id	sid	tid	token	lemma	pos
cord-306325-9alfvda1	1	1	key	key	JJ
cord-306325-9alfvda1	1	2	:	:	:
cord-306325-9alfvda1	1	3	cord-306325	cord-306325	VB
cord-306325-9alfvda1	1	4	-	-	HYPH
cord-306325-9alfvda1	1	5	9alfvda1	9alfvda1	CD
cord-306325-9alfvda1	1	6	authors	author	NNS
cord-306325-9alfvda1	1	7	:	:	:
cord-306325-9alfvda1	1	8	Galmozzi	Galmozzi	NNP
cord-306325-9alfvda1	1	9	,	,	,
cord-306325-9alfvda1	1	10	E.	E.	NNP
cord-306325-9alfvda1	1	11	;	;	:
cord-306325-9alfvda1	1	12	Lampertico	Lampertico	NNP
cord-306325-9alfvda1	1	13	,	,	,
cord-306325-9alfvda1	1	14	P.	P.	NNP
cord-306325-9alfvda1	1	15	title	title	NN
cord-306325-9alfvda1	1	16	:	:	:
cord-306325-9alfvda1	2	1	Letter	letter	NN
cord-306325-9alfvda1	2	2	:	:	:
cord-306325-9alfvda1	2	3	does	do	VBZ
cord-306325-9alfvda1	2	4	the	the	DT
cord-306325-9alfvda1	2	5	IFNL4	IFNL4	NNP
cord-306325-9alfvda1	2	6	gene	gene	NN
cord-306325-9alfvda1	2	7	discovery	discovery	NN
cord-306325-9alfvda1	2	8	really	really	RB
cord-306325-9alfvda1	2	9	provide	provide	VBP
cord-306325-9alfvda1	2	10	a	a	DT
cord-306325-9alfvda1	2	11	causal	causal	JJ
cord-306325-9alfvda1	2	12	role	role	NN
cord-306325-9alfvda1	2	13	for	for	IN
cord-306325-9alfvda1	2	14	the	the	DT
cord-306325-9alfvda1	2	15	IL28B	IL28B	NNP
cord-306325-9alfvda1	2	16	haplotype	haplotype	NN
cord-306325-9alfvda1	2	17	blocks	block	NNS
cord-306325-9alfvda1	2	18	?	?	.
cord-306325-9alfvda1	3	1	date	date	NN
cord-306325-9alfvda1	3	2	:	:	:
cord-306325-9alfvda1	4	1	2014	2014	CD
cord-306325-9alfvda1	4	2	-	-	HYPH
cord-306325-9alfvda1	4	3	02	02	CD
cord-306325-9alfvda1	4	4	-	-	HYPH
cord-306325-9alfvda1	4	5	04	04	CD
cord-306325-9alfvda1	4	6	journal	journal	NN
cord-306325-9alfvda1	4	7	:	:	:
cord-306325-9alfvda1	5	1	Aliment	Aliment	NNP
cord-306325-9alfvda1	5	2	Pharmacol	Pharmacol	NNP
cord-306325-9alfvda1	6	1	Ther	ther	JJ
cord-306325-9alfvda1	6	2	DOI	DOI	NNP
cord-306325-9alfvda1	6	3	:	:	:
cord-306325-9alfvda1	7	1	10.1111	10.1111	CD
cord-306325-9alfvda1	7	2	/	/	SYM
cord-306325-9alfvda1	7	3	apt.12615	apt.12615	NN
cord-306325-9alfvda1	8	1	sha	sha	NNP
cord-306325-9alfvda1	8	2	:	:	:
cord-306325-9alfvda1	9	1	46ed9a3bd52df1dbb27d6b4d3bb3064a48d6fedf	46ed9a3bd52df1dbb27d6b4d3bb3064a48d6fedf	CD
cord-306325-9alfvda1	9	2	doc_id	doc_id	CD
cord-306325-9alfvda1	9	3	:	:	:
cord-306325-9alfvda1	10	1	306325	306325	CD
cord-306325-9alfvda1	10	2	cord_uid	cord_uid	NNS
cord-306325-9alfvda1	10	3	:	:	:
cord-306325-9alfvda1	10	4	9alfvda1	9alfvda1	CD
cord-306325-9alfvda1	11	1	nan	nan	NNP
cord-306325-9alfvda1	11	2	SIRS	SIRS	NNP
cord-306325-9alfvda1	11	3	,	,	,
cord-306325-9alfvda1	11	4	We	-PRON-	PRP
cord-306325-9alfvda1	11	5	read	read	VBP
cord-306325-9alfvda1	11	6	with	with	IN
cord-306325-9alfvda1	11	7	great	great	JJ
cord-306325-9alfvda1	11	8	interest	interest	NN
cord-306325-9alfvda1	11	9	the	the	DT
cord-306325-9alfvda1	11	10	comprehensive	comprehensive	JJ
cord-306325-9alfvda1	11	11	review	review	NN
cord-306325-9alfvda1	11	12	study	study	NN
cord-306325-9alfvda1	11	13	of	of	IN
cord-306325-9alfvda1	11	14	Mouli	Mouli	NNP
cord-306325-9alfvda1	11	15	and	and	CC
cord-306325-9alfvda1	11	16	Ananthakrishnan	Ananthakrishnan	NNP
cord-306325-9alfvda1	11	17	.	.	.
cord-306325-9alfvda1	12	1	1	1	LS
cord-306325-9alfvda1	13	1	The	the	DT
cord-306325-9alfvda1	13	2	authors	author	NNS
cord-306325-9alfvda1	13	3	have	have	VBP
cord-306325-9alfvda1	13	4	evaluated	evaluate	VBN
cord-306325-9alfvda1	13	5	and	and	CC
cord-306325-9alfvda1	13	6	discussed	discuss	VBN
cord-306325-9alfvda1	13	7	current	current	JJ
cord-306325-9alfvda1	13	8	evidence	evidence	NN
cord-306325-9alfvda1	13	9	regarding	regard	VBG
cord-306325-9alfvda1	13	10	the	the	DT
cord-306325-9alfvda1	13	11	roles	role	NNS
cord-306325-9alfvda1	13	12	of	of	IN
cord-306325-9alfvda1	13	13	vitamin	vitamin	NN
cord-306325-9alfvda1	13	14	D	d	NN
cord-306325-9alfvda1	13	15	deficiency	deficiency	NN
cord-306325-9alfvda1	13	16	in	in	IN
cord-306325-9alfvda1	13	17	the	the	DT
cord-306325-9alfvda1	13	18	pathogenesis	pathogenesis	NN
cord-306325-9alfvda1	13	19	and	and	CC
cord-306325-9alfvda1	13	20	progression	progression	NN
cord-306325-9alfvda1	13	21	of	of	IN
cord-306325-9alfvda1	13	22	inflammatory	inflammatory	JJ
cord-306325-9alfvda1	13	23	bowel	bowel	NN
cord-306325-9alfvda1	13	24	disease	disease	NN
cord-306325-9alfvda1	13	25	(	(	-LRB-
cord-306325-9alfvda1	13	26	IBD	IBD	NNP
cord-306325-9alfvda1	13	27	)	)	-RRB-
cord-306325-9alfvda1	13	28	.	.	.
cord-306325-9alfvda1	14	1	In	in	IN
cord-306325-9alfvda1	14	2	this	this	DT
cord-306325-9alfvda1	14	3	regard	regard	NN
cord-306325-9alfvda1	14	4	,	,	,
cord-306325-9alfvda1	14	5	different	different	JJ
cord-306325-9alfvda1	14	6	cellular	cellular	JJ
cord-306325-9alfvda1	14	7	and	and	CC
cord-306325-9alfvda1	14	8	molecular	molecular	JJ
cord-306325-9alfvda1	14	9	mechanisms	mechanism	NNS
cord-306325-9alfvda1	14	10	are	be	VBP
cord-306325-9alfvda1	14	11	discussed	discuss	VBN
cord-306325-9alfvda1	14	12	in	in	IN
cord-306325-9alfvda1	14	13	this	this	DT
cord-306325-9alfvda1	14	14	review	review	NN
cord-306325-9alfvda1	14	15	.	.	.
cord-306325-9alfvda1	15	1	However	however	RB
cord-306325-9alfvda1	15	2	,	,	,
cord-306325-9alfvda1	15	3	as	as	IN
cord-306325-9alfvda1	15	4	mentioned	mention	VBN
cord-306325-9alfvda1	15	5	by	by	IN
cord-306325-9alfvda1	15	6	the	the	DT
cord-306325-9alfvda1	15	7	authors	author	NNS
cord-306325-9alfvda1	15	8	,	,	,
cord-306325-9alfvda1	15	9	there	there	EX
cord-306325-9alfvda1	15	10	is	be	VBZ
cord-306325-9alfvda1	15	11	a	a	DT
cord-306325-9alfvda1	15	12	strong	strong	JJ
cord-306325-9alfvda1	15	13	role	role	NN
cord-306325-9alfvda1	15	14	for	for	IN
cord-306325-9alfvda1	15	15	environmental	environmental	JJ
cord-306325-9alfvda1	15	16	factors	factor	NNS
cord-306325-9alfvda1	15	17	in	in	IN
cord-306325-9alfvda1	15	18	the	the	DT
cord-306325-9alfvda1	15	19	pathogenesis	pathogenesis	NN
cord-306325-9alfvda1	15	20	and	and	CC
cord-306325-9alfvda1	15	21	progression	progression	NN
cord-306325-9alfvda1	15	22	of	of	IN
cord-306325-9alfvda1	15	23	IBD	IBD	NNP
cord-306325-9alfvda1	15	24	.	.	.
