id sid tid token lemma pos cord-023134-y665agnh 1 1 key key NN cord-023134-y665agnh 1 2 : : : cord-023134-y665agnh 2 1 cord-023134-y665agnh cord-023134-y665agnh NNP cord-023134-y665agnh 2 2 authors author NNS cord-023134-y665agnh 2 3 : : : cord-023134-y665agnh 3 1 nan nan NNP cord-023134-y665agnh 3 2 title title NN cord-023134-y665agnh 3 3 : : : cord-023134-y665agnh 3 4 Oral Oral NNP cord-023134-y665agnh 3 5 Research Research NNP cord-023134-y665agnh 3 6 Communications Communications NNPS cord-023134-y665agnh 3 7 of of IN cord-023134-y665agnh 3 8 the the DT cord-023134-y665agnh 3 9 22(nd 22(nd CD cord-023134-y665agnh 3 10 ) ) -RRB- cord-023134-y665agnh 4 1 ECVIM‐CA ecvim‐ca JJ cord-023134-y665agnh 4 2 Congress Congress NNP cord-023134-y665agnh 4 3 date date NN cord-023134-y665agnh 4 4 : : : cord-023134-y665agnh 4 5 2012 2012 CD cord-023134-y665agnh 4 6 - - SYM cord-023134-y665agnh 4 7 11 11 CD cord-023134-y665agnh 4 8 - - SYM cord-023134-y665agnh 4 9 20 20 CD cord-023134-y665agnh 4 10 journal journal NN cord-023134-y665agnh 4 11 : : : cord-023134-y665agnh 5 1 J J NNP cord-023134-y665agnh 5 2 Vet Vet NNP cord-023134-y665agnh 5 3 Intern Intern NNP cord-023134-y665agnh 5 4 Med Med NNP cord-023134-y665agnh 5 5 DOI doi NN cord-023134-y665agnh 5 6 : : : cord-023134-y665agnh 6 1 10.1111 10.1111 CD cord-023134-y665agnh 6 2 / / SYM cord-023134-y665agnh 6 3 jvim.12000 jvim.12000 NN cord-023134-y665agnh 6 4 sha sha NNP cord-023134-y665agnh 6 5 : : : cord-023134-y665agnh 7 1 d7c2c3bc1a45449c7cab34a2b73666f20fc02409 d7c2c3bc1a45449c7cab34a2b73666f20fc02409 LS cord-023134-y665agnh 8 1 doc_id doc_id LS cord-023134-y665agnh 8 2 : : : cord-023134-y665agnh 8 3 23134 23134 CD cord-023134-y665agnh 8 4 cord_uid cord_uid NNS cord-023134-y665agnh 8 5 : : : cord-023134-y665agnh 8 6 y665agnh y665agnh NNP cord-023134-y665agnh 8 7 nan nan NNP cord-023134-y665agnh 8 8 Sidestream Sidestream NNP cord-023134-y665agnh 8 9 dark dark JJ cord-023134-y665agnh 8 10 field field NN cord-023134-y665agnh 8 11 imaging imaging NN cord-023134-y665agnh 8 12 ( ( -LRB- cord-023134-y665agnh 8 13 SDF SDF NNP cord-023134-y665agnh 8 14 ) ) -RRB- cord-023134-y665agnh 8 15 is be VBZ cord-023134-y665agnh 8 16 a a DT cord-023134-y665agnh 8 17 technically technically RB cord-023134-y665agnh 8 18 relatively relatively RB cord-023134-y665agnh 8 19 simple simple JJ cord-023134-y665agnh 8 20 method method NN cord-023134-y665agnh 8 21 to to TO cord-023134-y665agnh 8 22 visualize visualize VB cord-023134-y665agnh 8 23 the the DT cord-023134-y665agnh 8 24 microcirculation microcirculation NN cord-023134-y665agnh 8 25 . . . cord-023134-y665agnh 9 1 However however RB cord-023134-y665agnh 9 2 , , , cord-023134-y665agnh 9 3 current current JJ cord-023134-y665agnh 9 4 gold gold NN cord-023134-y665agnh 9 5 - - HYPH cord-023134-y665agnh 9 6 standard standard NN cord-023134-y665agnh 9 7 , , , cord-023134-y665agnh 9 8 or or CC cord-023134-y665agnh 9 9 ' ' `` cord-023134-y665agnh 9 10 consensus consensus NN cord-023134-y665agnh 9 11 ' ' '' cord-023134-y665agnh 9 12 analysis analysis NN cord-023134-y665agnh 9 13 ( ( -LRB- cord-023134-y665agnh 9 14 CA CA NNP cord-023134-y665agnh 9 15 ) ) -RRB- cord-023134-y665agnh 9 16 of of IN cord-023134-y665agnh 9 17 SDF SDF NNP cord-023134-y665agnh 9 18 films film NNS cord-023134-y665agnh 9 19 takes take VBZ cord-023134-y665agnh 9 20 approximately approximately RB cord-023134-y665agnh 9 21 1 1 CD cord-023134-y665agnh 9 22 hour hour NN cord-023134-y665agnh 9 23 per per IN cord-023134-y665agnh 9 24 film film NN cord-023134-y665agnh 9 25 limiting limit VBG cord-023134-y665agnh 9 26 the the DT cord-023134-y665agnh 9 27 application application NN cord-023134-y665agnh 9 28 of of IN cord-023134-y665agnh 9 29 SDF SDF NNP cord-023134-y665agnh 9 30 in in IN cord-023134-y665agnh 9 31 a a DT cord-023134-y665agnh 9 32 clinical clinical JJ cord-023134-y665agnh 9 33 setting setting NN cord-023134-y665agnh 9 34 , , , cord-023134-y665agnh 9 35 and and CC cord-023134-y665agnh 9 36 leading lead VBG cord-023134-y665agnh 9 37 to to IN cord-023134-y665agnh 9 38 increased increase VBN cord-023134-y665agnh 9 39 expense expense NN cord-023134-y665agnh 9 40 due due IN cord-023134-y665agnh 9 41 to to IN cord-023134-y665agnh 9 42 analysis analysis NN cord-023134-y665agnh 9 43 of of IN cord-023134-y665agnh 9 44 low low JJ cord-023134-y665agnh 9 45 quality quality NN cord-023134-y665agnh 9 46 films film NNS cord-023134-y665agnh 9 47 . . . cord-023134-y665agnh 10 1 We -PRON- PRP cord-023134-y665agnh 10 2 developed develop VBD cord-023134-y665agnh 10 3 a a DT cord-023134-y665agnh 10 4 subjective subjective JJ cord-023134-y665agnh 10 5 point point NN cord-023134-y665agnh 10 6 of of IN cord-023134-y665agnh 10 7 care care NN cord-023134-y665agnh 10 8 scoring scoring NN cord-023134-y665agnh 10 9 system system NN cord-023134-y665agnh 10 10 ( ( -LRB- cord-023134-y665agnh 10 11 Bedside Bedside NNP cord-023134-y665agnh 10 12 evaluation evaluation NN cord-023134-y665agnh 10 13 of of IN cord-023134-y665agnh 10 14 the the DT cord-023134-y665agnh 10 15 microcirculation microcirculation NN cord-023134-y665agnh 10 16 , , , cord-023134-y665agnh 10 17 BEM BEM NNP cord-023134-y665agnh 10 18 ) ) -RRB- cord-023134-y665agnh 10 19 that that WDT cord-023134-y665agnh 10 20 could could MD cord-023134-y665agnh 10 21 provide provide VB cord-023134-y665agnh 10 22 real real JJ cord-023134-y665agnh 10 23 - - HYPH cord-023134-y665agnh 10 24 time time NN cord-023134-y665agnh 10 25 intervention intervention NN cord-023134-y665agnh 10 26 points point NNS cord-023134-y665agnh 10 27 and and CC cord-023134-y665agnh 10 28 optimize optimize VB cord-023134-y665agnh 10 29 care care NN cord-023134-y665agnh 10 30 for for IN cord-023134-y665agnh 10 31 the the DT cord-023134-y665agnh 10 32 critical critical JJ cord-023134-y665agnh 10 33 patient patient NN cord-023134-y665agnh 10 34 . . . cord-023134-y665agnh 11 1 The the DT cord-023134-y665agnh 11 2 objective objective NN cord-023134-y665agnh 11 3 of of IN cord-023134-y665agnh 11 4 this this DT cord-023134-y665agnh 11 5 study study NN cord-023134-y665agnh 11 6 is be VBZ cord-023134-y665agnh 11 7 to to TO cord-023134-y665agnh 11 8 evaluate evaluate VB cord-023134-y665agnh 11 9 whether whether IN cord-023134-y665agnh 11 10 the the DT cord-023134-y665agnh 11 11 BEM BEM NNP cord-023134-y665agnh 11 12 - - HYPH cord-023134-y665agnh 11 13 score score NN cord-023134-y665agnh 11 14 correctly correctly RB cord-023134-y665agnh 11 15 identifies identify VBZ cord-023134-y665agnh 11 16 films film NNS cord-023134-y665agnh 11 17 of of IN cord-023134-y665agnh 11 18 sufficient sufficient JJ cord-023134-y665agnh 11 19 and and CC cord-023134-y665agnh 11 20 insufficient insufficient JJ cord-023134-y665agnh 11 21 diagnostic diagnostic JJ cord-023134-y665agnh 11 22 quality quality NN cord-023134-y665agnh 11 23 as as IN cord-023134-y665agnh 11 24 defined define VBN cord-023134-y665agnh 11 25 by by IN cord-023134-y665agnh 11 26 CA.Twenty ca.twenty NN cord-023134-y665agnh 11 27 variable variable JJ cord-023134-y665agnh 11 28 - - HYPH cord-023134-y665agnh 11 29 length length NN cord-023134-y665agnh 11 30 microcirculation microcirculation NN cord-023134-y665agnh 11 31 films film NNS cord-023134-y665agnh 11 32 taken take VBN cord-023134-y665agnh 11 33 at at IN cord-023134-y665agnh 11 34 the the DT cord-023134-y665agnh 11 35 level level NN cord-023134-y665agnh 11 36 of of IN cord-023134-y665agnh 11 37 the the DT cord-023134-y665agnh 11 38 canine canine JJ cord-023134-y665agnh 11 39 tooth tooth NN cord-023134-y665agnh 11 40 were be VBD cord-023134-y665agnh 11 41 selected select VBN cord-023134-y665agnh 11 42 from from IN cord-023134-y665agnh 11 43 a a DT cord-023134-y665agnh 11 44 database database NN cord-023134-y665agnh 11 45 of of IN cord-023134-y665agnh 11 46 films film NNS cord-023134-y665agnh 11 47 with with IN cord-023134-y665agnh 11 48 available available JJ cord-023134-y665agnh 11 49 CA CA NNP cord-023134-y665agnh 11 50 . . . cord-023134-y665agnh 12 1 Before before IN cord-023134-y665agnh 12 2 the the DT cord-023134-y665agnh 12 3 study study NN cord-023134-y665agnh 12 4 , , , cord-023134-y665agnh 12 5 three three CD cord-023134-y665agnh 12 6 observers observer NNS cord-023134-y665agnh 12 7 were be VBD cord-023134-y665agnh 12 8 trained train VBN cord-023134-y665agnh 12 9 using use VBG cord-023134-y665agnh 12 10 an an DT cord-023134-y665agnh 12 11 instruction instruction NN cord-023134-y665agnh 12 12 video video NN cord-023134-y665agnh 12 13 to to TO cord-023134-y665agnh 12 14 evaluate evaluate VB cord-023134-y665agnh 12 15 five five CD cord-023134-y665agnh 12 16 quality quality NN cord-023134-y665agnh 12 17 parameters parameter NNS cord-023134-y665agnh 12 18 : : : cord-023134-y665agnh 12 19 stability stability NN cord-023134-y665agnh 12 20 , , , cord-023134-y665agnh 12 21 content content NN cord-023134-y665agnh 12 22 , , , cord-023134-y665agnh 12 23 illumination illumination NN cord-023134-y665agnh 12 24 , , , cord-023134-y665agnh 12 25 focus focus NN cord-023134-y665agnh 12 26 and and CC cord-023134-y665agnh 12 27 pressure pressure NN cord-023134-y665agnh 12 28 . . . cord-023134-y665agnh 13 1 The the DT cord-023134-y665agnh 13 2 BEM BEM NNP cord-023134-y665agnh 13 3 was be VBD cord-023134-y665agnh 13 4 performed perform VBN cord-023134-y665agnh 13 5 by by IN cord-023134-y665agnh 13 6 viewing view VBG cord-023134-y665agnh 13 7 and and CC cord-023134-y665agnh 13 8 scoring score VBG cord-023134-y665agnh 13 9 each each DT cord-023134-y665agnh 13 10 film film NN cord-023134-y665agnh 13 11 four four CD cord-023134-y665agnh 13 12 times time NNS cord-023134-y665agnh 13 13 in in IN cord-023134-y665agnh 13 14 immediate immediate JJ cord-023134-y665agnh 13 15 succession succession NN cord-023134-y665agnh 13 16 . . . cord-023134-y665agnh 14 1 All all DT cord-023134-y665agnh 14 2 five five CD cord-023134-y665agnh 14 3 quality quality NN cord-023134-y665agnh 14 4 parameters parameter NNS cord-023134-y665agnh 14 5 were be VBD cord-023134-y665agnh 14 6 scored score VBN cord-023134-y665agnh 14 7 ( ( -LRB- cord-023134-y665agnh 14 8 0 0 CD cord-023134-y665agnh 14 9 perfect perfect JJ cord-023134-y665agnh 14 10 , , , cord-023134-y665agnh 14 11 1 1 CD cord-023134-y665agnh 14 12 sufficient sufficient JJ cord-023134-y665agnh 14 13 and and CC cord-023134-y665agnh 14 14 2 2 CD cord-023134-y665agnh 14 15 insufficient insufficient JJ cord-023134-y665agnh 14 16 ) ) -RRB- cord-023134-y665agnh 14 17 according accord VBG cord-023134-y665agnh 14 18 to to IN cord-023134-y665agnh 14 19 CA CA NNP cord-023134-y665agnh 14 20 analysis analysis NN cord-023134-y665agnh 14 21 . . . cord-023134-y665agnh 15 1 Only only RB cord-023134-y665agnh 15 2 the the DT cord-023134-y665agnh 15 3 fourth fourth JJ cord-023134-y665agnh 15 4 viewing viewing NN cord-023134-y665agnh 15 5 was be VBD cord-023134-y665agnh 15 6 considered consider VBN cord-023134-y665agnh 15 7 for for IN cord-023134-y665agnh 15 8 analysis analysis NN cord-023134-y665agnh 15 9 . . . cord-023134-y665agnh 16 1 BEM BEM NNP cord-023134-y665agnh 16 2 quality quality NN cord-023134-y665agnh 16 3 analysis analysis NN cord-023134-y665agnh 16 4 was be VBD cord-023134-y665agnh 16 5 only only RB cord-023134-y665agnh 16 6 considered consider VBN cord-023134-y665agnh 16 7 sufficient sufficient JJ cord-023134-y665agnh 16 8 if if IN cord-023134-y665agnh 16 9 no no DT cord-023134-y665agnh 16 10 parameter parameter NN cord-023134-y665agnh 16 11 was be VBD cord-023134-y665agnh 16 12 scored score VBN cord-023134-y665agnh 16 13 insufficient insufficient JJ cord-023134-y665agnh 16 14 . . . cord-023134-y665agnh 17 1 Repeatability repeatability NN cord-023134-y665agnh 17 2 and and CC cord-023134-y665agnh 17 3 reproducibility reproducibility NN cord-023134-y665agnh 17 4 were be VBD cord-023134-y665agnh 17 5 assessed assess VBN cord-023134-y665agnh 17 6 by by IN cord-023134-y665agnh 17 7 assessing assess VBG cord-023134-y665agnh 17 8 all all DT cord-023134-y665agnh 17 9 films film NNS cord-023134-y665agnh 17 10 in in IN cord-023134-y665agnh 17 11 a a DT cord-023134-y665agnh 17 12 random random JJ cord-023134-y665agnh 17 13 order order NN cord-023134-y665agnh 17 14 three three CD cord-023134-y665agnh 17 15 times time NNS cord-023134-y665agnh 17 16 daily daily RB cord-023134-y665agnh 17 17 for for IN cord-023134-y665agnh 17 18 three three CD cord-023134-y665agnh 17 19 days day NNS cord-023134-y665agnh 17 20 . . . cord-023134-y665agnh 18 1 BEM BEM NNP cord-023134-y665agnh 18 2 pass pass VB cord-023134-y665agnh 18 3 - - HYPH cord-023134-y665agnh 18 4 fail fail VB cord-023134-y665agnh 18 5 assessment assessment NN cord-023134-y665agnh 18 6 matched match VBN cord-023134-y665agnh 18 7 CA CA NNP cord-023134-y665agnh 18 8 85.6 85.6 CD cord-023134-y665agnh 18 9 % % NN cord-023134-y665agnh 18 10 of of IN cord-023134-y665agnh 18 11 the the DT cord-023134-y665agnh 18 12 time time NN cord-023134-y665agnh 18 13 with with IN cord-023134-y665agnh 18 14 individual individual JJ cord-023134-y665agnh 18 15 observer observer NN cord-023134-y665agnh 18 16 agreement agreement NN cord-023134-y665agnh 18 17 of of IN cord-023134-y665agnh 18 18 84.4 84.4 CD cord-023134-y665agnh 18 19 - - HYPH cord-023134-y665agnh 18 20 87.8 87.8 CD cord-023134-y665agnh 18 21 % % NN cord-023134-y665agnh 18 22 . . . cord-023134-y665agnh 19 1 Agreement agreement NN cord-023134-y665agnh 19 2 of of IN cord-023134-y665agnh 19 3 BEM BEM NNP cord-023134-y665agnh 19 4 with with IN cord-023134-y665agnh 19 5 CA CA NNP cord-023134-y665agnh 19 6 did do VBD cord-023134-y665agnh 19 7 not not RB cord-023134-y665agnh 19 8 change change VB cord-023134-y665agnh 19 9 over over IN cord-023134-y665agnh 19 10 the the DT cord-023134-y665agnh 19 11 study study NN cord-023134-y665agnh 19 12 period period NN cord-023134-y665agnh 19 13 ( ( -LRB- cord-023134-y665agnh 19 14 84.4 84.4 CD cord-023134-y665agnh 19 15 % % NN cord-023134-y665agnh 19 16 , , , cord-023134-y665agnh 19 17 87.8 87.8 CD cord-023134-y665agnh 19 18 % % NN cord-023134-y665agnh 19 19 and and CC cord-023134-y665agnh 19 20 84.4 84.4 CD cord-023134-y665agnh 19 21 % % NN cord-023134-y665agnh 19 22 on on IN cord-023134-y665agnh 19 23 days day NNS cord-023134-y665agnh 19 24 1,2 1,2 CD cord-023134-y665agnh 19 25 and and CC cord-023134-y665agnh 19 26 3 3 CD cord-023134-y665agnh 19 27 respectively respectively RB cord-023134-y665agnh 19 28 ) ) -RRB- cord-023134-y665agnh 19 29 indicating indicate VBG cord-023134-y665agnh 19 30 accurate accurate JJ cord-023134-y665agnh 19 31 quality quality NN cord-023134-y665agnh 19 32 analysis analysis NN cord-023134-y665agnh 19 33 after after IN cord-023134-y665agnh 19 34 a a DT cord-023134-y665agnh 19 35 single single JJ cord-023134-y665agnh 19 36 BEM BEM NNP cord-023134-y665agnh 19 37 - - HYPH cord-023134-y665agnh 19 38 score score NN cord-023134-y665agnh 19 39 of of IN cord-023134-y665agnh 19 40 the the DT cord-023134-y665agnh 19 41 training training NN cord-023134-y665agnh 19 42 video video NN cord-023134-y665agnh 19 43 . . . cord-023134-y665agnh 20 1 The the DT cord-023134-y665agnh 20 2 mean mean JJ cord-023134-y665agnh 20 3 cumulative cumulative JJ cord-023134-y665agnh 20 4 BEM BEM NNP cord-023134-y665agnh 20 5 quality quality NN cord-023134-y665agnh 20 6 score score NN cord-023134-y665agnh 20 7 ( ( -LRB- cord-023134-y665agnh 20 8 2.51 2.51 CD cord-023134-y665agnh 20 9 , , , cord-023134-y665agnh 20 10 SD SD NNP cord-023134-y665agnh 20 11 1.87 1.87 CD cord-023134-y665agnh 20 12 ) ) -RRB- cord-023134-y665agnh 20 13 was be VBD cord-023134-y665agnh 20 14 very very RB cord-023134-y665agnh 20 15 similar similar JJ cord-023134-y665agnh 20 16 to to IN cord-023134-y665agnh 20 17 CA CA NNP cord-023134-y665agnh 20 18 ( ( -LRB- cord-023134-y665agnh 20 19 mean mean VB cord-023134-y665agnh 20 20 2.6 2.6 CD cord-023134-y665agnh 20 21 , , , cord-023134-y665agnh 20 22 SD SD NNP cord-023134-y665agnh 20 23 1.66 1.66 CD cord-023134-y665agnh 20 24 ) ) -RRB- cord-023134-y665agnh 20 25 . . . cord-023134-y665agnh 21 1 However however RB cord-023134-y665agnh 21 2 mean mean VB cord-023134-y665agnh 21 3 individual individual JJ cord-023134-y665agnh 21 4 BEMparameter bemparameter NN cord-023134-y665agnh 21 5 scores score NNS cord-023134-y665agnh 21 6 differed differ VBD cord-023134-y665agnh 21 7 from from IN cord-023134-y665agnh 21 8 CA CA NNP cord-023134-y665agnh 21 9 reflecting reflect VBG cord-023134-y665agnh 21 10 differences difference NNS cord-023134-y665agnh 21 11 in in IN cord-023134-y665agnh 21 12 observer observer NN cord-023134-y665agnh 21 13 interpretation interpretation NN cord-023134-y665agnh 21 14 . . . cord-023134-y665agnh 22 1 High high JJ cord-023134-y665agnh 22 2 levels level NNS cord-023134-y665agnh 22 3 of of IN cord-023134-y665agnh 22 4 inter inter JJ cord-023134-y665agnh 22 5 - - JJ cord-023134-y665agnh 22 6 observer observer JJ cord-023134-y665agnh 22 7 agreement agreement NN cord-023134-y665agnh 22 8 and and CC cord-023134-y665agnh 22 9 the the DT cord-023134-y665agnh 22 10 strong strong JJ cord-023134-y665agnh 22 11 correlation correlation NN cord-023134-y665agnh 22 12 with with IN cord-023134-y665agnh 22 13 CA CA NNP cord-023134-y665agnh 22 14 for for IN cord-023134-y665agnh 22 15 pass pass VB cord-023134-y665agnh 22 16 - - HYPH cord-023134-y665agnh 22 17 fail fail VB cord-023134-y665agnh 22 18 assessment assessment NN cord-023134-y665agnh 22 19 demonstrate demonstrate VBP cord-023134-y665agnh 22 20 that that IN cord-023134-y665agnh 22 21 BEM BEM NNP cord-023134-y665agnh 22 22 quality quality NN cord-023134-y665agnh 22 23 evaluation evaluation NN cord-023134-y665agnh 22 24 can can MD cord-023134-y665agnh 22 25 produce produce VB cord-023134-y665agnh 22 26 repeatable repeatable JJ cord-023134-y665agnh 22 27 and and CC cord-023134-y665agnh 22 28 reliable reliable JJ cord-023134-y665agnh 22 29 results result NNS cord-023134-y665agnh 22 30 . . . cord-023134-y665agnh 23 1 Variation variation NN cord-023134-y665agnh 23 2 in in IN cord-023134-y665agnh 23 3 individual individual JJ cord-023134-y665agnh 23 4 parameter parameter NN cord-023134-y665agnh 23 5 scores score NNS cord-023134-y665agnh 23 6 may may MD cord-023134-y665agnh 23 7 reflect reflect VB cord-023134-y665agnh 23 8 systematic systematic JJ cord-023134-y665agnh 23 9 erroneous erroneous JJ cord-023134-y665agnh 23 10 assignment assignment NN cord-023134-y665agnh 23 11 of of IN cord-023134-y665agnh 23 12 certain certain JJ cord-023134-y665agnh 23 13 parameters parameter NNS cord-023134-y665agnh 23 14 or or CC cord-023134-y665agnh 23 15 individual individual JJ cord-023134-y665agnh 23 16 bias bias NN cord-023134-y665agnh 23 17 towards towards IN cord-023134-y665agnh 23 18 assessment assessment NN cord-023134-y665agnh 23 19 of of IN cord-023134-y665agnh 23 20 certain certain JJ cord-023134-y665agnh 23 21 features feature NNS cord-023134-y665agnh 23 22 . . . cord-023134-y665agnh 24 1 Nevertheless nevertheless RB cord-023134-y665agnh 24 2 , , , cord-023134-y665agnh 24 3 this this DT cord-023134-y665agnh 24 4 did do VBD cord-023134-y665agnh 24 5 not not RB cord-023134-y665agnh 24 6 impact impact VB cord-023134-y665agnh 24 7 on on IN cord-023134-y665agnh 24 8 the the DT cord-023134-y665agnh 24 9 overall overall JJ cord-023134-y665agnh 24 10 evaluation evaluation NN cord-023134-y665agnh 24 11 of of IN cord-023134-y665agnh 24 12 film film NN cord-023134-y665agnh 24 13 quality quality NN cord-023134-y665agnh 24 14 . . . cord-023134-y665agnh 25 1 This this DT cord-023134-y665agnh 25 2 study study NN cord-023134-y665agnh 25 3 provides provide VBZ cord-023134-y665agnh 25 4 a a DT cord-023134-y665agnh 25 5 platform platform NN cord-023134-y665agnh 25 6 to to TO cord-023134-y665agnh 25 7 investigate investigate VB cord-023134-y665agnh 25 8 whether whether IN cord-023134-y665agnh 25 9 rapid rapid JJ cord-023134-y665agnh 25 10 semi semi JJ cord-023134-y665agnh 25 11 - - JJ cord-023134-y665agnh 25 12 quantitative quantitative JJ cord-023134-y665agnh 25 13 analysis analysis NN cord-023134-y665agnh 25 14 of of IN cord-023134-y665agnh 25 15 the the DT cord-023134-y665agnh 25 16 microcirculation microcirculation NN cord-023134-y665agnh 25 17 itself -PRON- PRP cord-023134-y665agnh 25 18 is be VBZ cord-023134-y665agnh 25 19 similarly similarly RB cord-023134-y665agnh 25 20 feasible feasible JJ cord-023134-y665agnh 25 21 . . . cord-023134-y665agnh 26 1 Sidestream sidestream JJ cord-023134-y665agnh 26 2 dark dark JJ cord-023134-y665agnh 26 3 field field NN cord-023134-y665agnh 26 4 imaging imaging NN cord-023134-y665agnh 26 5 ( ( -LRB- cord-023134-y665agnh 26 6 SDF SDF NNP cord-023134-y665agnh 26 7 ) ) -RRB- cord-023134-y665agnh 26 8 is be VBZ cord-023134-y665agnh 26 9 a a DT cord-023134-y665agnh 26 10 straightforward straightforward JJ cord-023134-y665agnh 26 11 technique technique NN cord-023134-y665agnh 26 12 to to TO cord-023134-y665agnh 26 13 evaluate evaluate VB cord-023134-y665agnh 26 14 microcirculation microcirculation NN cord-023134-y665agnh 26 15 . . . cord-023134-y665agnh 27 1 However however RB cord-023134-y665agnh 27 2 , , , cord-023134-y665agnh 27 3 current current JJ cord-023134-y665agnh 27 4 ' ' `` cord-023134-y665agnh 27 5 consensus consensus NN cord-023134-y665agnh 27 6 ' ' '' cord-023134-y665agnh 27 7 analysis analysis NN cord-023134-y665agnh 27 8 ( ( -LRB- cord-023134-y665agnh 27 9 CA CA NNP cord-023134-y665agnh 27 10 ) ) -RRB- cord-023134-y665agnh 27 11 of of IN cord-023134-y665agnh 27 12 SDF SDF NNP cord-023134-y665agnh 27 13 films film NNS cord-023134-y665agnh 27 14 is be VBZ cord-023134-y665agnh 27 15 time time NN cord-023134-y665agnh 27 16 - - HYPH cord-023134-y665agnh 27 17 consuming consume VBG cord-023134-y665agnh 27 18 , , , cord-023134-y665agnh 27 19 thereby thereby RB cord-023134-y665agnh 27 20 restricting restrict VBG cord-023134-y665agnh 27 21 the the DT cord-023134-y665agnh 27 22 clinical clinical JJ cord-023134-y665agnh 27 23 application application NN cord-023134-y665agnh 27 24 of of IN cord-023134-y665agnh 27 25 SDF SDF NNP cord-023134-y665agnh 27 26 . . . cord-023134-y665agnh 28 1 A a DT cord-023134-y665agnh 28 2 subjective subjective JJ cord-023134-y665agnh 28 3 bedside bedside NN cord-023134-y665agnh 28 4 scoring scoring NN cord-023134-y665agnh 28 5 system system NN cord-023134-y665agnh 28 6 ( ( -LRB- cord-023134-y665agnh 28 7 BEM BEM NNP cord-023134-y665agnh 28 8 ) ) -RRB- cord-023134-y665agnh 28 9 is be VBZ cord-023134-y665agnh 28 10 proposed propose VBN cord-023134-y665agnh 28 11 that that WDT cord-023134-y665agnh 28 12 could could MD cord-023134-y665agnh 28 13 rapidly rapidly RB cord-023134-y665agnh 28 14 provide provide VB cord-023134-y665agnh 28 15 a a DT cord-023134-y665agnh 28 16 semi semi JJ cord-023134-y665agnh 28 17 - - JJ cord-023134-y665agnh 28 18 quantitative quantitative JJ cord-023134-y665agnh 28 19 assessment assessment NN cord-023134-y665agnh 28 20 . . . cord-023134-y665agnh 29 1 We -PRON- PRP cord-023134-y665agnh 29 2 have have VBP cord-023134-y665agnh 29 3 previously previously RB cord-023134-y665agnh 29 4 shown show VBN cord-023134-y665agnh 29 5 that that IN cord-023134-y665agnh 29 6 observers observer NNS cord-023134-y665agnh 29 7 could could MD cord-023134-y665agnh 29 8 accurately accurately RB cord-023134-y665agnh 29 9 evaluate evaluate VB cord-023134-y665agnh 29 10 film film NN cord-023134-y665agnh 29 11 quality quality NN cord-023134-y665agnh 29 12 parameters parameter NNS cord-023134-y665agnh 29 13 . . . cord-023134-y665agnh 30 1 The the DT cord-023134-y665agnh 30 2 objective objective NN cord-023134-y665agnh 30 3 of of IN cord-023134-y665agnh 30 4 the the DT cord-023134-y665agnh 30 5 present present JJ cord-023134-y665agnh 30 6 study study NN cord-023134-y665agnh 30 7 is be VBZ cord-023134-y665agnh 30 8 to to TO cord-023134-y665agnh 30 9 assess assess VB cord-023134-y665agnh 30 10 the the DT cord-023134-y665agnh 30 11 correlation correlation NN cord-023134-y665agnh 30 12 of of IN cord-023134-y665agnh 30 13 BEM BEM NNP cord-023134-y665agnh 30 14 with with IN cord-023134-y665agnh 30 15 CA CA NNP cord-023134-y665agnh 30 16 for for IN cord-023134-y665agnh 30 17 quantitative quantitative JJ cord-023134-y665agnh 30 18 microcirculation microcirculation NN cord-023134-y665agnh 30 19 parameters parameter NNS cord-023134-y665agnh 30 20 . . . cord-023134-y665agnh 31 1 Three three CD cord-023134-y665agnh 31 2 observers observer NNS cord-023134-y665agnh 31 3 were be VBD cord-023134-y665agnh 31 4 trained train VBN cord-023134-y665agnh 31 5 using use VBG cord-023134-y665agnh 31 6 an an DT cord-023134-y665agnh 31 7 instruction instruction NN cord-023134-y665agnh 31 8 video video NN cord-023134-y665agnh 31 9 to to TO cord-023134-y665agnh 31 10 evaluate evaluate VB cord-023134-y665agnh 31 11 four four CD cord-023134-y665agnh 31 12 quantity quantity NN cord-023134-y665agnh 31 13 parameters parameter NNS cord-023134-y665agnh 31 14 : : : cord-023134-y665agnh 31 15 total total JJ cord-023134-y665agnh 31 16 vessel vessel NN cord-023134-y665agnh 31 17 density density NN cord-023134-y665agnh 31 18 ( ( -LRB- cord-023134-y665agnh 31 19 TVD TVD NNP cord-023134-y665agnh 31 20 ) ) -RRB- cord-023134-y665agnh 31 21 , , , cord-023134-y665agnh 31 22 capillary capillary JJ cord-023134-y665agnh 31 23 vessel vessel NN cord-023134-y665agnh 31 24 density density NN cord-023134-y665agnh 31 25 ( ( -LRB- cord-023134-y665agnh 31 26 CVD CVD NNP cord-023134-y665agnh 31 27 ) ) -RRB- cord-023134-y665agnh 31 28 , , , cord-023134-y665agnh 31 29 perfused perfuse VBN cord-023134-y665agnh 31 30 vessel vessel NN cord-023134-y665agnh 31 31 density density NN cord-023134-y665agnh 31 32 ( ( -LRB- cord-023134-y665agnh 31 33 PVD PVD NNP cord-023134-y665agnh 31 34 ) ) -RRB- cord-023134-y665agnh 31 35 and and CC cord-023134-y665agnh 31 36 microvascular microvascular JJ cord-023134-y665agnh 31 37 flow flow NN cord-023134-y665agnh 31 38 index index NN cord-023134-y665agnh 31 39 ( ( -LRB- cord-023134-y665agnh 31 40 MFI MFI NNP cord-023134-y665agnh 31 41 ) ) -RRB- cord-023134-y665agnh 31 42 . . . cord-023134-y665agnh 32 1 Fifteen fifteen CD cord-023134-y665agnh 32 2 variable variable JJ cord-023134-y665agnh 32 3 - - HYPH cord-023134-y665agnh 32 4 length length NN cord-023134-y665agnh 32 5 microcirculation microcirculation NN cord-023134-y665agnh 32 6 films film NNS cord-023134-y665agnh 32 7 of of IN cord-023134-y665agnh 32 8 sufficient sufficient JJ cord-023134-y665agnh 32 9 quality quality NN cord-023134-y665agnh 32 10 , , , cord-023134-y665agnh 32 11 taken take VBN cord-023134-y665agnh 32 12 at at IN cord-023134-y665agnh 32 13 the the DT cord-023134-y665agnh 32 14 level level NN cord-023134-y665agnh 32 15 of of IN cord-023134-y665agnh 32 16 the the DT cord-023134-y665agnh 32 17 canine canine JJ cord-023134-y665agnh 32 18 tooth tooth NN cord-023134-y665agnh 32 19 , , , cord-023134-y665agnh 32 20 were be VBD cord-023134-y665agnh 32 21 selected select VBN cord-023134-y665agnh 32 22 from from IN cord-023134-y665agnh 32 23 a a DT cord-023134-y665agnh 32 24 database database NN cord-023134-y665agnh 32 25 of of IN cord-023134-y665agnh 32 26 films film NNS cord-023134-y665agnh 32 27 with with IN cord-023134-y665agnh 32 28 available available JJ cord-023134-y665agnh 32 29 consensus consensus NN cord-023134-y665agnh 32 30 analysis analysis NN cord-023134-y665agnh 32 31 . . . cord-023134-y665agnh 33 1 Each each DT cord-023134-y665agnh 33 2 parameter parameter NN cord-023134-y665agnh 33 3 was be VBD cord-023134-y665agnh 33 4 scored score VBN cord-023134-y665agnh 33 5 ( ( -LRB- cord-023134-y665agnh 33 6 1 1 CD cord-023134-y665agnh 33 7 lowest lowest RBS cord-023134-y665agnh 33 8 -5 -5 RB cord-023134-y665agnh 33 9 highest high JJS cord-023134-y665agnh 33 10 ) ) -RRB- cord-023134-y665agnh 33 11 . . . cord-023134-y665agnh 34 1 The the DT cord-023134-y665agnh 34 2 BEM BEM NNP cord-023134-y665agnh 34 3 was be VBD cord-023134-y665agnh 34 4 performed perform VBN cord-023134-y665agnh 34 5 by by IN cord-023134-y665agnh 34 6 viewing view VBG cord-023134-y665agnh 34 7 and and CC cord-023134-y665agnh 34 8 scoring score VBG cord-023134-y665agnh 34 9 each each DT cord-023134-y665agnh 34 10 film film NN cord-023134-y665agnh 34 11 four four CD cord-023134-y665agnh 34 12 times time NNS cord-023134-y665agnh 34 13 in in IN cord-023134-y665agnh 34 14 immediate immediate JJ cord-023134-y665agnh 34 15 succession succession NN cord-023134-y665agnh 34 16 with with IN cord-023134-y665agnh 34 17 the the DT cord-023134-y665agnh 34 18 final final JJ cord-023134-y665agnh 34 19 score score NN cord-023134-y665agnh 34 20 being be VBG cord-023134-y665agnh 34 21 considered consider VBN cord-023134-y665agnh 34 22 for for IN cord-023134-y665agnh 34 23 analysis analysis NN cord-023134-y665agnh 34 24 . . . cord-023134-y665agnh 35 1 BEM BEM NNP cord-023134-y665agnh 35 2 was be VBD cord-023134-y665agnh 35 3 performed perform VBN cord-023134-y665agnh 35 4 on on IN cord-023134-y665agnh 35 5 each each DT cord-023134-y665agnh 35 6 film film NN cord-023134-y665agnh 35 7 in in IN cord-023134-y665agnh 35 8 random random JJ cord-023134-y665agnh 35 9 order order NN cord-023134-y665agnh 35 10 three three CD cord-023134-y665agnh 35 11 times time NNS cord-023134-y665agnh 35 12 daily daily RB cord-023134-y665agnh 35 13 for for IN cord-023134-y665agnh 35 14 three three CD cord-023134-y665agnh 35 15 days day NNS cord-023134-y665agnh 35 16 . . . cord-023134-y665agnh 36 1 CA CA NNP cord-023134-y665agnh 36 2 scores score NNS cord-023134-y665agnh 36 3 were be VBD cord-023134-y665agnh 36 4 divided divide VBN cord-023134-y665agnh 36 5 into into IN cord-023134-y665agnh 36 6 quintiles quintile NNS cord-023134-y665agnh 36 7 for for IN cord-023134-y665agnh 36 8 each each DT cord-023134-y665agnh 36 9 parameter parameter NN cord-023134-y665agnh 36 10 and and CC cord-023134-y665agnh 36 11 mean mean VB cord-023134-y665agnh 36 12 BEM BEM NNP cord-023134-y665agnh 36 13 score score NN cord-023134-y665agnh 36 14 were be VBD cord-023134-y665agnh 36 15 calculated calculate VBN cord-023134-y665agnh 36 16 for for IN cord-023134-y665agnh 36 17 each each DT cord-023134-y665agnh 36 18 . . . cord-023134-y665agnh 37 1 Conversely conversely RB cord-023134-y665agnh 37 2 , , , cord-023134-y665agnh 37 3 for for IN cord-023134-y665agnh 37 4 each each DT cord-023134-y665agnh 37 5 BEM BEM NNP cord-023134-y665agnh 37 6 score score NN cord-023134-y665agnh 37 7 , , , cord-023134-y665agnh 37 8 mean mean VB cord-023134-y665agnh 37 9 CA CA NNP cord-023134-y665agnh 37 10 scores score NNS cord-023134-y665agnh 37 11 were be VBD cord-023134-y665agnh 37 12 calculated calculate VBN cord-023134-y665agnh 37 13 , , , cord-023134-y665agnh 37 14 per per IN cord-023134-y665agnh 37 15 observer observer NN cord-023134-y665agnh 37 16 or or CC cord-023134-y665agnh 37 17 per per IN cord-023134-y665agnh 37 18 day day NN cord-023134-y665agnh 37 19 . . . cord-023134-y665agnh 38 1 The the DT cord-023134-y665agnh 38 2 mean mean JJ cord-023134-y665agnh 38 3 TVD TVD NNP cord-023134-y665agnh 38 4 and and CC cord-023134-y665agnh 38 5 PVD PVD NNP cord-023134-y665agnh 38 6 BEM BEM NNP cord-023134-y665agnh 38 7 scores score NNS cord-023134-y665agnh 38 8 for for IN cord-023134-y665agnh 38 9 the the DT cord-023134-y665agnh 38 10 20 20 CD cord-023134-y665agnh 38 11 % % NN cord-023134-y665agnh 38 12 quintile quintile NN cord-023134-y665agnh 38 13 were be VBD cord-023134-y665agnh 38 14 lower low JJR cord-023134-y665agnh 38 15 than than IN cord-023134-y665agnh 38 16 mean mean VB cord-023134-y665agnh 38 17 BEM BEM NNP cord-023134-y665agnh 38 18 scores score NNS cord-023134-y665agnh 38 19 for for IN cord-023134-y665agnh 38 20 other other JJ cord-023134-y665agnh 38 21 quintiles quintile NNS cord-023134-y665agnh 38 22 . . . cord-023134-y665agnh 39 1 Mean mean JJ cord-023134-y665agnh 39 2 BEM BEM NNP cord-023134-y665agnh 39 3 score score VB cord-023134-y665agnh 39 4 for for IN cord-023134-y665agnh 39 5 the the DT cord-023134-y665agnh 39 6 80 80 CD cord-023134-y665agnh 39 7 - - SYM cord-023134-y665agnh 39 8 100 100 CD cord-023134-y665agnh 39 9 % % NN cord-023134-y665agnh 39 10 quintile quintile NN cord-023134-y665agnh 39 11 was be VBD cord-023134-y665agnh 39 12 the the DT cord-023134-y665agnh 39 13 highest high JJS cord-023134-y665agnh 39 14 mean mean JJ cord-023134-y665agnh 39 15 BEM BEM NNP cord-023134-y665agnh 39 16 score score NN cord-023134-y665agnh 39 17 for for IN cord-023134-y665agnh 39 18 PVD PVD NNP cord-023134-y665agnh 39 19 only only RB cord-023134-y665agnh 39 20 . . . cord-023134-y665agnh 40 1 Mean mean JJ cord-023134-y665agnh 40 2 CVD CVD NNP cord-023134-y665agnh 40 3 , , , cord-023134-y665agnh 40 4 PVD PVD NNP cord-023134-y665agnh 40 5 and and CC cord-023134-y665agnh 40 6 MFI MFI NNP cord-023134-y665agnh 40 7 values value NNS cord-023134-y665agnh 40 8 for for IN cord-023134-y665agnh 40 9 BEM BEM NNP cord-023134-y665agnh 40 10 score score NN cord-023134-y665agnh 40 11 1 1 CD cord-023134-y665agnh 40 12 were be VBD cord-023134-y665agnh 40 13 lower low JJR cord-023134-y665agnh 40 14 than than IN cord-023134-y665agnh 40 15 mean mean JJ cord-023134-y665agnh 40 16 values value NNS cord-023134-y665agnh 40 17 for for IN cord-023134-y665agnh 40 18 other other JJ cord-023134-y665agnh 40 19 BEM BEM NNP cord-023134-y665agnh 40 20 scores score NNS cord-023134-y665agnh 40 21 . . . cord-023134-y665agnh 41 1 In in IN cord-023134-y665agnh 41 2 parallel parallel NN cord-023134-y665agnh 41 3 , , , cord-023134-y665agnh 41 4 although although IN cord-023134-y665agnh 41 5 TVD TVD NNP cord-023134-y665agnh 41 6 never never RB cord-023134-y665agnh 41 7 received receive VBD cord-023134-y665agnh 41 8 a a DT cord-023134-y665agnh 41 9 BEM BEM NNP cord-023134-y665agnh 41 10 score score NN cord-023134-y665agnh 41 11 of of IN cord-023134-y665agnh 41 12 1 1 CD cord-023134-y665agnh 41 13 , , , cord-023134-y665agnh 41 14 the the DT cord-023134-y665agnh 41 15 mean mean NN cord-023134-y665agnh 41 16 CA CA NNP cord-023134-y665agnh 41 17 value value NN cord-023134-y665agnh 41 18 for for IN cord-023134-y665agnh 41 19 films film NNS cord-023134-y665agnh 41 20 with with IN cord-023134-y665agnh 41 21 BEM BEM NNP cord-023134-y665agnh 41 22 score score NN cord-023134-y665agnh 41 23 2 2 CD cord-023134-y665agnh 41 24 were be VBD cord-023134-y665agnh 41 25 lower low JJR cord-023134-y665agnh 41 26 than than IN cord-023134-y665agnh 41 27 for for IN cord-023134-y665agnh 41 28 higher high JJR cord-023134-y665agnh 41 29 BEM BEM NNP cord-023134-y665agnh 41 30 scores score NNS cord-023134-y665agnh 41 31 . . . cord-023134-y665agnh 42 1 The the DT cord-023134-y665agnh 42 2 mean mean JJ cord-023134-y665agnh 42 3 TVD TVD NNP cord-023134-y665agnh 42 4 and and CC cord-023134-y665agnh 42 5 MFI MFI NNP cord-023134-y665agnh 42 6 values value NNS cord-023134-y665agnh 42 7 for for IN cord-023134-y665agnh 42 8 BEM BEM NNP cord-023134-y665agnh 42 9 score score NN cord-023134-y665agnh 42 10 of of IN cord-023134-y665agnh 42 11 5 5 CD cord-023134-y665agnh 42 12 were be VBD cord-023134-y665agnh 42 13 higher high JJR cord-023134-y665agnh 42 14 than than IN cord-023134-y665agnh 42 15 mean mean JJ cord-023134-y665agnh 42 16 values value NNS cord-023134-y665agnh 42 17 for for IN cord-023134-y665agnh 42 18 BEM BEM NNP cord-023134-y665agnh 42 19 scores score NNS cord-023134-y665agnh 42 20 [ [ -LRB- cord-023134-y665agnh 42 21 1 1 CD cord-023134-y665agnh 42 22 ] ] -RRB- cord-023134-y665agnh 42 23 [ [ -LRB- cord-023134-y665agnh 42 24 2 2 CD cord-023134-y665agnh 42 25 ] ] -RRB- cord-023134-y665agnh 42 26 [ [ -LRB- cord-023134-y665agnh 42 27 3 3 CD cord-023134-y665agnh 42 28 ] ] -RRB- cord-023134-y665agnh 42 29 [ [ -LRB- cord-023134-y665agnh 42 30 4 4 CD cord-023134-y665agnh 42 31 ] ] -RRB- cord-023134-y665agnh 42 32 . . . cord-023134-y665agnh 43 1 Similar similar JJ cord-023134-y665agnh 43 2 values value NNS cord-023134-y665agnh 43 3 were be VBD cord-023134-y665agnh 43 4 obtained obtain VBN cord-023134-y665agnh 43 5 on on IN cord-023134-y665agnh 43 6 each each DT cord-023134-y665agnh 43 7 individual individual JJ cord-023134-y665agnh 43 8 study study NN cord-023134-y665agnh 43 9 day day NN cord-023134-y665agnh 43 10 . . . cord-023134-y665agnh 44 1 This this DT cord-023134-y665agnh 44 2 study study NN cord-023134-y665agnh 44 3 demonstrates demonstrate VBZ cord-023134-y665agnh 44 4 that that IN cord-023134-y665agnh 44 5 rapid rapid JJ cord-023134-y665agnh 44 6 semi semi JJ cord-023134-y665agnh 44 7 - - JJ cord-023134-y665agnh 44 8 quantitative quantitative JJ cord-023134-y665agnh 44 9 assessment assessment NN cord-023134-y665agnh 44 10 of of IN cord-023134-y665agnh 44 11 the the DT cord-023134-y665agnh 44 12 microcirculation microcirculation NN cord-023134-y665agnh 44 13 using use VBG cord-023134-y665agnh 44 14 the the DT cord-023134-y665agnh 44 15 BEM BEM NNP cord-023134-y665agnh 44 16 - - HYPH cord-023134-y665agnh 44 17 score score NN cord-023134-y665agnh 44 18 can can MD cord-023134-y665agnh 44 19 produce produce VB cord-023134-y665agnh 44 20 repeatable repeatable JJ cord-023134-y665agnh 44 21 and and CC cord-023134-y665agnh 44 22 reliable reliable JJ cord-023134-y665agnh 44 23 results result NNS cord-023134-y665agnh 44 24 , , , cord-023134-y665agnh 44 25 although although IN cord-023134-y665agnh 44 26 significant significant JJ cord-023134-y665agnh 44 27 overlap overlap NN cord-023134-y665agnh 44 28 exists exist VBZ cord-023134-y665agnh 44 29 . . . cord-023134-y665agnh 45 1 Further further JJ cord-023134-y665agnh 45 2 studies study NNS cord-023134-y665agnh 45 3 are be VBP cord-023134-y665agnh 45 4 required require VBN cord-023134-y665agnh 45 5 to to TO cord-023134-y665agnh 45 6 evaluate evaluate VB cord-023134-y665agnh 45 7 the the DT cord-023134-y665agnh 45 8 value value NN cord-023134-y665agnh 45 9 of of IN cord-023134-y665agnh 45 10 this this DT cord-023134-y665agnh 45 11 technique technique NN cord-023134-y665agnh 45 12 in in IN cord-023134-y665agnh 45 13 a a DT cord-023134-y665agnh 45 14 clinical clinical JJ cord-023134-y665agnh 45 15 setting setting NN cord-023134-y665agnh 45 16 . . . cord-023134-y665agnh 46 1 Objective objective NN cord-023134-y665agnh 46 2 : : : cord-023134-y665agnh 47 1 Compare compare VB cord-023134-y665agnh 47 2 two two CD cord-023134-y665agnh 47 3 non non JJ cord-023134-y665agnh 47 4 - - JJ cord-023134-y665agnh 47 5 invasive invasive JJ cord-023134-y665agnh 47 6 blood blood NN cord-023134-y665agnh 47 7 pressure pressure NN cord-023134-y665agnh 47 8 ( ( -LRB- cord-023134-y665agnh 47 9 NIBP NIBP NNP cord-023134-y665agnh 47 10 ) ) -RRB- cord-023134-y665agnh 47 11 measurement measurement NN cord-023134-y665agnh 47 12 devices device NNS cord-023134-y665agnh 47 13 ( ( -LRB- cord-023134-y665agnh 47 14 petMAP petmap NN cord-023134-y665agnh 47 15 and and CC cord-023134-y665agnh 47 16 Doppler Doppler NNP cord-023134-y665agnh 47 17 ) ) -RRB- cord-023134-y665agnh 47 18 with with IN cord-023134-y665agnh 47 19 invasive invasive JJ cord-023134-y665agnh 47 20 blood blood NN cord-023134-y665agnh 47 21 pressure pressure NN cord-023134-y665agnh 47 22 ( ( -LRB- cord-023134-y665agnh 47 23 IBP IBP NNP cord-023134-y665agnh 47 24 ) ) -RRB- cord-023134-y665agnh 47 25 measurement measurement NN cord-023134-y665agnh 47 26 in in IN cord-023134-y665agnh 47 27 normotensive normotensive NNP cord-023134-y665agnh 47 28 , , , cord-023134-y665agnh 47 29 anesthetised anesthetised JJ cord-023134-y665agnh 47 30 and and CC cord-023134-y665agnh 47 31 awaken awaken VBP cord-023134-y665agnh 47 32 dogs dog NNS cord-023134-y665agnh 47 33 . . . cord-023134-y665agnh 48 1 Design design NN cord-023134-y665agnh 48 2 : : : cord-023134-y665agnh 49 1 Prospective prospective JJ cord-023134-y665agnh 49 2 clinical clinical JJ cord-023134-y665agnh 49 3 study study NN cord-023134-y665agnh 49 4 Animals animal NNS cord-023134-y665agnh 49 5 : : : cord-023134-y665agnh 49 6 Ten ten CD cord-023134-y665agnh 49 7 female female JJ cord-023134-y665agnh 49 8 dogs dog NNS cord-023134-y665agnh 49 9 aged age VBN cord-023134-y665agnh 49 10 between between IN cord-023134-y665agnh 49 11 6 6 CD cord-023134-y665agnh 49 12 to to TO cord-023134-y665agnh 49 13 60 60 CD cord-023134-y665agnh 49 14 months month NNS cord-023134-y665agnh 49 15 ( ( -LRB- cord-023134-y665agnh 49 16 average average JJ cord-023134-y665agnh 49 17 20.7 20.7 CD cord-023134-y665agnh 49 18 months month NNS cord-023134-y665agnh 49 19 ) ) -RRB- cord-023134-y665agnh 49 20 , , , cord-023134-y665agnh 49 21 and and CC cord-023134-y665agnh 49 22 weighting weight VBG cord-023134-y665agnh 49 23 12.8 12.8 CD cord-023134-y665agnh 49 24 to to IN cord-023134-y665agnh 49 25 34.2 34.2 CD cord-023134-y665agnh 49 26 kg kg NNS cord-023134-y665agnh 49 27 ( ( -LRB- cord-023134-y665agnh 49 28 average average JJ cord-023134-y665agnh 49 29 23.4 23.4 CD cord-023134-y665agnh 49 30 kg kg NNS cord-023134-y665agnh 49 31 ) ) -RRB- cord-023134-y665agnh 49 32 undergoing undergo VBG cord-023134-y665agnh 49 33 a a DT cord-023134-y665agnh 49 34 routine routine JJ cord-023134-y665agnh 49 35 spay spay NN cord-023134-y665agnh 49 36 . . . cord-023134-y665agnh 50 1 Interventions intervention NNS cord-023134-y665agnh 50 2 : : : cord-023134-y665agnh 50 3 Blood blood NN cord-023134-y665agnh 50 4 pressure pressure NN cord-023134-y665agnh 50 5 measurement measurement NN cord-023134-y665agnh 50 6 Procedures procedure NNS cord-023134-y665agnh 50 7 : : : cord-023134-y665agnh 51 1 After after IN cord-023134-y665agnh 51 2 the the DT cord-023134-y665agnh 51 3 induction induction NN cord-023134-y665agnh 51 4 of of IN cord-023134-y665agnh 51 5 general general JJ cord-023134-y665agnh 51 6 anesthesia anesthesia NNP cord-023134-y665agnh 51 7 , , , cord-023134-y665agnh 51 8 a a DT cord-023134-y665agnh 51 9 catheter catheter NN cord-023134-y665agnh 51 10 ( ( -LRB- cord-023134-y665agnh 51 11 20 20 CD cord-023134-y665agnh 51 12 G g NN cord-023134-y665agnh 51 13 ) ) -RRB- cord-023134-y665agnh 51 14 was be VBD cord-023134-y665agnh 51 15 placed place VBN cord-023134-y665agnh 51 16 in in IN cord-023134-y665agnh 51 17 the the DT cord-023134-y665agnh 51 18 dorsal dorsal JJ cord-023134-y665agnh 51 19 pedal pedal NN cord-023134-y665agnh 51 20 artery artery NN cord-023134-y665agnh 51 21 and and CC cord-023134-y665agnh 51 22 invasive invasive JJ cord-023134-y665agnh 51 23 systolic systolic JJ cord-023134-y665agnh 51 24 ( ( -LRB- cord-023134-y665agnh 51 25 SAP SAP NNP cord-023134-y665agnh 51 26 i i CD cord-023134-y665agnh 51 27 ) ) -RRB- cord-023134-y665agnh 51 28 , , , cord-023134-y665agnh 51 29 diastolic diastolic JJ cord-023134-y665agnh 51 30 ( ( -LRB- cord-023134-y665agnh 51 31 DAP DAP NNP cord-023134-y665agnh 51 32 i i NNP cord-023134-y665agnh 51 33 ) ) -RRB- cord-023134-y665agnh 51 34 and and CC cord-023134-y665agnh 51 35 mean mean VBP cord-023134-y665agnh 51 36 ( ( -LRB- cord-023134-y665agnh 51 37 MAP MAP NNP cord-023134-y665agnh 51 38 i i CD cord-023134-y665agnh 51 39 ) ) -RRB- cord-023134-y665agnh 51 40 arterial arterial JJ cord-023134-y665agnh 51 41 blood blood NN cord-023134-y665agnh 51 42 pressures pressure NNS cord-023134-y665agnh 51 43 were be VBD cord-023134-y665agnh 51 44 obtained obtain VBN cord-023134-y665agnh 51 45 . . . cord-023134-y665agnh 52 1 The the DT cord-023134-y665agnh 52 2 NIBP NIBP NNP cord-023134-y665agnh 52 3 cuffs cuff NNS cord-023134-y665agnh 52 4 were be VBD cord-023134-y665agnh 52 5 placed place VBN cord-023134-y665agnh 52 6 on on IN cord-023134-y665agnh 52 7 the the DT cord-023134-y665agnh 52 8 ipsilateral ipsilateral JJ cord-023134-y665agnh 52 9 front front JJ cord-023134-y665agnh 52 10 limb limb NN cord-023134-y665agnh 52 11 . . . cord-023134-y665agnh 53 1 Five five CD cord-023134-y665agnh 53 2 consecutive consecutive JJ cord-023134-y665agnh 53 3 measurements measurement NNS cord-023134-y665agnh 53 4 were be VBD cord-023134-y665agnh 53 5 obtained obtain VBN cord-023134-y665agnh 53 6 with with IN cord-023134-y665agnh 53 7 each each DT cord-023134-y665agnh 53 8 indirect indirect JJ cord-023134-y665agnh 53 9 device device NN cord-023134-y665agnh 53 10 and and CC cord-023134-y665agnh 53 11 considered consider VBN cord-023134-y665agnh 53 12 as as IN cord-023134-y665agnh 53 13 a a DT cord-023134-y665agnh 53 14 mean mean JJ cord-023134-y665agnh 53 15 measure measure NN cord-023134-y665agnh 53 16 . . . cord-023134-y665agnh 54 1 The the DT cord-023134-y665agnh 54 2 IBP IBP NNP cord-023134-y665agnh 54 3 was be VBD cord-023134-y665agnh 54 4 obtained obtain VBN cord-023134-y665agnh 54 5 simultaneously simultaneously RB cord-023134-y665agnh 54 6 to to IN cord-023134-y665agnh 54 7 the the DT cord-023134-y665agnh 54 8 five five CD cord-023134-y665agnh 54 9 NIBP NIBP NNP cord-023134-y665agnh 54 10 measurements measurement NNS cord-023134-y665agnh 54 11 and and CC cord-023134-y665agnh 54 12 also also RB cord-023134-y665agnh 54 13 considered consider VBN cord-023134-y665agnh 54 14 as as IN cord-023134-y665agnh 54 15 a a DT cord-023134-y665agnh 54 16 mean mean JJ cord-023134-y665agnh 54 17 measurement measurement NN cord-023134-y665agnh 54 18 . . . cord-023134-y665agnh 55 1 Measurements measurement NNS cord-023134-y665agnh 55 2 on on IN cord-023134-y665agnh 55 3 awaken awaken JJ cord-023134-y665agnh 55 4 dogs dog NNS cord-023134-y665agnh 55 5 were be VBD cord-023134-y665agnh 55 6 obtained obtain VBN cord-023134-y665agnh 55 7 four four CD cord-023134-y665agnh 55 8 hours hour NNS cord-023134-y665agnh 55 9 after after IN cord-023134-y665agnh 55 10 surgery surgery NN cord-023134-y665agnh 55 11 . . . cord-023134-y665agnh 56 1 Doppler Doppler NNP cord-023134-y665agnh 56 2 's 's POS cord-023134-y665agnh 56 3 systolic systolic JJ cord-023134-y665agnh 56 4 ( ( -LRB- cord-023134-y665agnh 56 5 SAP SAP NNP cord-023134-y665agnh 56 6 d d NNP cord-023134-y665agnh 56 7 ) ) -RRB- cord-023134-y665agnh 56 8 and and CC cord-023134-y665agnh 56 9 petMAP petmap NN cord-023134-y665agnh 56 10 's 's POS cord-023134-y665agnh 56 11 systolic systolic JJ cord-023134-y665agnh 56 12 ( ( -LRB- cord-023134-y665agnh 56 13 SAP SAP NNP cord-023134-y665agnh 56 14 o o NNP cord-023134-y665agnh 56 15 ) ) -RRB- cord-023134-y665agnh 56 16 , , , cord-023134-y665agnh 56 17 diastolic diastolic JJ cord-023134-y665agnh 56 18 ( ( -LRB- cord-023134-y665agnh 56 19 DAP DAP NNP cord-023134-y665agnh 56 20 o o NNP cord-023134-y665agnh 56 21 ) ) -RRB- cord-023134-y665agnh 56 22 and and CC cord-023134-y665agnh 57 1 mean mean VB cord-023134-y665agnh 57 2 ( ( -LRB- cord-023134-y665agnh 57 3 MAP MAP NNP cord-023134-y665agnh 57 4 o o CD cord-023134-y665agnh 57 5 ) ) -RRB- cord-023134-y665agnh 57 6 arterial arterial JJ cord-023134-y665agnh 57 7 blood blood NN cord-023134-y665agnh 57 8 pressure pressure NN cord-023134-y665agnh 57 9 were be VBD cord-023134-y665agnh 57 10 evaluated evaluate VBN cord-023134-y665agnh 57 11 and and CC cord-023134-y665agnh 57 12 compared compare VBN cord-023134-y665agnh 57 13 to to IN cord-023134-y665agnh 57 14 the the DT cord-023134-y665agnh 57 15 corresponding corresponding JJ cord-023134-y665agnh 57 16 IBP IBP NNP cord-023134-y665agnh 57 17 using use VBG cord-023134-y665agnh 57 18 the the DT cord-023134-y665agnh 57 19 Bland Bland NNP cord-023134-y665agnh 57 20 - - HYPH cord-023134-y665agnh 57 21 Altman Altman NNP cord-023134-y665agnh 57 22 analysis analysis NN cord-023134-y665agnh 57 23 . . . cord-023134-y665agnh 58 1 The the DT cord-023134-y665agnh 58 2 percentage percentage NN cord-023134-y665agnh 58 3 of of IN cord-023134-y665agnh 58 4 paired pair VBN cord-023134-y665agnh 58 5 measurements measurement NNS cord-023134-y665agnh 58 6 with with IN cord-023134-y665agnh 58 7 a a DT cord-023134-y665agnh 58 8 mean mean JJ cord-023134-y665agnh 58 9 difference difference NN cord-023134-y665agnh 58 10 of of IN cord-023134-y665agnh 58 11 10 10 CD cord-023134-y665agnh 58 12 and and CC cord-023134-y665agnh 58 13 20 20 CD cord-023134-y665agnh 58 14 mmHg mmHg NNS cord-023134-y665agnh 58 15 was be VBD cord-023134-y665agnh 58 16 also also RB cord-023134-y665agnh 58 17 evaluated evaluate VBN cord-023134-y665agnh 58 18 for for IN cord-023134-y665agnh 58 19 the the DT cord-023134-y665agnh 58 20 SAP SAP NNP cord-023134-y665agnh 58 21 o o NNP cord-023134-y665agnh 58 22 , , , cord-023134-y665agnh 58 23 DAP DAP NNP cord-023134-y665agnh 58 24 o o UH cord-023134-y665agnh 58 25 and and CC cord-023134-y665agnh 58 26 SAP SAP NNP cord-023134-y665agnh 58 27 d d NNP cord-023134-y665agnh 58 28 . . . cord-023134-y665agnh 59 1 Results result NNS cord-023134-y665agnh 59 2 : : : cord-023134-y665agnh 60 1 Agreement agreement NN cord-023134-y665agnh 60 2 between between IN cord-023134-y665agnh 60 3 IBP IBP NNP cord-023134-y665agnh 60 4 and and CC cord-023134-y665agnh 60 5 NIBP NIBP NNP cord-023134-y665agnh 60 6 measurements measurement NNS cord-023134-y665agnh 60 7 obtained obtain VBN cord-023134-y665agnh 60 8 with with IN cord-023134-y665agnh 60 9 the the DT cord-023134-y665agnh 60 10 petMAP petmap NN cord-023134-y665agnh 60 11 and and CC cord-023134-y665agnh 60 12 the the DT cord-023134-y665agnh 60 13 Doppler Doppler NNP cord-023134-y665agnh 60 14 was be VBD cord-023134-y665agnh 60 15 assessed assess VBN cord-023134-y665agnh 60 16 with with IN cord-023134-y665agnh 60 17 the the DT cord-023134-y665agnh 60 18 Bland Bland NNP cord-023134-y665agnh 60 19 - - HYPH cord-023134-y665agnh 60 20 Altman Altman NNP cord-023134-y665agnh 60 21 analysis analysis NN cord-023134-y665agnh 60 22 . . . cord-023134-y665agnh 61 1 On on IN cord-023134-y665agnh 61 2 anesthetised anesthetised JJ cord-023134-y665agnh 61 3 dogs dog NNS cord-023134-y665agnh 61 4 , , , cord-023134-y665agnh 61 5 both both DT cord-023134-y665agnh 61 6 indirect indirect JJ cord-023134-y665agnh 61 7 devices device NNS cord-023134-y665agnh 61 8 underestimated underestimate VBD cord-023134-y665agnh 61 9 all all DT cord-023134-y665agnh 61 10 direct direct JJ cord-023134-y665agnh 61 11 blood blood NN cord-023134-y665agnh 61 12 pressures pressure NNS cord-023134-y665agnh 61 13 . . . cord-023134-y665agnh 62 1 The the DT cord-023134-y665agnh 62 2 petMAP petmap NN cord-023134-y665agnh 62 3 bias bias NN cord-023134-y665agnh 62 4 ( ( -LRB- cord-023134-y665agnh 62 5 standard standard JJ cord-023134-y665agnh 62 6 deviation deviation NN cord-023134-y665agnh 62 7 ) ) -RRB- cord-023134-y665agnh 62 8 were be VBD cord-023134-y665agnh 62 9 -6.1 -6.1 HYPH cord-023134-y665agnh 62 10 mmHg mmHg NNS cord-023134-y665agnh 62 11 ( ( -LRB- cord-023134-y665agnh 62 12 10.4 10.4 CD cord-023134-y665agnh 62 13 mmHg mmHg NNPS cord-023134-y665agnh 62 14 ) ) -RRB- cord-023134-y665agnh 62 15 , , , cord-023134-y665agnh 62 16 -6.9 -6.9 NN cord-023134-y665agnh 62 17 mmHg mmhg NN cord-023134-y665agnh 62 18 ( ( -LRB- cord-023134-y665agnh 62 19 6.7 6.7 CD cord-023134-y665agnh 62 20 mmHg mmHg NNS cord-023134-y665agnh 62 21 ) ) -RRB- cord-023134-y665agnh 62 22 , , , cord-023134-y665agnh 62 23 and and CC cord-023134-y665agnh 62 24 -2.9 -2.9 NN cord-023134-y665agnh 62 25 mmHg mmHg NNS cord-023134-y665agnh 62 26 ( ( -LRB- cord-023134-y665agnh 62 27 9.3 9.3 CD cord-023134-y665agnh 62 28 mmHg mmHg NNS cord-023134-y665agnh 62 29 ) ) -RRB- cord-023134-y665agnh 62 30 for for IN cord-023134-y665agnh 62 31 SAP SAP NNP cord-023134-y665agnh 62 32 o o NNP cord-023134-y665agnh 62 33 , , , cord-023134-y665agnh 62 34 DAP DAP NNP cord-023134-y665agnh 62 35 o o UH cord-023134-y665agnh 62 36 and and CC cord-023134-y665agnh 62 37 MAP map NN cord-023134-y665agnh 62 38 o o NN cord-023134-y665agnh 62 39 respectively respectively RB cord-023134-y665agnh 62 40 . . . cord-023134-y665agnh 63 1 The the DT cord-023134-y665agnh 63 2 Doppler Doppler NNP cord-023134-y665agnh 63 3 bias bias NN cord-023134-y665agnh 63 4 was be VBD cord-023134-y665agnh 63 5 -4.1 -4.1 : cord-023134-y665agnh 63 6 mmHg mmHg NNP cord-023134-y665agnh 63 7 ( ( -LRB- cord-023134-y665agnh 63 8 24.7 24.7 CD cord-023134-y665agnh 63 9 mmHg mmHg NNS cord-023134-y665agnh 63 10 ) ) -RRB- cord-023134-y665agnh 63 11 for for IN cord-023134-y665agnh 63 12 SAP SAP NNP cord-023134-y665agnh 63 13 d d NNP cord-023134-y665agnh 63 14 . . . cord-023134-y665agnh 64 1 On on IN cord-023134-y665agnh 64 2 awaken awaken JJ cord-023134-y665agnh 64 3 dogs dog NNS cord-023134-y665agnh 64 4 , , , cord-023134-y665agnh 64 5 the the DT cord-023134-y665agnh 64 6 petMAP petmap NN cord-023134-y665agnh 64 7 underestimated underestimate VBD cord-023134-y665agnh 64 8 SAP SAP NNP cord-023134-y665agnh 64 9 i i NNP cord-023134-y665agnh 64 10 and and CC cord-023134-y665agnh 64 11 overestimated overestimate VBD cord-023134-y665agnh 64 12 DAP DAP NNP cord-023134-y665agnh 64 13 i i NNP cord-023134-y665agnh 64 14 and and CC cord-023134-y665agnh 64 15 MAP MAP NNP cord-023134-y665agnh 64 16 i i PRP cord-023134-y665agnh 64 17 . . . cord-023134-y665agnh 65 1 The the DT cord-023134-y665agnh 65 2 bias bias NN cord-023134-y665agnh 65 3 were be VBD cord-023134-y665agnh 65 4 -5.8 -5.8 : cord-023134-y665agnh 65 5 mmHg mmhg NN cord-023134-y665agnh 65 6 ( ( -LRB- cord-023134-y665agnh 65 7 16.5 16.5 CD cord-023134-y665agnh 65 8 mmHg mmHg NNPS cord-023134-y665agnh 65 9 ) ) -RRB- cord-023134-y665agnh 65 10 , , , cord-023134-y665agnh 65 11 4.6 4.6 CD cord-023134-y665agnh 65 12 mmHg mmHg NNS cord-023134-y665agnh 65 13 ( ( -LRB- cord-023134-y665agnh 65 14 7.9 7.9 CD cord-023134-y665agnh 65 15 mmHg mmHg NNPS cord-023134-y665agnh 65 16 ) ) -RRB- cord-023134-y665agnh 65 17 and and CC cord-023134-y665agnh 65 18 3.8 3.8 CD cord-023134-y665agnh 65 19 mmHg mmHg NNS cord-023134-y665agnh 65 20 ( ( -LRB- cord-023134-y665agnh 65 21 8.9 8.9 CD cord-023134-y665agnh 65 22 mmHg mmHg NNS cord-023134-y665agnh 65 23 ) ) -RRB- cord-023134-y665agnh 65 24 for for IN cord-023134-y665agnh 65 25 SAP SAP NNP cord-023134-y665agnh 65 26 o o NNP cord-023134-y665agnh 65 27 , , , cord-023134-y665agnh 65 28 DAP DAP NNP cord-023134-y665agnh 65 29 o o UH cord-023134-y665agnh 65 30 and and CC cord-023134-y665agnh 65 31 MAP map NN cord-023134-y665agnh 65 32 o o NN cord-023134-y665agnh 65 33 respectively respectively RB cord-023134-y665agnh 65 34 . . . cord-023134-y665agnh 66 1 The the DT cord-023134-y665agnh 66 2 Doppler Doppler NNP cord-023134-y665agnh 66 3 underestimated underestimate VBD cord-023134-y665agnh 66 4 the the DT cord-023134-y665agnh 66 5 IBP IBP NNP cord-023134-y665agnh 66 6 and and CC cord-023134-y665agnh 66 7 the the DT cord-023134-y665agnh 66 8 bias bias NN cord-023134-y665agnh 66 9 was be VBD cord-023134-y665agnh 66 10 -15.1 -15.1 CD cord-023134-y665agnh 66 11 mmHg mmHg NNS cord-023134-y665agnh 66 12 ( ( -LRB- cord-023134-y665agnh 66 13 21.6 21.6 CD cord-023134-y665agnh 66 14 mmHg).On mmhg).on RB cord-023134-y665agnh 66 15 anesthetised anesthetised JJ cord-023134-y665agnh 66 16 and and CC cord-023134-y665agnh 66 17 awaken awaken VBP cord-023134-y665agnh 66 18 patients patient NNS cord-023134-y665agnh 66 19 , , , cord-023134-y665agnh 66 20 the the DT cord-023134-y665agnh 66 21 percentage percentage NN cord-023134-y665agnh 66 22 of of IN cord-023134-y665agnh 66 23 values value NNS cord-023134-y665agnh 66 24 lying lie VBG cord-023134-y665agnh 66 25 within within IN cord-023134-y665agnh 66 26 10 10 CD cord-023134-y665agnh 66 27 and and CC cord-023134-y665agnh 66 28 20 20 CD cord-023134-y665agnh 66 29 mmHg mmHg NNS cord-023134-y665agnh 66 30 of of IN cord-023134-y665agnh 66 31 the the DT cord-023134-y665agnh 66 32 IBP IBP NNP cord-023134-y665agnh 66 33 was be VBD cord-023134-y665agnh 66 34 higher high JJR cord-023134-y665agnh 66 35 ( ( -LRB- cord-023134-y665agnh 66 36 or or CC cord-023134-y665agnh 66 37 equal equal JJ cord-023134-y665agnh 66 38 ) ) -RRB- cord-023134-y665agnh 66 39 for for IN cord-023134-y665agnh 66 40 the the DT cord-023134-y665agnh 66 41 petMAP petmap NN cord-023134-y665agnh 66 42 compared compare VBN cord-023134-y665agnh 66 43 to to IN cord-023134-y665agnh 66 44 the the DT cord-023134-y665agnh 66 45 Doppler Doppler NNP cord-023134-y665agnh 66 46 . . . cord-023134-y665agnh 67 1 Conclusion conclusion NN cord-023134-y665agnh 67 2 : : : cord-023134-y665agnh 68 1 Results result NNS cord-023134-y665agnh 68 2 suggest suggest VBP cord-023134-y665agnh 68 3 a a DT cord-023134-y665agnh 68 4 better well JJR cord-023134-y665agnh 68 5 performance performance NN cord-023134-y665agnh 68 6 of of IN cord-023134-y665agnh 68 7 petMAP petmap NN cord-023134-y665agnh 68 8 device device NN cord-023134-y665agnh 68 9 to to TO cord-023134-y665agnh 68 10 predict predict VB cord-023134-y665agnh 68 11 the the DT cord-023134-y665agnh 68 12 IBP IBP NNP cord-023134-y665agnh 68 13 in in IN cord-023134-y665agnh 68 14 normotensive normotensive JJ cord-023134-y665agnh 68 15 - - HYPH cord-023134-y665agnh 68 16 anesthetised anesthetised JJ cord-023134-y665agnh 68 17 and and CC cord-023134-y665agnh 68 18 normotensive normotensive RB cord-023134-y665agnh 68 19 - - HYPH cord-023134-y665agnh 68 20 awaken awaken VBN cord-023134-y665agnh 68 21 dogs dog NNS cord-023134-y665agnh 68 22 . . . cord-023134-y665agnh 69 1 Intracranial intracranial JJ cord-023134-y665agnh 69 2 hypertension hypertension NN cord-023134-y665agnh 69 3 ( ( -LRB- cord-023134-y665agnh 69 4 ICH ICH NNP cord-023134-y665agnh 69 5 ) ) -RRB- cord-023134-y665agnh 69 6 is be VBZ cord-023134-y665agnh 69 7 associated associate VBN cord-023134-y665agnh 69 8 with with IN cord-023134-y665agnh 69 9 high high JJ cord-023134-y665agnh 69 10 morbidity morbidity NN cord-023134-y665agnh 69 11 and and CC cord-023134-y665agnh 69 12 mortality mortality NN cord-023134-y665agnh 69 13 in in IN cord-023134-y665agnh 69 14 canine canine JJ cord-023134-y665agnh 69 15 veterinary veterinary JJ cord-023134-y665agnh 69 16 medicine medicine NN cord-023134-y665agnh 69 17 , , , cord-023134-y665agnh 69 18 yet yet CC cord-023134-y665agnh 69 19 remains remain VBZ cord-023134-y665agnh 69 20 difficult difficult JJ cord-023134-y665agnh 69 21 to to TO cord-023134-y665agnh 69 22 clinically clinically RB cord-023134-y665agnh 69 23 diagnose diagnose VB cord-023134-y665agnh 69 24 . . . cord-023134-y665agnh 70 1 The the DT cord-023134-y665agnh 70 2 lack lack NN cord-023134-y665agnh 70 3 of of IN cord-023134-y665agnh 70 4 an an DT cord-023134-y665agnh 70 5 easily easily RB cord-023134-y665agnh 70 6 feasible feasible JJ cord-023134-y665agnh 70 7 and and CC cord-023134-y665agnh 70 8 available available JJ cord-023134-y665agnh 70 9 diagnostic diagnostic JJ cord-023134-y665agnh 70 10 method method NN cord-023134-y665agnh 70 11 has have VBZ cord-023134-y665agnh 70 12 prevented prevent VBN cord-023134-y665agnh 70 13 clinical clinical JJ cord-023134-y665agnh 70 14 studies study NNS cord-023134-y665agnh 70 15 on on IN cord-023134-y665agnh 70 16 the the DT cord-023134-y665agnh 70 17 prevalence prevalence NN cord-023134-y665agnh 70 18 , , , cord-023134-y665agnh 70 19 cause cause NN cord-023134-y665agnh 70 20 and and CC cord-023134-y665agnh 70 21 treatment treatment NN cord-023134-y665agnh 70 22 of of IN cord-023134-y665agnh 70 23 ICH ICH NNP cord-023134-y665agnh 70 24 . . . cord-023134-y665agnh 71 1 Recently recently RB cord-023134-y665agnh 71 2 , , , cord-023134-y665agnh 71 3 transcranial transcranial JJ cord-023134-y665agnh 71 4 Doppler doppler NN cord-023134-y665agnh 71 5 ultrasonography ultrasonography NN cord-023134-y665agnh 71 6 ( ( -LRB- cord-023134-y665agnh 71 7 TCD TCD NNP cord-023134-y665agnh 71 8 ) ) -RRB- cord-023134-y665agnh 71 9 has have VBZ cord-023134-y665agnh 71 10 been be VBN cord-023134-y665agnh 71 11 reported report VBN cord-023134-y665agnh 71 12 as as IN cord-023134-y665agnh 71 13 a a DT cord-023134-y665agnh 71 14 noninvasive noninvasive JJ cord-023134-y665agnh 71 15 diagnostic diagnostic JJ cord-023134-y665agnh 71 16 method method NN cord-023134-y665agnh 71 17 in in IN cord-023134-y665agnh 71 18 humans human NNS cord-023134-y665agnh 71 19 . . . cord-023134-y665agnh 72 1 However however RB cord-023134-y665agnh 72 2 , , , cord-023134-y665agnh 72 3 only only RB cord-023134-y665agnh 72 4 a a DT cord-023134-y665agnh 72 5 few few JJ cord-023134-y665agnh 72 6 preliminary preliminary JJ cord-023134-y665agnh 72 7 reports report NNS cord-023134-y665agnh 72 8 on on IN cord-023134-y665agnh 72 9 the the DT cord-023134-y665agnh 72 10 use use NN cord-023134-y665agnh 72 11 of of IN cord-023134-y665agnh 72 12 this this DT cord-023134-y665agnh 72 13 technique technique NN cord-023134-y665agnh 72 14 in in IN cord-023134-y665agnh 72 15 dogs dog NNS cord-023134-y665agnh 72 16 have have VBP cord-023134-y665agnh 72 17 been be VBN cord-023134-y665agnh 72 18 published publish VBN cord-023134-y665agnh 72 19 . . . cord-023134-y665agnh 73 1 This this DT cord-023134-y665agnh 73 2 study study NN cord-023134-y665agnh 73 3 evaluated evaluate VBD cord-023134-y665agnh 73 4 the the DT cord-023134-y665agnh 73 5 repeatability repeatability NN cord-023134-y665agnh 73 6 and and CC cord-023134-y665agnh 73 7 reproducibility reproducibility NN cord-023134-y665agnh 73 8 of of IN cord-023134-y665agnh 73 9 TCD TCD NNP cord-023134-y665agnh 73 10 of of IN cord-023134-y665agnh 73 11 the the DT cord-023134-y665agnh 73 12 basilar basilar NN cord-023134-y665agnh 73 13 and and CC cord-023134-y665agnh 73 14 left left JJ cord-023134-y665agnh 73 15 and and CC cord-023134-y665agnh 73 16 right right JJ cord-023134-y665agnh 73 17 cranial cranial JJ cord-023134-y665agnh 73 18 , , , cord-023134-y665agnh 73 19 cerebral cerebral JJ cord-023134-y665agnh 73 20 arteries artery NNS cord-023134-y665agnh 73 21 in in IN cord-023134-y665agnh 73 22 healthy healthy JJ cord-023134-y665agnh 73 23 Beagle Beagle NNP cord-023134-y665agnh 73 24 dogs dog NNS cord-023134-y665agnh 73 25 . . . cord-023134-y665agnh 74 1 TCD TCD NNP cord-023134-y665agnh 74 2 was be VBD cord-023134-y665agnh 74 3 performed perform VBN cord-023134-y665agnh 74 4 using use VBG cord-023134-y665agnh 74 5 a a DT cord-023134-y665agnh 74 6 standard standard JJ cord-023134-y665agnh 74 7 ultrasound ultrasound NN cord-023134-y665agnh 74 8 machine machine NN cord-023134-y665agnh 74 9 at at IN cord-023134-y665agnh 74 10 the the DT cord-023134-y665agnh 74 11 level level NN cord-023134-y665agnh 74 12 of of IN cord-023134-y665agnh 74 13 the the DT cord-023134-y665agnh 74 14 basilar basilar JJ cord-023134-y665agnh 74 15 artery artery NN cord-023134-y665agnh 74 16 , , , cord-023134-y665agnh 74 17 and and CC cord-023134-y665agnh 74 18 left left JJ cord-023134-y665agnh 74 19 and and CC cord-023134-y665agnh 74 20 right right JJ cord-023134-y665agnh 74 21 cranial cranial JJ cord-023134-y665agnh 74 22 cerebral cerebral JJ cord-023134-y665agnh 74 23 artery artery NN cord-023134-y665agnh 74 24 , , , cord-023134-y665agnh 74 25 in in IN cord-023134-y665agnh 74 26 six six CD cord-023134-y665agnh 74 27 adult adult NN cord-023134-y665agnh 74 28 Beagle Beagle NNP cord-023134-y665agnh 74 29 dogs dog NNS cord-023134-y665agnh 74 30 . . . cord-023134-y665agnh 75 1 Systolic systolic JJ cord-023134-y665agnh 75 2 , , , cord-023134-y665agnh 75 3 diastolic diastolic JJ cord-023134-y665agnh 75 4 and and CC cord-023134-y665agnh 75 5 average average JJ cord-023134-y665agnh 75 6 velocity velocity NN cord-023134-y665agnh 75 7 , , , cord-023134-y665agnh 75 8 resistance resistance NN cord-023134-y665agnh 75 9 ( ( -LRB- cord-023134-y665agnh 75 10 RI RI NNP cord-023134-y665agnh 75 11 ) ) -RRB- cord-023134-y665agnh 75 12 and and CC cord-023134-y665agnh 75 13 pulsatility pulsatility NN cord-023134-y665agnh 75 14 indexes index NNS cord-023134-y665agnh 75 15 ( ( -LRB- cord-023134-y665agnh 75 16 PI PI NNP cord-023134-y665agnh 75 17 ) ) -RRB- cord-023134-y665agnh 75 18 were be VBD cord-023134-y665agnh 75 19 assessed assess VBN cord-023134-y665agnh 75 20 for for IN cord-023134-y665agnh 75 21 each each DT cord-023134-y665agnh 75 22 vessel vessel NN cord-023134-y665agnh 75 23 . . . cord-023134-y665agnh 76 1 Repeatability Repeatability NNP cord-023134-y665agnh 76 2 was be VBD cord-023134-y665agnh 76 3 evaluated evaluate VBN cord-023134-y665agnh 76 4 by by IN cord-023134-y665agnh 76 5 calculating calculate VBG cord-023134-y665agnh 76 6 the the DT cord-023134-y665agnh 76 7 intra intra JJ cord-023134-y665agnh 76 8 - - JJ cord-023134-y665agnh 76 9 class class JJ cord-023134-y665agnh 76 10 correlation correlation NN cord-023134-y665agnh 76 11 coefficient coefficient NN cord-023134-y665agnh 76 12 ( ( -LRB- cord-023134-y665agnh 76 13 ICC ICC NNP cord-023134-y665agnh 76 14 ) ) -RRB- cord-023134-y665agnh 76 15 between between IN cord-023134-y665agnh 76 16 three three CD cord-023134-y665agnh 76 17 separate separate JJ cord-023134-y665agnh 76 18 , , , cord-023134-y665agnh 76 19 consecutive consecutive JJ cord-023134-y665agnh 76 20 measurements measurement NNS cord-023134-y665agnh 76 21 in in IN cord-023134-y665agnh 76 22 every every DT cord-023134-y665agnh 76 23 dog dog NN cord-023134-y665agnh 76 24 . . . cord-023134-y665agnh 77 1 An an DT cord-023134-y665agnh 77 2 ICC ICC NNP cord-023134-y665agnh 77 3 was be VBD cord-023134-y665agnh 77 4 also also RB cord-023134-y665agnh 77 5 determined determine VBN cord-023134-y665agnh 77 6 for for IN cord-023134-y665agnh 77 7 the the DT cord-023134-y665agnh 77 8 reproducibility reproducibility NN cord-023134-y665agnh 77 9 of of IN cord-023134-y665agnh 77 10 these these DT cord-023134-y665agnh 77 11 measurements measurement NNS cord-023134-y665agnh 77 12 on on IN cord-023134-y665agnh 77 13 three three CD cord-023134-y665agnh 77 14 consecutive consecutive JJ cord-023134-y665agnh 77 15 days day NNS cord-023134-y665agnh 77 16 . . . cord-023134-y665agnh 78 1 During during IN cord-023134-y665agnh 78 2 the the DT cord-023134-y665agnh 78 3 procedures procedure NNS cord-023134-y665agnh 78 4 , , , cord-023134-y665agnh 78 5 ECG ECG NNP cord-023134-y665agnh 78 6 , , , cord-023134-y665agnh 78 7 blood blood NN cord-023134-y665agnh 78 8 pressure pressure NN cord-023134-y665agnh 78 9 and and CC cord-023134-y665agnh 78 10 clinical clinical JJ cord-023134-y665agnh 78 11 parameters parameter NNS cord-023134-y665agnh 78 12 were be VBD cord-023134-y665agnh 78 13 monitored monitor VBN cord-023134-y665agnh 78 14 . . . cord-023134-y665agnh 79 1 Statistical statistical JJ cord-023134-y665agnh 79 2 analysis analysis NN cord-023134-y665agnh 79 3 showed show VBD cord-023134-y665agnh 79 4 a a DT cord-023134-y665agnh 79 5 highly highly RB cord-023134-y665agnh 79 6 significant significant JJ cord-023134-y665agnh 79 7 repeatability repeatability NN cord-023134-y665agnh 79 8 of of IN cord-023134-y665agnh 79 9 all all DT cord-023134-y665agnh 79 10 measured measure VBN cord-023134-y665agnh 79 11 parameters parameter NNS cord-023134-y665agnh 79 12 ( ( -LRB- cord-023134-y665agnh 79 13 systolic systolic JJ cord-023134-y665agnh 79 14 , , , cord-023134-y665agnh 79 15 diastolic diastolic JJ cord-023134-y665agnh 79 16 and and CC cord-023134-y665agnh 79 17 average average JJ cord-023134-y665agnh 79 18 velocity velocity NN cord-023134-y665agnh 79 19 , , , cord-023134-y665agnh 79 20 RI RI NNP cord-023134-y665agnh 79 21 and and CC cord-023134-y665agnh 79 22 PI PI NNP cord-023134-y665agnh 79 23 ) ) -RRB- cord-023134-y665agnh 79 24 for for IN cord-023134-y665agnh 79 25 all all DT cord-023134-y665agnh 79 26 blood blood NN cord-023134-y665agnh 79 27 vessels vessel NNS cord-023134-y665agnh 79 28 ( ( -LRB- cord-023134-y665agnh 79 29 N n NN cord-023134-y665agnh 79 30 = = SYM cord-023134-y665agnh 79 31 162 162 CD cord-023134-y665agnh 79 32 , , , cord-023134-y665agnh 79 33 ICC ICC NNP cord-023134-y665agnh 79 34 = = SYM cord-023134-y665agnh 79 35 0.89 0.89 CD cord-023134-y665agnh 79 36 -0.99 -0.99 SYM cord-023134-y665agnh 79 37 , , , cord-023134-y665agnh 79 38 p p NN cord-023134-y665agnh 79 39 < < XX cord-023134-y665agnh 79 40 0.01 0.01 CD cord-023134-y665agnh 79 41 ) ) -RRB- cord-023134-y665agnh 79 42 . . . cord-023134-y665agnh 80 1 Systolic systolic JJ cord-023134-y665agnh 80 2 velocity velocity NN cord-023134-y665agnh 80 3 , , , cord-023134-y665agnh 80 4 RI RI NNP cord-023134-y665agnh 80 5 and and CC cord-023134-y665agnh 80 6 PI PI NNP cord-023134-y665agnh 80 7 were be VBD cord-023134-y665agnh 80 8 also also RB cord-023134-y665agnh 80 9 significantly significantly RB cord-023134-y665agnh 80 10 reproducible reproducible JJ cord-023134-y665agnh 80 11 for for IN cord-023134-y665agnh 80 12 the the DT cord-023134-y665agnh 80 13 basilar basilar JJ cord-023134-y665agnh 80 14 artery artery NN cord-023134-y665agnh 80 15 ( ( -LRB- cord-023134-y665agnh 80 16 N n NN cord-023134-y665agnh 80 17 = = SYM cord-023134-y665agnh 80 18 36 36 CD cord-023134-y665agnh 80 19 , , , cord-023134-y665agnh 80 20 ICC ICC NNP cord-023134-y665agnh 80 21 = = SYM cord-023134-y665agnh 80 22 0.80 0.80 CD cord-023134-y665agnh 80 23 -0.90 -0.90 NNS cord-023134-y665agnh 80 24 , , , cord-023134-y665agnh 80 25 p p NN cord-023134-y665agnh 80 26 < < XX cord-023134-y665agnh 80 27 0.01 0.01 CD cord-023134-y665agnh 80 28 ) ) -RRB- cord-023134-y665agnh 80 29 , , , cord-023134-y665agnh 80 30 and and CC cord-023134-y665agnh 80 31 the the DT cord-023134-y665agnh 80 32 left left JJ cord-023134-y665agnh 80 33 and and CC cord-023134-y665agnh 80 34 right right JJ cord-023134-y665agnh 80 35 cranial cranial JJ cord-023134-y665agnh 80 36 cerebral cerebral JJ cord-023134-y665agnh 80 37 arteries artery NNS cord-023134-y665agnh 80 38 ( ( -LRB- cord-023134-y665agnh 80 39 N n NN cord-023134-y665agnh 80 40 = = SYM cord-023134-y665agnh 80 41 72 72 CD cord-023134-y665agnh 80 42 , , , cord-023134-y665agnh 80 43 ICC ICC NNP cord-023134-y665agnh 80 44 = = SYM cord-023134-y665agnh 80 45 0.65 0.65 CD cord-023134-y665agnh 80 46 -0.74 -0.74 CD cord-023134-y665agnh 80 47 , , , cord-023134-y665agnh 80 48 p p NN cord-023134-y665agnh 80 49 < < XX cord-023134-y665agnh 80 50 0.01 0.01 CD cord-023134-y665agnh 80 51 ) ) -RRB- cord-023134-y665agnh 80 52 . . . cord-023134-y665agnh 81 1 However however RB cord-023134-y665agnh 81 2 , , , cord-023134-y665agnh 81 3 no no DT cord-023134-y665agnh 81 4 significant significant JJ cord-023134-y665agnh 81 5 correlation correlation NN cord-023134-y665agnh 81 6 was be VBD cord-023134-y665agnh 81 7 found find VBN cord-023134-y665agnh 81 8 between between IN cord-023134-y665agnh 81 9 basilar basilar JJ cord-023134-y665agnh 81 10 and and CC cord-023134-y665agnh 81 11 cerebral cerebral JJ cord-023134-y665agnh 81 12 blood blood NN cord-023134-y665agnh 81 13 flow flow NN cord-023134-y665agnh 81 14 velocities velocity NNS cord-023134-y665agnh 81 15 . . . cord-023134-y665agnh 82 1 Measurement measurement NN cord-023134-y665agnh 82 2 of of IN cord-023134-y665agnh 82 3 PI PI NNP cord-023134-y665agnh 82 4 and and CC cord-023134-y665agnh 82 5 RI RI NNP cord-023134-y665agnh 82 6 of of IN cord-023134-y665agnh 82 7 the the DT cord-023134-y665agnh 82 8 basal basal NN cord-023134-y665agnh 82 9 and and CC cord-023134-y665agnh 82 10 cranial cranial JJ cord-023134-y665agnh 82 11 cerebral cerebral JJ cord-023134-y665agnh 82 12 arteries artery NNS cord-023134-y665agnh 82 13 using use VBG cord-023134-y665agnh 82 14 TCD TCD NNP cord-023134-y665agnh 82 15 appeared appear VBD cord-023134-y665agnh 82 16 to to TO cord-023134-y665agnh 82 17 have have VB cord-023134-y665agnh 82 18 high high JJ cord-023134-y665agnh 82 19 intra intra JJ cord-023134-y665agnh 82 20 - - JJ cord-023134-y665agnh 82 21 operator operator JJ cord-023134-y665agnh 82 22 repeatability repeatability NN cord-023134-y665agnh 82 23 and and CC cord-023134-y665agnh 82 24 reproducibility reproducibility NN cord-023134-y665agnh 82 25 . . . cord-023134-y665agnh 83 1 However however RB cord-023134-y665agnh 83 2 , , , cord-023134-y665agnh 83 3 measurements measurement NNS cord-023134-y665agnh 83 4 performed perform VBN cord-023134-y665agnh 83 5 on on IN cord-023134-y665agnh 83 6 the the DT cord-023134-y665agnh 83 7 basilar basilar JJ cord-023134-y665agnh 83 8 artery artery NN cord-023134-y665agnh 83 9 had have VBD cord-023134-y665agnh 83 10 higher high JJR cord-023134-y665agnh 83 11 between between IN cord-023134-y665agnh 83 12 day day NN cord-023134-y665agnh 83 13 reproducibility reproducibility NN cord-023134-y665agnh 83 14 . . . cord-023134-y665agnh 84 1 Since since IN cord-023134-y665agnh 84 2 the the DT cord-023134-y665agnh 84 3 technical technical JJ cord-023134-y665agnh 84 4 skill skill NN cord-023134-y665agnh 84 5 required require VBN cord-023134-y665agnh 84 6 to to TO cord-023134-y665agnh 84 7 assess assess VB cord-023134-y665agnh 84 8 these these DT cord-023134-y665agnh 84 9 parameters parameter NNS cord-023134-y665agnh 84 10 subjectively subjectively RB cord-023134-y665agnh 84 11 appeared appear VBD cord-023134-y665agnh 84 12 to to TO cord-023134-y665agnh 84 13 be be VB cord-023134-y665agnh 84 14 less less RBR cord-023134-y665agnh 84 15 complicated complicated JJ cord-023134-y665agnh 84 16 at at IN cord-023134-y665agnh 84 17 the the DT cord-023134-y665agnh 84 18 level level NN cord-023134-y665agnh 84 19 of of IN cord-023134-y665agnh 84 20 the the DT cord-023134-y665agnh 84 21 basilar basilar JJ cord-023134-y665agnh 84 22 artery artery NN cord-023134-y665agnh 84 23 , , , cord-023134-y665agnh 84 24 TCD TCD NNP cord-023134-y665agnh 84 25 in in IN cord-023134-y665agnh 84 26 a a DT cord-023134-y665agnh 84 27 clinical clinical JJ cord-023134-y665agnh 84 28 setting setting NN cord-023134-y665agnh 84 29 is be VBZ cord-023134-y665agnh 84 30 probably probably RB cord-023134-y665agnh 84 31 advocated advocate VBN cord-023134-y665agnh 84 32 at at IN cord-023134-y665agnh 84 33 the the DT cord-023134-y665agnh 84 34 basal basal NN cord-023134-y665agnh 84 35 artery artery NN cord-023134-y665agnh 84 36 . . . cord-023134-y665agnh 85 1 In in IN cord-023134-y665agnh 85 2 conclusion conclusion NN cord-023134-y665agnh 85 3 , , , cord-023134-y665agnh 85 4 TCD TCD NNP cord-023134-y665agnh 85 5 is be VBZ cord-023134-y665agnh 85 6 characterized characterize VBN cord-023134-y665agnh 85 7 by by IN cord-023134-y665agnh 85 8 high high JJ cord-023134-y665agnh 85 9 intra intra JJ cord-023134-y665agnh 85 10 - - JJ cord-023134-y665agnh 85 11 observer observer JJ cord-023134-y665agnh 85 12 repeatability repeatability NN cord-023134-y665agnh 85 13 and and CC cord-023134-y665agnh 85 14 reproducibility reproducibility NN cord-023134-y665agnh 85 15 , , , cord-023134-y665agnh 85 16 making make VBG cord-023134-y665agnh 85 17 this this DT cord-023134-y665agnh 85 18 technique technique NN cord-023134-y665agnh 85 19 a a DT cord-023134-y665agnh 85 20 promising promising JJ cord-023134-y665agnh 85 21 tool tool NN cord-023134-y665agnh 85 22 for for IN cord-023134-y665agnh 85 23 the the DT cord-023134-y665agnh 85 24 measurement measurement NN cord-023134-y665agnh 85 25 of of IN cord-023134-y665agnh 85 26 PI PI NNP cord-023134-y665agnh 85 27 and and CC cord-023134-y665agnh 85 28 RI RI NNP cord-023134-y665agnh 85 29 , , , cord-023134-y665agnh 85 30 which which WDT cord-023134-y665agnh 85 31 have have VBP cord-023134-y665agnh 85 32 both both DT cord-023134-y665agnh 85 33 been be VBN cord-023134-y665agnh 85 34 reported report VBN cord-023134-y665agnh 85 35 to to TO cord-023134-y665agnh 85 36 be be VB cord-023134-y665agnh 85 37 correlated correlate VBN cord-023134-y665agnh 85 38 with with IN cord-023134-y665agnh 85 39 intracranial intracranial JJ cord-023134-y665agnh 85 40 pressure pressure NN cord-023134-y665agnh 85 41 . . . cord-023134-y665agnh 86 1 Intracranial intracranial JJ cord-023134-y665agnh 86 2 hypertension hypertension NN cord-023134-y665agnh 86 3 ( ( -LRB- cord-023134-y665agnh 86 4 ICH ICH NNP cord-023134-y665agnh 86 5 ) ) -RRB- cord-023134-y665agnh 86 6 is be VBZ cord-023134-y665agnh 86 7 associated associate VBN cord-023134-y665agnh 86 8 with with IN cord-023134-y665agnh 86 9 high high JJ cord-023134-y665agnh 86 10 morbidity morbidity NN cord-023134-y665agnh 86 11 and and CC cord-023134-y665agnh 86 12 mortality mortality NN cord-023134-y665agnh 86 13 in in IN cord-023134-y665agnh 86 14 canine canine JJ cord-023134-y665agnh 86 15 veterinary veterinary JJ cord-023134-y665agnh 86 16 medicine medicine NN cord-023134-y665agnh 86 17 , , , cord-023134-y665agnh 86 18 yet yet CC cord-023134-y665agnh 86 19 remains remain VBZ cord-023134-y665agnh 86 20 difficult difficult JJ cord-023134-y665agnh 86 21 to to TO cord-023134-y665agnh 86 22 clinically clinically RB cord-023134-y665agnh 86 23 diagnose diagnose VB cord-023134-y665agnh 86 24 . . . cord-023134-y665agnh 87 1 Furthermore furthermore RB cord-023134-y665agnh 87 2 , , , cord-023134-y665agnh 87 3 many many JJ cord-023134-y665agnh 87 4 patients patient NNS cord-023134-y665agnh 87 5 suspected suspect VBN cord-023134-y665agnh 87 6 to to TO cord-023134-y665agnh 87 7 suffer suffer VB cord-023134-y665agnh 87 8 from from IN cord-023134-y665agnh 87 9 ICH ICH NNP cord-023134-y665agnh 87 10 are be VBP cord-023134-y665agnh 87 11 treated treat VBN cord-023134-y665agnh 87 12 with with IN cord-023134-y665agnh 87 13 sedatives sedative NNS cord-023134-y665agnh 87 14 or or CC cord-023134-y665agnh 87 15 anticonvulsants anticonvulsant NNS cord-023134-y665agnh 87 16 . . . cord-023134-y665agnh 88 1 Besides besides IN cord-023134-y665agnh 88 2 the the DT cord-023134-y665agnh 88 3 impact impact NN cord-023134-y665agnh 88 4 of of IN cord-023134-y665agnh 88 5 these these DT cord-023134-y665agnh 88 6 molecules molecule NNS cord-023134-y665agnh 88 7 on on IN cord-023134-y665agnh 88 8 the the DT cord-023134-y665agnh 88 9 patients patient NNS cord-023134-y665agnh 88 10 ' ' POS cord-023134-y665agnh 88 11 neurological neurological JJ cord-023134-y665agnh 88 12 examination examination NN cord-023134-y665agnh 88 13 , , , cord-023134-y665agnh 88 14 they -PRON- PRP cord-023134-y665agnh 88 15 variably variably RB cord-023134-y665agnh 88 16 influence influence VBP cord-023134-y665agnh 88 17 the the DT cord-023134-y665agnh 88 18 cardiovascular cardiovascular JJ cord-023134-y665agnh 88 19 system system NN cord-023134-y665agnh 88 20 . . . cord-023134-y665agnh 89 1 This this DT cord-023134-y665agnh 89 2 study study NN cord-023134-y665agnh 89 3 evaluated evaluate VBD cord-023134-y665agnh 89 4 the the DT cord-023134-y665agnh 89 5 effect effect NN cord-023134-y665agnh 89 6 of of IN cord-023134-y665agnh 89 7 various various JJ cord-023134-y665agnh 89 8 sedatives sedative NNS cord-023134-y665agnh 89 9 and and CC cord-023134-y665agnh 89 10 anticonvulsants anticonvulsant NNS cord-023134-y665agnh 89 11 on on IN cord-023134-y665agnh 89 12 the the DT cord-023134-y665agnh 89 13 pulsatility pulsatility NN cord-023134-y665agnh 89 14 and and CC cord-023134-y665agnh 89 15 resistance resistance NN cord-023134-y665agnh 89 16 index index NN cord-023134-y665agnh 89 17 ( ( -LRB- cord-023134-y665agnh 89 18 PI PI NNP cord-023134-y665agnh 89 19 ) ) -RRB- cord-023134-y665agnh 89 20 and and CC cord-023134-y665agnh 89 21 ( ( -LRB- cord-023134-y665agnh 89 22 RI RI NNP cord-023134-y665agnh 89 23 ) ) -RRB- cord-023134-y665agnh 89 24 , , , cord-023134-y665agnh 89 25 as as IN cord-023134-y665agnh 89 26 measured measure VBN cord-023134-y665agnh 89 27 by by IN cord-023134-y665agnh 89 28 transcranial transcranial JJ cord-023134-y665agnh 89 29 Doppler doppler NN cord-023134-y665agnh 89 30 ultrasonography ultrasonography NN cord-023134-y665agnh 89 31 ( ( -LRB- cord-023134-y665agnh 89 32 TCD TCD NNP cord-023134-y665agnh 89 33 ) ) -RRB- cord-023134-y665agnh 89 34 in in IN cord-023134-y665agnh 89 35 healthy healthy JJ cord-023134-y665agnh 89 36 Beagle Beagle NNP cord-023134-y665agnh 89 37 dogs dog NNS cord-023134-y665agnh 89 38 . . . cord-023134-y665agnh 90 1 Additionally additionally RB cord-023134-y665agnh 90 2 , , , cord-023134-y665agnh 90 3 we -PRON- PRP cord-023134-y665agnh 90 4 evaluated evaluate VBD cord-023134-y665agnh 90 5 the the DT cord-023134-y665agnh 90 6 effect effect NN cord-023134-y665agnh 90 7 of of IN cord-023134-y665agnh 90 8 ivabradine ivabradine NN cord-023134-y665agnh 90 9 , , , cord-023134-y665agnh 90 10 a a DT cord-023134-y665agnh 90 11 specific specific JJ cord-023134-y665agnh 90 12 negative negative JJ cord-023134-y665agnh 90 13 chronotrope chronotrope NN cord-023134-y665agnh 90 14 , , , cord-023134-y665agnh 90 15 on on IN cord-023134-y665agnh 90 16 TCD TCD NNP cord-023134-y665agnh 90 17 findings finding NNS cord-023134-y665agnh 90 18 . . . cord-023134-y665agnh 91 1 TCD TCD NNP cord-023134-y665agnh 91 2 was be VBD cord-023134-y665agnh 91 3 performed perform VBN cord-023134-y665agnh 91 4 at at IN cord-023134-y665agnh 91 5 the the DT cord-023134-y665agnh 91 6 level level NN cord-023134-y665agnh 91 7 of of IN cord-023134-y665agnh 91 8 the the DT cord-023134-y665agnh 91 9 basilar basilar JJ cord-023134-y665agnh 91 10 artery artery NN cord-023134-y665agnh 91 11 in in IN cord-023134-y665agnh 91 12 six six CD cord-023134-y665agnh 91 13 adult adult NN cord-023134-y665agnh 91 14 , , , cord-023134-y665agnh 91 15 Beagle Beagle NNP cord-023134-y665agnh 91 16 dogs dog NNS cord-023134-y665agnh 91 17 . . . cord-023134-y665agnh 92 1 This this DT cord-023134-y665agnh 92 2 technique technique NN cord-023134-y665agnh 92 3 was be VBD cord-023134-y665agnh 92 4 performed perform VBN cord-023134-y665agnh 92 5 prior prior RB cord-023134-y665agnh 92 6 to to IN cord-023134-y665agnh 92 7 the the DT cord-023134-y665agnh 92 8 injection injection NN cord-023134-y665agnh 92 9 of of IN cord-023134-y665agnh 92 10 molecules molecule NNS cord-023134-y665agnh 92 11 ( ( -LRB- cord-023134-y665agnh 92 12 V0 v0 NN cord-023134-y665agnh 92 13 ) ) -RRB- cord-023134-y665agnh 92 14 , , , cord-023134-y665agnh 92 15 and and CC cord-023134-y665agnh 92 16 after after IN cord-023134-y665agnh 92 17 administration administration NN cord-023134-y665agnh 92 18 of of IN cord-023134-y665agnh 92 19 acepromazine acepromazine NNP cord-023134-y665agnh 92 20 ( ( -LRB- cord-023134-y665agnh 92 21 ACE ACE NNP cord-023134-y665agnh 92 22 , , , cord-023134-y665agnh 92 23 100 100 CD cord-023134-y665agnh 92 24 lg lg NNP cord-023134-y665agnh 92 25 / / SYM cord-023134-y665agnh 92 26 kg kg NNP cord-023134-y665agnh 92 27 IV IV NNP cord-023134-y665agnh 92 28 ) ) -RRB- cord-023134-y665agnh 92 29 , , , cord-023134-y665agnh 92 30 diazepam diazepam NNP cord-023134-y665agnh 92 31 ( ( -LRB- cord-023134-y665agnh 92 32 DIA DIA NNP cord-023134-y665agnh 92 33 , , , cord-023134-y665agnh 92 34 0.5 0.5 CD cord-023134-y665agnh 92 35 mg mg NNP cord-023134-y665agnh 92 36 / / SYM cord-023134-y665agnh 92 37 kg kg NNP cord-023134-y665agnh 92 38 IV IV NNP cord-023134-y665agnh 92 39 ) ) -RRB- cord-023134-y665agnh 92 40 , , , cord-023134-y665agnh 92 41 medetomidine medetomidine NNP cord-023134-y665agnh 92 42 ( ( -LRB- cord-023134-y665agnh 92 43 MED MED NNP cord-023134-y665agnh 92 44 , , , cord-023134-y665agnh 92 45 40 40 CD cord-023134-y665agnh 92 46 lg lg NNP cord-023134-y665agnh 92 47 / / SYM cord-023134-y665agnh 92 48 kg kg NNP cord-023134-y665agnh 92 49 IM IM NNP cord-023134-y665agnh 92 50 ) ) -RRB- cord-023134-y665agnh 92 51 or or CC cord-023134-y665agnh 92 52 ivabradine ivabradine FW cord-023134-y665agnh 92 53 ( ( -LRB- cord-023134-y665agnh 92 54 IVA IVA NNP cord-023134-y665agnh 92 55 , , , cord-023134-y665agnh 92 56 1 1 CD cord-023134-y665agnh 92 57 mg mg NNP cord-023134-y665agnh 92 58 / / SYM cord-023134-y665agnh 92 59 kg kg NNP cord-023134-y665agnh 92 60 IV IV NNP cord-023134-y665agnh 92 61 ) ) -RRB- cord-023134-y665agnh 92 62 . . . cord-023134-y665agnh 93 1 A a DT cord-023134-y665agnh 93 2 wash wash VB cord-023134-y665agnh 93 3 - - HYPH cord-023134-y665agnh 93 4 out out RP cord-023134-y665agnh 93 5 period period NN cord-023134-y665agnh 93 6 of of IN cord-023134-y665agnh 93 7 at at RB cord-023134-y665agnh 93 8 least least RBS cord-023134-y665agnh 93 9 24 24 CD cord-023134-y665agnh 93 10 hours hour NNS cord-023134-y665agnh 93 11 was be VBD cord-023134-y665agnh 93 12 respected respect VBN cord-023134-y665agnh 93 13 between between IN cord-023134-y665agnh 93 14 the the DT cord-023134-y665agnh 93 15 administration administration NN cord-023134-y665agnh 93 16 of of IN cord-023134-y665agnh 93 17 each each DT cord-023134-y665agnh 93 18 drug drug NN cord-023134-y665agnh 93 19 . . . cord-023134-y665agnh 94 1 During during IN cord-023134-y665agnh 94 2 the the DT cord-023134-y665agnh 94 3 procedure procedure NN cord-023134-y665agnh 94 4 , , , cord-023134-y665agnh 94 5 ECG ECG NNP cord-023134-y665agnh 94 6 , , , cord-023134-y665agnh 94 7 heart heart NN cord-023134-y665agnh 94 8 rate rate NN cord-023134-y665agnh 94 9 ( ( -LRB- cord-023134-y665agnh 94 10 HR HR NNP cord-023134-y665agnh 94 11 ) ) -RRB- cord-023134-y665agnh 94 12 and and CC cord-023134-y665agnh 94 13 blood blood NN cord-023134-y665agnh 94 14 pressure pressure NN cord-023134-y665agnh 94 15 ( ( -LRB- cord-023134-y665agnh 94 16 BP BP NNP cord-023134-y665agnh 94 17 ) ) -RRB- cord-023134-y665agnh 94 18 were be VBD cord-023134-y665agnh 94 19 monitored monitor VBN cord-023134-y665agnh 94 20 . . . cord-023134-y665agnh 95 1 Results result NNS cord-023134-y665agnh 95 2 were be VBD cord-023134-y665agnh 95 3 analyzed analyze VBN cord-023134-y665agnh 95 4 using use VBG cord-023134-y665agnh 95 5 Repeated repeat VBN cord-023134-y665agnh 95 6 Measures Measures NNP cord-023134-y665agnh 95 7 ANOVA anova NN cord-023134-y665agnh 95 8 . . . cord-023134-y665agnh 96 1 Correlations correlation NNS cord-023134-y665agnh 96 2 between between IN cord-023134-y665agnh 96 3 the the DT cord-023134-y665agnh 96 4 clinical clinical JJ cord-023134-y665agnh 96 5 parameters parameter NNS cord-023134-y665agnh 96 6 , , , cord-023134-y665agnh 96 7 and and CC cord-023134-y665agnh 96 8 PI PI NNP cord-023134-y665agnh 96 9 and and CC cord-023134-y665agnh 96 10 RI RI NNP cord-023134-y665agnh 96 11 were be VBD cord-023134-y665agnh 96 12 investigated investigate VBN cord-023134-y665agnh 96 13 using use VBG cord-023134-y665agnh 96 14 Pearson Pearson NNP cord-023134-y665agnh 96 15 's 's POS cord-023134-y665agnh 96 16 correlation correlation NN cord-023134-y665agnh 96 17 . . . cord-023134-y665agnh 97 1 Results result NNS cord-023134-y665agnh 97 2 were be VBD cord-023134-y665agnh 97 3 considered consider VBN cord-023134-y665agnh 97 4 significant significant JJ cord-023134-y665agnh 97 5 when when WRB cord-023134-y665agnh 97 6 p p NN cord-023134-y665agnh 97 7 < < XX cord-023134-y665agnh 97 8 0.05 0.05 CD cord-023134-y665agnh 97 9 . . . cord-023134-y665agnh 98 1 Significantly significantly RB cord-023134-y665agnh 98 2 lower low JJR cord-023134-y665agnh 98 3 PI pi NN cord-023134-y665agnh 98 4 and and CC cord-023134-y665agnh 98 5 RI RI NNP cord-023134-y665agnh 98 6 values value NNS cord-023134-y665agnh 98 7 [ [ -LRB- cord-023134-y665agnh 98 8 ( ( -LRB- cord-023134-y665agnh 98 9 mean mean VB cord-023134-y665agnh 98 10 PI PI NNP cord-023134-y665agnh 98 11 ; ; : cord-023134-y665agnh 98 12 95 95 CD cord-023134-y665agnh 98 13 % % NN cord-023134-y665agnh 98 14 CI CI NNP cord-023134-y665agnh 98 15 ) ) -RRB- cord-023134-y665agnh 98 16 , , , cord-023134-y665agnh 98 17 ( ( -LRB- cord-023134-y665agnh 98 18 mean mean VB cord-023134-y665agnh 98 19 RI RI NNP cord-023134-y665agnh 98 20 ; ; : cord-023134-y665agnh 98 21 95 95 CD cord-023134-y665agnh 98 22 % % NN cord-023134-y665agnh 98 23 CI CI NNP cord-023134-y665agnh 98 24 ) ) -RRB- cord-023134-y665agnh 98 25 ] ] -RRB- cord-023134-y665agnh 98 26 were be VBD cord-023134-y665agnh 98 27 obtained obtain VBN cord-023134-y665agnh 98 28 for for IN cord-023134-y665agnh 98 29 MED med NN cord-023134-y665agnh 98 30 [ [ -LRB- cord-023134-y665agnh 98 31 ( ( -LRB- cord-023134-y665agnh 98 32 0.75 0.75 CD cord-023134-y665agnh 98 33 ; ; : cord-023134-y665agnh 98 34 0.67 0.67 CD cord-023134-y665agnh 98 35 -0.83 -0.83 CD cord-023134-y665agnh 98 36 ( ( -LRB- cord-023134-y665agnh 98 37 1.85 1.85 CD cord-023134-y665agnh 98 38 ; ; : cord-023134-y665agnh 98 39 1.46 1.46 CD cord-023134-y665agnh 98 40 -2.23 -2.23 CD cord-023134-y665agnh 98 41 ) ) -RRB- cord-023134-y665agnh 98 42 ] ] -RRB- cord-023134-y665agnh 98 43 . . . cord-023134-y665agnh 99 1 PI PI NNP cord-023134-y665agnh 99 2 for for IN cord-023134-y665agnh 99 3 dogs dog NNS cord-023134-y665agnh 99 4 after after IN cord-023134-y665agnh 99 5 IVA IVA NNP cord-023134-y665agnh 99 6 was be VBD cord-023134-y665agnh 99 7 significantly significantly RB cord-023134-y665agnh 99 8 increased increase VBN cord-023134-y665agnh 99 9 compared compare VBN cord-023134-y665agnh 99 10 to to IN cord-023134-y665agnh 99 11 DIA DIA NNP cord-023134-y665agnh 99 12 , , , cord-023134-y665agnh 99 13 but but CC cord-023134-y665agnh 99 14 did do VBD cord-023134-y665agnh 99 15 not not RB cord-023134-y665agnh 99 16 differ differ VB cord-023134-y665agnh 99 17 significantly significantly RB cord-023134-y665agnh 99 18 from from IN cord-023134-y665agnh 99 19 other other JJ cord-023134-y665agnh 99 20 groups group NNS cord-023134-y665agnh 99 21 . . . cord-023134-y665agnh 100 1 HR HR NNP cord-023134-y665agnh 100 2 was be VBD cord-023134-y665agnh 100 3 significantly significantly RB cord-023134-y665agnh 100 4 lower low JJR cord-023134-y665agnh 100 5 after after IN cord-023134-y665agnh 100 6 MED MED NNP cord-023134-y665agnh 100 7 compared compare VBN cord-023134-y665agnh 100 8 to to IN cord-023134-y665agnh 100 9 other other JJ cord-023134-y665agnh 100 10 groups group NNS cord-023134-y665agnh 100 11 , , , cord-023134-y665agnh 100 12 and and CC cord-023134-y665agnh 100 13 after after IN cord-023134-y665agnh 100 14 IVA IVA NNP cord-023134-y665agnh 100 15 , , , cord-023134-y665agnh 100 16 compared compare VBN cord-023134-y665agnh 100 17 to to IN cord-023134-y665agnh 100 18 V0 v0 NN cord-023134-y665agnh 100 19 . . . cord-023134-y665agnh 101 1 BP BP NNP cord-023134-y665agnh 101 2 was be VBD cord-023134-y665agnh 101 3 significantly significantly RB cord-023134-y665agnh 101 4 lower low JJR cord-023134-y665agnh 101 5 after after IN cord-023134-y665agnh 101 6 ACE ace NN cord-023134-y665agnh 101 7 than than IN cord-023134-y665agnh 101 8 after after IN cord-023134-y665agnh 101 9 IVA IVA NNP cord-023134-y665agnh 101 10 , , , cord-023134-y665agnh 101 11 MED MED NNP cord-023134-y665agnh 101 12 or or CC cord-023134-y665agnh 101 13 on on IN cord-023134-y665agnh 101 14 V0 v0 NN cord-023134-y665agnh 101 15 . . . cord-023134-y665agnh 102 1 These these DT cord-023134-y665agnh 102 2 clinical clinical JJ cord-023134-y665agnh 102 3 parameters parameter NNS cord-023134-y665agnh 102 4 were be VBD cord-023134-y665agnh 102 5 not not RB cord-023134-y665agnh 102 6 significantly significantly RB cord-023134-y665agnh 102 7 correlated correlate VBN cord-023134-y665agnh 102 8 with with IN cord-023134-y665agnh 102 9 PI PI NNP cord-023134-y665agnh 102 10 or or CC cord-023134-y665agnh 102 11 RI RI NNP cord-023134-y665agnh 102 12 . . . cord-023134-y665agnh 103 1 DIA DIA NNP cord-023134-y665agnh 103 2 and and CC cord-023134-y665agnh 103 3 ACE ACE NNP cord-023134-y665agnh 103 4 did do VBD cord-023134-y665agnh 103 5 not not RB cord-023134-y665agnh 103 6 significantly significantly RB cord-023134-y665agnh 103 7 influence influence VB cord-023134-y665agnh 103 8 RI RI NNP cord-023134-y665agnh 103 9 or or CC cord-023134-y665agnh 103 10 PI pi NN cord-023134-y665agnh 103 11 , , , cord-023134-y665agnh 103 12 however however RB cord-023134-y665agnh 103 13 MED MED NNP cord-023134-y665agnh 103 14 significantly significantly RB cord-023134-y665agnh 103 15 decreased decrease VBD cord-023134-y665agnh 103 16 RI RI NNP cord-023134-y665agnh 103 17 and and CC cord-023134-y665agnh 103 18 PI pi NN cord-023134-y665agnh 103 19 . . . cord-023134-y665agnh 104 1 These these DT cord-023134-y665agnh 104 2 findings finding NNS cord-023134-y665agnh 104 3 agree agree VBP cord-023134-y665agnh 104 4 with with IN cord-023134-y665agnh 104 5 previous previous JJ cord-023134-y665agnh 104 6 reports report NNS cord-023134-y665agnh 104 7 describing describe VBG cord-023134-y665agnh 104 8 a a DT cord-023134-y665agnh 104 9 decrease decrease NN cord-023134-y665agnh 104 10 in in IN cord-023134-y665agnh 104 11 ICP ICP NNP cord-023134-y665agnh 104 12 provoked provoke VBN cord-023134-y665agnh 104 13 by by IN cord-023134-y665agnh 104 14 MED MED NNP cord-023134-y665agnh 104 15 , , , cord-023134-y665agnh 104 16 as as IN cord-023134-y665agnh 104 17 PI PI NNP cord-023134-y665agnh 104 18 is be VBZ cord-023134-y665agnh 104 19 positively positively RB cord-023134-y665agnh 104 20 correlated correlate VBN cord-023134-y665agnh 104 21 with with IN cord-023134-y665agnh 104 22 ICP ICP NNP cord-023134-y665agnh 104 23 . . . cord-023134-y665agnh 105 1 This this DT cord-023134-y665agnh 105 2 effect effect NN cord-023134-y665agnh 105 3 appears appear VBZ cord-023134-y665agnh 105 4 to to TO cord-023134-y665agnh 105 5 be be VB cord-023134-y665agnh 105 6 independent independent JJ cord-023134-y665agnh 105 7 of of IN cord-023134-y665agnh 105 8 the the DT cord-023134-y665agnh 105 9 effect effect NN cord-023134-y665agnh 105 10 of of IN cord-023134-y665agnh 105 11 MED MED NNP cord-023134-y665agnh 105 12 on on IN cord-023134-y665agnh 105 13 HR hr NN cord-023134-y665agnh 105 14 , , , cord-023134-y665agnh 105 15 since since IN cord-023134-y665agnh 105 16 IVA IVA NNP cord-023134-y665agnh 105 17 also also RB cord-023134-y665agnh 105 18 significantly significantly RB cord-023134-y665agnh 105 19 decreased decrease VBD cord-023134-y665agnh 105 20 HR hr NN cord-023134-y665agnh 105 21 , , , cord-023134-y665agnh 105 22 yet yet CC cord-023134-y665agnh 105 23 did do VBD cord-023134-y665agnh 105 24 not not RB cord-023134-y665agnh 105 25 significantly significantly RB cord-023134-y665agnh 105 26 affect affect VB cord-023134-y665agnh 105 27 PI PI NNP cord-023134-y665agnh 105 28 or or CC cord-023134-y665agnh 105 29 RI RI NNP cord-023134-y665agnh 105 30 . . . cord-023134-y665agnh 106 1 In in IN cord-023134-y665agnh 106 2 conclusion conclusion NN cord-023134-y665agnh 106 3 , , , cord-023134-y665agnh 106 4 blood blood NN cord-023134-y665agnh 106 5 pressure pressure NN cord-023134-y665agnh 106 6 and and CC cord-023134-y665agnh 106 7 heart heart NN cord-023134-y665agnh 106 8 rate rate NN cord-023134-y665agnh 106 9 did do VBD cord-023134-y665agnh 106 10 not not RB cord-023134-y665agnh 106 11 significantly significantly RB cord-023134-y665agnh 106 12 affect affect VB cord-023134-y665agnh 106 13 PI PI NNP cord-023134-y665agnh 106 14 and and CC cord-023134-y665agnh 106 15 RI RI NNP cord-023134-y665agnh 106 16 . . . cord-023134-y665agnh 107 1 Hypertrophic hypertrophic JJ cord-023134-y665agnh 107 2 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 107 3 ( ( -LRB- cord-023134-y665agnh 107 4 HCM HCM NNP cord-023134-y665agnh 107 5 ) ) -RRB- cord-023134-y665agnh 107 6 is be VBZ cord-023134-y665agnh 107 7 the the DT cord-023134-y665agnh 107 8 most most RBS cord-023134-y665agnh 107 9 commonly commonly RB cord-023134-y665agnh 107 10 diagnosed diagnose VBN cord-023134-y665agnh 107 11 heart heart NN cord-023134-y665agnh 107 12 disease disease NN cord-023134-y665agnh 107 13 in in IN cord-023134-y665agnh 107 14 cats cat NNS cord-023134-y665agnh 107 15 with with IN cord-023134-y665agnh 107 16 little little JJ cord-023134-y665agnh 107 17 documentation documentation NN cord-023134-y665agnh 107 18 of of IN cord-023134-y665agnh 107 19 the the DT cord-023134-y665agnh 107 20 effects effect NNS cord-023134-y665agnh 107 21 of of IN cord-023134-y665agnh 107 22 treatment treatment NN cord-023134-y665agnh 107 23 on on IN cord-023134-y665agnh 107 24 outcome outcome NN cord-023134-y665agnh 107 25 in in IN cord-023134-y665agnh 107 26 cats cat NNS cord-023134-y665agnh 107 27 with with IN cord-023134-y665agnh 107 28 preclinical preclinical JJ cord-023134-y665agnh 107 29 disease disease NN cord-023134-y665agnh 107 30 . . . cord-023134-y665agnh 108 1 Therefore therefore RB cord-023134-y665agnh 108 2 , , , cord-023134-y665agnh 108 3 this this DT cord-023134-y665agnh 108 4 prospective prospective JJ cord-023134-y665agnh 108 5 cohort cohort NN cord-023134-y665agnh 108 6 study study NN cord-023134-y665agnh 108 7 was be VBD cord-023134-y665agnh 108 8 undertaken undertake VBN cord-023134-y665agnh 108 9 to to TO cord-023134-y665agnh 108 10 evaluate evaluate VB cord-023134-y665agnh 108 11 the the DT cord-023134-y665agnh 108 12 effects effect NNS cord-023134-y665agnh 108 13 of of IN cord-023134-y665agnh 108 14 treatment treatment NN cord-023134-y665agnh 108 15 with with IN cord-023134-y665agnh 108 16 atenolol atenolol NN cord-023134-y665agnh 108 17 on on IN cord-023134-y665agnh 108 18 outcome outcome NN cord-023134-y665agnh 108 19 in in IN cord-023134-y665agnh 108 20 cats cat NNS cord-023134-y665agnh 108 21 with with IN cord-023134-y665agnh 108 22 asymptomatic asymptomatic JJ cord-023134-y665agnh 108 23 HCM HCM NNP cord-023134-y665agnh 108 24 . . . cord-023134-y665agnh 109 1 We -PRON- PRP cord-023134-y665agnh 109 2 hypothesized hypothesize VBD cord-023134-y665agnh 109 3 that that IN cord-023134-y665agnh 109 4 1 1 CD cord-023134-y665agnh 109 5 ) ) -RRB- cord-023134-y665agnh 109 6 5-year 5-year CD cord-023134-y665agnh 109 7 mortality mortality NN cord-023134-y665agnh 109 8 would would MD cord-023134-y665agnh 109 9 be be VB cord-023134-y665agnh 109 10 increased increase VBN cord-023134-y665agnh 109 11 in in IN cord-023134-y665agnh 109 12 cats cat NNS cord-023134-y665agnh 109 13 with with IN cord-023134-y665agnh 109 14 HCM HCM NNP cord-023134-y665agnh 109 15 compared compare VBN cord-023134-y665agnh 109 16 to to IN cord-023134-y665agnh 109 17 a a DT cord-023134-y665agnh 109 18 matched match VBN cord-023134-y665agnh 109 19 control control NN cord-023134-y665agnh 109 20 group group NN cord-023134-y665agnh 109 21 of of IN cord-023134-y665agnh 109 22 healthy healthy JJ cord-023134-y665agnh 109 23 cats cat NNS cord-023134-y665agnh 109 24 , , , cord-023134-y665agnh 109 25 and and CC cord-023134-y665agnh 110 1 2 2 LS cord-023134-y665agnh 110 2 ) ) -RRB- cord-023134-y665agnh 110 3 administration administration NN cord-023134-y665agnh 110 4 of of IN cord-023134-y665agnh 110 5 atenolol atenolol NNP cord-023134-y665agnh 110 6 would would MD cord-023134-y665agnh 110 7 reduce reduce VB cord-023134-y665agnh 110 8 5-year 5-year CD cord-023134-y665agnh 110 9 cardiac cardiac JJ cord-023134-y665agnh 110 10 mortality mortality NN cord-023134-y665agnh 110 11 in in IN cord-023134-y665agnh 110 12 occult occult JJ cord-023134-y665agnh 110 13 feline feline JJ cord-023134-y665agnh 110 14 HCM.Cats hcm.cat NNS cord-023134-y665agnh 110 15 were be VBD cord-023134-y665agnh 110 16 enrolled enrol VBN cord-023134-y665agnh 110 17 over over IN cord-023134-y665agnh 110 18 a a DT cord-023134-y665agnh 110 19 5-year 5-year CD cord-023134-y665agnh 110 20 time time NN cord-023134-y665agnh 110 21 period period NN cord-023134-y665agnh 110 22 ( ( -LRB- cord-023134-y665agnh 110 23 2003 2003 CD cord-023134-y665agnh 110 24 to to IN cord-023134-y665agnh 110 25 2007 2007 CD cord-023134-y665agnh 110 26 ) ) -RRB- cord-023134-y665agnh 110 27 in in IN cord-023134-y665agnh 110 28 a a DT cord-023134-y665agnh 110 29 prospective prospective JJ cord-023134-y665agnh 110 30 , , , cord-023134-y665agnh 110 31 open open JJ cord-023134-y665agnh 110 32 - - HYPH cord-023134-y665agnh 110 33 label label NN cord-023134-y665agnh 110 34 , , , cord-023134-y665agnh 110 35 observational observational JJ cord-023134-y665agnh 110 36 study study NN cord-023134-y665agnh 110 37 . . . cord-023134-y665agnh 111 1 Diagnosis diagnosis NN cord-023134-y665agnh 111 2 of of IN cord-023134-y665agnh 111 3 HCM HCM NNP cord-023134-y665agnh 111 4 was be VBD cord-023134-y665agnh 111 5 based base VBN cord-023134-y665agnh 111 6 on on IN cord-023134-y665agnh 111 7 transthoracic transthoracic NN cord-023134-y665agnh 111 8 echocardiography echocardiography NN cord-023134-y665agnh 111 9 . . . cord-023134-y665agnh 112 1 Cats cat NNS cord-023134-y665agnh 112 2 were be VBD cord-023134-y665agnh 112 3 either either RB cord-023134-y665agnh 112 4 treated treat VBN cord-023134-y665agnh 112 5 with with IN cord-023134-y665agnh 112 6 atenolol atenolol NN cord-023134-y665agnh 112 7 ( ( -LRB- cord-023134-y665agnh 112 8 6.25 6.25 CD cord-023134-y665agnh 112 9 to to IN cord-023134-y665agnh 112 10 12.5 12.5 CD cord-023134-y665agnh 112 11 mg mg NNP cord-023134-y665agnh 112 12 / / SYM cord-023134-y665agnh 112 13 cat cat NN cord-023134-y665agnh 112 14 , , , cord-023134-y665agnh 112 15 q12h q12h XX cord-023134-y665agnh 112 16 , , , cord-023134-y665agnh 112 17 PO PO NNP cord-023134-y665agnh 112 18 ) ) -RRB- cord-023134-y665agnh 112 19 or or CC cord-023134-y665agnh 112 20 did do VBD cord-023134-y665agnh 112 21 not not RB cord-023134-y665agnh 112 22 receive receive VB cord-023134-y665agnh 112 23 treatment treatment NN cord-023134-y665agnh 112 24 . . . cord-023134-y665agnh 113 1 Decision decision NN cord-023134-y665agnh 113 2 to to TO cord-023134-y665agnh 113 3 treat treat VB cord-023134-y665agnh 113 4 was be VBD cord-023134-y665agnh 113 5 based base VBN cord-023134-y665agnh 113 6 on on IN cord-023134-y665agnh 113 7 owner owner NN cord-023134-y665agnh 113 8 preference preference NN cord-023134-y665agnh 113 9 , , , cord-023134-y665agnh 113 10 suggestion suggestion NN cord-023134-y665agnh 113 11 by by IN cord-023134-y665agnh 113 12 the the DT cord-023134-y665agnh 113 13 clinician clinician NN cord-023134-y665agnh 113 14 , , , cord-023134-y665agnh 113 15 and and CC cord-023134-y665agnh 113 16 animal animal NN cord-023134-y665agnh 113 17 compliance compliance NN cord-023134-y665agnh 113 18 with with IN cord-023134-y665agnh 113 19 regard regard NN cord-023134-y665agnh 113 20 to to IN cord-023134-y665agnh 113 21 pill pill NN cord-023134-y665agnh 113 22 administration administration NN cord-023134-y665agnh 113 23 . . . cord-023134-y665agnh 114 1 Baseline baseline JJ cord-023134-y665agnh 114 2 echocardiograms echocardiogram NNS cord-023134-y665agnh 114 3 were be VBD cord-023134-y665agnh 114 4 analyzed analyze VBN cord-023134-y665agnh 114 5 , , , cord-023134-y665agnh 114 6 and and CC cord-023134-y665agnh 114 7 morbidity morbidity NN cord-023134-y665agnh 114 8 and and CC cord-023134-y665agnh 114 9 mortality mortality NN cord-023134-y665agnh 114 10 were be VBD cord-023134-y665agnh 114 11 monitored monitor VBN cord-023134-y665agnh 114 12 at at IN cord-023134-y665agnh 114 13 3 3 CD cord-023134-y665agnh 114 14 and and CC cord-023134-y665agnh 114 15 6 6 CD cord-023134-y665agnh 114 16 months month NNS cord-023134-y665agnh 114 17 and and CC cord-023134-y665agnh 114 18 thereafter thereafter RB cord-023134-y665agnh 114 19 by by IN cord-023134-y665agnh 114 20 annual annual JJ cord-023134-y665agnh 114 21 rechecks recheck NNS cord-023134-y665agnh 114 22 , , , cord-023134-y665agnh 114 23 and and CC cord-023134-y665agnh 114 24 by by IN cord-023134-y665agnh 114 25 phone phone NN cord-023134-y665agnh 114 26 interviews interview NNS cord-023134-y665agnh 114 27 of of IN cord-023134-y665agnh 114 28 referring refer VBG cord-023134-y665agnh 114 29 veterinarians veterinarian NNS cord-023134-y665agnh 114 30 and and CC cord-023134-y665agnh 114 31 owners owner NNS cord-023134-y665agnh 114 32 over over IN cord-023134-y665agnh 114 33 a a DT cord-023134-y665agnh 114 34 5-year 5-year CD cord-023134-y665agnh 114 35 time time NN cord-023134-y665agnh 114 36 period period NN cord-023134-y665agnh 114 37 . . . cord-023134-y665agnh 115 1 Groups group NNS cord-023134-y665agnh 115 2 were be VBD cord-023134-y665agnh 115 3 compared compare VBN cord-023134-y665agnh 115 4 by by IN cord-023134-y665agnh 115 5 a a DT cord-023134-y665agnh 115 6 non non JJ cord-023134-y665agnh 115 7 - - JJ cord-023134-y665agnh 115 8 paired paired JJ cord-023134-y665agnh 115 9 t t NN cord-023134-y665agnh 115 10 - - HYPH cord-023134-y665agnh 115 11 test test NN cord-023134-y665agnh 115 12 , , , cord-023134-y665agnh 115 13 Introduction introduction NN cord-023134-y665agnh 115 14 : : : cord-023134-y665agnh 115 15 Systolic systolic JJ cord-023134-y665agnh 115 16 anterior anterior JJ cord-023134-y665agnh 115 17 motion motion NN cord-023134-y665agnh 115 18 of of IN cord-023134-y665agnh 115 19 the the DT cord-023134-y665agnh 115 20 mitral mitral JJ cord-023134-y665agnh 115 21 valve valve NN cord-023134-y665agnh 115 22 ( ( -LRB- cord-023134-y665agnh 115 23 SAM SAM NNP cord-023134-y665agnh 115 24 ) ) -RRB- cord-023134-y665agnh 115 25 is be VBZ cord-023134-y665agnh 115 26 a a DT cord-023134-y665agnh 115 27 dynamic dynamic JJ cord-023134-y665agnh 115 28 left leave VBN cord-023134-y665agnh 115 29 ventricular ventricular JJ cord-023134-y665agnh 115 30 outflow outflow JJ cord-023134-y665agnh 115 31 obstruction obstruction NN cord-023134-y665agnh 115 32 frequently frequently RB cord-023134-y665agnh 115 33 observed observe VBD cord-023134-y665agnh 115 34 in in IN cord-023134-y665agnh 115 35 feline feline JJ cord-023134-y665agnh 115 36 hypertrophic hypertrophic JJ cord-023134-y665agnh 115 37 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 115 38 ( ( -LRB- cord-023134-y665agnh 115 39 HCM HCM NNP cord-023134-y665agnh 115 40 ) ) -RRB- cord-023134-y665agnh 115 41 . . . cord-023134-y665agnh 116 1 However however RB cord-023134-y665agnh 116 2 , , , cord-023134-y665agnh 116 3 several several JJ cord-023134-y665agnh 116 4 cases case NNS cord-023134-y665agnh 116 5 of of IN cord-023134-y665agnh 116 6 SAM SAM NNP cord-023134-y665agnh 116 7 have have VBP cord-023134-y665agnh 116 8 also also RB cord-023134-y665agnh 116 9 been be VBN cord-023134-y665agnh 116 10 observed observe VBN cord-023134-y665agnh 116 11 in in IN cord-023134-y665agnh 116 12 cats cat NNS cord-023134-y665agnh 116 13 without without IN cord-023134-y665agnh 116 14 left leave VBN cord-023134-y665agnh 116 15 ventricular ventricular JJ cord-023134-y665agnh 116 16 hypertrophy hypertrophy NN cord-023134-y665agnh 116 17 ( ( -LRB- cord-023134-y665agnh 116 18 LVH LVH NNP cord-023134-y665agnh 116 19 ) ) -RRB- cord-023134-y665agnh 116 20 and and CC cord-023134-y665agnh 116 21 this this DT cord-023134-y665agnh 116 22 finding finding NN cord-023134-y665agnh 116 23 could could MD cord-023134-y665agnh 116 24 be be VB cord-023134-y665agnh 116 25 interpreted interpret VBN cord-023134-y665agnh 116 26 as as IN cord-023134-y665agnh 116 27 an an DT cord-023134-y665agnh 116 28 early early JJ cord-023134-y665agnh 116 29 stage stage NN cord-023134-y665agnh 116 30 of of IN cord-023134-y665agnh 116 31 the the DT cord-023134-y665agnh 116 32 disease disease NN cord-023134-y665agnh 116 33 not not RB cord-023134-y665agnh 116 34 yet yet RB cord-023134-y665agnh 116 35 accompanied accompany VBN cord-023134-y665agnh 116 36 by by IN cord-023134-y665agnh 116 37 LVH LVH NNP cord-023134-y665agnh 116 38 . . . cord-023134-y665agnh 117 1 Alternatively alternatively RB cord-023134-y665agnh 117 2 , , , cord-023134-y665agnh 117 3 it -PRON- PRP cord-023134-y665agnh 117 4 could could MD cord-023134-y665agnh 117 5 be be VB cord-023134-y665agnh 117 6 speculated speculate VBN cord-023134-y665agnh 117 7 that that IN cord-023134-y665agnh 117 8 the the DT cord-023134-y665agnh 117 9 dynamic dynamic JJ cord-023134-y665agnh 117 10 outflow outflow JJ cord-023134-y665agnh 117 11 obstruction obstruction NN cord-023134-y665agnh 117 12 could could MD cord-023134-y665agnh 117 13 cause cause VB cord-023134-y665agnh 117 14 intraventricular intraventricular JJ cord-023134-y665agnh 117 15 pressure pressure NN cord-023134-y665agnh 117 16 overload overload NN cord-023134-y665agnh 117 17 sufficient sufficient JJ cord-023134-y665agnh 117 18 enough enough RB cord-023134-y665agnh 117 19 to to TO cord-023134-y665agnh 117 20 induce induce VB cord-023134-y665agnh 117 21 LVH LVH NNP cord-023134-y665agnh 117 22 at at IN cord-023134-y665agnh 117 23 a a DT cord-023134-y665agnh 117 24 later later JJ cord-023134-y665agnh 117 25 stage stage NN cord-023134-y665agnh 117 26 . . . cord-023134-y665agnh 118 1 This this DT cord-023134-y665agnh 118 2 study study NN cord-023134-y665agnh 118 3 was be VBD cord-023134-y665agnh 118 4 conducted conduct VBN cord-023134-y665agnh 118 5 to to TO cord-023134-y665agnh 118 6 test test VB cord-023134-y665agnh 118 7 the the DT cord-023134-y665agnh 118 8 hypothesis hypothesis NN cord-023134-y665agnh 118 9 that that IN cord-023134-y665agnh 118 10 SAM SAM NNP cord-023134-y665agnh 118 11 can can MD cord-023134-y665agnh 118 12 potentially potentially RB cord-023134-y665agnh 118 13 cause cause VB cord-023134-y665agnh 118 14 myocardial myocardial JJ cord-023134-y665agnh 118 15 stress stress NN cord-023134-y665agnh 118 16 and and CC cord-023134-y665agnh 118 17 myocardial myocardial JJ cord-023134-y665agnh 118 18 damage damage NN cord-023134-y665agnh 118 19 by by IN cord-023134-y665agnh 118 20 measuring measure VBG cord-023134-y665agnh 118 21 plasma plasma NN cord-023134-y665agnh 118 22 NTproBNP NTproBNP NNP cord-023134-y665agnh 118 23 and and CC cord-023134-y665agnh 118 24 serum serum NN cord-023134-y665agnh 118 25 troponin troponin NNS cord-023134-y665agnh 118 26 - - HYPH cord-023134-y665agnh 118 27 I -PRON- PRP cord-023134-y665agnh 118 28 levels level NNS cord-023134-y665agnh 118 29 in in IN cord-023134-y665agnh 118 30 cats cat NNS cord-023134-y665agnh 118 31 with with IN cord-023134-y665agnh 118 32 SAM SAM NNP cord-023134-y665agnh 118 33 not not RB cord-023134-y665agnh 118 34 associated associate VBN cord-023134-y665agnh 118 35 with with IN cord-023134-y665agnh 118 36 LVH LVH NNP cord-023134-y665agnh 118 37 . . . cord-023134-y665agnh 119 1 Methods method NNS cord-023134-y665agnh 119 2 : : : cord-023134-y665agnh 120 1 The the DT cord-023134-y665agnh 120 2 study study NN cord-023134-y665agnh 120 3 was be VBD cord-023134-y665agnh 120 4 based base VBN cord-023134-y665agnh 120 5 on on IN cord-023134-y665agnh 120 6 a a DT cord-023134-y665agnh 120 7 retrospective retrospective JJ cord-023134-y665agnh 120 8 analysis analysis NN cord-023134-y665agnh 120 9 of of IN cord-023134-y665agnh 120 10 13 13 CD cord-023134-y665agnh 120 11 cats cat NNS cord-023134-y665agnh 120 12 who who WP cord-023134-y665agnh 120 13 underwent undergo VBD cord-023134-y665agnh 120 14 cardiac cardiac JJ cord-023134-y665agnh 120 15 investigation investigation NN cord-023134-y665agnh 120 16 of of IN cord-023134-y665agnh 120 17 a a DT cord-023134-y665agnh 120 18 heart heart NN cord-023134-y665agnh 120 19 murmur murmur NN cord-023134-y665agnh 120 20 , , , cord-023134-y665agnh 120 21 performed perform VBN cord-023134-y665agnh 120 22 by by IN cord-023134-y665agnh 120 23 a a DT cord-023134-y665agnh 120 24 boarded board VBN cord-023134-y665agnh 120 25 cardiologist cardiologist NN cord-023134-y665agnh 120 26 . . . cord-023134-y665agnh 121 1 These these DT cord-023134-y665agnh 121 2 cats cat NNS cord-023134-y665agnh 121 3 were be VBD cord-023134-y665agnh 121 4 diagnosed diagnose VBN cord-023134-y665agnh 121 5 with with IN cord-023134-y665agnh 121 6 SAM SAM NNP cord-023134-y665agnh 121 7 not not RB cord-023134-y665agnh 121 8 associated associate VBN cord-023134-y665agnh 121 9 with with IN cord-023134-y665agnh 121 10 LVH LVH NNP cord-023134-y665agnh 121 11 ( ( -LRB- cord-023134-y665agnh 121 12 IVSd IVSd NNS cord-023134-y665agnh 121 13 and and CC cord-023134-y665agnh 121 14 LVFWd LVFWd NNS cord-023134-y665agnh 121 15 < < XX cord-023134-y665agnh 121 16 5.5 5.5 CD cord-023134-y665agnh 121 17 mm mm NNS cord-023134-y665agnh 121 18 , , , cord-023134-y665agnh 121 19 both both DT cord-023134-y665agnh 121 20 on on IN cord-023134-y665agnh 121 21 Bmode Bmode NNP cord-023134-y665agnh 121 22 and and CC cord-023134-y665agnh 121 23 Mmode Mmode NNP cord-023134-y665agnh 121 24 measurements measurement NNS cord-023134-y665agnh 121 25 ) ) -RRB- cord-023134-y665agnh 121 26 via via IN cord-023134-y665agnh 121 27 colour colour NN cord-023134-y665agnh 121 28 Doppler Doppler NNP cord-023134-y665agnh 121 29 echocardiography echocardiography NN cord-023134-y665agnh 121 30 . . . cord-023134-y665agnh 122 1 Plasma plasma NN cord-023134-y665agnh 122 2 NTproBNP NTproBNP NNP cord-023134-y665agnh 122 3 ( ( -LRB- cord-023134-y665agnh 122 4 Cardiopet Cardiopet NNP cord-023134-y665agnh 122 5 test test NN cord-023134-y665agnh 122 6 , , , cord-023134-y665agnh 122 7 IDEXX IDEXX NNP cord-023134-y665agnh 122 8 Laboratories Laboratories NNP cord-023134-y665agnh 122 9 , , , cord-023134-y665agnh 122 10 Inc. Inc. NNP cord-023134-y665agnh 122 11 ) ) -RRB- cord-023134-y665agnh 122 12 and and CC cord-023134-y665agnh 122 13 serum serum NN cord-023134-y665agnh 122 14 high high JJ cord-023134-y665agnh 122 15 sensitivity sensitivity NN cord-023134-y665agnh 122 16 troponin troponin NN cord-023134-y665agnh 122 17 - - : cord-023134-y665agnh 122 18 I -PRON- PRP cord-023134-y665agnh 122 19 ( ( -LRB- cord-023134-y665agnh 123 1 hscTnI hsctni ADD cord-023134-y665agnh 123 2 HS HS NNP cord-023134-y665agnh 123 3 , , , cord-023134-y665agnh 123 4 IDEXX IDEXX NNP cord-023134-y665agnh 123 5 Laboratories Laboratories NNP cord-023134-y665agnh 123 6 , , , cord-023134-y665agnh 123 7 Inc Inc NNP cord-023134-y665agnh 123 8 ) ) -RRB- cord-023134-y665agnh 123 9 were be VBD cord-023134-y665agnh 123 10 measured measure VBN cord-023134-y665agnh 123 11 in in IN cord-023134-y665agnh 123 12 these these DT cord-023134-y665agnh 123 13 patients patient NNS cord-023134-y665agnh 123 14 , , , cord-023134-y665agnh 123 15 as as RB cord-023134-y665agnh 123 16 well well RB cord-023134-y665agnh 123 17 as as IN cord-023134-y665agnh 123 18 serum serum NN cord-023134-y665agnh 123 19 urea urea NN cord-023134-y665agnh 123 20 , , , cord-023134-y665agnh 123 21 creatinine creatinine NN cord-023134-y665agnh 123 22 and and CC cord-023134-y665agnh 123 23 thyroxin thyroxin NNP cord-023134-y665agnh 123 24 concentrations concentration NNS cord-023134-y665agnh 123 25 . . . cord-023134-y665agnh 124 1 The the DT cord-023134-y665agnh 124 2 association association NN cord-023134-y665agnh 124 3 between between IN cord-023134-y665agnh 124 4 biomarkers biomarker NNS cord-023134-y665agnh 124 5 ( ( -LRB- cord-023134-y665agnh 124 6 NTproBNP NTproBNP NNP cord-023134-y665agnh 124 7 and and CC cord-023134-y665agnh 124 8 HscTnI HscTnI NNP cord-023134-y665agnh 124 9 ) ) -RRB- cord-023134-y665agnh 124 10 concentration concentration NN cord-023134-y665agnh 124 11 and and CC cord-023134-y665agnh 124 12 echocardiographic echocardiographic JJ cord-023134-y665agnh 124 13 values value NNS cord-023134-y665agnh 124 14 ( ( -LRB- cord-023134-y665agnh 124 15 myocardial myocardial JJ cord-023134-y665agnh 124 16 thickness thickness NN cord-023134-y665agnh 124 17 , , , cord-023134-y665agnh 124 18 left leave VBN cord-023134-y665agnh 124 19 atrial atrial JJ cord-023134-y665agnh 124 20 dimension dimension NN cord-023134-y665agnh 124 21 and and CC cord-023134-y665agnh 124 22 aortic aortic JJ cord-023134-y665agnh 124 23 peak peak NN cord-023134-y665agnh 124 24 velocity velocity NN cord-023134-y665agnh 124 25 ) ) -RRB- cord-023134-y665agnh 124 26 was be VBD cord-023134-y665agnh 124 27 determined determine VBN cord-023134-y665agnh 124 28 by by IN cord-023134-y665agnh 124 29 using use VBG cord-023134-y665agnh 124 30 the the DT cord-023134-y665agnh 124 31 Spearman Spearman NNP cord-023134-y665agnh 124 32 correlation correlation NN cord-023134-y665agnh 124 33 coefficient coefficient NN cord-023134-y665agnh 124 34 ( ( -LRB- cord-023134-y665agnh 124 35 rho rho NN cord-023134-y665agnh 124 36 ) ) -RRB- cord-023134-y665agnh 124 37 . . . cord-023134-y665agnh 125 1 Results result NNS cord-023134-y665agnh 125 2 : : : cord-023134-y665agnh 126 1 All all DT cord-023134-y665agnh 126 2 cats cat NNS cord-023134-y665agnh 126 3 were be VBD cord-023134-y665agnh 126 4 euthyroid euthyroid JJ cord-023134-y665agnh 126 5 and and CC cord-023134-y665agnh 126 6 did do VBD cord-023134-y665agnh 126 7 not not RB cord-023134-y665agnh 126 8 show show VB cord-023134-y665agnh 126 9 evidence evidence NN cord-023134-y665agnh 126 10 of of IN cord-023134-y665agnh 126 11 renal renal JJ cord-023134-y665agnh 126 12 disease disease NN cord-023134-y665agnh 126 13 . . . cord-023134-y665agnh 127 1 Mean mean JJ cord-023134-y665agnh 127 2 HscTnI HscTnI NNP cord-023134-y665agnh 127 3 measurement measurement NN cord-023134-y665agnh 127 4 was be VBD cord-023134-y665agnh 127 5 not not RB cord-023134-y665agnh 127 6 performed perform VBN cord-023134-y665agnh 127 7 in in IN cord-023134-y665agnh 127 8 one one CD cord-023134-y665agnh 127 9 cat cat NN cord-023134-y665agnh 127 10 due due JJ cord-023134-y665agnh 127 11 to to IN cord-023134-y665agnh 127 12 an an DT cord-023134-y665agnh 127 13 unsuitable unsuitable JJ cord-023134-y665agnh 127 14 sample sample NN cord-023134-y665agnh 127 15 . . . cord-023134-y665agnh 128 1 Eleven eleven CD cord-023134-y665agnh 128 2 out out IN cord-023134-y665agnh 128 3 of of IN cord-023134-y665agnh 128 4 13 13 CD cord-023134-y665agnh 128 5 cats cat NNS cord-023134-y665agnh 128 6 ( ( -LRB- cord-023134-y665agnh 128 7 85 85 CD cord-023134-y665agnh 128 8 % % NN cord-023134-y665agnh 128 9 ) ) -RRB- cord-023134-y665agnh 128 10 showed show VBD cord-023134-y665agnh 128 11 NTproBNP NTproBNP NNP cord-023134-y665agnh 128 12 values value NNS cord-023134-y665agnh 128 13 above above IN cord-023134-y665agnh 128 14 the the DT cord-023134-y665agnh 128 15 normal normal JJ cord-023134-y665agnh 128 16 reference reference NN cord-023134-y665agnh 128 17 limit limit NN cord-023134-y665agnh 128 18 ( ( -LRB- cord-023134-y665agnh 128 19 100 100 CD cord-023134-y665agnh 128 20 pmol pmol NN cord-023134-y665agnh 128 21 / / SYM cord-023134-y665agnh 128 22 l l NN cord-023134-y665agnh 128 23 ) ) -RRB- cord-023134-y665agnh 128 24 with with IN cord-023134-y665agnh 128 25 a a DT cord-023134-y665agnh 128 26 median median JJ cord-023134-y665agnh 128 27 concentration concentration NN cord-023134-y665agnh 128 28 of of IN cord-023134-y665agnh 128 29 393 393 CD cord-023134-y665agnh 128 30 pmol pmol NN cord-023134-y665agnh 128 31 / / SYM cord-023134-y665agnh 128 32 l l NN cord-023134-y665agnh 128 33 ( ( -LRB- cord-023134-y665agnh 128 34 ± ± NNP cord-023134-y665agnh 128 35 194 194 CD cord-023134-y665agnh 128 36 , , , cord-023134-y665agnh 128 37 range range VBP cord-023134-y665agnh 128 38 109 109 CD cord-023134-y665agnh 128 39 - - HYPH cord-023134-y665agnh 128 40 711 711 CD cord-023134-y665agnh 128 41 ) ) -RRB- cord-023134-y665agnh 128 42 . . . cord-023134-y665agnh 129 1 Five five CD cord-023134-y665agnh 129 2 out out IN cord-023134-y665agnh 129 3 of of IN cord-023134-y665agnh 129 4 12 12 CD cord-023134-y665agnh 129 5 cats cat NNS cord-023134-y665agnh 129 6 ( ( -LRB- cord-023134-y665agnh 129 7 42 42 CD cord-023134-y665agnh 129 8 % % NN cord-023134-y665agnh 129 9 ) ) -RRB- cord-023134-y665agnh 129 10 showed show VBD cord-023134-y665agnh 129 11 HscTnI HscTnI NNP cord-023134-y665agnh 129 12 values value NNS cord-023134-y665agnh 129 13 above above IN cord-023134-y665agnh 129 14 the the DT cord-023134-y665agnh 129 15 normal normal JJ cord-023134-y665agnh 129 16 reference reference NN cord-023134-y665agnh 129 17 limit limit NN cord-023134-y665agnh 129 18 ( ( -LRB- cord-023134-y665agnh 129 19 0.16 0.16 CD cord-023134-y665agnh 129 20 ng ng NN cord-023134-y665agnh 129 21 / / SYM cord-023134-y665agnh 129 22 ml ml NNP cord-023134-y665agnh 129 23 ) ) -RRB- cord-023134-y665agnh 129 24 with with IN cord-023134-y665agnh 129 25 a a DT cord-023134-y665agnh 129 26 median median JJ cord-023134-y665agnh 129 27 concentration concentration NN cord-023134-y665agnh 129 28 of of IN cord-023134-y665agnh 129 29 0.24 0.24 CD cord-023134-y665agnh 129 30 ng ng NN cord-023134-y665agnh 129 31 / / SYM cord-023134-y665agnh 129 32 ml ml NN cord-023134-y665agnh 129 33 ( ( -LRB- cord-023134-y665agnh 129 34 ± ± NNP cord-023134-y665agnh 129 35 0.35 0.35 CD cord-023134-y665agnh 129 36 , , , cord-023134-y665agnh 129 37 range range VBP cord-023134-y665agnh 129 38 0.16 0.16 CD cord-023134-y665agnh 129 39 - - HYPH cord-023134-y665agnh 129 40 0.99 0.99 CD cord-023134-y665agnh 129 41 ) ) -RRB- cord-023134-y665agnh 129 42 . . . cord-023134-y665agnh 130 1 There there EX cord-023134-y665agnh 130 2 was be VBD cord-023134-y665agnh 130 3 a a DT cord-023134-y665agnh 130 4 significant significant JJ cord-023134-y665agnh 130 5 positive positive JJ cord-023134-y665agnh 130 6 correlation correlation NN cord-023134-y665agnh 130 7 between between IN cord-023134-y665agnh 130 8 aortic aortic JJ cord-023134-y665agnh 130 9 peak peak NN cord-023134-y665agnh 130 10 velocity velocity NN cord-023134-y665agnh 130 11 and and CC cord-023134-y665agnh 130 12 NTproBNP NTproBNP NNP cord-023134-y665agnh 130 13 ( ( -LRB- cord-023134-y665agnh 130 14 rho=0.657 rho=0.657 NNP cord-023134-y665agnh 130 15 , , , cord-023134-y665agnh 130 16 P=0.0146 P=0.0146 NNP cord-023134-y665agnh 130 17 ) ) -RRB- cord-023134-y665agnh 130 18 . . . cord-023134-y665agnh 131 1 Conclusion conclusion NN cord-023134-y665agnh 131 2 : : : cord-023134-y665agnh 131 3 NTproBNP NTproBNP NNP cord-023134-y665agnh 131 4 is be VBZ cord-023134-y665agnh 131 5 increased increase VBN cord-023134-y665agnh 131 6 in in IN cord-023134-y665agnh 131 7 cats cat NNS cord-023134-y665agnh 131 8 with with IN cord-023134-y665agnh 131 9 SAM SAM NNP cord-023134-y665agnh 131 10 without without IN cord-023134-y665agnh 131 11 LVH LVH NNP cord-023134-y665agnh 131 12 , , , cord-023134-y665agnh 131 13 suggesting suggest VBG cord-023134-y665agnh 131 14 the the DT cord-023134-y665agnh 131 15 presence presence NN cord-023134-y665agnh 131 16 of of IN cord-023134-y665agnh 131 17 myocardial myocardial JJ cord-023134-y665agnh 131 18 stress stress NN cord-023134-y665agnh 131 19 , , , cord-023134-y665agnh 131 20 which which WDT cord-023134-y665agnh 131 21 appears appear VBZ cord-023134-y665agnh 131 22 to to TO cord-023134-y665agnh 131 23 be be VB cord-023134-y665agnh 131 24 proportional proportional JJ cord-023134-y665agnh 131 25 to to IN cord-023134-y665agnh 131 26 the the DT cord-023134-y665agnh 131 27 degree degree NN cord-023134-y665agnh 131 28 of of IN cord-023134-y665agnh 131 29 outflow outflow JJ cord-023134-y665agnh 131 30 obstruction obstruction NN cord-023134-y665agnh 131 31 derived derive VBN cord-023134-y665agnh 131 32 by by IN cord-023134-y665agnh 131 33 the the DT cord-023134-y665agnh 131 34 aortic aortic JJ cord-023134-y665agnh 131 35 peak peak NN cord-023134-y665agnh 131 36 velocity velocity NN cord-023134-y665agnh 131 37 . . . cord-023134-y665agnh 132 1 Some some DT cord-023134-y665agnh 132 2 of of IN cord-023134-y665agnh 132 3 these these DT cord-023134-y665agnh 132 4 cats cat NNS cord-023134-y665agnh 132 5 also also RB cord-023134-y665agnh 132 6 present present VBP cord-023134-y665agnh 132 7 a a DT cord-023134-y665agnh 132 8 degree degree NN cord-023134-y665agnh 132 9 of of IN cord-023134-y665agnh 132 10 myocardial myocardial JJ cord-023134-y665agnh 132 11 insult insult NN cord-023134-y665agnh 132 12 suggested suggest VBN cord-023134-y665agnh 132 13 by by IN cord-023134-y665agnh 132 14 the the DT cord-023134-y665agnh 132 15 increased increase VBN cord-023134-y665agnh 132 16 serum serum NN cord-023134-y665agnh 132 17 HscTnI. HscTnI. NNP cord-023134-y665agnh 133 1 Whether whether IN cord-023134-y665agnh 133 2 the the DT cord-023134-y665agnh 133 3 increased increase VBN cord-023134-y665agnh 133 4 biomarker biomarker NN cord-023134-y665agnh 133 5 concentrations concentration NNS cord-023134-y665agnh 133 6 are be VBP cord-023134-y665agnh 133 7 related relate VBN cord-023134-y665agnh 133 8 to to IN cord-023134-y665agnh 133 9 SAM SAM NNP cord-023134-y665agnh 133 10 - - HYPH cord-023134-y665agnh 133 11 induced induce VBN cord-023134-y665agnh 133 12 pressure pressure NN cord-023134-y665agnh 133 13 overload overload NN cord-023134-y665agnh 133 14 or or CC cord-023134-y665agnh 133 15 to to IN cord-023134-y665agnh 133 16 an an DT cord-023134-y665agnh 133 17 early early JJ cord-023134-y665agnh 133 18 stage stage NN cord-023134-y665agnh 133 19 of of IN cord-023134-y665agnh 133 20 primary primary JJ cord-023134-y665agnh 133 21 myocardial myocardial JJ cord-023134-y665agnh 133 22 disease disease NN cord-023134-y665agnh 133 23 needs need VBZ cord-023134-y665agnh 133 24 to to TO cord-023134-y665agnh 133 25 be be VB cord-023134-y665agnh 133 26 evaluated evaluate VBN cord-023134-y665agnh 133 27 with with IN cord-023134-y665agnh 133 28 appropriate appropriate JJ cord-023134-y665agnh 133 29 longitudinal longitudinal JJ cord-023134-y665agnh 133 30 studies study NNS cord-023134-y665agnh 133 31 . . . cord-023134-y665agnh 134 1 Heart heart NN cord-023134-y665agnh 134 2 murmurs murmur NNS cord-023134-y665agnh 134 3 are be VBP cord-023134-y665agnh 134 4 caused cause VBN cord-023134-y665agnh 134 5 by by IN cord-023134-y665agnh 134 6 turbulent turbulent JJ cord-023134-y665agnh 134 7 blood blood NN cord-023134-y665agnh 134 8 flow flow NN cord-023134-y665agnh 134 9 or or CC cord-023134-y665agnh 134 10 by by IN cord-023134-y665agnh 134 11 vibration vibration NN cord-023134-y665agnh 134 12 of of IN cord-023134-y665agnh 134 13 cardiac cardiac JJ cord-023134-y665agnh 134 14 structures structure NNS cord-023134-y665agnh 134 15 . . . cord-023134-y665agnh 135 1 Turbulent turbulent JJ cord-023134-y665agnh 135 2 blood blood NN cord-023134-y665agnh 135 3 flow flow NN cord-023134-y665agnh 135 4 in in IN cord-023134-y665agnh 135 5 young young JJ cord-023134-y665agnh 135 6 animals animal NNS cord-023134-y665agnh 135 7 may may MD cord-023134-y665agnh 135 8 originate originate VB cord-023134-y665agnh 135 9 from from IN cord-023134-y665agnh 135 10 congenital congenital JJ cord-023134-y665agnh 135 11 structural structural JJ cord-023134-y665agnh 135 12 heart heart NN cord-023134-y665agnh 135 13 disease disease NN cord-023134-y665agnh 135 14 or or CC cord-023134-y665agnh 135 15 from from IN cord-023134-y665agnh 135 16 physiological physiological JJ cord-023134-y665agnh 135 17 phenomena phenomenon NNS cord-023134-y665agnh 135 18 . . . cord-023134-y665agnh 136 1 The the DT cord-023134-y665agnh 136 2 prevalence prevalence NN cord-023134-y665agnh 136 3 of of IN cord-023134-y665agnh 136 4 heart heart NN cord-023134-y665agnh 136 5 murmurs murmur NNS cord-023134-y665agnh 136 6 and and CC cord-023134-y665agnh 136 7 congenital congenital JJ cord-023134-y665agnh 136 8 heart heart NN cord-023134-y665agnh 136 9 disease disease NN cord-023134-y665agnh 136 10 in in IN cord-023134-y665agnh 136 11 the the DT cord-023134-y665agnh 136 12 general general JJ cord-023134-y665agnh 136 13 ( ( -LRB- cord-023134-y665agnh 136 14 i.e. i.e. FW cord-023134-y665agnh 136 15 non non FW cord-023134-y665agnh 136 16 referral referral JJ cord-023134-y665agnh 136 17 ) ) -RRB- cord-023134-y665agnh 136 18 feline feline JJ cord-023134-y665agnh 136 19 population population NN cord-023134-y665agnh 136 20 are be VBP cord-023134-y665agnh 136 21 unknown unknown JJ cord-023134-y665agnh 136 22 . . . cord-023134-y665agnh 137 1 The the DT cord-023134-y665agnh 137 2 aims aim NNS cord-023134-y665agnh 137 3 of of IN cord-023134-y665agnh 137 4 this this DT cord-023134-y665agnh 137 5 prospective prospective JJ cord-023134-y665agnh 137 6 study study NN cord-023134-y665agnh 137 7 were be VBD cord-023134-y665agnh 137 8 to to TO cord-023134-y665agnh 137 9 determine determine VB cord-023134-y665agnh 137 10 the the DT cord-023134-y665agnh 137 11 prevalence prevalence NN cord-023134-y665agnh 137 12 of of IN cord-023134-y665agnh 137 13 heart heart NN cord-023134-y665agnh 137 14 murmurs murmur NNS cord-023134-y665agnh 137 15 in in IN cord-023134-y665agnh 137 16 young young JJ cord-023134-y665agnh 137 17 cats cat NNS cord-023134-y665agnh 137 18 and and CC cord-023134-y665agnh 137 19 to to TO cord-023134-y665agnh 137 20 determine determine VB cord-023134-y665agnh 137 21 the the DT cord-023134-y665agnh 137 22 prevalence prevalence NN cord-023134-y665agnh 137 23 of of IN cord-023134-y665agnh 137 24 congenital congenital JJ cord-023134-y665agnh 137 25 heart heart NN cord-023134-y665agnh 137 26 disease disease NN cord-023134-y665agnh 137 27 in in IN cord-023134-y665agnh 137 28 young young JJ cord-023134-y665agnh 137 29 cats cat NNS cord-023134-y665agnh 137 30 with with IN cord-023134-y665agnh 137 31 heart heart NN cord-023134-y665agnh 137 32 murmurs murmur NNS cord-023134-y665agnh 137 33 . . . cord-023134-y665agnh 138 1 In in IN cord-023134-y665agnh 138 2 total total JJ cord-023134-y665agnh 138 3 2935 2935 CD cord-023134-y665agnh 138 4 domestic domestic JJ cord-023134-y665agnh 138 5 shorthair shorthair JJ cord-023134-y665agnh 138 6 cats cat NNS cord-023134-y665agnh 138 7 aged age VBN cord-023134-y665agnh 138 8 2 2 CD cord-023134-y665agnh 138 9 to to TO cord-023134-y665agnh 138 10 6 6 CD cord-023134-y665agnh 138 11 months month NNS cord-023134-y665agnh 138 12 underwent undergo VBD cord-023134-y665agnh 138 13 a a DT cord-023134-y665agnh 138 14 routine routine JJ cord-023134-y665agnh 138 15 physical physical JJ cord-023134-y665agnh 138 16 examination examination NN cord-023134-y665agnh 138 17 prior prior RB cord-023134-y665agnh 138 18 to to IN cord-023134-y665agnh 138 19 vaccination vaccination NN cord-023134-y665agnh 138 20 between between IN cord-023134-y665agnh 138 21 May May NNP cord-023134-y665agnh 138 22 1 1 CD cord-023134-y665agnh 138 23 st st NNP cord-023134-y665agnh 138 24 2009 2009 CD cord-023134-y665agnh 138 25 until until IN cord-023134-y665agnh 138 26 March March NNP cord-023134-y665agnh 138 27 31 31 CD cord-023134-y665agnh 138 28 st st NNP cord-023134-y665agnh 138 29 2012 2012 CD cord-023134-y665agnh 138 30 . . . cord-023134-y665agnh 139 1 Cats cat NNS cord-023134-y665agnh 139 2 were be VBD cord-023134-y665agnh 139 3 from from IN cord-023134-y665agnh 139 4 adoption adoption NN cord-023134-y665agnh 139 5 programs program NNS cord-023134-y665agnh 139 6 run run VBN cord-023134-y665agnh 139 7 by by IN cord-023134-y665agnh 139 8 either either CC cord-023134-y665agnh 139 9 Dierenasiel Dierenasiel NNP cord-023134-y665agnh 139 10 Breda Breda NNP cord-023134-y665agnh 139 11 e.o e.o NNP cord-023134-y665agnh 139 12 . . . cord-023134-y665agnh 140 1 ( ( -LRB- cord-023134-y665agnh 140 2 2090/2935 2090/2935 CD cord-023134-y665agnh 140 3 ) ) -RRB- cord-023134-y665agnh 140 4 or or CC cord-023134-y665agnh 140 5 Dierenopvangcentrum Dierenopvangcentrum NNP cord-023134-y665agnh 140 6 Tilburg Tilburg NNP cord-023134-y665agnh 140 7 ( ( -LRB- cord-023134-y665agnh 140 8 845/2935 845/2935 CD cord-023134-y665agnh 140 9 ) ) -RRB- cord-023134-y665agnh 140 10 . . . cord-023134-y665agnh 141 1 In in IN cord-023134-y665agnh 141 2 cats cat NNS cord-023134-y665agnh 141 3 with with IN cord-023134-y665agnh 141 4 murmurs murmur NNS cord-023134-y665agnh 141 5 , , , cord-023134-y665agnh 141 6 the the DT cord-023134-y665agnh 141 7 murmur murmur NN cord-023134-y665agnh 141 8 was be VBD cord-023134-y665agnh 141 9 timed time VBN cord-023134-y665agnh 141 10 , , , cord-023134-y665agnh 141 11 graded grade VBN cord-023134-y665agnh 141 12 and and CC cord-023134-y665agnh 141 13 the the DT cord-023134-y665agnh 141 14 point point NN cord-023134-y665agnh 141 15 of of IN cord-023134-y665agnh 141 16 maximum maximum JJ cord-023134-y665agnh 141 17 intensity intensity NN cord-023134-y665agnh 141 18 was be VBD cord-023134-y665agnh 141 19 determined determine VBN cord-023134-y665agnh 141 20 . . . cord-023134-y665agnh 142 1 Subsequently subsequently RB cord-023134-y665agnh 142 2 , , , cord-023134-y665agnh 142 3 2D 2D NNP cord-023134-y665agnh 142 4 , , , cord-023134-y665agnh 142 5 M M NNP cord-023134-y665agnh 142 6 - - HYPH cord-023134-y665agnh 142 7 mode mode NNP cord-023134-y665agnh 142 8 and and CC cord-023134-y665agnh 142 9 Doppler Doppler NNP cord-023134-y665agnh 142 10 transthoracic transthoracic NN cord-023134-y665agnh 142 11 echocardiography echocardiography NN cord-023134-y665agnh 142 12 with with IN cord-023134-y665agnh 142 13 continuous continuous JJ cord-023134-y665agnh 142 14 ecg ecg NNP cord-023134-y665agnh 142 15 monitoring monitoring NN cord-023134-y665agnh 142 16 was be VBD cord-023134-y665agnh 142 17 performed perform VBN cord-023134-y665agnh 142 18 . . . cord-023134-y665agnh 143 1 Heart heart NN cord-023134-y665agnh 143 2 murmurs murmur NNS cord-023134-y665agnh 143 3 were be VBD cord-023134-y665agnh 143 4 detected detect VBN cord-023134-y665agnh 143 5 in in IN cord-023134-y665agnh 143 6 135 135 CD cord-023134-y665agnh 143 7 animals animal NNS cord-023134-y665agnh 143 8 ( ( -LRB- cord-023134-y665agnh 143 9 4.6 4.6 CD cord-023134-y665agnh 143 10 % % NN cord-023134-y665agnh 143 11 ) ) -RRB- cord-023134-y665agnh 143 12 . . . cord-023134-y665agnh 144 1 Congenital congenital JJ cord-023134-y665agnh 144 2 heart heart NN cord-023134-y665agnh 144 3 disease disease NN cord-023134-y665agnh 144 4 was be VBD cord-023134-y665agnh 144 5 detected detect VBN cord-023134-y665agnh 144 6 in in IN cord-023134-y665agnh 144 7 47 47 CD cord-023134-y665agnh 144 8 animals animal NNS cord-023134-y665agnh 144 9 ( ( -LRB- cord-023134-y665agnh 144 10 1.6 1.6 CD cord-023134-y665agnh 144 11 % % NN cord-023134-y665agnh 144 12 ) ) -RRB- cord-023134-y665agnh 144 13 , , , cord-023134-y665agnh 144 14 acquired acquire VBD cord-023134-y665agnh 144 15 heart heart NN cord-023134-y665agnh 144 16 disease disease NN cord-023134-y665agnh 144 17 in in IN cord-023134-y665agnh 144 18 2 2 CD cord-023134-y665agnh 144 19 animals animal NNS cord-023134-y665agnh 144 20 ( ( -LRB- cord-023134-y665agnh 144 21 0.06 0.06 CD cord-023134-y665agnh 144 22 % % NN cord-023134-y665agnh 144 23 ) ) -RRB- cord-023134-y665agnh 144 24 and and CC cord-023134-y665agnh 144 25 no no DT cord-023134-y665agnh 144 26 identifiable identifiable JJ cord-023134-y665agnh 144 27 heart heart NN cord-023134-y665agnh 144 28 disease disease NN cord-023134-y665agnh 144 29 in in IN cord-023134-y665agnh 144 30 86 86 CD cord-023134-y665agnh 144 31 animals animal NNS cord-023134-y665agnh 144 32 ( ( -LRB- cord-023134-y665agnh 144 33 2.9 2.9 CD cord-023134-y665agnh 144 34 % % NN cord-023134-y665agnh 144 35 ) ) -RRB- cord-023134-y665agnh 144 36 with with IN cord-023134-y665agnh 144 37 murmurs murmur NNS cord-023134-y665agnh 144 38 . . . cord-023134-y665agnh 145 1 In in IN cord-023134-y665agnh 145 2 the the DT cord-023134-y665agnh 145 3 86 86 CD cord-023134-y665agnh 145 4 animals animal NNS cord-023134-y665agnh 145 5 without without IN cord-023134-y665agnh 145 6 heart heart NN cord-023134-y665agnh 145 7 disease disease NN cord-023134-y665agnh 145 8 dynamic dynamic JJ cord-023134-y665agnh 145 9 right right JJ cord-023134-y665agnh 145 10 ventricular ventricular JJ cord-023134-y665agnh 145 11 outflow outflow JJ cord-023134-y665agnh 145 12 tract tract JJ cord-023134-y665agnh 145 13 obstruction obstruction NN cord-023134-y665agnh 145 14 was be VBD cord-023134-y665agnh 145 15 the the DT cord-023134-y665agnh 145 16 cause cause NN cord-023134-y665agnh 145 17 of of IN cord-023134-y665agnh 145 18 the the DT cord-023134-y665agnh 145 19 murmur murmur NN cord-023134-y665agnh 145 20 in in IN cord-023134-y665agnh 145 21 2 2 CD cord-023134-y665agnh 145 22 cases case NNS cord-023134-y665agnh 145 23 , , , cord-023134-y665agnh 145 24 turbulence turbulence NN cord-023134-y665agnh 145 25 within within IN cord-023134-y665agnh 145 26 the the DT cord-023134-y665agnh 145 27 left left JJ cord-023134-y665agnh 145 28 ventricle ventricle NN cord-023134-y665agnh 145 29 was be VBD cord-023134-y665agnh 145 30 the the DT cord-023134-y665agnh 145 31 cause cause NN cord-023134-y665agnh 145 32 in in IN cord-023134-y665agnh 145 33 6 6 CD cord-023134-y665agnh 145 34 cases case NNS cord-023134-y665agnh 145 35 . . . cord-023134-y665agnh 146 1 In in IN cord-023134-y665agnh 146 2 2 2 CD cord-023134-y665agnh 146 3 animals animal NNS cord-023134-y665agnh 146 4 with with IN cord-023134-y665agnh 146 5 acquired acquire VBN cord-023134-y665agnh 146 6 heart heart NN cord-023134-y665agnh 146 7 disease disease NN cord-023134-y665agnh 146 8 , , , cord-023134-y665agnh 146 9 pulmonary pulmonary JJ cord-023134-y665agnh 146 10 hypertension hypertension NN cord-023134-y665agnh 146 11 associated associate VBN cord-023134-y665agnh 146 12 with with IN cord-023134-y665agnh 146 13 A. A. NNP cord-023134-y665agnh 146 14 abstrusus abstrusus NNP cord-023134-y665agnh 146 15 was be VBD cord-023134-y665agnh 146 16 diagnosed diagnose VBN cord-023134-y665agnh 146 17 . . . cord-023134-y665agnh 147 1 In in IN cord-023134-y665agnh 147 2 the the DT cord-023134-y665agnh 147 3 47 47 CD cord-023134-y665agnh 147 4 cats cat NNS cord-023134-y665agnh 147 5 with with IN cord-023134-y665agnh 147 6 congenital congenital JJ cord-023134-y665agnh 147 7 heart heart NN cord-023134-y665agnh 147 8 disease disease NN cord-023134-y665agnh 147 9 , , , cord-023134-y665agnh 147 10 isolated isolate VBN cord-023134-y665agnh 147 11 defects defect NNS cord-023134-y665agnh 147 12 were be VBD cord-023134-y665agnh 147 13 found find VBN cord-023134-y665agnh 147 14 in in IN cord-023134-y665agnh 147 15 38 38 CD cord-023134-y665agnh 147 16 cats cat NNS cord-023134-y665agnh 147 17 , , , cord-023134-y665agnh 147 18 being be VBG cord-023134-y665agnh 147 19 tricuspid tricuspid JJ cord-023134-y665agnh 147 20 valve valve NN cord-023134-y665agnh 147 21 dysplasia dysplasia NN cord-023134-y665agnh 147 22 in in IN cord-023134-y665agnh 147 23 19 19 CD cord-023134-y665agnh 147 24 cats cat NNS cord-023134-y665agnh 147 25 , , , cord-023134-y665agnh 147 26 dynamic dynamic JJ cord-023134-y665agnh 147 27 left leave VBN cord-023134-y665agnh 147 28 ventricular ventricular JJ cord-023134-y665agnh 147 29 outflow outflow JJ cord-023134-y665agnh 147 30 tract tract JJ cord-023134-y665agnh 147 31 obstruction obstruction NN cord-023134-y665agnh 147 32 associated associate VBN cord-023134-y665agnh 147 33 with with IN cord-023134-y665agnh 147 34 mitral mitral JJ cord-023134-y665agnh 147 35 valve valve NN cord-023134-y665agnh 147 36 dysplasia dysplasia NN cord-023134-y665agnh 147 37 in in IN cord-023134-y665agnh 147 38 13 13 CD cord-023134-y665agnh 147 39 cats cat NNS cord-023134-y665agnh 147 40 , , , cord-023134-y665agnh 147 41 ventricular ventricular JJ cord-023134-y665agnh 147 42 septal septal JJ cord-023134-y665agnh 147 43 defects defect NNS cord-023134-y665agnh 147 44 in in IN cord-023134-y665agnh 147 45 3 3 CD cord-023134-y665agnh 147 46 cats cat NNS cord-023134-y665agnh 147 47 , , , cord-023134-y665agnh 147 48 double double JJ cord-023134-y665agnh 147 49 chambered chambered JJ cord-023134-y665agnh 147 50 right right JJ cord-023134-y665agnh 147 51 ventricle ventricle NN cord-023134-y665agnh 147 52 in in IN cord-023134-y665agnh 147 53 2 2 CD cord-023134-y665agnh 147 54 cats cat NNS cord-023134-y665agnh 147 55 and and CC cord-023134-y665agnh 147 56 pulmonic pulmonic JJ cord-023134-y665agnh 147 57 stenosis stenosis NN cord-023134-y665agnh 147 58 in in IN cord-023134-y665agnh 147 59 1 1 CD cord-023134-y665agnh 147 60 cat cat NN cord-023134-y665agnh 147 61 . . . cord-023134-y665agnh 148 1 Combination combination NN cord-023134-y665agnh 148 2 defects defect NNS cord-023134-y665agnh 148 3 were be VBD cord-023134-y665agnh 148 4 found find VBN cord-023134-y665agnh 148 5 in in IN cord-023134-y665agnh 148 6 9 9 CD cord-023134-y665agnh 148 7 cats cat NNS cord-023134-y665agnh 148 8 , , , cord-023134-y665agnh 148 9 being be VBG cord-023134-y665agnh 148 10 ventricular ventricular JJ cord-023134-y665agnh 148 11 septal septal JJ cord-023134-y665agnh 148 12 defect defect NN cord-023134-y665agnh 148 13 and and CC cord-023134-y665agnh 148 14 tricuspid tricuspid NN cord-023134-y665agnh 148 15 valve valve NN cord-023134-y665agnh 148 16 dysplasia dysplasia NN cord-023134-y665agnh 148 17 in in IN cord-023134-y665agnh 148 18 3 3 CD cord-023134-y665agnh 148 19 , , , cord-023134-y665agnh 148 20 ventricular ventricular JJ cord-023134-y665agnh 148 21 septal septal JJ cord-023134-y665agnh 148 22 defects defect NNS cord-023134-y665agnh 148 23 and and CC cord-023134-y665agnh 148 24 double double JJ cord-023134-y665agnh 148 25 chambered chambered JJ cord-023134-y665agnh 148 26 right right JJ cord-023134-y665agnh 148 27 ventricle ventricle NN cord-023134-y665agnh 148 28 in in IN cord-023134-y665agnh 148 29 2 2 CD cord-023134-y665agnh 148 30 , , , cord-023134-y665agnh 148 31 ventricular ventricular JJ cord-023134-y665agnh 148 32 septal septal JJ cord-023134-y665agnh 148 33 defect defect NN cord-023134-y665agnh 148 34 and and CC cord-023134-y665agnh 148 35 atrial atrial JJ cord-023134-y665agnh 148 36 septal septal JJ cord-023134-y665agnh 148 37 defect defect NN cord-023134-y665agnh 148 38 in in IN cord-023134-y665agnh 148 39 1 1 CD cord-023134-y665agnh 148 40 cat cat NN cord-023134-y665agnh 148 41 , , , cord-023134-y665agnh 148 42 a a DT cord-023134-y665agnh 148 43 ventricular ventricular JJ cord-023134-y665agnh 148 44 septal septal JJ cord-023134-y665agnh 148 45 defect defect NN cord-023134-y665agnh 148 46 and and CC cord-023134-y665agnh 148 47 pulmonic pulmonic JJ cord-023134-y665agnh 148 48 stenosis stenosis NN cord-023134-y665agnh 148 49 in in IN cord-023134-y665agnh 148 50 1 1 CD cord-023134-y665agnh 148 51 cat cat NN cord-023134-y665agnh 148 52 and and CC cord-023134-y665agnh 148 53 mitral mitral JJ cord-023134-y665agnh 148 54 and and CC cord-023134-y665agnh 148 55 tricuspid tricuspid JJ cord-023134-y665agnh 148 56 valve valve NN cord-023134-y665agnh 148 57 dysplasia dysplasia NN cord-023134-y665agnh 148 58 in in IN cord-023134-y665agnh 148 59 2 2 CD cord-023134-y665agnh 148 60 cats cat NNS cord-023134-y665agnh 148 61 . . . cord-023134-y665agnh 149 1 In in IN cord-023134-y665agnh 149 2 conclusion conclusion NN cord-023134-y665agnh 149 3 in in IN cord-023134-y665agnh 149 4 this this DT cord-023134-y665agnh 149 5 prospective prospective JJ cord-023134-y665agnh 149 6 study study NN cord-023134-y665agnh 149 7 we -PRON- PRP cord-023134-y665agnh 149 8 found find VBD cord-023134-y665agnh 149 9 the the DT cord-023134-y665agnh 149 10 prevalence prevalence NN cord-023134-y665agnh 149 11 of of IN cord-023134-y665agnh 149 12 heart heart NN cord-023134-y665agnh 149 13 murmurs murmur VBZ cord-023134-y665agnh 149 14 to to TO cord-023134-y665agnh 149 15 be be VB cord-023134-y665agnh 149 16 4.6 4.6 CD cord-023134-y665agnh 149 17 % % NN cord-023134-y665agnh 149 18 and and CC cord-023134-y665agnh 149 19 the the DT cord-023134-y665agnh 149 20 prevalence prevalence NN cord-023134-y665agnh 149 21 of of IN cord-023134-y665agnh 149 22 congenital congenital JJ cord-023134-y665agnh 149 23 heart heart NN cord-023134-y665agnh 149 24 disease disease NN cord-023134-y665agnh 149 25 to to TO cord-023134-y665agnh 149 26 be be VB cord-023134-y665agnh 149 27 1.6 1.6 CD cord-023134-y665agnh 149 28 % % NN cord-023134-y665agnh 149 29 with with IN cord-023134-y665agnh 149 30 atrioventricular atrioventricular JJ cord-023134-y665agnh 149 31 valve valve NN cord-023134-y665agnh 149 32 abnormalities abnormality NNS cord-023134-y665agnh 149 33 and and CC cord-023134-y665agnh 149 34 ventricular ventricular JJ cord-023134-y665agnh 149 35 septal septal JJ cord-023134-y665agnh 149 36 defects defect NNS cord-023134-y665agnh 149 37 being be VBG cord-023134-y665agnh 149 38 the the DT cord-023134-y665agnh 149 39 most most RBS cord-023134-y665agnh 149 40 common common JJ cord-023134-y665agnh 149 41 . . . cord-023134-y665agnh 150 1 Dynamic dynamic JJ cord-023134-y665agnh 150 2 left leave VBN cord-023134-y665agnh 150 3 ventricular ventricular JJ cord-023134-y665agnh 150 4 outflow outflow JJ cord-023134-y665agnh 150 5 tract tract JJ cord-023134-y665agnh 150 6 obstruction obstruction NN cord-023134-y665agnh 150 7 ( ( -LRB- cord-023134-y665agnh 150 8 DLVOTO DLVOTO NNP cord-023134-y665agnh 150 9 ) ) -RRB- cord-023134-y665agnh 150 10 is be VBZ cord-023134-y665agnh 150 11 a a DT cord-023134-y665agnh 150 12 common common JJ cord-023134-y665agnh 150 13 cause cause NN cord-023134-y665agnh 150 14 of of IN cord-023134-y665agnh 150 15 heart heart NN cord-023134-y665agnh 150 16 murmurs murmur NNS cord-023134-y665agnh 150 17 in in IN cord-023134-y665agnh 150 18 adult adult NN cord-023134-y665agnh 150 19 cats cat NNS cord-023134-y665agnh 150 20 . . . cord-023134-y665agnh 151 1 The the DT cord-023134-y665agnh 151 2 obstruction obstruction NN cord-023134-y665agnh 151 3 is be VBZ cord-023134-y665agnh 151 4 caused cause VBN cord-023134-y665agnh 151 5 by by IN cord-023134-y665agnh 151 6 Systolic Systolic NNP cord-023134-y665agnh 151 7 Anterior Anterior NNP cord-023134-y665agnh 151 8 Motion Motion NNP cord-023134-y665agnh 151 9 ( ( -LRB- cord-023134-y665agnh 151 10 SAM SAM NNP cord-023134-y665agnh 151 11 ) ) -RRB- cord-023134-y665agnh 151 12 of of IN cord-023134-y665agnh 151 13 the the DT cord-023134-y665agnh 151 14 mitral mitral JJ cord-023134-y665agnh 151 15 valve valve NN cord-023134-y665agnh 151 16 . . . cord-023134-y665agnh 152 1 SAM SAM NNP cord-023134-y665agnh 152 2 is be VBZ cord-023134-y665agnh 152 3 typically typically RB cord-023134-y665agnh 152 4 observed observe VBN cord-023134-y665agnh 152 5 in in IN cord-023134-y665agnh 152 6 adult adult NN cord-023134-y665agnh 152 7 cats cat NNS cord-023134-y665agnh 152 8 and and CC cord-023134-y665agnh 152 9 humans human NNS cord-023134-y665agnh 152 10 with with IN cord-023134-y665agnh 152 11 hypertrophic hypertrophic JJ cord-023134-y665agnh 152 12 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 152 13 ( ( -LRB- cord-023134-y665agnh 152 14 HCM HCM NNP cord-023134-y665agnh 152 15 ) ) -RRB- cord-023134-y665agnh 152 16 . . . cord-023134-y665agnh 153 1 Many many JJ cord-023134-y665agnh 153 2 studies study NNS cord-023134-y665agnh 153 3 support support VBP cord-023134-y665agnh 153 4 the the DT cord-023134-y665agnh 153 5 concept concept NN cord-023134-y665agnh 153 6 that that IN cord-023134-y665agnh 153 7 structural structural JJ cord-023134-y665agnh 153 8 deformities deformity NNS cord-023134-y665agnh 153 9 of of IN cord-023134-y665agnh 153 10 the the DT cord-023134-y665agnh 153 11 mitral mitral JJ cord-023134-y665agnh 153 12 valves valve NNS cord-023134-y665agnh 153 13 and and CC cord-023134-y665agnh 153 14 the the DT cord-023134-y665agnh 153 15 papillary papillary JJ cord-023134-y665agnh 153 16 muscles muscle NNS cord-023134-y665agnh 153 17 could could MD cord-023134-y665agnh 153 18 be be VB cord-023134-y665agnh 153 19 primary primary JJ cord-023134-y665agnh 153 20 causes cause NNS cord-023134-y665agnh 153 21 of of IN cord-023134-y665agnh 153 22 SAM SAM NNP cord-023134-y665agnh 153 23 . . . cord-023134-y665agnh 154 1 Congenital congenital JJ cord-023134-y665agnh 154 2 malformations malformation NNS cord-023134-y665agnh 154 3 of of IN cord-023134-y665agnh 154 4 the the DT cord-023134-y665agnh 154 5 mitral mitral JJ cord-023134-y665agnh 154 6 valve valve NN cord-023134-y665agnh 154 7 causing cause VBG cord-023134-y665agnh 154 8 SAM SAM NNP cord-023134-y665agnh 154 9 and and CC cord-023134-y665agnh 154 10 DLVOTO DLVOTO NNP cord-023134-y665agnh 154 11 have have VBP cord-023134-y665agnh 154 12 been be VBN cord-023134-y665agnh 154 13 observed observe VBN cord-023134-y665agnh 154 14 in in IN cord-023134-y665agnh 154 15 dogs dog NNS cord-023134-y665agnh 154 16 and and CC cord-023134-y665agnh 154 17 people people NNS cord-023134-y665agnh 154 18 and and CC cord-023134-y665agnh 154 19 are be VBP cord-023134-y665agnh 154 20 believed believe VBN cord-023134-y665agnh 154 21 to to TO cord-023134-y665agnh 154 22 exist exist VB cord-023134-y665agnh 154 23 in in IN cord-023134-y665agnh 154 24 cats cat NNS cord-023134-y665agnh 154 25 , , , cord-023134-y665agnh 154 26 but but CC cord-023134-y665agnh 154 27 have have VBP cord-023134-y665agnh 154 28 not not RB cord-023134-y665agnh 154 29 yet yet RB cord-023134-y665agnh 154 30 been be VBN cord-023134-y665agnh 154 31 reported report VBN cord-023134-y665agnh 154 32 . . . cord-023134-y665agnh 155 1 The the DT cord-023134-y665agnh 155 2 aim aim NN cord-023134-y665agnh 155 3 of of IN cord-023134-y665agnh 155 4 this this DT cord-023134-y665agnh 155 5 study study NN cord-023134-y665agnh 155 6 was be VBD cord-023134-y665agnh 155 7 to to TO cord-023134-y665agnh 155 8 report report VB cord-023134-y665agnh 155 9 the the DT cord-023134-y665agnh 155 10 clinical clinical JJ cord-023134-y665agnh 155 11 and and CC cord-023134-y665agnh 155 12 echocardiographic echocardiographic JJ cord-023134-y665agnh 155 13 findings finding NNS cord-023134-y665agnh 155 14 in in IN cord-023134-y665agnh 155 15 young young JJ cord-023134-y665agnh 155 16 cats cat NNS cord-023134-y665agnh 155 17 with with IN cord-023134-y665agnh 155 18 DLV DLV NNP cord-023134-y665agnh 155 19 - - HYPH cord-023134-y665agnh 155 20 OTO.Thirteen OTO.Thirteen NNP cord-023134-y665agnh 155 21 domestic domestic JJ cord-023134-y665agnh 155 22 shorthair shorthair JJ cord-023134-y665agnh 155 23 kittens kitten NNS cord-023134-y665agnh 155 24 , , , cord-023134-y665agnh 155 25 between between IN cord-023134-y665agnh 155 26 12 12 CD cord-023134-y665agnh 155 27 - - SYM cord-023134-y665agnh 155 28 21 21 CD cord-023134-y665agnh 155 29 weeks week NNS cord-023134-y665agnh 155 30 of of IN cord-023134-y665agnh 155 31 age age NN cord-023134-y665agnh 155 32 , , , cord-023134-y665agnh 155 33 presented present VBN cord-023134-y665agnh 155 34 with with IN cord-023134-y665agnh 155 35 a a DT cord-023134-y665agnh 155 36 systolic systolic JJ cord-023134-y665agnh 155 37 heart heart NN cord-023134-y665agnh 155 38 murmur murmur NN cord-023134-y665agnh 155 39 between between IN cord-023134-y665agnh 155 40 May May NNP cord-023134-y665agnh 155 41 1 1 CD cord-023134-y665agnh 155 42 st st NNP cord-023134-y665agnh 155 43 2009 2009 CD cord-023134-y665agnh 155 44 until until IN cord-023134-y665agnh 155 45 March March NNP cord-023134-y665agnh 155 46 31 31 CD cord-023134-y665agnh 155 47 st st NNP cord-023134-y665agnh 155 48 2012 2012 CD cord-023134-y665agnh 155 49 . . . cord-023134-y665agnh 156 1 All all DT cord-023134-y665agnh 156 2 cats cat NNS cord-023134-y665agnh 156 3 underwent undergo VBD cord-023134-y665agnh 156 4 a a DT cord-023134-y665agnh 156 5 physical physical JJ cord-023134-y665agnh 156 6 examination examination NN cord-023134-y665agnh 156 7 preceding precede VBG cord-023134-y665agnh 156 8 2D- 2d- CD cord-023134-y665agnh 156 9 , , , cord-023134-y665agnh 156 10 M m NN cord-023134-y665agnh 156 11 - - HYPH cord-023134-y665agnh 156 12 mode mode NN cord-023134-y665agnh 156 13 and and CC cord-023134-y665agnh 156 14 Doppler doppler NN cord-023134-y665agnh 156 15 echocardiography echocardiography NN cord-023134-y665agnh 156 16 . . . cord-023134-y665agnh 157 1 Kittens kitten NNS cord-023134-y665agnh 157 2 were be VBD cord-023134-y665agnh 157 3 from from IN cord-023134-y665agnh 157 4 adoption adoption NN cord-023134-y665agnh 157 5 programs program NNS cord-023134-y665agnh 157 6 run run VBN cord-023134-y665agnh 157 7 by by IN cord-023134-y665agnh 157 8 either either CC cord-023134-y665agnh 157 9 Dierenasiel Dierenasiel NNP cord-023134-y665agnh 157 10 Breda Breda NNP cord-023134-y665agnh 157 11 e.o e.o NNP cord-023134-y665agnh 157 12 . . . cord-023134-y665agnh 158 1 ( ( -LRB- cord-023134-y665agnh 158 2 n=8/2090 n=8/2090 NNP cord-023134-y665agnh 158 3 ) ) -RRB- cord-023134-y665agnh 158 4 or or CC cord-023134-y665agnh 158 5 by by IN cord-023134-y665agnh 158 6 Dierenopvangcentrum Dierenopvangcentrum NNP cord-023134-y665agnh 158 7 Tilburg Tilburg NNP cord-023134-y665agnh 158 8 e.o e.o NNP cord-023134-y665agnh 158 9 . . . cord-023134-y665agnh 158 10 ( ( -LRB- cord-023134-y665agnh 158 11 n=5/845 n=5/845 CD cord-023134-y665agnh 158 12 ) ) -RRB- cord-023134-y665agnh 159 1 Nine nine CD cord-023134-y665agnh 159 2 kittens kitten NNS cord-023134-y665agnh 159 3 were be VBD cord-023134-y665agnh 159 4 male male JJ cord-023134-y665agnh 159 5 , , , cord-023134-y665agnh 159 6 four four CD cord-023134-y665agnh 159 7 were be VBD cord-023134-y665agnh 159 8 female female JJ cord-023134-y665agnh 159 9 . . . cord-023134-y665agnh 160 1 All all DT cord-023134-y665agnh 160 2 kittens kitten NNS cord-023134-y665agnh 160 3 were be VBD cord-023134-y665agnh 160 4 asymptomatic asymptomatic JJ cord-023134-y665agnh 160 5 . . . cord-023134-y665agnh 161 1 DLVOTO DLVOTO NNP cord-023134-y665agnh 161 2 caused cause VBN cord-023134-y665agnh 161 3 by by IN cord-023134-y665agnh 161 4 SAM SAM NNP cord-023134-y665agnh 161 5 was be VBD cord-023134-y665agnh 161 6 present present JJ cord-023134-y665agnh 161 7 in in IN cord-023134-y665agnh 161 8 all all DT cord-023134-y665agnh 161 9 animals animal NNS cord-023134-y665agnh 161 10 , , , cord-023134-y665agnh 161 11 uninterruptedly uninterruptedly RB cord-023134-y665agnh 161 12 in in IN cord-023134-y665agnh 161 13 eleven eleven CD cord-023134-y665agnh 161 14 , , , cord-023134-y665agnh 161 15 only only RB cord-023134-y665agnh 161 16 at at IN cord-023134-y665agnh 161 17 high high JJ cord-023134-y665agnh 161 18 heart heart NN cord-023134-y665agnh 161 19 rates rate NNS cord-023134-y665agnh 161 20 in in IN cord-023134-y665agnh 161 21 two two CD cord-023134-y665agnh 161 22 . . . cord-023134-y665agnh 162 1 Seven seven CD cord-023134-y665agnh 162 2 cats cat NNS cord-023134-y665agnh 162 3 had have VBD cord-023134-y665agnh 162 4 normal normal JJ cord-023134-y665agnh 162 5 left leave VBN cord-023134-y665agnh 162 6 ventricular ventricular JJ cord-023134-y665agnh 162 7 dimensions dimension NNS cord-023134-y665agnh 162 8 ( ( -LRB- cord-023134-y665agnh 162 9 nLVD nLVD NNS cord-023134-y665agnh 162 10 ) ) -RRB- cord-023134-y665agnh 162 11 , , , cord-023134-y665agnh 162 12 six six CD cord-023134-y665agnh 162 13 cats cat NNS cord-023134-y665agnh 162 14 had have VBD cord-023134-y665agnh 162 15 concentric concentric JJ cord-023134-y665agnh 162 16 left leave VBN cord-023134-y665agnh 162 17 ventricular ventricular JJ cord-023134-y665agnh 162 18 hypertrophy hypertrophy NN cord-023134-y665agnh 162 19 ( ( -LRB- cord-023134-y665agnh 162 20 cLVH clvh NN cord-023134-y665agnh 162 21 ) ) -RRB- cord-023134-y665agnh 162 22 . . . cord-023134-y665agnh 163 1 In in IN cord-023134-y665agnh 163 2 five five CD cord-023134-y665agnh 163 3 cats cat NNS cord-023134-y665agnh 163 4 papillary papillary JJ cord-023134-y665agnh 163 5 muscle muscle NN cord-023134-y665agnh 163 6 abnormalities abnormality NNS cord-023134-y665agnh 163 7 were be VBD cord-023134-y665agnh 163 8 noted note VBN cord-023134-y665agnh 163 9 being be VBG cord-023134-y665agnh 163 10 an an DT cord-023134-y665agnh 163 11 accessory accessory JJ cord-023134-y665agnh 163 12 papillary papillary JJ cord-023134-y665agnh 163 13 muscle muscle NN cord-023134-y665agnh 163 14 in in IN cord-023134-y665agnh 163 15 two two CD cord-023134-y665agnh 163 16 and and CC cord-023134-y665agnh 163 17 enlarged enlarged JJ cord-023134-y665agnh 163 18 papillary papillary JJ cord-023134-y665agnh 163 19 muscles muscle NNS cord-023134-y665agnh 163 20 in in IN cord-023134-y665agnh 163 21 three three CD cord-023134-y665agnh 163 22 , , , cord-023134-y665agnh 163 23 two two CD cord-023134-y665agnh 163 24 of of IN cord-023134-y665agnh 163 25 which which WDT cord-023134-y665agnh 163 26 had have VBD cord-023134-y665agnh 163 27 cLVH.Twelve clvh.twelve NN cord-023134-y665agnh 163 28 animals animal NNS cord-023134-y665agnh 163 29 were be VBD cord-023134-y665agnh 163 30 reexamined reexamine VBN cord-023134-y665agnh 163 31 2 2 CD cord-023134-y665agnh 163 32 - - SYM cord-023134-y665agnh 163 33 5 5 CD cord-023134-y665agnh 163 34 months month NNS cord-023134-y665agnh 163 35 after after IN cord-023134-y665agnh 163 36 the the DT cord-023134-y665agnh 163 37 initial initial JJ cord-023134-y665agnh 163 38 examination examination NN cord-023134-y665agnh 163 39 . . . cord-023134-y665agnh 164 1 All all DT cord-023134-y665agnh 164 2 animals animal NNS cord-023134-y665agnh 164 3 were be VBD cord-023134-y665agnh 164 4 still still RB cord-023134-y665agnh 164 5 asymptomatic asymptomatic JJ cord-023134-y665agnh 164 6 . . . cord-023134-y665agnh 165 1 A a DT cord-023134-y665agnh 165 2 heart heart NN cord-023134-y665agnh 165 3 murmur murmur NN cord-023134-y665agnh 165 4 and and CC cord-023134-y665agnh 165 5 DLVOTO DLVOTO NNP cord-023134-y665agnh 165 6 could could MD cord-023134-y665agnh 165 7 no no RB cord-023134-y665agnh 165 8 longer longer RB cord-023134-y665agnh 165 9 be be VB cord-023134-y665agnh 165 10 detected detect VBN cord-023134-y665agnh 165 11 in in IN cord-023134-y665agnh 165 12 nine nine CD cord-023134-y665agnh 165 13 animals animal NNS cord-023134-y665agnh 165 14 , , , cord-023134-y665agnh 165 15 five five CD cord-023134-y665agnh 165 16 with with IN cord-023134-y665agnh 165 17 initial initial JJ cord-023134-y665agnh 165 18 cLVH clvh NN cord-023134-y665agnh 165 19 and and CC cord-023134-y665agnh 165 20 four four CD cord-023134-y665agnh 165 21 with with IN cord-023134-y665agnh 165 22 initial initial JJ cord-023134-y665agnh 165 23 nLVD nLVD NNS cord-023134-y665agnh 165 24 . . . cord-023134-y665agnh 166 1 In in IN cord-023134-y665agnh 166 2 three three CD cord-023134-y665agnh 166 3 animals animal NNS cord-023134-y665agnh 166 4 a a DT cord-023134-y665agnh 166 5 heart heart NN cord-023134-y665agnh 166 6 murmur murmur NN cord-023134-y665agnh 166 7 and and CC cord-023134-y665agnh 166 8 DLVOTO DLVOTO NNP cord-023134-y665agnh 166 9 were be VBD cord-023134-y665agnh 166 10 still still RB cord-023134-y665agnh 166 11 present present JJ cord-023134-y665agnh 166 12 . . . cord-023134-y665agnh 167 1 Two two CD cord-023134-y665agnh 167 2 of of IN cord-023134-y665agnh 167 3 the the DT cord-023134-y665agnh 167 4 cats cat NNS cord-023134-y665agnh 167 5 with with IN cord-023134-y665agnh 167 6 nLVD nLVD NNS cord-023134-y665agnh 167 7 developed developed JJ cord-023134-y665agnh 167 8 cLVH clvh NN cord-023134-y665agnh 167 9 . . . cord-023134-y665agnh 168 1 One one CD cord-023134-y665agnh 168 2 cat cat NN cord-023134-y665agnh 168 3 with with IN cord-023134-y665agnh 168 4 initial initial JJ cord-023134-y665agnh 168 5 cLVH clvh NN cord-023134-y665agnh 168 6 continued continue VBD cord-023134-y665agnh 168 7 to to TO cord-023134-y665agnh 168 8 have have VB cord-023134-y665agnh 168 9 cLVH.Treatment clvh.treatment CD cord-023134-y665agnh 168 10 with with IN cord-023134-y665agnh 168 11 atenolol atenolol NN cord-023134-y665agnh 168 12 was be VBD cord-023134-y665agnh 168 13 instigated instigate VBN cord-023134-y665agnh 168 14 in in IN cord-023134-y665agnh 168 15 three three CD cord-023134-y665agnh 168 16 cats cat NNS cord-023134-y665agnh 168 17 which which WDT cord-023134-y665agnh 168 18 continued continue VBD cord-023134-y665agnh 168 19 to to TO cord-023134-y665agnh 168 20 have have VB cord-023134-y665agnh 168 21 DLVOTO DLVOTO NNP cord-023134-y665agnh 168 22 and and CC cord-023134-y665agnh 168 23 cLVH clvh NN cord-023134-y665agnh 168 24 . . . cord-023134-y665agnh 169 1 Two two CD cord-023134-y665agnh 169 2 cats cat NNS cord-023134-y665agnh 169 3 were be VBD cord-023134-y665agnh 169 4 reexamined reexamine VBN cord-023134-y665agnh 169 5 . . . cord-023134-y665agnh 170 1 Treatment treatment NN cord-023134-y665agnh 170 2 with with IN cord-023134-y665agnh 170 3 atenolol atenolol NN cord-023134-y665agnh 170 4 led lead VBD cord-023134-y665agnh 170 5 to to TO cord-023134-y665agnh 170 6 complete complete JJ cord-023134-y665agnh 170 7 reversal reversal NN cord-023134-y665agnh 170 8 of of IN cord-023134-y665agnh 170 9 cLVH clvh NN cord-023134-y665agnh 170 10 in in IN cord-023134-y665agnh 170 11 both both DT cord-023134-y665agnh 170 12 cases case NNS cord-023134-y665agnh 170 13 . . . cord-023134-y665agnh 171 1 Interventional interventional JJ cord-023134-y665agnh 171 2 radiology radiology NN cord-023134-y665agnh 171 3 techniques technique NNS cord-023134-y665agnh 171 4 have have VBP cord-023134-y665agnh 171 5 been be VBN cord-023134-y665agnh 171 6 used use VBN cord-023134-y665agnh 171 7 to to TO cord-023134-y665agnh 171 8 palliate palliate VB cord-023134-y665agnh 171 9 both both CC cord-023134-y665agnh 171 10 malignant malignant JJ cord-023134-y665agnh 171 11 and and CC cord-023134-y665agnh 171 12 non non JJ cord-023134-y665agnh 171 13 - - JJ cord-023134-y665agnh 171 14 malignant malignant JJ cord-023134-y665agnh 171 15 causes cause NNS cord-023134-y665agnh 171 16 of of IN cord-023134-y665agnh 171 17 vascular vascular JJ cord-023134-y665agnh 171 18 obstruction obstruction NN cord-023134-y665agnh 171 19 for for IN cord-023134-y665agnh 171 20 both both CC cord-023134-y665agnh 171 21 intrinsic intrinsic JJ cord-023134-y665agnh 171 22 and and CC cord-023134-y665agnh 171 23 extrinsic extrinsic JJ cord-023134-y665agnh 171 24 lesions lesion NNS cord-023134-y665agnh 171 25 . . . cord-023134-y665agnh 172 1 Three three CD cord-023134-y665agnh 172 2 dogs dog NNS cord-023134-y665agnh 172 3 presented present VBN cord-023134-y665agnh 172 4 for for IN cord-023134-y665agnh 172 5 with with IN cord-023134-y665agnh 172 6 large large JJ cord-023134-y665agnh 172 7 , , , cord-023134-y665agnh 172 8 non non JJ cord-023134-y665agnh 172 9 - - JJ cord-023134-y665agnh 172 10 resectable resectable JJ cord-023134-y665agnh 172 11 cardiac cardiac JJ cord-023134-y665agnh 172 12 masses masse NNS cord-023134-y665agnh 172 13 obstructing obstruct VBG cord-023134-y665agnh 172 14 venous venous JJ cord-023134-y665agnh 172 15 return return NN cord-023134-y665agnh 172 16 to to IN cord-023134-y665agnh 172 17 the the DT cord-023134-y665agnh 172 18 right right JJ cord-023134-y665agnh 172 19 atrium atrium NN cord-023134-y665agnh 172 20 . . . cord-023134-y665agnh 173 1 Venous venous JJ cord-023134-y665agnh 173 2 return return NN cord-023134-y665agnh 173 3 to to IN cord-023134-y665agnh 173 4 the the DT cord-023134-y665agnh 173 5 heart heart NN cord-023134-y665agnh 173 6 was be VBD cord-023134-y665agnh 173 7 severely severely RB cord-023134-y665agnh 173 8 obstructed obstruct VBN cord-023134-y665agnh 173 9 leading lead VBG cord-023134-y665agnh 173 10 to to IN cord-023134-y665agnh 173 11 congestion congestion NN cord-023134-y665agnh 173 12 with with IN cord-023134-y665agnh 173 13 subsequent subsequent JJ cord-023134-y665agnh 173 14 ascites ascite NNS cord-023134-y665agnh 173 15 ( ( -LRB- cord-023134-y665agnh 173 16 2 2 CD cord-023134-y665agnh 173 17 ) ) -RRB- cord-023134-y665agnh 173 18 or or CC cord-023134-y665agnh 173 19 head head VB cord-023134-y665agnh 173 20 swelling swell VBG cord-023134-y665agnh 173 21 and and CC cord-023134-y665agnh 173 22 pleural pleural JJ cord-023134-y665agnh 173 23 effusion effusion NN cord-023134-y665agnh 173 24 ( ( -LRB- cord-023134-y665agnh 173 25 1 1 CD cord-023134-y665agnh 173 26 ) ) -RRB- cord-023134-y665agnh 173 27 . . . cord-023134-y665agnh 174 1 Due due IN cord-023134-y665agnh 174 2 to to IN cord-023134-y665agnh 174 3 the the DT cord-023134-y665agnh 174 4 extensive extensive JJ cord-023134-y665agnh 174 5 nature nature NN cord-023134-y665agnh 174 6 of of IN cord-023134-y665agnh 174 7 the the DT cord-023134-y665agnh 174 8 disease disease NN cord-023134-y665agnh 174 9 , , , cord-023134-y665agnh 174 10 an an DT cord-023134-y665agnh 174 11 interventional interventional JJ cord-023134-y665agnh 174 12 palliative palliative JJ cord-023134-y665agnh 174 13 approach approach NN cord-023134-y665agnh 174 14 was be VBD cord-023134-y665agnh 174 15 pursued pursue VBN cord-023134-y665agnh 174 16 . . . cord-023134-y665agnh 175 1 Transatrial transatrial JJ cord-023134-y665agnh 175 2 self self NN cord-023134-y665agnh 175 3 - - HYPH cord-023134-y665agnh 175 4 expanding expand VBG cord-023134-y665agnh 175 5 metallic metallic JJ cord-023134-y665agnh 175 6 nitinol nitinol JJ cord-023134-y665agnh 175 7 stents stent NNS cord-023134-y665agnh 175 8 were be VBD cord-023134-y665agnh 175 9 placed place VBN cord-023134-y665agnh 175 10 from from IN cord-023134-y665agnh 175 11 the the DT cord-023134-y665agnh 175 12 CdVC CdVC NNP cord-023134-y665agnh 175 13 to to IN cord-023134-y665agnh 175 14 the the DT cord-023134-y665agnh 175 15 CrVC CrVC NNP cord-023134-y665agnh 175 16 in in IN cord-023134-y665agnh 175 17 order order NN cord-023134-y665agnh 175 18 to to TO cord-023134-y665agnh 175 19 restore restore VB cord-023134-y665agnh 175 20 venous venous JJ cord-023134-y665agnh 175 21 return return NN cord-023134-y665agnh 175 22 to to IN cord-023134-y665agnh 175 23 the the DT cord-023134-y665agnh 175 24 heart heart NN cord-023134-y665agnh 175 25 via via IN cord-023134-y665agnh 175 26 blood blood NN cord-023134-y665agnh 175 27 flow flow NN cord-023134-y665agnh 175 28 through through IN cord-023134-y665agnh 175 29 the the DT cord-023134-y665agnh 175 30 stent stent NN cord-023134-y665agnh 175 31 interstices interstice NNS cord-023134-y665agnh 175 32 . . . cord-023134-y665agnh 176 1 In in IN cord-023134-y665agnh 176 2 all all DT cord-023134-y665agnh 176 3 cases case NNS cord-023134-y665agnh 176 4 , , , cord-023134-y665agnh 176 5 stent stent NN cord-023134-y665agnh 176 6 placement placement NN cord-023134-y665agnh 176 7 was be VBD cord-023134-y665agnh 176 8 successful successful JJ cord-023134-y665agnh 176 9 and and CC cord-023134-y665agnh 176 10 resolution resolution NN cord-023134-y665agnh 176 11 of of IN cord-023134-y665agnh 176 12 clinical clinical JJ cord-023134-y665agnh 176 13 signs sign NNS cord-023134-y665agnh 176 14 achieved achieve VBN cord-023134-y665agnh 176 15 . . . cord-023134-y665agnh 177 1 Two two CD cord-023134-y665agnh 177 2 dogs dog NNS cord-023134-y665agnh 177 3 required require VBD cord-023134-y665agnh 177 4 additional additional JJ cord-023134-y665agnh 177 5 stent stent JJ cord-023134-y665agnh 177 6 placement placement NN cord-023134-y665agnh 177 7 in in IN cord-023134-y665agnh 177 8 14 14 CD cord-023134-y665agnh 177 9 months month NNS cord-023134-y665agnh 177 10 and and CC cord-023134-y665agnh 177 11 6 6 CD cord-023134-y665agnh 177 12 months month NNS cord-023134-y665agnh 177 13 , , , cord-023134-y665agnh 177 14 respectively respectively RB cord-023134-y665agnh 177 15 , , , cord-023134-y665agnh 177 16 for for IN cord-023134-y665agnh 177 17 stent stent JJ cord-023134-y665agnh 177 18 occlusion occlusion NN cord-023134-y665agnh 177 19 . . . cord-023134-y665agnh 178 1 In in IN cord-023134-y665agnh 178 2 both both DT cord-023134-y665agnh 178 3 cases case NNS cord-023134-y665agnh 178 4 , , , cord-023134-y665agnh 178 5 restenting restenting NN cord-023134-y665agnh 178 6 resulted result VBD cord-023134-y665agnh 178 7 in in IN cord-023134-y665agnh 178 8 ascites ascites NN cord-023134-y665agnh 178 9 resolution resolution NN cord-023134-y665agnh 178 10 or or CC cord-023134-y665agnh 178 11 substantial substantial JJ cord-023134-y665agnh 178 12 reduction reduction NN cord-023134-y665agnh 178 13 . . . cord-023134-y665agnh 179 1 One one CD cord-023134-y665agnh 179 2 dog dog NN cord-023134-y665agnh 179 3 was be VBD cord-023134-y665agnh 179 4 euthanized euthanize VBN cord-023134-y665agnh 179 5 21 21 CD cord-023134-y665agnh 179 6 months month NNS cord-023134-y665agnh 179 7 following follow VBG cord-023134-y665agnh 179 8 initial initial JJ cord-023134-y665agnh 179 9 stent stent NN cord-023134-y665agnh 179 10 placement placement NN cord-023134-y665agnh 179 11 for for IN cord-023134-y665agnh 179 12 general general JJ cord-023134-y665agnh 179 13 systemic systemic JJ cord-023134-y665agnh 179 14 decline decline NN cord-023134-y665agnh 179 15 and and CC cord-023134-y665agnh 179 16 return return NN cord-023134-y665agnh 179 17 of of IN cord-023134-y665agnh 179 18 moderate moderate JJ cord-023134-y665agnh 179 19 ascites ascite NNS cord-023134-y665agnh 179 20 . . . cord-023134-y665agnh 180 1 The the DT cord-023134-y665agnh 180 2 second second JJ cord-023134-y665agnh 180 3 dog dog NN cord-023134-y665agnh 180 4 remains remain VBZ cord-023134-y665agnh 180 5 alive alive JJ cord-023134-y665agnh 180 6 22 22 CD cord-023134-y665agnh 180 7 months month NNS cord-023134-y665agnh 180 8 following follow VBG cord-023134-y665agnh 180 9 initial initial JJ cord-023134-y665agnh 180 10 stent stent NN cord-023134-y665agnh 180 11 placement placement NN cord-023134-y665agnh 180 12 on on IN cord-023134-y665agnh 180 13 diuretic diuretic JJ cord-023134-y665agnh 180 14 therapy therapy NN cord-023134-y665agnh 180 15 with with IN cord-023134-y665agnh 180 16 moderate moderate JJ cord-023134-y665agnh 180 17 ascites ascites NN cord-023134-y665agnh 180 18 present present JJ cord-023134-y665agnh 180 19 . . . cord-023134-y665agnh 181 1 The the DT cord-023134-y665agnh 181 2 third third JJ cord-023134-y665agnh 181 3 died die VBD cord-023134-y665agnh 181 4 of of IN cord-023134-y665agnh 181 5 undetermined undetermined JJ cord-023134-y665agnh 181 6 causes cause NNS cord-023134-y665agnh 181 7 5 5 CD cord-023134-y665agnh 181 8 1/2 1/2 CD cord-023134-y665agnh 181 9 months month NNS cord-023134-y665agnh 181 10 later later RB cord-023134-y665agnh 181 11 . . . cord-023134-y665agnh 182 1 To to IN cord-023134-y665agnh 182 2 the the DT cord-023134-y665agnh 182 3 authors author NNS cord-023134-y665agnh 182 4 ' ' POS cord-023134-y665agnh 182 5 knowledge knowledge NN cord-023134-y665agnh 182 6 , , , cord-023134-y665agnh 182 7 this this DT cord-023134-y665agnh 182 8 is be VBZ cord-023134-y665agnh 182 9 the the DT cord-023134-y665agnh 182 10 first first JJ cord-023134-y665agnh 182 11 report report NN cord-023134-y665agnh 182 12 of of IN cord-023134-y665agnh 182 13 longterm longterm JJ cord-023134-y665agnh 182 14 palliative palliative NN cord-023134-y665agnh 182 15 transatrial transatrial NN cord-023134-y665agnh 182 16 stenting stenting NN cord-023134-y665agnh 182 17 for for IN cord-023134-y665agnh 182 18 cardiac cardiac JJ cord-023134-y665agnh 182 19 tumors tumor NNS cord-023134-y665agnh 182 20 affecting affect VBG cord-023134-y665agnh 182 21 venous venous JJ cord-023134-y665agnh 182 22 return return NN cord-023134-y665agnh 182 23 to to IN cord-023134-y665agnh 182 24 the the DT cord-023134-y665agnh 182 25 heart heart NN cord-023134-y665agnh 182 26 . . . cord-023134-y665agnh 183 1 The the DT cord-023134-y665agnh 183 2 stents stent NNS cord-023134-y665agnh 183 3 were be VBD cord-023134-y665agnh 183 4 well well RB cord-023134-y665agnh 183 5 tolerated tolerate VBN cord-023134-y665agnh 183 6 in in IN cord-023134-y665agnh 183 7 these these DT cord-023134-y665agnh 183 8 canine canine JJ cord-023134-y665agnh 183 9 patients patient NNS cord-023134-y665agnh 183 10 for for IN cord-023134-y665agnh 183 11 which which WDT cord-023134-y665agnh 183 12 surgical surgical JJ cord-023134-y665agnh 183 13 options option NNS cord-023134-y665agnh 183 14 were be VBD cord-023134-y665agnh 183 15 not not RB cord-023134-y665agnh 183 16 possible possible JJ cord-023134-y665agnh 183 17 . . . cord-023134-y665agnh 184 1 The the DT cord-023134-y665agnh 184 2 Irish irish JJ cord-023134-y665agnh 184 3 wolfhound wolfhound NN cord-023134-y665agnh 184 4 ( ( -LRB- cord-023134-y665agnh 184 5 IW IW NNP cord-023134-y665agnh 184 6 ) ) -RRB- cord-023134-y665agnh 184 7 dog dog NN cord-023134-y665agnh 184 8 has have VBZ cord-023134-y665agnh 184 9 a a DT cord-023134-y665agnh 184 10 high high JJ cord-023134-y665agnh 184 11 prevalence prevalence NN cord-023134-y665agnh 184 12 of of IN cord-023134-y665agnh 184 13 heart heart NN cord-023134-y665agnh 184 14 diseases disease NNS cord-023134-y665agnh 184 15 , , , cord-023134-y665agnh 184 16 particularly particularly RB cord-023134-y665agnh 184 17 dilated dilated JJ cord-023134-y665agnh 184 18 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 184 19 ( ( -LRB- cord-023134-y665agnh 184 20 DCM DCM NNP cord-023134-y665agnh 184 21 ) ) -RRB- cord-023134-y665agnh 184 22 and and CC cord-023134-y665agnh 184 23 atrial atrial JJ cord-023134-y665agnh 184 24 fibrillation fibrillation NN cord-023134-y665agnh 184 25 ( ( -LRB- cord-023134-y665agnh 184 26 AF).During af).dure VBG cord-023134-y665agnh 184 27 a a DT cord-023134-y665agnh 184 28 prospective prospective JJ cord-023134-y665agnh 184 29 longitudinal longitudinal JJ cord-023134-y665agnh 184 30 study study NN cord-023134-y665agnh 184 31 , , , cord-023134-y665agnh 184 32 1438 1438 CD cord-023134-y665agnh 184 33 Irish irish JJ cord-023134-y665agnh 184 34 wolfhounds wolfhound NNS cord-023134-y665agnh 184 35 were be VBD cord-023134-y665agnh 184 36 investigated investigate VBN cord-023134-y665agnh 184 37 by by IN cord-023134-y665agnh 184 38 one one CD cord-023134-y665agnh 184 39 veterinary veterinary JJ cord-023134-y665agnh 184 40 cardiologist cardiologist NN cord-023134-y665agnh 184 41 ( ( -LRB- cord-023134-y665agnh 184 42 2 2 CD cord-023134-y665agnh 184 43 ) ) -RRB- cord-023134-y665agnh 184 44 between between IN cord-023134-y665agnh 184 45 1990 1990 CD cord-023134-y665agnh 184 46 and and CC cord-023134-y665agnh 184 47 2012 2012 CD cord-023134-y665agnh 184 48 . . . cord-023134-y665agnh 185 1 DCM DCM NNP cord-023134-y665agnh 185 2 was be VBD cord-023134-y665agnh 185 3 diagnosed diagnose VBN cord-023134-y665agnh 185 4 in in IN cord-023134-y665agnh 185 5 about about RB cord-023134-y665agnh 185 6 26 26 CD cord-023134-y665agnh 185 7 % % NN cord-023134-y665agnh 185 8 of of IN cord-023134-y665agnh 185 9 dogs dog NNS cord-023134-y665agnh 185 10 . . . cord-023134-y665agnh 186 1 In in IN cord-023134-y665agnh 186 2 88 88 CD cord-023134-y665agnh 186 3 % % NN cord-023134-y665agnh 186 4 of of IN cord-023134-y665agnh 186 5 cases case NNS cord-023134-y665agnh 186 6 , , , cord-023134-y665agnh 186 7 DCM DCM NNP cord-023134-y665agnh 186 8 was be VBD cord-023134-y665agnh 186 9 accompanied accompany VBN cord-023134-y665agnh 186 10 by by IN cord-023134-y665agnh 186 11 AF AF NNP cord-023134-y665agnh 186 12 . . . cord-023134-y665agnh 187 1 AF AF NNP cord-023134-y665agnh 187 2 without without IN cord-023134-y665agnh 187 3 evidence evidence NN cord-023134-y665agnh 187 4 of of IN cord-023134-y665agnh 187 5 DCM DCM NNP cord-023134-y665agnh 187 6 was be VBD cord-023134-y665agnh 187 7 diagnosed diagnose VBN cord-023134-y665agnh 187 8 in in IN cord-023134-y665agnh 187 9 31 31 CD cord-023134-y665agnh 187 10 dogs dog NNS cord-023134-y665agnh 187 11 ( ( -LRB- cord-023134-y665agnh 187 12 2%).For 2%).for CD cord-023134-y665agnh 187 13 pathological pathological JJ cord-023134-y665agnh 187 14 investigations investigation NNS cord-023134-y665agnh 187 15 , , , cord-023134-y665agnh 187 16 hearts heart NNS cord-023134-y665agnh 187 17 of of IN cord-023134-y665agnh 187 18 19 19 CD cord-023134-y665agnh 187 19 IWs iw NNS cord-023134-y665agnh 187 20 were be VBD cord-023134-y665agnh 187 21 collected collect VBN cord-023134-y665agnh 187 22 and and CC cord-023134-y665agnh 187 23 fixed fix VBN cord-023134-y665agnh 187 24 in in IN cord-023134-y665agnh 187 25 4 4 CD cord-023134-y665agnh 187 26 % % NN cord-023134-y665agnh 187 27 buffered buffer VBN cord-023134-y665agnh 187 28 formalin formalin NN cord-023134-y665agnh 187 29 . . . cord-023134-y665agnh 188 1 Based base VBN cord-023134-y665agnh 188 2 on on IN cord-023134-y665agnh 188 3 the the DT cord-023134-y665agnh 188 4 most most RBS cord-023134-y665agnh 188 5 recent recent JJ cord-023134-y665agnh 188 6 results result NNS cord-023134-y665agnh 188 7 from from IN cord-023134-y665agnh 188 8 cardiovascular cardiovascular JJ cord-023134-y665agnh 188 9 examination examination NN cord-023134-y665agnh 188 10 , , , cord-023134-y665agnh 188 11 five five CD cord-023134-y665agnh 188 12 groups group NNS cord-023134-y665agnh 188 13 were be VBD cord-023134-y665agnh 188 14 established establish VBN cord-023134-y665agnh 188 15 : : : cord-023134-y665agnh 188 16 normal normal JJ cord-023134-y665agnh 188 17 hearts heart NNS cord-023134-y665agnh 188 18 ( ( -LRB- cord-023134-y665agnh 188 19 group group NN cord-023134-y665agnh 188 20 1 1 CD cord-023134-y665agnh 188 21 , , , cord-023134-y665agnh 188 22 n=4 n=4 JJ cord-023134-y665agnh 188 23 ) ) -RRB- cord-023134-y665agnh 188 24 , , , cord-023134-y665agnh 188 25 DCM DCM NNP cord-023134-y665agnh 188 26 with with IN cord-023134-y665agnh 188 27 sinusrhythm sinusrhythm NNP cord-023134-y665agnh 188 28 ( ( -LRB- cord-023134-y665agnh 188 29 group group NNP cord-023134-y665agnh 188 30 2 2 CD cord-023134-y665agnh 188 31 ; ; : cord-023134-y665agnh 188 32 n=2 n=2 NNS cord-023134-y665agnh 188 33 ) ) -RRB- cord-023134-y665agnh 188 34 , , , cord-023134-y665agnh 188 35 DCM DCM NNP cord-023134-y665agnh 188 36 with with IN cord-023134-y665agnh 188 37 AF AF NNP cord-023134-y665agnh 188 38 ( ( -LRB- cord-023134-y665agnh 188 39 group group NN cord-023134-y665agnh 188 40 3 3 CD cord-023134-y665agnh 188 41 ; ; : cord-023134-y665agnh 188 42 n=6 n=6 NNP cord-023134-y665agnh 188 43 ) ) -RRB- cord-023134-y665agnh 188 44 , , , cord-023134-y665agnh 188 45 DCM DCM NNP cord-023134-y665agnh 188 46 with with IN cord-023134-y665agnh 188 47 AF AF NNP cord-023134-y665agnh 188 48 and and CC cord-023134-y665agnh 188 49 congestive congestive JJ cord-023134-y665agnh 188 50 heart heart NN cord-023134-y665agnh 188 51 failure failure NN cord-023134-y665agnh 188 52 ( ( -LRB- cord-023134-y665agnh 188 53 CHF CHF NNP cord-023134-y665agnh 188 54 ) ) -RRB- cord-023134-y665agnh 188 55 ( ( -LRB- cord-023134-y665agnh 188 56 group group NN cord-023134-y665agnh 188 57 4 4 CD cord-023134-y665agnh 188 58 ; ; : cord-023134-y665agnh 188 59 n=4 n=4 NNP cord-023134-y665agnh 188 60 ) ) -RRB- cord-023134-y665agnh 188 61 , , , cord-023134-y665agnh 188 62 AF AF NNP cord-023134-y665agnh 188 63 and and CC cord-023134-y665agnh 188 64 left leave VBD cord-023134-y665agnh 188 65 ventricular ventricular JJ cord-023134-y665agnh 188 66 reverse reverse JJ cord-023134-y665agnh 188 67 remodeling remodeling NN cord-023134-y665agnh 188 68 ( ( -LRB- cord-023134-y665agnh 188 69 LVRR LVRR NNP cord-023134-y665agnh 188 70 ) ) -RRB- cord-023134-y665agnh 188 71 due due IN cord-023134-y665agnh 188 72 to to IN cord-023134-y665agnh 188 73 medical medical JJ cord-023134-y665agnh 188 74 therapy therapy NN cord-023134-y665agnh 188 75 after after IN cord-023134-y665agnh 188 76 diagnosis diagnosis NN cord-023134-y665agnh 188 77 of of IN cord-023134-y665agnh 188 78 DCM DCM NNP cord-023134-y665agnh 188 79 ( ( -LRB- cord-023134-y665agnh 188 80 group group NN cord-023134-y665agnh 188 81 5 5 CD cord-023134-y665agnh 188 82 ; ; : cord-023134-y665agnh 189 1 n=3).All n=3).All NNP cord-023134-y665agnh 189 2 hearts heart NNS cord-023134-y665agnh 189 3 were be VBD cord-023134-y665agnh 189 4 evaluated evaluate VBN cord-023134-y665agnh 189 5 by by IN cord-023134-y665agnh 189 6 one one CD cord-023134-y665agnh 189 7 pathologist pathologist NN cord-023134-y665agnh 189 8 ( ( -LRB- cord-023134-y665agnh 189 9 1 1 LS cord-023134-y665agnh 189 10 ) ) -RRB- cord-023134-y665agnh 189 11 who who WP cord-023134-y665agnh 189 12 was be VBD cord-023134-y665agnh 189 13 blinded blind VBN cord-023134-y665agnh 189 14 to to IN cord-023134-y665agnh 189 15 the the DT cord-023134-y665agnh 189 16 clinical clinical JJ cord-023134-y665agnh 189 17 diagnosis diagnosis NN cord-023134-y665agnh 189 18 . . . cord-023134-y665agnh 190 1 Gross gross JJ cord-023134-y665agnh 190 2 inspection inspection NN cord-023134-y665agnh 190 3 included include VBD cord-023134-y665agnh 190 4 measurments measurment NNS cord-023134-y665agnh 190 5 of of IN cord-023134-y665agnh 190 6 weight weight NN cord-023134-y665agnh 190 7 , , , cord-023134-y665agnh 190 8 size size NN cord-023134-y665agnh 190 9 , , , cord-023134-y665agnh 190 10 and and CC cord-023134-y665agnh 190 11 architecture architecture NN cord-023134-y665agnh 190 12 of of IN cord-023134-y665agnh 190 13 left left NN cord-023134-y665agnh 190 14 ( ( -LRB- cord-023134-y665agnh 190 15 LV LV NNP cord-023134-y665agnh 190 16 ) ) -RRB- cord-023134-y665agnh 190 17 and and CC cord-023134-y665agnh 190 18 right right JJ cord-023134-y665agnh 190 19 ( ( -LRB- cord-023134-y665agnh 190 20 RV rv NN cord-023134-y665agnh 190 21 ) ) -RRB- cord-023134-y665agnh 190 22 ventricles ventricle NNS cord-023134-y665agnh 190 23 . . . cord-023134-y665agnh 191 1 Three three CD cord-023134-y665agnh 191 2 sites site NNS cord-023134-y665agnh 191 3 of of IN cord-023134-y665agnh 191 4 each each DT cord-023134-y665agnh 191 5 LV LV NNP cord-023134-y665agnh 191 6 , , , cord-023134-y665agnh 191 7 RV RV NNP cord-023134-y665agnh 191 8 , , , cord-023134-y665agnh 191 9 and and CC cord-023134-y665agnh 191 10 interventricular interventricular JJ cord-023134-y665agnh 191 11 septum septum NN cord-023134-y665agnh 191 12 ( ( -LRB- cord-023134-y665agnh 191 13 IVS IVS NNP cord-023134-y665agnh 191 14 ) ) -RRB- cord-023134-y665agnh 191 15 were be VBD cord-023134-y665agnh 191 16 histologically histologically RB cord-023134-y665agnh 191 17 evaluated evaluate VBN cord-023134-y665agnh 191 18 , , , cord-023134-y665agnh 191 19 and and CC cord-023134-y665agnh 191 20 the the DT cord-023134-y665agnh 191 21 extend extend NN cord-023134-y665agnh 191 22 of of IN cord-023134-y665agnh 191 23 myocardial myocardial JJ cord-023134-y665agnh 191 24 fibrosis fibrosis NN cord-023134-y665agnh 191 25 , , , cord-023134-y665agnh 191 26 adipocyte adipocyte NN cord-023134-y665agnh 191 27 infiltration infiltration NN cord-023134-y665agnh 191 28 , , , cord-023134-y665agnh 191 29 and and CC cord-023134-y665agnh 191 30 angiosclerosis angiosclerosis NN cord-023134-y665agnh 191 31 were be VBD cord-023134-y665agnh 191 32 graded grade VBN cord-023134-y665agnh 191 33 semiquantitatively semiquantitatively RB cord-023134-y665agnh 191 34 . . . cord-023134-y665agnh 192 1 IWs IWs NNP cord-023134-y665agnh 192 2 with with IN cord-023134-y665agnh 192 3 DCM DCM NNP cord-023134-y665agnh 192 4 and and CC cord-023134-y665agnh 192 5 CHF CHF NNP cord-023134-y665agnh 192 6 ( ( -LRB- cord-023134-y665agnh 192 7 group group NN cord-023134-y665agnh 192 8 4 4 CD cord-023134-y665agnh 192 9 ) ) -RRB- cord-023134-y665agnh 192 10 had have VBD cord-023134-y665agnh 192 11 died die VBN cord-023134-y665agnh 192 12 significantly significantly RB cord-023134-y665agnh 192 13 younger young JJR cord-023134-y665agnh 192 14 ( ( -LRB- cord-023134-y665agnh 192 15 5.0±2.0 5.0±2.0 CD cord-023134-y665agnh 192 16 years year NNS cord-023134-y665agnh 192 17 ) ) -RRB- cord-023134-y665agnh 192 18 than than IN cord-023134-y665agnh 192 19 dogs dog NNS cord-023134-y665agnh 192 20 with with IN cord-023134-y665agnh 192 21 normal normal JJ cord-023134-y665agnh 192 22 hearts heart NNS cord-023134-y665agnh 192 23 ( ( -LRB- cord-023134-y665agnh 192 24 7.0±1.9 7.0±1.9 CD cord-023134-y665agnh 192 25 years year NNS cord-023134-y665agnh 192 26 ) ) -RRB- cord-023134-y665agnh 193 1 ( ( -LRB- cord-023134-y665agnh 193 2 p=0.05 p=0.05 NNP cord-023134-y665agnh 193 3 ) ) -RRB- cord-023134-y665agnh 193 4 . . . cord-023134-y665agnh 194 1 Concerning concern VBG cord-023134-y665agnh 194 2 gross gross JJ cord-023134-y665agnh 194 3 pathology pathology NN cord-023134-y665agnh 194 4 findings finding NNS cord-023134-y665agnh 194 5 in in IN cord-023134-y665agnh 194 6 hearts heart NNS cord-023134-y665agnh 194 7 with with IN cord-023134-y665agnh 194 8 clinical clinical JJ cord-023134-y665agnh 194 9 DCM DCM NNP cord-023134-y665agnh 194 10 diagnosis diagnosis NN cord-023134-y665agnh 194 11 , , , cord-023134-y665agnh 194 12 LV LV NNP cord-023134-y665agnh 194 13 chambers chamber NNS cord-023134-y665agnh 194 14 were be VBD cord-023134-y665agnh 194 15 dilated dilate VBN cord-023134-y665agnh 194 16 in in IN cord-023134-y665agnh 194 17 3/4 3/4 CD cord-023134-y665agnh 194 18 cases case NNS cord-023134-y665agnh 194 19 of of IN cord-023134-y665agnh 194 20 group group NN cord-023134-y665agnh 194 21 4 4 CD cord-023134-y665agnh 194 22 , , , cord-023134-y665agnh 194 23 while while IN cord-023134-y665agnh 194 24 in in IN cord-023134-y665agnh 194 25 groups group NNS cord-023134-y665agnh 194 26 3 3 CD cord-023134-y665agnh 194 27 and and CC cord-023134-y665agnh 194 28 5 5 CD cord-023134-y665agnh 194 29 , , , cord-023134-y665agnh 194 30 the the DT cord-023134-y665agnh 194 31 papillary papillary JJ cord-023134-y665agnh 194 32 muscles muscle NNS cord-023134-y665agnh 194 33 appeared appear VBD cord-023134-y665agnh 194 34 grossly grossly RB cord-023134-y665agnh 194 35 prominent prominent JJ cord-023134-y665agnh 194 36 and and CC cord-023134-y665agnh 194 37 not not RB cord-023134-y665agnh 194 38 flattened flatten VBN cord-023134-y665agnh 194 39 as as IN cord-023134-y665agnh 194 40 in in IN cord-023134-y665agnh 194 41 group group NN cord-023134-y665agnh 194 42 4.Histopathologically 4.histopathologically CD cord-023134-y665agnh 194 43 , , , cord-023134-y665agnh 194 44 in in IN cord-023134-y665agnh 194 45 control control NN cord-023134-y665agnh 194 46 dogs dog NNS cord-023134-y665agnh 194 47 LV LV NNP cord-023134-y665agnh 194 48 and and CC cord-023134-y665agnh 194 49 RV RV NNP cord-023134-y665agnh 194 50 myocardium myocardium NN cord-023134-y665agnh 194 51 showed show VBD cord-023134-y665agnh 194 52 no no DT cord-023134-y665agnh 194 53 ( ( -LRB- cord-023134-y665agnh 194 54 3/4 3/4 CD cord-023134-y665agnh 194 55 ) ) -RRB- cord-023134-y665agnh 194 56 or or CC cord-023134-y665agnh 194 57 mild mild JJ cord-023134-y665agnh 194 58 ( ( -LRB- cord-023134-y665agnh 194 59 1/4 1/4 CD cord-023134-y665agnh 194 60 ) ) -RRB- cord-023134-y665agnh 194 61 interstitial interstitial JJ cord-023134-y665agnh 194 62 collagen collagen NN cord-023134-y665agnh 194 63 deposits deposit NNS cord-023134-y665agnh 194 64 , , , cord-023134-y665agnh 194 65 no no DT cord-023134-y665agnh 194 66 or or CC cord-023134-y665agnh 194 67 single single JJ cord-023134-y665agnh 194 68 adipocytes adipocyte NNS cord-023134-y665agnh 194 69 , , , cord-023134-y665agnh 194 70 and and CC cord-023134-y665agnh 194 71 normal normal JJ cord-023134-y665agnh 194 72 vessels vessel NNS cord-023134-y665agnh 194 73 . . . cord-023134-y665agnh 195 1 In in IN cord-023134-y665agnh 195 2 contrast contrast NN cord-023134-y665agnh 195 3 , , , cord-023134-y665agnh 195 4 heterogeneous heterogeneous JJ cord-023134-y665agnh 195 5 findings finding NNS cord-023134-y665agnh 195 6 were be VBD cord-023134-y665agnh 195 7 seen see VBN cord-023134-y665agnh 195 8 in in IN cord-023134-y665agnh 195 9 groups group NNS cord-023134-y665agnh 195 10 2 2 CD cord-023134-y665agnh 195 11 - - SYM cord-023134-y665agnh 195 12 5 5 CD cord-023134-y665agnh 195 13 : : : cord-023134-y665agnh 195 14 Most Most JJS cord-023134-y665agnh 195 15 hearts heart NNS cord-023134-y665agnh 195 16 ( ( -LRB- cord-023134-y665agnh 195 17 10/15 10/15 CD cord-023134-y665agnh 195 18 ) ) -RRB- cord-023134-y665agnh 195 19 showed show VBD cord-023134-y665agnh 195 20 mild mild JJ cord-023134-y665agnh 195 21 to to TO cord-023134-y665agnh 195 22 moderate moderate JJ cord-023134-y665agnh 195 23 multifocal multifocal JJ cord-023134-y665agnh 195 24 myocardial myocardial JJ cord-023134-y665agnh 195 25 fibrosis fibrosis NN cord-023134-y665agnh 195 26 and and CC cord-023134-y665agnh 195 27 up up IN cord-023134-y665agnh 195 28 to to TO cord-023134-y665agnh 195 29 moderate moderate VB cord-023134-y665agnh 195 30 diffuse diffuse JJ cord-023134-y665agnh 195 31 infiltration infiltration NN cord-023134-y665agnh 195 32 of of IN cord-023134-y665agnh 195 33 adipocytes adipocyte NNS cord-023134-y665agnh 195 34 within within IN cord-023134-y665agnh 195 35 the the DT cord-023134-y665agnh 195 36 LV LV NNP cord-023134-y665agnh 195 37 myocardium myocardium NN cord-023134-y665agnh 195 38 , , , cord-023134-y665agnh 195 39 and and CC cord-023134-y665agnh 195 40 mild mild JJ cord-023134-y665agnh 195 41 angiosclerosis angiosclerosis NN cord-023134-y665agnh 195 42 , , , cord-023134-y665agnh 195 43 but but CC cord-023134-y665agnh 195 44 five five CD cord-023134-y665agnh 195 45 hearts heart NNS cord-023134-y665agnh 195 46 were be VBD cord-023134-y665agnh 195 47 histologically histologically RB cord-023134-y665agnh 195 48 normal normal JJ cord-023134-y665agnh 195 49 . . . cord-023134-y665agnh 196 1 Only only RB cord-023134-y665agnh 196 2 in in IN cord-023134-y665agnh 196 3 one one CD cord-023134-y665agnh 196 4 dog dog NN cord-023134-y665agnh 196 5 attenuated attenuate VBN cord-023134-y665agnh 196 6 wavy wavy JJ cord-023134-y665agnh 196 7 fibers fiber NNS cord-023134-y665agnh 196 8 were be VBD cord-023134-y665agnh 196 9 seen see VBN cord-023134-y665agnh 196 10 in in IN cord-023134-y665agnh 196 11 the the DT cord-023134-y665agnh 196 12 apical apical JJ cord-023134-y665agnh 196 13 region region NN cord-023134-y665agnh 196 14 of of IN cord-023134-y665agnh 196 15 LV LV NNP cord-023134-y665agnh 196 16 . . . cord-023134-y665agnh 197 1 IVS IVS NNP cord-023134-y665agnh 197 2 was be VBD cord-023134-y665agnh 197 3 normal normal JJ cord-023134-y665agnh 197 4 in in IN cord-023134-y665agnh 197 5 9 9 CD cord-023134-y665agnh 197 6 out out IN cord-023134-y665agnh 197 7 of of IN cord-023134-y665agnh 197 8 15 15 CD cord-023134-y665agnh 197 9 cases case NNS cord-023134-y665agnh 197 10 . . . cord-023134-y665agnh 198 1 RV RV NNP cord-023134-y665agnh 198 2 showed show VBD cord-023134-y665agnh 198 3 mild mild JJ cord-023134-y665agnh 198 4 interstitial interstitial JJ cord-023134-y665agnh 198 5 fibrosis fibrosis NN cord-023134-y665agnh 198 6 and and CC cord-023134-y665agnh 198 7 mild mild JJ cord-023134-y665agnh 198 8 to to TO cord-023134-y665agnh 198 9 moderate moderate JJ cord-023134-y665agnh 198 10 adipocytes adipocyte NNS cord-023134-y665agnh 198 11 in in IN cord-023134-y665agnh 198 12 most most JJS cord-023134-y665agnh 198 13 cases case NNS cord-023134-y665agnh 198 14 ( ( -LRB- cord-023134-y665agnh 