id sid tid token lemma pos cord-014516-r59usk02 1 1 key key JJ cord-014516-r59usk02 1 2 : : : cord-014516-r59usk02 1 3 cord-014516-r59usk02 cord-014516-r59usk02 CD cord-014516-r59usk02 1 4 authors author NNS cord-014516-r59usk02 1 5 : : : cord-014516-r59usk02 2 1 nan nan NNP cord-014516-r59usk02 2 2 title title NN cord-014516-r59usk02 2 3 : : : cord-014516-r59usk02 2 4 Research Research NNP cord-014516-r59usk02 2 5 Communications Communications NNPS cord-014516-r59usk02 2 6 of of IN cord-014516-r59usk02 2 7 the the DT cord-014516-r59usk02 2 8 24th 24th JJ cord-014516-r59usk02 2 9 ECVIM‐CA ecvim‐ca NN cord-014516-r59usk02 2 10 Congress Congress NNP cord-014516-r59usk02 2 11 date date NN cord-014516-r59usk02 2 12 : : : cord-014516-r59usk02 2 13 2015 2015 CD cord-014516-r59usk02 2 14 - - HYPH cord-014516-r59usk02 2 15 01 01 CD cord-014516-r59usk02 2 16 - - SYM cord-014516-r59usk02 2 17 10 10 CD cord-014516-r59usk02 2 18 journal journal NN cord-014516-r59usk02 2 19 : : : cord-014516-r59usk02 2 20 J J NNP cord-014516-r59usk02 2 21 Vet Vet NNP cord-014516-r59usk02 2 22 Intern Intern NNP cord-014516-r59usk02 2 23 Med Med NNP cord-014516-r59usk02 2 24 DOI doi NN cord-014516-r59usk02 2 25 : : : cord-014516-r59usk02 3 1 10.1111 10.1111 CD cord-014516-r59usk02 3 2 / / SYM cord-014516-r59usk02 3 3 jvim.12491 jvim.12491 NNP cord-014516-r59usk02 3 4 sha sha NNP cord-014516-r59usk02 3 5 : : : cord-014516-r59usk02 3 6 25a10dcacb257ac926ad42124f605189b3789d3f 25a10dcacb257ac926ad42124f605189b3789d3f NNP cord-014516-r59usk02 3 7 doc_id doc_id CD cord-014516-r59usk02 3 8 : : : cord-014516-r59usk02 3 9 14516 14516 CD cord-014516-r59usk02 3 10 cord_uid cord_uid NNS cord-014516-r59usk02 3 11 : : : cord-014516-r59usk02 4 1 r59usk02 r59usk02 NNP cord-014516-r59usk02 4 2 nan nan NNP cord-014516-r59usk02 4 3 Saccharomyces Saccharomyces NNP cord-014516-r59usk02 4 4 boulardii boulardii NNP cord-014516-r59usk02 4 5 ( ( -LRB- cord-014516-r59usk02 4 6 Sb)is Sb)is NNP cord-014516-r59usk02 4 7 a a DT cord-014516-r59usk02 4 8 non non JJ cord-014516-r59usk02 4 9 - - JJ cord-014516-r59usk02 4 10 pathogenic pathogenic JJ cord-014516-r59usk02 4 11 yeast yeast NN cord-014516-r59usk02 4 12 used use VBN cord-014516-r59usk02 4 13 in in IN cord-014516-r59usk02 4 14 the the DT cord-014516-r59usk02 4 15 prevention prevention NN cord-014516-r59usk02 4 16 and and CC cord-014516-r59usk02 4 17 treatment treatment NN cord-014516-r59usk02 4 18 of of IN cord-014516-r59usk02 4 19 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 4 20 disorders disorder NNS cord-014516-r59usk02 4 21 in in IN cord-014516-r59usk02 4 22 human human JJ cord-014516-r59usk02 4 23 beings being NNS cord-014516-r59usk02 4 24 and and CC cord-014516-r59usk02 4 25 horses horse NNS cord-014516-r59usk02 4 26 . . . cord-014516-r59usk02 5 1 The the DT cord-014516-r59usk02 5 2 aim aim NN cord-014516-r59usk02 5 3 of of IN cord-014516-r59usk02 5 4 this this DT cord-014516-r59usk02 5 5 study study NN cord-014516-r59usk02 5 6 was be VBD cord-014516-r59usk02 5 7 to to TO cord-014516-r59usk02 5 8 evaluate evaluate VB cord-014516-r59usk02 5 9 the the DT cord-014516-r59usk02 5 10 effect effect NN cord-014516-r59usk02 5 11 of of IN cord-014516-r59usk02 5 12 Sb Sb NNP cord-014516-r59usk02 5 13 in in IN cord-014516-r59usk02 5 14 healthy healthy JJ cord-014516-r59usk02 5 15 dogs dog NNS cord-014516-r59usk02 5 16 and and CC cord-014516-r59usk02 5 17 dogs dog NNS cord-014516-r59usk02 5 18 with with IN cord-014516-r59usk02 5 19 chronic chronic JJ cord-014516-r59usk02 5 20 enteropathies enteropathy NNS cord-014516-r59usk02 5 21 ( ( -LRB- cord-014516-r59usk02 5 22 CE CE NNP cord-014516-r59usk02 5 23 ) ) -RRB- cord-014516-r59usk02 5 24 . . . cord-014516-r59usk02 6 1 Sb Sb NNP cord-014516-r59usk02 6 2 was be VBD cord-014516-r59usk02 6 3 formulated formulate VBN cord-014516-r59usk02 6 4 in in IN cord-014516-r59usk02 6 5 10x10 10x10 CD cord-014516-r59usk02 6 6 9 9 CD cord-014516-r59usk02 6 7 CFU CFU NNP cord-014516-r59usk02 6 8 capsules capsule NNS cord-014516-r59usk02 6 9 . . . cord-014516-r59usk02 7 1 Its -PRON- PRP$ cord-014516-r59usk02 7 2 concentration concentration NN cord-014516-r59usk02 7 3 and and CC cord-014516-r59usk02 7 4 viability viability NN cord-014516-r59usk02 7 5 within within IN cord-014516-r59usk02 7 6 the the DT cord-014516-r59usk02 7 7 capsules capsule NNS cord-014516-r59usk02 7 8 was be VBD cord-014516-r59usk02 7 9 controlled control VBN cord-014516-r59usk02 7 10 by by IN cord-014516-r59usk02 7 11 yeast yeast NN cord-014516-r59usk02 7 12 culture culture NN cord-014516-r59usk02 7 13 in in IN cord-014516-r59usk02 7 14 subsequent subsequent JJ cord-014516-r59usk02 7 15 steps step NNS cord-014516-r59usk02 7 16 until until IN cord-014516-r59usk02 7 17 expiration expiration NN cord-014516-r59usk02 7 18 date date NN cord-014516-r59usk02 7 19 . . . cord-014516-r59usk02 8 1 Four four CD cord-014516-r59usk02 8 2 healthy healthy JJ cord-014516-r59usk02 8 3 dogs dog NNS cord-014516-r59usk02 8 4 ( ( -LRB- cord-014516-r59usk02 8 5 HD HD NNP cord-014516-r59usk02 8 6 ) ) -RRB- cord-014516-r59usk02 8 7 and and CC cord-014516-r59usk02 8 8 18 18 CD cord-014516-r59usk02 8 9 dogs dog NNS cord-014516-r59usk02 8 10 with with IN cord-014516-r59usk02 8 11 CE CE NNP cord-014516-r59usk02 8 12 ( ( -LRB- cord-014516-r59usk02 8 13 10 10 CD cord-014516-r59usk02 8 14 inflammatory inflammatory JJ cord-014516-r59usk02 8 15 bowel bowel NN cord-014516-r59usk02 8 16 disease disease NN cord-014516-r59usk02 8 17 -IBD -IBD VBN cord-014516-r59usk02 8 18 , , , cord-014516-r59usk02 8 19 8 8 CD cord-014516-r59usk02 8 20 protein protein NN cord-014516-r59usk02 8 21 losing lose VBG cord-014516-r59usk02 8 22 enteropathy enteropathy NNP cord-014516-r59usk02 8 23 -PLE -PLE NNS cord-014516-r59usk02 8 24 ) ) -RRB- cord-014516-r59usk02 8 25 were be VBD cord-014516-r59usk02 8 26 included include VBN cord-014516-r59usk02 8 27 . . . cord-014516-r59usk02 9 1 In in IN cord-014516-r59usk02 9 2 HD HD NNP cord-014516-r59usk02 9 3 Sb Sb NNP cord-014516-r59usk02 9 4 was be VBD cord-014516-r59usk02 9 5 administered administer VBN cord-014516-r59usk02 9 6 for for IN cord-014516-r59usk02 9 7 10 10 CD cord-014516-r59usk02 9 8 days day NNS cord-014516-r59usk02 9 9 ( ( -LRB- cord-014516-r59usk02 9 10 1x10 1x10 CD cord-014516-r59usk02 9 11 9 9 CD cord-014516-r59usk02 9 12 CFU CFU NNP cord-014516-r59usk02 9 13 / / SYM cord-014516-r59usk02 9 14 kg kg NN cord-014516-r59usk02 9 15 BID BID NNP cord-014516-r59usk02 9 16 ) ) -RRB- cord-014516-r59usk02 9 17 ; ; : cord-014516-r59usk02 9 18 daily daily JJ cord-014516-r59usk02 9 19 clinical clinical JJ cord-014516-r59usk02 9 20 evaluation evaluation NN cord-014516-r59usk02 9 21 was be VBD cord-014516-r59usk02 9 22 performed perform VBN cord-014516-r59usk02 9 23 to to TO cord-014516-r59usk02 9 24 assess assess VB cord-014516-r59usk02 9 25 possible possible JJ cord-014516-r59usk02 9 26 adverse adverse JJ cord-014516-r59usk02 9 27 effects effect NNS cord-014516-r59usk02 9 28 and and CC cord-014516-r59usk02 9 29 quantitative quantitative JJ cord-014516-r59usk02 9 30 stool stool NN cord-014516-r59usk02 9 31 cultures culture NNS cord-014516-r59usk02 9 32 for for IN cord-014516-r59usk02 9 33 yeasts yeast NNS cord-014516-r59usk02 9 34 were be VBD cord-014516-r59usk02 9 35 performed perform VBN cord-014516-r59usk02 9 36 before before RB cord-014516-r59usk02 9 37 , , , cord-014516-r59usk02 9 38 during during IN cord-014516-r59usk02 9 39 and and CC cord-014516-r59usk02 9 40 after after IN cord-014516-r59usk02 9 41 the the DT cord-014516-r59usk02 9 42 administration administration NN cord-014516-r59usk02 9 43 . . . cord-014516-r59usk02 10 1 In in IN cord-014516-r59usk02 10 2 dogs dog NNS cord-014516-r59usk02 10 3 with with IN cord-014516-r59usk02 10 4 CE CE NNP cord-014516-r59usk02 10 5 a a DT cord-014516-r59usk02 10 6 randomized randomized JJ cord-014516-r59usk02 10 7 double double JJ cord-014516-r59usk02 10 8 blind blind JJ cord-014516-r59usk02 10 9 placebo placebo NN cord-014516-r59usk02 10 10 - - HYPH cord-014516-r59usk02 10 11 control control NN cord-014516-r59usk02 10 12 study study NN cord-014516-r59usk02 10 13 was be VBD cord-014516-r59usk02 10 14 performed perform VBN cord-014516-r59usk02 10 15 , , , cord-014516-r59usk02 10 16 administering administer VBG cord-014516-r59usk02 10 17 Sb Sb NNP cord-014516-r59usk02 10 18 ( ( -LRB- cord-014516-r59usk02 10 19 1x10 1x10 CD cord-014516-r59usk02 10 20 9 9 CD cord-014516-r59usk02 10 21 CFU CFU NNP cord-014516-r59usk02 10 22 / / SYM cord-014516-r59usk02 10 23 kg kg NN cord-014516-r59usk02 10 24 BID BID NNP cord-014516-r59usk02 10 25 ) ) -RRB- cord-014516-r59usk02 10 26 or or CC cord-014516-r59usk02 10 27 placebo placebo NN cord-014516-r59usk02 10 28 ( ( -LRB- cord-014516-r59usk02 10 29 Pl Pl NNP cord-014516-r59usk02 10 30 ) ) -RRB- cord-014516-r59usk02 10 31 . . . cord-014516-r59usk02 11 1 Sb Sb NNP cord-014516-r59usk02 11 2 or or CC cord-014516-r59usk02 11 3 Pl Pl NNP cord-014516-r59usk02 11 4 administration administration NN cord-014516-r59usk02 11 5 was be VBD cord-014516-r59usk02 11 6 added add VBN cord-014516-r59usk02 11 7 to to IN cord-014516-r59usk02 11 8 standard standard JJ cord-014516-r59usk02 11 9 therapeutic therapeutic JJ cord-014516-r59usk02 11 10 protocols protocol NNS cord-014516-r59usk02 11 11 ( ( -LRB- cord-014516-r59usk02 11 12 diet diet NN cord-014516-r59usk02 11 13 , , , cord-014516-r59usk02 11 14 antibiotics antibiotic NNS cord-014516-r59usk02 11 15 and and CC cord-014516-r59usk02 11 16 immunosuppressive immunosuppressive JJ cord-014516-r59usk02 11 17 drugs drug NNS cord-014516-r59usk02 11 18 ) ) -RRB- cord-014516-r59usk02 11 19 , , , cord-014516-r59usk02 11 20 to to TO cord-014516-r59usk02 11 21 evaluate evaluate VB cord-014516-r59usk02 11 22 its -PRON- PRP$ cord-014516-r59usk02 11 23 efficacy efficacy NN cord-014516-r59usk02 11 24 for for IN cord-014516-r59usk02 11 25 the the DT cord-014516-r59usk02 11 26 treatment treatment NN cord-014516-r59usk02 11 27 of of IN cord-014516-r59usk02 11 28 IBD IBD NNP cord-014516-r59usk02 11 29 and and CC cord-014516-r59usk02 11 30 PLE PLE NNP cord-014516-r59usk02 11 31 . . . cord-014516-r59usk02 12 1 Complete complete JJ cord-014516-r59usk02 12 2 blood blood NN cord-014516-r59usk02 12 3 work work NN cord-014516-r59usk02 12 4 , , , cord-014516-r59usk02 12 5 abdominal abdominal JJ cord-014516-r59usk02 12 6 ultrasonography ultrasonography NN cord-014516-r59usk02 12 7 , , , cord-014516-r59usk02 12 8 gastro gastro JJ cord-014516-r59usk02 12 9 - - JJ cord-014516-r59usk02 12 10 duodenal duodenal JJ cord-014516-r59usk02 12 11 and and CC cord-014516-r59usk02 12 12 colon colon NN cord-014516-r59usk02 12 13 endoscopy endoscopy NN cord-014516-r59usk02 12 14 and and CC cord-014516-r59usk02 12 15 histopathological histopathological JJ cord-014516-r59usk02 12 16 evaluation evaluation NN cord-014516-r59usk02 12 17 of of IN cord-014516-r59usk02 12 18 intestinal intestinal JJ cord-014516-r59usk02 12 19 samples sample NNS cord-014516-r59usk02 12 20 were be VBD cord-014516-r59usk02 12 21 performed perform VBN cord-014516-r59usk02 12 22 at at IN cord-014516-r59usk02 12 23 diagnosis diagnosis NN cord-014516-r59usk02 12 24 and and CC cord-014516-r59usk02 12 25 after after IN cord-014516-r59usk02 12 26 60 60 CD cord-014516-r59usk02 12 27 days day NNS cord-014516-r59usk02 12 28 of of IN cord-014516-r59usk02 12 29 treatment treatment NN cord-014516-r59usk02 12 30 . . . cord-014516-r59usk02 13 1 Validated validated JJ cord-014516-r59usk02 13 2 score score NN cord-014516-r59usk02 13 3 system system NN cord-014516-r59usk02 13 4 for for IN cord-014516-r59usk02 13 5 the the DT cord-014516-r59usk02 13 6 clinical clinical JJ cord-014516-r59usk02 13 7 signs sign NNS cord-014516-r59usk02 13 8 ( ( -LRB- cord-014516-r59usk02 13 9 CECCAI CECCAI NNP cord-014516-r59usk02 13 10 ) ) -RRB- cord-014516-r59usk02 13 11 , , , cord-014516-r59usk02 13 12 ultrasonography ultrasonography NN cord-014516-r59usk02 13 13 , , , cord-014516-r59usk02 13 14 endoscopy endoscopy NN cord-014516-r59usk02 13 15 and and CC cord-014516-r59usk02 13 16 histopathology histopathology NN cord-014516-r59usk02 13 17 were be VBD cord-014516-r59usk02 13 18 applied apply VBN cord-014516-r59usk02 13 19 . . . cord-014516-r59usk02 14 1 Significance significance NN cord-014516-r59usk02 14 2 was be VBD cord-014516-r59usk02 14 3 set set VBN cord-014516-r59usk02 14 4 for for IN cord-014516-r59usk02 14 5 P p NN cord-014516-r59usk02 14 6 < < XX cord-014516-r59usk02 14 7 0.05 0.05 CD cord-014516-r59usk02 14 8 . . . cord-014516-r59usk02 15 1 Results result NNS cord-014516-r59usk02 15 2 in in IN cord-014516-r59usk02 15 3 HD hd NN cord-014516-r59usk02 15 4 showed show VBD cord-014516-r59usk02 15 5 the the DT cord-014516-r59usk02 15 6 absence absence NN cord-014516-r59usk02 15 7 of of IN cord-014516-r59usk02 15 8 Sb Sb NNP cord-014516-r59usk02 15 9 in in IN cord-014516-r59usk02 15 10 the the DT cord-014516-r59usk02 15 11 faeces faece NNS cord-014516-r59usk02 15 12 before before IN cord-014516-r59usk02 15 13 treatment treatment NN cord-014516-r59usk02 15 14 , , , cord-014516-r59usk02 15 15 its -PRON- PRP$ cord-014516-r59usk02 15 16 presence presence NN cord-014516-r59usk02 15 17 after after IN cord-014516-r59usk02 15 18 one one CD cord-014516-r59usk02 15 19 day day NN cord-014516-r59usk02 15 20 , , , cord-014516-r59usk02 15 21 its -PRON- PRP$ cord-014516-r59usk02 15 22 steady steady JJ cord-014516-r59usk02 15 23 state state NN cord-014516-r59usk02 15 24 ( ( -LRB- cord-014516-r59usk02 15 25 10x10 10x10 CD cord-014516-r59usk02 15 26 7 7 CD cord-014516-r59usk02 15 27 CFU CFU NNP cord-014516-r59usk02 15 28 / / SYM cord-014516-r59usk02 15 29 g g NN cord-014516-r59usk02 15 30 ) ) -RRB- cord-014516-r59usk02 15 31 after after IN cord-014516-r59usk02 15 32 5 5 CD cord-014516-r59usk02 15 33 days day NNS cord-014516-r59usk02 15 34 and and CC cord-014516-r59usk02 15 35 its -PRON- PRP$ cord-014516-r59usk02 15 36 complete complete JJ cord-014516-r59usk02 15 37 elimination elimination NN cord-014516-r59usk02 15 38 4 4 CD cord-014516-r59usk02 15 39 days day NNS cord-014516-r59usk02 15 40 after after IN cord-014516-r59usk02 15 41 withdrawal withdrawal NN cord-014516-r59usk02 15 42 of of IN cord-014516-r59usk02 15 43 treatment treatment NN cord-014516-r59usk02 15 44 . . . cord-014516-r59usk02 16 1 No no DT cord-014516-r59usk02 16 2 adverse adverse JJ cord-014516-r59usk02 16 3 effects effect NNS cord-014516-r59usk02 16 4 were be VBD cord-014516-r59usk02 16 5 reported report VBN cord-014516-r59usk02 16 6 . . . cord-014516-r59usk02 17 1 In in IN cord-014516-r59usk02 17 2 CE CE NNP cord-014516-r59usk02 17 3 dogs dog VBZ cord-014516-r59usk02 17 4 the the DT cord-014516-r59usk02 17 5 clinical clinical JJ cord-014516-r59usk02 17 6 score score NN cord-014516-r59usk02 17 7 improved improve VBN cord-014516-r59usk02 17 8 significantly significantly RB cord-014516-r59usk02 17 9 in in IN cord-014516-r59usk02 17 10 dogs dog NNS cord-014516-r59usk02 17 11 receiving receive VBG cord-014516-r59usk02 17 12 Sb Sb NNP cord-014516-r59usk02 17 13 compared compare VBN cord-014516-r59usk02 17 14 to to IN cord-014516-r59usk02 17 15 dogs dog NNS cord-014516-r59usk02 17 16 receiving receive VBG cord-014516-r59usk02 17 17 Pl Pl NNP cord-014516-r59usk02 17 18 ( ( -LRB- cord-014516-r59usk02 17 19 P p NN cord-014516-r59usk02 17 20 = = SYM cord-014516-r59usk02 17 21 0.009 0.009 CD cord-014516-r59usk02 17 22 ) ) -RRB- cord-014516-r59usk02 17 23 . . . cord-014516-r59usk02 18 1 In in IN cord-014516-r59usk02 18 2 PLE PLE NNP cord-014516-r59usk02 18 3 dogs dog NNS cord-014516-r59usk02 19 1 the the DT cord-014516-r59usk02 19 2 albumin albumin NN cord-014516-r59usk02 19 3 concentration concentration NN cord-014516-r59usk02 19 4 increased increase VBD cord-014516-r59usk02 19 5 significantly significantly RB cord-014516-r59usk02 20 1 ( ( -LRB- cord-014516-r59usk02 20 2 P p NN cord-014516-r59usk02 20 3 = = SYM cord-014516-r59usk02 20 4 0.034 0.034 CD cord-014516-r59usk02 20 5 ) ) -RRB- cord-014516-r59usk02 21 1 in in IN cord-014516-r59usk02 21 2 the the DT cord-014516-r59usk02 21 3 group group NN cord-014516-r59usk02 21 4 receiving receive VBG cord-014516-r59usk02 21 5 Sb Sb NNP cord-014516-r59usk02 21 6 with with IN cord-014516-r59usk02 21 7 respect respect NN cord-014516-r59usk02 21 8 to to IN cord-014516-r59usk02 21 9 Pl Pl NNP cord-014516-r59usk02 21 10 . . . cord-014516-r59usk02 22 1 The the DT cord-014516-r59usk02 22 2 daily daily JJ cord-014516-r59usk02 22 3 frequency frequency NN cord-014516-r59usk02 22 4 of of IN cord-014516-r59usk02 22 5 defecation defecation NN cord-014516-r59usk02 22 6 in in IN cord-014516-r59usk02 22 7 the the DT cord-014516-r59usk02 22 8 Sb Sb NNP cord-014516-r59usk02 22 9 group group NN cord-014516-r59usk02 22 10 was be VBD cord-014516-r59usk02 22 11 significantly significantly RB cord-014516-r59usk02 22 12 lower low JJR cord-014516-r59usk02 22 13 with with IN cord-014516-r59usk02 22 14 respect respect NN cord-014516-r59usk02 22 15 to to IN cord-014516-r59usk02 22 16 Pl Pl NNP cord-014516-r59usk02 22 17 after after IN cord-014516-r59usk02 22 18 45 45 CD cord-014516-r59usk02 22 19 ( ( -LRB- cord-014516-r59usk02 22 20 P p NN cord-014516-r59usk02 22 21 = = SYM cord-014516-r59usk02 22 22 0.032 0.032 CD cord-014516-r59usk02 22 23 ) ) -RRB- cord-014516-r59usk02 22 24 and and CC cord-014516-r59usk02 22 25 60 60 CD cord-014516-r59usk02 22 26 ( ( -LRB- cord-014516-r59usk02 22 27 P p NN cord-014516-r59usk02 22 28 = = SYM cord-014516-r59usk02 22 29 0.004 0.004 CD cord-014516-r59usk02 22 30 ) ) -RRB- cord-014516-r59usk02 22 31 days day NNS cord-014516-r59usk02 22 32 of of IN cord-014516-r59usk02 22 33 treatment treatment NN cord-014516-r59usk02 22 34 . . . cord-014516-r59usk02 23 1 No no DT cord-014516-r59usk02 23 2 statistical statistical JJ cord-014516-r59usk02 23 3 differences difference NNS cord-014516-r59usk02 23 4 were be VBD cord-014516-r59usk02 23 5 found find VBN cord-014516-r59usk02 23 6 between between IN cord-014516-r59usk02 23 7 dogs dog NNS cord-014516-r59usk02 23 8 receiving receive VBG cord-014516-r59usk02 23 9 Sb Sb NNP cord-014516-r59usk02 23 10 and and CC cord-014516-r59usk02 23 11 Pl Pl NNP cord-014516-r59usk02 23 12 after after IN cord-014516-r59usk02 23 13 treatment treatment NN cord-014516-r59usk02 23 14 , , , cord-014516-r59usk02 23 15 based base VBN cord-014516-r59usk02 23 16 on on IN cord-014516-r59usk02 23 17 the the DT cord-014516-r59usk02 23 18 endoscopic endoscopic JJ cord-014516-r59usk02 23 19 evaluation evaluation NN cord-014516-r59usk02 23 20 of of IN cord-014516-r59usk02 23 21 duodenum duodenum NN cord-014516-r59usk02 23 22 and and CC cord-014516-r59usk02 23 23 colon colon NN cord-014516-r59usk02 23 24 . . . cord-014516-r59usk02 24 1 No no DT cord-014516-r59usk02 24 2 statistical statistical JJ cord-014516-r59usk02 24 3 differences difference NNS cord-014516-r59usk02 24 4 were be VBD cord-014516-r59usk02 24 5 found find VBN cord-014516-r59usk02 24 6 between between IN cord-014516-r59usk02 24 7 the the DT cord-014516-r59usk02 24 8 two two CD cord-014516-r59usk02 24 9 groups group NNS cord-014516-r59usk02 24 10 on on IN cord-014516-r59usk02 24 11 the the DT cord-014516-r59usk02 24 12 duodenal duodenal JJ cord-014516-r59usk02 24 13 ultrasonographic ultrasonographic JJ cord-014516-r59usk02 24 14 and and CC cord-014516-r59usk02 24 15 histological histological JJ cord-014516-r59usk02 24 16 evaluation evaluation NN cord-014516-r59usk02 24 17 after after IN cord-014516-r59usk02 24 18 treatment treatment NN cord-014516-r59usk02 24 19 . . . cord-014516-r59usk02 25 1 In in IN cord-014516-r59usk02 25 2 conclusion conclusion NN cord-014516-r59usk02 25 3 , , , cord-014516-r59usk02 25 4 Sb Sb NNP cord-014516-r59usk02 25 5 can can MD cord-014516-r59usk02 25 6 be be VB cord-014516-r59usk02 25 7 safely safely RB cord-014516-r59usk02 25 8 used use VBN cord-014516-r59usk02 25 9 in in IN cord-014516-r59usk02 25 10 dogs dog NNS cord-014516-r59usk02 25 11 with with IN cord-014516-r59usk02 25 12 CE CE NNP cord-014516-r59usk02 25 13 , , , cord-014516-r59usk02 25 14 in in IN cord-014516-r59usk02 25 15 addition addition NN cord-014516-r59usk02 25 16 to to IN cord-014516-r59usk02 25 17 standard standard JJ cord-014516-r59usk02 25 18 treatment treatment NN cord-014516-r59usk02 25 19 , , , cord-014516-r59usk02 25 20 to to TO cord-014516-r59usk02 25 21 achieve achieve VB cord-014516-r59usk02 25 22 a a DT cord-014516-r59usk02 25 23 better well JJR cord-014516-r59usk02 25 24 control control NN cord-014516-r59usk02 25 25 of of IN cord-014516-r59usk02 25 26 clinical clinical JJ cord-014516-r59usk02 25 27 signs sign NNS cord-014516-r59usk02 25 28 and and CC cord-014516-r59usk02 25 29 a a DT cord-014516-r59usk02 25 30 significant significant JJ cord-014516-r59usk02 25 31 increase increase NN cord-014516-r59usk02 25 32 in in IN cord-014516-r59usk02 25 33 albumin albumin NN cord-014516-r59usk02 25 34 concentration concentration NN cord-014516-r59usk02 25 35 compared compare VBN cord-014516-r59usk02 25 36 to to IN cord-014516-r59usk02 25 37 the the DT cord-014516-r59usk02 25 38 standard standard JJ cord-014516-r59usk02 25 39 therapy therapy NN cord-014516-r59usk02 25 40 alone alone RB cord-014516-r59usk02 25 41 . . . cord-014516-r59usk02 26 1 No no DT cord-014516-r59usk02 26 2 conflicts conflict NNS cord-014516-r59usk02 26 3 of of IN cord-014516-r59usk02 26 4 interest interest NN cord-014516-r59usk02 26 5 reported report VBN cord-014516-r59usk02 26 6 . . . cord-014516-r59usk02 27 1 Canine canine JJ cord-014516-r59usk02 27 2 inflammatory inflammatory JJ cord-014516-r59usk02 27 3 bowel bowel NN cord-014516-r59usk02 27 4 disease disease NN cord-014516-r59usk02 27 5 ( ( -LRB- cord-014516-r59usk02 27 6 IBD IBD NNP cord-014516-r59usk02 27 7 ) ) -RRB- cord-014516-r59usk02 27 8 is be VBZ cord-014516-r59usk02 27 9 an an DT cord-014516-r59usk02 27 10 immune immune NN cord-014516-r59usk02 27 11 - - HYPH cord-014516-r59usk02 27 12 mediated mediate VBN cord-014516-r59usk02 27 13 enteropathy enteropathy NN cord-014516-r59usk02 27 14 likely likely RB cord-014516-r59usk02 27 15 triggered trigger VBN cord-014516-r59usk02 27 16 by by IN cord-014516-r59usk02 27 17 environmental environmental JJ cord-014516-r59usk02 27 18 and and CC cord-014516-r59usk02 27 19 immunoregulatory immunoregulatory JJ cord-014516-r59usk02 27 20 factors factor NNS cord-014516-r59usk02 27 21 in in IN cord-014516-r59usk02 27 22 genetically genetically RB cord-014516-r59usk02 27 23 susceptible susceptible JJ cord-014516-r59usk02 27 24 dogs dog NNS cord-014516-r59usk02 27 25 . . . cord-014516-r59usk02 28 1 Previous previous JJ cord-014516-r59usk02 28 2 studies study NNS cord-014516-r59usk02 28 3 suggest suggest VBP cord-014516-r59usk02 28 4 a a DT cord-014516-r59usk02 28 5 pivotal pivotal JJ cord-014516-r59usk02 28 6 role role NN cord-014516-r59usk02 28 7 for for IN cord-014516-r59usk02 28 8 gut gut NN cord-014516-r59usk02 28 9 bacteria bacteria NNS cord-014516-r59usk02 28 10 in in IN cord-014516-r59usk02 28 11 disease disease NN cord-014516-r59usk02 28 12 pathogenesis pathogenesis NN cord-014516-r59usk02 28 13 since since IN cord-014516-r59usk02 28 14 luminal luminal JJ cord-014516-r59usk02 28 15 microbial microbial JJ cord-014516-r59usk02 28 16 composition composition NN cord-014516-r59usk02 28 17 is be VBZ cord-014516-r59usk02 28 18 markedly markedly RB cord-014516-r59usk02 28 19 altered alter VBN cord-014516-r59usk02 28 20 ( ( -LRB- cord-014516-r59usk02 28 21 ie ie FW cord-014516-r59usk02 28 22 , , , cord-014516-r59usk02 28 23 dysbiosis dysbiosis NN cord-014516-r59usk02 28 24 ) ) -RRB- cord-014516-r59usk02 28 25 at at IN cord-014516-r59usk02 28 26 diagnosis diagnosis NN cord-014516-r59usk02 28 27 . . . cord-014516-r59usk02 29 1 Probiotic probiotic JJ cord-014516-r59usk02 29 2 bacteria bacteria NNS cord-014516-r59usk02 29 3 appear appear VBP cord-014516-r59usk02 29 4 to to TO cord-014516-r59usk02 29 5 be be VB cord-014516-r59usk02 29 6 therapeutically therapeutically RB cord-014516-r59usk02 29 7 effective effective JJ cord-014516-r59usk02 29 8 in in IN cord-014516-r59usk02 29 9 some some DT cord-014516-r59usk02 29 10 forms form NNS cord-014516-r59usk02 29 11 of of IN cord-014516-r59usk02 29 12 human human JJ cord-014516-r59usk02 29 13 IBD IBD NNP cord-014516-r59usk02 29 14 . . . cord-014516-r59usk02 30 1 Controlled control VBN cord-014516-r59usk02 30 2 studies study NNS cord-014516-r59usk02 30 3 evaluating evaluate VBG cord-014516-r59usk02 30 4 the the DT cord-014516-r59usk02 30 5 efficacy efficacy NN cord-014516-r59usk02 30 6 of of IN cord-014516-r59usk02 30 7 probiotic probiotic JJ cord-014516-r59usk02 30 8 therapy therapy NN cord-014516-r59usk02 30 9 for for IN cord-014516-r59usk02 30 10 canine canine JJ cord-014516-r59usk02 30 11 IBD IBD NNP cord-014516-r59usk02 30 12 have have VBP cord-014516-r59usk02 30 13 not not RB cord-014516-r59usk02 30 14 been be VBN cord-014516-r59usk02 30 15 previously previously RB cord-014516-r59usk02 30 16 reported report VBN cord-014516-r59usk02 30 17 . . . cord-014516-r59usk02 31 1 The the DT cord-014516-r59usk02 31 2 aim aim NN cord-014516-r59usk02 31 3 of of IN cord-014516-r59usk02 31 4 the the DT cord-014516-r59usk02 31 5 present present JJ cord-014516-r59usk02 31 6 study study NN cord-014516-r59usk02 31 7 was be VBD cord-014516-r59usk02 31 8 to to TO cord-014516-r59usk02 31 9 characterize characterize VB cord-014516-r59usk02 31 10 the the DT cord-014516-r59usk02 31 11 mucosa mucosa NN cord-014516-r59usk02 31 12 - - HYPH cord-014516-r59usk02 31 13 associated associate VBN cord-014516-r59usk02 31 14 microbiota microbiota NN cord-014516-r59usk02 31 15 and and CC cord-014516-r59usk02 31 16 determine determine VB cord-014516-r59usk02 31 17 the the DT cord-014516-r59usk02 31 18 clinical clinical JJ cord-014516-r59usk02 31 19 , , , cord-014516-r59usk02 31 20 microbiological microbiological JJ cord-014516-r59usk02 31 21 , , , cord-014516-r59usk02 31 22 and and CC cord-014516-r59usk02 31 23 mucosal mucosal JJ cord-014516-r59usk02 31 24 homeostatic homeostatic JJ cord-014516-r59usk02 31 25 effects effect NNS cord-014516-r59usk02 31 26 of of IN cord-014516-r59usk02 31 27 orally orally RB cord-014516-r59usk02 31 28 administered administer VBN cord-014516-r59usk02 31 29 VSL#3 VSL#3 NNP cord-014516-r59usk02 31 30 probiotics probiotic NNS cord-014516-r59usk02 31 31 in in IN cord-014516-r59usk02 31 32 dogs dog NNS cord-014516-r59usk02 31 33 with with IN cord-014516-r59usk02 31 34 IBD IBD NNP cord-014516-r59usk02 31 35 . . . cord-014516-r59usk02 32 1 Twenty twenty CD cord-014516-r59usk02 32 2 dogs dog NNS cord-014516-r59usk02 32 3 diagnosed diagnose VBN cord-014516-r59usk02 32 4 with with IN cord-014516-r59usk02 32 5 moderate moderate JJ cord-014516-r59usk02 32 6 - - HYPH cord-014516-r59usk02 32 7 to to IN cord-014516-r59usk02 32 8 - - HYPH cord-014516-r59usk02 32 9 severe severe JJ cord-014516-r59usk02 32 10 IBD IBD NNP cord-014516-r59usk02 32 11 ( ( -LRB- cord-014516-r59usk02 32 12 CIBDAI CIBDAI NNP cord-014516-r59usk02 32 13 score score NN cord-014516-r59usk02 32 14 > > XX cord-014516-r59usk02 32 15 5 5 CD cord-014516-r59usk02 32 16 ) ) -RRB- cord-014516-r59usk02 32 17 were be VBD cord-014516-r59usk02 32 18 randomized randomize VBN cord-014516-r59usk02 32 19 to to TO cord-014516-r59usk02 32 20 receive receive VB cord-014516-r59usk02 32 21 standard standard JJ cord-014516-r59usk02 32 22 therapy therapy NN cord-014516-r59usk02 32 23 ( ( -LRB- cord-014516-r59usk02 32 24 ie ie FW cord-014516-r59usk02 32 25 , , , cord-014516-r59usk02 32 26 elimination elimination NN cord-014516-r59usk02 32 27 diet diet NN cord-014516-r59usk02 32 28 and and CC cord-014516-r59usk02 32 29 glucocorticoids glucocorticoid NNS cord-014516-r59usk02 32 30 ) ) -RRB- cord-014516-r59usk02 32 31 with with IN cord-014516-r59usk02 32 32 or or CC cord-014516-r59usk02 32 33 without without IN cord-014516-r59usk02 32 34 probiotic probiotic JJ cord-014516-r59usk02 32 35 VSL#3 vsl#3 CD cord-014516-r59usk02 32 36 . . . cord-014516-r59usk02 33 1 The the DT cord-014516-r59usk02 33 2 mucosal mucosal JJ cord-014516-r59usk02 33 3 microbiota microbiota NN cord-014516-r59usk02 33 4 from from IN cord-014516-r59usk02 33 5 endoscopic endoscopic JJ cord-014516-r59usk02 33 6 intestinal intestinal JJ cord-014516-r59usk02 33 7 biopsies biopsy NNS cord-014516-r59usk02 33 8 of of IN cord-014516-r59usk02 33 9 IBD IBD NNP cord-014516-r59usk02 33 10 dogs dog NNS cord-014516-r59usk02 33 11 and and CC cord-014516-r59usk02 33 12 controls control NNS cord-014516-r59usk02 33 13 was be VBD cord-014516-r59usk02 33 14 evaluated evaluate VBN cord-014516-r59usk02 33 15 by by IN cord-014516-r59usk02 33 16 fluorescence fluorescence NN cord-014516-r59usk02 33 17 in in IN cord-014516-r59usk02 33 18 situ situ NN cord-014516-r59usk02 33 19 hybridization hybridization NN cord-014516-r59usk02 33 20 ( ( -LRB- cord-014516-r59usk02 33 21 FISH fish NN cord-014516-r59usk02 33 22 ) ) -RRB- cord-014516-r59usk02 33 23 targeting target VBG cord-014516-r59usk02 33 24 the the DT cord-014516-r59usk02 33 25 16S 16S NNPS cord-014516-r59usk02 33 26 rRNA rRNA NNP cord-014516-r59usk02 33 27 genes gene NNS cord-014516-r59usk02 33 28 of of IN cord-014516-r59usk02 33 29 total total JJ cord-014516-r59usk02 33 30 bacteria bacteria NNS cord-014516-r59usk02 33 31 , , , cord-014516-r59usk02 33 32 group group NN cord-014516-r59usk02 33 33 - - HYPH cord-014516-r59usk02 33 34 specific specific JJ cord-014516-r59usk02 33 35 organisms organism NNS cord-014516-r59usk02 33 36 , , , cord-014516-r59usk02 33 37 and and CC cord-014516-r59usk02 33 38 individual individual JJ cord-014516-r59usk02 33 39 bacterial bacterial JJ cord-014516-r59usk02 33 40 species specie NNS cord-014516-r59usk02 33 41 shown show VBN cord-014516-r59usk02 33 42 to to TO cord-014516-r59usk02 33 43 be be VB cord-014516-r59usk02 33 44 relevant relevant JJ cord-014516-r59usk02 33 45 in in IN cord-014516-r59usk02 33 46 human human JJ cord-014516-r59usk02 33 47 IBD IBD NNP cord-014516-r59usk02 33 48 . . . cord-014516-r59usk02 34 1 Epithelial epithelial JJ cord-014516-r59usk02 34 2 tight tight JJ cord-014516-r59usk02 34 3 junction junction NN cord-014516-r59usk02 34 4 protein protein NN cord-014516-r59usk02 34 5 ( ( -LRB- cord-014516-r59usk02 34 6 TJP TJP NNP cord-014516-r59usk02 34 7 ) ) -RRB- cord-014516-r59usk02 34 8 expression expression NN cord-014516-r59usk02 34 9 was be VBD cord-014516-r59usk02 34 10 studied study VBN cord-014516-r59usk02 34 11 using use VBG cord-014516-r59usk02 34 12 immunohistochemistry immunohistochemistry NN cord-014516-r59usk02 34 13 . . . cord-014516-r59usk02 35 1 Clinical clinical JJ cord-014516-r59usk02 35 2 signs sign NNS cord-014516-r59usk02 35 3 and and CC cord-014516-r59usk02 35 4 changes change NNS cord-014516-r59usk02 35 5 in in IN cord-014516-r59usk02 35 6 mucosal mucosal JJ cord-014516-r59usk02 35 7 microbiota microbiota NN cord-014516-r59usk02 35 8 and and CC cord-014516-r59usk02 35 9 TJP TJP NNP cord-014516-r59usk02 35 10 expression expression NN cord-014516-r59usk02 35 11 were be VBD cord-014516-r59usk02 35 12 assessed assess VBN cord-014516-r59usk02 35 13 before before RB cord-014516-r59usk02 35 14 and and CC cord-014516-r59usk02 35 15 after after IN cord-014516-r59usk02 35 16 probiotic probiotic JJ cord-014516-r59usk02 35 17 VSL#3 VSL#3 NNP cord-014516-r59usk02 35 18 therapy therapy NN cord-014516-r59usk02 35 19 . . . cord-014516-r59usk02 36 1 IBD IBD NNP cord-014516-r59usk02 36 2 dogs dog NNS cord-014516-r59usk02 36 3 showed show VBD cord-014516-r59usk02 36 4 a a DT cord-014516-r59usk02 36 5 reduction reduction NN cord-014516-r59usk02 36 6 in in IN cord-014516-r59usk02 36 7 GI GI NNP cord-014516-r59usk02 36 8 signs sign NNS cord-014516-r59usk02 36 9 following follow VBG cord-014516-r59usk02 36 10 8 8 CD cord-014516-r59usk02 36 11 weeks week NNS cord-014516-r59usk02 36 12 of of IN cord-014516-r59usk02 36 13 probiotic probiotic JJ cord-014516-r59usk02 36 14 therapy therapy NN cord-014516-r59usk02 36 15 compared compare VBN cord-014516-r59usk02 36 16 with with IN cord-014516-r59usk02 36 17 baseline baseline JJ cord-014516-r59usk02 36 18 CIBDAI CIBDAI NNP cord-014516-r59usk02 36 19 scores score NNS cord-014516-r59usk02 36 20 ( ( -LRB- cord-014516-r59usk02 36 21 P p NN cord-014516-r59usk02 36 22 < < XX cord-014516-r59usk02 36 23 0.05 0.05 CD cord-014516-r59usk02 36 24 ) ) -RRB- cord-014516-r59usk02 36 25 . . . cord-014516-r59usk02 37 1 Adherent adherent JJ cord-014516-r59usk02 37 2 and and CC cord-014516-r59usk02 37 3 sporadic sporadic JJ cord-014516-r59usk02 37 4 invasive invasive JJ cord-014516-r59usk02 37 5 bacteria bacteria NNS cord-014516-r59usk02 37 6 ( ( -LRB- cord-014516-r59usk02 37 7 EUB EUB NNP cord-014516-r59usk02 37 8 ) ) -RRB- cord-014516-r59usk02 37 9 were be VBD cord-014516-r59usk02 37 10 observed observe VBN cord-014516-r59usk02 37 11 in in IN cord-014516-r59usk02 37 12 the the DT cord-014516-r59usk02 37 13 small small JJ cord-014516-r59usk02 37 14 intestines intestine NNS cord-014516-r59usk02 37 15 and and CC cord-014516-r59usk02 37 16 colon colon NN cord-014516-r59usk02 37 17 of of IN cord-014516-r59usk02 37 18 healthy healthy JJ cord-014516-r59usk02 37 19 dogs dog NNS cord-014516-r59usk02 37 20 . . . cord-014516-r59usk02 38 1 The the DT cord-014516-r59usk02 38 2 diseased diseased JJ cord-014516-r59usk02 38 3 canine canine JJ cord-014516-r59usk02 38 4 duodenum duodenum NN cord-014516-r59usk02 38 5 was be VBD cord-014516-r59usk02 38 6 nearly nearly RB cord-014516-r59usk02 38 7 bacteria bacteria NNS cord-014516-r59usk02 38 8 - - HYPH cord-014516-r59usk02 38 9 free free JJ cord-014516-r59usk02 38 10 . . . cord-014516-r59usk02 39 1 IBD IBD NNP cord-014516-r59usk02 39 2 dogs dog NNS cord-014516-r59usk02 39 3 given give VBN cord-014516-r59usk02 39 4 probiotic probiotic JJ cord-014516-r59usk02 39 5 VSL vsl NN cord-014516-r59usk02 39 6 # # NN cord-014516-r59usk02 39 7 3 3 CD cord-014516-r59usk02 39 8 had have VBD cord-014516-r59usk02 39 9 altered alter VBN cord-014516-r59usk02 39 10 spatial spatial JJ cord-014516-r59usk02 39 11 redistribution redistribution NN cord-014516-r59usk02 39 12 of of IN cord-014516-r59usk02 39 13 most most JJS cord-014516-r59usk02 39 14 bacterial bacterial JJ cord-014516-r59usk02 39 15 groups group NNS cord-014516-r59usk02 39 16 in in IN cord-014516-r59usk02 39 17 the the DT cord-014516-r59usk02 39 18 mucus mucus NN cord-014516-r59usk02 39 19 and and CC cord-014516-r59usk02 39 20 adherent adherent JJ cord-014516-r59usk02 39 21 compartments compartment NNS cord-014516-r59usk02 39 22 of of IN cord-014516-r59usk02 39 23 the the DT cord-014516-r59usk02 39 24 colon colon NN cord-014516-r59usk02 39 25 . . . cord-014516-r59usk02 40 1 Subset subset JJ cord-014516-r59usk02 40 2 analysis analysis NN cord-014516-r59usk02 40 3 showed show VBD cord-014516-r59usk02 40 4 that that IN cord-014516-r59usk02 40 5 Lactobacilli Lactobacilli NNP cord-014516-r59usk02 40 6 were be VBD cord-014516-r59usk02 40 7 significantly significantly RB cord-014516-r59usk02 40 8 ( ( -LRB- cord-014516-r59usk02 40 9 P p NN cord-014516-r59usk02 40 10 < < XX cord-014516-r59usk02 40 11 0.05 0.05 CD cord-014516-r59usk02 40 12 ) ) -RRB- cord-014516-r59usk02 40 13 increased increase VBD cord-014516-r59usk02 40 14 in in IN cord-014516-r59usk02 40 15 the the DT cord-014516-r59usk02 40 16 lumen lumen NN cord-014516-r59usk02 40 17 and and CC cord-014516-r59usk02 40 18 mucus mucus NN cord-014516-r59usk02 40 19 post post JJ cord-014516-r59usk02 40 20 - - JJ cord-014516-r59usk02 40 21 VSL VSL NNP cord-014516-r59usk02 40 22 # # NN cord-014516-r59usk02 40 23 3 3 CD cord-014516-r59usk02 40 24 , , , cord-014516-r59usk02 40 25 while while IN cord-014516-r59usk02 40 26 the the DT cord-014516-r59usk02 40 27 number number NN cord-014516-r59usk02 40 28 of of IN cord-014516-r59usk02 40 29 mucus mucus NN cord-014516-r59usk02 40 30 laden laden NNP cord-014516-r59usk02 40 31 Bifidobacteria Bifidobacteria NNP cord-014516-r59usk02 40 32 approached approach VBD cord-014516-r59usk02 40 33 significance significance NN cord-014516-r59usk02 40 34 ( ( -LRB- cord-014516-r59usk02 40 35 P p NN cord-014516-r59usk02 40 36 = = SYM cord-014516-r59usk02 40 37 0.08 0.08 CD cord-014516-r59usk02 40 38 ) ) -RRB- cord-014516-r59usk02 40 39 . . . cord-014516-r59usk02 41 1 Expression expression NN cord-014516-r59usk02 41 2 of of IN cord-014516-r59usk02 41 3 TJP TJP NNP cord-014516-r59usk02 41 4 showed show VBD cord-014516-r59usk02 41 5 that that IN cord-014516-r59usk02 41 6 occludin occludin NNP cord-014516-r59usk02 41 7 was be VBD cord-014516-r59usk02 41 8 significantly significantly RB cord-014516-r59usk02 41 9 lower low JJR cord-014516-r59usk02 41 10 in in IN cord-014516-r59usk02 41 11 control control NN cord-014516-r59usk02 41 12 intestines intestine NNS cord-014516-r59usk02 41 13 as as IN cord-014516-r59usk02 41 14 compared compare VBN cord-014516-r59usk02 41 15 to to IN cord-014516-r59usk02 41 16 duodenal duodenal JJ cord-014516-r59usk02 41 17 and and CC cord-014516-r59usk02 41 18 colonic colonic JJ cord-014516-r59usk02 41 19 mucosa mucosa NN cord-014516-r59usk02 41 20 obtained obtain VBN cord-014516-r59usk02 41 21 from from IN cord-014516-r59usk02 41 22 IBD IBD NNP cord-014516-r59usk02 41 23 dogs dog NNS cord-014516-r59usk02 41 24 that that WDT cord-014516-r59usk02 41 25 received receive VBD cord-014516-r59usk02 41 26 probiotic probiotic NN cord-014516-r59usk02 41 27 ( ( -LRB- cord-014516-r59usk02 41 28 P p NN cord-014516-r59usk02 41 29 = = SYM cord-014516-r59usk02 41 30 0.008 0.008 CD cord-014516-r59usk02 41 31 and and CC cord-014516-r59usk02 41 32 P p NN cord-014516-r59usk02 41 33 = = SYM cord-014516-r59usk02 41 34 0.01 0.01 CD cord-014516-r59usk02 41 35 , , , cord-014516-r59usk02 41 36 respectively respectively RB cord-014516-r59usk02 41 37 ) ) -RRB- cord-014516-r59usk02 41 38 . . . cord-014516-r59usk02 42 1 In in IN cord-014516-r59usk02 42 2 contrast contrast NN cord-014516-r59usk02 42 3 , , , cord-014516-r59usk02 42 4 claudin-2 claudin-2 NNP cord-014516-r59usk02 42 5 expression expression NN cord-014516-r59usk02 42 6 in in IN cord-014516-r59usk02 42 7 the the DT cord-014516-r59usk02 42 8 colon colon NN cord-014516-r59usk02 42 9 was be VBD cord-014516-r59usk02 42 10 significantly significantly RB cord-014516-r59usk02 42 11 higher high JJR cord-014516-r59usk02 42 12 ( ( -LRB- cord-014516-r59usk02 42 13 P p NN cord-014516-r59usk02 42 14 < < XX cord-014516-r59usk02 42 15 0.002 0.002 CD cord-014516-r59usk02 42 16 ) ) -RRB- cord-014516-r59usk02 42 17 in in IN cord-014516-r59usk02 42 18 control control NN cord-014516-r59usk02 42 19 dogs dog NNS cord-014516-r59usk02 42 20 versus versus IN cord-014516-r59usk02 42 21 VSL VSL NNP cord-014516-r59usk02 42 22 # # NNP cord-014516-r59usk02 42 23 3 3 CD cord-014516-r59usk02 42 24 treated treat VBD cord-014516-r59usk02 42 25 IBD IBD NNP cord-014516-r59usk02 42 26 dogs dog NNS cord-014516-r59usk02 42 27 . . . cord-014516-r59usk02 43 1 Our -PRON- PRP$ cord-014516-r59usk02 43 2 data datum NNS cord-014516-r59usk02 43 3 demonstrate demonstrate VBP cord-014516-r59usk02 43 4 that that IN cord-014516-r59usk02 43 5 probiotic probiotic NN cord-014516-r59usk02 43 6 VSL#3 VSL#3 NNP cord-014516-r59usk02 43 7 alters alter VBZ cord-014516-r59usk02 43 8 some some DT cord-014516-r59usk02 43 9 of of IN cord-014516-r59usk02 43 10 the the DT cord-014516-r59usk02 43 11 mucosa mucosa NN cord-014516-r59usk02 43 12 - - HYPH cord-014516-r59usk02 43 13 associated associate VBN cord-014516-r59usk02 43 14 microbiota microbiota NN cord-014516-r59usk02 43 15 in in IN cord-014516-r59usk02 43 16 dogs dog NNS cord-014516-r59usk02 43 17 with with IN cord-014516-r59usk02 43 18 IBD IBD NNP cord-014516-r59usk02 43 19 . . . cord-014516-r59usk02 44 1 These these DT cord-014516-r59usk02 44 2 probiotic probiotic JJ cord-014516-r59usk02 44 3 changes change NNS cord-014516-r59usk02 44 4 in in IN cord-014516-r59usk02 44 5 bacterial bacterial JJ cord-014516-r59usk02 44 6 composition composition NN cord-014516-r59usk02 44 7 are be VBP cord-014516-r59usk02 44 8 associated associate VBN cord-014516-r59usk02 44 9 with with IN cord-014516-r59usk02 44 10 up up RB cord-014516-r59usk02 44 11 - - HYPH cord-014516-r59usk02 44 12 regulated regulate VBN cord-014516-r59usk02 44 13 TJP TJP NNP cord-014516-r59usk02 44 14 expression expression NN cord-014516-r59usk02 44 15 indicative indicative JJ cord-014516-r59usk02 44 16 of of IN cord-014516-r59usk02 44 17 enhanced enhanced JJ cord-014516-r59usk02 44 18 epithelial epithelial JJ cord-014516-r59usk02 44 19 barrier barrier NN cord-014516-r59usk02 44 20 integrity integrity NN cord-014516-r59usk02 44 21 , , , cord-014516-r59usk02 44 22 similar similar JJ cord-014516-r59usk02 44 23 to to IN cord-014516-r59usk02 44 24 VSL#3-induced VSL#3-induced NNP cord-014516-r59usk02 44 25 disease disease NN cord-014516-r59usk02 44 26 protection protection NN cord-014516-r59usk02 44 27 seen see VBN cord-014516-r59usk02 44 28 in in IN cord-014516-r59usk02 44 29 human human JJ cord-014516-r59usk02 44 30 IBD IBD NNP cord-014516-r59usk02 44 31 . . . cord-014516-r59usk02 45 1 The the DT cord-014516-r59usk02 45 2 probiotics probiotic NNS cord-014516-r59usk02 45 3 used use VBN cord-014516-r59usk02 45 4 in in IN cord-014516-r59usk02 45 5 the the DT cord-014516-r59usk02 45 6 trial trial NN cord-014516-r59usk02 45 7 were be VBD cord-014516-r59usk02 45 8 supplied supply VBN cord-014516-r59usk02 45 9 free free JJ cord-014516-r59usk02 45 10 of of IN cord-014516-r59usk02 45 11 charge charge NN cord-014516-r59usk02 45 12 by by IN cord-014516-r59usk02 45 13 the the DT cord-014516-r59usk02 45 14 manufacturer manufacturer NN cord-014516-r59usk02 45 15 . . . cord-014516-r59usk02 46 1 Canine canine JJ cord-014516-r59usk02 46 2 Inflammatory inflammatory JJ cord-014516-r59usk02 46 3 bowel bowel NN cord-014516-r59usk02 46 4 disease disease NN cord-014516-r59usk02 46 5 ( ( -LRB- cord-014516-r59usk02 46 6 IBD IBD NNP cord-014516-r59usk02 46 7 ) ) -RRB- cord-014516-r59usk02 46 8 is be VBZ cord-014516-r59usk02 46 9 thought think VBN cord-014516-r59usk02 46 10 to to TO cord-014516-r59usk02 46 11 be be VB cord-014516-r59usk02 46 12 partially partially RB cord-014516-r59usk02 46 13 caused cause VBN cord-014516-r59usk02 46 14 by by IN cord-014516-r59usk02 46 15 an an DT cord-014516-r59usk02 46 16 aberrant aberrant JJ cord-014516-r59usk02 46 17 immune immune JJ cord-014516-r59usk02 46 18 response response NN cord-014516-r59usk02 46 19 towards towards IN cord-014516-r59usk02 46 20 the the DT cord-014516-r59usk02 46 21 intestinal intestinal JJ cord-014516-r59usk02 46 22 microbiome microbiome NN cord-014516-r59usk02 46 23 . . . cord-014516-r59usk02 47 1 In in IN cord-014516-r59usk02 47 2 humans human NNS cord-014516-r59usk02 47 3 and and CC cord-014516-r59usk02 47 4 mice mouse NNS cord-014516-r59usk02 47 5 , , , cord-014516-r59usk02 47 6 administration administration NN cord-014516-r59usk02 47 7 of of IN cord-014516-r59usk02 47 8 probiotics probiotic NNS cord-014516-r59usk02 47 9 can can MD cord-014516-r59usk02 47 10 alleviate alleviate VB cord-014516-r59usk02 47 11 IBD IBD NNP cord-014516-r59usk02 47 12 severity severity NN cord-014516-r59usk02 47 13 and/or and/or CC cord-014516-r59usk02 47 14 prevent prevent VB cord-014516-r59usk02 47 15 relapse relapse NN cord-014516-r59usk02 47 16 by by IN cord-014516-r59usk02 47 17 induction induction NN cord-014516-r59usk02 47 18 of of IN cord-014516-r59usk02 47 19 a a DT cord-014516-r59usk02 47 20 more more RBR cord-014516-r59usk02 47 21 " " '' cord-014516-r59usk02 47 22 tolerant"microenvironment tolerant"microenvironment . cord-014516-r59usk02 47 23 . . . cord-014516-r59usk02 48 1 The the DT cord-014516-r59usk02 48 2 aim aim NN cord-014516-r59usk02 48 3 of of IN cord-014516-r59usk02 48 4 this this DT cord-014516-r59usk02 48 5 study study NN cord-014516-r59usk02 48 6 was be VBD cord-014516-r59usk02 48 7 to to TO cord-014516-r59usk02 48 8 investigate investigate VB cord-014516-r59usk02 48 9 the the DT cord-014516-r59usk02 48 10 effect effect NN cord-014516-r59usk02 48 11 of of IN cord-014516-r59usk02 48 12 probiotic probiotic JJ cord-014516-r59usk02 48 13 Enterococcus Enterococcus NNP cord-014516-r59usk02 48 14 faecium faecium NN cord-014516-r59usk02 48 15 NCIMB NCIMB NNP cord-014516-r59usk02 49 1 10415 10415 CD cord-014516-r59usk02 49 2 E1707 E1707 NNP cord-014516-r59usk02 49 3 ( ( -LRB- cord-014516-r59usk02 49 4 EF EF NNP cord-014516-r59usk02 49 5 ) ) -RRB- cord-014516-r59usk02 49 6 on on IN cord-014516-r59usk02 49 7 intestinal intestinal JJ cord-014516-r59usk02 49 8 microbiome microbiome NN cord-014516-r59usk02 49 9 composition composition NN cord-014516-r59usk02 49 10 . . . cord-014516-r59usk02 50 1 Dogs dog NNS cord-014516-r59usk02 50 2 were be VBD cord-014516-r59usk02 50 3 recruited recruit VBN cord-014516-r59usk02 50 4 to to TO cord-014516-r59usk02 50 5 receive receive VB cord-014516-r59usk02 50 6 EF EF NNP cord-014516-r59usk02 50 7 at at IN cord-014516-r59usk02 50 8 1x10e8 1x10e8 NNP cord-014516-r59usk02 50 9 cfu cfu NNS cord-014516-r59usk02 50 10 in in IN cord-014516-r59usk02 50 11 a a DT cord-014516-r59usk02 50 12 double double RB cord-014516-r59usk02 50 13 - - HYPH cord-014516-r59usk02 50 14 blinded blinded JJ cord-014516-r59usk02 50 15 , , , cord-014516-r59usk02 50 16 placebo placebo NN cord-014516-r59usk02 50 17 - - HYPH cord-014516-r59usk02 50 18 controlled control VBN cord-014516-r59usk02 50 19 manner manner NN cord-014516-r59usk02 50 20 in in IN cord-014516-r59usk02 50 21 addition addition NN cord-014516-r59usk02 50 22 to to IN cord-014516-r59usk02 50 23 an an DT cord-014516-r59usk02 50 24 exclusion exclusion NN cord-014516-r59usk02 50 25 diet diet NN cord-014516-r59usk02 50 26 ( ( -LRB- cord-014516-r59usk02 50 27 hydrolysed hydrolysed JJ cord-014516-r59usk02 50 28 protein protein NN cord-014516-r59usk02 50 29 ) ) -RRB- cord-014516-r59usk02 50 30 . . . cord-014516-r59usk02 51 1 Seven seven CD cord-014516-r59usk02 51 2 dogs dog NNS cord-014516-r59usk02 51 3 were be VBD cord-014516-r59usk02 51 4 included include VBN cord-014516-r59usk02 51 5 in in IN cord-014516-r59usk02 51 6 the the DT cord-014516-r59usk02 51 7 probiotics probiotic NNS cord-014516-r59usk02 51 8 group group NN cord-014516-r59usk02 51 9 and and CC cord-014516-r59usk02 51 10 5 5 CD cord-014516-r59usk02 51 11 dogs dog NNS cord-014516-r59usk02 51 12 in in IN cord-014516-r59usk02 51 13 the the DT cord-014516-r59usk02 51 14 placebo placebo NN cord-014516-r59usk02 51 15 group group NN cord-014516-r59usk02 51 16 . . . cord-014516-r59usk02 52 1 All all DT cord-014516-r59usk02 52 2 dogs dog NNS cord-014516-r59usk02 52 3 improved improve VBD cord-014516-r59usk02 52 4 clinically clinically RB cord-014516-r59usk02 52 5 after after IN cord-014516-r59usk02 52 6 treatment treatment NN cord-014516-r59usk02 52 7 , , , cord-014516-r59usk02 52 8 however however RB cord-014516-r59usk02 52 9 , , , cord-014516-r59usk02 52 10 there there EX cord-014516-r59usk02 52 11 was be VBD cord-014516-r59usk02 52 12 no no DT cord-014516-r59usk02 52 13 obvious obvious JJ cord-014516-r59usk02 52 14 effect effect NN cord-014516-r59usk02 52 15 on on IN cord-014516-r59usk02 52 16 clinical clinical JJ cord-014516-r59usk02 52 17 severity severity NN cord-014516-r59usk02 52 18 in in IN cord-014516-r59usk02 52 19 those those DT cord-014516-r59usk02 52 20 that that WDT cord-014516-r59usk02 52 21 received receive VBD cord-014516-r59usk02 52 22 probiotics probiotic NNS cord-014516-r59usk02 52 23 . . . cord-014516-r59usk02 53 1 Fresh fresh JJ cord-014516-r59usk02 53 2 naturally naturally RB cord-014516-r59usk02 53 3 voided void VBD cord-014516-r59usk02 53 4 faecal faecal JJ cord-014516-r59usk02 53 5 samples sample NNS cord-014516-r59usk02 53 6 were be VBD cord-014516-r59usk02 53 7 collected collect VBN cord-014516-r59usk02 53 8 from from IN cord-014516-r59usk02 53 9 all all DT cord-014516-r59usk02 53 10 dogs dog NNS cord-014516-r59usk02 53 11 before before RB cord-014516-r59usk02 53 12 and and CC cord-014516-r59usk02 53 13 after after IN cord-014516-r59usk02 53 14 treatment treatment NN cord-014516-r59usk02 53 15 , , , cord-014516-r59usk02 53 16 snap snap NN cord-014516-r59usk02 53 17 - - HYPH cord-014516-r59usk02 53 18 frozen frozen JJ cord-014516-r59usk02 53 19 in in IN cord-014516-r59usk02 53 20 liquid liquid JJ cord-014516-r59usk02 53 21 nitrogen nitrogen NN cord-014516-r59usk02 53 22 and and CC cord-014516-r59usk02 53 23 stored store VBN cord-014516-r59usk02 53 24 at at IN cord-014516-r59usk02 53 25 -80 -80 NNP cord-014516-r59usk02 53 26 ° ° NN cord-014516-r59usk02 53 27 C C NNP cord-014516-r59usk02 53 28 until until IN cord-014516-r59usk02 53 29 further further JJ cord-014516-r59usk02 53 30 analysis analysis NN cord-014516-r59usk02 53 31 . . . cord-014516-r59usk02 54 1 Genomic genomic JJ cord-014516-r59usk02 54 2 DNA dna NN cord-014516-r59usk02 54 3 was be VBD cord-014516-r59usk02 54 4 extracted extract VBN cord-014516-r59usk02 54 5 from from IN cord-014516-r59usk02 54 6 each each DT cord-014516-r59usk02 54 7 faecal faecal JJ cord-014516-r59usk02 54 8 sample sample NN cord-014516-r59usk02 54 9 using use VBG cord-014516-r59usk02 54 10 the the DT cord-014516-r59usk02 54 11 Mobio Mobio NNP cord-014516-r59usk02 54 12 Power Power NNP cord-014516-r59usk02 54 13 soil soil NN cord-014516-r59usk02 54 14 DNA dna NN cord-014516-r59usk02 54 15 isolation isolation NN cord-014516-r59usk02 54 16 Kit kit NN cord-014516-r59usk02 54 17 ( ( -LRB- cord-014516-r59usk02 54 18 MoBio MoBio NNP cord-014516-r59usk02 54 19 Laboratories Laboratories NNPS cord-014516-r59usk02 54 20 ) ) -RRB- cord-014516-r59usk02 54 21 , , , cord-014516-r59usk02 54 22 as as IN cord-014516-r59usk02 54 23 recommended recommend VBN cord-014516-r59usk02 54 24 by by IN cord-014516-r59usk02 54 25 the the DT cord-014516-r59usk02 54 26 manufacturer manufacturer NN cord-014516-r59usk02 54 27 . . . cord-014516-r59usk02 55 1 Next next JJ cord-014516-r59usk02 55 2 generation generation NN cord-014516-r59usk02 55 3 sequencing sequencing NN cord-014516-r59usk02 55 4 was be VBD cord-014516-r59usk02 55 5 performed perform VBN cord-014516-r59usk02 55 6 on on IN cord-014516-r59usk02 55 7 the the DT cord-014516-r59usk02 55 8 Ion Ion NNP cord-014516-r59usk02 55 9 - - HYPH cord-014516-r59usk02 55 10 Torrent[TRADEMARK Torrent[TRADEMARK NNP cord-014516-r59usk02 55 11 ] ] -RRB- cord-014516-r59usk02 56 1 ( ( -LRB- cord-014516-r59usk02 56 2 Life Life NNP cord-014516-r59usk02 56 3 Technologies Technologies NNPS cord-014516-r59usk02 56 4 ) ) -RRB- cord-014516-r59usk02 56 5 platform platform NN cord-014516-r59usk02 56 6 based base VBN cord-014516-r59usk02 56 7 upon upon IN cord-014516-r59usk02 56 8 the the DT cord-014516-r59usk02 56 9 V1-V3 V1-V3 NNP cord-014516-r59usk02 56 10 region region NN cord-014516-r59usk02 56 11 ( ( -LRB- cord-014516-r59usk02 56 12 E. E. NNP cord-014516-r59usk02 56 13 coli coli NNS cord-014516-r59usk02 56 14 position position NN cord-014516-r59usk02 56 15 27 27 CD cord-014516-r59usk02 56 16 - - SYM cord-014516-r59usk02 56 17 519 519 CD cord-014516-r59usk02 56 18 ) ) -RRB- cord-014516-r59usk02 56 19 of of IN cord-014516-r59usk02 56 20 the the DT cord-014516-r59usk02 56 21 16S 16S NNP cord-014516-r59usk02 56 22 rRNA rrna NN cord-014516-r59usk02 56 23 gene gene NN cord-014516-r59usk02 56 24 with with IN cord-014516-r59usk02 56 25 the the DT cord-014516-r59usk02 56 26 following follow VBG cord-014516-r59usk02 56 27 primers primer NNS cord-014516-r59usk02 56 28 : : : cord-014516-r59usk02 56 29 forward forward RB cord-014516-r59usk02 56 30 28F 28f CD cord-014516-r59usk02 56 31 : : : cord-014516-r59usk02 56 32 GAG gag NN cord-014516-r59usk02 56 33 - - HYPH cord-014516-r59usk02 56 34 TTTGATCNTGGCTCAG tttgatcntggctcag NN cord-014516-r59usk02 56 35 and and CC cord-014516-r59usk02 56 36 reverse reverse VB cord-014516-r59usk02 56 37 519R 519r CD cord-014516-r59usk02 56 38 : : : cord-014516-r59usk02 56 39 GTNTTACN GTNTTACN NNP cord-014516-r59usk02 56 40 GCGGCKGCTG GCGGCKGCTG NNP cord-014516-r59usk02 56 41 . . . cord-014516-r59usk02 57 1 Raw raw JJ cord-014516-r59usk02 57 2 sequence sequence NN cord-014516-r59usk02 57 3 data datum NNS cord-014516-r59usk02 57 4 were be VBD cord-014516-r59usk02 57 5 screened screen VBN cord-014516-r59usk02 57 6 , , , cord-014516-r59usk02 57 7 trimmed trim VBN cord-014516-r59usk02 57 8 , , , cord-014516-r59usk02 57 9 filtered filter VBN cord-014516-r59usk02 57 10 , , , cord-014516-r59usk02 57 11 and and CC cord-014516-r59usk02 57 12 chimera chimera NN cord-014516-r59usk02 57 13 depleted deplete VBN cord-014516-r59usk02 57 14 with with IN cord-014516-r59usk02 57 15 default default NN cord-014516-r59usk02 57 16 settings setting NNS cord-014516-r59usk02 57 17 using use VBG cord-014516-r59usk02 57 18 the the DT cord-014516-r59usk02 57 19 QIIME QIIME NNP cord-014516-r59usk02 57 20 pipeline pipeline NN cord-014516-r59usk02 57 21 version version NN cord-014516-r59usk02 57 22 1.8 1.8 CD cord-014516-r59usk02 57 23 and and CC cord-014516-r59usk02 57 24 UCHIME UCHIME NNP cord-014516-r59usk02 57 25 software software NN cord-014516-r59usk02 57 26 , , , cord-014516-r59usk02 57 27 in in IN cord-014516-r59usk02 57 28 which which WDT cord-014516-r59usk02 57 29 microbiome microbiome NN cord-014516-r59usk02 57 30 composition composition NN cord-014516-r59usk02 57 31 between between IN cord-014516-r59usk02 57 32 treatment treatment NN cord-014516-r59usk02 57 33 groups group NNS cord-014516-r59usk02 57 34 before before IN cord-014516-r59usk02 57 35 and and CC cord-014516-r59usk02 57 36 after after IN cord-014516-r59usk02 57 37 treatment treatment NN cord-014516-r59usk02 57 38 was be VBD cord-014516-r59usk02 57 39 compared compare VBN cord-014516-r59usk02 57 40 . . . cord-014516-r59usk02 58 1 Microbiota Microbiota NNP cord-014516-r59usk02 58 2 composition composition NN cord-014516-r59usk02 58 3 was be VBD cord-014516-r59usk02 58 4 not not RB cord-014516-r59usk02 58 5 significantly significantly RB cord-014516-r59usk02 58 6 different different JJ cord-014516-r59usk02 58 7 between between IN cord-014516-r59usk02 58 8 probiotic probiotic NN cord-014516-r59usk02 58 9 and and CC cord-014516-r59usk02 58 10 placebo placebo NN cord-014516-r59usk02 58 11 treatment treatment NN cord-014516-r59usk02 58 12 groups group NNS cord-014516-r59usk02 58 13 , , , cord-014516-r59usk02 58 14 and and CC cord-014516-r59usk02 58 15 did do VBD cord-014516-r59usk02 58 16 not not RB cord-014516-r59usk02 58 17 change change VB cord-014516-r59usk02 58 18 significantly significantly RB cord-014516-r59usk02 58 19 before before IN cord-014516-r59usk02 58 20 and and CC cord-014516-r59usk02 58 21 after after IN cord-014516-r59usk02 58 22 treatment treatment NN cord-014516-r59usk02 58 23 . . . cord-014516-r59usk02 59 1 However however RB cord-014516-r59usk02 59 2 , , , cord-014516-r59usk02 59 3 there there EX cord-014516-r59usk02 59 4 was be VBD cord-014516-r59usk02 59 5 large large JJ cord-014516-r59usk02 59 6 individual individual JJ cord-014516-r59usk02 59 7 variability variability NN cord-014516-r59usk02 59 8 in in IN cord-014516-r59usk02 59 9 the the DT cord-014516-r59usk02 59 10 microbiome microbiome NN cord-014516-r59usk02 59 11 composition composition NN cord-014516-r59usk02 59 12 . . . cord-014516-r59usk02 60 1 Species specie NNS cord-014516-r59usk02 60 2 richness richness NN cord-014516-r59usk02 60 3 of of IN cord-014516-r59usk02 60 4 faecal faecal JJ cord-014516-r59usk02 60 5 samples sample NNS cord-014516-r59usk02 60 6 increased increase VBD cord-014516-r59usk02 60 7 after after IN cord-014516-r59usk02 60 8 treatment treatment NN cord-014516-r59usk02 60 9 in in IN cord-014516-r59usk02 60 10 both both DT cord-014516-r59usk02 60 11 groups group NNS cord-014516-r59usk02 60 12 , , , cord-014516-r59usk02 60 13 but but CC cord-014516-r59usk02 60 14 was be VBD cord-014516-r59usk02 60 15 only only RB cord-014516-r59usk02 60 16 statistically statistically RB cord-014516-r59usk02 60 17 significant significant JJ cord-014516-r59usk02 60 18 in in IN cord-014516-r59usk02 60 19 the the DT cord-014516-r59usk02 60 20 probiotic probiotic JJ cord-014516-r59usk02 60 21 treatment treatment NN cord-014516-r59usk02 60 22 group group NN cord-014516-r59usk02 60 23 . . . cord-014516-r59usk02 61 1 In in IN cord-014516-r59usk02 61 2 conclusion conclusion NN cord-014516-r59usk02 61 3 , , , cord-014516-r59usk02 61 4 probiotic probiotic JJ cord-014516-r59usk02 61 5 treatment treatment NN cord-014516-r59usk02 61 6 in in IN cord-014516-r59usk02 61 7 dogs dog NNS cord-014516-r59usk02 61 8 with with IN cord-014516-r59usk02 61 9 IBD IBD NNP cord-014516-r59usk02 61 10 leads lead VBZ cord-014516-r59usk02 61 11 to to IN cord-014516-r59usk02 61 12 a a DT cord-014516-r59usk02 61 13 significantly significantly RB cord-014516-r59usk02 61 14 increased increase VBN cord-014516-r59usk02 61 15 richness richness NN cord-014516-r59usk02 61 16 of of IN cord-014516-r59usk02 61 17 the the DT cord-014516-r59usk02 61 18 faecal faecal JJ cord-014516-r59usk02 61 19 bacterial bacterial JJ cord-014516-r59usk02 61 20 microbiome microbiome NN cord-014516-r59usk02 61 21 . . . cord-014516-r59usk02 62 1 A a DT cord-014516-r59usk02 62 2 possible possible JJ cord-014516-r59usk02 62 3 additional additional JJ cord-014516-r59usk02 62 4 effect effect NN cord-014516-r59usk02 62 5 of of IN cord-014516-r59usk02 62 6 the the DT cord-014516-r59usk02 62 7 change change NN cord-014516-r59usk02 62 8 of of IN cord-014516-r59usk02 62 9 diet diet NN cord-014516-r59usk02 62 10 can can MD cord-014516-r59usk02 62 11 not not RB cord-014516-r59usk02 62 12 be be VB cord-014516-r59usk02 62 13 excluded exclude VBN cord-014516-r59usk02 62 14 . . . cord-014516-r59usk02 63 1 Further further JJ cord-014516-r59usk02 63 2 studies study NNS cord-014516-r59usk02 63 3 should should MD cord-014516-r59usk02 63 4 investigate investigate VB cord-014516-r59usk02 63 5 microbiomic microbiomic JJ cord-014516-r59usk02 63 6 changes change NNS cord-014516-r59usk02 63 7 in in IN cord-014516-r59usk02 63 8 healthy healthy JJ cord-014516-r59usk02 63 9 dogs dog NNS cord-014516-r59usk02 63 10 fed feed VBD cord-014516-r59usk02 63 11 the the DT cord-014516-r59usk02 63 12 same same JJ cord-014516-r59usk02 63 13 diet diet NN cord-014516-r59usk02 63 14 to to TO cord-014516-r59usk02 63 15 assess assess VB cord-014516-r59usk02 63 16 if if IN cord-014516-r59usk02 63 17 similar similar JJ cord-014516-r59usk02 63 18 changes change NNS cord-014516-r59usk02 63 19 in in IN cord-014516-r59usk02 63 20 the the DT cord-014516-r59usk02 63 21 fecal fecal JJ cord-014516-r59usk02 63 22 microbiome microbiome NN cord-014516-r59usk02 63 23 occur occur VBP cord-014516-r59usk02 63 24 due due JJ cord-014516-r59usk02 63 25 to to IN cord-014516-r59usk02 63 26 dietary dietary JJ cord-014516-r59usk02 63 27 changes change NNS cord-014516-r59usk02 63 28 alone alone RB cord-014516-r59usk02 63 29 . . . cord-014516-r59usk02 64 1 This this DT cord-014516-r59usk02 64 2 study study NN cord-014516-r59usk02 64 3 is be VBZ cord-014516-r59usk02 64 4 based base VBN cord-014516-r59usk02 64 5 on on IN cord-014516-r59usk02 64 6 a a DT cord-014516-r59usk02 64 7 PhD phd NN cord-014516-r59usk02 64 8 supported support VBN cord-014516-r59usk02 64 9 by by IN cord-014516-r59usk02 64 10 Probiotics Probiotics NNP cord-014516-r59usk02 64 11 Ltd. Ltd. NNP cord-014516-r59usk02 64 12 , , , cord-014516-r59usk02 64 13 Somerset Somerset NNP cord-014516-r59usk02 64 14 , , , cord-014516-r59usk02 64 15 UK UK NNP cord-014516-r59usk02 64 16 ( ( -LRB- cord-014516-r59usk02 64 17 the the DT cord-014516-r59usk02 64 18 manufacturer manufacturer NN cord-014516-r59usk02 64 19 of of IN cord-014516-r59usk02 64 20 the the DT cord-014516-r59usk02 64 21 probiotic probiotic JJ cord-014516-r59usk02 64 22 product product NN cord-014516-r59usk02 64 23 Enterococcus Enterococcus NNP cord-014516-r59usk02 64 24 faecium faecium NN cord-014516-r59usk02 64 25 mentioned mention VBN cord-014516-r59usk02 64 26 in in IN cord-014516-r59usk02 64 27 this this DT cord-014516-r59usk02 64 28 study study NN cord-014516-r59usk02 64 29 ) ) -RRB- cord-014516-r59usk02 64 30 . . . cord-014516-r59usk02 65 1 The the DT cord-014516-r59usk02 65 2 aim aim NN cord-014516-r59usk02 65 3 of of IN cord-014516-r59usk02 65 4 this this DT cord-014516-r59usk02 65 5 study study NN cord-014516-r59usk02 65 6 was be VBD cord-014516-r59usk02 65 7 to to TO cord-014516-r59usk02 65 8 assess assess VB cord-014516-r59usk02 65 9 the the DT cord-014516-r59usk02 65 10 prevalence prevalence NN cord-014516-r59usk02 65 11 and and CC cord-014516-r59usk02 65 12 risk risk NN cord-014516-r59usk02 65 13 factors factor NNS cord-014516-r59usk02 65 14 for for IN cord-014516-r59usk02 65 15 faecal faecal JJ cord-014516-r59usk02 65 16 carriage carriage NN cord-014516-r59usk02 65 17 of of IN cord-014516-r59usk02 65 18 extended extended JJ cord-014516-r59usk02 65 19 - - HYPH cord-014516-r59usk02 65 20 spectrum spectrum NN cord-014516-r59usk02 65 21 beta beta NN cord-014516-r59usk02 65 22 - - HYPH cord-014516-r59usk02 65 23 lactamases lactamase NNS cord-014516-r59usk02 65 24 ( ( -LRB- cord-014516-r59usk02 65 25 ESBL ESBL NNP cord-014516-r59usk02 65 26 ) ) -RRB- cord-014516-r59usk02 65 27 and and CC cord-014516-r59usk02 65 28 plasmidic plasmidic NNP cord-014516-r59usk02 65 29 AmpC AmpC NNP cord-014516-r59usk02 65 30 beta beta NN cord-014516-r59usk02 65 31 - - HYPH cord-014516-r59usk02 65 32 lactamases lactamase NNS cord-014516-r59usk02 65 33 ( ( -LRB- cord-014516-r59usk02 65 34 pAmpC pampc NN cord-014516-r59usk02 65 35 ) ) -RRB- cord-014516-r59usk02 65 36 E. E. NNP cord-014516-r59usk02 65 37 coliproducers coliproducer NNS cord-014516-r59usk02 65 38 in in IN cord-014516-r59usk02 65 39 healthy healthy JJ cord-014516-r59usk02 65 40 dogs dog NNS cord-014516-r59usk02 65 41 . . . cord-014516-r59usk02 66 1 A a DT cord-014516-r59usk02 66 2 3-month 3-month CD cord-014516-r59usk02 66 3 cross cross JJ cord-014516-r59usk02 66 4 - - JJ cord-014516-r59usk02 66 5 sectional sectional JJ cord-014516-r59usk02 66 6 study study NN cord-014516-r59usk02 66 7 was be VBD cord-014516-r59usk02 66 8 conducted conduct VBN cord-014516-r59usk02 66 9 at at IN cord-014516-r59usk02 66 10 a a DT cord-014516-r59usk02 66 11 private private JJ cord-014516-r59usk02 66 12 hospital hospital NN cord-014516-r59usk02 66 13 in in IN cord-014516-r59usk02 66 14 Lisbon Lisbon NNP cord-014516-r59usk02 66 15 , , , cord-014516-r59usk02 66 16 Portugal Portugal NNP cord-014516-r59usk02 66 17 and and CC cord-014516-r59usk02 66 18 151 151 CD cord-014516-r59usk02 66 19 rectal rectal JJ cord-014516-r59usk02 66 20 swabs swab NNS cord-014516-r59usk02 66 21 were be VBD cord-014516-r59usk02 66 22 obtained obtain VBN cord-014516-r59usk02 66 23 from from IN cord-014516-r59usk02 66 24 healthy healthy JJ cord-014516-r59usk02 66 25 dogs dog NNS cord-014516-r59usk02 66 26 . . . cord-014516-r59usk02 67 1 The the DT cord-014516-r59usk02 67 2 dogs dog NNS cord-014516-r59usk02 67 3 included include VBD cord-014516-r59usk02 67 4 in in IN cord-014516-r59usk02 67 5 the the DT cord-014516-r59usk02 67 6 study study NN cord-014516-r59usk02 67 7 were be VBD cord-014516-r59usk02 67 8 healthy healthy JJ cord-014516-r59usk02 67 9 with with IN cord-014516-r59usk02 67 10 no no DT cord-014516-r59usk02 67 11 history history NN cord-014516-r59usk02 67 12 of of IN cord-014516-r59usk02 67 13 antimicrobial antimicrobial JJ cord-014516-r59usk02 67 14 consumption consumption NN cord-014516-r59usk02 67 15 in in IN cord-014516-r59usk02 67 16 the the DT cord-014516-r59usk02 67 17 previous previous JJ cord-014516-r59usk02 67 18 month month NN cord-014516-r59usk02 67 19 . . . cord-014516-r59usk02 68 1 ESBL ESBL NNP cord-014516-r59usk02 68 2 and and CC cord-014516-r59usk02 68 3 pAmpC pampc NN cord-014516-r59usk02 68 4 genes gene NNS cord-014516-r59usk02 68 5 were be VBD cord-014516-r59usk02 68 6 detected detect VBN cord-014516-r59usk02 68 7 by by IN cord-014516-r59usk02 68 8 PCR PCR NNP cord-014516-r59usk02 68 9 and and CC cord-014516-r59usk02 68 10 were be VBD cord-014516-r59usk02 68 11 sequenced sequence VBN cord-014516-r59usk02 68 12 . . . cord-014516-r59usk02 69 1 Potential potential JJ cord-014516-r59usk02 69 2 risk risk NN cord-014516-r59usk02 69 3 factors factor NNS cord-014516-r59usk02 69 4 for for IN cord-014516-r59usk02 69 5 ESBL ESBL NNP cord-014516-r59usk02 69 6 - - : cord-014516-r59usk02 69 7 and and CC cord-014516-r59usk02 69 8 pAmpC pampc NN cord-014516-r59usk02 69 9 - - HYPH cord-014516-r59usk02 69 10 producing produce VBG cord-014516-r59usk02 69 11 E. E. NNP cord-014516-r59usk02 69 12 coli coli NNS cord-014516-r59usk02 69 13 faecal faecal JJ cord-014516-r59usk02 69 14 carriage carriage NN cord-014516-r59usk02 69 15 were be VBD cord-014516-r59usk02 69 16 obtained obtain VBN cord-014516-r59usk02 69 17 through through IN cord-014516-r59usk02 69 18 a a DT cord-014516-r59usk02 69 19 questionnaire questionnaire NN cord-014516-r59usk02 69 20 to to IN cord-014516-r59usk02 69 21 the the DT cord-014516-r59usk02 69 22 owner owner NN cord-014516-r59usk02 69 23 regarding regard VBG cord-014516-r59usk02 69 24 reason reason NN cord-014516-r59usk02 69 25 for for IN cord-014516-r59usk02 69 26 veterinary veterinary JJ cord-014516-r59usk02 69 27 visit visit NN cord-014516-r59usk02 69 28 , , , cord-014516-r59usk02 69 29 hospitalisation hospitalisation NN cord-014516-r59usk02 69 30 and and CC cord-014516-r59usk02 69 31 antimicrobial antimicrobial JJ cord-014516-r59usk02 69 32 treatment treatment NN cord-014516-r59usk02 69 33 within within IN cord-014516-r59usk02 69 34 the the DT cord-014516-r59usk02 69 35 last last JJ cord-014516-r59usk02 69 36 year year NN cord-014516-r59usk02 69 37 , , , cord-014516-r59usk02 69 38 habitat habitat NN cord-014516-r59usk02 69 39 ( ( -LRB- cord-014516-r59usk02 69 40 shelter shelter NN cord-014516-r59usk02 69 41 , , , cord-014516-r59usk02 69 42 dog dog NN cord-014516-r59usk02 69 43 breeders breeder NNS cord-014516-r59usk02 69 44 and and CC cord-014516-r59usk02 69 45 private private JJ cord-014516-r59usk02 69 46 owner owner NN cord-014516-r59usk02 69 47 ) ) -RRB- cord-014516-r59usk02 69 48 , , , cord-014516-r59usk02 69 49 cohabitation cohabitation NN cord-014516-r59usk02 69 50 with with IN cord-014516-r59usk02 69 51 other other JJ cord-014516-r59usk02 69 52 animals animal NNS cord-014516-r59usk02 69 53 , , , cord-014516-r59usk02 69 54 street street NN cord-014516-r59usk02 69 55 access access NN cord-014516-r59usk02 69 56 , , , cord-014516-r59usk02 69 57 kennel kennel NN cord-014516-r59usk02 69 58 / / SYM cord-014516-r59usk02 69 59 hotel hotel NN cord-014516-r59usk02 69 60 access access NN cord-014516-r59usk02 69 61 , , , cord-014516-r59usk02 69 62 age age NN cord-014516-r59usk02 69 63 and and CC cord-014516-r59usk02 69 64 gender gender NN cord-014516-r59usk02 69 65 . . . cord-014516-r59usk02 70 1 Data datum NNS cord-014516-r59usk02 70 2 were be VBD cord-014516-r59usk02 70 3 analysed analyse VBN cord-014516-r59usk02 70 4 by by IN cord-014516-r59usk02 70 5 SAS SAS NNP cord-014516-r59usk02 70 6 software software NN cord-014516-r59usk02 70 7 ( ( -LRB- cord-014516-r59usk02 70 8 version version NN cord-014516-r59usk02 70 9 9.3 9.3 CD cord-014516-r59usk02 70 10 ; ; : cord-014516-r59usk02 70 11 SAS SAS NNP cord-014516-r59usk02 70 12 Institute Institute NNP cord-014516-r59usk02 70 13 Inc. Inc. NNP cord-014516-r59usk02 70 14 , , , cord-014516-r59usk02 70 15 Cary Cary NNP cord-014516-r59usk02 70 16 , , , cord-014516-r59usk02 70 17 N.C. North Carolina NNP cord-014516-r59usk02 70 18 ) ) -RRB- cord-014516-r59usk02 70 19 and and CC cord-014516-r59usk02 70 20 logistic logistic JJ cord-014516-r59usk02 70 21 regression regression NN cord-014516-r59usk02 70 22 models model NNS cord-014516-r59usk02 70 23 were be VBD cord-014516-r59usk02 70 24 used use VBN cord-014516-r59usk02 70 25 . . . cord-014516-r59usk02 71 1 Rectal rectal JJ cord-014516-r59usk02 71 2 swabs swab NNS cord-014516-r59usk02 71 3 obtained obtain VBN cord-014516-r59usk02 71 4 from from IN cord-014516-r59usk02 71 5 151 151 CD cord-014516-r59usk02 71 6 healthy healthy JJ cord-014516-r59usk02 71 7 dogs dog NNS cord-014516-r59usk02 71 8 yielded yield VBD cord-014516-r59usk02 71 9 131 131 CD cord-014516-r59usk02 71 10 positive positive JJ cord-014516-r59usk02 71 11 samples sample NNS cord-014516-r59usk02 71 12 for for IN cord-014516-r59usk02 71 13 E. E. NNP cord-014516-r59usk02 71 14 coli coli NNS cord-014516-r59usk02 71 15 . . . cord-014516-r59usk02 72 1 About about RB cord-014516-r59usk02 72 2 15 15 CD cord-014516-r59usk02 72 3 % % NN cord-014516-r59usk02 72 4 of of IN cord-014516-r59usk02 72 5 the the DT cord-014516-r59usk02 72 6 isolates isolate NNS cord-014516-r59usk02 72 7 carried carry VBD cord-014516-r59usk02 72 8 ESBL ESBL NNP cord-014516-r59usk02 72 9 genes gene NNS cord-014516-r59usk02 72 10 ( ( -LRB- cord-014516-r59usk02 72 11 bla bla NNP cord-014516-r59usk02 72 12 CTX CTX NNP cord-014516-r59usk02 72 13 - - HYPH cord-014516-r59usk02 72 14 M-32 M-32 NNP cord-014516-r59usk02 72 15 n n CC cord-014516-r59usk02 72 16 = = SYM cord-014516-r59usk02 72 17 8 8 CD cord-014516-r59usk02 72 18 , , , cord-014516-r59usk02 72 19 bla bla NNP cord-014516-r59usk02 72 20 CTX CTX NNP cord-014516-r59usk02 72 21 - - HYPH cord-014516-r59usk02 72 22 M-15 M-15 NNP cord-014516-r59usk02 72 23 n n NN cord-014516-r59usk02 72 24 = = SYM cord-014516-r59usk02 72 25 5 5 CD cord-014516-r59usk02 72 26 , , , cord-014516-r59usk02 72 27 bla bla NNP cord-014516-r59usk02 72 28 CTX CTX NNP cord-014516-r59usk02 72 29 - - HYPH cord-014516-r59usk02 72 30 M-1 M-1 NNP cord-014516-r59usk02 72 31 n n NNP cord-014516-r59usk02 72 32 = = SYM cord-014516-r59usk02 72 33 3 3 CD cord-014516-r59usk02 72 34 , , , cord-014516-r59usk02 72 35 bla bla NNP cord-014516-r59usk02 72 36 CTX CTX NNP cord-014516-r59usk02 72 37 - - HYPH cord-014516-r59usk02 72 38 M-9-like M-9-like NNP cord-014516-r59usk02 72 39 n n CC cord-014516-r59usk02 72 40 = = SYM cord-014516-r59usk02 72 41 4 4 CD cord-014516-r59usk02 72 42 ) ) -RRB- cord-014516-r59usk02 72 43 and and CC cord-014516-r59usk02 72 44 20 20 CD cord-014516-r59usk02 72 45 % % NN cord-014516-r59usk02 72 46 carried carry VBN cord-014516-r59usk02 72 47 pAmpC pampc NN cord-014516-r59usk02 72 48 genes gene NNS cord-014516-r59usk02 73 1 ( ( -LRB- cord-014516-r59usk02 73 2 bla bla NNP cord-014516-r59usk02 73 3 CMY-2 CMY-2 NNP cord-014516-r59usk02 73 4 n n CC cord-014516-r59usk02 73 5 = = NN cord-014516-r59usk02 74 1 23 23 CD cord-014516-r59usk02 74 2 , , , cord-014516-r59usk02 74 3 bla bla NNP cord-014516-r59usk02 74 4 CMY-2-like CMY-2-like NNP cord-014516-r59usk02 74 5 n n NN cord-014516-r59usk02 74 6 = = SYM cord-014516-r59usk02 74 7 2 2 CD cord-014516-r59usk02 74 8 , , , cord-014516-r59usk02 74 9 bla bla NNP cord-014516-r59usk02 75 1 DHA-1 DHA-1 NNP cord-014516-r59usk02 75 2 n n NN cord-014516-r59usk02 75 3 = = SYM cord-014516-r59usk02 75 4 1 1 CD cord-014516-r59usk02 75 5 ) ) -RRB- cord-014516-r59usk02 75 6 . . . cord-014516-r59usk02 76 1 Thirteen thirteen CD cord-014516-r59usk02 76 2 dogs dog NNS cord-014516-r59usk02 76 3 carried carry VBD cord-014516-r59usk02 76 4 an an DT cord-014516-r59usk02 76 5 E. E. NNP cord-014516-r59usk02 76 6 coli coli NNS cord-014516-r59usk02 76 7 isolate isolate VB cord-014516-r59usk02 76 8 with with IN cord-014516-r59usk02 76 9 both both CC cord-014516-r59usk02 76 10 an an DT cord-014516-r59usk02 76 11 ESBL ESBL NNP cord-014516-r59usk02 76 12 and and CC cord-014516-r59usk02 76 13 a a DT cord-014516-r59usk02 76 14 pAmpC pampc NN cord-014516-r59usk02 76 15 gene gene NN cord-014516-r59usk02 76 16 . . . cord-014516-r59usk02 77 1 Dogs dog NNS cord-014516-r59usk02 77 2 previously previously RB cord-014516-r59usk02 77 3 treated treat VBN cord-014516-r59usk02 77 4 with with IN cord-014516-r59usk02 77 5 antimicrobials antimicrobial NNS cord-014516-r59usk02 77 6 within within IN cord-014516-r59usk02 77 7 the the DT cord-014516-r59usk02 77 8 last last JJ cord-014516-r59usk02 77 9 year year NN cord-014516-r59usk02 77 10 were be VBD cord-014516-r59usk02 77 11 at at IN cord-014516-r59usk02 77 12 higher high JJR cord-014516-r59usk02 77 13 risk risk NN cord-014516-r59usk02 77 14 of of IN cord-014516-r59usk02 77 15 carrying carry VBG cord-014516-r59usk02 77 16 at at RB cord-014516-r59usk02 77 17 least least RBS cord-014516-r59usk02 77 18 one one CD cord-014516-r59usk02 77 19 ß ß NN cord-014516-r59usk02 77 20 - - HYPH cord-014516-r59usk02 77 21 lactamase lactamase NN cord-014516-r59usk02 77 22 ( ( -LRB- cord-014516-r59usk02 77 23 P p NN cord-014516-r59usk02 77 24 = = SYM cord-014516-r59usk02 77 25 0.003 0.003 CD cord-014516-r59usk02 77 26 ; ; : cord-014516-r59usk02 77 27 OR or CC cord-014516-r59usk02 77 28 = = SYM cord-014516-r59usk02 77 29 7.85 7.85 CD cord-014516-r59usk02 77 30 ; ; : cord-014516-r59usk02 78 1 CI CI NNP cord-014516-r59usk02 78 2 95 95 CD cord-014516-r59usk02 78 3 % % NN cord-014516-r59usk02 78 4 : : : cord-014516-r59usk02 78 5 1.99 1.99 CD cord-014516-r59usk02 78 6 - - SYM cord-014516-r59usk02 78 7 30.89 30.89 CD cord-014516-r59usk02 78 8 ) ) -RRB- cord-014516-r59usk02 78 9 or or CC cord-014516-r59usk02 78 10 both both DT cord-014516-r59usk02 78 11 ß ß NN cord-014516-r59usk02 78 12 - - HYPH cord-014516-r59usk02 78 13 lactamases lactamase NNS cord-014516-r59usk02 78 14 ( ( -LRB- cord-014516-r59usk02 78 15 P p NN cord-014516-r59usk02 78 16 = = SYM cord-014516-r59usk02 78 17 0.020 0.020 CD cord-014516-r59usk02 78 18 ; ; : cord-014516-r59usk02 78 19 OR or CC cord-014516-r59usk02 78 20 = = SYM cord-014516-r59usk02 78 21 5.18 5.18 CD cord-014516-r59usk02 78 22 ; ; : cord-014516-r59usk02 78 23 CI CI NNP cord-014516-r59usk02 78 24 95 95 CD cord-014516-r59usk02 78 25 % % NN cord-014516-r59usk02 78 26 : : : cord-014516-r59usk02 78 27 1.29 1.29 CD cord-014516-r59usk02 78 28 - - SYM cord-014516-r59usk02 78 29 20.81 20.81 CD cord-014516-r59usk02 78 30 ) ) -RRB- cord-014516-r59usk02 78 31 than than IN cord-014516-r59usk02 78 32 non non JJ cord-014516-r59usk02 78 33 - - JJ cord-014516-r59usk02 78 34 treated treat VBN cord-014516-r59usk02 78 35 dogs dog NNS cord-014516-r59usk02 78 36 . . . cord-014516-r59usk02 79 1 Dogs dog NNS cord-014516-r59usk02 79 2 in in IN cord-014516-r59usk02 79 3 shelters shelter NNS cord-014516-r59usk02 79 4 / / SYM cord-014516-r59usk02 79 5 breeders breeder NNS cord-014516-r59usk02 79 6 tended tend VBD cord-014516-r59usk02 79 7 to to TO cord-014516-r59usk02 79 8 show show VB cord-014516-r59usk02 79 9 a a DT cord-014516-r59usk02 79 10 higher high JJR cord-014516-r59usk02 79 11 incidence incidence NN cord-014516-r59usk02 79 12 of of IN