cord-306325-9alfvda1	16	1	There	there	EX
cord-306325-9alfvda1	16	2	is	be	VBZ
cord-306325-9alfvda1	16	3	growing	grow	VBG
cord-306325-9alfvda1	16	4	evidence	evidence	NN
cord-306325-9alfvda1	16	5	that	that	IN
cord-306325-9alfvda1	16	6	psychological	psychological	JJ
cord-306325-9alfvda1	16	7	factors	factor	NNS
cord-306325-9alfvda1	16	8	,	,	,
cord-306325-9alfvda1	16	9	including	include	VBG
cord-306325-9alfvda1	16	10	psychological	psychological	JJ
cord-306325-9alfvda1	16	11	stress	stress	NN
cord-306325-9alfvda1	16	12	and	and	CC
cord-306325-9alfvda1	16	13	depression	depression	NN
cord-306325-9alfvda1	16	14	,	,	,
cord-306325-9alfvda1	16	15	are	be	VBP
cord-306325-9alfvda1	16	16	influential	influential	JJ
cord-306325-9alfvda1	16	17	in	in	IN
cord-306325-9alfvda1	16	18	the	the	DT
cord-306325-9alfvda1	16	19	pathogenesis	pathogenesis	NN
cord-306325-9alfvda1	16	20	and	and	CC
cord-306325-9alfvda1	16	21	clinical	clinical	JJ
cord-306325-9alfvda1	16	22	course	course	NN
cord-306325-9alfvda1	16	23	of	of	IN
cord-306325-9alfvda1	16	24	IBD	IBD	NNP
cord-306325-9alfvda1	16	25	.	.	.
cord-306325-9alfvda1	17	1	2	2	LS
cord-306325-9alfvda1	17	2	,	,	,
cord-306325-9alfvda1	17	3	3	3	CD
cord-306325-9alfvda1	17	4	Growing	grow	VBG
cord-306325-9alfvda1	17	5	evidence	evidence	NN
cord-306325-9alfvda1	17	6	also	also	RB
cord-306325-9alfvda1	17	7	indicates	indicate	VBZ
cord-306325-9alfvda1	17	8	the	the	DT
cord-306325-9alfvda1	17	9	importance	importance	NN
cord-306325-9alfvda1	17	10	of	of	IN
cord-306325-9alfvda1	17	11	sleep	sleep	NN
cord-306325-9alfvda1	17	12	disorders	disorder	NNS
cord-306325-9alfvda1	17	13	in	in	IN
cord-306325-9alfvda1	17	14	the	the	DT
cord-306325-9alfvda1	17	15	clinical	clinical	JJ
cord-306325-9alfvda1	17	16	course	course	NN
cord-306325-9alfvda1	17	17	of	of	IN
cord-306325-9alfvda1	17	18	IBD	IBD	NNP
cord-306325-9alfvda1	17	19	.	.	.
cord-306325-9alfvda1	18	1	It	-PRON-	PRP
cord-306325-9alfvda1	18	2	has	have	VBZ
cord-306325-9alfvda1	18	3	been	be	VBN
cord-306325-9alfvda1	18	4	shown	show	VBN
cord-306325-9alfvda1	18	5	that	that	IN
cord-306325-9alfvda1	18	6	sleep	sleep	NN
cord-306325-9alfvda1	18	7	disturbance	disturbance	NN
cord-306325-9alfvda1	18	8	increases	increase	VBZ
cord-306325-9alfvda1	18	9	the	the	DT
cord-306325-9alfvda1	18	10	risk	risk	NN
cord-306325-9alfvda1	18	11	of	of	IN
cord-306325-9alfvda1	18	12	disease	disease	NN
cord-306325-9alfvda1	18	13	flares	flare	NNS
cord-306325-9alfvda1	18	14	in	in	IN
cord-306325-9alfvda1	18	15	patients	patient	NNS
cord-306325-9alfvda1	18	16	.	.	.
cord-306325-9alfvda1	19	1	[	[	-LRB-
cord-306325-9alfvda1	19	2	4	4	CD
cord-306325-9alfvda1	19	3	]	]	-RRB-
cord-306325-9alfvda1	19	4	[	[	-LRB-
cord-306325-9alfvda1	19	5	5	5	CD
cord-306325-9alfvda1	19	6	]	]	-RRB-
cord-306325-9alfvda1	20	1	[	[	-LRB-
cord-306325-9alfvda1	20	2	6	6	CD
cord-306325-9alfvda1	20	3	]	]	-RRB-
cord-306325-9alfvda1	21	1	It	-PRON-	PRP
cord-306325-9alfvda1	21	2	is	be	VBZ
cord-306325-9alfvda1	21	3	therefore	therefore	RB
cord-306325-9alfvda1	21	4	interesting	interesting	JJ
cord-306325-9alfvda1	21	5	that	that	IN
cord-306325-9alfvda1	21	6	vitamin	vitamin	NN
cord-306325-9alfvda1	21	7	D	D	NNP
cord-306325-9alfvda1	21	8	deficiency	deficiency	NN
cord-306325-9alfvda1	21	9	has	have	VBZ
cord-306325-9alfvda1	21	10	been	be	VBN
cord-306325-9alfvda1	21	11	shown	show	VBN
cord-306325-9alfvda1	21	12	to	to	TO
cord-306325-9alfvda1	21	13	play	play	VB
cord-306325-9alfvda1	21	14	a	a	DT
cord-306325-9alfvda1	21	15	role	role	NN
cord-306325-9alfvda1	21	16	in	in	IN
cord-306325-9alfvda1	21	17	both	both	CC
cord-306325-9alfvda1	21	18	psychological	psychological	JJ
cord-306325-9alfvda1	21	19	7	7	CD
cord-306325-9alfvda1	21	20	and	and	CC
cord-306325-9alfvda1	21	21	sleep	sleep	NN
cord-306325-9alfvda1	21	22	disorders	disorder	NNS
cord-306325-9alfvda1	21	23	8	8	CD
cord-306325-9alfvda1	21	24	in	in	IN
cord-306325-9alfvda1	21	25	non	non	JJ
cord-306325-9alfvda1	21	26	-	-	JJ
cord-306325-9alfvda1	21	27	IBD	ibd	JJ
cord-306325-9alfvda1	21	28	populations	population	NNS
cord-306325-9alfvda1	21	29	,	,	,
cord-306325-9alfvda1	21	30	although	although	IN
cord-306325-9alfvda1	21	31	the	the	DT
cord-306325-9alfvda1	21	32	underlying	underlie	VBG
cord-306325-9alfvda1	21	33	mechanisms	mechanism	NNS
cord-306325-9alfvda1	21	34	are	be	VBP
cord-306325-9alfvda1	21	35	still	still	RB
cord-306325-9alfvda1	21	36	unknown	unknown	JJ
cord-306325-9alfvda1	21	37	.	.	.
cord-306325-9alfvda1	22	1	There	there	EX
cord-306325-9alfvda1	22	2	is	be	VBZ
cord-306325-9alfvda1	22	3	no	no	DT
cord-306325-9alfvda1	22	4	study	study	NN
cord-306325-9alfvda1	22	5	till	till	IN
cord-306325-9alfvda1	22	6	now	now	RB
cord-306325-9alfvda1	22	7	evaluating	evaluate	VBG
cord-306325-9alfvda1	22	8	the	the	DT
cord-306325-9alfvda1	22	9	effects	effect	NNS
cord-306325-9alfvda1	22	10	of	of	IN
cord-306325-9alfvda1	22	11	vitamin	vitamin	NN
cord-306325-9alfvda1	22	12	D	d	NN
cord-306325-9alfvda1	22	13	deficiency	deficiency	NN
cord-306325-9alfvda1	22	14	on	on	IN
cord-306325-9alfvda1	22	15	psychological	psychological	JJ
cord-306325-9alfvda1	22	16	health	health	NN
cord-306325-9alfvda1	22	17	or	or	CC
cord-306325-9alfvda1	22	18	sleep	sleep	NN
cord-306325-9alfvda1	22	19	quality	quality	NN
cord-306325-9alfvda1	22	20	in	in	IN
cord-306325-9alfvda1	22	21	IBD	IBD	NNP
cord-306325-9alfvda1	22	22	patients	patient	NNS
cord-306325-9alfvda1	22	23	.	.	.