198 15 14/19 14/19 CD cord-023134-y665agnh 198 16 ) ) -RRB- cord-023134-y665agnh 198 17 of of IN cord-023134-y665agnh 198 18 all all DT cord-023134-y665agnh 198 19 groups group NNS cord-023134-y665agnh 198 20 . . . cord-023134-y665agnh 199 1 In in IN cord-023134-y665agnh 199 2 conclusion conclusion NN cord-023134-y665agnh 199 3 , , , cord-023134-y665agnh 199 4 pathological pathological JJ cord-023134-y665agnh 199 5 findings finding NNS cord-023134-y665agnh 199 6 in in IN cord-023134-y665agnh 199 7 hearts heart NNS cord-023134-y665agnh 199 8 of of IN cord-023134-y665agnh 199 9 IWs IWs NNP cord-023134-y665agnh 199 10 affected affect VBN cord-023134-y665agnh 199 11 with with IN cord-023134-y665agnh 199 12 DCM DCM NNP cord-023134-y665agnh 199 13 are be VBP cord-023134-y665agnh 199 14 different different JJ cord-023134-y665agnh 199 15 from from IN cord-023134-y665agnh 199 16 other other JJ cord-023134-y665agnh 199 17 breeds breed NNS cord-023134-y665agnh 199 18 . . . cord-023134-y665agnh 200 1 Furthermore furthermore RB cord-023134-y665agnh 200 2 , , , cord-023134-y665agnh 200 3 the the DT cord-023134-y665agnh 200 4 gross gross JJ cord-023134-y665agnh 200 5 and and CC cord-023134-y665agnh 200 6 histological histological JJ cord-023134-y665agnh 200 7 findings finding NNS cord-023134-y665agnh 200 8 are be VBP cord-023134-y665agnh 200 9 variable variable JJ cord-023134-y665agnh 200 10 and and CC cord-023134-y665agnh 200 11 do do VBP cord-023134-y665agnh 200 12 not not RB cord-023134-y665agnh 200 13 correspond correspond VB cord-023134-y665agnh 200 14 to to IN cord-023134-y665agnh 200 15 the the DT cord-023134-y665agnh 200 16 clinical clinical JJ cord-023134-y665agnh 200 17 diagnosis diagnosis NN cord-023134-y665agnh 200 18 in in IN cord-023134-y665agnh 200 19 all all DT cord-023134-y665agnh 200 20 cases case NNS cord-023134-y665agnh 200 21 . . . cord-023134-y665agnh 201 1 The the DT cord-023134-y665agnh 201 2 Irish irish JJ cord-023134-y665agnh 201 3 wolfhound wolfhound NN cord-023134-y665agnh 201 4 ( ( -LRB- cord-023134-y665agnh 201 5 IW IW NNP cord-023134-y665agnh 201 6 ) ) -RRB- cord-023134-y665agnh 201 7 dog dog NN cord-023134-y665agnh 201 8 has have VBZ cord-023134-y665agnh 201 9 a a DT cord-023134-y665agnh 201 10 high high JJ cord-023134-y665agnh 201 11 prevalence prevalence NN cord-023134-y665agnh 201 12 of of IN cord-023134-y665agnh 201 13 heart heart NN cord-023134-y665agnh 201 14 diseases disease NNS cord-023134-y665agnh 201 15 , , , cord-023134-y665agnh 201 16 particularly particularly RB cord-023134-y665agnh 201 17 dilated dilated JJ cord-023134-y665agnh 201 18 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 201 19 ( ( -LRB- cord-023134-y665agnh 201 20 DCM DCM NNP cord-023134-y665agnh 201 21 ) ) -RRB- cord-023134-y665agnh 201 22 and and CC cord-023134-y665agnh 201 23 atrial atrial JJ cord-023134-y665agnh 201 24 fibrillation fibrillation NN cord-023134-y665agnh 201 25 ( ( -LRB- cord-023134-y665agnh 201 26 AF AF NNP cord-023134-y665agnh 201 27 ) ) -RRB- cord-023134-y665agnh 201 28 . . . cord-023134-y665agnh 202 1 During during IN cord-023134-y665agnh 202 2 a a DT cord-023134-y665agnh 202 3 prospective prospective JJ cord-023134-y665agnh 202 4 longitudinal longitudinal JJ cord-023134-y665agnh 202 5 study study NN cord-023134-y665agnh 202 6 , , , cord-023134-y665agnh 202 7 1438 1438 CD cord-023134-y665agnh 202 8 Irish irish JJ cord-023134-y665agnh 202 9 wolfhounds wolfhound NNS cord-023134-y665agnh 202 10 were be VBD cord-023134-y665agnh 202 11 investigated investigate VBN cord-023134-y665agnh 202 12 by by IN cord-023134-y665agnh 202 13 one one CD cord-023134-y665agnh 202 14 veterinary veterinary JJ cord-023134-y665agnh 202 15 cardiologist cardiologist NN cord-023134-y665agnh 202 16 ( ( -LRB- cord-023134-y665agnh 202 17 2 2 CD cord-023134-y665agnh 202 18 ) ) -RRB- cord-023134-y665agnh 202 19 between between IN cord-023134-y665agnh 202 20 1990 1990 CD cord-023134-y665agnh 202 21 and and CC cord-023134-y665agnh 202 22 2012 2012 CD cord-023134-y665agnh 202 23 . . . cord-023134-y665agnh 203 1 DCM DCM NNP cord-023134-y665agnh 203 2 was be VBD cord-023134-y665agnh 203 3 diagnosed diagnose VBN cord-023134-y665agnh 203 4 in in IN cord-023134-y665agnh 203 5 about about RB cord-023134-y665agnh 203 6 26 26 CD cord-023134-y665agnh 203 7 % % NN cord-023134-y665agnh 203 8 of of IN cord-023134-y665agnh 203 9 dogs dog NNS cord-023134-y665agnh 203 10 . . . cord-023134-y665agnh 204 1 In in IN cord-023134-y665agnh 204 2 88 88 CD cord-023134-y665agnh 204 3 % % NN cord-023134-y665agnh 204 4 of of IN cord-023134-y665agnh 204 5 cases case NNS cord-023134-y665agnh 204 6 , , , cord-023134-y665agnh 204 7 DCM DCM NNP cord-023134-y665agnh 204 8 was be VBD cord-023134-y665agnh 204 9 accompanied accompany VBN cord-023134-y665agnh 204 10 by by IN cord-023134-y665agnh 204 11 AF AF NNP cord-023134-y665agnh 204 12 . . . cord-023134-y665agnh 205 1 In in IN cord-023134-y665agnh 205 2 addition addition NN cord-023134-y665agnh 205 3 , , , cord-023134-y665agnh 205 4 AF AF NNP cord-023134-y665agnh 205 5 without without IN cord-023134-y665agnh 205 6 evidence evidence NN cord-023134-y665agnh 205 7 of of IN cord-023134-y665agnh 205 8 DCM DCM NNP cord-023134-y665agnh 205 9 was be VBD cord-023134-y665agnh 205 10 diagnosed diagnose VBN cord-023134-y665agnh 205 11 in in IN cord-023134-y665agnh 205 12 31 31 CD cord-023134-y665agnh 205 13 dogs dog NNS cord-023134-y665agnh 205 14 ( ( -LRB- cord-023134-y665agnh 205 15 2%).For 2%).for CD cord-023134-y665agnh 205 16 pathological pathological JJ cord-023134-y665agnh 205 17 investigations investigation NNS cord-023134-y665agnh 205 18 , , , cord-023134-y665agnh 205 19 hearts heart NNS cord-023134-y665agnh 205 20 of of IN cord-023134-y665agnh 205 21 23 23 CD cord-023134-y665agnh 205 22 IWs IWs NNPS cord-023134-y665agnh 205 23 were be VBD cord-023134-y665agnh 205 24 collected collect VBN cord-023134-y665agnh 205 25 and and CC cord-023134-y665agnh 205 26 fixed fix VBN cord-023134-y665agnh 205 27 in in IN cord-023134-y665agnh 205 28 4 4 CD cord-023134-y665agnh 205 29 % % NN cord-023134-y665agnh 205 30 buffered buffer VBN cord-023134-y665agnh 205 31 formalin formalin NN cord-023134-y665agnh 205 32 . . . cord-023134-y665agnh 206 1 Based base VBN cord-023134-y665agnh 206 2 on on IN cord-023134-y665agnh 206 3 the the DT cord-023134-y665agnh 206 4 most most RBS cord-023134-y665agnh 206 5 recent recent JJ cord-023134-y665agnh 206 6 results result NNS cord-023134-y665agnh 206 7 from from IN cord-023134-y665agnh 206 8 cardiovascular cardiovascular JJ cord-023134-y665agnh 206 9 examination examination NN cord-023134-y665agnh 206 10 , , , cord-023134-y665agnh 206 11 three three CD cord-023134-y665agnh 206 12 groups group NNS cord-023134-y665agnh 206 13 were be VBD cord-023134-y665agnh 206 14 established establish VBN cord-023134-y665agnh 206 15 : : : cord-023134-y665agnh 206 16 DCM DCM NNP cord-023134-y665agnh 206 17 with with IN cord-023134-y665agnh 206 18 AF AF NNP cord-023134-y665agnh 206 19 ( ( -LRB- cord-023134-y665agnh 206 20 group group NN cord-023134-y665agnh 206 21 1 1 CD cord-023134-y665agnh 206 22 ; ; : cord-023134-y665agnh 206 23 n=12 n=12 NNP cord-023134-y665agnh 206 24 ) ) -RRB- cord-023134-y665agnh 207 1 , , , cord-023134-y665agnh 207 2 AF AF NNP cord-023134-y665agnh 207 3 without without IN cord-023134-y665agnh 207 4 evidence evidence NN cord-023134-y665agnh 207 5 of of IN cord-023134-y665agnh 207 6 DCM DCM NNP cord-023134-y665agnh 207 7 ( ( -LRB- cord-023134-y665agnh 207 8 group group NN cord-023134-y665agnh 207 9 2 2 CD cord-023134-y665agnh 207 10 ; ; : cord-023134-y665agnh 207 11 n=7 n=7 NNS cord-023134-y665agnh 207 12 ) ) -RRB- cord-023134-y665agnh 207 13 , , , cord-023134-y665agnh 207 14 normal normal JJ cord-023134-y665agnh 207 15 hearts heart NNS cord-023134-y665agnh 207 16 ( ( -LRB- cord-023134-y665agnh 207 17 group group NN cord-023134-y665agnh 207 18 3 3 CD cord-023134-y665agnh 207 19 , , , cord-023134-y665agnh 207 20 n=4).Aim n=4).Aim NNP cord-023134-y665agnh 207 21 of of IN cord-023134-y665agnh 207 22 this this DT cord-023134-y665agnh 207 23 study study NN cord-023134-y665agnh 207 24 was be VBD cord-023134-y665agnh 207 25 to to TO cord-023134-y665agnh 207 26 investigate investigate VB cord-023134-y665agnh 207 27 the the DT cord-023134-y665agnh 207 28 histopathological histopathological JJ cord-023134-y665agnh 207 29 findings finding NNS cord-023134-y665agnh 207 30 in in IN cord-023134-y665agnh 207 31 left left JJ cord-023134-y665agnh 207 32 and and CC cord-023134-y665agnh 207 33 right right JJ cord-023134-y665agnh 207 34 atria atria NN cord-023134-y665agnh 207 35 of of IN cord-023134-y665agnh 207 36 IWs IWs NNP cord-023134-y665agnh 207 37 with with IN cord-023134-y665agnh 207 38 atrial atrial JJ cord-023134-y665agnh 207 39 fibrillation fibrillation NN cord-023134-y665agnh 207 40 compared compare VBN cord-023134-y665agnh 207 41 to to IN cord-023134-y665agnh 207 42 normal normal JJ cord-023134-y665agnh 207 43 hearts heart NNS cord-023134-y665agnh 207 44 of of IN cord-023134-y665agnh 207 45 IWs IWs NNP cord-023134-y665agnh 207 46 . . . cord-023134-y665agnh 208 1 All all DT cord-023134-y665agnh 208 2 hearts heart NNS cord-023134-y665agnh 208 3 were be VBD cord-023134-y665agnh 208 4 evaluated evaluate VBN cord-023134-y665agnh 208 5 by by IN cord-023134-y665agnh 208 6 one one CD cord-023134-y665agnh 208 7 pathologist pathologist NN cord-023134-y665agnh 208 8 ( ( -LRB- cord-023134-y665agnh 208 9 1 1 LS cord-023134-y665agnh 208 10 ) ) -RRB- cord-023134-y665agnh 208 11 who who WP cord-023134-y665agnh 208 12 was be VBD cord-023134-y665agnh 208 13 blinded blind VBN cord-023134-y665agnh 208 14 to to IN cord-023134-y665agnh 208 15 the the DT cord-023134-y665agnh 208 16 clinical clinical JJ cord-023134-y665agnh 208 17 diagnosis diagnosis NN cord-023134-y665agnh 208 18 . . . cord-023134-y665agnh 209 1 Hearts heart NNS cord-023134-y665agnh 209 2 were be VBD cord-023134-y665agnh 209 3 inspected inspect VBN cord-023134-y665agnh 209 4 grossly grossly RB cord-023134-y665agnh 209 5 and and CC cord-023134-y665agnh 209 6 two two CD cord-023134-y665agnh 209 7 cross cross NN cord-023134-y665agnh 209 8 sections section NNS cord-023134-y665agnh 209 9 of of IN cord-023134-y665agnh 209 10 each each DT cord-023134-y665agnh 209 11 left left JJ cord-023134-y665agnh 209 12 ( ( -LRB- cord-023134-y665agnh 209 13 LAA LAA NNP cord-023134-y665agnh 209 14 ) ) -RRB- cord-023134-y665agnh 209 15 and and CC cord-023134-y665agnh 209 16 right right JJ cord-023134-y665agnh 209 17 ( ( -LRB- cord-023134-y665agnh 209 18 RAA RAA NNP cord-023134-y665agnh 209 19 ) ) -RRB- cord-023134-y665agnh 209 20 atrial atrial JJ cord-023134-y665agnh 209 21 appendage appendage NN cord-023134-y665agnh 209 22 were be VBD cord-023134-y665agnh 209 23 embedded embed VBN cord-023134-y665agnh 209 24 in in IN cord-023134-y665agnh 209 25 paraffin paraffin NN cord-023134-y665agnh 209 26 wax wax NN cord-023134-y665agnh 209 27 and and CC cord-023134-y665agnh 209 28 stained stain VBN cord-023134-y665agnh 209 29 with with IN cord-023134-y665agnh 209 30 H&E H&E NNP cord-023134-y665agnh 209 31 and and CC cord-023134-y665agnh 209 32 picrosirius picrosirius NN cord-023134-y665agnh 209 33 red red NN cord-023134-y665agnh 209 34 . . . cord-023134-y665agnh 210 1 Myocardial myocardial JJ cord-023134-y665agnh 210 2 fibrosis fibrosis NN cord-023134-y665agnh 210 3 and and CC cord-023134-y665agnh 210 4 adipocyte adipocyte NN cord-023134-y665agnh 210 5 infiltration infiltration NN cord-023134-y665agnh 210 6 in in IN cord-023134-y665agnh 210 7 both both DT cord-023134-y665agnh 210 8 atria atria NN cord-023134-y665agnh 210 9 were be VBD cord-023134-y665agnh 210 10 graded grade VBN cord-023134-y665agnh 210 11 semiquantitavely semiquantitavely RB cord-023134-y665agnh 210 12 . . . cord-023134-y665agnh 211 1 Mean mean JJ cord-023134-y665agnh 211 2 age age NN cord-023134-y665agnh 211 3 ± ± NNP cord-023134-y665agnh 211 4 SD sd NN cord-023134-y665agnh 211 5 of of IN cord-023134-y665agnh 211 6 all all DT cord-023134-y665agnh 211 7 dogs dog NNS cord-023134-y665agnh 211 8 at at IN cord-023134-y665agnh 211 9 time time NN cord-023134-y665agnh 211 10 of of IN cord-023134-y665agnh 211 11 death death NN cord-023134-y665agnh 211 12 was be VBD cord-023134-y665agnh 211 13 6,9 6,9 CD cord-023134-y665agnh 211 14 ± ± CD cord-023134-y665agnh 211 15 1.7 1.7 CD cord-023134-y665agnh 211 16 yrs yr NNS cord-023134-y665agnh 211 17 . . . cord-023134-y665agnh 212 1 The the DT cord-023134-y665agnh 212 2 gross gross JJ cord-023134-y665agnh 212 3 and and CC cord-023134-y665agnh 212 4 histopathological histopathological JJ cord-023134-y665agnh 212 5 findings finding NNS cord-023134-y665agnh 212 6 of of IN cord-023134-y665agnh 212 7 the the DT cord-023134-y665agnh 212 8 left left JJ cord-023134-y665agnh 212 9 atrial atrial JJ cord-023134-y665agnh 212 10 appendage appendage NN cord-023134-y665agnh 212 11 ( ( -LRB- cord-023134-y665agnh 212 12 LAA LAA NNP cord-023134-y665agnh 212 13 ) ) -RRB- cord-023134-y665agnh 212 14 were be VBD cord-023134-y665agnh 212 15 not not RB cord-023134-y665agnh 212 16 significantly significantly RB cord-023134-y665agnh 212 17 different different JJ cord-023134-y665agnh 212 18 among among IN cord-023134-y665agnh 212 19 groups group NNS cord-023134-y665agnh 212 20 , , , cord-023134-y665agnh 212 21 but but CC cord-023134-y665agnh 212 22 dogs dog NNS cord-023134-y665agnh 212 23 in in IN cord-023134-y665agnh 212 24 both both DT cord-023134-y665agnh 212 25 AF AF NNP cord-023134-y665agnh 212 26 groups group NNS cord-023134-y665agnh 212 27 had have VBD cord-023134-y665agnh 212 28 RAA RAA NNP cord-023134-y665agnh 212 29 dilation dilation NN cord-023134-y665agnh 212 30 ( ( -LRB- cord-023134-y665agnh 212 31 3.6 3.6 CD cord-023134-y665agnh 212 32 to to IN cord-023134-y665agnh 212 33 22.0 22.0 CD cord-023134-y665agnh 212 34 ml ml NNS cord-023134-y665agnh 212 35 , , , cord-023134-y665agnh 212 36 median median JJ cord-023134-y665agnh 212 37 11 11 CD cord-023134-y665agnh 212 38 ml ml NN cord-023134-y665agnh 212 39 volume volume NN cord-023134-y665agnh 212 40 ) ) -RRB- cord-023134-y665agnh 212 41 compared compare VBN cord-023134-y665agnh 212 42 to to IN cord-023134-y665agnh 212 43 controls control NNS cord-023134-y665agnh 212 44 ( ( -LRB- cord-023134-y665agnh 212 45 3.5 3.5 CD cord-023134-y665agnh 212 46 to to IN cord-023134-y665agnh 212 47 9.6 9.6 CD cord-023134-y665agnh 212 48 ml ml NN cord-023134-y665agnh 212 49 volume volume NN cord-023134-y665agnh 212 50 , , , cord-023134-y665agnh 212 51 median median NN cord-023134-y665agnh 212 52 5.34ml 5.34ml CD cord-023134-y665agnh 212 53 ) ) -RRB- cord-023134-y665agnh 212 54 . . . cord-023134-y665agnh 213 1 Histopathologically histopathologically RB cord-023134-y665agnh 213 2 , , , cord-023134-y665agnh 213 3 RAA RAA NNP cord-023134-y665agnh 213 4 in in IN cord-023134-y665agnh 213 5 control control NN cord-023134-y665agnh 213 6 dogs dog NNS cord-023134-y665agnh 213 7 showed show VBD cord-023134-y665agnh 213 8 small small JJ cord-023134-y665agnh 213 9 amounts amount NNS cord-023134-y665agnh 213 10 of of IN cord-023134-y665agnh 213 11 interstitialcollagen interstitialcollagen NNP cord-023134-y665agnh 213 12 and and CC cord-023134-y665agnh 213 13 single single JJ cord-023134-y665agnh 213 14 adipocytes adipocyte NNS cord-023134-y665agnh 213 15 . . . cord-023134-y665agnh 214 1 In in IN cord-023134-y665agnh 214 2 contrast contrast NN cord-023134-y665agnh 214 3 , , , cord-023134-y665agnh 214 4 RAA RAA NNP cord-023134-y665agnh 214 5 in in IN cord-023134-y665agnh 214 6 dogs dog NNS cord-023134-y665agnh 214 7 affected affect VBN cord-023134-y665agnh 214 8 with with IN cord-023134-y665agnh 214 9 AF AF NNP cord-023134-y665agnh 214 10 with with IN cord-023134-y665agnh 214 11 andwithout andwithout IN cord-023134-y665agnh 214 12 evidence evidence NN cord-023134-y665agnh 214 13 of of IN cord-023134-y665agnh 214 14 DCM DCM NNP cord-023134-y665agnh 214 15 , , , cord-023134-y665agnh 214 16 had have VBD cord-023134-y665agnh 214 17 mild mild JJ cord-023134-y665agnh 214 18 to to TO cord-023134-y665agnh 214 19 moderate moderate VB cord-023134-y665agnh 214 20 multifocal multifocal JJ cord-023134-y665agnh 214 21 or or CC cord-023134-y665agnh 214 22 diffuse diffuse VB cord-023134-y665agnh 214 23 myocardial myocardial JJ cord-023134-y665agnh 214 24 fibrosis fibrosis NN cord-023134-y665agnh 214 25 , , , cord-023134-y665agnh 214 26 and and CC cord-023134-y665agnh 214 27 diffuse diffuse VB cord-023134-y665agnh 214 28 infiltration infiltration NN cord-023134-y665agnh 214 29 of of IN cord-023134-y665agnh 214 30 adipocytes adipocyte NNS cord-023134-y665agnh 214 31 which which WDT cord-023134-y665agnh 214 32 was be VBD cord-023134-y665agnh 214 33 statistically statistically RB cord-023134-y665agnh 214 34 significant significant JJ cord-023134-y665agnh 214 35 different different JJ cord-023134-y665agnh 214 36 from from IN cord-023134-y665agnh 214 37 normal normal JJ cord-023134-y665agnh 214 38 hearts heart NNS cord-023134-y665agnh 214 39 ( ( -LRB- cord-023134-y665agnh 214 40 P=0.005 P=0.005 NNP cord-023134-y665agnh 214 41 ) ) -RRB- cord-023134-y665agnh 214 42 . . . cord-023134-y665agnh 215 1 In in IN cord-023134-y665agnh 215 2 general general JJ cord-023134-y665agnh 215 3 , , , cord-023134-y665agnh 215 4 fibrosis fibrosis NN cord-023134-y665agnh 215 5 and and CC cord-023134-y665agnh 215 6 number number NN cord-023134-y665agnh 215 7 of of IN cord-023134-y665agnh 215 8 adipocytes adipocyte NNS cord-023134-y665agnh 215 9 were be VBD cord-023134-y665agnh 215 10 significantly significantly RB cord-023134-y665agnh 215 11 increased increase VBN cord-023134-y665agnh 215 12 in in IN cord-023134-y665agnh 215 13 RAA RAA NNP cord-023134-y665agnh 215 14 compared compare VBN cord-023134-y665agnh 215 15 to to IN cord-023134-y665agnh 215 16 LAA LAA NNP cord-023134-y665agnh 215 17 in in IN cord-023134-y665agnh 215 18 both both DT cord-023134-y665agnh 215 19 groups group NNS cord-023134-y665agnh 215 20 with with IN cord-023134-y665agnh 215 21 AF AF NNP cord-023134-y665agnh 215 22 ( ( -LRB- cord-023134-y665agnh 215 23 P=0.014).Fibrosis P=0.014).Fibrosis NNP cord-023134-y665agnh 215 24 and and CC cord-023134-y665agnh 215 25 the the DT cord-023134-y665agnh 215 26 accumulation accumulation NN cord-023134-y665agnh 215 27 of of IN cord-023134-y665agnh 215 28 adipocytes adipocyte NNS cord-023134-y665agnh 215 29 within within IN cord-023134-y665agnh 215 30 the the DT cord-023134-y665agnh 215 31 myocardium myocardium NN cord-023134-y665agnh 215 32 are be VBP cord-023134-y665agnh 215 33 described describe VBN cord-023134-y665agnh 215 34 toresult toresult NNS cord-023134-y665agnh 215 35 in in IN cord-023134-y665agnh 215 36 electrical electrical JJ cord-023134-y665agnh 215 37 inhomogeneity inhomogeneity NN cord-023134-y665agnh 215 38 predisposing predispose VBG cord-023134-y665agnh 215 39 to to IN cord-023134-y665agnh 215 40 arrhythmia arrhythmia NN cord-023134-y665agnh 215 41 . . . cord-023134-y665agnh 216 1 On on IN cord-023134-y665agnh 216 2 a a DT cord-023134-y665agnh 216 3 cellular cellular JJ cord-023134-y665agnh 216 4 level level NN cord-023134-y665agnh 216 5 , , , cord-023134-y665agnh 216 6 right right JJ cord-023134-y665agnh 216 7 atrial atrial JJ cord-023134-y665agnh 216 8 fibrosis fibrosis NN cord-023134-y665agnh 216 9 and and CC cord-023134-y665agnh 216 10 adipocyte adipocyte NN cord-023134-y665agnh 216 11 accumulation accumulation NN cord-023134-y665agnh 216 12 might may MD cord-023134-y665agnh 216 13 be be VB cord-023134-y665agnh 216 14 the the DT cord-023134-y665agnh 216 15 changes change NNS cord-023134-y665agnh 216 16 responsible responsible JJ cord-023134-y665agnh 216 17 for for IN cord-023134-y665agnh 216 18 the the DT cord-023134-y665agnh 216 19 development development NN cord-023134-y665agnh 216 20 of of IN cord-023134-y665agnh 216 21 atrial atrial JJ cord-023134-y665agnh 216 22 fibrillation fibrillation NN cord-023134-y665agnh 216 23 and and CC cord-023134-y665agnh 216 24 atrial atrial JJ cord-023134-y665agnh 216 25 dilatation dilatation NN cord-023134-y665agnh 216 26 in in IN cord-023134-y665agnh 216 27 this this DT cord-023134-y665agnh 216 28 breed breed NN cord-023134-y665agnh 216 29 of of IN cord-023134-y665agnh 216 30 dogs dog NNS cord-023134-y665agnh 216 31 with with IN cord-023134-y665agnh 216 32 an an DT cord-023134-y665agnh 216 33 exceptional exceptional JJ cord-023134-y665agnh 216 34 high high JJ cord-023134-y665agnh 216 35 prevalence prevalence NN cord-023134-y665agnh 216 36 of of IN cord-023134-y665agnh 216 37 AF AF NNP cord-023134-y665agnh 216 38 and and CC cord-023134-y665agnh 216 39 DCM DCM NNP cord-023134-y665agnh 216 40 . . . cord-023134-y665agnh 217 1 Asynchronous asynchronous JJ cord-023134-y665agnh 217 2 ventricular ventricular JJ cord-023134-y665agnh 217 3 contraction contraction NN cord-023134-y665agnh 217 4 causes cause VBZ cord-023134-y665agnh 217 5 deterioration deterioration NN cord-023134-y665agnh 217 6 in in IN cord-023134-y665agnh 217 7 cardiac cardiac JJ cord-023134-y665agnh 217 8 function function NN cord-023134-y665agnh 217 9 and and CC cord-023134-y665agnh 217 10 reduces reduce VBZ cord-023134-y665agnh 217 11 the the DT cord-023134-y665agnh 217 12 response response NN cord-023134-y665agnh 217 13 to to IN cord-023134-y665agnh 217 14 medical medical JJ cord-023134-y665agnh 217 15 therapy therapy NN cord-023134-y665agnh 217 16 in in IN cord-023134-y665agnh 217 17 people people NNS cord-023134-y665agnh 217 18 with with IN cord-023134-y665agnh 217 19 heart heart NN cord-023134-y665agnh 217 20 disease disease NN cord-023134-y665agnh 217 21 . . . cord-023134-y665agnh 218 1 Various various JJ cord-023134-y665agnh 218 2 echocardiographic echocardiographic JJ cord-023134-y665agnh 218 3 techniques technique NNS cord-023134-y665agnh 218 4 have have VBP cord-023134-y665agnh 218 5 been be VBN cord-023134-y665agnh 218 6 used use VBN cord-023134-y665agnh 218 7 in in IN cord-023134-y665agnh 218 8 humans human NNS cord-023134-y665agnh 218 9 for for IN cord-023134-y665agnh 218 10 evaluation evaluation NN cord-023134-y665agnh 218 11 of of IN cord-023134-y665agnh 218 12 left left JJ cord-023134-y665agnh 218 13 ventricular ventricular JJ cord-023134-y665agnh 218 14 ( ( -LRB- cord-023134-y665agnh 218 15 LV LV NNP cord-023134-y665agnh 218 16 ) ) -RRB- cord-023134-y665agnh 218 17 synchronization synchronization NN cord-023134-y665agnh 218 18 in in IN cord-023134-y665agnh 218 19 order order NN cord-023134-y665agnh 218 20 to to TO cord-023134-y665agnh 218 21 assess assess VB cord-023134-y665agnh 218 22 whether whether IN cord-023134-y665agnh 218 23 cardiac cardiac JJ cord-023134-y665agnh 218 24 resynchronization resynchronization NN cord-023134-y665agnh 218 25 therapy therapy NN cord-023134-y665agnh 218 26 ( ( -LRB- cord-023134-y665agnh 218 27 CRT CRT NNP cord-023134-y665agnh 218 28 ) ) -RRB- cord-023134-y665agnh 218 29 would would MD cord-023134-y665agnh 218 30 be be VB cord-023134-y665agnh 218 31 beneficial beneficial JJ cord-023134-y665agnh 218 32 . . . cord-023134-y665agnh 219 1 Prior prior JJ cord-023134-y665agnh 219 2 studies study NNS cord-023134-y665agnh 219 3 using use VBG cord-023134-y665agnh 219 4 tissue tissue NN cord-023134-y665agnh 219 5 Doppler doppler NN cord-023134-y665agnh 219 6 imaging imaging NN cord-023134-y665agnh 219 7 ( ( -LRB- cord-023134-y665agnh 219 8 TDI TDI NNP cord-023134-y665agnh 219 9 ) ) -RRB- cord-023134-y665agnh 219 10 derived derive VBD cord-023134-y665agnh 219 11 strain strain NN cord-023134-y665agnh 219 12 imaging imaging NN cord-023134-y665agnh 219 13 have have VBP cord-023134-y665agnh 219 14 not not RB cord-023134-y665agnh 219 15 detected detect VBN cord-023134-y665agnh 219 16 LV LV NNP cord-023134-y665agnh 219 17 dyssynchronization dyssynchronization NN cord-023134-y665agnh 219 18 in in IN cord-023134-y665agnh 219 19 Doberman Doberman NNP cord-023134-y665agnh 219 20 Pinschers Pinschers NNPS cord-023134-y665agnh 219 21 with with IN cord-023134-y665agnh 219 22 dilated dilated JJ cord-023134-y665agnh 219 23 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 219 24 ( ( -LRB- cord-023134-y665agnh 219 25 DCM DCM NNP cord-023134-y665agnh 219 26 ) ) -RRB- cord-023134-y665agnh 219 27 . . . cord-023134-y665agnh 220 1 A a DT cord-023134-y665agnh 220 2 newer new JJR cord-023134-y665agnh 220 3 2D 2d NN cord-023134-y665agnh 220 4 imaging imaging NN cord-023134-y665agnh 220 5 modality modality NN cord-023134-y665agnh 220 6 , , , cord-023134-y665agnh 220 7 speckle speckle NN cord-023134-y665agnh 220 8 tracking tracking NN cord-023134-y665agnh 220 9 strain strain NN cord-023134-y665agnh 220 10 analysis analysis NN cord-023134-y665agnh 220 11 , , , cord-023134-y665agnh 220 12 is be VBZ cord-023134-y665agnh 220 13 more more RBR cord-023134-y665agnh 220 14 effective effective JJ cord-023134-y665agnh 220 15 in in IN cord-023134-y665agnh 220 16 detecting detect VBG cord-023134-y665agnh 220 17 LV LV NNP cord-023134-y665agnh 220 18 dyssynchrony dyssynchrony NN cord-023134-y665agnh 220 19 in in IN cord-023134-y665agnh 220 20 humans human NNS cord-023134-y665agnh 220 21 . . . cord-023134-y665agnh 221 1 This this DT cord-023134-y665agnh 221 2 technique technique NN cord-023134-y665agnh 221 3 has have VBZ cord-023134-y665agnh 221 4 not not RB cord-023134-y665agnh 221 5 been be VBN cord-023134-y665agnh 221 6 previously previously RB cord-023134-y665agnh 221 7 evaluated evaluate VBN cord-023134-y665agnh 221 8 in in IN cord-023134-y665agnh 221 9 Doberman Doberman NNP cord-023134-y665agnh 221 10 Pinschers Pinschers NNPS cord-023134-y665agnh 221 11 with with IN cord-023134-y665agnh 221 12 DCM DCM NNP cord-023134-y665agnh 221 13 . . . cord-023134-y665agnh 222 1 This this DT cord-023134-y665agnh 222 2 study study NN cord-023134-y665agnh 222 3 therefore therefore RB cord-023134-y665agnh 222 4 aims aim VBZ cord-023134-y665agnh 222 5 to to TO cord-023134-y665agnh 222 6 evaluate evaluate VB cord-023134-y665agnh 222 7 LV LV NNP cord-023134-y665agnh 222 8 synchrony synchrony NN cord-023134-y665agnh 222 9 in in IN cord-023134-y665agnh 222 10 Doberman Doberman NNP cord-023134-y665agnh 222 11 Pinschers Pinschers NNPS cord-023134-y665agnh 222 12 with with IN cord-023134-y665agnh 222 13 DCM DCM NNP cord-023134-y665agnh 222 14 using use VBG cord-023134-y665agnh 222 15 2D 2D NNP cord-023134-y665agnh 222 16 speckle speckle NN cord-023134-y665agnh 222 17 tracking tracking NN cord-023134-y665agnh 222 18 strain strain NN cord-023134-y665agnh 222 19 . . . cord-023134-y665agnh 223 1 52 52 CD cord-023134-y665agnh 223 2 client client NN cord-023134-y665agnh 223 3 - - HYPH cord-023134-y665agnh 223 4 owned own VBN cord-023134-y665agnh 223 5 Doberman Doberman NNP cord-023134-y665agnh 223 6 Pinschers Pinschers NNPS cord-023134-y665agnh 223 7 were be VBD cord-023134-y665agnh 223 8 included include VBN cord-023134-y665agnh 223 9 . . . cord-023134-y665agnh 224 1 Standard standard JJ cord-023134-y665agnh 224 2 echocardiography echocardiography NN cord-023134-y665agnh 224 3 was be VBD cord-023134-y665agnh 224 4 used use VBN cord-023134-y665agnh 224 5 to to TO cord-023134-y665agnh 224 6 evaluate evaluate VB cord-023134-y665agnh 224 7 systolic systolic JJ cord-023134-y665agnh 224 8 function function NN cord-023134-y665agnh 224 9 and and CC cord-023134-y665agnh 224 10 left leave VBN cord-023134-y665agnh 224 11 ventricular ventricular JJ cord-023134-y665agnh 224 12 dimension dimension NN cord-023134-y665agnh 224 13 in in IN cord-023134-y665agnh 224 14 order order NN cord-023134-y665agnh 224 15 to to TO cord-023134-y665agnh 224 16 categorize categorize VB cord-023134-y665agnh 224 17 the the DT cord-023134-y665agnh 224 18 dogs dog NNS cord-023134-y665agnh 224 19 as as IN cord-023134-y665agnh 224 20 normal normal JJ cord-023134-y665agnh 224 21 or or CC cord-023134-y665agnh 224 22 abnormal abnormal JJ cord-023134-y665agnh 224 23 , , , cord-023134-y665agnh 224 24 depending depend VBG cord-023134-y665agnh 224 25 on on IN cord-023134-y665agnh 224 26 systolic systolic JJ cord-023134-y665agnh 224 27 and and CC cord-023134-y665agnh 224 28 diastolic diastolic JJ cord-023134-y665agnh 224 29 ventricular ventricular JJ cord-023134-y665agnh 224 30 dimensions dimension NNS cord-023134-y665agnh 224 31 , , , cord-023134-y665agnh 224 32 ejection ejection NN cord-023134-y665agnh 224 33 fraction fraction NN cord-023134-y665agnh 224 34 and/or and/or CC cord-023134-y665agnh 224 35 shortening shorten VBG cord-023134-y665agnh 224 36 fraction fraction NN cord-023134-y665agnh 224 37 . . . cord-023134-y665agnh 225 1 The the DT cord-023134-y665agnh 225 2 operator operator NN cord-023134-y665agnh 225 3 was be VBD cord-023134-y665agnh 225 4 blinded blind VBN cord-023134-y665agnh 225 5 to to IN cord-023134-y665agnh 225 6 the the DT cord-023134-y665agnh 225 7 echocardiographic echocardiographic JJ cord-023134-y665agnh 225 8 diagnosis diagnosis NN cord-023134-y665agnh 225 9 of of IN cord-023134-y665agnh 225 10 each each DT cord-023134-y665agnh 225 11 dog dog NN cord-023134-y665agnh 225 12 . . . cord-023134-y665agnh 226 1 Each each DT cord-023134-y665agnh 226 2 parameter parameter NN cord-023134-y665agnh 226 3 was be VBD cord-023134-y665agnh 226 4 measured measure VBN cord-023134-y665agnh 226 5 in in IN cord-023134-y665agnh 226 6 triplicate triplicate NN cord-023134-y665agnh 226 7 . . . cord-023134-y665agnh 227 1 Radial radial JJ cord-023134-y665agnh 227 2 ( ( -LRB- cord-023134-y665agnh 227 3 RS rs NN cord-023134-y665agnh 227 4 ) ) -RRB- cord-023134-y665agnh 227 5 and and CC cord-023134-y665agnh 227 6 circumferential circumferential JJ cord-023134-y665agnh 227 7 strain strain NN cord-023134-y665agnh 227 8 ( ( -LRB- cord-023134-y665agnh 227 9 CS CS NNP cord-023134-y665agnh 227 10 ) ) -RRB- cord-023134-y665agnh 227 11 , , , cord-023134-y665agnh 227 12 using use VBG cord-023134-y665agnh 227 13 right right JJ cord-023134-y665agnh 227 14 parasternal parasternal JJ cord-023134-y665agnh 227 15 short short JJ cord-023134-y665agnh 227 16 axis axis NN cord-023134-y665agnh 227 17 at at IN cord-023134-y665agnh 227 18 the the DT cord-023134-y665agnh 227 19 level level NN cord-023134-y665agnh 227 20 of of IN cord-023134-y665agnh 227 21 the the DT cord-023134-y665agnh 227 22 papillary papillary JJ cord-023134-y665agnh 227 23 muscles muscle NNS cord-023134-y665agnh 227 24 were be VBD cord-023134-y665agnh 227 25 calculated calculate VBN cord-023134-y665agnh 227 26 . . . cord-023134-y665agnh 228 1 Synchrony Synchrony NNP cord-023134-y665agnh 228 2 was be VBD cord-023134-y665agnh 228 3 assessed assess VBN cord-023134-y665agnh 228 4 by by IN cord-023134-y665agnh 228 5 measuring measure VBG cord-023134-y665agnh 228 6 the the DT cord-023134-y665agnh 228 7 difference difference NN cord-023134-y665agnh 228 8 in in IN cord-023134-y665agnh 228 9 the the DT cord-023134-y665agnh 228 10 QRS qrs NN cord-023134-y665agnh 228 11 onset onset NN cord-023134-y665agnh 228 12 time time NN cord-023134-y665agnh 228 13 - - HYPH cord-023134-y665agnh 228 14 to to IN cord-023134-y665agnh 228 15 - - HYPH cord-023134-y665agnh 228 16 peak peak NN cord-023134-y665agnh 228 17 strain strain NN cord-023134-y665agnh 228 18 between between IN cord-023134-y665agnh 228 19 the the DT cord-023134-y665agnh 228 20 septal septal JJ cord-023134-y665agnh 228 21 anterior anterior NN cord-023134-y665agnh 228 22 and and CC cord-023134-y665agnh 228 23 posterior posterior JJ cord-023134-y665agnh 228 24 left leave VBD cord-023134-y665agnh 228 25 ventricular ventricular JJ cord-023134-y665agnh 228 26 segments segment NNS cord-023134-y665agnh 228 27 . . . cord-023134-y665agnh 229 1 To to TO cord-023134-y665agnh 229 2 evaluate evaluate VB cord-023134-y665agnh 229 3 differences difference NNS cord-023134-y665agnh 229 4 between between IN cord-023134-y665agnh 229 5 groups group NNS cord-023134-y665agnh 229 6 a a DT cord-023134-y665agnh 229 7 nested nested JJ cord-023134-y665agnh 229 8 effect effect NN cord-023134-y665agnh 229 9 ANOVA ANOVA NNP cord-023134-y665agnh 229 10 ( ( -LRB- cord-023134-y665agnh 229 11 beat beat VBN cord-023134-y665agnh 229 12 within within IN cord-023134-y665agnh 229 13 group group NN cord-023134-y665agnh 229 14 ) ) -RRB- cord-023134-y665agnh 229 15 was be VBD cord-023134-y665agnh 229 16 performed perform VBN cord-023134-y665agnh 229 17 . . . cord-023134-y665agnh 230 1 A a DT cord-023134-y665agnh 230 2 p<0.005 p<0.005 NN cord-023134-y665agnh 230 3 was be VBD cord-023134-y665agnh 230 4 considered consider VBN cord-023134-y665agnh 230 5 significant significant JJ cord-023134-y665agnh 230 6 . . . cord-023134-y665agnh 231 1 Based base VBN cord-023134-y665agnh 231 2 on on IN cord-023134-y665agnh 231 3 the the DT cord-023134-y665agnh 231 4 echocardiographic echocardiographic JJ cord-023134-y665agnh 231 5 parameters parameter NNS cord-023134-y665agnh 231 6 mentioned mention VBN cord-023134-y665agnh 231 7 above above RB cord-023134-y665agnh 231 8 , , , cord-023134-y665agnh 231 9 19/52 19/52 CD cord-023134-y665agnh 231 10 dogs dog NNS cord-023134-y665agnh 231 11 were be VBD cord-023134-y665agnh 231 12 considered consider VBN cord-023134-y665agnh 231 13 normal normal JJ cord-023134-y665agnh 231 14 and and CC cord-023134-y665agnh 231 15 33/52 33/52 CD cord-023134-y665agnh 231 16 had have VBD cord-023134-y665agnh 231 17 DCM DCM NNP cord-023134-y665agnh 231 18 . . . cord-023134-y665agnh 232 1 Significant significant JJ cord-023134-y665agnh 232 2 differences difference NNS cord-023134-y665agnh 232 3 were be VBD cord-023134-y665agnh 232 4 found find VBN cord-023134-y665agnh 232 5 in in IN cord-023134-y665agnh 232 6 the the DT cord-023134-y665agnh 232 7 time time NN cord-023134-y665agnh 232 8 to to TO cord-023134-y665agnh 232 9 peak peak VB cord-023134-y665agnh 232 10 RS RS NNP cord-023134-y665agnh 232 11 ( ( -LRB- cord-023134-y665agnh 232 12 P= P= NNP cord-023134-y665agnh 232 13 0.0009 0.0009 CD cord-023134-y665agnh 232 14 ) ) -RRB- cord-023134-y665agnh 232 15 between between IN cord-023134-y665agnh 232 16 normal normal JJ cord-023134-y665agnh 232 17 dogs dog NNS cord-023134-y665agnh 232 18 and and CC cord-023134-y665agnh 232 19 dogs dog NNS cord-023134-y665agnh 232 20 affected affect VBN cord-023134-y665agnh 232 21 with with IN cord-023134-y665agnh 232 22 DCM DCM NNP cord-023134-y665agnh 232 23 . . . cord-023134-y665agnh 233 1 Mean mean VB cord-023134-y665agnh 233 2 in in IN cord-023134-y665agnh 233 3 time time NN cord-023134-y665agnh 233 4 to to TO cord-023134-y665agnh 233 5 peak peak VB cord-023134-y665agnh 233 6 RS RS NNP cord-023134-y665agnh 233 7 was be VBD cord-023134-y665agnh 233 8 43.8 43.8 CD cord-023134-y665agnh 233 9 ms ms NNP cord-023134-y665agnh 233 10 ( ( -LRB- cord-023134-y665agnh 233 11 + + CC cord-023134-y665agnh 233 12 /-35.8 /-35.8 NNP cord-023134-y665agnh 233 13 ) ) -RRB- cord-023134-y665agnh 233 14 in in IN cord-023134-y665agnh 233 15 normal normal JJ cord-023134-y665agnh 233 16 dogs dog NNS cord-023134-y665agnh 233 17 and and CC cord-023134-y665agnh 233 18 69.21 69.21 CD cord-023134-y665agnh 233 19 ms ms NNP cord-023134-y665agnh 233 20 ( ( -LRB- cord-023134-y665agnh 233 21 + + CD cord-023134-y665agnh 233 22 /-48.9 /-48.9 NNP cord-023134-y665agnh 233 23 ) ) -RRB- cord-023134-y665agnh 233 24 in in IN cord-023134-y665agnh 233 25 dogs dog NNS cord-023134-y665agnh 233 26 with with IN cord-023134-y665agnh 233 27 DCM DCM NNP cord-023134-y665agnh 233 28 . . . cord-023134-y665agnh 234 1 Time time NN cord-023134-y665agnh 234 2 to to TO cord-023134-y665agnh 234 3 peak peak VB cord-023134-y665agnh 234 4 CS CS NNP cord-023134-y665agnh 234 5 did do VBD cord-023134-y665agnh 234 6 not not RB cord-023134-y665agnh 234 7 exhibit exhibit VB cord-023134-y665agnh 234 8 significant significant JJ cord-023134-y665agnh 234 9 differences difference NNS cord-023134-y665agnh 234 10 between between IN cord-023134-y665agnh 234 11 groups group NNS cord-023134-y665agnh 234 12 ( ( -LRB- cord-023134-y665agnh 234 13 P= p= NN cord-023134-y665agnh 234 14 0.62 0.62 CD cord-023134-y665agnh 234 15 ) ) -RRB- cord-023134-y665agnh 234 16 and and CC cord-023134-y665agnh 234 17 was be VBD cord-023134-y665agnh 234 18 55.6 55.6 CD cord-023134-y665agnh 234 19 ms ms NNP cord-023134-y665agnh 234 20 ( ( -LRB- cord-023134-y665agnh 234 21 + + `` cord-023134-y665agnh 234 22 /-49.91 /-49.91 NNP cord-023134-y665agnh 234 23 ) ) -RRB- cord-023134-y665agnh 234 24 in in IN cord-023134-y665agnh 234 25 normal normal JJ cord-023134-y665agnh 234 26 dogs dog NNS cord-023134-y665agnh 234 27 and and CC cord-023134-y665agnh 234 28 60.66 60.66 CD cord-023134-y665agnh 234 29 ms ms NNP cord-023134-y665agnh 234 30 ( ( -LRB- cord-023134-y665agnh 234 31 + + CC cord-023134-y665agnh 234 32 /-63.2 /-63.2 NNP cord-023134-y665agnh 234 33 ) ) -RRB- cord-023134-y665agnh 234 34 in in IN cord-023134-y665agnh 234 35 dogs dog NNS cord-023134-y665agnh 234 36 with with IN cord-023134-y665agnh 234 37 DCM DCM NNP cord-023134-y665agnh 234 38 . . . cord-023134-y665agnh 235 1 The the DT cord-023134-y665agnh 235 2 results result NNS cord-023134-y665agnh 235 3 of of IN cord-023134-y665agnh 235 4 this this DT cord-023134-y665agnh 235 5 study study NN cord-023134-y665agnh 235 6 show show VBP cord-023134-y665agnh 235 7 that that IN cord-023134-y665agnh 235 8 the the DT cord-023134-y665agnh 235 9 delay delay NN cord-023134-y665agnh 235 10 between between IN cord-023134-y665agnh 235 11 the the DT cord-023134-y665agnh 235 12 anteroseptal anteroseptal JJ cord-023134-y665agnh 235 13 - - HYPH cord-023134-y665agnh 235 14 to to IN cord-023134-y665agnh 235 15 - - HYPH cord-023134-y665agnh 235 16 posterior posterior JJ cord-023134-y665agnh 235 17 wall wall NN cord-023134-y665agnh 235 18 peak peak NN cord-023134-y665agnh 235 19 radial radial JJ cord-023134-y665agnh 235 20 strain strain NN cord-023134-y665agnh 235 21 is be VBZ cord-023134-y665agnh 235 22 greater great JJR cord-023134-y665agnh 235 23 in in IN cord-023134-y665agnh 235 24 Doberman Doberman NNP cord-023134-y665agnh 235 25 Pinschers Pinschers NNPS cord-023134-y665agnh 235 26 with with IN cord-023134-y665agnh 235 27 DCM DCM NNP cord-023134-y665agnh 235 28 than than IN cord-023134-y665agnh 235 29 in in IN cord-023134-y665agnh 235 30 normal normal JJ cord-023134-y665agnh 235 31 dogs dog NNS cord-023134-y665agnh 235 32 . . . cord-023134-y665agnh 236 1 Further further JJ cord-023134-y665agnh 236 2 studies study NNS cord-023134-y665agnh 236 3 would would MD cord-023134-y665agnh 236 4 be be VB cord-023134-y665agnh 236 5 required require VBN cord-023134-y665agnh 236 6 to to TO cord-023134-y665agnh 236 7 evaluate evaluate VB cord-023134-y665agnh 236 8 whether whether IN cord-023134-y665agnh 236 9 there there EX cord-023134-y665agnh 236 10 is be VBZ cord-023134-y665agnh 236 11 a a DT cord-023134-y665agnh 236 12 difference difference NN cord-023134-y665agnh 236 13 in in IN cord-023134-y665agnh 236 14 synchrony synchrony NN cord-023134-y665agnh 236 15 between between IN cord-023134-y665agnh 236 16 dogs dog NNS cord-023134-y665agnh 236 17 in in IN cord-023134-y665agnh 236 18 occult occult JJ cord-023134-y665agnh 236 19 stage stage NN cord-023134-y665agnh 236 20 and and CC cord-023134-y665agnh 236 21 overt overt JJ cord-023134-y665agnh 236 22 DCM DCM NNP cord-023134-y665agnh 236 23 . . . cord-023134-y665agnh 237 1 Ventricular ventricular JJ cord-023134-y665agnh 237 2 dyssynchrony dyssynchrony NN cord-023134-y665agnh 237 3 could could MD cord-023134-y665agnh 237 4 negatively negatively RB cord-023134-y665agnh 237 5 affect affect VB cord-023134-y665agnh 237 6 systolic systolic JJ cord-023134-y665agnh 237 7 dysfunction dysfunction NN cord-023134-y665agnh 237 8 as as IN cord-023134-y665agnh 237 9 it -PRON- PRP cord-023134-y665agnh 237 10 does do VBZ cord-023134-y665agnh 237 11 in in IN cord-023134-y665agnh 237 12 people people NNS cord-023134-y665agnh 237 13 , , , cord-023134-y665agnh 237 14 and and CC cord-023134-y665agnh 237 15 CRT CRT NNP cord-023134-y665agnh 237 16 may may MD cord-023134-y665agnh 237 17 therefore therefore RB cord-023134-y665agnh 237 18 be be VB cord-023134-y665agnh 237 19 helpful helpful JJ cord-023134-y665agnh 237 20 for for IN cord-023134-y665agnh 237 21 the the DT cord-023134-y665agnh 237 22 treatment treatment NN cord-023134-y665agnh 237 23 of of IN cord-023134-y665agnh 237 24 Dobermans Dobermans NNPS cord-023134-y665agnh 237 25 with with IN cord-023134-y665agnh 237 26 DCM DCM NNP cord-023134-y665agnh 237 27 . . . cord-023134-y665agnh 238 1 Patent patent NN cord-023134-y665agnh 238 2 ductus ductus NN cord-023134-y665agnh 238 3 arteriosus arteriosus NN cord-023134-y665agnh 238 4 is be VBZ cord-023134-y665agnh 238 5 often often RB cord-023134-y665agnh 238 6 treated treat VBN cord-023134-y665agnh 238 7 with with IN cord-023134-y665agnh 238 8 intra intra JJ cord-023134-y665agnh 238 9 - - JJ cord-023134-y665agnh 238 10 arterial arterial JJ cord-023134-y665agnh 238 11 coilembolization coilembolization NN cord-023134-y665agnh 238 12 or or CC cord-023134-y665agnh 238 13 implantation implantation NN cord-023134-y665agnh 238 14 of of IN cord-023134-y665agnh 238 15 an an DT cord-023134-y665agnh 238 16 ' ' `` cord-023134-y665agnh 238 17 Amplatz Amplatz NNP cord-023134-y665agnh 238 18 Canine canine JJ cord-023134-y665agnh 238 19 Duct duct NN cord-023134-y665agnh 238 20 - - HYPH cord-023134-y665agnh 238 21 Occluder Occluder NNP cord-023134-y665agnh 238 22 ' ' '' cord-023134-y665agnh 238 23 . . . cord-023134-y665agnh 239 1 For for IN cord-023134-y665agnh 239 2 both both DT cord-023134-y665agnh 239 3 procedures procedure NNS cord-023134-y665agnh 239 4 an an DT cord-023134-y665agnh 239 5 arterial arterial JJ cord-023134-y665agnh 239 6 access access NN cord-023134-y665agnh 239 7 is be VBZ cord-023134-y665agnh 239 8 necessary necessary JJ cord-023134-y665agnh 239 9 . . . cord-023134-y665agnh 240 1 Because because IN cord-023134-y665agnh 240 2 of of IN cord-023134-y665agnh 240 3 the the DT cord-023134-y665agnh 240 4 high high JJ cord-023134-y665agnh 240 5 risk risk NN cord-023134-y665agnh 240 6 of of IN cord-023134-y665agnh 240 7 developing develop VBG cord-023134-y665agnh 240 8 a a DT cord-023134-y665agnh 240 9 fatal fatal JJ cord-023134-y665agnh 240 10 hemorrhage hemorrhage NN cord-023134-y665agnh 240 11 from from IN cord-023134-y665agnh 240 12 the the DT cord-023134-y665agnh 240 13 arterial arterial JJ cord-023134-y665agnh 240 14 puncture puncture NN cord-023134-y665agnh 240 15 site site NN cord-023134-y665agnh 240 16 after after IN cord-023134-y665agnh 240 17 removal removal NN cord-023134-y665agnh 240 18 of of IN cord-023134-y665agnh 240 19 the the DT cord-023134-y665agnh 240 20 large large JJ cord-023134-y665agnh 240 21 - - HYPH cord-023134-y665agnh 240 22 bore bore NN cord-023134-y665agnh 240 23 introducer introducer NN cord-023134-y665agnh 240 24 sheath sheath NN cord-023134-y665agnh 240 25 upon upon IN cord-023134-y665agnh 240 26 completing complete VBG cord-023134-y665agnh 240 27 the the DT cord-023134-y665agnh 240 28 intervention intervention NN cord-023134-y665agnh 240 29 , , , cord-023134-y665agnh 240 30 cardiologists cardiologist NNS cord-023134-y665agnh 240 31 generally generally RB cord-023134-y665agnh 240 32 use use VBP cord-023134-y665agnh 240 33 surgical surgical JJ cord-023134-y665agnh 240 34 cut cut NN cord-023134-y665agnh 240 35 - - HYPH cord-023134-y665agnh 240 36 down down NN cord-023134-y665agnh 240 37 with with IN cord-023134-y665agnh 240 38 subsequent subsequent JJ cord-023134-y665agnh 240 39 ligation ligation NN cord-023134-y665agnh 240 40 of of IN cord-023134-y665agnh 240 41 the the DT cord-023134-y665agnh 240 42 femoral femoral JJ cord-023134-y665agnh 240 43 artery artery NN cord-023134-y665agnh 240 44 instead instead RB cord-023134-y665agnh 240 45 of of IN cord-023134-y665agnh 241 1 percutaneous percutaneous JJ cord-023134-y665agnh 241 2 arterial arterial JJ cord-023134-y665agnh 241 3 puncture puncture NN cord-023134-y665agnh 241 4 using use VBG cord-023134-y665agnh 241 5 Seldinger Seldinger NNP cord-023134-y665agnh 241 6 's 's POS cord-023134-y665agnh 241 7 technique technique NN cord-023134-y665agnh 241 8 . . . cord-023134-y665agnh 242 1 The the DT cord-023134-y665agnh 242 2 effect effect NN cord-023134-y665agnh 242 3 of of IN cord-023134-y665agnh 242 4 commercially commercially RB cord-023134-y665agnh 242 5 available available JJ cord-023134-y665agnh 242 6 chitosan chitosan NN cord-023134-y665agnh 242 7 patch patch NN cord-023134-y665agnh 242 8 has have VBZ cord-023134-y665agnh 242 9 been be VBN cord-023134-y665agnh 242 10 tested test VBN cord-023134-y665agnh 242 11 in in IN cord-023134-y665agnh 242 12 10 10 CD cord-023134-y665agnh 242 13 experimental experimental JJ cord-023134-y665agnh 242 14 dogs dog NNS cord-023134-y665agnh 242 15 with with IN cord-023134-y665agnh 242 16 the the DT cord-023134-y665agnh 242 17 approval approval NN cord-023134-y665agnh 242 18 of of IN cord-023134-y665agnh 242 19 the the DT cord-023134-y665agnh 242 20 institute institute NN cord-023134-y665agnh 242 21 's 's POS cord-023134-y665agnh 242 22 ethical ethical JJ cord-023134-y665agnh 242 23 committee committee NN cord-023134-y665agnh 242 24 . . . cord-023134-y665agnh 243 1 On on IN cord-023134-y665agnh 243 2 the the DT cord-023134-y665agnh 243 3 first first JJ cord-023134-y665agnh 243 4 4 4 CD cord-023134-y665agnh 243 5 beagles beagle NNS cord-023134-y665agnh 243 6 the the DT cord-023134-y665agnh 243 7 committee committee NN cord-023134-y665agnh 243 8 required require VBD cord-023134-y665agnh 243 9 a a DT cord-023134-y665agnh 243 10 terminal terminal JJ cord-023134-y665agnh 243 11 experiment experiment NN cord-023134-y665agnh 243 12 . . . cord-023134-y665agnh 244 1 For for IN cord-023134-y665agnh 244 2 the the DT cord-023134-y665agnh 244 3 selection selection NN cord-023134-y665agnh 244 4 of of IN cord-023134-y665agnh 244 5 an an DT cord-023134-y665agnh 244 6 appropriate appropriate JJ cord-023134-y665agnh 244 7 introducer introducer NN cord-023134-y665agnh 244 8 - - HYPH cord-023134-y665agnh 244 9 sheath sheath NN cord-023134-y665agnh 244 10 ( ( -LRB- cord-023134-y665agnh 244 11 i.e. i.e. FW cord-023134-y665agnh 244 12 smaller small JJR cord-023134-y665agnh 244 13 than than IN cord-023134-y665agnh 244 14 the the DT cord-023134-y665agnh 244 15 arterial arterial JJ cord-023134-y665agnh 244 16 diameter diameter NN cord-023134-y665agnh 244 17 ) ) -RRB- cord-023134-y665agnh 244 18 , , , cord-023134-y665agnh 244 19 the the DT cord-023134-y665agnh 244 20 femoral femoral JJ cord-023134-y665agnh 244 21 artery artery NN cord-023134-y665agnh 244 22 was be VBD cord-023134-y665agnh 244 23 first first RB cord-023134-y665agnh 244 24 imaged image VBN cord-023134-y665agnh 244 25 with with IN cord-023134-y665agnh 244 26 ultrasound ultrasound NN cord-023134-y665agnh 244 27 . . . cord-023134-y665agnh 245 1 Under under IN cord-023134-y665agnh 245 2 general general JJ cord-023134-y665agnh 245 3 anesthesia anesthesia NN cord-023134-y665agnh 245 4 introducer introducer NN cord-023134-y665agnh 245 5 - - HYPH cord-023134-y665agnh 245 6 sheaths sheath NNS cord-023134-y665agnh 245 7 were be VBD cord-023134-y665agnh 245 8 placed place VBN cord-023134-y665agnh 245 9 in in IN cord-023134-y665agnh 245 10 both both DT cord-023134-y665agnh 245 11 femoral femoral JJ cord-023134-y665agnh 245 12 arteries artery NNS cord-023134-y665agnh 245 13 using use VBG cord-023134-y665agnh 245 14 Seldinger Seldinger NNP cord-023134-y665agnh 245 15 's 's POS cord-023134-y665agnh 245 16 technique technique NN cord-023134-y665agnh 245 17 . . . cord-023134-y665agnh 246 1 After after IN cord-023134-y665agnh 246 2 their -PRON- PRP$ cord-023134-y665agnh 246 3 removal removal NN cord-023134-y665agnh 246 4 a a DT cord-023134-y665agnh 246 5 chitosan chitosan NN cord-023134-y665agnh 246 6 - - HYPH cord-023134-y665agnh 246 7 patch patch NN cord-023134-y665agnh 246 8 was be VBD cord-023134-y665agnh 246 9 applied apply VBN cord-023134-y665agnh 246 10 on on IN cord-023134-y665agnh 246 11 the the DT cord-023134-y665agnh 246 12 wound wound NN cord-023134-y665agnh 246 13 according accord VBG cord-023134-y665agnh 246 14 to to IN cord-023134-y665agnh 246 15 the the DT cord-023134-y665agnh 246 16 manufacturer manufacturer NN cord-023134-y665agnh 246 17 's 's POS cord-023134-y665agnh 246 18 instructions instruction NNS cord-023134-y665agnh 246 19 : : : cord-023134-y665agnh 246 20 10-minute 10-minute CD cord-023134-y665agnh 246 21 manual manual JJ cord-023134-y665agnh 246 22 pressure pressure NN cord-023134-y665agnh 246 23 . . . cord-023134-y665agnh 247 1 The the DT cord-023134-y665agnh 247 2 dogs dog NNS cord-023134-y665agnh 247 3 were be VBD cord-023134-y665agnh 247 4 monitored monitor VBN cord-023134-y665agnh 247 5 with with IN cord-023134-y665agnh 247 6 direct direct JJ cord-023134-y665agnh 247 7 arterial arterial JJ cord-023134-y665agnh 247 8 blood blood NN cord-023134-y665agnh 247 9 pressure pressure NN cord-023134-y665agnh 247 10 measurement measurement NN cord-023134-y665agnh 247 11 , , , cord-023134-y665agnh 247 12 ECG ECG NNP cord-023134-y665agnh 247 13 , , , cord-023134-y665agnh 247 14 pulse pulse NN cord-023134-y665agnh 247 15 oxymetry oxymetry NNP cord-023134-y665agnh 247 16 and and CC cord-023134-y665agnh 247 17 capnography capnography NN cord-023134-y665agnh 247 18 . . . cord-023134-y665agnh 248 1 All all DT cord-023134-y665agnh 248 2 4 4 CD cord-023134-y665agnh 248 3 dogs dog NNS cord-023134-y665agnh 248 4 were be VBD cord-023134-y665agnh 248 5 kept keep VBN cord-023134-y665agnh 248 6 under under IN cord-023134-y665agnh 248 7 general general JJ cord-023134-y665agnh 248 8 anesthesia anesthesia NN cord-023134-y665agnh 248 9 for for IN cord-023134-y665agnh 248 10 several several JJ cord-023134-y665agnh 248 11 hours hour NNS cord-023134-y665agnh 248 12 and and CC cord-023134-y665agnh 248 13 the the DT cord-023134-y665agnh 248 14 legs leg NNS cord-023134-y665agnh 248 15 were be VBD cord-023134-y665agnh 248 16 moved move VBN cord-023134-y665agnh 248 17 vigorously vigorously RB cord-023134-y665agnh 248 18 every every DT cord-023134-y665agnh 248 19 30 30 CD cord-023134-y665agnh 248 20 minutes minute NNS cord-023134-y665agnh 248 21 to to TO cord-023134-y665agnh 248 22 mimic mimic VB cord-023134-y665agnh 248 23 movements movement NNS cord-023134-y665agnh 248 24 of of IN cord-023134-y665agnh 248 25 awake awake JJ cord-023134-y665agnh 248 26 animals animal NNS cord-023134-y665agnh 248 27 . . . cord-023134-y665agnh 249 1 No no DT cord-023134-y665agnh 249 2 macroscopic macroscopic JJ cord-023134-y665agnh 249 3 hemorrhage hemorrhage NN cord-023134-y665agnh 249 4 was be VBD cord-023134-y665agnh 249 5 noticed notice VBN cord-023134-y665agnh 249 6 on on IN cord-023134-y665agnh 249 7 the the DT cord-023134-y665agnh 249 8 8 8 CD cord-023134-y665agnh 249 9 puncture puncture NN cord-023134-y665agnh 249 10 sites site NNS cord-023134-y665agnh 249 11 and and CC cord-023134-y665agnh 249 12 no no DT cord-023134-y665agnh 249 13 signs sign NNS cord-023134-y665agnh 249 14 of of IN cord-023134-y665agnh 249 15 severe severe JJ cord-023134-y665agnh 249 16 subcutaneous subcutaneous JJ cord-023134-y665agnh 249 17 bleeding bleeding NN cord-023134-y665agnh 249 18 was be VBD cord-023134-y665agnh 249 19 suspected suspect VBN cord-023134-y665agnh 249 20 as as IN cord-023134-y665agnh 249 21 the the DT cord-023134-y665agnh 249 22 blood blood NN cord-023134-y665agnh 249 23 pressure pressure NN cord-023134-y665agnh 249 24 and and CC cord-023134-y665agnh 249 25 heart heart NN cord-023134-y665agnh 249 26 rate rate NN cord-023134-y665agnh 249 27 remained remain VBD cord-023134-y665agnh 249 28 stable stable JJ cord-023134-y665agnh 249 29 . . . cord-023134-y665agnh 250 1 After after IN cord-023134-y665agnh 250 2 several several JJ cord-023134-y665agnh 250 3 hours hour NNS cord-023134-y665agnh 250 4 the the DT cord-023134-y665agnh 250 5 dogs dog NNS cord-023134-y665agnh 250 6 were be VBD cord-023134-y665agnh 250 7 euthanized euthanize VBN cord-023134-y665agnh 250 8 . . . cord-023134-y665agnh 251 1 After after IN cord-023134-y665agnh 251 2 having have VBG cord-023134-y665agnh 251 3 shown show VBN cord-023134-y665agnh 251 4 the the DT cord-023134-y665agnh 251 5 effective effective JJ cord-023134-y665agnh 251 6 working working NN cord-023134-y665agnh 251 7 of of IN cord-023134-y665agnh 251 8 chitosan chitosan NN cord-023134-y665agnh 251 9 - - HYPH cord-023134-y665agnh 251 10 patch patch NN cord-023134-y665agnh 251 11 , , , cord-023134-y665agnh 251 12 a a DT cord-023134-y665agnh 251 13 permission permission NN cord-023134-y665agnh 251 14 was be VBD cord-023134-y665agnh 251 15 granted grant VBN cord-023134-y665agnh 251 16 for for IN cord-023134-y665agnh 251 17 survival survival NN cord-023134-y665agnh 251 18 experiments experiment NNS cord-023134-y665agnh 251 19 in in IN cord-023134-y665agnh 251 20 4 4 CD cord-023134-y665agnh 251 21 beagles beagle NNS cord-023134-y665agnh 251 22 . . . cord-023134-y665agnh 252 1 In in IN cord-023134-y665agnh 252 2 2 2 CD cord-023134-y665agnh 252 3 of of IN cord-023134-y665agnh 252 4 these these DT cord-023134-y665agnh 252 5 dogs dog NNS cord-023134-y665agnh 252 6 one one CD cord-023134-y665agnh 252 7 femoral femoral JJ cord-023134-y665agnh 252 8 artery artery NN cord-023134-y665agnh 252 9 was be VBD cord-023134-y665agnh 252 10 punctured puncture VBN cord-023134-y665agnh 252 11 with with IN cord-023134-y665agnh 252 12 an an DT cord-023134-y665agnh 252 13 introducer introducer NN cord-023134-y665agnh 252 14 whose whose WP$ cord-023134-y665agnh 252 15 thickness thickness NN cord-023134-y665agnh 252 16 exceeded exceed VBD cord-023134-y665agnh 252 17 the the DT cord-023134-y665agnh 252 18 diameter diameter NN cord-023134-y665agnh 252 19 of of IN cord-023134-y665agnh 252 20 the the DT cord-023134-y665agnh 252 21 femoral femoral JJ cord-023134-y665agnh 252 22 artery artery NN cord-023134-y665agnh 252 23 . . . cord-023134-y665agnh 253 1 In in IN cord-023134-y665agnh 253 2 both both DT cord-023134-y665agnh 253 3 dogs dog NNS cord-023134-y665agnh 253 4 an an DT cord-023134-y665agnh 253 5 uncontrollable uncontrollable JJ cord-023134-y665agnh 253 6 subcutaneous subcutaneous JJ cord-023134-y665agnh 253 7 hemorrhage hemorrhage NN cord-023134-y665agnh 253 8 occurred occur VBD cord-023134-y665agnh 253 9 immediately immediately RB cord-023134-y665agnh 253 10 after after IN cord-023134-y665agnh 253 11 the the DT cord-023134-y665agnh 253 12 10-minute 10-minute JJ cord-023134-y665agnh 253 13 manual manual JJ cord-023134-y665agnh 253 14 compression compression NN cord-023134-y665agnh 253 15 time time NN cord-023134-y665agnh 253 16 with with IN cord-023134-y665agnh 253 17 severe severe JJ cord-023134-y665agnh 253 18 drop drop NN cord-023134-y665agnh 253 19 of of IN cord-023134-y665agnh 253 20 blood blood NN cord-023134-y665agnh 253 21 pressure pressure NN cord-023134-y665agnh 253 22 and and CC cord-023134-y665agnh 253 23 development development NN cord-023134-y665agnh 253 24 of of IN cord-023134-y665agnh 253 25 tachycardia tachycardia NN cord-023134-y665agnh 253 26 . . . cord-023134-y665agnh 254 1 Both both DT cord-023134-y665agnh 254 2 dogs dog NNS cord-023134-y665agnh 254 3 were be VBD cord-023134-y665agnh 254 4 euthanized euthanize VBN cord-023134-y665agnh 254 5 during during IN cord-023134-y665agnh 254 6 anesthesia anesthesia NN cord-023134-y665agnh 254 7 . . . cord-023134-y665agnh 255 1 In in IN cord-023134-y665agnh 255 2 another another DT cord-023134-y665agnh 255 3 2 2 CD cord-023134-y665agnh 255 4 beagles beagle NNS cord-023134-y665agnh 255 5 the the DT cord-023134-y665agnh 255 6 size size NN cord-023134-y665agnh 255 7 of of IN cord-023134-y665agnh 255 8 the the DT cord-023134-y665agnh 255 9 introducer introducer NN cord-023134-y665agnh 255 10 was be VBD cord-023134-y665agnh 255 11 smaller small JJR cord-023134-y665agnh 255 12 than than IN cord-023134-y665agnh 255 13 the the DT cord-023134-y665agnh 255 14 diameter diameter NN cord-023134-y665agnh 255 15 of of IN cord-023134-y665agnh 255 16 the the DT cord-023134-y665agnh 255 17 artery artery NN cord-023134-y665agnh 255 18 ( ( -LRB- cord-023134-y665agnh 255 19 80 80 CD cord-023134-y665agnh 255 20 - - SYM cord-023134-y665agnh 255 21 100 100 CD cord-023134-y665agnh 255 22 % % NN cord-023134-y665agnh 255 23 ) ) -RRB- cord-023134-y665agnh 255 24 . . . cord-023134-y665agnh 256 1 No no DT cord-023134-y665agnh 256 2 relevant relevant JJ cord-023134-y665agnh 256 3 hemorrhage hemorrhage NN cord-023134-y665agnh 256 4 took take VBD cord-023134-y665agnh 256 5 place place NN cord-023134-y665agnh 256 6 in in IN cord-023134-y665agnh 256 7 these these DT cord-023134-y665agnh 256 8 dogs dog NNS cord-023134-y665agnh 256 9 and and CC cord-023134-y665agnh 256 10 they -PRON- PRP cord-023134-y665agnh 256 11 recovered recover VBD cord-023134-y665agnh 256 12 from from IN cord-023134-y665agnh 256 13 the the DT cord-023134-y665agnh 256 14 procedure procedure NN cord-023134-y665agnh 256 15 without without IN cord-023134-y665agnh 256 16 any any DT cord-023134-y665agnh 256 17 complications complication NNS cord-023134-y665agnh 256 18 . . . cord-023134-y665agnh 257 1 Similarly similarly RB cord-023134-y665agnh 257 2 good good JJ cord-023134-y665agnh 257 3 outcome outcome NN cord-023134-y665agnh 257 4 was be VBD cord-023134-y665agnh 257 5 found find VBN cord-023134-y665agnh 257 6 in in IN cord-023134-y665agnh 257 7 two two CD cord-023134-y665agnh 257 8 9-month 9-month JJ cord-023134-y665agnh 257 9 - - HYPH cord-023134-y665agnh 257 10 old old JJ cord-023134-y665agnh 257 11 Boerboels Boerboels NNPS cord-023134-y665agnh 257 12 . . . cord-023134-y665agnh 258 1 From from IN cord-023134-y665agnh 258 2 this this DT cord-023134-y665agnh 258 3 pilot pilot NN cord-023134-y665agnh 258 4 study study NN cord-023134-y665agnh 258 5 we -PRON- PRP cord-023134-y665agnh 258 6 concluded conclude VBD cord-023134-y665agnh 258 7 that that IN cord-023134-y665agnh 258 8 chitosan chitosan NN cord-023134-y665agnh 258 9 - - HYPH cord-023134-y665agnh 258 10 patch patch NN cord-023134-y665agnh 258 11 can can MD cord-023134-y665agnh 258 12 effectively effectively RB cord-023134-y665agnh 258 13 control control VB cord-023134-y665agnh 258 14 hemorrhage hemorrhage NN cord-023134-y665agnh 258 15 from from IN cord-023134-y665agnh 258 16 a a DT cord-023134-y665agnh 258 17 femoral femoral JJ cord-023134-y665agnh 258 18 arterial arterial JJ cord-023134-y665agnh 258 19 puncture puncture NN cord-023134-y665agnh 258 20 site site NN cord-023134-y665agnh 258 21 if if IN cord-023134-y665agnh 258 22 the the DT cord-023134-y665agnh 258 23 introducer introducer NN cord-023134-y665agnh 258 24 - - HYPH cord-023134-y665agnh 258 25 sheath sheath NN cord-023134-y665agnh 258 26 is be VBZ cord-023134-y665agnh 258 27 thinner thin JJR cord-023134-y665agnh 258 28 than than IN cord-023134-y665agnh 258 29 the the DT cord-023134-y665agnh 258 30 artery artery NN cord-023134-y665agnh 258 31 's 's POS cord-023134-y665agnh 258 32 lumen lumen NN cord-023134-y665agnh 258 33 . . . cord-023134-y665agnh 259 1 Using use VBG cord-023134-y665agnh 259 2 Seldinger Seldinger NNP cord-023134-y665agnh 259 3 's 's POS cord-023134-y665agnh 259 4 technique technique NN cord-023134-y665agnh 259 5 allows allow VBZ cord-023134-y665agnh 259 6 a a DT cord-023134-y665agnh 259 7 less less RBR cord-023134-y665agnh 259 8 invasive invasive JJ cord-023134-y665agnh 259 9 and and CC cord-023134-y665agnh 259 10 quicker quick JJR cord-023134-y665agnh 259 11 cardiac cardiac JJ cord-023134-y665agnh 259 12 catheterization catheterization NN cord-023134-y665agnh 259 13 and and CC cord-023134-y665agnh 259 14 preservation preservation NN cord-023134-y665agnh 259 15 of of IN cord-023134-y665agnh 259 16 the the DT cord-023134-y665agnh 259 17 femoral femoral JJ cord-023134-y665agnh 259 18 artery artery NN cord-023134-y665agnh 259 19 for for IN cord-023134-y665agnh 259 20 the the DT cord-023134-y665agnh 259 21 leg leg NN cord-023134-y665agnh 259 22 's 's POS cord-023134-y665agnh 259 23 blood blood NN cord-023134-y665agnh 259 24 supply supply NN cord-023134-y665agnh 259 25 and and CC cord-023134-y665agnh 259 26 for for IN cord-023134-y665agnh 259 27 repeated repeat VBN cord-023134-y665agnh 259 28 intra intra JJ cord-023134-y665agnh 259 29 - - JJ cord-023134-y665agnh 259 30 arterial arterial JJ cord-023134-y665agnh 259 31 interventions intervention NNS cord-023134-y665agnh 259 32 . . . cord-023134-y665agnh 260 1 Objectives objective NNS cord-023134-y665agnh 260 2 were be VBD cord-023134-y665agnh 260 3 to to TO cord-023134-y665agnh 260 4 examine examine VB cord-023134-y665agnh 260 5 longitudinal longitudinal JJ cord-023134-y665agnh 260 6 change change NN cord-023134-y665agnh 260 7 in in IN cord-023134-y665agnh 260 8 echocardiographic echocardiographic NNP cord-023134-y665agnh 260 9 left leave VBD cord-023134-y665agnh 260 10 heart heart NN cord-023134-y665agnh 260 11 chamber chamber NN cord-023134-y665agnh 260 12 dimensions dimension NNS cord-023134-y665agnh 260 13 and and CC cord-023134-y665agnh 260 14 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 260 15 classification classification NN cord-023134-y665agnh 260 16 in in IN cord-023134-y665agnh 260 17 cats cat NNS cord-023134-y665agnh 260 18 with with IN cord-023134-y665agnh 260 19 primary primary JJ cord-023134-y665agnh 260 20 myocardial myocardial JJ cord-023134-y665agnh 260 21 disease disease NN cord-023134-y665agnh 260 22 . . . cord-023134-y665agnh 261 1 Clinical clinical JJ cord-023134-y665agnh 261 2 records record NNS cord-023134-y665agnh 261 3 from from IN cord-023134-y665agnh 261 4 2004 2004 CD cord-023134-y665agnh 261 5 - - SYM cord-023134-y665agnh 261 6 2012 2012 CD cord-023134-y665agnh 261 7 were be VBD cord-023134-y665agnh 261 8 reviewed review VBN cord-023134-y665agnh 261 9 for for IN cord-023134-y665agnh 261 10 cats cat NNS cord-023134-y665agnh 261 11 with with IN cord-023134-y665agnh 261 12 2 2 CD cord-023134-y665agnh 261 13 or or CC cord-023134-y665agnh 261 14 more more JJR cord-023134-y665agnh 261 15 echocardiographic echocardiographic JJ cord-023134-y665agnh 261 16 examinations examination NNS cord-023134-y665agnh 261 17 at at IN cord-023134-y665agnh 261 18 least least JJS cord-023134-y665agnh 261 19 6 6 CD cord-023134-y665agnh 261 20 months month NNS cord-023134-y665agnh 261 21 apart apart RB cord-023134-y665agnh 261 22 and and CC cord-023134-y665agnh 261 23 a a DT cord-023134-y665agnh 261 24 diagnosis diagnosis NN cord-023134-y665agnh 261 25 of of IN cord-023134-y665agnh 261 26 primary primary JJ cord-023134-y665agnh 261 27 myocardial myocardial JJ cord-023134-y665agnh 261 28 disease disease NN cord-023134-y665agnh 261 29 . . . cord-023134-y665agnh 262 1 For for IN cord-023134-y665agnh 262 2 each each DT cord-023134-y665agnh 262 3 study study NN cord-023134-y665agnh 262 4 ( ( -LRB- cord-023134-y665agnh 262 5 2 2 CD cord-023134-y665agnh 262 6 from from IN cord-023134-y665agnh 262 7 each each DT cord-023134-y665agnh 262 8 cat cat NN cord-023134-y665agnh 262 9 ) ) -RRB- cord-023134-y665agnh 262 10 , , , cord-023134-y665agnh 262 11 left leave VBD cord-023134-y665agnh 262 12 heart heart NN cord-023134-y665agnh 262 13 chamber chamber NN cord-023134-y665agnh 262 14 dimensions dimension NNS cord-023134-y665agnh 262 15 were be VBD cord-023134-y665agnh 262 16 measured measure VBN cord-023134-y665agnh 262 17 by by IN cord-023134-y665agnh 262 18 a a DT cord-023134-y665agnh 262 19 single single JJ cord-023134-y665agnh 262 20 blinded blinded JJ cord-023134-y665agnh 262 21 trained train VBN cord-023134-y665agnh 262 22 observer observer NN cord-023134-y665agnh 262 23 in in IN cord-023134-y665agnh 262 24 random random JJ cord-023134-y665agnh 262 25 order order NN cord-023134-y665agnh 262 26 , , , cord-023134-y665agnh 262 27 and and CC cord-023134-y665agnh 262 28 the the DT cord-023134-y665agnh 262 29 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 262 30 type type NN cord-023134-y665agnh 262 31 was be VBD cord-023134-y665agnh 262 32 classified classify VBN cord-023134-y665agnh 262 33 according accord VBG cord-023134-y665agnh 262 34 to to IN cord-023134-y665agnh 262 35 predefined predefined JJ cord-023134-y665agnh 262 36 criteria criterion NNS cord-023134-y665agnh 262 37 . . . cord-023134-y665agnh 263 1 Paired paired JJ cord-023134-y665agnh 263 2 comparisons comparison NNS cord-023134-y665agnh 263 3 were be VBD cord-023134-y665agnh 263 4 made make VBN cord-023134-y665agnh 263 5 using use VBG cord-023134-y665agnh 263 6 the the DT cord-023134-y665agnh 263 7 Wilcoxon Wilcoxon NNP cord-023134-y665agnh 263 8 signed sign VBN cord-023134-y665agnh 263 9 rank rank NN cord-023134-y665agnh 263 10 test test NN cord-023134-y665agnh 263 11 and and CC cord-023134-y665agnh 263 12 Fisher Fisher NNP cord-023134-y665agnh 263 13 's 's POS cord-023134-y665agnh 263 14 Exact Exact NNP cord-023134-y665agnh 263 15 test.63 test.63 NNP cord-023134-y665agnh 263 16 cats cat NNS cord-023134-y665agnh 263 17 met meet VBD cord-023134-y665agnh 263 18 the the DT cord-023134-y665agnh 263 19 inclusion inclusion NN cord-023134-y665agnh 263 20 criteria criterion NNS cord-023134-y665agnh 263 21 . . . cord-023134-y665agnh 264 1 Cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 264 2 type type NN cord-023134-y665agnh 264 3 at at IN cord-023134-y665agnh 264 4 entry entry NN cord-023134-y665agnh 264 5 consisted consist VBN cord-023134-y665agnh 264 6 of of IN cord-023134-y665agnh 264 7 hypertrophic hypertrophic JJ cord-023134-y665agnh 264 8 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 264 9 ( ( -LRB- cord-023134-y665agnh 264 10 HCM HCM NNP cord-023134-y665agnh 264 11 , , , cord-023134-y665agnh 264 12 n=60 n=60 JJ cord-023134-y665agnh 264 13 ) ) -RRB- cord-023134-y665agnh 264 14 , , , cord-023134-y665agnh 264 15 dilated dilated JJ cord-023134-y665agnh 264 16 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 264 17 ( ( -LRB- cord-023134-y665agnh 264 18 DCM DCM NNP cord-023134-y665agnh 264 19 , , , cord-023134-y665agnh 264 20 n=1 n=1 CD cord-023134-y665agnh 264 21 ) ) -RRB- cord-023134-y665agnh 264 22 , , , cord-023134-y665agnh 264 23 arrhythmogenic arrhythmogenic NNP cord-023134-y665agnh 264 24 right right JJ cord-023134-y665agnh 264 25 ventricular ventricular JJ cord-023134-y665agnh 264 26 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 264 27 ( ( -LRB- cord-023134-y665agnh 264 28 ARVC arvc NN cord-023134-y665agnh 264 29 , , , cord-023134-y665agnh 264 30 n=1 n=1 CD cord-023134-y665agnh 264 31 ) ) -RRB- cord-023134-y665agnh 264 32 and and CC cord-023134-y665agnh 264 33 1 1 CD cord-023134-y665agnh 264 34 normal normal JJ cord-023134-y665agnh 264 35 cat cat NN cord-023134-y665agnh 264 36 . . . cord-023134-y665agnh 265 1 Overall overall RB cord-023134-y665agnh 265 2 , , , cord-023134-y665agnh 265 3 median median NN cord-023134-y665agnh 265 4 left leave VBN cord-023134-y665agnh 265 5 ventricular ventricular JJ cord-023134-y665agnh 265 6 ( ( -LRB- cord-023134-y665agnh 265 7 LV LV NNP cord-023134-y665agnh 265 8 ) ) -RRB- cord-023134-y665agnh 266 1 diastolic diastolic JJ cord-023134-y665agnh 266 2 diameter diameter NN cord-023134-y665agnh 266 3 and and CC cord-023134-y665agnh 266 4 median median JJ cord-023134-y665agnh 266 5 long long JJ cord-023134-y665agnh 266 6 axis axis NN cord-023134-y665agnh 266 7 left leave VBN cord-023134-y665agnh 266 8 atrial atrial NN cord-023134-y665agnh 266 9 ( ( -LRB- cord-023134-y665agnh 266 10 LA LA NNP cord-023134-y665agnh 266 11 ) ) -RRB- cord-023134-y665agnh 266 12 diameter diameter NN cord-023134-y665agnh 266 13 both both CC cord-023134-y665agnh 266 14 increased increase VBN cord-023134-y665agnh 266 15 ( ( -LRB- cord-023134-y665agnh 266 16 p=0.007 p=0.007 NN cord-023134-y665agnh 266 17 , , , cord-023134-y665agnh 266 18 0.001 0.001 CD cord-023134-y665agnh 266 19 respectively respectively RB cord-023134-y665agnh 266 20 ) ) -RRB- cord-023134-y665agnh 266 21 whereas whereas IN cord-023134-y665agnh 266 22 LV LV NNP cord-023134-y665agnh 266 23 diastolic diastolic JJ cord-023134-y665agnh 266 24 wall wall NN cord-023134-y665agnh 266 25 thickness thickness NN cord-023134-y665agnh 266 26 and and CC cord-023134-y665agnh 266 27 LV LV NNP cord-023134-y665agnh 266 28 fractional fractional JJ cord-023134-y665agnh 266 29 shortening shortening NN cord-023134-y665agnh 266 30 did do VBD cord-023134-y665agnh 266 31 not not RB cord-023134-y665agnh 266 32 change change VB cord-023134-y665agnh 266 33 , , , cord-023134-y665agnh 266 34 but but CC cord-023134-y665agnh 266 35 changes change NNS cord-023134-y665agnh 266 36 in in IN cord-023134-y665agnh 266 37 dimensions dimension NNS cord-023134-y665agnh 266 38 of of IN cord-023134-y665agnh 266 39 > > SYM cord-023134-y665agnh 266 40 10 10 CD cord-023134-y665agnh 266 41 % % NN cord-023134-y665agnh 266 42 were be VBD cord-023134-y665agnh 266 43 seen see VBN cord-023134-y665agnh 266 44 in in IN cord-023134-y665agnh 266 45 both both DT cord-023134-y665agnh 266 46 directions direction NNS cord-023134-y665agnh 266 47 . . . cord-023134-y665agnh 267 1 Change change VB cord-023134-y665agnh 267 2 in in IN cord-023134-y665agnh 267 3 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 267 4 type type NN cord-023134-y665agnh 267 5 was be VBD cord-023134-y665agnh 267 6 documented document VBN cord-023134-y665agnh 267 7 in in IN cord-023134-y665agnh 267 8 3 3 CD cord-023134-y665agnh 267 9 cats cat NNS cord-023134-y665agnh 267 10 : : : cord-023134-y665agnh 267 11 HCM HCM NNP cord-023134-y665agnh 267 12 to to IN cord-023134-y665agnh 267 13 normal normal JJ cord-023134-y665agnh 267 14 ; ; : cord-023134-y665agnh 267 15 normal normal JJ cord-023134-y665agnh 267 16 to to IN cord-023134-y665agnh 267 17 HCM HCM NNP cord-023134-y665agnh 267 18 ; ; : cord-023134-y665agnh 267 19 HCM HCM NNP cord-023134-y665agnh 267 20 to to IN cord-023134-y665agnh 267 21 the the DT cord-023134-y665agnh 267 22 endomyocardial endomyocardial JJ cord-023134-y665agnh 267 23 form form NN cord-023134-y665agnh 267 24 of of IN cord-023134-y665agnh 267 25 restrictive restrictive JJ cord-023134-y665agnh 267 26 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 267 27 . . . cord-023134-y665agnh 268 1 The the DT cord-023134-y665agnh 268 2 inclusion inclusion NN cord-023134-y665agnh 268 3 criteria criterion NNS cord-023134-y665agnh 268 4 led lead VBD cord-023134-y665agnh 268 5 to to IN cord-023134-y665agnh 268 6 a a DT cord-023134-y665agnh 268 7 bias bias NN cord-023134-y665agnh 268 8 towards towards IN cord-023134-y665agnh 268 9 clinically clinically RB cord-023134-y665agnh 268 10 stable stable JJ cord-023134-y665agnh 268 11 cats cat NNS cord-023134-y665agnh 268 12 with with IN cord-023134-y665agnh 268 13 HCM HCM NNP cord-023134-y665agnh 268 14 . . . cord-023134-y665agnh 269 1 Despite despite IN cord-023134-y665agnh 269 2 this this DT cord-023134-y665agnh 269 3 , , , cord-023134-y665agnh 269 4 changes change NNS cord-023134-y665agnh 269 5 in in IN cord-023134-y665agnh 269 6 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 269 7 phenotype phenotype NN cord-023134-y665agnh 269 8 were be VBD cord-023134-y665agnh 269 9 observed observe VBN cord-023134-y665agnh 269 10 . . . cord-023134-y665agnh 270 1 Either either CC cord-023134-y665agnh 270 2 our -PRON- PRP$ cord-023134-y665agnh 270 3 criteria criterion NNS cord-023134-y665agnh 270 4 for for IN cord-023134-y665agnh 270 5 the the DT cord-023134-y665agnh 270 6 different different JJ cord-023134-y665agnh 270 7 feline feline JJ cord-023134-y665agnh 270 8 cardiomyopathies cardiomyopathy NNS cord-023134-y665agnh 270 9 should should MD cord-023134-y665agnh 270 10 be be VB cord-023134-y665agnh 270 11 defined define VBN cord-023134-y665agnh 270 12 more more RBR cord-023134-y665agnh 270 13 precisely precisely RB cord-023134-y665agnh 270 14 , , , cord-023134-y665agnh 270 15 or or CC cord-023134-y665agnh 270 16 phenotypic phenotypic JJ cord-023134-y665agnh 270 17 expression expression NN cord-023134-y665agnh 270 18 in in IN cord-023134-y665agnh 270 19 cats cat NNS cord-023134-y665agnh 270 20 with with IN cord-023134-y665agnh 270 21 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 270 22 changes change NNS cord-023134-y665agnh 270 23 over over IN cord-023134-y665agnh 270 24 time time NN cord-023134-y665agnh 270 25 . . . cord-023134-y665agnh 271 1 Transesophageal Transesophageal NNP cord-023134-y665agnh 271 2 echocardiography echocardiography NN cord-023134-y665agnh 271 3 ( ( -LRB- cord-023134-y665agnh 271 4 TEE tee NN cord-023134-y665agnh 271 5 ) ) -RRB- cord-023134-y665agnh 271 6 has have VBZ cord-023134-y665agnh 271 7 proven prove VBN cord-023134-y665agnh 271 8 useful useful JJ cord-023134-y665agnh 271 9 in in IN cord-023134-y665agnh 271 10 evaluating evaluate VBG cord-023134-y665agnh 271 11 patent patent NN cord-023134-y665agnh 271 12 ductus ductus NN cord-023134-y665agnh 271 13 arteriosus arteriosus NN cord-023134-y665agnh 271 14 ( ( -LRB- cord-023134-y665agnh 271 15 PDA PDA NNP cord-023134-y665agnh 271 16 ) ) -RRB- cord-023134-y665agnh 271 17 morphology morphology NN cord-023134-y665agnh 271 18 thereby thereby RB cord-023134-y665agnh 271 19 guiding guide VBG cord-023134-y665agnh 271 20 appropriate appropriate JJ cord-023134-y665agnh 271 21 device device NN cord-023134-y665agnh 271 22 selection selection NN cord-023134-y665agnh 271 23 . . . cord-023134-y665agnh 272 1 Additionally additionally RB cord-023134-y665agnh 272 2 , , , cord-023134-y665agnh 272 3 TEE TEE NNP cord-023134-y665agnh 272 4 , , , cord-023134-y665agnh 272 5 in in IN cord-023134-y665agnh 272 6 combination combination NN cord-023134-y665agnh 272 7 with with IN cord-023134-y665agnh 272 8 fluoroscopy fluoroscopy NN cord-023134-y665agnh 272 9 , , , cord-023134-y665agnh 272 10 has have VBZ cord-023134-y665agnh 272 11 been be VBN cord-023134-y665agnh 272 12 used use VBN cord-023134-y665agnh 272 13 to to TO cord-023134-y665agnh 272 14 guide guide VB cord-023134-y665agnh 272 15 the the DT cord-023134-y665agnh 272 16 transcatheter transcatheter NNP cord-023134-y665agnh 272 17 coil coil NN cord-023134-y665agnh 272 18 embolization embolization NN cord-023134-y665agnh 272 19 and and CC cord-023134-y665agnh 272 20 for for IN cord-023134-y665agnh 272 21 deployment deployment NN cord-023134-y665agnh 272 22 of of IN cord-023134-y665agnh 272 23 Amplatz Amplatz NNP cord-023134-y665agnh 272 24 Canine Canine NNP cord-023134-y665agnh 272 25 Ductal Ductal NNP cord-023134-y665agnh 272 26 Occluder Occluder NNP cord-023134-y665agnh 272 27 ( ( -LRB- cord-023134-y665agnh 272 28 ACDO ACDO NNP cord-023134-y665agnh 272 29 ) ) -RRB- cord-023134-y665agnh 272 30 in in IN cord-023134-y665agnh 272 31 dogs dog NNS cord-023134-y665agnh 272 32 . . . cord-023134-y665agnh 273 1 Recently recently RB cord-023134-y665agnh 273 2 , , , cord-023134-y665agnh 273 3 we -PRON- PRP cord-023134-y665agnh 273 4 described describe VBD cord-023134-y665agnh 273 5 the the DT cord-023134-y665agnh 273 6 use use NN cord-023134-y665agnh 273 7 of of IN cord-023134-y665agnh 273 8 transthoracic transthoracic NN cord-023134-y665agnh 273 9 echocardiography echocardiography NN cord-023134-y665agnh 273 10 ( ( -LRB- cord-023134-y665agnh 273 11 TTE TTE NNP cord-023134-y665agnh 273 12 ) ) -RRB- cord-023134-y665agnh 273 13 guidance guidance NN cord-023134-y665agnh 273 14 during during IN cord-023134-y665agnh 273 15 transcatether transcatether NN cord-023134-y665agnh 273 16 PDA PDA NNP cord-023134-y665agnh 273 17 occlusion occlusion NN cord-023134-y665agnh 273 18 with with IN cord-023134-y665agnh 273 19 ACDO ACDO NNP cord-023134-y665agnh 273 20 without without IN cord-023134-y665agnh 273 21 the the DT cord-023134-y665agnh 273 22 use use NN cord-023134-y665agnh 273 23 of of IN cord-023134-y665agnh 273 24 fluoroscopy fluoroscopy NN cord-023134-y665agnh 273 25 , , , cord-023134-y665agnh 273 26 but but CC cord-023134-y665agnh 273 27 observed observe VBD cord-023134-y665agnh 273 28 problems problem NNS cord-023134-y665agnh 273 29 of of IN cord-023134-y665agnh 273 30 deployment deployment NN cord-023134-y665agnh 273 31 in in IN cord-023134-y665agnh 273 32 patients patient NNS cord-023134-y665agnh 273 33 with with IN cord-023134-y665agnh 273 34 sub sub JJ cord-023134-y665agnh 273 35 - - JJ cord-023134-y665agnh 273 36 optimal optimal JJ cord-023134-y665agnh 273 37 acoustic acoustic JJ cord-023134-y665agnh 273 38 windows window NNS cord-023134-y665agnh 273 39 . . . cord-023134-y665agnh 274 1 However however RB cord-023134-y665agnh 274 2 , , , cord-023134-y665agnh 274 3 TEE TEE NNP cord-023134-y665agnh 274 4 , , , cord-023134-y665agnh 274 5 can can MD cord-023134-y665agnh 274 6 overcome overcome VB cord-023134-y665agnh 274 7 issues issue NNS cord-023134-y665agnh 274 8 of of IN cord-023134-y665agnh 274 9 suboptimal suboptimal JJ cord-023134-y665agnh 274 10 TTE TTE NNP cord-023134-y665agnh 274 11 acoustic acoustic JJ cord-023134-y665agnh 274 12 windows window NNS cord-023134-y665agnh 274 13 and and CC cord-023134-y665agnh 274 14 provides provide VBZ cord-023134-y665agnh 274 15 higher high JJR cord-023134-y665agnh 274 16 image image NN cord-023134-y665agnh 274 17 resolution resolution NN cord-023134-y665agnh 274 18 of of IN cord-023134-y665agnh 274 19 cardiac cardiac JJ cord-023134-y665agnh 274 20 and and CC cord-023134-y665agnh 274 21 vascular vascular JJ cord-023134-y665agnh 274 22 regions region NNS cord-023134-y665agnh 274 23 . . . cord-023134-y665agnh 275 1 Therefore therefore RB cord-023134-y665agnh 275 2 , , , cord-023134-y665agnh 275 3 we -PRON- PRP cord-023134-y665agnh 275 4 hypothesized hypothesize VBD cord-023134-y665agnh 275 5 that that IN cord-023134-y665agnh 275 6 TEE tee NN cord-023134-y665agnh 275 7 could could MD cord-023134-y665agnh 275 8 be be VB cord-023134-y665agnh 275 9 used use VBN cord-023134-y665agnh 275 10 to to TO cord-023134-y665agnh 275 11 successfully successfully RB cord-023134-y665agnh 275 12 visualize visualize VB cord-023134-y665agnh 275 13 the the DT cord-023134-y665agnh 275 14 vascular vascular JJ cord-023134-y665agnh 275 15 structures structure NNS cord-023134-y665agnh 275 16 and and CC cord-023134-y665agnh 275 17 interventional interventional JJ cord-023134-y665agnh 275 18 devices device NNS cord-023134-y665agnh 275 19 to to TO cord-023134-y665agnh 275 20 safely safely RB cord-023134-y665agnh 275 21 perform perform VB cord-023134-y665agnh 275 22 PDA PDA NNP cord-023134-y665agnh 275 23 occlusion occlusion NN cord-023134-y665agnh 275 24 with with IN cord-023134-y665agnh 275 25 ACDO ACDO NNP cord-023134-y665agnh 275 26 without without IN cord-023134-y665agnh 275 27 requiring require VBG cord-023134-y665agnh 275 28 fluoroscopy fluoroscopy NN cord-023134-y665agnh 275 29 . . . cord-023134-y665agnh 276 1 We -PRON- PRP cord-023134-y665agnh 276 2 recruited recruit VBD cord-023134-y665agnh 276 3 5 5 CD cord-023134-y665agnh 276 4 dogs dog NNS cord-023134-y665agnh 276 5 with with IN cord-023134-y665agnh 276 6 patent patent NN cord-023134-y665agnh 276 7 ductus ductus NN cord-023134-y665agnh 276 8 arteriosus arteriosus NN cord-023134-y665agnh 276 9 ( ( -LRB- cord-023134-y665agnh 276 10 PDA PDA NNP cord-023134-y665agnh 276 11 ) ) -RRB- cord-023134-y665agnh 276 12 for for IN cord-023134-y665agnh 276 13 TEE tee NN cord-023134-y665agnh 276 14 - - HYPH cord-023134-y665agnh 276 15 guided guide VBN cord-023134-y665agnh 276 16 percutaneous percutaneous JJ cord-023134-y665agnh 276 17 ductal ductal JJ cord-023134-y665agnh 276 18 occlusion occlusion NN cord-023134-y665agnh 276 19 with with IN cord-023134-y665agnh 276 20 an an DT cord-023134-y665agnh 276 21 ACDO ACDO NNP cord-023134-y665agnh 276 22 . . . cord-023134-y665agnh 277 1 Dogs dog NNS cord-023134-y665agnh 277 2 were be VBD cord-023134-y665agnh 277 3 anesthetized anesthetize VBN cord-023134-y665agnh 277 4 , , , cord-023134-y665agnh 277 5 positioned position VBN cord-023134-y665agnh 277 6 in in IN cord-023134-y665agnh 277 7 right right JJ cord-023134-y665agnh 277 8 lateral lateral JJ cord-023134-y665agnh 277 9 recumbency recumbency NN cord-023134-y665agnh 277 10 and and CC cord-023134-y665agnh 277 11 the the DT cord-023134-y665agnh 277 12 right right JJ cord-023134-y665agnh 277 13 femoral femoral JJ cord-023134-y665agnh 277 14 artery artery NN cord-023134-y665agnh 277 15 was be VBD cord-023134-y665agnh 277 16 accessed access VBN cord-023134-y665agnh 277 17 percutaneously percutaneously NNP cord-023134-y665agnh 277 18 ( ( -LRB- cord-023134-y665agnh 277 19 modified modify VBN cord-023134-y665agnh 277 20 Seldinger Seldinger NNP cord-023134-y665agnh 277 21 technique technique NN cord-023134-y665agnh 277 22 ) ) -RRB- cord-023134-y665agnh 277 23 . . . cord-023134-y665agnh 278 1 The the DT cord-023134-y665agnh 278 2 TEE tee NN cord-023134-y665agnh 278 3 probe probe NN cord-023134-y665agnh 278 4 was be VBD cord-023134-y665agnh 278 5 advanced advanced JJ cord-023134-y665agnh 278 6 to to IN cord-023134-y665agnh 278 7 a a DT cord-023134-y665agnh 278 8 midesophageal midesophageal JJ cord-023134-y665agnh 278 9 position position NN cord-023134-y665agnh 278 10 with with IN cord-023134-y665agnh 278 11 minimal minimal JJ cord-023134-y665agnh 278 12 force force NN cord-023134-y665agnh 278 13 to to TO cord-023134-y665agnh 278 14 obtain obtain VB cord-023134-y665agnh 278 15 a a DT cord-023134-y665agnh 278 16 long long JJ cord-023134-y665agnh 278 17 axis axis NN cord-023134-y665agnh 278 18 4-chamber 4-chamber CD cord-023134-y665agnh 278 19 view view NN cord-023134-y665agnh 278 20 ( ( -LRB- cord-023134-y665agnh 278 21 transverse transverse JJ cord-023134-y665agnh 278 22 plane plane NN cord-023134-y665agnh 278 23 ) ) -RRB- cord-023134-y665agnh 278 24 . . . cord-023134-y665agnh 279 1 The the DT cord-023134-y665agnh 279 2 probe probe NN cord-023134-y665agnh 279 3 was be VBD cord-023134-y665agnh 279 4 then then RB cord-023134-y665agnh 279 5 retroflexed retroflex VBN cord-023134-y665agnh 279 6 and and CC cord-023134-y665agnh 279 7 withdrawn withdraw VBN cord-023134-y665agnh 279 8 to to IN cord-023134-y665agnh 279 9 a a DT cord-023134-y665agnh 279 10 cranial cranial JJ cord-023134-y665agnh 279 11 esophageal esophageal JJ cord-023134-y665agnh 279 12 position position NN cord-023134-y665agnh 279 13 until until IN cord-023134-y665agnh 279 14 a a DT cord-023134-y665agnh 279 15 cross cross NN cord-023134-y665agnh 279 16 section section NN cord-023134-y665agnh 279 17 of of IN cord-023134-y665agnh 279 18 the the DT cord-023134-y665agnh 279 19 descending descend VBG cord-023134-y665agnh 279 20 aorta aorta NN cord-023134-y665agnh 279 21 was be VBD cord-023134-y665agnh 279 22 seen see VBN cord-023134-y665agnh 279 23 . . . cord-023134-y665agnh 280 1 To to TO cord-023134-y665agnh 280 2 visualize visualize VB cord-023134-y665agnh 280 3 PDA PDA NNP cord-023134-y665agnh 280 4 to to IN cord-023134-y665agnh 280 5 the the DT cord-023134-y665agnh 280 6 probe probe NN cord-023134-y665agnh 280 7 was be VBD cord-023134-y665agnh 280 8 slightly slightly RB cord-023134-y665agnh 280 9 straightened straighten VBN cord-023134-y665agnh 280 10 and and CC cord-023134-y665agnh 280 11 turned turn VBD cord-023134-y665agnh 280 12 counterclockwise counterclockwise RB cord-023134-y665agnh 280 13 , , , cord-023134-y665agnh 280 14 and and CC cord-023134-y665agnh 280 15 the the DT cord-023134-y665agnh 280 16 ultrasonic ultrasonic JJ cord-023134-y665agnh 280 17 beam beam NN cord-023134-y665agnh 280 18 was be VBD cord-023134-y665agnh 280 19 oriented orient VBN cord-023134-y665agnh 280 20 between between IN cord-023134-y665agnh 280 21 60 60 CD cord-023134-y665agnh 280 22 and and CC cord-023134-y665agnh 280 23 120 120 CD cord-023134-y665agnh 280 24 degrees degree NNS cord-023134-y665agnh 280 25 . . . cord-023134-y665agnh 281 1 In in IN cord-023134-y665agnh 281 2 all all DT cord-023134-y665agnh 281 3 dogs dog NNS cord-023134-y665agnh 281 4 , , , cord-023134-y665agnh 281 5 the the DT cord-023134-y665agnh 281 6 guide guide NN cord-023134-y665agnh 281 7 wire wire NN cord-023134-y665agnh 281 8 and and CC cord-023134-y665agnh 281 9 a a DT cord-023134-y665agnh 281 10 long long JJ cord-023134-y665agnh 281 11 introducer introducer NN cord-023134-y665agnh 281 12 - - HYPH cord-023134-y665agnh 281 13 sheath sheath NN cord-023134-y665agnh 281 14 were be VBD cord-023134-y665agnh 281 15 guided guide VBN cord-023134-y665agnh 281 16 from from IN cord-023134-y665agnh 281 17 the the DT cord-023134-y665agnh 281 18 aorta aorta NN cord-023134-y665agnh 281 19 through through IN cord-023134-y665agnh 281 20 the the DT cord-023134-y665agnh 281 21 PDA PDA NNP cord-023134-y665agnh 281 22 into into IN cord-023134-y665agnh 281 23 the the DT cord-023134-y665agnh 281 24 main main JJ cord-023134-y665agnh 281 25 pulmonary pulmonary JJ cord-023134-y665agnh 281 26 artery artery NN cord-023134-y665agnh 281 27 by by IN cord-023134-y665agnh 281 28 TEE tee NN cord-023134-y665agnh 281 29 monitoring monitoring NN cord-023134-y665agnh 281 30 . . . cord-023134-y665agnh 282 1 The the DT cord-023134-y665agnh 282 2 ACDO ACDO NNP cord-023134-y665agnh 282 3 was be VBD cord-023134-y665agnh 282 4 advanced advance VBN cord-023134-y665agnh 282 5 through through IN cord-023134-y665agnh 282 6 the the DT cord-023134-y665agnh 282 7 introducer introducer NN cord-023134-y665agnh 282 8 - - HYPH cord-023134-y665agnh 282 9 sheath sheath NN cord-023134-y665agnh 282 10 until until IN cord-023134-y665agnh 282 11 the the DT cord-023134-y665agnh 282 12 flat flat JJ cord-023134-y665agnh 282 13 distal distal JJ cord-023134-y665agnh 282 14 disk disk NN cord-023134-y665agnh 282 15 was be VBD cord-023134-y665agnh 282 16 visualized visualize VBN cord-023134-y665agnh 282 17 within within IN cord-023134-y665agnh 282 18 the the DT cord-023134-y665agnh 282 19 main main JJ cord-023134-y665agnh 282 20 pulmonary pulmonary JJ cord-023134-y665agnh 282 21 artery artery NN cord-023134-y665agnh 282 22 by by IN cord-023134-y665agnh 282 23 TEE tee NN cord-023134-y665agnh 282 24 monitoring monitoring NN cord-023134-y665agnh 282 25 . . . cord-023134-y665agnh 283 1 The the DT cord-023134-y665agnh 283 2 distal distal JJ cord-023134-y665agnh 283 3 disk disk NN cord-023134-y665agnh 283 4 was be VBD cord-023134-y665agnh 283 5 positioned position VBN cord-023134-y665agnh 283 6 against against IN cord-023134-y665agnh 283 7 the the DT cord-023134-y665agnh 283 8 pulmonic pulmonic JJ cord-023134-y665agnh 283 9 ostium ostium NN cord-023134-y665agnh 283 10 and and CC cord-023134-y665agnh 283 11 the the DT cord-023134-y665agnh 283 12 coupled coupled JJ cord-023134-y665agnh 283 13 proximal proximal JJ cord-023134-y665agnh 283 14 disk disk NN cord-023134-y665agnh 283 15 was be VBD cord-023134-y665agnh 283 16 deployed deploy VBN cord-023134-y665agnh 283 17 within within IN cord-023134-y665agnh 283 18 the the DT cord-023134-y665agnh 283 19 ductal ductal JJ cord-023134-y665agnh 283 20 ampulla ampulla NN cord-023134-y665agnh 283 21 while while IN cord-023134-y665agnh 283 22 being be VBG cord-023134-y665agnh 283 23 monitored monitor VBN cord-023134-y665agnh 283 24 by by IN cord-023134-y665agnh 283 25 TEE tee NN cord-023134-y665agnh 283 26 visualization visualization NN cord-023134-y665agnh 283 27 . . . cord-023134-y665agnh 284 1 The the DT cord-023134-y665agnh 284 2 guide guide NN cord-023134-y665agnh 284 3 wires wire NNS cord-023134-y665agnh 284 4 , , , cord-023134-y665agnh 284 5 long long JJ cord-023134-y665agnh 284 6 introducer introducer NN cord-023134-y665agnh 284 7 - - HYPH cord-023134-y665agnh 284 8 sheath sheath NN cord-023134-y665agnh 284 9 and and CC cord-023134-y665agnh 284 10 ACDO ACDO NNP cord-023134-y665agnh 284 11 appeared appear VBD cord-023134-y665agnh 284 12 hyperechoic hyperechoic NN cord-023134-y665agnh 284 13 on on IN cord-023134-y665agnh 284 14 TEE tee NN cord-023134-y665agnh 284 15 images image NNS cord-023134-y665agnh 284 16 and and CC cord-023134-y665agnh 284 17 TEE tee NN cord-023134-y665agnh 284 18 guidance guidance NN cord-023134-y665agnh 284 19 provided provide VBD cord-023134-y665agnh 284 20 images image NNS cord-023134-y665agnh 284 21 of of IN cord-023134-y665agnh 284 22 sufficient sufficient JJ cord-023134-y665agnh 284 23 quality quality NN cord-023134-y665agnh 284 24 to to TO cord-023134-y665agnh 284 25 clearly clearly RB cord-023134-y665agnh 284 26 monitor monitor VB cord-023134-y665agnh 284 27 the the DT cord-023134-y665agnh 284 28 procedures procedure NNS cord-023134-y665agnh 284 29 in in IN cord-023134-y665agnh 284 30 real real JJ cord-023134-y665agnh 284 31 - - HYPH cord-023134-y665agnh 284 32 time time NN cord-023134-y665agnh 284 33 . . . cord-023134-y665agnh 285 1 Real real JJ cord-023134-y665agnh 285 2 - - HYPH cord-023134-y665agnh 285 3 time time NN cord-023134-y665agnh 285 4 monitoring monitoring NN cord-023134-y665agnh 285 5 also also RB cord-023134-y665agnh 285 6 allowed allow VBN cord-023134-y665agnh 285 7 for for IN cord-023134-y665agnh 285 8 immediate immediate JJ cord-023134-y665agnh 285 9 corrections correction NNS cord-023134-y665agnh 285 10 to to TO cord-023134-y665agnh 285 11 guide guide VB cord-023134-y665agnh 285 12 wire wire NN cord-023134-y665agnh 285 13 , , , cord-023134-y665agnh 285 14 catheter catheter NN cord-023134-y665agnh 285 15 or or CC cord-023134-y665agnh 285 16 device device NN cord-023134-y665agnh 285 17 positioning positioning NN cord-023134-y665agnh 285 18 . . . cord-023134-y665agnh 286 1 The the DT cord-023134-y665agnh 286 2 procedures procedure NNS cord-023134-y665agnh 286 3 were be VBD cord-023134-y665agnh 286 4 successful successful JJ cord-023134-y665agnh 286 5 and and CC cord-023134-y665agnh 286 6 without without IN cord-023134-y665agnh 286 7 complications complication NNS cord-023134-y665agnh 286 8 in in IN cord-023134-y665agnh 286 9 all all DT cord-023134-y665agnh 286 10 patients patient NNS cord-023134-y665agnh 286 11 . . . cord-023134-y665agnh 287 1 We -PRON- PRP cord-023134-y665agnh 287 2 have have VBP cord-023134-y665agnh 287 3 demonstrated demonstrate VBN cord-023134-y665agnh 287 4 that that IN cord-023134-y665agnh 287 5 TEE tee NN cord-023134-y665agnh 287 6 monitoring monitoring NN cord-023134-y665agnh 287 7 , , , cord-023134-y665agnh 287 8 like like IN cord-023134-y665agnh 287 9 TTE TTE NNP cord-023134-y665agnh 287 10 monitoring monitoring NN cord-023134-y665agnh 287 11 , , , cord-023134-y665agnh 287 12 can can MD cord-023134-y665agnh 287 13 guide guide VB cord-023134-y665agnh 287 14 every every DT cord-023134-y665agnh 287 15 step step NN cord-023134-y665agnh 287 16 of of IN cord-023134-y665agnh 287 17 transcatheter transcatheter NNP cord-023134-y665agnh 287 18 ACDO ACDO NNP cord-023134-y665agnh 287 19 embolization embolization NN cord-023134-y665agnh 287 20 procedures procedure NNS cord-023134-y665agnh 287 21 without without IN cord-023134-y665agnh 287 22 requiring require VBG cord-023134-y665agnh 287 23 fluoroscopy fluoroscopy NN cord-023134-y665agnh 287 24 , , , cord-023134-y665agnh 287 25 thereby thereby RB cord-023134-y665agnh 287 26 avoiding avoid VBG cord-023134-y665agnh 287 27 radiation radiation NN cord-023134-y665agnh 287 28 exposure exposure NN cord-023134-y665agnh 287 29 , , , cord-023134-y665agnh 287 30 and and CC cord-023134-y665agnh 287 31 provides provide VBZ cord-023134-y665agnh 287 32 an an DT cord-023134-y665agnh 287 33 alternative alternative NN cord-023134-y665agnh 287 34 to to IN cord-023134-y665agnh 287 35 TTE TTE NNP cord-023134-y665agnh 287 36 - - HYPH cord-023134-y665agnh 287 37 based base VBN cord-023134-y665agnh 287 38 guidance guidance NN cord-023134-y665agnh 287 39 , , , cord-023134-y665agnh 287 40 especially especially RB cord-023134-y665agnh 287 41 when when WRB cord-023134-y665agnh 287 42 TTE TTE NNP cord-023134-y665agnh 287 43 visualization visualization NN cord-023134-y665agnh 287 44 of of IN cord-023134-y665agnh 287 45 the the DT cord-023134-y665agnh 287 46 PDA PDA NNP cord-023134-y665agnh 287 47 is be VBZ cord-023134-y665agnh 287 48 insufficient insufficient JJ cord-023134-y665agnh 287 49 for for IN cord-023134-y665agnh 287 50 safe safe JJ cord-023134-y665agnh 287 51 and and CC cord-023134-y665agnh 287 52 timely timely JJ cord-023134-y665agnh 287 53 ACDO ACDO NNP cord-023134-y665agnh 287 54 deployment deployment NN cord-023134-y665agnh 287 55 . . . cord-023134-y665agnh 288 1 Right right JJ cord-023134-y665agnh 288 2 ventricular ventricular NN cord-023134-y665agnh 288 3 ( ( -LRB- cord-023134-y665agnh 288 4 RV rv NN cord-023134-y665agnh 288 5 ) ) -RRB- cord-023134-y665agnh 288 6 dysfunction dysfunction NN cord-023134-y665agnh 288 7 occurs occur VBZ cord-023134-y665agnh 288 8 in in IN cord-023134-y665agnh 288 9 human human JJ cord-023134-y665agnh 288 10 patients patient NNS cord-023134-y665agnh 288 11 with with IN cord-023134-y665agnh 288 12 left left JJ cord-023134-y665agnh 288 13 - - HYPH cord-023134-y665agnh 288 14 sided sided JJ cord-023134-y665agnh 288 15 cardiac cardiac JJ cord-023134-y665agnh 288 16 disorders disorder NNS cord-023134-y665agnh 288 17 because because IN cord-023134-y665agnh 288 18 of of IN cord-023134-y665agnh 288 19 the the DT cord-023134-y665agnh 288 20 mechanism mechanism NN cord-023134-y665agnh 288 21 of of IN cord-023134-y665agnh 288 22 ventricular ventricular JJ cord-023134-y665agnh 288 23 interdependence interdependence NN cord-023134-y665agnh 288 24 . . . cord-023134-y665agnh 289 1 Doppler Doppler NNP cord-023134-y665agnh 289 2 echocardiographic echocardiographic JJ cord-023134-y665agnh 289 3 indices index NNS cord-023134-y665agnh 289 4 of of IN cord-023134-y665agnh 289 5 diastolic diastolic JJ cord-023134-y665agnh 289 6 function function NN cord-023134-y665agnh 289 7 of of IN cord-023134-y665agnh 289 8 the the DT cord-023134-y665agnh 289 9 right right JJ cord-023134-y665agnh 289 10 ventricle ventricle NN cord-023134-y665agnh 289 11 are be VBP cord-023134-y665agnh 289 12 good good JJ cord-023134-y665agnh 289 13 prognostic prognostic JJ cord-023134-y665agnh 289 14 markers marker NNS cord-023134-y665agnh 289 15 during during IN cord-023134-y665agnh 289 16 left left JJ cord-023134-y665agnh 289 17 ventricular ventricular JJ cord-023134-y665agnh 289 18 ( ( -LRB- cord-023134-y665agnh 289 19 LV LV NNP cord-023134-y665agnh 289 20 ) ) -RRB- cord-023134-y665agnh 289 21 failure failure NN cord-023134-y665agnh 289 22 secondary secondary JJ cord-023134-y665agnh 289 23 to to IN cord-023134-y665agnh 289 24 ischemic ischemic JJ cord-023134-y665agnh 289 25 and and CC cord-023134-y665agnh 289 26 dilated dilated JJ cord-023134-y665agnh 289 27 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 289 28 . . . cord-023134-y665agnh 290 1 The the DT cord-023134-y665agnh 290 2 aims aim NNS cord-023134-y665agnh 290 3 of of IN cord-023134-y665agnh 290 4 the the DT cord-023134-y665agnh 290 5 present present JJ cord-023134-y665agnh 290 6 study study NN cord-023134-y665agnh 290 7 were be VBD cord-023134-y665agnh 290 8 : : : cord-023134-y665agnh 290 9 to to TO cord-023134-y665agnh 290 10 assess assess VB cord-023134-y665agnh 290 11 LV LV NNP cord-023134-y665agnh 290 12 and and CC cord-023134-y665agnh 290 13 RV RV NNP cord-023134-y665agnh 290 14 diastolic diastolic JJ cord-023134-y665agnh 290 15 function function NN cord-023134-y665agnh 290 16 by by IN cord-023134-y665agnh 290 17 conventional conventional JJ cord-023134-y665agnh 290 18 Doppler Doppler NNP cord-023134-y665agnh 290 19 and and CC cord-023134-y665agnh 290 20 pulsed pulse VBN cord-023134-y665agnh 290 21 - - HYPH cord-023134-y665agnh 290 22 wave wave NN cord-023134-y665agnh 290 23 tissue tissue NN cord-023134-y665agnh 290 24 Doppler doppler NN cord-023134-y665agnh 290 25 imaging imaging NN cord-023134-y665agnh 290 26 ( ( -LRB- cord-023134-y665agnh 290 27 PW pw NN cord-023134-y665agnh 290 28 - - HYPH cord-023134-y665agnh 290 29 TDI TDI NNP cord-023134-y665agnh 290 30 ) ) -RRB- cord-023134-y665agnh 290 31 in in IN cord-023134-y665agnh 290 32 dogs dog NNS cord-023134-y665agnh 290 33 with with IN cord-023134-y665agnh 290 34 mitral mitral JJ cord-023134-y665agnh 290 35 valve valve NN cord-023134-y665agnh 290 36 disease disease NN cord-023134-y665agnh 290 37 ( ( -LRB- cord-023134-y665agnh 290 38 MVD MVD NNP cord-023134-y665agnh 290 39 ) ) -RRB- cord-023134-y665agnh 290 40 , , , cord-023134-y665agnh 290 41 with with IN cord-023134-y665agnh 290 42 or or CC cord-023134-y665agnh 290 43 without without IN cord-023134-y665agnh 290 44 pulmonary pulmonary JJ cord-023134-y665agnh 290 45 hypertension hypertension NN cord-023134-y665agnh 290 46 ( ( -LRB- cord-023134-y665agnh 290 47 PH PH NNP cord-023134-y665agnh 290 48 ) ) -RRB- cord-023134-y665agnh 290 49 ; ; : cord-023134-y665agnh 290 50 to to TO cord-023134-y665agnh 290 51 test test VB cord-023134-y665agnh 290 52 if if IN cord-023134-y665agnh 290 53 echocardiographic echocardiographic JJ cord-023134-y665agnh 290 54 parameters parameter NNS cord-023134-y665agnh 290 55 of of IN cord-023134-y665agnh 290 56 LV LV NNP cord-023134-y665agnh 290 57 and and CC cord-023134-y665agnh 290 58 RV RV NNP cord-023134-y665agnh 290 59 diastolic diastolic JJ cord-023134-y665agnh 290 60 dysfunction dysfunction NN cord-023134-y665agnh 290 61 correlate correlate VBP cord-023134-y665agnh 290 62 to to IN cord-023134-y665agnh 290 63 the the DT cord-023134-y665agnh 290 64 Doppler Doppler NNP cord-023134-y665agnh 290 65 - - HYPH cord-023134-y665agnh 290 66 estimated estimate VBN cord-023134-y665agnh 290 67 pulmonary pulmonary JJ cord-023134-y665agnh 290 68 artery artery NN cord-023134-y665agnh 290 69 systolic systolic JJ cord-023134-y665agnh 290 70 pressure pressure NN cord-023134-y665agnh 290 71 ( ( -LRB- cord-023134-y665agnh 290 72 PASP).114 PASP).114 NNP cord-023134-y665agnh 290 73 dogs dog NNS cord-023134-y665agnh 290 74 were be VBD cord-023134-y665agnh 290 75 prospectively prospectively RB cord-023134-y665agnh 290 76 evaluated evaluate VBN cord-023134-y665agnh 290 77 , , , cord-023134-y665agnh 290 78 including include VBG cord-023134-y665agnh 290 79 86 86 CD cord-023134-y665agnh 290 80 dogs dog NNS cord-023134-y665agnh 290 81 with with IN cord-023134-y665agnh 290 82 MVD MVD NNP cord-023134-y665agnh 290 83 . . . cord-023134-y665agnh 291 1 For for IN cord-023134-y665agnh 291 2 each each DT cord-023134-y665agnh 291 3 dog dog NN cord-023134-y665agnh 291 4 , , , cord-023134-y665agnh 291 5 a a DT cord-023134-y665agnh 291 6 complete complete JJ cord-023134-y665agnh 291 7 echocardiographic echocardiographic JJ cord-023134-y665agnh 291 8 evaluation evaluation NN cord-023134-y665agnh 291 9 was be VBD cord-023134-y665agnh 291 10 carried carry VBN cord-023134-y665agnh 291 11 out out RP cord-023134-y665agnh 291 12 . . . cord-023134-y665agnh 292 1 Dogs dog NNS cord-023134-y665agnh 292 2 with with IN cord-023134-y665agnh 292 3 MVD MVD NNP cord-023134-y665agnh 292 4 were be VBD cord-023134-y665agnh 292 5 divided divide VBN cord-023134-y665agnh 292 6 in in IN cord-023134-y665agnh 292 7 3 3 CD cord-023134-y665agnh 292 8 groups group NNS cord-023134-y665agnh 292 9 according accord VBG cord-023134-y665agnh 292 10 to to IN cord-023134-y665agnh 292 11 the the DT cord-023134-y665agnh 292 12 ACVIM ACVIM NNP cord-023134-y665agnh 292 13 classification classification NN cord-023134-y665agnh 292 14 of of IN cord-023134-y665agnh 292 15 heart heart NN cord-023134-y665agnh 292 16 failure failure NN cord-023134-y665agnh 292 17 . . . cord-023134-y665agnh 293 1 Using use VBG cord-023134-y665agnh 293 2 the the DT cord-023134-y665agnh 293 3 cut cut VB cord-023134-y665agnh 293 4 - - HYPH cord-023134-y665agnh 293 5 off off RP cord-023134-y665agnh 293 6 value value NN cord-023134-y665agnh 293 7 of of IN cord-023134-y665agnh 293 8 tricuspid tricuspid JJ cord-023134-y665agnh 293 9 regurgitation regurgitation NN cord-023134-y665agnh 293 10 ( ( -LRB- cord-023134-y665agnh 293 11 TR TR NNP cord-023134-y665agnh 293 12 ) ) -RRB- cord-023134-y665agnh 293 13 peak peak NN cord-023134-y665agnh 293 14 velocity velocity NN cord-023134-y665agnh 293 15 of of IN cord-023134-y665agnh 293 16 2.8 2.8 CD cord-023134-y665agnh 293 17 m m NN cord-023134-y665agnh 293 18 / / SYM cord-023134-y665agnh 293 19 s s NN cord-023134-y665agnh 293 20 , , , cord-023134-y665agnh 293 21 presence presence NN cord-023134-y665agnh 293 22 or or CC cord-023134-y665agnh 293 23 absence absence NN cord-023134-y665agnh 293 24 of of IN cord-023134-y665agnh 293 25 PH PH NNP cord-023134-y665agnh 293 26 was be VBD cord-023134-y665agnh 293 27 considered consider VBN cord-023134-y665agnh 293 28 , , , cord-023134-y665agnh 293 29 Standard standard JJ cord-023134-y665agnh 293 30 echocardiographic echocardiographic JJ cord-023134-y665agnh 293 31 and and CC cord-023134-y665agnh 293 32 mitral mitral JJ cord-023134-y665agnh 293 33 and and CC cord-023134-y665agnh 293 34 tricuspid tricuspid JJ cord-023134-y665agnh 293 35 Doppler doppler NN cord-023134-y665agnh 293 36 parameters parameter NNS cord-023134-y665agnh 293 37 ( ( -LRB- cord-023134-y665agnh 293 38 E e NN cord-023134-y665agnh 293 39 wave wave NN cord-023134-y665agnh 293 40 and and CC cord-023134-y665agnh 293 41 A a DT cord-023134-y665agnh 293 42 wave wave NN cord-023134-y665agnh 293 43 ) ) -RRB- cord-023134-y665agnh 293 44 , , , cord-023134-y665agnh 293 45 and and CC cord-023134-y665agnh 293 46 PW pw NN cord-023134-y665agnh 293 47 - - HYPH cord-023134-y665agnh 293 48 TDI tdi NN cord-023134-y665agnh 293 49 parameters parameter NNS cord-023134-y665agnh 293 50 ( ( -LRB- cord-023134-y665agnh 293 51 systolic systolic JJ cord-023134-y665agnh 293 52 wave wave NN cord-023134-y665agnh 293 53 , , , cord-023134-y665agnh 293 54 Sa Sa NNP cord-023134-y665agnh 293 55 ; ; : cord-023134-y665agnh 293 56 early early JJ cord-023134-y665agnh 293 57 diastolic diastolic JJ cord-023134-y665agnh 293 58 wave wave NN cord-023134-y665agnh 293 59 , , , cord-023134-y665agnh 293 60 e e NN cord-023134-y665agnh 293 61 ' ' '' cord-023134-y665agnh 293 62 ; ; : cord-023134-y665agnh 293 63 late late JJ cord-023134-y665agnh 293 64 diastolic diastolic JJ cord-023134-y665agnh 293 65 wave wave NN cord-023134-y665agnh 293 66 , , , cord-023134-y665agnh 293 67 a a DT cord-023134-y665agnh 293 68 ' ' '' cord-023134-y665agnh 293 69 ; ; : cord-023134-y665agnh 293 70 e'/a e'/a NNP cord-023134-y665agnh 293 71 ' ' '' cord-023134-y665agnh 293 72 ratio ratio NN cord-023134-y665agnh 293 73 ; ; : cord-023134-y665agnh 293 74 E e NN cord-023134-y665agnh 293 75 / / SYM cord-023134-y665agnh 293 76 e e NN cord-023134-y665agnh 293 77 ' ' '' cord-023134-y665agnh 293 78 ratio ratio NN cord-023134-y665agnh 293 79 ) ) -RRB- cord-023134-y665agnh 293 80 for for IN cord-023134-y665agnh 293 81 lateral lateral JJ cord-023134-y665agnh 293 82 and and CC cord-023134-y665agnh 293 83 septal septal JJ cord-023134-y665agnh 293 84 mitral mitral JJ cord-023134-y665agnh 293 85 annulus annulus NN cord-023134-y665agnh 293 86 , , , cord-023134-y665agnh 293 87 and and CC cord-023134-y665agnh 293 88 lateral lateral JJ cord-023134-y665agnh 293 89 tricuspid tricuspid NN cord-023134-y665agnh 293 90 annulus annulus NN cord-023134-y665agnh 293 91 were be VBD cord-023134-y665agnh 293 92 measured measure VBN cord-023134-y665agnh 293 93 . . . cord-023134-y665agnh 294 1 The the DT cord-023134-y665agnh 294 2 echocardiographic echocardiographic JJ cord-023134-y665agnh 294 3 data datum NNS cord-023134-y665agnh 294 4 were be VBD cord-023134-y665agnh 294 5 compared compare VBN cord-023134-y665agnh 294 6 by by IN cord-023134-y665agnh 294 7 use use NN cord-023134-y665agnh 294 8 of of IN cord-023134-y665agnh 294 9 ANOVA ANOVA NNP cord-023134-y665agnh 294 10 and and CC cord-023134-y665agnh 294 11 multiple multiple JJ cord-023134-y665agnh 294 12 contrast contrast NN cord-023134-y665agnh 294 13 t t NN cord-023134-y665agnh 294 14 - - HYPH cord-023134-y665agnh 294 15 test test NN cord-023134-y665agnh 294 16 with with IN cord-023134-y665agnh 294 17 Bonferroni Bonferroni NNP cord-023134-y665agnh 294 18 correction correction NN cord-023134-y665agnh 294 19 . . . cord-023134-y665agnh 295 1 The the DT cord-023134-y665agnh 295 2 relationship relationship NN cord-023134-y665agnh 295 3 between between IN cord-023134-y665agnh 295 4 left left JJ cord-023134-y665agnh 295 5 - - HYPH cord-023134-y665agnh 295 6 sided sided JJ cord-023134-y665agnh 295 7 echocar echocar JJ cord-023134-y665agnh 295 8 - - HYPH cord-023134-y665agnh 295 9 diographic diographic JJ cord-023134-y665agnh 295 10 parameters parameter NNS cord-023134-y665agnh 295 11 and and CC cord-023134-y665agnh 295 12 RV rv NN cord-023134-y665agnh 295 13 diastolic diastolic JJ cord-023134-y665agnh 295 14 parameters parameter NNS cord-023134-y665agnh 295 15 was be VBD cord-023134-y665agnh 295 16 examined examine VBN cord-023134-y665agnh 295 17 by by IN cord-023134-y665agnh 295 18 correlation correlation NN cord-023134-y665agnh 295 19 analysis analysis NN cord-023134-y665agnh 295 20 . . . cord-023134-y665agnh 296 1 The the DT cord-023134-y665agnh 296 2 correlation correlation NN cord-023134-y665agnh 296 3 of of IN cord-023134-y665agnh 296 4 PASP PASP NNP cord-023134-y665agnh 296 5 with with IN cord-023134-y665agnh 296 6 LV LV NNP cord-023134-y665agnh 296 7 and and CC cord-023134-y665agnh 296 8 RV RV NNP cord-023134-y665agnh 296 9 diastolic diastolic JJ cord-023134-y665agnh 296 10 parameters parameter NNS cord-023134-y665agnh 296 11 was be VBD cord-023134-y665agnh 296 12 examined examine VBN cord-023134-y665agnh 296 13 by by IN cord-023134-y665agnh 296 14 multiple multiple JJ cord-023134-y665agnh 296 15 linear linear JJ cord-023134-y665agnh 296 16 regression regression NN cord-023134-y665agnh 296 17 . . . cord-023134-y665agnh 297 1 A a DT cord-023134-y665agnh 297 2 value value NN cord-023134-y665agnh 297 3 of of IN cord-023134-y665agnh 297 4 P<0.05 p<0.05 NN cord-023134-y665agnh 297 5 was be VBD cord-023134-y665agnh 297 6 considered consider VBN cord-023134-y665agnh 297 7 significant significant JJ cord-023134-y665agnh 297 8 . . . cord-023134-y665agnh 298 1 Dogs dog NNS cord-023134-y665agnh 298 2 were be VBD cord-023134-y665agnh 298 3 classified classify VBN cord-023134-y665agnh 298 4 as as IN cord-023134-y665agnh 298 5 follows follow VBZ cord-023134-y665agnh 298 6 : : : cord-023134-y665agnh 298 7 28 28 CD cord-023134-y665agnh 298 8 healthy healthy JJ cord-023134-y665agnh 298 9 dogs dog NNS cord-023134-y665agnh 298 10 ; ; : cord-023134-y665agnh 298 11 36 36 CD cord-023134-y665agnh 298 12 dogs dog NNS cord-023134-y665agnh 298 13 in in IN cord-023134-y665agnh 298 14 class class NN cord-023134-y665agnh 298 15 B1 b1 NN cord-023134-y665agnh 298 16 ; ; : cord-023134-y665agnh 298 17 28 28 CD cord-023134-y665agnh 298 18 dogs dog NNS cord-023134-y665agnh 298 19 in in IN cord-023134-y665agnh 298 20 class class NN cord-023134-y665agnh 298 21 B2 b2 NN cord-023134-y665agnh 298 22 ; ; : cord-023134-y665agnh 298 23 22 22 CD cord-023134-y665agnh 298 24 dogs dog NNS cord-023134-y665agnh 298 25 in in IN cord-023134-y665agnh 298 26 class class NN cord-023134-y665agnh 298 27 C c NN cord-023134-y665agnh 298 28 and and CC cord-023134-y665agnh 299 1 D. D. NNP cord-023134-y665agnh 299 2 No no DT cord-023134-y665agnh 299 3 differences difference NNS cord-023134-y665agnh 299 4 were be VBD cord-023134-y665agnh 299 5 found find VBN cord-023134-y665agnh 299 6 among among IN cord-023134-y665agnh 299 7 groups group NNS cord-023134-y665agnh 299 8 regarding regard VBG cord-023134-y665agnh 299 9 RV RV NNP cord-023134-y665agnh 299 10 conventional conventional JJ cord-023134-y665agnh 299 11 Doppler doppler NN cord-023134-y665agnh 299 12 and and CC cord-023134-y665agnh 299 13 PW pw NN cord-023134-y665agnh 299 14 - - HYPH cord-023134-y665agnh 299 15 TDI tdi NN cord-023134-y665agnh 299 16 parameters parameter NNS cord-023134-y665agnh 299 17 . . . cord-023134-y665agnh 300 1 However however RB cord-023134-y665agnh 300 2 , , , cord-023134-y665agnh 300 3 a a DT cord-023134-y665agnh 300 4 significant significant JJ cord-023134-y665agnh 300 5 , , , cord-023134-y665agnh 300 6 weak weak JJ cord-023134-y665agnh 300 7 correlation correlation NN cord-023134-y665agnh 300 8 was be VBD cord-023134-y665agnh 300 9 found find VBN cord-023134-y665agnh 300 10 between between IN cord-023134-y665agnh 300 11 some some DT cord-023134-y665agnh 300 12 left left JJ cord-023134-y665agnh 300 13 - - HYPH cord-023134-y665agnh 300 14 sided sided JJ cord-023134-y665agnh 300 15 echocardiographic echocardiographic JJ cord-023134-y665agnh 300 16 parameters parameter NNS cord-023134-y665agnh 300 17 ( ( -LRB- cord-023134-y665agnh 300 18 left left JJ cord-023134-y665agnh 300 19 atrial atrial JJ cord-023134-y665agnh 300 20 dimension dimension NN cord-023134-y665agnh 300 21 ; ; : cord-023134-y665agnh 300 22 end end VB cord-023134-y665agnh 300 23 diastolic diastolic JJ cord-023134-y665agnh 300 24 and and CC cord-023134-y665agnh 300 25 end end VB cord-023134-y665agnh 300 26 systolic systolic JJ cord-023134-y665agnh 300 27 volume volume NN cord-023134-y665agnh 300 28 indexes index NNS cord-023134-y665agnh 300 29 ; ; : cord-023134-y665agnh 300 30 peak peak NN cord-023134-y665agnh 300 31 E E NNP cord-023134-y665agnh 300 32 wave wave NN cord-023134-y665agnh 300 33 and and CC cord-023134-y665agnh 300 34 A a DT cord-023134-y665agnh 300 35 wave wave NN cord-023134-y665agnh 300 36 velocities velocity NNS cord-023134-y665agnh 300 37 and and CC cord-023134-y665agnh 300 38 E e NN cord-023134-y665agnh 300 39 : : : cord-023134-y665agnh 300 40 A a DT cord-023134-y665agnh 300 41 ratio ratio NN cord-023134-y665agnh 300 42 ) ) -RRB- cord-023134-y665agnh 300 43 and and CC cord-023134-y665agnh 300 44 some some DT cord-023134-y665agnh 300 45 RV rv NN cord-023134-y665agnh 300 46 PW pw NN cord-023134-y665agnh 300 47 - - HYPH cord-023134-y665agnh 300 48 TDI tdi NN cord-023134-y665agnh 300 49 parameters parameter NNS cord-023134-y665agnh 300 50 . . . cord-023134-y665agnh 301 1 PH PH NNP cord-023134-y665agnh 301 2 was be VBD cord-023134-y665agnh 301 3 diagnosed diagnose VBN cord-023134-y665agnh 301 4 in in IN cord-023134-y665agnh 301 5 48 48 CD cord-023134-y665agnh 301 6 dogs dog NNS cord-023134-y665agnh 301 7 , , , cord-023134-y665agnh 301 8 while while IN cord-023134-y665agnh 301 9 54 54 CD cord-023134-y665agnh 301 10 dogs dog NNS cord-023134-y665agnh 301 11 were be VBD cord-023134-y665agnh 301 12 deemed deem VBN cord-023134-y665agnh 301 13 without without IN cord-023134-y665agnh 301 14 PH PH NNP cord-023134-y665agnh 301 15 . . . cord-023134-y665agnh 302 1 Dogs dog NNS cord-023134-y665agnh 302 2 with with IN cord-023134-y665agnh 302 3 PH PH NNP cord-023134-y665agnh 302 4 had have VBD cord-023134-y665agnh 302 5 significantly significantly RB cord-023134-y665agnh 302 6 different different JJ cord-023134-y665agnh 302 7 trans trans JJ cord-023134-y665agnh 302 8 - - JJ cord-023134-y665agnh 302 9 mitral mitral JJ cord-023134-y665agnh 302 10 E e NN cord-023134-y665agnh 302 11 and and CC cord-023134-y665agnh 302 12 A a DT cord-023134-y665agnh 302 13 wave wave NN cord-023134-y665agnh 302 14 peak peak NN cord-023134-y665agnh 302 15 velocity velocity NN cord-023134-y665agnh 302 16 and and CC cord-023134-y665agnh 302 17 E e NN cord-023134-y665agnh 302 18 / / SYM cord-023134-y665agnh 302 19 e e NN cord-023134-y665agnh 302 20 ' ' '' cord-023134-y665agnh 302 21 ratio ratio NN cord-023134-y665agnh 302 22 of of IN cord-023134-y665agnh 302 23 lateral lateral JJ cord-023134-y665agnh 302 24 and and CC cord-023134-y665agnh 302 25 septal septal JJ cord-023134-y665agnh 302 26 mitral mitral JJ cord-023134-y665agnh 302 27 annulus annulus NN cord-023134-y665agnh 302 28 . . . cord-023134-y665agnh 303 1 These these DT cord-023134-y665agnh 303 2 two two CD cord-023134-y665agnh 303 3 latter latter JJ cord-023134-y665agnh 303 4 parameters parameter NNS cord-023134-y665agnh 303 5 were be VBD cord-023134-y665agnh 303 6 also also RB cord-023134-y665agnh 303 7 correlated correlate VBN cord-023134-y665agnh 303 8 with with IN cord-023134-y665agnh 303 9 PASP PASP NNP cord-023134-y665agnh 303 10 ( ( -LRB- cord-023134-y665agnh 303 11 R r NN cord-023134-y665agnh 303 12 2 2 CD cord-023134-y665agnh 303 13 = = SYM cord-023134-y665agnh 303 14 0.241 0.241 CD cord-023134-y665agnh 303 15 and and CC cord-023134-y665agnh 303 16 0.338 0.338 CD cord-023134-y665agnh 303 17 , , , cord-023134-y665agnh 303 18 respectively).Our respectively).Our NNP cord-023134-y665agnh 303 19 findings finding NNS cord-023134-y665agnh 303 20 highlight highlight VBP cord-023134-y665agnh 303 21 the the DT cord-023134-y665agnh 303 22 importance importance NN cord-023134-y665agnh 303 23 of of IN cord-023134-y665agnh 303 24 considering consider VBG cord-023134-y665agnh 303 25 ventricular ventricular JJ cord-023134-y665agnh 303 26 interdependence interdependence NN cord-023134-y665agnh 303 27 in in IN cord-023134-y665agnh 303 28 dogs dog NNS cord-023134-y665agnh 303 29 with with IN cord-023134-y665agnh 303 30 MVD MVD NNP cord-023134-y665agnh 303 31 , , , cord-023134-y665agnh 303 32 particularly particularly RB cord-023134-y665agnh 303 33 those those DT cord-023134-y665agnh 303 34 with with IN cord-023134-y665agnh 303 35 PH PH NNP cord-023134-y665agnh 303 36 . . . cord-023134-y665agnh 304 1 During during IN cord-023134-y665agnh 304 2 the the DT cord-023134-y665agnh 304 3 cardiac cardiac JJ cord-023134-y665agnh 304 4 cycle cycle NN cord-023134-y665agnh 304 5 , , , cord-023134-y665agnh 304 6 the the DT cord-023134-y665agnh 304 7 left left JJ cord-023134-y665agnh 304 8 ventricle ventricle NN cord-023134-y665agnh 304 9 ( ( -LRB- cord-023134-y665agnh 304 10 LV LV NNP cord-023134-y665agnh 304 11 ) ) -RRB- cord-023134-y665agnh 304 12 undergo undergo VB cord-023134-y665agnh 304 13 a a DT cord-023134-y665agnh 304 14 complex complex JJ cord-023134-y665agnh 304 15 deformation deformation NN cord-023134-y665agnh 304 16 , , , cord-023134-y665agnh 304 17 consisting consist VBG cord-023134-y665agnh 304 18 of of IN cord-023134-y665agnh 304 19 overall overall JJ cord-023134-y665agnh 304 20 shortening shorten VBG cord-023134-y665agnh 304 21 accompanied accompany VBN cord-023134-y665agnh 304 22 by by IN cord-023134-y665agnh 304 23 increase increase NN cord-023134-y665agnh 304 24 in in IN cord-023134-y665agnh 304 25 wall wall NN cord-023134-y665agnh 304 26 thickness thickness NN cord-023134-y665agnh 304 27 and and CC cord-023134-y665agnh 304 28 twisting twisting NN cord-023134-y665agnh 304 29 due due IN cord-023134-y665agnh 304 30 to to IN cord-023134-y665agnh 304 31 the the DT cord-023134-y665agnh 304 32 helical helical JJ cord-023134-y665agnh 304 33 orientation orientation NN cord-023134-y665agnh 304 34 of of IN cord-023134-y665agnh 304 35 the the DT cord-023134-y665agnh 304 36 myocardial myocardial JJ cord-023134-y665agnh 304 37 fibers fiber NNS cord-023134-y665agnh 304 38 . . . cord-023134-y665agnh 305 1 Using use VBG cord-023134-y665agnh 305 2 speckle speckle NN cord-023134-y665agnh 305 3 tracking tracking NN cord-023134-y665agnh 305 4 echocardiography echocardiography NN cord-023134-y665agnh 305 5 ( ( -LRB- cord-023134-y665agnh 305 6 STE STE NNP cord-023134-y665agnh 305 7 ) ) -RRB- cord-023134-y665agnh 305 8 , , , cord-023134-y665agnh 305 9 the the DT cord-023134-y665agnh 305 10 circumferential circumferential JJ cord-023134-y665agnh 305 11 strain strain NN cord-023134-y665agnh 305 12 ( ( -LRB- cord-023134-y665agnh 305 13 CS CS NNP cord-023134-y665agnh 305 14 ) ) -RRB- cord-023134-y665agnh 305 15 as as RB cord-023134-y665agnh 305 16 well well RB cord-023134-y665agnh 305 17 as as IN cord-023134-y665agnh 305 18 the the DT cord-023134-y665agnh 305 19 twisting twist VBG cord-023134-y665agnh 305 20 motion motion NN cord-023134-y665agnh 305 21 of of IN cord-023134-y665agnh 305 22 the the DT cord-023134-y665agnh 305 23 LV LV NNP cord-023134-y665agnh 305 24 , , , cord-023134-y665agnh 305 25 calculated calculate VBN cord-023134-y665agnh 305 26 as as IN cord-023134-y665agnh 305 27 the the DT cord-023134-y665agnh 305 28 net net JJ cord-023134-y665agnh 305 29 difference difference NN cord-023134-y665agnh 305 30 between between IN cord-023134-y665agnh 305 31 LV LV NNP cord-023134-y665agnh 305 32 apical apical JJ cord-023134-y665agnh 305 33 and and CC cord-023134-y665agnh 305 34 basal basal NN cord-023134-y665agnh 305 35 rotation rotation NN cord-023134-y665agnh 305 36 angles angle NNS cord-023134-y665agnh 305 37 during during IN cord-023134-y665agnh 305 38 the the DT cord-023134-y665agnh 305 39 cardiac cardiac JJ cord-023134-y665agnh 305 40 cycle cycle NN cord-023134-y665agnh 305 41 , , , cord-023134-y665agnh 305 42 can can MD cord-023134-y665agnh 305 43 be be VB cord-023134-y665agnh 305 44 quantified quantify VBN cord-023134-y665agnh 305 45 by by IN cord-023134-y665agnh 305 46 post post JJ cord-023134-y665agnh 305 47 - - JJ cord-023134-y665agnh 305 48 processing processing JJ cord-023134-y665agnh 305 49 2-dimensional 2-dimensional JJ cord-023134-y665agnh 305 50 short short JJ cord-023134-y665agnh 305 51 axis axis NN cord-023134-y665agnh 305 52 images image NNS cord-023134-y665agnh 305 53 of of IN cord-023134-y665agnh 305 54 the the DT cord-023134-y665agnh 305 55 LV LV NNP cord-023134-y665agnh 305 56 . . . cord-023134-y665agnh 306 1 Thus thus RB cord-023134-y665agnh 306 2 , , , cord-023134-y665agnh 306 3 the the DT cord-023134-y665agnh 306 4 aim aim NN cord-023134-y665agnh 306 5 of of IN cord-023134-y665agnh 306 6 this this DT cord-023134-y665agnh 306 7 study study NN cord-023134-y665agnh 306 8 was be VBD cord-023134-y665agnh 306 9 to to TO cord-023134-y665agnh 306 10 evaluate evaluate VB cord-023134-y665agnh 306 11 the the DT cord-023134-y665agnh 306 12 global global JJ cord-023134-y665agnh 306 13 CS CS NNP cord-023134-y665agnh 306 14 and and CC cord-023134-y665agnh 306 15 the the DT cord-023134-y665agnh 306 16 twisting twist VBG cord-023134-y665agnh 306 17 motion motion NN cord-023134-y665agnh 306 18 in in IN cord-023134-y665agnh 306 19 101 101 CD cord-023134-y665agnh 306 20 small small JJ cord-023134-y665agnh 306 21 - - HYPH cord-023134-y665agnh 306 22 medium medium NN cord-023134-y665agnh 306 23 sized sized JJ cord-023134-y665agnh 306 24 dogs dog NNS cord-023134-y665agnh 306 25 with with IN cord-023134-y665agnh 306 26 varying vary VBG cord-023134-y665agnh 306 27 severity severity NN cord-023134-y665agnh 306 28 of of IN cord-023134-y665agnh 306 29 MR MR NNP cord-023134-y665agnh 306 30 attributable attributable JJ cord-023134-y665agnh 306 31 to to IN cord-023134-y665agnh 306 32 myxomatous myxomatous JJ cord-023134-y665agnh 306 33 mitral mitral JJ cord-023134-y665agnh 306 34 valve valve NN cord-023134-y665agnh 306 35 disease disease NN cord-023134-y665agnh 306 36 ( ( -LRB- cord-023134-y665agnh 306 37 MMVD MMVD NNP cord-023134-y665agnh 306 38 ) ) -RRB- cord-023134-y665agnh 306 39 . . . cord-023134-y665agnh 307 1 Using use VBG cord-023134-y665agnh 307 2 a a DT cord-023134-y665agnh 307 3 Vivid Vivid NNP cord-023134-y665agnh 307 4 - - : cord-023134-y665agnh 307 5 i i PRP cord-023134-y665agnh 307 6 ultrasound ultrasound NN cord-023134-y665agnh 307 7 system system NN cord-023134-y665agnh 307 8 , , , cord-023134-y665agnh 307 9 all all DT cord-023134-y665agnh 307 10 dogs dog NNS cord-023134-y665agnh 307 11 underwent undergo VBD cord-023134-y665agnh 307 12 echocardiography echocardiography NN cord-023134-y665agnh 307 13 including include VBG cord-023134-y665agnh 307 14 parasternal parasternal JJ cord-023134-y665agnh 307 15 short short JJ cord-023134-y665agnh 307 16 axis axis NN cord-023134-y665agnh 307 17 views view NNS cord-023134-y665agnh 307 18 at at IN cord-023134-y665agnh 307 19 the the DT cord-023134-y665agnh 307 20 basal basal NN cord-023134-y665agnh 307 21 and and CC cord-023134-y665agnh 307 22 apical apical JJ cord-023134-y665agnh 307 23 level level NN cord-023134-y665agnh 307 24 for for IN cord-023134-y665agnh 307 25 offline offline JJ cord-023134-y665agnh 307 26 analysis analysis NN cord-023134-y665agnh 307 27 of of IN cord-023134-y665agnh 307 28 rotation rotation NN cord-023134-y665agnh 307 29 , , , cord-023134-y665agnh 307 30 and and CC cord-023134-y665agnh 307 31 at at IN cord-023134-y665agnh 307 32 the the DT cord-023134-y665agnh 307 33 midpapillary midpapillary JJ cord-023134-y665agnh 307 34 muscle muscle NN cord-023134-y665agnh 307 35 level level NN cord-023134-y665agnh 307 36 for for IN cord-023134-y665agnh 307 37 analysis analysis NN cord-023134-y665agnh 307 38 of of IN cord-023134-y665agnh 307 39 global global JJ cord-023134-y665agnh 307 40 CS CS NNP cord-023134-y665agnh 307 41 , , , cord-023134-y665agnh 307 42 using use VBG cord-023134-y665agnh 307 43 commercially commercially RB cord-023134-y665agnh 307 44 available available JJ cord-023134-y665agnh 307 45 software software NN cord-023134-y665agnh 307 46 ( ( -LRB- cord-023134-y665agnh 307 47 EchoPAC echopac NN cord-023134-y665agnh 307 48 ) ) -RRB- cord-023134-y665agnh 307 49 . . . cord-023134-y665agnh 308 1 Twisting twist VBG cord-023134-y665agnh 308 2 motion motion NN cord-023134-y665agnh 308 3 during during IN cord-023134-y665agnh 308 4 systole systole NN cord-023134-y665agnh 308 5 ( ( -LRB- cord-023134-y665agnh 308 6 Twist Twist NNP cord-023134-y665agnh 308 7 SYS SYS NNP cord-023134-y665agnh 308 8 ) ) -RRB- cord-023134-y665agnh 308 9 , , , cord-023134-y665agnh 308 10 early early JJ cord-023134-y665agnh 308 11 ( ( -LRB- cord-023134-y665agnh 308 12 Untwist untwist VB cord-023134-y665agnh 308 13 EARLY early JJ cord-023134-y665agnh 308 14 ) ) -RRB- cord-023134-y665agnh 308 15 and and CC cord-023134-y665agnh 308 16 late late JJ cord-023134-y665agnh 308 17 ( ( -LRB- cord-023134-y665agnh 308 18 Untwist untwist VB cord-023134-y665agnh 308 19 LATE late RB cord-023134-y665agnh 308 20 ) ) -RRB- cord-023134-y665agnh 308 21 diastole diastole NN cord-023134-y665agnh 308 22 were be VBD cord-023134-y665agnh 308 23 calculated calculate VBN cord-023134-y665agnh 308 24 as as RB cord-023134-y665agnh 308 25 well well RB cord-023134-y665agnh 308 26 as as IN cord-023134-y665agnh 308 27 their -PRON- PRP$ cord-023134-y665agnh 308 28 rates rate NNS cord-023134-y665agnh 308 29 computed compute VBN cord-023134-y665agnh 308 30 as as IN cord-023134-y665agnh 308 31 the the DT cord-023134-y665agnh 308 32 time time NN cord-023134-y665agnh 308 33 derivatives derivative NNS cord-023134-y665agnh 308 34 . . . cord-023134-y665agnh 309 1 Furthermore furthermore RB cord-023134-y665agnh 309 2 , , , cord-023134-y665agnh 309 3 time time NN cord-023134-y665agnh 309 4 to to IN cord-023134-y665agnh 309 5 onset onset NN cord-023134-y665agnh 309 6 of of IN cord-023134-y665agnh 309 7 untwist untwist NN cord-023134-y665agnh 309 8 , , , cord-023134-y665agnh 309 9 calculated calculate VBN cord-023134-y665agnh 309 10 from from IN cord-023134-y665agnh 309 11 start start NN cord-023134-y665agnh 309 12 of of IN cord-023134-y665agnh 309 13 electromechanical electromechanical JJ cord-023134-y665agnh 309 14 activation activation NN cord-023134-y665agnh 309 15 until until IN cord-023134-y665agnh 309 16 peak peak NNP cord-023134-y665agnh 309 17 Twist Twist NNP cord-023134-y665agnh 309 18 SYS SYS NNP cord-023134-y665agnh 309 19 was be VBD cord-023134-y665agnh 309 20 measured measure VBN cord-023134-y665agnh 309 21 . . . cord-023134-y665agnh 310 1 Associations association NNS cord-023134-y665agnh 310 2 between between IN cord-023134-y665agnh 310 3 twist twist NN cord-023134-y665agnh 310 4 and and CC cord-023134-y665agnh 310 5 untwist untwist VB cord-023134-y665agnh 310 6 variables variable NNS cord-023134-y665agnh 310 7 , , , cord-023134-y665agnh 310 8 global global JJ cord-023134-y665agnh 310 9 CS cs NN cord-023134-y665agnh 310 10 and and CC cord-023134-y665agnh 310 11 conventional conventional JJ cord-023134-y665agnh 310 12 echocardiographic echocardiographic JJ cord-023134-y665agnh 310 13 indices index NNS cord-023134-y665agnh 310 14 of of IN cord-023134-y665agnh 310 15 MR MR NNP cord-023134-y665agnh 310 16 severity severity NN cord-023134-y665agnh 310 17 and and CC cord-023134-y665agnh 310 18 LV LV NNP cord-023134-y665agnh 310 19 remodeling remodeling NN cord-023134-y665agnh 310 20 were be VBD cord-023134-y665agnh 310 21 examined examine VBN cord-023134-y665agnh 310 22 by by IN cord-023134-y665agnh 310 23 multiple multiple JJ cord-023134-y665agnh 310 24 linear linear JJ cord-023134-y665agnh 310 25 regression regression NN cord-023134-y665agnh 310 26 analyses analysis NNS cord-023134-y665agnh 310 27 including include VBG cord-023134-y665agnh 310 28 dog dog NN cord-023134-y665agnh 310 29 characteristics characteristic NNS cord-023134-y665agnh 310 30 such such JJ cord-023134-y665agnh 310 31 as as IN cord-023134-y665agnh 310 32 heart heart NN cord-023134-y665agnh 310 33 rate rate NN cord-023134-y665agnh 310 34 ( ( -LRB- cord-023134-y665agnh 310 35 HR HR NNP cord-023134-y665agnh 310 36 ) ) -RRB- cord-023134-y665agnh 310 37 , , , cord-023134-y665agnh 310 38 sex sex NN cord-023134-y665agnh 310 39 , , , cord-023134-y665agnh 310 40 breed breed NN cord-023134-y665agnh 310 41 , , , cord-023134-y665agnh 310 42 body body NN cord-023134-y665agnh 310 43 weight weight NN cord-023134-y665agnh 310 44 and and CC cord-023134-y665agnh 310 45 age age NN cord-023134-y665agnh 310 46 . . . cord-023134-y665agnh 311 1 Global global JJ cord-023134-y665agnh 311 2 CS CS NNP cord-023134-y665agnh 311 3 increased increase VBD cord-023134-y665agnh 311 4 with with IN cord-023134-y665agnh 311 5 increasing increase VBG cord-023134-y665agnh 311 6 MR MR NNP cord-023134-y665agnh 311 7 ( ( -LRB- cord-023134-y665agnh 311 8 P p NN cord-023134-y665agnh 311 9 < < XX cord-023134-y665agnh 311 10 0.0001 0.0001 CD cord-023134-y665agnh 311 11 ) ) -RRB- cord-023134-y665agnh 311 12 . . . cord-023134-y665agnh 312 1 Untwist untwist VB cord-023134-y665agnh 312 2 EARLY early JJ cord-023134-y665agnh 312 3 ( ( -LRB- cord-023134-y665agnh 312 4 P p NN cord-023134-y665agnh 312 5 = = SYM cord-023134-y665agnh 312 6 0.0004 0.0004 CD cord-023134-y665agnh 312 7 ) ) -RRB- cord-023134-y665agnh 312 8 and and CC cord-023134-y665agnh 312 9 its -PRON- PRP$ cord-023134-y665agnh 312 10 rate rate NN cord-023134-y665agnh 312 11 ( ( -LRB- cord-023134-y665agnh 312 12 P p NN cord-023134-y665agnh 312 13 = = SYM cord-023134-y665agnh 312 14 0.0008 0.0008 CD cord-023134-y665agnh 312 15 ) ) -RRB- cord-023134-y665agnh 312 16 also also RB cord-023134-y665agnh 312 17 increased increase VBD cord-023134-y665agnh 312 18 with with IN cord-023134-y665agnh 312 19 increasing increase VBG cord-023134-y665agnh 312 20 MR MR NNP cord-023134-y665agnh 312 21 , , , cord-023134-y665agnh 312 22 albeit albeit IN cord-023134-y665agnh 312 23 in in IN cord-023134-y665agnh 312 24 co co NN cord-023134-y665agnh 312 25 - - NN cord-023134-y665agnh 312 26 variation variation NN cord-023134-y665agnh 312 27 with with IN cord-023134-y665agnh 312 28 certain certain JJ cord-023134-y665agnh 312 29 baseline baseline JJ cord-023134-y665agnh 312 30 dog dog NN cord-023134-y665agnh 312 31 characteristics characteristic NNS cord-023134-y665agnh 312 32 . . . cord-023134-y665agnh 313 1 Time time NN cord-023134-y665agnh 313 2 to to IN cord-023134-y665agnh 313 3 onset onset NN cord-023134-y665agnh 313 4 of of IN cord-023134-y665agnh 313 5 untwist untwist NN cord-023134-y665agnh 313 6 increased increase VBD cord-023134-y665agnh 313 7 with with IN cord-023134-y665agnh 313 8 MR MR NNP cord-023134-y665agnh 313 9 ( ( -LRB- cord-023134-y665agnh 313 10 P p NN cord-023134-y665agnh 313 11 = = SYM cord-023134-y665agnh 313 12 0.0005 0.0005 CD cord-023134-y665agnh 313 13 ) ) -RRB- cord-023134-y665agnh 313 14 , , , cord-023134-y665agnh 313 15 left leave VBD cord-023134-y665agnh 313 16 atrium atrium NN cord-023134-y665agnh 313 17 to to IN cord-023134-y665agnh 313 18 aortic aortic JJ cord-023134-y665agnh 313 19 root root NN cord-023134-y665agnh 313 20 ratio ratio NN cord-023134-y665agnh 313 21 ( ( -LRB- cord-023134-y665agnh 313 22 P p NN cord-023134-y665agnh 313 23 = = SYM cord-023134-y665agnh 313 24 0.0007 0.0007 CD cord-023134-y665agnh 313 25 ) ) -RRB- cord-023134-y665agnh 313 26 and and CC cord-023134-y665agnh 313 27 LV LV NNP cord-023134-y665agnh 313 28 internal internal JJ cord-023134-y665agnh 313 29 diameter diameter NN cord-023134-y665agnh 313 30 in in IN cord-023134-y665agnh 313 31 diastole diastole NN cord-023134-y665agnh 313 32 ( ( -LRB- cord-023134-y665agnh 313 33 P p NN cord-023134-y665agnh 313 34 < < XX cord-023134-y665agnh 313 35 0.0001 0.0001 CD cord-023134-y665agnh 313 36 ) ) -RRB- cord-023134-y665agnh 313 37 . . . cord-023134-y665agnh 314 1 In in IN cord-023134-y665agnh 314 2 conclusion conclusion NN cord-023134-y665agnh 314 3 , , , cord-023134-y665agnh 314 4 Untwist untwist VB cord-023134-y665agnh 314 5 EARLY early JJ cord-023134-y665agnh 314 6 and and CC cord-023134-y665agnh 314 7 global global JJ cord-023134-y665agnh 314 8 CS cs NN cord-023134-y665agnh 314 9 gradually gradually RB cord-023134-y665agnh 314 10 increased increase VBD cord-023134-y665agnh 314 11 and and CC cord-023134-y665agnh 314 12 the the DT cord-023134-y665agnh 314 13 onset onset NN cord-023134-y665agnh 314 14 of of IN cord-023134-y665agnh 314 15 untwist untwist NN cord-023134-y665agnh 314 16 appeared appear VBD cord-023134-y665agnh 314 17 to to TO cord-023134-y665agnh 314 18 be be VB cord-023134-y665agnh 314 19 delayed delay VBN cord-023134-y665agnh 314 20 with with IN cord-023134-y665agnh 314 21 increasing increase VBG cord-023134-y665agnh 314 22 MR MR NNP cord-023134-y665agnh 314 23 severity severity NN cord-023134-y665agnh 314 24 in in IN cord-023134-y665agnh 314 25 small small JJ cord-023134-y665agnh 314 26 - - HYPH cord-023134-y665agnh 314 27 medium medium NN cord-023134-y665agnh 314 28 sized sized JJ cord-023134-y665agnh 314 29 dogs dog NNS cord-023134-y665agnh 314 30 with with IN cord-023134-y665agnh 314 31 spontaneous spontaneous JJ cord-023134-y665agnh 314 32 MMVD MMVD NNP cord-023134-y665agnh 314 33 . . . cord-023134-y665agnh 315 1 This this DT cord-023134-y665agnh 315 2 hyperdynamic hyperdynamic JJ cord-023134-y665agnh 315 3 stage stage NN cord-023134-y665agnh 315 4 with with IN cord-023134-y665agnh 315 5 a a DT cord-023134-y665agnh 315 6 delay delay NN cord-023134-y665agnh 315 7 in in IN cord-023134-y665agnh 315 8 untwist untwist NN cord-023134-y665agnh 315 9 may may MD cord-023134-y665agnh 315 10 represent represent VB cord-023134-y665agnh 315 11 LV LV NNP cord-023134-y665agnh 315 12 adaptation adaptation NN cord-023134-y665agnh 315 13 to to IN cord-023134-y665agnh 315 14 loading loading NN cord-023134-y665agnh 315 15 conditions condition NNS cord-023134-y665agnh 315 16 in in IN cord-023134-y665agnh 315 17 MMVD MMVD NNP cord-023134-y665agnh 315 18 , , , cord-023134-y665agnh 315 19 but but CC cord-023134-y665agnh 315 20 might may MD cord-023134-y665agnh 315 21 also also RB cord-023134-y665agnh 315 22 indicate indicate VB cord-023134-y665agnh 315 23 mid mid NN cord-023134-y665agnh 315 24 - - JJ cord-023134-y665agnh 315 25 and and CC cord-023134-y665agnh 315 26 subepicardial subepicardial JJ cord-023134-y665agnh 315 27 compensation compensation NN cord-023134-y665agnh 315 28 for for IN cord-023134-y665agnh 315 29 an an DT cord-023134-y665agnh 315 30 early early JJ cord-023134-y665agnh 315 31 LV LV NNP cord-023134-y665agnh 315 32 dysfunction dysfunction NN cord-023134-y665agnh 315 33 , , , cord-023134-y665agnh 315 34 as as IN cord-023134-y665agnh 315 35 reflected reflect VBN cord-023134-y665agnh 315 36 by by IN cord-023134-y665agnh 315 37 delayed delay VBN cord-023134-y665agnh 315 38 onset onset NN cord-023134-y665agnh 315 39 of of IN cord-023134-y665agnh 315 40 relaxation relaxation NN cord-023134-y665agnh 315 41 , , , cord-023134-y665agnh 315 42 as as IN cord-023134-y665agnh 315 43 timing timing NN cord-023134-y665agnh 315 44 of of IN cord-023134-y665agnh 315 45 contraction contraction NN cord-023134-y665agnh 315 46 - - HYPH cord-023134-y665agnh 315 47 relaxation relaxation NN cord-023134-y665agnh 315 48 cross cross NN cord-023134-y665agnh 315 49 over over RP cord-023134-y665agnh 315 50 is be VBZ cord-023134-y665agnh 315 51 the the DT cord-023134-y665agnh 315 52 most most RBS cord-023134-y665agnh 315 53 vulnerable vulnerable JJ cord-023134-y665agnh 315 54 period period NN cord-023134-y665agnh 315 55 of of IN cord-023134-y665agnh 315 56 myocardial myocardial JJ cord-023134-y665agnh 315 57 fiber fiber NN cord-023134-y665agnh 315 58 mechanics mechanic NNS cord-023134-y665agnh 315 59 . . . cord-023134-y665agnh 316 1 Systolic systolic JJ cord-023134-y665agnh 316 2 anterior anterior JJ cord-023134-y665agnh 316 3 motion motion NN cord-023134-y665agnh 316 4 ( ( -LRB- cord-023134-y665agnh 316 5 SAM SAM NNP cord-023134-y665agnh 316 6 ) ) -RRB- cord-023134-y665agnh 316 7 of of IN cord-023134-y665agnh 316 8 the the DT cord-023134-y665agnh 316 9 mitral mitral JJ cord-023134-y665agnh 316 10 valve valve NN cord-023134-y665agnh 316 11 is be VBZ cord-023134-y665agnh 316 12 the the DT cord-023134-y665agnh 316 13 mechanical mechanical JJ cord-023134-y665agnh 316 14 correlate correlate NN cord-023134-y665agnh 316 15 of of IN cord-023134-y665agnh 316 16 left left JJ cord-023134-y665agnh 316 17 ventricular ventricular JJ cord-023134-y665agnh 316 18 outflow outflow JJ cord-023134-y665agnh 316 19 tract tract NN cord-023134-y665agnh 316 20 dynamic dynamic JJ cord-023134-y665agnh 316 21 obstruction obstruction NN cord-023134-y665agnh 316 22 ( ( -LRB- cord-023134-y665agnh 316 23 LVOTDO LVOTDO NNP cord-023134-y665agnh 316 24 ) ) -RRB- cord-023134-y665agnh 316 25 and and CC cord-023134-y665agnh 316 26 has have VBZ cord-023134-y665agnh 316 27 been be VBN cord-023134-y665agnh 316 28 associated associate VBN cord-023134-y665agnh 316 29 with with IN cord-023134-y665agnh 316 30 hypertrophic hypertrophic JJ cord-023134-y665agnh 316 31 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 316 32 ( ( -LRB- cord-023134-y665agnh 316 33 HCM HCM NNP cord-023134-y665agnh 316 34 ) ) -RRB- cord-023134-y665agnh 316 35 in in IN cord-023134-y665agnh 316 36 most most JJS cord-023134-y665agnh 316 37 instances instance NNS cord-023134-y665agnh 316 38 . . . cord-023134-y665agnh 317 1 However however RB cord-023134-y665agnh 317 2 , , , cord-023134-y665agnh 317 3 SAM SAM NNP cord-023134-y665agnh 317 4 without without IN cord-023134-y665agnh 317 5 left leave VBN cord-023134-y665agnh 317 6 ventricular ventricular JJ cord-023134-y665agnh 317 7 hypertrophy hypertrophy NN cord-023134-y665agnh 317 8 or or CC cord-023134-y665agnh 317 9 with with IN cord-023134-y665agnh 317 10 regressing regress VBG cord-023134-y665agnh 317 11 hypertrophy hypertrophy NN cord-023134-y665agnh 317 12 is be VBZ cord-023134-y665agnh 317 13 increasingly increasingly RB cord-023134-y665agnh 317 14 recognised recognise VBN cord-023134-y665agnh 317 15 . . . cord-023134-y665agnh 318 1 The the DT cord-023134-y665agnh 318 2 echocardiographic echocardiographic JJ cord-023134-y665agnh 318 3 studies study NNS cord-023134-y665agnh 318 4 of of IN cord-023134-y665agnh 318 5 12 12 CD cord-023134-y665agnh 318 6 cats cat NNS cord-023134-y665agnh 318 7 , , , cord-023134-y665agnh 318 8 diagnosed diagnose VBN cord-023134-y665agnh 318 9 between between IN cord-023134-y665agnh 318 10 06/2006 06/2006 CD cord-023134-y665agnh 318 11 and and CC cord-023134-y665agnh 318 12 03/2012 03/2012 CD cord-023134-y665agnh 318 13 , , , cord-023134-y665agnh 318 14 with with IN cord-023134-y665agnh 318 15 SAM SAM NNP cord-023134-y665agnh 318 16 without without IN cord-023134-y665agnh 318 17 HCM HCM NNP cord-023134-y665agnh 318 18 ( ( -LRB- cord-023134-y665agnh 318 19 7 7 CD cord-023134-y665agnh 318 20 cats cat NNS cord-023134-y665agnh 318 21 ) ) -RRB- cord-023134-y665agnh 318 22 or or CC cord-023134-y665agnh 318 23 SAM SAM NNP cord-023134-y665agnh 318 24 with with IN cord-023134-y665agnh 318 25 regressing regress VBG cord-023134-y665agnh 318 26 hypertrophy hypertrophy NN cord-023134-y665agnh 318 27 ( ( -LRB- cord-023134-y665agnh 318 28 5 5 CD cord-023134-y665agnh 318 29 cats cat NNS cord-023134-y665agnh 318 30 ) ) -RRB- cord-023134-y665agnh 318 31 were be VBD cord-023134-y665agnh 318 32 reviewed review VBN cord-023134-y665agnh 318 33 for for IN cord-023134-y665agnh 318 34 evaluation evaluation NN cord-023134-y665agnh 318 35 of of IN cord-023134-y665agnh 318 36 the the DT cord-023134-y665agnh 318 37 anatomic anatomic JJ cord-023134-y665agnh 318 38 and and CC cord-023134-y665agnh 318 39 mechanic mechanic JJ cord-023134-y665agnh 318 40 alteration alteration NN cord-023134-y665agnh 318 41 contributing contribute VBG cord-023134-y665agnh 318 42 to to IN cord-023134-y665agnh 318 43 LVOTDO LVOTDO NNP cord-023134-y665agnh 318 44 .Ventriculo .Ventriculo . cord-023134-y665agnh 318 45 - - HYPH cord-023134-y665agnh 318 46 aortic aortic JJ cord-023134-y665agnh 318 47 and and CC cord-023134-y665agnh 318 48 aorto aorto JJ cord-023134-y665agnh 318 49 - - HYPH cord-023134-y665agnh 318 50 septal septal JJ cord-023134-y665agnh 318 51 malalignment malalignment NN cord-023134-y665agnh 318 52 were be VBD cord-023134-y665agnh 318 53 suggested suggest VBN cord-023134-y665agnh 318 54 by by IN cord-023134-y665agnh 318 55 the the DT cord-023134-y665agnh 318 56 significantly significantly RB cord-023134-y665agnh 318 57 narrower narrow JJR cord-023134-y665agnh 318 58 aorto aorto NN cord-023134-y665agnh 318 59 - - HYPH cord-023134-y665agnh 318 60 mitral mitral JJ cord-023134-y665agnh 318 61 ( ( -LRB- cord-023134-y665agnh 318 62 AM AM NNP cord-023134-y665agnh 318 63 ) ) -RRB- cord-023134-y665agnh 318 64 and and CC cord-023134-y665agnh 318 65 aorto aorto JJ cord-023134-y665agnh 318 66 - - HYPH cord-023134-y665agnh 318 67 septal septal JJ cord-023134-y665agnh 318 68 ( ( -LRB- cord-023134-y665agnh 318 69 AS as NN cord-023134-y665agnh 318 70 ) ) -RRB- cord-023134-y665agnh 318 71 angle angle NN cord-023134-y665agnh 318 72 compared compare VBN cord-023134-y665agnh 318 73 to to IN cord-023134-y665agnh 318 74 a a DT cord-023134-y665agnh 318 75 group group NN cord-023134-y665agnh 318 76 of of IN cord-023134-y665agnh 318 77 14 14 CD cord-023134-y665agnh 318 78 control control NN cord-023134-y665agnh 318 79 cats cat NNS cord-023134-y665agnh 318 80 ( ( -LRB- cord-023134-y665agnh 318 81 AS as IN cord-023134-y665agnh 318 82 = = SYM cord-023134-y665agnh 318 83 120 120 CD cord-023134-y665agnh 318 84 versus versus IN cord-023134-y665agnh 318 85 152 152 CD cord-023134-y665agnh 318 86 -p -p NN cord-023134-y665agnh 318 87 = = SYM cord-023134-y665agnh 318 88 0.007 0.007 CD cord-023134-y665agnh 318 89 ; ; : cord-023134-y665agnh 318 90 AM AM NNP cord-023134-y665agnh 318 91 = = SYM cord-023134-y665agnh 318 92 14 14 CD cord-023134-y665agnh 318 93 versus versus IN cord-023134-y665agnh 318 94 157 157 CD cord-023134-y665agnh 318 95 -p -p . cord-023134-y665agnh 319 1 = = NFP cord-023134-y665agnh 320 1 0.014).Other 0.014).other CD cord-023134-y665agnh 320 2 anatomic anatomic JJ cord-023134-y665agnh 320 3 alterations alteration NNS cord-023134-y665agnh 320 4 of of IN cord-023134-y665agnh 320 5 the the DT cord-023134-y665agnh 320 6 LVOT LVOT NNP cord-023134-y665agnh 320 7 constituents constituent NNS cord-023134-y665agnh 320 8 included include VBD cord-023134-y665agnh 320 9 false false JJ cord-023134-y665agnh 320 10 tendon tendon NN cord-023134-y665agnh 320 11 inserted insert VBN cord-023134-y665agnh 320 12 on on IN cord-023134-y665agnh 320 13 the the DT cord-023134-y665agnh 320 14 septal septal JJ cord-023134-y665agnh 320 15 crest crest NN cord-023134-y665agnh 320 16 ( ( -LRB- cord-023134-y665agnh 320 17 11/12 11/12 CD cord-023134-y665agnh 320 18 ) ) -RRB- cord-023134-y665agnh 320 19 , , , cord-023134-y665agnh 320 20 basal basal JJ cord-023134-y665agnh 320 21 septal septal JJ cord-023134-y665agnh 320 22 angulation angulation NN cord-023134-y665agnh 320 23 ( ( -LRB- cord-023134-y665agnh 320 24 7/12 7/12 CD cord-023134-y665agnh 320 25 ) ) -RRB- cord-023134-y665agnh 320 26 , , , cord-023134-y665agnh 320 27 apical apical JJ cord-023134-y665agnh 320 28 displacement displacement NN cord-023134-y665agnh 320 29 of of IN cord-023134-y665agnh 320 30 the the DT cord-023134-y665agnh 320 31 postero postero JJ cord-023134-y665agnh 320 32 - - HYPH cord-023134-y665agnh 320 33 medial medial JJ cord-023134-y665agnh 320 34 or or CC cord-023134-y665agnh 320 35 antero antero JJ cord-023134-y665agnh 320 36 - - HYPH cord-023134-y665agnh 320 37 lateral lateral JJ cord-023134-y665agnh 320 38 papillary papillary JJ cord-023134-y665agnh 320 39 muscle muscle NN cord-023134-y665agnh 320 40 ( ( -LRB- cord-023134-y665agnh 320 41 5/ 5/ CD cord-023134-y665agnh 320 42 12 12 CD cord-023134-y665agnh 320 43 ) ) -RRB- cord-023134-y665agnh 320 44 , , , cord-023134-y665agnh 320 45 bifid bifid NN cord-023134-y665agnh 320 46 / / SYM cord-023134-y665agnh 320 47 accessory accessory JJ cord-023134-y665agnh 320 48 papillary papillary JJ cord-023134-y665agnh 320 49 muscle muscle NN cord-023134-y665agnh 320 50 ( ( -LRB- cord-023134-y665agnh 320 51 1/12 1/12 CD cord-023134-y665agnh 320 52 ) ) -RRB- cord-023134-y665agnh 320 53 , , , cord-023134-y665agnh 320 54 aberrant aberrant JJ cord-023134-y665agnh 320 55 chordal chordal JJ cord-023134-y665agnh 320 56 insertion insertion NN cord-023134-y665agnh 320 57 on on IN cord-023134-y665agnh 320 58 the the DT cord-023134-y665agnh 320 59 septal septal JJ cord-023134-y665agnh 320 60 crest crest NN cord-023134-y665agnh 320 61 ( ( -LRB- cord-023134-y665agnh 320 62 3/12 3/12 CD cord-023134-y665agnh 320 63 ) ) -RRB- cord-023134-y665agnh 320 64 , , , cord-023134-y665agnh 320 65 severe severe JJ cord-023134-y665agnh 320 66 papillary papillary JJ cord-023134-y665agnh 320 67 muscle muscle NN cord-023134-y665agnh 320 68 hypertrophy hypertrophy NN cord-023134-y665agnh 320 69 ( ( -LRB- cord-023134-y665agnh 320 70 3/12 3/12 CD cord-023134-y665agnh 320 71 ) ) -RRB- cord-023134-y665agnh 320 72 , , , cord-023134-y665agnh 320 73 and and CC cord-023134-y665agnh 320 74 thickened thickened JJ cord-023134-y665agnh 320 75 aortic aortic JJ cord-023134-y665agnh 320 76 cusps cusp NNS cord-023134-y665agnh 320 77 with with IN cord-023134-y665agnh 320 78 sub sub JJ cord-023134-y665agnh 320 79 - - JJ cord-023134-y665agnh 320 80 aortic aortic JJ cord-023134-y665agnh 320 81 ancillary ancillary JJ cord-023134-y665agnh 320 82 echoes echo NNS cord-023134-y665agnh 320 83 ( ( -LRB- cord-023134-y665agnh 320 84 5/12).Mechanisms 5/12).mechanisms CD cord-023134-y665agnh 320 85 of of IN cord-023134-y665agnh 320 86 LVOTDO LVOTDO NNP cord-023134-y665agnh 320 87 included include VBD cord-023134-y665agnh 320 88 obstructive obstructive JJ cord-023134-y665agnh 320 89 mitral mitral JJ cord-023134-y665agnh 320 90 septal septal JJ cord-023134-y665agnh 320 91 leaflet leaflet NN cord-023134-y665agnh 320 92 ( ( -LRB- cord-023134-y665agnh 320 93 2/12 2/12 CD cord-023134-y665agnh 320 94 ) ) -RRB- cord-023134-y665agnh 320 95 , , , cord-023134-y665agnh 320 96 protrusion protrusion NN cord-023134-y665agnh 320 97 of of IN cord-023134-y665agnh 320 98 a a DT cord-023134-y665agnh 320 99 displaced displace VBN cord-023134-y665agnh 320 100 papillary papillary JJ cord-023134-y665agnh 320 101 muscle muscle NN cord-023134-y665agnh 320 102 ( ( -LRB- cord-023134-y665agnh 320 103 2/12 2/12 CD cord-023134-y665agnh 320 104 ) ) -RRB- cord-023134-y665agnh 320 105 , , , cord-023134-y665agnh 320 106 impingement impingement NN cord-023134-y665agnh 320 107 of of IN cord-023134-y665agnh 320 108 an an DT cord-023134-y665agnh 320 109 angulated angulated JJ cord-023134-y665agnh 320 110 basal basal NN cord-023134-y665agnh 320 111 septum septum NN cord-023134-y665agnh 320 112 into into IN cord-023134-y665agnh 320 113 the the DT cord-023134-y665agnh 320 114 LVOT LVOT NNP cord-023134-y665agnh 320 115 ( ( -LRB- cord-023134-y665agnh 320 116 7/12 7/12 CD cord-023134-y665agnh 320 117 ) ) -RRB- cord-023134-y665agnh 320 118 , , , cord-023134-y665agnh 320 119 and and CC cord-023134-y665agnh 320 120 mechanical mechanical JJ cord-023134-y665agnh 320 121 LVOT LVOT NNP cord-023134-y665agnh 320 122 narrowing narrow VBG cord-023134-y665agnh 320 123 from from IN cord-023134-y665agnh 320 124 hypertrophic hypertrophic JJ cord-023134-y665agnh 320 125 papillary papillary JJ cord-023134-y665agnh 320 126 muscle muscle NN cord-023134-y665agnh 320 127 ( ( -LRB- cord-023134-y665agnh 320 128 1/12 1/12 CD cord-023134-y665agnh 320 129 ) ) -RRB- cord-023134-y665agnh 320 130 . . . cord-023134-y665agnh 321 1 Basal basal JJ cord-023134-y665agnh 321 2 septal septal JJ cord-023134-y665agnh 321 3 impingement impingement NN cord-023134-y665agnh 321 4 into into IN cord-023134-y665agnh 321 5 the the DT cord-023134-y665agnh 321 6 LVOT LVOT NNP cord-023134-y665agnh 321 7 was be VBD cord-023134-y665agnh 321 8 associated associate VBN cord-023134-y665agnh 321 9 with with IN cord-023134-y665agnh 321 10 apical apical JJ cord-023134-y665agnh 321 11 ballooning ballooning NN cord-023134-y665agnh 321 12 ( ( -LRB- cord-023134-y665agnh 321 13 5/7 5/7 CD cord-023134-y665agnh 321 14 ) ) -RRB- cord-023134-y665agnh 321 15 without without IN cord-023134-y665agnh 321 16 obvious obvious JJ cord-023134-y665agnh 321 17 apical apical JJ cord-023134-y665agnh 321 18 akinesis akinesis NN cord-023134-y665agnh 321 19 . . . cord-023134-y665agnh 322 1 Out out IN cord-023134-y665agnh 322 2 of of IN cord-023134-y665agnh 322 3 7 7 CD cord-023134-y665agnh 322 4 cats cat NNS cord-023134-y665agnh 322 5 with with IN cord-023134-y665agnh 322 6 LVOTDO LVOTDO NNP cord-023134-y665agnh 322 7 without without IN cord-023134-y665agnh 322 8 hypertrophy hypertrophy NN cord-023134-y665agnh 322 9 , , , cord-023134-y665agnh 322 10 4 4 CD cord-023134-y665agnh 322 11 had have VBD cord-023134-y665agnh 322 12 follow follow VB cord-023134-y665agnh 322 13 - - HYPH cord-023134-y665agnh 322 14 up up NN cord-023134-y665agnh 322 15 studies study NNS cord-023134-y665agnh 322 16 ; ; : cord-023134-y665agnh 322 17 only only RB cord-023134-y665agnh 322 18 1 1 CD cord-023134-y665agnh 322 19 cat cat NN cord-023134-y665agnh 322 20 responded respond VBD cord-023134-y665agnh 322 21 positively positively RB cord-023134-y665agnh 322 22 to to IN cord-023134-y665agnh 322 23 atenolol atenolol NN cord-023134-y665agnh 322 24 treatment treatment NN cord-023134-y665agnh 322 25 . . . cord-023134-y665agnh 323 1 All all PDT cord-023134-y665agnh 323 2 the the DT cord-023134-y665agnh 323 3 cats cat NNS cord-023134-y665agnh 323 4 with with IN cord-023134-y665agnh 323 5 initial initial JJ cord-023134-y665agnh 323 6 hypertrophy hypertrophy NN cord-023134-y665agnh 323 7 had have VBD cord-023134-y665agnh 323 8 reverse reverse JJ cord-023134-y665agnh 323 9 remodelling remodelling NN cord-023134-y665agnh 323 10 and and CC cord-023134-y665agnh 323 11 normalised normalised JJ cord-023134-y665agnh 323 12 aortic aortic JJ cord-023134-y665agnh 323 13 ejection ejection NN cord-023134-y665agnh 323 14 velocities velocity NNS cord-023134-y665agnh 323 15 within within IN cord-023134-y665agnh 323 16 1 1 CD cord-023134-y665agnh 323 17 month month NN cord-023134-y665agnh 323 18 to to IN cord-023134-y665agnh 323 19 11 11 CD cord-023134-y665agnh 323 20 month month NN cord-023134-y665agnh 323 21 after after IN cord-023134-y665agnh 323 22 atenolol atenolol NN cord-023134-y665agnh 323 23 treatment treatment NN cord-023134-y665agnh 323 24 initiation initiation NN cord-023134-y665agnh 323 25 ; ; : cord-023134-y665agnh 323 26 1 1 CD cord-023134-y665agnh 323 27 cat cat NN cord-023134-y665agnh 323 28 developed develop VBN cord-023134-y665agnh 323 29 aortic aortic JJ cord-023134-y665agnh 323 30 regurgitation regurgitation NN cord-023134-y665agnh 323 31 . . . cord-023134-y665agnh 324 1 These these DT cord-023134-y665agnh 324 2 data datum NNS cord-023134-y665agnh 324 3 indicate indicate VBP cord-023134-y665agnh 324 4 that that IN cord-023134-y665agnh 324 5 SAM SAM NNP cord-023134-y665agnh 324 6 is be VBZ cord-023134-y665agnh 324 7 not not RB cord-023134-y665agnh 324 8 exclusively exclusively RB cord-023134-y665agnh 324 9 related relate VBN cord-023134-y665agnh 324 10 to to IN cord-023134-y665agnh 324 11 HCM HCM NNP cord-023134-y665agnh 324 12 and and CC cord-023134-y665agnh 324 13 may may MD cord-023134-y665agnh 324 14 be be VB cord-023134-y665agnh 324 15 a a DT cord-023134-y665agnh 324 16 cause cause NN cord-023134-y665agnh 324 17 , , , cord-023134-y665agnh 324 18 not not RB cord-023134-y665agnh 324 19 a a DT cord-023134-y665agnh 324 20 complication complication NN cord-023134-y665agnh 324 21 , , , cord-023134-y665agnh 324 22 of of IN cord-023134-y665agnh 324 23 left left JJ cord-023134-y665agnh 324 24 ventricular ventricular JJ cord-023134-y665agnh 324 25 hypertrophy hypertrophy NN cord-023134-y665agnh 324 26 . . . cord-023134-y665agnh 325 1 Therapies therapy NNS cord-023134-y665agnh 325 2 that that WDT cord-023134-y665agnh 325 3 delay delay VBP cord-023134-y665agnh 325 4 the the DT cord-023134-y665agnh 325 5 onset onset NN cord-023134-y665agnh 325 6 of of IN cord-023134-y665agnh 325 7 congestive congestive JJ cord-023134-y665agnh 325 8 heart heart NN cord-023134-y665agnh 325 9 failure failure NN cord-023134-y665agnh 325 10 ( ( -LRB- cord-023134-y665agnh 325 11 CHF CHF NNP cord-023134-y665agnh 325 12 ) ) -RRB- cord-023134-y665agnh 325 13 in in IN cord-023134-y665agnh 325 14 dogs dog NNS cord-023134-y665agnh 325 15 with with IN cord-023134-y665agnh 325 16 DMVD DMVD NNS cord-023134-y665agnh 325 17 at at IN cord-023134-y665agnh 325 18 risk risk NN cord-023134-y665agnh 325 19 of of IN cord-023134-y665agnh 325 20 disease disease NN cord-023134-y665agnh 325 21 progression progression NN cord-023134-y665agnh 325 22 would would MD cord-023134-y665agnh 325 23 be be VB cord-023134-y665agnh 325 24 clinically clinically RB cord-023134-y665agnh 325 25 beneficial beneficial JJ cord-023134-y665agnh 325 26 . . . cord-023134-y665agnh 326 1 Increases increase NNS cord-023134-y665agnh 326 2 in in IN cord-023134-y665agnh 326 3 LA LA NNP cord-023134-y665agnh 326 4 / / SYM cord-023134-y665agnh 326 5 Ao Ao NNP cord-023134-y665agnh 326 6 , , , cord-023134-y665agnh 326 7 LVEDDN LVEDDN NNP cord-023134-y665agnh 326 8 and and CC cord-023134-y665agnh 326 9 serum serum NN cord-023134-y665agnh 326 10 NT NT NNP cord-023134-y665agnh 326 11 - - HYPH cord-023134-y665agnh 326 12 proBNP probnp NN cord-023134-y665agnh 326 13 and and CC cord-023134-y665agnh 326 14 cTnI cTnI NNP cord-023134-y665agnh 326 15 concentrations concentration NNS cord-023134-y665agnh 326 16 are be VBP cord-023134-y665agnh 326 17 associated associate VBN cord-023134-y665agnh 326 18 with with IN cord-023134-y665agnh 326 19 decreased decrease VBN cord-023134-y665agnh 326 20 survival survival NN cord-023134-y665agnh 326 21 times time NNS cord-023134-y665agnh 326 22 . . . cord-023134-y665agnh 327 1 Activation activation NN cord-023134-y665agnh 327 2 of of IN cord-023134-y665agnh 327 3 the the DT cord-023134-y665agnh 327 4 renin renin NN cord-023134-y665agnh 327 5 - - HYPH cord-023134-y665agnh 327 6 angiotensinaldosterone angiotensinaldosterone NN cord-023134-y665agnh 327 7 system system NN cord-023134-y665agnh 327 8 is be VBZ cord-023134-y665agnh 327 9 implicated implicate VBN cord-023134-y665agnh 327 10 in in IN cord-023134-y665agnh 327 11 cardiac cardiac JJ cord-023134-y665agnh 327 12 remodeling remodeling NN cord-023134-y665agnh 327 13 in in IN cord-023134-y665agnh 327 14 canine canine JJ cord-023134-y665agnh 327 15 DMVD DMVD NNS cord-023134-y665agnh 327 16 . . . cord-023134-y665agnh 328 1 We -PRON- PRP cord-023134-y665agnh 328 2 hypothesised hypothesise VBD cord-023134-y665agnh 328 3 that that DT cord-023134-y665agnh 328 4 administration administration NN cord-023134-y665agnh 328 5 of of IN cord-023134-y665agnh 328 6 spironolactone spironolactone NNP cord-023134-y665agnh 328 7 to to IN cord-023134-y665agnh 328 8 dogs dog NNS cord-023134-y665agnh 328 9 with with IN cord-023134-y665agnh 328 10 compensated compensate VBN cord-023134-y665agnh 328 11 DMVD DMVD NNS cord-023134-y665agnh 328 12 demonstrating demonstrate VBG cord-023134-y665agnh 328 13 the the DT cord-023134-y665agnh 328 14 above above JJ cord-023134-y665agnh 328 15 risk risk NN cord-023134-y665agnh 328 16 factors factor NNS cord-023134-y665agnh 328 17 would would MD cord-023134-y665agnh 328 18 reduce reduce VB cord-023134-y665agnh 328 19 the the DT cord-023134-y665agnh 328 20 rate rate NN cord-023134-y665agnh 328 21 of of IN cord-023134-y665agnh 328 22 cardiac cardiac JJ cord-023134-y665agnh 328 23 remodeling remodeling NN cord-023134-y665agnh 328 24 associated associate VBN cord-023134-y665agnh 328 25 with with IN cord-023134-y665agnh 328 26 progressive progressive JJ cord-023134-y665agnh 328 27 DMVD DMVD NNS cord-023134-y665agnh 328 28 . . . cord-023134-y665agnh 329 1 Dogs dog NNS cord-023134-y665agnh 329 2 with with IN cord-023134-y665agnh 329 3 ACVIM ACVIM NNP cord-023134-y665agnh 329 4 class class NN cord-023134-y665agnh 329 5 B b NN cord-023134-y665agnh 329 6 DMVD DMVD NNP cord-023134-y665agnh 329 7 were be VBD cord-023134-y665agnh 329 8 recruited recruit VBN cord-023134-y665agnh 329 9 to to IN cord-023134-y665agnh 329 10 a a DT cord-023134-y665agnh 329 11 randomized randomized JJ cord-023134-y665agnh 329 12 , , , cord-023134-y665agnh 329 13 blinded blinded JJ cord-023134-y665agnh 329 14 , , , cord-023134-y665agnh 329 15 placebo placebo NN cord-023134-y665agnh 329 16 - - HYPH cord-023134-y665agnh 329 17 controlled control VBN cord-023134-y665agnh 329 18 pilot pilot NN cord-023134-y665agnh 329 19 study study NN cord-023134-y665agnh 329 20 . . . cord-023134-y665agnh 330 1 No no DT cord-023134-y665agnh 330 2 dogs dog NNS cord-023134-y665agnh 330 3 were be VBD cord-023134-y665agnh 330 4 receiving receive VBG cord-023134-y665agnh 330 5 medications medication NNS cord-023134-y665agnh 330 6 for for IN cord-023134-y665agnh 330 7 cardiac cardiac JJ cord-023134-y665agnh 330 8 disease disease NN cord-023134-y665agnh 330 9 . . . cord-023134-y665agnh 331 1 All all DT cord-023134-y665agnh 331 2 dogs dog NNS cord-023134-y665agnh 331 3 demonstrated demonstrate VBD cord-023134-y665agnh 331 4 at at IN cord-023134-y665agnh 331 5 least least RBS cord-023134-y665agnh 331 6 one one CD cord-023134-y665agnh 331 7 of of IN cord-023134-y665agnh 331 8 the the DT cord-023134-y665agnh 331 9 following follow VBG cord-023134-y665agnh 331 10 risk risk NN cord-023134-y665agnh 331 11 factors factor NNS cord-023134-y665agnh 331 12 : : : cord-023134-y665agnh 331 13 echocardiographic echocardiographic JJ cord-023134-y665agnh 331 14 evidence evidence NN cord-023134-y665agnh 331 15 of of IN cord-023134-y665agnh 331 16 cardiomegaly cardiomegaly NN cord-023134-y665agnh 331 17 , , , cord-023134-y665agnh 331 18 NT NT NNP cord-023134-y665agnh 331 19 - - HYPH cord-023134-y665agnh 331 20 proB proB NNP cord-023134-y665agnh 331 21 - - HYPH cord-023134-y665agnh 331 22 NP>550pmol NP>550pmol NNP cord-023134-y665agnh 331 23 / / SYM cord-023134-y665agnh 331 24 L L NNP cord-023134-y665agnh 331 25 , , , cord-023134-y665agnh 331 26 cTnI>0.025ng cTnI>0.025ng NNP cord-023134-y665agnh 331 27 / / SYM cord-023134-y665agnh 331 28 mL. ml. NN cord-023134-y665agnh 332 1 No no DT cord-023134-y665agnh 332 2 dogs dog NNS cord-023134-y665agnh 332 3 had have VBD cord-023134-y665agnh 332 4 evidence evidence NN cord-023134-y665agnh 332 5 of of IN cord-023134-y665agnh 332 6 other other JJ cord-023134-y665agnh 332 7 cardiac cardiac JJ cord-023134-y665agnh 332 8 disease disease NN cord-023134-y665agnh 332 9 or or CC cord-023134-y665agnh 332 10 renal renal JJ cord-023134-y665agnh 332 11 disease disease NN cord-023134-y665agnh 332 12 , , , cord-023134-y665agnh 332 13 hypoadrenocorticism hypoadrenocorticism NN cord-023134-y665agnh 332 14 , , , cord-023134-y665agnh 332 15 hyperkalaemia hyperkalaemia NN cord-023134-y665agnh 332 16 , , , cord-023134-y665agnh 332 17 or or CC cord-023134-y665agnh 332 18 hyponatraemia hyponatraemia NN cord-023134-y665agnh 332 19 . . . cord-023134-y665agnh 333 1 Dogs dog NNS cord-023134-y665agnh 333 2 were be VBD cord-023134-y665agnh 333 3 randomized randomize VBN cord-023134-y665agnh 333 4 to to TO cord-023134-y665agnh 333 5 receive receive VB cord-023134-y665agnh 333 6 spironolactone spironolactone NNP cord-023134-y665agnh 333 7 ( ( -LRB- cord-023134-y665agnh 333 8 2mg 2mg NNP cord-023134-y665agnh 333 9 / / SYM cord-023134-y665agnh 333 10 kg kg CC cord-023134-y665agnh 333 11 orally orally RB cord-023134-y665agnh 333 12 ) ) -RRB- cord-023134-y665agnh 333 13 or or CC cord-023134-y665agnh 333 14 placebo placebo NN cord-023134-y665agnh 333 15 SID SID NNP cord-023134-y665agnh 333 16 for for IN cord-023134-y665agnh 333 17 6 6 CD cord-023134-y665agnh 333 18 months month NNS cord-023134-y665agnh 333 19 . . . cord-023134-y665agnh 334 1 Comparisons comparison NNS cord-023134-y665agnh 334 2 between between IN cord-023134-y665agnh 334 3 groups group NNS cord-023134-y665agnh 334 4 were be VBD cord-023134-y665agnh 334 5 made make VBN cord-023134-y665agnh 334 6 using use VBG cord-023134-y665agnh 334 7 Mann Mann NNP cord-023134-y665agnh 334 8 - - HYPH cord-023134-y665agnh 334 9 Whitney Whitney NNP cord-023134-y665agnh 334 10 tests test VBZ cord-023134-y665agnh 334 11 . . . cord-023134-y665agnh 335 1 Repeated repeat VBN cord-023134-y665agnh 335 2 measures measure NNS cord-023134-y665agnh 335 3 linear linear JJ cord-023134-y665agnh 335 4 models model NNS cord-023134-y665agnh 335 5 were be VBD cord-023134-y665agnh 335 6 constructed construct VBN cord-023134-y665agnh 335 7 to to TO cord-023134-y665agnh 335 8 compare compare VB cord-023134-y665agnh 335 9 the the DT cord-023134-y665agnh 335 10 rate rate NN cord-023134-y665agnh 335 11 of of IN cord-023134-y665agnh 335 12 change change NN cord-023134-y665agnh 335 13 of of IN cord-023134-y665agnh 335 14 variables variable NNS cord-023134-y665agnh 335 15 over over IN cord-023134-y665agnh 335 16 time time NN cord-023134-y665agnh 335 17 . . . cord-023134-y665agnh 336 1 Significance significance NN cord-023134-y665agnh 336 2 was be VBD cord-023134-y665agnh 336 3 set set VBN cord-023134-y665agnh 336 4 at at IN cord-023134-y665agnh 336 5 P<0.05 P<0.05 NNS cord-023134-y665agnh 336 6 . . . cord-023134-y665agnh 337 1 Data datum NNS cord-023134-y665agnh 337 2 were be VBD cord-023134-y665agnh 337 3 analysed analyse VBN cord-023134-y665agnh 337 4 based base VBN cord-023134-y665agnh 337 5 on on IN cord-023134-y665agnh 337 6 the the DT cord-023134-y665agnh 337 7 intention intention NN cord-023134-y665agnh 337 8 to to TO cord-023134-y665agnh 337 9 treat treat VB cord-023134-y665agnh 337 10 . . . cord-023134-y665agnh 338 1 Twenty twenty CD cord-023134-y665agnh 338 2 dogs dog NNS cord-023134-y665agnh 338 3 of of IN cord-023134-y665agnh 338 4 varying vary VBG cord-023134-y665agnh 338 5 breeds breed NNS cord-023134-y665agnh 338 6 were be VBD cord-023134-y665agnh 338 7 enrolled enrol VBN cord-023134-y665agnh 338 8 . . . cord-023134-y665agnh 339 1 Ten ten CD cord-023134-y665agnh 339 2 dogs dog NNS cord-023134-y665agnh 339 3 demonstrated demonstrate VBD cord-023134-y665agnh 339 4 3 3 CD cord-023134-y665agnh 339 5 risk risk NN cord-023134-y665agnh 339 6 factors factor NNS cord-023134-y665agnh 339 7 , , , cord-023134-y665agnh 339 8 7 7 CD cord-023134-y665agnh 339 9 dogs dog NNS cord-023134-y665agnh 339 10 2 2 CD cord-023134-y665agnh 339 11 risk risk NN cord-023134-y665agnh 339 12 factors factor NNS cord-023134-y665agnh 339 13 and and CC cord-023134-y665agnh 339 14 3 3 CD cord-023134-y665agnh 339 15 dogs dog NNS cord-023134-y665agnh 339 16 1 1 CD cord-023134-y665agnh 339 17 risk risk NN cord-023134-y665agnh 339 18 factor factor NN cord-023134-y665agnh 339 19 . . . cord-023134-y665agnh 340 1 Ten ten CD cord-023134-y665agnh 340 2 dogs dog NNS cord-023134-y665agnh 340 3 received receive VBD cord-023134-y665agnh 340 4 placebo placebo NN cord-023134-y665agnh 340 5 ; ; : cord-023134-y665agnh 340 6 age age NN cord-023134-y665agnh 340 7 range range VBP cord-023134-y665agnh 340 8 6.3 6.3 CD cord-023134-y665agnh 340 9 - - HYPH cord-023134-y665agnh 340 10 11.7 11.7 CD cord-023134-y665agnh 340 11 years year NNS cord-023134-y665agnh 341 1 ( ( -LRB- cord-023134-y665agnh 341 2 mean mean VB cord-023134-y665agnh 341 3 ±SD ±sd DT cord-023134-y665agnh 341 4 , , , cord-023134-y665agnh 341 5 9.0±1.7 9.0±1.7 CD cord-023134-y665agnh 341 6 years year NNS cord-023134-y665agnh 341 7 ) ) -RRB- cord-023134-y665agnh 341 8 , , , cord-023134-y665agnh 341 9 body body NN cord-023134-y665agnh 341 10 weight weight NN cord-023134-y665agnh 341 11 range range NN cord-023134-y665agnh 341 12 4.5 4.5 CD cord-023134-y665agnh 341 13 - - HYPH cord-023134-y665agnh 341 14 17.0 17.0 CD cord-023134-y665agnh 341 15 kg kg NNS cord-023134-y665agnh 342 1 ( ( -LRB- cord-023134-y665agnh 342 2 One one CD cord-023134-y665agnh 342 3 dog dog NN cord-023134-y665agnh 342 4 in in IN cord-023134-y665agnh 342 5 this this DT cord-023134-y665agnh 342 6 group group NN cord-023134-y665agnh 342 7 died die VBD cord-023134-y665agnh 342 8 suddenly suddenly RB cord-023134-y665agnh 342 9 , , , cord-023134-y665agnh 342 10 1 1 CD cord-023134-y665agnh 342 11 progressed progress VBD cord-023134-y665agnh 342 12 to to IN cord-023134-y665agnh 342 13 CHF CHF NNP cord-023134-y665agnh 342 14 and and CC cord-023134-y665agnh 342 15 2 2 CD cord-023134-y665agnh 342 16 received receive VBD cord-023134-y665agnh 342 17 suboptimal suboptimal JJ cord-023134-y665agnh 342 18 spironolactone spironolactone NN cord-023134-y665agnh 342 19 dosage dosage NN cord-023134-y665agnh 342 20 . . . cord-023134-y665agnh 343 1 NT NT NNP cord-023134-y665agnh 343 2 - - HYPH cord-023134-y665agnh 343 3 proBNP proBNP NNP cord-023134-y665agnh 343 4 was be VBD cord-023134-y665agnh 343 5 significantly significantly RB cord-023134-y665agnh 343 6 higher high JJR cord-023134-y665agnh 343 7 in in IN cord-023134-y665agnh 343 8 the the DT cord-023134-y665agnh 343 9 spironolactone spironolactone NNP cord-023134-y665agnh 343 10 group group NN cord-023134-y665agnh 343 11 at at IN cord-023134-y665agnh 343 12 baseline baseline NN cord-023134-y665agnh 343 13 . . . cord-023134-y665agnh 344 1 ( ( -LRB- cord-023134-y665agnh 344 2 P=0.010 P=0.010 NNP cord-023134-y665agnh 344 3 ) ) -RRB- cord-023134-y665agnh 344 4 . . . cord-023134-y665agnh 345 1 NT NT NNP cord-023134-y665agnh 345 2 - - HYPH cord-023134-y665agnh 345 3 proBNP probnp NN cord-023134-y665agnh 345 4 ( ( -LRB- cord-023134-y665agnh 345 5 P=0.002 P=0.002 NNP cord-023134-y665agnh 345 6 ) ) -RRB- cord-023134-y665agnh 346 1 , , , cord-023134-y665agnh 346 2 LA LA NNP cord-023134-y665agnh 346 3 / / SYM cord-023134-y665agnh 346 4 Ao Ao NNP cord-023134-y665agnh 346 5 ( ( -LRB- cord-023134-y665agnh 346 6 P=0.002 P=0.002 NNP cord-023134-y665agnh 346 7 ) ) -RRB- cord-023134-y665agnh 346 8 and and CC cord-023134-y665agnh 346 9 LVEDDN LVEDDN NNP cord-023134-y665agnh 346 10 ( ( -LRB- cord-023134-y665agnh 346 11 P=0.001 P=0.001 NNP cord-023134-y665agnh 346 12 ) ) -RRB- cord-023134-y665agnh 346 13 increased increase VBD cord-023134-y665agnh 346 14 over over IN cord-023134-y665agnh 346 15 time time NN cord-023134-y665agnh 346 16 in in IN cord-023134-y665agnh 346 17 the the DT cord-023134-y665agnh 346 18 placebo placebo NN cord-023134-y665agnh 346 19 , , , cord-023134-y665agnh 346 20 but but CC cord-023134-y665agnh 346 21 not not RB cord-023134-y665agnh 346 22 in in IN cord-023134-y665agnh 346 23 the the DT cord-023134-y665agnh 346 24 spironolactone spironolactone NN cord-023134-y665agnh 346 25 , , , cord-023134-y665agnh 346 26 group group NN cord-023134-y665agnh 346 27 . . . cord-023134-y665agnh 347 1 The the DT cord-023134-y665agnh 347 2 rates rate NNS cord-023134-y665agnh 347 3 of of IN cord-023134-y665agnh 347 4 change change NN cord-023134-y665agnh 347 5 of of IN cord-023134-y665agnh 347 6 NT NT NNP cord-023134-y665agnh 347 7 - - HYPH cord-023134-y665agnh 347 8 proBNP probnp NN cord-023134-y665agnh 347 9 ( ( -LRB- cord-023134-y665agnh 347 10 P=0.059 P=0.059 NNP cord-023134-y665agnh 347 11 ) ) -RRB- cord-023134-y665agnh 347 12 , , , cord-023134-y665agnh 347 13 LA LA NNP cord-023134-y665agnh 347 14 / / SYM cord-023134-y665agnh 347 15 Ao Ao NNP cord-023134-y665agnh 347 16 ( ( -LRB- cord-023134-y665agnh 347 17 P=0.062 P=0.062 NNP cord-023134-y665agnh 347 18 ) ) -RRB- cord-023134-y665agnh 347 19 and and CC cord-023134-y665agnh 347 20 LVEDDN LVEDDN NNP cord-023134-y665agnh 347 21 ( ( -LRB- cord-023134-y665agnh 347 22 P=0.072 p=0.072 NN cord-023134-y665agnh 347 23 ) ) -RRB- cord-023134-y665agnh 347 24 approached approach VBD cord-023134-y665agnh 347 25 , , , cord-023134-y665agnh 347 26 but but CC cord-023134-y665agnh 347 27 did do VBD cord-023134-y665agnh 347 28 not not RB cord-023134-y665agnh 347 29 reach reach VB cord-023134-y665agnh 347 30 , , , cord-023134-y665agnh 347 31 significant significant JJ cord-023134-y665agnh 347 32 differences difference NNS cord-023134-y665agnh 347 33 between between IN cord-023134-y665agnh 347 34 groups group NNS cord-023134-y665agnh 347 35 . . . cord-023134-y665agnh 348 1 In in IN cord-023134-y665agnh 348 2 conclusion conclusion NN cord-023134-y665agnh 348 3 , , , cord-023134-y665agnh 348 4 treatment treatment NN cord-023134-y665agnh 348 5 with with IN cord-023134-y665agnh 348 6 spironolactone spironolactone NN cord-023134-y665agnh 348 7 might may MD cord-023134-y665agnh 348 8 slow slow VB cord-023134-y665agnh 348 9 the the DT cord-023134-y665agnh 348 10 rate rate NN cord-023134-y665agnh 348 11 of of IN cord-023134-y665agnh 348 12 increase increase NN cord-023134-y665agnh 348 13 in in IN cord-023134-y665agnh 348 14 cardiac cardiac JJ cord-023134-y665agnh 348 15 size size NN cord-023134-y665agnh 348 16 in in IN cord-023134-y665agnh 348 17 dogs dog NNS cord-023134-y665agnh 348 18 with with IN cord-023134-y665agnh 348 19 ACVIM ACVIM NNP cord-023134-y665agnh 348 20 class class NN cord-023134-y665agnh 348 21 B b NN cord-023134-y665agnh 348 22 DMVD DMVD NNP cord-023134-y665agnh 348 23 showing show VBG cord-023134-y665agnh 348 24 risk risk NN cord-023134-y665agnh 348 25 factors factor NNS cord-023134-y665agnh 348 26 for for IN cord-023134-y665agnh 348 27 poor poor JJ cord-023134-y665agnh 348 28 outcome outcome NN cord-023134-y665agnh 348 29 . . . cord-023134-y665agnh 349 1 Decreasing decrease VBG cord-023134-y665agnh 349 2 the the DT cord-023134-y665agnh 349 3 rate rate NN cord-023134-y665agnh 349 4 of of IN cord-023134-y665agnh 349 5 increase increase NN cord-023134-y665agnh 349 6 in in IN cord-023134-y665agnh 349 7 cardiac cardiac JJ cord-023134-y665agnh 349 8 size size NN cord-023134-y665agnh 349 9 might may MD cord-023134-y665agnh 349 10 delay delay VB cord-023134-y665agnh 349 11 the the DT cord-023134-y665agnh 349 12 onset onset NN cord-023134-y665agnh 349 13 of of IN cord-023134-y665agnh 349 14 CHF CHF NNP cord-023134-y665agnh 349 15 . . . cord-023134-y665agnh 350 1 Further further JJ cord-023134-y665agnh 350 2 studies study NNS cord-023134-y665agnh 350 3 are be VBP cord-023134-y665agnh 350 4 warranted warrant VBN cord-023134-y665agnh 350 5 to to TO cord-023134-y665agnh 350 6 investigate investigate VB cord-023134-y665agnh 350 7 these these DT cord-023134-y665agnh 350 8 hypotheses hypothesis NNS cord-023134-y665agnh 350 9 . . . cord-023134-y665agnh 351 1 Cardiac cardiac JJ cord-023134-y665agnh 351 2 dysfunction dysfunction NN cord-023134-y665agnh 351 3 is be VBZ cord-023134-y665agnh 351 4 a a DT cord-023134-y665agnh 351 5 concern concern NN cord-023134-y665agnh 351 6 in in IN cord-023134-y665agnh 351 7 human human JJ cord-023134-y665agnh 351 8 systemic systemic JJ cord-023134-y665agnh 351 9 inflammatory inflammatory JJ cord-023134-y665agnh 351 10 response response NN cord-023134-y665agnh 351 11 syndrome syndrome NN cord-023134-y665agnh 351 12 ( ( -LRB- cord-023134-y665agnh 351 13 SIRS sirs UH cord-023134-y665agnh 351 14 ) ) -RRB- cord-023134-y665agnh 351 15 patients patient NNS cord-023134-y665agnh 351 16 , , , cord-023134-y665agnh 351 17 where where WRB cord-023134-y665agnh 351 18 increased increase VBN cord-023134-y665agnh 351 19 cardiac cardiac JJ cord-023134-y665agnh 351 20 biomarkers biomarker NNS cord-023134-y665agnh 351 21 and and CC cord-023134-y665agnh 351 22 decreased decrease VBD cord-023134-y665agnh 351 23 cardiac cardiac JJ cord-023134-y665agnh 351 24 function function NN cord-023134-y665agnh 351 25 have have VBP cord-023134-y665agnh 351 26 already already RB cord-023134-y665agnh 351 27 been be VBN cord-023134-y665agnh 351 28 described describe VBN cord-023134-y665agnh 351 29 . . . cord-023134-y665agnh 352 1 In in IN cord-023134-y665agnh 352 2 a a DT cord-023134-y665agnh 352 3 previous previous JJ cord-023134-y665agnh 352 4 canine canine JJ cord-023134-y665agnh 352 5 SIRS SIRS NNP cord-023134-y665agnh 352 6 study study NN cord-023134-y665agnh 352 7 , , , cord-023134-y665agnh 352 8 an an DT cord-023134-y665agnh 352 9 increase increase NN cord-023134-y665agnh 352 10 of of IN cord-023134-y665agnh 352 11 cardiac cardiac JJ cord-023134-y665agnh 352 12 biomarkers biomarker NNS cord-023134-y665agnh 352 13 ( ( -LRB- cord-023134-y665agnh 352 14 NT NT NNP cord-023134-y665agnh 352 15 - - HYPH cord-023134-y665agnh 352 16 proBNP probnp NN cord-023134-y665agnh 352 17 , , , cord-023134-y665agnh 352 18 cTnT ctnt NN cord-023134-y665agnh 352 19 and and CC cord-023134-y665agnh 352 20 lactate lactate NN cord-023134-y665agnh 352 21 ) ) -RRB- cord-023134-y665agnh 352 22 and and CC cord-023134-y665agnh 352 23 their -PRON- PRP$ cord-023134-y665agnh 352 24 prognostic prognostic JJ cord-023134-y665agnh 352 25 value value NN cord-023134-y665agnh 352 26 has have VBZ cord-023134-y665agnh 352 27 been be VBN cord-023134-y665agnh 352 28 established establish VBN cord-023134-y665agnh 352 29 . . . cord-023134-y665agnh 353 1 The the DT cord-023134-y665agnh 353 2 present present JJ cord-023134-y665agnh 353 3 study study NN cord-023134-y665agnh 353 4 evaluated evaluate VBD cord-023134-y665agnh 353 5 the the DT cord-023134-y665agnh 353 6 kinetics kinetic NNS cord-023134-y665agnh 353 7 of of IN cord-023134-y665agnh 353 8 basic basic JJ cord-023134-y665agnh 353 9 echocardiographic echocardiographic JJ cord-023134-y665agnh 353 10 parameters parameter NNS cord-023134-y665agnh 353 11 ( ( -LRB- cord-023134-y665agnh 353 12 Fractional fractional JJ cord-023134-y665agnh 353 13 shortening shortening NN cord-023134-y665agnh 353 14 ( ( -LRB- cord-023134-y665agnh 353 15 FS FS NNP cord-023134-y665agnh 353 16 ) ) -RRB- cord-023134-y665agnh 353 17 and and CC cord-023134-y665agnh 353 18 left leave VBD cord-023134-y665agnh 353 19 ventricular ventricular JJ cord-023134-y665agnh 353 20 ejection ejection NN cord-023134-y665agnh 353 21 fraction fraction NN cord-023134-y665agnh 353 22 ( ( -LRB- cord-023134-y665agnh 353 23 LVEF LVEF NNP cord-023134-y665agnh 353 24 ) ) -RRB- cord-023134-y665agnh 353 25 , , , cord-023134-y665agnh 353 26 which which WDT cord-023134-y665agnh 353 27 both both DT cord-023134-y665agnh 353 28 reflect reflect VBP cord-023134-y665agnh 353 29 systolic systolic JJ cord-023134-y665agnh 353 30 function function NN cord-023134-y665agnh 353 31 ; ; : cord-023134-y665agnh 353 32 and and CC cord-023134-y665agnh 353 33 the the DT cord-023134-y665agnh 353 34 ratio ratio NN cord-023134-y665agnh 353 35 of of IN cord-023134-y665agnh 353 36 the the DT cord-023134-y665agnh 353 37 left left JJ cord-023134-y665agnh 353 38 atrium atrium NN cord-023134-y665agnh 353 39 to to IN cord-023134-y665agnh 353 40 the the DT cord-023134-y665agnh 353 41 aorta aorta NNP cord-023134-y665agnh 354 1 ( ( -LRB- cord-023134-y665agnh 354 2 LA LA NNP cord-023134-y665agnh 354 3 / / SYM cord-023134-y665agnh 354 4 Ao Ao NNP cord-023134-y665agnh 354 5 ) ) -RRB- cord-023134-y665agnh 354 6 , , , cord-023134-y665agnh 354 7 which which WDT cord-023134-y665agnh 354 8 reflects reflect VBZ cord-023134-y665agnh 354 9 preload preload NN cord-023134-y665agnh 354 10 ) ) -RRB- cord-023134-y665agnh 354 11 in in IN cord-023134-y665agnh 354 12 canine canine JJ cord-023134-y665agnh 354 13 SIRS sir NNS cord-023134-y665agnh 354 14 . . . cord-023134-y665agnh 355 1 Our -PRON- PRP$ cord-023134-y665agnh 355 2 hypotheses hypothesis NNS cord-023134-y665agnh 355 3 were be VBD cord-023134-y665agnh 355 4 that that DT cord-023134-y665agnh 355 5 ( ( -LRB- cord-023134-y665agnh 355 6 1 1 CD cord-023134-y665agnh 355 7 ) ) -RRB- cord-023134-y665agnh 355 8 FS FS NNP cord-023134-y665agnh 355 9 , , , cord-023134-y665agnh 355 10 LVEF LVEF NNP cord-023134-y665agnh 355 11 and and CC cord-023134-y665agnh 355 12 LA LA NNP cord-023134-y665agnh 355 13 / / SYM cord-023134-y665agnh 355 14 Ao Ao NNP cord-023134-y665agnh 355 15 are be VBP cord-023134-y665agnh 355 16 altered alter VBN cord-023134-y665agnh 355 17 in in IN cord-023134-y665agnh 355 18 canine canine JJ cord-023134-y665agnh 355 19 SIRS sir NNS cord-023134-y665agnh 355 20 and and CC cord-023134-y665agnh 355 21 ( ( -LRB- cord-023134-y665agnh 355 22 2 2 LS cord-023134-y665agnh 355 23 ) ) -RRB- cord-023134-y665agnh 355 24 that that IN cord-023134-y665agnh 355 25 these these DT cord-023134-y665agnh 355 26 parameters parameter NNS cord-023134-y665agnh 355 27 carry carry VBP cord-023134-y665agnh 355 28 prognostic prognostic JJ cord-023134-y665agnh 355 29 information information NN cord-023134-y665agnh 355 30 . . . cord-023134-y665agnh 356 1 Dogs dog NNS cord-023134-y665agnh 356 2 with with IN cord-023134-y665agnh 356 3 SIRS SIRS NNP cord-023134-y665agnh 356 4 , , , cord-023134-y665agnh 356 5 without without IN cord-023134-y665agnh 356 6 primary primary JJ cord-023134-y665agnh 356 7 cardiac cardiac JJ cord-023134-y665agnh 356 8 disease disease NN cord-023134-y665agnh 356 9 , , , cord-023134-y665agnh 356 10 presenting present VBG cord-023134-y665agnh 356 11 to to IN cord-023134-y665agnh 356 12 the the DT cord-023134-y665agnh 356 13 emergency emergency NN cord-023134-y665agnh 356 14 service service NN cord-023134-y665agnh 356 15 were be VBD cord-023134-y665agnh 356 16 prospectively prospectively RB cord-023134-y665agnh 356 17 included include VBN cord-023134-y665agnh 356 18 from from IN cord-023134-y665agnh 356 19 January January NNP cord-023134-y665agnh 356 20 until until IN cord-023134-y665agnh 356 21 August August NNP cord-023134-y665agnh 356 22 2010 2010 CD cord-023134-y665agnh 356 23 . . . cord-023134-y665agnh 357 1 Cardiac cardiac JJ cord-023134-y665agnh 357 2 ultrasonography ultrasonography NN cord-023134-y665agnh 357 3 was be VBD cord-023134-y665agnh 357 4 performed perform VBN cord-023134-y665agnh 357 5 by by IN cord-023134-y665agnh 357 6 two two CD cord-023134-y665agnh 357 7 veterinarians veterinarian NNS cord-023134-y665agnh 357 8 in in IN cord-023134-y665agnh 357 9 a a DT cord-023134-y665agnh 357 10 standardized standardized JJ cord-023134-y665agnh 357 11 fashion fashion NN cord-023134-y665agnh 357 12 at at IN cord-023134-y665agnh 357 13 initial initial JJ cord-023134-y665agnh 357 14 presentation presentation NN cord-023134-y665agnh 357 15 , , , cord-023134-y665agnh 357 16 after after IN cord-023134-y665agnh 357 17 6 6 CD cord-023134-y665agnh 357 18 ( ( -LRB- cord-023134-y665agnh 357 19 T6 T6 NNP cord-023134-y665agnh 357 20 ) ) -RRB- cord-023134-y665agnh 357 21 , , , cord-023134-y665agnh 357 22 12 12 CD cord-023134-y665agnh 357 23 ( ( -LRB- cord-023134-y665agnh 357 24 T12 T12 NNP cord-023134-y665agnh 357 25 ) ) -RRB- cord-023134-y665agnh 357 26 , , , cord-023134-y665agnh 357 27 24 24 CD cord-023134-y665agnh 357 28 ( ( -LRB- cord-023134-y665agnh 357 29 T24 T24 NNP cord-023134-y665agnh 357 30 ) ) -RRB- cord-023134-y665agnh 357 31 , , , cord-023134-y665agnh 357 32 72 72 CD cord-023134-y665agnh 357 33 ( ( -LRB- cord-023134-y665agnh 357 34 T72 T72 NNP cord-023134-y665agnh 357 35 ) ) -RRB- cord-023134-y665agnh 357 36 hours hour NNS cord-023134-y665agnh 357 37 of of IN cord-023134-y665agnh 357 38 hospitalization hospitalization NN cord-023134-y665agnh 357 39 until until IN cord-023134-y665agnh 357 40 discharge discharge NN cord-023134-y665agnh 357 41 or or CC cord-023134-y665agnh 357 42 death death NN cord-023134-y665agnh 357 43 and and CC cord-023134-y665agnh 357 44 at at IN cord-023134-y665agnh 357 45 a a DT cord-023134-y665agnh 357 46 control control NN cord-023134-y665agnh 357 47 visit visit NN cord-023134-y665agnh 357 48 ( ( -LRB- cord-023134-y665agnh 357 49 T1 T1 NNP cord-023134-y665agnh 357 50 m m NNP cord-023134-y665agnh 357 51 ) ) -RRB- cord-023134-y665agnh 357 52 over over IN cord-023134-y665agnh 357 53 one one CD cord-023134-y665agnh 357 54 month month NN cord-023134-y665agnh 357 55 after after IN cord-023134-y665agnh 357 56 discharge discharge NN cord-023134-y665agnh 357 57 . . . cord-023134-y665agnh 358 1 Dogs dog NNS cord-023134-y665agnh 358 2 were be VBD cord-023134-y665agnh 358 3 classified classify VBN cord-023134-y665agnh 358 4 according accord VBG cord-023134-y665agnh 358 5 to to IN cord-023134-y665agnh 358 6 their -PRON- PRP$ cord-023134-y665agnh 358 7 underlying underlying JJ cord-023134-y665agnh 358 8 disease disease NN cord-023134-y665agnh 358 9 process process NN cord-023134-y665agnh 358 10 : : : cord-023134-y665agnh 358 11 infection infection NN cord-023134-y665agnh 358 12 , , , cord-023134-y665agnh 358 13 neoplasia neoplasia NN cord-023134-y665agnh 358 14 , , , cord-023134-y665agnh 358 15 trauma trauma NN cord-023134-y665agnh 358 16 , , , cord-023134-y665agnh 358 17 gastric gastric JJ cord-023134-y665agnh 358 18 - - HYPH cord-023134-y665agnh 358 19 dilation dilation NN cord-023134-y665agnh 358 20 and and CC cord-023134-y665agnh 358 21 volvulus volvulus NN cord-023134-y665agnh 358 22 ( ( -LRB- cord-023134-y665agnh 358 23 GDV GDV NNP cord-023134-y665agnh 358 24 ) ) -RRB- cord-023134-y665agnh 358 25 , , , cord-023134-y665agnh 358 26 other other JJ cord-023134-y665agnh 358 27 GI GI NNP cord-023134-y665agnh 358 28 diseases disease NNS cord-023134-y665agnh 358 29 , , , cord-023134-y665agnh 358 30 and and CC cord-023134-y665agnh 358 31 miscellaneous miscellaneous JJ cord-023134-y665agnh 358 32 diseases disease NNS cord-023134-y665agnh 358 33 . . . cord-023134-y665agnh 359 1 Statistical statistical JJ cord-023134-y665agnh 359 2 analysis analysis NN cord-023134-y665agnh 359 3 was be VBD cord-023134-y665agnh 359 4 performed perform VBN cord-023134-y665agnh 359 5 with with IN cord-023134-y665agnh 359 6 SAS SAS NNP cord-023134-y665agnh 359 7 . . . cord-023134-y665agnh 360 1 Univariate Univariate NNP cord-023134-y665agnh 360 2 analysis analysis NN cord-023134-y665agnh 360 3 was be VBD cord-023134-y665agnh 360 4 used use VBN cord-023134-y665agnh 360 5 to to TO cord-023134-y665agnh 360 6 assess assess VB cord-023134-y665agnh 360 7 normal normal JJ cord-023134-y665agnh 360 8 distribution distribution NN cord-023134-y665agnh 360 9 . . . cord-023134-y665agnh 361 1 A a DT cord-023134-y665agnh 361 2 mixed mixed JJ cord-023134-y665agnh 361 3 procedure procedure NN cord-023134-y665agnh 361 4 and and CC cord-023134-y665agnh 361 5 a a DT cord-023134-y665agnh 361 6 logistic logistic JJ cord-023134-y665agnh 361 7 procedure procedure NN cord-023134-y665agnh 361 8 was be VBD cord-023134-y665agnh 361 9 performed perform VBN cord-023134-y665agnh 361 10 accordingly accordingly RB cord-023134-y665agnh 361 11 ( ( -LRB- cord-023134-y665agnh 361 12 p p NN cord-023134-y665agnh 361 13 < < XX cord-023134-y665agnh 361 14 0.05).Thirty 0.05).thirty CD cord-023134-y665agnh 361 15 seven seven CD cord-023134-y665agnh 361 16 dogs dog NNS cord-023134-y665agnh 361 17 ( ( -LRB- cord-023134-y665agnh 361 18 infection infection NN cord-023134-y665agnh 361 19 , , , cord-023134-y665agnh 361 20 n=6 n=6 JJ cord-023134-y665agnh 361 21 ; ; : cord-023134-y665agnh 361 22 neoplasia neoplasia NN cord-023134-y665agnh 361 23 , , , cord-023134-y665agnh 361 24 n=4 n=4 JJ cord-023134-y665agnh 361 25 ; ; : cord-023134-y665agnh 361 26 trauma trauma NN cord-023134-y665agnh 361 27 , , , cord-023134-y665agnh 361 28 n=4 n=4 JJ cord-023134-y665agnh 361 29 ; ; . cord-023134-y665agnh 361 30 GDV GDV NNP cord-023134-y665agnh 361 31 , , , cord-023134-y665agnh 361 32 n=4 n=4 JJ cord-023134-y665agnh 361 33 ; ; , cord-023134-y665agnh 361 34 other other JJ cord-023134-y665agnh 361 35 GI GI NNP cord-023134-y665agnh 361 36 , , , cord-023134-y665agnh 361 37 n=4 n=4 JJ cord-023134-y665agnh 361 38 and and CC cord-023134-y665agnh 361 39 miscellaneous miscellaneous JJ cord-023134-y665agnh 361 40 diseases disease NNS cord-023134-y665agnh 361 41 , , , cord-023134-y665agnh 361 42 n=15 n=15 NNP cord-023134-y665agnh 361 43 ) ) -RRB- cord-023134-y665agnh 361 44 were be VBD cord-023134-y665agnh 361 45 included include VBN cord-023134-y665agnh 361 46 . . . cord-023134-y665agnh 362 1 Twenty twenty CD cord-023134-y665agnh 362 2 - - HYPH cord-023134-y665agnh 362 3 eight eight CD cord-023134-y665agnh 362 4 patients patient NNS cord-023134-y665agnh 362 5 survived survive VBD cord-023134-y665agnh 362 6 , , , cord-023134-y665agnh 362 7 while while IN cord-023134-y665agnh 362 8 9 9 CD cord-023134-y665agnh 362 9 did do VBD cord-023134-y665agnh 362 10 not not RB cord-023134-y665agnh 362 11 ( ( -LRB- cord-023134-y665agnh 362 12 died die VBN cord-023134-y665agnh 362 13 , , , cord-023134-y665agnh 362 14 n=3 n=3 NN cord-023134-y665agnh 362 15 ; ; , cord-023134-y665agnh 362 16 euthanasia euthanasia NN cord-023134-y665agnh 362 17 for for IN cord-023134-y665agnh 362 18 financial financial JJ cord-023134-y665agnh 362 19 reasons reason NNS cord-023134-y665agnh 362 20 , , , cord-023134-y665agnh 362 21 n=2 n=2 NNS cord-023134-y665agnh 362 22 ; ; : cord-023134-y665agnh 362 23 euthanasia euthanasia VBN cord-023134-y665agnh 362 24 for for IN cord-023134-y665agnh 362 25 prognostic prognostic JJ cord-023134-y665agnh 362 26 reasons reason NNS cord-023134-y665agnh 362 27 , , , cord-023134-y665agnh 362 28 n=4 n=4 JJ cord-023134-y665agnh 362 29 ) ) -RRB- cord-023134-y665agnh 362 30 . . . cord-023134-y665agnh 363 1 Eleven eleven CD cord-023134-y665agnh 363 2 dogs dog NNS cord-023134-y665agnh 363 3 had have VBD cord-023134-y665agnh 363 4 control control NN cord-023134-y665agnh 363 5 visits visit NNS cord-023134-y665agnh 363 6 , , , cord-023134-y665agnh 363 7 12 12 CD cord-023134-y665agnh 363 8 owners owner NNS cord-023134-y665agnh 363 9 declined decline VBD cord-023134-y665agnh 363 10 a a DT cord-023134-y665agnh 363 11 control control NN cord-023134-y665agnh 363 12 echocardiography echocardiography NN cord-023134-y665agnh 363 13 , , , cord-023134-y665agnh 363 14 2 2 CD cord-023134-y665agnh 363 15 patients patient NNS cord-023134-y665agnh 363 16 were be VBD cord-023134-y665agnh 363 17 lost lose VBN cord-023134-y665agnh 363 18 to to TO cord-023134-y665agnh 363 19 follow follow VB cord-023134-y665agnh 363 20 - - HYPH cord-023134-y665agnh 363 21 up up NN cord-023134-y665agnh 363 22 and and CC cord-023134-y665agnh 363 23 3 3 CD cord-023134-y665agnh 363 24 died die VBD cord-023134-y665agnh 363 25 before before IN cord-023134-y665agnh 363 26 control control NN cord-023134-y665agnh 363 27 visit visit NN cord-023134-y665agnh 363 28 . . . cord-023134-y665agnh 364 1 FS FS NNP cord-023134-y665agnh 364 2 and and CC cord-023134-y665agnh 364 3 LA LA NNP cord-023134-y665agnh 364 4 / / SYM cord-023134-y665agnh 364 5 Ao Ao NNP cord-023134-y665agnh 364 6 were be VBD cord-023134-y665agnh 364 7 significantly significantly RB cord-023134-y665agnh 364 8 correlated correlate VBN cord-023134-y665agnh 364 9 with with IN cord-023134-y665agnh 364 10 survival survival NN cord-023134-y665agnh 364 11 to to TO cord-023134-y665agnh 364 12 discharge discharge NN cord-023134-y665agnh 364 13 , , , cord-023134-y665agnh 364 14 however however RB cord-023134-y665agnh 364 15 LVEF LVEF NNP cord-023134-y665agnh 364 16 was be VBD cord-023134-y665agnh 364 17 not not RB cord-023134-y665agnh 364 18 . . . cord-023134-y665agnh 365 1 Additionally additionally RB cord-023134-y665agnh 365 2 , , , cord-023134-y665agnh 365 3 LVEF LVEF NNP cord-023134-y665agnh 365 4 and and CC cord-023134-y665agnh 365 5 FS FS NNP cord-023134-y665agnh 365 6 did do VBD cord-023134-y665agnh 365 7 not not RB cord-023134-y665agnh 365 8 change change VB cord-023134-y665agnh 365 9 significantly significantly RB cord-023134-y665agnh 365 10 during during IN cord-023134-y665agnh 365 11 hospitalization hospitalization NN cord-023134-y665agnh 365 12 ; ; : cord-023134-y665agnh 365 13 neither neither CC cord-023134-y665agnh 365 14 compared compare VBN cord-023134-y665agnh 365 15 to to IN cord-023134-y665agnh 365 16 T1 T1 NNP cord-023134-y665agnh 365 17 m m NNP cord-023134-y665agnh 365 18 . . . cord-023134-y665agnh 366 1 LA LA NNP cord-023134-y665agnh 366 2 / / SYM cord-023134-y665agnh 366 3 Ao Ao NNP cord-023134-y665agnh 366 4 did do VBD cord-023134-y665agnh 366 5 however however RB cord-023134-y665agnh 366 6 increase increase VB cord-023134-y665agnh 366 7 significantly significantly RB cord-023134-y665agnh 366 8 during during IN cord-023134-y665agnh 366 9 hospitalization hospitalization NN cord-023134-y665agnh 366 10 . . . cord-023134-y665agnh 367 1 LA LA NNP cord-023134-y665agnh 367 2 / / SYM cord-023134-y665agnh 367 3 Ao Ao NNP cord-023134-y665agnh 367 4 at at IN cord-023134-y665agnh 367 5 T0 T0 NNP cord-023134-y665agnh 367 6 ( ( -LRB- cord-023134-y665agnh 367 7 1.03 1.03 CD cord-023134-y665agnh 367 8 ; ; : cord-023134-y665agnh 367 9 0.76 0.76 CD cord-023134-y665agnh 367 10 - - HYPH cord-023134-y665agnh 367 11 1.74 1.74 CD cord-023134-y665agnh 367 12 ) ) -RRB- cord-023134-y665agnh 367 13 differed differ VBD cord-023134-y665agnh 367 14 significantly significantly RB cord-023134-y665agnh 367 15 from from IN cord-023134-y665agnh 367 16 values value NNS cord-023134-y665agnh 367 17 at at IN cord-023134-y665agnh 367 18 T12 T12 NNP cord-023134-y665agnh 367 19 ( ( -LRB- cord-023134-y665agnh 367 20 1.12 1.12 CD cord-023134-y665agnh 367 21 ; ; : cord-023134-y665agnh 367 22 0.84 0.84 CD cord-023134-y665agnh 367 23 - - SYM cord-023134-y665agnh 367 24 1.68 1.68 CD cord-023134-y665agnh 367 25 ) ) -RRB- cord-023134-y665agnh 367 26 , , , cord-023134-y665agnh 367 27 T72 T72 NNP cord-023134-y665agnh 367 28 ( ( -LRB- cord-023134-y665agnh 367 29 1.20 1.20 CD cord-023134-y665agnh 367 30 ; ; : cord-023134-y665agnh 367 31 0.8 0.8 CD cord-023134-y665agnh 367 32 - - HYPH cord-023134-y665agnh 367 33 1.54 1.54 CD cord-023134-y665agnh 367 34 ) ) -RRB- cord-023134-y665agnh 367 35 and and CC cord-023134-y665agnh 367 36 T1 T1 NNP cord-023134-y665agnh 367 37 m m NNP cord-023134-y665agnh 367 38 ( ( -LRB- cord-023134-y665agnh 367 39 1.19 1.19 CD cord-023134-y665agnh 367 40 ; ; : cord-023134-y665agnh 367 41 1.05 1.05 CD cord-023134-y665agnh 367 42 - - HYPH cord-023134-y665agnh 367 43 1.59).Unexpectedly 1.59).unexpectedly NN cord-023134-y665agnh 367 44 , , , cord-023134-y665agnh 367 45 surviving survive VBG cord-023134-y665agnh 367 46 dogs dog NNS cord-023134-y665agnh 367 47 had have VBD cord-023134-y665agnh 367 48 lower low JJR cord-023134-y665agnh 367 49 FS fs NN cord-023134-y665agnh 367 50 ( ( -LRB- cord-023134-y665agnh 367 51 35.7 35.7 CD cord-023134-y665agnh 367 52 % % NN cord-023134-y665agnh 367 53 ; ; : cord-023134-y665agnh 367 54 19 19 CD cord-023134-y665agnh 367 55 - - SYM cord-023134-y665agnh 367 56 64 64 CD cord-023134-y665agnh 367 57 ) ) -RRB- cord-023134-y665agnh 367 58 than than IN cord-023134-y665agnh 367 59 non non NNS cord-023134-y665agnh 367 60 - - NNS cord-023134-y665agnh 367 61 survivors survivor NNS cord-023134-y665agnh 367 62 ( ( -LRB- cord-023134-y665agnh 367 63 44.3 44.3 CD cord-023134-y665agnh 367 64 % % NN cord-023134-y665agnh 367 65 ; ; : cord-023134-y665agnh 367 66 33 33 CD cord-023134-y665agnh 367 67 - - SYM cord-023134-y665agnh 367 68 53 53 CD cord-023134-y665agnh 367 69 ) ) -RRB- cord-023134-y665agnh 367 70 . . . cord-023134-y665agnh 368 1 LA LA NNP cord-023134-y665agnh 368 2 / / SYM cord-023134-y665agnh 368 3 Ao Ao NNP cord-023134-y665agnh 368 4 was be VBD cord-023134-y665agnh 368 5 associated associate VBN cord-023134-y665agnh 368 6 with with IN cord-023134-y665agnh 368 7 survival survival NN cord-023134-y665agnh 368 8 and and CC cord-023134-y665agnh 368 9 increased increase VBD cord-023134-y665agnh 368 10 rapidly rapidly RB cord-023134-y665agnh 368 11 after after IN cord-023134-y665agnh 368 12 hospitalization hospitalization NN cord-023134-y665agnh 368 13 to to IN cord-023134-y665agnh 368 14 values value NNS cord-023134-y665agnh 368 15 similar similar JJ cord-023134-y665agnh 368 16 to to IN cord-023134-y665agnh 368 17 T1 T1 NNP cord-023134-y665agnh 368 18 m m NNP cord-023134-y665agnh 368 19 , , , cord-023134-y665agnh 368 20 which which WDT cord-023134-y665agnh 368 21 probably probably RB cord-023134-y665agnh 368 22 reflects reflect VBZ cord-023134-y665agnh 368 23 the the DT cord-023134-y665agnh 368 24 efficacy efficacy NN cord-023134-y665agnh 368 25 of of IN cord-023134-y665agnh 368 26 fluid fluid JJ cord-023134-y665agnh 368 27 therapy therapy NN cord-023134-y665agnh 368 28 in in IN cord-023134-y665agnh 368 29 emergency emergency NN cord-023134-y665agnh 368 30 cases case NNS cord-023134-y665agnh 368 31 . . . cord-023134-y665agnh 