cord-014516-r59usk02 79 13 ESBL ESBL NNP cord-014516-r59usk02 79 14 - - HYPH cord-014516-r59usk02 79 15 producing produce VBG cord-014516-r59usk02 79 16 E. E. NNP cord-014516-r59usk02 79 17 coli coli NNS cord-014516-r59usk02 79 18 ( ( -LRB- cord-014516-r59usk02 79 19 P p NN cord-014516-r59usk02 79 20 = = SYM cord-014516-r59usk02 79 21 0.069 0.069 CD cord-014516-r59usk02 79 22 ; ; : cord-014516-r59usk02 79 23 OR or CC cord-014516-r59usk02 79 24 = = SYM cord-014516-r59usk02 79 25 3.17 3.17 CD cord-014516-r59usk02 79 26 ; ; : cord-014516-r59usk02 79 27 CI CI NNP cord-014516-r59usk02 79 28 95 95 CD cord-014516-r59usk02 79 29 % % NN cord-014516-r59usk02 79 30 : : : cord-014516-r59usk02 79 31 0.91 0.91 CD cord-014516-r59usk02 79 32 - - SYM cord-014516-r59usk02 79 33 11.01 11.01 CD cord-014516-r59usk02 79 34 ) ) -RRB- cord-014516-r59usk02 79 35 or or CC cord-014516-r59usk02 79 36 at at IN cord-014516-r59usk02 79 37 least least JJS cord-014516-r59usk02 79 38 one one CD cord-014516-r59usk02 79 39 ß ß NN cord-014516-r59usk02 79 40 - - HYPH cord-014516-r59usk02 79 41 lactamase lactamase NN cord-014516-r59usk02 79 42 producing produce VBG cord-014516-r59usk02 79 43 E. E. NNP cord-014516-r59usk02 79 44 coli coli NNS cord-014516-r59usk02 79 45 ( ( -LRB- cord-014516-r59usk02 79 46 P p NN cord-014516-r59usk02 79 47 = = SYM cord-014516-r59usk02 79 48 0.050 0.050 CD cord-014516-r59usk02 79 49 ; ; : cord-014516-r59usk02 79 50 OR or CC cord-014516-r59usk02 79 51 = = SYM cord-014516-r59usk02 79 52 2.65 2.65 CD cord-014516-r59usk02 79 53 ; ; : cord-014516-r59usk02 79 54 CI CI NNP cord-014516-r59usk02 79 55 95 95 CD cord-014516-r59usk02 79 56 % % NN cord-014516-r59usk02 79 57 : : : cord-014516-r59usk02 79 58 1.00 1.00 CD cord-014516-r59usk02 79 59 - - SYM cord-014516-r59usk02 79 60 7.03 7.03 CD cord-014516-r59usk02 79 61 ) ) -RRB- cord-014516-r59usk02 79 62 than than IN cord-014516-r59usk02 79 63 dogs dog NNS cord-014516-r59usk02 79 64 from from IN cord-014516-r59usk02 79 65 private private JJ cord-014516-r59usk02 79 66 owners owner NNS cord-014516-r59usk02 79 67 . . . cord-014516-r59usk02 80 1 Males male NNS cord-014516-r59usk02 80 2 tended tend VBD cord-014516-r59usk02 80 3 to to TO cord-014516-r59usk02 80 4 be be VB cord-014516-r59usk02 80 5 less less RBR cord-014516-r59usk02 80 6 likely likely JJ cord-014516-r59usk02 80 7 to to TO cord-014516-r59usk02 80 8 carry carry VB cord-014516-r59usk02 80 9 at at RB cord-014516-r59usk02 80 10 least least RBS cord-014516-r59usk02 80 11 one one CD cord-014516-r59usk02 80 12 ß ß NN cord-014516-r59usk02 80 13 - - HYPH cord-014516-r59usk02 80 14 lactamase lactamase NN cord-014516-r59usk02 80 15 ( ( -LRB- cord-014516-r59usk02 80 16 ESBL ESBL NNP cord-014516-r59usk02 80 17 or or CC cord-014516-r59usk02 80 18 pAmpC pampc NN cord-014516-r59usk02 80 19 ) ) -RRB- cord-014516-r59usk02 80 20 ( ( -LRB- cord-014516-r59usk02 80 21 P p NN cord-014516-r59usk02 80 22 = = SYM cord-014516-r59usk02 80 23 0.060 0.060 CD cord-014516-r59usk02 80 24 ; ; : cord-014516-r59usk02 80 25 OR or CC cord-014516-r59usk02 80 26 = = SYM cord-014516-r59usk02 80 27 0.42 0.42 CD cord-014516-r59usk02 80 28 ; ; . cord-014516-r59usk02 81 1 CI CI NNP cord-014516-r59usk02 81 2 95 95 CD cord-014516-r59usk02 81 3 % % NN cord-014516-r59usk02 81 4 : : : cord-014516-r59usk02 81 5 0.17 0.17 CD cord-014516-r59usk02 81 6 - - HYPH cord-014516-r59usk02 81 7 1.04 1.04 CD cord-014516-r59usk02 81 8 ) ) -RRB- cord-014516-r59usk02 81 9 or or CC cord-014516-r59usk02 81 10 a a DT cord-014516-r59usk02 81 11 pAmpC pampc NN cord-014516-r59usk02 81 12 enzyme enzyme NN cord-014516-r59usk02 81 13 ( ( -LRB- cord-014516-r59usk02 81 14 P p NN cord-014516-r59usk02 81 15 = = SYM cord-014516-r59usk02 81 16 0.017 0.017 CD cord-014516-r59usk02 81 17 ; ; : cord-014516-r59usk02 81 18 OR or CC cord-014516-r59usk02 81 19 = = NFP cord-014516-r59usk02 81 20 0.28 0.28 CD cord-014516-r59usk02 82 1 ; ; : cord-014516-r59usk02 82 2 CI CI NNP cord-014516-r59usk02 82 3 95 95 CD cord-014516-r59usk02 82 4 % % NN cord-014516-r59usk02 82 5 : : : cord-014516-r59usk02 82 6 0.10 0.10 CD cord-014516-r59usk02 82 7 - - HYPH cord-014516-r59usk02 82 8 0.80 0.80 CD cord-014516-r59usk02 82 9 ) ) -RRB- cord-014516-r59usk02 82 10 than than IN cord-014516-r59usk02 82 11 females female NNS cord-014516-r59usk02 82 12 . . . cord-014516-r59usk02 83 1 This this DT cord-014516-r59usk02 83 2 study study NN cord-014516-r59usk02 83 3 suggests suggest VBZ cord-014516-r59usk02 83 4 that that IN cord-014516-r59usk02 83 5 dogs dog NNS cord-014516-r59usk02 83 6 may may MD cord-014516-r59usk02 83 7 act act VB cord-014516-r59usk02 83 8 as as IN cord-014516-r59usk02 83 9 reservoirs reservoir NNS cord-014516-r59usk02 83 10 for for IN cord-014516-r59usk02 83 11 resistant resistant JJ cord-014516-r59usk02 83 12 bacteria bacteria NNS cord-014516-r59usk02 83 13 , , , cord-014516-r59usk02 83 14 namely namely RB cord-014516-r59usk02 83 15 for for IN cord-014516-r59usk02 83 16 cephalosporin cephalosporin NN cord-014516-r59usk02 83 17 - - HYPH cord-014516-r59usk02 83 18 resistant resistant JJ cord-014516-r59usk02 83 19 E. E. NNP cord-014516-r59usk02 83 20 coli coli NNS cord-014516-r59usk02 83 21 . . . cord-014516-r59usk02 84 1 Three three CD cord-014516-r59usk02 84 2 potential potential JJ cord-014516-r59usk02 84 3 risk risk NN cord-014516-r59usk02 84 4 factors factor NNS cord-014516-r59usk02 84 5 associated associate VBN cord-014516-r59usk02 84 6 with with IN cord-014516-r59usk02 84 7 the the DT cord-014516-r59usk02 84 8 carriage carriage NN cord-014516-r59usk02 84 9 of of IN cord-014516-r59usk02 84 10 ESBL ESBL NNP cord-014516-r59usk02 84 11 - - HYPH cord-014516-r59usk02 84 12 and and CC cord-014516-r59usk02 84 13 / / SYM cord-014516-r59usk02 84 14 or or CC cord-014516-r59usk02 84 15 pAmpC pampc RB cord-014516-r59usk02 84 16 - - HYPH cord-014516-r59usk02 84 17 producing produce VBG cord-014516-r59usk02 84 18 E. E. NNP cord-014516-r59usk02 84 19 coli coli NNS cord-014516-r59usk02 84 20 by by IN cord-014516-r59usk02 84 21 dogs dog NNS cord-014516-r59usk02 84 22 were be VBD cord-014516-r59usk02 84 23 identified identify VBN cord-014516-r59usk02 84 24 , , , cord-014516-r59usk02 84 25 which which WDT cord-014516-r59usk02 84 26 is be VBZ cord-014516-r59usk02 84 27 important important JJ cord-014516-r59usk02 84 28 for for IN cord-014516-r59usk02 84 29 the the DT cord-014516-r59usk02 84 30 implementation implementation NN cord-014516-r59usk02 84 31 of of IN cord-014516-r59usk02 84 32 effective effective JJ cord-014516-r59usk02 84 33 control control NN cord-014516-r59usk02 84 34 measures measure NNS cord-014516-r59usk02 84 35 and and CC cord-014516-r59usk02 84 36 judicious judicious JJ cord-014516-r59usk02 84 37 antimicrobial antimicrobial JJ cord-014516-r59usk02 84 38 therapy therapy NN cord-014516-r59usk02 84 39 . . . cord-014516-r59usk02 85 1 Conflicts conflict NNS cord-014516-r59usk02 85 2 of of IN cord-014516-r59usk02 85 3 interest interest NN cord-014516-r59usk02 85 4 : : : cord-014516-r59usk02 85 5 Dr Dr NNP cord-014516-r59usk02 85 6 Pomba Pomba NNP cord-014516-r59usk02 85 7 currently currently RB cord-014516-r59usk02 85 8 receives receive VBZ cord-014516-r59usk02 85 9 research research NN cord-014516-r59usk02 85 10 funding funding NN cord-014516-r59usk02 85 11 from from IN cord-014516-r59usk02 85 12 the the DT cord-014516-r59usk02 85 13 government government NN cord-014516-r59usk02 85 14 and and CC cord-014516-r59usk02 85 15 national national JJ cord-014516-r59usk02 85 16 programmes programme NNS cord-014516-r59usk02 85 17 ( ( -LRB- cord-014516-r59usk02 85 18 Fundac Fundac NNP cord-014516-r59usk02 85 19 ßão ßão NNS cord-014516-r59usk02 85 20 para para NNP cord-014516-r59usk02 85 21 a a DT cord-014516-r59usk02 85 22 Ciência Ciência NNP cord-014516-r59usk02 85 23 e e NN cord-014516-r59usk02 85 24 a a DT cord-014516-r59usk02 85 25 Tecnologia Tecnologia NNP cord-014516-r59usk02 85 26 ) ) -RRB- cord-014516-r59usk02 85 27 . . . cord-014516-r59usk02 86 1 In in IN cord-014516-r59usk02 86 2 the the DT cord-014516-r59usk02 86 3 past past NN cord-014516-r59usk02 86 4 , , , cord-014516-r59usk02 86 5 she -PRON- PRP cord-014516-r59usk02 86 6 has have VBZ cord-014516-r59usk02 86 7 occasionally occasionally RB cord-014516-r59usk02 86 8 received receive VBN cord-014516-r59usk02 86 9 research research NN cord-014516-r59usk02 86 10 support support NN cord-014516-r59usk02 86 11 or or CC cord-014516-r59usk02 86 12 honoraria honoraria NN cord-014516-r59usk02 86 13 for for IN cord-014516-r59usk02 86 14 lectures lecture NNS cord-014516-r59usk02 86 15 from from IN cord-014516-r59usk02 86 16 pharmaceutical pharmaceutical JJ cord-014516-r59usk02 86 17 companies company NNS cord-014516-r59usk02 86 18 including include VBG cord-014516-r59usk02 86 19 Zoetis Zoetis NNP cord-014516-r59usk02 86 20 and and CC cord-014516-r59usk02 86 21 Atral Atral NNP cord-014516-r59usk02 86 22 Cipan Cipan NNP cord-014516-r59usk02 86 23 . . . cord-014516-r59usk02 87 1 She -PRON- PRP cord-014516-r59usk02 87 2 is be VBZ cord-014516-r59usk02 87 3 vice vice NN cord-014516-r59usk02 87 4 - - HYPH cord-014516-r59usk02 87 5 chair chair NN cord-014516-r59usk02 87 6 of of IN cord-014516-r59usk02 87 7 the the DT cord-014516-r59usk02 87 8 Antimicrobial Antimicrobial NNP cord-014516-r59usk02 87 9 Working Working NNP cord-014516-r59usk02 87 10 Party Party NNP cord-014516-r59usk02 88 1 There there EX cord-014516-r59usk02 88 2 are be VBP cord-014516-r59usk02 88 3 few few JJ cord-014516-r59usk02 88 4 reports report NNS cord-014516-r59usk02 88 5 in in IN cord-014516-r59usk02 88 6 the the DT cord-014516-r59usk02 88 7 literature literature NN cord-014516-r59usk02 88 8 reporting report VBG cord-014516-r59usk02 88 9 long long JJ cord-014516-r59usk02 88 10 - - HYPH cord-014516-r59usk02 88 11 term term NN cord-014516-r59usk02 88 12 relapse relapse NN cord-014516-r59usk02 88 13 rate rate NN cord-014516-r59usk02 88 14 , , , cord-014516-r59usk02 88 15 owner owner NN cord-014516-r59usk02 88 16 compliance compliance NN cord-014516-r59usk02 88 17 and and CC cord-014516-r59usk02 88 18 clinical clinical JJ cord-014516-r59usk02 88 19 severity severity NN cord-014516-r59usk02 88 20 of of IN cord-014516-r59usk02 88 21 dogs dog NNS cord-014516-r59usk02 88 22 with with IN cord-014516-r59usk02 88 23 chronic chronic JJ cord-014516-r59usk02 88 24 enteropathies enteropathy NNS cord-014516-r59usk02 88 25 . . . cord-014516-r59usk02 89 1 The the DT cord-014516-r59usk02 89 2 goal goal NN cord-014516-r59usk02 89 3 of of IN cord-014516-r59usk02 89 4 this this DT cord-014516-r59usk02 89 5 study study NN cord-014516-r59usk02 89 6 was be VBD cord-014516-r59usk02 89 7 to to TO cord-014516-r59usk02 89 8 compare compare VB cord-014516-r59usk02 89 9 clinical clinical JJ cord-014516-r59usk02 89 10 activity activity NN cord-014516-r59usk02 89 11 index index NN cord-014516-r59usk02 89 12 ( ( -LRB- cord-014516-r59usk02 89 13 CCECAI CCECAI NNP cord-014516-r59usk02 89 14 ) ) -RRB- cord-014516-r59usk02 89 15 , , , cord-014516-r59usk02 89 16 number number NN cord-014516-r59usk02 89 17 of of IN cord-014516-r59usk02 89 18 relapses relapse NNS cord-014516-r59usk02 89 19 and and CC cord-014516-r59usk02 89 20 compliance compliance NN cord-014516-r59usk02 89 21 rates rate NNS cord-014516-r59usk02 89 22 1 1 CD cord-014516-r59usk02 89 23 - - SYM cord-014516-r59usk02 89 24 3 3 CD cord-014516-r59usk02 89 25 years year NNS cord-014516-r59usk02 89 26 after after IN cord-014516-r59usk02 89 27 diagnosis diagnosis NN cord-014516-r59usk02 89 28 . . . cord-014516-r59usk02 90 1 Food food NN cord-014516-r59usk02 90 2 - - HYPH cord-014516-r59usk02 90 3 responsive responsive JJ cord-014516-r59usk02 90 4 disease disease NN cord-014516-r59usk02 90 5 ( ( -LRB- cord-014516-r59usk02 90 6 FRD FRD NNP cord-014516-r59usk02 90 7 ) ) -RRB- cord-014516-r59usk02 90 8 was be VBD cord-014516-r59usk02 90 9 defined define VBN cord-014516-r59usk02 90 10 as as IN cord-014516-r59usk02 90 11 dogs dog NNS cord-014516-r59usk02 90 12 that that WDT cord-014516-r59usk02 90 13 responded respond VBD cord-014516-r59usk02 90 14 to to IN cord-014516-r59usk02 90 15 elimination elimination NN cord-014516-r59usk02 90 16 diet diet NN cord-014516-r59usk02 90 17 alone alone RB cord-014516-r59usk02 90 18 within within IN cord-014516-r59usk02 90 19 2 2 CD cord-014516-r59usk02 90 20 weeks week NNS cord-014516-r59usk02 90 21 after after IN cord-014516-r59usk02 90 22 initiating initiate VBG cord-014516-r59usk02 90 23 therapy therapy NN cord-014516-r59usk02 90 24 , , , cord-014516-r59usk02 90 25 whereas whereas IN cord-014516-r59usk02 90 26 antibiotic antibiotic JJ cord-014516-r59usk02 90 27 - - HYPH cord-014516-r59usk02 90 28 responsive responsive JJ cord-014516-r59usk02 90 29 disease disease NN cord-014516-r59usk02 90 30 ( ( -LRB- cord-014516-r59usk02 90 31 ARD ARD NNP cord-014516-r59usk02 90 32 ) ) -RRB- cord-014516-r59usk02 90 33 dogs dog NNS cord-014516-r59usk02 90 34 had have VBD cord-014516-r59usk02 90 35 an an DT cord-014516-r59usk02 90 36 unsuccessful unsuccessful JJ cord-014516-r59usk02 90 37 dietary dietary JJ cord-014516-r59usk02 90 38 trial trial NN cord-014516-r59usk02 90 39 before before RB cord-014516-r59usk02 90 40 and and CC cord-014516-r59usk02 90 41 responded respond VBD cord-014516-r59usk02 90 42 to to IN cord-014516-r59usk02 90 43 metronidazole metronidazole NN cord-014516-r59usk02 90 44 within within IN cord-014516-r59usk02 90 45 2 2 CD cord-014516-r59usk02 90 46 weeks week NNS cord-014516-r59usk02 90 47 after after IN cord-014516-r59usk02 90 48 initiation initiation NN cord-014516-r59usk02 90 49 of of IN cord-014516-r59usk02 90 50 therapy therapy NN cord-014516-r59usk02 90 51 , , , cord-014516-r59usk02 90 52 and and CC cord-014516-r59usk02 90 53 steroidresponsive steroidresponsive JJ cord-014516-r59usk02 90 54 disease disease NN cord-014516-r59usk02 90 55 ( ( -LRB- cord-014516-r59usk02 90 56 SRD)dogs srd)dogs PRP cord-014516-r59usk02 90 57 had have VBD cord-014516-r59usk02 90 58 an an DT cord-014516-r59usk02 90 59 unsuccessful unsuccessful JJ cord-014516-r59usk02 90 60 dietary dietary JJ cord-014516-r59usk02 90 61 and and CC cord-014516-r59usk02 90 62 antimicrobial antimicrobial JJ cord-014516-r59usk02 90 63 trial trial NN cord-014516-r59usk02 90 64 before before RB cord-014516-r59usk02 90 65 , , , cord-014516-r59usk02 90 66 and and CC cord-014516-r59usk02 90 67 required require VBD cord-014516-r59usk02 90 68 immunosuppressive immunosuppressive JJ cord-014516-r59usk02 90 69 therapy therapy NN cord-014516-r59usk02 90 70 to to TO cord-014516-r59usk02 90 71 control control VB cord-014516-r59usk02 90 72 their -PRON- PRP$ cord-014516-r59usk02 90 73 clinical clinical JJ cord-014516-r59usk02 90 74 signs sign NNS cord-014516-r59usk02 90 75 . . . cord-014516-r59usk02 91 1 CCECAI CCECAI NNP cord-014516-r59usk02 91 2 was be VBD cord-014516-r59usk02 91 3 extracted extract VBN cord-014516-r59usk02 91 4 from from IN cord-014516-r59usk02 91 5 the the DT cord-014516-r59usk02 91 6 medical medical JJ cord-014516-r59usk02 91 7 record record NN cord-014516-r59usk02 91 8 database database NN cord-014516-r59usk02 91 9 at at IN cord-014516-r59usk02 91 10 1 1 CD cord-014516-r59usk02 91 11 - - SYM cord-014516-r59usk02 91 12 3 3 CD cord-014516-r59usk02 91 13 years year NNS cord-014516-r59usk02 91 14 after after IN cord-014516-r59usk02 91 15 diagnosis diagnosis NN cord-014516-r59usk02 91 16 . . . cord-014516-r59usk02 92 1 Relapse relapse NN cord-014516-r59usk02 92 2 rate rate NN cord-014516-r59usk02 92 3 was be VBD cord-014516-r59usk02 92 4 obtained obtain VBN cord-014516-r59usk02 92 5 by by IN cord-014516-r59usk02 92 6 requesting request VBG cord-014516-r59usk02 92 7 the the DT cord-014516-r59usk02 92 8 medical medical JJ cord-014516-r59usk02 92 9 records record NNS cord-014516-r59usk02 92 10 of of IN cord-014516-r59usk02 92 11 the the DT cord-014516-r59usk02 92 12 referring refer VBG cord-014516-r59usk02 92 13 veterinarians veterinarian NNS cord-014516-r59usk02 92 14 and and CC cord-014516-r59usk02 92 15 defined define VBN cord-014516-r59usk02 92 16 as as IN cord-014516-r59usk02 92 17 number number NN cord-014516-r59usk02 92 18 of of IN cord-014516-r59usk02 92 19 return return NN cord-014516-r59usk02 92 20 visits visit NNS cord-014516-r59usk02 92 21 to to IN cord-014516-r59usk02 92 22 the the DT cord-014516-r59usk02 92 23 referring refer VBG cord-014516-r59usk02 92 24 practice practice NN cord-014516-r59usk02 92 25 after after IN cord-014516-r59usk02 92 26 diagnosis diagnosis NN cord-014516-r59usk02 92 27 . . . cord-014516-r59usk02 93 1 Compliance compliance NN cord-014516-r59usk02 93 2 data datum NNS cord-014516-r59usk02 93 3 was be VBD cord-014516-r59usk02 93 4 obtained obtain VBN cord-014516-r59usk02 93 5 by by IN cord-014516-r59usk02 93 6 telephone telephone NN cord-014516-r59usk02 93 7 questionnaire questionnaire NN cord-014516-r59usk02 93 8 to to IN cord-014516-r59usk02 93 9 the the DT cord-014516-r59usk02 93 10 owners owner NNS cord-014516-r59usk02 93 11 . . . cord-014516-r59usk02 94 1 The the DT cord-014516-r59usk02 94 2 FRD FRD NNP cord-014516-r59usk02 94 3 group group NN cord-014516-r59usk02 94 4 consisted consist VBD cord-014516-r59usk02 94 5 of of IN cord-014516-r59usk02 94 6 21/29 21/29 CD cord-014516-r59usk02 94 7 dogs dog NNS cord-014516-r59usk02 94 8 ( ( -LRB- cord-014516-r59usk02 94 9 72 72 CD cord-014516-r59usk02 94 10 % % NN cord-014516-r59usk02 94 11 ) ) -RRB- cord-014516-r59usk02 94 12 , , , cord-014516-r59usk02 94 13 whereas whereas IN cord-014516-r59usk02 94 14 the the DT cord-014516-r59usk02 94 15 ARD ARD NNP cord-014516-r59usk02 94 16 and and CC cord-014516-r59usk02 94 17 SRD SRD NNP cord-014516-r59usk02 94 18 groups group NNS cord-014516-r59usk02 94 19 consisted consist VBD cord-014516-r59usk02 94 20 of of IN cord-014516-r59usk02 94 21 4 4 CD cord-014516-r59usk02 94 22 ( ( -LRB- cord-014516-r59usk02 94 23 10 10 CD cord-014516-r59usk02 94 24 % % NN cord-014516-r59usk02 94 25 ) ) -RRB- cord-014516-r59usk02 94 26 and and CC cord-014516-r59usk02 94 27 5 5 CD cord-014516-r59usk02 94 28 dogs dog NNS cord-014516-r59usk02 94 29 ( ( -LRB- cord-014516-r59usk02 94 30 17 17 CD cord-014516-r59usk02 94 31 % % NN cord-014516-r59usk02 94 32 ) ) -RRB- cord-014516-r59usk02 94 33 , , , cord-014516-r59usk02 94 34 respectively respectively RB cord-014516-r59usk02 94 35 . . . cord-014516-r59usk02 95 1 There there EX cord-014516-r59usk02 95 2 was be VBD cord-014516-r59usk02 95 3 a a DT cord-014516-r59usk02 95 4 significant significant JJ cord-014516-r59usk02 95 5 difference difference NN cord-014516-r59usk02 95 6 in in IN cord-014516-r59usk02 95 7 CCECAI CCECAI NNP cord-014516-r59usk02 95 8 at at IN cord-014516-r59usk02 95 9 follow follow NN cord-014516-r59usk02 95 10 - - HYPH cord-014516-r59usk02 95 11 up up NN cord-014516-r59usk02 95 12 between between IN cord-014516-r59usk02 95 13 FRD FRD NNP cord-014516-r59usk02 95 14 and and CC cord-014516-r59usk02 95 15 ARD ARD NNP cord-014516-r59usk02 95 16 , , , cord-014516-r59usk02 95 17 and and CC cord-014516-r59usk02 95 18 FRD FRD NNP cord-014516-r59usk02 95 19 and and CC cord-014516-r59usk02 95 20 SRD SRD NNP cord-014516-r59usk02 95 21 ( ( -LRB- cord-014516-r59usk02 95 22 median median JJ cord-014516-r59usk02 95 23 CCECAI CCECAI NNP cord-014516-r59usk02 95 24 1.8 1.8 CD cord-014516-r59usk02 95 25 ( ( -LRB- cord-014516-r59usk02 95 26 range range NN cord-014516-r59usk02 95 27 0 0 CD cord-014516-r59usk02 95 28 - - SYM cord-014516-r59usk02 95 29 5 5 CD cord-014516-r59usk02 95 30 ) ) -RRB- cord-014516-r59usk02 95 31 for for IN cord-014516-r59usk02 95 32 FRD FRD NNP cord-014516-r59usk02 95 33 , , , cord-014516-r59usk02 95 34 5 5 CD cord-014516-r59usk02 95 35 ( ( -LRB- cord-014516-r59usk02 95 36 range range VB cord-014516-r59usk02 95 37 0 0 CD cord-014516-r59usk02 95 38 - - SYM cord-014516-r59usk02 95 39 8 8 CD cord-014516-r59usk02 95 40 ) ) -RRB- cord-014516-r59usk02 95 41 for for IN cord-014516-r59usk02 95 42 ARD ARD NNP cord-014516-r59usk02 95 43 , , , cord-014516-r59usk02 95 44 and and CC cord-014516-r59usk02 95 45 4.5 4.5 CD cord-014516-r59usk02 95 46 ( ( -LRB- cord-014516-r59usk02 95 47 range range NN cord-014516-r59usk02 95 48 0 0 CD cord-014516-r59usk02 95 49 - - SYM cord-014516-r59usk02 95 50 8 8 CD cord-014516-r59usk02 95 51 ) ) -RRB- cord-014516-r59usk02 95 52 for for IN cord-014516-r59usk02 95 53 SRD SRD NNP cord-014516-r59usk02 95 54 , , , cord-014516-r59usk02 95 55 p p NN cord-014516-r59usk02 95 56 = = SYM cord-014516-r59usk02 95 57 0.01 0.01 CD cord-014516-r59usk02 95 58 ) ) -RRB- cord-014516-r59usk02 95 59 . . . cord-014516-r59usk02 96 1 For for IN cord-014516-r59usk02 96 2 the the DT cord-014516-r59usk02 96 3 FRD FRD NNP cord-014516-r59usk02 96 4 dogs dog NNS cord-014516-r59usk02 96 5 , , , cord-014516-r59usk02 96 6 43 43 CD cord-014516-r59usk02 96 7 % % NN cord-014516-r59usk02 96 8 of of IN cord-014516-r59usk02 96 9 owners owner NNS cord-014516-r59usk02 96 10 stated state VBD cord-014516-r59usk02 96 11 that that IN cord-014516-r59usk02 96 12 they -PRON- PRP cord-014516-r59usk02 96 13 deviated deviate VBD cord-014516-r59usk02 96 14 from from IN cord-014516-r59usk02 96 15 the the DT cord-014516-r59usk02 96 16 prescription prescription NN cord-014516-r59usk02 96 17 diet diet NN cord-014516-r59usk02 96 18 on on IN cord-014516-r59usk02 96 19 a a DT cord-014516-r59usk02 96 20 daily daily JJ cord-014516-r59usk02 96 21 basis basis NN cord-014516-r59usk02 96 22 , , , cord-014516-r59usk02 96 23 24 24 CD cord-014516-r59usk02 96 24 % % NN cord-014516-r59usk02 96 25 once once RB cord-014516-r59usk02 96 26 a a DT cord-014516-r59usk02 96 27 week week NN cord-014516-r59usk02 96 28 , , , cord-014516-r59usk02 96 29 and and CC cord-014516-r59usk02 96 30 5 5 CD cord-014516-r59usk02 96 31 % % NN cord-014516-r59usk02 96 32 once once RB cord-014516-r59usk02 96 33 a a DT cord-014516-r59usk02 96 34 month month NN cord-014516-r59usk02 96 35 , , , cord-014516-r59usk02 96 36 with with IN cord-014516-r59usk02 96 37 a a DT cord-014516-r59usk02 96 38 median median JJ cord-014516-r59usk02 96 39 CCECAI CCECAI NNP cord-014516-r59usk02 96 40 at at IN cord-014516-r59usk02 96 41 the the DT cord-014516-r59usk02 96 42 time time NN cord-014516-r59usk02 96 43 of of IN cord-014516-r59usk02 96 44 deviation deviation NN cord-014516-r59usk02 96 45 from from IN cord-014516-r59usk02 96 46 the the DT cord-014516-r59usk02 96 47 diet diet NN cord-014516-r59usk02 96 48 of of IN cord-014516-r59usk02 96 49 4.8 4.8 CD cord-014516-r59usk02 96 50 ( ( -LRB- cord-014516-r59usk02 96 51 range range NNP cord-014516-r59usk02 96 52 2 2 CD cord-014516-r59usk02 96 53 - - SYM cord-014516-r59usk02 96 54 8 8 CD cord-014516-r59usk02 96 55 ) ) -RRB- cord-014516-r59usk02 96 56 . . . cord-014516-r59usk02 97 1 Relapse relapse NN cord-014516-r59usk02 97 2 rate rate NN cord-014516-r59usk02 97 3 was be VBD cord-014516-r59usk02 97 4 highest high JJS cord-014516-r59usk02 97 5 for for IN cord-014516-r59usk02 97 6 the the DT cord-014516-r59usk02 97 7 ARD ARD NNP cord-014516-r59usk02 97 8 group group NN cord-014516-r59usk02 97 9 , , , cord-014516-r59usk02 97 10 when when WRB cord-014516-r59usk02 97 11 compared compare VBN cord-014516-r59usk02 97 12 to to IN cord-014516-r59usk02 97 13 FRD FRD NNP cord-014516-r59usk02 97 14 and and CC cord-014516-r59usk02 97 15 SRD SRD NNP cord-014516-r59usk02 97 16 ( ( -LRB- cord-014516-r59usk02 97 17 10 10 CD cord-014516-r59usk02 97 18 for for IN cord-014516-r59usk02 97 19 ARD ARD NNP cord-014516-r59usk02 97 20 , , , cord-014516-r59usk02 97 21 1.7 1.7 CD cord-014516-r59usk02 97 22 for for IN cord-014516-r59usk02 97 23 FRD FRD NNP cord-014516-r59usk02 97 24 , , , cord-014516-r59usk02 97 25 and and CC cord-014516-r59usk02 97 26 4.7 4.7 CD cord-014516-r59usk02 97 27 for for IN cord-014516-r59usk02 97 28 SRD SRD NNP cord-014516-r59usk02 97 29 , , , cord-014516-r59usk02 97 30 p p NN cord-014516-r59usk02 97 31 = = SYM cord-014516-r59usk02 97 32 0.004 0.004 CD cord-014516-r59usk02 97 33 ) ) -RRB- cord-014516-r59usk02 97 34 . . . cord-014516-r59usk02 98 1 In in IN cord-014516-r59usk02 98 2 the the DT cord-014516-r59usk02 98 3 FRD FRD NNP cord-014516-r59usk02 98 4 group group NN cord-014516-r59usk02 98 5 , , , cord-014516-r59usk02 98 6 17/21 17/21 CD cord-014516-r59usk02 98 7 dogs dog NNS cord-014516-r59usk02 98 8 had have VBD cord-014516-r59usk02 98 9 been be VBN cord-014516-r59usk02 98 10 kept keep VBN cord-014516-r59usk02 98 11 on on IN cord-014516-r59usk02 98 12 the the DT cord-014516-r59usk02 98 13 prescribed prescribed JJ cord-014516-r59usk02 98 14 diets diet NNS cord-014516-r59usk02 98 15 , , , cord-014516-r59usk02 98 16 and and CC cord-014516-r59usk02 98 17 4 4 CD cord-014516-r59usk02 98 18 dogs dog NNS cord-014516-r59usk02 98 19 had have VBD cord-014516-r59usk02 98 20 been be VBN cord-014516-r59usk02 98 21 changed change VBN cord-014516-r59usk02 98 22 to to IN cord-014516-r59usk02 98 23 supermarket supermarket NN cord-014516-r59usk02 98 24 brands brand NNS cord-014516-r59usk02 98 25 . . . cord-014516-r59usk02 99 1 All all DT cord-014516-r59usk02 99 2 of of IN cord-014516-r59usk02 99 3 the the DT cord-014516-r59usk02 99 4 ARD ARD NNP cord-014516-r59usk02 99 5 dogs dog NNS cord-014516-r59usk02 99 6 had have VBD cord-014516-r59usk02 99 7 been be VBN cord-014516-r59usk02 99 8 given give VBN cord-014516-r59usk02 99 9 immunosuppressive immunosuppressive JJ cord-014516-r59usk02 99 10 treatment treatment NN cord-014516-r59usk02 99 11 in in IN cord-014516-r59usk02 99 12 addition addition NN cord-014516-r59usk02 99 13 to to IN cord-014516-r59usk02 99 14 antibiotics antibiotic NNS cord-014516-r59usk02 99 15 at at IN cord-014516-r59usk02 99 16 the the DT cord-014516-r59usk02 99 17 time time NN cord-014516-r59usk02 99 18 of of IN cord-014516-r59usk02 99 19 follow follow NN cord-014516-r59usk02 99 20 - - HYPH cord-014516-r59usk02 99 21 up up NN cord-014516-r59usk02 99 22 , , , cord-014516-r59usk02 99 23 while while IN cord-014516-r59usk02 99 24 4/5 4/5 CD cord-014516-r59usk02 99 25 SRD SRD NNP cord-014516-r59usk02 99 26 dogs dog NNS cord-014516-r59usk02 99 27 were be VBD cord-014516-r59usk02 99 28 still still RB cord-014516-r59usk02 99 29 on on IN cord-014516-r59usk02 99 30 immunosuppressive immunosuppressive JJ cord-014516-r59usk02 99 31 treatments treatment NNS cord-014516-r59usk02 99 32 , , , cord-014516-r59usk02 99 33 with with IN cord-014516-r59usk02 99 34 one one CD cord-014516-r59usk02 99 35 dog dog NN cord-014516-r59usk02 99 36 being be VBG cord-014516-r59usk02 99 37 in in IN cord-014516-r59usk02 99 38 remission remission NN cord-014516-r59usk02 99 39 with with IN cord-014516-r59usk02 99 40 dietary dietary JJ cord-014516-r59usk02 99 41 treatment treatment NN cord-014516-r59usk02 99 42 alone alone RB cord-014516-r59usk02 99 43 . . . cord-014516-r59usk02 100 1 In in IN cord-014516-r59usk02 100 2 conclusion conclusion NN cord-014516-r59usk02 100 3 , , , cord-014516-r59usk02 100 4 this this DT cord-014516-r59usk02 100 5 pilot pilot NN cord-014516-r59usk02 100 6 study study NN cord-014516-r59usk02 100 7 indicates indicate VBZ cord-014516-r59usk02 100 8 that that IN cord-014516-r59usk02 100 9 compliance compliance NN cord-014516-r59usk02 100 10 rate rate NN cord-014516-r59usk02 100 11 for for IN cord-014516-r59usk02 100 12 FRD FRD NNP cord-014516-r59usk02 100 13 dogs dog NNS cord-014516-r59usk02 100 14 is be VBZ cord-014516-r59usk02 100 15 the the DT cord-014516-r59usk02 100 16 lowest low JJS cord-014516-r59usk02 100 17 , , , cord-014516-r59usk02 100 18 with with IN cord-014516-r59usk02 100 19 owners owner NNS cord-014516-r59usk02 100 20 willing willing JJ cord-014516-r59usk02 100 21 to to TO cord-014516-r59usk02 100 22 tolerate tolerate VB cord-014516-r59usk02 100 23 the the DT cord-014516-r59usk02 100 24 highest high JJS cord-014516-r59usk02 100 25 severity severity NN cord-014516-r59usk02 100 26 of of IN cord-014516-r59usk02 100 27 clinical clinical JJ cord-014516-r59usk02 100 28 signs sign NNS cord-014516-r59usk02 100 29 related relate VBN cord-014516-r59usk02 100 30 to to IN cord-014516-r59usk02 100 31 deviation deviation NN cord-014516-r59usk02 100 32 from from IN cord-014516-r59usk02 100 33 the the DT cord-014516-r59usk02 100 34 prescription prescription NN cord-014516-r59usk02 100 35 diet diet NN cord-014516-r59usk02 100 36 . . . cord-014516-r59usk02 101 1 ARD ARD NNP cord-014516-r59usk02 101 2 dogs dog NNS cord-014516-r59usk02 101 3 had have VBD cord-014516-r59usk02 101 4 the the DT cord-014516-r59usk02 101 5 highest high JJS cord-014516-r59usk02 101 6 relapse relapse NN cord-014516-r59usk02 101 7 rate rate NN cord-014516-r59usk02 101 8 in in IN cord-014516-r59usk02 101 9 this this DT cord-014516-r59usk02 101 10 cohort cohort NN cord-014516-r59usk02 101 11 , , , cord-014516-r59usk02 101 12 indicating indicate VBG cord-014516-r59usk02 101 13 poor poor JJ cord-014516-r59usk02 101 14 response response NN cord-014516-r59usk02 101 15 to to IN cord-014516-r59usk02 101 16 treatment treatment NN cord-014516-r59usk02 101 17 in in IN cord-014516-r59usk02 101 18 the the DT cord-014516-r59usk02 101 19 long long JJ cord-014516-r59usk02 101 20 - - HYPH cord-014516-r59usk02 101 21 term term NN cord-014516-r59usk02 101 22 . . . cord-014516-r59usk02 102 1 Conflicts conflict NNS cord-014516-r59usk02 102 2 of of IN cord-014516-r59usk02 102 3 interest interest NN cord-014516-r59usk02 102 4 : : : cord-014516-r59usk02 102 5 Dr Dr NNP cord-014516-r59usk02 102 6 Allenspach Allenspach NNP cord-014516-r59usk02 102 7 has have VBZ cord-014516-r59usk02 102 8 received receive VBN cord-014516-r59usk02 102 9 research research NN cord-014516-r59usk02 102 10 funding funding NN cord-014516-r59usk02 102 11 from from IN cord-014516-r59usk02 102 12 BBSRC BBSRC NNP cord-014516-r59usk02 102 13 , , , cord-014516-r59usk02 102 14 American American NNP cord-014516-r59usk02 102 15 Kennel Kennel NNP cord-014516-r59usk02 102 16 Club Club NNP cord-014516-r59usk02 102 17 , , , cord-014516-r59usk02 102 18 Comparative Comparative NNP cord-014516-r59usk02 102 19 Gastroenterology Gastroenterology NNP cord-014516-r59usk02 102 20 Society Society NNP cord-014516-r59usk02 102 21 , , , cord-014516-r59usk02 102 22 Probiotics Probiotics NNP cord-014516-r59usk02 102 23 Ltd Ltd NNP cord-014516-r59usk02 102 24 UK UK NNP cord-014516-r59usk02 102 25 , , , cord-014516-r59usk02 102 26 Laboklin Laboklin NNP cord-014516-r59usk02 102 27 GmBH GmBH NNP cord-014516-r59usk02 102 28 Germany Germany NNP cord-014516-r59usk02 102 29 , , , cord-014516-r59usk02 102 30 and and CC cord-014516-r59usk02 102 31 Bioiberica Bioiberica NNP cord-014516-r59usk02 102 32 Sp Sp NNP cord-014516-r59usk02 102 33 . . . cord-014516-r59usk02 103 1 she -PRON- PRP cord-014516-r59usk02 103 2 has have VBZ cord-014516-r59usk02 103 3 also also RB cord-014516-r59usk02 103 4 undertaken undertake VBN cord-014516-r59usk02 103 5 paid pay VBN cord-014516-r59usk02 103 6 consultancy consultancy NN cord-014516-r59usk02 103 7 work work NN cord-014516-r59usk02 103 8 for for IN cord-014516-r59usk02 103 9 Bioiberica Bioiberica NNP cord-014516-r59usk02 103 10 Spain Spain NNP cord-014516-r59usk02 103 11 and and CC cord-014516-r59usk02 103 12 Hoffmann Hoffmann NNP cord-014516-r59usk02 103 13 - - HYPH cord-014516-r59usk02 103 14 Laroche Laroche NNP cord-014516-r59usk02 103 15 , , , cord-014516-r59usk02 103 16 Switzerland Switzerland NNP cord-014516-r59usk02 103 17 . . . cord-014516-r59usk02 104 1 Despite despite IN cord-014516-r59usk02 104 2 the the DT cord-014516-r59usk02 104 3 high high JJ cord-014516-r59usk02 104 4 prevalence prevalence NN cord-014516-r59usk02 104 5 of of IN cord-014516-r59usk02 104 6 canine canine JJ cord-014516-r59usk02 104 7 pancreatitis pancreatitis NN cord-014516-r59usk02 104 8 in in IN cord-014516-r59usk02 104 9 postmortem postmortem JJ cord-014516-r59usk02 104 10 studies study NNS cord-014516-r59usk02 104 11 and and CC cord-014516-r59usk02 104 12 the the DT cord-014516-r59usk02 104 13 introduction introduction NN cord-014516-r59usk02 104 14 of of IN cord-014516-r59usk02 104 15 new new JJ cord-014516-r59usk02 104 16 diagnostic diagnostic JJ cord-014516-r59usk02 104 17 tests test NNS cord-014516-r59usk02 104 18 , , , cord-014516-r59usk02 104 19 it -PRON- PRP cord-014516-r59usk02 104 20 is be VBZ cord-014516-r59usk02 104 21 believed believe VBN cord-014516-r59usk02 104 22 that that IN cord-014516-r59usk02 104 23 the the DT cord-014516-r59usk02 104 24 disease disease NN cord-014516-r59usk02 104 25 , , , cord-014516-r59usk02 104 26 particularly particularly RB cord-014516-r59usk02 104 27 in in IN cord-014516-r59usk02 104 28 its -PRON- PRP$ cord-014516-r59usk02 104 29 chronic chronic JJ cord-014516-r59usk02 104 30 form form NN cord-014516-r59usk02 104 31 , , , cord-014516-r59usk02 104 32 remains remain VBZ cord-014516-r59usk02 104 33 under under IN cord-014516-r59usk02 104 34 recognised recognise VBN cord-014516-r59usk02 104 35 due due IN cord-014516-r59usk02 104 36 to to IN cord-014516-r59usk02 104 37 the the DT cord-014516-r59usk02 104 38 non non JJ cord-014516-r59usk02 104 39 - - JJ cord-014516-r59usk02 104 40 specific specific JJ cord-014516-r59usk02 104 41 nature nature NN cord-014516-r59usk02 104 42 of of IN cord-014516-r59usk02 104 43 presenting present VBG cord-014516-r59usk02 104 44 signs sign NNS cord-014516-r59usk02 104 45 . . . cord-014516-r59usk02 105 1 Histology histology NN cord-014516-r59usk02 105 2 is be VBZ cord-014516-r59usk02 105 3 considered consider VBN cord-014516-r59usk02 105 4 to to TO cord-014516-r59usk02 105 5 be be VB cord-014516-r59usk02 105 6 the the DT cord-014516-r59usk02 105 7 gold gold NN cord-014516-r59usk02 105 8 standard standard NN cord-014516-r59usk02 105 9 for for IN cord-014516-r59usk02 105 10 diagnosis diagnosis NN cord-014516-r59usk02 105 11 of of IN cord-014516-r59usk02 105 12 canine canine JJ cord-014516-r59usk02 105 13 pancreatitis pancreatitis NN cord-014516-r59usk02 105 14 , , , cord-014516-r59usk02 105 15 however however RB cord-014516-r59usk02 105 16 , , , cord-014516-r59usk02 105 17 most most JJS cord-014516-r59usk02 105 18 clinicians clinician NNS cord-014516-r59usk02 105 19 are be VBP cord-014516-r59usk02 105 20 reluctant reluctant JJ cord-014516-r59usk02 105 21 to to TO cord-014516-r59usk02 105 22 take take VB cord-014516-r59usk02 105 23 pancreatic pancreatic JJ cord-014516-r59usk02 105 24 biopsies biopsy NNS cord-014516-r59usk02 105 25 due due JJ cord-014516-r59usk02 105 26 to to IN cord-014516-r59usk02 105 27 significant significant JJ cord-014516-r59usk02 105 28 risks risk NNS cord-014516-r59usk02 105 29 to to IN cord-014516-r59usk02 105 30 the the DT cord-014516-r59usk02 105 31 patient patient NN cord-014516-r59usk02 105 32 . . . cord-014516-r59usk02 106 1 Numerous numerous JJ cord-014516-r59usk02 106 2 serum serum NN cord-014516-r59usk02 106 3 markers marker NNS cord-014516-r59usk02 106 4 have have VBP cord-014516-r59usk02 106 5 been be VBN cord-014516-r59usk02 106 6 reported report VBN cord-014516-r59usk02 106 7 to to TO cord-014516-r59usk02 106 8 be be VB cord-014516-r59usk02 106 9 elevated elevate VBN cord-014516-r59usk02 106 10 in in IN cord-014516-r59usk02 106 11 canine canine JJ cord-014516-r59usk02 106 12 pancreatitis pancreatitis NN cord-014516-r59usk02 106 13 , , , cord-014516-r59usk02 106 14 although although IN cord-014516-r59usk02 106 15 most most JJS cord-014516-r59usk02 106 16 lack lack VBP cord-014516-r59usk02 106 17 sensitivity sensitivity NN cord-014516-r59usk02 106 18 or or CC cord-014516-r59usk02 106 19 specificity specificity NN cord-014516-r59usk02 106 20 . . . cord-014516-r59usk02 107 1 Consequently consequently RB cord-014516-r59usk02 107 2 , , , cord-014516-r59usk02 107 3 confirmed confirm VBD cord-014516-r59usk02 107 4 diagnosis diagnosis NN cord-014516-r59usk02 107 5 requires require VBZ cord-014516-r59usk02 107 6 results result NNS cord-014516-r59usk02 107 7 from from IN cord-014516-r59usk02 107 8 a a DT cord-014516-r59usk02 107 9 range range NN cord-014516-r59usk02 107 10 of of IN cord-014516-r59usk02 107 11 tests test NNS cord-014516-r59usk02 107 12 including include VBG cord-014516-r59usk02 107 13 imaging image VBG cord-014516-r59usk02 107 14 , , , cord-014516-r59usk02 107 15 serum serum NN cord-014516-r59usk02 107 16 biochemistry biochemistry NN cord-014516-r59usk02 107 17 and and CC cord-014516-r59usk02 107 18 physical physical JJ cord-014516-r59usk02 107 19 examination examination NN cord-014516-r59usk02 107 20 . . . cord-014516-r59usk02 108 1 We -PRON- PRP cord-014516-r59usk02 108 2 and and CC cord-014516-r59usk02 108 3 others other NNS cord-014516-r59usk02 108 4 have have VBP cord-014516-r59usk02 108 5 previously previously RB cord-014516-r59usk02 108 6 shown show VBN cord-014516-r59usk02 108 7 in in IN cord-014516-r59usk02 108 8 other other JJ cord-014516-r59usk02 108 9 diseases disease NNS cord-014516-r59usk02 108 10 that that WDT cord-014516-r59usk02 108 11 performance performance NN cord-014516-r59usk02 108 12 of of IN cord-014516-r59usk02 108 13 individual individual JJ cord-014516-r59usk02 108 14 low low JJ cord-014516-r59usk02 108 15 specificity specificity NN cord-014516-r59usk02 108 16 markers marker NNS cord-014516-r59usk02 108 17 can can MD cord-014516-r59usk02 108 18 be be VB cord-014516-r59usk02 108 19 dramatically dramatically RB cord-014516-r59usk02 108 20 improved improve VBN cord-014516-r59usk02 108 21 by by IN cord-014516-r59usk02 108 22 combining combine VBG cord-014516-r59usk02 108 23 data datum NNS cord-014516-r59usk02 108 24 from from IN cord-014516-r59usk02 108 25 multiple multiple JJ cord-014516-r59usk02 108 26 markers marker NNS cord-014516-r59usk02 108 27 with with IN cord-014516-r59usk02 108 28 clinical clinical JJ cord-014516-r59usk02 108 29 information information NN cord-014516-r59usk02 108 30 using use VBG cord-014516-r59usk02 108 31 analytical analytical JJ cord-014516-r59usk02 108 32 algorithms algorithm NNS cord-014516-r59usk02 108 33 . . . cord-014516-r59usk02 109 1 We -PRON- PRP cord-014516-r59usk02 109 2 therefore therefore RB cord-014516-r59usk02 109 3 applied apply VBD cord-014516-r59usk02 109 4 this this DT cord-014516-r59usk02 109 5 approach approach NN cord-014516-r59usk02 109 6 to to IN cord-014516-r59usk02 109 7 the the DT cord-014516-r59usk02 109 8 detection detection NN cord-014516-r59usk02 109 9 of of IN cord-014516-r59usk02 109 10 pancreatitis pancreatitis NN cord-014516-r59usk02 109 11 in in IN cord-014516-r59usk02 109 12 dogs dog NNS cord-014516-r59usk02 109 13 . . . cord-014516-r59usk02 110 1 The the DT cord-014516-r59usk02 110 2 activity activity NN cord-014516-r59usk02 110 3 of of IN cord-014516-r59usk02 110 4 two two CD cord-014516-r59usk02 110 5 non non JJ cord-014516-r59usk02 110 6 - - JJ cord-014516-r59usk02 110 7 specific specific JJ cord-014516-r59usk02 110 8 biomarkers biomarker NNS cord-014516-r59usk02 110 9 , , , cord-014516-r59usk02 110 10 amylase amylase NN cord-014516-r59usk02 110 11 and and CC cord-014516-r59usk02 110 12 lipase lipase NN cord-014516-r59usk02 110 13 , , , cord-014516-r59usk02 110 14 was be VBD cord-014516-r59usk02 110 15 determined determine VBN cord-014516-r59usk02 110 16 in in IN cord-014516-r59usk02 110 17 132 132 CD cord-014516-r59usk02 110 18 serum serum NN cord-014516-r59usk02 110 19 samples sample NNS cord-014516-r59usk02 110 20 from from IN cord-014516-r59usk02 110 21 dogs dog NNS cord-014516-r59usk02 110 22 suspected suspect VBN cord-014516-r59usk02 110 23 of of IN cord-014516-r59usk02 110 24 having have VBG cord-014516-r59usk02 110 25 pancreatitis pancreatitis NN cord-014516-r59usk02 110 26 by by IN cord-014516-r59usk02 110 27 their -PRON- PRP$ cord-014516-r59usk02 110 28 veterinarian veterinarian NN cord-014516-r59usk02 110 29 . . . cord-014516-r59usk02 111 1 Of of IN cord-014516-r59usk02 111 2 these these DT cord-014516-r59usk02 111 3 samples sample NNS cord-014516-r59usk02 111 4 42 42 CD cord-014516-r59usk02 111 5 were be VBD cord-014516-r59usk02 111 6 positive positive JJ cord-014516-r59usk02 111 7 by by IN cord-014516-r59usk02 111 8 virtue virtue NN cord-014516-r59usk02 111 9 of of IN cord-014516-r59usk02 111 10 their -PRON- PRP$ cord-014516-r59usk02 111 11 pancreatic pancreatic JJ cord-014516-r59usk02 111 12 lipase lipase NN cord-014516-r59usk02 111 13 ( ( -LRB- cord-014516-r59usk02 111 14 cPLi cPLi NNP cord-014516-r59usk02 111 15 ) ) -RRB- cord-014516-r59usk02 111 16 results result NNS cord-014516-r59usk02 111 17 ( ( -LRB- cord-014516-r59usk02 111 18 cPLi cpli XX cord-014516-r59usk02 112 1 > > XX cord-014516-r59usk02 113 1 200 200 CD cord-014516-r59usk02 113 2 ug ug NNP cord-014516-r59usk02 113 3 / / SYM cord-014516-r59usk02 113 4 l l NN cord-014516-r59usk02 113 5 ) ) -RRB- cord-014516-r59usk02 113 6 . . . cord-014516-r59usk02 114 1 The the DT cord-014516-r59usk02 114 2 amylase amylase NN cord-014516-r59usk02 114 3 and and CC cord-014516-r59usk02 114 4 lipase lipase NN cord-014516-r59usk02 114 5 data datum NNS cord-014516-r59usk02 114 6 was be VBD cord-014516-r59usk02 114 7 then then RB cord-014516-r59usk02 114 8 used use VBN cord-014516-r59usk02 114 9 to to TO cord-014516-r59usk02 114 10 develop develop VB cord-014516-r59usk02 114 11 a a DT cord-014516-r59usk02 114 12 series series NN cord-014516-r59usk02 114 13 of of IN cord-014516-r59usk02 114 14 algorithms algorithm NNS cord-014516-r59usk02 114 15 using use VBG cord-014516-r59usk02 114 16 mathematical mathematical JJ cord-014516-r59usk02 114 17 data datum NNS cord-014516-r59usk02 114 18 mining mining NN cord-014516-r59usk02 114 19 and and CC cord-014516-r59usk02 114 20 classification classification NN cord-014516-r59usk02 114 21 techniques technique NNS cord-014516-r59usk02 114 22 . . . cord-014516-r59usk02 115 1 Additional additional JJ cord-014516-r59usk02 115 2 algorithms algorithm NNS cord-014516-r59usk02 115 3 were be VBD cord-014516-r59usk02 115 4 developed develop VBN cord-014516-r59usk02 115 5 using use VBG cord-014516-r59usk02 115 6 extra extra JJ cord-014516-r59usk02 115 7 parameters parameter NNS cord-014516-r59usk02 115 8 including include VBG cord-014516-r59usk02 115 9 age age NN cord-014516-r59usk02 115 10 , , , cord-014516-r59usk02 115 11 sex sex NN cord-014516-r59usk02 115 12 , , , cord-014516-r59usk02 115 13 vomiting vomiting NN cord-014516-r59usk02 115 14 , , , cord-014516-r59usk02 115 15 diarrhoea diarrhoea NN cord-014516-r59usk02 115 16 and and CC cord-014516-r59usk02 115 17 abdominal abdominal JJ cord-014516-r59usk02 115 18 pain pain NN cord-014516-r59usk02 115 19 in in IN cord-014516-r59usk02 115 20 addition addition NN cord-014516-r59usk02 115 21 to to IN cord-014516-r59usk02 115 22 the the DT cord-014516-r59usk02 115 23 two two CD cord-014516-r59usk02 115 24 enzyme enzyme NN cord-014516-r59usk02 115 25 levels level NNS cord-014516-r59usk02 115 26 . . . cord-014516-r59usk02 116 1 The the DT cord-014516-r59usk02 116 2 performance performance NN cord-014516-r59usk02 116 3 of of IN cord-014516-r59usk02 116 4 the the DT cord-014516-r59usk02 116 5 algorithms algorithm NNS cord-014516-r59usk02 116 6 was be VBD cord-014516-r59usk02 116 7 assessed assess VBN cord-014516-r59usk02 116 8 using use VBG cord-014516-r59usk02 116 9 27 27 CD cord-014516-r59usk02 116 10 separate separate JJ cord-014516-r59usk02 116 11 blinded blinded JJ cord-014516-r59usk02 116 12 serum serum NN cord-014516-r59usk02 116 13 samples sample NNS cord-014516-r59usk02 116 14 taken take VBN cord-014516-r59usk02 116 15 from from IN cord-014516-r59usk02 116 16 dogs dog NNS cord-014516-r59usk02 116 17 which which WDT cord-014516-r59usk02 116 18 were be VBD cord-014516-r59usk02 116 19 scored score VBN cord-014516-r59usk02 116 20 clinically clinically RB cord-014516-r59usk02 116 21 for for IN cord-014516-r59usk02 116 22 acute acute JJ cord-014516-r59usk02 116 23 pancreatitis pancreatitis NN cord-014516-r59usk02 116 24 according accord VBG cord-014516-r59usk02 116 25 to to IN cord-014516-r59usk02 116 26 the the DT cord-014516-r59usk02 116 27 system system NN cord-014516-r59usk02 116 28 described describe VBN cord-014516-r59usk02 116 29 by by IN cord-014516-r59usk02 116 30 McCord McCord NNP cord-014516-r59usk02 116 31 et et NNP cord-014516-r59usk02 116 32 al al NNP cord-014516-r59usk02 116 33 ( ( -LRB- cord-014516-r59usk02 116 34 J J NNP cord-014516-r59usk02 116 35 Vet Vet NNP cord-014516-r59usk02 116 36 Intern Intern NNP cord-014516-r59usk02 116 37 Med Med NNP cord-014516-r59usk02 116 38 2012 2012 CD cord-014516-r59usk02 116 39 ; ; : cord-014516-r59usk02 116 40 26:888 26:888 CD cord-014516-r59usk02 116 41 - - HYPH cord-014516-r59usk02 116 42 896 896 CD cord-014516-r59usk02 116 43 ) ) -RRB- cord-014516-r59usk02 116 44 . . . cord-014516-r59usk02 117 1 These these DT cord-014516-r59usk02 117 2 cases case NNS cord-014516-r59usk02 117 3 presented present VBN cord-014516-r59usk02 117 4 for for IN cord-014516-r59usk02 117 5 evaluation evaluation NN cord-014516-r59usk02 117 6 with with IN cord-014516-r59usk02 117 7 vomiting vomiting NN cord-014516-r59usk02 117 8 , , , cord-014516-r59usk02 117 9 diarrhoea diarrhoea NN cord-014516-r59usk02 117 10 , , , cord-014516-r59usk02 117 11 inappetance inappetance NN cord-014516-r59usk02 117 12 and and CC cord-014516-r59usk02 117 13 abdominal abdominal JJ cord-014516-r59usk02 117 14 pain pain NN cord-014516-r59usk02 117 15 and and CC cord-014516-r59usk02 117 16 were be VBD cord-014516-r59usk02 117 17 included include VBN cord-014516-r59usk02 117 18 if if IN cord-014516-r59usk02 117 19 a a DT cord-014516-r59usk02 117 20 clinical clinical JJ cord-014516-r59usk02 117 21 history history NN cord-014516-r59usk02 117 22 , , , cord-014516-r59usk02 117 23 results result NNS cord-014516-r59usk02 117 24 of of IN cord-014516-r59usk02 117 25 routine routine JJ cord-014516-r59usk02 117 26 haematology haematology NN cord-014516-r59usk02 117 27 , , , cord-014516-r59usk02 117 28 biochemistry biochemistry NN cord-014516-r59usk02 117 29 , , , cord-014516-r59usk02 117 30 cPLi cpli NN cord-014516-r59usk02 117 31 assay assay NN cord-014516-r59usk02 117 32 and and CC cord-014516-r59usk02 117 33 abdominal abdominal JJ cord-014516-r59usk02 117 34 ultrasound ultrasound NN cord-014516-r59usk02 117 35 were be VBD cord-014516-r59usk02 117 36 available available JJ cord-014516-r59usk02 117 37 . . . cord-014516-r59usk02 118 1 The the DT cord-014516-r59usk02 118 2 results result NNS cord-014516-r59usk02 118 3 of of IN cord-014516-r59usk02 118 4 the the DT cord-014516-r59usk02 118 5 multifactorial multifactorial JJ cord-014516-r59usk02 118 6 analysis analysis NN cord-014516-r59usk02 118 7 and and CC cord-014516-r59usk02 118 8 cPLi cpli NN cord-014516-r59usk02 118 9 assay assay NN cord-014516-r59usk02 118 10 results result NNS cord-014516-r59usk02 118 11 were be VBD cord-014516-r59usk02 118 12 compared compare VBN cord-014516-r59usk02 118 13 to to IN cord-014516-r59usk02 118 14 the the DT cord-014516-r59usk02 118 15 clinical clinical JJ cord-014516-r59usk02 118 16 scores score NNS cord-014516-r59usk02 118 17 . . . cord-014516-r59usk02 119 1 Using use VBG cord-014516-r59usk02 119 2 amylase amylase NN cord-014516-r59usk02 119 3 and and CC cord-014516-r59usk02 119 4 lipase lipase NN cord-014516-r59usk02 119 5 data datum NNS cord-014516-r59usk02 119 6 alone alone RB cord-014516-r59usk02 119 7 , , , cord-014516-r59usk02 119 8 the the DT cord-014516-r59usk02 119 9 algorithm algorithm NN cord-014516-r59usk02 119 10 gave give VBD cord-014516-r59usk02 119 11 a a DT cord-014516-r59usk02 119 12 sensitivity sensitivity NN cord-014516-r59usk02 119 13 of of IN cord-014516-r59usk02 119 14 81.8 81.8 CD cord-014516-r59usk02 119 15 % % NN cord-014516-r59usk02 119 16 and and CC cord-014516-r59usk02 119 17 specificity specificity NN cord-014516-r59usk02 119 18 of of IN cord-014516-r59usk02 119 19 93.3 93.3 CD cord-014516-r59usk02 119 20 % % NN cord-014516-r59usk02 119 21 , , , cord-014516-r59usk02 119 22 compared compare VBN cord-014516-r59usk02 119 23 to to IN cord-014516-r59usk02 119 24 cPLi cpli VB cord-014516-r59usk02 119 25 results result NNS cord-014516-r59usk02 119 26 for for IN cord-014516-r59usk02 119 27 the the DT cord-014516-r59usk02 119 28 same same JJ cord-014516-r59usk02 119 29 samples sample NNS cord-014516-r59usk02 119 30 of of IN cord-014516-r59usk02 119 31 63.6 63.6 CD cord-014516-r59usk02 119 32 % % NN cord-014516-r59usk02 119 33 and and CC cord-014516-r59usk02 119 34 86.7 86.7 CD cord-014516-r59usk02 119 35 % % NN cord-014516-r59usk02 119 36 respectively respectively RB cord-014516-r59usk02 119 37 when when WRB cord-014516-r59usk02 119 38 both both DT cord-014516-r59usk02 119 39 methods method NNS cord-014516-r59usk02 119 40 were be VBD cord-014516-r59usk02 119 41 referred refer VBN cord-014516-r59usk02 119 42 to to IN cord-014516-r59usk02 119 43 clinical clinical JJ cord-014516-r59usk02 119 44 scoring scoring NN cord-014516-r59usk02 119 45 . . . cord-014516-r59usk02 120 1 When when WRB cord-014516-r59usk02 120 2 the the DT cord-014516-r59usk02 120 3 presence presence NN cord-014516-r59usk02 120 4 of of IN cord-014516-r59usk02 120 5 additional additional JJ cord-014516-r59usk02 120 6 clinic clinic NN cord-014516-r59usk02 120 7 data datum NNS cord-014516-r59usk02 120 8 was be VBD cord-014516-r59usk02 120 9 also also RB cord-014516-r59usk02 120 10 included include VBN cord-014516-r59usk02 120 11 into into IN cord-014516-r59usk02 120 12 the the DT cord-014516-r59usk02 120 13 algorithm algorithm NN cord-014516-r59usk02 120 14 , , , cord-014516-r59usk02 120 15 the the DT cord-014516-r59usk02 120 16 sensitivity sensitivity NN cord-014516-r59usk02 120 17 increased increase VBD cord-014516-r59usk02 120 18 to to IN cord-014516-r59usk02 120 19 90.9 90.9 CD cord-014516-r59usk02 120 20 % % NN cord-014516-r59usk02 120 21 with with IN cord-014516-r59usk02 120 22 specificity specificity NN cord-014516-r59usk02 120 23 of of IN cord-014516-r59usk02 120 24 100 100 CD cord-014516-r59usk02 120 25 % % NN cord-014516-r59usk02 120 26 . . . cord-014516-r59usk02 121 1 The the DT cord-014516-r59usk02 121 2 data data NN cord-014516-r59usk02 121 3 suggests suggest VBZ cord-014516-r59usk02 121 4 that that IN cord-014516-r59usk02 121 5 test test NN cord-014516-r59usk02 121 6 performance performance NN cord-014516-r59usk02 121 7 for for IN cord-014516-r59usk02 121 8 canine canine JJ cord-014516-r59usk02 121 9 pancreatitis pancreatitis NN cord-014516-r59usk02 121 10 can can MD cord-014516-r59usk02 121 11 be be VB cord-014516-r59usk02 121 12 dramatically dramatically RB cord-014516-r59usk02 121 13 improved improve VBN cord-014516-r59usk02 121 14 when when WRB cord-014516-r59usk02 121 15 multiple multiple JJ cord-014516-r59usk02 121 16 diagnostic diagnostic JJ cord-014516-r59usk02 121 17 parameters parameter NNS cord-014516-r59usk02 121 18 are be VBP cord-014516-r59usk02 121 19 combined combine VBN cord-014516-r59usk02 121 20 using use VBG cord-014516-r59usk02 121 21 disease disease NN cord-014516-r59usk02 121 22 specific specific JJ cord-014516-r59usk02 121 23 algorithms algorithm NNS cord-014516-r59usk02 121 24 . . . cord-014516-r59usk02 122 1 The the DT cord-014516-r59usk02 122 2 author author NN cord-014516-r59usk02 122 3 receives receive VBZ cord-014516-r59usk02 122 4 a a DT cord-014516-r59usk02 122 5 salary salary NN cord-014516-r59usk02 122 6 as as IN cord-014516-r59usk02 122 7 Editor Editor NNP cord-014516-r59usk02 122 8 of of IN cord-014516-r59usk02 122 9 the the DT cord-014516-r59usk02 122 10 BSAVA BSAVA NNP cord-014516-r59usk02 122 11 journal journal NN cord-014516-r59usk02 122 12 Companion Companion NNP cord-014516-r59usk02 122 13 , , , cord-014516-r59usk02 122 14 and and CC cord-014516-r59usk02 122 15 has have VBZ cord-014516-r59usk02 122 16 undertaken undertake VBN cord-014516-r59usk02 122 17 unrelated unrelated JJ cord-014516-r59usk02 122 18 paid pay VBN cord-014516-r59usk02 122 19 consultancies consultancy NNS cord-014516-r59usk02 122 20 for for IN cord-014516-r59usk02 122 21 Bayer Bayer NNP cord-014516-r59usk02 122 22 and and CC cord-014516-r59usk02 122 23 Merial Merial NNP cord-014516-r59usk02 122 24 . . . cord-014516-r59usk02 123 1 The the DT cord-014516-r59usk02 123 2 author author NN cord-014516-r59usk02 123 3 also also RB cord-014516-r59usk02 123 4 receives receive VBZ cord-014516-r59usk02 123 5 a a DT cord-014516-r59usk02 123 6 salary salary NN cord-014516-r59usk02 123 7 from from IN cord-014516-r59usk02 123 8 Avacta Avacta NNP cord-014516-r59usk02 123 9 Animal Animal NNP cord-014516-r59usk02 123 10 Health Health NNP cord-014516-r59usk02 123 11 , , , cord-014516-r59usk02 123 12 and and CC cord-014516-r59usk02 123 13 duties duty NNS cord-014516-r59usk02 123 14 involved involve VBN cord-014516-r59usk02 123 15 working work VBG cord-014516-r59usk02 123 16 directly directly RB cord-014516-r59usk02 123 17 on on IN cord-014516-r59usk02 123 18 this this DT cord-014516-r59usk02 123 19 project project NN cord-014516-r59usk02 123 20 . . . cord-014516-r59usk02 124 1 Canine canine JJ cord-014516-r59usk02 124 2 chronic chronic NN cord-014516-r59usk02 124 3 enteropathy enteropathy NNP cord-014516-r59usk02 124 4 ( ( -LRB- cord-014516-r59usk02 124 5 CCE CCE NNP cord-014516-r59usk02 124 6 ) ) -RRB- cord-014516-r59usk02 124 7 can can MD cord-014516-r59usk02 124 8 cause cause VB cord-014516-r59usk02 124 9 significant significant JJ cord-014516-r59usk02 124 10 long long JJ cord-014516-r59usk02 124 11 - - HYPH cord-014516-r59usk02 124 12 term term NN cord-014516-r59usk02 124 13 morbidity morbidity NN cord-014516-r59usk02 124 14 . . . cord-014516-r59usk02 125 1 In in IN cord-014516-r59usk02 125 2 some some DT cord-014516-r59usk02 125 3 cases case NNS cord-014516-r59usk02 125 4 this this DT cord-014516-r59usk02 125 5 is be VBZ cord-014516-r59usk02 125 6 due due JJ cord-014516-r59usk02 125 7 to to IN cord-014516-r59usk02 125 8 intestinal intestinal JJ cord-014516-r59usk02 125 9 inflammation inflammation NN cord-014516-r59usk02 125 10 , , , cord-014516-r59usk02 125 11 resulting result VBG cord-014516-r59usk02 125 12 from from IN cord-014516-r59usk02 125 13 idiopathic idiopathic JJ cord-014516-r59usk02 125 14 inflammatory inflammatory JJ cord-014516-r59usk02 125 15 bowel bowel NN cord-014516-r59usk02 125 16 disease disease NN cord-014516-r59usk02 125 17 ( ( -LRB- cord-014516-r59usk02 125 18 IBD IBD NNP cord-014516-r59usk02 125 19 ) ) -RRB- cord-014516-r59usk02 125 20 . . . cord-014516-r59usk02 126 1 Currently currently RB cord-014516-r59usk02 126 2 , , , cord-014516-r59usk02 126 3 the the DT cord-014516-r59usk02 126 4 diagnosis diagnosis NN cord-014516-r59usk02 126 5 of of IN cord-014516-r59usk02 126 6 idiopathic idiopathic JJ cord-014516-r59usk02 126 7 IBD IBD NNP cord-014516-r59usk02 126 8 and and CC cord-014516-r59usk02 126 9 assessment assessment NN cord-014516-r59usk02 126 10 of of IN cord-014516-r59usk02 126 11 disease disease NN cord-014516-r59usk02 126 12 severity severity NN cord-014516-r59usk02 126 13 relies rely VBZ cord-014516-r59usk02 126 14 on on IN cord-014516-r59usk02 126 15 results result NNS cord-014516-r59usk02 126 16 of of IN cord-014516-r59usk02 126 17 subjective subjective JJ cord-014516-r59usk02 126 18 clinical clinical JJ cord-014516-r59usk02 126 19 indices index NNS cord-014516-r59usk02 126 20 , , , cord-014516-r59usk02 126 21 laboratory laboratory NN cord-014516-r59usk02 126 22 data datum NNS cord-014516-r59usk02 126 23 , , , cord-014516-r59usk02 126 24 diagnostic diagnostic JJ cord-014516-r59usk02 126 25 imaging imaging NN cord-014516-r59usk02 126 26 and and CC cord-014516-r59usk02 126 27 intestinal intestinal JJ cord-014516-r59usk02 126 28 histopathology histopathology NN cord-014516-r59usk02 126 29 , , , cord-014516-r59usk02 126 30 whilst whilst IN cord-014516-r59usk02 126 31 ruling rule VBG cord-014516-r59usk02 126 32 out out RP cord-014516-r59usk02 126 33 known know VBN cord-014516-r59usk02 126 34 causes cause NNS cord-014516-r59usk02 126 35 of of IN cord-014516-r59usk02 126 36 inflammation inflammation NN cord-014516-r59usk02 126 37 . . . cord-014516-r59usk02 127 1 In in IN cord-014516-r59usk02 127 2 humans human NNS cord-014516-r59usk02 127 3 with with IN cord-014516-r59usk02 127 4 IBD IBD NNP cord-014516-r59usk02 127 5 , , , cord-014516-r59usk02 127 6 a a DT cord-014516-r59usk02 127 7 number number NN cord-014516-r59usk02 127 8 of of IN cord-014516-r59usk02 127 9 faecal faecal JJ cord-014516-r59usk02 127 10 biomarkers biomarker NNS cord-014516-r59usk02 127 11 including include VBG cord-014516-r59usk02 127 12 lactoferrin lactoferrin NN cord-014516-r59usk02 127 13 , , , cord-014516-r59usk02 127 14 aid aid NN cord-014516-r59usk02 127 15 with with IN cord-014516-r59usk02 127 16 diagnosis diagnosis NN cord-014516-r59usk02 127 17 and and CC cord-014516-r59usk02 127 18 determining determine VBG cord-014516-r59usk02 127 19 disease disease NN cord-014516-r59usk02 127 20 activity activity NN cord-014516-r59usk02 127 21 . . . cord-014516-r59usk02 128 1 It -PRON- PRP cord-014516-r59usk02 128 2 may may MD cord-014516-r59usk02 128 3 therefore therefore RB cord-014516-r59usk02 128 4 be be VB cord-014516-r59usk02 128 5 valuable valuable JJ cord-014516-r59usk02 128 6 to to TO cord-014516-r59usk02 128 7 develop develop VB cord-014516-r59usk02 128 8 similar similar JJ cord-014516-r59usk02 128 9 non non JJ cord-014516-r59usk02 128 10 - - JJ cord-014516-r59usk02 128 11 invasive invasive JJ cord-014516-r59usk02 128 12 objective objective JJ cord-014516-r59usk02 128 13 methods method NNS cord-014516-r59usk02 128 14 to to TO cord-014516-r59usk02 128 15 aid aid VB cord-014516-r59usk02 128 16 diagnosis diagnosis NN cord-014516-r59usk02 128 17 and and CC cord-014516-r59usk02 128 18 clinical clinical JJ cord-014516-r59usk02 128 19 assessment assessment NN cord-014516-r59usk02 128 20 of of IN cord-014516-r59usk02 128 21 disease disease NN cord-014516-r59usk02 128 22 severity severity NN cord-014516-r59usk02 128 23 in in IN cord-014516-r59usk02 128 24 dogs dog NNS cord-014516-r59usk02 128 25 with with IN cord-014516-r59usk02 128 26 intestinal intestinal JJ cord-014516-r59usk02 128 27 inflammation inflammation NN cord-014516-r59usk02 128 28 due due JJ cord-014516-r59usk02 128 29 to to IN cord-014516-r59usk02 128 30 idiopathic idiopathic JJ cord-014516-r59usk02 128 31 IBD IBD NNP cord-014516-r59usk02 128 32 . . . cord-014516-r59usk02 129 1 This this DT cord-014516-r59usk02 129 2 pilot pilot NN cord-014516-r59usk02 129 3 study study NN cord-014516-r59usk02 129 4 aimed aim VBN cord-014516-r59usk02 129 5 to to TO cord-014516-r59usk02 129 6 measure measure VB cord-014516-r59usk02 129 7 faecal faecal JJ cord-014516-r59usk02 129 8 lactoferrin lactoferrin NN cord-014516-r59usk02 129 9 concentration concentration NN cord-014516-r59usk02 129 10 ( ( -LRB- cord-014516-r59usk02 129 11 FLC FLC NNP cord-014516-r59usk02 129 12 ) ) -RRB- cord-014516-r59usk02 129 13 in in IN cord-014516-r59usk02 129 14 dogs dog NNS cord-014516-r59usk02 129 15 with with IN cord-014516-r59usk02 129 16 CCE CCE NNP cord-014516-r59usk02 129 17 and and CC cord-014516-r59usk02 129 18 histologically histologically RB cord-014516-r59usk02 129 19 confirmed confirm VBD cord-014516-r59usk02 129 20 intestinal intestinal JJ cord-014516-r59usk02 129 21 inflammation inflammation NN cord-014516-r59usk02 129 22 ( ( -LRB- cord-014516-r59usk02 129 23 HCII HCII NNP cord-014516-r59usk02 129 24 ) ) -RRB- cord-014516-r59usk02 129 25 and and CC cord-014516-r59usk02 129 26 to to TO cord-014516-r59usk02 129 27 compare compare VB cord-014516-r59usk02 129 28 this this DT cord-014516-r59usk02 129 29 with with IN cord-014516-r59usk02 129 30 control control NN cord-014516-r59usk02 129 31 dogs dog NNS cord-014516-r59usk02 129 32 . . . cord-014516-r59usk02 130 1 In in IN cord-014516-r59usk02 130 2 addition addition NN cord-014516-r59usk02 130 3 , , , cord-014516-r59usk02 130 4 the the DT cord-014516-r59usk02 130 5 FLC FLC NNP cord-014516-r59usk02 130 6 in in IN cord-014516-r59usk02 130 7 dogs dog NNS cord-014516-r59usk02 130 8 with with IN cord-014516-r59usk02 130 9 HCII HCII NNP cord-014516-r59usk02 130 10 would would MD cord-014516-r59usk02 130 11 be be VB cord-014516-r59usk02 130 12 compared compare VBN cord-014516-r59usk02 130 13 with with IN cord-014516-r59usk02 130 14 the the DT cord-014516-r59usk02 130 15 canine canine JJ cord-014516-r59usk02 130 16 inflammatory inflammatory JJ cord-014516-r59usk02 130 17 bowel bowel NN cord-014516-r59usk02 130 18 disease disease NN cord-014516-r59usk02 130 19 activity activity NN cord-014516-r59usk02 130 20 index index NN cord-014516-r59usk02 130 21 ( ( -LRB- cord-014516-r59usk02 130 22 CIBDAI CIBDAI NNP cord-014516-r59usk02 130 23 ) ) -RRB- cord-014516-r59usk02 130 24 and and CC cord-014516-r59usk02 130 25 WSAVA WSAVA NNP cord-014516-r59usk02 130 26 standard standard JJ cord-014516-r59usk02 130 27 histopathological histopathological JJ cord-014516-r59usk02 130 28 criteria criterion NNS cord-014516-r59usk02 130 29 for for IN cord-014516-r59usk02 130 30 intestinal intestinal JJ cord-014516-r59usk02 130 31 inflammation inflammation NN cord-014516-r59usk02 130 32 to to TO cord-014516-r59usk02 130 33 determine determine VB cord-014516-r59usk02 130 34 whether whether IN cord-014516-r59usk02 130 35 there there EX cord-014516-r59usk02 130 36 was be VBD cord-014516-r59usk02 130 37 correlation correlation NN cord-014516-r59usk02 130 38 between between IN cord-014516-r59usk02 130 39 these these DT cord-014516-r59usk02 130 40 methods method NNS cord-014516-r59usk02 130 41 when when WRB cord-014516-r59usk02 130 42 assessing assess VBG cord-014516-r59usk02 130 43 disease disease NN cord-014516-r59usk02 130 44 severity severity NN cord-014516-r59usk02 130 45 . . . cord-014516-r59usk02 131 1 Faecal Faecal NNP cord-014516-r59usk02 131 2 samples sample NNS cord-014516-r59usk02 131 3 were be VBD cord-014516-r59usk02 131 4 obtained obtain VBN cord-014516-r59usk02 131 5 from from IN cord-014516-r59usk02 131 6 dogs dog NNS cord-014516-r59usk02 131 7 with with IN cord-014516-r59usk02 131 8 HCII HCII NNP cord-014516-r59usk02 131 9 ( ( -LRB- cord-014516-r59usk02 131 10 n n NN cord-014516-r59usk02 131 11 = = SYM cord-014516-r59usk02 131 12 13 13 CD cord-014516-r59usk02 131 13 ) ) -RRB- cord-014516-r59usk02 131 14 having have VBG cord-014516-r59usk02 131 15 undergone undergo VBN cord-014516-r59usk02 131 16 investigation investigation NN cord-014516-r59usk02 131 17 for for IN cord-014516-r59usk02 131 18 CCE CCE NNP cord-014516-r59usk02 131 19 ( ( -LRB- cord-014516-r59usk02 131 20 serum serum NN cord-014516-r59usk02 131 21 biochemistry biochemistry NN cord-014516-r59usk02 131 22 , , , cord-014516-r59usk02 131 23 complete complete VB cord-014516-r59usk02 131 24 blood blood NN cord-014516-r59usk02 131 25 count count NN cord-014516-r59usk02 131 26 , , , cord-014516-r59usk02 131 27 full full JJ cord-014516-r59usk02 131 28 faecal faecal JJ cord-014516-r59usk02 131 29 and and CC cord-014516-r59usk02 131 30 urinalysis urinalysis NN cord-014516-r59usk02 131 31 , , , cord-014516-r59usk02 131 32 serum serum NN cord-014516-r59usk02 131 33 cobalamin cobalamin NN cord-014516-r59usk02 131 34 , , , cord-014516-r59usk02 131 35 quantitative quantitative JJ cord-014516-r59usk02 131 36 cPLI cpli NN cord-014516-r59usk02 131 37 , , , cord-014516-r59usk02 131 38 abdominal abdominal JJ cord-014516-r59usk02 131 39 ultrasound ultrasound NN cord-014516-r59usk02 131 40 and and CC cord-014516-r59usk02 131 41 intestinal intestinal JJ cord-014516-r59usk02 131 42 biopsies biopsy NNS cord-014516-r59usk02 131 43 ) ) -RRB- cord-014516-r59usk02 131 44 . . . cord-014516-r59usk02 132 1 The the DT cord-014516-r59usk02 132 2 control control NN cord-014516-r59usk02 132 3 population population NN cord-014516-r59usk02 132 4 were be VBD cord-014516-r59usk02 132 5 dogs dog NNS cord-014516-r59usk02 132 6 presented present VBN cord-014516-r59usk02 132 7 for for IN cord-014516-r59usk02 132 8 reasons reason NNS cord-014516-r59usk02 132 9 unrelated unrelated JJ cord-014516-r59usk02 132 10 to to IN cord-014516-r59usk02 132 11 CCE CCE NNP cord-014516-r59usk02 132 12 ( ( -LRB- cord-014516-r59usk02 132 13 n n NN cord-014516-r59usk02 132 14 = = SYM cord-014516-r59usk02 132 15 7 7 CD cord-014516-r59usk02 132 16 ) ) -RRB- cord-014516-r59usk02 132 17 . . . cord-014516-r59usk02 133 1 Analysis analysis NN cord-014516-r59usk02 133 2 was be VBD cord-014516-r59usk02 133 3 carried carry VBN cord-014516-r59usk02 133 4 out out RP cord-014516-r59usk02 133 5 using use VBG cord-014516-r59usk02 133 6 a a DT cord-014516-r59usk02 133 7 faecal faecal JJ cord-014516-r59usk02 133 8 lactoferrin lactoferrin NNP cord-014516-r59usk02 133 9 ELISA ELISA NNP cord-014516-r59usk02 133 10 previously previously RB cord-014516-r59usk02 133 11 validated validate VBD cord-014516-r59usk02 133 12 in in IN cord-014516-r59usk02 133 13 dogs dog NNS cord-014516-r59usk02 133 14 ( ( -LRB- cord-014516-r59usk02 133 15 TechLab TechLab NNP cord-014516-r59usk02 133 16 , , , cord-014516-r59usk02 133 17 USA USA NNP cord-014516-r59usk02 133 18 ) ) -RRB- cord-014516-r59usk02 133 19 . . . cord-014516-r59usk02 134 1 The the DT cord-014516-r59usk02 134 2 FLC FLC NNP cord-014516-r59usk02 134 3 in in IN cord-014516-r59usk02 134 4 dogs dog NNS cord-014516-r59usk02 134 5 with with IN cord-014516-r59usk02 134 6 HCII HCII NNP cord-014516-r59usk02 134 7 ( ( -LRB- cord-014516-r59usk02 134 8 median median JJ cord-014516-r59usk02 134 9 9.79 9.79 CD cord-014516-r59usk02 134 10 lg lg NNP cord-014516-r59usk02 134 11 / / SYM cord-014516-r59usk02 134 12 g g NNP cord-014516-r59usk02 134 13 -range -range VBD cord-014516-r59usk02 134 14 0.47 0.47 CD cord-014516-r59usk02 134 15 to to IN cord-014516-r59usk02 134 16 150.2 150.2 CD cord-014516-r59usk02 134 17 ) ) -RRB- cord-014516-r59usk02 134 18 was be VBD cord-014516-r59usk02 134 19 significantly significantly RB cord-014516-r59usk02 134 20 higher high JJR cord-014516-r59usk02 134 21 than than IN cord-014516-r59usk02 134 22 control control NN cord-014516-r59usk02 134 23 dogs dog NNS cord-014516-r59usk02 134 24 ( ( -LRB- cord-014516-r59usk02 134 25 median median JJ cord-014516-r59usk02 134 26 0.75 0.75 CD cord-014516-r59usk02 134 27 lg lg NNP cord-014516-r59usk02 134 28 / / SYM cord-014516-r59usk02 134 29 g g NNP cord-014516-r59usk02 134 30 -range -range HYPH cord-014516-r59usk02 134 31 0.12 0.12 CD cord-014516-r59usk02 134 32 - - SYM cord-014516-r59usk02 134 33 4.14 4.14 CD cord-014516-r59usk02 134 34 ) ) -RRB- cord-014516-r59usk02 135 1 ( ( -LRB- cord-014516-r59usk02 135 2 P p NN cord-014516-r59usk02 135 3 < < XX cord-014516-r59usk02 135 4 0.003 0.003 CD cord-014516-r59usk02 135 5 ) ) -RRB- cord-014516-r59usk02 135 6 . . . cord-014516-r59usk02 136 1 A a DT cord-014516-r59usk02 136 2 cut cut VB cord-014516-r59usk02 136 3 - - HYPH cord-014516-r59usk02 136 4 off off RP cord-014516-r59usk02 136 5 FLC FLC NNP cord-014516-r59usk02 136 6 of of IN cord-014516-r59usk02 136 7 4.5 4.5 CD cord-014516-r59usk02 136 8 lg lg NNP cord-014516-r59usk02 136 9 / / SYM cord-014516-r59usk02 136 10 g g NNP cord-014516-r59usk02 136 11 correctly correctly RB cord-014516-r59usk02 136 12 identified identify VBD cord-014516-r59usk02 136 13 10/13 10/13 CD cord-014516-r59usk02 136 14 ( ( -LRB- cord-014516-r59usk02 136 15 77 77 CD cord-014516-r59usk02 136 16 % % NN cord-014516-r59usk02 136 17 ) ) -RRB- cord-014516-r59usk02 136 18 of of IN cord-014516-r59usk02 136 19 dogs dog NNS cord-014516-r59usk02 136 20 with with IN cord-014516-r59usk02 136 21 HCII HCII NNP cord-014516-r59usk02 136 22 . . . cord-014516-r59usk02 137 1 Using use VBG cord-014516-r59usk02 137 2 this this DT cord-014516-r59usk02 137 3 cut cut NN cord-014516-r59usk02 137 4 - - HYPH cord-014516-r59usk02 137 5 off off RP cord-014516-r59usk02 137 6 , , , cord-014516-r59usk02 137 7 there there EX cord-014516-r59usk02 137 8 was be VBD cord-014516-r59usk02 137 9 no no DT cord-014516-r59usk02 137 10 overlap overlap NN cord-014516-r59usk02 137 11 between between IN cord-014516-r59usk02 137 12 non non JJ cord-014516-r59usk02 137 13 - - JJ cord-014516-r59usk02 137 14 CCE cce JJ cord-014516-r59usk02 137 15 dogs dog NNS cord-014516-r59usk02 137 16 FLC FLC NNP cord-014516-r59usk02 137 17 and and CC cord-014516-r59usk02 137 18 the the DT cord-014516-r59usk02 137 19 HCII HCII NNP cord-014516-r59usk02 137 20 group group NN cord-014516-r59usk02 137 21 ; ; : cord-014516-r59usk02 137 22 giving give VBG cord-014516-r59usk02 137 23 a a DT cord-014516-r59usk02 137 24 sensitivity sensitivity NN cord-014516-r59usk02 137 25 of of IN cord-014516-r59usk02 137 26 76 76 CD cord-014516-r59usk02 137 27 % % NN cord-014516-r59usk02 137 28 and and CC cord-014516-r59usk02 137 29 specificity specificity NN cord-014516-r59usk02 137 30 of of IN cord-014516-r59usk02 137 31 100 100 CD cord-014516-r59usk02 137 32 % % NN cord-014516-r59usk02 137 33 . . . cord-014516-r59usk02 138 1 Neither neither CC cord-014516-r59usk02 138 2 the the DT cord-014516-r59usk02 138 3 presence presence NN cord-014516-r59usk02 138 4 of of IN cord-014516-r59usk02 138 5 neutrophils neutrophil NNS cord-014516-r59usk02 138 6 nor nor CC cord-014516-r59usk02 138 7 the the DT cord-014516-r59usk02 138 8 extent extent NN cord-014516-r59usk02 138 9 of of IN cord-014516-r59usk02 138 10 inflammation inflammation NN cord-014516-r59usk02 138 11 on on IN cord-014516-r59usk02 138 12 histopathology histopathology NN cord-014516-r59usk02 138 13 showed show VBD cord-014516-r59usk02 138 14 significant significant JJ cord-014516-r59usk02 138 15 correlation correlation NN cord-014516-r59usk02 138 16 with with IN cord-014516-r59usk02 138 17 FLC FLC NNP cord-014516-r59usk02 138 18 . . . cord-014516-r59usk02 139 1 The the DT cord-014516-r59usk02 139 2 CIBDAI CIBDAI NNP cord-014516-r59usk02 139 3 showed show VBD cord-014516-r59usk02 139 4 moderate moderate JJ cord-014516-r59usk02 139 5 correlation correlation NN cord-014516-r59usk02 139 6 with with IN cord-014516-r59usk02 139 7 FLC FLC NNP cord-014516-r59usk02 139 8 in in IN cord-014516-r59usk02 139 9 dogs dog NNS cord-014516-r59usk02 139 10 with with IN cord-014516-r59usk02 139 11 HCII HCII NNP cord-014516-r59usk02 140 1 ( ( -LRB- cord-014516-r59usk02 140 2 r r NN cord-014516-r59usk02 140 3 = = SYM cord-014516-r59usk02 140 4 0.79 0.79 CD cord-014516-r59usk02 140 5 , , , cord-014516-r59usk02 140 6 P p NN cord-014516-r59usk02 140 7 = = SYM cord-014516-r59usk02 140 8 0.05 0.05 CD cord-014516-r59usk02 140 9 ) ) -RRB- cord-014516-r59usk02 140 10 . . . cord-014516-r59usk02 141 1 The the DT cord-014516-r59usk02 141 2 results result NNS cord-014516-r59usk02 141 3 of of IN cord-014516-r59usk02 141 4 this this DT cord-014516-r59usk02 141 5 pilot pilot NN cord-014516-r59usk02 141 6 study study NN cord-014516-r59usk02 141 7 suggest suggest VBP cord-014516-r59usk02 141 8 that that IN cord-014516-r59usk02 141 9 FLC FLC NNP cord-014516-r59usk02 141 10 is be VBZ cord-014516-r59usk02 141 11 able able JJ cord-014516-r59usk02 141 12 to to TO cord-014516-r59usk02 141 13 discriminate discriminate VB cord-014516-r59usk02 141 14 between between IN cord-014516-r59usk02 141 15 dogs dog NNS cord-014516-r59usk02 141 16 with with IN cord-014516-r59usk02 141 17 CCE CCE NNP cord-014516-r59usk02 141 18 due due JJ cord-014516-r59usk02 141 19 to to IN cord-014516-r59usk02 141 20 HCII HCII NNP cord-014516-r59usk02 141 21 and and CC cord-014516-r59usk02 141 22 dogs dog NNS cord-014516-r59usk02 141 23 without without IN cord-014516-r59usk02 141 24 CCE CCE NNP cord-014516-r59usk02 141 25 . . . cord-014516-r59usk02 142 1 It -PRON- PRP cord-014516-r59usk02 142 2 is be VBZ cord-014516-r59usk02 142 3 possible possible JJ cord-014516-r59usk02 142 4 that that IN cord-014516-r59usk02 142 5 incorporating incorporate VBG cord-014516-r59usk02 142 6 FLC FLC NNP cord-014516-r59usk02 142 7 into into IN cord-014516-r59usk02 142 8 a a DT cord-014516-r59usk02 142 9 panel panel NN cord-014516-r59usk02 142 10 of of IN cord-014516-r59usk02 142 11 faecal faecal JJ cord-014516-r59usk02 142 12 biomarkers biomarker NNS cord-014516-r59usk02 142 13 will will MD cord-014516-r59usk02 142 14 enable enable VB cord-014516-r59usk02 142 15 non non JJ cord-014516-r59usk02 142 16 - - JJ cord-014516-r59usk02 142 17 invasive invasive JJ cord-014516-r59usk02 142 18 assessment assessment NN cord-014516-r59usk02 142 19 of of IN cord-014516-r59usk02 142 20 HCII HCII NNP cord-014516-r59usk02 142 21 and and CC cord-014516-r59usk02 142 22 could could MD cord-014516-r59usk02 142 23 serve serve VB cord-014516-r59usk02 142 24 as as IN cord-014516-r59usk02 142 25 an an DT cord-014516-r59usk02 142 26 adjunct adjunct NN cord-014516-r59usk02 142 27 to to IN cord-014516-r59usk02 142 28 current current JJ cord-014516-r59usk02 142 29 measures measure NNS cord-014516-r59usk02 142 30 of of IN cord-014516-r59usk02 142 31 disease disease NN cord-014516-r59usk02 142 32 severity severity NN cord-014516-r59usk02 142 33 in in IN cord-014516-r59usk02 142 34 dogs dog NNS cord-014516-r59usk02 142 35 with with IN cord-014516-r59usk02 142 36 idiopathic idiopathic JJ cord-014516-r59usk02 142 37 IBD IBD NNP cord-014516-r59usk02 142 38 . . . cord-014516-r59usk02 143 1 Ryan Ryan NNP cord-014516-r59usk02 143 2 Bettencourt Bettencourt NNP cord-014516-r59usk02 143 3 and and CC cord-014516-r59usk02 143 4 James James NNP cord-014516-r59usk02 143 5 Boone Boone NNP cord-014516-r59usk02 143 6 are be VBP cord-014516-r59usk02 143 7 employees employee NNS cord-014516-r59usk02 143 8 of of IN cord-014516-r59usk02 143 9 TechLab TechLab NNP cord-014516-r59usk02 143 10 , , , cord-014516-r59usk02 143 11 USA USA NNP cord-014516-r59usk02 143 12 . . . cord-014516-r59usk02 144 1 They -PRON- PRP cord-014516-r59usk02 144 2 provided provide VBD cord-014516-r59usk02 144 3 the the DT cord-014516-r59usk02 144 4 ELISA ELISA NNP cord-014516-r59usk02 144 5 kits kit NNS cord-014516-r59usk02 144 6 free free JJ cord-014516-r59usk02 144 7 of of IN cord-014516-r59usk02 144 8 charge charge NN cord-014516-r59usk02 144 9 for for IN cord-014516-r59usk02 144 10 this this DT cord-014516-r59usk02 144 11 work work NN cord-014516-r59usk02 144 12 . . . cord-014516-r59usk02 145 1 There there EX cord-014516-r59usk02 145 2 was be VBD cord-014516-r59usk02 145 3 no no DT cord-014516-r59usk02 145 4 other other JJ cord-014516-r59usk02 145 5 incentive incentive NN cord-014516-r59usk02 145 6 provided provide VBN cord-014516-r59usk02 145 7 and and CC cord-014516-r59usk02 145 8 the the DT cord-014516-r59usk02 145 9 results result NNS cord-014516-r59usk02 145 10 have have VBP cord-014516-r59usk02 145 11 been be VBN cord-014516-r59usk02 145 12 openly openly RB cord-014516-r59usk02 145 13 discussed discuss VBN cord-014516-r59usk02 145 14 between between IN cord-014516-r59usk02 145 15 all all DT cord-014516-r59usk02 145 16 parties party NNS