cord-306325-9alfvda1	23	1	Although	although	IN
cord-306325-9alfvda1	23	2	several	several	JJ
cord-306325-9alfvda1	23	3	factors	factor	NNS
cord-306325-9alfvda1	23	4	can	can	MD
cord-306325-9alfvda1	23	5	affect	affect	VB
cord-306325-9alfvda1	23	6	psycho	psycho	JJ
cord-306325-9alfvda1	23	7	-	-	HYPH
cord-306325-9alfvda1	23	8	logical	logical	JJ
cord-306325-9alfvda1	23	9	health	health	NN
cord-306325-9alfvda1	23	10	and	and	CC
cord-306325-9alfvda1	23	11	sleep	sleep	NN
cord-306325-9alfvda1	23	12	quality	quality	NN
cord-306325-9alfvda1	23	13	in	in	IN
cord-306325-9alfvda1	23	14	IBD	IBD	NNP
cord-306325-9alfvda1	23	15	patients	patient	NNS
cord-306325-9alfvda1	23	16	including	include	VBG
cord-306325-9alfvda1	23	17	demographic	demographic	JJ
cord-306325-9alfvda1	23	18	-	-	HYPH
cord-306325-9alfvda1	23	19	and	and	CC
cord-306325-9alfvda1	23	20	disease	disease	NN
cord-306325-9alfvda1	23	21	-	-	HYPH
cord-306325-9alfvda1	23	22	related	relate	VBN
cord-306325-9alfvda1	23	23	factors	factor	NNS
cord-306325-9alfvda1	23	24	,	,	,
cord-306325-9alfvda1	23	25	2	2	CD
cord-306325-9alfvda1	23	26	,	,	,
cord-306325-9alfvda1	23	27	4	4	CD
cord-306325-9alfvda1	23	28	a	a	DT
cord-306325-9alfvda1	23	29	role	role	NN
cord-306325-9alfvda1	23	30	for	for	IN
cord-306325-9alfvda1	23	31	vitamin	vitamin	NN
cord-306325-9alfvda1	23	32	D	D	NNP
cord-306325-9alfvda1	23	33	deficiency	deficiency	NN
cord-306325-9alfvda1	23	34	is	be	VBZ
cord-306325-9alfvda1	23	35	also	also	RB
cord-306325-9alfvda1	23	36	plausible	plausible	JJ
cord-306325-9alfvda1	23	37	.	.	.
cord-306325-9alfvda1	24	1	Therefore	therefore	RB
cord-306325-9alfvda1	24	2	,	,	,
cord-306325-9alfvda1	24	3	the	the	DT
cord-306325-9alfvda1	24	4	'	'	``
cord-306325-9alfvda1	24	5	optimal	optimal	JJ
cord-306325-9alfvda1	24	6	role	role	NN
cord-306325-9alfvda1	24	7	of	of	IN
cord-306325-9alfvda1	24	8	vitamin	vitamin	NN
cord-306325-9alfvda1	24	9	D	d	NN
cord-306325-9alfvda1	24	10	supplementation	supplementation	NN
cord-306325-9alfvda1	24	11	as	as	IN
cord-306325-9alfvda1	24	12	a	a	DT
cord-306325-9alfvda1	24	13	therapeutic	therapeutic	JJ
cord-306325-9alfvda1	24	14	modality	modality	NN
cord-306325-9alfvda1	24	15	in	in	IN
cord-306325-9alfvda1	24	16	patients	patient	NNS
cord-306325-9alfvda1	24	17	with	with	IN
cord-306325-9alfvda1	24	18	IBD	IBD	NNP
cord-306325-9alfvda1	24	19	'	'	POS
cord-306325-9alfvda1	24	20	is	be	VBZ
cord-306325-9alfvda1	24	21	not	not	RB
cord-306325-9alfvda1	24	22	only	only	RB
cord-306325-9alfvda1	24	23	the	the	DT
cord-306325-9alfvda1	24	24	induction	induction	NN
cord-306325-9alfvda1	24	25	and	and	CC
cord-306325-9alfvda1	24	26	maintenance	maintenance	NN
cord-306325-9alfvda1	24	27	of	of	IN
cord-306325-9alfvda1	24	28	remission	remission	NN
cord-306325-9alfvda1	24	29	as	as	IN
cord-306325-9alfvda1	24	30	mentioned	mention	VBN
cord-306325-9alfvda1	24	31	by	by	IN
cord-306325-9alfvda1	24	32	Mouli	Mouli	NNP
cord-306325-9alfvda1	24	33	and	and	CC
cord-306325-9alfvda1	24	34	Ananthakrishnan	Ananthakrishnan	NNP
cord-306325-9alfvda1	24	35	1	1	CD
cord-306325-9alfvda1	25	1	but	but	CC
cord-306325-9alfvda1	25	2	may	may	MD
cord-306325-9alfvda1	25	3	also	also	RB
cord-306325-9alfvda1	25	4	include	include	VB
cord-306325-9alfvda1	25	5	treatment	treatment	NN
cord-306325-9alfvda1	25	6	of	of	IN
cord-306325-9alfvda1	25	7	psychological	psychological	JJ
cord-306325-9alfvda1	25	8	and	and	CC
cord-306325-9alfvda1	25	9	sleep	sleep	NN
cord-306325-9alfvda1	25	10	disorders	disorder	NNS
cord-306325-9alfvda1	25	11	in	in	IN
cord-306325-9alfvda1	25	12	IBD	IBD	NNP
cord-306325-9alfvda1	25	13	patients	patient	NNS
cord-306325-9alfvda1	25	14	.	.	.
cord-306325-9alfvda1	26	1	These	these	DT
cord-306325-9alfvda1	26	2	issues	issue	NNS
cord-306325-9alfvda1	26	3	should	should	MD
cord-306325-9alfvda1	26	4	be	be	VB
cord-306325-9alfvda1	26	5	added	add	VBN
cord-306325-9alfvda1	26	6	to	to	IN
cord-306325-9alfvda1	26	7	the	the	DT
cord-306325-9alfvda1	26	8	remaining	remain	VBG
cord-306325-9alfvda1	26	9	unanswered	unanswered	JJ
cord-306325-9alfvda1	26	10	questions	question	NNS
cord-306325-9alfvda1	26	11	regarding	regard	VBG
cord-306325-9alfvda1	26	12	the	the	DT
cord-306325-9alfvda1	26	13	role	role	NN
cord-306325-9alfvda1	26	14	of	of	IN
cord-306325-9alfvda1	26	15	vitamin	vitamin	NN
cord-306325-9alfvda1	26	16	D	d	NN
cord-306325-9alfvda1	26	17	in	in	IN
cord-306325-9alfvda1	26	18	IBD	IBD	NNP
cord-306325-9alfvda1	26	19	,	,	,
cord-306325-9alfvda1	26	20	and	and	CC
cord-306325-9alfvda1	26	21	warrant	warrant	VB
cord-306325-9alfvda1	26	22	evaluation	evaluation	NN
cord-306325-9alfvda1	26	23	in	in	IN
cord-306325-9alfvda1	26	24	future	future	JJ
cord-306325-9alfvda1	26	25	studies	study	NNS
cord-306325-9alfvda1	26	26	.	.	.
cord-306325-9alfvda1	27	1	Letter	letter	NN
cord-306325-9alfvda1	27	2	:	:	:
cord-306325-9alfvda1	27	3	does	do	VBZ
cord-306325-9alfvda1	27	4	the	the	DT
cord-306325-9alfvda1	27	5	IFNL4	IFNL4	NNP
cord-306325-9alfvda1	27	6	gene	gene	NN
cord-306325-9alfvda1	27	7	discovery	discovery	NN
cord-306325-9alfvda1	27	8	really	really	RB
cord-306325-9alfvda1	27	9	provide	provide	VBP
cord-306325-9alfvda1	27	10	a	a	DT
cord-306325-9alfvda1	27	11	causal	causal	JJ
cord-306325-9alfvda1	27	12	role	role	NN
cord-306325-9alfvda1	27	13	for	for	IN
cord-306325-9alfvda1	27	14	the	the	DT
cord-306325-9alfvda1	27	15	IL28B	IL28B	NNP
cord-306325-9alfvda1	27	16	haplotype	haplotype	NN
cord-306325-9alfvda1	27	17	blocks	block	NNS
cord-306325-9alfvda1	27	18	?	?	.
cord-306325-9alfvda1	28	1	While	while	IN
cord-306325-9alfvda1	28	2	IFNL4	IFNL4	NNP
cord-306325-9alfvda1	28	3	variant	variant	NN
cord-306325-9alfvda1	28	4	was	be	VBD
cord-306325-9alfvda1	28	5	strongly	strongly	RB
cord-306325-9alfvda1	28	6	associated	associate	VBN
cord-306325-9alfvda1	28	7	with	with	IN
cord-306325-9alfvda1	28	8	a	a	DT
cord-306325-9alfvda1	28	9	sustained	sustained	JJ
cord-306325-9alfvda1	28	10	virological	virological	JJ
cord-306325-9alfvda1	28	11	response	response	NN
cord-306325-9alfvda1	28	12	in	in	IN
cord-306325-9alfvda1	28	13	both	both	CC
cord-306325-9alfvda1	28	14	HCV	HCV	NNP
cord-306325-9alfvda1	28	15	genotypes	genotype	NNS
cord-306325-9alfvda1	28	16	1	1	CD
cord-306325-9alfvda1	28	17	and	and	CC
cord-306325-9alfvda1	28	18	4	4	CD
cord-306325-9alfvda1	28	19	,	,	,
cord-306325-9alfvda1	28	20	and	and	CC
cord-306325-9alfvda1	28	21	thus	thus	RB
cord-306325-9alfvda1	28	22	confirmed	confirm	VBD
cord-306325-9alfvda1	28	23	previous	previous	JJ
cord-306325-9alfvda1	28	24	findings	finding	NNS
cord-306325-9alfvda1	28	25	by	by	IN
cord-306325-9alfvda1	28	26	Prokunina	Prokunina	NNP
cord-306325-9alfvda1	28	27	-	-	HYPH
cord-306325-9alfvda1	28	28	Olsson	Olsson	NNP
cord-306325-9alfvda1	28	29	et	et	NNP
cord-306325-9alfvda1	28	30	al	al	NNP
cord-306325-9alfvda1	28	31	.	.	.