369 1 In in IN cord-023134-y665agnh 369 2 this this DT cord-023134-y665agnh 369 3 population population NN cord-023134-y665agnh 369 4 of of IN cord-023134-y665agnh 369 5 canine canine JJ cord-023134-y665agnh 369 6 SIRS SIRS NNP cord-023134-y665agnh 369 7 patients patient NNS cord-023134-y665agnh 369 8 , , , cord-023134-y665agnh 369 9 no no DT cord-023134-y665agnh 369 10 echocardiographic echocardiographic JJ cord-023134-y665agnh 369 11 evidence evidence NN cord-023134-y665agnh 369 12 of of IN cord-023134-y665agnh 369 13 cardiac cardiac JJ cord-023134-y665agnh 369 14 dysfunction dysfunction NN cord-023134-y665agnh 369 15 was be VBD cord-023134-y665agnh 369 16 demonstrated demonstrate VBN cord-023134-y665agnh 369 17 . . . cord-023134-y665agnh 370 1 Reports report NNS cord-023134-y665agnh 370 2 from from IN cord-023134-y665agnh 370 3 first first JJ cord-023134-y665agnh 370 4 - - HYPH cord-023134-y665agnh 370 5 opinion opinion NN cord-023134-y665agnh 370 6 practice practice NN cord-023134-y665agnh 370 7 of of IN cord-023134-y665agnh 370 8 feline feline JJ cord-023134-y665agnh 370 9 arterial arterial JJ cord-023134-y665agnh 370 10 thromboembolism thromboembolism NN cord-023134-y665agnh 370 11 ( ( -LRB- cord-023134-y665agnh 370 12 ATE eat VBD cord-023134-y665agnh 370 13 ) ) -RRB- cord-023134-y665agnh 370 14 are be VBP cord-023134-y665agnh 370 15 scarce scarce JJ cord-023134-y665agnh 370 16 . . . cord-023134-y665agnh 371 1 Our -PRON- PRP$ cord-023134-y665agnh 371 2 aim aim NN cord-023134-y665agnh 371 3 was be VBD cord-023134-y665agnh 371 4 to to TO cord-023134-y665agnh 371 5 describe describe VB cord-023134-y665agnh 371 6 and and CC cord-023134-y665agnh 371 7 evaluate evaluate VB cord-023134-y665agnh 371 8 the the DT cord-023134-y665agnh 371 9 outcome outcome NN cord-023134-y665agnh 371 10 in in IN cord-023134-y665agnh 371 11 cats cat NNS cord-023134-y665agnh 371 12 with with IN cord-023134-y665agnh 371 13 ATE eat VBD cord-023134-y665agnh 371 14 presenting present VBG cord-023134-y665agnh 371 15 to to IN cord-023134-y665agnh 371 16 three three CD cord-023134-y665agnh 371 17 first first JJ cord-023134-y665agnh 371 18 - - HYPH cord-023134-y665agnh 371 19 opinion opinion NN cord-023134-y665agnh 371 20 clinics clinic NNS cord-023134-y665agnh 371 21 . . . cord-023134-y665agnh 372 1 Clinical clinical JJ cord-023134-y665agnh 372 2 records record NNS cord-023134-y665agnh 372 3 of of IN cord-023134-y665agnh 372 4 cats cat NNS cord-023134-y665agnh 372 5 presenting present VBG cord-023134-y665agnh 372 6 with with IN cord-023134-y665agnh 372 7 ATE eat VBD cord-023134-y665agnh 372 8 between between IN cord-023134-y665agnh 372 9 2004 2004 CD cord-023134-y665agnh 372 10 - - SYM cord-023134-y665agnh 372 11 2012 2012 CD cord-023134-y665agnh 372 12 were be VBD cord-023134-y665agnh 372 13 reviewed review VBN cord-023134-y665agnh 372 14 for for IN cord-023134-y665agnh 372 15 history history NN cord-023134-y665agnh 372 16 , , , cord-023134-y665agnh 372 17 clinical clinical JJ cord-023134-y665agnh 372 18 findings finding NNS cord-023134-y665agnh 372 19 , , , cord-023134-y665agnh 372 20 presence presence NN cord-023134-y665agnh 372 21 of of IN cord-023134-y665agnh 372 22 congestive congestive JJ cord-023134-y665agnh 372 23 heart heart NN cord-023134-y665agnh 372 24 failure failure NN cord-023134-y665agnh 372 25 ( ( -LRB- cord-023134-y665agnh 372 26 CHF CHF NNP cord-023134-y665agnh 372 27 ) ) -RRB- cord-023134-y665agnh 372 28 and and CC cord-023134-y665agnh 372 29 outcome outcome NN cord-023134-y665agnh 372 30 . . . cord-023134-y665agnh 373 1 Kaplan Kaplan NNP cord-023134-y665agnh 373 2 - - HYPH cord-023134-y665agnh 373 3 Meier Meier NNP cord-023134-y665agnh 373 4 and and CC cord-023134-y665agnh 373 5 log log JJ cord-023134-y665agnh 373 6 rank rank NN cord-023134-y665agnh 373 7 analysis analysis NN cord-023134-y665agnh 373 8 was be VBD cord-023134-y665agnh 373 9 performed perform VBN cord-023134-y665agnh 373 10 to to TO cord-023134-y665agnh 373 11 evaluate evaluate VB cord-023134-y665agnh 373 12 associations association NNS cord-023134-y665agnh 373 13 with with IN cord-023134-y665agnh 373 14 survival survival NN cord-023134-y665agnh 373 15 . . . cord-023134-y665agnh 374 1 During during IN cord-023134-y665agnh 374 2 the the DT cord-023134-y665agnh 374 3 study study NN cord-023134-y665agnh 374 4 period period NN cord-023134-y665agnh 374 5 , , , cord-023134-y665agnh 374 6 242 242 CD cord-023134-y665agnh 374 7 cats cat NNS cord-023134-y665agnh 374 8 presented present VBN cord-023134-y665agnh 374 9 with with IN cord-023134-y665agnh 374 10 ATE ATE NNP cord-023134-y665agnh 374 11 ; ; : cord-023134-y665agnh 374 12 an an DT cord-023134-y665agnh 374 13 overall overall JJ cord-023134-y665agnh 374 14 feline feline JJ cord-023134-y665agnh 374 15 incidence incidence NN cord-023134-y665agnh 374 16 of of IN cord-023134-y665agnh 374 17 0.26 0.26 CD cord-023134-y665agnh 374 18 % % NN cord-023134-y665agnh 374 19 . . . cord-023134-y665agnh 375 1 Most Most JJS cord-023134-y665agnh 375 2 cats cat NNS cord-023134-y665agnh 375 3 were be VBD cord-023134-y665agnh 375 4 male male JJ cord-023134-y665agnh 375 5 ( ( -LRB- cord-023134-y665agnh 375 6 58.5 58.5 CD cord-023134-y665agnh 375 7 % % NN cord-023134-y665agnh 375 8 ) ) -RRB- cord-023134-y665agnh 375 9 and and CC cord-023134-y665agnh 375 10 non non JJ cord-023134-y665agnh 375 11 - - JJ cord-023134-y665agnh 375 12 pedigree pedigree JJ cord-023134-y665agnh 375 13 ( ( -LRB- cord-023134-y665agnh 375 14 92.1 92.1 CD cord-023134-y665agnh 375 15 % % NN cord-023134-y665agnh 375 16 ) ) -RRB- cord-023134-y665agnh 375 17 . . . cord-023134-y665agnh 376 1 Signs sign NNS cord-023134-y665agnh 376 2 of of IN cord-023134-y665agnh 376 3 cardiovascular cardiovascular JJ cord-023134-y665agnh 376 4 disease disease NN cord-023134-y665agnh 376 5 prior prior RB cord-023134-y665agnh 376 6 to to IN cord-023134-y665agnh 376 7 ATE eat VBD cord-023134-y665agnh 376 8 included include VBN cord-023134-y665agnh 376 9 cardiomyopathy cardiomyopathy NN cord-023134-y665agnh 376 10 ( ( -LRB- cord-023134-y665agnh 376 11 12 12 CD cord-023134-y665agnh 376 12 % % NN cord-023134-y665agnh 376 13 ) ) -RRB- cord-023134-y665agnh 376 14 , , , cord-023134-y665agnh 376 15 a a DT cord-023134-y665agnh 376 16 heart heart NN cord-023134-y665agnh 376 17 murmur murmur NN cord-023134-y665agnh 376 18 ( ( -LRB- cord-023134-y665agnh 376 19 23.5 23.5 CD cord-023134-y665agnh 376 20 % % NN cord-023134-y665agnh 376 21 ) ) -RRB- cord-023134-y665agnh 376 22 , , , cord-023134-y665agnh 376 23 a a DT cord-023134-y665agnh 376 24 gallop gallop NN cord-023134-y665agnh 376 25 sound sound NN cord-023134-y665agnh 376 26 / / : cord-023134-y665agnh 376 27 arrhythmia arrhythmia NN cord-023134-y665agnh 376 28 ( ( -LRB- cord-023134-y665agnh 376 29 3.3 3.3 CD cord-023134-y665agnh 376 30 % % NN cord-023134-y665agnh 376 31 ) ) -RRB- cord-023134-y665agnh 376 32 and and CC cord-023134-y665agnh 376 33 hyperthyroidism hyperthyroidism NN cord-023134-y665agnh 376 34 ( ( -LRB- cord-023134-y665agnh 376 35 7.1 7.1 CD cord-023134-y665agnh 376 36 % % NN cord-023134-y665agnh 376 37 ) ) -RRB- cord-023134-y665agnh 376 38 . . . cord-023134-y665agnh 377 1 Most Most JJS cord-023134-y665agnh 377 2 cats cat NNS cord-023134-y665agnh 377 3 presented present VBD cord-023134-y665agnh 377 4 within within IN cord-023134-y665agnh 377 5 6 6 CD cord-023134-y665agnh 377 6 hours hour NNS cord-023134-y665agnh 377 7 of of IN cord-023134-y665agnh 377 8 clinical clinical JJ cord-023134-y665agnh 377 9 signs sign NNS cord-023134-y665agnh 377 10 ( ( -LRB- cord-023134-y665agnh 377 11 72.6 72.6 CD cord-023134-y665agnh 377 12 % % NN cord-023134-y665agnh 377 13 ) ) -RRB- cord-023134-y665agnh 377 14 . . . cord-023134-y665agnh 378 1 Median median JJ cord-023134-y665agnh 378 2 age age NN cord-023134-y665agnh 378 3 at at IN cord-023134-y665agnh 378 4 presentation presentation NN cord-023134-y665agnh 378 5 was be VBD cord-023134-y665agnh 378 6 12 12 CD cord-023134-y665agnh 378 7 Atrioventricular Atrioventricular NNP cord-023134-y665agnh 378 8 block block NN cord-023134-y665agnh 378 9 ( ( -LRB- cord-023134-y665agnh 378 10 AVB AVB NNP cord-023134-y665agnh 378 11 ) ) -RRB- cord-023134-y665agnh 378 12 is be VBZ cord-023134-y665agnh 378 13 an an DT cord-023134-y665agnh 378 14 arrhythmia arrhythmia NN cord-023134-y665agnh 378 15 resulting result VBG cord-023134-y665agnh 378 16 from from IN cord-023134-y665agnh 378 17 conduction conduction NN cord-023134-y665agnh 378 18 abnormalities abnormality NNS cord-023134-y665agnh 378 19 through through IN cord-023134-y665agnh 378 20 the the DT cord-023134-y665agnh 378 21 atrioventricular atrioventricular JJ cord-023134-y665agnh 378 22 node node NN cord-023134-y665agnh 378 23 that that WDT cord-023134-y665agnh 378 24 leads lead VBZ cord-023134-y665agnh 378 25 to to IN cord-023134-y665agnh 378 26 severe severe JJ cord-023134-y665agnh 378 27 signs sign NNS cord-023134-y665agnh 378 28 and and CC cord-023134-y665agnh 378 29 sudden sudden JJ cord-023134-y665agnh 378 30 death death NN cord-023134-y665agnh 378 31 . . . cord-023134-y665agnh 379 1 The the DT cord-023134-y665agnh 379 2 aim aim NN cord-023134-y665agnh 379 3 of of IN cord-023134-y665agnh 379 4 this this DT cord-023134-y665agnh 379 5 study study NN cord-023134-y665agnh 379 6 was be VBD cord-023134-y665agnh 379 7 to to TO cord-023134-y665agnh 379 8 evaluate evaluate VB cord-023134-y665agnh 379 9 long long JJ cord-023134-y665agnh 379 10 - - HYPH cord-023134-y665agnh 379 11 term term NN cord-023134-y665agnh 379 12 intrinsic intrinsic JJ cord-023134-y665agnh 379 13 rhythm rhythm NN cord-023134-y665agnh 379 14 variations variation NNS cord-023134-y665agnh 379 15 in in IN cord-023134-y665agnh 379 16 dogs dog NNS cord-023134-y665agnh 379 17 undergone undergo VBN cord-023134-y665agnh 379 18 pacemaker pacemaker NN cord-023134-y665agnh 379 19 ( ( -LRB- cord-023134-y665agnh 379 20 PM pm NN cord-023134-y665agnh 379 21 ) ) -RRB- cord-023134-y665agnh 379 22 implantation implantation NN cord-023134-y665agnh 379 23 . . . cord-023134-y665agnh 380 1 Ninety ninety CD cord-023134-y665agnh 380 2 - - HYPH cord-023134-y665agnh 380 3 two two CD cord-023134-y665agnh 380 4 dogs dog NNS cord-023134-y665agnh 380 5 of of IN cord-023134-y665agnh 380 6 different different JJ cord-023134-y665agnh 380 7 breeds breed NNS cord-023134-y665agnh 380 8 with with IN cord-023134-y665agnh 380 9 3 3 CD cord-023134-y665agnh 380 10 rd rd NN cord-023134-y665agnh 380 11 degree degree NN cord-023134-y665agnh 380 12 AVB AVB NNP cord-023134-y665agnh 380 13 ( ( -LRB- cord-023134-y665agnh 380 14 3AVB 3avb NN cord-023134-y665agnh 380 15 ) ) -RRB- cord-023134-y665agnh 380 16 ( ( -LRB- cord-023134-y665agnh 380 17 59.8 59.8 CD cord-023134-y665agnh 380 18 % % NN cord-023134-y665agnh 380 19 ) ) -RRB- cord-023134-y665agnh 380 20 , , , cord-023134-y665agnh 380 21 advanced advanced JJ cord-023134-y665agnh 380 22 2 2 CD cord-023134-y665agnh 380 23 nd nd NNP cord-023134-y665agnh 380 24 degree degree NN cord-023134-y665agnh 380 25 AVB AVB NNP cord-023134-y665agnh 380 26 ( ( -LRB- cord-023134-y665agnh 380 27 2AVB)(14.1 2avb)(14.1 CD cord-023134-y665agnh 380 28 % % NN cord-023134-y665agnh 380 29 ) ) -RRB- cord-023134-y665agnh 380 30 , , , cord-023134-y665agnh 380 31 paroxysmal paroxysmal JJ cord-023134-y665agnh 380 32 3AVB 3avb NN cord-023134-y665agnh 380 33 ( ( -LRB- cord-023134-y665agnh 380 34 12 12 CD cord-023134-y665agnh 380 35 % % NN cord-023134-y665agnh 380 36 ) ) -RRB- cord-023134-y665agnh 380 37 , , , cord-023134-y665agnh 380 38 2:1 2:1 CD cord-023134-y665agnh 380 39 AVB AVB NNP cord-023134-y665agnh 380 40 ( ( -LRB- cord-023134-y665agnh 380 41 7.6 7.6 CD cord-023134-y665agnh 380 42 % % NN cord-023134-y665agnh 380 43 ) ) -RRB- cord-023134-y665agnh 380 44 and and CC cord-023134-y665agnh 380 45 3AVB 3avb NN cord-023134-y665agnh 380 46 with with IN cord-023134-y665agnh 380 47 atrial atrial JJ cord-023134-y665agnh 380 48 fibrillation fibrillation NN cord-023134-y665agnh 380 49 ( ( -LRB- cord-023134-y665agnh 380 50 6.5 6.5 CD cord-023134-y665agnh 380 51 % % NN cord-023134-y665agnh 380 52 ) ) -RRB- cord-023134-y665agnh 380 53 were be VBD cord-023134-y665agnh 380 54 retrospectively retrospectively RB cord-023134-y665agnh 380 55 analyzed analyze VBN cord-023134-y665agnh 380 56 . . . cord-023134-y665agnh 381 1 Forty forty CD cord-023134-y665agnh 381 2 - - HYPH cord-023134-y665agnh 381 3 nine nine CD cord-023134-y665agnh 381 4 ( ( -LRB- cord-023134-y665agnh 381 5 53.3 53.3 CD cord-023134-y665agnh 381 6 % % NN cord-023134-y665agnh 381 7 ) ) -RRB- cord-023134-y665agnh 381 8 were be VBD cord-023134-y665agnh 381 9 males male NNS cord-023134-y665agnh 381 10 and and CC cord-023134-y665agnh 381 11 43 43 CD cord-023134-y665agnh 381 12 ( ( -LRB- cord-023134-y665agnh 381 13 46.7 46.7 CD cord-023134-y665agnh 381 14 % % NN cord-023134-y665agnh 381 15 ) ) -RRB- cord-023134-y665agnh 381 16 females female NNS cord-023134-y665agnh 381 17 with with IN cord-023134-y665agnh 381 18 a a DT cord-023134-y665agnh 381 19 mean mean JJ cord-023134-y665agnh 381 20 age age NN cord-023134-y665agnh 381 21 of of IN cord-023134-y665agnh 381 22 8.8 8.8 CD cord-023134-y665agnh 381 23 + + SYM cord-023134-y665agnh 381 24 3.3 3.3 CD cord-023134-y665agnh 381 25 ( ( -LRB- cord-023134-y665agnh 381 26 SD SD NNP cord-023134-y665agnh 381 27 ) ) -RRB- cord-023134-y665agnh 381 28 years year NNS cord-023134-y665agnh 381 29 and and CC cord-023134-y665agnh 381 30 a a DT cord-023134-y665agnh 381 31 mean mean JJ cord-023134-y665agnh 381 32 body body NN cord-023134-y665agnh 381 33 weight weight NN cord-023134-y665agnh 381 34 of of IN cord-023134-y665agnh 381 35 26.5 26.5 CD cord-023134-y665agnh 381 36 kg kg NNS cord-023134-y665agnh 381 37 + + CD cord-023134-y665agnh 381 38 12.8 12.8 CD cord-023134-y665agnh 381 39 . . . cord-023134-y665agnh 382 1 The the DT cord-023134-y665agnh 382 2 intrinsic intrinsic JJ cord-023134-y665agnh 382 3 rhythm rhythm NN cord-023134-y665agnh 382 4 was be VBD cord-023134-y665agnh 382 5 evaluated evaluate VBN cord-023134-y665agnh 382 6 the the DT cord-023134-y665agnh 382 7 day day NN cord-023134-y665agnh 382 8 of of IN cord-023134-y665agnh 382 9 PM pm NN cord-023134-y665agnh 382 10 implantation implantation NN cord-023134-y665agnh 382 11 ( ( -LRB- cord-023134-y665agnh 382 12 T0 T0 NNP cord-023134-y665agnh 382 13 ) ) -RRB- cord-023134-y665agnh 382 14 , , , cord-023134-y665agnh 382 15 after after IN cord-023134-y665agnh 382 16 1 1 CD cord-023134-y665agnh 382 17 day day NN cord-023134-y665agnh 382 18 ( ( -LRB- cord-023134-y665agnh 382 19 confidence confidence NN cord-023134-y665agnh 382 20 interval interval NN cord-023134-y665agnh 382 21 95 95 CD cord-023134-y665agnh 382 22 % % NN cord-023134-y665agnh 382 23 [ [ -LRB- cord-023134-y665agnh 382 24 CI CI NNP cord-023134-y665agnh 382 25 95 95 CD cord-023134-y665agnh 382 26 % % NN cord-023134-y665agnh 382 27 ] ] -RRB- cord-023134-y665agnh 382 28 1 1 CD cord-023134-y665agnh 382 29 - - SYM cord-023134-y665agnh 382 30 2 2 CD cord-023134-y665agnh 382 31 ) ) -RRB- cord-023134-y665agnh 383 1 ( ( -LRB- cord-023134-y665agnh 383 2 T1 T1 NNP cord-023134-y665agnh 383 3 ) ) -RRB- cord-023134-y665agnh 383 4 , , , cord-023134-y665agnh 383 5 33 33 CD cord-023134-y665agnh 383 6 days day NNS cord-023134-y665agnh 383 7 ( ( -LRB- cord-023134-y665agnh 383 8 CI CI NNP cord-023134-y665agnh 383 9 95 95 CD cord-023134-y665agnh 383 10 % % NN cord-023134-y665agnh 383 11 28 28 CD cord-023134-y665agnh 383 12 - - SYM cord-023134-y665agnh 383 13 35 35 CD cord-023134-y665agnh 383 14 ) ) -RRB- cord-023134-y665agnh 383 15 ( ( -LRB- cord-023134-y665agnh 383 16 T2 T2 NNP cord-023134-y665agnh 383 17 ) ) -RRB- cord-023134-y665agnh 383 18 , , , cord-023134-y665agnh 383 19 105 105 CD cord-023134-y665agnh 383 20 days day NNS cord-023134-y665agnh 383 21 ( ( -LRB- cord-023134-y665agnh 383 22 CI CI NNP cord-023134-y665agnh 383 23 95 95 CD cord-023134-y665agnh 383 24 % % NN cord-023134-y665agnh 383 25 98 98 CD cord-023134-y665agnh 383 26 - - SYM cord-023134-y665agnh 383 27 156 156 CD cord-023134-y665agnh 383 28 ) ) -RRB- cord-023134-y665agnh 384 1 ( ( -LRB- cord-023134-y665agnh 384 2 T3 T3 NNP cord-023134-y665agnh 384 3 ) ) -RRB- cord-023134-y665agnh 384 4 , , , cord-023134-y665agnh 384 5 275 275 CD cord-023134-y665agnh 384 6 days day NNS cord-023134-y665agnh 384 7 ( ( -LRB- cord-023134-y665agnh 384 8 CI CI NNP cord-023134-y665agnh 384 9 95 95 CD cord-023134-y665agnh 384 10 % % NN cord-023134-y665agnh 384 11 221 221 CD cord-023134-y665agnh 384 12 - - SYM cord-023134-y665agnh 384 13 380 380 CD cord-023134-y665agnh 384 14 ) ) -RRB- cord-023134-y665agnh 384 15 ( ( -LRB- cord-023134-y665agnh 384 16 T4 T4 NNP cord-023134-y665agnh 384 17 ) ) -RRB- cord-023134-y665agnh 384 18 . . . cord-023134-y665agnh 385 1 According accord VBG cord-023134-y665agnh 385 2 to to IN cord-023134-y665agnh 385 3 the the DT cord-023134-y665agnh 385 4 AVB AVB NNP cord-023134-y665agnh 385 5 grade grade NN cord-023134-y665agnh 385 6 at at IN cord-023134-y665agnh 385 7 different different JJ cord-023134-y665agnh 385 8 controls control NNS cord-023134-y665agnh 385 9 , , , cord-023134-y665agnh 385 10 the the DT cord-023134-y665agnh 385 11 rhythm rhythm NN cord-023134-y665agnh 385 12 disturbance disturbance NN cord-023134-y665agnh 385 13 was be VBD cord-023134-y665agnh 385 14 considered consider VBN cord-023134-y665agnh 385 15 advanced advanced JJ cord-023134-y665agnh 385 16 , , , cord-023134-y665agnh 385 17 regressed regressed JJ cord-023134-y665agnh 385 18 or or CC cord-023134-y665agnh 385 19 unchanged unchanged JJ cord-023134-y665agnh 385 20 . . . cord-023134-y665agnh 386 1 Shapiro Shapiro NNP cord-023134-y665agnh 386 2 - - HYPH cord-023134-y665agnh 386 3 Wilk Wilk NNP cord-023134-y665agnh 386 4 and and CC cord-023134-y665agnh 386 5 Kolmogorov Kolmogorov NNP cord-023134-y665agnh 386 6 - - HYPH cord-023134-y665agnh 386 7 Smirnov Smirnov NNP cord-023134-y665agnh 386 8 tests test NNS cord-023134-y665agnh 386 9 were be VBD cord-023134-y665agnh 386 10 used use VBN cord-023134-y665agnh 386 11 to to TO cord-023134-y665agnh 386 12 test test VB cord-023134-y665agnh 386 13 normalcy normalcy NN cord-023134-y665agnh 386 14 , , , cord-023134-y665agnh 386 15 F f NN cord-023134-y665agnh 386 16 - - HYPH cord-023134-y665agnh 386 17 test test NN cord-023134-y665agnh 386 18 to to TO cord-023134-y665agnh 386 19 compare compare VB cord-023134-y665agnh 386 20 means mean NNS cord-023134-y665agnh 386 21 in in IN cord-023134-y665agnh 386 22 a a DT cord-023134-y665agnh 386 23 generalized generalized JJ cord-023134-y665agnh 386 24 linear linear JJ cord-023134-y665agnh 386 25 model model NN cord-023134-y665agnh 386 26 and and CC cord-023134-y665agnh 386 27 Chi Chi NNP cord-023134-y665agnh 386 28 - - HYPH cord-023134-y665agnh 386 29 squared square VBN cord-023134-y665agnh 386 30 to to TO cord-023134-y665agnh 386 31 examine examine VB cord-023134-y665agnh 386 32 the the DT cord-023134-y665agnh 386 33 association association NN cord-023134-y665agnh 386 34 between between IN cord-023134-y665agnh 386 35 categorical categorical JJ cord-023134-y665agnh 386 36 variables variable NNS cord-023134-y665agnh 386 37 and and CC cord-023134-y665agnh 386 38 status status NN cord-023134-y665agnh 386 39 at at IN cord-023134-y665agnh 386 40 each each DT cord-023134-y665agnh 386 41 control control NN cord-023134-y665agnh 386 42 . . . cord-023134-y665agnh 387 1 Sixty Sixty NNP cord-023134-y665agnh 387 2 ( ( -LRB- cord-023134-y665agnh 387 3 65.3 65.3 CD cord-023134-y665agnh 387 4 % % NN cord-023134-y665agnh 387 5 ) ) -RRB- cord-023134-y665agnh 388 1 dogs dog NNS cord-023134-y665agnh 388 2 had have VBD cord-023134-y665agnh 388 3 no no DT cord-023134-y665agnh 388 4 intrinsic intrinsic JJ cord-023134-y665agnh 388 5 rhythm rhythm NN cord-023134-y665agnh 388 6 changes change NNS cord-023134-y665agnh 388 7 , , , cord-023134-y665agnh 388 8 20 20 CD cord-023134-y665agnh 388 9 ( ( -LRB- cord-023134-y665agnh 388 10 21.7 21.7 CD cord-023134-y665agnh 388 11 % % NN cord-023134-y665agnh 388 12 ) ) -RRB- cord-023134-y665agnh 388 13 had have VBD cord-023134-y665agnh 388 14 AVB AVB NNP cord-023134-y665agnh 388 15 progression progression NN cord-023134-y665agnh 388 16 and and CC cord-023134-y665agnh 388 17 12 12 CD cord-023134-y665agnh 388 18 ( ( -LRB- cord-023134-y665agnh 388 19 13 13 CD cord-023134-y665agnh 388 20 % % NN cord-023134-y665agnh 388 21 ) ) -RRB- cord-023134-y665agnh 388 22 had have VBD cord-023134-y665agnh 388 23 AVB AVB NNP cord-023134-y665agnh 388 24 regression regression NN cord-023134-y665agnh 388 25 . . . cord-023134-y665agnh 389 1 Forty forty CD cord-023134-y665agnh 389 2 - - HYPH cord-023134-y665agnh 389 3 eight eight CD cord-023134-y665agnh 389 4 cases case NNS cord-023134-y665agnh 389 5 of of IN cord-023134-y665agnh 389 6 3AVB 3avb NN cord-023134-y665agnh 389 7 remained remain VBD cord-023134-y665agnh 389 8 unchanged unchanged JJ cord-023134-y665agnh 389 9 , , , cord-023134-y665agnh 389 10 while while IN cord-023134-y665agnh 389 11 4 4 CD cord-023134-y665agnh 389 12 regressed regress VBD cord-023134-y665agnh 389 13 to to IN cord-023134-y665agnh 389 14 sinus sinus NN cord-023134-y665agnh 389 15 rhythm rhythm NN cord-023134-y665agnh 389 16 , , , cord-023134-y665agnh 389 17 2 2 CD cord-023134-y665agnh 389 18 to to TO cord-023134-y665agnh 389 19 2:1 2:1 CD cord-023134-y665agnh 389 20 AVB AVB NNP cord-023134-y665agnh 389 21 and and CC cord-023134-y665agnh 389 22 1 1 CD cord-023134-y665agnh 389 23 to to IN cord-023134-y665agnh 389 24 advanced advance VBN cord-023134-y665agnh 389 25 2AVB 2avb CD cord-023134-y665agnh 389 26 . . . cord-023134-y665agnh 390 1 Eight eight CD cord-023134-y665agnh 390 2 advanced advanced JJ cord-023134-y665agnh 390 3 second second JJ cord-023134-y665agnh 390 4 degree degree NN cord-023134-y665agnh 390 5 AVBs avb NNS cord-023134-y665agnh 390 6 progressed progress VBD cord-023134-y665agnh 390 7 to to TO cord-023134-y665agnh 390 8 complete complete VB cord-023134-y665agnh 390 9 AVB AVB NNP cord-023134-y665agnh 390 10 , , , cord-023134-y665agnh 390 11 2 2 CD cord-023134-y665agnh 390 12 regressed regress VBD cord-023134-y665agnh 390 13 to to IN cord-023134-y665agnh 390 14 sinus sinus NN cord-023134-y665agnh 390 15 rhythm rhythm NN cord-023134-y665agnh 390 16 , , . cord-023134-y665agnh 391 1 1 1 CD cord-023134-y665agnh 391 2 to to IN cord-023134-y665agnh 391 3 2:1 2:1 CD cord-023134-y665agnh 391 4 AVB AVB NNP cord-023134-y665agnh 391 5 and and CC cord-023134-y665agnh 391 6 2 2 CD cord-023134-y665agnh 391 7 remained remain VBD cord-023134-y665agnh 391 8 unchanged unchanged JJ cord-023134-y665agnh 391 9 . . . cord-023134-y665agnh 392 1 Five five CD cord-023134-y665agnh 392 2 paroxysmal paroxysmal JJ cord-023134-y665agnh 392 3 3AVBs 3AVBs NNP cord-023134-y665agnh 392 4 progressed progress VBD cord-023134-y665agnh 392 5 to to TO cord-023134-y665agnh 392 6 complete complete VB cord-023134-y665agnh 392 7 AVB AVB NNP cord-023134-y665agnh 392 8 , , , cord-023134-y665agnh 392 9 3 3 CD cord-023134-y665agnh 392 10 to to TO cord-023134-y665agnh 392 11 2:1 2:1 CD cord-023134-y665agnh 392 12 AVB AVB NNP cord-023134-y665agnh 392 13 and and CC cord-023134-y665agnh 392 14 3 3 CD cord-023134-y665agnh 392 15 remained remain VBD cord-023134-y665agnh 392 16 unchanged unchanged JJ cord-023134-y665agnh 392 17 . . . cord-023134-y665agnh 393 1 Four four CD cord-023134-y665agnh 393 2 2:1 2:1 CD cord-023134-y665agnh 393 3 AVBs avb NNS cord-023134-y665agnh 393 4 progressed progress VBD cord-023134-y665agnh 393 5 to to TO cord-023134-y665agnh 393 6 complete complete VB cord-023134-y665agnh 393 7 AVB AVB NNP cord-023134-y665agnh 393 8 , , , cord-023134-y665agnh 393 9 2 2 CD cord-023134-y665agnh 393 10 regressed regress VBD cord-023134-y665agnh 393 11 to to IN cord-023134-y665agnh 393 12 sinus sinus NN cord-023134-y665agnh 393 13 rhythm rhythm NN cord-023134-y665agnh 393 14 and and CC cord-023134-y665agnh 393 15 1 1 CD cord-023134-y665agnh 393 16 remained remain VBD cord-023134-y665agnh 393 17 unchanged unchanged JJ cord-023134-y665agnh 393 18 . . . cord-023134-y665agnh 394 1 All all DT cord-023134-y665agnh 394 2 AVBs avb NNS cord-023134-y665agnh 394 3 with with IN cord-023134-y665agnh 394 4 atrial atrial JJ cord-023134-y665agnh 394 5 fibrillation fibrillation NN cord-023134-y665agnh 394 6 remained remain VBD cord-023134-y665agnh 394 7 unchanged unchanged JJ cord-023134-y665agnh 394 8 . . . cord-023134-y665agnh 395 1 Chi Chi NNP cord-023134-y665agnh 395 2 - - HYPH cord-023134-y665agnh 395 3 square square JJ cord-023134-y665agnh 395 4 test test NN cord-023134-y665agnh 395 5 showed show VBD cord-023134-y665agnh 395 6 that that IN cord-023134-y665agnh 395 7 changes change NNS cord-023134-y665agnh 395 8 of of IN cord-023134-y665agnh 395 9 intrinsic intrinsic JJ cord-023134-y665agnh 395 10 rhythm rhythm NN cord-023134-y665agnh 395 11 were be VBD cord-023134-y665agnh 395 12 associated associate VBN cord-023134-y665agnh 395 13 with with IN cord-023134-y665agnh 395 14 the the DT cord-023134-y665agnh 395 15 type type NN cord-023134-y665agnh 395 16 of of IN cord-023134-y665agnh 395 17 AVB AVB NNP cord-023134-y665agnh 395 18 ( ( -LRB- cord-023134-y665agnh 395 19 v v NN cord-023134-y665agnh 395 20 2 2 CD cord-023134-y665agnh 395 21 4.5 4.5 CD cord-023134-y665agnh 395 22 , , , cord-023134-y665agnh 395 23 p<.03 p<.03 NNPS cord-023134-y665agnh 395 24 ) ) -RRB- cord-023134-y665agnh 395 25 and and CC cord-023134-y665agnh 395 26 the the DT cord-023134-y665agnh 395 27 time time NN cord-023134-y665agnh 395 28 of of IN cord-023134-y665agnh 395 29 controls control NNS cord-023134-y665agnh 395 30 ( ( -LRB- cord-023134-y665agnh 395 31 v v NN cord-023134-y665agnh 395 32 2 2 CD cord-023134-y665agnh 395 33 64.4 64.4 CD cord-023134-y665agnh 395 34 , , , cord-023134-y665agnh 395 35 p<.0001 p<.0001 CD cord-023134-y665agnh 395 36 ) ) -RRB- cord-023134-y665agnh 395 37 , , , cord-023134-y665agnh 395 38 while while IN cord-023134-y665agnh 395 39 other other JJ cord-023134-y665agnh 395 40 factors factor NNS cord-023134-y665agnh 395 41 were be VBD cord-023134-y665agnh 395 42 not not RB cord-023134-y665agnh 395 43 statistically statistically RB cord-023134-y665agnh 395 44 significant significant JJ cord-023134-y665agnh 395 45 . . . cord-023134-y665agnh 396 1 Regression regression NN cord-023134-y665agnh 396 2 occurred occur VBD cord-023134-y665agnh 396 3 within within IN cord-023134-y665agnh 396 4 30 30 CD cord-023134-y665agnh 396 5 days day NNS cord-023134-y665agnh 396 6 while while IN cord-023134-y665agnh 396 7 progression progression NN cord-023134-y665agnh 396 8 occurred occur VBD cord-023134-y665agnh 396 9 at at IN cord-023134-y665agnh 396 10 any any DT cord-023134-y665agnh 396 11 times time NNS cord-023134-y665agnh 396 12 . . . cord-023134-y665agnh 397 1 The the DT cord-023134-y665agnh 397 2 results result NNS cord-023134-y665agnh 397 3 showed show VBD cord-023134-y665agnh 397 4 that that IN cord-023134-y665agnh 397 5 the the DT cord-023134-y665agnh 397 6 degree degree NN cord-023134-y665agnh 397 7 of of IN cord-023134-y665agnh 397 8 AVB AVB NNP cord-023134-y665agnh 397 9 at at IN cord-023134-y665agnh 397 10 the the DT cord-023134-y665agnh 397 11 moment moment NN cord-023134-y665agnh 397 12 of of IN cord-023134-y665agnh 397 13 PM PM NNP cord-023134-y665agnh 397 14 implantion implantion NN cord-023134-y665agnh 397 15 should should MD cord-023134-y665agnh 397 16 not not RB cord-023134-y665agnh 397 17 be be VB cord-023134-y665agnh 397 18 considered consider VBN cord-023134-y665agnh 397 19 a a DT cord-023134-y665agnh 397 20 definitive definitive JJ cord-023134-y665agnh 397 21 diagnosis diagnosis NN cord-023134-y665agnh 397 22 since since IN cord-023134-y665agnh 397 23 more more JJR cord-023134-y665agnh 397 24 than than IN cord-023134-y665agnh 397 25 1/3 1/3 CD cord-023134-y665agnh 397 26 of of IN cord-023134-y665agnh 397 27 the the DT cord-023134-y665agnh 397 28 cases case NNS cord-023134-y665agnh 397 29 could could MD cord-023134-y665agnh 397 30 present present VB cord-023134-y665agnh 397 31 progression progression NN cord-023134-y665agnh 397 32 or or CC cord-023134-y665agnh 397 33 regression regression NN cord-023134-y665agnh 397 34 . . . cord-023134-y665agnh 398 1 Because because IN cord-023134-y665agnh 398 2 of of IN cord-023134-y665agnh 398 3 their -PRON- PRP$ cord-023134-y665agnh 398 4 potential potential JJ cord-023134-y665agnh 398 5 progression progression NN cord-023134-y665agnh 398 6 , , , cord-023134-y665agnh 398 7 PM pm NN cord-023134-y665agnh 398 8 implantation implantation NN cord-023134-y665agnh 398 9 should should MD cord-023134-y665agnh 398 10 be be VB cord-023134-y665agnh 398 11 considered consider VBN cord-023134-y665agnh 398 12 as as IN cord-023134-y665agnh 398 13 first first JJ cord-023134-y665agnh 398 14 choice choice NN cord-023134-y665agnh 398 15 treatment treatment NN cord-023134-y665agnh 398 16 also also RB cord-023134-y665agnh 398 17 in in IN cord-023134-y665agnh 398 18 cases case NNS cord-023134-y665agnh 398 19 of of IN cord-023134-y665agnh 398 20 low low JJ cord-023134-y665agnh 398 21 2AVBs 2avbs NN cord-023134-y665agnh 398 22 , , , cord-023134-y665agnh 398 23 and and CC cord-023134-y665agnh 398 24 further further JJ cord-023134-y665agnh 398 25 studies study NNS cord-023134-y665agnh 398 26 are be VBP cord-023134-y665agnh 398 27 needed need VBN cord-023134-y665agnh 398 28 to to TO cord-023134-y665agnh 398 29 evaluate evaluate VB cord-023134-y665agnh 398 30 the the DT cord-023134-y665agnh 398 31 cause cause NN cord-023134-y665agnh 398 32 of of IN cord-023134-y665agnh 398 33 transitory transitory JJ cord-023134-y665agnh 398 34 high high JJ cord-023134-y665agnh 398 35 grade grade NN cord-023134-y665agnh 398 36 AVBs avb NNS cord-023134-y665agnh 398 37 . . . cord-023134-y665agnh 399 1 Tissue tissue NN cord-023134-y665agnh 399 2 Doppler Doppler NNP cord-023134-y665agnh 399 3 Imaging Imaging NNP cord-023134-y665agnh 399 4 ( ( -LRB- cord-023134-y665agnh 399 5 TDI TDI NNP cord-023134-y665agnh 399 6 ) ) -RRB- cord-023134-y665agnh 399 7 is be VBZ cord-023134-y665agnh 399 8 a a DT cord-023134-y665agnh 399 9 complement complement NN cord-023134-y665agnh 399 10 to to IN cord-023134-y665agnh 399 11 conventional conventional JJ cord-023134-y665agnh 399 12 echocardiography echocardiography NN cord-023134-y665agnh 399 13 for for IN cord-023134-y665agnh 399 14 assessment assessment NN cord-023134-y665agnh 399 15 of of IN cord-023134-y665agnh 399 16 myocardial myocardial JJ cord-023134-y665agnh 399 17 function function NN cord-023134-y665agnh 399 18 . . . cord-023134-y665agnh 400 1 The the DT cord-023134-y665agnh 400 2 aims aim NNS cord-023134-y665agnh 400 3 of of IN cord-023134-y665agnh 400 4 the the DT cord-023134-y665agnh 400 5 study study NN cord-023134-y665agnh 400 6 were be VBD cord-023134-y665agnh 400 7 to to TO cord-023134-y665agnh 400 8 investigate investigate VB cord-023134-y665agnh 400 9 breed breed NN cord-023134-y665agnh 400 10 differences difference NNS cord-023134-y665agnh 400 11 and and CC cord-023134-y665agnh 400 12 intraobserver intraobserver NN cord-023134-y665agnh 400 13 - - HYPH cord-023134-y665agnh 400 14 variability variability NN cord-023134-y665agnh 400 15 of of IN cord-023134-y665agnh 400 16 colour colour NN cord-023134-y665agnh 400 17 TDI tdi NN cord-023134-y665agnh 400 18 variables variable NNS cord-023134-y665agnh 400 19 in in IN cord-023134-y665agnh 400 20 healthy healthy JJ cord-023134-y665agnh 400 21 dogs dog NNS cord-023134-y665agnh 400 22 . . . cord-023134-y665agnh 401 1 Fifty fifty CD cord-023134-y665agnh 401 2 - - HYPH cord-023134-y665agnh 401 3 three three CD cord-023134-y665agnh 401 4 privately privately RB cord-023134-y665agnh 401 5 - - HYPH cord-023134-y665agnh 401 6 owned own VBN cord-023134-y665agnh 401 7 male male JJ cord-023134-y665agnh 401 8 dogs dog NNS cord-023134-y665agnh 401 9 were be VBD cord-023134-y665agnh 401 10 prospectively prospectively RB cord-023134-y665agnh 401 11 recruited recruit VBN cord-023134-y665agnh 401 12 . . . cord-023134-y665agnh 402 1 Dogs dog NNS cord-023134-y665agnh 402 2 were be VBD cord-023134-y665agnh 402 3 declared declare VBN cord-023134-y665agnh 402 4 healthy healthy JJ cord-023134-y665agnh 402 5 by by IN cord-023134-y665agnh 402 6 physical physical JJ cord-023134-y665agnh 402 7 examination examination NN cord-023134-y665agnh 402 8 , , , cord-023134-y665agnh 402 9 blood blood NN cord-023134-y665agnh 402 10 pressure pressure NN cord-023134-y665agnh 402 11 measurement measurement NN cord-023134-y665agnh 402 12 , , , cord-023134-y665agnh 402 13 ECG ECG NNP cord-023134-y665agnh 402 14 , , , cord-023134-y665agnh 402 15 analyses analysis NNS cord-023134-y665agnh 402 16 of of IN cord-023134-y665agnh 402 17 urine urine NN cord-023134-y665agnh 402 18 and and CC cord-023134-y665agnh 402 19 blood blood NN cord-023134-y665agnh 402 20 ( ( -LRB- cord-023134-y665agnh 402 21 haematology haematology NN cord-023134-y665agnh 402 22 and and CC cord-023134-y665agnh 402 23 biochemistry biochemistry NN cord-023134-y665agnh 402 24 ) ) -RRB- cord-023134-y665agnh 402 25 , , , cord-023134-y665agnh 402 26 and and CC cord-023134-y665agnh 402 27 conventional conventional JJ cord-023134-y665agnh 402 28 echocardiographic echocardiographic NNP cord-023134-y665agnh 402 29 2D 2D NNP cord-023134-y665agnh 402 30 and and CC cord-023134-y665agnh 402 31 Doppler Doppler NNP cord-023134-y665agnh 402 32 examination examination NN cord-023134-y665agnh 402 33 , , , cord-023134-y665agnh 402 34 as as IN cord-023134-y665agnh 402 35 part part NN cord-023134-y665agnh 402 36 of of IN cord-023134-y665agnh 402 37 the the DT cord-023134-y665agnh 402 38 EU EU NNP cord-023134-y665agnh 402 39 - - HYPH cord-023134-y665agnh 402 40 funded fund VBN cord-023134-y665agnh 402 41 Lupa Lupa NNP cord-023134-y665agnh 402 42 - - HYPH cord-023134-y665agnh 402 43 project project NN cord-023134-y665agnh 402 44 . . . cord-023134-y665agnh 403 1 Directly directly RB cord-023134-y665agnh 403 2 following follow VBG cord-023134-y665agnh 403 3 these these DT cord-023134-y665agnh 403 4 extensive extensive JJ cord-023134-y665agnh 403 5 examinations examination NNS cord-023134-y665agnh 403 6 , , , cord-023134-y665agnh 403 7 the the DT cord-023134-y665agnh 403 8 TDI TDI NNP cord-023134-y665agnh 403 9 acquisition acquisition NN cord-023134-y665agnh 403 10 was be VBD cord-023134-y665agnh 403 11 performed perform VBN cord-023134-y665agnh 403 12 by by IN cord-023134-y665agnh 403 13 the the DT cord-023134-y665agnh 403 14 same same JJ cord-023134-y665agnh 403 15 experienced experienced JJ cord-023134-y665agnh 403 16 echocardiographer echocardiographer NNPS cord-023134-y665agnh 403 17 using use VBG cord-023134-y665agnh 403 18 a a DT cord-023134-y665agnh 403 19 Philips Philips NNP cord-023134-y665agnh 403 20 HD11xe HD11xe NNP cord-023134-y665agnh 403 21 with with IN cord-023134-y665agnh 403 22 a a DT cord-023134-y665agnh 403 23 S8 S8 NNP cord-023134-y665agnh 403 24 - - HYPH cord-023134-y665agnh 403 25 3 3 CD cord-023134-y665agnh 403 26 ( ( -LRB- cord-023134-y665agnh 403 27 small small JJ cord-023134-y665agnh 403 28 dogs dog NNS cord-023134-y665agnh 403 29 ) ) -RRB- cord-023134-y665agnh 403 30 and and CC cord-023134-y665agnh 403 31 S3 S3 NNP cord-023134-y665agnh 403 32 - - HYPH cord-023134-y665agnh 403 33 1 1 NNP cord-023134-y665agnh 403 34 ( ( -LRB- cord-023134-y665agnh 403 35 large large JJ cord-023134-y665agnh 403 36 dogs dog NNS cord-023134-y665agnh 403 37 ) ) -RRB- cord-023134-y665agnh 403 38 MHz MHz NNPS cord-023134-y665agnh 403 39 probe probe VBP cord-023134-y665agnh 403 40 . . . cord-023134-y665agnh 404 1 Cineloops Cineloops NNP cord-023134-y665agnh 404 2 were be VBD cord-023134-y665agnh 404 3 acquired acquire VBN cord-023134-y665agnh 404 4 from from IN cord-023134-y665agnh 404 5 the the DT cord-023134-y665agnh 404 6 right right JJ cord-023134-y665agnh 404 7 short short JJ cord-023134-y665agnh 404 8 - - HYPH cord-023134-y665agnh 404 9 axis axis NN cord-023134-y665agnh 404 10 view view NN cord-023134-y665agnh 404 11 and and CC cord-023134-y665agnh 404 12 radial radial JJ cord-023134-y665agnh 404 13 colour colour NN cord-023134-y665agnh 404 14 TDI tdi NN cord-023134-y665agnh 404 15 variables variable NNS cord-023134-y665agnh 404 16 at at IN cord-023134-y665agnh 404 17 the the DT cord-023134-y665agnh 404 18 endocardium endocardium NN cord-023134-y665agnh 404 19 and and CC cord-023134-y665agnh 404 20 epicardium epicardium NN cord-023134-y665agnh 404 21 of of IN cord-023134-y665agnh 404 22 the the DT cord-023134-y665agnh 404 23 left left JJ cord-023134-y665agnh 404 24 ventricular ventricular JJ cord-023134-y665agnh 404 25 free free JJ cord-023134-y665agnh 404 26 wall wall NN cord-023134-y665agnh 404 27 were be VBD cord-023134-y665agnh 404 28 later later RB cord-023134-y665agnh 404 29 analysed analyse VBN cord-023134-y665agnh 404 30 . . . cord-023134-y665agnh 405 1 Six six CD cord-023134-y665agnh 405 2 other other JJ cord-023134-y665agnh 405 3 healthy healthy JJ cord-023134-y665agnh 405 4 dogs dog NNS cord-023134-y665agnh 405 5 were be VBD cord-023134-y665agnh 405 6 included include VBN cord-023134-y665agnh 405 7 in in IN cord-023134-y665agnh 405 8 a a DT cord-023134-y665agnh 405 9 substudy substudy NN cord-023134-y665agnh 405 10 aimed aim VBN cord-023134-y665agnh 405 11 at at IN cord-023134-y665agnh 405 12 evaluating evaluate VBG cord-023134-y665agnh 405 13 the the DT cord-023134-y665agnh 405 14 effect effect NN cord-023134-y665agnh 405 15 of of IN cord-023134-y665agnh 405 16 6 6 CD cord-023134-y665agnh 405 17 sources source NNS cord-023134-y665agnh 405 18 of of IN cord-023134-y665agnh 405 19 variation variation NN cord-023134-y665agnh 405 20 using use VBG cord-023134-y665agnh 405 21 a a DT cord-023134-y665agnh 405 22 hierarchial hierarchial JJ cord-023134-y665agnh 405 23 random random JJ cord-023134-y665agnh 405 24 - - HYPH cord-023134-y665agnh 405 25 effects effect NNS cord-023134-y665agnh 405 26 model model NN cord-023134-y665agnh 405 27 . . . cord-023134-y665agnh 406 1 Ten ten CD cord-023134-y665agnh 406 2 of of IN cord-023134-y665agnh 406 3 the the DT cord-023134-y665agnh 406 4 53 53 CD cord-023134-y665agnh 406 5 examined examine VBN cord-023134-y665agnh 406 6 dogs dog NNS cord-023134-y665agnh 406 7 were be VBD cord-023134-y665agnh 406 8 excluded exclude VBN cord-023134-y665agnh 406 9 due due IN cord-023134-y665agnh 406 10 to to IN cord-023134-y665agnh 406 11 breathing breathing NN cord-023134-y665agnh 406 12 artifacts artifact NNS cord-023134-y665agnh 406 13 and and CC cord-023134-y665agnh 406 14 poor poor JJ cord-023134-y665agnh 406 15 quality quality NN cord-023134-y665agnh 406 16 of of IN cord-023134-y665agnh 406 17 the the DT cord-023134-y665agnh 406 18 curves curve NNS cord-023134-y665agnh 406 19 , , , cord-023134-y665agnh 406 20 leaving leave VBG cord-023134-y665agnh 406 21 43 43 CD cord-023134-y665agnh 406 22 dogs dog NNS cord-023134-y665agnh 406 23 in in IN cord-023134-y665agnh 406 24 the the DT cord-023134-y665agnh 406 25 study study NN cord-023134-y665agnh 406 26 ; ; : cord-023134-y665agnh 406 27 Labrador Labrador NNP cord-023134-y665agnh 406 28 retrievers retriever NNS cord-023134-y665agnh 406 29 ( ( -LRB- cord-023134-y665agnh 406 30 19 19 CD cord-023134-y665agnh 406 31 ) ) -RRB- cord-023134-y665agnh 406 32 , , , cord-023134-y665agnh 406 33 Cavalier Cavalier NNP cord-023134-y665agnh 406 34 King King NNP cord-023134-y665agnh 406 35 Charles Charles NNP cord-023134-y665agnh 406 36 spaniels spaniel NNS cord-023134-y665agnh 406 37 ( ( -LRB- cord-023134-y665agnh 406 38 19 19 CD cord-023134-y665agnh 406 39 ) ) -RRB- cord-023134-y665agnh 406 40 , , , cord-023134-y665agnh 406 41 and and CC cord-023134-y665agnh 406 42 Dachshunds Dachshunds NNPS cord-023134-y665agnh 406 43 ( ( -LRB- cord-023134-y665agnh 406 44 5 5 CD cord-023134-y665agnh 406 45 ) ) -RRB- cord-023134-y665agnh 406 46 , , , cord-023134-y665agnh 406 47 with with IN cord-023134-y665agnh 406 48 a a DT cord-023134-y665agnh 406 49 mean mean JJ cord-023134-y665agnh 406 50 age age NN cord-023134-y665agnh 406 51 of of IN cord-023134-y665agnh 406 52 3.4 3.4 CD cord-023134-y665agnh 406 53 ± ± CD cord-023134-y665agnh 406 54 1.2 1.2 CD cord-023134-y665agnh 406 55 years year NNS cord-023134-y665agnh 406 56 ( ( -LRB- cord-023134-y665agnh 406 57 SD SD NNP cord-023134-y665agnh 406 58 ) ) -RRB- cord-023134-y665agnh 406 59 . . . cord-023134-y665agnh 407 1 A a DT cord-023134-y665agnh 407 2 P p NN cord-023134-y665agnh 407 3 - - HYPH cord-023134-y665agnh 407 4 value value NN cord-023134-y665agnh 407 5 < < XX cord-023134-y665agnh 407 6 0.05 0.05 CD cord-023134-y665agnh 407 7 was be VBD cord-023134-y665agnh 407 8 considered consider VBN cord-023134-y665agnh 407 9 significant significant JJ cord-023134-y665agnh 407 10 in in IN cord-023134-y665agnh 407 11 the the DT cord-023134-y665agnh 407 12 statistical statistical JJ cord-023134-y665agnh 407 13 analyses analysis NNS cord-023134-y665agnh 407 14 . . . cord-023134-y665agnh 408 1 Kruskal Kruskal NNP cord-023134-y665agnh 408 2 - - HYPH cord-023134-y665agnh 408 3 Wallis Wallis NNP cord-023134-y665agnh 408 4 one one CD cord-023134-y665agnh 408 5 - - HYPH cord-023134-y665agnh 408 6 way way NN cord-023134-y665agnh 408 7 analysis analysis NN cord-023134-y665agnh 408 8 of of IN cord-023134-y665agnh 408 9 variance variance NN cord-023134-y665agnh 408 10 showed show VBD cord-023134-y665agnh 408 11 that that IN cord-023134-y665agnh 408 12 Labrador Labrador NNP cord-023134-y665agnh 408 13 retrievers retriever NNS cord-023134-y665agnh 408 14 had have VBD cord-023134-y665agnh 408 15 significantly significantly RB cord-023134-y665agnh 408 16 higher high JJR cord-023134-y665agnh 408 17 values value NNS cord-023134-y665agnh 408 18 for for IN cord-023134-y665agnh 408 19 endocardial endocardial JJ cord-023134-y665agnh 408 20 and and CC cord-023134-y665agnh 408 21 epicardial epicardial VB cord-023134-y665agnh 408 22 systolic systolic JJ cord-023134-y665agnh 408 23 ( ( -LRB- cord-023134-y665agnh 408 24 S s NN cord-023134-y665agnh 408 25 ) ) -RRB- cord-023134-y665agnh 408 26 waves wave NNS cord-023134-y665agnh 408 27 , , , cord-023134-y665agnh 408 28 and and CC cord-023134-y665agnh 408 29 longer long JJR cord-023134-y665agnh 408 30 time time NN cord-023134-y665agnh 408 31 to to TO cord-023134-y665agnh 408 32 peak peak VB cord-023134-y665agnh 408 33 for for IN cord-023134-y665agnh 408 34 both both DT cord-023134-y665agnh 408 35 endocardial endocardial JJ cord-023134-y665agnh 408 36 and and CC cord-023134-y665agnh 408 37 epicardial epicardial NNP cord-023134-y665agnh 408 38 E e NN cord-023134-y665agnh 408 39 - - : cord-023134-y665agnh 408 40 and and CC cord-023134-y665agnh 408 41 A A NNP cord-023134-y665agnh 408 42 - - HYPH cord-023134-y665agnh 408 43 waves wave NNS cord-023134-y665agnh 408 44 , , , cord-023134-y665agnh 408 45 compared compare VBN cord-023134-y665agnh 408 46 to to IN cord-023134-y665agnh 408 47 the the DT cord-023134-y665agnh 408 48 other other JJ cord-023134-y665agnh 408 49 two two CD cord-023134-y665agnh 408 50 breeds breed NNS cord-023134-y665agnh 408 51 . . . cord-023134-y665agnh 409 1 Labrador Labrador NNP cord-023134-y665agnh 409 2 retrievers retriever NNS cord-023134-y665agnh 409 3 also also RB cord-023134-y665agnh 409 4 had have VBD cord-023134-y665agnh 409 5 significantly significantly RB cord-023134-y665agnh 409 6 lower low JJR cord-023134-y665agnh 409 7 heart heart NN cord-023134-y665agnh 409 8 rate rate NN cord-023134-y665agnh 409 9 ( ( -LRB- cord-023134-y665agnh 409 10 HR HR NNP cord-023134-y665agnh 409 11 ) ) -RRB- cord-023134-y665agnh 409 12 . . . cord-023134-y665agnh 410 1 Further further JJ cord-023134-y665agnh 410 2 analysis analysis NN cord-023134-y665agnh 410 3 of of IN cord-023134-y665agnh 410 4 the the DT cord-023134-y665agnh 410 5 breed breed NN cord-023134-y665agnh 410 6 differences difference NNS cord-023134-y665agnh 410 7 using use VBG cord-023134-y665agnh 410 8 multiple multiple JJ cord-023134-y665agnh 410 9 regression regression NN cord-023134-y665agnh 410 10 analysis analysis NN cord-023134-y665agnh 410 11 showed show VBD cord-023134-y665agnh 410 12 major major JJ cord-023134-y665agnh 410 13 effects effect NNS cord-023134-y665agnh 410 14 of of IN cord-023134-y665agnh 410 15 body body NN cord-023134-y665agnh 410 16 weight weight NN cord-023134-y665agnh 410 17 and and CC cord-023134-y665agnh 410 18 HR hr NN cord-023134-y665agnh 410 19 on on IN cord-023134-y665agnh 410 20 endocardial endocardial JJ cord-023134-y665agnh 410 21 and and CC cord-023134-y665agnh 410 22 epicardial epicardial NNP cord-023134-y665agnh 410 23 S s NN cord-023134-y665agnh 410 24 waves wave NNS cord-023134-y665agnh 410 25 , , , cord-023134-y665agnh 410 26 while while IN cord-023134-y665agnh 410 27 time time NN cord-023134-y665agnh 410 28 to to TO cord-023134-y665agnh 410 29 peak peak VB cord-023134-y665agnh 410 30 , , , cord-023134-y665agnh 410 31 both both DT cord-023134-y665agnh 410 32 endocardial endocardial JJ cord-023134-y665agnh 410 33 and and CC cord-023134-y665agnh 410 34 epicardial epicardial NNP cord-023134-y665agnh 410 35 , , , cord-023134-y665agnh 410 36 for for IN cord-023134-y665agnh 410 37 the the DT cord-023134-y665agnh 410 38 E e NN cord-023134-y665agnh 410 39 - - : cord-023134-y665agnh 410 40 and and CC cord-023134-y665agnh 410 41 A A NNP cord-023134-y665agnh 410 42 - - HYPH cord-023134-y665agnh 410 43 waves wave NNS cord-023134-y665agnh 410 44 , , , cord-023134-y665agnh 410 45 were be VBD cord-023134-y665agnh 410 46 primarily primarily RB cord-023134-y665agnh 410 47 affected affect VBN cord-023134-y665agnh 410 48 by by IN cord-023134-y665agnh 410 49 HR HR NNP cord-023134-y665agnh 410 50 . . . cord-023134-y665agnh 411 1 Dog Dog NNP cord-023134-y665agnh 411 2 was be VBD cord-023134-y665agnh 411 3 the the DT cord-023134-y665agnh 411 4 variance variance NN cord-023134-y665agnh 411 5 component component NN cord-023134-y665agnh 411 6 having have VBG cord-023134-y665agnh 411 7 the the DT cord-023134-y665agnh 411 8 major major JJ cord-023134-y665agnh 411 9 effect effect NN cord-023134-y665agnh 411 10 on on IN cord-023134-y665agnh 411 11 variability variability NN cord-023134-y665agnh 411 12 of of IN cord-023134-y665agnh 411 13 TDI TDI NNP cord-023134-y665agnh 411 14 variables variable NNS cord-023134-y665agnh 411 15 . . . cord-023134-y665agnh 412 1 In in IN cord-023134-y665agnh 412 2 conclusion conclusion NN cord-023134-y665agnh 412 3 , , , cord-023134-y665agnh 412 4 time time NN cord-023134-y665agnh 412 5 to to TO cord-023134-y665agnh 412 6 peak peak VB cord-023134-y665agnh 412 7 of of IN cord-023134-y665agnh 412 8 both both DT cord-023134-y665agnh 412 9 diastolic diastolic JJ cord-023134-y665agnh 412 10 waves wave NNS cord-023134-y665agnh 412 11 was be VBD cord-023134-y665agnh 412 12 longer long JJR cord-023134-y665agnh 412 13 in in IN cord-023134-y665agnh 412 14 Labrador Labrador NNP cord-023134-y665agnh 412 15 retrievers retriever NNS cord-023134-y665agnh 412 16 compared compare VBN cord-023134-y665agnh 412 17 to to IN cord-023134-y665agnh 412 18 the the DT cord-023134-y665agnh 412 19 small small JJ cord-023134-y665agnh 412 20 - - HYPH cord-023134-y665agnh 412 21 breed breed NN cord-023134-y665agnh 412 22 dogs dog NNS cord-023134-y665agnh 412 23 . . . cord-023134-y665agnh 413 1 Furthermore furthermore RB cord-023134-y665agnh 413 2 , , , cord-023134-y665agnh 413 3 higher high JJR cord-023134-y665agnh 413 4 S s NN cord-023134-y665agnh 413 5 - - HYPH cord-023134-y665agnh 413 6 wave wave NN cord-023134-y665agnh 413 7 values value NNS cord-023134-y665agnh 413 8 in in IN cord-023134-y665agnh 413 9 Labrador Labrador NNP cord-023134-y665agnh 413 10 retrievers retriever NNS cord-023134-y665agnh 413 11 might may MD cord-023134-y665agnh 413 12 indicate indicate VB cord-023134-y665agnh 413 13 a a DT cord-023134-y665agnh 413 14 different different JJ cord-023134-y665agnh 413 15 contractility contractility NN cord-023134-y665agnh 413 16 pattern pattern NN cord-023134-y665agnh 413 17 in in IN cord-023134-y665agnh 413 18 largebreed largebreed NN cord-023134-y665agnh 413 19 dogs dog NNS cord-023134-y665agnh 413 20 , , , cord-023134-y665agnh 413 21 and and CC cord-023134-y665agnh 413 22 warrants warrant NNS cord-023134-y665agnh 413 23 further further JJ cord-023134-y665agnh 413 24 investigation investigation NN cord-023134-y665agnh 413 25 . . . cord-023134-y665agnh 414 1 Mitral mitral JJ cord-023134-y665agnh 414 2 regurgitation regurgitation NN cord-023134-y665agnh 414 3 ( ( -LRB- cord-023134-y665agnh 414 4 MR MR NNP cord-023134-y665agnh 414 5 ) ) -RRB- cord-023134-y665agnh 414 6 is be VBZ cord-023134-y665agnh 414 7 the the DT cord-023134-y665agnh 414 8 most most RBS cord-023134-y665agnh 414 9 common common JJ cord-023134-y665agnh 414 10 heart heart NN cord-023134-y665agnh 414 11 disease disease NN cord-023134-y665agnh 414 12 in in IN cord-023134-y665agnh 414 13 dogs dog NNS cord-023134-y665agnh 414 14 . . . cord-023134-y665agnh 415 1 Dogs dog NNS cord-023134-y665agnh 415 2 with with IN cord-023134-y665agnh 415 3 a a DT cord-023134-y665agnh 415 4 more more RBR cord-023134-y665agnh 415 5 advanced advanced JJ cord-023134-y665agnh 415 6 stage stage NN cord-023134-y665agnh 415 7 of of IN cord-023134-y665agnh 415 8 this this DT cord-023134-y665agnh 415 9 disease disease NN cord-023134-y665agnh 415 10 are be VBP cord-023134-y665agnh 415 11 likely likely JJ cord-023134-y665agnh 415 12 to to TO cord-023134-y665agnh 415 13 develop develop VB cord-023134-y665agnh 415 14 pulmonary pulmonary JJ cord-023134-y665agnh 415 15 edema edema NN cord-023134-y665agnh 415 16 of of IN cord-023134-y665agnh 415 17 heart heart NN cord-023134-y665agnh 415 18 failure failure NN cord-023134-y665agnh 415 19 . . . cord-023134-y665agnh 416 1 The the DT cord-023134-y665agnh 416 2 aim aim NN cord-023134-y665agnh 416 3 of of IN cord-023134-y665agnh 416 4 this this DT cord-023134-y665agnh 416 5 study study NN cord-023134-y665agnh 416 6 was be VBD cord-023134-y665agnh 416 7 to to TO cord-023134-y665agnh 416 8 evaluate evaluate VB cord-023134-y665agnh 416 9 the the DT cord-023134-y665agnh 416 10 plasma plasma NN cord-023134-y665agnh 416 11 C c NN cord-023134-y665agnh 416 12 - - HYPH cord-023134-y665agnh 416 13 reactive reactive JJ cord-023134-y665agnh 416 14 protein protein NN cord-023134-y665agnh 416 15 ( ( -LRB- cord-023134-y665agnh 416 16 CRP CRP NNP cord-023134-y665agnh 416 17 ) ) -RRB- cord-023134-y665agnh 416 18 concentra concentra NNP cord-023134-y665agnh 416 19 - - HYPH cord-023134-y665agnh 416 20 tion tion NN cord-023134-y665agnh 416 21 in in IN cord-023134-y665agnh 416 22 dogs dog NNS cord-023134-y665agnh 416 23 that that WDT cord-023134-y665agnh 416 24 underwent undergo VBD cord-023134-y665agnh 416 25 mitral mitral JJ cord-023134-y665agnh 416 26 valve valve NN cord-023134-y665agnh 416 27 repair repair NN cord-023134-y665agnh 416 28 for for IN cord-023134-y665agnh 416 29 MR.All MR.All NNP cord-023134-y665agnh 416 30 dogs dog NNS cord-023134-y665agnh 416 31 were be VBD cord-023134-y665agnh 416 32 operated operate VBN cord-023134-y665agnh 416 33 between between IN cord-023134-y665agnh 416 34 October October NNP cord-023134-y665agnh 416 35 2006 2006 CD cord-023134-y665agnh 416 36 and and CC cord-023134-y665agnh 416 37 October October NNP cord-023134-y665agnh 416 38 2010 2010 CD cord-023134-y665agnh 416 39 . . . cord-023134-y665agnh 417 1 The the DT cord-023134-y665agnh 417 2 dogs dog NNS cord-023134-y665agnh 417 3 were be VBD cord-023134-y665agnh 417 4 categorized categorize VBN cord-023134-y665agnh 417 5 according accord VBG cord-023134-y665agnh 417 6 to to IN cord-023134-y665agnh 417 7 the the DT cord-023134-y665agnh 417 8 International International NNP cord-023134-y665agnh 417 9 Small Small NNP cord-023134-y665agnh 417 10 Animal Animal NNP cord-023134-y665agnh 417 11 Cardiac Cardiac NNP cord-023134-y665agnh 417 12 Health Health NNP cord-023134-y665agnh 417 13 Council Council NNP cord-023134-y665agnh 417 14 ( ( -LRB- cord-023134-y665agnh 417 15 ISACHC ISACHC NNP cord-023134-y665agnh 417 16 ) ) -RRB- cord-023134-y665agnh 417 17 classification classification NN cord-023134-y665agnh 417 18 , , , cord-023134-y665agnh 417 19 and and CC cord-023134-y665agnh 417 20 physical physical JJ cord-023134-y665agnh 417 21 examination examination NN cord-023134-y665agnh 417 22 , , , cord-023134-y665agnh 417 23 thoracic thoracic JJ cord-023134-y665agnh 417 24 radiography radiography NN cord-023134-y665agnh 417 25 , , , cord-023134-y665agnh 417 26 and and CC cord-023134-y665agnh 417 27 2D 2d NN cord-023134-y665agnh 417 28 color color NN cord-023134-y665agnh 417 29 flow flow NN cord-023134-y665agnh 417 30 Doppler Doppler NNP cord-023134-y665agnh 417 31 echocardiography echocardiography NN cord-023134-y665agnh 417 32 were be VBD cord-023134-y665agnh 417 33 performed perform VBN cord-023134-y665agnh 417 34 before before IN cord-023134-y665agnh 417 35 and and CC cord-023134-y665agnh 417 36 after after IN cord-023134-y665agnh 417 37 surgery surgery NN cord-023134-y665agnh 417 38 . . . cord-023134-y665agnh 418 1 The the DT cord-023134-y665agnh 418 2 plasma plasma NN cord-023134-y665agnh 418 3 CRP crp NN cord-023134-y665agnh 418 4 concentration concentration NN cord-023134-y665agnh 418 5 and and CC cord-023134-y665agnh 418 6 white white JJ cord-023134-y665agnh 418 7 blood blood NN cord-023134-y665agnh 418 8 cell cell NN cord-023134-y665agnh 418 9 counts count NNS cord-023134-y665agnh 418 10 were be VBD cord-023134-y665agnh 418 11 also also RB cord-023134-y665agnh 418 12 determined determine VBN cord-023134-y665agnh 418 13 before before IN cord-023134-y665agnh 418 14 and and CC cord-023134-y665agnh 418 15 after after IN cord-023134-y665agnh 418 16 surgery surgery NN cord-023134-y665agnh 418 17 . . . cord-023134-y665agnh 419 1 Cardiogenic cardiogenic JJ cord-023134-y665agnh 419 2 pulmonary pulmonary JJ cord-023134-y665agnh 419 3 edema edema NN cord-023134-y665agnh 419 4 was be VBD cord-023134-y665agnh 419 5 diagnosed diagnose VBN cord-023134-y665agnh 419 6 on on IN cord-023134-y665agnh 419 7 the the DT cord-023134-y665agnh 419 8 basis basis NN cord-023134-y665agnh 419 9 of of IN cord-023134-y665agnh 419 10 clinical clinical JJ cord-023134-y665agnh 419 11 examination examination NN cord-023134-y665agnh 419 12 and and CC cord-023134-y665agnh 419 13 thoracic thoracic JJ cord-023134-y665agnh 419 14 radiography radiography NN cord-023134-y665agnh 419 15 . . . cord-023134-y665agnh 420 1 Overall overall RB cord-023134-y665agnh 420 2 , , , cord-023134-y665agnh 420 3 44 44 CD cord-023134-y665agnh 420 4 dogs dog NNS cord-023134-y665agnh 420 5 ( ( -LRB- cord-023134-y665agnh 420 6 mean mean VB cord-023134-y665agnh 420 7 body body NN cord-023134-y665agnh 420 8 weight weight NN cord-023134-y665agnh 420 9 , , , cord-023134-y665agnh 420 10 5.6 5.6 CD cord-023134-y665agnh 420 11 ± ± NNP cord-023134-y665agnh 420 12 3.1 3.1 CD cord-023134-y665agnh 420 13 kg kg NNS cord-023134-y665agnh 420 14 and and CC cord-023134-y665agnh 420 15 mean mean VB cord-023134-y665agnh 420 16 age age NN cord-023134-y665agnh 420 17 , , , cord-023134-y665agnh 420 18 9.3 9.3 CD cord-023134-y665agnh 420 19 ± ± CD cord-023134-y665agnh 420 20 2.2 2.2 CD cord-023134-y665agnh 420 21 years year NNS cord-023134-y665agnh 420 22 ) ) -RRB- cord-023134-y665agnh 420 23 were be VBD cord-023134-y665agnh 420 24 enrolled enrol VBN cord-023134-y665agnh 420 25 ; ; : cord-023134-y665agnh 420 26 11 11 CD cord-023134-y665agnh 420 27 of of IN cord-023134-y665agnh 420 28 these these DT cord-023134-y665agnh 420 29 dogs dog NNS cord-023134-y665agnh 420 30 had have VBD cord-023134-y665agnh 420 31 cardiogenic cardiogenic JJ cord-023134-y665agnh 420 32 pulmonary pulmonary JJ cord-023134-y665agnh 420 33 edema edema NN cord-023134-y665agnh 420 34 . . . cord-023134-y665agnh 421 1 The the DT cord-023134-y665agnh 421 2 dogs dog NNS cord-023134-y665agnh 421 3 breeds breed NNS cord-023134-y665agnh 421 4 were be VBD cord-023134-y665agnh 421 5 Chihuahua Chihuahua NNP cord-023134-y665agnh 421 6 ( ( -LRB- cord-023134-y665agnh 421 7 n n NN cord-023134-y665agnh 421 8 = = SYM cord-023134-y665agnh 421 9 10 10 CD cord-023134-y665agnh 421 10 ) ) -RRB- cord-023134-y665agnh 421 11 , , , cord-023134-y665agnh 421 12 Cavalier Cavalier NNP cord-023134-y665agnh 421 13 King King NNP cord-023134-y665agnh 421 14 Charles Charles NNP cord-023134-y665agnh 421 15 Spaniel Spaniel NNP cord-023134-y665agnh 421 16 ( ( -LRB- cord-023134-y665agnh 421 17 n n NN cord-023134-y665agnh 421 18 = = SYM cord-023134-y665agnh 421 19 10 10 CD cord-023134-y665agnh 421 20 ) ) -RRB- cord-023134-y665agnh 421 21 , , , cord-023134-y665agnh 421 22 Maltese Maltese NNP cord-023134-y665agnh 421 23 ( ( -LRB- cord-023134-y665agnh 421 24 n n NN cord-023134-y665agnh 421 25 = = SYM cord-023134-y665agnh 421 26 7 7 CD cord-023134-y665agnh 421 27 ) ) -RRB- cord-023134-y665agnh 421 28 , , , cord-023134-y665agnh 421 29 Yorkshire Yorkshire NNP cord-023134-y665agnh 421 30 Terrier Terrier NNP cord-023134-y665agnh 421 31 ( ( -LRB- cord-023134-y665agnh 421 32 n n NN cord-023134-y665agnh 421 33 = = SYM cord-023134-y665agnh 421 34 3 3 CD cord-023134-y665agnh 421 35 ) ) -RRB- cord-023134-y665agnh 421 36 , , , cord-023134-y665agnh 421 37 Shih Shih NNP cord-023134-y665agnh 421 38 Tzu Tzu NNP cord-023134-y665agnh 421 39 ( ( -LRB- cord-023134-y665agnh 421 40 n n NN cord-023134-y665agnh 421 41 = = SYM cord-023134-y665agnh 421 42 2 2 CD cord-023134-y665agnh 421 43 ) ) -RRB- cord-023134-y665agnh 421 44 , , , cord-023134-y665agnh 421 45 Miniature Miniature NNP cord-023134-y665agnh 421 46 Dachshund Dachshund NNP cord-023134-y665agnh 421 47 ( ( -LRB- cord-023134-y665agnh 421 48 n n NN cord-023134-y665agnh 421 49 = = SYM cord-023134-y665agnh 421 50 2 2 CD cord-023134-y665agnh 421 51 ) ) -RRB- cord-023134-y665agnh 421 52 , , , cord-023134-y665agnh 421 53 and and CC cord-023134-y665agnh 421 54 others other NNS cord-023134-y665agnh 421 55 ( ( -LRB- cord-023134-y665agnh 421 56 n n NN cord-023134-y665agnh 421 57 = = SYM cord-023134-y665agnh 421 58 10 10 CD cord-023134-y665agnh 421 59 ) ) -RRB- cord-023134-y665agnh 421 60 . . . cord-023134-y665agnh 422 1 No no DT cord-023134-y665agnh 422 2 significant significant JJ cord-023134-y665agnh 422 3 difference difference NN cord-023134-y665agnh 422 4 was be VBD cord-023134-y665agnh 422 5 found find VBN cord-023134-y665agnh 422 6 for for IN cord-023134-y665agnh 422 7 age age NN cord-023134-y665agnh 422 8 and and CC cord-023134-y665agnh 422 9 body body NN cord-023134-y665agnh 422 10 weight weight NN cord-023134-y665agnh 422 11 . . . cord-023134-y665agnh 423 1 The the DT cord-023134-y665agnh 423 2 vertebral vertebral JJ cord-023134-y665agnh 423 3 heart heart NN cord-023134-y665agnh 423 4 size size NN cord-023134-y665agnh 423 5 and and CC cord-023134-y665agnh 423 6 LA LA NNP cord-023134-y665agnh 423 7 / / SYM cord-023134-y665agnh 423 8 Ao Ao NNP cord-023134-y665agnh 423 9 ratio ratio NN cord-023134-y665agnh 423 10 significantly significantly RB cord-023134-y665agnh 423 11 decreased decrease VBD cord-023134-y665agnh 423 12 after after IN cord-023134-y665agnh 423 13 surgery surgery NN cord-023134-y665agnh 423 14 compared compare VBN cord-023134-y665agnh 423 15 with with IN cord-023134-y665agnh 423 16 the the DT cord-023134-y665agnh 423 17 preoperative preoperative JJ cord-023134-y665agnh 423 18 values value NNS cord-023134-y665agnh 423 19 . . . cord-023134-y665agnh 424 1 Before before IN cord-023134-y665agnh 424 2 the the DT cord-023134-y665agnh 424 3 operation operation NN cord-023134-y665agnh 424 4 , , , cord-023134-y665agnh 424 5 CRP CRP NNP cord-023134-y665agnh 424 6 concentration concentration NN cord-023134-y665agnh 424 7 and and CC cord-023134-y665agnh 424 8 white white JJ cord-023134-y665agnh 424 9 blood blood NN cord-023134-y665agnh 424 10 cell cell NN cord-023134-y665agnh 424 11 counts count VBZ cord-023134-y665agnh 424 12 in in IN cord-023134-y665agnh 424 13 ISACHC isachc JJ cord-023134-y665agnh 424 14 class class NN cord-023134-y665agnh 424 15 IIIb iiib NN cord-023134-y665agnh 424 16 dogs dog NNS cord-023134-y665agnh 424 17 ( ( -LRB- cord-023134-y665agnh 424 18 2.5 2.5 CD cord-023134-y665agnh 424 19 ± ± CD cord-023134-y665agnh 424 20 2.3 2.3 CD cord-023134-y665agnh 424 21 mg mg NNP cord-023134-y665agnh 424 22 / / SYM cord-023134-y665agnh 424 23 dL dl NN cord-023134-y665agnh 424 24 and and CC cord-023134-y665agnh 424 25 21288 21288 CD cord-023134-y665agnh 425 1 ± ± NNP cord-023134-y665agnh 425 2 7656 7656 CD cord-023134-y665agnh 425 3 /lL /lL NFP cord-023134-y665agnh 425 4 , , , cord-023134-y665agnh 425 5 respectively respectively RB cord-023134-y665agnh 425 6 ) ) -RRB- cord-023134-y665agnh 425 7 were be VBD cord-023134-y665agnh 425 8 higher high JJR cord-023134-y665agnh 425 9 than than IN cord-023134-y665agnh 425 10 those those DT cord-023134-y665agnh 425 11 in in IN cord-023134-y665agnh 425 12 class class NN cord-023134-y665agnh 425 13 Ib Ib NNP cord-023134-y665agnh 425 14 ( ( -LRB- cord-023134-y665agnh 425 15 0.2 0.2 CD cord-023134-y665agnh 425 16 ± ± CD cord-023134-y665agnh 425 17 0.3 0.3 CD cord-023134-y665agnh 425 18 mg mg NNP cord-023134-y665agnh 425 19 / / SYM cord-023134-y665agnh 425 20 dL dl NN cord-023134-y665agnh 425 21 and and CC cord-023134-y665agnh 425 22 11500 11500 CD cord-023134-y665agnh 425 23 ± ± CD cord-023134-y665agnh 425 24 1320 1320 CD cord-023134-y665agnh 425 25 /lL /lL NFP cord-023134-y665agnh 425 26 , , , cord-023134-y665agnh 425 27 respectively respectively RB cord-023134-y665agnh 425 28 ) ) -RRB- cord-023134-y665agnh 425 29 , , , cord-023134-y665agnh 425 30 class class NN cord-023134-y665agnh 425 31 II ii NN cord-023134-y665agnh 425 32 ( ( -LRB- cord-023134-y665agnh 425 33 0.1 0.1 CD cord-023134-y665agnh 425 34 ± ± CD cord-023134-y665agnh 425 35 0.1 0.1 CD cord-023134-y665agnh 425 36 mg mg NNP cord-023134-y665agnh 425 37 / / SYM cord-023134-y665agnh 425 38 dL dl NN cord-023134-y665agnh 425 39 and and CC cord-023134-y665agnh 425 40 8822 8822 CD cord-023134-y665agnh 425 41 ± ± XX cord-023134-y665agnh 426 1 2243 2243 CD cord-023134-y665agnh 426 2 / / SYM cord-023134-y665agnh 426 3 lL lL NNP cord-023134-y665agnh 426 4 , , , cord-023134-y665agnh 426 5 respectively respectively RB cord-023134-y665agnh 426 6 ) ) -RRB- cord-023134-y665agnh 426 7 , , , cord-023134-y665agnh 426 8 and and CC cord-023134-y665agnh 426 9 class class NN cord-023134-y665agnh 426 10 IIIa iiia NN cord-023134-y665agnh 426 11 ( ( -LRB- cord-023134-y665agnh 426 12 0.7 0.7 CD cord-023134-y665agnh 426 13 ± ± CD cord-023134-y665agnh 426 14 1.8 1.8 CD cord-023134-y665agnh 426 15 mg mg NNP cord-023134-y665agnh 426 16 / / SYM cord-023134-y665agnh 426 17 dL dl NN cord-023134-y665agnh 426 18 and and CC cord-023134-y665agnh 426 19 11731 11731 CD cord-023134-y665agnh 426 20 ± ± CD cord-023134-y665agnh 427 1 4620 4620 CD cord-023134-y665agnh 428 1 /lL /lL NFP cord-023134-y665agnh 428 2 , , , cord-023134-y665agnh 428 3 respectively respectively RB cord-023134-y665agnh 428 4 ) ) -RRB- cord-023134-y665agnh 428 5 dogs dog NNS cord-023134-y665agnh 428 6 . . . cord-023134-y665agnh 429 1 Additionally additionally RB cord-023134-y665agnh 429 2 , , , cord-023134-y665agnh 429 3 CRP CRP NNP cord-023134-y665agnh 429 4 concentration concentration NN cord-023134-y665agnh 429 5 and and CC cord-023134-y665agnh 429 6 white white JJ cord-023134-y665agnh 429 7 blood blood NN cord-023134-y665agnh 429 8 cell cell NN cord-023134-y665agnh 429 9 counts count VBZ cord-023134-y665agnh 429 10 in in IN cord-023134-y665agnh 429 11 class class NN cord-023134-y665agnh 429 12 IIIb iiib NN cord-023134-y665agnh 429 13 dogs dog NNS cord-023134-y665agnh 429 14 significantly significantly RB cord-023134-y665agnh 429 15 decreased decrease VBD cord-023134-y665agnh 429 16 after after IN cord-023134-y665agnh 429 17 surgery surgery NN cord-023134-y665agnh 429 18 compared compare VBN cord-023134-y665agnh 429 19 with with IN cord-023134-y665agnh 429 20 preoperative preoperative JJ cord-023134-y665agnh 429 21 values value NNS cord-023134-y665agnh 429 22 . . . cord-023134-y665agnh 430 1 CRP CRP NNP cord-023134-y665agnh 430 2 concentration concentration NN cord-023134-y665agnh 430 3 and and CC cord-023134-y665agnh 430 4 white white JJ cord-023134-y665agnh 430 5 blood blood NN cord-023134-y665agnh 430 6 cell cell NN cord-023134-y665agnh 430 7 counts count VBZ cord-023134-y665agnh 430 8 in in IN cord-023134-y665agnh 430 9 the the DT cord-023134-y665agnh 430 10 dogs dog NNS cord-023134-y665agnh 430 11 with with IN cord-023134-y665agnh 430 12 cardiogenic cardiogenic JJ cord-023134-y665agnh 430 13 pulmonary pulmonary JJ cord-023134-y665agnh 430 14 edema edema NN cord-023134-y665agnh 430 15 significantly significantly RB cord-023134-y665agnh 430 16 increased increase VBD cord-023134-y665agnh 430 17 compared compare VBN cord-023134-y665agnh 430 18 with with IN cord-023134-y665agnh 430 19 those those DT cord-023134-y665agnh 430 20 with with IN cord-023134-y665agnh 430 21 non non JJ cord-023134-y665agnh 430 22 - - JJ cord-023134-y665agnh 430 23 pulmonary pulmonary JJ cord-023134-y665agnh 430 24 edema edema NN cord-023134-y665agnh 430 25 . . . cord-023134-y665agnh 431 1 Furthermore furthermore RB cord-023134-y665agnh 431 2 , , , cord-023134-y665agnh 431 3 cardiogenic cardiogenic JJ cord-023134-y665agnh 431 4 pulmonary pulmonary JJ cord-023134-y665agnh 431 5 edema edema NN cord-023134-y665agnh 431 6 disappeared disappear VBD cord-023134-y665agnh 431 7 within within IN cord-023134-y665agnh 431 8 3 3 CD cord-023134-y665agnh 431 9 months month NNS cord-023134-y665agnh 431 10 after after IN cord-023134-y665agnh 431 11 surgery surgery NN cord-023134-y665agnh 431 12 , , , cord-023134-y665agnh 431 13 and and CC cord-023134-y665agnh 431 14 the the DT cord-023134-y665agnh 431 15 CRP CRP NNP cord-023134-y665agnh 431 16 concentrations concentration NNS cord-023134-y665agnh 431 17 and and CC cord-023134-y665agnh 431 18 white white JJ cord-023134-y665agnh 431 19 blood blood NN cord-023134-y665agnh 431 20 cell cell NN cord-023134-y665agnh 431 21 counts count NNS cord-023134-y665agnh 431 22 became become VBD cord-023134-y665agnh 431 23 normal normal JJ cord-023134-y665agnh 431 24 . . . cord-023134-y665agnh 432 1 In in IN cord-023134-y665agnh 432 2 conclusion conclusion NN cord-023134-y665agnh 432 3 , , , cord-023134-y665agnh 432 4 CRP CRP NNP cord-023134-y665agnh 432 5 concentration concentration NN cord-023134-y665agnh 432 6 increases increase VBZ cord-023134-y665agnh 432 7 in in IN cord-023134-y665agnh 432 8 dogs dog NNS cord-023134-y665agnh 432 9 with with IN cord-023134-y665agnh 432 10 MR MR NNP cord-023134-y665agnh 432 11 and and CC cord-023134-y665agnh 432 12 cardiogenic cardiogenic JJ cord-023134-y665agnh 432 13 pulmonary pulmonary JJ cord-023134-y665agnh 432 14 edema edema NN cord-023134-y665agnh 432 15 . . . cord-023134-y665agnh 433 1 It -PRON- PRP cord-023134-y665agnh 433 2 is be VBZ cord-023134-y665agnh 433 3 widely widely RB cord-023134-y665agnh 433 4 recognized recognize VBN cord-023134-y665agnh 433 5 that that IN cord-023134-y665agnh 433 6 inflammatory inflammatory JJ cord-023134-y665agnh 433 7 reaction reaction NN cord-023134-y665agnh 433 8 plays play VBZ cord-023134-y665agnh 433 9 a a DT cord-023134-y665agnh 433 10 key key JJ cord-023134-y665agnh 433 11 role role NN cord-023134-y665agnh 433 12 in in IN cord-023134-y665agnh 433 13 the the DT cord-023134-y665agnh 433 14 development development NN cord-023134-y665agnh 433 15 of of IN cord-023134-y665agnh 433 16 heart heart NN cord-023134-y665agnh 433 17 failure failure NN cord-023134-y665agnh 433 18 . . . cord-023134-y665agnh 434 1 Consequently consequently RB cord-023134-y665agnh 434 2 , , , cord-023134-y665agnh 434 3 these these DT cord-023134-y665agnh 434 4 data datum NNS cord-023134-y665agnh 434 5 indicate indicate VBP cord-023134-y665agnh 434 6 the the DT cord-023134-y665agnh 434 7 importance importance NN cord-023134-y665agnh 434 8 of of IN cord-023134-y665agnh 434 9 strict strict JJ cord-023134-y665agnh 434 10 management management NN cord-023134-y665agnh 434 11 for for IN cord-023134-y665agnh 434 12 pulmonary pulmonary JJ cord-023134-y665agnh 434 13 edema edema NN cord-023134-y665agnh 434 14 and and CC cord-023134-y665agnh 434 15 inflammation inflammation NN cord-023134-y665agnh 434 16 . . . cord-023134-y665agnh 435 1 The the DT cord-023134-y665agnh 435 2 neurotransmitter neurotransmitter NN cord-023134-y665agnh 435 3 serotonin serotonin NN cord-023134-y665agnh 435 4 ( ( -LRB- cord-023134-y665agnh 435 5 5-hydroxytryptamine 5-hydroxytryptamine CD cord-023134-y665agnh 435 6 , , , cord-023134-y665agnh 435 7 5HT 5ht NN cord-023134-y665agnh 435 8 ) ) -RRB- cord-023134-y665agnh 435 9 has have VBZ cord-023134-y665agnh 435 10 recently recently RB cord-023134-y665agnh 435 11 been be VBN cord-023134-y665agnh 435 12 suggested suggest VBN cord-023134-y665agnh 435 13 to to TO cord-023134-y665agnh 435 14 have have VB cord-023134-y665agnh 435 15 a a DT cord-023134-y665agnh 435 16 role role NN cord-023134-y665agnh 435 17 in in IN cord-023134-y665agnh 435 18 development development NN cord-023134-y665agnh 435 19 of of IN cord-023134-y665agnh 435 20 myxomatous myxomatous JJ cord-023134-y665agnh 435 21 mitral mitral JJ cord-023134-y665agnh 435 22 valve valve NN cord-023134-y665agnh 435 23 disease disease NN cord-023134-y665agnh 435 24 ( ( -LRB- cord-023134-y665agnh 435 25 MMVD MMVD NNP cord-023134-y665agnh 435 26 ) ) -RRB- cord-023134-y665agnh 435 27 in in IN cord-023134-y665agnh 435 28 dogs dog NNS cord-023134-y665agnh 435 29 . . . cord-023134-y665agnh 436 1 The the DT cord-023134-y665agnh 436 2 aim aim NN cord-023134-y665agnh 436 3 of of IN cord-023134-y665agnh 436 4 this this DT cord-023134-y665agnh 436 5 study study NN cord-023134-y665agnh 436 6 was be VBD cord-023134-y665agnh 436 7 to to TO cord-023134-y665agnh 436 8 investigate investigate VB cord-023134-y665agnh 436 9 whether whether IN cord-023134-y665agnh 436 10 serum serum NN cord-023134-y665agnh 436 11 5HT 5ht NN cord-023134-y665agnh 436 12 concentration concentration NN cord-023134-y665agnh 436 13 was be VBD cord-023134-y665agnh 436 14 associated associate VBN cord-023134-y665agnh 436 15 with with IN cord-023134-y665agnh 436 16 MMVD MMVD NNP cord-023134-y665agnh 436 17 severity severity NN cord-023134-y665agnh 436 18 in in IN cord-023134-y665agnh 436 19 dogs dog NNS cord-023134-y665agnh 436 20 , , , cord-023134-y665agnh 436 21 and and CC cord-023134-y665agnh 436 22 to to TO cord-023134-y665agnh 436 23 assess assess VB cord-023134-y665agnh 436 24 potential potential JJ cord-023134-y665agnh 436 25 associations association NNS cord-023134-y665agnh 436 26 between between IN cord-023134-y665agnh 436 27 serum serum NN cord-023134-y665agnh 436 28 5HT 5ht NN cord-023134-y665agnh 436 29 concentrations concentration NNS cord-023134-y665agnh 436 30 and and CC cord-023134-y665agnh 436 31 dog dog NN cord-023134-y665agnh 436 32 characteristics characteristic NNS cord-023134-y665agnh 436 33 , , , cord-023134-y665agnh 436 34 echocardiographic echocardiographic JJ cord-023134-y665agnh 436 35 variables variable NNS cord-023134-y665agnh 436 36 , , , cord-023134-y665agnh 436 37 heart heart NN cord-023134-y665agnh 436 38 rate rate NN cord-023134-y665agnh 436 39 , , , cord-023134-y665agnh 436 40 systolic systolic JJ cord-023134-y665agnh 436 41 blood blood NN cord-023134-y665agnh 436 42 pressure pressure NN cord-023134-y665agnh 436 43 , , , cord-023134-y665agnh 436 44 and and CC cord-023134-y665agnh 436 45 platelet platelet NN cord-023134-y665agnh 436 46 size size NN cord-023134-y665agnh 436 47 ( ( -LRB- cord-023134-y665agnh 436 48 mean mean VB cord-023134-y665agnh 436 49 platelet platelet NN cord-023134-y665agnh 436 50 volume volume NN cord-023134-y665agnh 436 51 ) ) -RRB- cord-023134-y665agnh 436 52 in in IN cord-023134-y665agnh 436 53 the the DT cord-023134-y665agnh 436 54 study study NN cord-023134-y665agnh 436 55 population.120 population.120 NN cord-023134-y665agnh 436 56 client client NN cord-023134-y665agnh 436 57 - - HYPH cord-023134-y665agnh 436 58 owned own VBN cord-023134-y665agnh 436 59 dogs dog NNS cord-023134-y665agnh 436 60 with with IN cord-023134-y665agnh 436 61 naturally naturally RB cord-023134-y665agnh 436 62 acquired acquire VBN cord-023134-y665agnh 436 63 MMVD MMVD NNP cord-023134-y665agnh 436 64 of of IN cord-023134-y665agnh 436 65 varying vary VBG cord-023134-y665agnh 436 66 severity severity NN cord-023134-y665agnh 436 67 were be VBD cord-023134-y665agnh 436 68 prospectively prospectively RB cord-023134-y665agnh 436 69 recruited recruit VBN cord-023134-y665agnh 436 70 for for IN cord-023134-y665agnh 436 71 the the DT cord-023134-y665agnh 436 72 study study NN cord-023134-y665agnh 436 73 . . . cord-023134-y665agnh 437 1 Dogs dog NNS cord-023134-y665agnh 437 2 were be VBD cord-023134-y665agnh 437 3 classified classify VBN cord-023134-y665agnh 437 4 according accord VBG cord-023134-y665agnh 437 5 to to IN cord-023134-y665agnh 437 6 MMVD MMVD NNP cord-023134-y665agnh 437 7 severity severity NN cord-023134-y665agnh 437 8 ( ( -LRB- cord-023134-y665agnh 437 9 breeds breed NNS cord-023134-y665agnh 437 10 predisposed predisposed JJ cord-023134-y665agnh 437 11 to to IN cord-023134-y665agnh 437 12 early early JJ cord-023134-y665agnh 437 13 onset onset NN cord-023134-y665agnh 437 14 of of IN cord-023134-y665agnh 437 15 MMVD MMVD NNP cord-023134-y665agnh 437 16 , , , cord-023134-y665agnh 437 17 but but CC cord-023134-y665agnh 437 18 without without IN cord-023134-y665agnh 437 19 echocardiographic echocardiographic JJ cord-023134-y665agnh 437 20 evidence evidence NN cord-023134-y665agnh 437 21 of of IN cord-023134-y665agnh 437 22 the the DT cord-023134-y665agnh 437 23 disease disease NN cord-023134-y665agnh 437 24 , , , cord-023134-y665agnh 437 25 or or CC cord-023134-y665agnh 437 26 mild mild JJ cord-023134-y665agnh 437 27 , , , cord-023134-y665agnh 437 28 moderate moderate JJ cord-023134-y665agnh 437 29 or or CC cord-023134-y665agnh 437 30 severe severe JJ cord-023134-y665agnh 437 31 disease disease NN cord-023134-y665agnh 437 32 ) ) -RRB- cord-023134-y665agnh 437 33 . . . cord-023134-y665agnh 438 1 Serum serum NN cord-023134-y665agnh 438 2 5HT 5ht NN cord-023134-y665agnh 438 3 concentrations concentration NNS cord-023134-y665agnh 438 4 were be VBD cord-023134-y665agnh 438 5 analyzed analyze VBN cord-023134-y665agnh 438 6 using use VBG cord-023134-y665agnh 438 7 an an DT cord-023134-y665agnh 438 8 ELISA ELISA NNP cord-023134-y665agnh 438 9 assay assay NN cord-023134-y665agnh 438 10 . . . cord-023134-y665agnh 439 1 Lower low JJR cord-023134-y665agnh 439 2 serum serum NN cord-023134-y665agnh 439 3 5HT 5ht NN cord-023134-y665agnh 439 4 concentrations concentration NNS cord-023134-y665agnh 439 5 were be VBD cord-023134-y665agnh 439 6 shown show VBN cord-023134-y665agnh 439 7 in in IN cord-023134-y665agnh 439 8 dogs dog NNS cord-023134-y665agnh 439 9 with with IN cord-023134-y665agnh 439 10 severe severe JJ cord-023134-y665agnh 439 11 MMVD MMVD NNP cord-023134-y665agnh 439 12 , , , cord-023134-y665agnh 439 13 compared compare VBN cord-023134-y665agnh 439 14 with with IN cord-023134-y665agnh 439 15 dogs dog NNS cord-023134-y665agnh 439 16 predisposed predisposed JJ cord-023134-y665agnh 439 17 to to IN cord-023134-y665agnh 439 18 MMVD MMVD NNP cord-023134-y665agnh 439 19 ( ( -LRB- cord-023134-y665agnh 439 20 P p NN cord-023134-y665agnh 439 21 = = SYM cord-023134-y665agnh 439 22 0.0025 0.0025 CD cord-023134-y665agnh 439 23 ) ) -RRB- cord-023134-y665agnh 439 24 and and CC cord-023134-y665agnh 439 25 dogs dog NNS cord-023134-y665agnh 439 26 with with IN cord-023134-y665agnh 439 27 mild mild JJ cord-023134-y665agnh 439 28 MMVD MMVD NNP cord-023134-y665agnh 439 29 ( ( -LRB- cord-023134-y665agnh 439 30 P p NN cord-023134-y665agnh 439 31 = = SYM cord-023134-y665agnh 439 32 0.0011 0.0011 CD cord-023134-y665agnh 439 33 ) ) -RRB- cord-023134-y665agnh 439 34 . . . cord-023134-y665agnh 440 1 Unilinear unilinear JJ cord-023134-y665agnh 440 2 and and CC cord-023134-y665agnh 440 3 multiple multiple JJ cord-023134-y665agnh 440 4 regression regression NN cord-023134-y665agnh 440 5 analyses analysis NNS cord-023134-y665agnh 440 6 showed show VBD cord-023134-y665agnh 440 7 that that IN cord-023134-y665agnh 440 8 serum serum NN cord-023134-y665agnh 440 9 5HT 5ht NN cord-023134-y665agnh 440 10 concentrations concentration NNS cord-023134-y665agnh 440 11 decreased decrease VBD cord-023134-y665agnh 440 12 with with IN cord-023134-y665agnh 440 13 increasing increase VBG cord-023134-y665agnh 440 14 left left JJ cord-023134-y665agnh 440 15 atrial atrial NN cord-023134-y665agnh 440 16 to to IN cord-023134-y665agnh 440 17 aortic aortic JJ cord-023134-y665agnh 440 18 root root NN cord-023134-y665agnh 440 19 ratio ratio NN cord-023134-y665agnh 440 20 ( ( -LRB- cord-023134-y665agnh 440 21 LA LA NNP cord-023134-y665agnh 440 22 / / SYM cord-023134-y665agnh 440 23 Ao Ao NNP cord-023134-y665agnh 440 24 ) ) -RRB- cord-023134-y665agnh 440 25 , , , cord-023134-y665agnh 440 26 were be VBD cord-023134-y665agnh 440 27 higher high JJR cord-023134-y665agnh 440 28 in in IN cord-023134-y665agnh 440 29 Cavalier Cavalier NNP cord-023134-y665agnh 440 30 King King NNP cord-023134-y665agnh 440 31 Charles Charles NNP cord-023134-y665agnh 440 32 Spaniel Spaniel NNP cord-023134-y665agnh 440 33 ( ( -LRB- cord-023134-y665agnh 440 34 CKCS CKCS NNP cord-023134-y665agnh 440 35 ) ) -RRB- cord-023134-y665agnh 440 36 dogs dog NNS cord-023134-y665agnh 440 37 compared compare VBN cord-023134-y665agnh 440 38 to to IN cord-023134-y665agnh 440 39 dogs dog NNS cord-023134-y665agnh 440 40 of of IN cord-023134-y665agnh 440 41 other other JJ cord-023134-y665agnh 440 42 breeds breed NNS cord-023134-y665agnh 440 43 , , , cord-023134-y665agnh 440 44 and and CC cord-023134-y665agnh 440 45 were be VBD cord-023134-y665agnh 440 46 higher high JJR cord-023134-y665agnh 440 47 in in IN cord-023134-y665agnh 440 48 female female JJ cord-023134-y665agnh 440 49 dogs dog NNS cord-023134-y665agnh 440 50 than than IN cord-023134-y665agnh 440 51 in in IN cord-023134-y665agnh 440 52 male male JJ cord-023134-y665agnh 440 53 dogs dog NNS cord-023134-y665agnh 440 54 . . . cord-023134-y665agnh 441 1 The the DT cord-023134-y665agnh 441 2 LA LA NNP cord-023134-y665agnh 441 3 / / SYM cord-023134-y665agnh 441 4 Ao Ao NNP cord-023134-y665agnh 441 5 was be VBD cord-023134-y665agnh 441 6 the the DT cord-023134-y665agnh 441 7 variable variable NN cord-023134-y665agnh 441 8 most most RBS cord-023134-y665agnh 441 9 strongly strongly RB cord-023134-y665agnh 441 10 associated associate VBN cord-023134-y665agnh 441 11 with with IN cord-023134-y665agnh 441 12 serum serum NN cord-023134-y665agnh 441 13 5HT 5ht NN cord-023134-y665agnh 441 14 concentration concentration NN cord-023134-y665agnh 441 15 . . . cord-023134-y665agnh 442 1 In in IN cord-023134-y665agnh 442 2 conclusion conclusion NN cord-023134-y665agnh 442 3 , , , cord-023134-y665agnh 442 4 the the DT cord-023134-y665agnh 442 5 finding finding NN cord-023134-y665agnh 442 6 of of IN cord-023134-y665agnh 442 7 higher high JJR cord-023134-y665agnh 442 8 serum serum NN cord-023134-y665agnh 442 9 5HT 5ht NN cord-023134-y665agnh 442 10 concentrations concentration NNS cord-023134-y665agnh 442 11 in in IN cord-023134-y665agnh 442 12 dogs dog NNS cord-023134-y665agnh 442 13 predisposed predisposed JJ cord-023134-y665agnh 442 14 to to IN cord-023134-y665agnh 442 15 MMVD MMVD NNP cord-023134-y665agnh 442 16 ( ( -LRB- cord-023134-y665agnh 442 17 CKCS CKCS NNP cord-023134-y665agnh 442 18 ) ) -RRB- cord-023134-y665agnh 442 19 and and CC cord-023134-y665agnh 442 20 dogs dog NNS cord-023134-y665agnh 442 21 with with IN cord-023134-y665agnh 442 22 mild mild JJ cord-023134-y665agnh 442 23 MMVD MMVD NNP cord-023134-y665agnh 442 24 suggests suggest VBZ cord-023134-y665agnh 442 25 that that IN cord-023134-y665agnh 442 26 alterations alteration NNS cord-023134-y665agnh 442 27 in in IN cord-023134-y665agnh 442 28 5HT 5ht NN cord-023134-y665agnh 442 29 signaling signaling NN cord-023134-y665agnh 442 30 might may MD cord-023134-y665agnh 442 31 play play VB cord-023134-y665agnh 442 32 a a DT cord-023134-y665agnh 442 33 role role NN cord-023134-y665agnh 442 34 in in IN cord-023134-y665agnh 442 35 progression progression NN cord-023134-y665agnh 442 36 of of IN cord-023134-y665agnh 442 37 early early JJ cord-023134-y665agnh 442 38 stages stage NNS cord-023134-y665agnh 442 39 of of IN cord-023134-y665agnh 442 40 MMVD MMVD NNP cord-023134-y665agnh 442 41 . . . cord-023134-y665agnh 443 1 Hypersomatotropism Hypersomatotropism NNP cord-023134-y665agnh 443 2 ( ( -LRB- cord-023134-y665agnh 443 3 HS HS NNP cord-023134-y665agnh 443 4 ) ) -RRB- cord-023134-y665agnh 443 5 can can MD cord-023134-y665agnh 443 6 be be VB cord-023134-y665agnh 443 7 a a DT cord-023134-y665agnh 443 8 common common JJ cord-023134-y665agnh 443 9 reason reason NN cord-023134-y665agnh 443 10 for for IN cord-023134-y665agnh 443 11 development development NN cord-023134-y665agnh 443 12 of of IN cord-023134-y665agnh 443 13 diabetes diabetes NN cord-023134-y665agnh 443 14 mellitus mellitus NN cord-023134-y665agnh 443 15 in in IN cord-023134-y665agnh 443 16 the the DT cord-023134-y665agnh 443 17 cat cat NN cord-023134-y665agnh 443 18 . . . cord-023134-y665agnh 444 1 Remission remission NN cord-023134-y665agnh 444 2 of of IN cord-023134-y665agnh 444 3 diabetes diabetes NN cord-023134-y665agnh 444 4 can can MD cord-023134-y665agnh 444 5 be be VB cord-023134-y665agnh 444 6 achieved achieve VBN cord-023134-y665agnh 444 7 with with IN cord-023134-y665agnh 444 8 an an DT cord-023134-y665agnh 444 9 accurate accurate JJ cord-023134-y665agnh 444 10 diagnosis diagnosis NN cord-023134-y665agnh 444 11 of of IN cord-023134-y665agnh 444 12 the the DT cord-023134-y665agnh 444 13 HS HS NNP cord-023134-y665agnh 444 14 , , , cord-023134-y665agnh 444 15 although although IN cord-023134-y665agnh 444 16 diagnosis diagnosis NN cord-023134-y665agnh 444 17 is be VBZ cord-023134-y665agnh 444 18 hampered hamper VBN cord-023134-y665agnh 444 19 by by IN cord-023134-y665agnh 444 20 the the DT cord-023134-y665agnh 444 21 relative relative JJ cord-023134-y665agnh 444 22 complexity complexity NN cord-023134-y665agnh 444 23 of of IN cord-023134-y665agnh 444 24 confirming confirm VBG cord-023134-y665agnh 444 25 HS HS NNP cord-023134-y665agnh 444 26 , , , cord-023134-y665agnh 444 27 requiring require VBG cord-023134-y665agnh 444 28 a a DT cord-023134-y665agnh 444 29 combination combination NN cord-023134-y665agnh 444 30 of of IN cord-023134-y665agnh 444 31 insulin insulin NN cord-023134-y665agnh 444 32 growth growth NN cord-023134-y665agnh 444 33 factor-1 factor-1 NNP cord-023134-y665agnh 444 34 ( ( -LRB- cord-023134-y665agnh 444 35 IGF-1 IGF-1 NNP cord-023134-y665agnh 444 36 ) ) -RRB- cord-023134-y665agnh 444 37 or or CC cord-023134-y665agnh 444 38 feline feline JJ cord-023134-y665agnh 444 39 growth growth NN cord-023134-y665agnh 444 40 hormone hormone NN cord-023134-y665agnh 444 41 measurement measurement NN cord-023134-y665agnh 444 42 and and CC cord-023134-y665agnh 444 43 intracranial intracranial JJ cord-023134-y665agnh 444 44 imaging imaging NN cord-023134-y665agnh 444 45 . . . cord-023134-y665agnh 445 1 Unfortunately unfortunately RB cord-023134-y665agnh 445 2 , , , cord-023134-y665agnh 445 3 all all DT cord-023134-y665agnh 445 4 three three CD cord-023134-y665agnh 445 5 have have VBP cord-023134-y665agnh 445 6 limitations limitation NNS cord-023134-y665agnh 445 7 as as IN cord-023134-y665agnh 445 8 diagnostic diagnostic JJ cord-023134-y665agnh 445 9 aid aid NN cord-023134-y665agnh 445 10 and and CC cord-023134-y665agnh 445 11 when when WRB cord-023134-y665agnh 445 12 evaluating evaluate VBG cord-023134-y665agnh 445 13 the the DT cord-023134-y665agnh 445 14 success success NN cord-023134-y665agnh 445 15 of of IN cord-023134-y665agnh 445 16 therapy therapy NN cord-023134-y665agnh 445 17 , , , cord-023134-y665agnh 445 18 particularly particularly RB cord-023134-y665agnh 445 19 radiotherapy radiotherapy NNP cord-023134-y665agnh 445 20 ( ( -LRB- cord-023134-y665agnh 445 21 RT RT NNP cord-023134-y665agnh 445 22 ) ) -RRB- cord-023134-y665agnh 445 23 . . . cord-023134-y665agnh 446 1 Consequently consequently RB cord-023134-y665agnh 446 2 , , , cord-023134-y665agnh 446 3 more more RBR cord-023134-y665agnh 446 4 precise precise JJ cord-023134-y665agnh 446 5 markers marker NNS cord-023134-y665agnh 446 6 of of IN cord-023134-y665agnh 446 7 HS HS NNP cord-023134-y665agnh 446 8 are be VBP cord-023134-y665agnh 446 9 required require VBN cord-023134-y665agnh 446 10 . . . cord-023134-y665agnh 447 1 The the DT cord-023134-y665agnh 447 2 current current JJ cord-023134-y665agnh 447 3 study study NN cord-023134-y665agnh 447 4 aimed aim VBN cord-023134-y665agnh 447 5 to to TO cord-023134-y665agnh 447 6 evaluate evaluate VB cord-023134-y665agnh 447 7 physiological physiological JJ cord-023134-y665agnh 447 8 behaviour behaviour NN cord-023134-y665agnh 447 9 and and CC cord-023134-y665agnh 447 10 diagnostic diagnostic JJ cord-023134-y665agnh 447 11 potential potential NN cord-023134-y665agnh 447 12 of of IN cord-023134-y665agnh 447 13 serum serum NN cord-023134-y665agnh 447 14 ghrelin ghrelin NN cord-023134-y665agnh 447 15 in in IN cord-023134-y665agnh 447 16 feline feline JJ cord-023134-y665agnh 447 17 HS hs NN cord-023134-y665agnh 447 18 . . . cord-023134-y665agnh 448 1 As as IN cord-023134-y665agnh 448 2 ghrelin ghrelin NN cord-023134-y665agnh 448 3 is be VBZ cord-023134-y665agnh 448 4 an an DT cord-023134-y665agnh 448 5 endogenous endogenous JJ cord-023134-y665agnh 448 6 ligand ligand NN cord-023134-y665agnh 448 7 of of IN cord-023134-y665agnh 448 8 the the DT cord-023134-y665agnh 448 9 GH GH NNP cord-023134-y665agnh 448 10 secretagogue secretagogue NN cord-023134-y665agnh 448 11 receptor receptor NN cord-023134-y665agnh 448 12 , , , cord-023134-y665agnh 448 13 it -PRON- PRP cord-023134-y665agnh 448 14 was be VBD cord-023134-y665agnh 448 15 hypothesised hypothesise VBN cord-023134-y665agnh 448 16 production production NN cord-023134-y665agnh 448 17 of of IN cord-023134-y665agnh 448 18 ghrelin ghrelin NN cord-023134-y665agnh 448 19 might may MD cord-023134-y665agnh 448 20 be be VB cord-023134-y665agnh 448 21 suppressed suppress VBN cord-023134-y665agnh 448 22 in in IN cord-023134-y665agnh 448 23 HS HS NNP cord-023134-y665agnh 448 24 and and CC cord-023134-y665agnh 448 25 subnormal subnormal JJ cord-023134-y665agnh 448 26 serum serum NN cord-023134-y665agnh 448 27 levels level NNS cord-023134-y665agnh 448 28 could could MD cord-023134-y665agnh 448 29 be be VB cord-023134-y665agnh 448 30 a a DT cord-023134-y665agnh 448 31 marker marker NN cord-023134-y665agnh 448 32 for for IN cord-023134-y665agnh 448 33 increased increase VBN cord-023134-y665agnh 448 34 GH GH NNP cord-023134-y665agnh 448 35 activity activity NN cord-023134-y665agnh 448 36 . . . cord-023134-y665agnh 449 1 Fasted fast VBN cord-023134-y665agnh 449 2 ( ( -LRB- cord-023134-y665agnh 449 3 pre pre JJ cord-023134-y665agnh 449 4 - - JJ cord-023134-y665agnh 449 5 insulin insulin JJ cord-023134-y665agnh 449 6 ) ) -RRB- cord-023134-y665agnh 449 7 serum serum NN cord-023134-y665agnh 449 8 samples sample NNS cord-023134-y665agnh 449 9 were be VBD cord-023134-y665agnh 449 10 collected collect VBN cord-023134-y665agnh 449 11 from from IN cord-023134-y665agnh 449 12 20 20 CD cord-023134-y665agnh 449 13 normal normal JJ cord-023134-y665agnh 449 14 ( ( -LRB- cord-023134-y665agnh 449 15 age age NN cord-023134-y665agnh 449 16 matched match VBN cord-023134-y665agnh 449 17 control control NN cord-023134-y665agnh 449 18 ) ) -RRB- cord-023134-y665agnh 449 19 , , , cord-023134-y665agnh 449 20 20 20 CD cord-023134-y665agnh 449 21 uncomplicated uncomplicated JJ cord-023134-y665agnh 449 22 diabetic diabetic JJ cord-023134-y665agnh 449 23 ( ( -LRB- cord-023134-y665agnh 449 24 DM DM NNP cord-023134-y665agnh 449 25 ) ) -RRB- cord-023134-y665agnh 449 26 and and CC cord-023134-y665agnh 449 27 33 33 CD cord-023134-y665agnh 449 28 hypersomatotrophic hypersomatotrophic NN cord-023134-y665agnh 449 29 diabetic diabetic JJ cord-023134-y665agnh 449 30 ( ( -LRB- cord-023134-y665agnh 449 31 HSDM HSDM NNP cord-023134-y665agnh 449 32 ) ) -RRB- cord-023134-y665agnh 449 33 cats cat NNS cord-023134-y665agnh 449 34 . . . cord-023134-y665agnh 450 1 Cats cat NNS cord-023134-y665agnh 450 2 were be VBD cord-023134-y665agnh 450 3 categorized categorize VBN cord-023134-y665agnh 450 4 into into IN cord-023134-y665agnh 450 5 the the DT cord-023134-y665agnh 450 6 HSDM HSDM NNP cord-023134-y665agnh 450 7 - - HYPH cord-023134-y665agnh 450 8 group group NN cord-023134-y665agnh 450 9 on on IN cord-023134-y665agnh 450 10 the the DT cord-023134-y665agnh 450 11 basis basis NN cord-023134-y665agnh 450 12 of of IN cord-023134-y665agnh 450 13 elevated elevated JJ cord-023134-y665agnh 450 14 IGF-1 IGF-1 NNP cord-023134-y665agnh 450 15 ( ( -LRB- cord-023134-y665agnh 450 16 > > XX cord-023134-y665agnh 450 17 1000ng 1000ng NNP cord-023134-y665agnh 450 18 / / SYM cord-023134-y665agnh 450 19 ml ml NN cord-023134-y665agnh 450 20 ) ) -RRB- cord-023134-y665agnh 450 21 and and CC cord-023134-y665agnh 450 22 demonstration demonstration NN cord-023134-y665agnh 450 23 of of IN cord-023134-y665agnh 450 24 a a DT cord-023134-y665agnh 450 25 pituitary pituitary JJ cord-023134-y665agnh 450 26 lesion lesion NN cord-023134-y665agnh 450 27 on on IN cord-023134-y665agnh 450 28 imaging imaging NN cord-023134-y665agnh 450 29 . . . cord-023134-y665agnh 451 1 In in IN cord-023134-y665agnh 451 2 13 13 CD cord-023134-y665agnh 451 3 cats cat NNS cord-023134-y665agnh 451 4 additional additional JJ cord-023134-y665agnh 451 5 serum serum NN cord-023134-y665agnh 451 6 samples sample NNS cord-023134-y665agnh 451 7 were be VBD cord-023134-y665agnh 451 8 obtained obtain VBN cord-023134-y665agnh 451 9 following follow VBG cord-023134-y665agnh 451 10 RT RT NNP cord-023134-y665agnh 451 11 . . . cord-023134-y665agnh 452 1 Cats cat NNS cord-023134-y665agnh 452 2 were be VBD cord-023134-y665agnh 452 3 categorized categorize VBN cord-023134-y665agnh 452 4 into into IN cord-023134-y665agnh 452 5 the the DT cord-023134-y665agnh 452 6 DM dm NN cord-023134-y665agnh 452 7 - - HYPH cord-023134-y665agnh 452 8 group group NN cord-023134-y665agnh 452 9 on on IN cord-023134-y665agnh 452 10 the the DT cord-023134-y665agnh 452 11 basis basis NN cord-023134-y665agnh 452 12 of of IN cord-023134-y665agnh 452 13 low low JJ cord-023134-y665agnh 452 14 IGF-1 IGF-1 NNP cord-023134-y665agnh 452 15 ( ( -LRB- cord-023134-y665agnh 452 16 < < NNP cord-023134-y665agnh 452 17 700ng 700ng NNP cord-023134-y665agnh 452 18 / / SYM cord-023134-y665agnh 452 19 ml ml NN cord-023134-y665agnh 452 20 ) ) -RRB- cord-023134-y665agnh 452 21 and and CC cord-023134-y665agnh 452 22 normal normal JJ cord-023134-y665agnh 452 23 insulin insulin NN cord-023134-y665agnh 452 24 requirements requirement NNS cord-023134-y665agnh 452 25 ( ( -LRB- cord-023134-y665agnh 452 26 < < NNP cord-023134-y665agnh 452 27 1.5 1.5 CD cord-023134-y665agnh 452 28 iu iu NNP cord-023134-y665agnh 452 29 / / SYM cord-023134-y665agnh 452 30 kg kg NNP cord-023134-y665agnh 452 31 ) ) -RRB- cord-023134-y665agnh 452 32 . . . cord-023134-y665agnh 453 1 Serum serum NN cord-023134-y665agnh 453 2 ghrelin ghrelin NN cord-023134-y665agnh 453 3 was be VBD cord-023134-y665agnh 453 4 determined determine VBN cord-023134-y665agnh 453 5 using use VBG cord-023134-y665agnh 453 6 a a DT cord-023134-y665agnh 453 7 total total JJ cord-023134-y665agnh 453 8 ghrelin ghrelin NN cord-023134-y665agnh 453 9 ELISA ELISA NNP cord-023134-y665agnh 453 10 system system NN cord-023134-y665agnh 453 11 validated validate VBD cord-023134-y665agnh 453 12 for for IN cord-023134-y665agnh 453 13 the the DT cord-023134-y665agnh 453 14 cat cat NN cord-023134-y665agnh 453 15 . . . cord-023134-y665agnh 454 1 Data datum NNS cord-023134-y665agnh 454 2 were be VBD cord-023134-y665agnh 454 3 tested test VBN cord-023134-y665agnh 454 4 for for IN cord-023134-y665agnh 454 5 normality normality NN cord-023134-y665agnh 454 6 and and CC cord-023134-y665agnh 454 7 concentrations concentration NNS cord-023134-y665agnh 454 8 compared compare VBN cord-023134-y665agnh 454 9 between between IN cord-023134-y665agnh 454 10 groups group NNS cord-023134-y665agnh 454 11 using use VBG cord-023134-y665agnh 454 12 unpaired unpaired JJ cord-023134-y665agnh 454 13 t t NN cord-023134-y665agnh 454 14 - - HYPH cord-023134-y665agnh 454 15 tests test NNS cord-023134-y665agnh 454 16 and and CC cord-023134-y665agnh 454 17 a a DT cord-023134-y665agnh 454 18 paired paired JJ cord-023134-y665agnh 454 19 t t NN cord-023134-y665agnh 454 20 - - HYPH cord-023134-y665agnh 454 21 test test NN cord-023134-y665agnh 454 22 for for IN cord-023134-y665agnh 454 23 the the DT cord-023134-y665agnh 454 24 before before RB cord-023134-y665agnh 454 25 and and CC cord-023134-y665agnh 454 26 after after IN cord-023134-y665agnh 454 27 RT RT NNP cord-023134-y665agnh 454 28 HSDMgroups hsdmgroup NNS cord-023134-y665agnh 454 29 . . . cord-023134-y665agnh 455 1 Serum serum NN cord-023134-y665agnh 455 2 total total JJ cord-023134-y665agnh 455 3 ghrelin ghrelin NN cord-023134-y665agnh 455 4 was be VBD cord-023134-y665agnh 455 5 not not RB cord-023134-y665agnh 455 6 different different JJ cord-023134-y665agnh 455 7 between between IN cord-023134-y665agnh 455 8 the the DT cord-023134-y665agnh 455 9 HSDM HSDM NNP cord-023134-y665agnh 455 10 ( ( -LRB- cord-023134-y665agnh 455 11 7.9ng 7.9ng NNP cord-023134-y665agnh 455 12 / / SYM cord-023134-y665agnh 455 13 ml+/-3.3 ml+/-3.3 NNP cord-023134-y665agnh 455 14 ) ) -RRB- cord-023134-y665agnh 455 15 and and CC cord-023134-y665agnh 455 16 DM dm NN cord-023134-y665agnh 455 17 - - HYPH cord-023134-y665agnh 455 18 group group NN cord-023134-y665agnh 455 19 ( ( -LRB- cord-023134-y665agnh 455 20 6.7ng 6.7ng CD cord-023134-y665agnh 455 21 / / SYM cord-023134-y665agnh 455 22 ml+/-2.3 ml+/-2.3 NNP cord-023134-y665agnh 455 23 , , , cord-023134-y665agnh 455 24 p=0.14 p=0.14 NNP cord-023134-y665agnh 455 25 ) ) -RRB- cord-023134-y665agnh 455 26 . . . cord-023134-y665agnh 456 1 A a DT cord-023134-y665agnh 456 2 significant significant JJ cord-023134-y665agnh 456 3 difference difference NN cord-023134-y665agnh 456 4 was be VBD cord-023134-y665agnh 456 5 present present JJ cord-023134-y665agnh 456 6 between between IN cord-023134-y665agnh 456 7 the the DT cord-023134-y665agnh 456 8 control control NN cord-023134-y665agnh 456 9 group group NN cord-023134-y665agnh 456 10 ( ( -LRB- cord-023134-y665agnh 456 11 12.9ng 12.9ng NNP cord-023134-y665agnh 456 12 / / SYM cord-023134-y665agnh 456 13 ml+/-6.8 ml+/-6.8 NNP cord-023134-y665agnh 456 14 ) ) -RRB- cord-023134-y665agnh 456 15 and and CC cord-023134-y665agnh 456 16 both both CC cord-023134-y665agnh 456 17 the the DT cord-023134-y665agnh 456 18 HSDM HSDM NNPS cord-023134-y665agnh 456 19 ( ( -LRB- cord-023134-y665agnh 456 20 p=0.0007 p=0.0007 NNP cord-023134-y665agnh 456 21 ) ) -RRB- cord-023134-y665agnh 456 22 and and CC cord-023134-y665agnh 456 23 the the DT cord-023134-y665agnh 456 24 DMgroup DMgroup NNP cord-023134-y665agnh 456 25 ( ( -LRB- cord-023134-y665agnh 456 26 p=0.0004 p=0.0004 NN cord-023134-y665agnh 456 27 ) ) -RRB- cord-023134-y665agnh 456 28 . . . cord-023134-y665agnh 457 1 Serum serum NN cord-023134-y665agnh 457 2 ghrelin ghrelin NN cord-023134-y665agnh 457 3 concentrations concentration NNS cord-023134-y665agnh 457 4 in in IN cord-023134-y665agnh 457 5 the the DT cord-023134-y665agnh 457 6 HSDM HSDM NNP cord-023134-y665agnh 457 7 cats cat NNS cord-023134-y665agnh 457 8 undergoing undergo VBG cord-023134-y665agnh 457 9 RT RT NNP cord-023134-y665agnh 457 10 ( ( -LRB- cord-023134-y665agnh 457 11 n n NN cord-023134-y665agnh 457 12 = = SYM cord-023134-y665agnh 457 13 13 13 CD cord-023134-y665agnh 457 14 ) ) -RRB- cord-023134-y665agnh 457 15 were be VBD cord-023134-y665agnh 457 16 significantly significantly RB cord-023134-y665agnh 457 17 higher high JJR cord-023134-y665agnh 457 18 following follow VBG cord-023134-y665agnh 457 19 completion completion NN cord-023134-y665agnh 457 20 of of IN cord-023134-y665agnh 457 21 treatment treatment NN cord-023134-y665agnh 457 22 ( ( -LRB- cord-023134-y665agnh 457 23 6.7ng 6.7ng CD cord-023134-y665agnh 457 24 / / SYM cord-023134-y665agnh 457 25 ml+/-1.9 ml+/-1.9 NNP cord-023134-y665agnh 457 26 versus versus IN cord-023134-y665agnh 457 27 8.6ng 8.6ng CD cord-023134-y665agnh 457 28 / / SYM cord-023134-y665agnh 457 29 ml+/-2.2 ml+/-2.2 NNP cord-023134-y665agnh 457 30 , , , cord-023134-y665agnh 457 31 p=0.006).The p=0.006).the NN cord-023134-y665agnh 457 32 results result NNS cord-023134-y665agnh 457 33 suggest suggest VBP cord-023134-y665agnh 457 34 feline feline JJ cord-023134-y665agnh 457 35 serum serum NN cord-023134-y665agnh 457 36 total total JJ cord-023134-y665agnh 457 37 ghrelin ghrelin NN cord-023134-y665agnh 457 38 is be VBZ cord-023134-y665agnh 457 39 suppressed suppress VBN cord-023134-y665agnh 457 40 to to IN cord-023134-y665agnh 457 41 similar similar JJ cord-023134-y665agnh 457 42 levels level NNS cord-023134-y665agnh 457 43 in in IN cord-023134-y665agnh 457 44 both both CC cord-023134-y665agnh 457 45 the the DT cord-023134-y665agnh 457 46 diabetic diabetic JJ cord-023134-y665agnh 457 47 and and CC cord-023134-y665agnh 457 48 diabetic diabetic JJ cord-023134-y665agnh 457 49 hypersomatotrophic hypersomatotrophic JJ cord-023134-y665agnh 457 50 state state NN cord-023134-y665agnh 457 51 compared compare VBN cord-023134-y665agnh 457 52 to to IN cord-023134-y665agnh 457 53 healthy healthy JJ cord-023134-y665agnh 457 54 subjects subject NNS cord-023134-y665agnh 457 55 . . . cord-023134-y665agnh 458 1 Consequently consequently RB cord-023134-y665agnh 458 2 , , , cord-023134-y665agnh 458 3 it -PRON- PRP cord-023134-y665agnh 458 4 appears appear VBZ cord-023134-y665agnh 458 5 serum serum NN cord-023134-y665agnh 458 6 ghrelin ghrelin NN cord-023134-y665agnh 458 7 levels level NNS cord-023134-y665agnh 458 8 are be VBP cord-023134-y665agnh 458 9 not not RB cord-023134-y665agnh 458 10 helpful helpful JJ cord-023134-y665agnh 458 11 in in IN cord-023134-y665agnh 458 12 determining determine VBG cord-023134-y665agnh 458 13 the the DT cord-023134-y665agnh 458 14 presence presence NN cord-023134-y665agnh 458 15 of of IN cord-023134-y665agnh 458 16 HS HS NNP cord-023134-y665agnh 458 17 in in IN cord-023134-y665agnh 458 18 the the DT cord-023134-y665agnh 458 19 diabetic diabetic JJ cord-023134-y665agnh 458 20 cat cat NN cord-023134-y665agnh 458 21 . . . cord-023134-y665agnh 459 1 However however RB cord-023134-y665agnh 459 2 , , , cord-023134-y665agnh 459 3 the the DT cord-023134-y665agnh 459 4 results result NNS cord-023134-y665agnh 459 5 do do VBP cord-023134-y665agnh 459 6 indicate indicate VB cord-023134-y665agnh 459 7 treatment treatment NN cord-023134-y665agnh 459 8 of of IN cord-023134-y665agnh 459 9 HS HS NNP cord-023134-y665agnh 459 10 with with IN cord-023134-y665agnh 459 11 RT RT NNP cord-023134-y665agnh 459 12 results result NNS cord-023134-y665agnh 459 13 in in IN cord-023134-y665agnh 459 14 an an DT cord-023134-y665agnh 459 15 increase increase NN cord-023134-y665agnh 459 16 in in IN cord-023134-y665agnh 459 17 serum serum NN cord-023134-y665agnh 459 18 ghrelin ghrelin NN cord-023134-y665agnh 459 19 , , , cord-023134-y665agnh 459 20 suggesting suggest VBG cord-023134-y665agnh 459 21 the the DT cord-023134-y665agnh 459 22 presence presence NN cord-023134-y665agnh 459 23 of of IN cord-023134-y665agnh 459 24 an an DT cord-023134-y665agnh 459 25 independent independent JJ cord-023134-y665agnh 459 26 inhibitory inhibitory JJ cord-023134-y665agnh 459 27 effect effect NN cord-023134-y665agnh 459 28 of of IN cord-023134-y665agnh 459 29 excess excess JJ cord-023134-y665agnh 459 30 GH GH NNP cord-023134-y665agnh 459 31 on on IN cord-023134-y665agnh 459 32 serum serum NN cord-023134-y665agnh 459 33 ghrelin ghrelin NN cord-023134-y665agnh 459 34 production production NN cord-023134-y665agnh 459 35 . . . cord-023134-y665agnh 460 1 This this DT cord-023134-y665agnh 460 2 potential potential JJ cord-023134-y665agnh 460 3 inhibitory inhibitory JJ cord-023134-y665agnh 460 4 effect effect NN cord-023134-y665agnh 460 5 of of IN cord-023134-y665agnh 460 6 GH GH NNP cord-023134-y665agnh 460 7 might may MD cord-023134-y665agnh 460 8 render render VB cord-023134-y665agnh 460 9 serum serum NN cord-023134-y665agnh 460 10 ghrelin ghrelin NN cord-023134-y665agnh 460 11 measurement measurement NN cord-023134-y665agnh 460 12 useful useful JJ cord-023134-y665agnh 460 13 as as IN cord-023134-y665agnh 460 14 an an DT cord-023134-y665agnh 460 15 additional additional JJ cord-023134-y665agnh 460 16 tool tool NN cord-023134-y665agnh 460 17 to to TO cord-023134-y665agnh 460 18 assess assess VB cord-023134-y665agnh 460 19 hypersomatotrophic hypersomatotrophic JJ cord-023134-y665agnh 460 20 remission remission NN cord-023134-y665agnh 460 21 after after IN cord-023134-y665agnh 460 22 RT RT NNP cord-023134-y665agnh 460 23 . . . cord-023134-y665agnh 461 1 Further further JJ cord-023134-y665agnh 461 2 studies study NNS cord-023134-y665agnh 461 3 are be VBP cord-023134-y665agnh 461 4 however however RB cord-023134-y665agnh 461 5 indicated indicate VBN cord-023134-y665agnh 461 6 . . . cord-023134-y665agnh 462 1 To to IN cord-023134-y665agnh 462 2 date date NN cord-023134-y665agnh 462 3 only only RB cord-023134-y665agnh 462 4 few few JJ cord-023134-y665agnh 462 5 studies study NNS cord-023134-y665agnh 462 6 characterized characterize VBD cord-023134-y665agnh 462 7 histopathological histopathological JJ cord-023134-y665agnh 462 8 features feature NNS cord-023134-y665agnh 462 9 of of IN cord-023134-y665agnh 462 10 the the DT cord-023134-y665agnh 462 11 endocrine endocrine JJ cord-023134-y665agnh 462 12 and and CC cord-023134-y665agnh 462 13 exocrine exocrine JJ cord-023134-y665agnh 462 14 pancreas pancrea NNS cord-023134-y665agnh 462 15 in in IN cord-023134-y665agnh 462 16 cats cat NNS cord-023134-y665agnh 462 17 with with IN cord-023134-y665agnh 462 18 diabetes diabetes NN cord-023134-y665agnh 462 19 mellitus mellitus NN cord-023134-y665agnh 462 20 . . . cord-023134-y665agnh 463 1 Loss loss NN cord-023134-y665agnh 463 2 of of IN cord-023134-y665agnh 463 3 b b NN cord-023134-y665agnh 463 4 - - HYPH cord-023134-y665agnh 463 5 cells cell NNS cord-023134-y665agnh 463 6 is be VBZ cord-023134-y665agnh 463 7 a a DT cord-023134-y665agnh 463 8 consistent consistent JJ cord-023134-y665agnh 463 9 finding finding NN cord-023134-y665agnh 463 10 but but CC cord-023134-y665agnh 463 11 no no DT cord-023134-y665agnh 463 12 detailed detailed JJ cord-023134-y665agnh 463 13 data datum NNS cord-023134-y665agnh 463 14 about about IN cord-023134-y665agnh 463 15 the the DT cord-023134-y665agnh 463 16 presence presence NN cord-023134-y665agnh 463 17 and and CC cord-023134-y665agnh 463 18 types type NNS cord-023134-y665agnh 463 19 of of IN cord-023134-y665agnh 463 20 inflammatory inflammatory JJ cord-023134-y665agnh 463 21 cells cell NNS cord-023134-y665agnh 463 22 are be VBP cord-023134-y665agnh 463 23 available available JJ cord-023134-y665agnh 463 24 . . . cord-023134-y665agnh 464 1 We -PRON- PRP cord-023134-y665agnh 464 2 recently recently RB cord-023134-y665agnh 464 3 observed observe VBD cord-023134-y665agnh 464 4 that that IN cord-023134-y665agnh 464 5 hyperglycemia hyperglycemia NN cord-023134-y665agnh 464 6 increases increase VBZ cord-023134-y665agnh 464 7 neutrophils neutrophil NNS cord-023134-y665agnh 464 8 in in IN cord-023134-y665agnh 464 9 the the DT cord-023134-y665agnh 464 10 exocrine exocrine JJ cord-023134-y665agnh 464 11 pancreas pancrea NNS cord-023134-y665agnh 464 12 . . . cord-023134-y665agnh 465 1 The the DT cord-023134-y665agnh 465 2 aims aim NNS cord-023134-y665agnh 465 3 of of IN cord-023134-y665agnh 465 4 the the DT cord-023134-y665agnh 465 5 present present JJ cord-023134-y665agnh 465 6 study study NN cord-023134-y665agnh 465 7 were be VBD cord-023134-y665agnh 465 8 to to TO cord-023134-y665agnh 465 9 assess assess VB cord-023134-y665agnh 465 10 whether whether IN cord-023134-y665agnh 465 11 diabetic diabetic JJ cord-023134-y665agnh 465 12 cats cat NNS cord-023134-y665agnh 465 13 have have VBP cord-023134-y665agnh 465 14 pathological pathological JJ cord-023134-y665agnh 465 15 evidence evidence NN cord-023134-y665agnh 465 16 of of IN cord-023134-y665agnh 465 17 islet islet NN cord-023134-y665agnh 465 18 inflammation inflammation NN cord-023134-y665agnh 465 19 or or CC cord-023134-y665agnh 465 20 pancreatitis pancreatitis NN cord-023134-y665agnh 465 21 and and CC cord-023134-y665agnh 465 22 to to TO cord-023134-y665agnh 465 23 define define VB cord-023134-y665agnh 465 24 islet islet NN cord-023134-y665agnh 465 25 lesions lesion NNS cord-023134-y665agnh 465 26 in in IN cord-023134-y665agnh 465 27 comparison comparison NN cord-023134-y665agnh 465 28 to to IN cord-023134-y665agnh 465 29 a a DT cord-023134-y665agnh 465 30 well well RB cord-023134-y665agnh 465 31 - - HYPH cord-023134-y665agnh 465 32 matched match VBN cord-023134-y665agnh 465 33 control control NN cord-023134-y665agnh 465 34 population population NN cord-023134-y665agnh 465 35 . . . cord-023134-y665agnh 466 1 Formalin Formalin NNP cord-023134-y665agnh 466 2 - - HYPH cord-023134-y665agnh 466 3 fixed fix VBN cord-023134-y665agnh 466 4 , , , cord-023134-y665agnh 466 5 paraffin paraffin NN cord-023134-y665agnh 466 6 - - HYPH cord-023134-y665agnh 466 7 embedded embed VBN cord-023134-y665agnh 466 8 pancreatic pancreatic NN cord-023134-y665agnh 466 9 samples sample NNS cord-023134-y665agnh 466 10 were be VBD cord-023134-y665agnh 466 11 collected collect VBN cord-023134-y665agnh 466 12 from from IN cord-023134-y665agnh 466 13 post post JJ cord-023134-y665agnh 466 14 - - JJ cord-023134-y665agnh 466 15 mortem mortem JJ cord-023134-y665agnh 466 16 examination examination NN cord-023134-y665agnh 466 17 performed perform VBN cord-023134-y665agnh 466 18 on on IN cord-023134-y665agnh 466 19 diabetic diabetic JJ cord-023134-y665agnh 466 20 and and CC cord-023134-y665agnh 466 21 control control NN cord-023134-y665agnh 466 22 cats cat NNS cord-023134-y665agnh 466 23 died die VBD cord-023134-y665agnh 466 24 due due IN cord-023134-y665agnh 466 25 to to IN cord-023134-y665agnh 466 26 any any DT cord-023134-y665agnh 466 27 disease disease NN cord-023134-y665agnh 466 28 at at IN cord-023134-y665agnh 466 29 the the DT cord-023134-y665agnh 466 30 Clinic Clinic NNP cord-023134-y665agnh 466 31 for for IN cord-023134-y665agnh 466 32 Small Small NNP cord-023134-y665agnh 466 33 Animal Animal NNP cord-023134-y665agnh 466 34 Internal Internal NNP cord-023134-y665agnh 466 35 Medicine Medicine NNP cord-023134-y665agnh 466 36 , , , cord-023134-y665agnh 466 37 University University NNP cord-023134-y665agnh 466 38 of of IN cord-023134-y665agnh 466 39 Zurich Zurich NNP cord-023134-y665agnh 466 40 ( ( -LRB- cord-023134-y665agnh 466 41 Switzerland Switzerland NNP cord-023134-y665agnh 466 42 ) ) -RRB- cord-023134-y665agnh 466 43 between between IN cord-023134-y665agnh 466 44 1997 1997 CD cord-023134-y665agnh 466 45 and and CC cord-023134-y665agnh 466 46 2009 2009 CD cord-023134-y665agnh 466 47 . . . cord-023134-y665agnh 467 1 Control control NN cord-023134-y665agnh 467 2 cats cat NNS cord-023134-y665agnh 467 3 were be VBD cord-023134-y665agnh 467 4 selected select VBN cord-023134-y665agnh 467 5 to to TO cord-023134-y665agnh 467 6 be be VB cord-023134-y665agnh 467 7 matched match VBN cord-023134-y665agnh 467 8 for for IN cord-023134-y665agnh 467 9 age age NN cord-023134-y665agnh 467 10 , , , cord-023134-y665agnh 467 11 sex sex NN cord-023134-y665agnh 467 12 , , , cord-023134-y665agnh 467 13 breed breed NN cord-023134-y665agnh 467 14 and and CC cord-023134-y665agnh 467 15 body body NN cord-023134-y665agnh 467 16 weight weight NN cord-023134-y665agnh 467 17 . . . cord-023134-y665agnh 468 1 Sections section NNS cord-023134-y665agnh 468 2 were be VBD cord-023134-y665agnh 468 3 routinely routinely RB cord-023134-y665agnh 468 4 stained stain VBN cord-023134-y665agnh 468 5 with with IN cord-023134-y665agnh 468 6 hematoxilin hematoxilin NNP cord-023134-y665agnh 468 7 - - HYPH cord-023134-y665agnh 468 8 eosin eosin NNP cord-023134-y665agnh 468 9 , , , cord-023134-y665agnh 468 10 and and CC cord-023134-y665agnh 468 11 doublelabeled doublelabele VBN cord-023134-y665agnh 468 12 immunohistochemistry immunohistochemistry NN cord-023134-y665agnh 468 13 was be VBD cord-023134-y665agnh 468 14 performed perform VBN cord-023134-y665agnh 468 15 for for IN cord-023134-y665agnh 468 16 the the DT cord-023134-y665agnh 468 17 following following JJ cord-023134-y665agnh 468 18 markers marker NNS cord-023134-y665agnh 468 19 : : : cord-023134-y665agnh 468 20 insulin insulin NN cord-023134-y665agnh 468 21 and and CC cord-023134-y665agnh 468 22 myeloperoxidase myeloperoxidase NN cord-023134-y665agnh 468 23 ( ( -LRB- cord-023134-y665agnh 468 24 neutrophils neutrophil NNS cord-023134-y665agnh 468 25 ) ) -RRB- cord-023134-y665agnh 468 26 , , , cord-023134-y665agnh 468 27 insulin insulin NN cord-023134-y665agnh 468 28 and and CC cord-023134-y665agnh 468 29 CD3 CD3 NNP cord-023134-y665agnh 468 30 ( ( -LRB- cord-023134-y665agnh 468 31 T T NNP cord-023134-y665agnh 468 32 - - HYPH cord-023134-y665agnh 468 33 lymphocytes lymphocyte NNS cord-023134-y665agnh 468 34 ) ) -RRB- cord-023134-y665agnh 468 35 , , , cord-023134-y665agnh 468 36 insulin insulin NN cord-023134-y665agnh 468 37 and and CC cord-023134-y665agnh 468 38 CD20 cd20 NN cord-023134-y665agnh 468 39 ( ( -LRB- cord-023134-y665agnh 468 40 B b NN cord-023134-y665agnh 468 41 - - HYPH cord-023134-y665agnh 468 42 lymphocytes lymphocyte NNS cord-023134-y665agnh 468 43 ) ) -RRB- cord-023134-y665agnh 468 44 , , , cord-023134-y665agnh 468 45 insulin insulin NN cord-023134-y665agnh 468 46 and and CC cord-023134-y665agnh 468 47 PCNA PCNA NNS cord-023134-y665agnh 468 48 ( ( -LRB- cord-023134-y665agnh 468 49 proliferation proliferation NN cord-023134-y665agnh 468 50 marker marker NN cord-023134-y665agnh 468 51 ) ) -RRB- cord-023134-y665agnh 468 52 , , , cord-023134-y665agnh 468 53 and and CC cord-023134-y665agnh 468 54 glucagon glucagon NN cord-023134-y665agnh 468 55 and and CC cord-023134-y665agnh 468 56 Ki-67 Ki-67 NNP cord-023134-y665agnh 468 57 ( ( -LRB- cord-023134-y665agnh 468 58 proliferation proliferation NN cord-023134-y665agnh 468 59 marker marker NN cord-023134-y665agnh 468 60 ) ) -RRB- cord-023134-y665agnh 468 61 . . . cord-023134-y665agnh 469 1 Light light JJ cord-023134-y665agnh 469 2 - - HYPH cord-023134-y665agnh 469 3 microscopic microscopic JJ cord-023134-y665agnh 469 4 cell cell NN cord-023134-y665agnh 469 5 counting counting NN cord-023134-y665agnh 469 6 and and CC cord-023134-y665agnh 469 7 morphometric morphometric JJ cord-023134-y665agnh 469 8 analyses analysis NNS cord-023134-y665agnh 469 9 were be VBD cord-023134-y665agnh 469 10 performed perform VBN cord-023134-y665agnh 469 11 manually manually RB cord-023134-y665agnh 469 12 and and CC cord-023134-y665agnh 469 13 with with IN cord-023134-y665agnh 469 14 software software NN cord-023134-y665agnh 470 1 ( ( -LRB- cord-023134-y665agnh 470 2 Image image NN cord-023134-y665agnh 470 3 - - HYPH cord-023134-y665agnh 470 4 J J NNP cord-023134-y665agnh 470 5 ) ) -RRB- cord-023134-y665agnh 470 6 , , , cord-023134-y665agnh 470 7 respectively respectively RB cord-023134-y665agnh 470 8 . . . cord-023134-y665agnh 471 1 Data datum NNS cord-023134-y665agnh 471 2 were be VBD cord-023134-y665agnh 471 3 analyzed analyze VBN cord-023134-y665agnh 471 4 with with IN cord-023134-y665agnh 471 5 contingency contingency NN cord-023134-y665agnh 471 6 tables table NNS cord-023134-y665agnh 471 7 and and CC cord-023134-y665agnh 471 8 ttests ttest NNS cord-023134-y665agnh 471 9 . . . cord-023134-y665agnh 472 1 Thirty thirty CD cord-023134-y665agnh 472 2 - - HYPH cord-023134-y665agnh 472 3 seven seven CD cord-023134-y665agnh 472 4 diabetic diabetic JJ cord-023134-y665agnh 472 5 cats cat NNS cord-023134-y665agnh 472 6 and and CC cord-023134-y665agnh 472 7 20 20 CD cord-023134-y665agnh 472 8 controls control NNS cord-023134-y665agnh 472 9 were be VBD cord-023134-y665agnh 472 10 included include VBN cord-023134-y665agnh 472 11 . . . cord-023134-y665agnh 473 1 The the DT cord-023134-y665agnh 473 2 mean mean JJ cord-023134-y665agnh 473 3 insulin insulin NN cord-023134-y665agnh 473 4 - - HYPH cord-023134-y665agnh 473 5 positive positive JJ cord-023134-y665agnh 473 6 cross cross JJ cord-023134-y665agnh 473 7 sectional sectional JJ cord-023134-y665agnh 473 8 area area NN cord-023134-y665agnh 473 9 was be VBD cord-023134-y665agnh 473 10 approximately approximately RB cord-023134-y665agnh 473 11 40 40 CD cord-023134-y665agnh 473 12 % % NN cord-023134-y665agnh 473 13 lower low JJR cord-023134-y665agnh 473 14 in in IN cord-023134-y665agnh 473 15 diabetic diabetic NN cord-023134-y665agnh 473 16 than than IN cord-023134-y665agnh 473 17 control control NN cord-023134-y665agnh 473 18 cats cat NNS cord-023134-y665agnh 473 19 ( ( -LRB- cord-023134-y665agnh 473 20 P<0.01 P<0.01 NNP cord-023134-y665agnh 473 21 ) ) -RRB- cord-023134-y665agnh 473 22 , , , cord-023134-y665agnh 473 23 that that DT cord-023134-y665agnh 473 24 of of IN cord-023134-y665agnh 473 25 glucagon glucagon NN cord-023134-y665agnh 473 26 was be VBD cord-023134-y665agnh 473 27 similar similar JJ cord-023134-y665agnh 473 28 . . . cord-023134-y665agnh 474 1 Proliferation proliferation NN cord-023134-y665agnh 474 2 of of IN cord-023134-y665agnh 474 3 insulin insulin NN cord-023134-y665agnh 474 4 - - HYPH cord-023134-y665agnh 474 5 positive positive JJ cord-023134-y665agnh 474 6 and and CC cord-023134-y665agnh 474 7 glucagon glucagon NN cord-023134-y665agnh 474 8 - - HYPH cord-023134-y665agnh 474 9 positive positive JJ cord-023134-y665agnh 474 10 cells cell NNS cord-023134-y665agnh 474 11 and and CC cord-023134-y665agnh 474 12 the the DT cord-023134-y665agnh 474 13 average average JJ cord-023134-y665agnh 474 14 counts count NNS cord-023134-y665agnh 474 15 of of IN cord-023134-y665agnh 474 16 neutrophils neutrophil NNS cord-023134-y665agnh 474 17 , , , cord-023134-y665agnh 474 18 T T NNP cord-023134-y665agnh 474 19 - - HYPH cord-023134-y665agnh 474 20 and and CC cord-023134-y665agnh 474 21 B b NN cord-023134-y665agnh 474 22 - - HYPH cord-023134-y665agnh 474 23 lymphocytes lymphocyte NNS cord-023134-y665agnh 474 24 in in IN cord-023134-y665agnh 474 25 the the DT cord-023134-y665agnh 474 26 islets islet NNS cord-023134-y665agnh 474 27 did do VBD cord-023134-y665agnh 474 28 not not RB cord-023134-y665agnh 474 29 differ differ VB cord-023134-y665agnh 474 30 between between IN cord-023134-y665agnh 474 31 groups group NNS cord-023134-y665agnh 474 32 . . . cord-023134-y665agnh 475 1 Interestingly interestingly RB cord-023134-y665agnh 475 2 , , , cord-023134-y665agnh 475 3 the the DT cord-023134-y665agnh 475 4 presence presence NN cord-023134-y665agnh 475 5 of of IN cord-023134-y665agnh 475 6 ( ( -LRB- cord-023134-y665agnh 475 7 T T NNP cord-023134-y665agnh 475 8 and and CC cord-023134-y665agnh 475 9 B B NNP cord-023134-y665agnh 475 10 ) ) -RRB- cord-023134-y665agnh 475 11 lymphocytes lymphocyte NNS cord-023134-y665agnh 475 12 in in IN cord-023134-y665agnh 475 13 general general JJ cord-023134-y665agnh 475 14 tended tend VBD cord-023134-y665agnh 475 15 to to TO cord-023134-y665agnh 475 16 be be VB cord-023134-y665agnh 475 17 more more RBR cord-023134-y665agnh 475 18 frequent frequent JJ cord-023134-y665agnh 475 19 in in IN cord-023134-y665agnh 475 20 diabetic diabetic JJ cord-023134-y665agnh 475 21 ( ( -LRB- cord-023134-y665agnh 475 22 8/37=21.6 8/37=21.6 CD cord-023134-y665agnh 475 23 % % NN cord-023134-y665agnh 475 24 ) ) -RRB- cord-023134-y665agnh 475 25 than than IN cord-023134-y665agnh 475 26 control control NN cord-023134-y665agnh 475 27 ( ( -LRB- cord-023134-y665agnh 475 28 1/20=5.0 1/20=5.0 CD cord-023134-y665agnh 475 29 % % NN cord-023134-y665agnh 475 30 ) ) -RRB- cord-023134-y665agnh 475 31 cats cat NNS cord-023134-y665agnh 475 32 . . . cord-023134-y665agnh 476 1 In in IN cord-023134-y665agnh 476 2 the the DT cord-023134-y665agnh 476 3 exocrine exocrine JJ cord-023134-y665agnh 476 4 pancreas pancrea NNS cord-023134-y665agnh 476 5 , , , cord-023134-y665agnh 476 6 a a DT cord-023134-y665agnh 476 7 trend trend NN cord-023134-y665agnh 476 8 towards towards IN cord-023134-y665agnh 476 9 increased increase VBN cord-023134-y665agnh 476 10 presence presence NN cord-023134-y665agnh 476 11 of of IN cord-023134-y665agnh 476 12 necrosis necrosis NN cord-023134-y665agnh 476 13 and and CC cord-023134-y665agnh 476 14 fibrosis fibrosis NN cord-023134-y665agnh 476 15 was be VBD cord-023134-y665agnh 476 16 observed observe VBN cord-023134-y665agnh 476 17 in in IN cord-023134-y665agnh 476 18 diabetic diabetic JJ cord-023134-y665agnh 476 19 cats cat NNS cord-023134-y665agnh 476 20 ( ( -LRB- cord-023134-y665agnh 476 21 6/37=16.2 6/37=16.2 CD cord-023134-y665agnh 476 22 % % NN cord-023134-y665agnh 476 23 vs. vs. CC cord-023134-y665agnh 476 24 0/20=0 0/20=0 CD cord-023134-y665agnh 476 25 % % NN cord-023134-y665agnh 476 26 ; ; : cord-023134-y665agnh 476 27 P=0.07 P=0.07 NNP cord-023134-y665agnh 476 28 ) ) -RRB- cord-023134-y665agnh 476 29 but but CC cord-023134-y665agnh 476 30 inflammatory inflammatory JJ cord-023134-y665agnh 476 31 infiltration infiltration NN cord-023134-y665agnh 476 32 did do VBD cord-023134-y665agnh 476 33 not not RB cord-023134-y665agnh 476 34 differ differ VB cord-023134-y665agnh 476 35 . . . cord-023134-y665agnh 477 1 Proliferation proliferation NN cord-023134-y665agnh 477 2 of of IN cord-023134-y665agnh 477 3 acinar acinar JJ cord-023134-y665agnh 477 4 cells cell NNS cord-023134-y665agnh 477 5 was be VBD cord-023134-y665agnh 477 6 3-fold 3-fold CD cord-023134-y665agnh 477 7 increased increase VBD cord-023134-y665agnh 477 8 in in IN cord-023134-y665agnh 477 9 diabetic diabetic JJ cord-023134-y665agnh 477 10 cats cat NNS cord-023134-y665agnh 477 11 ( ( -LRB- cord-023134-y665agnh 477 12 P<0.01 P<0.01 NNP cord-023134-y665agnh 477 13 ) ) -RRB- cord-023134-y665agnh 477 14 , , , cord-023134-y665agnh 477 15 notably notably RB cord-023134-y665agnh 477 16 nearby nearby JJ cord-023134-y665agnh 477 17 islets islet NNS cord-023134-y665agnh 477 18 ( ( -LRB- cord-023134-y665agnh 477 19 6-fold 6-fold CD cord-023134-y665agnh 478 1 , , , cord-023134-y665agnh 478 2 P<0.001).The P<0.001).The NNP cord-023134-y665agnh 478 3 results result NNS cord-023134-y665agnh 478 4 confirm confirm VBP cord-023134-y665agnh 478 5 previous previous JJ cord-023134-y665agnh 478 6 observations observation NNS cord-023134-y665agnh 478 7 that that WDT cord-023134-y665agnh 478 8 loss loss NN cord-023134-y665agnh 478 9 of of IN cord-023134-y665agnh 478 10 b b NN cord-023134-y665agnh 478 11 - - HYPH cord-023134-y665agnh 478 12 cells cell NNS cord-023134-y665agnh 478 13 occurs occur VBZ cord-023134-y665agnh 478 14 in in IN cord-023134-y665agnh 478 15 diabetic diabetic JJ cord-023134-y665agnh 478 16 cats cat NNS cord-023134-y665agnh 478 17 . . . cord-023134-y665agnh 479 1 In in IN cord-023134-y665agnh 479 2 addition addition NN cord-023134-y665agnh 479 3 , , , cord-023134-y665agnh 479 4 a a DT cord-023134-y665agnh 479 5 subset subset NN cord-023134-y665agnh 479 6 of of IN cord-023134-y665agnh 479 7 diabetic diabetic JJ cord-023134-y665agnh 479 8 cats cat NNS cord-023134-y665agnh 479 9 shows show VBZ cord-023134-y665agnh 479 10 lymphocytic lymphocytic JJ cord-023134-y665agnh 479 11 infiltration infiltration NN cord-023134-y665agnh 479 12 of of IN cord-023134-y665agnh 479 13 the the DT cord-023134-y665agnh 479 14 islets islet NNS cord-023134-y665agnh 479 15 that that WDT cord-023134-y665agnh 479 16 might may MD cord-023134-y665agnh 479 17 have have VB cord-023134-y665agnh 479 18 contributed contribute VBN cord-023134-y665agnh 479 19 to to IN cord-023134-y665agnh 479 20 b b NN cord-023134-y665agnh 479 21 - - HYPH cord-023134-y665agnh 479 22 cell cell NN cord-023134-y665agnh 479 23 loss loss NN cord-023134-y665agnh 479 24 . . . cord-023134-y665agnh 480 1 Increased increase VBN cord-023134-y665agnh 480 2 necrosis necrosis NN cord-023134-y665agnh 480 3 and and CC cord-023134-y665agnh 480 4 fibrosis fibrosis NN cord-023134-y665agnh 480 5 of of IN cord-023134-y665agnh 480 6 the the DT cord-023134-y665agnh 480 7 exocrine exocrine JJ cord-023134-y665agnh 480 8 tissue tissue NN cord-023134-y665agnh 480 9 may may MD cord-023134-y665agnh 480 10 suggests suggest VBZ cord-023134-y665agnh 480 11 that that IN cord-023134-y665agnh 480 12 the the DT cord-023134-y665agnh 480 13 diabetes diabetes NN cord-023134-y665agnh 480 14 leads lead VBZ cord-023134-y665agnh 480 15 to to IN cord-023134-y665agnh 480 16 pancreatitis pancreatitis NN cord-023134-y665agnh 480 17 in in IN cord-023134-y665agnh 480 18 some some DT cord-023134-y665agnh 480 19 cats cat NNS cord-023134-y665agnh 480 20 . . . cord-023134-y665agnh 481 1 The the DT cord-023134-y665agnh 481 2 increased increase VBN cord-023134-y665agnh 481 3 proliferation proliferation NN cord-023134-y665agnh 481 4 rate rate NN cord-023134-y665agnh 481 5 of of IN cord-023134-y665agnh 481 6 acinar acinar JJ cord-023134-y665agnh 481 7 cells cell NNS cord-023134-y665agnh 481 8 deserves deserve VBZ cord-023134-y665agnh 481 9 further further JJ cord-023134-y665agnh 481 10 investigation investigation NN cord-023134-y665agnh 481 11 . . . cord-023134-y665agnh 482 1 In in IN cord-023134-y665agnh 482 2 humans human NNS cord-023134-y665agnh 482 3 this this DT cord-023134-y665agnh 482 4 finding finding NN cord-023134-y665agnh 482 5 has have VBZ cord-023134-y665agnh 482 6 been be VBN cord-023134-y665agnh 482 7 associated associate VBN cord-023134-y665agnh 482 8 with with IN cord-023134-y665agnh 482 9 chronic chronic JJ cord-023134-y665agnh 482 10 pancreatitis pancreatitis NN cord-023134-y665agnh 482 11 as as RB cord-023134-y665agnh 482 12 well well RB cord-023134-y665agnh 482 13 as as IN cord-023134-y665agnh 482 14 transdifferentiation transdifferentiation NN cord-023134-y665agnh 482 15 into into IN cord-023134-y665agnh 482 16 islet islet NN cord-023134-y665agnh 482 17 cells cell NNS cord-023134-y665agnh 482 18 . . . cord-023134-y665agnh 483 1 On on IN cord-023134-y665agnh 483 2 the the DT cord-023134-y665agnh 483 3 basis basis NN cord-023134-y665agnh 483 4 of of IN cord-023134-y665agnh 483 5 a a DT cord-023134-y665agnh 483 6 relatively relatively RB cord-023134-y665agnh 483 7 high high JJ cord-023134-y665agnh 483 8 prevalence prevalence NN cord-023134-y665agnh 483 9 of of IN cord-023134-y665agnh 483 10 hypersomatotropism hypersomatotropism NN cord-023134-y665agnh 483 11 ( ( -LRB- cord-023134-y665agnh 483 12 HS HS NNP cord-023134-y665agnh 483 13 ) ) -RRB- cord-023134-y665agnh 483 14 amongst amongst IN cord-023134-y665agnh 483 15 cats cat NNS cord-023134-y665agnh 483 16 with with IN cord-023134-y665agnh 483 17 a a DT cord-023134-y665agnh 483 18 diagnosis diagnosis NN cord-023134-y665agnh 483 19 of of IN cord-023134-y665agnh 483 20 diabetes diabetes NN cord-023134-y665agnh 483 21 mellitus mellitus NN cord-023134-y665agnh 483 22 , , , cord-023134-y665agnh 483 23 as as RB cord-023134-y665agnh 483 24 well well RB cord-023134-y665agnh 483 25 as as IN cord-023134-y665agnh 483 26 the the DT cord-023134-y665agnh 483 27 possible possible JJ cord-023134-y665agnh 483 28 subtle subtle JJ cord-023134-y665agnh 483 29 phenotype phenotype NN cord-023134-y665agnh 483 30 of of IN cord-023134-y665agnh 483 31 these these DT cord-023134-y665agnh 483 32 patients patient NNS cord-023134-y665agnh 483 33 and and CC cord-023134-y665agnh 483 34 the the DT cord-023134-y665agnh 483 35 significant significant JJ cord-023134-y665agnh 483 36 implications implication NNS cord-023134-y665agnh 483 37 on on IN cord-023134-y665agnh 483 38 prognosis prognosis NN cord-023134-y665agnh 483 39 and and CC cord-023134-y665agnh 483 40 treatment treatment NN cord-023134-y665agnh 483 41 , , , cord-023134-y665agnh 483 42 screening screen VBG cord-023134-y665agnh 483 43 diabetic diabetic JJ cord-023134-y665agnh 483 44 cats cat NNS cord-023134-y665agnh 483 45 for for IN cord-023134-y665agnh 483 46 HS HS NNP cord-023134-y665agnh 483 47 could could MD cord-023134-y665agnh 483 48 be be VB cord-023134-y665agnh 483 49 advocated advocate VBN cord-023134-y665agnh 483 50 . . . cord-023134-y665agnh 484 1 For for IN cord-023134-y665agnh 484 2 most most JJS cord-023134-y665agnh 484 3 veterinarians veterinarian NNS cord-023134-y665agnh 484 4 serum serum VBP cord-023134-y665agnh 484 5 total total JJ cord-023134-y665agnh 484 6 insulin insulin NN cord-023134-y665agnh 484 7 - - HYPH cord-023134-y665agnh 484 8 like like JJ cord-023134-y665agnh 484 9 growth growth NN cord-023134-y665agnh 484 10 factor-1 factor-1 NNP cord-023134-y665agnh 484 11 ( ( -LRB- cord-023134-y665agnh 484 12 IGF-1 IGF-1 NNP cord-023134-y665agnh 484 13 ) ) -RRB- cord-023134-y665agnh 484 14 assessment assessment NN cord-023134-y665agnh 484 15 represents represent VBZ cord-023134-y665agnh 484 16 the the DT cord-023134-y665agnh 484 17 most most RBS cord-023134-y665agnh 484 18 feasible feasible JJ cord-023134-y665agnh 484 19 and and CC cord-023134-y665agnh 484 20 accessible accessible JJ cord-023134-y665agnh 484 21 means mean NNS cord-023134-y665agnh 484 22 of of IN cord-023134-y665agnh 484 23 performing perform VBG cord-023134-y665agnh 484 24 screening screening NN cord-023134-y665agnh 484 25 . . . cord-023134-y665agnh 485 1 However however RB cord-023134-y665agnh 485 2 , , , cord-023134-y665agnh 485 3 hepatic hepatic JJ cord-023134-y665agnh 485 4 IGF-1 IGF-1 NNP cord-023134-y665agnh 485 5 production production NN cord-023134-y665agnh 485 6 is be VBZ cord-023134-y665agnh 485 7 dependent dependent JJ cord-023134-y665agnh 485 8 on on IN cord-023134-y665agnh 485 9 presence presence NN cord-023134-y665agnh 485 10 of of IN cord-023134-y665agnh 485 11 sufficient sufficient JJ cord-023134-y665agnh 485 12 portal portal JJ cord-023134-y665agnh 485 13 insulin insulin NN cord-023134-y665agnh 485 14 , , , cord-023134-y665agnh 485 15 which which WDT cord-023134-y665agnh 485 16 can can MD cord-023134-y665agnh 485 17 be be VB cord-023134-y665agnh 485 18 deficient deficient JJ cord-023134-y665agnh 485 19 in in IN cord-023134-y665agnh 485 20 newly newly RB cord-023134-y665agnh 485 21 diagnosed diagnose VBN cord-023134-y665agnh 485 22 diabetic diabetic JJ cord-023134-y665agnh 485 23 cats cat NNS cord-023134-y665agnh 485 24 , , , cord-023134-y665agnh 485 25 resulting result VBG cord-023134-y665agnh 485 26 in in IN cord-023134-y665agnh 485 27 false false JJ cord-023134-y665agnh 485 28 negative negative JJ cord-023134-y665agnh 485 29 results result NNS cord-023134-y665agnh 485 30 . . . cord-023134-y665agnh 486 1 Additionally additionally RB cord-023134-y665agnh 486 2 , , , cord-023134-y665agnh 486 3 elevation elevation NN cord-023134-y665agnh 486 4 of of IN cord-023134-y665agnh 486 5 IGF-1 IGF-1 NNP cord-023134-y665agnh 486 6 has have VBZ cord-023134-y665agnh 486 7 been be VBN cord-023134-y665agnh 486 8 reported report VBN cord-023134-y665agnh 486 9 in in IN cord-023134-y665agnh 486 10 non non JJ cord-023134-y665agnh 486 11 - - JJ cord-023134-y665agnh 486 12 acromegalic acromegalic JJ cord-023134-y665agnh 486 13 diabetic diabetic JJ cord-023134-y665agnh 486 14 cats cat NNS cord-023134-y665agnh 486 15 . . . cord-023134-y665agnh 487 1 Alternative alternative JJ cord-023134-y665agnh 487 2 or or CC cord-023134-y665agnh 487 3 additional additional JJ cord-023134-y665agnh 487 4 diagnostic diagnostic JJ cord-023134-y665agnh 487 5 tests test NNS cord-023134-y665agnh 487 6 for for IN cord-023134-y665agnh 487 7 HS HS NNP cord-023134-y665agnh 487 8 , , , cord-023134-y665agnh 487 9 as as RB cord-023134-y665agnh 487 10 well well RB cord-023134-y665agnh 487 11 as as IN cord-023134-y665agnh 487 12 to to TO cord-023134-y665agnh 487 13 evaluate evaluate VB cord-023134-y665agnh 487 14 the the DT cord-023134-y665agnh 487 15 success success NN cord-023134-y665agnh 487 16 of of IN cord-023134-y665agnh 487 17 treatment treatment NN cord-023134-y665agnh 487 18 of of IN cord-023134-y665agnh 487 19 HS HS NNP cord-023134-y665agnh 487 20 , , , cord-023134-y665agnh 487 21 are be VBP cord-023134-y665agnh 487 22 therefore therefore RB cord-023134-y665agnh 487 23 desirable desirable JJ cord-023134-y665agnh 487 24 . . . cord-023134-y665agnh 488 1 Since since IN cord-023134-y665agnh 488 2 feline feline JJ cord-023134-y665agnh 488 3 HS HS NNP cord-023134-y665agnh 488 4 is be VBZ cord-023134-y665agnh 488 5 associated associate VBN cord-023134-y665agnh 488 6 with with IN cord-023134-y665agnh 488 7 tissue tissue NN cord-023134-y665agnh 488 8 growth growth NN cord-023134-y665agnh 488 9 , , , cord-023134-y665agnh 488 10 serum serum NN cord-023134-y665agnh 488 11 type type NN cord-023134-y665agnh 488 12 III III NNP cord-023134-y665agnh 488 13 procollagen procollagen NNP cord-023134-y665agnh 488 14 propeptide propeptide NN cord-023134-y665agnh 488 15 ( ( -LRB- cord-023134-y665agnh 488 16 PIIIP PIIIP NNP cord-023134-y665agnh 488 17 ) ) -RRB- cord-023134-y665agnh 488 18 , , , cord-023134-y665agnh 488 19 a a DT cord-023134-y665agnh 488 20 peripheral peripheral JJ cord-023134-y665agnh 488 21 indicator indicator NN cord-023134-y665agnh 488 22 of of IN cord-023134-y665agnh 488 23 collagen collagen NN cord-023134-y665agnh 488 24 turnover turnover NN cord-023134-y665agnh 488 25 , , , cord-023134-y665agnh 488 26 was be VBD cord-023134-y665agnh 488 27 hypothesised hypothesise VBN cord-023134-y665agnh 488 28 to to TO cord-023134-y665agnh 488 29 be be VB cord-023134-y665agnh 488 30 a a DT cord-023134-y665agnh 488 31 useful useful JJ cord-023134-y665agnh 488 32 indicator indicator NN cord-023134-y665agnh 488 33 of of IN cord-023134-y665agnh 488 34 active active JJ cord-023134-y665agnh 488 35 disease disease NN cord-023134-y665agnh 488 36 or or CC cord-023134-y665agnh 488 37 growth growth NN cord-023134-y665agnh 488 38 hormone hormone NN cord-023134-y665agnh 488 39 bioactivity bioactivity NN cord-023134-y665agnh 488 40 . . . cord-023134-y665agnh 489 1 Fasted fast VBN cord-023134-y665agnh 489 2 , , , cord-023134-y665agnh 489 3 pre pre JJ cord-023134-y665agnh 489 4 - - JJ cord-023134-y665agnh 489 5 insulin insulin JJ cord-023134-y665agnh 489 6 , , , cord-023134-y665agnh 489 7 serum serum NN cord-023134-y665agnh 489 8 samples sample NNS cord-023134-y665agnh 489 9 were be VBD cord-023134-y665agnh 489 10 prospectively prospectively RB cord-023134-y665agnh 489 11 collected collect VBN cord-023134-y665agnh 489 12 from from IN cord-023134-y665agnh 489 13 16 16 CD cord-023134-y665agnh 489 14 uncomplicated uncomplicated JJ cord-023134-y665agnh 489 15 diabetic diabetic JJ cord-023134-y665agnh 489 16 ( ( -LRB- cord-023134-y665agnh 489 17 DM DM NNP cord-023134-y665agnh 489 18 ) ) -RRB- cord-023134-y665agnh 489 19 and and CC cord-023134-y665agnh 489 20 16 16 CD cord-023134-y665agnh 489 21 hypersomatotrophic hypersomatotrophic NN cord-023134-y665agnh 489 22 diabetic diabetic JJ cord-023134-y665agnh 489 23 ( ( -LRB- cord-023134-y665agnh 489 24 HSDM HSDM NNP cord-023134-y665agnh 489 25 ) ) -RRB- cord-023134-y665agnh 489 26 cats cat NNS cord-023134-y665agnh 489 27 . . . cord-023134-y665agnh 490 1 Cats cat NNS cord-023134-y665agnh 490 2 were be VBD cord-023134-y665agnh 490 3 categorised categorise VBN cord-023134-y665agnh 490 4 into into IN cord-023134-y665agnh 490 5 the the DT cord-023134-y665agnh 490 6 HSDM HSDM NNP cord-023134-y665agnh 490 7 - - HYPH cord-023134-y665agnh 490 8 group group NN cord-023134-y665agnh 490 9 on on IN cord-023134-y665agnh 490 10 the the DT cord-023134-y665agnh 490 11 basis basis NN cord-023134-y665agnh 490 12 of of IN cord-023134-y665agnh 490 13 elevated elevated JJ cord-023134-y665agnh 490 14 IGF-1 IGF-1 NNP cord-023134-y665agnh 490 15 ( ( -LRB- cord-023134-y665agnh 490 16 radioimmunoassay radioimmunoassay JJ cord-023134-y665agnh 490 17 , , , cord-023134-y665agnh 490 18 > > XX cord-023134-y665agnh 490 19 1000 1000 CD cord-023134-y665agnh 490 20 ng ng NN cord-023134-y665agnh 490 21 / / SYM cord-023134-y665agnh 490 22 ml ml NN cord-023134-y665agnh 490 23 ) ) -RRB- cord-023134-y665agnh 490 24 , , , cord-023134-y665agnh 490 25 followed follow VBN cord-023134-y665agnh 490 26 by by IN cord-023134-y665agnh 490 27 demonstration demonstration NN cord-023134-y665agnh 490 28 of of IN cord-023134-y665agnh 490 29 a a DT cord-023134-y665agnh 490 30 pituitary pituitary JJ cord-023134-y665agnh 490 31 lesion lesion NN cord-023134-y665agnh 490 32 on on IN cord-023134-y665agnh 490 33 intracranial intracranial JJ cord-023134-y665agnh 490 34 imaging imaging NN cord-023134-y665agnh 490 35 and and CC cord-023134-y665agnh 490 36 into into IN cord-023134-y665agnh 490 37 the the DT cord-023134-y665agnh 490 38 DM dm NN cord-023134-y665agnh 490 39 - - HYPH cord-023134-y665agnh 490 40 group group NN cord-023134-y665agnh 490 41 on on IN cord-023134-y665agnh 490 42 the the DT cord-023134-y665agnh 490 43 basis basis NN cord-023134-y665agnh 490 44 of of IN cord-023134-y665agnh 490 45 low low JJ cord-023134-y665agnh 490 46 IGF-1 IGF-1 NNP cord-023134-y665agnh 490 47 ( ( -LRB- cord-023134-y665agnh 490 48 < < XX cord-023134-y665agnh 490 49 600 600 CD cord-023134-y665agnh 490 50 ng ng NN cord-023134-y665agnh 490 51 / / SYM cord-023134-y665agnh 490 52 ml ml NN cord-023134-y665agnh 490 53 ) ) -RRB- cord-023134-y665agnh 490 54 and and CC cord-023134-y665agnh 490 55 modest modest JJ cord-023134-y665agnh 490 56 insulin insulin NN cord-023134-y665agnh 490 57 requirements requirement NNS cord-023134-y665agnh 490 58 ( ( -LRB- cord-023134-y665agnh 490 59 < < NNP cord-023134-y665agnh 490 60 1.5 1.5 CD cord-023134-y665agnh 490 61 iu iu NNP cord-023134-y665agnh 490 62 / / SYM cord-023134-y665agnh 490 63 kg kg NNP cord-023134-y665agnh 490 64 ) ) -RRB- cord-023134-y665agnh 490 65 . . . cord-023134-y665agnh 491 1 An an DT cord-023134-y665agnh 491 2 ELISA ELISA NNP cord-023134-y665agnh 491 3 system system NN cord-023134-y665agnh 491 4 for for IN cord-023134-y665agnh 491 5 PIIIP PIIIP NNP cord-023134-y665agnh 491 6 was be VBD cord-023134-y665agnh 491 7 developed develop VBN cord-023134-y665agnh 491 8 for for IN cord-023134-y665agnh 491 9 use use NN cord-023134-y665agnh 491 10 in in IN cord-023134-y665agnh 491 11 the the DT cord-023134-y665agnh 491 12 cat cat NN cord-023134-y665agnh 491 13 . . . cord-023134-y665agnh 492 1 Data datum NNS cord-023134-y665agnh 492 2 were be VBD cord-023134-y665agnh 492 3 tested test VBN cord-023134-y665agnh 492 4 for for IN cord-023134-y665agnh 492 5 normality normality NN cord-023134-y665agnh 492 6 and and CC cord-023134-y665agnh 492 7 concentrations concentration NNS cord-023134-y665agnh 492 8 compared compare VBN cord-023134-y665agnh 492 9 using use VBG cord-023134-y665agnh 492 10 the the DT cord-023134-y665agnh 492 11 Mann Mann NNP cord-023134-y665agnh 492 12 Whitney Whitney NNP cord-023134-y665agnh 492 13 test test NN cord-023134-y665agnh 492 14 . . . cord-023134-y665agnh 493 1 Correlation correlation NN cord-023134-y665agnh 493 2 with with IN cord-023134-y665agnh 493 3 serum serum NN cord-023134-y665agnh 493 4 IGF-1 IGF-1 NNP cord-023134-y665agnh 493 5 was be VBD cord-023134-y665agnh 493 6 assessed assess VBN cord-023134-y665agnh 493 7 by by IN cord-023134-y665agnh 493 8 calculating calculate VBG cord-023134-y665agnh 493 9 a a DT cord-023134-y665agnh 493 10 Spearman Spearman NNP cord-023134-y665agnh 493 11 's 's POS cord-023134-y665agnh 493 12 correlation correlation NN cord-023134-y665agnh 493 13 coefficient coefficient NN cord-023134-y665agnh 493 14 ( ( -LRB- cord-023134-y665agnh 493 15 rho).Dilutional rho).dilutional JJ cord-023134-y665agnh 493 16 parallelism parallelism NN cord-023134-y665agnh 493 17 using use VBG cord-023134-y665agnh 493 18 cat cat NN cord-023134-y665agnh 493 19 serum serum NN cord-023134-y665agnh 493 20 with with IN cord-023134-y665agnh 493 21 high high JJ cord-023134-y665agnh 493 22 and and CC cord-023134-y665agnh 493 23 low low JJ cord-023134-y665agnh 493 24 PIIIP piiip NN cord-023134-y665agnh 493 25 - - HYPH cord-023134-y665agnh 493 26 activity activity NN cord-023134-y665agnh 493 27 indicated indicate VBD cord-023134-y665agnh 493 28 validity validity NN cord-023134-y665agnh 493 29 of of IN cord-023134-y665agnh 493 30 the the DT cord-023134-y665agnh 493 31 ELISA ELISA NNP cord-023134-y665agnh 493 32 system system NN cord-023134-y665agnh 493 33 . . . cord-023134-y665agnh 494 1 Intra intra JJ cord-023134-y665agnh 494 2 - - JJ cord-023134-y665agnh 494 3 assay assay JJ cord-023134-y665agnh 494 4 coefficient coefficient NN cord-023134-y665agnh 494 5 of of IN cord-023134-y665agnh 494 6 variation variation NN cord-023134-y665agnh 494 7 calculation calculation NN cord-023134-y665agnh 494 8 proved prove VBD cord-023134-y665agnh 494 9 adequate adequate JJ cord-023134-y665agnh 494 10 precision precision NN cord-023134-y665agnh 494 11 at at IN cord-023134-y665agnh 494 12 high high JJ cord-023134-y665agnh 494 13 and and CC cord-023134-y665agnh 494 14 low low JJ cord-023134-y665agnh 494 15 concentrations concentration NNS cord-023134-y665agnh 494 16 ( ( -LRB- cord-023134-y665agnh 494 17 7.3 7.3 CD cord-023134-y665agnh 494 18 % % NN cord-023134-y665agnh 494 19 and and CC cord-023134-y665agnh 494 20 7.8 7.8 CD cord-023134-y665agnh 494 21 % % NN cord-023134-y665agnh 494 22 ) ) -RRB- cord-023134-y665agnh 494 23 and and CC cord-023134-y665agnh 494 24 the the DT cord-023134-y665agnh 494 25 assay assay NN cord-023134-y665agnh 494 26 detection detection NN cord-023134-y665agnh 494 27 limit limit NN cord-023134-y665agnh 494 28 was be VBD cord-023134-y665agnh 494 29 found find VBN cord-023134-y665agnh 494 30 to to TO cord-023134-y665agnh 494 31 be be VB cord-023134-y665agnh 494 32 2.7 2.7 CD cord-023134-y665agnh 494 33 ng ng NN cord-023134-y665agnh 494 34 / / SYM cord-023134-y665agnh 494 35 ml ml NN cord-023134-y665agnh 494 36 . . . cord-023134-y665agnh 495 1 Median median JJ cord-023134-y665agnh 495 2 serum serum NN cord-023134-y665agnh 495 3 PIIIP PIIIP NNP cord-023134-y665agnh 495 4 was be VBD cord-023134-y665agnh 495 5 24.3 24.3 CD cord-023134-y665agnh 495 6 ng ng NN cord-023134-y665agnh 495 7 / / SYM cord-023134-y665agnh 495 8 ml ml NN cord-023134-y665agnh 496 1 ( ( -LRB- cord-023134-y665agnh 496 2 range range NN cord-023134-y665agnh 496 3 : : : cord-023134-y665agnh 496 4 < < XX cord-023134-y665agnh 496 5 2.7 2.7 CD cord-023134-y665agnh 496 6 - - HYPH cord-023134-y665agnh 496 7 44.7 44.7 CD cord-023134-y665agnh 496 8 ) ) -RRB- cord-023134-y665agnh 496 9 in in IN cord-023134-y665agnh 496 10 the the DT cord-023134-y665agnh 496 11 HSDM HSDM NNP cord-023134-y665agnh 496 12 group group NN cord-023134-y665agnh 496 13 , , , cord-023134-y665agnh 496 14 versus versus IN cord-023134-y665agnh 496 15 4.9 4.9 CD cord-023134-y665agnh 496 16 ( ( -LRB- cord-023134-y665agnh 496 17 range range NN cord-023134-y665agnh 496 18 : : : cord-023134-y665agnh 496 19 < < XX cord-023134-y665agnh 496 20 2.7 2.7 CD cord-023134-y665agnh 496 21 - - HYPH cord-023134-y665agnh 496 22 8.0 8.0 CD cord-023134-y665agnh 496 23 ) ) -RRB- cord-023134-y665agnh 496 24 in in IN cord-023134-y665agnh 496 25 the the DT cord-023134-y665agnh 496 26 DM DM NNP cord-023134-y665agnh 496 27 group group NN cord-023134-y665agnh 496 28 ( ( -LRB- cord-023134-y665agnh 496 29 p<0.001 p<0.001 CD cord-023134-y665agnh 496 30 ) ) -RRB- cord-023134-y665agnh 496 31 . . . cord-023134-y665agnh 497 1 There there EX cord-023134-y665agnh 497 2 was be VBD cord-023134-y665agnh 497 3 a a DT cord-023134-y665agnh 497 4 significant significant JJ cord-023134-y665agnh 497 5 correlation correlation NN cord-023134-y665agnh 497 6 between between IN cord-023134-y665agnh 497 7 serum serum NN cord-023134-y665agnh 497 8 IGF-1 IGF-1 NNP cord-023134-y665agnh 497 9 and and CC cord-023134-y665agnh 497 10 PIIIP PIIIP NNP cord-023134-y665agnh 497 11 ( ( -LRB- cord-023134-y665agnh 497 12 rho=0.60 rho=0.60 NNP cord-023134-y665agnh 497 13 , , , cord-023134-y665agnh 497 14 p<0.001).In p<0.001).in JJ cord-023134-y665agnh 497 15 conclusion conclusion NN cord-023134-y665agnh 497 16 , , , cord-023134-y665agnh 497 17 serum serum NN cord-023134-y665agnh 497 18 PIIIP PIIIP NNP cord-023134-y665agnh 497 19 can can MD cord-023134-y665agnh 497 20 be be VB cord-023134-y665agnh 497 21 measured measure VBN cord-023134-y665agnh 497 22 in in IN cord-023134-y665agnh 497 23 the the DT cord-023134-y665agnh 497 24 cat cat NN cord-023134-y665agnh 497 25 . . . cord-023134-y665agnh 498 1 Additionally additionally RB cord-023134-y665agnh 498 2 , , , cord-023134-y665agnh 498 3 serum serum NN cord-023134-y665agnh 498 4 PIIIP PIIIP NNP cord-023134-y665agnh 498 5 seems seem VBZ cord-023134-y665agnh 498 6 an an DT cord-023134-y665agnh 498 7 alternative alternative JJ cord-023134-y665agnh 498 8 measure measure NN cord-023134-y665agnh 498 9 of of IN cord-023134-y665agnh 498 10 growth growth NN cord-023134-y665agnh 498 11 hormone hormone NN cord-023134-y665agnh 498 12 bioactivity bioactivity NN cord-023134-y665agnh 498 13 in in IN cord-023134-y665agnh 498 14 cats cat NNS cord-023134-y665agnh 498 15 , , , cord-023134-y665agnh 498 16 given give VBN cord-023134-y665agnh 498 17 the the DT cord-023134-y665agnh 498 18 significant significant JJ cord-023134-y665agnh 498 19 elevation elevation NN cord-023134-y665agnh 498 20 in in IN cord-023134-y665agnh 498 21 concentration concentration NN cord-023134-y665agnh 498 22 in in IN cord-023134-y665agnh 498 23 feline feline JJ cord-023134-y665agnh 498 24 HS hs NN cord-023134-y665agnh 498 25 . . . cord-023134-y665agnh 499 1 Further further JJ cord-023134-y665agnh 499 2 evaluation evaluation NN cord-023134-y665agnh 499 3 of of IN cord-023134-y665agnh 499 4 PIIIP PIIIP NNP cord-023134-y665agnh 499 5 in in IN cord-023134-y665agnh 499 6 cases case NNS cord-023134-y665agnh 499 7 with with IN cord-023134-y665agnh 499 8 HS HS NNP cord-023134-y665agnh 499 9 will will MD cord-023134-y665agnh 499 10 help help VB cord-023134-y665agnh 499 11 determine determine VB cord-023134-y665agnh 499 12 the the DT cord-023134-y665agnh 499 13 exact exact JJ cord-023134-y665agnh 499 14 added add VBN cord-023134-y665agnh 499 15 value value NN cord-023134-y665agnh 499 16 of of IN cord-023134-y665agnh 499 17 evaluating evaluate VBG cord-023134-y665agnh 499 18 this this DT cord-023134-y665agnh 499 19 parameter parameter NN cord-023134-y665agnh 499 20 in in IN cord-023134-y665agnh 499 21 the the DT cord-023134-y665agnh 499 22 diagnosis diagnosis NN cord-023134-y665agnh 499 23 of of IN cord-023134-y665agnh 499 24 HS HS NNP cord-023134-y665agnh 499 25 , , , cord-023134-y665agnh 499 26 as as RB cord-023134-y665agnh 499 27 well well RB cord-023134-y665agnh 499 28 as as IN cord-023134-y665agnh 499 29 in in IN cord-023134-y665agnh 499 30 the the DT cord-023134-y665agnh 499 31 assessment assessment NN cord-023134-y665agnh 499 32 of of IN cord-023134-y665agnh 499 33 treatment treatment NN cord-023134-y665agnh 499 34 efficacy efficacy NN cord-023134-y665agnh 499 35 . . . cord-023134-y665agnh 500 1 Glucose glucose NN cord-023134-y665agnh 500 2 and and CC cord-023134-y665agnh 500 3 galactose galactose NN cord-023134-y665agnh 500 4 are be VBP cord-023134-y665agnh 500 5 transported transport VBN cord-023134-y665agnh 500 6 across across IN cord-023134-y665agnh 500 7 the the DT cord-023134-y665agnh 500 8 brush brush NN cord-023134-y665agnh 500 9 border border NN cord-023134-y665agnh 500 10 membrane membrane NN cord-023134-y665agnh 500 11 ( ( -LRB- cord-023134-y665agnh 500 12 BBM BBM NNP cord-023134-y665agnh 500 13 ) ) -RRB- cord-023134-y665agnh 500 14 of of IN cord-023134-y665agnh 500 15 enterocytes enterocyte NNS cord-023134-y665agnh 500 16 by by IN cord-023134-y665agnh 500 17 sodium sodium NN cord-023134-y665agnh 500 18 / / SYM cord-023134-y665agnh 500 19 glucose glucose NN cord-023134-y665agnh 500 20 cotransporter-1 cotransporter-1 NNP cord-023134-y665agnh 500 21 ( ( -LRB- cord-023134-y665agnh 500 22 SGLT1 SGLT1 NNP cord-023134-y665agnh 500 23 ) ) -RRB- cord-023134-y665agnh 500 24 , , , cord-023134-y665agnh 500 25 coded code VBN cord-023134-y665agnh 500 26 for for IN cord-023134-y665agnh 500 27 by by IN cord-023134-y665agnh 500 28 SLC5A1 SLC5A1 NNP cord-023134-y665agnh 500 29 . . . cord-023134-y665agnh 501 1 SGLT1is SGLT1is NNP cord-023134-y665agnh 501 2 the the DT cord-023134-y665agnh 501 3 sole sole JJ cord-023134-y665agnh 501 4 route route NN cord-023134-y665agnh 501 5 for for IN cord-023134-y665agnh 501 6 intestinal intestinal JJ cord-023134-y665agnh 501 7 glucose glucose NN cord-023134-y665agnh 501 8 absorption absorption NN cord-023134-y665agnh 501 9 and and CC cord-023134-y665agnh 501 10 its -PRON- PRP$ cord-023134-y665agnh 501 11 level level NN cord-023134-y665agnh 501 12 of of IN cord-023134-y665agnh 501 13 expression expression NN cord-023134-y665agnh 501 14 dictates dictate VBZ cord-023134-y665agnh 501 15 BBM BBM NNP cord-023134-y665agnh 501 16 transport transport NN cord-023134-y665agnh 501 17 capacity capacity NN cord-023134-y665agnh 501 18 for for IN cord-023134-y665agnh 501 19 glucose glucose NN cord-023134-y665agnh 501 20 . . . cord-023134-y665agnh 502 1 The the DT cord-023134-y665agnh 502 2 relevance relevance NN cord-023134-y665agnh 502 3 of of IN cord-023134-y665agnh 502 4 SGLT1 sglt1 NN cord-023134-y665agnh 502 5 expression expression NN cord-023134-y665agnh 502 6 in in IN cord-023134-y665agnh 502 7 predisposition predisposition NN cord-023134-y665agnh 502 8 to to IN cord-023134-y665agnh 502 9 diabetes diabetes NN cord-023134-y665agnh 502 10 mellitus mellitus NN cord-023134-y665agnh 502 11 and and CC cord-023134-y665agnh 502 12 obesity obesity NN cord-023134-y665agnh 502 13 was be VBD cord-023134-y665agnh 502 14 investigated investigate VBN cord-023134-y665agnh 502 15 in in IN cord-023134-y665agnh 502 16 dogs dog NNS cord-023134-y665agnh 502 17 . . . cord-023134-y665agnh 503 1 The the DT cord-023134-y665agnh 503 2 aims aim NNS cord-023134-y665agnh 503 3 were be VBD cord-023134-y665agnh 503 4 to to TO cord-023134-y665agnh 503 5 assess assess VB cord-023134-y665agnh 503 6 the the DT cord-023134-y665agnh 503 7 effect effect NN cord-023134-y665agnh 503 8 on on IN cord-023134-y665agnh 503 9 promoter promoter NN cord-023134-y665agnh 503 10 function function NN cord-023134-y665agnh 503 11 of of IN cord-023134-y665agnh 503 12 known know VBN cord-023134-y665agnh 503 13 SNPs snp NNS cord-023134-y665agnh 503 14 in in IN cord-023134-y665agnh 503 15 the the DT cord-023134-y665agnh 503 16 5 5 CD cord-023134-y665agnh 503 17 ' ' POS cord-023134-y665agnh 503 18 flanking flank VBG cord-023134-y665agnh 503 19 region region NN cord-023134-y665agnh 503 20 of of IN cord-023134-y665agnh 503 21 canine canine JJ cord-023134-y665agnh 503 22 SLC5A1 SLC5A1 NNP cord-023134-y665agnh 503 23 , , , cord-023134-y665agnh 503 24 and and CC cord-023134-y665agnh 503 25 to to TO cord-023134-y665agnh 503 26 search search VB cord-023134-y665agnh 503 27 for for IN cord-023134-y665agnh 503 28 novel novel JJ cord-023134-y665agnh 503 29 SNPs snp NNS cord-023134-y665agnh 503 30 in in IN cord-023134-y665agnh 503 31 well well RB cord-023134-y665agnh 503 32 defined define VBN cord-023134-y665agnh 503 33 samples sample NNS cord-023134-y665agnh 503 34 of of IN cord-023134-y665agnh 503 35 dogs dog NNS cord-023134-y665agnh 503 36 with with IN cord-023134-y665agnh 503 37 varying vary VBG cord-023134-y665agnh 503 38 risk risk NN cord-023134-y665agnh 503 39 for for IN cord-023134-y665agnh 503 40 diabetes diabetes NN cord-023134-y665agnh 503 41 or or CC cord-023134-y665agnh 503 42 obesity obesity NN cord-023134-y665agnh 503 43 . . . cord-023134-y665agnh 504 1 Caco-2 Caco-2 NNP cord-023134-y665agnh 504 2 / / SYM cord-023134-y665agnh 504 3 TC7 tc7 NN cord-023134-y665agnh 504 4 cells cell NNS cord-023134-y665agnh 504 5 were be VBD cord-023134-y665agnh 504 6 shown show VBN cord-023134-y665agnh 504 7 to to TO cord-023134-y665agnh 504 8 express express VB cord-023134-y665agnh 504 9 SGLT1 sglt1 NN cord-023134-y665agnh 504 10 in in IN cord-023134-y665agnh 504 11 vitro vitro FW cord-023134-y665agnh 504 12 . . . cord-023134-y665agnh 505 1 The the DT cord-023134-y665agnh 505 2 2kbp 2kbp CD cord-023134-y665agnh 505 3 fragment fragment NN cord-023134-y665agnh 505 4 of of IN cord-023134-y665agnh 505 5 canine canine JJ cord-023134-y665agnh 505 6 SLC5A1 SLC5A1 NNP cord-023134-y665agnh 505 7 5 5 CD cord-023134-y665agnh 505 8 ' ' POS cord-023134-y665agnh 505 9 flanking flank VBG cord-023134-y665agnh 505 10 region region NN cord-023134-y665agnh 505 11 from from IN cord-023134-y665agnh 505 12 -1974 -1974 CD cord-023134-y665agnh 505 13 to to IN cord-023134-y665agnh 505 14 +25 +25 NNP cord-023134-y665agnh 505 15 relative relative NN cord-023134-y665agnh 505 16 to to IN cord-023134-y665agnh 505 17 the the DT cord-023134-y665agnh 505 18 transcription transcription NN cord-023134-y665agnh 505 19 start start NN cord-023134-y665agnh 505 20 site site NN cord-023134-y665agnh 505 21 was be VBD cord-023134-y665agnh 505 22 cloned clone VBN cord-023134-y665agnh 505 23 from from IN cord-023134-y665agnh 505 24 canine canine JJ cord-023134-y665agnh 505 25 genomic genomic JJ cord-023134-y665agnh 505 26 DNA dna NN cord-023134-y665agnh 505 27 , , , cord-023134-y665agnh 505 28 ligated ligate VBN cord-023134-y665agnh 505 29 into into IN cord-023134-y665agnh 505 30 PGL3 PGL3 NNP cord-023134-y665agnh 505 31 basic basic JJ cord-023134-y665agnh 505 32 plasmids plasmid NNS cord-023134-y665agnh 505 33 bearing bear VBG cord-023134-y665agnh 505 34 firefly firefly NN cord-023134-y665agnh 505 35 luciferase luciferase FW cord-023134-y665agnh 505 36 as as IN cord-023134-y665agnh 505 37 a a DT cord-023134-y665agnh 505 38 reporter reporter NN cord-023134-y665agnh 505 39 gene gene NN cord-023134-y665agnh 505 40 , , , cord-023134-y665agnh 505 41 used use VBN cord-023134-y665agnh 505 42 for for IN cord-023134-y665agnh 505 43 transient transient JJ cord-023134-y665agnh 505 44 transfection transfection NN cord-023134-y665agnh 505 45 of of IN cord-023134-y665agnh 505 46 Caco-2 Caco-2 NNP cord-023134-y665agnh 505 47 / / SYM cord-023134-y665agnh 505 48 TC7 TC7 NNP cord-023134-y665agnh 505 49 cells cell NNS cord-023134-y665agnh 505 50 , , , cord-023134-y665agnh 505 51 and and CC cord-023134-y665agnh 505 52 shown show VBN cord-023134-y665agnh 505 53 to to TO cord-023134-y665agnh 505 54 drive drive VB cord-023134-y665agnh 505 55 luciferase luciferase JJ cord-023134-y665agnh 505 56 production production NN cord-023134-y665agnh 505 57 significantly significantly RB cord-023134-y665agnh 505 58 above above IN cord-023134-y665agnh 505 59 control control NN cord-023134-y665agnh 505 60 ( ( -LRB- cord-023134-y665agnh 505 61 P<0.001 P<0.001 NNP cord-023134-y665agnh 505 62 ) ) -RRB- cord-023134-y665agnh 505 63 . . . cord-023134-y665agnh 506 1 To to TO cord-023134-y665agnh 506 2 determine determine VB cord-023134-y665agnh 506 3 the the DT cord-023134-y665agnh 506 4 effect effect NN cord-023134-y665agnh 506 5 of of IN cord-023134-y665agnh 506 6 the the DT cord-023134-y665agnh 506 7 three three CD cord-023134-y665agnh 506 8 known know VBN cord-023134-y665agnh 506 9 SNPs snp NNS cord-023134-y665agnh 506 10 in in IN cord-023134-y665agnh 506 11 this this DT cord-023134-y665agnh 506 12 region region NN cord-023134-y665agnh 506 13 on on IN cord-023134-y665agnh 506 14 promoter promoter NN cord-023134-y665agnh 506 15 function function NN cord-023134-y665agnh 506 16 , , , cord-023134-y665agnh 506 17 new new JJ cord-023134-y665agnh 506 18 promoter promoter NN cord-023134-y665agnh 506 19 / / SYM cord-023134-y665agnh 506 20 reporter reporter NN cord-023134-y665agnh 506 21 constructs construct NNS cord-023134-y665agnh 506 22 ( ( -LRB- cord-023134-y665agnh 506 23 all all DT cord-023134-y665agnh 506 24 possible possible JJ cord-023134-y665agnh 506 25 permutations permutation NNS cord-023134-y665agnh 506 26 of of IN cord-023134-y665agnh 506 27 these these DT cord-023134-y665agnh 506 28 three three CD cord-023134-y665agnh 506 29 SNPs SNPs NNPS cord-023134-y665agnh 506 30 ) ) -RRB- cord-023134-y665agnh 506 31 were be VBD cord-023134-y665agnh 506 32 created create VBN cord-023134-y665agnh 506 33 using use VBG cord-023134-y665agnh 506 34 site site NN cord-023134-y665agnh 506 35 - - HYPH cord-023134-y665agnh 506 36 directed direct VBN cord-023134-y665agnh 506 37 mutagenesis mutagenesis NN cord-023134-y665agnh 506 38 . . . cord-023134-y665agnh 507 1 These these DT cord-023134-y665agnh 507 2 constructs construct NNS cord-023134-y665agnh 507 3 were be VBD cord-023134-y665agnh 507 4 used use VBN cord-023134-y665agnh 507 5 for for IN cord-023134-y665agnh 507 6 transient transient JJ cord-023134-y665agnh 507 7 transfection transfection NN cord-023134-y665agnh 507 8 of of IN cord-023134-y665agnh 507 9 Caco-2 Caco-2 NNP cord-023134-y665agnh 507 10 / / SYM cord-023134-y665agnh 507 11 TC7 tc7 NN cord-023134-y665agnh 507 12 cells cell NNS cord-023134-y665agnh 507 13 using use VBG cord-023134-y665agnh 507 14 Renilla Renilla NNP cord-023134-y665agnh 507 15 luciferase luciferase NNP cord-023134-y665agnh 507 16 as as IN cord-023134-y665agnh 507 17 an an DT cord-023134-y665agnh 507 18 internal internal JJ cord-023134-y665agnh 507 19 control control NN cord-023134-y665agnh 507 20 . . . cord-023134-y665agnh 508 1 No no DT cord-023134-y665agnh 508 2 significant significant JJ cord-023134-y665agnh 508 3 differences difference NNS cord-023134-y665agnh 508 4 in in IN cord-023134-y665agnh 508 5 promoter promoter NN cord-023134-y665agnh 508 6 function function NN cord-023134-y665agnh 508 7 were be VBD cord-023134-y665agnh 508 8 seen see VBN cord-023134-y665agnh 508 9 , , , cord-023134-y665agnh 508 10 suggesting suggest VBG cord-023134-y665agnh 508 11 that that IN cord-023134-y665agnh 508 12 these these DT cord-023134-y665agnh 508 13 three three CD cord-023134-y665agnh 508 14 SNPs SNPs NNPS cord-023134-y665agnh 508 15 do do VBP cord-023134-y665agnh 508 16 not not RB cord-023134-y665agnh 508 17 have have VB cord-023134-y665agnh 508 18 a a DT cord-023134-y665agnh 508 19 significant significant JJ cord-023134-y665agnh 508 20 effect effect NN cord-023134-y665agnh 508 21 on on IN cord-023134-y665agnh 508 22 the the DT cord-023134-y665agnh 508 23 constitutive constitutive JJ cord-023134-y665agnh 508 24 transcription transcription NN cord-023134-y665agnh 508 25 of of IN cord-023134-y665agnh 508 26 SGLT1 sglt1 NN cord-023134-y665agnh 508 27 mRNA mrna NN cord-023134-y665agnh 508 28 in in IN cord-023134-y665agnh 508 29 dogs dog NNS cord-023134-y665agnh 508 30 . . . cord-023134-y665agnh 509 1 A a DT cord-023134-y665agnh 509 2 search search NN cord-023134-y665agnh 509 3 for for IN cord-023134-y665agnh 509 4 novel novel JJ cord-023134-y665agnh 509 5 SNPs snp NNS cord-023134-y665agnh 509 6 in in IN cord-023134-y665agnh 509 7 this this DT cord-023134-y665agnh 509 8 region region NN cord-023134-y665agnh 509 9 in in IN cord-023134-y665agnh 509 10 dogs dog NNS cord-023134-y665agnh 509 11 was be VBD cord-023134-y665agnh 509 12 made make VBN cord-023134-y665agnh 509 13 in in IN cord-023134-y665agnh 509 14 two two CD cord-023134-y665agnh 509 15 breeds breed NNS cord-023134-y665agnh 509 16 predisposed predispose VBN cord-023134-y665agnh 509 17 to to IN cord-023134-y665agnh 509 18 diabetes diabetes NN cord-023134-y665agnh 509 19 mellitus mellitus NN cord-023134-y665agnh 509 20 ( ( -LRB- cord-023134-y665agnh 509 21 Samoyed Samoyed NNP cord-023134-y665agnh 509 22 , , , cord-023134-y665agnh 509 23 Cairn Cairn NNP cord-023134-y665agnh 509 24 Terrier Terrier NNP cord-023134-y665agnh 509 25 ) ) -RRB- cord-023134-y665agnh 509 26 , , , cord-023134-y665agnh 509 27 two two CD cord-023134-y665agnh 509 28 breeds breed NNS cord-023134-y665agnh 509 29 that that WDT cord-023134-y665agnh 509 30 rarely rarely RB cord-023134-y665agnh 509 31 develop develop VBP cord-023134-y665agnh 509 32 diabetes diabete NNS cord-023134-y665agnh 509 33 ( ( -LRB- cord-023134-y665agnh 509 34 Boxer Boxer NNP cord-023134-y665agnh 509 35 , , , cord-023134-y665agnh 509 36 German german JJ cord-023134-y665agnh 509 37 Shepherd Shepherd NNP cord-023134-y665agnh 509 38 Dog Dog NNP cord-023134-y665agnh 509 39 ) ) -RRB- cord-023134-y665agnh 509 40 , , , cord-023134-y665agnh 509 41 and and CC cord-023134-y665agnh 509 42 two two CD cord-023134-y665agnh 509 43 breeds breed NNS cord-023134-y665agnh 509 44 predisposed predisposed JJ cord-023134-y665agnh 509 45 to to IN cord-023134-y665agnh 509 46 obesity obesity NN cord-023134-y665agnh 509 47 ( ( -LRB- cord-023134-y665agnh 509 48 Labrador Labrador NNP cord-023134-y665agnh 509 49 Retriever Retriever NNP cord-023134-y665agnh 509 50 , , , cord-023134-y665agnh 509 51 Cocker Cocker NNP cord-023134-y665agnh 509 52 Spaniel Spaniel NNP cord-023134-y665agnh 509 53 ) ) -RRB- cord-023134-y665agnh 509 54 . . . cord-023134-y665agnh 510 1 Genomic genomic JJ cord-023134-y665agnh 510 2 DNA dna NN cord-023134-y665agnh 510 3 from from IN cord-023134-y665agnh 510 4 10 10 CD cord-023134-y665agnh 510 5 healthy healthy JJ cord-023134-y665agnh 510 6 individuals individual NNS cord-023134-y665agnh 510 7 of of IN cord-023134-y665agnh 510 8 each each DT cord-023134-y665agnh 510 9 of of IN cord-023134-y665agnh 510 10 these these DT cord-023134-y665agnh 510 11 breeds breed NNS cord-023134-y665agnh 510 12 was be VBD cord-023134-y665agnh 510 13 obtained obtain VBN cord-023134-y665agnh 510 14 from from IN cord-023134-y665agnh 510 15 the the DT cord-023134-y665agnh 510 16 UK UK NNP cord-023134-y665agnh 510 17 Companion Companion NNP cord-023134-y665agnh 510 18 Animals Animals NNPS cord-023134-y665agnh 510 19 DNA DNA NNP cord-023134-y665agnh 510 20 Archive Archive NNP cord-023134-y665agnh 510 21 , , , cord-023134-y665agnh 510 22 with with IN cord-023134-y665agnh 510 23 kind kind JJ cord-023134-y665agnh 510 24 permission permission NN cord-023134-y665agnh 510 25 . . . cord-023134-y665agnh 511 1 The the DT cord-023134-y665agnh 511 2 SLC5A1 SLC5A1 NNP cord-023134-y665agnh 511 3 5 5 CD cord-023134-y665agnh 511 4 ' ' POS cord-023134-y665agnh 511 5 flanking flank VBG cord-023134-y665agnh 511 6 region region NN cord-023134-y665agnh 511 7 was be VBD cord-023134-y665agnh 511 8 amplified amplify VBN cord-023134-y665agnh 511 9 from from IN cord-023134-y665agnh 511 10 each each DT cord-023134-y665agnh 511 11 individual individual NN cord-023134-y665agnh 511 12 by by IN cord-023134-y665agnh 511 13 high high JJ cord-023134-y665agnh 511 14 - - HYPH cord-023134-y665agnh 511 15 fidelity fidelity NN cord-023134-y665agnh 511 16 PCR pcr NN cord-023134-y665agnh 511 17 using use VBG cord-023134-y665agnh 511 18 breed breed VB cord-023134-y665agnh 511 19 - - HYPH cord-023134-y665agnh 511 20 labelled label VBN cord-023134-y665agnh 511 21 primers primer NNS cord-023134-y665agnh 511 22 , , , cord-023134-y665agnh 511 23 gel gel NN cord-023134-y665agnh 511 24 purified purify VBN cord-023134-y665agnh 511 25 , , , cord-023134-y665agnh 511 26 mixed mix VBN cord-023134-y665agnh 511 27 in in IN cord-023134-y665agnh 511 28 equimolar equimolar JJ cord-023134-y665agnh 511 29 amounts amount NNS cord-023134-y665agnh 511 30 and and CC cord-023134-y665agnh 511 31 sequenced sequence VBN cord-023134-y665agnh 511 32 by by IN cord-023134-y665agnh 511 33 pyrosequencing pyrosequence VBG cord-023134-y665agnh 511 34 ( ( -LRB- cord-023134-y665agnh 511 35 454 454 CD cord-023134-y665agnh 511 36 sequencing sequencing NN cord-023134-y665agnh 511 37 , , , cord-023134-y665agnh 511 38 GS GS NNP cord-023134-y665agnh 511 39 FLX FLX NNP cord-023134-y665agnh 511 40 , , , cord-023134-y665agnh 511 41 Roche Roche NNP cord-023134-y665agnh 511 42 ) ) -RRB- cord-023134-y665agnh 511 43 . . . cord-023134-y665agnh 512 1 The the DT cord-023134-y665agnh 512 2 sequence sequence NN cord-023134-y665agnh 512 3 of of IN cord-023134-y665agnh 512 4 the the DT cord-023134-y665agnh 512 5 SLC5A1 SLC5A1 NNP cord-023134-y665agnh 512 6 5 5 CD cord-023134-y665agnh 512 7 ' ' POS cord-023134-y665agnh 512 8 flanking flank VBG cord-023134-y665agnh 512 9 region region NN cord-023134-y665agnh 512 10 in in IN cord-023134-y665agnh 512 11 all all DT cord-023134-y665agnh 512 12 individuals individual NNS cord-023134-y665agnh 512 13 of of IN cord-023134-y665agnh 512 14 all all DT cord-023134-y665agnh 512 15 breeds breed NNS cord-023134-y665agnh 512 16 tested test VBN cord-023134-y665agnh 512 17 was be VBD cord-023134-y665agnh 512 18 identical identical JJ cord-023134-y665agnh 512 19 . . . cord-023134-y665agnh 513 1 On on IN cord-023134-y665agnh 513 2 this this DT cord-023134-y665agnh 513 3 evidence evidence NN cord-023134-y665agnh 513 4 , , , cord-023134-y665agnh 513 5 variations variation NNS cord-023134-y665agnh 513 6 in in IN cord-023134-y665agnh 513 7 SLC5A1 SLC5A1 NNP cord-023134-y665agnh 513 8 promoter promoter NN cord-023134-y665agnh 513 9 sequence sequence NN cord-023134-y665agnh 513 10 between between IN cord-023134-y665agnh 513 11 dogs dog NNS cord-023134-y665agnh 513 12 do do VBP cord-023134-y665agnh 513 13 not not RB cord-023134-y665agnh 513 14 influence influence VB cord-023134-y665agnh 513 15 the the DT cord-023134-y665agnh 513 16 pathogenesis pathogenesis NN cord-023134-y665agnh 513 17 of of IN cord-023134-y665agnh 513 18 diabetes diabetes NN cord-023134-y665agnh 513 19 or or CC cord-023134-y665agnh 513 20 obesity obesity NN cord-023134-y665agnh 513 21 in in IN cord-023134-y665agnh 513 22 these these DT cord-023134-y665agnh 513 23 breeds breed NNS cord-023134-y665agnh 513 24 . . . cord-023134-y665agnh 514 1 Remission remission NN cord-023134-y665agnh 514 2 of of IN cord-023134-y665agnh 514 3 diabetes diabetes NN cord-023134-y665agnh 514 4 mellitus mellitus NN cord-023134-y665agnh 514 5 may may MD cord-023134-y665agnh 514 6 be be VB cord-023134-y665agnh 514 7 achieved achieve VBN cord-023134-y665agnh 514 8 in in IN cord-023134-y665agnh 514 9 up up IN cord-023134-y665agnh 514 10 to to TO cord-023134-y665agnh 514 11 50 50 CD cord-023134-y665agnh 514 12 % % NN cord-023134-y665agnh 514 13 of of IN cord-023134-y665agnh 514 14 cats cat NNS cord-023134-y665agnh 514 15 . . . cord-023134-y665agnh 515 1 For for IN cord-023134-y665agnh 515 2 remission remission NN cord-023134-y665agnh 515 3 to to TO cord-023134-y665agnh 515 4 occur occur VB cord-023134-y665agnh 515 5 , , , cord-023134-y665agnh 515 6 recovery recovery NN cord-023134-y665agnh 515 7 of of IN cord-023134-y665agnh 515 8 b b NN cord-023134-y665agnh 515 9 - - HYPH cord-023134-y665agnh 515 10 cell cell NN cord-023134-y665agnh 515 11 function function NN cord-023134-y665agnh 515 12 and and CC cord-023134-y665agnh 515 13 possi possi NN cord-023134-y665agnh 515 14 - - HYPH cord-023134-y665agnh 515 15 bly bly NN cord-023134-y665agnh 515 16 of of IN cord-023134-y665agnh 515 17 b b NN cord-023134-y665agnh 515 18 - - HYPH cord-023134-y665agnh 515 19 cell cell NN cord-023134-y665agnh 515 20 mass mass NN cord-023134-y665agnh 515 21 is be VBZ cord-023134-y665agnh 515 22 required require VBN cord-023134-y665agnh 515 23 . . . cord-023134-y665agnh 516 1 A a DT cord-023134-y665agnh 516 2 novel novel JJ cord-023134-y665agnh 516 3 class class NN cord-023134-y665agnh 516 4 of of IN cord-023134-y665agnh 516 5 antidiabetic antidiabetic JJ cord-023134-y665agnh 516 6 drugs drug NNS cord-023134-y665agnh 516 7 that that WDT cord-023134-y665agnh 516 8 act act VBP cord-023134-y665agnh 516 9 via via IN cord-023134-y665agnh 516 10 the the DT cord-023134-y665agnh 516 11 incretin incretin NNP cord-023134-y665agnh 516 12 system system NN cord-023134-y665agnh 516 13 increase increase NN cord-023134-y665agnh 516 14 b b NN cord-023134-y665agnh 516 15 - - HYPH cord-023134-y665agnh 516 16 cell cell NN cord-023134-y665agnh 516 17 proliferation proliferation NN cord-023134-y665agnh 516 18 and and CC cord-023134-y665agnh 516 19 glucose glucose NN cord-023134-y665agnh 516 20 - - HYPH cord-023134-y665agnh 516 21 stimulated stimulate VBN cord-023134-y665agnh 516 22 insulin insulin NN cord-023134-y665agnh 516 23 secretion secretion NN cord-023134-y665agnh 516 24 in in IN cord-023134-y665agnh 516 25 rodents rodent NNS cord-023134-y665agnh 516 26 . . . cord-023134-y665agnh 517 1 Two two CD cord-023134-y665agnh 517 2 strategies strategy NNS cord-023134-y665agnh 517 3 of of IN cord-023134-y665agnh 517 4 incretin incretin NN cord-023134-y665agnh 517 5 - - HYPH cord-023134-y665agnh 517 6 based base VBN cord-023134-y665agnh 517 7 therapies therapy NNS cord-023134-y665agnh 517 8 , , , cord-023134-y665agnh 517 9 GLP-1 glp-1 JJ cord-023134-y665agnh 517 10 analogues analogue NNS cord-023134-y665agnh 517 11 ( ( -LRB- cord-023134-y665agnh 517 12 e.g. e.g. RB cord-023134-y665agnh 517 13 exenatide exenatide NN cord-023134-y665agnh 517 14 shortacting shortacting NN cord-023134-y665agnh 517 15 ( ( -LRB- cord-023134-y665agnh 517 16 ex ex NNP cord-023134-y665agnh 517 17 - - NN cord-023134-y665agnh 517 18 SA SA NNP cord-023134-y665agnh 517 19 ) ) -RRB- cord-023134-y665agnh 517 20 , , , cord-023134-y665agnh 517 21 exenatide exenatide VBP cord-023134-y665agnh 517 22 long long RB cord-023134-y665agnh 517 23 - - HYPH cord-023134-y665agnh 517 24 acting act VBG cord-023134-y665agnh 517 25 ( ( -LRB- cord-023134-y665agnh 517 26 ex ex NN cord-023134-y665agnh 517 27 - - JJ cord-023134-y665agnh 517 28 LA la JJ cord-023134-y665agnh 517 29 ) ) -RRB- cord-023134-y665agnh 517 30 ) ) -RRB- cord-023134-y665agnh 517 31 , , , cord-023134-y665agnh 517 32 and and CC cord-023134-y665agnh 517 33 DPP-4 DPP-4 NNP cord-023134-y665agnh 517 34 inhibitors inhibitor NNS cord-023134-y665agnh 517 35 ( ( -LRB- cord-023134-y665agnh 517 36 e.g. e.g. RB cord-023134-y665agnh 517 37 sitagliptin sitagliptin NNP cord-023134-y665agnh 517 38 ) ) -RRB- cord-023134-y665agnh 517 39 , , , cord-023134-y665agnh 517 40 are be VBP cord-023134-y665agnh 517 41 successfully successfully RB cord-023134-y665agnh 517 42 used use VBN cord-023134-y665agnh 517 43 in in IN cord-023134-y665agnh 517 44 human human JJ cord-023134-y665agnh 517 45 diabetics diabetic NNS cord-023134-y665agnh 517 46 . . . cord-023134-y665agnh 518 1 Knowledge knowledge NN cord-023134-y665agnh 518 2 about about IN cord-023134-y665agnh 518 3 the the DT cord-023134-y665agnh 518 4 use use NN cord-023134-y665agnh 518 5 of of IN cord-023134-y665agnh 518 6 incretins incretin NNS cord-023134-y665agnh 518 7 in in IN cord-023134-y665agnh 518 8 cats cat NNS cord-023134-y665agnh 518 9 is be VBZ cord-023134-y665agnh 518 10 scarce scarce JJ cord-023134-y665agnh 518 11 . . . cord-023134-y665agnh 519 1 It -PRON- PRP cord-023134-y665agnh 519 2 was be VBD cord-023134-y665agnh 519 3 demonstrated demonstrate VBN cord-023134-y665agnh 519 4 that that IN cord-023134-y665agnh 519 5 ex ex NN cord-023134-y665agnh 519 6 - - NN cord-023134-y665agnh 519 7 SA SA NNP cord-023134-y665agnh 519 8 and and CC cord-023134-y665agnh 519 9 a a DT cord-023134-y665agnh 519 10 DPP-4 DPP-4 NNP cord-023134-y665agnh 519 11 inhibitor inhibitor NN cord-023134-y665agnh 519 12 ( ( -LRB- cord-023134-y665agnh 519 13 NVP NVP NNP cord-023134-y665agnh 519 14 - - HYPH cord-023134-y665agnh 519 15 DPP728 DPP728 NNP cord-023134-y665agnh 519 16 ) ) -RRB- cord-023134-y665agnh 519 17 increase increase VBP cord-023134-y665agnh 519 18 insulin insulin NN cord-023134-y665agnh 519 19 secretion secretion NN cord-023134-y665agnh 519 20 after after IN cord-023134-y665agnh 519 21 intravenous intravenous JJ cord-023134-y665agnh 519 22 glucose glucose NN cord-023134-y665agnh 519 23 stimulation stimulation NN cord-023134-y665agnh 519 24 in in IN cord-023134-y665agnh 519 25 healthy healthy JJ cord-023134-y665agnh 519 26 cats cat NNS cord-023134-y665agnh 519 27 . . . cord-023134-y665agnh 520 1 The the DT cord-023134-y665agnh 520 2 effects effect NNS cord-023134-y665agnh 520 3 of of IN cord-023134-y665agnh 520 4 these these DT cord-023134-y665agnh 520 5 drugs drug NNS cord-023134-y665agnh 520 6 after after IN cord-023134-y665agnh 520 7 meal meal NN cord-023134-y665agnh 520 8 stimulation stimulation NN cord-023134-y665agnh 520 9 and and CC cord-023134-y665agnh 520 10 the the DT cord-023134-y665agnh 520 11 use use NN cord-023134-y665agnh 520 12 of of IN cord-023134-y665agnh 520 13 ex ex NNP cord-023134-y665agnh 520 14 - - NN cord-023134-y665agnh 520 15 LA LA NNP cord-023134-y665agnh 520 16 have have VBP cord-023134-y665agnh 520 17 not not RB cord-023134-y665agnh 520 18 been be VBN cord-023134-y665agnh 520 19 explored explore VBN cord-023134-y665agnh 520 20 in in IN cord-023134-y665agnh 520 21 cats cat NNS cord-023134-y665agnh 520 22 so so RB cord-023134-y665agnh 520 23 far far RB cord-023134-y665agnh 520 24 . . . cord-023134-y665agnh 521 1 The the DT cord-023134-y665agnh 521 2 aims aim NNS cord-023134-y665agnh 521 3 of of IN cord-023134-y665agnh 521 4 the the DT cord-023134-y665agnh 521 5 study study NN cord-023134-y665agnh 521 6 were be VBD cord-023134-y665agnh 521 7 to to TO cord-023134-y665agnh 521 8 test test VB cord-023134-y665agnh 521 9 whether whether IN cord-023134-y665agnh 521 10 ex ex JJ cord-023134-y665agnh 521 11 - - NN cord-023134-y665agnh 521 12 SA sa JJ cord-023134-y665agnh 521 13 ( ( -LRB- cord-023134-y665agnh 521 14 Byetta Byetta NNP cord-023134-y665agnh 521 15 ® ® NNP cord-023134-y665agnh 521 16 , , , cord-023134-y665agnh 521 17 q12h q12h CD cord-023134-y665agnh 521 18 , , , cord-023134-y665agnh 521 19 SC SC NNP cord-023134-y665agnh 521 20 ) ) -RRB- cord-023134-y665agnh 521 21 , , , cord-023134-y665agnh 521 22 ex ex NNP cord-023134-y665agnh 521 23 - - NN cord-023134-y665agnh 521 24 LA la JJ cord-023134-y665agnh 521 25 ( ( -LRB- cord-023134-y665agnh 521 26 Bydureon Bydureon NNP cord-023134-y665agnh 521 27 ® ® NNP cord-023134-y665agnh 521 28 , , , cord-023134-y665agnh 521 29 q5d q5d ADD cord-023134-y665agnh 521 30 , , , cord-023134-y665agnh 521 31 SC SC NNP cord-023134-y665agnh 521 32 ) ) -RRB- cord-023134-y665agnh 521 33 and and CC cord-023134-y665agnh 521 34 sitagliptin sitagliptin NNP cord-023134-y665agnh 521 35 ( ( -LRB- cord-023134-y665agnh 521 36 Januvia Januvia NNP cord-023134-y665agnh 521 37 ® ® NNP cord-023134-y665agnh 521 38 , , , cord-023134-y665agnh 521 39 q24h q24h NNS cord-023134-y665agnh 521 40 , , , cord-023134-y665agnh 521 41 PO PO NNP cord-023134-y665agnh 521 42 ) ) -RRB- cord-023134-y665agnh 521 43 can can MD cord-023134-y665agnh 521 44 be be VB cord-023134-y665agnh 521 45 safely safely RB cord-023134-y665agnh 521 46 used use VBN cord-023134-y665agnh 521 47 in in IN cord-023134-y665agnh 521 48 cats cat NNS cord-023134-y665agnh 521 49 , , , cord-023134-y665agnh 521 50 and and CC cord-023134-y665agnh 521 51 to to TO cord-023134-y665agnh 521 52 identify identify VB cord-023134-y665agnh 521 53 the the DT cord-023134-y665agnh 521 54 most most RBS cord-023134-y665agnh 521 55 effective effective JJ cord-023134-y665agnh 521 56 drug drug NN cord-023134-y665agnh 521 57 and and CC cord-023134-y665agnh 521 58 dose dose VB cord-023134-y665agnh 521 59 in in IN cord-023134-y665agnh 521 60 a a DT cord-023134-y665agnh 521 61 dose dose JJ cord-023134-y665agnh 521 62 - - HYPH cord-023134-y665agnh 521 63 escalation escalation NN cord-023134-y665agnh 521 64 study study NN cord-023134-y665agnh 521 65 . . . cord-023134-y665agnh 522 1 Nine nine CD cord-023134-y665agnh 522 2 healthy healthy JJ cord-023134-y665agnh 522 3 cats cat NNS cord-023134-y665agnh 522 4 were be VBD cord-023134-y665agnh 522 5 used use VBN cord-023134-y665agnh 522 6 . . . cord-023134-y665agnh 523 1 Ex Ex NNP cord-023134-y665agnh 523 2 - - NNP cord-023134-y665agnh 523 3 SA SA NNP cord-023134-y665agnh 523 4 was be VBD cord-023134-y665agnh 523 5 given give VBN cord-023134-y665agnh 523 6 to to IN cord-023134-y665agnh 523 7 3 3 CD cord-023134-y665agnh 523 8 cats cat NNS cord-023134-y665agnh 523 9 at at IN cord-023134-y665agnh 523 10 0.2 0.2 CD cord-023134-y665agnh 523 11 , , , cord-023134-y665agnh 523 12 0.5 0.5 CD cord-023134-y665agnh 523 13 , , , cord-023134-y665agnh 523 14 1 1 CD cord-023134-y665agnh 523 15 and and CC cord-023134-y665agnh 523 16 2 2 CD cord-023134-y665agnh 523 17 lg lg NNP cord-023134-y665agnh 523 18 / / SYM cord-023134-y665agnh 523 19 kg kg NN cord-023134-y665agnh 523 20 for for IN cord-023134-y665agnh 523 21 5 5 CD cord-023134-y665agnh 523 22 consecutive consecutive JJ cord-023134-y665agnh 523 23 days day NNS cord-023134-y665agnh 523 24 each each DT cord-023134-y665agnh 523 25 . . . cord-023134-y665agnh 524 1 Ex Ex NNP cord-023134-y665agnh 524 2 - - NNP cord-023134-y665agnh 524 3 LA LA NNP cord-023134-y665agnh 524 4 was be VBD cord-023134-y665agnh 524 5 given give VBN cord-023134-y665agnh 524 6 to to IN cord-023134-y665agnh 524 7 3 3 CD cord-023134-y665agnh 524 8 other other JJ cord-023134-y665agnh 524 9 cats cat NNS cord-023134-y665agnh 524 10 at at IN cord-023134-y665agnh 524 11 40 40 CD cord-023134-y665agnh 524 12 , , , cord-023134-y665agnh 524 13 100 100 CD cord-023134-y665agnh 524 14 , , , cord-023134-y665agnh 524 15 200 200 CD cord-023134-y665agnh 524 16 and and CC cord-023134-y665agnh 524 17 400 400 CD cord-023134-y665agnh 524 18 lg/ lg/ NNS cord-023134-y665agnh 524 19 kg kg NNS cord-023134-y665agnh 524 20 with with IN cord-023134-y665agnh 524 21 single single JJ cord-023134-y665agnh 524 22 injections injection NNS cord-023134-y665agnh 524 23 each each DT cord-023134-y665agnh 524 24 . . . cord-023134-y665agnh 525 1 Sitagliptin Sitagliptin NNP cord-023134-y665agnh 525 2 was be VBD cord-023134-y665agnh 525 3 given give VBN cord-023134-y665agnh 525 4 to to IN cord-023134-y665agnh 525 5 3 3 CD cord-023134-y665agnh 525 6 cats cat NNS cord-023134-y665agnh 525 7 at at IN cord-023134-y665agnh 525 8 1 1 CD cord-023134-y665agnh 525 9 , , , cord-023134-y665agnh 525 10 3 3 CD cord-023134-y665agnh 525 11 , , , cord-023134-y665agnh 525 12 5 5 CD cord-023134-y665agnh 525 13 and and CC cord-023134-y665agnh 525 14 10 10 CD cord-023134-y665agnh 525 15 mg mg NNS cord-023134-y665agnh 525 16 / / SYM cord-023134-y665agnh 525 17 kg kg NN cord-023134-y665agnh 525 18 for for IN cord-023134-y665agnh 525 19 5 5 CD cord-023134-y665agnh 525 20 consecutive consecutive JJ cord-023134-y665agnh 525 21 days day NNS cord-023134-y665agnh 525 22 each each DT cord-023134-y665agnh 525 23 . . . cord-023134-y665agnh 526 1 A a DT cord-023134-y665agnh 526 2 washout washout NN cord-023134-y665agnh 526 3 period period NN cord-023134-y665agnh 526 4 of of IN cord-023134-y665agnh 526 5 2 2 CD cord-023134-y665agnh 526 6 weeks week NNS cord-023134-y665agnh 526 7 was be VBD cord-023134-y665agnh 526 8 allowed allow VBN cord-023134-y665agnh 526 9 between between IN cord-023134-y665agnh 526 10 doses dose NNS cord-023134-y665agnh 526 11 . . . cord-023134-y665agnh 527 1 On on IN cord-023134-y665agnh 527 2 day day NN cord-023134-y665agnh 527 3 5 5 CD cord-023134-y665agnh 527 4 of of IN cord-023134-y665agnh 527 5 each each DT cord-023134-y665agnh 527 6 treatment treatment NN cord-023134-y665agnh 527 7 block block NN cord-023134-y665agnh 527 8 , , , cord-023134-y665agnh 527 9 a a DT cord-023134-y665agnh 527 10 meal meal NN cord-023134-y665agnh 527 11 response response NN cord-023134-y665agnh 527 12 test test NN cord-023134-y665agnh 527 13 ( ( -LRB- cord-023134-y665agnh 527 14 MRT MRT NNP cord-023134-y665agnh 527 15 ) ) -RRB- cord-023134-y665agnh 527 16 was be VBD cord-023134-y665agnh 527 17 performed perform VBN cord-023134-y665agnh 527 18 in in IN cord-023134-y665agnh 527 19 all all DT cord-023134-y665agnh 527 20 cats cat NNS cord-023134-y665agnh 527 21 after after IN cord-023134-y665agnh 527 22 a a DT cord-023134-y665agnh 527 23 16 16 CD cord-023134-y665agnh 527 24 h h NN cord-023134-y665agnh 527 25 fastby fastby NN cord-023134-y665agnh 527 26 feeding feed VBG cord-023134-y665agnh 527 27 50 50 CD cord-023134-y665agnh 527 28 % % NN cord-023134-y665agnh 527 29 of of IN cord-023134-y665agnh 527 30 daily daily JJ cord-023134-y665agnh 527 31 energy energy NN cord-023134-y665agnh 527 32 intake intake NN cord-023134-y665agnh 527 33 with with IN cord-023134-y665agnh 527 34 subsequent subsequent JJ cord-023134-y665agnh 527 35 blood blood NN cord-023134-y665agnh 527 36 sampling sampling NN cord-023134-y665agnh 527 37 at at IN cord-023134-y665agnh 527 38 timepoints timepoint NNS cord-023134-y665agnh 527 39 0 0 CD cord-023134-y665agnh 527 40 , , , cord-023134-y665agnh 527 41 15 15 CD cord-023134-y665agnh 527 42 , , , cord-023134-y665agnh 527 43 30 30 CD cord-023134-y665agnh 527 44 , , , cord-023134-y665agnh 527 45 60 60 CD cord-023134-y665agnh 527 46 , , , cord-023134-y665agnh 527 47 120 120 CD cord-023134-y665agnh 527 48 and and CC cord-023134-y665agnh 527 49 300 300 CD cord-023134-y665agnh 527 50 minutes minute NNS cord-023134-y665agnh 527 51 . . . cord-023134-y665agnh 528 1 Insulin insulin NN cord-023134-y665agnh 528 2 and and CC cord-023134-y665agnh 528 3 glucose glucose NN cord-023134-y665agnh 528 4 area area NN cord-023134-y665agnh 528 5 under under IN cord-023134-y665agnh 528 6 the the DT cord-023134-y665agnh 528 7 curves curve NNS cord-023134-y665agnh 528 8 ( ( -LRB- cord-023134-y665agnh 528 9 AUC AUC NNP cord-023134-y665agnh 528 10 ) ) -RRB- cord-023134-y665agnh 528 11 were be VBD cord-023134-y665agnh 528 12 calculated calculate VBN cord-023134-y665agnh 528 13 for for IN cord-023134-y665agnh 528 14 each each DT cord-023134-y665agnh 528 15 drug drug NN cord-023134-y665agnh 528 16 dose dose NN cord-023134-y665agnh 528 17 . . . cord-023134-y665agnh 529 1 Gastrointestinal gastrointestinal JJ cord-023134-y665agnh 529 2 side side NN cord-023134-y665agnh 529 3 effects effect NNS cord-023134-y665agnh 529 4 of of IN cord-023134-y665agnh 529 5 1 1 CD cord-023134-y665agnh 529 6 to to TO cord-023134-y665agnh 529 7 3 3 CD cord-023134-y665agnh 529 8 days day NNS cord-023134-y665agnh 529 9 duration duration NN cord-023134-y665agnh 529 10 were be VBD cord-023134-y665agnh 529 11 observed observe VBN cord-023134-y665agnh 529 12 in in IN cord-023134-y665agnh 529 13 2 2 CD cord-023134-y665agnh 529 14 cats cat NNS cord-023134-y665agnh 529 15 of of IN cord-023134-y665agnh 529 16 each each DT cord-023134-y665agnh 529 17 group group NN cord-023134-y665agnh 529 18 , , , cord-023134-y665agnh 529 19 irrespective irrespective RB cord-023134-y665agnh 529 20 of of IN cord-023134-y665agnh 529 21 the the DT cord-023134-y665agnh 529 22 dose dose NN cord-023134-y665agnh 529 23 . . . cord-023134-y665agnh 530 1 Well well UH cord-023134-y665agnh 530 2 - - HYPH cord-023134-y665agnh 530 3 being be VBG cord-023134-y665agnh 530 4 and and CC cord-023134-y665agnh 530 5 appetite appetite NN cord-023134-y665agnh 530 6 were be VBD cord-023134-y665agnh 530 7 otherwise otherwise RB cord-023134-y665agnh 530 8 conserved conserve VBN cord-023134-y665agnh 530 9 . . . cord-023134-y665agnh 531 1 Ex Ex NNP cord-023134-y665agnh 531 2 - - NNP cord-023134-y665agnh 531 3 SA SA NNP cord-023134-y665agnh 531 4 increased increase VBD cord-023134-y665agnh 531 5 insulin insulin NN cord-023134-y665agnh 531 6 AUC AUC NNP cord-023134-y665agnh 531 7 by by IN cord-023134-y665agnh 531 8 320 320 CD cord-023134-y665agnh 531 9 % % NN cord-023134-y665agnh 531 10 , , , cord-023134-y665agnh 531 11 364 364 CD cord-023134-y665agnh 531 12 % % NN cord-023134-y665agnh 531 13 , , , cord-023134-y665agnh 531 14 547 547 CD cord-023134-y665agnh 531 15 % % NN cord-023134-y665agnh 531 16 and and CC cord-023134-y665agnh 531 17 198 198 CD cord-023134-y665agnh 531 18 % % NN cord-023134-y665agnh 531 19 , , , cord-023134-y665agnh 531 20 respectively respectively RB cord-023134-y665agnh 531 21 , , , cord-023134-y665agnh 531 22 compared compare VBN cord-023134-y665agnh 531 23 to to IN cord-023134-y665agnh 531 24 insulin insulin NN cord-023134-y665agnh 531 25 AUC AUC NNP cord-023134-y665agnh 531 26 during during IN cord-023134-y665agnh 531 27 MRT MRT NNP cord-023134-y665agnh 531 28 without without IN cord-023134-y665agnh 531 29 drug drug NN cord-023134-y665agnh 531 30 administration administration NN cord-023134-y665agnh 531 31 . . . cord-023134-y665agnh 532 1 Ex Ex NNP cord-023134-y665agnh 532 2 - - NNP cord-023134-y665agnh 532 3 LA LA NNP cord-023134-y665agnh 532 4 and and CC cord-023134-y665agnh 532 5 sitagliptin sitagliptin NNP cord-023134-y665agnh 532 6 increased increase VBD cord-023134-y665agnh 532 7 insulin insulin NN cord-023134-y665agnh 532 8 AUC AUC NNP cord-023134-y665agnh 532 9 by by IN cord-023134-y665agnh 532 10 127 127 CD cord-023134-y665agnh 532 11 % % NN cord-023134-y665agnh 532 12 , , , cord-023134-y665agnh 532 13 169 169 CD cord-023134-y665agnh 532 14 % % NN cord-023134-y665agnh 532 15 , , , cord-023134-y665agnh 532 16 178 178 CD cord-023134-y665agnh 532 17 % % NN cord-023134-y665agnh 532 18 , , , cord-023134-y665agnh 532 19 95 95 CD cord-023134-y665agnh 532 20 % % NN cord-023134-y665agnh 532 21 and and CC cord-023134-y665agnh 532 22 43 43 CD cord-023134-y665agnh 532 23 % % NN cord-023134-y665agnh 532 24 , , , cord-023134-y665agnh 532 25 101 101 CD cord-023134-y665agnh 532 26 % % NN cord-023134-y665agnh 532 27 , , , cord-023134-y665agnh 532 28 70 70 CD cord-023134-y665agnh 532 29 % % NN cord-023134-y665agnh 532 30 , , , cord-023134-y665agnh 532 31 56 56 CD cord-023134-y665agnh 532 32 % % NN cord-023134-y665agnh 532 33 , , , cord-023134-y665agnh 532 34 respectively respectively RB cord-023134-y665agnh 532 35 . . . cord-023134-y665agnh 533 1 AUC AUC NNP cord-023134-y665agnh 533 2 for for IN cord-023134-y665agnh 533 3 glucose glucose NN cord-023134-y665agnh 533 4 was be VBD cord-023134-y665agnh 533 5 similar similar JJ cord-023134-y665agnh 533 6 in in IN cord-023134-y665agnh 533 7 all all DT cord-023134-y665agnh 533 8 cats cat NNS cord-023134-y665agnh 533 9 , , , cord-023134-y665agnh 533 10 irrespective irrespective RB cord-023134-y665agnh 533 11 of of IN cord-023134-y665agnh 533 12 the the DT cord-023134-y665agnh 533 13 drug drug NN cord-023134-y665agnh 533 14 and and CC cord-023134-y665agnh 533 15 dose dose NN cord-023134-y665agnh 533 16 . . . cord-023134-y665agnh 534 1 We -PRON- PRP cord-023134-y665agnh 534 2 conclude conclude VBP cord-023134-y665agnh 534 3 that that IN cord-023134-y665agnh 534 4 ex ex NNP cord-023134-y665agnh 534 5 - - NN cord-023134-y665agnh 534 6 SA sa NN cord-023134-y665agnh 534 7 , , , cord-023134-y665agnh 534 8 ex ex NNP cord-023134-y665agnh 534 9 - - NN cord-023134-y665agnh 534 10 LA la JJ cord-023134-y665agnh 534 11 and and CC cord-023134-y665agnh 534 12 sitagliptin sitagliptin NNP cord-023134-y665agnh 534 13 can can MD cord-023134-y665agnh 534 14 be be VB cord-023134-y665agnh 534 15 safely safely RB cord-023134-y665agnh 534 16 used use VBN cord-023134-y665agnh 534 17 in in IN cord-023134-y665agnh 534 18 healthy healthy JJ cord-023134-y665agnh 534 19 cats cat NNS cord-023134-y665agnh 534 20 and and CC cord-023134-y665agnh 534 21 that that IN cord-023134-y665agnh 534 22 ex ex JJ cord-023134-y665agnh 534 23 - - JJ cord-023134-y665agnh 534 24 SA sa NN cord-023134-y665agnh 534 25 increases increase VBZ cord-023134-y665agnh 534 26 insulin insulin NN cord-023134-y665agnh 534 27 secretion secretion NN cord-023134-y665agnh 534 28 more more RBR cord-023134-y665agnh 534 29 effectively effectively RB cord-023134-y665agnh 534 30 than than IN cord-023134-y665agnh 534 31 ex ex NNP cord-023134-y665agnh 534 32 - - JJ cord-023134-y665agnh 534 33 LA la JJ cord-023134-y665agnh 534 34 and and CC cord-023134-y665agnh 534 35 sitagliptin sitagliptin NNP cord-023134-y665agnh 534 36 . . . cord-023134-y665agnh 535 1 Insulin Insulin NNP cord-023134-y665agnh 535 2 detemir detemir NNP cord-023134-y665agnh 535 3 is be VBZ cord-023134-y665agnh 535 4 a a DT cord-023134-y665agnh 535 5 synthetic synthetic JJ cord-023134-y665agnh 535 6 long long JJ cord-023134-y665agnh 535 7 acting act VBG cord-023134-y665agnh 535 8 insulin insulin NN cord-023134-y665agnh 535 9 analogue analogue NN cord-023134-y665agnh 535 10 designed design VBN cord-023134-y665agnh 535 11 to to TO cord-023134-y665agnh 535 12 maintain maintain VB cord-023134-y665agnh 535 13 basal basal JJ cord-023134-y665agnh 535 14 levels level NNS cord-023134-y665agnh 535 15 of of IN cord-023134-y665agnh 535 16 insulin insulin NN cord-023134-y665agnh 535 17 in in IN cord-023134-y665agnh 535 18 humans human NNS cord-023134-y665agnh 535 19 with with IN cord-023134-y665agnh 535 20 diabetes diabetes NN cord-023134-y665agnh 535 21 mellitus mellitus NN cord-023134-y665agnh 535 22 ( ( -LRB- cord-023134-y665agnh 535 23 DM).Pharmacokinetic dm).pharmacokinetic JJ cord-023134-y665agnh 535 24 studies study NNS cord-023134-y665agnh 535 25 in in IN cord-023134-y665agnh 535 26 dogs dog NNS cord-023134-y665agnh 535 27 indicate indicate VBP cord-023134-y665agnh 535 28 that that IN cord-023134-y665agnh 535 29 insulin insulin NN cord-023134-y665agnh 535 30 detemir detemir NNP cord-023134-y665agnh 535 31 has have VBZ cord-023134-y665agnh 535 32 a a DT cord-023134-y665agnh 535 33 greater great JJR cord-023134-y665agnh 535 34 effect effect NN cord-023134-y665agnh 535 35 than than IN cord-023134-y665agnh 535 36 other other JJ cord-023134-y665agnh 535 37 types type NNS cord-023134-y665agnh 535 38 of of IN cord-023134-y665agnh 535 39 insulin insulin NN cord-023134-y665agnh 535 40 , , , cord-023134-y665agnh 535 41 requiring require VBG cord-023134-y665agnh 535 42 a a DT cord-023134-y665agnh 535 43 lower low JJR cord-023134-y665agnh 535 44 dose dose NN cord-023134-y665agnh 535 45 . . . cord-023134-y665agnh 536 1 The the DT cord-023134-y665agnh 536 2 objective objective NN cord-023134-y665agnh 536 3 of of IN cord-023134-y665agnh 536 4 our -PRON- PRP$ cord-023134-y665agnh 536 5 study study NN cord-023134-y665agnh 536 6 was be VBD cord-023134-y665agnh 536 7 to to TO cord-023134-y665agnh 536 8 evaluate evaluate VB cord-023134-y665agnh 536 9 its -PRON- PRP$ cord-023134-y665agnh 536 10 efficacy efficacy NN cord-023134-y665agnh 536 11 and and CC cord-023134-y665agnh 536 12 the the DT cord-023134-y665agnh 536 13 frequency frequency NN cord-023134-y665agnh 536 14 of of IN cord-023134-y665agnh 536 15 hypoglycemia hypoglycemia NN cord-023134-y665agnh 536 16 in in IN cord-023134-y665agnh 536 17 dogs dog NNS cord-023134-y665agnh 536 18 with with IN cord-023134-y665agnh 536 19 DM DM NNP cord-023134-y665agnh 536 20 treated treat VBN cord-023134-y665agnh 536 21 with with IN cord-023134-y665agnh 536 22 insulin insulin NN cord-023134-y665agnh 536 23 detemir detemir NNP cord-023134-y665agnh 536 24 . . . cord-023134-y665agnh 537 1 Eight eight CD cord-023134-y665agnh 537 2 dogs dog NNS cord-023134-y665agnh 537 3 were be VBD cord-023134-y665agnh 537 4 included include VBN cord-023134-y665agnh 537 5 into into IN cord-023134-y665agnh 537 6 the the DT cord-023134-y665agnh 537 7 study study NN cord-023134-y665agnh 537 8 . . . cord-023134-y665agnh 538 1 Median median JJ cord-023134-y665agnh 538 2 ( ( -LRB- cord-023134-y665agnh 538 3 range range NN cord-023134-y665agnh 538 4 ) ) -RRB- cord-023134-y665agnh 538 5 age age NN cord-023134-y665agnh 538 6 was be VBD cord-023134-y665agnh 538 7 9 9 CD cord-023134-y665agnh 538 8 years year NNS cord-023134-y665agnh 538 9 ( ( -LRB- cord-023134-y665agnh 538 10 7 7 CD cord-023134-y665agnh 538 11 - - SYM cord-023134-y665agnh 538 12 12 12 CD cord-023134-y665agnh 538 13 ) ) -RRB- cord-023134-y665agnh 538 14 , , , cord-023134-y665agnh 538 15 7 7 CD cord-023134-y665agnh 538 16 were be VBD cord-023134-y665agnh 538 17 female female JJ cord-023134-y665agnh 538 18 ( ( -LRB- cord-023134-y665agnh 538 19 2 2 CD cord-023134-y665agnh 538 20 intact intact JJ cord-023134-y665agnh 538 21 , , , cord-023134-y665agnh 538 22 5 5 CD cord-023134-y665agnh 538 23 spayed spayed JJ cord-023134-y665agnh 538 24 ) ) -RRB- cord-023134-y665agnh 538 25 , , , cord-023134-y665agnh 538 26 and and CC cord-023134-y665agnh 538 27 1 1 CD cord-023134-y665agnh 538 28 was be VBD cord-023134-y665agnh 538 29 intact intact JJ cord-023134-y665agnh 538 30 male male JJ cord-023134-y665agnh 538 31 ; ; , cord-023134-y665agnh 538 32 median median JJ cord-023134-y665agnh 538 33 ( ( -LRB- cord-023134-y665agnh 538 34 range range NN cord-023134-y665agnh 538 35 ) ) -RRB- cord-023134-y665agnh 538 36 body body NN cord-023134-y665agnh 538 37 weight weight NN cord-023134-y665agnh 538 38 was be VBD cord-023134-y665agnh 538 39 8.5 8.5 CD cord-023134-y665agnh 538 40 kg kg NNS cord-023134-y665agnh 538 41 ( ( -LRB- cord-023134-y665agnh 538 42 3.7 3.7 CD cord-023134-y665agnh 538 43 - - HYPH cord-023134-y665agnh 538 44 42.0 42.0 CD cord-023134-y665agnh 538 45 ) ) -RRB- cord-023134-y665agnh 