cord-014516-r59usk02 145 17 . . . cord-014516-r59usk02 146 1 There there EX cord-014516-r59usk02 146 2 has have VBZ cord-014516-r59usk02 146 3 been be VBN cord-014516-r59usk02 146 4 no no DT cord-014516-r59usk02 146 5 censorship censorship NN cord-014516-r59usk02 146 6 placed place VBN cord-014516-r59usk02 146 7 on on IN cord-014516-r59usk02 146 8 the the DT cord-014516-r59usk02 146 9 results result NNS cord-014516-r59usk02 146 10 by by IN cord-014516-r59usk02 146 11 Tech Tech NNP cord-014516-r59usk02 146 12 - - HYPH cord-014516-r59usk02 146 13 Lab Lab NNP cord-014516-r59usk02 146 14 and and CC cord-014516-r59usk02 146 15 they -PRON- PRP cord-014516-r59usk02 146 16 have have VBP cord-014516-r59usk02 146 17 been be VBN cord-014516-r59usk02 146 18 supportive supportive JJ cord-014516-r59usk02 146 19 of of IN cord-014516-r59usk02 146 20 the the DT cord-014516-r59usk02 146 21 work work NN cord-014516-r59usk02 146 22 and and CC cord-014516-r59usk02 146 23 submission submission NN cord-014516-r59usk02 146 24 of of IN cord-014516-r59usk02 146 25 this this DT cord-014516-r59usk02 146 26 abstract abstract NN cord-014516-r59usk02 146 27 . . . cord-014516-r59usk02 147 1 There there EX cord-014516-r59usk02 147 2 are be VBP cord-014516-r59usk02 147 3 no no DT cord-014516-r59usk02 147 4 other other JJ cord-014516-r59usk02 147 5 conflicts conflict NNS cord-014516-r59usk02 147 6 to to TO cord-014516-r59usk02 147 7 disclose disclose VB cord-014516-r59usk02 147 8 . . . cord-014516-r59usk02 148 1 Fecal fecal JJ cord-014516-r59usk02 148 2 S100A12 s100a12 NN cord-014516-r59usk02 148 3 and and CC cord-014516-r59usk02 148 4 fecal fecal JJ cord-014516-r59usk02 148 5 calprotectin calprotectin NN cord-014516-r59usk02 148 6 concentrations concentration NNS cord-014516-r59usk02 148 7 have have VBP cord-014516-r59usk02 148 8 been be VBN cord-014516-r59usk02 148 9 described describe VBN cord-014516-r59usk02 148 10 as as IN cord-014516-r59usk02 148 11 biomarkers biomarker NNS cord-014516-r59usk02 148 12 in in IN cord-014516-r59usk02 148 13 dogs dog NNS cord-014516-r59usk02 148 14 with with IN cord-014516-r59usk02 148 15 chronic chronic JJ cord-014516-r59usk02 148 16 enteropathies enteropathy NNS cord-014516-r59usk02 148 17 [ [ -LRB- cord-014516-r59usk02 148 18 1 1 CD cord-014516-r59usk02 148 19 ] ] -RRB- cord-014516-r59usk02 148 20 . . . cord-014516-r59usk02 149 1 However however RB cord-014516-r59usk02 149 2 , , , cord-014516-r59usk02 149 3 to to IN cord-014516-r59usk02 149 4 date date NN cord-014516-r59usk02 149 5 there there EX cord-014516-r59usk02 149 6 has have VBZ cord-014516-r59usk02 149 7 been be VBN cord-014516-r59usk02 149 8 no no DT cord-014516-r59usk02 149 9 direct direct JJ cord-014516-r59usk02 149 10 comparison comparison NN cord-014516-r59usk02 149 11 of of IN cord-014516-r59usk02 149 12 these these DT cord-014516-r59usk02 149 13 two two CD cord-014516-r59usk02 149 14 markers marker NNS cord-014516-r59usk02 149 15 in in IN cord-014516-r59usk02 149 16 dogs dog NNS cord-014516-r59usk02 149 17 with with IN cord-014516-r59usk02 149 18 chronic chronic JJ cord-014516-r59usk02 149 19 diarrhea diarrhea NN cord-014516-r59usk02 149 20 . . . cord-014516-r59usk02 150 1 The the DT cord-014516-r59usk02 150 2 aim aim NN cord-014516-r59usk02 150 3 of of IN cord-014516-r59usk02 150 4 this this DT cord-014516-r59usk02 150 5 study study NN cord-014516-r59usk02 150 6 was be VBD cord-014516-r59usk02 150 7 to to TO cord-014516-r59usk02 150 8 evaluate evaluate VB cord-014516-r59usk02 150 9 the the DT cord-014516-r59usk02 150 10 performance performance NN cord-014516-r59usk02 150 11 of of IN cord-014516-r59usk02 150 12 these these DT cord-014516-r59usk02 150 13 two two CD cord-014516-r59usk02 150 14 markers marker NNS cord-014516-r59usk02 150 15 in in IN cord-014516-r59usk02 150 16 this this DT cord-014516-r59usk02 150 17 situation situation NN cord-014516-r59usk02 150 18 . . . cord-014516-r59usk02 151 1 Thirty thirty CD cord-014516-r59usk02 151 2 one one CD cord-014516-r59usk02 151 3 dogs dog NNS cord-014516-r59usk02 151 4 presented present VBN cord-014516-r59usk02 151 5 for for IN cord-014516-r59usk02 151 6 a a DT cord-014516-r59usk02 151 7 history history NN cord-014516-r59usk02 151 8 of of IN cord-014516-r59usk02 151 9 chronic chronic JJ cord-014516-r59usk02 151 10 diarrhea diarrhea NN cord-014516-r59usk02 151 11 were be VBD cord-014516-r59usk02 151 12 prospectively prospectively RB cord-014516-r59usk02 151 13 enrolled enrol VBN cord-014516-r59usk02 151 14 . . . cord-014516-r59usk02 152 1 The the DT cord-014516-r59usk02 152 2 initial initial JJ cord-014516-r59usk02 152 3 diagnostic diagnostic JJ cord-014516-r59usk02 152 4 workup workup NN cord-014516-r59usk02 152 5 for for IN cord-014516-r59usk02 152 6 all all DT cord-014516-r59usk02 152 7 patients patient NNS cord-014516-r59usk02 152 8 included include VBD cord-014516-r59usk02 152 9 a a DT cord-014516-r59usk02 152 10 serum serum NN cord-014516-r59usk02 152 11 biochemistry biochemistry NN cord-014516-r59usk02 152 12 profile profile NN cord-014516-r59usk02 152 13 , , , cord-014516-r59usk02 152 14 fecal fecal JJ cord-014516-r59usk02 152 15 parasitology parasitology NN cord-014516-r59usk02 152 16 , , , cord-014516-r59usk02 152 17 abdominal abdominal JJ cord-014516-r59usk02 152 18 ultrasound ultrasound NN cord-014516-r59usk02 152 19 examination examination NN cord-014516-r59usk02 152 20 , , , cord-014516-r59usk02 152 21 and and CC cord-014516-r59usk02 152 22 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 152 23 endoscopy endoscopy NN cord-014516-r59usk02 152 24 with with IN cord-014516-r59usk02 152 25 collection collection NN cord-014516-r59usk02 152 26 of of IN cord-014516-r59usk02 152 27 endoscopic endoscopic JJ cord-014516-r59usk02 152 28 biopsies biopsy NNS cord-014516-r59usk02 152 29 . . . cord-014516-r59usk02 153 1 The the DT cord-014516-r59usk02 153 2 severity severity NN cord-014516-r59usk02 153 3 of of IN cord-014516-r59usk02 153 4 clinical clinical JJ cord-014516-r59usk02 153 5 signs sign NNS cord-014516-r59usk02 153 6 was be VBD cord-014516-r59usk02 153 7 evaluated evaluate VBN cord-014516-r59usk02 153 8 using use VBG cord-014516-r59usk02 153 9 the the DT cord-014516-r59usk02 153 10 CCECAI CCECAI NNP cord-014516-r59usk02 153 11 scoring score VBG cord-014516-r59usk02 153 12 index index NN cord-014516-r59usk02 153 13 and and CC cord-014516-r59usk02 153 14 patients patient NNS cord-014516-r59usk02 153 15 were be VBD cord-014516-r59usk02 153 16 grouped group VBN cord-014516-r59usk02 153 17 by by IN cord-014516-r59usk02 153 18 having have VBG cord-014516-r59usk02 153 19 a a DT cord-014516-r59usk02 153 20 CCECAI CCECAI NNP cord-014516-r59usk02 153 21 of of IN cord-014516-r59usk02 153 22 < < NNP cord-014516-r59usk02 153 23 12 12 CD cord-014516-r59usk02 153 24 or or CC cord-014516-r59usk02 153 25 ≥ ≥ CD cord-014516-r59usk02 153 26 12 12 CD cord-014516-r59usk02 153 27 . . . cord-014516-r59usk02 154 1 Fecal fecal JJ cord-014516-r59usk02 154 2 calprotectin calprotectin NNS cord-014516-r59usk02 154 3 and and CC cord-014516-r59usk02 154 4 S100A12 S100A12 NNS cord-014516-r59usk02 154 5 were be VBD cord-014516-r59usk02 154 6 quantified quantify VBN cord-014516-r59usk02 154 7 as as IN cord-014516-r59usk02 154 8 previously previously RB cord-014516-r59usk02 154 9 described describe VBN cord-014516-r59usk02 154 10 [ [ -LRB- cord-014516-r59usk02 154 11 1 1 CD cord-014516-r59usk02 154 12 ] ] -RRB- cord-014516-r59usk02 154 13 . . . cord-014516-r59usk02 155 1 Correlations correlation NNS cord-014516-r59usk02 155 2 were be VBD cord-014516-r59usk02 155 3 evaluated evaluate VBN cord-014516-r59usk02 155 4 with with IN cord-014516-r59usk02 155 5 the the DT cord-014516-r59usk02 155 6 Spearman Spearman NNP cord-014516-r59usk02 155 7 rank rank NN cord-014516-r59usk02 155 8 correlation correlation NN cord-014516-r59usk02 155 9 test test NN cord-014516-r59usk02 155 10 . . . cord-014516-r59usk02 156 1 For for IN cord-014516-r59usk02 156 2 both both DT cord-014516-r59usk02 156 3 markers marker NNS cord-014516-r59usk02 156 4 a a DT cord-014516-r59usk02 156 5 receiver receiver NN cord-014516-r59usk02 156 6 operating operate VBG cord-014516-r59usk02 156 7 characteristics characteristic NNS cord-014516-r59usk02 156 8 ( ( -LRB- cord-014516-r59usk02 156 9 ROC ROC NNP cord-014516-r59usk02 156 10 ) ) -RRB- cord-014516-r59usk02 156 11 curve curve NN cord-014516-r59usk02 156 12 was be VBD cord-014516-r59usk02 156 13 used use VBN cord-014516-r59usk02 156 14 to to TO cord-014516-r59usk02 156 15 select select VB cord-014516-r59usk02 156 16 cut cut VB cord-014516-r59usk02 156 17 - - HYPH cord-014516-r59usk02 156 18 off off RP cord-014516-r59usk02 156 19 value value NN cord-014516-r59usk02 156 20 that that WDT cord-014516-r59usk02 156 21 allowed allow VBD cord-014516-r59usk02 156 22 the the DT cord-014516-r59usk02 156 23 best good JJS cord-014516-r59usk02 156 24 discrimination discrimination NN cord-014516-r59usk02 156 25 between between IN cord-014516-r59usk02 156 26 dogs dog NNS cord-014516-r59usk02 156 27 with with IN cord-014516-r59usk02 156 28 a a DT cord-014516-r59usk02 156 29 CCECAI<12 ccecai<12 NN cord-014516-r59usk02 156 30 and and CC cord-014516-r59usk02 156 31 dogs dog NNS cord-014516-r59usk02 156 32 with with IN cord-014516-r59usk02 156 33 a a DT cord-014516-r59usk02 156 34 CCECAI CCECAI NNP cord-014516-r59usk02 156 35 ≥ ≥ CD cord-014516-r59usk02 156 36 12 12 CD cord-014516-r59usk02 156 37 . . . cord-014516-r59usk02 157 1 Sensitivity sensitivity NN cord-014516-r59usk02 157 2 and and CC cord-014516-r59usk02 157 3 specificity specificity NN cord-014516-r59usk02 157 4 were be VBD cord-014516-r59usk02 157 5 calculated calculate VBN cord-014516-r59usk02 157 6 . . . cord-014516-r59usk02 158 1 Correlation correlation NN cord-014516-r59usk02 158 2 analyses analysis NNS cord-014516-r59usk02 158 3 revealed reveal VBD cord-014516-r59usk02 158 4 a a DT cord-014516-r59usk02 158 5 significant significant JJ cord-014516-r59usk02 158 6 positive positive JJ cord-014516-r59usk02 158 7 correlation correlation NN cord-014516-r59usk02 158 8 between between IN cord-014516-r59usk02 158 9 S100A12 s100a12 NN cord-014516-r59usk02 158 10 and and CC cord-014516-r59usk02 158 11 calprotectin calprotectin NNP cord-014516-r59usk02 158 12 ( ( -LRB- cord-014516-r59usk02 158 13 r r NN cord-014516-r59usk02 158 14 = = SYM cord-014516-r59usk02 158 15 0.77 0.77 CD cord-014516-r59usk02 158 16 ; ; : cord-014516-r59usk02 158 17 p p NN cord-014516-r59usk02 158 18 < < XX cord-014516-r59usk02 158 19 0.001 0.001 CD cord-014516-r59usk02 158 20 ) ) -RRB- cord-014516-r59usk02 158 21 . . . cord-014516-r59usk02 159 1 The the DT cord-014516-r59usk02 159 2 optimal optimal JJ cord-014516-r59usk02 159 3 cut cut VB cord-014516-r59usk02 159 4 - - HYPH cord-014516-r59usk02 159 5 off off RP cord-014516-r59usk02 159 6 value value NN cord-014516-r59usk02 159 7 for for IN cord-014516-r59usk02 159 8 fecal fecal JJ cord-014516-r59usk02 159 9 calprotectin calprotectin NN cord-014516-r59usk02 159 10 concentration concentration NN cord-014516-r59usk02 159 11 was be VBD cord-014516-r59usk02 159 12 49.1 49.1 CD cord-014516-r59usk02 159 13 lg lg NNP cord-014516-r59usk02 159 14 / / SYM cord-014516-r59usk02 159 15 g g NNP cord-014516-r59usk02 159 16 , , , cord-014516-r59usk02 159 17 which which WDT cord-014516-r59usk02 159 18 was be VBD cord-014516-r59usk02 159 19 associated associate VBN cord-014516-r59usk02 159 20 with with IN cord-014516-r59usk02 159 21 a a DT cord-014516-r59usk02 159 22 sensitivity sensitivity NN cord-014516-r59usk02 159 23 of of IN cord-014516-r59usk02 159 24 53.3 53.3 CD cord-014516-r59usk02 159 25 % % NN cord-014516-r59usk02 159 26 and and CC cord-014516-r59usk02 159 27 a a DT cord-014516-r59usk02 159 28 specificity specificity NN cord-014516-r59usk02 159 29 of of IN cord-014516-r59usk02 159 30 86.7 86.7 CD cord-014516-r59usk02 159 31 % % NN cord-014516-r59usk02 159 32 ( ( -LRB- cord-014516-r59usk02 159 33 AUC=0.698 auc=0.698 NN cord-014516-r59usk02 159 34 ; ; : cord-014516-r59usk02 159 35 P p NN cord-014516-r59usk02 159 36 = = SYM cord-014516-r59usk02 159 37 0.049 0.049 CD cord-014516-r59usk02 159 38 ) ) -RRB- cord-014516-r59usk02 159 39 . . . cord-014516-r59usk02 160 1 The the DT cord-014516-r59usk02 160 2 optimal optimal JJ cord-014516-r59usk02 160 3 cutoff cutoff NN cord-014516-r59usk02 160 4 value value NN cord-014516-r59usk02 160 5 for for IN cord-014516-r59usk02 160 6 fecal fecal JJ cord-014516-r59usk02 160 7 S100A12 s100a12 NN cord-014516-r59usk02 160 8 concentration concentration NN cord-014516-r59usk02 160 9 was be VBD cord-014516-r59usk02 160 10 173.7 173.7 CD cord-014516-r59usk02 160 11 ng ng NN cord-014516-r59usk02 160 12 / / SYM cord-014516-r59usk02 160 13 g g NN cord-014516-r59usk02 160 14 , , , cord-014516-r59usk02 160 15 which which WDT cord-014516-r59usk02 160 16 was be VBD cord-014516-r59usk02 160 17 associated associate VBN cord-014516-r59usk02 160 18 with with IN cord-014516-r59usk02 160 19 a a DT cord-014516-r59usk02 160 20 sensitivity sensitivity NN cord-014516-r59usk02 160 21 of of IN cord-014516-r59usk02 160 22 93.3 93.3 CD cord-014516-r59usk02 160 23 % % NN cord-014516-r59usk02 160 24 and and CC cord-014516-r59usk02 160 25 a a DT cord-014516-r59usk02 160 26 specificity specificity NN cord-014516-r59usk02 160 27 of of IN cord-014516-r59usk02 160 28 60 60 CD cord-014516-r59usk02 160 29 % % NN cord-014516-r59usk02 160 30 ( ( -LRB- cord-014516-r59usk02 160 31 AUC=0.782 AUC=0.782 NNP cord-014516-r59usk02 160 32 ; ; : cord-014516-r59usk02 160 33 P p NN cord-014516-r59usk02 160 34 = = SYM cord-014516-r59usk02 160 35 0.001 0.001 CD cord-014516-r59usk02 160 36 ) ) -RRB- cord-014516-r59usk02 160 37 . . . cord-014516-r59usk02 161 1 The the DT cord-014516-r59usk02 161 2 sensitivity sensitivity NN cord-014516-r59usk02 161 3 for for IN cord-014516-r59usk02 161 4 fecal fecal JJ cord-014516-r59usk02 161 5 S100A12 s100a12 NN cord-014516-r59usk02 161 6 was be VBD cord-014516-r59usk02 161 7 higher high JJR cord-014516-r59usk02 161 8 than than IN cord-014516-r59usk02 161 9 that that DT cord-014516-r59usk02 161 10 for for IN cord-014516-r59usk02 161 11 fecal fecal JJ cord-014516-r59usk02 161 12 calprotectin calprotectin NNP cord-014516-r59usk02 161 13 ( ( -LRB- cord-014516-r59usk02 161 14 p p NN cord-014516-r59usk02 161 15 = = SYM cord-014516-r59usk02 161 16 0.019 0.019 CD cord-014516-r59usk02 161 17 ) ) -RRB- cord-014516-r59usk02 161 18 . . . cord-014516-r59usk02 162 1 No no DT cord-014516-r59usk02 162 2 significant significant JJ cord-014516-r59usk02 162 3 difference difference NN cord-014516-r59usk02 162 4 was be VBD cord-014516-r59usk02 162 5 observed observe VBN cord-014516-r59usk02 162 6 for for IN cord-014516-r59usk02 162 7 the the DT cord-014516-r59usk02 162 8 specificity specificity NN cord-014516-r59usk02 162 9 of of IN cord-014516-r59usk02 162 10 these these DT cord-014516-r59usk02 162 11 two two CD cord-014516-r59usk02 162 12 markers marker NNS cord-014516-r59usk02 162 13 ( ( -LRB- cord-014516-r59usk02 162 14 p p NN cord-014516-r59usk02 162 15 = = SYM cord-014516-r59usk02 162 16 0.215 0.215 CD cord-014516-r59usk02 162 17 ) ) -RRB- cord-014516-r59usk02 162 18 . . . cord-014516-r59usk02 163 1 20 20 CD cord-014516-r59usk02 163 2 out out IN cord-014516-r59usk02 163 3 of of IN cord-014516-r59usk02 163 4 the the DT cord-014516-r59usk02 163 5 30 30 CD cord-014516-r59usk02 163 6 dogs dog NNS cord-014516-r59usk02 163 7 ( ( -LRB- cord-014516-r59usk02 163 8 67 67 CD cord-014516-r59usk02 163 9 % % NN cord-014516-r59usk02 163 10 ) ) -RRB- cord-014516-r59usk02 163 11 had have VBD cord-014516-r59usk02 163 12 concordant concordant JJ cord-014516-r59usk02 163 13 results result NNS cord-014516-r59usk02 163 14 for for IN cord-014516-r59usk02 163 15 S100A12 s100a12 NN cord-014516-r59usk02 163 16 and and CC cord-014516-r59usk02 163 17 calprotectin calprotectin NN cord-014516-r59usk02 163 18 tests test NNS cord-014516-r59usk02 163 19 . . . cord-014516-r59usk02 164 1 Among among IN cord-014516-r59usk02 164 2 these these DT cord-014516-r59usk02 164 3 20 20 CD cord-014516-r59usk02 164 4 dogs dog NNS cord-014516-r59usk02 164 5 , , , cord-014516-r59usk02 164 6 11 11 CD cord-014516-r59usk02 164 7 presented present VBD cord-014516-r59usk02 164 8 with with IN cord-014516-r59usk02 164 9 a a DT cord-014516-r59usk02 164 10 CCECAI CCECAI NNP cord-014516-r59usk02 164 11 < < XX cord-014516-r59usk02 164 12 12 12 CD cord-014516-r59usk02 164 13 and and CC cord-014516-r59usk02 164 14 8 8 CD cord-014516-r59usk02 164 15 of of IN cord-014516-r59usk02 164 16 these these DT cord-014516-r59usk02 164 17 11 11 CD cord-014516-r59usk02 164 18 dogs dog NNS cord-014516-r59usk02 164 19 had have VBD cord-014516-r59usk02 164 20 both both DT cord-014516-r59usk02 164 21 markers marker NNS cord-014516-r59usk02 164 22 below below IN cord-014516-r59usk02 164 23 their -PRON- PRP$ cord-014516-r59usk02 164 24 cut cut VB cord-014516-r59usk02 164 25 - - HYPH cord-014516-r59usk02 164 26 off off RP cord-014516-r59usk02 164 27 values value NNS cord-014516-r59usk02 164 28 . . . cord-014516-r59usk02 165 1 Among among IN cord-014516-r59usk02 165 2 the the DT cord-014516-r59usk02 165 3 9 9 CD cord-014516-r59usk02 165 4 dogs dog NNS cord-014516-r59usk02 165 5 with with IN cord-014516-r59usk02 165 6 a a DT cord-014516-r59usk02 165 7 CCECAI≥12 ccecai≥12 NN cord-014516-r59usk02 165 8 , , , cord-014516-r59usk02 165 9 8 8 CD cord-014516-r59usk02 165 10 dogs dog NNS cord-014516-r59usk02 165 11 had have VBD cord-014516-r59usk02 165 12 both both DT cord-014516-r59usk02 165 13 markers marker NNS cord-014516-r59usk02 165 14 above above IN cord-014516-r59usk02 165 15 their -PRON- PRP$ cord-014516-r59usk02 165 16 cutoff cutoff NN cord-014516-r59usk02 165 17 values value NNS cord-014516-r59usk02 165 18 . . . cord-014516-r59usk02 166 1 66 66 CD cord-014516-r59usk02 166 2 % % NN cord-014516-r59usk02 166 3 of of IN cord-014516-r59usk02 166 4 dogs dog NNS cord-014516-r59usk02 166 5 ( ( -LRB- cord-014516-r59usk02 166 6 19/29 19/29 CD cord-014516-r59usk02 166 7 ) ) -RRB- cord-014516-r59usk02 166 8 presented present VBD cord-014516-r59usk02 166 9 histologic histologic JJ cord-014516-r59usk02 166 10 signs sign NNS cord-014516-r59usk02 166 11 of of IN cord-014516-r59usk02 166 12 inflammation inflammation NN cord-014516-r59usk02 166 13 . . . cord-014516-r59usk02 167 1 Sensitivities sensitivity NNS cord-014516-r59usk02 167 2 for for IN cord-014516-r59usk02 167 3 fecal fecal JJ cord-014516-r59usk02 167 4 calprotectin calprotectin NNS cord-014516-r59usk02 167 5 and and CC cord-014516-r59usk02 167 6 S100A12 s100a12 NN cord-014516-r59usk02 167 7 concentrations concentration NNS cord-014516-r59usk02 167 8 for for IN cord-014516-r59usk02 167 9 histopathological histopathological JJ cord-014516-r59usk02 167 10 intestinal intestinal JJ cord-014516-r59usk02 167 11 inflammation inflammation NN cord-014516-r59usk02 167 12 were be VBD cord-014516-r59usk02 167 13 42 42 CD cord-014516-r59usk02 167 14 % % NN cord-014516-r59usk02 167 15 and and CC cord-014516-r59usk02 167 16 68 68 CD cord-014516-r59usk02 167 17 % % NN cord-014516-r59usk02 167 18 , , , cord-014516-r59usk02 167 19 respectively respectively RB cord-014516-r59usk02 167 20 , , , cord-014516-r59usk02 167 21 and and CC cord-014516-r59usk02 167 22 specificities specificity NNS cord-014516-r59usk02 167 23 were be VBD cord-014516-r59usk02 167 24 80 80 CD cord-014516-r59usk02 167 25 % % NN cord-014516-r59usk02 167 26 and and CC cord-014516-r59usk02 167 27 30 30 CD cord-014516-r59usk02 167 28 % % NN cord-014516-r59usk02 167 29 , , , cord-014516-r59usk02 167 30 respectively respectively RB cord-014516-r59usk02 167 31 . . . cord-014516-r59usk02 168 1 At at IN cord-014516-r59usk02 168 2 least least JJS cord-014516-r59usk02 168 3 in in IN cord-014516-r59usk02 168 4 this this DT cord-014516-r59usk02 168 5 group group NN cord-014516-r59usk02 168 6 of of IN cord-014516-r59usk02 168 7 patients patient NNS cord-014516-r59usk02 168 8 fecal fecal JJ cord-014516-r59usk02 168 9 S100A12 s100a12 NN cord-014516-r59usk02 168 10 concentration concentration NN cord-014516-r59usk02 168 11 was be VBD cord-014516-r59usk02 168 12 more more RBR cord-014516-r59usk02 168 13 sensitive sensitive JJ cord-014516-r59usk02 168 14 ( ( -LRB- cord-014516-r59usk02 168 15 but but CC cord-014516-r59usk02 168 16 less less RBR cord-014516-r59usk02 168 17 specific specific JJ cord-014516-r59usk02 168 18 ) ) -RRB- cord-014516-r59usk02 168 19 to to TO cord-014516-r59usk02 168 20 detect detect VB cord-014516-r59usk02 168 21 dogs dog NNS cord-014516-r59usk02 168 22 with with IN cord-014516-r59usk02 168 23 a a DT cord-014516-r59usk02 168 24 CCE CCE NNP cord-014516-r59usk02 168 25 - - HYPH cord-014516-r59usk02 168 26 CAI CAI NNP cord-014516-r59usk02 169 1 ≥ ≥ CD cord-014516-r59usk02 169 2 12 12 CD cord-014516-r59usk02 169 3 or or CC cord-014516-r59usk02 169 4 histopathologic histopathologic JJ cord-014516-r59usk02 169 5 intestinal intestinal JJ cord-014516-r59usk02 169 6 inflammation inflammation NN cord-014516-r59usk02 169 7 than than IN cord-014516-r59usk02 169 8 fecal fecal JJ cord-014516-r59usk02 169 9 calprotectin calprotectin NN cord-014516-r59usk02 169 10 concentration concentration NN cord-014516-r59usk02 169 11 . . . cord-014516-r59usk02 170 1 Weight weight NN cord-014516-r59usk02 170 2 loss loss NN cord-014516-r59usk02 170 3 and and CC cord-014516-r59usk02 170 4 malabsorption malabsorption NN cord-014516-r59usk02 170 5 of of IN cord-014516-r59usk02 170 6 fat fat NN cord-014516-r59usk02 170 7 , , , cord-014516-r59usk02 170 8 protein protein NN cord-014516-r59usk02 170 9 , , , cord-014516-r59usk02 170 10 cobalamin cobalamin NN cord-014516-r59usk02 170 11 and and CC cord-014516-r59usk02 170 12 tocopherol tocopherol NN cord-014516-r59usk02 170 13 in in IN cord-014516-r59usk02 170 14 the the DT cord-014516-r59usk02 170 15 face face NN cord-014516-r59usk02 170 16 of of IN cord-014516-r59usk02 170 17 normal normal JJ cord-014516-r59usk02 170 18 exocrine exocrine JJ cord-014516-r59usk02 170 19 pancreatic pancreatic NN cord-014516-r59usk02 170 20 function function NN cord-014516-r59usk02 170 21 have have VBP cord-014516-r59usk02 170 22 been be VBN cord-014516-r59usk02 170 23 reported report VBN cord-014516-r59usk02 170 24 in in IN cord-014516-r59usk02 170 25 up up IN cord-014516-r59usk02 170 26 to to TO cord-014516-r59usk02 170 27 30 30 CD cord-014516-r59usk02 170 28 - - SYM cord-014516-r59usk02 170 29 40 40 CD cord-014516-r59usk02 170 30 % % NN cord-014516-r59usk02 170 31 of of IN cord-014516-r59usk02 170 32 cats cat NNS cord-014516-r59usk02 170 33 older old JJR cord-014516-r59usk02 170 34 than than IN cord-014516-r59usk02 170 35 12 12 CD cord-014516-r59usk02 170 36 years year NNS cord-014516-r59usk02 170 37 of of IN cord-014516-r59usk02 170 38 age age NN cord-014516-r59usk02 170 39 fed feed VBD cord-014516-r59usk02 170 40 a a DT cord-014516-r59usk02 170 41 variety variety NN cord-014516-r59usk02 170 42 of of IN cord-014516-r59usk02 170 43 nutritionally nutritionally RB cord-014516-r59usk02 170 44 balanced balanced JJ cord-014516-r59usk02 170 45 dry dry JJ cord-014516-r59usk02 170 46 and and CC cord-014516-r59usk02 170 47 wet wet JJ cord-014516-r59usk02 170 48 foods food NNS cord-014516-r59usk02 170 49 ( ( -LRB- cord-014516-r59usk02 170 50 Patil Patil NNP cord-014516-r59usk02 170 51 AP AP NNP cord-014516-r59usk02 170 52 and and CC cord-014516-r59usk02 170 53 Cupp Cupp NNP cord-014516-r59usk02 170 54 CJ CJ NNP cord-014516-r59usk02 170 55 . . . cord-014516-r59usk02 171 1 Proc proc VB cord-014516-r59usk02 171 2 . . . cord-014516-r59usk02 172 1 Nestle Nestle NNP cord-014516-r59usk02 172 2 - - HYPH cord-014516-r59usk02 172 3 Purina Purina NNP cord-014516-r59usk02 172 4 Compan Compan NNP cord-014516-r59usk02 172 5 Anim Anim NNP cord-014516-r59usk02 172 6 Nutr Nutr NNP cord-014516-r59usk02 172 7 Summit Summit NNP cord-014516-r59usk02 172 8 , , , cord-014516-r59usk02 172 9 Focus Focus NNP cord-014516-r59usk02 172 10 on on IN cord-014516-r59usk02 172 11 Gastroenterology Gastroenterology NNP cord-014516-r59usk02 172 12 , , , cord-014516-r59usk02 172 13 [ [ -LRB- cord-014516-r59usk02 172 14 55 55 CD cord-014516-r59usk02 172 15 ] ] -RRB- cord-014516-r59usk02 172 16 [ [ -LRB- cord-014516-r59usk02 172 17 56 56 CD cord-014516-r59usk02 172 18 ] ] -RRB- cord-014516-r59usk02 172 19 [ [ -LRB- cord-014516-r59usk02 172 20 57 57 CD cord-014516-r59usk02 172 21 ] ] -RRB- cord-014516-r59usk02 172 22 [ [ -LRB- cord-014516-r59usk02 172 23 58 58 CD cord-014516-r59usk02 172 24 ] ] -RRB- cord-014516-r59usk02 172 25 [ [ -LRB- cord-014516-r59usk02 172 26 59 59 CD cord-014516-r59usk02 172 27 ] ] -RRB- cord-014516-r59usk02 172 28 [ [ -LRB- cord-014516-r59usk02 172 29 60 60 CD cord-014516-r59usk02 172 30 ] ] -RRB- cord-014516-r59usk02 172 31 [ [ -LRB- cord-014516-r59usk02 172 32 61 61 CD cord-014516-r59usk02 172 33 ] ] -RRB- cord-014516-r59usk02 172 34 2010 2010 CD cord-014516-r59usk02 172 35 ) ) -RRB- cord-014516-r59usk02 172 36 . . . cord-014516-r59usk02 173 1 The the DT cord-014516-r59usk02 173 2 objectives objective NNS cord-014516-r59usk02 173 3 of of IN cord-014516-r59usk02 173 4 this this DT cord-014516-r59usk02 173 5 study study NN cord-014516-r59usk02 173 6 were be VBD cord-014516-r59usk02 173 7 to to TO cord-014516-r59usk02 173 8 determine determine VB cord-014516-r59usk02 173 9 if if IN cord-014516-r59usk02 173 10 serum serum NN cord-014516-r59usk02 173 11 cobalamin cobalamin NN cord-014516-r59usk02 173 12 concentrations concentration NNS cord-014516-r59usk02 173 13 increased increase VBD cord-014516-r59usk02 173 14 after after IN cord-014516-r59usk02 173 15 oral oral JJ cord-014516-r59usk02 173 16 administration administration NN cord-014516-r59usk02 173 17 of of IN cord-014516-r59usk02 173 18 a a DT cord-014516-r59usk02 173 19 cobalamin cobalamin NN cord-014516-r59usk02 173 20 supplement supplement NN cord-014516-r59usk02 173 21 to to IN cord-014516-r59usk02 173 22 affected affected JJ cord-014516-r59usk02 173 23 cats cat NNS cord-014516-r59usk02 173 24 , , , cord-014516-r59usk02 173 25 and and CC cord-014516-r59usk02 173 26 the the DT cord-014516-r59usk02 173 27 duration duration NN cord-014516-r59usk02 173 28 of of IN cord-014516-r59usk02 173 29 any any DT cord-014516-r59usk02 173 30 positive positive JJ cord-014516-r59usk02 173 31 response response NN cord-014516-r59usk02 173 32 following follow VBG cord-014516-r59usk02 173 33 cessation cessation NN cord-014516-r59usk02 173 34 of of IN cord-014516-r59usk02 173 35 supplementation supplementation NN cord-014516-r59usk02 173 36 . . . cord-014516-r59usk02 174 1 The the DT cord-014516-r59usk02 174 2 study study NN cord-014516-r59usk02 174 3 evaluated evaluate VBD cord-014516-r59usk02 174 4 14 14 CD cord-014516-r59usk02 174 5 cats cat NNS cord-014516-r59usk02 174 6 older old JJR cord-014516-r59usk02 174 7 than than IN cord-014516-r59usk02 174 8 12 12 CD cord-014516-r59usk02 174 9 years year NNS cord-014516-r59usk02 174 10 of of IN cord-014516-r59usk02 174 11 age age NN cord-014516-r59usk02 174 12 with with IN cord-014516-r59usk02 174 13 fat fat JJ cord-014516-r59usk02 174 14 malabsorption malabsorption NN cord-014516-r59usk02 174 15 demonstrated demonstrate VBN cord-014516-r59usk02 174 16 by by IN cord-014516-r59usk02 174 17 either either CC cord-014516-r59usk02 174 18 increased increase VBN cord-014516-r59usk02 174 19 fecal fecal JJ cord-014516-r59usk02 174 20 fat fat NN cord-014516-r59usk02 174 21 ( ( -LRB- cord-014516-r59usk02 174 22 > > NFP cord-014516-r59usk02 174 23 20 20 CD cord-014516-r59usk02 174 24 % % NN cord-014516-r59usk02 174 25 ) ) -RRB- cord-014516-r59usk02 174 26 or or CC cord-014516-r59usk02 174 27 subnormal subnormal JJ cord-014516-r59usk02 174 28 fat fat JJ cord-014516-r59usk02 174 29 digestibility digestibility NN cord-014516-r59usk02 174 30 ( ( -LRB- cord-014516-r59usk02 174 31 < < XX cord-014516-r59usk02 174 32 80 80 CD cord-014516-r59usk02 174 33 % % NN cord-014516-r59usk02 174 34 ) ) -RRB- cord-014516-r59usk02 174 35 , , , cord-014516-r59usk02 174 36 but but CC cord-014516-r59usk02 174 37 without without IN cord-014516-r59usk02 174 38 exocrine exocrine JJ cord-014516-r59usk02 174 39 pancreatic pancreatic JJ cord-014516-r59usk02 174 40 insufficiency insufficiency NN cord-014516-r59usk02 174 41 ( ( -LRB- cord-014516-r59usk02 174 42 EPI EPI NNP cord-014516-r59usk02 174 43 ) ) -RRB- cord-014516-r59usk02 174 44 as as IN cord-014516-r59usk02 174 45 assessed assess VBN cord-014516-r59usk02 174 46 by by IN cord-014516-r59usk02 174 47 assay assay NN cord-014516-r59usk02 174 48 of of IN cord-014516-r59usk02 174 49 serum serum NN cord-014516-r59usk02 174 50 trypsin trypsin NN cord-014516-r59usk02 174 51 - - HYPH cord-014516-r59usk02 174 52 like like JJ cord-014516-r59usk02 174 53 immunoreactivity immunoreactivity NN cord-014516-r59usk02 174 54 ( ( -LRB- cord-014516-r59usk02 174 55 fTLI ftli NN cord-014516-r59usk02 174 56 ) ) -RRB- cord-014516-r59usk02 174 57 . . . cord-014516-r59usk02 175 1 A a DT cord-014516-r59usk02 175 2 commercially commercially RB cord-014516-r59usk02 175 3 available available JJ cord-014516-r59usk02 175 4 solution solution NN cord-014516-r59usk02 175 5 of of IN cord-014516-r59usk02 175 6 cobalamin cobalamin NN cord-014516-r59usk02 175 7 containing contain VBG cord-014516-r59usk02 175 8 1 1 CD cord-014516-r59usk02 175 9 mg mg NNS cord-014516-r59usk02 175 10 mixed mix VBN cord-014516-r59usk02 175 11 with with IN cord-014516-r59usk02 175 12 1 1 CD cord-014516-r59usk02 175 13 mL ml NN cord-014516-r59usk02 175 14 of of IN cord-014516-r59usk02 175 15 a a DT cord-014516-r59usk02 175 16 liquid liquid JJ cord-014516-r59usk02 175 17 flavor flavor NN cord-014516-r59usk02 175 18 enhancer enhancer NN cord-014516-r59usk02 175 19 was be VBD cord-014516-r59usk02 175 20 added add VBN cord-014516-r59usk02 175 21 to to IN cord-014516-r59usk02 175 22 the the DT cord-014516-r59usk02 175 23 food food NN cord-014516-r59usk02 175 24 of of IN cord-014516-r59usk02 175 25 each each DT cord-014516-r59usk02 175 26 cat cat NN cord-014516-r59usk02 175 27 in in IN cord-014516-r59usk02 175 28 a a DT cord-014516-r59usk02 175 29 single single JJ cord-014516-r59usk02 175 30 dose dose NN cord-014516-r59usk02 175 31 each each DT cord-014516-r59usk02 175 32 day day NN cord-014516-r59usk02 175 33 for for IN cord-014516-r59usk02 175 34 2 2 CD cord-014516-r59usk02 175 35 months month NNS cord-014516-r59usk02 175 36 , , , cord-014516-r59usk02 175 37 after after IN cord-014516-r59usk02 175 38 which which WDT cord-014516-r59usk02 175 39 supplementation supplementation NN cord-014516-r59usk02 175 40 ceased cease VBD cord-014516-r59usk02 175 41 . . . cord-014516-r59usk02 176 1 Serum serum NN cord-014516-r59usk02 176 2 cobalamin cobalamin NN cord-014516-r59usk02 176 3 ( ( -LRB- cord-014516-r59usk02 176 4 assayed assay VBN cord-014516-r59usk02 176 5 by by IN cord-014516-r59usk02 176 6 competitive competitive JJ cord-014516-r59usk02 176 7 binding binding NN cord-014516-r59usk02 176 8 assay assay NN cord-014516-r59usk02 176 9 performed perform VBN cord-014516-r59usk02 176 10 through through IN cord-014516-r59usk02 176 11 the the DT cord-014516-r59usk02 176 12 GI GI NNP cord-014516-r59usk02 176 13 Laboratory Laboratory NNP cord-014516-r59usk02 176 14 at at IN cord-014516-r59usk02 176 15 Texas Texas NNP cord-014516-r59usk02 176 16 A&M A&M NNP cord-014516-r59usk02 176 17 University University NNP cord-014516-r59usk02 176 18 and and CC cord-014516-r59usk02 176 19 evaluated evaluate VBD cord-014516-r59usk02 176 20 using use VBG cord-014516-r59usk02 176 21 reference reference NN cord-014516-r59usk02 176 22 ranges range NNS cord-014516-r59usk02 176 23 derived derive VBN cord-014516-r59usk02 176 24 by by IN cord-014516-r59usk02 176 25 that that DT cord-014516-r59usk02 176 26 laboratory laboratory NN cord-014516-r59usk02 176 27 ) ) -RRB- cord-014516-r59usk02 176 28 was be VBD cord-014516-r59usk02 176 29 determined determine VBN cord-014516-r59usk02 176 30 immediately immediately RB cord-014516-r59usk02 176 31 prior prior RB cord-014516-r59usk02 176 32 to to IN cord-014516-r59usk02 176 33 initiation initiation NN cord-014516-r59usk02 176 34 of of IN cord-014516-r59usk02 176 35 supplementation supplementation NN cord-014516-r59usk02 176 36 , , , cord-014516-r59usk02 176 37 then then RB cord-014516-r59usk02 176 38 weekly weekly VB cord-014516-r59usk02 176 39 for for IN cord-014516-r59usk02 176 40 3 3 CD cord-014516-r59usk02 176 41 weeks week NNS cord-014516-r59usk02 176 42 , , , cord-014516-r59usk02 176 43 then then RB cord-014516-r59usk02 176 44 monthly monthly VB cord-014516-r59usk02 176 45 for for IN cord-014516-r59usk02 176 46 4 4 CD cord-014516-r59usk02 176 47 months month NNS cord-014516-r59usk02 176 48 . . . cord-014516-r59usk02 177 1 At at IN cord-014516-r59usk02 177 2 the the DT cord-014516-r59usk02 177 3 start start NN cord-014516-r59usk02 177 4 of of IN cord-014516-r59usk02 177 5 the the DT cord-014516-r59usk02 177 6 study study NN cord-014516-r59usk02 177 7 serum serum NN cord-014516-r59usk02 177 8 cobalamin cobalamin NN cord-014516-r59usk02 177 9 was be VBD cord-014516-r59usk02 177 10 subnormal subnormal JJ cord-014516-r59usk02 177 11 ( ( -LRB- cord-014516-r59usk02 177 12 < < XX cord-014516-r59usk02 177 13 290 290 CD cord-014516-r59usk02 177 14 ng ng NNP cord-014516-r59usk02 177 15 / / SYM cord-014516-r59usk02 177 16 L L NNP cord-014516-r59usk02 177 17 ) ) -RRB- cord-014516-r59usk02 177 18 in in IN cord-014516-r59usk02 177 19 4 4 CD cord-014516-r59usk02 177 20 of of IN cord-014516-r59usk02 177 21 the the DT cord-014516-r59usk02 177 22 14 14 CD cord-014516-r59usk02 177 23 cats cat NNS cord-014516-r59usk02 177 24 ( ( -LRB- cord-014516-r59usk02 177 25 range range VB cord-014516-r59usk02 177 26 < < XX cord-014516-r59usk02 177 27 150 150 CD cord-014516-r59usk02 177 28 to to IN cord-014516-r59usk02 177 29 244 244 CD cord-014516-r59usk02 177 30 ng ng NN cord-014516-r59usk02 177 31 / / SYM cord-014516-r59usk02 177 32 L L NNP cord-014516-r59usk02 177 33 ) ) -RRB- cord-014516-r59usk02 177 34 and and CC cord-014516-r59usk02 177 35 within within IN cord-014516-r59usk02 177 36 the the DT cord-014516-r59usk02 177 37 reference reference NN cord-014516-r59usk02 177 38 range range NN cord-014516-r59usk02 177 39 ( ( -LRB- cord-014516-r59usk02 177 40 290 290 CD cord-014516-r59usk02 177 41 to to TO cord-014516-r59usk02 177 42 1499 1499 CD cord-014516-r59usk02 177 43 ng ng NNP cord-014516-r59usk02 177 44 / / SYM cord-014516-r59usk02 177 45 L L NNP cord-014516-r59usk02 177 46 ) ) -RRB- cord-014516-r59usk02 177 47 in in IN cord-014516-r59usk02 177 48 the the DT cord-014516-r59usk02 177 49 remaining remain VBG cord-014516-r59usk02 177 50 10 10 CD cord-014516-r59usk02 177 51 cats cat NNS cord-014516-r59usk02 177 52 ( ( -LRB- cord-014516-r59usk02 177 53 334 334 CD cord-014516-r59usk02 177 54 to to IN cord-014516-r59usk02 177 55 1065 1065 CD cord-014516-r59usk02 177 56 ng ng NNP cord-014516-r59usk02 177 57 / / SYM cord-014516-r59usk02 177 58 L L NNP cord-014516-r59usk02 177 59 ) ) -RRB- cord-014516-r59usk02 177 60 . . . cord-014516-r59usk02 178 1 Serum serum NN cord-014516-r59usk02 178 2 cobalamin cobalamin NN cord-014516-r59usk02 178 3 was be VBD cord-014516-r59usk02 178 4 above above IN cord-014516-r59usk02 178 5 the the DT cord-014516-r59usk02 178 6 reference reference NN cord-014516-r59usk02 178 7 range range NN cord-014516-r59usk02 178 8 in in IN cord-014516-r59usk02 178 9 every every DT cord-014516-r59usk02 178 10 cat cat NN cord-014516-r59usk02 178 11 ( ( -LRB- cord-014516-r59usk02 178 12 1892 1892 CD cord-014516-r59usk02 178 13 to to IN cord-014516-r59usk02 178 14 13109 13109 CD cord-014516-r59usk02 178 15 ng ng NNP cord-014516-r59usk02 178 16 / / SYM cord-014516-r59usk02 178 17 L L NNP cord-014516-r59usk02 178 18 ) ) -RRB- cord-014516-r59usk02 178 19 after after IN cord-014516-r59usk02 178 20 one one CD cord-014516-r59usk02 178 21 week week NN cord-014516-r59usk02 178 22 of of IN cord-014516-r59usk02 178 23 supplementation supplementation NN cord-014516-r59usk02 178 24 and and CC cord-014516-r59usk02 178 25 remained remain VBD cord-014516-r59usk02 178 26 above above IN cord-014516-r59usk02 178 27 the the DT cord-014516-r59usk02 178 28 reference reference NN cord-014516-r59usk02 178 29 range range NN cord-014516-r59usk02 178 30 in in IN cord-014516-r59usk02 178 31 every every DT cord-014516-r59usk02 178 32 sample sample NN cord-014516-r59usk02 178 33 collected collect VBN cord-014516-r59usk02 178 34 during during IN cord-014516-r59usk02 178 35 the the DT cord-014516-r59usk02 178 36 supplementation supplementation NN cord-014516-r59usk02 178 37 period period NN cord-014516-r59usk02 178 38 , , , cord-014516-r59usk02 178 39 with with IN cord-014516-r59usk02 178 40 the the DT cord-014516-r59usk02 178 41 exception exception NN cord-014516-r59usk02 178 42 of of IN cord-014516-r59usk02 178 43 two two CD cord-014516-r59usk02 178 44 cats cat NNS cord-014516-r59usk02 178 45 with with IN cord-014516-r59usk02 178 46 values value NNS cord-014516-r59usk02 178 47 within within IN cord-014516-r59usk02 178 48 the the DT cord-014516-r59usk02 178 49 reference reference NN cord-014516-r59usk02 178 50 range range NN cord-014516-r59usk02 178 51 when when WRB cord-014516-r59usk02 178 52 supplementation supplementation NN cord-014516-r59usk02 178 53 was be VBD cord-014516-r59usk02 178 54 stopped stop VBN cord-014516-r59usk02 178 55 . . . cord-014516-r59usk02 179 1 Serum serum NN cord-014516-r59usk02 179 2 cobalamin cobalamin NN cord-014516-r59usk02 179 3 1 1 CD cord-014516-r59usk02 179 4 , , , cord-014516-r59usk02 179 5 2 2 CD cord-014516-r59usk02 179 6 and and CC cord-014516-r59usk02 179 7 3 3 CD cord-014516-r59usk02 179 8 months month NNS cord-014516-r59usk02 180 1 after after IN cord-014516-r59usk02 180 2 cessation cessation NN cord-014516-r59usk02 180 3 of of IN cord-014516-r59usk02 180 4 supplementation supplementation NN cord-014516-r59usk02 180 5 ranged range VBN cord-014516-r59usk02 180 6 from from IN cord-014516-r59usk02 180 7 < < XX cord-014516-r59usk02 180 8 150 150 CD cord-014516-r59usk02 180 9 to to IN cord-014516-r59usk02 180 10 1783 1783 CD cord-014516-r59usk02 180 11 , , , cord-014516-r59usk02 180 12 < < XX cord-014516-r59usk02 180 13 150 150 CD cord-014516-r59usk02 180 14 to to IN cord-014516-r59usk02 180 15 1494 1494 CD cord-014516-r59usk02 180 16 , , , cord-014516-r59usk02 180 17 and and CC cord-014516-r59usk02 180 18 < < XX cord-014516-r59usk02 180 19 150 150 CD cord-014516-r59usk02 180 20 to to TO cord-014516-r59usk02 180 21 948 948 CD cord-014516-r59usk02 180 22 ng ng NN cord-014516-r59usk02 180 23 / / SYM cord-014516-r59usk02 180 24 L L NNP cord-014516-r59usk02 180 25 , , , cord-014516-r59usk02 180 26 respectively respectively RB cord-014516-r59usk02 180 27 . . . cord-014516-r59usk02 181 1 At at IN cord-014516-r59usk02 181 2 the the DT cord-014516-r59usk02 181 3 end end NN cord-014516-r59usk02 181 4 of of IN cord-014516-r59usk02 181 5 the the DT cord-014516-r59usk02 181 6 study study NN cord-014516-r59usk02 181 7 serum serum NN cord-014516-r59usk02 181 8 cobalamin cobalamin NN cord-014516-r59usk02 181 9 was be VBD cord-014516-r59usk02 181 10 subnormal subnormal JJ cord-014516-r59usk02 181 11 in in IN cord-014516-r59usk02 181 12 5 5 CD cord-014516-r59usk02 181 13 of of IN cord-014516-r59usk02 181 14 the the DT cord-014516-r59usk02 181 15 14 14 CD cord-014516-r59usk02 181 16 cats cat NNS cord-014516-r59usk02 181 17 . . . cord-014516-r59usk02 182 1 It -PRON- PRP cord-014516-r59usk02 182 2 is be VBZ cord-014516-r59usk02 182 3 concluded conclude VBN cord-014516-r59usk02 182 4 oral oral JJ cord-014516-r59usk02 182 5 cobalamin cobalamin NN cord-014516-r59usk02 182 6 supplementation supplementation NN cord-014516-r59usk02 182 7 can can MD cord-014516-r59usk02 182 8 effectively effectively RB cord-014516-r59usk02 182 9 increase increase VB cord-014516-r59usk02 182 10 serum serum NN cord-014516-r59usk02 182 11 cobalamin cobalamin NN cord-014516-r59usk02 182 12 concentrations concentration NNS cord-014516-r59usk02 182 13 in in IN cord-014516-r59usk02 182 14 geriatric geriatric JJ cord-014516-r59usk02 182 15 cats cat NNS cord-014516-r59usk02 182 16 with with IN cord-014516-r59usk02 182 17 idiopathic idiopathic JJ cord-014516-r59usk02 182 18 chronic chronic JJ cord-014516-r59usk02 182 19 enteropathy enteropathy NN cord-014516-r59usk02 182 20 , , , cord-014516-r59usk02 182 21 but but CC cord-014516-r59usk02 182 22 that that IN cord-014516-r59usk02 182 23 following follow VBG cord-014516-r59usk02 182 24 cessation cessation NN cord-014516-r59usk02 182 25 of of IN cord-014516-r59usk02 182 26 supplementation supplementation NN cord-014516-r59usk02 182 27 concentrations concentration NNS cord-014516-r59usk02 182 28 decrease decrease VBP cord-014516-r59usk02 182 29 rapidly rapidly RB cord-014516-r59usk02 182 30 and and CC cord-014516-r59usk02 182 31 can can MD cord-014516-r59usk02 182 32 become become VB cord-014516-r59usk02 182 33 subnormal subnormal JJ cord-014516-r59usk02 182 34 again again RB cord-014516-r59usk02 182 35 within within IN cord-014516-r59usk02 182 36 as as RB cord-014516-r59usk02 182 37 few few JJ cord-014516-r59usk02 182 38 as as IN cord-014516-r59usk02 182 39 4 4 CD cord-014516-r59usk02 182 40 weeks week NNS cord-014516-r59usk02 182 41 . . . cord-014516-r59usk02 183 1 The the DT cord-014516-r59usk02 183 2 primary primary JJ cord-014516-r59usk02 183 3 author author NN cord-014516-r59usk02 183 4 collaborated collaborate VBD cord-014516-r59usk02 183 5 with with IN cord-014516-r59usk02 183 6 Nestle Nestle NNP cord-014516-r59usk02 183 7 - - HYPH cord-014516-r59usk02 183 8 Purinaon Purinaon NNP cord-014516-r59usk02 183 9 the the DT cord-014516-r59usk02 183 10 work work NN cord-014516-r59usk02 183 11 reported report VBN cord-014516-r59usk02 183 12 in in IN cord-014516-r59usk02 183 13 this this DT cord-014516-r59usk02 183 14 abstract abstract NN cord-014516-r59usk02 183 15 , , , cord-014516-r59usk02 183 16 and and CC cord-014516-r59usk02 183 17 a a DT cord-014516-r59usk02 183 18 co co NN cord-014516-r59usk02 183 19 - - NN cord-014516-r59usk02 183 20 authoris authoris JJ cord-014516-r59usk02 183 21 an an DT cord-014516-r59usk02 183 22 employee employee NN cord-014516-r59usk02 183 23 of of IN cord-014516-r59usk02 183 24 Nestle Nestle NNP cord-014516-r59usk02 183 25 - - HYPH cord-014516-r59usk02 183 26 Purina Purina NNP cord-014516-r59usk02 183 27 . . . cord-014516-r59usk02 184 1 The the DT cord-014516-r59usk02 184 2 primary primary JJ cord-014516-r59usk02 184 3 author author NN cord-014516-r59usk02 184 4 has have VBZ cord-014516-r59usk02 184 5 previously previously RB cord-014516-r59usk02 184 6 received receive VBN cord-014516-r59usk02 184 7 funding funding NN cord-014516-r59usk02 184 8 from from IN cord-014516-r59usk02 184 9 Iams Iams NNP cord-014516-r59usk02 184 10 , , , cord-014516-r59usk02 184 11 Mars Mars NNP cord-014516-r59usk02 184 12 , , , cord-014516-r59usk02 184 13 Hills Hills NNP cord-014516-r59usk02 184 14 and and CC cord-014516-r59usk02 184 15 Nestle Nestle NNP cord-014516-r59usk02 184 16 - - HYPH cord-014516-r59usk02 184 17 Purina Purina NNP cord-014516-r59usk02 184 18 . . . cord-014516-r59usk02 185 1 The the DT cord-014516-r59usk02 185 2 author author NN cord-014516-r59usk02 185 3 also also RB cord-014516-r59usk02 185 4 acts act VBZ cord-014516-r59usk02 185 5 as as IN cord-014516-r59usk02 185 6 a a DT cord-014516-r59usk02 185 7 paid pay VBN cord-014516-r59usk02 185 8 consultant consultant NN cord-014516-r59usk02 185 9 for for IN cord-014516-r59usk02 185 10 the the DT cord-014516-r59usk02 185 11 GI GI NNP cord-014516-r59usk02 185 12 - - HYPH cord-014516-r59usk02 185 13 Lab Lab NNP cord-014516-r59usk02 185 14 , , , cord-014516-r59usk02 185 15 Texas Texas NNP cord-014516-r59usk02 185 16 A&M A&M NNP cord-014516-r59usk02 185 17 University University NNP cord-014516-r59usk02 185 18 . . . cord-014516-r59usk02 186 1 Left leave VBN cord-014516-r59usk02 186 2 atrial atrial JJ cord-014516-r59usk02 186 3 measurements measurement NNS cord-014516-r59usk02 186 4 are be VBP cord-014516-r59usk02 186 5 crucial crucial JJ cord-014516-r59usk02 186 6 in in IN cord-014516-r59usk02 186 7 assessing assess VBG cord-014516-r59usk02 186 8 severity severity NN cord-014516-r59usk02 186 9 of of IN cord-014516-r59usk02 186 10 cardiac cardiac JJ cord-014516-r59usk02 186 11 disease disease NN cord-014516-r59usk02 186 12 in in IN cord-014516-r59usk02 186 13 dogs dog NNS cord-014516-r59usk02 186 14 with with IN cord-014516-r59usk02 186 15 myxomatous myxomatous JJ cord-014516-r59usk02 186 16 mitral mitral JJ cord-014516-r59usk02 186 17 valve valve NN cord-014516-r59usk02 186 18 disease disease NN cord-014516-r59usk02 186 19 ( ( -LRB- cord-014516-r59usk02 186 20 MMVD MMVD NNP cord-014516-r59usk02 186 21 ) ) -RRB- cord-014516-r59usk02 186 22 . . . cord-014516-r59usk02 187 1 However however RB cord-014516-r59usk02 187 2 , , , cord-014516-r59usk02 187 3 linear linear JJ cord-014516-r59usk02 187 4 and and CC cord-014516-r59usk02 187 5 area area NN cord-014516-r59usk02 187 6 dimensions dimension NNS cord-014516-r59usk02 187 7 might may MD cord-014516-r59usk02 187 8 not not RB cord-014516-r59usk02 187 9 provide provide VB cord-014516-r59usk02 187 10 a a DT cord-014516-r59usk02 187 11 comprehensive comprehensive JJ cord-014516-r59usk02 187 12 assessment assessment NN cord-014516-r59usk02 187 13 of of IN cord-014516-r59usk02 187 14 patient patient NN cord-014516-r59usk02 187 15 status status NN cord-014516-r59usk02 187 16 , , , cord-014516-r59usk02 187 17 and and CC cord-014516-r59usk02 187 18 can can MD cord-014516-r59usk02 187 19 not not RB cord-014516-r59usk02 187 20 differentiate differentiate VB cord-014516-r59usk02 187 21 between between IN cord-014516-r59usk02 187 22 severe severe JJ cord-014516-r59usk02 187 23 subclinical subclinical JJ cord-014516-r59usk02 187 24 ( ( -LRB- cord-014516-r59usk02 187 25 B2 b2 NN cord-014516-r59usk02 187 26 ) ) -RRB- cord-014516-r59usk02 187 27 and and CC cord-014516-r59usk02 187 28 clinical clinical JJ cord-014516-r59usk02 187 29 disease disease NN cord-014516-r59usk02 187 30 ( ( -LRB- cord-014516-r59usk02 187 31 CHF CHF NNP cord-014516-r59usk02 187 32 ) ) -RRB- cord-014516-r59usk02 187 33 . . . cord-014516-r59usk02 188 1 Estimates estimate NNS cord-014516-r59usk02 188 2 of of IN cord-014516-r59usk02 188 3 left left JJ cord-014516-r59usk02 188 4 atrial atrial JJ cord-014516-r59usk02 188 5 function function NN cord-014516-r59usk02 188 6 could could MD cord-014516-r59usk02 188 7 provide provide VB cord-014516-r59usk02 188 8 additional additional JJ cord-014516-r59usk02 188 9 information information NN cord-014516-r59usk02 188 10 to to TO cord-014516-r59usk02 188 11 help help VB cord-014516-r59usk02 188 12 categorize categorize VB cord-014516-r59usk02 188 13 these these DT cord-014516-r59usk02 188 14 patients patient NNS cord-014516-r59usk02 188 15 . . . cord-014516-r59usk02 189 1 We -PRON- PRP cord-014516-r59usk02 189 2 examined examine VBD cord-014516-r59usk02 189 3 87 87 CD cord-014516-r59usk02 189 4 dogs dog NNS cord-014516-r59usk02 189 5 with with IN cord-014516-r59usk02 189 6 MMVD MMVD NNP cord-014516-r59usk02 189 7 ( ( -LRB- cord-014516-r59usk02 189 8 25 25 CD cord-014516-r59usk02 189 9 Normal normal JJ cord-014516-r59usk02 189 10 , , , cord-014516-r59usk02 189 11 9 9 CD cord-014516-r59usk02 189 12 B1 b1 NN cord-014516-r59usk02 189 13 , , , cord-014516-r59usk02 189 14 40 40 CD cord-014516-r59usk02 189 15 B2 b2 NN cord-014516-r59usk02 189 16 and and CC cord-014516-r59usk02 189 17 13 13 CD cord-014516-r59usk02 189 18 C C NNP cord-014516-r59usk02 189 19 ) ) -RRB- cord-014516-r59usk02 189 20 presented present VBD cord-014516-r59usk02 189 21 for for IN cord-014516-r59usk02 189 22 cardiac cardiac JJ cord-014516-r59usk02 189 23 evaluations evaluation NNS cord-014516-r59usk02 189 24 by by IN cord-014516-r59usk02 189 25 2D 2d NN cord-014516-r59usk02 189 26 echocardiography echocardiography NN cord-014516-r59usk02 189 27 . . . cord-014516-r59usk02 190 1 Left leave VBN cord-014516-r59usk02 190 2 atrial atrial JJ cord-014516-r59usk02 190 3 linear linear NN cord-014516-r59usk02 190 4 and and CC cord-014516-r59usk02 190 5 area area NN cord-014516-r59usk02 190 6 dimensions dimension NNS cord-014516-r59usk02 190 7 in in IN cord-014516-r59usk02 190 8 right right JJ cord-014516-r59usk02 190 9 parasternal parasternal JJ cord-014516-r59usk02 191 1 short short JJ cord-014516-r59usk02 191 2 and and CC cord-014516-r59usk02 191 3 long long JJ cord-014516-r59usk02 191 4 axis axis NN cord-014516-r59usk02 191 5 views view NNS cord-014516-r59usk02 191 6 were be VBD cord-014516-r59usk02 191 7 obtained obtain VBN cord-014516-r59usk02 191 8 at at IN cord-014516-r59usk02 191 9 3 3 CD cord-014516-r59usk02 191 10 time time NN cord-014516-r59usk02 191 11 points point NNS cord-014516-r59usk02 191 12 -early -early RB cord-014516-r59usk02 191 13 diastole diastole NN cord-014516-r59usk02 191 14 ( ( -LRB- cord-014516-r59usk02 191 15 LA LA NNP cord-014516-r59usk02 191 16 MAX MAX NNP cord-014516-r59usk02 191 17 ) ) -RRB- cord-014516-r59usk02 191 18 , , , cord-014516-r59usk02 191 19 just just RB cord-014516-r59usk02 191 20 prior prior RB cord-014516-r59usk02 191 21 to to IN cord-014516-r59usk02 191 22 mitral mitral JJ cord-014516-r59usk02 191 23 valve valve NN cord-014516-r59usk02 191 24 opening opening NN cord-014516-r59usk02 191 25 , , , cord-014516-r59usk02 191 26 at at IN cord-014516-r59usk02 191 27 the the DT cord-014516-r59usk02 191 28 onset onset NN cord-014516-r59usk02 191 29 of of IN cord-014516-r59usk02 191 30 atrial atrial JJ cord-014516-r59usk02 191 31 systole systole NN cord-014516-r59usk02 191 32 ( ( -LRB- cord-014516-r59usk02 191 33 LA LA NNP cord-014516-r59usk02 191 34 P P NNP cord-014516-r59usk02 191 35 ) ) -RRB- cord-014516-r59usk02 191 36 and and CC cord-014516-r59usk02 191 37 just just RB cord-014516-r59usk02 191 38 prior prior RB cord-014516-r59usk02 191 39 to to IN cord-014516-r59usk02 191 40 mitral mitral JJ cord-014516-r59usk02 191 41 valve valve NN cord-014516-r59usk02 191 42 closure closure NN cord-014516-r59usk02 191 43 ( ( -LRB- cord-014516-r59usk02 191 44 LA LA NNP cord-014516-r59usk02 191 45 MIN MIN NNP cord-014516-r59usk02 191 46 ) ) -RRB- cord-014516-r59usk02 191 47 . . . cord-014516-r59usk02 192 1 We -PRON- PRP cord-014516-r59usk02 192 2 calculated calculate VBD cord-014516-r59usk02 192 3 4 4 CD cord-014516-r59usk02 192 4 indices index NNS cord-014516-r59usk02 192 5 of of IN cord-014516-r59usk02 192 6 LA LA NNP cord-014516-r59usk02 192 7 function function NN cord-014516-r59usk02 192 8 : : : cord-014516-r59usk02 192 9 total total JJ cord-014516-r59usk02 192 10 LA LA NNP cord-014516-r59usk02 192 11 emptying empty VBG cord-014516-r59usk02 192 12 fraction fraction NN cord-014516-r59usk02 192 13 ( ( -LRB- cord-014516-r59usk02 192 14 LA LA NNP cord-014516-r59usk02 192 15 TEF TEF NNP cord-014516-r59usk02 192 16 ) ) -RRB- cord-014516-r59usk02 192 17 , , , cord-014516-r59usk02 192 18 active active JJ cord-014516-r59usk02 192 19 LA LA NNP cord-014516-r59usk02 192 20 emptying empty VBG cord-014516-r59usk02 192 21 fraction fraction NN cord-014516-r59usk02 192 22 ( ( -LRB- cord-014516-r59usk02 192 23 LA LA NNP cord-014516-r59usk02 192 24 ACT ACT NNP cord-014516-r59usk02 192 25 ) ) -RRB- cord-014516-r59usk02 192 26 , , , cord-014516-r59usk02 192 27 passive passive JJ cord-014516-r59usk02 192 28 LA LA NNP cord-014516-r59usk02 192 29 emptying empty VBG cord-014516-r59usk02 192 30 fraction fraction NN cord-014516-r59usk02 192 31 ( ( -LRB- cord-014516-r59usk02 192 32 LA LA NNP cord-014516-r59usk02 192 33 PAS PAS NNP cord-014516-r59usk02 192 34 ) ) -RRB- cord-014516-r59usk02 192 35 and and CC cord-014516-r59usk02 192 36 LA LA NNP cord-014516-r59usk02 192 37 reservoir reservoir NN cord-014516-r59usk02 192 38 function function NN cord-014516-r59usk02 192 39 ( ( -LRB- cord-014516-r59usk02 192 40 LA LA NNP cord-014516-r59usk02 192 41 RES RES NNP cord-014516-r59usk02 192 42 ) ) -RRB- cord-014516-r59usk02 192 43 for for IN cord-014516-r59usk02 192 44 all all DT cord-014516-r59usk02 192 45 4 4 CD cord-014516-r59usk02 192 46 sets set NNS cord-014516-r59usk02 192 47 of of IN cord-014516-r59usk02 192 48 measurements measurement NNS cord-014516-r59usk02 192 49 . . . cord-014516-r59usk02 193 1 We -PRON- PRP cord-014516-r59usk02 193 2 examined examine VBD cord-014516-r59usk02 193 3 the the DT cord-014516-r59usk02 193 4 differences difference NNS cord-014516-r59usk02 193 5 in in IN cord-014516-r59usk02 193 6 selected select VBN cord-014516-r59usk02 193 7 LA LA NNP cord-014516-r59usk02 193 8 function function NN cord-014516-r59usk02 193 9 indices index NNS cord-014516-r59usk02 193 10 between between IN cord-014516-r59usk02 193 11 different different JJ cord-014516-r59usk02 193 12 disease disease NN cord-014516-r59usk02 193 13 stages stage NNS cord-014516-r59usk02 193 14 with with IN cord-014516-r59usk02 193 15 a a DT cord-014516-r59usk02 193 16 Kruskal Kruskal NNP cord-014516-r59usk02 193 17 Wallis Wallis NNP cord-014516-r59usk02 193 18 Test Test NNP cord-014516-r59usk02 193 19 with with IN cord-014516-r59usk02 193 20 post post JJ cord-014516-r59usk02 193 21 - - JJ cord-014516-r59usk02 193 22 hoc hoc JJ cord-014516-r59usk02 193 23 multiple multiple JJ cord-014516-r59usk02 193 24 comparisons comparison NNS cord-014516-r59usk02 193 25 . . . cord-014516-r59usk02 194 1 We -PRON- PRP cord-014516-r59usk02 194 2 also also RB cord-014516-r59usk02 194 3 examined examine VBD cord-014516-r59usk02 194 4 the the DT cord-014516-r59usk02 194 5 diagnostic diagnostic JJ cord-014516-r59usk02 194 6 accuracy accuracy NN cord-014516-r59usk02 194 7 of of IN cord-014516-r59usk02 194 8 selected select VBN cord-014516-r59usk02 194 9 indices index NNS cord-014516-r59usk02 194 10 of of IN cord-014516-r59usk02 194 11 LA LA NNP cord-014516-r59usk02 194 12 function function NN cord-014516-r59usk02 194 13 in in IN cord-014516-r59usk02 194 14 differentiating differentiate VBG cord-014516-r59usk02 194 15 dogs dog NNS cord-014516-r59usk02 194 16 in in IN cord-014516-r59usk02 194 17 Stage stage NN cord-014516-r59usk02 194 18 B2 b2 NN cord-014516-r59usk02 194 19 and and CC cord-014516-r59usk02 194 20 Stage stage NN cord-014516-r59usk02 194 21 C C NNP cord-014516-r59usk02 195 1 ( ( -LRB- cord-014516-r59usk02 195 2 CHF CHF NNP cord-014516-r59usk02 195 3 ) ) -RRB- cord-014516-r59usk02 195 4 using use VBG cord-014516-r59usk02 195 5 ROC ROC NNP cord-014516-r59usk02 195 6 analysis analysis NN cord-014516-r59usk02 195 7 . . . cord-014516-r59usk02 196 1 Three three CD cord-014516-r59usk02 196 2 functional functional JJ cord-014516-r59usk02 196 3 indices index NNS cord-014516-r59usk02 196 4 consistently consistently RB cord-014516-r59usk02 196 5 differed differ VBD cord-014516-r59usk02 196 6 across across IN cord-014516-r59usk02 196 7 the the DT cord-014516-r59usk02 196 8 various various JJ cord-014516-r59usk02 196 9 stages stage NNS cord-014516-r59usk02 196 10 of of IN cord-014516-r59usk02 196 11 MMVD MMVD NNP cord-014516-r59usk02 196 12 -LA -LA HYPH cord-014516-r59usk02 196 13 TEF TEF NNP cord-014516-r59usk02 196 14 , , , cord-014516-r59usk02 196 15 LA LA NNP cord-014516-r59usk02 196 16 ACT ACT NNP cord-014516-r59usk02 196 17 and and CC cord-014516-r59usk02 196 18 LA LA NNP cord-014516-r59usk02 196 19 RES RES NNP cord-014516-r59usk02 196 20 . . . cord-014516-r59usk02 197 1 These these DT cord-014516-r59usk02 197 2 differences difference NNS cord-014516-r59usk02 197 3 were be VBD cord-014516-r59usk02 197 4 most most RBS cord-014516-r59usk02 197 5 apparent apparent JJ cord-014516-r59usk02 197 6 in in IN cord-014516-r59usk02 197 7 the the DT cord-014516-r59usk02 197 8 RPLA RPLA NNP cord-014516-r59usk02 197 9 view view NN cord-014516-r59usk02 197 10 for for IN cord-014516-r59usk02 197 11 linear linear JJ cord-014516-r59usk02 197 12 measurements measurement NNS cord-014516-r59usk02 197 13 and and CC cord-014516-r59usk02 197 14 RPSA RPSA NNP cord-014516-r59usk02 197 15 view view NN cord-014516-r59usk02 197 16 for for IN cord-014516-r59usk02 197 17 area area NN cord-014516-r59usk02 197 18 measurements measurement NNS cord-014516-r59usk02 197 19 . . . cord-014516-r59usk02 198 1 Dogs dog NNS cord-014516-r59usk02 198 2 with with IN cord-014516-r59usk02 198 3 CHF CHF NNP cord-014516-r59usk02 198 4 had have VBD cord-014516-r59usk02 198 5 worse bad JJR cord-014516-r59usk02 198 6 function function NN cord-014516-r59usk02 198 7 than than IN cord-014516-r59usk02 198 8 all all DT cord-014516-r59usk02 198 9 other other JJ cord-014516-r59usk02 198 10 groups group NNS cord-014516-r59usk02 198 11 , , , cord-014516-r59usk02 198 12 which which WDT cord-014516-r59usk02 198 13 differed differ VBD cord-014516-r59usk02 198 14 variably variably RB cord-014516-r59usk02 198 15 depending depend VBG cord-014516-r59usk02 198 16 on on IN cord-014516-r59usk02 198 17 the the DT cord-014516-r59usk02 198 18 functional functional JJ cord-014516-r59usk02 198 19 index index NN cord-014516-r59usk02 198 20 being be VBG cord-014516-r59usk02 198 21 examined examine VBN cord-014516-r59usk02 198 22 . . . cord-014516-r59usk02 199 1 LAarea LAarea NNP cord-014516-r59usk02 199 2 ACT ACT NNP cord-014516-r59usk02 199 3 showed show VBD cord-014516-r59usk02 199 4 the the DT cord-014516-r59usk02 199 5 best good JJS cord-014516-r59usk02 199 6 ability ability NN cord-014516-r59usk02 199 7 to to TO cord-014516-r59usk02 199 8 discriminate discriminate VB cord-014516-r59usk02 199 9 between between IN cord-014516-r59usk02 199 10 B2 b2 NN cord-014516-r59usk02 199 11 and and CC cord-014516-r59usk02 199 12 CHF CHF NNP cord-014516-r59usk02 199 13 dogs dog NNS cord-014516-r59usk02 199 14 , , , cord-014516-r59usk02 199 15 with with IN cord-014516-r59usk02 199 16 a a DT cord-014516-r59usk02 199 17 95 95 CD cord-014516-r59usk02 199 18 % % NN cord-014516-r59usk02 199 19 specificity specificity NN cord-014516-r59usk02 199 20 , , , cord-014516-r59usk02 199 21 69 69 CD cord-014516-r59usk02 199 22 % % NN cord-014516-r59usk02 199 23 sensitivity sensitivity NN cord-014516-r59usk02 199 24 and and CC cord-014516-r59usk02 199 25 an an DT cord-014516-r59usk02 199 26 AUC AUC NNP cord-014516-r59usk02 199 27 of of IN cord-014516-r59usk02 199 28 0.84 0.84 CD cord-014516-r59usk02 199 29 , , , cord-014516-r59usk02 199 30 but but CC cord-014516-r59usk02 199 31 this this DT cord-014516-r59usk02 199 32 was be VBD cord-014516-r59usk02 199 33 no no RB cord-014516-r59usk02 199 34 better well JJR cord-014516-r59usk02 199 35 than than IN cord-014516-r59usk02 199 36 use use NN cord-014516-r59usk02 199 37 of of IN cord-014516-r59usk02 199 38 LA LA NNP cord-014516-r59usk02 199 39 : : : cord-014516-r59usk02 199 40 AO AO NNP cord-014516-r59usk02 199 41 measurements measurement NNS cord-014516-r59usk02 199 42 . . . cord-014516-r59usk02 200 1 Our -PRON- PRP$ cord-014516-r59usk02 200 2 data datum NNS cord-014516-r59usk02 200 3 suggest suggest VBP cord-014516-r59usk02 200 4 that that IN cord-014516-r59usk02 200 5 LA LA NNP cord-014516-r59usk02 200 6 function function NN cord-014516-r59usk02 200 7 differs differ VBZ cord-014516-r59usk02 200 8 between between IN cord-014516-r59usk02 200 9 dogs dog NNS cord-014516-r59usk02 200 10 with with IN cord-014516-r59usk02 200 11 differing differ VBG cord-014516-r59usk02 200 12 severities severity NNS cord-014516-r59usk02 200 13 of of IN cord-014516-r59usk02 200 14 MMVD MMVD NNP cord-014516-r59usk02 200 15 , , , cord-014516-r59usk02 200 16 but but CC cord-014516-r59usk02 200 17 does do VBZ cord-014516-r59usk02 200 18 not not RB cord-014516-r59usk02 200 19 provide provide VB cord-014516-r59usk02 200 20 a a DT cord-014516-r59usk02 200 21 clear clear JJ cord-014516-r59usk02 200 22 distinction distinction NN cord-014516-r59usk02 200 23 between between IN cord-014516-r59usk02 200 24 dogs dog NNS cord-014516-r59usk02 200 25 with with IN cord-014516-r59usk02 200 26 subclinical subclinical JJ cord-014516-r59usk02 200 27 disease disease NN cord-014516-r59usk02 200 28 and and CC cord-014516-r59usk02 200 29 CHF CHF NNP cord-014516-r59usk02 200 30 . . . cord-014516-r59usk02 201 1 No no DT cord-014516-r59usk02 201 2 conflicts conflict NNS cord-014516-r59usk02 201 3 of of IN cord-014516-r59usk02 201 4 interest interest NN cord-014516-r59usk02 201 5 reported report VBN cord-014516-r59usk02 201 6 . . . cord-014516-r59usk02 202 1 Materials material NNS cord-014516-r59usk02 202 2 and and CC cord-014516-r59usk02 202 3 Methods method NNS cord-014516-r59usk02 202 4 : : : cord-014516-r59usk02 202 5 3DE 3de CD cord-014516-r59usk02 202 6 was be VBD cord-014516-r59usk02 202 7 used use VBN cord-014516-r59usk02 202 8 to to TO cord-014516-r59usk02 202 9 evaluate evaluate VB cord-014516-r59usk02 202 10 85 85 CD cord-014516-r59usk02 202 11 consecutive consecutive JJ cord-014516-r59usk02 202 12 , , , cord-014516-r59usk02 202 13 non non JJ cord-014516-r59usk02 202 14 - - JJ cord-014516-r59usk02 202 15 sedated sedated JJ cord-014516-r59usk02 202 16 dogs dog NNS cord-014516-r59usk02 202 17 that that WDT cord-014516-r59usk02 202 18 weighed weigh VBD cord-014516-r59usk02 202 19 more more JJR cord-014516-r59usk02 202 20 than than IN cord-014516-r59usk02 202 21 5 5 CD cord-014516-r59usk02 202 22 kg kg NNS cord-014516-r59usk02 202 23 . . . cord-014516-r59usk02 203 1 The the DT cord-014516-r59usk02 203 2 study study NN cord-014516-r59usk02 203 3 population population NN cord-014516-r59usk02 203 4 for for IN cord-014516-r59usk02 203 5 the the DT cord-014516-r59usk02 203 6 morphologic morphologic JJ cord-014516-r59usk02 203 7 study study NN cord-014516-r59usk02 203 8 included include VBD cord-014516-r59usk02 203 9 15 15 CD cord-014516-r59usk02 203 10 normal normal JJ cord-014516-r59usk02 203 11 dogs dog NNS cord-014516-r59usk02 203 12 , , , cord-014516-r59usk02 203 13 and and CC cord-014516-r59usk02 203 14 41 41 CD cord-014516-r59usk02 203 15 dogs dog NNS cord-014516-r59usk02 203 16 with with IN cord-014516-r59usk02 203 17 ACVIM ACVIM NNP cord-014516-r59usk02 203 18 Stages stage NNS cord-014516-r59usk02 203 19 B1 b1 NN cord-014516-r59usk02 203 20 or or CC cord-014516-r59usk02 203 21 B2-C B2-C NNP cord-014516-r59usk02 203 22 MMVD MMVD NNP cord-014516-r59usk02 203 23 . . . cord-014516-r59usk02 204 1 3DE 3de CD cord-014516-r59usk02 204 2 image image NN cord-014516-r59usk02 204 3 data datum NNS cord-014516-r59usk02 204 4 were be VBD cord-014516-r59usk02 204 5 digitally digitally RB cord-014516-r59usk02 204 6 recorded record VBN cord-014516-r59usk02 204 7 and and CC cord-014516-r59usk02 204 8 then then RB cord-014516-r59usk02 204 9 analyzed analyze VBD cord-014516-r59usk02 204 10 offline offline RB cord-014516-r59usk02 204 11 , , , cord-014516-r59usk02 204 12 using use VBG cord-014516-r59usk02 204 13 commercially commercially RB cord-014516-r59usk02 204 14 available available JJ cord-014516-r59usk02 204 15 software software NN cord-014516-r59usk02 204 16 . . . cord-014516-r59usk02 205 1 Results result NNS cord-014516-r59usk02 205 2 : : : cord-014516-r59usk02 206 1 3DE 3de CD cord-014516-r59usk02 206 2 image image NN cord-014516-r59usk02 206 3 acquisition acquisition NN cord-014516-r59usk02 206 4 was be VBD cord-014516-r59usk02 206 5 feasible feasible JJ cord-014516-r59usk02 206 6 in in IN cord-014516-r59usk02 206 7 67/85 67/85 CD cord-014516-r59usk02 206 8 ( ( -LRB- cord-014516-r59usk02 206 9 78.8 78.8 CD cord-014516-r59usk02 206 10 % % NN cord-014516-r59usk02 206 11 ) ) -RRB- cord-014516-r59usk02 206 12 consecutive consecutive JJ cord-014516-r59usk02 206 13 dogs dog NNS cord-014516-r59usk02 206 14 . . . cord-014516-r59usk02 207 1 Patient patient JJ cord-014516-r59usk02 207 2 anxiety anxiety NN cord-014516-r59usk02 207 3 ( ( -LRB- cord-014516-r59usk02 207 4 6 6 CD cord-014516-r59usk02 207 5 ) ) -RRB- cord-014516-r59usk02 207 6 , , , cord-014516-r59usk02 207 7 arrhythmias arrhythmia NNS cord-014516-r59usk02 207 8 ( ( -LRB- cord-014516-r59usk02 207 9 6 6 CD cord-014516-r59usk02 207 10 ) ) -RRB- cord-014516-r59usk02 207 11 and and CC cord-014516-r59usk02 207 12 panting pant VBG cord-014516-r59usk02 207 13 ( ( -LRB- cord-014516-r59usk02 207 14 5 5 LS cord-014516-r59usk02 207 15 ) ) -RRB- cord-014516-r59usk02 207 16 explained explain VBD cord-014516-r59usk02 207 17 failure failure NN cord-014516-r59usk02 207 18 to to TO cord-014516-r59usk02 207 19 obtain obtain VB cord-014516-r59usk02 207 20 a a DT cord-014516-r59usk02 207 21 3DE 3de CD cord-014516-r59usk02 207 22 dataset dataset NN cord-014516-r59usk02 207 23 . . . cord-014516-r59usk02 208 1 Fortyone Fortyone NNP cord-014516-r59usk02 208 2 of of IN cord-014516-r59usk02 208 3 67 67 CD cord-014516-r59usk02 208 4 ( ( -LRB- cord-014516-r59usk02 208 5 61.2 61.2 CD cord-014516-r59usk02 208 6 % % NN cord-014516-r59usk02 208 7 ) ) -RRB- cord-014516-r59usk02 208 8 datasets dataset NNS cord-014516-r59usk02 208 9 were be VBD cord-014516-r59usk02 208 10 of of IN cord-014516-r59usk02 208 11 analyzable analyzable JJ cord-014516-r59usk02 208 12 quality quality NN cord-014516-r59usk02 208 13 . . . cord-014516-r59usk02 209 1 Body body NN cord-014516-r59usk02 209 2 weight weight NN cord-014516-r59usk02 209 3 and and CC cord-014516-r59usk02 209 4 heart heart NN cord-014516-r59usk02 209 5 rate rate NN cord-014516-r59usk02 209 6 were be VBD cord-014516-r59usk02 209 7 significantly significantly RB cord-014516-r59usk02 209 8 lower low JJR cord-014516-r59usk02 209 9 in in IN cord-014516-r59usk02 209 10 dogs dog NNS cord-014516-r59usk02 209 11 for for IN cord-014516-r59usk02 209 12 which which WDT cord-014516-r59usk02 209 13 it -PRON- PRP cord-014516-r59usk02 209 14 was be VBD cord-014516-r59usk02 209 15 possible possible JJ cord-014516-r59usk02 209 16 to to TO cord-014516-r59usk02 209 17 perform perform VB cord-014516-r59usk02 209 18 3DE 3de CD cord-014516-r59usk02 209 19 . . . cord-014516-r59usk02 210 1 Dogs dog NNS cord-014516-r59usk02 210 2 with with IN cord-014516-r59usk02 210 3 analyzable analyzable JJ cord-014516-r59usk02 210 4 3DE 3de CD cord-014516-r59usk02 210 5 datasets dataset NNS cord-014516-r59usk02 210 6 were be VBD cord-014516-r59usk02 210 7 significantly significantly RB cord-014516-r59usk02 210 8 older old JJR cord-014516-r59usk02 210 9 and and CC cord-014516-r59usk02 210 10 weighed weigh VBD cord-014516-r59usk02 210 11 less less JJR cord-014516-r59usk02 210 12 than than IN cord-014516-r59usk02 210 13 dogs dog NNS cord-014516-r59usk02 210 14 in in IN cord-014516-r59usk02 210 15 which which WDT cord-014516-r59usk02 210 16 3DE 3de PRP cord-014516-r59usk02 210 17 could could MD cord-014516-r59usk02 210 18 not not RB cord-014516-r59usk02 210 19 be be VB cord-014516-r59usk02 210 20 analyzed analyze VBN cord-014516-r59usk02 210 21 . . . cord-014516-r59usk02 211 1 The the DT cord-014516-r59usk02 211 2 mitral mitral JJ cord-014516-r59usk02 211 3 valve valve NN cord-014516-r59usk02 211 4 of of IN cord-014516-r59usk02 211 5 normal normal JJ cord-014516-r59usk02 211 6 dogs dog NNS cord-014516-r59usk02 211 7 is be VBZ cord-014516-r59usk02 211 8 saddle saddle NN cord-014516-r59usk02 211 9 shaped shape VBN cord-014516-r59usk02 211 10 ( ( -LRB- cord-014516-r59usk02 211 11 annulus annulus NN cord-014516-r59usk02 211 12 height height NN cord-014516-r59usk02 211 13 to to IN cord-014516-r59usk02 211 14 commissural commissural NNP cord-014516-r59usk02 211 15 width width NN cord-014516-r59usk02 211 16 ratio ratio NN cord-014516-r59usk02 211 17 ( ( -LRB- cord-014516-r59usk02 211 18 AHCWR AHCWR NNP cord-014516-r59usk02 211 19 ) ) -RRB- cord-014516-r59usk02 211 20 : : : cord-014516-r59usk02 211 21 0.22 0.22 CD cord-014516-r59usk02 211 22 AE AE NNP cord-014516-r59usk02 211 23 0.06 0.06 CD cord-014516-r59usk02 212 1 [ [ -LRB- cord-014516-r59usk02 212 2 mean mean UH cord-014516-r59usk02 212 3 AE AE NNP cord-014516-r59usk02 212 4 SD SD NNP cord-014516-r59usk02 212 5 ] ] -RRB- cord-014516-r59usk02 212 6 ) ) -RRB- cord-014516-r59usk02 213 1 and and CC cord-014516-r59usk02 213 2 has have VBZ cord-014516-r59usk02 213 3 an an DT cord-014516-r59usk02 213 4 elliptical elliptical JJ cord-014516-r59usk02 213 5 annulus annulus NN cord-014516-r59usk02 213 6 ( ( -LRB- cord-014516-r59usk02 213 7 sphericity sphericity NN cord-014516-r59usk02 213 8 index index NN cord-014516-r59usk02 213 9 ( ( -LRB- cord-014516-r59usk02 213 10 SI SI NNP cord-014516-r59usk02 213 11 ) ) -RRB- cord-014516-r59usk02 213 12 : : : cord-014516-r59usk02 213 13 0.91 0.91 CD cord-014516-r59usk02 213 14 AE AE NNP cord-014516-r59usk02 213 15 0.07 0.07 CD cord-014516-r59usk02 213 16 ) ) -RRB- cord-014516-r59usk02 213 17 . . . cord-014516-r59usk02 214 1 The the DT cord-014516-r59usk02 214 2 following follow VBG cord-014516-r59usk02 214 3 measurements measurement NNS cord-014516-r59usk02 214 4 were be VBD cord-014516-r59usk02 214 5 significantly significantly RB cord-014516-r59usk02 214 6 related relate VBN cord-014516-r59usk02 214 7 to to IN cord-014516-r59usk02 214 8 body body NN cord-014516-r59usk02 214 9 surface surface NN cord-014516-r59usk02 214 10 area area NN cord-014516-r59usk02 214 11 ( ( -LRB- cord-014516-r59usk02 214 12 BSA BSA NNP cord-014516-r59usk02 214 13 ) ) -RRB- cord-014516-r59usk02 215 1 : : : cord-014516-r59usk02 215 2 antero antero NNP cord-014516-r59usk02 215 3 - - HYPH cord-014516-r59usk02 215 4 posterior posterior JJ cord-014516-r59usk02 215 5 diameter diameter NN cord-014516-r59usk02 215 6 ( ( -LRB- cord-014516-r59usk02 215 7 APD APD NNP cord-014516-r59usk02 215 8 ) ) -RRB- cord-014516-r59usk02 216 1 ( ( -LRB- cord-014516-r59usk02 216 2 R r NN cord-014516-r59usk02 216 3 2 2 CD cord-014516-r59usk02 216 4 = = SYM cord-014516-r59usk02 216 5 0.46 0.46 CD cord-014516-r59usk02 216 6 , , , cord-014516-r59usk02 216 7 p p NN cord-014516-r59usk02 216 8 < < XX cord-014516-r59usk02 216 9 0.01 0.01 CD cord-014516-r59usk02 216 10 ) ) -RRB- cord-014516-r59usk02 216 11 , , , cord-014516-r59usk02 216 12 anterolateral anterolateral JJ cord-014516-r59usk02 216 13 - - HYPH cord-014516-r59usk02 216 14 posteromedial posteromedial JJ cord-014516-r59usk02 216 15 diameter diameter NN cord-014516-r59usk02 216 16 ( ( -LRB- cord-014516-r59usk02 216 17 ALPMD ALPMD NNP cord-014516-r59usk02 216 18 ) ) -RRB- cord-014516-r59usk02 217 1 ( ( -LRB- cord-014516-r59usk02 217 2 R r NN cord-014516-r59usk02 217 3 2 2 CD cord-014516-r59usk02 217 4 = = SYM cord-014516-r59usk02 217 5 0.38 0.38 CD cord-014516-r59usk02 217 6 , , , cord-014516-r59usk02 217 7 p p NN cord-014516-r59usk02 217 8 < < XX cord-014516-r59usk02 217 9 0.05 0.05 CD cord-014516-r59usk02 217 10 ) ) -RRB- cord-014516-r59usk02 217 11 , , , cord-014516-r59usk02 217 12 annulus annulus DT cord-014516-r59usk02 217 13 area area NN cord-014516-r59usk02 217 14 ( ( -LRB- cord-014516-r59usk02 217 15 AA AA NNP cord-014516-r59usk02 217 16 ) ) -RRB- cord-014516-r59usk02 218 1 ( ( -LRB- cord-014516-r59usk02 218 2 R r NN cord-014516-r59usk02 218 3 2 2 CD cord-014516-r59usk02 218 4 = = SYM cord-014516-r59usk02 218 5 0.39 0.39 CD cord-014516-r59usk02 218 6 , , , cord-014516-r59usk02 218 7 p p NN cord-014516-r59usk02 218 8 < < XX cord-014516-r59usk02 218 9 0.05 0.05 CD cord-014516-r59usk02 218 10 ) ) -RRB- cord-014516-r59usk02 218 11 , , , cord-014516-r59usk02 218 12 anterior anterior JJ cord-014516-r59usk02 218 13 leaflet leaflet NN cord-014516-r59usk02 218 14 length length NN cord-014516-r59usk02 218 15 ( ( -LRB- cord-014516-r59usk02 218 16 ALL all DT cord-014516-r59usk02 218 17 ) ) -RRB- cord-014516-r59usk02 219 1 ( ( -LRB- cord-014516-r59usk02 219 2 R r NN cord-014516-r59usk02 219 3 2 2 CD cord-014516-r59usk02 219 4 = = SYM cord-014516-r59usk02 219 5 0.38 0.38 CD cord-014516-r59usk02 219 6 , , , cord-014516-r59usk02 219 7 p p NN cord-014516-r59usk02 219 8 < < XX cord-014516-r59usk02 219 9 0.05 0.05 CD cord-014516-r59usk02 219 10 ) ) -RRB- cord-014516-r59usk02 219 11 , , , cord-014516-r59usk02 219 12 anterior anterior NNP cord-014516-r59usk02 219 13 leaflet leaflet NN cord-014516-r59usk02 219 14 area area NN cord-014516-r59usk02 219 15 ( ( -LRB- cord-014516-r59usk02 219 16 ALA ALA NNP cord-014516-r59usk02 219 17 ) ) -RRB- cord-014516-r59usk02 220 1 ( ( -LRB- cord-014516-r59usk02 220 2 R r NN cord-014516-r59usk02 220 3 2 2 CD cord-014516-r59usk02 220 4 = = SYM cord-014516-r59usk02 220 5 0.38 0.38 CD cord-014516-r59usk02 220 6 , , , cord-014516-r59usk02 220 7 p p NN cord-014516-r59usk02 220 8 < < XX cord-014516-r59usk02 220 9 0.05 0.05 CD cord-014516-r59usk02 220 10 ) ) -RRB- cord-014516-r59usk02 220 11 . . . cord-014516-r59usk02 221 1 These these DT cord-014516-r59usk02 221 2 variables variable NNS cord-014516-r59usk02 221 3 were be VBD cord-014516-r59usk02 221 4 indexed index VBN cord-014516-r59usk02 221 5 ( ( -LRB- cord-014516-r59usk02 221 6 i i NN cord-014516-r59usk02 221 7 ) ) -RRB- cord-014516-r59usk02 221 8 to to IN cord-014516-r59usk02 221 9 BSA BSA NNP cord-014516-r59usk02 221 10 for for IN cord-014516-r59usk02 221 11 subsequent subsequent JJ cord-014516-r59usk02 221 12 statistical statistical JJ cord-014516-r59usk02 221 13 analyses analysis NNS cord-014516-r59usk02 221 14 . . . cord-014516-r59usk02 222 1 Dogs dog NNS cord-014516-r59usk02 222 2 with with IN cord-014516-r59usk02 222 3 MMVD MMVD NNP cord-014516-r59usk02 222 4 had have VBD cord-014516-r59usk02 222 5 a a DT cord-014516-r59usk02 222 6 significantly significantly RB cord-014516-r59usk02 222 7 greater great JJR cord-014516-r59usk02 222 8 SI si NN cord-014516-r59usk02 222 9 , , , cord-014516-r59usk02 222 10 non non JJ cord-014516-r59usk02 222 11 - - JJ cord-014516-r59usk02 222 12 planar planar JJ cord-014516-r59usk02 222 13 angle angle NN cord-014516-r59usk02 222 14 , , , cord-014516-r59usk02 222 15 APDi APDi NNS cord-014516-r59usk02 222 16 , , , cord-014516-r59usk02 222 17 ALPMDi ALPMDi NNS cord-014516-r59usk02 222 18 , , , cord-014516-r59usk02 222 19 ALAi ALAi NNS cord-014516-r59usk02 222 20 and and CC cord-014516-r59usk02 222 21 ALLi ALLi NNS cord-014516-r59usk02 222 22 , , , cord-014516-r59usk02 222 23 while while IN cord-014516-r59usk02 222 24 having have VBG cord-014516-r59usk02 222 25 a a DT cord-014516-r59usk02 222 26 significantly significantly RB cord-014516-r59usk02 222 27 lower low JJR cord-014516-r59usk02 222 28 posterior posterior JJ cord-014516-r59usk02 222 29 leaflet leaflet NN cord-014516-r59usk02 222 30 area area NN cord-014516-r59usk02 222 31 ( ( -LRB- cord-014516-r59usk02 222 32 PLA PLA NNP cord-014516-r59usk02 222 33 ) ) -RRB- cord-014516-r59usk02 222 34 , , , cord-014516-r59usk02 222 35 posterior posterior JJ cord-014516-r59usk02 222 36 leaflet leaflet NN cord-014516-r59usk02 222 37 length length