cord-306325-9alfvda1	29	1	2	2	CD
cord-306325-9alfvda1	29	2	and	and	CC
cord-306325-9alfvda1	29	3	Bibert	Bibert	NNP
cord-306325-9alfvda1	29	4	et	et	NNP
cord-306325-9alfvda1	29	5	al	al	NNP
cord-306325-9alfvda1	29	6	.	.	.
cord-306325-9alfvda1	30	1	,	,	,
cord-306325-9alfvda1	30	2	3	3	CD
cord-306325-9alfvda1	30	3	the	the	DT
cord-306325-9alfvda1	30	4	study	study	NN
cord-306325-9alfvda1	30	5	confirms	confirm	VBZ
cord-306325-9alfvda1	30	6	a	a	DT
cord-306325-9alfvda1	30	7	strong	strong	JJ
cord-306325-9alfvda1	30	8	linkage	linkage	NN
cord-306325-9alfvda1	30	9	between	between	IN
cord-306325-9alfvda1	30	10	ss469415590	ss469415590	NNP
cord-306325-9alfvda1	30	11	and	and	CC
cord-306325-9alfvda1	30	12	rs12979860	rs12979860	NN
cord-306325-9alfvda1	30	13	variants	variant	NNS
cord-306325-9alfvda1	30	14	(	(	-LRB-
cord-306325-9alfvda1	30	15	q	q	NNP
cord-306325-9alfvda1	30	16	=	=	NNP
cord-306325-9alfvda1	30	17	0.988	0.988	CD
cord-306325-9alfvda1	30	18	)	)	-RRB-
cord-306325-9alfvda1	30	19	compared	compare	VBN
cord-306325-9alfvda1	30	20	with	with	IN
cord-306325-9alfvda1	30	21	the	the	DT
cord-306325-9alfvda1	30	22	modest	modest	JJ
cord-306325-9alfvda1	30	23	correlation	correlation	NN
cord-306325-9alfvda1	30	24	between	between	IN
cord-306325-9alfvda1	30	25	rs8099917	rs8099917	NNP
cord-306325-9alfvda1	30	26	and	and	CC
cord-306325-9alfvda1	30	27	IFNL4	ifnl4	XX
cord-306325-9alfvda1	31	1	(	(	-LRB-
cord-306325-9alfvda1	31	2	q	q	NNP
cord-306325-9alfvda1	31	3	=	=	NNP
cord-306325-9alfvda1	31	4	0.598	0.598	CD
cord-306325-9alfvda1	31	5	)	)	-RRB-
cord-306325-9alfvda1	31	6	.	.	.
cord-306325-9alfvda1	32	1	These	these	DT
cord-306325-9alfvda1	32	2	findings	finding	NNS
cord-306325-9alfvda1	32	3	therefore	therefore	RB
cord-306325-9alfvda1	32	4	do	do	VBP
cord-306325-9alfvda1	32	5	not	not	RB
cord-306325-9alfvda1	32	6	support	support	VB
cord-306325-9alfvda1	32	7	an	an	DT
cord-306325-9alfvda1	32	8	additional	additional	JJ
cord-306325-9alfvda1	32	9	clinical	clinical	JJ
cord-306325-9alfvda1	32	10	benefit	benefit	NN
cord-306325-9alfvda1	32	11	of	of	IN
cord-306325-9alfvda1	32	12	IFNL4	ifnl4	NN
cord-306325-9alfvda1	32	13	in	in	IN
cord-306325-9alfvda1	32	14	the	the	DT
cord-306325-9alfvda1	32	15	prediction	prediction	NN
cord-306325-9alfvda1	32	16	of	of	IN
cord-306325-9alfvda1	32	17	a	a	DT
cord-306325-9alfvda1	32	18	response	response	NN
cord-306325-9alfvda1	32	19	to	to	IN
cord-306325-9alfvda1	32	20	PEG/	PEG/	NNP
cord-306325-9alfvda1	32	21	RBV	RBV	NNP
cord-306325-9alfvda1	32	22	in	in	IN
cord-306325-9alfvda1	32	23	Caucasian	caucasian	JJ
cord-306325-9alfvda1	32	24	patients	patient	NNS
cord-306325-9alfvda1	32	25	.	.	.
cord-306325-9alfvda1	33	1	Recently	recently	RB
cord-306325-9alfvda1	33	2	,	,	,
cord-306325-9alfvda1	33	3	the	the	DT
cord-306325-9alfvda1	33	4	finding	finding	NN
cord-306325-9alfvda1	33	5	that	that	IN
cord-306325-9alfvda1	33	6	recombinant	recombinant	JJ
cord-306325-9alfvda1	33	7	IFNL4	ifnl4	NN
cord-306325-9alfvda1	33	8	protein	protein	NN
cord-306325-9alfvda1	33	9	exerts	exert	VBZ
cord-306325-9alfvda1	33	10	a	a	DT
cord-306325-9alfvda1	33	11	potent	potent	JJ
cord-306325-9alfvda1	33	12	antiviral	antiviral	JJ
cord-306325-9alfvda1	33	13	activity	activity	NN
cord-306325-9alfvda1	33	14	against	against	IN
cord-306325-9alfvda1	33	15	both	both	CC
cord-306325-9alfvda1	33	16	HCV	HCV	NNP
cord-306325-9alfvda1	33	17	and	and	CC
cord-306325-9alfvda1	33	18	human	human	JJ
cord-306325-9alfvda1	33	19	coronaviruses	coronaviruse	NNS
cord-306325-9alfvda1	33	20	4	4	CD
cord-306325-9alfvda1	33	21	works	work	NNS
cord-306325-9alfvda1	33	22	against	against	IN
cord-306325-9alfvda1	33	23	the	the	DT
cord-306325-9alfvda1	33	24	assumption	assumption	NN
cord-306325-9alfvda1	33	25	that	that	IN
cord-306325-9alfvda1	33	26	the	the	DT
cord-306325-9alfvda1	33	27	same	same	JJ
cord-306325-9alfvda1	33	28	protein	protein	NN
cord-306325-9alfvda1	33	29	does	do	VBZ
cord-306325-9alfvda1	33	30	inhibit	inhibit	VB
cord-306325-9alfvda1	33	31	clearance	clearance	NN
cord-306325-9alfvda1	33	32	of	of	IN
cord-306325-9alfvda1	33	33	HCV	HCV	NNP
cord-306325-9alfvda1	33	34	,	,	,
cord-306325-9alfvda1	33	35	i.e.	i.e.	FW
cord-306325-9alfvda1	33	36	negatively	negatively	RB
cord-306325-9alfvda1	33	37	interfering	interfere	VBG
cord-306325-9alfvda1	33	38	with	with	IN
cord-306325-9alfvda1	33	39	HCV	HCV	NNP
cord-306325-9alfvda1	33	40	infection	infection	NN
cord-306325-9alfvda1	33	41	,	,	,
cord-306325-9alfvda1	33	42	while	while	IN
cord-306325-9alfvda1	33	43	being	be	VBG
cord-306325-9alfvda1	33	44	endowed	endow	VBN
cord-306325-9alfvda1	33	45	with	with	IN
cord-306325-9alfvda1	33	46	a	a	DT
cord-306325-9alfvda1	33	47	strong	strong	JJ
cord-306325-9alfvda1	33	48	anti	anti	JJ
cord-306325-9alfvda1	33	49	-	-	JJ
cord-306325-9alfvda1	33	50	HCV	hcv	JJ
cord-306325-9alfvda1	33	51	activity	activity	NN
cord-306325-9alfvda1	33	52	.	.	.
cord-306325-9alfvda1	34	1	This	this	DT
cord-306325-9alfvda1	34	2	suggests	suggest	VBZ
cord-306325-9alfvda1	34	3	the	the	DT
cord-306325-9alfvda1	34	4	existence	existence	NN
cord-306325-9alfvda1	34	5	of	of	IN
cord-306325-9alfvda1	34	6	a	a	DT
cord-306325-9alfvda1	34	7	complex	complex	JJ
cord-306325-9alfvda1	34	8	relationship	relationship	NN
cord-306325-9alfvda1	34	9	between	between	IN
cord-306325-9alfvda1	34	10	IFNL4	IFNL4	NNP
cord-306325-9alfvda1	34	11	and	and	CC
cord-306325-9alfvda1	34	12	HCV	HCV	NNP
cord-306325-9alfvda1	34	13	in	in	IN
cord-306325-9alfvda1	34	14	humans	human	NNS
cord-306325-9alfvda1	34	15	,	,	,
cord-306325-9alfvda1	34	16	similar	similar	JJ
cord-306325-9alfvda1	34	17	to	to	IN
cord-306325-9alfvda1	34	18	that	that	DT
cord-306325-9alfvda1	34	19	recently	recently	RB
cord-306325-9alfvda1	34	20	described	describe	VBN
cord-306325-9alfvda1	34	21	for	for	IN
cord-306325-9alfvda1	34	22	IFN-1	IFN-1	NNP
cord-306325-9alfvda1	34	23	and	and	CC
cord-306325-9alfvda1	34	24	lymphocytic	lymphocytic	JJ
cord-306325-9alfvda1	34	25	choriomeningitis	choriomeningitis	NNP
cord-306325-9alfvda1	34	26	virus	virus	NN
cord-306325-9alfvda1	34	27	in	in	IN
cord-306325-9alfvda1	34	28	mice	mouse	NNS
cord-306325-9alfvda1	34	29	,	,	,
cord-306325-9alfvda1	34	30	5	5	CD
cord-306325-9alfvda1	34	31	where	where	WRB
cord-306325-9alfvda1	34	32	chronic	chronic	JJ
cord-306325-9alfvda1	34	33	IFN	IFN	NNP
cord-306325-9alfvda1	34	34	-	-	HYPH
cord-306325-9alfvda1	34	35	I	I	NNP
cord-306325-9alfvda1	34	36	signalling	signal	VBG
cord-306325-9alfvda1	34	37	due	due	IN
cord-306325-9alfvda1	34	38	to	to	IN
cord-306325-9alfvda1	34	39	persistent	persistent	JJ
cord-306325-9alfvda1	34	40	infection	infection	NN
cord-306325-9alfvda1	34	41	drives	drive	VBZ
cord-306325-9alfvda1	34	42	immunosuppression	immunosuppression	NN
cord-306325-9alfvda1	34	43	and	and	CC
cord-306325-9alfvda1	34	44	disease	disease	NN
cord-306325-9alfvda1	34	45	progression	progression	NN
cord-306325-9alfvda1	34	46	.	.	.
