord-339015-qn8wbnlw 122 8 hypotension hypotension NN cord-339015-qn8wbnlw 122 9 and and CC cord-339015-qn8wbnlw 122 10 elevated elevated JJ cord-339015-qn8wbnlw 122 11 lactate lactate NN cord-339015-qn8wbnlw 122 12 ( ( -LRB- cord-339015-qn8wbnlw 122 13 > > NFP cord-339015-qn8wbnlw 122 14 4 4 CD cord-339015-qn8wbnlw 122 15 mmol mmol NNP cord-339015-qn8wbnlw 122 16 / / SYM cord-339015-qn8wbnlw 122 17 L L NNP cord-339015-qn8wbnlw 122 18 ) ) -RRB- cord-339015-qn8wbnlw 122 19 . . . cord-339015-qn8wbnlw 123 1 Apply apply VB cord-339015-qn8wbnlw 123 2 vasopressors vasopressor NNS cord-339015-qn8wbnlw 123 3 if if IN cord-339015-qn8wbnlw 123 4 patient patient NN cord-339015-qn8wbnlw 123 5 is be VBZ cord-339015-qn8wbnlw 123 6 hypotensive hypotensive JJ cord-339015-qn8wbnlw 123 7 during during IN cord-339015-qn8wbnlw 123 8 or or CC cord-339015-qn8wbnlw 123 9 after after IN cord-339015-qn8wbnlw 123 10 fluid fluid JJ cord-339015-qn8wbnlw 123 11 resuscitation resuscitation NN cord-339015-qn8wbnlw 123 12 to to TO cord-339015-qn8wbnlw 123 13 maintain maintain VB cord-339015-qn8wbnlw 123 14 mean mean JJ cord-339015-qn8wbnlw 123 15 arterial arterial JJ cord-339015-qn8wbnlw 123 16 pressure pressure NN cord-339015-qn8wbnlw 123 17 65 65 CD cord-339015-qn8wbnlw 123 18 mm mm NN cord-339015-qn8wbnlw 124 1 Hg Hg NNP cord-339015-qn8wbnlw 124 2 . . . cord-339015-qn8wbnlw 125 1 Managing manage VBG cord-339015-qn8wbnlw 125 2 a a DT cord-339015-qn8wbnlw 125 3 sepsis sepsis NN cord-339015-qn8wbnlw 125 4 patient patient NN cord-339015-qn8wbnlw 125 5 involves involve VBZ cord-339015-qn8wbnlw 125 6 a a DT cord-339015-qn8wbnlw 125 7 lot lot NN cord-339015-qn8wbnlw 125 8 of of IN cord-339015-qn8wbnlw 125 9 supportive supportive JJ cord-339015-qn8wbnlw 125 10 care care NN cord-339015-qn8wbnlw 125 11 . . . cord-339015-qn8wbnlw 126 1 The the DT cord-339015-qn8wbnlw 126 2 first first JJ cord-339015-qn8wbnlw 126 3 few few JJ cord-339015-qn8wbnlw 126 4 hours hour NNS cord-339015-qn8wbnlw 126 5 should should MD cord-339015-qn8wbnlw 126 6 be be VB cord-339015-qn8wbnlw 126 7 dedicated dedicate VBN cord-339015-qn8wbnlw 126 8 to to IN cord-339015-qn8wbnlw 126 9 restoring restore VBG cord-339015-qn8wbnlw 126 10 adequate adequate JJ cord-339015-qn8wbnlw 126 11 perfusion perfusion NN cord-339015-qn8wbnlw 126 12 , , , cord-339015-qn8wbnlw 126 13 providing provide VBG cord-339015-qn8wbnlw 126 14 antibiotics antibiotic NNS cord-339015-qn8wbnlw 126 15 , , , cord-339015-qn8wbnlw 126 16 and and CC cord-339015-qn8wbnlw 126 17 optimizing optimize VBG cord-339015-qn8wbnlw 126 18 oxygen oxygen NN cord-339015-qn8wbnlw 126 19 supply supply NN cord-339015-qn8wbnlw 126 20 and and CC cord-339015-qn8wbnlw 126 21 demand demand NN cord-339015-qn8wbnlw 126 22 susceptibility susceptibility NN cord-339015-qn8wbnlw 126 23 data datum NNS cord-339015-qn8wbnlw 126 24 are be VBP cord-339015-qn8wbnlw 126 25 available available JJ cord-339015-qn8wbnlw 126 26 . . . cord-339015-qn8wbnlw 127 1 The the DT cord-339015-qn8wbnlw 127 2 emerging emerge VBG cord-339015-qn8wbnlw 127 3 and and CC cord-339015-qn8wbnlw 127 4 re re JJ cord-339015-qn8wbnlw 127 5 - - JJ cord-339015-qn8wbnlw 127 6 emerging emerge VBG