538 46 . . . cord-023134-y665agnh 539 1 Dogs dog NNS cord-023134-y665agnh 539 2 with with IN cord-023134-y665agnh 539 3 relevant relevant JJ cord-023134-y665agnh 539 4 concurrent concurrent JJ cord-023134-y665agnh 539 5 diseases disease NNS cord-023134-y665agnh 539 6 ( ( -LRB- cord-023134-y665agnh 539 7 e.g. e.g. JJ cord-023134-y665agnh 539 8 hypothyroidism hypothyroidism NN cord-023134-y665agnh 539 9 , , , cord-023134-y665agnh 539 10 hypercortisolism hypercortisolism NN cord-023134-y665agnh 539 11 , , , cord-023134-y665agnh 539 12 neoplasia neoplasia NN cord-023134-y665agnh 539 13 , , , cord-023134-y665agnh 539 14 renal renal JJ cord-023134-y665agnh 539 15 insufficiency insufficiency NN cord-023134-y665agnh 539 16 ) ) -RRB- cord-023134-y665agnh 539 17 and and CC cord-023134-y665agnh 539 18 dogs dog NNS cord-023134-y665agnh 539 19 with with IN cord-023134-y665agnh 539 20 prior prior JJ cord-023134-y665agnh 539 21 administration administration NN cord-023134-y665agnh 539 22 of of IN cord-023134-y665agnh 539 23 diabetogenic diabetogenic NNP cord-023134-y665agnh 539 24 drugs drug NNS cord-023134-y665agnh 539 25 were be VBD cord-023134-y665agnh 539 26 excluded exclude VBN cord-023134-y665agnh 539 27 . . . cord-023134-y665agnh 540 1 All all DT cord-023134-y665agnh 540 2 dogs dog NNS cord-023134-y665agnh 540 3 received receive VBD cord-023134-y665agnh 540 4 insulin insulin NN cord-023134-y665agnh 540 5 detemir detemir NNP cord-023134-y665agnh 540 6 BID BID VBN cord-023134-y665agnh 540 7 for for IN cord-023134-y665agnh 540 8 at at RB cord-023134-y665agnh 540 9 least least RBS cord-023134-y665agnh 540 10 6 6 CD cord-023134-y665agnh 540 11 months month NNS cord-023134-y665agnh 540 12 , , , cord-023134-y665agnh 540 13 re re NNS cord-023134-y665agnh 540 14 - - NNS cord-023134-y665agnh 540 15 evaluations evaluation NNS cord-023134-y665agnh 540 16 were be VBD cord-023134-y665agnh 540 17 performed perform VBN cord-023134-y665agnh 540 18 after after IN cord-023134-y665agnh 540 19 1 1 CD cord-023134-y665agnh 540 20 , , , cord-023134-y665agnh 540 21 2 2 CD cord-023134-y665agnh 540 22 , , , cord-023134-y665agnh 540 23 4 4 CD cord-023134-y665agnh 540 24 , , , cord-023134-y665agnh 540 25 12 12 CD cord-023134-y665agnh 540 26 and and CC cord-023134-y665agnh 540 27 24 24 CD cord-023134-y665agnh 540 28 weeks week NNS cord-023134-y665agnh 540 29 and and CC cord-023134-y665agnh 540 30 included include VBD cord-023134-y665agnh 540 31 clinical clinical JJ cord-023134-y665agnh 540 32 signs sign NNS cord-023134-y665agnh 540 33 , , , cord-023134-y665agnh 540 34 blood blood NN cord-023134-y665agnh 540 35 glucose glucose NN cord-023134-y665agnh 540 36 curves curve NNS cord-023134-y665agnh 540 37 ( ( -LRB- cord-023134-y665agnh 540 38 BGC BGC NNP cord-023134-y665agnh 540 39 ) ) -RRB- cord-023134-y665agnh 540 40 and and CC cord-023134-y665agnh 540 41 fructosamine fructosamine NN cord-023134-y665agnh 540 42 concentrations concentration NNS cord-023134-y665agnh 540 43 . . . cord-023134-y665agnh 541 1 Median median JJ cord-023134-y665agnh 541 2 ( ( -LRB- cord-023134-y665agnh 541 3 range range NN cord-023134-y665agnh 541 4 ) ) -RRB- cord-023134-y665agnh 541 5 insulin insulin NN cord-023134-y665agnh 541 6 dose dose NN cord-023134-y665agnh 541 7 was be VBD cord-023134-y665agnh 542 1 0.12 0.12 CD cord-023134-y665agnh 542 2 U U NNP cord-023134-y665agnh 542 3 / / SYM cord-023134-y665agnh 542 4 kg kg NN cord-023134-y665agnh 542 5 ( ( -LRB- cord-023134-y665agnh 542 6 0.07 0.07 CD cord-023134-y665agnh 542 7 - - SYM cord-023134-y665agnh 542 8 0.13 0.13 CD cord-023134-y665agnh 542 9 ) ) -RRB- cord-023134-y665agnh 542 10 BID BID VBN cord-023134-y665agnh 542 11 at at IN cord-023134-y665agnh 542 12 admission admission NN cord-023134-y665agnh 542 13 which which WDT cord-023134-y665agnh 542 14 was be VBD cord-023134-y665agnh 542 15 not not RB cord-023134-y665agnh 542 16 significantly significantly RB cord-023134-y665agnh 542 17 different different JJ cord-023134-y665agnh 542 18 after after IN cord-023134-y665agnh 542 19 24 24 CD cord-023134-y665agnh 542 20 weeks week NNS cord-023134-y665agnh 542 21 of of IN cord-023134-y665agnh 542 22 therapy therapy NN cord-023134-y665agnh 542 23 ( ( -LRB- cord-023134-y665agnh 542 24 0.12 0.12 CD cord-023134-y665agnh 542 25 U U NNP cord-023134-y665agnh 542 26 / / SYM cord-023134-y665agnh 542 27 kg kg NN cord-023134-y665agnh 542 28 , , , cord-023134-y665agnh 542 29 range range VBP cord-023134-y665agnh 542 30 0.05 0.05 CD cord-023134-y665agnh 542 31 - - HYPH cord-023134-y665agnh 542 32 0.34 0.34 CD cord-023134-y665agnh 542 33 ) ) -RRB- cord-023134-y665agnh 542 34 . . . cord-023134-y665agnh 543 1 Initially initially RB cord-023134-y665agnh 543 2 , , , cord-023134-y665agnh 543 3 all all DT cord-023134-y665agnh 543 4 dogs dog NNS cord-023134-y665agnh 543 5 had have VBD cord-023134-y665agnh 543 6 markedly markedly RB cord-023134-y665agnh 543 7 elevated elevate VBN cord-023134-y665agnh 543 8 blood blood NN cord-023134-y665agnh 543 9 glucose glucose NN cord-023134-y665agnh 543 10 ( ( -LRB- cord-023134-y665agnh 543 11 21.9 21.9 CD cord-023134-y665agnh 543 12 mmol mmol NNP cord-023134-y665agnh 543 13 / / SYM cord-023134-y665agnh 543 14 l l NN cord-023134-y665agnh 543 15 , , , cord-023134-y665agnh 543 16 20.5 20.5 CD cord-023134-y665agnh 543 17 - - HYPH cord-023134-y665agnh 543 18 29.6 29.6 CD cord-023134-y665agnh 543 19 mmol mmol NNP cord-023134-y665agnh 543 20 / / SYM cord-023134-y665agnh 543 21 l l NNP cord-023134-y665agnh 543 22 ) ) -RRB- cord-023134-y665agnh 543 23 , , , cord-023134-y665agnh 543 24 and and CC cord-023134-y665agnh 543 25 elevated elevate VBN cord-023134-y665agnh 543 26 fructosamine fructosamine NN cord-023134-y665agnh 543 27 concentrations concentration NNS cord-023134-y665agnh 543 28 ( ( -LRB- cord-023134-y665agnh 543 29 547 547 CD cord-023134-y665agnh 543 30 lmol lmol NNP cord-023134-y665agnh 543 31 / / SYM cord-023134-y665agnh 543 32 l l NN cord-023134-y665agnh 543 33 , , , cord-023134-y665agnh 543 34 430 430 CD cord-023134-y665agnh 543 35 - - SYM cord-023134-y665agnh 543 36 702 702 CD cord-023134-y665agnh 543 37 lmol lmol NNP cord-023134-y665agnh 543 38 / / SYM cord-023134-y665agnh 543 39 l l NN cord-023134-y665agnh 543 40 ) ) -RRB- cord-023134-y665agnh 543 41 . . . cord-023134-y665agnh 544 1 Mean(±SD mean(±sd LS cord-023134-y665agnh 544 2 ) ) -RRB- cord-023134-y665agnh 544 3 glucose glucose NN cord-023134-y665agnh 544 4 concentrations concentration NNS cord-023134-y665agnh 544 5 ( ( -LRB- cord-023134-y665agnh 544 6 mmol mmol NNP cord-023134-y665agnh 544 7 / / SYM cord-023134-y665agnh 544 8 l l NN cord-023134-y665agnh 544 9 ) ) -RRB- cord-023134-y665agnh 544 10 of of IN cord-023134-y665agnh 544 11 the the DT cord-023134-y665agnh 544 12 BGC BGC NNP cord-023134-y665agnh 544 13 at at IN cord-023134-y665agnh 544 14 each each DT cord-023134-y665agnh 544 15 re re NN cord-023134-y665agnh 544 16 - - NN cord-023134-y665agnh 544 17 evaluation evaluation NN cord-023134-y665agnh 544 18 were be VBD cord-023134-y665agnh 544 19 12.2±5.1 12.2±5.1 CD cord-023134-y665agnh 544 20 , , , cord-023134-y665agnh 544 21 15.1±5.3 15.1±5.3 CD cord-023134-y665agnh 544 22 , , , cord-023134-y665agnh 544 23 14.0±6.9 14.0±6.9 CD cord-023134-y665agnh 544 24 , , , cord-023134-y665agnh 544 25 17.9±8.3 17.9±8.3 CD cord-023134-y665agnh 544 26 , , , cord-023134-y665agnh 544 27 14.0±3.7 14.0±3.7 CD cord-023134-y665agnh 544 28 ; ; : cord-023134-y665agnh 544 29 median median JJ cord-023134-y665agnh 544 30 ( ( -LRB- cord-023134-y665agnh 544 31 range range NN cord-023134-y665agnh 544 32 ) ) -RRB- cord-023134-y665agnh 544 33 of of IN cord-023134-y665agnh 544 34 the the DT cord-023134-y665agnh 544 35 glucose glucose NN cord-023134-y665agnh 544 36 nadir nadir NN cord-023134-y665agnh 544 37 values value NNS cord-023134-y665agnh 544 38 ( ( -LRB- cord-023134-y665agnh 544 39 mmol mmol NNP cord-023134-y665agnh 544 40 / / SYM cord-023134-y665agnh 544 41 l l NN cord-023134-y665agnh 544 42 ) ) -RRB- cord-023134-y665agnh 544 43 were be VBD cord-023134-y665agnh 544 44 9.4 9.4 CD cord-023134-y665agnh 544 45 ( ( -LRB- cord-023134-y665agnh 544 46 2.3 2.3 CD cord-023134-y665agnh 544 47 - - SYM cord-023134-y665agnh 544 48 11.9 11.9 CD cord-023134-y665agnh 544 49 ) ) -RRB- cord-023134-y665agnh 544 50 , , , cord-023134-y665agnh 544 51 10.9 10.9 CD cord-023134-y665agnh 544 52 ( ( -LRB- cord-023134-y665agnh 544 53 3.6 3.6 CD cord-023134-y665agnh 544 54 - - SYM cord-023134-y665agnh 544 55 18.1 18.1 CD cord-023134-y665agnh 544 56 ) ) -RRB- cord-023134-y665agnh 544 57 , , , cord-023134-y665agnh 544 58 6.6 6.6 CD cord-023134-y665agnh 544 59 ( ( -LRB- cord-023134-y665agnh 544 60 2.7 2.7 CD cord-023134-y665agnh 544 61 - - SYM cord-023134-y665agnh 544 62 8.0 8.0 CD cord-023134-y665agnh 544 63 ) ) -RRB- cord-023134-y665agnh 544 64 , , , cord-023134-y665agnh 544 65 10.3 10.3 CD cord-023134-y665agnh 544 66 ( ( -LRB- cord-023134-y665agnh 544 67 3.9 3.9 CD cord-023134-y665agnh 544 68 - - HYPH cord-023134-y665agnh 544 69 24.8 24.8 CD cord-023134-y665agnh 544 70 ) ) -RRB- cord-023134-y665agnh 544 71 , , , cord-023134-y665agnh 544 72 6.2 6.2 CD cord-023134-y665agnh 544 73 ( ( -LRB- cord-023134-y665agnh 544 74 3.4 3.4 CD cord-023134-y665agnh 544 75 - - SYM cord-023134-y665agnh 544 76 12.1 12.1 CD cord-023134-y665agnh 544 77 ) ) -RRB- cord-023134-y665agnh 544 78 and and CC cord-023134-y665agnh 544 79 fructosamine fructosamine NN cord-023134-y665agnh 544 80 concentrations concentration NNS cord-023134-y665agnh 544 81 ( ( -LRB- cord-023134-y665agnh 544 82 lmol lmol NNP cord-023134-y665agnh 544 83 / / SYM cord-023134-y665agnh 544 84 l l NN cord-023134-y665agnh 544 85 ) ) -RRB- cord-023134-y665agnh 545 1 were be VBD cord-023134-y665agnh 545 2 509 509 CD cord-023134-y665agnh 545 3 ( ( -LRB- cord-023134-y665agnh 545 4 274 274 CD cord-023134-y665agnh 545 5 - - SYM cord-023134-y665agnh 545 6 683 683 CD cord-023134-y665agnh 545 7 ) ) -RRB- cord-023134-y665agnh 545 8 , , . cord-023134-y665agnh 546 1 470 470 CD cord-023134-y665agnh 546 2 ( ( -LRB- cord-023134-y665agnh 546 3 314 314 CD cord-023134-y665agnh 546 4 - - SYM cord-023134-y665agnh 546 5 749 749 CD cord-023134-y665agnh 546 6 ) ) -RRB- cord-023134-y665agnh 546 7 , , , cord-023134-y665agnh 546 8 445 445 CD cord-023134-y665agnh 546 9 ( ( -LRB- cord-023134-y665agnh 546 10 379 379 CD cord-023134-y665agnh 546 11 - - SYM cord-023134-y665agnh 546 12 460 460 CD cord-023134-y665agnh 546 13 ) ) -RRB- cord-023134-y665agnh 546 14 , , . cord-023134-y665agnh 547 1 501 501 CD cord-023134-y665agnh 547 2 ( ( -LRB- cord-023134-y665agnh 547 3 417 417 CD cord-023134-y665agnh 547 4 - - SYM cord-023134-y665agnh 547 5 653 653 CD cord-023134-y665agnh 547 6 ) ) -RRB- cord-023134-y665agnh 547 7 , , , cord-023134-y665agnh 547 8 480 480 CD cord-023134-y665agnh 547 9 ( ( -LRB- cord-023134-y665agnh 547 10 382 382 CD cord-023134-y665agnh 547 11 - - SYM cord-023134-y665agnh 547 12 571 571 CD cord-023134-y665agnh 547 13 ) ) -RRB- cord-023134-y665agnh 547 14 , , , cord-023134-y665agnh 547 15 respectively respectively RB cord-023134-y665agnh 547 16 . . . cord-023134-y665agnh 548 1 Glucose glucose NN cord-023134-y665agnh 548 2 concentrations concentration NNS cord-023134-y665agnh 548 3 ( ( -LRB- cord-023134-y665agnh 548 4 mean mean VBP cord-023134-y665agnh 548 5 ) ) -RRB- cord-023134-y665agnh 548 6 were be VBD cord-023134-y665agnh 548 7 significantly significantly RB cord-023134-y665agnh 548 8 ( ( -LRB- cord-023134-y665agnh 548 9 p<0.001 p<0.001 NNS cord-023134-y665agnh 548 10 ) ) -RRB- cord-023134-y665agnh 548 11 lower low JJR cord-023134-y665agnh 548 12 after after IN cord-023134-y665agnh 548 13 24 24 CD cord-023134-y665agnh 548 14 weeks week NNS cord-023134-y665agnh 548 15 therapy therapy NN cord-023134-y665agnh 548 16 than than IN cord-023134-y665agnh 548 17 before before IN cord-023134-y665agnh 548 18 treatment treatment NN cord-023134-y665agnh 548 19 . . . cord-023134-y665agnh 549 1 Hypoglycemia hypoglycemia NN cord-023134-y665agnh 549 2 ( ( -LRB- cord-023134-y665agnh 549 3 glucose glucose NN cord-023134-y665agnh 549 4 nadir nadir NNP cord-023134-y665agnh 549 5 < < XX cord-023134-y665agnh 549 6 5 5 CD cord-023134-y665agnh 549 7 mmol mmol NNP cord-023134-y665agnh 549 8 / / SYM cord-023134-y665agnh 549 9 l l NN cord-023134-y665agnh 549 10 ) ) -RRB- cord-023134-y665agnh 549 11 was be VBD cord-023134-y665agnh 549 12 a a DT cord-023134-y665agnh 549 13 consistent consistent JJ cord-023134-y665agnh 549 14 problem problem NN cord-023134-y665agnh 549 15 , , , cord-023134-y665agnh 549 16 identified identify VBN cord-023134-y665agnh 549 17 in in IN cord-023134-y665agnh 549 18 5 5 CD cord-023134-y665agnh 549 19 dogs dog NNS cord-023134-y665agnh 549 20 ( ( -LRB- cord-023134-y665agnh 549 21 23 23 CD cord-023134-y665agnh 549 22 % % NN cord-023134-y665agnh 549 23 of of IN cord-023134-y665agnh 549 24 the the DT cord-023134-y665agnh 549 25 BGC BGC NNP cord-023134-y665agnh 549 26 of of IN cord-023134-y665agnh 549 27 the the DT cord-023134-y665agnh 549 28 8 8 CD cord-023134-y665agnh 549 29 dogs dog NNS cord-023134-y665agnh 549 30 ) ) -RRB- cord-023134-y665agnh 549 31 . . . cord-023134-y665agnh 550 1 There there EX cord-023134-y665agnh 550 2 were be VBD cord-023134-y665agnh 550 3 6 6 CD cord-023134-y665agnh 550 4 episodes episode NNS cord-023134-y665agnh 550 5 ( ( -LRB- cord-023134-y665agnh 550 6 in in IN cord-023134-y665agnh 550 7 4 4 CD cord-023134-y665agnh 550 8 dogs dog NNS cord-023134-y665agnh 550 9 ) ) -RRB- cord-023134-y665agnh 550 10 of of IN cord-023134-y665agnh 550 11 owners owner NNS cord-023134-y665agnh 550 12 reporting report VBG cord-023134-y665agnh 550 13 clinical clinical JJ cord-023134-y665agnh 550 14 signs sign NNS cord-023134-y665agnh 550 15 ( ( -LRB- cord-023134-y665agnh 550 16 lethargy lethargy NN cord-023134-y665agnh 550 17 , , , cord-023134-y665agnh 550 18 weakness weakness NN cord-023134-y665agnh 550 19 , , , cord-023134-y665agnh 550 20 unsteady unsteady JJ cord-023134-y665agnh 550 21 gait gait NN cord-023134-y665agnh 550 22 ) ) -RRB- cord-023134-y665agnh 550 23 that that WDT cord-023134-y665agnh 550 24 could could MD cord-023134-y665agnh 550 25 have have VB cord-023134-y665agnh 550 26 been be VBN cord-023134-y665agnh 550 27 caused cause VBN cord-023134-y665agnh 550 28 by by IN cord-023134-y665agnh 550 29 hypoglycemia hypoglycemia NN cord-023134-y665agnh 550 30 . . . cord-023134-y665agnh 551 1 Based base VBN cord-023134-y665agnh 551 2 on on IN cord-023134-y665agnh 551 3 owner owner NN cord-023134-y665agnh 551 4 opinion opinion NN cord-023134-y665agnh 551 5 , , , cord-023134-y665agnh 551 6 clinical clinical JJ cord-023134-y665agnh 551 7 assessment assessment NN cord-023134-y665agnh 551 8 of of IN cord-023134-y665agnh 551 9 the the DT cord-023134-y665agnh 551 10 veterinarian veterinarian NN cord-023134-y665agnh 551 11 and and CC cord-023134-y665agnh 551 12 BGC BGC NNP cord-023134-y665agnh 551 13 after after IN cord-023134-y665agnh 551 14 6 6 CD cord-023134-y665agnh 551 15 months month NNS cord-023134-y665agnh 551 16 of of IN cord-023134-y665agnh 551 17 therapy therapy NN cord-023134-y665agnh 551 18 , , , cord-023134-y665agnh 551 19 good good JJ cord-023134-y665agnh 551 20 control control NN cord-023134-y665agnh 551 21 of of IN cord-023134-y665agnh 551 22 the the DT cord-023134-y665agnh 551 23 disease disease NN cord-023134-y665agnh 551 24 was be VBD cord-023134-y665agnh 551 25 obtained obtain VBN cord-023134-y665agnh 551 26 in in IN cord-023134-y665agnh 551 27 5 5 CD cord-023134-y665agnh 551 28 ( ( -LRB- cord-023134-y665agnh 551 29 62 62 CD cord-023134-y665agnh 551 30 % % NN cord-023134-y665agnh 551 31 ) ) -RRB- cord-023134-y665agnh 551 32 and and CC cord-023134-y665agnh 551 33 moderate moderate JJ cord-023134-y665agnh 551 34 control control NN cord-023134-y665agnh 551 35 in in IN cord-023134-y665agnh 551 36 3 3 CD cord-023134-y665agnh 551 37 dogs dog NNS cord-023134-y665agnh 551 38 ( ( -LRB- cord-023134-y665agnh 551 39 38 38 CD cord-023134-y665agnh 551 40 % % NN cord-023134-y665agnh 551 41 ) ) -RRB- cord-023134-y665agnh 551 42 . . . cord-023134-y665agnh 552 1 According accord VBG cord-023134-y665agnh 552 2 to to IN cord-023134-y665agnh 552 3 our -PRON- PRP$ cord-023134-y665agnh 552 4 preliminary preliminary JJ cord-023134-y665agnh 552 5 results result NNS cord-023134-y665agnh 552 6 insulin insulin NN cord-023134-y665agnh 552 7 detemir detemir NNP cord-023134-y665agnh 552 8 is be VBZ cord-023134-y665agnh 552 9 effective effective JJ cord-023134-y665agnh 552 10 in in IN cord-023134-y665agnh 552 11 controlling control VBG cord-023134-y665agnh 552 12 hyperglycemia hyperglycemia NN cord-023134-y665agnh 552 13 in in IN cord-023134-y665agnh 552 14 dogs dog NNS cord-023134-y665agnh 552 15 with with IN cord-023134-y665agnh 552 16 DM DM NNP cord-023134-y665agnh 552 17 . . . cord-023134-y665agnh 553 1 It -PRON- PRP cord-023134-y665agnh 553 2 is be VBZ cord-023134-y665agnh 553 3 more more RBR cord-023134-y665agnh 553 4 potent potent JJ cord-023134-y665agnh 553 5 than than IN cord-023134-y665agnh 553 6 other other JJ cord-023134-y665agnh 553 7 types type NNS cord-023134-y665agnh 553 8 of of IN cord-023134-y665agnh 553 9 insulin insulin NN cord-023134-y665agnh 553 10 which which WDT cord-023134-y665agnh 553 11 are be VBP cord-023134-y665agnh 553 12 also also RB cord-023134-y665agnh 553 13 used use VBN cord-023134-y665agnh 553 14 BID bid NN cord-023134-y665agnh 553 15 and and CC cord-023134-y665agnh 553 16 therefore therefore RB cord-023134-y665agnh 553 17 lower low JJR cord-023134-y665agnh 553 18 doses dose NNS cord-023134-y665agnh 553 19 were be VBD cord-023134-y665agnh 553 20 used use VBN cord-023134-y665agnh 553 21 . . . cord-023134-y665agnh 554 1 Nevertheless nevertheless RB cord-023134-y665agnh 554 2 hypoglycemia hypoglycemia NN cord-023134-y665agnh 554 3 was be VBD cord-023134-y665agnh 554 4 a a DT cord-023134-y665agnh 554 5 common common JJ cord-023134-y665agnh 554 6 finding finding NN cord-023134-y665agnh 554 7 especially especially RB cord-023134-y665agnh 554 8 in in IN cord-023134-y665agnh 554 9 small small JJ cord-023134-y665agnh 554 10 dogs dog NNS cord-023134-y665agnh 554 11 . . . cord-023134-y665agnh 555 1 Therefore therefore RB cord-023134-y665agnh 555 2 insulin insulin NN cord-023134-y665agnh 555 3 detemir detemir NN cord-023134-y665agnh 555 4 should should MD cord-023134-y665agnh 555 5 be be VB cord-023134-y665agnh 555 6 used use VBN cord-023134-y665agnh 555 7 with with IN cord-023134-y665agnh 555 8 great great JJ cord-023134-y665agnh 555 9 caution caution NN cord-023134-y665agnh 555 10 and and CC cord-023134-y665agnh 555 11 dilution dilution NN cord-023134-y665agnh 555 12 could could MD cord-023134-y665agnh 555 13 be be VB cord-023134-y665agnh 555 14 considered consider VBN cord-023134-y665agnh 555 15 . . . cord-023134-y665agnh 556 1 Spontaneous spontaneous JJ cord-023134-y665agnh 556 2 hypercortisolism hypercortisolism NN cord-023134-y665agnh 556 3 is be VBZ cord-023134-y665agnh 556 4 due due JJ cord-023134-y665agnh 556 5 to to IN cord-023134-y665agnh 556 6 ACTH ACTH NNP cord-023134-y665agnh 556 7 - - HYPH cord-023134-y665agnh 556 8 independent independent JJ cord-023134-y665agnh 556 9 hypersecretion hypersecretion NN cord-023134-y665agnh 556 10 of of IN cord-023134-y665agnh 556 11 cortisol cortisol NN cord-023134-y665agnh 556 12 by by IN cord-023134-y665agnh 556 13 an an DT cord-023134-y665agnh 556 14 adrenocortical adrenocortical JJ cord-023134-y665agnh 556 15 tumor tumor NN cord-023134-y665agnh 557 1 ( ( -LRB- cord-023134-y665agnh 557 2 AT at IN cord-023134-y665agnh 557 3 ) ) -RRB- cord-023134-y665agnh 557 4 in in IN cord-023134-y665agnh 557 5 about about RB cord-023134-y665agnh 557 6 15 15 CD cord-023134-y665agnh 557 7 % % NN cord-023134-y665agnh 557 8 of of IN cord-023134-y665agnh 557 9 the the DT cord-023134-y665agnh 557 10 cases case NNS cord-023134-y665agnh 557 11 . . . cord-023134-y665agnh 558 1 Although although IN cord-023134-y665agnh 558 2 the the DT cord-023134-y665agnh 558 3 understanding understanding NN cord-023134-y665agnh 558 4 of of IN cord-023134-y665agnh 558 5 growth growth NN cord-023134-y665agnh 558 6 and and CC cord-023134-y665agnh 558 7 hormonal hormonal JJ cord-023134-y665agnh 558 8 activity activity NN cord-023134-y665agnh 558 9 of of IN cord-023134-y665agnh 558 10 ATs ATs NNP cord-023134-y665agnh 558 11 has have VBZ cord-023134-y665agnh 558 12 expanded expand VBN cord-023134-y665agnh 558 13 in in IN cord-023134-y665agnh 558 14 recent recent JJ cord-023134-y665agnh 558 15 years year NNS cord-023134-y665agnh 558 16 , , , cord-023134-y665agnh 558 17 the the DT cord-023134-y665agnh 558 18 pivotal pivotal JJ cord-023134-y665agnh 558 19 factors factor NNS cord-023134-y665agnh 558 20 / / SYM cord-023134-y665agnh 558 21 acts act NNS cord-023134-y665agnh 558 22 in in IN cord-023134-y665agnh 558 23 the the DT cord-023134-y665agnh 558 24 pathogenesis pathogenesis NN cord-023134-y665agnh 558 25 of of IN cord-023134-y665agnh 558 26 the the DT cord-023134-y665agnh 558 27 AT AT NNP cord-023134-y665agnh 558 28 remain remain VBP cord-023134-y665agnh 558 29 undisclosed undisclosed JJ cord-023134-y665agnh 558 30 . . . cord-023134-y665agnh 559 1 The the DT cord-023134-y665agnh 559 2 canonical canonical JJ cord-023134-y665agnh 559 3 Wnt Wnt NNP cord-023134-y665agnh 559 4 - - HYPH cord-023134-y665agnh 559 5 pathway pathway NN cord-023134-y665agnh 559 6 plays play VBZ cord-023134-y665agnh 559 7 a a DT cord-023134-y665agnh 559 8 role role NN cord-023134-y665agnh 559 9 in in IN cord-023134-y665agnh 559 10 cell cell NN cord-023134-y665agnh 559 11 survival survival NN cord-023134-y665agnh 559 12 and and CC cord-023134-y665agnh 559 13 cell cell NN cord-023134-y665agnh 559 14 cycle cycle NN cord-023134-y665agnh 559 15 progression progression NN cord-023134-y665agnh 559 16 and and CC cord-023134-y665agnh 559 17 has have VBZ cord-023134-y665agnh 559 18 been be VBN cord-023134-y665agnh 559 19 shown show VBN cord-023134-y665agnh 559 20 to to TO cord-023134-y665agnh 559 21 be be VB cord-023134-y665agnh 559 22 involved involve VBN cord-023134-y665agnh 559 23 in in IN cord-023134-y665agnh 559 24 many many JJ cord-023134-y665agnh 559 25 different different JJ cord-023134-y665agnh 559 26 tumor tumor NN cord-023134-y665agnh 559 27 types type NNS cord-023134-y665agnh 559 28 , , , cord-023134-y665agnh 559 29 including include VBG cord-023134-y665agnh 559 30 human human NN cord-023134-y665agnh 559 31 and and CC cord-023134-y665agnh 559 32 mouse mouse NN cord-023134-y665agnh 559 33 ATs ATs NNP cord-023134-y665agnh 559 34 . . . cord-023134-y665agnh 560 1 Central central JJ cord-023134-y665agnh 560 2 in in IN cord-023134-y665agnh 560 3 this this DT cord-023134-y665agnh 560 4 pathway pathway NN cord-023134-y665agnh 560 5 is be VBZ cord-023134-y665agnh 560 6 ß ß NN cord-023134-y665agnh 560 7 - - HYPH cord-023134-y665agnh 560 8 catenin catenin NNS cord-023134-y665agnh 560 9 . . . cord-023134-y665agnh 561 1 Cytoplasmic Cytoplasmic NNP cord-023134-y665agnh 561 2 and/or and/or CC cord-023134-y665agnh 561 3 nuclear nuclear JJ cord-023134-y665agnh 561 4 accumulation accumulation NN cord-023134-y665agnh 561 5 of of IN cord-023134-y665agnh 561 6 ß ß NN cord-023134-y665agnh 561 7 - - HYPH cord-023134-y665agnh 561 8 catenin catenin NNP cord-023134-y665agnh 561 9 has have VBZ cord-023134-y665agnh 561 10 been be VBN cord-023134-y665agnh 561 11 demonstrated demonstrate VBN cord-023134-y665agnh 561 12 in in IN cord-023134-y665agnh 561 13 human human JJ cord-023134-y665agnh 561 14 cortisol cortisol NN cord-023134-y665agnh 561 15 - - HYPH cord-023134-y665agnh 561 16 secreting secrete VBG cord-023134-y665agnh 561 17 ATs at NNS cord-023134-y665agnh 561 18 . . . cord-023134-y665agnh 562 1 This this DT cord-023134-y665agnh 562 2 has have VBZ cord-023134-y665agnh 562 3 been be VBN cord-023134-y665agnh 562 4 partly partly RB cord-023134-y665agnh 562 5 explained explain VBN cord-023134-y665agnh 562 6 by by IN cord-023134-y665agnh 562 7 mutations mutation NNS cord-023134-y665agnh 562 8 in in IN cord-023134-y665agnh 562 9 exon exon NN cord-023134-y665agnh 562 10 3 3 CD cord-023134-y665agnh 562 11 of of IN cord-023134-y665agnh 562 12 ß ß NN cord-023134-y665agnh 562 13 - - HYPH cord-023134-y665agnh 562 14 catenin catenin NNS cord-023134-y665agnh 562 15 . . . cord-023134-y665agnh 563 1 In in IN cord-023134-y665agnh 563 2 our -PRON- PRP$ cord-023134-y665agnh 563 3 study study NN cord-023134-y665agnh 563 4 , , , cord-023134-y665agnh 563 5 the the DT cord-023134-y665agnh 563 6 activation activation NN cord-023134-y665agnh 563 7 of of IN cord-023134-y665agnh 563 8 the the DT cord-023134-y665agnh 563 9 canonical canonical JJ cord-023134-y665agnh 563 10 Wnt Wnt NNP cord-023134-y665agnh 563 11 - - HYPH cord-023134-y665agnh 563 12 pathway pathway NN cord-023134-y665agnh 563 13 was be VBD cord-023134-y665agnh 563 14 investigated investigate VBN cord-023134-y665agnh 563 15 in in IN cord-023134-y665agnh 563 16 11 11 CD cord-023134-y665agnh 563 17 adrenal adrenal JJ cord-023134-y665agnh 563 18 adenomas adenoma NNS cord-023134-y665agnh 563 19 and and CC cord-023134-y665agnh 563 20 25 25 CD cord-023134-y665agnh 563 21 carcinomas carcinoma NNS cord-023134-y665agnh 563 22 of of IN cord-023134-y665agnh 563 23 dogs dog NNS cord-023134-y665agnh 563 24 with with IN cord-023134-y665agnh 563 25 ACTH ACTH NNP cord-023134-y665agnh 563 26 - - HYPH cord-023134-y665agnh 563 27 independent independent JJ cord-023134-y665agnh 563 28 hypercortisolism hypercortisolism NN cord-023134-y665agnh 563 29 . . . cord-023134-y665agnh 564 1 Fifteen fifteen CD cord-023134-y665agnh 564 2 normal normal JJ cord-023134-y665agnh 564 3 canine canine JJ cord-023134-y665agnh 564 4 adrenals adrenal NNS cord-023134-y665agnh 564 5 served serve VBD cord-023134-y665agnh 564 6 as as IN cord-023134-y665agnh 564 7 control control NN cord-023134-y665agnh 564 8 tissue tissue NN cord-023134-y665agnh 564 9 . . . cord-023134-y665agnh 565 1 The the DT cord-023134-y665agnh 565 2 mRNA mRNA NNP cord-023134-y665agnh 565 3 expression expression NN cord-023134-y665agnh 565 4 was be VBD cord-023134-y665agnh 565 5 measured measure VBN cord-023134-y665agnh 565 6 for for IN cord-023134-y665agnh 565 7 Wnt Wnt NNP cord-023134-y665agnh 565 8 - - HYPH cord-023134-y665agnh 565 9 ligands ligand NNS cord-023134-y665agnh 565 10 ( ( -LRB- cord-023134-y665agnh 565 11 Wnt Wnt NNP cord-023134-y665agnh 565 12 2 2 CD cord-023134-y665agnh 565 13 , , , cord-023134-y665agnh 565 14 Wnt Wnt NNP cord-023134-y665agnh 565 15 3 3 CD cord-023134-y665agnh 565 16 , , , cord-023134-y665agnh 565 17 Wnt Wnt NNP cord-023134-y665agnh 565 18 4 4 CD cord-023134-y665agnh 565 19 , , , cord-023134-y665agnh 565 20 Wnt Wnt NNP cord-023134-y665agnh 565 21 5a 5a CD cord-023134-y665agnh 565 22 , , , cord-023134-y665agnh 565 23 Wnt Wnt NNP cord-023134-y665agnh 565 24 5b 5b NN cord-023134-y665agnh 565 25 variants variant NNS cord-023134-y665agnh 565 26 1 1 CD cord-023134-y665agnh 565 27 and and CC cord-023134-y665agnh 565 28 2 2 CD cord-023134-y665agnh 565 29 , , , cord-023134-y665agnh 565 30 Wnt Wnt NNP cord-023134-y665agnh 565 31 6 6 CD cord-023134-y665agnh 565 32 , , , cord-023134-y665agnh 565 33 Wnt Wnt NNP cord-023134-y665agnh 565 34 7a 7a NN cord-023134-y665agnh 565 35 , , , cord-023134-y665agnh 565 36 Wnt Wnt NNP cord-023134-y665agnh 565 37 10b 10b CD cord-023134-y665agnh 565 38 ) ) -RRB- cord-023134-y665agnh 565 39 , , , cord-023134-y665agnh 565 40 Wnt wnt NN cord-023134-y665agnh 565 41 - - HYPH cord-023134-y665agnh 565 42 ligand ligand NN cord-023134-y665agnh 565 43 inhibitors inhibitor NNS cord-023134-y665agnh 565 44 ( ( -LRB- cord-023134-y665agnh 565 45 DKK DKK NNP cord-023134-y665agnh 565 46 3 3 CD cord-023134-y665agnh 565 47 , , , cord-023134-y665agnh 565 48 WIF WIF NNP cord-023134-y665agnh 565 49 1 1 CD cord-023134-y665agnh 565 50 , , , cord-023134-y665agnh 565 51 sFRP sfrp NN cord-023134-y665agnh 565 52 1 1 CD cord-023134-y665agnh 565 53 ) ) -RRB- cord-023134-y665agnh 565 54 and and CC cord-023134-y665agnh 565 55 for for IN cord-023134-y665agnh 565 56 Wnt Wnt NNP cord-023134-y665agnh 565 57 target target VB cord-023134-y665agnh 565 58 genes gene NNS cord-023134-y665agnh 565 59 ( ( -LRB- cord-023134-y665agnh 565 60 cMyc cMyc NNP cord-023134-y665agnh 565 61 , , , cord-023134-y665agnh 566 1 Axin2 Axin2 NNP cord-023134-y665agnh 566 2 and and CC cord-023134-y665agnh 566 3 CyclinD1 cyclind1 NN cord-023134-y665agnh 566 4 ) ) -RRB- cord-023134-y665agnh 567 1 . . . cord-023134-y665agnh 568 1 In in IN cord-023134-y665agnh 568 2 addition addition NN cord-023134-y665agnh 568 3 , , , cord-023134-y665agnh 568 4 the the DT cord-023134-y665agnh 568 5 coding code VBG cord-023134-y665agnh 568 6 region region NN cord-023134-y665agnh 568 7 of of IN cord-023134-y665agnh 568 8 the the DT cord-023134-y665agnh 568 9 mRNA mrna NN cord-023134-y665agnh 568 10 of of IN cord-023134-y665agnh 568 11 ß ß NN cord-023134-y665agnh 568 12 - - HYPH cord-023134-y665agnh 568 13 catenin catenin NNP cord-023134-y665agnh 568 14 was be VBD cord-023134-y665agnh 568 15 sequenced sequence VBN cord-023134-y665agnh 568 16 and and CC cord-023134-y665agnh 568 17 the the DT cord-023134-y665agnh 568 18 localization localization NN cord-023134-y665agnh 568 19 of of IN cord-023134-y665agnh 568 20 ß ß NN cord-023134-y665agnh 568 21 - - HYPH cord-023134-y665agnh 568 22 catenin catenin NNP cord-023134-y665agnh 568 23 was be VBD cord-023134-y665agnh 568 24 evaluated evaluate VBN cord-023134-y665agnh 568 25 by by IN cord-023134-y665agnh 568 26 immunohistochemistry immunohistochemistry FW cord-023134-y665agnh 568 27 ( ( -LRB- cord-023134-y665agnh 568 28 IHC).The ihc).the CD cord-023134-y665agnh 568 29 results result NNS cord-023134-y665agnh 568 30 of of IN cord-023134-y665agnh 568 31 expression expression NN cord-023134-y665agnh 568 32 analysis analysis NN cord-023134-y665agnh 568 33 of of IN cord-023134-y665agnh 568 34 Wnt Wnt NNP cord-023134-y665agnh 568 35 - - HYPH cord-023134-y665agnh 568 36 ligands ligand NNS cord-023134-y665agnh 568 37 and and CC cord-023134-y665agnh 568 38 Wnt Wnt NNP cord-023134-y665agnh 568 39 - - HYPH cord-023134-y665agnh 568 40 ligand ligand NN cord-023134-y665agnh 568 41 inhibitors inhibitor NNS cord-023134-y665agnh 568 42 demonstrated demonstrate VBD cord-023134-y665agnh 568 43 a a DT cord-023134-y665agnh 568 44 significant significant JJ cord-023134-y665agnh 568 45 downregulation downregulation NN cord-023134-y665agnh 568 46 of of IN cord-023134-y665agnh 568 47 Wnt Wnt NNP cord-023134-y665agnh 568 48 4 4 CD cord-023134-y665agnh 568 49 and and CC cord-023134-y665agnh 568 50 Wnt Wnt NNP cord-023134-y665agnh 568 51 5b 5b NN cord-023134-y665agnh 568 52 variants variant NNS cord-023134-y665agnh 568 53 1 1 CD cord-023134-y665agnh 568 54 and and CC cord-023134-y665agnh 568 55 2 2 CD cord-023134-y665agnh 568 56 . . . cord-023134-y665agnh 569 1 Wnt wnt VB cord-023134-y665agnh 569 2 target target VB cord-023134-y665agnh 569 3 gene gene NN cord-023134-y665agnh 569 4 cyclin cyclin NN cord-023134-y665agnh 569 5 D1 d1 NN cord-023134-y665agnh 569 6 was be VBD cord-023134-y665agnh 569 7 significantly significantly RB cord-023134-y665agnh 569 8 downregulated downregulate VBN cord-023134-y665agnh 569 9 in in IN cord-023134-y665agnh 569 10 adenomas adenoma NNS cord-023134-y665agnh 569 11 , , , cord-023134-y665agnh 569 12 while while IN cord-023134-y665agnh 569 13 cMyc cMyc NNP cord-023134-y665agnh 569 14 and and CC cord-023134-y665agnh 569 15 Axin Axin NNP cord-023134-y665agnh 569 16 2 2 CD cord-023134-y665agnh 570 1 mRNA mRNA NNP cord-023134-y665agnh 570 2 expression expression NN cord-023134-y665agnh 570 3 did do VBD cord-023134-y665agnh 570 4 not not RB cord-023134-y665agnh 570 5 differ differ VB cord-023134-y665agnh 570 6 between between IN cord-023134-y665agnh 570 7 ATs at NNS cord-023134-y665agnh 570 8 and and CC cord-023134-y665agnh 570 9 normal normal JJ cord-023134-y665agnh 570 10 adrenals adrenal NNS cord-023134-y665agnh 570 11 . . . cord-023134-y665agnh 571 1 Sequence sequence NN cord-023134-y665agnh 571 2 analysis analysis NN cord-023134-y665agnh 571 3 of of IN cord-023134-y665agnh 571 4 ß ß NN cord-023134-y665agnh 571 5 - - HYPH cord-023134-y665agnh 571 6 catenin catenin NNP cord-023134-y665agnh 571 7 revealed reveal VBD cord-023134-y665agnh 571 8 a a DT cord-023134-y665agnh 571 9 mutation mutation NN cord-023134-y665agnh 571 10 in in IN cord-023134-y665agnh 571 11 12/36 12/36 CD cord-023134-y665agnh 571 12 of of IN cord-023134-y665agnh 571 13 the the DT cord-023134-y665agnh 571 14 ATs at NNS cord-023134-y665agnh 571 15 : : : cord-023134-y665agnh 571 16 9 9 CD cord-023134-y665agnh 571 17 silent silent JJ cord-023134-y665agnh 571 18 mutations mutation NNS cord-023134-y665agnh 571 19 , , , cord-023134-y665agnh 571 20 most most RBS cord-023134-y665agnh 571 21 probably probably RB cord-023134-y665agnh 571 22 single single JJ cord-023134-y665agnh 571 23 nucleotide nucleotide JJ cord-023134-y665agnh 571 24 polymorphisms polymorphism NNS cord-023134-y665agnh 571 25 ( ( -LRB- cord-023134-y665agnh 571 26 SNPs SNPs NNP cord-023134-y665agnh 571 27 ) ) -RRB- cord-023134-y665agnh 571 28 , , , cord-023134-y665agnh 571 29 1 1 CD cord-023134-y665agnh 571 30 neutral neutral JJ cord-023134-y665agnh 571 31 mutation mutation NN cord-023134-y665agnh 571 32 ( ( -LRB- cord-023134-y665agnh 571 33 Arginine arginine NN cord-023134-y665agnh 571 34 to to IN cord-023134-y665agnh 571 35 Histidine Histidine NNP cord-023134-y665agnh 571 36 ) ) -RRB- cord-023134-y665agnh 571 37 , , , cord-023134-y665agnh 571 38 1 1 CD cord-023134-y665agnh 571 39 nonsense nonsense NN cord-023134-y665agnh 571 40 mutation mutation NN cord-023134-y665agnh 571 41 resulting result VBG cord-023134-y665agnh 571 42 in in IN cord-023134-y665agnh 571 43 a a DT cord-023134-y665agnh 571 44 premature premature JJ cord-023134-y665agnh 571 45 stop stop NN cord-023134-y665agnh 571 46 codon codon NN cord-023134-y665agnh 571 47 and and CC cord-023134-y665agnh 571 48 1 1 CD cord-023134-y665agnh 571 49 deletion deletion NN cord-023134-y665agnh 571 50 of of IN cord-023134-y665agnh 571 51 26 26 CD cord-023134-y665agnh 571 52 basepairs basepair NNS cord-023134-y665agnh 571 53 combined combine VBN cord-023134-y665agnh 571 54 with with IN cord-023134-y665agnh 571 55 a a DT cord-023134-y665agnh 571 56 neutral neutral JJ cord-023134-y665agnh 571 57 mutation mutation NN cord-023134-y665agnh 571 58 . . . cord-023134-y665agnh 572 1 The the DT cord-023134-y665agnh 572 2 amino amino NN cord-023134-y665agnh 572 3 acid acid NN cord-023134-y665agnh 572 4 change change NN cord-023134-y665agnh 572 5 appeared appear VBD cord-023134-y665agnh 572 6 not not RB cord-023134-y665agnh 572 7 to to TO cord-023134-y665agnh 572 8 be be VB cord-023134-y665agnh 572 9 tumorassociated tumorassociate VBN cord-023134-y665agnh 572 10 whereas whereas IN cord-023134-y665agnh 572 11 the the DT cord-023134-y665agnh 572 12 stop stop NN cord-023134-y665agnh 572 13 codon codon NN cord-023134-y665agnh 572 14 was be VBD cord-023134-y665agnh 572 15 . . . cord-023134-y665agnh 573 1 There there EX cord-023134-y665agnh 573 2 were be VBD cord-023134-y665agnh 573 3 no no DT cord-023134-y665agnh 573 4 activating activate VBG cord-023134-y665agnh 573 5 ß ß NN cord-023134-y665agnh 573 6 - - HYPH cord-023134-y665agnh 573 7 catenin catenin NNS cord-023134-y665agnh 573 8 mutations mutation NNS cord-023134-y665agnh 573 9 . . . cord-023134-y665agnh 574 1 The the DT cord-023134-y665agnh 574 2 IHC IHC NNP cord-023134-y665agnh 574 3 demonstrated demonstrate VBD cord-023134-y665agnh 574 4 accumulation accumulation NN cord-023134-y665agnh 574 5 of of IN cord-023134-y665agnh 574 6 ß ß NN cord-023134-y665agnh 574 7 - - HYPH cord-023134-y665agnh 574 8 catenin catenin NNS cord-023134-y665agnh 574 9 in in IN cord-023134-y665agnh 574 10 the the DT cord-023134-y665agnh 574 11 cytoplasm cytoplasm NN cord-023134-y665agnh 574 12 of of IN cord-023134-y665agnh 574 13 part part NN cord-023134-y665agnh 574 14 of of IN cord-023134-y665agnh 574 15 the the DT cord-023134-y665agnh 574 16 ATs at NNS cord-023134-y665agnh 574 17 , , , cord-023134-y665agnh 574 18 while while IN cord-023134-y665agnh 574 19 nuclear nuclear JJ cord-023134-y665agnh 574 20 staining staining NN cord-023134-y665agnh 574 21 for for IN cord-023134-y665agnh 574 22 ß ß NN cord-023134-y665agnh 574 23 - - HYPH cord-023134-y665agnh 574 24 catenin catenin NNP cord-023134-y665agnh 574 25 was be VBD cord-023134-y665agnh 574 26 rarely rarely RB cord-023134-y665agnh 574 27 present present JJ cord-023134-y665agnh 574 28 . . . cord-023134-y665agnh 575 1 We -PRON- PRP cord-023134-y665agnh 575 2 conclude conclude VBP cord-023134-y665agnh 575 3 that that IN cord-023134-y665agnh 575 4 the the DT cord-023134-y665agnh 575 5 canonical canonical JJ cord-023134-y665agnh 575 6 Wnt Wnt NNP cord-023134-y665agnh 575 7 - - HYPH cord-023134-y665agnh 575 8 pathway pathway NN cord-023134-y665agnh 575 9 is be VBZ cord-023134-y665agnh 575 10 most most RBS cord-023134-y665agnh 575 11 likely likely RB cord-023134-y665agnh 575 12 not not RB cord-023134-y665agnh 575 13 involved involve VBN cord-023134-y665agnh 575 14 in in IN cord-023134-y665agnh 575 15 the the DT cord-023134-y665agnh 575 16 pathogenesis pathogenesis NN cord-023134-y665agnh 575 17 of of IN cord-023134-y665agnh 575 18 canine canine JJ cord-023134-y665agnh 575 19 cortisol cortisol NN cord-023134-y665agnh 575 20 - - HYPH cord-023134-y665agnh 575 21 secreting secrete VBG cord-023134-y665agnh 575 22 ATs at NNS cord-023134-y665agnh 575 23 . . . cord-023134-y665agnh 576 1 Trilostane Trilostane NNP cord-023134-y665agnh 576 2 is be VBZ cord-023134-y665agnh 576 3 the the DT cord-023134-y665agnh 576 4 treatment treatment NN cord-023134-y665agnh 576 5 of of IN cord-023134-y665agnh 576 6 choice choice NN cord-023134-y665agnh 576 7 for for IN cord-023134-y665agnh 576 8 canine canine JJ cord-023134-y665agnh 576 9 pituitary pituitary NN cord-023134-y665agnh 576 10 - - HYPH cord-023134-y665agnh 576 11 dependent dependent JJ cord-023134-y665agnh 576 12 hyperadrenocorticism hyperadrenocorticism NN cord-023134-y665agnh 576 13 ( ( -LRB- cord-023134-y665agnh 576 14 PDH PDH NNP cord-023134-y665agnh 576 15 ) ) -RRB- cord-023134-y665agnh 577 1 however however RB cord-023134-y665agnh 577 2 there there EX cord-023134-y665agnh 577 3 is be VBZ cord-023134-y665agnh 577 4 controversy controversy NN cord-023134-y665agnh 577 5 about about IN cord-023134-y665agnh 577 6 the the DT cord-023134-y665agnh 577 7 ideal ideal JJ cord-023134-y665agnh 577 8 treatment treatment NN cord-023134-y665agnh 577 9 regime regime NN cord-023134-y665agnh 577 10 . . . cord-023134-y665agnh 578 1 The the DT cord-023134-y665agnh 578 2 objective objective NN cord-023134-y665agnh 578 3 of of IN cord-023134-y665agnh 578 4 this this DT cord-023134-y665agnh 578 5 study study NN cord-023134-y665agnh 578 6 was be VBD cord-023134-y665agnh 578 7 to to TO cord-023134-y665agnh 578 8 evaluate evaluate VB cord-023134-y665agnh 578 9 efficacy efficacy NN cord-023134-y665agnh 578 10 and and CC cord-023134-y665agnh 578 11 safety safety NN cord-023134-y665agnh 578 12 of of IN cord-023134-y665agnh 578 13 SID SID NNP cord-023134-y665agnh 579 1 vs vs IN cord-023134-y665agnh 579 2 BID BID NNP cord-023134-y665agnh 579 3 trilostane trilostane NNP cord-023134-y665agnh 579 4 treatment treatment NN cord-023134-y665agnh 579 5 for for IN cord-023134-y665agnh 579 6 canine canine JJ cord-023134-y665agnh 579 7 PDH.This PDH.This NNP cord-023134-y665agnh 579 8 prospective prospective JJ cord-023134-y665agnh 579 9 randomised randomised JJ cord-023134-y665agnh 579 10 study study NN cord-023134-y665agnh 579 11 included include VBD cord-023134-y665agnh 579 12 32 32 CD cord-023134-y665agnh 579 13 dogs dog NNS cord-023134-y665agnh 579 14 with with IN cord-023134-y665agnh 579 15 PDH PDH NNP cord-023134-y665agnh 579 16 , , , cord-023134-y665agnh 579 17 16 16 CD cord-023134-y665agnh 579 18 dogs dog NNS cord-023134-y665agnh 579 19 treated treat VBN cord-023134-y665agnh 579 20 with with IN cord-023134-y665agnh 579 21 trilostane trilostane NNP cord-023134-y665agnh 580 1 SID SID NNP cord-023134-y665agnh 580 2 ( ( -LRB- cord-023134-y665agnh 580 3 initial initial JJ cord-023134-y665agnh 580 4 dose dose NN cord-023134-y665agnh 580 5 1 1 CD cord-023134-y665agnh 580 6 - - SYM cord-023134-y665agnh 580 7 6 6 CD cord-023134-y665agnh 580 8 mg mg NNP cord-023134-y665agnh 580 9 / / SYM cord-023134-y665agnh 580 10 kg/24 kg/24 NNP cord-023134-y665agnh 580 11 hrs hrs NN cord-023134-y665agnh 580 12 ) ) -RRB- cord-023134-y665agnh 580 13 and and CC cord-023134-y665agnh 580 14 16 16 CD cord-023134-y665agnh 580 15 with with IN cord-023134-y665agnh 580 16 trilostane trilostane NNP cord-023134-y665agnh 580 17 BID BID NNP cord-023134-y665agnh 580 18 ( ( -LRB- cord-023134-y665agnh 580 19 0.5 0.5 CD cord-023134-y665agnh 580 20 - - SYM cord-023134-y665agnh 580 21 3 3 CD cord-023134-y665agnh 580 22 mg mg NNP cord-023134-y665agnh 580 23 / / SYM cord-023134-y665agnh 580 24 kg/12 kg/12 NNP cord-023134-y665agnh 580 25 hrs hrs NN cord-023134-y665agnh 580 26 ) ) -RRB- cord-023134-y665agnh 580 27 . . . cord-023134-y665agnh 581 1 A a DT cord-023134-y665agnh 581 2 history history NN cord-023134-y665agnh 581 3 , , , cord-023134-y665agnh 581 4 physical physical JJ cord-023134-y665agnh 581 5 exam exam NN cord-023134-y665agnh 581 6 , , , cord-023134-y665agnh 581 7 haemogram haemogram NNP cord-023134-y665agnh 581 8 , , , cord-023134-y665agnh 581 9 biochemical biochemical JJ cord-023134-y665agnh 581 10 profile profile NN cord-023134-y665agnh 581 11 , , , cord-023134-y665agnh 581 12 ACTH ACTH NNP cord-023134-y665agnh 581 13 stimulation stimulation NN cord-023134-y665agnh 581 14 test test NN cord-023134-y665agnh 581 15 and and CC cord-023134-y665agnh 581 16 urinary urinary JJ cord-023134-y665agnh 581 17 cortisol cortisol NN cord-023134-y665agnh 581 18 to to IN cord-023134-y665agnh 581 19 creatinine creatinine NN cord-023134-y665agnh 581 20 ratios ratio NNS cord-023134-y665agnh 581 21 ( ( -LRB- cord-023134-y665agnh 581 22 UCCR UCCR NNP cord-023134-y665agnh 581 23 ) ) -RRB- cord-023134-y665agnh 581 24 were be VBD cord-023134-y665agnh 581 25 performed perform VBN cord-023134-y665agnh 581 26 before before IN cord-023134-y665agnh 581 27 treatment treatment NN cord-023134-y665agnh 581 28 , , , cord-023134-y665agnh 581 29 and and CC cord-023134-y665agnh 581 30 at at IN cord-023134-y665agnh 581 31 one one CD cord-023134-y665agnh 581 32 week week NN cord-023134-y665agnh 581 33 ( ( -LRB- cord-023134-y665agnh 581 34 SID SID NNP cord-023134-y665agnh 581 35 8 8 CD cord-023134-y665agnh 581 36 - - SYM cord-023134-y665agnh 581 37 12 12 CD cord-023134-y665agnh 581 38 hrs hrs NN cord-023134-y665agnh 581 39 post post NN cord-023134-y665agnh 581 40 trilostane trilostane NN cord-023134-y665agnh 581 41 ; ; . cord-023134-y665agnh 582 1 BID BID NNP cord-023134-y665agnh 582 2 4 4 CD cord-023134-y665agnh 582 3 - - SYM cord-023134-y665agnh 582 4 6 6 CD cord-023134-y665agnh 582 5 hrs hrs NN cord-023134-y665agnh 582 6 ) ) -RRB- cord-023134-y665agnh 582 7 and and CC cord-023134-y665agnh 582 8 1 1 CD cord-023134-y665agnh 582 9 , , , cord-023134-y665agnh 582 10 3 3 CD cord-023134-y665agnh 582 11 , , , cord-023134-y665agnh 582 12 6 6 CD cord-023134-y665agnh 582 13 and and CC cord-023134-y665agnh 582 14 12 12 CD cord-023134-y665agnh 582 15 months month NNS cord-023134-y665agnh 582 16 after after IN cord-023134-y665agnh 582 17 treatment treatment NN cord-023134-y665agnh 583 1 ( ( -LRB- cord-023134-y665agnh 583 2 8 8 CD cord-023134-y665agnh 583 3 - - SYM cord-023134-y665agnh 583 4 12 12 CD cord-023134-y665agnh 583 5 hrs hrs NN cord-023134-y665agnh 583 6 post post NN cord-023134-y665agnh 584 1 medication)The medication)the DT cord-023134-y665agnh 584 2 median median NN cord-023134-y665agnh 584 3 ( ( -LRB- cord-023134-y665agnh 584 4 ±SD ±sd RB cord-023134-y665agnh 584 5 ) ) -RRB- cord-023134-y665agnh 585 1 daily daily RB cord-023134-y665agnh 585 2 dose dose NN cord-023134-y665agnh 585 3 throughout throughout IN cord-023134-y665agnh 585 4 the the DT cord-023134-y665agnh 585 5 study study NN cord-023134-y665agnh 585 6 was be VBD cord-023134-y665agnh 585 7 similar similar JJ cord-023134-y665agnh 585 8 in in IN cord-023134-y665agnh 585 9 dogs dog NNS cord-023134-y665agnh 585 10 receiving receive VBG cord-023134-y665agnh 585 11 SID SID NNP cord-023134-y665agnh 585 12 ( ( -LRB- cord-023134-y665agnh 585 13 3.7±2.1 3.7±2.1 NNP cord-023134-y665agnh 585 14 mg mg NNP cord-023134-y665agnh 585 15 / / SYM cord-023134-y665agnh 585 16 kg kg NNP cord-023134-y665agnh 585 17 / / SYM cord-023134-y665agnh 585 18 day day NN cord-023134-y665agnh 585 19 ) ) -RRB- cord-023134-y665agnh 585 20 or or CC cord-023134-y665agnh 585 21 BID bid VB cord-023134-y665agnh 585 22 ( ( -LRB- cord-023134-y665agnh 585 23 3.8±0.8 3.8±0.8 NNP cord-023134-y665agnh 585 24 mg mg NNP cord-023134-y665agnh 585 25 / / SYM cord-023134-y665agnh 585 26 kg kg NNP cord-023134-y665agnh 585 27 / / SYM cord-023134-y665agnh 585 28 day day NN cord-023134-y665agnh 585 29 ) ) -RRB- cord-023134-y665agnh 585 30 trilostane trilostane NNP cord-023134-y665agnh 585 31 . . . cord-023134-y665agnh 586 1 Baseline baseline JJ cord-023134-y665agnh 586 2 cortisol cortisol NN cord-023134-y665agnh 586 3 concentration concentration NN cord-023134-y665agnh 586 4 ( ( -LRB- cord-023134-y665agnh 586 5 mean±SD mean±SD NNP cord-023134-y665agnh 586 6 ) ) -RRB- cord-023134-y665agnh 586 7 before before IN cord-023134-y665agnh 586 8 trilostane trilostane NNP cord-023134-y665agnh 586 9 and and CC cord-023134-y665agnh 586 10 at at IN cord-023134-y665agnh 586 11 the the DT cord-023134-y665agnh 586 12 five five CD cord-023134-y665agnh 586 13 reevaluations reevaluation NNS cord-023134-y665agnh 586 14 in in IN cord-023134-y665agnh 586 15 the the DT cord-023134-y665agnh 586 16 SID SID NNP cord-023134-y665agnh 586 17 group group NN cord-023134-y665agnh 586 18 were be VBD cord-023134-y665agnh 586 19 6.9±2.4 6.9±2.4 CD cord-023134-y665agnh 586 20 , , , cord-023134-y665agnh 586 21 3.9±2.5 3.9±2.5 NNP cord-023134-y665agnh 586 22 , , , cord-023134-y665agnh 586 23 4.3±1.9 4.3±1.9 CD cord-023134-y665agnh 586 24 , , , cord-023134-y665agnh 586 25 4.4±1.5 4.4±1.5 CD cord-023134-y665agnh 586 26 , , , cord-023134-y665agnh 586 27 5.0±2.0 5.0±2.0 CD cord-023134-y665agnh 586 28 and and CC cord-023134-y665agnh 586 29 2.2±0.7 2.2±0.7 CD cord-023134-y665agnh 586 30 and and CC cord-023134-y665agnh 586 31 in in IN cord-023134-y665agnh 586 32 the the DT cord-023134-y665agnh 586 33 BID BID NNP cord-023134-y665agnh 586 34 group group NN cord-023134-y665agnh 586 35 were be VBD cord-023134-y665agnh 586 36 6.4±3.9 6.4±3.9 CD cord-023134-y665agnh 586 37 lg lg NNP cord-023134-y665agnh 586 38 / / SYM cord-023134-y665agnh 586 39 dl dl NNP cord-023134-y665agnh 586 40 , , , cord-023134-y665agnh 586 41 3.1±1.4 3.1±1.4 NNP cord-023134-y665agnh 586 42 , , , cord-023134-y665agnh 586 43 3.7±2.1 3.7±2.1 CD cord-023134-y665agnh 586 44 , , , cord-023134-y665agnh 586 45 3.6±1.7 3.6±1.7 CD cord-023134-y665agnh 586 46 , , , cord-023134-y665agnh 586 47 3.3±1.6 3.3±1.6 CD cord-023134-y665agnh 586 48 and and CC cord-023134-y665agnh 586 49 2.5±1.5 2.5±1.5 CD cord-023134-y665agnh 586 50 . . . cord-023134-y665agnh 587 1 Baseline baseline JJ cord-023134-y665agnh 587 2 cortisol cortisol NN cord-023134-y665agnh 587 3 was be VBD cord-023134-y665agnh 587 4 significantly significantly RB cord-023134-y665agnh 587 5 higher high JJR cord-023134-y665agnh 587 6 ( ( -LRB- cord-023134-y665agnh 587 7 p=0.023 p=0.023 NNS cord-023134-y665agnh 587 8 ) ) -RRB- cord-023134-y665agnh 587 9 in in IN cord-023134-y665agnh 587 10 the the DT cord-023134-y665agnh 587 11 SID SID NNP cord-023134-y665agnh 587 12 group group NN cord-023134-y665agnh 587 13 only only RB cord-023134-y665agnh 587 14 at at IN cord-023134-y665agnh 587 15 six six CD cord-023134-y665agnh 587 16 - - HYPH cord-023134-y665agnh 587 17 month month NN cord-023134-y665agnh 587 18 evaluation evaluation NN cord-023134-y665agnh 587 19 . . . cord-023134-y665agnh 588 1 Post Post NNP cord-023134-y665agnh 588 2 ACTH ACTH NNP cord-023134-y665agnh 588 3 cortisol cortisol NN cord-023134-y665agnh 588 4 concentrations concentration NNS cord-023134-y665agnh 588 5 in in IN cord-023134-y665agnh 588 6 the the DT cord-023134-y665agnh 588 7 SID SID NNP cord-023134-y665agnh 588 8 group group NN cord-023134-y665agnh 588 9 were be VBD cord-023134-y665agnh 588 10 29.8±13.2 29.8±13.2 CD cord-023134-y665agnh 588 11 , , , cord-023134-y665agnh 588 12 10.3±5.6 10.3±5.6 CD cord-023134-y665agnh 588 13 , , , cord-023134-y665agnh 588 14 12.1±5.8 12.1±5.8 CD cord-023134-y665agnh 588 15 , , , cord-023134-y665agnh 588 16 10.3±2.2 10.3±2.2 CD cord-023134-y665agnh 588 17 , , , cord-023134-y665agnh 588 18 8.8±4.9 8.8±4.9 CD cord-023134-y665agnh 588 19 and and CC cord-023134-y665agnh 588 20 4.2±2.2 4.2±2.2 CD cord-023134-y665agnh 588 21 and and CC cord-023134-y665agnh 588 22 in in IN cord-023134-y665agnh 588 23 the the DT cord-023134-y665agnh 588 24 BID BID NNP cord-023134-y665agnh 588 25 group group NN cord-023134-y665agnh 588 26 were be VBD cord-023134-y665agnh 588 27 32 32 CD cord-023134-y665agnh 588 28 . . . cord-023134-y665agnh 589 1 7±12.4 7±12.4 NNP cord-023134-y665agnh 589 2 , , , cord-023134-y665agnh 589 3 8.6±6.8 8.6±6.8 CD cord-023134-y665agnh 589 4 , , , cord-023134-y665agnh 589 5 8.6±4.8 8.6±4.8 CD cord-023134-y665agnh 589 6 , , , cord-023134-y665agnh 589 7 8.3±4.4 8.3±4.4 CD cord-023134-y665agnh 589 8 , , , cord-023134-y665agnh 589 9 8.9±4 8.9±4 CD cord-023134-y665agnh 589 10 .9 .9 CD cord-023134-y665agnh 589 11 and and CC cord-023134-y665agnh 589 12 7.6±7.2 7.6±7.2 NNP cord-023134-y665agnh 589 13 . . . cord-023134-y665agnh 590 1 No no DT cord-023134-y665agnh 590 2 statistically statistically RB cord-023134-y665agnh 590 3 significant significant JJ cord-023134-y665agnh 590 4 differences difference NNS cord-023134-y665agnh 590 5 were be VBD cord-023134-y665agnh 590 6 found find VBN cord-023134-y665agnh 590 7 at at IN cord-023134-y665agnh 590 8 any any DT cord-023134-y665agnh 590 9 evaluation evaluation NN cord-023134-y665agnh 590 10 . . . cord-023134-y665agnh 591 1 UCCR UCCR NNP cord-023134-y665agnh 591 2 in in IN cord-023134-y665agnh 591 3 dogs dog NNS cord-023134-y665agnh 591 4 in in IN cord-023134-y665agnh 591 5 the the DT cord-023134-y665agnh 591 6 SID SID NNP cord-023134-y665agnh 591 7 group group NN cord-023134-y665agnh 591 8 were be VBD cord-023134-y665agnh 591 9 480±509 480±509 CD cord-023134-y665agnh 591 10 , , , cord-023134-y665agnh 591 11 241±163 241±163 CD cord-023134-y665agnh 591 12 , , , cord-023134-y665agnh 591 13 306±201 306±201 CD cord-023134-y665agnh 591 14 , , , cord-023134-y665agnh 591 15 224±104 224±104 CD cord-023134-y665agnh 591 16 , , , cord-023134-y665agnh 591 17 186±119 186±119 CD cord-023134-y665agnh 591 18 and and CC cord-023134-y665agnh 591 19 107±66.8 107±66.8 CD cord-023134-y665agnh 591 20 and and CC cord-023134-y665agnh 591 21 in in IN cord-023134-y665agnh 591 22 the the DT cord-023134-y665agnh 591 23 BID BID NNP cord-023134-y665agnh 591 24 group group NN cord-023134-y665agnh 591 25 270±278 270±278 CD cord-023134-y665agnh 591 26 , , , cord-023134-y665agnh 591 27 225±172 225±172 CD cord-023134-y665agnh 591 28 , , , cord-023134-y665agnh 591 29 222±178 222±178 CD cord-023134-y665agnh 591 30 , , , cord-023134-y665agnh 591 31 237±108 237±108 CD cord-023134-y665agnh 591 32 , , , cord-023134-y665agnh 591 33 157±62 157±62 CD cord-023134-y665agnh 591 34 and and CC cord-023134-y665agnh 591 35 102±11 102±11 CD cord-023134-y665agnh 591 36 . . . cord-023134-y665agnh 592 1 Similarly similarly RB cord-023134-y665agnh 592 2 no no DT cord-023134-y665agnh 592 3 statistically statistically RB cord-023134-y665agnh 592 4 significant significant JJ cord-023134-y665agnh 592 5 differences difference NNS cord-023134-y665agnh 592 6 were be VBD cord-023134-y665agnh 592 7 found find VBN cord-023134-y665agnh 592 8 throughout throughout IN cord-023134-y665agnh 592 9 the the DT cord-023134-y665agnh 592 10 study study NN cord-023134-y665agnh 592 11 . . . cord-023134-y665agnh 593 1 In in IN cord-023134-y665agnh 593 2 each each DT cord-023134-y665agnh 593 3 of of IN cord-023134-y665agnh 593 4 the the DT cord-023134-y665agnh 593 5 five five CD cord-023134-y665agnh 593 6 re re NN cord-023134-y665agnh 593 7 - - NN cord-023134-y665agnh 593 8 evaluation evaluation NN cord-023134-y665agnh 593 9 times time NNS cord-023134-y665agnh 593 10 , , , cord-023134-y665agnh 593 11 clinical clinical JJ cord-023134-y665agnh 593 12 signs sign NNS cord-023134-y665agnh 593 13 ( ( -LRB- cord-023134-y665agnh 593 14 polyuria polyuria NN cord-023134-y665agnh 593 15 , , , cord-023134-y665agnh 593 16 polydipsia polydipsia NN cord-023134-y665agnh 593 17 and/or and/or CC cord-023134-y665agnh 593 18 polyphagia polyphagia NNP cord-023134-y665agnh 593 19 ) ) -RRB- cord-023134-y665agnh 593 20 persisted persist VBD cord-023134-y665agnh 593 21 in in IN cord-023134-y665agnh 593 22 73 73 CD cord-023134-y665agnh 593 23 % % NN cord-023134-y665agnh 593 24 ( ( -LRB- cord-023134-y665agnh 593 25 11/15 11/15 CD cord-023134-y665agnh 593 26 ) ) -RRB- cord-023134-y665agnh 593 27 , , , cord-023134-y665agnh 593 28 62 62 CD cord-023134-y665agnh 593 29 % % NN cord-023134-y665agnh 593 30 ( ( -LRB- cord-023134-y665agnh 593 31 8/13 8/13 CD cord-023134-y665agnh 593 32 ) ) -RRB- cord-023134-y665agnh 593 33 , , , cord-023134-y665agnh 593 34 57 57 CD cord-023134-y665agnh 593 35 % % NN cord-023134-y665agnh 593 36 ( ( -LRB- cord-023134-y665agnh 593 37 8/14 8/14 CD cord-023134-y665agnh 593 38 ) ) -RRB- cord-023134-y665agnh 593 39 , , , cord-023134-y665agnh 593 40 58 58 CD cord-023134-y665agnh 593 41 % % NN cord-023134-y665agnh 593 42 ( ( -LRB- cord-023134-y665agnh 593 43 7/12 7/12 CD cord-023134-y665agnh 593 44 ) ) -RRB- cord-023134-y665agnh 593 45 and and CC cord-023134-y665agnh 593 46 in in IN cord-023134-y665agnh 593 47 63 63 CD cord-023134-y665agnh 593 48 % % NN cord-023134-y665agnh 593 49 ( ( -LRB- cord-023134-y665agnh 593 50 5/8 5/8 CD cord-023134-y665agnh 593 51 ) ) -RRB- cord-023134-y665agnh 593 52 of of IN cord-023134-y665agnh 593 53 dogs dog NNS cord-023134-y665agnh 593 54 in in IN cord-023134-y665agnh 593 55 the the DT cord-023134-y665agnh 593 56 SID SID NNP cord-023134-y665agnh 593 57 group group NN cord-023134-y665agnh 593 58 . . . cord-023134-y665agnh 594 1 Persistence persistence NN cord-023134-y665agnh 594 2 of of IN cord-023134-y665agnh 594 3 clinical clinical JJ cord-023134-y665agnh 594 4 signs sign NNS cord-023134-y665agnh 594 5 occurred occur VBD cord-023134-y665agnh 594 6 in in IN cord-023134-y665agnh 594 7 46 46 CD cord-023134-y665agnh 594 8 % % NN cord-023134-y665agnh 594 9 ( ( -LRB- cord-023134-y665agnh 594 10 6/13 6/13 CD cord-023134-y665agnh 594 11 ) ) -RRB- cord-023134-y665agnh 594 12 , , , cord-023134-y665agnh 594 13 27 27 CD cord-023134-y665agnh 594 14 % % NN cord-023134-y665agnh 594 15 ( ( -LRB- cord-023134-y665agnh 594 16 3/11 3/11 CD cord-023134-y665agnh 594 17 ) ) -RRB- cord-023134-y665agnh 594 18 , , , cord-023134-y665agnh 594 19 41 41 CD cord-023134-y665agnh 594 20 % % NN cord-023134-y665agnh 594 21 ( ( -LRB- cord-023134-y665agnh 594 22 6/15 6/15 CD cord-023134-y665agnh 594 23 ) ) -RRB- cord-023134-y665agnh 594 24 , , , cord-023134-y665agnh 594 25 25 25 CD cord-023134-y665agnh 594 26 % % NN cord-023134-y665agnh 594 27 ( ( -LRB- cord-023134-y665agnh 594 28 4/16 4/16 CD cord-023134-y665agnh 594 29 ) ) -RRB- cord-023134-y665agnh 594 30 and and CC cord-023134-y665agnh 594 31 0 0 CD cord-023134-y665agnh 594 32 % % NN cord-023134-y665agnh 594 33 ( ( -LRB- cord-023134-y665agnh 594 34 0/12 0/12 CD cord-023134-y665agnh 594 35 ) ) -RRB- cord-023134-y665agnh 594 36 of of IN cord-023134-y665agnh 594 37 dogs dog NNS cord-023134-y665agnh 594 38 in in IN cord-023134-y665agnh 594 39 the the DT cord-023134-y665agnh 594 40 BID BID NNP cord-023134-y665agnh 594 41 group group NN cord-023134-y665agnh 594 42 . . . cord-023134-y665agnh 595 1 Mild mild JJ cord-023134-y665agnh 595 2 adverse adverse JJ cord-023134-y665agnh 595 3 effects effect NNS cord-023134-y665agnh 595 4 occurred occur VBD cord-023134-y665agnh 595 5 in in IN cord-023134-y665agnh 595 6 10/16 10/16 CD cord-023134-y665agnh 595 7 and and CC cord-023134-y665agnh 595 8 in in IN cord-023134-y665agnh 595 9 9/16 9/16 CD cord-023134-y665agnh 595 10 of of IN cord-023134-y665agnh 595 11 the the DT cord-023134-y665agnh 595 12 dogs dog NNS cord-023134-y665agnh 595 13 treated treat VBN cord-023134-y665agnh 595 14 with with IN cord-023134-y665agnh 595 15 SID SID NNP cord-023134-y665agnh 595 16 and and CC cord-023134-y665agnh 595 17 BID BID NNP cord-023134-y665agnh 595 18 trilostane trilostane NNP cord-023134-y665agnh 595 19 , , , cord-023134-y665agnh 595 20 respectively respectively RB cord-023134-y665agnh 595 21 . . . cord-023134-y665agnh 596 1 Based base VBN cord-023134-y665agnh 596 2 on on IN cord-023134-y665agnh 596 3 this this DT cord-023134-y665agnh 596 4 study study NN cord-023134-y665agnh 596 5 , , , cord-023134-y665agnh 596 6 we -PRON- PRP cord-023134-y665agnh 596 7 conclude conclude VBP cord-023134-y665agnh 596 8 that that IN cord-023134-y665agnh 596 9 the the DT cord-023134-y665agnh 596 10 results result NNS cord-023134-y665agnh 596 11 of of IN cord-023134-y665agnh 596 12 ACTH ACTH NNP cord-023134-y665agnh 596 13 stimulation stimulation NN cord-023134-y665agnh 596 14 test test NN cord-023134-y665agnh 596 15 and and CC cord-023134-y665agnh 596 16 UCCR UCCR NNP cord-023134-y665agnh 596 17 in in IN cord-023134-y665agnh 596 18 dogs dog NNS cord-023134-y665agnh 596 19 with with IN cord-023134-y665agnh 596 20 PDH PDH NNP cord-023134-y665agnh 596 21 treated treat VBN cord-023134-y665agnh 596 22 with with IN cord-023134-y665agnh 596 23 both both DT cord-023134-y665agnh 596 24 protocols protocol NNS cord-023134-y665agnh 596 25 are be VBP cord-023134-y665agnh 596 26 similar similar JJ cord-023134-y665agnh 596 27 at at IN cord-023134-y665agnh 596 28 most most JJS cord-023134-y665agnh 596 29 re re NN cord-023134-y665agnh 596 30 - - NN cord-023134-y665agnh 596 31 evaluation evaluation NN cord-023134-y665agnh 596 32 times time NNS cord-023134-y665agnh 596 33 . . . cord-023134-y665agnh 597 1 However however RB cord-023134-y665agnh 597 2 , , , cord-023134-y665agnh 597 3 clinical clinical JJ cord-023134-y665agnh 597 4 signs sign NNS cord-023134-y665agnh 597 5 resolved resolve VBN cord-023134-y665agnh 597 6 in in IN cord-023134-y665agnh 597 7 a a DT cord-023134-y665agnh 597 8 greater great JJR cord-023134-y665agnh 597 9 proportion proportion NN cord-023134-y665agnh 597 10 of of IN cord-023134-y665agnh 597 11 dogs dog NNS cord-023134-y665agnh 597 12 receiving receive VBG cord-023134-y665agnh 597 13 trilostane trilostane NNP cord-023134-y665agnh 597 14 BID BID NNP cord-023134-y665agnh 597 15 . . . cord-023134-y665agnh 598 1 Using use VBG cord-023134-y665agnh 598 2 trilostane trilostane NNP cord-023134-y665agnh 598 3 twice twice NNP cord-023134-y665agnh 598 4 daily daily RB cord-023134-y665agnh 598 5 will will MD cord-023134-y665agnh 598 6 help help VB cord-023134-y665agnh 598 7 to to TO cord-023134-y665agnh 598 8 reduce reduce VB cord-023134-y665agnh 598 9 the the DT cord-023134-y665agnh 598 10 number number NN cord-023134-y665agnh 598 11 of of IN cord-023134-y665agnh 598 12 dogs dog NNS cord-023134-y665agnh 598 13 that that WDT cord-023134-y665agnh 598 14 do do VBP cord-023134-y665agnh 598 15 not not RB cord-023134-y665agnh 598 16 have have VB cord-023134-y665agnh 598 17 a a DT cord-023134-y665agnh 598 18 good good JJ cord-023134-y665agnh 598 19 clinical clinical JJ cord-023134-y665agnh 598 20 response response NN cord-023134-y665agnh 598 21 . . . cord-023134-y665agnh 599 1 The the DT cord-023134-y665agnh 599 2 effectiveness effectiveness NN cord-023134-y665agnh 599 3 of of IN cord-023134-y665agnh 599 4 trilostane trilostane NNP cord-023134-y665agnh 599 5 therapy therapy NNP cord-023134-y665agnh 599 6 is be VBZ cord-023134-y665agnh 599 7 monitored monitor VBN cord-023134-y665agnh 599 8 by by IN cord-023134-y665agnh 599 9 regular regular JJ cord-023134-y665agnh 599 10 ACTH ACTH NNP cord-023134-y665agnh 599 11 stimulation stimulation NN cord-023134-y665agnh 599 12 , , , cord-023134-y665agnh 599 13 which which WDT cord-023134-y665agnh 599 14 is be VBZ cord-023134-y665agnh 599 15 time time NN cord-023134-y665agnh 599 16 - - HYPH cord-023134-y665agnh 599 17 consuming consume VBG cord-023134-y665agnh 599 18 and and CC cord-023134-y665agnh 599 19 expensive expensive JJ cord-023134-y665agnh 599 20 . . . cord-023134-y665agnh 600 1 Therefore therefore RB cord-023134-y665agnh 600 2 , , , cord-023134-y665agnh 600 3 a a DT cord-023134-y665agnh 600 4 monitoring monitoring NN cord-023134-y665agnh 600 5 system system NN cord-023134-y665agnh 600 6 without without IN cord-023134-y665agnh 600 7 a a DT cord-023134-y665agnh 600 8 stimulation stimulation NN cord-023134-y665agnh 600 9 protocol protocol NN cord-023134-y665agnh 600 10 and and CC cord-023134-y665agnh 600 11 with with IN cord-023134-y665agnh 600 12 less less JJR cord-023134-y665agnh 600 13 client client NN cord-023134-y665agnh 600 14 expense expense NN cord-023134-y665agnh 600 15 would would MD cord-023134-y665agnh 600 16 be be VB cord-023134-y665agnh 600 17 preferable preferable JJ cord-023134-y665agnh 600 18 . . . cord-023134-y665agnh 601 1 The the DT cord-023134-y665agnh 601 2 aim aim NN cord-023134-y665agnh 601 3 of of IN cord-023134-y665agnh 601 4 our -PRON- PRP$ cord-023134-y665agnh 601 5 study study NN cord-023134-y665agnh 601 6 was be VBD cord-023134-y665agnh 601 7 twofold twofold JJ cord-023134-y665agnh 601 8 : : : cord-023134-y665agnh 601 9 firstly firstly RB cord-023134-y665agnh 601 10 , , , cord-023134-y665agnh 601 11 to to TO cord-023134-y665agnh 601 12 evaluate evaluate VB cord-023134-y665agnh 601 13 , , , cord-023134-y665agnh 601 14 if if IN cord-023134-y665agnh 601 15 baseline baseline JJ cord-023134-y665agnh 601 16 cortisol cortisol NN cord-023134-y665agnh 601 17 , , , cord-023134-y665agnh 601 18 endogenous endogenous JJ cord-023134-y665agnh 601 19 ACTH ACTH NNP cord-023134-y665agnh 601 20 ( ( -LRB- cord-023134-y665agnh 601 21 cACTH cacth NN cord-023134-y665agnh 601 22 ) ) -RRB- cord-023134-y665agnh 601 23 or or CC cord-023134-y665agnh 601 24 the the DT cord-023134-y665agnh 601 25 baseline baseline JJ cord-023134-y665agnh 601 26 cortisol cortisol NN cord-023134-y665agnh 601 27 to to IN cord-023134-y665agnh 601 28 ACTH ACTH NNP cord-023134-y665agnh 601 29 ratio ratio NN cord-023134-y665agnh 602 1 ( ( -LRB- cord-023134-y665agnh 602 2 cortisol cortisol NN cord-023134-y665agnh 602 3 / / SYM cord-023134-y665agnh 602 4 ACTH ACTH NNP cord-023134-y665agnh 602 5 ratio ratio NN cord-023134-y665agnh 602 6 ) ) -RRB- cord-023134-y665agnh 602 7 could could MD cord-023134-y665agnh 602 8 replace replace VB cord-023134-y665agnh 602 9 the the DT cord-023134-y665agnh 602 10 ACTH ACTH NNP cord-023134-y665agnh 602 11 stimulation stimulation NN cord-023134-y665agnh 602 12 test test NN cord-023134-y665agnh 602 13 ; ; : cord-023134-y665agnh 602 14 secondly secondly RB cord-023134-y665agnh 602 15 , , , cord-023134-y665agnh 602 16 to to TO cord-023134-y665agnh 602 17 evaluate evaluate VB cord-023134-y665agnh 602 18 , , , cord-023134-y665agnh 602 19 if if IN cord-023134-y665agnh 602 20 baseline baseline JJ cord-023134-y665agnh 602 21 cortisol cortisol NN cord-023134-y665agnh 602 22 provides provide VBZ cord-023134-y665agnh 602 23 additional additional JJ cord-023134-y665agnh 602 24 information information NN cord-023134-y665agnh 602 25 than than IN cord-023134-y665agnh 602 26 post post JJ cord-023134-y665agnh 602 27 - - JJ cord-023134-y665agnh 602 28 ACTH acth JJ cord-023134-y665agnh 602 29 cortisol cortisol NN cord-023134-y665agnh 602 30 alone alone RB cord-023134-y665agnh 602 31 or or CC cord-023134-y665agnh 602 32 if if IN cord-023134-y665agnh 602 33 its -PRON- PRP$ cord-023134-y665agnh 602 34 measurement measurement NN cord-023134-y665agnh 602 35 could could MD cord-023134-y665agnh 602 36 be be VB cord-023134-y665agnh 602 37 abandoned abandon VBN cord-023134-y665agnh 602 38 . . . cord-023134-y665agnh 603 1 Forty forty CD cord-023134-y665agnh 603 2 - - HYPH cord-023134-y665agnh 603 3 one one CD cord-023134-y665agnh 603 4 trilostane trilostane NN cord-023134-y665agnh 603 5 - - HYPH cord-023134-y665agnh 603 6 treated treat VBN cord-023134-y665agnh 603 7 dogs dog NNS cord-023134-y665agnh 603 8 with with IN cord-023134-y665agnh 603 9 PDH PDH NNP cord-023134-y665agnh 603 10 diagnosed diagnose VBN cord-023134-y665agnh 603 11 between between IN cord-023134-y665agnh 603 12 April April NNP cord-023134-y665agnh 603 13 2006 2006 CD cord-023134-y665agnh 603 14 and and CC cord-023134-y665agnh 603 15 December December NNP cord-023134-y665agnh 603 16 2011 2011 CD cord-023134-y665agnh 603 17 were be VBD cord-023134-y665agnh 603 18 included include VBN cord-023134-y665agnh 603 19 in in IN cord-023134-y665agnh 603 20 the the DT cord-023134-y665agnh 603 21 study study NN cord-023134-y665agnh 603 22 . . . cord-023134-y665agnh 604 1 A a DT cord-023134-y665agnh 604 2 total total NN cord-023134-y665agnh 604 3 of of IN cord-023134-y665agnh 604 4 148 148 CD cord-023134-y665agnh 604 5 ACTH ACTH NNP cord-023134-y665agnh 604 6 stimulation stimulation NN cord-023134-y665agnh 604 7 tests test NNS cord-023134-y665agnh 604 8 with with IN cord-023134-y665agnh 604 9 baseline baseline NN cord-023134-y665agnh 604 10 , , , cord-023134-y665agnh 604 11 post post JJ cord-023134-y665agnh 604 12 - - JJ cord-023134-y665agnh 604 13 ACTH ACTH NNP cord-023134-y665agnh 604 14 and and CC cord-023134-y665agnh 604 15 delta delta NNP cord-023134-y665agnh 604 16 cortisol cortisol NNP cord-023134-y665agnh 604 17 ( ( -LRB- cord-023134-y665agnh 604 18 post post JJ cord-023134-y665agnh 604 19 - - JJ cord-023134-y665agnh 604 20 ACTH acth JJ cord-023134-y665agnh 604 21 cortisol cortisol NN cord-023134-y665agnh 604 22 minus minus IN cord-023134-y665agnh 604 23 baseline baseline JJ cord-023134-y665agnh 604 24 cortisol cortisol NNP cord-023134-y665agnh 604 25 ) ) -RRB- cord-023134-y665agnh 604 26 and and CC cord-023134-y665agnh 604 27 75 75 CD cord-023134-y665agnh 604 28 cACTH cacth NN cord-023134-y665agnh 604 29 results result NNS cord-023134-y665agnh 604 30 and and CC cord-023134-y665agnh 604 31 cortisol cortisol NN cord-023134-y665agnh 604 32 / / SYM cord-023134-y665agnh 604 33 ACTH ACTH NNP cord-023134-y665agnh 604 34 ratios ratio NNS cord-023134-y665agnh 604 35 were be VBD cord-023134-y665agnh 604 36 analyzed analyze VBN cord-023134-y665agnh 604 37 . . . cord-023134-y665agnh 605 1 Control control NN cord-023134-y665agnh 605 2 of of IN cord-023134-y665agnh 605 3 adrenal adrenal JJ cord-023134-y665agnh 605 4 gland gland NN cord-023134-y665agnh 605 5 function function NN cord-023134-y665agnh 605 6 was be VBD cord-023134-y665agnh 605 7 classified classify VBN cord-023134-y665agnh 605 8 according accord VBG cord-023134-y665agnh 605 9 to to IN cord-023134-y665agnh 605 10 the the DT cord-023134-y665agnh 605 11 target target NN cord-023134-y665agnh 605 12 range range NN cord-023134-y665agnh 605 13 of of IN cord-023134-y665agnh 605 14 post post JJ cord-023134-y665agnh 605 15 - - JJ cord-023134-y665agnh 605 16 ACTH acth JJ cord-023134-y665agnh 605 17 cortisol cortisol NN cord-023134-y665agnh 605 18 concentration concentration NN cord-023134-y665agnh 605 19 as as IN cord-023134-y665agnh 605 20 : : : cord-023134-y665agnh 605 21 excessive excessive JJ cord-023134-y665agnh 605 22 ( ( -LRB- cord-023134-y665agnh 605 23 < < NNP cord-023134-y665agnh 605 24 41 41 CD cord-023134-y665agnh 605 25 nmol nmol NNP cord-023134-y665agnh 605 26 / / SYM cord-023134-y665agnh 605 27 L l NN cord-023134-y665agnh 605 28 ; ; : cord-023134-y665agnh 605 29 group group NN cord-023134-y665agnh 605 30 1 1 CD cord-023134-y665agnh 605 31 ) ) -RRB- cord-023134-y665agnh 605 32 , , , cord-023134-y665agnh 605 33 optimal optimal JJ cord-023134-y665agnh 605 34 ( ( -LRB- cord-023134-y665agnh 605 35 41 41 CD cord-023134-y665agnh 605 36 - - SYM cord-023134-y665agnh 605 37 149 149 CD cord-023134-y665agnh 605 38 nmol nmol JJ cord-023134-y665agnh 605 39 / / SYM cord-023134-y665agnh 605 40 L l NN cord-023134-y665agnh 605 41 ; ; : cord-023134-y665agnh 605 42 group group NN cord-023134-y665agnh 605 43 2 2 CD cord-023134-y665agnh 605 44 ) ) -RRB- cord-023134-y665agnh 605 45 , , , cord-023134-y665agnh 605 46 or or CC cord-023134-y665agnh 605 47 inadequate inadequate JJ cord-023134-y665agnh 605 48 ( ( -LRB- cord-023134-y665agnh 605 49 > > NFP cord-023134-y665agnh 605 50 149 149 CD cord-023134-y665agnh 605 51 nmol nmol JJ cord-023134-y665agnh 605 52 / / SYM cord-023134-y665agnh 605 53 L l NN cord-023134-y665agnh 605 54 ; ; : cord-023134-y665agnh 605 55 group group NN cord-023134-y665agnh 605 56 3 3 CD cord-023134-y665agnh 605 57 ) ) -RRB- cord-023134-y665agnh 605 58 . . . cord-023134-y665agnh 606 1 In in IN cord-023134-y665agnh 606 2 a a DT cord-023134-y665agnh 606 3 second second JJ cord-023134-y665agnh 606 4 step step NN cord-023134-y665agnh 606 5 , , , cord-023134-y665agnh 606 6 control control NN cord-023134-y665agnh 606 7 of of IN cord-023134-y665agnh 606 8 adrenal adrenal JJ cord-023134-y665agnh 606 9 gland gland NN cord-023134-y665agnh 606 10 function function NN cord-023134-y665agnh 606 11 was be VBD cord-023134-y665agnh 606 12 reclassified reclassify VBN cord-023134-y665agnh 606 13 according accord VBG cord-023134-y665agnh 606 14 to to IN cord-023134-y665agnh 606 15 baseline baseline JJ cord-023134-y665agnh 606 16 cortisol cortisol NN cord-023134-y665agnh 606 17 values value NNS cord-023134-y665agnh 606 18 only only RB cord-023134-y665agnh 606 19 and and CC cord-023134-y665agnh 606 20 the the DT cord-023134-y665agnh 606 21 new new JJ cord-023134-y665agnh 606 22 classification classification NN cord-023134-y665agnh 606 23 was be VBD cord-023134-y665agnh 606 24 compared compare VBN cord-023134-y665agnh 606 25 with with IN cord-023134-y665agnh 606 26 the the DT cord-023134-y665agnh 606 27 original original JJ cord-023134-y665agnh 606 28 one one CD cord-023134-y665agnh 606 29 . . . cord-023134-y665agnh 607 1 There there EX cord-023134-y665agnh 607 2 was be VBD cord-023134-y665agnh 607 3 a a DT cord-023134-y665agnh 607 4 significant significant JJ cord-023134-y665agnh 607 5 correlation correlation NN cord-023134-y665agnh 607 6 between between IN cord-023134-y665agnh 607 7 baseline baseline JJ cord-023134-y665agnh 607 8 cortisol cortisol NN cord-023134-y665agnh 607 9 and and CC cord-023134-y665agnh 607 10 post post JJ cord-023134-y665agnh 607 11 - - JJ cord-023134-y665agnh 607 12 ACTH acth JJ cord-023134-y665agnh 607 13 cortisol cortisol NN cord-023134-y665agnh 607 14 and and CC cord-023134-y665agnh 607 15 a a DT cord-023134-y665agnh 607 16 significant significant JJ cord-023134-y665agnh 607 17 difference difference NN cord-023134-y665agnh 607 18 of of IN cord-023134-y665agnh 607 19 baseline baseline JJ cord-023134-y665agnh 607 20 cortisol cortisol NN cord-023134-y665agnh 607 21 between between IN cord-023134-y665agnh 607 22 the the DT cord-023134-y665agnh 607 23 groups group NNS cord-023134-y665agnh 607 24 , , , cord-023134-y665agnh 607 25 however however RB cord-023134-y665agnh 607 26 , , , cord-023134-y665agnh 607 27 with with IN cord-023134-y665agnh 607 28 a a DT cord-023134-y665agnh 607 29 large large JJ cord-023134-y665agnh 607 30 overlap overlap NN cord-023134-y665agnh 607 31 . . . cord-023134-y665agnh 608 1 Reclassification reclassification NN cord-023134-y665agnh 608 2 of of IN cord-023134-y665agnh 608 3 the the DT cord-023134-y665agnh 608 4 adrenal adrenal JJ cord-023134-y665agnh 608 5 gland gland NN cord-023134-y665agnh 608 6 function function NN cord-023134-y665agnh 608 7 on on IN cord-023134-y665agnh 608 8 the the DT cord-023134-y665agnh 608 9 basis basis NN cord-023134-y665agnh 608 10 of of IN cord-023134-y665agnh 608 11 baseline baseline JJ cord-023134-y665agnh 608 12 cortisol cortisol NN cord-023134-y665agnh 608 13 revealed reveal VBD cord-023134-y665agnh 608 14 a a DT cord-023134-y665agnh 608 15 misclassification misclassification NN cord-023134-y665agnh 608 16 in in IN cord-023134-y665agnh 608 17 53/ 53/ CD cord-023134-y665agnh 608 18 148 148 CD cord-023134-y665agnh 608 19 ( ( -LRB- cord-023134-y665agnh 608 20 36 36 CD cord-023134-y665agnh 608 21 % % NN cord-023134-y665agnh 608 22 ) ) -RRB- cord-023134-y665agnh 608 23 tests test NNS cord-023134-y665agnh 608 24 . . . cord-023134-y665agnh 609 1 Endogenous endogenous JJ cord-023134-y665agnh 609 2 ACTH ACTH NNP cord-023134-y665agnh 609 3 did do VBD cord-023134-y665agnh 609 4 not not RB cord-023134-y665agnh 609 5 correlate correlate VB cord-023134-y665agnh 609 6 with with IN cord-023134-y665agnh 609 7 baseline baseline JJ cord-023134-y665agnh 609 8 or or CC cord-023134-y665agnh 609 9 post post JJ cord-023134-y665agnh 609 10 - - JJ cord-023134-y665agnh 609 11 ACTH acth JJ cord-023134-y665agnh 609 12 cortisol cortisol NN cord-023134-y665agnh 609 13 and and CC cord-023134-y665agnh 609 14 did do VBD cord-023134-y665agnh 609 15 not not RB cord-023134-y665agnh 609 16 differ differ VB cord-023134-y665agnh 609 17 between between IN cord-023134-y665agnh 609 18 the the DT cord-023134-y665agnh 609 19 groups group NNS cord-023134-y665agnh 609 20 . . . cord-023134-y665agnh 610 1 The the DT cord-023134-y665agnh 610 2 baseline baseline JJ cord-023134-y665agnh 610 3 cortisol cortisol NN cord-023134-y665agnh 610 4 : : : cord-023134-y665agnh 610 5 ACTH ACTH NNP cord-023134-y665agnh 610 6 ratio ratio NN cord-023134-y665agnh 610 7 differed differ VBD cord-023134-y665agnh 610 8 significantly significantly RB cord-023134-y665agnh 610 9 between between IN cord-023134-y665agnh 610 10 group group NN cord-023134-y665agnh 610 11 1 1 CD cord-023134-y665agnh 610 12 and and CC cord-023134-y665agnh 610 13 3 3 CD cord-023134-y665agnh 610 14 and and CC cord-023134-y665agnh 610 15 between between IN cord-023134-y665agnh 610 16 group group NN cord-023134-y665agnh 610 17 2 2 CD cord-023134-y665agnh 610 18 and and CC cord-023134-y665agnh 610 19 3 3 CD cord-023134-y665agnh 610 20 , , , cord-023134-y665agnh 610 21 but but CC cord-023134-y665agnh 610 22 again again RB cord-023134-y665agnh 610 23 with with IN cord-023134-y665agnh 610 24 a a DT cord-023134-y665agnh 610 25 large large JJ cord-023134-y665agnh 610 26 overlap overlap NN cord-023134-y665agnh 610 27 . . . cord-023134-y665agnh 611 1 To to TO cord-023134-y665agnh 611 2 determine determine VB cord-023134-y665agnh 611 3 if if IN cord-023134-y665agnh 611 4 measurement measurement NN cord-023134-y665agnh 611 5 of of IN cord-023134-y665agnh 611 6 baseline baseline JJ cord-023134-y665agnh 611 7 cortisol cortisol NN cord-023134-y665agnh 611 8 gives give VBZ cord-023134-y665agnh 611 9 additional additional JJ cord-023134-y665agnh 611 10 information information NN cord-023134-y665agnh 611 11 than than IN cord-023134-y665agnh 611 12 post post JJ cord-023134-y665agnh 611 13 - - JJ cord-023134-y665agnh 611 14 ACTH acth JJ cord-023134-y665agnh 611 15 cortisol cortisol NN cord-023134-y665agnh 611 16 alone alone RB cord-023134-y665agnh 611 17 , , , cord-023134-y665agnh 611 18 the the DT cord-023134-y665agnh 611 19 delta delta NN cord-023134-y665agnh 611 20 cortisol cortisol NN cord-023134-y665agnh 611 21 values value NNS cord-023134-y665agnh 611 22 were be VBD cord-023134-y665agnh 611 23 analysed analyse VBN cord-023134-y665agnh 611 24 . . . cord-023134-y665agnh 612 1 Delta Delta NNP cord-023134-y665agnh 612 2 cortisol cortisol NN cord-023134-y665agnh 612 3 correlated correlate VBD cord-023134-y665agnh 612 4 significantly significantly RB cord-023134-y665agnh 612 5 with with IN cord-023134-y665agnh 612 6 post post JJ cord-023134-y665agnh 612 7 - - JJ cord-023134-y665agnh 612 8 ACTH acth JJ cord-023134-y665agnh 612 9 cortisol cortisol NN cord-023134-y665agnh 612 10 but but CC cord-023134-y665agnh 612 11 not not RB cord-023134-y665agnh 612 12 with with IN cord-023134-y665agnh 612 13 baseline baseline JJ cord-023134-y665agnh 612 14 cortisol cortisol NN cord-023134-y665agnh 612 15 and and CC cord-023134-y665agnh 612 16 differed differ VBD cord-023134-y665agnh 612 17 significantly significantly RB cord-023134-y665agnh 612 18 between between IN cord-023134-y665agnh 612 19 the the DT cord-023134-y665agnh 612 20 groups group NNS cord-023134-y665agnh 612 21 , , , cord-023134-y665agnh 612 22 the the DT cord-023134-y665agnh 612 23 overlap overlap NN cord-023134-y665agnh 612 24 however however RB cord-023134-y665agnh 612 25 was be VBD cord-023134-y665agnh 612 26 large large JJ cord-023134-y665agnh 612 27 . . . cord-023134-y665agnh 613 1 The the DT cord-023134-y665agnh 613 2 large large JJ cord-023134-y665agnh 613 3 overlap overlap NN cord-023134-y665agnh 613 4 using use VBG cord-023134-y665agnh 613 5 only only RB cord-023134-y665agnh 613 6 single single JJ cord-023134-y665agnh 613 7 values value NNS cord-023134-y665agnh 613 8 without without IN cord-023134-y665agnh 613 9 taking take VBG cord-023134-y665agnh 613 10 post post JJ cord-023134-y665agnh 613 11 - - JJ cord-023134-y665agnh 613 12 ACTH acth JJ cord-023134-y665agnh 613 13 cortisol cortisol NN cord-023134-y665agnh 613 14 into into IN cord-023134-y665agnh 613 15 consideration consideration NN cord-023134-y665agnh 613 16 leads lead VBZ cord-023134-y665agnh 613 17 to to IN cord-023134-y665agnh 613 18 an an DT cord-023134-y665agnh 613 19 unacceptably unacceptably RB cord-023134-y665agnh 613 20 low low JJ cord-023134-y665agnh 613 21 correct correct JJ cord-023134-y665agnh 613 22 differentiation differentiation NN cord-023134-y665agnh 613 23 of of IN cord-023134-y665agnh 613 24 control control NN cord-023134-y665agnh 613 25 of of IN cord-023134-y665agnh 613 26 adrenal adrenal JJ cord-023134-y665agnh 613 27 gland gland NN cord-023134-y665agnh 613 28 function function NN cord-023134-y665agnh 613 29 . . . cord-023134-y665agnh 614 1 Therefore therefore RB cord-023134-y665agnh 614 2 , , , cord-023134-y665agnh 614 3 the the DT cord-023134-y665agnh 614 4 ACTH ACTH NNP cord-023134-y665agnh 614 5 stimulation stimulation NN cord-023134-y665agnh 614 6 test test NN cord-023134-y665agnh 614 7 and and CC cord-023134-y665agnh 614 8 determination determination NN cord-023134-y665agnh 614 9 of of IN cord-023134-y665agnh 614 10 post post JJ cord-023134-y665agnh 614 11 - - JJ cord-023134-y665agnh 614 12 ACTH acth JJ cord-023134-y665agnh 614 13 cortisol cortisol NN cord-023134-y665agnh 614 14 can can MD cord-023134-y665agnh 614 15 not not RB cord-023134-y665agnh 614 16 be be VB cord-023134-y665agnh 614 17 replaced replace VBN cord-023134-y665agnh 614 18 by by IN cord-023134-y665agnh 614 19 baseline baseline JJ cord-023134-y665agnh 614 20 cortisol cortisol NN cord-023134-y665agnh 614 21 , , , cord-023134-y665agnh 614 22 endogenous endogenous JJ cord-023134-y665agnh 614 23 ACTH ACTH NNP cord-023134-y665agnh 614 24 or or CC cord-023134-y665agnh 614 25 the the DT cord-023134-y665agnh 614 26 cortisol cortisol NN cord-023134-y665agnh 614 27 / / SYM cord-023134-y665agnh 614 28 ACTH ACTH NNP cord-023134-y665agnh 614 29 ratio ratio NN cord-023134-y665agnh 614 30 . . . cord-023134-y665agnh 615 1 However however RB cord-023134-y665agnh 615 2 , , , cord-023134-y665agnh 615 3 as as IN cord-023134-y665agnh 615 4 baseline baseline JJ cord-023134-y665agnh 615 5 cortisol cortisol NN cord-023134-y665agnh 615 6 concentration concentration NN cord-023134-y665agnh 615 7 does do VBZ cord-023134-y665agnh 615 8 not not RB cord-023134-y665agnh 615 9 give give VB cord-023134-y665agnh 615 10 additional additional JJ cord-023134-y665agnh 615 11 information information NN cord-023134-y665agnh 615 12 than than IN cord-023134-y665agnh 615 13 post post JJ cord-023134-y665agnh 615 14 - - JJ cord-023134-y665agnh 615 15 ACTH acth JJ cord-023134-y665agnh 615 16 cortisol cortisol NN cord-023134-y665agnh 615 17 alone alone RB cord-023134-y665agnh 615 18 , , , cord-023134-y665agnh 615 19 its -PRON- PRP$ cord-023134-y665agnh 615 20 determination determination NN cord-023134-y665agnh 615 21 can can MD cord-023134-y665agnh 615 22 be be VB cord-023134-y665agnh 615 23 abandoned abandon VBN cord-023134-y665agnh 615 24 . . . cord-023134-y665agnh 616 1 In in IN cord-023134-y665agnh 616 2 humans human NNS cord-023134-y665agnh 616 3 , , , cord-023134-y665agnh 616 4 recombinant recombinant JJ cord-023134-y665agnh 616 5 human human NN cord-023134-y665agnh 616 6 thyrotropin thyrotropin NN cord-023134-y665agnh 616 7 ( ( -LRB- cord-023134-y665agnh 616 8 rhTSH rhtsh NN cord-023134-y665agnh 616 9 ) ) -RRB- cord-023134-y665agnh 616 10 enhances enhance VBZ cord-023134-y665agnh 616 11 radioactive radioactive JJ cord-023134-y665agnh 616 12 iodine iodine NN cord-023134-y665agnh 616 13 uptake uptake NN cord-023134-y665agnh 616 14 ( ( -LRB- cord-023134-y665agnh 616 15 RAIU RAIU NNP cord-023134-y665agnh 616 16 ) ) -RRB- cord-023134-y665agnh 616 17 in in IN cord-023134-y665agnh 616 18 patients patient NNS cord-023134-y665agnh 616 19 with with IN cord-023134-y665agnh 616 20 differentiated differentiated JJ cord-023134-y665agnh 616 21 thyroid thyroid JJ cord-023134-y665agnh 616 22 cancer cancer NN cord-023134-y665agnh 616 23 . . . cord-023134-y665agnh 617 1 This this DT cord-023134-y665agnh 617 2 property property NN cord-023134-y665agnh 617 3 is be VBZ cord-023134-y665agnh 617 4 particularly particularly RB cord-023134-y665agnh 617 5 interesting interesting JJ cord-023134-y665agnh 617 6 in in IN cord-023134-y665agnh 617 7 dogs dog NNS cord-023134-y665agnh 617 8 because because IN cord-023134-y665agnh 617 9 high high JJ cord-023134-y665agnh 617 10 doses dose NNS cord-023134-y665agnh 617 11 of of IN cord-023134-y665agnh 617 12 radioiodine-131 radioiodine-131 NNP cord-023134-y665agnh 617 13 ( ( -LRB- cord-023134-y665agnh 617 14 131 131 CD cord-023134-y665agnh 617 15 I i NN cord-023134-y665agnh 617 16 ) ) -RRB- cord-023134-y665agnh 617 17 are be VBP cord-023134-y665agnh 617 18 used use VBN cord-023134-y665agnh 617 19 for for IN cord-023134-y665agnh 617 20 the the DT cord-023134-y665agnh 617 21 treatment treatment NN cord-023134-y665agnh 617 22 of of IN cord-023134-y665agnh 617 23 this this DT cord-023134-y665agnh 617 24 disease disease NN cord-023134-y665agnh 617 25 . . . cord-023134-y665agnh 618 1 No no DT cord-023134-y665agnh 618 2 studies study NNS cord-023134-y665agnh 618 3 have have VBP cord-023134-y665agnh 618 4 been be VBN cord-023134-y665agnh 618 5 performed perform VBN cord-023134-y665agnh 618 6 in in IN cord-023134-y665agnh 618 7 veterinary veterinary JJ cord-023134-y665agnh 618 8 medicine medicine NN cord-023134-y665agnh 618 9 to to TO cord-023134-y665agnh 618 10 optimize optimize VB cord-023134-y665agnh 618 11 131 131 CD cord-023134-y665agnh 618 12 I I NNP cord-023134-y665agnh 618 13 treatment treatment NN cord-023134-y665agnh 618 14 of of IN cord-023134-y665agnh 618 15 thyroid thyroid NN cord-023134-y665agnh 618 16 cancer cancer NN cord-023134-y665agnh 618 17 . . . cord-023134-y665agnh 619 1 The the DT cord-023134-y665agnh 619 2 aim aim NN cord-023134-y665agnh 619 3 of of IN cord-023134-y665agnh 619 4 this this DT cord-023134-y665agnh 619 5 study study NN cord-023134-y665agnh 619 6 was be VBD cord-023134-y665agnh 619 7 to to TO cord-023134-y665agnh 619 8 evaluate evaluate VB cord-023134-y665agnh 619 9 the the DT cord-023134-y665agnh 619 10 effect effect NN cord-023134-y665agnh 619 11 of of IN cord-023134-y665agnh 619 12 rhTSH rhtsh NN cord-023134-y665agnh 619 13 on on IN cord-023134-y665agnh 619 14 the the DT cord-023134-y665agnh 619 15 uptake uptake NN cord-023134-y665agnh 619 16 of of IN cord-023134-y665agnh 619 17 123 123 CD cord-023134-y665agnh 619 18 I i NN cord-023134-y665agnh 619 19 in in IN cord-023134-y665agnh 619 20 dogs dog NNS cord-023134-y665agnh 619 21 with with IN cord-023134-y665agnh 619 22 thyroid thyroid JJ cord-023134-y665agnh 619 23 tumors tumor NNS cord-023134-y665agnh 619 24 . . . cord-023134-y665agnh 620 1 Nine nine CD cord-023134-y665agnh 620 2 dogs dog NNS cord-023134-y665agnh 620 3 with with IN cord-023134-y665agnh 620 4 thyroid thyroid NN cord-023134-y665agnh 620 5 neoplasia neoplasia NNS cord-023134-y665agnh 620 6 were be VBD cord-023134-y665agnh 620 7 included include VBN cord-023134-y665agnh 620 8 in in IN cord-023134-y665agnh 620 9 this this DT cord-023134-y665agnh 620 10 prospective prospective JJ cord-023134-y665agnh 620 11 cross cross NN cord-023134-y665agnh 620 12 - - HYPH cord-023134-y665agnh 620 13 over over RP cord-023134-y665agnh 620 14 study study NN cord-023134-y665agnh 620 15 . . . cord-023134-y665agnh 621 1 Six six CD cord-023134-y665agnh 621 2 dogs dog NNS cord-023134-y665agnh 621 3 had have VBD cord-023134-y665agnh 621 4 unilateral unilateral JJ cord-023134-y665agnh 621 5 tumors tumor NNS cord-023134-y665agnh 621 6 , , , cord-023134-y665agnh 621 7 1 1 CD cord-023134-y665agnh 621 8 dog dog NN cord-023134-y665agnh 621 9 had have VBD cord-023134-y665agnh 621 10 bilateral bilateral JJ cord-023134-y665agnh 621 11 tumors tumor NNS cord-023134-y665agnh 621 12 and and CC cord-023134-y665agnh 621 13 2 2 CD cord-023134-y665agnh 621 14 dogs dog NNS cord-023134-y665agnh 621 15 had have VBD cord-023134-y665agnh 621 16 ectopic ectopic JJ cord-023134-y665agnh 621 17 tumors tumor NNS cord-023134-y665agnh 621 18 . . . cord-023134-y665agnh 622 1 Diagnosis diagnosis NN cord-023134-y665agnh 622 2 was be VBD cord-023134-y665agnh 622 3 based base VBN cord-023134-y665agnh 622 4 on on IN cord-023134-y665agnh 622 5 physical physical JJ cord-023134-y665agnh 622 6 examination examination NN cord-023134-y665agnh 622 7 , , , cord-023134-y665agnh 622 8 cytology cytology NN cord-023134-y665agnh 622 9 , , , cord-023134-y665agnh 622 10 cervical cervical JJ cord-023134-y665agnh 622 11 scintigraphy scintigraphy NN cord-023134-y665agnh 622 12 and and CC cord-023134-y665agnh 622 13 , , , cord-023134-y665agnh 622 14 when when WRB cord-023134-y665agnh 622 15 available available JJ cord-023134-y665agnh 622 16 , , , cord-023134-y665agnh 622 17 histopathology histopathology NN cord-023134-y665agnh 622 18 . . . cord-023134-y665agnh 623 1 In in IN cord-023134-y665agnh 623 2 6 6 CD cord-023134-y665agnh 623 3 dogs dog NNS cord-023134-y665agnh 623 4 123 123 CD cord-023134-y665agnh 623 5 I -PRON- PRP cord-023134-y665agnh 623 6 was be VBD cord-023134-y665agnh 623 7 administered administer VBN cord-023134-y665agnh 623 8 for for IN cord-023134-y665agnh 623 9 a a DT cord-023134-y665agnh 623 10 baseline baseline JJ cord-023134-y665agnh 623 11 RAIU RAIU NNP cord-023134-y665agnh 623 12 determination determination NN cord-023134-y665agnh 623 13 in in IN cord-023134-y665agnh 623 14 week week NN cord-023134-y665agnh 623 15 1 1 CD cord-023134-y665agnh 623 16 . . . cord-023134-y665agnh 624 1 In in IN cord-023134-y665agnh 624 2 week week NN cord-023134-y665agnh 624 3 2 2 CD cord-023134-y665agnh 624 4 ( ( -LRB- cord-023134-y665agnh 624 5 after after IN cord-023134-y665agnh 624 6 a a DT cord-023134-y665agnh 624 7 wash wash NN cord-023134-y665agnh 624 8 out out IN cord-023134-y665agnh 624 9 period period NN cord-023134-y665agnh 624 10 of of IN cord-023134-y665agnh 624 11 2 2 CD cord-023134-y665agnh 624 12 weeks week NNS cord-023134-y665agnh 624 13 ) ) -RRB- cord-023134-y665agnh 624 14 , , , cord-023134-y665agnh 624 15 these these DT cord-023134-y665agnh 624 16 dogs dog NNS cord-023134-y665agnh 624 17 received receive VBD cord-023134-y665agnh 624 18 rhTSH rhTSH NNP cord-023134-y665agnh 624 19 ( ( -LRB- cord-023134-y665agnh 624 20 100 100 CD cord-023134-y665agnh 624 21 lg lg NNP cord-023134-y665agnh 624 22 IV IV NNP cord-023134-y665agnh 624 23 ) ) -RRB- cord-023134-y665agnh 624 24 24h 24h NNS cord-023134-y665agnh 624 25 before before IN cord-023134-y665agnh 624 26 123 123 CD cord-023134-y665agnh 624 27 I i NN cord-023134-y665agnh 624 28 injection injection NN cord-023134-y665agnh 624 29 . . . cord-023134-y665agnh 625 1 In in IN cord-023134-y665agnh 625 2 3 3 CD cord-023134-y665agnh 625 3 patients patient NNS cord-023134-y665agnh 625 4 the the DT cord-023134-y665agnh 625 5 order order NN cord-023134-y665agnh 625 6 of of IN cord-023134-y665agnh 625 7 the the DT cord-023134-y665agnh 625 8 protocol protocol NN cord-023134-y665agnh 625 9 was be VBD cord-023134-y665agnh 625 10 reversed reverse VBN cord-023134-y665agnh 625 11 . . . cord-023134-y665agnh 626 1 For for IN cord-023134-y665agnh 626 2 each each DT cord-023134-y665agnh 626 3 scan scan NN cord-023134-y665agnh 626 4 , , , cord-023134-y665agnh 626 5 the the DT cord-023134-y665agnh 626 6 dogs dog NNS cord-023134-y665agnh 626 7 received receive VBD cord-023134-y665agnh 626 8 37 37 CD cord-023134-y665agnh 626 9 MBq MBq NNS cord-023134-y665agnh 626 10 ( ( -LRB- cord-023134-y665agnh 626 11 1mCi 1mci CD cord-023134-y665agnh 626 12 ) ) -RRB- cord-023134-y665agnh 626 13 of of IN cord-023134-y665agnh 626 14 123 123 CD cord-023134-y665agnh 626 15 I i NN cord-023134-y665agnh 626 16 IV IV NNP cord-023134-y665agnh 626 17 and and CC cord-023134-y665agnh 626 18 planar planar JJ cord-023134-y665agnh 626 19 scintigraphy scintigraphy NNP cord-023134-y665agnh 626 20 was be VBD cord-023134-y665agnh 626 21 performed perform VBN cord-023134-y665agnh 626 22 8h 8h NNP cord-023134-y665agnh 626 23 and and CC cord-023134-y665agnh 626 24 24h 24h NNS cord-023134-y665agnh 626 25 thereafter thereafter RB cord-023134-y665agnh 626 26 for for IN cord-023134-y665agnh 626 27 tumor tumor NN cord-023134-y665agnh 626 28 RAIU RAIU NNP cord-023134-y665agnh 626 29 calculation calculation NN cord-023134-y665agnh 626 30 . . . cord-023134-y665agnh 627 1 Blood blood NN cord-023134-y665agnh 627 2 samples sample NNS cord-023134-y665agnh 627 3 were be VBD cord-023134-y665agnh 627 4 taken take VBN cord-023134-y665agnh 627 5 at at IN cord-023134-y665agnh 627 6 baseline baseline NN cord-023134-y665agnh 627 7 and and CC cord-023134-y665agnh 627 8 at at IN cord-023134-y665agnh 627 9 6 6 CD cord-023134-y665agnh 627 10 , , , cord-023134-y665agnh 627 11 12 12 CD cord-023134-y665agnh 627 12 , , , cord-023134-y665agnh 627 13 24 24 CD cord-023134-y665agnh 627 14 and and CC cord-023134-y665agnh 627 15 48h 48h NNS cord-023134-y665agnh 627 16 after after IN cord-023134-y665agnh 627 17 rhTSH rhTSH NNP cord-023134-y665agnh 627 18 administration administration NNP cord-023134-y665agnh 627 19 for for IN cord-023134-y665agnh 627 20 measurement measurement NN cord-023134-y665agnh 627 21 of of IN cord-023134-y665agnh 627 22 serum serum NN cord-023134-y665agnh 627 23 total total JJ cord-023134-y665agnh 627 24 thyroxine thyroxine NN cord-023134-y665agnh 627 25 ( ( -LRB- cord-023134-y665agnh 627 26 TT4 TT4 NNP cord-023134-y665agnh 627 27 ) ) -RRB- cord-023134-y665agnh 627 28 and and CC cord-023134-y665agnh 627 29 serum serum NN cord-023134-y665agnh 627 30 thyrotropin thyrotropin NN cord-023134-y665agnh 627 31 ( ( -LRB- cord-023134-y665agnh 627 32 TSH tsh NN cord-023134-y665agnh 627 33 ) ) -RRB- cord-023134-y665agnh 628 1 concentrations.rhTSH concentrations.rhtsh NN cord-023134-y665agnh 628 2 caused cause VBD cord-023134-y665agnh 628 3 no no DT cord-023134-y665agnh 628 4 statistical statistical JJ cord-023134-y665agnh 628 5 significant significant JJ cord-023134-y665agnh 628 6 change change NN cord-023134-y665agnh 628 7 on on IN cord-023134-y665agnh 628 8 thyroid thyroid NN cord-023134-y665agnh 628 9 tumor tumor NN cord-023134-y665agnh 628 10 RAIU RAIU NNP cord-023134-y665agnh 628 11 at at IN cord-023134-y665agnh 628 12 8h 8h NNP cord-023134-y665agnh 628 13 ( ( -LRB- cord-023134-y665agnh 628 14 p=0.89 p=0.89 NNP cord-023134-y665agnh 628 15 ) ) -RRB- cord-023134-y665agnh 628 16 or or CC cord-023134-y665agnh 628 17 at at IN cord-023134-y665agnh 628 18 24h 24h NNS cord-023134-y665agnh 628 19 ( ( -LRB- cord-023134-y665agnh 628 20 p=0.98 p=0.98 NNP cord-023134-y665agnh 628 21 ) ) -RRB- cord-023134-y665agnh 628 22 . . . cord-023134-y665agnh 629 1 Despite despite IN cord-023134-y665agnh 629 2 the the DT cord-023134-y665agnh 629 3 lack lack NN cord-023134-y665agnh 629 4 of of IN cord-023134-y665agnh 629 5 overall overall JJ cord-023134-y665agnh 629 6 statistical statistical JJ cord-023134-y665agnh 629 7 significance significance NN cord-023134-y665agnh 629 8 , , , cord-023134-y665agnh 629 9 after after IN cord-023134-y665agnh 629 10 rhTSH rhTSH NNP cord-023134-y665agnh 629 11 administration administration NN cord-023134-y665agnh 629 12 the the DT cord-023134-y665agnh 629 13 8h 8h NNP cord-023134-y665agnh 629 14 RAIU RAIU NNP cord-023134-y665agnh 629 15 increased increase VBD cord-023134-y665agnh 629 16 in in IN cord-023134-y665agnh 629 17 5 5 CD cord-023134-y665agnh 629 18 tumors tumor NNS cord-023134-y665agnh 629 19 and and CC cord-023134-y665agnh 629 20 the the DT cord-023134-y665agnh 629 21 24h 24h NNS cord-023134-y665agnh 629 22 RAIU RAIU NNP cord-023134-y665agnh 629 23 increased increase VBD cord-023134-y665agnh 629 24 in in IN cord-023134-y665agnh 629 25 4 4 CD cord-023134-y665agnh 629 26 tumors tumor NNS cord-023134-y665agnh 629 27 . . . cord-023134-y665agnh 630 1 When when WRB cord-023134-y665agnh 630 2 an an DT cord-023134-y665agnh 630 3 increased increase VBN cord-023134-y665agnh 630 4 RAIU RAIU NNP cord-023134-y665agnh 630 5 was be VBD cord-023134-y665agnh 630 6 observed observe VBN cord-023134-y665agnh 630 7 , , , cord-023134-y665agnh 630 8 123 123 CD cord-023134-y665agnh 630 9 I -PRON- PRP cord-023134-y665agnh 630 10 uptake uptake VBP cord-023134-y665agnh 630 11 with with IN cord-023134-y665agnh 630 12 rhTSH rhtsh NN cord-023134-y665agnh 630 13 ranged range VBD cord-023134-y665agnh 630 14 1.2 1.2 CD cord-023134-y665agnh 630 15 to to IN cord-023134-y665agnh 630 16 3.8 3.8 CD cord-023134-y665agnh 630 17 times time NNS cord-023134-y665agnh 630 18 baseline baseline JJ cord-023134-y665agnh 630 19 uptake uptake NN cord-023134-y665agnh 630 20 . . . cord-023134-y665agnh 631 1 In in IN cord-023134-y665agnh 631 2 3 3 CD cord-023134-y665agnh 631 3 patients patient NNS cord-023134-y665agnh 631 4 , , , cord-023134-y665agnh 631 5 the the DT cord-023134-y665agnh 631 6 post post NN cord-023134-y665agnh 631 7 - - JJ cord-023134-y665agnh 631 8 rhTSH rhtsh JJ cord-023134-y665agnh 631 9 RAIU RAIU NNP cord-023134-y665agnh 631 10 more more RBR cord-023134-y665agnh 631 11 than than IN cord-023134-y665agnh 631 12 doubled double VBD cord-023134-y665agnh 631 13 compared compare VBN cord-023134-y665agnh 631 14 to to IN cord-023134-y665agnh 631 15 baseline baseline JJ cord-023134-y665agnh 631 16 RAIU RAIU NNP cord-023134-y665agnh 631 17 . . . cord-023134-y665agnh 632 1 The the DT cord-023134-y665agnh 632 2 RAIU RAIU NNP cord-023134-y665agnh 632 3 of of IN cord-023134-y665agnh 632 4 2 2 CD cord-023134-y665agnh 632 5 thoracic thoracic JJ cord-023134-y665agnh 632 6 metastases metastasis NNS cord-023134-y665agnh 632 7 from from IN cord-023134-y665agnh 632 8 2 2 CD cord-023134-y665agnh 632 9 patients patient NNS cord-023134-y665agnh 632 10 could could MD cord-023134-y665agnh 632 11 be be VB cord-023134-y665agnh 632 12 calculated calculate VBN cord-023134-y665agnh 632 13 . . . cord-023134-y665agnh 633 1 In in IN cord-023134-y665agnh 633 2 1 1 CD cord-023134-y665agnh 633 3 thoracic thoracic JJ cord-023134-y665agnh 633 4 metastasis metastasis NN cord-023134-y665agnh 633 5 the the DT cord-023134-y665agnh 633 6 RAIU RAIU NNP cord-023134-y665agnh 633 7 doubled double VBD cord-023134-y665agnh 633 8 after after IN cord-023134-y665agnh 633 9 rhTSH rhtsh NN cord-023134-y665agnh 633 10 ; ; : cord-023134-y665agnh 633 11 in in IN cord-023134-y665agnh 633 12 the the DT cord-023134-y665agnh 633 13 other other JJ cord-023134-y665agnh 633 14 the the DT cord-023134-y665agnh 633 15 RAIU RAIU NNP cord-023134-y665agnh 633 16 decreased decrease VBD cord-023134-y665agnh 633 17 after after IN cord-023134-y665agnh 633 18 rhTSH.In rhTSH.In NNP cord-023134-y665agnh 633 19 euthyroid euthyroid NNP cord-023134-y665agnh 633 20 patients patient NNS cord-023134-y665agnh 633 21 , , , cord-023134-y665agnh 633 22 rhTSH rhTSH NNP cord-023134-y665agnh 633 23 induced induce VBD cord-023134-y665agnh 633 24 a a DT cord-023134-y665agnh 633 25 significant significant JJ cord-023134-y665agnh 633 26 increase increase NN cord-023134-y665agnh 633 27 in in IN cord-023134-y665agnh 633 28 TT4 TT4 NNP cord-023134-y665agnh 633 29 concentrations concentration NNS cord-023134-y665agnh 633 30 ( ( -LRB- cord-023134-y665agnh 633 31 p=0.01 p=0.01 NNP cord-023134-y665agnh 633 32 ) ) -RRB- cord-023134-y665agnh 633 33 , , , cord-023134-y665agnh 633 34 confirming confirm VBG cord-023134-y665agnh 633 35 the the DT cord-023134-y665agnh 633 36 biological biological JJ cord-023134-y665agnh 633 37 activity activity NN cord-023134-y665agnh 633 38 of of IN cord-023134-y665agnh 633 39 rhTSH.This rhtsh.this DT cord-023134-y665agnh 633 40 study study NN cord-023134-y665agnh 634 1 suggests suggest VBZ cord-023134-y665agnh 634 2 that that IN cord-023134-y665agnh 634 3 IV IV NNP cord-023134-y665agnh 634 4 administration administration NN cord-023134-y665agnh 634 5 of of IN cord-023134-y665agnh 634 6 100 100 CD cord-023134-y665agnh 634 7 lg lg NNP cord-023134-y665agnh 634 8 rhTSH rhTSH NNP cord-023134-y665agnh 634 9 24h 24h NNP cord-023134-y665agnh 634 10 before before IN cord-023134-y665agnh 634 11 123 123 CD cord-023134-y665agnh 634 12 I -PRON- PRP cord-023134-y665agnh 634 13 has have VBZ cord-023134-y665agnh 634 14 an an DT cord-023134-y665agnh 634 15 inconsistent inconsistent JJ cord-023134-y665agnh 634 16 effect effect NN cord-023134-y665agnh 634 17 on on IN cord-023134-y665agnh 634 18 thyroid thyroid NN cord-023134-y665agnh 634 19 tumor tumor NN cord-023134-y665agnh 634 20 RAIU RAIU NNP cord-023134-y665agnh 634 21 , , , cord-023134-y665agnh 634 22 with with IN cord-023134-y665agnh 634 23 a a DT cord-023134-y665agnh 634 24 marked marked JJ cord-023134-y665agnh 634 25 increase increase NN cord-023134-y665agnh 634 26 in in IN cord-023134-y665agnh 634 27 uptake uptake NN cord-023134-y665agnh 634 28 in in IN cord-023134-y665agnh 634 29 some some DT cord-023134-y665agnh 634 30 tumors tumor NNS cord-023134-y665agnh 634 31 and and CC cord-023134-y665agnh 634 32 a a DT cord-023134-y665agnh 634 33 decrease decrease NN cord-023134-y665agnh 634 34 in in IN cord-023134-y665agnh 634 35 others other NNS cord-023134-y665agnh 634 36 . . . cord-023134-y665agnh 635 1 Further further JJ cord-023134-y665agnh 635 2 studies study NNS cord-023134-y665agnh 635 3 are be VBP cord-023134-y665agnh 635 4 necessary necessary JJ cord-023134-y665agnh 635 5 to to TO cord-023134-y665agnh 635 6 determine determine VB cord-023134-y665agnh 635 7 the the DT cord-023134-y665agnh 635 8 best good JJS cord-023134-y665agnh 635 9 dosage dosage NN cord-023134-y665agnh 635 10 , , , cord-023134-y665agnh 635 11 route route NN cord-023134-y665agnh 635 12 and and CC cord-023134-y665agnh 635 13 timing timing NN cord-023134-y665agnh 635 14 of of IN cord-023134-y665agnh 635 15 rhTSH rhtsh NN cord-023134-y665agnh 635 16 to to TO cord-023134-y665agnh 635 17 optimize optimize VB cord-023134-y665agnh 635 18 thyroid thyroid NN cord-023134-y665agnh 635 19 tumor tumor NN cord-023134-y665agnh 635 20 RAIU.This RAIU.This NNP cord-023134-y665agnh 635 21 study study NN cord-023134-y665agnh 635 22 was be VBD cord-023134-y665agnh 635 23 partly partly RB cord-023134-y665agnh 635 24 funded fund VBN cord-023134-y665agnh 635 25 by by IN cord-023134-y665agnh 635 26 the the DT cord-023134-y665agnh 635 27 Dutch Dutch NNP cord-023134-y665agnh 635 28 Animal Animal NNP cord-023134-y665agnh 635 29 Cancer Cancer NNP cord-023134-y665agnh 635 30 Foundation Foundation NNP cord-023134-y665agnh 635 31 Transdermal Transdermal NNP cord-023134-y665agnh 635 32 methimazole methimazole NN cord-023134-y665agnh 635 33 has have VBZ cord-023134-y665agnh 635 34 been be VBN cord-023134-y665agnh 635 35 suggested suggest VBN cord-023134-y665agnh 635 36 as as IN cord-023134-y665agnh 635 37 an an DT cord-023134-y665agnh 635 38 alternative alternative JJ cord-023134-y665agnh 635 39 treatment treatment NN cord-023134-y665agnh 635 40 option option NN cord-023134-y665agnh 635 41 of of IN cord-023134-y665agnh 635 42 hyperthyroid hyperthyroid JJ cord-023134-y665agnh 635 43 cats cat NNS cord-023134-y665agnh 635 44 . . . cord-023134-y665agnh 636 1 In in IN cord-023134-y665agnh 636 2 a a DT cord-023134-y665agnh 636 3 previous previous JJ cord-023134-y665agnh 636 4 study study NN cord-023134-y665agnh 636 5 we -PRON- PRP cord-023134-y665agnh 636 6 could could MD cord-023134-y665agnh 636 7 show show VB cord-023134-y665agnh 636 8 a a DT cord-023134-y665agnh 636 9 good good JJ cord-023134-y665agnh 636 10 clinical clinical JJ cord-023134-y665agnh 636 11 effectiveness effectiveness NN cord-023134-y665agnh 636 12 of of IN cord-023134-y665agnh 636 13 a a DT cord-023134-y665agnh 636 14 pleuronic pleuronic JJ cord-023134-y665agnh 636 15 lecithin lecithin NN cord-023134-y665agnh 636 16 organogel organogel VBN cord-023134-y665agnh 636 17 ( ( -LRB- cord-023134-y665agnh 636 18 PLO- PLO- NNP cord-023134-y665agnh 636 19 ) ) -RRB- cord-023134-y665agnh 636 20 based base VBN cord-023134-y665agnh 636 21 product product NN cord-023134-y665agnh 636 22 on on IN cord-023134-y665agnh 636 23 a a DT cord-023134-y665agnh 636 24 twice twice RB cord-023134-y665agnh 636 25 - - HYPH cord-023134-y665agnh 636 26 daily daily JJ cord-023134-y665agnh 636 27 basis basis NN cord-023134-y665agnh 636 28 . . . cord-023134-y665agnh 637 1 A a DT cord-023134-y665agnh 637 2 reduced reduce VBN cord-023134-y665agnh 637 3 dose dose NN cord-023134-y665agnh 637 4 frequency frequency NN cord-023134-y665agnh 637 5 is be VBZ cord-023134-y665agnh 637 6 known know VBN cord-023134-y665agnh 637 7 to to TO cord-023134-y665agnh 637 8 improve improve VB cord-023134-y665agnh 637 9 owner owner NN cord-023134-y665agnh 637 10 compliance compliance NN cord-023134-y665agnh 637 11 , , , cord-023134-y665agnh 637 12 however however RB cord-023134-y665agnh 637 13 no no DT cord-023134-y665agnh 637 14 study study NN cord-023134-y665agnh 637 15 has have VBZ cord-023134-y665agnh 637 16 yet yet RB cord-023134-y665agnh 637 17 evaluated evaluate VBN cord-023134-y665agnh 637 18 long long JJ cord-023134-y665agnh 637 19 - - HYPH cord-023134-y665agnh 637 20 term term NN cord-023134-y665agnh 637 21 treatment treatment NN cord-023134-y665agnh 637 22 responses response NNS cord-023134-y665agnh 637 23 after after IN cord-023134-y665agnh 637 24 once once RB cord-023134-y665agnh 637 25 daily daily JJ cord-023134-y665agnh 637 26 administration administration NN cord-023134-y665agnh 637 27 . . . cord-023134-y665agnh 638 1 Objectives objective NNS cord-023134-y665agnh 638 2 of of IN cord-023134-y665agnh 638 3 the the DT cord-023134-y665agnh 638 4 present present JJ cord-023134-y665agnh 638 5 study study NN cord-023134-y665agnh 638 6 were be VBD cord-023134-y665agnh 638 7 to to TO cord-023134-y665agnh 638 8 assess assess VB cord-023134-y665agnh 638 9 whether whether IN cord-023134-y665agnh 638 10 once once RB cord-023134-y665agnh 638 11 daily daily JJ cord-023134-y665agnh 638 12 administration administration NN cord-023134-y665agnh 638 13 of of IN cord-023134-y665agnh 638 14 transdermal transdermal NNP cord-023134-y665agnh 638 15 methimazole methimazole NNP cord-023134-y665agnh 638 16 in in IN cord-023134-y665agnh 638 17 its -PRON- PRP$ cord-023134-y665agnh 638 18 original original JJ cord-023134-y665agnh 638 19 formulation formulation NN cord-023134-y665agnh 638 20 of of IN cord-023134-y665agnh 638 21 ( ( -LRB- cord-023134-y665agnh 638 22 PLO PLO NNP cord-023134-y665agnh 638 23 ) ) -RRB- cord-023134-y665agnh 638 24 was be VBD cord-023134-y665agnh 638 25 an an DT cord-023134-y665agnh 638 26 effective effective JJ cord-023134-y665agnh 638 27 alternative alternative NN cord-023134-y665agnh 638 28 to to IN cord-023134-y665agnh 638 29 the the DT cord-023134-y665agnh 638 30 twice twice RB cord-023134-y665agnh 638 31 - - HYPH cord-023134-y665agnh 638 32 daily daily JJ cord-023134-y665agnh 638 33 treatment treatment NN cord-023134-y665agnh 638 34 during during IN cord-023134-y665agnh 638 35 a a DT cord-023134-y665agnh 638 36 follow follow NN cord-023134-y665agnh 638 37 - - HYPH cord-023134-y665agnh 638 38 up up NN cord-023134-y665agnh 638 39 period period NN cord-023134-y665agnh 638 40 of of IN cord-023134-y665agnh 638 41 up up IN cord-023134-y665agnh 638 42 to to TO cord-023134-y665agnh 638 43 18 18 CD cord-023134-y665agnh 638 44 months month NNS cord-023134-y665agnh 638 45 and and CC cord-023134-y665agnh 638 46 to to TO cord-023134-y665agnh 638 47 evaluate evaluate VB cord-023134-y665agnh 638 48 T4 T4 NNP cord-023134-y665agnh 638 49 courses course NNS cord-023134-y665agnh 638 50 during during IN cord-023134-y665agnh 638 51 a a DT cord-023134-y665agnh 638 52 10-hour 10-hour CD cord-023134-y665agnh 638 53 period period NN cord-023134-y665agnh 638 54 after after IN cord-023134-y665agnh 638 55 methimazole methimazole NN cord-023134-y665agnh 638 56 application application NN cord-023134-y665agnh 638 57 in in IN cord-023134-y665agnh 638 58 selected select VBN cord-023134-y665agnh 638 59 cats cat NNS cord-023134-y665agnh 638 60 . . . cord-023134-y665agnh 639 1 Twenty twenty CD cord-023134-y665agnh 639 2 client client NN cord-023134-y665agnh 639 3 - - HYPH cord-023134-y665agnh 639 4 owned own VBN cord-023134-y665agnh 639 5 cats cat NNS cord-023134-y665agnh 639 6 with with IN cord-023134-y665agnh 639 7 newly newly RB cord-023134-y665agnh 639 8 diagnosed diagnose VBN cord-023134-y665agnh 639 9 hyperthyroidism hyperthyroidism NN cord-023134-y665agnh 639 10 and and CC cord-023134-y665agnh 639 11 with with IN cord-023134-y665agnh 639 12 available available JJ cord-023134-y665agnh 639 13 follow follow NN cord-023134-y665agnh 639 14 - - HYPH cord-023134-y665agnh 639 15 up up RP cord-023134-y665agnh 639 16 information information NN cord-023134-y665agnh 639 17 were be VBD cord-023134-y665agnh 639 18 included include VBN cord-023134-y665agnh 639 19 in in IN cord-023134-y665agnh 639 20 the the DT cord-023134-y665agnh 639 21 study study NN cord-023134-y665agnh 639 22 . . . cord-023134-y665agnh 640 1 Methimazole Methimazole NNP cord-023134-y665agnh 640 2 was be VBD cord-023134-y665agnh 640 3 formulated formulate VBN cord-023134-y665agnh 640 4 in in IN cord-023134-y665agnh 640 5 PLObased plobased JJ cord-023134-y665agnh 640 6 vehicle vehicle NN cord-023134-y665agnh 640 7 and and CC cord-023134-y665agnh 640 8 was be VBD cord-023134-y665agnh 640 9 applied apply VBN cord-023134-y665agnh 640 10 to to IN cord-023134-y665agnh 640 11 the the DT cord-023134-y665agnh 640 12 pinna pinna NN cord-023134-y665agnh 640 13 of of IN cord-023134-y665agnh 640 14 the the DT cord-023134-y665agnh 640 15 inner inner JJ cord-023134-y665agnh 640 16 ear ear NN cord-023134-y665agnh 640 17 at at IN cord-023134-y665agnh 640 18 a a DT cord-023134-y665agnh 640 19 starting starting NN cord-023134-y665agnh 640 20 dose dose NN cord-023134-y665agnh 640 21 of of IN cord-023134-y665agnh 640 22 5mg 5mg NN cord-023134-y665agnh 640 23 / / SYM cord-023134-y665agnh 640 24 cat cat NN cord-023134-y665agnh 640 25 q q NNP cord-023134-y665agnh 640 26 24 24 CD cord-023134-y665agnh 640 27 hours hour NNS cord-023134-y665agnh 640 28 . . . cord-023134-y665agnh 641 1 Cats cat NNS cord-023134-y665agnh 641 2 were be VBD cord-023134-y665agnh 641 3 rechecked rechecke VBN cord-023134-y665agnh 641 4 1 1 CD cord-023134-y665agnh 641 5 - - SYM cord-023134-y665agnh 641 6 2 2 CD cord-023134-y665agnh 641 7 weeks week NNS cord-023134-y665agnh 641 8 , , , cord-023134-y665agnh 641 9 3 3 CD cord-023134-y665agnh 641 10 - - SYM cord-023134-y665agnh 641 11 4 4 CD cord-023134-y665agnh 641 12 weeks week NNS cord-023134-y665agnh 641 13 , , , cord-023134-y665agnh 641 14 1 1 CD cord-023134-y665agnh 641 15 - - SYM cord-023134-y665agnh 641 16 2 2 CD cord-023134-y665agnh 641 17 months month NNS cord-023134-y665agnh 641 18 , , , cord-023134-y665agnh 641 19 2 2 CD cord-023134-y665agnh 641 20 - - SYM cord-023134-y665agnh 641 21 3 3 CD cord-023134-y665agnh 641 22 months month NNS cord-023134-y665agnh 641 23 , , , cord-023134-y665agnh 641 24 3 3 CD cord-023134-y665agnh 641 25 - - SYM cord-023134-y665agnh 641 26 6 6 CD cord-023134-y665agnh 641 27 months month NNS cord-023134-y665agnh 641 28 , , , cord-023134-y665agnh 641 29 6 6 CD cord-023134-y665agnh 641 30 - - SYM cord-023134-y665agnh 641 31 12 12 CD cord-023134-y665agnh 641 32 and and CC cord-023134-y665agnh 641 33 12 12 CD cord-023134-y665agnh 641 34 - - SYM cord-023134-y665agnh 641 35 18 18 CD cord-023134-y665agnh 641 36 months month NNS cord-023134-y665agnh 641 37 after after IN cord-023134-y665agnh 641 38 starting start VBG cord-023134-y665agnh 641 39 therapy therapy NN cord-023134-y665agnh 641 40 . . . cord-023134-y665agnh 642 1 Additionally additionally RB cord-023134-y665agnh 642 2 , , , cord-023134-y665agnh 642 3 in in IN cord-023134-y665agnh 642 4 10 10 CD cord-023134-y665agnh 642 5 cats cat NNS cord-023134-y665agnh 642 6 T4 T4 NNP cord-023134-y665agnh 642 7 concentrations concentration NNS cord-023134-y665agnh 642 8 were be VBD cord-023134-y665agnh 642 9 measured measure VBN cord-023134-y665agnh 642 10 every every DT cord-023134-y665agnh 642 11 2 2 CD cord-023134-y665agnh 642 12 hours hour NNS cord-023134-y665agnh 642 13 after after IN cord-023134-y665agnh 642 14 gel gel NN cord-023134-y665agnh 642 15 application application NN cord-023134-y665agnh 642 16 over over IN cord-023134-y665agnh 642 17 a a DT cord-023134-y665agnh 642 18 10 10 CD cord-023134-y665agnh 642 19 hour hour NN cord-023134-y665agnh 642 20 period period NN cord-023134-y665agnh 642 21 1 1 CD cord-023134-y665agnh 642 22 week week NN cord-023134-y665agnh 642 23 after after IN cord-023134-y665agnh 642 24 starting start VBG cord-023134-y665agnh 642 25 therapy therapy NN cord-023134-y665agnh 642 26 . . . cord-023134-y665agnh 643 1 After after IN cord-023134-y665agnh 643 2 1 1 CD cord-023134-y665agnh 643 3 - - SYM cord-023134-y665agnh 643 4 2 2 CD cord-023134-y665agnh 643 5 weeks week NNS cord-023134-y665agnh 643 6 , , , cord-023134-y665agnh 643 7 clinical clinical JJ cord-023134-y665agnh 643 8 improvement improvement NN cord-023134-y665agnh 643 9 was be VBD cord-023134-y665agnh 643 10 observed observe VBN cord-023134-y665agnh 643 11 in in IN cord-023134-y665agnh 643 12 all all DT cord-023134-y665agnh 643 13 animals animal NNS cord-023134-y665agnh 643 14 . . . cord-023134-y665agnh 644 1 A a DT cord-023134-y665agnh 644 2 change change NN cord-023134-y665agnh 644 3 of of IN cord-023134-y665agnh 644 4 treatment treatment NN cord-023134-y665agnh 644 5 to to IN cord-023134-y665agnh 644 6 oral oral JJ cord-023134-y665agnh 644 7 medication medication NN cord-023134-y665agnh 644 8 due due IN cord-023134-y665agnh 644 9 to to IN cord-023134-y665agnh 644 10 erythema erythema NN cord-023134-y665agnh 644 11 of of IN cord-023134-y665agnh 644 12 the the DT cord-023134-y665agnh 644 13 internal internal JJ cord-023134-y665agnh 644 14 pinna pinna NN cord-023134-y665agnh 644 15 of of IN cord-023134-y665agnh 644 16 the the DT cord-023134-y665agnh 644 17 ears ear NNS cord-023134-y665agnh 644 18 was be VBD cord-023134-y665agnh 644 19 necessary necessary JJ cord-023134-y665agnh 644 20 in in IN cord-023134-y665agnh 644 21 one one CD cord-023134-y665agnh 644 22 cat cat NN cord-023134-y665agnh 644 23 , , , cord-023134-y665agnh 644 24 while while IN cord-023134-y665agnh 644 25 none none NN cord-023134-y665agnh 644 26 of of IN cord-023134-y665agnh 644 27 the the DT cord-023134-y665agnh 644 28 other other JJ cord-023134-y665agnh 644 29 animals animal NNS cord-023134-y665agnh 644 30 showed show VBD cord-023134-y665agnh 644 31 any any DT cord-023134-y665agnh 644 32 side side NN cord-023134-y665agnh 644 33 effects effect NNS cord-023134-y665agnh 644 34 during during IN cord-023134-y665agnh 644 35 the the DT cord-023134-y665agnh 644 36 follow follow NN cord-023134-y665agnh 644 37 - - HYPH cord-023134-y665agnh 644 38 up up NN cord-023134-y665agnh 644 39 period period NN cord-023134-y665agnh 644 40 . . . cord-023134-y665agnh 645 1 Significant significant JJ cord-023134-y665agnh 645 2 decreases decrease NNS cord-023134-y665agnh 645 3 in in IN cord-023134-y665agnh 645 4 T4 T4 NNP cord-023134-y665agnh 645 5 concentrations concentration NNS cord-023134-y665agnh 645 6 were be VBD cord-023134-y665agnh 645 7 determined determine VBN cord-023134-y665agnh 645 8 at at IN cord-023134-y665agnh 645 9 all all RB cord-023134-y665agnh 645 10 rechecks recheck NNS cord-023134-y665agnh 645 11 compared compare VBN cord-023134-y665agnh 645 12 to to IN cord-023134-y665agnh 645 13 pre pre JJ cord-023134-y665agnh 645 14 - - JJ cord-023134-y665agnh 645 15 treatment treatment JJ cord-023134-y665agnh 645 16 concentrations concentration NNS cord-023134-y665agnh 645 17 . . . cord-023134-y665agnh 646 1 Methimazole Methimazole NNP cord-023134-y665agnh 646 2 dosage dosage NN cord-023134-y665agnh 646 3 was be VBD cord-023134-y665agnh 646 4 increased increase VBN cord-023134-y665agnh 646 5 in in IN cord-023134-y665agnh 646 6 5 5 CD cord-023134-y665agnh 646 7 , , , cord-023134-y665agnh 646 8 decreased decrease VBD cord-023134-y665agnh 646 9 in in IN cord-023134-y665agnh 646 10 11 11 CD cord-023134-y665agnh 646 11 and and CC cord-023134-y665agnh 646 12 remained remain VBD cord-023134-y665agnh 646 13 unchanged unchanged JJ cord-023134-y665agnh 646 14 in in IN cord-023134-y665agnh 646 15 4 4 CD cord-023134-y665agnh 646 16 cats cat NNS cord-023134-y665agnh 646 17 . . . cord-023134-y665agnh 647 1 Two two CD cord-023134-y665agnh 647 2 cats cat NNS cord-023134-y665agnh 647 3 with with IN cord-023134-y665agnh 647 4 a a DT cord-023134-y665agnh 647 5 decrease decrease NN cord-023134-y665agnh 647 6 in in IN cord-023134-y665agnh 647 7 the the DT cord-023134-y665agnh 647 8 dose dose NN cord-023134-y665agnh 647 9 later later RB cord-023134-y665agnh 647 10 had have VBD cord-023134-y665agnh 647 11 to to TO cord-023134-y665agnh 647 12 be be VB cord-023134-y665agnh 647 13 re re VBN cord-023134-y665agnh 647 14 - - VBN cord-023134-y665agnh 647 15 increased increase VBN cord-023134-y665agnh 647 16 , , , cord-023134-y665agnh 647 17 while while IN cord-023134-y665agnh 647 18 one one CD cord-023134-y665agnh 647 19 cat cat NN cord-023134-y665agnh 647 20 was be VBD cord-023134-y665agnh 647 21 changed change VBN cord-023134-y665agnh 647 22 to to IN cord-023134-y665agnh 647 23 q12 q12 NN cord-023134-y665agnh 647 24 hours hour NNS cord-023134-y665agnh 647 25 . . . cord-023134-y665agnh 648 1 There there EX cord-023134-y665agnh 648 2 was be VBD cord-023134-y665agnh 648 3 no no DT cord-023134-y665agnh 648 4 significant significant JJ cord-023134-y665agnh 648 5 change change NN cord-023134-y665agnh 648 6 in in IN cord-023134-y665agnh 648 7 T4 T4 NNP cord-023134-y665agnh 648 8 during during IN cord-023134-y665agnh 648 9 the the DT cord-023134-y665agnh 648 10 10-hour 10-hour CD cord-023134-y665agnh 648 11 period period NN cord-023134-y665agnh 648 12 and and CC cord-023134-y665agnh 648 13 fluctuations fluctuation NNS cord-023134-y665agnh 648 14 corresponded correspond VBD cord-023134-y665agnh 648 15 to to IN cord-023134-y665agnh 648 16 variations variation NNS cord-023134-y665agnh 648 17 of of IN cord-023134-y665agnh 648 18 precision precision NN cord-023134-y665agnh 648 19 in in IN cord-023134-y665agnh 648 20 series series NN cord-023134-y665agnh 648 21 . . . cord-023134-y665agnh 649 1 These these DT cord-023134-y665agnh 649 2 results result NNS cord-023134-y665agnh 649 3 are be VBP cord-023134-y665agnh 649 4 in in IN cord-023134-y665agnh 649 5 accordance accordance NN cord-023134-y665agnh 649 6 with with IN cord-023134-y665agnh 649 7 those those DT cord-023134-y665agnh 649 8 of of IN cord-023134-y665agnh 649 9 our -PRON- PRP$ cord-023134-y665agnh 649 10 previous previous JJ cord-023134-y665agnh 649 11 study study NN cord-023134-y665agnh 649 12 using use VBG cord-023134-y665agnh 649 13 the the DT cord-023134-y665agnh 649 14 twicedaily twicedaily NNP cord-023134-y665agnh 649 15 regimen regimen NN cord-023134-y665agnh 649 16 . . . cord-023134-y665agnh 650 1 We -PRON- PRP cord-023134-y665agnh 650 2 could could MD cord-023134-y665agnh 650 3 show show VB cord-023134-y665agnh 650 4 that that IN cord-023134-y665agnh 650 5 once once RB cord-023134-y665agnh 650 6 daily daily JJ cord-023134-y665agnh 650 7 administration administration NN cord-023134-y665agnh 650 8 of of IN cord-023134-y665agnh 650 9 transdermal transdermal NNP cord-023134-y665agnh 650 10 methimazole methimazole NNP cord-023134-y665agnh 650 11 in in IN cord-023134-y665agnh 650 12 its -PRON- PRP$ cord-023134-y665agnh 650 13 original original JJ cord-023134-y665agnh 650 14 formulation formulation NN cord-023134-y665agnh 650 15 of of IN cord-023134-y665agnh 650 16 PLO PLO NNP cord-023134-y665agnh 650 17 is be VBZ cord-023134-y665agnh 650 18 an an DT cord-023134-y665agnh 650 19 effective effective JJ cord-023134-y665agnh 650 20 treatment treatment NN cord-023134-y665agnh 650 21 option option NN cord-023134-y665agnh 650 22 for for IN cord-023134-y665agnh 650 23 long long JJ cord-023134-y665agnh 650 24 - - HYPH cord-023134-y665agnh 650 25 term term NN cord-023134-y665agnh 650 26 management management NN cord-023134-y665agnh 650 27 of of IN cord-023134-y665agnh 650 28 feline feline JJ cord-023134-y665agnh 650 29 hyperthyroidism hyperthyroidism NN cord-023134-y665agnh 650 30 . . . cord-023134-y665agnh 651 1 Further further RB cord-023134-y665agnh 651 2 , , , cord-023134-y665agnh 651 3 timing timing NN cord-023134-y665agnh 651 4 of of IN cord-023134-y665agnh 651 5 blood blood NN cord-023134-y665agnh 651 6 sampling sampling NN cord-023134-y665agnh 651 7 after after IN cord-023134-y665agnh 651 8 gel gel NN cord-023134-y665agnh 651 9 application application NN cord-023134-y665agnh 651 10 is be VBZ cord-023134-y665agnh 651 11 not not RB cord-023134-y665agnh 651 12 important important JJ cord-023134-y665agnh 651 13 when when WRB cord-023134-y665agnh 651 14 assessing assess VBG cord-023134-y665agnh 651 15 response response NN cord-023134-y665agnh 651 16 to to IN cord-023134-y665agnh 651 17 treatment treatment NN cord-023134-y665agnh 651 18 . . . cord-023134-y665agnh 652 1 INCREASE INCREASE VBN cord-023134-y665agnh 652 2 IN in IN cord-023134-y665agnh 652 3 THE the DT cord-023134-y665agnh 652 4 _SP cord-023134-y665agnh 652 5 PREVALENCE prevalence NN cord-023134-y665agnh 652 6 OF of IN cord-023134-y665agnh 652 7 LARGE large JJ cord-023134-y665agnh 652 8 THYROID thyroid NN cord-023134-y665agnh 652 9 TUMORS tumor NNS cord-023134-y665agnh 652 10 , , , cord-023134-y665agnh 652 11 INTRA intra JJ cord-023134-y665agnh 652 12 - - JJ cord-023134-y665agnh 652 13 THORACIC thoracic JJ cord-023134-y665agnh 652 14 THYROID thyroid NN cord-023134-y665agnh 653 1 Thyroid thyroid NN cord-023134-y665agnh 653 2 scintigraphy scintigraphy NN cord-023134-y665agnh 653 3 provides provide VBZ cord-023134-y665agnh 653 4 valuable valuable JJ cord-023134-y665agnh 653 5 information information NN cord-023134-y665agnh 653 6 regarding regard VBG cord-023134-y665agnh 653 7 both both CC cord-023134-y665agnh 653 8 thyroid thyroid JJ cord-023134-y665agnh 653 9 anatomy anatomy NN cord-023134-y665agnh 653 10 and and CC cord-023134-y665agnh 653 11 physiology physiology NN cord-023134-y665agnh 653 12 and and CC cord-023134-y665agnh 653 13 plays play VBZ cord-023134-y665agnh 653 14 an an DT cord-023134-y665agnh 653 15 integral integral JJ cord-023134-y665agnh 653 16 role role NN cord-023134-y665agnh 653 17 in in IN cord-023134-y665agnh 653 18 the the DT cord-023134-y665agnh 653 19 diagnosis diagnosis NN cord-023134-y665agnh 653 20 , , , cord-023134-y665agnh 653 21 staging staging NN cord-023134-y665agnh 653 22 , , , cord-023134-y665agnh 653 23 and and CC cord-023134-y665agnh 653 24 management management NN cord-023134-y665agnh 653 25 of of IN cord-023134-y665agnh 653 26 feline feline JJ cord-023134-y665agnh 653 27 thyroid thyroid NN cord-023134-y665agnh 653 28 disease disease NN cord-023134-y665agnh 653 29 . . . cord-023134-y665agnh 654 1 In in IN cord-023134-y665agnh 654 2 this this DT cord-023134-y665agnh 654 3 study study NN cord-023134-y665agnh 654 4 , , , cord-023134-y665agnh 654 5 we -PRON- PRP cord-023134-y665agnh 654 6 performed perform VBD cord-023134-y665agnh 654 7 thyroid thyroid NN cord-023134-y665agnh 654 8 imaging image VBG cord-023134-y665agnh 654 9 on on IN cord-023134-y665agnh 654 10 1,572 1,572 CD cord-023134-y665agnh 654 11 consecutive consecutive JJ cord-023134-y665agnh 654 12 hyperthyroid hyperthyroid JJ cord-023134-y665agnh 654 13 cats cat NNS cord-023134-y665agnh 654 14 that that WDT cord-023134-y665agnh 654 15 were be VBD cord-023134-y665agnh 654 16 referred refer VBN cord-023134-y665agnh 654 17 for for IN cord-023134-y665agnh 654 18 radioiodine radioiodine NN cord-023134-y665agnh 654 19 therapy therapy NN cord-023134-y665agnh 654 20 between between IN cord-023134-y665agnh 654 21 January January NNP cord-023134-y665agnh 654 22 2009 2009 CD cord-023134-y665agnh 654 23 and and CC cord-023134-y665agnh 654 24 December December NNP cord-023134-y665agnh 654 25 2011 2011 CD cord-023134-y665agnh 654 26 . . . cord-023134-y665agnh 655 1 Scintigraphy Scintigraphy NNP cord-023134-y665agnh 655 2 was be VBD cord-023134-y665agnh 655 3 performed perform VBN cord-023134-y665agnh 655 4 as as IN cord-023134-y665agnh 655 5 part part NN cord-023134-y665agnh 655 6 of of IN cord-023134-y665agnh 655 7 our -PRON- PRP$ cord-023134-y665agnh 655 8 staging stage VBG cord-023134-y665agnh 655 9 protocol protocol NN cord-023134-y665agnh 655 10 in in IN cord-023134-y665agnh 655 11 which which WDT cord-023134-y665agnh 655 12 thyroid thyroid NN cord-023134-y665agnh 655 13 volume volume NN cord-023134-y665agnh 655 14 is be VBZ cord-023134-y665agnh 655 15 estimated estimate VBN cord-023134-y665agnh 655 16 for for IN cord-023134-y665agnh 655 17 131 131 CD cord-023134-y665agnh 655 18 I -PRON- PRP cord-023134-y665agnh 655 19 dose dose VBP cord-023134-y665agnh 655 20 estimation estimation NN cord-023134-y665agnh 655 21 ( ( -LRB- cord-023134-y665agnh 655 22 Vet Vet NNP cord-023134-y665agnh 655 23 Radiol Radiol NNP cord-023134-y665agnh 655 24 Ultrasound Ultrasound NNP cord-023134-y665agnh 655 25 1996 1996 CD cord-023134-y665agnh 655 26 ; ; : cord-023134-y665agnh 655 27 27:141 27:141 CD cord-023134-y665agnh 655 28 ) ) -RRB- cord-023134-y665agnh 655 29 . . . cord-023134-y665agnh 656 1 In in IN cord-023134-y665agnh 656 2 each each DT cord-023134-y665agnh 656 3 cat cat NN cord-023134-y665agnh 656 4 , , , cord-023134-y665agnh 656 5 the the DT cord-023134-y665agnh 656 6 location location NN cord-023134-y665agnh 656 7 of of IN cord-023134-y665agnh 656 8 each each DT cord-023134-y665agnh 656 9 area area NN cord-023134-y665agnh 656 10 of of IN cord-023134-y665agnh 656 11 increased increase VBN cord-023134-y665agnh 656 12 radionuclide radionuclide NN cord-023134-y665agnh 656 13 uptake uptake NN cord-023134-y665agnh 656 14 ( ( -LRB- cord-023134-y665agnh 656 15 IRU IRU NNP cord-023134-y665agnh 656 16 ) ) -RRB- cord-023134-y665agnh 656 17 was be VBD cord-023134-y665agnh 656 18 also also RB cord-023134-y665agnh 656 19 recorded record VBN cord-023134-y665agnh 656 20 ( ( -LRB- cord-023134-y665agnh 656 21 cervical cervical JJ cord-023134-y665agnh 656 22 , , , cord-023134-y665agnh 656 23 thoracic thoracic JJ cord-023134-y665agnh 656 24 inlet inlet NN cord-023134-y665agnh 656 25 , , , cord-023134-y665agnh 656 26 chest chest NN cord-023134-y665agnh 656 27 ) ) -RRB- cord-023134-y665agnh 656 28 . . . cord-023134-y665agnh 657 1 Finally finally RB cord-023134-y665agnh 657 2 , , , cord-023134-y665agnh 657 3 each each DT cord-023134-y665agnh 657 4 scan scan NN cord-023134-y665agnh 657 5 was be VBD cord-023134-y665agnh 657 6 evaluated evaluate VBN cord-023134-y665agnh 657 7 for for IN cord-023134-y665agnh 657 8 features feature NNS cord-023134-y665agnh 657 9 suggesting suggest VBG cord-023134-y665agnh 657 10 malignancy malignancy NN cord-023134-y665agnh 657 11 ( ( -LRB- cord-023134-y665agnh 657 12 multiple multiple JJ cord-023134-y665agnh 657 13 , , , cord-023134-y665agnh 657 14 extensive extensive JJ cord-023134-y665agnh 657 15 areas area NNS cord-023134-y665agnh 657 16 of of IN cord-023134-y665agnh 657 17 IRU IRU NNP cord-023134-y665agnh 657 18 , , , cord-023134-y665agnh 657 19 heterogeneous heterogeneous JJ cord-023134-y665agnh 657 20 pattern pattern NN cord-023134-y665agnh 657 21 of of IN cord-023134-y665agnh 657 22 IRU IRU NNP cord-023134-y665agnh 657 23 with with IN cord-023134-y665agnh 657 24 irregular irregular JJ cord-023134-y665agnh 657 25 , , , cord-023134-y665agnh 657 26 spiculated spiculated JJ cord-023134-y665agnh 657 27 margins margin NNS cord-023134-y665agnh 657 28 , , , cord-023134-y665agnh 657 29 extension extension NN cord-023134-y665agnh 657 30 of of IN cord-023134-y665agnh 657 31 tumor tumor NN cord-023134-y665agnh 657 32 through through IN cord-023134-y665agnh 657 33 thoracic thoracic JJ cord-023134-y665agnh 657 34 inlet inlet NN cord-023134-y665agnh 657 35 into into IN cord-023134-y665agnh 657 36 the the DT cord-023134-y665agnh 657 37 thorax thorax NN cord-023134-y665agnh 657 38 , , , cord-023134-y665agnh 657 39 and and CC cord-023134-y665agnh 657 40 metastasis metastasis NN cord-023134-y665agnh 657 41 to to IN cord-023134-y665agnh 657 42 regional regional JJ cord-023134-y665agnh 657 43 lymph lymph NN cord-023134-y665agnh 657 44 nodes node NNS cord-023134-y665agnh 657 45 or or CC cord-023134-y665agnh 657 46 lung).Of lung).Of VBD cord-023134-y665agnh 657 47 the the DT cord-023134-y665agnh 657 48 1,572 1,572 CD cord-023134-y665agnh 657 49 cats cat NNS cord-023134-y665agnh 657 50 , , , cord-023134-y665agnh 657 51 most most RBS cord-023134-y665agnh 657 52 had have VBD cord-023134-y665agnh 657 53 been be VBN cord-023134-y665agnh 657 54 recently recently RB cord-023134-y665agnh 657 55 diagnosed diagnose VBN cord-023134-y665agnh 657 56 . . . cord-023134-y665agnh 658 1 In in IN cord-023134-y665agnh 658 2 228 228 CD cord-023134-y665agnh 658 3 cats cat NNS cord-023134-y665agnh 658 4 , , , cord-023134-y665agnh 658 5 however however RB cord-023134-y665agnh 658 6 , , , cord-023134-y665agnh 658 7 the the DT cord-023134-y665agnh 658 8 interval interval NN cord-023134-y665agnh 658 9 between between IN cord-023134-y665agnh 658 10 diagnosis diagnosis NN cord-023134-y665agnh 658 11 and and CC cord-023134-y665agnh 658 12 131 131 CD cord-023134-y665agnh 659 1 I -PRON- PRP cord-023134-y665agnh 659 2 treatment treatment NN cord-023134-y665agnh 659 3 ranged range VBD cord-023134-y665agnh 659 4 from from IN cord-023134-y665agnh 659 5 > > XX cord-023134-y665agnh 659 6 1 1 CD cord-023134-y665agnh 659 7 to to IN cord-023134-y665agnh 659 8 6.1 6.1 CD cord-023134-y665agnh 659 9 years year NNS cord-023134-y665agnh 659 10 ; ; : cord-023134-y665agnh 659 11 almost almost RB cord-023134-y665agnh 659 12 all all DT cord-023134-y665agnh 659 13 of of IN cord-023134-y665agnh 659 14 these these DT cord-023134-y665agnh 659 15 cats cat NNS cord-023134-y665agnh 659 16 had have VBD cord-023134-y665agnh 659 17 received receive VBN cord-023134-y665agnh 659 18 long long JJ cord-023134-y665agnh 659 19 - - HYPH cord-023134-y665agnh 659 20 term term NN cord-023134-y665agnh 659 21 antithyroid antithyroid NNP cord-023134-y665agnh 659 22 drug drug NN cord-023134-y665agnh 659 23 treatment treatment NN cord-023134-y665agnh 659 24 . . . cord-023134-y665agnh 660 1 The the DT cord-023134-y665agnh 660 2 1,572 1,572 CD cord-023134-y665agnh 660 3 cats cat NNS cord-023134-y665agnh 660 4 were be VBD cord-023134-y665agnh 660 5 divided divide VBN cord-023134-y665agnh 660 6 into into IN cord-023134-y665agnh 660 7 5 5 CD cord-023134-y665agnh 660 8 groups group NNS cord-023134-y665agnh 660 9 based base VBN cord-023134-y665agnh 660 10 on on IN cord-023134-y665agnh 660 11 interval interval NN cord-023134-y665agnh 660 12 from from IN cord-023134-y665agnh 660 13 diagnosis diagnosis NN cord-023134-y665agnh 660 14 to to IN cord-023134-y665agnh 660 15 131 131 CD cord-023134-y665agnh 660 16 I i NN cord-023134-y665agnh 660 17 treatment treatment NN cord-023134-y665agnh 660 18 : : : cord-023134-y665agnh 661 1 Group group NN cord-023134-y665agnh 661 2 1 1 CD cord-023134-y665agnh 661 3 ( ( -LRB- cord-023134-y665agnh 661 4 0 0 CD cord-023134-y665agnh 661 5 - - SYM cord-023134-y665agnh 661 6 1 1 CD cord-023134-y665agnh 661 7 year year NN cord-023134-y665agnh 661 8 ) ) -RRB- cord-023134-y665agnh 661 9 , , , cord-023134-y665agnh 661 10 1,344 1,344 CD cord-023134-y665agnh 661 11 cats cat NNS cord-023134-y665agnh 661 12 ; ; : cord-023134-y665agnh 661 13 Group group NN cord-023134-y665agnh 661 14 2 2 CD cord-023134-y665agnh 661 15 ( ( -LRB- cord-023134-y665agnh 661 16 > > NFP cord-023134-y665agnh 661 17 1 1 CD cord-023134-y665agnh 661 18 - - SYM cord-023134-y665agnh 661 19 2 2 CD cord-023134-y665agnh 661 20 years year NNS cord-023134-y665agnh 661 21 ) ) -RRB- cord-023134-y665agnh 661 22 , , , cord-023134-y665agnh 661 23 114 114 CD cord-023134-y665agnh 661 24 cats cat NNS cord-023134-y665agnh 661 25 ; ; : cord-023134-y665agnh 661 26 Group group NN cord-023134-y665agnh 661 27 3 3 CD cord-023134-y665agnh 661 28 ( ( -LRB- cord-023134-y665agnh 661 29 > > NFP cord-023134-y665agnh 661 30 2 2 CD cord-023134-y665agnh 661 31 - - SYM cord-023134-y665agnh 661 32 3 3 CD cord-023134-y665agnh 661 33 years year NNS cord-023134-y665agnh 661 34 ) ) -RRB- cord-023134-y665agnh 661 35 , , , cord-023134-y665agnh 661 36 62 62 CD cord-023134-y665agnh 661 37 cats cat NNS cord-023134-y665agnh 661 38 ; ; : cord-023134-y665agnh 661 39 Group group NN cord-023134-y665agnh 661 40 4 4 CD cord-023134-y665agnh 661 41 ( ( -LRB- cord-023134-y665agnh 661 42 > > NFP cord-023134-y665agnh 661 43 3 3 CD cord-023134-y665agnh 661 44 - - SYM cord-023134-y665agnh 661 45 4 4 CD cord-023134-y665agnh 661 46 years year NNS cord-023134-y665agnh 661 47 ) ) -RRB- cord-023134-y665agnh 661 48 , , , cord-023134-y665agnh 661 49 29 29 CD cord-023134-y665agnh 661 50 cats cat NNS cord-023134-y665agnh 661 51 ; ; : cord-023134-y665agnh 661 52 and and CC cord-023134-y665agnh 661 53 Group group NN cord-023134-y665agnh 661 54 5 5 CD cord-023134-y665agnh 661 55 ( ( -LRB- cord-023134-y665agnh 661 56 > > NFP cord-023134-y665agnh 661 57 4 4 CD cord-023134-y665agnh 661 58 - - SYM cord-023134-y665agnh 661 59 6.1 6.1 CD cord-023134-y665agnh 661 60 years year NNS cord-023134-y665agnh 661 61 ) ) -RRB- cord-023134-y665agnh 661 62 , , , cord-023134-y665agnh 661 63 23 23 CD cord-023134-y665agnh 661 64 cats cat NNS cord-023134-y665agnh 661 65 . . . cord-023134-y665agnh 662 1 When when WRB cord-023134-y665agnh 662 2 the the DT cord-023134-y665agnh 662 3 estimated estimate VBN cord-023134-y665agnh 662 4 thyroid thyroid NN cord-023134-y665agnh 662 5 volumes volume NNS cord-023134-y665agnh 662 6 in in IN cord-023134-y665agnh 662 7 the the DT cord-023134-y665agnh 662 8 5 5 CD cord-023134-y665agnh 662 9 groups group NNS cord-023134-y665agnh 662 10 of of IN cord-023134-y665agnh 662 11 cats cat NNS cord-023134-y665agnh 662 12 were be VBD cord-023134-y665agnh 662 13 compared compare VBN cord-023134-y665agnh 662 14 , , , cord-023134-y665agnh 662 15 a a DT cord-023134-y665agnh 662 16 progressive progressive JJ cord-023134-y665agnh 662 17 , , , cord-023134-y665agnh 662 18 significant significant JJ cord-023134-y665agnh 662 19 ( ( -LRB- cord-023134-y665agnh 662 20 P p NN cord-023134-y665agnh 662 21 < < XX cord-023134-y665agnh 662 22 0.001 0.001 CD cord-023134-y665agnh 662 23 ) ) -RRB- cord-023134-y665agnh 662 24 increase increase NN cord-023134-y665agnh 662 25 in in IN cord-023134-y665agnh 662 26 median median JJ cord-023134-y665agnh 662 27 tumor tumor NN cord-023134-y665agnh 662 28 volume volume NN cord-023134-y665agnh 662 29 occurred occur VBD cord-023134-y665agnh 662 30 : : : cord-023134-y665agnh 662 31 2.1 2.1 CD cord-023134-y665agnh 662 32 cm cm NNS cord-023134-y665agnh 662 33 3 3 CD cord-023134-y665agnh 662 34 ( ( -LRB- cord-023134-y665agnh 662 35 Group Group NNP cord-023134-y665agnh 662 36 1 1 CD cord-023134-y665agnh 662 37 ) ) -RRB- cord-023134-y665agnh 662 38 ; ; : cord-023134-y665agnh 662 39 4.1 4.1 CD cord-023134-y665agnh 662 40 cm cm NNS cord-023134-y665agnh 662 41 3 3 CD cord-023134-y665agnh 662 42 ( ( -LRB- cord-023134-y665agnh 662 43 Group Group NNP cord-023134-y665agnh 662 44 2 2 CD cord-023134-y665agnh 662 45 ) ) -RRB- cord-023134-y665agnh 662 46 ; ; : cord-023134-y665agnh 662 47 5.7 5.7 CD cord-023134-y665agnh 662 48 cm cm NNS cord-023134-y665agnh 662 49 3 3 CD cord-023134-y665agnh 662 50 ( ( -LRB- cord-023134-y665agnh 662 51 Group Group NNP cord-023134-y665agnh 662 52 3 3 CD cord-023134-y665agnh 662 53 ) ) -RRB- cord-023134-y665agnh 662 54 ; ; : cord-023134-y665agnh 662 55 6.1 6.1 CD cord-023134-y665agnh 662 56 cm cm NNS cord-023134-y665agnh 662 57 3 3 CD cord-023134-y665agnh 662 58 ( ( -LRB- cord-023134-y665agnh 662 59 Group Group NNP cord-023134-y665agnh 662 60 4 4 CD cord-023134-y665agnh 662 61 ) ) -RRB- cord-023134-y665agnh 662 62 ; ; : cord-023134-y665agnh 662 63 and and CC cord-023134-y665agnh 662 64 7.7 7.7 CD cord-023134-y665agnh 662 65 cm cm NNS cord-023134-y665agnh 662 66 3 3 CD cord-023134-y665agnh 662 67 ( ( -LRB- cord-023134-y665agnh 662 68 Group Group NNP cord-023134-y665agnh 662 69 5 5 CD cord-023134-y665agnh 662 70 ) ) -RRB- cord-023134-y665agnh 662 71 . . . cord-023134-y665agnh 663 1 The the DT cord-023134-y665agnh 663 2 prevalence prevalence NN cord-023134-y665agnh 663 3 of of IN cord-023134-y665agnh 663 4 cats cat NNS cord-023134-y665agnh 663 5 with with IN cord-023134-y665agnh 663 6 areas area NNS cord-023134-y665agnh 663 7 of of IN cord-023134-y665agnh 663 8 IRU IRU NNP cord-023134-y665agnh 663 9 within within IN cord-023134-y665agnh 663 10 the the DT cord-023134-y665agnh 663 11 thoracic thoracic JJ cord-023134-y665agnh 663 12 cavity cavity NN cord-023134-y665agnh 663 13 also also RB cord-023134-y665agnh 663 14 increased increase VBD cord-023134-y665agnh 663 15 progressively progressively RB cord-023134-y665agnh 663 16 : : : cord-023134-y665agnh 663 17 5.1 5.1 CD cord-023134-y665agnh 663 18 % % NN cord-023134-y665agnh 663 19 ( ( -LRB- cord-023134-y665agnh 663 20 Group Group NNP cord-023134-y665agnh 663 21 1 1 CD cord-023134-y665agnh 663 22 ) ) -RRB- cord-023134-y665agnh 663 23 ; ; : cord-023134-y665agnh 663 24 7.9 7.9 CD cord-023134-y665agnh 663 25 % % NN cord-023134-y665agnh 663 26 ( ( -LRB- cord-023134-y665agnh 663 27 Group Group NNP cord-023134-y665agnh 663 28 2 2 CD cord-023134-y665agnh 663 29 ) ) -RRB- cord-023134-y665agnh 663 30 ; ; : cord-023134-y665agnh 663 31 14.5 14.5 CD cord-023134-y665agnh 663 32 % % NN cord-023134-y665agnh 663 33 ( ( -LRB- cord-023134-y665agnh 663 34 Group Group NNP cord-023134-y665agnh 663 35 3 3 CD cord-023134-y665agnh 663 36 ) ) -RRB- cord-023134-y665agnh 663 37 ; ; : cord-023134-y665agnh 663 38 17.2 17.2 CD cord-023134-y665agnh 663 39 % % NN cord-023134-y665agnh 663 40 ( ( -LRB- cord-023134-y665agnh 663 41 Group Group NNP cord-023134-y665agnh 663 42 4 4 CD cord-023134-y665agnh 663 43 ) ) -RRB- cord-023134-y665agnh 663 44 ; ; : cord-023134-y665agnh 663 45 and and CC cord-023134-y665agnh 663 46 26.1 26.1 CD cord-023134-y665agnh 663 47 % % NN cord-023134-y665agnh 663 48 ( ( -LRB- cord-023134-y665agnh 663 49 Group Group NNP cord-023134-y665agnh 663 50 5 5 CD cord-023134-y665agnh 663 51 ) ) -RRB- cord-023134-y665agnh 663 52 . . . cord-023134-y665agnh 664 1 Finally finally RB cord-023134-y665agnh 664 2 , , , cord-023134-y665agnh 664 3 the the DT cord-023134-y665agnh 664 4 prevalence prevalence NN cord-023134-y665agnh 664 5 of of IN cord-023134-y665agnh 664 6 suspected suspect VBN cord-023134-y665agnh 664 7 thyroid thyroid NN cord-023134-y665agnh 664 8 carcinoma carcinoma NN cord-023134-y665agnh 664 9 ( ( -LRB- cord-023134-y665agnh 664 10 25 25 CD cord-023134-y665agnh 664 11 of of IN cord-023134-y665agnh 664 12 the the DT cord-023134-y665agnh 664 13 1,572 1,572 CD cord-023134-y665agnh 664 14 cats cat NNS cord-023134-y665agnh 664 15 ) ) -RRB- cord-023134-y665agnh 664 16 also also RB cord-023134-y665agnh 664 17 increased increase VBD cord-023134-y665agnh 664 18 progressively progressively RB cord-023134-y665agnh 664 19 : : : cord-023134-y665agnh 664 20 0.7 0.7 CD cord-023134-y665agnh 664 21 % % NN cord-023134-y665agnh 664 22 ( ( -LRB- cord-023134-y665agnh 664 23 Group Group NNP cord-023134-y665agnh 664 24 1 1 CD cord-023134-y665agnh 664 25 ) ) -RRB- cord-023134-y665agnh 664 26 ; ; : cord-023134-y665agnh 664 27 3.5 3.5 CD cord-023134-y665agnh 664 28 % % NN cord-023134-y665agnh 664 29 ( ( -LRB- cord-023134-y665agnh 664 30 Group Group NNP cord-023134-y665agnh 664 31 2 2 CD cord-023134-y665agnh 664 32 ) ) -RRB- cord-023134-y665agnh 664 33 ; ; : cord-023134-y665agnh 664 34 6.5 6.5 CD cord-023134-y665agnh 664 35 % % NN cord-023134-y665agnh 664 36 ( ( -LRB- cord-023134-y665agnh 664 37 Group Group NNP cord-023134-y665agnh 664 38 3 3 CD cord-023134-y665agnh 664 39 ) ) -RRB- cord-023134-y665agnh 664 40 ; ; : cord-023134-y665agnh 664 41 10.4 10.4 CD cord-023134-y665agnh 664 42 % % NN cord-023134-y665agnh 664 43 ( ( -LRB- cord-023134-y665agnh 664 44 Group Group NNP cord-023134-y665agnh 664 45 4 4 CD cord-023134-y665agnh 664 46 ) ) -RRB- cord-023134-y665agnh 664 47 ; ; : cord-023134-y665agnh 664 48 and and CC cord-023134-y665agnh 664 49 21.7 21.7 CD cord-023134-y665agnh 664 50 % % NN cord-023134-y665agnh 664 51 ( ( -LRB- cord-023134-y665agnh 664 52 Group Group NNP cord-023134-y665agnh 664 53 5 5 CD cord-023134-y665agnh 664 54 ) ) -RRB- cord-023134-y665agnh 664 55 . . . cord-023134-y665agnh 665 1 In in IN cord-023134-y665agnh 665 2 contrast contrast NN cord-023134-y665agnh 665 3 , , , cord-023134-y665agnh 665 4 no no DT cord-023134-y665agnh 665 5 increase increase NN cord-023134-y665agnh 665 6 in in IN cord-023134-y665agnh 665 7 prevalence prevalence NN cord-023134-y665agnh 665 8 of of IN cord-023134-y665agnh 665 9 ectopic ectopic JJ cord-023134-y665agnh 665 10 thyroid thyroid NN cord-023134-y665agnh 665 11 tissue tissue NN cord-023134-y665agnh 665 12 was be VBD cord-023134-y665agnh 665 13 found find VBN cord-023134-y665agnh 665 14 : : : cord-023134-y665agnh 665 15 2.9 2.9 CD cord-023134-y665agnh 665 16 % % NN cord-023134-y665agnh 665 17 ( ( -LRB- cord-023134-y665agnh 665 18 Group Group NNP cord-023134-y665agnh 665 19 1 1 CD cord-023134-y665agnh 665 20 ) ) -RRB- cord-023134-y665agnh 665 21 ; ; : cord-023134-y665agnh 665 22 2.8 2.8 CD cord-023134-y665agnh 665 23 % % NN cord-023134-y665agnh 665 24 ( ( -LRB- cord-023134-y665agnh 665 25 Group Group NNP cord-023134-y665agnh 665 26 2 2 CD cord-023134-y665agnh 665 27 ) ) -RRB- cord-023134-y665agnh 665 28 ; ; : cord-023134-y665agnh 665 29 3.2 3.2 CD cord-023134-y665agnh 665 30 % % NN cord-023134-y665agnh 665 31 ( ( -LRB- cord-023134-y665agnh 665 32 Group Group NNP cord-023134-y665agnh 665 33 3 3 CD cord-023134-y665agnh 665 34 ) ) -RRB- cord-023134-y665agnh 665 35 ; ; : cord-023134-y665agnh 665 36 6.9 6.9 CD cord-023134-y665agnh 665 37 % % NN cord-023134-y665agnh 665 38 ( ( -LRB- cord-023134-y665agnh 665 39 Group Group NNP cord-023134-y665agnh 665 40 4 4 CD cord-023134-y665agnh 665 41 ) ) -RRB- cord-023134-y665agnh 665 42 ; ; : cord-023134-y665agnh 665 43 and and CC cord-023134-y665agnh 665 44 4.3 4.3 CD cord-023134-y665agnh 665 45 % % NN cord-023134-y665agnh 665 46 ( ( -LRB- cord-023134-y665agnh 665 47 Group Group NNP cord-023134-y665agnh 665 48 5 5 CD cord-023134-y665agnh 665 49 ) ) -RRB- cord-023134-y665agnh 665 50 . . . cord-023134-y665agnh 666 1 In in IN cord-023134-y665agnh 666 2 conclusion conclusion NN cord-023134-y665agnh 666 3 , , , cord-023134-y665agnh 666 4 our -PRON- PRP$ cord-023134-y665agnh 666 5 results result NNS cord-023134-y665agnh 666 6 indicate indicate VBP cord-023134-y665agnh 666 7 that that IN cord-023134-y665agnh 666 8 hyperfunctional hyperfunctional JJ cord-023134-y665agnh 666 9 thyroid thyroid NN cord-023134-y665agnh 666 10 tissue tissue NN cord-023134-y665agnh 666 11 continues continue VBZ cord-023134-y665agnh 666 12 to to TO cord-023134-y665agnh 666 13 grow grow VB cord-023134-y665agnh 666 14 and and CC cord-023134-y665agnh 666 15 enlarge enlarge VB cord-023134-y665agnh 666 16 over over IN cord-023134-y665agnh 666 17 time time NN cord-023134-y665agnh 666 18 . . . cord-023134-y665agnh 667 1 Thyroid thyroid NN cord-023134-y665agnh 667 2 carcinoma carcinoma NN cord-023134-y665agnh 667 3 is be VBZ cord-023134-y665agnh 667 4 extremely extremely RB cord-023134-y665agnh 667 5 rare rare JJ cord-023134-y665agnh 667 6 in in IN cord-023134-y665agnh 667 7 cats cat NNS cord-023134-y665agnh 667 8 with with IN cord-023134-y665agnh 667 9 recently recently RB cord-023134-y665agnh 667 10 diagnosed diagnose VBN cord-023134-y665agnh 667 11 hyperthyroidism hyperthyroidism NN cord-023134-y665agnh 667 12 , , , cord-023134-y665agnh 667 13 but but CC cord-023134-y665agnh 667 14 the the DT cord-023134-y665agnh 667 15 prevalence prevalence NN cord-023134-y665agnh 667 16 increases increase VBZ cord-023134-y665agnh 667 17 dramatically dramatically RB cord-023134-y665agnh 667 18 over over IN cord-023134-y665agnh 667 19 time time NN cord-023134-y665agnh 667 20 , , , cord-023134-y665agnh 667 21 suggesting suggest VBG cord-023134-y665agnh 667 22 that that IN cord-023134-y665agnh 667 23 transformation transformation NN cord-023134-y665agnh 667 24 from from IN cord-023134-y665agnh 667 25 benign benign JJ cord-023134-y665agnh 667 26 disease disease NN cord-023134-y665agnh 667 27 is be VBZ cord-023134-y665agnh 667 28 common common JJ cord-023134-y665agnh 667 29 in in IN cord-023134-y665agnh 667 30 cats cat NNS cord-023134-y665agnh 667 31 controlled control VBN cord-023134-y665agnh 667 32 medically medically RB cord-023134-y665agnh 667 33 . . . cord-023134-y665agnh 668 1 Measurement measurement NN cord-023134-y665agnh 668 2 of of IN cord-023134-y665agnh 668 3 plasma plasma NN cord-023134-y665agnh 668 4 renin renin NN cord-023134-y665agnh 668 5 activity activity NN cord-023134-y665agnh 668 6 ( ( -LRB- cord-023134-y665agnh 668 7 PRA PRA NNP cord-023134-y665agnh 668 8 ) ) -RRB- cord-023134-y665agnh 668 9 is be VBZ cord-023134-y665agnh 668 10 considered consider VBN cord-023134-y665agnh 668 11 the the DT cord-023134-y665agnh 668 12 gold gold NN cord-023134-y665agnh 668 13 standard standard NN cord-023134-y665agnh 668 14 for for IN cord-023134-y665agnh 668 15 monitoring monitor VBG cord-023134-y665agnh 668 16 mineralocorticoid mineralocorticoid NN cord-023134-y665agnh 668 17 substitution substitution NN cord-023134-y665agnh 668 18 in in IN cord-023134-y665agnh 668 19 humans human NNS cord-023134-y665agnh 668 20 with with IN cord-023134-y665agnh 668 21 primary primary JJ cord-023134-y665agnh 668 22 hypoadrenocorticism hypoadrenocorticism NN cord-023134-y665agnh 668 23 ( ( -LRB- cord-023134-y665agnh 668 24 PH PH NNP cord-023134-y665agnh 668 25 ) ) -RRB- cord-023134-y665agnh 668 26 . . . cord-023134-y665agnh 669 1 It -PRON- PRP cord-023134-y665agnh 669 2 is be VBZ cord-023134-y665agnh 669 3 the the DT cord-023134-y665agnh 669 4 most most RBS cord-023134-y665agnh 669 5 sensitive sensitive JJ cord-023134-y665agnh 669 6 parameter parameter NN cord-023134-y665agnh 669 7 to to TO cord-023134-y665agnh 669 8 reflect reflect VB cord-023134-y665agnh 669 9 insufficient insufficient JJ cord-023134-y665agnh 669 10 as as RB cord-023134-y665agnh 669 11 well well RB cord-023134-y665agnh 669 12 as as IN cord-023134-y665agnh 669 13 inappropriate inappropriate JJ cord-023134-y665agnh 669 14 high high JJ cord-023134-y665agnh 669 15 replacement replacement NN cord-023134-y665agnh 669 16 . . . cord-023134-y665agnh 670 1 In in IN cord-023134-y665agnh 670 2 dogs dog NNS cord-023134-y665agnh 670 3 with with IN cord-023134-y665agnh 670 4 PH PH NNP cord-023134-y665agnh 670 5 mineralocorticoid mineralocorticoid NN cord-023134-y665agnh 670 6 substitution substitution NN cord-023134-y665agnh 670 7 is be VBZ cord-023134-y665agnh 670 8 currently currently RB cord-023134-y665agnh 670 9 monitored monitor VBN cord-023134-y665agnh 670 10 mainly mainly RB cord-023134-y665agnh 670 11 by by IN cord-023134-y665agnh 670 12 serum serum NN cord-023134-y665agnh 670 13 potassium potassium NN cord-023134-y665agnh 670 14 and and CC cord-023134-y665agnh 670 15 sodium sodium NN cord-023134-y665agnh 670 16 concentrations concentration NNS cord-023134-y665agnh 670 17 . . . cord-023134-y665agnh 671 1 The the DT cord-023134-y665agnh 671 2 role role NN cord-023134-y665agnh 671 3 of of IN cord-023134-y665agnh 671 4 PRA PRA NNP cord-023134-y665agnh 671 5 for for IN cord-023134-y665agnh 671 6 monitoring monitor VBG cord-023134-y665agnh 671 7 mineralocorticoid mineralocorticoid NN cord-023134-y665agnh 671 8 replacement replacement NN cord-023134-y665agnh 671 9 has have VBZ cord-023134-y665agnh 671 10 not not RB cord-023134-y665agnh 671 11 been be VBN cord-023134-y665agnh 671 12 investigated investigate VBN cord-023134-y665agnh 671 13 . . . cord-023134-y665agnh 672 1 The the DT cord-023134-y665agnh 672 2 aims aim NNS cord-023134-y665agnh 672 3 of of IN cord-023134-y665agnh 672 4 the the DT cord-023134-y665agnh 672 5 study study NN cord-023134-y665agnh 672 6 were be VBD cord-023134-y665agnh 672 7 to to TO cord-023134-y665agnh 672 8 measure measure VB cord-023134-y665agnh 672 9 and and CC cord-023134-y665agnh 672 10 compare compare VB cord-023134-y665agnh 672 11 PRA PRA NNP cord-023134-y665agnh 672 12 in in IN cord-023134-y665agnh 672 13 dogs dog NNS cord-023134-y665agnh 672 14 with with IN cord-023134-y665agnh 672 15 newly newly RB cord-023134-y665agnh 672 16 diagnosed diagnose VBN cord-023134-y665agnh 672 17 PH PH NNP cord-023134-y665agnh 672 18 and and CC cord-023134-y665agnh 672 19 dogs dog NNS cord-023134-y665agnh 672 20 with with IN cord-023134-y665agnh 672 21 diseases disease NNS cord-023134-y665agnh 672 22 mimicking mimic VBG cord-023134-y665agnh 672 23 PH PH NNP cord-023134-y665agnh 672 24 , , , cord-023134-y665agnh 672 25 and and CC cord-023134-y665agnh 672 26 to to TO cord-023134-y665agnh 672 27 evaluate evaluate VB cord-023134-y665agnh 672 28 PRA PRA NNP cord-023134-y665agnh 672 29 in in IN cord-023134-y665agnh 672 30 dogs dog NNS cord-023134-y665agnh 672 31 with with IN cord-023134-y665agnh 672 32 PH PH NNP cord-023134-y665agnh 672 33 treated treat VBN cord-023134-y665agnh 672 34 with with IN cord-023134-y665agnh 672 35 different different JJ cord-023134-y665agnh 672 36 mineralocorticoid mineralocorticoid NN cord-023134-y665agnh 672 37 substitution substitution NN cord-023134-y665agnh 672 38 regimes regime NNS cord-023134-y665agnh 672 39 . . . cord-023134-y665agnh 673 1 The the DT cord-023134-y665agnh 673 2 following follow VBG cord-023134-y665agnh 673 3 groups group NNS cord-023134-y665agnh 673 4 of of IN cord-023134-y665agnh 673 5 dogs dog NNS cord-023134-y665agnh 673 6 were be VBD cord-023134-y665agnh 673 7 included include VBN cord-023134-y665agnh 673 8 in in IN cord-023134-y665agnh 673 9 the the DT cord-023134-y665agnh 673 10 study study NN cord-023134-y665agnh 673 11 : : : cord-023134-y665agnh 673 12 5 5 CD cord-023134-y665agnh 673 13 dogs dog NNS cord-023134-y665agnh 673 14 with with IN cord-023134-y665agnh 673 15 newly newly RB cord-023134-y665agnh 673 16 diagnosed diagnose VBN cord-023134-y665agnh 673 17 PH PH NNP cord-023134-y665agnh 673 18 ( ( -LRB- cord-023134-y665agnh 673 19 group group NN cord-023134-y665agnh 673 20 1 1 CD cord-023134-y665agnh 673 21 ) ) -RRB- cord-023134-y665agnh 673 22 , , , cord-023134-y665agnh 673 23 10 10 CD cord-023134-y665agnh 673 24 dogs dog NNS cord-023134-y665agnh 673 25 that that WDT cord-023134-y665agnh 673 26 were be VBD cord-023134-y665agnh 673 27 already already RB cord-023134-y665agnh 673 28 treated treat VBN cord-023134-y665agnh 673 29 for for IN cord-023134-y665agnh 673 30 PH PH NNP cord-023134-y665agnh 673 31 ( ( -LRB- cord-023134-y665agnh 673 32 group group NN cord-023134-y665agnh 673 33 2 2 CD cord-023134-y665agnh 673 34 ) ) -RRB- cord-023134-y665agnh 673 35 , , , cord-023134-y665agnh 673 36 and and CC cord-023134-y665agnh 673 37 10 10 CD cord-023134-y665agnh 673 38 dogs dog NNS cord-023134-y665agnh 673 39 with with IN cord-023134-y665agnh 673 40 diseases disease NNS cord-023134-y665agnh 673 41 mimicking mimic VBG cord-023134-y665agnh 673 42 PH PH NNP cord-023134-y665agnh 673 43 ( ( -LRB- cord-023134-y665agnh 673 44 group group NN cord-023134-y665agnh 673 45 3 3 CD cord-023134-y665agnh 673 46 ) ) -RRB- cord-023134-y665agnh 673 47 . . . cord-023134-y665agnh 674 1 In in IN cord-023134-y665agnh 674 2 group group NN cord-023134-y665agnh 674 3 1 1 CD cord-023134-y665agnh 674 4 PRA PRA NNP cord-023134-y665agnh 674 5 was be VBD cord-023134-y665agnh 674 6 measured measure VBN cord-023134-y665agnh 674 7 before before IN cord-023134-y665agnh 674 8 treatment treatment NN cord-023134-y665agnh 674 9 and and CC cord-023134-y665agnh 674 10 1 1 CD cord-023134-y665agnh 674 11 - - SYM cord-023134-y665agnh 674 12 3 3 CD cord-023134-y665agnh 674 13 weeks week NNS cord-023134-y665agnh 674 14 , , , cord-023134-y665agnh 674 15 4 4 CD cord-023134-y665agnh 674 16 - - SYM cord-023134-y665agnh 674 17 6 6 CD cord-023134-y665agnh 674 18 weeks week NNS cord-023134-y665agnh 674 19 , , , cord-023134-y665agnh 674 20 and and CC cord-023134-y665agnh 674 21 7 7 CD cord-023134-y665agnh 674 22 - - SYM cord-023134-y665agnh 674 23 10 10 CD cord-023134-y665agnh 674 24 weeks week NNS cord-023134-y665agnh 674 25 after after IN cord-023134-y665agnh 674 26 start start NN cord-023134-y665agnh 674 27 of of IN cord-023134-y665agnh 674 28 therapy therapy NN cord-023134-y665agnh 674 29 . . . cord-023134-y665agnh 675 1 In in IN cord-023134-y665agnh 675 2 group group NN cord-023134-y665agnh 675 3 2 2 CD cord-023134-y665agnh 675 4 PRA PRA NNP cord-023134-y665agnh 675 5 was be VBD cord-023134-y665agnh 675 6 measured measure VBN cord-023134-y665agnh 675 7 at at IN cord-023134-y665agnh 675 8 least least RBS cord-023134-y665agnh 675 9 twice twice PDT cord-023134-y665agnh 675 10 every every DT cord-023134-y665agnh 675 11 1 1 CD cord-023134-y665agnh 675 12 to to TO cord-023134-y665agnh 675 13 6 6 CD cord-023134-y665agnh 675 14 months month NNS cord-023134-y665agnh 675 15 . . . cord-023134-y665agnh 676 1 In in IN cord-023134-y665agnh 676 2 group group NN cord-023134-y665agnh 676 3 3 3 CD cord-023134-y665agnh 676 4 PRA PRA NNP cord-023134-y665agnh 676 5 was be VBD cord-023134-y665agnh 676 6 measured measure VBN cord-023134-y665agnh 676 7 once once RB cord-023134-y665agnh 676 8 at at IN cord-023134-y665agnh 676 9 initial initial JJ cord-023134-y665agnh 676 10 presentation presentation NN cord-023134-y665agnh 676 11 . . . cord-023134-y665agnh 677 1 Three three CD cord-023134-y665agnh 677 2 dogs dog NNS cord-023134-y665agnh 677 3 of of IN cord-023134-y665agnh 677 4 group group NN cord-023134-y665agnh 677 5 1 1 CD cord-023134-y665agnh 677 6 and and CC cord-023134-y665agnh 677 7 7 7 CD cord-023134-y665agnh 677 8 dogs dog NNS cord-023134-y665agnh 677 9 of of IN cord-023134-y665agnh 677 10 group group NN cord-023134-y665agnh 677 11 2 2 CD cord-023134-y665agnh 677 12 were be VBD cord-023134-y665agnh 677 13 treated treat VBN cord-023134-y665agnh 677 14 with with IN cord-023134-y665agnh 677 15 fludrocortisone fludrocortisone NNP cord-023134-y665agnh 677 16 ( ( -LRB- cord-023134-y665agnh 677 17 Florinef Florinef NNP cord-023134-y665agnh 677 18 ® ® POS cord-023134-y665agnh 677 19 , , , cord-023134-y665agnh 677 20 Bristol Bristol NNP cord-023134-y665agnh 677 21 - - HYPH cord-023134-y665agnh 677 22 Myers Myers NNP cord-023134-y665agnh 677 23 Squibb Squibb NNP cord-023134-y665agnh 677 24 ) ) -RRB- cord-023134-y665agnh 677 25 . . . cord-023134-y665agnh 678 1 Two two CD cord-023134-y665agnh 678 2 dogs dog NNS cord-023134-y665agnh 678 3 of of IN cord-023134-y665agnh 678 4 group group NN cord-023134-y665agnh 678 5 1 1 CD cord-023134-y665agnh 678 6 and and CC cord-023134-y665agnh 678 7 3 3 CD cord-023134-y665agnh 678 8 dogs dog NNS cord-023134-y665agnh 678 9 of of IN cord-023134-y665agnh 678 10 group group NN cord-023134-y665agnh 678 11 2 2 CD cord-023134-y665agnh 678 12 were be VBD cord-023134-y665agnh 678 13 treated treat VBN cord-023134-y665agnh 678 14 with with IN cord-023134-y665agnh 678 15 DOCP DOCP NNP cord-023134-y665agnh 678 16 ( ( -LRB- cord-023134-y665agnh 678 17 Percorten Percorten NNP cord-023134-y665agnh 679 1 ® ® LS cord-023134-y665agnh 679 2 -V -v RBS cord-023134-y665agnh 679 3 , , , cord-023134-y665agnh 679 4 Novartis Novartis NNP cord-023134-y665agnh 679 5 ) ) -RRB- cord-023134-y665agnh 679 6 . . . cord-023134-y665agnh 680 1 PRA PRA NNP cord-023134-y665agnh 680 2 was be VBD cord-023134-y665agnh 680 3 measured measure VBN cord-023134-y665agnh 680 4 with with IN cord-023134-y665agnh 680 5 an an DT cord-023134-y665agnh 680 6 enzymatic enzymatic JJ cord-023134-y665agnh 680 7 assay assay NN cord-023134-y665agnh 680 8 via via IN cord-023134-y665agnh 680 9 trapping trapping NN cord-023134-y665agnh 680 10 of of IN cord-023134-y665agnh 680 11 angiotensin angiotensin NN cord-023134-y665agnh 681 1 I -PRON- PRP cord-023134-y665agnh 681 2 in in IN cord-023134-y665agnh 681 3 the the DT cord-023134-y665agnh 681 4 Service Service NNP cord-023134-y665agnh 681 5 d'Angiologie d'Angiologie NNP cord-023134-y665agnh 681 6 , , , cord-023134-y665agnh 681 7 CHUV CHUV NNP cord-023134-y665agnh 681 8 - - HYPH cord-023134-y665agnh 681 9 NES NES NNP cord-023134-y665agnh 681 10 , , , cord-023134-y665agnh 681 11 Lausanne Lausanne NNP cord-023134-y665agnh 681 12 . . . cord-023134-y665agnh 682 1 Results result NNS cord-023134-y665agnh 682 2 were be VBD cord-023134-y665agnh 682 3 analysed analyse VBN cord-023134-y665agnh 682 4 by by IN cord-023134-y665agnh 682 5 means mean NNS cord-023134-y665agnh 682 6 of of IN cord-023134-y665agnh 682 7 non non JJ cord-023134-y665agnh 682 8 - - JJ cord-023134-y665agnh 682 9 parametric parametric JJ cord-023134-y665agnh 682 10 methods method NNS cord-023134-y665agnh 682 11 ( ( -LRB- cord-023134-y665agnh 682 12 p p NN cord-023134-y665agnh 682 13 < < XX cord-023134-y665agnh 682 14 0.05).PRA 0.05).pra CD cord-023134-y665agnh 682 15 before before IN cord-023134-y665agnh 682 16 treatment treatment NN cord-023134-y665agnh 682 17 was be VBD cord-023134-y665agnh 682 18 significantly significantly RB cord-023134-y665agnh 682 19 higher high JJR cord-023134-y665agnh 682 20 in in IN cord-023134-y665agnh 682 21 group group NN cord-023134-y665agnh 682 22 1 1 CD cord-023134-y665agnh 682 23 ( ( -LRB- cord-023134-y665agnh 682 24 1.6 1.6 CD cord-023134-y665agnh 682 25 - - SYM cord-023134-y665agnh 682 26 36.0 36.0 CD cord-023134-y665agnh 682 27 ng/ ng/ NNP cord-023134-y665agnh 682 28 l l NNP cord-023134-y665agnh 682 29 / / SYM cord-023134-y665agnh 682 30 h h NNP cord-023134-y665agnh 682 31 , , , cord-023134-y665agnh 682 32 median median JJ cord-023134-y665agnh 682 33 22.5 22.5 CD cord-023134-y665agnh 682 34 ) ) -RRB- cord-023134-y665agnh 682 35 than than IN cord-023134-y665agnh 682 36 in in IN cord-023134-y665agnh 682 37 group group NN cord-023134-y665agnh 682 38 3 3 CD cord-023134-y665agnh 682 39 ( ( -LRB- cord-023134-y665agnh 682 40 0.5 0.5 CD cord-023134-y665agnh 682 41 - - SYM cord-023134-y665agnh 682 42 2.8 2.8 CD cord-023134-y665agnh 682 43 ng ng NN cord-023134-y665agnh 682 44 / / SYM cord-023134-y665agnh 682 45 l l NN cord-023134-y665agnh 682 46 / / SYM cord-023134-y665agnh 682 47 h h NNP cord-023134-y665agnh 682 48 , , , cord-023134-y665agnh 682 49 median median NN cord-023134-y665agnh 682 50 1.0 1.0 CD cord-023134-y665agnh 682 51 ) ) -RRB- cord-023134-y665agnh 682 52 . . . cord-023134-y665agnh 683 1 Average average JJ cord-023134-y665agnh 683 2 PRA PRA NNP cord-023134-y665agnh 683 3 during during IN cord-023134-y665agnh 683 4 therapy therapy NN cord-023134-y665agnh 683 5 ranged range VBD cord-023134-y665agnh 683 6 from from IN cord-023134-y665agnh 683 7 0.47 0.47 CD cord-023134-y665agnh 683 8 to to IN cord-023134-y665agnh 683 9 29 29 CD cord-023134-y665agnh 683 10 ng ng NN cord-023134-y665agnh 683 11 / / SYM cord-023134-y665agnh 683 12 ml ml NN cord-023134-y665agnh 683 13 / / SYM cord-023134-y665agnh 683 14 h h NNP cord-023134-y665agnh 683 15 ( ( -LRB- cord-023134-y665agnh 683 16 median median JJ cord-023134-y665agnh 683 17 8) 8) NN cord-023134-y665agnh 683 18 . . . cord-023134-y665agnh 684 1 PRA PRA NNP cord-023134-y665agnh 684 2 did do VBD cord-023134-y665agnh 684 3 not not RB cord-023134-y665agnh 684 4 decrease decrease VB cord-023134-y665agnh 684 5 significantly significantly RB cord-023134-y665agnh 684 6 in in IN cord-023134-y665agnh 684 7 dogs dog NNS cord-023134-y665agnh 684 8 treated treat VBN cord-023134-y665agnh 684 9 with with IN cord-023134-y665agnh 684 10 fludrocortisone fludrocortisone NNP cord-023134-y665agnh 684 11 . . . cord-023134-y665agnh 685 1 PRA PRA NNP cord-023134-y665agnh 685 2 of of IN cord-023134-y665agnh 685 3 dogs dog NNS cord-023134-y665agnh 685 4 treated treat VBN cord-023134-y665agnh 685 5 with with IN cord-023134-y665agnh 685 6 DOCP DOCP NNP cord-023134-y665agnh 685 7 ( ( -LRB- cord-023134-y665agnh 685 8 0.11 0.11 CD cord-023134-y665agnh 685 9 - - SYM cord-023134-y665agnh 685 10 10.61 10.61 CD cord-023134-y665agnh 685 11 ng ng NN cord-023134-y665agnh 685 12 / / SYM cord-023134-y665agnh 685 13 ml ml NNP cord-023134-y665agnh 685 14 / / SYM cord-023134-y665agnh 685 15 h h NNP cord-023134-y665agnh 685 16 , , , cord-023134-y665agnh 685 17 median median NN cord-023134-y665agnh 685 18 5 5 CD cord-023134-y665agnh 685 19 ) ) -RRB- cord-023134-y665agnh 685 20 was be VBD cord-023134-y665agnh 685 21 significantly significantly RB cord-023134-y665agnh 685 22 lower low JJR cord-023134-y665agnh 685 23 compared compare VBN cord-023134-y665agnh 685 24 to to IN cord-023134-y665agnh 685 25 dogs dog NNS cord-023134-y665agnh 685 26 treated treat VBN cord-023134-y665agnh 685 27 with with IN cord-023134-y665agnh 685 28 fludrocortisone fludrocortisone NNP cord-023134-y665agnh 685 29 ( ( -LRB- cord-023134-y665agnh 685 30 0.47 0.47 CD cord-023134-y665agnh 685 31 - - SYM cord-023134-y665agnh 685 32 38.3 38.3 CD cord-023134-y665agnh 685 33 ng ng NNP cord-023134-y665agnh 685 34 / / SYM cord-023134-y665agnh 685 35 ml ml NNP cord-023134-y665agnh 685 36 / / SYM cord-023134-y665agnh 685 37 h h NNP cord-023134-y665agnh 685 38 , , , cord-023134-y665agnh 685 39 median median JJ cord-023134-y665agnh 685 40 16.5 16.5 CD cord-023134-y665agnh 685 41 ) ) -RRB- cord-023134-y665agnh 685 42 . . . cord-023134-y665agnh 686 1 All all DT cord-023134-y665agnh 686 2 dogs dog NNS cord-023134-y665agnh 686 3 treated treat VBN cord-023134-y665agnh 686 4 with with IN cord-023134-y665agnh 686 5 DOCP DOCP NNP cord-023134-y665agnh 686 6 had have VBD cord-023134-y665agnh 686 7 normal normal JJ cord-023134-y665agnh 686 8 serum serum NN cord-023134-y665agnh 686 9 sodium sodium NN cord-023134-y665agnh 686 10 and and CC cord-023134-y665agnh 686 11 potassium potassium NN cord-023134-y665agnh 686 12 at at RB cord-023134-y665agnh 686 13 all all RB cord-023134-y665agnh 686 14 re re NNS cord-023134-y665agnh 686 15 - - NNS cord-023134-y665agnh 686 16 checks check NNS cord-023134-y665agnh 686 17 , , , cord-023134-y665agnh 686 18 whereas whereas IN cord-023134-y665agnh 686 19 dogs dog NNS cord-023134-y665agnh 686 20 treated treat VBN cord-023134-y665agnh 686 21 with with IN cord-023134-y665agnh 686 22 fludrocortisone fludrocortisone NNP cord-023134-y665agnh 686 23 had have VBD cord-023134-y665agnh 686 24 mild mild JJ cord-023134-y665agnh 686 25 to to IN cord-023134-y665agnh 686 26 severe severe JJ cord-023134-y665agnh 686 27 electrolyte electrolyte JJ cord-023134-y665agnh 686 28 abnormalities abnormality NNS cord-023134-y665agnh 686 29 at at IN cord-023134-y665agnh 686 30 several several JJ cord-023134-y665agnh 686 31 occasions occasion NNS cord-023134-y665agnh 686 32 . . . cord-023134-y665agnh 687 1 There there EX cord-023134-y665agnh 687 2 was be VBD cord-023134-y665agnh 687 3 a a DT cord-023134-y665agnh 687 4 weak weak JJ cord-023134-y665agnh 687 5 correlation correlation NN cord-023134-y665agnh 687 6 between between IN cord-023134-y665agnh 687 7 PRA PRA NNP cord-023134-y665agnh 687 8 and and CC cord-023134-y665agnh 687 9 serum serum NN cord-023134-y665agnh 687 10 potassium potassium NN cord-023134-y665agnh 687 11 . . . cord-023134-y665agnh 688 1 Measurement measurement NN cord-023134-y665agnh 688 2 of of IN cord-023134-y665agnh 688 3 PRA PRA NNP cord-023134-y665agnh 688 4 is be VBZ cord-023134-y665agnh 688 5 a a DT cord-023134-y665agnh 688 6 promising promising JJ cord-023134-y665agnh 688 7 tool tool NN cord-023134-y665agnh 688 8 for for IN cord-023134-y665agnh 688 9 monitoring monitor VBG cord-023134-y665agnh 688 10 mineralocorticoid mineralocorticoid NN cord-023134-y665agnh 688 11 substitution substitution NN cord-023134-y665agnh 688 12 in in IN cord-023134-y665agnh 688 13 dogs dog NNS cord-023134-y665agnh 688 14 with with IN cord-023134-y665agnh 688 15 PH PH NNP cord-023134-y665agnh 688 16 . . . cord-023134-y665agnh 689 1 According accord VBG cord-023134-y665agnh 689 2 to to IN cord-023134-y665agnh 689 3 our -PRON- PRP$ cord-023134-y665agnh 689 4 preliminary preliminary JJ cord-023134-y665agnh 689 5 results result NNS cord-023134-y665agnh 689 6 DOCP DOCP NNP cord-023134-y665agnh 689 7 is be VBZ cord-023134-y665agnh 689 8 superior superior JJ cord-023134-y665agnh 689 9 to to IN cord-023134-y665agnh 689 10 fludrocortisone fludrocortisone NNP cord-023134-y665agnh 689 11 for for IN cord-023134-y665agnh 689 12 mineralocorticoid mineralocorticoid NN cord-023134-y665agnh 689 13 replacement replacement NN cord-023134-y665agnh 689 14 . . . cord-023134-y665agnh 690 1 Phenobarbital phenobarbital NN cord-023134-y665agnh 690 2 is be VBZ cord-023134-y665agnh 690 3 widely widely RB cord-023134-y665agnh 690 4 used use VBN cord-023134-y665agnh 690 5 to to TO cord-023134-y665agnh 690 6 control control VB cord-023134-y665agnh 690 7 epilepsy epilepsy NN cord-023134-y665agnh 690 8 in in IN cord-023134-y665agnh 690 9 dogs dog NNS cord-023134-y665agnh 690 10 . . . cord-023134-y665agnh 691 1 Use use NN cord-023134-y665agnh 691 2 of of IN cord-023134-y665agnh 691 3 phenobarbital phenobarbital NN cord-023134-y665agnh 691 4 induces induce VBZ cord-023134-y665agnh 691 5 hepatic hepatic JJ cord-023134-y665agnh 691 6 enzyme enzyme NN cord-023134-y665agnh 691 7 activity activity NN cord-023134-y665agnh 691 8 , , , cord-023134-y665agnh 691 9 and and CC cord-023134-y665agnh 691 10 may may MD cord-023134-y665agnh 691 11 decrease decrease VB cord-023134-y665agnh 691 12 serum serum NN cord-023134-y665agnh 691 13 total total JJ cord-023134-y665agnh 691 14 and and CC cord-023134-y665agnh 691 15 free free JJ cord-023134-y665agnh 691 16 thyroxine thyroxine NN cord-023134-y665agnh 691 17 ( ( -LRB- cord-023134-y665agnh 691 18 tT4 tT4 NNP cord-023134-y665agnh 691 19 and and CC cord-023134-y665agnh 691 20 fT4 ft4 NN cord-023134-y665agnh 691 21 ) ) -RRB- cord-023134-y665agnh 691 22 , , , cord-023134-y665agnh 691 23 with with IN cord-023134-y665agnh 691 24 the the DT cord-023134-y665agnh 691 25 exact exact JJ cord-023134-y665agnh 691 26 mechanisms mechanism NNS cord-023134-y665agnh 691 27 and and CC cord-023134-y665agnh 691 28 prevalence prevalence NN cord-023134-y665agnh 691 29 of of IN cord-023134-y665agnh 691 30 this this DT cord-023134-y665agnh 691 31 phenomenon phenomenon NN cord-023134-y665agnh 691 32 being be VBG cord-023134-y665agnh 691 33 unknown unknown JJ cord-023134-y665agnh 691 34 . . . cord-023134-y665agnh 692 1 The the DT cord-023134-y665agnh 692 2 aim aim NN cord-023134-y665agnh 692 3 of of IN cord-023134-y665agnh 692 4 the the DT cord-023134-y665agnh 692 5 present present JJ cord-023134-y665agnh 692 6 retrospective retrospective JJ cord-023134-y665agnh 692 7 study study NN cord-023134-y665agnh 692 8 therefore therefore RB cord-023134-y665agnh 692 9 was be VBD cord-023134-y665agnh 692 10 to to TO cord-023134-y665agnh 692 11 investigate investigate VB cord-023134-y665agnh 692 12 how how WRB cord-023134-y665agnh 692 13 many many JJ cord-023134-y665agnh 692 14 dogs dog NNS cord-023134-y665agnh 692 15 treated treat VBN cord-023134-y665agnh 692 16 with with IN cord-023134-y665agnh 692 17 phenobarbital phenobarbital NN cord-023134-y665agnh 692 18 show show VBP cord-023134-y665agnh 692 19 a a DT cord-023134-y665agnh 692 20 decrease decrease NN cord-023134-y665agnh 692 21 in in IN cord-023134-y665agnh 692 22 thyroid thyroid JJ cord-023134-y665agnh 692 23 hormones hormone NNS cord-023134-y665agnh 692 24 and and CC cord-023134-y665agnh 692 25 to to TO cord-023134-y665agnh 692 26 give give VB cord-023134-y665agnh 692 27 insight insight NN cord-023134-y665agnh 692 28 into into IN cord-023134-y665agnh 692 29 potential potential JJ cord-023134-y665agnh 692 30 mechanisms mechanism NNS cord-023134-y665agnh 692 31 . . . cord-023134-y665agnh 693 1 For for IN cord-023134-y665agnh 693 2 this this DT cord-023134-y665agnh 693 3 , , , cord-023134-y665agnh 693 4 tT4 tT4 NNP cord-023134-y665agnh 693 5 , , , cord-023134-y665agnh 693 6 fT4 fT4 VBN cord-023134-y665agnh 693 7 , , , cord-023134-y665agnh 693 8 and and CC cord-023134-y665agnh 693 9 TSH TSH NNP cord-023134-y665agnh 693 10 were be VBD cord-023134-y665agnh 693 11 measured measure VBN cord-023134-y665agnh 693 12 in in IN cord-023134-y665agnh 693 13 746 746 CD cord-023134-y665agnh 693 14 canine canine JJ cord-023134-y665agnh 693 15 serum serum NN cord-023134-y665agnh 693 16 samples sample NNS cord-023134-y665agnh 693 17 submitted submit VBN cord-023134-y665agnh 693 18 for for IN cord-023134-y665agnh 693 19 assessment assessment NN cord-023134-y665agnh 693 20 of of IN cord-023134-y665agnh 693 21 therapeutic therapeutic JJ cord-023134-y665agnh 693 22 concentrations concentration NNS cord-023134-y665agnh 693 23 of of IN cord-023134-y665agnh 693 24 phenobarbital phenobarbital NN cord-023134-y665agnh 693 25 . . . cord-023134-y665agnh 694 1 In in IN cord-023134-y665agnh 694 2 a a DT cord-023134-y665agnh 694 3 smaller small JJR cord-023134-y665agnh 694 4 subset subset JJ cord-023134-y665agnh 694 5 of of IN cord-023134-y665agnh 694 6 dogs dog NNS cord-023134-y665agnh 694 7 , , , cord-023134-y665agnh 694 8 albumin albumin NN cord-023134-y665agnh 694 9 , , , cord-023134-y665agnh 694 10 total total JJ cord-023134-y665agnh 694 11 protein protein NN cord-023134-y665agnh 694 12 , , , cord-023134-y665agnh 694 13 and and CC cord-023134-y665agnh 694 14 transthyretin transthyretin NNP cord-023134-y665agnh 694 15 ( ( -LRB- cord-023134-y665agnh 694 16 TTR TTR NNP cord-023134-y665agnh 694 17 ) ) -RRB- cord-023134-y665agnh 694 18 were be VBD cord-023134-y665agnh 694 19 also also RB cord-023134-y665agnh 694 20 measured measure VBN cord-023134-y665agnh 694 21 at at IN cord-023134-y665agnh 694 22 the the DT cord-023134-y665agnh 694 23 Diagnostic Diagnostic NNP cord-023134-y665agnh 694 24 Center Center NNP cord-023134-y665agnh 694 25 for for IN cord-023134-y665agnh 694 26 Population Population NNP cord-023134-y665agnh 694 27 and and CC cord-023134-y665agnh 694 28 Animal Animal NNP cord-023134-y665agnh 694 29 Health Health NNP cord-023134-y665agnh 694 30 , , , cord-023134-y665agnh 694 31 Michigan Michigan NNP cord-023134-y665agnh 694 32 , , , cord-023134-y665agnh 694 33 USA.According usa.accorde VBG cord-023134-y665agnh 694 34 to to IN cord-023134-y665agnh 694 35 thyroid thyroid NN cord-023134-y665agnh 694 36 results result NNS cord-023134-y665agnh 694 37 , , , cord-023134-y665agnh 694 38 dogs dog NNS cord-023134-y665agnh 694 39 were be VBD cord-023134-y665agnh 694 40 classified classify VBN cord-023134-y665agnh 694 41 as as IN cord-023134-y665agnh 694 42 ' ' `` cord-023134-y665agnh 694 43 non non JJ cord-023134-y665agnh 694 44 thyroidal thyroidal JJ cord-023134-y665agnh 694 45 illness illness NN cord-023134-y665agnh 694 46 ' ' '' cord-023134-y665agnh 694 47 ( ( -LRB- cord-023134-y665agnh 694 48 NTI NTI NNP cord-023134-y665agnh 694 49 ) ) -RRB- cord-023134-y665agnh 694 50 ( ( -LRB- cord-023134-y665agnh 694 51 tT4 tT4 NNP cord-023134-y665agnh 694 52 < < XX cord-023134-y665agnh 694 53 11 11 CD cord-023134-y665agnh 694 54 nmol nmol NNP cord-023134-y665agnh 694 55 / / SYM cord-023134-y665agnh 694 56 L L NNP cord-023134-y665agnh 694 57 , , , cord-023134-y665agnh 694 58 fT4 fT4 VBN cord-023134-y665agnh 694 59 ! ! . cord-023134-y665agnh 694 60 6 6 CD cord-023134-y665agnh 694 61 pmol pmol NN cord-023134-y665agnh 694 62 / / SYM cord-023134-y665agnh 694 63 L L NNP cord-023134-y665agnh 694 64 , , , cord-023134-y665agnh 694 65 TSH TSH NNP cord-023134-y665agnh 694 66 0.48 0.48 CD cord-023134-y665agnh 694 67 ng ng NNP cord-023134-y665agnh 694 68 / / SYM cord-023134-y665agnh 694 69 mL mL NNP cord-023134-y665agnh 694 70 ) ) -RRB- cord-023134-y665agnh 694 71 ; ; : cord-023134-y665agnh 694 72 ' ' `` cord-023134-y665agnh 694 73 equivocal equivocal JJ cord-023134-y665agnh 694 74 ' ' '' cord-023134-y665agnh 694 75 ( ( -LRB- cord-023134-y665agnh 694 76 E e NN cord-023134-y665agnh 694 77 ) ) -RRB- cord-023134-y665agnh 694 78 ( ( -LRB- cord-023134-y665agnh 694 79 tT4 tT4 NNP cord-023134-y665agnh 694 80 < < XX cord-023134-y665agnh 694 81 11 11 CD cord-023134-y665agnh 694 82 nmol nmol NNP cord-023134-y665agnh 694 83 / / SYM cord-023134-y665agnh 694 84 L L NNP cord-023134-y665agnh 694 85 , , , cord-023134-y665agnh 694 86 fT4 fT4 VBD cord-023134-y665agnh 694 87 < < $ cord-023134-y665agnh 694 88 6 6 CD cord-023134-y665agnh 694 89 pmol pmol NNP cord-023134-y665agnh 694 90 / / SYM cord-023134-y665agnh 694 91 L L NNP cord-023134-y665agnh 694 92 , , , cord-023134-y665agnh 694 93 TSH TSH NNP cord-023134-y665agnh 694 94 0.48 0.48 CD cord-023134-y665agnh 694 95 ng ng NNP cord-023134-y665agnh 694 96 / / SYM cord-023134-y665agnh 694 97 mL mL NNP cord-023134-y665agnh 694 98 ) ) -RRB- cord-023134-y665agnh 694 99 ; ; : cord-023134-y665agnh 694 100 ' ' `` cord-023134-y665agnh 694 101 hypothyroid hypothyroid JJ cord-023134-y665agnh 694 102 ' ' '' cord-023134-y665agnh 694 103 ( ( -LRB- cord-023134-y665agnh 694 104 HT HT NNP cord-023134-y665agnh 694 105 ) ) -RRB- cord-023134-y665agnh 694 106 ( ( -LRB- cord-023134-y665agnh 694 107 pattern pattern NN cord-023134-y665agnh 694 108 of of IN cord-023134-y665agnh 694 109 low low JJ cord-023134-y665agnh 694 110 tT4 tt4 NN cord-023134-y665agnh 694 111 and and CC cord-023134-y665agnh 694 112 fT4 fT4 VBN cord-023134-y665agnh 694 113 , , , cord-023134-y665agnh 694 114 TSH TSH NNP cord-023134-y665agnh 694 115 > > XX cord-023134-y665agnh 694 116 0.48 0.48 CD cord-023134-y665agnh 694 117 ng/ ng/ NN cord-023134-y665agnh 694 118 mL mL NNP cord-023134-y665agnh 694 119 ) ) -RRB- cord-023134-y665agnh 694 120 ; ; : cord-023134-y665agnh 694 121 and and CC cord-023134-y665agnh 694 122 ' ' `` cord-023134-y665agnh 694 123 normal normal JJ cord-023134-y665agnh 694 124 ' ' '' cord-023134-y665agnh 694 125 ( ( -LRB- cord-023134-y665agnh 694 126 N n NN cord-023134-y665agnh 694 127 ) ) -RRB- cord-023134-y665agnh 694 128 ( ( -LRB- cord-023134-y665agnh 694 129 tT4 tT4 NNP cord-023134-y665agnh 694 130 ! ! . cord-023134-y665agnh 695 1 11nmol 11nmol NNP cord-023134-y665agnh 695 2 / / SYM cord-023134-y665agnh 695 3 L l NN cord-023134-y665agnh 695 4 ; ; : cord-023134-y665agnh 695 5 fT4 fT4 VBN cord-023134-y665agnh 695 6 ! ! . cord-023134-y665agnh 695 7 6 6 CD cord-023134-y665agnh 695 8 pmol pmol NN cord-023134-y665agnh 695 9 / / SYM cord-023134-y665agnh 695 10 L L NNP cord-023134-y665agnh 695 11 and and CC cord-023134-y665agnh 695 12 TSH TSH NNP cord-023134-y665agnh 695 13 0.48 0.48 CD cord-023134-y665agnh 695 14 ng ng NNP cord-023134-y665agnh 695 15 / / SYM cord-023134-y665agnh 695 16 mL).Forty mL).Forty NNP cord-023134-y665agnh 695 17 - - HYPH cord-023134-y665agnh 695 18 five five CD cord-023134-y665agnh 695 19 dogs dog NNS cord-023134-y665agnh 695 20 were be VBD cord-023134-y665agnh 695 21 classified classify VBN cord-023134-y665agnh 695 22 as as IN cord-023134-y665agnh 695 23 NTI NTI NNP cord-023134-y665agnh 695 24 ( ( -LRB- cord-023134-y665agnh 695 25 6.0 6.0 CD cord-023134-y665agnh 695 26 % % NN cord-023134-y665agnh 695 27 ) ) -RRB- cord-023134-y665agnh 695 28 , , , cord-023134-y665agnh 695 29 52 52 CD cord-023134-y665agnh 695 30 dogs dog NNS cord-023134-y665agnh 695 31 were be VBD cord-023134-y665agnh 695 32 classified classify VBN cord-023134-y665agnh 695 33 as as IN cord-023134-y665agnh 695 34 E E NNP cord-023134-y665agnh 695 35 ( ( -LRB- cord-023134-y665agnh 695 36 7.0 7.0 CD cord-023134-y665agnh 695 37 % % NN cord-023134-y665agnh 695 38 ) ) -RRB- cord-023134-y665agnh 695 39 , , , cord-023134-y665agnh 695 40 38 38 CD cord-023134-y665agnh 695 41 were be VBD cord-023134-y665agnh 695 42 classified classify VBN cord-023134-y665agnh 695 43 as as IN cord-023134-y665agnh 695 44 HT HT NNP cord-023134-y665agnh 695 45 ( ( -LRB- cord-023134-y665agnh 695 46 4.7 4.7 CD cord-023134-y665agnh 695 47 % % NN cord-023134-y665agnh 695 48 ) ) -RRB- cord-023134-y665agnh 695 49 , , , cord-023134-y665agnh 695 50 and and CC cord-023134-y665agnh 695 51 552 552 CD cord-023134-y665agnh 695 52 as as IN cord-023134-y665agnh 695 53 N n CD cord-023134-y665agnh 695 54 ( ( -LRB- cord-023134-y665agnh 695 55 74 74 CD cord-023134-y665agnh 695 56 % % NN cord-023134-y665agnh 695 57 ) ) -RRB- cord-023134-y665agnh 695 58 ; ; : cord-023134-y665agnh 695 59 52 52 CD cord-023134-y665agnh 695 60 dogs dog NNS cord-023134-y665agnh 695 61 did do VBD cord-023134-y665agnh 695 62 not not RB cord-023134-y665agnh 695 63 fit fit VB cord-023134-y665agnh 695 64 in in IN cord-023134-y665agnh 695 65 any any DT cord-023134-y665agnh 695 66 defined define VBN cord-023134-y665agnh 695 67 category category NN cord-023134-y665agnh 695 68 . . . cord-023134-y665agnh 696 1 There there EX cord-023134-y665agnh 696 2 was be VBD cord-023134-y665agnh 696 3 no no DT cord-023134-y665agnh 696 4 statistically statistically RB cord-023134-y665agnh 696 5 significant significant JJ cord-023134-y665agnh 696 6 difference difference NN cord-023134-y665agnh 696 7 in in IN cord-023134-y665agnh 696 8 mean mean JJ cord-023134-y665agnh 696 9 phenobarbital phenobarbital JJ cord-023134-y665agnh 696 10 concentrations concentration NNS cord-023134-y665agnh 696 11 between between IN cord-023134-y665agnh 696 12 NTI NTI NNP cord-023134-y665agnh 696 13 , , , cord-023134-y665agnh 696 14 E E NNP cord-023134-y665agnh 696 15 , , , cord-023134-y665agnh 696 16 HT HT NNP cord-023134-y665agnh 696 17 , , , cord-023134-y665agnh 696 18 and and CC cord-023134-y665agnh 697 1 N n NN cord-023134-y665agnh 697 2 ( ( -LRB- cord-023134-y665agnh 697 3 94.2 94.2 CD cord-023134-y665agnh 697 4 ± ± CD cord-023134-y665agnh 697 5 35.1 35.1 CD cord-023134-y665agnh 697 6 , , , cord-023134-y665agnh 697 7 100.6 100.6 CD cord-023134-y665agnh 697 8 ± ± CD cord-023134-y665agnh 697 9 43.9 43.9 CD cord-023134-y665agnh 697 10 , , , cord-023134-y665agnh 697 11 86.8 86.8 CD cord-023134-y665agnh 697 12 ± ± CD cord-023134-y665agnh 697 13 29.4 29.4 CD cord-023134-y665agnh 697 14 , , , cord-023134-y665agnh 697 15 and and CC cord-023134-y665agnh 697 16 84.3 84.3 CD cord-023134-y665agnh 697 17 ± ± CD cord-023134-y665agnh 697 18 31.9 31.9 CD cord-023134-y665agnh 697 19 lmol lmol NNP cord-023134-y665agnh 697 20 / / SYM cord-023134-y665agnh 697 21 L L NNP cord-023134-y665agnh 697 22 , , , cord-023134-y665agnh 697 23 respectively respectively RB cord-023134-y665agnh 697 24 ) ) -RRB- cord-023134-y665agnh 697 25 . . . cord-023134-y665agnh 698 1 Twenty twenty CD cord-023134-y665agnh 698 2 dogs dog NNS cord-023134-y665agnh 698 3 of of IN cord-023134-y665agnh 698 4 each each DT cord-023134-y665agnh 698 5 group group NN cord-023134-y665agnh 698 6 were be VBD cord-023134-y665agnh 698 7 analyzed analyze VBN cord-023134-y665agnh 698 8 for for IN cord-023134-y665agnh 698 9 albumin albumin NN cord-023134-y665agnh 698 10 and and CC cord-023134-y665agnh 698 11 total total JJ cord-023134-y665agnh 698 12 protein protein NN cord-023134-y665agnh 698 13 and and CC cord-023134-y665agnh 698 14 compared compare VBN cord-023134-y665agnh 698 15 to to IN cord-023134-y665agnh 698 16 healthy healthy JJ cord-023134-y665agnh 698 17 dogs dog NNS cord-023134-y665agnh 698 18 that that WDT cord-023134-y665agnh 698 19 were be VBD cord-023134-y665agnh 698 20 not not RB cord-023134-y665agnh 698 21 receiving receive VBG cord-023134-y665agnh 698 22 phenobarbital phenobarbital NN cord-023134-y665agnh 698 23 . . . cord-023134-y665agnh 699 1 No no DT cord-023134-y665agnh 699 2 statistically statistically RB cord-023134-y665agnh 699 3 significant significant JJ cord-023134-y665agnh 699 4 difference difference NN cord-023134-y665agnh 699 5 was be VBD cord-023134-y665agnh 699 6 noticed notice VBN cord-023134-y665agnh 699 7 ( ( -LRB- cord-023134-y665agnh 699 8 p>0.05 p>0.05 NNP cord-023134-y665agnh 699 9 ) ) -RRB- cord-023134-y665agnh 699 10 . . . cord-023134-y665agnh 700 1 The the DT cord-023134-y665agnh 700 2 attempt attempt NN cord-023134-y665agnh 700 3 to to TO cord-023134-y665agnh 700 4 measure measure VB cord-023134-y665agnh 700 5 TTR TTR NNP cord-023134-y665agnh 700 6 concentrations concentration NNS cord-023134-y665agnh 700 7 via via IN cord-023134-y665agnh 700 8 commercially commercially RB cord-023134-y665agnh 700 9 available available JJ cord-023134-y665agnh 700 10 ELISA ELISA NNP cord-023134-y665agnh 701 1 ( ( -LRB- cord-023134-y665agnh 701 2 TSZ TSZ NNP cord-023134-y665agnh 701 3 ELISA ELISA NNP cord-023134-y665agnh 701 4 , , , cord-023134-y665agnh 701 5 Framingham Framingham NNP cord-023134-y665agnh 701 6 , , , cord-023134-y665agnh 701 7 MA MA NNP cord-023134-y665agnh 701 8 , , , cord-023134-y665agnh 701 9 USA USA NNP cord-023134-y665agnh 701 10 ) ) -RRB- cord-023134-y665agnh 701 11 gave give VBD cord-023134-y665agnh 701 12 us -PRON- PRP cord-023134-y665agnh 701 13 inconsistence inconsistence NN cord-023134-y665agnh 701 14 performance performance NN cord-023134-y665agnh 701 15 . . . cord-023134-y665agnh 702 1 In in IN cord-023134-y665agnh 702 2 conclusion conclusion NN cord-023134-y665agnh 702 3 , , , cord-023134-y665agnh 702 4 6 6 CD cord-023134-y665agnh 702 5 % % NN cord-023134-y665agnh 702 6 of of IN cord-023134-y665agnh 702 7 dogs dog NNS cord-023134-y665agnh 702 8 on on IN cord-023134-y665agnh 702 9 phenobarbital phenobarbital JJ cord-023134-y665agnh 702 10 treatment treatment NN cord-023134-y665agnh 702 11 were be VBD cord-023134-y665agnh 702 12 classified classify VBN cord-023134-y665agnh 702 13 as as IN cord-023134-y665agnh 702 14 NTI NTI NNP cord-023134-y665agnh 702 15 . . . cord-023134-y665agnh 703 1 If if IN cord-023134-y665agnh 703 2 group group NN cord-023134-y665agnh 703 3 E e NN cord-023134-y665agnh 703 4 would would MD cord-023134-y665agnh 703 5 be be VB cord-023134-y665agnh 703 6 included include VBN cord-023134-y665agnh 703 7 , , , cord-023134-y665agnh 703 8 this this DT cord-023134-y665agnh 703 9 value value NN cord-023134-y665agnh 703 10 could could MD cord-023134-y665agnh 703 11 be be VB cord-023134-y665agnh 703 12 as as RB cord-023134-y665agnh 703 13 high high JJ cord-023134-y665agnh 703 14 as as IN cord-023134-y665agnh 703 15 13 13 CD cord-023134-y665agnh 703 16 % % NN cord-023134-y665agnh 703 17 . . . cord-023134-y665agnh 704 1 Neither neither CC cord-023134-y665agnh 704 2 phenobarbital phenobarbital NN cord-023134-y665agnh 704 3 , , , cord-023134-y665agnh 704 4 nor nor CC cord-023134-y665agnh 704 5 total total JJ cord-023134-y665agnh 704 6 protein protein NN cord-023134-y665agnh 704 7 or or CC cord-023134-y665agnh 704 8 albumin albumin NN cord-023134-y665agnh 704 9 concentrations concentration NNS cord-023134-y665agnh 704 10 had have VBD cord-023134-y665agnh 704 11 predictive predictive JJ cord-023134-y665agnh 704 12 value value NN cord-023134-y665agnh 704 13 for for IN cord-023134-y665agnh 704 14 thyroid thyroid JJ cord-023134-y665agnh 704 15 hormone hormone NN cord-023134-y665agnh 704 16 concentrations concentration NNS cord-023134-y665agnh 704 17 . . . cord-023134-y665agnh 705 1 This this DT cord-023134-y665agnh 705 2 study study NN cord-023134-y665agnh 705 3 was be VBD cord-023134-y665agnh 705 4 able able JJ cord-023134-y665agnh 705 5 to to TO cord-023134-y665agnh 705 6 define define VB cord-023134-y665agnh 705 7 the the DT cord-023134-y665agnh 705 8 prevalence prevalence NN cord-023134-y665agnh 705 9 of of IN cord-023134-y665agnh 705 10 the the DT cord-023134-y665agnh 705 11 phenomenon phenomenon NN cord-023134-y665agnh 705 12 that that IN cord-023134-y665agnh 705 13 some some DT cord-023134-y665agnh 705 14 dogs dog NNS cord-023134-y665agnh 705 15 on on IN cord-023134-y665agnh 705 16 phenobarbital phenobarbital NN cord-023134-y665agnh 705 17 therapy therapy NN cord-023134-y665agnh 705 18 have have VBP cord-023134-y665agnh 705 19 low low JJ cord-023134-y665agnh 705 20 thyroid thyroid JJ cord-023134-y665agnh 705 21 hormone hormone NN cord-023134-y665agnh 705 22 concentrations concentration NNS cord-023134-y665agnh 705 23 , , , cord-023134-y665agnh 705 24 but but CC cord-023134-y665agnh 705 25 did do VBD cord-023134-y665agnh 705 26 not not RB cord-023134-y665agnh 705 27 give give VB cord-023134-y665agnh 705 28 insight insight NN cord-023134-y665agnh 705 29 into into IN cord-023134-y665agnh 705 30 the the DT cord-023134-y665agnh 705 31 pathogenesis pathogenesis NN cord-023134-y665agnh 705 32 . . . cord-023134-y665agnh 706 1 Ideally ideally RB cord-023134-y665agnh 706 2 , , , cord-023134-y665agnh 706 3 demonstration demonstration NN cord-023134-y665agnh 706 4 of of IN cord-023134-y665agnh 706 5 hypothyroidism hypothyroidism NN cord-023134-y665agnh 706 6 in in IN cord-023134-y665agnh 706 7 dogs dog NNS cord-023134-y665agnh 706 8 receiving receive VBG cord-023134-y665agnh 706 9 phenobarbital phenobarbital NN cord-023134-y665agnh 706 10 should should MD cord-023134-y665agnh 706 11 include include VB cord-023134-y665agnh 706 12 assays assay NNS cord-023134-y665agnh 706 13 of of IN cord-023134-y665agnh 706 14 thyroid thyroid JJ cord-023134-y665agnh 706 15 hormones hormone NNS cord-023134-y665agnh 706 16 and and CC cord-023134-y665agnh 706 17 TSH tsh NN cord-023134-y665agnh 706 18 . . . cord-023134-y665agnh 707 1 Pheochromocytoma Pheochromocytoma NNP cord-023134-y665agnh 707 2 ( ( -LRB- cord-023134-y665agnh 707 3 PHEO PHEO NNP cord-023134-y665agnh 707 4 ) ) -RRB- cord-023134-y665agnh 707 5 is be VBZ cord-023134-y665agnh 707 6 a a DT cord-023134-y665agnh 707 7 rare rare JJ cord-023134-y665agnh 707 8 malignant malignant JJ cord-023134-y665agnh 707 9 catecholamine catecholamine NN cord-023134-y665agnh 707 10 - - HYPH cord-023134-y665agnh 707 11 secreting secrete VBG cord-023134-y665agnh 707 12 tumor tumor NN cord-023134-y665agnh 707 13 of of IN cord-023134-y665agnh 707 14 the the DT cord-023134-y665agnh 707 15 adrenal adrenal JJ cord-023134-y665agnh 707 16 medulla medulla NN cord-023134-y665agnh 707 17 . . . cord-023134-y665agnh 708 1 Catecholamines Catecholamines NNP cord-023134-y665agnh 708 2 and and CC cord-023134-y665agnh 708 3 metanephrines metanephrine NNS cord-023134-y665agnh 708 4 in in IN cord-023134-y665agnh 708 5 plasma plasma NN cord-023134-y665agnh 708 6 and and CC cord-023134-y665agnh 708 7 in in IN cord-023134-y665agnh 708 8 24-h 24-h JJ cord-023134-y665agnh 708 9 urine urine NN cord-023134-y665agnh 708 10 are be VBP cord-023134-y665agnh 708 11 approved approve VBN cord-023134-y665agnh 708 12 biomarkers biomarker NNS cord-023134-y665agnh 708 13 for for IN cord-023134-y665agnh 708 14 the the DT cord-023134-y665agnh 708 15 detection detection NN cord-023134-y665agnh 708 16 of of IN cord-023134-y665agnh 708 17 the the DT cord-023134-y665agnh 708 18 disease disease NN cord-023134-y665agnh 708 19 in in IN cord-023134-y665agnh 708 20 humans human NNS cord-023134-y665agnh 708 21 , , , cord-023134-y665agnh 708 22 however however RB cord-023134-y665agnh 708 23 , , , cord-023134-y665agnh 708 24 the the DT cord-023134-y665agnh 708 25 question question NN cord-023134-y665agnh 708 26 which which WDT cord-023134-y665agnh 708 27 of of IN cord-023134-y665agnh 708 28 the the DT cord-023134-y665agnh 708 29 tests test NNS cord-023134-y665agnh 708 30 is be VBZ cord-023134-y665agnh 708 31 best good JJS cord-023134-y665agnh 708 32 is be VBZ cord-023134-y665agnh 708 33 controversial controversial JJ cord-023134-y665agnh 708 34 . . . cord-023134-y665agnh 709 1 We -PRON- PRP cord-023134-y665agnh 709 2 previously previously RB cord-023134-y665agnh 709 3 demonstrated demonstrate VBD cord-023134-y665agnh 709 4 that that IN cord-023134-y665agnh 709 5 measurement measurement NN cord-023134-y665agnh 709 6 of of IN cord-023134-y665agnh 709 7 urinary urinary JJ cord-023134-y665agnh 709 8 catecholamine catecholamine NN cord-023134-y665agnh 709 9 and and CC cord-023134-y665agnh 709 10 metanephrine metanephrine NN cord-023134-y665agnh 709 11 to to IN cord-023134-y665agnh 709 12 creatinine creatinine NN cord-023134-y665agnh 709 13 ratios ratio NNS cord-023134-y665agnh 709 14 is be VBZ cord-023134-y665agnh 709 15 helpful helpful JJ cord-023134-y665agnh 709 16 for for IN cord-023134-y665agnh 709 17 the the DT cord-023134-y665agnh 709 18 diagnosis diagnosis NN cord-023134-y665agnh 709 19 of of IN cord-023134-y665agnh 709 20 PHEO PHEO NNP cord-023134-y665agnh 709 21 in in IN cord-023134-y665agnh 709 22 dogs dog NNS cord-023134-y665agnh 709 23 and and CC cord-023134-y665agnh 709 24 that that IN cord-023134-y665agnh 709 25 urinary urinary JJ cord-023134-y665agnh 709 26 normetanephrine normetanephrine NN cord-023134-y665agnh 709 27 to to TO cord-023134-y665agnh 709 28 creatinine creatinine NN cord-023134-y665agnh 709 29 ratio ratio NN cord-023134-y665agnh 709 30 may may MD cord-023134-y665agnh 709 31 be be VB cord-023134-y665agnh 709 32 the the DT cord-023134-y665agnh 709 33 best good JJS cord-023134-y665agnh 709 34 test test NN cord-023134-y665agnh 709 35 to to TO cord-023134-y665agnh 709 36 discriminate discriminate VB cord-023134-y665agnh 709 37 between between IN cord-023134-y665agnh 709 38 PHEO PHEO NNP cord-023134-y665agnh 709 39 and and CC cord-023134-y665agnh 709 40 hypercortisolism hypercortisolism NNP cord-023134-y665agnh 709 41 ( ( -LRB- cord-023134-y665agnh 709 42 HC).Knowledge hc).knowledge CD cord-023134-y665agnh 709 43 on on IN cord-023134-y665agnh 709 44 plasma plasma NN cord-023134-y665agnh 709 45 catecholamines catecholamine NNS cord-023134-y665agnh 709 46 and and CC cord-023134-y665agnh 709 47 metanephrines metanephrine NNS cord-023134-y665agnh 709 48 in in IN cord-023134-y665agnh 709 49 dogs dog NNS cord-023134-y665agnh 709 50 is be VBZ cord-023134-y665agnh 709 51 scarce scarce JJ cord-023134-y665agnh 709 52 and and CC cord-023134-y665agnh 709 53 no no DT cord-023134-y665agnh 709 54 comparison comparison NN cord-023134-y665agnh 709 55 between between IN cord-023134-y665agnh 709 56 urinary urinary JJ cord-023134-y665agnh 709 57 and and CC cord-023134-y665agnh 709 58 plasma plasma NN cord-023134-y665agnh 709 59 parameters parameter NNS cord-023134-y665agnh 709 60 has have VBZ cord-023134-y665agnh 709 61 been be VBN cord-023134-y665agnh 709 62 performed perform VBN cord-023134-y665agnh 709 63 . . . cord-023134-y665agnh 710 1 The the DT cord-023134-y665agnh 710 2 objective objective NN cord-023134-y665agnh 710 3 of of IN cord-023134-y665agnh 710 4 the the DT cord-023134-y665agnh 710 5 study study NN cord-023134-y665agnh 710 6 was be VBD cord-023134-y665agnh 710 7 to to TO cord-023134-y665agnh 710 8 measure measure VB cord-023134-y665agnh 710 9 urinary urinary JJ cord-023134-y665agnh 710 10 and and CC cord-023134-y665agnh 710 11 plasma plasma NN cord-023134-y665agnh 710 12 catecholamines catecholamine NNS cord-023134-y665agnh 710 13 and and CC cord-023134-y665agnh 710 14 metanephrines metanephrine NNS cord-023134-y665agnh 710 15 in in IN cord-023134-y665agnh 710 16 dogs dog NNS cord-023134-y665agnh 710 17 with with IN cord-023134-y665agnh 710 18 PHEO PHEO NNP cord-023134-y665agnh 710 19 , , , cord-023134-y665agnh 710 20 HC HC NNP cord-023134-y665agnh 710 21 and and CC cord-023134-y665agnh 710 22 in in IN cord-023134-y665agnh 710 23 healthy healthy JJ cord-023134-y665agnh 710 24 dogs dog NNS cord-023134-y665agnh 710 25 and and CC cord-023134-y665agnh 710 26 to to TO cord-023134-y665agnh 710 27 determine determine VB cord-023134-y665agnh 710 28 the the DT cord-023134-y665agnh 710 29 test test NN cord-023134-y665agnh 710 30 with with IN cord-023134-y665agnh 710 31 the the DT cord-023134-y665agnh 710 32 least least JJS cord-023134-y665agnh 710 33 overlap overlap VB cord-023134-y665agnh 710 34 between between IN cord-023134-y665agnh 710 35 the the DT cord-023134-y665agnh 710 36 groups group