cord-306325-9alfvda1	35	1	Although	although	IN
cord-306325-9alfvda1	35	2	validation	validation	NN
cord-306325-9alfvda1	35	3	studies	study	NNS
cord-306325-9alfvda1	35	4	in	in	IN
cord-306325-9alfvda1	35	5	large	large	JJ
cord-306325-9alfvda1	35	6	cohorts	cohort	NNS
cord-306325-9alfvda1	35	7	of	of	IN
cord-306325-9alfvda1	35	8	patients	patient	NNS
cord-306325-9alfvda1	35	9	,	,	,
cord-306325-9alfvda1	35	10	like	like	IN
cord-306325-9alfvda1	35	11	the	the	DT
cord-306325-9alfvda1	35	12	one	one	NN
cord-306325-9alfvda1	35	13	investigated	investigate	VBN
cord-306325-9alfvda1	35	14	by	by	IN
cord-306325-9alfvda1	35	15	St€	St€	NNP
cord-306325-9alfvda1	35	16	attermayer	attermayer	NNP
cord-306325-9alfvda1	35	17	et	et	NNP
cord-306325-9alfvda1	35	18	al	al	NNP
cord-306325-9alfvda1	36	1	.	.	.
cord-306325-9alfvda1	37	1	,	,	,
cord-306325-9alfvda1	37	2	1	1	CD
cord-306325-9alfvda1	37	3	may	may	MD
cord-306325-9alfvda1	37	4	help	help	VB
cord-306325-9alfvda1	37	5	understand	understand	VB
cord-306325-9alfvda1	37	6	the	the	DT
cord-306325-9alfvda1	37	7	clinical	clinical	JJ
cord-306325-9alfvda1	37	8	utility	utility	NN
cord-306325-9alfvda1	37	9	of	of	IN
cord-306325-9alfvda1	37	10	IFNL4	ifnl4	NN
cord-306325-9alfvda1	37	11	,	,	,
cord-306325-9alfvda1	37	12	these	these	DT
cord-306325-9alfvda1	37	13	studies	study	NNS
cord-306325-9alfvda1	37	14	have	have	VBP
cord-306325-9alfvda1	37	15	so	so	RB
cord-306325-9alfvda1	37	16	far	far	RB
cord-306325-9alfvda1	37	17	failed	fail	VBN
cord-306325-9alfvda1	37	18	to	to	TO
cord-306325-9alfvda1	37	19	demonstrate	demonstrate	VB
cord-306325-9alfvda1	37	20	any	any	DT
cord-306325-9alfvda1	37	21	causal	causal	JJ
cord-306325-9alfvda1	37	22	rela	rela	JJ
cord-306325-9alfvda1	37	23	-	-	HYPH
cord-306325-9alfvda1	37	24	tionship	tionship	NN
cord-306325-9alfvda1	37	25	between	between	IN
cord-306325-9alfvda1	37	26	IFNL4	ifnl4	NN
cord-306325-9alfvda1	37	27	protein	protein	NN
cord-306325-9alfvda1	37	28	and	and	CC
cord-306325-9alfvda1	37	29	nonresponse	nonresponse	NN
cord-306325-9alfvda1	37	30	to	to	IN
cord-306325-9alfvda1	37	31	interferon	interferon	NN
cord-306325-9alfvda1	37	32	therapy	therapy	NN
cord-306325-9alfvda1	37	33	in	in	IN
cord-306325-9alfvda1	37	34	chronic	chronic	JJ
cord-306325-9alfvda1	37	35	HCV	HCV	NNP
cord-306325-9alfvda1	37	36	patients	patient	NNS
cord-306325-9alfvda1	37	37	.	.	.
cord-306325-9alfvda1	38	1	Among	among	IN
cord-306325-9alfvda1	38	2	other	other	JJ
cord-306325-9alfvda1	38	3	approaches	approach	NNS
cord-306325-9alfvda1	38	4	,	,	,
cord-306325-9alfvda1	38	5	the	the	DT
cord-306325-9alfvda1	38	6	assessment	assessment	NN
cord-306325-9alfvda1	38	7	of	of	IN
cord-306325-9alfvda1	38	8	the	the	DT
cord-306325-9alfvda1	38	9	missense	missense	NN
cord-306325-9alfvda1	38	10	variants	variant	NNS
cord-306325-9alfvda1	38	11	previously	previously	RB
cord-306325-9alfvda1	38	12	described	describe	VBN
cord-306325-9alfvda1	38	13	in	in	IN
cord-306325-9alfvda1	38	14	the	the	DT
cord-306325-9alfvda1	38	15	IFNL4	ifnl4	NN
cord-306325-9alfvda1	38	16	coding	code	VBG
cord-306325-9alfvda1	38	17	region	region	NN
cord-306325-9alfvda1	38	18	,	,	,
cord-306325-9alfvda1	38	19	2	2	CD
cord-306325-9alfvda1	38	20	may	may	MD
cord-306325-9alfvda1	38	21	help	help	VB
cord-306325-9alfvda1	38	22	unravel	unravel	VB
cord-306325-9alfvda1	38	23	this	this	DT
cord-306325-9alfvda1	38	24	issue	issue	NN
cord-306325-9alfvda1	38	25	.	.	.
cord-306325-9alfvda1	39	1	Review	review	NN
cord-306325-9alfvda1	39	2	article	article	NN
cord-306325-9alfvda1	39	3	:	:	:
cord-306325-9alfvda1	39	4	vitamin	vitamin	NN
cord-306325-9alfvda1	39	5	D	d	NN
cord-306325-9alfvda1	39	6	and	and	CC
cord-306325-9alfvda1	39	7	inflammatory	inflammatory	JJ
cord-306325-9alfvda1	39	8	bowel	bowel	NN
cord-306325-9alfvda1	39	9	diseases	disease	NNS
cord-306325-9alfvda1	40	1	Psychological	psychological	JJ
cord-306325-9alfvda1	40	2	stress	stress	NN
cord-306325-9alfvda1	40	3	in	in	IN
cord-306325-9alfvda1	40	4	IBD	IBD	NNP
cord-306325-9alfvda1	40	5	:	:	:
cord-306325-9alfvda1	41	1	new	new	JJ
cord-306325-9alfvda1	41	2	insights	insight	NNS
cord-306325-9alfvda1	41	3	into	into	IN
cord-306325-9alfvda1	41	4	pathogenic	pathogenic	JJ
cord-306325-9alfvda1	41	5	and	and	CC
cord-306325-9alfvda1	41	6	therapeutic	therapeutic	JJ
cord-306325-9alfvda1	41	7	implications	implication	NNS
cord-306325-9alfvda1	42	1	Environmental	environmental	JJ
cord-306325-9alfvda1	42	2	triggers	trigger	NNS
cord-306325-9alfvda1	42	3	for	for	IN
cord-306325-9alfvda1	42	4	inflammatory	inflammatory	JJ
cord-306325-9alfvda1	42	5	bowel	bowel	NN
cord-306325-9alfvda1	42	6	disease	disease	NN
cord-306325-9alfvda1	42	7	Sleep	Sleep	NNP
cord-306325-9alfvda1	42	8	disturbances	disturbance	NNS
cord-306325-9alfvda1	42	9	and	and	CC
cord-306325-9alfvda1	42	10	inflammatory	inflammatory	JJ
cord-306325-9alfvda1	42	11	bowel	bowel	NN
cord-306325-9alfvda1	42	12	disease	disease	NN
cord-306325-9alfvda1	42	13	:	:	:
cord-306325-9alfvda1	42	14	a	a	DT
cord-306325-9alfvda1	42	15	potential	potential	JJ
cord-306325-9alfvda1	42	16	trigger	trigger	NN
cord-306325-9alfvda1	42	17	for	for	IN
cord-306325-9alfvda1	42	18	disease	disease	NN
cord-306325-9alfvda1	42	19	flare	flare	NN
cord-306325-9alfvda1	42	20	?	?	.
cord-306325-9alfvda1	43	1	Sleep	sleep	VB
cord-306325-9alfvda1	43	2	disturbance	disturbance	NN
cord-306325-9alfvda1	43	3	and	and	CC
cord-306325-9alfvda1	43	4	risk	risk	NN
cord-306325-9alfvda1	43	5	of	of	IN
cord-306325-9alfvda1	43	6	active	active	JJ
cord-306325-9alfvda1	43	7	disease	disease	NN
cord-306325-9alfvda1	43	8	in	in	IN
cord-306325-9alfvda1	43	9	patients	patient	NNS
cord-306325-9alfvda1	43	10	with	with	IN
cord-306325-9alfvda1	43	11	Crohn	Crohn	NNP
cord-306325-9alfvda1	43	12	's	's	POS
cord-306325-9alfvda1	43	13	disease	disease	NN
cord-306325-9alfvda1	43	14	and	and	CC
cord-306325-9alfvda1	43	15	ulcerative	ulcerative	JJ
cord-306325-9alfvda1	43	16	colitis	colitis	NN
cord-306325-9alfvda1	43	17	Assessment	Assessment	NNP
cord-306325-9alfvda1	43	18	of	of	IN
cord-306325-9alfvda1	43	19	the	the	DT
cord-306325-9alfvda1	43	20	relationship	relationship	NN
cord-306325-9alfvda1	43	21	between	between	IN
cord-306325-9alfvda1	43	22	quality	quality	NN
cord-306325-9alfvda1	43	23	of	of	IN
cord-306325-9alfvda1	43	24	sleep	sleep	NN
cord-306325-9alfvda1	43	25	and	and	CC
cord-306325-9alfvda1	43	26	disease	disease	NN
cord-306325-9alfvda1	43	27	activity	activity	NN
cord-306325-9alfvda1	43	28	in	in	IN
cord-306325-9alfvda1	43	29	inflammatory	inflammatory	JJ
cord-306325-9alfvda1	43	30	bowel	bowel	NN
cord-306325-9alfvda1	43	31	disease	disease	NN
cord-306325-9alfvda1	43	32	patients	patient	NNS
cord-306325-9alfvda1	43	33	Vitamin	vitamin	NN
cord-306325-9alfvda1	43	34	D	D	NNP
cord-306325-9alfvda1	43	35	deficiency	deficiency	NN
cord-306325-9alfvda1	43	36	and	and	CC
cord-306325-9alfvda1	43	37	depression	depression	NN
cord-306325-9alfvda1	43	38	in	in	IN
cord-306325-9alfvda1	43	39	adults	adult	NNS
cord-306325-9alfvda1	43	40	:	:	:
cord-306325-9alfvda1	43	41	systematic	systematic	JJ
cord-306325-9alfvda1	43	42	review	review	NN
cord-306325-9alfvda1	43	43	and	and	CC
cord-306325-9alfvda1	43	44	metaanalysis	metaanalysis	NN
cord-306325-9alfvda1	44	1	The	the	DT
cord-306325-9alfvda1	44	2	link	link	NN
cord-306325-9alfvda1	44	3	between	between	IN
cord-306325-9alfvda1	44	4	vitamin	vitamin	NN
cord-306325-9alfvda1	44	5	D	d	NN
cord-306325-9alfvda1	44	6	metabolism	metabolism	NN
cord-306325-9alfvda1	44	7	and	and	CC
cord-306325-9alfvda1	44	8	sleep	sleep	NN
cord-306325-9alfvda1	44	9	medicine	medicine	NN
cord-306325-9alfvda1	44	10	Polymorphisms	polymorphism	NNS
cord-306325-9alfvda1	44	11	of	of	IN
cord-306325-9alfvda1	44	12	interferon	interferon	NN
cord-306325-9alfvda1	44	13	-	-	HYPH
cord-306325-9alfvda1	44	14	k4	k4	NN
cord-306325-9alfvda1	44	15	and	and	CC
cord-306325-9alfvda1	45	1	IL28B	il28b	NN
cord-306325-9alfvda1	45	2	-effects	-effects	.
cord-306325-9alfvda1	46	1	on	on	IN
cord-306325-9alfvda1	46	2	treatment	treatment	NN
cord-306325-9alfvda1	46	3	response	response	NN
cord-306325-9alfvda1	46	4	to	to	IN
cord-306325-9alfvda1	46	5	interferon	interferon	NN
cord-306325-9alfvda1	46	6	/	/	,
cord-306325-9alfvda1	46	7	ribavirin	ribavirin	RB
cord-306325-9alfvda1	46	8	in	in	IN
cord-306325-9alfvda1	46	9	patients	patient	NNS
cord-306325-9alfvda1	46	10	with	with	IN
cord-306325-9alfvda1	46	11	chronic	chronic	JJ
cord-306325-9alfvda1	46	12	hepatitis	hepatitis	NN
cord-306325-9alfvda1	46	13	C	C	NNP
cord-306325-9alfvda1	46	14	A	A	NNP
cord-306325-9alfvda1	46	15	variant	variant	NN
cord-306325-9alfvda1	46	16	upstream	upstream	NN
cord-306325-9alfvda1	46	17	of	of	IN
cord-306325-9alfvda1	46	18	IFNL3	ifnl3	XX
cord-306325-9alfvda1	47	1	(	(	-LRB-
cord-306325-9alfvda1	47	2	IL28B	il28b	NN
cord-306325-9alfvda1	47	3	)	)	-RRB-
cord-306325-9alfvda1	47	4	creating	create	VBG
cord-306325-9alfvda1	47	5	a	a	DT
cord-306325-9alfvda1	47	6	new	new	JJ
cord-306325-9alfvda1	47	7	interferon	interferon	NN
cord-306325-9alfvda1	47	8	gene	gene	NN
cord-306325-9alfvda1	47	9	IFNL4	IFNL4	NNP
cord-306325-9alfvda1	47	10	is	be	VBZ
cord-306325-9alfvda1	47	11	associated	associate	VBN
cord-306325-9alfvda1	47	12	with	with	IN
cord-306325-9alfvda1	47	13	impaired	impaired	JJ
cord-306325-9alfvda1	47	14	clearance	clearance	NN
cord-306325-9alfvda1	47	15	of	of	IN
cord-306325-9alfvda1	47	16	hepatitis	hepatitis	NN
cord-306325-9alfvda1	47	17	C	C	NNP
cord-306325-9alfvda1	47	18	virus	virus	NN
cord-306325-9alfvda1	47	19	IL28B	il28b	IN
cord-306325-9alfvda1	47	20	expression	expression	NN
cord-306325-9alfvda1	47	21	depends	depend	VBZ
cord-306325-9alfvda1	47	22	on	on	IN
cord-306325-9alfvda1	47	23	a	a	DT
cord-306325-9alfvda1	47	24	novel	novel	JJ
cord-306325-9alfvda1	47	25	TT/-G	TT/-G	NNP
cord-306325-9alfvda1	47	26	polymorphism	polymorphism	NN
cord-306325-9alfvda1	47	27	which	which	WDT
cord-306325-9alfvda1	47	28	improves	improve	VBZ
cord-306325-9alfvda1	47	29	HCV	HCV	NNP
cord-306325-9alfvda1	47	30	clearance	clearance	NN
cord-306325-9alfvda1	47	31	prediction	prediction	NN
cord-306325-9alfvda1	47	32	Interferon	Interferon	NNP
cord-306325-9alfvda1	47	33	lambda	lambda	NN
cord-306325-9alfvda1	47	34	4	4	CD
cord-306325-9alfvda1	47	35	signals	signal	NNS
cord-306325-9alfvda1	47	36	via	via	IN
cord-306325-9alfvda1	47	37	the	the	DT
cord-306325-9alfvda1	47	38	IFNk	IFNk	NNS
cord-306325-9alfvda1	47	39	receptor	receptor	NN
cord-306325-9alfvda1	47	40	to	to	TO
cord-306325-9alfvda1	47	41	regulate	regulate	VB
cord-306325-9alfvda1	47	42	antiviral	antiviral	JJ
cord-306325-9alfvda1	47	43	activity	activity	NN
cord-306325-9alfvda1	47	44	against	against	IN
cord-306325-9alfvda1	47	45	HCV	HCV	NNP
cord-306325-9alfvda1	47	46	and	and	CC
cord-306325-9alfvda1	47	47	coronaviruses	coronaviruse	NNS
cord-306325-9alfvda1	47	48	Blockade	Blockade	NNP
cord-306325-9alfvda1	47	49	of	of	IN
cord-306325-9alfvda1	47	50	chronic	chronic	JJ
cord-306325-9alfvda1	47	51	type	type	NN
cord-306325-9alfvda1	48	1	I	-PRON-	PRP
cord-306325-9alfvda1	48	2	interferon	interferon	RB
cord-306325-9alfvda1	48	3	signaling	signal	VBG
cord-306325-9alfvda1	48	4	to	to	TO
cord-306325-9alfvda1	48	5	control	control	VB
cord-306325-9alfvda1	48	6	persistent	persistent	JJ
cord-306325-9alfvda1	48	7	LCMV	LCMV	NNP
cord-306325-9alfvda1	48	8	infection	infection	NN
cord-306325-9alfvda1	48	9	ACKNOWLEDGEMENT	ACKNOWLEDGEMENT	NNP
cord-306325-9alfvda1	48	10	Declaration	Declaration	NNP
cord-306325-9alfvda1	48	11	of	of	IN
cord-306325-9alfvda1	48	12	personal	personal	JJ
cord-306325-9alfvda1	48	13	and	and	CC
cord-306325-9alfvda1	48	14	funding	funding	NN
cord-306325-9alfvda1	48	15	interests	interest	NNS
cord-306325-9alfvda1	48	16	:	:	:
cord-306325-9alfvda1	49	1	None	none	NN
cord-306325-9alfvda1	49	2	.	.	.
