id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253695-tjdw2uta	Winter, Christine	Infection of the tracheal epithelium by infectious bronchitis virus is sialic acid dependent	2007-12-28		.txt	text/plain	3679	208	52	Avian Infectious bronchitis virus (IBV) is a coronavirus that infects chickens via the respiratory epithelium as primary target cells. Here we analyze the importance of the sialic acid binding activity for the infection of tracheal organ cultures (TOCs) by different IBV strains. Desialylation induced by neuraminidase treatment of tracheal organ cultures prior to infection by IBV delayed the ciliostatic effect or resulted in partial loss of ciliary activity. After having shown recently that sialic acid serves as a receptor determinant for IBV on cultured cells, we were interested to find out whether this type of sugar is also important for an infection in vivo. From this result we conclude that a2,3-linked sialic acid serves as a receptor determinant for the infection of avian tracheal epithelial cells by the Beaudette strain of IBV. Sialic acid is a receptor determinant for infection of cells by avian Infectious bronchitis virus	./cache/cord-253695-tjdw2uta.txt	./txt/cord-253695-tjdw2uta.txt