NN cord-014516-r59usk02 222 38 ( ( -LRB- cord-014516-r59usk02 222 39 PLL PLL NNP cord-014516-r59usk02 222 40 ) ) -RRB- cord-014516-r59usk02 222 41 , , , cord-014516-r59usk02 222 42 annulus annulus NN cord-014516-r59usk02 222 43 height height NN cord-014516-r59usk02 222 44 ( ( -LRB- cord-014516-r59usk02 222 45 AH AH NNP cord-014516-r59usk02 222 46 ) ) -RRB- cord-014516-r59usk02 222 47 , , , cord-014516-r59usk02 222 48 tenting tent VBG cord-014516-r59usk02 222 49 height height NN cord-014516-r59usk02 222 50 ( ( -LRB- cord-014516-r59usk02 222 51 TH TH NNP cord-014516-r59usk02 222 52 ) ) -RRB- cord-014516-r59usk02 222 53 , , , cord-014516-r59usk02 222 54 tenting tenting NN cord-014516-r59usk02 222 55 volume volume NN cord-014516-r59usk02 222 56 ( ( -LRB- cord-014516-r59usk02 222 57 TV tv NN cord-014516-r59usk02 222 58 ) ) -RRB- cord-014516-r59usk02 222 59 , , , cord-014516-r59usk02 222 60 tenting tenting NN cord-014516-r59usk02 222 61 area area NN cord-014516-r59usk02 222 62 ( ( -LRB- cord-014516-r59usk02 222 63 TA TA NNP cord-014516-r59usk02 222 64 ) ) -RRB- cord-014516-r59usk02 222 65 , , , cord-014516-r59usk02 222 66 and and CC cord-014516-r59usk02 222 67 AHCWR AHCWR NNP cord-014516-r59usk02 222 68 compared compare VBN cord-014516-r59usk02 222 69 to to IN cord-014516-r59usk02 222 70 normal normal JJ cord-014516-r59usk02 222 71 dogs dog NNS cord-014516-r59usk02 222 72 . . . cord-014516-r59usk02 223 1 AH ah UH cord-014516-r59usk02 223 2 , , , cord-014516-r59usk02 223 3 TV tv NN cord-014516-r59usk02 223 4 and and CC cord-014516-r59usk02 223 5 TA TA NNP cord-014516-r59usk02 223 6 were be VBD cord-014516-r59usk02 223 7 significantly significantly RB cord-014516-r59usk02 223 8 greater great JJR cord-014516-r59usk02 223 9 in in IN cord-014516-r59usk02 223 10 normal normal JJ cord-014516-r59usk02 223 11 dogs dog NNS cord-014516-r59usk02 223 12 , , , cord-014516-r59usk02 223 13 compared compare VBN cord-014516-r59usk02 223 14 to to IN cord-014516-r59usk02 223 15 dogs dog NNS cord-014516-r59usk02 223 16 with with IN cord-014516-r59usk02 223 17 MMVD MMVD NNP cord-014516-r59usk02 223 18 . . . cord-014516-r59usk02 224 1 SI SI NNP cord-014516-r59usk02 224 2 , , , cord-014516-r59usk02 224 3 APDi APDi NNS cord-014516-r59usk02 224 4 , , , cord-014516-r59usk02 224 5 AL AL NNP cord-014516-r59usk02 224 6 - - HYPH cord-014516-r59usk02 224 7 PMDi PMDi NNPS cord-014516-r59usk02 224 8 , , , cord-014516-r59usk02 224 9 AAi AAi NNS cord-014516-r59usk02 224 10 , , , cord-014516-r59usk02 224 11 ALAi ALAi NNS cord-014516-r59usk02 224 12 and and CC cord-014516-r59usk02 224 13 ALLi ALLi NNS cord-014516-r59usk02 224 14 were be VBD cord-014516-r59usk02 224 15 significantly significantly RB cord-014516-r59usk02 224 16 greater great JJR cord-014516-r59usk02 224 17 in in IN cord-014516-r59usk02 224 18 dogs dog NNS cord-014516-r59usk02 224 19 with with IN cord-014516-r59usk02 224 20 Stages Stages NNPS cord-014516-r59usk02 224 21 B2-C B2-C NNP cord-014516-r59usk02 224 22 MMVD MMVD NNP cord-014516-r59usk02 224 23 , , , cord-014516-r59usk02 224 24 compared compare VBN cord-014516-r59usk02 224 25 to to IN cord-014516-r59usk02 224 26 normal normal JJ cord-014516-r59usk02 224 27 dogs dog NNS cord-014516-r59usk02 224 28 and and CC cord-014516-r59usk02 224 29 those those DT cord-014516-r59usk02 224 30 in in IN cord-014516-r59usk02 224 31 Stage stage NN cord-014516-r59usk02 224 32 B1 b1 NN cord-014516-r59usk02 224 33 . . . cord-014516-r59usk02 225 1 PLL PLL NNP cord-014516-r59usk02 225 2 and and CC cord-014516-r59usk02 225 3 PLA PLA NNP cord-014516-r59usk02 225 4 were be VBD cord-014516-r59usk02 225 5 significantly significantly RB cord-014516-r59usk02 225 6 lower low JJR cord-014516-r59usk02 225 7 in in IN cord-014516-r59usk02 225 8 B2-C B2-C NNP cord-014516-r59usk02 225 9 dogs dog NNS cord-014516-r59usk02 225 10 , , , cord-014516-r59usk02 225 11 compared compare VBN cord-014516-r59usk02 225 12 to to IN cord-014516-r59usk02 225 13 normal normal JJ cord-014516-r59usk02 225 14 dogs dog NNS cord-014516-r59usk02 225 15 . . . cord-014516-r59usk02 226 1 TH TH NNP cord-014516-r59usk02 226 2 was be VBD cord-014516-r59usk02 226 3 significantly significantly RB cord-014516-r59usk02 226 4 different different JJ cord-014516-r59usk02 226 5 between between IN cord-014516-r59usk02 226 6 the the DT cord-014516-r59usk02 226 7 three three CD cord-014516-r59usk02 226 8 groups group NNS cord-014516-r59usk02 226 9 ; ; : cord-014516-r59usk02 226 10 greatest great JJS cord-014516-r59usk02 226 11 in in IN cord-014516-r59usk02 226 12 normal normal JJ cord-014516-r59usk02 226 13 dogs dog NNS cord-014516-r59usk02 226 14 and and CC cord-014516-r59usk02 226 15 lowest low JJS cord-014516-r59usk02 226 16 in in IN cord-014516-r59usk02 226 17 dogs dog NNS cord-014516-r59usk02 226 18 in in IN cord-014516-r59usk02 226 19 Stages Stages NNP cord-014516-r59usk02 226 20 B2-C B2-C NNP cord-014516-r59usk02 226 21 , , , cord-014516-r59usk02 226 22 suggesting suggest VBG cord-014516-r59usk02 226 23 that that IN cord-014516-r59usk02 226 24 flattening flattening NN cord-014516-r59usk02 226 25 of of IN cord-014516-r59usk02 226 26 the the DT cord-014516-r59usk02 226 27 MV MV NNP cord-014516-r59usk02 226 28 occurs occur VBZ cord-014516-r59usk02 226 29 with with IN cord-014516-r59usk02 226 30 disease disease NN cord-014516-r59usk02 226 31 progression progression NN cord-014516-r59usk02 226 32 . . . cord-014516-r59usk02 227 1 Conclusions conclusion NNS cord-014516-r59usk02 227 2 : : : cord-014516-r59usk02 228 1 3DE 3de CD cord-014516-r59usk02 228 2 assessment assessment NN cord-014516-r59usk02 228 3 of of IN cord-014516-r59usk02 228 4 the the DT cord-014516-r59usk02 228 5 canine canine JJ cord-014516-r59usk02 228 6 MV MV NNP cord-014516-r59usk02 228 7 is be VBZ cord-014516-r59usk02 228 8 feasible feasible JJ cord-014516-r59usk02 228 9 . . . cord-014516-r59usk02 229 1 Morphologic morphologic JJ cord-014516-r59usk02 229 2 changes change NNS cord-014516-r59usk02 229 3 associated associate VBN cord-014516-r59usk02 229 4 with with IN cord-014516-r59usk02 229 5 MMVD MMVD NNP cord-014516-r59usk02 229 6 progression progression NN cord-014516-r59usk02 229 7 are be VBP cord-014516-r59usk02 229 8 presented present VBN cord-014516-r59usk02 229 9 . . . cord-014516-r59usk02 230 1 Effective effective JJ cord-014516-r59usk02 230 2 regurgitant regurgitant JJ cord-014516-r59usk02 230 3 orifice orifice NN cord-014516-r59usk02 230 4 area area NN cord-014516-r59usk02 230 5 ( ( -LRB- cord-014516-r59usk02 230 6 EROA EROA NNP cord-014516-r59usk02 230 7 ) ) -RRB- cord-014516-r59usk02 230 8 , , . cord-014516-r59usk02 231 1 calculated calculate VBN cord-014516-r59usk02 231 2 from from IN cord-014516-r59usk02 231 3 a a DT cord-014516-r59usk02 231 4 1dimensional 1dimensional CD cord-014516-r59usk02 231 5 measurement measurement NN cord-014516-r59usk02 231 6 of of IN cord-014516-r59usk02 231 7 the the DT cord-014516-r59usk02 231 8 width width NN cord-014516-r59usk02 231 9 of of IN cord-014516-r59usk02 231 10 vena vena NNP cord-014516-r59usk02 231 11 contracta contracta NNP cord-014516-r59usk02 231 12 ( ( -LRB- cord-014516-r59usk02 231 13 VC VC NNP cord-014516-r59usk02 231 14 ) ) -RRB- cord-014516-r59usk02 231 15 as as IN cord-014516-r59usk02 231 16 the the DT cord-014516-r59usk02 231 17 narrowest narrow JJS cord-014516-r59usk02 231 18 portion portion NN cord-014516-r59usk02 231 19 of of IN cord-014516-r59usk02 231 20 the the DT cord-014516-r59usk02 231 21 proximal proximal JJ cord-014516-r59usk02 231 22 regurgitant regurgitant NN cord-014516-r59usk02 231 23 jet jet NN cord-014516-r59usk02 231 24 , , , cord-014516-r59usk02 231 25 might may MD cord-014516-r59usk02 231 26 be be VB cord-014516-r59usk02 231 27 used use VBN cord-014516-r59usk02 231 28 to to TO cord-014516-r59usk02 231 29 estimate estimate VB cord-014516-r59usk02 231 30 severity severity NN cord-014516-r59usk02 231 31 of of IN cord-014516-r59usk02 231 32 mitral mitral JJ cord-014516-r59usk02 231 33 regurgitation regurgitation NN cord-014516-r59usk02 231 34 ( ( -LRB- cord-014516-r59usk02 231 35 MR MR NNP cord-014516-r59usk02 231 36 ) ) -RRB- cord-014516-r59usk02 231 37 . . . cord-014516-r59usk02 232 1 However however RB cord-014516-r59usk02 232 2 , , , cord-014516-r59usk02 232 3 this this DT cord-014516-r59usk02 232 4 simplified simplified JJ cord-014516-r59usk02 232 5 assumption assumption NN cord-014516-r59usk02 232 6 only only RB cord-014516-r59usk02 232 7 holds hold VBZ cord-014516-r59usk02 232 8 when when WRB cord-014516-r59usk02 232 9 the the DT cord-014516-r59usk02 232 10 EROA EROA NNP cord-014516-r59usk02 232 11 is be VBZ cord-014516-r59usk02 232 12 circular circular JJ cord-014516-r59usk02 232 13 , , , cord-014516-r59usk02 232 14 which which WDT cord-014516-r59usk02 232 15 might may MD cord-014516-r59usk02 232 16 not not RB cord-014516-r59usk02 232 17 be be VB cord-014516-r59usk02 232 18 true true JJ cord-014516-r59usk02 232 19 in in IN cord-014516-r59usk02 232 20 dogs dog NNS cord-014516-r59usk02 232 21 with with IN cord-014516-r59usk02 232 22 myxomatous myxomatous JJ cord-014516-r59usk02 232 23 mitral mitral JJ cord-014516-r59usk02 232 24 valve valve NN cord-014516-r59usk02 232 25 disease disease NN cord-014516-r59usk02 232 26 ( ( -LRB- cord-014516-r59usk02 232 27 MMVD MMVD NNP cord-014516-r59usk02 232 28 ) ) -RRB- cord-014516-r59usk02 232 29 . . . cord-014516-r59usk02 233 1 The the DT cord-014516-r59usk02 233 2 aim aim NN cord-014516-r59usk02 233 3 of of IN cord-014516-r59usk02 233 4 the the DT cord-014516-r59usk02 233 5 study study NN cord-014516-r59usk02 233 6 was be VBD cord-014516-r59usk02 233 7 to to TO cord-014516-r59usk02 233 8 compare compare VB cord-014516-r59usk02 233 9 measured measure VBN cord-014516-r59usk02 233 10 EROA EROA NNP cord-014516-r59usk02 233 11 using use VBG cord-014516-r59usk02 233 12 color color NN cord-014516-r59usk02 233 13 Doppler Doppler NNP cord-014516-r59usk02 233 14 real real JJ cord-014516-r59usk02 233 15 - - HYPH cord-014516-r59usk02 233 16 time time NN cord-014516-r59usk02 233 17 3 3 CD cord-014516-r59usk02 233 18 dimensional dimensional JJ cord-014516-r59usk02 233 19 echocardiography echocardiography NN cord-014516-r59usk02 233 20 ( ( -LRB- cord-014516-r59usk02 233 21 RT3D rt3d NN cord-014516-r59usk02 233 22 ) ) -RRB- cord-014516-r59usk02 233 23 with with IN cord-014516-r59usk02 233 24 calculated calculate VBN cord-014516-r59usk02 233 25 EROA EROA NNP cord-014516-r59usk02 233 26 estimated estimate VBN cord-014516-r59usk02 233 27 by by IN cord-014516-r59usk02 233 28 2 2 CD cord-014516-r59usk02 233 29 dimensional dimensional JJ cord-014516-r59usk02 233 30 echocardiography echocardiography NN cord-014516-r59usk02 233 31 ( ( -LRB- cord-014516-r59usk02 233 32 2D 2D NNP cord-014516-r59usk02 233 33 ) ) -RRB- cord-014516-r59usk02 233 34 in in IN cord-014516-r59usk02 233 35 4 4 CD cord-014516-r59usk02 233 36 chamber chamber NN cord-014516-r59usk02 233 37 ( ( -LRB- cord-014516-r59usk02 233 38 4ch 4ch NN cord-014516-r59usk02 233 39 ) ) -RRB- cord-014516-r59usk02 233 40 and and CC cord-014516-r59usk02 233 41 2 2 CD cord-014516-r59usk02 233 42 chamber chamber NN cord-014516-r59usk02 233 43 ( ( -LRB- cord-014516-r59usk02 233 44 2ch 2ch NN cord-014516-r59usk02 233 45 ) ) -RRB- cord-014516-r59usk02 233 46 views view NNS cord-014516-r59usk02 233 47 of of IN cord-014516-r59usk02 233 48 the the DT cord-014516-r59usk02 233 49 left left JJ cord-014516-r59usk02 233 50 ventricle ventricle NN cord-014516-r59usk02 233 51 ( ( -LRB- cord-014516-r59usk02 233 52 LV LV NNP cord-014516-r59usk02 233 53 ) ) -RRB- cord-014516-r59usk02 233 54 in in IN cord-014516-r59usk02 233 55 dogs dog NNS cord-014516-r59usk02 233 56 with with IN cord-014516-r59usk02 233 57 MMVD MMVD NNP cord-014516-r59usk02 233 58 . . . cord-014516-r59usk02 234 1 Ninety ninety CD cord-014516-r59usk02 234 2 - - HYPH cord-014516-r59usk02 234 3 three three CD cord-014516-r59usk02 234 4 privately privately RB cord-014516-r59usk02 234 5 owned own VBN cord-014516-r59usk02 234 6 dogs dog NNS cord-014516-r59usk02 234 7 of of IN cord-014516-r59usk02 234 8 32 32 CD cord-014516-r59usk02 234 9 breeds breed NNS cord-014516-r59usk02 234 10 diagnosed diagnose VBN cord-014516-r59usk02 234 11 with with IN cord-014516-r59usk02 234 12 naturally naturally RB cord-014516-r59usk02 234 13 acquired acquire VBN cord-014516-r59usk02 234 14 MMVD MMVD NNP cord-014516-r59usk02 234 15 were be VBD cord-014516-r59usk02 234 16 examined examine VBN cord-014516-r59usk02 234 17 using use VBG cord-014516-r59usk02 234 18 2D 2d NN cord-014516-r59usk02 234 19 and and CC cord-014516-r59usk02 234 20 RT3D. RT3D. NNPS cord-014516-r59usk02 235 1 According accord VBG cord-014516-r59usk02 235 2 to to IN cord-014516-r59usk02 235 3 the the DT cord-014516-r59usk02 235 4 ACVIM ACVIM NNP cord-014516-r59usk02 235 5 classification classification NN cord-014516-r59usk02 235 6 of of IN cord-014516-r59usk02 235 7 congestive congestive JJ cord-014516-r59usk02 235 8 heart heart NN cord-014516-r59usk02 235 9 failure failure NN cord-014516-r59usk02 235 10 ( ( -LRB- cord-014516-r59usk02 235 11 CHF CHF NNP cord-014516-r59usk02 235 12 ) ) -RRB- cord-014516-r59usk02 235 13 , , , cord-014516-r59usk02 235 14 23 23 CD cord-014516-r59usk02 235 15 dogs dog NNS cord-014516-r59usk02 235 16 were be VBD cord-014516-r59usk02 235 17 classified classify VBN cord-014516-r59usk02 235 18 with with IN cord-014516-r59usk02 235 19 CHF CHF NNP cord-014516-r59usk02 235 20 ( ( -LRB- cord-014516-r59usk02 235 21 2 2 CD cord-014516-r59usk02 235 22 in in IN cord-014516-r59usk02 235 23 class class NN cord-014516-r59usk02 235 24 C1 c1 NN cord-014516-r59usk02 235 25 and and CC cord-014516-r59usk02 235 26 21 21 CD cord-014516-r59usk02 235 27 in in IN cord-014516-r59usk02 235 28 class class NN cord-014516-r59usk02 235 29 C2 C2 NNP cord-014516-r59usk02 235 30 ) ) -RRB- cord-014516-r59usk02 235 31 and and CC cord-014516-r59usk02 235 32 70 70 CD cord-014516-r59usk02 235 33 dogs dog NNS cord-014516-r59usk02 235 34 without without IN cord-014516-r59usk02 235 35 CHF CHF NNP cord-014516-r59usk02 235 36 ( ( -LRB- cord-014516-r59usk02 235 37 65 65 CD cord-014516-r59usk02 235 38 dogs dog NNS cord-014516-r59usk02 235 39 in in IN cord-014516-r59usk02 235 40 class class NN cord-014516-r59usk02 235 41 B1 b1 NN cord-014516-r59usk02 235 42 and and CC cord-014516-r59usk02 235 43 5 5 CD cord-014516-r59usk02 235 44 dogs dog NNS cord-014516-r59usk02 235 45 in in IN cord-014516-r59usk02 235 46 class class NN cord-014516-r59usk02 235 47 B2 b2 NN cord-014516-r59usk02 235 48 ) ) -RRB- cord-014516-r59usk02 235 49 . . . cord-014516-r59usk02 236 1 Age age NN cord-014516-r59usk02 236 2 ranged range VBD cord-014516-r59usk02 236 3 from from IN cord-014516-r59usk02 236 4 1 1 CD cord-014516-r59usk02 236 5 to to IN cord-014516-r59usk02 236 6 15 15 CD cord-014516-r59usk02 236 7 years year NNS cord-014516-r59usk02 236 8 ( ( -LRB- cord-014516-r59usk02 236 9 median median NN cord-014516-r59usk02 236 10 10 10 CD cord-014516-r59usk02 236 11 years year NNS cord-014516-r59usk02 236 12 ) ) -RRB- cord-014516-r59usk02 236 13 , , , cord-014516-r59usk02 236 14 and and CC cord-014516-r59usk02 236 15 body body NN cord-014516-r59usk02 236 16 weight weight NN cord-014516-r59usk02 236 17 ranged range VBD cord-014516-r59usk02 236 18 from from IN cord-014516-r59usk02 236 19 2.5 2.5 CD cord-014516-r59usk02 236 20 to to TO cord-014516-r59usk02 236 21 35 35 CD cord-014516-r59usk02 236 22 kg kg NNS cord-014516-r59usk02 236 23 ( ( -LRB- cord-014516-r59usk02 236 24 median median NN cord-014516-r59usk02 236 25 10 10 CD cord-014516-r59usk02 236 26 kg kg NNS cord-014516-r59usk02 236 27 ) ) -RRB- cord-014516-r59usk02 236 28 . . . cord-014516-r59usk02 237 1 Fifty fifty CD cord-014516-r59usk02 237 2 - - HYPH cord-014516-r59usk02 237 3 nine nine CD cord-014516-r59usk02 237 4 males male NNS cord-014516-r59usk02 237 5 ( ( -LRB- cord-014516-r59usk02 237 6 63 63 CD cord-014516-r59usk02 237 7 % % NN cord-014516-r59usk02 237 8 ) ) -RRB- cord-014516-r59usk02 237 9 and and CC cord-014516-r59usk02 237 10 34 34 CD cord-014516-r59usk02 237 11 females female NNS cord-014516-r59usk02 237 12 ( ( -LRB- cord-014516-r59usk02 237 13 37 37 CD cord-014516-r59usk02 237 14 % % NN cord-014516-r59usk02 237 15 ) ) -RRB- cord-014516-r59usk02 237 16 were be VBD cord-014516-r59usk02 237 17 included include VBN cord-014516-r59usk02 237 18 , , , cord-014516-r59usk02 237 19 and and CC cord-014516-r59usk02 237 20 heart heart NN cord-014516-r59usk02 237 21 rate rate NN cord-014516-r59usk02 237 22 ranged range VBD cord-014516-r59usk02 237 23 from from IN cord-014516-r59usk02 237 24 80 80 CD cord-014516-r59usk02 237 25 to to TO cord-014516-r59usk02 237 26 222 222 CD cord-014516-r59usk02 237 27 beats beat NNS cord-014516-r59usk02 237 28 / / SYM cord-014516-r59usk02 237 29 minute minute NN cord-014516-r59usk02 237 30 ( ( -LRB- cord-014516-r59usk02 237 31 median median NN cord-014516-r59usk02 237 32 126 126 CD cord-014516-r59usk02 237 33 b b NN cord-014516-r59usk02 237 34 / / SYM cord-014516-r59usk02 237 35 min min NN cord-014516-r59usk02 237 36 ) ) -RRB- cord-014516-r59usk02 237 37 . . . cord-014516-r59usk02 238 1 EROA EROA NNP cord-014516-r59usk02 238 2 was be VBD cord-014516-r59usk02 238 3 calculated calculate VBN cord-014516-r59usk02 238 4 from from IN cord-014516-r59usk02 238 5 2D 2d JJ cord-014516-r59usk02 238 6 measurements measurement NNS cord-014516-r59usk02 238 7 of of IN cord-014516-r59usk02 238 8 VC VC NNP cord-014516-r59usk02 238 9 diameter diameter NN cord-014516-r59usk02 238 10 , , , cord-014516-r59usk02 238 11 in in IN cord-014516-r59usk02 238 12 the the DT cord-014516-r59usk02 238 13 4ch 4ch JJ cord-014516-r59usk02 238 14 view view NN cord-014516-r59usk02 238 15 only only RB cord-014516-r59usk02 238 16 ( ( -LRB- cord-014516-r59usk02 238 17 assuming assume VBG cord-014516-r59usk02 238 18 a a DT cord-014516-r59usk02 238 19 circular circular JJ cord-014516-r59usk02 238 20 regurgitant regurgitant JJ cord-014516-r59usk02 238 21 orifice orifice NN cord-014516-r59usk02 238 22 ) ) -RRB- cord-014516-r59usk02 238 23 , , , cord-014516-r59usk02 238 24 and and CC cord-014516-r59usk02 238 25 from from IN cord-014516-r59usk02 238 26 measurements measurement NNS cord-014516-r59usk02 238 27 of of IN cord-014516-r59usk02 238 28 VC VC NNP cord-014516-r59usk02 238 29 diameter diameter NN cord-014516-r59usk02 238 30 in in IN cord-014516-r59usk02 238 31 both both CC cord-014516-r59usk02 238 32 4ch 4ch JJ cord-014516-r59usk02 238 33 and and CC cord-014516-r59usk02 238 34 2ch 2ch JJ cord-014516-r59usk02 238 35 views view NNS cord-014516-r59usk02 238 36 ( ( -LRB- cord-014516-r59usk02 238 37 assuming assume VBG cord-014516-r59usk02 238 38 an an DT cord-014516-r59usk02 238 39 eliptical eliptical JJ cord-014516-r59usk02 238 40 regurgitant regurgitant JJ cord-014516-r59usk02 238 41 orifice orifice NN cord-014516-r59usk02 238 42 ) ) -RRB- cord-014516-r59usk02 238 43 of of IN cord-014516-r59usk02 238 44 LV LV NNP cord-014516-r59usk02 238 45 . . . cord-014516-r59usk02 239 1 Bland Bland NNP cord-014516-r59usk02 239 2 - - HYPH cord-014516-r59usk02 239 3 Altman Altman NNP cord-014516-r59usk02 239 4 plots plot NNS cord-014516-r59usk02 239 5 were be VBD cord-014516-r59usk02 239 6 used use VBN cord-014516-r59usk02 239 7 to to TO cord-014516-r59usk02 239 8 compare compare VB cord-014516-r59usk02 239 9 EROA EROA NNP cord-014516-r59usk02 239 10 measured measure VBN cord-014516-r59usk02 239 11 by by IN cord-014516-r59usk02 239 12 RT3D RT3D NNP cord-014516-r59usk02 239 13 with with IN cord-014516-r59usk02 239 14 calculated calculate VBN cord-014516-r59usk02 239 15 EROA EROA NNP cord-014516-r59usk02 239 16 obtained obtain VBD cord-014516-r59usk02 239 17 from from IN cord-014516-r59usk02 239 18 2D 2D NNP cord-014516-r59usk02 239 19 4ch 4ch NN cord-014516-r59usk02 239 20 and and CC cord-014516-r59usk02 239 21 4ch/ 4ch/ CD cord-014516-r59usk02 239 22 2ch 2ch NN cord-014516-r59usk02 239 23 LV LV NNP cord-014516-r59usk02 239 24 views view VBZ cord-014516-r59usk02 239 25 . . . cord-014516-r59usk02 240 1 None none NN cord-014516-r59usk02 240 2 of of IN cord-014516-r59usk02 240 3 the the DT cord-014516-r59usk02 240 4 2D 2D NNP cord-014516-r59usk02 240 5 estimations estimation NNS cord-014516-r59usk02 240 6 of of IN cord-014516-r59usk02 240 7 EROA EROA NNP cord-014516-r59usk02 240 8 showed show VBD cord-014516-r59usk02 240 9 good good JJ cord-014516-r59usk02 240 10 agreement agreement NN cord-014516-r59usk02 240 11 with with IN cord-014516-r59usk02 240 12 the the DT cord-014516-r59usk02 240 13 measured measured JJ cord-014516-r59usk02 240 14 RT3D RT3D NNP cord-014516-r59usk02 240 15 EROA EROA NNP cord-014516-r59usk02 240 16 when when WRB cord-014516-r59usk02 240 17 corrected correct VBD cord-014516-r59usk02 240 18 for for IN cord-014516-r59usk02 240 19 BSA BSA NNP cord-014516-r59usk02 240 20 , , , cord-014516-r59usk02 240 21 and and CC cord-014516-r59usk02 240 22 the the DT cord-014516-r59usk02 240 23 difference difference NN cord-014516-r59usk02 240 24 between between IN cord-014516-r59usk02 240 25 methods method NNS cord-014516-r59usk02 240 26 increased increase VBN cord-014516-r59usk02 240 27 with with IN cord-014516-r59usk02 240 28 increasing increase VBG cord-014516-r59usk02 240 29 EROA EROA NNP cord-014516-r59usk02 240 30 . . . cord-014516-r59usk02 241 1 The the DT cord-014516-r59usk02 241 2 difference difference NN cord-014516-r59usk02 241 3 between between IN cord-014516-r59usk02 241 4 RT3D rt3d NN cord-014516-r59usk02 241 5 and and CC cord-014516-r59usk02 241 6 2D 2d NN cord-014516-r59usk02 241 7 methods method NNS cord-014516-r59usk02 241 8 normalized normalize VBN cord-014516-r59usk02 241 9 to to IN cord-014516-r59usk02 241 10 the the DT cord-014516-r59usk02 241 11 mean mean JJ cord-014516-r59usk02 241 12 EROA EROA NNP cord-014516-r59usk02 241 13 value value NN cord-014516-r59usk02 241 14 did do VBD cord-014516-r59usk02 241 15 not not RB cord-014516-r59usk02 241 16 increase increase VB cord-014516-r59usk02 241 17 with with IN cord-014516-r59usk02 241 18 increasing increase VBG cord-014516-r59usk02 241 19 EROA EROA NNP cord-014516-r59usk02 241 20 , , , cord-014516-r59usk02 241 21 but but CC cord-014516-r59usk02 241 22 showed show VBD cord-014516-r59usk02 241 23 a a DT cord-014516-r59usk02 241 24 systematic systematic JJ cord-014516-r59usk02 241 25 underestimation underestimation NN cord-014516-r59usk02 241 26 of of IN cord-014516-r59usk02 241 27 EROA EROA NNP cord-014516-r59usk02 241 28 by by IN cord-014516-r59usk02 241 29 60 60 CD cord-014516-r59usk02 241 30 % % NN cord-014516-r59usk02 241 31 ( ( -LRB- cord-014516-r59usk02 241 32 4ch 4ch NN cord-014516-r59usk02 241 33 ) ) -RRB- cord-014516-r59usk02 241 34 and and CC cord-014516-r59usk02 241 35 40 40 CD cord-014516-r59usk02 241 36 % % NN cord-014516-r59usk02 241 37 ( ( -LRB- cord-014516-r59usk02 241 38 4ch/2ch 4ch/2ch CD cord-014516-r59usk02 241 39 ) ) -RRB- cord-014516-r59usk02 241 40 , , , cord-014516-r59usk02 241 41 respectively respectively RB cord-014516-r59usk02 241 42 , , , cord-014516-r59usk02 241 43 compared compare VBN cord-014516-r59usk02 241 44 to to IN cord-014516-r59usk02 241 45 RT3D. RT3D. NNS cord-014516-r59usk02 242 1 The the DT cord-014516-r59usk02 242 2 beat beat NN cord-014516-r59usk02 242 3 - - HYPH cord-014516-r59usk02 242 4 to to IN cord-014516-r59usk02 242 5 - - HYPH cord-014516-r59usk02 242 6 beat beat NN cord-014516-r59usk02 242 7 variation variation NN cord-014516-r59usk02 242 8 of of IN cord-014516-r59usk02 242 9 EROA EROA NNP cord-014516-r59usk02 242 10 assessed assess VBN cord-014516-r59usk02 242 11 by by IN cord-014516-r59usk02 242 12 RT3D RT3D NNP cord-014516-r59usk02 242 13 ( ( -LRB- cord-014516-r59usk02 242 14 n n NN cord-014516-r59usk02 242 15 = = SYM cord-014516-r59usk02 242 16 56 56 CD cord-014516-r59usk02 242 17 ) ) -RRB- cord-014516-r59usk02 242 18 had have VBD cord-014516-r59usk02 242 19 a a DT cord-014516-r59usk02 242 20 coefficient coefficient NN cord-014516-r59usk02 242 21 of of IN cord-014516-r59usk02 242 22 variation variation NN cord-014516-r59usk02 242 23 ranging range VBG cord-014516-r59usk02 242 24 from from IN cord-014516-r59usk02 242 25 2.8 2.8 CD cord-014516-r59usk02 242 26 % % NN cord-014516-r59usk02 242 27 to to IN cord-014516-r59usk02 242 28 68 68 CD cord-014516-r59usk02 242 29 % % NN cord-014516-r59usk02 242 30 ( ( -LRB- cord-014516-r59usk02 242 31 median median JJ cord-014516-r59usk02 242 32 30 30 CD cord-014516-r59usk02 242 33 % % NN cord-014516-r59usk02 242 34 ) ) -RRB- cord-014516-r59usk02 242 35 . . . cord-014516-r59usk02 243 1 In in IN cord-014516-r59usk02 243 2 conclusion conclusion NN cord-014516-r59usk02 243 3 , , , cord-014516-r59usk02 243 4 substituting substitute VBG cord-014516-r59usk02 243 5 assessment assessment NN cord-014516-r59usk02 243 6 of of IN cord-014516-r59usk02 243 7 EROA EROA NNP cord-014516-r59usk02 243 8 with with IN cord-014516-r59usk02 243 9 a a DT cord-014516-r59usk02 243 10 measurement measurement NN cord-014516-r59usk02 243 11 of of IN cord-014516-r59usk02 243 12 VC VC NNP cord-014516-r59usk02 243 13 in in IN cord-014516-r59usk02 243 14 1 1 CD cord-014516-r59usk02 243 15 or or CC cord-014516-r59usk02 243 16 2 2 CD cord-014516-r59usk02 243 17 dimensions dimension NNS cord-014516-r59usk02 243 18 might may MD cord-014516-r59usk02 243 19 underestimate underestimate VB cord-014516-r59usk02 243 20 the the DT cord-014516-r59usk02 243 21 MR MR NNP cord-014516-r59usk02 243 22 severity severity NN cord-014516-r59usk02 243 23 in in IN cord-014516-r59usk02 243 24 dogs dog NNS cord-014516-r59usk02 243 25 with with IN cord-014516-r59usk02 243 26 MMVD MMVD NNP cord-014516-r59usk02 243 27 . . . cord-014516-r59usk02 244 1 In in IN cord-014516-r59usk02 244 2 some some DT cord-014516-r59usk02 244 3 dogs dog NNS cord-014516-r59usk02 244 4 , , , cord-014516-r59usk02 244 5 the the DT cord-014516-r59usk02 244 6 beat beat NN cord-014516-r59usk02 244 7 - - HYPH cord-014516-r59usk02 244 8 tobeat tobeat NN cord-014516-r59usk02 244 9 variation variation NN cord-014516-r59usk02 244 10 of of IN cord-014516-r59usk02 244 11 the the DT cord-014516-r59usk02 244 12 EROA EROA NNP cord-014516-r59usk02 244 13 was be VBD cord-014516-r59usk02 244 14 large large JJ cord-014516-r59usk02 244 15 , , , cord-014516-r59usk02 244 16 thereby thereby RB cord-014516-r59usk02 244 17 necessitating necessitate VBG cord-014516-r59usk02 244 18 the the DT cord-014516-r59usk02 244 19 need need NN cord-014516-r59usk02 244 20 for for IN cord-014516-r59usk02 244 21 several several JJ cord-014516-r59usk02 244 22 consecutive consecutive JJ cord-014516-r59usk02 244 23 measurements measurement NNS cord-014516-r59usk02 244 24 . . . cord-014516-r59usk02 245 1 No no DT cord-014516-r59usk02 245 2 conflicts conflict NNS cord-014516-r59usk02 245 3 of of IN cord-014516-r59usk02 245 4 interest interest NN cord-014516-r59usk02 245 5 reported report VBN cord-014516-r59usk02 245 6 . . . cord-014516-r59usk02 246 1 MicroRNAs MicroRNAs NNP cord-014516-r59usk02 246 2 ( ( -LRB- cord-014516-r59usk02 246 3 miRNA miRNA NNP cord-014516-r59usk02 246 4 ) ) -RRB- cord-014516-r59usk02 246 5 are be VBP cord-014516-r59usk02 246 6 short short JJ cord-014516-r59usk02 246 7 ( ( -LRB- cord-014516-r59usk02 246 8 19 19 CD cord-014516-r59usk02 246 9 - - SYM cord-014516-r59usk02 246 10 22 22 CD cord-014516-r59usk02 246 11 nucleotides nucleotide NNS cord-014516-r59usk02 246 12 ) ) -RRB- cord-014516-r59usk02 246 13 , , , cord-014516-r59usk02 246 14 singlestranded singlestranded JJ cord-014516-r59usk02 246 15 , , , cord-014516-r59usk02 246 16 non non JJ cord-014516-r59usk02 246 17 - - JJ cord-014516-r59usk02 246 18 coding coding JJ cord-014516-r59usk02 246 19 RNAs rna NNS cord-014516-r59usk02 246 20 that that WDT cord-014516-r59usk02 246 21 specifically specifically RB cord-014516-r59usk02 246 22 anneal anneal VBP cord-014516-r59usk02 246 23 with with IN cord-014516-r59usk02 246 24 complementary complementary JJ cord-014516-r59usk02 246 25 sequences sequence NNS cord-014516-r59usk02 246 26 in in IN cord-014516-r59usk02 246 27 multiple multiple JJ cord-014516-r59usk02 246 28 mRNA mRNA NNP cord-014516-r59usk02 246 29 targets target NNS cord-014516-r59usk02 246 30 , , , cord-014516-r59usk02 246 31 and and CC cord-014516-r59usk02 246 32 they -PRON- PRP cord-014516-r59usk02 246 33 silence silence VBP cord-014516-r59usk02 246 34 mRNAs mrnas XX cord-014516-r59usk02 246 35 and and CC cord-014516-r59usk02 246 36 suppress suppress VB cord-014516-r59usk02 246 37 downstream downstream JJ cord-014516-r59usk02 246 38 protein protein NN cord-014516-r59usk02 246 39 translation translation NN cord-014516-r59usk02 246 40 . . . cord-014516-r59usk02 247 1 A a DT cord-014516-r59usk02 247 2 miRNA miRNA NNP cord-014516-r59usk02 247 3 can can MD cord-014516-r59usk02 247 4 act act VB cord-014516-r59usk02 247 5 as as IN cord-014516-r59usk02 247 6 a a DT cord-014516-r59usk02 247 7 fine fine JJ cord-014516-r59usk02 247 8 - - HYPH cord-014516-r59usk02 247 9 tuner tuner NN cord-014516-r59usk02 247 10 of of IN cord-014516-r59usk02 247 11 gene gene NN cord-014516-r59usk02 247 12 expression expression NN cord-014516-r59usk02 247 13 or or CC cord-014516-r59usk02 247 14 an an DT cord-014516-r59usk02 247 15 on on IN cord-014516-r59usk02 247 16 / / SYM cord-014516-r59usk02 247 17 off off IN cord-014516-r59usk02 247 18 switch switch NN cord-014516-r59usk02 247 19 . . . cord-014516-r59usk02 248 1 These these DT cord-014516-r59usk02 248 2 features feature NNS cord-014516-r59usk02 248 3 highlight highlight VBP cord-014516-r59usk02 248 4 the the DT cord-014516-r59usk02 248 5 potential potential NN cord-014516-r59usk02 248 6 of of IN cord-014516-r59usk02 248 7 miR miR NNP cord-014516-r59usk02 248 8 - - HYPH cord-014516-r59usk02 248 9 NAs NAs NNPS cord-014516-r59usk02 248 10 as as IN cord-014516-r59usk02 248 11 therapeutic therapeutic JJ cord-014516-r59usk02 248 12 targets target NNS cord-014516-r59usk02 248 13 . . . cord-014516-r59usk02 249 1 The the DT cord-014516-r59usk02 249 2 role role NN cord-014516-r59usk02 249 3 of of IN cord-014516-r59usk02 249 4 miRNAs miRNAs NNP cord-014516-r59usk02 249 5 in in IN cord-014516-r59usk02 249 6 myocardial myocardial JJ cord-014516-r59usk02 249 7 fibrosis fibrosis NN cord-014516-r59usk02 249 8 and and CC cord-014516-r59usk02 249 9 hypertrophic hypertrophic JJ cord-014516-r59usk02 249 10 cardiomyopathy cardiomyopathy NN cord-014516-r59usk02 249 11 has have VBZ cord-014516-r59usk02 249 12 been be VBN cord-014516-r59usk02 249 13 widely widely RB cord-014516-r59usk02 249 14 studied study VBN cord-014516-r59usk02 249 15 in in IN cord-014516-r59usk02 249 16 human human JJ cord-014516-r59usk02 249 17 patients patient NNS cord-014516-r59usk02 249 18 . . . cord-014516-r59usk02 250 1 However however RB cord-014516-r59usk02 250 2 , , , cord-014516-r59usk02 250 3 there there EX cord-014516-r59usk02 250 4 is be VBZ cord-014516-r59usk02 250 5 no no DT cord-014516-r59usk02 250 6 data datum NNS cord-014516-r59usk02 250 7 available available JJ cord-014516-r59usk02 250 8 for for IN cord-014516-r59usk02 250 9 canine canine JJ cord-014516-r59usk02 250 10 and and CC cord-014516-r59usk02 250 11 human human JJ cord-014516-r59usk02 250 12 myxomatous myxomatous JJ cord-014516-r59usk02 250 13 mitral mitral JJ cord-014516-r59usk02 250 14 valve valve NN cord-014516-r59usk02 250 15 disease disease NN cord-014516-r59usk02 250 16 ( ( -LRB- cord-014516-r59usk02 250 17 MMVD MMVD NNP cord-014516-r59usk02 250 18 ) ) -RRB- cord-014516-r59usk02 250 19 . . . cord-014516-r59usk02 251 1 The the DT cord-014516-r59usk02 251 2 aim aim NN cord-014516-r59usk02 251 3 of of IN cord-014516-r59usk02 251 4 this this DT cord-014516-r59usk02 251 5 study study NN cord-014516-r59usk02 251 6 was be VBD cord-014516-r59usk02 251 7 to to TO cord-014516-r59usk02 251 8 investigate investigate VB cord-014516-r59usk02 251 9 miRNA miRNA NNP cord-014516-r59usk02 251 10 transcriptomics transcriptomic NNS cord-014516-r59usk02 251 11 in in IN cord-014516-r59usk02 251 12 canine canine JJ cord-014516-r59usk02 251 13 MMVD MMVD NNP cord-014516-r59usk02 251 14 by by IN cord-014516-r59usk02 251 15 using use VBG cord-014516-r59usk02 251 16 global global JJ cord-014516-r59usk02 251 17 transcriptional transcriptional JJ cord-014516-r59usk02 251 18 profiling profiling NN cord-014516-r59usk02 251 19 , , , cord-014516-r59usk02 251 20 miRNA miRNA NNP cord-014516-r59usk02 251 21 target target VB cord-014516-r59usk02 251 22 prediction prediction NN cord-014516-r59usk02 251 23 software software NN cord-014516-r59usk02 251 24 ( ( -LRB- cord-014516-r59usk02 251 25 DIANA DIANA NNP cord-014516-r59usk02 251 26 Tool Tool NNP cord-014516-r59usk02 251 27 , , , cord-014516-r59usk02 251 28 TargetScan TargetScan NNP cord-014516-r59usk02 251 29 6.2 6.2 CD cord-014516-r59usk02 251 30 ) ) -RRB- cord-014516-r59usk02 251 31 and and CC cord-014516-r59usk02 251 32 network network NN cord-014516-r59usk02 251 33 analysis analysis NN cord-014516-r59usk02 251 34 software software NN cord-014516-r59usk02 251 35 ( ( -LRB- cord-014516-r59usk02 251 36 BioLayout BioLayout NNP cord-014516-r59usk02 251 37 Express Express NNP cord-014516-r59usk02 251 38 3D 3D NNP cord-014516-r59usk02 251 39 ) ) -RRB- cord-014516-r59usk02 251 40 . . . cord-014516-r59usk02 252 1 Four four CD cord-014516-r59usk02 252 2 myxomatous myxomatous JJ cord-014516-r59usk02 252 3 mitral mitral JJ cord-014516-r59usk02 252 4 valves valve NNS cord-014516-r59usk02 252 5 ( ( -LRB- cord-014516-r59usk02 252 6 CKCS CKCS NNP cord-014516-r59usk02 252 7 ) ) -RRB- cord-014516-r59usk02 252 8 and and CC cord-014516-r59usk02 252 9 4 4 CD cord-014516-r59usk02 252 10 controls control NNS cord-014516-r59usk02 252 11 valves valve NNS cord-014516-r59usk02 252 12 were be VBD cord-014516-r59usk02 252 13 profiled profile VBN cord-014516-r59usk02 252 14 using use VBG cord-014516-r59usk02 252 15 the the DT cord-014516-r59usk02 252 16 Affymetrix Affymetrix NNP cord-014516-r59usk02 252 17 Canine Canine NNP cord-014516-r59usk02 252 18 Gene Gene NNP cord-014516-r59usk02 252 19 1.0 1.0 CD cord-014516-r59usk02 252 20 ST ST NNP cord-014516-r59usk02 252 21 Array Array NNP cord-014516-r59usk02 252 22 . . . cord-014516-r59usk02 253 1 In in IN cord-014516-r59usk02 253 2 total total JJ cord-014516-r59usk02 253 3 29 29 CD cord-014516-r59usk02 253 4 out out IN cord-014516-r59usk02 253 5 of of IN cord-014516-r59usk02 253 6 302 302 CD cord-014516-r59usk02 253 7 miRNAs mirna NNS cord-014516-r59usk02 253 8 were be VBD cord-014516-r59usk02 253 9 found find VBN cord-014516-r59usk02 253 10 to to TO cord-014516-r59usk02 253 11 be be VB cord-014516-r59usk02 253 12 statistically statistically RB cord-014516-r59usk02 253 13 significantly significantly RB cord-014516-r59usk02 253 14 differentially differentially RB cord-014516-r59usk02 253 15 expressed express VBN cord-014516-r59usk02 253 16 ( ( -LRB- cord-014516-r59usk02 253 17 down down RB cord-014516-r59usk02 253 18 - - HYPH cord-014516-r59usk02 253 19 regulated regulate VBN cord-014516-r59usk02 253 20 ) ) -RRB- cord-014516-r59usk02 253 21 based base VBN cord-014516-r59usk02 253 22 on on IN cord-014516-r59usk02 253 23 the the DT cord-014516-r59usk02 253 24 false false JJ cord-014516-r59usk02 253 25 discovery discovery NN cord-014516-r59usk02 253 26 rate rate NN cord-014516-r59usk02 253 27 , , , cord-014516-r59usk02 253 28 p p NN cord-014516-r59usk02 253 29 - - HYPH cord-014516-r59usk02 253 30 value value NN cord-014516-r59usk02 253 31 , , , cord-014516-r59usk02 253 32 and and CC cord-014516-r59usk02 253 33 fold fold VB cord-014516-r59usk02 253 34 - - HYPH cord-014516-r59usk02 253 35 change change NN cord-014516-r59usk02 253 36 . . . cord-014516-r59usk02 254 1 Expression expression NN cord-014516-r59usk02 254 2 of of IN cord-014516-r59usk02 254 3 three three CD cord-014516-r59usk02 254 4 miRNA miRNA NNP cord-014516-r59usk02 254 5 ( ( -LRB- cord-014516-r59usk02 254 6 cfa cfa NNP cord-014516-r59usk02 254 7 - - HYPH cord-014516-r59usk02 254 8 miR-23b miR-23b NNP cord-014516-r59usk02 254 9 , , , cord-014516-r59usk02 254 10 cfa cfa NNP cord-014516-r59usk02 254 11 - - HYPH cord-014516-r59usk02 254 12 miR-29c miR-29c NNP cord-014516-r59usk02 254 13 , , , cord-014516-r59usk02 254 14 cfa cfa NNP cord-014516-r59usk02 254 15 - - HYPH cord-014516-r59usk02 254 16 miR-218 miR-218 NNP cord-014516-r59usk02 254 17 ) ) -RRB- cord-014516-r59usk02 254 18 were be VBD cord-014516-r59usk02 254 19 also also RB cord-014516-r59usk02 254 20 validated validate VBN cord-014516-r59usk02 254 21 by by IN cord-014516-r59usk02 254 22 quantitative quantitative JJ cord-014516-r59usk02 254 23 polymerase polymerase NN cord-014516-r59usk02 254 24 chain chain NN cord-014516-r59usk02 254 25 reaction reaction NN cord-014516-r59usk02 254 26 ( ( -LRB- cord-014516-r59usk02 254 27 Q Q NNP cord-014516-r59usk02 254 28 - - HYPH cord-014516-r59usk02 254 29 PCR PCR NNP cord-014516-r59usk02 254 30 , , , cord-014516-r59usk02 254 31 TaqMan TaqMan NNP cord-014516-r59usk02 254 32 ) ) -RRB- cord-014516-r59usk02 254 33 , , , cord-014516-r59usk02 254 34 and and CC cord-014516-r59usk02 254 35 the the DT cord-014516-r59usk02 254 36 results result NNS cord-014516-r59usk02 254 37 were be VBD cord-014516-r59usk02 254 38 in in IN cord-014516-r59usk02 254 39 agreement agreement NN cord-014516-r59usk02 254 40 with with IN cord-014516-r59usk02 254 41 the the DT cord-014516-r59usk02 254 42 microarray microarray NN cord-014516-r59usk02 254 43 findings finding NNS cord-014516-r59usk02 254 44 . . . cord-014516-r59usk02 255 1 For for IN cord-014516-r59usk02 255 2 network network NN cord-014516-r59usk02 255 3 analysis analysis NN cord-014516-r59usk02 255 4 and and CC cord-014516-r59usk02 255 5 visualization visualization NN cord-014516-r59usk02 255 6 , , , cord-014516-r59usk02 255 7 Markov Markov NNP cord-014516-r59usk02 255 8 clustering clustering NN cord-014516-r59usk02 255 9 algorithms algorithm NNS cord-014516-r59usk02 255 10 were be VBD cord-014516-r59usk02 255 11 conducted conduct VBN cord-014516-r59usk02 255 12 in in IN cord-014516-r59usk02 255 13 Bio Bio NNP cord-014516-r59usk02 255 14 - - HYPH cord-014516-r59usk02 255 15 Layout Layout NNP cord-014516-r59usk02 255 16 Express Express NNP cord-014516-r59usk02 255 17 3D 3d NN cord-014516-r59usk02 255 18 , , , cord-014516-r59usk02 255 19 and and CC cord-014516-r59usk02 255 20 major major JJ cord-014516-r59usk02 255 21 clusters cluster NNS cord-014516-r59usk02 255 22 of of IN cord-014516-r59usk02 255 23 miRNAs miRNAs NNP cord-014516-r59usk02 255 24 were be VBD cord-014516-r59usk02 255 25 exported export VBN cord-014516-r59usk02 255 26 and and CC cord-014516-r59usk02 255 27 uploaded upload VBN cord-014516-r59usk02 255 28 to to IN cord-014516-r59usk02 255 29 the the DT cord-014516-r59usk02 255 30 DIANA DIANA NNP cord-014516-r59usk02 255 31 - - HYPH cord-014516-r59usk02 255 32 miRPath miRPath NNP cord-014516-r59usk02 255 33 ( ( -LRB- cord-014516-r59usk02 255 34 KEGG KEGG NNP cord-014516-r59usk02 255 35 pathway pathway NN cord-014516-r59usk02 255 36 ) ) -RRB- cord-014516-r59usk02 255 37 web web NN cord-014516-r59usk02 255 38 - - HYPH cord-014516-r59usk02 255 39 server server NN cord-014516-r59usk02 255 40 . . . cord-014516-r59usk02 256 1 The the DT cord-014516-r59usk02 256 2 pathways pathway NNS cord-014516-r59usk02 256 3 identified identify VBN cord-014516-r59usk02 256 4 in in IN cord-014516-r59usk02 256 5 the the DT cord-014516-r59usk02 256 6 main main JJ cord-014516-r59usk02 256 7 cluster cluster NN cord-014516-r59usk02 256 8 were be VBD cord-014516-r59usk02 256 9 attributed attribute VBN cord-014516-r59usk02 256 10 to to IN cord-014516-r59usk02 256 11 the the DT cord-014516-r59usk02 256 12 biological biological JJ cord-014516-r59usk02 256 13 functions function NNS cord-014516-r59usk02 256 14 of of IN cord-014516-r59usk02 256 15 focal focal JJ cord-014516-r59usk02 256 16 adhesion adhesion NN cord-014516-r59usk02 256 17 , , , cord-014516-r59usk02 256 18 cytoskeleton cytoskeleton NN cord-014516-r59usk02 256 19 ( ( -LRB- cord-014516-r59usk02 256 20 actin actin NN cord-014516-r59usk02 256 21 ) ) -RRB- cord-014516-r59usk02 256 22 regulation regulation NN cord-014516-r59usk02 256 23 , , , cord-014516-r59usk02 256 24 TGF TGF NNP cord-014516-r59usk02 256 25 - - HYPH cord-014516-r59usk02 256 26 b b NN cord-014516-r59usk02 256 27 signalling signalling NN cord-014516-r59usk02 256 28 , , , cord-014516-r59usk02 256 29 glycosaminoglycan glycosaminoglycan NNP cord-014516-r59usk02 256 30 biosynthesis biosynthesis NN cord-014516-r59usk02 256 31 , , , cord-014516-r59usk02 256 32 osteoclast osteoclast JJ cord-014516-r59usk02 256 33 differentiation differentiation NN cord-014516-r59usk02 256 34 , , , cord-014516-r59usk02 256 35 NOTCH notch NN cord-014516-r59usk02 256 36 signalling signal VBG cord-014516-r59usk02 256 37 and and CC cord-014516-r59usk02 256 38 VEGF VEGF NNP cord-014516-r59usk02 256 39 signalling signal VBG cord-014516-r59usk02 256 40 . . . cord-014516-r59usk02 257 1 The the DT cord-014516-r59usk02 257 2 most most RBS cord-014516-r59usk02 257 3 significantly significantly RB cord-014516-r59usk02 257 4 down down RB cord-014516-r59usk02 257 5 - - HYPH cord-014516-r59usk02 257 6 regulated regulate VBN cord-014516-r59usk02 257 7 miRNA miRNA NNP cord-014516-r59usk02 257 8 in in IN cord-014516-r59usk02 257 9 MMVD MMVD NNP cord-014516-r59usk02 257 10 was be VBD cord-014516-r59usk02 257 11 cfa cfa NNP cord-014516-r59usk02 257 12 - - HYPH cord-014516-r59usk02 257 13 miR-218 miR-218 NNP cord-014516-r59usk02 257 14 , , , cord-014516-r59usk02 257 15 which which WDT cord-014516-r59usk02 257 16 is be VBZ cord-014516-r59usk02 257 17 an an DT cord-014516-r59usk02 257 18 endothelial endothelial JJ cord-014516-r59usk02 257 19 specific specific JJ cord-014516-r59usk02 257 20 miRNA mirna NN cord-014516-r59usk02 257 21 shown show VBN cord-014516-r59usk02 257 22 to to TO cord-014516-r59usk02 257 23 regulate regulate VB cord-014516-r59usk02 257 24 endothelial endothelial JJ cord-014516-r59usk02 257 25 migration migration NN cord-014516-r59usk02 257 26 and and CC cord-014516-r59usk02 257 27 vessel vessel NN cord-014516-r59usk02 257 28 patterning patterning NN cord-014516-r59usk02 257 29 . . . cord-014516-r59usk02 258 1 The the DT cord-014516-r59usk02 258 2 top top JJ cord-014516-r59usk02 258 3 predicted predict VBN cord-014516-r59usk02 258 4 target target NN cord-014516-r59usk02 258 5 of of IN cord-014516-r59usk02 258 6 cfa cfa NNP cord-014516-r59usk02 258 7 - - HYPH cord-014516-r59usk02 258 8 miR-218is miR-218is NNP cord-014516-r59usk02 258 9 glucuronic glucuronic NNP cord-014516-r59usk02 258 10 acid acid NN cord-014516-r59usk02 258 11 epimerase epimerase NN cord-014516-r59usk02 258 12 ( ( -LRB- cord-014516-r59usk02 258 13 GLCE GLCE NNP cord-014516-r59usk02 258 14 ) ) -RRB- cord-014516-r59usk02 258 15 which which WDT cord-014516-r59usk02 258 16 is be VBZ cord-014516-r59usk02 258 17 the the DT cord-014516-r59usk02 258 18 main main JJ cord-014516-r59usk02 258 19 enzyme enzyme NN cord-014516-r59usk02 258 20 controlling control VBG cord-014516-r59usk02 258 21 heparan heparan NN cord-014516-r59usk02 258 22 sulphate sulphate NN cord-014516-r59usk02 258 23 biosynthesis biosynthesis NN cord-014516-r59usk02 258 24 . . . cord-014516-r59usk02 259 1 Other other JJ cord-014516-r59usk02 259 2 interesting interesting JJ cord-014516-r59usk02 259 3 findings finding NNS cord-014516-r59usk02 259 4 were be VBD cord-014516-r59usk02 259 5 down down JJ cord-014516-r59usk02 259 6 - - HYPH cord-014516-r59usk02 259 7 regulation regulation NN cord-014516-r59usk02 259 8 of of IN cord-014516-r59usk02 259 9 cfa cfa NNP cord-014516-r59usk02 259 10 - - HYPH cord-014516-r59usk02 259 11 miR-29 miR-29 NNP cord-014516-r59usk02 259 12 and and CC cord-014516-r59usk02 259 13 members member NNS cord-014516-r59usk02 259 14 of of IN cord-014516-r59usk02 259 15 the the DT cord-014516-r59usk02 259 16 cfa cfa NNP cord-014516-r59usk02 259 17 - - HYPH cord-014516-r59usk02 259 18 miR-23 miR-23 NNP cord-014516-r59usk02 259 19 family family NN cord-014516-r59usk02 259 20 . . . cord-014516-r59usk02 260 1 Cfa Cfa NNP cord-014516-r59usk02 260 2 - - HYPH cord-014516-r59usk02 260 3 miR-29 miR-29 NNP cord-014516-r59usk02 260 4 targets target NNS cord-014516-r59usk02 260 5 multiple multiple JJ cord-014516-r59usk02 260 6 extracellular extracellular JJ cord-014516-r59usk02 260 7 matrix matrix NN cord-014516-r59usk02 260 8 transcripts transcript NNS cord-014516-r59usk02 260 9 , , , cord-014516-r59usk02 260 10 such such JJ cord-014516-r59usk02 260 11 as as IN cord-014516-r59usk02 260 12 collagens collagen NNS cord-014516-r59usk02 260 13 , , , cord-014516-r59usk02 260 14 elastin elastin NN cord-014516-r59usk02 260 15 , , , cord-014516-r59usk02 260 16 integrin integrin NN cord-014516-r59usk02 260 17 , , , cord-014516-r59usk02 260 18 laminin laminin NN cord-014516-r59usk02 260 19 , , , cord-014516-r59usk02 260 20 MMP MMP NNP cord-014516-r59usk02 260 21 ( ( -LRB- cord-014516-r59usk02 260 22 matrix matrix NN cord-014516-r59usk02 260 23 metalloproteinase metalloproteinase NN cord-014516-r59usk02 260 24 ) ) -RRB- cord-014516-r59usk02 260 25 and and CC cord-014516-r59usk02 260 26 ADAMTS ADAMTS NNP cord-014516-r59usk02 260 27 ( ( -LRB- cord-014516-r59usk02 260 28 a a DT cord-014516-r59usk02 260 29 disintegrin disintegrin NN cord-014516-r59usk02 260 30 and and CC cord-014516-r59usk02 260 31 metalloproteinase metalloproteinase NN cord-014516-r59usk02 260 32 with with IN cord-014516-r59usk02 260 33 thrombospondin thrombospondin NNP cord-014516-r59usk02 260 34 motifs motifs NNP cord-014516-r59usk02 260 35 ) ) -RRB- cord-014516-r59usk02 260 36 , , , cord-014516-r59usk02 260 37 whereas whereas IN cord-014516-r59usk02 260 38 cfa cfa NNP cord-014516-r59usk02 260 39 - - HYPH cord-014516-r59usk02 260 40 miR-23 miR-23 NNP cord-014516-r59usk02 260 41 targets target NNS cord-014516-r59usk02 260 42 hyaluronic hyaluronic NN cord-014516-r59usk02 260 43 acid acid NN cord-014516-r59usk02 260 44 synthase synthase NN cord-014516-r59usk02 260 45 2 2 CD cord-014516-r59usk02 260 46 ( ( -LRB- cord-014516-r59usk02 260 47 Has2 Has2 NNP cord-014516-r59usk02 260 48 ) ) -RRB- cord-014516-r59usk02 260 49 . . . cord-014516-r59usk02 261 1 Since since IN cord-014516-r59usk02 261 2 the the DT cord-014516-r59usk02 261 3 major major JJ cord-014516-r59usk02 261 4 pathology pathology NN cord-014516-r59usk02 261 5 of of IN cord-014516-r59usk02 261 6 MMVD MMVD NNP cord-014516-r59usk02 261 7 is be VBZ cord-014516-r59usk02 261 8 aberrant aberrant JJ cord-014516-r59usk02 261 9 turnover turnover NN cord-014516-r59usk02 261 10 of of IN cord-014516-r59usk02 261 11 extracellular extracellular JJ cord-014516-r59usk02 261 12 matrix matrix NN cord-014516-r59usk02 261 13 proteins protein NNS cord-014516-r59usk02 261 14 , , , cord-014516-r59usk02 261 15 this this DT cord-014516-r59usk02 261 16 may may MD cord-014516-r59usk02 261 17 be be VB cord-014516-r59usk02 261 18 linked link VBN cord-014516-r59usk02 261 19 to to IN cord-014516-r59usk02 261 20 miR miR NNP cord-014516-r59usk02 261 21 - - HYPH cord-014516-r59usk02 261 22 NA NA NNP cord-014516-r59usk02 261 23 regulation regulation NN cord-014516-r59usk02 261 24 . . . cord-014516-r59usk02 262 1 Dysregulation dysregulation NN cord-014516-r59usk02 262 2 of of IN cord-014516-r59usk02 262 3 valve valve NN cord-014516-r59usk02 262 4 miRNAs miRNAs NNP cord-014516-r59usk02 262 5 might may MD cord-014516-r59usk02 262 6 be be VB cord-014516-r59usk02 262 7 potential potential JJ cord-014516-r59usk02 262 8 therapeutic therapeutic JJ cord-014516-r59usk02 262 9 targets target NNS cord-014516-r59usk02 262 10 in in IN cord-014516-r59usk02 262 11 the the DT cord-014516-r59usk02 262 12 treatment treatment NN cord-014516-r59usk02 262 13 of of IN cord-014516-r59usk02 262 14 canine canine JJ cord-014516-r59usk02 262 15 MMVD MMVD NNP cord-014516-r59usk02 262 16 . . . cord-014516-r59usk02 263 1 No no DT cord-014516-r59usk02 263 2 conflicts conflict NNS cord-014516-r59usk02 263 3 of of IN cord-014516-r59usk02 263 4 interest interest NN cord-014516-r59usk02 263 5 reported report VBN cord-014516-r59usk02 263 6 . . . cord-014516-r59usk02 264 1 Mitral mitral JJ cord-014516-r59usk02 264 2 regurgitation regurgitation NN cord-014516-r59usk02 264 3 ( ( -LRB- cord-014516-r59usk02 264 4 MR MR NNP cord-014516-r59usk02 264 5 ) ) -RRB- cord-014516-r59usk02 264 6 progresses progress VBZ cord-014516-r59usk02 264 7 slowly slowly RB cord-014516-r59usk02 264 8 , , , cord-014516-r59usk02 264 9 but but CC cord-014516-r59usk02 264 10 dogs dog NNS cord-014516-r59usk02 264 11 living live VBG cord-014516-r59usk02 264 12 long long RB cord-014516-r59usk02 264 13 enough enough RB cord-014516-r59usk02 264 14 often often RB cord-014516-r59usk02 264 15 develop develop VB cord-014516-r59usk02 264 16 congestive congestive JJ cord-014516-r59usk02 264 17 heart heart NN cord-014516-r59usk02 264 18 failure failure NN cord-014516-r59usk02 264 19 ( ( -LRB- cord-014516-r59usk02 264 20 CHF CHF NNP cord-014516-r59usk02 264 21 ) ) -RRB- cord-014516-r59usk02 264 22 . . . cord-014516-r59usk02 265 1 However however RB cord-014516-r59usk02 265 2 , , , cord-014516-r59usk02 265 3 tools tool NNS cord-014516-r59usk02 265 4 to to TO cord-014516-r59usk02 265 5 predict predict VB cord-014516-r59usk02 265 6 onset onset NN cord-014516-r59usk02 265 7 of of IN cord-014516-r59usk02 265 8 CHF CHF NNP cord-014516-r59usk02 265 9 are be VBP cord-014516-r59usk02 265 10 sparse sparse JJ cord-014516-r59usk02 265 11 . . . cord-014516-r59usk02 266 1 225 225 CD cord-014516-r59usk02 266 2 echocardiographic echocardiographic JJ cord-014516-r59usk02 266 3 examinations examination NNS cord-014516-r59usk02 266 4 in in IN cord-014516-r59usk02 266 5 78 78 CD cord-014516-r59usk02 266 6 dogs dog NNS cord-014516-r59usk02 266 7 were be VBD cord-014516-r59usk02 266 8 performed perform VBN cord-014516-r59usk02 266 9 in in IN cord-014516-r59usk02 266 10 a a DT cord-014516-r59usk02 266 11 longitudinal longitudinal JJ cord-014516-r59usk02 266 12 , , , cord-014516-r59usk02 266 13 multicenter multicenter JJ cord-014516-r59usk02 266 14 study study NN cord-014516-r59usk02 266 15 with with IN cord-014516-r59usk02 266 16 a a DT cord-014516-r59usk02 266 17 surveillance surveillance NN cord-014516-r59usk02 266 18 time time NN cord-014516-r59usk02 266 19 of of IN cord-014516-r59usk02 266 20 up up IN cord-014516-r59usk02 266 21 to to TO cord-014516-r59usk02 266 22 4.5 4.5 CD cord-014516-r59usk02 266 23 years year NNS cord-014516-r59usk02 266 24 . . . cord-014516-r59usk02 267 1 Client client NN cord-014516-r59usk02 267 2 - - HYPH cord-014516-r59usk02 267 3 owned own VBN cord-014516-r59usk02 267 4 dogswere dogswere NN cord-014516-r59usk02 267 5 enrolled enrol VBN cord-014516-r59usk02 267 6 at at IN cord-014516-r59usk02 267 7 the the DT cord-014516-r59usk02 267 8 University University NNP cord-014516-r59usk02 267 9 Hospitals Hospitals NNPS cord-014516-r59usk02 267 10 in in IN cord-014516-r59usk02 267 11 Finland Finland NNP cord-014516-r59usk02 267 12 , , , cord-014516-r59usk02 267 13 Sweden Sweden NNP cord-014516-r59usk02 267 14 and and CC cord-014516-r59usk02 267 15 Denmark Denmark NNP cord-014516-r59usk02 267 16 ( ( -LRB- cord-014516-r59usk02 267 17 subset subset VBN cord-014516-r59usk02 267 18 to to IN cord-014516-r59usk02 267 19 the the DT cord-014516-r59usk02 267 20 SVEP SVEP NNP cord-014516-r59usk02 267 21 study study NN cord-014516-r59usk02 267 22 ) ) -RRB- cord-014516-r59usk02 267 23 . . . cord-014516-r59usk02 268 1 Left leave VBN cord-014516-r59usk02 268 2 ventricular ventricular JJ cord-014516-r59usk02 268 3 end end NN cord-014516-r59usk02 268 4 diastolic diastolic JJ cord-014516-r59usk02 268 5 ( ( -LRB- cord-014516-r59usk02 268 6 LVIDd LVIDd NNP cord-014516-r59usk02 268 7 ) ) -RRB- cord-014516-r59usk02 268 8 and and CC cord-014516-r59usk02 268 9 systolic systolic JJ cord-014516-r59usk02 268 10 ( ( -LRB- cord-014516-r59usk02 268 11 LVIDs lvid NNS cord-014516-r59usk02 268 12 ) ) -RRB- cord-014516-r59usk02 268 13 diameters diameter NNS cord-014516-r59usk02 268 14 , , , cord-014516-r59usk02 268 15 fractional fractional JJ cord-014516-r59usk02 268 16 shortening shortening NN cord-014516-r59usk02 268 17 ( ( -LRB- cord-014516-r59usk02 268 18 FS FS NNP cord-014516-r59usk02 268 19 ) ) -RRB- cord-014516-r59usk02 268 20 , , , cord-014516-r59usk02 268 21 left leave VBN cord-014516-r59usk02 268 22 atrial atrial JJ cord-014516-r59usk02 268 23 ( ( -LRB- cord-014516-r59usk02 268 24 LA LA NNP cord-014516-r59usk02 268 25 ) ) -RRB- cord-014516-r59usk02 268 26 and and CC cord-014516-r59usk02 268 27 aortic aortic JJ cord-014516-r59usk02 268 28 root root NN cord-014516-r59usk02 268 29 ( ( -LRB- cord-014516-r59usk02 268 30 Ao ao NN cord-014516-r59usk02 268 31 ) ) -RRB- cord-014516-r59usk02 268 32 diameters diameter NNS cord-014516-r59usk02 268 33 were be VBD cord-014516-r59usk02 268 34 estimated estimate VBN cord-014516-r59usk02 268 35 . . . cord-014516-r59usk02 269 1 Values value NNS cord-014516-r59usk02 269 2 were be VBD cord-014516-r59usk02 269 3 normalized normalize VBN cord-014516-r59usk02 269 4 for for IN cord-014516-r59usk02 269 5 body body NN cord-014516-r59usk02 269 6 size size NN cord-014516-r59usk02 269 7 ( ( -LRB- cord-014516-r59usk02 269 8 nLVIDd nLVIDd NNP cord-014516-r59usk02 269 9 , , , cord-014516-r59usk02 269 10 nLVIDs nLVIDs NNP cord-014516-r59usk02 269 11 , , , cord-014516-r59usk02 269 12 and and CC cord-014516-r59usk02 269 13 nLA nLA NNP cord-014516-r59usk02 269 14 , , , cord-014516-r59usk02 269 15 respectively respectively RB cord-014516-r59usk02 269 16 ) ) -RRB- cord-014516-r59usk02 269 17 and and CC cord-014516-r59usk02 269 18 , , , cord-014516-r59usk02 269 19 for for IN cord-014516-r59usk02 269 20 comparison comparison NN cord-014516-r59usk02 269 21 , , , cord-014516-r59usk02 269 22 ratios ratio NNS cord-014516-r59usk02 269 23 to to IN cord-014516-r59usk02 269 24 aortic aortic JJ cord-014516-r59usk02 269 25 root root NN cord-014516-r59usk02 269 26 were be VBD cord-014516-r59usk02 269 27 calculated calculate VBN cord-014516-r59usk02 270 1 ( ( -LRB- cord-014516-r59usk02 270 2 LVIDd LVIDd NNP cord-014516-r59usk02 270 3 / / SYM cord-014516-r59usk02 270 4 Ao Ao NNP cord-014516-r59usk02 270 5 , , , cord-014516-r59usk02 270 6 LVIDs LVIDs NNP cord-014516-r59usk02 270 7 / / SYM cord-014516-r59usk02 270 8 Ao Ao NNP cord-014516-r59usk02 270 9 and and CC cord-014516-r59usk02 270 10 LA LA NNP cord-014516-r59usk02 270 11 / / SYM cord-014516-r59usk02 270 12 Ao Ao NNP cord-014516-r59usk02 270 13 , , , cord-014516-r59usk02 270 14 respectively respectively RB cord-014516-r59usk02 270 15 ) ) -RRB- cord-014516-r59usk02 270 16 . . . cord-014516-r59usk02 271 1 A a DT cord-014516-r59usk02 271 2 Cox Cox NNP cord-014516-r59usk02 271 3 's 's POS cord-014516-r59usk02 271 4 proportional proportional JJ cord-014516-r59usk02 271 5 hazard hazard NN cord-014516-r59usk02 271 6 analysis analysis NN cord-014516-r59usk02 271 7 with with IN cord-014516-r59usk02 271 8 a a DT cord-014516-r59usk02 271 9 counting counting NN cord-014516-r59usk02 271 10 process process NN cord-014516-r59usk02 271 11 approach approach NN cord-014516-r59usk02 271 12 was be VBD cord-014516-r59usk02 271 13 used use VBN cord-014516-r59usk02 271 14 . . . cord-014516-r59usk02 272 1 Spline spline NN cord-014516-r59usk02 272 2 smoothed smooth VBD cord-014516-r59usk02 272 3 graphical graphical JJ cord-014516-r59usk02 272 4 models model NNS cord-014516-r59usk02 272 5 were be VBD cord-014516-r59usk02 272 6 constructed construct VBN cord-014516-r59usk02 272 7 to to TO cord-014516-r59usk02 272 8 evaluate evaluate VB cord-014516-r59usk02 272 9 linearity linearity NN cord-014516-r59usk02 272 10 of of IN cord-014516-r59usk02 272 11 hazards hazard NNS cord-014516-r59usk02 272 12 . . . cord-014516-r59usk02 273 1 Curves curve NNS cord-014516-r59usk02 273 2 were be VBD cord-014516-r59usk02 273 3 then then RB cord-014516-r59usk02 273 4 used use VBN cord-014516-r59usk02 273 5 to to TO cord-014516-r59usk02 273 6 find find VB cord-014516-r59usk02 273 7 cut cut VBN cord-014516-r59usk02 273 8 - - HYPH cord-014516-r59usk02 273 9 off off RP cord-014516-r59usk02 273 10 values value NNS cord-014516-r59usk02 273 11 for for IN cord-014516-r59usk02 273 12 interval interval NN cord-014516-r59usk02 273 13 hazard hazard NN cord-014516-r59usk02 273 14 ratios ratio NNS cord-014516-r59usk02 273 15 ( ( -LRB- cord-014516-r59usk02 273 16 HRs hr NNS cord-014516-r59usk02 273 17 ) ) -RRB- cord-014516-r59usk02 273 18 . . . cord-014516-r59usk02 274 1 The the DT cord-014516-r59usk02 274 2 HR HR NNP cord-014516-r59usk02 274 3 for for IN cord-014516-r59usk02 274 4 nLVIDd nlvidd NN cord-014516-r59usk02 274 5 , , , cord-014516-r59usk02 274 6 nLVIDs nLVIDs NNP cord-014516-r59usk02 274 7 and and CC cord-014516-r59usk02 274 8 nLA nLA NNP cord-014516-r59usk02 274 9 ( ( -LRB- cord-014516-r59usk02 274 10 per per IN cord-014516-r59usk02 274 11 0.1 0.1 CD cord-014516-r59usk02 274 12 unit unit NN cord-014516-r59usk02 274 13 , , , cord-014516-r59usk02 274 14 95 95 CD cord-014516-r59usk02 274 15 % % NN cord-014516-r59usk02 274 16 confidence confidence NN cord-014516-r59usk02 274 17 intervals interval NNS cord-014516-r59usk02 274 18 ) ) -RRB- cord-014516-r59usk02 274 19 , , , cord-014516-r59usk02 274 20 were be VBD cord-014516-r59usk02 274 21 1.5 1.5 CD cord-014516-r59usk02 274 22 ( ( -LRB- cord-014516-r59usk02 274 23 1.32 1.32 CD cord-014516-r59usk02 274 24 - - SYM cord-014516-r59usk02 274 25 1.70 1.70 CD cord-014516-r59usk02 274 26 , , , cord-014516-r59usk02 274 27 p p NN cord-014516-r59usk02 274 28 = = SYM cord-014516-r59usk02 274 29 0.00034 0.00034 CD cord-014516-r59usk02 274 30 ) ) -RRB- cord-014516-r59usk02 274 31 , , , cord-014516-r59usk02 274 32 1.3 1.3 CD cord-014516-r59usk02 274 33 ( ( -LRB- cord-014516-r59usk02 274 34 1.05 1.05 CD cord-014516-r59usk02 274 35 - - SYM cord-014516-r59usk02 274 36 1.62 1.62 CD cord-014516-r59usk02 274 37 , , , cord-014516-r59usk02 274 38 p p NN cord-014516-r59usk02 274 39 = = SYM cord-014516-r59usk02 274 40 0.016 0.016 CD cord-014516-r59usk02 274 41 ) ) -RRB- cord-014516-r59usk02 274 42 , , , cord-014516-r59usk02 274 43 and and CC cord-014516-r59usk02 274 44 1.5 1.5 CD cord-014516-r59usk02 274 45 ( ( -LRB- cord-014516-r59usk02 274 46 1.28 1.28 CD cord-014516-r59usk02 274 47 - - SYM cord-014516-r59usk02 274 48 1.83 1.83 CD cord-014516-r59usk02 274 49 , , , cord-014516-r59usk02 274 50 p p NN cord-014516-r59usk02 274 51 = = SYM cord-014516-r59usk02 274 52 0.0039 0.0039 CD cord-014516-r59usk02 274 53 ) ) -RRB- cord-014516-r59usk02 274 54 , , , cord-014516-r59usk02 274 55 respectively respectively RB cord-014516-r59usk02 274 56 . . . cord-014516-r59usk02 275 1 The the DT cord-014516-r59usk02 275 2 HRs hr NNS cord-014516-r59usk02 275 3 for for IN cord-014516-r59usk02 275 4 LVIDd LVIDd NNS cord-014516-r59usk02 275 5 / / SYM cord-014516-r59usk02 275 6 Ao Ao NNP cord-014516-r59usk02 275 7 , , , cord-014516-r59usk02 275 8 LVIDs LVIDs NNP cord-014516-r59usk02 275 9 / / SYM cord-014516-r59usk02 275 10 Ao Ao NNP cord-014516-r59usk02 275 11 and and CC cord-014516-r59usk02 275 12 LA LA NNP cord-014516-r59usk02 275 13 / / SYM cord-014516-r59usk02 275 14 Ao Ao NNP cord-014516-r59usk02 275 15 ( ( -LRB- cord-014516-r59usk02 275 16 0.1 0.1 CD cord-014516-r59usk02 275 17 unit unit NN cord-014516-r59usk02 275 18 increase increase NN cord-014516-r59usk02 275 19 ) ) -RRB- cord-014516-r59usk02 275 20 were be VBD cord-014516-r59usk02 275 21 1.3 1.3 CD cord-014516-r59usk02 275 22 ( ( -LRB- cord-014516-r59usk02 275 23 1.14 1.14 CD cord-014516-r59usk02 275 24 - - SYM cord-014516-r59usk02 275 25 1.55 1.55 CD cord-014516-r59usk02 275 26 , , , cord-014516-r59usk02 275 27 p p NN cord-014516-r59usk02 275 28 = = SYM cord-014516-r59usk02 275 29 0.0025 0.0025 CD cord-014516-r59usk02 275 30 ) ) -RRB- cord-014516-r59usk02 275 31 , , , cord-014516-r59usk02 275 32 1.1 1.1 CD cord-014516-r59usk02 275 33 ( ( -LRB- cord-014516-r59usk02 275 34 0.99 0.99 CD cord-014516-r59usk02 275 35 - - SYM cord-014516-r59usk02 275 36 1.32 1.32 CD cord-014516-r59usk02 275 37 , , , cord-014516-r59usk02 275 38 p p NN cord-014516-r59usk02 275 39 = = SYM cord-014516-r59usk02 275 40 0.07 0.07 CD cord-014516-r59usk02 275 41 ) ) -RRB- cord-014516-r59usk02 275 42 , , , cord-014516-r59usk02 275 43 and and CC cord-014516-r59usk02 275 44 1.4 1.4 CD cord-014516-r59usk02 275 45 ( ( -LRB- cord-014516-r59usk02 275 46 1.24 1.24 CD cord-014516-r59usk02 275 47 - - SYM cord-014516-r59usk02 275 48 1.66 1.66 CD cord-014516-r59usk02 275 49 , , , cord-014516-r59usk02 275 50 p p NN cord-014516-r59usk02 275 51 = = SYM cord-014516-r59usk02 275 52 0.0041 0.0041 CD cord-014516-r59usk02 275 53 ) ) -RRB- cord-014516-r59usk02 275 54 , , , cord-014516-r59usk02 275 55 respectively respectively RB cord-014516-r59usk02 275 56 . . . cord-014516-r59usk02 276 1 The the DT cord-014516-r59usk02 276 2 HR HR NNP cord-014516-r59usk02 276 3 for for IN cord-014516-r59usk02 276 4 FS FS NNP cord-014516-r59usk02 276 5 was be VBD cord-014516-r59usk02 276 6 1.1 1.1 CD cord-014516-r59usk02 276 7 ( ( -LRB- cord-014516-r59usk02 276 8 1.05 1.05 CD cord-014516-r59usk02 276 9 - - SYM cord-014516-r59usk02 276 10 1.19 1.19 CD cord-014516-r59usk02 276 11 , , , cord-014516-r59usk02 276 12 p p NN cord-014516-r59usk02 276 13 = = SYM cord-014516-r59usk02 276 14 0.00037 0.00037 CD cord-014516-r59usk02 276 15 ) ) -RRB- cord-014516-r59usk02 276 16 . . . cord-014516-r59usk02 277 1 The the DT cord-014516-r59usk02 277 2 relative relative JJ cord-014516-r59usk02 277 3 hazard hazard NN cord-014516-r59usk02 277 4 plot plot NN cord-014516-r59usk02 277 5 presented present VBD cord-014516-r59usk02 277 6 a a DT cord-014516-r59usk02 277 7 steep steep JJ cord-014516-r59usk02 277 8 increase increase NN cord-014516-r59usk02 277 9 for for IN cord-014516-r59usk02 277 10 FS fs NN cord-014516-r59usk02 277 11 values value NNS cord-014516-r59usk02 277 12 above above IN cord-014516-r59usk02 277 13 31 31 CD cord-014516-r59usk02 277 14 % % NN cord-014516-r59usk02 277 15 . . . cord-014516-r59usk02 278 1 HRs hr NNS cord-014516-r59usk02 278 2 for for IN cord-014516-r59usk02 278 3 intervals interval NNS cord-014516-r59usk02 278 4 31 31 CD cord-014516-r59usk02 278 5 < < SYM cord-014516-r59usk02 278 6 36 36 CD cord-014516-r59usk02 278 7 % % NN cord-014516-r59usk02 278 8 , , , cord-014516-r59usk02 278 9 36 36 CD cord-014516-r59usk02 278 10 < < XX cord-014516-r59usk02 278 11 40 40 CD cord-014516-r59usk02 278 12 % % NN cord-014516-r59usk02 278 13 , , , cord-014516-r59usk02 278 14 and and CC cord-014516-r59usk02 278 15 ≥40 ≥40 NNP cord-014516-r59usk02 278 16 % % NN cord-014516-r59usk02 278 17 were be VBD cord-014516-r59usk02 278 18 1.0 1.0 CD cord-014516-r59usk02 278 19 ( ( -LRB- cord-014516-r59usk02 278 20 0.2 0.2 CD cord-014516-r59usk02 278 21 - - SYM cord-014516-r59usk02 278 22 5.1 5.1 CD cord-014516-r59usk02 278 23 , , , cord-014516-r59usk02 278 24 p p NN cord-014516-r59usk02 278 25 = = SYM cord-014516-r59usk02 278 26 0.99 0.99 CD cord-014516-r59usk02 278 27 ) ) -RRB- cord-014516-r59usk02 278 28 , , , cord-014516-r59usk02 278 29 4.8 4.8 CD cord-014516-r59usk02 278 30 ( ( -LRB- cord-014516-r59usk02 278 31 1.2 1.2 CD cord-014516-r59usk02 278 32 - - SYM cord-014516-r59usk02 278 33 18.4 18.4 CD cord-014516-r59usk02 278 34 , , , cord-014516-r59usk02 278 35 p p NN cord-014516-r59usk02 278 36 = = SYM cord-014516-r59usk02 278 37 0.023 0.023 CD cord-014516-r59usk02 278 38 ) ) -RRB- cord-014516-r59usk02 278 39 , , , cord-014516-r59usk02 278 40 and and CC cord-014516-r59usk02 278 41 9.1 9.1 CD cord-014516-r59usk02 278 42 ( ( -LRB- cord-014516-r59usk02 278 43 2.4 2.4 CD cord-014516-r59usk02 278 44 - - SYM cord-014516-r59usk02 278 45 33.7 33.7 CD cord-014516-r59usk02 278 46 , , , cord-014516-r59usk02 278 47 p p NN cord-014516-r59usk02 278 48 = = SYM cord-014516-r59usk02 278 49 0.00098 0.00098 CD cord-014516-r59usk02 278 50 ) ) -RRB- cord-014516-r59usk02 278 51 , , , cord-014516-r59usk02 278 52 respectively respectively RB cord-014516-r59usk02 278 53 . . . cord-014516-r59usk02 279 1 The the DT cord-014516-r59usk02 279 2 HR HR NNP cord-014516-r59usk02 279 3 for for IN cord-014516-r59usk02 279 4 nLVIDd nlvidd NN cord-014516-r59usk02 279 5 increased increase VBD cord-014516-r59usk02 279 6 linearly linearly RB cord-014516-r59usk02 279 7 . . . cord-014516-r59usk02 280 1 HRs hr NNS cord-014516-r59usk02 280 2 for for IN cord-014516-r59usk02 280 3 intervals interval NNS cord-014516-r59usk02 280 4 1.73 1.73 CD cord-014516-r59usk02 280 5 < < XX cord-014516-r59usk02 280 6 1.86 1.86 CD cord-014516-r59usk02 280 7 , , , cord-014516-r59usk02 280 8 1.86 1.86 CD cord-014516-r59usk02 280 9 < < XX cord-014516-r59usk02 280 10 1.92 1.92 CD cord-014516-r59usk02 280 11 , , , cord-014516-r59usk02 280 12 1.92 1.92 CD cord-014516-r59usk02 280 13 < < XX cord-014516-r59usk02 280 14 2.1 2.1 CD cord-014516-r59usk02 281 1 and and CC cord-014516-r59usk02 281 2 ≥2.1 ≥2.1 NNP cord-014516-r59usk02 281 3 were be VBD cord-014516-r59usk02 281 4 0.7 0.7 CD cord-014516-r59usk02 281 5 ( ( -LRB- cord-014516-r59usk02 281 6 0.1 0.1 CD cord-014516-r59usk02 281 7 - - SYM cord-014516-r59usk02 281 8 6.6 6.6 CD cord-014516-r59usk02 281 9 , , , cord-014516-r59usk02 281 10 p p NN cord-014516-r59usk02 281 11 = = SYM cord-014516-r59usk02 281 12 0.7 0.7 CD cord-014516-r59usk02 281 13 ) ) -RRB- cord-014516-r59usk02 281 14 , , , cord-014516-r59usk02 281 15 6.0 6.0 CD cord-014516-r59usk02 281 16 ( ( -LRB- cord-014516-r59usk02 281 17 1.3 1.3 CD cord-014516-r59usk02 281 18 - - SYM cord-014516-r59usk02 281 19 26.7 26.7 CD cord-014516-r59usk02 281 20 , , , cord-014516-r59usk02 281 21 p p NN cord-014516-r59usk02 281 22 = = SYM cord-014516-r59usk02 281 23 0.02 0.02 CD cord-014516-r59usk02 281 24 ) ) -RRB- cord-014516-r59usk02 281 25 , , , cord-014516-r59usk02 281 26 6.8 6.8 CD cord-014516-r59usk02 281 27 ( ( -LRB- cord-014516-r59usk02 281 28 1.9 1.9 CD cord-014516-r59usk02 281 29 - - SYM cord-014516-r59usk02 281 30 25.1 25.1 CD cord-014516-r59usk02 281 31 , , , cord-014516-r59usk02 281 32 p p NN cord-014516-r59usk02 281 33 = = SYM cord-014516-r59usk02 281 34 0.0037 0.0037 CD cord-014516-r59usk02 281 35 ) ) -RRB- cord-014516-r59usk02 281 36 , , , cord-014516-r59usk02 281 37 and and CC cord-014516-r59usk02 281 38 12.5 12.5 CD cord-014516-r59usk02 281 39 ( ( -LRB- cord-014516-r59usk02 281 40 3.8 3.8 CD cord-014516-r59usk02 281 41 - - SYM cord-014516-r59usk02 281 42 40.1 40.1 CD cord-014516-r59usk02 281 43 , , , cord-014516-r59usk02 281 44 p p NN cord-014516-r59usk02 281 45 = = SYM cord-014516-r59usk02 281 46 0.00088 0.00088 CD cord-014516-r59usk02 281 47 ) ) -RRB- cord-014516-r59usk02 281 48 , , , cord-014516-r59usk02 281 49 respectively respectively RB cord-014516-r59usk02 281 50 . . . cord-014516-r59usk02 282 1 In in IN cord-014516-r59usk02 282 2 contrast contrast NN cord-014516-r59usk02 282 3 , , , cord-014516-r59usk02 282 4 the the DT cord-014516-r59usk02 282 5 hazard hazard NN cord-014516-r59usk02 282 6 for for IN cord-014516-r59usk02 282 7 nLVIDs nLVIDs NNP cord-014516-r59usk02 282 8 remained remain VBN cord-014516-r59usk02 282 9 stable stable JJ cord-014516-r59usk02 282 10 until until IN cord-014516-r59usk02 282 11 1.4 1.4 CD cord-014516-r59usk02 282 12 , , , cord-014516-r59usk02 282 13 whereafter whereafter RBR cord-014516-r59usk02 282 14 it -PRON- PRP cord-014516-r59usk02 282 15 increased increase VBD cord-014516-r59usk02 282 16 . . . cord-014516-r59usk02 283 1 The the DT cord-014516-r59usk02 283 2 HRs hr NNS cord-014516-r59usk02 283 3 for for IN cord-014516-r59usk02 283 4 nLVIDs nlvids JJ cord-014516-r59usk02 283 5 ( ( -LRB- cord-014516-r59usk02 283 6 1 1 CD cord-014516-r59usk02 283 7 < < XX cord-014516-r59usk02 283 8 1.33 1.33 CD cord-014516-r59usk02 283 9 , , , cord-014516-r59usk02 283 10 1.33 1.33 CD cord-014516-r59usk02 283 11 < < XX cord-014516-r59usk02 283 12 1.68 1.68 CD cord-014516-r59usk02 283 13 , , , cord-014516-r59usk02 283 14 1.68 1.68 CD cord-014516-r59usk02 283 15 < < XX cord-014516-r59usk02 283 16 1.86 1.86 CD cord-014516-r59usk02 283 17 and and CC cord-014516-r59usk02 283 18 ≥1.86 ≥1.86 CD cord-014516-r59usk02 283 19 ) ) -RRB- cord-014516-r59usk02 283 20 were be VBD cord-014516-r59usk02 283 21 1.6 1.6 CD cord-014516-r59usk02 283 22 ( ( -LRB- cord-014516-r59usk02 283 23 0.6 0.6 CD cord-014516-r59usk02 283 24 - - SYM cord-014516-r59usk02 283 25 4.6 4.6 CD cord-014516-r59usk02 283 26 , , , cord-014516-r59usk02 283 27 p p NN cord-014516-r59usk02 283 28 = = SYM cord-014516-r59usk02 283 29 0.35 0.35 CD cord-014516-r59usk02 283 30 ) ) -RRB- cord-014516-r59usk02 283 31 , , , cord-014516-r59usk02 283 32 3.4 3.4 CD cord-014516-r59usk02 283 33 ( ( -LRB- cord-014516-r59usk02 283 34 1.0 1.0 CD cord-014516-r59usk02 283 35 - - SYM cord-014516-r59usk02 283 36 11.5 11.5 CD cord-014516-r59usk02 283 37 , , , cord-014516-r59usk02 283 38 p p NN cord-014516-r59usk02 283 39 = = SYM cord-014516-r59usk02 283 40 0.048 0.048 CD cord-014516-r59usk02 283 41 ) ) -RRB- cord-014516-r59usk02 283 42 , , , cord-014516-r59usk02 283 43 78 78 CD cord-014516-r59usk02 283 44 ( ( -LRB- cord-014516-r59usk02 283 45 9.6 9.6 CD cord-014516-r59usk02 283 46 - - SYM cord-014516-r59usk02 283 47 634 634 CD cord-014516-r59usk02 283 48 , , , cord-014516-r59usk02 283 49 p p NN cord-014516-r59usk02 283 50 = = SYM cord-014516-r59usk02 283 51 0.030 0.030 CD cord-014516-r59usk02 283 52 ) ) -RRB- cord-014516-r59usk02 283 53 , , , cord-014516-r59usk02 283 54 and and CC cord-014516-r59usk02 283 55 47.6 47.6 CD cord-014516-r59usk02 283 56 ( ( -LRB- cord-014516-r59usk02 283 57 7.1 7.1 CD cord-014516-r59usk02 283 58 - - SYM cord-014516-r59usk02 283 59 316 316 CD cord-014516-r59usk02 283 60 , , , cord-014516-r59usk02 283 61 p p NN cord-014516-r59usk02 283 62 = = SYM cord-014516-r59usk02 283 63 0.044 0.044 CD cord-014516-r59usk02 283 64 ) ) -RRB- cord-014516-r59usk02 283 65 , , , cord-014516-r59usk02 283 66 respectively respectively RB cord-014516-r59usk02 283 67 . . . cord-014516-r59usk02 284 1 HRs hr NNS cord-014516-r59usk02 284 2 for for IN cord-014516-r59usk02 284 3 values value NNS cord-014516-r59usk02 284 4 normalized normalize VBN cord-014516-r59usk02 284 5 to to IN cord-014516-r59usk02 284 6 Ao Ao NNP cord-014516-r59usk02 284 7 diameter diameter NN cord-014516-r59usk02 284 8 behaved behave VBN cord-014516-r59usk02 284 9 in in IN cord-014516-r59usk02 284 10 a a DT cord-014516-r59usk02 284 11 parallel parallel JJ cord-014516-r59usk02 284 12 way way NN cord-014516-r59usk02 284 13 . . . cord-014516-r59usk02 285 1 We -PRON- PRP cord-014516-r59usk02 285 2 conclude conclude VBP cord-014516-r59usk02 285 3 that that IN cord-014516-r59usk02 285 4 FS FS NNP cord-014516-r59usk02 285 5 , , , cord-014516-r59usk02 285 6 left leave VBN cord-014516-r59usk02 285 7 ventricular ventricular JJ cord-014516-r59usk02 285 8 and and CC cord-014516-r59usk02 285 9 atrial atrial JJ cord-014516-r59usk02 285 10 size size NN cord-014516-r59usk02 285 11 may may MD cord-014516-r59usk02 285 12 be be VB cord-014516-r59usk02 285 13 used use VBN cord-014516-r59usk02 285 14 to to TO cord-014516-r59usk02 285 15 predict predict VB cord-014516-r59usk02 285 16 CHF CHF NNP cord-014516-r59usk02 285 17 . . . cord-014516-r59usk02 286 1 However however RB cord-014516-r59usk02 286 2 , , , cord-014516-r59usk02 286 3 because because IN cord-014516-r59usk02 286 4 the the DT cord-014516-r59usk02 286 5 value value NN cord-014516-r59usk02 286 6 of of IN cord-014516-r59usk02 286 7 a a DT cord-014516-r59usk02 286 8 HR hr NN cord-014516-r59usk02 286 9 is be VBZ cord-014516-r59usk02 286 10 dependent dependent JJ cord-014516-r59usk02 286 11 on on IN cord-014516-r59usk02 286 12 the the DT cord-014516-r59usk02 286 13 unit unit NN cord-014516-r59usk02 286 14 used use VBN cord-014516-r59usk02 286 15 and and CC cord-014516-r59usk02 286 16 , , , cord-014516-r59usk02 286 17 more more RBR cord-014516-r59usk02 286 18 essentially essentially RB cord-014516-r59usk02 286 19 , , , cord-014516-r59usk02 286 20 does do VBZ cord-014516-r59usk02 286 21 not not RB cord-014516-r59usk02 286 22 account account VB cord-014516-r59usk02 286 23 for for IN cord-014516-r59usk02 286 24 nonlinear nonlinear JJ cord-014516-r59usk02 286 25 change change NN cord-014516-r59usk02 286 26 in in IN cord-014516-r59usk02 286 27 hazard hazard NN cord-014516-r59usk02 286 28 , , , cord-014516-r59usk02 286 29 interpretation interpretation NN cord-014516-r59usk02 286 30 of of IN cord-014516-r59usk02 286 31 hazards hazard NNS cord-014516-r59usk02 286 32 is be VBZ cord-014516-r59usk02 286 33 challenging challenging JJ cord-014516-r59usk02 286 34 . . . cord-014516-r59usk02 287 1 In in IN cord-014516-r59usk02 287 2 contrast contrast NN cord-014516-r59usk02 287 3 , , , cord-014516-r59usk02 287 4 interval interval NN cord-014516-r59usk02 287 5 hazards hazard NNS cord-014516-r59usk02 287 6 are be VBP cord-014516-r59usk02 287 7 only only RB cord-014516-r59usk02 287 8 dependent dependent JJ cord-014516-r59usk02 287 9 on on IN cord-014516-r59usk02 287 10 the the DT cord-014516-r59usk02 287 11 reference reference NN cord-014516-r59usk02 287 12 interval interval NN cord-014516-r59usk02 287 13 used use VBN cord-014516-r59usk02 287 14 . . . cord-014516-r59usk02 288 1 Therefore therefore RB cord-014516-r59usk02 288 2 they -PRON- PRP cord-014516-r59usk02 288 3 are be VBP cord-014516-r59usk02 288 4 easier easy JJR cord-014516-r59usk02 288 5 to to TO cord-014516-r59usk02 288 6 implement implement VB cord-014516-r59usk02 288 7 in in IN cord-014516-r59usk02 288 8 every every DT cord-014516-r59usk02 288 9 day day NN cord-014516-r59usk02 288 10 clinical clinical JJ cord-014516-r59usk02 288 11 work work NN cord-014516-r59usk02 288 12 . . . cord-014516-r59usk02 289 1 No no DT cord-014516-r59usk02 289 2 conflicts conflict NNS cord-014516-r59usk02 289 3 of of IN cord-014516-r59usk02 289 4 interest interest NN cord-014516-r59usk02 289 5 reported report VBN cord-014516-r59usk02 289 6 . . . cord-014516-r59usk02 290 1 Systemic systemic JJ cord-014516-r59usk02 290 2 arterial arterial JJ cord-014516-r59usk02 290 3 hypertension hypertension NN cord-014516-r59usk02 290 4 is be VBZ cord-014516-r59usk02 290 5 not not RB cord-014516-r59usk02 290 6 frequently frequently RB cord-014516-r59usk02 290 7 recognized recognize VBN cord-014516-r59usk02 290 8 in in IN cord-014516-r59usk02 290 9 dogs dog NNS cord-014516-r59usk02 290 10 with with IN cord-014516-r59usk02 290 11 mitral mitral JJ cord-014516-r59usk02 290 12 valve valve NN cord-014516-r59usk02 290 13 degeneration degeneration NN cord-014516-r59usk02 290 14 ( ( -LRB- cord-014516-r59usk02 290 15 MVD MVD