id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-313980-jutof78v	van de Veerdonk, F. L.	A systems approach to inflammation identifies therapeutic targets in SARS-CoV-2 infection	2020-05-24		.txt	text/plain	4683	271	49	Inflammation plays a central role in the pathogenesis of ARDS and circulating concentrations of proinflammatory cytokines such as interleukin (IL)-6, tumour necrosis factor (TNF)-α, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1α and interferon- inducible protein (IP)-10 are higher in COVID-19 patients on the intensive care unit (ICU) than in those who do not require ICU admission. 23.20110916 doi: medRxiv preprint Whereas from these data an exuberant innate immune response appears to represent the main immune dysregulation in patients with severe COVID-19 infection, so far only a limited number of inflammatory mediators known to be involved in other diseases have been assessed. 23.20110916 doi: medRxiv preprint In addition to the inflammatory factors that are upregulated in COVID-19 patients in the ICU, a number of cytokines were shown to be lower in the severely ill patients. However, unbiased clustering of COVID-19 patients differentiated patients based on disease severity (ICU versus non ICU), rather than identifying different inflammatory clusters ( Figure 2 ).	./cache/cord-313980-jutof78v.txt	./txt/cord-313980-jutof78v.txt