cord-339015-qn8wbnlw 127 7 infectious infectious JJ cord-339015-qn8wbnlw 127 8 pathogens pathogen NNS cord-339015-qn8wbnlw 127 9 as as RB cord-339015-qn8wbnlw 127 10 well well RB cord-339015-qn8wbnlw 127 11 as as IN cord-339015-qn8wbnlw 127 12 drug drug NN cord-339015-qn8wbnlw 127 13 resistance resistance NN cord-339015-qn8wbnlw 127 14 involving involve VBG cord-339015-qn8wbnlw 127 15 Enterobacteriaceae Enterobacteriaceae NNP cord-339015-qn8wbnlw 127 16 species specie NNS cord-339015-qn8wbnlw 127 17 , , , cord-339015-qn8wbnlw 127 18 Acinetobacter Acinetobacter NNP cord-339015-qn8wbnlw 127 19 baumannii baumannii NNP cord-339015-qn8wbnlw 127 20 , , , cord-339015-qn8wbnlw 127 21 and and CC cord-339015-qn8wbnlw 127 22 Pseudomonas Pseudomonas NNP cord-339015-qn8wbnlw 127 23 should should MD cord-339015-qn8wbnlw 127 24 be be VB cord-339015-qn8wbnlw 127 25 considered consider VBN cord-339015-qn8wbnlw 127 26 a a DT cord-339015-qn8wbnlw 127 27 major major JJ cord-339015-qn8wbnlw 127 28 threat threat NN cord-339015-qn8wbnlw 127 29 to to IN cord-339015-qn8wbnlw 127 30 public public JJ cord-339015-qn8wbnlw 127 31 health health NN cord-339015-qn8wbnlw 127 32 . . . cord-339015-qn8wbnlw 128 1 There there EX cord-339015-qn8wbnlw 128 2 is be VBZ cord-339015-qn8wbnlw 128 3 a a DT cord-339015-qn8wbnlw 128 4 need need NN cord-339015-qn8wbnlw 128 5 for for IN cord-339015-qn8wbnlw 128 6 the the DT cord-339015-qn8wbnlw 128 7 development development NN cord-339015-qn8wbnlw 128 8 of of IN cord-339015-qn8wbnlw 128 9 new new JJ cord-339015-qn8wbnlw 128 10 and and CC cord-339015-qn8wbnlw 128 11 more more RBR cord-339015-qn8wbnlw 128 12 effective effective JJ cord-339015-qn8wbnlw 128 13 drugs drug NNS cord-339015-qn8wbnlw 128 14 . . . cord-339015-qn8wbnlw 129 1 Vaccinations vaccination NNS cord-339015-qn8wbnlw 129 2 and and CC cord-339015-qn8wbnlw 129 3 effective effective JJ cord-339015-qn8wbnlw 129 4 infection infection NN cord-339015-qn8wbnlw 129 5 control control NN cord-339015-qn8wbnlw 129 6 practice practice NN cord-339015-qn8wbnlw 129 7 should should MD cord-339015-qn8wbnlw 129 8 be be VB cord-339015-qn8wbnlw 129 9 emphasized emphasize VBN cord-339015-qn8wbnlw 129 10 globally globally RB cord-339015-qn8wbnlw 129 11 . . . cord-339015-qn8wbnlw 130 1 International international JJ cord-339015-qn8wbnlw 130 2 study study NN cord-339015-qn8wbnlw 130 3 of of IN cord-339015-qn8wbnlw 130 4 the the DT cord-339015-qn8wbnlw 130 5 prevalence prevalence NN cord-339015-qn8wbnlw 130 6 and and CC cord-339015-qn8wbnlw 130 7 outcomes outcome NNS cord-339015-qn8wbnlw 130 8 of of IN cord-339015-qn8wbnlw 130 9 infection infection NN cord-339015-qn8wbnlw 130 10 in in IN cord-339015-qn8wbnlw 130 11 intensive intensive JJ cord-339015-qn8wbnlw 130 12 care care NN cord-339015-qn8wbnlw 130 13 units unit NNS cord-339015-qn8wbnlw 130 14 Device device NN cord-339015-qn8wbnlw 130 15 - - HYPH cord-339015-qn8wbnlw 130 16 associated associate VBN cord-339015-qn8wbnlw 130 17 nosocomial nosocomial JJ cord-339015-qn8wbnlw 130 18 infection infection NN cord-339015-qn8wbnlw 130 19 rates rate NNS cord-339015-qn8wbnlw 130 20 in in IN cord-339015-qn8wbnlw 130 21 intensive intensive JJ cord-339015-qn8wbnlw 130 22 care care NN cord-339015-qn8wbnlw 130 23 units unit NNS cord-339015-qn8wbnlw 130 24 at at IN cord-339015-qn8wbnlw 130 25 Cairo Cairo NNP cord-339015-qn8wbnlw 130 26 University University NNP cord-339015-qn8wbnlw 130 27 hospitals hospital NNS cord-339015-qn8wbnlw 130 28 : : : cord-339015-qn8wbnlw 131 1 first first JJ cord-339015-qn8wbnlw 131 2 step step NN cord-339015-qn8wbnlw 131 3 toward toward IN cord-339015-qn8wbnlw 131 4 initiating initiate VBG cord-339015-qn8wbnlw 131 5 surveillance surveillance NN cord-339015-qn8wbnlw 131 6 programs program NNS cord-339015-qn8wbnlw 131 7 in in IN cord-339015-qn8wbnlw 131 8 a a DT cord-339015-qn8wbnlw 131 9 resource resource NN cord-339015-qn8wbnlw 131 10 - - HYPH cord-339015-qn8wbnlw 131 11 limited limit VBN cord-339015-qn8wbnlw 131 12 country country NN cord-339015-qn8wbnlw 132 1 The the DT cord-339015-qn8wbnlw 132 2 Washington Washington NNP cord-339015-qn8wbnlw 132 3 manual manual NN cord-339015-qn8wbnlw 132 4 of of IN cord-339015-qn8wbnlw 132 5 critical critical JJ cord-339015-qn8wbnlw 132 6 care care NN cord-339015-qn8wbnlw 132 7 Critical Critical NNP cord-339015-qn8wbnlw 132 8 care care NN cord-339015-qn8wbnlw 132 9 medicine medicine NN cord-339015-qn8wbnlw 132 10 e e NN cord-339015-qn8wbnlw 132 11 - - NN cord-339015-qn8wbnlw 132 12 book book NN cord-339015-qn8wbnlw 132 13 : : : cord-339015-qn8wbnlw 132 14 principles principle NNS cord-339015-qn8wbnlw 132 15 of of IN cord-339015-qn8wbnlw 132 16 diagnosis diagnosis NN cord-339015-qn8wbnlw 132 17 and and CC cord-339015-qn8wbnlw 132 18 management management NN cord-339015-qn8wbnlw 132 19 in in IN cord-339015-qn8wbnlw 132 20 the the DT cord-339015-qn8wbnlw 132 21 adult adult NN cord-339015-qn8wbnlw 132 22 Comparison comparison NN cord-339015-qn8wbnlw 132 23 of of IN cord-339015-qn8wbnlw 132 24 8 8 CD cord-339015-qn8wbnlw 132 25 vs vs IN cord-339015-qn8wbnlw 132 26 15 15 CD cord-339015-qn8wbnlw 132 27 days day NNS cord-339015-qn8wbnlw 132 28 of of IN cord-339015-qn8wbnlw 132 29 antibiotic antibiotic JJ cord-339015-qn8wbnlw 132 30 therapy therapy NN cord-339015-qn8wbnlw 132 31 for for IN cord-339015-qn8wbnlw 132 32 ventilator ventilator NN cord-339015-qn8wbnlw 132 33 - - HYPH cord-339015-qn8wbnlw 132 34 associated associate VBN cord-339015-qn8wbnlw 132 35 pneumonia pneumonia NN cord-339015-qn8wbnlw 132 36 in in IN cord-339015-qn8wbnlw 132 37 adults adult NNS cord-339015-qn8wbnlw 132 38 : : : cord-339015-qn8wbnlw 132 39 a a DT cord-339015-qn8wbnlw 132 40 randomized randomized JJ cord-339015-qn8wbnlw 132 41 trial trial NN cord-339015-qn8wbnlw 132 42 Infection infection NN cord-339015-qn8wbnlw 132 43 in in IN cord-339015-qn8wbnlw 132 44 solid solid JJ cord-339015-qn8wbnlw 132 45 - - HYPH cord-339015-qn8wbnlw 132 46 organ organ NN cord-339015-qn8wbnlw 132 47 transplant transplant NN cord-339015-qn8wbnlw 132 48 recipients recipient NNS cord-339015-qn8wbnlw 133 1 Nosocomial nosocomial JJ cord-339015-qn8wbnlw 133 2 infections infection NNS cord-339015-qn8wbnlw 133 3 among among IN cord-339015-qn8wbnlw 133 4 neonates neonate NNS cord-339015-qn8wbnlw 133 5 in in IN cord-339015-qn8wbnlw 133 6 high high JJ cord-339015-qn8wbnlw 133 7 - - HYPH cord-339015-qn8wbnlw 133 8 risk risk NN cord-339015-qn8wbnlw 133 9 nurseries nursery NNS cord-339015-qn8wbnlw 133 10 in in IN cord-339015-qn8wbnlw 133 11 the the DT cord-339015-qn8wbnlw 133 12 United United NNP cord-339015-qn8wbnlw 133 13 States States NNP cord-339015-qn8wbnlw 133 14 . . . cord-339015-qn8wbnlw 134 1 National National NNP cord-339015-qn8wbnlw 134 2 Nosocomial Nosocomial NNP cord-339015-qn8wbnlw 134 3 Infections Infections NNPS cord-339015-qn8wbnlw 134 4 Surveillance Surveillance NNP cord-339015-qn8wbnlw 134 5 System System NNP cord-339015-qn8wbnlw 134 6 Lumbar lumbar JJ cord-339015-qn8wbnlw 134 7 puncture puncture NN cord-339015-qn8wbnlw 134 8 in in IN cord-339015-qn8wbnlw 134 9 pediatric pediatric JJ cord-339015-qn8wbnlw 134 10 bacterial bacterial JJ cord-339015-qn8wbnlw 134 11 meningitis meningitis NN cord-339015-qn8wbnlw 134 12 : : : cord-339015-qn8wbnlw 134 13 defining define VBG cord-339015-qn8wbnlw 134 14 the the DT cord-339015-qn8wbnlw 134 15 time time NN cord-339015-qn8wbnlw 134 16 interval interval NN cord-339015-qn8wbnlw 134 17 for for IN cord-339015-qn8wbnlw 134 18 recovery recovery NN cord-339015-qn8wbnlw 134 19 of of IN cord-339015-qn8wbnlw 134 20 cerebrospinal cerebrospinal JJ cord-339015-qn8wbnlw 134 21 fluid fluid JJ cord-339015-qn8wbnlw 134 22 pathogens pathogen NNS cord-339015-qn8wbnlw 134 23 after after IN cord-339015-qn8wbnlw 134 24 parenteral parenteral JJ cord-339015-qn8wbnlw 134 25 antibiotic antibiotic JJ cord-339015-qn8wbnlw 134 26 pretreatment pretreatment NN cord-339015-qn8wbnlw 134 27 The the DT cord-339015-qn8wbnlw 134 28 high high JJ cord-339015-qn8wbnlw 134 29 cost cost NN cord-339015-qn8wbnlw 134 30 of of IN cord-339015-qn8wbnlw 134 31 acute acute JJ cord-339015-qn8wbnlw 134 32 health health NN cord-339015-qn8wbnlw 134 33 care care NN cord-339015-qn8wbnlw 134 34 : : : cord-339015-qn8wbnlw 134 35 a a DT cord-339015-qn8wbnlw 134 36 review review NN cord-339015-qn8wbnlw 134 37 of of IN cord-339015-qn8wbnlw 134 38 escalating escalate VBG cord-339015-qn8wbnlw 134 39 costs cost NNS cord-339015-qn8wbnlw 134 40 and and CC cord-339015-qn8wbnlw 134 41 limitations limitation NNS cord-339015-qn8wbnlw 134 42 of of IN cord-339015-qn8wbnlw 134 43 such such JJ cord-339015-qn8wbnlw 134 44 exposure exposure NN cord-339015-qn8wbnlw 134 45 in in IN cord-339015-qn8wbnlw 134 46 intensive intensive JJ cord-339015-qn8wbnlw 134 47 care care NN cord-339015-qn8wbnlw 134 48 units unit NNS cord-339015-qn8wbnlw 134 49 Antibiotics antibiotic NNS cord-339015-qn8wbnlw 134 50 and and CC cord-339015-qn8wbnlw 134 51 bacterial bacterial JJ cord-339015-qn8wbnlw 134 52 resistance resistance NN cord-339015-qn8wbnlw 134 53 in in IN cord-339015-qn8wbnlw 134 54 the the DT cord-339015-qn8wbnlw 134 55 21st 21st JJ cord-339015-qn8wbnlw 134 56 century century NN cord-339015-qn8wbnlw 135 1 The the DT cord-339015-qn8wbnlw 135 2 surviving survive VBG cord-339015-qn8wbnlw 135 3 sepsis sepsis NN cord-339015-qn8wbnlw 135 4 campaign campaign NN cord-339015-qn8wbnlw 135 5 bundle bundle NN cord-339015-qn8wbnlw 135 6 : : : cord-339015-qn8wbnlw 135 7 2018 2018 CD cord-339015-qn8wbnlw 135 8 update update NN