NNP cord-014516-r59usk02 290 16 ) ) -RRB- cord-014516-r59usk02 290 17 , , , cord-014516-r59usk02 290 18 although although IN cord-014516-r59usk02 290 19 borderline borderline JJ cord-014516-r59usk02 290 20 hypertension hypertension NN cord-014516-r59usk02 290 21 is be VBZ cord-014516-r59usk02 290 22 difficult difficult JJ cord-014516-r59usk02 290 23 to to TO cord-014516-r59usk02 290 24 assess assess VB cord-014516-r59usk02 290 25 , , , cord-014516-r59usk02 290 26 mainly mainly RB cord-014516-r59usk02 290 27 because because IN cord-014516-r59usk02 290 28 of of IN cord-014516-r59usk02 290 29 different different JJ cord-014516-r59usk02 290 30 measurement measurement NN cord-014516-r59usk02 290 31 techniques technique NNS cord-014516-r59usk02 290 32 , , , cord-014516-r59usk02 290 33 inter inter JJ cord-014516-r59usk02 290 34 - - JJ cord-014516-r59usk02 290 35 operator operator JJ cord-014516-r59usk02 290 36 variability variability NN cord-014516-r59usk02 290 37 and and CC cord-014516-r59usk02 290 38 , , , cord-014516-r59usk02 290 39 most most RBS cord-014516-r59usk02 290 40 importantly importantly RB cord-014516-r59usk02 290 41 , , , cord-014516-r59usk02 290 42 examination examination NN cord-014516-r59usk02 290 43 - - HYPH cord-014516-r59usk02 290 44 related relate VBN cord-014516-r59usk02 290 45 stress stress NN cord-014516-r59usk02 290 46 . . . cord-014516-r59usk02 291 1 The the DT cord-014516-r59usk02 291 2 object object NN cord-014516-r59usk02 291 3 of of IN cord-014516-r59usk02 291 4 this this DT cord-014516-r59usk02 291 5 study study NN cord-014516-r59usk02 291 6 was be VBD cord-014516-r59usk02 291 7 to to TO cord-014516-r59usk02 291 8 evaluate evaluate VB cord-014516-r59usk02 291 9 systolic systolic JJ cord-014516-r59usk02 291 10 arterial arterial JJ cord-014516-r59usk02 291 11 blood blood NN cord-014516-r59usk02 291 12 pressure pressure NN cord-014516-r59usk02 291 13 ( ( -LRB- cord-014516-r59usk02 291 14 SBP SBP NNP cord-014516-r59usk02 291 15 ) ) -RRB- cord-014516-r59usk02 291 16 at at IN cord-014516-r59usk02 291 17 initial initial JJ cord-014516-r59usk02 291 18 presentation presentation NN cord-014516-r59usk02 291 19 and and CC cord-014516-r59usk02 291 20 at at IN cord-014516-r59usk02 291 21 regular regular JJ cord-014516-r59usk02 291 22 intervals interval NNS cord-014516-r59usk02 291 23 in in IN cord-014516-r59usk02 291 24 dogs dog NNS cord-014516-r59usk02 291 25 with with IN cord-014516-r59usk02 291 26 various various JJ cord-014516-r59usk02 291 27 clinical clinical JJ cord-014516-r59usk02 291 28 stages stage NNS cord-014516-r59usk02 291 29 of of IN cord-014516-r59usk02 291 30 MVD MVD NNP cord-014516-r59usk02 291 31 . . . cord-014516-r59usk02 292 1 Fifty fifty CD cord-014516-r59usk02 292 2 six six CD cord-014516-r59usk02 292 3 dogs dog NNS cord-014516-r59usk02 292 4 with with IN cord-014516-r59usk02 292 5 MVD MVD NNP cord-014516-r59usk02 292 6 that that WDT cord-014516-r59usk02 292 7 had have VBD cord-014516-r59usk02 292 8 not not RB cord-014516-r59usk02 292 9 received receive VBN cord-014516-r59usk02 292 10 any any DT cord-014516-r59usk02 292 11 heart heart NN cord-014516-r59usk02 292 12 medication medication NN cord-014516-r59usk02 292 13 prior prior RB cord-014516-r59usk02 292 14 to to IN cord-014516-r59usk02 292 15 admission admission NN cord-014516-r59usk02 292 16 , , , cord-014516-r59usk02 292 17 were be VBD cord-014516-r59usk02 292 18 included include VBN cord-014516-r59usk02 292 19 in in IN cord-014516-r59usk02 292 20 the the DT cord-014516-r59usk02 292 21 study study NN cord-014516-r59usk02 292 22 . . . cord-014516-r59usk02 293 1 Based base VBN cord-014516-r59usk02 293 2 on on IN cord-014516-r59usk02 293 3 the the DT cord-014516-r59usk02 293 4 ISACHC ISACHC NNP cord-014516-r59usk02 293 5 staging staging NN cord-014516-r59usk02 293 6 system system NN cord-014516-r59usk02 293 7 , , , cord-014516-r59usk02 293 8 22 22 CD cord-014516-r59usk02 293 9 were be VBD cord-014516-r59usk02 293 10 assigned assign VBN cord-014516-r59usk02 293 11 to to IN cord-014516-r59usk02 293 12 class class NN cord-014516-r59usk02 293 13 I -PRON- PRP cord-014516-r59usk02 293 14 ( ( -LRB- cord-014516-r59usk02 293 15 Group Group NNP cord-014516-r59usk02 293 16 A A NNP cord-014516-r59usk02 293 17 ) ) -RRB- cord-014516-r59usk02 293 18 , , , cord-014516-r59usk02 293 19 18 18 CD cord-014516-r59usk02 293 20 to to IN cord-014516-r59usk02 293 21 class class NN cord-014516-r59usk02 293 22 II II NNP cord-014516-r59usk02 293 23 ( ( -LRB- cord-014516-r59usk02 293 24 Group Group NNP cord-014516-r59usk02 293 25 B B NNP cord-014516-r59usk02 293 26 ) ) -RRB- cord-014516-r59usk02 293 27 and and CC cord-014516-r59usk02 293 28 16 16 CD cord-014516-r59usk02 293 29 to to IN cord-014516-r59usk02 293 30 class class NN cord-014516-r59usk02 293 31 III iii CD cord-014516-r59usk02 293 32 . . . cord-014516-r59usk02 294 1 Small small JJ cord-014516-r59usk02 294 2 - - HYPH cord-014516-r59usk02 294 3 breed breed NN cord-014516-r59usk02 294 4 dogs dog NNS cord-014516-r59usk02 294 5 and and CC cord-014516-r59usk02 294 6 miniature miniature JJ cord-014516-r59usk02 294 7 Poodles poodle NNS cord-014516-r59usk02 294 8 , , , cord-014516-r59usk02 294 9 in in IN cord-014516-r59usk02 294 10 particular particular JJ cord-014516-r59usk02 294 11 , , , cord-014516-r59usk02 294 12 were be VBD cord-014516-r59usk02 294 13 overrepresented overrepresente VBN cord-014516-r59usk02 294 14 . . . cord-014516-r59usk02 295 1 Comorbidities comorbiditie NNS cord-014516-r59usk02 295 2 that that WDT cord-014516-r59usk02 295 3 could could MD cord-014516-r59usk02 295 4 affect affect VB cord-014516-r59usk02 295 5 SBP SBP NNP cord-014516-r59usk02 295 6 were be VBD cord-014516-r59usk02 295 7 ruled rule VBN cord-014516-r59usk02 295 8 out out RP cord-014516-r59usk02 295 9 prior prior RB cord-014516-r59usk02 295 10 to to IN cord-014516-r59usk02 295 11 enrollment enrollment NN cord-014516-r59usk02 295 12 . . . cord-014516-r59usk02 296 1 SBP SBP NNP cord-014516-r59usk02 296 2 was be VBD cord-014516-r59usk02 296 3 measured measure VBN cord-014516-r59usk02 296 4 using use VBG cord-014516-r59usk02 296 5 a a DT cord-014516-r59usk02 296 6 commercially commercially RB cord-014516-r59usk02 296 7 available available JJ cord-014516-r59usk02 296 8 veterinary veterinary JJ cord-014516-r59usk02 296 9 oscillometric oscillometric NN cord-014516-r59usk02 296 10 device device NN cord-014516-r59usk02 296 11 , , , cord-014516-r59usk02 296 12 by by IN cord-014516-r59usk02 296 13 applying apply VBG cord-014516-r59usk02 296 14 the the DT cord-014516-r59usk02 296 15 proper proper JJ cord-014516-r59usk02 296 16 cuff cuff NN cord-014516-r59usk02 296 17 on on IN cord-014516-r59usk02 296 18 the the DT cord-014516-r59usk02 296 19 cephalic cephalic JJ cord-014516-r59usk02 296 20 artery artery NN cord-014516-r59usk02 296 21 . . . cord-014516-r59usk02 297 1 Dogs dog NNS cord-014516-r59usk02 297 2 were be VBD cord-014516-r59usk02 297 3 left leave VBN cord-014516-r59usk02 297 4 to to TO cord-014516-r59usk02 297 5 acclimate acclimate VB cord-014516-r59usk02 297 6 for for IN cord-014516-r59usk02 297 7 10 10 CD cord-014516-r59usk02 297 8 -15 -15 CD cord-014516-r59usk02 297 9 minutes minute NNS cord-014516-r59usk02 297 10 and and CC cord-014516-r59usk02 297 11 measurements measurement NNS cord-014516-r59usk02 297 12 were be VBD cord-014516-r59usk02 297 13 always always RB cord-014516-r59usk02 297 14 taken take VBN cord-014516-r59usk02 297 15 by by IN cord-014516-r59usk02 297 16 the the DT cord-014516-r59usk02 297 17 same same JJ cord-014516-r59usk02 297 18 investigator investigator NN cord-014516-r59usk02 297 19 , , , cord-014516-r59usk02 297 20 before before IN cord-014516-r59usk02 297 21 any any DT cord-014516-r59usk02 297 22 other other JJ cord-014516-r59usk02 297 23 examination examination NN cord-014516-r59usk02 297 24 was be VBD cord-014516-r59usk02 297 25 performed perform VBN cord-014516-r59usk02 297 26 , , , cord-014516-r59usk02 297 27 with with IN cord-014516-r59usk02 297 28 the the DT cord-014516-r59usk02 297 29 dog dog NN cord-014516-r59usk02 297 30 sitting sit VBG cord-014516-r59usk02 297 31 on on IN cord-014516-r59usk02 297 32 the the DT cord-014516-r59usk02 297 33 owner owner NN cord-014516-r59usk02 297 34 's 's POS cord-014516-r59usk02 297 35 lap lap NN cord-014516-r59usk02 297 36 . . . cord-014516-r59usk02 298 1 A a DT cord-014516-r59usk02 298 2 total total NN cord-014516-r59usk02 298 3 of of IN cord-014516-r59usk02 298 4 5 5 CD cord-014516-r59usk02 298 5 readings reading NNS cord-014516-r59usk02 298 6 were be VBD cord-014516-r59usk02 298 7 taken take VBN cord-014516-r59usk02 298 8 , , , cord-014516-r59usk02 298 9 outlier outlier JJ cord-014516-r59usk02 298 10 values value NNS cord-014516-r59usk02 298 11 were be VBD cord-014516-r59usk02 298 12 discarded discard VBN cord-014516-r59usk02 298 13 and and CC cord-014516-r59usk02 298 14 the the DT cord-014516-r59usk02 298 15 mean mean NN cord-014516-r59usk02 298 16 of of IN cord-014516-r59usk02 298 17 the the DT cord-014516-r59usk02 298 18 3 3 CD cord-014516-r59usk02 298 19 remaining remain VBG cord-014516-r59usk02 298 20 measurements measurement NNS cord-014516-r59usk02 298 21 was be VBD cord-014516-r59usk02 298 22 documented document VBN cord-014516-r59usk02 298 23 . . . cord-014516-r59usk02 299 1 After after IN cord-014516-r59usk02 299 2 initial initial JJ cord-014516-r59usk02 299 3 consultation consultation NN cord-014516-r59usk02 299 4 , , , cord-014516-r59usk02 299 5 treatment treatment NN cord-014516-r59usk02 299 6 was be VBD cord-014516-r59usk02 299 7 customized customize VBN cord-014516-r59usk02 299 8 according accord VBG cord-014516-r59usk02 299 9 to to IN cord-014516-r59usk02 299 10 the the DT cord-014516-r59usk02 299 11 clinical clinical JJ cord-014516-r59usk02 299 12 stage stage NN cord-014516-r59usk02 299 13 . . . cord-014516-r59usk02 300 1 SBP SBP NNP cord-014516-r59usk02 300 2 was be VBD cord-014516-r59usk02 300 3 then then RB cord-014516-r59usk02 300 4 measured measure VBN cord-014516-r59usk02 300 5 every every DT cord-014516-r59usk02 300 6 2 2 CD cord-014516-r59usk02 300 7 months month NNS cord-014516-r59usk02 300 8 , , , cord-014516-r59usk02 300 9 up up IN cord-014516-r59usk02 300 10 to to TO cord-014516-r59usk02 300 11 6 6 CD cord-014516-r59usk02 300 12 months month NNS cord-014516-r59usk02 300 13 after after IN cord-014516-r59usk02 300 14 initial initial JJ cord-014516-r59usk02 300 15 admission admission NN cord-014516-r59usk02 300 16 . . . cord-014516-r59usk02 301 1 At at IN cord-014516-r59usk02 301 2 presentation presentation NN cord-014516-r59usk02 301 3 , , , cord-014516-r59usk02 301 4 all all DT cord-014516-r59usk02 301 5 class class NN cord-014516-r59usk02 301 6 I -PRON- PRP cord-014516-r59usk02 301 7 dogs dog NNS cord-014516-r59usk02 301 8 had have VBD cord-014516-r59usk02 301 9 SBP SBP NNP cord-014516-r59usk02 302 1 > > XX cord-014516-r59usk02 303 1 140 140 CD cord-014516-r59usk02 303 2 mm mm NN cord-014516-r59usk02 304 1 Hg Hg NNP cord-014516-r59usk02 304 2 , , , cord-014516-r59usk02 304 3 with with IN cord-014516-r59usk02 304 4 only only RB cord-014516-r59usk02 304 5 5/22 5/22 CD cord-014516-r59usk02 304 6 having have VBG cord-014516-r59usk02 304 7 SPB SPB NNP cord-014516-r59usk02 304 8 ≥150 ≥150 NN cord-014516-r59usk02 304 9 mm mm NN cord-014516-r59usk02 305 1 Hg Hg NNP cord-014516-r59usk02 305 2 , , , cord-014516-r59usk02 305 3 whereas whereas IN cord-014516-r59usk02 305 4 all all DT cord-014516-r59usk02 305 5 class class NN cord-014516-r59usk02 305 6 II ii CD cord-014516-r59usk02 305 7 dogs dog NNS cord-014516-r59usk02 305 8 had have VBD cord-014516-r59usk02 305 9 SBP SBP NNP cord-014516-r59usk02 305 10 < < XX cord-014516-r59usk02 305 11 140 140 CD cord-014516-r59usk02 305 12 mm mm NN cord-014516-r59usk02 306 1 Hg Hg NNP cord-014516-r59usk02 306 2 . . . cord-014516-r59usk02 307 1 Of of IN cord-014516-r59usk02 307 2 class class NN cord-014516-r59usk02 307 3 III iii CD cord-014516-r59usk02 307 4 dogs dog NNS cord-014516-r59usk02 307 5 , , , cord-014516-r59usk02 307 6 6 6 CD cord-014516-r59usk02 307 7 had have VBD cord-014516-r59usk02 308 1 SBP SBP NNP cord-014516-r59usk02 309 1 > > XX cord-014516-r59usk02 310 1 140 140 CD cord-014516-r59usk02 310 2 mm mm CD cord-014516-r59usk02 310 3 Hg Hg NNP cord-014516-r59usk02 310 4 , , , cord-014516-r59usk02 310 5 and and CC cord-014516-r59usk02 310 6 2 2 CD cord-014516-r59usk02 310 7 had have VBD cord-014516-r59usk02 310 8 SBP SBP NNP cord-014516-r59usk02 310 9 ≥ ≥ CD cord-014516-r59usk02 311 1 150 150 CD cord-014516-r59usk02 311 2 mm mm CD cord-014516-r59usk02 311 3 Hg Hg NNS cord-014516-r59usk02 311 4 . . . cord-014516-r59usk02 312 1 A a DT cord-014516-r59usk02 312 2 linear linear JJ cord-014516-r59usk02 312 3 mixed mixed JJ cord-014516-r59usk02 312 4 effects effect NNS cord-014516-r59usk02 312 5 model model NN cord-014516-r59usk02 312 6 was be VBD cord-014516-r59usk02 312 7 used use VBN cord-014516-r59usk02 312 8 to to TO cord-014516-r59usk02 312 9 assess assess VB cord-014516-r59usk02 312 10 the the DT cord-014516-r59usk02 312 11 temporal temporal JJ cord-014516-r59usk02 312 12 variability variability NN cord-014516-r59usk02 312 13 of of IN cord-014516-r59usk02 312 14 the the DT cord-014516-r59usk02 312 15 measured measure VBN cord-014516-r59usk02 312 16 parameters parameter NNS cord-014516-r59usk02 312 17 between between IN cord-014516-r59usk02 312 18 groups group NNS cord-014516-r59usk02 312 19 . . . cord-014516-r59usk02 313 1 Groups group NNS cord-014516-r59usk02 313 2 were be VBD cord-014516-r59usk02 313 3 matched match VBN cord-014516-r59usk02 313 4 for for IN cord-014516-r59usk02 313 5 gender gender NN cord-014516-r59usk02 313 6 , , , cord-014516-r59usk02 313 7 age age NN cord-014516-r59usk02 313 8 and and CC cord-014516-r59usk02 313 9 body body NN cord-014516-r59usk02 313 10 weight weight NN cord-014516-r59usk02 313 11 . . . cord-014516-r59usk02 314 1 Blood blood NN cord-014516-r59usk02 314 2 pressure pressure NN cord-014516-r59usk02 314 3 measurements measurement NNS cord-014516-r59usk02 314 4 , , , cord-014516-r59usk02 314 5 for for IN cord-014516-r59usk02 314 6 the the DT cord-014516-r59usk02 314 7 duration duration NN cord-014516-r59usk02 314 8 of of IN cord-014516-r59usk02 314 9 the the DT cord-014516-r59usk02 314 10 study study NN cord-014516-r59usk02 314 11 , , , cord-014516-r59usk02 314 12 were be VBD cord-014516-r59usk02 314 13 higher high JJR cord-014516-r59usk02 314 14 in in IN cord-014516-r59usk02 314 15 Group Group NNP cord-014516-r59usk02 314 16 A A NNP cord-014516-r59usk02 314 17 dogs dog NNS cord-014516-r59usk02 314 18 , , , cord-014516-r59usk02 314 19 compared compare VBN cord-014516-r59usk02 314 20 to to IN cord-014516-r59usk02 314 21 groups group NNS cord-014516-r59usk02 314 22 B b NN cord-014516-r59usk02 314 23 and and CC cord-014516-r59usk02 314 24 C c NN cord-014516-r59usk02 314 25 ( ( -LRB- cord-014516-r59usk02 314 26 P p NN cord-014516-r59usk02 314 27 < < XX cord-014516-r59usk02 314 28 0,001 0,001 CD cord-014516-r59usk02 314 29 ) ) -RRB- cord-014516-r59usk02 314 30 . . . cord-014516-r59usk02 315 1 At at IN cord-014516-r59usk02 315 2 the the DT cord-014516-r59usk02 315 3 same same JJ cord-014516-r59usk02 315 4 time time NN cord-014516-r59usk02 315 5 , , , cord-014516-r59usk02 315 6 Group Group NNP cord-014516-r59usk02 315 7 C C NNP cord-014516-r59usk02 315 8 had have VBD cord-014516-r59usk02 315 9 significantly significantly RB cord-014516-r59usk02 315 10 higher high JJR cord-014516-r59usk02 315 11 SBP SBP NNP cord-014516-r59usk02 315 12 values value NNS cord-014516-r59usk02 315 13 than than IN cord-014516-r59usk02 315 14 Group Group NNP cord-014516-r59usk02 315 15 B B NNP cord-014516-r59usk02 315 16 dogs dog NNS cord-014516-r59usk02 315 17 ( ( -LRB- cord-014516-r59usk02 315 18 p p NN cord-014516-r59usk02 315 19 < < XX cord-014516-r59usk02 315 20 0,001 0,001 CD cord-014516-r59usk02 315 21 ) ) -RRB- cord-014516-r59usk02 315 22 . . . cord-014516-r59usk02 316 1 Asymptomatic asymptomatic JJ cord-014516-r59usk02 316 2 MVD MVD NNP cord-014516-r59usk02 316 3 dogs dog NNS cord-014516-r59usk02 316 4 seem seem VBP cord-014516-r59usk02 316 5 to to TO cord-014516-r59usk02 316 6 have have VB cord-014516-r59usk02 316 7 higher high JJR cord-014516-r59usk02 316 8 SBP SBP NNP cord-014516-r59usk02 316 9 measurements measurement NNS cord-014516-r59usk02 316 10 , , , cord-014516-r59usk02 316 11 compared compare VBN cord-014516-r59usk02 316 12 to to IN cord-014516-r59usk02 316 13 those those DT cord-014516-r59usk02 316 14 with with IN cord-014516-r59usk02 316 15 clinical clinical JJ cord-014516-r59usk02 316 16 evidence evidence NN cord-014516-r59usk02 316 17 of of IN cord-014516-r59usk02 316 18 heart heart NN cord-014516-r59usk02 316 19 failure failure NN cord-014516-r59usk02 316 20 . . . cord-014516-r59usk02 317 1 Whether whether IN cord-014516-r59usk02 317 2 this this DT cord-014516-r59usk02 317 3 difference difference NN cord-014516-r59usk02 317 4 is be VBZ cord-014516-r59usk02 317 5 stress stress NN cord-014516-r59usk02 317 6 - - HYPH cord-014516-r59usk02 317 7 related relate VBN cord-014516-r59usk02 317 8 , , , cord-014516-r59usk02 317 9 a a DT cord-014516-r59usk02 317 10 maladaptive maladaptive JJ cord-014516-r59usk02 317 11 mechanism mechanism NN cord-014516-r59usk02 317 12 of of IN cord-014516-r59usk02 317 13 sympathetic sympathetic JJ cord-014516-r59usk02 317 14 and and CC cord-014516-r59usk02 317 15 RAAS RAAS NNP cord-014516-r59usk02 317 16 activation activation NN cord-014516-r59usk02 317 17 to to IN cord-014516-r59usk02 317 18 MVD MVD NNP cord-014516-r59usk02 317 19 or or CC cord-014516-r59usk02 317 20 idiopathic idiopathic JJ cord-014516-r59usk02 317 21 remains remain VBZ cord-014516-r59usk02 317 22 to to TO cord-014516-r59usk02 317 23 be be VB cord-014516-r59usk02 317 24 elucidated elucidate VBN cord-014516-r59usk02 317 25 . . . cord-014516-r59usk02 318 1 No no DT cord-014516-r59usk02 318 2 conflicts conflict NNS cord-014516-r59usk02 318 3 of of IN cord-014516-r59usk02 318 4 interest interest NN cord-014516-r59usk02 318 5 reported report VBN cord-014516-r59usk02 318 6 . . . cord-014516-r59usk02 319 1 Sarcoplasmic sarcoplasmic NN cord-014516-r59usk02 319 2 reticulum reticulum NN cord-014516-r59usk02 319 3 ( ( -LRB- cord-014516-r59usk02 319 4 SR SR NNP cord-014516-r59usk02 319 5 ) ) -RRB- cord-014516-r59usk02 320 1 Ca ca RB cord-014516-r59usk02 320 2 2 2 CD cord-014516-r59usk02 321 1 + + CC cord-014516-r59usk02 322 1 -ATPase -ATPase NNP cord-014516-r59usk02 323 1 and and CC cord-014516-r59usk02 323 2 its -PRON- PRP$ cord-014516-r59usk02 323 3 regulatory regulatory JJ cord-014516-r59usk02 323 4 proteins protein NNS cord-014516-r59usk02 323 5 are be VBP cord-014516-r59usk02 323 6 pivotal pivotal JJ cord-014516-r59usk02 323 7 determinants determinant NNS cord-014516-r59usk02 323 8 of of IN cord-014516-r59usk02 323 9 myocardial myocardial JJ cord-014516-r59usk02 323 10 active active JJ cord-014516-r59usk02 323 11 relaxation relaxation NN cord-014516-r59usk02 323 12 via via IN cord-014516-r59usk02 323 13 calcium calcium NN cord-014516-r59usk02 323 14 uptake uptake NN cord-014516-r59usk02 323 15 against against IN cord-014516-r59usk02 323 16 the the DT cord-014516-r59usk02 323 17 SR SR NNP cord-014516-r59usk02 323 18 - - HYPH cord-014516-r59usk02 323 19 cytoplasmic cytoplasmic JJ cord-014516-r59usk02 323 20 gradient gradient NN cord-014516-r59usk02 323 21 . . . cord-014516-r59usk02 324 1 The the DT cord-014516-r59usk02 324 2 lowered lower VBN cord-014516-r59usk02 324 3 density density NN cord-014516-r59usk02 324 4 of of IN cord-014516-r59usk02 324 5 the the DT cord-014516-r59usk02 324 6 SR SR NNP cord-014516-r59usk02 325 1 Ca ca NN cord-014516-r59usk02 325 2 2 2 CD cord-014516-r59usk02 325 3 + + CC cord-014516-r59usk02 325 4 -ATPase -atpase NN cord-014516-r59usk02 325 5 has have VBZ cord-014516-r59usk02 325 6 been be VBN cord-014516-r59usk02 325 7 well well RB cord-014516-r59usk02 325 8 demonstrated demonstrate VBN cord-014516-r59usk02 325 9 in in IN cord-014516-r59usk02 325 10 many many JJ cord-014516-r59usk02 325 11 species specie NNS cord-014516-r59usk02 325 12 during during IN cord-014516-r59usk02 325 13 chronic chronic JJ cord-014516-r59usk02 325 14 hemodynamic hemodynamic JJ cord-014516-r59usk02 325 15 overload overload NN cord-014516-r59usk02 325 16 . . . cord-014516-r59usk02 326 1 The the DT cord-014516-r59usk02 326 2 genes gene NNS cord-014516-r59usk02 326 3 linked link VBN cord-014516-r59usk02 326 4 to to IN cord-014516-r59usk02 326 5 SR SR NNP cord-014516-r59usk02 326 6 calcium calcium NN cord-014516-r59usk02 326 7 uptake uptake NN cord-014516-r59usk02 326 8 were be VBD cord-014516-r59usk02 326 9 reported report VBN cord-014516-r59usk02 326 10 not not RB cord-014516-r59usk02 326 11 only only RB cord-014516-r59usk02 326 12 being be VBG cord-014516-r59usk02 326 13 expressed express VBN cord-014516-r59usk02 326 14 in in IN cord-014516-r59usk02 326 15 peripheral peripheral JJ cord-014516-r59usk02 326 16 blood blood NN cord-014516-r59usk02 326 17 but but CC cord-014516-r59usk02 326 18 serving serve VBG cord-014516-r59usk02 326 19 as as IN cord-014516-r59usk02 326 20 potential potential JJ cord-014516-r59usk02 326 21 cardiac cardiac JJ cord-014516-r59usk02 326 22 biomarkers biomarker NNS cord-014516-r59usk02 326 23 in in IN cord-014516-r59usk02 326 24 dogs dog NNS cord-014516-r59usk02 326 25 with with IN cord-014516-r59usk02 326 26 chronic chronic JJ cord-014516-r59usk02 326 27 mitral mitral JJ cord-014516-r59usk02 326 28 regurgitation regurgitation NN cord-014516-r59usk02 326 29 , , , cord-014516-r59usk02 326 30 such such JJ cord-014516-r59usk02 326 31 as as IN cord-014516-r59usk02 326 32 SR SR NNP cord-014516-r59usk02 326 33 Ca Ca NNP cord-014516-r59usk02 326 34 2 2 CD cord-014516-r59usk02 326 35 + + SYM cord-014516-r59usk02 326 36 adenosine adenosine NN cord-014516-r59usk02 326 37 triphosphatase triphosphatase NN cord-014516-r59usk02 326 38 isoform isoform NN cord-014516-r59usk02 326 39 2a 2a CD cord-014516-r59usk02 326 40 ( ( -LRB- cord-014516-r59usk02 326 41 SER SER NNP cord-014516-r59usk02 326 42 - - HYPH cord-014516-r59usk02 326 43 CA2a CA2a NNP cord-014516-r59usk02 326 44 ) ) -RRB- cord-014516-r59usk02 326 45 , , , cord-014516-r59usk02 326 46 phospholamban phospholamban NNP cord-014516-r59usk02 326 47 ( ( -LRB- cord-014516-r59usk02 326 48 PLN PLN NNP cord-014516-r59usk02 326 49 ) ) -RRB- cord-014516-r59usk02 326 50 , , , cord-014516-r59usk02 326 51 and and CC cord-014516-r59usk02 326 52 HS-1 HS-1 NNP cord-014516-r59usk02 326 53 associated associate VBD cord-014516-r59usk02 326 54 protein protein NN cord-014516-r59usk02 326 55 X-1 x-1 NN cord-014516-r59usk02 326 56 ( ( -LRB- cord-014516-r59usk02 326 57 HAX-1 HAX-1 NNP cord-014516-r59usk02 326 58 ) ) -RRB- cord-014516-r59usk02 326 59 . . . cord-014516-r59usk02 327 1 The the DT cord-014516-r59usk02 327 2 aim aim NN cord-014516-r59usk02 327 3 of of IN cord-014516-r59usk02 327 4 this this DT cord-014516-r59usk02 327 5 study study NN cord-014516-r59usk02 327 6 is be VBZ cord-014516-r59usk02 327 7 to to TO cord-014516-r59usk02 327 8 determine determine VB cord-014516-r59usk02 327 9 whether whether IN cord-014516-r59usk02 327 10 the the DT cord-014516-r59usk02 327 11 target target NN cord-014516-r59usk02 327 12 genes gene NNS cord-014516-r59usk02 327 13 expressed express VBN cord-014516-r59usk02 327 14 in in IN cord-014516-r59usk02 327 15 the the DT cord-014516-r59usk02 327 16 blood blood NN cord-014516-r59usk02 327 17 will will MD cord-014516-r59usk02 327 18 be be VB cord-014516-r59usk02 327 19 translatable translatable JJ cord-014516-r59usk02 327 20 to to IN cord-014516-r59usk02 327 21 the the DT cord-014516-r59usk02 327 22 myocardial myocardial JJ cord-014516-r59usk02 327 23 setting setting NN cord-014516-r59usk02 327 24 as as IN cord-014516-r59usk02 327 25 cardiac cardiac JJ cord-014516-r59usk02 327 26 biomarkers biomarker NNS cord-014516-r59usk02 327 27 . . . cord-014516-r59usk02 328 1 The the DT cord-014516-r59usk02 328 2 mRNA mrna NN cord-014516-r59usk02 328 3 expression expression NN cord-014516-r59usk02 328 4 levels level NNS cord-014516-r59usk02 328 5 of of IN cord-014516-r59usk02 328 6 the the DT cord-014516-r59usk02 328 7 target target NN cord-014516-r59usk02 328 8 genes gene NNS cord-014516-r59usk02 328 9 ( ( -LRB- cord-014516-r59usk02 328 10 SERCA2a serca2a NN cord-014516-r59usk02 328 11 , , , cord-014516-r59usk02 328 12 PLN PLN NNP cord-014516-r59usk02 328 13 , , , cord-014516-r59usk02 328 14 HAX-1 HAX-1 NNP cord-014516-r59usk02 328 15 ) ) -RRB- cord-014516-r59usk02 328 16 from from IN cord-014516-r59usk02 328 17 biopsied biopsie VBN cord-014516-r59usk02 328 18 left left JJ cord-014516-r59usk02 328 19 ventricle ventricle NN cord-014516-r59usk02 328 20 ( ( -LRB- cord-014516-r59usk02 328 21 LV LV NNP cord-014516-r59usk02 328 22 ) ) -RRB- cord-014516-r59usk02 328 23 and and CC cord-014516-r59usk02 328 24 peripheral peripheral JJ cord-014516-r59usk02 328 25 white white JJ cord-014516-r59usk02 328 26 blood blood NN cord-014516-r59usk02 328 27 cells cell NNS cord-014516-r59usk02 328 28 ( ( -LRB- cord-014516-r59usk02 328 29 PWBC PWBC NNP cord-014516-r59usk02 328 30 ) ) -RRB- cord-014516-r59usk02 328 31 in in IN cord-014516-r59usk02 328 32 129 129 CD cord-014516-r59usk02 328 33 surgical surgical JJ cord-014516-r59usk02 328 34 mitral mitral JJ cord-014516-r59usk02 328 35 valve valve NN cord-014516-r59usk02 328 36 repair repair NN cord-014516-r59usk02 328 37 cases case NNS cord-014516-r59usk02 328 38 were be VBD cord-014516-r59usk02 328 39 estimated estimate VBN cord-014516-r59usk02 328 40 with with IN cord-014516-r59usk02 328 41 quantitative quantitative JJ cord-014516-r59usk02 328 42 real real JJ cord-014516-r59usk02 328 43 - - HYPH cord-014516-r59usk02 328 44 time time NN cord-014516-r59usk02 328 45 PCR pcr NN cord-014516-r59usk02 328 46 using use VBG cord-014516-r59usk02 328 47 comparative comparative JJ cord-014516-r59usk02 328 48 Ct Ct NNP cord-014516-r59usk02 328 49 method method NN cord-014516-r59usk02 328 50 with with IN cord-014516-r59usk02 328 51 GAPDH GAPDH NNP cord-014516-r59usk02 328 52 . . . cord-014516-r59usk02 329 1 The the DT cord-014516-r59usk02 329 2 gene gene NN cord-014516-r59usk02 329 3 expression expression NN cord-014516-r59usk02 329 4 levels level NNS cord-014516-r59usk02 329 5 in in IN cord-014516-r59usk02 329 6 LV LV NNP cord-014516-r59usk02 329 7 and and CC cord-014516-r59usk02 329 8 PWBC PWBC NNP cord-014516-r59usk02 329 9 were be VBD cord-014516-r59usk02 329 10 compared compare VBN cord-014516-r59usk02 329 11 and and CC cord-014516-r59usk02 329 12 their -PRON- PRP$ cord-014516-r59usk02 329 13 clinical clinical JJ cord-014516-r59usk02 329 14 relationships relationship NNS cord-014516-r59usk02 329 15 were be VBD cord-014516-r59usk02 329 16 evaluated evaluate VBN cord-014516-r59usk02 329 17 . . . cord-014516-r59usk02 330 1 The the DT cord-014516-r59usk02 330 2 diagnostic diagnostic JJ cord-014516-r59usk02 330 3 power power NN cord-014516-r59usk02 330 4 of of IN cord-014516-r59usk02 330 5 the the DT cord-014516-r59usk02 330 6 genetic genetic JJ cord-014516-r59usk02 330 7 expressions expression NNS cord-014516-r59usk02 330 8 in in IN cord-014516-r59usk02 330 9 PWBC PWBC NNP cord-014516-r59usk02 330 10 was be VBD cord-014516-r59usk02 330 11 analyzed analyze VBN cord-014516-r59usk02 330 12 by by IN cord-014516-r59usk02 330 13 comparing compare VBG cord-014516-r59usk02 330 14 to to IN cord-014516-r59usk02 330 15 those those DT cord-014516-r59usk02 330 16 of of IN cord-014516-r59usk02 330 17 33 33 CD cord-014516-r59usk02 330 18 normal normal JJ cord-014516-r59usk02 330 19 dogs dog NNS cord-014516-r59usk02 330 20 . . . cord-014516-r59usk02 331 1 The the DT cord-014516-r59usk02 331 2 levels level NNS cord-014516-r59usk02 331 3 of of IN cord-014516-r59usk02 331 4 all all DT cord-014516-r59usk02 331 5 target target NN cord-014516-r59usk02 331 6 genes gene NNS cord-014516-r59usk02 331 7 expressed express VBN cord-014516-r59usk02 331 8 in in IN cord-014516-r59usk02 331 9 LV LV NNP cord-014516-r59usk02 331 10 and and CC cord-014516-r59usk02 331 11 PWBC PWBC NNP cord-014516-r59usk02 331 12 were be VBD cord-014516-r59usk02 331 13 highly highly RB cord-014516-r59usk02 331 14 correlated correlate VBN cord-014516-r59usk02 331 15 each each DT cord-014516-r59usk02 331 16 other other JJ cord-014516-r59usk02 331 17 in in IN cord-014516-r59usk02 331 18 linear linear JJ cord-014516-r59usk02 331 19 regression regression NN cord-014516-r59usk02 331 20 analysis analysis NN cord-014516-r59usk02 331 21 ( ( -LRB- cord-014516-r59usk02 331 22 p p NN cord-014516-r59usk02 331 23 < < XX cord-014516-r59usk02 331 24 0.0001 0.0001 CD cord-014516-r59usk02 331 25 ; ; : cord-014516-r59usk02 331 26 SERCA2a serca2a NN cord-014516-r59usk02 331 27 , , , cord-014516-r59usk02 332 1 r r LS cord-014516-r59usk02 332 2 = = SYM cord-014516-r59usk02 332 3 0.7425 0.7425 CD cord-014516-r59usk02 332 4 , , , cord-014516-r59usk02 332 5 R r NN cord-014516-r59usk02 332 6 2 2 CD cord-014516-r59usk02 332 7 = = SYM cord-014516-r59usk02 332 8 0.5513 0.5513 CD cord-014516-r59usk02 332 9 ; ; : cord-014516-r59usk02 332 10 PLN PLN NNP cord-014516-r59usk02 332 11 , , , cord-014516-r59usk02 332 12 r r NN cord-014516-r59usk02 332 13 = = SYM cord-014516-r59usk02 332 14 0.7720 0.7720 CD cord-014516-r59usk02 332 15 , , , cord-014516-r59usk02 332 16 R r NN cord-014516-r59usk02 332 17 2 2 CD cord-014516-r59usk02 332 18 = = SYM cord-014516-r59usk02 332 19 0.5959 0.5959 CD cord-014516-r59usk02 332 20 ; ; : cord-014516-r59usk02 332 21 HAX-1 HAX-1 NNP cord-014516-r59usk02 332 22 , , , cord-014516-r59usk02 332 23 r r NN cord-014516-r59usk02 332 24 = = SYM cord-014516-r59usk02 332 25 0.6598 0.6598 CD cord-014516-r59usk02 332 26 , , , cord-014516-r59usk02 332 27 R r NN cord-014516-r59usk02 332 28 2 2 CD cord-014516-r59usk02 332 29 = = SYM cord-014516-r59usk02 332 30 0.4353 0.4353 CD cord-014516-r59usk02 332 31 ) ) -RRB- cord-014516-r59usk02 332 32 , , , cord-014516-r59usk02 332 33 although although IN cord-014516-r59usk02 332 34 LV LV NNP cord-014516-r59usk02 332 35 and and CC cord-014516-r59usk02 332 36 PWBC PWBC NNP cord-014516-r59usk02 332 37 showed show VBD cord-014516-r59usk02 332 38 different different JJ cord-014516-r59usk02 332 39 expression expression NN cord-014516-r59usk02 332 40 levels level NNS cord-014516-r59usk02 332 41 in in IN cord-014516-r59usk02 332 42 a a DT cord-014516-r59usk02 332 43 paired pair VBN cord-014516-r59usk02 332 44 comparison comparison NN cord-014516-r59usk02 332 45 ( ( -LRB- cord-014516-r59usk02 332 46 p p NN cord-014516-r59usk02 332 47 < < XX cord-014516-r59usk02 332 48 0.0001 0.0001 CD cord-014516-r59usk02 332 49 ) ) -RRB- cord-014516-r59usk02 332 50 . . . cord-014516-r59usk02 333 1 According accord VBG cord-014516-r59usk02 333 2 to to IN cord-014516-r59usk02 333 3 the the DT cord-014516-r59usk02 333 4 severity severity NN cord-014516-r59usk02 333 5 of of IN cord-014516-r59usk02 333 6 the the DT cord-014516-r59usk02 333 7 heart heart NN cord-014516-r59usk02 333 8 failure failure NN cord-014516-r59usk02 333 9 ( ( -LRB- cord-014516-r59usk02 333 10 ISACHC ISACHC NNP cord-014516-r59usk02 333 11 ) ) -RRB- cord-014516-r59usk02 333 12 , , , cord-014516-r59usk02 333 13 the the DT cord-014516-r59usk02 333 14 expression expression NN cord-014516-r59usk02 333 15 levels level NNS cord-014516-r59usk02 333 16 of of IN cord-014516-r59usk02 333 17 all all DT cord-014516-r59usk02 333 18 genes gene NNS cord-014516-r59usk02 333 19 were be VBD cord-014516-r59usk02 333 20 gradually gradually RB cord-014516-r59usk02 333 21 and and CC cord-014516-r59usk02 333 22 significantly significantly RB cord-014516-r59usk02 333 23 reduced reduce VBN cord-014516-r59usk02 333 24 in in IN cord-014516-r59usk02 333 25 both both DT cord-014516-r59usk02 333 26 LV LV NNP cord-014516-r59usk02 333 27 and and CC cord-014516-r59usk02 333 28 PWBC PWBC NNP cord-014516-r59usk02 333 29 ( ( -LRB- cord-014516-r59usk02 333 30 p p NN cord-014516-r59usk02 333 31 < < XX cord-014516-r59usk02 333 32 0.01 0.01 CD cord-014516-r59usk02 333 33 ) ) -RRB- cord-014516-r59usk02 333 34 . . . cord-014516-r59usk02 334 1 Especially especially RB cord-014516-r59usk02 334 2 , , , cord-014516-r59usk02 334 3 the the DT cord-014516-r59usk02 334 4 SERCA2a serca2a NN cord-014516-r59usk02 334 5 and and CC cord-014516-r59usk02 334 6 PLN PLN NNP cord-014516-r59usk02 334 7 expressed express VBD cord-014516-r59usk02 334 8 in in IN cord-014516-r59usk02 334 9 PWBC PWBC NNP cord-014516-r59usk02 334 10 could could MD cord-014516-r59usk02 334 11 clearly clearly RB cord-014516-r59usk02 334 12 discriminate discriminate VB cord-014516-r59usk02 334 13 all all DT cord-014516-r59usk02 334 14 ISACHC isachc JJ cord-014516-r59usk02 334 15 groups group NNS cord-014516-r59usk02 334 16 from from IN cord-014516-r59usk02 334 17 the the DT cord-014516-r59usk02 334 18 control control NN cord-014516-r59usk02 334 19 ( ( -LRB- cord-014516-r59usk02 334 20 p p NN cord-014516-r59usk02 334 21 < < XX cord-014516-r59usk02 334 22 0.0001 0.0001 CD cord-014516-r59usk02 334 23 ) ) -RRB- cord-014516-r59usk02 334 24 . . . cord-014516-r59usk02 335 1 Multivariate multivariate JJ cord-014516-r59usk02 335 2 regression regression NN cord-014516-r59usk02 335 3 adjusted adjust VBN cord-014516-r59usk02 335 4 by by IN cord-014516-r59usk02 335 5 age age NN cord-014516-r59usk02 335 6 and and CC cord-014516-r59usk02 335 7 body body NN cord-014516-r59usk02 335 8 weight weight NN cord-014516-r59usk02 335 9 revealed reveal VBD cord-014516-r59usk02 335 10 that that IN cord-014516-r59usk02 335 11 SERCA2a serca2a NN cord-014516-r59usk02 335 12 and and CC cord-014516-r59usk02 335 13 PLN PLN NNP cord-014516-r59usk02 335 14 in in IN cord-014516-r59usk02 335 15 LV LV NNP cord-014516-r59usk02 335 16 were be VBD cord-014516-r59usk02 335 17 negatively negatively RB cord-014516-r59usk02 335 18 associated associate VBN cord-014516-r59usk02 335 19 with with IN cord-014516-r59usk02 335 20 LV LV NNP cord-014516-r59usk02 335 21 internal internal JJ cord-014516-r59usk02 335 22 systolic systolic JJ cord-014516-r59usk02 335 23 dimension dimension NN cord-014516-r59usk02 335 24 ( ( -LRB- cord-014516-r59usk02 335 25 p p NN cord-014516-r59usk02 335 26 = = SYM cord-014516-r59usk02 335 27 0.0251 0.0251 CD cord-014516-r59usk02 335 28 , , , cord-014516-r59usk02 335 29 adjusted adjust VBN cord-014516-r59usk02 335 30 R r NN cord-014516-r59usk02 335 31 2 2 CD cord-014516-r59usk02 335 32 = = SYM cord-014516-r59usk02 335 33 0.524 0.524 CD cord-014516-r59usk02 335 34 and and CC cord-014516-r59usk02 335 35 p p NN cord-014516-r59usk02 335 36 = = SYM cord-014516-r59usk02 335 37 0.012 0.012 CD cord-014516-r59usk02 335 38 , , , cord-014516-r59usk02 335 39 adjusted adjust VBN cord-014516-r59usk02 335 40 R R NNP cord-014516-r59usk02 335 41 2 2 CD cord-014516-r59usk02 335 42 = = SYM cord-014516-r59usk02 335 43 0.530 0.530 CD cord-014516-r59usk02 335 44 , , , cord-014516-r59usk02 335 45 respectively respectively RB cord-014516-r59usk02 335 46 ) ) -RRB- cord-014516-r59usk02 335 47 . . . cord-014516-r59usk02 336 1 PLN PLN NNP cord-014516-r59usk02 336 2 was be VBD cord-014516-r59usk02 336 3 also also RB cord-014516-r59usk02 336 4 negatively negatively RB cord-014516-r59usk02 336 5 related relate VBN cord-014516-r59usk02 336 6 with with IN cord-014516-r59usk02 336 7 LV LV NNP cord-014516-r59usk02 336 8 internal internal JJ cord-014516-r59usk02 336 9 diastolic diastolic JJ cord-014516-r59usk02 336 10 dimension dimension NN cord-014516-r59usk02 336 11 ( ( -LRB- cord-014516-r59usk02 336 12 p p NN cord-014516-r59usk02 336 13 = = SYM cord-014516-r59usk02 336 14 0.037 0.037 CD cord-014516-r59usk02 336 15 , , , cord-014516-r59usk02 336 16 adjusted adjust VBN cord-014516-r59usk02 336 17 R R NNP cord-014516-r59usk02 336 18 2 2 CD cord-014516-r59usk02 336 19 = = SYM cord-014516-r59usk02 336 20 0.573 0.573 CD cord-014516-r59usk02 336 21 ) ) -RRB- cord-014516-r59usk02 336 22 . . . cord-014516-r59usk02 337 1 Additionally additionally RB cord-014516-r59usk02 337 2 , , , cord-014516-r59usk02 337 3 receiver receiver NN cord-014516-r59usk02 337 4 - - HYPH cord-014516-r59usk02 337 5 operating operate VBG cord-014516-r59usk02 337 6 characteristic characteristic JJ cord-014516-r59usk02 337 7 analysis analysis NN cord-014516-r59usk02 337 8 using use VBG cord-014516-r59usk02 337 9 PWBC PWBC NNP cord-014516-r59usk02 337 10 showed show VBD cord-014516-r59usk02 337 11 high high JJ cord-014516-r59usk02 337 12 area area NN cord-014516-r59usk02 337 13 under under IN cord-014516-r59usk02 337 14 the the DT cord-014516-r59usk02 337 15 curve curve NN cord-014516-r59usk02 337 16 ( ( -LRB- cord-014516-r59usk02 337 17 AUC AUC NNP cord-014516-r59usk02 337 18 ) ) -RRB- cord-014516-r59usk02 337 19 values value NNS cord-014516-r59usk02 337 20 for for IN cord-014516-r59usk02 337 21 all all DT cord-014516-r59usk02 337 22 target target NN cord-014516-r59usk02 337 23 genes gene NNS cord-014516-r59usk02 337 24 on on IN cord-014516-r59usk02 337 25 overall overall JJ cord-014516-r59usk02 337 26 ISACHC isachc JJ cord-014516-r59usk02 337 27 groups group NNS cord-014516-r59usk02 337 28 ( ( -LRB- cord-014516-r59usk02 337 29 p p NN cord-014516-r59usk02 337 30 < < XX cord-014516-r59usk02 337 31 0.0001 0.0001 CD cord-014516-r59usk02 337 32 ; ; : cord-014516-r59usk02 337 33 SERCA2a serca2a NN cord-014516-r59usk02 337 34 , , , cord-014516-r59usk02 337 35 AUC=0.9212 AUC=0.9212 NNP cord-014516-r59usk02 337 36 ; ; : cord-014516-r59usk02 337 37 PLN PLN NNP cord-014516-r59usk02 337 38 , , , cord-014516-r59usk02 337 39 AUC=0.8936 auc=0.8936 CD cord-014516-r59usk02 337 40 ; ; : cord-014516-r59usk02 337 41 HAX-1 HAX-1 NNP cord-014516-r59usk02 337 42 , , , cord-014516-r59usk02 337 43 AUC=0.8797 auc=0.8797 CD cord-014516-r59usk02 337 44 ) ) -RRB- cord-014516-r59usk02 337 45 . . . cord-014516-r59usk02 338 1 In in IN cord-014516-r59usk02 338 2 conclusion conclusion NN cord-014516-r59usk02 338 3 , , , cord-014516-r59usk02 338 4 the the DT cord-014516-r59usk02 338 5 transcriptional transcriptional JJ cord-014516-r59usk02 338 6 changes change NNS cord-014516-r59usk02 338 7 of of IN cord-014516-r59usk02 338 8 the the DT cord-014516-r59usk02 338 9 calcium calcium NN cord-014516-r59usk02 338 10 uptake uptake NN cord-014516-r59usk02 338 11 related relate VBN cord-014516-r59usk02 338 12 genes gene NNS cord-014516-r59usk02 338 13 in in IN cord-014516-r59usk02 338 14 PWBC PWBC NNP cord-014516-r59usk02 338 15 may may MD cord-014516-r59usk02 338 16 be be VB cord-014516-r59usk02 338 17 able able JJ cord-014516-r59usk02 338 18 to to TO cord-014516-r59usk02 338 19 reflect reflect VB cord-014516-r59usk02 338 20 myocardial myocardial JJ cord-014516-r59usk02 338 21 hemodynamic hemodynamic JJ cord-014516-r59usk02 338 22 stress stress NN cord-014516-r59usk02 338 23 as as RB cord-014516-r59usk02 338 24 well well RB cord-014516-r59usk02 338 25 as as IN cord-014516-r59usk02 338 26 to to TO cord-014516-r59usk02 338 27 be be VB cord-014516-r59usk02 338 28 utilized utilize VBN cord-014516-r59usk02 338 29 as as IN cord-014516-r59usk02 338 30 promising promise VBG cord-014516-r59usk02 338 31 cardiac cardiac JJ cord-014516-r59usk02 338 32 biomarkers biomarker NNS cord-014516-r59usk02 338 33 . . . cord-014516-r59usk02 339 1 No no DT cord-014516-r59usk02 339 2 conflicts conflict NNS cord-014516-r59usk02 339 3 of of IN cord-014516-r59usk02 339 4 interest interest NN cord-014516-r59usk02 339 5 reported report VBN cord-014516-r59usk02 339 6 . . . cord-014516-r59usk02 340 1 The the DT cord-014516-r59usk02 340 2 aim aim NN cord-014516-r59usk02 340 3 of of IN cord-014516-r59usk02 340 4 this this DT cord-014516-r59usk02 340 5 study study NN cord-014516-r59usk02 340 6 was be VBD cord-014516-r59usk02 340 7 to to TO cord-014516-r59usk02 340 8 estimate estimate VB cord-014516-r59usk02 340 9 heart heart NN cord-014516-r59usk02 340 10 - - HYPH cord-014516-r59usk02 340 11 rate rate NN cord-014516-r59usk02 340 12 normalized normalize VBN cord-014516-r59usk02 340 13 pulmonary pulmonary JJ cord-014516-r59usk02 340 14 transit transit NN cord-014516-r59usk02 340 15 times time NNS cord-014516-r59usk02 340 16 ( ( -LRB- cord-014516-r59usk02 340 17 nPTT nPTT NNP cord-014516-r59usk02 340 18 ) ) -RRB- cord-014516-r59usk02 340 19 in in IN cord-014516-r59usk02 340 20 cardiomyopathic cardiomyopathic NNP cord-014516-r59usk02 340 21 cats cat NNS cord-014516-r59usk02 340 22 with with IN cord-014516-r59usk02 340 23 or or CC cord-014516-r59usk02 340 24 without without IN cord-014516-r59usk02 340 25 congestive congestive JJ cord-014516-r59usk02 340 26 heart heart NN cord-014516-r59usk02 340 27 failure failure NN cord-014516-r59usk02 340 28 ( ( -LRB- cord-014516-r59usk02 340 29 CHF CHF NNP cord-014516-r59usk02 340 30 ) ) -RRB- cord-014516-r59usk02 340 31 , , , cord-014516-r59usk02 340 32 to to TO cord-014516-r59usk02 340 33 assess assess VB cord-014516-r59usk02 340 34 potential potential JJ cord-014516-r59usk02 340 35 associations association NNS cord-014516-r59usk02 340 36 of of IN cord-014516-r59usk02 340 37 echocardiographic echocardiographic JJ cord-014516-r59usk02 340 38 variables variable NNS cord-014516-r59usk02 340 39 and and CC cord-014516-r59usk02 340 40 nPTT nptt NN cord-014516-r59usk02 340 41 , , , cord-014516-r59usk02 340 42 and and CC cord-014516-r59usk02 340 43 to to TO cord-014516-r59usk02 340 44 evaluate evaluate VB cord-014516-r59usk02 340 45 nPTT nptt XX cord-014516-r59usk02 340 46 as as IN cord-014516-r59usk02 340 47 a a DT cord-014516-r59usk02 340 48 test test NN cord-014516-r59usk02 340 49 for for IN cord-014516-r59usk02 340 50 presence presence NN cord-014516-r59usk02 340 51 of of IN cord-014516-r59usk02 340 52 CHF CHF NNP cord-014516-r59usk02 340 53 . . . cord-014516-r59usk02 341 1 48 48 CD cord-014516-r59usk02 341 2 privately privately RB cord-014516-r59usk02 341 3 owned own VBN cord-014516-r59usk02 341 4 cats cat NNS cord-014516-r59usk02 341 5 were be VBD cord-014516-r59usk02 341 6 included include VBN cord-014516-r59usk02 341 7 . . . cord-014516-r59usk02 342 1 nPTT nPTT NNP cord-014516-r59usk02 342 2 was be VBD cord-014516-r59usk02 342 3 measured measure VBN cord-014516-r59usk02 342 4 using use VBG cord-014516-r59usk02 342 5 echocardiography echocardiography NN cord-014516-r59usk02 342 6 and and CC cord-014516-r59usk02 342 7 the the DT cord-014516-r59usk02 342 8 ultrasound ultrasound NN cord-014516-r59usk02 342 9 contrast contrast NN cord-014516-r59usk02 342 10 media medium NNS cord-014516-r59usk02 343 1 Sonovue Sonovue NNP cord-014516-r59usk02 343 2 â â : cord-014516-r59usk02 343 3 in in IN cord-014516-r59usk02 343 4 3 3 CD cord-014516-r59usk02 343 5 groups group NNS cord-014516-r59usk02 343 6 of of IN cord-014516-r59usk02 343 7 cats cat NNS cord-014516-r59usk02 343 8 : : : cord-014516-r59usk02 343 9 healthy healthy JJ cord-014516-r59usk02 343 10 cats cat NNS cord-014516-r59usk02 343 11 ( ( -LRB- cord-014516-r59usk02 343 12 Group group NN cord-014516-r59usk02 343 13 1 1 CD cord-014516-r59usk02 343 14 ) ) -RRB- cord-014516-r59usk02 343 15 , , , cord-014516-r59usk02 343 16 cats cat NNS cord-014516-r59usk02 343 17 with with IN cord-014516-r59usk02 343 18 cardiomyopathy cardiomyopathy NN cord-014516-r59usk02 343 19 ( ( -LRB- cord-014516-r59usk02 343 20 CM cm NN cord-014516-r59usk02 343 21 ) ) -RRB- cord-014516-r59usk02 344 1 but but CC cord-014516-r59usk02 344 2 without without IN cord-014516-r59usk02 344 3 CHF CHF NNP cord-014516-r59usk02 344 4 ( ( -LRB- cord-014516-r59usk02 344 5 Group Group NNP cord-014516-r59usk02 344 6 2 2 CD cord-014516-r59usk02 344 7 ) ) -RRB- cord-014516-r59usk02 344 8 , , , cord-014516-r59usk02 344 9 and and CC cord-014516-r59usk02 344 10 cats cat NNS cord-014516-r59usk02 344 11 with with IN cord-014516-r59usk02 344 12 CM CM NNP cord-014516-r59usk02 344 13 and and CC cord-014516-r59usk02 344 14 CHF CHF NNP cord-014516-r59usk02 344 15 ( ( -LRB- cord-014516-r59usk02 344 16 Group Group NNP cord-014516-r59usk02 344 17 3 3 CD cord-014516-r59usk02 344 18 ) ) -RRB- cord-014516-r59usk02 344 19 . . . cord-014516-r59usk02 345 1 Receiver receiver NN cord-014516-r59usk02 345 2 operating operate VBG cord-014516-r59usk02 345 3 characteristic characteristic JJ cord-014516-r59usk02 345 4 curves curve NNS cord-014516-r59usk02 345 5 ( ( -LRB- cord-014516-r59usk02 345 6 ROC ROC NNP cord-014516-r59usk02 345 7 ) ) -RRB- cord-014516-r59usk02 345 8 were be VBD cord-014516-r59usk02 345 9 created create VBN cord-014516-r59usk02 345 10 for for IN cord-014516-r59usk02 345 11 nPTT nptt FW cord-014516-r59usk02 345 12 , , , cord-014516-r59usk02 345 13 left leave VBN cord-014516-r59usk02 345 14 atrial atrial JJ cord-014516-r59usk02 345 15 diameter diameter NN cord-014516-r59usk02 345 16 ( ( -LRB- cord-014516-r59usk02 345 17 LAD LAD NNP cord-014516-r59usk02 345 18 ) ) -RRB- cord-014516-r59usk02 345 19 and and CC cord-014516-r59usk02 345 20 the the DT cord-014516-r59usk02 345 21 left left JJ cord-014516-r59usk02 345 22 atrial atrial NN cord-014516-r59usk02 345 23 to to IN cord-014516-r59usk02 345 24 aortic aortic JJ cord-014516-r59usk02 345 25 root root NN cord-014516-r59usk02 345 26 ratio ratio NN cord-014516-r59usk02 345 27 ( ( -LRB- cord-014516-r59usk02 345 28 LA la NN cord-014516-r59usk02 345 29 : : : cord-014516-r59usk02 345 30 AO AO NNP cord-014516-r59usk02 345 31 ) ) -RRB- cord-014516-r59usk02 345 32 to to TO cord-014516-r59usk02 345 33 assess assess VB cord-014516-r59usk02 345 34 and and CC cord-014516-r59usk02 345 35 compare compare VB cord-014516-r59usk02 345 36 their -PRON- PRP$ cord-014516-r59usk02 345 37 usefulness usefulness NN cord-014516-r59usk02 345 38 as as IN cord-014516-r59usk02 345 39 tests test NNS cord-014516-r59usk02 345 40 for for IN cord-014516-r59usk02 345 41 presence presence NN cord-014516-r59usk02 345 42 of of IN cord-014516-r59usk02 345 43 CHF CHF NNP cord-014516-r59usk02 345 44 . . . cord-014516-r59usk02 346 1 Interrelations interrelation NNS cord-014516-r59usk02 346 2 between between IN cord-014516-r59usk02 346 3 pulmonary pulmonary JJ cord-014516-r59usk02 346 4 blood blood NN cord-014516-r59usk02 346 5 volume volume NN cord-014516-r59usk02 346 6 ( ( -LRB- cord-014516-r59usk02 346 7 PBV PBV NNP cord-014516-r59usk02 346 8 ) ) -RRB- cord-014516-r59usk02 346 9 , , , cord-014516-r59usk02 346 10 nPTT nptt NN cord-014516-r59usk02 346 11 , , , cord-014516-r59usk02 346 12 stroke stroke NN cord-014516-r59usk02 346 13 volume volume NN cord-014516-r59usk02 346 14 ( ( -LRB- cord-014516-r59usk02 346 15 SV SV NNP cord-014516-r59usk02 346 16 ) ) -RRB- cord-014516-r59usk02 346 17 and and CC cord-014516-r59usk02 346 18 echocardiographic echocardiographic JJ cord-014516-r59usk02 346 19 variables variable NNS cord-014516-r59usk02 346 20 were be VBD cord-014516-r59usk02 346 21 investigated investigate VBN cord-014516-r59usk02 346 22 by by IN cord-014516-r59usk02 346 23 means mean NNS cord-014516-r59usk02 346 24 of of IN cord-014516-r59usk02 346 25 uni uni JJ cord-014516-r59usk02 346 26 - - HYPH cord-014516-r59usk02 346 27 and and CC cord-014516-r59usk02 346 28 multivariate multivariate JJ cord-014516-r59usk02 346 29 analysis analysis NN cord-014516-r59usk02 346 30 . . . cord-014516-r59usk02 347 1 nPTT nptt FW cord-014516-r59usk02 347 2 values value NNS cord-014516-r59usk02 347 3 in in IN cord-014516-r59usk02 347 4 group group NN cord-014516-r59usk02 347 5 1 1 CD cord-014516-r59usk02 347 6 , , , cord-014516-r59usk02 347 7 group group NN cord-014516-r59usk02 347 8 2 2 CD cord-014516-r59usk02 347 9 and and CC cord-014516-r59usk02 347 10 group group NN cord-014516-r59usk02 347 11 3 3 CD cord-014516-r59usk02 347 12 were be VBD cord-014516-r59usk02 347 13 3.63 3.63 CD cord-014516-r59usk02 347 14 ( ( -LRB- cord-014516-r59usk02 347 15 interquartile interquartile JJ cord-014516-r59usk02 347 16 range range NN cord-014516-r59usk02 347 17 ( ( -LRB- cord-014516-r59usk02 347 18 IQR iqr NN cord-014516-r59usk02 347 19 ) ) -RRB- cord-014516-r59usk02 348 1 3.20 3.20 CD cord-014516-r59usk02 348 2 - - SYM cord-014516-r59usk02 348 3 4.22 4.22 CD cord-014516-r59usk02 348 4 ) ) -RRB- cord-014516-r59usk02 348 5 , , . cord-014516-r59usk02 349 1 6.09 6.09 CD cord-014516-r59usk02 349 2 ( ( -LRB- cord-014516-r59usk02 349 3 IQR IQR NNP cord-014516-r59usk02 349 4 5.0 5.0 CD cord-014516-r59usk02 349 5 - - HYPH cord-014516-r59usk02 349 6 7.02 7.02 CD cord-014516-r59usk02 349 7 ) ) -RRB- cord-014516-r59usk02 349 8 , , , cord-014516-r59usk02 349 9 and and CC cord-014516-r59usk02 349 10 8.49 8.49 CD cord-014516-r59usk02 349 11 ( ( -LRB- cord-014516-r59usk02 349 12 IQR IQR NNP cord-014516-r59usk02 349 13 7.58 7.58 CD cord-014516-r59usk02 349 14 - - : cord-014516-r59usk02 349 15 11.04 11.04 CD cord-014516-r59usk02 349 16 ) ) -RRB- cord-014516-r59usk02 349 17 , , , cord-014516-r59usk02 349 18 respectively respectively RB cord-014516-r59usk02 349 19 . . . cord-014516-r59usk02 350 1 Values value NNS cord-014516-r59usk02 350 2 were be VBD cord-014516-r59usk02 350 3 significantly significantly RB cord-014516-r59usk02 350 4 different different JJ cord-014516-r59usk02 350 5 between between IN cord-014516-r59usk02 350 6 all all DT cord-014516-r59usk02 350 7 3 3 CD cord-014516-r59usk02 350 8 groups group NNS cord-014516-r59usk02 350 9 . . . cord-014516-r59usk02 351 1 Pulmonary pulmonary JJ cord-014516-r59usk02 351 2 blood blood NN cord-014516-r59usk02 351 3 volumes volume NNS cord-014516-r59usk02 351 4 in in IN cord-014516-r59usk02 351 5 group group NN cord-014516-r59usk02 351 6 1 1 CD cord-014516-r59usk02 351 7 , , , cord-014516-r59usk02 351 8 group group NN cord-014516-r59usk02 351 9 2 2 CD cord-014516-r59usk02 351 10 , , , cord-014516-r59usk02 351 11 and and CC cord-014516-r59usk02 351 12 group group NN cord-014516-r59usk02 351 13 3 3 CD cord-014516-r59usk02 351 14 were be VBD cord-014516-r59usk02 351 15 27.94 27.94 CD cord-014516-r59usk02 351 16 ml ml NNS cord-014516-r59usk02 352 1 ( ( -LRB- cord-014516-r59usk02 352 2 IQR IQR NNP cord-014516-r59usk02 352 3 21.02 21.02 CD cord-014516-r59usk02 352 4 ml-33.17 ml-33.17 NNP cord-014516-r59usk02 352 5 ml ml NNP cord-014516-r59usk02 352 6 ) ) -RRB- cord-014516-r59usk02 352 7 , , , cord-014516-r59usk02 352 8 42.83 42.83 CD cord-014516-r59usk02 352 9 ml ml NN cord-014516-r59usk02 352 10 ( ( -LRB- cord-014516-r59usk02 352 11 IQR IQR NNP cord-014516-r59usk02 352 12 38.46 38.46 CD cord-014516-r59usk02 352 13 ml-50.36 ml-50.36 NNP cord-014516-r59usk02 352 14 ml ml NNP cord-014516-r59usk02 352 15 ) ) -RRB- cord-014516-r59usk02 352 16 and and CC cord-014516-r59usk02 352 17 49.48 49.48 CD cord-014516-r59usk02 352 18 ml ml NN cord-014516-r59usk02 352 19 ( ( -LRB- cord-014516-r59usk02 352 20 IQR IQR NNP cord-014516-r59usk02 352 21 38.84 38.84 CD cord-014516-r59usk02 352 22 ml-64.39 ml-64.39 NNP cord-014516-r59usk02 352 23 ml ml NNP cord-014516-r59usk02 352 24 ) ) -RRB- cord-014516-r59usk02 352 25 . . . cord-014516-r59usk02 353 1 SV SV NNP cord-014516-r59usk02 353 2 , , , cord-014516-r59usk02 353 3 PBV PBV NNP cord-014516-r59usk02 353 4 and and CC cord-014516-r59usk02 353 5 shortening shorten VBG cord-014516-r59usk02 353 6 fraction fraction NN cord-014516-r59usk02 353 7 < < XX cord-014516-r59usk02 353 8 30 30 CD cord-014516-r59usk02 353 9 % % NN cord-014516-r59usk02 353 10 were be VBD cord-014516-r59usk02 353 11 significant significant JJ cord-014516-r59usk02 353 12 predictors predictor NNS cord-014516-r59usk02 353 13 of of IN cord-014516-r59usk02 353 14 nPTT nptt NN cord-014516-r59usk02 353 15 . . . cord-014516-r59usk02 354 1 NPTT NPTT NNP cord-014516-r59usk02 354 2 and and CC cord-014516-r59usk02 354 3 LA LA NNP cord-014516-r59usk02 354 4 : : : cord-014516-r59usk02 354 5 AO AO NNP cord-014516-r59usk02 354 6 ratio ratio NN cord-014516-r59usk02 354 7 , , , cord-014516-r59usk02 354 8 not not RB cord-014516-r59usk02 354 9 SV SV NNP cord-014516-r59usk02 354 10 were be VBD cord-014516-r59usk02 354 11 the the DT cord-014516-r59usk02 354 12 main main JJ cord-014516-r59usk02 354 13 predictors predictor NNS cord-014516-r59usk02 354 14 of of IN cord-014516-r59usk02 354 15 PBV PBV NNP cord-014516-r59usk02 354 16 . . . cord-014516-r59usk02 355 1 Analyzing analyze VBG cord-014516-r59usk02 355 2 ROC ROC NNP cord-014516-r59usk02 355 3 for for IN cord-014516-r59usk02 355 4 nPTT nptt NN cord-014516-r59usk02 355 5 as as IN cord-014516-r59usk02 355 6 a a DT cord-014516-r59usk02 355 7 clinical clinical JJ cord-014516-r59usk02 355 8 test test NN cord-014516-r59usk02 355 9 for for IN cord-014516-r59usk02 355 10 CHF CHF NNP cord-014516-r59usk02 355 11 yielded yield VBD cord-014516-r59usk02 355 12 an an DT cord-014516-r59usk02 355 13 AUC AUC NNP cord-014516-r59usk02 355 14 of of IN cord-014516-r59usk02 355 15 0.956 0.956 CD cord-014516-r59usk02 355 16 which which WDT cord-014516-r59usk02 355 17 was be VBD cord-014516-r59usk02 355 18 similar similar JJ cord-014516-r59usk02 355 19 for for IN cord-014516-r59usk02 355 20 LA LA NNP cord-014516-r59usk02 355 21 : : : cord-014516-r59usk02 355 22 AO AO NNP cord-014516-r59usk02 355 23 ratio ratio NN cord-014516-r59usk02 355 24 . . . cord-014516-r59usk02 356 1 nPTT nPTT NNP cord-014516-r59usk02 356 2 may may MD cord-014516-r59usk02 356 3 be be VB cord-014516-r59usk02 356 4 useful useful JJ cord-014516-r59usk02 356 5 test test NN cord-014516-r59usk02 356 6 for for IN cord-014516-r59usk02 356 7 the the DT cord-014516-r59usk02 356 8 presence presence NN cord-014516-r59usk02 356 9 of of IN cord-014516-r59usk02 356 10 CHF CHF NNP cord-014516-r59usk02 356 11 in in IN cord-014516-r59usk02 356 12 cats cat NNS cord-014516-r59usk02 356 13 with with IN cord-014516-r59usk02 356 14 CM CM NNP cord-014516-r59usk02 356 15 and and CC cord-014516-r59usk02 356 16 as as IN cord-014516-r59usk02 356 17 a a DT cord-014516-r59usk02 356 18 measure measure NN cord-014516-r59usk02 356 19 of of IN cord-014516-r59usk02 356 20 cardiac cardiac JJ cord-014516-r59usk02 356 21 performance performance NN cord-014516-r59usk02 356 22 . . . cord-014516-r59usk02 357 1 nPTT nPTT NNP cord-014516-r59usk02 357 2 and and CC cord-014516-r59usk02 357 3 LA la NN cord-014516-r59usk02 357 4 : : : cord-014516-r59usk02 357 5 AO AO NNP cord-014516-r59usk02 357 6 ratios ratio NNS cord-014516-r59usk02 357 7 predict predict VBP cord-014516-r59usk02 357 8 CHF CHF NNP cord-014516-r59usk02 357 9 with with IN cord-014516-r59usk02 357 10 equal equal JJ cord-014516-r59usk02 357 11 accuracy accuracy NN cord-014516-r59usk02 357 12 . . . cord-014516-r59usk02 358 1 Increased Increased NNP cord-014516-r59usk02 358 2 PBV PBV NNP cord-014516-r59usk02 358 3 is be VBZ cord-014516-r59usk02 358 4 significantly significantly RB cord-014516-r59usk02 358 5 associated associate VBN cord-014516-r59usk02 358 6 with with IN cord-014516-r59usk02 358 7 higher high JJR cord-014516-r59usk02 358 8 nPTT nptt NN cord-014516-r59usk02 358 9 and and CC cord-014516-r59usk02 358 10 LA la NN cord-014516-r59usk02 358 11 : : : cord-014516-r59usk02 358 12 AO AO NNP cord-014516-r59usk02 358 13 ratios ratio NNS cord-014516-r59usk02 358 14 . . . cord-014516-r59usk02 359 1 Both both DT cord-014516-r59usk02 359 2 decreased decrease VBD cord-014516-r59usk02 359 3 SV SV NNP cord-014516-r59usk02 359 4 and and CC cord-014516-r59usk02 359 5 increased increase VBD cord-014516-r59usk02 359 6 PBV PBV NNP cord-014516-r59usk02 359 7 explain explain VBP cord-014516-r59usk02 359 8 the the DT cord-014516-r59usk02 359 9 increased increase VBN cord-014516-r59usk02 359 10 nPTT nptt NN cord-014516-r59usk02 359 11 in in IN cord-014516-r59usk02 359 12 cardiomyopathic cardiomyopathic JJ cord-014516-r59usk02 359 13 cats cat NNS cord-014516-r59usk02 359 14 . . . cord-014516-r59usk02 360 1 The the DT cord-014516-r59usk02 360 2 author author NN cord-014516-r59usk02 360 3 received receive VBD cord-014516-r59usk02 360 4 a a DT cord-014516-r59usk02 360 5 travel travel NN cord-014516-r59usk02 360 6 scholarship scholarship NN cord-014516-r59usk02 360 7 from from IN cord-014516-r59usk02 360 8 Zoetis Zoetis NNP cord-014516-r59usk02 360 9 to to TO cord-014516-r59usk02 360 10 attend attend VB cord-014516-r59usk02 360 11 this this DT cord-014516-r59usk02 360 12 congress congress NNP cord-014516-r59usk02 360 13 . . . cord-014516-r59usk02 361 1 Acute acute JJ cord-014516-r59usk02 361 2 arterial arterial JJ cord-014516-r59usk02 361 3 thromboembolism thromboembolism NN cord-014516-r59usk02 361 4 ( ( -LRB- cord-014516-r59usk02 361 5 AATE AATE NNP cord-014516-r59usk02 361 6 ) ) -RRB- cord-014516-r59usk02 361 7 occurs occur VBZ cord-014516-r59usk02 361 8 commonly commonly RB cord-014516-r59usk02 361 9 in in IN cord-014516-r59usk02 361 10 cats cat NNS cord-014516-r59usk02 361 11 , , , cord-014516-r59usk02 361 12 and and CC cord-014516-r59usk02 361 13 less less RBR cord-014516-r59usk02 361 14 frequently frequently RB cord-014516-r59usk02 361 15 in in IN cord-014516-r59usk02 361 16 dogs dog NNS cord-014516-r59usk02 361 17 , , , cord-014516-r59usk02 361 18 mostly mostly RB cord-014516-r59usk02 361 19 resulting result VBG cord-014516-r59usk02 361 20 in in IN cord-014516-r59usk02 361 21 limb limb NN cord-014516-r59usk02 361 22 paresis paresis NN cord-014516-r59usk02 361 23 or or CC cord-014516-r59usk02 361 24 paralysis paralysis NN cord-014516-r59usk02 361 25 . . . cord-014516-r59usk02 362 1 Diagnosis diagnosis NN cord-014516-r59usk02 362 2 is be VBZ cord-014516-r59usk02 362 3 based base VBN cord-014516-r59usk02 362 4 typically typically RB cord-014516-r59usk02 362 5 on on IN cord-014516-r59usk02 362 6 physical physical JJ cord-014516-r59usk02 362 7 examination examination NN cord-014516-r59usk02 362 8 and and CC cord-014516-r59usk02 362 9 advanced advanced JJ cord-014516-r59usk02 362 10 imaging imaging NN cord-014516-r59usk02 362 11 . . . cord-014516-r59usk02 363 1 Diminished diminished JJ cord-014516-r59usk02 363 2 affected affected JJ cord-014516-r59usk02 363 3 - - HYPH cord-014516-r59usk02 363 4 limb limb NN cord-014516-r59usk02 363 5 peripheral peripheral JJ cord-014516-r59usk02 363 6 blood blood NN cord-014516-r59usk02 363 7 flow flow NN cord-014516-r59usk02 363 8 induces induce VBZ cord-014516-r59usk02 363 9 changes change NNS cord-014516-r59usk02 363 10 in in IN cord-014516-r59usk02 363 11 several several JJ cord-014516-r59usk02 363 12 analytes analyte NNS cord-014516-r59usk02 363 13 concentrations concentration NNS cord-014516-r59usk02 363 14 in in IN cord-014516-r59usk02 363 15 affected affected JJ cord-014516-r59usk02 363 16 limb limb NN cord-014516-r59usk02 363 17 venous venous JJ cord-014516-r59usk02 363 18 samples sample NNS cord-014516-r59usk02 363 19 , , , cord-014516-r59usk02 363 20 compared compare VBN cord-014516-r59usk02 363 21 to to IN cord-014516-r59usk02 363 22 their -PRON- PRP$ cord-014516-r59usk02 363 23 peripheral peripheral JJ cord-014516-r59usk02 363 24 venous venous JJ cord-014516-r59usk02 363 25 concentration concentration NN cord-014516-r59usk02 363 26 . . . cord-014516-r59usk02 364 1 We -PRON- PRP cord-014516-r59usk02 364 2 hypothesized hypothesize VBD cord-014516-r59usk02 364 3 that that IN cord-014516-r59usk02 364 4 in in IN cord-014516-r59usk02 364 5 AATE AATE NNP cord-014516-r59usk02 364 6 , , , cord-014516-r59usk02 364 7 local local JJ cord-014516-r59usk02 364 8 , , , cord-014516-r59usk02 364 9 affected affected JJ cord-014516-r59usk02 364 10 - - HYPH cord-014516-r59usk02 364 11 limb limb NN cord-014516-r59usk02 364 12 venous venous JJ cord-014516-r59usk02 364 13 glucose glucose NN cord-014516-r59usk02 364 14 concentration concentration NN cord-014516-r59usk02 364 15 decreases decrease VBZ cord-014516-r59usk02 364 16 below below IN cord-014516-r59usk02 364 17 reference reference NN cord-014516-r59usk02 364 18 interval interval NN cord-014516-r59usk02 364 19 , , , cord-014516-r59usk02 364 20 while while IN cord-014516-r59usk02 364 21 systemic systemic JJ cord-014516-r59usk02 364 22 glucose glucose NN cord-014516-r59usk02 364 23 concentration concentration NN cord-014516-r59usk02 364 24 remains remain VBZ cord-014516-r59usk02 364 25 unaffected unaffected JJ cord-014516-r59usk02 364 26 . . . cord-014516-r59usk02 365 1 The the DT cord-014516-r59usk02 365 2 study study NN cord-014516-r59usk02 365 3 included include VBD cord-014516-r59usk02 365 4 3 3 CD cord-014516-r59usk02 365 5 groups group NNS cord-014516-r59usk02 365 6 for for IN cord-014516-r59usk02 365 7 each each DT cord-014516-r59usk02 365 8 species species NN cord-014516-r59usk02 365 9 : : : cord-014516-r59usk02 365 10 paralytic paralytic JJ cord-014516-r59usk02 365 11 AATE AATE NNP cord-014516-r59usk02 365 12 cases case NNS cord-014516-r59usk02 365 13 , , , cord-014516-r59usk02 365 14 non non JJ cord-014516-r59usk02 365 15 - - JJ cord-014516-r59usk02 365 16 ambulatory ambulatory JJ cord-014516-r59usk02 365 17 controls control NNS cord-014516-r59usk02 365 18 with with IN cord-014516-r59usk02 365 19 limb limb NN cord-014516-r59usk02 365 20 paralysis paralysis NN cord-014516-r59usk02 365 21 of of IN cord-014516-r59usk02 365 22 orthopedic orthopedic JJ cord-014516-r59usk02 365 23 or or CC cord-014516-r59usk02 365 24 neurologic neurologic JJ cord-014516-r59usk02 365 25 disorders disorder NNS cord-014516-r59usk02 365 26 , , , cord-014516-r59usk02 365 27 and and CC cord-014516-r59usk02 365 28 ambulatory ambulatory JJ cord-014516-r59usk02 365 29 controls control NNS cord-014516-r59usk02 365 30 diagnosed diagnose VBN cord-014516-r59usk02 365 31 with with IN cord-014516-r59usk02 365 32 various various JJ cord-014516-r59usk02 365 33 diseases disease NNS cord-014516-r59usk02 365 34 . . . cord-014516-r59usk02 366 1 Systemic systemic JJ cord-014516-r59usk02 366 2 and and CC cord-014516-r59usk02 366 3 peripheral peripheral JJ cord-014516-r59usk02 366 4 , , , cord-014516-r59usk02 366 5 affected affected JJ cord-014516-r59usk02 366 6 - - HYPH cord-014516-r59usk02 366 7 limb limb NN cord-014516-r59usk02 366 8 blood blood NN cord-014516-r59usk02 366 9 glucose glucose NN cord-014516-r59usk02 366 10 concentrations concentration NNS cord-014516-r59usk02 366 11 were be VBD cord-014516-r59usk02 366 12 measured measure VBN cord-014516-r59usk02 366 13 . . . cord-014516-r59usk02 367 1 Group group NN cord-014516-r59usk02 367 2 absolute absolute NN cord-014516-r59usk02 367 3 ( ( -LRB- cord-014516-r59usk02 367 4 DGlu DGlu NNP cord-014516-r59usk02 367 5 ) ) -RRB- cord-014516-r59usk02 367 6 and and CC cord-014516-r59usk02 367 7 relative relative JJ cord-014516-r59usk02 367 8 ( ( -LRB- cord-014516-r59usk02 367 9 % % NN cord-014516-r59usk02 367 10 DGlu DGlu NNP cord-014516-r59usk02 367 11 ) ) -RRB- cord-014516-r59usk02 367 12 differences difference NNS cord-014516-r59usk02 367 13 were be VBD cord-014516-r59usk02 367 14 compared compare VBN cord-014516-r59usk02 367 15 . . . cord-014516-r59usk02 368 1 No no DT cord-014516-r59usk02 368 2 procedure procedure NN cord-014516-r59usk02 368 3 - - HYPH cord-014516-r59usk02 368 4 associated associate VBN cord-014516-r59usk02 368 5 complications complication NNS cord-014516-r59usk02 368 6 or or CC cord-014516-r59usk02 368 7 pain pain NN cord-014516-r59usk02 368 8 were be VBD cord-014516-r59usk02 368 9 noted note VBN cord-014516-r59usk02 368 10 . . . cord-014516-r59usk02 369 1 Peripheral peripheral JJ cord-014516-r59usk02 369 2 blood blood NN cord-014516-r59usk02 369 3 glucose glucose NN cord-014516-r59usk02 369 4 concentrations concentration NNS cord-014516-r59usk02 369 5 were be VBD cord-014516-r59usk02 369 6 decreased decrease VBN cord-014516-r59usk02 369 7 ( ( -LRB- cord-014516-r59usk02 369 8 P p NN cord-014516-r59usk02 369 9 ≤ ≤ NN cord-014516-r59usk02 369 10 0.006 0.006 CD cord-014516-r59usk02 369 11 ) ) -RRB- cord-014516-r59usk02 369 12 only only RB cord-014516-r59usk02 369 13 in in IN cord-014516-r59usk02 369 14 cats cat NNS cord-014516-r59usk02 369 15 and and CC cord-014516-r59usk02 369 16 dogs dog NNS cord-014516-r59usk02 369 17 with with IN cord-014516-r59usk02 369 18 AATE AATE NNP cord-014516-r59usk02 369 19 . . . cord-014516-r59usk02 370 1 DGlu DGlu NNP cord-014516-r59usk02 370 2 and and CC cord-014516-r59usk02 370 3 % % NN cord-014516-r59usk02 370 4 DGlu DGlu NNPS cord-014516-r59usk02 370 5 were be VBD cord-014516-r59usk02 370 6 higher high JJR cord-014516-r59usk02 370 7 in in IN cord-014516-r59usk02 370 8 the the DT cord-014516-r59usk02 370 9 AATE AATE NNP cord-014516-r59usk02 370 10 groups group NNS cord-014516-r59usk02 370 11 in in IN cord-014516-r59usk02 370 12 both both DT cord-014516-r59usk02 370 13 cats cat NNS cord-014516-r59usk02 370 14 and and CC cord-014516-r59usk02 370 15 dogs dog NNS cord-014516-r59usk02 370 16 compared compare VBN cord-014516-r59usk02 370 17 to to IN cord-014516-r59usk02 370 18 their -PRON- PRP$ cord-014516-r59usk02 370 19 respective respective JJ cord-014516-r59usk02 370 20 control control NN cord-014516-r59usk02 370 21 groups group NNS cord-014516-r59usk02 370 22 ( ( -LRB- cord-014516-r59usk02 370 23 P p NN cord-014516-r59usk02 370 24 < < XX cord-014516-r59usk02 370 25 0.0001 0.0001 CD cord-014516-r59usk02 370 26 , , , cord-014516-r59usk02 370 27 P p NN cord-014516-r59usk02 370 28 < < XX cord-014516-r59usk02 370 29 0.001 0.001 CD cord-014516-r59usk02 370 30 , , , cord-014516-r59usk02 370 31 respectively respectively RB cord-014516-r59usk02 370 32 ) ) -RRB- cord-014516-r59usk02 370 33 , , , cord-014516-r59usk02 370 34 with with IN cord-014516-r59usk02 370 35 no no DT cord-014516-r59usk02 370 36 differences difference NNS cord-014516-r59usk02 370 37 between between IN cord-014516-r59usk02 370 38 the the DT cord-014516-r59usk02 370 39 control control NN cord-014516-r59usk02 370 40 groups group NNS cord-014516-r59usk02 370 41 . . . cord-014516-r59usk02 371 1 Receiver receiver NN cord-014516-r59usk02 371 2 operator operator NN cord-014516-r59usk02 371 3 characteristics characteristic NNS cord-014516-r59usk02 371 4 analysis analysis NN cord-014516-r59usk02 371 5 of of IN cord-014516-r59usk02 371 6 DGlu DGlu NNP cord-014516-r59usk02 371 7 and and CC cord-014516-r59usk02 371 8 % % NN cord-014516-r59usk02 371 9 DGlu DGlu NNP cord-014516-r59usk02 371 10 as as IN cord-014516-r59usk02 371 11 predictors predictor NNS cord-014516-r59usk02 371 12 of of IN cord-014516-r59usk02 371 13 AATE AATE NNP cord-014516-r59usk02 371 14 in in IN cord-014516-r59usk02 371 15 cats cat NNS cord-014516-r59usk02 371 16 had have VBD cord-014516-r59usk02 371 17 areas area NNS cord-014516-r59usk02 371 18 under under IN cord-014516-r59usk02 371 19 the the DT cord-014516-r59usk02 371 20 curve curve NN cord-014516-r59usk02 371 21 of of IN cord-014516-r59usk02 371 22 0.96 0.96 CD cord-014516-r59usk02 371 23 and and CC cord-014516-r59usk02 371 24 1.00 1.00 CD cord-014516-r59usk02 371 25 , , , cord-014516-r59usk02 371 26 respectively respectively RB cord-014516-r59usk02 371 27 , , , cord-014516-r59usk02 371 28 and and CC cord-014516-r59usk02 371 29 0.99 0.99 CD cord-014516-r59usk02 371 30 and and CC cord-014516-r59usk02 371 31 1.00 1.00 CD cord-014516-r59usk02 371 32 , , , cord-014516-r59usk02 371 33 in in IN cord-014516-r59usk02 371 34 dogs dog NNS cord-014516-r59usk02 371 35 , , , cord-014516-r59usk02 371 36 respectively respectively RB cord-014516-r59usk02 371 37 . . . cord-014516-r59usk02 372 1 DGlu DGlu NNP cord-014516-r59usk02 372 2 cutoffs cutoff NNS cord-014516-r59usk02 372 3 of of IN cord-014516-r59usk02 372 4 30 30 CD cord-014516-r59usk02 372 5 mg mg NN cord-014516-r59usk02 372 6 / / SYM cord-014516-r59usk02 372 7 dL dL NNP cord-014516-r59usk02 372 8 and and CC cord-014516-r59usk02 372 9 16 16 CD cord-014516-r59usk02 372 10 mg mg NNP cord-014516-r59usk02 372 11 / / SYM cord-014516-r59usk02 372 12 dL dl NN cord-014516-r59usk02 372 13 , , , cord-014516-r59usk02 372 14 in in IN cord-014516-r59usk02 372 15 cats cat NNS cord-014516-r59usk02 372 16 and and CC cord-014516-r59usk02 372 17 dogs dog NNS cord-014516-r59usk02 372 18 , , , cord-014516-r59usk02 372 19 respectively respectively RB cord-014516-r59usk02 372 20 , , , cord-014516-r59usk02 372 21 corresponded correspond VBD cord-014516-r59usk02 372 22 to to IN cord-014516-r59usk02 372 23 sensitivity sensitivity NN cord-014516-r59usk02 372 24 and and CC cord-014516-r59usk02 372 25 specificity specificity NN cord-014516-r59usk02 372 26 of of IN cord-014516-r59usk02 372 27 100 100 CD cord-014516-r59usk02 372 28 % % NN cord-014516-r59usk02 372 29 and and CC cord-014516-r59usk02 372 30 90 90 CD cord-014516-r59usk02 372 31 % % NN cord-014516-r59usk02 372 32 in in IN cord-014516-r59usk02 372 33 cats cat NNS cord-014516-r59usk02 372 34 , , , cord-014516-r59usk02 372 35 respectively respectively RB cord-014516-r59usk02 372 36 , , , cord-014516-r59usk02 372 37 and and CC cord-014516-r59usk02 372 38 100 100 CD cord-014516-r59usk02 372 39 % % NN cord-014516-r59usk02 372 40 in in IN cord-014516-r59usk02 372 41 dogs dog NNS cord-014516-r59usk02 372 42 . . . cord-014516-r59usk02 373 1 DGlu DGlu NNP cord-014516-r59usk02 373 2 and and CC cord-014516-r59usk02 373 3 % % NN cord-014516-r59usk02 373 4 DGlu DGlu NNS cord-014516-r59usk02 373 5 are be VBP cord-014516-r59usk02 373 6 extremely extremely RB cord-014516-r59usk02 373 7 accurate accurate JJ cord-014516-r59usk02 373 8 , , , cord-014516-r59usk02 373 9 readily readily RB cord-014516-r59usk02 373 10 - - HYPH cord-014516-r59usk02 373 11 available available JJ cord-014516-r59usk02 373 12 , , , cord-014516-r59usk02 373 13 simple simple JJ cord-014516-r59usk02 373 14 diagnostic diagnostic JJ cord-014516-r59usk02 373 15 markers marker NNS cord-014516-r59usk02 373 16 of of IN cord-014516-r59usk02 373 17 AATE AATE NNP cord-014516-r59usk02 373 18 in in IN cord-014516-r59usk02 373 19 cats cat NNS cord-014516-r59usk02 373 20 and and CC cord-014516-r59usk02 373 21 dogs dog NNS cord-014516-r59usk02 373 22 . . . cord-014516-r59usk02 374 1 No no DT cord-014516-r59usk02 374 2 conflicts conflict NNS cord-014516-r59usk02 374 3 of of IN cord-014516-r59usk02 374 4 interest interest NN cord-014516-r59usk02 374 5 reported report VBN cord-014516-r59usk02 374 6 . . . cord-014516-r59usk02 375 1 Glycaemia glycaemia NN cord-014516-r59usk02 375 2 determination determination NN cord-014516-r59usk02 375 3 is be VBZ cord-014516-r59usk02 375 4 usually usually RB cord-014516-r59usk02 375 5 included include VBN cord-014516-r59usk02 375 6 in in IN cord-014516-r59usk02 375 7 routine routine JJ cord-014516-r59usk02 375 8 biochemisty biochemisty NN cord-014516-r59usk02 375 9 panels panel NNS cord-014516-r59usk02 375 10 . . . cord-014516-r59usk02 376 1 No no DT cord-014516-r59usk02 376 2 works work NNS cord-014516-r59usk02 376 3 are be VBP cord-014516-r59usk02 376 4 devoted devoted JJ cord-014516-r59usk02 376 5 to to IN cord-014516-r59usk02 376 6 the the DT cord-014516-r59usk02 376 7 evaluation evaluation NN cord-014516-r59usk02 376 8 of of IN cord-014516-r59usk02 376 9 pheripheral pheripheral FW cord-014516-r59usk02 376 10 glycaemia glycaemia NN cord-014516-r59usk02 376 11 in in IN cord-014516-r59usk02 376 12 animals animal NNS cord-014516-r59usk02 376 13 suffering suffer VBG cord-014516-r59usk02 376 14 from from IN cord-014516-r59usk02 376 15 arterial arterial JJ cord-014516-r59usk02 376 16 thrombosis thrombosis NN cord-014516-r59usk02 376 17 . . . cord-014516-r59usk02 377 1 The the DT cord-014516-r59usk02 377 2 aim aim NN cord-014516-r59usk02 377 3 of of IN cord-014516-r59usk02 377 4 this this DT cord-014516-r59usk02 377 5 study study NN cord-014516-r59usk02 377 6 was be VBD cord-014516-r59usk02 377 7 to to TO cord-014516-r59usk02 377 8 document document VB cord-014516-r59usk02 377 9 the the DT cord-014516-r59usk02 377 10 pheripheral pheripheral NNP cord-014516-r59usk02 377 11 glycaemia glycaemia NN cord-014516-r59usk02 377 12 variations variation NNS cord-014516-r59usk02 377 13 in in IN cord-014516-r59usk02 377 14 hypoperfused hypoperfused JJ cord-014516-r59usk02 377 15 limbs limb NNS cord-014516-r59usk02 377 16 of of IN cord-014516-r59usk02 377 17 patients patient NNS cord-014516-r59usk02 377 18 affected affect VBN cord-014516-r59usk02 377 19 by by IN cord-014516-r59usk02 377 20 MRIconfirmed mriconfirmed JJ cord-014516-r59usk02 377 21 arterial arterial JJ cord-014516-r59usk02 377 22 thrombosis thrombosis NN cord-014516-r59usk02 377 23 . . . cord-014516-r59usk02 378 1 Eleven eleven CD cord-014516-r59usk02 378 2 dogs dog NNS cord-014516-r59usk02 378 3 referred refer VBD cord-014516-r59usk02 378 4 for for IN cord-014516-r59usk02 378 5 monoparesis monoparesis NNP cord-014516-r59usk02 378 6 or or CC cord-014516-r59usk02 378 7 paraparesis paraparesis NN cord-014516-r59usk02 378 8 were be VBD cord-014516-r59usk02 378 9 recruited recruit VBN cord-014516-r59usk02 378 10 . . . cord-014516-r59usk02 379 1 Inclusion inclusion NN cord-014516-r59usk02 379 2 criteria criterion NNS cord-014516-r59usk02 379 3 were be VBD cord-014516-r59usk02 379 4 a a DT cord-014516-r59usk02 379 5 clinical clinical JJ cord-014516-r59usk02 379 6 examination examination NN cord-014516-r59usk02 379 7 supportive supportive JJ cord-014516-r59usk02 379 8 of of IN cord-014516-r59usk02 379 9 limb limb NN cord-014516-r59usk02 379 10 hypoperfusion hypoperfusion NN cord-014516-r59usk02 379 11 and and CC cord-014516-r59usk02 379 12 availability availability NN cord-014516-r59usk02 379 13 of of IN cord-014516-r59usk02 379 14 blood blood NN cord-014516-r59usk02 379 15 cell cell NN cord-014516-r59usk02 379 16 count count NN cord-014516-r59usk02 379 17 , , , cord-014516-r59usk02 379 18 biochemical biochemical JJ cord-014516-r59usk02 379 19 profile profile NN cord-014516-r59usk02 379 20 and and CC cord-014516-r59usk02 379 21 urine urine NN cord-014516-r59usk02 379 22 analyses analysis NNS cord-014516-r59usk02 379 23 . . . cord-014516-r59usk02 380 1 Before before IN cord-014516-r59usk02 380 2 MRI MRI NNP cord-014516-r59usk02 380 3 examination examination NN cord-014516-r59usk02 380 4 , , , cord-014516-r59usk02 380 5 peripheral peripheral JJ cord-014516-r59usk02 380 6 glycaemia glycaemia NN cord-014516-r59usk02 380 7 was be VBD cord-014516-r59usk02 380 8 tested test VBN cord-014516-r59usk02 380 9 . . . cord-014516-r59usk02 381 1 Two two CD cord-014516-r59usk02 381 2 blood blood NN cord-014516-r59usk02 381 3 samples sample NNS cord-014516-r59usk02 381 4 were be VBD cord-014516-r59usk02 381 5 obtained obtain VBN cord-014516-r59usk02 381 6 , , , cord-014516-r59usk02 381 7 one one CD cord-014516-r59usk02 381 8 from from IN cord-014516-r59usk02 381 9 the the DT cord-014516-r59usk02 381 10 affected affect VBN cord-014516-r59usk02 381 11 limbs limb NNS cord-014516-r59usk02 381 12 and and CC cord-014516-r59usk02 381 13 one one CD cord-014516-r59usk02 381 14 from from IN cord-014516-r59usk02 