cord-306325-9alfvda1	50	1	Declaration	declaration	NN
cord-306325-9alfvda1	50	2	of	of	IN
cord-306325-9alfvda1	50	3	personal	personal	JJ
cord-306325-9alfvda1	50	4	and	and	CC
cord-306325-9alfvda1	50	5	funding	funding	NN
cord-306325-9alfvda1	50	6	interests	interest	NNS
cord-306325-9alfvda1	50	7	:	:	:
cord-306325-9alfvda1	50	8	None	none	NN
cord-306325-9alfvda1	50	9	.	.	.
cord-306325-9alfvda1	51	1	SIRS	sirs	UH
cord-306325-9alfvda1	51	2	,	,	,
cord-306325-9alfvda1	51	3	We	-PRON-	PRP
cord-306325-9alfvda1	51	4	thank	thank	VBP
cord-306325-9alfvda1	51	5	Dr	Dr	NNP
cord-306325-9alfvda1	51	6	Galmozzi	Galmozzi	NNP
cord-306325-9alfvda1	51	7	and	and	CC
cord-306325-9alfvda1	51	8	Dr	Dr	NNP
cord-306325-9alfvda1	51	9	Lampertico	Lampertico	NNP
cord-306325-9alfvda1	51	10	for	for	IN
cord-306325-9alfvda1	51	11	their	-PRON-	PRP$
cord-306325-9alfvda1	51	12	comment	comment	NN
cord-306325-9alfvda1	51	13	on	on	IN
cord-306325-9alfvda1	51	14	our	-PRON-	PRP$
cord-306325-9alfvda1	51	15	recently	recently	RB
cord-306325-9alfvda1	51	16	published	publish	VBN
cord-306325-9alfvda1	51	17	paper	paper	NN
cord-306325-9alfvda1	51	18	on	on	IN
cord-306325-9alfvda1	51	19	the	the	DT
cord-306325-9alfvda1	51	20	effect	effect	NN
cord-306325-9alfvda1	51	21	of	of	IN
cord-306325-9alfvda1	51	22	the	the	DT
cord-306325-9alfvda1	51	23	dinucleotide	dinucleotide	NN
cord-306325-9alfvda1	51	24	frameshift	frameshift	NN
cord-306325-9alfvda1	51	25	variant	variant	NN
cord-306325-9alfvda1	51	26	in	in	IN
cord-306325-9alfvda1	51	27	ss469415590	ss469415590	NNP
cord-306325-9alfvda1	51	28	in	in	IN
cord-306325-9alfvda1	51	29	the	the	DT
cord-306325-9alfvda1	51	30	interferon	interferon	NN
cord-306325-9alfvda1	51	31	(	(	-LRB-
cord-306325-9alfvda1	51	32	IFN)-k4	IFN)-k4	NNP
cord-306325-9alfvda1	51	33	gene	gene	NN
cord-306325-9alfvda1	51	34	on	on	IN
cord-306325-9alfvda1	51	35	interferon	interferon	NN
cord-306325-9alfvda1	51	36	/	/	SYM
cord-306325-9alfvda1	51	37	ribavirin	ribavirin	NN
cord-306325-9alfvda1	51	38	treatment	treatment	NN
cord-306325-9alfvda1	51	39	and	and	CC
cord-306325-9alfvda1	51	40	its	-PRON-	PRP$
cord-306325-9alfvda1	51	41	relationship	relationship	NN
cord-306325-9alfvda1	51	42	with	with	IN
cord-306325-9alfvda1	51	43	the	the	DT
cord-306325-9alfvda1	51	44	two	two	CD
cord-306325-9alfvda1	51	45	commonly	commonly	RB
cord-306325-9alfvda1	51	46	used	use	VBN
cord-306325-9alfvda1	51	47	single	single	JJ
cord-306325-9alfvda1	51	48	nucleotide	nucleotide	JJ
cord-306325-9alfvda1	51	49	polymorphisms	polymorphism	NNS
cord-306325-9alfvda1	51	50	(	(	-LRB-
cord-306325-9alfvda1	51	51	SNP	SNP	NNP
cord-306325-9alfvda1	51	52	)	)	-RRB-
cord-306325-9alfvda1	51	53	in	in	IN
cord-306325-9alfvda1	51	54	IL28B	IL28B	NNP
cord-306325-9alfvda1	51	55	(	(	-LRB-
cord-306325-9alfvda1	51	56	rs12979860	rs12979860	NNP
cord-306325-9alfvda1	51	57	,	,	,
cord-306325-9alfvda1	51	58	rs8099917	rs8099917	LS
cord-306325-9alfvda1	51	59	)	)	-RRB-
cord-306325-9alfvda1	51	60	.	.	.
cord-306325-9alfvda1	52	1	1	1	CD
cord-306325-9alfvda1	52	2	,	,	,
cord-306325-9alfvda1	52	3	2	2	CD
cord-306325-9alfvda1	52	4	We	-PRON-	PRP
cord-306325-9alfvda1	52	5	agree	agree	VBP
cord-306325-9alfvda1	52	6	that	that	IN
cord-306325-9alfvda1	52	7	our	-PRON-	PRP$
cord-306325-9alfvda1	52	8	study	study	NN
cord-306325-9alfvda1	52	9	does	do	VBZ
cord-306325-9alfvda1	52	10	not	not	RB
cord-306325-9alfvda1	52	11	provide	provide	VB
cord-306325-9alfvda1	52	12	insights	insight	NNS
cord-306325-9alfvda1	52	13	on	on	IN
cord-306325-9alfvda1	52	14	the	the	DT
cord-306325-9alfvda1	52	15	causal	causal	JJ
cord-306325-9alfvda1	52	16	relationship	relationship	NN
cord-306325-9alfvda1	52	17	between	between	IN
cord-306325-9alfvda1	52	18	IFNL4	ifnl4	NN
cord-306325-9alfvda1	52	19	and	and	CC
cord-306325-9alfvda1	52	20	treatment	treatment	NN
cord-306325-9alfvda1	52	21	response	response	NN
cord-306325-9alfvda1	52	22	in	in	IN
cord-306325-9alfvda1	52	23	patients	patient	NNS
cord-306325-9alfvda1	52	24	with	with	IN
cord-306325-9alfvda1	52	25	chronic	chronic	JJ
cord-306325-9alfvda1	52	26	hepatitis	hepatitis	NN
cord-306325-9alfvda1	52	27	C	c	NN
cord-306325-9alfvda1	52	28	virus	virus	NN
cord-306325-9alfvda1	52	29	(	(	-LRB-
cord-306325-9alfvda1	52	30	HCV	HCV	NNP
cord-306325-9alfvda1	52	31	)	)	-RRB-
cord-306325-9alfvda1	52	32	infection	infection	NN
cord-306325-9alfvda1	52	33	.	.	.
cord-306325-9alfvda1	53	1	Nevertheless	nevertheless	RB
cord-306325-9alfvda1	53	2	,	,	,
cord-306325-9alfvda1	53	3	our	-PRON-	PRP$
cord-306325-9alfvda1	53	4	study	study	NN
cord-306325-9alfvda1	53	5	was	be	VBD
cord-306325-9alfvda1	53	6	designed	design	VBN
cord-306325-9alfvda1	53	7	to	to	TO
cord-306325-9alfvda1	53	8	investigate	investigate	VB
cord-306325-9alfvda1	53	9	the	the	DT
cord-306325-9alfvda1	53	10	clinical	clinical	JJ
cord-306325-9alfvda1	53	11	usefulness	usefulness	NN
cord-306325-9alfvda1	53	12	of	of	IN
cord-306325-9alfvda1	53	13	the	the	DT
cord-306325-9alfvda1	53	14	different	different	JJ
cord-306325-9alfvda1	53	15	SNPs	snp	NNS
cord-306325-9alfvda1	53	16	in	in	IN
cord-306325-9alfvda1	53	17	IL28B	IL28B	NNP
cord-306325-9alfvda1	54	1	and	and	CC
cord-306325-9alfvda1	54	2	IFNL4	ifnl4	RB
cord-306325-9alfvda1	54	3	in	in	IN
cord-306325-9alfvda1	54	4	a	a	DT
cord-306325-9alfvda1	54	5	large	large	JJ
cord-306325-9alfvda1	54	6	cohort	cohort	NN
cord-306325-9alfvda1	54	7	of	of	IN
cord-306325-9alfvda1	54	8	Caucasian	caucasian	JJ
cord-306325-9alfvda1	54	9	patients	patient	NNS
cord-306325-9alfvda1	54	10	infected	infect	VBN
cord-306325-9alfvda1	54	11	with	with	IN
cord-306325-9alfvda1	54	12	chronic	chronic	JJ
cord-306325-9alfvda1	54	13	HCV.Hamming	hcv.hamming	NN
cord-306325-9alfvda1	54	14	et	et	FW
cord-306325-9alfvda1	54	15	al	al	NNP
cord-306325-9alfvda1	54	16	.	.	.