NNS cord-023134-y665agnh 710 37 . . . cord-023134-y665agnh 711 1 Six six CD cord-023134-y665agnh 711 2 dogs dog NNS cord-023134-y665agnh 711 3 with with IN cord-023134-y665agnh 711 4 PHEO PHEO NNP cord-023134-y665agnh 711 5 , , , cord-023134-y665agnh 711 6 9 9 CD cord-023134-y665agnh 711 7 dogs dog NNS cord-023134-y665agnh 711 8 with with IN cord-023134-y665agnh 711 9 HC HC NNP cord-023134-y665agnh 711 10 ( ( -LRB- cord-023134-y665agnh 711 11 6 6 CD cord-023134-y665agnh 711 12 with with IN cord-023134-y665agnh 711 13 ATH ATH NNP cord-023134-y665agnh 711 14 , , , cord-023134-y665agnh 711 15 3 3 CD cord-023134-y665agnh 711 16 with with IN cord-023134-y665agnh 711 17 PDH PDH NNP cord-023134-y665agnh 711 18 ) ) -RRB- cord-023134-y665agnh 711 19 and and CC cord-023134-y665agnh 711 20 10 10 CD cord-023134-y665agnh 711 21 healthy healthy JJ cord-023134-y665agnh 711 22 dogs dog NNS cord-023134-y665agnh 711 23 were be VBD cord-023134-y665agnh 711 24 included include VBN cord-023134-y665agnh 711 25 . . . cord-023134-y665agnh 712 1 Urine urine NN cord-023134-y665agnh 712 2 samples sample NNS cord-023134-y665agnh 712 3 were be VBD cord-023134-y665agnh 712 4 collected collect VBN cord-023134-y665agnh 712 5 into into IN cord-023134-y665agnh 712 6 HCL HCL NNP cord-023134-y665agnh 712 7 containing contain VBG cord-023134-y665agnh 712 8 tubes tube NNS cord-023134-y665agnh 712 9 to to TO cord-023134-y665agnh 712 10 ensure ensure VB cord-023134-y665agnh 712 11 a a DT cord-023134-y665agnh 712 12 pH ph NN cord-023134-y665agnh 712 13 < < XX cord-023134-y665agnh 712 14 2 2 CD cord-023134-y665agnh 712 15 , , , cord-023134-y665agnh 712 16 blood blood NN cord-023134-y665agnh 712 17 samples sample NNS cord-023134-y665agnh 712 18 were be VBD cord-023134-y665agnh 712 19 collected collect VBN cord-023134-y665agnh 712 20 on on IN cord-023134-y665agnh 712 21 ice ice NN cord-023134-y665agnh 712 22 , , , cord-023134-y665agnh 712 23 centrifuged centrifuge VBN cord-023134-y665agnh 712 24 at at IN cord-023134-y665agnh 712 25 4 4 CD cord-023134-y665agnh 712 26 ° ° NN cord-023134-y665agnh 712 27 C c NN cord-023134-y665agnh 712 28 and and CC cord-023134-y665agnh 712 29 immediately immediately RB cord-023134-y665agnh 712 30 snap snap VBP cord-023134-y665agnh 712 31 frozen freeze VBN cord-023134-y665agnh 712 32 in in IN cord-023134-y665agnh 712 33 liquid liquid JJ cord-023134-y665agnh 712 34 nitrogen nitrogen NN cord-023134-y665agnh 712 35 . . . cord-023134-y665agnh 713 1 All all DT cord-023134-y665agnh 713 2 samples sample NNS cord-023134-y665agnh 713 3 were be VBD cord-023134-y665agnh 713 4 stored store VBN cord-023134-y665agnh 713 5 at at IN cord-023134-y665agnh 713 6 -80 -80 NNP cord-023134-y665agnh 713 7 ° ° NN cord-023134-y665agnh 713 8 C C NNP cord-023134-y665agnh 713 9 . . . cord-023134-y665agnh 714 1 Urinary urinary JJ cord-023134-y665agnh 714 2 epinephrine epinephrine NN cord-023134-y665agnh 715 1 ( ( -LRB- cord-023134-y665agnh 715 2 U U NNP cord-023134-y665agnh 715 3 - - HYPH cord-023134-y665agnh 715 4 Epi Epi NNP cord-023134-y665agnh 715 5 ) ) -RRB- cord-023134-y665agnh 715 6 , , , cord-023134-y665agnh 715 7 norepinephrine norepinephrine NN cord-023134-y665agnh 715 8 ( ( -LRB- cord-023134-y665agnh 715 9 U U NNP cord-023134-y665agnh 715 10 - - HYPH cord-023134-y665agnh 715 11 Norepi Norepi NNP cord-023134-y665agnh 715 12 ) ) -RRB- cord-023134-y665agnh 715 13 , , . cord-023134-y665agnh 716 1 metanephrine metanephrine NNP cord-023134-y665agnh 716 2 ( ( -LRB- cord-023134-y665agnh 716 3 U U NNP cord-023134-y665agnh 716 4 - - HYPH cord-023134-y665agnh 716 5 Meta Meta NNP cord-023134-y665agnh 716 6 ) ) -RRB- cord-023134-y665agnh 716 7 and and CC cord-023134-y665agnh 716 8 normetanephrine normetanephrine NNP cord-023134-y665agnh 716 9 ( ( -LRB- cord-023134-y665agnh 716 10 U U NNP cord-023134-y665agnh 716 11 - - HYPH cord-023134-y665agnh 716 12 Normeta Normeta NNP cord-023134-y665agnh 716 13 ) ) -RRB- cord-023134-y665agnh 716 14 , , , cord-023134-y665agnh 716 15 and and CC cord-023134-y665agnh 716 16 plasma plasma NN cord-023134-y665agnh 716 17 epinephrine epinephrine NN cord-023134-y665agnh 716 18 ( ( -LRB- cord-023134-y665agnh 716 19 P P NNP cord-023134-y665agnh 716 20 - - HYPH cord-023134-y665agnh 716 21 Epi Epi NNP cord-023134-y665agnh 716 22 ) ) -RRB- cord-023134-y665agnh 716 23 , , , cord-023134-y665agnh 716 24 norepinephrine norepinephrine NN cord-023134-y665agnh 716 25 ( ( -LRB- cord-023134-y665agnh 716 26 P P NNP cord-023134-y665agnh 716 27 - - HYPH cord-023134-y665agnh 716 28 Norepi Norepi NNP cord-023134-y665agnh 716 29 ) ) -RRB- cord-023134-y665agnh 716 30 , , , cord-023134-y665agnh 716 31 free free JJ cord-023134-y665agnh 716 32 and and CC cord-023134-y665agnh 716 33 total total JJ cord-023134-y665agnh 716 34 metanephrine metanephrine NN cord-023134-y665agnh 716 35 ( ( -LRB- cord-023134-y665agnh 716 36 PF PF NNP cord-023134-y665agnh 716 37 - - HYPH cord-023134-y665agnh 716 38 Meta Meta NNP cord-023134-y665agnh 716 39 and and CC cord-023134-y665agnh 716 40 PT PT NNP cord-023134-y665agnh 716 41 - - HYPH cord-023134-y665agnh 716 42 Meta Meta NNP cord-023134-y665agnh 716 43 ) ) -RRB- cord-023134-y665agnh 716 44 and and CC cord-023134-y665agnh 716 45 free free JJ cord-023134-y665agnh 716 46 and and CC cord-023134-y665agnh 716 47 total total JJ cord-023134-y665agnh 716 48 normetanephrine normetanephrine NN cord-023134-y665agnh 716 49 ( ( -LRB- cord-023134-y665agnh 716 50 PF PF NNP cord-023134-y665agnh 716 51 - - HYPH cord-023134-y665agnh 716 52 Normeta Normeta NNP cord-023134-y665agnh 716 53 and and CC cord-023134-y665agnh 716 54 PT PT NNP cord-023134-y665agnh 716 55 - - HYPH cord-023134-y665agnh 716 56 Meta Meta NNP cord-023134-y665agnh 716 57 ) ) -RRB- cord-023134-y665agnh 716 58 were be VBD cord-023134-y665agnh 716 59 analysed analyse VBN cord-023134-y665agnh 716 60 by by IN cord-023134-y665agnh 716 61 HPLC HPLC NNP cord-023134-y665agnh 716 62 . . . cord-023134-y665agnh 717 1 Urinary urinary JJ cord-023134-y665agnh 717 2 catecholamines catecholamine NNS cord-023134-y665agnh 717 3 and and CC cord-023134-y665agnh 717 4 metanephrines metanephrine NNS cord-023134-y665agnh 717 5 were be VBD cord-023134-y665agnh 717 6 expressed express VBN cord-023134-y665agnh 717 7 as as IN cord-023134-y665agnh 717 8 ratios ratio NNS cord-023134-y665agnh 717 9 to to TO cord-023134-y665agnh 717 10 urine urine VB cord-023134-y665agnh 717 11 creatinine creatinine NN cord-023134-y665agnh 717 12 concentrations concentration NNS cord-023134-y665agnh 717 13 . . . cord-023134-y665agnh 718 1 Data datum NNS cord-023134-y665agnh 718 2 were be VBD cord-023134-y665agnh 718 3 analysed analyse VBN cord-023134-y665agnh 718 4 by by IN cord-023134-y665agnh 718 5 non non JJ cord-023134-y665agnh 718 6 - - JJ cord-023134-y665agnh 718 7 parametric parametric JJ cord-023134-y665agnh 718 8 tests test NNS cord-023134-y665agnh 718 9 ( ( -LRB- cord-023134-y665agnh 718 10 P p NN cord-023134-y665agnh 718 11 < < XX cord-023134-y665agnh 718 12 0,05).Similar 0,05).similar CD cord-023134-y665agnh 718 13 to to IN cord-023134-y665agnh 718 14 our -PRON- PRP$ cord-023134-y665agnh 718 15 previous previous JJ cord-023134-y665agnh 718 16 findings finding NNS cord-023134-y665agnh 719 1 U U NNP cord-023134-y665agnh 719 2 - - HYPH cord-023134-y665agnh 719 3 Epi Epi NNP cord-023134-y665agnh 719 4 , , , cord-023134-y665agnh 719 5 U U NNP cord-023134-y665agnh 719 6 - - HYPH cord-023134-y665agnh 719 7 Norepi Norepi NNP cord-023134-y665agnh 719 8 , , , cord-023134-y665agnh 719 9 U U NNP cord-023134-y665agnh 719 10 - - HYPH cord-023134-y665agnh 719 11 Meta Meta NNP cord-023134-y665agnh 719 12 and and CC cord-023134-y665agnh 719 13 U U NNP cord-023134-y665agnh 719 14 - - HYPH cord-023134-y665agnh 719 15 Normeta Normeta NNP cord-023134-y665agnh 719 16 were be VBD cord-023134-y665agnh 719 17 significantly significantly RB cord-023134-y665agnh 719 18 higher high JJR cord-023134-y665agnh 719 19 in in IN cord-023134-y665agnh 719 20 dogs dog NNS cord-023134-y665agnh 719 21 with with IN cord-023134-y665agnh 719 22 PHEO PHEO NNP cord-023134-y665agnh 719 23 and and CC cord-023134-y665agnh 719 24 U U NNP cord-023134-y665agnh 719 25 - - HYPH cord-023134-y665agnh 719 26 Norepi Norepi NNPS cord-023134-y665agnh 719 27 and and CC cord-023134-y665agnh 719 28 U U NNP cord-023134-y665agnh 719 29 - - HYPH cord-023134-y665agnh 719 30 Normeta Normeta NNP cord-023134-y665agnh 719 31 were be VBD cord-023134-y665agnh 719 32 significantly significantly RB cord-023134-y665agnh 719 33 higher high JJR cord-023134-y665agnh 719 34 in in IN cord-023134-y665agnh 719 35 dogs dog NNS cord-023134-y665agnh 719 36 with with IN cord-023134-y665agnh 719 37 HC HC NNP cord-023134-y665agnh 719 38 compared compare VBN cord-023134-y665agnh 719 39 to to IN cord-023134-y665agnh 719 40 healthy healthy JJ cord-023134-y665agnh 719 41 dogs dog NNS cord-023134-y665agnh 719 42 . . . cord-023134-y665agnh 720 1 Comparison comparison NN cord-023134-y665agnh 720 2 between between IN cord-023134-y665agnh 720 3 dogs dog NNS cord-023134-y665agnh 720 4 with with IN cord-023134-y665agnh 720 5 HC HC NNP cord-023134-y665agnh 720 6 and and CC cord-023134-y665agnh 720 7 dogs dog NNS cord-023134-y665agnh 720 8 with with IN cord-023134-y665agnh 720 9 PHEO PHEO NNP cord-023134-y665agnh 720 10 revealed reveal VBD cord-023134-y665agnh 720 11 significantly significantly RB cord-023134-y665agnh 720 12 higher high JJR cord-023134-y665agnh 720 13 U U NNP cord-023134-y665agnh 720 14 - - HYPH cord-023134-y665agnh 720 15 Meta Meta NNP cord-023134-y665agnh 720 16 and and CC cord-023134-y665agnh 720 17 U U NNP cord-023134-y665agnh 720 18 - - HYPH cord-023134-y665agnh 720 19 Normeta Normeta NNP cord-023134-y665agnh 720 20 in in IN cord-023134-y665agnh 720 21 the the DT cord-023134-y665agnh 720 22 latter latter JJ cord-023134-y665agnh 720 23 group group NN cord-023134-y665agnh 720 24 . . . cord-023134-y665agnh 721 1 U U NNP cord-023134-y665agnh 721 2 - - HYPH cord-023134-y665agnh 721 3 Normeta Normeta NNP cord-023134-y665agnh 721 4 was be VBD cord-023134-y665agnh 721 5 the the DT cord-023134-y665agnh 721 6 only only JJ cord-023134-y665agnh 721 7 parameter parameter NN cord-023134-y665agnh 721 8 with with IN cord-023134-y665agnh 721 9 no no DT cord-023134-y665agnh 721 10 overlap overlap NN cord-023134-y665agnh 721 11 . . . cord-023134-y665agnh 722 1 In in IN cord-023134-y665agnh 722 2 dogs dog NNS cord-023134-y665agnh 722 3 with with IN cord-023134-y665agnh 722 4 PHEO PHEO NNP cord-023134-y665agnh 722 5 P P NNP cord-023134-y665agnh 722 6 - - HYPH cord-023134-y665agnh 722 7 Norepi Norepi NNP cord-023134-y665agnh 722 8 , , , cord-023134-y665agnh 722 9 PF PF NNP cord-023134-y665agnh 722 10 - - HYPH cord-023134-y665agnh 722 11 Meta Meta NNP cord-023134-y665agnh 722 12 , , , cord-023134-y665agnh 722 13 PT PT NNP cord-023134-y665agnh 722 14 - - HYPH cord-023134-y665agnh 722 15 Meta Meta NNP cord-023134-y665agnh 722 16 , , , cord-023134-y665agnh 723 1 PF PF NNP cord-023134-y665agnh 723 2 - - HYPH cord-023134-y665agnh 723 3 Normeta Normeta NNP cord-023134-y665agnh 723 4 , , , cord-023134-y665agnh 723 5 PT PT NNP cord-023134-y665agnh 723 6 - - : cord-023134-y665agnh 723 7 Normeta Normeta NNP cord-023134-y665agnh 723 8 were be VBD cord-023134-y665agnh 723 9 significantly significantly RB cord-023134-y665agnh 723 10 higher high JJR cord-023134-y665agnh 723 11 and and CC cord-023134-y665agnh 723 12 in in IN cord-023134-y665agnh 723 13 dogs dog NNS cord-023134-y665agnh 723 14 with with IN cord-023134-y665agnh 723 15 HC HC NNP cord-023134-y665agnh 723 16 P P NNP cord-023134-y665agnh 723 17 - - HYPH cord-023134-y665agnh 723 18 Norepi Norepi NNP cord-023134-y665agnh 723 19 , , , cord-023134-y665agnh 723 20 PF PF NNP cord-023134-y665agnh 723 21 - - HYPH cord-023134-y665agnh 723 22 Normeta Normeta NNP cord-023134-y665agnh 723 23 and and CC cord-023134-y665agnh 723 24 PT PT NNP cord-023134-y665agnh 723 25 - - : cord-023134-y665agnh 723 26 Normeta Normeta NNP cord-023134-y665agnh 723 27 were be VBD cord-023134-y665agnh 723 28 significantly significantly RB cord-023134-y665agnh 723 29 higher high JJR cord-023134-y665agnh 723 30 than than IN cord-023134-y665agnh 723 31 in in IN cord-023134-y665agnh 723 32 healthy healthy JJ cord-023134-y665agnh 723 33 dogs dog NNS cord-023134-y665agnh 723 34 . . . cord-023134-y665agnh 724 1 Comparison comparison NN cord-023134-y665agnh 724 2 between between IN cord-023134-y665agnh 724 3 dogs dog NNS cord-023134-y665agnh 724 4 with with IN cord-023134-y665agnh 724 5 HC HC NNP cord-023134-y665agnh 724 6 and and CC cord-023134-y665agnh 724 7 dogs dog NNS cord-023134-y665agnh 724 8 with with IN cord-023134-y665agnh 724 9 PHEO PHEO NNP cord-023134-y665agnh 724 10 showed show VBD cord-023134-y665agnh 724 11 significant significant JJ cord-023134-y665agnh 724 12 higher high JJR cord-023134-y665agnh 724 13 PF PF NNP cord-023134-y665agnh 724 14 - - HYPH cord-023134-y665agnh 724 15 Meta Meta NNP cord-023134-y665agnh 724 16 , , , cord-023134-y665agnh 724 17 PT PT NNP cord-023134-y665agnh 724 18 - - HYPH cord-023134-y665agnh 724 19 Meta Meta NNP cord-023134-y665agnh 724 20 , , , cord-023134-y665agnh 724 21 PF PF NNP cord-023134-y665agnh 724 22 - - HYPH cord-023134-y665agnh 724 23 Normeta Normeta NNP cord-023134-y665agnh 724 24 , , , cord-023134-y665agnh 724 25 PT PT NNP cord-023134-y665agnh 724 26 - - HYPH cord-023134-y665agnh 724 27 Normeta Normeta NNP cord-023134-y665agnh 724 28 in in IN cord-023134-y665agnh 724 29 the the DT cord-023134-y665agnh 724 30 PHEO PHEO NNP cord-023134-y665agnh 724 31 group group NN cord-023134-y665agnh 724 32 . . . cord-023134-y665agnh 725 1 Overlap Overlap NNP cord-023134-y665agnh 725 2 was be VBD cord-023134-y665agnh 725 3 present present JJ cord-023134-y665agnh 725 4 with with IN cord-023134-y665agnh 725 5 all all DT cord-023134-y665agnh 725 6 4 4 CD cord-023134-y665agnh 725 7 parameters parameter NNS cord-023134-y665agnh 725 8 , , , cord-023134-y665agnh 725 9 but but CC cord-023134-y665agnh 725 10 was be VBD cord-023134-y665agnh 725 11 least least JJS cord-023134-y665agnh 725 12 with with IN cord-023134-y665agnh 725 13 PF PF NNP cord-023134-y665agnh 725 14 - - HYPH cord-023134-y665agnh 725 15 Normeta Normeta NNP cord-023134-y665agnh 725 16 and and CC cord-023134-y665agnh 725 17 PT PT NNP cord-023134-y665agnh 725 18 - - HYPH cord-023134-y665agnh 725 19 Normeta Normeta NNP cord-023134-y665agnh 725 20 . . . cord-023134-y665agnh 726 1 According accord VBG cord-023134-y665agnh 726 2 to to IN cord-023134-y665agnh 726 3 our -PRON- PRP$ cord-023134-y665agnh 726 4 preliminary preliminary JJ cord-023134-y665agnh 726 5 results result NNS cord-023134-y665agnh 726 6 U U NNP cord-023134-y665agnh 726 7 - - HYPH cord-023134-y665agnh 726 8 Normeta Normeta NNP cord-023134-y665agnh 726 9 , , , cord-023134-y665agnh 726 10 PF PF NNP cord-023134-y665agnh 726 11 - - HYPH cord-023134-y665agnh 726 12 Normeta Normeta NNP cord-023134-y665agnh 726 13 and and CC cord-023134-y665agnh 726 14 PT PT NNP cord-023134-y665agnh 727 1 -Normeta -normeta NN cord-023134-y665agnh 727 2 are be VBP cord-023134-y665agnh 727 3 valuable valuable JJ cord-023134-y665agnh 727 4 parameters parameter NNS cord-023134-y665agnh 727 5 for for IN cord-023134-y665agnh 727 6 the the DT cord-023134-y665agnh 727 7 diagnosis diagnosis NN cord-023134-y665agnh 727 8 of of IN cord-023134-y665agnh 727 9 PHEO PHEO NNP cord-023134-y665agnh 727 10 , , , cord-023134-y665agnh 727 11 so so RB cord-023134-y665agnh 727 12 far far RB cord-023134-y665agnh 727 13 U U NNP cord-023134-y665agnh 727 14 - - HYPH cord-023134-y665agnh 727 15 Normeta Normeta NNP cord-023134-y665agnh 727 16 has have VBZ cord-023134-y665agnh 727 17 performed perform VBN cord-023134-y665agnh 727 18 better well RBR cord-023134-y665agnh 727 19 than than IN cord-023134-y665agnh 727 20 the the DT cord-023134-y665agnh 727 21 plasma plasma NN cord-023134-y665agnh 727 22 parameters parameter NNS cord-023134-y665agnh 727 23 . . . cord-023134-y665agnh 728 1 Chronic chronic JJ cord-023134-y665agnh 728 2 kidney kidney NN cord-023134-y665agnh 728 3 disease disease NN cord-023134-y665agnh 728 4 ( ( -LRB- cord-023134-y665agnh 728 5 CKD CKD NNP cord-023134-y665agnh 728 6 ) ) -RRB- cord-023134-y665agnh 728 7 is be VBZ cord-023134-y665agnh 728 8 common common JJ cord-023134-y665agnh 728 9 in in IN cord-023134-y665agnh 728 10 geriatric geriatric JJ cord-023134-y665agnh 728 11 cats cat NNS cord-023134-y665agnh 728 12 and and CC cord-023134-y665agnh 728 13 hypoxia hypoxia NN cord-023134-y665agnh 728 14 might may MD cord-023134-y665agnh 728 15 contribute contribute VB cord-023134-y665agnh 728 16 to to IN cord-023134-y665agnh 728 17 CKD CKD NNP cord-023134-y665agnh 728 18 progression progression NN cord-023134-y665agnh 728 19 . . . cord-023134-y665agnh 729 1 Vascular vascular JJ cord-023134-y665agnh 729 2 endothelial endothelial JJ cord-023134-y665agnh 729 3 growth growth NN cord-023134-y665agnh 729 4 factor factor NN cord-023134-y665agnh 729 5 ( ( -LRB- cord-023134-y665agnh 729 6 VEGF VEGF NNP cord-023134-y665agnh 729 7 ) ) -RRB- cord-023134-y665agnh 729 8 is be VBZ cord-023134-y665agnh 729 9 a a DT cord-023134-y665agnh 729 10 marker marker NN cord-023134-y665agnh 729 11 of of IN cord-023134-y665agnh 729 12 hypoxia hypoxia NN cord-023134-y665agnh 729 13 . . . cord-023134-y665agnh 730 1 The the DT cord-023134-y665agnh 730 2 aim aim NN cord-023134-y665agnh 730 3 of of IN cord-023134-y665agnh 730 4 this this DT cord-023134-y665agnh 730 5 study study NN cord-023134-y665agnh 730 6 was be VBD cord-023134-y665agnh 730 7 to to TO cord-023134-y665agnh 730 8 evaluate evaluate VB cord-023134-y665agnh 730 9 urinary urinary JJ cord-023134-y665agnh 730 10 VEGF vegf NN cord-023134-y665agnh 730 11 as as IN cord-023134-y665agnh 730 12 a a DT cord-023134-y665agnh 730 13 prognostic prognostic JJ cord-023134-y665agnh 730 14 marker marker NN cord-023134-y665agnh 730 15 in in IN cord-023134-y665agnh 730 16 cats cat NNS cord-023134-y665agnh 730 17 with with IN cord-023134-y665agnh 730 18 CKD CKD NNP cord-023134-y665agnh 730 19 compared compare VBN cord-023134-y665agnh 730 20 with with IN cord-023134-y665agnh 730 21 the the DT cord-023134-y665agnh 730 22 established establish VBN cord-023134-y665agnh 730 23 progression progression NN cord-023134-y665agnh 730 24 factors factor NNS cord-023134-y665agnh 730 25 , , , cord-023134-y665agnh 730 26 proteinuria proteinuria NN cord-023134-y665agnh 730 27 and and CC cord-023134-y665agnh 730 28 hyperphosphataemia hyperphosphataemia NN cord-023134-y665agnh 730 29 . . . cord-023134-y665agnh 731 1 Cats cat NNS cord-023134-y665agnh 731 2 were be VBD cord-023134-y665agnh 731 3 recruited recruit VBN cord-023134-y665agnh 731 4 through through IN cord-023134-y665agnh 731 5 geriatric geriatric JJ cord-023134-y665agnh 731 6 clinics clinic NNS cord-023134-y665agnh 731 7 held hold VBN cord-023134-y665agnh 731 8 at at IN cord-023134-y665agnh 731 9 two two CD cord-023134-y665agnh 731 10 first first JJ cord-023134-y665agnh 731 11 opinion opinion NN cord-023134-y665agnh 731 12 London London NNP cord-023134-y665agnh 731 13 practices practice NNS cord-023134-y665agnh 731 14 between between IN cord-023134-y665agnh 731 15 1999 1999 CD cord-023134-y665agnh 731 16 and and CC cord-023134-y665agnh 731 17 2010 2010 CD cord-023134-y665agnh 731 18 . . . cord-023134-y665agnh 732 1 Diagnosis diagnosis NN cord-023134-y665agnh 732 2 of of IN cord-023134-y665agnh 732 3 CKD CKD NNP cord-023134-y665agnh 732 4 was be VBD cord-023134-y665agnh 732 5 based base VBN cord-023134-y665agnh 732 6 on on IN cord-023134-y665agnh 732 7 concurrent concurrent JJ cord-023134-y665agnh 732 8 findings finding NNS cord-023134-y665agnh 732 9 of of IN cord-023134-y665agnh 732 10 plasma plasma NN cord-023134-y665agnh 732 11 creatinine creatinine NN cord-023134-y665agnh 732 12 > > XX cord-023134-y665agnh 732 13 2mg 2mg NNP cord-023134-y665agnh 732 14 / / SYM cord-023134-y665agnh 732 15 dl dl NN cord-023134-y665agnh 732 16 and and CC cord-023134-y665agnh 732 17 USG USG NNP cord-023134-y665agnh 732 18 < < XX cord-023134-y665agnh 732 19 1.035 1.035 CD cord-023134-y665agnh 732 20 , , , cord-023134-y665agnh 732 21 with with IN cord-023134-y665agnh 732 22 persistence persistence NN cord-023134-y665agnh 732 23 of of IN cord-023134-y665agnh 732 24 azotaemia azotaemia NN cord-023134-y665agnh 732 25 for for IN cord-023134-y665agnh 732 26 at at RB cord-023134-y665agnh 732 27 least least JJS cord-023134-y665agnh 732 28 2 2 CD cord-023134-y665agnh 732 29 weeks week NNS cord-023134-y665agnh 732 30 . . . cord-023134-y665agnh 733 1 VEGF VEGF NNP cord-023134-y665agnh 733 2 was be VBD cord-023134-y665agnh 733 3 measured measure VBN cord-023134-y665agnh 733 4 in in IN cord-023134-y665agnh 733 5 urine urine NN cord-023134-y665agnh 733 6 samples sample NNS cord-023134-y665agnh 733 7 taken take VBN cord-023134-y665agnh 733 8 from from IN cord-023134-y665agnh 733 9 cats cat NNS cord-023134-y665agnh 733 10 at at IN cord-023134-y665agnh 733 11 diagnosis diagnosis NN cord-023134-y665agnh 733 12 of of IN cord-023134-y665agnh 733 13 CKD CKD NNP cord-023134-y665agnh 733 14 and and CC cord-023134-y665agnh 733 15 indexed index VBN cord-023134-y665agnh 733 16 to to IN cord-023134-y665agnh 733 17 creatinine creatinine VB cord-023134-y665agnh 733 18 giving give VBG cord-023134-y665agnh 733 19 VEGF vegf NN cord-023134-y665agnh 733 20 : : : cord-023134-y665agnh 733 21 creatinine creatinine NN cord-023134-y665agnh 733 22 ratios ratio NNS cord-023134-y665agnh 733 23 ( ( -LRB- cord-023134-y665agnh 733 24 UVC UVC NNP cord-023134-y665agnh 733 25 ) ) -RRB- cord-023134-y665agnh 733 26 . . . cord-023134-y665agnh 734 1 Survival survival NN cord-023134-y665agnh 734 2 was be VBD cord-023134-y665agnh 734 3 compared compare VBN cord-023134-y665agnh 734 4 among among IN cord-023134-y665agnh 734 5 low low JJ cord-023134-y665agnh 734 6 ( ( -LRB- cord-023134-y665agnh 734 7 < < NNP cord-023134-y665agnh 734 8 0.3lg 0.3lg NNP cord-023134-y665agnh 734 9 / / SYM cord-023134-y665agnh 734 10 g g NN cord-023134-y665agnh 734 11 ) ) -RRB- cord-023134-y665agnh 734 12 , , , cord-023134-y665agnh 734 13 medium medium NN cord-023134-y665agnh 734 14 ( ( -LRB- cord-023134-y665agnh 734 15 0.3 0.3 CD cord-023134-y665agnh 734 16 - - HYPH cord-023134-y665agnh 734 17 0.6lg 0.6lg CD cord-023134-y665agnh 734 18 / / SYM cord-023134-y665agnh 734 19 g g NN cord-023134-y665agnh 734 20 ) ) -RRB- cord-023134-y665agnh 734 21 and and CC cord-023134-y665agnh 734 22 high high JJ cord-023134-y665agnh 734 23 ( ( -LRB- cord-023134-y665agnh 734 24 > > NFP cord-023134-y665agnh 734 25 0.6lg 0.6lg CD cord-023134-y665agnh 734 26 / / SYM cord-023134-y665agnh 734 27 g g NN cord-023134-y665agnh 734 28 ) ) -RRB- cord-023134-y665agnh 734 29 categories category NNS cord-023134-y665agnh 734 30 of of IN cord-023134-y665agnh 734 31 UVC UVC NNP cord-023134-y665agnh 734 32 using use VBG cord-023134-y665agnh 734 33 the the DT cord-023134-y665agnh 734 34 log log NN cord-023134-y665agnh 734 35 - - HYPH cord-023134-y665agnh 734 36 rank rank NN cord-023134-y665agnh 734 37 test test NN cord-023134-y665agnh 734 38 . . . cord-023134-y665agnh 735 1 Multivariable multivariable JJ cord-023134-y665agnh 735 2 binary binary JJ cord-023134-y665agnh 735 3 logistic logistic JJ cord-023134-y665agnh 735 4 regression regression NN cord-023134-y665agnh 735 5 was be VBD cord-023134-y665agnh 735 6 used use VBN cord-023134-y665agnh 735 7 to to TO cord-023134-y665agnh 735 8 assess assess VB cord-023134-y665agnh 735 9 whether whether IN cord-023134-y665agnh 735 10 UVC UVC NNP cord-023134-y665agnh 735 11 was be VBD cord-023134-y665agnh 735 12 associated associate VBN cord-023134-y665agnh 735 13 with with IN cord-023134-y665agnh 735 14 an an DT cord-023134-y665agnh 735 15 increase increase NN cord-023134-y665agnh 735 16 in in IN cord-023134-y665agnh 735 17 plasma plasma NN cord-023134-y665agnh 735 18 creatinine creatinine NN cord-023134-y665agnh 735 19 concentration concentration NN cord-023134-y665agnh 735 20 of of IN cord-023134-y665agnh 735 21 at at RB cord-023134-y665agnh 735 22 least least RBS cord-023134-y665agnh 735 23 25 25 CD cord-023134-y665agnh 735 24 % % NN cord-023134-y665agnh 735 25 within within IN cord-023134-y665agnh 735 26 1 1 CD cord-023134-y665agnh 735 27 year year NN cord-023134-y665agnh 735 28 of of IN cord-023134-y665agnh 735 29 diagnosis diagnosis NN cord-023134-y665agnh 735 30 . . . cord-023134-y665agnh 736 1 Cats cat NNS cord-023134-y665agnh 736 2 which which WDT cord-023134-y665agnh 736 3 did do VBD cord-023134-y665agnh 736 4 not not RB cord-023134-y665agnh 736 5 demonstrate demonstrate VB cord-023134-y665agnh 736 6 progression progression NN cord-023134-y665agnh 736 7 but but CC cord-023134-y665agnh 736 8 were be VBD cord-023134-y665agnh 736 9 followed follow VBN cord-023134-y665agnh 736 10 for for IN cord-023134-y665agnh 736 11 < < NNP cord-023134-y665agnh 736 12 1year 1year CD cord-023134-y665agnh 736 13 were be VBD cord-023134-y665agnh 736 14 excluded exclude VBN cord-023134-y665agnh 736 15 from from IN cord-023134-y665agnh 736 16 the the DT cord-023134-y665agnh 736 17 study study NN cord-023134-y665agnh 736 18 . . . cord-023134-y665agnh 737 1 Cases case NNS cord-023134-y665agnh 737 2 which which WDT cord-023134-y665agnh 737 3 developed develop VBD cord-023134-y665agnh 737 4 hyperthyroidism hyperthyroidism NN cord-023134-y665agnh 737 5 , , , cord-023134-y665agnh 737 6 received receive VBD cord-023134-y665agnh 737 7 ACE ace NN cord-023134-y665agnh 737 8 inhibitors inhibitor NNS cord-023134-y665agnh 737 9 , , , cord-023134-y665agnh 737 10 had have VBD cord-023134-y665agnh 737 11 gross gross JJ cord-023134-y665agnh 737 12 haematuria haematuria NNS cord-023134-y665agnh 737 13 , , , cord-023134-y665agnh 737 14 urinary urinary JJ cord-023134-y665agnh 737 15 tract tract JJ cord-023134-y665agnh 737 16 infections infection NNS cord-023134-y665agnh 737 17 , , , cord-023134-y665agnh 737 18 nephrotic nephrotic JJ cord-023134-y665agnh 737 19 syndrome syndrome NN cord-023134-y665agnh 737 20 or or CC cord-023134-y665agnh 737 21 evidence evidence NN cord-023134-y665agnh 737 22 of of IN cord-023134-y665agnh 737 23 bladder bladder NN cord-023134-y665agnh 737 24 neoplasia neoplasia NNS cord-023134-y665agnh 737 25 were be VBD cord-023134-y665agnh 737 26 also also RB cord-023134-y665agnh 737 27 excluded exclude VBN cord-023134-y665agnh 737 28 . . . cord-023134-y665agnh 738 1 Survival survival NN cord-023134-y665agnh 738 2 data datum NNS cord-023134-y665agnh 738 3 are be VBP cord-023134-y665agnh 738 4 presented present VBN cord-023134-y665agnh 738 5 as as IN cord-023134-y665agnh 738 6 median median JJ cord-023134-y665agnh 738 7 [ [ -LRB- cord-023134-y665agnh 738 8 95 95 CD cord-023134-y665agnh 738 9 % % NN cord-023134-y665agnh 738 10 confidence confidence NN cord-023134-y665agnh 738 11 interval interval NN cord-023134-y665agnh 738 12 ] ] -RRB- cord-023134-y665agnh 738 13 and and CC cord-023134-y665agnh 738 14 other other JJ cord-023134-y665agnh 738 15 descriptive descriptive JJ cord-023134-y665agnh 738 16 data datum NNS cord-023134-y665agnh 738 17 are be VBP cord-023134-y665agnh 738 18 presented present VBN cord-023134-y665agnh 738 19 as as IN cord-023134-y665agnh 738 20 median median NN cord-023134-y665agnh 738 21 ( ( -LRB- cord-023134-y665agnh 738 22 25 25 CD cord-023134-y665agnh 738 23 th th XX cord-023134-y665agnh 738 24 , , , cord-023134-y665agnh 738 25 75 75 CD cord-023134-y665agnh 738 26 th th XX cord-023134-y665agnh 738 27 percentile percentile NN cord-023134-y665agnh 738 28 ) ) -RRB- cord-023134-y665agnh 738 29 . . . cord-023134-y665agnh 739 1 Significance significance NN cord-023134-y665agnh 739 2 was be VBD cord-023134-y665agnh 739 3 set set VBN cord-023134-y665agnh 739 4 at at IN cord-023134-y665agnh 739 5 p<0.05 p<0.05 CD cord-023134-y665agnh 739 6 . . . cord-023134-y665agnh 740 1 Cats cat NNS cord-023134-y665agnh 740 2 with with IN cord-023134-y665agnh 740 3 low low JJ cord-023134-y665agnh 740 4 UVC uvc NN cord-023134-y665agnh 740 5 ( ( -LRB- cord-023134-y665agnh 740 6 n=49 n=49 NNP cord-023134-y665agnh 740 7 ) ) -RRB- cord-023134-y665agnh 740 8 had have VBD cord-023134-y665agnh 740 9 survival survival NN cord-023134-y665agnh 740 10 of of IN cord-023134-y665agnh 740 11 840 840 CD cord-023134-y665agnh 740 12 [ [ -LRB- cord-023134-y665agnh 740 13 574 574 CD cord-023134-y665agnh 740 14 , , , cord-023134-y665agnh 740 15 1106 1106 CD cord-023134-y665agnh 740 16 ] ] -RRB- cord-023134-y665agnh 740 17 days day NNS cord-023134-y665agnh 740 18 , , , cord-023134-y665agnh 740 19 while while IN cord-023134-y665agnh 740 20 those those DT cord-023134-y665agnh 740 21 with with IN cord-023134-y665agnh 740 22 medium medium NN cord-023134-y665agnh 740 23 ( ( -LRB- cord-023134-y665agnh 740 24 n=30 n=30 NNP cord-023134-y665agnh 740 25 ) ) -RRB- cord-023134-y665agnh 740 26 and and CC cord-023134-y665agnh 740 27 high high JJ cord-023134-y665agnh 740 28 UVC UVC NNP cord-023134-y665agnh 740 29 ( ( -LRB- cord-023134-y665agnh 740 30 n=10 n=10 NNP cord-023134-y665agnh 740 31 ) ) -RRB- cord-023134-y665agnh 740 32 had have VBD cord-023134-y665agnh 740 33 survival survival NN cord-023134-y665agnh 740 34 of of IN cord-023134-y665agnh 740 35 863 863 CD cord-023134-y665agnh 740 36 [ [ -LRB- cord-023134-y665agnh 740 37 385 385 CD cord-023134-y665agnh 740 38 , , , cord-023134-y665agnh 740 39 1341 1341 CD cord-023134-y665agnh 740 40 ] ] -RRB- cord-023134-y665agnh 740 41 days day NNS cord-023134-y665agnh 740 42 and and CC cord-023134-y665agnh 740 43 260 260 CD cord-023134-y665agnh 740 44 [ [ -LRB- cord-023134-y665agnh 740 45 0 0 CD cord-023134-y665agnh 740 46 , , , cord-023134-y665agnh 740 47 554 554 CD cord-023134-y665agnh 740 48 ] ] -RRB- cord-023134-y665agnh 740 49 days day NNS cord-023134-y665agnh 740 50 respectively respectively RB cord-023134-y665agnh 740 51 . . . cord-023134-y665agnh 741 1 There there EX cord-023134-y665agnh 741 2 was be VBD cord-023134-y665agnh 741 3 no no DT cord-023134-y665agnh 741 4 difference difference NN cord-023134-y665agnh 741 5 in in IN cord-023134-y665agnh 741 6 survival survival NN cord-023134-y665agnh 741 7 time time NN cord-023134-y665agnh 741 8 between between IN cord-023134-y665agnh 741 9 cats cat NNS cord-023134-y665agnh 741 10 with with IN cord-023134-y665agnh 741 11 low low JJ cord-023134-y665agnh 741 12 and and CC cord-023134-y665agnh 741 13 medium medium JJ cord-023134-y665agnh 741 14 values value NNS cord-023134-y665agnh 741 15 of of IN cord-023134-y665agnh 741 16 UVC UVC NNP cord-023134-y665agnh 741 17 ( ( -LRB- cord-023134-y665agnh 741 18 p=0.414 p=0.414 NNP cord-023134-y665agnh 741 19 ) ) -RRB- cord-023134-y665agnh 741 20 , , , cord-023134-y665agnh 741 21 but but CC cord-023134-y665agnh 741 22 cats cat NNS cord-023134-y665agnh 741 23 with with IN cord-023134-y665agnh 741 24 both both CC cord-023134-y665agnh 741 25 low low JJ cord-023134-y665agnh 741 26 ( ( -LRB- cord-023134-y665agnh 741 27 p<0.001 p<0.001 JJ cord-023134-y665agnh 741 28 ) ) -RRB- cord-023134-y665agnh 741 29 and and CC cord-023134-y665agnh 741 30 medium medium NN cord-023134-y665agnh 741 31 ( ( -LRB- cord-023134-y665agnh 741 32 p=0.002 p=0.002 NNP cord-023134-y665agnh 741 33 ) ) -RRB- cord-023134-y665agnh 742 1 UVC UVC NNP cord-023134-y665agnh 742 2 had have VBD cord-023134-y665agnh 742 3 significantly significantly RB cord-023134-y665agnh 742 4 longer long JJR cord-023134-y665agnh 742 5 survival survival NN cord-023134-y665agnh 742 6 than than IN cord-023134-y665agnh 742 7 cats cat NNS cord-023134-y665agnh 742 8 with with IN cord-023134-y665agnh 742 9 high high JJ cord-023134-y665agnh 742 10 UVC uvc NN cord-023134-y665agnh 742 11 . . . cord-023134-y665agnh 743 1 Plasma plasma NN cord-023134-y665agnh 743 2 creatinine creatinine NN cord-023134-y665agnh 743 3 concentration concentration NN cord-023134-y665agnh 743 4 increased increase VBD cord-023134-y665agnh 743 5 by by IN cord-023134-y665agnh 743 6 52(33 52(33 CD cord-023134-y665agnh 743 7 , , , cord-023134-y665agnh 743 8 109)% 109)% CD cord-023134-y665agnh 743 9 in in IN cord-023134-y665agnh 743 10 cats cat NNS cord-023134-y665agnh 743 11 which which WDT cord-023134-y665agnh 743 12 progressed progress VBD cord-023134-y665agnh 743 13 ( ( -LRB- cord-023134-y665agnh 743 14 n=40 n=40 JJ cord-023134-y665agnh 743 15 ) ) -RRB- cord-023134-y665agnh 743 16 and and CC cord-023134-y665agnh 743 17 6(0 6(0 NNP cord-023134-y665agnh 743 18 , , , cord-023134-y665agnh 743 19 14)% 14)% CD cord-023134-y665agnh 743 20 in in IN cord-023134-y665agnh 743 21 cats cat NNS cord-023134-y665agnh 743 22 with with IN cord-023134-y665agnh 743 23 stable stable JJ cord-023134-y665agnh 743 24 renal renal JJ cord-023134-y665agnh 743 25 function function NN cord-023134-y665agnh 743 26 in in IN cord-023134-y665agnh 743 27 the the DT cord-023134-y665agnh 743 28 year year NN cord-023134-y665agnh 743 29 following follow VBG cord-023134-y665agnh 743 30 diagnosis diagnosis NN cord-023134-y665agnh 743 31 ( ( -LRB- cord-023134-y665agnh 743 32 n=39 n=39 NNP cord-023134-y665agnh 743 33 ) ) -RRB- cord-023134-y665agnh 743 34 . . . cord-023134-y665agnh 744 1 UVC UVC NNP cord-023134-y665agnh 744 2 was be VBD cord-023134-y665agnh 744 3 also also RB cord-023134-y665agnh 744 4 associated associate VBN cord-023134-y665agnh 744 5 with with IN cord-023134-y665agnh 744 6 progression progression NN cord-023134-y665agnh 744 7 of of IN cord-023134-y665agnh 744 8 azotaemia azotaemia NN cord-023134-y665agnh 744 9 ( ( -LRB- cord-023134-y665agnh 744 10 p=0.008 p=0.008 NNP cord-023134-y665agnh 744 11 ) ) -RRB- cord-023134-y665agnh 744 12 independently independently RB cord-023134-y665agnh 744 13 of of IN cord-023134-y665agnh 744 14 UPC UPC NNP cord-023134-y665agnh 744 15 and and CC cord-023134-y665agnh 744 16 plasma plasma NN cord-023134-y665agnh 744 17 phosphate phosphate NN cord-023134-y665agnh 744 18 concentration concentration NN cord-023134-y665agnh 744 19 . . . cord-023134-y665agnh 745 1 The the DT cord-023134-y665agnh 745 2 progressive progressive JJ cord-023134-y665agnh 745 3 group group NN cord-023134-y665agnh 745 4 had have VBD cord-023134-y665agnh 745 5 UVC UVC NNP cord-023134-y665agnh 745 6 of of IN cord-023134-y665agnh 745 7 0.36(0.26 0.36(0.26 CD cord-023134-y665agnh 745 8 , , , cord-023134-y665agnh 745 9 0.54 0.54 CD cord-023134-y665agnh 745 10 ) ) -RRB- cord-023134-y665agnh 746 1 lg lg NNP cord-023134-y665agnh 746 2 / / SYM cord-023134-y665agnh 746 3 g g NNP cord-023134-y665agnh 746 4 , , , cord-023134-y665agnh 746 5 while while IN cord-023134-y665agnh 746 6 the the DT cord-023134-y665agnh 746 7 stable stable JJ cord-023134-y665agnh 746 8 group group NN cord-023134-y665agnh 746 9 had have VBD cord-023134-y665agnh 746 10 UVC UVC NNP cord-023134-y665agnh 746 11 of of IN cord-023134-y665agnh 746 12 0.26(0.20 0.26(0.20 CD cord-023134-y665agnh 746 13 , , , cord-023134-y665agnh 746 14 0.38 0.38 CD cord-023134-y665agnh 746 15 ) ) -RRB- cord-023134-y665agnh 747 1 lg lg NNP cord-023134-y665agnh 747 2 / / SYM cord-023134-y665agnh 747 3 g g NNP cord-023134-y665agnh 747 4 . . . cord-023134-y665agnh 748 1 If if IN cord-023134-y665agnh 748 2 high high JJ cord-023134-y665agnh 748 3 UVC UVC NNP cord-023134-y665agnh 748 4 indicates indicate VBZ cord-023134-y665agnh 748 5 renal renal JJ cord-023134-y665agnh 748 6 hypoxia hypoxia NN cord-023134-y665agnh 748 7 , , , cord-023134-y665agnh 748 8 the the DT cord-023134-y665agnh 748 9 results result NNS cord-023134-y665agnh 748 10 of of IN cord-023134-y665agnh 748 11 this this DT cord-023134-y665agnh 748 12 study study NN cord-023134-y665agnh 748 13 support support VBP cord-023134-y665agnh 748 14 the the DT cord-023134-y665agnh 748 15 hypothesis hypothesis NN cord-023134-y665agnh 748 16 that that IN cord-023134-y665agnh 748 17 hypoxia hypoxia NN cord-023134-y665agnh 748 18 is be VBZ cord-023134-y665agnh 748 19 associated associate VBN cord-023134-y665agnh 748 20 with with IN cord-023134-y665agnh 748 21 progression progression NN cord-023134-y665agnh 748 22 in in IN cord-023134-y665agnh 748 23 cats cat NNS cord-023134-y665agnh 748 24 with with IN cord-023134-y665agnh 748 25 CKD CKD NNP cord-023134-y665agnh 748 26 . . . cord-023134-y665agnh 749 1 However however RB cord-023134-y665agnh 749 2 , , , cord-023134-y665agnh 749 3 further further JJ cord-023134-y665agnh 749 4 studies study NNS cord-023134-y665agnh 749 5 evaluating evaluate VBG cord-023134-y665agnh 749 6 renal renal JJ cord-023134-y665agnh 749 7 hypoxia hypoxia NN cord-023134-y665agnh 749 8 directly directly RB cord-023134-y665agnh 749 9 would would MD cord-023134-y665agnh 749 10 be be VB cord-023134-y665agnh 749 11 required require VBN cord-023134-y665agnh 749 12 to to TO cord-023134-y665agnh 749 13 verify verify VB cord-023134-y665agnh 749 14 this this DT cord-023134-y665agnh 749 15 . . . cord-023134-y665agnh 750 1 The the DT cord-023134-y665agnh 750 2 term term NN cord-023134-y665agnh 750 3 ' ' `` cord-023134-y665agnh 750 4 triaditis triaditis NN cord-023134-y665agnh 750 5 ' ' '' cord-023134-y665agnh 750 6 is be VBZ cord-023134-y665agnh 750 7 used use VBN cord-023134-y665agnh 750 8 to to TO cord-023134-y665agnh 750 9 describe describe VB cord-023134-y665agnh 750 10 concurrent concurrent JJ cord-023134-y665agnh 750 11 inflammation inflammation NN cord-023134-y665agnh 750 12 of of IN cord-023134-y665agnh 750 13 the the DT cord-023134-y665agnh 750 14 liver liver NN cord-023134-y665agnh 750 15 , , , cord-023134-y665agnh 750 16 pancreas pancrea NNS cord-023134-y665agnh 750 17 , , , cord-023134-y665agnh 750 18 and and CC cord-023134-y665agnh 750 19 small small JJ cord-023134-y665agnh 750 20 intestine intestine NN cord-023134-y665agnh 750 21 , , , cord-023134-y665agnh 750 22 although although IN cord-023134-y665agnh 750 23 occasionally occasionally RB cord-023134-y665agnh 750 24 only only RB cord-023134-y665agnh 750 25 two two CD cord-023134-y665agnh 750 26 of of IN cord-023134-y665agnh 750 27 these these DT cord-023134-y665agnh 750 28 organs organ NNS cord-023134-y665agnh 750 29 may may MD cord-023134-y665agnh 750 30 participate participate VB cord-023134-y665agnh 750 31 . . . cord-023134-y665agnh 751 1 The the DT cord-023134-y665agnh 751 2 aim aim NN cord-023134-y665agnh 751 3 of of IN cord-023134-y665agnh 751 4 this this DT cord-023134-y665agnh 751 5 study study NN cord-023134-y665agnh 751 6 was be VBD cord-023134-y665agnh 751 7 to to TO cord-023134-y665agnh 751 8 investigate investigate VB cord-023134-y665agnh 751 9 the the DT cord-023134-y665agnh 751 10 frequency frequency NN cord-023134-y665agnh 751 11 of of IN cord-023134-y665agnh 751 12 coexistence coexistence NN cord-023134-y665agnh 751 13 of of IN cord-023134-y665agnh 751 14 different different JJ cord-023134-y665agnh 751 15 combinations combination NNS cord-023134-y665agnh 751 16 of of IN cord-023134-y665agnh 751 17 cholangitis cholangitis NN cord-023134-y665agnh 751 18 , , , cord-023134-y665agnh 751 19 pancreatitis pancreatitis NN cord-023134-y665agnh 751 20 and/or and/or CC cord-023134-y665agnh 751 21 inflammatory inflammatory JJ cord-023134-y665agnh 751 22 bowel bowel NN cord-023134-y665agnh 751 23 disease disease NN cord-023134-y665agnh 751 24 in in IN cord-023134-y665agnh 751 25 cats cat NNS cord-023134-y665agnh 751 26 , , , cord-023134-y665agnh 751 27 and and CC cord-023134-y665agnh 751 28 describe describe VB cord-023134-y665agnh 751 29 the the DT cord-023134-y665agnh 751 30 clinical clinical JJ cord-023134-y665agnh 751 31 , , , cord-023134-y665agnh 751 32 clinicopathological clinicopathological JJ cord-023134-y665agnh 751 33 , , , cord-023134-y665agnh 751 34 and and CC cord-023134-y665agnh 751 35 histopathological histopathological NNP cord-023134-y665agnh 751 36 findings finding NNS cord-023134-y665agnh 751 37 . . . cord-023134-y665agnh 752 1 Initially initially RB cord-023134-y665agnh 752 2 67 67 CD cord-023134-y665agnh 752 3 cats cat NNS cord-023134-y665agnh 752 4 were be VBD cord-023134-y665agnh 752 5 included include VBN cord-023134-y665agnh 752 6 in in IN cord-023134-y665agnh 752 7 the the DT cord-023134-y665agnh 752 8 study study NN cord-023134-y665agnh 752 9 . . . cord-023134-y665agnh 753 1 Thirty thirty CD cord-023134-y665agnh 753 2 - - HYPH cord-023134-y665agnh 753 3 nine nine CD cord-023134-y665agnh 753 4 cats cat NNS cord-023134-y665agnh 753 5 had have VBD cord-023134-y665agnh 753 6 a a DT cord-023134-y665agnh 753 7 suspicion suspicion NN cord-023134-y665agnh 753 8 of of IN cord-023134-y665agnh 753 9 ' ' `` cord-023134-y665agnh 753 10 triaditis triaditis NN cord-023134-y665agnh 753 11 ' ' '' cord-023134-y665agnh 753 12 based base VBN cord-023134-y665agnh 753 13 on on IN cord-023134-y665agnh 753 14 clinical clinical JJ cord-023134-y665agnh 753 15 signs sign NNS cord-023134-y665agnh 753 16 ( ( -LRB- cord-023134-y665agnh 753 17 depression depression NN cord-023134-y665agnh 753 18 , , , cord-023134-y665agnh 753 19 anorexia anorexia NN cord-023134-y665agnh 753 20 or or CC cord-023134-y665agnh 753 21 polyphagia polyphagia NN cord-023134-y665agnh 753 22 , , , cord-023134-y665agnh 753 23 vomiting vomiting NN cord-023134-y665agnh 753 24 , , , cord-023134-y665agnh 753 25 diarrhea diarrhea NN cord-023134-y665agnh 753 26 , , , cord-023134-y665agnh 753 27 and/or and/or CC cord-023134-y665agnh 753 28 weight weight NN cord-023134-y665agnh 753 29 loss loss NN cord-023134-y665agnh 753 30 ) ) -RRB- cord-023134-y665agnh 753 31 , , , cord-023134-y665agnh 753 32 while while IN cord-023134-y665agnh 753 33 28 28 CD cord-023134-y665agnh 753 34 cats cat NNS cord-023134-y665agnh 753 35 clinically clinically RB cord-023134-y665agnh 753 36 healthy healthy JJ cord-023134-y665agnh 753 37 , , , cord-023134-y665agnh 753 38 were be VBD cord-023134-y665agnh 753 39 considered consider VBN cord-023134-y665agnh 753 40 as as IN cord-023134-y665agnh 753 41 controls control NNS cord-023134-y665agnh 753 42 . . . cord-023134-y665agnh 754 1 Each each DT cord-023134-y665agnh 754 2 cat cat NN cord-023134-y665agnh 754 3 on on IN cord-023134-y665agnh 754 4 presentation presentation NN cord-023134-y665agnh 754 5 underwent undergo VBD cord-023134-y665agnh 754 6 CBC CBC NNP cord-023134-y665agnh 754 7 , , , cord-023134-y665agnh 754 8 biochemistry biochemistry NN cord-023134-y665agnh 754 9 profile profile NN cord-023134-y665agnh 754 10 , , , cord-023134-y665agnh 754 11 serum serum NN cord-023134-y665agnh 754 12 total total JJ cord-023134-y665agnh 754 13 T4 T4 NNP cord-023134-y665agnh 754 14 , , , cord-023134-y665agnh 754 15 Spec Spec NNP cord-023134-y665agnh 754 16 fPL fPL NNP cord-023134-y665agnh 754 17 ® ® VBP cord-023134-y665agnh 754 18 and and CC cord-023134-y665agnh 754 19 fTLI ftli VB cord-023134-y665agnh 754 20 blood blood NN cord-023134-y665agnh 754 21 examinations examination NNS cord-023134-y665agnh 754 22 . . . cord-023134-y665agnh 755 1 Cats cat NNS cord-023134-y665agnh 755 2 diagnosed diagnose VBD cord-023134-y665agnh 755 3 with with IN cord-023134-y665agnh 755 4 intestinal intestinal JJ cord-023134-y665agnh 755 5 parasitism parasitism NN cord-023134-y665agnh 755 6 , , , cord-023134-y665agnh 755 7 infectious infectious JJ cord-023134-y665agnh 755 8 disease disease NN cord-023134-y665agnh 755 9 , , , cord-023134-y665agnh 755 10 neoplasia neoplasia NN cord-023134-y665agnh 755 11 , , , cord-023134-y665agnh 755 12 and/or and/or CC cord-023134-y665agnh 755 13 hyperthyroidism hyperthyroidism NN cord-023134-y665agnh 755 14 were be VBD cord-023134-y665agnh 755 15 excluded exclude VBN cord-023134-y665agnh 755 16 from from IN cord-023134-y665agnh 755 17 the the DT cord-023134-y665agnh 755 18 study study NN cord-023134-y665agnh 755 19 . . . cord-023134-y665agnh 756 1 Biopsies biopsy NNS cord-023134-y665agnh 756 2 from from IN cord-023134-y665agnh 756 3 the the DT cord-023134-y665agnh 756 4 liver liver NN cord-023134-y665agnh 756 5 , , , cord-023134-y665agnh 756 6 pancreas pancreas NN cord-023134-y665agnh 756 7 and and CC cord-023134-y665agnh 756 8 small small JJ cord-023134-y665agnh 756 9 intestine intestine NN cord-023134-y665agnh 756 10 ( ( -LRB- cord-023134-y665agnh 756 11 duodenum duodenum NN cord-023134-y665agnh 756 12 , , , cord-023134-y665agnh 756 13 jejunum jejunum NNS cord-023134-y665agnh 756 14 , , , cord-023134-y665agnh 756 15 and and CC cord-023134-y665agnh 756 16 ileum ileum NN cord-023134-y665agnh 756 17 ) ) -RRB- cord-023134-y665agnh 756 18 were be VBD cord-023134-y665agnh 756 19 collected collect VBN cord-023134-y665agnh 756 20 from from IN cord-023134-y665agnh 756 21 each each DT cord-023134-y665agnh 756 22 sick sick JJ cord-023134-y665agnh 756 23 cat cat NN cord-023134-y665agnh 756 24 during during IN cord-023134-y665agnh 756 25 laparotomy laparotomy NN cord-023134-y665agnh 756 26 as as IN cord-023134-y665agnh 756 27 part part NN cord-023134-y665agnh 756 28 of of IN cord-023134-y665agnh 756 29 the the DT cord-023134-y665agnh 756 30 diagnostic diagnostic JJ cord-023134-y665agnh 756 31 investigation investigation NN cord-023134-y665agnh 756 32 . . . cord-023134-y665agnh 757 1 Biopsies biopsy NNS cord-023134-y665agnh 757 2 from from IN cord-023134-y665agnh 757 3 healthy healthy JJ cord-023134-y665agnh 757 4 cats cat NNS cord-023134-y665agnh 757 5 were be VBD cord-023134-y665agnh 757 6 collected collect VBN cord-023134-y665agnh 757 7 during during IN cord-023134-y665agnh 757 8 laparotomy laparotomy NN cord-023134-y665agnh 757 9 for for IN cord-023134-y665agnh 757 10 ovariohysterectomy ovariohysterectomy NN cord-023134-y665agnh 757 11 . . . cord-023134-y665agnh 758 1 All all DT cord-023134-y665agnh 758 2 owners owner NNS cord-023134-y665agnh 758 3 had have VBD cord-023134-y665agnh 758 4 signed sign VBN cord-023134-y665agnh 758 5 a a DT cord-023134-y665agnh 758 6 consent consent NN cord-023134-y665agnh 758 7 form form NN cord-023134-y665agnh 758 8 and and CC cord-023134-y665agnh 758 9 the the DT cord-023134-y665agnh 758 10 study study NN cord-023134-y665agnh 758 11 protocol protocol NN cord-023134-y665agnh 758 12 was be VBD cord-023134-y665agnh 758 13 approved approve VBN cord-023134-y665agnh 758 14 by by IN cord-023134-y665agnh 758 15 the the DT cord-023134-y665agnh 758 16 University University NNP cord-023134-y665agnh 758 17 's 's POS cord-023134-y665agnh 758 18 and and CC cord-023134-y665agnh 758 19 State State NNP cord-023134-y665agnh 758 20 's 's POS cord-023134-y665agnh 758 21 Ethics Ethics NNP cord-023134-y665agnh 758 22 Committee Committee NNP cord-023134-y665agnh 758 23 . . . cord-023134-y665agnh 759 1 Of of IN cord-023134-y665agnh 759 2 the the DT cord-023134-y665agnh 759 3 39 39 CD cord-023134-y665agnh 759 4 sick sick JJ cord-023134-y665agnh 759 5 cats cat NNS cord-023134-y665agnh 759 6 with with IN cord-023134-y665agnh 759 7 a a DT cord-023134-y665agnh 759 8 suspicion suspicion NN cord-023134-y665agnh 759 9 of of IN cord-023134-y665agnh 759 10 triaditis triaditis NNP cord-023134-y665agnh 759 11 , , , cord-023134-y665agnh 759 12 12 12 CD cord-023134-y665agnh 759 13 were be VBD cord-023134-y665agnh 759 14 excluded exclude VBN cord-023134-y665agnh 759 15 because because IN cord-023134-y665agnh 759 16 of of IN cord-023134-y665agnh 759 17 neoplasia neoplasia NN cord-023134-y665agnh 759 18 or or CC cord-023134-y665agnh 759 19 other other JJ cord-023134-y665agnh 759 20 conditions condition NNS cord-023134-y665agnh 759 21 . . . cord-023134-y665agnh 760 1 Of of IN cord-023134-y665agnh 760 2 the the DT cord-023134-y665agnh 760 3 28 28 CD cord-023134-y665agnh 760 4 clinically clinically RB cord-023134-y665agnh 760 5 healthy healthy JJ cord-023134-y665agnh 760 6 cats cat NNS cord-023134-y665agnh 760 7 , , , cord-023134-y665agnh 760 8 20 20 CD cord-023134-y665agnh 760 9 had have VBD cord-023134-y665agnh 760 10 histopathological histopathological JJ cord-023134-y665agnh 760 11 evidence evidence NN cord-023134-y665agnh 760 12 of of IN cord-023134-y665agnh 760 13 inflammation inflammation NN cord-023134-y665agnh 760 14 in in IN cord-023134-y665agnh 760 15 their -PRON- PRP$ cord-023134-y665agnh 760 16 liver liver NN cord-023134-y665agnh 760 17 , , , cord-023134-y665agnh 760 18 pancreas pancrea NNS cord-023134-y665agnh 760 19 , , , cord-023134-y665agnh 760 20 and/or and/or CC cord-023134-y665agnh 760 21 intestine intestine NN cord-023134-y665agnh 760 22 and and CC cord-023134-y665agnh 760 23 were be VBD cord-023134-y665agnh 760 24 eventually eventually RB cord-023134-y665agnh 760 25 grouped group VBN cord-023134-y665agnh 760 26 together together RB cord-023134-y665agnh 760 27 with with IN cord-023134-y665agnh 760 28 the the DT cord-023134-y665agnh 760 29 sick sick JJ cord-023134-y665agnh 760 30 cats cat NNS cord-023134-y665agnh 760 31 . . . cord-023134-y665agnh 761 1 Collectively collectively RB cord-023134-y665agnh 761 2 , , , cord-023134-y665agnh 761 3 histopathological histopathological JJ cord-023134-y665agnh 761 4 evaluation evaluation NN cord-023134-y665agnh 761 5 of of IN cord-023134-y665agnh 761 6 the the DT cord-023134-y665agnh 761 7 biopsies biopsy NNS cord-023134-y665agnh 761 8 revealed reveal VBD cord-023134-y665agnh 761 9 47 47 CD cord-023134-y665agnh 761 10 cats cat NNS cord-023134-y665agnh 761 11 ( ( -LRB- cord-023134-y665agnh 761 12 27 27 CD cord-023134-y665agnh 761 13 with with IN cord-023134-y665agnh 761 14 clinical clinical JJ cord-023134-y665agnh 761 15 signs sign NNS cord-023134-y665agnh 761 16 and and CC cord-023134-y665agnh 761 17 20 20 CD cord-023134-y665agnh 761 18 without without IN cord-023134-y665agnh 761 19 ) ) -RRB- cord-023134-y665agnh 761 20 with with IN cord-023134-y665agnh 761 21 inflammatory inflammatory JJ cord-023134-y665agnh 761 22 lesions lesion NNS cord-023134-y665agnh 761 23 in in IN cord-023134-y665agnh 761 24 at at RB cord-023134-y665agnh 761 25 least least RBS cord-023134-y665agnh 761 26 one one CD cord-023134-y665agnh 761 27 organ organ NN cord-023134-y665agnh 761 28 . . . cord-023134-y665agnh 762 1 Of of IN cord-023134-y665agnh 762 2 those those DT cord-023134-y665agnh 762 3 47 47 CD cord-023134-y665agnh 762 4 cats cat NNS cord-023134-y665agnh 762 5 , , , cord-023134-y665agnh 762 6 40 40 CD cord-023134-y665agnh 762 7 ( ( -LRB- cord-023134-y665agnh 762 8 85.1 85.1 CD cord-023134-y665agnh 762 9 % % NN cord-023134-y665agnh 762 10 ) ) -RRB- cord-023134-y665agnh 762 11 had have VBD cord-023134-y665agnh 762 12 histopathological histopathological JJ cord-023134-y665agnh 762 13 evidence evidence NN cord-023134-y665agnh 762 14 of of IN cord-023134-y665agnh 762 15 IBD IBD NNP cord-023134-y665agnh 762 16 , , , cord-023134-y665agnh 762 17 30 30 CD cord-023134-y665agnh 762 18 ( ( -LRB- cord-023134-y665agnh 762 19 63.8 63.8 CD cord-023134-y665agnh 762 20 % % NN cord-023134-y665agnh 762 21 ) ) -RRB- cord-023134-y665agnh 762 22 of of IN cord-023134-y665agnh 762 23 cholangitis cholangitis NN cord-023134-y665agnh 762 24 , , , cord-023134-y665agnh 762 25 and and CC cord-023134-y665agnh 762 26 12 12 CD cord-023134-y665agnh 762 27 ( ( -LRB- cord-023134-y665agnh 762 28 25.5 25.5 CD cord-023134-y665agnh 762 29 % % NN cord-023134-y665agnh 762 30 ) ) -RRB- cord-023134-y665agnh 762 31 of of IN cord-023134-y665agnh 762 32 pancreatitis pancreatitis NN cord-023134-y665agnh 762 33 . . . cord-023134-y665agnh 763 1 Thirteen thirteen CD cord-023134-y665agnh 763 2 cats cat NNS cord-023134-y665agnh 763 3 ( ( -LRB- cord-023134-y665agnh 763 4 27.6 27.6 CD cord-023134-y665agnh 763 5 % % NN cord-023134-y665agnh 763 6 ) ) -RRB- cord-023134-y665agnh 763 7 had have VBD cord-023134-y665agnh 763 8 only only RB cord-023134-y665agnh 763 9 IBD IBD NNP cord-023134-y665agnh 763 10 , , , cord-023134-y665agnh 763 11 8 8 CD cord-023134-y665agnh 763 12 ( ( -LRB- cord-023134-y665agnh 763 13 61.5 61.5 CD cord-023134-y665agnh 763 14 % % NN cord-023134-y665agnh 763 15 ) ) -RRB- cord-023134-y665agnh 763 16 of of IN cord-023134-y665agnh 763 17 which which WDT cord-023134-y665agnh 763 18 were be VBD cord-023134-y665agnh 763 19 symptomatic symptomatic JJ cord-023134-y665agnh 763 20 . . . cord-023134-y665agnh 764 1 Six six CD cord-023134-y665agnh 764 2 ( ( -LRB- cord-023134-y665agnh 764 3 12.7 12.7 CD cord-023134-y665agnh 764 4 % % NN cord-023134-y665agnh 764 5 ) ) -RRB- cord-023134-y665agnh 764 6 cats cat NNS cord-023134-y665agnh 764 7 had have VBD cord-023134-y665agnh 764 8 only only RB cord-023134-y665agnh 764 9 cholangitis cholangitis NN cord-023134-y665agnh 764 10 , , , cord-023134-y665agnh 764 11 2 2 CD cord-023134-y665agnh 764 12 ( ( -LRB- cord-023134-y665agnh 764 13 33.3 33.3 CD cord-023134-y665agnh 764 14 % % NN cord-023134-y665agnh 764 15 ) ) -RRB- cord-023134-y665agnh 764 16 of of IN cord-023134-y665agnh 764 17 which which WDT cord-023134-y665agnh 764 18 were be VBD cord-023134-y665agnh 764 19 symptomatic symptomatic JJ cord-023134-y665agnh 764 20 . . . cord-023134-y665agnh 765 1 One one CD cord-023134-y665agnh 765 2 ( ( -LRB- cord-023134-y665agnh 765 3 2.1 2.1 CD cord-023134-y665agnh 765 4 % % NN cord-023134-y665agnh 765 5 ) ) -RRB- cord-023134-y665agnh 765 6 had have VBD cord-023134-y665agnh 765 7 only only RB cord-023134-y665agnh 765 8 pancreatitis pancreatitis NN cord-023134-y665agnh 765 9 and and CC cord-023134-y665agnh 765 10 was be VBD cord-023134-y665agnh 765 11 symptomatic symptomatic JJ cord-023134-y665agnh 765 12 . . . cord-023134-y665agnh 766 1 Sixteen sixteen CD cord-023134-y665agnh 766 2 cats cat NNS cord-023134-y665agnh 766 3 ( ( -LRB- cord-023134-y665agnh 766 4 34 34 CD cord-023134-y665agnh 766 5 % % NN cord-023134-y665agnh 766 6 ) ) -RRB- cord-023134-y665agnh 766 7 had have VBD cord-023134-y665agnh 766 8 concurrent concurrent JJ cord-023134-y665agnh 766 9 IBD IBD NNP cord-023134-y665agnh 766 10 and and CC cord-023134-y665agnh 766 11 cholangitis cholangitis NN cord-023134-y665agnh 766 12 , , , cord-023134-y665agnh 766 13 6 6 CD cord-023134-y665agnh 766 14 ( ( -LRB- cord-023134-y665agnh 766 15 37.5 37.5 CD cord-023134-y665agnh 766 16 % % NN cord-023134-y665agnh 766 17 ) ) -RRB- cord-023134-y665agnh 766 18 of of IN cord-023134-y665agnh 766 19 which which WDT cord-023134-y665agnh 766 20 were be VBD cord-023134-y665agnh 766 21 symptomatic symptomatic JJ cord-023134-y665agnh 766 22 ; ; : cord-023134-y665agnh 766 23 3 3 CD cord-023134-y665agnh 766 24 ( ( -LRB- cord-023134-y665agnh 766 25 6.4 6.4 CD cord-023134-y665agnh 766 26 % % NN cord-023134-y665agnh 766 27 ) ) -RRB- cord-023134-y665agnh 766 28 had have VBD cord-023134-y665agnh 766 29 IBD IBD NNP cord-023134-y665agnh 766 30 in in IN cord-023134-y665agnh 766 31 combination combination NN cord-023134-y665agnh 766 32 with with IN cord-023134-y665agnh 766 33 pancreatitis pancreatitis NN cord-023134-y665agnh 766 34 , , , cord-023134-y665agnh 766 35 2 2 CD cord-023134-y665agnh 766 36 ( ( -LRB- cord-023134-y665agnh 766 37 66.7 66.7 CD cord-023134-y665agnh 766 38 % % NN cord-023134-y665agnh 766 39 ) ) -RRB- cord-023134-y665agnh 766 40 of of IN cord-023134-y665agnh 766 41 which which WDT cord-023134-y665agnh 766 42 were be VBD cord-023134-y665agnh 766 43 symptomatic symptomatic JJ cord-023134-y665agnh 766 44 , , , cord-023134-y665agnh 766 45 while while IN cord-023134-y665agnh 766 46 8 8 CD cord-023134-y665agnh 766 47 ( ( -LRB- cord-023134-y665agnh 766 48 17 17 CD cord-023134-y665agnh 766 49 % % NN cord-023134-y665agnh 766 50 ) ) -RRB- cord-023134-y665agnh 766 51 had have VBD cord-023134-y665agnh 766 52 IBD IBD NNP cord-023134-y665agnh 766 53 , , , cord-023134-y665agnh 766 54 cholangitis cholangitis NN cord-023134-y665agnh 766 55 and and CC cord-023134-y665agnh 766 56 pancreatitis pancreatitis NN cord-023134-y665agnh 766 57 and and CC cord-023134-y665agnh 766 58 were be VBD cord-023134-y665agnh 766 59 all all DT cord-023134-y665agnh 766 60 symptomatic symptomatic JJ cord-023134-y665agnh 766 61 . . . cord-023134-y665agnh 767 1 Common common JJ cord-023134-y665agnh 767 2 biochemical biochemical JJ cord-023134-y665agnh 767 3 findings finding NNS cord-023134-y665agnh 767 4 were be VBD cord-023134-y665agnh 767 5 increased increase VBN cord-023134-y665agnh 767 6 activities activity NNS cord-023134-y665agnh 767 7 of of IN cord-023134-y665agnh 767 8 ALT alt NN cord-023134-y665agnh 767 9 ( ( -LRB- cord-023134-y665agnh 767 10 11/47 11/47 CD cord-023134-y665agnh 767 11 ) ) -RRB- cord-023134-y665agnh 767 12 , , , cord-023134-y665agnh 767 13 ALP ALP NNP cord-023134-y665agnh 767 14 ( ( -LRB- cord-023134-y665agnh 767 15 11/47 11/47 CD cord-023134-y665agnh 767 16 ) ) -RRB- cord-023134-y665agnh 767 17 , , , cord-023134-y665agnh 767 18 and and CC cord-023134-y665agnh 767 19 increased increase VBD cord-023134-y665agnh 767 20 total total JJ cord-023134-y665agnh 767 21 bilirubin bilirubin NN cord-023134-y665agnh 767 22 ( ( -LRB- cord-023134-y665agnh 767 23 14/ 14/ CD cord-023134-y665agnh 767 24 47 47 CD cord-023134-y665agnh 767 25 ) ) -RRB- cord-023134-y665agnh 767 26 , , , cord-023134-y665agnh 767 27 fTLI ftli ADD cord-023134-y665agnh 767 28 ( ( -LRB- cord-023134-y665agnh 767 29 3/47 3/47 CD cord-023134-y665agnh 767 30 ) ) -RRB- cord-023134-y665agnh 767 31 , , , cord-023134-y665agnh 767 32 Spec Spec NNP cord-023134-y665agnh 767 33 fPL fPL NNP cord-023134-y665agnh 767 34 ( ( -LRB- cord-023134-y665agnh 767 35 12/47 12/47 CD cord-023134-y665agnh 767 36 ) ) -RRB- cord-023134-y665agnh 767 37 concentrations concentration NNS cord-023134-y665agnh 767 38 . . . cord-023134-y665agnh 768 1 The the DT cord-023134-y665agnh 768 2 results result NNS cord-023134-y665agnh 768 3 of of IN cord-023134-y665agnh 768 4 our -PRON- PRP$ cord-023134-y665agnh 768 5 study study NN cord-023134-y665agnh 768 6 indicate indicate VBP cord-023134-y665agnh 768 7 that that IN cord-023134-y665agnh 768 8 different different JJ cord-023134-y665agnh 768 9 combinations combination NNS cord-023134-y665agnh 768 10 of of IN cord-023134-y665agnh 768 11 concurrent concurrent JJ cord-023134-y665agnh 768 12 inflammation inflammation NN cord-023134-y665agnh 768 13 of of IN cord-023134-y665agnh 768 14 the the DT cord-023134-y665agnh 768 15 liver liver NN cord-023134-y665agnh 768 16 , , , cord-023134-y665agnh 768 17 pancreas pancrea NNS cord-023134-y665agnh 768 18 , , , cord-023134-y665agnh 768 19 and and CC cord-023134-y665agnh 768 20 intestine intestine NN cord-023134-y665agnh 768 21 do do VBP cord-023134-y665agnh 768 22 exist exist VB cord-023134-y665agnh 768 23 in in IN cord-023134-y665agnh 768 24 cats cat NNS cord-023134-y665agnh 768 25 . . . cord-023134-y665agnh 769 1 It -PRON- PRP cord-023134-y665agnh 769 2 also also RB cord-023134-y665agnh 769 3 appears appear VBZ cord-023134-y665agnh 769 4 that that IN cord-023134-y665agnh 769 5 these these DT cord-023134-y665agnh 769 6 conditions condition NNS cord-023134-y665agnh 769 7 may may MD cord-023134-y665agnh 769 8 be be VB cord-023134-y665agnh 769 9 subclinical subclinical JJ cord-023134-y665agnh 769 10 in in IN cord-023134-y665agnh 769 11 many many JJ cord-023134-y665agnh 769 12 cases case NNS cord-023134-y665agnh 769 13 . . . cord-023134-y665agnh 770 1 Several several JJ cord-023134-y665agnh 770 2 potential potential JJ cord-023134-y665agnh 770 3 pathogens pathogen NNS cord-023134-y665agnh 770 4 are be VBP cord-023134-y665agnh 770 5 found find VBN cord-023134-y665agnh 770 6 in in IN cord-023134-y665agnh 770 7 feline feline JJ cord-023134-y665agnh 770 8 faeces faece NNS cord-023134-y665agnh 770 9 , , , cord-023134-y665agnh 770 10 ranging range VBG cord-023134-y665agnh 770 11 in in IN cord-023134-y665agnh 770 12 significance significance NN cord-023134-y665agnh 770 13 from from IN cord-023134-y665agnh 770 14 incidental incidental JJ cord-023134-y665agnh 770 15 to to IN cord-023134-y665agnh 770 16 pathogenic pathogenic JJ cord-023134-y665agnh 770 17 . . . cord-023134-y665agnh 771 1 Treatment treatment NN cord-023134-y665agnh 771 2 recommendations recommendation NNS cord-023134-y665agnh 771 3 are be VBP cord-023134-y665agnh 771 4 based base VBN cord-023134-y665agnh 771 5 on on IN cord-023134-y665agnh 771 6 accompanying accompany VBG cord-023134-y665agnh 771 7 clinical clinical JJ cord-023134-y665agnh 771 8 signs sign NNS cord-023134-y665agnh 771 9 . . . cord-023134-y665agnh 772 1 Real real JJ cord-023134-y665agnh 772 2 Time Time NNP cord-023134-y665agnh 772 3 PCR PCR NNP cord-023134-y665agnh 772 4 has have VBZ cord-023134-y665agnh 772 5 enabled enable VBN cord-023134-y665agnh 772 6 rapid rapid JJ cord-023134-y665agnh 772 7 screening screening NN cord-023134-y665agnh 772 8 of of IN cord-023134-y665agnh 772 9 small small JJ cord-023134-y665agnh 772 10 quantities quantity NNS cord-023134-y665agnh 772 11 of of IN cord-023134-y665agnh 772 12 faeces faece NNS cord-023134-y665agnh 772 13 for for IN cord-023134-y665agnh 772 14 potential potential JJ cord-023134-y665agnh 772 15 pathogens pathogen NNS cord-023134-y665agnh 772 16 , , , cord-023134-y665agnh 772 17 with with IN cord-023134-y665agnh 772 18 high high JJ cord-023134-y665agnh 772 19 sensitivity sensitivity NN cord-023134-y665agnh 772 20 and and CC cord-023134-y665agnh 772 21 specificity specificity NN cord-023134-y665agnh 772 22 . . . cord-023134-y665agnh 773 1 Co co NN cord-023134-y665agnh 773 2 - - NN cord-023134-y665agnh 773 3 carriage carriage NN cord-023134-y665agnh 773 4 of of IN cord-023134-y665agnh 773 5 feline feline JJ cord-023134-y665agnh 773 6 faecal faecal JJ cord-023134-y665agnh 773 7 pathogens pathogen NNS cord-023134-y665agnh 773 8 may may MD cord-023134-y665agnh 773 9 reflect reflect VB cord-023134-y665agnh 773 10 a a DT cord-023134-y665agnh 773 11 symbiotic symbiotic JJ cord-023134-y665agnh 773 12 relationship relationship NN cord-023134-y665agnh 773 13 or or CC cord-023134-y665agnh 773 14 related related JJ cord-023134-y665agnh 773 15 pathogenesis pathogenesis NN cord-023134-y665agnh 773 16 , , , cord-023134-y665agnh 773 17 in in IN cord-023134-y665agnh 773 18 which which WDT cord-023134-y665agnh 773 19 case case NN cord-023134-y665agnh 773 20 identification identification NN cord-023134-y665agnh 773 21 of of IN cord-023134-y665agnh 773 22 common common JJ cord-023134-y665agnh 773 23 cocarriage cocarriage NN cord-023134-y665agnh 773 24 patterns pattern NNS cord-023134-y665agnh 773 25 may may MD cord-023134-y665agnh 773 26 influence influence VB cord-023134-y665agnh 773 27 treatment treatment NN cord-023134-y665agnh 773 28 decisions decision NNS cord-023134-y665agnh 773 29 and and CC cord-023134-y665agnh 773 30 prognosis prognosis NN cord-023134-y665agnh 773 31 . . . cord-023134-y665agnh 774 1 The the DT cord-023134-y665agnh 774 2 primary primary JJ cord-023134-y665agnh 774 3 objective objective NN cord-023134-y665agnh 774 4 of of IN cord-023134-y665agnh 774 5 this this DT cord-023134-y665agnh 774 6 study study NN cord-023134-y665agnh 774 7 was be VBD cord-023134-y665agnh 774 8 to to TO cord-023134-y665agnh 774 9 identify identify VB cord-023134-y665agnh 774 10 co co NN cord-023134-y665agnh 774 11 - - NN cord-023134-y665agnh 774 12 carriage carriage NN cord-023134-y665agnh 774 13 of of IN cord-023134-y665agnh 774 14 selected select VBN cord-023134-y665agnh 774 15 feline feline JJ cord-023134-y665agnh 774 16 faecal faecal JJ cord-023134-y665agnh 774 17 pathogens pathogen NNS cord-023134-y665agnh 774 18 . . . cord-023134-y665agnh 775 1 Secondary secondary JJ cord-023134-y665agnh 775 2 objectives objective NNS cord-023134-y665agnh 775 3 were be VBD cord-023134-y665agnh 775 4 to to TO cord-023134-y665agnh 775 5 evaluate evaluate VB cord-023134-y665agnh 775 6 the the DT cord-023134-y665agnh 775 7 prevalence prevalence NN cord-023134-y665agnh 775 8 of of IN cord-023134-y665agnh 775 9 individual individual JJ cord-023134-y665agnh 775 10 pathogens pathogen NNS cord-023134-y665agnh 775 11 in in IN cord-023134-y665agnh 775 12 feline feline JJ cord-023134-y665agnh 775 13 faeces faece NNS cord-023134-y665agnh 775 14 , , , cord-023134-y665agnh 775 15 and and CC cord-023134-y665agnh 775 16 their -PRON- PRP$ cord-023134-y665agnh 775 17 association association NN cord-023134-y665agnh 775 18 with with IN cord-023134-y665agnh 775 19 pedigree pedigree NN cord-023134-y665agnh 775 20 status status NN cord-023134-y665agnh 775 21 , , , cord-023134-y665agnh 775 22 and and CC cord-023134-y665agnh 775 23 a a DT cord-023134-y665agnh 775 24 history history NN cord-023134-y665agnh 775 25 of of IN cord-023134-y665agnh 775 26 diarrhoea diarrhoea NN cord-023134-y665agnh 775 27 . . . cord-023134-y665agnh 776 1 Results result NNS cord-023134-y665agnh 776 2 of of IN cord-023134-y665agnh 776 3 a a DT cord-023134-y665agnh 776 4 commercial commercial JJ cord-023134-y665agnh 776 5 8-way 8-way JJ cord-023134-y665agnh 776 6 Feline feline JJ cord-023134-y665agnh 776 7 Diarrhoea diarrhoea NN cord-023134-y665agnh 776 8 RealPCR RealPCR NNP cord-023134-y665agnh 776 9 TM TM NNP cord-023134-y665agnh 776 10 Panel Panel NNP cord-023134-y665agnh 776 11 ( ( -LRB- cord-023134-y665agnh 776 12 Idexx Idexx NNP cord-023134-y665agnh 776 13 Reference Reference NNP cord-023134-y665agnh 776 14 Laboratories Laboratories NNP cord-023134-y665agnh 776 15 , , , cord-023134-y665agnh 776 16 UK UK NNP cord-023134-y665agnh 776 17 ) ) -RRB- cord-023134-y665agnh 776 18 from from IN cord-023134-y665agnh 776 19 June June NNP cord-023134-y665agnh 776 20 2010 2010 CD cord-023134-y665agnh 776 21 to to IN cord-023134-y665agnh 776 22 January January NNP cord-023134-y665agnh 776 23 2012 2012 CD cord-023134-y665agnh 776 24 were be VBD cord-023134-y665agnh 776 25 evaluated evaluate VBN cord-023134-y665agnh 776 26 . . . cord-023134-y665agnh 777 1 Real real JJ cord-023134-y665agnh 777 2 Time Time NNP cord-023134-y665agnh 777 3 PCR PCR NNP cord-023134-y665agnh 777 4 was be VBD cord-023134-y665agnh 777 5 performed perform VBN cord-023134-y665agnh 777 6 for for IN cord-023134-y665agnh 777 7 Tritrichomonas Tritrichomonas NNP cord-023134-y665agnh 777 8 foetus foetus NN cord-023134-y665agnh 777 9 , , , cord-023134-y665agnh 777 10 Giardiaspp Giardiaspp NNP cord-023134-y665agnh 777 11 . . NNP cord-023134-y665agnh 777 12 , , , cord-023134-y665agnh 777 13 Cryptosporidiumspp Cryptosporidiumspp NNP cord-023134-y665agnh 777 14 . . . cord-023134-y665agnh 778 1 , , , cord-023134-y665agnh 778 2 Toxoplasmagondii Toxoplasmagondii NNP cord-023134-y665agnh 778 3 , , , cord-023134-y665agnh 778 4 Salmonellaspp Salmonellaspp NNP cord-023134-y665agnh 778 5 . . NNP cord-023134-y665agnh 778 6 , , , cord-023134-y665agnh 778 7 Clostridium clostridium NN cord-023134-y665agnh 778 8 perfringens perfringens NN cord-023134-y665agnh 778 9 enterotoxin enterotoxin NNP cord-023134-y665agnh 778 10 A a DT cord-023134-y665agnh 778 11 gene gene NN cord-023134-y665agnh 778 12 , , , cord-023134-y665agnh 778 13 feline feline JJ cord-023134-y665agnh 778 14 coronavirus coronavirus NN cord-023134-y665agnh 778 15 , , , cord-023134-y665agnh 778 16 and and CC cord-023134-y665agnh 778 17 feline feline JJ cord-023134-y665agnh 778 18 panleukopenia panleukopenia NNP cord-023134-y665agnh 778 19 virus virus NN cord-023134-y665agnh 778 20 . . . cord-023134-y665agnh 779 1 Additional additional JJ cord-023134-y665agnh 779 2 data datum NNS cord-023134-y665agnh 779 3 was be VBD cord-023134-y665agnh 779 4 recorded record VBN cord-023134-y665agnh 779 5 when when WRB cord-023134-y665agnh 779 6 available available JJ cord-023134-y665agnh 779 7 , , , cord-023134-y665agnh 779 8 including include VBG cord-023134-y665agnh 779 9 age age NN cord-023134-y665agnh 779 10 , , , cord-023134-y665agnh 779 11 gender gender NN cord-023134-y665agnh 779 12 , , , cord-023134-y665agnh 779 13 breed breed NN cord-023134-y665agnh 779 14 , , , cord-023134-y665agnh 779 15 and and CC cord-023134-y665agnh 779 16 history history NN cord-023134-y665agnh 779 17 of of IN cord-023134-y665agnh 779 18 diarrhoea diarrhoea NN cord-023134-y665agnh 779 19 . . . cord-023134-y665agnh 780 1 Weak weak JJ cord-023134-y665agnh 780 2 or or CC cord-023134-y665agnh 780 3 borderline borderline JJ cord-023134-y665agnh 780 4 positive positive JJ cord-023134-y665agnh 780 5 results result NNS cord-023134-y665agnh 780 6 and and CC cord-023134-y665agnh 780 7 those those DT cord-023134-y665agnh 780 8 from from IN cord-023134-y665agnh 780 9 pooled pool VBN cord-023134-y665agnh 780 10 faecal faecal JJ cord-023134-y665agnh 780 11 samples sample NNS cord-023134-y665agnh 780 12 were be VBD cord-023134-y665agnh 780 13 excluded exclude VBN cord-023134-y665agnh 780 14 . . . cord-023134-y665agnh 781 1 Associations association NNS cord-023134-y665agnh 781 2 of of IN cord-023134-y665agnh 781 3 the the DT cord-023134-y665agnh 781 4 carriage carriage NN cord-023134-y665agnh 781 5 of of IN cord-023134-y665agnh 781 6 pairs pair NNS cord-023134-y665agnh 781 7 of of IN cord-023134-y665agnh 781 8 pathogens pathogen NNS cord-023134-y665agnh 781 9 were be VBD cord-023134-y665agnh 781 10 evaluated evaluate VBN cord-023134-y665agnh 781 11 with with IN cord-023134-y665agnh 781 12 a a DT cord-023134-y665agnh 781 13 Chi Chi NNP cord-023134-y665agnh 781 14 - - HYPH cord-023134-y665agnh 781 15 squared squared JJ cord-023134-y665agnh 781 16 test test NN cord-023134-y665agnh 781 17 , , , cord-023134-y665agnh 781 18 statistical statistical JJ cord-023134-y665agnh 781 19 significance significance NN cord-023134-y665agnh 781 20 set set VBN cord-023134-y665agnh 781 21 at at IN cord-023134-y665agnh 781 22 p p NN cord-023134-y665agnh 781 23 < < XX cord-023134-y665agnh 781 24 0.05.Results 0.05.results CD cord-023134-y665agnh 781 25 of of IN cord-023134-y665agnh 781 26 1882 1882 CD cord-023134-y665agnh 781 27 PCR PCR NNP cord-023134-y665agnh 781 28 panels panel NNS cord-023134-y665agnh 781 29 were be VBD cord-023134-y665agnh 781 30 evaluated evaluate VBN cord-023134-y665agnh 781 31 . . . cord-023134-y665agnh 782 1 The the DT cord-023134-y665agnh 782 2 prevalence prevalence NN cord-023134-y665agnh 782 3 of of IN cord-023134-y665agnh 782 4 faecal faecal JJ cord-023134-y665agnh 782 5 pathogens pathogen NNS cord-023134-y665agnh 782 6 was be VBD cord-023134-y665agnh 782 7 17.8 17.8 CD cord-023134-y665agnh 782 8 % % NN cord-023134-y665agnh 782 9 ( ( -LRB- cord-023134-y665agnh 782 10 Tritrichomonas Tritrichomonas NNP cord-023134-y665agnh 782 11 foetus foetus NN cord-023134-y665agnh 782 12 ) ) -RRB- cord-023134-y665agnh 782 13 , , , cord-023134-y665agnh 782 14 19.3 19.3 CD cord-023134-y665agnh 782 15 % % NN cord-023134-y665agnh 782 16 ( ( -LRB- cord-023134-y665agnh 782 17 Giardia Giardia NNP cord-023134-y665agnh 782 18 ) ) -RRB- cord-023134-y665agnh 782 19 , , , cord-023134-y665agnh 782 20 24.8 24.8 CD cord-023134-y665agnh 782 21 % % NN cord-023134-y665agnh 782 22 ( ( -LRB- cord-023134-y665agnh 782 23 Cryptosporidium Cryptosporidium NNP cord-023134-y665agnh 782 24 ) ) -RRB- cord-023134-y665agnh 782 25 , , , cord-023134-y665agnh 782 26 0.8 0.8 CD cord-023134-y665agnh 782 27 % % NN cord-023134-y665agnh 782 28 ( ( -LRB- cord-023134-y665agnh 782 29 Toxoplasma Toxoplasma NNP cord-023134-y665agnh 782 30 gondii gondii NNP cord-023134-y665agnh 782 31 ) ) -RRB- cord-023134-y665agnh 782 32 , , , cord-023134-y665agnh 782 33 0.5 0.5 CD cord-023134-y665agnh 782 34 % % NN cord-023134-y665agnh 782 35 ( ( -LRB- cord-023134-y665agnh 782 36 Salmonella Salmonella NNP cord-023134-y665agnh 782 37 ) ) -RRB- cord-023134-y665agnh 782 38 , , , cord-023134-y665agnh 782 39 54.7 54.7 CD cord-023134-y665agnh 782 40 % % NN cord-023134-y665agnh 782 41 ( ( -LRB- cord-023134-y665agnh 782 42 Clostridium clostridium NN cord-023134-y665agnh 782 43 perfringens perfringen NNS cord-023134-y665agnh 782 44 ) ) -RRB- cord-023134-y665agnh 782 45 , , , cord-023134-y665agnh 782 46 57.1 57.1 CD cord-023134-y665agnh 782 47 % % NN cord-023134-y665agnh 782 48 ( ( -LRB- cord-023134-y665agnh 782 49 feline feline JJ cord-023134-y665agnh 782 50 coronavirus coronavirus NN cord-023134-y665agnh 782 51 ) ) -RRB- cord-023134-y665agnh 782 52 , , , cord-023134-y665agnh 782 53 and and CC cord-023134-y665agnh 782 54 22.6 22.6 CD cord-023134-y665agnh 782 55 % % NN cord-023134-y665agnh 782 56 ( ( -LRB- cord-023134-y665agnh 782 57 feline feline JJ cord-023134-y665agnh 782 58 panleukopenia panleukopenia FW cord-023134-y665agnh 782 59 virus).Salmonella virus).salmonella NN cord-023134-y665agnh 782 60 was be VBD cord-023134-y665agnh 782 61 the the DT cord-023134-y665agnh 782 62 only only JJ cord-023134-y665agnh 782 63 faecal faecal JJ cord-023134-y665agnh 782 64 pathogen pathogen NN cord-023134-y665agnh 782 65 significantly significantly RB cord-023134-y665agnh 782 66 associated associate VBN cord-023134-y665agnh 782 67 with with IN cord-023134-y665agnh 782 68 a a DT cord-023134-y665agnh 782 69 history history NN cord-023134-y665agnh 782 70 of of IN cord-023134-y665agnh 782 71 diarrhoea diarrhoea NN cord-023134-y665agnh 782 72 . . . cord-023134-y665agnh 783 1 Faecal Faecal NNP cord-023134-y665agnh 783 2 samples sample NNS cord-023134-y665agnh 783 3 from from IN cord-023134-y665agnh 783 4 pedigree pedigree JJ cord-023134-y665agnh 783 5 cats cat NNS cord-023134-y665agnh 783 6 were be VBD cord-023134-y665agnh 783 7 significantly significantly RB cord-023134-y665agnh 783 8 more more RBR cord-023134-y665agnh 783 9 likely likely JJ cord-023134-y665agnh 783 10 than than IN cord-023134-y665agnh 783 11 DSH DSH NNP cord-023134-y665agnh 783 12 to to TO cord-023134-y665agnh 783 13 be be VB cord-023134-y665agnh 783 14 positive positive JJ cord-023134-y665agnh 783 15 for for IN cord-023134-y665agnh 783 16 Tritrichomonas Tritrichomonas NNP cord-023134-y665agnh 783 17 foetus foetus NN cord-023134-y665agnh 783 18 , , , cord-023134-y665agnh 783 19 Giardia Giardia NNP cord-023134-y665agnh 783 20 , , , cord-023134-y665agnh 783 21 Clostridium clostridium NN cord-023134-y665agnh 783 22 perfringens perfringens NN cord-023134-y665agnh 783 23 and and CC cord-023134-y665agnh 783 24 feline feline JJ cord-023134-y665agnh 783 25 coronavirus coronavirus NN cord-023134-y665agnh 783 26 . . . cord-023134-y665agnh 784 1 Significant significant JJ cord-023134-y665agnh 784 2 co co NN cord-023134-y665agnh 784 3 - - NN cord-023134-y665agnh 784 4 carriage carriage NN cord-023134-y665agnh 784 5 was be VBD cord-023134-y665agnh 784 6 identified identify VBN cord-023134-y665agnh 784 7 for for IN cord-023134-y665agnh 784 8 feline feline JJ cord-023134-y665agnh 784 9 coronavirus coronavirus NN cord-023134-y665agnh 784 10 with with IN cord-023134-y665agnh 784 11 all all DT cord-023134-y665agnh 784 12 other other JJ cord-023134-y665agnh 784 13 pathogens pathogen NNS cord-023134-y665agnh 784 14 except except IN cord-023134-y665agnh 784 15 Salmonella Salmonella NNP cord-023134-y665agnh 784 16 . . . cord-023134-y665agnh 785 1 There there EX cord-023134-y665agnh 785 2 was be VBD cord-023134-y665agnh 785 3 significant significant JJ cord-023134-y665agnh 785 4 co co NN cord-023134-y665agnh 785 5 - - NN cord-023134-y665agnh 785 6 carriage carriage NN cord-023134-y665agnh 785 7 of of IN cord-023134-y665agnh 785 8 Tritrichomonas Tritrichomonas NNP cord-023134-y665agnh 785 9 foetus foetus NN cord-023134-y665agnh 785 10 with with IN cord-023134-y665agnh 785 11 Clostridium clostridium NN cord-023134-y665agnh 785 12 perfringens perfringen NNS cord-023134-y665agnh 785 13 and and CC cord-023134-y665agnh 785 14 Giardia Giardia NNP cord-023134-y665agnh 785 15 , , , cord-023134-y665agnh 785 16 and and CC cord-023134-y665agnh 785 17 also also RB cord-023134-y665agnh 785 18 for for IN cord-023134-y665agnh 785 19 Giardia Giardia NNP cord-023134-y665agnh 785 20 with with IN cord-023134-y665agnh 785 21 panleukopenia panleukopenia NNP cord-023134-y665agnh 785 22 virus virus NN cord-023134-y665agnh 785 23 , , , cord-023134-y665agnh 785 24 Cryptosporidium cryptosporidium NN cord-023134-y665agnh 785 25 , , , cord-023134-y665agnh 785 26 and and CC cord-023134-y665agnh 785 27 Clostridium clostridium NN cord-023134-y665agnh 785 28 perfringens perfringen NNS cord-023134-y665agnh 785 29 . . . cord-023134-y665agnh 786 1 Finally finally RB cord-023134-y665agnh 786 2 , , , cord-023134-y665agnh 786 3 there there EX cord-023134-y665agnh 786 4 was be VBD cord-023134-y665agnh 786 5 significant significant JJ cord-023134-y665agnh 786 6 co co NN cord-023134-y665agnh 786 7 - - NN cord-023134-y665agnh 786 8 carriage carriage NN cord-023134-y665agnh 786 9 of of IN cord-023134-y665agnh 786 10 Cryptosporidium cryptosporidium NN cord-023134-y665agnh 786 11 with with IN cord-023134-y665agnh 786 12 Clostridium clostridium NN cord-023134-y665agnh 786 13 perfringens perfringen NNS cord-023134-y665agnh 786 14 , , , cord-023134-y665agnh 786 15 panleukopenia panleukopenia NNP cord-023134-y665agnh 786 16 virus virus NN cord-023134-y665agnh 786 17 with with IN cord-023134-y665agnh 786 18 Cryptosporidium cryptosporidium NN cord-023134-y665agnh 786 19 , , , cord-023134-y665agnh 786 20 and and CC cord-023134-y665agnh 786 21 Toxoplasma toxoplasma NN cord-023134-y665agnh 786 22 gondii gondii NN cord-023134-y665agnh 786 23 with with IN cord-023134-y665agnh 786 24 Salmonella Salmonella NNP cord-023134-y665agnh 786 25 . . . cord-023134-y665agnh 787 1 In in IN cord-023134-y665agnh 787 2 conclusion conclusion NN cord-023134-y665agnh 787 3 there there EX cord-023134-y665agnh 787 4 was be VBD cord-023134-y665agnh 787 5 a a DT cord-023134-y665agnh 787 6 moderate moderate JJ cord-023134-y665agnh 787 7 to to IN cord-023134-y665agnh 787 8 high high JJ cord-023134-y665agnh 787 9 prevalence prevalence NN cord-023134-y665agnh 787 10 of of IN cord-023134-y665agnh 787 11 all all DT cord-023134-y665agnh 787 12 feline feline JJ cord-023134-y665agnh 787 13 faecal faecal JJ cord-023134-y665agnh 787 14 pathogens pathogen NNS cord-023134-y665agnh 787 15 tested test VBN cord-023134-y665agnh 787 16 except except IN cord-023134-y665agnh 787 17 Toxoplasma toxoplasma NN cord-023134-y665agnh 787 18 gondii gondii NN cord-023134-y665agnh 787 19 and and CC cord-023134-y665agnh 787 20 Salmonella Salmonella NNP cord-023134-y665agnh 787 21 . . . cord-023134-y665agnh 788 1 Positive positive JJ cord-023134-y665agnh 788 2 PCR PCR NNP cord-023134-y665agnh 788 3 results result NNS cord-023134-y665agnh 788 4 were be VBD cord-023134-y665agnh 788 5 more more RBR cord-023134-y665agnh 788 6 likely likely JJ cord-023134-y665agnh 788 7 in in IN cord-023134-y665agnh 788 8 pedigree pedigree JJ cord-023134-y665agnh 788 9 cats cat NNS cord-023134-y665agnh 788 10 , , , cord-023134-y665agnh 788 11 and and CC cord-023134-y665agnh 788 12 Salmonella Salmonella NNP cord-023134-y665agnh 788 13 was be VBD cord-023134-y665agnh 788 14 associated associate VBN cord-023134-y665agnh 788 15 with with IN cord-023134-y665agnh 788 16 a a DT cord-023134-y665agnh 788 17 history history NN cord-023134-y665agnh 788 18 of of IN cord-023134-y665agnh 788 19 diarrhoea diarrhoea NN cord-023134-y665agnh 788 20 . . . cord-023134-y665agnh 789 1 Significant significant JJ cord-023134-y665agnh 789 2 co co NN cord-023134-y665agnh 789 3 - - NN cord-023134-y665agnh 789 4 carriage carriage NN cord-023134-y665agnh 789 5 of of IN cord-023134-y665agnh 789 6 faecal faecal JJ cord-023134-y665agnh 789 7 pathogens pathogen NNS cord-023134-y665agnh 789 8 was be VBD cord-023134-y665agnh 789 9 common common JJ cord-023134-y665agnh 789 10 , , , cord-023134-y665agnh 789 11 possibly possibly RB cord-023134-y665agnh 789 12 reflecting reflect VBG cord-023134-y665agnh 789 13 common common JJ cord-023134-y665agnh 789 14 environmental environmental JJ cord-023134-y665agnh 789 15 risk risk NN cord-023134-y665agnh 789 16 factors factor NNS cord-023134-y665agnh 789 17 , , , cord-023134-y665agnh 789 18 a a DT cord-023134-y665agnh 789 19 shared share VBN cord-023134-y665agnh 789 20 pathogenesis pathogenesis NN cord-023134-y665agnh 789 21 , , , cord-023134-y665agnh 789 22 or or CC cord-023134-y665agnh 789 23 a a DT cord-023134-y665agnh 789 24 symbiotic symbiotic JJ cord-023134-y665agnh 789 25 relationship relationship NN cord-023134-y665agnh 789 26 . . . cord-023134-y665agnh 790 1 Mycoplasma mycoplasma NN cord-023134-y665agnh 790 2 spp spp NNS cord-023134-y665agnh 790 3 have have VBP cord-023134-y665agnh 790 4 been be VBN cord-023134-y665agnh 790 5 identified identify VBN cord-023134-y665agnh 790 6 as as IN cord-023134-y665agnh 790 7 causative causative JJ cord-023134-y665agnh 790 8 pathogen pathogen NN cord-023134-y665agnh 790 9 in in IN cord-023134-y665agnh 790 10 feline feline JJ cord-023134-y665agnh 790 11 lower low JJR cord-023134-y665agnh 790 12 airway airway NN cord-023134-y665agnh 790 13 disease disease NN cord-023134-y665agnh 790 14 and and CC cord-023134-y665agnh 790 15 are be VBP cord-023134-y665agnh 790 16 not not RB cord-023134-y665agnh 790 17 thought think VBN cord-023134-y665agnh 790 18 to to TO cord-023134-y665agnh 790 19 colonize colonize VB cord-023134-y665agnh 790 20 the the DT cord-023134-y665agnh 790 21 lower low JJR cord-023134-y665agnh 790 22 airways airway NNS cord-023134-y665agnh 790 23 of of IN cord-023134-y665agnh 790 24 clinically clinically RB cord-023134-y665agnh 790 25 healthy healthy JJ cord-023134-y665agnh 790 26 cats cat NNS cord-023134-y665agnh 790 27 . . . cord-023134-y665agnh 791 1 To to TO cord-023134-y665agnh 791 2 challenge challenge VB cord-023134-y665agnh 791 3 this this DT cord-023134-y665agnh 791 4 hypothesis hypothesis NN cord-023134-y665agnh 791 5 , , , cord-023134-y665agnh 791 6 30 30 CD cord-023134-y665agnh 791 7 domestic domestic JJ cord-023134-y665agnh 791 8 shorthair shorthair JJ cord-023134-y665agnh 791 9 cats cat NNS cord-023134-y665agnh 791 10 aged age VBN cord-023134-y665agnh 791 11 1 1 CD cord-023134-y665agnh 791 12 - - SYM cord-023134-y665agnh 791 13 10 10 CD cord-023134-y665agnh 791 14 years year NNS cord-023134-y665agnh 791 15 ( ( -LRB- cord-023134-y665agnh 791 16 median median NN cord-023134-y665agnh 791 17 , , , cord-023134-y665agnh 791 18 4.5 4.5 CD cord-023134-y665agnh 791 19 years year NNS cord-023134-y665agnh 791 20 ) ) -RRB- cord-023134-y665agnh 791 21 , , , cord-023134-y665agnh 791 22 without without IN cord-023134-y665agnh 791 23 signs sign NNS cord-023134-y665agnh 791 24 of of IN cord-023134-y665agnh 791 25 respiratory respiratory JJ cord-023134-y665agnh 791 26 disease disease NN cord-023134-y665agnh 791 27 , , , cord-023134-y665agnh 791 28 housed house VBN cord-023134-y665agnh 791 29 in in IN cord-023134-y665agnh 791 30 a a DT cord-023134-y665agnh 791 31 shelter shelter NN cord-023134-y665agnh 791 32 , , , cord-023134-y665agnh 791 33 underwent undergo VBD cord-023134-y665agnh 791 34 transoral transoral NNP cord-023134-y665agnh 791 35 lower low JJR cord-023134-y665agnh 791 36 airway airway NN cord-023134-y665agnh 791 37 washing washing NN cord-023134-y665agnh 791 38 with with IN cord-023134-y665agnh 791 39 sterile sterile JJ cord-023134-y665agnh 791 40 saline saline NN cord-023134-y665agnh 791 41 under under IN cord-023134-y665agnh 791 42 general general JJ cord-023134-y665agnh 791 43 anaesthesia anaesthesia NN cord-023134-y665agnh 791 44 . . . cord-023134-y665agnh 792 1 Retrieved Retrieved NNP cord-023134-y665agnh 792 2 bronchalveolar bronchalveolar NNP cord-023134-y665agnh 792 3 lavage lavage NN cord-023134-y665agnh 792 4 fluid fluid NN cord-023134-y665agnh 792 5 ( ( -LRB- cord-023134-y665agnh 792 6 BALF BALF NNP cord-023134-y665agnh 792 7 ) ) -RRB- cord-023134-y665agnh 792 8 was be VBD cord-023134-y665agnh 792 9 subjected subject VBN cord-023134-y665agnh 792 10 to to IN cord-023134-y665agnh 792 11 microbiological microbiological JJ cord-023134-y665agnh 792 12 and and CC cord-023134-y665agnh 792 13 cytological cytological JJ cord-023134-y665agnh 792 14 analysis analysis NN cord-023134-y665agnh 792 15 . . . cord-023134-y665agnh 793 1 During during IN cord-023134-y665agnh 793 2 preanaesthetic preanaesthetic JJ cord-023134-y665agnh 793 3 clinical clinical JJ cord-023134-y665agnh 793 4 examination examination NN cord-023134-y665agnh 793 5 , , , cord-023134-y665agnh 793 6 only only RB cord-023134-y665agnh 793 7 minor minor JJ cord-023134-y665agnh 793 8 alterations alteration NNS cord-023134-y665agnh 793 9 were be VBD cord-023134-y665agnh 793 10 discovered discover VBN cord-023134-y665agnh 793 11 : : : cord-023134-y665agnh 793 12 tartar tartar NN cord-023134-y665agnh 793 13 in in IN cord-023134-y665agnh 793 14 7 7 CD cord-023134-y665agnh 793 15 , , , cord-023134-y665agnh 793 16 conjunctivitis conjunctivitis NN cord-023134-y665agnh 793 17 in in IN cord-023134-y665agnh 793 18 4 4 CD cord-023134-y665agnh 793 19 , , , cord-023134-y665agnh 793 20 flea flea NN cord-023134-y665agnh 793 21 infestation infestation NN cord-023134-y665agnh 793 22 in in IN cord-023134-y665agnh 793 23 3 3 CD cord-023134-y665agnh 793 24 and and CC cord-023134-y665agnh 793 25 dirty dirty JJ cord-023134-y665agnh 793 26 auditory auditory JJ cord-023134-y665agnh 793 27 canals canal NNS cord-023134-y665agnh 793 28 in in IN cord-023134-y665agnh 793 29 3 3 CD cord-023134-y665agnh 793 30 cats cat NNS cord-023134-y665agnh 793 31 . . . cord-023134-y665agnh 794 1 One one CD cord-023134-y665agnh 794 2 animal animal NN cord-023134-y665agnh 794 3 each each DT cord-023134-y665agnh 794 4 showed show VBD cord-023134-y665agnh 794 5 dandruff dandruff NN cord-023134-y665agnh 794 6 , , , cord-023134-y665agnh 794 7 corneal corneal JJ cord-023134-y665agnh 794 8 ulceration ulceration NN cord-023134-y665agnh 794 9 and and CC cord-023134-y665agnh 794 10 a a DT cord-023134-y665agnh 794 11 heart heart NN cord-023134-y665agnh 794 12 murmur murmur VBP cord-023134-y665agnh 794 13 2/6.BALF 2/6.balf CD cord-023134-y665agnh 794 14 - - HYPH cord-023134-y665agnh 794 15 cultures culture NNS cord-023134-y665agnh 794 16 of of IN cord-023134-y665agnh 794 17 26 26 CD cord-023134-y665agnh 794 18 animals animal NNS cord-023134-y665agnh 794 19 ( ( -LRB- cord-023134-y665agnh 794 20 86.7 86.7 CD cord-023134-y665agnh 794 21 % % NN cord-023134-y665agnh 794 22 ) ) -RRB- cord-023134-y665agnh 794 23 were be VBD cord-023134-y665agnh 794 24 positive positive JJ cord-023134-y665agnh 794 25 for for IN cord-023134-y665agnh 794 26 Mycoplasma mycoplasma NN cord-023134-y665agnh 794 27 spp spp NNS cord-023134-y665agnh 794 28 . . . cord-023134-y665agnh 795 1 66.7 66.7 CD cord-023134-y665agnh 795 2 % % NN cord-023134-y665agnh 795 3 of of IN cord-023134-y665agnh 795 4 examined examine VBN cord-023134-y665agnh 795 5 cats cat NNS cord-023134-y665agnh 795 6 had have VBD cord-023134-y665agnh 795 7 Mycoplasma Mycoplasma VBN cord-023134-y665agnh 795 8 felis felis NN cord-023134-y665agnh 795 9 in in IN cord-023134-y665agnh 795 10 their -PRON- PRP$ cord-023134-y665agnh 795 11 BALF BALF NNP cord-023134-y665agnh 795 12 ( ( -LRB- cord-023134-y665agnh 795 13 light light JJ cord-023134-y665agnh 795 14 growth growth NN cord-023134-y665agnh 795 15 in in IN cord-023134-y665agnh 795 16 11 11 CD cord-023134-y665agnh 795 17 , , , cord-023134-y665agnh 795 18 moderate moderate JJ cord-023134-y665agnh 795 19 growth growth NN cord-023134-y665agnh 795 20 in in IN cord-023134-y665agnh 795 21 4 4 CD cord-023134-y665agnh 795 22 and and CC cord-023134-y665agnh 795 23 heavy heavy JJ cord-023134-y665agnh 795 24 growth growth NN cord-023134-y665agnh 795 25 in in IN cord-023134-y665agnh 795 26 5 5 CD cord-023134-y665agnh 795 27 animals animal NNS cord-023134-y665agnh 795 28 ) ) -RRB- cord-023134-y665agnh 795 29 , , , cord-023134-y665agnh 795 30 50 50 CD cord-023134-y665agnh 795 31 % % NN cord-023134-y665agnh 795 32 Ureaplasma Ureaplasma NNP cord-023134-y665agnh 795 33 felinum felinum NNP cord-023134-y665agnh 795 34 / / SYM cord-023134-y665agnh 795 35 cati cati NNP cord-023134-y665agnh 795 36 ( ( -LRB- cord-023134-y665agnh 795 37 light light JJ cord-023134-y665agnh 795 38 growth growth NN cord-023134-y665agnh 795 39 in in IN cord-023134-y665agnh 795 40 8 8 CD cord-023134-y665agnh 795 41 , , , cord-023134-y665agnh 795 42 moderate moderate JJ cord-023134-y665agnh 795 43 growth growth NN cord-023134-y665agnh 795 44 in in IN cord-023134-y665agnh 795 45 7 7 CD cord-023134-y665agnh 795 46 cases case NNS cord-023134-y665agnh 795 47 ) ) -RRB- cord-023134-y665agnh 795 48 , , , cord-023134-y665agnh 795 49 23.3 23.3 CD cord-023134-y665agnh 795 50 % % NN cord-023134-y665agnh 795 51 Mycoplasma Mycoplasma NNP cord-023134-y665agnh 795 52 gateae gateae NNP cord-023134-y665agnh 795 53 ( ( -LRB- cord-023134-y665agnh 795 54 light light JJ cord-023134-y665agnh 795 55 growth growth NN cord-023134-y665agnh 795 56 in in IN cord-023134-y665agnh 795 57 4 4 CD cord-023134-y665agnh 795 58 , , , cord-023134-y665agnh 795 59 moderate moderate JJ cord-023134-y665agnh 795 60 growth growth NN cord-023134-y665agnh 795 61 in in IN cord-023134-y665agnh 795 62 2 2 CD cord-023134-y665agnh 795 63 and and CC cord-023134-y665agnh 795 64 heavy heavy JJ cord-023134-y665agnh 795 65 growth growth NN cord-023134-y665agnh 795 66 in in IN cord-023134-y665agnh 795 67 1 1 CD cord-023134-y665agnh 795 68 cat cat NN cord-023134-y665agnh 795 69 ) ) -RRB- cord-023134-y665agnh 795 70 and and CC cord-023134-y665agnh 795 71 3.3 3.3 CD cord-023134-y665agnh 795 72 % % NN cord-023134-y665agnh 795 73 Mycoplasma Mycoplasma NNP cord-023134-y665agnh 795 74 feliminutum feliminutum IN cord-023134-y665agnh 795 75 ( ( -LRB- cord-023134-y665agnh 795 76 light light JJ cord-023134-y665agnh 795 77 growth growth NN cord-023134-y665agnh 795 78 in in IN cord-023134-y665agnh 795 79 1 1 CD cord-023134-y665agnh 795 80 animal animal NN cord-023134-y665agnh 795 81 ) ) -RRB- cord-023134-y665agnh 795 82 . . . cord-023134-y665agnh 796 1 Using use VBG cord-023134-y665agnh 796 2 aerobic aerobic JJ cord-023134-y665agnh 796 3 bacterial bacterial JJ cord-023134-y665agnh 796 4 culture culture NN cord-023134-y665agnh 796 5 , , , cord-023134-y665agnh 796 6 Pasteurella Pasteurella NNP cord-023134-y665agnh 796 7 multocida multocida NNP cord-023134-y665agnh 796 8 ( ( -LRB- cord-023134-y665agnh 796 9 46.7 46.7 CD cord-023134-y665agnh 796 10 % % NN cord-023134-y665agnh 796 11 ) ) -RRB- cord-023134-y665agnh 796 12 , , , cord-023134-y665agnh 796 13 a a DT cord-023134-y665agnh 796 14 - - HYPH cord-023134-y665agnh 796 15 haemolytic haemolytic JJ cord-023134-y665agnh 796 16 Streptococci Streptococci NNP cord-023134-y665agnh 796 17 ( ( -LRB- cord-023134-y665agnh 796 18 33.3 33.3 CD cord-023134-y665agnh 796 19 % % NN cord-023134-y665agnh 796 20 ) ) -RRB- cord-023134-y665agnh 796 21 , , , cord-023134-y665agnh 796 22 haemolytic haemolytic JJ cord-023134-y665agnh 796 23 E. E. NNP cord-023134-y665agnh 796 24 coli coli NNS cord-023134-y665agnh 796 25 ( ( -LRB- cord-023134-y665agnh 796 26 3.3 3.3 CD cord-023134-y665agnh 796 27 % % NN cord-023134-y665agnh 796 28 ) ) -RRB- cord-023134-y665agnh 796 29 and and CC cord-023134-y665agnh 796 30 Acinetobacter Acinetobacter NNP cord-023134-y665agnh 796 31 Iwoffii Iwoffii NNP cord-023134-y665agnh 796 32 ( ( -LRB- cord-023134-y665agnh 796 33 3.3 3.3 CD cord-023134-y665agnh 796 34 % % NN cord-023134-y665agnh 796 35 ) ) -RRB- cord-023134-y665agnh 796 36 were be VBD cord-023134-y665agnh 796 37 detected detect VBN cord-023134-y665agnh 796 38 , , , cord-023134-y665agnh 796 39 with with IN cord-023134-y665agnh 796 40 only only RB cord-023134-y665agnh 796 41 7 7 CD cord-023134-y665agnh 796 42 samples sample NNS cord-023134-y665agnh 796 43 ( ( -LRB- cord-023134-y665agnh 796 44 23.3 23.3 CD cord-023134-y665agnh 796 45 % % NN cord-023134-y665agnh 796 46 ) ) -RRB- cord-023134-y665agnh 796 47 yielding yield VBG cord-023134-y665agnh 796 48 negative negative JJ cord-023134-y665agnh 796 49 results result NNS cord-023134-y665agnh 796 50 . . . cord-023134-y665agnh 797 1 Median median JJ cord-023134-y665agnh 797 2 BALF BALF NNP cord-023134-y665agnh 797 3 - - HYPH cord-023134-y665agnh 797 4 total total JJ cord-023134-y665agnh 797 5 nucleated nucleated JJ cord-023134-y665agnh 797 6 cell cell NN cord-023134-y665agnh 797 7 count count NN cord-023134-y665agnh 797 8 was be VBD cord-023134-y665agnh 797 9 550 550 CD cord-023134-y665agnh 797 10 / / SYM cord-023134-y665agnh 797 11 ll ll VB cord-023134-y665agnh 797 12 ( ( -LRB- cord-023134-y665agnh 797 13 range range VB cord-023134-y665agnh 797 14 , , , cord-023134-y665agnh 797 15 4 4 CD cord-023134-y665agnh 797 16 - - HYPH cord-023134-y665agnh 797 17 7790 7790 CD cord-023134-y665agnh 797 18 ) ) -RRB- cord-023134-y665agnh 797 19 with with IN cord-023134-y665agnh 797 20 a a DT cord-023134-y665agnh 797 21 median median JJ cord-023134-y665agnh 797 22 mononucleated mononucleated JJ cord-023134-y665agnh 797 23 cell cell NN cord-023134-y665agnh 797 24 percentage percentage NN cord-023134-y665agnh 797 25 of of IN cord-023134-y665agnh 797 26 73 73 CD cord-023134-y665agnh 797 27 % % NN cord-023134-y665agnh 797 28 , , , cord-023134-y665agnh 797 29 a a DT cord-023134-y665agnh 797 30 median median JJ cord-023134-y665agnh 797 31 neutrophil neutrophil NN cord-023134-y665agnh 797 32 fraction fraction NN cord-023134-y665agnh 797 33 of of IN cord-023134-y665agnh 797 34 15.5 15.5 CD cord-023134-y665agnh 797 35 % % NN cord-023134-y665agnh 797 36 and and CC cord-023134-y665agnh 797 37 a a DT cord-023134-y665agnh 797 38 median median JJ cord-023134-y665agnh 797 39 eosinophil eosinophil JJ cord-023134-y665agnh 797 40 proportion proportion NN cord-023134-y665agnh 797 41 of of IN cord-023134-y665agnh 797 42 1.5 1.5 CD cord-023134-y665agnh 797 43 % % NN cord-023134-y665agnh 797 44 . . . cord-023134-y665agnh 798 1 Only only RB cord-023134-y665agnh 798 2 2 2 CD cord-023134-y665agnh 798 3 samples sample NNS cord-023134-y665agnh 798 4 were be VBD cord-023134-y665agnh 798 5 neutrophil neutrophil NN cord-023134-y665agnh 798 6 - - HYPH cord-023134-y665agnh 798 7 dominated dominate VBN cord-023134-y665agnh 798 8 ( ( -LRB- cord-023134-y665agnh 798 9 92.5 92.5 CD cord-023134-y665agnh 798 10 and and CC cord-023134-y665agnh 798 11 97.5 97.5 CD cord-023134-y665agnh 798 12 % % NN cord-023134-y665agnh 798 13 ) ) -RRB- cord-023134-y665agnh 798 14 , , , cord-023134-y665agnh 798 15 indicating indicate VBG cord-023134-y665agnh 798 16 purulent purulent JJ cord-023134-y665agnh 798 17 inflammation inflammation NN cord-023134-y665agnh 798 18 . . . cord-023134-y665agnh 799 1 Both both DT cord-023134-y665agnh 799 2 specimens specimen NNS cord-023134-y665agnh 799 3 were be VBD cord-023134-y665agnh 799 4 positive positive JJ cord-023134-y665agnh 799 5 for for IN cord-023134-y665agnh 799 6 Mycoplasma Mycoplasma NNP cord-023134-y665agnh 799 7 felis felis NN cord-023134-y665agnh 799 8 ( ( -LRB- cord-023134-y665agnh 799 9 1 1 CD cord-023134-y665agnh 799 10 light light JJ cord-023134-y665agnh 799 11 growth growth NN cord-023134-y665agnh 799 12 , , , cord-023134-y665agnh 799 13 1 1 CD cord-023134-y665agnh 799 14 heavy heavy JJ cord-023134-y665agnh 799 15 growth growth NN cord-023134-y665agnh 799 16 ) ) -RRB- cord-023134-y665agnh 799 17 , , , cord-023134-y665agnh 799 18 and and CC cord-023134-y665agnh 799 19 one one CD cord-023134-y665agnh 799 20 showed show VBD cord-023134-y665agnh 799 21 moderate moderate JJ cord-023134-y665agnh 799 22 growth growth NN cord-023134-y665agnh 799 23 of of IN cord-023134-y665agnh 799 24 Pasteurella Pasteurella NNP cord-023134-y665agnh 799 25 multocida multocida NNP cord-023134-y665agnh 799 26 . . . cord-023134-y665agnh 800 1 Like like IN cord-023134-y665agnh 800 2 all all DT cord-023134-y665agnh 800 3 of of IN cord-023134-y665agnh 800 4 the the DT cord-023134-y665agnh 800 5 animals animal NNS cord-023134-y665agnh 800 6 included include VBN cord-023134-y665agnh 800 7 in in IN cord-023134-y665agnh 800 8 this this DT cord-023134-y665agnh 800 9 study study NN cord-023134-y665agnh 800 10 , , , cord-023134-y665agnh 800 11 the the DT cord-023134-y665agnh 800 12 corresponding correspond VBG cord-023134-y665agnh 800 13 cats cat NNS cord-023134-y665agnh 800 14 remained remain VBD cord-023134-y665agnh 800 15 clinically clinically RB cord-023134-y665agnh 800 16 healthy healthy JJ cord-023134-y665agnh 800 17 during during IN cord-023134-y665agnh 800 18 a a DT cord-023134-y665agnh 800 19 2-week 2-week CD cord-023134-y665agnh 800 20 followup followup JJ cord-023134-y665agnh 800 21 period period NN cord-023134-y665agnh 800 22 . . . cord-023134-y665agnh 801 1 BALF BALF NNP cord-023134-y665agnh 801 2 - - HYPH cord-023134-y665agnh 801 3 samples sample NNS cord-023134-y665agnh 801 4 showed show VBD cord-023134-y665agnh 801 5 neither neither CC cord-023134-y665agnh 801 6 cytological cytological JJ cord-023134-y665agnh 801 7 nor nor CC cord-023134-y665agnh 801 8 microbiological microbiological JJ cord-023134-y665agnh 801 9 signs sign NNS cord-023134-y665agnh 801 10 indicative indicative JJ cord-023134-y665agnh 801 11 of of IN cord-023134-y665agnh 801 12 upper upper JJ cord-023134-y665agnh 801 13 airway airway NN cord-023134-y665agnh 801 14 contamination contamination NN cord-023134-y665agnh 801 15 . . . cord-023134-y665agnh 802 1 In in IN cord-023134-y665agnh 802 2 contrast contrast NN cord-023134-y665agnh 802 3 to to IN cord-023134-y665agnh 802 4 earlier early JJR cord-023134-y665agnh 802 5 studies study NNS cord-023134-y665agnh 802 6 , , , cord-023134-y665agnh 802 7 we -PRON- PRP cord-023134-y665agnh 802 8 conclude conclude VBP cord-023134-y665agnh 802 9 that that IN cord-023134-y665agnh 802 10 -at -at : cord-023134-y665agnh 802 11 least least JJS cord-023134-y665agnh 802 12 in in IN cord-023134-y665agnh 802 13 cats cat NNS cord-023134-y665agnh 802 14 housed house VBN cord-023134-y665agnh 802 15 in in IN cord-023134-y665agnh 802 16 shel shel NNP cord-023134-y665agnh 802 17 - - HYPH cord-023134-y665agnh 802 18 ters ter NNS cord-023134-y665agnh 802 19 and and CC cord-023134-y665agnh 802 20 subjected subject VBN cord-023134-y665agnh 802 21 to to IN cord-023134-y665agnh 802 22 high high JJ cord-023134-y665agnh 802 23 infection infection NN cord-023134-y665agnh 802 24 pressure pressure NN cord-023134-y665agnh 802 25 -in -in IN cord-023134-y665agnh 802 26 addition addition NN cord-023134-y665agnh 802 27 to to IN cord-023134-y665agnh 802 28 bacteria bacteria NNS cord-023134-y665agnh 802 29 like like IN cord-023134-y665agnh 802 30 Pasteurella Pasteurella NNP cord-023134-y665agnh 802 31 spp spp NNS cord-023134-y665agnh 802 32 , , , cord-023134-y665agnh 802 33 Streptococcus streptococcus NN cord-023134-y665agnh 802 34 spp spp NNS cord-023134-y665agnh 802 35 and and CC cord-023134-y665agnh 802 36 E. E. NNP cord-023134-y665agnh 802 37 coli coli NNS cord-023134-y665agnh 802 38 , , , cord-023134-y665agnh 802 39 Mycoplasma mycoplasma NN cord-023134-y665agnh 802 40 spp spp NNS cord-023134-y665agnh 802 41 can can MD cord-023134-y665agnh 802 42 occur occur VB cord-023134-y665agnh 802 43 in in IN cord-023134-y665agnh 802 44 the the DT cord-023134-y665agnh 802 45 feline feline JJ cord-023134-y665agnh 802 46 lower low JJR cord-023134-y665agnh 802 47 airways airway NNS cord-023134-y665agnh 802 48 without without IN cord-023134-y665agnh 802 49 causing cause VBG cord-023134-y665agnh 802 50 respiratory respiratory JJ cord-023134-y665agnh 802 51 signs sign NNS cord-023134-y665agnh 802 52 . . . cord-023134-y665agnh 803 1 Inflammasomes inflammasome NNS cord-023134-y665agnh 803 2 are be VBP cord-023134-y665agnh 803 3 intracellular intracellular JJ cord-023134-y665agnh 803 4 multi multi JJ cord-023134-y665agnh 803 5 - - JJ cord-023134-y665agnh 803 6 protein protein JJ cord-023134-y665agnh 803 7 complexes complex NNS cord-023134-y665agnh 803 8 that that WDT cord-023134-y665agnh 803 9 coordinate coordinate VBP cord-023134-y665agnh 803 10 the the DT cord-023134-y665agnh 803 11 maturation maturation NN cord-023134-y665agnh 803 12 of of IN cord-023134-y665agnh 803 13 Interleukin Interleukin NNP cord-023134-y665agnh 803 14 ( ( -LRB- cord-023134-y665agnh 803 15 IL)-1b IL)-1b NNPS cord-023134-y665agnh 803 16 and and CC cord-023134-y665agnh 803 17 IL-18 IL-18 NNP cord-023134-y665agnh 803 18 in in IN cord-023134-y665agnh 803 19 response response NN cord-023134-y665agnh 803 20 to to IN cord-023134-y665agnh 803 21 pathogens pathogen NNS cord-023134-y665agnh 803 22 and and CC cord-023134-y665agnh 803 23 metabolic metabolic JJ cord-023134-y665agnh 803 24 danger danger NN cord-023134-y665agnh 803 25 signals signal NNS cord-023134-y665agnh 803 26 . . . cord-023134-y665agnh 804 1 Both both DT cord-023134-y665agnh 804 2 cytokines cytokine NNS cord-023134-y665agnh 804 3 are be VBP cord-023134-y665agnh 804 4 vital vital JJ cord-023134-y665agnh 804 5 for for IN cord-023134-y665agnh 804 6 the the DT cord-023134-y665agnh 804 7 maintenance maintenance NN cord-023134-y665agnh 804 8 of of IN cord-023134-y665agnh 804 9 the the DT cord-023134-y665agnh 804 10 intestinal intestinal JJ cord-023134-y665agnh 804 11 homeostasis homeostasis NN cord-023134-y665agnh 804 12 and and CC cord-023134-y665agnh 804 13 have have VBP cord-023134-y665agnh 804 14 been be VBN cord-023134-y665agnh 804 15 linked link VBN cord-023134-y665agnh 804 16 to to IN cord-023134-y665agnh 804 17 chronic chronic JJ cord-023134-y665agnh 804 18 intestinal intestinal JJ cord-023134-y665agnh 804 19 inflammation inflammation NN cord-023134-y665agnh 804 20 in in IN cord-023134-y665agnh 804 21 humans human NNS cord-023134-y665agnh 804 22 . . . cord-023134-y665agnh 805 1 Both both DT cord-023134-y665agnh 805 2 IL-1b IL-1b NNS cord-023134-y665agnh 805 3 and and CC cord-023134-y665agnh 805 4 IL-18 IL-18 NNP cord-023134-y665agnh 805 5 are be VBP cord-023134-y665agnh 805 6 produced produce VBN cord-023134-y665agnh 805 7 as as IN cord-023134-y665agnh 805 8 inactive inactive JJ cord-023134-y665agnh 805 9 proforms proform NNS cord-023134-y665agnh 805 10 and and CC cord-023134-y665agnh 805 11 undergo undergo VB cord-023134-y665agnh 805 12 subsequent subsequent JJ cord-023134-y665agnh 805 13 maturation maturation NN cord-023134-y665agnh 805 14 through through IN cord-023134-y665agnh 805 15 cleavage cleavage NN cord-023134-y665agnh 805 16 into into IN cord-023134-y665agnh 805 17 their -PRON- PRP$ cord-023134-y665agnh 805 18 active active JJ cord-023134-y665agnh 805 19 forms form NNS cord-023134-y665agnh 805 20 by by IN cord-023134-y665agnh 805 21 caspase caspase NN cord-023134-y665agnh 805 22 ( ( -LRB- cord-023134-y665agnh 805 23 casp)-1 casp)-1 CD cord-023134-y665agnh 805 24 , , , cord-023134-y665agnh 805 25 which which WDT cord-023134-y665agnh 805 26 is be VBZ cord-023134-y665agnh 805 27 in in IN cord-023134-y665agnh 805 28 turn turn NN cord-023134-y665agnh 805 29 activated activate VBN cord-023134-y665agnh 805 30 by by IN cord-023134-y665agnh 805 31 the the DT cord-023134-y665agnh 805 32 inflammasome inflammasome NN cord-023134-y665agnh 805 33 complex complex NN cord-023134-y665agnh 805 34 . . . cord-023134-y665agnh 806 1 The the DT cord-023134-y665agnh 806 2 best well RBS cord-023134-y665agnh 806 3 characterized characterize VBN cord-023134-y665agnh 806 4 inflammasome inflammasome NN cord-023134-y665agnh 806 5 subtype subtype NN cord-023134-y665agnh 806 6 in in IN cord-023134-y665agnh 806 7 human human JJ cord-023134-y665agnh 806 8 inflammatory inflammatory JJ cord-023134-y665agnh 806 9 bowel bowel NN cord-023134-y665agnh 806 10 disease disease NN cord-023134-y665agnh 806 11 ( ( -LRB- cord-023134-y665agnh 806 12 IBD IBD NNP cord-023134-y665agnh 806 13 ) ) -RRB- cord-023134-y665agnh 806 14 is be VBZ cord-023134-y665agnh 806 15 NLRP3 nlrp3 XX cord-023134-y665agnh 806 16 , , , cord-023134-y665agnh 806 17 which which WDT cord-023134-y665agnh 806 18 seems seem VBZ cord-023134-y665agnh 806 19 to to TO cord-023134-y665agnh 806 20 be be VB cord-023134-y665agnh 806 21 crucial crucial JJ cord-023134-y665agnh 806 22 for for IN cord-023134-y665agnh 806 23 the the DT cord-023134-y665agnh 806 24 regulation regulation NN cord-023134-y665agnh 806 25 of of IN cord-023134-y665agnh 806 26 intestinal intestinal JJ cord-023134-y665agnh 806 27 homeostasis homeostasis NN cord-023134-y665agnh 806 28 . . . cord-023134-y665agnh 807 1 Defective defective JJ cord-023134-y665agnh 807 2 NLRP3 nlrp3 XX cord-023134-y665agnh 808 1 signaling signaling NN cord-023134-y665agnh 808 2 has have VBZ cord-023134-y665agnh 808 3 been be VBN cord-023134-y665agnh 808 4 suggested suggest VBN cord-023134-y665agnh 808 5 to to TO cord-023134-y665agnh 808 6 contribute contribute VB cord-023134-y665agnh 808 7 to to IN cord-023134-y665agnh 808 8 IBD IBD NNP cord-023134-y665agnh 808 9 . . . cord-023134-y665agnh 809 1 Additionally additionally RB cord-023134-y665agnh 809 2 , , , cord-023134-y665agnh 809 3 IL-1b IL-1b NNP cord-023134-y665agnh 809 4 , , , cord-023134-y665agnh 809 5 IL-18 IL-18 NNP cord-023134-y665agnh 809 6 and and CC cord-023134-y665agnh 809 7 casp-1 casp-1 NNP cord-023134-y665agnh 809 8 are be VBP cord-023134-y665agnh 809 9 upregulated upregulate VBN cord-023134-y665agnh 809 10 on on IN cord-023134-y665agnh 809 11 the the DT cord-023134-y665agnh 809 12 mRNA mrna NN cord-023134-y665agnh 809 13 and and CC cord-023134-y665agnh 809 14 protein protein NN cord-023134-y665agnh 809 15 level level NN cord-023134-y665agnh 809 16 in in IN cord-023134-y665agnh 809 17 human human JJ cord-023134-y665agnh 809 18 IBD IBD NNP cord-023134-y665agnh 809 19 . . . cord-023134-y665agnh 810 1 So so RB cord-023134-y665agnh 810 2 far far RB cord-023134-y665agnh 810 3 , , , cord-023134-y665agnh 810 4 no no DT cord-023134-y665agnh 810 5 study study NN cord-023134-y665agnh 810 6 has have VBZ cord-023134-y665agnh 810 7 investigated investigate VBN cord-023134-y665agnh 810 8 the the DT cord-023134-y665agnh 810 9 role role NN cord-023134-y665agnh 810 10 of of IN cord-023134-y665agnh 810 11 the the DT cord-023134-y665agnh 810 12 inflammasome inflammasome NN cord-023134-y665agnh 810 13 and and CC cord-023134-y665agnh 810 14 respective respective JJ cord-023134-y665agnh 810 15 down down JJ cord-023134-y665agnh 810 16 - - HYPH cord-023134-y665agnh 810 17 stream stream NN cord-023134-y665agnh 810 18 cytokines cytokine NNS cord-023134-y665agnh 810 19 in in IN cord-023134-y665agnh 810 20 canine canine JJ cord-023134-y665agnh 810 21 IBD IBD NNP cord-023134-y665agnh 810 22 . . . cord-023134-y665agnh 811 1 Thus thus RB cord-023134-y665agnh 811 2 , , , cord-023134-y665agnh 811 3 the the DT cord-023134-y665agnh 811 4 goal goal NN cord-023134-y665agnh 811 5 of of IN cord-023134-y665agnh 811 6 the the DT cord-023134-y665agnh 811 7 current current JJ cord-023134-y665agnh 811 8 study study NN cord-023134-y665agnh 811 9 was be VBD cord-023134-y665agnh 811 10 to to TO cord-023134-y665agnh 811 11 investigate investigate VB cord-023134-y665agnh 811 12 the the DT cord-023134-y665agnh 811 13 expression expression NN cord-023134-y665agnh 811 14 of of IN cord-023134-y665agnh 811 15 inflammasome inflammasome NN cord-023134-y665agnh 811 16 components component NNS cord-023134-y665agnh 811 17 in in IN cord-023134-y665agnh 811 18 duodenal duodenal JJ cord-023134-y665agnh 811 19 tissues tissue NNS cord-023134-y665agnh 811 20 from from IN cord-023134-y665agnh 811 21 dogs dog NNS cord-023134-y665agnh 811 22 with with IN cord-023134-y665agnh 811 23 IBD IBD NNP cord-023134-y665agnh 811 24 compared compare VBN cord-023134-y665agnh 811 25 to to IN cord-023134-y665agnh 811 26 healthy healthy JJ cord-023134-y665agnh 811 27 controls control NNS cord-023134-y665agnh 811 28 . . . cord-023134-y665agnh 812 1 RNA RNA NNP cord-023134-y665agnh 812 2 extraction extraction NN cord-023134-y665agnh 812 3 from from IN cord-023134-y665agnh 812 4 endoscopic endoscopic JJ cord-023134-y665agnh 812 5 biopsies biopsy NNS cord-023134-y665agnh 812 6 ( ( -LRB- cord-023134-y665agnh 812 7 IBD IBD NNP cord-023134-y665agnh 812 8 group group NN cord-023134-y665agnh 812 9 n n NN cord-023134-y665agnh 812 10 = = SYM cord-023134-y665agnh 812 11 25 25 CD cord-023134-y665agnh 812 12 , , , cord-023134-y665agnh 812 13 control control NN cord-023134-y665agnh 812 14 group group NN cord-023134-y665agnh 812 15 n n NN cord-023134-y665agnh 812 16 = = SYM cord-023134-y665agnh 812 17 20 20 CD cord-023134-y665agnh 812 18 ) ) -RRB- cord-023134-y665agnh 812 19 and and CC cord-023134-y665agnh 812 20 reversetranscriptase reversetranscriptase NN cord-023134-y665agnh 812 21 quantitative quantitative JJ cord-023134-y665agnh 812 22 PCR PCR NNP cord-023134-y665agnh 812 23 was be VBD cord-023134-y665agnh 812 24 performed perform VBN cord-023134-y665agnh 812 25 in in IN cord-023134-y665agnh 812 26 a a DT cord-023134-y665agnh 812 27 SYBRGreenbased sybrgreenbased JJ cord-023134-y665agnh 812 28 assay assay NN cord-023134-y665agnh 812 29 using use VBG cord-023134-y665agnh 812 30 specific specific JJ cord-023134-y665agnh 812 31 primers primer NNS cord-023134-y665agnh 812 32 for for IN cord-023134-y665agnh 812 33 the the DT cord-023134-y665agnh 812 34 following follow VBG cord-023134-y665agnh 812 35 canine canine JJ cord-023134-y665agnh 812 36 genes gene NNS cord-023134-y665agnh 812 37 : : : cord-023134-y665agnh 812 38 NLRP3 nlrp3 XX cord-023134-y665agnh 812 39 , , , cord-023134-y665agnh 812 40 casp-1 casp-1 NNP cord-023134-y665agnh 812 41 , , , cord-023134-y665agnh 812 42 IL-1b IL-1b NNP cord-023134-y665agnh 812 43 and and CC cord-023134-y665agnh 812 44 IL-18 IL-18 NNP cord-023134-y665agnh 812 45 . . . cord-023134-y665agnh 813 1 A a DT cord-023134-y665agnh 813 2 10-fold 10-fold JJ cord-023134-y665agnh 813 3 dilution dilution NN cord-023134-y665agnh 813 4 of of IN cord-023134-y665agnh 813 5 plasmid plasmid NN cord-023134-y665agnh 813 6 controls control NNS cord-023134-y665agnh 813 7 for for IN cord-023134-y665agnh 813 8 each each DT cord-023134-y665agnh 813 9 gene gene NN cord-023134-y665agnh 813 10 was be VBD cord-023134-y665agnh 813 11 used use VBN cord-023134-y665agnh 813 12 to to TO cord-023134-y665agnh 813 13 assess assess VB cord-023134-y665agnh 813 14 assay assay NN cord-023134-y665agnh 813 15 efficiency efficiency NN cord-023134-y665agnh 813 16 . . . cord-023134-y665agnh 814 1 Relative relative JJ cord-023134-y665agnh 814 2 quantification quantification NN cord-023134-y665agnh 814 3 of of IN cord-023134-y665agnh 814 4 gene gene NN cord-023134-y665agnh 814 5 expression expression NN cord-023134-y665agnh 814 6 was be VBD cord-023134-y665agnh 814 7 performed perform VBN cord-023134-y665agnh 814 8 using use VBG cord-023134-y665agnh 814 9 three three CD cord-023134-y665agnh 814 10 reference reference NN cord-023134-y665agnh 814 11 genes gene NNS cord-023134-y665agnh 814 12 ( ( -LRB- cord-023134-y665agnh 814 13 GAPDH GAPDH NNP cord-023134-y665agnh 814 14 , , , cord-023134-y665agnh 814 15 SDHA SDHA NNP cord-023134-y665agnh 814 16 , , , cord-023134-y665agnh 814 17 TBP TBP NNP cord-023134-y665agnh 814 18 ) ) -RRB- cord-023134-y665agnh 814 19 . . . cord-023134-y665agnh 815 1 Comparison comparison NN cord-023134-y665agnh 815 2 between between IN cord-023134-y665agnh 815 3 groups group NNS cord-023134-y665agnh 815 4 was be VBD cord-023134-y665agnh 815 5 performed perform VBN cord-023134-y665agnh 815 6 using use VBG cord-023134-y665agnh 815 7 Mann Mann NNP cord-023134-y665agnh 815 8 Whitney Whitney NNP cord-023134-y665agnh 815 9 U U NNP cord-023134-y665agnh 815 10 tests test VBZ cord-023134-y665agnh 815 11 ( ( -LRB- cord-023134-y665agnh 815 12 Graph Graph NNP cord-023134-y665agnh 815 13 Pad Pad NNP cord-023134-y665agnh 815 14 Prism Prism NNP cord-023134-y665agnh 815 15 5 5 CD cord-023134-y665agnh 815 16 ) ) -RRB- cord-023134-y665agnh 815 17 . . . cord-023134-y665agnh 816 1 Significance significance NN cord-023134-y665agnh 816 2 was be VBD cord-023134-y665agnh 816 3 set set VBN cord-023134-y665agnh 816 4 at at IN cord-023134-y665agnh 816 5 p p NN cord-023134-y665agnh 816 6 < < XX cord-023134-y665agnh 816 7 0.05 0.05 CD cord-023134-y665agnh 816 8 . . . cord-023134-y665agnh 817 1 Eight eight CD cord-023134-y665agnh 817 2 samples sample NNS cord-023134-y665agnh 817 3 ( ( -LRB- cord-023134-y665agnh 817 4 5 5 CD cord-023134-y665agnh 817 5 IBD IBD NNP cord-023134-y665agnh 817 6 , , , cord-023134-y665agnh 817 7 3 3 CD cord-023134-y665agnh 817 8 controls control NNS cord-023134-y665agnh 817 9 ) ) -RRB- cord-023134-y665agnh 817 10 had have VBD cord-023134-y665agnh 817 11 to to TO cord-023134-y665agnh 817 12 be be VB cord-023134-y665agnh 817 13 excluded exclude VBN cord-023134-y665agnh 817 14 due due IN cord-023134-y665agnh 817 15 to to IN cord-023134-y665agnh 817 16 poor poor JJ cord-023134-y665agnh 817 17 cDNA cdna NN cord-023134-y665agnh 817 18 quality quality NN cord-023134-y665agnh 817 19 ( ( -LRB- cord-023134-y665agnh 817 20 inadequate inadequate JJ cord-023134-y665agnh 817 21 expression expression NN cord-023134-y665agnh 817 22 of of IN cord-023134-y665agnh 817 23 reference reference NN cord-023134-y665agnh 817 24 genes gene NNS cord-023134-y665agnh 817 25 ) ) -RRB- cord-023134-y665agnh 817 26 . . . cord-023134-y665agnh 818 1 When when WRB cord-023134-y665agnh 818 2 comparing compare VBG cord-023134-y665agnh 818 3 the the DT cord-023134-y665agnh 818 4 remaining remain VBG cord-023134-y665agnh 818 5 samples sample NNS cord-023134-y665agnh 818 6 in in IN cord-023134-y665agnh 818 7 both both DT cord-023134-y665agnh 818 8 groups group NNS cord-023134-y665agnh 818 9 , , , cord-023134-y665agnh 818 10 casp-1 casp-1 NNP cord-023134-y665agnh 818 11 ( ( -LRB- cord-023134-y665agnh 818 12 p p NN cord-023134-y665agnh 818 13 = = SYM cord-023134-y665agnh 818 14 0.001 0.001 CD cord-023134-y665agnh 818 15 ) ) -RRB- cord-023134-y665agnh 818 16 and and CC cord-023134-y665agnh 818 17 NLRP3 nlrp3 XX cord-023134-y665agnh 819 1 ( ( -LRB- cord-023134-y665agnh 819 2 p p NN cord-023134-y665agnh 819 3 < < XX cord-023134-y665agnh 819 4 0.001 0.001 CD cord-023134-y665agnh 819 5 ) ) -RRB- cord-023134-y665agnh 819 6 expression expression NN cord-023134-y665agnh 819 7 was be VBD cord-023134-y665agnh 819 8 significantly significantly RB cord-023134-y665agnh 819 9 lower low JJR cord-023134-y665agnh 819 10 in in IN cord-023134-y665agnh 819 11 IBD IBD NNP cord-023134-y665agnh 819 12 dogs dog NNS cord-023134-y665agnh 819 13 than than IN cord-023134-y665agnh 819 14 controls control NNS cord-023134-y665agnh 819 15 . . . cord-023134-y665agnh 820 1 In in IN cord-023134-y665agnh 820 2 contrast contrast NN cord-023134-y665agnh 820 3 , , , cord-023134-y665agnh 820 4 IL-1b IL-1b NNP cord-023134-y665agnh 820 5 ( ( -LRB- cord-023134-y665agnh 820 6 p p NN cord-023134-y665agnh 820 7 = = SYM cord-023134-y665agnh 820 8 0.138 0.138 CD cord-023134-y665agnh 820 9 ) ) -RRB- cord-023134-y665agnh 820 10 and and CC cord-023134-y665agnh 820 11 IL-18 IL-18 NNP cord-023134-y665agnh 820 12 ( ( -LRB- cord-023134-y665agnh 820 13 p p NN cord-023134-y665agnh 820 14 = = SYM cord-023134-y665agnh 820 15 0.903 0.903 CD cord-023134-y665agnh 820 16 ) ) -RRB- cord-023134-y665agnh 820 17 expression expression NN cord-023134-y665agnh 820 18 was be VBD cord-023134-y665agnh 820 19 not not RB cord-023134-y665agnh 820 20 different different JJ cord-023134-y665agnh 820 21 between between IN cord-023134-y665agnh 820 22 groups group NNS cord-023134-y665agnh 820 23 . . . cord-023134-y665agnh 821 1 Down down IN cord-023134-y665agnh 821 2 - - HYPH cord-023134-y665agnh 821 3 regulation regulation NN cord-023134-y665agnh 821 4 of of IN cord-023134-y665agnh 821 5 NLRP3 nlrp3 NN cord-023134-y665agnh 822 1 and and CC cord-023134-y665agnh 822 2 casp-1 casp-1 NNP cord-023134-y665agnh 822 3 could could MD cord-023134-y665agnh 822 4 be be VB cord-023134-y665agnh 822 5 part part NN cord-023134-y665agnh 822 6 of of IN cord-023134-y665agnh 822 7 a a DT cord-023134-y665agnh 822 8 negative negative JJ cord-023134-y665agnh 822 9 feedback feedback NN cord-023134-y665agnh 822 10 loop loop NN cord-023134-y665agnh 822 11 in in IN cord-023134-y665agnh 822 12 the the DT cord-023134-y665agnh 822 13 pro pro JJ cord-023134-y665agnh 822 14 - - JJ cord-023134-y665agnh 822 15 inflammatory inflammatory JJ cord-023134-y665agnh 822 16 environment environment NN cord-023134-y665agnh 822 17 in in IN cord-023134-y665agnh 822 18 IBD IBD NNP cord-023134-y665agnh 822 19 . . . cord-023134-y665agnh 823 1 Alternatively alternatively RB cord-023134-y665agnh 823 2 , , , cord-023134-y665agnh 823 3 this this DT cord-023134-y665agnh 823 4 could could MD cord-023134-y665agnh 823 5 represent represent VB cord-023134-y665agnh 823 6 general general JJ cord-023134-y665agnh 823 7 disturbances disturbance NNS cord-023134-y665agnh 823 8 in in IN cord-023134-y665agnh 823 9 intestinal intestinal JJ cord-023134-y665agnh 823 10 homeostasis homeostasis NN cord-023134-y665agnh 823 11 or or CC cord-023134-y665agnh 823 12 failure failure NN cord-023134-y665agnh 823 13 to to IN cord-023134-y665agnh 823 14 up up RB cord-023134-y665agnh 823 15 - - HYPH cord-023134-y665agnh 823 16 regulate regulate VB cord-023134-y665agnh 823 17 " " '' cord-023134-y665agnh 823 18 danger danger NN cord-023134-y665agnh 823 19 - - HYPH cord-023134-y665agnh 823 20 signaling signal VBG cord-023134-y665agnh 823 21 pathways"in pathways"in JJ cord-023134-y665agnh 823 22 inflammation inflammation NN cord-023134-y665agnh 823 23 . . . cord-023134-y665agnh 824 1 Final final JJ cord-023134-y665agnh 824 2 conclusions conclusion NNS cord-023134-y665agnh 824 3 might may MD cord-023134-y665agnh 824 4 be be VB cord-023134-y665agnh 824 5 difficult difficult JJ cord-023134-y665agnh 824 6 to to TO cord-023134-y665agnh 824 7 draw draw VB cord-023134-y665agnh 824 8 without without IN cord-023134-y665agnh 824 9 matching match VBG cord-023134-y665agnh 824 10 protein protein NN cord-023134-y665agnh 824 11 data datum NNS cord-023134-y665agnh 824 12 , , , cord-023134-y665agnh 824 13 as as IN cord-023134-y665agnh 824 14 assessing assess VBG cord-023134-y665agnh 824 15 IL-1b IL-1b NNS cord-023134-y665agnh 824 16 and and CC cord-023134-y665agnh 824 17 IL-18 IL-18 NNP cord-023134-y665agnh 824 18 mRNA mRNA NNP cord-023134-y665agnh 824 19 levels level NNS cord-023134-y665agnh 824 20 can can MD cord-023134-y665agnh 824 21 not not RB cord-023134-y665agnh 824 22 give give VB cord-023134-y665agnh 824 23 insight insight NN cord-023134-y665agnh 824 24 into into IN cord-023134-y665agnh 824 25 the the DT cord-023134-y665agnh 824 26 ratio ratio NN cord-023134-y665agnh 824 27 of of IN cord-023134-y665agnh 824 28 " " `` cord-023134-y665agnh 824 29 pro pro JJ cord-023134-y665agnh 824 30 - - JJ cord-023134-y665agnh 824 31 cytokines"to cytokines"to JJ cord-023134-y665agnh 824 32 active active JJ cord-023134-y665agnh 824 33 cytokines cytokine NNS cord-023134-y665agnh 824 34 . . . cord-023134-y665agnh 825 1 Thus thus RB cord-023134-y665agnh 825 2 , , , cord-023134-y665agnh 825 3 investigating investigate VBG cord-023134-y665agnh 825 4 IL-1b IL-1b NNS cord-023134-y665agnh 825 5 and and CC cord-023134-y665agnh 825 6 IL-18 IL-18 NNP cord-023134-y665agnh 825 7 protein protein NN cord-023134-y665agnh 825 8 content content NN cord-023134-y665agnh 825 9 of of IN cord-023134-y665agnh 825 10 canine canine JJ cord-023134-y665agnh 825 11 IBD IBD NNP cord-023134-y665agnh 825 12 tissues tissue NNS cord-023134-y665agnh 825 13 is be VBZ cord-023134-y665agnh 825 14 warranted warrant VBN cord-023134-y665agnh 825 15 in in IN cord-023134-y665agnh 825 16 the the DT cord-023134-y665agnh 825 17 future future NN cord-023134-y665agnh 825 18 . . . cord-023134-y665agnh 826 1 The the DT cord-023134-y665agnh 826 2 trefoil trefoil NN cord-023134-y665agnh 826 3 factor factor NN cord-023134-y665agnh 826 4 family family NN cord-023134-y665agnh 826 5 ( ( -LRB- cord-023134-y665agnh 826 6 TFF TFF NNP cord-023134-y665agnh 826 7 ) ) -RRB- cord-023134-y665agnh 826 8 comprises comprise VBZ cord-023134-y665agnh 826 9 a a DT cord-023134-y665agnh 826 10 group group NN cord-023134-y665agnh 826 11 of of IN cord-023134-y665agnh 826 12 small small JJ cord-023134-y665agnh 826 13 peptides peptide NNS cord-023134-y665agnh 826 14 produced produce VBN cord-023134-y665agnh 826 15 in in IN cord-023134-y665agnh 826 16 goblet goblet NN cord-023134-y665agnh 826 17 cells cell NNS cord-023134-y665agnh 826 18 , , , cord-023134-y665agnh 826 19 which which WDT cord-023134-y665agnh 826 20 are be VBP cord-023134-y665agnh 826 21 crucial crucial JJ cord-023134-y665agnh 826 22 for for IN cord-023134-y665agnh 826 23 epithelial epithelial JJ cord-023134-y665agnh 826 24 restitution restitution NN cord-023134-y665agnh 826 25 and and CC cord-023134-y665agnh 826 26 maintenance maintenance NN cord-023134-y665agnh 826 27 of of IN cord-023134-y665agnh 826 28 tight tight JJ cord-023134-y665agnh 826 29 junction junction NN cord-023134-y665agnh 826 30 function function NN cord-023134-y665agnh 826 31 in in IN cord-023134-y665agnh 826 32 the the DT cord-023134-y665agnh 826 33 gut gut NN cord-023134-y665agnh 826 34 . . . cord-023134-y665agnh 827 1 In in IN cord-023134-y665agnh 827 2 humans human NNS cord-023134-y665agnh 827 3 with with IN cord-023134-y665agnh 827 4 Inflammatory inflammatory JJ cord-023134-y665agnh 827 5 Bowel Bowel NNP cord-023134-y665agnh 827 6 Disease Disease NNP cord-023134-y665agnh 827 7 ( ( -LRB- cord-023134-y665agnh 827 8 IBD IBD NNP cord-023134-y665agnh 827 9 ) ) -RRB- cord-023134-y665agnh 827 10 , , , cord-023134-y665agnh 827 11 TFF TFF NNP cord-023134-y665agnh 827 12 expression expression NN cord-023134-y665agnh 827 13 is be VBZ cord-023134-y665agnh 827 14 up up RB cord-023134-y665agnh 827 15 - - HYPH cord-023134-y665agnh 827 16 regulated regulated JJ cord-023134-y665agnh 827 17 , , , cord-023134-y665agnh 827 18 which which WDT cord-023134-y665agnh 827 19 is be VBZ cord-023134-y665agnh 827 20 thought think VBN cord-023134-y665agnh 827 21 to to TO cord-023134-y665agnh 827 22 represent represent VB cord-023134-y665agnh 827 23 an an DT cord-023134-y665agnh 827 24 unspecific unspecific JJ cord-023134-y665agnh 827 25 repair repair NN cord-023134-y665agnh 827 26 mechanism mechanism NN cord-023134-y665agnh 827 27 . . . cord-023134-y665agnh 828 1 However however RB cord-023134-y665agnh 828 2 , , , cord-023134-y665agnh 828 3 TFFs tff NNS cord-023134-y665agnh 828 4 have have VBP cord-023134-y665agnh 828 5 also also RB cord-023134-y665agnh 828 6 been be VBN cord-023134-y665agnh 828 7 shown show VBN cord-023134-y665agnh 828 8 to to TO cord-023134-y665agnh 828 9 be be VB cord-023134-y665agnh 828 10 involved involve VBN cord-023134-y665agnh 828 11 in in IN cord-023134-y665agnh 828 12 the the DT cord-023134-y665agnh 828 13 local local JJ cord-023134-y665agnh 828 14 control control NN cord-023134-y665agnh 828 15 of of IN cord-023134-y665agnh 828 16 disease disease NN cord-023134-y665agnh 828 17 in in IN cord-023134-y665agnh 828 18 rodent rodent NN cord-023134-y665agnh 828 19 models model NNS cord-023134-y665agnh 828 20 and and CC cord-023134-y665agnh 828 21 in in IN cord-023134-y665agnh 828 22 humans human NNS cord-023134-y665agnh 828 23 . . . cord-023134-y665agnh 829 1 So so RB cord-023134-y665agnh 829 2 far far RB cord-023134-y665agnh 829 3 , , , cord-023134-y665agnh 829 4 there there EX cord-023134-y665agnh 829 5 has have VBZ cord-023134-y665agnh 829 6 been be VBN cord-023134-y665agnh 829 7 no no DT cord-023134-y665agnh 829 8 study study NN cord-023134-y665agnh 829 9 investigating investigate VBG cord-023134-y665agnh 829 10 TFF TFF NNP cord-023134-y665agnh 829 11 expression expression NN cord-023134-y665agnh 829 12 in in IN cord-023134-y665agnh 829 13 the the DT cord-023134-y665agnh 829 14 canine canine JJ cord-023134-y665agnh 829 15 intestine intestine NN cord-023134-y665agnh 829 16 . . . cord-023134-y665agnh 830 1 Thus thus RB cord-023134-y665agnh 830 2 , , , cord-023134-y665agnh 830 3 the the DT cord-023134-y665agnh 830 4 goal goal NN cord-023134-y665agnh 830 5 of of IN cord-023134-y665agnh 830 6 this this DT cord-023134-y665agnh 830 7 study study NN cord-023134-y665agnh 830 8 was be VBD cord-023134-y665agnh 830 9 to to TO cord-023134-y665agnh 830 10 assess assess VB cord-023134-y665agnh 830 11 TFF TFF NNP cord-023134-y665agnh 830 12 expression expression NN cord-023134-y665agnh 830 13 in in IN cord-023134-y665agnh 830 14 gastrointestinal gastrointestinal JJ cord-023134-y665agnh 830 15 tissues tissue NNS cord-023134-y665agnh 830 16 from from IN cord-023134-y665agnh 830 17 dogs dog NNS cord-023134-y665agnh 830 18 with with IN cord-023134-y665agnh 830 19 IBD IBD NNP cord-023134-y665agnh 830 20 and and CC cord-023134-y665agnh 830 21 healthy healthy JJ cord-023134-y665agnh 830 22 dogs dog NNS cord-023134-y665agnh 830 23 . . . cord-023134-y665agnh 831 1 RNA RNA NNP cord-023134-y665agnh 831 2 was be VBD cord-023134-y665agnh 831 3 extracted extract VBN cord-023134-y665agnh 831 4 from from IN cord-023134-y665agnh 831 5 endoscopic endoscopic JJ cord-023134-y665agnh 831 6 duodenal duodenal JJ cord-023134-y665agnh 831 7 ( ( -LRB- cord-023134-y665agnh 831 8 IBD IBD NNP cord-023134-y665agnh 831 9 n n CC cord-023134-y665agnh 831 10 = = SYM cord-023134-y665agnh 831 11 22 22 CD cord-023134-y665agnh 831 12 , , , cord-023134-y665agnh 831 13 healthy healthy JJ cord-023134-y665agnh 831 14 controls control NNS cord-023134-y665agnh 831 15 n n NN cord-023134-y665agnh 831 16 = = SYM cord-023134-y665agnh 831 17 18 18 CD cord-023134-y665agnh 831 18 ) ) -RRB- cord-023134-y665agnh 831 19 and and CC cord-023134-y665agnh 831 20 colonic colonic JJ cord-023134-y665agnh 831 21 biopsies biopsy NNS cord-023134-y665agnh 831 22 ( ( -LRB- cord-023134-y665agnh 831 23 IBD IBD NNP cord-023134-y665agnh 831 24 n n NN cord-023134-y665agnh 831 25 = = SYM cord-023134-y665agnh 831 26 12 12 CD cord-023134-y665agnh 831 27 , , , cord-023134-y665agnh 831 28 controls control VBZ cord-023134-y665agnh 831 29 n n NN cord-023134-y665agnh 831 30 = = SYM cord-023134-y665agnh 831 31 11 11 CD cord-023134-y665agnh 831 32 ) ) -RRB- cord-023134-y665agnh 831 33 and and CC cord-023134-y665agnh 831 34 cDNA cdna NN cord-023134-y665agnh 831 35 generated generate VBN cord-023134-y665agnh 831 36 . . . cord-023134-y665agnh 832 1 Quantitative quantitative JJ cord-023134-y665agnh 832 2 reverse reverse NN cord-023134-y665agnh 832 3 - - HYPH cord-023134-y665agnh 832 4 transcription transcription NN cord-023134-y665agnh 832 5 PCR PCR NNP cord-023134-y665agnh 832 6 was be VBD cord-023134-y665agnh 832 7 performed perform VBN cord-023134-y665agnh 832 8 for for IN cord-023134-y665agnh 832 9 canine canine JJ cord-023134-y665agnh 832 10 TFF1 TFF1 NNP cord-023134-y665agnh 832 11 and and CC cord-023134-y665agnh 832 12 TFF3 TFF3 NNP cord-023134-y665agnh 832 13 in in IN cord-023134-y665agnh 832 14 a a DT cord-023134-y665agnh 832 15 SYBR SYBR NNP cord-023134-y665agnh 832 16 - - HYPH cord-023134-y665agnh 832 17 Green Green NNP cord-023134-y665agnh 832 18 - - HYPH cord-023134-y665agnh 832 19 based base VBN cord-023134-y665agnh 832 20 assay assay NN cord-023134-y665agnh 832 21 . . . cord-023134-y665agnh 833 1 A a DT cord-023134-y665agnh 833 2 10-fold 10-fold JJ cord-023134-y665agnh 833 3 dilution dilution NN cord-023134-y665agnh 833 4 of of IN cord-023134-y665agnh 833 5 plasmid plasmid NN cord-023134-y665agnh 833 6 controls control NNS cord-023134-y665agnh 833 7 for for IN cord-023134-y665agnh 833 8 each each DT cord-023134-y665agnh 833 9 gene gene NN cord-023134-y665agnh 833 10 was be VBD cord-023134-y665agnh 833 11 used use VBN cord-023134-y665agnh 833 12 to to TO cord-023134-y665agnh 833 13 assess assess VB cord-023134-y665agnh 833 14 assay assay NN cord-023134-y665agnh 833 15 efficiency efficiency NN cord-023134-y665agnh 833 16 . . . cord-023134-y665agnh 834 1 Relative relative JJ cord-023134-y665agnh 834 2 quantification quantification NN cord-023134-y665agnh 834 3 of of IN cord-023134-y665agnh 834 4 gene gene NN cord-023134-y665agnh 834 5 expression expression NN cord-023134-y665agnh 834 6 was be VBD cord-023134-y665agnh 834 7 performed perform VBN cord-023134-y665agnh 834 8 using use VBG cord-023134-y665agnh 834 9 three three CD cord-023134-y665agnh 834 10 reference reference NN cord-023134-y665agnh 834 11 genes gene NNS cord-023134-y665agnh 834 12 ( ( -LRB- cord-023134-y665agnh 834 13 GAPDH GAPDH NNP cord-023134-y665agnh 834 14 , , , cord-023134-y665agnh 834 15 SDHA SDHA NNP cord-023134-y665agnh 834 16 , , , cord-023134-y665agnh 834 17 TBP TBP NNP cord-023134-y665agnh 834 18 ) ) -RRB- cord-023134-y665agnh 834 19 . . . cord-023134-y665agnh 835 1 For for IN cord-023134-y665agnh 835 2 statistical statistical JJ cord-023134-y665agnh 835 3 analysis analysis NN cord-023134-y665agnh 835 4 , , , cord-023134-y665agnh 835 5 significance significance NN cord-023134-y665agnh 835 6 was be VBD cord-023134-y665agnh 835 7 set set VBN cord-023134-y665agnh 835 8 at at IN cord-023134-y665agnh 835 9 p p NN cord-023134-y665agnh 835 10 < < XX cord-023134-y665agnh 835 11 0.05 0.05 CD cord-023134-y665agnh 835 12 . . . cord-023134-y665agnh 836 1 Overall overall RB cord-023134-y665agnh 836 2 , , , cord-023134-y665agnh 836 3 TFF1 TFF1 NNP cord-023134-y665agnh 836 4 expression expression NN cord-023134-y665agnh 836 5 was be VBD cord-023134-y665agnh 836 6 significantly significantly RB cord-023134-y665agnh 836 7 different different JJ cord-023134-y665agnh 836 8 across across IN cord-023134-y665agnh 836 9 groups group NNS cord-023134-y665agnh 836 10 ( ( -LRB- cord-023134-y665agnh 836 11 Kruskal Kruskal NNP cord-023134-y665agnh 836 12 Wallis Wallis NNP cord-023134-y665agnh 836 13 p p NN cord-023134-y665agnh 836 14 < < NNP cord-023134-y665agnh 836 15 0.0001 0.0001 CD cord-023134-y665agnh 836 16 ) ) -RRB- cord-023134-y665agnh 836 17 : : : cord-023134-y665agnh 837 1 In in IN cord-023134-y665agnh 837 2 control control NN cord-023134-y665agnh 837 3 dogs dog NNS cord-023134-y665agnh 837 4 , , , cord-023134-y665agnh 837 5 TFF1 TFF1 NNP cord-023134-y665agnh 837 6 expression expression NN cord-023134-y665agnh 837 7 was be VBD cord-023134-y665agnh 837 8 higher high JJR cord-023134-y665agnh 837 9 in in IN cord-023134-y665agnh 837 10 the the DT cord-023134-y665agnh 837 11 colon colon NN cord-023134-y665agnh 837 12 than than IN cord-023134-y665agnh 837 13 in in IN cord-023134-y665agnh 837 14 the the DT cord-023134-y665agnh 837 15 duodenum duodenum NN cord-023134-y665agnh 838 1 ( ( -LRB- cord-023134-y665agnh 838 2 Mann Mann NNP cord-023134-y665agnh 838 3 Whitney Whitney NNP cord-023134-y665agnh 838 4 p p NN cord-023134-y665agnh 838 5 < < XX cord-023134-y665agnh 838 6 0.0001 0.0001 CD cord-023134-y665agnh 838 7 ) ) -RRB- cord-023134-y665agnh 838 8 . . . cord-023134-y665agnh 839 1 When when WRB cord-023134-y665agnh 839 2 comparing compare VBG cord-023134-y665agnh 839 3 IBD IBD NNP cord-023134-y665agnh 839 4 cases case NNS cord-023134-y665agnh 839 5 to to IN cord-023134-y665agnh 839 6 controls control NNS cord-023134-y665agnh 839 7 , , , cord-023134-y665agnh 839 8 duodenal duodenal JJ cord-023134-y665agnh 839 9 TFF1 TFF1 NNP cord-023134-y665agnh 839 10 was be VBD cord-023134-y665agnh 839 11 significantly significantly RB cord-023134-y665agnh 839 12 up up RB cord-023134-y665agnh 839 13 - - HYPH cord-023134-y665agnh 839 14 regulated regulate VBN cord-023134-y665agnh 840 1 ( ( -LRB- cord-023134-y665agnh 840 2 Mann Mann NNP cord-023134-y665agnh 840 3 Whitney Whitney NNP cord-023134-y665agnh 840 4 p p NN cord-023134-y665agnh 841 1 = = LS cord-023134-y665agnh 841 2 0.0001 0.0001 CD cord-023134-y665agnh 841 3 ) ) -RRB- cord-023134-y665agnh 841 4 . . . cord-023134-y665agnh 842 1 TFF3 tff3 JJ cord-023134-y665agnh 842 2 expression expression NN cord-023134-y665agnh 842 3 was be VBD cord-023134-y665agnh 842 4 not not RB cord-023134-y665agnh 842 5 different different JJ cord-023134-y665agnh 842 6 across across IN cord-023134-y665agnh 842 7 groups group NNS cord-023134-y665agnh 842 8 ( ( -LRB- cord-023134-y665agnh 842 9 Kruskal Kruskal NNP cord-023134-y665agnh 842 10 Wallis Wallis NNP cord-023134-y665agnh 842 11 p p NN cord-023134-y665agnh 842 12 = = SYM cord-023134-y665agnh 842 13 0.056 0.056 CD cord-023134-y665agnh 842 14 ) ) -RRB- cord-023134-y665agnh 842 15 . . . cord-023134-y665agnh 843 1 However however RB cord-023134-y665agnh 843 2 , , , cord-023134-y665agnh 843 3 separate separate JJ cord-023134-y665agnh 843 4 analysis analysis NN cord-023134-y665agnh 843 5 of of IN cord-023134-y665agnh 843 6 the the DT cord-023134-y665agnh 843 7 intestinal intestinal JJ cord-023134-y665agnh 843 8 location location NN cord-023134-y665agnh 843 9 showed show VBD cord-023134-y665agnh 843 10 significant significant JJ cord-023134-y665agnh 843 11 down down JJ cord-023134-y665agnh 843 12 - - HYPH cord-023134-y665agnh 843 13 regulation regulation NN cord-023134-y665agnh 843 14 of of IN cord-023134-y665agnh 843 15 TFF3 TFF3 NNP cord-023134-y665agnh 843 16 in in IN cord-023134-y665agnh 843 17 the the DT cord-023134-y665agnh 843 18 colon colon NN cord-023134-y665agnh 843 19 of of IN cord-023134-y665agnh 843 20 IBD IBD NNP cord-023134-y665agnh 843 21 dogs dog NNS cord-023134-y665agnh 843 22 compared compare VBN cord-023134-y665agnh 843 23 to to IN cord-023134-y665agnh 843 24 controls control NNS cord-023134-y665agnh 843 25 ( ( -LRB- cord-023134-y665agnh 843 26 t t NN cord-023134-y665agnh 843 27 - - HYPH cord-023134-y665agnh 843 28 test test NN cord-023134-y665agnh 843 29 p p NN cord-023134-y665agnh 843 30 = = SYM cord-023134-y665agnh 843 31 0.018).This 0.018).this CD cord-023134-y665agnh 843 32 study study NN cord-023134-y665agnh 843 33 demonstrates demonstrate VBZ cord-023134-y665agnh 843 34 evidence evidence NN cord-023134-y665agnh 843 35 for for IN cord-023134-y665agnh 843 36 dysregulation dysregulation NN cord-023134-y665agnh 843 37 of of IN cord-023134-y665agnh 843 38 TFF TFF NNP cord-023134-y665agnh 843 39 gene gene NN cord-023134-y665agnh 843 40 expression expression NN cord-023134-y665agnh 843 41 in in IN cord-023134-y665agnh 843 42 canine canine JJ cord-023134-y665agnh 843 43 IBD IBD NNP cord-023134-y665agnh 843 44 . . . cord-023134-y665agnh 844 1 A a DT cord-023134-y665agnh 844 2 lack lack NN cord-023134-y665agnh 844 3 of of IN cord-023134-y665agnh 844 4 TFF1 TFF1 NNP cord-023134-y665agnh 844 5 could could MD cord-023134-y665agnh 844 6 contribute contribute VB cord-023134-y665agnh 844 7 to to IN cord-023134-y665agnh 844 8 defective defective JJ cord-023134-y665agnh 844 9 epithelial epithelial JJ cord-023134-y665agnh 844 10 barrier barrier NN cord-023134-y665agnh 844 11 function function NN cord-023134-y665agnh 844 12 , , , cord-023134-y665agnh 844 13 causing cause VBG cord-023134-y665agnh 844 14 " " `` cord-023134-y665agnh 844 15 leakiness"of leakiness"of `` cord-023134-y665agnh 844 16 tight tight JJ cord-023134-y665agnh 844 17 junctions junction NNS cord-023134-y665agnh 844 18 . . . cord-023134-y665agnh 845 1 This this DT cord-023134-y665agnh 845 2 increased increase VBN cord-023134-y665agnh 845 3 intestinal intestinal JJ cord-023134-y665agnh 845 4 permeability permeability NN cord-023134-y665agnh 845 5 could could MD cord-023134-y665agnh 845 6 lead lead VB cord-023134-y665agnh 845 7 to to IN cord-023134-y665agnh 845 8 an an DT cord-023134-y665agnh 845 9 increased increase VBN cord-023134-y665agnh 845 10 antigenic antigenic JJ cord-023134-y665agnh 845 11 load load NN cord-023134-y665agnh 845 12 from from IN cord-023134-y665agnh 845 13 microbes microbe NNS cord-023134-y665agnh 845 14 or or CC cord-023134-y665agnh 845 15 food food NN cord-023134-y665agnh 845 16 antigens antigen NNS cord-023134-y665agnh 845 17 , , , cord-023134-y665agnh 845 18 which which WDT cord-023134-y665agnh 845 19 could could MD cord-023134-y665agnh 845 20 perpetuate perpetuate VB cord-023134-y665agnh 845 21 faulty faulty JJ cord-023134-y665agnh 845 22 immune immune JJ cord-023134-y665agnh 845 23 recognition recognition NN cord-023134-y665agnh 845 24 of of IN cord-023134-y665agnh 845 25 microbe microbe NN cord-023134-y665agnh 845 26 - - HYPH cord-023134-y665agnh 845 27 associated associate VBN cord-023134-y665agnh 845 28 molecular molecular JJ cord-023134-y665agnh 845 29 patterns pattern NNS cord-023134-y665agnh 845 30 , , , cord-023134-y665agnh 845 31 thus thus RB cord-023134-y665agnh 845 32 leading lead VBG cord-023134-y665agnh 845 33 to to IN cord-023134-y665agnh 845 34 increased increase VBN cord-023134-y665agnh 845 35 intestinal intestinal JJ cord-023134-y665agnh 845 36 inflammation inflammation NN cord-023134-y665agnh 845 37 . . . cord-023134-y665agnh 846 1 Up up IN cord-023134-y665agnh 846 2 - - HYPH cord-023134-y665agnh 846 3 regulation regulation NN cord-023134-y665agnh 846 4 of of IN cord-023134-y665agnh 846 5 TFF3 TFF3 NNP cord-023134-y665agnh 846 6 in in IN cord-023134-y665agnh 846 7 the the DT cord-023134-y665agnh 846 8 colon colon NN cord-023134-y665agnh 846 9 could could MD cord-023134-y665agnh 846 10 in in IN cord-023134-y665agnh 846 11 turn turn NN cord-023134-y665agnh 846 12 signify signify VB cord-023134-y665agnh 846 13 a a DT cord-023134-y665agnh 846 14 compensatory compensatory JJ cord-023134-y665agnh 846 15 repair repair NN cord-023134-y665agnh 846 16 - - HYPH cord-023134-y665agnh 846 17 mechanism mechanism NN cord-023134-y665agnh 846 18 in in IN cord-023134-y665agnh 846 19 inflammation inflammation NN cord-023134-y665agnh 846 20 . . . cord-023134-y665agnh 847 1 Further further JJ cord-023134-y665agnh 847 2 investigation investigation NN cord-023134-y665agnh 847 3 of of IN cord-023134-y665agnh 847 4 TFF TFF NNP cord-023134-y665agnh 847 5 gene gene NN cord-023134-y665agnh 847 6 or or CC cord-023134-y665agnh 847 7 protein protein NN cord-023134-y665agnh 847 8 expression expression NN cord-023134-y665agnh 847 9 is be VBZ cord-023134-y665agnh 847 10 warranted warrant VBN cord-023134-y665agnh 847 11 in in IN cord-023134-y665agnh 847 12 canine canine JJ cord-023134-y665agnh 847 13 IBD IBD NNP cord-023134-y665agnh 847 14 . . . cord-023134-y665agnh 848 1 Canine canine JJ cord-023134-y665agnh 848 2 Inflammatory inflammatory JJ cord-023134-y665agnh 848 3 bowel bowel NN cord-023134-y665agnh 848 4 disease disease NN cord-023134-y665agnh 848 5 ( ( -LRB- cord-023134-y665agnh 848 6 IBD IBD NNP cord-023134-y665agnh 848 7 ) ) -RRB- cord-023134-y665agnh 848 8 is be VBZ cord-023134-y665agnh 848 9 thought think VBN cord-023134-y665agnh 848 10 to to TO cord-023134-y665agnh 848 11 be be VB cord-023134-y665agnh 848 12 partially partially RB cord-023134-y665agnh 848 13 caused cause VBN cord-023134-y665agnh 848 14 by by IN cord-023134-y665agnh 848 15 an an DT cord-023134-y665agnh 848 16 aberrant aberrant JJ cord-023134-y665agnh 848 17 immune immune JJ cord-023134-y665agnh 848 18 response response NN cord-023134-y665agnh 848 19 towards towards IN cord-023134-y665agnh 848 20 the the DT cord-023134-y665agnh 848 21 intestinal intestinal JJ cord-023134-y665agnh 848 22 microbiome microbiome NN cord-023134-y665agnh 848 23 . . . cord-023134-y665agnh 849 1 In in IN cord-023134-y665agnh 849 2 humans human NNS cord-023134-y665agnh 849 3 and and CC cord-023134-y665agnh 849 4 mice mouse NNS cord-023134-y665agnh 849 5 , , , cord-023134-y665agnh 849 6 administration administration NN cord-023134-y665agnh 849 7 of of IN cord-023134-y665agnh 849 8 probiotics probiotic NNS cord-023134-y665agnh 849 9 can can MD cord-023134-y665agnh 849 10 alleviate alleviate VB cord-023134-y665agnh 849 11 IBD IBD NNP cord-023134-y665agnh 849 12 severity severity NN cord-023134-y665agnh 849 13 and/or and/or CC cord-023134-y665agnh 849 14 prevent prevent VB cord-023134-y665agnh 849 15 relapse relapse NN cord-023134-y665agnh 849 16 by by IN cord-023134-y665agnh 849 17 induction induction NN cord-023134-y665agnh 849 18 of of IN cord-023134-y665agnh 849 19 a a DT cord-023134-y665agnh 849 20 more more RBR cord-023134-y665agnh 849 21 " " '' cord-023134-y665agnh 849 22 tolerant"microenvironment tolerant"microenvironment . cord-023134-y665agnh 849 23 . . . cord-023134-y665agnh 850 1 The the DT cord-023134-y665agnh 850 2 aim aim NN cord-023134-y665agnh 850 3 of of IN cord-023134-y665agnh 850 4 this this DT cord-023134-y665agnh 850 5 study study NN cord-023134-y665agnh 850 6 was be VBD cord-023134-y665agnh 850 7 to to TO cord-023134-y665agnh 850 8 investigate investigate VB cord-023134-y665agnh 850 9 the the DT cord-023134-y665agnh 850 10 effect effect NN cord-023134-y665agnh 850 11 of of IN cord-023134-y665agnh 850 12 probiotic probiotic JJ cord-023134-y665agnh 850 13 Enterococcus Enterococcus NNP cord-023134-y665agnh 850 14 faecium faecium NN cord-023134-y665agnh 850 15 NCIMB NCIMB NNP cord-023134-y665agnh 851 1 10415 10415 CD cord-023134-y665agnh 851 2 E1707 E1707 NNP cord-023134-y665agnh 851 3 ( ( -LRB- cord-023134-y665agnh 851 4 EF EF NNP cord-023134-y665agnh 851 5 ) ) -RRB- cord-023134-y665agnh 851 6 on on IN cord-023134-y665agnh 851 7 gene gene NN cord-023134-y665agnh 851 8 expression expression NN cord-023134-y665agnh 851 9 and and CC cord-023134-y665agnh 851 10 protein protein NN cord-023134-y665agnh 851 11 production production NN cord-023134-y665agnh 851 12 in in IN cord-023134-y665agnh 851 13 canine canine JJ cord-023134-y665agnh 851 14 duodenal duodenal JJ cord-023134-y665agnh 851 15 biopsies biopsy NNS cord-023134-y665agnh 851 16 . . . cord-023134-y665agnh 852 1 Samples sample NNS cord-023134-y665agnh 852 2 from from IN cord-023134-y665agnh 852 3 11 11 CD cord-023134-y665agnh 852 4 healthy healthy JJ cord-023134-y665agnh 852 5 Beagles Beagles NNPS cord-023134-y665agnh 852 6 and and CC cord-023134-y665agnh 852 7 8 8 CD cord-023134-y665agnh 852 8 IBD IBD NNP cord-023134-y665agnh 852 9 dogs dog NNS cord-023134-y665agnh 852 10 were be VBD cord-023134-y665agnh 852 11 cultured cultured JJ cord-023134-y665agnh 852 12 ex ex FW cord-023134-y665agnh 852 13 - - NN cord-023134-y665agnh 852 14 vivo vivo JJ cord-023134-y665agnh 853 1 with with IN cord-023134-y665agnh 853 2 EF EF NNP cord-023134-y665agnh 853 3 ( ( -LRB- cord-023134-y665agnh 853 4 1x10 1x10 CD cord-023134-y665agnh 853 5 8 8 CD cord-023134-y665agnh 853 6 cfu cfu NN cord-023134-y665agnh 853 7 / / SYM cord-023134-y665agnh 853 8 ml ml NNP cord-023134-y665agnh 853 9 ) ) -RRB- cord-023134-y665agnh 853 10 or or CC cord-023134-y665agnh 853 11 sterile sterile JJ cord-023134-y665agnh 853 12 nutrient nutrient NN cord-023134-y665agnh 853 13 broth/ broth/ CD cord-023134-y665agnh 853 14 PBS PBS NNP cord-023134-y665agnh 853 15 ( ( -LRB- cord-023134-y665agnh 853 16 negative negative JJ cord-023134-y665agnh 853 17 control control NN cord-023134-y665agnh 853 18 ) ) -RRB- cord-023134-y665agnh 853 19 for for IN cord-023134-y665agnh 853 20 5 5 CD cord-023134-y665agnh 853 21 hours hour NNS cord-023134-y665agnh 853 22 . . . cord-023134-y665agnh 854 1 RNA rna NN cord-023134-y665agnh 854 2 extraction extraction NN cord-023134-y665agnh 854 3 from from IN cord-023134-y665agnh 854 4 biopsies biopsy NNS cord-023134-y665agnh 854 5 and and CC cord-023134-y665agnh 854 6 reverse reverse JJ cord-023134-y665agnh 854 7 - - HYPH cord-023134-y665agnh 854 8 transcriptase transcriptase NN cord-023134-y665agnh 854 9 quantitative quantitative JJ cord-023134-y665agnh 854 10 PCR PCR NNP cord-023134-y665agnh 854 11 was be VBD cord-023134-y665agnh 854 12 performed perform VBN cord-023134-y665agnh 854 13 in in IN cord-023134-y665agnh 854 14 a a DT cord-023134-y665agnh 854 15 SYBRGreen sybrgreen NN cord-023134-y665agnh 854 16 - - HYPH cord-023134-y665agnh 854 17 based base VBN cord-023134-y665agnh 854 18 assay assay NN cord-023134-y665agnh 854 19 using use VBG cord-023134-y665agnh 854 20 specific specific JJ cord-023134-y665agnh 854 21 primers primer NNS cord-023134-y665agnh 854 22 for for IN cord-023134-y665agnh 854 23 the the DT cord-023134-y665agnh 854 24 following follow VBG cord-023134-y665agnh 854 25 canine canine JJ cord-023134-y665agnh 854 26 genes gene NNS cord-023134-y665agnh 854 27 : : : cord-023134-y665agnh 854 28 TLR2 TLR2 NNP cord-023134-y665agnh 854 29 , , , cord-023134-y665agnh 854 30 TLR4 TLR4 NNP cord-023134-y665agnh 854 31 , , , cord-023134-y665agnh 854 32 TLR5 TLR5 NNP cord-023134-y665agnh 854 33 , , , cord-023134-y665agnh 854 34 TLR9 TLR9 NNP cord-023134-y665agnh 854 35 , , , cord-023134-y665agnh 854 36 IL-17A IL-17A NNP cord-023134-y665agnh 854 37 , , , cord-023134-y665agnh 854 38 IL-22 IL-22 NNP cord-023134-y665agnh 854 39 , , , cord-023134-y665agnh 854 40 IL-10 IL-10 NNP cord-023134-y665agnh 854 41 , , , cord-023134-y665agnh 854 42 TGFb TGFb NNPS cord-023134-y665agnh 854 43 , , , cord-023134-y665agnh 854 44 IL-4 IL-4 NNP cord-023134-y665agnh 854 45 , , , cord-023134-y665agnh 854 46 IFNc IFNc NNP cord-023134-y665agnh 854 47 and and CC cord-023134-y665agnh 854 48 TNFa TNFa NNS cord-023134-y665agnh 854 49 ; ; : cord-023134-y665agnh 854 50 using use VBG cord-023134-y665agnh 854 51 a a DT cord-023134-y665agnh 854 52 10-fold 10-fold JJ cord-023134-y665agnh 854 53 dilution dilution NN cord-023134-y665agnh 854 54 of of IN cord-023134-y665agnh 854 55 plasmid plasmid NN cord-023134-y665agnh 854 56 controls control NNS cord-023134-y665agnh 854 57 for for IN cord-023134-y665agnh 854 58 each each DT cord-023134-y665agnh 854 59 gene gene NN cord-023134-y665agnh 854 60 to to TO cord-023134-y665agnh 854 61 assess assess VB cord-023134-y665agnh 854 62 assay assay NN cord-023134-y665agnh 854 63 efficiency efficiency NN cord-023134-y665agnh 854 64 . . . cord-023134-y665agnh 855 1 Relative relative JJ cord-023134-y665agnh 855 2 quantification quantification NN cord-023134-y665agnh 855 3 of of IN cord-023134-y665agnh 855 4 gene gene NN cord-023134-y665agnh 855 5 expression expression NN cord-023134-y665agnh 855 6 was be VBD cord-023134-y665agnh 855 7 performed perform VBN cord-023134-y665agnh 855 8 using use VBG cord-023134-y665agnh 855 9 three three CD cord-023134-y665agnh 855 10 reference reference NN cord-023134-y665agnh 855 11 genes gene NNS cord-023134-y665agnh 855 12 ( ( -LRB- cord-023134-y665agnh 855 13 GAPDH GAPDH NNP cord-023134-y665agnh 855 14 , , , cord-023134-y665agnh 855 15 SDHA SDHA NNP cord-023134-y665agnh 855 16 , , , cord-023134-y665agnh 855 17 TBP TBP NNP cord-023134-y665agnh 855 18 ) ) -RRB- cord-023134-y665agnh 855 19 . . . cord-023134-y665agnh 856 1 Protein protein NN cord-023134-y665agnh 856 2 content content NN cord-023134-y665agnh 856 3 of of IN cord-023134-y665agnh 856 4 IFNc IFNc NNS cord-023134-y665agnh 856 5 , , , cord-023134-y665agnh 856 6 IL-17A IL-17A NNP cord-023134-y665agnh 856 7 and and CC cord-023134-y665agnh 856 8 TNFa TNFa NNP cord-023134-y665agnh 856 9 was be VBD cord-023134-y665agnh 856 10 measured measure VBN cord-023134-y665agnh 856 11 in in IN cord-023134-y665agnh 856 12 culture culture NN cord-023134-y665agnh 856 13 supernatants supernatant NNS cord-023134-y665agnh 856 14 using use VBG cord-023134-y665agnh 856 15 commercially commercially RB cord-023134-y665agnh 856 16 available available JJ cord-023134-y665agnh 856 17 canine canine JJ cord-023134-y665agnh 856 18 - - HYPH cord-023134-y665agnh 856 19 specific specific JJ cord-023134-y665agnh 856 20 ELISAs elisa NNS cord-023134-y665agnh 856 21 . . . cord-023134-y665agnh 857 1 A a DT cord-023134-y665agnh 857 2 linear linear JJ cord-023134-y665agnh 857 3 mixed mixed JJ cord-023134-y665agnh 857 4 model model NN cord-023134-y665agnh 857 5 for for IN cord-023134-y665agnh 857 6 each each DT cord-023134-y665agnh 857 7 genewith genewith NNP cord-023134-y665agnh 857 8 disease disease NNP cord-023134-y665agnh 857 9 group group NN cord-023134-y665agnh 857 10 and and CC cord-023134-y665agnh 857 11 treatment treatment NN cord-023134-y665agnh 857 12 set set VBN cord-023134-y665agnh 857 13 as as IN cord-023134-y665agnh 857 14 fixed fix VBN cord-023134-y665agnh 857 15 parameters parameter NNS cord-023134-y665agnh 857 16 -was -wa VBD cord-023134-y665agnh 857 17 chosen choose VBN cord-023134-y665agnh 857 18 for for IN cord-023134-y665agnh 857 19 statistical statistical JJ cord-023134-y665agnh 857 20 analysis analysis NN cord-023134-y665agnh 857 21 using use VBG cord-023134-y665agnh 857 22 SPSS SPSS NNP cord-023134-y665agnh 857 23 software software NN cord-023134-y665agnh 857 24 . . . cord-023134-y665agnh 858 1 Significance significance NN cord-023134-y665agnh 858 2 was be VBD cord-023134-y665agnh 858 3 set set VBN cord-023134-y665agnh 858 4 at at IN cord-023134-y665agnh 858 5 p p NN cord-023134-y665agnh 858 6 < < XX cord-023134-y665agnh 858 7 0.05.No 0.05.no XX cord-023134-y665agnh 859 1 significant significant JJ cord-023134-y665agnh 859 2 interaction interaction NN cord-023134-y665agnh 859 3 between between IN cord-023134-y665agnh 859 4 disease disease NN cord-023134-y665agnh 859 5 group group NN cord-023134-y665agnh 859 6 and and CC cord-023134-y665agnh 859 7 treatment treatment NN cord-023134-y665agnh 859 8 was be VBD cord-023134-y665agnh 859 9 observed observe VBN cord-023134-y665agnh 859 10 for for IN cord-023134-y665agnh 859 11 any any DT cord-023134-y665agnh 859 12 gene gene NN cord-023134-y665agnh 859 13 . . . cord-023134-y665agnh 860 1 Only only JJ cord-023134-y665agnh 860 2 expression expression NN cord-023134-y665agnh 860 3 of of IN cord-023134-y665agnh 860 4 IL-4 IL-4 NNP cord-023134-y665agnh 860 5 was be VBD cord-023134-y665agnh 860 6 significantly significantly RB cord-023134-y665agnh 860 7 increased increase VBN cord-023134-y665agnh 860 8 in in IN cord-023134-y665agnh 860 9 IBD IBD NNP cord-023134-y665agnh 860 10 dogs dog NNS cord-023134-y665agnh 860 11 compared compare VBN cord-023134-y665agnh 860 12 to to IN cord-023134-y665agnh 860 13 healthy healthy JJ cord-023134-y665agnh 860 14 dogs dog NNS cord-023134-y665agnh 860 15 ( ( -LRB- cord-023134-y665agnh 860 16 p p NN cord-023134-y665agnh 860 17 = = SYM cord-023134-y665agnh 860 18 0.022 0.022 CD cord-023134-y665agnh 860 19 ) ) -RRB- cord-023134-y665agnh 860 20 in in IN cord-023134-y665agnh 860 21 unstimulated unstimulated JJ cord-023134-y665agnh 860 22 samples sample NNS cord-023134-y665agnh 860 23 . . . cord-023134-y665agnh 861 1 All all DT cord-023134-y665agnh 861 2 other other JJ cord-023134-y665agnh 861 3 significant significant JJ cord-023134-y665agnh 861 4 differences difference NNS cord-023134-y665agnh 861 5 were be VBD cord-023134-y665agnh 861 6 independent independent JJ cord-023134-y665agnh 861 7 of of IN cord-023134-y665agnh 861 8 disease disease NNP cord-023134-y665agnh 861 9 group group NN cord-023134-y665agnh 861 10 , , , cord-023134-y665agnh 861 11 but but CC cord-023134-y665agnh 861 12 depen depen NNP cord-023134-y665agnh 861 13 - - HYPH cord-023134-y665agnh 861 14 dent dent NN cord-023134-y665agnh 861 15 on on IN cord-023134-y665agnh 861 16 treatment treatment NN cord-023134-y665agnh 861 17 with with IN cord-023134-y665agnh 861 18 EF EF NNP cord-023134-y665agnh 861 19 . . . cord-023134-y665agnh 862 1 Expression expression NN cord-023134-y665agnh 862 2 of of IN cord-023134-y665agnh 862 3 the the DT cord-023134-y665agnh 862 4 following following JJ cord-023134-y665agnh 862 5 genes gene NNS cord-023134-y665agnh 862 6 was be VBD cord-023134-y665agnh 862 7 reduced reduce VBN cord-023134-y665agnh 862 8 by by IN cord-023134-y665agnh 862 9 EF EF NNP cord-023134-y665agnh 862 10 treatment treatment NN cord-023134-y665agnh 862 11 : : : cord-023134-y665agnh 862 12 TLR TLR NNP cord-023134-y665agnh 862 13 4 4 CD cord-023134-y665agnh 862 14 ( ( -LRB- cord-023134-y665agnh 862 15 p p NN cord-023134-y665agnh 862 16 = = SYM cord-023134-y665agnh 862 17 0.003 0.003 CD cord-023134-y665agnh 862 18 ) ) -RRB- cord-023134-y665agnh 862 19 , , , cord-023134-y665agnh 862 20 TLR5 TLR5 NNP cord-023134-y665agnh 862 21 ( ( -LRB- cord-023134-y665agnh 862 22 p p NN cord-023134-y665agnh 862 23 = = SYM cord-023134-y665agnh 862 24 0.015 0.015 CD cord-023134-y665agnh 862 25 ) ) -RRB- cord-023134-y665agnh 862 26 , , , cord-023134-y665agnh 862 27 TLR9 TLR9 NNP cord-023134-y665agnh 862 28 ( ( -LRB- cord-023134-y665agnh 862 29 p p NN cord-023134-y665agnh 862 30 = = SYM cord-023134-y665agnh 862 31 0.005 0.005 CD cord-023134-y665agnh 862 32 ) ) -RRB- cord-023134-y665agnh 862 33 , , , cord-023134-y665agnh 862 34 TGFb TGFb NNP cord-023134-y665agnh 862 35 ( ( -LRB- cord-023134-y665agnh 862 36 p p NN cord-023134-y665agnh 862 37 = = SYM cord-023134-y665agnh 862 38 0.006 0.006 CD cord-023134-y665agnh 862 39 ) ) -RRB- cord-023134-y665agnh 862 40 , , , cord-023134-y665agnh 862 41 IFNc IFNc NNP cord-023134-y665agnh 862 42 ( ( -LRB- cord-023134-y665agnh 862 43 p p NN cord-023134-y665agnh 862 44 = = SYM cord-023134-y665agnh 862 45 0.032 0.032 CD cord-023134-y665agnh 862 46 ) ) -RRB- cord-023134-y665agnh 862 47 and and CC cord-023134-y665agnh 862 48 TNFa TNFa NNS cord-023134-y665agnh 862 49 ( ( -LRB- cord-023134-y665agnh 862 50 p p NN cord-023134-y665agnh 862 51 = = SYM cord-023134-y665agnh 862 52 < < XX cord-023134-y665agnh 862 53 0.001 0.001 CD cord-023134-y665agnh 862 54 ) ) -RRB- cord-023134-y665agnh 862 55 . . . cord-023134-y665agnh 863 1 No no DT cord-023134-y665agnh 863 2 significant significant JJ cord-023134-y665agnh 863 3 amounts amount NNS cord-023134-y665agnh 863 4 of of IN cord-023134-y665agnh 863 5 IFNc IFNc NNS cord-023134-y665agnh 863 6 , , , cord-023134-y665agnh 863 7 IL-17A IL-17A NNP cord-023134-y665agnh 863 8 or or CC cord-023134-y665agnh 863 9 TNFa TNFa NNP cord-023134-y665agnh 863 10 protein protein NN cord-023134-y665agnh 863 11 were be VBD cord-023134-y665agnh 863 12 detected detect VBN cord-023134-y665agnh 863 13 in in IN cord-023134-y665agnh 863 14 culture culture NN cord-023134-y665agnh 863 15 supernatants supernatant NNS cord-023134-y665agnh 863 16 . . . cord-023134-y665agnh 864 1 This this DT cord-023134-y665agnh 864 2 is be VBZ cord-023134-y665agnh 864 3 the the DT cord-023134-y665agnh 864 4 first first JJ cord-023134-y665agnh 864 5 study study NN cord-023134-y665agnh 864 6 demonstrating demonstrate VBG cord-023134-y665agnh 864 7 a a DT cord-023134-y665agnh 864 8 profound profound JJ cord-023134-y665agnh 864 9 effect effect NN cord-023134-y665agnh 864 10 of of IN cord-023134-y665agnh 864 11 EF EF NNP cord-023134-y665agnh 864 12 treatment treatment NN cord-023134-y665agnh 864 13 on on IN cord-023134-y665agnh 864 14 gene gene NN cord-023134-y665agnh 864 15 expression expression NN cord-023134-y665agnh 864 16 in in IN cord-023134-y665agnh 864 17 ex ex FW cord-023134-y665agnh 864 18 vivo vivo FW cord-023134-y665agnh 864 19 cultured cultured JJ cord-023134-y665agnh 864 20 canine canine JJ cord-023134-y665agnh 864 21 duodenal duodenal JJ cord-023134-y665agnh 864 22 biopsies biopsy NNS cord-023134-y665agnh 864 23 . . . cord-023134-y665agnh 865 1 Down down IN cord-023134-y665agnh 865 2 - - HYPH cord-023134-y665agnh 865 3 regulation regulation NN cord-023134-y665agnh 865 4 of of IN cord-023134-y665agnh 865 5 several several JJ cord-023134-y665agnh 865 6 genes gene NNS cord-023134-y665agnh 865 7 of of IN cord-023134-y665agnh 865 8 innate innate JJ cord-023134-y665agnh 865 9 immune immune JJ cord-023134-y665agnh 865 10 receptors receptor NNS cord-023134-y665agnh 865 11 and and CC cord-023134-y665agnh 865 12 pro pro JJ cord-023134-y665agnh 865 13 - - JJ cord-023134-y665agnh 865 14 inflammatory inflammatory JJ cord-023134-y665agnh 865 15 cytokines cytokine NNS cord-023134-y665agnh 865 16 was be VBD cord-023134-y665agnh 865 17 observed observe VBN cord-023134-y665agnh 865 18 , , , cord-023134-y665agnh 865 19 with with IN cord-023134-y665agnh 865 20 the the DT cord-023134-y665agnh 865 21 most most RBS cord-023134-y665agnh 865 22 significant significant JJ cord-023134-y665agnh 865 23 effect effect NN cord-023134-y665agnh 865 24 on on IN cord-023134-y665agnh 865 25 suppression suppression NN cord-023134-y665agnh 865 26 of of IN cord-023134-y665agnh 865 27 TNFa TNFa NNP cord-023134-y665agnh 865 28 expression expression NN cord-023134-y665agnh 865 29 . . . cord-023134-y665agnh 866 1 Effects effect NNS cord-023134-y665agnh 866 2 were be VBD cord-023134-y665agnh 866 3 seen see VBN cord-023134-y665agnh 866 4 both both CC cord-023134-y665agnh 866 5 in in IN cord-023134-y665agnh 866 6 healthy healthy JJ cord-023134-y665agnh 866 7 and and CC cord-023134-y665agnh 866 8 in in IN cord-023134-y665agnh 866 9 IBD IBD NNP cord-023134-y665agnh 866 10 dogs dog NNS cord-023134-y665agnh 866 11 . . . cord-023134-y665agnh 867 1 Whether whether IN cord-023134-y665agnh 867 2 this this DT cord-023134-y665agnh 867 3 translates translate VBZ cord-023134-y665agnh 867 4 to to IN cord-023134-y665agnh 867 5 a a DT cord-023134-y665agnh 867 6 beneficial beneficial JJ cord-023134-y665agnh 867 7 effect effect NN cord-023134-y665agnh 867 8 in in IN cord-023134-y665agnh 867 9 a a DT cord-023134-y665agnh 867 10 clinical clinical JJ cord-023134-y665agnh 867 11 situation situation NN cord-023134-y665agnh 867 12 needs need VBZ cord-023134-y665agnh 867 13 further further JJ cord-023134-y665agnh 867 14 investigation investigation NN cord-023134-y665agnh 867 15 . . . cord-023134-y665agnh 868 1 Recent recent JJ cord-023134-y665agnh 868 2 molecular molecular JJ cord-023134-y665agnh 868 3 studies study NNS cord-023134-y665agnh 868 4 have have VBP cord-023134-y665agnh 868 5 revealed reveal VBN cord-023134-y665agnh 868 6 a a DT cord-023134-y665agnh 868 7 highly highly RB cord-023134-y665agnh 868 8 complex complex JJ cord-023134-y665agnh 868 9 bacterial bacterial JJ cord-023134-y665agnh 868 10 microbiota microbiota NN cord-023134-y665agnh 868 11 in in IN cord-023134-y665agnh 868 12 the the DT cord-023134-y665agnh 868 13 intestine intestine NN cord-023134-y665agnh 868 14 of of IN cord-023134-y665agnh 868 15 cats cat NNS cord-023134-y665agnh 868 16 . . . cord-023134-y665agnh 869 1 There there EX cord-023134-y665agnh 869 2 is be VBZ cord-023134-y665agnh 869 3 mounting mount VBG cord-023134-y665agnh 869 4 evidence evidence NN cord-023134-y665agnh 869 5 that that IN cord-023134-y665agnh 869 6 microbes microbe NNS cord-023134-y665agnh 869 7 play play VBP cord-023134-y665agnh 869 8 an an DT cord-023134-y665agnh 869 9 important important JJ cord-023134-y665agnh 869 10 role role NN cord-023134-y665agnh 869 11 in in IN cord-023134-y665agnh 869 12 the the DT cord-023134-y665agnh 869 13 pathogenesis pathogenesis NN cord-023134-y665agnh 869 14 of of IN cord-023134-y665agnh 869 15 chronic chronic JJ cord-023134-y665agnh 869 16 enteropathies enteropathy NNS cord-023134-y665agnh 869 17 , , , cord-023134-y665agnh 869 18 as as IN cord-023134-y665agnh 869 19 compositional compositional JJ cord-023134-y665agnh 869 20 changes change NNS cord-023134-y665agnh 869 21 of of IN cord-023134-y665agnh 869 22 the the DT cord-023134-y665agnh 869 23 intestinal intestinal JJ cord-023134-y665agnh 869 24 bacterial bacterial JJ cord-023134-y665agnh 869 25 ecosystem ecosystem NN cord-023134-y665agnh 869 26 have have VBP cord-023134-y665agnh 869 27 been be VBN cord-023134-y665agnh 869 28 associated associate VBN cord-023134-y665agnh 869 29 with with IN cord-023134-y665agnh 869 30 chronic chronic JJ cord-023134-y665agnh 869 31 intestinal intestinal JJ cord-023134-y665agnh 869 32 inflammation inflammation NN cord-023134-y665agnh 869 33 in in IN cord-023134-y665agnh 869 34 humans human NNS cord-023134-y665agnh 869 35 and and CC cord-023134-y665agnh 869 36 dogs dog NNS cord-023134-y665agnh 869 37 . . . cord-023134-y665agnh 870 1 The the DT cord-023134-y665agnh 870 2 aim aim NN cord-023134-y665agnh 870 3 of of IN cord-023134-y665agnh 870 4 this this DT cord-023134-y665agnh 870 5 study study NN cord-023134-y665agnh 870 6 was be VBD cord-023134-y665agnh 870 7 to to TO cord-023134-y665agnh 870 8 characterize characterize VB cord-023134-y665agnh 870 9 the the DT cord-023134-y665agnh 870 10 bacterial bacterial JJ cord-023134-y665agnh 870 11 microbiota microbiota NN cord-023134-y665agnh 870 12 in in IN cord-023134-y665agnh 870 13 cats cat NNS cord-023134-y665agnh 870 14 with with IN cord-023134-y665agnh 870 15 chronic chronic JJ cord-023134-y665agnh 870 16 enteropathies enteropathy NNS cord-023134-y665agnh 870 17 . . . cord-023134-y665agnh 871 1 Fecal fecal JJ cord-023134-y665agnh 871 2 samples sample NNS cord-023134-y665agnh 871 3 were be VBD cord-023134-y665agnh 871 4 obtained obtain VBN cord-023134-y665agnh 871 5 from from IN cord-023134-y665agnh 871 6 healthy healthy JJ cord-023134-y665agnh 871 7 cats cat NNS cord-023134-y665agnh 871 8 ( ( -LRB- cord-023134-y665agnh 871 9 n=16 n=16 NNP cord-023134-y665agnh 871 10 ) ) -RRB- cord-023134-y665agnh 871 11 and and CC cord-023134-y665agnh 871 12 cats cat NNS cord-023134-y665agnh 871 13 with with IN cord-023134-y665agnh 871 14 histologically histologically RB cord-023134-y665agnh 871 15 confirmed confirm VBN cord-023134-y665agnh 871 16 chronic chronic JJ cord-023134-y665agnh 871 17 enteropathies enteropathy NNS cord-023134-y665agnh 871 18 ( ( -LRB- cord-023134-y665agnh 871 19 n=8 n=8 NN cord-023134-y665agnh 871 20 ) ) -RRB- cord-023134-y665agnh 871 21 . . . cord-023134-y665agnh 872 1 The the DT cord-023134-y665agnh 872 2 bacterial bacterial JJ cord-023134-y665agnh 872 3 composition composition NN cord-023134-y665agnh 872 4 was be VBD cord-023134-y665agnh 872 5 analyzed analyze VBN cord-023134-y665agnh 872 6 by by IN cord-023134-y665agnh 872 7 massive massive JJ cord-023134-y665agnh 872 8 parallel parallel NN cord-023134-y665agnh 872 9 16S 16S NNP cord-023134-y665agnh 872 10 rRNA rrna NN cord-023134-y665agnh 872 11 gene gene NN cord-023134-y665agnh 872 12 454-pyrosequencing 454-pyrosequencing CD cord-023134-y665agnh 872 13 ( ( -LRB- cord-023134-y665agnh 872 14 yielding yield VBG cord-023134-y665agnh 872 15 194,000 194,000 CD cord-023134-y665agnh 872 16 sequencing sequencing NN cord-023134-y665agnh 872 17 tags tag NNS cord-023134-y665agnh 872 18 ) ) -RRB- cord-023134-y665agnh 872 19 , , , cord-023134-y665agnh 872 20 and and CC cord-023134-y665agnh 872 21 selected select VBN cord-023134-y665agnh 872 22 quantitative quantitative JJ cord-023134-y665agnh 872 23 PCR pcr NN cord-023134-y665agnh 872 24 assays assay NNS cord-023134-y665agnh 872 25 . . . cord-023134-y665agnh 873 1 Differences difference NNS cord-023134-y665agnh 873 2 in in IN cord-023134-y665agnh 873 3 microbial microbial JJ cord-023134-y665agnh 873 4 community community NN cord-023134-y665agnh 873 5 structure structure NN cord-023134-y665agnh 873 6 between between IN cord-023134-y665agnh 873 7 healthy healthy JJ cord-023134-y665agnh 873 8 and and CC cord-023134-y665agnh 873 9 diseased diseased JJ cord-023134-y665agnh 873 10 cats cat NNS cord-023134-y665agnh 873 11 were be VBD cord-023134-y665agnh 873 12 assessed assess VBN cord-023134-y665agnh 873 13 by by IN cord-023134-y665agnh 873 14 the the DT cord-023134-y665agnh 873 15 phylogenetic phylogenetic JJ cord-023134-y665agnh 873 16 Unifrac Unifrac NNP cord-023134-y665agnh 873 17 distance distance NN cord-023134-y665agnh 873 18 method method NN cord-023134-y665agnh 873 19 , , , cord-023134-y665agnh 873 20 followed follow VBN cord-023134-y665agnh 873 21 by by IN cord-023134-y665agnh 873 22 Analysis Analysis NNP cord-023134-y665agnh 873 23 of of IN cord-023134-y665agnh 873 24 similarity similarity NN cord-023134-y665agnh 873 25 ( ( -LRB- cord-023134-y665agnh 873 26 ANOSIM ANOSIM NNP cord-023134-y665agnh 873 27 ) ) -RRB- cord-023134-y665agnh 873 28 of of IN cord-023134-y665agnh 873 29 the the DT cord-023134-y665agnh 873 30 distance distance NN cord-023134-y665agnh 873 31 matrix matrix NN cord-023134-y665agnh 873 32 . . . cord-023134-y665agnh 874 1 Differences difference NNS cord-023134-y665agnh 874 2 in in IN cord-023134-y665agnh 874 3 bacterial bacterial JJ cord-023134-y665agnh 874 4 groups group NNS cord-023134-y665agnh 874 5 between between IN cord-023134-y665agnh 874 6 the the DT cord-023134-y665agnh 874 7 disease disease NN cord-023134-y665agnh 874 8 groups group NNS cord-023134-y665agnh 874 9 were be VBD cord-023134-y665agnh 874 10 analyzed analyze VBN cord-023134-y665agnh 874 11 using use VBG cord-023134-y665agnh 874 12 Mann Mann NNP cord-023134-y665agnh 874 13 - - HYPH cord-023134-y665agnh 874 14 Whitney Whitney NNP cord-023134-y665agnh 874 15 U U NNP cord-023134-y665agnh 874 16 tests test VBZ cord-023134-y665agnh 874 17 . . . cord-023134-y665agnh 875 1 The the DT cord-023134-y665agnh 875 2 resulting result VBG cord-023134-y665agnh 875 3 P p NN cord-023134-y665agnh 875 4 - - HYPH cord-023134-y665agnh 875 5 values value NNS cord-023134-y665agnh 875 6 were be VBD cord-023134-y665agnh 875 7 corrected correct VBN cord-023134-y665agnh 875 8 for for IN cord-023134-y665agnh 875 9 multiple multiple JJ cord-023134-y665agnh 875 10 comparisons comparison NNS cord-023134-y665agnh 875 11 using use VBG cord-023134-y665agnh 875 12 the the DT cord-023134-y665agnh 875 13 Benjamini Benjamini NNP cord-023134-y665agnh 875 14 & & CC cord-023134-y665agnh 875 15 Hochberg Hochberg NNP cord-023134-y665agnh 875 16 's 's POS cord-023134-y665agnh 875 17 False False NNP cord-023134-y665agnh 875 18 Discovery Discovery NNP cord-023134-y665agnh 875 19 Rate rate NN cord-023134-y665agnh 875 20 . . . cord-023134-y665agnh 876 1 An an DT cord-023134-y665agnh 876 2 adjusted adjusted JJ cord-023134-y665agnh 876 3 P<0.05 p<0.05 NN cord-023134-y665agnh 876 4 was be VBD cord-023134-y665agnh 876 5 considered consider VBN cord-023134-y665agnh 876 6 for for IN cord-023134-y665agnh 876 7 statistical statistical JJ cord-023134-y665agnh 876 8 significance significance NN cord-023134-y665agnh 876 9 . . . cord-023134-y665agnh 877 1 The the DT cord-023134-y665agnh 877 2 UniFrac UniFrac NNP cord-023134-y665agnh 877 3 distance distance NN cord-023134-y665agnh 877 4 metric metric NN cord-023134-y665agnh 877 5 indicated indicate VBD cord-023134-y665agnh 877 6 no no DT cord-023134-y665agnh 877 7 significant significant JJ cord-023134-y665agnh 877 8 clustering clustering NN cord-023134-y665agnh 877 9 according accord VBG cord-023134-y665agnh 877 10 to to IN cord-023134-y665agnh 877 11 disease disease NN cord-023134-y665agnh 877 12 status status NN cord-023134-y665agnh 877 13 . . . cord-023134-y665agnh 878 1 However however RB cord-023134-y665agnh 878 2 , , , cord-023134-y665agnh 878 3 the the DT cord-023134-y665agnh 878 4 relative relative JJ cord-023134-y665agnh 878 5 proportions proportion NNS cord-023134-y665agnh 878 6 of of IN cord-023134-y665agnh 878 7 sequences sequence NNS cord-023134-y665agnh 878 8 belonging belong VBG cord-023134-y665agnh 878 9 to to IN cord-023134-y665agnh 878 10 Bacteroides Bacteroides NNP cord-023134-y665agnh 878 11 spp spp NNS cord-023134-y665agnh 878 12 . . , cord-023134-y665agnh 878 13 were be VBD cord-023134-y665agnh 878 14 significantly significantly RB cord-023134-y665agnh 878 15 decreased decrease VBN cord-023134-y665agnh 878 16 in in IN cord-023134-y665agnh 878 17 the the DT cord-023134-y665agnh 878 18 cats cat NNS cord-023134-y665agnh 878 19 with with IN cord-023134-y665agnh 878 20 chronic chronic JJ cord-023134-y665agnh 878 21 enteropathies enteropathy NNS cord-023134-y665agnh 878 22 compared compare VBN cord-023134-y665agnh 878 23 to to IN cord-023134-y665agnh 878 24 the the DT cord-023134-y665agnh 878 25 healthy healthy JJ cord-023134-y665agnh 878 26 cats cat NNS cord-023134-y665agnh 878 27 ( ( -LRB- cord-023134-y665agnh 878 28 p=0.02 p=0.02 NN cord-023134-y665agnh 878 29 ) ) -RRB- cord-023134-y665agnh 878 30 . . . cord-023134-y665agnh 879 1 The the DT cord-023134-y665agnh 879 2 employed employ VBN cord-023134-y665agnh 879 3 qPCR qPCR NNP cord-023134-y665agnh 879 4 assays assay NNS cord-023134-y665agnh 879 5 confirmed confirm VBD cord-023134-y665agnh 879 6 the the DT cord-023134-y665agnh 879 7 sequencing sequencing NN cord-023134-y665agnh 879 8 results result NNS cord-023134-y665agnh 879 9 and and CC cord-023134-y665agnh 879 10 also also RB cord-023134-y665agnh 879 11 showed show VBD cord-023134-y665agnh 879 12 a a DT cord-023134-y665agnh 879 13 significant significant JJ cord-023134-y665agnh 879 14 decrease decrease NN cord-023134-y665agnh 879 15 in in IN cord-023134-y665agnh 879 16 proportions proportion NNS cord-023134-y665agnh 879 17 of of IN cord-023134-y665agnh 879 18 Bacteroides Bacteroides NNP cord-023134-y665agnh 879 19 spp spp NNS cord-023134-y665agnh 879 20 . . . cord-023134-y665agnh 880 1 in in IN cord-023134-y665agnh 880 2 the the DT cord-023134-y665agnh 880 3 diseased diseased JJ cord-023134-y665agnh 880 4 cats cat NNS cord-023134-y665agnh 880 5 . . . cord-023134-y665agnh 881 1 In in IN cord-023134-y665agnh 881 2 addition addition NN cord-023134-y665agnh 881 3 , , , cord-023134-y665agnh 881 4 qPCR qPCR NNP cord-023134-y665agnh 881 5 revealed reveal VBD cord-023134-y665agnh 881 6 also also RB cord-023134-y665agnh 881 7 a a DT cord-023134-y665agnh 881 8 significant significant JJ cord-023134-y665agnh 881 9 decrease decrease NN cord-023134-y665agnh 881 10 in in IN cord-023134-y665agnh 881 11 Turicibacter Turicibacter NNP cord-023134-y665agnh 881 12 spp spp NNS cord-023134-y665agnh 881 13 . . . cord-023134-y665agnh 882 1 in in IN cord-023134-y665agnh 882 2 cats cat NNS cord-023134-y665agnh 882 3 with with IN cord-023134-y665agnh 882 4 chronic chronic JJ cord-023134-y665agnh 882 5 enteropathies enteropathy NNS cord-023134-y665agnh 882 6 compared compare VBN cord-023134-y665agnh 882 7 to to IN cord-023134-y665agnh 882 8 the the DT cord-023134-y665agnh 882 9 healthy healthy JJ cord-023134-y665agnh 882 10 cats cat NNS cord-023134-y665agnh 882 11 ( ( -LRB- cord-023134-y665agnh 882 12 p=0.04 p=0.04 NNP cord-023134-y665agnh 882 13 ) ) -RRB- cord-023134-y665agnh 882 14 . . . cord-023134-y665agnh 883 1 No no DT cord-023134-y665agnh 883 2 significant significant JJ cord-023134-y665agnh 883 3 differences difference NNS cord-023134-y665agnh 883 4 in in IN cord-023134-y665agnh 883 5 diversity diversity NN cord-023134-y665agnh 883 6 indices index NNS cord-023134-y665agnh 883 7 were be VBD cord-023134-y665agnh 883 8 observed observe VBN cord-023134-y665agnh 883 9 between between IN cord-023134-y665agnh 883 10 healthy healthy JJ cord-023134-y665agnh 883 11 and and CC cord-023134-y665agnh 883 12 diseased diseased JJ cord-023134-y665agnh 883 13 cats cat NNS cord-023134-y665agnh 883 14 . . . cord-023134-y665agnh 884 1 In in IN cord-023134-y665agnh 884 2 conclusion conclusion NN cord-023134-y665agnh 884 3 , , , cord-023134-y665agnh 884 4 the the DT cord-023134-y665agnh 884 5 here here RB cord-023134-y665agnh 884 6 used use VBN cord-023134-y665agnh 884 7 molecular molecular JJ cord-023134-y665agnh 884 8 approach approach NN cord-023134-y665agnh 884 9 revealed reveal VBD cord-023134-y665agnh 884 10 significant significant JJ cord-023134-y665agnh 884 11 reductions reduction NNS cord-023134-y665agnh 884 12 in in IN cord-023134-y665agnh 884 13 Bacteroides Bacteroides NNP cord-023134-y665agnh 884 14 and and CC cord-023134-y665agnh 884 15 Turicibacter Turicibacter NNP cord-023134-y665agnh 884 16 spp spp NNS cord-023134-y665agnh 884 17 . . . cord-023134-y665agnh 885 1 in in IN cord-023134-y665agnh 885 2 cats cat NNS cord-023134-y665agnh 885 3 with with IN cord-023134-y665agnh 885 4 chronic chronic JJ cord-023134-y665agnh 885 5 enteropathies enteropathy NNS cord-023134-y665agnh 885 6 . . . cord-023134-y665agnh 886 1 Future future JJ cord-023134-y665agnh 886 2 studies study NNS cord-023134-y665agnh 886 3 are be VBP cord-023134-y665agnh 886 4 necessary necessary JJ cord-023134-y665agnh 886 5 to to TO cord-023134-y665agnh 886 6 evaluate evaluate VB cord-023134-y665agnh 886 7 if if IN cord-023134-y665agnh 886 8 these these DT cord-023134-y665agnh 886 9 microbial microbial JJ cord-023134-y665agnh 886 10 changes change NNS cord-023134-y665agnh 886 11 correlate correlate VBP cord-023134-y665agnh 886 12 with with IN cord-023134-y665agnh 886 13 functional functional JJ cord-023134-y665agnh 886 14 changes change NNS cord-023134-y665agnh 886 15 in in IN cord-023134-y665agnh 886 16 the the DT cord-023134-y665agnh 886 17 intestinal intestinal JJ cord-023134-y665agnh 886 18 microbiota microbiota NN cord-023134-y665agnh 886 19 . . . cord-023134-y665agnh 887 1 Campylobacter Campylobacter NNP cord-023134-y665agnh 887 2 spp spp NNS cord-023134-y665agnh 887 3 . . . cord-023134-y665agnh 888 1 represent represent VB cord-023134-y665agnh 888 2 a a DT cord-023134-y665agnh 888 3 common common JJ cord-023134-y665agnh 888 4 cause cause NN cord-023134-y665agnh 888 5 of of IN cord-023134-y665agnh 888 6 gastroenteritis gastroenteritis NN cord-023134-y665agnh 888 7 in in IN cord-023134-y665agnh 888 8 humans human NNS cord-023134-y665agnh 888 9 with with IN cord-023134-y665agnh 888 10 C. C. NNP cord-023134-y665agnh 888 11 jejuni jejuni NNP cord-023134-y665agnh 888 12 and and CC cord-023134-y665agnh 888 13 C. C. NNP cord-023134-y665agnh 888 14 coli coli NNS cord-023134-y665agnh 888 15 considered consider VBN cord-023134-y665agnh 888 16 responsible responsible JJ cord-023134-y665agnh 888 17 for for IN cord-023134-y665agnh 888 18 the the DT cord-023134-y665agnh 888 19 majority majority NN cord-023134-y665agnh 888 20 of of IN cord-023134-y665agnh 888 21 clinical clinical JJ cord-023134-y665agnh 888 22 cases case NNS cord-023134-y665agnh 888 23 . . . cord-023134-y665agnh 889 1 Many many JJ cord-023134-y665agnh 889 2 human human JJ cord-023134-y665agnh 889 3 diagnostic diagnostic JJ cord-023134-y665agnh 889 4 laboratories laboratory NNS cord-023134-y665agnh 889 5 use use VBP cord-023134-y665agnh 889 6 the the DT cord-023134-y665agnh 889 7 ProSpecT ProSpecT NNS cord-023134-y665agnh 889 8 ® ® POS cord-023134-y665agnh 889 9 Campylobacter Campylobacter NNP cord-023134-y665agnh 889 10 Microplate Microplate NNP cord-023134-y665agnh 889 11 Assay Assay NNP cord-023134-y665agnh 889 12 ( ( -LRB- cord-023134-y665agnh 889 13 EIA EIA NNP cord-023134-y665agnh 889 14 ) ) -RRB- cord-023134-y665agnh 889 15 as as IN cord-023134-y665agnh 889 16 a a DT cord-023134-y665agnh 889 17 sole sole JJ cord-023134-y665agnh 889 18 or or CC cord-023134-y665agnh 889 19 screening screening NN cord-023134-y665agnh 889 20 test test NN cord-023134-y665agnh 889 21 for for IN cord-023134-y665agnh 889 22 detection detection NN cord-023134-y665agnh 889 23 of of IN cord-023134-y665agnh 889 24 C. C. NNP cord-023134-y665agnh 889 25 jejuni jejuni NNP cord-023134-y665agnh 889 26 and and CC cord-023134-y665agnh 889 27 C. C. NNP cord-023134-y665agnh 889 28 coli coli NNS cord-023134-y665agnh 889 29 as as IN cord-023134-y665agnh 889 30 this this DT cord-023134-y665agnh 889 31 technique technique NN cord-023134-y665agnh 889 32 is be VBZ cord-023134-y665agnh 889 33 easier easy JJR cord-023134-y665agnh 889 34 , , , cord-023134-y665agnh 889 35 faster fast JJR cord-023134-y665agnh 889 36 and and CC cord-023134-y665agnh 889 37 cheaper cheap JJR cord-023134-y665agnh 889 38 than than IN cord-023134-y665agnh 889 39 Campylobacter Campylobacter NNP cord-023134-y665agnh 889 40 spp spp NNS cord-023134-y665agnh 889 41 . . . cord-023134-y665agnh 890 1 culture culture NN cord-023134-y665agnh 890 2 . . . cord-023134-y665agnh 891 1 C. C. NNP cord-023134-y665agnh 891 2 upsaliensis upsaliensis NNP cord-023134-y665agnh 891 3 can can MD cord-023134-y665agnh 891 4 cause cause VB cord-023134-y665agnh 891 5 a a DT cord-023134-y665agnh 891 6 diarrhoeal diarrhoeal NN cord-023134-y665agnh 891 7 illness illness NN cord-023134-y665agnh 891 8 similar similar JJ cord-023134-y665agnh 891 9 to to IN cord-023134-y665agnh 891 10 that that DT cord-023134-y665agnh 891 11 caused cause VBN cord-023134-y665agnh 891 12 by by IN cord-023134-y665agnh 891 13 C. C. NNP cord-023134-y665agnh 891 14 jejuni jejuni NNP cord-023134-y665agnh 891 15 in in IN cord-023134-y665agnh 891 16 humans human NNS cord-023134-y665agnh 891 17 but but CC cord-023134-y665agnh 891 18 methods method NNS cord-023134-y665agnh 891 19 routinely routinely RB cord-023134-y665agnh 891 20 used use VBN cord-023134-y665agnh 891 21 for for IN cord-023134-y665agnh 891 22 C. C. NNP cord-023134-y665agnh 891 23 jejuni jejuni NNP cord-023134-y665agnh 891 24 and and CC cord-023134-y665agnh 891 25 C. C. NNP cord-023134-y665agnh 891 26 coli coli VBZ cord-023134-y665agnh 891 27 detection detection NN cord-023134-y665agnh 891 28 , , , cord-023134-y665agnh 891 29 including include VBG cord-023134-y665agnh 891 30 the the DT cord-023134-y665agnh 891 31 EIA EIA NNP cord-023134-y665agnh 891 32 , , , cord-023134-y665agnh 891 33 are be VBP cord-023134-y665agnh 891 34 not not RB cord-023134-y665agnh 891 35 optimised optimise VBN cord-023134-y665agnh 891 36 or or CC cord-023134-y665agnh 891 37 have have VBP cord-023134-y665agnh 891 38 not not RB cord-023134-y665agnh 891 39 been be VBN cord-023134-y665agnh 891 40 evaluated evaluate VBN cord-023134-y665agnh 891 41 for for IN cord-023134-y665agnh 891 42 the the DT cord-023134-y665agnh 891 43 detection detection NN cord-023134-y665agnh 891 44 of of IN cord-023134-y665agnh 891 45 other other JJ cord-023134-y665agnh 891 46 Campylobacter Campylobacter NNP cord-023134-y665agnh 891 47 species specie NNS cord-023134-y665agnh 891 48 . . . cord-023134-y665agnh 892 1 C. C. NNP cord-023134-y665agnh 892 2 upsaliensis upsaliensis NNP cord-023134-y665agnh 892 3 and and CC cord-023134-y665agnh 892 4 C. C. NNP cord-023134-y665agnh 892 5 helveticus helveticus NNP cord-023134-y665agnh 892 6 have have VBP cord-023134-y665agnh 892 7 been be VBN cord-023134-y665agnh 892 8 more more RBR cord-023134-y665agnh 892 9 commonly commonly RB cord-023134-y665agnh 892 10 isolated isolate VBN cord-023134-y665agnh 892 11 from from IN cord-023134-y665agnh 892 12 dogs dog NNS cord-023134-y665agnh 892 13 and and CC cord-023134-y665agnh 892 14 cats cat NNS cord-023134-y665agnh 892 15 than than IN cord-023134-y665agnh 892 16 C. C. NNP cord-023134-y665agnh 892 17 jejuni jejuni NNP cord-023134-y665agnh 892 18 and and CC cord-023134-y665agnh 892 19 C. C. NNP cord-023134-y665agnh 892 20 coli coli NNS cord-023134-y665agnh 892 21 in in IN cord-023134-y665agnh 892 22 most most JJS cord-023134-y665agnh 892 23 studies study NNS cord-023134-y665agnh 892 24 . . . cord-023134-y665agnh 893 1 Campylobacter Campylobacter NNP cord-023134-y665agnh 893 2 spp spp NNS cord-023134-y665agnh 893 3 . . . cord-023134-y665agnh 894 1 from from IN cord-023134-y665agnh 894 2 pets pet NNS cord-023134-y665agnh 894 3 are be VBP cord-023134-y665agnh 894 4 potentially potentially RB cord-023134-y665agnh 894 5 zoonotic zoonotic JJ cord-023134-y665agnh 894 6 while while IN cord-023134-y665agnh 894 7 the the DT cord-023134-y665agnh 894 8 pathogenicity pathogenicity NN cord-023134-y665agnh 894 9 in in IN cord-023134-y665agnh 894 10 pets pet NNS cord-023134-y665agnh 894 11 remains remain VBZ cord-023134-y665agnh 894 12 uncertain uncertain JJ cord-023134-y665agnh 894 13 . . . cord-023134-y665agnh 895 1 The the DT cord-023134-y665agnh 895 2 significance significance NN cord-023134-y665agnh 895 3 of of IN cord-023134-y665agnh 895 4 C. C. NNP cord-023134-y665agnh 895 5 upsaliensis upsaliensis NNP cord-023134-y665agnh 895 6 and and CC cord-023134-y665agnh 895 7 C. C. NNP cord-023134-y665agnh 895 8 helveticus helveticus NNP cord-023134-y665agnh 895 9 infections infection NNS cord-023134-y665agnh 895 10 may may MD cord-023134-y665agnh 895 11 be be VB cord-023134-y665agnh 895 12 underestimated underestimate VBN cord-023134-y665agnh 895 13 in in IN cord-023134-y665agnh 895 14 human human JJ cord-023134-y665agnh 895 15 medicine medicine NN cord-023134-y665agnh 895 16 due due IN cord-023134-y665agnh 895 17 to to IN cord-023134-y665agnh 895 18 detection detection NN cord-023134-y665agnh 895 19 methods method NNS cord-023134-y665agnh 895 20 applied apply VBN cord-023134-y665agnh 895 21 . . . cord-023134-y665agnh 896 1 The the DT cord-023134-y665agnh 896 2 aim aim NN cord-023134-y665agnh 896 3 of of IN cord-023134-y665agnh 896 4 this this DT cord-023134-y665agnh 896 5 pilot pilot NN cord-023134-y665agnh 896 6 study study NN cord-023134-y665agnh 896 7 was be VBD cord-023134-y665agnh 896 8 to to TO cord-023134-y665agnh 896 9 assess assess VB cord-023134-y665agnh 896 10 if if IN cord-023134-y665agnh 896 11 the the DT cord-023134-y665agnh 896 12 EIA EIA NNP cord-023134-y665agnh 896 13 detects detect VBZ cord-023134-y665agnh 896 14 C. C. NNP cord-023134-y665agnh 896 15 upsaliensis upsaliensis NNP cord-023134-y665agnh 896 16 and and CC cord-023134-y665agnh 896 17 C. C. NNP cord-023134-y665agnh 896 18 helveticus helveticus NNP cord-023134-y665agnh 896 19 isolated isolate VBN cord-023134-y665agnh 896 20 from from IN cord-023134-y665agnh 896 21 different different JJ cord-023134-y665agnh 896 22 pets pet NNS cord-023134-y665agnh 896 23 in in IN cord-023134-y665agnh 896 24 spiked spiked JJ cord-023134-y665agnh 896 25 human human JJ cord-023134-y665agnh 896 26 clinical clinical JJ cord-023134-y665agnh 896 27 samples sample NNS cord-023134-y665agnh 896 28 . . . cord-023134-y665agnh 897 1 In in IN cord-023134-y665agnh 897 2 addition addition NN cord-023134-y665agnh 897 3 , , , cord-023134-y665agnh 897 4 the the DT cord-023134-y665agnh 897 5 ability ability NN cord-023134-y665agnh 897 6 of of IN cord-023134-y665agnh 897 7 EIA EIA NNP cord-023134-y665agnh 897 8 to to TO cord-023134-y665agnh 897 9 detect detect VB cord-023134-y665agnh 897 10 Campylobacter Campylobacter NNP cord-023134-y665agnh 897 11 spp spp NNS cord-023134-y665agnh 897 12 . . . cord-023134-y665agnh 898 1 in in IN cord-023134-y665agnh 898 2 dog dog NN cord-023134-y665agnh 898 3 and and CC cord-023134-y665agnh 898 4 cat cat NN cord-023134-y665agnh 898 5 faeces faece NNS cord-023134-y665agnh 898 6 was be VBD cord-023134-y665agnh 898 7 assessed assess VBN cord-023134-y665agnh 898 8 . . . cord-023134-y665agnh 899 1 Ten ten CD cord-023134-y665agnh 899 2 clinical clinical JJ cord-023134-y665agnh 899 3 human human JJ cord-023134-y665agnh 899 4 faecal faecal JJ cord-023134-y665agnh 899 5 samples sample NNS cord-023134-y665agnh 899 6 and and CC cord-023134-y665agnh 899 7 two two CD cord-023134-y665agnh 899 8 healthy healthy JJ cord-023134-y665agnh 899 9 dog dog NN cord-023134-y665agnh 899 10 and and CC cord-023134-y665agnh 899 11 cat cat NN cord-023134-y665agnh 899 12 faeces faece NNS cord-023134-y665agnh 899 13 confirmed confirm VBD cord-023134-y665agnh 899 14 negative negative JJ cord-023134-y665agnh 899 15 by by IN cord-023134-y665agnh 899 16 EIA EIA NNP cord-023134-y665agnh 899 17 were be VBD cord-023134-y665agnh 899 18 tested test VBN cord-023134-y665agnh 899 19 by by IN cord-023134-y665agnh 899 20 a a DT cord-023134-y665agnh 899 21 range range NN cord-023134-y665agnh 899 22 of of IN cord-023134-y665agnh 899 23 culture culture NN cord-023134-y665agnh 899 24 methods method NNS cord-023134-y665agnh 899 25 to to TO cord-023134-y665agnh 899 26 exclude exclude VB cord-023134-y665agnh 899 27 presence presence NN cord-023134-y665agnh 899 28 of of IN cord-023134-y665agnh 899 29 Campylobacter Campylobacter NNP cord-023134-y665agnh 899 30 spp spp NNS cord-023134-y665agnh 899 31 . . . cord-023134-y665agnh 900 1 Dilutions dilution NNS cord-023134-y665agnh 900 2 of of IN cord-023134-y665agnh 900 3 eight eight CD cord-023134-y665agnh 900 4 C. C. NNP cord-023134-y665agnh 900 5 upsaliensis upsaliensis NN cord-023134-y665agnh 900 6 , , , cord-023134-y665agnh 900 7 five five CD cord-023134-y665agnh 900 8 C. C. NNP cord-023134-y665agnh 900 9 helveticus helveticus NNP cord-023134-y665agnh 900 10 cultures culture NNS cord-023134-y665agnh 900 11 , , , cord-023134-y665agnh 900 12 and and CC cord-023134-y665agnh 900 13 one one CD cord-023134-y665agnh 900 14 C. C. NNP cord-023134-y665agnh 900 15 jejuni jejuni NNP cord-023134-y665agnh 900 16 and and CC cord-023134-y665agnh 900 17 C. C. NNP cord-023134-y665agnh 900 18 coli coli NNS cord-023134-y665agnh 900 19 culture culture NN cord-023134-y665agnh 900 20 , , , cord-023134-y665agnh 900 21 all all DT cord-023134-y665agnh 900 22 PCR PCR NNP cord-023134-y665agnh 900 23 confirmed confirm VBD cord-023134-y665agnh 900 24 , , , cord-023134-y665agnh 900 25 were be VBD cord-023134-y665agnh 900 26 added add VBN cord-023134-y665agnh 900 27 to to IN cord-023134-y665agnh 900 28 aliquots aliquot NNS cord-023134-y665agnh 900 29 of of IN cord-023134-y665agnh 900 30 faecal faecal JJ cord-023134-y665agnh 900 31 samples sample NNS cord-023134-y665agnh 900 32 to to TO cord-023134-y665agnh 900 33 obtain obtain VB cord-023134-y665agnh 900 34 a a DT cord-023134-y665agnh 900 35 range range NN cord-023134-y665agnh 900 36 of of IN cord-023134-y665agnh 900 37 viable viable JJ cord-023134-y665agnh 900 38 bacteria bacteria NNS cord-023134-y665agnh 900 39 from from IN cord-023134-y665agnh 900 40 10 10 CD cord-023134-y665agnh 900 41 3 3 CD cord-023134-y665agnh 900 42 to to TO cord-023134-y665agnh 900 43 10 10 CD cord-023134-y665agnh 900 44 8 8 CD cord-023134-y665agnh 901 1 CFU CFU NNP cord-023134-y665agnh 901 2 / / SYM cord-023134-y665agnh 901 3 ml ml NN cord-023134-y665agnh 901 4 . . . cord-023134-y665agnh 902 1 EIA EIA NNP cord-023134-y665agnh 902 2 was be VBD cord-023134-y665agnh 902 3 performed perform VBN cord-023134-y665agnh 902 4 following follow VBG cord-023134-y665agnh 902 5 the the DT cord-023134-y665agnh 902 6 manufacturer manufacturer NN cord-023134-y665agnh 902 7 's 's POS cord-023134-y665agnh 902 8 instructions instruction NNS cord-023134-y665agnh 902 9 and and CC cord-023134-y665agnh 902 10 in in IN cord-023134-y665agnh 902 11 duplicates duplicate NNS cord-023134-y665agnh 902 12 . . . cord-023134-y665agnh 903 1 Fifty fifty CD cord-023134-y665agnh 903 2 out out IN cord-023134-y665agnh 903 3 of of IN cord-023134-y665agnh 903 4 82 82 CD cord-023134-y665agnh 903 5 samples sample NNS cord-023134-y665agnh 903 6 tested test VBN cord-023134-y665agnh 903 7 positive positive JJ cord-023134-y665agnh 903 8 by by IN cord-023134-y665agnh 903 9 EIA EIA NNP cord-023134-y665agnh 903 10 at at IN cord-023134-y665agnh 903 11 various various JJ cord-023134-y665agnh 903 12 dilutions dilution NNS cord-023134-y665agnh 903 13 : : : cord-023134-y665agnh 904 1 33/52 33/52 CD cord-023134-y665agnh 904 2 C. C. NNP cord-023134-y665agnh 904 3 upsaliensis upsaliensis NNP cord-023134-y665agnh 904 4 , , , cord-023134-y665agnh 904 5 15/26 15/26 CD cord-023134-y665agnh 904 6 C. C. NNP cord-023134-y665agnh 904 7 helveticus helveticus NNP cord-023134-y665agnh 904 8 , , , cord-023134-y665agnh 904 9 1/2 1/2 CD cord-023134-y665agnh 904 10 of of IN cord-023134-y665agnh 904 11 each each DT cord-023134-y665agnh 904 12 C. C. NNP cord-023134-y665agnh 904 13 jejuni jejuni NNP cord-023134-y665agnh 904 14 and and CC cord-023134-y665agnh 904 15 C. C. NNP cord-023134-y665agnh 904 16 coli coli NNS cord-023134-y665agnh 904 17 . . . cord-023134-y665agnh 905 1 Detection detection NN cord-023134-y665agnh 905 2 limit limit NN cord-023134-y665agnh 905 3 varied varied JJ cord-023134-y665agnh 905 4 between between IN cord-023134-y665agnh 905 5 the the DT cord-023134-y665agnh 905 6 isolates isolate NNS cord-023134-y665agnh 905 7 and and CC cord-023134-y665agnh 905 8 was be VBD cord-023134-y665agnh 905 9 lower low JJR cord-023134-y665agnh 905 10 in in IN cord-023134-y665agnh 905 11 watery watery JJ cord-023134-y665agnh 905 12 than than IN cord-023134-y665agnh 905 13 semi semi JJ cord-023134-y665agnh 905 14 - - JJ cord-023134-y665agnh 905 15 solid solid JJ cord-023134-y665agnh 905 16 faeces faece NNS cord-023134-y665agnh 905 17 . . . cord-023134-y665agnh 906 1 In in IN cord-023134-y665agnh 906 2 conclusion conclusion NN cord-023134-y665agnh 906 3 , , , cord-023134-y665agnh 906 4 EIA EIA NNP cord-023134-y665agnh 906 5 detected detect VBD cord-023134-y665agnh 906 6 C. C. NNP cord-023134-y665agnh 906 7 upsaliensis upsaliensis NNP cord-023134-y665agnh 906 8 and and CC cord-023134-y665agnh 906 9 C. C. NNP cord-023134-y665agnh 906 10 helveticus helveticus NNP cord-023134-y665agnh 906 11 in in IN cord-023134-y665agnh 906 12 spiked spiked JJ cord-023134-y665agnh 906 13 faeces faece NNS cord-023134-y665agnh 906 14 from from IN cord-023134-y665agnh 906 15 human human JJ cord-023134-y665agnh 906 16 clinical clinical JJ cord-023134-y665agnh 906 17 cases case NNS cord-023134-y665agnh 906 18 and and CC cord-023134-y665agnh 906 19 all all DT cord-023134-y665agnh 906 20 Campylobacter Campylobacter NNP cord-023134-y665agnh 906 21 spp spp NNS cord-023134-y665agnh 906 22 . . . cord-023134-y665agnh 907 1 tested test VBN cord-023134-y665agnh 907 2 in in IN cord-023134-y665agnh 907 3 healthy healthy JJ cord-023134-y665agnh 907 4 pets pet NNS cord-023134-y665agnh 907 5 . . . cord-023134-y665agnh 908 1 EIA EIA NNP cord-023134-y665agnh 908 2 should should MD cord-023134-y665agnh 908 3 not not RB cord-023134-y665agnh 908 4 be be VB cord-023134-y665agnh 908 5 used use VBN cord-023134-y665agnh 908 6 as as IN cord-023134-y665agnh 908 7 a a DT cord-023134-y665agnh 908 8 sole sole JJ cord-023134-y665agnh 908 9 detection detection NN cord-023134-y665agnh 908 10 method method NN cord-023134-y665agnh 908 11 and and CC cord-023134-y665agnh 908 12 culture culture NN cord-023134-y665agnh 908 13 methods method NNS cord-023134-y665agnh 908 14 selected select VBN cord-023134-y665agnh 908 15 following follow VBG cord-023134-y665agnh 908 16 a a DT cord-023134-y665agnh 908 17 positive positive JJ cord-023134-y665agnh 908 18 EIA EIA NNP cord-023134-y665agnh 908 19 result result NN cord-023134-y665agnh 908 20 should should MD cord-023134-y665agnh 908 21 enable enable VB cord-023134-y665agnh 908 22 detection detection NN cord-023134-y665agnh 908 23 of of IN cord-023134-y665agnh 908 24 a a DT cord-023134-y665agnh 908 25 wide wide JJ cord-023134-y665agnh 908 26 range range NN cord-023134-y665agnh 908 27 of of IN cord-023134-y665agnh 908 28 Campylobacter Campylobacter NNP cord-023134-y665agnh 908 29 spp spp NNS cord-023134-y665agnh 908 30 . . . cord-023134-y665agnh 909 1 In in IN cord-023134-y665agnh 909 2 addition addition NN cord-023134-y665agnh 909 3 , , , cord-023134-y665agnh 909 4 EIA EIA NNP cord-023134-y665agnh 909 5 may may MD cord-023134-y665agnh 909 6 be be VB cord-023134-y665agnh 909 7 a a DT cord-023134-y665agnh 909 8 useful useful JJ cord-023134-y665agnh 909 9 test test NN cord-023134-y665agnh 909 10 in in IN cord-023134-y665agnh 909 11 pets pet NNS cord-023134-y665agnh 909 12 to to TO cord-023134-y665agnh 909 13 rule rule VB cord-023134-y665agnh 909 14 out out RP cord-023134-y665agnh 909 15 Campylobacter Campylobacter NNP cord-023134-y665agnh 909 16 spp spp NNS cord-023134-y665agnh 909 17 . . . cord-023134-y665agnh 910 1 infection infection NN cord-023134-y665agnh 910 2 and and CC cord-023134-y665agnh 910 3 in in IN cord-023134-y665agnh 910 4 epidemiological epidemiological JJ cord-023134-y665agnh 910 5 investigations investigation NNS cord-023134-y665agnh 910 6 . . . cord-023134-y665agnh 911 1 High high JJ cord-023134-y665agnh 911 2 - - HYPH cord-023134-y665agnh 911 3 Resolution Resolution NNP cord-023134-y665agnh 911 4 Manometry Manometry NNP cord-023134-y665agnh 911 5 ( ( -LRB- cord-023134-y665agnh 911 6 HRM HRM NNP cord-023134-y665agnh 911 7 ) ) -RRB- cord-023134-y665agnh 911 8 is be VBZ cord-023134-y665agnh 911 9 the the DT cord-023134-y665agnh 911 10 gold gold NN cord-023134-y665agnh 911 11 standard standard NN cord-023134-y665agnh 911 12 for for IN cord-023134-y665agnh 911 13 the the DT cord-023134-y665agnh 911 14 evaluation evaluation NN cord-023134-y665agnh 911 15 of of IN cord-023134-y665agnh 911 16 functional functional JJ cord-023134-y665agnh 911 17 esophageal esophageal JJ cord-023134-y665agnh 911 18 motility motility NN cord-023134-y665agnh 911 19 disorders disorder NNS cord-023134-y665agnh 911 20 in in IN cord-023134-y665agnh 911 21 humans human NNS cord-023134-y665agnh 911 22 . . . cord-023134-y665agnh 912 1 No no DT cord-023134-y665agnh 912 2 information information NN cord-023134-y665agnh 912 3 on on IN cord-023134-y665agnh 912 4 this this DT cord-023134-y665agnh 912 5 non non JJ cord-023134-y665agnh 912 6 - - JJ cord-023134-y665agnh 912 7 invasive invasive JJ cord-023134-y665agnh 912 8 technique technique NN cord-023134-y665agnh 912 9 is be VBZ cord-023134-y665agnh 912 10 available available JJ cord-023134-y665agnh 912 11 in in IN cord-023134-y665agnh 912 12 dogs dog NNS cord-023134-y665agnh 912 13 . . . cord-023134-y665agnh 913 1 The the DT cord-023134-y665agnh 913 2 aims aim NNS cord-023134-y665agnh 913 3 of of IN cord-023134-y665agnh 913 4 this this DT cord-023134-y665agnh 913 5 study study NN cord-023134-y665agnh 913 6 were be VBD cord-023134-y665agnh 913 7 to to TO cord-023134-y665agnh 913 8 evaluate evaluate VB cord-023134-y665agnh 913 9 the the DT cord-023134-y665agnh 913 10 feasibility feasibility NN cord-023134-y665agnh 913 11 of of IN cord-023134-y665agnh 913 12 HRM HRM NNP cord-023134-y665agnh 913 13 in in IN cord-023134-y665agnh 913 14 dogs dog NNS cord-023134-y665agnh 913 15 , , , cord-023134-y665agnh 913 16 generate generate VB cord-023134-y665agnh 913 17 first first JJ cord-023134-y665agnh 913 18 normal normal JJ cord-023134-y665agnh 913 19 values value NNS cord-023134-y665agnh 913 20 , , , cord-023134-y665agnh 913 21 and and CC cord-023134-y665agnh 913 22 to to TO cord-023134-y665agnh 913 23 examine examine VB cord-023134-y665agnh 913 24 the the DT cord-023134-y665agnh 913 25 influence influence NN cord-023134-y665agnh 913 26 of of IN cord-023134-y665agnh 913 27 a a DT cord-023134-y665agnh 913 28 standard standard JJ cord-023134-y665agnh 913 29 sedation sedation NN cord-023134-y665agnh 913 30 on on IN cord-023134-y665agnh 913 31 the the DT cord-023134-y665agnh 913 32 esophageal esophageal JJ cord-023134-y665agnh 913 33 pressure pressure NN cord-023134-y665agnh 913 34 profile profile NN cord-023134-y665agnh 913 35 . . . cord-023134-y665agnh 914 1 The the DT cord-023134-y665agnh 914 2 study study NN cord-023134-y665agnh 914 3 population population NN cord-023134-y665agnh 914 4 consisted consist VBD cord-023134-y665agnh 914 5 of of IN cord-023134-y665agnh 914 6 20 20 CD cord-023134-y665agnh 914 7 healthy healthy JJ cord-023134-y665agnh 914 8 adult adult NN cord-023134-y665agnh 914 9 Beagle Beagle NNP cord-023134-y665agnh 914 10 dogs dog NNS cord-023134-y665agnh 914 11 ( ( -LRB- cord-023134-y665agnh 914 12 mean mean VB cord-023134-y665agnh 914 13 BW BW NNP cord-023134-y665agnh 914 14 12.85 12.85 CD cord-023134-y665agnh 914 15 kg kg NNP cord-023134-y665agnh 914 16 ) ) -RRB- cord-023134-y665agnh 914 17 , , , cord-023134-y665agnh 914 18 the the DT cord-023134-y665agnh 914 19 study study NN cord-023134-y665agnh 914 20 protocol protocol NN cord-023134-y665agnh 914 21 was be VBD cord-023134-y665agnh 914 22 approved approve VBN cord-023134-y665agnh 914 23 by by IN cord-023134-y665agnh 914 24 the the DT cord-023134-y665agnh 914 25 local local JJ cord-023134-y665agnh 914 26 ethics ethic NNS cord-023134-y665agnh 914 27 committee committee NN cord-023134-y665agnh 914 28 . . . cord-023134-y665agnh 915 1 HRM HRM NNP cord-023134-y665agnh 915 2 was be VBD cord-023134-y665agnh 915 3 performed perform VBN cord-023134-y665agnh 915 4 in in IN cord-023134-y665agnh 915 5 sitting sit VBG cord-023134-y665agnh 915 6 position position NN cord-023134-y665agnh 915 7 after after IN cord-023134-y665agnh 915 8 a a DT cord-023134-y665agnh 915 9 6-h 6-h CD cord-023134-y665agnh 915 10 fast fast NN cord-023134-y665agnh 915 11 , , , cord-023134-y665agnh 915 12 lidocaine lidocaine NN cord-023134-y665agnh 915 13 jelly jelly NN cord-023134-y665agnh 915 14 at at IN cord-023134-y665agnh 915 15 2 2 CD cord-023134-y665agnh 915 16 % % NN cord-023134-y665agnh 915 17 was be VBD cord-023134-y665agnh 915 18 used use VBN cord-023134-y665agnh 915 19 as as IN cord-023134-y665agnh 915 20 a a DT cord-023134-y665agnh 915 21 lubricant lubricant NN cord-023134-y665agnh 915 22 . . . cord-023134-y665agnh 916 1 A a DT cord-023134-y665agnh 916 2 solid solid JJ cord-023134-y665agnh 916 3 - - HYPH cord-023134-y665agnh 916 4 state state NN cord-023134-y665agnh 916 5 catheter catheter NN cord-023134-y665agnh 916 6 ( ( -LRB- cord-023134-y665agnh 916 7 Sierra Sierra NNP cord-023134-y665agnh 916 8 Scientific Scientific NNP cord-023134-y665agnh 916 9 , , , cord-023134-y665agnh 916 10 2.75 2.75 CD cord-023134-y665agnh 916 11 mm mm NN cord-023134-y665agnh 916 12 diameter diameter NN cord-023134-y665agnh 916 13 ) ) -RRB- cord-023134-y665agnh 916 14 with with IN cord-023134-y665agnh 916 15 36 36 CD cord-023134-y665agnh 916 16 circumferential circumferential JJ cord-023134-y665agnh 916 17 pressure pressure NN cord-023134-y665agnh 916 18 sensors sensor NNS cord-023134-y665agnh 916 19 spaced space VBD cord-023134-y665agnh 916 20 1 1 CD cord-023134-y665agnh 916 21 cm cm NNS cord-023134-y665agnh 916 22 apart apart RB cord-023134-y665agnh 916 23 was be VBD cord-023134-y665agnh 916 24 inserted insert VBN cord-023134-y665agnh 916 25 intranasally intranasally RB cord-023134-y665agnh 916 26 , , , cord-023134-y665agnh 916 27 measurements measurement NNS cord-023134-y665agnh 916 28 were be VBD cord-023134-y665agnh 916 29 started start VBN cord-023134-y665agnh 916 30 after after IN cord-023134-y665agnh 916 31 5 5 CD cord-023134-y665agnh 916 32 minutes minute NNS cord-023134-y665agnh 916 33 adaptation adaptation NN cord-023134-y665agnh 916 34 time time NN cord-023134-y665agnh 916 35 . . . cord-023134-y665agnh 917 1 Real real JJ cord-023134-y665agnh 917 2 - - HYPH cord-023134-y665agnh 917 3 time time NN cord-023134-y665agnh 917 4 pressure pressure NN cord-023134-y665agnh 917 5 imaging imaging NN cord-023134-y665agnh 917 6 during during IN cord-023134-y665agnh 917 7 catheter catheter NN cord-023134-y665agnh 917 8 intubation intubation NN cord-023134-y665agnh 917 9 enabled enable VBD cord-023134-y665agnh 917 10 accurate accurate JJ cord-023134-y665agnh 917 11 placement placement NN cord-023134-y665agnh 917 12 . . . cord-023134-y665agnh 918 1 Each each DT cord-023134-y665agnh 918 2 manometric manometric JJ cord-023134-y665agnh 918 3 protocol protocol NN cord-023134-y665agnh 918 4 included include VBD cord-023134-y665agnh 918 5 5 5 CD cord-023134-y665agnh 918 6 water water NN cord-023134-y665agnh 918 7 and and CC cord-023134-y665agnh 918 8 5 5 CD cord-023134-y665agnh 918 9 canned can VBN cord-023134-y665agnh 918 10 food food NN cord-023134-y665agnh 918 11 bolus bolus NN cord-023134-y665agnh 918 12 swallows swallow VBZ cord-023134-y665agnh 918 13 . . . cord-023134-y665agnh 919 1 The the DT cord-023134-y665agnh 919 2 procedure procedure NN cord-023134-y665agnh 919 3 was be VBD cord-023134-y665agnh 919 4 repeated repeat VBN cord-023134-y665agnh 919 5 30 30 CD cord-023134-y665agnh 919 6 minutes minute NNS cord-023134-y665agnh 919 7 after after IN cord-023134-y665agnh 919 8 standard standard JJ cord-023134-y665agnh 919 9 IM IM NNP cord-023134-y665agnh 919 10 sedation sedation NN cord-023134-y665agnh 919 11 with with IN cord-023134-y665agnh 919 12 acepromazine acepromazine NN cord-023134-y665agnh 919 13 and and CC cord-023134-y665agnh 919 14 buprenorphine buprenorphine NN cord-023134-y665agnh 919 15 . . . cord-023134-y665agnh 920 1 Data datum NNS cord-023134-y665agnh 920 2 were be VBD cord-023134-y665agnh 920 3 analysed analyse VBN cord-023134-y665agnh 920 4 using use VBG cord-023134-y665agnh 920 5 ManoView ManoView NNP cord-023134-y665agnh 920 6 software software NN cord-023134-y665agnh 920 7 and and CC cord-023134-y665agnh 920 8 results result NNS cord-023134-y665agnh 920 9 ( ( -LRB- cord-023134-y665agnh 920 10 awake awake JJ cord-023134-y665agnh 920 11 vs. vs. FW cord-023134-y665agnh 920 12 sedated sedated JJ cord-023134-y665agnh 920 13 ) ) -RRB- cord-023134-y665agnh 920 14 were be VBD cord-023134-y665agnh 920 15 compared compare VBN cord-023134-y665agnh 920 16 using use VBG cord-023134-y665agnh 920 17 the the DT cord-023134-y665agnh 920 18 Wilcoxon Wilcoxon NNP cord-023134-y665agnh 920 19 test test NN cord-023134-y665agnh 920 20 . . . cord-023134-y665agnh 921 1 Statistical statistical JJ cord-023134-y665agnh 921 2 significance significance NN cord-023134-y665agnh 921 3 was be VBD cord-023134-y665agnh 921 4 set set VBN cord-023134-y665agnh 921 5 at at IN cord-023134-y665agnh 921 6 p<0.05.HRM p<0.05.hrm NN cord-023134-y665agnh 921 7 could could MD cord-023134-y665agnh 921 8 successfully successfully RB cord-023134-y665agnh 921 9 be be VB cord-023134-y665agnh 921 10 performed perform VBN cord-023134-y665agnh 921 11 in in IN cord-023134-y665agnh 921 12 12/20 12/20 CD cord-023134-y665agnh 921 13 dogs dog NNS cord-023134-y665agnh 921 14 . . . cord-023134-y665agnh 922 1 Reasons reason NNS cord-023134-y665agnh 922 2 for for IN cord-023134-y665agnh 922 3 unsuccessful unsuccessful JJ cord-023134-y665agnh 922 4 examinations examination NNS cord-023134-y665agnh 922 5 were be VBD cord-023134-y665agnh 922 6 : : : cord-023134-y665agnh 922 7 defence defence NN cord-023134-y665agnh 922 8 reactions reaction NNS cord-023134-y665agnh 922 9 ( ( -LRB- cord-023134-y665agnh 922 10 5 5 CD cord-023134-y665agnh 922 11 ) ) -RRB- cord-023134-y665agnh 922 12 , , , cord-023134-y665agnh 922 13 inability inability NN cord-023134-y665agnh 922 14 to to TO cord-023134-y665agnh 922 15 pass pass VB cord-023134-y665agnh 922 16 through through IN cord-023134-y665agnh 922 17 the the DT cord-023134-y665agnh 922 18 ventral ventral JJ cord-023134-y665agnh 922 19 meatus meatus NN cord-023134-y665agnh 922 20 ( ( -LRB- cord-023134-y665agnh 922 21 2 2 CD cord-023134-y665agnh 922 22 ) ) -RRB- cord-023134-y665agnh 922 23 , , , cord-023134-y665agnh 922 24 reverse reverse NN cord-023134-y665agnh 922 25 sneezing sneezing NN cord-023134-y665agnh 922 26 ( ( -LRB- cord-023134-y665agnh 922 27 1 1 CD cord-023134-y665agnh 922 28 ) ) -RRB- cord-023134-y665agnh 922 29 . . . cord-023134-y665agnh 923 1 Upper upper JJ cord-023134-y665agnh 923 2 esophageal esophageal JJ cord-023134-y665agnh 923 3 sphincter sphincter NN cord-023134-y665agnh 923 4 ( ( -LRB- cord-023134-y665agnh 923 5 UES UES NNP cord-023134-y665agnh 923 6 ) ) -RRB- cord-023134-y665agnh 923 7 characterisation characterisation NN cord-023134-y665agnh 923 8 comprised comprise VBN cord-023134-y665agnh 923 9 : : : cord-023134-y665agnh 923 10 baseline baseline JJ cord-023134-y665agnh 923 11 pressure pressure NN cord-023134-y665agnh 923 12 , , , cord-023134-y665agnh 923 13 residual residual JJ cord-023134-y665agnh 923 14 pressure pressure NN cord-023134-y665agnh 923 15 ( ( -LRB- cord-023134-y665agnh 923 16 nadir nadir NN cord-023134-y665agnh 923 17 of of IN cord-023134-y665agnh 923 18 the the DT cord-023134-y665agnh 923 19 UES UES NNP cord-023134-y665agnh 923 20 relaxation relaxation NN cord-023134-y665agnh 923 21 during during IN cord-023134-y665agnh 923 22 swallowing swallow VBG cord-023134-y665agnh 923 23 ) ) -RRB- cord-023134-y665agnh 923 24 , , , cord-023134-y665agnh 923 25 and and CC cord-023134-y665agnh 923 26 relaxation relaxation NN cord-023134-y665agnh 923 27 duration duration NN cord-023134-y665agnh 923 28 . . . cord-023134-y665agnh 924 1 Tubular tubular JJ cord-023134-y665agnh 924 2 esophageal esophageal JJ cord-023134-y665agnh 924 3 function function NN cord-023134-y665agnh 924 4 characterisation characterisation NN cord-023134-y665agnh 924 5 comprised comprise VBN cord-023134-y665agnh 924 6 : : : cord-023134-y665agnh 924 7 peristaltic peristaltic JJ cord-023134-y665agnh 924 8 con con JJ cord-023134-y665agnh 924 9 - - HYPH cord-023134-y665agnh 924 10 tractile tractile JJ cord-023134-y665agnh 924 11 integral integral JJ cord-023134-y665agnh 924 12 ( ( -LRB- cord-023134-y665agnh 924 13 PCI pci NN cord-023134-y665agnh 924 14 ; ; : cord-023134-y665agnh 924 15 amplitude amplitude NN cord-023134-y665agnh 924 16 x x SYM cord-023134-y665agnh 924 17 duration duration NN cord-023134-y665agnh 924 18 x x NN cord-023134-y665agnh 924 19 length length NN cord-023134-y665agnh 924 20 of of IN cord-023134-y665agnh 924 21 the the DT cord-023134-y665agnh 924 22 contraction contraction NN cord-023134-y665agnh 924 23 wave wave NN cord-023134-y665agnh 924 24 ) ) -RRB- cord-023134-y665agnh 924 25 and and CC cord-023134-y665agnh 924 26 the the DT cord-023134-y665agnh 924 27 bolus bolus NN cord-023134-y665agnh 924 28 transit transit NN cord-023134-y665agnh 924 29 time time NN cord-023134-y665agnh 924 30 ( ( -LRB- cord-023134-y665agnh 924 31 BTT BTT NNP cord-023134-y665agnh 924 32 ) ) -RRB- cord-023134-y665agnh 924 33 . . . cord-023134-y665agnh 925 1 Lower low JJR cord-023134-y665agnh 925 2 esophageal esophageal JJ cord-023134-y665agnh 925 3 sphincter sphincter NN cord-023134-y665agnh 925 4 ( ( -LRB- cord-023134-y665agnh 925 5 LES LES NNP cord-023134-y665agnh 925 6 ) ) -RRB- cord-023134-y665agnh 925 7 characterisation characterisation NN cord-023134-y665agnh 925 8 comprised comprise VBN cord-023134-y665agnh 925 9 : : : cord-023134-y665agnh 925 10 baseline baseline JJ cord-023134-y665agnh 925 11 pressure pressure NN cord-023134-y665agnh 925 12 and and CC cord-023134-y665agnh 925 13 residual residual JJ cord-023134-y665agnh 925 14 pressure pressure NN cord-023134-y665agnh 925 15 ( ( -LRB- cord-023134-y665agnh 925 16 lowest low JJS cord-023134-y665agnh 925 17 continuous continuous JJ cord-023134-y665agnh 925 18 3 3 CD cord-023134-y665agnh 925 19 second second JJ cord-023134-y665agnh 925 20 mean mean NN cord-023134-y665agnh 925 21 LES LES NNP cord-023134-y665agnh 925 22 pressure pressure NN cord-023134-y665agnh 925 23 relative relative JJ cord-023134-y665agnh 925 24 to to IN cord-023134-y665agnh 925 25 intragastric intragastric JJ cord-023134-y665agnh 925 26 pressure pressure NN cord-023134-y665agnh 925 27 during during IN cord-023134-y665agnh 925 28 swallow swallow NN cord-023134-y665agnh 925 29 induced induce VBN cord-023134-y665agnh 925 30 relaxation).The relaxation).The NNP cord-023134-y665agnh 925 31 median median JJ cord-023134-y665agnh 925 32 values value NNS cord-023134-y665agnh 925 33 for for IN cord-023134-y665agnh 925 34 water water NN cord-023134-y665agnh 925 35 / / SYM cord-023134-y665agnh 925 36 food food NN cord-023134-y665agnh 925 37 bolus bolus NN cord-023134-y665agnh 925 38 swallows swallow VBZ cord-023134-y665agnh 925 39 in in IN cord-023134-y665agnh 925 40 awake awake JJ cord-023134-y665agnh 926 1 ( ( -LRB- cord-023134-y665agnh 926 2 sedated sedate VBN cord-023134-y665agnh 926 3 ) ) -RRB- cord-023134-y665agnh 927 1 dogs dog NNS cord-023134-y665agnh 927 2 were be VBD cord-023134-y665agnh 927 3 calculated calculate VBN cord-023134-y665agnh 927 4 i i PRP cord-023134-y665agnh 927 5 ) ) -RRB- cord-023134-y665agnh 927 6 UES UES NNP cord-023134-y665agnh 927 7 : : : cord-023134-y665agnh 927 8 baseline baseline JJ cord-023134-y665agnh 927 9 pressure pressure NN cord-023134-y665agnh 927 10 11.5 11.5 CD cord-023134-y665agnh 927 11 mmHg mmHg NNS cord-023134-y665agnh 927 12 ( ( -LRB- cord-023134-y665agnh 927 13 16.1 16.1 CD cord-023134-y665agnh 927 14 ) ) -RRB- cord-023134-y665agnh 927 15 , , , cord-023134-y665agnh 927 16 residual residual JJ cord-023134-y665agnh 927 17 pressure pressure NN cord-023134-y665agnh 927 18 -2.74/2.73 -2.74/2.73 . cord-023134-y665agnh 927 19 mmHg mmHg NNS cord-023134-y665agnh 927 20 ( ( -LRB- cord-023134-y665agnh 927 21 -2.03/2.53 -2.03/2.53 NN cord-023134-y665agnh 927 22 ) ) -RRB- cord-023134-y665agnh 927 23 and and CC cord-023134-y665agnh 927 24 relaxation relaxation NN cord-023134-y665agnh 927 25 duration duration NN cord-023134-y665agnh 927 26 192.5/245 192.5/245 CD cord-023134-y665agnh 927 27 ms ms NNP cord-023134-y665agnh 927 28 ( ( -LRB- cord-023134-y665agnh 927 29 230.25/324 230.25/324 CD cord-023134-y665agnh 927 30 ) ) -RRB- cord-023134-y665agnh 927 31 ii ii NN cord-023134-y665agnh 927 32 ) ) -RRB- cord-023134-y665agnh 928 1 tubular tubular JJ cord-023134-y665agnh 928 2 esophagus esophagus NN cord-023134-y665agnh 928 3 function function NN cord-023134-y665agnh 928 4 : : : cord-023134-y665agnh 928 5 PCI pci NN cord-023134-y665agnh 928 6 478.15/ 478.15/ CD cord-023134-y665agnh 928 7 1012 1012 CD cord-023134-y665agnh 928 8 mmHg mmhg NN cord-023134-y665agnh 928 9 - - HYPH cord-023134-y665agnh 928 10 cm cm NNS cord-023134-y665agnh 928 11 - - HYPH cord-023134-y665agnh 928 12 s s NN cord-023134-y665agnh 928 13 ( ( -LRB- cord-023134-y665agnh 928 14 525.08/1605.4 525.08/1605.4 CD cord-023134-y665agnh 928 15 ) ) -RRB- cord-023134-y665agnh 928 16 and and CC cord-023134-y665agnh 928 17 BTT BTT NNP cord-023134-y665agnh 928 18 3.7/4.08 3.7/4.08 NNP cord-023134-y665agnh 928 19 ms ms NNP cord-023134-y665agnh 928 20 ( ( -LRB- cord-023134-y665agnh 928 21 4.85/ 4.85/ CD cord-023134-y665agnh 928 22 5.82 5.82 CD cord-023134-y665agnh 928 23 ) ) -RRB- cord-023134-y665agnh 928 24 iii iii NN cord-023134-y665agnh 928 25 ) ) -RRB- cord-023134-y665agnh 928 26 LES LES NNP cord-023134-y665agnh 928 27 : : : cord-023134-y665agnh 928 28 baseline baseline JJ cord-023134-y665agnh 928 29 pressure pressure NN cord-023134-y665agnh 928 30 36.85 36.85 CD cord-023134-y665agnh 928 31 mmHg mmHg NNS cord-023134-y665agnh 928 32 ( ( -LRB- cord-023134-y665agnh 928 33 16.8 16.8 CD cord-023134-y665agnh 928 34 ) ) -RRB- cord-023134-y665agnh 928 35 , , , cord-023134-y665agnh 928 36 residual residual JJ cord-023134-y665agnh 928 37 pressure pressure NN cord-023134-y665agnh 928 38 7.2/5.64 7.2/5.64 CD cord-023134-y665agnh 928 39 mmHg mmHg NNS cord-023134-y665agnh 928 40 ( ( -LRB- cord-023134-y665agnh 928 41 10.83/7 10.83/7 CD cord-023134-y665agnh 928 42 ) ) -RRB- cord-023134-y665agnh 928 43 . . . cord-023134-y665agnh 929 1 Significant significant JJ cord-023134-y665agnh 929 2 differences difference NNS cord-023134-y665agnh 929 3 were be VBD cord-023134-y665agnh 929 4 found find VBN cord-023134-y665agnh 929 5 for for IN cord-023134-y665agnh 929 6 the the DT cord-023134-y665agnh 929 7 UES UES NNP cord-023134-y665agnh 929 8 relaxation relaxation NN cord-023134-y665agnh 929 9 duration duration NN cord-023134-y665agnh 929 10 ( ( -LRB- cord-023134-y665agnh 929 11 water water NN cord-023134-y665agnh 929 12 ) ) -RRB- cord-023134-y665agnh 929 13 ( ( -LRB- cord-023134-y665agnh 929 14 p=0.023 p=0.023 NNP cord-023134-y665agnh 929 15 ) ) -RRB- cord-023134-y665agnh 929 16 and and CC cord-023134-y665agnh 929 17 BTT BTT NNP cord-023134-y665agnh 929 18 ( ( -LRB- cord-023134-y665agnh 929 19 food food NN cord-023134-y665agnh 929 20 bolus bolus NN cord-023134-y665agnh 929 21 ) ) -RRB- cord-023134-y665agnh 930 1 ( ( -LRB- cord-023134-y665agnh 930 2 p=0.008).In p=0.008).In NNP cord-023134-y665agnh 930 3 conclusion conclusion NN cord-023134-y665agnh 930 4 , , , cord-023134-y665agnh 930 5 HRM HRM NNP cord-023134-y665agnh 930 6 is be VBZ cord-023134-y665agnh 930 7 a a DT cord-023134-y665agnh 930 8 feasible feasible JJ cord-023134-y665agnh 930 9 technique technique NN cord-023134-y665agnh 930 10 for for IN cord-023134-y665agnh 930 11 the the DT cord-023134-y665agnh 930 12 evaluation evaluation NN cord-023134-y665agnh 930 13 of of IN cord-023134-y665agnh 930 14 esophageal esophageal JJ cord-023134-y665agnh 930 15 function function NN cord-023134-y665agnh 930 16 in in IN cord-023134-y665agnh 930 17 dogs dog NNS cord-023134-y665agnh 930 18 . . . cord-023134-y665agnh 931 1 Patients patient NNS cord-023134-y665agnh 931 2 that that WDT cord-023134-y665agnh 931 3 require require VBP cord-023134-y665agnh 931 4 sedation sedation NN cord-023134-y665agnh 931 5 can can MD cord-023134-y665agnh 931 6 still still RB cord-023134-y665agnh 931 7 be be VB cord-023134-y665agnh 931 8 examined examine VBN cord-023134-y665agnh 931 9 , , , cord-023134-y665agnh 931 10 however however RB cord-023134-y665agnh 931 11 at at IN cord-023134-y665agnh 931 12 this this DT cord-023134-y665agnh 931 13 point point NN cord-023134-y665agnh 931 14 it -PRON- PRP cord-023134-y665agnh 931 15 is be VBZ cord-023134-y665agnh 931 16 not not RB cord-023134-y665agnh 931 17 clear clear JJ cord-023134-y665agnh 931 18 if if IN cord-023134-y665agnh 931 19 sedation sedation NN cord-023134-y665agnh 931 20 would would MD cord-023134-y665agnh 931 21 affect affect VB cord-023134-y665agnh 931 22 the the DT cord-023134-y665agnh 931 23 assessment assessment NN cord-023134-y665agnh 931 24 of of IN cord-023134-y665agnh 931 25 motility motility NN cord-023134-y665agnh 931 26 disorders disorder NNS cord-023134-y665agnh 931 27 in in IN cord-023134-y665agnh 931 28 dysphagic dysphagic JJ cord-023134-y665agnh 931 29 dogs dog NNS cord-023134-y665agnh 931 30 . . . cord-023134-y665agnh 932 1 In in IN cord-023134-y665agnh 932 2 humans human NNS cord-023134-y665agnh 932 3 ambulatory ambulatory JJ cord-023134-y665agnh 932 4 intraesophageal intraesophageal NN cord-023134-y665agnh 932 5 pH ph NN cord-023134-y665agnh 932 6 - - HYPH cord-023134-y665agnh 932 7 monitoring monitoring NN cord-023134-y665agnh 932 8 utilizing utilize VBG cord-023134-y665agnh 932 9 the the DT cord-023134-y665agnh 932 10 Bravo Bravo NNP cord-023134-y665agnh 933 1 ® ® JJ cord-023134-y665agnh 933 2 capsule capsule NN cord-023134-y665agnh 933 3 is be VBZ cord-023134-y665agnh 933 4 the the DT cord-023134-y665agnh 933 5 standard standard JJ cord-023134-y665agnh 933 6 test test NN cord-023134-y665agnh 933 7 for for IN cord-023134-y665agnh 933 8 establishing establish VBG cord-023134-y665agnh 933 9 pathological pathological JJ cord-023134-y665agnh 933 10 gastroesophageal gastroesophageal JJ cord-023134-y665agnh 933 11 reflux reflux NN cord-023134-y665agnh 933 12 ( ( -LRB- cord-023134-y665agnh 933 13 GER GER NNP cord-023134-y665agnh 933 14 ) ) -RRB- cord-023134-y665agnh 933 15 . . . cord-023134-y665agnh 934 1 This this DT cord-023134-y665agnh 934 2 technique technique NN cord-023134-y665agnh 934 3 not not RB cord-023134-y665agnh 934 4 only only RB cord-023134-y665agnh 934 5 provides provide VBZ cord-023134-y665agnh 934 6 information information NN cord-023134-y665agnh 934 7 on on IN cord-023134-y665agnh 934 8 esophageal esophageal JJ cord-023134-y665agnh 934 9 acid acid NN cord-023134-y665agnh 934 10 exposure exposure NN cord-023134-y665agnh 934 11 , , , cord-023134-y665agnh 934 12 but but CC cord-023134-y665agnh 934 13 is be VBZ cord-023134-y665agnh 934 14 also also RB cord-023134-y665agnh 934 15 able able JJ cord-023134-y665agnh 934 16 to to TO cord-023134-y665agnh 934 17 assess assess VB cord-023134-y665agnh 934 18 symptoms symptom NNS cord-023134-y665agnh 934 19 associated associate VBN cord-023134-y665agnh 934 20 with with IN cord-023134-y665agnh 934 21 GER GER NNP cord-023134-y665agnh 934 22 . . . cord-023134-y665agnh 935 1 In in IN cord-023134-y665agnh 935 2 dogs dog NNS cord-023134-y665agnh 935 3 GER GER NNP cord-023134-y665agnh 935 4 is be VBZ cord-023134-y665agnh 935 5 poorly poorly RB cord-023134-y665agnh 935 6 understood understand VBN cord-023134-y665agnh 935 7 and and CC cord-023134-y665agnh 935 8 it -PRON- PRP cord-023134-y665agnh 935 9 is be VBZ cord-023134-y665agnh 935 10 not not RB cord-023134-y665agnh 935 11 clear clear JJ cord-023134-y665agnh 935 12 if if IN cord-023134-y665agnh 935 13 GER GER NNP cord-023134-y665agnh 935 14 actually actually RB cord-023134-y665agnh 935 15 represents represent VBZ cord-023134-y665agnh 935 16 a a DT cord-023134-y665agnh 935 17 clinically clinically RB cord-023134-y665agnh 935 18 relevant relevant JJ cord-023134-y665agnh 935 19 problem problem NN cord-023134-y665agnh 935 20 . . . cord-023134-y665agnh 936 1 The the DT cord-023134-y665agnh 936 2 goals goal NNS cord-023134-y665agnh 936 3 of of IN cord-023134-y665agnh 936 4 this this DT cord-023134-y665agnh 936 5 study study NN cord-023134-y665agnh 936 6 were be VBD cord-023134-y665agnh 936 7 to to TO cord-023134-y665agnh 936 8 examine examine VB cord-023134-y665agnh 936 9 the the DT cord-023134-y665agnh 936 10 canine canine JJ cord-023134-y665agnh 936 11 esophageal esophageal NN cord-023134-y665agnh 936 12 pH ph NN cord-023134-y665agnh 936 13 milieu milieu NN cord-023134-y665agnh 936 14 in in IN cord-023134-y665agnh 936 15 health health NN cord-023134-y665agnh 936 16 and and CC cord-023134-y665agnh 936 17 to to TO cord-023134-y665agnh 936 18 examine examine VB cord-023134-y665agnh 936 19 esophageal esophageal JJ cord-023134-y665agnh 936 20 pH ph NN cord-023134-y665agnh 936 21 in in IN cord-023134-y665agnh 936 22 dogs dog NNS cord-023134-y665agnh 936 23 presenting present VBG cord-023134-y665agnh 936 24 with with IN cord-023134-y665agnh 936 25 signs sign NNS cord-023134-y665agnh 936 26 commonly commonly RB cord-023134-y665agnh 936 27 attributed attribute VBN cord-023134-y665agnh 936 28 to to IN cord-023134-y665agnh 936 29 GER GER NNP cord-023134-y665agnh 936 30 in in IN cord-023134-y665agnh 936 31 the the DT cord-023134-y665agnh 936 32 veterinary veterinary JJ cord-023134-y665agnh 936 33 literature literature NN cord-023134-y665agnh 936 34 . . . cord-023134-y665agnh 937 1 Thirteen thirteen CD cord-023134-y665agnh 937 2 client client NN cord-023134-y665agnh 937 3 - - HYPH cord-023134-y665agnh 937 4 owned own VBN cord-023134-y665agnh 937 5 dogs dog NNS cord-023134-y665agnh 937 6 ( ( -LRB- cord-023134-y665agnh 937 7 COD COD NNP cord-023134-y665agnh 937 8 ) ) -RRB- cord-023134-y665agnh 937 9 of of IN cord-023134-y665agnh 937 10 various various JJ cord-023134-y665agnh 937 11 breeds breed NNS cord-023134-y665agnh 937 12 ( ( -LRB- cord-023134-y665agnh 937 13 median median JJ cord-023134-y665agnh 937 14 BW BW NNP cord-023134-y665agnh 937 15 20.3 20.3 CD cord-023134-y665agnh 937 16 kg kg NNS cord-023134-y665agnh 937 17 , , , cord-023134-y665agnh 937 18 6.1 6.1 CD cord-023134-y665agnh 937 19 - - SYM cord-023134-y665agnh 937 20 45 45 CD cord-023134-y665agnh 937 21 ; ; : cord-023134-y665agnh 937 22 median median JJ cord-023134-y665agnh 937 23 age age NN cord-023134-y665agnh 937 24 5y 5y NN cord-023134-y665agnh 937 25 , , , cord-023134-y665agnh 937 26 1 1 CD cord-023134-y665agnh 937 27 - - SYM cord-023134-y665agnh 937 28 11 11 CD cord-023134-y665agnh 937 29 ) ) -RRB- cord-023134-y665agnh 937 30 were be VBD cord-023134-y665agnh 937 31 included include VBN cord-023134-y665agnh 937 32 . . . cord-023134-y665agnh 938 1 Clinical clinical JJ cord-023134-y665agnh 938 2 signs sign NNS cord-023134-y665agnh 938 3 ultimately ultimately RB cord-023134-y665agnh 938 4 leading lead VBG cord-023134-y665agnh 938 5 to to IN cord-023134-y665agnh 938 6 pH ph NN cord-023134-y665agnh 938 7 - - HYPH cord-023134-y665agnh 938 8 monitoring monitoring NN cord-023134-y665agnh 938 9 comprised comprise VBN cord-023134-y665agnh 938 10 : : : cord-023134-y665agnh 938 11 lipsmacking lipsmacking NNP cord-023134-y665agnh 938 12 ( ( -LRB- cord-023134-y665agnh 938 13 6 6 CD cord-023134-y665agnh 938 14 ) ) -RRB- cord-023134-y665agnh 938 15 , , , cord-023134-y665agnh 938 16 repeated repeat VBD cord-023134-y665agnh 938 17 swallowing swallowing NN cord-023134-y665agnh 938 18 motions motion NNS cord-023134-y665agnh 938 19 ( ( -LRB- cord-023134-y665agnh 938 20 3 3 CD cord-023134-y665agnh 938 21 ) ) -RRB- cord-023134-y665agnh 938 22 , , , cord-023134-y665agnh 938 23 chronic chronic JJ cord-023134-y665agnh 938 24 vomiting vomiting NN cord-023134-y665agnh 938 25 ( ( -LRB- cord-023134-y665agnh 938 26 3 3 CD cord-023134-y665agnh 938 27 ) ) -RRB- cord-023134-y665agnh 938 28 , , , cord-023134-y665agnh 938 29 cough cough NN cord-023134-y665agnh 938 30 ( ( -LRB- cord-023134-y665agnh 938 31 3 3 CD cord-023134-y665agnh 938 32 ) ) -RRB- cord-023134-y665agnh 938 33 , , , cord-023134-y665agnh 938 34 retching retch VBG cord-023134-y665agnh 938 35 ( ( -LRB- cord-023134-y665agnh 938 36 2 2 CD cord-023134-y665agnh 938 37 ) ) -RRB- cord-023134-y665agnh 938 38 , , , cord-023134-y665agnh 938 39 regurgitation regurgitation NN cord-023134-y665agnh 938 40 ( ( -LRB- cord-023134-y665agnh 938 41 2 2 CD cord-023134-y665agnh 938 42 ) ) -RRB- cord-023134-y665agnh 938 43 , , , cord-023134-y665agnh 938 44 sudden sudden JJ cord-023134-y665agnh 938 45 discomfort discomfort NN cord-023134-y665agnh 938 46 ( ( -LRB- cord-023134-y665agnh 938 47 2 2 CD cord-023134-y665agnh 938 48 ) ) -RRB- cord-023134-y665agnh 938 49 , , , cord-023134-y665agnh 938 50 excessive excessive JJ cord-023134-y665agnh 938 51 surface surface NN cord-023134-y665agnh 938 52 - - HYPH cord-023134-y665agnh 938 53 licking licking NN cord-023134-y665agnh 938 54 ( ( -LRB- cord-023134-y665agnh 938 55 2 2 CD cord-023134-y665agnh 938 56 ) ) -RRB- cord-023134-y665agnh 938 57 , , , cord-023134-y665agnh 938 58 ptyalism ptyalism NNP cord-023134-y665agnh 938 59 ( ( -LRB- cord-023134-y665agnh 938 60 2 2 CD cord-023134-y665agnh 938 61 ) ) -RRB- cord-023134-y665agnh 938 62 , , , cord-023134-y665agnh 938 63 presumed presume VBN cord-023134-y665agnh 938 64 postprandial postprandial JJ cord-023134-y665agnh 938 65 pain pain NN cord-023134-y665agnh 938 66 ( ( -LRB- cord-023134-y665agnh 938 67 2 2 CD cord-023134-y665agnh 938 68 ) ) -RRB- cord-023134-y665agnh 938 69 , , , cord-023134-y665agnh 938 70 refusal refusal NN cord-023134-y665agnh 938 71 to to TO cord-023134-y665agnh 938 72 eat eat VB cord-023134-y665agnh 938 73 despite despite IN cord-023134-y665agnh 938 74 interest interest NN cord-023134-y665agnh 938 75 ( ( -LRB- cord-023134-y665agnh 938 76 2 2 CD cord-023134-y665agnh 938 77 ) ) -RRB- cord-023134-y665agnh 938 78 , , , cord-023134-y665agnh 938 79 history history NN cord-023134-y665agnh 938 80 of of IN cord-023134-y665agnh 938 81 esophageal esophageal JJ cord-023134-y665agnh 938 82 foreign foreign JJ cord-023134-y665agnh 938 83 bodies body NNS cord-023134-y665agnh 938 84 ( ( -LRB- cord-023134-y665agnh 938 85 1 1 CD cord-023134-y665agnh 938 86 ) ) -RRB- cord-023134-y665agnh 938 87 , , , cord-023134-y665agnh 938 88 halitosis halitosis NN cord-023134-y665agnh 938 89 ( ( -LRB- cord-023134-y665agnh 938 90 1 1 CD cord-023134-y665agnh 938 91 ) ) -RRB- cord-023134-y665agnh 938 92 . . . cord-023134-y665agnh 939 1 Each each DT cord-023134-y665agnh 939 2 dog dog NN cord-023134-y665agnh 939 3 showed show VBD cord-023134-y665agnh 939 4 a a DT cord-023134-y665agnh 939 5 median median NN cord-023134-y665agnh 939 6 of of IN cord-023134-y665agnh 939 7 3 3 CD cord-023134-y665agnh 939 8 ( ( -LRB- cord-023134-y665agnh 939 9 1 1 CD cord-023134-y665agnh 939 10 - - SYM cord-023134-y665agnh 939 11 4 4 CD cord-023134-y665agnh 939 12 ) ) -RRB- cord-023134-y665agnh 939 13 signs sign NNS cord-023134-y665agnh 939 14 , , , cord-023134-y665agnh 939 15 3 3 CD cord-023134-y665agnh 939 16 dogs dog NNS cord-023134-y665agnh 939 17 had have VBD cord-023134-y665agnh 939 18 additional additional JJ cord-023134-y665agnh 939 19 diarrhea diarrhea NN cord-023134-y665agnh 939 20 . . . cord-023134-y665agnh 940 1 Six six CD cord-023134-y665agnh 940 2 healthy healthy JJ cord-023134-y665agnh 940 3 Beagles beagle NNS cord-023134-y665agnh 940 4 ( ( -LRB- cord-023134-y665agnh 940 5 median median JJ cord-023134-y665agnh 940 6 BW BW NNP cord-023134-y665agnh 940 7 13.9 13.9 CD cord-023134-y665agnh 940 8 kg kg NNS cord-023134-y665agnh 940 9 , , , cord-023134-y665agnh 940 10 median median JJ cord-023134-y665agnh 940 11 age age NN cord-023134-y665agnh 940 12 1.5y 1.5y CD cord-023134-y665agnh 940 13 ) ) -RRB- cord-023134-y665agnh 940 14 with with IN cord-023134-y665agnh 940 15 unremarkable unremarkable JJ cord-023134-y665agnh 940 16 gastroduodenal gastroduodenal JJ cord-023134-y665agnh 940 17 evaluation evaluation NN cord-023134-y665agnh 940 18 served serve VBD cord-023134-y665agnh 940 19 as as IN cord-023134-y665agnh 940 20 controls control NNS cord-023134-y665agnh 940 21 ( ( -LRB- cord-023134-y665agnh 940 22 C C NNP cord-023134-y665agnh 940 23 ) ) -RRB- cord-023134-y665agnh 940 24 . . . cord-023134-y665agnh 941 1 No no DT cord-023134-y665agnh 941 2 prior prior JJ cord-023134-y665agnh 941 3 antacid antacid JJ cord-023134-y665agnh 941 4 or or CC cord-023134-y665agnh 941 5 prokinetic prokinetic JJ cord-023134-y665agnh 941 6 treatment treatment NN cord-023134-y665agnh 941 7 was be VBD cord-023134-y665agnh 941 8 allowed allow VBN cord-023134-y665agnh 941 9 . . . cord-023134-y665agnh 942 1 The the DT cord-023134-y665agnh 942 2 capsule capsule NN cord-023134-y665agnh 942 3 was be VBD cord-023134-y665agnh 942 4 endoscopically endoscopically RB cord-023134-y665agnh 942 5 placed place VBN cord-023134-y665agnh 942 6 4 4 CD cord-023134-y665agnh 942 7 cm cm NNS cord-023134-y665agnh 942 8 above above IN cord-023134-y665agnh 942 9 the the DT cord-023134-y665agnh 942 10 lower low JJR cord-023134-y665agnh 942 11 esophageal esophageal JJ cord-023134-y665agnh 942 12 sphincter sphincter NN cord-023134-y665agnh 942 13 , , , cord-023134-y665agnh 942 14 pH pH NNP cord-023134-y665agnh 942 15 data datum NNS cord-023134-y665agnh 942 16 were be VBD cord-023134-y665agnh 942 17 transmitted transmit VBN cord-023134-y665agnh 942 18 every every DT cord-023134-y665agnh 942 19 4s 4s CD cord-023134-y665agnh 942 20 to to IN cord-023134-y665agnh 942 21 a a DT cord-023134-y665agnh 942 22 receiver receiver NN cord-023134-y665agnh 942 23 attached attach VBN cord-023134-y665agnh 942 24 to to IN cord-023134-y665agnh 942 25 the the DT cord-023134-y665agnh 942 26 dog dog NN cord-023134-y665agnh 942 27 's 's POS cord-023134-y665agnh 942 28 collar collar NN cord-023134-y665agnh 942 29 . . . cord-023134-y665agnh 943 1 Owners owner NNS cord-023134-y665agnh 943 2 were be VBD cord-023134-y665agnh 943 3 instructed instruct VBN cord-023134-y665agnh 943 4 to to TO cord-023134-y665agnh 943 5 press press VB cord-023134-y665agnh 943 6 the the DT cord-023134-y665agnh 943 7 individually individually RB cord-023134-y665agnh 943 8 predefined predefined JJ cord-023134-y665agnh 943 9 symptom symptom NN cord-023134-y665agnh 943 10 - - HYPH cord-023134-y665agnh 943 11 buttons button NNS cord-023134-y665agnh 943 12 on on IN cord-023134-y665agnh 943 13 the the DT cord-023134-y665agnh 943 14 receiver receiver NN cord-023134-y665agnh 943 15 whenever whenever WRB cord-023134-y665agnh 943 16 indicated indicate VBD cord-023134-y665agnh 943 17 , , , cord-023134-y665agnh 943 18 and and CC cord-023134-y665agnh 943 19 not not RB cord-023134-y665agnh 943 20 to to TO cord-023134-y665agnh 943 21 change change VB cord-023134-y665agnh 943 22 the the DT cord-023134-y665agnh 943 23 daily daily JJ cord-023134-y665agnh 943 24 routine routine NN cord-023134-y665agnh 943 25 . . . cord-023134-y665agnh 944 1 Data datum NNS cord-023134-y665agnh 944 2 were be VBD cord-023134-y665agnh 944 3 analysed analyse VBN cord-023134-y665agnh 944 4 using use VBG cord-023134-y665agnh 944 5 the the DT cord-023134-y665agnh 944 6 RapidpH rapidph NN cord-023134-y665agnh 945 1 ® ® LS cord-023134-y665agnh 945 2 software software NN cord-023134-y665agnh 945 3 , , , cord-023134-y665agnh 945 4 reflux reflux NN cord-023134-y665agnh 945 5 was be VBD cord-023134-y665agnh 945 6 defined define VBN cord-023134-y665agnh 945 7 as as IN cord-023134-y665agnh 945 8 a a DT cord-023134-y665agnh 945 9 single single JJ cord-023134-y665agnh 945 10 pH ph NN cord-023134-y665agnh 945 11 - - NN cord-023134-y665agnh 945 12 measurement measurement NN cord-023134-y665agnh 945 13 < < XX cord-023134-y665agnh 945 14 4 4 CD cord-023134-y665agnh 945 15 . . . cord-023134-y665agnh 946 1 Results result NNS cord-023134-y665agnh 946 2 between between IN cord-023134-y665agnh 946 3 groups group NNS cord-023134-y665agnh 946 4 were be VBD cord-023134-y665agnh 946 5 compared compare VBN cord-023134-y665agnh 946 6 using use VBG cord-023134-y665agnh 946 7 non non JJ cord-023134-y665agnh 946 8 - - JJ cord-023134-y665agnh 946 9 parametric parametric JJ cord-023134-y665agnh 946 10 tests test NNS cord-023134-y665agnh 946 11 . . . cord-023134-y665agnh 947 1 The the DT cord-023134-y665agnh 947 2 median median JJ cord-023134-y665agnh 947 3 pH ph NN cord-023134-y665agnh 947 4 - - HYPH cord-023134-y665agnh 947 5 monitoring monitor VBG cord-023134-y665agnh 947 6 period period NN cord-023134-y665agnh 947 7 ( ( -LRB- cord-023134-y665agnh 947 8 COD COD NNP cord-023134-y665agnh 947 9 / / SYM cord-023134-y665agnh 947 10 C C NNP cord-023134-y665agnh 947 11 ) ) -RRB- cord-023134-y665agnh 947 12 was be VBD cord-023134-y665agnh 947 13 47.49/ 47.49/ CD cord-023134-y665agnh 947 14 43.17h 43.17h NNP cord-023134-y665agnh 947 15 . . . cord-023134-y665agnh 948 1 The the DT cord-023134-y665agnh 948 2 following follow VBG cord-023134-y665agnh 948 3 parameters parameter NNS cord-023134-y665agnh 948 4 ( ( -LRB- cord-023134-y665agnh 948 5 median median NN cord-023134-y665agnh 948 6 , , , cord-023134-y665agnh 948 7 range range NN cord-023134-y665agnh 948 8 for for IN cord-023134-y665agnh 948 9 COD COD NNP cord-023134-y665agnh 948 10 / / SYM cord-023134-y665agnh 948 11 C c NN cord-023134-y665agnh 948 12 ) ) -RRB- cord-023134-y665agnh 948 13 were be VBD cord-023134-y665agnh 948 14 evaluated evaluate VBN cord-023134-y665agnh 948 15 : : : cord-023134-y665agnh 948 16 Number number NN cord-023134-y665agnh 948 17 of of IN cord-023134-y665agnh 948 18 refluxes refluxes NNP cord-023134-y665agnh 948 19 : : : cord-023134-y665agnh 948 20 12 12 CD cord-023134-y665agnh 948 21 ( ( -LRB- cord-023134-y665agnh 948 22 1 1 CD cord-023134-y665agnh 948 23 - - HYPH cord-023134-y665agnh 948 24 86)/13.5 86)/13.5 CD cord-023134-y665agnh 948 25 ( ( -LRB- cord-023134-y665agnh 948 26 1 1 CD cord-023134-y665agnh 948 27 - - SYM cord-023134-y665agnh 948 28 65 65 CD cord-023134-y665agnh 948 29 ) ) -RRB- cord-023134-y665agnh 948 30 , , , cord-023134-y665agnh 948 31 number number NN cord-023134-y665agnh 948 32 of of IN cord-023134-y665agnh 948 33 longest long JJS cord-023134-y665agnh 948 34 ( ( -LRB- cord-023134-y665agnh 948 35 > > NFP cord-023134-y665agnh 948 36 5min 5min CD cord-023134-y665agnh 948 37 ) ) -RRB- cord-023134-y665agnh 948 38 reflux reflux NN cord-023134-y665agnh 948 39 : : : cord-023134-y665agnh 948 40 1 1 CD cord-023134-y665agnh 948 41 ( ( -LRB- cord-023134-y665agnh 948 42 0 0 CD cord-023134-y665agnh 948 43 - - SYM cord-023134-y665agnh 948 44 14)/1 14)/1 CD cord-023134-y665agnh 948 45 ( ( -LRB- cord-023134-y665agnh 948 46 0 0 CD cord-023134-y665agnh 948 47 - - SYM cord-023134-y665agnh 948 48 4 4 CD cord-023134-y665agnh 948 49 ) ) -RRB- cord-023134-y665agnh 948 50 , , , cord-023134-y665agnh 948 51 duration duration NN cord-023134-y665agnh 948 52 of of IN cord-023134-y665agnh 948 53 longest long JJS cord-023134-y665agnh 948 54 reflux reflux NN cord-023134-y665agnh 948 55 ( ( -LRB- cord-023134-y665agnh 948 56 min min NN cord-023134-y665agnh 948 57 ) ) -RRB- cord-023134-y665agnh 948 58 : : : cord-023134-y665agnh 948 59 7 7 CD cord-023134-y665agnh 948 60 ( ( -LRB- cord-023134-y665agnh 948 61 1 1 CD cord-023134-y665agnh 948 62 - - SYM cord-023134-y665agnh 948 63 18)/6.5 18)/6.5 CD cord-023134-y665agnh 948 64 , , , cord-023134-y665agnh 948 65 and and CC cord-023134-y665agnh 948 66 fraction fraction NN cord-023134-y665agnh 948 67 time time NN cord-023134-y665agnh 949 1 pH pH NNP cord-023134-y665agnh 950 1 < < XX cord-023134-y665agnh 950 2 4 4 CD cord-023134-y665agnh 950 3 ( ( -LRB- cord-023134-y665agnh 950 4 % % NN cord-023134-y665agnh 950 5 ) ) -RRB- cord-023134-y665agnh 950 6 : : : cord-023134-y665agnh 950 7 0.5 0.5 CD cord-023134-y665agnh 950 8 ( ( -LRB- cord-023134-y665agnh 950 9 0.01 0.01 CD cord-023134-y665agnh 950 10 - - SYM cord-023134-y665agnh 950 11 5.6)/0.5 5.6)/0.5 CD cord-023134-y665agnh 950 12 ( ( -LRB- cord-023134-y665agnh 950 13 0 0 CD cord-023134-y665agnh 950 14 - - SYM cord-023134-y665agnh 950 15 3.2 3.2 CD cord-023134-y665agnh 950 16 ) ) -RRB- cord-023134-y665agnh 950 17 . . . cord-023134-y665agnh 951 1 There there EX cord-023134-y665agnh 951 2 were be VBD cord-023134-y665agnh 951 3 no no DT cord-023134-y665agnh 951 4 differences difference NNS cord-023134-y665agnh 951 5 between between IN cord-023134-y665agnh 951 6 groups group NNS cord-023134-y665agnh 951 7 . . . cord-023134-y665agnh 952 1 The the DT cord-023134-y665agnh 952 2 median median JJ cord-023134-y665agnh 952 3 number number NN cord-023134-y665agnh 952 4 of of IN cord-023134-y665agnh 952 5 button button NN cord-023134-y665agnh 952 6 pushes push NNS cord-023134-y665agnh 952 7 was be VBD cord-023134-y665agnh 952 8 6 6 CD cord-023134-y665agnh 952 9 ( ( -LRB- cord-023134-y665agnh 952 10 0 0 CD cord-023134-y665agnh 952 11 - - SYM cord-023134-y665agnh 952 12 35 35 CD cord-023134-y665agnh 952 13 ) ) -RRB- cord-023134-y665agnh 952 14 , , , cord-023134-y665agnh 952 15 3 3 CD cord-023134-y665agnh 952 16 dogs dog NNS cord-023134-y665agnh 952 17 had have VBD cord-023134-y665agnh 952 18 reflux reflux NN cord-023134-y665agnh 952 19 - - HYPH cord-023134-y665agnh 952 20 positive positive JJ cord-023134-y665agnh 952 21 pushes push NNS cord-023134-y665agnh 952 22 ( ( -LRB- cord-023134-y665agnh 952 23 2.8 2.8 CD cord-023134-y665agnh 952 24 , , , cord-023134-y665agnh 952 25 11 11 CD cord-023134-y665agnh 952 26 , , , cord-023134-y665agnh 952 27 and and CC cord-023134-y665agnh 952 28 17.6 17.6 CD cord-023134-y665agnh 952 29 % % NN cord-023134-y665agnh 952 30 of of IN cord-023134-y665agnh 952 31 pushes push NNS cord-023134-y665agnh 952 32 ) ) -RRB- cord-023134-y665agnh 952 33 . . . cord-023134-y665agnh 953 1 Mild mild JJ cord-023134-y665agnh 953 2 distal distal JJ cord-023134-y665agnh 953 3 esophagitis esophagitis NN cord-023134-y665agnh 953 4 was be VBD cord-023134-y665agnh 953 5 noted note VBN cord-023134-y665agnh 953 6 in in IN cord-023134-y665agnh 953 7 1 1 CD cord-023134-y665agnh 953 8 dog dog NN cord-023134-y665agnh 953 9 . . . cord-023134-y665agnh 954 1 Final final JJ cord-023134-y665agnh 954 2 diagnoses diagnosis NNS cord-023134-y665agnh 954 3 were be VBD cord-023134-y665agnh 954 4 : : : cord-023134-y665agnh 954 5 food food NN cord-023134-y665agnh 954 6 - - HYPH cord-023134-y665agnh 954 7 responsive responsive JJ cord-023134-y665agnh 954 8 IBD IBD NNP cord-023134-y665agnh 954 9 ( ( -LRB- cord-023134-y665agnh 954 10 6 6 CD cord-023134-y665agnh 954 11 ) ) -RRB- cord-023134-y665agnh 954 12 , , , cord-023134-y665agnh 954 13 steroid steroid NN cord-023134-y665agnh 954 14 - - HYPH cord-023134-y665agnh 954 15 responsive responsive JJ cord-023134-y665agnh 954 16 IBD IBD NNP cord-023134-y665agnh 954 17 ( ( -LRB- cord-023134-y665agnh 954 18 2 2 CD cord-023134-y665agnh 954 19 ) ) -RRB- cord-023134-y665agnh 954 20 , , , cord-023134-y665agnh 954 21 allergic allergic JJ cord-023134-y665agnh 954 22 skin skin NN cord-023134-y665agnh 954 23 disease disease NN cord-023134-y665agnh 954 24 ( ( -LRB- cord-023134-y665agnh 954 25 2 2 CD cord-023134-y665agnh 954 26 ) ) -RRB- cord-023134-y665agnh 954 27 , , , cord-023134-y665agnh 954 28 chronic chronic JJ cord-023134-y665agnh 954 29 laryngotracheobronchitis laryngotracheobronchitis NNP cord-023134-y665agnh 954 30 ( ( -LRB- cord-023134-y665agnh 954 31 2 2 CD cord-023134-y665agnh 954 32 ) ) -RRB- cord-023134-y665agnh 954 33 , , , cord-023134-y665agnh 954 34 muscular muscular JJ cord-023134-y665agnh 954 35 dystrophy dystrophy NN cord-023134-y665agnh 954 36 ( ( -LRB- cord-023134-y665agnh 954 37 1 1 CD cord-023134-y665agnh 954 38 ) ) -RRB- cord-023134-y665agnh 954 39 .Dogs .Dogs . cord-023134-y665agnh 955 1 presenting present VBG cord-023134-y665agnh 955 2 with with IN cord-023134-y665agnh 955 3 historical historical JJ cord-023134-y665agnh 955 4 and and CC cord-023134-y665agnh 955 5 clinical clinical JJ cord-023134-y665agnh 955 6 signs sign NNS cord-023134-y665agnh 955 7 interpreted interpret VBN cord-023134-y665agnh 955 8 as as IN cord-023134-y665agnh 955 9 GER GER NNP cord-023134-y665agnh 955 10 may may MD cord-023134-y665agnh 955 11 not not RB cord-023134-y665agnh 955 12 have have VB cord-023134-y665agnh 955 13 relevant relevant JJ cord-023134-y665agnh 955 14 reflux reflux NN cord-023134-y665agnh 955 15 episodes episode NNS cord-023134-y665agnh 955 16 . . . cord-023134-y665agnh 956 1 Considering consider VBG cord-023134-y665agnh 956 2 normal normal JJ cord-023134-y665agnh 956 3 values value NNS cord-023134-y665agnh 956 4 established establish VBN cord-023134-y665agnh 956 5 in in IN cord-023134-y665agnh 956 6 humans human NNS cord-023134-y665agnh 956 7 , , , cord-023134-y665agnh 956 8 none none NN cord-023134-y665agnh 956 9 of of IN cord-023134-y665agnh 956 10 the the DT cord-023134-y665agnh 956 11 dogs dog NNS cord-023134-y665agnh 956 12 would would MD cord-023134-y665agnh 956 13 have have VB cord-023134-y665agnh 956 14 been be VBN cord-023134-y665agnh 956 15 classified classify VBN cord-023134-y665agnh 956 16 as as IN cord-023134-y665agnh 956 17 abnormal abnormal JJ cord-023134-y665agnh 956 18 . . . cord-023134-y665agnh 957 1 The the DT cord-023134-y665agnh 957 2 aim aim NN cord-023134-y665agnh 957 3 of of IN cord-023134-y665agnh 957 4 the the DT cord-023134-y665agnh 957 5 present present JJ cord-023134-y665agnh 957 6 study study NN cord-023134-y665agnh 957 7 was be VBD cord-023134-y665agnh 957 8 to to TO cord-023134-y665agnh 957 9 evaluate evaluate VB cord-023134-y665agnh 957 10 the the DT cord-023134-y665agnh 957 11 changes change NNS cord-023134-y665agnh 957 12 of of IN cord-023134-y665agnh 957 13 some some DT cord-023134-y665agnh 957 14 biochemical biochemical JJ cord-023134-y665agnh 957 15 and and CC cord-023134-y665agnh 957 16 ultrasonographic ultrasonographic JJ cord-023134-y665agnh 957 17 ( ( -LRB- cord-023134-y665agnh 957 18 US US NNP cord-023134-y665agnh 957 19 ) ) -RRB- cord-023134-y665agnh 957 20 parameters parameter VBZ cord-023134-y665agnh 957 21 in in IN cord-023134-y665agnh 957 22 a a DT cord-023134-y665agnh 957 23 group group NN cord-023134-y665agnh 957 24 of of IN cord-023134-y665agnh 957 25 dogs dog NNS cord-023134-y665agnh 957 26 with with IN cord-023134-y665agnh 957 27 naturally naturally RB cord-023134-y665agnh 957 28 occurring occur VBG cord-023134-y665agnh 957 29 acute acute JJ cord-023134-y665agnh 957 30 pancreatitis pancreatitis NN cord-023134-y665agnh 957 31 ( ( -LRB- cord-023134-y665agnh 957 32 AP AP NNP cord-023134-y665agnh 957 33 ) ) -RRB- cord-023134-y665agnh 957 34 during during IN cord-023134-y665agnh 957 35 the the DT cord-023134-y665agnh 957 36 therapeutic therapeutic JJ cord-023134-y665agnh 957 37 follow follow NN cord-023134-y665agnh 957 38 - - HYPH cord-023134-y665agnh 957 39 up up NN cord-023134-y665agnh 957 40 . . . cord-023134-y665agnh 958 1 Dogs dog NNS cord-023134-y665agnh 958 2 with with IN cord-023134-y665agnh 958 3 clinical clinical JJ cord-023134-y665agnh 958 4 signs sign NNS cord-023134-y665agnh 958 5 and and CC cord-023134-y665agnh 958 6 abdominal abdominal JJ cord-023134-y665agnh 958 7 US US NNP cord-023134-y665agnh 958 8 findings finding NNS cord-023134-y665agnh 958 9 suggestive suggestive JJ cord-023134-y665agnh 958 10 of of IN cord-023134-y665agnh 958 11 AP AP NNP cord-023134-y665agnh 958 12 associated associate VBN cord-023134-y665agnh 958 13 with with IN cord-023134-y665agnh 958 14 increased increase VBN cord-023134-y665agnh 958 15 serum serum NN cord-023134-y665agnh 958 16 canine canine JJ cord-023134-y665agnh 958 17 pancreatic pancreatic NN cord-023134-y665agnh 958 18 lipase lipase NN cord-023134-y665agnh 958 19 ( ( -LRB- cord-023134-y665agnh 958 20 cPL cPL NNS cord-023134-y665agnh 958 21 ) ) -RRB- cord-023134-y665agnh 958 22 activity activity NN cord-023134-y665agnh 958 23 were be VBD cord-023134-y665agnh 958 24 included include VBN cord-023134-y665agnh 958 25 into into IN cord-023134-y665agnh 958 26 the the DT cord-023134-y665agnh 958 27 study study NN cord-023134-y665agnh 958 28 . . . cord-023134-y665agnh 959 1 In in IN cord-023134-y665agnh 959 2 these these DT cord-023134-y665agnh 959 3 dogs dog NNS cord-023134-y665agnh 959 4 , , , cord-023134-y665agnh 959 5 the the DT cord-023134-y665agnh 959 6 serum serum NN cord-023134-y665agnh 959 7 concentration concentration NN cord-023134-y665agnh 959 8 of of IN cord-023134-y665agnh 959 9 C C NNP cord-023134-y665agnh 959 10 - - HYPH cord-023134-y665agnh 959 11 reactive reactive JJ cord-023134-y665agnh 959 12 protein protein NN cord-023134-y665agnh 959 13 ( ( -LRB- cord-023134-y665agnh 959 14 CRP CRP NNP cord-023134-y665agnh 959 15 ) ) -RRB- cord-023134-y665agnh 959 16 , , , cord-023134-y665agnh 959 17 amylase amylase NN cord-023134-y665agnh 959 18 and and CC cord-023134-y665agnh 959 19 lipase lipase NN cord-023134-y665agnh 959 20 were be VBD cord-023134-y665agnh 959 21 also also RB cord-023134-y665agnh 959 22 measured measure VBN cord-023134-y665agnh 959 23 . . . cord-023134-y665agnh 960 1 Severity severity NN cord-023134-y665agnh 960 2 indexes index NNS cord-023134-y665agnh 960 3 were be VBD cord-023134-y665agnh 960 4 established establish VBN cord-023134-y665agnh 960 5 to to IN cord-023134-y665agnh 960 6 semi semi VB cord-023134-y665agnh 960 7 - - JJ cord-023134-y665agnh 960 8 quantitatively quantitatively RB cord-023134-y665agnh 960 9 evaluate evaluate VB cord-023134-y665agnh 960 10 the the DT cord-023134-y665agnh 960 11 severity severity NN cord-023134-y665agnh 960 12 of of IN cord-023134-y665agnh 960 13 clinical clinical JJ cord-023134-y665agnh 960 14 and and CC cord-023134-y665agnh 960 15 US US NNP cord-023134-y665agnh 960 16 findings finding NNS cord-023134-y665agnh 960 17 . . . cord-023134-y665agnh 961 1 In in IN cord-023134-y665agnh 961 2 particular particular JJ cord-023134-y665agnh 961 3 , , , cord-023134-y665agnh 961 4 a a DT cord-023134-y665agnh 961 5 clinical clinical JJ cord-023134-y665agnh 961 6 score score NN cord-023134-y665agnh 961 7 ( ( -LRB- cord-023134-y665agnh 961 8 0 0 CD cord-023134-y665agnh 961 9 - - SYM cord-023134-y665agnh 961 10 3 3 CD cord-023134-y665agnh 961 11 ) ) -RRB- cord-023134-y665agnh 961 12 for for IN cord-023134-y665agnh 961 13 each each DT cord-023134-y665agnh 961 14 of of IN cord-023134-y665agnh 961 15 the the DT cord-023134-y665agnh 961 16 following follow VBG cord-023134-y665agnh 961 17 clinical clinical JJ cord-023134-y665agnh 961 18 parameters parameter NNS cord-023134-y665agnh 961 19 was be VBD cord-023134-y665agnh 961 20 given give VBN cord-023134-y665agnh 961 21 : : : cord-023134-y665agnh 961 22 presence presence NN cord-023134-y665agnh 961 23 and and CC cord-023134-y665agnh 961 24 frequency frequency NN cord-023134-y665agnh 961 25 of of IN cord-023134-y665agnh 961 26 vomiting vomiting NN cord-023134-y665agnh 961 27 , , , cord-023134-y665agnh 961 28 appetite appetite NN cord-023134-y665agnh 961 29 and and CC cord-023134-y665agnh 961 30 general general JJ cord-023134-y665agnh 961 31 condition condition NN cord-023134-y665agnh 961 32 ; ; : cord-023134-y665agnh 961 33 an an DT cord-023134-y665agnh 961 34 US US NNP cord-023134-y665agnh 961 35 score score NN cord-023134-y665agnh 961 36 ( ( -LRB- cord-023134-y665agnh 961 37 0 0 NFP cord-023134-y665agnh 962 1 = = NFP cord-023134-y665agnh 962 2 normal normal JJ cord-023134-y665agnh 962 3 , , , cord-023134-y665agnh 962 4 1 1 CD cord-023134-y665agnh 962 5 = = SYM cord-023134-y665agnh 962 6 abnormal abnormal JJ cord-023134-y665agnh 962 7 ) ) -RRB- cord-023134-y665agnh 962 8 was be VBD cord-023134-y665agnh 962 9 assigned assign VBN cord-023134-y665agnh 962 10 per per IN cord-023134-y665agnh 962 11 each each DT cord-023134-y665agnh 962 12 of of IN cord-023134-y665agnh 962 13 the the DT cord-023134-y665agnh 962 14 following follow VBG cord-023134-y665agnh 962 15 parameters parameter NNS cord-023134-y665agnh 962 16 : : : cord-023134-y665agnh 962 17 pancreas pancrea NNS cord-023134-y665agnh 962 18 ( ( -LRB- cord-023134-y665agnh 962 19 echogenicity echogenicity NN cord-023134-y665agnh 962 20 , , , cord-023134-y665agnh 962 21 volume volume NN cord-023134-y665agnh 962 22 , , , cord-023134-y665agnh 962 23 echotexture echotexture NN cord-023134-y665agnh 962 24 and and CC cord-023134-y665agnh 962 25 echogenicity echogenicity NN cord-023134-y665agnh 962 26 of of IN cord-023134-y665agnh 962 27 the the DT cord-023134-y665agnh 962 28 mesentery mesentery NN cord-023134-y665agnh 962 29 ) ) -RRB- cord-023134-y665agnh 962 30 , , , cord-023134-y665agnh 962 31 gastrointestinal gastrointestinal JJ cord-023134-y665agnh 962 32 tract tract NN cord-023134-y665agnh 962 33 , , , cord-023134-y665agnh 962 34 biliary biliary JJ cord-023134-y665agnh 962 35 ducts duct NNS cord-023134-y665agnh 962 36 , , , cord-023134-y665agnh 962 37 lymph lymph NN cord-023134-y665agnh 962 38 nodes node NNS cord-023134-y665agnh 962 39 and and CC cord-023134-y665agnh 962 40 abdominal abdominal JJ cord-023134-y665agnh 962 41 effusion effusion NN cord-023134-y665agnh 962 42 ( ( -LRB- cord-023134-y665agnh 962 43 total total JJ cord-023134-y665agnh 962 44 score score NN cord-023134-y665agnh 962 45 0 0 CD cord-023134-y665agnh 962 46 - - SYM cord-023134-y665agnh 962 47 14 14 CD cord-023134-y665agnh 962 48 ) ) -RRB- cord-023134-y665agnh 962 49 . . . cord-023134-y665agnh 963 1 All all DT cord-023134-y665agnh 963 2 dogs dog NNS cord-023134-y665agnh 963 3 were be VBD cord-023134-y665agnh 963 4 treated treat VBN cord-023134-y665agnh 963 5 with with IN cord-023134-y665agnh 963 6 fluid fluid JJ cord-023134-y665agnh 963 7 therapy therapy NN cord-023134-y665agnh 963 8 , , , cord-023134-y665agnh 963 9 ampicillin ampicillin NN cord-023134-y665agnh 963 10 - - HYPH cord-023134-y665agnh 963 11 sulbactam sulbactam NNS cord-023134-y665agnh 963 12 , , , cord-023134-y665agnh 963 13 15mg 15mg RB cord-023134-y665agnh 963 14 / / SYM cord-023134-y665agnh 963 15 kg kg NN cord-023134-y665agnh 963 16 IV IV NNP cord-023134-y665agnh 963 17 q8h q8h NNP cord-023134-y665agnh 963 18 , , , cord-023134-y665agnh 963 19 buprenorphine buprenorphine NN cord-023134-y665agnh 963 20 , , , cord-023134-y665agnh 963 21 0.01mg 0.01mg CD cord-023134-y665agnh 963 22 / / SYM cord-023134-y665agnh 963 23 kg kg NNP cord-023134-y665agnh 963 24 q8h q8h NNP cord-023134-y665agnh 963 25 , , , cord-023134-y665agnh 963 26 and and CC cord-023134-y665agnh 963 27 , , , cord-023134-y665agnh 963 28 if if IN cord-023134-y665agnh 963 29 needed need VBN cord-023134-y665agnh 963 30 , , , cord-023134-y665agnh 963 31 maropitant maropitant NNP cord-023134-y665agnh 963 32 1mg/ 1mg/ CD cord-023134-y665agnh 964 1 kg kg NNP cord-023134-y665agnh 965 1 SC SC NNP cord-023134-y665agnh 965 2 q24h q24h CD cord-023134-y665agnh 965 3 . . . cord-023134-y665agnh 966 1 The the DT cord-023134-y665agnh 966 2 two two CD cord-023134-y665agnh 966 3 severity severity NN cord-023134-y665agnh 966 4 scores score NNS cord-023134-y665agnh 966 5 , , , cord-023134-y665agnh 966 6 serum serum NN cord-023134-y665agnh 966 7 CRP crp NN cord-023134-y665agnh 966 8 , , , cord-023134-y665agnh 966 9 amylase amylase NN cord-023134-y665agnh 966 10 and and CC cord-023134-y665agnh 966 11 lipase lipase NN cord-023134-y665agnh 966 12 concentrations concentration NNS cord-023134-y665agnh 966 13 were be VBD cord-023134-y665agnh 966 14 measured measure VBN cord-023134-y665agnh 966 15 at at IN cord-023134-y665agnh 966 16 diagnosis diagnosis NN cord-023134-y665agnh 966 17 ( ( -LRB- cord-023134-y665agnh 966 18 T0 T0 NNP cord-023134-y665agnh 966 19 ) ) -RRB- cord-023134-y665agnh 966 20 and and CC cord-023134-y665agnh 966 21 after after IN cord-023134-y665agnh 966 22 1 1 CD cord-023134-y665agnh 966 23 ( ( -LRB- cord-023134-y665agnh 966 24 T1 T1 NNP cord-023134-y665agnh 966 25 ) ) -RRB- cord-023134-y665agnh 966 26 , , , cord-023134-y665agnh 966 27 3 3 CD cord-023134-y665agnh 966 28 ( ( -LRB- cord-023134-y665agnh 966 29 T3 T3 NNP cord-023134-y665agnh 966 30 ) ) -RRB- cord-023134-y665agnh 966 31 , , , cord-023134-y665agnh 966 32 and and CC cord-023134-y665agnh 966 33 5 5 LS cord-023134-y665agnh 966 34 ( ( -LRB- cord-023134-y665agnh 966 35 T5 T5 NNP cord-023134-y665agnh 966 36 ) ) -RRB- cord-023134-y665agnh 966 37 days day NNS cord-023134-y665agnh 966 38 , , , cord-023134-y665agnh 966 39 and and CC cord-023134-y665agnh 966 40 at at IN cord-023134-y665agnh 966 41 discharge discharge NN cord-023134-y665agnh 966 42 ( ( -LRB- cord-023134-y665agnh 966 43 Td Td NNP cord-023134-y665agnh 966 44 ) ) -RRB- cord-023134-y665agnh 966 45 and and CC cord-023134-y665agnh 966 46 1 1 CD cord-023134-y665agnh 966 47 week week NN cord-023134-y665agnh 966 48 after after IN cord-023134-y665agnh 966 49 discharge discharge NN cord-023134-y665agnh 966 50 ( ( -LRB- cord-023134-y665agnh 966 51 Td1).Nine td1).nine JJ cord-023134-y665agnh 966 52 client client NN cord-023134-y665agnh 966 53 - - HYPH cord-023134-y665agnh 966 54 owned own VBN cord-023134-y665agnh 966 55 dogs dog NNS cord-023134-y665agnh 966 56 were be VBD cord-023134-y665agnh 966 57 included include VBN cord-023134-y665agnh 966 58 with with IN cord-023134-y665agnh 966 59 a a DT cord-023134-y665agnh 966 60 median median NN cord-023134-y665agnh 966 61 ( ( -LRB- cord-023134-y665agnh 966 62 range range NN cord-023134-y665agnh 966 63 ) ) -RRB- cord-023134-y665agnh 966 64 age age NN cord-023134-y665agnh 966 65 of of IN cord-023134-y665agnh 966 66 10 10 CD cord-023134-y665agnh 966 67 years year NNS cord-023134-y665agnh 966 68 ( ( -LRB- cord-023134-y665agnh 966 69 8 8 CD cord-023134-y665agnh 966 70 - - SYM cord-023134-y665agnh 966 71 14 14 CD cord-023134-y665agnh 966 72 years year NNS cord-023134-y665agnh 966 73 ) ) -RRB- cord-023134-y665agnh 966 74 . . . cord-023134-y665agnh 967 1 Median median JJ cord-023134-y665agnh 967 2 ( ( -LRB- cord-023134-y665agnh 967 3 range range NN cord-023134-y665agnh 967 4 ) ) -RRB- cord-023134-y665agnh 967 5 clinical clinical JJ cord-023134-y665agnh 967 6 and and CC cord-023134-y665agnh 967 7 US US NNP cord-023134-y665agnh 967 8 scores score NNS cord-023134-y665agnh 967 9 were be VBD cord-023134-y665agnh 967 10 8 8 CD cord-023134-y665agnh 967 11 ( ( -LRB- cord-023134-y665agnh 967 12 6 6 CD cord-023134-y665agnh 967 13 - - SYM cord-023134-y665agnh 967 14 9 9 CD cord-023134-y665agnh 967 15 ) ) -RRB- cord-023134-y665agnh 967 16 and and CC cord-023134-y665agnh 967 17 8.5 8.5 CD cord-023134-y665agnh 967 18 ( ( -LRB- cord-023134-y665agnh 967 19 3 3 CD cord-023134-y665agnh 967 20 - - SYM cord-023134-y665agnh 967 21 13 13 CD cord-023134-y665agnh 967 22 ) ) -RRB- cord-023134-y665agnh 967 23 , , , cord-023134-y665agnh 967 24 respectively respectively RB cord-023134-y665agnh 967 25 , , , cord-023134-y665agnh 967 26 at at IN cord-023134-y665agnh 967 27 T0 T0 NNP cord-023134-y665agnh 967 28 , , , cord-023134-y665agnh 967 29 and and CC cord-023134-y665agnh 967 30 0 0 NFP cord-023134-y665agnh 967 31 ( ( -LRB- cord-023134-y665agnh 967 32 0 0 CD cord-023134-y665agnh 967 33 - - SYM cord-023134-y665agnh 967 34 1 1 CD cord-023134-y665agnh 967 35 ) ) -RRB- cord-023134-y665agnh 967 36 and and CC cord-023134-y665agnh 967 37 1 1 CD cord-023134-y665agnh 967 38 ( ( -LRB- cord-023134-y665agnh 967 39 0 0 CD cord-023134-y665agnh 967 40 - - SYM cord-023134-y665agnh 967 41 3 3 CD cord-023134-y665agnh 967 42 ) ) -RRB- cord-023134-y665agnh 967 43 , , , cord-023134-y665agnh 967 44 respectively respectively RB cord-023134-y665agnh 967 45 , , , cord-023134-y665agnh 967 46 at at IN cord-023134-y665agnh 967 47 Td1 td1 CD cord-023134-y665agnh 967 48 . . . cord-023134-y665agnh 968 1 A a DT cord-023134-y665agnh 968 2 significant significant JJ cord-023134-y665agnh 968 3 , , , cord-023134-y665agnh 968 4 positive positive JJ cord-023134-y665agnh 968 5 correlation correlation NN cord-023134-y665agnh 968 6 was be VBD cord-023134-y665agnh 968 7 found find VBN cord-023134-y665agnh 968 8 between between IN cord-023134-y665agnh 968 9 the the DT cord-023134-y665agnh 968 10 clinical clinical JJ cord-023134-y665agnh 968 11 and and CC cord-023134-y665agnh 968 12 US US NNP cord-023134-y665agnh 968 13 score score NN cord-023134-y665agnh 968 14 ( ( -LRB- cord-023134-y665agnh 968 15 p<0.001 p<0.001 NNS cord-023134-y665agnh 968 16 , , , cord-023134-y665agnh 968 17 r=0.68 r=0.68 NNP cord-023134-y665agnh 968 18 ) ) -RRB- cord-023134-y665agnh 968 19 . . . cord-023134-y665agnh 969 1 The the DT cord-023134-y665agnh 969 2 median median NN cord-023134-y665agnh 969 3 ( ( -LRB- cord-023134-y665agnh 969 4 range range NN cord-023134-y665agnh 969 5 ) ) -RRB- cord-023134-y665agnh 969 6 serum serum NN cord-023134-y665agnh 969 7 concentration concentration NN cord-023134-y665agnh 969 8 of of IN cord-023134-y665agnh 969 9 CRP CRP NNP cord-023134-y665agnh 969 10 ( ( -LRB- cord-023134-y665agnh 969 11 mg mg NNP cord-023134-y665agnh 969 12 / / SYM cord-023134-y665agnh 969 13 dl dl NNP cord-023134-y665agnh 969 14 ) ) -RRB- cord-023134-y665agnh 969 15 , , , cord-023134-y665agnh 969 16 amylase amylase NN cord-023134-y665agnh 969 17 ( ( -LRB- cord-023134-y665agnh 969 18 U U NNP cord-023134-y665agnh 969 19 / / SYM cord-023134-y665agnh 969 20 L L NNP cord-023134-y665agnh 969 21 ) ) -RRB- cord-023134-y665agnh 969 22 and and CC cord-023134-y665agnh 969 23 lipase lipase NN cord-023134-y665agnh 969 24 ( ( -LRB- cord-023134-y665agnh 969 25 U U NNP cord-023134-y665agnh 969 26 / / SYM cord-023134-y665agnh 969 27 L L NNP cord-023134-y665agnh 969 28 ) ) -RRB- cord-023134-y665agnh 969 29 was be VBD cord-023134-y665agnh 969 30 9.46 9.46 CD cord-023134-y665agnh 969 31 ( ( -LRB- cord-023134-y665agnh 969 32 3.36 3.36 CD cord-023134-y665agnh 969 33 - - SYM cord-023134-y665agnh 969 34 30.4 30.4 CD cord-023134-y665agnh 969 35 ) ) -RRB- cord-023134-y665agnh 969 36 , , , cord-023134-y665agnh 969 37 2,995 2,995 CD cord-023134-y665agnh 969 38 ( ( -LRB- cord-023134-y665agnh 969 39 776 776 CD cord-023134-y665agnh 969 40 - - HYPH cord-023134-y665agnh 969 41 6,458 6,458 CD cord-023134-y665agnh 969 42 ) ) -RRB- cord-023134-y665agnh 969 43 and and CC cord-023134-y665agnh 969 44 889 889 CD cord-023134-y665agnh 969 45 270 270 CD cord-023134-y665agnh 969 46 ) ) -RRB- cord-023134-y665agnh 969 47 , , , cord-023134-y665agnh 969 48 respectively respectively RB cord-023134-y665agnh 969 49 , , , cord-023134-y665agnh 969 50 at at IN cord-023134-y665agnh 969 51 T0 T0 NNP cord-023134-y665agnh 969 52 , , , cord-023134-y665agnh 969 53 and and CC cord-023134-y665agnh 969 54 0.64 0.64 CD cord-023134-y665agnh 969 55 ( ( -LRB- cord-023134-y665agnh 969 56 0.01 0.01 CD cord-023134-y665agnh 969 57 - - SYM cord-023134-y665agnh 969 58 3.07 3.07 CD cord-023134-y665agnh 969 59 ) ) -RRB- cord-023134-y665agnh 969 60 , , , cord-023134-y665agnh 969 61 704 704 CD cord-023134-y665agnh 969 62 ( ( -LRB- cord-023134-y665agnh 969 63 563 563 CD cord-023134-y665agnh 969 64 - - SYM cord-023134-y665agnh 969 65 1,002 1,002 CD cord-023134-y665agnh 969 66 ) ) -RRB- cord-023134-y665agnh 969 67 and and CC cord-023134-y665agnh 969 68 302 302 CD cord-023134-y665agnh 969 69 ( ( -LRB- cord-023134-y665agnh 969 70 94 94 CD cord-023134-y665agnh 969 71 - - SYM cord-023134-y665agnh 969 72 566 566 CD cord-023134-y665agnh 969 73 ) ) -RRB- cord-023134-y665agnh 969 74 , , , cord-023134-y665agnh 969 75 respectively respectively RB cord-023134-y665agnh 969 76 , , , cord-023134-y665agnh 969 77 at at IN cord-023134-y665agnh 969 78 Td1 td1 CD cord-023134-y665agnh 969 79 . . . cord-023134-y665agnh 970 1 On on IN cord-023134-y665agnh 970 2 admission admission NN cord-023134-y665agnh 970 3 , , , cord-023134-y665agnh 970 4 serum serum NN cord-023134-y665agnh 970 5 CRP crp NN cord-023134-y665agnh 970 6 , , , cord-023134-y665agnh 970 7 amylase amylase NN cord-023134-y665agnh 970 8 and and CC cord-023134-y665agnh 970 9 lipase lipase NN cord-023134-y665agnh 970 10 levels level NNS cord-023134-y665agnh 970 11 were be VBD cord-023134-y665agnh 970 12 increased increase VBN cord-023134-y665agnh 970 13 in in IN cord-023134-y665agnh 970 14 100 100 CD cord-023134-y665agnh 970 15 % % NN cord-023134-y665agnh 970 16 , , , cord-023134-y665agnh 970 17 77 77 CD cord-023134-y665agnh 970 18 % % NN cord-023134-y665agnh 970 19 , , , cord-023134-y665agnh 970 20 and and CC cord-023134-y665agnh 970 21 55 55 CD cord-023134-y665agnh 970 22 % % NN cord-023134-y665agnh 970 23 of of IN cord-023134-y665agnh 970 24 dogs dog NNS cord-023134-y665agnh 970 25 , , , cord-023134-y665agnh 970 26 respectively respectively RB cord-023134-y665agnh 970 27 while while IN cord-023134-y665agnh 970 28 they -PRON- PRP cord-023134-y665agnh 970 29 were be VBD cord-023134-y665agnh 970 30 increased increase VBN cord-023134-y665agnh 970 31 in in IN cord-023134-y665agnh 970 32 50 50 CD cord-023134-y665agnh 970 33 % % NN cord-023134-y665agnh 970 34 , , , cord-023134-y665agnh 970 35 12.5 12.5 CD cord-023134-y665agnh 970 36 % % NN cord-023134-y665agnh 970 37 and and CC cord-023134-y665agnh 970 38 0 0 CD cord-023134-y665agnh 970 39 % % NN cord-023134-y665agnh 970 40 of of IN cord-023134-y665agnh 970 41 dogs dog NNS cord-023134-y665agnh 970 42 , , , cord-023134-y665agnh 970 43 respectively respectively RB cord-023134-y665agnh 970 44 , , , cord-023134-y665agnh 970 45 at at IN cord-023134-y665agnh 970 46 Td1 td1 CD cord-023134-y665agnh 970 47 . . . cord-023134-y665agnh 971 1 Serum serum NN cord-023134-y665agnh 971 2 CRP crp NN cord-023134-y665agnh 971 3 and and CC cord-023134-y665agnh 971 4 amylase amylase NN cord-023134-y665agnh 971 5 , , , cord-023134-y665agnh 971 6 but but CC cord-023134-y665agnh 971 7 not not RB cord-023134-y665agnh 971 8 lipase lipase NN cord-023134-y665agnh 971 9 , , , cord-023134-y665agnh 971 10 concentrations concentration NNS cord-023134-y665agnh 971 11 decreased decrease VBD cord-023134-y665agnh 971 12 during during IN cord-023134-y665agnh 971 13 the the DT cord-023134-y665agnh 971 14 follow follow NN cord-023134-y665agnh 971 15 up up RP cord-023134-y665agnh 971 16 and and CC cord-023134-y665agnh 971 17 were be VBD cord-023134-y665agnh 971 18 significantly significantly RB cord-023134-y665agnh 971 19 ( ( -LRB- cord-023134-y665agnh 971 20 p p NN cord-023134-y665agnh 971 21 < < XX cord-023134-y665agnh 971 22 0.05 0.05 CD cord-023134-y665agnh 971 23 ) ) -RRB- cord-023134-y665agnh 971 24 lower low JJR cord-023134-y665agnh 971 25 at at IN cord-023134-y665agnh 971 26 Td1 td1 CD cord-023134-y665agnh 971 27 compared compare VBN cord-023134-y665agnh 971 28 to to IN cord-023134-y665agnh 971 29 T0.Results T0.Results NNP cord-023134-y665agnh 971 30 suggest suggest VBP cord-023134-y665agnh 971 31 that that IN cord-023134-y665agnh 971 32 US US NNP cord-023134-y665agnh 971 33 findings finding NNS cord-023134-y665agnh 971 34 , , , cord-023134-y665agnh 971 35 and and CC cord-023134-y665agnh 971 36 CRP crp NN cord-023134-y665agnh 971 37 and and CC cord-023134-y665agnh 971 38 amylase amylase NN cord-023134-y665agnh 971 39 concentrations concentration NNS cord-023134-y665agnh 971 40 are be VBP cord-023134-y665agnh 971 41 correlated correlate VBN cord-023134-y665agnh 971 42 with with IN cord-023134-y665agnh 971 43 the the DT cord-023134-y665agnh 971 44 recovery recovery NN cord-023134-y665agnh 971 45 from from IN cord-023134-y665agnh 971 46 the the DT cord-023134-y665agnh 971 47 AP AP NNP cord-023134-y665agnh 971 48 . . . cord-023134-y665agnh 972 1 Further further JJ cord-023134-y665agnh 972 2 studies study NNS cord-023134-y665agnh 972 3 are be VBP cord-023134-y665agnh 972 4 warranted warrant VBN cord-023134-y665agnh 972 5 to to TO cord-023134-y665agnh 972 6 evaluate evaluate VB cord-023134-y665agnh 972 7 the the DT cord-023134-y665agnh 972 8 usefulness usefulness NN cord-023134-y665agnh 972 9 of of IN cord-023134-y665agnh 972 10 these these DT cord-023134-y665agnh 972 11 parameters parameter NNS cord-023134-y665agnh 972 12 in in IN cord-023134-y665agnh 972 13 the the DT cord-023134-y665agnh 972 14 follow follow NN cord-023134-y665agnh 972 15 - - HYPH cord-023134-y665agnh 972 16 up up NN cord-023134-y665agnh 972 17 of of IN cord-023134-y665agnh 972 18 AP AP NNP cord-023134-y665agnh 972 19 in in IN cord-023134-y665agnh 972 20 a a DT cord-023134-y665agnh 972 21 wider wide JJR cord-023134-y665agnh 972 22 population population NN cord-023134-y665agnh 972 23 of of IN cord-023134-y665agnh 972 24 dogs dog NNS cord-023134-y665agnh 972 25 . . . cord-023134-y665agnh 973 1 Enzyme enzyme NN cord-023134-y665agnh 973 2 replacement replacement NN cord-023134-y665agnh 973 3 therapy therapy NN cord-023134-y665agnh 973 4 is be VBZ cord-023134-y665agnh 973 5 the the DT cord-023134-y665agnh 973 6 mainstay mainstay NN cord-023134-y665agnh 973 7 therapy therapy NN cord-023134-y665agnh 973 8 for for IN cord-023134-y665agnh 973 9 exocrine exocrine JJ cord-023134-y665agnh 973 10 pancreatic pancreatic JJ cord-023134-y665agnh 973 11 insufficiency insufficiency NN cord-023134-y665agnh 973 12 ( ( -LRB- cord-023134-y665agnh 973 13 EPI EPI NNP cord-023134-y665agnh 973 14 ) ) -RRB- cord-023134-y665agnh 973 15 in in IN cord-023134-y665agnh 973 16 dogs dog NNS cord-023134-y665agnh 973 17 . . . cord-023134-y665agnh 973 18 ' ' '' cord-023134-y665agnh 974 1 Enteric enteric JJ cord-023134-y665agnh 974 2 - - HYPH cord-023134-y665agnh 974 3 coated coated JJ cord-023134-y665agnh 974 4 ' ' POS cord-023134-y665agnh 974 5 preparations preparation NNS cord-023134-y665agnh 974 6 have have VBP cord-023134-y665agnh 974 7 been be VBN cord-023134-y665agnh 974 8 developed develop VBN cord-023134-y665agnh 974 9 to to TO cord-023134-y665agnh 974 10 protect protect VB cord-023134-y665agnh 974 11 the the DT cord-023134-y665agnh 974 12 enzyme enzyme NN cord-023134-y665agnh 974 13 from from IN cord-023134-y665agnh 974 14 degradation degradation NN cord-023134-y665agnh 974 15 in in IN cord-023134-y665agnh 974 16 the the DT cord-023134-y665agnh 974 17 stomach stomach NN cord-023134-y665agnh 974 18 , , , cord-023134-y665agnh 974 19 but but CC cord-023134-y665agnh 974 20 their -PRON- PRP$ cord-023134-y665agnh 974 21 efficacy efficacy NN cord-023134-y665agnh 974 22 has have VBZ cord-023134-y665agnh 974 23 not not RB cord-023134-y665agnh 974 24 been be VBN cord-023134-y665agnh 974 25 critically critically RB cord-023134-y665agnh 974 26 evaluated evaluate VBN cord-023134-y665agnh 974 27 . . . cord-023134-y665agnh 975 1 The the DT cord-023134-y665agnh 975 2 hypothesis hypothesis NN cord-023134-y665agnh 975 3 of of IN cord-023134-y665agnh 975 4 the the DT cord-023134-y665agnh 975 5 current current JJ cord-023134-y665agnh 975 6 study study NN cord-023134-y665agnh 975 7 was be VBD cord-023134-y665agnh 975 8 that that IN cord-023134-y665agnh 975 9 enteric enteric JJ cord-023134-y665agnh 975 10 coating coating NN cord-023134-y665agnh 975 11 would would MD cord-023134-y665agnh 975 12 have have VB cord-023134-y665agnh 975 13 no no DT cord-023134-y665agnh 975 14 effect effect NN cord-023134-y665agnh 975 15 on on IN cord-023134-y665agnh 975 16 the the DT cord-023134-y665agnh 975 17 efficacy efficacy NN cord-023134-y665agnh 975 18 of of IN cord-023134-y665agnh 975 19 pancreatic pancreatic JJ cord-023134-y665agnh 975 20 enzyme enzyme NN cord-023134-y665agnh 975 21 supplements supplement NNS cord-023134-y665agnh 975 22 for for IN cord-023134-y665agnh 975 23 dogs dog NNS cord-023134-y665agnh 975 24 with with IN cord-023134-y665agnh 975 25 EPI.Thirty EPI.Thirty NNP cord-023134-y665agnh 975 26 - - HYPH cord-023134-y665agnh 975 27 eight eight CD cord-023134-y665agnh 975 28 client client NN cord-023134-y665agnh 975 29 - - HYPH cord-023134-y665agnh 975 30 owned own VBN cord-023134-y665agnh 975 31 dogs dog NNS cord-023134-y665agnh 975 32 with with IN cord-023134-y665agnh 975 33 naturally naturally RB cord-023134-y665agnh 975 34 occurring occur VBG cord-023134-y665agnh 975 35 EPI EPI NNP cord-023134-y665agnh 975 36 were be VBD cord-023134-y665agnh 975 37 included include VBN cord-023134-y665agnh 975 38 in in IN cord-023134-y665agnh 975 39 this this DT cord-023134-y665agnh 975 40 multicentre multicentre NNP cord-023134-y665agnh 975 41 , , , cord-023134-y665agnh 975 42 blinded blinded JJ cord-023134-y665agnh 975 43 , , , cord-023134-y665agnh 975 44 randomised randomised JJ cord-023134-y665agnh 975 45 controlled control VBN cord-023134-y665agnh 975 46 trial trial NN cord-023134-y665agnh 975 47 . . . cord-023134-y665agnh 976 1 Dogs dog NNS cord-023134-y665agnh 976 2 received receive VBD cord-023134-y665agnh 976 3 either either CC cord-023134-y665agnh 976 4 an an DT cord-023134-y665agnh 976 5 enteric enteric JJ cord-023134-y665agnh 976 6 - - HYPH cord-023134-y665agnh 976 7 coated coated JJ cord-023134-y665agnh 976 8 enzyme enzyme NN cord-023134-y665agnh 976 9 preparation preparation NN cord-023134-y665agnh 976 10 ( ( -LRB- cord-023134-y665agnh 976 11 test test NN cord-023134-y665agnh 976 12 group group NN cord-023134-y665agnh 976 13 ) ) -RRB- cord-023134-y665agnh 976 14 or or CC cord-023134-y665agnh 976 15 an an DT cord-023134-y665agnh 976 16 identical identical JJ cord-023134-y665agnh 976 17 preparation preparation NN cord-023134-y665agnh 976 18 without without IN cord-023134-y665agnh 976 19 the the DT cord-023134-y665agnh 976 20 enteric enteric JJ cord-023134-y665agnh 976 21 coating coating NN cord-023134-y665agnh 976 22 ( ( -LRB- cord-023134-y665agnh 976 23 control control NN cord-023134-y665agnh 976 24 group group NN cord-023134-y665agnh 976 25 ) ) -RRB- cord-023134-y665agnh 976 26 over over IN cord-023134-y665agnh 976 27 a a DT cord-023134-y665agnh 976 28 period period NN cord-023134-y665agnh 976 29 of of IN cord-023134-y665agnh 976 30 56 56 CD cord-023134-y665agnh 976 31 days day NNS cord-023134-y665agnh 976 32 . . . cord-023134-y665agnh 977 1 There there EX cord-023134-y665agnh 977 2 were be VBD cord-023134-y665agnh 977 3 no no DT cord-023134-y665agnh 977 4 significant significant JJ cord-023134-y665agnh 977 5 differences difference NNS cord-023134-y665agnh 977 6 in in IN cord-023134-y665agnh 977 7 baseline baseline JJ cord-023134-y665agnh 977 8 characteristics characteristic NNS cord-023134-y665agnh 977 9 between between IN cord-023134-y665agnh 977 10 test test NN cord-023134-y665agnh 977 11 and and CC cord-023134-y665agnh 977 12 control control NN cord-023134-y665agnh 977 13 treatment treatment NN cord-023134-y665agnh 977 14 groups group NNS cord-023134-y665agnh 977 15 . . . cord-023134-y665agnh 978 1 Body body NN cord-023134-y665agnh 978 2 weight weight NN cord-023134-y665agnh 978 3 and and CC cord-023134-y665agnh 978 4 body body NN cord-023134-y665agnh 978 5 condition condition NN cord-023134-y665agnh 978 6 score score NN cord-023134-y665agnh 978 7 increased increase VBD cord-023134-y665agnh 978 8 in in IN cord-023134-y665agnh 978 9 both both DT cord-023134-y665agnh 978 10 groups group NNS cord-023134-y665agnh 978 11 during during IN cord-023134-y665agnh 978 12 the the DT cord-023134-y665agnh 978 13 trial trial NN cord-023134-y665agnh 978 14 ( ( -LRB- cord-023134-y665agnh 978 15 P<0.001 P<0.001 NNP cord-023134-y665agnh 978 16 ) ) -RRB- cord-023134-y665agnh 978 17 but but CC cord-023134-y665agnh 978 18 the the DT cord-023134-y665agnh 978 19 magnitude magnitude NN cord-023134-y665agnh 978 20 of of IN cord-023134-y665agnh 978 21 increase increase NN cord-023134-y665agnh 978 22 was be VBD cord-023134-y665agnh 978 23 greater great JJR cord-023134-y665agnh 978 24 for for IN cord-023134-y665agnh 978 25 the the DT cord-023134-y665agnh 978 26 test test NN cord-023134-y665agnh 978 27 treatment treatment NN cord-023134-y665agnh 978 28 compared compare VBN cord-023134-y665agnh 978 29 with with IN cord-023134-y665agnh 978 30 the the DT cord-023134-y665agnh 978 31 control control NN cord-023134-y665agnh 978 32 treatment treatment NN cord-023134-y665agnh 978 33 ( ( -LRB- cord-023134-y665agnh 978 34 P<0.001 P<0.001 NNP cord-023134-y665agnh 978 35 ) ) -RRB- cord-023134-y665agnh 978 36 . . . cord-023134-y665agnh 979 1 By by IN cord-023134-y665agnh 979 2 day day NN cord-023134-y665agnh 979 3 56 56 CD cord-023134-y665agnh 979 4 , , , cord-023134-y665agnh 979 5 mean mean VB cord-023134-y665agnh 979 6 body body NN cord-023134-y665agnh 979 7 weight weight NN cord-023134-y665agnh 979 8 increase increase NN cord-023134-y665agnh 979 9 was be VBD cord-023134-y665agnh 979 10 17 17 CD cord-023134-y665agnh 979 11 % % NN cord-023134-y665agnh 979 12 ( ( -LRB- cord-023134-y665agnh 979 13 95 95 CD cord-023134-y665agnh 979 14 % % NN cord-023134-y665agnh 979 15 confidence confidence NN cord-023134-y665agnh 979 16 interval interval NN cord-023134-y665agnh 979 17 11 11 CD cord-023134-y665agnh 979 18 - - SYM cord-023134-y665agnh 979 19 23 23 CD cord-023134-y665agnh 979 20 % % NN cord-023134-y665agnh 979 21 ) ) -RRB- cord-023134-y665agnh 979 22 in in IN cord-023134-y665agnh 979 23 the the DT cord-023134-y665agnh 979 24 treatment treatment NN cord-023134-y665agnh 979 25 group group NN cord-023134-y665agnh 979 26 and and CC cord-023134-y665agnh 979 27 9 9 CD cord-023134-y665agnh 979 28 % % NN cord-023134-y665agnh 979 29 ( ( -LRB- cord-023134-y665agnh 979 30 95 95 CD cord-023134-y665agnh 979 31 % % NN cord-023134-y665agnh 979 32 confidence confidence NN cord-023134-y665agnh 979 33 interval interval NN cord-023134-y665agnh 979 34 4 4 CD cord-023134-y665agnh 979 35 - - SYM cord-023134-y665agnh 979 36 15 15 CD cord-023134-y665agnh 979 37 % % NN cord-023134-y665agnh 979 38 ) ) -RRB- cord-023134-y665agnh 979 39 in in IN cord-023134-y665agnh 979 40 the the DT cord-023134-y665agnh 979 41 control control NN cord-023134-y665agnh 979 42 group group NN cord-023134-y665agnh 979 43 . . . cord-023134-y665agnh 980 1 The the DT cord-023134-y665agnh 980 2 dose dose NN cord-023134-y665agnh 980 3 of of IN cord-023134-y665agnh 980 4 enzyme enzyme NN cord-023134-y665agnh 980 5 used use VBN cord-023134-y665agnh 980 6 increased increase VBN cord-023134-y665agnh 980 7 over over IN cord-023134-y665agnh 980 8 time time NN cord-023134-y665agnh 980 9 ( ( -LRB- cord-023134-y665agnh 980 10 P<0.001 P<0.001 NNS cord-023134-y665agnh 980 11 ) ) -RRB- cord-023134-y665agnh 980 12 but but CC cord-023134-y665agnh 980 13 there there EX cord-023134-y665agnh 980 14 was be VBD cord-023134-y665agnh 980 15 no no DT cord-023134-y665agnh 980 16 significant significant JJ cord-023134-y665agnh 980 17 treatment treatment NN cord-023134-y665agnh 980 18 group group NN cord-023134-y665agnh 980 19 difference difference NN cord-023134-y665agnh 980 20 at at IN cord-023134-y665agnh 980 21 any any DT cord-023134-y665agnh 980 22 time time NN cord-023134-y665agnh 980 23 point point NN cord-023134-y665agnh 980 24 ( ( -LRB- cord-023134-y665agnh 980 25 P=0.225 P=0.225 NNP cord-023134-y665agnh 980 26 ) ) -RRB- cord-023134-y665agnh 980 27 . . . cord-023134-y665agnh 981 1 Clinical clinical JJ cord-023134-y665agnh 981 2 disease disease NN cord-023134-y665agnh 981 3 severity severity NN cord-023134-y665agnh 981 4 score score NN cord-023134-y665agnh 981 5 decreased decrease VBD cord-023134-y665agnh 981 6 significantly significantly RB cord-023134-y665agnh 981 7 over over IN cord-023134-y665agnh 981 8 time time NN cord-023134-y665agnh 981 9 for for IN cord-023134-y665agnh 981 10 both both DT cord-023134-y665agnh 981 11 groups group NNS cord-023134-y665agnh 981 12 ( ( -LRB- cord-023134-y665agnh 981 13 P=0.011 P=0.011 NNP cord-023134-y665agnh 981 14 ) ) -RRB- cord-023134-y665agnh 981 15 and and CC cord-023134-y665agnh 981 16 no no DT cord-023134-y665agnh 981 17 significant significant JJ cord-023134-y665agnh 981 18 difference difference NN cord-023134-y665agnh 981 19 was be VBD cord-023134-y665agnh 981 20 noted note VBN cord-023134-y665agnh 981 21 between between IN cord-023134-y665agnh 981 22 groups group NNS cord-023134-y665agnh 981 23 ( ( -LRB- cord-023134-y665agnh 981 24 P=0.869 p=0.869 NN cord-023134-y665agnh 981 25 ) ) -RRB- cord-023134-y665agnh 981 26 . . . cord-023134-y665agnh 982 1 No no DT cord-023134-y665agnh 982 2 significant significant JJ cord-023134-y665agnh 982 3 adverse adverse JJ cord-023134-y665agnh 982 4 effects effect NNS cord-023134-y665agnh 982 5 were be VBD cord-023134-y665agnh 982 6 reported report VBN cord-023134-y665agnh 982 7 , , , cord-023134-y665agnh 982 8 for for IN cord-023134-y665agnh 982 9 either either DT cord-023134-y665agnh 982 10 treatment treatment NN cord-023134-y665agnh 982 11 , , , cord-023134-y665agnh 982 12 for for IN cord-023134-y665agnh 982 13 the the DT cord-023134-y665agnh 982 14 duration duration NN cord-023134-y665agnh 982 15 of of IN cord-023134-y665agnh 982 16 the the DT cord-023134-y665agnh 982 17 trial trial NN cord-023134-y665agnh 982 18 . . . cord-023134-y665agnh 983 1 Adding add VBG cord-023134-y665agnh 983 2 an an DT cord-023134-y665agnh 983 3 enteric enteric JJ cord-023134-y665agnh 983 4 coating coating NN cord-023134-y665agnh 983 5 to to IN cord-023134-y665agnh 983 6 a a DT cord-023134-y665agnh 983 7 pancreatic pancreatic JJ cord-023134-y665agnh 983 8 enzyme enzyme NN cord-023134-y665agnh 983 9 supplement supplement NN cord-023134-y665agnh 983 10 conveys convey VBZ cord-023134-y665agnh 983 11 a a DT cord-023134-y665agnh 983 12 therapeutic therapeutic JJ cord-023134-y665agnh 983 13 advantage advantage NN cord-023134-y665agnh 983 14 , , , cord-023134-y665agnh 983 15 when when WRB cord-023134-y665agnh 983 16 treating treat VBG cord-023134-y665agnh 983 17 dogs dog NNS cord-023134-y665agnh 983 18 with with IN cord-023134-y665agnh 983 19 EPI EPI NNP cord-023134-y665agnh 983 20 . . . cord-023134-y665agnh 984 1 When when WRB cord-023134-y665agnh 984 2 liver liver NN cord-023134-y665agnh 984 3 injury injury NN cord-023134-y665agnh 984 4 is be VBZ cord-023134-y665agnh 984 5 caused cause VBN cord-023134-y665agnh 984 6 by by IN cord-023134-y665agnh 984 7 toxins toxin NNS cord-023134-y665agnh 984 8 that that WDT cord-023134-y665agnh 984 9 inhibit inhibit VBP cord-023134-y665agnh 984 10 hepatocyte hepatocyte NN cord-023134-y665agnh 984 11 replication replication NN cord-023134-y665agnh 984 12 , , , cord-023134-y665agnh 984 13 or or CC cord-023134-y665agnh 984 14 when when WRB cord-023134-y665agnh 984 15 the the DT cord-023134-y665agnh 984 16 proliferative proliferative JJ cord-023134-y665agnh 984 17 potential potential NN cord-023134-y665agnh 984 18 of of IN cord-023134-y665agnh 984 19 hepatocytes hepatocyte NNS cord-023134-y665agnh 984 20 is be VBZ cord-023134-y665agnh 984 21 exhausted exhaust VBN cord-023134-y665agnh 984 22 due due IN cord-023134-y665agnh 984 23 to to IN cord-023134-y665agnh 984 24 the the DT cord-023134-y665agnh 984 25 chronic chronic JJ cord-023134-y665agnh 984 26 condition condition NN cord-023134-y665agnh 984 27 of of IN cord-023134-y665agnh 984 28 the the DT cord-023134-y665agnh 984 29 disease disease NN cord-023134-y665agnh 984 30 , , , cord-023134-y665agnh 984 31 hepatocyte hepatocyte NN cord-023134-y665agnh 984 32 - - HYPH cord-023134-y665agnh 984 33 dependent dependent JJ cord-023134-y665agnh 984 34 liver liver NN cord-023134-y665agnh 984 35 regeneration regeneration NN cord-023134-y665agnh 984 36 is be VBZ cord-023134-y665agnh 984 37 strongly strongly RB cord-023134-y665agnh 984 38 impaired impaired JJ cord-023134-y665agnh 984 39 . . . cord-023134-y665agnh 985 1 In in IN cord-023134-y665agnh 985 2 this this DT cord-023134-y665agnh 985 3 situation situation NN cord-023134-y665agnh 985 4 another another DT cord-023134-y665agnh 985 5 cell cell NN cord-023134-y665agnh 985 6 compartment compartment NN cord-023134-y665agnh 985 7 is be VBZ cord-023134-y665agnh 985 8 activated activate VBN cord-023134-y665agnh 985 9 to to TO cord-023134-y665agnh 985 10 regenerate regenerate VB cord-023134-y665agnh 985 11 the the DT cord-023134-y665agnh 985 12 liver liver NN cord-023134-y665agnh 985 13 : : : cord-023134-y665agnh 985 14 the the DT cord-023134-y665agnh 985 15 hepatic hepatic JJ cord-023134-y665agnh 985 16 progenitor progenitor NN cord-023134-y665agnh 985 17 cell cell NN cord-023134-y665agnh 985 18 compartment compartment NN cord-023134-y665agnh 985 19 . . . cord-023134-y665agnh 986 1 Bipotent Bipotent NNP cord-023134-y665agnh 986 2 hepatic hepatic JJ cord-023134-y665agnh 986 3 progenitor progenitor NN cord-023134-y665agnh 986 4 cells cell NNS cord-023134-y665agnh 986 5 ( ( -LRB- cord-023134-y665agnh 986 6 HPCs hpc NNS cord-023134-y665agnh 986 7 ) ) -RRB- cord-023134-y665agnh 986 8 can can MD cord-023134-y665agnh 986 9 differentiate differentiate VB cord-023134-y665agnh 986 10 into into IN cord-023134-y665agnh 986 11 hepatocytes hepatocyte NNS cord-023134-y665agnh 986 12 or or CC cord-023134-y665agnh 986 13 cholangiocytes cholangiocyte NNS cord-023134-y665agnh 986 14 . . . cord-023134-y665agnh 987 1 Not not RB cord-023134-y665agnh 987 2 only only RB cord-023134-y665agnh 987 3 are be VBP cord-023134-y665agnh 987 4 HPCs hpc NNS cord-023134-y665agnh 987 5 activated activate VBN cord-023134-y665agnh 987 6 during during IN cord-023134-y665agnh 987 7 severe severe JJ cord-023134-y665agnh 987 8 liver liver NN cord-023134-y665agnh 987 9 disease disease NN cord-023134-y665agnh 987 10 , , , cord-023134-y665agnh 987 11 they -PRON- PRP cord-023134-y665agnh 987 12 may may MD cord-023134-y665agnh 987 13 well well RB cord-023134-y665agnh 987 14 be be VB cord-023134-y665agnh 987 15 the the DT cord-023134-y665agnh 987 16 cells cell NNS cord-023134-y665agnh 987 17 of of IN cord-023134-y665agnh 987 18 origin origin NN cord-023134-y665agnh 987 19 for for IN cord-023134-y665agnh 987 20 subtypes subtype NNS cord-023134-y665agnh 987 21 of of IN cord-023134-y665agnh 987 22 hepatocellular hepatocellular JJ cord-023134-y665agnh 987 23 carcinoma carcinoma NN cord-023134-y665agnh 987 24 ( ( -LRB- cord-023134-y665agnh 987 25 HCC).The hcc).the ADD cord-023134-y665agnh 988 1 Polycomb Polycomb NNP cord-023134-y665agnh 988 2 Group Group NNP cord-023134-y665agnh 988 3 protein protein NN cord-023134-y665agnh 988 4 Bmi1 Bmi1 NNP cord-023134-y665agnh 988 5 is be VBZ cord-023134-y665agnh 988 6 involved involve VBN cord-023134-y665agnh 988 7 in in IN cord-023134-y665agnh 988 8 murine murine JJ cord-023134-y665agnh 988 9 HPC HPC NNP cord-023134-y665agnh 988 10 activation activation NN cord-023134-y665agnh 988 11 and and CC cord-023134-y665agnh 988 12 has have VBZ cord-023134-y665agnh 988 13 prognostic prognostic JJ cord-023134-y665agnh 988 14 relevance relevance NN cord-023134-y665agnh 988 15 in in IN cord-023134-y665agnh 988 16 HCC HCC NNP cord-023134-y665agnh 988 17 . . . cord-023134-y665agnh 989 1 Therefore therefore RB cord-023134-y665agnh 989 2 we -PRON- PRP cord-023134-y665agnh 989 3 investigated investigate VBD cord-023134-y665agnh 989 4 the the DT cord-023134-y665agnh 989 5 expression expression NN cord-023134-y665agnh 989 6 of of IN cord-023134-y665agnh 989 7 Bmi1 Bmi1 NNP cord-023134-y665agnh 989 8 in in IN cord-023134-y665agnh 989 9 canine canine JJ cord-023134-y665agnh 989 10 liver liver NN cord-023134-y665agnh 989 11 diseases disease NNS cord-023134-y665agnh 989 12 including include VBG cord-023134-y665agnh 989 13 HCC HCC NNP cord-023134-y665agnh 989 14 . . . cord-023134-y665agnh 990 1 Functional functional JJ cord-023134-y665agnh 990 2 consequences consequence NNS cord-023134-y665agnh 990 3 of of IN cord-023134-y665agnh 990 4 deregulated deregulate VBN cord-023134-y665agnh 990 5 Bmi1 Bmi1 NNP cord-023134-y665agnh 990 6 expression expression NN cord-023134-y665agnh 990 7 are be VBP cord-023134-y665agnh 990 8 included include VBN cord-023134-y665agnh 990 9 to to TO cord-023134-y665agnh 990 10 reveal reveal VB cord-023134-y665agnh 990 11 its -PRON- PRP$ cord-023134-y665agnh 990 12 feasibility feasibility NN cord-023134-y665agnh 990 13 in in IN cord-023134-y665agnh 990 14 liver liver NN cord-023134-y665agnh 990 15 regenerative regenerative JJ cord-023134-y665agnh 990 16 medicine medicine NN cord-023134-y665agnh 990 17 . . . cord-023134-y665agnh 991 1 Immunohistochemistry Immunohistochemistry NNP cord-023134-y665agnh 991 2 ( ( -LRB- cord-023134-y665agnh 991 3 IHC IHC NNP cord-023134-y665agnh 991 4 ) ) -RRB- cord-023134-y665agnh 991 5 and and CC cord-023134-y665agnh 991 6 laser laser NN cord-023134-y665agnh 991 7 microdissection microdissection NN cord-023134-y665agnh 991 8 followed follow VBN cord-023134-y665agnh 991 9 by by IN cord-023134-y665agnh 991 10 gene gene NN cord-023134-y665agnh 991 11 expression expression NN cord-023134-y665agnh 991 12 analysis analysis NN cord-023134-y665agnh 991 13 were be VBD cord-023134-y665agnh 991 14 used use VBN cord-023134-y665agnh 991 15 to to TO cord-023134-y665agnh 991 16 investigate investigate VB cord-023134-y665agnh 991 17 the the DT cord-023134-y665agnh 991 18 expression expression NN cord-023134-y665agnh 991 19 of of IN cord-023134-y665agnh 991 20 Bmi1 Bmi1 NNP cord-023134-y665agnh 991 21 in in IN cord-023134-y665agnh 991 22 activated activate VBN cord-023134-y665agnh 991 23 HPCs hpc NNS cord-023134-y665agnh 991 24 and and CC cord-023134-y665agnh 991 25 HCC HCC NNP cord-023134-y665agnh 991 26 . . . cord-023134-y665agnh 992 1 To to TO cord-023134-y665agnh 992 2 elucidate elucidate VB cord-023134-y665agnh 992 3 the the DT cord-023134-y665agnh 992 4 role role NN cord-023134-y665agnh 992 5 of of IN cord-023134-y665agnh 992 6 Bmi1 Bmi1 NNP cord-023134-y665agnh 992 7 in in IN cord-023134-y665agnh 992 8 HPCs hpc NNS cord-023134-y665agnh 992 9 , , , cord-023134-y665agnh 992 10 in in IN cord-023134-y665agnh 992 11 vitro vitro FW cord-023134-y665agnh 992 12 gene gene NN cord-023134-y665agnh 992 13 silencing silence VBG cord-023134-y665agnh 992 14 experiments experiment NNS cord-023134-y665agnh 992 15 followed follow VBN cord-023134-y665agnh 992 16 by by IN cord-023134-y665agnh 992 17 gene gene NN cord-023134-y665agnh 992 18 expression expression NN cord-023134-y665agnh 992 19 analysis analysis NN cord-023134-y665agnh 992 20 , , , cord-023134-y665agnh 992 21 western western JJ cord-023134-y665agnh 992 22 blot blot NN cord-023134-y665agnh 992 23 analysis analysis NN cord-023134-y665agnh 992 24 , , , cord-023134-y665agnh 992 25 and and CC cord-023134-y665agnh 992 26 a a DT cord-023134-y665agnh 992 27 proliferation proliferation NN cord-023134-y665agnh 992 28 assay assay NN cord-023134-y665agnh 992 29 ( ( -LRB- cord-023134-y665agnh 992 30 EdU edu NN cord-023134-y665agnh 992 31 - - HYPH cord-023134-y665agnh 992 32 incorporation incorporation NN cord-023134-y665agnh 992 33 ) ) -RRB- cord-023134-y665agnh 992 34 were be VBD cord-023134-y665agnh 992 35 performed perform VBN cord-023134-y665agnh 992 36 in in IN cord-023134-y665agnh 992 37 the the DT cord-023134-y665agnh 992 38 human human JJ cord-023134-y665agnh 992 39 HPC hpc NN cord-023134-y665agnh 992 40 - - HYPH cord-023134-y665agnh 992 41 like like JJ cord-023134-y665agnh 992 42 cell cell NN cord-023134-y665agnh 992 43 - - HYPH cord-023134-y665agnh 992 44 line line NN cord-023134-y665agnh 993 1 HepaRG.IHC heparg.ihc NN cord-023134-y665agnh 993 2 and and CC cord-023134-y665agnh 993 3 gene gene NN cord-023134-y665agnh 993 4 expression expression NN cord-023134-y665agnh 993 5 showed show VBD cord-023134-y665agnh 993 6 a a DT cord-023134-y665agnh 993 7 strong strong JJ cord-023134-y665agnh 993 8 nuclear nuclear JJ cord-023134-y665agnh 993 9 expression expression NN cord-023134-y665agnh 993 10 of of IN cord-023134-y665agnh 993 11 Bmi1 Bmi1 NNP cord-023134-y665agnh 993 12 in in IN cord-023134-y665agnh 993 13 activated activate VBN cord-023134-y665agnh 993 14 HPCs hpc NNS cord-023134-y665agnh 993 15 in in IN cord-023134-y665agnh 993 16 canine canine JJ cord-023134-y665agnh 993 17 liver liver NN cord-023134-y665agnh 993 18 diseases disease NNS cord-023134-y665agnh 993 19 . . . cord-023134-y665agnh 994 1 Keratin keratin NN cord-023134-y665agnh 994 2 19 19 CD cord-023134-y665agnh 994 3 is be VBZ cord-023134-y665agnh 994 4 a a DT cord-023134-y665agnh 994 5 marker marker NN cord-023134-y665agnh 994 6 for for IN cord-023134-y665agnh 994 7 HPCs hpc NNS cord-023134-y665agnh 994 8 and and CC cord-023134-y665agnh 994 9 cholangiocytes cholangiocyte NNS cord-023134-y665agnh 994 10 , , , cord-023134-y665agnh 994 11 and and CC cord-023134-y665agnh 994 12 high high JJ cord-023134-y665agnh 994 13 expression expression NN cord-023134-y665agnh 994 14 is be VBZ cord-023134-y665agnh 994 15 associated associate VBN cord-023134-y665agnh 994 16 with with IN cord-023134-y665agnh 994 17 poor poor JJ cord-023134-y665agnh 994 18 prognosis prognosis NN cord-023134-y665agnh 994 19 in in IN cord-023134-y665agnh 994 20 HCCS HCCS NNP cord-023134-y665agnh 994 21 . . . cord-023134-y665agnh 995 1 Bmi1 bmi1 JJ cord-023134-y665agnh 995 2 staining staining NN cord-023134-y665agnh 995 3 was be VBD cord-023134-y665agnh 995 4 more more RBR cord-023134-y665agnh 995 5 intense intense JJ cord-023134-y665agnh 995 6 in in IN cord-023134-y665agnh 995 7 highly highly RB cord-023134-y665agnh 995 8 malignant malignant JJ cord-023134-y665agnh 995 9 hepatocellular hepatocellular JJ cord-023134-y665agnh 995 10 carcinomas carcinoma NNS cord-023134-y665agnh 995 11 positive positive JJ cord-023134-y665agnh 995 12 for for IN cord-023134-y665agnh 995 13 Keratin keratin NN cord-023134-y665agnh 995 14 19 19 CD cord-023134-y665agnh 995 15 compared compare VBN cord-023134-y665agnh 995 16 to to IN cord-023134-y665agnh 995 17 Keratin keratin NN cord-023134-y665agnh 995 18 19 19 CD cord-023134-y665agnh 995 19 negative negative JJ cord-023134-y665agnh 995 20 HCCs hcc NNS cord-023134-y665agnh 995 21 . . . cord-023134-y665agnh 996 1 Bmi1-silencing Bmi1-silencing NNP cord-023134-y665agnh 997 1 in in FW cord-023134-y665agnh 997 2 vitro vitro FW cord-023134-y665agnh 997 3 studies study NNS cord-023134-y665agnh 997 4 revealed reveal VBD cord-023134-y665agnh 997 5 a a DT cord-023134-y665agnh 997 6 significantly significantly RB cord-023134-y665agnh 997 7 reduced reduce VBN cord-023134-y665agnh 997 8 HPC hpc NN cord-023134-y665agnh 997 9 proliferation proliferation NN cord-023134-y665agnh 997 10 and and CC cord-023134-y665agnh 997 11 suggested suggest VBD cord-023134-y665agnh 997 12 a a DT cord-023134-y665agnh 997 13 role role NN cord-023134-y665agnh 997 14 of of IN cord-023134-y665agnh 997 15 Bmi1 Bmi1 NNP cord-023134-y665agnh 997 16 in in IN cord-023134-y665agnh 997 17 differentiation differentiation NN cord-023134-y665agnh 997 18 ( ( -LRB- cord-023134-y665agnh 997 19 gene gene NN cord-023134-y665agnh 997 20 expression expression NN cord-023134-y665agnh 997 21 ) ) -RRB- cord-023134-y665agnh 997 22 of of IN cord-023134-y665agnh 997 23 HPCs hpc NNS cord-023134-y665agnh 997 24 . . . cord-023134-y665agnh 998 1 These these DT cord-023134-y665agnh 998 2 results result NNS cord-023134-y665agnh 998 3 indicate indicate VBP cord-023134-y665agnh 998 4 that that IN cord-023134-y665agnh 998 5 Bmi1 Bmi1 NNP cord-023134-y665agnh 998 6 is be VBZ cord-023134-y665agnh 998 7 expressed express VBN cord-023134-y665agnh 998 8 in in IN cord-023134-y665agnh 998 9 activated activate VBN cord-023134-y665agnh 998 10 HPCs hpc NNS cord-023134-y665agnh 998 11 in in IN cord-023134-y665agnh 998 12 all all DT cord-023134-y665agnh 998 13 liver liver NN cord-023134-y665agnh 998 14 diseases disease NNS cord-023134-y665agnh 998 15 tested test VBN cord-023134-y665agnh 998 16 . . . cord-023134-y665agnh 999 1 Bmi1 Bmi1 NNP cord-023134-y665agnh 999 2 is be VBZ cord-023134-y665agnh 999 3 needed need VBN cord-023134-y665agnh 999 4 for for IN cord-023134-y665agnh 999 5 proliferation proliferation NN cord-023134-y665agnh 999 6 of of IN cord-023134-y665agnh 999 7 HPCs hpc NNS cord-023134-y665agnh 999 8 in in IN cord-023134-y665agnh 999 9 vitro vitro FW cord-023134-y665agnh 999 10 and and CC cord-023134-y665agnh 999 11 is be VBZ cord-023134-y665agnh 999 12 potentially potentially RB cord-023134-y665agnh 999 13 involved involve VBN cord-023134-y665agnh 999 14 in in IN cord-023134-y665agnh 999 15 HPC hpc NN cord-023134-y665agnh 999 16 differentiation differentiation NN cord-023134-y665agnh 999 17 . . . cord-023134-y665agnh 1000 1 Expression expression NN cord-023134-y665agnh 1000 2 of of IN cord-023134-y665agnh 1000 3 Bmi1 Bmi1 NNP cord-023134-y665agnh 1000 4 in in IN cord-023134-y665agnh 1000 5 HCCs hccs NN cord-023134-y665agnh 1000 6 suggests suggest VBZ cord-023134-y665agnh 1000 7 a a DT cord-023134-y665agnh 1000 8 role role NN cord-023134-y665agnh 1000 9 in in IN cord-023134-y665agnh 1000 10 tumour tumour NN cord-023134-y665agnh 1000 11 development development NN cord-023134-y665agnh 1000 12 , , , cord-023134-y665agnh 1000 13 potentially potentially RB cord-023134-y665agnh 1000 14 due due JJ cord-023134-y665agnh 1000 15 to to IN cord-023134-y665agnh 1000 16 a a DT cord-023134-y665agnh 1000 17 persistent persistent JJ cord-023134-y665agnh 1000 18 activation activation NN cord-023134-y665agnh 1000 19 of of IN cord-023134-y665agnh 1000 20 HPCs hpc NNS cord-023134-y665agnh 1000 21 . . . cord-023134-y665agnh 1001 1 Therefore therefore RB cord-023134-y665agnh 1001 2 , , , cord-023134-y665agnh 1001 3 enhanced enhanced JJ cord-023134-y665agnh 1001 4 activation activation NN cord-023134-y665agnh 1001 5 of of IN cord-023134-y665agnh 1001 6 Bmi1 Bmi1 NNP cord-023134-y665agnh 1001 7 will will MD cord-023134-y665agnh 1001 8 lead lead VB cord-023134-y665agnh 1001 9 to to IN cord-023134-y665agnh 1001 10 more more JJR cord-023134-y665agnh 1001 11 progenitor progenitor NN cord-023134-y665agnh 1001 12 cells cell NNS cord-023134-y665agnh 1001 13 ( ( -LRB- cord-023134-y665agnh 1001 14 beneficial beneficial JJ cord-023134-y665agnh 1001 15 ) ) -RRB- cord-023134-y665agnh 1001 16 but but CC cord-023134-y665agnh 1001 17 most most RBS cord-023134-y665agnh 1001 18 likely likely RB cord-023134-y665agnh 1001 19 also also RB cord-023134-y665agnh 1001 20 to to IN cord-023134-y665agnh 1001 21 more more RBR cord-023134-y665agnh 1001 22 aggressive aggressive JJ cord-023134-y665agnh 1001 23 HCC HCC NNP cord-023134-y665agnh 1001 24 with with IN cord-023134-y665agnh 1001 25 a a DT cord-023134-y665agnh 1001 26 HPC hpc NN cord-023134-y665agnh 1001 27 - - HYPH cord-023134-y665agnh 1001 28 signature signature NN cord-023134-y665agnh 1001 29 . . . cord-023134-y665agnh 1002 1 Hepatic hepatic JJ cord-023134-y665agnh 1002 2 progenitor progenitor NN cord-023134-y665agnh 1002 3 cells cell NNS cord-023134-y665agnh 1002 4 ( ( -LRB- cord-023134-y665agnh 1002 5 HPC HPC NNP cord-023134-y665agnh 1002 6 ) ) -RRB- cord-023134-y665agnh 1002 7 are be VBP cord-023134-y665agnh 1002 8 bipotential bipotential NNP cord-023134-y665agnh 1002 9 , , , cord-023134-y665agnh 1002 10 forming form VBG cord-023134-y665agnh 1002 11 cholangiocytes cholangiocyte NNS cord-023134-y665agnh 1002 12 or or CC cord-023134-y665agnh 1002 13 hepatocytes hepatocyte NNS cord-023134-y665agnh 1002 14 . . . cord-023134-y665agnh 1003 1 As as IN cord-023134-y665agnh 1003 2 a a DT cord-023134-y665agnh 1003 3 result result NN cord-023134-y665agnh 1003 4 , , , cord-023134-y665agnh 1003 5 they -PRON- PRP cord-023134-y665agnh 1003 6 express express VBP cord-023134-y665agnh 1003 7 markers marker NNS cord-023134-y665agnh 1003 8 of of IN cord-023134-y665agnh 1003 9 both both DT cord-023134-y665agnh 1003 10 cell cell NN cord-023134-y665agnh 1003 11 types type NNS cord-023134-y665agnh 1003 12 . . . cord-023134-y665agnh 1004 1 Various various JJ cord-023134-y665agnh 1004 2 markers marker NNS cord-023134-y665agnh 1004 3 have have VBP cord-023134-y665agnh 1004 4 been be VBN cord-023134-y665agnh 1004 5 used use VBN cord-023134-y665agnh 1004 6 to to TO cord-023134-y665agnh 1004 7 select select VB cord-023134-y665agnh 1004 8 for for IN cord-023134-y665agnh 1004 9 HPC HPC NNP cord-023134-y665agnh 1004 10 's 's POS cord-023134-y665agnh 1004 11 yet yet RB cord-023134-y665agnh 1004 12 there there EX cord-023134-y665agnh 1004 13 is be VBZ cord-023134-y665agnh 1004 14 no no DT cord-023134-y665agnh 1004 15 specific specific JJ cord-023134-y665agnh 1004 16 cell cell NN cord-023134-y665agnh 1004 17 marker marker NN cord-023134-y665agnh 1004 18 . . . cord-023134-y665agnh 1005 1 CD133 CD133 NNP cord-023134-y665agnh 1005 2 , , , cord-023134-y665agnh 1005 3 a a DT cord-023134-y665agnh 1005 4 transmembrane transmembrane NN cord-023134-y665agnh 1005 5 glycoprotein glycoprotein NN cord-023134-y665agnh 1005 6 , , , cord-023134-y665agnh 1005 7 has have VBZ cord-023134-y665agnh 1005 8 been be VBN cord-023134-y665agnh 1005 9 identified identify VBN cord-023134-y665agnh 1005 10 as as IN cord-023134-y665agnh 1005 11 a a DT cord-023134-y665agnh 1005 12 organ organ NN cord-023134-y665agnh 1005 13 stem stem NN cord-023134-y665agnh 1005 14 cell cell NN cord-023134-y665agnh 1005 15 marker marker NN cord-023134-y665agnh 1005 16 and and CC cord-023134-y665agnh 1005 17 cancer cancer NN cord-023134-y665agnh 1005 18 stem stem NN cord-023134-y665agnh 1005 19 cell cell NN cord-023134-y665agnh 1005 20 marker marker NN cord-023134-y665agnh 1005 21 , , , cord-023134-y665agnh 1005 22 and and CC cord-023134-y665agnh 1005 23 used use VBD cord-023134-y665agnh 1005 24 to to TO cord-023134-y665agnh 1005 25 select select VB cord-023134-y665agnh 1005 26 HPC HPC NNP cord-023134-y665agnh 1005 27 's 's POS cord-023134-y665agnh 1005 28 in in IN cord-023134-y665agnh 1005 29 rodents rodent NNS cord-023134-y665agnh 1005 30 and and CC cord-023134-y665agnh 1005 31 humans human NNS cord-023134-y665agnh 1005 32 . . . cord-023134-y665agnh 1006 1 Canine canine JJ cord-023134-y665agnh 1006 2 HPC HPC NNP cord-023134-y665agnh 1006 3 have have VBP cord-023134-y665agnh 1006 4 been be VBN cord-023134-y665agnh 1006 5 shown show VBN cord-023134-y665agnh 1006 6 to to TO cord-023134-y665agnh 1006 7 have have VB cord-023134-y665agnh 1006 8 gene gene NN cord-023134-y665agnh 1006 9 expression expression NN cord-023134-y665agnh 1006 10 of of IN cord-023134-y665agnh 1006 11 CD133 CD133 NNP cord-023134-y665agnh 1006 12 . . . cord-023134-y665agnh 1007 1 This this DT cord-023134-y665agnh 1007 2 study study NN cord-023134-y665agnh 1007 3 aimed aim VBD cord-023134-y665agnh 1007 4 to to TO cord-023134-y665agnh 1007 5 assess assess VB cord-023134-y665agnh 1007 6 if if IN cord-023134-y665agnh 1007 7 CD133 CD133 NNP cord-023134-y665agnh 1007 8 selection selection NN cord-023134-y665agnh 1007 9 could could MD cord-023134-y665agnh 1007 10 enrich enrich VB cord-023134-y665agnh 1007 11 for for IN cord-023134-y665agnh 1007 12 canine canine JJ cord-023134-y665agnh 1007 13 HPCs hpc NNS cord-023134-y665agnh 1007 14 . . . cord-023134-y665agnh 1008 1 A a DT cord-023134-y665agnh 1008 2 wedge wedge NN cord-023134-y665agnh 1008 3 of of IN cord-023134-y665agnh 1008 4 liver liver NN cord-023134-y665agnh 1008 5 from from IN cord-023134-y665agnh 1008 6 a a DT cord-023134-y665agnh 1008 7 healthy healthy JJ cord-023134-y665agnh 1008 8 dog dog NN cord-023134-y665agnh 1008 9 euthanased euthanase VBN cord-023134-y665agnh 1008 10 for for IN cord-023134-y665agnh 1008 11 behavioural behavioural JJ cord-023134-y665agnh 1008 12 reasons reason NNS cord-023134-y665agnh 1008 13 was be VBD cord-023134-y665agnh 1008 14 digested digest VBN cord-023134-y665agnh 1008 15 by by IN cord-023134-y665agnh 1008 16 collagenase collagenase NNP cord-023134-y665agnh 1008 17 perfusion perfusion NN cord-023134-y665agnh 1008 18 . . . cord-023134-y665agnh 1009 1 Hepatocytes hepatocyte NNS cord-023134-y665agnh 1009 2 were be VBD cord-023134-y665agnh 1009 3 removed remove VBN cord-023134-y665agnh 1009 4 by by IN cord-023134-y665agnh 1009 5 pelleting pellete VBG cord-023134-y665agnh 1009 6 at at IN cord-023134-y665agnh 1009 7 50 50 CD cord-023134-y665agnh 1009 8 g g NN cord-023134-y665agnh 1009 9 for for IN cord-023134-y665agnh 1009 10 5 5 CD cord-023134-y665agnh 1009 11 mins min NNS cord-023134-y665agnh 1009 12 . . . cord-023134-y665agnh 1010 1 The the DT cord-023134-y665agnh 1010 2 remaining remain VBG cord-023134-y665agnh 1010 3 non non JJ cord-023134-y665agnh 1010 4 - - JJ cord-023134-y665agnh 1010 5 parenchymal parenchymal JJ cord-023134-y665agnh 1010 6 cells cell NNS cord-023134-y665agnh 1010 7 ( ( -LRB- cord-023134-y665agnh 1010 8 NPC NPC NNP cord-023134-y665agnh 1010 9 ) ) -RRB- cord-023134-y665agnh 1010 10 were be VBD cord-023134-y665agnh 1010 11 then then RB cord-023134-y665agnh 1010 12 pelleted pellete VBN cord-023134-y665agnh 1010 13 at at IN cord-023134-y665agnh 1010 14 200 200 CD cord-023134-y665agnh 1010 15 g g NN cord-023134-y665agnh 1010 16 for for IN cord-023134-y665agnh 1010 17 5 5 CD cord-023134-y665agnh 1010 18 mins min NNS cord-023134-y665agnh 1010 19 . . . cord-023134-y665agnh 1011 1 Magnetic magnetic JJ cord-023134-y665agnh 1011 2 assisted assisted JJ cord-023134-y665agnh 1011 3 cell cell NN cord-023134-y665agnh 1011 4 sorting sorting NN cord-023134-y665agnh 1011 5 ( ( -LRB- cord-023134-y665agnh 1011 6 MACS MACS NNP cord-023134-y665agnh 1011 7 ) ) -RRB- cord-023134-y665agnh 1011 8 for for IN cord-023134-y665agnh 1011 9 cells cell NNS cord-023134-y665agnh 1011 10 positive positive JJ cord-023134-y665agnh 1011 11 and and CC cord-023134-y665agnh 1011 12 negative negative JJ cord-023134-y665agnh 1011 13 for for IN cord-023134-y665agnh 1011 14 CD133 CD133 NNP cord-023134-y665agnh 1011 15 was be VBD cord-023134-y665agnh 1011 16 performed perform VBN cord-023134-y665agnh 1011 17 according accord VBG cord-023134-y665agnh 1011 18 to to IN cord-023134-y665agnh 1011 19 the the DT cord-023134-y665agnh 1011 20 manufacturer manufacturer NN cord-023134-y665agnh 1011 21 's 's POS cord-023134-y665agnh 1011 22 instructions instruction NNS cord-023134-y665agnh 1011 23 . . . cord-023134-y665agnh 1012 1 CD133 CD133 NNP cord-023134-y665agnh 1012 2 positive positive JJ cord-023134-y665agnh 1012 3 and and CC cord-023134-y665agnh 1012 4 negative negative JJ cord-023134-y665agnh 1012 5 NPC NPC NNP cord-023134-y665agnh 1012 6 were be VBD cord-023134-y665agnh 1012 7 cultured culture VBN cord-023134-y665agnh 1012 8 on on IN cord-023134-y665agnh 1012 9 bovine bovine JJ cord-023134-y665agnh 1012 10 type type NN cord-023134-y665agnh 1013 1 I -PRON- PRP cord-023134-y665agnh 1013 2 collagen collagen NN cord-023134-y665agnh 1013 3 - - HYPH cord-023134-y665agnh 1013 4 coated coat VBN cord-023134-y665agnh 1013 5 plates plate NNS cord-023134-y665agnh 1013 6 with with IN cord-023134-y665agnh 1013 7 Hepatocyte Hepatocyte NNP cord-023134-y665agnh 1013 8 culture culture NN cord-023134-y665agnh 1013 9 media medium NNS cord-023134-y665agnh 1013 10 ( ( -LRB- cord-023134-y665agnh 1013 11 Lonza Lonza NNP cord-023134-y665agnh 1013 12 ) ) -RRB- cord-023134-y665agnh 1013 13 . . . cord-023134-y665agnh 1014 1 Cell cell NN cord-023134-y665agnh 1014 2 morphology morphology NN cord-023134-y665agnh 1014 3 was be VBD cord-023134-y665agnh 1014 4 monitored monitor VBN cord-023134-y665agnh 1014 5 . . . cord-023134-y665agnh 1015 1 RNA RNA NNP cord-023134-y665agnh 1015 2 was be VBD cord-023134-y665agnh 1015 3 extracted extract VBN cord-023134-y665agnh 1015 4 and and CC cord-023134-y665agnh 1015 5 cDNA cdna NN cord-023134-y665agnh 1015 6 produced produce VBN cord-023134-y665agnh 1015 7 from from IN cord-023134-y665agnh 1015 8 cell cell NN cord-023134-y665agnh 1015 9 pellets pellet NNS cord-023134-y665agnh 1015 10 immediately immediately RB cord-023134-y665agnh 1015 11 after after IN cord-023134-y665agnh 1015 12 separation separation NN cord-023134-y665agnh 1015 13 and and CC cord-023134-y665agnh 1015 14 also also RB cord-023134-y665agnh 1015 15 after after IN cord-023134-y665agnh 1015 16 3 3 CD cord-023134-y665agnh 1015 17 weeks week NNS cord-023134-y665agnh 1015 18 of of IN cord-023134-y665agnh 1015 19 culture culture NN cord-023134-y665agnh 1015 20 . . . cord-023134-y665agnh 1016 1 Relative relative JJ cord-023134-y665agnh 1016 2 gene gene NN cord-023134-y665agnh 1016 3 expression expression NN cord-023134-y665agnh 1016 4 of of IN cord-023134-y665agnh 1016 5 CD133 CD133 NNP cord-023134-y665agnh 1016 6 , , , cord-023134-y665agnh 1016 7 cholangiocyte cholangiocyte NNP cord-023134-y665agnh 1016 8 marker marker NN cord-023134-y665agnh 1016 9 Keratin Keratin NNP cord-023134-y665agnh 1016 10 7 7 CD cord-023134-y665agnh 1016 11 ( ( -LRB- cord-023134-y665agnh 1016 12 K7 K7 NNP cord-023134-y665agnh 1016 13 ) ) -RRB- cord-023134-y665agnh 1016 14 and and CC cord-023134-y665agnh 1016 15 hepatocytes hepatocyte NNS cord-023134-y665agnh 1016 16 markers marker NNS cord-023134-y665agnh 1016 17 K18 k18 JJ cord-023134-y665agnh 1016 18 , , , cord-023134-y665agnh 1016 19 albumin albumin NN cord-023134-y665agnh 1016 20 and and CC cord-023134-y665agnh 1016 21 CYP1A1 CYP1A1 NNP cord-023134-y665agnh 1016 22 was be VBD cord-023134-y665agnh 1016 23 performed perform VBN cord-023134-y665agnh 1016 24 using use VBG cord-023134-y665agnh 1016 25 B2MG B2MG NNP cord-023134-y665agnh 1016 26 and and CC cord-023134-y665agnh 1016 27 RPL8 RPL8 NNP cord-023134-y665agnh 1016 28 as as IN cord-023134-y665agnh 1016 29 reference reference NN cord-023134-y665agnh 1016 30 genes gene NNS cord-023134-y665agnh 1016 31 . . . cord-023134-y665agnh 1017 1 The the DT cord-023134-y665agnh 1017 2 CD133 CD133 NNP cord-023134-y665agnh 1017 3 positive positive JJ cord-023134-y665agnh 1017 4 fraction fraction NN cord-023134-y665agnh 1017 5 was be VBD cord-023134-y665agnh 1017 6 38 38 CD cord-023134-y665agnh 1017 7 % % NN cord-023134-y665agnh 1017 8 of of IN cord-023134-y665agnh 1017 9 the the DT cord-023134-y665agnh 1017 10 NPCs npc NNS cord-023134-y665agnh 1017 11 . . . cord-023134-y665agnh 1018 1 Morphologically Morphologically NNP cord-023134-y665agnh 1018 2 , , , cord-023134-y665agnh 1018 3 CD133 CD133 NNP cord-023134-y665agnh 1018 4 positive positive JJ cord-023134-y665agnh 1018 5 cells cell NNS cord-023134-y665agnh 1018 6 formed form VBD cord-023134-y665agnh 1018 7 more more JJR cord-023134-y665agnh 1018 8 colonies colony NNS cord-023134-y665agnh 1018 9 of of IN cord-023134-y665agnh 1018 10 cells cell NNS cord-023134-y665agnh 1018 11 with with IN cord-023134-y665agnh 1018 12 a a DT cord-023134-y665agnh 1018 13 small small JJ cord-023134-y665agnh 1018 14 cytoplasm cytoplasm NN cord-023134-y665agnh 1018 15 to to IN cord-023134-y665agnh 1018 16 nucleus nucleus NN cord-023134-y665agnh 1018 17 ratio ratio NN cord-023134-y665agnh 1018 18 , , , cord-023134-y665agnh 1018 19 which which WDT cord-023134-y665agnh 1018 20 then then RB cord-023134-y665agnh 1018 21 transformed transform VBD cord-023134-y665agnh 1018 22 to to IN cord-023134-y665agnh 1018 23 hepatoblastic hepatoblastic JJ cord-023134-y665agnh 1018 24 appearance appearance NN cord-023134-y665agnh 1018 25 while while IN cord-023134-y665agnh 1018 26 the the DT cord-023134-y665agnh 1018 27 negative negative JJ cord-023134-y665agnh 1018 28 cells cell NNS cord-023134-y665agnh 1018 29 produced produce VBD cord-023134-y665agnh 1018 30 more more JJR cord-023134-y665agnh 1018 31 fibroblastic fibroblastic JJ cord-023134-y665agnh 1018 32 cells cell NNS cord-023134-y665agnh 1018 33 . . . cord-023134-y665agnh 1019 1 Compared compare VBN cord-023134-y665agnh 1019 2 to to IN cord-023134-y665agnh 1019 3 CD133 CD133 NNP cord-023134-y665agnh 1019 4 negative negative JJ cord-023134-y665agnh 1019 5 cells cell NNS cord-023134-y665agnh 1019 6 , , , cord-023134-y665agnh 1019 7 initially initially RB cord-023134-y665agnh 1019 8 CD133 CD133 NNP cord-023134-y665agnh 1019 9 positive positive JJ cord-023134-y665agnh 1019 10 cells cell NNS cord-023134-y665agnh 1019 11 showed show VBD cord-023134-y665agnh 1019 12 a a DT cord-023134-y665agnh 1019 13 2-fold 2-fold CD cord-023134-y665agnh 1019 14 increase increase NN cord-023134-y665agnh 1019 15 in in IN cord-023134-y665agnh 1019 16 CD133 CD133 NNP cord-023134-y665agnh 1019 17 , , , cord-023134-y665agnh 1019 18 and and CC cord-023134-y665agnh 1019 19 2.5-fold 2.5-fold CD cord-023134-y665agnh 1019 20 increase increase NN cord-023134-y665agnh 1019 21 in in IN cord-023134-y665agnh 1019 22 cholangiocyte cholangiocyte NNP cord-023134-y665agnh 1019 23 marker marker NN cord-023134-y665agnh 1019 24 K7 K7 NNP cord-023134-y665agnh 1019 25 as as RB cord-023134-y665agnh 1019 26 well well RB cord-023134-y665agnh 1019 27 as as IN cord-023134-y665agnh 1019 28 modest modest JJ cord-023134-y665agnh 1019 29 increases increase NNS cord-023134-y665agnh 1019 30 in in IN cord-023134-y665agnh 1019 31 hepatocyte hepatocyte NN cord-023134-y665agnh 1019 32 markers marker NNS cord-023134-y665agnh 1019 33 albumin albumin NN cord-023134-y665agnh 1019 34 and and CC cord-023134-y665agnh 1019 35 CYP1A1 CYP1A1 NNP cord-023134-y665agnh 1019 36 and and CC cord-023134-y665agnh 1019 37 a a DT cord-023134-y665agnh 1019 38 modest modest JJ cord-023134-y665agnh 1019 39 decrease decrease NN cord-023134-y665agnh 1019 40 in in IN cord-023134-y665agnh 1019 41 K18 K18 NNP cord-023134-y665agnh 1019 42 . . . cord-023134-y665agnh 1020 1 After after IN cord-023134-y665agnh 1020 2 3 3 CD cord-023134-y665agnh 1020 3 weeks week NNS cord-023134-y665agnh 1020 4 culture culture NN cord-023134-y665agnh 1020 5 , , , cord-023134-y665agnh 1020 6 positive positive JJ cord-023134-y665agnh 1020 7 cells cell NNS cord-023134-y665agnh 1020 8 expressed express VBD cord-023134-y665agnh 1020 9 more more JJR cord-023134-y665agnh 1020 10 albumin albumin NN cord-023134-y665agnh 1020 11 , , , cord-023134-y665agnh 1020 12 CYP1A1 CYP1A1 NNP cord-023134-y665agnh 1020 13 , , , cord-023134-y665agnh 1020 14 K7 K7 NNP cord-023134-y665agnh 1020 15 & & CC cord-023134-y665agnh 1020 16 K18 K18 NNP cord-023134-y665agnh 1020 17 compared compare VBN cord-023134-y665agnh 1020 18 to to IN cord-023134-y665agnh 1020 19 CD133 CD133 NNP cord-023134-y665agnh 1020 20 negative negative JJ cord-023134-y665agnh 1020 21 cultures culture NNS cord-023134-y665agnh 1020 22 . . . cord-023134-y665agnh 1021 1 CD133 CD133 NNP cord-023134-y665agnh 1021 2 expression expression NN cord-023134-y665agnh 1021 3 had have VBD cord-023134-y665agnh 1021 4 reduced reduce VBN cord-023134-y665agnh 1021 5 to to IN cord-023134-y665agnh 1021 6 a a DT cord-023134-y665agnh 1021 7 1fold 1fold CD cord-023134-y665agnh 1021 8 increase increase NN cord-023134-y665agnh 1021 9 after after IN cord-023134-y665agnh 1021 10 culture culture NN cord-023134-y665agnh 1021 11 . . . cord-023134-y665agnh 1022 1 The the DT cord-023134-y665agnh 1022 2 CD133 CD133 NNP cord-023134-y665agnh 1022 3 positive positive JJ cord-023134-y665agnh 1022 4 fraction fraction NN cord-023134-y665agnh 1022 5 expressed express VBD cord-023134-y665agnh 1022 6 cholangiocyte cholangiocyte NNP cord-023134-y665agnh 1022 7 and and CC cord-023134-y665agnh 1022 8 hepatocytes hepatocyte NNS cord-023134-y665agnh 1022 9 markers marker NNS cord-023134-y665agnh 1022 10 compared compare VBN cord-023134-y665agnh 1022 11 to to IN cord-023134-y665agnh 1022 12 negative negative JJ cord-023134-y665agnh 1022 13 cells cell NNS cord-023134-y665agnh 1022 14 initially initially RB cord-023134-y665agnh 1022 15 after after IN cord-023134-y665agnh 1022 16 sorting sort VBG cord-023134-y665agnh 1022 17 . . . cord-023134-y665agnh 1023 1 After after IN cord-023134-y665agnh 1023 2 3 3 CD cord-023134-y665agnh 1023 3 weeks week NNS cord-023134-y665agnh 1023 4 culture culture NN cord-023134-y665agnh 1023 5 , , , cord-023134-y665agnh 1023 6 CD133 CD133 NNP cord-023134-y665agnh 1023 7 positive positive JJ cord-023134-y665agnh 1023 8 cells cell NNS cord-023134-y665agnh 1023 9 formed form VBD cord-023134-y665agnh 1023 10 hepatocyte hepatocyte NN cord-023134-y665agnh 1023 11 - - HYPH cord-023134-y665agnh 1023 12 like like JJ cord-023134-y665agnh 1023 13 colonies colony NNS cord-023134-y665agnh 1023 14 , , , cord-023134-y665agnh 1023 15 as as RB cord-023134-y665agnh 1023 16 well well RB cord-023134-y665agnh 1023 17 as as IN cord-023134-y665agnh 1023 18 continuing continue VBG cord-023134-y665agnh 1023 19 to to TO cord-023134-y665agnh 1023 20 have have VB cord-023134-y665agnh 1023 21 greater great JJR cord-023134-y665agnh 1023 22 hepatocyte hepatocyte NN cord-023134-y665agnh 1023 23 and and CC cord-023134-y665agnh 1023 24 cholangiocyte cholangiocyte NNP cord-023134-y665agnh 1023 25 gene gene NN cord-023134-y665agnh 1023 26 expression expression NN cord-023134-y665agnh 1023 27 . . . cord-023134-y665agnh 1024 1 CD133 CD133 NNP cord-023134-y665agnh 1024 2 expression expression NN cord-023134-y665agnh 1024 3 decreased decrease VBD cord-023134-y665agnh 1024 4 , , , cord-023134-y665agnh 1024 5 consistent consistent JJ cord-023134-y665agnh 1024 6 with with IN cord-023134-y665agnh 1024 7 differentiation differentiation NN cord-023134-y665agnh 1024 8 . . . cord-023134-y665agnh 1025 1 A a DT cord-023134-y665agnh 1025 2 large large JJ cord-023134-y665agnh 1025 3 percentage percentage NN cord-023134-y665agnh 1025 4 of of IN cord-023134-y665agnh 1025 5 the the DT cord-023134-y665agnh 1025 6 NPC NPC NNP cord-023134-y665agnh 1025 7 were be VBD cord-023134-y665agnh 1025 8 positive positive JJ cord-023134-y665agnh 1025 9 for for IN cord-023134-y665agnh 1025 10 CD133 CD133 NNP cord-023134-y665agnh 1025 11 . . . cord-023134-y665agnh 1026 1 CD133 CD133 NNP cord-023134-y665agnh 1026 2 sorting sorting NN cord-023134-y665agnh 1026 3 also also RB cord-023134-y665agnh 1026 4 labels label VBZ cord-023134-y665agnh 1026 5 haematopoietic haematopoietic JJ cord-023134-y665agnh 1026 6 and and CC cord-023134-y665agnh 1026 7 mesenchymal mesenchymal JJ cord-023134-y665agnh 1026 8 stem stem NN cord-023134-y665agnh 1026 9 cells cell NNS cord-023134-y665agnh 1026 10 therefore therefore RB cord-023134-y665agnh 1026 11 subsequently subsequently RB cord-023134-y665agnh 1026 12 using use VBG cord-023134-y665agnh 1026 13 FACS FACS NNP cord-023134-y665agnh 1026 14 for for IN cord-023134-y665agnh 1026 15 other other JJ cord-023134-y665agnh 1026 16 markers marker NNS cord-023134-y665agnh 1026 17 may may MD cord-023134-y665agnh 1026 18 further further RB cord-023134-y665agnh 1026 19 enrich enrich VB cord-023134-y665agnh 1026 20 for for IN cord-023134-y665agnh 1026 21 specifically specifically RB cord-023134-y665agnh 1026 22 the the DT cord-023134-y665agnh 1026 23 HPC HPC NNP cord-023134-y665agnh 1026 24 compartment compartment NN cord-023134-y665agnh 1026 25 . . . cord-023134-y665agnh 1027 1 Until until IN cord-023134-y665agnh 1027 2 now now RB cord-023134-y665agnh 1027 3 the the DT cord-023134-y665agnh 1027 4 hepatic hepatic JJ cord-023134-y665agnh 1027 5 neoplasms neoplasm NNS cord-023134-y665agnh 1027 6 in in IN cord-023134-y665agnh 1027 7 dogs dog NNS cord-023134-y665agnh 1027 8 are be VBP cord-023134-y665agnh 1027 9 classified classify VBN cord-023134-y665agnh 1027 10 as as IN cord-023134-y665agnh 1027 11 hepatocellular hepatocellular JJ cord-023134-y665agnh 1027 12 adenomas adenoma NNS cord-023134-y665agnh 1027 13 and and CC cord-023134-y665agnh 1027 14 carcinomas carcinoma NNS cord-023134-y665agnh 1027 15 , , , cord-023134-y665agnh 1027 16 cholangiocellular cholangiocellular JJ cord-023134-y665agnh 1027 17 adenomas adenoma NNS cord-023134-y665agnh 1027 18 and and CC cord-023134-y665agnh 1027 19 carcinomas carcinoma NNS cord-023134-y665agnh 1027 20 , , , cord-023134-y665agnh 1027 21 mixed mix VBN cord-023134-y665agnh 1027 22 hepato hepato NN cord-023134-y665agnh 1027 23 - - HYPH cord-023134-y665agnh 1027 24 and and CC cord-023134-y665agnh 1027 25 cholangiocellular cholangiocellular JJ cord-023134-y665agnh 1027 26 carcinomas carcinoma NNS cord-023134-y665agnh 1027 27 and and CC cord-023134-y665agnh 1027 28 hepatic hepatic JJ cord-023134-y665agnh 1027 29 carcinoids carcinoid NNS cord-023134-y665agnh 1027 30 . . . cord-023134-y665agnh 1028 1 Over over IN cord-023134-y665agnh 1028 2 the the DT cord-023134-y665agnh 1028 3 past past JJ cord-023134-y665agnh 1028 4 decade decade NN cord-023134-y665agnh 1028 5 , , , cord-023134-y665agnh 1028 6 many many JJ cord-023134-y665agnh 1028 7 advances advance NNS cord-023134-y665agnh 1028 8 have have VBP cord-023134-y665agnh 1028 9 been be VBN cord-023134-y665agnh 1028 10 made make VBN cord-023134-y665agnh 1028 11 in in IN cord-023134-y665agnh 1028 12 the the DT cord-023134-y665agnh 1028 13 characterization characterization NN cord-023134-y665agnh 1028 14 of of IN cord-023134-y665agnh 1028 15 primary primary JJ cord-023134-y665agnh 1028 16 liver liver NN cord-023134-y665agnh 1028 17 tumours tumour NNS cord-023134-y665agnh 1028 18 in in IN cord-023134-y665agnh 1028 19 man man NN cord-023134-y665agnh 1028 20 . . . cord-023134-y665agnh 1029 1 This this DT cord-023134-y665agnh 1029 2 knowledge knowledge NN cord-023134-y665agnh 1029 3 has have VBZ cord-023134-y665agnh 1029 4 resulted result VBN cord-023134-y665agnh 1029 5 in in IN cord-023134-y665agnh 1029 6 a a DT cord-023134-y665agnh 1029 7 proposal proposal NN cord-023134-y665agnh 1029 8 for for IN cord-023134-y665agnh 1029 9 a a DT cord-023134-y665agnh 1029 10 new new JJ cord-023134-y665agnh 1029 11 morphological morphological JJ cord-023134-y665agnh 1029 12 and and CC cord-023134-y665agnh 1029 13 immunohistochemical immunohistochemical JJ cord-023134-y665agnh 1029 14 classification classification NN cord-023134-y665agnh 1029 15 of of IN cord-023134-y665agnh 1029 16 primary primary JJ cord-023134-y665agnh 1029 17 liver liver NN cord-023134-y665agnh 1029 18 tumours tumour NNS cord-023134-y665agnh 1029 19 which which WDT cord-023134-y665agnh 1029 20 facilitates facilitate VBZ cord-023134-y665agnh 1029 21 the the DT cord-023134-y665agnh 1029 22 diagnosis diagnosis NN cord-023134-y665agnh 1029 23 and and CC cord-023134-y665agnh 1029 24 categorization categorization NN cord-023134-y665agnh 1029 25 of of IN cord-023134-y665agnh 1029 26 these these DT cord-023134-y665agnh 1029 27 tumours tumour NNS cord-023134-y665agnh 1029 28 including include VBG cord-023134-y665agnh 1029 29 their -PRON- PRP$ cord-023134-y665agnh 1029 30 aggressiveness aggressiveness NN cord-023134-y665agnh 1029 31 and and CC cord-023134-y665agnh 1029 32 prognosis prognosis NN cord-023134-y665agnh 1029 33 . . . cord-023134-y665agnh 1030 1 The the DT cord-023134-y665agnh 1030 2 purpose purpose NN cord-023134-y665agnh 1030 3 of of IN cord-023134-y665agnh 1030 4 this this DT cord-023134-y665agnh 1030 5 study study NN cord-023134-y665agnh 1030 6 was be VBD cord-023134-y665agnh 1030 7 to to TO cord-023134-y665agnh 1030 8 investigate investigate VB cord-023134-y665agnh 1030 9 the the DT cord-023134-y665agnh 1030 10 presence presence NN cord-023134-y665agnh 1030 11 and and CC cord-023134-y665agnh 1030 12 relative relative JJ cord-023134-y665agnh 1030 13 incidence incidence NN cord-023134-y665agnh 1030 14 of of IN cord-023134-y665agnh 1030 15 the the DT cord-023134-y665agnh 1030 16 various various JJ cord-023134-y665agnh 1030 17 morphological morphological JJ cord-023134-y665agnh 1030 18 types type NNS cord-023134-y665agnh 1030 19 of of IN cord-023134-y665agnh 1030 20 primary primary JJ cord-023134-y665agnh 1030 21 hepatic hepatic JJ cord-023134-y665agnh 1030 22 neoplasms neoplasm NNS cord-023134-y665agnh 1030 23 in in IN cord-023134-y665agnh 1030 24 the the DT cord-023134-y665agnh 1030 25 dog dog NN cord-023134-y665agnh 1030 26 and and CC cord-023134-y665agnh 1030 27 to to TO cord-023134-y665agnh 1030 28 determine determine VB cord-023134-y665agnh 1030 29 whether whether IN cord-023134-y665agnh 1030 30 the the DT cord-023134-y665agnh 1030 31 new new JJ cord-023134-y665agnh 1030 32 human human JJ cord-023134-y665agnh 1030 33 classification classification NN cord-023134-y665agnh 1030 34 also also RB cord-023134-y665agnh 1030 35 can can MD cord-023134-y665agnh 1030 36 be be VB cord-023134-y665agnh 1030 37 applied apply VBN cord-023134-y665agnh 1030 38 to to IN cord-023134-y665agnh 1030 39 canine canine JJ cord-023134-y665agnh 1030 40 hepatic hepatic JJ cord-023134-y665agnh 1030 41 neoplasms neoplasm NNS cord-023134-y665agnh 1030 42 . . . cord-023134-y665agnh 1031 1 For for IN cord-023134-y665agnh 1031 2 this this DT cord-023134-y665agnh 1031 3 study study NN cord-023134-y665agnh 1031 4 93 93 CD cord-023134-y665agnh 1031 5 canine canine JJ cord-023134-y665agnh 1031 6 primary primary JJ cord-023134-y665agnh 1031 7 liver liver NN cord-023134-y665agnh 1031 8 tumours tumour NNS cord-023134-y665agnh 1031 9 were be VBD cord-023134-y665agnh 1031 10 examined examine VBN cord-023134-y665agnh 1031 11 histologically histologically RB cord-023134-y665agnh 1031 12 and and CC cord-023134-y665agnh 1031 13 classified classify VBN cord-023134-y665agnh 1031 14 using use VBG cord-023134-y665agnh 1031 15 several several JJ cord-023134-y665agnh 1031 16 immunohistochemical immunohistochemical JJ cord-023134-y665agnh 1031 17 markers marker NNS cord-023134-y665agnh 1031 18 including include VBG cord-023134-y665agnh 1031 19 Keratin(K)19 Keratin(K)19 NNP cord-023134-y665agnh 1031 20 ( ( -LRB- cord-023134-y665agnh 1031 21 hepatic hepatic JJ cord-023134-y665agnh 1031 22 progenitor progenitor NN cord-023134-y665agnh 1031 23 ( ( -LRB- cord-023134-y665agnh 1032 1 stem stem NN cord-023134-y665agnh 1032 2 ) ) -RRB- cord-023134-y665agnh 1032 3 cell cell NN cord-023134-y665agnh 1032 4 / / SYM cord-023134-y665agnh 1032 5 bile bile NN cord-023134-y665agnh 1032 6 duct duct NN cord-023134-y665agnh 1032 7 epithelium epithelium NN cord-023134-y665agnh 1032 8 marker marker NN cord-023134-y665agnh 1032 9 ) ) -RRB- cord-023134-y665agnh 1032 10 , , . cord-023134-y665agnh 1033 1 HepPar-1 heppar-1 CD cord-023134-y665agnh 1033 2 ( ( -LRB- cord-023134-y665agnh 1033 3 hepatocyte hepatocyte NN cord-023134-y665agnh 1033 4 marker marker NN cord-023134-y665agnh 1033 5 ) ) -RRB- cord-023134-y665agnh 1033 6 , , , cord-023134-y665agnh 1033 7 EMA EMA NNP cord-023134-y665agnh 1033 8 ( ( -LRB- cord-023134-y665agnh 1033 9 MUC1 MUC1 NNP cord-023134-y665agnh 1033 10 ; ; : cord-023134-y665agnh 1033 11 mucine mucine NN cord-023134-y665agnh 1033 12 producing produce VBG cord-023134-y665agnh 1033 13 biliary biliary JJ cord-023134-y665agnh 1033 14 epithelium epithelium NN cord-023134-y665agnh 1033 15 marker marker NN cord-023134-y665agnh 1033 16 ) ) -RRB- cord-023134-y665agnh 1033 17 , , , cord-023134-y665agnh 1033 18 pCEA pcea XX cord-023134-y665agnh 1034 1 ( ( -LRB- cord-023134-y665agnh 1034 2 canalicular canalicular NNP cord-023134-y665agnh 1034 3 , , , cord-023134-y665agnh 1034 4 ductular ductular NNP cord-023134-y665agnh 1034 5 , , , cord-023134-y665agnh 1034 6 and and CC cord-023134-y665agnh 1034 7 bile bile NN cord-023134-y665agnh 1034 8 duct duct NN cord-023134-y665agnh 1034 9 epithelium epithelium NN cord-023134-y665agnh 1034 10 marker marker NN cord-023134-y665agnh 1034 11 ) ) -RRB- cord-023134-y665agnh 1034 12 , , , cord-023134-y665agnh 1034 13 NSE NSE NNP cord-023134-y665agnh 1034 14 and and CC cord-023134-y665agnh 1034 15 Chromogranin Chromogranin NNP cord-023134-y665agnh 1034 16 - - HYPH cord-023134-y665agnh 1034 17 A A NNP cord-023134-y665agnh 1034 18 ( ( -LRB- cord-023134-y665agnh 1034 19 neuro neuro JJ cord-023134-y665agnh 1034 20 - - HYPH cord-023134-y665agnh 1034 21 endocrine endocrine JJ cord-023134-y665agnh 1034 22 markers marker NNS cord-023134-y665agnh 1034 23 ) ) -RRB- cord-023134-y665agnh 1034 24 . . . cord-023134-y665agnh 1035 1 In in IN cord-023134-y665agnh 1035 2 addition addition NN cord-023134-y665agnh 1035 3 , , , cord-023134-y665agnh 1035 4 the the DT cord-023134-y665agnh 1035 5 tumours tumour NNS cord-023134-y665agnh 1035 6 were be VBD cord-023134-y665agnh 1035 7 graded grade VBN cord-023134-y665agnh 1035 8 according accord VBG cord-023134-y665agnh 1035 9 to to IN cord-023134-y665agnh 1035 10 cellular cellular JJ cord-023134-y665agnh 1035 11 and and CC cord-023134-y665agnh 1035 12 nuclear nuclear JJ cord-023134-y665agnh 1035 13 pleiomorphism pleiomorphism NN cord-023134-y665agnh 1035 14 and and CC cord-023134-y665agnh 1035 15 mitotic mitotic JJ cord-023134-y665agnh 1035 16 index index NN cord-023134-y665agnh 1035 17 ( ( -LRB- cord-023134-y665agnh 1035 18 grade:0 grade:0 NN cord-023134-y665agnh 1035 19 - - HYPH cord-023134-y665agnh 1035 20 3 3 CD cord-023134-y665agnh 1035 21 ) ) -RRB- cord-023134-y665agnh 1035 22 and and CC cord-023134-y665agnh 1035 23 staged stage VBD cord-023134-y665agnh 1035 24 with with IN cord-023134-y665agnh 1035 25 respect respect NN cord-023134-y665agnh 1035 26 to to IN cord-023134-y665agnh 1035 27 absence absence NN cord-023134-y665agnh 1035 28 or or CC cord-023134-y665agnh 1035 29 presence presence NN cord-023134-y665agnh 1035 30 of of IN cord-023134-y665agnh 1035 31 invasive invasive JJ cord-023134-y665agnh 1035 32 growth growth NN cord-023134-y665agnh 1035 33 , , , cord-023134-y665agnh 1035 34 intrahepatic intrahepatic JJ cord-023134-y665agnh 1035 35 and/or and/or CC cord-023134-y665agnh 1035 36 distant distant JJ cord-023134-y665agnh 1035 37 metastases metastasis NNS cord-023134-y665agnh 1035 38 ( ( -LRB- cord-023134-y665agnh 1035 39 stage:0 stage:0 NN cord-023134-y665agnh 1035 40 - - HYPH cord-023134-y665agnh 1035 41 2 2 CD cord-023134-y665agnh 1035 42 ) ) -RRB- cord-023134-y665agnh 1035 43 . . . cord-023134-y665agnh 1036 1 Of of IN cord-023134-y665agnh 1036 2 the the DT cord-023134-y665agnh 1036 3 93 93 CD cord-023134-y665agnh 1036 4 primary primary JJ cord-023134-y665agnh 1036 5 liver liver NN cord-023134-y665agnh 1036 6 tumours tumour NNS cord-023134-y665agnh 1036 7 , , , cord-023134-y665agnh 1036 8 80 80 CD cord-023134-y665agnh 1036 9 had have VBD cord-023134-y665agnh 1036 10 a a DT cord-023134-y665agnh 1036 11 hepatocellular hepatocellular JJ cord-023134-y665agnh 1036 12 origin origin NN cord-023134-y665agnh 1036 13 ( ( -LRB- cord-023134-y665agnh 1036 14 86 86 CD cord-023134-y665agnh 1036 15 % % NN cord-023134-y665agnh 1036 16 ) ) -RRB- cord-023134-y665agnh 1036 17 . . . cord-023134-y665agnh 1037 1 These these DT cord-023134-y665agnh 1037 2 hepatocellular hepatocellular JJ cord-023134-y665agnh 1037 3 tumours tumour NNS cord-023134-y665agnh 1037 4 could could MD cord-023134-y665agnh 1037 5 be be VB cord-023134-y665agnh 1037 6 subdivided subdivide VBN cord-023134-y665agnh 1037 7 in in IN cord-023134-y665agnh 1037 8 hepatocellular hepatocellular JJ cord-023134-y665agnh 1037 9 tumours tumour NNS cord-023134-y665agnh 1037 10 with with IN cord-023134-y665agnh 1037 11 < < NNP cord-023134-y665agnh 1037 12 10 10 CD cord-023134-y665agnh 1037 13 % % NN cord-023134-y665agnh 1037 14 positivity positivity NN cord-023134-y665agnh 1037 15 for for IN cord-023134-y665agnh 1037 16 K19 K19 NNP cord-023134-y665agnh 1037 17 ( ( -LRB- cord-023134-y665agnh 1037 18 65 65 CD cord-023134-y665agnh 1037 19 % % NN cord-023134-y665agnh 1037 20 ) ) -RRB- cord-023134-y665agnh 1037 21 and and CC cord-023134-y665agnh 1037 22 tumours tumour NNS cord-023134-y665agnh 1037 23 with with IN cord-023134-y665agnh 1037 24 > > XX cord-023134-y665agnh 1037 25 10 10 CD cord-023134-y665agnh 1037 26 % % NN cord-023134-y665agnh 1037 27 positivity positivity NN cord-023134-y665agnh 1037 28 for for IN cord-023134-y665agnh 1037 29 K19 K19 NNP cord-023134-y665agnh 1037 30 ( ( -LRB- cord-023134-y665agnh 1037 31 22 22 CD cord-023134-y665agnh 1037 32 % % NN cord-023134-y665agnh 1037 33 ) ) -RRB- cord-023134-y665agnh 1037 34 . . . cord-023134-y665agnh 1038 1 The the DT cord-023134-y665agnh 1038 2 hepatocellular hepatocellular JJ cord-023134-y665agnh 1038 3 tumours tumour NNS cord-023134-y665agnh 1038 4 with with IN cord-023134-y665agnh 1038 5 > > XX cord-023134-y665agnh 1038 6 10 10 CD cord-023134-y665agnh 1038 7 % % NN cord-023134-y665agnh 1038 8 positivity positivity NN cord-023134-y665agnh 1038 9 for for IN cord-023134-y665agnh 1038 10 K19 K19 NNP cord-023134-y665agnh 1038 11 were be VBD cord-023134-y665agnh 1038 12 histologically histologically RB cord-023134-y665agnh 1038 13 poorly poorly RB cord-023134-y665agnh 1038 14 differentiated differentiate VBN cord-023134-y665agnh 1038 15 and and CC cord-023134-y665agnh 1038 16 often often RB cord-023134-y665agnh 1038 17 revealed reveal VBD cord-023134-y665agnh 1038 18 lymphatic lymphatic JJ cord-023134-y665agnh 1038 19 and and CC cord-023134-y665agnh 1038 20 vascular vascular JJ cord-023134-y665agnh 1038 21 invasion invasion NN cord-023134-y665agnh 1038 22 in in IN cord-023134-y665agnh 1038 23 portal portal JJ cord-023134-y665agnh 1038 24 tracts tract NNS cord-023134-y665agnh 1038 25 and and CC cord-023134-y665agnh 1038 26 all all DT cord-023134-y665agnh 1038 27 showed show VBD cord-023134-y665agnh 1038 28 intrahepatic intrahepatic JJ cord-023134-y665agnh 1038 29 and/or and/or CC cord-023134-y665agnh 1038 30 distant distant JJ cord-023134-y665agnh 1038 31 metastasis metastasis NN cord-023134-y665agnh 1038 32 . . . cord-023134-y665agnh 1039 1 In in IN cord-023134-y665agnh 1039 2 contrast contrast NN cord-023134-y665agnh 1039 3 the the DT cord-023134-y665agnh 1039 4 hepatocellular hepatocellular JJ cord-023134-y665agnh 1039 5 tumours tumour NNS cord-023134-y665agnh 1039 6 with with IN cord-023134-y665agnh 1039 7 < < NNP cord-023134-y665agnh 1039 8 10 10 CD cord-023134-y665agnh 1039 9 % % NN cord-023134-y665agnh 1039 10 positivity positivity NN cord-023134-y665agnh 1039 11 for for IN cord-023134-y665agnh 1039 12 K19 K19 NNP cord-023134-y665agnh 1039 13 were be VBD cord-023134-y665agnh 1039 14 almost almost RB cord-023134-y665agnh 1039 15 always always RB cord-023134-y665agnh 1039 16 well well RB cord-023134-y665agnh 1039 17 differentiated differentiated JJ cord-023134-y665agnh 1039 18 and and CC cord-023134-y665agnh 1039 19 well well RB cord-023134-y665agnh 1039 20 demarcated demarcated JJ cord-023134-y665agnh 1039 21 and and CC cord-023134-y665agnh 1039 22 did do VBD cord-023134-y665agnh 1039 23 not not RB cord-023134-y665agnh 1039 24 have have VB cord-023134-y665agnh 1039 25 evidence evidence NN cord-023134-y665agnh 1039 26 for for IN cord-023134-y665agnh 1039 27 vascular vascular JJ cord-023134-y665agnh 1039 28 invasion invasion NN cord-023134-y665agnh 1039 29 , , , cord-023134-y665agnh 1039 30 intrahepatic intrahepatic JJ cord-023134-y665agnh 1039 31 and/or and/or CC cord-023134-y665agnh 1039 32 distant distant JJ cord-023134-y665agnh 1039 33 metastasis metastasis NN cord-023134-y665agnh 1039 34 . . . cord-023134-y665agnh 1040 1 Eight eight CD cord-023134-y665agnh 1040 2 of of IN cord-023134-y665agnh 1040 3 the the DT cord-023134-y665agnh 1040 4 93 93 CD cord-023134-y665agnh 1040 5 tumours tumour NNS cord-023134-y665agnh 1040 6 were be VBD cord-023134-y665agnh 1040 7 from from IN cord-023134-y665agnh 1040 8 cholangiocellular cholangiocellular JJ cord-023134-y665agnh 1040 9 origin origin NN cord-023134-y665agnh 1040 10 ( ( -LRB- cord-023134-y665agnh 1040 11 9 9 CD cord-023134-y665agnh 1040 12 % % NN cord-023134-y665agnh 1040 13 ) ) -RRB- cord-023134-y665agnh 1040 14 . . . cord-023134-y665agnh 1041 1 All all DT cord-023134-y665agnh 1041 2 of of IN cord-023134-y665agnh 1041 3 the the DT cord-023134-y665agnh 1041 4 cholangiocellular cholangiocellular JJ cord-023134-y665agnh 1041 5 tumours tumour NNS cord-023134-y665agnh 1041 6 were be VBD cord-023134-y665agnh 1041 7 poorly poorly RB cord-023134-y665agnh 1041 8 differentiated differentiate VBN cord-023134-y665agnh 1041 9 ( ( -LRB- cord-023134-y665agnh 1041 10 grade grade NN cord-023134-y665agnh 1041 11 2 2 CD cord-023134-y665agnh 1041 12 and and CC cord-023134-y665agnh 1041 13 3 3 CD cord-023134-y665agnh 1041 14 ) ) -RRB- cord-023134-y665agnh 1041 15 and and CC cord-023134-y665agnh 1041 16 showed show VBD cord-023134-y665agnh 1041 17 intrahepatic intrahepatic JJ cord-023134-y665agnh 1041 18 and/or and/or CC cord-023134-y665agnh 1041 19 distant distant JJ cord-023134-y665agnh 1041 20 metastases metastasis NNS cord-023134-y665agnh 1041 21 . . . cord-023134-y665agnh 1042 1 The the DT cord-023134-y665agnh 1042 2 third third JJ cord-023134-y665agnh 1042 3 group group NN cord-023134-y665agnh 1042 4 of of IN cord-023134-y665agnh 1042 5 primary primary JJ cord-023134-y665agnh 1042 6 liver liver NN cord-023134-y665agnh 1042 7 tumours tumour NNS cord-023134-y665agnh 1042 8 had have VBD cord-023134-y665agnh 1042 9 neuroendocrine neuroendocrine JJ cord-023134-y665agnh 1042 10 characteristics characteristic NNS cord-023134-y665agnh 1042 11 , , , cord-023134-y665agnh 1042 12 consisted consist VBD cord-023134-y665agnh 1042 13 of of IN cord-023134-y665agnh 1042 14 five five CD cord-023134-y665agnh 1042 15 tumours tumour NNS cord-023134-y665agnh 1042 16 ( ( -LRB- cord-023134-y665agnh 1042 17 5 5 CD cord-023134-y665agnh 1042 18 % % NN cord-023134-y665agnh 1042 19 ) ) -RRB- cord-023134-y665agnh 1042 20 and and CC cord-023134-y665agnh 1042 21 were be VBD cord-023134-y665agnh 1042 22 classified classify VBN cord-023134-y665agnh 1042 23 as as IN cord-023134-y665agnh 1042 24 carcinoids carcinoid NNS cord-023134-y665agnh 1042 25 . . . cord-023134-y665agnh 1043 1 They -PRON- PRP cord-023134-y665agnh 1043 2 all all DT cord-023134-y665agnh 1043 3 were be VBD cord-023134-y665agnh 1043 4 histologically histologically RB cord-023134-y665agnh 1043 5 poorly poorly RB cord-023134-y665agnh 1043 6 differentiated differentiate VBN cord-023134-y665agnh 1043 7 and and CC cord-023134-y665agnh 1043 8 had have VBD cord-023134-y665agnh 1043 9 intrahepatic intrahepatic VBN cord-023134-y665agnh 1043 10 and/or and/or CC cord-023134-y665agnh 1043 11 distant distant JJ cord-023134-y665agnh 1043 12 metastases metastasis NNS cord-023134-y665agnh 1043 13 . . . cord-023134-y665agnh 1044 1 In in IN cord-023134-y665agnh 1044 2 conclusion conclusion NN cord-023134-y665agnh 1044 3 , , , cord-023134-y665agnh 1044 4 the the DT cord-023134-y665agnh 1044 5 morphological morphological JJ cord-023134-y665agnh 1044 6 types type NNS cord-023134-y665agnh 1044 7 of of IN cord-023134-y665agnh 1044 8 the the DT cord-023134-y665agnh 1044 9 primary primary JJ cord-023134-y665agnh 1044 10 hepatic hepatic JJ cord-023134-y665agnh 1044 11 neoplasm neoplasm NN cord-023134-y665agnh 1044 12 in in IN cord-023134-y665agnh 1044 13 the the DT cord-023134-y665agnh 1044 14 dog dog NN cord-023134-y665agnh 1044 15 , , , cord-023134-y665agnh 1044 16 including include VBG cord-023134-y665agnh 1044 17 their -PRON- PRP$ cord-023134-y665agnh 1044 18 aggressiveness aggressiveness NN cord-023134-y665agnh 1044 19 and and CC cord-023134-y665agnh 1044 20 prognosis prognosis NN cord-023134-y665agnh 1044 21 , , , cord-023134-y665agnh 1044 22 are be VBP cord-023134-y665agnh 1044 23 highly highly RB cord-023134-y665agnh 1044 24 comparable comparable JJ cord-023134-y665agnh 1044 25 to to IN cord-023134-y665agnh 1044 26 the the DT cord-023134-y665agnh 1044 27 situation situation NN cord-023134-y665agnh 1044 28 in in IN cord-023134-y665agnh 1044 29 man man NN cord-023134-y665agnh 1044 30 . . . cord-023134-y665agnh 1045 1 These these DT cord-023134-y665agnh 1045 2 finding finding NN cord-023134-y665agnh 1045 3 indicate indicate VBP cord-023134-y665agnh 1045 4 that that IN cord-023134-y665agnh 1045 5 the the DT cord-023134-y665agnh 1045 6 new new JJ cord-023134-y665agnh 1045 7 human human JJ cord-023134-y665agnh 1045 8 classification classification NN cord-023134-y665agnh 1045 9 of of IN cord-023134-y665agnh 1045 10 primary primary JJ cord-023134-y665agnh 1045 11 hepatic hepatic JJ cord-023134-y665agnh 1045 12 neoplasms neoplasm NNS cord-023134-y665agnh 1045 13 is be VBZ cord-023134-y665agnh 1045 14 applicable applicable JJ cord-023134-y665agnh 1045 15 in in IN cord-023134-y665agnh 1045 16 the the DT cord-023134-y665agnh 1045 17 dog dog NN cord-023134-y665agnh 1045 18 . . . cord-023134-y665agnh 1046 1 Doberman Doberman NNP cord-023134-y665agnh 1046 2 hepatitis hepatitis NN cord-023134-y665agnh 1046 3 ( ( -LRB- cord-023134-y665agnh 1046 4 DH DH NNP cord-023134-y665agnh 1046 5 ) ) -RRB- cord-023134-y665agnh 1046 6 is be VBZ cord-023134-y665agnh 1046 7 a a DT cord-023134-y665agnh 1046 8 rare rare JJ cord-023134-y665agnh 1046 9 inflammatory inflammatory JJ cord-023134-y665agnh 1046 10 liver liver NN cord-023134-y665agnh 1046 11 disease disease NN cord-023134-y665agnh 1046 12 characterized characterize VBN cord-023134-y665agnh 1046 13 by by IN cord-023134-y665agnh 1046 14 female female JJ cord-023134-y665agnh 1046 15 preponderance preponderance NN cord-023134-y665agnh 1046 16 , , , cord-023134-y665agnh 1046 17 elevated elevated JJ cord-023134-y665agnh 1046 18 serum serum NN cord-023134-y665agnh 1046 19 transaminase transaminase NN cord-023134-y665agnh 1046 20 activity activity NN cord-023134-y665agnh 1046 21 and and CC cord-023134-y665agnh 1046 22 increased increase VBN cord-023134-y665agnh 1046 23 hepatic hepatic JJ cord-023134-y665agnh 1046 24 copper copper NN cord-023134-y665agnh 1046 25 content content NN cord-023134-y665agnh 1046 26 . . . cord-023134-y665agnh 1047 1 Immune immune JJ cord-023134-y665agnh 1047 2 system system NN cord-023134-y665agnh 1047 3 involvement involvement NN cord-023134-y665agnh 1047 4 is be VBZ cord-023134-y665agnh 1047 5 suggested suggest VBN cord-023134-y665agnh 1047 6 by by IN cord-023134-y665agnh 1047 7 the the DT cord-023134-y665agnh 1047 8 presence presence NN cord-023134-y665agnh 1047 9 of of IN cord-023134-y665agnh 1047 10 lymphocyte lymphocyte NN cord-023134-y665agnh 1047 11 infiltration infiltration NN cord-023134-y665agnh 1047 12 , , , cord-023134-y665agnh 1047 13 female female JJ cord-023134-y665agnh 1047 14 predisposition predisposition NN cord-023134-y665agnh 1047 15 , , , cord-023134-y665agnh 1047 16 abnormal abnormal JJ cord-023134-y665agnh 1047 17 expression expression NN cord-023134-y665agnh 1047 18 of of IN cord-023134-y665agnh 1047 19 major major JJ cord-023134-y665agnh 1047 20 histocompatibility histocompatibility NN cord-023134-y665agnh 1047 21 complex complex NN cord-023134-y665agnh 1047 22 ( ( -LRB- cord-023134-y665agnh 1047 23 MHC MHC NNP cord-023134-y665agnh 1047 24 ) ) -RRB- cord-023134-y665agnh 1047 25 class class NN cord-023134-y665agnh 1047 26 II ii CD cord-023134-y665agnh 1047 27 antigens antigen NNS cord-023134-y665agnh 1047 28 by by IN cord-023134-y665agnh 1047 29 hepatocytes hepatocyte NNS cord-023134-y665agnh 1047 30 and and CC cord-023134-y665agnh 1047 31 association association NN cord-023134-y665agnh 1047 32 of of IN cord-023134-y665agnh 1047 33 homozygosity homozygosity NNP cord-023134-y665agnh 1047 34 for for IN cord-023134-y665agnh 1047 35 the the DT cord-023134-y665agnh 1047 36 MHC MHC NNP cord-023134-y665agnh 1047 37 II II NNP cord-023134-y665agnh 1047 38 risk risk NN cord-023134-y665agnh 1047 39 allele allele NN cord-023134-y665agnh 1047 40 DRB1 DRB1 NNP cord-023134-y665agnh 1048 1 * * NFP cord-023134-y665agnh 1048 2 00601 00601 CD cord-023134-y665agnh 1048 3 of of IN cord-023134-y665agnh 1048 4 the the DT cord-023134-y665agnh 1048 5 dog dog NN cord-023134-y665agnh 1048 6 leukocyte leukocyte NN cord-023134-y665agnh 1048 7 antigen antigen NN cord-023134-y665agnh 1048 8 system system NN cord-023134-y665agnh 1048 9 genotype genotype NN cord-023134-y665agnh 1048 10 . . . cord-023134-y665agnh 1049 1 We -PRON- PRP cord-023134-y665agnh 1049 2 investigated investigate VBD cord-023134-y665agnh 1049 3 the the DT cord-023134-y665agnh 1049 4 possibility possibility NN cord-023134-y665agnh 1049 5 that that IN cord-023134-y665agnh 1049 6 autoantibodies autoantibody NNS cord-023134-y665agnh 1049 7 are be VBP cord-023134-y665agnh 1049 8 involved involve VBN cord-023134-y665agnh 1049 9 in in IN cord-023134-y665agnh 1049 10 DH DH NNP cord-023134-y665agnh 1049 11 . . . cord-023134-y665agnh 1050 1 Serum serum NN cord-023134-y665agnh 1050 2 samples sample NNS cord-023134-y665agnh 1050 3 from from IN cord-023134-y665agnh 1050 4 25 25 CD cord-023134-y665agnh 1050 5 subclinical subclinical JJ cord-023134-y665agnh 1050 6 and and CC cord-023134-y665agnh 1050 7 13 13 CD cord-023134-y665agnh 1050 8 clinical clinical JJ cord-023134-y665agnh 1050 9 DH DH NNP cord-023134-y665agnh 1050 10 patients patient NNS cord-023134-y665agnh 1050 11 and and CC cord-023134-y665agnh 1050 12 17 17 CD cord-023134-y665agnh 1050 13 clinically clinically RB cord-023134-y665agnh 1050 14 healthy healthy JJ cord-023134-y665agnh 1050 15 control control NN cord-023134-y665agnh 1050 16 Dobermans Dobermans NNPS cord-023134-y665agnh 1050 17 were be VBD cord-023134-y665agnh 1050 18 included include VBN cord-023134-y665agnh 1050 19 in in IN cord-023134-y665agnh 1050 20 an an DT cord-023134-y665agnh 1050 21 ELISA ELISA NNP cord-023134-y665agnh 1050 22 assay assay NN cord-023134-y665agnh 1050 23 for for IN cord-023134-y665agnh 1050 24 detection detection NN cord-023134-y665agnh 1050 25 of of IN cord-023134-y665agnh 1050 26 IgG IgG NNP cord-023134-y665agnh 1050 27 autoantibodies autoantibody NNS cord-023134-y665agnh 1050 28 against against IN cord-023134-y665agnh 1050 29 histones histone NNS cord-023134-y665agnh 1050 30 ( ( -LRB- cord-023134-y665agnh 1050 31 AHA aha UH cord-023134-y665agnh 1050 32 ) ) -RRB- cord-023134-y665agnh 1050 33 . . . cord-023134-y665agnh 1051 1 The the DT cord-023134-y665agnh 1051 2 cut cut VB cord-023134-y665agnh 1051 3 - - HYPH cord-023134-y665agnh 1051 4 off off RP cord-023134-y665agnh 1051 5 value value NN cord-023134-y665agnh 1051 6 for for IN cord-023134-y665agnh 1051 7 positivity positivity NN cord-023134-y665agnh 1051 8 in in IN cord-023134-y665agnh 1051 9 the the DT cord-023134-y665agnh 1051 10 anti anti JJ cord-023134-y665agnh 1051 11 - - JJ cord-023134-y665agnh 1051 12 histone histone JJ cord-023134-y665agnh 1051 13 ELISA ELISA NNP cord-023134-y665agnh 1051 14 was be VBD cord-023134-y665agnh 1051 15 0.87 0.87 CD cord-023134-y665agnh 1051 16 , , , cord-023134-y665agnh 1051 17 determined determine VBN cord-023134-y665agnh 1051 18 using use VBG cord-023134-y665agnh 1051 19 the the DT cord-023134-y665agnh 1051 20 mean mean JJ cord-023134-y665agnh 1051 21 absorbance absorbance NN cord-023134-y665agnh 1051 22 +2 +2 HYPH cord-023134-y665agnh 1051 23 SD sd NN cord-023134-y665agnh 1051 24 of of IN cord-023134-y665agnh 1051 25 samples sample NNS cord-023134-y665agnh 1051 26 from from IN cord-023134-y665agnh 1051 27 healthy healthy JJ cord-023134-y665agnh 1051 28 controls control NNS cord-023134-y665agnh 1051 29 . . . cord-023134-y665agnh 1052 1 The the DT cord-023134-y665agnh 1052 2 values value NNS cord-023134-y665agnh 1052 3 for for IN cord-023134-y665agnh 1052 4 subclinical subclinical JJ cord-023134-y665agnh 1052 5 DH dh NN cord-023134-y665agnh 1052 6 cases case NNS cord-023134-y665agnh 1052 7 ( ( -LRB- cord-023134-y665agnh 1052 8 mean mean VB cord-023134-y665agnh 1052 9 ± ± NNP cord-023134-y665agnh 1052 10 SD:1.36 SD:1.36 NNP cord-023134-y665agnh 1052 11 ± ± NNP cord-023134-y665agnh 1052 12 0.6 0.6 CD cord-023134-y665agnh 1052 13 ; ; : cord-023134-y665agnh 1052 14 95 95 CD cord-023134-y665agnh 1052 15 % % NN cord-023134-y665agnh 1052 16 confidence confidence NN cord-023134-y665agnh 1052 17 interval interval NN cord-023134-y665agnh 1052 18 ( ( -LRB- cord-023134-y665agnh 1052 19 CI CI NNP cord-023134-y665agnh 1052 20 ) ) -RRB- cord-023134-y665agnh 1052 21 1.11 1.11 CD cord-023134-y665agnh 1052 22 to to TO cord-023134-y665agnh 1052 23 1.61 1.61 CD cord-023134-y665agnh 1052 24 ) ) -RRB- cord-023134-y665agnh 1052 25 and and CC cord-023134-y665agnh 1052 26 clinical clinical JJ cord-023134-y665agnh 1052 27 DH dh NN cord-023134-y665agnh 1052 28 cases case NNS cord-023134-y665agnh 1053 1 ( ( -LRB- cord-023134-y665agnh 1053 2 mean mean VB cord-023134-y665agnh 1053 3 ± ± NNP cord-023134-y665agnh 1053 4 SD:1.46 SD:1.46 NNP cord-023134-y665agnh 1053 5 ± ± NNP cord-023134-y665agnh 1053 6 0.49 0.49 CD cord-023134-y665agnh 1053 7 ; ; : cord-023134-y665agnh 1053 8 95%CI 95%ci CD cord-023134-y665agnh 1053 9 1.17 1.17 CD cord-023134-y665agnh 1053 10 to to IN cord-023134-y665agnh 1053 11 1.76 1.76 CD cord-023134-y665agnh 1053 12 ) ) -RRB- cord-023134-y665agnh 1053 13 were be VBD cord-023134-y665agnh 1053 14 both both DT cord-023134-y665agnh 1053 15 significantly significantly RB cord-023134-y665agnh 1053 16 higher high JJR cord-023134-y665agnh 1053 17 than than IN cord-023134-y665agnh 1053 18 values value NNS cord-023134-y665agnh 1053 19 for for IN cord-023134-y665agnh 1053 20 controls control NNS cord-023134-y665agnh 1053 21 ( ( -LRB- cord-023134-y665agnh 1053 22 mean mean VB cord-023134-y665agnh 1054 1 ± ± NNP cord-023134-y665agnh 1054 2 SD:0.51 SD:0.51 NNP cord-023134-y665agnh 1054 3 ± ± NNP cord-023134-y665agnh 1054 4 0.18 0.18 CD cord-023134-y665agnh 1054 5 ; ; . cord-023134-y665agnh 1055 1 95%CI 95%ci CD cord-023134-y665agnh 1055 2 0.42 0.42 CD cord-023134-y665agnh 1055 3 to to IN cord-023134-y665agnh 1055 4 0.6 0.6 CD cord-023134-y665agnh 1055 5 ; ; : cord-023134-y665agnh 1055 6 p<0.05 p<0.05 CD cord-023134-y665agnh 1055 7 ) ) -RRB- cord-023134-y665agnh 1055 8 . . . cord-023134-y665agnh 1056 1 No no DT cord-023134-y665agnh 1056 2 seropositivity seropositivity NN cord-023134-y665agnh 1056 3 was be VBD cord-023134-y665agnh 1056 4 noted note VBN cord-023134-y665agnh 1056 5 in in IN cord-023134-y665agnh 1056 6 the the DT cord-023134-y665agnh 1056 7 control control NN cord-023134-y665agnh 1056 8 group group NN cord-023134-y665agnh 1056 9 . . . cord-023134-y665agnh 1057 1 Autoantibodies autoantibody NNS cord-023134-y665agnh 1057 2 are be VBP cord-023134-y665agnh 1057 3 the the DT cord-023134-y665agnh 1057 4 serological serological JJ cord-023134-y665agnh 1057 5 hallmark hallmark NN cord-023134-y665agnh 1057 6 of of IN cord-023134-y665agnh 1057 7 autoimmune autoimmune JJ cord-023134-y665agnh 1057 8 disease disease NN cord-023134-y665agnh 1057 9 . . . cord-023134-y665agnh 1058 1 Normally normally RB cord-023134-y665agnh 1058 2 , , , cord-023134-y665agnh 1058 3 the the DT cord-023134-y665agnh 1058 4 immune immune JJ cord-023134-y665agnh 1058 5 system system NN cord-023134-y665agnh 1058 6 has have VBZ cord-023134-y665agnh 1058 7 an an DT cord-023134-y665agnh 1058 8 extraordinary extraordinary JJ cord-023134-y665agnh 1058 9 capacity capacity NN cord-023134-y665agnh 1058 10 for for IN cord-023134-y665agnh 1058 11 preventing prevent VBG cord-023134-y665agnh 1058 12 self self NN cord-023134-y665agnh 1058 13 - - HYPH cord-023134-y665agnh 1058 14 antigens antigen NNS cord-023134-y665agnh 1058 15 to to TO cord-023134-y665agnh 1058 16 stimulate stimulate VB cord-023134-y665agnh 1058 17 an an DT cord-023134-y665agnh 1058 18 inflammatory inflammatory JJ cord-023134-y665agnh 1058 19 reaction reaction NN cord-023134-y665agnh 1058 20 . . . cord-023134-y665agnh 1059 1 The the DT cord-023134-y665agnh 1059 2 presence presence NN cord-023134-y665agnh 1059 3 of of IN cord-023134-y665agnh 1059 4 autoantibodies autoantibody NNS cord-023134-y665agnh 1059 5 is be VBZ cord-023134-y665agnh 1059 6 therefore therefore RB cord-023134-y665agnh 1059 7 the the DT cord-023134-y665agnh 1059 8 consequence consequence NN cord-023134-y665agnh 1059 9 of of IN cord-023134-y665agnh 1059 10 a a DT cord-023134-y665agnh 1059 11 breakdown breakdown NN cord-023134-y665agnh 1059 12 or or CC cord-023134-y665agnh 1059 13 failure failure NN cord-023134-y665agnh 1059 14 of of IN cord-023134-y665agnh 1059 15 B b NN cord-023134-y665agnh 1059 16 - - HYPH cord-023134-y665agnh 1059 17 cell cell NN cord-023134-y665agnh 1059 18 tolerance tolerance NN cord-023134-y665agnh 1059 19 toward toward IN cord-023134-y665agnh 1059 20 the the DT cord-023134-y665agnh 1059 21 corresponding correspond VBG cord-023134-y665agnh 1059 22 autoantigens autoantigen NNS cord-023134-y665agnh 1059 23 . . . cord-023134-y665agnh 1060 1 Since since IN cord-023134-y665agnh 1060 2 the the DT cord-023134-y665agnh 1060 3 appearance appearance NN cord-023134-y665agnh 1060 4 of of IN cord-023134-y665agnh 1060 5 AHA AHA NNP cord-023134-y665agnh 1060 6 indicates indicate VBZ cord-023134-y665agnh 1060 7 possible possible JJ cord-023134-y665agnh 1060 8 presence presence NN cord-023134-y665agnh 1060 9 of of IN cord-023134-y665agnh 1060 10 autoimmunity autoimmunity NN cord-023134-y665agnh 1060 11 , , , cord-023134-y665agnh 1060 12 our -PRON- PRP$ cord-023134-y665agnh 1060 13 results result NNS cord-023134-y665agnh 1060 14 support support VBP cord-023134-y665agnh 1060 15 the the DT cord-023134-y665agnh 1060 16 assumption assumption NN cord-023134-y665agnh 1060 17 that that IN cord-023134-y665agnh 1060 18 DH DH NNP cord-023134-y665agnh 1060 19 is be VBZ cord-023134-y665agnh 1060 20 an an DT cord-023134-y665agnh 1060 21 autoimmune autoimmune JJ cord-023134-y665agnh 1060 22 disease disease NN cord-023134-y665agnh 1060 23 . . . cord-023134-y665agnh 1061 1 Man Man NNP cord-023134-y665agnh 1061 2 's 's POS cord-023134-y665agnh 1061 3 best good JJS cord-023134-y665agnh 1061 4 friend friend NN cord-023134-y665agnh 1061 5 ( ( -LRB- cord-023134-y665agnh 1061 6 Canis Canis NNP cord-023134-y665agnh 1061 7 lupus lupus NN cord-023134-y665agnh 1061 8 familiaris familiaris NN cord-023134-y665agnh 1061 9 ) ) -RRB- cord-023134-y665agnh 1061 10 is be VBZ cord-023134-y665agnh 1061 11 an an DT cord-023134-y665agnh 1061 12 ideal ideal JJ cord-023134-y665agnh 1061 13 model model NN cord-023134-y665agnh 1061 14 organism organism NN cord-023134-y665agnh 1061 15 for for IN cord-023134-y665agnh 1061 16 a a DT cord-023134-y665agnh 1061 17 broad broad JJ cord-023134-y665agnh 1061 18 variety variety NN cord-023134-y665agnh 1061 19 of of IN cord-023134-y665agnh 1061 20 naturally naturally RB cord-023134-y665agnh 1061 21 occurring occur VBG cord-023134-y665agnh 1061 22 diseases disease NNS cord-023134-y665agnh 1061 23 . . . cord-023134-y665agnh 1062 1 Dog dog NN cord-023134-y665agnh 1062 2 breeds breed NNS cord-023134-y665agnh 1062 3 have have VBP cord-023134-y665agnh 1062 4 a a DT cord-023134-y665agnh 1062 5 population population NN cord-023134-y665agnh 1062 6 structure structure NN cord-023134-y665agnh 1062 7 suited suit VBN cord-023134-y665agnh 1062 8 for for IN cord-023134-y665agnh 1062 9 genetic genetic JJ cord-023134-y665agnh 1062 10 studies study NNS cord-023134-y665agnh 1062 11 of of IN cord-023134-y665agnh 1062 12 complex complex JJ cord-023134-y665agnh 1062 13 disorders disorder NNS cord-023134-y665agnh 1062 14 . . . cord-023134-y665agnh 1063 1 Haploblocks Haploblocks NNP cord-023134-y665agnh 1063 2 within within IN cord-023134-y665agnh 1063 3 dog dog NN cord-023134-y665agnh 1063 4 breeds breed NNS cord-023134-y665agnh 1063 5 extend extend VBP cord-023134-y665agnh 1063 6 up up RP cord-023134-y665agnh 1063 7 to100 to100 NNS cord-023134-y665agnh 1063 8 times time NNS cord-023134-y665agnh 1063 9 longer long JJR cord-023134-y665agnh 1063 10 distances distance NNS cord-023134-y665agnh 1063 11 than than IN cord-023134-y665agnh 1063 12 in in IN cord-023134-y665agnh 1063 13 human human JJ cord-023134-y665agnh 1063 14 populations population NNS cord-023134-y665agnh 1063 15 . . . cord-023134-y665agnh 1064 1 Related related JJ cord-023134-y665agnh 1064 2 dog dog NN cord-023134-y665agnh 1064 3 breeds breed NNS cord-023134-y665agnh 1064 4 often often RB cord-023134-y665agnh 1064 5 share share VBP cord-023134-y665agnh 1064 6 phenotypes phenotype NNS cord-023134-y665agnh 1064 7 and and CC cord-023134-y665agnh 1064 8 causative causative JJ cord-023134-y665agnh 1064 9 mutations mutation NNS cord-023134-y665agnh 1064 10 , , , cord-023134-y665agnh 1064 11 allowing allow VBG cord-023134-y665agnh 1064 12 for for IN cord-023134-y665agnh 1064 13 finemapping finemapping NN cord-023134-y665agnh 1064 14 and and CC cord-023134-y665agnh 1064 15 validation validation NN cord-023134-y665agnh 1064 16 . . . cord-023134-y665agnh 1065 1 The the DT cord-023134-y665agnh 1065 2 inbreeding inbreeding NN cord-023134-y665agnh 1065 3 and and CC cord-023134-y665agnh 1065 4 bot bot NN cord-023134-y665agnh 1065 5 - - HYPH cord-023134-y665agnh 1065 6 tlenecks tleneck NNS cord-023134-y665agnh 1065 7 of of IN cord-023134-y665agnh 1065 8 dog dog NN cord-023134-y665agnh 1065 9 populations population NNS cord-023134-y665agnh 1065 10 has have VBZ cord-023134-y665agnh 1065 11 led lead VBN cord-023134-y665agnh 1065 12 to to IN cord-023134-y665agnh 1065 13 an an DT cord-023134-y665agnh 1065 14 increased increase VBN cord-023134-y665agnh 1065 15 incidence incidence NN cord-023134-y665agnh 1065 16 of of IN cord-023134-y665agnh 1065 17 genetic genetic JJ cord-023134-y665agnh 1065 18 diseases disease NNS cord-023134-y665agnh 1065 19 which which WDT cord-023134-y665agnh 1065 20 remained remain VBD cord-023134-y665agnh 1065 21 incidental incidental JJ cord-023134-y665agnh 1065 22 in in IN cord-023134-y665agnh 1065 23 the the DT cord-023134-y665agnh 1065 24 panmictic panmictic JJ cord-023134-y665agnh 1065 25 human human JJ cord-023134-y665agnh 1065 26 populations population NNS cord-023134-y665agnh 1065 27 . . . cord-023134-y665agnh 1066 1 Extrahepatic extrahepatic JJ cord-023134-y665agnh 1066 2 portosystemic portosystemic JJ cord-023134-y665agnh 1066 3 shunts shunt NNS cord-023134-y665agnh 1066 4 ( ( -LRB- cord-023134-y665agnh 1066 5 EHPSS EHPSS NNP cord-023134-y665agnh 1066 6 ) ) -RRB- cord-023134-y665agnh 1066 7 are be VBP cord-023134-y665agnh 1066 8 large large JJ cord-023134-y665agnh 1066 9 abnormal abnormal JJ cord-023134-y665agnh 1066 10 venous venous JJ cord-023134-y665agnh 1066 11 blood blood NN cord-023134-y665agnh 1066 12 vessels vessel NNS cord-023134-y665agnh 1066 13 connecting connect VBG cord-023134-y665agnh 1066 14 the the DT cord-023134-y665agnh 1066 15 portal portal JJ cord-023134-y665agnh 1066 16 vein vein NN cord-023134-y665agnh 1066 17 with with IN cord-023134-y665agnh 1066 18 a a DT cord-023134-y665agnh 1066 19 major major JJ cord-023134-y665agnh 1066 20 systemic systemic JJ cord-023134-y665agnh 1066 21 vein vein NN cord-023134-y665agnh 1066 22 . . . cord-023134-y665agnh 1067 1 It -PRON- PRP cord-023134-y665agnh 1067 2 results result VBZ cord-023134-y665agnh 1067 3 in in IN cord-023134-y665agnh 1067 4 almost almost RB cord-023134-y665agnh 1067 5 complete complete JJ cord-023134-y665agnh 1067 6 diversion diversion NN cord-023134-y665agnh 1067 7 of of IN cord-023134-y665agnh 1067 8 the the DT cord-023134-y665agnh 1067 9 portal portal JJ cord-023134-y665agnh 1067 10 blood blood NN cord-023134-y665agnh 1067 11 past past IN cord-023134-y665agnh 1067 12 the the DT cord-023134-y665agnh 1067 13 liver liver NN cord-023134-y665agnh 1067 14 , , , cord-023134-y665agnh 1067 15 leading lead VBG cord-023134-y665agnh 1067 16 to to IN cord-023134-y665agnh 1067 17 lack lack NN cord-023134-y665agnh 1067 18 of of IN cord-023134-y665agnh 1067 19 liver liver NN cord-023134-y665agnh 1067 20 function function NN cord-023134-y665agnh 1067 21 and and CC cord-023134-y665agnh 1067 22 liver liver NN cord-023134-y665agnh 1067 23 growth growth NN cord-023134-y665agnh 1067 24 , , , cord-023134-y665agnh 1067 25 and and CC cord-023134-y665agnh 1067 26 hepatic hepatic JJ cord-023134-y665agnh 1067 27 encephalopathy encephalopathy NN cord-023134-y665agnh 1067 28 due due IN cord-023134-y665agnh 1067 29 to to IN cord-023134-y665agnh 1067 30 brain brain NN cord-023134-y665agnh 1067 31 neurotransmitter neurotransmitter NN cord-023134-y665agnh 1067 32 dysfunctions dysfunction NNS cord-023134-y665agnh 1067 33 . . . cord-023134-y665agnh 1068 1 There there EX cord-023134-y665agnh 1068 2 are be VBP cord-023134-y665agnh 1068 3 only only RB cord-023134-y665agnh 1068 4 173 173 CD cord-023134-y665agnh 1068 5 reported report VBN cord-023134-y665agnh 1068 6 human human JJ cord-023134-y665agnh 1068 7 cases case NNS cord-023134-y665agnh 1068 8 , , , cord-023134-y665agnh 1068 9 whereas whereas IN cord-023134-y665agnh 1068 10 the the DT cord-023134-y665agnh 1068 11 disease disease NN cord-023134-y665agnh 1068 12 is be VBZ cord-023134-y665agnh 1068 13 widespread widespread JJ cord-023134-y665agnh 1068 14 in in IN cord-023134-y665agnh 1068 15 dogs dog NNS cord-023134-y665agnh 1068 16 . . . cord-023134-y665agnh 1069 1 Shunts shunt NNS cord-023134-y665agnh 1069 2 are be VBP cord-023134-y665agnh 1069 3 more more RBR cord-023134-y665agnh 1069 4 frequently frequently RB cord-023134-y665agnh 1069 5 diagnosed diagnose VBN cord-023134-y665agnh 1069 6 in in IN cord-023134-y665agnh 1069 7 purebred purebred JJ cord-023134-y665agnh 1069 8 dogs dog NNS cord-023134-y665agnh 1069 9 than than IN cord-023134-y665agnh 1069 10 in in IN cord-023134-y665agnh 1069 11 crossbred crossbreed VBN cord-023134-y665agnh 1069 12 dogs dog NNS cord-023134-y665agnh 1069 13 . . . cord-023134-y665agnh 1070 1 The the DT cord-023134-y665agnh 1070 2 inheritance inheritance NN cord-023134-y665agnh 1070 3 is be VBZ cord-023134-y665agnh 1070 4 complex complex JJ cord-023134-y665agnh 1070 5 without without IN cord-023134-y665agnh 1070 6 sex sex NN cord-023134-y665agnh 1070 7 effect effect NN cord-023134-y665agnh 1070 8 . . . cord-023134-y665agnh 1071 1 A a DT cord-023134-y665agnh 1071 2 genome genome NN cord-023134-y665agnh 1071 3 wide wide JJ cord-023134-y665agnh 1071 4 association association NN cord-023134-y665agnh 1071 5 studied study VBD cord-023134-y665agnh 1071 6 with with IN cord-023134-y665agnh 1071 7 50 50 CD cord-023134-y665agnh 1071 8 K K NNP cord-023134-y665agnh 1071 9 SNPs SNPs NNPS cord-023134-y665agnh 1071 10 was be VBD cord-023134-y665agnh 1071 11 peformed peforme VBN cord-023134-y665agnh 1071 12 on on IN cord-023134-y665agnh 1071 13 48 48 CD cord-023134-y665agnh 1071 14 Cairn Cairn NNP cord-023134-y665agnh 1071 15 terrier terrier NN cord-023134-y665agnh 1071 16 cases case NNS cord-023134-y665agnh 1071 17 and and CC cord-023134-y665agnh 1071 18 48 48 CD cord-023134-y665agnh 1071 19 controls control NNS cord-023134-y665agnh 1071 20 of of IN cord-023134-y665agnh 1071 21 the the DT cord-023134-y665agnh 1071 22 same same JJ cord-023134-y665agnh 1071 23 breed breed NN cord-023134-y665agnh 1071 24 . . . cord-023134-y665agnh 1072 1 After after IN cord-023134-y665agnh 1072 2 quality quality NN cord-023134-y665agnh 1072 3 control control NN cord-023134-y665agnh 1072 4 42 42 CD cord-023134-y665agnh 1072 5 cases case NNS cord-023134-y665agnh 1072 6 and and CC cord-023134-y665agnh 1072 7 39 39 CD cord-023134-y665agnh 1072 8 controls control NNS cord-023134-y665agnh 1072 9 were be VBD cord-023134-y665agnh 1072 10 analyzed analyze VBN cord-023134-y665agnh 1072 11 in in IN cord-023134-y665agnh 1072 12 47702 47702 CD cord-023134-y665agnh 1072 13 SNPs snp NNS cord-023134-y665agnh 1072 14 . . . cord-023134-y665agnh 1073 1 Allelic Allelic NNP cord-023134-y665agnh 1073 2 association association NN cord-023134-y665agnh 1073 3 was be VBD cord-023134-y665agnh 1073 4 calculated calculate VBN cord-023134-y665agnh 1073 5 with with IN cord-023134-y665agnh 1073 6 PLINK PLINK NNP cord-023134-y665agnh 1073 7 and and CC cord-023134-y665agnh 1073 8 GRAMMAS GRAMMAS NNP cord-023134-y665agnh 1073 9 of of IN cord-023134-y665agnh 1073 10 the the DT cord-023134-y665agnh 1073 11 GenABEL GenABEL NNP cord-023134-y665agnh 1073 12 package package NN cord-023134-y665agnh 1073 13 was be VBD cord-023134-y665agnh 1073 14 used use VBN cord-023134-y665agnh 1073 15 to to TO cord-023134-y665agnh 1073 16 correct correct VB cord-023134-y665agnh 1073 17 for for IN cord-023134-y665agnh 1073 18 genetic genetic JJ cord-023134-y665agnh 1073 19 kinship kinship NN cord-023134-y665agnh 1073 20 . . . cord-023134-y665agnh 1074 1 Several several JJ cord-023134-y665agnh 1074 2 chromosome chromosome NN cord-023134-y665agnh 1074 3 regions region NNS cord-023134-y665agnh 1074 4 were be VBD cord-023134-y665agnh 1074 5 detected detect VBN cord-023134-y665agnh 1074 6 with with IN cord-023134-y665agnh 1074 7 close close RB cord-023134-y665agnh 1074 8 to to IN cord-023134-y665agnh 1074 9 significant significant JJ cord-023134-y665agnh 1074 10 association association NN cord-023134-y665agnh 1074 11 . . . cord-023134-y665agnh 1075 1 Overlap overlap VB cord-023134-y665agnh 1075 2 between between IN cord-023134-y665agnh 1075 3 the the DT cord-023134-y665agnh 1075 4 two two CD cord-023134-y665agnh 1075 5 analysis analysis NN cord-023134-y665agnh 1075 6 methods method NNS cord-023134-y665agnh 1075 7 was be VBD cord-023134-y665agnh 1075 8 found find VBN cord-023134-y665agnh 1075 9 on on IN cord-023134-y665agnh 1075 10 three three CD cord-023134-y665agnh 1075 11 genomic genomic JJ cord-023134-y665agnh 1075 12 regions region NNS cord-023134-y665agnh 1075 13 covering cover VBG cord-023134-y665agnh 1075 14 about about RB cord-023134-y665agnh 1075 15 8.4 8.4 CD cord-023134-y665agnh 1075 16 Mb Mb NNS cord-023134-y665agnh 1075 17 . . . cord-023134-y665agnh 1076 1 Finemapping Finemapping NNP cord-023134-y665agnh 1076 2 was be VBD cord-023134-y665agnh 1076 3 conducted conduct VBN cord-023134-y665agnh 1076 4 by by IN cord-023134-y665agnh 1076 5 analyzing analyze VBG cord-023134-y665agnh 1076 6 more more JJR cord-023134-y665agnh 1076 7 SNPs snp NNS cord-023134-y665agnh 1076 8 in in IN cord-023134-y665agnh 1076 9 a a DT cord-023134-y665agnh 1076 10 larger large JJR cord-023134-y665agnh 1076 11 group group NN cord-023134-y665agnh 1076 12 of of IN cord-023134-y665agnh 1076 13 Cairn Cairn NNP cord-023134-y665agnh 1076 14 terriers terrier NNS cord-023134-y665agnh 1076 15 and and CC cord-023134-y665agnh 1076 16 in in IN cord-023134-y665agnh 1076 17 cases case NNS cord-023134-y665agnh 1076 18 and and CC cord-023134-y665agnh 1076 19 controls control NNS cord-023134-y665agnh 1076 20 of of IN cord-023134-y665agnh 1076 21 8 8 CD cord-023134-y665agnh 1076 22 other other JJ cord-023134-y665agnh 1076 23 breeds breed NNS cord-023134-y665agnh 1076 24 . . . cord-023134-y665agnh 1077 1 The the DT cord-023134-y665agnh 1077 2 finemapping finemapping NN cord-023134-y665agnh 1077 3 resulted result VBD cord-023134-y665agnh 1077 4 in in IN cord-023134-y665agnh 1077 5 two two CD cord-023134-y665agnh 1077 6 genomic genomic JJ cord-023134-y665agnh 1077 7 regions region NNS cord-023134-y665agnh 1077 8 covering cover VBG cord-023134-y665agnh 1077 9 300 300 CD cord-023134-y665agnh 1077 10 and and CC cord-023134-y665agnh 1077 11 997 997 CD cord-023134-y665agnh 1077 12 kb kb NNS cord-023134-y665agnh 1077 13 that that WDT cord-023134-y665agnh 1077 14 were be VBD cord-023134-y665agnh 1077 15 associated associate VBN cord-023134-y665agnh 1077 16 with with IN cord-023134-y665agnh 1077 17 significant significant JJ cord-023134-y665agnh 1077 18 pvalues pvalue NNS cord-023134-y665agnh 1077 19 . . . cord-023134-y665agnh 1078 1 Comparison comparison NN cord-023134-y665agnh 1078 2 of of IN cord-023134-y665agnh 1078 3 haplotypes haplotype NNS cord-023134-y665agnh 1078 4 of of IN cord-023134-y665agnh 1078 5 cases case NNS cord-023134-y665agnh 1078 6 from from IN cord-023134-y665agnh 1078 7 different different JJ cord-023134-y665agnh 1078 8 breeds breed NNS cord-023134-y665agnh 1078 9 confirmed confirm VBD cord-023134-y665agnh 1078 10 the the DT cord-023134-y665agnh 1078 11 association association NN cord-023134-y665agnh 1078 12 signals signal NNS cord-023134-y665agnh 1078 13 . . . cord-023134-y665agnh 1079 1 The the DT cord-023134-y665agnh 1079 2 regions region NNS cord-023134-y665agnh 1079 3 of of IN cord-023134-y665agnh 1079 4 interest interest NN cord-023134-y665agnh 1079 5 are be VBP cord-023134-y665agnh 1079 6 analyzed analyze VBN cord-023134-y665agnh 1079 7 by by IN cord-023134-y665agnh 1079 8 NGS NGS NNP cord-023134-y665agnh 1079 9 of of IN cord-023134-y665agnh 1079 10 48 48 CD cord-023134-y665agnh 1079 11 cases case NNS cord-023134-y665agnh 1079 12 and and CC cord-023134-y665agnh 1079 13 48 48 CD cord-023134-y665agnh 1079 14 controls control NNS cord-023134-y665agnh 1079 15 . . . cord-023134-y665agnh 1080 1 Historically historically RB cord-023134-y665agnh 1080 2 , , , cord-023134-y665agnh 1080 3 doxycycline doxycycline NNP cord-023134-y665agnh 1080 4 has have VBZ cord-023134-y665agnh 1080 5 been be VBN cord-023134-y665agnh 1080 6 the the DT cord-023134-y665agnh 1080 7 first first JJ cord-023134-y665agnh 1080 8 line line NN cord-023134-y665agnh 1080 9 drug drug NN cord-023134-y665agnh 1080 10 for for IN cord-023134-y665agnh 1080 11 the the DT cord-023134-y665agnh 1080 12 treatment treatment NN cord-023134-y665agnh 1080 13 of of IN cord-023134-y665agnh 1080 14 canine canine JJ cord-023134-y665agnh 1080 15 monocytic monocytic JJ cord-023134-y665agnh 1080 16 ehrlichiosis ehrlichiosis NNP cord-023134-y665agnh 1080 17 ( ( -LRB- cord-023134-y665agnh 1080 18 CME CME NNP cord-023134-y665agnh 1080 19 ) ) -RRB- cord-023134-y665agnh 1080 20 . . . cord-023134-y665agnh 1081 1 Some some DT cord-023134-y665agnh 1081 2 studies study NNS cord-023134-y665agnh 1081 3 have have VBP cord-023134-y665agnh 1081 4 shown show VBN cord-023134-y665agnh 1081 5 that that IN cord-023134-y665agnh 1081 6 dogs dog NNS cord-023134-y665agnh 1081 7 may may MD cord-023134-y665agnh 1081 8 remain remain VB cord-023134-y665agnh 1081 9 carriers carrier NNS cord-023134-y665agnh 1081 10 despite despite IN cord-023134-y665agnh 1081 11 doxycyxline doxycyxline NN cord-023134-y665agnh 1081 12 treatment treatment NN cord-023134-y665agnh 1081 13 , , , cord-023134-y665agnh 1081 14 therefore therefore RB cord-023134-y665agnh 1081 15 investigation investigation NN cord-023134-y665agnh 1081 16 for for IN cord-023134-y665agnh 1081 17 other other JJ cord-023134-y665agnh 1081 18 anti anti JJ cord-023134-y665agnh 1081 19 - - JJ cord-023134-y665agnh 1081 20 ehrlichial ehrlichial JJ cord-023134-y665agnh 1081 21 agents agent NNS cord-023134-y665agnh 1081 22 may may MD cord-023134-y665agnh 1081 23 be be VB cord-023134-y665agnh 1081 24 warranted warrant VBN cord-023134-y665agnh 1081 25 . . . cord-023134-y665agnh 1082 1 Rifampin Rifampin NNP cord-023134-y665agnh 1082 2 was be VBD cord-023134-y665agnh 1082 3 suggested suggest VBN cord-023134-y665agnh 1082 4 as as IN cord-023134-y665agnh 1082 5 a a DT cord-023134-y665agnh 1082 6 promising promising JJ cord-023134-y665agnh 1082 7 alternative alternative NN cord-023134-y665agnh 1082 8 for for IN cord-023134-y665agnh 1082 9 the the DT cord-023134-y665agnh 1082 10 treatment treatment NN cord-023134-y665agnh 1082 11 of of IN cord-023134-y665agnh 1082 12 CME CME NNP cord-023134-y665agnh 1082 13 , , , cord-023134-y665agnh 1082 14 though though IN cord-023134-y665agnh 1082 15 its -PRON- PRP$ cord-023134-y665agnh 1082 16 efficacy efficacy NN cord-023134-y665agnh 1082 17 in in IN cord-023134-y665agnh 1082 18 clearing clear VBG cord-023134-y665agnh 1082 19 the the DT cord-023134-y665agnh 1082 20 infection infection NN cord-023134-y665agnh 1082 21 has have VBZ cord-023134-y665agnh 1082 22 not not RB cord-023134-y665agnh 1082 23 been be VBN cord-023134-y665agnh 1082 24 thoroughly thoroughly RB cord-023134-y665agnh 1082 25 evaluated evaluate VBN cord-023134-y665agnh 1082 26 . . . cord-023134-y665agnh 1083 1 The the DT cord-023134-y665agnh 1083 2 purpose purpose NN cord-023134-y665agnh 1083 3 of of IN cord-023134-y665agnh 1083 4 this this DT cord-023134-y665agnh 1083 5 study study NN cord-023134-y665agnh 1083 6 was be VBD cord-023134-y665agnh 1083 7 to to TO cord-023134-y665agnh 1083 8 assess assess VB cord-023134-y665agnh 1083 9 the the DT cord-023134-y665agnh 1083 10 efficacy efficacy NN cord-023134-y665agnh 1083 11 of of IN cord-023134-y665agnh 1083 12 rifampin rifampin NN cord-023134-y665agnh 1083 13 in in IN cord-023134-y665agnh 1083 14 achieving achieve VBG cord-023134-y665agnh 1083 15 clinicopathological clinicopathological NNP cord-023134-y665agnh 1083 16 recovery recovery NN cord-023134-y665agnh 1083 17 and and CC cord-023134-y665agnh 1083 18 clearing clear VBG cord-023134-y665agnh 1083 19 the the DT cord-023134-y665agnh 1083 20 ehrlichial ehrlichial JJ cord-023134-y665agnh 1083 21 infection infection NN cord-023134-y665agnh 1083 22 from from IN cord-023134-y665agnh 1083 23 the the DT cord-023134-y665agnh 1083 24 blood blood NN cord-023134-y665agnh 1083 25 and and CC cord-023134-y665agnh 1083 26 other other JJ cord-023134-y665agnh 1083 27 tissues tissue NNS cord-023134-y665agnh 1083 28 in in IN cord-023134-y665agnh 1083 29 dogs dog NNS cord-023134-y665agnh 1083 30 with with IN cord-023134-y665agnh 1083 31 experimentally experimentally RB cord-023134-y665agnh 1083 32 - - HYPH cord-023134-y665agnh 1083 33 induced induce VBN cord-023134-y665agnh 1083 34 acute acute NN cord-023134-y665agnh 1083 35 CME CME NNP cord-023134-y665agnh 1083 36 . . . cord-023134-y665agnh 1084 1 Of of IN cord-023134-y665agnh 1084 2 the the DT cord-023134-y665agnh 1084 3 16 16 CD cord-023134-y665agnh 1084 4 purpose purpose NN cord-023134-y665agnh 1084 5 - - HYPH cord-023134-y665agnh 1084 6 bred breed VBN cord-023134-y665agnh 1084 7 Beagle Beagle NNP cord-023134-y665agnh 1084 8 dogs dog NNS cord-023134-y665agnh 1084 9 that that WDT cord-023134-y665agnh 1084 10 were be VBD cord-023134-y665agnh 1084 11 included include VBN cord-023134-y665agnh 1084 12 in in IN cord-023134-y665agnh 1084 13 the the DT cord-023134-y665agnh 1084 14 study study NN cord-023134-y665agnh 1084 15 , , , cord-023134-y665agnh 1084 16 5 5 CD cord-023134-y665agnh 1084 17 dogs dog NNS cord-023134-y665agnh 1084 18 with with IN cord-023134-y665agnh 1084 19 acute acute JJ cord-023134-y665agnh 1084 20 experimental experimental JJ cord-023134-y665agnh 1084 21 CME CME NNP cord-023134-y665agnh 1084 22 were be VBD cord-023134-y665agnh 1084 23 treated treat VBN cord-023134-y665agnh 1084 24 with with IN cord-023134-y665agnh 1084 25 rifampin rifampin NN cord-023134-y665agnh 1084 26 ( ( -LRB- cord-023134-y665agnh 1084 27 10 10 CD cord-023134-y665agnh 1084 28 mg mg NNP cord-023134-y665agnh 1084 29 / / SYM cord-023134-y665agnh 1084 30 Kg Kg NNP cord-023134-y665agnh 1084 31 , , , cord-023134-y665agnh 1084 32 SID SID NNP cord-023134-y665agnh 1084 33 , , , cord-023134-y665agnh 1084 34 PO PO NNP cord-023134-y665agnh 1084 35 , , , cord-023134-y665agnh 1084 36 for for IN cord-023134-y665agnh 1084 37 3 3 CD cord-023134-y665agnh 1084 38 weeks week NNS cord-023134-y665agnh 1084 39 ) ) -RRB- cord-023134-y665agnh 1084 40 , , , cord-023134-y665agnh 1084 41 9 9 CD cord-023134-y665agnh 1084 42 infected infected JJ cord-023134-y665agnh 1084 43 dogs dog NNS cord-023134-y665agnh 1084 44 received receive VBD cord-023134-y665agnh 1084 45 no no DT cord-023134-y665agnh 1084 46 rifampin rifampin NN cord-023134-y665agnh 1084 47 ( ( -LRB- cord-023134-y665agnh 1084 48 infected infect VBN cord-023134-y665agnh 1084 49 controls control NNS cord-023134-y665agnh 1084 50 ) ) -RRB- cord-023134-y665agnh 1084 51 and and CC cord-023134-y665agnh 1084 52 two two CD cord-023134-y665agnh 1084 53 dogs dog NNS cord-023134-y665agnh 1084 54 served serve VBD cord-023134-y665agnh 1084 55 as as IN cord-023134-y665agnh 1084 56 uninfected uninfected JJ cord-023134-y665agnh 1084 57 controls control NNS cord-023134-y665agnh 1084 58 . . . cord-023134-y665agnh 1085 1 Fourteen fourteen CD cord-023134-y665agnh 1085 2 days day NNS cord-023134-y665agnh 1085 3 after after IN cord-023134-y665agnh 1085 4 the the DT cord-023134-y665agnh 1085 5 completion completion NN cord-023134-y665agnh 1085 6 of of IN cord-023134-y665agnh 1085 7 rifampin rifampin NNP cord-023134-y665agnh 1085 8 treatment treatment NN cord-023134-y665agnh 1085 9 , , , cord-023134-y665agnh 1085 10 dexamethazone dexamethazone NNP cord-023134-y665agnh 1085 11 ( ( -LRB- cord-023134-y665agnh 1085 12 0.5 0.5 CD cord-023134-y665agnh 1085 13 mg mg NNP cord-023134-y665agnh 1085 14 / / SYM cord-023134-y665agnh 1085 15 Kg Kg NNP cord-023134-y665agnh 1085 16 , , , cord-023134-y665agnh 1085 17 IV IV NNP cord-023134-y665agnh 1085 18 , , , cord-023134-y665agnh 1085 19 once once RB cord-023134-y665agnh 1085 20 ) ) -RRB- cord-023134-y665agnh 1085 21 was be VBD cord-023134-y665agnh 1085 22 given give VBN cord-023134-y665agnh 1085 23 to to IN cord-023134-y665agnh 1085 24 the the DT cord-023134-y665agnh 1085 25 5 5 CD cord-023134-y665agnh 1085 26 rifampin rifampin NN cord-023134-y665agnh 1085 27 - - HYPH cord-023134-y665agnh 1085 28 treated treat VBN cord-023134-y665agnh 1085 29 dogs dog NNS cord-023134-y665agnh 1085 30 . . . cord-023134-y665agnh 1086 1 Clinical clinical JJ cord-023134-y665agnh 1086 2 score score NN cord-023134-y665agnh 1086 3 , , , cord-023134-y665agnh 1086 4 platelet platelet NN cord-023134-y665agnh 1086 5 counts count NNS cord-023134-y665agnh 1086 6 , , , cord-023134-y665agnh 1086 7 anti anti JJ cord-023134-y665agnh 1086 8 - - JJ cord-023134-y665agnh 1086 9 E. e. JJ cord-023134-y665agnh 1086 10 canis canis NNP cord-023134-y665agnh 1086 11 immunofluorsecent immunofluorsecent JJ cord-023134-y665agnh 1086 12 antibody antibody NN cord-023134-y665agnh 1086 13 titers titers NNP cord-023134-y665agnh 1086 14 ( ( -LRB- cord-023134-y665agnh 1086 15 IFA IFA NNP cord-023134-y665agnh 1086 16 ) ) -RRB- cord-023134-y665agnh 1086 17 and and CC cord-023134-y665agnh 1086 18 polymerase polymerase NN cord-023134-y665agnh 1086 19 chain chain NN cord-023134-y665agnh 1086 20 reaction reaction NN cord-023134-y665agnh 1086 21 ( ( -LRB- cord-023134-y665agnh 1086 22 PCR PCR NNP cord-023134-y665agnh 1086 23 ) ) -RRB- cord-023134-y665agnh 1086 24 detection detection NN cord-023134-y665agnh 1086 25 of of IN cord-023134-y665agnh 1086 26 E. E. NNP cord-023134-y665agnh 1086 27 canis canis NN cord-023134-y665agnh 1086 28 - - HYPH cord-023134-y665agnh 1086 29 specific specific JJ cord-023134-y665agnh 1086 30 deoxyribonucleic deoxyribonucleic NN cord-023134-y665agnh 1086 31 acid acid NN cord-023134-y665agnh 1086 32 in in IN cord-023134-y665agnh 1086 33 the the DT cord-023134-y665agnh 1086 34 blood blood NN cord-023134-y665agnh 1086 35 , , , cord-023134-y665agnh 1086 36 bone bone NN cord-023134-y665agnh 1086 37 marrow marrow NN cord-023134-y665agnh 1086 38 and and CC cord-023134-y665agnh 1086 39 spleen spleen NN cord-023134-y665agnh 1086 40 aspirates aspirate NNS cord-023134-y665agnh 1086 41 were be VBD cord-023134-y665agnh 1086 42 evaluated evaluate VBN cord-023134-y665agnh 1086 43 between between IN cord-023134-y665agnh 1086 44 the the DT cord-023134-y665agnh 1086 45 treated treat VBN cord-023134-y665agnh 1086 46 and and CC cord-023134-y665agnh 1086 47 untreated untreated JJ cord-023134-y665agnh 1086 48 infected infected JJ cord-023134-y665agnh 1086 49 dogs dog NNS cord-023134-y665agnh 1086 50 on on IN cord-023134-y665agnh 1086 51 day day NN cord-023134-y665agnh 1086 52 21 21 CD cord-023134-y665agnh 1086 53 post post NN cord-023134-y665agnh 1086 54 - - NN cord-023134-y665agnh 1086 55 inoculation inoculation JJ cord-023134-y665agnh 1086 56 ( ( -LRB- cord-023134-y665agnh 1086 57 PI pi NN cord-023134-y665agnh 1086 58 ) ) -RRB- cord-023134-y665agnh 1087 1 ( ( -LRB- cord-023134-y665agnh 1087 2 start start NN cord-023134-y665agnh 1087 3 of of IN cord-023134-y665agnh 1087 4 rifampin rifampin NN cord-023134-y665agnh 1087 5 ) ) -RRB- cord-023134-y665agnh 1087 6 , , . cord-023134-y665agnh 1088 1 on on IN cord-023134-y665agnh 1088 2 day day NN cord-023134-y665agnh 1088 3 42 42 CD cord-023134-y665agnh 1088 4 PI pi NN cord-023134-y665agnh 1088 5 ( ( -LRB- cord-023134-y665agnh 1088 6 end end NN cord-023134-y665agnh 1088 7 of of IN cord-023134-y665agnh 1088 8 rifampin rifampin NN cord-023134-y665agnh 1088 9 ) ) -RRB- cord-023134-y665agnh 1088 10 and and CC cord-023134-y665agnh 1088 11 day day NN cord-023134-y665agnh 1088 12 98 98 CD cord-023134-y665agnh 1088 13 PI pi NN cord-023134-y665agnh 1088 14 ( ( -LRB- cord-023134-y665agnh 1088 15 end end NN cord-023134-y665agnh 1088 16 of of IN cord-023134-y665agnh 1088 17 post post JJ cord-023134-y665agnh 1088 18 - - JJ cord-023134-y665agnh 1088 19 treatment treatment JJ cord-023134-y665agnh 1088 20 monitoring monitoring NN cord-023134-y665agnh 1088 21 ) ) -RRB- cord-023134-y665agnh 1088 22 . . . cord-023134-y665agnh 1089 1 By by IN cord-023134-y665agnh 1089 2 day day NN cord-023134-y665agnh 1089 3 21 21 CD cord-023134-y665agnh 1089 4 PI pi NN cord-023134-y665agnh 1089 5 , , , cord-023134-y665agnh 1089 6 all all DT cord-023134-y665agnh 1089 7 infected infect VBN cord-023134-y665agnh 1089 8 dogs dog NNS cord-023134-y665agnh 1089 9 became become VBD cord-023134-y665agnh 1089 10 clinically clinically RB cord-023134-y665agnh 1089 11 ill ill JJ cord-023134-y665agnh 1089 12 and and CC cord-023134-y665agnh 1089 13 thrombocytopenic thrombocytopenic JJ cord-023134-y665agnh 1089 14 , , , cord-023134-y665agnh 1089 15 seroconverted seroconverte VBD cord-023134-y665agnh 1089 16 and and CC cord-023134-y665agnh 1089 17 became become VBD cord-023134-y665agnh 1089 18 PCR PCR NNP cord-023134-y665agnh 1089 19 - - HYPH cord-023134-y665agnh 1089 20 positive positive JJ cord-023134-y665agnh 1089 21 in in IN cord-023134-y665agnh 1089 22 at at RB cord-023134-y665agnh 1089 23 least least RBS cord-023134-y665agnh 1089 24 one one CD cord-023134-y665agnh 1089 25 tissue tissue NN cord-023134-y665agnh 1089 26 . . . cord-023134-y665agnh 1090 1 The the DT cord-023134-y665agnh 1090 2 median median JJ cord-023134-y665agnh 1090 3 clinical clinical JJ cord-023134-y665agnh 1090 4 score score NN cord-023134-y665agnh 1090 5 and and CC cord-023134-y665agnh 1090 6 IFA IFA NNP cord-023134-y665agnh 1090 7 titers titer NNS cord-023134-y665agnh 1090 8 did do VBD cord-023134-y665agnh 1090 9 not not RB cord-023134-y665agnh 1090 10 differ differ VB cord-023134-y665agnh 1090 11 between between IN cord-023134-y665agnh 1090 12 the the DT cord-023134-y665agnh 1090 13 treated treat VBN cord-023134-y665agnh 1090 14 and and CC cord-023134-y665agnh 1090 15 untreated untreated JJ cord-023134-y665agnh 1090 16 dogs dog NNS cord-023134-y665agnh 1090 17 at at IN cord-023134-y665agnh 1090 18 any any DT cord-023134-y665agnh 1090 19 of of IN cord-023134-y665agnh 1090 20 the the DT cord-023134-y665agnh 1090 21 three three CD cord-023134-y665agnh 1090 22 time time NN cord-023134-y665agnh 1090 23 points point NNS cord-023134-y665agnh 1090 24 . . . cord-023134-y665agnh 1091 1 Μedian μedian JJ cord-023134-y665agnh 1091 2 platelet platelet NN cord-023134-y665agnh 1091 3 counts count NNS cord-023134-y665agnh 1091 4 were be VBD cord-023134-y665agnh 1091 5 significantly significantly RB cord-023134-y665agnh 1091 6 higher high JJR cord-023134-y665agnh 1091 7 in in IN cord-023134-y665agnh 1091 8 the the DT cord-023134-y665agnh 1091 9 treated treat VBN cord-023134-y665agnh 1091 10 compared compare VBN cord-023134-y665agnh 1091 11 to to IN cord-023134-y665agnh 1091 12 the the DT cord-023134-y665agnh 1091 13 untreated untreated JJ cord-023134-y665agnh 1091 14 infected infected JJ cord-023134-y665agnh 1091 15 dogs dog NNS cord-023134-y665agnh 1091 16 on on IN cord-023134-y665agnh 1091 17 day day NN cord-023134-y665agnh 1091 18 42 42 CD cord-023134-y665agnh 1091 19 PI pi NN cord-023134-y665agnh 1091 20 ( ( -LRB- cord-023134-y665agnh 1091 21 251,000 251,000 CD cord-023134-y665agnh 1091 22 / / SYM cord-023134-y665agnh 1091 23 ll ll VB cord-023134-y665agnh 1091 24 versus versus IN cord-023134-y665agnh 1091 25 168,000 168,000 CD cord-023134-y665agnh 1091 26 , , , cord-023134-y665agnh 1091 27 P=0.0233 P=0.0233 NNP cord-023134-y665agnh 1091 28 ) ) -RRB- cord-023134-y665agnh 1091 29 and and CC cord-023134-y665agnh 1091 30 day day NN cord-023134-y665agnh 1091 31 98 98 CD cord-023134-y665agnh 1091 32 PI pi NN cord-023134-y665agnh 1091 33 ( ( -LRB- cord-023134-y665agnh 1091 34 254,000 254,000 CD cord-023134-y665agnh 1091 35 / / SYM cord-023134-y665agnh 1091 36 ll ll VB cord-023134-y665agnh 1091 37 versus versus IN cord-023134-y665agnh 1091 38 205,000 205,000 CD cord-023134-y665agnh 1091 39 / / SYM cord-023134-y665agnh 1091 40 ll ll VBP cord-023134-y665agnh 1091 41 , , , cord-023134-y665agnh 1091 42 P=0.0195 P=0.0195 NNP cord-023134-y665agnh 1091 43 ) ) -RRB- cord-023134-y665agnh 1091 44 ( ( -LRB- cord-023134-y665agnh 1091 45 two two CD cord-023134-y665agnh 1091 46 - - HYPH cord-023134-y665agnh 1091 47 sample sample NN cord-023134-y665agnh 1092 1 Wilcoxon Wilcoxon NNP cord-023134-y665agnh 1092 2 rank rank NN cord-023134-y665agnh 1092 3 - - HYPH cord-023134-y665agnh 1092 4 sum sum NN cord-023134-y665agnh 1092 5 [ [ -LRB- cord-023134-y665agnh 1092 6 Mann Mann NNP cord-023134-y665agnh 1092 7 - - HYPH cord-023134-y665agnh 1092 8 Whitney Whitney NNP cord-023134-y665agnh 1092 9 ] ] -RRB- cord-023134-y665agnh 1092 10 test test NN cord-023134-y665agnh 1092 11 ) ) -RRB- cord-023134-y665agnh 1092 12 . . . cord-023134-y665agnh 1093 1 On on IN cord-023134-y665agnh 1093 2 day day NN cord-023134-y665agnh 1093 3 42 42 CD cord-023134-y665agnh 1093 4 PI pi NN cord-023134-y665agnh 1093 5 , , , cord-023134-y665agnh 1093 6 2 2 CD cord-023134-y665agnh 1093 7 treated treat VBN cord-023134-y665agnh 1093 8 and and CC cord-023134-y665agnh 1094 1 2 2 CD cord-023134-y665agnh 1094 2 untreated untreated JJ cord-023134-y665agnh 1094 3 infected infect VBN cord-023134-y665agnh 1094 4 dogs dog NNS cord-023134-y665agnh 1094 5 were be VBD cord-023134-y665agnh 1094 6 PCR pcr NN cord-023134-y665agnh 1094 7 - - HYPH cord-023134-y665agnh 1094 8 positive positive JJ cord-023134-y665agnh 1094 9 , , , cord-023134-y665agnh 1094 10 while while IN cord-023134-y665agnh 1094 11 on on IN cord-023134-y665agnh 1094 12 day day NN cord-023134-y665agnh 1094 13 98 98 CD cord-023134-y665agnh 1094 14 PI pi NN cord-023134-y665agnh 1094 15 , , , cord-023134-y665agnh 1094 16 3 3 CD cord-023134-y665agnh 1094 17 treated treat VBD cord-023134-y665agnh 1094 18 and and CC cord-023134-y665agnh 1094 19 6 6 CD cord-023134-y665agnh 1094 20 untreated untreated JJ cord-023134-y665agnh 1094 21 infected infect VBN cord-023134-y665agnh 1094 22 dogs dog NNS cord-023134-y665agnh 1094 23 remained remain VBD cord-023134-y665agnh 1094 24 PCR PCR NNP cord-023134-y665agnh 1094 25 positive positive JJ cord-023134-y665agnh 1094 26 in in IN cord-023134-y665agnh 1094 27 at at RB cord-023134-y665agnh 1094 28 least least RBS cord-023134-y665agnh 1094 29 one one CD cord-023134-y665agnh 1094 30 of of IN cord-023134-y665agnh 1094 31 the the DT cord-023134-y665agnh 1094 32 tissues tissue NNS cord-023134-y665agnh 1094 33 tested test VBN cord-023134-y665agnh 1094 34 . . . cord-023134-y665agnh 1095 1 As as IN cord-023134-y665agnh 1095 2 administered administer VBN cord-023134-y665agnh 1095 3 in in IN cord-023134-y665agnh 1095 4 this this DT cord-023134-y665agnh 1095 5 study study NN cord-023134-y665agnh 1095 6 , , , cord-023134-y665agnh 1095 7 rifampin rifampin NNP cord-023134-y665agnh 1095 8 hastened hasten VBD cord-023134-y665agnh 1095 9 hematological hematological JJ cord-023134-y665agnh 1095 10 recovery recovery NN cord-023134-y665agnh 1095 11 of of IN cord-023134-y665agnh 1095 12 the the DT cord-023134-y665agnh 1095 13 infected infect VBN cord-023134-y665agnh 1095 14 dogs dog NNS cord-023134-y665agnh 1095 15 , , , cord-023134-y665agnh 1095 16 but but CC cord-023134-y665agnh 1095 17 was be VBD cord-023134-y665agnh 1095 18 inconsistent inconsistent JJ cord-023134-y665agnh 1095 19 in in IN cord-023134-y665agnh 1095 20 clearing clear VBG cord-023134-y665agnh 1095 21 the the DT cord-023134-y665agnh 1095 22 experimentally experimentally RB cord-023134-y665agnh 1095 23 - - HYPH cord-023134-y665agnh 1095 24 induced induce VBN cord-023134-y665agnh 1095 25 acute acute JJ cord-023134-y665agnh 1095 26 E. E. NNP cord-023134-y665agnh 1095 27 canis canis FW cord-023134-y665agnh 1095 28 infection infection NN cord-023134-y665agnh 1095 29 . . . cord-023134-y665agnh 1096 1 Acute acute JJ cord-023134-y665agnh 1096 2 phase phase NN cord-023134-y665agnh 1096 3 proteins protein NNS cord-023134-y665agnh 1096 4 ( ( -LRB- cord-023134-y665agnh 1096 5 APP app NN cord-023134-y665agnh 1096 6 ) ) -RRB- cord-023134-y665agnh 1096 7 are be VBP cord-023134-y665agnh 1096 8 considered consider VBN cord-023134-y665agnh 1096 9 one one CD cord-023134-y665agnh 1096 10 of of IN cord-023134-y665agnh 1096 11 the the DT cord-023134-y665agnh 1096 12 hallmarks hallmark NNS cord-023134-y665agnh 1096 13 of of IN cord-023134-y665agnh 1096 14 the the DT cord-023134-y665agnh 1096 15 inflammatory inflammatory JJ cord-023134-y665agnh 1096 16 response response NN cord-023134-y665agnh 1096 17 . . . cord-023134-y665agnh 