381 15 a a DT cord-014516-r59usk02 381 16 healty healty JJ cord-014516-r59usk02 381 17 limb limb NN cord-014516-r59usk02 381 18 . . . cord-014516-r59usk02 382 1 Plasmatic plasmatic JJ cord-014516-r59usk02 382 2 glycaemia glycaemia NN cord-014516-r59usk02 382 3 was be VBD cord-014516-r59usk02 382 4 measured measure VBN cord-014516-r59usk02 382 5 using use VBG cord-014516-r59usk02 382 6 an an DT cord-014516-r59usk02 382 7 automated automate VBN cord-014516-r59usk02 382 8 glucose glucose NN cord-014516-r59usk02 382 9 analyser analyser NN cord-014516-r59usk02 382 10 . . . cord-014516-r59usk02 383 1 All all PDT cord-014516-r59usk02 383 2 the the DT cord-014516-r59usk02 383 3 patients patient NNS cord-014516-r59usk02 383 4 underwent undergo VBD cord-014516-r59usk02 383 5 a a DT cord-014516-r59usk02 383 6 total total JJ cord-014516-r59usk02 383 7 body body NN cord-014516-r59usk02 383 8 MRI MRI NNP cord-014516-r59usk02 383 9 ( ( -LRB- cord-014516-r59usk02 383 10 MRI MRI NNP cord-014516-r59usk02 383 11 Intera Intera NNP cord-014516-r59usk02 383 12 1.5 1.5 CD cord-014516-r59usk02 383 13 T T NNP cord-014516-r59usk02 383 14 , , , cord-014516-r59usk02 383 15 Philips Philips NNP cord-014516-r59usk02 383 16 Medical Medical NNP cord-014516-r59usk02 383 17 Systems Systems NNPS cord-014516-r59usk02 383 18 ) ) -RRB- cord-014516-r59usk02 383 19 that that WDT cord-014516-r59usk02 383 20 provided provide VBD cord-014516-r59usk02 383 21 the the DT cord-014516-r59usk02 383 22 final final JJ cord-014516-r59usk02 383 23 diagnosis diagnosis NN cord-014516-r59usk02 383 24 . . . cord-014516-r59usk02 384 1 The the DT cord-014516-r59usk02 384 2 arterial arterial JJ cord-014516-r59usk02 384 3 thrombosis thrombosis NN cord-014516-r59usk02 384 4 location location NN cord-014516-r59usk02 384 5 was be VBD cord-014516-r59usk02 384 6 documented document VBN cord-014516-r59usk02 384 7 and and CC cord-014516-r59usk02 384 8 the the DT cord-014516-r59usk02 384 9 entity entity NN cord-014516-r59usk02 384 10 was be VBD cord-014516-r59usk02 384 11 scored score VBN cord-014516-r59usk02 384 12 . . . cord-014516-r59usk02 385 1 All all PDT cord-014516-r59usk02 385 2 the the DT cord-014516-r59usk02 385 3 eleven eleven CD cord-014516-r59usk02 385 4 patients patient NNS cord-014516-r59usk02 385 5 were be VBD cord-014516-r59usk02 385 6 diagnosed diagnose VBN cord-014516-r59usk02 385 7 with with IN cord-014516-r59usk02 385 8 a a DT cord-014516-r59usk02 385 9 peripheral peripheral JJ cord-014516-r59usk02 385 10 thrombosis thrombosis NN cord-014516-r59usk02 385 11 involving involve VBG cord-014516-r59usk02 385 12 an an DT cord-014516-r59usk02 385 13 arterial arterial JJ cord-014516-r59usk02 385 14 vessel vessel NN cord-014516-r59usk02 385 15 and and CC cord-014516-r59usk02 385 16 in in IN cord-014516-r59usk02 385 17 some some DT cord-014516-r59usk02 385 18 cases case NNS cord-014516-r59usk02 385 19 the the DT cord-014516-r59usk02 385 20 relative relative JJ cord-014516-r59usk02 385 21 branches branch NNS cord-014516-r59usk02 385 22 . . . cord-014516-r59usk02 386 1 The the DT cord-014516-r59usk02 386 2 thrombus thrombus NN cord-014516-r59usk02 386 3 was be VBD cord-014516-r59usk02 386 4 located locate VBN cord-014516-r59usk02 386 5 : : : cord-014516-r59usk02 386 6 in in IN cord-014516-r59usk02 386 7 the the DT cord-014516-r59usk02 386 8 abdominal abdominal JJ cord-014516-r59usk02 386 9 aorta aorta NN cord-014516-r59usk02 386 10 ( ( -LRB- cord-014516-r59usk02 386 11 7/11 7/11 CD cord-014516-r59usk02 386 12 ) ) -RRB- cord-014516-r59usk02 386 13 , , , cord-014516-r59usk02 386 14 in in IN cord-014516-r59usk02 386 15 the the DT cord-014516-r59usk02 386 16 subclavian subclavian JJ cord-014516-r59usk02 386 17 artery artery NN cord-014516-r59usk02 386 18 ( ( -LRB- cord-014516-r59usk02 386 19 1/11 1/11 CD cord-014516-r59usk02 386 20 ) ) -RRB- cord-014516-r59usk02 386 21 , , , cord-014516-r59usk02 386 22 in in IN cord-014516-r59usk02 386 23 the the DT cord-014516-r59usk02 386 24 axillary axillary JJ cord-014516-r59usk02 386 25 artery artery NN cord-014516-r59usk02 386 26 ( ( -LRB- cord-014516-r59usk02 386 27 1/11 1/11 CD cord-014516-r59usk02 386 28 ) ) -RRB- cord-014516-r59usk02 386 29 , , , cord-014516-r59usk02 386 30 in in IN cord-014516-r59usk02 386 31 the the DT cord-014516-r59usk02 386 32 iliac iliac JJ cord-014516-r59usk02 386 33 arteries artery NNS cord-014516-r59usk02 386 34 ( ( -LRB- cord-014516-r59usk02 386 35 2/11 2/11 CD cord-014516-r59usk02 386 36 ) ) -RRB- cord-014516-r59usk02 386 37 . . . cord-014516-r59usk02 387 1 Of of IN cord-014516-r59usk02 387 2 the the DT cord-014516-r59usk02 387 3 total total JJ cord-014516-r59usk02 387 4 amount amount NN cord-014516-r59usk02 387 5 of of IN cord-014516-r59usk02 387 6 abdominal abdominal JJ cord-014516-r59usk02 387 7 aortic aortic JJ cord-014516-r59usk02 387 8 thrombosis thrombosis NN cord-014516-r59usk02 387 9 , , , cord-014516-r59usk02 387 10 3/7 3/7 CD cord-014516-r59usk02 387 11 involved involve VBN cord-014516-r59usk02 387 12 also also RB cord-014516-r59usk02 387 13 the the DT cord-014516-r59usk02 387 14 internal internal JJ cord-014516-r59usk02 387 15 iliac iliac NNP cord-014516-r59usk02 387 16 arteries artery NNS cord-014516-r59usk02 387 17 , , , cord-014516-r59usk02 387 18 2/7 2/7 CD cord-014516-r59usk02 387 19 the the DT cord-014516-r59usk02 387 20 external external JJ cord-014516-r59usk02 387 21 ones one NNS cord-014516-r59usk02 387 22 and and CC cord-014516-r59usk02 387 23 2/7 2/7 CD cord-014516-r59usk02 388 1 both both DT cord-014516-r59usk02 388 2 internal internal JJ cord-014516-r59usk02 388 3 and and CC cord-014516-r59usk02 388 4 external external JJ cord-014516-r59usk02 388 5 . . . cord-014516-r59usk02 389 1 The the DT cord-014516-r59usk02 389 2 extent extent NN cord-014516-r59usk02 389 3 of of IN cord-014516-r59usk02 389 4 the the DT cord-014516-r59usk02 389 5 thrombosis thrombosis NN cord-014516-r59usk02 389 6 was be VBD cord-014516-r59usk02 389 7 classified classify VBN cord-014516-r59usk02 389 8 as as IN cord-014516-r59usk02 389 9 grade grade NN cord-014516-r59usk02 389 10 1 1 CD cord-014516-r59usk02 389 11 ( ( -LRB- cord-014516-r59usk02 389 12 G1 G1 NNP cord-014516-r59usk02 389 13 ) ) -RRB- cord-014516-r59usk02 389 14 , , , cord-014516-r59usk02 389 15 when when WRB cord-014516-r59usk02 389 16 the the DT cord-014516-r59usk02 389 17 greatest great JJS cord-014516-r59usk02 389 18 portion portion NN cord-014516-r59usk02 389 19 of of IN cord-014516-r59usk02 389 20 the the DT cord-014516-r59usk02 389 21 thrombus thrombus NN cord-014516-r59usk02 389 22 did do VBD cord-014516-r59usk02 389 23 not not RB cord-014516-r59usk02 389 24 reach reach VB cord-014516-r59usk02 389 25 half half NN cord-014516-r59usk02 389 26 of of IN cord-014516-r59usk02 389 27 the the DT cord-014516-r59usk02 389 28 vessel vessel NN cord-014516-r59usk02 389 29 lumen lumen NN cord-014516-r59usk02 389 30 ( ( -LRB- cord-014516-r59usk02 389 31 1/11 1/11 CD cord-014516-r59usk02 389 32 patients patient NNS cord-014516-r59usk02 389 33 ) ) -RRB- cord-014516-r59usk02 389 34 ; ; : cord-014516-r59usk02 389 35 grade grade NN cord-014516-r59usk02 389 36 2 2 CD cord-014516-r59usk02 389 37 ( ( -LRB- cord-014516-r59usk02 389 38 G2 G2 NNP cord-014516-r59usk02 389 39 ) ) -RRB- cord-014516-r59usk02 389 40 , , , cord-014516-r59usk02 389 41 when when WRB cord-014516-r59usk02 389 42 the the DT cord-014516-r59usk02 389 43 greatest great JJS cord-014516-r59usk02 389 44 portion portion NN cord-014516-r59usk02 389 45 of of IN cord-014516-r59usk02 389 46 the the DT cord-014516-r59usk02 389 47 thrombus thrombus NN cord-014516-r59usk02 389 48 was be VBD cord-014516-r59usk02 389 49 between between IN cord-014516-r59usk02 389 50 1/2 1/2 CD cord-014516-r59usk02 389 51 and and CC cord-014516-r59usk02 389 52 2/3 2/3 CD cord-014516-r59usk02 389 53 of of IN cord-014516-r59usk02 389 54 the the DT cord-014516-r59usk02 389 55 vessel vessel NN cord-014516-r59usk02 389 56 lumen lumen NN cord-014516-r59usk02 389 57 ( ( -LRB- cord-014516-r59usk02 389 58 7/11 7/11 CD cord-014516-r59usk02 389 59 ) ) -RRB- cord-014516-r59usk02 389 60 ; ; : cord-014516-r59usk02 389 61 grade grade NN cord-014516-r59usk02 389 62 3 3 CD cord-014516-r59usk02 389 63 ( ( -LRB- cord-014516-r59usk02 389 64 G3 G3 NNP cord-014516-r59usk02 389 65 ) ) -RRB- cord-014516-r59usk02 389 66 , , , cord-014516-r59usk02 389 67 when when WRB cord-014516-r59usk02 389 68 the the DT cord-014516-r59usk02 389 69 thrombus thrombus NN cord-014516-r59usk02 389 70 exceded excede VBD cord-014516-r59usk02 389 71 2/3 2/3 CD cord-014516-r59usk02 389 72 of of IN cord-014516-r59usk02 389 73 the the DT cord-014516-r59usk02 389 74 lumen lumen NN cord-014516-r59usk02 389 75 ( ( -LRB- cord-014516-r59usk02 389 76 3/11 3/11 CD cord-014516-r59usk02 389 77 ) ) -RRB- cord-014516-r59usk02 389 78 . . . cord-014516-r59usk02 390 1 A a DT cord-014516-r59usk02 390 2 substantial substantial JJ cord-014516-r59usk02 390 3 decrease decrease NN cord-014516-r59usk02 390 4 in in IN cord-014516-r59usk02 390 5 pheripheral pheripheral FW cord-014516-r59usk02 390 6 glycaemia glycaemia NN cord-014516-r59usk02 390 7 values value NNS cord-014516-r59usk02 390 8 was be VBD cord-014516-r59usk02 390 9 found find VBN cord-014516-r59usk02 390 10 in in IN cord-014516-r59usk02 390 11 sampling sampling NN cord-014516-r59usk02 390 12 arising arise VBG cord-014516-r59usk02 390 13 from from IN cord-014516-r59usk02 390 14 the the DT cord-014516-r59usk02 390 15 thrombosisaffected thrombosisaffected JJ cord-014516-r59usk02 390 16 limbs limb NNS cord-014516-r59usk02 390 17 . . . cord-014516-r59usk02 391 1 Comparing compare VBG cord-014516-r59usk02 391 2 thrombosis thrombosis NN cord-014516-r59usk02 391 3 - - HYPH cord-014516-r59usk02 391 4 affected affect VBN cord-014516-r59usk02 391 5 limbs limb NNS cord-014516-r59usk02 391 6 values value NNS cord-014516-r59usk02 391 7 with with IN cord-014516-r59usk02 391 8 healthy healthy JJ cord-014516-r59usk02 391 9 limbs limb NNS cord-014516-r59usk02 391 10 measurements measurement NNS cord-014516-r59usk02 391 11 from from IN cord-014516-r59usk02 391 12 the the DT cord-014516-r59usk02 391 13 same same JJ cord-014516-r59usk02 391 14 patient patient NN cord-014516-r59usk02 391 15 , , , cord-014516-r59usk02 391 16 the the DT cord-014516-r59usk02 391 17 reduction reduction NN cord-014516-r59usk02 391 18 was be VBD cord-014516-r59usk02 391 19 found find VBN cord-014516-r59usk02 391 20 from from IN cord-014516-r59usk02 391 21 17.65 17.65 CD cord-014516-r59usk02 391 22 % % NN cord-014516-r59usk02 391 23 to to IN cord-014516-r59usk02 391 24 34.41 34.41 CD cord-014516-r59usk02 391 25 % % NN cord-014516-r59usk02 391 26 . . . cord-014516-r59usk02 392 1 Accounting account VBG cord-014516-r59usk02 392 2 only only RB cord-014516-r59usk02 392 3 the the DT cord-014516-r59usk02 392 4 G3 G3 NNP cord-014516-r59usk02 392 5 scored score VBD cord-014516-r59usk02 392 6 patients patient NNS cord-014516-r59usk02 392 7 , , , cord-014516-r59usk02 392 8 the the DT cord-014516-r59usk02 392 9 percentage percentage NN cord-014516-r59usk02 392 10 of of IN cord-014516-r59usk02 392 11 reduction reduction NN cord-014516-r59usk02 392 12 was be VBD cord-014516-r59usk02 392 13 found find VBN cord-014516-r59usk02 392 14 up up RP cord-014516-r59usk02 392 15 to to IN cord-014516-r59usk02 392 16 the the DT cord-014516-r59usk02 392 17 28.34 28.34 CD cord-014516-r59usk02 392 18 % % NN cord-014516-r59usk02 392 19 suggesting suggest VBG cord-014516-r59usk02 392 20 a a DT cord-014516-r59usk02 392 21 proportional proportional JJ cord-014516-r59usk02 392 22 decrease decrease NN cord-014516-r59usk02 392 23 related relate VBN cord-014516-r59usk02 392 24 to to IN cord-014516-r59usk02 392 25 the the DT cord-014516-r59usk02 392 26 grade grade NN cord-014516-r59usk02 392 27 of of IN cord-014516-r59usk02 392 28 occlusion occlusion NN cord-014516-r59usk02 392 29 . . . cord-014516-r59usk02 393 1 Results result NNS cord-014516-r59usk02 393 2 from from IN cord-014516-r59usk02 393 3 this this DT cord-014516-r59usk02 393 4 study study NN cord-014516-r59usk02 393 5 suggest suggest VBP cord-014516-r59usk02 393 6 that that IN cord-014516-r59usk02 393 7 peripheral peripheral JJ cord-014516-r59usk02 393 8 glycaemia glycaemia NN cord-014516-r59usk02 393 9 values value NNS cord-014516-r59usk02 393 10 are be VBP cord-014516-r59usk02 393 11 affected affect VBN cord-014516-r59usk02 393 12 by by IN cord-014516-r59usk02 393 13 limb limb NN cord-014516-r59usk02 393 14 hypoperfusion hypoperfusion NN cord-014516-r59usk02 393 15 disorders disorder NNS cord-014516-r59usk02 393 16 . . . cord-014516-r59usk02 394 1 If if IN cord-014516-r59usk02 394 2 an an DT cord-014516-r59usk02 394 3 arterial arterial JJ cord-014516-r59usk02 394 4 thrombosis thrombosis NN cord-014516-r59usk02 394 5 is be VBZ cord-014516-r59usk02 394 6 suspected suspect VBN cord-014516-r59usk02 394 7 , , , cord-014516-r59usk02 394 8 samples sample NNS cord-014516-r59usk02 394 9 from from IN cord-014516-r59usk02 394 10 the the DT cord-014516-r59usk02 394 11 affected affected JJ cord-014516-r59usk02 394 12 limbs limb NNS cord-014516-r59usk02 394 13 and and CC cord-014516-r59usk02 394 14 the the DT cord-014516-r59usk02 394 15 healthy healthy JJ cord-014516-r59usk02 394 16 ones one NNS cord-014516-r59usk02 394 17 could could MD cord-014516-r59usk02 394 18 be be VB cord-014516-r59usk02 394 19 used use VBN cord-014516-r59usk02 394 20 to to TO cord-014516-r59usk02 394 21 compare compare VB cord-014516-r59usk02 394 22 glycaemia glycaemia NN cord-014516-r59usk02 394 23 values value NNS cord-014516-r59usk02 394 24 and and CC cord-014516-r59usk02 394 25 to to TO cord-014516-r59usk02 394 26 support support VB cord-014516-r59usk02 394 27 the the DT cord-014516-r59usk02 394 28 early early JJ cord-014516-r59usk02 394 29 stage stage NN cord-014516-r59usk02 394 30 therapy therapy NN cord-014516-r59usk02 394 31 in in IN cord-014516-r59usk02 394 32 anticipation anticipation NN cord-014516-r59usk02 394 33 of of IN cord-014516-r59usk02 394 34 diagnostic diagnostic JJ cord-014516-r59usk02 394 35 imaging imaging NN cord-014516-r59usk02 394 36 . . . cord-014516-r59usk02 395 1 Further further JJ cord-014516-r59usk02 395 2 studies study NNS cord-014516-r59usk02 395 3 are be VBP cord-014516-r59usk02 395 4 needed need VBN cord-014516-r59usk02 395 5 to to TO cord-014516-r59usk02 395 6 confirm confirm VB cord-014516-r59usk02 395 7 the the DT cord-014516-r59usk02 395 8 proportional proportional JJ cord-014516-r59usk02 395 9 relation relation NN cord-014516-r59usk02 395 10 of of IN cord-014516-r59usk02 395 11 the the DT cord-014516-r59usk02 395 12 decrease decrease NN cord-014516-r59usk02 395 13 with with IN cord-014516-r59usk02 395 14 thrombus thrombus NN cord-014516-r59usk02 395 15 entity entity NN cord-014516-r59usk02 395 16 . . . cord-014516-r59usk02 396 1 No no DT cord-014516-r59usk02 396 2 conflicts conflict NNS cord-014516-r59usk02 396 3 of of IN cord-014516-r59usk02 396 4 interest interest NN cord-014516-r59usk02 396 5 reported report VBN cord-014516-r59usk02 396 6 . . . cord-014516-r59usk02 397 1 Canine canine JJ cord-014516-r59usk02 397 2 idiopathic idiopathic JJ cord-014516-r59usk02 397 3 pulmonary pulmonary JJ cord-014516-r59usk02 397 4 fibrosis fibrosis NN cord-014516-r59usk02 397 5 ( ( -LRB- cord-014516-r59usk02 397 6 CIPF CIPF NNP cord-014516-r59usk02 397 7 ) ) -RRB- cord-014516-r59usk02 397 8 is be VBZ cord-014516-r59usk02 397 9 a a DT cord-014516-r59usk02 397 10 progressive progressive JJ cord-014516-r59usk02 397 11 interstitial interstitial JJ cord-014516-r59usk02 397 12 lung lung NN cord-014516-r59usk02 397 13 disease disease NN cord-014516-r59usk02 397 14 mainly mainly RB cord-014516-r59usk02 397 15 affecting affect VBG cord-014516-r59usk02 397 16 West West NNP cord-014516-r59usk02 397 17 Highland Highland NNP cord-014516-r59usk02 397 18 white white JJ cord-014516-r59usk02 397 19 terriers terrier NNS cord-014516-r59usk02 397 20 ( ( -LRB- cord-014516-r59usk02 397 21 WHWT WHWT NNP cord-014516-r59usk02 397 22 ) ) -RRB- cord-014516-r59usk02 397 23 . . . cord-014516-r59usk02 398 1 Pulmonary pulmonary JJ cord-014516-r59usk02 398 2 hypertension hypertension NN cord-014516-r59usk02 398 3 ( ( -LRB- cord-014516-r59usk02 398 4 PH PH NNP cord-014516-r59usk02 398 5 ) ) -RRB- cord-014516-r59usk02 398 6 may may MD cord-014516-r59usk02 398 7 develop develop VB cord-014516-r59usk02 398 8 secondary secondary JJ cord-014516-r59usk02 398 9 to to IN cord-014516-r59usk02 398 10 hypoxic hypoxic JJ cord-014516-r59usk02 398 11 vasoconstriction vasoconstriction NN cord-014516-r59usk02 398 12 and/or and/or CC cord-014516-r59usk02 398 13 pulmonary pulmonary JJ cord-014516-r59usk02 398 14 parenchymal parenchymal NN cord-014516-r59usk02 398 15 infiltration infiltration NN cord-014516-r59usk02 398 16 . . . cord-014516-r59usk02 399 1 In in IN cord-014516-r59usk02 399 2 the the DT cord-014516-r59usk02 399 3 absence absence NN cord-014516-r59usk02 399 4 of of IN cord-014516-r59usk02 399 5 measurable measurable JJ cord-014516-r59usk02 399 6 tricuspid tricuspid JJ cord-014516-r59usk02 399 7 regurgitation regurgitation NN cord-014516-r59usk02 399 8 ( ( -LRB- cord-014516-r59usk02 399 9 TR TR NNP cord-014516-r59usk02 399 10 ) ) -RRB- cord-014516-r59usk02 399 11 , , , cord-014516-r59usk02 399 12 this this DT cord-014516-r59usk02 399 13 co co JJ cord-014516-r59usk02 399 14 - - JJ cord-014516-r59usk02 399 15 morbid morbid JJ cord-014516-r59usk02 399 16 condition condition NN cord-014516-r59usk02 399 17 may may MD cord-014516-r59usk02 399 18 be be VB cord-014516-r59usk02 399 19 difficult difficult JJ cord-014516-r59usk02 399 20 to to TO cord-014516-r59usk02 399 21 diagnose diagnose VB cord-014516-r59usk02 399 22 non non JJ cord-014516-r59usk02 399 23 - - JJ cord-014516-r59usk02 399 24 invasively invasively RB cord-014516-r59usk02 399 25 . . . cord-014516-r59usk02 400 1 The the DT cord-014516-r59usk02 400 2 degree degree NN cord-014516-r59usk02 400 3 of of IN cord-014516-r59usk02 400 4 cardio cardio JJ cord-014516-r59usk02 400 5 - - HYPH cord-014516-r59usk02 400 6 pulmonary pulmonary JJ cord-014516-r59usk02 400 7 impairment impairment NN cord-014516-r59usk02 400 8 in in IN cord-014516-r59usk02 400 9 CIPF CIPF NNP cord-014516-r59usk02 400 10 dogs dog NNS cord-014516-r59usk02 400 11 can can MD cord-014516-r59usk02 400 12 be be VB cord-014516-r59usk02 400 13 evaluated evaluate VBN cord-014516-r59usk02 400 14 through through IN cord-014516-r59usk02 400 15 blood blood NN cord-014516-r59usk02 400 16 gas gas NN cord-014516-r59usk02 400 17 analysis analysis NN cord-014516-r59usk02 400 18 ( ( -LRB- cord-014516-r59usk02 400 19 BGA BGA NNP cord-014516-r59usk02 400 20 ) ) -RRB- cord-014516-r59usk02 400 21 and and CC cord-014516-r59usk02 400 22 6 6 CD cord-014516-r59usk02 400 23 minute minute NN cord-014516-r59usk02 400 24 walking walking NN cord-014516-r59usk02 400 25 test test NN cord-014516-r59usk02 400 26 ( ( -LRB- cord-014516-r59usk02 400 27 6MWT 6MWT NNP cord-014516-r59usk02 400 28 ) ) -RRB- cord-014516-r59usk02 400 29 . . . cord-014516-r59usk02 401 1 A a DT cord-014516-r59usk02 401 2 new new JJ cord-014516-r59usk02 401 3 echocardiographic echocardiographic JJ cord-014516-r59usk02 401 4 index index NN cord-014516-r59usk02 401 5 , , , cord-014516-r59usk02 401 6 the the DT cord-014516-r59usk02 401 7 right right JJ cord-014516-r59usk02 401 8 pulmonary pulmonary JJ cord-014516-r59usk02 401 9 vein vein NN cord-014516-r59usk02 401 10 to to IN cord-014516-r59usk02 401 11 pulmonary pulmonary JJ cord-014516-r59usk02 401 12 artery artery NN cord-014516-r59usk02 401 13 ratio ratio NN cord-014516-r59usk02 401 14 ( ( -LRB- cord-014516-r59usk02 401 15 PV PV NNP cord-014516-r59usk02 401 16 / / SYM cord-014516-r59usk02 401 17 PA PA NNP cord-014516-r59usk02 401 18 ) ) -RRB- cord-014516-r59usk02 401 19 has have VBZ cord-014516-r59usk02 401 20 been be VBN cord-014516-r59usk02 401 21 described describe VBN cord-014516-r59usk02 401 22 for for IN cord-014516-r59usk02 401 23 the the DT cord-014516-r59usk02 401 24 detection detection NN cord-014516-r59usk02 401 25 of of IN cord-014516-r59usk02 401 26 pulmonary pulmonary JJ cord-014516-r59usk02 401 27 venous venous JJ cord-014516-r59usk02 401 28 hypertension hypertension NN cord-014516-r59usk02 401 29 . . . cord-014516-r59usk02 402 1 The the DT cord-014516-r59usk02 402 2 aim aim NN cord-014516-r59usk02 402 3 of of IN cord-014516-r59usk02 402 4 this this DT cord-014516-r59usk02 402 5 study study NN cord-014516-r59usk02 402 6 was be VBD cord-014516-r59usk02 402 7 to to TO cord-014516-r59usk02 402 8 investigate investigate VB cord-014516-r59usk02 402 9 PV PV NNP cord-014516-r59usk02 402 10 / / SYM cord-014516-r59usk02 402 11 PA PA NNP cord-014516-r59usk02 402 12 in in IN cord-014516-r59usk02 402 13 CIPF CIPF NNP cord-014516-r59usk02 402 14 in in IN cord-014516-r59usk02 402 15 order order NN cord-014516-r59usk02 402 16 to to TO cord-014516-r59usk02 402 17 determine determine VB cord-014516-r59usk02 402 18 its -PRON- PRP$ cord-014516-r59usk02 402 19 utility utility NN cord-014516-r59usk02 402 20 in in IN cord-014516-r59usk02 402 21 the the DT cord-014516-r59usk02 402 22 detection detection NN cord-014516-r59usk02 402 23 of of IN cord-014516-r59usk02 402 24 PH PH NNP cord-014516-r59usk02 402 25 and and CC cord-014516-r59usk02 402 26 in in IN cord-014516-r59usk02 402 27 the the DT cord-014516-r59usk02 402 28 assessment assessment NN cord-014516-r59usk02 402 29 of of IN cord-014516-r59usk02 402 30 cardio cardio JJ cord-014516-r59usk02 402 31 - - HYPH cord-014516-r59usk02 402 32 pulmonary pulmonary JJ cord-014516-r59usk02 402 33 disease disease NN cord-014516-r59usk02 402 34 severity severity NN cord-014516-r59usk02 402 35 . . . cord-014516-r59usk02 403 1 This this DT cord-014516-r59usk02 403 2 prospective prospective JJ cord-014516-r59usk02 403 3 clinical clinical JJ cord-014516-r59usk02 403 4 cohort cohort NN cord-014516-r59usk02 403 5 study study NN cord-014516-r59usk02 403 6 included include VBD cord-014516-r59usk02 403 7 10 10 CD cord-014516-r59usk02 403 8 WHWT WHWT NNS cord-014516-r59usk02 403 9 with with IN cord-014516-r59usk02 403 10 CIPF CIPF NNP cord-014516-r59usk02 403 11 ( ( -LRB- cord-014516-r59usk02 403 12 Group Group NNP cord-014516-r59usk02 403 13 A A NNP cord-014516-r59usk02 403 14 ) ) -RRB- cord-014516-r59usk02 403 15 , , , cord-014516-r59usk02 403 16 9 9 CD cord-014516-r59usk02 403 17 healthy healthy JJ cord-014516-r59usk02 403 18 WHWT WHWT NNS cord-014516-r59usk02 403 19 ( ( -LRB- cord-014516-r59usk02 403 20 Group Group NNP cord-014516-r59usk02 403 21 B B NNP cord-014516-r59usk02 403 22 ) ) -RRB- cord-014516-r59usk02 403 23 and and CC cord-014516-r59usk02 403 24 25 25 CD cord-014516-r59usk02 403 25 healthy healthy JJ cord-014516-r59usk02 403 26 dogs dog NNS cord-014516-r59usk02 403 27 from from IN cord-014516-r59usk02 403 28 other other JJ cord-014516-r59usk02 403 29 breeds breed NNS cord-014516-r59usk02 403 30 ( ( -LRB- cord-014516-r59usk02 403 31 Group Group NNP cord-014516-r59usk02 403 32 C C NNP cord-014516-r59usk02 403 33 ) ) -RRB- cord-014516-r59usk02 403 34 . . . cord-014516-r59usk02 404 1 Diameters diameter NNS cord-014516-r59usk02 404 2 of of IN cord-014516-r59usk02 404 3 right right JJ cord-014516-r59usk02 404 4 PV PV NNP cord-014516-r59usk02 404 5 and and CC cord-014516-r59usk02 404 6 PA PA NNP cord-014516-r59usk02 404 7 were be VBD cord-014516-r59usk02 404 8 measured measure VBN cord-014516-r59usk02 404 9 , , , cord-014516-r59usk02 404 10 in in IN cord-014516-r59usk02 404 11 bi bi JJ cord-014516-r59usk02 404 12 - - JJ cord-014516-r59usk02 404 13 dimensional dimensional JJ cord-014516-r59usk02 404 14 ( ( -LRB- cord-014516-r59usk02 404 15 BD BD NNP cord-014516-r59usk02 404 16 ) ) -RRB- cord-014516-r59usk02 404 17 and and CC cord-014516-r59usk02 404 18 M M NNP cord-014516-r59usk02 404 19 - - HYPH cord-014516-r59usk02 404 20 modes modes NNP cord-014516-r59usk02 404 21 ( ( -LRB- cord-014516-r59usk02 404 22 MM MM NNP cord-014516-r59usk02 404 23 ) ) -RRB- cord-014516-r59usk02 404 24 , , , cord-014516-r59usk02 404 25 in in IN cord-014516-r59usk02 404 26 a a DT cord-014516-r59usk02 404 27 parasternal parasternal JJ cord-014516-r59usk02 404 28 right right JJ cord-014516-r59usk02 404 29 long long JJ cord-014516-r59usk02 404 30 axis axis NN cord-014516-r59usk02 404 31 view view NN cord-014516-r59usk02 404 32 , , , cord-014516-r59usk02 404 33 at at IN cord-014516-r59usk02 404 34 the the DT cord-014516-r59usk02 404 35 end end NN cord-014516-r59usk02 404 36 of of IN cord-014516-r59usk02 404 37 the the DT cord-014516-r59usk02 404 38 T T NNP cord-014516-r59usk02 404 39 wave wave NN cord-014516-r59usk02 404 40 . . . cord-014516-r59usk02 405 1 Other other JJ cord-014516-r59usk02 405 2 echocardiographic echocardiographic JJ cord-014516-r59usk02 405 3 parameters parameter NNS cord-014516-r59usk02 405 4 for for IN cord-014516-r59usk02 405 5 evaluation evaluation NN cord-014516-r59usk02 405 6 of of IN cord-014516-r59usk02 405 7 PH PH NNP cord-014516-r59usk02 405 8 were be VBD cord-014516-r59usk02 405 9 also also RB cord-014516-r59usk02 405 10 measured measure VBN cord-014516-r59usk02 405 11 : : : cord-014516-r59usk02 405 12 speed speed NN cord-014516-r59usk02 405 13 of of IN cord-014516-r59usk02 405 14 TR tr NN cord-014516-r59usk02 405 15 , , , cord-014516-r59usk02 405 16 acceleration acceleration NN cord-014516-r59usk02 405 17 time time NN cord-014516-r59usk02 405 18 to to IN cord-014516-r59usk02 405 19 ejection ejection NN cord-014516-r59usk02 405 20 time time NN cord-014516-r59usk02 405 21 ratio ratio NN cord-014516-r59usk02 405 22 of of IN cord-014516-r59usk02 405 23 the the DT cord-014516-r59usk02 405 24 pulmonary pulmonary JJ cord-014516-r59usk02 405 25 flow flow NN cord-014516-r59usk02 406 1 ( ( -LRB- cord-014516-r59usk02 406 2 AT at IN cord-014516-r59usk02 406 3 : : : cord-014516-r59usk02 406 4 ET ET NNP cord-014516-r59usk02 406 5 ) ) -RRB- cord-014516-r59usk02 406 6 and and CC cord-014516-r59usk02 406 7 pulmonary pulmonary JJ cord-014516-r59usk02 406 8 artery artery NN cord-014516-r59usk02 406 9 to to IN cord-014516-r59usk02 406 10 aorta aorta NN cord-014516-r59usk02 406 11 ratio ratio NN cord-014516-r59usk02 406 12 ( ( -LRB- cord-014516-r59usk02 406 13 PA PA NNP cord-014516-r59usk02 406 14 / / SYM cord-014516-r59usk02 406 15 Ao Ao NNP cord-014516-r59usk02 406 16 ) ) -RRB- cord-014516-r59usk02 406 17 . . . cord-014516-r59usk02 407 1 BGA BGA NNP cord-014516-r59usk02 407 2 was be VBD cord-014516-r59usk02 407 3 performed perform VBN cord-014516-r59usk02 407 4 in in IN cord-014516-r59usk02 407 5 14 14 CD cord-014516-r59usk02 407 6 dogs dog NNS cord-014516-r59usk02 407 7 ( ( -LRB- cord-014516-r59usk02 407 8 9 9 CD cord-014516-r59usk02 407 9 , , , cord-014516-r59usk02 407 10 1 1 CD cord-014516-r59usk02 407 11 and and CC cord-014516-r59usk02 407 12 4 4 CD cord-014516-r59usk02 407 13 in in IN cord-014516-r59usk02 407 14 groups group NNS cord-014516-r59usk02 407 15 A A NNP cord-014516-r59usk02 407 16 , , , cord-014516-r59usk02 407 17 B b NN cord-014516-r59usk02 407 18 and and CC cord-014516-r59usk02 407 19 C C NNP cord-014516-r59usk02 407 20 ) ) -RRB- cord-014516-r59usk02 407 21 and and CC cord-014516-r59usk02 407 22 6MWT 6mwt NN cord-014516-r59usk02 407 23 in in IN cord-014516-r59usk02 407 24 17 17 CD cord-014516-r59usk02 407 25 dogs dog NNS cord-014516-r59usk02 407 26 ( ( -LRB- cord-014516-r59usk02 407 27 8 8 CD cord-014516-r59usk02 407 28 , , , cord-014516-r59usk02 407 29 6 6 CD cord-014516-r59usk02 407 30 and and CC cord-014516-r59usk02 407 31 3 3 CD cord-014516-r59usk02 407 32 ) ) -RRB- cord-014516-r59usk02 407 33 . . . cord-014516-r59usk02 408 1 Values value NNS cord-014516-r59usk02 408 2 are be VBP cord-014516-r59usk02 408 3 given give VBN cord-014516-r59usk02 408 4 as as IN cord-014516-r59usk02 408 5 meanAESD meanAESD NNS cord-014516-r59usk02 408 6 . . . cord-014516-r59usk02 409 1 In in IN cord-014516-r59usk02 409 2 BD BD NNP cord-014516-r59usk02 409 3 and and CC cord-014516-r59usk02 409 4 MM MM NNP cord-014516-r59usk02 409 5 mode mode NN cord-014516-r59usk02 409 6 , , , cord-014516-r59usk02 409 7 the the DT cord-014516-r59usk02 409 8 PV PV NNP cord-014516-r59usk02 409 9 / / SYM cord-014516-r59usk02 409 10 PA PA NNP cord-014516-r59usk02 409 11 ratio ratio NN cord-014516-r59usk02 409 12 was be VBD cord-014516-r59usk02 409 13 lower low JJR cord-014516-r59usk02 409 14 in in IN cord-014516-r59usk02 409 15 group group NN cord-014516-r59usk02 409 16 A a NN cord-014516-r59usk02 409 17 ( ( -LRB- cord-014516-r59usk02 409 18 MM MM NNP cord-014516-r59usk02 409 19 : : : cord-014516-r59usk02 409 20 0.62 0.62 CD cord-014516-r59usk02 409 21 AE AE NNP cord-014516-r59usk02 409 22 0.25 0.25 CD cord-014516-r59usk02 409 23 , , , cord-014516-r59usk02 409 24 BD BD NNP cord-014516-r59usk02 409 25 : : : cord-014516-r59usk02 409 26 0.51 0.51 CD cord-014516-r59usk02 409 27 AE AE NNP cord-014516-r59usk02 409 28 0.20 0.20 CD cord-014516-r59usk02 409 29 ) ) -RRB- cord-014516-r59usk02 409 30 compared compare VBN cord-014516-r59usk02 409 31 to to IN cord-014516-r59usk02 409 32 group group NN cord-014516-r59usk02 409 33 B B NNP cord-014516-r59usk02 409 34 ( ( -LRB- cord-014516-r59usk02 409 35 MM MM NNP cord-014516-r59usk02 409 36 : : : cord-014516-r59usk02 409 37 0.98 0.98 CD cord-014516-r59usk02 409 38 AE AE NNP cord-014516-r59usk02 409 39 0.17 0.17 CD cord-014516-r59usk02 409 40 , , , cord-014516-r59usk02 409 41 BD BD NNP cord-014516-r59usk02 409 42 : : : cord-014516-r59usk02 409 43 0.93 0.93 CD cord-014516-r59usk02 409 44 AE AE NNP cord-014516-r59usk02 409 45 0.12 0.12 CD cord-014516-r59usk02 409 46 , , , cord-014516-r59usk02 409 47 P p NN cord-014516-r59usk02 409 48 ≤ ≤ NN cord-014516-r59usk02 409 49 0.01 0.01 CD cord-014516-r59usk02 409 50 ) ) -RRB- cord-014516-r59usk02 409 51 and and CC cord-014516-r59usk02 409 52 group group NN cord-014516-r59usk02 409 53 C C NNP cord-014516-r59usk02 409 54 ( ( -LRB- cord-014516-r59usk02 409 55 MM MM NNP cord-014516-r59usk02 409 56 : : : cord-014516-r59usk02 409 57 1.03 1.03 CD cord-014516-r59usk02 409 58 AE AE NNP cord-014516-r59usk02 409 59 0.13 0.13 CD cord-014516-r59usk02 409 60 , , , cord-014516-r59usk02 409 61 BD BD NNP cord-014516-r59usk02 409 62 : : : cord-014516-r59usk02 409 63 1.00 1.00 CD cord-014516-r59usk02 409 64 AE AE NNP cord-014516-r59usk02 409 65 0.10 0.10 CD cord-014516-r59usk02 409 66 , , , cord-014516-r59usk02 409 67 P p NN cord-014516-r59usk02 409 68 ≤ ≤ NN cord-014516-r59usk02 409 69 0.0001 0.0001 CD cord-014516-r59usk02 409 70 ) ) -RRB- cord-014516-r59usk02 409 71 . . . cord-014516-r59usk02 410 1 The the DT cord-014516-r59usk02 410 2 changes change NNS cord-014516-r59usk02 410 3 in in IN cord-014516-r59usk02 410 4 PV PV NNP cord-014516-r59usk02 410 5 / / SYM cord-014516-r59usk02 410 6 PA PA NNP cord-014516-r59usk02 410 7 were be VBD cord-014516-r59usk02 410 8 both both DT cord-014516-r59usk02 410 9 due due IN cord-014516-r59usk02 410 10 to to IN cord-014516-r59usk02 410 11 an an DT cord-014516-r59usk02 410 12 increase increase NN cord-014516-r59usk02 410 13 of of IN cord-014516-r59usk02 410 14 PA PA NNP cord-014516-r59usk02 410 15 ( ( -LRB- cord-014516-r59usk02 410 16 P p NN cord-014516-r59usk02 410 17 ≤ ≤ NN cord-014516-r59usk02 410 18 0.01 0.01 CD cord-014516-r59usk02 410 19 ) ) -RRB- cord-014516-r59usk02 410 20 and and CC cord-014516-r59usk02 410 21 a a DT cord-014516-r59usk02 410 22 decrease decrease NN cord-014516-r59usk02 410 23 of of IN cord-014516-r59usk02 410 24 PV pv NN cord-014516-r59usk02 410 25 ( ( -LRB- cord-014516-r59usk02 410 26 P p NN cord-014516-r59usk02 410 27 ≤ ≤ NN cord-014516-r59usk02 410 28 0.05 0.05 CD cord-014516-r59usk02 410 29 ) ) -RRB- cord-014516-r59usk02 410 30 . . . cord-014516-r59usk02 411 1 TR TR NNP cord-014516-r59usk02 411 2 was be VBD cord-014516-r59usk02 411 3 found find VBN cord-014516-r59usk02 411 4 in in IN cord-014516-r59usk02 411 5 60 60 CD cord-014516-r59usk02 411 6 % % NN cord-014516-r59usk02 411 7 of of IN cord-014516-r59usk02 411 8 dogs dog NNS cord-014516-r59usk02 411 9 with with IN cord-014516-r59usk02 411 10 CIPF CIPF NNP cord-014516-r59usk02 411 11 ; ; : cord-014516-r59usk02 411 12 mean mean VB cord-014516-r59usk02 411 13 pressure pressure NN cord-014516-r59usk02 411 14 gradient gradient NN cord-014516-r59usk02 411 15 was be VBD cord-014516-r59usk02 412 1 34.03 34.03 CD cord-014516-r59usk02 412 2 AE AE NNP cord-014516-r59usk02 412 3 16.90 16.90 CD cord-014516-r59usk02 412 4 mmHg mmHg NNS cord-014516-r59usk02 412 5 . . . cord-014516-r59usk02 413 1 AT at IN cord-014516-r59usk02 413 2 : : : cord-014516-r59usk02 413 3 ET ET NNP cord-014516-r59usk02 413 4 was be VBD cord-014516-r59usk02 413 5 lower low JJR cord-014516-r59usk02 413 6 in in IN cord-014516-r59usk02 413 7 group group NN cord-014516-r59usk02 413 8 A a NN cord-014516-r59usk02 413 9 ( ( -LRB- cord-014516-r59usk02 413 10 0.42 0.42 CD cord-014516-r59usk02 413 11 AE AE NNP cord-014516-r59usk02 413 12 0.08 0.08 CD cord-014516-r59usk02 413 13 ) ) -RRB- cord-014516-r59usk02 413 14 compared compare VBN cord-014516-r59usk02 413 15 to to IN cord-014516-r59usk02 413 16 group group NN cord-014516-r59usk02 413 17 C C NNP cord-014516-r59usk02 413 18 ( ( -LRB- cord-014516-r59usk02 413 19 0.50 0.50 CD cord-014516-r59usk02 413 20 AE AE NNP cord-014516-r59usk02 413 21 0.04 0.04 CD cord-014516-r59usk02 413 22 , , , cord-014516-r59usk02 413 23 P p NN cord-014516-r59usk02 413 24 = = SYM cord-014516-r59usk02 413 25 0.002 0.002 CD cord-014516-r59usk02 413 26 ) ) -RRB- cord-014516-r59usk02 413 27 and and CC cord-014516-r59usk02 413 28 tended tend VBD cord-014516-r59usk02 413 29 to to TO cord-014516-r59usk02 413 30 be be VB cord-014516-r59usk02 413 31 lower low JJR cord-014516-r59usk02 413 32 compared compare VBN cord-014516-r59usk02 413 33 to to IN cord-014516-r59usk02 413 34 group group NN cord-014516-r59usk02 413 35 B b NN cord-014516-r59usk02 413 36 ( ( -LRB- cord-014516-r59usk02 413 37 0.48 0.48 CD cord-014516-r59usk02 413 38 AE AE NNP cord-014516-r59usk02 413 39 0.07 0.07 CD cord-014516-r59usk02 413 40 , , , cord-014516-r59usk02 413 41 P p NN cord-014516-r59usk02 413 42 = = SYM cord-014516-r59usk02 413 43 0.09 0.09 CD cord-014516-r59usk02 413 44 ) ) -RRB- cord-014516-r59usk02 413 45 . . . cord-014516-r59usk02 414 1 PA PA NNP cord-014516-r59usk02 414 2 / / SYM cord-014516-r59usk02 414 3 Ao Ao NNP cord-014516-r59usk02 414 4 was be VBD cord-014516-r59usk02 414 5 not not RB cord-014516-r59usk02 414 6 statistically statistically RB cord-014516-r59usk02 414 7 different different JJ cord-014516-r59usk02 414 8 between between IN cord-014516-r59usk02 414 9 groups group NNS cord-014516-r59usk02 414 10 . . . cord-014516-r59usk02 415 1 PV PV NNP cord-014516-r59usk02 415 2 / / SYM cord-014516-r59usk02 415 3 PA PA NNP cord-014516-r59usk02 415 4 was be VBD cord-014516-r59usk02 415 5 correlated correlate VBN cord-014516-r59usk02 415 6 with with IN cord-014516-r59usk02 415 7 arterial arterial JJ cord-014516-r59usk02 415 8 pO po NN cord-014516-r59usk02 415 9 2 2 CD cord-014516-r59usk02 415 10 values value NNS cord-014516-r59usk02 415 11 ( ( -LRB- cord-014516-r59usk02 415 12 B b NN cord-014516-r59usk02 415 13 mode mode NN cord-014516-r59usk02 415 14 : : : cord-014516-r59usk02 415 15 r r NN cord-014516-r59usk02 415 16 = = NN cord-014516-r59usk02 415 17 0.870 0.870 CD cord-014516-r59usk02 415 18 , , , cord-014516-r59usk02 415 19 P p NN cord-014516-r59usk02 415 20 = = SYM cord-014516-r59usk02 415 21 0.0001 0.0001 CD cord-014516-r59usk02 415 22 ) ) -RRB- cord-014516-r59usk02 415 23 and and CC cord-014516-r59usk02 415 24 results result NNS cord-014516-r59usk02 415 25 of of IN cord-014516-r59usk02 415 26 the the DT cord-014516-r59usk02 415 27 6MWT 6mwt NN cord-014516-r59usk02 415 28 ( ( -LRB- cord-014516-r59usk02 415 29 B b NN cord-014516-r59usk02 415 30 mode mode NN cord-014516-r59usk02 415 31 : : : cord-014516-r59usk02 415 32 r r NN cord-014516-r59usk02 415 33 = = SYM cord-014516-r59usk02 415 34 0.791 0.791 CD cord-014516-r59usk02 415 35 , , , cord-014516-r59usk02 415 36 P p NN cord-014516-r59usk02 415 37 = = SYM cord-014516-r59usk02 415 38 0.0003 0.0003 CD cord-014516-r59usk02 415 39 ) ) -RRB- cord-014516-r59usk02 415 40 . . . cord-014516-r59usk02 416 1 PV PV NNP cord-014516-r59usk02 416 2 / / SYM cord-014516-r59usk02 416 3 PA PA NNP cord-014516-r59usk02 416 4 was be VBD cord-014516-r59usk02 416 5 also also RB cord-014516-r59usk02 416 6 correlated correlate VBN cord-014516-r59usk02 416 7 with with IN cord-014516-r59usk02 416 8 AT at NN cord-014516-r59usk02 416 9 : : : cord-014516-r59usk02 416 10 ET ET NNP cord-014516-r59usk02 416 11 and and CC cord-014516-r59usk02 416 12 the the DT cord-014516-r59usk02 416 13 speed speed NN cord-014516-r59usk02 416 14 of of IN cord-014516-r59usk02 416 15 TR tr NN cord-014516-r59usk02 416 16 , , , cord-014516-r59usk02 416 17 but but CC cord-014516-r59usk02 416 18 not not RB cord-014516-r59usk02 416 19 with with IN cord-014516-r59usk02 416 20 PA PA NNP cord-014516-r59usk02 416 21 / / SYM cord-014516-r59usk02 416 22 Ao Ao NNP cord-014516-r59usk02 416 23 . . . cord-014516-r59usk02 417 1 In in IN cord-014516-r59usk02 417 2 conclusion conclusion NN cord-014516-r59usk02 417 3 , , , cord-014516-r59usk02 417 4 in in IN cord-014516-r59usk02 417 5 WHWT whwt NN cord-014516-r59usk02 417 6 affected affect VBN cord-014516-r59usk02 417 7 by by IN cord-014516-r59usk02 417 8 CIPF CIPF NNP cord-014516-r59usk02 417 9 , , , cord-014516-r59usk02 417 10 PV PV NNP cord-014516-r59usk02 417 11 / / SYM cord-014516-r59usk02 417 12 PA PA NNP cord-014516-r59usk02 417 13 is be VBZ cord-014516-r59usk02 417 14 a a DT cord-014516-r59usk02 417 15 useful useful JJ cord-014516-r59usk02 417 16 indicator indicator NN cord-014516-r59usk02 417 17 of of IN cord-014516-r59usk02 417 18 PH PH NNP cord-014516-r59usk02 417 19 and and CC cord-014516-r59usk02 417 20 could could MD cord-014516-r59usk02 417 21 serve serve VB cord-014516-r59usk02 417 22 in in IN cord-014516-r59usk02 417 23 the the DT cord-014516-r59usk02 417 24 assessment assessment NN cord-014516-r59usk02 417 25 of of IN cord-014516-r59usk02 417 26 disease disease NN cord-014516-r59usk02 417 27 severity severity NN cord-014516-r59usk02 417 28 . . . cord-014516-r59usk02 418 1 No no DT cord-014516-r59usk02 418 2 conflicts conflict NNS cord-014516-r59usk02 418 3 of of IN cord-014516-r59usk02 418 4 interest interest NN cord-014516-r59usk02 418 5 reported report VBN cord-014516-r59usk02 418 6 . . . cord-014516-r59usk02 419 1 Ventricular ventricular JJ cord-014516-r59usk02 419 2 septal septal JJ cord-014516-r59usk02 419 3 defect defect NN cord-014516-r59usk02 419 4 ( ( -LRB- cord-014516-r59usk02 419 5 VSD VSD NNP cord-014516-r59usk02 419 6 ) ) -RRB- cord-014516-r59usk02 419 7 is be VBZ cord-014516-r59usk02 419 8 the the DT cord-014516-r59usk02 419 9 fourth fourth JJ cord-014516-r59usk02 419 10 most most RBS cord-014516-r59usk02 419 11 common common JJ cord-014516-r59usk02 419 12 congenital congenital JJ cord-014516-r59usk02 419 13 cardiac cardiac JJ cord-014516-r59usk02 419 14 defect defect NN cord-014516-r59usk02 419 15 in in IN cord-014516-r59usk02 419 16 dogs dog NNS cord-014516-r59usk02 419 17 and and CC cord-014516-r59usk02 419 18 the the DT cord-014516-r59usk02 419 19 most most RBS cord-014516-r59usk02 419 20 common common JJ cord-014516-r59usk02 419 21 in in IN cord-014516-r59usk02 419 22 cats cat NNS cord-014516-r59usk02 419 23 . . . cord-014516-r59usk02 420 1 The the DT cord-014516-r59usk02 420 2 aim aim NN cord-014516-r59usk02 420 3 of of IN cord-014516-r59usk02 420 4 this this DT cord-014516-r59usk02 420 5 study study NN cord-014516-r59usk02 420 6 was be VBD cord-014516-r59usk02 420 7 to to TO cord-014516-r59usk02 420 8 evaluate evaluate VB cord-014516-r59usk02 420 9 the the DT cord-014516-r59usk02 420 10 long long JJ cord-014516-r59usk02 420 11 - - HYPH cord-014516-r59usk02 420 12 term term NN cord-014516-r59usk02 420 13 outcome outcome NN cord-014516-r59usk02 420 14 in in IN cord-014516-r59usk02 420 15 VSD VSD NNP cord-014516-r59usk02 420 16 patients patient NNS cord-014516-r59usk02 420 17 . . . cord-014516-r59usk02 421 1 Case case NN cord-014516-r59usk02 421 2 records record NNS cord-014516-r59usk02 421 3 of of IN cord-014516-r59usk02 421 4 95 95 CD cord-014516-r59usk02 421 5 animals animal NNS cord-014516-r59usk02 421 6 were be VBD cord-014516-r59usk02 421 7 reviewed review VBN cord-014516-r59usk02 421 8 , , , cord-014516-r59usk02 421 9 46 46 CD cord-014516-r59usk02 421 10 of of IN cord-014516-r59usk02 421 11 these these DT cord-014516-r59usk02 421 12 re re NNS cord-014516-r59usk02 421 13 - - JJ cord-014516-r59usk02 421 14 evaluated evaluate VBN cord-014516-r59usk02 421 15 echocardiographically echocardiographically RB cord-014516-r59usk02 421 16 and and CC cord-014516-r59usk02 421 17 49 49 CD cord-014516-r59usk02 421 18 followed follow VBD cord-014516-r59usk02 421 19 up up RP cord-014516-r59usk02 421 20 by by IN cord-014516-r59usk02 421 21 phone phone NN cord-014516-r59usk02 421 22 interview interview NN cord-014516-r59usk02 421 23 only only RB cord-014516-r59usk02 421 24 . . . cord-014516-r59usk02 422 1 Out out IN cord-014516-r59usk02 422 2 of of IN cord-014516-r59usk02 422 3 53 53 CD cord-014516-r59usk02 422 4 dogs dog NNS cord-014516-r59usk02 422 5 Pug Pug NNP cord-014516-r59usk02 422 6 was be VBD cord-014516-r59usk02 422 7 the the DT cord-014516-r59usk02 422 8 most most RBS cord-014516-r59usk02 422 9 common common JJ cord-014516-r59usk02 422 10 breed breed NN cord-014516-r59usk02 422 11 ( ( -LRB- cord-014516-r59usk02 422 12 11 11 CD cord-014516-r59usk02 422 13 % % NN cord-014516-r59usk02 422 14 ) ) -RRB- cord-014516-r59usk02 422 15 followed follow VBN cord-014516-r59usk02 422 16 by by IN cord-014516-r59usk02 422 17 Border Border NNP cord-014516-r59usk02 422 18 Terrier Terrier NNP cord-014516-r59usk02 422 19 ( ( -LRB- cord-014516-r59usk02 422 20 8 8 CD cord-014516-r59usk02 422 21 % % NN cord-014516-r59usk02 422 22 ) ) -RRB- cord-014516-r59usk02 422 23 . . . cord-014516-r59usk02 423 1 Out out IN cord-014516-r59usk02 423 2 of of IN cord-014516-r59usk02 423 3 42 42 CD cord-014516-r59usk02 423 4 cats cat NNS cord-014516-r59usk02 423 5 Domestic domestic JJ cord-014516-r59usk02 423 6 Short Short NNP cord-014516-r59usk02 423 7 Hair Hair NNP cord-014516-r59usk02 423 8 was be VBD cord-014516-r59usk02 423 9 most most RBS cord-014516-r59usk02 423 10 common common JJ cord-014516-r59usk02 423 11 ( ( -LRB- cord-014516-r59usk02 423 12 55 55 CD cord-014516-r59usk02 423 13 % % NN cord-014516-r59usk02 423 14 ) ) -RRB- cord-014516-r59usk02 423 15 followed follow VBN cord-014516-r59usk02 423 16 by by IN cord-014516-r59usk02 423 17 Main Main NNP cord-014516-r59usk02 423 18 Coon Coon NNP cord-014516-r59usk02 423 19 ( ( -LRB- cord-014516-r59usk02 423 20 19 19 CD cord-014516-r59usk02 423 21 % % NN cord-014516-r59usk02 423 22 ) ) -RRB- cord-014516-r59usk02 423 23 . . . cord-014516-r59usk02 424 1 Isolated isolated JJ cord-014516-r59usk02 424 2 VSDs vsd NNS cord-014516-r59usk02 424 3 were be VBD cord-014516-r59usk02 424 4 present present JJ cord-014516-r59usk02 424 5 in in IN cord-014516-r59usk02 424 6 29 29 CD cord-014516-r59usk02 424 7 dogs dog NNS cord-014516-r59usk02 424 8 and and CC cord-014516-r59usk02 424 9 26 26 CD cord-014516-r59usk02 424 10 cats cat NNS cord-014516-r59usk02 424 11 . . . cord-014516-r59usk02 425 1 Complex complex JJ cord-014516-r59usk02 425 2 defects defect NNS cord-014516-r59usk02 425 3 ( ( -LRB- cord-014516-r59usk02 425 4 CDs cd NNS cord-014516-r59usk02 425 5 ) ) -RRB- cord-014516-r59usk02 425 6 were be VBD cord-014516-r59usk02 425 7 present present JJ cord-014516-r59usk02 425 8 in in IN cord-014516-r59usk02 425 9 40 40 CD cord-014516-r59usk02 425 10 cases case NNS cord-014516-r59usk02 425 11 , , , cord-014516-r59usk02 425 12 most most RBS cord-014516-r59usk02 425 13 frequent frequent JJ cord-014516-r59usk02 425 14 anomalies anomaly NNS cord-014516-r59usk02 425 15 being be VBG cord-014516-r59usk02 425 16 sub sub JJ cord-014516-r59usk02 425 17 - - JJ cord-014516-r59usk02 425 18 aortic aortic JJ cord-014516-r59usk02 425 19 stenosis stenosis NN cord-014516-r59usk02 425 20 ( ( -LRB- cord-014516-r59usk02 425 21 9 9 CD cord-014516-r59usk02 425 22 dogs dog NNS cord-014516-r59usk02 425 23 , , , cord-014516-r59usk02 425 24 1 1 CD cord-014516-r59usk02 425 25 cat cat NN cord-014516-r59usk02 425 26 ) ) -RRB- cord-014516-r59usk02 425 27 , , , cord-014516-r59usk02 425 28 pulmonic pulmonic JJ cord-014516-r59usk02 425 29 stenosis stenosis NN cord-014516-r59usk02 425 30 ( ( -LRB- cord-014516-r59usk02 425 31 5 5 CD cord-014516-r59usk02 425 32 dogs dog NNS cord-014516-r59usk02 425 33 , , , cord-014516-r59usk02 425 34 3 3 CD cord-014516-r59usk02 425 35 cats cat NNS cord-014516-r59usk02 425 36 ) ) -RRB- cord-014516-r59usk02 425 37 , , , cord-014516-r59usk02 425 38 Tetralogy Tetralogy NNP cord-014516-r59usk02 425 39 of of IN cord-014516-r59usk02 425 40 Fallot Fallot NNP cord-014516-r59usk02 425 41 ( ( -LRB- cord-014516-r59usk02 425 42 3 3 CD cord-014516-r59usk02 425 43 dogs dog NNS cord-014516-r59usk02 425 44 , , , cord-014516-r59usk02 425 45 2 2 CD cord-014516-r59usk02 425 46 cats cat NNS cord-014516-r59usk02 425 47 ) ) -RRB- cord-014516-r59usk02 425 48 , , , cord-014516-r59usk02 425 49 cushion cushion NN cord-014516-r59usk02 425 50 defects defect NNS cord-014516-r59usk02 425 51 ( ( -LRB- cord-014516-r59usk02 425 52 5 5 CD cord-014516-r59usk02 425 53 cats cat NNS cord-014516-r59usk02 425 54 ) ) -RRB- cord-014516-r59usk02 425 55 and and CC cord-014516-r59usk02 425 56 double double JJ cord-014516-r59usk02 425 57 - - HYPH cord-014516-r59usk02 425 58 chambered chambered JJ cord-014516-r59usk02 425 59 right right JJ cord-014516-r59usk02 425 60 ventricle ventricle NN cord-014516-r59usk02 425 61 ( ( -LRB- cord-014516-r59usk02 425 62 DCRV DCRV NNP cord-014516-r59usk02 425 63 ) ) -RRB- cord-014516-r59usk02 425 64 ( ( -LRB- cord-014516-r59usk02 425 65 5 5 CD cord-014516-r59usk02 425 66 dogs dog NNS cord-014516-r59usk02 425 67 , , , cord-014516-r59usk02 425 68 4 4 CD cord-014516-r59usk02 425 69 cats cat NNS cord-014516-r59usk02 425 70 ; ; : cord-014516-r59usk02 425 71 in in IN cord-014516-r59usk02 425 72 2/5 2/5 CD cord-014516-r59usk02 425 73 dogs dog NNS cord-014516-r59usk02 425 74 not not RB cord-014516-r59usk02 425 75 present present JJ cord-014516-r59usk02 425 76 initially initially RB cord-014516-r59usk02 425 77 supporting support VBG cord-014516-r59usk02 425 78 the the DT cord-014516-r59usk02 425 79 cause cause NN cord-014516-r59usk02 425 80 - - HYPH cord-014516-r59usk02 425 81 and and CC cord-014516-r59usk02 425 82 - - HYPH cord-014516-r59usk02 425 83 effect effect NN cord-014516-r59usk02 425 84 theory theory NN cord-014516-r59usk02 425 85 ) ) -RRB- cord-014516-r59usk02 425 86 . . . cord-014516-r59usk02 426 1 Eisenmenger Eisenmenger NNP cord-014516-r59usk02 426 2 was be VBD cord-014516-r59usk02 426 3 observed observe VBN cord-014516-r59usk02 426 4 in in IN cord-014516-r59usk02 426 5 1 1 CD cord-014516-r59usk02 426 6 dog dog NN cord-014516-r59usk02 426 7 and and CC cord-014516-r59usk02 426 8 2 2 CD cord-014516-r59usk02 426 9 cats cat NNS cord-014516-r59usk02 426 10 . . . cord-014516-r59usk02 427 1 Aortic aortic JJ cord-014516-r59usk02 427 2 insufficiency insufficiency NN cord-014516-r59usk02 427 3 , , , cord-014516-r59usk02 427 4 not not RB cord-014516-r59usk02 427 5 considered consider VBN cord-014516-r59usk02 427 6 a a DT cord-014516-r59usk02 427 7 CD cd NN cord-014516-r59usk02 427 8 , , , cord-014516-r59usk02 427 9 was be VBD cord-014516-r59usk02 427 10 noted note VBN cord-014516-r59usk02 427 11 in in IN cord-014516-r59usk02 427 12 10 10 CD cord-014516-r59usk02 427 13 dogs dog NNS cord-014516-r59usk02 427 14 . . . cord-014516-r59usk02 428 1 In in IN cord-014516-r59usk02 428 2 3 3 CD cord-014516-r59usk02 428 3 dogs dog NNS cord-014516-r59usk02 428 4 and and CC cord-014516-r59usk02 428 5 6 6 CD cord-014516-r59usk02 428 6 cats cat NNS cord-014516-r59usk02 428 7 ( ( -LRB- cord-014516-r59usk02 428 8 15 15 CD cord-014516-r59usk02 428 9 % % NN cord-014516-r59usk02 428 10 of of IN cord-014516-r59usk02 428 11 isolated isolated JJ cord-014516-r59usk02 428 12 VSDs vsd NNS cord-014516-r59usk02 428 13 and and CC cord-014516-r59usk02 428 14 1 1 CD cord-014516-r59usk02 428 15 cat cat NN cord-014516-r59usk02 428 16 with with IN cord-014516-r59usk02 428 17 a a DT cord-014516-r59usk02 428 18 DCRV DCRV NNP cord-014516-r59usk02 428 19 ) ) -RRB- cord-014516-r59usk02 429 1 the the DT cord-014516-r59usk02 429 2 defect defect NN cord-014516-r59usk02 429 3 closed close VBD cord-014516-r59usk02 429 4 spontaneously spontaneously RB cord-014516-r59usk02 429 5 . . . cord-014516-r59usk02 430 1 Nine nine CD cord-014516-r59usk02 430 2 dogs dog NNS cord-014516-r59usk02 430 3 and and CC cord-014516-r59usk02 430 4 9 9 CD cord-014516-r59usk02 430 5 cats cat NNS cord-014516-r59usk02 430 6 ( ( -LRB- cord-014516-r59usk02 430 7 22 22 CD cord-014516-r59usk02 430 8 % % NN cord-014516-r59usk02 430 9 ) ) -RRB- cord-014516-r59usk02 430 10 died die VBD cord-014516-r59usk02 430 11 of of IN cord-014516-r59usk02 430 12 non non JJ cord-014516-r59usk02 430 13 - - JJ cord-014516-r59usk02 430 14 cardiac cardiac JJ cord-014516-r59usk02 430 15 causes cause NNS cord-014516-r59usk02 430 16 with with IN cord-014516-r59usk02 430 17 an an DT cord-014516-r59usk02 430 18 age age NN cord-014516-r59usk02 430 19 at at IN cord-014516-r59usk02 430 20 death death NN cord-014516-r59usk02 430 21 of of IN cord-014516-r59usk02 430 22 5 5 CD cord-014516-r59usk02 430 23 to to IN cord-014516-r59usk02 430 24 204 204 CD cord-014516-r59usk02 431 1 ( ( -LRB- cord-014516-r59usk02 431 2 mean mean VB cord-014516-r59usk02 431 3 63.8 63.8 CD cord-014516-r59usk02 431 4 ) ) -RRB- cord-014516-r59usk02 431 5 months month NNS cord-014516-r59usk02 431 6 ; ; : cord-014516-r59usk02 431 7 7 7 CD cord-014516-r59usk02 431 8 dogs dog NNS cord-014516-r59usk02 431 9 and and CC cord-014516-r59usk02 431 10 8 8 CD cord-014516-r59usk02 431 11 cats cat NNS cord-014516-r59usk02 431 12 died die VBD cord-014516-r59usk02 431 13 due due JJ cord-014516-r59usk02 431 14 to to IN cord-014516-r59usk02 431 15 cardiac cardiac JJ cord-014516-r59usk02 431 16 causes cause NNS cord-014516-r59usk02 431 17 with with IN cord-014516-r59usk02 431 18 an an DT cord-014516-r59usk02 431 19 age age NN cord-014516-r59usk02 431 20 at at IN cord-014516-r59usk02 431 21 death death NN cord-014516-r59usk02 431 22 of of IN cord-014516-r59usk02 431 23 0.25 0.25 CD cord-014516-r59usk02 431 24 to to IN cord-014516-r59usk02 431 25 204 204 CD cord-014516-r59usk02 432 1 ( ( -LRB- cord-014516-r59usk02 432 2 mean mean VB cord-014516-r59usk02 432 3 37.5 37.5 CD cord-014516-r59usk02 432 4 ) ) -RRB- cord-014516-r59usk02 432 5 months month NNS cord-014516-r59usk02 432 6 . . . cord-014516-r59usk02 433 1 Cardiac cardiac JJ cord-014516-r59usk02 433 2 deaths death NNS cord-014516-r59usk02 433 3 were be VBD cord-014516-r59usk02 433 4 sudden sudden JJ cord-014516-r59usk02 433 5 ( ( -LRB- cord-014516-r59usk02 433 6 2 2 CD cord-014516-r59usk02 433 7 dogs dog NNS cord-014516-r59usk02 433 8 with with IN cord-014516-r59usk02 433 9 CDs cd NNS cord-014516-r59usk02 433 10 ) ) -RRB- cord-014516-r59usk02 433 11 or or CC cord-014516-r59usk02 433 12 euthanasia euthanasia NN cord-014516-r59usk02 433 13 for for IN cord-014516-r59usk02 433 14 left left JJ cord-014516-r59usk02 433 15 sided sided JJ cord-014516-r59usk02 433 16 congestive congestive JJ cord-014516-r59usk02 433 17 heart heart NN cord-014516-r59usk02 433 18 ( ( -LRB- cord-014516-r59usk02 433 19 CHF CHF NNP cord-014516-r59usk02 433 20 ) ) -RRB- cord-014516-r59usk02 433 21 failure failure NN cord-014516-r59usk02 433 22 associated associate VBN cord-014516-r59usk02 433 23 with with IN cord-014516-r59usk02 433 24 CDs cd NNS cord-014516-r59usk02 433 25 ( ( -LRB- cord-014516-r59usk02 433 26 3 3 CD cord-014516-r59usk02 433 27 dogs dog NNS cord-014516-r59usk02 433 28 , , , cord-014516-r59usk02 433 29 1 1 CD cord-014516-r59usk02 433 30 cat cat NN cord-014516-r59usk02 433 31 ) ) -RRB- cord-014516-r59usk02 433 32 ; ; : cord-014516-r59usk02 433 33 right right JJ cord-014516-r59usk02 433 34 sided sided JJ cord-014516-r59usk02 433 35 CHF CHF NNP cord-014516-r59usk02 433 36 associated associate VBN cord-014516-r59usk02 433 37 with with IN cord-014516-r59usk02 433 38 CDs cd NNS cord-014516-r59usk02 433 39 ( ( -LRB- cord-014516-r59usk02 433 40 2 2 CD cord-014516-r59usk02 433 41 cats cat NNS cord-014516-r59usk02 433 42 ) ) -RRB- cord-014516-r59usk02 433 43 ; ; , cord-014516-r59usk02 433 44 biventricular biventricular JJ cord-014516-r59usk02 433 45 failure failure NN cord-014516-r59usk02 433 46 ( ( -LRB- cord-014516-r59usk02 433 47 1 1 CD cord-014516-r59usk02 433 48 cat cat NN cord-014516-r59usk02 433 49 with with IN cord-014516-r59usk02 433 50 CD CD NNP cord-014516-r59usk02 433 51 ) ) -RRB- cord-014516-r59usk02 433 52 ; ; : cord-014516-r59usk02 433 53 weakness weakness NN cord-014516-r59usk02 433 54 ( ( -LRB- cord-014516-r59usk02 433 55 Eisenmenger Eisenmenger NNP cord-014516-r59usk02 433 56 , , , cord-014516-r59usk02 433 57 1 1 CD cord-014516-r59usk02 433 58 dog dog NN cord-014516-r59usk02 433 59 and and CC cord-014516-r59usk02 433 60 1 1 CD cord-014516-r59usk02 433 61 cat cat NN cord-014516-r59usk02 433 62 ; ; : cord-014516-r59usk02 433 63 Fallot Fallot NNP cord-014516-r59usk02 433 64 1 1 CD cord-014516-r59usk02 433 65 dog dog NN cord-014516-r59usk02 433 66 ; ; : cord-014516-r59usk02 433 67 CD CD NNP cord-014516-r59usk02 433 68 1 1 CD cord-014516-r59usk02 433 69 cat cat NN cord-014516-r59usk02 433 70 ) ) -RRB- cord-014516-r59usk02 433 71 . . . cord-014516-r59usk02 434 1 Two two CD cord-014516-r59usk02 434 2 cats cat NNS cord-014516-r59usk02 434 3 developed develop VBD cord-014516-r59usk02 434 4 CHF CHF NNP cord-014516-r59usk02 434 5 due due JJ cord-014516-r59usk02 434 6 to to IN cord-014516-r59usk02 434 7 unrelated unrelated JJ cord-014516-r59usk02 434 8 HCM HCM NNP cord-014516-r59usk02 434 9 . . . cord-014516-r59usk02 435 1 Only only RB cord-014516-r59usk02 435 2 one one CD cord-014516-r59usk02 435 3 dog dog NN cord-014516-r59usk02 435 4 with with IN cord-014516-r59usk02 435 5 an an DT cord-014516-r59usk02 435 6 isolated isolated JJ cord-014516-r59usk02 435 7 VSD vsd NN cord-014516-r59usk02 435 8 was be VBD cord-014516-r59usk02 435 9 euthanized euthanize VBN cord-014516-r59usk02 435 10 for for IN cord-014516-r59usk02 435 11 CHF CHF NNP cord-014516-r59usk02 435 12 . . . cord-014516-r59usk02 436 1 These these DT cord-014516-r59usk02 436 2 results result NNS cord-014516-r59usk02 436 3 indicate indicate VBP cord-014516-r59usk02 436 4 that that IN cord-014516-r59usk02 436 5 spontaneous spontaneous JJ cord-014516-r59usk02 436 6 VSD vsd NN cord-014516-r59usk02 436 7 closure closure NN cord-014516-r59usk02 436 8 occurs occur VBZ cord-014516-r59usk02 436 9 more more RBR cord-014516-r59usk02 436 10 often often RB cord-014516-r59usk02 436 11 than than IN cord-014516-r59usk02 436 12 previously previously RB cord-014516-r59usk02 436 13 thought think VBN cord-014516-r59usk02 436 14 , , , cord-014516-r59usk02 436 15 most most JJS cord-014516-r59usk02 436 16 patients patient NNS cord-014516-r59usk02 436 17 with with IN cord-014516-r59usk02 436 18 isolated isolated JJ cord-014516-r59usk02 436 19 restrictive restrictive JJ cord-014516-r59usk02 436 20 VSDs vsd NNS cord-014516-r59usk02 436 21 live live VBP cord-014516-r59usk02 436 22 a a DT cord-014516-r59usk02 436 23 normal normal JJ cord-014516-r59usk02 436 24 life life NN cord-014516-r59usk02 436 25 span span NN cord-014516-r59usk02 436 26 without without IN cord-014516-r59usk02 436 27 surgical surgical JJ cord-014516-r59usk02 436 28 intervention intervention NN cord-014516-r59usk02 436 29 , , , cord-014516-r59usk02 436 30 but but CC cord-014516-r59usk02 436 31 non non JJ cord-014516-r59usk02 436 32 - - JJ cord-014516-r59usk02 436 33 restrictive restrictive JJ cord-014516-r59usk02 436 34 VSDs vsd NNS cord-014516-r59usk02 436 35 or or CC cord-014516-r59usk02 436 36 complex complex JJ cord-014516-r59usk02 436 37 defects defect NNS cord-014516-r59usk02 436 38 can can MD cord-014516-r59usk02 436 39 be be VB cord-014516-r59usk02 436 40 associated associate VBN cord-014516-r59usk02 436 41 with with IN cord-014516-r59usk02 436 42 significant significant JJ cord-014516-r59usk02 436 43 morbidity morbidity NN cord-014516-r59usk02 436 44 and and CC cord-014516-r59usk02 436 45 mortality mortality NN cord-014516-r59usk02 436 46 . . . cord-014516-r59usk02 437 1 Echocardiography echocardiography NN cord-014516-r59usk02 437 2 early early RB cord-014516-r59usk02 437 3 in in IN cord-014516-r59usk02 437 4 life life NN cord-014516-r59usk02 437 5 is be VBZ cord-014516-r59usk02 437 6 crucial crucial JJ cord-014516-r59usk02 437 7 to to TO cord-014516-r59usk02 437 8 identify identify VB cord-014516-r59usk02 437 9 the the DT cord-014516-r59usk02 437 10 anomaly anomaly NN cord-014516-r59usk02 437 11 and and CC cord-014516-r59usk02 437 12 CDs cd NNS cord-014516-r59usk02 437 13 , , , cord-014516-r59usk02 437 14 as as RB cord-014516-r59usk02 437 15 well well RB cord-014516-r59usk02 437 16 as as IN cord-014516-r59usk02 437 17 useful useful JJ cord-014516-r59usk02 437 18 to to TO cord-014516-r59usk02 437 19 prognosticate prognosticate VB cord-014516-r59usk02 437 20 long long JJ cord-014516-r59usk02 437 21 - - HYPH cord-014516-r59usk02 437 22 term term NN cord-014516-r59usk02 437 23 outcome outcome NN cord-014516-r59usk02 437 24 and and CC cord-014516-r59usk02 437 25 to to TO cord-014516-r59usk02 437 26 identify identify VB cord-014516-r59usk02 437 27 patients patient NNS cord-014516-r59usk02 437 28 where where WRB cord-014516-r59usk02 437 29 a a DT cord-014516-r59usk02 437 30 surgical surgical JJ cord-014516-r59usk02 437 31 intervention intervention NN cord-014516-r59usk02 437 32 should should MD cord-014516-r59usk02 437 33 be be VB cord-014516-r59usk02 437 34 considered consider VBN cord-014516-r59usk02 437 35 if if IN cord-014516-r59usk02 437 36 available available JJ cord-014516-r59usk02 437 37 . . . cord-014516-r59usk02 438 1 Follow follow VB cord-014516-r59usk02 438 2 - - HYPH cord-014516-r59usk02 438 3 up up RP cord-014516-r59usk02 438 4 echocardiography echocardiography NN cord-014516-r59usk02 438 5 is be VBZ cord-014516-r59usk02 438 6 indicated indicate VBN cord-014516-r59usk02 438 7 to to TO cord-014516-r59usk02 438 8 corroborate corroborate VB cord-014516-r59usk02 438 9 the the DT cord-014516-r59usk02 438 10 prognosis prognosis NN cord-014516-r59usk02 438 11 , , , cord-014516-r59usk02 438 12 to to TO cord-014516-r59usk02 438 13 detect detect VB cord-014516-r59usk02 438 14 complications complication NNS cord-014516-r59usk02 438 15 due due IN cord-014516-r59usk02 438 16 to to IN cord-014516-r59usk02 438 17 the the DT cord-014516-r59usk02 438 18 VSD VSD NNP cord-014516-r59usk02 438 19 and and CC cord-014516-r59usk02 438 20 to to TO cord-014516-r59usk02 438 21 detect detect VB cord-014516-r59usk02 438 22 unassociated unassociated JJ cord-014516-r59usk02 438 23 acquired acquire VBN cord-014516-r59usk02 438 24 cardiac cardiac JJ cord-014516-r59usk02 438 25 diseases disease NNS cord-014516-r59usk02 438 26 . . . cord-014516-r59usk02 439 1 No no DT cord-014516-r59usk02 439 2 conflicts conflict NNS cord-014516-r59usk02 439 3 of of IN cord-014516-r59usk02 439 4 interest interest NN cord-014516-r59usk02 439 5 reported report VBN cord-014516-r59usk02 439 6 . . . cord-014516-r59usk02 440 1 Centronuclear centronuclear NN cord-014516-r59usk02 440 2 myopathy myopathy NN cord-014516-r59usk02 440 3 ( ( -LRB- cord-014516-r59usk02 440 4 CNM CNM NNP cord-014516-r59usk02 440 5 ) ) -RRB- cord-014516-r59usk02 440 6 is be VBZ cord-014516-r59usk02 440 7 the the DT cord-014516-r59usk02 440 8 most most RBS cord-014516-r59usk02 440 9 prevalent prevalent JJ cord-014516-r59usk02 440 10 congenital congenital JJ cord-014516-r59usk02 440 11 inherited inherit VBN cord-014516-r59usk02 440 12 disorder disorder NN cord-014516-r59usk02 440 13 affecting affect VBG cord-014516-r59usk02 440 14 skeletal skeletal JJ cord-014516-r59usk02 440 15 muscles muscle NNS cord-014516-r59usk02 440 16 in in IN cord-014516-r59usk02 440 17 Labrador Labrador NNP cord-014516-r59usk02 440 18 Retrievers Retrievers NNPS cord-014516-r59usk02 440 19 . . . cord-014516-r59usk02 441 1 This this DT cord-014516-r59usk02 441 2 disabling disable VBG cord-014516-r59usk02 441 3 condition condition NN cord-014516-r59usk02 441 4 segregates segregate VBZ cord-014516-r59usk02 441 5 worldwide worldwide RB cord-014516-r59usk02 441 6 and and CC cord-014516-r59usk02 441 7 a a DT cord-014516-r59usk02 441 8 recessive recessive JJ cord-014516-r59usk02 441 9 loss loss NN cord-014516-r59usk02 441 10 - - HYPH cord-014516-r59usk02 441 11 of of IN cord-014516-r59usk02 441 12 - - HYPH cord-014516-r59usk02 441 13 function function NN cord-014516-r59usk02 441 14 founder founder NN cord-014516-r59usk02 441 15 mutation mutation NN cord-014516-r59usk02 441 16 was be VBD cord-014516-r59usk02 441 17 identified identify VBN cord-014516-r59usk02 441 18 in in IN cord-014516-r59usk02 441 19 the the DT cord-014516-r59usk02 441 20 Protein Protein NNP cord-014516-r59usk02 441 21 Tyrosine Tyrosine NNP cord-014516-r59usk02 441 22 Phosphatase Phosphatase NNP cord-014516-r59usk02 441 23 - - HYPH cord-014516-r59usk02 441 24 Like Like NNP cord-014516-r59usk02 441 25 , , , cord-014516-r59usk02 441 26 member member NN cord-014516-r59usk02 441 27 A a DT cord-014516-r59usk02 441 28 gene gene NN cord-014516-r59usk02 441 29 ( ( -LRB- cord-014516-r59usk02 441 30 PTPLA/ PTPLA/ NNP cord-014516-r59usk02 441 31 HACD1 HACD1 NNP cord-014516-r59usk02 441 32 ) ) -RRB- cord-014516-r59usk02 441 33 . . . cord-014516-r59usk02 442 1 The the DT cord-014516-r59usk02 442 2 objectives objective NNS cord-014516-r59usk02 442 3 of of IN cord-014516-r59usk02 442 4 this this DT cord-014516-r59usk02 442 5 study study NN cord-014516-r59usk02 442 6 were be VBD cord-014516-r59usk02 442 7 1 1 CD cord-014516-r59usk02 442 8 ) ) -RRB- cord-014516-r59usk02 442 9 to to TO cord-014516-r59usk02 442 10 describe describe VB cord-014516-r59usk02 442 11 PTPLA PTPLA NNP cord-014516-r59usk02 442 12 expression expression NN cord-014516-r59usk02 442 13 pattern pattern NN cord-014516-r59usk02 442 14 in in IN cord-014516-r59usk02 442 15 hearts heart NNS cord-014516-r59usk02 442 16 from from IN cord-014516-r59usk02 442 17 homozygous homozygous JJ cord-014516-r59usk02 442 18 wild wild JJ cord-014516-r59usk02 442 19 type type NN cord-014516-r59usk02 442 20 ( ( -LRB- cord-014516-r59usk02 442 21 WT WT NNP cord-014516-r59usk02 442 22 ) ) -RRB- cord-014516-r59usk02 442 23 , , , cord-014516-r59usk02 442 24 heterozygous heterozygous JJ cord-014516-r59usk02 442 25 ( ( -LRB- cord-014516-r59usk02 442 26 HET HET NNP cord-014516-r59usk02 442 27 ) ) -RRB- cord-014516-r59usk02 442 28 and and CC cord-014516-r59usk02 442 29 homozygous homozygous JJ cord-014516-r59usk02 442 30 mutated mutate VBN cord-014516-r59usk02 442 31 ( ( -LRB- cord-014516-r59usk02 442 32 CNM CNM NNP cord-014516-r59usk02 442 33 ) ) -RRB- cord-014516-r59usk02 442 34 dogs dog NNS cord-014516-r59usk02 442 35 , , , cord-014516-r59usk02 442 36 2 2 CD cord-014516-r59usk02 442 37 ) ) -RRB- cord-014516-r59usk02 442 38 to to TO cord-014516-r59usk02 442 39 assess assess VB cord-014516-r59usk02 442 40 and and CC cord-014516-r59usk02 442 41 compare compare VB cord-014516-r59usk02 442 42 the the DT cord-014516-r59usk02 442 43 left left JJ cord-014516-r59usk02 442 44 myocardial myocardial JJ cord-014516-r59usk02 442 45 function function NN cord-014516-r59usk02 442 46 in in IN cord-014516-r59usk02 442 47 aging age VBG cord-014516-r59usk02 442 48 WT WT NNP cord-014516-r59usk02 442 49 , , , cord-014516-r59usk02 442 50 HET HET NNP cord-014516-r59usk02 442 51 and and CC cord-014516-r59usk02 442 52 CNM CNM NNP cord-014516-r59usk02 442 53 dogs dog NNS cord-014516-r59usk02 442 54 . . . cord-014516-r59usk02 443 1 For for IN cord-014516-r59usk02 443 2 this this DT cord-014516-r59usk02 443 3 purpose purpose NN cord-014516-r59usk02 443 4 , , , cord-014516-r59usk02 443 5 seven seven CD cord-014516-r59usk02 443 6 WT WT NNP cord-014516-r59usk02 443 7 , , , cord-014516-r59usk02 443 8 four four CD cord-014516-r59usk02 443 9 HET HET NNP cord-014516-r59usk02 443 10 and and CC cord-014516-r59usk02 443 11 eleven eleven CD cord-014516-r59usk02 443 12 CNM CNM NNP cord-014516-r59usk02 443 13 dogs dog NNS cord-014516-r59usk02 443 14 were be VBD cord-014516-r59usk02 443 15 included include VBN cord-014516-r59usk02 443 16 in in IN cord-014516-r59usk02 443 17 the the DT cord-014516-r59usk02 443 18 study study NN cord-014516-r59usk02 443 19 . . . cord-014516-r59usk02 444 1 PTPLA PTPLA NNP cord-014516-r59usk02 444 2 mRNA mRNA NNP cord-014516-r59usk02 444 3 levels level NNS cord-014516-r59usk02 444 4 were be VBD cord-014516-r59usk02 444 5 assessed assess VBN cord-014516-r59usk02 444 6 by by IN cord-014516-r59usk02 444 7 RT RT NNP cord-014516-r59usk02 444 8 - - HYPH cord-014516-r59usk02 444 9 PCR PCR NNP cord-014516-r59usk02 444 10 and and CC cord-014516-r59usk02 444 11 RT RT NNP cord-014516-r59usk02 444 12 - - HYPH cord-014516-r59usk02 444 13 qPCR qPCR NNP cord-014516-r59usk02 444 14 . . . cord-014516-r59usk02 445 1 All all DT cord-014516-r59usk02 445 2 dogs dog NNS cord-014516-r59usk02 445 3 were be VBD cord-014516-r59usk02 445 4 examined examine VBN cord-014516-r59usk02 445 5 using use VBG cord-014516-r59usk02 445 6 conventional conventional JJ cord-014516-r59usk02 445 7 echocardiography echocardiography NN cord-014516-r59usk02 445 8 , , , cord-014516-r59usk02 445 9 2D 2d NN cord-014516-r59usk02 445 10 color color NN cord-014516-r59usk02 445 11 Tissue Tissue NNP cord-014516-r59usk02 445 12 Doppler Doppler NNP cord-014516-r59usk02 445 13 Imaging Imaging NNP cord-014516-r59usk02 445 14 ( ( -LRB- cord-014516-r59usk02 445 15 TDI TDI NNP cord-014516-r59usk02 445 16 ) ) -RRB- cord-014516-r59usk02 445 17 and and CC cord-014516-r59usk02 445 18 TDI tdi NN cord-014516-r59usk02 445 19 - - HYPH cord-014516-r59usk02 445 20 derived derive VBN cord-014516-r59usk02 445 21 strain strain NN cord-014516-r59usk02 445 22 imaging imaging NN cord-014516-r59usk02 445 23 . . . cord-014516-r59usk02 446 1 We -PRON- PRP cord-014516-r59usk02 446 2 found find VBD cord-014516-r59usk02 446 3 that that IN cord-014516-r59usk02 446 4 the the DT cord-014516-r59usk02 446 5 expression expression NN cord-014516-r59usk02 446 6 of of IN cord-014516-r59usk02 446 7 the the DT cord-014516-r59usk02 446 8 two two CD cord-014516-r59usk02 446 9 wild wild JJ cord-014516-r59usk02 446 10 type type NN cord-014516-r59usk02 446 11 PTPLA PTPLA NNP cord-014516-r59usk02 446 12 splice splice NN cord-014516-r59usk02 446 13 isoforms isoform NNS cord-014516-r59usk02 446 14 increased increase VBD cord-014516-r59usk02 446 15 post post NN cord-014516-r59usk02 446 16 - - NN cord-014516-r59usk02 446 17 natally natally RB cord-014516-r59usk02 446 18 in in IN cord-014516-r59usk02 446 19 WT wt NN cord-014516-r59usk02 446 20 dogs dog NNS cord-014516-r59usk02 446 21 . . . cord-014516-r59usk02 447 1 Their -PRON- PRP$ cord-014516-r59usk02 447 2 levels level NNS cord-014516-r59usk02 447 3 were be VBD cord-014516-r59usk02 447 4 halved halve VBN cord-014516-r59usk02 447 5 in in IN cord-014516-r59usk02 447 6 HET HET NNP cord-014516-r59usk02 447 7 dogs dog NNS cord-014516-r59usk02 447 8 and and CC cord-014516-r59usk02 447 9 drastically drastically RB cord-014516-r59usk02 447 10 reduced reduce VBN cord-014516-r59usk02 447 11 in in IN cord-014516-r59usk02 447 12 CNM CNM NNP cord-014516-r59usk02 447 13 dogs dog NNS cord-014516-r59usk02 447 14 . . . cord-014516-r59usk02 448 1 In in IN cord-014516-r59usk02 448 2 both both DT cord-014516-r59usk02 448 3 HET HET NNP cord-014516-r59usk02 448 4 and and CC cord-014516-r59usk02 448 5 CNM CNM NNP cord-014516-r59usk02 448 6 dogs dog NNS cord-014516-r59usk02 448 7 , , , cord-014516-r59usk02 448 8 a a DT cord-014516-r59usk02 448 9 slight slight JJ cord-014516-r59usk02 448 10 left leave VBN cord-014516-r59usk02 448 11 ventricular ventricular JJ cord-014516-r59usk02 448 12 hypertrophy hypertrophy NN cord-014516-r59usk02 448 13 was be VBD cord-014516-r59usk02 448 14 detected detect VBN cord-014516-r59usk02 448 15 using use VBG cord-014516-r59usk02 448 16 conventional conventional JJ cord-014516-r59usk02 448 17 echocardiography echocardiography NN cord-014516-r59usk02 448 18 . . . cord-014516-r59usk02 449 1 TDI TDI NNP cord-014516-r59usk02 449 2 and and CC cord-014516-r59usk02 449 3 strain strain NN cord-014516-r59usk02 449 4 imaging imaging NN cord-014516-r59usk02 449 5 revealed reveal VBD cord-014516-r59usk02 449 6 that that IN cord-014516-r59usk02 449 7 the the DT cord-014516-r59usk02 449 8 left left JJ cord-014516-r59usk02 449 9 ventricular ventricular JJ cord-014516-r59usk02 449 10 myocardial myocardial JJ cord-014516-r59usk02 449 11 function function NN cord-014516-r59usk02 449 12 was be VBD cord-014516-r59usk02 449 13 significantly significantly RB cord-014516-r59usk02 449 14 altered alter VBN cord-014516-r59usk02 449 15 in in IN cord-014516-r59usk02 449 16 both both DT cord-014516-r59usk02 449 17 HET HET NNP cord-014516-r59usk02 449 18 and and CC cord-014516-r59usk02 449 19 CNM CNM NNP cord-014516-r59usk02 449 20 dogs dog NNS cord-014516-r59usk02 449 21 compared compare VBN cord-014516-r59usk02 449 22 to to IN cord-014516-r59usk02 449 23 WT wt NN cord-014516-r59usk02 449 24 dogs dog NNS cord-014516-r59usk02 449 25 . . . cord-014516-r59usk02 450 1 Moreover moreover RB cord-014516-r59usk02 450 2 , , , cord-014516-r59usk02 450 3 these these DT cord-014516-r59usk02 450 4 functional functional JJ cord-014516-r59usk02 450 5 defects defect NNS cord-014516-r59usk02 450 6 were be VBD cord-014516-r59usk02 450 7 associated associate VBN cord-014516-r59usk02 450 8 with with IN cord-014516-r59usk02 450 9 significantly significantly RB cord-014516-r59usk02 450 10 higher high JJR cord-014516-r59usk02 450 11 values value NNS cord-014516-r59usk02 450 12 of of IN cord-014516-r59usk02 450 13 systemic systemic JJ cord-014516-r59usk02 450 14 arterial arterial JJ cord-014516-r59usk02 450 15 blood blood NN cord-014516-r59usk02 450 16 pressure pressure NN cord-014516-r59usk02 450 17 , , , cord-014516-r59usk02 450 18 although although IN cord-014516-r59usk02 450 19 maintained maintain VBN cord-014516-r59usk02 450 20 within within IN cord-014516-r59usk02 450 21 normal normal JJ cord-014516-r59usk02 450 22 ranges range NNS cord-014516-r59usk02 450 23 . . . cord-014516-r59usk02 451 1 In in IN cord-014516-r59usk02 451 2 conclusion conclusion NN cord-014516-r59usk02 451 3 , , , cord-014516-r59usk02 451 4 subclinical subclinical JJ cord-014516-r59usk02 451 5 myocardial myocardial JJ cord-014516-r59usk02 451 6 alterations alteration NNS cord-014516-r59usk02 451 7 were be VBD cord-014516-r59usk02 451 8 detected detect VBN cord-014516-r59usk02 451 9 in in IN cord-014516-r59usk02 451 10 both both DT cord-014516-r59usk02 451 11 HET HET NNP cord-014516-r59usk02 451 12 and and CC cord-014516-r59usk02 451 13 CNM CNM NNP cord-014516-r59usk02 451 14 aging age VBG cord-014516-r59usk02 451 15 dogs dog NNS cord-014516-r59usk02 451 16 from from IN cord-014516-r59usk02 451 17 our -PRON- PRP$ cord-014516-r59usk02 451 18 French french JJ cord-014516-r59usk02 451 19 pedigree pedigree NN cord-014516-r59usk02 451 20 , , , cord-014516-r59usk02 451 21 suggesting suggest VBG cord-014516-r59usk02 451 22 a a DT cord-014516-r59usk02 451 23 role role NN cord-014516-r59usk02 451 24 for for IN cord-014516-r59usk02 451 25 PTPLA PTPLA NNP cord-014516-r59usk02 451 26 in in IN cord-014516-r59usk02 451 27 long long JJ cord-014516-r59usk02 451 28 - - HYPH cord-014516-r59usk02 451 29 term term NN cord-014516-r59usk02 451 30 cardiovascular cardiovascular JJ cord-014516-r59usk02 451 31 homeostasis homeostasis NN cord-014516-r59usk02 451 32 . . . cord-014516-r59usk02 452 1 These these DT cord-014516-r59usk02 452 2 findings finding NNS cord-014516-r59usk02 452 3 prompt prompt VBP cord-014516-r59usk02 452 4 globalized globalized JJ cord-014516-r59usk02 452 5 confirmation confirmation NN cord-014516-r59usk02 452 6 in in IN cord-014516-r59usk02 452 7 additional additional JJ cord-014516-r59usk02 452 8 PTPLA"'deficient ptpla"'deficient JJ cord-014516-r59usk02 452 9 dogs dog NNS cord-014516-r59usk02 452 10 , , , cord-014516-r59usk02 452 11 which which WDT cord-014516-r59usk02 452 12 may may MD cord-014516-r59usk02 452 13 thus thus RB cord-014516-r59usk02 452 14 be be VB cord-014516-r59usk02 452 15 considered consider VBN cord-014516-r59usk02 452 16 as as IN cord-014516-r59usk02 452 17 a a DT cord-014516-r59usk02 452 18 new new JJ cord-014516-r59usk02 452 19 large large JJ cord-014516-r59usk02 452 20 - - HYPH cord-014516-r59usk02 452 21 size size NN cord-014516-r59usk02 452 22 model model NN cord-014516-r59usk02 452 23 for for IN cord-014516-r59usk02 452 24 human human JJ cord-014516-r59usk02 452 25 left left JJ cord-014516-r59usk02 452 26 ventricular ventricular JJ cord-014516-r59usk02 452 27 sub sub JJ cord-014516-r59usk02 452 28 - - JJ cord-014516-r59usk02 452 29 clinical clinical JJ cord-014516-r59usk02 452 30 myocardial myocardial JJ cord-014516-r59usk02 452 31 dysfunction dysfunction NN cord-014516-r59usk02 452 32 . . . cord-014516-r59usk02 453 1 No no DT cord-014516-r59usk02 453 2 conflicts conflict NNS cord-014516-r59usk02 453 3 of of IN cord-014516-r59usk02 453 4 interest interest NN cord-014516-r59usk02 453 5 reported report VBN cord-014516-r59usk02 453 6 . . . cord-014516-r59usk02 454 1 Mitral mitral JJ cord-014516-r59usk02 454 2 regurgitation regurgitation NN cord-014516-r59usk02 454 3 ( ( -LRB- cord-014516-r59usk02 454 4 MR MR NNP cord-014516-r59usk02 454 5 ) ) -RRB- cord-014516-r59usk02 454 6 secondary secondary JJ cord-014516-r59usk02 454 7 to to IN cord-014516-r59usk02 454 8 degenerative degenerative JJ cord-014516-r59usk02 454 9 mitral mitral JJ cord-014516-r59usk02 454 10 valve valve NN cord-014516-r59usk02 454 11 disease disease NN cord-014516-r59usk02 454 12 ( ( -LRB- cord-014516-r59usk02 454 13 DMVD DMVD NNP cord-014516-r59usk02 454 14 ) ) -RRB- cord-014516-r59usk02 454 15 is be VBZ cord-014516-r59usk02 454 16 the the DT cord-014516-r59usk02 454 17 most most RBS cord-014516-r59usk02 454 18 common common JJ cord-014516-r59usk02 454 19 heart heart NN cord-014516-r59usk02 454 20 disease disease NN cord-014516-r59usk02 454 21 in in IN cord-014516-r59usk02 454 22 dogs dog NNS cord-014516-r59usk02 454 23 . . . cord-014516-r59usk02 