id author title date pages extension mime words sentences flesch summary cache txt cord-305074-wz17u4e7 Fernandez, Javier Plasma Exchange: An Effective Rescue Therapy in Critically Ill Patients With Coronavirus Disease 2019 Infection 2020-08-24 .txt text/plain 2655 187 45 CONCLUSIONS: Plasma exchange mitigates cytokine storm, reverses organ failure, and could improve survival in critically ill patients with coronavirus disease 2019 infection. We report a case series of four critically ill patients infected by severe acute respiratory syndrome coronavirus 2 www.ccmjournal.org XXX 2020 • Volume XX • Number XXX (SARS-CoV-2) successfully treated with plasma exchange. Upon suspicion of hyperinflammatory state due to cytokine storm and macrophage activation like syndrome, therapeutic plasma exchange was started on day 10. The patient condition improved in the following days: fever resolved 3 days following the fourth session of plasma exchange (day 19), renal, cardiac, and respiratory function normalized, and laboratory findings showed sustained improvement ( Fig. 1 Table 2 , Supplemental Digital Content 3, http://links.lww.com/CCM/F805). Fever resolved, cardiac and renal function normalized in few days, and regular laboratory tests ( Fig. 1 Table 2 , Supplemental Digital Content 3, http://links.lww.com/CCM/F805) and plasma cytokines also improved (Fig. 2) . ./cache/cord-305074-wz17u4e7.txt ./txt/cord-305074-wz17u4e7.txt