1097 1 Among among IN cord-023134-y665agnh 1097 2 their -PRON- PRP$ cord-023134-y665agnh 1097 3 major major JJ cord-023134-y665agnh 1097 4 functions function NNS cord-023134-y665agnh 1097 5 , , , cord-023134-y665agnh 1097 6 APPs app NNS cord-023134-y665agnh 1097 7 seem seem VBP cord-023134-y665agnh 1097 8 to to TO cord-023134-y665agnh 1097 9 modulate modulate VB cord-023134-y665agnh 1097 10 innate innate JJ cord-023134-y665agnh 1097 11 immune immune JJ cord-023134-y665agnh 1097 12 system system NN cord-023134-y665agnh 1097 13 efficiency efficiency NN cord-023134-y665agnh 1097 14 . . . cord-023134-y665agnh 1098 1 In in IN cord-023134-y665agnh 1098 2 cats cat NNS cord-023134-y665agnh 1098 3 , , , cord-023134-y665agnh 1098 4 serum serum NN cord-023134-y665agnh 1098 5 amyloid amyloid NN cord-023134-y665agnh 1098 6 A A NNP cord-023134-y665agnh 1098 7 ( ( -LRB- cord-023134-y665agnh 1098 8 SAA SAA NNP cord-023134-y665agnh 1098 9 ) ) -RRB- cord-023134-y665agnh 1098 10 and and CC cord-023134-y665agnh 1098 11 a1glycoprotein a1glycoprotein NNP cord-023134-y665agnh 1098 12 ( ( -LRB- cord-023134-y665agnh 1098 13 AGP AGP NNP cord-023134-y665agnh 1098 14 ) ) -RRB- cord-023134-y665agnh 1098 15 are be VBP cord-023134-y665agnh 1098 16 two two CD cord-023134-y665agnh 1098 17 major major JJ cord-023134-y665agnh 1098 18 positive positive JJ cord-023134-y665agnh 1098 19 APPs app NNS cord-023134-y665agnh 1098 20 that that WDT cord-023134-y665agnh 1098 21 are be VBP cord-023134-y665agnh 1098 22 increased increase VBN cord-023134-y665agnh 1098 23 during during IN cord-023134-y665agnh 1098 24 inflammation inflammation NN cord-023134-y665agnh 1098 25 . . . cord-023134-y665agnh 1099 1 This this DT cord-023134-y665agnh 1099 2 rise rise NN cord-023134-y665agnh 1099 3 is be VBZ cord-023134-y665agnh 1099 4 presumed presume VBN cord-023134-y665agnh 1099 5 to to TO cord-023134-y665agnh 1099 6 be be VB cord-023134-y665agnh 1099 7 secondary secondary JJ cord-023134-y665agnh 1099 8 to to IN cord-023134-y665agnh 1099 9 various various JJ cord-023134-y665agnh 1099 10 cytokines cytokine NNS cord-023134-y665agnh 1099 11 that that WDT cord-023134-y665agnh 1099 12 are be VBP cord-023134-y665agnh 1099 13 involved involve VBN cord-023134-y665agnh 1099 14 in in IN cord-023134-y665agnh 1099 15 the the DT cord-023134-y665agnh 1099 16 innate innate JJ cord-023134-y665agnh 1099 17 inflammatory inflammatory JJ cord-023134-y665agnh 1099 18 response response NN cord-023134-y665agnh 1099 19 . . . cord-023134-y665agnh 1100 1 Recombinant recombinant JJ cord-023134-y665agnh 1100 2 Feline Feline NNP cord-023134-y665agnh 1100 3 Interferon Interferon NNP cord-023134-y665agnh 1101 1 -x -x : cord-023134-y665agnh 1101 2 ( ( -LRB- cord-023134-y665agnh 1101 3 rFeIFN rfeifn NN cord-023134-y665agnh 1101 4 - - HYPH cord-023134-y665agnh 1101 5 x x LS cord-023134-y665agnh 1101 6 ) ) -RRB- cord-023134-y665agnh 1101 7 is be VBZ cord-023134-y665agnh 1101 8 an an DT cord-023134-y665agnh 1101 9 immune immune JJ cord-023134-y665agnh 1101 10 - - HYPH cord-023134-y665agnh 1101 11 modulator modulator NN cord-023134-y665agnh 1101 12 drug drug NN cord-023134-y665agnh 1101 13 that that WDT cord-023134-y665agnh 1101 14 is be VBZ cord-023134-y665agnh 1101 15 commonly commonly RB cord-023134-y665agnh 1101 16 used use VBN cord-023134-y665agnh 1101 17 in in IN cord-023134-y665agnh 1101 18 cats cat NNS cord-023134-y665agnh 1101 19 naturally naturally RB cord-023134-y665agnh 1101 20 infected infect VBN cord-023134-y665agnh 1101 21 with with IN cord-023134-y665agnh 1101 22 retroviruses retrovirus NNS cord-023134-y665agnh 1101 23 , , , cord-023134-y665agnh 1101 24 namely namely RB cord-023134-y665agnh 1101 25 feline feline JJ cord-023134-y665agnh 1101 26 immunodeficiency immunodeficiency NN cord-023134-y665agnh 1101 27 virus virus NN cord-023134-y665agnh 1101 28 ( ( -LRB- cord-023134-y665agnh 1101 29 FIV FIV NNP cord-023134-y665agnh 1101 30 ) ) -RRB- cord-023134-y665agnh 1101 31 and and CC cord-023134-y665agnh 1101 32 feline feline JJ cord-023134-y665agnh 1101 33 leukemia leukemia NN cord-023134-y665agnh 1101 34 virus virus NN cord-023134-y665agnh 1101 35 ( ( -LRB- cord-023134-y665agnh 1101 36 FeLV FeLV NNP cord-023134-y665agnh 1101 37 ) ) -RRB- cord-023134-y665agnh 1101 38 . . . cord-023134-y665agnh 1102 1 Several several JJ cord-023134-y665agnh 1102 2 studies study NNS cord-023134-y665agnh 1102 3 have have VBP cord-023134-y665agnh 1102 4 been be VBN cord-023134-y665agnh 1102 5 performed perform VBN cord-023134-y665agnh 1102 6 to to TO cord-023134-y665agnh 1102 7 clarify clarify VB cord-023134-y665agnh 1102 8 the the DT cord-023134-y665agnh 1102 9 clinical clinical JJ cord-023134-y665agnh 1102 10 benefits benefit NNS cord-023134-y665agnh 1102 11 of of IN cord-023134-y665agnh 1102 12 rFeIFN rfeifn NN cord-023134-y665agnh 1102 13 - - HYPH cord-023134-y665agnh 1102 14 x x NN cord-023134-y665agnh 1102 15 therapy therapy NN cord-023134-y665agnh 1102 16 in in IN cord-023134-y665agnh 1102 17 naturally naturally RB cord-023134-y665agnh 1102 18 infected infect VBN cord-023134-y665agnh 1102 19 FIV fiv NN cord-023134-y665agnh 1102 20 and/or and/or CC cord-023134-y665agnh 1102 21 FeLV felv NN cord-023134-y665agnh 1102 22 cats cat NNS cord-023134-y665agnh 1102 23 . . . cord-023134-y665agnh 1103 1 Our -PRON- PRP$ cord-023134-y665agnh 1103 2 group group NN cord-023134-y665agnh 1103 3 has have VBZ cord-023134-y665agnh 1103 4 previously previously RB cord-023134-y665agnh 1103 5 described describe VBN cord-023134-y665agnh 1103 6 that that IN cord-023134-y665agnh 1103 7 C C NNP cord-023134-y665agnh 1103 8 - - HYPH cord-023134-y665agnh 1103 9 reactive reactive JJ cord-023134-y665agnh 1103 10 Protein Protein NNP cord-023134-y665agnh 1103 11 ( ( -LRB- cord-023134-y665agnh 1103 12 CRP CRP NNP cord-023134-y665agnh 1103 13 ) ) -RRB- cord-023134-y665agnh 1103 14 increased increase VBD cord-023134-y665agnh 1103 15 in in IN cord-023134-y665agnh 1103 16 naturally naturally RB cord-023134-y665agnh 1103 17 retroviralinfected retroviralinfecte VBN cord-023134-y665agnh 1103 18 cats cat NNS cord-023134-y665agnh 1103 19 under under IN cord-023134-y665agnh 1103 20 rFeIFN rFeIFN NNP cord-023134-y665agnh 1103 21 - - HYPH cord-023134-y665agnh 1103 22 x x NN cord-023134-y665agnh 1103 23 therapy therapy NN cord-023134-y665agnh 1103 24 . . . cord-023134-y665agnh 1104 1 However however RB cord-023134-y665agnh 1104 2 , , , cord-023134-y665agnh 1104 3 the the DT cord-023134-y665agnh 1104 4 role role NN cord-023134-y665agnh 1104 5 of of IN cord-023134-y665agnh 1104 6 APPs app NNS cord-023134-y665agnh 1104 7 such such JJ cord-023134-y665agnh 1104 8 as as IN cord-023134-y665agnh 1104 9 SAA SAA NNP cord-023134-y665agnh 1104 10 , , , cord-023134-y665agnh 1104 11 AGP AGP NNP cord-023134-y665agnh 1104 12 and and CC cord-023134-y665agnh 1104 13 CRP CRP NNP cord-023134-y665agnh 1104 14 in in IN cord-023134-y665agnh 1104 15 the the DT cord-023134-y665agnh 1104 16 innate innate JJ cord-023134-y665agnh 1104 17 immuneresponse immuneresponse NN cord-023134-y665agnh 1104 18 , , , cord-023134-y665agnh 1104 19 remains remain VBZ cord-023134-y665agnh 1104 20 unknown unknown JJ cord-023134-y665agnh 1104 21 . . . cord-023134-y665agnh 1105 1 The the DT cord-023134-y665agnh 1105 2 aim aim NN cord-023134-y665agnh 1105 3 of of IN cord-023134-y665agnh 1105 4 this this DT cord-023134-y665agnh 1105 5 study study NN cord-023134-y665agnh 1105 6 was be VBD cord-023134-y665agnh 1105 7 to to TO cord-023134-y665agnh 1105 8 evaluate evaluate VB cord-023134-y665agnh 1105 9 SAA SAA NNP cord-023134-y665agnh 1105 10 , , , cord-023134-y665agnh 1105 11 AGP AGP NNP cord-023134-y665agnh 1105 12 and and CC cord-023134-y665agnh 1105 13 CRP CRP NNP cord-023134-y665agnh 1105 14 serum serum NN cord-023134-y665agnh 1105 15 levels level NNS cord-023134-y665agnh 1105 16 in in IN cord-023134-y665agnh 1105 17 naturally naturally RB cord-023134-y665agnh 1105 18 retroviralinfected retroviralinfecte VBN cord-023134-y665agnh 1105 19 cats cat NNS cord-023134-y665agnh 1105 20 under under IN cord-023134-y665agnh 1105 21 rFeIFN rFeIFN NNP cord-023134-y665agnh 1105 22 - - HYPH cord-023134-y665agnh 1105 23 x x NN cord-023134-y665agnh 1105 24 therapy therapy NN cord-023134-y665agnh 1105 25 . . . cord-023134-y665agnh 1106 1 Sixteen sixteen CD cord-023134-y665agnh 1107 1 naturally naturally RB cord-023134-y665agnh 1107 2 retroviral retroviral VB cord-023134-y665agnh 1107 3 infected infected JJ cord-023134-y665agnh 1107 4 cats cat NNS cord-023134-y665agnh 1107 5 ( ( -LRB- cord-023134-y665agnh 1107 6 7 7 CD cord-023134-y665agnh 1107 7 FIV FIV NNP cord-023134-y665agnh 1107 8 , , , cord-023134-y665agnh 1107 9 6 6 CD cord-023134-y665agnh 1107 10 FeLV felv NN cord-023134-y665agnh 1107 11 and and CC cord-023134-y665agnh 1107 12 3 3 CD cord-023134-y665agnh 1107 13 co co NN cord-023134-y665agnh 1107 14 - - JJ cord-023134-y665agnh 1107 15 infected infected JJ cord-023134-y665agnh 1108 1 FIV FIV NNP cord-023134-y665agnh 1108 2 / / SYM cord-023134-y665agnh 1108 3 FeLV FeLV NNP cord-023134-y665agnh 1108 4 stray stray JJ cord-023134-y665agnh 1108 5 cats cat NNS cord-023134-y665agnh 1108 6 ) ) -RRB- cord-023134-y665agnh 1108 7 housed house VBN cord-023134-y665agnh 1108 8 in in IN cord-023134-y665agnh 1108 9 a a DT cord-023134-y665agnh 1108 10 LisbonAnimal LisbonAnimal NNP cord-023134-y665agnh 1108 11 Rescue Rescue NNP cord-023134-y665agnh 1108 12 Shelter Shelter NNP cord-023134-y665agnh 1108 13 were be VBD cord-023134-y665agnh 1108 14 submitted submit VBN cord-023134-y665agnh 1108 15 to to IN cord-023134-y665agnh 1108 16 rFeIFN rfeifn NN cord-023134-y665agnh 1108 17 - - HYPH cord-023134-y665agnh 1108 18 x x NN cord-023134-y665agnh 1108 19 therapy therapy NN cord-023134-y665agnh 1108 20 . . . cord-023134-y665agnh 1109 1 The the DT cord-023134-y665agnh 1109 2 licensed licensed JJ cord-023134-y665agnh 1109 3 protocol protocol NN cord-023134-y665agnh 1109 4 was be VBD cord-023134-y665agnh 1109 5 used use VBN cord-023134-y665agnh 1109 6 : : : cord-023134-y665agnh 1109 7 3 3 CD cord-023134-y665agnh 1109 8 courses course NNS cord-023134-y665agnh 1109 9 of of IN cord-023134-y665agnh 1109 10 1MU 1mu CD cord-023134-y665agnh 1109 11 / / SYM cord-023134-y665agnh 1109 12 kg kg NNP cord-023134-y665agnh 1109 13 SC SC NNP cord-023134-y665agnh 1109 14 administered administer VBD cord-023134-y665agnh 1109 15 once once RB cord-023134-y665agnh 1109 16 daily daily RB cord-023134-y665agnh 1109 17 for for IN cord-023134-y665agnh 1109 18 5 5 CD cord-023134-y665agnh 1109 19 days day NNS cord-023134-y665agnh 1109 20 , , , cord-023134-y665agnh 1109 21 beginning begin VBG cord-023134-y665agnh 1109 22 on on IN cord-023134-y665agnh 1109 23 days day NNS cord-023134-y665agnh 1109 24 0 0 CD cord-023134-y665agnh 1109 25 , , , cord-023134-y665agnh 1109 26 14 14 CD cord-023134-y665agnh 1109 27 and and CC cord-023134-y665agnh 1109 28 60 60 CD cord-023134-y665agnh 1109 29 . . . cord-023134-y665agnh 1110 1 Blood blood NN cord-023134-y665agnh 1110 2 samples sample NNS cord-023134-y665agnh 1110 3 were be VBD cord-023134-y665agnh 1110 4 collected collect VBN cord-023134-y665agnh 1110 5 for for IN cord-023134-y665agnh 1110 6 SAA SAA NNP cord-023134-y665agnh 1110 7 , , , cord-023134-y665agnh 1110 8 AGP AGP NNP cord-023134-y665agnh 1110 9 and and CC cord-023134-y665agnh 1110 10 CRP CRP NNP cord-023134-y665agnh 1110 11 quantification quantification NN cord-023134-y665agnh 1110 12 before before RB cord-023134-y665agnh 1110 13 , , , cord-023134-y665agnh 1110 14 during during IN cord-023134-y665agnh 1110 15 and and CC cord-023134-y665agnh 1110 16 after after IN cord-023134-y665agnh 1110 17 treatment treatment NN cord-023134-y665agnh 1110 18 ( ( -LRB- cord-023134-y665agnh 1110 19 at at IN cord-023134-y665agnh 1110 20 D0 d0 NN cord-023134-y665agnh 1110 21 , , , cord-023134-y665agnh 1110 22 10 10 CD cord-023134-y665agnh 1110 23 , , , cord-023134-y665agnh 1110 24 30 30 CD cord-023134-y665agnh 1110 25 , , , cord-023134-y665agnh 1110 26 65 65 CD cord-023134-y665agnh 1110 27 ) ) -RRB- cord-023134-y665agnh 1110 28 . . . cord-023134-y665agnh 1111 1 SAA SAA NNP cord-023134-y665agnh 1111 2 was be VBD cord-023134-y665agnh 1111 3 quantified quantify VBN cord-023134-y665agnh 1111 4 by by IN cord-023134-y665agnh 1111 5 ELISA ELISA NNP cord-023134-y665agnh 1111 6 ( ( -LRB- cord-023134-y665agnh 1111 7 Phase Phase NNP cord-023134-y665agnh 1111 8 SAA SAA NNP cord-023134-y665agnh 1111 9 , , , cord-023134-y665agnh 1111 10 Tridelta Tridelta NNP cord-023134-y665agnh 1111 11 ) ) -RRB- cord-023134-y665agnh 1111 12 and and CC cord-023134-y665agnh 1112 1 AGP AGP NNP cord-023134-y665agnh 1112 2 was be VBD cord-023134-y665agnh 1112 3 determined determine VBN cord-023134-y665agnh 1112 4 by by IN cord-023134-y665agnh 1112 5 single single JJ cord-023134-y665agnh 1112 6 radial radial JJ cord-023134-y665agnh 1112 7 immunodifusion immunodifusion NN cord-023134-y665agnh 1112 8 ( ( -LRB- cord-023134-y665agnh 1112 9 AGP AGP NNP cord-023134-y665agnh 1112 10 , , , cord-023134-y665agnh 1112 11 Tridelta Tridelta NNP cord-023134-y665agnh 1112 12 ) ) -RRB- cord-023134-y665agnh 1112 13 . . . cord-023134-y665agnh 1113 1 Feline feline JJ cord-023134-y665agnh 1113 2 CRP CRP NNP cord-023134-y665agnh 1113 3 was be VBD cord-023134-y665agnh 1113 4 quantified quantify VBN cord-023134-y665agnh 1113 5 by by IN cord-023134-y665agnh 1113 6 ELISA ELISA NNP cord-023134-y665agnh 1113 7 ( ( -LRB- cord-023134-y665agnh 1113 8 Kamiya Kamiya NNP cord-023134-y665agnh 1113 9 Biomedical Biomedical NNP cord-023134-y665agnh 1113 10 Company).APP Company).APP NNP cord-023134-y665agnh 1113 11 serum serum NN cord-023134-y665agnh 1113 12 levels level NNS cord-023134-y665agnh 1113 13 were be VBD cord-023134-y665agnh 1113 14 compared compare VBN cord-023134-y665agnh 1113 15 before before IN cord-023134-y665agnh 1113 16 and and CC cord-023134-y665agnh 1113 17 after after IN cord-023134-y665agnh 1113 18 rFeIFN rFeIFN NNP cord-023134-y665agnh 1114 1 -x -x : cord-023134-y665agnh 1114 2 therapy therapy NN cord-023134-y665agnh 1114 3 . . . cord-023134-y665agnh 1115 1 A a DT cord-023134-y665agnh 1115 2 statistically statistically RB cord-023134-y665agnh 1115 3 significant significant JJ cord-023134-y665agnh 1115 4 increase increase NN cord-023134-y665agnh 1115 5 of of IN cord-023134-y665agnh 1115 6 SAA SAA NNP cord-023134-y665agnh 1115 7 and and CC cord-023134-y665agnh 1115 8 AGP AGP NNP cord-023134-y665agnh 1115 9 ( ( -LRB- cord-023134-y665agnh 1115 10 p=0.0005 p=0.0005 NNP cord-023134-y665agnh 1115 11 and and CC cord-023134-y665agnh 1115 12 p=0.012 p=0.012 NNP cord-023134-y665agnh 1116 1 respectively respectively RB cord-023134-y665agnh 1116 2 -Friedman -friedman JJ cord-023134-y665agnh 1116 3 test test NN cord-023134-y665agnh 1116 4 ) ) -RRB- cord-023134-y665agnh 1116 5 was be VBD cord-023134-y665agnh 1116 6 observed observe VBN cord-023134-y665agnh 1116 7 at at IN cord-023134-y665agnh 1116 8 D65 D65 NNP cord-023134-y665agnh 1116 9 in in IN cord-023134-y665agnh 1116 10 comparison comparison NN cord-023134-y665agnh 1116 11 to to IN cord-023134-y665agnh 1116 12 D0 D0 NNP cord-023134-y665agnh 1116 13 . . . cord-023134-y665agnh 1117 1 These these DT cord-023134-y665agnh 1117 2 findings finding NNS cord-023134-y665agnh 1117 3 corroborate corroborate VBP cord-023134-y665agnh 1117 4 the the DT cord-023134-y665agnh 1117 5 significant significant JJ cord-023134-y665agnh 1117 6 increase increase NN cord-023134-y665agnh 1117 7 of of IN cord-023134-y665agnh 1117 8 CRP crp NN cord-023134-y665agnh 1117 9 serum serum NN cord-023134-y665agnh 1117 10 levels level NNS cord-023134-y665agnh 1117 11 previously previously RB cord-023134-y665agnh 1117 12 described describe VBN cord-023134-y665agnh 1117 13 ( ( -LRB- cord-023134-y665agnh 1118 1 p p NN cord-023134-y665agnh 1118 2 < < XX cord-023134-y665agnh 1118 3 0.0001-Friedman 0.0001-friedman CD cord-023134-y665agnh 1119 1 test).All test).All NNP cord-023134-y665agnh 1119 2 the the DT cord-023134-y665agnh 1119 3 APPs app NNS cord-023134-y665agnh 1119 4 tested test VBN cord-023134-y665agnh 1119 5 behaved behave VBD cord-023134-y665agnh 1119 6 similarly similarly RB cord-023134-y665agnh 1119 7 , , , cord-023134-y665agnh 1119 8 showing show VBG cord-023134-y665agnh 1119 9 an an DT cord-023134-y665agnh 1119 10 evident evident JJ cord-023134-y665agnh 1119 11 increase increase NN cord-023134-y665agnh 1119 12 in in IN cord-023134-y665agnh 1119 13 their -PRON- PRP$ cord-023134-y665agnh 1119 14 serum serum NN cord-023134-y665agnh 1119 15 values value NNS cord-023134-y665agnh 1119 16 after after IN cord-023134-y665agnh 1119 17 rFeIFN rfeifn NN cord-023134-y665agnh 1119 18 - - HYPH cord-023134-y665agnh 1119 19 x x NN cord-023134-y665agnh 1119 20 therapy therapy NN cord-023134-y665agnh 1119 21 . . . cord-023134-y665agnh 1120 1 These these DT cord-023134-y665agnh 1120 2 results result NNS cord-023134-y665agnh 1120 3 suggest suggest VBP cord-023134-y665agnh 1120 4 a a DT cord-023134-y665agnh 1120 5 possible possible JJ cord-023134-y665agnh 1120 6 immune immune JJ cord-023134-y665agnh 1120 7 modulation modulation NN cord-023134-y665agnh 1120 8 effect effect NN cord-023134-y665agnh 1120 9 induced induce VBN cord-023134-y665agnh 1120 10 by by IN cord-023134-y665agnh 1120 11 rFeIFN rFeIFN NNP cord-023134-y665agnh 1120 12 - - HYPH cord-023134-y665agnh 1120 13 x x NN cord-023134-y665agnh 1120 14 which which WDT cord-023134-y665agnh 1120 15 seems seem VBZ cord-023134-y665agnh 1120 16 to to TO cord-023134-y665agnh 1120 17 maximize maximize VB cord-023134-y665agnh 1120 18 the the DT cord-023134-y665agnh 1120 19 efficiency efficiency NN cord-023134-y665agnh 1120 20 of of IN cord-023134-y665agnh 1120 21 innate innate JJ cord-023134-y665agnh 1120 22 immune immune JJ cord-023134-y665agnh 1120 23 response response NN cord-023134-y665agnh 1120 24 . . . cord-023134-y665agnh 1121 1 Further further JJ cord-023134-y665agnh 1121 2 studies study NNS cord-023134-y665agnh 1121 3 correlating correlate VBG cord-023134-y665agnh 1121 4 these these DT cord-023134-y665agnh 1121 5 findings finding NNS cord-023134-y665agnh 1121 6 with with IN cord-023134-y665agnh 1121 7 the the DT cord-023134-y665agnh 1121 8 cytokine cytokine NN cord-023134-y665agnh 1121 9 profile profile NN cord-023134-y665agnh 1121 10 will will MD cord-023134-y665agnh 1121 11 extend extend VB cord-023134-y665agnh 1121 12 our -PRON- PRP$ cord-023134-y665agnh 1121 13 knowledge knowledge NN cord-023134-y665agnh 1121 14 about about IN cord-023134-y665agnh 1121 15 the the DT cord-023134-y665agnh 1121 16 efficiency efficiency NN cord-023134-y665agnh 1121 17 of of IN cord-023134-y665agnh 1121 18 rFeIFN rfeifn NN cord-023134-y665agnh 1121 19 - - HYPH cord-023134-y665agnh 1121 20 x x NN cord-023134-y665agnh 1121 21 therapy therapy NN cord-023134-y665agnh 1121 22 in in IN cord-023134-y665agnh 1121 23 naturally naturally RB cord-023134-y665agnh 1121 24 retroviral retroviral JJ cord-023134-y665agnh 1121 25 infected infected JJ cord-023134-y665agnh 1121 26 cats cat NNS cord-023134-y665agnh 1121 27 . . . cord-023134-y665agnh 1122 1 Canine canine JJ cord-023134-y665agnh 1122 2 theileriosis theileriosis NN cord-023134-y665agnh 1122 3 is be VBZ cord-023134-y665agnh 1122 4 a a DT cord-023134-y665agnh 1122 5 tick tick NN cord-023134-y665agnh 1122 6 - - HYPH cord-023134-y665agnh 1122 7 born bear VBN cord-023134-y665agnh 1122 8 disease disease NN cord-023134-y665agnh 1122 9 caused cause VBN cord-023134-y665agnh 1122 10 by by IN cord-023134-y665agnh 1122 11 protozoan protozoan NN cord-023134-y665agnh 1122 12 parasites parasite NNS cord-023134-y665agnh 1122 13 of of IN cord-023134-y665agnh 1122 14 the the DT cord-023134-y665agnh 1122 15 genera genera NNP cord-023134-y665agnh 1122 16 Theileria Theileria NNP cord-023134-y665agnh 1122 17 that that WDT cord-023134-y665agnh 1122 18 has have VBZ cord-023134-y665agnh 1122 19 been be VBN cord-023134-y665agnh 1122 20 associated associate VBN cord-023134-y665agnh 1122 21 with with IN cord-023134-y665agnh 1122 22 anaemia anaemia NN cord-023134-y665agnh 1122 23 and/or and/or CC cord-023134-y665agnh 1122 24 thrombocytopaenia thrombocytopaenia NNP cord-023134-y665agnh 1122 25 . . . cord-023134-y665agnh 1123 1 The the DT cord-023134-y665agnh 1123 2 clinical clinical JJ cord-023134-y665agnh 1123 3 manifestation manifestation NN cord-023134-y665agnh 1123 4 of of IN cord-023134-y665agnh 1123 5 this this DT cord-023134-y665agnh 1123 6 disease disease NN cord-023134-y665agnh 1123 7 in in IN cord-023134-y665agnh 1123 8 the the DT cord-023134-y665agnh 1123 9 dog dog NN cord-023134-y665agnh 1123 10 is be VBZ cord-023134-y665agnh 1123 11 poorly poorly RB cord-023134-y665agnh 1123 12 described describe VBN cord-023134-y665agnh 1123 13 . . . cord-023134-y665agnh 1124 1 This this DT cord-023134-y665agnh 1124 2 disease disease NN cord-023134-y665agnh 1124 3 of of IN cord-023134-y665agnh 1124 4 emerging emerge VBG cord-023134-y665agnh 1124 5 importance importance NN cord-023134-y665agnh 1124 6 has have VBZ cord-023134-y665agnh 1124 7 been be VBN cord-023134-y665agnh 1124 8 diagnosed diagnose VBN cord-023134-y665agnh 1124 9 in in IN cord-023134-y665agnh 1124 10 several several JJ cord-023134-y665agnh 1124 11 dogs dog NNS cord-023134-y665agnh 1124 12 , , , cord-023134-y665agnh 1124 13 emphasizing emphasize VBG cord-023134-y665agnh 1124 14 the the DT cord-023134-y665agnh 1124 15 need need NN cord-023134-y665agnh 1124 16 to to TO cord-023134-y665agnh 1124 17 elucidate elucidate VB cord-023134-y665agnh 1124 18 the the DT cord-023134-y665agnh 1124 19 specific specific JJ cord-023134-y665agnh 1124 20 pathogenic pathogenic JJ cord-023134-y665agnh 1124 21 species specie NNS cord-023134-y665agnh 1124 22 and and CC cord-023134-y665agnh 1124 23 characterize characterize VB cord-023134-y665agnh 1124 24 the the DT cord-023134-y665agnh 1124 25 clinical clinical JJ cord-023134-y665agnh 1124 26 manifestations manifestation NNS cord-023134-y665agnh 1124 27 of of IN cord-023134-y665agnh 1124 28 the the DT cord-023134-y665agnh 1124 29 disease disease NN cord-023134-y665agnh 1124 30 . . . cord-023134-y665agnh 1125 1 This this DT cord-023134-y665agnh 1125 2 retrospective retrospective JJ cord-023134-y665agnh 1125 3 study study NN cord-023134-y665agnh 1125 4 describes describe VBZ cord-023134-y665agnh 1125 5 the the DT cord-023134-y665agnh 1125 6 clinical clinical JJ cord-023134-y665agnh 1125 7 characteristics characteristic NNS cord-023134-y665agnh 1125 8 , , , cord-023134-y665agnh 1125 9 diagnostic diagnostic JJ cord-023134-y665agnh 1125 10 tests test NNS cord-023134-y665agnh 1125 11 , , , cord-023134-y665agnh 1125 12 treatment treatment NN cord-023134-y665agnh 1125 13 and and CC cord-023134-y665agnh 1125 14 outcome outcome NN cord-023134-y665agnh 1125 15 of of IN cord-023134-y665agnh 1125 16 six six CD cord-023134-y665agnh 1125 17 client client NN cord-023134-y665agnh 1125 18 owned own VBN cord-023134-y665agnh 1125 19 clinically clinically RB cord-023134-y665agnh 1125 20 ill ill JJ cord-023134-y665agnh 1125 21 dogs dog NNS cord-023134-y665agnh 1125 22 diagnosed diagnose VBN cord-023134-y665agnh 1125 23 with with IN cord-023134-y665agnh 1125 24 canine canine JJ cord-023134-y665agnh 1125 25 theileriosis theileriosis NN cord-023134-y665agnh 1125 26 at at IN cord-023134-y665agnh 1125 27 the the DT cord-023134-y665agnh 1125 28 Onderstepoort Onderstepoort NNP cord-023134-y665agnh 1125 29 Veterinary Veterinary NNP cord-023134-y665agnh 1125 30 Academic Academic NNP cord-023134-y665agnh 1125 31 Hospital Hospital NNP cord-023134-y665agnh 1125 32 in in IN cord-023134-y665agnh 1125 33 South South NNP cord-023134-y665agnh 1125 34 Africa Africa NNP cord-023134-y665agnh 1125 35 during during IN cord-023134-y665agnh 1125 36 2010 2010 CD cord-023134-y665agnh 1125 37 - - SYM cord-023134-y665agnh 1125 38 2011 2011 CD cord-023134-y665agnh 1125 39 . . . cord-023134-y665agnh 1126 1 Canine canine JJ cord-023134-y665agnh 1126 2 theileriosis theileriosis NN cord-023134-y665agnh 1126 3 was be VBD cord-023134-y665agnh 1126 4 diagnosed diagnose VBN cord-023134-y665agnh 1126 5 by by IN cord-023134-y665agnh 1126 6 Polymerase Polymerase NNP cord-023134-y665agnh 1126 7 Chain Chain NNP cord-023134-y665agnh 1126 8 Reaction reaction NN cord-023134-y665agnh 1126 9 ( ( -LRB- cord-023134-y665agnh 1126 10 PCR PCR NNP cord-023134-y665agnh 1126 11 ) ) -RRB- cord-023134-y665agnh 1126 12 on on IN cord-023134-y665agnh 1126 13 whole whole JJ cord-023134-y665agnh 1126 14 - - HYPH cord-023134-y665agnh 1126 15 blood blood NN cord-023134-y665agnh 1126 16 followed follow VBN cord-023134-y665agnh 1126 17 by by IN cord-023134-y665agnh 1126 18 a a DT cord-023134-y665agnh 1126 19 Reverse reverse JJ cord-023134-y665agnh 1126 20 Line line NN cord-023134-y665agnh 1126 21 Blot blot NN cord-023134-y665agnh 1126 22 ( ( -LRB- cord-023134-y665agnh 1126 23 RLB rlb NN cord-023134-y665agnh 1126 24 ) ) -RRB- cord-023134-y665agnh 1126 25 hybridization hybridization NN cord-023134-y665agnh 1126 26 assay assay NN cord-023134-y665agnh 1126 27 . . . cord-023134-y665agnh 1127 1 Other other JJ cord-023134-y665agnh 1127 2 tickborn tickborn NN cord-023134-y665agnh 1127 3 diseases disease NNS cord-023134-y665agnh 1127 4 and and CC cord-023134-y665agnh 1127 5 neoplastic neoplastic JJ cord-023134-y665agnh 1127 6 conditions condition NNS cord-023134-y665agnh 1127 7 were be VBD cord-023134-y665agnh 1127 8 excluded exclude VBN cord-023134-y665agnh 1127 9 . . . cord-023134-y665agnh 1128 1 The the DT cord-023134-y665agnh 1128 2 most most RBS cord-023134-y665agnh 1128 3 common common JJ cord-023134-y665agnh 1128 4 clinical clinical JJ cord-023134-y665agnh 1128 5 findings finding NNS cord-023134-y665agnh 1128 6 were be VBD cord-023134-y665agnh 1128 7 pale pale JJ cord-023134-y665agnh 1128 8 mucous mucous JJ cord-023134-y665agnh 1128 9 membranes membrane NNS cord-023134-y665agnh 1128 10 ( ( -LRB- cord-023134-y665agnh 1128 11 5/6 5/6 CD cord-023134-y665agnh 1128 12 dogs dog NNS cord-023134-y665agnh 1128 13 ) ) -RRB- cord-023134-y665agnh 1128 14 , , , cord-023134-y665agnh 1128 15 lethargy lethargy NN cord-023134-y665agnh 1128 16 ( ( -LRB- cord-023134-y665agnh 1128 17 3/6 3/6 CD cord-023134-y665agnh 1128 18 dogs dog NNS cord-023134-y665agnh 1128 19 ) ) -RRB- cord-023134-y665agnh 1128 20 and and CC cord-023134-y665agnh 1128 21 oral oral JJ cord-023134-y665agnh 1128 22 bleeding bleeding NN cord-023134-y665agnh 1128 23 ( ( -LRB- cord-023134-y665agnh 1128 24 3/6 3/6 CD cord-023134-y665agnh 1128 25 dogs dog NNS cord-023134-y665agnh 1128 26 ) ) -RRB- cord-023134-y665agnh 1128 27 . . . cord-023134-y665agnh 1129 1 All all DT cord-023134-y665agnh 1129 2 dogs dog NNS cord-023134-y665agnh 1129 3 had have VBD cord-023134-y665agnh 1129 4 thrombocytopaenia thrombocytopaenia NNP cord-023134-y665agnh 1129 5 with with IN cord-023134-y665agnh 1129 6 a a DT cord-023134-y665agnh 1129 7 median median NN cord-023134-y665agnh 1129 8 of of IN cord-023134-y665agnh 1129 9 59.5 59.5 CD cord-023134-y665agnh 1129 10 x x SYM cord-023134-y665agnh 1129 11 10 10 CD cord-023134-y665agnh 1129 12 9 9 CD cord-023134-y665agnh 1129 13 /l /l NN cord-023134-y665agnh 1129 14 ( ( -LRB- cord-023134-y665agnh 1129 15 range range NN cord-023134-y665agnh 1129 16 : : : cord-023134-y665agnh 1129 17 13 13 CD cord-023134-y665agnh 1129 18 -199 -199 NNS cord-023134-y665agnh 1129 19 ) ) -RRB- cord-023134-y665agnh 1129 20 and and CC cord-023134-y665agnh 1129 21 5/6 5/6 CD cord-023134-y665agnh 1129 22 dogs dog NNS cord-023134-y665agnh 1129 23 had have VBD cord-023134-y665agnh 1129 24 anaemia anaemia NN cord-023134-y665agnh 1129 25 with with IN cord-023134-y665agnh 1129 26 a a DT cord-023134-y665agnh 1129 27 median median JJ cord-023134-y665agnh 1129 28 haematocrit haematocrit NN cord-023134-y665agnh 1129 29 of of IN cord-023134-y665agnh 1129 30 18 18 CD cord-023134-y665agnh 1129 31 % % NN cord-023134-y665agnh 1130 1 ( ( -LRB- cord-023134-y665agnh 1130 2 range range NN cord-023134-y665agnh 1130 3 : : : cord-023134-y665agnh 1130 4 5 5 CD cord-023134-y665agnh 1130 5 -32 -32 NN cord-023134-y665agnh 1130 6 ) ) -RRB- cord-023134-y665agnh 1130 7 . . . cord-023134-y665agnh 1131 1 The the DT cord-023134-y665agnh 1131 2 anaemia anaemia NN cord-023134-y665agnh 1131 3 was be VBD cord-023134-y665agnh 1131 4 regenerative regenerative JJ cord-023134-y665agnh 1131 5 in in IN cord-023134-y665agnh 1131 6 3/5 3/5 CD cord-023134-y665agnh 1131 7 dogs dog NNS cord-023134-y665agnh 1131 8 and and CC cord-023134-y665agnh 1131 9 non non JJ cord-023134-y665agnh 1131 10 - - JJ cord-023134-y665agnh 1131 11 regenerative regenerative JJ cord-023134-y665agnh 1131 12 in in IN cord-023134-y665agnh 1131 13 2/5 2/5 CD cord-023134-y665agnh 1131 14 dogs dog NNS cord-023134-y665agnh 1131 15 . . . cord-023134-y665agnh 1132 1 One one CD cord-023134-y665agnh 1132 2 dog dog NN cord-023134-y665agnh 1132 3 was be VBD cord-023134-y665agnh 1132 4 positive positive JJ cord-023134-y665agnh 1132 5 on on IN cord-023134-y665agnh 1132 6 an an DT cord-023134-y665agnh 1132 7 in in IN cord-023134-y665agnh 1132 8 saline saline NN cord-023134-y665agnh 1132 9 auto auto NN cord-023134-y665agnh 1132 10 - - HYPH cord-023134-y665agnh 1132 11 agglutination agglutination NN cord-023134-y665agnh 1132 12 test test NN cord-023134-y665agnh 1132 13 . . . cord-023134-y665agnh 1133 1 Bone bone NN cord-023134-y665agnh 1133 2 marrow marrow NN cord-023134-y665agnh 1133 3 cytology cytology NN cord-023134-y665agnh 1133 4 and and CC cord-023134-y665agnh 1133 5 core core NN cord-023134-y665agnh 1133 6 biopsies biopsy NNS cord-023134-y665agnh 1133 7 were be VBD cord-023134-y665agnh 1133 8 performed perform VBN cord-023134-y665agnh 1133 9 in in IN cord-023134-y665agnh 1133 10 two two CD cord-023134-y665agnh 1133 11 dogs dog NNS cord-023134-y665agnh 1133 12 with with IN cord-023134-y665agnh 1133 13 severe severe JJ cord-023134-y665agnh 1133 14 non non JJ cord-023134-y665agnh 1133 15 - - JJ cord-023134-y665agnh 1133 16 regenerative regenerative JJ cord-023134-y665agnh 1133 17 anaemia anaemia NN cord-023134-y665agnh 1133 18 and and CC cord-023134-y665agnh 1133 19 showed show VBD cord-023134-y665agnh 1133 20 myelofibrosis myelofibrosis NNP cord-023134-y665agnh 1133 21 . . . cord-023134-y665agnh 1134 1 Theileriasp Theileriasp NNP cord-023134-y665agnh 1134 2 . . . cord-023134-y665agnh 1135 1 were be VBD cord-023134-y665agnh 1135 2 detected detect VBN cord-023134-y665agnh 1135 3 in in IN cord-023134-y665agnh 1135 4 four four CD cord-023134-y665agnh 1135 5 dogs dog NNS cord-023134-y665agnh 1135 6 and and CC cord-023134-y665agnh 1135 7 Theileria Theileria NNP cord-023134-y665agnh 1135 8 equi equi NN cord-023134-y665agnh 1135 9 in in IN cord-023134-y665agnh 1135 10 two two CD cord-023134-y665agnh 1135 11 dogs dog NNS cord-023134-y665agnh 1135 12 . . . cord-023134-y665agnh 1136 1 Imidocarb Imidocarb NNP cord-023134-y665agnh 1136 2 dipropionate dipropionate NNP cord-023134-y665agnh 1136 3 was be VBD cord-023134-y665agnh 1136 4 administered administer VBN cord-023134-y665agnh 1136 5 in in IN cord-023134-y665agnh 1136 6 all all DT cord-023134-y665agnh 1136 7 dogs dog NNS cord-023134-y665agnh 1136 8 as as IN cord-023134-y665agnh 1136 9 treatment treatment NN cord-023134-y665agnh 1136 10 of of IN cord-023134-y665agnh 1136 11 choice choice NN cord-023134-y665agnh 1136 12 for for IN cord-023134-y665agnh 1136 13 the the DT cord-023134-y665agnh 1136 14 theileriosis theileriosis NN cord-023134-y665agnh 1136 15 . . . cord-023134-y665agnh 1137 1 Five five CD cord-023134-y665agnh 1137 2 dogs dog NNS cord-023134-y665agnh 1137 3 that that WDT cord-023134-y665agnh 1137 4 received receive VBD cord-023134-y665agnh 1137 5 the the DT cord-023134-y665agnh 1137 6 complete complete JJ cord-023134-y665agnh 1137 7 treatment treatment NN cord-023134-y665agnh 1137 8 achieved achieve VBD cord-023134-y665agnh 1137 9 clinical clinical JJ cord-023134-y665agnh 1137 10 cure cure NN cord-023134-y665agnh 1137 11 . . . cord-023134-y665agnh 1138 1 PCR PCR NNP cord-023134-y665agnh 1138 2 post post NN cord-023134-y665agnh 1138 3 - - NN cord-023134-y665agnh 1138 4 treatment treatment NN cord-023134-y665agnh 1138 5 was be VBD cord-023134-y665agnh 1138 6 performed perform VBN cord-023134-y665agnh 1138 7 in in IN cord-023134-y665agnh 1138 8 three three CD cord-023134-y665agnh 1138 9 dogs dog NNS cord-023134-y665agnh 1138 10 and and CC cord-023134-y665agnh 1138 11 was be VBD cord-023134-y665agnh 1138 12 negative negative JJ cord-023134-y665agnh 1138 13 . . . cord-023134-y665agnh 1139 1 Prednisolone prednisolone NN cord-023134-y665agnh 1139 2 and and CC cord-023134-y665agnh 1139 3 azathioprine azathioprine NN cord-023134-y665agnh 1139 4 was be VBD cord-023134-y665agnh 1139 5 administered administer VBN cord-023134-y665agnh 1139 6 in in IN cord-023134-y665agnh 1139 7 all all DT cord-023134-y665agnh 1139 8 dogs dog NNS cord-023134-y665agnh 1139 9 for for IN cord-023134-y665agnh 1139 10 suspected suspect VBN cord-023134-y665agnh 1139 11 immune immune NN cord-023134-y665agnh 1139 12 - - HYPH cord-023134-y665agnh 1139 13 mediated mediate VBN cord-023134-y665agnh 1139 14 haematological haematological JJ cord-023134-y665agnh 1139 15 disorders disorder NNS cord-023134-y665agnh 1139 16 secondary secondary JJ cord-023134-y665agnh 1139 17 to to IN cord-023134-y665agnh 1139 18 the the DT cord-023134-y665agnh 1139 19 theileriosis theileriosis NN cord-023134-y665agnh 1139 20 . . . cord-023134-y665agnh 1140 1 One one CD cord-023134-y665agnh 1140 2 dog dog NN cord-023134-y665agnh 1140 3 was be VBD cord-023134-y665agnh 1140 4 euthanased euthanase VBN cord-023134-y665agnh 1140 5 one one CD cord-023134-y665agnh 1140 6 week week NN cord-023134-y665agnh 1140 7 after after IN cord-023134-y665agnh 1140 8 diagnosis diagnosis NN cord-023134-y665agnh 1140 9 . . . cord-023134-y665agnh 1141 1 Canine canine JJ cord-023134-y665agnh 1141 2 theileriosis theileriosis NN cord-023134-y665agnh 1141 3 should should MD cord-023134-y665agnh 1141 4 be be VB cord-023134-y665agnh 1141 5 considered consider VBN cord-023134-y665agnh 1141 6 a a DT cord-023134-y665agnh 1141 7 differential differential JJ cord-023134-y665agnh 1141 8 diagnosis diagnosis NN cord-023134-y665agnh 1141 9 for for IN cord-023134-y665agnh 1141 10 dogs dog NNS cord-023134-y665agnh 1141 11 with with IN cord-023134-y665agnh 1141 12 thrombocytopaenia thrombocytopaenia NNP cord-023134-y665agnh 1141 13 and/or and/or CC cord-023134-y665agnh 1141 14 anaemia anaemia NN cord-023134-y665agnh 1141 15 in in IN cord-023134-y665agnh 1141 16 endemic endemic JJ cord-023134-y665agnh 1141 17 tick tick NN cord-023134-y665agnh 1141 18 - - HYPH cord-023134-y665agnh 1141 19 born bear VBN cord-023134-y665agnh 1141 20 disease disease NN cord-023134-y665agnh 1141 21 areas area NNS cord-023134-y665agnh 1141 22 . . . cord-023134-y665agnh 1142 1 PCR PCR NNP cord-023134-y665agnh 1142 2 is be VBZ cord-023134-y665agnh 1142 3 a a DT cord-023134-y665agnh 1142 4 versatile versatile JJ cord-023134-y665agnh 1142 5 tool tool NN cord-023134-y665agnh 1142 6 for for IN cord-023134-y665agnh 1142 7 diagnosis diagnosis NN cord-023134-y665agnh 1142 8 and and CC cord-023134-y665agnh 1142 9 treatment treatment NN cord-023134-y665agnh 1142 10 monitoring monitoring NN cord-023134-y665agnh 1142 11 in in IN cord-023134-y665agnh 1142 12 theileriosis theileriosis NNP cord-023134-y665agnh 1142 13 . . . cord-023134-y665agnh 1143 1 In in IN cord-023134-y665agnh 1143 2 our -PRON- PRP$ cord-023134-y665agnh 1143 3 study study NN cord-023134-y665agnh 1143 4 , , , cord-023134-y665agnh 1143 5 imidocarb imidocarb NNP cord-023134-y665agnh 1143 6 dipropionate dipropionate NNP cord-023134-y665agnh 1143 7 was be VBD cord-023134-y665agnh 1143 8 effective effective JJ cord-023134-y665agnh 1143 9 in in IN cord-023134-y665agnh 1143 10 sterilizing sterilize VBG cord-023134-y665agnh 1143 11 the the DT cord-023134-y665agnh 1143 12 parasitic parasitic JJ cord-023134-y665agnh 1143 13 infection infection NN cord-023134-y665agnh 1143 14 . . . cord-023134-y665agnh 1144 1 The the DT cord-023134-y665agnh 1144 2 bleeding bleeding JJ cord-023134-y665agnh 1144 3 tendency tendency NN cord-023134-y665agnh 1144 4 seen see VBN cord-023134-y665agnh 1144 5 in in IN cord-023134-y665agnh 1144 6 the the DT cord-023134-y665agnh 1144 7 theileriosis theileriosis NN cord-023134-y665agnh 1144 8 cases case NNS cord-023134-y665agnh 1144 9 is be VBZ cord-023134-y665agnh 1144 10 most most RBS cord-023134-y665agnh 1144 11 likely likely RB cord-023134-y665agnh 1144 12 secondary secondary JJ cord-023134-y665agnh 1144 13 to to IN cord-023134-y665agnh 1144 14 the the DT cord-023134-y665agnh 1144 15 thrombocytopaenia thrombocytopaenia NNP cord-023134-y665agnh 1144 16 and/or and/or CC cord-023134-y665agnh 1144 17 concurrent concurrent JJ cord-023134-y665agnh 1144 18 thrombocytopathy thrombocytopathy NNP cord-023134-y665agnh 1144 19 as as IN cord-023134-y665agnh 1144 20 described describe VBN cord-023134-y665agnh 1144 21 in in IN cord-023134-y665agnh 1144 22 canine canine JJ cord-023134-y665agnh 1144 23 ehrlichiosis ehrlichiosis NN cord-023134-y665agnh 1144 24 . . . cord-023134-y665agnh 1145 1 Further further JJ cord-023134-y665agnh 1145 2 studies study NNS cord-023134-y665agnh 1145 3 are be VBP cord-023134-y665agnh 1145 4 required require VBN cord-023134-y665agnh 1145 5 to to TO cord-023134-y665agnh 1145 6 determine determine VB cord-023134-y665agnh 1145 7 the the DT cord-023134-y665agnh 1145 8 possible possible JJ cord-023134-y665agnh 1145 9 links link NNS cord-023134-y665agnh 1145 10 between between IN cord-023134-y665agnh 1145 11 thrombocytopaenia thrombocytopaenia NNP cord-023134-y665agnh 1145 12 , , , cord-023134-y665agnh 1145 13 anaemia anaemia NN cord-023134-y665agnh 1145 14 and and CC cord-023134-y665agnh 1145 15 myeloproliferative myeloproliferative JJ cord-023134-y665agnh 1145 16 disorder disorder NN cord-023134-y665agnh 1145 17 observed observe VBN cord-023134-y665agnh 1145 18 in in IN cord-023134-y665agnh 1145 19 canine canine JJ cord-023134-y665agnh 1145 20 theileriosis theileriosis NN cord-023134-y665agnh 1145 21 . . . cord-023134-y665agnh 1146 1 A.L. A.L. NNP cord-023134-y665agnh 1146 2 Proksch Proksch NNP cord-023134-y665agnh 1146 3 1 1 CD cord-023134-y665agnh 1146 4 , , , cord-023134-y665agnh 1146 5 S. S. NNP cord-023134-y665agnh 1146 6 Unterer Unterer NNP cord-023134-y665agnh 1146 7 1 1 CD cord-023134-y665agnh 1146 8 , , , cord-023134-y665agnh 1146 9 U. U. NNP cord-023134-y665agnh 1146 10 Truyen Truyen NNP cord-023134-y665agnh 1146 11 2 2 CD cord-023134-y665agnh 1146 12 , , , cord-023134-y665agnh 1146 13 R.S. R.S. NNP cord-023134-y665agnh 1146 14 Mueller Mueller NNP cord-023134-y665agnh 1146 15 1 1 CD cord-023134-y665agnh 1146 16 , , , cord-023134-y665agnh 1146 17 K. K. NNP cord-023134-y665agnh 1146 18 Hartmann Hartmann NNP cord-023134-y665agnh 1146 19 1 1 CD cord-023134-y665agnh 1146 20 . . . cord-023134-y665agnh 1147 1 1 1 CD cord-023134-y665agnh 1147 2 Clinic Clinic NNP cord-023134-y665agnh 1147 3 of of IN cord-023134-y665agnh 1147 4 Small Small NNP cord-023134-y665agnh 1147 5 Animal Animal NNP cord-023134-y665agnh 1147 6 Medicine Medicine NNP cord-023134-y665agnh 1147 7 , , , cord-023134-y665agnh 1147 8 LMU LMU NNP cord-023134-y665agnh 1147 9 University University NNP cord-023134-y665agnh 1147 10 of of IN cord-023134-y665agnh 1147 11 Munich Munich NNP cord-023134-y665agnh 1147 12 , , , cord-023134-y665agnh 1147 13 MUNICH MUNICH NNP cord-023134-y665agnh 1147 14 , , , cord-023134-y665agnh 1147 15 Germany Germany NNP cord-023134-y665agnh 1147 16 , , , cord-023134-y665agnh 1147 17 2 2 CD cord-023134-y665agnh 1147 18 Institute Institute NNP cord-023134-y665agnh 1147 19 for for IN cord-023134-y665agnh 1147 20 Animal Animal NNP cord-023134-y665agnh 1147 21 Hygiene Hygiene NNP cord-023134-y665agnh 1147 22 and and CC cord-023134-y665agnh 1147 23 Veterinary Veterinary NNP cord-023134-y665agnh 1147 24 Public Public NNP cord-023134-y665agnh 1147 25 Health Health NNP cord-023134-y665agnh 1147 26 , , , cord-023134-y665agnh 1147 27 University University NNP cord-023134-y665agnh 1147 28 of of IN cord-023134-y665agnh 1147 29 Leipzig Leipzig NNP cord-023134-y665agnh 1147 30 , , , cord-023134-y665agnh 1147 31 LEIPZIG LEIPZIG NNP cord-023134-y665agnh 1147 32 , , , cord-023134-y665agnh 1147 33 Germany Germany NNP cord-023134-y665agnh 1147 34 Canine canine JJ cord-023134-y665agnh 1147 35 parvovirosis parvovirosis NN cord-023134-y665agnh 1147 36 still still RB cord-023134-y665agnh 1147 37 is be VBZ cord-023134-y665agnh 1147 38 a a DT cord-023134-y665agnh 1147 39 common common JJ cord-023134-y665agnh 1147 40 and and CC cord-023134-y665agnh 1147 41 severe severe JJ cord-023134-y665agnh 1147 42 disease disease NN cord-023134-y665agnh 1147 43 , , , cord-023134-y665agnh 1147 44 especially especially RB cord-023134-y665agnh 1147 45 in in IN cord-023134-y665agnh 1147 46 puppies puppy NNS cord-023134-y665agnh 1147 47 , , , cord-023134-y665agnh 1147 48 and and CC cord-023134-y665agnh 1147 49 there there EX cord-023134-y665agnh 1147 50 is be VBZ cord-023134-y665agnh 1147 51 a a DT cord-023134-y665agnh 1147 52 need need NN cord-023134-y665agnh 1147 53 for for IN cord-023134-y665agnh 1147 54 drugs drug NNS cord-023134-y665agnh 1147 55 that that WDT cord-023134-y665agnh 1147 56 can can MD cord-023134-y665agnh 1147 57 decrease decrease VB cord-023134-y665agnh 1147 58 severity severity NN cord-023134-y665agnh 1147 59 of of IN cord-023134-y665agnh 1147 60 symptoms symptom NNS cord-023134-y665agnh 1147 61 and and CC cord-023134-y665agnh 1147 62 accelerate accelerate VB cord-023134-y665agnh 1147 63 recovery recovery NN cord-023134-y665agnh 1147 64 . . . cord-023134-y665agnh 1148 1 The the DT cord-023134-y665agnh 1148 2 paramunity paramunity NN cord-023134-y665agnh 1148 3 inducer inducer NN cord-023134-y665agnh 1148 4 PIND PIND NNP cord-023134-y665agnh 1148 5 - - HYPH cord-023134-y665agnh 1148 6 ORF ORF NNP cord-023134-y665agnh 1148 7 stimulates stimulate VBZ cord-023134-y665agnh 1148 8 the the DT cord-023134-y665agnh 1148 9 immune immune JJ cord-023134-y665agnh 1148 10 system system NN cord-023134-y665agnh 1148 11 . . . cord-023134-y665agnh 1149 1 Therefore therefore RB cord-023134-y665agnh 1149 2 , , , cord-023134-y665agnh 1149 3 the the DT cord-023134-y665agnh 1149 4 aim aim NN cord-023134-y665agnh 1149 5 of of IN cord-023134-y665agnh 1149 6 the the DT cord-023134-y665agnh 1149 7 study study NN cord-023134-y665agnh 1149 8 was be VBD cord-023134-y665agnh 1149 9 to to TO cord-023134-y665agnh 1149 10 investigate investigate VB cord-023134-y665agnh 1149 11 whether whether IN cord-023134-y665agnh 1149 12 PIND PIND NNP cord-023134-y665agnh 1149 13 - - HYPH cord-023134-y665agnh 1149 14 ORF ORF NNP cord-023134-y665agnh 1149 15 , , , cord-023134-y665agnh 1149 16 used use VBD cord-023134-y665agnh 1149 17 as as IN cord-023134-y665agnh 1149 18 an an DT cord-023134-y665agnh 1149 19 additional additional JJ cord-023134-y665agnh 1149 20 drug drug NN cord-023134-y665agnh 1149 21 , , , cord-023134-y665agnh 1149 22 leads lead VBZ cord-023134-y665agnh 1149 23 to to IN cord-023134-y665agnh 1149 24 faster fast JJR cord-023134-y665agnh 1149 25 recovery recovery NN cord-023134-y665agnh 1149 26 in in IN cord-023134-y665agnh 1149 27 dogs dog NNS cord-023134-y665agnh 1149 28 with with IN cord-023134-y665agnh 1149 29 parvovirosis parvovirosis NN cord-023134-y665agnh 1149 30 . . . cord-023134-y665agnh 1150 1 In in IN cord-023134-y665agnh 1150 2 total total NN cord-023134-y665agnh 1150 3 , , , cord-023134-y665agnh 1150 4 40 40 CD cord-023134-y665agnh 1150 5 dogs dog NNS cord-023134-y665agnh 1150 6 with with IN cord-023134-y665agnh 1150 7 parvovirosis parvovirosis NN cord-023134-y665agnh 1150 8 were be VBD cord-023134-y665agnh 1150 9 randomly randomly RB cord-023134-y665agnh 1150 10 assigned assign VBN cord-023134-y665agnh 1150 11 to to IN cord-023134-y665agnh 1150 12 two two CD cord-023134-y665agnh 1150 13 groups group NNS cord-023134-y665agnh 1150 14 ( ( -LRB- cord-023134-y665agnh 1150 15 20 20 CD cord-023134-y665agnh 1150 16 dogs dog NNS cord-023134-y665agnh 1150 17 each each DT cord-023134-y665agnh 1150 18 ) ) -RRB- cord-023134-y665agnh 1150 19 . . . cord-023134-y665agnh 1151 1 In in IN cord-023134-y665agnh 1151 2 all all DT cord-023134-y665agnh 1151 3 dogs dog NNS cord-023134-y665agnh 1151 4 , , , cord-023134-y665agnh 1151 5 infection infection NN cord-023134-y665agnh 1151 6 with with IN cord-023134-y665agnh 1151 7 canine canine JJ cord-023134-y665agnh 1151 8 parvovirus parvovirus NN cord-023134-y665agnh 1151 9 was be VBD cord-023134-y665agnh 1151 10 diagnosed diagnose VBN cord-023134-y665agnh 1151 11 by by IN cord-023134-y665agnh 1151 12 fecal fecal JJ cord-023134-y665agnh 1151 13 ELISA ELISA NNP cord-023134-y665agnh 1151 14 or or CC cord-023134-y665agnh 1151 15 polymerase polymerase NN cord-023134-y665agnh 1151 16 chain chain NN cord-023134-y665agnh 1151 17 reaction reaction NN cord-023134-y665agnh 1151 18 ( ( -LRB- cord-023134-y665agnh 1151 19 PCR PCR NNP cord-023134-y665agnh 1151 20 ) ) -RRB- cord-023134-y665agnh 1151 21 . . . cord-023134-y665agnh 1152 1 Also also RB cord-023134-y665agnh 1152 2 , , , cord-023134-y665agnh 1152 3 all all DT cord-023134-y665agnh 1152 4 dogs dog NNS cord-023134-y665agnh 1152 5 had have VBD cord-023134-y665agnh 1152 6 clinical clinical JJ cord-023134-y665agnh 1152 7 signs sign NNS cord-023134-y665agnh 1152 8 . . . cord-023134-y665agnh 1153 1 The the DT cord-023134-y665agnh 1153 2 study study NN cord-023134-y665agnh 1153 3 was be VBD cord-023134-y665agnh 1153 4 performed perform VBN cord-023134-y665agnh 1153 5 as as IN cord-023134-y665agnh 1153 6 prospective prospective JJ cord-023134-y665agnh 1153 7 placebo placebo NN cord-023134-y665agnh 1153 8 - - HYPH cord-023134-y665agnh 1153 9 controlled control VBN cord-023134-y665agnh 1153 10 , , , cord-023134-y665agnh 1153 11 double double RB cord-023134-y665agnh 1153 12 - - HYPH cord-023134-y665agnh 1153 13 blinded blinded JJ cord-023134-y665agnh 1153 14 trial trial NN cord-023134-y665agnh 1153 15 . . . cord-023134-y665agnh 1154 1 All all DT cord-023134-y665agnh 1154 2 dogs dog NNS cord-023134-y665agnh 1154 3 received receive VBD cord-023134-y665agnh 1154 4 either either CC cord-023134-y665agnh 1154 5 PIND PIND NNP cord-023134-y665agnh 1154 6 - - HYPH cord-023134-y665agnh 1154 7 ORF ORF NNP cord-023134-y665agnh 1154 8 or or CC cord-023134-y665agnh 1154 9 placebo placebo NN cord-023134-y665agnh 1154 10 , , , cord-023134-y665agnh 1154 11 and and CC cord-023134-y665agnh 1154 12 additional additional JJ cord-023134-y665agnh 1154 13 standardized standardized JJ cord-023134-y665agnh 1154 14 treatment treatment NN cord-023134-y665agnh 1154 15 for for IN cord-023134-y665agnh 1154 16 canine canine JJ cord-023134-y665agnh 1154 17 parvovirosis parvovirosis NN cord-023134-y665agnh 1154 18 . . . cord-023134-y665agnh 1155 1 Clinical clinical JJ cord-023134-y665agnh 1155 2 scores score NNS cord-023134-y665agnh 1155 3 , , , cord-023134-y665agnh 1155 4 complete complete JJ cord-023134-y665agnh 1155 5 blood blood NN cord-023134-y665agnh 1155 6 count count NN cord-023134-y665agnh 1155 7 , , , cord-023134-y665agnh 1155 8 and and CC cord-023134-y665agnh 1155 9 serum serum NN cord-023134-y665agnh 1155 10 protein protein NN cord-023134-y665agnh 1155 11 and and CC cord-023134-y665agnh 1155 12 albumin albumin NN cord-023134-y665agnh 1155 13 were be VBD cord-023134-y665agnh 1155 14 evaluated evaluate VBN cord-023134-y665agnh 1155 15 daily daily RB cord-023134-y665agnh 1155 16 ( ( -LRB- cord-023134-y665agnh 1155 17 day day NN cord-023134-y665agnh 1155 18 0 0 CD cord-023134-y665agnh 1155 19 -7 -7 CD cord-023134-y665agnh 1155 20 ) ) -RRB- cord-023134-y665agnh 1155 21 and and CC cord-023134-y665agnh 1155 22 at at IN cord-023134-y665agnh 1155 23 day day NN cord-023134-y665agnh 1155 24 14 14 CD cord-023134-y665agnh 1155 25 . . . cord-023134-y665agnh 1156 1 Viral viral JJ cord-023134-y665agnh 1156 2 shedding shedding NN cord-023134-y665agnh 1156 3 was be VBD cord-023134-y665agnh 1156 4 measured measure VBN cord-023134-y665agnh 1156 5 on on IN cord-023134-y665agnh 1156 6 day day NN cord-023134-y665agnh 1156 7 0 0 CD cord-023134-y665agnh 1156 8 , , , cord-023134-y665agnh 1156 9 3 3 CD cord-023134-y665agnh 1156 10 , , , cord-023134-y665agnh 1156 11 7 7 CD cord-023134-y665agnh 1156 12 , , , cord-023134-y665agnh 1156 13 and and CC cord-023134-y665agnh 1156 14 14 14 CD cord-023134-y665agnh 1156 15 by by IN cord-023134-y665agnh 1156 16 fecal fecal JJ cord-023134-y665agnh 1156 17 PCR PCR NNP cord-023134-y665agnh 1156 18 and and CC cord-023134-y665agnh 1156 19 virus virus NN cord-023134-y665agnh 1156 20 isolation isolation NN cord-023134-y665agnh 1156 21 . . . cord-023134-y665agnh 1157 1 No no DT cord-023134-y665agnh 1157 2 significant significant JJ cord-023134-y665agnh 1157 3 difference difference NN cord-023134-y665agnh 1157 4 could could MD cord-023134-y665agnh 1157 5 be be VB cord-023134-y665agnh 1157 6 found find VBN cord-023134-y665agnh 1157 7 in in IN cord-023134-y665agnh 1157 8 clinical clinical JJ cord-023134-y665agnh 1157 9 scores score NNS cord-023134-y665agnh 1157 10 , , , cord-023134-y665agnh 1157 11 most most JJS cord-023134-y665agnh 1157 12 blood blood NN cord-023134-y665agnh 1157 13 parameters parameter NNS cord-023134-y665agnh 1157 14 , , , cord-023134-y665agnh 1157 15 and and CC cord-023134-y665agnh 1157 16 duration duration NN cord-023134-y665agnh 1157 17 of of IN cord-023134-y665agnh 1157 18 virus virus NN cord-023134-y665agnh 1157 19 shedding shed VBG cord-023134-y665agnh 1157 20 when when WRB cord-023134-y665agnh 1157 21 comparing compare VBG cord-023134-y665agnh 1157 22 dogs dog NNS cord-023134-y665agnh 1157 23 receiving receive VBG cord-023134-y665agnh 1157 24 PIND PIND NNP cord-023134-y665agnh 1157 25 - - HYPH cord-023134-y665agnh 1157 26 ORF ORF NNP cord-023134-y665agnh 1157 27 and and CC cord-023134-y665agnh 1157 28 dogs dog NNS cord-023134-y665agnh 1157 29 receiving receive VBG cord-023134-y665agnh 1157 30 placebo placebo NN cord-023134-y665agnh 1157 31 . . . cord-023134-y665agnh 1158 1 The the DT cord-023134-y665agnh 1158 2 only only JJ cord-023134-y665agnh 1158 3 significant significant JJ cord-023134-y665agnh 1158 4 difference difference NN cord-023134-y665agnh 1158 5 was be VBD cord-023134-y665agnh 1158 6 an an DT cord-023134-y665agnh 1158 7 increase increase NN cord-023134-y665agnh 1158 8 in in IN cord-023134-y665agnh 1158 9 lymphocyte lymphocyte NN cord-023134-y665agnh 1158 10 counts count NNS cord-023134-y665agnh 1158 11 observed observe VBN cord-023134-y665agnh 1158 12 in in IN cord-023134-y665agnh 1158 13 the the DT cord-023134-y665agnh 1158 14 PIND PIND NNP cord-023134-y665agnh 1158 15 - - HYPH cord-023134-y665agnh 1158 16 ORF ORF NNP cord-023134-y665agnh 1158 17 group group NN cord-023134-y665agnh 1158 18 . . . cord-023134-y665agnh 1159 1 Three three CD cord-023134-y665agnh 1159 2 dogs dog NNS cord-023134-y665agnh 1159 3 receiving receive VBG cord-023134-y665agnh 1159 4 placebo placebo NN cord-023134-y665agnh 1159 5 did do VBD cord-023134-y665agnh 1159 6 not not RB cord-023134-y665agnh 1159 7 survive survive VB cord-023134-y665agnh 1159 8 , , , cord-023134-y665agnh 1159 9 but but CC cord-023134-y665agnh 1159 10 no no DT cord-023134-y665agnh 1159 11 significant significant JJ cord-023134-y665agnh 1159 12 difference difference NN cord-023134-y665agnh 1159 13 between between IN cord-023134-y665agnh 1159 14 groups group NNS cord-023134-y665agnh 1159 15 was be VBD cord-023134-y665agnh 1159 16 determined determine VBN cord-023134-y665agnh 1159 17 concerning concern VBG cord-023134-y665agnh 1159 18 survival survival NN cord-023134-y665agnh 1159 19 rate rate NN cord-023134-y665agnh 1159 20 . . . cord-023134-y665agnh 1160 1 In in IN cord-023134-y665agnh 1160 2 this this DT cord-023134-y665agnh 1160 3 study study NN cord-023134-y665agnh 1160 4 , , , cord-023134-y665agnh 1160 5 no no DT cord-023134-y665agnh 1160 6 significant significant JJ cord-023134-y665agnh 1160 7 influence influence NN cord-023134-y665agnh 1160 8 of of IN cord-023134-y665agnh 1160 9 the the DT cord-023134-y665agnh 1160 10 paramunity paramunity NN cord-023134-y665agnh 1160 11 inducer inducer NN cord-023134-y665agnh 1160 12 PIND PIND NNP cord-023134-y665agnh 1160 13 - - HYPH cord-023134-y665agnh 1160 14 ORF ORF NNP cord-023134-y665agnh 1160 15 on on IN cord-023134-y665agnh 1160 16 the the DT cord-023134-y665agnh 1160 17 course course NN cord-023134-y665agnh 1160 18 of of IN cord-023134-y665agnh 1160 19 parvovirosis parvovirosis NN cord-023134-y665agnh 1160 20 was be VBD cord-023134-y665agnh 1160 21 determined determine VBN cord-023134-y665agnh 1160 22 . . . cord-023134-y665agnh 1161 1 Therefore therefore RB cord-023134-y665agnh 1161 2 , , , cord-023134-y665agnh 1161 3 there there EX cord-023134-y665agnh 1161 4 is be VBZ cord-023134-y665agnh 1161 5 no no DT cord-023134-y665agnh 1161 6 indication indication NN cord-023134-y665agnh 1161 7 to to TO cord-023134-y665agnh 1161 8 recommend recommend VB cord-023134-y665agnh 1161 9 PIND PIND NNP cord-023134-y665agnh 1161 10 - - HYPH cord-023134-y665agnh 1161 11 ORF ORF NNP cord-023134-y665agnh 1161 12 therapy therapy NN cord-023134-y665agnh 1161 13 in in IN cord-023134-y665agnh 1161 14 canine canine JJ cord-023134-y665agnh 1161 15 parvovirosis parvovirosis NN cord-023134-y665agnh 1161 16 . . . cord-023134-y665agnh 1162 1 The the DT cord-023134-y665agnh 1162 2 Microscopic Microscopic NNP cord-023134-y665agnh 1162 3 Agglutination agglutination NN cord-023134-y665agnh 1162 4 Test test NN cord-023134-y665agnh 1162 5 ( ( -LRB- cord-023134-y665agnh 1162 6 MAT MAT NNP cord-023134-y665agnh 1162 7 ) ) -RRB- cord-023134-y665agnh 1162 8 is be VBZ cord-023134-y665agnh 1162 9 currently currently RB cord-023134-y665agnh 1162 10 considered consider VBN cord-023134-y665agnh 1162 11 as as IN cord-023134-y665agnh 1162 12 the the DT cord-023134-y665agnh 1162 13 gold gold NN cord-023134-y665agnh 1162 14 standard standard NN cord-023134-y665agnh 1162 15 for for IN cord-023134-y665agnh 1162 16 the the DT cord-023134-y665agnh 1162 17 diagnosis diagnosis NN cord-023134-y665agnh 1162 18 of of IN cord-023134-y665agnh 1162 19 leptospirosis leptospirosis NN cord-023134-y665agnh 1162 20 in in IN cord-023134-y665agnh 1162 21 dogs dog NNS cord-023134-y665agnh 1162 22 . . . cord-023134-y665agnh 1163 1 However however RB cord-023134-y665agnh 1163 2 , , , cord-023134-y665agnh 1163 3 it -PRON- PRP cord-023134-y665agnh 1163 4 is be VBZ cord-023134-y665agnh 1163 5 not not RB cord-023134-y665agnh 1163 6 a a DT cord-023134-y665agnh 1163 7 perfect perfect JJ cord-023134-y665agnh 1163 8 tool tool NN cord-023134-y665agnh 1163 9 to to TO cord-023134-y665agnh 1163 10 predict predict VB cord-023134-y665agnh 1163 11 the the DT cord-023134-y665agnh 1163 12 infecting infect VBG cord-023134-y665agnh 1163 13 serogroup serogroup NN cord-023134-y665agnh 1163 14 as as IN cord-023134-y665agnh 1163 15 cross cross NN cord-023134-y665agnh 1163 16 - - NNS cord-023134-y665agnh 1163 17 reactions reaction NNS cord-023134-y665agnh 1163 18 and and CC cord-023134-y665agnh 1163 19 paradoxical paradoxical JJ cord-023134-y665agnh 1163 20 reactions reaction NNS cord-023134-y665agnh 1163 21 do do VBP cord-023134-y665agnh 1163 22 exist exist VB cord-023134-y665agnh 1163 23 . . . cord-023134-y665agnh 1164 1 The the DT cord-023134-y665agnh 1164 2 objective objective NN cord-023134-y665agnh 1164 3 of of IN cord-023134-y665agnh 1164 4 this this DT cord-023134-y665agnh 1164 5 study study NN cord-023134-y665agnh 1164 6 was be VBD cord-023134-y665agnh 1164 7 to to TO cord-023134-y665agnh 1164 8 determine determine VB cord-023134-y665agnh 1164 9 the the DT cord-023134-y665agnh 1164 10 infecting infect VBG cord-023134-y665agnh 1164 11 serovar serovar NNP cord-023134-y665agnh 1164 12 in in IN cord-023134-y665agnh 1164 13 29 29 CD cord-023134-y665agnh 1164 14 dogs dog NNS cord-023134-y665agnh 1164 15 with with IN cord-023134-y665agnh 1164 16 a a DT cord-023134-y665agnh 1164 17 positive positive JJ cord-023134-y665agnh 1164 18 Polymerase Polymerase NNP cord-023134-y665agnh 1164 19 Chain Chain NNP cord-023134-y665agnh 1164 20 Reaction reaction NN cord-023134-y665agnh 1164 21 ( ( -LRB- cord-023134-y665agnh 1164 22 PCR PCR NNP cord-023134-y665agnh 1164 23 ) ) -RRB- cord-023134-y665agnh 1164 24 on on IN cord-023134-y665agnh 1164 25 one one CD cord-023134-y665agnh 1164 26 or or CC cord-023134-y665agnh 1164 27 more more JJR cord-023134-y665agnh 1164 28 biological biological JJ cord-023134-y665agnh 1164 29 sample(s sample(s NNP cord-023134-y665agnh 1164 30 ) ) -RRB- cord-023134-y665agnh 1164 31 by by IN cord-023134-y665agnh 1164 32 molecular molecular JJ cord-023134-y665agnh 1164 33 typing typing NN cord-023134-y665agnh 1164 34 and and CC cord-023134-y665agnh 1164 35 to to TO cord-023134-y665agnh 1164 36 compare compare VB cord-023134-y665agnh 1164 37 the the DT cord-023134-y665agnh 1164 38 results result NNS cord-023134-y665agnh 1164 39 with with IN cord-023134-y665agnh 1164 40 those those DT cord-023134-y665agnh 1164 41 provided provide VBN cord-023134-y665agnh 1164 42 by by IN cord-023134-y665agnh 1164 43 the the DT cord-023134-y665agnh 1164 44 highest high JJS cord-023134-y665agnh 1164 45 MAT MAT NNP cord-023134-y665agnh 1164 46 titer titer NN cord-023134-y665agnh 1164 47 for for IN cord-023134-y665agnh 1164 48 each each DT cord-023134-y665agnh 1164 49 dog dog NN cord-023134-y665agnh 1164 50 . . . cord-023134-y665agnh 1165 1 Forty forty CD cord-023134-y665agnh 1165 2 - - HYPH cord-023134-y665agnh 1165 3 one one CD cord-023134-y665agnh 1165 4 positive positive JJ cord-023134-y665agnh 1165 5 PCR PCR NNP cord-023134-y665agnh 1165 6 biological biological JJ cord-023134-y665agnh 1165 7 samples sample NNS cord-023134-y665agnh 1165 8 ( ( -LRB- cord-023134-y665agnh 1165 9 20 20 CD cord-023134-y665agnh 1165 10 urine urine NN cord-023134-y665agnh 1165 11 samples sample NNS cord-023134-y665agnh 1165 12 , , , cord-023134-y665agnh 1165 13 19 19 CD cord-023134-y665agnh 1165 14 blood blood NN cord-023134-y665agnh 1165 15 samples sample NNS cord-023134-y665agnh 1165 16 , , , cord-023134-y665agnh 1165 17 one one CD cord-023134-y665agnh 1165 18 kidney kidney NN cord-023134-y665agnh 1165 19 sample sample NN cord-023134-y665agnh 1165 20 and and CC cord-023134-y665agnh 1165 21 one one CD cord-023134-y665agnh 1165 22 cerebrospinal cerebrospinal JJ cord-023134-y665agnh 1165 23 fluid fluid NN cord-023134-y665agnh 1165 24 -CSF -CSF : cord-023134-y665agnh 1165 25 - - HYPH cord-023134-y665agnh 1165 26 sample sample NN cord-023134-y665agnh 1165 27 ) ) -RRB- cord-023134-y665agnh 1165 28 from from IN cord-023134-y665agnh 1165 29 29 29 CD cord-023134-y665agnh 1165 30 dogs dog NNS cord-023134-y665agnh 1165 31 with with IN cord-023134-y665agnh 1165 32 a a DT cord-023134-y665agnh 1165 33 clinical clinical JJ cord-023134-y665agnh 1165 34 suspicion suspicion NN cord-023134-y665agnh 1165 35 of of IN cord-023134-y665agnh 1165 36 leptospirosis leptospirosis NN cord-023134-y665agnh 1165 37 between between IN cord-023134-y665agnh 1165 38 2008 2008 CD cord-023134-y665agnh 1165 39 and and CC cord-023134-y665agnh 1165 40 2011 2011 CD cord-023134-y665agnh 1165 41 and and CC cord-023134-y665agnh 1166 1 at at RB cord-023134-y665agnh 1166 2 least least RBS cord-023134-y665agnh 1166 3 one one CD cord-023134-y665agnh 1166 4 positive positive JJ cord-023134-y665agnh 1166 5 PCR pcr NN cord-023134-y665agnh 1166 6 on on IN cord-023134-y665agnh 1166 7 blood blood NN cord-023134-y665agnh 1166 8 , , , cord-023134-y665agnh 1166 9 urine urine NN cord-023134-y665agnh 1166 10 , , , cord-023134-y665agnh 1166 11 kidney kidney NN cord-023134-y665agnh 1166 12 or or CC cord-023134-y665agnh 1166 13 CSF CSF NNP cord-023134-y665agnh 1166 14 ( ( -LRB- cord-023134-y665agnh 1166 15 Kit Kit NNP cord-023134-y665agnh 1166 16 Taqvet Taqvet NNP cord-023134-y665agnh 1166 17 Pathogenic Pathogenic NNP cord-023134-y665agnh 1166 18 Leptospira Leptospira NNP cord-023134-y665agnh 1166 19 , , , cord-023134-y665agnh 1166 20 LSI LSI NNP cord-023134-y665agnh 1166 21 , , , cord-023134-y665agnh 1166 22 France France NNP cord-023134-y665agnh 1166 23 ) ) -RRB- cord-023134-y665agnh 1166 24 were be VBD cord-023134-y665agnh 1166 25 submitted submit VBN cord-023134-y665agnh 1166 26 to to IN cord-023134-y665agnh 1166 27 molecular molecular JJ cord-023134-y665agnh 1166 28 typing typing NN cord-023134-y665agnh 1166 29 . . . cord-023134-y665agnh 1167 1 The the DT cord-023134-y665agnh 1167 2 genomospecies genomospecie NNS cord-023134-y665agnh 1167 3 were be VBD cord-023134-y665agnh 1167 4 first first RB cord-023134-y665agnh 1167 5 determined determine VBN cord-023134-y665agnh 1167 6 by by IN cord-023134-y665agnh 1167 7 partial partial JJ cord-023134-y665agnh 1167 8 rpoB rpoB NNS cord-023134-y665agnh 1167 9 or or CC cord-023134-y665agnh 1167 10 partial partial JJ cord-023134-y665agnh 1167 11 16S 16S NNP cord-023134-y665agnh 1167 12 rRNA rrna NN cord-023134-y665agnh 1167 13 gene gene NN cord-023134-y665agnh 1167 14 sequencing sequencing NN cord-023134-y665agnh 1167 15 . . . cord-023134-y665agnh 1168 1 The the DT cord-023134-y665agnh 1168 2 serovar serovar NN cord-023134-y665agnh 1168 3 was be VBD cord-023134-y665agnh 1168 4 further further RB cord-023134-y665agnh 1168 5 identified identify VBN cord-023134-y665agnh 1168 6 by by IN cord-023134-y665agnh 1168 7 Multiple multiple JJ cord-023134-y665agnh 1168 8 Loci Loci NNP cord-023134-y665agnh 1168 9 Variable Variable NNP cord-023134-y665agnh 1168 10 Number number NN cord-023134-y665agnh 1168 11 Tandem Tandem NNP cord-023134-y665agnh 1168 12 Repeat Repeat NNP cord-023134-y665agnh 1168 13 Analysis Analysis NNP cord-023134-y665agnh 1168 14 ( ( -LRB- cord-023134-y665agnh 1168 15 MLVA MLVA NNP cord-023134-y665agnh 1168 16 ) ) -RRB- cord-023134-y665agnh 1168 17 . . . cord-023134-y665agnh 1169 1 Three three CD cord-023134-y665agnh 1169 2 Variable variable JJ cord-023134-y665agnh 1169 3 Number number NN cord-023134-y665agnh 1169 4 Tandem Tandem NNP cord-023134-y665agnh 1169 5 Repeat repeat NN cord-023134-y665agnh 1169 6 ( ( -LRB- cord-023134-y665agnh 1169 7 VNTR vntr NN cord-023134-y665agnh 1169 8 ) ) -RRB- cord-023134-y665agnh 1169 9 loci locus NNS cord-023134-y665agnh 1169 10 were be VBD cord-023134-y665agnh 1169 11 used use VBN cord-023134-y665agnh 1169 12 as as IN cord-023134-y665agnh 1169 13 markers marker NNS cord-023134-y665agnh 1169 14 for for IN cord-023134-y665agnh 1169 15 serovar serovar NNP cord-023134-y665agnh 1169 16 identification identification NN cord-023134-y665agnh 1169 17 . . . cord-023134-y665agnh 1170 1 The the DT cord-023134-y665agnh 1170 2 genomospecies genomospecie NNS cord-023134-y665agnh 1170 3 were be VBD cord-023134-y665agnh 1170 4 Leptospira Leptospira NNP cord-023134-y665agnh 1170 5 interrogans interrogan NNS cord-023134-y665agnh 1170 6 sensu sensu NNP cord-023134-y665agnh 1170 7 stricto stricto NNP cord-023134-y665agnh 1170 8 in in IN cord-023134-y665agnh 1170 9 36 36 CD cord-023134-y665agnh 1170 10 samples sample NNS cord-023134-y665agnh 1170 11 belonging belong VBG cord-023134-y665agnh 1170 12 to to IN cord-023134-y665agnh 1170 13 25 25 CD cord-023134-y665agnh 1170 14 dogs dog NNS cord-023134-y665agnh 1170 15 , , , cord-023134-y665agnh 1170 16 Leptospira Leptospira NNP cord-023134-y665agnh 1170 17 borgpetersenii borgpetersenii NN cord-023134-y665agnh 1170 18 in in IN cord-023134-y665agnh 1170 19 three three CD cord-023134-y665agnh 1170 20 samples sample NNS cord-023134-y665agnh 1170 21 ( ( -LRB- cord-023134-y665agnh 1170 22 three three CD cord-023134-y665agnh 1170 23 dogs dog NNS cord-023134-y665agnh 1170 24 ) ) -RRB- cord-023134-y665agnh 1170 25 and and CC cord-023134-y665agnh 1170 26 Leptospira Leptospira NNP cord-023134-y665agnh 1170 27 kirschneri kirschneri NN cord-023134-y665agnh 1170 28 in in IN cord-023134-y665agnh 1170 29 two two CD cord-023134-y665agnh 1170 30 samples sample NNS cord-023134-y665agnh 1170 31 ( ( -LRB- cord-023134-y665agnh 1170 32 two two CD cord-023134-y665agnh 1170 33 dogs dog NNS cord-023134-y665agnh 1170 34 ) ) -RRB- cord-023134-y665agnh 1170 35 . . . cord-023134-y665agnh 1171 1 Interestingly interestingly RB cord-023134-y665agnh 1171 2 , , , cord-023134-y665agnh 1171 3 for for IN cord-023134-y665agnh 1171 4 one one CD cord-023134-y665agnh 1171 5 dog dog NN cord-023134-y665agnh 1171 6 , , , cord-023134-y665agnh 1171 7 we -PRON- PRP cord-023134-y665agnh 1171 8 found find VBD cord-023134-y665agnh 1171 9 a a DT cord-023134-y665agnh 1171 10 different different JJ cord-023134-y665agnh 1171 11 species specie NNS cord-023134-y665agnh 1171 12 in in IN cord-023134-y665agnh 1171 13 the the DT cord-023134-y665agnh 1171 14 blood blood NN cord-023134-y665agnh 1171 15 and and CC cord-023134-y665agnh 1171 16 in in IN cord-023134-y665agnh 1171 17 the the DT cord-023134-y665agnh 1171 18 urine urine NN cord-023134-y665agnh 1171 19 . . . cord-023134-y665agnh 1172 1 MLVA MLVA NNP cord-023134-y665agnh 1172 2 could could MD cord-023134-y665agnh 1172 3 unequivocally unequivocally RB cord-023134-y665agnh 1172 4 determine determine VB cord-023134-y665agnh 1172 5 infecting infect VBG cord-023134-y665agnh 1172 6 serovar serovar NNP cord-023134-y665agnh 1172 7 in in IN cord-023134-y665agnh 1172 8 14 14 CD cord-023134-y665agnh 1172 9 samples sample NNS cord-023134-y665agnh 1172 10 belonging belong VBG cord-023134-y665agnh 1172 11 to to IN cord-023134-y665agnh 1172 12 13 13 CD cord-023134-y665agnh 1172 13 dogs dog NNS cord-023134-y665agnh 1172 14 : : : cord-023134-y665agnh 1172 15 Australis australis NN cord-023134-y665agnh 1172 16 in in IN cord-023134-y665agnh 1172 17 one one CD cord-023134-y665agnh 1172 18 dog dog NN cord-023134-y665agnh 1172 19 , , , cord-023134-y665agnh 1172 20 Muenchen Muenchen NNP cord-023134-y665agnh 1172 21 in in IN cord-023134-y665agnh 1172 22 three three CD cord-023134-y665agnh 1172 23 dogs dog NNS cord-023134-y665agnh 1172 24 , , , cord-023134-y665agnh 1172 25 Fugis Fugis NNP cord-023134-y665agnh 1172 26 in in IN cord-023134-y665agnh 1172 27 one one CD cord-023134-y665agnh 1172 28 dog dog NN cord-023134-y665agnh 1172 29 , , , cord-023134-y665agnh 1172 30 Canicola Canicola NNP cord-023134-y665agnh 1172 31 in in IN cord-023134-y665agnh 1172 32 two two CD cord-023134-y665agnh 1172 33 dogs dog NNS cord-023134-y665agnh 1172 34 , , , cord-023134-y665agnh 1172 35 Autumnalis Autumnalis NNP cord-023134-y665agnh 1172 36 in in IN cord-023134-y665agnh 1172 37 six six CD cord-023134-y665agnh 1172 38 dogs dog NNS cord-023134-y665agnh 1172 39 . . . cord-023134-y665agnh 1173 1 For for IN cord-023134-y665agnh 1173 2 only only RB cord-023134-y665agnh 1173 3 two two CD cord-023134-y665agnh 1173 4 dogs dog NNS cord-023134-y665agnh 1173 5 among among IN cord-023134-y665agnh 1173 6 those those DT cord-023134-y665agnh 1173 7 13 13 CD cord-023134-y665agnh 1173 8 , , , cord-023134-y665agnh 1173 9 the the DT cord-023134-y665agnh 1173 10 infecting infect VBG cord-023134-y665agnh 1173 11 serovar serovar NNS cord-023134-y665agnh 1173 12 identified identify VBN cord-023134-y665agnh 1173 13 by by IN cord-023134-y665agnh 1173 14 MLVA MLVA NNP cord-023134-y665agnh 1173 15 belonged belong VBD cord-023134-y665agnh 1173 16 to to IN cord-023134-y665agnh 1173 17 the the DT cord-023134-y665agnh 1173 18 infecting infect VBG cord-023134-y665agnh 1173 19 serogroup serogroup NN cord-023134-y665agnh 1173 20 identified identify VBN cord-023134-y665agnh 1173 21 by by IN cord-023134-y665agnh 1173 22 MAT MAT NNP cord-023134-y665agnh 1173 23 . . . cord-023134-y665agnh 1174 1 For for IN cord-023134-y665agnh 1174 2 16 16 CD cord-023134-y665agnh 1174 3 samples sample NNS cord-023134-y665agnh 1174 4 belonging belong VBG cord-023134-y665agnh 1174 5 to to IN cord-023134-y665agnh 1174 6 15 15 CD cord-023134-y665agnh 1174 7 dogs dog NNS cord-023134-y665agnh 1174 8 , , , cord-023134-y665agnh 1174 9 MLVA MLVA NNP cord-023134-y665agnh 1174 10 failed fail VBD cord-023134-y665agnh 1174 11 to to TO cord-023134-y665agnh 1174 12 identify identify VB cord-023134-y665agnh 1174 13 the the DT cord-023134-y665agnh 1174 14 infecting infect VBG cord-023134-y665agnh 1174 15 serovar serovar NNP cord-023134-y665agnh 1174 16 because because IN cord-023134-y665agnh 1174 17 one one CD cord-023134-y665agnh 1174 18 or or CC cord-023134-y665agnh 1174 19 more more JJR cord-023134-y665agnh 1174 20 marker(s marker(s NNP cord-023134-y665agnh 1174 21 ) ) -RRB- cord-023134-y665agnh 1174 22 could could MD cord-023134-y665agnh 1174 23 not not RB cord-023134-y665agnh 1174 24 be be VB cord-023134-y665agnh 1174 25 amplified amplify VBN cord-023134-y665agnh 1174 26 . . . cord-023134-y665agnh 1175 1 For for IN cord-023134-y665agnh 1175 2 11 11 CD cord-023134-y665agnh 1175 3 samples sample NNS cord-023134-y665agnh 1175 4 belonging belong VBG cord-023134-y665agnh 1175 5 to to IN cord-023134-y665agnh 1175 6 9 9 CD cord-023134-y665agnh 1175 7 dogs dog NNS cord-023134-y665agnh 1175 8 , , , cord-023134-y665agnh 1175 9 amplification amplification NN cord-023134-y665agnh 1175 10 profile profile NN cord-023134-y665agnh 1175 11 suggested suggest VBD cord-023134-y665agnh 1175 12 coinfection coinfection NN cord-023134-y665agnh 1175 13 or or CC cord-023134-y665agnh 1175 14 infection infection NN cord-023134-y665agnh 1175 15 with with IN cord-023134-y665agnh 1175 16 a a DT cord-023134-y665agnh 1175 17 serovar serovar NN cord-023134-y665agnh 1175 18 that that WDT cord-023134-y665agnh 1175 19 had have VBD cord-023134-y665agnh 1175 20 not not RB cord-023134-y665agnh 1175 21 been be VBN cord-023134-y665agnh 1175 22 previously previously RB cord-023134-y665agnh 1175 23 characterized characterize VBN cord-023134-y665agnh 1175 24 by by IN cord-023134-y665agnh 1175 25 MLVA MLVA NNP cord-023134-y665agnh 1175 26 . . . cord-023134-y665agnh 1176 1 It -PRON- PRP cord-023134-y665agnh 1176 2 must must MD cord-023134-y665agnh 1176 3 be be VB cord-023134-y665agnh 1176 4 noted note VBN cord-023134-y665agnh 1176 5 that that IN cord-023134-y665agnh 1176 6 for for IN cord-023134-y665agnh 1176 7 some some DT cord-023134-y665agnh 1176 8 dogs dog NNS cord-023134-y665agnh 1176 9 , , , cord-023134-y665agnh 1176 10 we -PRON- PRP cord-023134-y665agnh 1176 11 were be VBD cord-023134-y665agnh 1176 12 able able JJ cord-023134-y665agnh 1176 13 to to TO cord-023134-y665agnh 1176 14 characterize characterize VB cord-023134-y665agnh 1176 15 the the DT cord-023134-y665agnh 1176 16 serovar serovar NNP cord-023134-y665agnh 1176 17 in in IN cord-023134-y665agnh 1176 18 a a DT cord-023134-y665agnh 1176 19 single single JJ cord-023134-y665agnh 1176 20 kind kind NN cord-023134-y665agnh 1176 21 of of IN cord-023134-y665agnh 1176 22 sample sample NN cord-023134-y665agnh 1176 23 . . . cord-023134-y665agnh 1177 1 Despite despite IN cord-023134-y665agnh 1177 2 lack lack NN cord-023134-y665agnh 1177 3 of of IN cord-023134-y665agnh 1177 4 sensitivity sensitivity NN cord-023134-y665agnh 1177 5 of of IN cord-023134-y665agnh 1177 6 MLVA MLVA NNP cord-023134-y665agnh 1177 7 applied apply VBD cord-023134-y665agnh 1177 8 to to IN cord-023134-y665agnh 1177 9 clinical clinical JJ cord-023134-y665agnh 1177 10 strains strain NNS cord-023134-y665agnh 1177 11 in in IN cord-023134-y665agnh 1177 12 our -PRON- PRP$ cord-023134-y665agnh 1177 13 study study NN cord-023134-y665agnh 1177 14 , , , cord-023134-y665agnh 1177 15 this this DT cord-023134-y665agnh 1177 16 rapid rapid JJ cord-023134-y665agnh 1177 17 method method NN cord-023134-y665agnh 1177 18 could could MD cord-023134-y665agnh 1177 19 contribute contribute VB cord-023134-y665agnh 1177 20 to to IN cord-023134-y665agnh 1177 21 a a DT cord-023134-y665agnh 1177 22 better well JJR cord-023134-y665agnh 1177 23 knowledge knowledge NN cord-023134-y665agnh 1177 24 of of IN cord-023134-y665agnh 1177 25 the the DT cord-023134-y665agnh 1177 26 epidemiology epidemiology NN cord-023134-y665agnh 1177 27 of of IN cord-023134-y665agnh 1177 28 canine canine JJ cord-023134-y665agnh 1177 29 leptospirosis leptospirosis NN cord-023134-y665agnh 1177 30 with with IN cord-023134-y665agnh 1177 31 some some DT cord-023134-y665agnh 1177 32 adaptations adaptation NNS cord-023134-y665agnh 1177 33 in in IN cord-023134-y665agnh 1177 34 the the DT cord-023134-y665agnh 1177 35 choice choice NN cord-023134-y665agnh 1177 36 of of IN cord-023134-y665agnh 1177 37 markers marker NNS cord-023134-y665agnh 1177 38 . . . cord-023134-y665agnh 1178 1 Recently recently RB cord-023134-y665agnh 1178 2 , , , cord-023134-y665agnh 1178 3 two two CD cord-023134-y665agnh 1178 4 Trichomonads trichomonad NNS cord-023134-y665agnh 1178 5 have have VBP cord-023134-y665agnh 1178 6 been be VBN cord-023134-y665agnh 1178 7 identified identify VBN cord-023134-y665agnh 1178 8 in in IN cord-023134-y665agnh 1178 9 diarrheal diarrheal JJ cord-023134-y665agnh 1178 10 stool stool NN cord-023134-y665agnh 1178 11 of of IN cord-023134-y665agnh 1178 12 puppies puppy NNS cord-023134-y665agnh 1178 13 : : : cord-023134-y665agnh 1178 14 PentatrichomonasHominis PentatrichomonasHominis NNP cord-023134-y665agnh 1178 15 ( ( -LRB- cord-023134-y665agnh 1178 16 PH PH NNP cord-023134-y665agnh 1178 17 ) ) -RRB- cord-023134-y665agnh 1178 18 and and CC cord-023134-y665agnh 1178 19 Tritrichomonas Tritrichomonas NNP cord-023134-y665agnh 1178 20 foetus foetus NN cord-023134-y665agnh 1178 21 ( ( -LRB- cord-023134-y665agnh 1178 22 TF TF NNP cord-023134-y665agnh 1178 23 ) ) -RRB- cord-023134-y665agnh 1178 24 [ [ -LRB- cord-023134-y665agnh 1178 25 1 1 CD cord-023134-y665agnh 1178 26 ] ] -RRB- cord-023134-y665agnh 1178 27 . . . cord-023134-y665agnh 1179 1 TF TF NNP cord-023134-y665agnh 1179 2 infection infection NN cord-023134-y665agnh 1179 3 in in IN cord-023134-y665agnh 1179 4 cats cat NNS cord-023134-y665agnh 1179 5 results result VBZ cord-023134-y665agnh 1179 6 in in IN cord-023134-y665agnh 1179 7 a a DT cord-023134-y665agnh 1179 8 chronic chronic JJ cord-023134-y665agnh 1179 9 colitis colitis NN cord-023134-y665agnh 1179 10 . . . cord-023134-y665agnh 1180 1 However however RB cord-023134-y665agnh 1180 2 in in IN cord-023134-y665agnh 1180 3 dogs dog NNS cord-023134-y665agnh 1180 4 , , , cord-023134-y665agnh 1180 5 pathogenicity pathogenicity NN cord-023134-y665agnh 1180 6 of of IN cord-023134-y665agnh 1180 7 TF TF NNP cord-023134-y665agnh 1180 8 and and CC cord-023134-y665agnh 1180 9 PH PH NNP cord-023134-y665agnh 1180 10 has have VBZ cord-023134-y665agnh 1180 11 never never RB cord-023134-y665agnh 1180 12 been be VBN cord-023134-y665agnh 1180 13 studied study VBN cord-023134-y665agnh 1180 14 . . . cord-023134-y665agnh 1181 1 So so RB cord-023134-y665agnh 1181 2 the the DT cord-023134-y665agnh 1181 3 objective objective NN cord-023134-y665agnh 1181 4 of of IN cord-023134-y665agnh 1181 5 this this DT cord-023134-y665agnh 1181 6 study study NN cord-023134-y665agnh 1181 7 was be VBD cord-023134-y665agnh 1181 8 to to TO cord-023134-y665agnh 1181 9 evaluate evaluate VB cord-023134-y665agnh 1181 10 the the DT cord-023134-y665agnh 1181 11 association association NN cord-023134-y665agnh 1181 12 between between IN cord-023134-y665agnh 1181 13 Trichomonads Trichomonads NNP cord-023134-y665agnh 1181 14 ' ' POS cord-023134-y665agnh 1181 15 infection infection NN cord-023134-y665agnh 1181 16 in in IN cord-023134-y665agnh 1181 17 puppies puppy NNS cord-023134-y665agnh 1181 18 and and CC cord-023134-y665agnh 1181 19 the the DT cord-023134-y665agnh 1181 20 presence presence NN cord-023134-y665agnh 1181 21 of of IN cord-023134-y665agnh 1181 22 diarrhea diarrhea NN cord-023134-y665agnh 1181 23 . . . cord-023134-y665agnh 1182 1 Faecal Faecal NNP cord-023134-y665agnh 1182 2 samples sample NNS cord-023134-y665agnh 1182 3 were be VBD cord-023134-y665agnh 1182 4 collected collect VBN cord-023134-y665agnh 1182 5 prospectively prospectively RB cord-023134-y665agnh 1182 6 from from IN cord-023134-y665agnh 1182 7 273 273 CD cord-023134-y665agnh 1182 8 puppies puppy NNS cord-023134-y665agnh 1182 9 ( ( -LRB- cord-023134-y665agnh 1182 10 4 4 CD cord-023134-y665agnh 1182 11 to to TO cord-023134-y665agnh 1182 12 13 13 CD cord-023134-y665agnh 1182 13 weeks week NNS cord-023134-y665agnh 1182 14 of of IN cord-023134-y665agnh 1182 15 age age NN cord-023134-y665agnh 1182 16 ) ) -RRB- cord-023134-y665agnh 1182 17 in in IN cord-023134-y665agnh 1182 18 3 3 CD cord-023134-y665agnh 1182 19 French french JJ cord-023134-y665agnh 1182 20 breeding breeding NN cord-023134-y665agnh 1182 21 kennels kennel NNS cord-023134-y665agnh 1182 22 . . . cord-023134-y665agnh 1183 1 For for IN cord-023134-y665agnh 1183 2 each each DT cord-023134-y665agnh 1183 3 puppy puppy NN cord-023134-y665agnh 1183 4 , , , cord-023134-y665agnh 1183 5 a a DT cord-023134-y665agnh 1183 6 rectal rectal JJ cord-023134-y665agnh 1183 7 swab swab NN cord-023134-y665agnh 1183 8 was be VBD cord-023134-y665agnh 1183 9 performed perform VBN cord-023134-y665agnh 1183 10 and and CC cord-023134-y665agnh 1183 11 the the DT cord-023134-y665agnh 1183 12 fecal fecal JJ cord-023134-y665agnh 1183 13 consistency consistency NN cord-023134-y665agnh 1183 14 was be VBD cord-023134-y665agnh 1183 15 evaluated evaluate VBN cord-023134-y665agnh 1183 16 using use VBG cord-023134-y665agnh 1183 17 a a DT cord-023134-y665agnh 1183 18 15-point 15-point JJ cord-023134-y665agnh 1183 19 numerical numerical JJ cord-023134-y665agnh 1183 20 scale scale NN cord-023134-y665agnh 1183 21 ( ( -LRB- cord-023134-y665agnh 1183 22 1 1 CD cord-023134-y665agnh 1183 23 = = SYM cord-023134-y665agnh 1183 24 liquid liquid JJ cord-023134-y665agnh 1183 25 feces fece NNS cord-023134-y665agnh 1183 26 , , , cord-023134-y665agnh 1183 27 15 15 CD cord-023134-y665agnh 1183 28 = = SYM cord-023134-y665agnh 1183 29 hard hard JJ cord-023134-y665agnh 1183 30 feces fece NNS cord-023134-y665agnh 1183 31 ) ) -RRB- cord-023134-y665agnh 1183 32 [ [ -LRB- cord-023134-y665agnh 1183 33 2 2 CD cord-023134-y665agnh 1183 34 ] ] -RRB- cord-023134-y665agnh 1183 35 . . . cord-023134-y665agnh 1184 1 Detection detection NN cord-023134-y665agnh 1184 2 of of IN cord-023134-y665agnh 1184 3 Trichomonads Trichomonads NNP cord-023134-y665agnh 1184 4 was be VBD cord-023134-y665agnh 1184 5 performed perform VBN cord-023134-y665agnh 1184 6 by by IN cord-023134-y665agnh 1184 7 using use VBG cord-023134-y665agnh 1184 8 a a DT cord-023134-y665agnh 1184 9 commercially commercially RB cord-023134-y665agnh 1184 10 available available JJ cord-023134-y665agnh 1184 11 system system NN cord-023134-y665agnh 1184 12 " " '' cord-023134-y665agnh 1184 13 In in IN cord-023134-y665agnh 1184 14 PouchTM pouchtm JJ cord-023134-y665agnh 1184 15 TF TF NNP cord-023134-y665agnh 1184 16 test"(BioMed test"(BioMed NNP cord-023134-y665agnh 1184 17 Diagnostics Diagnostics NNPS cord-023134-y665agnh 1184 18 , , , cord-023134-y665agnh 1184 19 Oregon Oregon NNP cord-023134-y665agnh 1184 20 USA USA NNP cord-023134-y665agnh 1184 21 ) ) -RRB- cord-023134-y665agnh 1184 22 . . . cord-023134-y665agnh 1185 1 Evaluation evaluation NN cord-023134-y665agnh 1185 2 of of IN cord-023134-y665agnh 1185 3 this this DT cord-023134-y665agnh 1185 4 media media NN cord-023134-y665agnh 1185 5 was be VBD cord-023134-y665agnh 1185 6 done do VBN cord-023134-y665agnh 1185 7 as as RB cord-023134-y665agnh 1185 8 already already RB cord-023134-y665agnh 1185 9 described describe VBN cord-023134-y665agnh 1185 10 [ [ -LRB- cord-023134-y665agnh 1185 11 3 3 CD cord-023134-y665agnh 1185 12 ] ] -RRB- cord-023134-y665agnh 1185 13 . . . cord-023134-y665agnh 1186 1 Observation observation NN cord-023134-y665agnh 1186 2 of of IN cord-023134-y665agnh 1186 3 motile motile JJ cord-023134-y665agnh 1186 4 Trichomonads Trichomonads NNP cord-023134-y665agnh 1186 5 organisms organism NNS cord-023134-y665agnh 1186 6 in in IN cord-023134-y665agnh 1186 7 the the DT cord-023134-y665agnh 1186 8 system system NN cord-023134-y665agnh 1186 9 culture culture NN cord-023134-y665agnh 1186 10 was be VBD cord-023134-y665agnh 1186 11 considered consider VBN cord-023134-y665agnh 1186 12 as as IN cord-023134-y665agnh 1186 13 a a DT cord-023134-y665agnh 1186 14 positive positive JJ cord-023134-y665agnh 1186 15 result result NN cord-023134-y665agnh 1186 16 . . . cord-023134-y665agnh 1187 1 Nine nine CD cord-023134-y665agnh 1187 2 positive positive JJ cord-023134-y665agnh 1187 3 culture culture NN cord-023134-y665agnh 1187 4 systems system NNS cord-023134-y665agnh 1187 5 , , , cord-023134-y665agnh 1187 6 from from IN cord-023134-y665agnh 1187 7 one one CD cord-023134-y665agnh 1187 8 kennel kennel NN cord-023134-y665agnh 1187 9 , , , cord-023134-y665agnh 1187 10 were be VBD cord-023134-y665agnh 1187 11 frozen frozen JJ cord-023134-y665agnh 1187 12 and and CC cord-023134-y665agnh 1187 13 single single JJ cord-023134-y665agnh 1187 14 - - HYPH cord-023134-y665agnh 1187 15 tube tube NN cord-023134-y665agnh 1188 1 nested nest VBN cord-023134-y665agnh 1188 2 PCR PCR NNP cord-023134-y665agnh 1188 3 assays assay NNS cord-023134-y665agnh 1188 4 were be VBD cord-023134-y665agnh 1188 5 performed perform VBN cord-023134-y665agnh 1188 6 on on IN cord-023134-y665agnh 1188 7 them -PRON- PRP cord-023134-y665agnh 1188 8 in in IN cord-023134-y665agnh 1188 9 order order NN cord-023134-y665agnh 1188 10 to to TO cord-023134-y665agnh 1188 11 sequence sequence VB cord-023134-y665agnh 1188 12 and and CC cord-023134-y665agnh 1188 13 identify identify VB cord-023134-y665agnh 1188 14 the the DT cord-023134-y665agnh 1188 15 Trichomonads.29.7 trichomonads.29.7 NN cord-023134-y665agnh 1188 16 % % NN cord-023134-y665agnh 1188 17 ( ( -LRB- cord-023134-y665agnh 1188 18 81/273 81/273 CD cord-023134-y665agnh 1188 19 ) ) -RRB- cord-023134-y665agnh 1188 20 of of IN cord-023134-y665agnh 1188 21 the the DT cord-023134-y665agnh 1188 22 cultures culture NNS cord-023134-y665agnh 1188 23 were be VBD cord-023134-y665agnh 1188 24 positive positive JJ cord-023134-y665agnh 1188 25 . . . cord-023134-y665agnh 1189 1 32.6 32.6 CD cord-023134-y665agnh 1189 2 % % NN cord-023134-y665agnh 1189 3 of of IN cord-023134-y665agnh 1189 4 the the DT cord-023134-y665agnh 1189 5 puppies puppy NNS cord-023134-y665agnh 1189 6 ( ( -LRB- cord-023134-y665agnh 1189 7 89/273 89/273 CD cord-023134-y665agnh 1189 8 ) ) -RRB- cord-023134-y665agnh 1189 9 had have VBD cord-023134-y665agnh 1189 10 gastrointestinal gastrointestinal JJ cord-023134-y665agnh 1189 11 troubles trouble NNS cord-023134-y665agnh 1189 12 . . . cord-023134-y665agnh 1190 1 Puppies puppy NNS cord-023134-y665agnh 1190 2 infected infect VBN cord-023134-y665agnh 1190 3 by by IN cord-023134-y665agnh 1190 4 Trichomonads Trichomonads NNP cord-023134-y665agnh 1190 5 had have VBD cord-023134-y665agnh 1190 6 significantly significantly RB cord-023134-y665agnh 1190 7 more more JJR cord-023134-y665agnh 1190 8 digestive digestive JJ cord-023134-y665agnh 1190 9 problems problem NNS cord-023134-y665agnh 1190 10 than than IN cord-023134-y665agnh 1190 11 puppies puppy NNS cord-023134-y665agnh 1190 12 not not RB cord-023134-y665agnh 1190 13 infected infect VBN cord-023134-y665agnh 1190 14 ( ( -LRB- cord-023134-y665agnh 1190 15 49.4 49.4 CD cord-023134-y665agnh 1190 16 % % NN cord-023134-y665agnh 1190 17 vs vs IN cord-023134-y665agnh 1190 18 25.5 25.5 CD cord-023134-y665agnh 1190 19 % % NN cord-023134-y665agnh 1190 20 ; ; : cord-023134-y665agnh 1190 21 p p NN cord-023134-y665agnh 1190 22 < < XX cord-023134-y665agnh 1190 23 0.05 0.05 CD cord-023134-y665agnh 1190 24 ) ) -RRB- cord-023134-y665agnh 1190 25 . . . cord-023134-y665agnh 1191 1 PH PH NNP cord-023134-y665agnh 1191 2 was be VBD cord-023134-y665agnh 1191 3 systematically systematically RB cord-023134-y665agnh 1191 4 isolated isolate VBN cord-023134-y665agnh 1191 5 in in IN cord-023134-y665agnh 1191 6 the the DT cord-023134-y665agnh 1191 7 9 9 CD cord-023134-y665agnh 1191 8 positives positive NNS cord-023134-y665agnh 1191 9 cultures culture NNS cord-023134-y665agnh 1191 10 . . . cord-023134-y665agnh 1192 1 PH PH NNP cord-023134-y665agnh 1192 2 was be VBD cord-023134-y665agnh 1192 3 the the DT cord-023134-y665agnh 1192 4 only only JJ cord-023134-y665agnh 1192 5 Trichomonads Trichomonads NNP cord-023134-y665agnh 1192 6 isolated isolate VBN cord-023134-y665agnh 1192 7 in in IN cord-023134-y665agnh 1192 8 the the DT cord-023134-y665agnh 1192 9 nine nine CD cord-023134-y665agnh 1192 10 culture culture NN cord-023134-y665agnh 1192 11 system system NN cord-023134-y665agnh 1192 12 tested test VBN cord-023134-y665agnh 1192 13 by by IN cord-023134-y665agnh 1192 14 single single JJ cord-023134-y665agnh 1192 15 - - HYPH cord-023134-y665agnh 1192 16 tube tube NN cord-023134-y665agnh 1192 17 nested nest VBN cord-023134-y665agnh 1192 18 PCR PCR NNP cord-023134-y665agnh 1192 19 assay assay NN cord-023134-y665agnh 1192 20 . . . cord-023134-y665agnh 1193 1 These these DT cord-023134-y665agnh 1193 2 results result NNS cord-023134-y665agnh 1193 3 show show VBP cord-023134-y665agnh 1193 4 the the DT cord-023134-y665agnh 1193 5 poor poor JJ cord-023134-y665agnh 1193 6 specificity specificity NN cord-023134-y665agnh 1193 7 of of IN cord-023134-y665agnh 1193 8 the the DT cord-023134-y665agnh 1193 9 medium medium NN cord-023134-y665agnh 1193 10 to to TO cord-023134-y665agnh 1193 11 distinguish distinguish VB cord-023134-y665agnh 1193 12 TF TF NNP cord-023134-y665agnh 1193 13 from from IN cord-023134-y665agnh 1193 14 PH PH NNP cord-023134-y665agnh 1193 15 . . . cord-023134-y665agnh 1194 1 This this DT cord-023134-y665agnh 1194 2 observation observation NN cord-023134-y665agnh 1194 3 underlines underline VBZ cord-023134-y665agnh 1194 4 the the DT cord-023134-y665agnh 1194 5 necessity necessity NN cord-023134-y665agnh 1194 6 to to TO cord-023134-y665agnh 1194 7 use use VB cord-023134-y665agnh 1194 8 PCR PCR NNP cord-023134-y665agnh 1194 9 for for IN cord-023134-y665agnh 1194 10 precise precise JJ cord-023134-y665agnh 1194 11 identification identification NN cord-023134-y665agnh 1194 12 of of IN cord-023134-y665agnh 1194 13 type type NN cord-023134-y665agnh 1194 14 of of IN cord-023134-y665agnh 1194 15 Trichomonads Trichomonads NNP cord-023134-y665agnh 1194 16 . . . cord-023134-y665agnh 1195 1 Trichomonads trichomonad NNS cord-023134-y665agnh 1195 2 are be VBP cord-023134-y665agnh 1195 3 significantly significantly RB cord-023134-y665agnh 1195 4 associated associate VBN cord-023134-y665agnh 1195 5 to to IN cord-023134-y665agnh 1195 6 the the DT cord-023134-y665agnh 1195 7 presence presence NN cord-023134-y665agnh 1195 8 of of IN cord-023134-y665agnh 1195 9 digestive digestive JJ cord-023134-y665agnh 1195 10 disorders disorder NNS cord-023134-y665agnh 1195 11 in in IN cord-023134-y665agnh 1195 12 puppies puppy NNS cord-023134-y665agnh 1195 13 . . . cord-023134-y665agnh 1196 1 Some some DT cord-023134-y665agnh 1196 2 etiological etiological JJ cord-023134-y665agnh 1196 3 studies study NNS cord-023134-y665agnh 1196 4 on on IN cord-023134-y665agnh 1196 5 the the DT cord-023134-y665agnh 1196 6 subject subject NN cord-023134-y665agnh 1196 7 ( ( -LRB- cord-023134-y665agnh 1196 8 by by IN cord-023134-y665agnh 1196 9 considering consider VBG cord-023134-y665agnh 1196 10 the the DT cord-023134-y665agnh 1196 11 co co NN cord-023134-y665agnh 1196 12 - - NN cord-023134-y665agnh 1196 13 infection infection NN cord-023134-y665agnh 1196 14 with with IN cord-023134-y665agnh 1196 15 Fly fly NN cord-023134-y665agnh 1196 16 snapping snap VBG cord-023134-y665agnh 1196 17 , , , cord-023134-y665agnh 1196 18 fly fly VB cord-023134-y665agnh 1196 19 - - HYPH cord-023134-y665agnh 1196 20 biting biting NN cord-023134-y665agnh 1196 21 or or CC cord-023134-y665agnh 1196 22 jaw jaw NN cord-023134-y665agnh 1196 23 snapping snap VBG cord-023134-y665agnh 1196 24 are be VBP cord-023134-y665agnh 1196 25 names name NNS cord-023134-y665agnh 1196 26 given give VBN cord-023134-y665agnh 1196 27 to to IN cord-023134-y665agnh 1196 28 a a DT cord-023134-y665agnh 1196 29 syndrome syndrome NN cord-023134-y665agnh 1196 30 in in IN cord-023134-y665agnh 1196 31 which which WDT cord-023134-y665agnh 1196 32 dogs dog NNS cord-023134-y665agnh 1196 33 appear appear VBP cord-023134-y665agnh 1196 34 to to TO cord-023134-y665agnh 1196 35 be be VB cord-023134-y665agnh 1196 36 watching watch VBG cord-023134-y665agnh 1196 37 something something NN cord-023134-y665agnh 1196 38 then then RB cord-023134-y665agnh 1196 39 suddenly suddenly RB cord-023134-y665agnh 1196 40 leaping leap VBG cord-023134-y665agnh 1196 41 and and CC cord-023134-y665agnh 1196 42 snapping snap VBG cord-023134-y665agnh 1196 43 at at IN cord-023134-y665agnh 1196 44 it -PRON- PRP cord-023134-y665agnh 1196 45 . . . cord-023134-y665agnh 1197 1 Fly fly VB cord-023134-y665agnh 1197 2 - - HYPH cord-023134-y665agnh 1197 3 biting bite VBG cord-023134-y665agnh 1197 4 dogs dog NNS cord-023134-y665agnh 1197 5 are be VBP cord-023134-y665agnh 1197 6 generally generally RB cord-023134-y665agnh 1197 7 referred refer VBN cord-023134-y665agnh 1197 8 to to IN cord-023134-y665agnh 1197 9 neurologists neurologist NNS cord-023134-y665agnh 1197 10 or or CC cord-023134-y665agnh 1197 11 behaviourists behaviourist NNS cord-023134-y665agnh 1197 12 because because IN cord-023134-y665agnh 1197 13 the the DT cord-023134-y665agnh 1197 14 abnormalities abnormality NNS cord-023134-y665agnh 1197 15 are be VBP cord-023134-y665agnh 1197 16 often often RB cord-023134-y665agnh 1197 17 interpreted interpret VBN cord-023134-y665agnh 1197 18 as as IN cord-023134-y665agnh 1197 19 focal focal JJ cord-023134-y665agnh 1197 20 seizures seizure NNS cord-023134-y665agnh 1197 21 or or CC cord-023134-y665agnh 1197 22 as as IN cord-023134-y665agnh 1197 23 obsessive obsessive JJ cord-023134-y665agnh 1197 24 compulsive compulsive JJ cord-023134-y665agnh 1197 25 disorder disorder NN cord-023134-y665agnh 1197 26 ( ( -LRB- cord-023134-y665agnh 1197 27 OCD OCD NNP cord-023134-y665agnh 1197 28 ) ) -RRB- cord-023134-y665agnh 1197 29 . . . cord-023134-y665agnh 1198 1 There there EX cord-023134-y665agnh 1198 2 is be VBZ cord-023134-y665agnh 1198 3 one one CD cord-023134-y665agnh 1198 4 published publish VBN cord-023134-y665agnh 1198 5 case case NN cord-023134-y665agnh 1198 6 report report NN cord-023134-y665agnh 1198 7 of of IN cord-023134-y665agnh 1198 8 fly fly NN cord-023134-y665agnh 1198 9 biting bite VBG cord-023134-y665agnh 1198 10 presumably presumably RB cord-023134-y665agnh 1198 11 caused cause VBN cord-023134-y665agnh 1198 12 by by IN cord-023134-y665agnh 1198 13 dietary dietary JJ cord-023134-y665agnh 1198 14 intolerance intolerance NN cord-023134-y665agnh 1198 15 in in IN cord-023134-y665agnh 1198 16 a a DT cord-023134-y665agnh 1198 17 Cavalier Cavalier NNP cord-023134-y665agnh 1198 18 King King NNP cord-023134-y665agnh 1198 19 Charles Charles NNP cord-023134-y665agnh 1198 20 Spaniel Spaniel NNP cord-023134-y665agnh 1198 21 . . . cord-023134-y665agnh 1199 1 The the DT cord-023134-y665agnh 1199 2 aims aim NNS cord-023134-y665agnh 1199 3 of of IN cord-023134-y665agnh 1199 4 this this DT cord-023134-y665agnh 1199 5 case case NN cord-023134-y665agnh 1199 6 series series NN cord-023134-y665agnh 1199 7 were be VBD cord-023134-y665agnh 1199 8 1 1 CD cord-023134-y665agnh 1199 9 ) ) -RRB- cord-023134-y665agnh 1199 10 to to TO cord-023134-y665agnh 1199 11 characterize characterize VB cord-023134-y665agnh 1199 12 fly fly NN cord-023134-y665agnh 1199 13 biting biting NN cord-023134-y665agnh 1199 14 , , , cord-023134-y665agnh 1199 15 2 2 CD cord-023134-y665agnh 1199 16 ) ) -RRB- cord-023134-y665agnh 1199 17 perform perform VB cord-023134-y665agnh 1199 18 a a DT cord-023134-y665agnh 1199 19 complete complete JJ cord-023134-y665agnh 1199 20 medical medical JJ cord-023134-y665agnh 1199 21 evaluation evaluation NN cord-023134-y665agnh 1199 22 of of IN cord-023134-y665agnh 1199 23 dogs dog NNS cord-023134-y665agnh 1199 24 presented present VBN cord-023134-y665agnh 1199 25 with with IN cord-023134-y665agnh 1199 26 fly fly NN cord-023134-y665agnh 1199 27 biting biting NN cord-023134-y665agnh 1199 28 , , , cord-023134-y665agnh 1199 29 and and CC cord-023134-y665agnh 1199 30 3 3 LS cord-023134-y665agnh 1199 31 ) ) -RRB- cord-023134-y665agnh 1199 32 evaluate evaluate VB cord-023134-y665agnh 1199 33 the the DT cord-023134-y665agnh 1199 34 outcome outcome NN cord-023134-y665agnh 1199 35 of of IN cord-023134-y665agnh 1199 36 this this DT cord-023134-y665agnh 1199 37 behaviour behaviour NN cord-023134-y665agnh 1199 38 following follow VBG cord-023134-y665agnh 1199 39 appropriate appropriate JJ cord-023134-y665agnh 1199 40 treatment treatment NN cord-023134-y665agnh 1199 41 of of IN cord-023134-y665agnh 1199 42 the the DT cord-023134-y665agnh 1199 43 underlying underlying JJ cord-023134-y665agnh 1199 44 medical medical JJ cord-023134-y665agnh 1199 45 condition condition NN cord-023134-y665agnh 1199 46 . . . cord-023134-y665agnh 1200 1 Seven seven CD cord-023134-y665agnh 1200 2 dogs dog NNS cord-023134-y665agnh 1200 3 presented present VBN cord-023134-y665agnh 1200 4 for for IN cord-023134-y665agnh 1200 5 fly fly NN cord-023134-y665agnh 1200 6 - - HYPH cord-023134-y665agnh 1200 7 biting bite VBG cord-023134-y665agnh 1200 8 behaviour behaviour NN cord-023134-y665agnh 1200 9 ( ( -LRB- cord-023134-y665agnh 1200 10 FB fb NN cord-023134-y665agnh 1200 11 ) ) -RRB- cord-023134-y665agnh 1200 12 were be VBD cord-023134-y665agnh 1200 13 assessed assess VBN cord-023134-y665agnh 1200 14 . . . cord-023134-y665agnh 1201 1 All all DT cord-023134-y665agnh 1201 2 dogs dog NNS cord-023134-y665agnh 1201 3 underwent undergo VBD cord-023134-y665agnh 1201 4 a a DT cord-023134-y665agnh 1201 5 complete complete JJ cord-023134-y665agnh 1201 6 medical medical JJ cord-023134-y665agnh 1201 7 and and CC cord-023134-y665agnh 1201 8 behavioural behavioural JJ cord-023134-y665agnh 1201 9 history history NN cord-023134-y665agnh 1201 10 as as RB cord-023134-y665agnh 1201 11 well well RB cord-023134-y665agnh 1201 12 as as IN cord-023134-y665agnh 1201 13 physical physical JJ cord-023134-y665agnh 1201 14 and and CC cord-023134-y665agnh 1201 15 neurological neurological JJ cord-023134-y665agnh 1201 16 examinations examination NNS cord-023134-y665agnh 1201 17 . . . cord-023134-y665agnh 1202 1 Further further JJ cord-023134-y665agnh 1202 2 investigation investigation NN cord-023134-y665agnh 1202 3 was be VBD cord-023134-y665agnh 1202 4 performed perform VBN cord-023134-y665agnh 1202 5 if if IN cord-023134-y665agnh 1202 6 an an DT cord-023134-y665agnh 1202 7 abnormality abnormality NN cord-023134-y665agnh 1202 8 was be VBD cord-023134-y665agnh 1202 9 found find VBN cord-023134-y665agnh 1202 10 on on IN cord-023134-y665agnh 1202 11 examination examination NN cord-023134-y665agnh 1202 12 or or CC cord-023134-y665agnh 1202 13 if if IN cord-023134-y665agnh 1202 14 the the DT cord-023134-y665agnh 1202 15 history history NN cord-023134-y665agnh 1202 16 was be VBD cord-023134-y665agnh 1202 17 suggestive suggestive JJ cord-023134-y665agnh 1202 18 of of IN cord-023134-y665agnh 1202 19 an an DT cord-023134-y665agnh 1202 20 underlying underlying JJ cord-023134-y665agnh 1202 21 problem problem NN cord-023134-y665agnh 1202 22 . . . cord-023134-y665agnh 1203 1 Based base VBN cord-023134-y665agnh 1203 2 on on IN cord-023134-y665agnh 1203 3 clinical clinical JJ cord-023134-y665agnh 1203 4 presentation presentation NN cord-023134-y665agnh 1203 5 , , , cord-023134-y665agnh 1203 6 physical physical JJ cord-023134-y665agnh 1203 7 examination examination NN cord-023134-y665agnh 1203 8 , , , cord-023134-y665agnh 1203 9 neurologic neurologic JJ cord-023134-y665agnh 1203 10 examination examination NN cord-023134-y665agnh 1203 11 , , , cord-023134-y665agnh 1203 12 and and CC cord-023134-y665agnh 1203 13 laboratory laboratory NN cord-023134-y665agnh 1203 14 test test NN cord-023134-y665agnh 1203 15 results result NNS cord-023134-y665agnh 1203 16 , , , cord-023134-y665agnh 1203 17 a a DT cord-023134-y665agnh 1203 18 diagnosis diagnosis NN cord-023134-y665agnh 1203 19 was be VBD cord-023134-y665agnh 1203 20 made make VBN cord-023134-y665agnh 1203 21 and and CC cord-023134-y665agnh 1203 22 a a DT cord-023134-y665agnh 1203 23 specific specific JJ cord-023134-y665agnh 1203 24 treatment treatment NN cord-023134-y665agnh 1203 25 recommended recommend VBN cord-023134-y665agnh 1203 26 . . . cord-023134-y665agnh 1204 1 Response response NN cord-023134-y665agnh 1204 2 to to IN cord-023134-y665agnh 1204 3 treatment treatment NN cord-023134-y665agnh 1204 4 was be VBD cord-023134-y665agnh 1204 5 monitored monitor VBN cord-023134-y665agnh 1204 6 and and CC cord-023134-y665agnh 1204 7 evaluated evaluate VBN cord-023134-y665agnh 1204 8 following follow VBG cord-023134-y665agnh 1204 9 phone phone NN cord-023134-y665agnh 1204 10 conversations conversation NNS cord-023134-y665agnh 1204 11 with with IN cord-023134-y665agnh 1204 12 owners owner NNS cord-023134-y665agnh 1204 13 at at IN cord-023134-y665agnh 1204 14 day day NN cord-023134-y665agnh 1204 15 30 30 CD cord-023134-y665agnh 1204 16 , , , cord-023134-y665agnh 1204 17 60 60 CD cord-023134-y665agnh 1204 18 and and CC cord-023134-y665agnh 1204 19 90 90 CD cord-023134-y665agnh 1204 20 from from IN cord-023134-y665agnh 1204 21 onset onset NN cord-023134-y665agnh 1204 22 of of IN cord-023134-y665agnh 1204 23 treatment treatment NN cord-023134-y665agnh 1204 24 . . . cord-023134-y665agnh 1205 1 Many many JJ cord-023134-y665agnh 1205 2 gastrointestinal gastrointestinal JJ cord-023134-y665agnh 1205 3 disorders disorder NNS cord-023134-y665agnh 1205 4 were be VBD cord-023134-y665agnh 1205 5 found find VBN cord-023134-y665agnh 1205 6 in in IN cord-023134-y665agnh 1205 7 FB fb NN cord-023134-y665agnh 1205 8 dogs dog NNS cord-023134-y665agnh 1205 9 which which WDT cord-023134-y665agnh 1205 10 included include VBD cord-023134-y665agnh 1205 11 eosinophilic eosinophilic JJ cord-023134-y665agnh 1205 12 and and CC cord-023134-y665agnh 1205 13 lymphoplasmacytic lymphoplasmacytic JJ cord-023134-y665agnh 1205 14 infiltration infiltration NN cord-023134-y665agnh 1205 15 of of IN cord-023134-y665agnh 1205 16 the the DT cord-023134-y665agnh 1205 17 stomach stomach NN cord-023134-y665agnh 1205 18 and and CC cord-023134-y665agnh 1205 19 small small JJ cord-023134-y665agnh 1205 20 bowel bowel NN cord-023134-y665agnh 1205 21 , , , cord-023134-y665agnh 1205 22 delayed delay VBN cord-023134-y665agnh 1205 23 gastric gastric JJ cord-023134-y665agnh 1205 24 emptying emptying NN cord-023134-y665agnh 1205 25 and and CC cord-023134-y665agnh 1205 26 gastroeosophageal gastroeosophageal JJ cord-023134-y665agnh 1205 27 reflux reflux NN cord-023134-y665agnh 1205 28 . . . cord-023134-y665agnh 1206 1 Complete complete JJ cord-023134-y665agnh 1206 2 resolution resolution NN cord-023134-y665agnh 1206 3 of of IN cord-023134-y665agnh 1206 4 the the DT cord-023134-y665agnh 1206 5 FB fb NN cord-023134-y665agnh 1206 6 was be VBD cord-023134-y665agnh 1206 7 observed observe VBN cord-023134-y665agnh 1206 8 in in IN cord-023134-y665agnh 1206 9 5/6 5/6 CD cord-023134-y665agnh 1206 10 dogs dog NNS cord-023134-y665agnh 1206 11 diagnosed diagnose VBN cord-023134-y665agnh 1206 12 and and CC cord-023134-y665agnh 1206 13 specifically specifically RB cord-023134-y665agnh 1206 14 treated treat VBN cord-023134-y665agnh 1206 15 for for IN cord-023134-y665agnh 1206 16 the the DT cord-023134-y665agnh 1206 17 underlying underlie VBG cord-023134-y665agnh 1206 18 gastrointestinal gastrointestinal JJ cord-023134-y665agnh 1206 19 ( ( -LRB- cord-023134-y665agnh 1206 20 GI GI NNP cord-023134-y665agnh 1206 21 ) ) -RRB- cord-023134-y665agnh 1206 22 disease disease NN cord-023134-y665agnh 1206 23 . . . cord-023134-y665agnh 1207 1 One one CD cord-023134-y665agnh 1207 2 dog dog NN cord-023134-y665agnh 1207 3 was be VBD cord-023134-y665agnh 1207 4 diagnosed diagnose VBN cord-023134-y665agnh 1207 5 with with IN cord-023134-y665agnh 1207 6 Chiari Chiari NNP cord-023134-y665agnh 1207 7 malformation malformation NN cord-023134-y665agnh 1207 8 and and CC cord-023134-y665agnh 1207 9 responded respond VBD cord-023134-y665agnh 1207 10 temporarily temporarily RB cord-023134-y665agnh 1207 11 to to IN cord-023134-y665agnh 1207 12 pain pain VB cord-023134-y665agnh 1207 13 management management NN cord-023134-y665agnh 1207 14 . . . cord-023134-y665agnh 1208 1 In in IN cord-023134-y665agnh 1208 2 conclusion conclusion NN cord-023134-y665agnh 1208 3 , , , cord-023134-y665agnh 1208 4 this this DT cord-023134-y665agnh 1208 5 prospective prospective JJ cord-023134-y665agnh 1208 6 case case NN cord-023134-y665agnh 1208 7 series series NN cord-023134-y665agnh 1208 8 indicates indicate VBZ cord-023134-y665agnh 1208 9 that that IN cord-023134-y665agnh 1208 10 fly fly VB cord-023134-y665agnh 1208 11 biting bite VBG cord-023134-y665agnh 1208 12 behaviour behaviour NN cord-023134-y665agnh 1208 13 may may MD cord-023134-y665agnh 1208 14 be be VB cord-023134-y665agnh 1208 15 caused cause VBN cord-023134-y665agnh 1208 16 by by IN cord-023134-y665agnh 1208 17 an an DT cord-023134-y665agnh 1208 18 underlying underlying JJ cord-023134-y665agnh 1208 19 medical medical JJ cord-023134-y665agnh 1208 20 disorder disorder NN cord-023134-y665agnh 1208 21 , , , cord-023134-y665agnh 1208 22 GI GI NNP cord-023134-y665agnh 1208 23 disease disease NN cord-023134-y665agnh 1208 24 being be VBG cord-023134-y665agnh 1208 25 the the DT cord-023134-y665agnh 1208 26 most most RBS cord-023134-y665agnh 1208 27 common common JJ cord-023134-y665agnh 1208 28 . . . cord-023134-y665agnh 1209 1 Resolution resolution NN cord-023134-y665agnh 1209 2 of of IN cord-023134-y665agnh 1209 3 this this DT cord-023134-y665agnh 1209 4 behaviour behaviour NN cord-023134-y665agnh 1209 5 is be VBZ cord-023134-y665agnh 1209 6 possible possible JJ cord-023134-y665agnh 1209 7 following follow VBG cord-023134-y665agnh 1209 8 specific specific JJ cord-023134-y665agnh 1209 9 treatment treatment NN cord-023134-y665agnh 1209 10 of of IN cord-023134-y665agnh 1209 11 the the DT cord-023134-y665agnh 1209 12 underlying underlying JJ cord-023134-y665agnh 1209 13 medical medical JJ cord-023134-y665agnh 1209 14 condition condition NN cord-023134-y665agnh 1209 15 . . . cord-023134-y665agnh 1210 1 Although although IN cord-023134-y665agnh 1210 2 several several JJ cord-023134-y665agnh 1210 3 diagnostic diagnostic JJ cord-023134-y665agnh 1210 4 tests test NNS cord-023134-y665agnh 1210 5 have have VBP cord-023134-y665agnh 1210 6 been be VBN cord-023134-y665agnh 1210 7 developed develop VBN cord-023134-y665agnh 1210 8 to to TO cord-023134-y665agnh 1210 9 diagnose diagnose VB cord-023134-y665agnh 1210 10 FIP FIP NNP cord-023134-y665agnh 1210 11 , , , cord-023134-y665agnh 1210 12 there there EX cord-023134-y665agnh 1210 13 are be VBP cord-023134-y665agnh 1210 14 still still RB cord-023134-y665agnh 1210 15 difficulties difficulty NNS cord-023134-y665agnh 1210 16 to to TO cord-023134-y665agnh 1210 17 differentiate differentiate VB cord-023134-y665agnh 1210 18 between between IN cord-023134-y665agnh 1210 19 FIP fip NN cord-023134-y665agnh 1210 20 and and CC cord-023134-y665agnh 1210 21 diseases disease NNS cord-023134-y665agnh 1210 22 with with IN cord-023134-y665agnh 1210 23 similar similar JJ cord-023134-y665agnh 1210 24 clinical clinical JJ cord-023134-y665agnh 1210 25 appearence appearence NN cord-023134-y665agnh 1210 26 in in IN cord-023134-y665agnh 1210 27 vivo vivo NNP cord-023134-y665agnh 1210 28 . . . cord-023134-y665agnh 1211 1 FIP FIP NNP cord-023134-y665agnh 1211 2 is be VBZ cord-023134-y665agnh 1211 3 an an DT cord-023134-y665agnh 1211 4 inflammatory inflammatory JJ cord-023134-y665agnh 1211 5 disease disease NN cord-023134-y665agnh 1211 6 , , , cord-023134-y665agnh 1211 7 therefore therefore RB cord-023134-y665agnh 1211 8 , , , cord-023134-y665agnh 1211 9 as as IN cord-023134-y665agnh 1211 10 in in IN cord-023134-y665agnh 1211 11 other other JJ cord-023134-y665agnh 1211 12 inflammatory inflammatory JJ cord-023134-y665agnh 1211 13 conditions condition NNS cord-023134-y665agnh 1211 14 , , , cord-023134-y665agnh 1211 15 the the DT cord-023134-y665agnh 1211 16 concentrations concentration NNS cord-023134-y665agnh 1211 17 of of IN cord-023134-y665agnh 1211 18 APPs app NNS cord-023134-y665agnh 1211 19 are be VBP cord-023134-y665agnh 1211 20 expected expect VBN cord-023134-y665agnh 1211 21 to to TO cord-023134-y665agnh 1211 22 be be VB cord-023134-y665agnh 1211 23 increased increase VBN cord-023134-y665agnh 1211 24 . . . cord-023134-y665agnh 1212 1 The the DT cord-023134-y665agnh 1212 2 aim aim NN cord-023134-y665agnh 1212 3 of of IN cord-023134-y665agnh 1212 4 this this DT cord-023134-y665agnh 1212 5 study study NN cord-023134-y665agnh 1212 6 was be VBD cord-023134-y665agnh 1212 7 to to TO cord-023134-y665agnh 1212 8 evaluate evaluate VB cord-023134-y665agnh 1212 9 the the DT cord-023134-y665agnh 1212 10 ability ability NN cord-023134-y665agnh 1212 11 of of IN cord-023134-y665agnh 1212 12 the the DT cord-023134-y665agnh 1212 13 APPs app NNS cord-023134-y665agnh 1212 14 to to TO cord-023134-y665agnh 1212 15 distinguish distinguish VB cord-023134-y665agnh 1212 16 FIP fip NN cord-023134-y665agnh 1212 17 from from IN cord-023134-y665agnh 1212 18 other other JJ cord-023134-y665agnh 1212 19 diseases disease NNS cord-023134-y665agnh 1212 20 . . . cord-023134-y665agnh 1213 1 Serum serum NN cord-023134-y665agnh 1213 2 samples sample NNS cord-023134-y665agnh 1213 3 from from IN cord-023134-y665agnh 1213 4 88 88 CD cord-023134-y665agnh 1213 5 cats cat NNS cord-023134-y665agnh 1213 6 presented present VBN cord-023134-y665agnh 1213 7 with with IN cord-023134-y665agnh 1213 8 effusion effusion NN cord-023134-y665agnh 1213 9 were be VBD cord-023134-y665agnh 1213 10 obtained obtain VBN cord-023134-y665agnh 1213 11 for for IN cord-023134-y665agnh 1213 12 measurement measurement NN cord-023134-y665agnh 1213 13 of of IN cord-023134-y665agnh 1213 14 three three CD cord-023134-y665agnh 1213 15 APPs app NNS cord-023134-y665agnh 1213 16 . . . cord-023134-y665agnh 1214 1 The the DT cord-023134-y665agnh 1214 2 diagnostic diagnostic JJ cord-023134-y665agnh 1214 3 work work NN cord-023134-y665agnh 1214 4 - - HYPH cord-023134-y665agnh 1214 5 up up NN cord-023134-y665agnh 1214 6 was be VBD cord-023134-y665agnh 1214 7 performed perform VBN cord-023134-y665agnh 1214 8 with with IN cord-023134-y665agnh 1214 9 respect respect NN cord-023134-y665agnh 1214 10 to to IN cord-023134-y665agnh 1214 11 FIP FIP NNP cord-023134-y665agnh 1214 12 ( ( -LRB- cord-023134-y665agnh 1214 13 JVIM JVIM NNP cord-023134-y665agnh 1214 14 2011 2011 CD cord-023134-y665agnh 1214 15 ; ; : cord-023134-y665agnh 1214 16 25 25 CD cord-023134-y665agnh 1214 17 : : SYM cord-023134-y665agnh 1214 18 1505 1505 CD cord-023134-y665agnh 1214 19 ) ) -RRB- cord-023134-y665agnh 1214 20 and and CC cord-023134-y665agnh 1214 21 further further JJ cord-023134-y665agnh 1214 22 diagnostic diagnostic JJ cord-023134-y665agnh 1214 23 procedures procedure NNS cord-023134-y665agnh 1214 24 were be VBD cord-023134-y665agnh 1214 25 performed perform VBN cord-023134-y665agnh 1214 26 depending depend VBG cord-023134-y665agnh 1214 27 on on IN cord-023134-y665agnh 1214 28 the the DT cord-023134-y665agnh 1214 29 medical medical JJ cord-023134-y665agnh 1214 30 condition condition NN cord-023134-y665agnh 1214 31 . . . cord-023134-y665agnh 1215 1 20 20 CD cord-023134-y665agnh 1215 2 cats cat NNS cord-023134-y665agnh 1215 3 were be VBD cord-023134-y665agnh 1215 4 diagnosed diagnose VBN cord-023134-y665agnh 1215 5 as as IN cord-023134-y665agnh 1215 6 having have VBG cord-023134-y665agnh 1215 7 FIP FIP NNP cord-023134-y665agnh 1215 8 and and CC cord-023134-y665agnh 1215 9 68 68 CD cord-023134-y665agnh 1215 10 cats cat NNS cord-023134-y665agnh 1215 11 had have VBD cord-023134-y665agnh 1215 12 another another DT cord-023134-y665agnh 1215 13 disease disease NN cord-023134-y665agnh 1215 14 ( ( -LRB- cord-023134-y665agnh 1215 15 cardiac cardiac NNP cord-023134-y665agnh 1215 16 22 22 CD cord-023134-y665agnh 1215 17 , , , cord-023134-y665agnh 1215 18 tumor tumor NN cord-023134-y665agnh 1215 19 24 24 CD cord-023134-y665agnh 1215 20 , , , cord-023134-y665agnh 1215 21 other other JJ cord-023134-y665agnh 1215 22 22 22 CD cord-023134-y665agnh 1215 23 ) ) -RRB- cord-023134-y665agnh 1215 24 . . . cord-023134-y665agnh 1216 1 Serum serum NN cord-023134-y665agnh 1216 2 amyloid amyloid NN cord-023134-y665agnh 1216 3 A a DT cord-023134-y665agnh 1216 4 ( ( -LRB- cord-023134-y665agnh 1216 5 SAA SAA NNP cord-023134-y665agnh 1216 6 ) ) -RRB- cord-023134-y665agnh 1216 7 and and CC cord-023134-y665agnh 1216 8 haptoglobin haptoglobin NN cord-023134-y665agnh 1216 9 ( ( -LRB- cord-023134-y665agnh 1216 10 Hp Hp NNP cord-023134-y665agnh 1216 11 ) ) -RRB- cord-023134-y665agnh 1216 12 were be VBD cord-023134-y665agnh 1216 13 measured measure VBN cord-023134-y665agnh 1216 14 by by IN cord-023134-y665agnh 1216 15 automated automated JJ cord-023134-y665agnh 1216 16 analyser analyser NN cord-023134-y665agnh 1216 17 using use VBG cord-023134-y665agnh 1216 18 feline feline JJ cord-023134-y665agnh 1216 19 validated validate VBN cord-023134-y665agnh 1216 20 assays assay NNS cord-023134-y665agnh 1216 21 ( ( -LRB- cord-023134-y665agnh 1216 22 Eiken Eiken NNP cord-023134-y665agnh 1216 23 and and CC cord-023134-y665agnh 1216 24 Tridelta Tridelta NNP cord-023134-y665agnh 1216 25 , , , cord-023134-y665agnh 1216 26 respectively respectively RB cord-023134-y665agnh 1216 27 ) ) -RRB- cord-023134-y665agnh 1216 28 , , , cord-023134-y665agnh 1216 29 alpha-1-acid alpha-1-acid NNP cord-023134-y665agnh 1216 30 glycoprotein glycoprotein NN cord-023134-y665agnh 1216 31 ( ( -LRB- cord-023134-y665agnh 1216 32 AGP AGP NNP cord-023134-y665agnh 1216 33 ) ) -RRB- cord-023134-y665agnh 1216 34 was be VBD cord-023134-y665agnh 1216 35 measured measure VBN cord-023134-y665agnh 1216 36 using use VBG cord-023134-y665agnh 1216 37 a a DT cord-023134-y665agnh 1216 38 manual manual JJ cord-023134-y665agnh 1216 39 method method NN cord-023134-y665agnh 1216 40 based base VBN cord-023134-y665agnh 1216 41 on on IN cord-023134-y665agnh 1216 42 single single JJ cord-023134-y665agnh 1216 43 radial radial JJ cord-023134-y665agnh 1216 44 immunodiffusion immunodiffusion NN cord-023134-y665agnh 1216 45 ( ( -LRB- cord-023134-y665agnh 1217 1 Tridelta).The Tridelta).The NNP cord-023134-y665agnh 1217 2 median median JJ cord-023134-y665agnh 1217 3 concentrations concentration NNS cord-023134-y665agnh 1217 4 of of IN cord-023134-y665agnh 1217 5 SAA SAA NNP cord-023134-y665agnh 1217 6 , , , cord-023134-y665agnh 1217 7 Hp Hp NNP cord-023134-y665agnh 1217 8 and and CC cord-023134-y665agnh 1217 9 AGP AGP NNP cord-023134-y665agnh 1217 10 were be VBD cord-023134-y665agnh 1217 11 significantly significantly RB cord-023134-y665agnh 1217 12 ( ( -LRB- cord-023134-y665agnh 1217 13 p<0.001 p<0.001 JJ cord-023134-y665agnh 1217 14 ) ) -RRB- cord-023134-y665agnh 1217 15 higher high JJR cord-023134-y665agnh 1217 16 in in IN cord-023134-y665agnh 1217 17 cats cat NNS cord-023134-y665agnh 1217 18 with with IN cord-023134-y665agnh 1217 19 FIP fip NN cord-023134-y665agnh 1217 20 compared compare VBN cord-023134-y665agnh 1217 21 to to IN cord-023134-y665agnh 1217 22 cats cat NNS cord-023134-y665agnh 1217 23 without without IN cord-023134-y665agnh 1217 24 FIP FIP NNP cord-023134-y665agnh 1217 25 ( ( -LRB- cord-023134-y665agnh 1217 26 SAA SAA NNP cord-023134-y665agnh 1217 27 : : : cord-023134-y665agnh 1217 28 98.5 98.5 CD cord-023134-y665agnh 1217 29 ; ; . cord-023134-y665agnh 1218 1 range range VBP cord-023134-y665agnh 1218 2 1.3 1.3 CD cord-023134-y665agnh 1218 3 - - SYM cord-023134-y665agnh 1218 4 163.4 163.4 CD cord-023134-y665agnh 1218 5 lg lg NNP cord-023134-y665agnh 1218 6 / / SYM cord-023134-y665agnh 1218 7 ml ml NN cord-023134-y665agnh 1218 8 ; ; : cord-023134-y665agnh 1218 9 7.6 7.6 CD cord-023134-y665agnh 1218 10 ; ; : cord-023134-y665agnh 1218 11 range range VBP cord-023134-y665agnh 1218 12 0.1 0.1 CD cord-023134-y665agnh 1218 13 - - HYPH cord-023134-y665agnh 1218 14 163.8 163.8 CD cord-023134-y665agnh 1218 15 lg lg NNP cord-023134-y665agnh 1218 16 / / SYM cord-023134-y665agnh 1218 17 ml ml NNP cord-023134-y665agnh 1218 18 , , , cord-023134-y665agnh 1218 19 ) ) -RRB- cord-023134-y665agnh 1218 20 , , , cord-023134-y665agnh 1218 21 ( ( -LRB- cord-023134-y665agnh 1218 22 Hp hp NN cord-023134-y665agnh 1218 23 : : : cord-023134-y665agnh 1218 24 2.0 2.0 CD cord-023134-y665agnh 1218 25 ; ; : cord-023134-y665agnh 1218 26 range range VBP cord-023134-y665agnh 1218 27 2.0 2.0 CD cord-023134-y665agnh 1218 28 - - HYPH cord-023134-y665agnh 1218 29 9.0 9.0 CD cord-023134-y665agnh 1218 30 mg mg NNP cord-023134-y665agnh 1218 31 / / SYM cord-023134-y665agnh 1218 32 ml ml NN cord-023134-y665agnh 1218 33 ; ; : cord-023134-y665agnh 1218 34 1.8 1.8 CD cord-023134-y665agnh 1218 35 ; ; : cord-023134-y665agnh 1218 36 range range VBP cord-023134-y665agnh 1218 37 0.0 0.0 CD cord-023134-y665agnh 1218 38 - - SYM cord-023134-y665agnh 1218 39 2.0 2.0 CD cord-023134-y665agnh 1218 40 mg mg NNP cord-023134-y665agnh 1218 41 / / SYM cord-023134-y665agnh 1218 42 ml ml NNP cord-023134-y665agnh 1218 43 , , , cord-023134-y665agnh 1218 44 ) ) -RRB- cord-023134-y665agnh 1218 45 , , , cord-023134-y665agnh 1218 46 ( ( -LRB- cord-023134-y665agnh 1218 47 AGP agp NN cord-023134-y665agnh 1218 48 : : : cord-023134-y665agnh 1218 49 2900 2900 CD cord-023134-y665agnh 1218 50 ; ; : cord-023134-y665agnh 1218 51 range range VBP cord-023134-y665agnh 1218 52 960 960 CD cord-023134-y665agnh 1218 53 - - HYPH cord-023134-y665agnh 1218 54 5040 5040 CD cord-023134-y665agnh 1218 55 lg lg NNP cord-023134-y665agnh 1218 56 / / SYM cord-023134-y665agnh 1218 57 ml ml NN cord-023134-y665agnh 1218 58 ; ; : cord-023134-y665agnh 1218 59 690 690 CD cord-023134-y665agnh 1218 60 , , , cord-023134-y665agnh 1219 1 range range VBP cord-023134-y665agnh 1219 2 120 120 CD cord-023134-y665agnh 1219 3 - - HYPH cord-023134-y665agnh 1219 4 4500 4500 CD cord-023134-y665agnh 1220 1 lg lg NNP cord-023134-y665agnh 1220 2 / / SYM cord-023134-y665agnh 1220 3 ml).All ml).all CD cord-023134-y665agnh 1220 4 major major JJ cord-023134-y665agnh 1220 5 feline feline JJ cord-023134-y665agnh 1220 6 APPs app NNS cord-023134-y665agnh 1220 7 seem seem VBP cord-023134-y665agnh 1220 8 to to TO cord-023134-y665agnh 1220 9 be be VB cord-023134-y665agnh 1220 10 useful useful JJ cord-023134-y665agnh 1220 11 diagnostic diagnostic JJ cord-023134-y665agnh 1220 12 tools tool NNS cord-023134-y665agnh 1220 13 to to TO cord-023134-y665agnh 1220 14 help help VB cord-023134-y665agnh 1220 15 in in IN cord-023134-y665agnh 1220 16 differentiating differentiate VBG cord-023134-y665agnh 1220 17 FIP FIP NNP cord-023134-y665agnh 1220 18 from from IN cord-023134-y665agnh 1220 19 other other JJ cord-023134-y665agnh 1220 20 diseases disease NNS cord-023134-y665agnh 1220 21 . . . cord-023134-y665agnh 1221 1 However however RB cord-023134-y665agnh 1221 2 , , , cord-023134-y665agnh 1221 3 the the DT cord-023134-y665agnh 1221 4 concentration concentration NN cord-023134-y665agnh 1221 5 of of IN cord-023134-y665agnh 1221 6 APPs app NNS cord-023134-y665agnh 1221 7 in in IN cord-023134-y665agnh 1221 8 some some DT cord-023134-y665agnh 1221 9 diseases disease NNS cord-023134-y665agnh 1221 10 ( ( -LRB- cord-023134-y665agnh 1221 11 septic septic JJ cord-023134-y665agnh 1221 12 processes process NNS cord-023134-y665agnh 1221 13 , , , cord-023134-y665agnh 1221 14 disseminated disseminate VBN cord-023134-y665agnh 1221 15 neoplasias neoplasias NNP cord-023134-y665agnh 1221 16 ) ) -RRB- cord-023134-y665agnh 1221 17 was be VBD cord-023134-y665agnh 1221 18 as as RB cord-023134-y665agnh 1221 19 high high JJ cord-023134-y665agnh 1221 20 as as IN cord-023134-y665agnh 1221 21 in in IN cord-023134-y665agnh 1221 22 FIP FIP NNP cord-023134-y665agnh 1221 23 . . . cord-023134-y665agnh 1222 1 Protothecosis protothecosis NN cord-023134-y665agnh 1222 2 is be VBZ cord-023134-y665agnh 1222 3 an an DT cord-023134-y665agnh 1222 4 uncommon uncommon JJ cord-023134-y665agnh 1222 5 disease disease NN cord-023134-y665agnh 1222 6 of of IN cord-023134-y665agnh 1222 7 people people NNS cord-023134-y665agnh 1222 8 and and CC cord-023134-y665agnh 1222 9 animals animal NNS cord-023134-y665agnh 1222 10 caused cause VBN cord-023134-y665agnh 1222 11 by by IN cord-023134-y665agnh 1222 12 Prototheca Prototheca NNP cord-023134-y665agnh 1222 13 spp spp NNS cord-023134-y665agnh 1222 14 . . . cord-023134-y665agnh 1223 1 , , , cord-023134-y665agnh 1223 2 an an DT cord-023134-y665agnh 1223 3 unicellular unicellular JJ cord-023134-y665agnh 1223 4 aerobic aerobic JJ cord-023134-y665agnh 1223 5 algae algae NN cord-023134-y665agnh 1223 6 . . . cord-023134-y665agnh 1224 1 To to IN cord-023134-y665agnh 1224 2 date date NN cord-023134-y665agnh 1224 3 , , , cord-023134-y665agnh 1224 4 about about RB cord-023134-y665agnh 1224 5 30 30 CD cord-023134-y665agnh 1224 6 cases case NNS cord-023134-y665agnh 1224 7 have have VBP cord-023134-y665agnh 1224 8 been be VBN cord-023134-y665agnh 1224 9 described describe VBN cord-023134-y665agnh 1224 10 in in IN cord-023134-y665agnh 1224 11 dogs dog NNS cord-023134-y665agnh 1224 12 in in IN cord-023134-y665agnh 1224 13 North North NNP cord-023134-y665agnh 1224 14 America America NNP cord-023134-y665agnh 1224 15 and and CC cord-023134-y665agnh 1224 16 Australia Australia NNP cord-023134-y665agnh 1224 17 . . . cord-023134-y665agnh 1225 1 In in IN cord-023134-y665agnh 1225 2 Europe Europe NNP cord-023134-y665agnh 1225 3 , , , cord-023134-y665agnh 1225 4 only only RB cord-023134-y665agnh 1225 5 4 4 CD cord-023134-y665agnh 1225 6 cases case NNS cord-023134-y665agnh 1225 7 have have VBP cord-023134-y665agnh 1225 8 been be VBN cord-023134-y665agnh 1225 9 documented document VBN cord-023134-y665agnh 1225 10 in in IN cord-023134-y665agnh 1225 11 the the DT cord-023134-y665agnh 1225 12 last last JJ cord-023134-y665agnh 1225 13 2 2 CD cord-023134-y665agnh 1225 14 decades decade NNS cord-023134-y665agnh 1225 15 ( ( -LRB- cord-023134-y665agnh 1225 16 Poland Poland NNP cord-023134-y665agnh 1225 17 , , , cord-023134-y665agnh 1225 18 Italy Italy NNP cord-023134-y665agnh 1225 19 , , , cord-023134-y665agnh 1225 20 Greece Greece NNP cord-023134-y665agnh 1225 21 and and CC cord-023134-y665agnh 1225 22 Spain Spain NNP cord-023134-y665agnh 1225 23 ) ) -RRB- cord-023134-y665agnh 1225 24 . . . cord-023134-y665agnh 1226 1 Affected affected JJ cord-023134-y665agnh 1226 2 dogs dog NNS cord-023134-y665agnh 1226 3 show show VBP cord-023134-y665agnh 1226 4 signs sign NNS cord-023134-y665agnh 1226 5 referable referable JJ cord-023134-y665agnh 1226 6 to to IN cord-023134-y665agnh 1226 7 the the DT cord-023134-y665agnh 1226 8 gastro gastro JJ cord-023134-y665agnh 1226 9 - - JJ cord-023134-y665agnh 1226 10 intestinal intestinal JJ cord-023134-y665agnh 1226 11 tract tract NN cord-023134-y665agnh 1226 12 , , , cord-023134-y665agnh 1226 13 particularly particularly RB cord-023134-y665agnh 1226 14 the the DT cord-023134-y665agnh 1226 15 colon colon NN cord-023134-y665agnh 1226 16 , , , cord-023134-y665agnh 1226 17 but but CC cord-023134-y665agnh 1226 18 ocular ocular JJ cord-023134-y665agnh 1226 19 and and CC cord-023134-y665agnh 1226 20 neurologic neurologic JJ cord-023134-y665agnh 1226 21 signs sign NNS cord-023134-y665agnh 1226 22 are be VBP cord-023134-y665agnh 1226 23 also also RB cord-023134-y665agnh 1226 24 reported report VBN cord-023134-y665agnh 1226 25 . . . cord-023134-y665agnh 1227 1 The the DT cord-023134-y665agnh 1227 2 disease disease NN cord-023134-y665agnh 1227 3 has have VBZ cord-023134-y665agnh 1227 4 an an DT cord-023134-y665agnh 1227 5 insidious insidious JJ cord-023134-y665agnh 1227 6 onset onset NN cord-023134-y665agnh 1227 7 , , , cord-023134-y665agnh 1227 8 a a DT cord-023134-y665agnh 1227 9 slow slow JJ cord-023134-y665agnh 1227 10 progression progression NN cord-023134-y665agnh 1227 11 and and CC cord-023134-y665agnh 1227 12 fatal fatal JJ cord-023134-y665agnh 1227 13 course course NN cord-023134-y665agnh 1227 14 . . . cord-023134-y665agnh 1228 1 The the DT cord-023134-y665agnh 1228 2 aim aim NN cord-023134-y665agnh 1228 3 of of IN cord-023134-y665agnh 1228 4 the the DT cord-023134-y665agnh 1228 5 present present JJ cord-023134-y665agnh 1228 6 study study NN cord-023134-y665agnh 1228 7 is be VBZ cord-023134-y665agnh 1228 8 to to TO cord-023134-y665agnh 1228 9 describe describe VB cord-023134-y665agnh 1228 10 clinical clinical JJ cord-023134-y665agnh 1228 11 and and CC cord-023134-y665agnh 1228 12 laboratory laboratory NN cord-023134-y665agnh 1228 13 findings finding NNS cord-023134-y665agnh 1228 14 in in IN cord-023134-y665agnh 1228 15 4 4 CD cord-023134-y665agnh 1228 16 cases case NNS cord-023134-y665agnh 1228 17 of of IN cord-023134-y665agnh 1228 18 canine canine JJ cord-023134-y665agnh 1228 19 protothecosis protothecosis NN cord-023134-y665agnh 1228 20 from from IN cord-023134-y665agnh 1228 21 the the DT cord-023134-y665agnh 1228 22 north north NN cord-023134-y665agnh 1228 23 of of IN cord-023134-y665agnh 1228 24 Italy Italy NNP cord-023134-y665agnh 1228 25 , , , cord-023134-y665agnh 1228 26 diagnosed diagnose VBN cord-023134-y665agnh 1228 27 between between IN cord-023134-y665agnh 1228 28 2009 2009 CD cord-023134-y665agnh 1228 29 - - SYM cord-023134-y665agnh 1228 30 2011 2011 CD cord-023134-y665agnh 1228 31 . . . cord-023134-y665agnh 1229 1 Medical medical JJ cord-023134-y665agnh 1229 2 records record NNS cord-023134-y665agnh 1229 3 were be VBD cord-023134-y665agnh 1229 4 retrieved retrieve VBN cord-023134-y665agnh 1229 5 and and CC cord-023134-y665agnh 1229 6 information information NN cord-023134-y665agnh 1229 7 pertaining pertain VBG cord-023134-y665agnh 1229 8 history history NN cord-023134-y665agnh 1229 9 , , , cord-023134-y665agnh 1229 10 clinical clinical JJ cord-023134-y665agnh 1229 11 and and CC cord-023134-y665agnh 1229 12 instrumental instrumental JJ cord-023134-y665agnh 1229 13 data datum NNS cord-023134-y665agnh 1229 14 , , , cord-023134-y665agnh 1229 15 as as RB cord-023134-y665agnh 1229 16 well well RB cord-023134-y665agnh 1229 17 as as IN cord-023134-y665agnh 1229 18 follow follow NN cord-023134-y665agnh 1229 19 - - HYPH cord-023134-y665agnh 1229 20 up up NN cord-023134-y665agnh 1229 21 , , , cord-023134-y665agnh 1229 22 were be VBD cord-023134-y665agnh 1229 23 collected collect VBN cord-023134-y665agnh 1229 24 . . . cord-023134-y665agnh 1230 1 The the DT cord-023134-y665agnh 1230 2 median median JJ cord-023134-y665agnh 1230 3 age age NN cord-023134-y665agnh 1230 4 of of IN cord-023134-y665agnh 1230 5 the the DT cord-023134-y665agnh 1230 6 4 4 CD cord-023134-y665agnh 1230 7 dogs dog NNS cord-023134-y665agnh 1230 8 was be VBD cord-023134-y665agnh 1230 9 8 8 CD cord-023134-y665agnh 1230 10 years year NNS cord-023134-y665agnh 1231 1 ( ( -LRB- cord-023134-y665agnh 1231 2 range range NN cord-023134-y665agnh 1231 3 : : : cord-023134-y665agnh 1231 4 5 5 CD cord-023134-y665agnh 1231 5 - - SYM cord-023134-y665agnh 1231 6 11 11 CD cord-023134-y665agnh 1231 7 ) ) -RRB- cord-023134-y665agnh 1231 8 , , , cord-023134-y665agnh 1231 9 3 3 CD cord-023134-y665agnh 1231 10 of of IN cord-023134-y665agnh 1231 11 them -PRON- PRP cord-023134-y665agnh 1231 12 were be VBD cord-023134-y665agnh 1231 13 female female JJ cord-023134-y665agnh 1231 14 and and CC cord-023134-y665agnh 1231 15 2 2 CD cord-023134-y665agnh 1231 16 were be VBD cord-023134-y665agnh 1231 17 Boxers boxer NNS cord-023134-y665agnh 1231 18 . . . cord-023134-y665agnh 1232 1 Major major JJ cord-023134-y665agnh 1232 2 complaints complaint NNS cord-023134-y665agnh 1232 3 were be VBD cord-023134-y665agnh 1232 4 chronic chronic JJ cord-023134-y665agnh 1232 5 large large JJ cord-023134-y665agnh 1232 6 bowel bowel NN cord-023134-y665agnh 1232 7 diarrhea diarrhea NN cord-023134-y665agnh 1232 8 with with IN cord-023134-y665agnh 1232 9 hematochezia hematochezia NNP cord-023134-y665agnh 1232 10 and and CC cord-023134-y665agnh 1232 11 weight weight NN cord-023134-y665agnh 1232 12 loss loss NN cord-023134-y665agnh 1232 13 observed observe VBN cord-023134-y665agnh 1232 14 since since IN cord-023134-y665agnh 1232 15 a a DT cord-023134-y665agnh 1232 16 median median JJ cord-023134-y665agnh 1232 17 time time NN cord-023134-y665agnh 1232 18 of of IN cord-023134-y665agnh 1232 19 3 3 CD cord-023134-y665agnh 1232 20 months month NNS cord-023134-y665agnh 1233 1 ( ( -LRB- cord-023134-y665agnh 1233 2 range range NN cord-023134-y665agnh 1233 3 : : : cord-023134-y665agnh 1233 4 1 1 CD cord-023134-y665agnh 1233 5 to to IN cord-023134-y665agnh 1233 6 7 7 CD cord-023134-y665agnh 1233 7 ) ) -RRB- cord-023134-y665agnh 1233 8 . . . cord-023134-y665agnh 1234 1 Previous previous JJ cord-023134-y665agnh 1234 2 treatment treatment NN cord-023134-y665agnh 1234 3 with with IN cord-023134-y665agnh 1234 4 gastrointestinal gastrointestinal JJ cord-023134-y665agnh 1234 5 diets diet NNS cord-023134-y665agnh 1234 6 , , , cord-023134-y665agnh 1234 7 antiparasitic antiparasitic JJ cord-023134-y665agnh 1234 8 drugs drug NNS cord-023134-y665agnh 1234 9 and and CC cord-023134-y665agnh 1234 10 antibiotics antibiotic NNS cord-023134-y665agnh 1234 11 yielded yield VBD cord-023134-y665agnh 1234 12 no no DT cord-023134-y665agnh 1234 13 improvement improvement NN cord-023134-y665agnh 1234 14 . . . cord-023134-y665agnh 1235 1 Additionally additionally RB cord-023134-y665agnh 1235 2 , , , cord-023134-y665agnh 1235 3 2 2 CD cord-023134-y665agnh 1235 4 dogs dog NNS cord-023134-y665agnh 1235 5 developed develop VBD cord-023134-y665agnh 1235 6 uveitis uveitis NN cord-023134-y665agnh 1235 7 during during IN cord-023134-y665agnh 1235 8 the the DT cord-023134-y665agnh 1235 9 disease disease NN cord-023134-y665agnh 1235 10 course course NN cord-023134-y665agnh 1235 11 . . . cord-023134-y665agnh 1236 1 In in IN cord-023134-y665agnh 1236 2 all all DT cord-023134-y665agnh 1236 3 dogs dog NNS cord-023134-y665agnh 1236 4 a a DT cord-023134-y665agnh 1236 5 complete complete JJ cord-023134-y665agnh 1236 6 blood blood NN cord-023134-y665agnh 1236 7 count count NN cord-023134-y665agnh 1236 8 , , , cord-023134-y665agnh 1236 9 a a DT cord-023134-y665agnh 1236 10 serum serum NN cord-023134-y665agnh 1236 11 biochemical biochemical JJ cord-023134-y665agnh 1236 12 profile profile NN cord-023134-y665agnh 1236 13 , , , cord-023134-y665agnh 1236 14 including include VBG cord-023134-y665agnh 1236 15 protein protein NN cord-023134-y665agnh 1236 16 electrophoresis electrophoresis NN cord-023134-y665agnh 1236 17 , , , cord-023134-y665agnh 1236 18 and and CC cord-023134-y665agnh 1236 19 abdominal abdominal JJ cord-023134-y665agnh 1236 20 ultrasound ultrasound NN cord-023134-y665agnh 1236 21 were be VBD cord-023134-y665agnh 1236 22 performed perform VBN cord-023134-y665agnh 1236 23 ; ; : cord-023134-y665agnh 1236 24 serum serum NN cord-023134-y665agnh 1236 25 cTLI ctli NN cord-023134-y665agnh 1236 26 , , , cord-023134-y665agnh 1236 27 folate folate NN cord-023134-y665agnh 1236 28 and and CC cord-023134-y665agnh 1236 29 cobalamin cobalamin NN cord-023134-y665agnh 1236 30 were be VBD cord-023134-y665agnh 1236 31 available available JJ cord-023134-y665agnh 1236 32 in in IN cord-023134-y665agnh 1236 33 3 3 CD cord-023134-y665agnh 1236 34 dogs dog NNS cord-023134-y665agnh 1236 35 and and CC cord-023134-y665agnh 1236 36 urinalysis urinalysis NN cord-023134-y665agnh 1236 37 in in IN cord-023134-y665agnh 1236 38 one one CD cord-023134-y665agnh 1236 39 . . . cord-023134-y665agnh 1237 1 The the DT cord-023134-y665agnh 1237 2 results result NNS cord-023134-y665agnh 1237 3 of of IN cord-023134-y665agnh 1237 4 the the DT cord-023134-y665agnh 1237 5 above above JJ cord-023134-y665agnh 1237 6 laboratory laboratory NN cord-023134-y665agnh 1237 7 tests test NNS cord-023134-y665agnh 1237 8 were be VBD cord-023134-y665agnh 1237 9 normal normal JJ cord-023134-y665agnh 1237 10 . . . cord-023134-y665agnh 1238 1 Ultrasonography Ultrasonography NNP cord-023134-y665agnh 1238 2 was be VBD cord-023134-y665agnh 1238 3 unremarkable unremarkable JJ cord-023134-y665agnh 1238 4 in in IN cord-023134-y665agnh 1238 5 2 2 CD cord-023134-y665agnh 1238 6 dogs dog NNS cord-023134-y665agnh 1238 7 and and CC cord-023134-y665agnh 1238 8 showed show VBD cord-023134-y665agnh 1238 9 increased increase VBN cord-023134-y665agnh 1238 10 colon colon NN cord-023134-y665agnh 1238 11 wall wall NN cord-023134-y665agnh 1238 12 thickness thickness NN cord-023134-y665agnh 1238 13 in in IN cord-023134-y665agnh 1238 14 the the DT cord-023134-y665agnh 1238 15 other other JJ cord-023134-y665agnh 1238 16 2 2 CD cord-023134-y665agnh 1238 17 . . . cord-023134-y665agnh 1239 1 Definitive definitive JJ cord-023134-y665agnh 1239 2 diagnosis diagnosis NN cord-023134-y665agnh 1239 3 was be VBD cord-023134-y665agnh 1239 4 obtained obtain VBN cord-023134-y665agnh 1239 5 from from IN cord-023134-y665agnh 1239 6 endoscopic endoscopic JJ cord-023134-y665agnh 1239 7 biopsies biopsy NNS cord-023134-y665agnh 1239 8 of of IN cord-023134-y665agnh 1239 9 the the DT cord-023134-y665agnh 1239 10 colon colon NN cord-023134-y665agnh 1239 11 and/or and/or CC cord-023134-y665agnh 1239 12 rectal rectal JJ cord-023134-y665agnh 1239 13 scrapings scraping NNS cord-023134-y665agnh 1239 14 in in IN cord-023134-y665agnh 1239 15 3 3 CD cord-023134-y665agnh 1239 16 dogs dog NNS cord-023134-y665agnh 1239 17 and and CC cord-023134-y665agnh 1239 18 from from IN cord-023134-y665agnh 1239 19 biopsies biopsy NNS cord-023134-y665agnh 1239 20 of of IN cord-023134-y665agnh 1239 21 the the DT cord-023134-y665agnh 1239 22 colon colon NN cord-023134-y665agnh 1239 23 at at IN cord-023134-y665agnh 1239 24 necropsy necropsy JJ cord-023134-y665agnh 1239 25 in in IN cord-023134-y665agnh 1239 26 one one CD cord-023134-y665agnh 1239 27 . . . cord-023134-y665agnh 1240 1 In in IN cord-023134-y665agnh 1240 2 each each DT cord-023134-y665agnh 1240 3 case case NN cord-023134-y665agnh 1240 4 spheroid spheroid NN cord-023134-y665agnh 1240 5 , , , cord-023134-y665agnh 1240 6 ovoid ovoid JJ cord-023134-y665agnh 1240 7 or or CC cord-023134-y665agnh 1240 8 irregularly irregularly RB cord-023134-y665agnh 1240 9 - - HYPH cord-023134-y665agnh 1240 10 shaped shape VBN cord-023134-y665agnh 1240 11 organisms organism NNS cord-023134-y665agnh 1240 12 suggestive suggestive JJ cord-023134-y665agnh 1240 13 of of IN cord-023134-y665agnh 1240 14 Prototheca Prototheca NNP cord-023134-y665agnh 1240 15 spp spp NNS cord-023134-y665agnh 1240 16 . . . cord-023134-y665agnh 1241 1 were be VBD cord-023134-y665agnh 1241 2 observed observe VBN cord-023134-y665agnh 1241 3 . . . cord-023134-y665agnh 1242 1 Different different JJ cord-023134-y665agnh 1242 2 treatments treatment NNS cord-023134-y665agnh 1242 3 were be VBD cord-023134-y665agnh 1242 4 attempted attempt VBN cord-023134-y665agnh 1242 5 without without IN cord-023134-y665agnh 1242 6 benefit benefit NN cord-023134-y665agnh 1242 7 in in IN cord-023134-y665agnh 1242 8 3 3 CD cord-023134-y665agnh 1242 9 dogs dog NNS cord-023134-y665agnh 1242 10 . . . cord-023134-y665agnh 1243 1 In in IN cord-023134-y665agnh 1243 2 one one CD cord-023134-y665agnh 1243 3 dog dog NN cord-023134-y665agnh 1243 4 transient transient JJ cord-023134-y665agnh 1243 5 improvement improvement NN cord-023134-y665agnh 1243 6 was be VBD cord-023134-y665agnh 1243 7 obtained obtain VBN cord-023134-y665agnh 1243 8 with with IN cord-023134-y665agnh 1243 9 itraconazole itraconazole NNP cord-023134-y665agnh 1243 10 . . . cord-023134-y665agnh 1244 1 The the DT cord-023134-y665agnh 1244 2 median median JJ cord-023134-y665agnh 1244 3 survival survival NN cord-023134-y665agnh 1244 4 time time NN cord-023134-y665agnh 1244 5 was be VBD cord-023134-y665agnh 1244 6 5 5 CD cord-023134-y665agnh 1244 7 months month NNS cord-023134-y665agnh 1245 1 ( ( -LRB- cord-023134-y665agnh 1245 2 range range NN cord-023134-y665agnh 1245 3 : : : cord-023134-y665agnh 1246 1 2 2 LS cord-023134-y665agnh 1246 2 - - SYM cord-023134-y665agnh 1246 3 12).The 12).the CD cord-023134-y665agnh 1246 4 present present JJ cord-023134-y665agnh 1246 5 work work NN cord-023134-y665agnh 1246 6 indicates indicate VBZ cord-023134-y665agnh 1246 7 that that IN cord-023134-y665agnh 1246 8 protothecosis protothecosis NN cord-023134-y665agnh 1246 9 should should MD cord-023134-y665agnh 1246 10 be be VB cord-023134-y665agnh 1246 11 included include VBN cord-023134-y665agnh 1246 12 in in IN cord-023134-y665agnh 1246 13 the the DT cord-023134-y665agnh 1246 14 list list NN cord-023134-y665agnh 1246 15 of of IN cord-023134-y665agnh 1246 16 differential differential JJ cord-023134-y665agnh 1246 17 diagnosis diagnosis NN cord-023134-y665agnh 1246 18 in in IN cord-023134-y665agnh 1246 19 dogs dog NNS cord-023134-y665agnh 1246 20 with with IN cord-023134-y665agnh 1246 21 large large JJ cord-023134-y665agnh 1246 22 bowel bowel NN cord-023134-y665agnh 1246 23 diarrhea diarrhea NN cord-023134-y665agnh 1246 24 , , , cord-023134-y665agnh 1246 25 especially especially RB cord-023134-y665agnh 1246 26 in in IN cord-023134-y665agnh 1246 27 those those DT cord-023134-y665agnh 1246 28 with with IN cord-023134-y665agnh 1246 29 chronic chronic JJ cord-023134-y665agnh 1246 30 refractory refractory JJ cord-023134-y665agnh 1246 31 colitis colitis NN cord-023134-y665agnh 1246 32 or or CC cord-023134-y665agnh 1246 33 developing develop VBG cord-023134-y665agnh 1246 34 ocular ocular JJ cord-023134-y665agnh 1246 35 signs sign NNS cord-023134-y665agnh 1246 36 . . . cord-023134-y665agnh 1247 1 Dogs dog NNS cord-023134-y665agnh 1247 2 infected infect VBN cord-023134-y665agnh 1247 3 with with IN cord-023134-y665agnh 1247 4 Prototheca Prototheca NNP cord-023134-y665agnh 1247 5 spp spp NNS cord-023134-y665agnh 1247 6 . . . cord-023134-y665agnh 1248 1 have have VB cord-023134-y665agnh 1248 2 a a DT cord-023134-y665agnh 1248 3 guarded guard VBN cord-023134-y665agnh 1248 4 prognosis prognosis NN cord-023134-y665agnh 1248 5 . . . cord-023134-y665agnh 1249 1 Diagnosing diagnose VBG cord-023134-y665agnh 1249 2 protothecosis protothecosis NN cord-023134-y665agnh 1249 3 in in IN cord-023134-y665agnh 1249 4 4 4 CD cord-023134-y665agnh 1249 5 dogs dog NNS cord-023134-y665agnh 1249 6 over over IN cord-023134-y665agnh 1249 7 a a DT cord-023134-y665agnh 1249 8 2-year 2-year CD cord-023134-y665agnh 1249 9 period period NN cord-023134-y665agnh 1249 10 may may MD cord-023134-y665agnh 1249 11 suggest suggest VB cord-023134-y665agnh 1249 12 that that IN cord-023134-y665agnh 1249 13 the the DT cord-023134-y665agnh 1249 14 disease disease NN cord-023134-y665agnh 1249 15 is be VBZ cord-023134-y665agnh 1249 16 emerging emerge VBG cord-023134-y665agnh 1249 17 in in IN cord-023134-y665agnh 1249 18 some some DT cord-023134-y665agnh 1249 19 southern southern JJ cord-023134-y665agnh 1249 20 European european JJ cord-023134-y665agnh 1249 21 countries country NNS cord-023134-y665agnh 1249 22 . . . cord-023134-y665agnh 1250 1 Idiopathic idiopathic JJ cord-023134-y665agnh 1250 2 pulmonary pulmonary JJ cord-023134-y665agnh 1250 3 fibrosis fibrosis NN cord-023134-y665agnh 1250 4 ( ( -LRB- cord-023134-y665agnh 1250 5 IPF IPF NNP cord-023134-y665agnh 1250 6 ) ) -RRB- cord-023134-y665agnh 1250 7 is be VBZ cord-023134-y665agnh 1250 8 an an DT cord-023134-y665agnh 1250 9 interstitial interstitial JJ cord-023134-y665agnh 1250 10 fibrotic fibrotic JJ cord-023134-y665agnh 1250 11 pulmonary pulmonary JJ cord-023134-y665agnh 1250 12 disease disease NN cord-023134-y665agnh 1250 13 , , , cord-023134-y665agnh 1250 14 mainly mainly RB cord-023134-y665agnh 1250 15 described describe VBN cord-023134-y665agnh 1250 16 in in IN cord-023134-y665agnh 1250 17 the the DT cord-023134-y665agnh 1250 18 West West NNP cord-023134-y665agnh 1250 19 Highland Highland NNP cord-023134-y665agnh 1250 20 White White NNP cord-023134-y665agnh 1250 21 Terrier Terrier NNP cord-023134-y665agnh 1250 22 ( ( -LRB- cord-023134-y665agnh 1250 23 WHWT WHWT NNP cord-023134-y665agnh 1250 24 ) ) -RRB- cord-023134-y665agnh 1250 25 . . . cord-023134-y665agnh 1251 1 The the DT cord-023134-y665agnh 1251 2 diagnosis diagnosis NN cord-023134-y665agnh 1251 3 is be VBZ cord-023134-y665agnh 1251 4 challenging challenging JJ cord-023134-y665agnh 1251 5 and and CC cord-023134-y665agnh 1251 6 ultimately ultimately RB cord-023134-y665agnh 1251 7 relies rely VBZ cord-023134-y665agnh 1251 8 on on IN cord-023134-y665agnh 1251 9 lung lung NN cord-023134-y665agnh 1251 10 histopathology histopathology NN cord-023134-y665agnh 1251 11 . . . cord-023134-y665agnh 1252 1 Identification identification NN cord-023134-y665agnh 1252 2 of of IN cord-023134-y665agnh 1252 3 biomarkers biomarker NNS cord-023134-y665agnh 1252 4 specific specific JJ cord-023134-y665agnh 1252 5 for for IN cord-023134-y665agnh 1252 6 the the DT cord-023134-y665agnh 1252 7 disease disease NN cord-023134-y665agnh 1252 8 would would MD cord-023134-y665agnh 1252 9 be be VB cord-023134-y665agnh 1252 10 very very RB cord-023134-y665agnh 1252 11 helpful helpful JJ cord-023134-y665agnh 1252 12 . . . cord-023134-y665agnh 1253 1 CCL2 CCL2 NNP cord-023134-y665agnh 1253 2 ( ( -LRB- cord-023134-y665agnh 1253 3 MCP-1 MCP-1 NNP cord-023134-y665agnh 1253 4 ) ) -RRB- cord-023134-y665agnh 1253 5 is be VBZ cord-023134-y665agnh 1253 6 a a DT cord-023134-y665agnh 1253 7 chemotactic chemotactic JJ cord-023134-y665agnh 1253 8 cytokine cytokine NN cord-023134-y665agnh 1253 9 for for IN cord-023134-y665agnh 1253 10 monocytes monocyte NNS cord-023134-y665agnh 1253 11 . . . cord-023134-y665agnh 1254 1 It -PRON- PRP cord-023134-y665agnh 1254 2 is be VBZ cord-023134-y665agnh 1254 3 a a DT cord-023134-y665agnh 1254 4 known know VBN cord-023134-y665agnh 1254 5 biomarker biomarker NN cord-023134-y665agnh 1254 6 in in IN cord-023134-y665agnh 1254 7 human human JJ cord-023134-y665agnh 1254 8 IPF IPF NNP cord-023134-y665agnh 1254 9 . . . cord-023134-y665agnh 1255 1 In in IN cord-023134-y665agnh 1255 2 dogs dog NNS cord-023134-y665agnh 1255 3 with with IN cord-023134-y665agnh 1255 4 IPF IPF NNP cord-023134-y665agnh 1255 5 , , , cord-023134-y665agnh 1255 6 increased increase VBD cord-023134-y665agnh 1255 7 CCL2 CCL2 NNP cord-023134-y665agnh 1255 8 gene gene NN cord-023134-y665agnh 1255 9 expression expression NN cord-023134-y665agnh 1255 10 has have VBZ cord-023134-y665agnh 1255 11 been be VBN cord-023134-y665agnh 1255 12 described describe VBN cord-023134-y665agnh 1255 13 in in IN cord-023134-y665agnh 1255 14 lung lung NN cord-023134-y665agnh 1255 15 tissue tissue NN cord-023134-y665agnh 1255 16 . . . cord-023134-y665agnh 1256 1 The the DT cord-023134-y665agnh 1256 2 aim aim NN cord-023134-y665agnh 1256 3 of of IN cord-023134-y665agnh 1256 4 the the DT cord-023134-y665agnh 1256 5 present present JJ cord-023134-y665agnh 1256 6 study study NN cord-023134-y665agnh 1256 7 was be VBD cord-023134-y665agnh 1256 8 to to TO cord-023134-y665agnh 1256 9 compare compare VB cord-023134-y665agnh 1256 10 serum serum NN cord-023134-y665agnh 1256 11 CCL2 CCL2 NNP cord-023134-y665agnh 1256 12 concentration concentration NN cord-023134-y665agnh 1256 13 in in IN cord-023134-y665agnh 1256 14 dogs dog NNS cord-023134-y665agnh 1256 15 with with IN cord-023134-y665agnh 1256 16 IPF IPF NNP cord-023134-y665agnh 1256 17 versus versus IN cord-023134-y665agnh 1256 18 healthy healthy JJ cord-023134-y665agnh 1256 19 dogs dog NNS cord-023134-y665agnh 1256 20 and and CC cord-023134-y665agnh 1256 21 dogs dog NNS cord-023134-y665agnh 1256 22 with with IN cord-023134-y665agnh 1256 23 other other JJ cord-023134-y665agnh 1256 24 chronic chronic JJ cord-023134-y665agnh 1256 25 pulmonary pulmonary JJ cord-023134-y665agnh 1256 26 diseases disease NNS cord-023134-y665agnh 1256 27 . . . cord-023134-y665agnh 1257 1 Thirteen thirteen CD cord-023134-y665agnh 1257 2 dogs dog NNS cord-023134-y665agnh 1257 3 with with IN cord-023134-y665agnh 1257 4 IPF IPF NNP cord-023134-y665agnh 1257 5 ( ( -LRB- cord-023134-y665agnh 1257 6 ten ten CD cord-023134-y665agnh 1257 7 WHWTs WHWTs NNPS cord-023134-y665agnh 1257 8 , , , cord-023134-y665agnh 1257 9 two two CD cord-023134-y665agnh 1257 10 Scottish scottish JJ cord-023134-y665agnh 1257 11 Terriers Terriers NNPS cord-023134-y665agnh 1257 12 , , , cord-023134-y665agnh 1257 13 one one CD cord-023134-y665agnh 1257 14 Yorkshire Yorkshire NNP cord-023134-y665agnh 1257 15 ) ) -RRB- cord-023134-y665agnh 1258 1 mean mean VB cord-023134-y665agnh 1259 1 age age NN cord-023134-y665agnh 1259 2 12 12 CD cord-023134-y665agnh 1259 3 years year NNS cord-023134-y665agnh 1259 4 , , , cord-023134-y665agnh 1260 1 range range NNP cord-023134-y665agnh 1260 2 8 8 CD cord-023134-y665agnh 1260 3 - - SYM cord-023134-y665agnh 1260 4 15 15 CD cord-023134-y665agnh 1260 5 ) ) -RRB- cord-023134-y665agnh 1260 6 , , , cord-023134-y665agnh 1260 7 nine nine CD cord-023134-y665agnh 1260 8 dogs dog NNS cord-023134-y665agnh 1260 9 with with IN cord-023134-y665agnh 1260 10 eosinophilic eosinophilic JJ cord-023134-y665agnh 1260 11 bronchopneumopathy bronchopneumopathy NN cord-023134-y665agnh 1260 12 ( ( -LRB- cord-023134-y665agnh 1260 13 EBP ebp NN cord-023134-y665agnh 1260 14 ) ) -RRB- cord-023134-y665agnh 1260 15 ( ( -LRB- cord-023134-y665agnh 1260 16 various various JJ cord-023134-y665agnh 1260 17 breeds breed NNS cord-023134-y665agnh 1260 18 , , , cord-023134-y665agnh 1260 19 5 5 CD cord-023134-y665agnh 1260 20 years year NNS cord-023134-y665agnh 1260 21 , , , cord-023134-y665agnh 1260 22 1 1 CD cord-023134-y665agnh 1260 23 - - SYM cord-023134-y665agnh 1260 24 12 12 CD cord-023134-y665agnh 1260 25 ) ) -RRB- cord-023134-y665agnh 1260 26 , , . cord-023134-y665agnh 1261 1 ten ten CD cord-023134-y665agnh 1261 2 dogs dog NNS cord-023134-y665agnh 1261 3 with with IN cord-023134-y665agnh 1261 4 chronic chronic JJ cord-023134-y665agnh 1261 5 bronchitis bronchitis NN cord-023134-y665agnh 1261 6 ( ( -LRB- cord-023134-y665agnh 1261 7 CB CB NNP cord-023134-y665agnh 1261 8 ) ) -RRB- cord-023134-y665agnh 1261 9 ( ( -LRB- cord-023134-y665agnh 1261 10 various various JJ cord-023134-y665agnh 1261 11 breeds breed NNS cord-023134-y665agnh 1261 12 , , , cord-023134-y665agnh 1261 13 9 9 CD cord-023134-y665agnh 1261 14 years year NNS cord-023134-y665agnh 1261 15 , , , cord-023134-y665agnh 1261 16 1 1 CD cord-023134-y665agnh 1261 17 - - SYM cord-023134-y665agnh 1261 18 13 13 CD cord-023134-y665agnh 1261 19 ) ) -RRB- cord-023134-y665agnh 1261 20 and and CC cord-023134-y665agnh 1261 21 ten ten CD cord-023134-y665agnh 1261 22 healthy healthy JJ cord-023134-y665agnh 1261 23 WHWTs whwt NNS cord-023134-y665agnh 1261 24 ( ( -LRB- cord-023134-y665agnh 1261 25 9 9 CD cord-023134-y665agnh 1261 26 years year NNS cord-023134-y665agnh 1261 27 , , , cord-023134-y665agnh 1261 28 3 3 CD cord-023134-y665agnh 1261 29 - - SYM cord-023134-y665agnh 1261 30 14 14 CD cord-023134-y665agnh 1261 31 ) ) -RRB- cord-023134-y665agnh 1261 32 entered enter VBD cord-023134-y665agnh 1261 33 the the DT cord-023134-y665agnh 1261 34 study study NN cord-023134-y665agnh 1261 35 . . . cord-023134-y665agnh 1262 1 Diagnosis diagnosis NN cord-023134-y665agnh 1262 2 was be VBD cord-023134-y665agnh 1262 3 established establish VBN cord-023134-y665agnh 1262 4 after after IN cord-023134-y665agnh 1262 5 clinical clinical JJ cord-023134-y665agnh 1262 6 , , , cord-023134-y665agnh 1262 7 radiographical radiographical JJ cord-023134-y665agnh 1262 8 , , , cord-023134-y665agnh 1262 9 bronchoscopic bronchoscopic NNP cord-023134-y665agnh 1262 10 ( ( -LRB- cord-023134-y665agnh 1262 11 and and CC cord-023134-y665agnh 1262 12 BALF BALF NNP cord-023134-y665agnh 1262 13 analysis analysis NN cord-023134-y665agnh 1262 14 ) ) -RRB- cord-023134-y665agnh 1262 15 examinations examination NNS cord-023134-y665agnh 1262 16 , , , cord-023134-y665agnh 1262 17 as as RB cord-023134-y665agnh 1262 18 well well RB cord-023134-y665agnh 1262 19 as as IN cord-023134-y665agnh 1262 20 , , , cord-023134-y665agnh 1262 21 in in IN cord-023134-y665agnh 1262 22 dogs dog NNS cord-023134-y665agnh 1262 23 with with IN cord-023134-y665agnh 1262 24 IPF IPF NNP cord-023134-y665agnh 1262 25 , , , cord-023134-y665agnh 1263 1 either either CC cord-023134-y665agnh 1263 2 lung lung NN cord-023134-y665agnh 1263 3 high high JJ cord-023134-y665agnh 1263 4 resolution resolution NN cord-023134-y665agnh 1263 5 computed compute VBD cord-023134-y665agnh 1263 6 tomography tomography NN cord-023134-y665agnh 1263 7 ( ( -LRB- cord-023134-y665agnh 1263 8 six six CD cord-023134-y665agnh 1263 9 dogs dog NNS cord-023134-y665agnh 1263 10 ) ) -RRB- cord-023134-y665agnh 1263 11 or or CC cord-023134-y665agnh 1263 12 histopathology histopathology NN cord-023134-y665agnh 1263 13 ( ( -LRB- cord-023134-y665agnh 1263 14 three three CD cord-023134-y665agnh 1263 15 dogs dog NNS cord-023134-y665agnh 1263 16 ) ) -RRB- cord-023134-y665agnh 1263 17 or or CC cord-023134-y665agnh 1263 18 both both DT cord-023134-y665agnh 1263 19 ( ( -LRB- cord-023134-y665agnh 1263 20 four four CD cord-023134-y665agnh 1263 21 dogs dog NNS cord-023134-y665agnh 1263 22 ) ) -RRB- cord-023134-y665agnh 1263 23 . . . cord-023134-y665agnh 1264 1 CCL2 ccl2 JJ cord-023134-y665agnh 1264 2 concentration concentration NN cord-023134-y665agnh 1264 3 in in IN cord-023134-y665agnh 1264 4 serum serum NN cord-023134-y665agnh 1264 5 was be VBD cord-023134-y665agnh 1264 6 determined determine VBN cord-023134-y665agnh 1264 7 by by IN cord-023134-y665agnh 1264 8 ELISA ELISA NNP cord-023134-y665agnh 1264 9 ( ( -LRB- cord-023134-y665agnh 1264 10 Canine Canine NNP cord-023134-y665agnh 1264 11 CLL2 CLL2 NNP cord-023134-y665agnh 1264 12 / / SYM cord-023134-y665agnh 1264 13 MCP-1Quantikine MCP-1Quantikine NNP cord-023134-y665agnh 1264 14 ® ® VBP cord-023134-y665agnh 1264 15 , , , cord-023134-y665agnh 1264 16 R&D R&D NNP cord-023134-y665agnh 1264 17 Sytems Sytems NNPS cord-023134-y665agnh 1264 18 ) ) -RRB- cord-023134-y665agnh 1264 19 . . . cord-023134-y665agnh 1265 1 Results result NNS cord-023134-y665agnh 1265 2 in in IN cord-023134-y665agnh 1265 3 the the DT cord-023134-y665agnh 1265 4 different different JJ cord-023134-y665agnh 1265 5 groups group NNS cord-023134-y665agnh 1265 6 were be VBD cord-023134-y665agnh 1265 7 then then RB cord-023134-y665agnh 1265 8 compared compare VBN cord-023134-y665agnh 1265 9 using use VBG cord-023134-y665agnh 1265 10 non non JJ cord-023134-y665agnh 1265 11 - - JJ cord-023134-y665agnh 1265 12 parametric parametric JJ cord-023134-y665agnh 1265 13 test test NN cord-023134-y665agnh 1265 14 ( ( -LRB- cord-023134-y665agnh 1265 15 Mann Mann NNP cord-023134-y665agnh 1265 16 - - HYPH cord-023134-y665agnh 1265 17 Whitney Whitney NNP cord-023134-y665agnh 1265 18 rank rank NN cord-023134-y665agnh 1265 19 sum sum NN cord-023134-y665agnh 1265 20 test).Serum test).Serum NNP cord-023134-y665agnh 1265 21 CCL2 CCL2 NNP cord-023134-y665agnh 1265 22 concentration concentration NN cord-023134-y665agnh 1265 23 was be VBD cord-023134-y665agnh 1265 24 elevated elevate VBN cord-023134-y665agnh 1265 25 in in IN cord-023134-y665agnh 1265 26 dogs dog NNS cord-023134-y665agnh 1265 27 with with IN cord-023134-y665agnh 1265 28 IPF IPF NNP cord-023134-y665agnh 1265 29 ( ( -LRB- cord-023134-y665agnh 1265 30 median median NN cord-023134-y665agnh 1265 31 ; ; : cord-023134-y665agnh 1265 32 interquartile interquartile JJ cord-023134-y665agnh 1265 33 range range NN cord-023134-y665agnh 1265 34 = = SYM cord-023134-y665agnh 1265 35 528.8 528.8 CD cord-023134-y665agnh 1265 36 pg pg NN cord-023134-y665agnh 1265 37 / / SYM cord-023134-y665agnh 1265 38 mL ml NN cord-023134-y665agnh 1265 39 ; ; : cord-023134-y665agnh 1265 40 444.7 444.7 CD cord-023134-y665agnh 1265 41 - - HYPH cord-023134-y665agnh 1265 42 692.0 692.0 CD cord-023134-y665agnh 1265 43 ) ) -RRB- cord-023134-y665agnh 1265 44 compared compare VBN cord-023134-y665agnh 1265 45 to to IN cord-023134-y665agnh 1265 46 healthy healthy JJ cord-023134-y665agnh 1265 47 WHWTs whwt NNS cord-023134-y665agnh 1265 48 ( ( -LRB- cord-023134-y665agnh 1265 49 344.0 344.0 CD cord-023134-y665agnh 1265 50 ; ; : cord-023134-y665agnh 1265 51 254.5 254.5 CD cord-023134-y665agnh 1265 52 - - HYPH cord-023134-y665agnh 1265 53 415.5 415.5 CD cord-023134-y665agnh 1265 54 ) ) -RRB- cord-023134-y665agnh 1265 55 , , , cord-023134-y665agnh 1265 56 ( ( -LRB- cord-023134-y665agnh 1265 57 p<0.001 p<0.001 CD cord-023134-y665agnh 1265 58 ) ) -RRB- cord-023134-y665agnh 1265 59 . . . cord-023134-y665agnh 1266 1 Serum serum NN cord-023134-y665agnh 1266 2 CCL2 CCL2 NNP cord-023134-y665agnh 1266 3 value value NN cord-023134-y665agnh 1266 4 in in IN cord-023134-y665agnh 1266 5 IPF IPF NNP cord-023134-y665agnh 1266 6 dogs dog NNS cord-023134-y665agnh 1266 7 was be VBD cord-023134-y665agnh 1266 8 higher high JJR cord-023134-y665agnh 1266 9 than than IN cord-023134-y665agnh 1266 10 in in IN cord-023134-y665agnh 1266 11 EBP ebp NN cord-023134-y665agnh 1266 12 dogs dog NNS cord-023134-y665agnh 1266 13 ( ( -LRB- cord-023134-y665agnh 1266 14 281.6 281.6 CD cord-023134-y665agnh 1266 15 ; ; : cord-023134-y665agnh 1266 16 163.9 163.9 CD cord-023134-y665agnh 1266 17 - - HYPH cord-023134-y665agnh 1266 18 416.5 416.5 CD cord-023134-y665agnh 1266 19 ) ) -RRB- cord-023134-y665agnh 1266 20 ( ( -LRB- cord-023134-y665agnh 1266 21 p=0.009 p=0.009 NN cord-023134-y665agnh 1266 22 ) ) -RRB- cord-023134-y665agnh 1266 23 and and CC cord-023134-y665agnh 1266 24 than than IN cord-023134-y665agnh 1266 25 in in IN cord-023134-y665agnh 1266 26 CB CB NNP cord-023134-y665agnh 1266 27 dogs dog NNS cord-023134-y665agnh 1266 28 ( ( -LRB- cord-023134-y665agnh 1266 29 277.7 277.7 CD cord-023134-y665agnh 1266 30 ; ; : cord-023134-y665agnh 1266 31 137.3 137.3 CD cord-023134-y665agnh 1266 32 - - HYPH cord-023134-y665agnh 1266 33 364.7 364.7 CD cord-023134-y665agnh 1266 34 ) ) -RRB- cord-023134-y665agnh 1267 1 ( ( -LRB- cord-023134-y665agnh 1267 2 p=0.003).The p=0.003).the JJ cord-023134-y665agnh 1267 3 present present JJ cord-023134-y665agnh 1267 4 study study NN cord-023134-y665agnh 1267 5 shows show VBZ cord-023134-y665agnh 1267 6 that that IN cord-023134-y665agnh 1267 7 ( ( -LRB- cord-023134-y665agnh 1267 8 1 1 LS cord-023134-y665agnh 1267 9 ) ) -RRB- cord-023134-y665agnh 1267 10 Idiopathic idiopathic JJ cord-023134-y665agnh 1267 11 pulmonary pulmonary JJ cord-023134-y665agnh 1267 12 fibrosis fibrosis NN cord-023134-y665agnh 1267 13 ( ( -LRB- cord-023134-y665agnh 1267 14 IPF IPF NNP cord-023134-y665agnh 1267 15 ) ) -RRB- cord-023134-y665agnh 1267 16 is be VBZ cord-023134-y665agnh 1267 17 a a DT cord-023134-y665agnh 1267 18 progressive progressive JJ cord-023134-y665agnh 1267 19 interstitial interstitial JJ cord-023134-y665agnh 1267 20 fibrotic fibrotic JJ cord-023134-y665agnh 1267 21 disease disease NN cord-023134-y665agnh 1267 22 , , , cord-023134-y665agnh 1267 23 described describe VBN cord-023134-y665agnh 1267 24 in in IN cord-023134-y665agnh 1267 25 humans human NNS cord-023134-y665agnh 1267 26 and and CC cord-023134-y665agnh 1267 27 in in IN cord-023134-y665agnh 1267 28 dogs dog NNS cord-023134-y665agnh 1267 29 . . . cord-023134-y665agnh 1268 1 Etiology etiology NN cord-023134-y665agnh 1268 2 and and CC cord-023134-y665agnh 1268 3 pathogenesis pathogenesis NN cord-023134-y665agnh 1268 4 of of IN cord-023134-y665agnh 1268 5 IPF IPF NNP cord-023134-y665agnh 1268 6 are be VBP cord-023134-y665agnh 1268 7 poorly poorly RB cord-023134-y665agnh 1268 8 known know VBN cord-023134-y665agnh 1268 9 in in IN cord-023134-y665agnh 1268 10 both both DT cord-023134-y665agnh 1268 11 species specie NNS cord-023134-y665agnh 1268 12 , , , cord-023134-y665agnh 1268 13 even even RB cord-023134-y665agnh 1268 14 if if IN cord-023134-y665agnh 1268 15 a a DT cord-023134-y665agnh 1268 16 genetic genetic JJ cord-023134-y665agnh 1268 17 basis basis NN cord-023134-y665agnh 1268 18 is be VBZ cord-023134-y665agnh 1268 19 suspected suspect VBN cord-023134-y665agnh 1268 20 in in IN cord-023134-y665agnh 1268 21 dogs dog NNS cord-023134-y665agnh 1268 22 because because IN cord-023134-y665agnh 1268 23 of of IN cord-023134-y665agnh 1268 24 the the DT cord-023134-y665agnh 1268 25 predisposition predisposition NN cord-023134-y665agnh 1268 26 of of IN cord-023134-y665agnh 1268 27 the the DT cord-023134-y665agnh 1268 28 West West NNP cord-023134-y665agnh 1268 29 Highland Highland NNP cord-023134-y665agnh 1268 30 white white JJ cord-023134-y665agnh 1268 31 terrier terrier NNP cord-023134-y665agnh 1268 32 ( ( -LRB- cord-023134-y665agnh 1268 33 WHWT WHWT NNP cord-023134-y665agnh 1268 34 ) ) -RRB- cord-023134-y665agnh 1268 35 . . . cord-023134-y665agnh 1269 1 Serum serum NN cord-023134-y665agnh 1269 2 transforming transform VBG cord-023134-y665agnh 1269 3 growth growth NN cord-023134-y665agnh 1269 4 factor factor NN cord-023134-y665agnh 1269 5 beta beta NN cord-023134-y665agnh 1269 6 1 1 CD cord-023134-y665agnh 1270 1 ( ( -LRB- cord-023134-y665agnh 1270 2 TGFB1 TGFB1 NNP cord-023134-y665agnh 1270 3 ) ) -RRB- cord-023134-y665agnh 1270 4 concentration concentration NN cord-023134-y665agnh 1270 5 is be VBZ cord-023134-y665agnh 1270 6 elevated elevate VBN cord-023134-y665agnh 1270 7 in in IN cord-023134-y665agnh 1270 8 both both DT cord-023134-y665agnh 1270 9 healthy healthy JJ cord-023134-y665agnh 1270 10 WHWTs whwt NNS cord-023134-y665agnh 1270 11 and and CC cord-023134-y665agnh 1270 12 WHWTs WHWTs NNPS cord-023134-y665agnh 1270 13 with with IN cord-023134-y665agnh 1270 14 IPF IPF NNP cord-023134-y665agnh 1270 15 , , , cord-023134-y665agnh 1270 16 as as IN cord-023134-y665agnh 1270 17 compared compare VBN cord-023134-y665agnh 1270 18 to to IN cord-023134-y665agnh 1270 19 healthy healthy JJ cord-023134-y665agnh 1270 20 dogs dog NNS cord-023134-y665agnh 1270 21 of of IN cord-023134-y665agnh 1270 22 various various JJ cord-023134-y665agnh 1270 23 breeds breed NNS cord-023134-y665agnh 1270 24 . . . cord-023134-y665agnh 1271 1 In in IN cord-023134-y665agnh 1271 2 human human JJ cord-023134-y665agnh 1271 3 IPF IPF NNP cord-023134-y665agnh 1271 4 , , , cord-023134-y665agnh 1271 5 pathways pathway NNS cord-023134-y665agnh 1271 6 involving involve VBG cord-023134-y665agnh 1271 7 TGFB1 TGFB1 NNP cord-023134-y665agnh 1271 8 , , , cord-023134-y665agnh 1271 9 a a DT cord-023134-y665agnh 1271 10 cytokine cytokine NN cord-023134-y665agnh 1271 11 with with IN cord-023134-y665agnh 1271 12 profibrotic profibrotic JJ cord-023134-y665agnh 1271 13 properties property NNS cord-023134-y665agnh 1271 14 , , , cord-023134-y665agnh 1271 15 seem seem VBP cord-023134-y665agnh 1271 16 to to TO cord-023134-y665agnh 1271 17 be be VB cord-023134-y665agnh 1271 18 central central JJ cord-023134-y665agnh 1271 19 in in IN cord-023134-y665agnh 1271 20 the the DT cord-023134-y665agnh 1271 21 pathogenesis pathogenesis NN cord-023134-y665agnh 1271 22 and and CC cord-023134-y665agnh 1271 23 are be VBP cord-023134-y665agnh 1271 24 considered consider VBN cord-023134-y665agnh 1271 25 as as IN cord-023134-y665agnh 1271 26 potential potential JJ cord-023134-y665agnh 1271 27 therapeutic therapeutic JJ cord-023134-y665agnh 1271 28 targets target NNS cord-023134-y665agnh 1271 29 . . . cord-023134-y665agnh 1272 1 TGFB1 TGFB1 NNP cord-023134-y665agnh 1272 2 is be VBZ cord-023134-y665agnh 1272 3 produced produce VBN cord-023134-y665agnh 1272 4 as as IN cord-023134-y665agnh 1272 5 a a DT cord-023134-y665agnh 1272 6 pro pro JJ cord-023134-y665agnh 1272 7 - - JJ cord-023134-y665agnh 1272 8 protein protein JJ cord-023134-y665agnh 1272 9 and and CC cord-023134-y665agnh 1272 10 usually usually RB cord-023134-y665agnh 1272 11 stored store VBN cord-023134-y665agnh 1272 12 as as IN cord-023134-y665agnh 1272 13 a a DT cord-023134-y665agnh 1272 14 latent latent JJ cord-023134-y665agnh 1272 15 complex complex NN cord-023134-y665agnh 1272 16 . . . cord-023134-y665agnh 1273 1 Activation activation NN cord-023134-y665agnh 1273 2 of of IN cord-023134-y665agnh 1273 3 the the DT cord-023134-y665agnh 1273 4 latent latent JJ cord-023134-y665agnh 1273 5 complex complex NN cord-023134-y665agnh 1273 6 is be VBZ cord-023134-y665agnh 1273 7 an an DT cord-023134-y665agnh 1273 8 important important JJ cord-023134-y665agnh 1273 9 step step NN cord-023134-y665agnh 1273 10 that that WDT cord-023134-y665agnh 1273 11 regulates regulate VBZ cord-023134-y665agnh 1273 12 TGFB1 TGFB1 NNP cord-023134-y665agnh 1273 13 function function NN cord-023134-y665agnh 1273 14 . . . cord-023134-y665agnh 1274 1 Multiple multiple JJ cord-023134-y665agnh 1274 2 activation activation NN cord-023134-y665agnh 1274 3 mechanisms mechanism NNS cord-023134-y665agnh 1274 4 have have VBP cord-023134-y665agnh 1274 5 been be VBN cord-023134-y665agnh 1274 6 identified identify VBN cord-023134-y665agnh 1274 7 including include VBG cord-023134-y665agnh 1274 8 binding bind VBG cord-023134-y665agnh 1274 9 to to IN cord-023134-y665agnh 1274 10 integrins integrin NNS cord-023134-y665agnh 1274 11 and and CC cord-023134-y665agnh 1274 12 thrombospondin thrombospondin NNP cord-023134-y665agnh 1274 13 1 1 CD cord-023134-y665agnh 1275 1 ( ( -LRB- cord-023134-y665agnh 1275 2 THBS1).The THBS1).The NNP cord-023134-y665agnh 1275 3 aim aim NN cord-023134-y665agnh 1275 4 of of IN cord-023134-y665agnh 1275 5 the the DT cord-023134-y665agnh 1275 6 present present JJ cord-023134-y665agnh 1275 7 study study NN cord-023134-y665agnh 1275 8 was be VBD cord-023134-y665agnh 1275 9 to to TO cord-023134-y665agnh 1275 10 quantify quantify VB cord-023134-y665agnh 1275 11 TGFB1 TGFB1 NNP cord-023134-y665agnh 1275 12 expression expression NN cord-023134-y665agnh 1275 13 , , , cord-023134-y665agnh 1275 14 as as RB cord-023134-y665agnh 1275 15 well well RB cord-023134-y665agnh 1275 16 as as IN cord-023134-y665agnh 1275 17 expression expression NN cord-023134-y665agnh 1275 18 of of IN cord-023134-y665agnh 1275 19 proteins protein NNS cord-023134-y665agnh 1275 20 involved involve VBN cord-023134-y665agnh 1275 21 in in IN cord-023134-y665agnh 1275 22 TGFB1 TGFB1 NNP cord-023134-y665agnh 1275 23 activation activation NN cord-023134-y665agnh 1275 24 , , , cord-023134-y665agnh 1275 25 by by IN cord-023134-y665agnh 1275 26 quantitative quantitative JJ cord-023134-y665agnh 1275 27 RT RT NNP cord-023134-y665agnh 1275 28 - - HYPH cord-023134-y665agnh 1275 29 PCR PCR NNP cord-023134-y665agnh 1275 30 , , , cord-023134-y665agnh 1275 31 in in IN cord-023134-y665agnh 1275 32 lung lung NN cord-023134-y665agnh 1275 33 tissue tissue NN cord-023134-y665agnh 1275 34 from from IN cord-023134-y665agnh 1275 35 dogs dog NNS cord-023134-y665agnh 1275 36 with with IN cord-023134-y665agnh 1275 37 IPF IPF NNP cord-023134-y665agnh 1275 38 versus versus IN cord-023134-y665agnh 1275 39 control control NN cord-023134-y665agnh 1275 40 dogs dog NNS cord-023134-y665agnh 1275 41 . . . cord-023134-y665agnh 1276 1 Total Total NNP cord-023134-y665agnh 1276 2 RNA RNA NNP cord-023134-y665agnh 1276 3 was be VBD cord-023134-y665agnh 1276 4 extracted extract VBN cord-023134-y665agnh 1276 5 from from IN cord-023134-y665agnh 1276 6 lung lung NN cord-023134-y665agnh 1276 7 tissues tissue NNS cord-023134-y665agnh 1276 8 from from IN cord-023134-y665agnh 1276 9 14 14 CD cord-023134-y665agnh 1276 10 dogs dog NNS cord-023134-y665agnh 1276 11 with with IN cord-023134-y665agnh 1276 12 IPF IPF NNP cord-023134-y665agnh 1276 13 ( ( -LRB- cord-023134-y665agnh 1276 14 12 12 CD cord-023134-y665agnh 1276 15 WHWTs whwt NNS cord-023134-y665agnh 1276 16 , , , cord-023134-y665agnh 1276 17 1 1 CD cord-023134-y665agnh 1276 18 Scottish scottish JJ cord-023134-y665agnh 1276 19 terrier terrier NN cord-023134-y665agnh 1276 20 , , , cord-023134-y665agnh 1276 21 1 1 CD cord-023134-y665agnh 1276 22 Lhassa Lhassa NNP cord-023134-y665agnh 1276 23 Apso Apso NNP cord-023134-y665agnh 1276 24 ) ) -RRB- cord-023134-y665agnh 1276 25 and and CC cord-023134-y665agnh 1276 26 11 11 CD cord-023134-y665agnh 1276 27 control control NN cord-023134-y665agnh 1276 28 dogs dog NNS cord-023134-y665agnh 1276 29 ( ( -LRB- cord-023134-y665agnh 1276 30 various various JJ cord-023134-y665agnh 1276 31 breeds breed NNS cord-023134-y665agnh 1276 32 ) ) -RRB- cord-023134-y665agnh 1276 33 . . . cord-023134-y665agnh 1277 1 IPF IPF NNP cord-023134-y665agnh 1277 2 was be VBD cord-023134-y665agnh 1277 3 confirmed confirm VBN cord-023134-y665agnh 1277 4 by by IN cord-023134-y665agnh 1277 5 histopathology histopathology NN cord-023134-y665agnh 1277 6 on on IN cord-023134-y665agnh 1277 7 all all DT cord-023134-y665agnh 1277 8 samples sample NNS cord-023134-y665agnh 1277 9 . . . cord-023134-y665agnh 1278 1 Expression expression NN cord-023134-y665agnh 1278 2 of of IN cord-023134-y665agnh 1278 3 TGFB1 TGFB1 NNP cord-023134-y665agnh 1278 4 , , , cord-023134-y665agnh 1278 5 2 2 CD cord-023134-y665agnh 1278 6 integrins integrin NNS cord-023134-y665agnh 1278 7 ( ( -LRB- cord-023134-y665agnh 1278 8 ITGB6 itgb6 NN cord-023134-y665agnh 1278 9 and and CC cord-023134-y665agnh 1278 10 ITGB8 ITGB8 NNP cord-023134-y665agnh 1278 11 ) ) -RRB- cord-023134-y665agnh 1278 12 and and CC cord-023134-y665agnh 1278 13 THBS1 thbs1 PRP cord-023134-y665agnh 1278 14 was be VBD cord-023134-y665agnh 1278 15 measured measure VBN cord-023134-y665agnh 1278 16 by by IN cord-023134-y665agnh 1278 17 qRT qRT NNP cord-023134-y665agnh 1278 18 - - HYPH cord-023134-y665agnh 1278 19 PCR PCR NNP cord-023134-y665agnh 1278 20 . . . cord-023134-y665agnh 1279 1 For for IN cord-023134-y665agnh 1279 2 each each DT cord-023134-y665agnh 1279 3 gene gene NN cord-023134-y665agnh 1279 4 , , , cord-023134-y665agnh 1279 5 a a DT cord-023134-y665agnh 1279 6 relative relative JJ cord-023134-y665agnh 1279 7 copy copy NN cord-023134-y665agnh 1279 8 number number NN cord-023134-y665agnh 1279 9 was be VBD cord-023134-y665agnh 1279 10 calculated calculate VBN cord-023134-y665agnh 1279 11 for for IN cord-023134-y665agnh 1279 12 each each DT cord-023134-y665agnh 1279 13 sample sample NN cord-023134-y665agnh 1279 14 and and CC cord-023134-y665agnh 1279 15 results result NNS cord-023134-y665agnh 1279 16 were be VBD cord-023134-y665agnh 1279 17 normalised normalise VBN cord-023134-y665agnh 1279 18 using use VBG cord-023134-y665agnh 1279 19 two two CD cord-023134-y665agnh 1279 20 stably stably RB cord-023134-y665agnh 1279 21 expressed express VBD cord-023134-y665agnh 1279 22 housekeeper housekeeper NN cord-023134-y665agnh 1279 23 genes gene NNS cord-023134-y665agnh 1279 24 ( ( -LRB- cord-023134-y665agnh 1279 25 RPS18 RPS18 NNP cord-023134-y665agnh 1279 26 and and CC cord-023134-y665agnh 1279 27 TBP TBP NNP cord-023134-y665agnh 1279 28 ) ) -RRB- cord-023134-y665agnh 1279 29 . . . cord-023134-y665agnh 1280 1 Statistically statistically RB cord-023134-y665agnh 1280 2 significant significant JJ cord-023134-y665agnh 1280 3 differences difference NNS cord-023134-y665agnh 1280 4 between between IN cord-023134-y665agnh 1280 5 the the DT cord-023134-y665agnh 1280 6 groups group NNS cord-023134-y665agnh 1280 7 were be VBD cord-023134-y665agnh 1280 8 assessed assess VBN cord-023134-y665agnh 1280 9 using use VBG cord-023134-y665agnh 1280 10 a a DT cord-023134-y665agnh 1280 11 Student Student NNP cord-023134-y665agnh 1280 12 t t NN cord-023134-y665agnh 1280 13 - - HYPH cord-023134-y665agnh 1280 14 test test NN cord-023134-y665agnh 1280 15 or or CC cord-023134-y665agnh 1280 16 a a DT cord-023134-y665agnh 1280 17 Mann Mann NNP cord-023134-y665agnh 1280 18 - - HYPH cord-023134-y665agnh 1280 19 Whitney Whitney NNP cord-023134-y665agnh 1280 20 Rank Rank NNP cord-023134-y665agnh 1280 21 sum sum NN cord-023134-y665agnh 1280 22 test test NN cord-023134-y665agnh 1280 23 with with IN cord-023134-y665agnh 1280 24 significance significance NN cord-023134-y665agnh 1280 25 defined define VBN cord-023134-y665agnh 1280 26 as as IN cord-023134-y665agnh 1280 27 a a DT cord-023134-y665agnh 1280 28 p p NN cord-023134-y665agnh 1280 29 < < XX cord-023134-y665agnh 1280 30 0.05.Expression 0.05.expression NN cord-023134-y665agnh 1280 31 of of IN cord-023134-y665agnh 1280 32 TGFB1 TGFB1 NNP cord-023134-y665agnh 1281 1 and and CC cord-023134-y665agnh 1281 2 ITGB6 ITGB6 NNP cord-023134-y665agnh 1281 3 was be VBD cord-023134-y665agnh 1281 4 not not RB cord-023134-y665agnh 1281 5 statistically statistically RB cord-023134-y665agnh 1281 6 different different JJ cord-023134-y665agnh 1281 7 between between IN cord-023134-y665agnh 1281 8 the the DT cord-023134-y665agnh 1281 9 two two CD cord-023134-y665agnh 1281 10 groups group NNS cord-023134-y665agnh 1281 11 . . . cord-023134-y665agnh 1282 1 Expression expression NN cord-023134-y665agnh 1282 2 of of IN cord-023134-y665agnh 1282 3 ITGB8 ITGB8 NNP cord-023134-y665agnh 1282 4 was be VBD cord-023134-y665agnh 1282 5 significantly significantly RB cord-023134-y665agnh 1282 6 lower low JJR cord-023134-y665agnh 1282 7 ( ( -LRB- cord-023134-y665agnh 1282 8 p<0.001 p<0.001 NNS cord-023134-y665agnh 1282 9 ) ) -RRB- cord-023134-y665agnh 1282 10 while while IN cord-023134-y665agnh 1282 11 THBS1 thbs1 DT cord-023134-y665agnh 1282 12 expression expression NN cord-023134-y665agnh 1282 13 was be VBD cord-023134-y665agnh 1282 14 significantly significantly RB cord-023134-y665agnh 1282 15 higher high JJR cord-023134-y665agnh 1282 16 ( ( -LRB- cord-023134-y665agnh 1282 17 p=0.016 p=0.016 JJS cord-023134-y665agnh 1282 18 ) ) -RRB- cord-023134-y665agnh 1282 19 in in IN cord-023134-y665agnh 1282 20 the the DT cord-023134-y665agnh 1282 21 IPF IPF NNP cord-023134-y665agnh 1282 22 group group NN cord-023134-y665agnh 1282 23 relative relative JJ cord-023134-y665agnh 1282 24 to to IN cord-023134-y665agnh 1282 25 controls control NNS cord-023134-y665agnh 1282 26 . . . cord-023134-y665agnh 1283 1 Results result NNS cord-023134-y665agnh 1283 2 of of IN cord-023134-y665agnh 1283 3 the the DT cord-023134-y665agnh 1283 4 present present JJ cord-023134-y665agnh 1283 5 study study NN cord-023134-y665agnh 1283 6 could could MD cord-023134-y665agnh 1283 7 not not RB cord-023134-y665agnh 1283 8 confirm confirm VB cord-023134-y665agnh 1283 9 that that IN cord-023134-y665agnh 1283 10 increased increase VBN cord-023134-y665agnh 1283 11 gene gene NN cord-023134-y665agnh 1283 12 expression expression NN cord-023134-y665agnh 1283 13 of of IN cord-023134-y665agnh 1283 14 TGFB1 TGFB1 NNP cord-023134-y665agnh 1283 15 by by IN cord-023134-y665agnh 1283 16 lung lung NN cord-023134-y665agnh 1283 17 tissue tissue NN cord-023134-y665agnh 1283 18 is be VBZ cord-023134-y665agnh 1283 19 the the DT cord-023134-y665agnh 1283 20 source source NN cord-023134-y665agnh 1283 21 of of IN cord-023134-y665agnh 1283 22 the the DT cord-023134-y665agnh 1283 23 high high JJ cord-023134-y665agnh 1283 24 circulating circulate VBG cord-023134-y665agnh 1283 25 TGFB1 TGFB1 NNP cord-023134-y665agnh 1283 26 level level NN cord-023134-y665agnh 1283 27 in in IN cord-023134-y665agnh 1283 28 IPF IPF NNP cord-023134-y665agnh 1283 29 . . . cord-023134-y665agnh 1284 1 This this DT cord-023134-y665agnh 1284 2 study study NN cord-023134-y665agnh 1284 3 highlights highlight VBZ cord-023134-y665agnh 1284 4 different different JJ cord-023134-y665agnh 1284 5 activating activate VBG cord-023134-y665agnh 1284 6 pathways pathway NNS cord-023134-y665agnh 1284 7 of of IN cord-023134-y665agnh 1284 8 TGFB1 TGFB1 NNP cord-023134-y665agnh 1284 9 in in IN cord-023134-y665agnh 1284 10 IPF IPF NNP cord-023134-y665agnh 1284 11 lungs lung NNS cord-023134-y665agnh 1284 12 compared compare VBN cord-023134-y665agnh 1284 13 to to TO cord-023134-y665agnh 1284 14 control control VB cord-023134-y665agnh 1284 15 lungs lung NNS cord-023134-y665agnh 1284 16 with with IN cord-023134-y665agnh 1284 17 a a DT cord-023134-y665agnh 1284 18 shift shift NN cord-023134-y665agnh 1284 19 toward toward IN cord-023134-y665agnh 1284 20 an an DT cord-023134-y665agnh 1284 21 increased increase VBN cord-023134-y665agnh 1284 22 activation activation NN cord-023134-y665agnh 1284 23 via via IN cord-023134-y665agnh 1284 24 THBS1 thbs1 NN cord-023134-y665agnh 1284 25 in in IN cord-023134-y665agnh 1284 26 canine canine JJ cord-023134-y665agnh 1284 27 IPF IPF NNP cord-023134-y665agnh 1284 28 . . . cord-023134-y665agnh 1285 1 Obesity obesity NN cord-023134-y665agnh 1285 2 is be VBZ cord-023134-y665agnh 1285 3 the the DT cord-023134-y665agnh 1285 4 most most RBS cord-023134-y665agnh 1285 5 common common JJ cord-023134-y665agnh 1285 6 nutritional nutritional JJ cord-023134-y665agnh 1285 7 problem problem NN cord-023134-y665agnh 1285 8 in in IN cord-023134-y665agnh 1285 9 dogs dog NNS cord-023134-y665agnh 1285 10 , , , cord-023134-y665agnh 1285 11 and and CC cord-023134-y665agnh 1285 12 its -PRON- PRP$ cord-023134-y665agnh 1285 13 detrimental detrimental JJ cord-023134-y665agnh 1285 14 effect effect NN cord-023134-y665agnh 1285 15 on on IN cord-023134-y665agnh 1285 16 basal basal NN cord-023134-y665agnh 1285 17 lung lung NN cord-023134-y665agnh 1285 18 function function NN cord-023134-y665agnh 1285 19 parameters parameter NNS cord-023134-y665agnh 1285 20 has have VBZ cord-023134-y665agnh 1285 21 been be VBN cord-023134-y665agnh 1285 22 recently recently RB cord-023134-y665agnh 1285 23 shown show VBN cord-023134-y665agnh 1285 24 using use VBG cord-023134-y665agnh 1285 25 whole whole JJ cord-023134-y665agnh 1285 26 - - HYPH cord-023134-y665agnh 1285 27 body body NN cord-023134-y665agnh 1285 28 barometric barometric NN cord-023134-y665agnh 1285 29 plethysmography plethysmography NN cord-023134-y665agnh 1285 30 . . . cord-023134-y665agnh 1286 1 The the DT cord-023134-y665agnh 1286 2 6-Minute 6-minute CD cord-023134-y665agnh 1286 3 Walk walk NN cord-023134-y665agnh 1286 4 Test Test NNP cord-023134-y665agnh 1286 5 ( ( -LRB- cord-023134-y665agnh 1286 6 6MWT 6MWT NNP cord-023134-y665agnh 1286 7 ) ) -RRB- cord-023134-y665agnh 1286 8 has have VBZ cord-023134-y665agnh 1286 9 been be VBN cord-023134-y665agnh 1286 10 recently recently RB cord-023134-y665agnh 1286 11 demonstrated demonstrate VBN cord-023134-y665agnh 1286 12 to to TO cord-023134-y665agnh 1286 13 be be VB cord-023134-y665agnh 1286 14 a a DT cord-023134-y665agnh 1286 15 non non JJ cord-023134-y665agnh 1286 16 - - JJ cord-023134-y665agnh 1286 17 invasive invasive JJ cord-023134-y665agnh 1286 18 easy easy JJ cord-023134-y665agnh 1286 19 - - HYPH cord-023134-y665agnh 1286 20 to to TO cord-023134-y665agnh 1286 21 - - HYPH cord-023134-y665agnh 1286 22 perform perform VB cord-023134-y665agnh 1286 23 test test NN cord-023134-y665agnh 1286 24 in in IN cord-023134-y665agnh 1286 25 clinical clinical JJ cord-023134-y665agnh 1286 26 settings setting NNS cord-023134-y665agnh 1286 27 , , , cord-023134-y665agnh 1286 28 able able JJ cord-023134-y665agnh 1286 29 to to TO cord-023134-y665agnh 1286 30 discriminate discriminate VB cord-023134-y665agnh 1286 31 between between IN cord-023134-y665agnh 1286 32 healthy healthy JJ cord-023134-y665agnh 1286 33 dogs dog NNS cord-023134-y665agnh 1286 34 and and CC cord-023134-y665agnh 1286 35 dogs dog NNS cord-023134-y665agnh 1286 36 with with IN cord-023134-y665agnh 1286 37 pulmonary pulmonary JJ cord-023134-y665agnh 1286 38 disease disease NN cord-023134-y665agnh 1286 39 . . . cord-023134-y665agnh 1287 1 The the DT cord-023134-y665agnh 1287 2 aim aim NN cord-023134-y665agnh 1287 3 of of IN cord-023134-y665agnh 1287 4 this this DT cord-023134-y665agnh 1287 5 study study NN cord-023134-y665agnh 1287 6 was be VBD cord-023134-y665agnh 1287 7 to to TO cord-023134-y665agnh 1287 8 investigate investigate VB cord-023134-y665agnh 1287 9 the the DT cord-023134-y665agnh 1287 10 effect effect NN cord-023134-y665agnh 1287 11 of of IN cord-023134-y665agnh 1287 12 body body NN cord-023134-y665agnh 1287 13 weight weight NN cord-023134-y665agnh 1287 14 loss loss NN cord-023134-y665agnh 1287 15 ( ( -LRB- cord-023134-y665agnh 1287 16 BWL BWL NNP cord-023134-y665agnh 1287 17 ) ) -RRB- cord-023134-y665agnh 1287 18 on on IN cord-023134-y665agnh 1287 19 pulmonary pulmonary JJ cord-023134-y665agnh 1287 20 function function NN cord-023134-y665agnh 1287 21 assessed assess VBN cord-023134-y665agnh 1287 22 by by IN cord-023134-y665agnh 1287 23 6MWT 6MWT NNP cord-023134-y665agnh 1287 24 and and CC cord-023134-y665agnh 1287 25 arterial arterial JJ cord-023134-y665agnh 1287 26 blood blood NN cord-023134-y665agnh 1287 27 gas gas NN cord-023134-y665agnh 1287 28 values value NNS cord-023134-y665agnh 1287 29 . . . cord-023134-y665agnh 1288 1 Six six CD cord-023134-y665agnh 1288 2 experimental experimental JJ cord-023134-y665agnh 1288 3 Beagles beagle NNS cord-023134-y665agnh 1288 4 and and CC cord-023134-y665agnh 1288 5 6 6 CD cord-023134-y665agnh 1288 6 privately privately RB cord-023134-y665agnh 1288 7 - - HYPH cord-023134-y665agnh 1288 8 owned own VBN cord-023134-y665agnh 1288 9 dogs dog NNS cord-023134-y665agnh 1288 10 , , , cord-023134-y665agnh 1288 11 all all DT cord-023134-y665agnh 1288 12 obese obese JJ cord-023134-y665agnh 1288 13 but but CC cord-023134-y665agnh 1288 14 otherwise otherwise RB cord-023134-y665agnh 1288 15 healthy healthy JJ cord-023134-y665agnh 1288 16 , , , cord-023134-y665agnh 1288 17 were be VBD cord-023134-y665agnh 1288 18 enrolled enrol VBN cord-023134-y665agnh 1288 19 in in IN cord-023134-y665agnh 1288 20 a a DT cord-023134-y665agnh 1288 21 diet diet NN cord-023134-y665agnh 1288 22 - - HYPH cord-023134-y665agnh 1288 23 induced induce VBN cord-023134-y665agnh 1288 24 BWL BWL NNP cord-023134-y665agnh 1288 25 program program NN cord-023134-y665agnh 1288 26 . . . cord-023134-y665agnh 1289 1 Physical physical JJ cord-023134-y665agnh 1289 2 examination examination NN cord-023134-y665agnh 1289 3 , , , cord-023134-y665agnh 1289 4 BW BW NNP cord-023134-y665agnh 1289 5 and and CC cord-023134-y665agnh 1289 6 Body Body NNP cord-023134-y665agnh 1289 7 Condition Condition NNP cord-023134-y665agnh 1289 8 Score Score NNP cord-023134-y665agnh 1289 9 ( ( -LRB- cord-023134-y665agnh 1289 10 BCS BCS NNP cord-023134-y665agnh 1289 11 ) ) -RRB- cord-023134-y665agnh 1289 12 assessment assessment NN cord-023134-y665agnh 1289 13 , , , cord-023134-y665agnh 1289 14 arterial arterial JJ cord-023134-y665agnh 1289 15 blood blood NN cord-023134-y665agnh 1289 16 gas gas NN cord-023134-y665agnh 1289 17 analysis analysis NN cord-023134-y665agnh 1289 18 and and CC cord-023134-y665agnh 1289 19 6MWT 6MWT NNP cord-023134-y665agnh 1289 20 were be VBD cord-023134-y665agnh 1289 21 performed perform VBN cord-023134-y665agnh 1289 22 when when WRB cord-023134-y665agnh 1289 23 dogs dog NNS cord-023134-y665agnh 1289 24 were be VBD cord-023134-y665agnh 1289 25 obese obese JJ cord-023134-y665agnh 1289 26 ( ( -LRB- cord-023134-y665agnh 1289 27 BCS BCS NNP cord-023134-y665agnh 1289 28 8 8 CD cord-023134-y665agnh 1289 29 - - SYM cord-023134-y665agnh 1289 30 9/9 9/9 CD cord-023134-y665agnh 1289 31 ) ) -RRB- cord-023134-y665agnh 1289 32 , , , cord-023134-y665agnh 1289 33 and and CC cord-023134-y665agnh 1289 34 repeated repeat VBN cord-023134-y665agnh 1289 35 with with IN cord-023134-y665agnh 1289 36 animals animal NNS cord-023134-y665agnh 1289 37 in in IN cord-023134-y665agnh 1289 38 the the DT cord-023134-y665agnh 1289 39 middle middle NN cord-023134-y665agnh 1289 40 of of IN cord-023134-y665agnh 1289 41 their -PRON- PRP$ cord-023134-y665agnh 1289 42 BWL BWL NNP cord-023134-y665agnh 1289 43 program program NN cord-023134-y665agnh 1289 44 ( ( -LRB- cord-023134-y665agnh 1289 45 overweight overweight NN cord-023134-y665agnh 1289 46 , , , cord-023134-y665agnh 1289 47 BCS BCS NNP cord-023134-y665agnh 1289 48 6 6 CD cord-023134-y665agnh 1289 49 - - HYPH cord-023134-y665agnh 1289 50 7/9 7/9 CD cord-023134-y665agnh 1289 51 ) ) -RRB- cord-023134-y665agnh 1289 52 and and CC cord-023134-y665agnh 1289 53 at at IN cord-023134-y665agnh 1289 54 the the DT cord-023134-y665agnh 1289 55 end end NN cord-023134-y665agnh 1289 56 of of IN cord-023134-y665agnh 1289 57 it -PRON- PRP cord-023134-y665agnh 1289 58 ( ( -LRB- cord-023134-y665agnh 1289 59 lean lean JJ cord-023134-y665agnh 1289 60 , , , cord-023134-y665agnh 1289 61 BCS BCS NNP cord-023134-y665agnh 1289 62 5/9 5/9 CD cord-023134-y665agnh 1289 63 ) ) -RRB- cord-023134-y665agnh 1289 64 . . . cord-023134-y665agnh 1290 1 For for IN cord-023134-y665agnh 1290 2 the the DT cord-023134-y665agnh 1290 3 6MWT 6mwt NN cord-023134-y665agnh 1290 4 , , , cord-023134-y665agnh 1290 5 dogs dog NNS cord-023134-y665agnh 1290 6 were be VBD cord-023134-y665agnh 1290 7 walked walk VBN cord-023134-y665agnh 1290 8 for for IN cord-023134-y665agnh 1290 9 6 6 CD cord-023134-y665agnh 1290 10 minutes minute NNS cord-023134-y665agnh 1290 11 , , , cord-023134-y665agnh 1290 12 along along IN cord-023134-y665agnh 1290 13 an an DT cord-023134-y665agnh 1290 14 inside inside JJ cord-023134-y665agnh 1290 15 53m 53m CD cord-023134-y665agnh 1290 16 - - HYPH cord-023134-y665agnh 1290 17 long long JJ cord-023134-y665agnh 1290 18 hallway hallway NN cord-023134-y665agnh 1290 19 . . . cord-023134-y665agnh 1291 1 Heart heart NN cord-023134-y665agnh 1291 2 rate rate NN cord-023134-y665agnh 1291 3 ( ( -LRB- cord-023134-y665agnh 1291 4 HR hr NN cord-023134-y665agnh 1291 5 ) ) -RRB- cord-023134-y665agnh 1291 6 and and CC cord-023134-y665agnh 1291 7 oxygen oxygen NN cord-023134-y665agnh 1291 8 saturation saturation NN cord-023134-y665agnh 1291 9 ( ( -LRB- cord-023134-y665agnh 1291 10 SpO2 SpO2 NNP cord-023134-y665agnh 1291 11 ) ) -RRB- cord-023134-y665agnh 1291 12 were be VBD cord-023134-y665agnh 1291 13 measured measure VBN cord-023134-y665agnh 1291 14 by by IN cord-023134-y665agnh 1291 15 pulse pulse NN cord-023134-y665agnh 1291 16 oximetry oximetry NN cord-023134-y665agnh 1291 17 before before IN cord-023134-y665agnh 1291 18 the the DT cord-023134-y665agnh 1291 19 test test NN cord-023134-y665agnh 1291 20 ( ( -LRB- cord-023134-y665agnh 1291 21 pre pre JJ cord-023134-y665agnh 1291 22 - - JJ cord-023134-y665agnh 1291 23 test test JJ cord-023134-y665agnh 1291 24 value value NN cord-023134-y665agnh 1291 25 ) ) -RRB- cord-023134-y665agnh 1291 26 , , , cord-023134-y665agnh 1291 27 after after IN cord-023134-y665agnh 1291 28 three three CD cord-023134-y665agnh 1291 29 minutes minute NNS cord-023134-y665agnh 1291 30 of of IN cord-023134-y665agnh 1291 31 walk walk NN cord-023134-y665agnh 1291 32 ( ( -LRB- cord-023134-y665agnh 1291 33 mid mid NN cord-023134-y665agnh 1291 34 - - JJ cord-023134-y665agnh 1291 35 test test JJ cord-023134-y665agnh 1291 36 value value NN cord-023134-y665agnh 1291 37 ) ) -RRB- cord-023134-y665agnh 1291 38 and and CC cord-023134-y665agnh 1291 39 at at IN cord-023134-y665agnh 1291 40 0 0 CD cord-023134-y665agnh 1291 41 , , , cord-023134-y665agnh 1291 42 1 1 CD cord-023134-y665agnh 1291 43 , , , cord-023134-y665agnh 1291 44 2 2 CD cord-023134-y665agnh 1291 45 , , , cord-023134-y665agnh 1291 46 3 3 CD cord-023134-y665agnh 1291 47 and and CC cord-023134-y665agnh 1291 48 5 5 CD cord-023134-y665agnh 1291 49 minutes minute NNS cord-023134-y665agnh 1291 50 post post NN cord-023134-y665agnh 1291 51 - - JJ cord-023134-y665agnh 1291 52 test test NN cord-023134-y665agnh 1291 53 . . . cord-023134-y665agnh 1292 1 All all DT cord-023134-y665agnh 1292 2 dogs dog NNS cord-023134-y665agnh 1292 3 concluded conclude VBD cord-023134-y665agnh 1292 4 the the DT cord-023134-y665agnh 1292 5 BWL BWL NNP cord-023134-y665agnh 1292 6 program program NN cord-023134-y665agnh 1292 7 ( ( -LRB- cord-023134-y665agnh 1292 8 initial initial JJ cord-023134-y665agnh 1292 9 BW BW NNP cord-023134-y665agnh 1292 10 : : : cord-023134-y665agnh 1292 11 27,3±2,9 27,3±2,9 CD cord-023134-y665agnh 1292 12 kg kg NNS cord-023134-y665agnh 1292 13 ; ; , cord-023134-y665agnh 1292 14 final final JJ cord-023134-y665agnh 1292 15 BW BW NNP cord-023134-y665agnh 1292 16 : : : cord-023134-y665agnh 1292 17 20,85±2,9 20,85±2,9 CD cord-023134-y665agnh 1292 18 , , , cord-023134-y665agnh 1292 19 means±SE means±SE NNP cord-023134-y665agnh 1292 20 , , , cord-023134-y665agnh 1292 21 P p NN cord-023134-y665agnh 1292 22 0,001 0,001 CD cord-023134-y665agnh 1292 23 ) ) -RRB- cord-023134-y665agnh 1292 24 . . . cord-023134-y665agnh 1293 1 BWL BWL NNP cord-023134-y665agnh 1293 2 caused cause VBD cord-023134-y665agnh 1293 3 a a DT cord-023134-y665agnh 1293 4 significant significant JJ cord-023134-y665agnh 1293 5 increase increase NN cord-023134-y665agnh 1293 6 in in IN cord-023134-y665agnh 1293 7 the the DT cord-023134-y665agnh 1293 8 walked walked JJ cord-023134-y665agnh 1293 9 distance distance NN cord-023134-y665agnh 1293 10 ( ( -LRB- cord-023134-y665agnh 1293 11 lean lean JJ cord-023134-y665agnh 1293 12 : : : cord-023134-y665agnh 1293 13 581,8±40,9 581,8±40,9 CD cord-023134-y665agnh 1293 14 m m NN cord-023134-y665agnh 1293 15 ; ; : cord-023134-y665agnh 1293 16 overweight overweight JJ cord-023134-y665agnh 1293 17 : : : cord-023134-y665agnh 1293 18 582,7±44,4 582,7±44,4 CD cord-023134-y665agnh 1293 19 m m NN cord-023134-y665agnh 1293 20 ; ; : cord-023134-y665agnh 1293 21 obese obese JJ cord-023134-y665agnh 1293 22 : : : cord-023134-y665agnh 1294 1 500,4±40,0 500,4±40,0 CD cord-023134-y665agnh 1294 2 m m NN cord-023134-y665agnh 1294 3 ; ; : cord-023134-y665agnh 1294 4 means±SE means±SE NNP cord-023134-y665agnh 1294 5 , , , cord-023134-y665agnh 1294 6 P p NN cord-023134-y665agnh 1294 7 0,05 0,05 NN cord-023134-y665agnh 1294 8 ) ) -RRB- cord-023134-y665agnh 1294 9 and and CC cord-023134-y665agnh 1294 10 a a DT cord-023134-y665agnh 1294 11 decrease decrease NN cord-023134-y665agnh 1294 12 in in IN cord-023134-y665agnh 1294 13 pretest pretest NN cord-023134-y665agnh 1294 14 respiratory respiratory JJ cord-023134-y665agnh 1294 15 rate rate NN cord-023134-y665agnh 1294 16 ( ( -LRB- cord-023134-y665agnh 1294 17 RR rr NN cord-023134-y665agnh 1294 18 ) ) -RRB- cord-023134-y665agnh 1295 1 ( ( -LRB- cord-023134-y665agnh 1295 2 lean lean JJ cord-023134-y665agnh 1295 3 : : : cord-023134-y665agnh 1295 4 33±3,3 33±3,3 CD cord-023134-y665agnh 1295 5 / / SYM cord-023134-y665agnh 1295 6 min min NN cord-023134-y665agnh 1295 7 ; ; : cord-023134-y665agnh 1296 1 overweight overweight JJ cord-023134-y665agnh 1296 2 : : : cord-023134-y665agnh 1296 3 40±3,6/ 40±3,6/ CD cord-023134-y665agnh 1296 4 min min NN cord-023134-y665agnh 1296 5 ; ; : cord-023134-y665agnh 1297 1 obese obese JJ cord-023134-y665agnh 1297 2 : : : cord-023134-y665agnh 1297 3 49±4,1 49±4,1 CD cord-023134-y665agnh 1297 4 / / SYM cord-023134-y665agnh 1297 5 min min NN cord-023134-y665agnh 1297 6 ; ; : cord-023134-y665agnh 1297 7 means±SE means±SE NNP cord-023134-y665agnh 1297 8 , , , cord-023134-y665agnh 1297 9 P p NN cord-023134-y665agnh 1297 10 0,05 0,05 NN cord-023134-y665agnh 1297 11 ) ) -RRB- cord-023134-y665agnh 1297 12 . . . cord-023134-y665agnh 1298 1 Resting rest VBG cord-023134-y665agnh 1298 2 arterial arterial JJ cord-023134-y665agnh 1298 3 blood blood NN cord-023134-y665agnh 1298 4 gas gas NN cord-023134-y665agnh 1298 5 results result NNS cord-023134-y665agnh 1298 6 were be VBD cord-023134-y665agnh 1298 7 not not RB cord-023134-y665agnh 1298 8 influenced influence VBN cord-023134-y665agnh 1298 9 by by IN cord-023134-y665agnh 1298 10 BWL BWL NNP cord-023134-y665agnh 1298 11 and and CC cord-023134-y665agnh 1298 12 neither neither DT cord-023134-y665agnh 1298 13 did do VBD cord-023134-y665agnh 1298 14 the the DT cord-023134-y665agnh 1298 15 pre pre JJ cord-023134-y665agnh 1298 16 - - JJ cord-023134-y665agnh 1298 17 test test JJ cord-023134-y665agnh 1298 18 HR hr NN cord-023134-y665agnh 1298 19 and and CC cord-023134-y665agnh 1298 20 SpO2 spo2 JJ cord-023134-y665agnh 1298 21 values value NNS cord-023134-y665agnh 1298 22 measured measure VBN cord-023134-y665agnh 1298 23 by by IN cord-023134-y665agnh 1298 24 pulse pulse NN cord-023134-y665agnh 1298 25 oximetry oximetry NN cord-023134-y665agnh 1298 26 . . . cord-023134-y665agnh 1299 1 Obese obese JJ cord-023134-y665agnh 1299 2 dogs dog NNS cord-023134-y665agnh 1299 3 showed show VBD cord-023134-y665agnh 1299 4 significant significant JJ cord-023134-y665agnh 1299 5 higher high JJR cord-023134-y665agnh 1299 6 HR hr NN cord-023134-y665agnh 1299 7 mid mid NN cord-023134-y665agnh 1299 8 - - JJ cord-023134-y665agnh 1299 9 test test JJ cord-023134-y665agnh 1299 10 values value NNS cord-023134-y665agnh 1299 11 compared compare VBN cord-023134-y665agnh 1299 12 to to IN cord-023134-y665agnh 1299 13 overweight overweight JJ cord-023134-y665agnh 1299 14 and and CC cord-023134-y665agnh 1299 15 lean lean JJ cord-023134-y665agnh 1299 16 dogs dog NNS cord-023134-y665agnh 1299 17 ( ( -LRB- cord-023134-y665agnh 1299 18 lean lean JJ cord-023134-y665agnh 1299 19 : : : cord-023134-y665agnh 1299 20 122,0±7,5 122,0±7,5 CD cord-023134-y665agnh 1299 21 / / SYM cord-023134-y665agnh 1299 22 min min NN cord-023134-y665agnh 1299 23 ; ; : cord-023134-y665agnh 1299 24 overweight overweight NN cord-023134-y665agnh 1299 25 : : : cord-023134-y665agnh 1299 26 119,8±7,2 119,8±7,2 CD cord-023134-y665agnh 1299 27 / / SYM cord-023134-y665agnh 1299 28 min min NN cord-023134-y665agnh 1299 29 ; ; : cord-023134-y665agnh 1299 30 obese obese JJ cord-023134-y665agnh 1299 31 : : : cord-023134-y665agnh 1299 32 167,2±8,2 167,2±8,2 CD cord-023134-y665agnh 1299 33 / / SYM cord-023134-y665agnh 1299 34 min min NN cord-023134-y665agnh 1299 35 ; ; : cord-023134-y665agnh 1299 36 means±SE means±SE NNP cord-023134-y665agnh 1299 37 , , , cord-023134-y665agnh 1299 38 P p NN cord-023134-y665agnh 1299 39 0,001 0,001 CD cord-023134-y665agnh 1299 40 ) ) -RRB- cord-023134-y665agnh 1299 41 . . . cord-023134-y665agnh 1300 1 Moreover moreover RB cord-023134-y665agnh 1300 2 , , , cord-023134-y665agnh 1300 3 SpO2 spo2 JJ cord-023134-y665agnh 1300 4 values value NNS cord-023134-y665agnh 1300 5 recorded record VBD cord-023134-y665agnh 1300 6 at at IN cord-023134-y665agnh 1300 7 0 0 CD cord-023134-y665agnh 1300 8 and and CC cord-023134-y665agnh 1300 9 1 1 CD cord-023134-y665agnh 1300 10 minute minute NN cord-023134-y665agnh 1300 11 post post NN cord-023134-y665agnh 1300 12 - - JJ cord-023134-y665agnh 1300 13 test test NN cord-023134-y665agnh 1300 14 were be VBD cord-023134-y665agnh 1300 15 significantly significantly RB cord-023134-y665agnh 1300 16 higher high JJR cord-023134-y665agnh 1300 17 in in IN cord-023134-y665agnh 1300 18 overweight overweight JJ cord-023134-y665agnh 1300 19 and and CC cord-023134-y665agnh 1300 20 lean lean JJ cord-023134-y665agnh 1300 21 dogs dog NNS cord-023134-y665agnh 1300 22 , , , cord-023134-y665agnh 1300 23 compared compare VBN cord-023134-y665agnh 1300 24 to to IN cord-023134-y665agnh 1300 25 obese obese JJ cord-023134-y665agnh 1300 26 dogs dog NNS cord-023134-y665agnh 1300 27 . . . cord-023134-y665agnh 1301 1 Also also RB cord-023134-y665agnh 1301 2 , , , cord-023134-y665agnh 1301 3 HR hr NN cord-023134-y665agnh 1301 4 values value NNS cord-023134-y665agnh 1301 5 registered register VBN cord-023134-y665agnh 1301 6 at at IN cord-023134-y665agnh 1301 7 1 1 CD cord-023134-y665agnh 1301 8 , , , cord-023134-y665agnh 1301 9 2 2 CD cord-023134-y665agnh 1301 10 , , , cord-023134-y665agnh 1301 11 3 3 CD cord-023134-y665agnh 1301 12 and and CC cord-023134-y665agnh 1301 13 5 5 CD cord-023134-y665agnh 1301 14 minutes minute NNS cord-023134-y665agnh 1301 15 post post NN cord-023134-y665agnh 1301 16 - - JJ cord-023134-y665agnh 1301 17 test test NN cord-023134-y665agnh 1301 18 were be VBD cord-023134-y665agnh 1301 19 all all DT cord-023134-y665agnh 1301 20 lower low JJR cord-023134-y665agnh 1301 21 in in IN cord-023134-y665agnh 1301 22 overweight overweight JJ cord-023134-y665agnh 1301 23 and and CC cord-023134-y665agnh 1301 24 lean lean JJ cord-023134-y665agnh 1301 25 dogs dog NNS cord-023134-y665agnh 1301 26 . . . cord-023134-y665agnh 1302 1 In in IN cord-023134-y665agnh 1302 2 conclusion conclusion NN cord-023134-y665agnh 1302 3 , , , cord-023134-y665agnh 1302 4 obesity obesity NN cord-023134-y665agnh 1302 5 negatively negatively RB cord-023134-y665agnh 1302 6 affects affect VBZ cord-023134-y665agnh 1302 7 the the DT cord-023134-y665agnh 1302 8 blood blood NN cord-023134-y665agnh 1302 9 oxygenation oxygenation NN cord-023134-y665agnh 1302 10 level level NN cord-023134-y665agnh 1302 11 during during IN cord-023134-y665agnh 1302 12 and and CC cord-023134-y665agnh 1302 13 shortly shortly RB cord-023134-y665agnh 1302 14 after after IN cord-023134-y665agnh 1302 15 physical physical JJ cord-023134-y665agnh 1302 16 exercise exercise NN cord-023134-y665agnh 1302 17 in in IN cord-023134-y665agnh 1302 18 dogs dog NNS cord-023134-y665agnh 1302 19 , , , cord-023134-y665agnh 1302 20 with with IN cord-023134-y665agnh 1302 21 subsequent subsequent JJ cord-023134-y665agnh 1302 22 HR hr NN cord-023134-y665agnh 1302 23 increase increase NN cord-023134-y665agnh 