455 1 In in IN cord-014516-r59usk02 455 2 dogs dog NNS cord-014516-r59usk02 455 3 with with IN cord-014516-r59usk02 455 4 MR MR NNP cord-014516-r59usk02 455 5 , , , cord-014516-r59usk02 455 6 mitral mitral JJ cord-014516-r59usk02 455 7 valve valve NN cord-014516-r59usk02 455 8 prolapse prolapse NN cord-014516-r59usk02 455 9 caused cause VBN cord-014516-r59usk02 455 10 by by IN cord-014516-r59usk02 455 11 degeneration degeneration NN cord-014516-r59usk02 455 12 of of IN cord-014516-r59usk02 455 13 the the DT cord-014516-r59usk02 455 14 mitral mitral JJ cord-014516-r59usk02 455 15 valve valve NN cord-014516-r59usk02 455 16 leaflet leaflet NN cord-014516-r59usk02 455 17 , , , cord-014516-r59usk02 455 18 chordae chordae NNP cord-014516-r59usk02 455 19 tendinae tendinae NNP cord-014516-r59usk02 455 20 extension extension NN cord-014516-r59usk02 455 21 and/or and/or CC cord-014516-r59usk02 455 22 rupture rupture NN cord-014516-r59usk02 455 23 and and CC cord-014516-r59usk02 455 24 mitral mitral JJ cord-014516-r59usk02 455 25 annulus annulus NN cord-014516-r59usk02 455 26 dilation dilation NN cord-014516-r59usk02 455 27 are be VBP cord-014516-r59usk02 455 28 observed observe VBN cord-014516-r59usk02 455 29 . . . cord-014516-r59usk02 456 1 However however RB cord-014516-r59usk02 456 2 , , , cord-014516-r59usk02 456 3 limited limited JJ cord-014516-r59usk02 456 4 data datum NNS cord-014516-r59usk02 456 5 are be VBP cord-014516-r59usk02 456 6 available available JJ cord-014516-r59usk02 456 7 on on IN cord-014516-r59usk02 456 8 morphological morphological JJ cord-014516-r59usk02 456 9 changes change NNS cord-014516-r59usk02 456 10 in in IN cord-014516-r59usk02 456 11 dogs dog NNS cord-014516-r59usk02 456 12 with with IN cord-014516-r59usk02 456 13 MR MR NNP cord-014516-r59usk02 456 14 . . . cord-014516-r59usk02 457 1 Currently currently RB cord-014516-r59usk02 457 2 , , , cord-014516-r59usk02 457 3 there there EX cord-014516-r59usk02 457 4 are be VBP cord-014516-r59usk02 457 5 no no DT cord-014516-r59usk02 457 6 studies study NNS cord-014516-r59usk02 457 7 confirming confirm VBG cord-014516-r59usk02 457 8 the the DT cord-014516-r59usk02 457 9 anomaly anomaly NN cord-014516-r59usk02 457 10 of of IN cord-014516-r59usk02 457 11 the the DT cord-014516-r59usk02 457 12 mitral mitral JJ cord-014516-r59usk02 457 13 complex complex NN cord-014516-r59usk02 457 14 via via IN cord-014516-r59usk02 457 15 direct direct JJ cord-014516-r59usk02 457 16 observation observation NN cord-014516-r59usk02 457 17 in in IN cord-014516-r59usk02 457 18 living live VBG cord-014516-r59usk02 457 19 dogs dog NNS cord-014516-r59usk02 457 20 with with IN cord-014516-r59usk02 457 21 mitral mitral JJ cord-014516-r59usk02 457 22 regurgitation regurgitation NN cord-014516-r59usk02 457 23 . . . cord-014516-r59usk02 458 1 At at IN cord-014516-r59usk02 458 2 our -PRON- PRP$ cord-014516-r59usk02 458 3 institution institution NN cord-014516-r59usk02 458 4 over over IN cord-014516-r59usk02 458 5 the the DT cord-014516-r59usk02 458 6 last last JJ cord-014516-r59usk02 458 7 ten ten CD cord-014516-r59usk02 458 8 years year NNS cord-014516-r59usk02 458 9 , , , cord-014516-r59usk02 458 10 approximately approximately RB cord-014516-r59usk02 458 11 300 300 CD cord-014516-r59usk02 458 12 dogs dog NNS cord-014516-r59usk02 458 13 have have VBP cord-014516-r59usk02 458 14 undergone undergo VBN cord-014516-r59usk02 458 15 mitral mitral JJ cord-014516-r59usk02 458 16 valve valve NN cord-014516-r59usk02 458 17 repair repair NN cord-014516-r59usk02 458 18 . . . cord-014516-r59usk02 459 1 During during IN cord-014516-r59usk02 459 2 surgery surgery NN cord-014516-r59usk02 459 3 , , , cord-014516-r59usk02 459 4 the the DT cord-014516-r59usk02 459 5 anomaly anomaly NN cord-014516-r59usk02 459 6 of of IN cord-014516-r59usk02 459 7 mitral mitral JJ cord-014516-r59usk02 459 8 complex complex NN cord-014516-r59usk02 459 9 can can MD cord-014516-r59usk02 459 10 be be VB cord-014516-r59usk02 459 11 observed observe VBN cord-014516-r59usk02 459 12 macroscopically macroscopically RB cord-014516-r59usk02 459 13 ( ( -LRB- cord-014516-r59usk02 459 14 directly directly RB cord-014516-r59usk02 459 15 visualized visualize VBN cord-014516-r59usk02 459 16 ) ) -RRB- cord-014516-r59usk02 459 17 . . . cord-014516-r59usk02 460 1 To to IN cord-014516-r59usk02 460 2 our -PRON- PRP$ cord-014516-r59usk02 460 3 knowledge knowledge NN cord-014516-r59usk02 460 4 , , , cord-014516-r59usk02 460 5 this this DT cord-014516-r59usk02 460 6 is be VBZ cord-014516-r59usk02 460 7 the the DT cord-014516-r59usk02 460 8 first first JJ cord-014516-r59usk02 460 9 study study NN cord-014516-r59usk02 460 10 evaluating evaluate VBG cord-014516-r59usk02 460 11 the the DT cord-014516-r59usk02 460 12 anomaly anomaly NN cord-014516-r59usk02 460 13 of of IN cord-014516-r59usk02 460 14 the the DT cord-014516-r59usk02 460 15 mitral mitral JJ cord-014516-r59usk02 460 16 valve valve NN cord-014516-r59usk02 460 17 leaflet leaflet NN cord-014516-r59usk02 460 18 and and CC cord-014516-r59usk02 460 19 chordae chordae NNP cord-014516-r59usk02 460 20 tendineae tendineae NNP cord-014516-r59usk02 460 21 in in IN cord-014516-r59usk02 460 22 dogs dog NNS cord-014516-r59usk02 460 23 undergoing undergo VBG cord-014516-r59usk02 460 24 mitral mitral JJ cord-014516-r59usk02 460 25 valve valve NN cord-014516-r59usk02 460 26 repair repair NN cord-014516-r59usk02 460 27 . . . cord-014516-r59usk02 461 1 Animals animal NNS cord-014516-r59usk02 461 2 : : : cord-014516-r59usk02 461 3 Dogs dog NNS cord-014516-r59usk02 461 4 that that WDT cord-014516-r59usk02 461 5 underwent undergo VBD cord-014516-r59usk02 461 6 mitral mitral JJ cord-014516-r59usk02 461 7 valve valve NN cord-014516-r59usk02 461 8 repair repair NN cord-014516-r59usk02 461 9 with with IN cord-014516-r59usk02 461 10 CPB CPB NNP cord-014516-r59usk02 461 11 at at IN cord-014516-r59usk02 461 12 Nihon Nihon NNP cord-014516-r59usk02 461 13 University University NNP cord-014516-r59usk02 461 14 between between IN cord-014516-r59usk02 461 15 February February NNP cord-014516-r59usk02 461 16 2010 2010 CD cord-014516-r59usk02 461 17 and and CC cord-014516-r59usk02 461 18 June June NNP cord-014516-r59usk02 461 19 2013 2013 CD cord-014516-r59usk02 461 20 were be VBD cord-014516-r59usk02 461 21 included include VBN cord-014516-r59usk02 461 22 in in IN cord-014516-r59usk02 461 23 this this DT cord-014516-r59usk02 461 24 study study NN cord-014516-r59usk02 461 25 . . . cord-014516-r59usk02 462 1 Methods method NNS cord-014516-r59usk02 462 2 : : : cord-014516-r59usk02 462 3 Confirmation Confirmation NNP cord-014516-r59usk02 462 4 of of IN cord-014516-r59usk02 462 5 chordae chordae NNP cord-014516-r59usk02 462 6 tendineae tendineae NNP cord-014516-r59usk02 462 7 rupture rupture NN cord-014516-r59usk02 462 8 was be VBD cord-014516-r59usk02 462 9 visually visually RB cord-014516-r59usk02 462 10 confirmed confirm VBN cord-014516-r59usk02 462 11 during during IN cord-014516-r59usk02 462 12 surgery surgery NN cord-014516-r59usk02 462 13 . . . cord-014516-r59usk02 463 1 The the DT cord-014516-r59usk02 463 2 sites site NNS cord-014516-r59usk02 463 3 of of IN cord-014516-r59usk02 463 4 chordae chordae NNP cord-014516-r59usk02 463 5 tendineae tendineae NNP cord-014516-r59usk02 463 6 rupture rupture NN cord-014516-r59usk02 463 7 were be VBD cord-014516-r59usk02 463 8 also also RB cord-014516-r59usk02 463 9 recorded record VBN cord-014516-r59usk02 463 10 at at IN cord-014516-r59usk02 463 11 that that DT cord-014516-r59usk02 463 12 time time NN cord-014516-r59usk02 463 13 . . . cord-014516-r59usk02 464 1 Septal Septal NNP cord-014516-r59usk02 464 2 chordae chordae NNP cord-014516-r59usk02 464 3 and and CC cord-014516-r59usk02 464 4 mural mural NNP cord-014516-r59usk02 464 5 chordae chordae NNP cord-014516-r59usk02 464 6 were be VBD cord-014516-r59usk02 464 7 divided divide VBN cord-014516-r59usk02 464 8 three three CD cord-014516-r59usk02 464 9 division division NN cord-014516-r59usk02 464 10 depend depend VB cord-014516-r59usk02 464 11 on on IN cord-014516-r59usk02 464 12 the the DT cord-014516-r59usk02 464 13 site site NN cord-014516-r59usk02 464 14 ( ( -LRB- cord-014516-r59usk02 464 15 S1 S1 NNP cord-014516-r59usk02 464 16 , , , cord-014516-r59usk02 464 17 S2 S2 NNP cord-014516-r59usk02 464 18 , , , cord-014516-r59usk02 464 19 S3 S3 NNP cord-014516-r59usk02 464 20 and and CC cord-014516-r59usk02 464 21 M1 M1 NNP cord-014516-r59usk02 464 22 , , , cord-014516-r59usk02 464 23 M2 M2 NNP cord-014516-r59usk02 464 24 , , , cord-014516-r59usk02 464 25 M3 M3 NNP cord-014516-r59usk02 464 26 respectively respectively RB cord-014516-r59usk02 464 27 ) ) -RRB- cord-014516-r59usk02 464 28 . . . cord-014516-r59usk02 465 1 Results result NNS cord-014516-r59usk02 465 2 : : : cord-014516-r59usk02 466 1 Ninety ninety CD cord-014516-r59usk02 466 2 eight eight CD cord-014516-r59usk02 466 3 dogs dog NNS cord-014516-r59usk02 466 4 were be VBD cord-014516-r59usk02 466 5 included include VBN cord-014516-r59usk02 466 6 in in IN cord-014516-r59usk02 466 7 this this DT cord-014516-r59usk02 466 8 study study NN cord-014516-r59usk02 466 9 . . . cord-014516-r59usk02 467 1 The the DT cord-014516-r59usk02 467 2 mean mean JJ cord-014516-r59usk02 467 3 age age NN cord-014516-r59usk02 467 4 and and CC cord-014516-r59usk02 467 5 body body NN cord-014516-r59usk02 467 6 weight weight NN cord-014516-r59usk02 467 7 were be VBD cord-014516-r59usk02 467 8 8.8 8.8 CD cord-014516-r59usk02 467 9 AE AE NNP cord-014516-r59usk02 467 10 1.8 1.8 CD cord-014516-r59usk02 467 11 years year NNS cord-014516-r59usk02 467 12 and and CC cord-014516-r59usk02 467 13 5.15 5.15 CD cord-014516-r59usk02 467 14 AE AE NNP cord-014516-r59usk02 467 15 3.24 3.24 CD cord-014516-r59usk02 467 16 kg kg NNS cord-014516-r59usk02 467 17 , , , cord-014516-r59usk02 467 18 respectively respectively RB cord-014516-r59usk02 467 19 . . . cord-014516-r59usk02 468 1 Of of IN cord-014516-r59usk02 468 2 the the DT cord-014516-r59usk02 468 3 98 98 CD cord-014516-r59usk02 468 4 dogs dog NNS cord-014516-r59usk02 468 5 , , , cord-014516-r59usk02 468 6 ruptured rupture VBD cord-014516-r59usk02 468 7 chordae chordae NN cord-014516-r59usk02 468 8 was be VBD cord-014516-r59usk02 468 9 observed observe VBN cord-014516-r59usk02 468 10 in in IN cord-014516-r59usk02 468 11 80 80 CD cord-014516-r59usk02 468 12 dogs dog NNS cord-014516-r59usk02 468 13 ( ( -LRB- cord-014516-r59usk02 468 14 81.6 81.6 CD cord-014516-r59usk02 468 15 % % NN cord-014516-r59usk02 468 16 ) ) -RRB- cord-014516-r59usk02 468 17 . . . cord-014516-r59usk02 469 1 Septal Septal NNP cord-014516-r59usk02 469 2 leaflet leaflet NN cord-014516-r59usk02 469 3 chordae chordae NNP cord-014516-r59usk02 469 4 was be VBD cord-014516-r59usk02 469 5 ruptured rupture VBN cord-014516-r59usk02 469 6 in in IN cord-014516-r59usk02 469 7 73 73 CD cord-014516-r59usk02 469 8 dogs dog NNS cord-014516-r59usk02 469 9 ( ( -LRB- cord-014516-r59usk02 469 10 74.5 74.5 CD cord-014516-r59usk02 469 11 % % NN cord-014516-r59usk02 469 12 ) ) -RRB- cord-014516-r59usk02 469 13 and and CC cord-014516-r59usk02 469 14 mural mural NN cord-014516-r59usk02 469 15 leaflet leaflet NN cord-014516-r59usk02 469 16 chordae chordae NNP cord-014516-r59usk02 469 17 was be VBD cord-014516-r59usk02 469 18 ruptured rupture VBN cord-014516-r59usk02 469 19 in in IN cord-014516-r59usk02 469 20 25 25 CD cord-014516-r59usk02 469 21 dogs dog NNS cord-014516-r59usk02 469 22 ( ( -LRB- cord-014516-r59usk02 469 23 25.5 25.5 CD cord-014516-r59usk02 469 24 % % NN cord-014516-r59usk02 469 25 ) ) -RRB- cord-014516-r59usk02 469 26 . . . cord-014516-r59usk02 470 1 Chordae Chordae NNP cord-014516-r59usk02 470 2 of of IN cord-014516-r59usk02 470 3 both both DT cord-014516-r59usk02 470 4 leaflets leaflet NNS cord-014516-r59usk02 470 5 were be VBD cord-014516-r59usk02 470 6 ruptured rupture VBN cord-014516-r59usk02 470 7 in in IN cord-014516-r59usk02 470 8 18 18 CD cord-014516-r59usk02 470 9 dogs dog NNS cord-014516-r59usk02 470 10 ( ( -LRB- cord-014516-r59usk02 470 11 18.4 18.4 CD cord-014516-r59usk02 470 12 % % NN cord-014516-r59usk02 470 13 ) ) -RRB- cord-014516-r59usk02 470 14 . . . cord-014516-r59usk02 471 1 No no DT cord-014516-r59usk02 471 2 chordal chordal JJ cord-014516-r59usk02 471 3 rupture rupture NN cord-014516-r59usk02 471 4 was be VBD cord-014516-r59usk02 471 5 observed observe VBN cord-014516-r59usk02 471 6 in in IN cord-014516-r59usk02 471 7 18 18 CD cord-014516-r59usk02 471 8 dogs dog NNS cord-014516-r59usk02 471 9 ( ( -LRB- cord-014516-r59usk02 471 10 18.4 18.4 CD cord-014516-r59usk02 471 11 % % NN cord-014516-r59usk02 471 12 ) ) -RRB- cord-014516-r59usk02 471 13 . . . cord-014516-r59usk02 472 1 In in IN cord-014516-r59usk02 472 2 the the DT cord-014516-r59usk02 472 3 dogs dog NNS cord-014516-r59usk02 472 4 with with IN cord-014516-r59usk02 472 5 ruptured ruptured JJ cord-014516-r59usk02 472 6 septal septal JJ cord-014516-r59usk02 472 7 chordae chordae NN cord-014516-r59usk02 472 8 , , , cord-014516-r59usk02 472 9 the the DT cord-014516-r59usk02 472 10 chordae chordae NN cord-014516-r59usk02 472 11 between between IN cord-014516-r59usk02 472 12 S2 S2 NNP cord-014516-r59usk02 472 13 and and CC cord-014516-r59usk02 472 14 S3 S3 NNP cord-014516-r59usk02 472 15 was be VBD cord-014516-r59usk02 472 16 most most RBS cord-014516-r59usk02 472 17 often often RB cord-014516-r59usk02 472 18 ruptured rupture VBN cord-014516-r59usk02 472 19 ( ( -LRB- cord-014516-r59usk02 472 20 n n NN cord-014516-r59usk02 472 21 = = SYM cord-014516-r59usk02 472 22 37 37 CD cord-014516-r59usk02 472 23 , , , cord-014516-r59usk02 472 24 51 51 CD cord-014516-r59usk02 472 25 % % NN cord-014516-r59usk02 472 26 ) ) -RRB- cord-014516-r59usk02 472 27 . . . cord-014516-r59usk02 473 1 In in IN cord-014516-r59usk02 473 2 this this DT cord-014516-r59usk02 473 3 study study NN cord-014516-r59usk02 473 4 , , , cord-014516-r59usk02 473 5 rupture rupture NN cord-014516-r59usk02 473 6 of of IN cord-014516-r59usk02 473 7 the the DT cord-014516-r59usk02 473 8 septal septal JJ cord-014516-r59usk02 473 9 chordae chordae NNP cord-014516-r59usk02 473 10 tendineae tendineae NNP cord-014516-r59usk02 473 11 was be VBD cord-014516-r59usk02 473 12 most most RBS cord-014516-r59usk02 473 13 commonly commonly RB cord-014516-r59usk02 473 14 observed observe VBN cord-014516-r59usk02 473 15 . . . cord-014516-r59usk02 474 1 This this DT cord-014516-r59usk02 474 2 is be VBZ cord-014516-r59usk02 474 3 the the DT cord-014516-r59usk02 474 4 first first JJ cord-014516-r59usk02 474 5 pilot pilot NN cord-014516-r59usk02 474 6 study study NN cord-014516-r59usk02 474 7 to to TO cord-014516-r59usk02 474 8 visually visually RB cord-014516-r59usk02 474 9 evaluate evaluate VB cord-014516-r59usk02 474 10 the the DT cord-014516-r59usk02 474 11 anomaly anomaly NN cord-014516-r59usk02 474 12 of of IN cord-014516-r59usk02 474 13 the the DT cord-014516-r59usk02 474 14 mitral mitral JJ cord-014516-r59usk02 474 15 valve valve NN cord-014516-r59usk02 474 16 leaflet leaflet NN cord-014516-r59usk02 474 17 and and CC cord-014516-r59usk02 474 18 chordae chordae NNP cord-014516-r59usk02 474 19 tendineae tendineae NNP cord-014516-r59usk02 474 20 in in IN cord-014516-r59usk02 474 21 dogs dog NNS cord-014516-r59usk02 474 22 undergoing undergo VBG cord-014516-r59usk02 474 23 mitral mitral JJ cord-014516-r59usk02 474 24 valve valve NN cord-014516-r59usk02 474 25 repair repair NN cord-014516-r59usk02 474 26 . . . cord-014516-r59usk02 475 1 Future future JJ cord-014516-r59usk02 475 2 studies study NNS cord-014516-r59usk02 475 3 comparing compare VBG cord-014516-r59usk02 475 4 pathological pathological JJ cord-014516-r59usk02 475 5 changes change NNS cord-014516-r59usk02 475 6 and and CC cord-014516-r59usk02 475 7 molecular molecular JJ cord-014516-r59usk02 475 8 biological biological JJ cord-014516-r59usk02 475 9 analysis analysis NN cord-014516-r59usk02 475 10 to to IN cord-014516-r59usk02 475 11 gross gross JJ cord-014516-r59usk02 475 12 findings finding NNS cord-014516-r59usk02 475 13 of of IN cord-014516-r59usk02 475 14 mitral mitral JJ cord-014516-r59usk02 475 15 chordae chordae VBN cord-014516-r59usk02 475 16 tendineae tendineae NN cord-014516-r59usk02 475 17 in in IN cord-014516-r59usk02 475 18 dogs dog NNS cord-014516-r59usk02 475 19 undergoing undergo VBG cord-014516-r59usk02 475 20 mitral mitral JJ cord-014516-r59usk02 475 21 valve valve NN cord-014516-r59usk02 475 22 repair repair NN cord-014516-r59usk02 475 23 may may MD cord-014516-r59usk02 475 24 be be VB cord-014516-r59usk02 475 25 useful useful JJ cord-014516-r59usk02 475 26 in in IN cord-014516-r59usk02 475 27 advancing advance VBG cord-014516-r59usk02 475 28 the the DT cord-014516-r59usk02 475 29 understanding understanding NN cord-014516-r59usk02 475 30 of of IN cord-014516-r59usk02 475 31 the the DT cord-014516-r59usk02 475 32 disease disease NN cord-014516-r59usk02 475 33 . . . cord-014516-r59usk02 476 1 No no DT cord-014516-r59usk02 476 2 conflicts conflict NNS cord-014516-r59usk02 476 3 of of IN cord-014516-r59usk02 476 4 interest interest NN cord-014516-r59usk02 476 5 reported report VBN cord-014516-r59usk02 476 6 . . . cord-014516-r59usk02 477 1 Echocardiographic echocardiographic JJ cord-014516-r59usk02 477 2 aortic aortic JJ cord-014516-r59usk02 477 3 valve valve NN cord-014516-r59usk02 477 4 ( ( -LRB- cord-014516-r59usk02 477 5 Ao Ao NNP cord-014516-r59usk02 477 6 ) ) -RRB- cord-014516-r59usk02 477 7 measurements measurement NNS cord-014516-r59usk02 477 8 are be VBP cord-014516-r59usk02 477 9 routinely routinely RB cord-014516-r59usk02 477 10 obtained obtain VBN cord-014516-r59usk02 477 11 during during IN cord-014516-r59usk02 477 12 cardiac cardiac JJ cord-014516-r59usk02 477 13 evaluation evaluation NN cord-014516-r59usk02 477 14 of of IN cord-014516-r59usk02 477 15 patients patient NNS cord-014516-r59usk02 477 16 . . . cord-014516-r59usk02 478 1 Cardiologists cardiologist NNS cord-014516-r59usk02 478 2 commonly commonly RB cord-014516-r59usk02 478 3 use use VBP cord-014516-r59usk02 478 4 diastolic diastolic JJ cord-014516-r59usk02 478 5 Ao Ao NNP cord-014516-r59usk02 478 6 measurements measurement NNS cord-014516-r59usk02 478 7 to to TO cord-014516-r59usk02 478 8 obtain obtain VB cord-014516-r59usk02 478 9 ratiometric ratiometric JJ cord-014516-r59usk02 478 10 weight weight NN cord-014516-r59usk02 478 11 - - HYPH cord-014516-r59usk02 478 12 independent independent JJ cord-014516-r59usk02 478 13 estimates estimate NNS cord-014516-r59usk02 478 14 of of IN cord-014516-r59usk02 478 15 dimensions dimension NNS cord-014516-r59usk02 478 16 of of IN cord-014516-r59usk02 478 17 other other JJ cord-014516-r59usk02 478 18 cardiac cardiac JJ cord-014516-r59usk02 478 19 structures structure NNS cord-014516-r59usk02 478 20 , , , cord-014516-r59usk02 478 21 most most RBS cord-014516-r59usk02 478 22 commonly commonly RB cord-014516-r59usk02 478 23 the the DT cord-014516-r59usk02 478 24 left left JJ cord-014516-r59usk02 478 25 atrium atrium NN cord-014516-r59usk02 478 26 ( ( -LRB- cord-014516-r59usk02 478 27 LA LA NNP cord-014516-r59usk02 478 28 ) ) -RRB- cord-014516-r59usk02 478 29 . . . cord-014516-r59usk02 479 1 However however RB cord-014516-r59usk02 479 2 , , , cord-014516-r59usk02 479 3 no no DT cord-014516-r59usk02 479 4 consensus consensus NN cord-014516-r59usk02 479 5 exists exist VBZ cord-014516-r59usk02 479 6 about about IN cord-014516-r59usk02 479 7 the the DT cord-014516-r59usk02 479 8 point point NN cord-014516-r59usk02 479 9 in in IN cord-014516-r59usk02 479 10 diastole diastole NN cord-014516-r59usk02 479 11 at at IN cord-014516-r59usk02 479 12 which which WDT cord-014516-r59usk02 479 13 Ao ao NN cord-014516-r59usk02 479 14 measurements measurement NNS cord-014516-r59usk02 479 15 should should MD cord-014516-r59usk02 479 16 be be VB cord-014516-r59usk02 479 17 obtained obtain VBN cord-014516-r59usk02 479 18 -immediately -immediately RB cord-014516-r59usk02 479 19 after after IN cord-014516-r59usk02 479 20 closure closure NN cord-014516-r59usk02 479 21 of of IN cord-014516-r59usk02 479 22 the the DT cord-014516-r59usk02 479 23 aortic aortic JJ cord-014516-r59usk02 479 24 valve valve NN cord-014516-r59usk02 479 25 , , , cord-014516-r59usk02 479 26 when when WRB cord-014516-r59usk02 479 27 LA LA NNP cord-014516-r59usk02 479 28 size size NN cord-014516-r59usk02 479 29 is be VBZ cord-014516-r59usk02 479 30 largest large JJS cord-014516-r59usk02 479 31 ( ( -LRB- cord-014516-r59usk02 479 32 Ao Ao NNP cord-014516-r59usk02 479 33 MAX MAX NNP cord-014516-r59usk02 479 34 , , , cord-014516-r59usk02 479 35 but but CC cord-014516-r59usk02 479 36 often often RB cord-014516-r59usk02 479 37 with with IN cord-014516-r59usk02 479 38 least least JJS cord-014516-r59usk02 479 39 distinct distinct JJ cord-014516-r59usk02 479 40 margins margin NNS cord-014516-r59usk02 479 41 ) ) -RRB- cord-014516-r59usk02 479 42 , , , cord-014516-r59usk02 479 43 during during IN cord-014516-r59usk02 479 44 the the DT cord-014516-r59usk02 479 45 P p NN cord-014516-r59usk02 479 46 - - HYPH cord-014516-r59usk02 479 47 wave wave NN cord-014516-r59usk02 479 48 of of IN cord-014516-r59usk02 479 49 the the DT cord-014516-r59usk02 479 50 ECG ECG NNP cord-014516-r59usk02 479 51 ( ( -LRB- cord-014516-r59usk02 479 52 Ao Ao NNP cord-014516-r59usk02 479 53 P P NNP cord-014516-r59usk02 479 54 ) ) -RRB- cord-014516-r59usk02 479 55 and and CC cord-014516-r59usk02 479 56 at at IN cord-014516-r59usk02 479 57 the the DT cord-014516-r59usk02 479 58 onset onset NN cord-014516-r59usk02 479 59 of of IN cord-014516-r59usk02 479 60 ventricular ventricular JJ cord-014516-r59usk02 479 61 electrical electrical JJ cord-014516-r59usk02 479 62 systole systole NN cord-014516-r59usk02 479 63 , , , cord-014516-r59usk02 479 64 when when WRB cord-014516-r59usk02 479 65 LA LA NNP cord-014516-r59usk02 479 66 size size NN cord-014516-r59usk02 479 67 is be VBZ cord-014516-r59usk02 479 68 smallest small JJS cord-014516-r59usk02 479 69 ( ( -LRB- cord-014516-r59usk02 479 70 Ao Ao NNP cord-014516-r59usk02 479 71 MIN MIN NNP cord-014516-r59usk02 479 72 ) ) -RRB- cord-014516-r59usk02 479 73 . . . cord-014516-r59usk02 480 1 We -PRON- PRP cord-014516-r59usk02 480 2 examined examine VBD cord-014516-r59usk02 480 3 the the DT cord-014516-r59usk02 480 4 linear linear JJ cord-014516-r59usk02 480 5 and and CC cord-014516-r59usk02 480 6 area area NN cord-014516-r59usk02 480 7 dimensions dimension NNS cord-014516-r59usk02 480 8 of of IN cord-014516-r59usk02 480 9 the the DT cord-014516-r59usk02 480 10 Ao Ao NNP cord-014516-r59usk02 480 11 ( ( -LRB- cord-014516-r59usk02 480 12 AoD aod NN cord-014516-r59usk02 480 13 and and CC cord-014516-r59usk02 480 14 AoA AoA NNP cord-014516-r59usk02 480 15 ) ) -RRB- cord-014516-r59usk02 480 16 to to TO cord-014516-r59usk02 480 17 determine determine VB cord-014516-r59usk02 480 18 if if IN cord-014516-r59usk02 480 19 clinically clinically RB cord-014516-r59usk02 480 20 significant significant JJ cord-014516-r59usk02 480 21 differences difference NNS cord-014516-r59usk02 480 22 exist exist VBP cord-014516-r59usk02 480 23 at at IN cord-014516-r59usk02 480 24 3 3 CD cord-014516-r59usk02 480 25 distinct distinct JJ cord-014516-r59usk02 480 26 diastolic diastolic JJ cord-014516-r59usk02 480 27 time time NN cord-014516-r59usk02 480 28 - - HYPH cord-014516-r59usk02 480 29 points point NNS cord-014516-r59usk02 480 30 , , , cord-014516-r59usk02 480 31 or or CC cord-014516-r59usk02 480 32 if if IN cord-014516-r59usk02 480 33 these these DT cord-014516-r59usk02 480 34 measurements measurement NNS cord-014516-r59usk02 480 35 could could MD cord-014516-r59usk02 480 36 be be VB cord-014516-r59usk02 480 37 interchangeable interchangeable JJ cord-014516-r59usk02 480 38 . . . cord-014516-r59usk02 481 1 We -PRON- PRP cord-014516-r59usk02 481 2 examined examine VBD cord-014516-r59usk02 481 3 130 130 CD cord-014516-r59usk02 481 4 patients patient NNS cord-014516-r59usk02 481 5 ( ( -LRB- cord-014516-r59usk02 481 6 114 114 CD cord-014516-r59usk02 481 7 dogs dog NNS cord-014516-r59usk02 481 8 and and CC cord-014516-r59usk02 481 9 16 16 CD cord-014516-r59usk02 481 10 cats cat NNS cord-014516-r59usk02 481 11 ) ) -RRB- cord-014516-r59usk02 481 12 presented present VBD cord-014516-r59usk02 481 13 for for IN cord-014516-r59usk02 481 14 cardiac cardiac JJ cord-014516-r59usk02 481 15 evaluations evaluation NNS cord-014516-r59usk02 481 16 by by IN cord-014516-r59usk02 481 17 2D 2d NN cord-014516-r59usk02 481 18 echocardiography echocardiography NN cord-014516-r59usk02 481 19 . . . cord-014516-r59usk02 482 1 Three three CD cord-014516-r59usk02 482 2 replicates replicate NNS cord-014516-r59usk02 482 3 of of IN cord-014516-r59usk02 482 4 each each DT cord-014516-r59usk02 482 5 time time NN cord-014516-r59usk02 482 6 - - HYPH cord-014516-r59usk02 482 7 point point NN cord-014516-r59usk02 482 8 linear linear NN cord-014516-r59usk02 482 9 and and CC cord-014516-r59usk02 482 10 area area NN cord-014516-r59usk02 482 11 measurement measurement NN cord-014516-r59usk02 482 12 ( ( -LRB- cord-014516-r59usk02 482 13 Ao Ao NNP cord-014516-r59usk02 482 14 MAX MAX NNP cord-014516-r59usk02 482 15 , , , cord-014516-r59usk02 483 1 Ao Ao NNP cord-014516-r59usk02 483 2 P P NNP cord-014516-r59usk02 483 3 , , , cord-014516-r59usk02 483 4 Ao Ao NNP cord-014516-r59usk02 483 5 MIN MIN NNP cord-014516-r59usk02 483 6 ) ) -RRB- cord-014516-r59usk02 483 7 were be VBD cord-014516-r59usk02 483 8 obtained obtain VBN cord-014516-r59usk02 483 9 in in IN cord-014516-r59usk02 483 10 each each DT cord-014516-r59usk02 483 11 patient patient NN cord-014516-r59usk02 483 12 and and CC cord-014516-r59usk02 483 13 averaged average VBD cord-014516-r59usk02 483 14 for for IN cord-014516-r59usk02 483 15 analysis analysis NN cord-014516-r59usk02 483 16 . . . cord-014516-r59usk02 484 1 Only only RB cord-014516-r59usk02 484 2 patients patient NNS cord-014516-r59usk02 484 3 with with IN cord-014516-r59usk02 484 4 aortic aortic JJ cord-014516-r59usk02 484 5 valve valve NN cord-014516-r59usk02 484 6 disease disease NN cord-014516-r59usk02 484 7 and and CC cord-014516-r59usk02 484 8 those those DT cord-014516-r59usk02 484 9 with with IN cord-014516-r59usk02 484 10 atrial atrial JJ cord-014516-r59usk02 484 11 fibrillation fibrillation NN cord-014516-r59usk02 484 12 were be VBD cord-014516-r59usk02 484 13 excluded exclude VBN cord-014516-r59usk02 484 14 from from IN cord-014516-r59usk02 484 15 analysis analysis NN cord-014516-r59usk02 484 16 . . . cord-014516-r59usk02 485 1 Beat beat VB cord-014516-r59usk02 485 2 - - HYPH cord-014516-r59usk02 485 3 to to IN cord-014516-r59usk02 485 4 - - HYPH cord-014516-r59usk02 485 5 beat beat NN cord-014516-r59usk02 485 6 variability variability NN cord-014516-r59usk02 485 7 of of IN cord-014516-r59usk02 485 8 the the DT cord-014516-r59usk02 485 9 Ao Ao NNP cord-014516-r59usk02 485 10 measurements measurement NNS cord-014516-r59usk02 485 11 was be VBD cord-014516-r59usk02 485 12 determined determine VBN cord-014516-r59usk02 485 13 . . . cord-014516-r59usk02 486 1 Standard standard JJ cord-014516-r59usk02 486 2 and and CC cord-014516-r59usk02 486 3 normalized normalized JJ cord-014516-r59usk02 486 4 limits limit NNS cord-014516-r59usk02 486 5 of of IN cord-014516-r59usk02 486 6 agreement agreement NN cord-014516-r59usk02 486 7 ( ( -LRB- cord-014516-r59usk02 486 8 LoA LoA NNP cord-014516-r59usk02 486 9 ) ) -RRB- cord-014516-r59usk02 486 10 plots plot NNS cord-014516-r59usk02 486 11 were be VBD cord-014516-r59usk02 486 12 generated generate VBN cord-014516-r59usk02 486 13 for for IN cord-014516-r59usk02 486 14 each each DT cord-014516-r59usk02 486 15 pairwise pairwise JJ cord-014516-r59usk02 486 16 comparison comparison NN cord-014516-r59usk02 486 17 . . . cord-014516-r59usk02 487 1 The the DT cord-014516-r59usk02 487 2 frequency frequency NN cord-014516-r59usk02 487 3 of of IN cord-014516-r59usk02 487 4 each each DT cord-014516-r59usk02 487 5 Ao Ao NNP cord-014516-r59usk02 487 6 measurement measurement NN cord-014516-r59usk02 487 7 being be VBG cord-014516-r59usk02 487 8 the the DT cord-014516-r59usk02 487 9 largest large JJS cord-014516-r59usk02 487 10 or or CC cord-014516-r59usk02 487 11 smallest small JJS cord-014516-r59usk02 487 12 within within IN cord-014516-r59usk02 487 13 - - HYPH cord-014516-r59usk02 487 14 patient patient NN cord-014516-r59usk02 487 15 measurement measurement NN cord-014516-r59usk02 487 16 was be VBD cord-014516-r59usk02 487 17 determined determine VBN cord-014516-r59usk02 487 18 , , , cord-014516-r59usk02 487 19 and and CC cord-014516-r59usk02 487 20 compared compare VBN cord-014516-r59usk02 487 21 via via IN cord-014516-r59usk02 487 22 repeated repeat VBN cord-014516-r59usk02 487 23 measures measure NNS cord-014516-r59usk02 487 24 ANOVA anova NN cord-014516-r59usk02 487 25 . . . cord-014516-r59usk02 488 1 All all DT cord-014516-r59usk02 488 2 pairwise pairwise JJ cord-014516-r59usk02 488 3 agreement agreement NN cord-014516-r59usk02 488 4 plots plot NNS cord-014516-r59usk02 488 5 of of IN cord-014516-r59usk02 488 6 both both DT cord-014516-r59usk02 488 7 AoD AoD NNP cord-014516-r59usk02 488 8 and and CC cord-014516-r59usk02 488 9 AoA AoA NNP cord-014516-r59usk02 488 10 demonstrated demonstrate VBD cord-014516-r59usk02 488 11 heteroscedasticity heteroscedasticity NN cord-014516-r59usk02 488 12 ; ; , cord-014516-r59usk02 488 13 normalized normalize VBN cord-014516-r59usk02 488 14 AoD aod NN cord-014516-r59usk02 488 15 plots plot NNS cord-014516-r59usk02 488 16 showed show VBD cord-014516-r59usk02 488 17 95 95 CD cord-014516-r59usk02 488 18 % % NN cord-014516-r59usk02 488 19 LoA loa NN cord-014516-r59usk02 488 20 to to TO cord-014516-r59usk02 488 21 be be VB cord-014516-r59usk02 488 22 15 15 CD cord-014516-r59usk02 488 23 % % NN cord-014516-r59usk02 488 24 of of IN cord-014516-r59usk02 488 25 the the DT cord-014516-r59usk02 488 26 mean mean JJ cord-014516-r59usk02 488 27 AoD AoD NNP cord-014516-r59usk02 488 28 measurement measurement NN cord-014516-r59usk02 488 29 , , , cord-014516-r59usk02 488 30 with with IN cord-014516-r59usk02 488 31 a a DT cord-014516-r59usk02 488 32 bias bias NN cord-014516-r59usk02 488 33 of of IN cord-014516-r59usk02 488 34 approximately approximately RB cord-014516-r59usk02 488 35 6.5 6.5 CD cord-014516-r59usk02 488 36 % % NN cord-014516-r59usk02 488 37 for for IN cord-014516-r59usk02 488 38 AoD aod NN cord-014516-r59usk02 488 39 MAX MAX NNP cord-014516-r59usk02 488 40 -AoD -AoD HYPH cord-014516-r59usk02 488 41 MIN MIN NNP cord-014516-r59usk02 488 42 , , , cord-014516-r59usk02 488 43 4 4 CD cord-014516-r59usk02 488 44 % % NN cord-014516-r59usk02 488 45 for for IN cord-014516-r59usk02 488 46 AoD aod NN cord-014516-r59usk02 488 47 MAX MAX NNP cord-014516-r59usk02 488 48 -AoD -AoD HYPH cord-014516-r59usk02 488 49 P P NNP cord-014516-r59usk02 488 50 , , , cord-014516-r59usk02 488 51 and and CC cord-014516-r59usk02 488 52 3 3 CD cord-014516-r59usk02 488 53 % % NN cord-014516-r59usk02 488 54 for for IN cord-014516-r59usk02 488 55 AoD aod NN cord-014516-r59usk02 488 56 P p NN cord-014516-r59usk02 488 57 -AoD -AoD HYPH cord-014516-r59usk02 488 58 MIN MIN NNP cord-014516-r59usk02 488 59 . . . cord-014516-r59usk02 489 1 Normalized normalized JJ cord-014516-r59usk02 489 2 AoA AoA NNP cord-014516-r59usk02 489 3 plots plot NNS cord-014516-r59usk02 489 4 showed show VBD cord-014516-r59usk02 489 5 95%LoA 95%loa CD cord-014516-r59usk02 489 6 to to TO cord-014516-r59usk02 489 7 be be VB cord-014516-r59usk02 489 8 20 20 CD cord-014516-r59usk02 489 9 % % NN cord-014516-r59usk02 489 10 of of IN cord-014516-r59usk02 489 11 the the DT cord-014516-r59usk02 489 12 mean mean NNP cord-014516-r59usk02 489 13 AoA AoA NNP cord-014516-r59usk02 489 14 measurement measurement NN cord-014516-r59usk02 489 15 , , , cord-014516-r59usk02 489 16 with with IN cord-014516-r59usk02 489 17 a a DT cord-014516-r59usk02 489 18 bias bias NN cord-014516-r59usk02 489 19 of of IN cord-014516-r59usk02 489 20 approximately approximately RB cord-014516-r59usk02 489 21 12 12 CD cord-014516-r59usk02 489 22 % % NN cord-014516-r59usk02 489 23 for for IN cord-014516-r59usk02 489 24 AoA AoA NNP cord-014516-r59usk02 489 25 MAX MAX NNP cord-014516-r59usk02 489 26 -AoA -AoA -RRB- cord-014516-r59usk02 489 27 MIN MIN NNP cord-014516-r59usk02 489 28 , , , cord-014516-r59usk02 489 29 5 5 CD cord-014516-r59usk02 489 30 % % NN cord-014516-r59usk02 489 31 for for IN cord-014516-r59usk02 489 32 AoA AoA NNP cord-014516-r59usk02 489 33 MAX MAX NNP cord-014516-r59usk02 489 34 -AoA -AoA -RRB- cord-014516-r59usk02 489 35 P p NN cord-014516-r59usk02 489 36 , , , cord-014516-r59usk02 489 37 and and CC cord-014516-r59usk02 489 38 7 7 CD cord-014516-r59usk02 489 39 % % NN cord-014516-r59usk02 489 40 for for IN cord-014516-r59usk02 489 41 AoA AoA NNP cord-014516-r59usk02 489 42 P P NNP cord-014516-r59usk02 489 43 -AoA -AoA -RRB- cord-014516-r59usk02 489 44 MIN min NN cord-014516-r59usk02 489 45 . . . cord-014516-r59usk02 490 1 AoD AoD NNP cord-014516-r59usk02 490 2 MAX MAX NNP cord-014516-r59usk02 490 3 was be VBD cord-014516-r59usk02 490 4 the the DT cord-014516-r59usk02 490 5 largest large JJS cord-014516-r59usk02 490 6 measurement measurement NN cord-014516-r59usk02 490 7 in in IN cord-014516-r59usk02 490 8 93/131 93/131 CD cord-014516-r59usk02 490 9 ( ( -LRB- cord-014516-r59usk02 490 10 71 71 CD cord-014516-r59usk02 490 11 % % NN cord-014516-r59usk02 490 12 ) ) -RRB- cord-014516-r59usk02 490 13 patients patient NNS cord-014516-r59usk02 490 14 and and CC cord-014516-r59usk02 490 15 AoD AoD NNP cord-014516-r59usk02 490 16 MIN MIN NNP cord-014516-r59usk02 490 17 was be VBD cord-014516-r59usk02 490 18 the the DT cord-014516-r59usk02 490 19 smallest small JJS cord-014516-r59usk02 490 20 measurement measurement NN cord-014516-r59usk02 490 21 in in IN cord-014516-r59usk02 490 22 90/131(69 90/131(69 CD cord-014516-r59usk02 490 23 % % NN cord-014516-r59usk02 490 24 ) ) -RRB- cord-014516-r59usk02 490 25 patients patient NNS cord-014516-r59usk02 490 26 ; ; : cord-014516-r59usk02 490 27 AoA AoA NNP cord-014516-r59usk02 490 28 MAX MAX NNP cord-014516-r59usk02 490 29 was be VBD cord-014516-r59usk02 490 30 the the DT cord-014516-r59usk02 490 31 largest large JJS cord-014516-r59usk02 490 32 measurement measurement NN cord-014516-r59usk02 490 33 in in IN cord-014516-r59usk02 490 34 96/131 96/131 CD cord-014516-r59usk02 490 35 ( ( -LRB- cord-014516-r59usk02 490 36 73 73 CD cord-014516-r59usk02 490 37 % % NN cord-014516-r59usk02 490 38 ) ) -RRB- cord-014516-r59usk02 490 39 patients patient NNS cord-014516-r59usk02 490 40 and and CC cord-014516-r59usk02 490 41 AoA AoA NNP cord-014516-r59usk02 490 42 MIN MIN NNP cord-014516-r59usk02 490 43 was be VBD cord-014516-r59usk02 490 44 the the DT cord-014516-r59usk02 490 45 smallest small JJS cord-014516-r59usk02 490 46 measurement measurement NN cord-014516-r59usk02 490 47 in in IN cord-014516-r59usk02 490 48 95/131 95/131 CD cord-014516-r59usk02 490 49 ( ( -LRB- cord-014516-r59usk02 490 50 73 73 CD cord-014516-r59usk02 490 51 % % NN cord-014516-r59usk02 490 52 ) ) -RRB- cord-014516-r59usk02 490 53 patients patient NNS cord-014516-r59usk02 490 54 . . . cord-014516-r59usk02 491 1 RMANOVA RMANOVA NNP cord-014516-r59usk02 491 2 confirmed confirm VBD cord-014516-r59usk02 491 3 that that IN cord-014516-r59usk02 491 4 Ao Ao NNP cord-014516-r59usk02 491 5 MAX MAX NNP cord-014516-r59usk02 492 1 > > XX cord-014516-r59usk02 493 1 Ao Ao NNP cord-014516-r59usk02 493 2 P p NN cord-014516-r59usk02 494 1 > > XX cord-014516-r59usk02 495 1 Ao Ao NNP cord-014516-r59usk02 495 2 MIN MIN NNP cord-014516-r59usk02 496 1 ( ( -LRB- cord-014516-r59usk02 496 2 p p NN cord-014516-r59usk02 496 3 < < XX cord-014516-r59usk02 496 4 0.0001 0.0001 CD cord-014516-r59usk02 496 5 ) ) -RRB- cord-014516-r59usk02 496 6 . . . cord-014516-r59usk02 497 1 Median median JJ cord-014516-r59usk02 497 2 within within IN cord-014516-r59usk02 497 3 - - HYPH cord-014516-r59usk02 497 4 patient patient NN cord-014516-r59usk02 497 5 within within IN cord-014516-r59usk02 497 6 - - HYPH cord-014516-r59usk02 497 7 measurement measurement NN cord-014516-r59usk02 497 8 variability variability NN cord-014516-r59usk02 497 9 was be VBD cord-014516-r59usk02 497 10 5 5 CD cord-014516-r59usk02 497 11 % % NN cord-014516-r59usk02 497 12 for for IN cord-014516-r59usk02 497 13 AoD aod NN cord-014516-r59usk02 497 14 and and CC cord-014516-r59usk02 497 15 9 9 CD cord-014516-r59usk02 497 16 % % NN cord-014516-r59usk02 497 17 for for IN cord-014516-r59usk02 497 18 AoA AoA NNP cord-014516-r59usk02 497 19 measurements measurement NNS cord-014516-r59usk02 497 20 . . . cord-014516-r59usk02 498 1 Our -PRON- PRP$ cord-014516-r59usk02 498 2 data datum NNS cord-014516-r59usk02 498 3 suggest suggest VBP cord-014516-r59usk02 498 4 that that IN cord-014516-r59usk02 498 5 Ao Ao NNP cord-014516-r59usk02 498 6 measurements measurement NNS cord-014516-r59usk02 498 7 differ differ VBP cord-014516-r59usk02 498 8 throughout throughout IN cord-014516-r59usk02 498 9 diastole diastole NN cord-014516-r59usk02 498 10 , , , cord-014516-r59usk02 498 11 with with IN cord-014516-r59usk02 498 12 Ao Ao NNP cord-014516-r59usk02 498 13 MAX MAX NNP cord-014516-r59usk02 498 14 > > XX cord-014516-r59usk02 499 1 Ao Ao NNP cord-014516-r59usk02 499 2 P p NN cord-014516-r59usk02 500 1 > > XX cord-014516-r59usk02 501 1 Ao Ao NNP cord-014516-r59usk02 501 2 MIN MIN NNP cord-014516-r59usk02 501 3 . . . cord-014516-r59usk02 502 1 The the DT cord-014516-r59usk02 502 2 disparity disparity NN cord-014516-r59usk02 502 3 is be VBZ cord-014516-r59usk02 502 4 greater great JJR cord-014516-r59usk02 502 5 for for IN cord-014516-r59usk02 502 6 area area NN cord-014516-r59usk02 502 7 than than IN cord-014516-r59usk02 502 8 linear linear JJ cord-014516-r59usk02 502 9 estimates estimate NNS cord-014516-r59usk02 502 10 . . . cord-014516-r59usk02 503 1 The the DT cord-014516-r59usk02 503 2 degree degree NN cord-014516-r59usk02 503 3 of of IN cord-014516-r59usk02 503 4 disagreement disagreement NN cord-014516-r59usk02 503 5 between between IN cord-014516-r59usk02 503 6 Ao Ao NNP cord-014516-r59usk02 503 7 MAX MAX NNP cord-014516-r59usk02 503 8 and and CC cord-014516-r59usk02 503 9 Ao Ao NNP cord-014516-r59usk02 503 10 P P NNP cord-014516-r59usk02 503 11 is be VBZ cord-014516-r59usk02 503 12 small small JJ cord-014516-r59usk02 503 13 and and CC cord-014516-r59usk02 503 14 similar similar JJ cord-014516-r59usk02 503 15 to to IN cord-014516-r59usk02 503 16 the the DT cord-014516-r59usk02 503 17 within within IN cord-014516-r59usk02 503 18 - - HYPH cord-014516-r59usk02 503 19 measurement measurement NN cord-014516-r59usk02 503 20 variability variability NN cord-014516-r59usk02 503 21 . . . cord-014516-r59usk02 504 1 Thus thus RB cord-014516-r59usk02 504 2 , , , cord-014516-r59usk02 504 3 using use VBG cord-014516-r59usk02 504 4 either either CC cord-014516-r59usk02 504 5 Ao Ao NNP cord-014516-r59usk02 504 6 MAX MAX NNP cord-014516-r59usk02 504 7 or or CC cord-014516-r59usk02 504 8 Ao Ao NNP cord-014516-r59usk02 504 9 P p NN cord-014516-r59usk02 504 10 measurements measurement NNS cord-014516-r59usk02 504 11 should should MD cord-014516-r59usk02 504 12 result result VB cord-014516-r59usk02 504 13 in in IN cord-014516-r59usk02 504 14 similar similar JJ cord-014516-r59usk02 504 15 ratiometric ratiometric JJ cord-014516-r59usk02 504 16 estimates estimate NNS cord-014516-r59usk02 504 17 of of IN cord-014516-r59usk02 504 18 cardiac cardiac JJ cord-014516-r59usk02 504 19 dimensions dimension NNS cord-014516-r59usk02 504 20 . . . cord-014516-r59usk02 505 1 No no DT cord-014516-r59usk02 505 2 conflicts conflict NNS cord-014516-r59usk02 505 3 of of IN cord-014516-r59usk02 505 4 interest interest NN cord-014516-r59usk02 505 5 reported report VBN cord-014516-r59usk02 505 6 . . . cord-014516-r59usk02 506 1 Feline feline JJ cord-014516-r59usk02 506 2 hypertrophic hypertrophic JJ cord-014516-r59usk02 506 3 cardiomyopathy cardiomyopathy NN cord-014516-r59usk02 506 4 ( ( -LRB- cord-014516-r59usk02 506 5 fHCM fHCM NNP cord-014516-r59usk02 506 6 ) ) -RRB- cord-014516-r59usk02 506 7 is be VBZ cord-014516-r59usk02 506 8 the the DT cord-014516-r59usk02 506 9 most most RBS cord-014516-r59usk02 506 10 common common JJ cord-014516-r59usk02 506 11 heart heart NN cord-014516-r59usk02 506 12 disease disease NN cord-014516-r59usk02 506 13 in in IN cord-014516-r59usk02 506 14 cats cat NNS cord-014516-r59usk02 506 15 . . . cord-014516-r59usk02 507 1 HCM HCM NNP cord-014516-r59usk02 507 2 is be VBZ cord-014516-r59usk02 507 3 considered consider VBN cord-014516-r59usk02 507 4 an an DT cord-014516-r59usk02 507 5 inherited inherit VBN cord-014516-r59usk02 507 6 disease disease NN cord-014516-r59usk02 507 7 of of IN cord-014516-r59usk02 507 8 the the DT cord-014516-r59usk02 507 9 sarcomere sarcomere NN cord-014516-r59usk02 507 10 and and CC cord-014516-r59usk02 507 11 fHCM fhcm NN cord-014516-r59usk02 507 12 has have VBZ cord-014516-r59usk02 507 13 been be VBN cord-014516-r59usk02 507 14 linked link VBN cord-014516-r59usk02 507 15 to to IN cord-014516-r59usk02 507 16 mutations mutation NNS cord-014516-r59usk02 507 17 in in IN cord-014516-r59usk02 507 18 one one CD cord-014516-r59usk02 507 19 sarcomere sarcomere NN cord-014516-r59usk02 507 20 protein protein NN cord-014516-r59usk02 507 21 i.e. i.e. FW cord-014516-r59usk02 507 22 MYBPC3 mybpc3 NN cord-014516-r59usk02 507 23 . . . cord-014516-r59usk02 508 1 However however RB cord-014516-r59usk02 508 2 , , , cord-014516-r59usk02 508 3 the the DT cord-014516-r59usk02 508 4 pathophysiologic pathophysiologic NN cord-014516-r59usk02 508 5 mechanisms mechanism NNS cord-014516-r59usk02 508 6 behind behind IN cord-014516-r59usk02 508 7 disease disease NN cord-014516-r59usk02 508 8 development development NN cord-014516-r59usk02 508 9 and and CC cord-014516-r59usk02 508 10 progression progression NN cord-014516-r59usk02 508 11 are be VBP cord-014516-r59usk02 508 12 largely largely RB cord-014516-r59usk02 508 13 unknown unknown JJ cord-014516-r59usk02 508 14 . . . cord-014516-r59usk02 509 1 In in IN cord-014516-r59usk02 509 2 this this DT cord-014516-r59usk02 509 3 study study NN cord-014516-r59usk02 509 4 we -PRON- PRP cord-014516-r59usk02 509 5 investigate investigate VBP cord-014516-r59usk02 509 6 whether whether IN cord-014516-r59usk02 509 7 mitochondrial mitochondrial JJ cord-014516-r59usk02 509 8 morphological morphological JJ cord-014516-r59usk02 509 9 changes change NNS cord-014516-r59usk02 509 10 in in IN cord-014516-r59usk02 509 11 the the DT cord-014516-r59usk02 509 12 myocardium myocardium NN cord-014516-r59usk02 509 13 accompany accompany JJ cord-014516-r59usk02 509 14 mitochondrial mitochondrial JJ cord-014516-r59usk02 509 15 dysfunction dysfunction NN cord-014516-r59usk02 509 16 and and CC cord-014516-r59usk02 509 17 enhanced enhanced JJ cord-014516-r59usk02 509 18 oxidative oxidative JJ cord-014516-r59usk02 509 19 stress stress NN cord-014516-r59usk02 509 20 formation formation NN cord-014516-r59usk02 509 21 that that WDT cord-014516-r59usk02 509 22 we -PRON- PRP cord-014516-r59usk02 509 23 recently recently RB cord-014516-r59usk02 509 24 found find VBD cord-014516-r59usk02 509 25 in in IN cord-014516-r59usk02 509 26 fHCM fHCM NNP cord-014516-r59usk02 509 27 . . . cord-014516-r59usk02 510 1 Myocardial myocardial JJ cord-014516-r59usk02 510 2 tissue tissue NN cord-014516-r59usk02 510 3 from from IN cord-014516-r59usk02 510 4 the the DT cord-014516-r59usk02 510 5 left left JJ cord-014516-r59usk02 510 6 ventricle ventricle NN cord-014516-r59usk02 510 7 ( ( -LRB- cord-014516-r59usk02 510 8 LV LV NNP cord-014516-r59usk02 510 9 ) ) -RRB- cord-014516-r59usk02 510 10 was be VBD cord-014516-r59usk02 510 11 obtained obtain VBN cord-014516-r59usk02 510 12 immediately immediately RB cord-014516-r59usk02 510 13 after after IN cord-014516-r59usk02 510 14 euthanasia euthanasia NN cord-014516-r59usk02 510 15 from from IN cord-014516-r59usk02 510 16 7 7 CD cord-014516-r59usk02 510 17 cats cat NNS cord-014516-r59usk02 510 18 diagnosed diagnose VBN cord-014516-r59usk02 510 19 with with IN cord-014516-r59usk02 510 20 primary primary JJ cord-014516-r59usk02 510 21 HCM HCM NNP cord-014516-r59usk02 510 22 on on IN cord-014516-r59usk02 510 23 echocardiography echocardiography NN cord-014516-r59usk02 510 24 ( ( -LRB- cord-014516-r59usk02 510 25 3 3 CD cord-014516-r59usk02 510 26 Maine Maine NNP cord-014516-r59usk02 510 27 Coon Coon NNP cord-014516-r59usk02 510 28 , , , cord-014516-r59usk02 510 29 2 2 CD cord-014516-r59usk02 510 30 British British NNP cord-014516-r59usk02 510 31 Shorthair Shorthair NNP cord-014516-r59usk02 510 32 , , , cord-014516-r59usk02 510 33 1 1 CD cord-014516-r59usk02 510 34 Exotic Exotic NNP cord-014516-r59usk02 510 35 Shorthair Shorthair NNP cord-014516-r59usk02 510 36 , , , cord-014516-r59usk02 510 37 1 1 CD cord-014516-r59usk02 510 38 Norwegian Norwegian NNP cord-014516-r59usk02 510 39 Forest Forest NNP cord-014516-r59usk02 510 40 cat cat NN cord-014516-r59usk02 510 41 ) ) -RRB- cord-014516-r59usk02 510 42 and and CC cord-014516-r59usk02 510 43 8 8 CD cord-014516-r59usk02 510 44 age age NN cord-014516-r59usk02 510 45 - - HYPH cord-014516-r59usk02 510 46 matched match VBN cord-014516-r59usk02 510 47 control control NN cord-014516-r59usk02 510 48 cats cat NNS cord-014516-r59usk02 510 49 ( ( -LRB- cord-014516-r59usk02 510 50 5 5 CD cord-014516-r59usk02 510 51 Maine Maine NNP cord-014516-r59usk02 510 52 Coon Coon NNP cord-014516-r59usk02 510 53 , , , cord-014516-r59usk02 510 54 3 3 CD cord-014516-r59usk02 510 55 Norwegian Norwegian NNP cord-014516-r59usk02 510 56 Forest Forest NNP cord-014516-r59usk02 510 57 cats cat NNS cord-014516-r59usk02 510 58 ) ) -RRB- cord-014516-r59usk02 510 59 . . . cord-014516-r59usk02 511 1 Ultrastructural ultrastructural JJ cord-014516-r59usk02 511 2 examination examination NN cord-014516-r59usk02 511 3 was be VBD cord-014516-r59usk02 511 4 performed perform VBN cord-014516-r59usk02 511 5 by by IN cord-014516-r59usk02 511 6 the the DT cord-014516-r59usk02 511 7 use use NN cord-014516-r59usk02 511 8 of of IN cord-014516-r59usk02 511 9 transmission transmission NN cord-014516-r59usk02 511 10 electron electron NN cord-014516-r59usk02 511 11 microscopy microscopy NN cord-014516-r59usk02 511 12 . . . cord-014516-r59usk02 512 1 In in IN cord-014516-r59usk02 512 2 HCM HCM NNP cord-014516-r59usk02 512 3 cats cat NNS cord-014516-r59usk02 512 4 , , , cord-014516-r59usk02 512 5 marked mark VBD cord-014516-r59usk02 512 6 ultrastructural ultrastructural JJ cord-014516-r59usk02 512 7 changes change NNS cord-014516-r59usk02 512 8 of of IN cord-014516-r59usk02 512 9 the the DT cord-014516-r59usk02 512 10 cardiomyocytes cardiomyocyte NNS cord-014516-r59usk02 512 11 were be VBD cord-014516-r59usk02 512 12 observed observe VBN cord-014516-r59usk02 512 13 . . . cord-014516-r59usk02 513 1 The the DT cord-014516-r59usk02 513 2 population population NN cord-014516-r59usk02 513 3 of of IN cord-014516-r59usk02 513 4 subsarcolemmal subsarcolemmal JJ cord-014516-r59usk02 513 5 mitochondria mitochondrion NNS cord-014516-r59usk02 513 6 ( ( -LRB- cord-014516-r59usk02 513 7 SSM SSM NNP cord-014516-r59usk02 513 8 ) ) -RRB- cord-014516-r59usk02 513 9 was be VBD cord-014516-r59usk02 513 10 absent absent JJ cord-014516-r59usk02 513 11 in in IN cord-014516-r59usk02 513 12 large large JJ cord-014516-r59usk02 513 13 cellular cellular JJ cord-014516-r59usk02 513 14 areas area NNS cord-014516-r59usk02 513 15 in in IN cord-014516-r59usk02 513 16 cats cat NNS cord-014516-r59usk02 513 17 with with IN cord-014516-r59usk02 513 18 moderate moderate JJ cord-014516-r59usk02 513 19 and and CC cord-014516-r59usk02 513 20 severe severe JJ cord-014516-r59usk02 513 21 LV LV NNP cord-014516-r59usk02 513 22 hypertrophy hypertrophy NN cord-014516-r59usk02 513 23 . . . cord-014516-r59usk02 514 1 Flattening flatten VBG cord-014516-r59usk02 514 2 of of IN cord-014516-r59usk02 514 3 the the DT cord-014516-r59usk02 514 4 sarcolemma sarcolemma NN cord-014516-r59usk02 514 5 was be VBD cord-014516-r59usk02 514 6 a a DT cord-014516-r59usk02 514 7 common common JJ cord-014516-r59usk02 514 8 finding finding NN cord-014516-r59usk02 514 9 , , , cord-014516-r59usk02 514 10 causing cause VBG cord-014516-r59usk02 514 11 disorganization disorganization NN cord-014516-r59usk02 514 12 of of IN cord-014516-r59usk02 514 13 the the DT cord-014516-r59usk02 514 14 T T NNP cord-014516-r59usk02 514 15 - - HYPH cord-014516-r59usk02 514 16 tubular tubular JJ cord-014516-r59usk02 514 17 system system NN cord-014516-r59usk02 514 18 . . . cord-014516-r59usk02 515 1 Interfibrillar Interfibrillar NNP cord-014516-r59usk02 515 2 mitochondria mitochondrion NNS cord-014516-r59usk02 515 3 ( ( -LRB- cord-014516-r59usk02 515 4 IFM IFM NNP cord-014516-r59usk02 515 5 ) ) -RRB- cord-014516-r59usk02 515 6 were be VBD cord-014516-r59usk02 515 7 disorganized disorganized JJ cord-014516-r59usk02 515 8 but but CC cord-014516-r59usk02 515 9 not not RB cord-014516-r59usk02 515 10 depleted deplete VBN cord-014516-r59usk02 515 11 . . . cord-014516-r59usk02 516 1 Additional additional JJ cord-014516-r59usk02 516 2 changes change NNS cord-014516-r59usk02 516 3 in in IN cord-014516-r59usk02 516 4 cardiomyocytes cardiomyocyte NNS cord-014516-r59usk02 516 5 from from IN cord-014516-r59usk02 516 6 cats cat NNS cord-014516-r59usk02 516 7 diagnosed diagnose VBN cord-014516-r59usk02 516 8 with with IN cord-014516-r59usk02 516 9 fHCM fhcm JJ cord-014516-r59usk02 516 10 included include VBN cord-014516-r59usk02 516 11 remodeling remodeling NN cord-014516-r59usk02 516 12 of of IN cord-014516-r59usk02 516 13 sarcomeres sarcomere NNS cord-014516-r59usk02 516 14 , , , cord-014516-r59usk02 516 15 disorganization disorganization NN cord-014516-r59usk02 516 16 of of IN cord-014516-r59usk02 516 17 myofibrils myofibril NNS cord-014516-r59usk02 516 18 , , , cord-014516-r59usk02 516 19 convolution convolution NN cord-014516-r59usk02 516 20 of of IN cord-014516-r59usk02 516 21 gap gap NN cord-014516-r59usk02 516 22 junctions junction NNS cord-014516-r59usk02 516 23 , , , cord-014516-r59usk02 516 24 accumulation accumulation NN cord-014516-r59usk02 516 25 of of IN cord-014516-r59usk02 516 26 intracellular intracellular JJ cord-014516-r59usk02 516 27 Z z NN cord-014516-r59usk02 516 28 - - HYPH cord-014516-r59usk02 516 29 disc disc NN cord-014516-r59usk02 516 30 material material NN cord-014516-r59usk02 516 31 , , , cord-014516-r59usk02 516 32 perinuclear perinuclear NNP cord-014516-r59usk02 516 33 lipofuscin lipofuscin NNP cord-014516-r59usk02 516 34 granula granula NNP cord-014516-r59usk02 516 35 and and CC cord-014516-r59usk02 516 36 extensive extensive JJ cord-014516-r59usk02 516 37 extracellular extracellular JJ cord-014516-r59usk02 516 38 deposits deposit NNS cord-014516-r59usk02 516 39 of of IN cord-014516-r59usk02 516 40 collagen collagen NN cord-014516-r59usk02 516 41 . . . cord-014516-r59usk02 517 1 In in IN cord-014516-r59usk02 517 2 healthy healthy JJ cord-014516-r59usk02 517 3 mammalian mammalian JJ cord-014516-r59usk02 517 4 cardiomyocytes cardiomyocyte NNS cord-014516-r59usk02 517 5 , , , cord-014516-r59usk02 517 6 the the DT cord-014516-r59usk02 517 7 T T NNP cord-014516-r59usk02 517 8 - - HYPH cord-014516-r59usk02 517 9 tubular tubular JJ cord-014516-r59usk02 517 10 system system NN cord-014516-r59usk02 517 11 upholds uphold VBZ cord-014516-r59usk02 517 12 cellular cellular JJ cord-014516-r59usk02 517 13 structure structure NN cord-014516-r59usk02 517 14 , , , cord-014516-r59usk02 517 15 prevents prevent VBZ cord-014516-r59usk02 517 16 mitochondrial mitochondrial JJ cord-014516-r59usk02 517 17 reticulum reticulum NN cord-014516-r59usk02 517 18 formation formation NN cord-014516-r59usk02 517 19 and and CC cord-014516-r59usk02 517 20 provides provide VBZ cord-014516-r59usk02 517 21 calcium calcium NN cord-014516-r59usk02 517 22 , , , cord-014516-r59usk02 517 23 oxygen oxygen NN cord-014516-r59usk02 517 24 and and CC cord-014516-r59usk02 517 25 substrates substrate NNS cord-014516-r59usk02 517 26 , , , cord-014516-r59usk02 517 27 necessary necessary JJ cord-014516-r59usk02 517 28 for for IN cord-014516-r59usk02 517 29 normal normal JJ cord-014516-r59usk02 517 30 functioning function VBG cord-014516-r59usk02 517 31 muscle muscle NN cord-014516-r59usk02 517 32 . . . cord-014516-r59usk02 518 1 Disorganization disorganization NN cord-014516-r59usk02 518 2 of of IN cord-014516-r59usk02 518 3 the the DT cord-014516-r59usk02 518 4 sarcolemma sarcolemma NNP cord-014516-r59usk02 518 5 and and CC cord-014516-r59usk02 518 6 T T NNP cord-014516-r59usk02 518 7 - - HYPH cord-014516-r59usk02 518 8 tubular tubular JJ cord-014516-r59usk02 518 9 system system NN cord-014516-r59usk02 518 10 may may MD cord-014516-r59usk02 518 11 cause cause VB cord-014516-r59usk02 518 12 the the DT cord-014516-r59usk02 518 13 depletion depletion NN cord-014516-r59usk02 518 14 of of IN cord-014516-r59usk02 518 15 SSM SSM NNP cord-014516-r59usk02 518 16 . . . cord-014516-r59usk02 519 1 Possible possible JJ cord-014516-r59usk02 519 2 mechanisms mechanism NNS cord-014516-r59usk02 519 3 are be VBP cord-014516-r59usk02 519 4 atrophy atrophy NN cord-014516-r59usk02 519 5 or or CC cord-014516-r59usk02 519 6 disruption disruption NN cord-014516-r59usk02 519 7 of of IN cord-014516-r59usk02 519 8 the the DT cord-014516-r59usk02 519 9 mitochondria mitochondrion NNS cord-014516-r59usk02 519 10 or or CC cord-014516-r59usk02 519 11 altered alter VBN cord-014516-r59usk02 519 12 fusion fusion NN cord-014516-r59usk02 519 13 - - HYPH cord-014516-r59usk02 519 14 fission fission NN cord-014516-r59usk02 519 15 dynamics dynamic NNS cord-014516-r59usk02 519 16 . . . cord-014516-r59usk02 520 1 Calcium calcium NN cord-014516-r59usk02 520 2 cycling cycling NN cord-014516-r59usk02 520 3 and and CC cord-014516-r59usk02 520 4 substrate substrate NN cord-014516-r59usk02 520 5 supply supply NN cord-014516-r59usk02 520 6 are be VBP cord-014516-r59usk02 520 7 likely likely JJ cord-014516-r59usk02 520 8 to to TO cord-014516-r59usk02 520 9 be be VB cord-014516-r59usk02 520 10 compromised compromise VBN cord-014516-r59usk02 520 11 by by IN cord-014516-r59usk02 520 12 the the DT cord-014516-r59usk02 520 13 observed observed JJ cord-014516-r59usk02 520 14 structural structural JJ cord-014516-r59usk02 520 15 changes change NNS cord-014516-r59usk02 520 16 . . . cord-014516-r59usk02 521 1 We -PRON- PRP cord-014516-r59usk02 521 2 propose propose VBP cord-014516-r59usk02 521 3 this this DT cord-014516-r59usk02 521 4 to to TO cord-014516-r59usk02 521 5 be be VB cord-014516-r59usk02 521 6 related relate VBN cord-014516-r59usk02 521 7 to to IN cord-014516-r59usk02 521 8 mitochondrial mitochondrial JJ cord-014516-r59usk02 521 9 dysfunction dysfunction NN cord-014516-r59usk02 521 10 and and CC cord-014516-r59usk02 521 11 oxidative oxidative JJ cord-014516-r59usk02 521 12 stress stress NN cord-014516-r59usk02 521 13 formation formation NN cord-014516-r59usk02 521 14 that that WDT cord-014516-r59usk02 521 15 occurs occur VBZ cord-014516-r59usk02 521 16 in in IN cord-014516-r59usk02 521 17 fHCM fhcm NN cord-014516-r59usk02 521 18 , , , cord-014516-r59usk02 521 19 however however RB cord-014516-r59usk02 521 20 a a DT cord-014516-r59usk02 521 21 causative causative JJ cord-014516-r59usk02 521 22 relationship relationship NN cord-014516-r59usk02 521 23 remains remain VBZ cord-014516-r59usk02 521 24 unknown unknown JJ cord-014516-r59usk02 521 25 . . . cord-014516-r59usk02 522 1 In in IN cord-014516-r59usk02 522 2 conclusion conclusion NN cord-014516-r59usk02 522 3 , , , cord-014516-r59usk02 522 4 morphological morphological JJ cord-014516-r59usk02 522 5 changes change NNS cord-014516-r59usk02 522 6 of of IN cord-014516-r59usk02 522 7 mitochondria mitochondrion NNS cord-014516-r59usk02 522 8 and and CC cord-014516-r59usk02 522 9 extra extra JJ cord-014516-r59usk02 522 10 - - JJ cord-014516-r59usk02 522 11 sarcomeric sarcomeric JJ cord-014516-r59usk02 522 12 structures structure NNS cord-014516-r59usk02 522 13 are be VBP cord-014516-r59usk02 522 14 common common JJ cord-014516-r59usk02 522 15 in in IN cord-014516-r59usk02 522 16 fHCM fhcm NN cord-014516-r59usk02 522 17 , , , cord-014516-r59usk02 522 18 regardless regardless RB cord-014516-r59usk02 522 19 of of IN cord-014516-r59usk02 522 20 breed breed NN cord-014516-r59usk02 522 21 , , , cord-014516-r59usk02 522 22 genotype genotype NN cord-014516-r59usk02 522 23 and and CC cord-014516-r59usk02 522 24 phenotypic phenotypic JJ cord-014516-r59usk02 522 25 disease disease NN cord-014516-r59usk02 522 26 expression expression NN cord-014516-r59usk02 522 27 . . . cord-014516-r59usk02 523 1 Moreover moreover RB cord-014516-r59usk02 523 2 , , , cord-014516-r59usk02 523 3 mitochondrial mitochondrial JJ cord-014516-r59usk02 523 4 subpopulation subpopulation NN cord-014516-r59usk02 523 5 - - HYPH cord-014516-r59usk02 523 6 specific specific JJ cord-014516-r59usk02 523 7 changes change NNS cord-014516-r59usk02 523 8 occur occur VBP cord-014516-r59usk02 523 9 in in IN cord-014516-r59usk02 523 10 fHCM fhcm NN cord-014516-r59usk02 523 11 with with IN cord-014516-r59usk02 523 12 depletion depletion NN cord-014516-r59usk02 523 13 of of IN cord-014516-r59usk02 523 14 SSM SSM NNP cord-014516-r59usk02 523 15 . . . cord-014516-r59usk02 524 1 Ultrastructural ultrastructural JJ cord-014516-r59usk02 524 2 and and CC cord-014516-r59usk02 524 3 functional functional JJ cord-014516-r59usk02 524 4 changes change NNS cord-014516-r59usk02 524 5 of of IN cord-014516-r59usk02 524 6 cardiac cardiac JJ cord-014516-r59usk02 524 7 muscle muscle NN cord-014516-r59usk02 524 8 mitochondria mitochondrion NNS cord-014516-r59usk02 524 9 are be VBP cord-014516-r59usk02 524 10 considered consider VBN cord-014516-r59usk02 524 11 important important JJ cord-014516-r59usk02 524 12 molecular molecular JJ cord-014516-r59usk02 524 13 mechanisms mechanism NNS cord-014516-r59usk02 524 14 , , , cord-014516-r59usk02 524 15 responsible responsible JJ cord-014516-r59usk02 524 16 for for IN cord-014516-r59usk02 524 17 the the DT cord-014516-r59usk02 524 18 development development NN cord-014516-r59usk02 524 19 and and CC cord-014516-r59usk02 524 20 progression progression NN cord-014516-r59usk02 524 21 of of IN cord-014516-r59usk02 524 22 fHCM fhcm NN cord-014516-r59usk02 524 23 and and CC cord-014516-r59usk02 524 24 may may MD cord-014516-r59usk02 524 25 be be VB cord-014516-r59usk02 524 26 relevant relevant JJ cord-014516-r59usk02 524 27 future future JJ cord-014516-r59usk02 524 28 treatment treatment NN cord-014516-r59usk02 524 29 targets target NNS cord-014516-r59usk02 524 30 . . . cord-014516-r59usk02 525 1 No no DT cord-014516-r59usk02 525 2 conflicts conflict NNS cord-014516-r59usk02 525 3 of of IN cord-014516-r59usk02 525 4 interest interest NN cord-014516-r59usk02 525 5 reported report VBN cord-014516-r59usk02 525 6 . . . cord-014516-r59usk02 526 1 Patent patent NN cord-014516-r59usk02 526 2 ductus ductus NN cord-014516-r59usk02 526 3 arteriosus arteriosus NN cord-014516-r59usk02 526 4 ( ( -LRB- cord-014516-r59usk02 526 5 PDA PDA NNP cord-014516-r59usk02 526 6 ) ) -RRB- cord-014516-r59usk02 526 7 is be VBZ cord-014516-r59usk02 526 8 one one CD cord-014516-r59usk02 526 9 of of IN cord-014516-r59usk02 526 10 the the DT cord-014516-r59usk02 526 11 most most RBS cord-014516-r59usk02 526 12 common common JJ cord-014516-r59usk02 526 13 congenital congenital JJ cord-014516-r59usk02 526 14 cardiac cardiac JJ cord-014516-r59usk02 526 15 defect defect NN cord-014516-r59usk02 526 16 in in IN cord-014516-r59usk02 526 17 the the DT cord-014516-r59usk02 526 18 dog dog NN cord-014516-r59usk02 526 19 . . . cord-014516-r59usk02 527 1 Ductal Ductal NNP cord-014516-r59usk02 527 2 patency patency NN cord-014516-r59usk02 527 3 is be VBZ cord-014516-r59usk02 527 4 associated associate VBN cord-014516-r59usk02 527 5 with with IN cord-014516-r59usk02 527 6 pulmonary pulmonary JJ cord-014516-r59usk02 527 7 overcirculation overcirculation NN cord-014516-r59usk02 527 8 , , , cord-014516-r59usk02 527 9 left leave VBD cord-014516-r59usk02 527 10 ventricular ventricular JJ cord-014516-r59usk02 527 11 volume volume NN cord-014516-r59usk02 527 12 overload overload NN cord-014516-r59usk02 527 13 and and CC cord-014516-r59usk02 527 14 can can MD cord-014516-r59usk02 527 15 rapidly rapidly RB cord-014516-r59usk02 527 16 determine determine VB cord-014516-r59usk02 527 17 congestive congestive JJ cord-014516-r59usk02 527 18 heart heart NN cord-014516-r59usk02 527 19 failure failure NN cord-014516-r59usk02 527 20 if if IN cord-014516-r59usk02 527 21 untreated untreated JJ cord-014516-r59usk02 527 22 . . . cord-014516-r59usk02 528 1 Several several JJ cord-014516-r59usk02 528 2 devices device NNS cord-014516-r59usk02 528 3 to to TO cord-014516-r59usk02 528 4 close close VB cord-014516-r59usk02 528 5 the the DT cord-014516-r59usk02 528 6 PDA PDA NNP cord-014516-r59usk02 528 7 have have VBP cord-014516-r59usk02 528 8 been be VBN cord-014516-r59usk02 528 9 used use VBN cord-014516-r59usk02 528 10 , , , cord-014516-r59usk02 528 11 with with IN cord-014516-r59usk02 528 12 Amplatzer Amplatzer NNP cord-014516-r59usk02 528 13 Canine Canine NNP cord-014516-r59usk02 528 14 Duct duct NN cord-014516-r59usk02 528 15 Occluder Occluder NNP cord-014516-r59usk02 528 16 ( ( -LRB- cord-014516-r59usk02 528 17 ACDO ACDO NNP cord-014516-r59usk02 528 18 © © NNP cord-014516-r59usk02 528 19 ) ) -RRB- cord-014516-r59usk02 528 20 being be VBG cord-014516-r59usk02 528 21 considered consider VBN cord-014516-r59usk02 528 22 the the DT cord-014516-r59usk02 528 23 safer safe JJR cord-014516-r59usk02 528 24 device device NN cord-014516-r59usk02 528 25 with with IN cord-014516-r59usk02 528 26 lowest low JJS cord-014516-r59usk02 528 27 complication complication NN cord-014516-r59usk02 528 28 rates rate NNS cord-014516-r59usk02 528 29 . . . cord-014516-r59usk02 529 1 Echocardiography echocardiography NN cord-014516-r59usk02 529 2 represents represent VBZ cord-014516-r59usk02 529 3 the the DT cord-014516-r59usk02 529 4 cornerstone cornerstone NN cord-014516-r59usk02 529 5 of of IN cord-014516-r59usk02 529 6 PDA PDA NNP cord-014516-r59usk02 529 7 diagnosis diagnosis NN cord-014516-r59usk02 529 8 , , , cord-014516-r59usk02 529 9 but but CC cord-014516-r59usk02 529 10 its -PRON- PRP$ cord-014516-r59usk02 529 11 role role NN cord-014516-r59usk02 529 12 has have VBZ cord-014516-r59usk02 529 13 been be VBN cord-014516-r59usk02 529 14 recently recently RB cord-014516-r59usk02 529 15 expanded expand VBN cord-014516-r59usk02 529 16 to to IN cord-014516-r59usk02 529 17 wider wide JJR cord-014516-r59usk02 529 18 field field NN cord-014516-r59usk02 529 19 of of IN cord-014516-r59usk02 529 20 application application NN cord-014516-r59usk02 529 21 : : : cord-014516-r59usk02 529 22 device device NN cord-014516-r59usk02 529 23 sizing sizing NN cord-014516-r59usk02 529 24 and and CC cord-014516-r59usk02 529 25 intraoperative intraoperative JJ cord-014516-r59usk02 529 26 monitoring monitoring NN cord-014516-r59usk02 529 27 , , , cord-014516-r59usk02 529 28 as as RB cord-014516-r59usk02 529 29 well well RB cord-014516-r59usk02 529 30 as as IN cord-014516-r59usk02 529 31 a a DT cord-014516-r59usk02 529 32 tool tool NN cord-014516-r59usk02 529 33 to to TO cord-014516-r59usk02 529 34 quantify quantify VB cord-014516-r59usk02 529 35 cardiac cardiac JJ cord-014516-r59usk02 529 36 morphology morphology NN cord-014516-r59usk02 529 37 and and CC cord-014516-r59usk02 529 38 function function NN cord-014516-r59usk02 529 39 . . . cord-014516-r59usk02 530 1 Speckletracking Speckletracking NNP cord-014516-r59usk02 530 2 echocardiography echocardiography NN cord-014516-r59usk02 530 3 ( ( -LRB- cord-014516-r59usk02 530 4 STE STE NNP cord-014516-r59usk02 530 5 ) ) -RRB- cord-014516-r59usk02 530 6 has have VBZ cord-014516-r59usk02 530 7 been be VBN cord-014516-r59usk02 530 8 used use VBN cord-014516-r59usk02 530 9 to to TO cord-014516-r59usk02 530 10 evaluate evaluate VB cord-014516-r59usk02 530 11 cardiac cardiac JJ cord-014516-r59usk02 530 12 function function NN cord-014516-r59usk02 530 13 in in IN cord-014516-r59usk02 530 14 a a DT cord-014516-r59usk02 530 15 wide wide JJ cord-014516-r59usk02 530 16 variety variety NN cord-014516-r59usk02 530 17 of of IN cord-014516-r59usk02 530 18 diseases disease NNS cord-014516-r59usk02 530 19 in in IN cord-014516-r59usk02 530 20 human human JJ cord-014516-r59usk02 530 21 and and CC cord-014516-r59usk02 530 22 veterinary veterinary JJ cord-014516-r59usk02 530 23 patients patient NNS cord-014516-r59usk02 530 24 , , , cord-014516-r59usk02 530 25 however however RB cord-014516-r59usk02 530 26 no no DT cord-014516-r59usk02 530 27 study study NN cord-014516-r59usk02 530 28 has have VBZ cord-014516-r59usk02 530 29 evaluated evaluate VBN cord-014516-r59usk02 530 30 its -PRON- PRP$ cord-014516-r59usk02 530 31 usefulness usefulness NN cord-014516-r59usk02 530 32 in in IN cord-014516-r59usk02 530 33 dogs dog NNS cord-014516-r59usk02 530 34 affected affect VBN cord-014516-r59usk02 530 35 by by IN cord-014516-r59usk02 530 36 PDA PDA NNP cord-014516-r59usk02 530 37 both both CC cord-014516-r59usk02 530 38 before before IN cord-014516-r59usk02 530 39 and and CC cord-014516-r59usk02 530 40 after after IN cord-014516-r59usk02 530 41 percutaneous percutaneous JJ cord-014516-r59usk02 530 42 closure closure NN cord-014516-r59usk02 530 43 of of IN cord-014516-r59usk02 530 44 PDA PDA NNP cord-014516-r59usk02 530 45 . . . cord-014516-r59usk02 531 1 The the DT cord-014516-r59usk02 531 2 aim aim NN cord-014516-r59usk02 531 3 of of IN cord-014516-r59usk02 531 4 our -PRON- PRP$ cord-014516-r59usk02 531 5 study study NN cord-014516-r59usk02 531 6 was be VBD cord-014516-r59usk02 531 7 therefore therefore RB cord-014516-r59usk02 531 8 to to TO cord-014516-r59usk02 531 9 assess assess VB cord-014516-r59usk02 531 10 standard standard JJ cord-014516-r59usk02 531 11 M M NNP cord-014516-r59usk02 531 12 / / SYM cord-014516-r59usk02 531 13 Bmode Bmode NNP cord-014516-r59usk02 531 14 derived derive VBD cord-014516-r59usk02 531 15 parameter parameter NN cord-014516-r59usk02 531 16 of of IN cord-014516-r59usk02 531 17 cardiac cardiac JJ cord-014516-r59usk02 531 18 function function NN cord-014516-r59usk02 531 19 and and CC cord-014516-r59usk02 531 20 STE STE NNP cord-014516-r59usk02 531 21 derived derive VBD cord-014516-r59usk02 531 22 longitudinal longitudinal JJ cord-014516-r59usk02 531 23 , , , cord-014516-r59usk02 531 24 radial radial JJ cord-014516-r59usk02 531 25 and and CC cord-014516-r59usk02 531 26 circumferential circumferential JJ cord-014516-r59usk02 531 27 strain strain NN cord-014516-r59usk02 531 28 and and CC cord-014516-r59usk02 531 29 strain strain NN cord-014516-r59usk02 531 30 rate rate NN cord-014516-r59usk02 531 31 before before RB cord-014516-r59usk02 531 32 and and CC cord-014516-r59usk02 531 33 after after IN cord-014516-r59usk02 531 34 PDA pda NN cord-014516-r59usk02 531 35 closure closure NN cord-014516-r59usk02 531 36 . . . cord-014516-r59usk02 532 1 Twenty twenty CD cord-014516-r59usk02 532 2 - - HYPH cord-014516-r59usk02 532 3 five five CD cord-014516-r59usk02 532 4 dogs dog NNS cord-014516-r59usk02 532 5 of of IN cord-014516-r59usk02 532 6 different different JJ cord-014516-r59usk02 532 7 breeds breed NNS cord-014516-r59usk02 532 8 , , , cord-014516-r59usk02 532 9 age age NN cord-014516-r59usk02 532 10 and and CC cord-014516-r59usk02 532 11 weight weight NN cord-014516-r59usk02 532 12 were be VBD cord-014516-r59usk02 532 13 prospectively prospectively RB cord-014516-r59usk02 532 14 recruited recruit VBN cord-014516-r59usk02 532 15 and and CC cord-014516-r59usk02 532 16 a a DT cord-014516-r59usk02 532 17 complete complete JJ cord-014516-r59usk02 532 18 echocardiographic echocardiographic JJ cord-014516-r59usk02 532 19 evaluation evaluation NN cord-014516-r59usk02 532 20 was be VBD cord-014516-r59usk02 532 21 performed perform VBN cord-014516-r59usk02 532 22 before before IN cord-014516-r59usk02 532 23 and and CC cord-014516-r59usk02 532 24 24 24 CD cord-014516-r59usk02 532 25 hours hour NNS cord-014516-r59usk02 532 26 after after IN cord-014516-r59usk02 532 27 PDA pda NN cord-014516-r59usk02 532 28 closure closure NN cord-014516-r59usk02 532 29 . . . cord-014516-r59usk02 533 1 End end VB cord-014516-r59usk02 533 2 diastolic diastolic JJ cord-014516-r59usk02 533 3 and and CC cord-014516-r59usk02 533 4 systolic systolic JJ cord-014516-r59usk02 533 5 diameters diameter NNS cord-014516-r59usk02 533 6 indexed index VBN cord-014516-r59usk02 533 7 for for IN cord-014516-r59usk02 533 8 body body NN cord-014516-r59usk02 533 9 surface surface NN cord-014516-r59usk02 533 10 area area NN cord-014516-r59usk02 533 11 ( ( -LRB- cord-014516-r59usk02 533 12 EDVI EDVI NNP cord-014516-r59usk02 533 13 / / SYM cord-014516-r59usk02 533 14 ESVI ESVI NNP cord-014516-r59usk02 533 15 ) ) -RRB- cord-014516-r59usk02 534 1 both both DT cord-014516-r59usk02 534 2 derived derive VBN cord-014516-r59usk02 534 3 by by IN cord-014516-r59usk02 534 4 M M NNP cord-014516-r59usk02 534 5 - - HYPH cord-014516-r59usk02 534 6 mode mode NN cord-014516-r59usk02 534 7 and and CC cord-014516-r59usk02 534 8 B b NN cord-014516-r59usk02 534 9 - - HYPH cord-014516-r59usk02 534 10 mode mode NN cord-014516-r59usk02 534 11 views view NNS cord-014516-r59usk02 534 12 , , , cord-014516-r59usk02 534 13 allometric allometric JJ cord-014516-r59usk02 534 14 scaling scaling NN cord-014516-r59usk02 534 15 derived derive VBN cord-014516-r59usk02 534 16 AlloD AlloD NNP cord-014516-r59usk02 534 17 and and CC cord-014516-r59usk02 534 18 AlloS AlloS NNP cord-014516-r59usk02 534 19 , , , cord-014516-r59usk02 534 20 Sphericity Sphericity NNP cord-014516-r59usk02 534 21 Index Index NNP cord-014516-r59usk02 534 22 ( ( -LRB- cord-014516-r59usk02 534 23 SI SI NNP cord-014516-r59usk02 534 24 ) ) -RRB- cord-014516-r59usk02 534 25 and and CC cord-014516-r59usk02 534 26 pulmonary pulmonary JJ cord-014516-r59usk02 534 27 to to IN cord-014516-r59usk02 534 28 systemic systemic JJ cord-014516-r59usk02 534 29 flow flow NN cord-014516-r59usk02 534 30 ratio ratio NN cord-014516-r59usk02 534 31 ( ( -LRB- cord-014516-r59usk02 534 32 Qp Qp NNP cord-014516-r59usk02 534 33 / / SYM cord-014516-r59usk02 534 34 Qs Qs NNP cord-014516-r59usk02 534 35 ) ) -RRB- cord-014516-r59usk02 534 36 were be VBD cord-014516-r59usk02 534 37 assessed assess VBN cord-014516-r59usk02 534 38 both both CC cord-014516-r59usk02 534 39 pre pre JJ cord-014516-r59usk02 534 40 and and CC cord-014516-r59usk02 534 41 postoperatively postoperatively RB cord-014516-r59usk02 534 42 . . . cord-014516-r59usk02 535 1 STE STE NNP cord-014516-r59usk02 535 2 derived derive VBD cord-014516-r59usk02 535 3 parameters parameter NNS cord-014516-r59usk02 535 4 assessed assess VBN cord-014516-r59usk02 535 5 were be VBD cord-014516-r59usk02 535 6 longitudinal longitudinal JJ cord-014516-r59usk02 535 7 , , , cord-014516-r59usk02 535 8 radial radial JJ cord-014516-r59usk02 535 9 and and CC cord-014516-r59usk02 535 10 circumferential circumferential JJ cord-014516-r59usk02 535 11 strain strain NN cord-014516-r59usk02 535 12 and and CC cord-014516-r59usk02 535 13 strain strain NN cord-014516-r59usk02 535 14 rate rate NN cord-014516-r59usk02 535 15 . . . cord-014516-r59usk02 536 1 A a DT cord-014516-r59usk02 536 2 statistically statistically RB cord-014516-r59usk02 536 3 significant significant JJ cord-014516-r59usk02 536 4 difference difference NN cord-014516-r59usk02 536 5 was be VBD cord-014516-r59usk02 536 6 found find VBN cord-014516-r59usk02 536 7 in in IN cord-014516-r59usk02 536 8 all all DT cord-014516-r59usk02 536 9 standard standard JJ cord-014516-r59usk02 536 10 parameters parameter NNS cord-014516-r59usk02 536 11 of of IN cord-014516-r59usk02 536 12 cardiac cardiac JJ cord-014516-r59usk02 536 13 function function NN cord-014516-r59usk02 536 14 before before IN cord-014516-r59usk02 536 15 and and CC cord-014516-r59usk02 536 16 after after IN cord-014516-r59usk02 536 17 PDA pda NN cord-014516-r59usk02 536 18 closure closure NN cord-014516-r59usk02 536 19 ( ( -LRB- cord-014516-r59usk02 536 20 p p NN cord-014516-r59usk02 536 21 < < XX cord-014516-r59usk02 536 22 0.002 0.002 CD cord-014516-r59usk02 536 23 ) ) -RRB- cord-014516-r59usk02 536 24 , , , cord-014516-r59usk02 536 25 with with IN cord-014516-r59usk02 536 26 a a DT cord-014516-r59usk02 536 27 general general JJ cord-014516-r59usk02 536 28 decrease decrease NN cord-014516-r59usk02 536 29 in in IN cord-014516-r59usk02 536 30 values value NNS cord-014516-r59usk02 536 31 24 24 CD cord-014516-r59usk02 536 32 hours hour NNS cord-014516-r59usk02 536 33 postoperatively postoperatively RB cord-014516-r59usk02 536 34 . . . cord-014516-r59usk02 537 1 STE STE NNP cord-014516-r59usk02 537 2 derived derive VBD cord-014516-r59usk02 537 3 parameters parameter NNS cord-014516-r59usk02 537 4 of of IN cord-014516-r59usk02 537 5 cardiac cardiac JJ cord-014516-r59usk02 537 6 function function NN cord-014516-r59usk02 537 7 showed show VBD cord-014516-r59usk02 537 8 a a DT cord-014516-r59usk02 537 9 trend trend NN cord-014516-r59usk02 537 10 toward toward IN cord-014516-r59usk02 537 11 a a DT cord-014516-r59usk02 537 12 decrease decrease NN cord-014516-r59usk02 537 13 back back RB cord-014516-r59usk02 537 14 to to IN cord-014516-r59usk02 537 15 normal normal JJ cord-014516-r59usk02 537 16 values value NNS cord-014516-r59usk02 537 17 , , , cord-014516-r59usk02 537 18 which which WDT cord-014516-r59usk02 537 19 was be VBD cord-014516-r59usk02 537 20 statistically statistically RB cord-014516-r59usk02 537 21 significant significant JJ cord-014516-r59usk02 537 22 ( ( -LRB- cord-014516-r59usk02 537 23 p p NN cord-014516-r59usk02 537 24 < < XX cord-014516-r59usk02 537 25 0.01 0.01 CD cord-014516-r59usk02 537 26 ) ) -RRB- cord-014516-r59usk02 537 27 for for IN cord-014516-r59usk02 537 28 circumferential circumferential JJ cord-014516-r59usk02 537 29 and and CC cord-014516-r59usk02 537 30 radial radial JJ cord-014516-r59usk02 537 31 strain strain NN cord-014516-r59usk02 537 32 and and CC cord-014516-r59usk02 537 33 strain strain NN cord-014516-r59usk02 537 34 rate rate NN cord-014516-r59usk02 537 35 , , , cord-014516-r59usk02 537 36 while while IN cord-014516-r59usk02 537 37 longitudinal longitudinal JJ cord-014516-r59usk02 537 38 strain strain NN