cord-306325-9alfvda1	55	1	demonstrated	demonstrate	VBD
cord-306325-9alfvda1	55	2	that	that	IN
cord-306325-9alfvda1	55	3	IFNL4	ifnl4	PRP
cord-306325-9alfvda1	55	4	encodes	encode	VBZ
cord-306325-9alfvda1	55	5	an	an	DT
cord-306325-9alfvda1	55	6	active	active	JJ
cord-306325-9alfvda1	55	7	type	type	NN
cord-306325-9alfvda1	55	8	III	iii	CD
cord-306325-9alfvda1	55	9	interferon	interferon	NN
cord-306325-9alfvda1	55	10	with	with	IN
cord-306325-9alfvda1	55	11	potent	potent	JJ
cord-306325-9alfvda1	55	12	anti	anti	JJ
cord-306325-9alfvda1	55	13	-	-	JJ
cord-306325-9alfvda1	55	14	viral	viral	JJ
cord-306325-9alfvda1	55	15	activity	activity	NN
cord-306325-9alfvda1	55	16	against	against	IN
cord-306325-9alfvda1	55	17	both	both	CC
cord-306325-9alfvda1	55	18	HCV	HCV	NNP
cord-306325-9alfvda1	55	19	and	and	CC
cord-306325-9alfvda1	55	20	coronaviruses	coronaviruse	NNS
cord-306325-9alfvda1	55	21	.	.	.
cord-306325-9alfvda1	56	1	3	3	CD
cord-306325-9alfvda1	56	2	Galmozzi	Galmozzi	NNP
cord-306325-9alfvda1	56	3	and	and	CC
cord-306325-9alfvda1	56	4	Lampertico	Lampertico	NNP
cord-306325-9alfvda1	56	5	therefore	therefore	RB
cord-306325-9alfvda1	56	6	conclude	conclude	VBP
cord-306325-9alfvda1	56	7	that	that	IN
cord-306325-9alfvda1	56	8	this	this	DT
cord-306325-9alfvda1	56	9	strong	strong	JJ
cord-306325-9alfvda1	56	10	anti	anti	JJ
cord-306325-9alfvda1	56	11	-	-	JJ
cord-306325-9alfvda1	56	12	viral	viral	JJ
cord-306325-9alfvda1	56	13	activity	activity	NN
cord-306325-9alfvda1	56	14	works	work	VBZ
cord-306325-9alfvda1	56	15	against	against	IN
cord-306325-9alfvda1	56	16	the	the	DT
cord-306325-9alfvda1	56	17	assumption	assumption	NN
cord-306325-9alfvda1	56	18	of	of	IN
cord-306325-9alfvda1	56	19	an	an	DT
cord-306325-9alfvda1	56	20	inhibition	inhibition	NN
cord-306325-9alfvda1	56	21	of	of	IN
cord-306325-9alfvda1	56	22	the	the	DT
cord-306325-9alfvda1	56	23	IFNL4	IFNL4	NNP
cord-306325-9alfvda1	56	24	protein	protein	NN
cord-306325-9alfvda1	56	25	of	of	IN
cord-306325-9alfvda1	56	26	treatment	treatment	NN
cord-306325-9alfvda1	56	27	-	-	HYPH
cord-306325-9alfvda1	56	28	induced	induce	VBN
cord-306325-9alfvda1	56	29	HCV	HCV	NNP
cord-306325-9alfvda1	56	30	clearance	clearance	NN
cord-306325-9alfvda1	56	31	.	.	.
cord-306325-9alfvda1	57	1	We	-PRON-	PRP
cord-306325-9alfvda1	57	2	would	would	MD
cord-306325-9alfvda1	57	3	like	like	VB
cord-306325-9alfvda1	57	4	to	to	TO
cord-306325-9alfvda1	57	5	remind	remind	VB
cord-306325-9alfvda1	57	6	them	-PRON-	PRP
cord-306325-9alfvda1	57	7	that	that	IN
cord-306325-9alfvda1	57	8	up	up	JJ
cord-306325-9alfvda1	57	9	-	-	HYPH
cord-306325-9alfvda1	57	10	regulation	regulation	NN
cord-306325-9alfvda1	57	11	of	of	IN
cord-306325-9alfvda1	57	12	intrahepatic	intrahepatic	JJ
cord-306325-9alfvda1	57	13	interferon	interferon	NN
cord-306325-9alfvda1	57	14	-	-	HYPH
cord-306325-9alfvda1	57	15	stimulated	stimulate	VBN
cord-306325-9alfvda1	57	16	genes	gene	NNS
cord-306325-9alfvda1	57	17	(	(	-LRB-
cord-306325-9alfvda1	57	18	ISG	ISG	NNP
cord-306325-9alfvda1	57	19	)	)	-RRB-
cord-306325-9alfvda1	57	20	is	be	VBZ
cord-306325-9alfvda1	57	21	associated	associate	VBN
cord-306325-9alfvda1	57	22	with	with	IN
cord-306325-9alfvda1	57	23	treatment	treatment	NN
cord-306325-9alfvda1	57	24	failure	failure	NN
cord-306325-9alfvda1	57	25	in	in	IN
cord-306325-9alfvda1	57	26	patients	patient	NNS
cord-306325-9alfvda1	57	27	with	with	IN
cord-306325-9alfvda1	57	28	chronic	chronic	JJ
cord-306325-9alfvda1	57	29	HCV	HCV	NNP
cord-306325-9alfvda1	57	30	,	,	,
cord-306325-9alfvda1	57	31	and	and	CC
cord-306325-9alfvda1	57	32	levels	level	NNS
cord-306325-9alfvda1	57	33	of	of	IN
cord-306325-9alfvda1	57	34	ISG	ISG	NNP
cord-306325-9alfvda1	57	35	are	be	VBP
cord-306325-9alfvda1	57	36	differently	differently	RB
cord-306325-9alfvda1	57	37	distributed	distribute	VBN
cord-306325-9alfvda1	57	38	according	accord	VBG
cord-306325-9alfvda1	57	39	to	to	IN
cord-306325-9alfvda1	57	40	different	different	JJ
cord-306325-9alfvda1	57	41	IL28B	il28b	NN
cord-306325-9alfvda1	57	42	genotypes	genotype	NNS
cord-306325-9alfvda1	57	43	.	.	.
cord-306325-9alfvda1	58	1	4	4	LS
cord-306325-9alfvda1	59	1	Furthermore	furthermore	RB
cord-306325-9alfvda1	59	2	,	,	,
cord-306325-9alfvda1	59	3	Prokunina	Prokunina	NNP
cord-306325-9alfvda1	59	4	-	-	HYPH
cord-306325-9alfvda1	59	5	Olsson	Olsson	NNP
cord-306325-9alfvda1	59	6	and	and	CC
cord-306325-9alfvda1	59	7	her	-PRON-	PRP$
cord-306325-9alfvda1	59	8	collaborators	collaborator	NNS
cord-306325-9alfvda1	59	9	demonstrated	demonstrate	VBD
cord-306325-9alfvda1	59	10	that	that	IN
cord-306325-9alfvda1	59	11	IFNL4	IFNL4	NNP
cord-306325-9alfvda1	59	12	induces	induce	VBZ
cord-306325-9alfvda1	59	13	ISG	ISG	NNP
cord-306325-9alfvda1	59	14	expression	expression	NN
cord-306325-9alfvda1	59	15	in	in	IN
cord-306325-9alfvda1	59	16	HepG2	HepG2	NNP
cord-306325-9alfvda1	59	17	hepatoma	hepatoma	NN
cord-306325-9alfvda1	59	18	cells	cell	NNS
cord-306325-9alfvda1	59	19	.	.	.
cord-306325-9alfvda1	60	1	5	5	LS
cord-306325-9alfvda1	61	1	Thus	thus	RB
cord-306325-9alfvda1	61	2	,	,	,
cord-306325-9alfvda1	61	3	high	high	JJ
cord-306325-9alfvda1	61	4	baseline	baseline	NN
cord-306325-9alfvda1	61	5	ISG	ISG	NNP
cord-306325-9alfvda1	61	6	levels	level	NNS
cord-306325-9alfvda1	61	7	might	may	MD
cord-306325-9alfvda1	61	8	be	be	VB
cord-306325-9alfvda1	61	9	associated	associate	VBN
cord-306325-9alfvda1	61	10	with	with	IN
cord-306325-9alfvda1	61	11	poor	poor	JJ
cord-306325-9alfvda1	61	12	response	response	NN
cord-306325-9alfvda1	61	13	to	to	IN
cord-306325-9alfvda1	61	14	exogenous	exogenous	JJ
cord-306325-9alfvda1	61	15	IFN	IFN	NNP
cord-306325-9alfvda1	61	16	,	,	,
cord-306325-9alfvda1	61	17	by	by	IN
cord-306325-9alfvda1	61	18	exhausting	exhaust	VBG
cord-306325-9alfvda1	61	19	the	the	DT
cord-306325-9alfvda1	61	20	IFN	IFN	NNP
cord-306325-9alfvda1	61	21	response	response	NN
cord-306325-9alfvda1	61	22	pathways	pathway	NNS
cord-306325-9alfvda1	61	23	.	.	.
cord-306325-9alfvda1	62	1	6	6	CD
cord-306325-9alfvda1	62	2	 	 	_SP