1302 24 . . . cord-023134-y665agnh 1303 1 BWL BWL NNP cord-023134-y665agnh 1303 2 induces induce VBZ cord-023134-y665agnh 1303 3 a a DT cord-023134-y665agnh 1303 4 significant significant JJ cord-023134-y665agnh 1303 5 decrease decrease NN cord-023134-y665agnh 1303 6 in in IN cord-023134-y665agnh 1303 7 resting rest VBG cord-023134-y665agnh 1303 8 RR rr NN cord-023134-y665agnh 1303 9 and and CC cord-023134-y665agnh 1303 10 it -PRON- PRP cord-023134-y665agnh 1303 11 improves improve VBZ cord-023134-y665agnh 1303 12 pulmonary pulmonary JJ cord-023134-y665agnh 1303 13 function function NN cord-023134-y665agnh 1303 14 during during IN cord-023134-y665agnh 1303 15 exercise exercise NN cord-023134-y665agnh 1303 16 , , , cord-023134-y665agnh 1303 17 even even RB cord-023134-y665agnh 1303 18 before before IN cord-023134-y665agnh 1303 19 achieving achieve VBG cord-023134-y665agnh 1303 20 the the DT cord-023134-y665agnh 1303 21 targeted target VBN cord-023134-y665agnh 1303 22 ideal ideal JJ cord-023134-y665agnh 1303 23 BW BW NNP cord-023134-y665agnh 1303 24 . . . cord-023134-y665agnh 1304 1 The the DT cord-023134-y665agnh 1304 2 6MWT 6mwt NN cord-023134-y665agnh 1304 3 , , , cord-023134-y665agnh 1304 4 but but CC cord-023134-y665agnh 1304 5 not not RB cord-023134-y665agnh 1304 6 pre pre VB cord-023134-y665agnh 1304 7 - - VB cord-023134-y665agnh 1304 8 test test VB cord-023134-y665agnh 1304 9 arterial arterial JJ cord-023134-y665agnh 1304 10 blood blood NN cord-023134-y665agnh 1304 11 gas gas NN cord-023134-y665agnh 1304 12 values value NNS cord-023134-y665agnh 1304 13 , , , cord-023134-y665agnh 1304 14 is be VBZ cord-023134-y665agnh 1304 15 an an DT cord-023134-y665agnh 1304 16 efficient efficient JJ cord-023134-y665agnh 1304 17 tool tool NN cord-023134-y665agnh 1304 18 to to TO cord-023134-y665agnh 1304 19 demonstrate demonstrate VB cord-023134-y665agnh 1304 20 the the DT cord-023134-y665agnh 1304 21 efficacy efficacy NN cord-023134-y665agnh 1304 22 of of IN cord-023134-y665agnh 1304 23 BWL BWL NNP cord-023134-y665agnh 1304 24 . . . cord-023134-y665agnh 1305 1 There there EX cord-023134-y665agnh 1305 2 are be VBP cord-023134-y665agnh 1305 3 few few JJ cord-023134-y665agnh 1305 4 diagnostic diagnostic JJ cord-023134-y665agnh 1305 5 laboratory laboratory NN cord-023134-y665agnh 1305 6 methods method NNS cord-023134-y665agnh 1305 7 available available JJ cord-023134-y665agnh 1305 8 for for IN cord-023134-y665agnh 1305 9 evaluation evaluation NN cord-023134-y665agnh 1305 10 of of IN cord-023134-y665agnh 1305 11 platelet platelet NN cord-023134-y665agnh 1305 12 function function NN cord-023134-y665agnh 1305 13 and and CC cord-023134-y665agnh 1305 14 contribution contribution NN cord-023134-y665agnh 1305 15 to to IN cord-023134-y665agnh 1305 16 thrombotic thrombotic JJ cord-023134-y665agnh 1305 17 events event NNS cord-023134-y665agnh 1305 18 in in IN cord-023134-y665agnh 1305 19 the the DT cord-023134-y665agnh 1305 20 clinical clinical JJ cord-023134-y665agnh 1305 21 setting setting NN cord-023134-y665agnh 1305 22 . . . cord-023134-y665agnh 1306 1 The the DT cord-023134-y665agnh 1306 2 impedance impedance NN cord-023134-y665agnh 1306 3 whole whole JJ cord-023134-y665agnh 1306 4 blood blood NN cord-023134-y665agnh 1306 5 platelet platelet NN cord-023134-y665agnh 1306 6 aggregometer aggregometer NN cord-023134-y665agnh 1306 7 Multiplate Multiplate NNP cord-023134-y665agnh 1306 8 ® ® VBP cord-023134-y665agnh 1306 9 has have VBZ cord-023134-y665agnh 1306 10 recently recently RB cord-023134-y665agnh 1306 11 become become VBN cord-023134-y665agnh 1306 12 available available JJ cord-023134-y665agnh 1306 13 . . . cord-023134-y665agnh 1307 1 Although although IN cord-023134-y665agnh 1307 2 it -PRON- PRP cord-023134-y665agnh 1307 3 is be VBZ cord-023134-y665agnh 1307 4 being be VBG cord-023134-y665agnh 1307 5 marketed market VBN cord-023134-y665agnh 1307 6 for for IN cord-023134-y665agnh 1307 7 monitoring monitor VBG cord-023134-y665agnh 1307 8 effect effect NN cord-023134-y665agnh 1307 9 of of IN cord-023134-y665agnh 1307 10 antiplatelet antiplatelet NN cord-023134-y665agnh 1307 11 therapy therapy NN cord-023134-y665agnh 1307 12 , , , cord-023134-y665agnh 1307 13 it -PRON- PRP cord-023134-y665agnh 1307 14 can can MD cord-023134-y665agnh 1307 15 also also RB cord-023134-y665agnh 1307 16 be be VB cord-023134-y665agnh 1307 17 used use VBN cord-023134-y665agnh 1307 18 for for IN cord-023134-y665agnh 1307 19 assessment assessment NN cord-023134-y665agnh 1307 20 of of IN cord-023134-y665agnh 1307 21 platelet platelet NN cord-023134-y665agnh 1307 22 aggregation aggregation NN cord-023134-y665agnh 1307 23 in in IN cord-023134-y665agnh 1307 24 response response NN cord-023134-y665agnh 1307 25 to to IN cord-023134-y665agnh 1307 26 various various JJ cord-023134-y665agnh 1307 27 agonists agonist NNS cord-023134-y665agnh 1307 28 , , , cord-023134-y665agnh 1307 29 reflecting reflect VBG cord-023134-y665agnh 1307 30 platelet platelet NN cord-023134-y665agnh 1307 31 function function NN cord-023134-y665agnh 1307 32 , , , cord-023134-y665agnh 1307 33 activity activity NN cord-023134-y665agnh 1307 34 and and CC cord-023134-y665agnh 1307 35 reactivity reactivity NN cord-023134-y665agnh 1307 36 in in IN cord-023134-y665agnh 1307 37 response response NN cord-023134-y665agnh 1307 38 to to IN cord-023134-y665agnh 1307 39 disease disease NN cord-023134-y665agnh 1307 40 . . . cord-023134-y665agnh 1308 1 The the DT cord-023134-y665agnh 1308 2 purpose purpose NN cord-023134-y665agnh 1308 3 of of IN cord-023134-y665agnh 1308 4 this this DT cord-023134-y665agnh 1308 5 study study NN cord-023134-y665agnh 1308 6 was be VBD cord-023134-y665agnh 1308 7 therefore therefore RB cord-023134-y665agnh 1308 8 to to TO cord-023134-y665agnh 1308 9 investigate investigate VB cord-023134-y665agnh 1308 10 Multiplate Multiplate NNP cord-023134-y665agnh 1308 11 ® ® . cord-023134-y665agnh 1308 12 as as IN cord-023134-y665agnh 1308 13 a a DT cord-023134-y665agnh 1308 14 diagnostic diagnostic JJ cord-023134-y665agnh 1308 15 tool tool NN cord-023134-y665agnh 1308 16 for for IN cord-023134-y665agnh 1308 17 detection detection NN cord-023134-y665agnh 1308 18 of of IN cord-023134-y665agnh 1308 19 variations variation NNS cord-023134-y665agnh 1308 20 in in IN cord-023134-y665agnh 1308 21 platelet platelet NN cord-023134-y665agnh 1308 22 aggregation aggregation NN cord-023134-y665agnh 1308 23 in in IN cord-023134-y665agnh 1308 24 dogs dog NNS cord-023134-y665agnh 1308 25 with with IN cord-023134-y665agnh 1308 26 diseases disease NNS cord-023134-y665agnh 1308 27 known know VBN cord-023134-y665agnh 1308 28 to to TO cord-023134-y665agnh 1308 29 predispose predispose VB cord-023134-y665agnh 1308 30 to to IN cord-023134-y665agnh 1308 31 hypercoagulability hypercoagulability NN cord-023134-y665agnh 1308 32 and and CC cord-023134-y665agnh 1308 33 thrombosis thrombosis NN cord-023134-y665agnh 1308 34 and and CC cord-023134-y665agnh 1308 35 to to TO cord-023134-y665agnh 1308 36 evaluate evaluate VB cord-023134-y665agnh 1308 37 whether whether IN cord-023134-y665agnh 1308 38 there there EX cord-023134-y665agnh 1308 39 is be VBZ cord-023134-y665agnh 1308 40 a a DT cord-023134-y665agnh 1308 41 correlation correlation NN cord-023134-y665agnh 1308 42 between between IN cord-023134-y665agnh 1308 43 Multiplate Multiplate NNP cord-023134-y665agnh 1308 44 aggregation aggregation NN cord-023134-y665agnh 1308 45 response response NN cord-023134-y665agnh 1308 46 and and CC cord-023134-y665agnh 1308 47 the the DT cord-023134-y665agnh 1308 48 maximal maximal JJ cord-023134-y665agnh 1308 49 amplitude amplitude NN cord-023134-y665agnh 1308 50 ( ( -LRB- cord-023134-y665agnh 1308 51 MA MA NNP cord-023134-y665agnh 1308 52 ) ) -RRB- cord-023134-y665agnh 1308 53 measured measure VBN cord-023134-y665agnh 1308 54 by by IN cord-023134-y665agnh 1308 55 thromboelastography thromboelastography NNP cord-023134-y665agnh 1308 56 ( ( -LRB- cord-023134-y665agnh 1308 57 TEG).Twenty TEG).Twenty NNP cord-023134-y665agnh 1308 58 clinically clinically RB cord-023134-y665agnh 1308 59 healthy healthy JJ cord-023134-y665agnh 1308 60 dogs dog NNS cord-023134-y665agnh 1308 61 and and CC cord-023134-y665agnh 1308 62 eighteen eighteen CD cord-023134-y665agnh 1308 63 diseased diseased JJ cord-023134-y665agnh 1308 64 dogs dog NNS cord-023134-y665agnh 1308 65 with with IN cord-023134-y665agnh 1308 66 neoplasia neoplasia NN cord-023134-y665agnh 1308 67 , , , cord-023134-y665agnh 1308 68 generalized generalized JJ cord-023134-y665agnh 1308 69 inflammation inflammation NN cord-023134-y665agnh 1308 70 or or CC cord-023134-y665agnh 1308 71 protein protein NN cord-023134-y665agnh 1308 72 losing lose VBG cord-023134-y665agnh 1308 73 enteropathy enteropathy NNP cord-023134-y665agnh 1309 1 ornephropathy ornephropathy NNP cord-023134-y665agnh 1309 2 admitted admit VBD cord-023134-y665agnh 1309 3 to to IN cord-023134-y665agnh 1309 4 the the DT cord-023134-y665agnh 1309 5 University University NNP cord-023134-y665agnh 1309 6 Hospital Hospital NNP cord-023134-y665agnh 1309 7 for for IN cord-023134-y665agnh 1309 8 Companion Companion NNP cord-023134-y665agnh 1309 9 Animals Animals NNPS cord-023134-y665agnh 1309 10 , , , cord-023134-y665agnh 1309 11 University University NNP cord-023134-y665agnh 1309 12 of of IN cord-023134-y665agnh 1309 13 Copenhagen Copenhagen NNP cord-023134-y665agnh 1309 14 , , , cord-023134-y665agnh 1309 15 were be VBD cord-023134-y665agnh 1309 16 included include VBN cord-023134-y665agnh 1309 17 in in IN cord-023134-y665agnh 1309 18 the the DT cord-023134-y665agnh 1309 19 study study NN cord-023134-y665agnh 1309 20 . . . cord-023134-y665agnh 1310 1 Citrated Citrated NNP cord-023134-y665agnh 1310 2 and and CC cord-023134-y665agnh 1310 3 heparinised heparinise VBD cord-023134-y665agnh 1310 4 blood blood NN cord-023134-y665agnh 1310 5 samples sample NNS cord-023134-y665agnh 1310 6 were be VBD cord-023134-y665agnh 1310 7 collected collect VBN cord-023134-y665agnh 1310 8 . . . cord-023134-y665agnh 1311 1 Multiplate Multiplate NNP cord-023134-y665agnh 1311 2 ® ® VBP cord-023134-y665agnh 1311 3 aggregations aggregation NNS cord-023134-y665agnh 1311 4 were be VBD cord-023134-y665agnh 1311 5 performed perform VBN cord-023134-y665agnh 1311 6 on on IN cord-023134-y665agnh 1311 7 diluted diluted JJ cord-023134-y665agnh 1311 8 heparinised heparinised JJ cord-023134-y665agnh 1311 9 whole whole JJ cord-023134-y665agnh 1311 10 blood blood NN cord-023134-y665agnh 1311 11 for for IN cord-023134-y665agnh 1311 12 12 12 CD cord-023134-y665agnh 1311 13 minutes minute NNS cord-023134-y665agnh 1311 14 using use VBG cord-023134-y665agnh 1311 15 ADP ADP NNP cord-023134-y665agnh 1311 16 , , , cord-023134-y665agnh 1311 17 Collagen Collagen NNP cord-023134-y665agnh 1311 18 ( ( -LRB- cord-023134-y665agnh 1311 19 COL COL NNP cord-023134-y665agnh 1311 20 ) ) -RRB- cord-023134-y665agnh 1311 21 and and CC cord-023134-y665agnh 1311 22 Arachidonic arachidonic JJ cord-023134-y665agnh 1311 23 Acid acid NN cord-023134-y665agnh 1311 24 ( ( -LRB- cord-023134-y665agnh 1311 25 AA AA NNP cord-023134-y665agnh 1311 26 ) ) -RRB- cord-023134-y665agnh 1311 27 as as IN cord-023134-y665agnh 1311 28 agonists agonist NNS cord-023134-y665agnh 1311 29 and and CC cord-023134-y665agnh 1311 30 NaCl nacl NN cord-023134-y665agnh 1311 31 as as IN cord-023134-y665agnh 1311 32 buffer buffer NN cord-023134-y665agnh 1311 33 control control NN cord-023134-y665agnh 1311 34 . . . cord-023134-y665agnh 1312 1 Results result NNS cord-023134-y665agnh 1312 2 were be VBD cord-023134-y665agnh 1312 3 recorded record VBN cord-023134-y665agnh 1312 4 as as IN cord-023134-y665agnh 1312 5 area area NN cord-023134-y665agnh 1312 6 under under IN cord-023134-y665agnh 1312 7 the the DT cord-023134-y665agnh 1312 8 curve curve NN cord-023134-y665agnh 1312 9 ( ( -LRB- cord-023134-y665agnh 1312 10 AUC AUC NNP cord-023134-y665agnh 1312 11 ) ) -RRB- cord-023134-y665agnh 1312 12 . . . cord-023134-y665agnh 1313 1 Dilute dilute VB cord-023134-y665agnh 1313 2 ( ( -LRB- cord-023134-y665agnh 1313 3 1:50000 1:50000 CD cord-023134-y665agnh 1313 4 ) ) -RRB- cord-023134-y665agnh 1314 1 Tissue tissue NN cord-023134-y665agnh 1314 2 Factor Factor NNP cord-023134-y665agnh 1314 3 TEG TEG NNP cord-023134-y665agnh 1314 4 analyses analysis NNS cord-023134-y665agnh 1314 5 were be VBD cord-023134-y665agnh 1314 6 performed perform VBN cord-023134-y665agnh 1314 7 on on IN cord-023134-y665agnh 1314 8 citrated citrate VBN cord-023134-y665agnh 1314 9 whole whole JJ cord-023134-y665agnh 1314 10 blood blood NN cord-023134-y665agnh 1314 11 . . . cord-023134-y665agnh 1315 1 Diseased diseased JJ cord-023134-y665agnh 1315 2 dogs dog NNS cord-023134-y665agnh 1315 3 had have VBD cord-023134-y665agnh 1315 4 significantly significantly RB cord-023134-y665agnh 1315 5 increased increase VBN cord-023134-y665agnh 1315 6 AUC AUC NNP cord-023134-y665agnh 1315 7 compared compare VBN cord-023134-y665agnh 1315 8 to to IN cord-023134-y665agnh 1315 9 healthy healthy JJ cord-023134-y665agnh 1315 10 dogs dog NNS cord-023134-y665agnh 1315 11 for for IN cord-023134-y665agnh 1315 12 NaCl nacl NN cord-023134-y665agnh 1315 13 buffer buffer NN cord-023134-y665agnh 1315 14 control control NN cord-023134-y665agnh 1315 15 ( ( -LRB- cord-023134-y665agnh 1315 16 p=0.0005 p=0.0005 NNP cord-023134-y665agnh 1315 17 ) ) -RRB- cord-023134-y665agnh 1315 18 , , , cord-023134-y665agnh 1315 19 ADP ADP NNP cord-023134-y665agnh 1315 20 ( ( -LRB- cord-023134-y665agnh 1315 21 p<0.0001 p<0.0001 NNP cord-023134-y665agnh 1315 22 ) ) -RRB- cord-023134-y665agnh 1315 23 and and CC cord-023134-y665agnh 1315 24 COL COL NNP cord-023134-y665agnh 1315 25 ( ( -LRB- cord-023134-y665agnh 1315 26 p=0.0048 p=0.0048 NNP cord-023134-y665agnh 1315 27 ) ) -RRB- cord-023134-y665agnh 1315 28 whereas whereas IN cord-023134-y665agnh 1315 29 no no DT cord-023134-y665agnh 1315 30 significant significant JJ cord-023134-y665agnh 1315 31 difference difference NN cord-023134-y665agnh 1315 32 was be VBD cord-023134-y665agnh 1315 33 obtained obtain VBN cord-023134-y665agnh 1315 34 for for IN cord-023134-y665agnh 1315 35 AA AA NNP cord-023134-y665agnh 1315 36 as as IN cord-023134-y665agnh 1315 37 agonist agonist NN cord-023134-y665agnh 1315 38 ( ( -LRB- cord-023134-y665agnh 1315 39 p=0.3116 p=0.3116 NNP cord-023134-y665agnh 1315 40 ) ) -RRB- cord-023134-y665agnh 1315 41 . . . cord-023134-y665agnh 1316 1 TEG TEG NNP cord-023134-y665agnh 1316 2 - - HYPH cord-023134-y665agnh 1316 3 MA MA NNP cord-023134-y665agnh 1316 4 was be VBD cord-023134-y665agnh 1316 5 significantly significantly RB cord-023134-y665agnh 1316 6 higher high JJR cord-023134-y665agnh 1316 7 ( ( -LRB- cord-023134-y665agnh 1316 8 p=0.0114 p=0.0114 NNS cord-023134-y665agnh 1316 9 ) ) -RRB- cord-023134-y665agnh 1316 10 in in IN cord-023134-y665agnh 1316 11 diseased diseased JJ cord-023134-y665agnh 1316 12 dogs dog NNS cord-023134-y665agnh 1316 13 compared compare VBN cord-023134-y665agnh 1316 14 to to IN cord-023134-y665agnh 1316 15 healthy healthy JJ cord-023134-y665agnh 1316 16 dogs dog NNS cord-023134-y665agnh 1316 17 . . . cord-023134-y665agnh 1317 1 A a DT cord-023134-y665agnh 1317 2 significant significant JJ cord-023134-y665agnh 1317 3 correlation correlation NN cord-023134-y665agnh 1317 4 was be VBD cord-023134-y665agnh 1317 5 not not RB cord-023134-y665agnh 1317 6 found find VBN cord-023134-y665agnh 1317 7 between between IN cord-023134-y665agnh 1317 8 TEG TEG NNP cord-023134-y665agnh 1317 9 - - HYPH cord-023134-y665agnh 1317 10 MA MA NNP cord-023134-y665agnh 1317 11 and and CC cord-023134-y665agnh 1317 12 Multiplate Multiplate NNP cord-023134-y665agnh 1317 13 AUC AUC NNP cord-023134-y665agnh 1317 14 using use VBG cord-023134-y665agnh 1317 15 ADP ADP NNP cord-023134-y665agnh 1317 16 ( ( -LRB- cord-023134-y665agnh 1317 17 p=0.1720 p=0.1720 NN cord-023134-y665agnh 1317 18 , , , cord-023134-y665agnh 1317 19 r=-0.3366 r=-0.3366 NNP cord-023134-y665agnh 1317 20 ) ) -RRB- cord-023134-y665agnh 1317 21 , , , cord-023134-y665agnh 1317 22 COL COL NNP cord-023134-y665agnh 1317 23 ( ( -LRB- cord-023134-y665agnh 1317 24 p=0.2274 p=0.2274 NNP cord-023134-y665agnh 1317 25 , , , cord-023134-y665agnh 1317 26 r=-0.2994 r=-0.2994 NNP cord-023134-y665agnh 1317 27 ) ) -RRB- cord-023134-y665agnh 1317 28 or or CC cord-023134-y665agnh 1317 29 AA AA NNP cord-023134-y665agnh 1317 30 ( ( -LRB- cord-023134-y665agnh 1317 31 p=0.4304 p=0.4304 NN cord-023134-y665agnh 1317 32 , , , cord-023134-y665agnh 1317 33 r=-0.1982 r=-0.1982 NNP cord-023134-y665agnh 1317 34 ) ) -RRB- cord-023134-y665agnh 1318 1 .These .These . cord-023134-y665agnh 1319 1 results result NNS cord-023134-y665agnh 1319 2 demonstrate demonstrate VBP cord-023134-y665agnh 1319 3 that that IN cord-023134-y665agnh 1319 4 Multiplate Multiplate NNP cord-023134-y665agnh 1319 5 ® ® POS cord-023134-y665agnh 1319 6 aggregation aggregation NN cord-023134-y665agnh 1319 7 responses response NNS cord-023134-y665agnh 1319 8 are be VBP cord-023134-y665agnh 1319 9 significantly significantly RB cord-023134-y665agnh 1319 10 increased increase VBN cord-023134-y665agnh 1319 11 in in IN cord-023134-y665agnh 1319 12 a a DT cord-023134-y665agnh 1319 13 population population NN cord-023134-y665agnh 1319 14 of of IN cord-023134-y665agnh 1319 15 diseased diseased JJ cord-023134-y665agnh 1319 16 dogs dog NNS cord-023134-y665agnh 1319 17 with with IN cord-023134-y665agnh 1319 18 diseases disease NNS cord-023134-y665agnh 1319 19 known know VBN cord-023134-y665agnh 1319 20 to to TO cord-023134-y665agnh 1319 21 predispose predispose VB cord-023134-y665agnh 1319 22 to to IN cord-023134-y665agnh 1319 23 hypercoagulability hypercoagulability NN cord-023134-y665agnh 1319 24 and and CC cord-023134-y665agnh 1319 25 thrombosis thrombosis NN cord-023134-y665agnh 1319 26 , , , cord-023134-y665agnh 1319 27 but but CC cord-023134-y665agnh 1319 28 results result NNS cord-023134-y665agnh 1319 29 are be VBP cord-023134-y665agnh 1319 30 not not RB cord-023134-y665agnh 1319 31 significantly significantly RB cord-023134-y665agnh 1319 32 correlated correlate VBN cord-023134-y665agnh 1319 33 to to IN cord-023134-y665agnh 1319 34 TEG TEG NNP cord-023134-y665agnh 1319 35 - - HYPH cord-023134-y665agnh 1319 36 MA MA NNP cord-023134-y665agnh 1319 37 . . . cord-023134-y665agnh 1320 1 This this DT cord-023134-y665agnh 1320 2 suggests suggest VBZ cord-023134-y665agnh 1320 3 that that IN cord-023134-y665agnh 1320 4 the the DT cord-023134-y665agnh 1320 5 Multiplate Multiplate NNP cord-023134-y665agnh 1320 6 method method NN cord-023134-y665agnh 1320 7 can can MD cord-023134-y665agnh 1320 8 be be VB cord-023134-y665agnh 1320 9 used use VBN cord-023134-y665agnh 1320 10 to to TO cord-023134-y665agnh 1320 11 detect detect VB cord-023134-y665agnh 1320 12 increased increase VBN cord-023134-y665agnh 1320 13 platelet platelet NN cord-023134-y665agnh 1320 14 reactivity reactivity NN cord-023134-y665agnh 1320 15 in in IN cord-023134-y665agnh 1320 16 dogs dog NNS cord-023134-y665agnh 1320 17 with with IN cord-023134-y665agnh 1320 18 diseases disease NNS cord-023134-y665agnh 1320 19 known know VBN cord-023134-y665agnh 1320 20 to to TO cord-023134-y665agnh 1320 21 predispose predispose VB cord-023134-y665agnh 1320 22 for for IN cord-023134-y665agnh 1320 23 hypercoagulability hypercoagulability NN cord-023134-y665agnh 1320 24 and and CC cord-023134-y665agnh 1320 25 thrombosis thrombosis NN cord-023134-y665agnh 1320 26 and and CC cord-023134-y665agnh 1320 27 that that IN cord-023134-y665agnh 1320 28 Multiplate Multiplate NNP cord-023134-y665agnh 1320 29 provides provide VBZ cord-023134-y665agnh 1320 30 additional additional JJ cord-023134-y665agnh 1320 31 information information NN cord-023134-y665agnh 1320 32 on on IN cord-023134-y665agnh 1320 33 platelet platelet NN cord-023134-y665agnh 1320 34 function function NN cord-023134-y665agnh 1320 35 than than IN cord-023134-y665agnh 1320 36 TEG TEG NNP cord-023134-y665agnh 1320 37 alone alone RB cord-023134-y665agnh 1320 38 in in IN cord-023134-y665agnh 1320 39 this this DT cord-023134-y665agnh 1320 40 patient patient NN cord-023134-y665agnh 1320 41 group group NN cord-023134-y665agnh 1320 42 . . . cord-023134-y665agnh 1321 1 Further further JJ cord-023134-y665agnh 1321 2 studies study NNS cord-023134-y665agnh 1321 3 are be VBP cord-023134-y665agnh 1321 4 needed need VBN cord-023134-y665agnh 1321 5 to to TO cord-023134-y665agnh 1321 6 determine determine VB cord-023134-y665agnh 1321 7 how how WRB cord-023134-y665agnh 1321 8 Multiplate Multiplate NNP cord-023134-y665agnh 1321 9 and and CC cord-023134-y665agnh 1321 10 TEG TEG NNP cord-023134-y665agnh 1321 11 - - HYPH cord-023134-y665agnh 1321 12 MA MA NNP cord-023134-y665agnh 1321 13 results result NNS cord-023134-y665agnh 1321 14 correlate correlate VBP cord-023134-y665agnh 1321 15 to to IN cord-023134-y665agnh 1321 16 thrombosis thrombosis NN cord-023134-y665agnh 1321 17 and and CC cord-023134-y665agnh 1321 18 whether whether IN cord-023134-y665agnh 1321 19 there there EX cord-023134-y665agnh 1321 20 may may MD cord-023134-y665agnh 1321 21 be be VB cord-023134-y665agnh 1321 22 an an DT cord-023134-y665agnh 1321 23 added add VBN cord-023134-y665agnh 1321 24 benefit benefit NN cord-023134-y665agnh 1321 25 of of IN cord-023134-y665agnh 1321 26 using use VBG cord-023134-y665agnh 1321 27 them -PRON- PRP cord-023134-y665agnh 1321 28 in in IN cord-023134-y665agnh 1321 29 combination combination NN cord-023134-y665agnh 1321 30 . . . cord-023134-y665agnh 1322 1 Hypoalbuminaemia Hypoalbuminaemia NNP cord-023134-y665agnh 1322 2 is be VBZ cord-023134-y665agnh 1322 3 a a DT cord-023134-y665agnh 1322 4 commonly commonly RB cord-023134-y665agnh 1322 5 identified identify VBN cord-023134-y665agnh 1322 6 biochemical biochemical JJ cord-023134-y665agnh 1322 7 dyscrasia dyscrasia NNS cord-023134-y665agnh 1322 8 . . . cord-023134-y665agnh 1323 1 The the DT cord-023134-y665agnh 1323 2 clinical clinical JJ cord-023134-y665agnh 1323 3 impact impact NN cord-023134-y665agnh 1323 4 of of IN cord-023134-y665agnh 1323 5 this this DT cord-023134-y665agnh 1323 6 can can MD cord-023134-y665agnh 1323 7 be be VB cord-023134-y665agnh 1323 8 far far RB cord-023134-y665agnh 1323 9 reaching reach VBG cord-023134-y665agnh 1323 10 , , , cord-023134-y665agnh 1323 11 particularly particularly RB cord-023134-y665agnh 1323 12 in in IN cord-023134-y665agnh 1323 13 severely severely RB cord-023134-y665agnh 1323 14 affected affect VBN cord-023134-y665agnh 1323 15 animals animal NNS cord-023134-y665agnh 1323 16 . . . cord-023134-y665agnh 1324 1 Problems problem NNS cord-023134-y665agnh 1324 2 recognised recognise VBN cord-023134-y665agnh 1324 3 to to TO cord-023134-y665agnh 1324 4 ensue ensue VB cord-023134-y665agnh 1324 5 include include VBP cord-023134-y665agnh 1324 6 altered alter VBN cord-023134-y665agnh 1324 7 colloid colloid NN cord-023134-y665agnh 1324 8 osmotic osmotic JJ cord-023134-y665agnh 1324 9 pressure pressure NN cord-023134-y665agnh 1324 10 and and CC cord-023134-y665agnh 1324 11 cavity cavity NN cord-023134-y665agnh 1324 12 effusions effusion NNS cord-023134-y665agnh 1324 13 , , , cord-023134-y665agnh 1324 14 clotting clotting NN cord-023134-y665agnh 1324 15 abnormalities abnormality NNS cord-023134-y665agnh 1324 16 , , , cord-023134-y665agnh 1324 17 altered alter VBN cord-023134-y665agnh 1324 18 carriage carriage NN cord-023134-y665agnh 1324 19 of of IN cord-023134-y665agnh 1324 20 drugs drug NNS cord-023134-y665agnh 1324 21 , , , cord-023134-y665agnh 1324 22 hormones hormone NNS cord-023134-y665agnh 1324 23 and and CC cord-023134-y665agnh 1324 24 electrolytes electrolyte NNS cord-023134-y665agnh 1324 25 , , , cord-023134-y665agnh 1324 26 along along IN cord-023134-y665agnh 1324 27 with with IN cord-023134-y665agnh 1324 28 acid acid NN cord-023134-y665agnh 1324 29 - - HYPH cord-023134-y665agnh 1324 30 base base NN cord-023134-y665agnh 1324 31 disturbances disturbance NNS cord-023134-y665agnh 1324 32 . . . cord-023134-y665agnh 1325 1 The the DT cord-023134-y665agnh 1325 2 aim aim NN cord-023134-y665agnh 1325 3 of of IN cord-023134-y665agnh 1325 4 the the DT cord-023134-y665agnh 1325 5 study study NN cord-023134-y665agnh 1325 6 was be VBD cord-023134-y665agnh 1325 7 to to TO cord-023134-y665agnh 1325 8 determine determine VB cord-023134-y665agnh 1325 9 the the DT cord-023134-y665agnh 1325 10 incidence incidence NN cord-023134-y665agnh 1325 11 of of IN cord-023134-y665agnh 1325 12 side side NN cord-023134-y665agnh 1325 13 effects effect NNS cord-023134-y665agnh 1325 14 encountered encounter VBN cord-023134-y665agnh 1325 15 when when WRB cord-023134-y665agnh 1325 16 administering administer VBG cord-023134-y665agnh 1325 17 20 20 CD cord-023134-y665agnh 1325 18 % % NN cord-023134-y665agnh 1325 19 intravenous intravenous JJ cord-023134-y665agnh 1325 20 human human JJ cord-023134-y665agnh 1325 21 albumin albumin NN cord-023134-y665agnh 1325 22 to to IN cord-023134-y665agnh 1325 23 dogs dog NNS cord-023134-y665agnh 1325 24 suffering suffer VBG cord-023134-y665agnh 1325 25 with with IN cord-023134-y665agnh 1325 26 hypoalbuminaemia hypoalbuminaemia NN cord-023134-y665agnh 1325 27 . . . cord-023134-y665agnh 1326 1 Animals animal NNS cord-023134-y665agnh 1326 2 were be VBD cord-023134-y665agnh 1326 3 presented present VBN cord-023134-y665agnh 1326 4 to to IN cord-023134-y665agnh 1326 5 a a DT cord-023134-y665agnh 1326 6 specialist specialist JJ cord-023134-y665agnh 1326 7 referral referral NN cord-023134-y665agnh 1326 8 centre centre NN cord-023134-y665agnh 1326 9 in in IN cord-023134-y665agnh 1326 10 Hampshire Hampshire NNP cord-023134-y665agnh 1326 11 , , , cord-023134-y665agnh 1326 12 UK UK NNP cord-023134-y665agnh 1326 13 for for IN cord-023134-y665agnh 1326 14 various various JJ cord-023134-y665agnh 1326 15 conditions condition NNS cord-023134-y665agnh 1326 16 resulting result VBG cord-023134-y665agnh 1326 17 in in IN cord-023134-y665agnh 1326 18 hypoalbuminaemia hypoalbuminaemia NN cord-023134-y665agnh 1326 19 . . . cord-023134-y665agnh 1327 1 Hypoalbuminaeamia Hypoalbuminaeamia NNP cord-023134-y665agnh 1327 2 was be VBD cord-023134-y665agnh 1327 3 considered consider VBN cord-023134-y665agnh 1327 4 to to TO cord-023134-y665agnh 1327 5 be be VB cord-023134-y665agnh 1327 6 present present JJ cord-023134-y665agnh 1327 7 when when WRB cord-023134-y665agnh 1327 8 the the DT cord-023134-y665agnh 1327 9 serum serum NN cord-023134-y665agnh 1327 10 albumin albumin NN cord-023134-y665agnh 1327 11 concentration concentration NN cord-023134-y665agnh 1327 12 was be VBD cord-023134-y665agnh 1327 13 < < XX cord-023134-y665agnh 1327 14 20g 20g NNPS cord-023134-y665agnh 1327 15 / / SYM cord-023134-y665agnh 1327 16 l l NN cord-023134-y665agnh 1327 17 . . . cord-023134-y665agnh 1328 1 A a DT cord-023134-y665agnh 1328 2 total total NN cord-023134-y665agnh 1328 3 of of IN cord-023134-y665agnh 1328 4 69 69 CD cord-023134-y665agnh 1328 5 albumin albumin NN cord-023134-y665agnh 1328 6 infusions infusion NNS cord-023134-y665agnh 1328 7 were be VBD cord-023134-y665agnh 1328 8 given give VBN cord-023134-y665agnh 1328 9 to to IN cord-023134-y665agnh 1328 10 60 60 CD cord-023134-y665agnh 1328 11 dogs dog NNS cord-023134-y665agnh 1328 12 presenting present VBG cord-023134-y665agnh 1328 13 with with IN cord-023134-y665agnh 1328 14 a a DT cord-023134-y665agnh 1328 15 serum serum NN cord-023134-y665agnh 1328 16 albumin albumin NN cord-023134-y665agnh 1328 17 concentration concentration NN cord-023134-y665agnh 1328 18 of of IN cord-023134-y665agnh 1328 19 17g 17g NNS cord-023134-y665agnh 1328 20 / / SYM cord-023134-y665agnh 1328 21 l l NN cord-023134-y665agnh 1328 22 or or CC cord-023134-y665agnh 1328 23 lower low JJR cord-023134-y665agnh 1328 24 . . . cord-023134-y665agnh 1329 1 Albumin albumin NN cord-023134-y665agnh 1329 2 was be VBD cord-023134-y665agnh 1329 3 given give VBN cord-023134-y665agnh 1329 4 as as IN cord-023134-y665agnh 1329 5 an an DT cord-023134-y665agnh 1329 6 intravenous intravenous JJ cord-023134-y665agnh 1329 7 infusion infusion NN cord-023134-y665agnh 1329 8 of of IN cord-023134-y665agnh 1329 9 800 800 CD cord-023134-y665agnh 1329 10 mg mg NN cord-023134-y665agnh 1329 11 ( ( -LRB- cord-023134-y665agnh 1329 12 4ml)/kg 4ml)/kg CD cord-023134-y665agnh 1329 13 following follow VBG cord-023134-y665agnh 1329 14 premedication premedication NN cord-023134-y665agnh 1329 15 with with IN cord-023134-y665agnh 1329 16 chlorphenamine chlorphenamine NN cord-023134-y665agnh 1329 17 . . . cord-023134-y665agnh 1330 1 The the DT cord-023134-y665agnh 1330 2 duration duration NN cord-023134-y665agnh 1330 3 of of IN cord-023134-y665agnh 1330 4 administration administration NN cord-023134-y665agnh 1330 5 was be VBD cord-023134-y665agnh 1330 6 between between IN cord-023134-y665agnh 1330 7 30 30 CD cord-023134-y665agnh 1330 8 minutes minute NNS cord-023134-y665agnh 1330 9 and and CC cord-023134-y665agnh 1330 10 4 4 CD cord-023134-y665agnh 1330 11 hours hour NNS cord-023134-y665agnh 1330 12 . . . cord-023134-y665agnh 1331 1 The the DT cord-023134-y665agnh 1331 2 dogs dog NNS cord-023134-y665agnh 1331 3 were be VBD cord-023134-y665agnh 1331 4 monitored monitor VBN cord-023134-y665agnh 1331 5 for for IN cord-023134-y665agnh 1331 6 potential potential JJ cord-023134-y665agnh 1331 7 adverse adverse JJ cord-023134-y665agnh 1331 8 reactions reaction NNS cord-023134-y665agnh 1331 9 during during IN cord-023134-y665agnh 1331 10 the the DT cord-023134-y665agnh 1331 11 administration administration NN cord-023134-y665agnh 1331 12 of of IN cord-023134-y665agnh 1331 13 albumin albumin NN cord-023134-y665agnh 1331 14 and and CC cord-023134-y665agnh 1331 15 in in IN cord-023134-y665agnh 1331 16 the the DT cord-023134-y665agnh 1331 17 post post JJ cord-023134-y665agnh 1331 18 - - JJ cord-023134-y665agnh 1331 19 infusion infusion JJ cord-023134-y665agnh 1331 20 period period NN cord-023134-y665agnh 1331 21 . . . cord-023134-y665agnh 1332 1 Potential potential JJ cord-023134-y665agnh 1332 2 adverse adverse JJ cord-023134-y665agnh 1332 3 reactions reaction NNS cord-023134-y665agnh 1332 4 included include VBD cord-023134-y665agnh 1332 5 hypotension hypotension NN cord-023134-y665agnh 1332 6 , , , cord-023134-y665agnh 1332 7 hyperthermia hyperthermia NN cord-023134-y665agnh 1332 8 , , , cord-023134-y665agnh 1332 9 tachycardia tachycardia NN cord-023134-y665agnh 1332 10 , , , cord-023134-y665agnh 1332 11 tachypnea tachypnea NNP cord-023134-y665agnh 1332 12 , , , cord-023134-y665agnh 1332 13 peripheral peripheral JJ cord-023134-y665agnh 1332 14 oedema oedema NN cord-023134-y665agnh 1332 15 , , , cord-023134-y665agnh 1332 16 agitation agitation NN cord-023134-y665agnh 1332 17 / / SYM cord-023134-y665agnh 1332 18 restlessness restlessness NN cord-023134-y665agnh 1332 19 and and CC cord-023134-y665agnh 1332 20 collapse collapse NN cord-023134-y665agnh 1332 21 . . . cord-023134-y665agnh 1333 1 None none NN cord-023134-y665agnh 1333 2 of of IN cord-023134-y665agnh 1333 3 the the DT cord-023134-y665agnh 1333 4 animals animal NNS cord-023134-y665agnh 1333 5 showed show VBD cord-023134-y665agnh 1333 6 adverse adverse JJ cord-023134-y665agnh 1333 7 reactions reaction NNS cord-023134-y665agnh 1333 8 during during IN cord-023134-y665agnh 1333 9 the the DT cord-023134-y665agnh 1333 10 administration administration NN cord-023134-y665agnh 1333 11 of of IN cord-023134-y665agnh 1333 12 albumin albumin NN cord-023134-y665agnh 1333 13 or or CC cord-023134-y665agnh 1333 14 in in IN cord-023134-y665agnh 1333 15 the the DT cord-023134-y665agnh 1333 16 post post JJ cord-023134-y665agnh 1333 17 - - JJ cord-023134-y665agnh 1333 18 infusion infusion JJ cord-023134-y665agnh 1333 19 period period NN cord-023134-y665agnh 1333 20 . . . cord-023134-y665agnh 1334 1 One one CD cord-023134-y665agnh 1334 2 animal animal NN cord-023134-y665agnh 1334 3 demonstrated demonstrate VBD cord-023134-y665agnh 1334 4 mild mild JJ cord-023134-y665agnh 1334 5 hyperaesthesia hyperaesthesia NNP cord-023134-y665agnh 1334 6 that that WDT cord-023134-y665agnh 1334 7 resolved resolve VBD cord-023134-y665agnh 1334 8 prior prior RB cord-023134-y665agnh 1334 9 to to IN cord-023134-y665agnh 1334 10 completion completion NN cord-023134-y665agnh 1334 11 of of IN cord-023134-y665agnh 1334 12 the the DT cord-023134-y665agnh 1334 13 infusion infusion NN cord-023134-y665agnh 1334 14 . . . cord-023134-y665agnh 1335 1 Of of IN cord-023134-y665agnh 1335 2 the the DT cord-023134-y665agnh 1335 3 animals animal NNS cord-023134-y665agnh 1335 4 presented present VBN cord-023134-y665agnh 1335 5 , , , cord-023134-y665agnh 1335 6 39 39 CD cord-023134-y665agnh 1335 7 survived survive VBD cord-023134-y665agnh 1335 8 to to TO cord-023134-y665agnh 1335 9 discharge discharge VB cord-023134-y665agnh 1335 10 , , , cord-023134-y665agnh 1335 11 15 15 CD cord-023134-y665agnh 1335 12 animals animal NNS cord-023134-y665agnh 1335 13 were be VBD cord-023134-y665agnh 1335 14 euthanased euthanase VBN cord-023134-y665agnh 1335 15 and and CC cord-023134-y665agnh 1335 16 6 6 CD cord-023134-y665agnh 1335 17 died die VBD cord-023134-y665agnh 1335 18 . . . cord-023134-y665agnh 1336 1 Each each DT cord-023134-y665agnh 1336 2 dog dog NN cord-023134-y665agnh 1336 3 received receive VBD cord-023134-y665agnh 1336 4 an an DT cord-023134-y665agnh 1336 5 average average NN cord-023134-y665agnh 1336 6 of of IN cord-023134-y665agnh 1336 7 1.23 1.23 CD cord-023134-y665agnh 1336 8 ( ( -LRB- cord-023134-y665agnh 1336 9 SD sd NN cord-023134-y665agnh 1336 10 0.46 0.46 CD cord-023134-y665agnh 1336 11 ) ) -RRB- cord-023134-y665agnh 1336 12 albumin albumin NN cord-023134-y665agnh 1336 13 infusions infusion NNS cord-023134-y665agnh 1336 14 during during IN cord-023134-y665agnh 1336 15 the the DT cord-023134-y665agnh 1336 16 period period NN cord-023134-y665agnh 1336 17 of of IN cord-023134-y665agnh 1336 18 hospitalisation hospitalisation NN cord-023134-y665agnh 1336 19 . . . cord-023134-y665agnh 1337 1 There there EX cord-023134-y665agnh 1337 2 was be VBD cord-023134-y665agnh 1337 3 no no DT cord-023134-y665agnh 1337 4 significant significant JJ cord-023134-y665agnh 1337 5 difference difference NN cord-023134-y665agnh 1337 6 in in IN cord-023134-y665agnh 1337 7 the the DT cord-023134-y665agnh 1337 8 starting start VBG cord-023134-y665agnh 1337 9 albumin albumin NN cord-023134-y665agnh 1337 10 concentrations concentration NNS cord-023134-y665agnh 1337 11 between between IN cord-023134-y665agnh 1337 12 the the DT cord-023134-y665agnh 1337 13 survivors survivor NNS cord-023134-y665agnh 1337 14 and and CC cord-023134-y665agnh 1337 15 nonsurvivors nonsurvivor NNS cord-023134-y665agnh 1337 16 . . . cord-023134-y665agnh 1338 1 There there EX cord-023134-y665agnh 1338 2 was be VBD cord-023134-y665agnh 1338 3 no no DT cord-023134-y665agnh 1338 4 significant significant JJ cord-023134-y665agnh 1338 5 difference difference NN cord-023134-y665agnh 1338 6 in in IN cord-023134-y665agnh 1338 7 the the DT cord-023134-y665agnh 1338 8 increase increase NN cord-023134-y665agnh 1338 9 in in IN cord-023134-y665agnh 1338 10 albumin albumin NN cord-023134-y665agnh 1338 11 concentration concentration NN cord-023134-y665agnh 1338 12 post post NN cord-023134-y665agnh 1338 13 - - NN cord-023134-y665agnh 1338 14 infusion infusion NN cord-023134-y665agnh 1338 15 between between IN cord-023134-y665agnh 1338 16 survivors survivor NNS cord-023134-y665agnh 1338 17 and and CC cord-023134-y665agnh 1338 18 non non NNS cord-023134-y665agnh 1338 19 - - NNS cord-023134-y665agnh 1338 20 survivors survivor NNS cord-023134-y665agnh 1338 21 . . . cord-023134-y665agnh 1339 1 There there EX cord-023134-y665agnh 1339 2 was be VBD cord-023134-y665agnh 1339 3 no no DT cord-023134-y665agnh 1339 4 significant significant JJ cord-023134-y665agnh 1339 5 difference difference NN cord-023134-y665agnh 1339 6 in in IN cord-023134-y665agnh 1339 7 the the DT cord-023134-y665agnh 1339 8 number number NN cord-023134-y665agnh 1339 9 of of IN cord-023134-y665agnh 1339 10 albumin albumin NN cord-023134-y665agnh 1339 11 infusions infusion NNS cord-023134-y665agnh 1339 12 between between IN cord-023134-y665agnh 1339 13 the the DT cord-023134-y665agnh 1339 14 survivors survivor NNS cord-023134-y665agnh 1339 15 and and CC cord-023134-y665agnh 1339 16 non non NNS cord-023134-y665agnh 1339 17 - - NNS cord-023134-y665agnh 1339 18 survivors survivor NNS cord-023134-y665agnh 1339 19 . . . cord-023134-y665agnh 1340 1 The the DT cord-023134-y665agnh 1340 2 concentration concentration NN cord-023134-y665agnh 1340 3 of of IN cord-023134-y665agnh 1340 4 albumin albumin NN cord-023134-y665agnh 1340 5 pre pre JJ cord-023134-y665agnh 1340 6 - - NN cord-023134-y665agnh 1340 7 infusion infusion NN cord-023134-y665agnh 1340 8 did do VBD cord-023134-y665agnh 1340 9 not not RB cord-023134-y665agnh 1340 10 negatively negatively RB cord-023134-y665agnh 1340 11 impact impact VB cord-023134-y665agnh 1340 12 on on IN cord-023134-y665agnh 1340 13 survival survival NN cord-023134-y665agnh 1340 14 and and CC cord-023134-y665agnh 1340 15 discharge discharge NN cord-023134-y665agnh 1340 16 from from IN cord-023134-y665agnh 1340 17 the the DT cord-023134-y665agnh 1340 18 hospital hospital NN cord-023134-y665agnh 1340 19 . . . cord-023134-y665agnh 1341 1 The the DT cord-023134-y665agnh 1341 2 results result NNS cord-023134-y665agnh 1341 3 of of IN cord-023134-y665agnh 1341 4 this this DT cord-023134-y665agnh 1341 5 study study NN cord-023134-y665agnh 1341 6 demonstrate demonstrate VBP cord-023134-y665agnh 1341 7 no no DT cord-023134-y665agnh 1341 8 significant significant JJ cord-023134-y665agnh 1341 9 complications complication NNS cord-023134-y665agnh 1341 10 during during IN cord-023134-y665agnh 1341 11 or or CC cord-023134-y665agnh 1341 12 following follow VBG cord-023134-y665agnh 1341 13 administration administration NN cord-023134-y665agnh 1341 14 of of IN cord-023134-y665agnh 1341 15 20 20 CD cord-023134-y665agnh 1341 16 % % NN cord-023134-y665agnh 1341 17 Human human JJ cord-023134-y665agnh 1341 18 albumin albumin NN cord-023134-y665agnh 1341 19 solution solution NN cord-023134-y665agnh 1341 20 in in IN cord-023134-y665agnh 1341 21 dogs dog NNS cord-023134-y665agnh 1341 22 . . . cord-023134-y665agnh 1342 1 There there EX cord-023134-y665agnh 1342 2 was be VBD cord-023134-y665agnh 1342 3 no no DT cord-023134-y665agnh 1342 4 association association NN cord-023134-y665agnh 1342 5 between between IN cord-023134-y665agnh 1342 6 the the DT cord-023134-y665agnh 1342 7 administration administration NN cord-023134-y665agnh 1342 8 of of IN cord-023134-y665agnh 1342 9 albumin albumin NN cord-023134-y665agnh 1342 10 , , , cord-023134-y665agnh 1342 11 number number NN cord-023134-y665agnh 1342 12 of of IN cord-023134-y665agnh 1342 13 albumin albumin NN cord-023134-y665agnh 1342 14 infusions infusion NNS cord-023134-y665agnh 1342 15 or or CC cord-023134-y665agnh 1342 16 amount amount NN cord-023134-y665agnh 1342 17 of of IN cord-023134-y665agnh 1342 18 albumin albumin NN cord-023134-y665agnh 1342 19 administered administer VBN cord-023134-y665agnh 1342 20 in in IN cord-023134-y665agnh 1342 21 any any DT cord-023134-y665agnh 1342 22 patient patient NN cord-023134-y665agnh 1342 23 and and CC cord-023134-y665agnh 1342 24 outcome outcome NN cord-023134-y665agnh 1342 25 . . . cord-023134-y665agnh 1343 1 Albumin albumin NN cord-023134-y665agnh 1343 2 infusion infusion NN cord-023134-y665agnh 1343 3 may may MD cord-023134-y665agnh 1343 4 improve improve VB cord-023134-y665agnh 1343 5 the the DT cord-023134-y665agnh 1343 6 chances chance NNS cord-023134-y665agnh 1343 7 of of IN cord-023134-y665agnh 1343 8 severely severely RB cord-023134-y665agnh 1343 9 hypoalbuminaemic hypoalbuminaemic JJ cord-023134-y665agnh 1343 10 dogs dog NNS cord-023134-y665agnh 1343 11 surviving survive VBG cord-023134-y665agnh 1343 12 to to TO cord-023134-y665agnh 1343 13 be be VB cord-023134-y665agnh 1343 14 discharged discharge VBN cord-023134-y665agnh 1343 15 from from IN cord-023134-y665agnh 1343 16 the the DT cord-023134-y665agnh 1343 17 hospital hospital NN cord-023134-y665agnh 1343 18 . . . cord-023134-y665agnh 1344 1 The the DT cord-023134-y665agnh 1344 2 use use NN cord-023134-y665agnh 1344 3 of of IN cord-023134-y665agnh 1344 4 human human JJ cord-023134-y665agnh 1344 5 albumin albumin NN cord-023134-y665agnh 1344 6 for for IN cord-023134-y665agnh 1344 7 this this DT cord-023134-y665agnh 1344 8 purpose purpose NN cord-023134-y665agnh 1344 9 enables enable VBZ cord-023134-y665agnh 1344 10 the the DT cord-023134-y665agnh 1344 11 limited limited JJ cord-023134-y665agnh 1344 12 supplies supply NNS cord-023134-y665agnh 1344 13 of of IN cord-023134-y665agnh 1344 14 canine canine JJ cord-023134-y665agnh 1344 15 plasma plasma NN cord-023134-y665agnh 1344 16 to to TO cord-023134-y665agnh 1344 17 be be VB cord-023134-y665agnh 1344 18 reserved reserve VBN cord-023134-y665agnh 1344 19 for for IN cord-023134-y665agnh 1344 20 dogs dog NNS cord-023134-y665agnh 1344 21 needing need VBG cord-023134-y665agnh 1344 22 plasma plasma NN cord-023134-y665agnh 1344 23 transfusion transfusion NN cord-023134-y665agnh 1344 24 for for IN cord-023134-y665agnh 1344 25 other other JJ cord-023134-y665agnh 1344 26 reasons reason NNS cord-023134-y665agnh 1344 27 . . . cord-023134-y665agnh 1345 1 Recently recently RB cord-023134-y665agnh 1345 2 , , , cord-023134-y665agnh 1345 3 metabolic metabolic JJ cord-023134-y665agnh 1345 4 syndrome syndrome NN cord-023134-y665agnh 1345 5 has have VBZ cord-023134-y665agnh 1345 6 gained gain VBN cord-023134-y665agnh 1345 7 attention attention NN cord-023134-y665agnh 1345 8 in in IN cord-023134-y665agnh 1345 9 human human JJ cord-023134-y665agnh 1345 10 medicine medicine NN cord-023134-y665agnh 1345 11 given give VBN cord-023134-y665agnh 1345 12 its -PRON- PRP$ cord-023134-y665agnh 1345 13 associations association NNS cord-023134-y665agnh 1345 14 with with IN cord-023134-y665agnh 1345 15 development development NN cord-023134-y665agnh 1345 16 of of IN cord-023134-y665agnh 1345 17 diabetes diabetes NN cord-023134-y665agnh 1345 18 mellitus mellitus NN cord-023134-y665agnh 1345 19 and and CC cord-023134-y665agnh 1345 20 cardiovascular cardiovascular JJ cord-023134-y665agnh 1345 21 diseases disease NNS cord-023134-y665agnh 1345 22 . . . cord-023134-y665agnh 1346 1 Canine canine JJ cord-023134-y665agnh 1346 2 obesity obesity NN cord-023134-y665agnh 1346 3 is be VBZ cord-023134-y665agnh 1346 4 associated associate VBN cord-023134-y665agnh 1346 5 with with IN cord-023134-y665agnh 1346 6 the the DT cord-023134-y665agnh 1346 7 development development NN cord-023134-y665agnh 1346 8 of of IN cord-023134-y665agnh 1346 9 insulin insulin NN cord-023134-y665agnh 1346 10 resistance resistance NN cord-023134-y665agnh 1346 11 , , , cord-023134-y665agnh 1346 12 altered alter VBN cord-023134-y665agnh 1346 13 lipid lipid NN cord-023134-y665agnh 1346 14 profiles profile NNS cord-023134-y665agnh 1346 15 , , , cord-023134-y665agnh 1346 16 and and CC cord-023134-y665agnh 1346 17 mild mild JJ cord-023134-y665agnh 1346 18 hypertension hypertension NN cord-023134-y665agnh 1346 19 , , , cord-023134-y665agnh 1346 20 but but CC cord-023134-y665agnh 1346 21 the the DT cord-023134-y665agnh 1346 22 authors author NNS cord-023134-y665agnh 1346 23 are be VBP cord-023134-y665agnh 1346 24 not not RB cord-023134-y665agnh 1346 25 aware aware JJ cord-023134-y665agnh 1346 26 of of IN cord-023134-y665agnh 1346 27 any any DT cord-023134-y665agnh 1346 28 existing exist VBG cord-023134-y665agnh 1346 29 studies study NNS cord-023134-y665agnh 1346 30 examining examine VBG cord-023134-y665agnh 1346 31 the the DT cord-023134-y665agnh 1346 32 existence existence NN cord-023134-y665agnh 1346 33 of of IN cord-023134-y665agnh 1346 34 MS MS NNP cord-023134-y665agnh 1346 35 in in IN cord-023134-y665agnh 1346 36 obese obese JJ cord-023134-y665agnh 1346 37 dogs dog NNS cord-023134-y665agnh 1346 38 . . . cord-023134-y665agnh 1347 1 Thirty thirty CD cord-023134-y665agnh 1347 2 - - HYPH cord-023134-y665agnh 1347 3 five five CD cord-023134-y665agnh 1347 4 obese obese JJ cord-023134-y665agnh 1347 5 dogs dog NNS cord-023134-y665agnh 1347 6 were be VBD cord-023134-y665agnh 1347 7 assessed assess VBN cord-023134-y665agnh 1347 8 before before RB cord-023134-y665agnh 1347 9 and and CC cord-023134-y665agnh 1347 10 after after IN cord-023134-y665agnh 1347 11 weight weight NN cord-023134-y665agnh 1347 12 loss loss NN cord-023134-y665agnh 1347 13 . . . cord-023134-y665agnh 1348 1 The the DT cord-023134-y665agnh 1348 2 guidelines guideline NNS cord-023134-y665agnh 1348 3 of of IN cord-023134-y665agnh 1348 4 the the DT cord-023134-y665agnh 1348 5 International International NNP cord-023134-y665agnh 1348 6 Diabetes Diabetes NNP cord-023134-y665agnh 1348 7 Federation Federation NNP cord-023134-y665agnh 1348 8 were be VBD cord-023134-y665agnh 1348 9 modified modify VBN cord-023134-y665agnh 1348 10 in in IN cord-023134-y665agnh 1348 11 order order NN cord-023134-y665agnh 1348 12 to to TO cord-023134-y665agnh 1348 13 produce produce VB cord-023134-y665agnh 1348 14 a a DT cord-023134-y665agnh 1348 15 definition definition NN cord-023134-y665agnh 1348 16 for for IN cord-023134-y665agnh 1348 17 canine canine JJ cord-023134-y665agnh 1348 18 metabolic metabolic JJ cord-023134-y665agnh 1348 19 syndrome syndrome NN cord-023134-y665agnh 1348 20 ( ( -LRB- cord-023134-y665agnh 1348 21 CMS CMS NNP cord-023134-y665agnh 1348 22 ) ) -RRB- cord-023134-y665agnh 1348 23 , , , cord-023134-y665agnh 1348 24 which which WDT cord-023134-y665agnh 1348 25 included include VBD cord-023134-y665agnh 1348 26 a a DT cord-023134-y665agnh 1348 27 measure measure NN cord-023134-y665agnh 1348 28 of of IN cord-023134-y665agnh 1348 29 adiposity adiposity NN cord-023134-y665agnh 1348 30 ( ( -LRB- cord-023134-y665agnh 1348 31 using use VBG cord-023134-y665agnh 1348 32 a a DT cord-023134-y665agnh 1348 33 9-point 9-point CD cord-023134-y665agnh 1348 34 body body NN cord-023134-y665agnh 1348 35 condition condition NN cord-023134-y665agnh 1348 36 score score NN cord-023134-y665agnh 1348 37 [ [ -LRB- cord-023134-y665agnh 1348 38 BCS BCS NNP cord-023134-y665agnh 1348 39 ] ] -RRB- cord-023134-y665agnh 1348 40 ) ) -RRB- cord-023134-y665agnh 1348 41 , , , cord-023134-y665agnh 1348 42 systolic systolic JJ cord-023134-y665agnh 1348 43 blood blood NN cord-023134-y665agnh 1348 44 pressure pressure NN cord-023134-y665agnh 1348 45 , , , cord-023134-y665agnh 1348 46 plasma plasma NN cord-023134-y665agnh 1348 47 cholesterol cholesterol NN cord-023134-y665agnh 1348 48 , , , cord-023134-y665agnh 1348 49 plasma plasma NN cord-023134-y665agnh 1348 50 triglyceride triglyceride NN cord-023134-y665agnh 1348 51 , , , cord-023134-y665agnh 1348 52 plasma plasma NN cord-023134-y665agnh 1348 53 glucose glucose NN cord-023134-y665agnh 1348 54 , , , cord-023134-y665agnh 1348 55 and and CC cord-023134-y665agnh 1348 56 urine urine NN cord-023134-y665agnh 1348 57 protein protein NN cord-023134-y665agnh 1348 58 : : : cord-023134-y665agnh 1348 59 creatinine creatinine NN cord-023134-y665agnh 1348 60 ratio ratio NN cord-023134-y665agnh 1348 61 ( ( -LRB- cord-023134-y665agnh 1348 62 UPCR UPCR NNP cord-023134-y665agnh 1348 63 ) ) -RRB- cord-023134-y665agnh 1348 64 . . . cord-023134-y665agnh 1349 1 By by IN cord-023134-y665agnh 1349 2 way way NN cord-023134-y665agnh 1349 3 of of IN cord-023134-y665agnh 1349 4 comparison comparison NN cord-023134-y665agnh 1349 5 , , , cord-023134-y665agnh 1349 6 total total JJ cord-023134-y665agnh 1349 7 and and CC cord-023134-y665agnh 1349 8 regional regional JJ cord-023134-y665agnh 1349 9 body body NN cord-023134-y665agnh 1349 10 fat fat NN cord-023134-y665agnh 1349 11 mass mass NN cord-023134-y665agnh 1349 12 were be VBD cord-023134-y665agnh 1349 13 assessed assess VBN cord-023134-y665agnh 1349 14 by by IN cord-023134-y665agnh 1349 15 dual dual JJ cord-023134-y665agnh 1349 16 - - HYPH cord-023134-y665agnh 1349 17 energy energy NN cord-023134-y665agnh 1349 18 X x NN cord-023134-y665agnh 1349 19 - - NN cord-023134-y665agnh 1349 20 ray ray NN cord-023134-y665agnh 1349 21 absorptiometry absorptiometry NN cord-023134-y665agnh 1349 22 , , , cord-023134-y665agnh 1349 23 whilst whilst IN cord-023134-y665agnh 1349 24 adiponectin adiponectin NN cord-023134-y665agnh 1349 25 , , , cord-023134-y665agnh 1349 26 insulin insulin NN cord-023134-y665agnh 1349 27 , , , cord-023134-y665agnh 1349 28 and and CC cord-023134-y665agnh 1349 29 high high JJ cord-023134-y665agnh 1349 30 - - HYPH cord-023134-y665agnh 1349 31 sensitivity sensitivity NN cord-023134-y665agnh 1349 32 C c NN cord-023134-y665agnh 1349 33 - - HYPH cord-023134-y665agnh 1349 34 reactive reactive JJ cord-023134-y665agnh 1349 35 protein protein NN cord-023134-y665agnh 1349 36 ( ( -LRB- cord-023134-y665agnh 1349 37 hsCRP hscrp NN cord-023134-y665agnh 1349 38 ) ) -RRB- cord-023134-y665agnh 1349 39 were be VBD cord-023134-y665agnh 1349 40 also also RB cord-023134-y665agnh 1349 41 assessed assess VBN cord-023134-y665agnh 1349 42 with with IN cord-023134-y665agnh 1349 43 validated validate VBN cord-023134-y665agnh 1349 44 assays assay NNS cord-023134-y665agnh 1349 45 . . . cord-023134-y665agnh 1350 1 Systolic systolic JJ cord-023134-y665agnh 1350 2 blood blood NN cord-023134-y665agnh 1350 3 pressure pressure NN cord-023134-y665agnh 1350 4 ( ( -LRB- cord-023134-y665agnh 1350 5 P=0.008 P=0.008 NNP cord-023134-y665agnh 1350 6 ) ) -RRB- cord-023134-y665agnh 1350 7 , , , cord-023134-y665agnh 1350 8 cholesterol cholesterol NN cord-023134-y665agnh 1350 9 ( ( -LRB- cord-023134-y665agnh 1350 10 P=0.003 P=0.003 NNP cord-023134-y665agnh 1350 11 ) ) -RRB- cord-023134-y665agnh 1350 12 , , , cord-023134-y665agnh 1350 13 triglyceride triglyceride NN cord-023134-y665agnh 1350 14 ( ( -LRB- cord-023134-y665agnh 1350 15 P=0.018 P=0.018 NNP cord-023134-y665agnh 1350 16 ) ) -RRB- cord-023134-y665agnh 1350 17 , , , cord-023134-y665agnh 1350 18 insulin insulin NN cord-023134-y665agnh 1350 19 ( ( -LRB- cord-023134-y665agnh 1350 20 P<0.001 P<0.001 NNP cord-023134-y665agnh 1350 21 ) ) -RRB- cord-023134-y665agnh 1350 22 , , , cord-023134-y665agnh 1350 23 and and CC cord-023134-y665agnh 1350 24 UPCR UPCR NNP cord-023134-y665agnh 1350 25 ( ( -LRB- cord-023134-y665agnh 1350 26 P=0.034 P=0.034 NNP cord-023134-y665agnh 1350 27 ) ) -RRB- cord-023134-y665agnh 1350 28 all all DT cord-023134-y665agnh 1350 29 decreased decrease VBD cord-023134-y665agnh 1350 30 after after IN cord-023134-y665agnh 1350 31 weight weight NN cord-023134-y665agnh 1350 32 loss loss NN cord-023134-y665agnh 1350 33 , , , cord-023134-y665agnh 1350 34 whilst whilst IN cord-023134-y665agnh 1350 35 plasma plasma NN cord-023134-y665agnh 1350 36 adiponectin adiponectin NN cord-023134-y665agnh 1350 37 increased increase VBD cord-023134-y665agnh 1350 38 ( ( -LRB- cord-023134-y665agnh 1350 39 P=0.001 P=0.001 NNP cord-023134-y665agnh 1350 40 ) ) -RRB- cord-023134-y665agnh 1350 41 . . . cord-023134-y665agnh 1351 1 However however RB cord-023134-y665agnh 1351 2 , , , cord-023134-y665agnh 1351 3 hsCRP hscrp NN cord-023134-y665agnh 1351 4 did do VBD cord-023134-y665agnh 1351 5 not not RB cord-023134-y665agnh 1351 6 change change VB cord-023134-y665agnh 1351 7 with with IN cord-023134-y665agnh 1351 8 weight weight NN cord-023134-y665agnh 1351 9 loss loss NN cord-023134-y665agnh 1351 10 . . . cord-023134-y665agnh 1352 1 Prior prior RB cord-023134-y665agnh 1352 2 to to IN cord-023134-y665agnh 1352 3 weight weight NN cord-023134-y665agnh 1352 4 loss loss NN cord-023134-y665agnh 1352 5 , , , cord-023134-y665agnh 1352 6 10 10 CD cord-023134-y665agnh 1352 7 dogs dog NNS cord-023134-y665agnh 1352 8 were be VBD cord-023134-y665agnh 1352 9 defined define VBN cord-023134-y665agnh 1352 10 as as IN cord-023134-y665agnh 1352 11 having have VBG cord-023134-y665agnh 1352 12 CMS CMS NNP cord-023134-y665agnh 1352 13 . . . cord-023134-y665agnh 1353 1 There there EX cord-023134-y665agnh 1353 2 was be VBD cord-023134-y665agnh 1353 3 no no DT cord-023134-y665agnh 1353 4 difference difference NN cord-023134-y665agnh 1353 5 in in IN cord-023134-y665agnh 1353 6 total total JJ cord-023134-y665agnh 1353 7 or or CC cord-023134-y665agnh 1353 8 regional regional JJ cord-023134-y665agnh 1353 9 body body NN cord-023134-y665agnh 1353 10 fat fat NN cord-023134-y665agnh 1353 11 mass mass NN cord-023134-y665agnh 1353 12 between between IN cord-023134-y665agnh 1353 13 these these DT cord-023134-y665agnh 1353 14 dogs dog NNS cord-023134-y665agnh 1353 15 and and CC cord-023134-y665agnh 1353 16 those those DT cord-023134-y665agnh 1353 17 who who WP cord-023134-y665agnh 1353 18 did do VBD cord-023134-y665agnh 1353 19 not not RB cord-023134-y665agnh 1353 20 fit fit VB cord-023134-y665agnh 1353 21 the the DT cord-023134-y665agnh 1353 22 definition definition NN cord-023134-y665agnh 1353 23 of of IN cord-023134-y665agnh 1353 24 CMS CMS NNP cord-023134-y665agnh 1353 25 . . . cord-023134-y665agnh 1354 1 However however RB cord-023134-y665agnh 1354 2 , , , cord-023134-y665agnh 1354 3 plasma plasma NN cord-023134-y665agnh 1354 4 adiponectin adiponectin NN cord-023134-y665agnh 1354 5 concentration concentration NN cord-023134-y665agnh 1354 6 was be VBD cord-023134-y665agnh 1354 7 less less JJR cord-023134-y665agnh 1354 8 ( ( -LRB- cord-023134-y665agnh 1354 9 P=0.004 P=0.004 NNP cord-023134-y665agnh 1354 10 ) ) -RRB- cord-023134-y665agnh 1354 11 , , , cord-023134-y665agnh 1354 12 and and CC cord-023134-y665agnh 1354 13 plasma plasma NN cord-023134-y665agnh 1354 14 insulin insulin NN cord-023134-y665agnh 1354 15 concentration concentration NN cord-023134-y665agnh 1354 16 was be VBD cord-023134-y665agnh 1354 17 greater great JJR cord-023134-y665agnh 1354 18 ( ( -LRB- cord-023134-y665agnh 1354 19 P=0.01 p=0.01 JJ cord-023134-y665agnh 1354 20 ) ) -RRB- cord-023134-y665agnh 1354 21 in in IN cord-023134-y665agnh 1354 22 CMS CMS NNP cord-023134-y665agnh 1354 23 dogs dog NNS cord-023134-y665agnh 1354 24 . . . cord-023134-y665agnh 1355 1 In in IN cord-023134-y665agnh 1355 2 this this DT cord-023134-y665agnh 1355 3 study study NN cord-023134-y665agnh 1355 4 , , , cord-023134-y665agnh 1355 5 up up IN cord-023134-y665agnh 1355 6 to to IN cord-023134-y665agnh 1355 7 a a DT cord-023134-y665agnh 1355 8 third third NN cord-023134-y665agnh 1355 9 of of IN cord-023134-y665agnh 1355 10 obese obese JJ cord-023134-y665agnh 1355 11 dogs dog NNS cord-023134-y665agnh 1355 12 suffer suffer VBP cord-023134-y665agnh 1355 13 from from IN cord-023134-y665agnh 1355 14 CMS CMS NNP cord-023134-y665agnh 1355 15 , , , cord-023134-y665agnh 1355 16 and and CC cord-023134-y665agnh 1355 17 this this DT cord-023134-y665agnh 1355 18 is be VBZ cord-023134-y665agnh 1355 19 characterized characterize VBN cord-023134-y665agnh 1355 20 by by IN cord-023134-y665agnh 1355 21 hypoadiponectinaemia hypoadiponectinaemia NNP cord-023134-y665agnh 1355 22 and and CC cord-023134-y665agnh 1355 23 hyperinsulinaemia hyperinsulinaemia NNP cord-023134-y665agnh 1355 24 . . . cord-023134-y665agnh 1356 1 These these DT cord-023134-y665agnh 1356 2 studies study NNS cord-023134-y665agnh 1356 3 can can MD cord-023134-y665agnh 1356 4 form form VB cord-023134-y665agnh 1356 5 the the DT cord-023134-y665agnh 1356 6 basis basis NN cord-023134-y665agnh 1356 7 of of IN cord-023134-y665agnh 1356 8 further further JJ cord-023134-y665agnh 1356 9 investigations investigation NNS cord-023134-y665agnh 1356 10 to to TO cord-023134-y665agnh 1356 11 determine determine VB cord-023134-y665agnh 1356 12 pathogenetic pathogenetic JJ cord-023134-y665agnh 1356 13 mechanisms mechanism NNS cord-023134-y665agnh 1356 14 and and CC cord-023134-y665agnh 1356 15 the the DT cord-023134-y665agnh 1356 16 health health NN cord-023134-y665agnh 1356 17 significance significance NN cord-023134-y665agnh 1356 18 for for IN cord-023134-y665agnh 1356 19 dogs dog NNS cord-023134-y665agnh 1356 20 , , , cord-023134-y665agnh 1356 21 in in IN cord-023134-y665agnh 1356 22 terms term NNS cord-023134-y665agnh 1356 23 of of IN cord-023134-y665agnh 1356 24 disease disease NN cord-023134-y665agnh 1356 25 associations association NNS cord-023134-y665agnh 1356 26 and and CC cord-023134-y665agnh 1356 27 outcomes outcome NNS cord-023134-y665agnh 1356 28 of of IN cord-023134-y665agnh 1356 29 weight weight NN cord-023134-y665agnh 1356 30 loss loss NN cord-023134-y665agnh 1356 31 . . . cord-023134-y665agnh 1357 1 Cystourethroscopy Cystourethroscopy NNP cord-023134-y665agnh 1357 2 has have VBZ cord-023134-y665agnh 1357 3 greatly greatly RB cord-023134-y665agnh 1357 4 enhanced enhance VBN cord-023134-y665agnh 1357 5 the the DT cord-023134-y665agnh 1357 6 diagnosis diagnosis NN cord-023134-y665agnh 1357 7 and and CC cord-023134-y665agnh 1357 8 treatment treatment NN cord-023134-y665agnh 1357 9 of of IN cord-023134-y665agnh 1357 10 numerous numerous JJ cord-023134-y665agnh 1357 11 conditions condition NNS cord-023134-y665agnh 1357 12 in in IN cord-023134-y665agnh 1357 13 veterinary veterinary JJ cord-023134-y665agnh 1357 14 medicine medicine NN cord-023134-y665agnh 1357 15 . . . cord-023134-y665agnh 1358 1 Rigid rigid JJ cord-023134-y665agnh 1358 2 telescopes telescope NNS cord-023134-y665agnh 1358 3 used use VBN cord-023134-y665agnh 1358 4 in in IN cord-023134-y665agnh 1358 5 female female JJ cord-023134-y665agnh 1358 6 cytoscopy cytoscopy NNS cord-023134-y665agnh 1358 7 provide provide VBP cord-023134-y665agnh 1358 8 well well RB cord-023134-y665agnh 1358 9 - - HYPH cord-023134-y665agnh 1358 10 illuminated illuminate VBN cord-023134-y665agnh 1358 11 highly highly RB cord-023134-y665agnh 1358 12 detailed detail VBN cord-023134-y665agnh 1358 13 images image NNS cord-023134-y665agnh 1358 14 using use VBG cord-023134-y665agnh 1358 15 rod rod NN cord-023134-y665agnh 1358 16 lens lens NN cord-023134-y665agnh 1358 17 system system NN cord-023134-y665agnh 1358 18 technology technology NN cord-023134-y665agnh 1358 19 . . . cord-023134-y665agnh 1359 1 The the DT cord-023134-y665agnh 1359 2 flexible flexible JJ cord-023134-y665agnh 1359 3 ureteroscope ureteroscope NN cord-023134-y665agnh 1359 4 has have VBZ cord-023134-y665agnh 1359 5 been be VBN cord-023134-y665agnh 1359 6 used use VBN cord-023134-y665agnh 1359 7 for for IN cord-023134-y665agnh 1359 8 male male JJ cord-023134-y665agnh 1359 9 urethrocytoscopy urethrocytoscopy NN cord-023134-y665agnh 1359 10 but but CC cord-023134-y665agnh 1359 11 is be VBZ cord-023134-y665agnh 1359 12 limited limit VBN cord-023134-y665agnh 1359 13 in in IN cord-023134-y665agnh 1359 14 image image NN cord-023134-y665agnh 1359 15 quality quality NN cord-023134-y665agnh 1359 16 and and CC cord-023134-y665agnh 1359 17 procedural procedural JJ cord-023134-y665agnh 1359 18 abilities ability NNS cord-023134-y665agnh 1359 19 due due JJ cord-023134-y665agnh 1359 20 to to IN cord-023134-y665agnh 1359 21 the the DT cord-023134-y665agnh 1359 22 fiberoptic fiberoptic JJ cord-023134-y665agnh 1359 23 system system NN cord-023134-y665agnh 1359 24 , , , cord-023134-y665agnh 1359 25 diminished diminish VBD cord-023134-y665agnh 1359 26 illumination illumination NN cord-023134-y665agnh 1359 27 , , , cord-023134-y665agnh 1359 28 and and CC cord-023134-y665agnh 1359 29 smaller small JJR cord-023134-y665agnh 1359 30 working working NN cord-023134-y665agnh 1359 31 channel channel NN cord-023134-y665agnh 1359 32 . . . cord-023134-y665agnh 1360 1 The the DT cord-023134-y665agnh 1360 2 purpose purpose NN cord-023134-y665agnh 1360 3 of of IN cord-023134-y665agnh 1360 4 this this DT cord-023134-y665agnh 1360 5 study study NN cord-023134-y665agnh 1360 6 was be VBD cord-023134-y665agnh 1360 7 to to TO cord-023134-y665agnh 1360 8 describe describe VB cord-023134-y665agnh 1360 9 the the DT cord-023134-y665agnh 1360 10 technique technique NN cord-023134-y665agnh 1360 11 , , , cord-023134-y665agnh 1360 12 efficacy efficacy NN cord-023134-y665agnh 1360 13 , , , cord-023134-y665agnh 1360 14 and and CC cord-023134-y665agnh 1360 15 complications complication NNS cord-023134-y665agnh 1360 16 using use VBG cord-023134-y665agnh 1360 17 a a DT cord-023134-y665agnh 1360 18 novel novel JJ cord-023134-y665agnh 1360 19 percutaneous percutaneous JJ cord-023134-y665agnh 1360 20 perineal perineal NN cord-023134-y665agnh 1360 21 approach approach NN cord-023134-y665agnh 1360 22 to to IN cord-023134-y665agnh 1360 23 the the DT cord-023134-y665agnh 1360 24 male male JJ cord-023134-y665agnh 1360 25 urethra urethra NN cord-023134-y665agnh 1360 26 in in IN cord-023134-y665agnh 1360 27 order order NN cord-023134-y665agnh 1360 28 to to TO cord-023134-y665agnh 1360 29 gain gain VB cord-023134-y665agnh 1360 30 access access NN cord-023134-y665agnh 1360 31 for for IN cord-023134-y665agnh 1360 32 rigid rigid JJ cord-023134-y665agnh 1360 33 cystoscopy cystoscopy NN cord-023134-y665agnh 1360 34 . . . cord-023134-y665agnh 1361 1 The the DT cord-023134-y665agnh 1361 2 perineal perineal JJ cord-023134-y665agnh 1361 3 approach approach NN cord-023134-y665agnh 1361 4 was be VBD cord-023134-y665agnh 1361 5 performed perform VBN cord-023134-y665agnh 1361 6 ten ten CD cord-023134-y665agnh 1361 7 times time NNS cord-023134-y665agnh 1361 8 in in IN cord-023134-y665agnh 1361 9 nine nine CD cord-023134-y665agnh 1361 10 dogs dog NNS cord-023134-y665agnh 1361 11 for for IN cord-023134-y665agnh 1361 12 ectopic ectopic JJ cord-023134-y665agnh 1361 13 ureter ureter NN cord-023134-y665agnh 1361 14 laser laser NN cord-023134-y665agnh 1361 15 ablation ablation NN cord-023134-y665agnh 1361 16 of of IN cord-023134-y665agnh 1361 17 idiopathic idiopathic JJ cord-023134-y665agnh 1361 18 renal renal JJ cord-023134-y665agnh 1361 19 hematuria hematuria NN cord-023134-y665agnh 1361 20 sclerotherapy sclerotherapy NN cord-023134-y665agnh 1361 21 . . . cord-023134-y665agnh 1362 1 The the DT cord-023134-y665agnh 1362 2 dogs dog NNS cord-023134-y665agnh 1362 3 were be VBD cord-023134-y665agnh 1362 4 placed place VBN cord-023134-y665agnh 1362 5 in in IN cord-023134-y665agnh 1362 6 dorsal dorsal JJ cord-023134-y665agnh 1362 7 recumbency recumbency NN cord-023134-y665agnh 1362 8 . . . cord-023134-y665agnh 1363 1 Using use VBG cord-023134-y665agnh 1363 2 fluoroscopic fluoroscopic JJ cord-023134-y665agnh 1363 3 guidance guidance NN cord-023134-y665agnh 1363 4 , , , cord-023134-y665agnh 1363 5 an an DT cord-023134-y665agnh 1363 6 18 18 CD cord-023134-y665agnh 1363 7 gauge gauge NN cord-023134-y665agnh 1363 8 renal renal JJ cord-023134-y665agnh 1363 9 access access NN cord-023134-y665agnh 1363 10 needle needle NN cord-023134-y665agnh 1363 11 was be VBD cord-023134-y665agnh 1363 12 advanced advanced JJ cord-023134-y665agnh 1363 13 trans trans NNP cord-023134-y665agnh 1363 14 - - NN cord-023134-y665agnh 1363 15 perineally perineally NN cord-023134-y665agnh 1363 16 into into IN cord-023134-y665agnh 1363 17 the the DT cord-023134-y665agnh 1363 18 pelvic pelvic JJ cord-023134-y665agnh 1363 19 urethra urethra NN cord-023134-y665agnh 1363 20 . . . cord-023134-y665agnh 1364 1 Guidewire guidewire JJ cord-023134-y665agnh 1364 2 access access NN cord-023134-y665agnh 1364 3 was be VBD cord-023134-y665agnh 1364 4 obtained obtain VBN cord-023134-y665agnh 1364 5 and and CC cord-023134-y665agnh 1364 6 the the DT cord-023134-y665agnh 1364 7 access access NN cord-023134-y665agnh 1364 8 site site NN cord-023134-y665agnh 1364 9 dilated dilate VBN cord-023134-y665agnh 1364 10 to to TO cord-023134-y665agnh 1364 11 accept accept VB cord-023134-y665agnh 1364 12 a a DT cord-023134-y665agnh 1364 13 16Fr 16fr CD cord-023134-y665agnh 1364 14 peel peel VB cord-023134-y665agnh 1364 15 - - HYPH cord-023134-y665agnh 1364 16 away away RP cord-023134-y665agnh 1364 17 sheath sheath NN cord-023134-y665agnh 1364 18 . . . cord-023134-y665agnh 1365 1 A a DT cord-023134-y665agnh 1365 2 rigid rigid JJ cord-023134-y665agnh 1365 3 cystoscope cystoscope NN cord-023134-y665agnh 1365 4 was be VBD cord-023134-y665agnh 1365 5 then then RB cord-023134-y665agnh 1365 6 placed place VBN cord-023134-y665agnh 1365 7 through through IN cord-023134-y665agnh 1365 8 the the DT cord-023134-y665agnh 1365 9 sheath sheath NN cord-023134-y665agnh 1365 10 to to TO cord-023134-y665agnh 1365 11 perform perform VB cord-023134-y665agnh 1365 12 the the DT cord-023134-y665agnh 1365 13 procedures procedure NNS cord-023134-y665agnh 1365 14 . . . cord-023134-y665agnh 1366 1 Urinary urinary JJ cord-023134-y665agnh 1366 2 catheters catheter NNS cord-023134-y665agnh 1366 3 were be VBD cord-023134-y665agnh 1366 4 placed place VBN cord-023134-y665agnh 1366 5 following follow VBG cord-023134-y665agnh 1366 6 three three CD cord-023134-y665agnh 1366 7 of of IN cord-023134-y665agnh 1366 8 ten ten CD cord-023134-y665agnh 1366 9 procedures procedure NNS cord-023134-y665agnh 1366 10 for for IN cord-023134-y665agnh 1366 11 three three CD cord-023134-y665agnh 1366 12 to to TO cord-023134-y665agnh 1366 13 eighteen eighteen CD cord-023134-y665agnh 1366 14 hours hour NNS cord-023134-y665agnh 1366 15 . . . cord-023134-y665agnh 1367 1 The the DT cord-023134-y665agnh 1367 2 only only RB cord-023134-y665agnh 1367 3 identified identify VBN cord-023134-y665agnh 1367 4 peri peri JJ cord-023134-y665agnh 1367 5 - - HYPH cord-023134-y665agnh 1367 6 operative operative JJ cord-023134-y665agnh 1367 7 minor minor JJ cord-023134-y665agnh 1367 8 complication complication NN cord-023134-y665agnh 1367 9 included include VBD cord-023134-y665agnh 1367 10 urination urination NN cord-023134-y665agnh 1367 11 form form NN cord-023134-y665agnh 1367 12 the the DT cord-023134-y665agnh 1367 13 perineal perineal NN cord-023134-y665agnh 1367 14 site site NN cord-023134-y665agnh 1367 15 approximately approximately RB cord-023134-y665agnh 1367 16 six six CD cord-023134-y665agnh 1367 17 hours hour NNS cord-023134-y665agnh 1367 18 post post VBP cord-023134-y665agnh 1367 19 - - RB cord-023134-y665agnh 1367 20 operatively operatively RB cord-023134-y665agnh 1367 21 once once RB cord-023134-y665agnh 1367 22 in in IN cord-023134-y665agnh 1367 23 a a DT cord-023134-y665agnh 1367 24 single single JJ cord-023134-y665agnh 1367 25 dog dog NN cord-023134-y665agnh 1367 26 . . . cord-023134-y665agnh 1368 1 No no DT cord-023134-y665agnh 1368 2 signs sign NNS cord-023134-y665agnh 1368 3 of of IN cord-023134-y665agnh 1368 4 stranguria stranguria NNP cord-023134-y665agnh 1368 5 or or CC cord-023134-y665agnh 1368 6 pollakiuria pollakiuria NNP cord-023134-y665agnh 1368 7 or or CC cord-023134-y665agnh 1368 8 incisional incisional JJ cord-023134-y665agnh 1368 9 complications complication NNS cord-023134-y665agnh 1368 10 were be VBD cord-023134-y665agnh 1368 11 identified identify VBN cord-023134-y665agnh 1368 12 in in IN cord-023134-y665agnh 1368 13 any any DT cord-023134-y665agnh 1368 14 of of IN cord-023134-y665agnh 1368 15 the the DT cord-023134-y665agnh 1368 16 9 9 CD cord-023134-y665agnh 1368 17 dogs dog NNS cord-023134-y665agnh 1368 18 post post NN cord-023134-y665agnh 1368 19 - - RB cord-023134-y665agnh 1368 20 operatively operatively RB cord-023134-y665agnh 1368 21 at at IN cord-023134-y665agnh 1368 22 follow follow NN cord-023134-y665agnh 1368 23 - - HYPH cord-023134-y665agnh 1368 24 up up NN cord-023134-y665agnh 1368 25 examination examination NN cord-023134-y665agnh 1368 26 or or CC cord-023134-y665agnh 1368 27 contact contact NN cord-023134-y665agnh 1368 28 ( ( -LRB- cord-023134-y665agnh 1368 29 range range NN cord-023134-y665agnh 1368 30 4 4 CD cord-023134-y665agnh 1368 31 to to IN cord-023134-y665agnh 1368 32 1248 1248 CD cord-023134-y665agnh 1368 33 days).The days).The NNP cord-023134-y665agnh 1368 34 percutaneous percutaneous JJ cord-023134-y665agnh 1368 35 perineal perineal NN cord-023134-y665agnh 1368 36 approach approach NN cord-023134-y665agnh 1368 37 in in IN cord-023134-y665agnh 1368 38 male male JJ cord-023134-y665agnh 1368 39 dogs dog NNS cord-023134-y665agnh 1368 40 for for IN cord-023134-y665agnh 1368 41 rigid rigid JJ cord-023134-y665agnh 1368 42 cystoscopy cystoscopy NN cord-023134-y665agnh 1368 43 appears appear VBZ cord-023134-y665agnh 1368 44 to to TO cord-023134-y665agnh 1368 45 be be VB cord-023134-y665agnh 1368 46 a a DT cord-023134-y665agnh 1368 47 safe safe JJ cord-023134-y665agnh 1368 48 and and CC cord-023134-y665agnh 1368 49 effective effective JJ cord-023134-y665agnh 1368 50 means mean NNS cord-023134-y665agnh 1368 51 of of IN cord-023134-y665agnh 1368 52 facilitating facilitate VBG cord-023134-y665agnh 1368 53 endoscopic endoscopic JJ cord-023134-y665agnh 1368 54 procedures procedure NNS cord-023134-y665agnh 1368 55 . . . cord-023134-y665agnh 1369 1 IRH IRH NNP cord-023134-y665agnh 1369 2 results result NNS cord-023134-y665agnh 1369 3 in in IN cord-023134-y665agnh 1369 4 chronic chronic JJ cord-023134-y665agnh 1369 5 upper upper JJ cord-023134-y665agnh 1369 6 urinary urinary JJ cord-023134-y665agnh 1369 7 tract tract NN cord-023134-y665agnh 1369 8 bleeding bleeding NN cord-023134-y665agnh 1369 9 . . . cord-023134-y665agnh 1370 1 In in IN cord-023134-y665agnh 1370 2 humans human NNS cord-023134-y665agnh 1370 3 , , , cord-023134-y665agnh 1370 4 ruptured rupture VBD cord-023134-y665agnh 1370 5 renal renal JJ cord-023134-y665agnh 1370 6 pelvic pelvic JJ cord-023134-y665agnh 1370 7 hemangiomas hemangiomas NNP cord-023134-y665agnh 1370 8 / / SYM cord-023134-y665agnh 1370 9 angiomas angioma NNS cord-023134-y665agnh 1370 10 are be VBP cord-023134-y665agnh 1370 11 typically typically RB cord-023134-y665agnh 1370 12 the the DT cord-023134-y665agnh 1370 13 cause cause NN cord-023134-y665agnh 1370 14 . . . cord-023134-y665agnh 1371 1 Although although IN cord-023134-y665agnh 1371 2 benign benign JJ cord-023134-y665agnh 1371 3 , , , cord-023134-y665agnh 1371 4 anemia anemia NN cord-023134-y665agnh 1371 5 , , , cord-023134-y665agnh 1371 6 ureteral ureteral JJ cord-023134-y665agnh 1371 7 and and CC cord-023134-y665agnh 1371 8 urethral urethral JJ cord-023134-y665agnh 1371 9 obstruction(s obstruction(s NNP cord-023134-y665agnh 1371 10 ) ) -RRB- cord-023134-y665agnh 1371 11 can can MD cord-023134-y665agnh 1371 12 ensue ensue VB cord-023134-y665agnh 1371 13 . . . cord-023134-y665agnh 1372 1 With with IN cord-023134-y665agnh 1372 2 the the DT cord-023134-y665agnh 1372 3 advent advent NN cord-023134-y665agnh 1372 4 of of IN cord-023134-y665agnh 1372 5 endourology endourology NN cord-023134-y665agnh 1372 6 renalsparing renalspare VBG cord-023134-y665agnh 1372 7 therapies therapy NNS cord-023134-y665agnh 1372 8 like like IN cord-023134-y665agnh 1372 9 ureteropyeloscopic ureteropyeloscopic NNP cord-023134-y665agnh 1372 10 - - HYPH cord-023134-y665agnh 1372 11 guided guide VBN cord-023134-y665agnh 1372 12 electrocautery electrocautery NN cord-023134-y665agnh 1372 13 or or CC cord-023134-y665agnh 1372 14 sclerotherapy sclerotherapy NNP cord-023134-y665agnh 1372 15 has have VBZ cord-023134-y665agnh 1372 16 replaced replace VBN cord-023134-y665agnh 1372 17 ureteronephrectomy ureteronephrectomy RB cord-023134-y665agnh 1372 18 . . . cord-023134-y665agnh 1373 1 The the DT cord-023134-y665agnh 1373 2 objective objective NN cord-023134-y665agnh 1373 3 is be VBZ cord-023134-y665agnh 1373 4 to to TO cord-023134-y665agnh 1373 5 describe describe VB cord-023134-y665agnh 1373 6 the the DT cord-023134-y665agnh 1373 7 use use NN cord-023134-y665agnh 1373 8 of of IN cord-023134-y665agnh 1373 9 endoscopic endoscopic NN cord-023134-y665agnh 1373 10 - - HYPH cord-023134-y665agnh 1373 11 fluoroscopic fluoroscopic NN cord-023134-y665agnh 1373 12 - - HYPH cord-023134-y665agnh 1373 13 guided guide VBN cord-023134-y665agnh 1373 14 sclerotherapy sclerotherapy NN cord-023134-y665agnh 1373 15 for for IN cord-023134-y665agnh 1373 16 the the DT cord-023134-y665agnh 1373 17 treatment treatment NN cord-023134-y665agnh 1373 18 of of IN cord-023134-y665agnh 1373 19 IRH IRH NNP cord-023134-y665agnh 1373 20 in in IN cord-023134-y665agnh 1373 21 dogs dog NNS cord-023134-y665agnh 1373 22 and and CC cord-023134-y665agnh 1373 23 report report VB cord-023134-y665agnh 1373 24 the the DT cord-023134-y665agnh 1373 25 first first JJ cord-023134-y665agnh 1373 26 clinical clinical JJ cord-023134-y665agnh 1373 27 outcomes outcome NNS cord-023134-y665agnh 1373 28 . . . cord-023134-y665agnh 1374 1 Each each DT cord-023134-y665agnh 1374 2 UVJ UVJ NNP cord-023134-y665agnh 1374 3 was be VBD cord-023134-y665agnh 1374 4 identified identify VBN cord-023134-y665agnh 1374 5 cystoscopically cystoscopically RB cord-023134-y665agnh 1374 6 . . . cord-023134-y665agnh 1375 1 Once once IN cord-023134-y665agnh 1375 2 the the DT cord-023134-y665agnh 1375 3 bleeding bleeding NN cord-023134-y665agnh 1375 4 was be VBD cord-023134-y665agnh 1375 5 confirmed confirm VBN cord-023134-y665agnh 1375 6 a a DT cord-023134-y665agnh 1375 7 retrograde retrograde JJ cord-023134-y665agnh 1375 8 ureteropyelogram ureteropyelogram NN cord-023134-y665agnh 1375 9 was be VBD cord-023134-y665agnh 1375 10 performed perform VBN cord-023134-y665agnh 1375 11 . . . cord-023134-y665agnh 1376 1 A a DT cord-023134-y665agnh 1376 2 ureteropelvic ureteropelvic JJ cord-023134-y665agnh 1376 3 junction junction NN cord-023134-y665agnh 1376 4 balloon balloon NN cord-023134-y665agnh 1376 5 was be VBD cord-023134-y665agnh 1376 6 used use VBN cord-023134-y665agnh 1376 7 for for IN cord-023134-y665agnh 1376 8 ureteral ureteral JJ cord-023134-y665agnh 1376 9 occlusion occlusion NN cord-023134-y665agnh 1376 10 and and CC cord-023134-y665agnh 1376 11 pelvis pelvi NNS cord-023134-y665agnh 1376 12 filling fill VBG cord-023134-y665agnh 1376 13 volumes volume NNS cord-023134-y665agnh 1376 14 were be VBD cord-023134-y665agnh 1376 15 recorded record VBN cord-023134-y665agnh 1376 16 . . . cord-023134-y665agnh 1377 1 Four four CD cord-023134-y665agnh 1377 2 dwells dwell NNS cord-023134-y665agnh 1377 3 were be VBD cord-023134-y665agnh 1377 4 performed perform VBN cord-023134-y665agnh 1377 5 ( ( -LRB- cord-023134-y665agnh 1377 6 2 2 CD cord-023134-y665agnh 1377 7 5 5 CD cord-023134-y665agnh 1377 8 % % NN cord-023134-y665agnh 1377 9 povidone povidone NN cord-023134-y665agnh 1377 10 iodine iodine NN cord-023134-y665agnh 1377 11 mixture mixture NN cord-023134-y665agnh 1377 12 ; ; : cord-023134-y665agnh 1377 13 and and CC cord-023134-y665agnh 1377 14 2 2 CD cord-023134-y665agnh 1377 15 sterile sterile JJ cord-023134-y665agnh 1377 16 liquid liquid JJ cord-023134-y665agnh 1377 17 0.5 0.5 CD cord-023134-y665agnh 1377 18 - - SYM cord-023134-y665agnh 1377 19 1 1 CD cord-023134-y665agnh 1377 20 % % NN cord-023134-y665agnh 1377 21 silver silver NN cord-023134-y665agnh 1377 22 nitrate nitrate NN cord-023134-y665agnh 1377 23 ) ) -RRB- cord-023134-y665agnh 1377 24 . . . cord-023134-y665agnh 1378 1 A a DT cord-023134-y665agnh 1378 2 double double JJ cord-023134-y665agnh 1378 3 - - HYPH cord-023134-y665agnh 1378 4 pigtail pigtail NN cord-023134-y665agnh 1378 5 ureteral ureteral JJ cord-023134-y665agnh 1378 6 stent stent NN cord-023134-y665agnh 1378 7 was be VBD cord-023134-y665agnh 1378 8 placed place VBN cord-023134-y665agnh 1378 9 . . . cord-023134-y665agnh 1379 1 Seven seven CD cord-023134-y665agnh 1379 2 dogs dog NNS cord-023134-y665agnh 1379 3 had have VBD cord-023134-y665agnh 1379 4 sclerotherapy sclerotherapy NN cord-023134-y665agnh 1379 5 . . . cord-023134-y665agnh 1380 1 Five five CD cord-023134-y665agnh 1380 2 unilateral unilateral JJ cord-023134-y665agnh 1380 3 , , , cord-023134-y665agnh 1380 4 1 1 CD cord-023134-y665agnh 1380 5 bilateral bilateral JJ cord-023134-y665agnh 1380 6 , , , cord-023134-y665agnh 1380 7 and and CC cord-023134-y665agnh 1380 8 1 1 CD cord-023134-y665agnh 1380 9 developed develop VBD cord-023134-y665agnh 1380 10 contralateral contralateral JJ cord-023134-y665agnh 1380 11 bleeding bleeding NN cord-023134-y665agnh 1380 12 ( ( -LRB- cord-023134-y665agnh 1380 13 n=9 n=9 JJ cord-023134-y665agnh 1380 14 units unit NNS cord-023134-y665agnh 1380 15 ) ) -RRB- cord-023134-y665agnh 1380 16 . . . cord-023134-y665agnh 1381 1 Five five CD cord-023134-y665agnh 1381 2 were be VBD cord-023134-y665agnh 1381 3 right right JJ cord-023134-y665agnh 1381 4 and and CC cord-023134-y665agnh 1381 5 4 4 CD cord-023134-y665agnh 1381 6 left left JJ cord-023134-y665agnh 1381 7 - - HYPH cord-023134-y665agnh 1381 8 sided sided JJ cord-023134-y665agnh 1381 9 . . . cord-023134-y665agnh 1382 1 There there EX cord-023134-y665agnh 1382 2 were be VBD cord-023134-y665agnh 1382 3 6 6 CD cord-023134-y665agnh 1382 4 males male NNS cord-023134-y665agnh 1382 5 and and CC cord-023134-y665agnh 1382 6 1 1 CD cord-023134-y665agnh 1382 7 female female NN cord-023134-y665agnh 1382 8 . . . cord-023134-y665agnh 1383 1 The the DT cord-023134-y665agnh 1383 2 median median JJ cord-023134-y665agnh 1383 3 age age NN cord-023134-y665agnh 1383 4 and and CC cord-023134-y665agnh 1383 5 weight weight NN cord-023134-y665agnh 1383 6 was be VBD cord-023134-y665agnh 1383 7 6 6 CD cord-023134-y665agnh 1383 8 years year NNS cord-023134-y665agnh 1383 9 and and CC cord-023134-y665agnh 1383 10 27.5 27.5 CD cord-023134-y665agnh 1383 11 kg kg NNS cord-023134-y665agnh 1383 12 , , , cord-023134-y665agnh 1383 13 respectively respectively RB cord-023134-y665agnh 1383 14 . . . cord-023134-y665agnh 1384 1 Median median JJ cord-023134-y665agnh 1384 2 procedure procedure NN cord-023134-y665agnh 1384 3 time time NN cord-023134-y665agnh 1384 4 was be VBD cord-023134-y665agnh 1384 5 150 150 CD cord-023134-y665agnh 1384 6 minutes minute NNS cord-023134-y665agnh 1384 7 . . . cord-023134-y665agnh 1385 1 There there EX cord-023134-y665agnh 1385 2 was be VBD cord-023134-y665agnh 1385 3 1 1 CD cord-023134-y665agnh 1385 4 complication complication NN cord-023134-y665agnh 1385 5 of of IN cord-023134-y665agnh 1385 6 severe severe JJ cord-023134-y665agnh 1385 7 renal renal JJ cord-023134-y665agnh 1385 8 discomfort discomfort NN cord-023134-y665agnh 1385 9 and and CC cord-023134-y665agnh 1385 10 pyelectasia pyelectasia NN cord-023134-y665agnh 1385 11 in in IN cord-023134-y665agnh 1385 12 an an DT cord-023134-y665agnh 1385 13 unstented unstented JJ cord-023134-y665agnh 1385 14 dog dog NN cord-023134-y665agnh 1385 15 . . . cord-023134-y665agnh 1386 1 Cessation cessation NN cord-023134-y665agnh 1386 2 of of IN cord-023134-y665agnh 1386 3 hematuria hematuria NN cord-023134-y665agnh 1386 4 occurred occur VBD cord-023134-y665agnh 1386 5 in in IN cord-023134-y665agnh 1386 6 6/9 6/9 CD cord-023134-y665agnh 1386 7 renal renal JJ cord-023134-y665agnh 1386 8 units unit NNS cord-023134-y665agnh 1386 9 ( ( -LRB- cord-023134-y665agnh 1386 10 median median JJ cord-023134-y665agnh 1386 11 12 12 CD cord-023134-y665agnh 1386 12 hours hour NNS cord-023134-y665agnh 1386 13 ) ) -RRB- cord-023134-y665agnh 1386 14 . . . cord-023134-y665agnh 1387 1 Two two CD cord-023134-y665agnh 1387 2 had have VBD cord-023134-y665agnh 1387 3 recurrence recurrence NN cord-023134-y665agnh 1387 4 within within IN cord-023134-y665agnh 1387 5 3 3 CD cord-023134-y665agnh 1387 6 weeks week NNS cord-023134-y665agnh 1387 7 ; ; : cord-023134-y665agnh 1387 8 both both DT cord-023134-y665agnh 1387 9 resorted resort VBD cord-023134-y665agnh 1387 10 to to IN cord-023134-y665agnh 1387 11 intermittent intermittent JJ cord-023134-y665agnh 1387 12 mild mild JJ cord-023134-y665agnh 1387 13 hematuria hematuria NN cord-023134-y665agnh 1387 14 . . . cord-023134-y665agnh 1388 1 Two two CD cord-023134-y665agnh 1388 2 failed fail VBN cord-023134-y665agnh 1388 3 treatment treatment NN cord-023134-y665agnh 1388 4 . . . cord-023134-y665agnh 1389 1 Median median JJ cord-023134-y665agnh 1389 2 follow follow NN cord-023134-y665agnh 1389 3 - - HYPH cord-023134-y665agnh 1389 4 up up RP cord-023134-y665agnh 1389 5 time time NN cord-023134-y665agnh 1389 6 was be VBD cord-023134-y665agnh 1389 7 5 5 CD cord-023134-y665agnh 1389 8 months month NNS cord-023134-y665agnh 1389 9 ( ( -LRB- cord-023134-y665agnh 1389 10 range range NN cord-023134-y665agnh 1389 11 , , , cord-023134-y665agnh 1389 12 1.5 1.5 CD cord-023134-y665agnh 1389 13 - - SYM cord-023134-y665agnh 1389 14 19 19 CD cord-023134-y665agnh 1389 15 ) ) -RRB- cord-023134-y665agnh 1389 16 .Overall .Overall NFP cord-023134-y665agnh 1389 17 , , , cord-023134-y665agnh 1389 18 topical topical JJ cord-023134-y665agnh 1389 19 sclerotherapy sclerotherapy NN cord-023134-y665agnh 1389 20 for for IN cord-023134-y665agnh 1389 21 IRH IRH NNP cord-023134-y665agnh 1389 22 can can MD cord-023134-y665agnh 1389 23 be be VB cord-023134-y665agnh 1389 24 safe safe JJ cord-023134-y665agnh 1389 25 and and CC cord-023134-y665agnh 1389 26 effective effective JJ cord-023134-y665agnh 1389 27 . . . cord-023134-y665agnh 1390 1 This this DT cord-023134-y665agnh 1390 2 is be VBZ cord-023134-y665agnh 1390 3 the the DT cord-023134-y665agnh 1390 4 first first JJ cord-023134-y665agnh 1390 5 report report NN cord-023134-y665agnh 1390 6 of of IN cord-023134-y665agnh 1390 7 local local JJ cord-023134-y665agnh 1390 8 sclerotherapy sclerotherapy NN cord-023134-y665agnh 1390 9 for for IN cord-023134-y665agnh 1390 10 IRH IRH NNP cord-023134-y665agnh 1390 11 in in IN cord-023134-y665agnh 1390 12 dogs dog NNS cord-023134-y665agnh 1390 13 and and CC cord-023134-y665agnh 1390 14 could could MD cord-023134-y665agnh 1390 15 be be VB cord-023134-y665agnh 1390 16 considered consider VBN cord-023134-y665agnh 1390 17 a a DT cord-023134-y665agnh 1390 18 valuable valuable JJ cord-023134-y665agnh 1390 19 endoscopic endoscopic NN cord-023134-y665agnh 1390 20 - - HYPH cord-023134-y665agnh 1390 21 guided guide VBN cord-023134-y665agnh 1390 22 therapy therapy NN cord-023134-y665agnh 1390 23 prior prior RB cord-023134-y665agnh 1390 24 to to IN cord-023134-y665agnh 1390 25 ureteronephrectomy ureteronephrectomy NN cord-023134-y665agnh 1390 26 . . . cord-023134-y665agnh 1391 1 Further further JJ cord-023134-y665agnh 1391 2 investigation investigation NN cord-023134-y665agnh 1391 3 is be VBZ cord-023134-y665agnh 1391 4 required require VBN cord-023134-y665agnh 1391 5 . . . cord-023134-y665agnh 1392 1 Percutaneous Percutaneous NNP cord-023134-y665agnh 1392 2 nephrolithotomy nephrolithotomy RB cord-023134-y665agnh 1392 3 ( ( -LRB- cord-023134-y665agnh 1392 4 PCNL PCNL NNP cord-023134-y665agnh 1392 5 ) ) -RRB- cord-023134-y665agnh 1392 6 is be VBZ cord-023134-y665agnh 1392 7 considered consider VBN cord-023134-y665agnh 1392 8 the the DT cord-023134-y665agnh 1392 9 standard standard JJ cord-023134-y665agnh 1392 10 -of -of ADD cord-023134-y665agnh 1392 11 - - HYPH cord-023134-y665agnh 1392 12 care care NN cord-023134-y665agnh 1392 13 for for IN cord-023134-y665agnh 1392 14 removal removal NN cord-023134-y665agnh 1392 15 of of IN cord-023134-y665agnh 1392 16 nephroliths nephrolith NNS cord-023134-y665agnh 1393 1 > > XX cord-023134-y665agnh 1394 1 1.5 1.5 CD cord-023134-y665agnh 1394 2 cm cm NNS cord-023134-y665agnh 1394 3 in in IN cord-023134-y665agnh 1394 4 people people NNS cord-023134-y665agnh 1394 5 , , , cord-023134-y665agnh 1394 6 minimizing minimize VBG cord-023134-y665agnh 1394 7 morbidity morbidity NN cord-023134-y665agnh 1394 8 and and CC cord-023134-y665agnh 1394 9 preserving preserve VBG cord-023134-y665agnh 1394 10 renal renal JJ cord-023134-y665agnh 1394 11 function function NN cord-023134-y665agnh 1394 12 . . . cord-023134-y665agnh 1395 1 Success success NN cord-023134-y665agnh 1395 2 rates rate NNS cord-023134-y665agnh 1395 3 are be VBP cord-023134-y665agnh 1395 4 reported report VBN cord-023134-y665agnh 1395 5 to to TO cord-023134-y665agnh 1395 6 be be VB cord-023134-y665agnh 1395 7 90 90 CD cord-023134-y665agnh 1395 8 - - SYM cord-023134-y665agnh 1395 9 100 100 CD cord-023134-y665agnh 1395 10 % % NN cord-023134-y665agnh 1395 11 . . . cord-023134-y665agnh 1396 1 Most Most JJS cord-023134-y665agnh 1396 2 veterinary veterinary JJ cord-023134-y665agnh 1396 3 nephroliths nephrolith NNS cord-023134-y665agnh 1396 4 remain remain VBP cord-023134-y665agnh 1396 5 clinically clinically RB cord-023134-y665agnh 1396 6 silent silent JJ cord-023134-y665agnh 1396 7 and and CC cord-023134-y665agnh 1396 8 removal removal NN cord-023134-y665agnh 1396 9 is be VBZ cord-023134-y665agnh 1396 10 only only RB cord-023134-y665agnh 1396 11 recommended recommend VBN cord-023134-y665agnh 1396 12 for for IN cord-023134-y665agnh 1396 13 complicated complicated JJ cord-023134-y665agnh 1396 14 stones stone NNS cord-023134-y665agnh 1396 15 . . . cord-023134-y665agnh 1397 1 Morbidity morbidity NN cord-023134-y665agnh 1397 2 of of IN cord-023134-y665agnh 1397 3 nephrotomy nephrotomy NNP cord-023134-y665agnh 1397 4 can can MD cord-023134-y665agnh 1397 5 be be VB cord-023134-y665agnh 1397 6 severe severe JJ cord-023134-y665agnh 1397 7 . . . cord-023134-y665agnh 1398 1 The the DT cord-023134-y665agnh 1398 2 objective objective NN cord-023134-y665agnh 1398 3 is be VBZ cord-023134-y665agnh 1398 4 to to TO cord-023134-y665agnh 1398 5 describe describe VB cord-023134-y665agnh 1398 6 endoscopic endoscopic NNS cord-023134-y665agnh 1398 7 - - HYPH cord-023134-y665agnh 1398 8 guided guide VBN cord-023134-y665agnh 1398 9 nephrolithotomy nephrolithotomy NN cord-023134-y665agnh 1398 10 ( ( -LRB- cord-023134-y665agnh 1398 11 ENL ENL NNP cord-023134-y665agnh 1398 12 ) ) -RRB- cord-023134-y665agnh 1398 13 in in IN cord-023134-y665agnh 1398 14 canine canine JJ cord-023134-y665agnh 1398 15 and and CC cord-023134-y665agnh 1398 16 feline feline JJ cord-023134-y665agnh 1398 17 patients patient NNS cord-023134-y665agnh 1398 18 and and CC cord-023134-y665agnh 1398 19 report report VB cord-023134-y665agnh 1398 20 clinical clinical JJ cord-023134-y665agnh 1398 21 outcomes outcome NNS cord-023134-y665agnh 1398 22 , , , cord-023134-y665agnh 1398 23 hypothesizing hypothesize VBG cord-023134-y665agnh 1398 24 it -PRON- PRP cord-023134-y665agnh 1398 25 is be VBZ cord-023134-y665agnh 1398 26 safe safe JJ cord-023134-y665agnh 1398 27 and and CC cord-023134-y665agnh 1398 28 effective effective JJ cord-023134-y665agnh 1398 29 . . . cord-023134-y665agnh 1399 1 Patients patient NNS cord-023134-y665agnh 1399 2 that that WDT cord-023134-y665agnh 1399 3 had have VBD cord-023134-y665agnh 1399 4 either either CC cord-023134-y665agnh 1399 5 PCNL PCNL NNP cord-023134-y665agnh 1399 6 or or CC cord-023134-y665agnh 1399 7 surgicallyassisted surgicallyassiste VBN cord-023134-y665agnh 1399 8 endoscopic endoscopic NNS cord-023134-y665agnh 1399 9 nephrolithotomy nephrolithotomy NN cord-023134-y665agnh 1399 10 ( ( -LRB- cord-023134-y665agnh 1399 11 SENL SENL NNP cord-023134-y665agnh 1399 12 ) ) -RRB- cord-023134-y665agnh 1399 13 were be VBD cord-023134-y665agnh 1399 14 retrospectively retrospectively RB cord-023134-y665agnh 1399 15 evaluated evaluate VBN cord-023134-y665agnh 1399 16 . . . cord-023134-y665agnh 1400 1 A a DT cord-023134-y665agnh 1400 2 renal renal JJ cord-023134-y665agnh 1400 3 puncture puncture NN cord-023134-y665agnh 1400 4 needle needle NN cord-023134-y665agnh 1400 5 and and CC cord-023134-y665agnh 1400 6 balloon balloon NN cord-023134-y665agnh 1400 7 - - HYPH cord-023134-y665agnh 1400 8 dilation dilation NN cord-023134-y665agnh 1400 9 - - HYPH cord-023134-y665agnh 1400 10 sheath sheath NN cord-023134-y665agnh 1400 11 combination combination NN cord-023134-y665agnh 1400 12 was be VBD cord-023134-y665agnh 1400 13 used use VBN cord-023134-y665agnh 1400 14 for for IN cord-023134-y665agnh 1400 15 tract tract NN cord-023134-y665agnh 1400 16 formation formation NN cord-023134-y665agnh 1400 17 . . . cord-023134-y665agnh 1401 1 A a DT cord-023134-y665agnh 1401 2 nephroscope nephroscope NN cord-023134-y665agnh 1401 3 provided provide VBD cord-023134-y665agnh 1401 4 visualization visualization NN cord-023134-y665agnh 1401 5 for for IN cord-023134-y665agnh 1401 6 intracorporeal intracorporeal NN cord-023134-y665agnh 1401 7 lithotripsy lithotripsy NN cord-023134-y665agnh 1401 8 . . . cord-023134-y665agnh 1402 1 Stone stone NN cord-023134-y665agnh 1402 2 fragments fragment NNS cord-023134-y665agnh 1402 3 were be VBD cord-023134-y665agnh 1402 4 removed remove VBN cord-023134-y665agnh 1402 5 and and CC cord-023134-y665agnh 1402 6 a a DT cord-023134-y665agnh 1402 7 ureteral ureteral JJ cord-023134-y665agnh 1402 8 stent stent NN cord-023134-y665agnh 1402 9 was be VBD cord-023134-y665agnh 1402 10 placed place VBN cord-023134-y665agnh 1402 11 . . . cord-023134-y665agnh 1403 1 Nine nine CD cord-023134-y665agnh 1403 2 dogs dog NNS cord-023134-y665agnh 1403 3 and and CC cord-023134-y665agnh 1403 4 1 1 CD cord-023134-y665agnh 1403 5 cat cat NN cord-023134-y665agnh 1403 6 ( ( -LRB- cord-023134-y665agnh 1403 7 12 12 CD cord-023134-y665agnh 1403 8 renal renal JJ cord-023134-y665agnh 1403 9 units unit NNS cord-023134-y665agnh 1403 10 ) ) -RRB- cord-023134-y665agnh 1403 11 were be VBD cord-023134-y665agnh 1403 12 included include VBN cord-023134-y665agnh 1403 13 . . . cord-023134-y665agnh 1404 1 Four four CD cord-023134-y665agnh 1404 2 had have VBD cord-023134-y665agnh 1404 3 PCNL PCNL NNS cord-023134-y665agnh 1404 4 and and CC cord-023134-y665agnh 1404 5 6 6 CD cord-023134-y665agnh 1404 6 SENL SENL NNP cord-023134-y665agnh 1404 7 . . . cord-023134-y665agnh 1405 1 Indications indication NNS cord-023134-y665agnh 1405 2 included include VBD cord-023134-y665agnh 1405 3 recurrent recurrent JJ cord-023134-y665agnh 1405 4 UTIs uti NNS cord-023134-y665agnh 1405 5 ( ( -LRB- cord-023134-y665agnh 1405 6 4 4 CD cord-023134-y665agnh 1405 7 ) ) -RRB- cord-023134-y665agnh 1405 8 , , , cord-023134-y665agnh 1405 9 worsening worsen VBG cord-023134-y665agnh 1405 10 azotemia azotemia NN cord-023134-y665agnh 1405 11 ( ( -LRB- cord-023134-y665agnh 1405 12 4 4 CD cord-023134-y665agnh 1405 13 ) ) -RRB- cord-023134-y665agnh 1405 14 , , , cord-023134-y665agnh 1405 15 and and CC cord-023134-y665agnh 1405 16 ureteral ureteral JJ cord-023134-y665agnh 1405 17 - - HYPH cord-023134-y665agnh 1405 18 outflow outflow NN cord-023134-y665agnh 1405 19 obstructions obstruction NNS cord-023134-y665agnh 1405 20 ( ( -LRB- cord-023134-y665agnh 1405 21 2 2 CD cord-023134-y665agnh 1405 22 ) ) -RRB- cord-023134-y665agnh 1405 23 . . . cord-023134-y665agnh 1406 1 Median median JJ cord-023134-y665agnh 1406 2 weight weight NN cord-023134-y665agnh 1406 3 was be VBD cord-023134-y665agnh 1406 4 8.2 8.2 CD cord-023134-y665agnh 1406 5 kg kg NNS cord-023134-y665agnh 1406 6 ( ( -LRB- cord-023134-y665agnh 1406 7 3 3 CD cord-023134-y665agnh 1406 8 . . . cord-023134-y665agnh 1406 9 1 1 CD cord-023134-y665agnh 1406 10 - - CD cord-023134-y665agnh 1406 11 26.9 26.9 CD cord-023134-y665agnh 1406 12 ) ) -RRB- cord-023134-y665agnh 1406 13 . . . cord-023134-y665agnh 1407 1 Stone stone NN cord-023134-y665agnh 1407 2 composition composition NN cord-023134-y665agnh 1407 3 was be VBD cord-023134-y665agnh 1407 4 calcium calcium NN cord-023134-y665agnh 1407 5 oxalate oxalate NN cord-023134-y665agnh 1407 6 ( ( -LRB- cord-023134-y665agnh 1407 7 6 6 CD cord-023134-y665agnh 1407 8 ) ) -RRB- cord-023134-y665agnh 1407 9 , , , cord-023134-y665agnh 1407 10 mixed mix VBN cord-023134-y665agnh 1407 11 struvite struvite NN cord-023134-y665agnh 1407 12 ( ( -LRB- cord-023134-y665agnh 1407 13 2 2 CD cord-023134-y665agnh 1407 14 ) ) -RRB- cord-023134-y665agnh 1407 15 , , , cord-023134-y665agnh 1407 16 urate urate NN cord-023134-y665agnh 1407 17 ( ( -LRB- cord-023134-y665agnh 1407 18 1 1 CD cord-023134-y665agnh 1407 19 ) ) -RRB- cord-023134-y665agnh 1407 20 , , , cord-023134-y665agnh 1407 21 and and CC cord-023134-y665agnh 1407 22 cystine cystine NN cord-023134-y665agnh 1407 23 ( ( -LRB- cord-023134-y665agnh 1407 24 1 1 CD cord-023134-y665agnh 1407 25 ) ) -RRB- cord-023134-y665agnh 1407 26 . . . cord-023134-y665agnh 1408 1 Median median JJ cord-023134-y665agnh 1408 2 stone stone NN cord-023134-y665agnh 1408 3 size size NN cord-023134-y665agnh 1408 4 was be VBD cord-023134-y665agnh 1408 5 2 2 CD cord-023134-y665agnh 1408 6 cm cm NNS cord-023134-y665agnh 1408 7 ( ( -LRB- cord-023134-y665agnh 1408 8 0.7 0.7 CD cord-023134-y665agnh 1408 9 - - SYM cord-023134-y665agnh 1408 10 5 5 CD cord-023134-y665agnh 1408 11 ) ) -RRB- cord-023134-y665agnh 1408 12 . . . cord-023134-y665agnh 1409 1 Median median JJ cord-023134-y665agnh 1409 2 pre pre JJ cord-023134-y665agnh 1409 3 - - NN cord-023134-y665agnh 1409 4 and and CC cord-023134-y665agnh 1409 5 3 3 CD cord-023134-y665agnh 1409 6 month month NN cord-023134-y665agnh 1409 7 post post JJ cord-023134-y665agnh 1409 8 - - JJ cord-023134-y665agnh 1409 9 operative operative JJ cord-023134-y665agnh 1409 10 creatinine creatinine NN cord-023134-y665agnh 1409 11 was be VBD cord-023134-y665agnh 1409 12 1.3 1.3 CD cord-023134-y665agnh 1409 13 ( ( -LRB- cord-023134-y665agnh 1409 14 0.8 0.8 CD cord-023134-y665agnh 1409 15 - - SYM cord-023134-y665agnh 1409 16 9.1 9.1 CD cord-023134-y665agnh 1409 17 ) ) -RRB- cord-023134-y665agnh 1409 18 and and CC cord-023134-y665agnh 1409 19 1.1 1.1 CD cord-023134-y665agnh 1409 20 mg mg NN cord-023134-y665agnh 1409 21 / / SYM cord-023134-y665agnh 1409 22 dL dl NN cord-023134-y665agnh 1409 23 ( ( -LRB- cord-023134-y665agnh 1409 24 0.6 0.6 CD cord-023134-y665agnh 1409 25 - - SYM cord-023134-y665agnh 1409 26 6.1 6.1 CD cord-023134-y665agnh 1409 27 ) ) -RRB- cord-023134-y665agnh 1409 28 , , , cord-023134-y665agnh 1409 29 respectively respectively RB cord-023134-y665agnh 1409 30 . . . cord-023134-y665agnh 1410 1 The the DT cord-023134-y665agnh 1410 2 median median JJ cord-023134-y665agnh 1410 3 procedure procedure NN cord-023134-y665agnh 1410 4 time time NN cord-023134-y665agnh 1410 5 was be VBD cord-023134-y665agnh 1410 6 165 165 CD cord-023134-y665agnh 1410 7 minutes minute NNS cord-023134-y665agnh 1410 8 . . . cord-023134-y665agnh 1411 1 Successful successful JJ cord-023134-y665agnh 1411 2 removal removal NN cord-023134-y665agnh 1411 3 of of IN cord-023134-y665agnh 1411 4 all all DT cord-023134-y665agnh 1411 5 stones stone NNS cord-023134-y665agnh 1411 6 were be VBD cord-023134-y665agnh 1411 7 documented document VBN cord-023134-y665agnh 1411 8 in in IN cord-023134-y665agnh 1411 9 11/12 11/12 CD cord-023134-y665agnh 1411 10 ( ( -LRB- cord-023134-y665agnh 1411 11 91.6 91.6 CD cord-023134-y665agnh 1411 12 % % NN cord-023134-y665agnh 1411 13 ) ) -RRB- cord-023134-y665agnh 1411 14 . . . cord-023134-y665agnh 1412 1 Procedure procedure NN cord-023134-y665agnh 1412 2 - - HYPH cord-023134-y665agnh 1412 3 related relate VBN cord-023134-y665agnh 1412 4 complications complication NNS cord-023134-y665agnh 1412 5 occurred occur VBD cord-023134-y665agnh 1412 6 in in IN cord-023134-y665agnh 1412 7 3 3 CD cord-023134-y665agnh 1412 8 units unit NNS cord-023134-y665agnh 1412 9 , , , cord-023134-y665agnh 1412 10 all all DT cord-023134-y665agnh 1412 11 were be VBD cord-023134-y665agnh 1412 12 easily easily RB cord-023134-y665agnh 1412 13 managed manage VBN cord-023134-y665agnh 1412 14 . . . cord-023134-y665agnh 1413 1 Median median JJ cord-023134-y665agnh 1413 2 follow follow NN cord-023134-y665agnh 1413 3 - - HYPH cord-023134-y665agnh 1413 4 up up RP cord-023134-y665agnh 1413 5 time time NN cord-023134-y665agnh 1413 6 was be VBD cord-023134-y665agnh 1413 7 150 150 CD cord-023134-y665agnh 1413 8 days day NNS cord-023134-y665agnh 1413 9 ( ( -LRB- cord-023134-y665agnh 1413 10 4 4 CD cord-023134-y665agnh 1413 11 - - SYM cord-023134-y665agnh 1413 12 2007 2007 CD cord-023134-y665agnh 1413 13 ) ) -RRB- cord-023134-y665agnh 1413 14 . . . cord-023134-y665agnh 1414 1 Four four CD cord-023134-y665agnh 1414 2 patients patient NNS cord-023134-y665agnh 1414 3 are be VBP cord-023134-y665agnh 1414 4 still still RB cord-023134-y665agnh 1414 5 alive alive JJ cord-023134-y665agnh 1414 6 . . . cord-023134-y665agnh 1415 1 No no DT cord-023134-y665agnh 1415 2 patient patient NN cord-023134-y665agnh 1415 3 died die VBD cord-023134-y665agnh 1415 4 from from IN cord-023134-y665agnh 1415 5 the the DT cord-023134-y665agnh 1415 6 procedure procedure NN cord-023134-y665agnh 1415 7 . . . cord-023134-y665agnh 1416 1 Overall overall RB cord-023134-y665agnh 1416 2 , , , cord-023134-y665agnh 1416 3 ENL ENL NNP cord-023134-y665agnh 1416 4 can can MD cord-023134-y665agnh 1416 5 be be VB cord-023134-y665agnh 1416 6 safely safely RB cord-023134-y665agnh 1416 7 performed perform VBN cord-023134-y665agnh 1416 8 in in IN cord-023134-y665agnh 1416 9 dogs dog NNS cord-023134-y665agnh 1416 10 and and CC cord-023134-y665agnh 1416 11 cats cat NNS cord-023134-y665agnh 1416 12 , , , cord-023134-y665agnh 1416 13 yielding yield VBG cord-023134-y665agnh 1416 14 similar similar JJ cord-023134-y665agnh 1416 15 success success NN cord-023134-y665agnh 1416 16 rates rate NNS cord-023134-y665agnh 1416 17 to to IN cord-023134-y665agnh 1416 18 people people NNS cord-023134-y665agnh 1416 19 . . . cord-023134-y665agnh 1417 1 Advanced advanced JJ cord-023134-y665agnh 1417 2 endourologic endourologic JJ cord-023134-y665agnh 1417 3 experience experience NN cord-023134-y665agnh 1417 4 is be VBZ cord-023134-y665agnh 1417 5 recommended recommend VBN cord-023134-y665agnh 1417 6 . . . cord-023134-y665agnh 1418 1 FGF-23 FGF-23 NNP cord-023134-y665agnh 1418 2 is be VBZ cord-023134-y665agnh 1418 3 a a DT cord-023134-y665agnh 1418 4 key key JJ cord-023134-y665agnh 1418 5 regulator regulator NN cord-023134-y665agnh 1418 6 of of IN cord-023134-y665agnh 1418 7 plasma plasma NN cord-023134-y665agnh 1418 8 phosphate phosphate NN cord-023134-y665agnh 1418 9 concentration concentration NN cord-023134-y665agnh 1418 10 . . . cord-023134-y665agnh 1419 1 It -PRON- PRP cord-023134-y665agnh 1419 2 is be VBZ cord-023134-y665agnh 1419 3 elevated elevate VBN cord-023134-y665agnh 1419 4 in in IN cord-023134-y665agnh 1419 5 cats cat NNS cord-023134-y665agnh 1419 6 with with IN cord-023134-y665agnh 1419 7 naturally naturally RB cord-023134-y665agnh 1419 8 occurring occur VBG cord-023134-y665agnh 1419 9 CKD CKD NNP cord-023134-y665agnh 1419 10 and and CC cord-023134-y665agnh 1419 11 increases increase VBZ cord-023134-y665agnh 1419 12 as as IN cord-023134-y665agnh 1419 13 renal renal JJ cord-023134-y665agnh 1419 14 function function NN cord-023134-y665agnh 1419 15 declines decline NNS cord-023134-y665agnh 1419 16 . . . cord-023134-y665agnh 1420 1 Elevated elevated JJ cord-023134-y665agnh 1420 2 FGF-23 FGF-23 NNP cord-023134-y665agnh 1420 3 concentrations concentration NNS cord-023134-y665agnh 1420 4 are be VBP cord-023134-y665agnh 1420 5 an an DT cord-023134-y665agnh 1420 6 independent independent JJ cord-023134-y665agnh 1420 7 predictor predictor NN cord-023134-y665agnh 1420 8 of of IN cord-023134-y665agnh 1420 9 survival survival NN cord-023134-y665agnh 1420 10 time time NN cord-023134-y665agnh 1420 11 in in IN cord-023134-y665agnh 1420 12 human human JJ cord-023134-y665agnh 1420 13 haemodialysis haemodialysis NNP cord-023134-y665agnh 1420 14 patients patient NNS cord-023134-y665agnh 1420 15 , , , cord-023134-y665agnh 1420 16 but but CC cord-023134-y665agnh 1420 17 this this DT cord-023134-y665agnh 1420 18 association association NN cord-023134-y665agnh 1420 19 has have VBZ cord-023134-y665agnh 1420 20 not not RB cord-023134-y665agnh 1420 21 previously previously RB cord-023134-y665agnh 1420 22 been be VBN cord-023134-y665agnh 1420 23 examined examine VBN cord-023134-y665agnh 1420 24 in in IN cord-023134-y665agnh 1420 25 cats cat NNS cord-023134-y665agnh 1420 26 with with IN cord-023134-y665agnh 1420 27 CKD CKD NNP cord-023134-y665agnh 1420 28 . . . cord-023134-y665agnh 1421 1 This this DT cord-023134-y665agnh 1421 2 study study NN cord-023134-y665agnh 1421 3 investigated investigate VBD cord-023134-y665agnh 1421 4 if if IN cord-023134-y665agnh 1421 5 FGF-23 FGF-23 NNP cord-023134-y665agnh 1421 6 was be VBD cord-023134-y665agnh 1421 7 independently independently RB cord-023134-y665agnh 1421 8 associated associate VBN cord-023134-y665agnh 1421 9 with with IN cord-023134-y665agnh 1421 10 survival survival NN cord-023134-y665agnh 1421 11 time time NN cord-023134-y665agnh 1421 12 ( ( -LRB- cord-023134-y665agnh 1421 13 all all DT cord-023134-y665agnh 1421 14 cause cause VBP cord-023134-y665agnh 1421 15 mortality mortality NN cord-023134-y665agnh 1421 16 ) ) -RRB- cord-023134-y665agnh 1421 17 in in IN cord-023134-y665agnh 1421 18 cats cat NNS cord-023134-y665agnh 1421 19 with with IN cord-023134-y665agnh 1421 20 newly newly RB cord-023134-y665agnh 1421 21 diagnosed diagnose VBN cord-023134-y665agnh 1421 22 CKD.Cats ckd.cat NNS cord-023134-y665agnh 1421 23 diagnosed diagnose VBN cord-023134-y665agnh 1421 24 with with IN cord-023134-y665agnh 1421 25 CKD CKD NNP cord-023134-y665agnh 1421 26 at at IN cord-023134-y665agnh 1421 27 two two CD cord-023134-y665agnh 1421 28 London London NNP cord-023134-y665agnh 1421 29 - - HYPH cord-023134-y665agnh 1421 30 based base VBN cord-023134-y665agnh 1421 31 first first JJ cord-023134-y665agnh 1421 32 opinion opinion NN cord-023134-y665agnh 1421 33 practices practice NNS cord-023134-y665agnh 1421 34 between between IN cord-023134-y665agnh 1421 35 2000 2000 CD cord-023134-y665agnh 1421 36 and and CC cord-023134-y665agnh 1421 37 2011 2011 CD cord-023134-y665agnh 1421 38 were be VBD cord-023134-y665agnh 1421 39 identified identify VBN cord-023134-y665agnh 1421 40 . . . cord-023134-y665agnh 1422 1 CKD CKD NNP cord-023134-y665agnh 1422 2 was be VBD cord-023134-y665agnh 1422 3 defined define VBN cord-023134-y665agnh 1422 4 as as IN cord-023134-y665agnh 1422 5 plasma plasma NN cord-023134-y665agnh 1422 6 creatinine creatinine NN cord-023134-y665agnh 1422 7 concentration concentration NN cord-023134-y665agnh 1422 8 > > XX cord-023134-y665agnh 1423 1 177lmol 177lmol NNP cord-023134-y665agnh 1423 2 / / SYM cord-023134-y665agnh 1423 3 l l NN cord-023134-y665agnh 1423 4 with with IN cord-023134-y665agnh 1423 5 concurrent concurrent JJ cord-023134-y665agnh 1423 6 urine urine NN cord-023134-y665agnh 1423 7 specific specific JJ cord-023134-y665agnh 1423 8 gravity gravity NN cord-023134-y665agnh 1423 9 ( ( -LRB- cord-023134-y665agnh 1423 10 USG USG NNP cord-023134-y665agnh 1423 11 ) ) -RRB- cord-023134-y665agnh 1423 12 < < XX cord-023134-y665agnh 1423 13 1.035 1.035 CD cord-023134-y665agnh 1423 14 or or CC cord-023134-y665agnh 1423 15 plasma plasma NN cord-023134-y665agnh 1423 16 creatinine creatinine NN cord-023134-y665agnh 1423 17 concentration concentration NN cord-023134-y665agnh 1424 1 > > XX cord-023134-y665agnh 1425 1 177lmol 177lmol NNP cord-023134-y665agnh 1425 2 / / SYM cord-023134-y665agnh 1425 3 l l NN cord-023134-y665agnh 1425 4 on on IN cord-023134-y665agnh 1425 5 two two CD cord-023134-y665agnh 1425 6 consecutive consecutive JJ cord-023134-y665agnh 1425 7 visits visit NNS cord-023134-y665agnh 1425 8 . . . cord-023134-y665agnh 1426 1 Cats cat NNS cord-023134-y665agnh 1426 2 were be VBD cord-023134-y665agnh 1426 3 excluded exclude VBN cord-023134-y665agnh 1426 4 if if IN cord-023134-y665agnh 1426 5 no no DT cord-023134-y665agnh 1426 6 residual residual JJ cord-023134-y665agnh 1426 7 EDTA edta NN cord-023134-y665agnh 1426 8 plasma plasma NN cord-023134-y665agnh 1426 9 was be VBD cord-023134-y665agnh 1426 10 available available JJ cord-023134-y665agnh 1426 11 to to TO cord-023134-y665agnh 1426 12 measure measure VB cord-023134-y665agnh 1426 13 plasma plasma NN cord-023134-y665agnh 1426 14 FGF-23 FGF-23 NNP cord-023134-y665agnh 1426 15 concentration concentration NN cord-023134-y665agnh 1426 16 within within IN cord-023134-y665agnh 1426 17 42 42 CD cord-023134-y665agnh 1426 18 days day NNS cord-023134-y665agnh 1426 19 of of IN cord-023134-y665agnh 1426 20 the the DT cord-023134-y665agnh 1426 21 date date NN cord-023134-y665agnh 1426 22 of of IN cord-023134-y665agnh 1426 23 diagnosis diagnosis NN cord-023134-y665agnh 1426 24 of of IN cord-023134-y665agnh 1426 25 CKD CKD NNP cord-023134-y665agnh 1426 26 . . . cord-023134-y665agnh 1427 1 FGF-23 FGF-23 NNP cord-023134-y665agnh 1427 2 concentrations concentration NNS cord-023134-y665agnh 1427 3 were be VBD cord-023134-y665agnh 1427 4 measured measure VBN cord-023134-y665agnh 1427 5 using use VBG cord-023134-y665agnh 1427 6 a a DT cord-023134-y665agnh 1427 7 previously previously RB cord-023134-y665agnh 1427 8 validated validate VBN cord-023134-y665agnh 1427 9 human human JJ cord-023134-y665agnh 1427 10 intact intact JJ cord-023134-y665agnh 1427 11 FGF-23 FGF-23 NNP cord-023134-y665agnh 1427 12 ELISA ELISA NNP cord-023134-y665agnh 1427 13 . . . cord-023134-y665agnh 1428 1 Plasma plasma NN cord-023134-y665agnh 1428 2 FGF-23 FGF-23 NNP cord-023134-y665agnh 1428 3 , , , cord-023134-y665agnh 1428 4 creatinine creatinine NN cord-023134-y665agnh 1428 5 , , , cord-023134-y665agnh 1428 6 phosphate phosphate NN cord-023134-y665agnh 1428 7 and and CC cord-023134-y665agnh 1428 8 total total JJ cord-023134-y665agnh 1428 9 calcium calcium NN cord-023134-y665agnh 1428 10 concentrations concentration NNS cord-023134-y665agnh 1428 11 , , , cord-023134-y665agnh 1428 12 packed pack VBN cord-023134-y665agnh 1428 13 cell cell NN cord-023134-y665agnh 1428 14 volume volume NN cord-023134-y665agnh 1428 15 ( ( -LRB- cord-023134-y665agnh 1428 16 PCV PCV NNP cord-023134-y665agnh 1428 17 ) ) -RRB- cord-023134-y665agnh 1428 18 , , , cord-023134-y665agnh 1428 19 systolic systolic JJ cord-023134-y665agnh 1428 20 blood blood NN cord-023134-y665agnh 1428 21 pressure pressure NN cord-023134-y665agnh 1428 22 ( ( -LRB- cord-023134-y665agnh 1428 23 SBP SBP NNP cord-023134-y665agnh 1428 24 ) ) -RRB- cord-023134-y665agnh 1428 25 , , , cord-023134-y665agnh 1428 26 USG USG NNP cord-023134-y665agnh 1428 27 and and CC cord-023134-y665agnh 1428 28 age age NN cord-023134-y665agnh 1428 29 were be VBD cord-023134-y665agnh 1428 30 entered enter VBN cord-023134-y665agnh 1428 31 into into IN cord-023134-y665agnh 1428 32 univariable univariable JJ cord-023134-y665agnh 1428 33 Cox Cox NNP cord-023134-y665agnh 1428 34 regression regression NN cord-023134-y665agnh 1428 35 models model NNS cord-023134-y665agnh 1428 36 of of IN cord-023134-y665agnh 1428 37 survival survival NN cord-023134-y665agnh 1428 38 time time NN cord-023134-y665agnh 1428 39 . . . cord-023134-y665agnh 1429 1 FGF-23 FGF-23 NNP cord-023134-y665agnh 1429 2 concentrations concentration NNS cord-023134-y665agnh 1429 3 were be VBD cord-023134-y665agnh 1429 4 logarithmically logarithmically RB cord-023134-y665agnh 1429 5 transformed transform VBN cord-023134-y665agnh 1429 6 due due IN cord-023134-y665agnh 1429 7 to to IN cord-023134-y665agnh 1429 8 a a DT cord-023134-y665agnh 1429 9 highly highly RB cord-023134-y665agnh 1429 10 skewed skewed JJ cord-023134-y665agnh 1429 11 distribution distribution NN cord-023134-y665agnh 1429 12 . . . cord-023134-y665agnh 1430 1 Statistical statistical JJ cord-023134-y665agnh 1430 2 significance significance NN cord-023134-y665agnh 1430 3 was be VBD cord-023134-y665agnh 1430 4 defined define VBN cord-023134-y665agnh 1430 5 as as IN cord-023134-y665agnh 1430 6 P<0.05 P<0.05 NNS cord-023134-y665agnh 1430 7 . . . cord-023134-y665agnh 1431 1 Variables variable NNS cord-023134-y665agnh 1431 2 with with IN cord-023134-y665agnh 1431 3 P<0.05 P<0.05 NNS cord-023134-y665agnh 1431 4 were be VBD cord-023134-y665agnh 1431 5 carried carry VBN cord-023134-y665agnh 1431 6 forwards forwards RB cord-023134-y665agnh 1431 7 into into IN cord-023134-y665agnh 1431 8 a a DT cord-023134-y665agnh 1431 9 backwards backwards JJ cord-023134-y665agnh 1431 10 , , , cord-023134-y665agnh 1431 11 stepwise stepwise JJ cord-023134-y665agnh 1431 12 multivariable multivariable JJ cord-023134-y665agnh 1431 13 Cox Cox NNP cord-023134-y665agnh 1431 14 regression regression NN cord-023134-y665agnh 1431 15 analysis analysis NN cord-023134-y665agnh 1431 16 of of IN cord-023134-y665agnh 1431 17 survival survival NN cord-023134-y665agnh 1431 18 time time NN cord-023134-y665agnh 1431 19 . . . cord-023134-y665agnh 1432 1 Ninety ninety CD cord-023134-y665agnh 1432 2 - - HYPH cord-023134-y665agnh 1432 3 one one CD cord-023134-y665agnh 1432 4 cats cat NNS cord-023134-y665agnh 1432 5 were be VBD cord-023134-y665agnh 1432 6 included include VBN cord-023134-y665agnh 1432 7 in in IN cord-023134-y665agnh 1432 8 the the DT cord-023134-y665agnh 1432 9 study study NN cord-023134-y665agnh 1432 10 . . . cord-023134-y665agnh 1433 1 At at IN cord-023134-y665agnh 1433 2 the the DT cord-023134-y665agnh 1433 3 end end NN cord-023134-y665agnh 1433 4 of of IN cord-023134-y665agnh 1433 5 the the DT cord-023134-y665agnh 1433 6 follow follow NN cord-023134-y665agnh 1433 7 - - HYPH cord-023134-y665agnh 1433 8 up up NN cord-023134-y665agnh 1433 9 period period NN cord-023134-y665agnh 1433 10 ( ( -LRB- cord-023134-y665agnh 1433 11 February February NNP cord-023134-y665agnh 1433 12 2012 2012 CD cord-023134-y665agnh 1433 13 ) ) -RRB- cord-023134-y665agnh 1433 14 , , , cord-023134-y665agnh 1433 15 64 64 CD cord-023134-y665agnh 1433 16 cats cat NNS cord-023134-y665agnh 1433 17 had have VBD cord-023134-y665agnh 1433 18 been be VBN cord-023134-y665agnh 1433 19 euthanased euthanase VBN cord-023134-y665agnh 1433 20 or or CC cord-023134-y665agnh 1433 21 died die VBN cord-023134-y665agnh 1433 22 ( ( -LRB- cord-023134-y665agnh 1433 23 median median NN cord-023134-y665agnh 1433 24 ( ( -LRB- cord-023134-y665agnh 1433 25 range range NN cord-023134-y665agnh 1433 26 ) ) -RRB- cord-023134-y665agnh 1433 27 survival survival NN cord-023134-y665agnh 1433 28 time time NN cord-023134-y665agnh 1433 29 236 236 CD cord-023134-y665agnh 1433 30 ( ( -LRB- cord-023134-y665agnh 1433 31 0 0 CD cord-023134-y665agnh 1433 32 -1766 -1766 JJ cord-023134-y665agnh 1433 33 ) ) -RRB- cord-023134-y665agnh 1433 34 days day NNS cord-023134-y665agnh 1433 35 ) ) -RRB- cord-023134-y665agnh 1433 36 and and CC cord-023134-y665agnh 1433 37 27 27 CD cord-023134-y665agnh 1433 38 cats cat NNS cord-023134-y665agnh 1433 39 were be VBD cord-023134-y665agnh 1433 40 alive alive JJ cord-023134-y665agnh 1433 41 or or CC cord-023134-y665agnh 1433 42 lost lose VBN cord-023134-y665agnh 1433 43 to to TO cord-023134-y665agnh 1433 44 follow follow VB cord-023134-y665agnh 1433 45 - - HYPH cord-023134-y665agnh 1433 46 up up NN cord-023134-y665agnh 1433 47 ( ( -LRB- cord-023134-y665agnh 1433 48 median median NN cord-023134-y665agnh 1433 49 ( ( -LRB- cord-023134-y665agnh 1433 50 range range NN cord-023134-y665agnh 1433 51 ) ) -RRB- cord-023134-y665agnh 1433 52 survival survival NN cord-023134-y665agnh 1433 53 time time NN cord-023134-y665agnh 1433 54 696 696 CD cord-023134-y665agnh 1433 55 ( ( -LRB- cord-023134-y665agnh 1433 56 42 42 CD cord-023134-y665agnh 1433 57 -1311 -1311 NN cord-023134-y665agnh 1433 58 ) ) -RRB- cord-023134-y665agnh 1433 59 days day NNS cord-023134-y665agnh 1433 60 ) ) -RRB- cord-023134-y665agnh 1433 61 . . . cord-023134-y665agnh 1434 1 Median median JJ cord-023134-y665agnh 1434 2 ( ( -LRB- cord-023134-y665agnh 1434 3 range range NN cord-023134-y665agnh 1434 4 ) ) -RRB- cord-023134-y665agnh 1434 5 age age NN cord-023134-y665agnh 1434 6 at at IN cord-023134-y665agnh 1434 7 diagnosis diagnosis NN cord-023134-y665agnh 1434 8 ( ( -LRB- cord-023134-y665agnh 1434 9 n=85 n=85 NNP cord-023134-y665agnh 1434 10 ) ) -RRB- cord-023134-y665agnh 1434 11 was be VBD cord-023134-y665agnh 1434 12 14.0 14.0 CD cord-023134-y665agnh 1434 13 ( ( -LRB- cord-023134-y665agnh 1434 14 6.6 6.6 CD cord-023134-y665agnh 1434 15 -18.3 -18.3 CD cord-023134-y665agnh 1434 16 ) ) -RRB- cord-023134-y665agnh 1434 17 years year NNS cord-023134-y665agnh 1434 18 . . . cord-023134-y665agnh 1435 1 Univariable Univariable NNP cord-023134-y665agnh 1435 2 Cox Cox NNP cord-023134-y665agnh 1435 3 regression regression NN cord-023134-y665agnh 1435 4 analysis analysis NN cord-023134-y665agnh 1435 5 indicated indicate VBD cord-023134-y665agnh 1435 6 that that IN cord-023134-y665agnh 1435 7 plasma plasma NN cord-023134-y665agnh 1435 8 creatinine creatinine NN cord-023134-y665agnh 1435 9 ( ( -LRB- cord-023134-y665agnh 1435 10 P<0.001 P<0.001 NNP cord-023134-y665agnh 1435 11 ) ) -RRB- cord-023134-y665agnh 1435 12 , , , cord-023134-y665agnh 1435 13 phosphate phosphate NN cord-023134-y665agnh 1435 14 ( ( -LRB- cord-023134-y665agnh 1435 15 P<0.001 P<0.001 NNP cord-023134-y665agnh 1435 16 ) ) -RRB- cord-023134-y665agnh 1435 17 and and CC cord-023134-y665agnh 1435 18 log log NN cord-023134-y665agnh 1435 19 - - HYPH cord-023134-y665agnh 1435 20 FGF23 fgf23 NN cord-023134-y665agnh 1435 21 ( ( -LRB- cord-023134-y665agnh 1435 22 P<0.001 P<0.001 NNS cord-023134-y665agnh 1435 23 ) ) -RRB- cord-023134-y665agnh 1435 24 concentrations concentration NNS cord-023134-y665agnh 1435 25 were be VBD cord-023134-y665agnh 1435 26 negatively negatively RB cord-023134-y665agnh 1435 27 associated associate VBN cord-023134-y665agnh 1435 28 with with IN cord-023134-y665agnh 1435 29 survival survival NN cord-023134-y665agnh 1435 30 time time NN cord-023134-y665agnh 1435 31 , , , cord-023134-y665agnh 1435 32 and and CC cord-023134-y665agnh 1435 33 that that IN cord-023134-y665agnh 1435 34 PCV PCV NNP cord-023134-y665agnh 1435 35 ( ( -LRB- cord-023134-y665agnh 1435 36 P<0.001 P<0.001 NNP cord-023134-y665agnh 1435 37 ) ) -RRB- cord-023134-y665agnh 1435 38 and and CC cord-023134-y665agnh 1435 39 USG USG NNP cord-023134-y665agnh 1435 40 ( ( -LRB- cord-023134-y665agnh 1435 41 P<0.001 P<0.001 NNP cord-023134-y665agnh 1435 42 ) ) -RRB- cord-023134-y665agnh 1435 43 were be VBD cord-023134-y665agnh 1435 44 positively positively RB cord-023134-y665agnh 1435 45 associated associate VBN cord-023134-y665agnh 1435 46 with with IN cord-023134-y665agnh 1435 47 survival survival NN cord-023134-y665agnh 1435 48 time time NN cord-023134-y665agnh 1435 49 . . . cord-023134-y665agnh 1436 1 In in IN cord-023134-y665agnh 1436 2 the the DT cord-023134-y665agnh 1436 3 multivariable multivariable JJ cord-023134-y665agnh 1436 4 model model NN cord-023134-y665agnh 1436 5 ( ( -LRB- cord-023134-y665agnh 1436 6 n=82 n=82 NN cord-023134-y665agnh 1436 7 ) ) -RRB- cord-023134-y665agnh 1436 8 , , , cord-023134-y665agnh 1436 9 plasma plasma NN cord-023134-y665agnh 1436 10 logFGF23 logFGF23 NNP cord-023134-y665agnh 1436 11 ( ( -LRB- cord-023134-y665agnh 1436 12 hazard hazard NN cord-023134-y665agnh 1436 13 ratio ratio NN cord-023134-y665agnh 1436 14 ( ( -LRB- cord-023134-y665agnh 1436 15 HR)=1.327 HR)=1.327 NNP cord-023134-y665agnh 1436 16 , , , cord-023134-y665agnh 1436 17 95 95 CD cord-023134-y665agnh 1436 18 % % NN cord-023134-y665agnh 1436 19 confidence confidence NN cord-023134-y665agnh 1436 20 interval interval NN cord-023134-y665agnh 1436 21 ( ( -LRB- cord-023134-y665agnh 1436 22 CI CI NNP cord-023134-y665agnh 1436 23 ) ) -RRB- cord-023134-y665agnh 1436 24 for for IN cord-023134-y665agnh 1436 25 HR=1.072 hr=1.072 CD cord-023134-y665agnh 1436 26 - - HYPH cord-023134-y665agnh 1436 27 1.644 1.644 CD cord-023134-y665agnh 1436 28 ; ; : cord-023134-y665agnh 1436 29 P=0.009 p=0.009 NN cord-023134-y665agnh 1436 30 ) ) -RRB- cord-023134-y665agnh 1436 31 and and CC cord-023134-y665agnh 1436 32 creatinine creatinine NN cord-023134-y665agnh 1436 33 concentration concentration NN cord-023134-y665agnh 1436 34 ( ( -LRB- cord-023134-y665agnh 1436 35 HR=1.003 HR=1.003 NNP cord-023134-y665agnh 1436 36 , , , cord-023134-y665agnh 1436 37 95 95 CD cord-023134-y665agnh 1436 38 % % NN cord-023134-y665agnh 1436 39 CI CI NNP cord-023134-y665agnh 1436 40 for for IN cord-023134-y665agnh 1436 41 HR=1.002 HR=1.002 NNP cord-023134-y665agnh 1436 42 - - HYPH cord-023134-y665agnh 1436 43 1.004 1.004 CD cord-023134-y665agnh 1436 44 ; ; . cord-023134-y665agnh 1437 1 P<0.001 P<0.001 NNS cord-023134-y665agnh 1437 2 ) ) -RRB- cord-023134-y665agnh 1437 3 were be VBD cord-023134-y665agnh 1437 4 negatively negatively RB cord-023134-y665agnh 1437 5 associated associate VBN cord-023134-y665agnh 1437 6 with with IN cord-023134-y665agnh 1437 7 survival survival NN cord-023134-y665agnh 1437 8 time time NN cord-023134-y665agnh 1437 9 , , , cord-023134-y665agnh 1437 10 and and CC cord-023134-y665agnh 1437 11 PCV PCV NNP cord-023134-y665agnh 1437 12 ( ( -LRB- cord-023134-y665agnh 1437 13 HR=0.936 HR=0.936 NNP cord-023134-y665agnh 1437 14 , , , cord-023134-y665agnh 1437 15 95 95 CD cord-023134-y665agnh 1437 16 % % NN cord-023134-y665agnh 1437 17 CI CI NNP cord-023134-y665agnh 1437 18 for for IN cord-023134-y665agnh 1437 19 HR=0.885 HR=0.885 NNP cord-023134-y665agnh 1437 20 - - HYPH cord-023134-y665agnh 1437 21 0.990 0.990 CD cord-023134-y665agnh 1437 22 ; ; : cord-023134-y665agnh 1437 23 P=0.020 P=0.020 NNP cord-023134-y665agnh 1437 24 ) ) -RRB- cord-023134-y665agnh 1437 25 was be VBD cord-023134-y665agnh 1437 26 positively positively RB cord-023134-y665agnh 1437 27 associated associate VBN cord-023134-y665agnh 1437 28 with with IN cord-023134-y665agnh 1437 29 survival survival NN cord-023134-y665agnh 1437 30 time time NN cord-023134-y665agnh 1437 31 . . . cord-023134-y665agnh 1438 1 Plasma plasma NN cord-023134-y665agnh 1438 2 FGF-23 FGF-23 NNP cord-023134-y665agnh 1438 3 concentration concentration NN cord-023134-y665agnh 1438 4 is be VBZ cord-023134-y665agnh 1438 5 a a DT cord-023134-y665agnh 1438 6 novel novel JJ cord-023134-y665agnh 1438 7 prognostic prognostic JJ cord-023134-y665agnh 1438 8 indicator indicator NN cord-023134-y665agnh 1438 9 in in IN cord-023134-y665agnh 1438 10 feline feline JJ cord-023134-y665agnh 1438 11 CKD CKD NNP cord-023134-y665agnh 1438 12 , , , cord-023134-y665agnh 1438 13 independent independent JJ cord-023134-y665agnh 1438 14 of of IN cord-023134-y665agnh 1438 15 other other JJ cord-023134-y665agnh 1438 16 factors factor NNS cord-023134-y665agnh 1438 17 including include VBG cord-023134-y665agnh 1438 18 plasma plasma NN cord-023134-y665agnh 1438 19 creatinine creatinine NN cord-023134-y665agnh 1438 20 concentration concentration NN cord-023134-y665agnh 1438 21 and and CC cord-023134-y665agnh 1438 22 PCV pcv NN cord-023134-y665agnh 1438 23 . . . cord-023134-y665agnh 1439 1 Future future JJ cord-023134-y665agnh 1439 2 studies study NNS cord-023134-y665agnh 1439 3 should should MD cord-023134-y665agnh 1439 4 investigate investigate VB cord-023134-y665agnh 1439 5 whether whether IN cord-023134-y665agnh 1439 6 Belgium Belgium NNP cord-023134-y665agnh 1439 7 Ragdoll Ragdoll NNP cord-023134-y665agnh 1439 8 breeder breeder NN cord-023134-y665agnh 1439 9 organizations organization NNS cord-023134-y665agnh 1439 10 often often RB cord-023134-y665agnh 1439 11 forewarn forewarn VBP cord-023134-y665agnh 1439 12 Ragdoll Ragdoll NNP cord-023134-y665agnh 1439 13 cat cat NN cord-023134-y665agnh 1439 14 owners owner NNS cord-023134-y665agnh 1439 15 that that IN cord-023134-y665agnh 1439 16 renal renal JJ cord-023134-y665agnh 1439 17 problems problem NNS cord-023134-y665agnh 1439 18 may may MD cord-023134-y665agnh 1439 19 develop develop VB cord-023134-y665agnh 1439 20 due due IN cord-023134-y665agnh 1439 21 to to IN cord-023134-y665agnh 1439 22 polycystic polycystic JJ cord-023134-y665agnh 1439 23 kidney kidney NN cord-023134-y665agnh 1439 24 disease disease NN cord-023134-y665agnh 1439 25 ( ( -LRB- cord-023134-y665agnh 1439 26 PKD PKD NNP cord-023134-y665agnh 1439 27 ) ) -RRB- cord-023134-y665agnh 1439 28 , , , cord-023134-y665agnh 1439 29 chronic chronic JJ cord-023134-y665agnh 1439 30 interstitial interstitial JJ cord-023134-y665agnh 1439 31 nephritis nephritis NN cord-023134-y665agnh 1439 32 , , , cord-023134-y665agnh 1439 33 familial familial JJ cord-023134-y665agnh 1439 34 renal renal JJ cord-023134-y665agnh 1439 35 dysplasia dysplasia NN cord-023134-y665agnh 1439 36 or or CC cord-023134-y665agnh 1439 37 nephrocalcinosis nephrocalcinosis NN cord-023134-y665agnh 1439 38 . . . cord-023134-y665agnh 1440 1 In in IN cord-023134-y665agnh 1440 2 several several JJ cord-023134-y665agnh 1440 3 European european JJ cord-023134-y665agnh 1440 4 countries country NNS cord-023134-y665agnh 1440 5 , , , cord-023134-y665agnh 1440 6 screening screening NN cord-023134-y665agnh 1440 7 of of IN cord-023134-y665agnh 1440 8 Ragdoll Ragdoll NNP cord-023134-y665agnh 1440 9 cats cat NNS cord-023134-y665agnh 1440 10 for for IN cord-023134-y665agnh 1440 11 kidney kidney NN cord-023134-y665agnh 1440 12 disease disease NN cord-023134-y665agnh 1440 13 is be VBZ cord-023134-y665agnh 1440 14 already already RB cord-023134-y665agnh 1440 15 performed perform VBN cord-023134-y665agnh 1440 16 for for IN cord-023134-y665agnh 1440 17 years year NNS cord-023134-y665agnh 1440 18 , , , cord-023134-y665agnh 1440 19 without without IN cord-023134-y665agnh 1440 20 scientific scientific JJ cord-023134-y665agnh 1440 21 evidence evidence NN cord-023134-y665agnh 1440 22 . . . cord-023134-y665agnh 1441 1 Therefore therefore RB cord-023134-y665agnh 1441 2 , , , cord-023134-y665agnh 1441 3 we -PRON- PRP cord-023134-y665agnh 1441 4 aimed aim VBD cord-023134-y665agnh 1441 5 to to TO cord-023134-y665agnh 1441 6 investigate investigate VB cord-023134-y665agnh 1441 7 if if IN cord-023134-y665agnh 1441 8 Ragdoll Ragdoll NNP cord-023134-y665agnh 1441 9 cats cat NNS cord-023134-y665agnh 1441 10 are be VBP cord-023134-y665agnh 1441 11 predisposed predisposed JJ cord-023134-y665agnh 1441 12 for for IN cord-023134-y665agnh 1441 13 kidney kidney NN cord-023134-y665agnh 1441 14 disease disease NN cord-023134-y665agnh 1441 15 Based base VBN cord-023134-y665agnh 1441 16 on on IN cord-023134-y665agnh 1441 17 the the DT cord-023134-y665agnh 1441 18 laboratory laboratory NN cord-023134-y665agnh 1441 19 parameters parameter NNS cord-023134-y665agnh 1441 20 , , , cord-023134-y665agnh 1441 21 one one CD cord-023134-y665agnh 1441 22 Ragdoll Ragdoll NNP cord-023134-y665agnh 1441 23 cat cat NN cord-023134-y665agnh 1441 24 was be VBD cord-023134-y665agnh 1441 25 diagnosed diagnose VBN cord-023134-y665agnh 1441 26 with with IN cord-023134-y665agnh 1441 27 IRIS IRIS NNP cord-023134-y665agnh 1441 28 stage stage NN cord-023134-y665agnh 1441 29 2 2 CD cord-023134-y665agnh 1441 30 chronic chronic JJ cord-023134-y665agnh 1441 31 kidney kidney NN cord-023134-y665agnh 1441 32 disease disease NN cord-023134-y665agnh 1441 33 ( ( -LRB- cord-023134-y665agnh 1441 34 CKD CKD NNP cord-023134-y665agnh 1441 35 ) ) -RRB- cord-023134-y665agnh 1442 1 One one CD cord-023134-y665agnh 1442 2 of of IN cord-023134-y665agnh 1442 3 these these DT cord-023134-y665agnh 1442 4 six six CD cord-023134-y665agnh 1442 5 cats cat NNS cord-023134-y665agnh 1442 6 was be VBD cord-023134-y665agnh 1442 7 the the DT cord-023134-y665agnh 1442 8 Ragdoll Ragdoll NNP cord-023134-y665agnh 1442 9 cat cat NN cord-023134-y665agnh 1442 10 with with IN cord-023134-y665agnh 1442 11 IRIS IRIS NNP cord-023134-y665agnh 1443 1 stage stage NN cord-023134-y665agnh 1443 2 2 2 CD cord-023134-y665agnh 1443 3 CKD CKD NNP cord-023134-y665agnh 1443 4 . . . cord-023134-y665agnh 1444 1 In in IN cord-023134-y665agnh 1444 2 one one CD cord-023134-y665agnh 1444 3 Ragdoll Ragdoll NNP cord-023134-y665agnh 1444 4 cat cat NN cord-023134-y665agnh 1444 5 , , , cord-023134-y665agnh 1444 6 PKD PKD NNP cord-023134-y665agnh 1444 7 could could MD cord-023134-y665agnh 1444 8 not not RB cord-023134-y665agnh 1444 9 be be VB cord-023134-y665agnh 1444 10 excluded exclude VBN cord-023134-y665agnh 1444 11 on on IN cord-023134-y665agnh 1444 12 ultrasonography ultrasonography NN cord-023134-y665agnh 1444 13 because because IN cord-023134-y665agnh 1444 14 one one CD cord-023134-y665agnh 1444 15 cyst cyst NN cord-023134-y665agnh 1444 16 was be VBD cord-023134-y665agnh 1444 17 detected detect VBN cord-023134-y665agnh 1444 18 in in IN cord-023134-y665agnh 1444 19 one one CD cord-023134-y665agnh 1444 20 kidney kidney NN cord-023134-y665agnh 1444 21 . . . cord-023134-y665agnh 1445 1 However however RB cord-023134-y665agnh 1445 2 , , , cord-023134-y665agnh 1445 3 none none NN cord-023134-y665agnh 1445 4 of of IN cord-023134-y665agnh 1445 5 the the DT cord-023134-y665agnh 1445 6 Ragdoll Ragdoll NNP cord-023134-y665agnh 1445 7 cats cat NNS cord-023134-y665agnh 1445 8 was be VBD cord-023134-y665agnh 1445 9 genetically genetically RB cord-023134-y665agnh 1445 10 positive positive JJ cord-023134-y665agnh 1445 11 for for IN cord-023134-y665agnh 1445 12 PKD.Based pkd.based JJ cord-023134-y665agnh 1445 13 on on IN cord-023134-y665agnh 1445 14 this this DT cord-023134-y665agnh 1445 15 study study NN cord-023134-y665agnh 1445 16 , , , cord-023134-y665agnh 1445 17 PKD PKD NNP cord-023134-y665agnh 1445 18 and and CC cord-023134-y665agnh 1445 19 CKD CKD NNP cord-023134-y665agnh 1445 20 appear appear VBP cord-023134-y665agnh 1445 21 to to TO cord-023134-y665agnh 1445 22 be be VB cord-023134-y665agnh 1445 23 uncommon uncommon JJ cord-023134-y665agnh 1445 24 in in IN cord-023134-y665agnh 1445 25 Ragdoll Ragdoll NNP cord-023134-y665agnh 1445 26 cats cat NNS cord-023134-y665agnh 1445 27 residing reside VBG cord-023134-y665agnh 1445 28 in in IN cord-023134-y665agnh 1445 29 Belgium Belgium NNP cord-023134-y665agnh 1445 30 and and CC cord-023134-y665agnh 1445 31 the the DT cord-023134-y665agnh 1445 32 Netherlands Netherlands NNP cord-023134-y665agnh 1445 33 . . . cord-023134-y665agnh 1446 1 However however RB cord-023134-y665agnh 1446 2 , , , cord-023134-y665agnh 1446 3 renal renal JJ cord-023134-y665agnh 1446 4 infarcts infarct NNS cord-023134-y665agnh 1446 5 were be VBD cord-023134-y665agnh 1446 6 seen see VBN cord-023134-y665agnh 1446 7 more more RBR cord-023134-y665agnh 1446 8 commonly commonly RB cord-023134-y665agnh 1446 9 in in IN cord-023134-y665agnh 1446 10 Ragdoll Ragdoll NNP cord-023134-y665agnh 1446 11 cats cat NNS cord-023134-y665agnh 1446 12 compared compare VBN cord-023134-y665agnh 1446 13 to to IN cord-023134-y665agnh 1446 14 an an DT cord-023134-y665agnh 1446 15 age age NN cord-023134-y665agnh 1446 16 - - HYPH cord-023134-y665agnh 1446 17 matched match VBN cord-023134-y665agnh 1446 18 control control NN cord-023134-y665agnh 1446 19 group group NN cord-023134-y665agnh 1446 20 Spain Spain NNP cord-023134-y665agnh 1446 21 Urine urine NN cord-023134-y665agnh 1446 22 markers marker NNS cord-023134-y665agnh 1446 23 are be VBP cord-023134-y665agnh 1446 24 advocated advocate VBN cord-023134-y665agnh 1446 25 to to IN cord-023134-y665agnh 1446 26 early early JJ cord-023134-y665agnh 1446 27 detect detect VB cord-023134-y665agnh 1446 28 kidney kidney NN cord-023134-y665agnh 1446 29 damage damage NN cord-023134-y665agnh 1446 30 in in IN cord-023134-y665agnh 1446 31 the the DT cord-023134-y665agnh 1446 32 clinical clinical JJ cord-023134-y665agnh 1446 33 practice practice NN cord-023134-y665agnh 1446 34 , , , cord-023134-y665agnh 1446 35 nevertheless nevertheless RB cord-023134-y665agnh 1446 36 histology histology NN cord-023134-y665agnh 1446 37 remains remain VBZ cord-023134-y665agnh 1446 38 the the DT cord-023134-y665agnh 1446 39 gold gold NN cord-023134-y665agnh 1446 40 standard standard NN cord-023134-y665agnh 1446 41 . . . cord-023134-y665agnh 1447 1 The the DT cord-023134-y665agnh 1447 2 aim aim NN cord-023134-y665agnh 1447 3 of of IN cord-023134-y665agnh 1447 4 this this DT cord-023134-y665agnh 1447 5 study study NN cord-023134-y665agnh 1447 6 was be VBD cord-023134-y665agnh 1447 7 to to TO cord-023134-y665agnh 1447 8 evaluate evaluate VB cord-023134-y665agnh 1447 9 quali quali JJ cord-023134-y665agnh 1447 10 - - HYPH cord-023134-y665agnh 1447 11 quantitative quantitative JJ cord-023134-y665agnh 1447 12 proteinuria proteinuria NN cord-023134-y665agnh 1447 13 and and CC cord-023134-y665agnh 1447 14 possible possible JJ cord-023134-y665agnh 1447 15 renal renal JJ cord-023134-y665agnh 1447 16 damage damage NN cord-023134-y665agnh 1447 17 using use VBG cord-023134-y665agnh 1447 18 different different JJ cord-023134-y665agnh 1447 19 non non JJ cord-023134-y665agnh 1447 20 - - JJ cord-023134-y665agnh 1447 21 invasive invasive JJ cord-023134-y665agnh 1447 22 tests test NNS cord-023134-y665agnh 1447 23 in in IN cord-023134-y665agnh 1447 24 dogs dog NNS cord-023134-y665agnh 1447 25 affected affect VBN cord-023134-y665agnh 1447 26 by by IN cord-023134-y665agnh 1447 27 leishmaniasis leishmaniasis NN cord-023134-y665agnh 1447 28 . . . cord-023134-y665agnh 1448 1 Based base VBN cord-023134-y665agnh 1448 2 on on IN cord-023134-y665agnh 1448 3 clinical clinical JJ cord-023134-y665agnh 1448 4 signs sign NNS cord-023134-y665agnh 1448 5 and and CC cord-023134-y665agnh 1448 6 serology serology NN cord-023134-y665agnh 1448 7 / / SYM cord-023134-y665agnh 1448 8 cytology cytology NN cord-023134-y665agnh 1448 9 , , , cord-023134-y665agnh 1448 10 26 26 CD cord-023134-y665agnh 1448 11 affected affect VBN cord-023134-y665agnh 1448 12 dogs dog NNS cord-023134-y665agnh 1448 13 ( ( -LRB- cord-023134-y665agnh 1448 14 Leish Leish NNP cord-023134-y665agnh 1448 15 ) ) -RRB- cord-023134-y665agnh 1448 16 were be VBD cord-023134-y665agnh 1448 17 included include VBN cord-023134-y665agnh 1448 18 . . . cord-023134-y665agnh 1449 1 Fifteen fifteen CD cord-023134-y665agnh 1449 2 healthy healthy JJ cord-023134-y665agnh 1449 3 , , , cord-023134-y665agnh 1449 4 non non JJ cord-023134-y665agnh 1449 5 - - JJ cord-023134-y665agnh 1449 6 proteinuric proteinuric JJ cord-023134-y665agnh 1449 7 dogs dog NNS cord-023134-y665agnh 1449 8 were be VBD cord-023134-y665agnh 1449 9 selected select VBN cord-023134-y665agnh 1449 10 as as IN cord-023134-y665agnh 1449 11 Control Control NNP cord-023134-y665agnh 1449 12 . . . cord-023134-y665agnh 1450 1 Upon upon IN cord-023134-y665agnh 1450 2 admission admission NN cord-023134-y665agnh 1450 3 , , , cord-023134-y665agnh 1450 4 all all DT cord-023134-y665agnh 1450 5 dogs dog NNS cord-023134-y665agnh 1450 6 underwent undergo VBD cord-023134-y665agnh 1450 7 to to IN cord-023134-y665agnh 1450 8 physical physical JJ cord-023134-y665agnh 1450 9 examination examination NN cord-023134-y665agnh 1450 10 , , , cord-023134-y665agnh 1450 11 Systolic Systolic NNP cord-023134-y665agnh 1450 12 Blood Blood NNP cord-023134-y665agnh 1450 13 Pressure Pressure NNP cord-023134-y665agnh 1450 14 ( ( -LRB- cord-023134-y665agnh 1450 15 SBP SBP NNP cord-023134-y665agnh 1450 16 ) ) -RRB- cord-023134-y665agnh 1450 17 measurement measurement NN cord-023134-y665agnh 1450 18 , , , cord-023134-y665agnh 1450 19 clinicopathological clinicopathological JJ cord-023134-y665agnh 1450 20 evaluation evaluation NN cord-023134-y665agnh 1450 21 urine urine NN cord-023134-y665agnh 1450 22 High High NNP cord-023134-y665agnh 1450 23 Resolution Resolution NNP cord-023134-y665agnh 1450 24 agarose agarose NN cord-023134-y665agnh 1450 25 and and CC cord-023134-y665agnh 1450 26 Silver Silver NNP cord-023134-y665agnh 1450 27 Staining Staining NNP cord-023134-y665agnh 1450 28 Sodium Sodium NNP cord-023134-y665agnh 1450 29 - - HYPH cord-023134-y665agnh 1450 30 Dodecyl Dodecyl NNP cord-023134-y665agnh 1450 31 - - HYPH cord-023134-y665agnh 1450 32 Sulphate Sulphate NNP cord-023134-y665agnh 1450 33 - - HYPH cord-023134-y665agnh 1450 34 PolyAcrylamide PolyAcrylamide NNP cord-023134-y665agnh 1450 35 gel gel NN cord-023134-y665agnh 1450 36 electrophoresis electrophoresis NN cord-023134-y665agnh 1450 37 ( ( -LRB- cord-023134-y665agnh 1450 38 HRE HRE NNP cord-023134-y665agnh 1450 39 ; ; : cord-023134-y665agnh 1450 40 SDS SDS NNP cord-023134-y665agnh 1450 41 - - HYPH cord-023134-y665agnh 1450 42 PAGE PAGE NNP cord-023134-y665agnh 1450 43 ) ) -RRB- cord-023134-y665agnh 1450 44 were be VBD cord-023134-y665agnh 1450 45 performed perform VBN cord-023134-y665agnh 1450 46 . . . cord-023134-y665agnh 1451 1 A a DT cord-023134-y665agnh 1451 2 cut cut NN cord-023134-y665agnh 1451 3 - - HYPH cord-023134-y665agnh 1451 4 off off NN cord-023134-y665agnh 1451 5 of of IN cord-023134-y665agnh 1451 6 66 66 CD cord-023134-y665agnh 1451 7 kDa kDa NNPS cord-023134-y665agnh 1451 8 was be VBD cord-023134-y665agnh 1451 9 selected select VBN cord-023134-y665agnh 1451 10 to to TO cord-023134-y665agnh 1451 11 classify classify VB cord-023134-y665agnh 1451 12 bands band NNS cord-023134-y665agnh 1451 13 in in IN cord-023134-y665agnh 1451 14 High high JJ cord-023134-y665agnh 1451 15 or or CC cord-023134-y665agnh 1451 16 Low Low NNP cord-023134-y665agnh 1451 17 Molecular Molecular NNP cord-023134-y665agnh 1451 18 Weight Weight NNP cord-023134-y665agnh 1451 19 ( ( -LRB- cord-023134-y665agnh 1451 20 HMW HMW NNP cord-023134-y665agnh 1451 21 ; ; : cord-023134-y665agnh 1451 22 LMW LMW NNP cord-023134-y665agnh 1451 23 ) ) -RRB- cord-023134-y665agnh 1451 24 . . . cord-023134-y665agnh 1452 1 Data datum NNS cord-023134-y665agnh 1452 2 were be VBD cord-023134-y665agnh 1452 3 analyzed analyze VBN cord-023134-y665agnh 1452 4 with with IN cord-023134-y665agnh 1452 5 non non JJ cord-023134-y665agnh 1452 6 - - JJ cord-023134-y665agnh 1452 7 parametric parametric JJ cord-023134-y665agnh 1452 8 statistics statistic NNS cord-023134-y665agnh 1452 9 and and CC cord-023134-y665agnh 1452 10 ROC ROC NNP cord-023134-y665agnh 1452 11 curve curve NN cord-023134-y665agnh 1452 12 analysis analysis NN cord-023134-y665agnh 1452 13 ( ( -LRB- cord-023134-y665agnh 1452 14 ROC ROC NNP cord-023134-y665agnh 1452 15 ) ) -RRB- cord-023134-y665agnh 1452 16 . . . cord-023134-y665agnh 1453 1 A a DT cord-023134-y665agnh 1453 2 difference difference NN cord-023134-y665agnh 1453 3 was be VBD cord-023134-y665agnh 1453 4 considered consider VBN cord-023134-y665agnh 1453 5 significant significant JJ cord-023134-y665agnh 1453 6 for for IN cord-023134-y665agnh 1453 7 p<0.05 p<0.05 CD cord-023134-y665agnh 1454 1 Leish Leish NNP cord-023134-y665agnh 1454 2 dogs dog NNS cord-023134-y665agnh 1454 3 presented present VBD cord-023134-y665agnh 1454 4 significantly significantly RB cord-023134-y665agnh 1454 5 higher high JJR cord-023134-y665agnh 1454 6 UPC UPC NNP cord-023134-y665agnh 1454 7 ( ( -LRB- cord-023134-y665agnh 1454 8 Mean Mean NNP cord-023134-y665agnh 1454 9 3 3 CD cord-023134-y665agnh 1454 10 , , , cord-023134-y665agnh 1455 1 Median median JJ cord-023134-y665agnh 1455 2 1.29 1.29 CD cord-023134-y665agnh 1455 3 ) ) -RRB- cord-023134-y665agnh 1455 4 and and CC cord-023134-y665agnh 1455 5 UAC UAC NNP cord-023134-y665agnh 1455 6 ( ( -LRB- cord-023134-y665agnh 1455 7 Mean mean JJ cord-023134-y665agnh 1455 8 1.62 1.62 CD cord-023134-y665agnh 1455 9 , , , cord-023134-y665agnh 1455 10 Median median JJ cord-023134-y665agnh 1455 11 0.29 0.29 CD cord-023134-y665agnh 1455 12 ) ) -RRB- cord-023134-y665agnh 1455 13 . . . cord-023134-y665agnh 1456 1 RRI RRI NNP cord-023134-y665agnh 1456 2 values value NNS cord-023134-y665agnh 1456 3 were be VBD cord-023134-y665agnh 1456 4 significantly significantly RB cord-023134-y665agnh 1456 5 higher high JJR cord-023134-y665agnh 1456 6 in in IN cord-023134-y665agnh 1456 7 Leish Leish NNP cord-023134-y665agnh 1456 8 ( ( -LRB- cord-023134-y665agnh 1456 9 Mean Mean NNP cord-023134-y665agnh 1456 10 0.72 0.72 CD cord-023134-y665agnh 1456 11 ) ) -RRB- cord-023134-y665agnh 1456 12 than than IN cord-023134-y665agnh 1456 13 Control Control NNP cord-023134-y665agnh 1456 14 ( ( -LRB- cord-023134-y665agnh 1456 15 Mean Mean NNP cord-023134-y665agnh 1456 16 0.64 0.64 CD cord-023134-y665agnh 1456 17 ) ) -RRB- cord-023134-y665agnh 1456 18 . . . cord-023134-y665agnh 1457 1 RRI RRI NNP cord-023134-y665agnh 1457 2 was be VBD cord-023134-y665agnh 1457 3 significantly significantly RB cord-023134-y665agnh 1457 4 correlated correlate VBN cord-023134-y665agnh 1457 5 to to IN cord-023134-y665agnh 1457 6 WBC WBC NNP cord-023134-y665agnh 1457 7 ( ( -LRB- cord-023134-y665agnh 1457 8 r=0.51 r=0.51 NNP cord-023134-y665agnh 1457 9 ) ) -RRB- cord-023134-y665agnh 1457 10 , , , cord-023134-y665agnh 1457 11 Hemoglobin hemoglobin NN cord-023134-y665agnh 1457 12 ( ( -LRB- cord-023134-y665agnh 1457 13 r=0.52 r=0.52 NNP cord-023134-y665agnh 1457 14 ) ) -RRB- cord-023134-y665agnh 1457 15 and and CC cord-023134-y665agnh 1457 16 Albumin albumin NN cord-023134-y665agnh 1457 17 concentrations concentration NNS cord-023134-y665agnh 1457 18 ( ( -LRB- cord-023134-y665agnh 1457 19 r=0.61 r=0.61 NNP cord-023134-y665agnh 1457 20 ) ) -RRB- cord-023134-y665agnh 1457 21 , , , cord-023134-y665agnh 1457 22 USG USG NNP cord-023134-y665agnh 1457 23 ( ( -LRB- cord-023134-y665agnh 1457 24 r=0.60 r=0.60 NNP cord-023134-y665agnh 1457 25 ) ) -RRB- cord-023134-y665agnh 1457 26 and and CC cord-023134-y665agnh 1457 27 UPC UPC NNP cord-023134-y665agnh 1457 28 ( ( -LRB- cord-023134-y665agnh 1457 29 r=0.48 r=0.48 NNP cord-023134-y665agnh 1457 30 ) ) -RRB- cord-023134-y665agnh 1457 31 . . . cord-023134-y665agnh 1458 1 HRE HRE NNP cord-023134-y665agnh 1458 2 and and CC cord-023134-y665agnh 1458 3 SDS SDS NNP cord-023134-y665agnh 1458 4 - - HYPH cord-023134-y665agnh 1458 5 PAGE page NN cord-023134-y665agnh 1458 6 protein protein NN cord-023134-y665agnh 1458 7 patterns pattern NNS cord-023134-y665agnh 1458 8 allow allow VBP cord-023134-y665agnh 1458 9 to to TO cord-023134-y665agnh 1458 10 distinguish distinguish VB cord-023134-y665agnh 1458 11 P p NN cord-023134-y665agnh 1458 12 from from IN cord-023134-y665agnh 1458 13 NP NP NNP cord-023134-y665agnh 1458 14 and and CC cord-023134-y665agnh 1458 15 Control Control NNP cord-023134-y665agnh 1458 16 dogs dog NNS cord-023134-y665agnh 1458 17 . . . cord-023134-y665agnh 1459 1 SDS SDS NNP cord-023134-y665agnh 1459 2 - - HYPH cord-023134-y665agnh 1459 3 PAGE PAGE NNP cord-023134-y665agnh 1459 4 revealed reveal VBD cord-023134-y665agnh 1459 5 a a DT cord-023134-y665agnh 1459 6 significantly significantly RB cord-023134-y665agnh 1459 7 higher high JJR cord-023134-y665agnh 1459 8 number number NN cord-023134-y665agnh 1459 9 of of IN cord-023134-y665agnh 1459 10 bands band NNS cord-023134-y665agnh 1459 11 in in IN cord-023134-y665agnh 1459 12 Leish Leish NNP cord-023134-y665agnh 1459 13 dogs dog NNS cord-023134-y665agnh 1459 14 ( ( -LRB- cord-023134-y665agnh 1459 15 35 35 CD cord-023134-y665agnh 1459 16 - - SYM cord-023134-y665agnh 1459 17 40 40 CD cord-023134-y665agnh 1459 18 ) ) -RRB- cord-023134-y665agnh 1459 19 than than IN cord-023134-y665agnh 1459 20 in in IN cord-023134-y665agnh 1459 21 Control Control NNP cord-023134-y665agnh 1459 22 ( ( -LRB- cord-023134-y665agnh 1459 23 25 25 CD cord-023134-y665agnh 1459 24 - - SYM cord-023134-y665agnh 1459 25 30 30 CD cord-023134-y665agnh 1459 26 ) ) -RRB- cord-023134-y665agnh 1459 27 . . . cord-023134-y665agnh 1460 1 NP NP NNP cord-023134-y665agnh 1460 2 and and CC cord-023134-y665agnh 1460 3 BLP BLP NNP cord-023134-y665agnh 1460 4 dogs dog NNS cord-023134-y665agnh 1460 5 presented present VBD cord-023134-y665agnh 1460 6 a a DT cord-023134-y665agnh 1460 7 significantly significantly RB cord-023134-y665agnh 1460 8 lower low JJR cord-023134-y665agnh 1460 9 number number NN cord-023134-y665agnh 1460 10 of of IN cord-023134-y665agnh 1460 11 LMW lmw NN cord-023134-y665agnh 1460 12 bands band NNS cord-023134-y665agnh 1460 13 than than IN cord-023134-y665agnh 1460 14 P. P. NNP cord-023134-y665agnh 1460 15 Number Number NNP cord-023134-y665agnh 1460 16 of of IN cord-023134-y665agnh 1460 17 bands band NNS cord-023134-y665agnh 1460 18 was be VBD cord-023134-y665agnh 1460 19 significantly significantly RB cord-023134-y665agnh 1460 20 correlated correlate VBN cord-023134-y665agnh 1460 21 to to IN cord-023134-y665agnh 1460 22 UPC UPC NNP cord-023134-y665agnh 1460 23 ( ( -LRB- cord-023134-y665agnh 1460 24 r=0.66 r=0.66 NNP cord-023134-y665agnh 1460 25 ) ) -RRB- cord-023134-y665agnh 1460 26 and and CC cord-023134-y665agnh 1460 27 UAC UAC NNP cord-023134-y665agnh 1460 28 ( ( -LRB- cord-023134-y665agnh 1460 29 r=0.64 r=0.64 NN cord-023134-y665agnh 1460 30 ) ) -RRB- cord-023134-y665agnh 1461 1 In in IN cord-023134-y665agnh 1461 2 humans human NNS cord-023134-y665agnh 1461 3 , , , cord-023134-y665agnh 1461 4 diabetes diabetes NN cord-023134-y665agnh 1461 5 mellitus mellitus NN cord-023134-y665agnh 1461 6 ( ( -LRB- cord-023134-y665agnh 1461 7 DM DM NNP cord-023134-y665agnh 1461 8 ) ) -RRB- cord-023134-y665agnh 1461 9 is be VBZ cord-023134-y665agnh 1461 10 an an DT cord-023134-y665agnh 1461 11 important important JJ cord-023134-y665agnh 1461 12 cause cause NN cord-023134-y665agnh 1461 13 of of IN cord-023134-y665agnh 1461 14 renal renal JJ cord-023134-y665agnh 1461 15 damage damage NN cord-023134-y665agnh 1461 16 . . . cord-023134-y665agnh 1462 1 Main main JJ cord-023134-y665agnh 1462 2 lesions lesion NNS cord-023134-y665agnh 1462 3 include include VBP cord-023134-y665agnh 1462 4 thickening thickening NN cord-023134-y665agnh 1462 5 of of IN cord-023134-y665agnh 1462 6 the the DT cord-023134-y665agnh 1462 7 glomerular glomerular JJ cord-023134-y665agnh 1462 8 basement basement NN cord-023134-y665agnh 1462 9 membrane membrane NN cord-023134-y665agnh 1462 10 and and CC cord-023134-y665agnh 1462 11 mesangial mesangial JJ cord-023134-y665agnh 1462 12 expansion expansion NN cord-023134-y665agnh 1462 13 , , , cord-023134-y665agnh 1462 14 whereas whereas IN cord-023134-y665agnh 1462 15 tubular tubular JJ cord-023134-y665agnh 1462 16 atrophy atrophy NN cord-023134-y665agnh 1462 17 and and CC cord-023134-y665agnh 1462 18 vascular vascular JJ cord-023134-y665agnh 1462 19 hypertrophy hypertrophy NN cord-023134-y665agnh 1462 20 are be VBP cord-023134-y665agnh 1462 21 less less RBR cord-023134-y665agnh 1462 22 frequent frequent JJ cord-023134-y665agnh 1462 23 . . . cord-023134-y665agnh 1463 1 In in IN cord-023134-y665agnh 1463 2 cats cat NNS cord-023134-y665agnh 1463 3 , , , cord-023134-y665agnh 1463 4 although although IN cord-023134-y665agnh 1463 5 diabetes diabetes NN cord-023134-y665agnh 1463 6 is be VBZ cord-023134-y665agnh 1463 7 a a DT cord-023134-y665agnh 1463 8 common common JJ cord-023134-y665agnh 1463 9 endocrinopathy endocrinopathy NN cord-023134-y665agnh 1463 10 , , , cord-023134-y665agnh 1463 11 it -PRON- PRP cord-023134-y665agnh 1463 12 is be VBZ cord-023134-y665agnh 1463 13 yet yet RB cord-023134-y665agnh 1463 14 unknown unknown JJ cord-023134-y665agnh 1463 15 whether whether IN cord-023134-y665agnh 1463 16 DM dm NN cord-023134-y665agnh 1463 17 causes cause VBZ cord-023134-y665agnh 1463 18 renal renal JJ cord-023134-y665agnh 1463 19 damage damage NN cord-023134-y665agnh 1463 20 . . . cord-023134-y665agnh 1464 1 The the DT cord-023134-y665agnh 1464 2 aim aim NN cord-023134-y665agnh 1464 3 of of IN cord-023134-y665agnh 1464 4 the the DT cord-023134-y665agnh 1464 5 present present JJ cord-023134-y665agnh 1464 6 study study NN cord-023134-y665agnh 1464 7 was be VBD cord-023134-y665agnh 1464 8 to to TO cord-023134-y665agnh 1464 9 compare compare VB cord-023134-y665agnh 1464 10 renal renal JJ cord-023134-y665agnh 1464 11 histopathological histopathological JJ cord-023134-y665agnh 1464 12 features feature NNS cord-023134-y665agnh 1464 13 and and CC cord-023134-y665agnh 1464 14 clinical clinical JJ cord-023134-y665agnh 1464 15 parameters parameter NNS cord-023134-y665agnh 1464 16 of of IN cord-023134-y665agnh 1464 17 kidney kidney NN cord-023134-y665agnh 1464 18 function function NN cord-023134-y665agnh 1464 19 in in IN cord-023134-y665agnh 1464 20 diabetic diabetic JJ cord-023134-y665agnh 1464 21 cats cat NNS cord-023134-y665agnh 1464 22 against against IN cord-023134-y665agnh 1464 23 a a DT cord-023134-y665agnh 1464 24 well well RB cord-023134-y665agnh 1464 25 - - HYPH cord-023134-y665agnh 1464 26 matched match VBN cord-023134-y665agnh 1464 27 control control NN cord-023134-y665agnh 1464 28 population population NN cord-023134-y665agnh 1464 29 . . . cord-023134-y665agnh 1465 1 Formalin Formalin NNP cord-023134-y665agnh 1465 2 - - HYPH cord-023134-y665agnh 1465 3 fixed fix VBN cord-023134-y665agnh 1465 4 , , , cord-023134-y665agnh 1465 5 paraffin paraffin NN cord-023134-y665agnh 1465 6 - - HYPH cord-023134-y665agnh 1465 7 embedded embed VBN cord-023134-y665agnh 1465 8 kidney kidney NN cord-023134-y665agnh 1465 9 samples sample NNS cord-023134-y665agnh 1465 10 were be VBD cord-023134-y665agnh 1465 11 retrieved retrieve VBN cord-023134-y665agnh 1465 12 from from IN cord-023134-y665agnh 1465 13 diabetic diabetic JJ cord-023134-y665agnh 1465 14 and and CC cord-023134-y665agnh 1465 15 control control NN cord-023134-y665agnh 1465 16 cats cat NNS cord-023134-y665agnh 1465 17 that that WDT cord-023134-y665agnh 1465 18 died die VBD cord-023134-y665agnh 1465 19 between between IN cord-023134-y665agnh 1465 20 1997 1997 CD cord-023134-y665agnh 1465 21 and and CC cord-023134-y665agnh 1465 22 2009 2009 CD cord-023134-y665agnh 1465 23 due due IN cord-023134-y665agnh 1465 24 to to IN cord-023134-y665agnh 1465 25 any any DT cord-023134-y665agnh 1465 26 disease disease NN cord-023134-y665agnh 1465 27 at at IN cord-023134-y665agnh 1465 28 the the DT cord-023134-y665agnh 1465 29 Clinic Clinic NNP cord-023134-y665agnh 1465 30 for for IN cord-023134-y665agnh 1465 31 Small Small NNP cord-023134-y665agnh 1465 32 Animal Animal NNP cord-023134-y665agnh 1465 33 Internal Internal NNP cord-023134-y665agnh 1465 34 Medicine Medicine NNP cord-023134-y665agnh 1465 35 , , , cord-023134-y665agnh 1465 36 University University NNP cord-023134-y665agnh 1465 37 of of IN cord-023134-y665agnh 1465 38 Zurich Zurich NNP cord-023134-y665agnh 1465 39 ( ( -LRB- cord-023134-y665agnh 1465 40 Switzerland Switzerland NNP cord-023134-y665agnh 1465 41 ) ) -RRB- cord-023134-y665agnh 1465 42 , , , cord-023134-y665agnh 1465 43 and and CC cord-023134-y665agnh 1465 44 in in IN cord-023134-y665agnh 1465 45 which which WDT cord-023134-y665agnh 1465 46 a a DT cord-023134-y665agnh 1465 47 post post JJ cord-023134-y665agnh 1465 48 - - JJ cord-023134-y665agnh 1465 49 mortem mortem JJ cord-023134-y665agnh 1465 50 examination examination NN cord-023134-y665agnh 1465 51 was be VBD cord-023134-y665agnh 1465 52 performed perform VBN cord-023134-y665agnh 1465 53 . . . cord-023134-y665agnh 1466 1 Control control NN cord-023134-y665agnh 1466 2 cats cat NNS cord-023134-y665agnh 1466 3 were be VBD cord-023134-y665agnh 1466 4 selected select VBN cord-023134-y665agnh 1466 5 to to TO cord-023134-y665agnh 1466 6 be be VB cord-023134-y665agnh 1466 7 matched match VBN cord-023134-y665agnh 1466 8 for for IN cord-023134-y665agnh 1466 9 age age NN cord-023134-y665agnh 1466 10 , , , cord-023134-y665agnh 1466 11 sex sex NN cord-023134-y665agnh 1466 12 , , , cord-023134-y665agnh 1466 13 breed breed NN cord-023134-y665agnh 1466 14 and and CC cord-023134-y665agnh 1466 15 body body NN cord-023134-y665agnh 1466 16 weight weight NN cord-023134-y665agnh 1466 17 . . . cord-023134-y665agnh 1467 1 Serum serum NN cord-023134-y665agnh 1467 2 creatinine creatinine NN cord-023134-y665agnh 1467 3 and and CC cord-023134-y665agnh 1467 4 urea urea NN cord-023134-y665agnh 1467 5 levels level NNS cord-023134-y665agnh 1467 6 were be VBD cord-023134-y665agnh 1467 7 analyzed analyze VBN cord-023134-y665agnh 1467 8 if if IN cord-023134-y665agnh 1467 9 they -PRON- PRP cord-023134-y665agnh 1467 10 had have VBD cord-023134-y665agnh 1467 11 been be VBN cord-023134-y665agnh 1467 12 measured measure VBN cord-023134-y665agnh 1467 13 within within IN cord-023134-y665agnh 1467 14 10 10 CD cord-023134-y665agnh 1467 15 days day NNS cord-023134-y665agnh 1467 16 before before IN cord-023134-y665agnh 1467 17 death death NN cord-023134-y665agnh 1467 18 . . . cord-023134-y665agnh 1468 1 Kidney kidney NN cord-023134-y665agnh 1468 2 sections section NNS cord-023134-y665agnh 1468 3 were be VBD cord-023134-y665agnh 1468 4 stained stain VBN cord-023134-y665agnh 1468 5 with with IN cord-023134-y665agnh 1468 6 haematoxilin haematoxilin NNP cord-023134-y665agnh 1468 7 - - HYPH cord-023134-y665agnh 1468 8 eosin eosin NNP cord-023134-y665agnh 1468 9 , , , cord-023134-y665agnh 1468 10 periodic periodic JJ cord-023134-y665agnh 1468 11 acid acid NN cord-023134-y665agnh 1468 12 - - HYPH cord-023134-y665agnh 1468 13 schiff schiff NNP cord-023134-y665agnh 1468 14 ( ( -LRB- cord-023134-y665agnh 1468 15 PAS PAS NNP cord-023134-y665agnh 1468 16 ) ) -RRB- cord-023134-y665agnh 1468 17 , , , cord-023134-y665agnh 1468 18 Masson Masson NNP cord-023134-y665agnh 1468 19 's 's POS cord-023134-y665agnh 1468 20 trichrome trichrome JJ cord-023134-y665agnh 1468 21 , , , cord-023134-y665agnh 1468 22 acid acid JJ cord-023134-y665agnh 1468 23 fuchsine fuchsine NNP cord-023134-y665agnh 1468 24 orange orange NN cord-023134-y665agnh 1468 25 - - HYPH cord-023134-y665agnh 1468 26 g g NN cord-023134-y665agnh 1468 27 ( ( -LRB- cord-023134-y665agnh 1468 28 AFOG AFOG NNP cord-023134-y665agnh 1468 29 ) ) -RRB- cord-023134-y665agnh 1468 30 , , , cord-023134-y665agnh 1468 31 and and CC cord-023134-y665agnh 1468 32 periodic periodic JJ cord-023134-y665agnh 1468 33 acid acid NN cord-023134-y665agnh 1468 34 methenamine methenamine NN cord-023134-y665agnh 1468 35 silver silver NN cord-023134-y665agnh 1468 36 ( ( -LRB- cord-023134-y665agnh 1468 37 PAMS PAMS NNP cord-023134-y665agnh 1468 38 ) ) -RRB- cord-023134-y665agnh 1468 39 . . . cord-023134-y665agnh 1469 1 With with IN cord-023134-y665agnh 1469 2 optical optical JJ cord-023134-y665agnh 1469 3 microscopy microscopy NN cord-023134-y665agnh 1469 4 glomerular glomerular JJ cord-023134-y665agnh 1469 5 , , , cord-023134-y665agnh 1469 6 tubulointerstitial tubulointerstitial JJ cord-023134-y665agnh 1469 7 and and CC cord-023134-y665agnh 1469 8 vascular vascular JJ cord-023134-y665agnh 1469 9 parameters parameter NNS cord-023134-y665agnh 1469 10 were be VBD cord-023134-y665agnh 1469 11 identified identify VBN cord-023134-y665agnh 1469 12 and and CC cord-023134-y665agnh 1469 13 scored score VBD cord-023134-y665agnh 1469 14 using use VBG cord-023134-y665agnh 1469 15 a a DT cord-023134-y665agnh 1469 16 grading grading NN cord-023134-y665agnh 1469 17 scale scale NN cord-023134-y665agnh 1469 18 . . . cord-023134-y665agnh 1470 1 Data datum NNS cord-023134-y665agnh 1470 2 were be VBD cord-023134-y665agnh 1470 3 analyzed analyze VBN cord-023134-y665agnh 1470 4 with with IN cord-023134-y665agnh 1470 5 contingency contingency NN cord-023134-y665agnh 1470 6 tables table NNS cord-023134-y665agnh 1470 7 and and CC cord-023134-y665agnh 1470 8 t t NN cord-023134-y665agnh 1470 9 - - HYPH cord-023134-y665agnh 1470 10 tests test NNS cord-023134-y665agnh 1470 11 . . . cord-023134-y665agnh 1471 1 Thirty thirty CD cord-023134-y665agnh 1471 2 - - HYPH cord-023134-y665agnh 1471 3 two two CD cord-023134-y665agnh 1471 4 diabetic diabetic JJ cord-023134-y665agnh 1471 5 cats cat NNS cord-023134-y665agnh 1471 6 and and CC cord-023134-y665agnh 1471 7 20 20 CD cord-023134-y665agnh 1471 8 matched match VBN cord-023134-y665agnh 1471 9 controls control NNS cord-023134-y665agnh 1471 10 were be VBD cord-023134-y665agnh 1471 11 included include VBN cord-023134-y665agnh 1471 12 . . . cord-023134-y665agnh 1472 1 With with IN cord-023134-y665agnh 1472 2 optical optical JJ cord-023134-y665agnh 1472 3 microscopy microscopy NNS cord-023134-y665agnh 1472 4 , , , cord-023134-y665agnh 1472 5 scores score NNS cord-023134-y665agnh 1472 6 of of IN cord-023134-y665agnh 1472 7 glomerular glomerular JJ cord-023134-y665agnh 1472 8 lesions lesion NNS cord-023134-y665agnh 1472 9 ( ( -LRB- cord-023134-y665agnh 1472 10 i.e. i.e. FW cord-023134-y665agnh 1472 11 , , , cord-023134-y665agnh 1472 12 sclerotic sclerotic JJ cord-023134-y665agnh 1472 13 glomeruli glomerulus NNS cord-023134-y665agnh 1472 14 , , , cord-023134-y665agnh 1472 15 mesangial mesangial JJ cord-023134-y665agnh 1472 16 or or CC cord-023134-y665agnh 1472 17 endocapillary endocapillary JJ cord-023134-y665agnh 1472 18 hypercellularity hypercellularity NN cord-023134-y665agnh 1472 19 , , , cord-023134-y665agnh 1472 20 increased increase VBN cord-023134-y665agnh 1472 21 mesangial mesangial JJ cord-023134-y665agnh 1472 22 matrix matrix NN cord-023134-y665agnh 1472 23 , , , cord-023134-y665agnh 1472 24 immunodeposits immunodeposit NNS cord-023134-y665agnh 1472 25 , , , cord-023134-y665agnh 1472 26 glomerular glomerular JJ cord-023134-y665agnh 1472 27 basement basement NN cord-023134-y665agnh 1472 28 membrane membrane NN cord-023134-y665agnh 1472 29 thickening thickening NN cord-023134-y665agnh 1472 30 , , , cord-023134-y665agnh 1472 31 mesangial mesangial JJ cord-023134-y665agnh 1472 32 interposition interposition NN cord-023134-y665agnh 1472 33 ) ) -RRB- cord-023134-y665agnh 1472 34 , , , cord-023134-y665agnh 1472 35 tubulointerstitial tubulointerstitial JJ cord-023134-y665agnh 1472 36 lesions lesion NNS cord-023134-y665agnh 1472 37 ( ( -LRB- cord-023134-y665agnh 1472 38 i.e. i.e. FW cord-023134-y665agnh 1472 39 , , , cord-023134-y665agnh 1472 40 inflammation inflammation NN cord-023134-y665agnh 1472 41 , , , cord-023134-y665agnh 1472 42 fibrosis fibrosis NN cord-023134-y665agnh 1472 43 , , , cord-023134-y665agnh 1472 44 tubular tubular JJ cord-023134-y665agnh 1472 45 atrophy atrophy NN cord-023134-y665agnh 1472 46 , , , cord-023134-y665agnh 1472 47 necrosis necrosis NN cord-023134-y665agnh 1472 48 and and CC cord-023134-y665agnh 1472 49 lipidosis lipidosis NN cord-023134-y665agnh 1472 50 , , , cord-023134-y665agnh 1472 51 intratubular intratubular NNP cord-023134-y665agnh 1472 52 mineralizations mineralizations NNPS cord-023134-y665agnh 1472 53 ) ) -RRB- cord-023134-y665agnh 1472 54 and and CC cord-023134-y665agnh 1472 55 vascular vascular JJ cord-023134-y665agnh 1472 56 lesions lesion NNS cord-023134-y665agnh 1472 57 ( ( -LRB- cord-023134-y665agnh 1472 58 i.e. i.e. FW cord-023134-y665agnh 1472 59 , , , cord-023134-y665agnh 1472 60 small small JJ cord-023134-y665agnh 1472 61 or or CC cord-023134-y665agnh 1472 62 large large JJ cord-023134-y665agnh 1472 63 artery artery NN cord-023134-y665agnh 1472 64 hypertrophy hypertrophy NN cord-023134-y665agnh 1472 65 ) ) -RRB- cord-023134-y665agnh 1472 66 did do VBD cord-023134-y665agnh 1472 67 not not RB cord-023134-y665agnh 1472 68 differ differ VB cord-023134-y665agnh 1472 69 between between IN cord-023134-y665agnh 1472 70 the the DT cord-023134-y665agnh 1472 71 2 2 CD cord-023134-y665agnh 1472 72 groups group NNS cord-023134-y665agnh 1472 73 . . . cord-023134-y665agnh 1473 1 Overall overall RB cord-023134-y665agnh 1473 2 , , , cord-023134-y665agnh 1473 3 glomerular glomerular JJ cord-023134-y665agnh 1473 4 , , , cord-023134-y665agnh 1473 5 tubulointestitial tubulointestitial JJ cord-023134-y665agnh 1473 6 and and CC cord-023134-y665agnh 1473 7 vascular vascular JJ cord-023134-y665agnh 1473 8 lesions lesion NNS cord-023134-y665agnh 1473 9 were be VBD cord-023134-y665agnh 1473 10 observed observe VBN cord-023134-y665agnh 1473 11 in in IN cord-023134-y665agnh 1473 12 43.8 43.8 CD cord-023134-y665agnh 1473 13 % % NN cord-023134-y665agnh 1473 14 , , , cord-023134-y665agnh 1473 15 57.9 57.9 CD cord-023134-y665agnh 1473 16 % % NN cord-023134-y665agnh 1473 17 and and CC cord-023134-y665agnh 1473 18 6.3 6.3 CD cord-023134-y665agnh 1473 19 % % NN cord-023134-y665agnh 1473 20 of of IN cord-023134-y665agnh 1473 21 diabetic diabetic JJ cord-023134-y665agnh 1473 22 cats cat NNS cord-023134-y665agnh 1473 23 and and CC cord-023134-y665agnh 1473 24 in in IN cord-023134-y665agnh 1473 25 57.9 57.9 CD cord-023134-y665agnh 1473 26 % % NN cord-023134-y665agnh 1473 27 , , , cord-023134-y665agnh 1473 28 78.9 78.9 CD cord-023134-y665agnh 1473 29 % % NN cord-023134-y665agnh 1473 30 and and CC cord-023134-y665agnh 1473 31 15.7 15.7 CD cord-023134-y665agnh 1473 32 % % NN cord-023134-y665agnh 1473 33 of of IN cord-023134-y665agnh 1473 34 the the DT cord-023134-y665agnh 1473 35 controls control NNS cord-023134-y665agnh 1473 36 . . . cord-023134-y665agnh 1474 1 Similarly similarly RB cord-023134-y665agnh 1474 2 , , , cord-023134-y665agnh 1474 3 serum serum NN cord-023134-y665agnh 1474 4 creatinine creatinine NN cord-023134-y665agnh 1474 5 and and CC cord-023134-y665agnh 1474 6 urea urea NN cord-023134-y665agnh 1474 7 levels level NNS cord-023134-y665agnh 1474 8 were be VBD cord-023134-y665agnh 1474 9 not not RB cord-023134-y665agnh 1474 10 different different JJ cord-023134-y665agnh 1474 11 between between IN cord-023134-y665agnh 1474 12 groups group NNS cord-023134-y665agnh 1474 13 ( ( -LRB- cord-023134-y665agnh 1474 14 creatinine creatinine NN cord-023134-y665agnh 1474 15 : : : cord-023134-y665agnh 1474 16 197 197 CD cord-023134-y665agnh 1474 17 ± ± CD cord-023134-y665agnh 1474 18 42 42 CD cord-023134-y665agnh 1474 19 vs. vs. NN cord-023134-y665agnh 1474 20 199 199 CD cord-023134-y665agnh 1474 21 ± ± CD cord-023134-y665agnh 1474 22 46 46 CD cord-023134-y665agnh 1475 1 lmol lmol NNP cord-023134-y665agnh 1475 2 / / SYM cord-023134-y665agnh 1475 3 l l NN cord-023134-y665agnh 1475 4 , , , cord-023134-y665agnh 1475 5 reference reference NN cord-023134-y665agnh 1475 6 : : : cord-023134-y665agnh 1475 7 98 98 CD cord-023134-y665agnh 1475 8 - - SYM cord-023134-y665agnh 1475 9 163 163 CD cord-023134-y665agnh 1475 10 lmol lmol NNP cord-023134-y665agnh 1475 11 / / SYM cord-023134-y665agnh 1475 12 l l NN cord-023134-y665agnh 1475 13 ; ; : cord-023134-y665agnh 1475 14 urea urea NN cord-023134-y665agnh 1475 15 : : : cord-023134-y665agnh 1475 16 18.2 18.2 CD cord-023134-y665agnh 1475 17 ± ± CD cord-023134-y665agnh 1475 18 2.5 2.5 CD cord-023134-y665agnh 1475 19 vs. vs. NN cord-023134-y665agnh 1475 20 18.4 18.4 CD cord-023134-y665agnh 1475 21 ± ± CD cord-023134-y665agnh 1475 22 4.6 4.6 CD cord-023134-y665agnh 1476 1 mmol mmol NNP cord-023134-y665agnh 1476 2 / / SYM cord-023134-y665agnh 1476 3 l l NN cord-023134-y665agnh 1476 4 , , , cord-023134-y665agnh 1476 5 reference reference NN cord-023134-y665agnh 1476 6 : : : cord-023134-y665agnh 1476 7 7.4 7.4 CD cord-023134-y665agnh 1476 8 - - HYPH cord-023134-y665agnh 1476 9 12.6 12.6 CD cord-023134-y665agnh 1476 10 mmol/ mmol/ . cord-023134-y665agnh 1477 1 l).The l).the PRP$ cord-023134-y665agnh 1477 2 results result NNS cord-023134-y665agnh 1477 3 suggest suggest VBP cord-023134-y665agnh 1477 4 that that IN cord-023134-y665agnh 1477 5 DM DM NNP cord-023134-y665agnh 1477 6 in in IN cord-023134-y665agnh 1477 7 cats cat NNS cord-023134-y665agnh 1477 8 does do VBZ cord-023134-y665agnh 1477 9 not not RB cord-023134-y665agnh 1477 10 lead lead VB cord-023134-y665agnh 1477 11 to to IN cord-023134-y665agnh 1477 12 microscopically microscopically RB cord-023134-y665agnh 1477 13 detectable detectable JJ cord-023134-y665agnh 1477 14 renal renal JJ cord-023134-y665agnh 1477 15 lesions lesion NNS cord-023134-y665agnh 1477 16 or or CC cord-023134-y665agnh 1477 17 clinically clinically RB cord-023134-y665agnh 1477 18 relevant relevant JJ cord-023134-y665agnh 1477 19 renal renal JJ cord-023134-y665agnh 1477 20 dysfunction dysfunction NN cord-023134-y665agnh 1477 21 when when WRB cord-023134-y665agnh 1477 22 compared compare VBN cord-023134-y665agnh 1477 23 to to IN cord-023134-y665agnh 1477 24 a a DT cord-023134-y665agnh 1477 25 well well RB cord-023134-y665agnh 1477 26 - - HYPH cord-023134-y665agnh 1477 27 matched match VBN cord-023134-y665agnh 1477 28 control control NN cord-023134-y665agnh 1477 29 group group NN cord-023134-y665agnh 1477 30 . . . cord-023134-y665agnh 1478 1 We -PRON- PRP cord-023134-y665agnh 1478 2 hypothesize hypothesize VBP cord-023134-y665agnh 1478 3 that that IN cord-023134-y665agnh 1478 4 the the DT cord-023134-y665agnh 1478 5 short short JJ cord-023134-y665agnh 1478 6 life life NN cord-023134-y665agnh 1478 7 expectancy expectancy NN cord-023134-y665agnh 1478 8 of of IN cord-023134-y665agnh 1478 9 diabetic diabetic JJ cord-023134-y665agnh 1478 10 cats cat NNS cord-023134-y665agnh 1478 11 and and CC cord-023134-y665agnh 1478 12 the the DT cord-023134-y665agnh 1478 13 low low JJ cord-023134-y665agnh 1478 14 prevalence prevalence NN cord-023134-y665agnh 1478 15 of of IN cord-023134-y665agnh 1478 16 hypertension hypertension NN cord-023134-y665agnh 1478 17 are be VBP cord-023134-y665agnh 1478 18 main main JJ cord-023134-y665agnh 1478 19 reasons reason NNS cord-023134-y665agnh 1478 20 for for IN cord-023134-y665agnh 1478 21 the the DT cord-023134-y665agnh 1478 22 difference difference NN cord-023134-y665agnh 1478 23 to to IN cord-023134-y665agnh 1478 24 human human JJ cord-023134-y665agnh 1478 25 diabetics diabetic NNS cord-023134-y665agnh 1478 26 . . . cord-023134-y665agnh 1479 1 Early early JJ cord-023134-y665agnh 1479 2 diagnosis diagnosis NN cord-023134-y665agnh 1479 3 of of IN cord-023134-y665agnh 1479 4 AKI AKI NNP cord-023134-y665agnh 1479 5 and and CC cord-023134-y665agnh 1479 6 differentiation differentiation NN cord-023134-y665agnh 1479 7 from from IN cord-023134-y665agnh 1479 8 non non JJ cord-023134-y665agnh 1479 9 - - JJ cord-023134-y665agnh 1479 10 renal renal JJ cord-023134-y665agnh 1479 11 disease disease NN cord-023134-y665agnh 1479 12 or or CC cord-023134-y665agnh 1479 13 CKD CKD NNP cord-023134-y665agnh 1479 14 remains remain VBZ cord-023134-y665agnh 1479 15 challenging challenge VBG cord-023134-y665agnh 1479 16 in in IN cord-023134-y665agnh 1479 17 veterinary veterinary JJ cord-023134-y665agnh 1479 18 medicine medicine NN cord-023134-y665agnh 1479 19 . . . cord-023134-y665agnh 1480 1 In in IN cord-023134-y665agnh 1480 2 human human JJ cord-023134-y665agnh 1480 3 medicine medicine NN cord-023134-y665agnh 1480 4 NGAL NGAL NNP cord-023134-y665agnh 1480 5 is be VBZ cord-023134-y665agnh 1480 6 used use VBN cord-023134-y665agnh 1480 7 as as IN cord-023134-y665agnh 1480 8 a a DT cord-023134-y665agnh 1480 9 real real JJ cord-023134-y665agnh 1480 10 time time NN cord-023134-y665agnh 1480 11 indicator indicator NN cord-023134-y665agnh 1480 12 of of IN cord-023134-y665agnh 1480 13 AKI AKI NNP cord-023134-y665agnh 1480 14 but but CC cord-023134-y665agnh 1480 15 few few JJ cord-023134-y665agnh 1480 16 data datum NNS cord-023134-y665agnh 1480 17 exist exist VBP cord-023134-y665agnh 1480 18 in in IN cord-023134-y665agnh 1480 19 veterinary veterinary JJ cord-023134-y665agnh 1480 20 medicine medicine NN cord-023134-y665agnh 1480 21 . . . cord-023134-y665agnh 1481 1 In in IN cord-023134-y665agnh 1481 2 this this DT cord-023134-y665agnh 1481 3 study study NN cord-023134-y665agnh 1481 4 plasma plasma NN cord-023134-y665agnh 1481 5 and and CC cord-023134-y665agnh 1481 6 urine urine NN cord-023134-y665agnh 1481 7 NGAL NGAL NNP cord-023134-y665agnh 1481 8 was be VBD cord-023134-y665agnh 1481 9 measured measure VBN cord-023134-y665agnh 1481 10 in in IN cord-023134-y665agnh 1481 11 18 18 CD cord-023134-y665agnh 1481 12 healthy healthy JJ cord-023134-y665agnh 1481 13 dogs dog NNS cord-023134-y665agnh 1481 14 with with IN cord-023134-y665agnh 1481 15 normal normal JJ cord-023134-y665agnh 1481 16 GFR gfr NN cord-023134-y665agnh 1481 17 ( ( -LRB- cord-023134-y665agnh 1481 18 plasma plasma NN cord-023134-y665agnh 1481 19 inulin inulin NN cord-023134-y665agnh 1481 20 clearance clearance NN cord-023134-y665agnh 1481 21 ) ) -RRB- cord-023134-y665agnh 1481 22 and and CC cord-023134-y665agnh 1481 23 83 83 CD cord-023134-y665agnh 1481 24 dogs dog NNS cord-023134-y665agnh 1481 25 with with IN cord-023134-y665agnh 1481 26 renal renal JJ cord-023134-y665agnh 1481 27 azotemia azotemia NN cord-023134-y665agnh 1481 28 ( ( -LRB- cord-023134-y665agnh 1481 29 creatinine creatinine NN cord-023134-y665agnh 1481 30 > > XX cord-023134-y665agnh 1481 31 1.4mg 1.4mg CD cord-023134-y665agnh 1481 32 / / SYM cord-023134-y665agnh 1481 33 dl dl NN cord-023134-y665agnh 1481 34 and/or and/or CC cord-023134-y665agnh 1481 35 urea urea NNP cord-023134-y665agnh 1482 1 > > XX cord-023134-y665agnh 1483 1 59mg 59mg NNP cord-023134-y665agnh 1483 2 / / SYM cord-023134-y665agnh 1483 3 dl dl NN cord-023134-y665agnh 1483 4 persisting persist VBG cord-023134-y665agnh 1483 5 at at RB cord-023134-y665agnh 1483 6 least least RBS cord-023134-y665agnh 1483 7 24 24 CD cord-023134-y665agnh 1483 8 hours hour NNS cord-023134-y665agnh 1483 9 after after IN cord-023134-y665agnh 1483 10 correction correction NN cord-023134-y665agnh 1483 11 of of IN cord-023134-y665agnh 1483 12 prerenal prerenal JJ cord-023134-y665agnh 1483 13 factors factor NNS cord-023134-y665agnh 1483 14 ) ) -RRB- cord-023134-y665agnh 1483 15 . . . cord-023134-y665agnh 1484 1 Based base VBN cord-023134-y665agnh 1484 2 on on IN cord-023134-y665agnh 1484 3 history history NN cord-023134-y665agnh 1484 4 , , , cord-023134-y665agnh 1484 5 clinical clinical JJ cord-023134-y665agnh 1484 6 course course NN cord-023134-y665agnh 1484 7 , , , cord-023134-y665agnh 1484 8 laboratory laboratory NN cord-023134-y665agnh 1484 9 and and CC cord-023134-y665agnh 1484 10 ultrasonographic ultrasonographic JJ cord-023134-y665agnh 1484 11 findings finding NNS cord-023134-y665agnh 1484 12 , , , cord-023134-y665agnh 1484 13 azotemic azotemic JJ cord-023134-y665agnh 1484 14 dogs dog NNS cord-023134-y665agnh 1484 15 were be VBD cord-023134-y665agnh 1484 16 diagnosed diagnose VBN cord-023134-y665agnh 1484 17 with with IN cord-023134-y665agnh 1484 18 AKI AKI NNP cord-023134-y665agnh 1484 19 ( ( -LRB- cord-023134-y665agnh 1484 20 n=53 n=53 NNP cord-023134-y665agnh 1484 21 ) ) -RRB- cord-023134-y665agnh 1484 22 or or CC cord-023134-y665agnh 1484 23 CKD CKD NNP cord-023134-y665agnh 1484 24 ( ( -LRB- cord-023134-y665agnh 1484 25 n=30 n=30 NNP cord-023134-y665agnh 1484 26 ) ) -RRB- cord-023134-y665agnh 1484 27 . . . cord-023134-y665agnh 1485 1 Urine urine NN cord-023134-y665agnh 1485 2 and and CC cord-023134-y665agnh 1485 3 plasma plasma NN cord-023134-y665agnh 1485 4 NGAL NGAL NNP cord-023134-y665agnh 1485 5 was be VBD cord-023134-y665agnh 1485 6 measured measure VBN cord-023134-y665agnh 1485 7 with with IN cord-023134-y665agnh 1485 8 a a DT cord-023134-y665agnh 1485 9 dog dog NN cord-023134-y665agnh 1485 10 NGAL NGAL NNP cord-023134-y665agnh 1485 11 ELISA ELISA NNP cord-023134-y665agnh 1485 12 Kit Kit NNP cord-023134-y665agnh 1486 1 ( ( -LRB- cord-023134-y665agnh 1486 2 Bioporto Bioporto NNP cord-023134-y665agnh 1486 3 ® ® POS cord-023134-y665agnh 1486 4 Diagnostics Diagnostics NNP cord-023134-y665agnh 1486 5 A A NNP cord-023134-y665agnh 1486 6 / / SYM cord-023134-y665agnh 1486 7 S S NNP cord-023134-y665agnh 1486 8 , , , cord-023134-y665agnh 1486 9 Gentofte Gentofte NNP cord-023134-y665agnh 1486 10 , , , cord-023134-y665agnh 1486 11 Denmark Denmark NNP cord-023134-y665agnh 1486 12 ) ) -RRB- cord-023134-y665agnh 1486 13 . . . cord-023134-y665agnh 1487 1 Intra intra JJ cord-023134-y665agnh 1487 2 - - JJ cord-023134-y665agnh 1487 3 assay assay NN cord-023134-y665agnh 1487 4 variability variability NN cord-023134-y665agnh 1487 5 for for IN cord-023134-y665agnh 1487 6 plasma plasma NN cord-023134-y665agnh 1487 7 and and CC cord-023134-y665agnh 1487 8 urine urine NN cord-023134-y665agnh 1487 9 NGAL NGAL NNP cord-023134-y665agnh 1487 10 was be VBD cord-023134-y665agnh 1487 11 3.1 3.1 CD cord-023134-y665agnh 1487 12 % % NN cord-023134-y665agnh 1487 13 and and CC cord-023134-y665agnh 1487 14 4.8 4.8 CD cord-023134-y665agnh 1487 15 % % NN cord-023134-y665agnh 1487 16 , , , cord-023134-y665agnh 1487 17 respectively respectively RB cord-023134-y665agnh 1487 18 . . . cord-023134-y665agnh 1488 1 Azotemic Azotemic NNP cord-023134-y665agnh 1488 2 dogs dog NNS cord-023134-y665agnh 1488 3 had have VBD cord-023134-y665agnh 1488 4 significantly significantly RB cord-023134-y665agnh 1488 5 higher high JJR cord-023134-y665agnh 1488 6 plasma plasma NN cord-023134-y665agnh 1488 7 NGAL NGAL NNP cord-023134-y665agnh 1488 8 concentrations concentration NNS cord-023134-y665agnh 1488 9 and and CC cord-023134-y665agnh 1488 10 urine urine NN cord-023134-y665agnh 1488 11 NGAL NGAL NNP cord-023134-y665agnh 1488 12 - - HYPH cord-023134-y665agnh 1488 13 creatinine creatinine NN cord-023134-y665agnh 1488 14 ratios ratio NNS cord-023134-y665agnh 1488 15 compared compare VBN cord-023134-y665agnh 1488 16 to to IN cord-023134-y665agnh 1488 17 healthy healthy JJ cord-023134-y665agnh 1488 18 dogs dog NNS cord-023134-y665agnh 1488 19 ( ( -LRB- cord-023134-y665agnh 1488 20 P p NN cord-023134-y665agnh 1488 21 < < XX cord-023134-y665agnh 1488 22 0.001 0.001 CD cord-023134-y665agnh 1488 23 , , , cord-023134-y665agnh 1488 24 Mann Mann NNP cord-023134-y665agnh 1488 25 - - HYPH cord-023134-y665agnh 1488 26 Whitney Whitney NNP cord-023134-y665agnh 1488 27 U U NNP cord-023134-y665agnh 1488 28 - - HYPH cord-023134-y665agnh 1488 29 Test Test NNP cord-023134-y665agnh 1488 30 ) ) -RRB- cord-023134-y665agnh 1488 31 . . . cord-023134-y665agnh 1489 1 Median median JJ cord-023134-y665agnh 1490 1 ( ( -LRB- cord-023134-y665agnh 1490 2 min min NNP cord-023134-y665agnh 1490 3 - - HYPH cord-023134-y665agnh 1490 4 max max NNP cord-023134-y665agnh 1490 5 ) ) -RRB- cord-023134-y665agnh 1490 6 plasma plasma NN cord-023134-y665agnh 1490 7 NGAL NGAL NNP cord-023134-y665agnh 1490 8 concentration concentration NN cord-023134-y665agnh 1490 9 in in IN cord-023134-y665agnh 1490 10 healthy healthy JJ cord-023134-y665agnh 1490 11 dogs dog NNS cord-023134-y665agnh 1490 12 , , , cord-023134-y665agnh 1490 13 dogs dog NNS cord-023134-y665agnh 1490 14 with with IN cord-023134-y665agnh 1490 15 AKI AKI NNP cord-023134-y665agnh 1490 16 and and CC cord-023134-y665agnh 1490 17 CKD CKD NNP cord-023134-y665agnh 1490 18 was be VBD cord-023134-y665agnh 1490 19 10.7 10.7 CD cord-023134-y665agnh 1490 20 ( ( -LRB- cord-023134-y665agnh 1490 21 2.5 2.5 CD cord-023134-y665agnh 1490 22 -21.2 -21.2 CD cord-023134-y665agnh 1490 23 ) ) -RRB- cord-023134-y665agnh 1491 1 ng ng NNP cord-023134-y665agnh 1491 2 / / SYM cord-023134-y665agnh 1491 3 ml ml NNP cord-023134-y665agnh 1491 4 , , , cord-023134-y665agnh 1491 5 49.1 49.1 CD cord-023134-y665agnh 1491 6 ( ( -LRB- cord-023134-y665agnh 1491 7 5.7 5.7 CD cord-023134-y665agnh 1491 8 -469.0 -469.0 CD cord-023134-y665agnh 1491 9 ) ) -RRB- cord-023134-y665agnh 1491 10 ng ng NNP cord-023134-y665agnh 1491 11 / / SYM cord-023134-y665agnh 1491 12 ml ml NN cord-023134-y665agnh 1491 13 and and CC cord-023134-y665agnh 1491 14 35.3 35.3 CD cord-023134-y665agnh 1491 15 ( ( -LRB- cord-023134-y665agnh 1491 16 7.7 7.7 CD cord-023134-y665agnh 1491 17 -97.9 -97.9 NFP cord-023134-y665agnh 1491 18 ) ) -RRB- cord-023134-y665agnh 1491 19 ng ng NN cord-023134-y665agnh 1491 20 / / SYM cord-023134-y665agnh 1491 21 ml ml NNS cord-023134-y665agnh 1491 22 , , , cord-023134-y665agnh 1491 23 respectively respectively RB cord-023134-y665agnh 1491 24 . . . cord-023134-y665agnh 1492 1 Using use VBG cord-023134-y665agnh 1492 2 a a DT cord-023134-y665agnh 1492 3 multiple multiple JJ cord-023134-y665agnh 1492 4 linear linear JJ cord-023134-y665agnh 1492 5 regression regression NN cord-023134-y665agnh 1492 6 model model NN cord-023134-y665agnh 1492 7 in in IN cord-023134-y665agnh 1492 8 the the DT cord-023134-y665agnh 1492 9 azotemic azotemic JJ cord-023134-y665agnh 1492 10 dogs dog NNS cord-023134-y665agnh 1492 11 with with IN cord-023134-y665agnh 1492 12 NGAL NGAL NNP cord-023134-y665agnh 1492 13 as as IN cord-023134-y665agnh 1492 14 dependent dependent JJ cord-023134-y665agnh 1492 15 and and CC cord-023134-y665agnh 1492 16 age age NN cord-023134-y665agnh 1492 17 , , , cord-023134-y665agnh 1492 18 weight weight NN cord-023134-y665agnh 1492 19 , , , cord-023134-y665agnh 1492 20 sex sex NN cord-023134-y665agnh 1492 21 , , , cord-023134-y665agnh 1492 22 AKI AKI NNP cord-023134-y665agnh 1492 23 vs. vs. FW cord-023134-y665agnh 1492 24 CKD CKD NNP cord-023134-y665agnh 1492 25 , , , cord-023134-y665agnh 1492 26 dialysis dialysis NN cord-023134-y665agnh 1492 27 and and CC cord-023134-y665agnh 1492 28 survival survival NN cord-023134-y665agnh 1492 29 as as IN cord-023134-y665agnh 1492 30 independent independent JJ cord-023134-y665agnh 1492 31 variables variable NNS cord-023134-y665agnh 1492 32 revealed reveal VBD cord-023134-y665agnh 1492 33 a a DT cord-023134-y665agnh 1492 34 significant significant JJ cord-023134-y665agnh 1492 35 differ differ NN cord-023134-y665agnh 1492 36 - - HYPH cord-023134-y665agnh 1492 37 ence ence NN cord-023134-y665agnh 1492 38 only only RB cord-023134-y665agnh 1492 39 for for IN cord-023134-y665agnh 1492 40 AKI AKI NNP cord-023134-y665agnh 1492 41 vs. vs. FW cord-023134-y665agnh 1492 42 CKD CKD NNP cord-023134-y665agnh 1492 43 ( ( -LRB- cord-023134-y665agnh 1492 44 P p NN cord-023134-y665agnh 1492 45 = = SYM cord-023134-y665agnh 1492 46 0.005 0.005 CD cord-023134-y665agnh 1492 47 ) ) -RRB- cord-023134-y665agnh 1492 48 . . . cord-023134-y665agnh 1493 1 In in IN cord-023134-y665agnh 1493 2 conclusion conclusion NN cord-023134-y665agnh 1493 3 , , , cord-023134-y665agnh 1493 4 NGAL NGAL NNP cord-023134-y665agnh 1493 5 can can MD cord-023134-y665agnh 1493 6 be be VB cord-023134-y665agnh 1493 7 measured measure VBN cord-023134-y665agnh 1493 8 successfully successfully RB cord-023134-y665agnh 1493 9 in in IN cord-023134-y665agnh 1493 10 plasma plasma NN cord-023134-y665agnh 1493 11 and and CC cord-023134-y665agnh 1493 12 urine urine NN cord-023134-y665agnh 1493 13 of of IN cord-023134-y665agnh 1493 14 healthy healthy JJ cord-023134-y665agnh 1493 15 dogs dog NNS cord-023134-y665agnh 1493 16 and and CC cord-023134-y665agnh 1493 17 dogs dog NNS cord-023134-y665agnh 1493 18 with with IN cord-023134-y665agnh 1493 19 kidney kidney NN cord-023134-y665agnh 1493 20 disease disease NN cord-023134-y665agnh 1493 21 . . . cord-023134-y665agnh 1494 1 Dogs dog NNS cord-023134-y665agnh 1494 2 with with IN cord-023134-y665agnh 1494 3 AKI AKI NNP cord-023134-y665agnh 1494 4 had have VBD cord-023134-y665agnh 1494 5 significantly significantly RB cord-023134-y665agnh 1494 6 higher high JJR cord-023134-y665agnh 1494 7 plasma plasma NN cord-023134-y665agnh 1494 8 NGAL NGAL NNP cord-023134-y665agnh 1494 9 concentration concentration NN cord-023134-y665agnh 1494 10 compared compare VBN cord-023134-y665agnh 1494 11 to to IN cord-023134-y665agnh 1494 12 dogs dog NNS cord-023134-y665agnh 1494 13 with with IN cord-023134-y665agnh 1494 14 CKD CKD NNP cord-023134-y665agnh 1494 15 . . . cord-023134-y665agnh 1495 1 Xanthine Xanthine NNP cord-023134-y665agnh 1495 2 urolithiasis urolithiasis NN cord-023134-y665agnh 1495 3 is be VBZ cord-023134-y665agnh 1495 4 a a DT cord-023134-y665agnh 1495 5 rare rare JJ cord-023134-y665agnh 1495 6 condition condition NN cord-023134-y665agnh 1495 7 accounting account VBG cord-023134-y665agnh 1495 8 for for IN cord-023134-y665agnh 1495 9 0.1 0.1 CD cord-023134-y665agnh 1495 10 % % NN cord-023134-y665agnh 1495 11 of of IN cord-023134-y665agnh 1495 12 all all DT cord-023134-y665agnh 1495 13 canine canine JJ cord-023134-y665agnh 1495 14 urolithiasis urolithiasis NN cord-023134-y665agnh 1495 15 in in IN cord-023134-y665agnh 1495 16 one one CD cord-023134-y665agnh 1495 17 study study NN cord-023134-y665agnh 1495 18 . . . cord-023134-y665agnh 1496 1 This this DT cord-023134-y665agnh 1496 2 pathology pathology NN cord-023134-y665agnh 1496 3 has have VBZ cord-023134-y665agnh 1496 4 been be VBN cord-023134-y665agnh 1496 5 reported report VBN cord-023134-y665agnh 1496 6 as as IN cord-023134-y665agnh 1496 7 a a DT cord-023134-y665agnh 1496 8 primary primary JJ cord-023134-y665agnh 1496 9 disorder disorder NN cord-023134-y665agnh 1496 10 in in IN cord-023134-y665agnh 1496 11 dogs dog NNS cord-023134-y665agnh 1496 12 , , , cord-023134-y665agnh 1496 13 most most RBS cord-023134-y665agnh 1496 14 notably notably RB cord-023134-y665agnh 1496 15 in in IN cord-023134-y665agnh 1496 16 Cavalier Cavalier NNP cord-023134-y665agnh 1496 17 King King NNP cord-023134-y665agnh 1496 18 Charles Charles NNP cord-023134-y665agnh 1496 19 Spaniels Spaniels NNPS cord-023134-y665agnh 1497 1 ( ( -LRB- cord-023134-y665agnh 1497 2 CKCS CKCS NNP cord-023134-y665agnh 1497 3 ) ) -RRB- cord-023134-y665agnh 1497 4 . . . cord-023134-y665agnh 1498 1 Xanthine Xanthine NNP cord-023134-y665agnh 1498 2 is be VBZ cord-023134-y665agnh 1498 3 an an DT cord-023134-y665agnh 1498 4 intermediate intermediate JJ cord-023134-y665agnh 1498 5 product product NN cord-023134-y665agnh 1498 6 of of IN cord-023134-y665agnh 1498 7 purine purine NN cord-023134-y665agnh 1498 8 metabolism metabolism NN cord-023134-y665agnh 1498 9 , , , cord-023134-y665agnh 1498 10 which which WDT cord-023134-y665agnh 1498 11 is be VBZ cord-023134-y665agnh 1498 12 converted convert VBN cord-023134-y665agnh 1498 13 from from IN cord-023134-y665agnh 1498 14 hypoxanthine hypoxanthine NN cord-023134-y665agnh 1498 15 by by IN cord-023134-y665agnh 1498 16 xanthine xanthine NN cord-023134-y665agnh 1498 17 oxidase oxidase NN cord-023134-y665agnh 1498 18 . . . cord-023134-y665agnh 1499 1 Xanthine Xanthine NNP cord-023134-y665agnh 1499 2 is be VBZ cord-023134-y665agnh 1499 3 only only RB cord-023134-y665agnh 1499 4 slightly slightly RB cord-023134-y665agnh 1499 5 soluble soluble JJ cord-023134-y665agnh 1499 6 in in IN cord-023134-y665agnh 1499 7 urine urine NN cord-023134-y665agnh 1499 8 and and CC cord-023134-y665agnh 1499 9 therefore therefore RB cord-023134-y665agnh 1499 10 hyperxanthinuria hyperxanthinuria NNP cord-023134-y665agnh 1499 11 may may MD cord-023134-y665agnh 1499 12 lead lead VB cord-023134-y665agnh 1499 13 to to IN cord-023134-y665agnh 1499 14 urolith urolith NN cord-023134-y665agnh 1499 15 formation formation NN cord-023134-y665agnh 1499 16 . . . cord-023134-y665agnh 1500 1 It -PRON- PRP cord-023134-y665agnh 1500 2 has have VBZ cord-023134-y665agnh 1500 3 been be VBN cord-023134-y665agnh 1500 4 speculated speculate VBN cord-023134-y665agnh 1500 5 that that IN cord-023134-y665agnh 1500 6 some some DT cord-023134-y665agnh 1500 7 CKCS CKCS NNP cord-023134-y665agnh 1500 8 have have VBP cord-023134-y665agnh 1500 9 an an DT cord-023134-y665agnh 1500 10 inherited inherit VBN cord-023134-y665agnh 1500 11 mutation mutation NN cord-023134-y665agnh 1500 12 in in IN cord-023134-y665agnh 1500 13 the the DT cord-023134-y665agnh 1500 14 xanthine xanthine NN cord-023134-y665agnh 1500 15 oxidase oxidase NN cord-023134-y665agnh 1500 16 gene gene NN cord-023134-y665agnh 1500 17 . . . cord-023134-y665agnh 1501 1 In in IN cord-023134-y665agnh 1501 2 humans human NNS cord-023134-y665agnh 1501 3 , , , cord-023134-y665agnh 1501 4 isolated isolate VBN cord-023134-y665agnh 1501 5 deficiency deficiency NN cord-023134-y665agnh 1501 6 of of IN cord-023134-y665agnh 1501 7 xanthine xanthine NN cord-023134-y665agnh 1501 8 oxidase oxidase NN cord-023134-y665agnh 1501 9 occurs occur VBZ cord-023134-y665agnh 1501 10 rarely rarely RB cord-023134-y665agnh 1501 11 and and CC cord-023134-y665agnh 1501 12 approximately approximately RB cord-023134-y665agnh 1501 13 50 50 CD cord-023134-y665agnh 1501 14 % % NN cord-023134-y665agnh 1501 15 of of IN cord-023134-y665agnh 1501 16 individuals individual NNS cord-023134-y665agnh 1501 17 are be VBP cord-023134-y665agnh 1501 18 asymptomatic asymptomatic JJ cord-023134-y665agnh 1501 19 , , , cord-023134-y665agnh 1501 20 despite despite IN cord-023134-y665agnh 1501 21 having have VBG cord-023134-y665agnh 1501 22 significant significant JJ cord-023134-y665agnh 1501 23 xanthinuria xanthinuria NNS cord-023134-y665agnh 1501 24 . . . cord-023134-y665agnh 1502 1 Therefore therefore RB cord-023134-y665agnh 1502 2 we -PRON- PRP cord-023134-y665agnh 1502 3 hypothesised hypothesise VBD cord-023134-y665agnh 1502 4 that that IN cord-023134-y665agnh 1502 5 asymptomatic asymptomatic JJ cord-023134-y665agnh 1502 6 xanthinuria xanthinuria NNP cord-023134-y665agnh 1502 7 may may MD cord-023134-y665agnh 1502 8 be be VB cord-023134-y665agnh 1502 9 commonplace commonplace JJ cord-023134-y665agnh 1502 10 in in IN cord-023134-y665agnh 1502 11 the the DT cord-023134-y665agnh 1502 12 UK UK NNP cord-023134-y665agnh 1502 13 population population NN cord-023134-y665agnh 1502 14 of of IN cord-023134-y665agnh 1502 15 CKCS CKCS NNP cord-023134-y665agnh 1502 16 . . . cord-023134-y665agnh 1503 1 In in IN cord-023134-y665agnh 1503 2 support support NN cord-023134-y665agnh 1503 3 of of IN cord-023134-y665agnh 1503 4 this this DT cord-023134-y665agnh 1503 5 , , , cord-023134-y665agnh 1503 6 a a DT cord-023134-y665agnh 1503 7 previous previous JJ cord-023134-y665agnh 1503 8 case case NN cord-023134-y665agnh 1503 9 report report NN cord-023134-y665agnh 1503 10 of of IN cord-023134-y665agnh 1503 11 a a DT cord-023134-y665agnh 1503 12 symptomatic symptomatic JJ cord-023134-y665agnh 1503 13 CKCS CKCS NNP cord-023134-y665agnh 1503 14 reported report VBD cord-023134-y665agnh 1503 15 significant significant JJ cord-023134-y665agnh 1503 16 xanthinuria xanthinuria NNS cord-023134-y665agnh 1503 17 occurring occur VBG cord-023134-y665agnh 1503 18 in in IN cord-023134-y665agnh 1503 19 an an DT cord-023134-y665agnh 1503 20 asymptomatic asymptomatic JJ cord-023134-y665agnh 1503 21 sibling sibling NN cord-023134-y665agnh 1503 22 . . . cord-023134-y665agnh 1504 1 In in IN cord-023134-y665agnh 1504 2 order order NN cord-023134-y665agnh 1504 3 to to TO cord-023134-y665agnh 1504 4 examine examine VB cord-023134-y665agnh 1504 5 the the DT cord-023134-y665agnh 1504 6 prevalence prevalence NN cord-023134-y665agnh 1504 7 of of IN cord-023134-y665agnh 1504 8 xanthinuria xanthinuria NN cord-023134-y665agnh 1504 9 in in IN cord-023134-y665agnh 1504 10 CKCS CKCS NNP cord-023134-y665agnh 1504 11 , , , cord-023134-y665agnh 1504 12 urine urine NN cord-023134-y665agnh 1504 13 concentrations concentration NNS cord-023134-y665agnh 1504 14 of of IN cord-023134-y665agnh 1504 15 hypoxanthine hypoxanthine NN cord-023134-y665agnh 1504 16 and and CC cord-023134-y665agnh 1504 17 xanthine xanthine NN cord-023134-y665agnh 1504 18 metabolites metabolite NNS cord-023134-y665agnh 1504 19 as as RB cord-023134-y665agnh 1504 20 well well RB cord-023134-y665agnh 1504 21 as as IN cord-023134-y665agnh 1504 22 creatinine creatinine NN cord-023134-y665agnh 1504 23 were be VBD cord-023134-y665agnh 1504 24 measured measure VBN cord-023134-y665agnh 1504 25 in in IN cord-023134-y665agnh 1504 26 35 35 CD cord-023134-y665agnh 1504 27 clientowned clientowned JJ cord-023134-y665agnh 1504 28 Cavalier Cavalier NNP cord-023134-y665agnh 1504 29 King King NNP cord-023134-y665agnh 1504 30 Charles Charles NNP cord-023134-y665agnh 1504 31 Spaniel Spaniel NNP cord-023134-y665agnh 1504 32 dogs dog NNS cord-023134-y665agnh 1504 33 and and CC cord-023134-y665agnh 1504 34 24 24 CD cord-023134-y665agnh 1504 35 dogs dog NNS cord-023134-y665agnh 1504 36 of of IN cord-023134-y665agnh 1504 37 other other JJ cord-023134-y665agnh 1504 38 breeds breed NNS cord-023134-y665agnh 1504 39 from from IN cord-023134-y665agnh 1504 40 three three CD cord-023134-y665agnh 1504 41 first first JJ cord-023134-y665agnh 1504 42 - - HYPH cord-023134-y665agnh 1504 43 opinion opinion NN cord-023134-y665agnh 1504 44 veterinary veterinary JJ cord-023134-y665agnh 1504 45 practices practice NNS cord-023134-y665agnh 1504 46 in in IN cord-023134-y665agnh 1504 47 the the DT cord-023134-y665agnh 1504 48 UK UK NNP cord-023134-y665agnh 1504 49 . . . cord-023134-y665agnh 1505 1 Urine urine NN cord-023134-y665agnh 1505 2 samples sample NNS cord-023134-y665agnh 1505 3 were be VBD cord-023134-y665agnh 1505 4 collected collect VBN cord-023134-y665agnh 1505 5 by by IN cord-023134-y665agnh 1505 6 free free JJ cord-023134-y665agnh 1505 7 catch catch NN cord-023134-y665agnh 1505 8 and and CC cord-023134-y665agnh 1505 9 purine purine NN cord-023134-y665agnh 1505 10 metabolites metabolite NNS cord-023134-y665agnh 1505 11 were be VBD cord-023134-y665agnh 1505 12 measured measure VBN cord-023134-y665agnh 1505 13 by by IN cord-023134-y665agnh 1505 14 high high JJ cord-023134-y665agnh 1505 15 - - HYPH cord-023134-y665agnh 1505 16 performance performance NN cord-023134-y665agnh 1505 17 liquid liquid NN cord-023134-y665agnh 1505 18 chromatography chromatography NN cord-023134-y665agnh 1505 19 . . . cord-023134-y665agnh 1506 1 Ratios ratio NNS cord-023134-y665agnh 1506 2 of of IN cord-023134-y665agnh 1506 3 xanthine xanthine NN cord-023134-y665agnh 1506 4 / / SYM cord-023134-y665agnh 1506 5 creatinine creatinine NN cord-023134-y665agnh 1506 6 and and CC cord-023134-y665agnh 1506 7 hypoxanthine hypoxanthine NN cord-023134-y665agnh 1506 8 / / SYM cord-023134-y665agnh 1506 9 creatinine creatinine NN cord-023134-y665agnh 1506 10 from from IN cord-023134-y665agnh 1506 11 the the DT cord-023134-y665agnh 1506 12 two two CD cord-023134-y665agnh 1506 13 populations population NNS cord-023134-y665agnh 1506 14 were be VBD cord-023134-y665agnh 1506 15 compared compare VBN cord-023134-y665agnh 1506 16 by by IN cord-023134-y665agnh 1506 17 Mann Mann NNP cord-023134-y665agnh 1506 18 Whitney Whitney NNP cord-023134-y665agnh 1506 19 U U NNP cord-023134-y665agnh 1506 20 test test NN cord-023134-y665agnh 1506 21 and and CC cord-023134-y665agnh 1506 22 were be VBD cord-023134-y665agnh 1506 23 found find VBN cord-023134-y665agnh 1506 24 not not RB cord-023134-y665agnh 1506 25 to to TO cord-023134-y665agnh 1506 26 be be VB cord-023134-y665agnh 1506 27 significantly significantly RB cord-023134-y665agnh 1506 28 different different JJ cord-023134-y665agnh 1507 1 ( ( -LRB- cord-023134-y665agnh 1507 2 p=0.41 p=0.41 NNP cord-023134-y665agnh 1507 3 and and CC cord-023134-y665agnh 1507 4 p=0.59 p=0.59 NNP cord-023134-y665agnh 1507 5 respectively respectively RB cord-023134-y665agnh 1507 6 ) ) -RRB- cord-023134-y665agnh 1507 7 . . . cord-023134-y665agnh 1508 1 In in IN cord-023134-y665agnh 1508 2 the the DT cord-023134-y665agnh 1508 3 control control NN cord-023134-y665agnh 1508 4 population population NN cord-023134-y665agnh 1508 5 , , , cord-023134-y665agnh 1508 6 the the DT cord-023134-y665agnh 1508 7 xanthine xanthine NN cord-023134-y665agnh 1508 8 / / SYM cord-023134-y665agnh 1508 9 creatinine creatinine NN cord-023134-y665agnh 1508 10 ratio ratio NN cord-023134-y665agnh 1508 11 ranged range VBD cord-023134-y665agnh 1508 12 from from IN cord-023134-y665agnh 1508 13 0.00018 0.00018 CD cord-023134-y665agnh 1508 14 to to IN cord-023134-y665agnh 1508 15 0.01611 0.01611 CD cord-023134-y665agnh 1508 16 ( ( -LRB- cord-023134-y665agnh 1508 17 median median NN cord-023134-y665agnh 1508 18 0.00069 0.00069 CD cord-023134-y665agnh 1508 19 ) ) -RRB- cord-023134-y665agnh 1508 20 , , , cord-023134-y665agnh 1508 21 while while IN cord-023134-y665agnh 1508 22 in in IN cord-023134-y665agnh 1508 23 the the DT cord-023134-y665agnh 1508 24 CKCS CKCS NNP cord-023134-y665agnh 1508 25 population population NN cord-023134-y665agnh 1508 26 it -PRON- PRP cord-023134-y665agnh 1508 27 ranged range VBD cord-023134-y665agnh 1508 28 from from IN cord-023134-y665agnh 1508 29 0.000154 0.000154 CD cord-023134-y665agnh 1508 30 to to IN cord-023134-y665agnh 1508 31 0.005794 0.005794 CD cord-023134-y665agnh 1508 32 ( ( -LRB- cord-023134-y665agnh 1508 33 median median NN cord-023134-y665agnh 1508 34 0.000435 0.000435 CD cord-023134-y665agnh 1508 35 ) ) -RRB- cord-023134-y665agnh 1508 36 . . . cord-023134-y665agnh 1509 1 These these DT cord-023134-y665agnh 1509 2 results result NNS cord-023134-y665agnh 1509 3 are be VBP cord-023134-y665agnh 1509 4 markedly markedly RB cord-023134-y665agnh 1509 5 lower low JJR cord-023134-y665agnh 1509 6 than than IN cord-023134-y665agnh 1509 7 the the DT cord-023134-y665agnh 1509 8 previously previously RB cord-023134-y665agnh 1509 9 reported report VBN cord-023134-y665agnh 1509 10 case case NN cord-023134-y665agnh 1509 11 of of IN cord-023134-y665agnh 1509 12 xanthine xanthine NN cord-023134-y665agnh 1509 13 urolithiasis urolithiasis NN cord-023134-y665agnh 1509 14 in in IN cord-023134-y665agnh 1509 15 a a DT cord-023134-y665agnh 1509 16 UK UK NNP cord-023134-y665agnh 1509 17 CKCS CKCS NNP cord-023134-y665agnh 1509 18 dog dog NN cord-023134-y665agnh 1509 19 , , , cord-023134-y665agnh 1509 20 which which WDT cord-023134-y665agnh 1509 21 utilised utilise VBD cord-023134-y665agnh 1509 22 the the DT cord-023134-y665agnh 1509 23 same same JJ cord-023134-y665agnh 1509 24 reference reference NN cord-023134-y665agnh 1509 25 laboratory laboratory NN cord-023134-y665agnh 1509 26 ( ( -LRB- cord-023134-y665agnh 1509 27 xanthine xanthine NN cord-023134-y665agnh 1509 28 / / SYM cord-023134-y665agnh 1509 29 creatinine creatinine NN cord-023134-y665agnh 1509 30 ratio ratio NN cord-023134-y665agnh 1509 31 0.406 0.406 CD cord-023134-y665agnh 1509 32 ) ) -RRB- cord-023134-y665agnh 1509 33 . . . cord-023134-y665agnh 1510 1 These these DT cord-023134-y665agnh 1510 2 data datum NNS cord-023134-y665agnh 1510 3 suggest suggest VBP cord-023134-y665agnh 1510 4 that that IN cord-023134-y665agnh 1510 5 asymptomatic asymptomatic JJ cord-023134-y665agnh 1510 6 xanthinuria xanthinuria NN cord-023134-y665agnh 1510 7 is be VBZ cord-023134-y665agnh 1510 8 not not RB cord-023134-y665agnh 1510 9 prevalent prevalent JJ cord-023134-y665agnh 1510 10 in in IN cord-023134-y665agnh 1510 11 the the DT cord-023134-y665agnh 1510 12 UK UK NNP cord-023134-y665agnh 1510 13 CKCS CKCS NNP cord-023134-y665agnh 1510 14 population population NN cord-023134-y665agnh 1510 15 . . .