cord-014516-r59usk02 537 39 and and CC cord-014516-r59usk02 537 40 strain strain NN cord-014516-r59usk02 537 41 rate rate NN cord-014516-r59usk02 537 42 did do VBD cord-014516-r59usk02 537 43 not not RB cord-014516-r59usk02 537 44 reach reach VB cord-014516-r59usk02 537 45 statistically statistically RB cord-014516-r59usk02 537 46 significance significance NN cord-014516-r59usk02 537 47 . . . cord-014516-r59usk02 538 1 Based base VBN cord-014516-r59usk02 538 2 on on IN cord-014516-r59usk02 538 3 our -PRON- PRP$ cord-014516-r59usk02 538 4 results result NNS cord-014516-r59usk02 538 5 , , , cord-014516-r59usk02 538 6 no no DT cord-014516-r59usk02 538 7 cardiac cardiac JJ cord-014516-r59usk02 538 8 dysfunction dysfunction NN cord-014516-r59usk02 538 9 was be VBD cord-014516-r59usk02 538 10 identified identify VBN cord-014516-r59usk02 538 11 by by IN cord-014516-r59usk02 538 12 the the DT cord-014516-r59usk02 538 13 use use NN cord-014516-r59usk02 538 14 of of IN cord-014516-r59usk02 538 15 STE STE NNP cord-014516-r59usk02 538 16 derived derive VBN cord-014516-r59usk02 538 17 parameters parameter NNS cord-014516-r59usk02 538 18 both both CC cord-014516-r59usk02 538 19 before before IN cord-014516-r59usk02 538 20 and and CC cord-014516-r59usk02 538 21 after after IN cord-014516-r59usk02 538 22 PDA pda NN cord-014516-r59usk02 538 23 closure closure NN cord-014516-r59usk02 538 24 , , , cord-014516-r59usk02 538 25 with with IN cord-014516-r59usk02 538 26 an an DT cord-014516-r59usk02 538 27 increased increased JJ cord-014516-r59usk02 538 28 contractility contractility NN cord-014516-r59usk02 538 29 as as IN cord-014516-r59usk02 538 30 identified identify VBN cord-014516-r59usk02 538 31 by by IN cord-014516-r59usk02 538 32 higher high JJR cord-014516-r59usk02 538 33 than than IN cord-014516-r59usk02 538 34 normal normal JJ cord-014516-r59usk02 538 35 STE STE NNP cord-014516-r59usk02 538 36 values value NNS cord-014516-r59usk02 538 37 before before IN cord-014516-r59usk02 538 38 PDA PDA NNP cord-014516-r59usk02 538 39 closure closure NN cord-014516-r59usk02 538 40 and and CC cord-014516-r59usk02 538 41 a a DT cord-014516-r59usk02 538 42 decrease decrease NN cord-014516-r59usk02 538 43 back back RB cord-014516-r59usk02 538 44 to to IN cord-014516-r59usk02 538 45 normal normal JJ cord-014516-r59usk02 538 46 strain strain NN cord-014516-r59usk02 538 47 and and CC cord-014516-r59usk02 538 48 strain strain NN cord-014516-r59usk02 538 49 rate rate NN cord-014516-r59usk02 538 50 values value NNS cord-014516-r59usk02 538 51 for for IN cord-014516-r59usk02 538 52 both both CC cord-014516-r59usk02 538 53 circumferential circumferential JJ cord-014516-r59usk02 538 54 and and CC cord-014516-r59usk02 538 55 radial radial JJ cord-014516-r59usk02 538 56 immediately immediately RB cord-014516-r59usk02 538 57 after after IN cord-014516-r59usk02 538 58 percutaneous percutaneous JJ cord-014516-r59usk02 538 59 closure closure NN cord-014516-r59usk02 538 60 . . . cord-014516-r59usk02 539 1 Longitudinal longitudinal JJ cord-014516-r59usk02 539 2 strain strain NN cord-014516-r59usk02 539 3 persists persist VBZ cord-014516-r59usk02 539 4 on on IN cord-014516-r59usk02 539 5 higher high JJR cord-014516-r59usk02 539 6 than than IN cord-014516-r59usk02 539 7 normal normal JJ cord-014516-r59usk02 539 8 values value NNS cord-014516-r59usk02 539 9 , , , cord-014516-r59usk02 539 10 refusing refuse VBG cord-014516-r59usk02 539 11 the the DT cord-014516-r59usk02 539 12 hypothesis hypothesis NN cord-014516-r59usk02 539 13 of of IN cord-014516-r59usk02 539 14 systolic systolic JJ cord-014516-r59usk02 539 15 dysfunction dysfunction NN cord-014516-r59usk02 539 16 after after IN cord-014516-r59usk02 539 17 PDA PDA NNP cord-014516-r59usk02 539 18 closure closure NN cord-014516-r59usk02 539 19 and and CC cord-014516-r59usk02 539 20 suggesting suggest VBG cord-014516-r59usk02 539 21 a a DT cord-014516-r59usk02 539 22 longer long RBR cord-014516-r59usk02 539 23 reverse reverse JJ cord-014516-r59usk02 539 24 remodeling remodeling NN cord-014516-r59usk02 539 25 process process NN cord-014516-r59usk02 539 26 after after IN cord-014516-r59usk02 539 27 PDA pda NN cord-014516-r59usk02 539 28 closure closure NN cord-014516-r59usk02 539 29 . . . cord-014516-r59usk02 540 1 Dr Dr NNP cord-014516-r59usk02 540 2 Bussadori Bussadori NNP cord-014516-r59usk02 540 3 receives receive VBZ cord-014516-r59usk02 540 4 royalties royalty NNS cord-014516-r59usk02 540 5 from from IN cord-014516-r59usk02 540 6 ESAOTE ESAOTE NNP cord-014516-r59usk02 540 7 ( ( -LRB- cord-014516-r59usk02 540 8 Florence Florence NNP cord-014516-r59usk02 540 9 , , , cord-014516-r59usk02 540 10 italy italy NNP cord-014516-r59usk02 540 11 ) ) -RRB- cord-014516-r59usk02 540 12 related relate VBD cord-014516-r59usk02 540 13 to to IN cord-014516-r59usk02 540 14 an an DT cord-014516-r59usk02 540 15 european european JJ cord-014516-r59usk02 540 16 patent patent NN cord-014516-r59usk02 540 17 ( ( -LRB- cord-014516-r59usk02 540 18 nr nr NNP cord-014516-r59usk02 540 19 071129712 071129712 CD cord-014516-r59usk02 540 20 ) ) -RRB- cord-014516-r59usk02 541 1 he -PRON- PRP cord-014516-r59usk02 541 2 developed develop VBD cord-014516-r59usk02 541 3 for for IN cord-014516-r59usk02 541 4 Xstrain Xstrain NNP cord-014516-r59usk02 541 5 software software NN cord-014516-r59usk02 541 6 . . . cord-014516-r59usk02 542 1 The the DT cord-014516-r59usk02 542 2 study study NN cord-014516-r59usk02 542 3 was be VBD cord-014516-r59usk02 542 4 not not RB cord-014516-r59usk02 542 5 funded fund VBN cord-014516-r59usk02 542 6 by by IN cord-014516-r59usk02 542 7 a a DT cord-014516-r59usk02 542 8 research research NN cord-014516-r59usk02 542 9 grant grant NN cord-014516-r59usk02 542 10 . . . cord-014516-r59usk02 543 1 Cardiac cardiac JJ cord-014516-r59usk02 543 2 cachexia cachexia NN cord-014516-r59usk02 543 3 which which WDT cord-014516-r59usk02 543 4 is be VBZ cord-014516-r59usk02 543 5 characterized characterize VBN cord-014516-r59usk02 543 6 by by IN cord-014516-r59usk02 543 7 progressive progressive JJ cord-014516-r59usk02 543 8 weight weight NN cord-014516-r59usk02 543 9 loss loss NN cord-014516-r59usk02 543 10 and and CC cord-014516-r59usk02 543 11 depletion depletion NN cord-014516-r59usk02 543 12 of of IN cord-014516-r59usk02 543 13 lean lean JJ cord-014516-r59usk02 543 14 body body NN cord-014516-r59usk02 543 15 mass mass NN cord-014516-r59usk02 543 16 , , , cord-014516-r59usk02 543 17 is be VBZ cord-014516-r59usk02 543 18 an an DT cord-014516-r59usk02 543 19 independent independent JJ cord-014516-r59usk02 543 20 predictor predictor NN cord-014516-r59usk02 543 21 of of IN cord-014516-r59usk02 543 22 survival survival NN cord-014516-r59usk02 543 23 in in IN cord-014516-r59usk02 543 24 human human JJ cord-014516-r59usk02 543 25 patients patient NNS cord-014516-r59usk02 543 26 with with IN cord-014516-r59usk02 543 27 congestive congestive JJ cord-014516-r59usk02 543 28 heart heart NN cord-014516-r59usk02 543 29 failure failure NN cord-014516-r59usk02 543 30 . . . cord-014516-r59usk02 544 1 Chronic chronic JJ cord-014516-r59usk02 544 2 degenerative degenerative JJ cord-014516-r59usk02 544 3 mitral mitral JJ cord-014516-r59usk02 544 4 valve valve NN cord-014516-r59usk02 544 5 disease disease NN cord-014516-r59usk02 544 6 ( ( -LRB- cord-014516-r59usk02 544 7 CDMD CDMD NNP cord-014516-r59usk02 544 8 ) ) -RRB- cord-014516-r59usk02 544 9 is be VBZ cord-014516-r59usk02 544 10 one one CD cord-014516-r59usk02 544 11 of of IN cord-014516-r59usk02 544 12 the the DT cord-014516-r59usk02 544 13 most most RBS cord-014516-r59usk02 544 14 common common JJ cord-014516-r59usk02 544 15 cardiac cardiac JJ cord-014516-r59usk02 544 16 diseases disease NNS cord-014516-r59usk02 544 17 in in IN cord-014516-r59usk02 544 18 dogs dog NNS cord-014516-r59usk02 544 19 . . . cord-014516-r59usk02 545 1 The the DT cord-014516-r59usk02 545 2 aims aim NNS cord-014516-r59usk02 545 3 of of IN cord-014516-r59usk02 545 4 this this DT cord-014516-r59usk02 545 5 study study NN cord-014516-r59usk02 545 6 were be VBD cord-014516-r59usk02 545 7 to to TO cord-014516-r59usk02 545 8 evaluate evaluate VB cord-014516-r59usk02 545 9 the the DT cord-014516-r59usk02 545 10 prevalence prevalence NN cord-014516-r59usk02 545 11 and and CC cord-014516-r59usk02 545 12 the the DT cord-014516-r59usk02 545 13 effects effect NNS cord-014516-r59usk02 545 14 of of IN cord-014516-r59usk02 545 15 cardiac cardiac JJ cord-014516-r59usk02 545 16 cachexia cachexia NN cord-014516-r59usk02 545 17 in in IN cord-014516-r59usk02 545 18 survival survival NN cord-014516-r59usk02 545 19 of of IN cord-014516-r59usk02 545 20 dogs dog NNS cord-014516-r59usk02 545 21 with with IN cord-014516-r59usk02 545 22 CDMD CDMD NNP cord-014516-r59usk02 545 23 . . . cord-014516-r59usk02 546 1 Medical medical JJ cord-014516-r59usk02 546 2 records record NNS cord-014516-r59usk02 546 3 of of IN cord-014516-r59usk02 546 4 114 114 CD cord-014516-r59usk02 546 5 client client NN cord-014516-r59usk02 546 6 - - HYPH cord-014516-r59usk02 546 7 owned own VBN cord-014516-r59usk02 546 8 dogs dog NNS cord-014516-r59usk02 546 9 with with IN cord-014516-r59usk02 546 10 CDMD CDMD NNP cord-014516-r59usk02 546 11 were be VBD cord-014516-r59usk02 546 12 reviewed review VBN cord-014516-r59usk02 546 13 . . . cord-014516-r59usk02 547 1 The the DT cord-014516-r59usk02 547 2 mean mean JJ cord-014516-r59usk02 547 3 age age NN cord-014516-r59usk02 547 4 at at IN cord-014516-r59usk02 547 5 entry entry NN cord-014516-r59usk02 547 6 was be VBD cord-014516-r59usk02 547 7 11.1 11.1 CD cord-014516-r59usk02 547 8 AE AE NNP cord-014516-r59usk02 547 9 3.2 3.2 CD cord-014516-r59usk02 547 10 years year NNS cord-014516-r59usk02 547 11 ; ; : cord-014516-r59usk02 547 12 73 73 CD cord-014516-r59usk02 547 13 were be VBD cord-014516-r59usk02 547 14 females female NNS cord-014516-r59usk02 547 15 , , , cord-014516-r59usk02 547 16 and and CC cord-014516-r59usk02 547 17 41 41 CD cord-014516-r59usk02 547 18 were be VBD cord-014516-r59usk02 547 19 males male NNS cord-014516-r59usk02 547 20 . . . cord-014516-r59usk02 548 1 Data datum NNS cord-014516-r59usk02 548 2 obtained obtain VBN cord-014516-r59usk02 548 3 from from IN cord-014516-r59usk02 548 4 the the DT cord-014516-r59usk02 548 5 records record NNS cord-014516-r59usk02 548 6 including include VBG cord-014516-r59usk02 548 7 breed breed NN cord-014516-r59usk02 548 8 , , , cord-014516-r59usk02 548 9 sex sex NN cord-014516-r59usk02 548 10 , , , cord-014516-r59usk02 548 11 body body NN cord-014516-r59usk02 548 12 weight weight NN cord-014516-r59usk02 548 13 , , , cord-014516-r59usk02 548 14 age age NN cord-014516-r59usk02 548 15 at at IN cord-014516-r59usk02 548 16 diagnosis diagnosis NN cord-014516-r59usk02 548 17 , , , cord-014516-r59usk02 548 18 complete complete JJ cord-014516-r59usk02 548 19 blood blood NN cord-014516-r59usk02 548 20 counts count NNS cord-014516-r59usk02 548 21 , , , cord-014516-r59usk02 548 22 biochemical biochemical JJ cord-014516-r59usk02 548 23 profiles profile NNS cord-014516-r59usk02 548 24 , , , cord-014516-r59usk02 548 25 urinalysis urinalysis NN cord-014516-r59usk02 548 26 , , , cord-014516-r59usk02 548 27 systemic systemic JJ cord-014516-r59usk02 548 28 blood blood NN cord-014516-r59usk02 548 29 pressure pressure NN cord-014516-r59usk02 548 30 , , , cord-014516-r59usk02 548 31 thoracic thoracic JJ cord-014516-r59usk02 548 32 radiographs radiograph NNS cord-014516-r59usk02 548 33 , , , cord-014516-r59usk02 548 34 electrocardiograms electrocardiogram NNS cord-014516-r59usk02 548 35 , , , cord-014516-r59usk02 548 36 ultrasonography ultrasonography NN cord-014516-r59usk02 548 37 and and CC cord-014516-r59usk02 548 38 echocardiographic echocardiographic JJ cord-014516-r59usk02 548 39 examinations examination NNS cord-014516-r59usk02 548 40 at at IN cord-014516-r59usk02 548 41 initial initial JJ cord-014516-r59usk02 548 42 visit visit NN cord-014516-r59usk02 548 43 and and CC cord-014516-r59usk02 548 44 survival survival NN cord-014516-r59usk02 548 45 time time NN cord-014516-r59usk02 548 46 . . . cord-014516-r59usk02 549 1 Diagnosis diagnosis NN cord-014516-r59usk02 549 2 of of IN cord-014516-r59usk02 549 3 CDMD CDMD NNP cord-014516-r59usk02 549 4 was be VBD cord-014516-r59usk02 549 5 based base VBN cord-014516-r59usk02 549 6 on on IN cord-014516-r59usk02 549 7 echocardiographic echocardiographic JJ cord-014516-r59usk02 549 8 characteristics characteristic NNS cord-014516-r59usk02 549 9 and and CC cord-014516-r59usk02 549 10 categorized categorize VBN cord-014516-r59usk02 549 11 by by IN cord-014516-r59usk02 549 12 modified modify VBN cord-014516-r59usk02 549 13 New New NNP cord-014516-r59usk02 549 14 York York NNP cord-014516-r59usk02 549 15 Heart Heart NNP cord-014516-r59usk02 549 16 Association Association NNP cord-014516-r59usk02 549 17 ( ( -LRB- cord-014516-r59usk02 549 18 NYHA NYHA NNP cord-014516-r59usk02 549 19 ) ) -RRB- cord-014516-r59usk02 549 20 functional functional JJ cord-014516-r59usk02 549 21 classification classification NN cord-014516-r59usk02 549 22 . . . cord-014516-r59usk02 550 1 Cardiac cardiac JJ cord-014516-r59usk02 550 2 cachexia cachexia NN cord-014516-r59usk02 550 3 was be VBD cord-014516-r59usk02 550 4 defined define VBN cord-014516-r59usk02 550 5 as as IN cord-014516-r59usk02 550 6 presence presence NN cord-014516-r59usk02 550 7 unintentional unintentional JJ cord-014516-r59usk02 550 8 weight weight NN cord-014516-r59usk02 550 9 loss loss NN cord-014516-r59usk02 550 10 ( ( -LRB- cord-014516-r59usk02 550 11 > > NFP cord-014516-r59usk02 550 12 5 5 CD cord-014516-r59usk02 550 13 % % NN cord-014516-r59usk02 550 14 within within IN cord-014516-r59usk02 550 15 12 12 CD cord-014516-r59usk02 550 16 months month NNS cord-014516-r59usk02 550 17 after after IN cord-014516-r59usk02 550 18 diagnosis diagnosis NN cord-014516-r59usk02 550 19 ) ) -RRB- cord-014516-r59usk02 550 20 together together RB cord-014516-r59usk02 550 21 with with IN cord-014516-r59usk02 550 22 anorexia anorexia NN cord-014516-r59usk02 550 23 and and CC cord-014516-r59usk02 550 24 muscle muscle NN cord-014516-r59usk02 550 25 weakness weakness NN cord-014516-r59usk02 550 26 , , , cord-014516-r59usk02 550 27 anemia anemia NN cord-014516-r59usk02 550 28 ( ( -LRB- cord-014516-r59usk02 550 29 red red JJ cord-014516-r59usk02 550 30 cell cell NN cord-014516-r59usk02 550 31 count count NN cord-014516-r59usk02 550 32 < < XX cord-014516-r59usk02 550 33 5.5 5.5 CD cord-014516-r59usk02 550 34 10 10 CD cord-014516-r59usk02 550 35 6 6 CD cord-014516-r59usk02 550 36 /lL /ll CD cord-014516-r59usk02 550 37 , , , cord-014516-r59usk02 550 38 hemoglobin hemoglobin NN cord-014516-r59usk02 550 39 < < XX cord-014516-r59usk02 550 40 12 12 CD cord-014516-r59usk02 550 41 g g NN cord-014516-r59usk02 550 42 / / SYM cord-014516-r59usk02 550 43 dL dl NN cord-014516-r59usk02 550 44 , , , cord-014516-r59usk02 550 45 or or CC cord-014516-r59usk02 550 46 both both DT cord-014516-r59usk02 550 47 ) ) -RRB- cord-014516-r59usk02 551 1 , , , cord-014516-r59usk02 551 2 hypoalbuminemia hypoalbuminemia NNP cord-014516-r59usk02 551 3 ( ( -LRB- cord-014516-r59usk02 551 4 plasma plasma NN cord-014516-r59usk02 551 5 albumin albumin NN cord-014516-r59usk02 551 6 < < XX cord-014516-r59usk02 551 7 3.0 3.0 CD cord-014516-r59usk02 551 8 g g NN cord-014516-r59usk02 551 9 / / SYM cord-014516-r59usk02 551 10 dL dl NN cord-014516-r59usk02 551 11 ) ) -RRB- cord-014516-r59usk02 551 12 , , , cord-014516-r59usk02 551 13 and and CC cord-014516-r59usk02 551 14 azotemia azotemia NN cord-014516-r59usk02 551 15 ( ( -LRB- cord-014516-r59usk02 551 16 blood blood NN cord-014516-r59usk02 551 17 urea urea NN cord-014516-r59usk02 551 18 nitrogen nitrogen NN cord-014516-r59usk02 551 19 > > XX cord-014516-r59usk02 551 20 26 26 CD cord-014516-r59usk02 551 21 g g NN cord-014516-r59usk02 551 22 / / SYM cord-014516-r59usk02 551 23 dL dl NN cord-014516-r59usk02 551 24 , , , cord-014516-r59usk02 551 25 creatinine creatinine NN cord-014516-r59usk02 551 26 > > XX cord-014516-r59usk02 551 27 1.6 1.6 CD cord-014516-r59usk02 551 28 g g NN cord-014516-r59usk02 551 29 / / SYM cord-014516-r59usk02 551 30 dL dl NN cord-014516-r59usk02 551 31 , , , cord-014516-r59usk02 551 32 or or CC cord-014516-r59usk02 551 33 both both DT cord-014516-r59usk02 551 34 ) ) -RRB- cord-014516-r59usk02 551 35 . . . cord-014516-r59usk02 552 1 Dogs dog NNS cord-014516-r59usk02 552 2 with with IN cord-014516-r59usk02 552 3 other other JJ cord-014516-r59usk02 552 4 cardiac cardiac JJ cord-014516-r59usk02 552 5 disorders disorder NNS cord-014516-r59usk02 552 6 and and CC cord-014516-r59usk02 552 7 other other JJ cord-014516-r59usk02 552 8 systemic systemic JJ cord-014516-r59usk02 552 9 disorders disorder NNS cord-014516-r59usk02 552 10 those those DT cord-014516-r59usk02 552 11 would would MD cord-014516-r59usk02 552 12 cause cause VB cord-014516-r59usk02 552 13 anemia anemia NN cord-014516-r59usk02 552 14 and and CC cord-014516-r59usk02 552 15 hypoalbuminemia hypoalbuminemia NN cord-014516-r59usk02 552 16 were be VBD cord-014516-r59usk02 552 17 excluded exclude VBN cord-014516-r59usk02 552 18 from from IN cord-014516-r59usk02 552 19 this this DT cord-014516-r59usk02 552 20 study study NN cord-014516-r59usk02 552 21 . . . cord-014516-r59usk02 553 1 Prevalence prevalence NN cord-014516-r59usk02 553 2 of of IN cord-014516-r59usk02 553 3 cardiac cardiac JJ cord-014516-r59usk02 553 4 cachexia cachexia NN cord-014516-r59usk02 553 5 , , , cord-014516-r59usk02 553 6 anemia anemia NN cord-014516-r59usk02 553 7 and and CC cord-014516-r59usk02 553 8 azotemia azotemia NN cord-014516-r59usk02 553 9 was be VBD cord-014516-r59usk02 553 10 32.5 32.5 CD cord-014516-r59usk02 553 11 % % NN cord-014516-r59usk02 553 12 , , , cord-014516-r59usk02 553 13 15.8 15.8 CD cord-014516-r59usk02 553 14 % % NN cord-014516-r59usk02 553 15 and and CC cord-014516-r59usk02 553 16 45.6 45.6 CD cord-014516-r59usk02 553 17 % % NN cord-014516-r59usk02 553 18 , , , cord-014516-r59usk02 553 19 respectively respectively RB cord-014516-r59usk02 553 20 . . . cord-014516-r59usk02 554 1 These these DT cord-014516-r59usk02 554 2 conditions condition NNS cord-014516-r59usk02 554 3 were be VBD cord-014516-r59usk02 554 4 the the DT cord-014516-r59usk02 554 5 most most RBS cord-014516-r59usk02 554 6 prevalent prevalent JJ cord-014516-r59usk02 554 7 in in IN cord-014516-r59usk02 554 8 NYHA NYHA NNP cord-014516-r59usk02 554 9 class class NN cord-014516-r59usk02 554 10 4 4 CD cord-014516-r59usk02 554 11 , , , cord-014516-r59usk02 554 12 followed follow VBN cord-014516-r59usk02 554 13 by by IN cord-014516-r59usk02 554 14 NYHA NYHA NNP cord-014516-r59usk02 554 15 classes class NNS cord-014516-r59usk02 554 16 3 3 CD cord-014516-r59usk02 554 17 and and CC cord-014516-r59usk02 554 18 2 2 CD cord-014516-r59usk02 554 19 . . . cord-014516-r59usk02 555 1 The the DT cord-014516-r59usk02 555 2 prevalence prevalence NN cord-014516-r59usk02 555 3 of of IN cord-014516-r59usk02 555 4 hypoalbuminemia hypoalbuminemia NN cord-014516-r59usk02 555 5 was be VBD cord-014516-r59usk02 555 6 not not RB cord-014516-r59usk02 555 7 significantly significantly RB cord-014516-r59usk02 555 8 different different JJ cord-014516-r59usk02 555 9 among among IN cord-014516-r59usk02 555 10 classes class NNS cord-014516-r59usk02 555 11 . . . cord-014516-r59usk02 556 1 The the DT cord-014516-r59usk02 556 2 one one CD cord-014516-r59usk02 556 3 - - HYPH cord-014516-r59usk02 556 4 year year NN cord-014516-r59usk02 556 5 body body NN cord-014516-r59usk02 556 6 weight weight NN cord-014516-r59usk02 556 7 change change NN cord-014516-r59usk02 556 8 was be VBD cord-014516-r59usk02 556 9 found find VBN cord-014516-r59usk02 556 10 in in IN cord-014516-r59usk02 556 11 the the DT cord-014516-r59usk02 556 12 NYHA NYHA NNP cord-014516-r59usk02 556 13 classes class NNS cord-014516-r59usk02 556 14 2 2 CD cord-014516-r59usk02 556 15 ( ( -LRB- cord-014516-r59usk02 556 16 increased increase VBN cord-014516-r59usk02 556 17 2.7 2.7 CD cord-014516-r59usk02 556 18 AE AE NNP cord-014516-r59usk02 556 19 10.7 10.7 CD cord-014516-r59usk02 556 20 % % NN cord-014516-r59usk02 556 21 ) ) -RRB- cord-014516-r59usk02 556 22 , , , cord-014516-r59usk02 556 23 3 3 CD cord-014516-r59usk02 556 24 ( ( -LRB- cord-014516-r59usk02 556 25 decreased decrease VBD cord-014516-r59usk02 556 26 1.3 1.3 CD cord-014516-r59usk02 556 27 AE AE NNP cord-014516-r59usk02 556 28 12.3 12.3 CD cord-014516-r59usk02 556 29 % % NN cord-014516-r59usk02 556 30 ) ) -RRB- cord-014516-r59usk02 556 31 and and CC cord-014516-r59usk02 556 32 4 4 LS cord-014516-r59usk02 556 33 ( ( -LRB- cord-014516-r59usk02 556 34 decreased decrease VBD cord-014516-r59usk02 556 35 6.1 6.1 CD cord-014516-r59usk02 556 36 AE AE NNP cord-014516-r59usk02 556 37 9.5 9.5 CD cord-014516-r59usk02 556 38 % % NN cord-014516-r59usk02 556 39 ) ) -RRB- cord-014516-r59usk02 556 40 . . . cord-014516-r59usk02 557 1 The the DT cord-014516-r59usk02 557 2 difference difference NN cord-014516-r59usk02 557 3 between between IN cord-014516-r59usk02 557 4 classes class NNS cord-014516-r59usk02 557 5 4 4 CD cord-014516-r59usk02 557 6 and and CC cord-014516-r59usk02 557 7 2 2 CD cord-014516-r59usk02 557 8 was be VBD cord-014516-r59usk02 557 9 significant significant JJ cord-014516-r59usk02 557 10 . . . cord-014516-r59usk02 558 1 Results result NNS cord-014516-r59usk02 558 2 of of IN cord-014516-r59usk02 558 3 the the DT cord-014516-r59usk02 558 4 Cox Cox NNP cord-014516-r59usk02 558 5 proportional proportional JJ cord-014516-r59usk02 558 6 hazard hazard NN cord-014516-r59usk02 558 7 model model NN cord-014516-r59usk02 558 8 indicated indicate VBD cord-014516-r59usk02 558 9 that that IN cord-014516-r59usk02 558 10 survival survival NN cord-014516-r59usk02 558 11 time time NN cord-014516-r59usk02 558 12 was be VBD cord-014516-r59usk02 558 13 significantly significantly RB cord-014516-r59usk02 558 14 positively positively RB cord-014516-r59usk02 558 15 associated associate VBN cord-014516-r59usk02 558 16 with with IN cord-014516-r59usk02 558 17 NYHA NYHA NNP cord-014516-r59usk02 558 18 functional functional JJ cord-014516-r59usk02 558 19 severity severity NN cord-014516-r59usk02 558 20 at at IN cord-014516-r59usk02 558 21 diagnosis diagnosis NN cord-014516-r59usk02 558 22 ( ( -LRB- cord-014516-r59usk02 558 23 P p NN cord-014516-r59usk02 558 24 < < XX cord-014516-r59usk02 558 25 0.001 0.001 CD cord-014516-r59usk02 558 26 ) ) -RRB- cord-014516-r59usk02 558 27 , , , cord-014516-r59usk02 558 28 presence presence NN cord-014516-r59usk02 558 29 of of IN cord-014516-r59usk02 558 30 cardiac cardiac JJ cord-014516-r59usk02 558 31 cachexia cachexia NN cord-014516-r59usk02 558 32 , , , cord-014516-r59usk02 558 33 weight weight NN cord-014516-r59usk02 558 34 loss loss NN cord-014516-r59usk02 558 35 , , , cord-014516-r59usk02 558 36 anemia anemia NN cord-014516-r59usk02 558 37 , , , cord-014516-r59usk02 558 38 hypoalbuminemia hypoalbuminemia NN cord-014516-r59usk02 558 39 and and CC cord-014516-r59usk02 558 40 azotemia azotemia NNP cord-014516-r59usk02 558 41 ( ( -LRB- cord-014516-r59usk02 558 42 P p NN cord-014516-r59usk02 558 43 < < XX cord-014516-r59usk02 558 44 0.001 0.001 CD cord-014516-r59usk02 558 45 , , , cord-014516-r59usk02 558 46 P p NN cord-014516-r59usk02 558 47 = = SYM cord-014516-r59usk02 558 48 0.003 0.003 CD cord-014516-r59usk02 558 49 , , , cord-014516-r59usk02 558 50 P p NN cord-014516-r59usk02 558 51 = = SYM cord-014516-r59usk02 558 52 0.0033 0.0033 CD cord-014516-r59usk02 558 53 , , , cord-014516-r59usk02 558 54 P p NN cord-014516-r59usk02 558 55 = = SYM cord-014516-r59usk02 558 56 0.003 0.003 CD cord-014516-r59usk02 558 57 and and CC cord-014516-r59usk02 558 58 P p NN cord-014516-r59usk02 558 59 = = SYM cord-014516-r59usk02 558 60 0.019 0.019 CD cord-014516-r59usk02 558 61 , , , cord-014516-r59usk02 558 62 respectively respectively RB cord-014516-r59usk02 558 63 ) ) -RRB- cord-014516-r59usk02 558 64 . . . cord-014516-r59usk02 559 1 The the DT cord-014516-r59usk02 559 2 prevalence prevalence NN cord-014516-r59usk02 559 3 of of IN cord-014516-r59usk02 559 4 cardiac cardiac JJ cord-014516-r59usk02 559 5 cachexia cachexia NN cord-014516-r59usk02 559 6 was be VBD cord-014516-r59usk02 559 7 common common JJ cord-014516-r59usk02 559 8 in in IN cord-014516-r59usk02 559 9 advanced advanced JJ cord-014516-r59usk02 559 10 CDMD CDMD NNP cord-014516-r59usk02 559 11 dogs dog NNS cord-014516-r59usk02 559 12 , , , cord-014516-r59usk02 559 13 and and CC cord-014516-r59usk02 559 14 the the DT cord-014516-r59usk02 559 15 parameters parameter NNS cord-014516-r59usk02 559 16 of of IN cord-014516-r59usk02 559 17 cardiac cardiac JJ cord-014516-r59usk02 559 18 cachexia cachexia NN cord-014516-r59usk02 559 19 , , , cord-014516-r59usk02 559 20 namely namely RB cord-014516-r59usk02 559 21 weight weight NN cord-014516-r59usk02 559 22 loss loss NN cord-014516-r59usk02 559 23 , , , cord-014516-r59usk02 559 24 anemia anemia NN cord-014516-r59usk02 559 25 , , , cord-014516-r59usk02 559 26 hypoalbuminemia hypoalbuminemia NN cord-014516-r59usk02 559 27 and and CC cord-014516-r59usk02 559 28 azotemia azotemia NNP cord-014516-r59usk02 559 29 were be VBD cord-014516-r59usk02 559 30 strong strong JJ cord-014516-r59usk02 559 31 prognostic prognostic JJ cord-014516-r59usk02 559 32 factors factor NNS cord-014516-r59usk02 559 33 associated associate VBN cord-014516-r59usk02 559 34 with with IN cord-014516-r59usk02 559 35 survival survival NN cord-014516-r59usk02 559 36 . . . cord-014516-r59usk02 560 1 No no DT cord-014516-r59usk02 560 2 conflicts conflict NNS cord-014516-r59usk02 560 3 of of IN cord-014516-r59usk02 560 4 interest interest NN cord-014516-r59usk02 560 5 reported report VBN cord-014516-r59usk02 560 6 . . . cord-014516-r59usk02 561 1 Mitral mitral JJ cord-014516-r59usk02 561 2 valve valve NN cord-014516-r59usk02 561 3 disease disease NN cord-014516-r59usk02 561 4 ( ( -LRB- cord-014516-r59usk02 561 5 MVD MVD NNP cord-014516-r59usk02 561 6 ) ) -RRB- cord-014516-r59usk02 561 7 is be VBZ cord-014516-r59usk02 561 8 the the DT cord-014516-r59usk02 561 9 most most RBS cord-014516-r59usk02 561 10 common common JJ cord-014516-r59usk02 561 11 cardiovascular cardiovascular JJ cord-014516-r59usk02 561 12 disease disease NN cord-014516-r59usk02 561 13 in in IN cord-014516-r59usk02 561 14 dogs dog NNS cord-014516-r59usk02 561 15 . . . cord-014516-r59usk02 562 1 It -PRON- PRP cord-014516-r59usk02 562 2 's be VBZ cord-014516-r59usk02 562 3 characterized characterize VBN cord-014516-r59usk02 562 4 by by IN cord-014516-r59usk02 562 5 myxomatous myxomatous JJ cord-014516-r59usk02 562 6 degeneration degeneration NN cord-014516-r59usk02 562 7 , , , cord-014516-r59usk02 562 8 which which WDT cord-014516-r59usk02 562 9 causes cause VBZ cord-014516-r59usk02 562 10 mitral mitral JJ cord-014516-r59usk02 562 11 valve valve NN cord-014516-r59usk02 562 12 prolapse prolapse NN cord-014516-r59usk02 562 13 ( ( -LRB- cord-014516-r59usk02 562 14 MVP MVP NNP cord-014516-r59usk02 562 15 ) ) -RRB- cord-014516-r59usk02 562 16 , , , cord-014516-r59usk02 562 17 mitral mitral JJ cord-014516-r59usk02 562 18 regurgitation regurgitation NN cord-014516-r59usk02 562 19 ( ( -LRB- cord-014516-r59usk02 562 20 MR MR NNP cord-014516-r59usk02 562 21 ) ) -RRB- cord-014516-r59usk02 562 22 and and CC cord-014516-r59usk02 562 23 a a DT cord-014516-r59usk02 562 24 left left JJ cord-014516-r59usk02 562 25 apical apical JJ cord-014516-r59usk02 562 26 systolic systolic JJ cord-014516-r59usk02 562 27 murmur murmur NN cord-014516-r59usk02 562 28 ( ( -LRB- cord-014516-r59usk02 562 29 LASM LASM NNP cord-014516-r59usk02 562 30 ) ) -RRB- cord-014516-r59usk02 562 31 . . . cord-014516-r59usk02 563 1 MVD MVD NNP cord-014516-r59usk02 563 2 affects affect VBZ cord-014516-r59usk02 563 3 small small JJ cord-014516-r59usk02 563 4 breed breed NN cord-014516-r59usk02 563 5 dogs dog NNS cord-014516-r59usk02 563 6 with with IN cord-014516-r59usk02 563 7 a a DT cord-014516-r59usk02 563 8 very very RB cord-014516-r59usk02 563 9 high high JJ cord-014516-r59usk02 563 10 prevalence prevalence NN cord-014516-r59usk02 563 11 in in IN cord-014516-r59usk02 563 12 Cavalier Cavalier NNP cord-014516-r59usk02 563 13 King King NNP cord-014516-r59usk02 563 14 Charles Charles NNP cord-014516-r59usk02 563 15 Spaniels Spaniels NNPS cord-014516-r59usk02 564 1 ( ( -LRB- cord-014516-r59usk02 564 2 CKCS CKCS NNP cord-014516-r59usk02 564 3 ) ) -RRB- cord-014516-r59usk02 564 4 . . . cord-014516-r59usk02 565 1 The the DT cord-014516-r59usk02 565 2 main main JJ cord-014516-r59usk02 565 3 goal goal NN cord-014516-r59usk02 565 4 of of IN cord-014516-r59usk02 565 5 this this DT cord-014516-r59usk02 565 6 study study NN cord-014516-r59usk02 565 7 was be VBD cord-014516-r59usk02 565 8 to to TO cord-014516-r59usk02 565 9 determine determine VB cord-014516-r59usk02 565 10 the the DT cord-014516-r59usk02 565 11 prevalence prevalence NN cord-014516-r59usk02 565 12 of of IN cord-014516-r59usk02 565 13 LASM LASM NNP cord-014516-r59usk02 565 14 , , , cord-014516-r59usk02 565 15 MVP MVP NNP cord-014516-r59usk02 565 16 and and CC cord-014516-r59usk02 565 17 MR MR NNP cord-014516-r59usk02 565 18 in in IN cord-014516-r59usk02 565 19 the the DT cord-014516-r59usk02 565 20 Maltese Maltese NNP cord-014516-r59usk02 565 21 , , , cord-014516-r59usk02 565 22 the the DT cord-014516-r59usk02 565 23 most most RBS cord-014516-r59usk02 565 24 presented present VBN cord-014516-r59usk02 565 25 breed breed NN cord-014516-r59usk02 565 26 among among IN cord-014516-r59usk02 565 27 dogs dog NNS cord-014516-r59usk02 565 28 with with IN cord-014516-r59usk02 565 29 MVD MVD NNP cord-014516-r59usk02 565 30 in in IN cord-014516-r59usk02 565 31 Taiwan Taiwan NNP cord-014516-r59usk02 565 32 . . . cord-014516-r59usk02 566 1 The the DT cord-014516-r59usk02 566 2 correlation correlation NN cord-014516-r59usk02 566 3 between between IN cord-014516-r59usk02 566 4 these these DT cord-014516-r59usk02 566 5 3 3 CD cord-014516-r59usk02 566 6 measurements measurement NNS cord-014516-r59usk02 566 7 and and CC cord-014516-r59usk02 566 8 the the DT cord-014516-r59usk02 566 9 influence influence NN cord-014516-r59usk02 566 10 of of IN cord-014516-r59usk02 566 11 age age NN cord-014516-r59usk02 566 12 , , , cord-014516-r59usk02 566 13 gender gender NN cord-014516-r59usk02 566 14 , , , cord-014516-r59usk02 566 15 reproductive reproductive JJ cord-014516-r59usk02 566 16 state state NN cord-014516-r59usk02 566 17 , , , cord-014516-r59usk02 566 18 and and CC cord-014516-r59usk02 566 19 body body NN cord-014516-r59usk02 566 20 weight weight NN cord-014516-r59usk02 566 21 were be VBD cord-014516-r59usk02 566 22 also also RB cord-014516-r59usk02 566 23 investigated investigate VBN cord-014516-r59usk02 566 24 . . . cord-014516-r59usk02 567 1 Study study NN cord-014516-r59usk02 567 2 results result NNS cord-014516-r59usk02 567 3 were be VBD cord-014516-r59usk02 567 4 compared compare VBN cord-014516-r59usk02 567 5 to to IN cord-014516-r59usk02 567 6 other other JJ cord-014516-r59usk02 567 7 MVD MVD NNP cord-014516-r59usk02 567 8 prevalence prevalence NN cord-014516-r59usk02 567 9 studies study NNS cord-014516-r59usk02 567 10 in in IN cord-014516-r59usk02 567 11 Europe Europe NNP cord-014516-r59usk02 567 12 and and CC cord-014516-r59usk02 567 13 North North NNP cord-014516-r59usk02 567 14 - - HYPH cord-014516-r59usk02 567 15 America America NNP cord-014516-r59usk02 567 16 . . . cord-014516-r59usk02 568 1 162 162 CD cord-014516-r59usk02 568 2 client client NN cord-014516-r59usk02 568 3 - - HYPH cord-014516-r59usk02 568 4 owned own VBN cord-014516-r59usk02 568 5 Maltese maltese JJ cord-014516-r59usk02 568 6 dogs dog NNS cord-014516-r59usk02 568 7 ( ( -LRB- cord-014516-r59usk02 568 8 75 75 CD cord-014516-r59usk02 568 9 males male NNS cord-014516-r59usk02 568 10 and and CC cord-014516-r59usk02 568 11 87 87 CD cord-014516-r59usk02 568 12 females female NNS cord-014516-r59usk02 568 13 ; ; : cord-014516-r59usk02 568 14 body body NN cord-014516-r59usk02 568 15 weight weight NN cord-014516-r59usk02 568 16 1.35 1.35 CD cord-014516-r59usk02 568 17 - - HYPH cord-014516-r59usk02 568 18 7.15 7.15 CD cord-014516-r59usk02 568 19 kg kg NNS cord-014516-r59usk02 568 20 ; ; : cord-014516-r59usk02 568 21 age age NN cord-014516-r59usk02 568 22 2 2 CD cord-014516-r59usk02 568 23 - - SYM cord-014516-r59usk02 568 24 15 15 CD cord-014516-r59usk02 568 25 yrs yr NNS cord-014516-r59usk02 568 26 ) ) -RRB- cord-014516-r59usk02 568 27 with with IN cord-014516-r59usk02 568 28 no no DT cord-014516-r59usk02 568 29 signs sign NNS cord-014516-r59usk02 568 30 of of IN cord-014516-r59usk02 568 31 heart heart NN cord-014516-r59usk02 568 32 failure failure NN cord-014516-r59usk02 568 33 were be VBD cord-014516-r59usk02 568 34 recruited recruit VBN cord-014516-r59usk02 568 35 . . . cord-014516-r59usk02 569 1 The the DT cord-014516-r59usk02 569 2 intensity intensity NN cord-014516-r59usk02 569 3 ( ( -LRB- cord-014516-r59usk02 569 4 grade grade NN cord-014516-r59usk02 569 5 1 1 CD cord-014516-r59usk02 569 6 - - SYM cord-014516-r59usk02 569 7 6 6 CD cord-014516-r59usk02 569 8 ) ) -RRB- cord-014516-r59usk02 569 9 of of IN cord-014516-r59usk02 569 10 LASM LASM NNP cord-014516-r59usk02 569 11 was be VBD cord-014516-r59usk02 569 12 recorded record VBN cord-014516-r59usk02 569 13 . . . cord-014516-r59usk02 570 1 Grade grade NN cord-014516-r59usk02 570 2 of of IN cord-014516-r59usk02 570 3 MVP MVP NNP cord-014516-r59usk02 570 4 ( ( -LRB- cord-014516-r59usk02 570 5 mild mild JJ cord-014516-r59usk02 570 6 / / SYM cord-014516-r59usk02 570 7 severe severe JJ cord-014516-r59usk02 570 8 ) ) -RRB- cord-014516-r59usk02 570 9 and and CC cord-014516-r59usk02 570 10 MR MR NNP cord-014516-r59usk02 570 11 severity severity NN cord-014516-r59usk02 570 12 ( ( -LRB- cord-014516-r59usk02 570 13 mild mild JJ cord-014516-r59usk02 570 14 / / SYM cord-014516-r59usk02 570 15 moderate/ moderate/ NN cord-014516-r59usk02 570 16 severe severe JJ cord-014516-r59usk02 570 17 ) ) -RRB- cord-014516-r59usk02 570 18 were be VBD cord-014516-r59usk02 570 19 evaluated evaluate VBN cord-014516-r59usk02 570 20 by by IN cord-014516-r59usk02 570 21 echocardiography echocardiography NN cord-014516-r59usk02 570 22 . . . cord-014516-r59usk02 571 1 Logistic logistic JJ cord-014516-r59usk02 571 2 regression regression NN cord-014516-r59usk02 571 3 was be VBD cord-014516-r59usk02 571 4 used use VBN cord-014516-r59usk02 571 5 to to TO cord-014516-r59usk02 571 6 determine determine VB cord-014516-r59usk02 571 7 the the DT cord-014516-r59usk02 571 8 correlation correlation NN cord-014516-r59usk02 571 9 between between IN cord-014516-r59usk02 571 10 age age NN cord-014516-r59usk02 571 11 and and CC cord-014516-r59usk02 571 12 presence presence NN cord-014516-r59usk02 571 13 of of IN cord-014516-r59usk02 571 14 LASM LASM NNP cord-014516-r59usk02 571 15 , , , cord-014516-r59usk02 571 16 MVP MVP NNP cord-014516-r59usk02 571 17 and and CC cord-014516-r59usk02 571 18 MR MR NNP cord-014516-r59usk02 571 19 . . . cord-014516-r59usk02 572 1 A a DT cord-014516-r59usk02 572 2 Chi Chi NNP cord-014516-r59usk02 572 3 - - HYPH cord-014516-r59usk02 572 4 square square JJ cord-014516-r59usk02 572 5 test test NN cord-014516-r59usk02 572 6 was be VBD cord-014516-r59usk02 572 7 used use VBN cord-014516-r59usk02 572 8 to to TO cord-014516-r59usk02 572 9 evaluate evaluate VB cord-014516-r59usk02 572 10 whether whether IN cord-014516-r59usk02 572 11 sex sex NN cord-014516-r59usk02 572 12 and and CC cord-014516-r59usk02 572 13 reproductive reproductive JJ cord-014516-r59usk02 572 14 - - HYPH cord-014516-r59usk02 572 15 status status NN cord-014516-r59usk02 572 16 were be VBD cord-014516-r59usk02 572 17 related relate VBN cord-014516-r59usk02 572 18 to to IN cord-014516-r59usk02 572 19 prevalences prevalence NNS cord-014516-r59usk02 572 20 of of IN cord-014516-r59usk02 572 21 LASM LASM NNP cord-014516-r59usk02 572 22 , , , cord-014516-r59usk02 572 23 MVP MVP NNP cord-014516-r59usk02 572 24 and and CC cord-014516-r59usk02 572 25 MR MR NNP cord-014516-r59usk02 572 26 . . . cord-014516-r59usk02 573 1 Spearman Spearman NNP cord-014516-r59usk02 573 2 's 's POS cord-014516-r59usk02 573 3 correlation correlation NN cord-014516-r59usk02 573 4 coefficient coefficient NN cord-014516-r59usk02 573 5 was be VBD cord-014516-r59usk02 573 6 used use VBN cord-014516-r59usk02 573 7 to to TO cord-014516-r59usk02 573 8 assess assess VB cord-014516-r59usk02 573 9 the the DT cord-014516-r59usk02 573 10 relationships relationship NNS cord-014516-r59usk02 573 11 between between IN cord-014516-r59usk02 573 12 age age NN cord-014516-r59usk02 573 13 , , , cord-014516-r59usk02 573 14 body body NN cord-014516-r59usk02 573 15 weight weight NN cord-014516-r59usk02 573 16 , , , cord-014516-r59usk02 573 17 LASM lasm JJ cord-014516-r59usk02 573 18 intensity intensity NN cord-014516-r59usk02 573 19 , , , cord-014516-r59usk02 573 20 grade grade NN cord-014516-r59usk02 573 21 of of IN cord-014516-r59usk02 573 22 MVP MVP NNP cord-014516-r59usk02 573 23 and and CC cord-014516-r59usk02 573 24 severity severity NN cord-014516-r59usk02 573 25 of of IN cord-014516-r59usk02 573 26 MR MR NNP cord-014516-r59usk02 573 27 . . . cord-014516-r59usk02 574 1 The the DT cord-014516-r59usk02 574 2 prevalence prevalence NN cord-014516-r59usk02 574 3 of of IN cord-014516-r59usk02 574 4 LASM LASM NNP cord-014516-r59usk02 574 5 , , , cord-014516-r59usk02 574 6 MVP MVP NNP cord-014516-r59usk02 574 7 and and CC cord-014516-r59usk02 574 8 MR MR NNP cord-014516-r59usk02 574 9 were be VBD cord-014516-r59usk02 574 10 28.4 28.4 CD cord-014516-r59usk02 574 11 % % NN cord-014516-r59usk02 574 12 , , , cord-014516-r59usk02 574 13 34 34 CD cord-014516-r59usk02 574 14 % % NN cord-014516-r59usk02 574 15 and and CC cord-014516-r59usk02 574 16 41.4 41.4 CD cord-014516-r59usk02 574 17 % % NN cord-014516-r59usk02 574 18 , , , cord-014516-r59usk02 574 19 respectively respectively RB cord-014516-r59usk02 574 20 . . . cord-014516-r59usk02 575 1 All all DT cord-014516-r59usk02 575 2 have have VBP cord-014516-r59usk02 575 3 positive positive JJ cord-014516-r59usk02 575 4 correlation correlation NN cord-014516-r59usk02 575 5 with with IN cord-014516-r59usk02 575 6 age age NN cord-014516-r59usk02 575 7 ( ( -LRB- cord-014516-r59usk02 575 8 p p NN cord-014516-r59usk02 575 9 = = SYM cord-014516-r59usk02 575 10 0.000 0.000 CD cord-014516-r59usk02 575 11 ) ) -RRB- cord-014516-r59usk02 575 12 . . . cord-014516-r59usk02 576 1 The the DT cord-014516-r59usk02 576 2 age age NN cord-014516-r59usk02 576 3 at at IN cord-014516-r59usk02 576 4 which which WDT cord-014516-r59usk02 576 5 50 50 CD cord-014516-r59usk02 576 6 % % NN cord-014516-r59usk02 576 7 of of IN cord-014516-r59usk02 576 8 the the DT cord-014516-r59usk02 576 9 dogs dog NNS cord-014516-r59usk02 576 10 had have VBD cord-014516-r59usk02 576 11 LASM LASM VBN cord-014516-r59usk02 576 12 , , , cord-014516-r59usk02 576 13 MVP MVP NNP cord-014516-r59usk02 576 14 and and CC cord-014516-r59usk02 576 15 MR MR NNP cord-014516-r59usk02 576 16 was be VBD cord-014516-r59usk02 576 17 7.7 7.7 CD cord-014516-r59usk02 576 18 , , , cord-014516-r59usk02 576 19 7.5 7.5 CD cord-014516-r59usk02 576 20 , , , cord-014516-r59usk02 576 21 and and CC cord-014516-r59usk02 576 22 5.6 5.6 CD cord-014516-r59usk02 576 23 years year NNS cord-014516-r59usk02 576 24 , , , cord-014516-r59usk02 576 25 respectively respectively RB cord-014516-r59usk02 576 26 . . . cord-014516-r59usk02 577 1 The the DT cord-014516-r59usk02 577 2 LASM lasm JJ cord-014516-r59usk02 577 3 intensity intensity NN cord-014516-r59usk02 577 4 , , , cord-014516-r59usk02 577 5 MVP MVP NNP cord-014516-r59usk02 577 6 grade grade NN cord-014516-r59usk02 577 7 and and CC cord-014516-r59usk02 577 8 MR MR NNP cord-014516-r59usk02 577 9 severity severity NN cord-014516-r59usk02 577 10 were be VBD cord-014516-r59usk02 577 11 all all DT cord-014516-r59usk02 577 12 positively positively RB cord-014516-r59usk02 577 13 correlated correlate VBN cord-014516-r59usk02 577 14 to to IN cord-014516-r59usk02 577 15 age age NN cord-014516-r59usk02 577 16 ( ( -LRB- cord-014516-r59usk02 577 17 all all DT cord-014516-r59usk02 577 18 p p NN cord-014516-r59usk02 577 19 = = SYM cord-014516-r59usk02 577 20 0.000 0.000 CD cord-014516-r59usk02 577 21 ) ) -RRB- cord-014516-r59usk02 577 22 and and CC cord-014516-r59usk02 577 23 had have VBD cord-014516-r59usk02 577 24 no no DT cord-014516-r59usk02 577 25 correlation correlation NN cord-014516-r59usk02 577 26 with with IN cord-014516-r59usk02 577 27 BW BW NNP cord-014516-r59usk02 577 28 and and CC cord-014516-r59usk02 577 29 reproductive reproductive JJ cord-014516-r59usk02 577 30 status status NN cord-014516-r59usk02 577 31 . . . cord-014516-r59usk02 578 1 Females female NNS cord-014516-r59usk02 578 2 had have VBD cord-014516-r59usk02 578 3 a a DT cord-014516-r59usk02 578 4 significantly significantly RB cord-014516-r59usk02 578 5 higher high JJR cord-014516-r59usk02 578 6 prevalence prevalence NN cord-014516-r59usk02 578 7 of of IN cord-014516-r59usk02 578 8 LASM LASM NNP cord-014516-r59usk02 578 9 than than IN cord-014516-r59usk02 578 10 males male NNS cord-014516-r59usk02 578 11 ( ( -LRB- cord-014516-r59usk02 578 12 36 36 CD cord-014516-r59usk02 578 13 % % NN cord-014516-r59usk02 578 14 vs. vs. IN cord-014516-r59usk02 578 15 21.8 21.8 CD cord-014516-r59usk02 578 16 % % NN cord-014516-r59usk02 578 17 , , , cord-014516-r59usk02 578 18 p p NN cord-014516-r59usk02 578 19 = = SYM cord-014516-r59usk02 578 20 0.046 0.046 CD cord-014516-r59usk02 578 21 ) ) -RRB- cord-014516-r59usk02 578 22 . . . cord-014516-r59usk02 579 1 Maltese maltese JJ cord-014516-r59usk02 579 2 dogs dog NNS cord-014516-r59usk02 579 3 in in IN cord-014516-r59usk02 579 4 Taiwan Taiwan NNP cord-014516-r59usk02 579 5 have have VBP cord-014516-r59usk02 579 6 a a DT cord-014516-r59usk02 579 7 very very RB cord-014516-r59usk02 579 8 high high JJ cord-014516-r59usk02 579 9 prevalence prevalence NN cord-014516-r59usk02 579 10 and and CC cord-014516-r59usk02 579 11 an an DT cord-014516-r59usk02 579 12 early early JJ cord-014516-r59usk02 579 13 development development NN cord-014516-r59usk02 579 14 of of IN cord-014516-r59usk02 579 15 MVD MVD NNP cord-014516-r59usk02 579 16 as as IN cord-014516-r59usk02 579 17 compared compare VBN cord-014516-r59usk02 579 18 to to IN cord-014516-r59usk02 579 19 other other JJ cord-014516-r59usk02 579 20 small small JJ cord-014516-r59usk02 579 21 breed breed NN cord-014516-r59usk02 579 22 dogs dog NNS cord-014516-r59usk02 579 23 , , , cord-014516-r59usk02 579 24 similar similar JJ cord-014516-r59usk02 579 25 to to IN cord-014516-r59usk02 579 26 MVD MVD NNP cord-014516-r59usk02 579 27 in in IN cord-014516-r59usk02 579 28 CKCS CKCS NNP cord-014516-r59usk02 579 29 in in IN cord-014516-r59usk02 579 30 other other JJ cord-014516-r59usk02 579 31 countries country NNS cord-014516-r59usk02 579 32 . . . cord-014516-r59usk02 580 1 Since since IN cord-014516-r59usk02 580 2 we -PRON- PRP cord-014516-r59usk02 580 3 only only RB cord-014516-r59usk02 580 4 recruited recruit VBD cord-014516-r59usk02 580 5 asymptomatic asymptomatic JJ cord-014516-r59usk02 580 6 Dogs Dogs NNP cord-014516-r59usk02 580 7 , , , cord-014516-r59usk02 580 8 this this DT cord-014516-r59usk02 580 9 study study NN cord-014516-r59usk02 580 10 may may MD cord-014516-r59usk02 580 11 underestimate underestimate VB cord-014516-r59usk02 580 12 the the DT cord-014516-r59usk02 580 13 prevalence prevalence NN cord-014516-r59usk02 580 14 of of IN cord-014516-r59usk02 580 15 MVD MVD NNP cord-014516-r59usk02 580 16 in in IN cord-014516-r59usk02 580 17 the the DT cord-014516-r59usk02 580 18 whole whole JJ cord-014516-r59usk02 580 19 Maltese maltese JJ cord-014516-r59usk02 580 20 population population NN cord-014516-r59usk02 580 21 . . . cord-014516-r59usk02 581 1 To to IN cord-014516-r59usk02 581 2 our -PRON- PRP$ cord-014516-r59usk02 581 3 knowledge knowledge NN cord-014516-r59usk02 581 4 , , , cord-014516-r59usk02 581 5 this this DT cord-014516-r59usk02 581 6 is be VBZ cord-014516-r59usk02 581 7 the the DT cord-014516-r59usk02 581 8 first first JJ cord-014516-r59usk02 581 9 report report NN cord-014516-r59usk02 581 10 to to TO cord-014516-r59usk02 581 11 document document VB cord-014516-r59usk02 581 12 the the DT cord-014516-r59usk02 581 13 high high JJ cord-014516-r59usk02 581 14 prevalence prevalence NN cord-014516-r59usk02 581 15 of of IN cord-014516-r59usk02 581 16 MVD MVD NNP cord-014516-r59usk02 581 17 in in IN cord-014516-r59usk02 581 18 Taiwanese taiwanese JJ cord-014516-r59usk02 581 19 Maltese Maltese NNP cord-014516-r59usk02 581 20 . . . cord-014516-r59usk02 582 1 The the DT cord-014516-r59usk02 582 2 Maltese Maltese NNP cord-014516-r59usk02 582 3 may may MD cord-014516-r59usk02 582 4 be be VB cord-014516-r59usk02 582 5 a a DT cord-014516-r59usk02 582 6 new new JJ cord-014516-r59usk02 582 7 canine canine JJ cord-014516-r59usk02 582 8 model model NN cord-014516-r59usk02 582 9 for for IN cord-014516-r59usk02 582 10 genetic genetic JJ cord-014516-r59usk02 582 11 , , , cord-014516-r59usk02 582 12 pathology pathology NN cord-014516-r59usk02 582 13 , , , cord-014516-r59usk02 582 14 and and CC cord-014516-r59usk02 582 15 natural natural JJ cord-014516-r59usk02 582 16 history history NN cord-014516-r59usk02 582 17 studies study NNS cord-014516-r59usk02 582 18 in in IN cord-014516-r59usk02 582 19 MVD MVD NNP cord-014516-r59usk02 582 20 . . . cord-014516-r59usk02 583 1 Boehringer Boehringer NNP cord-014516-r59usk02 583 2 - - HYPH cord-014516-r59usk02 583 3 Ingelheim Ingelheim NNP cord-014516-r59usk02 583 4 sponsored sponsor VBD cord-014516-r59usk02 583 5 the the DT cord-014516-r59usk02 583 6 author author NN cord-014516-r59usk02 583 7 's 's POS cord-014516-r59usk02 583 8 accommodation accommodation NN cord-014516-r59usk02 583 9 costs cost NNS cord-014516-r59usk02 583 10 for for IN cord-014516-r59usk02 583 11 this this DT cord-014516-r59usk02 583 12 congress congress NNP cord-014516-r59usk02 583 13 . . . cord-014516-r59usk02 584 1 ESVC ESVC NNP cord-014516-r59usk02 584 2 - - HYPH cord-014516-r59usk02 584 3 O-20 O-20 NNP cord-014516-r59usk02 584 4 CARDIORENAL CARDIORENAL NNP cord-014516-r59usk02 584 5 SYNDROME syndrome NN cord-014516-r59usk02 585 1 IN in IN cord-014516-r59usk02 585 2 DOGS dog NNS cord-014516-r59usk02 585 3 WITH with IN cord-014516-r59usk02 585 4 CHRONIC chronic NN cord-014516-r59usk02 585 5 VALVULAR VALVULAR NNP cord-014516-r59usk02 585 6 HEART heart NN cord-014516-r59usk02 585 7 DISEASE disease NN cord-014516-r59usk02 585 8 : : : cord-014516-r59usk02 585 9 A a DT cord-014516-r59usk02 585 10 RETROSPECTIVE RETROSPECTIVE NNP cord-014516-r59usk02 585 11 STUDY study NN cord-014516-r59usk02 585 12 . . . cord-014516-r59usk02 586 1 E. E. NNP cord-014516-r59usk02 586 2 Martinelli Martinelli NNP cord-014516-r59usk02 586 3 1 1 CD cord-014516-r59usk02 586 4 , , , cord-014516-r59usk02 586 5 P. P. NNP cord-014516-r59usk02 586 6 Scarpa Scarpa NNP cord-014516-r59usk02 586 7 2 2 CD cord-014516-r59usk02 586 8 , , , cord-014516-r59usk02 586 9 C. C. NNP cord-014516-r59usk02 586 10 Quintavalla Quintavalla NNP cord-014516-r59usk02 586 11 1 1 CD cord-014516-r59usk02 586 12 , , , cord-014516-r59usk02 586 13 C. C. NNP cord-014516-r59usk02 586 14 Locatelli Locatelli NNP cord-014516-r59usk02 586 15 2 2 CD cord-014516-r59usk02 586 16 , , , cord-014516-r59usk02 586 17 P. P. NNP cord-014516-r59usk02 586 18 Brambilla Brambilla NNP cord-014516-r59usk02 586 19 2 2 CD cord-014516-r59usk02 586 20 . . . cord-014516-r59usk02 587 1 1 1 CD cord-014516-r59usk02 587 2 University University NNP cord-014516-r59usk02 587 3 of of IN cord-014516-r59usk02 587 4 Parma Parma NNP cord-014516-r59usk02 587 5 , , , cord-014516-r59usk02 587 6 Parma Parma NNP cord-014516-r59usk02 587 7 , , , cord-014516-r59usk02 587 8 Italy Italy NNP cord-014516-r59usk02 587 9 , , , cord-014516-r59usk02 587 10 2 2 CD cord-014516-r59usk02 587 11 University University NNP cord-014516-r59usk02 587 12 of of IN cord-014516-r59usk02 587 13 Milan Milan NNP cord-014516-r59usk02 587 14 , , , cord-014516-r59usk02 587 15 Milan Milan NNP cord-014516-r59usk02 587 16 , , , cord-014516-r59usk02 587 17 Italy Italy NNP cord-014516-r59usk02 588 1 In in IN cord-014516-r59usk02 588 2 human human JJ cord-014516-r59usk02 588 3 medicine medicine NN cord-014516-r59usk02 588 4 , , , cord-014516-r59usk02 588 5 primary primary JJ cord-014516-r59usk02 588 6 disorders disorder NNS cord-014516-r59usk02 588 7 of of IN cord-014516-r59usk02 588 8 the the DT cord-014516-r59usk02 588 9 heart heart NN cord-014516-r59usk02 588 10 often often RB cord-014516-r59usk02 588 11 result result VBP cord-014516-r59usk02 588 12 in in IN cord-014516-r59usk02 588 13 secondary secondary JJ cord-014516-r59usk02 588 14 dysfunction dysfunction NN cord-014516-r59usk02 588 15 or or CC cord-014516-r59usk02 588 16 injury injury NN cord-014516-r59usk02 588 17 to to IN cord-014516-r59usk02 588 18 the the DT cord-014516-r59usk02 588 19 kidneys kidney NNS cord-014516-r59usk02 588 20 . . . cord-014516-r59usk02 589 1 The the DT cord-014516-r59usk02 589 2 coexistence coexistence NN cord-014516-r59usk02 589 3 of of IN cord-014516-r59usk02 589 4 the the DT cord-014516-r59usk02 589 5 two two CD cord-014516-r59usk02 589 6 problems problem NNS cord-014516-r59usk02 589 7 in in IN cord-014516-r59usk02 589 8 the the DT cord-014516-r59usk02 589 9 same same JJ cord-014516-r59usk02 589 10 patient patient NN cord-014516-r59usk02 589 11 is be VBZ cord-014516-r59usk02 589 12 referred refer VBN cord-014516-r59usk02 589 13 as as IN cord-014516-r59usk02 589 14 cardiorenal cardiorenal JJ cord-014516-r59usk02 589 15 syndrome syndrome NN cord-014516-r59usk02 589 16 ( ( -LRB- cord-014516-r59usk02 589 17 CRS CRS NNP cord-014516-r59usk02 589 18 ) ) -RRB- cord-014516-r59usk02 589 19 . . . cord-014516-r59usk02 590 1 Just just RB cord-014516-r59usk02 590 2 little little JJ cord-014516-r59usk02 590 3 information information NN cord-014516-r59usk02 590 4 about about IN cord-014516-r59usk02 590 5 CRS CRS NNP cord-014516-r59usk02 590 6 is be VBZ cord-014516-r59usk02 590 7 available available JJ cord-014516-r59usk02 590 8 in in IN cord-014516-r59usk02 590 9 veterinary veterinary JJ cord-014516-r59usk02 590 10 medicine medicine NN cord-014516-r59usk02 590 11 . . . cord-014516-r59usk02 591 1 The the DT cord-014516-r59usk02 591 2 aim aim NN cord-014516-r59usk02 591 3 of of IN cord-014516-r59usk02 591 4 this this DT cord-014516-r59usk02 591 5 study study NN cord-014516-r59usk02 591 6 was be VBD cord-014516-r59usk02 591 7 to to TO cord-014516-r59usk02 591 8 define define VB cord-014516-r59usk02 591 9 the the DT cord-014516-r59usk02 591 10 prevalence prevalence NN cord-014516-r59usk02 591 11 of of IN cord-014516-r59usk02 591 12 chronic chronic JJ cord-014516-r59usk02 591 13 kidney kidney NN cord-014516-r59usk02 591 14 disease disease NN cord-014516-r59usk02 591 15 ( ( -LRB- cord-014516-r59usk02 591 16 CKD CKD NNP cord-014516-r59usk02 591 17 ) ) -RRB- cord-014516-r59usk02 591 18 complicating complicate VBG cord-014516-r59usk02 591 19 chronic chronic JJ cord-014516-r59usk02 591 20 valvular valvular JJ cord-014516-r59usk02 591 21 heart heart NN cord-014516-r59usk02 591 22 disease disease NN cord-014516-r59usk02 591 23 ( ( -LRB- cord-014516-r59usk02 591 24 CVHD CVHD NNP cord-014516-r59usk02 591 25 ) ) -RRB- cord-014516-r59usk02 591 26 in in IN cord-014516-r59usk02 591 27 dogs dog NNS cord-014516-r59usk02 591 28 and and CC cord-014516-r59usk02 591 29 to to TO cord-014516-r59usk02 591 30 investigate investigate VB cord-014516-r59usk02 591 31 the the DT cord-014516-r59usk02 591 32 relationship relationship NN cord-014516-r59usk02 591 33 between between IN cord-014516-r59usk02 591 34 class class NN cord-014516-r59usk02 591 35 of of IN cord-014516-r59usk02 591 36 cardiac cardiac JJ cord-014516-r59usk02 591 37 insufficiency insufficiency NN cord-014516-r59usk02 591 38 ( ( -LRB- cord-014516-r59usk02 591 39 ACVIM ACVIM NNP cord-014516-r59usk02 591 40 ) ) -RRB- cord-014516-r59usk02 591 41 and and CC cord-014516-r59usk02 591 42 class class NN cord-014516-r59usk02 591 43 of of IN cord-014516-r59usk02 591 44 renal renal JJ cord-014516-r59usk02 591 45 insufficiency insufficiency NN cord-014516-r59usk02 591 46 ( ( -LRB- cord-014516-r59usk02 591 47 IRIS IRIS NNP cord-014516-r59usk02 591 48 ) ) -RRB- cord-014516-r59usk02 591 49 . . . cord-014516-r59usk02 592 1 Medical medical JJ cord-014516-r59usk02 592 2 records record NNS cord-014516-r59usk02 592 3 of of IN cord-014516-r59usk02 592 4 dogs dog NNS cord-014516-r59usk02 592 5 presented present VBN cord-014516-r59usk02 592 6 at at IN cord-014516-r59usk02 592 7 the the DT cord-014516-r59usk02 592 8 Cardiology Cardiology NNP cord-014516-r59usk02 592 9 Service Service NNP cord-014516-r59usk02 592 10 of of IN cord-014516-r59usk02 592 11 the the DT cord-014516-r59usk02 592 12 Department Department NNP cord-014516-r59usk02 592 13 of of IN cord-014516-r59usk02 592 14 Veterinary Veterinary NNP cord-014516-r59usk02 592 15 Science Science NNP cord-014516-r59usk02 592 16 and and CC cord-014516-r59usk02 592 17 Public Public NNP cord-014516-r59usk02 592 18 Health Health NNP cord-014516-r59usk02 592 19 , , , cord-014516-r59usk02 592 20 University University NNP cord-014516-r59usk02 592 21 of of IN cord-014516-r59usk02 592 22 Milan Milan NNP cord-014516-r59usk02 592 23 , , , cord-014516-r59usk02 592 24 between between IN cord-014516-r59usk02 592 25 January January NNP cord-014516-r59usk02 592 26 2003 2003 CD cord-014516-r59usk02 592 27 and and CC cord-014516-r59usk02 592 28 December December NNP cord-014516-r59usk02 592 29 2012 2012 CD cord-014516-r59usk02 592 30 were be VBD cord-014516-r59usk02 592 31 retrospectively retrospectively RB cord-014516-r59usk02 592 32 evaluated evaluate VBN cord-014516-r59usk02 592 33 . . . cord-014516-r59usk02 593 1 Dogs dog NNS cord-014516-r59usk02 593 2 with with IN cord-014516-r59usk02 593 3 a a DT cord-014516-r59usk02 593 4 complete complete JJ cord-014516-r59usk02 593 5 physical physical JJ cord-014516-r59usk02 593 6 examination examination NN cord-014516-r59usk02 593 7 , , , cord-014516-r59usk02 593 8 thoracic thoracic JJ cord-014516-r59usk02 593 9 radiographs radiograph NNS cord-014516-r59usk02 593 10 , , , cord-014516-r59usk02 593 11 a a DT cord-014516-r59usk02 593 12 CVHD CVHD NNP cord-014516-r59usk02 593 13 diagnosis diagnosis NN cord-014516-r59usk02 593 14 based base VBN cord-014516-r59usk02 593 15 on on IN cord-014516-r59usk02 593 16 echocardiographic echocardiographic JJ cord-014516-r59usk02 593 17 examination examination NN cord-014516-r59usk02 593 18 , , , cord-014516-r59usk02 593 19 and and CC cord-014516-r59usk02 593 20 a a DT cord-014516-r59usk02 593 21 serum serum NN cord-014516-r59usk02 593 22 biochemical biochemical JJ cord-014516-r59usk02 593 23 panel panel NN cord-014516-r59usk02 593 24 , , , cord-014516-r59usk02 593 25 including include VBG cord-014516-r59usk02 593 26 assessment assessment NN cord-014516-r59usk02 593 27 of of IN cord-014516-r59usk02 593 28 serum serum NN cord-014516-r59usk02 593 29 creatinine creatinine NN cord-014516-r59usk02 593 30 ( ( -LRB- cord-014516-r59usk02 593 31 sCr sCr NNP cord-014516-r59usk02 593 32 ) ) -RRB- cord-014516-r59usk02 593 33 and and CC cord-014516-r59usk02 593 34 serum serum NN cord-014516-r59usk02 593 35 urea urea NN cord-014516-r59usk02 593 36 ( ( -LRB- cord-014516-r59usk02 593 37 BUN BUN NNP cord-014516-r59usk02 593 38 ) ) -RRB- cord-014516-r59usk02 593 39 , , , cord-014516-r59usk02 593 40 were be VBD cord-014516-r59usk02 593 41 included include VBN cord-014516-r59usk02 593 42 in in IN cord-014516-r59usk02 593 43 the the DT cord-014516-r59usk02 593 44 study study NN cord-014516-r59usk02 593 45 . . . cord-014516-r59usk02 594 1 Dogs dog NNS cord-014516-r59usk02 594 2 with with IN cord-014516-r59usk02 594 3 other other JJ cord-014516-r59usk02 594 4 heart heart NN cord-014516-r59usk02 594 5 disease disease NN cord-014516-r59usk02 594 6 , , , cord-014516-r59usk02 594 7 neoplasm neoplasm NN cord-014516-r59usk02 594 8 or or CC cord-014516-r59usk02 594 9 systemic systemic JJ cord-014516-r59usk02 594 10 diseases disease NNS cord-014516-r59usk02 594 11 were be VBD cord-014516-r59usk02 594 12 not not RB cord-014516-r59usk02 594 13 included include VBN cord-014516-r59usk02 594 14 in in IN cord-014516-r59usk02 594 15 the the DT cord-014516-r59usk02 594 16 study study NN cord-014516-r59usk02 594 17 . . . cord-014516-r59usk02 595 1 One one CD cord-014516-r59usk02 595 2 hundred hundred CD cord-014516-r59usk02 595 3 eighteen eighteen CD cord-014516-r59usk02 595 4 dogs dog NNS cord-014516-r59usk02 595 5 of of IN cord-014516-r59usk02 595 6 both both DT cord-014516-r59usk02 595 7 genders gender NNS cord-014516-r59usk02 595 8 ( ( -LRB- cord-014516-r59usk02 595 9 73 73 CD cord-014516-r59usk02 595 10 males male NNS cord-014516-r59usk02 595 11 and and CC cord-014516-r59usk02 595 12 45 45 CD cord-014516-r59usk02 595 13 females female NNS cord-014516-r59usk02 595 14 ) ) -RRB- cord-014516-r59usk02 595 15 , , , cord-014516-r59usk02 595 16 5 5 CD cord-014516-r59usk02 595 17 to to TO cord-014516-r59usk02 595 18 18 18 CD cord-014516-r59usk02 595 19 years year NNS cord-014516-r59usk02 595 20 of of IN cord-014516-r59usk02 595 21 age age NN cord-014516-r59usk02 595 22 ( ( -LRB- cord-014516-r59usk02 595 23 11.64 11.64 CD cord-014516-r59usk02 595 24 AE AE NNP cord-014516-r59usk02 595 25 2.66 2.66 CD cord-014516-r59usk02 595 26 years year NNS cord-014516-r59usk02 595 27 ) ) -RRB- cord-014516-r59usk02 595 28 , , , cord-014516-r59usk02 595 29 3 3 CD cord-014516-r59usk02 595 30 to to TO cord-014516-r59usk02 595 31 48 48 CD cord-014516-r59usk02 595 32 kg kg NNS cord-014516-r59usk02 595 33 of of IN cord-014516-r59usk02 595 34 bodyweight bodyweight NN cord-014516-r59usk02 595 35 ( ( -LRB- cord-014516-r59usk02 595 36 11.38 11.38 CD cord-014516-r59usk02 595 37 AE AE NNP cord-014516-r59usk02 595 38 8.84 8.84 CD cord-014516-r59usk02 595 39 kg kg NNS cord-014516-r59usk02 595 40 ) ) -RRB- cord-014516-r59usk02 595 41 fulfilled fulfil VBD cord-014516-r59usk02 595 42 the the DT cord-014516-r59usk02 595 43 inclusion inclusion NN cord-014516-r59usk02 595 44 criteria criterion NNS cord-014516-r59usk02 595 45 . . . cord-014516-r59usk02 596 1 The the DT cord-014516-r59usk02 596 2 20 20 CD cord-014516-r59usk02 596 3 % % NN cord-014516-r59usk02 596 4 of of IN cord-014516-r59usk02 596 5 males male NNS cord-014516-r59usk02 596 6 and and CC cord-014516-r59usk02 596 7 the the DT cord-014516-r59usk02 596 8 37 37 CD cord-014516-r59usk02 596 9 % % NN cord-014516-r59usk02 596 10 of of IN cord-014516-r59usk02 596 11 females female NNS cord-014516-r59usk02 596 12 were be VBD cord-014516-r59usk02 596 13 neutered neuter VBN cord-014516-r59usk02 596 14 . . . cord-014516-r59usk02 597 1 The the DT cord-014516-r59usk02 597 2 most most RBS cord-014516-r59usk02 597 3 represented represent VBN cord-014516-r59usk02 597 4 breeds breed NNS cord-014516-r59usk02 597 5 were be VBD cord-014516-r59usk02 597 6 mongrel mongrel JJ cord-014516-r59usk02 597 7 ( ( -LRB- cord-014516-r59usk02 597 8 44 44 CD cord-014516-r59usk02 597 9 % % NN cord-014516-r59usk02 597 10 ) ) -RRB- cord-014516-r59usk02 597 11 , , , cord-014516-r59usk02 597 12 miniature miniature JJ cord-014516-r59usk02 597 13 Poodle Poodle NNP cord-014516-r59usk02 597 14 ( ( -LRB- cord-014516-r59usk02 597 15 9.32 9.32 CD cord-014516-r59usk02 597 16 % % NN cord-014516-r59usk02 597 17 ) ) -RRB- cord-014516-r59usk02 597 18 , , , cord-014516-r59usk02 597 19 York York NNP cord-014516-r59usk02 597 20 Shire Shire NNP cord-014516-r59usk02 597 21 Terrier Terrier NNP cord-014516-r59usk02 597 22 ( ( -LRB- cord-014516-r59usk02 597 23 8.5 8.5 CD cord-014516-r59usk02 597 24 % % NN cord-014516-r59usk02 597 25 ) ) -RRB- cord-014516-r59usk02 597 26 , , , cord-014516-r59usk02 597 27 Shih Shih NNP cord-014516-r59usk02 597 28 -Tzu -Tzu : cord-014516-r59usk02 597 29 ( ( -LRB- cord-014516-r59usk02 597 30 4.24 4.24 CD cord-014516-r59usk02 597 31 % % NN cord-014516-r59usk02 597 32 ) ) -RRB- cord-014516-r59usk02 597 33 , , , cord-014516-r59usk02 597 34 Pinscher Pinscher NNP cord-014516-r59usk02 597 35 ( ( -LRB- cord-014516-r59usk02 597 36 4.24 4.24 CD cord-014516-r59usk02 597 37 % % NN cord-014516-r59usk02 597 38 ) ) -RRB- cord-014516-r59usk02 597 39 and and CC cord-014516-r59usk02 597 40 Dachshund Dachshund NNP cord-014516-r59usk02 597 41 ( ( -LRB- cord-014516-r59usk02 597 42 3.38 3.38 CD cord-014516-r59usk02 597 43 % % NN cord-014516-r59usk02 597 44 ) ) -RRB- cord-014516-r59usk02 597 45 . . . cord-014516-r59usk02 598 1 Dogs dog NNS cord-014516-r59usk02 598 2 were be VBD cord-014516-r59usk02 598 3 classified classify VBN cord-014516-r59usk02 598 4 as as IN cord-014516-r59usk02 598 5 follow follow NN cord-014516-r59usk02 598 6 : : : cord-014516-r59usk02 598 7 0 0 CD cord-014516-r59usk02 598 8 % % NN cord-014516-r59usk02 598 9 ACVIM ACVIM NNP cord-014516-r59usk02 598 10 A a NN cord-014516-r59usk02 598 11 , , , cord-014516-r59usk02 598 12 23 23 CD cord-014516-r59usk02 598 13 % % NN cord-014516-r59usk02 598 14 ACVIM acvim NN cord-014516-r59usk02 598 15 B1 b1 NN cord-014516-r59usk02 598 16 , , , cord-014516-r59usk02 598 17 9 9 CD cord-014516-r59usk02 598 18 % % NN cord-014516-r59usk02 598 19 ACVIM ACVIM NNP cord-014516-r59usk02 598 20 B2 b2 NN cord-014516-r59usk02 598 21 , , , cord-014516-r59usk02 598 22 59 59 CD cord-014516-r59usk02 598 23 % % NN cord-014516-r59usk02 598 24 ACVIM ACVIM NNP cord-014516-r59usk02 598 25 C c NN cord-014516-r59usk02 598 26 and and CC cord-014516-r59usk02 598 27 9 9 CD cord-014516-r59usk02 598 28 % % NN cord-014516-r59usk02 598 29 ACVIM ACVIM NNP cord-014516-r59usk02 598 30 D. D. NNP cord-014516-r59usk02 599 1 While while IN cord-014516-r59usk02 599 2 the the DT cord-014516-r59usk02 599 3 73 73 CD cord-014516-r59usk02 599 4 % % NN cord-014516-r59usk02 599 5 of of IN cord-014516-r59usk02 599 6 the the DT cord-014516-r59usk02 599 7 dogs dog NNS cord-014516-r59usk02 599 8 were be VBD cord-014516-r59usk02 599 9 normoazotemic normoazotemic JJ cord-014516-r59usk02 599 10 ( ( -LRB- cord-014516-r59usk02 599 11 sCr scr XX cord-014516-r59usk02 599 12 < < XX cord-014516-r59usk02 599 13 1,4 1,4 CD cord-014516-r59usk02 599 14 mg mg NNP cord-014516-r59usk02 599 15 / / SYM cord-014516-r59usk02 599 16 dl dl NNP cord-014516-r59usk02 599 17 ) ) -RRB- cord-014516-r59usk02 599 18 , , , cord-014516-r59usk02 599 19 16 16 CD cord-014516-r59usk02 599 20 % % NN cord-014516-r59usk02 599 21 were be VBD cord-014516-r59usk02 599 22 staged stage VBN cord-014516-r59usk02 599 23 in in IN cord-014516-r59usk02 599 24 IRIS IRIS NNP cord-014516-r59usk02 599 25 2 2 CD cord-014516-r59usk02 599 26 , , , cord-014516-r59usk02 599 27 11 11 CD cord-014516-r59usk02 599 28 % % NN cord-014516-r59usk02 599 29 in in IN cord-014516-r59usk02 599 30 IRIS IRIS NNP cord-014516-r59usk02 599 31 3 3 CD cord-014516-r59usk02 599 32 and and CC cord-014516-r59usk02 599 33 0%in 0%in CD cord-014516-r59usk02 599 34 IRIS IRIS NNP cord-014516-r59usk02 599 35 4 4 CD cord-014516-r59usk02 599 36 . . . cord-014516-r59usk02 600 1 Statistical statistical JJ cord-014516-r59usk02 600 2 analysis analysis NN cord-014516-r59usk02 600 3 was be VBD cord-014516-r59usk02 600 4 performed perform VBN cord-014516-r59usk02 600 5 using use VBG cord-014516-r59usk02 600 6 JMP JMP NNP cord-014516-r59usk02 600 7 7.0 7.0 NNP cord-014516-r59usk02 600 8 ( ( -LRB- cord-014516-r59usk02 600 9 SAS SAS NNP cord-014516-r59usk02 600 10 Institute Institute NNP cord-014516-r59usk02 600 11 Inc. Inc. NNP cord-014516-r59usk02 600 12 ) ) -RRB- cord-014516-r59usk02 600 13 . . . cord-014516-r59usk02 601 1 A a DT cord-014516-r59usk02 601 2 p p NN cord-014516-r59usk02 601 3 value value NN cord-014516-r59usk02 601 4 < < XX cord-014516-r59usk02 601 5 0,05 0,05 NNP cord-014516-r59usk02 601 6 was be VBD cord-014516-r59usk02 601 7 considered consider VBN cord-014516-r59usk02 601 8 significant significant JJ cord-014516-r59usk02 601 9 . . . cord-014516-r59usk02 602 1 The the DT cord-014516-r59usk02 602 2 prevalence prevalence NN cord-014516-r59usk02 602 3 of of IN cord-014516-r59usk02 602 4 CKD CKD NNP cord-014516-r59usk02 602 5 associated associate VBN cord-014516-r59usk02 602 6 with with IN cord-014516-r59usk02 602 7 azotemia azotemia NN cord-014516-r59usk02 602 8 in in IN cord-014516-r59usk02 602 9 dogs dog NNS cord-014516-r59usk02 602 10 affected affect VBN cord-014516-r59usk02 602 11 by by IN cord-014516-r59usk02 602 12 CVHD CVHD NNP cord-014516-r59usk02 602 13 was be VBD cord-014516-r59usk02 602 14 27 27 CD cord-014516-r59usk02 602 15 % % NN cord-014516-r59usk02 602 16 . . . cord-014516-r59usk02 603 1 There there EX cord-014516-r59usk02 603 2 was be VBD cord-014516-r59usk02 603 3 a a DT cord-014516-r59usk02 603 4 statistically statistically RB cord-014516-r59usk02 603 5 significant significant JJ cord-014516-r59usk02 603 6 direct direct JJ cord-014516-r59usk02 603 7 correlation correlation NN cord-014516-r59usk02 603 8 between between IN cord-014516-r59usk02 603 9 ACVIM ACVIM NNP cord-014516-r59usk02 603 10 and and CC cord-014516-r59usk02 603 11 IRIS IRIS NNP cord-014516-r59usk02 603 12 class class NN cord-014516-r59usk02 604 1 ( ( -LRB- cord-014516-r59usk02 604 2 Pearson Pearson NNP cord-014516-r59usk02 604 3 test test NN cord-014516-r59usk02 604 4 p p NN cord-014516-r59usk02 604 5 = = SYM cord-014516-r59usk02 604 6 0.0114 0.0114 CD cord-014516-r59usk02 604 7 ) ) -RRB- cord-014516-r59usk02 604 8 . . . cord-014516-r59usk02 605 1 Unexpectedly unexpectedly RB cord-014516-r59usk02 605 2 , , , cord-014516-r59usk02 605 3 the the DT cord-014516-r59usk02 605 4 58 58 CD cord-014516-r59usk02 605 5 % % NN cord-014516-r59usk02 605 6 of of IN cord-014516-r59usk02 605 7 dogs dog NNS cord-014516-r59usk02 605 8 receiving receive VBG cord-014516-r59usk02 605 9 drugs drug NNS cord-014516-r59usk02 605 10 for for IN cord-014516-r59usk02 605 11 medical medical JJ cord-014516-r59usk02 605 12 management management NN cord-014516-r59usk02 605 13 of of IN cord-014516-r59usk02 605 14 heart heart NN cord-014516-r59usk02 605 15 failure failure NN cord-014516-r59usk02 605 16 ( ( -LRB- cord-014516-r59usk02 605 17 ACVIM ACVIM NNP cord-014516-r59usk02 605 18 class class NN cord-014516-r59usk02 605 19 C c NN cord-014516-r59usk02 605 20 and and CC cord-014516-r59usk02 605 21 D D NNP cord-014516-r59usk02 605 22 ) ) -RRB- cord-014516-r59usk02 605 23 were be VBD cord-014516-r59usk02 605 24 normoazotemic normoazotemic JJ cord-014516-r59usk02 605 25 . . . cord-014516-r59usk02 606 1 Despite despite IN cord-014516-r59usk02 606 2 a a DT cord-014516-r59usk02 606 3 definite definite JJ cord-014516-r59usk02 606 4 conclusion conclusion NN cord-014516-r59usk02 606 5 about about IN cord-014516-r59usk02 606 6 the the DT cord-014516-r59usk02 606 7 role role NN cord-014516-r59usk02 606 8 of of IN cord-014516-r59usk02 606 9 CVHD CVHD NNP cord-014516-r59usk02 606 10 on on IN cord-014516-r59usk02 606 11 the the DT cord-014516-r59usk02 606 12 induction induction NN cord-014516-r59usk02 606 13 and/or and/or CC cord-014516-r59usk02 606 14 progression progression NN cord-014516-r59usk02 606 15 of of IN cord-014516-r59usk02 606 16 CKD CKD NNP cord-014516-r59usk02 606 17 can can MD cord-014516-r59usk02 606 18 not not RB cord-014516-r59usk02 606 19 be be VB cord-014516-r59usk02 606 20 drawn draw VBN cord-014516-r59usk02 606 21 from from IN cord-014516-r59usk02 606 22 this this DT cord-014516-r59usk02 606 23 cross cross JJ cord-014516-r59usk02 606 24 - - JJ cord-014516-r59usk02 606 25 sectional sectional JJ cord-014516-r59usk02 606 26 study study NN cord-014516-r59usk02 606 27 , , , cord-014516-r59usk02 606 28 these these DT cord-014516-r59usk02 606 29 results result NNS cord-014516-r59usk02 606 30 suggest suggest VBP cord-014516-r59usk02 606 31 that that IN cord-014516-r59usk02 606 32 there there EX cord-014516-r59usk02 606 33 is be VBZ cord-014516-r59usk02 606 34 a a DT cord-014516-r59usk02 606 35 direct direct JJ cord-014516-r59usk02 606 36 correlation correlation NN cord-014516-r59usk02 606 37 between between IN cord-014516-r59usk02 606 38 the the DT cord-014516-r59usk02 606 39 severity severity NN cord-014516-r59usk02 606 40 of of IN cord-014516-r59usk02 606 41 CKD CKD NNP cord-014516-r59usk02 606 42 and and CC cord-014516-r59usk02 606 43 CVHD CVHD NNP cord-014516-r59usk02 606 44 . . . cord-014516-r59usk02 607 1 No no DT cord-014516-r59usk02 607 2 conflicts conflict NNS cord-014516-r59usk02 607 3 of of IN cord-014516-r59usk02 607 4 interest interest NN cord-014516-r59usk02 607 5 reported report VBN cord-014516-r59usk02 607 6 . . . cord-014516-r59usk02 608 1 There there EX cord-014516-r59usk02 608 2 is be VBZ cord-014516-r59usk02 608 3 growing grow VBG cord-014516-r59usk02 608 4 evidence evidence NN cord-014516-r59usk02 608 5 of of IN cord-014516-r59usk02 608 6 breed breed NN cord-014516-r59usk02 608 7 differences difference NNS cord-014516-r59usk02 608 8 in in IN cord-014516-r59usk02 608 9 concentrations concentration NNS cord-014516-r59usk02 608 10 of of IN cord-014516-r59usk02 608 11 several several JJ cord-014516-r59usk02 608 12 blood blood NN cord-014516-r59usk02 608 13 variables variable NNS cord-014516-r59usk02 608 14 in in IN cord-014516-r59usk02 608 15 dogs dog NNS cord-014516-r59usk02 608 16 . . . cord-014516-r59usk02 609 1 The the DT cord-014516-r59usk02 609 2 aim aim NN cord-014516-r59usk02 609 3 of of IN cord-014516-r59usk02 609 4 the the DT cord-014516-r59usk02 609 5 study study NN cord-014516-r59usk02 609 6 was be VBD cord-014516-r59usk02 609 7 to to TO cord-014516-r59usk02 609 8 investigate investigate VB cord-014516-r59usk02 609 9 breed breed NN cord-014516-r59usk02 609 10 differences difference NNS cord-014516-r59usk02 609 11 in in IN cord-014516-r59usk02 609 12 plasma plasma NN cord-014516-r59usk02 609 13 concentrations concentration NNS cord-014516-r59usk02 609 14 of of IN cord-014516-r59usk02 609 15 components component NNS cord-014516-r59usk02 609 16 of of IN cord-014516-r59usk02 609 17 the the DT cord-014516-r59usk02 609 18 renin renin NN cord-014516-r59usk02 609 19 - - HYPH cord-014516-r59usk02 609 20 angiotensin angiotensin NN cord-014516-r59usk02 609 21 - - HYPH cord-014516-r59usk02 609 22 aldosterone aldosterone NN cord-014516-r59usk02 609 23 system system NN cord-014516-r59usk02 609 24 ( ( -LRB- cord-014516-r59usk02 609 25 RAAS RAAS NNP cord-014516-r59usk02 609 26 ) ) -RRB- cord-014516-r59usk02 609 27 , , , cord-014516-r59usk02 609 28 endothelin-1 endothelin-1 NNP cord-014516-r59usk02 609 29 ( ( -LRB- cord-014516-r59usk02 609 30 ET-1 ET-1 NNP cord-014516-r59usk02 609 31 ) ) -RRB- cord-014516-r59usk02 610 1 and and CC cord-014516-r59usk02 610 2 serum serum NN cord-014516-r59usk02 610 3 cortisol cortisol NN cord-014516-r59usk02 610 4 concentration concentration NN cord-014516-r59usk02 610 5 in in IN cord-014516-r59usk02 610 6 healthy healthy JJ cord-014516-r59usk02 610 7 dogs dog NNS cord-014516-r59usk02 610 8 . . . cord-014516-r59usk02 611 1 535 535 CD cord-014516-r59usk02 611 2 healthy healthy JJ cord-014516-r59usk02 611 3 , , , cord-014516-r59usk02 611 4 privately privately RB cord-014516-r59usk02 611 5 - - HYPH cord-014516-r59usk02 611 6 owned own VBN cord-014516-r59usk02 611 7 dogs dog NNS cord-014516-r59usk02 611 8 of of IN cord-014516-r59usk02 611 9 nine nine CD cord-014516-r59usk02 611 10 breeds breed NNS cord-014516-r59usk02 611 11 were be VBD cord-014516-r59usk02 611 12 examined examine VBN cord-014516-r59usk02 611 13 at at IN cord-014516-r59usk02 611 14 five five CD cord-014516-r59usk02 611 15 centers center NNS cord-014516-r59usk02 611 16 as as IN cord-014516-r59usk02 611 17 part part NN cord-014516-r59usk02 611 18 of of IN cord-014516-r59usk02 611 19 the the DT cord-014516-r59usk02 611 20 European European NNP cord-014516-r59usk02 611 21 LUPA LUPA NNP cord-014516-r59usk02 611 22 - - HYPH cord-014516-r59usk02 611 23 project project NN cord-014516-r59usk02 611 24 . . . cord-014516-r59usk02 612 1 Absence absence NN cord-014516-r59usk02 612 2 of of IN cord-014516-r59usk02 612 3 cardiovascular cardiovascular JJ cord-014516-r59usk02 612 4 or or CC cord-014516-r59usk02 612 5 other other JJ cord-014516-r59usk02 612 6 clinically clinically RB cord-014516-r59usk02 612 7 relevant relevant JJ cord-014516-r59usk02 612 8 organrelated organrelate VBN cord-014516-r59usk02 612 9 or or CC cord-014516-r59usk02 612 10 systemic systemic JJ cord-014516-r59usk02 612 11 disease disease NN cord-014516-r59usk02 612 12 was be VBD cord-014516-r59usk02 612 13 ensured ensure VBN cord-014516-r59usk02 612 14 by by IN cord-014516-r59usk02 612 15 thorough thorough JJ cord-014516-r59usk02 612 16 clinical clinical JJ cord-014516-r59usk02 612 17 investigations investigation NNS cord-014516-r59usk02 612 18 . . . cord-014516-r59usk02 613 1 Plasma plasma NN cord-014516-r59usk02 613 2 concentrations concentration NNS cord-014516-r59usk02 613 3 of of IN cord-014516-r59usk02 613 4 ET-1 ET-1 NNP cord-014516-r59usk02 613 5 and and CC cord-014516-r59usk02 613 6 aldosterone aldosterone NN cord-014516-r59usk02 613 7 , , , cord-014516-r59usk02 613 8 renin renin NN cord-014516-r59usk02 613 9 activity activity NN cord-014516-r59usk02 613 10 , , , cord-014516-r59usk02 613 11 and and CC cord-014516-r59usk02 613 12 serum serum NN cord-014516-r59usk02 613 13 concentration concentration NN cord-014516-r59usk02 613 14 of of IN cord-014516-r59usk02 613 15 cortisol cortisol NN cord-014516-r59usk02 613 16 were be VBD cord-014516-r59usk02 613 17 measured measure VBN cord-014516-r59usk02 613 18 by by IN cord-014516-r59usk02 613 19 RIA RIA NNP cord-014516-r59usk02 613 20 or or CC cord-014516-r59usk02 613 21 ELISA ELISA NNP cord-014516-r59usk02 613 22 assays assay NNS cord-014516-r59usk02 613 23 . . . cord-014516-r59usk02 614 1 Overall overall JJ cord-014516-r59usk02 614 2 significant significant JJ cord-014516-r59usk02 614 3 breed breed NN cord-014516-r59usk02 614 4 differences difference NNS cord-014516-r59usk02 614 5 were be VBD cord-014516-r59usk02 614 6 found find VBN cord-014516-r59usk02 614 7 ( ( -LRB- cord-014516-r59usk02 614 8 P p NN cord-014516-r59usk02 614 9 < < XX cord-014516-r59usk02 614 10 0.0001 0.0001 CD cord-014516-r59usk02 614 11 for for IN cord-014516-r59usk02 614 12 all all DT cord-014516-r59usk02 614 13 4 4 CD cord-014516-r59usk02 614 14 variables variable NNS cord-014516-r59usk02 614 15 ) ) -RRB- cord-014516-r59usk02 614 16 . . . cord-014516-r59usk02 615 1 Bonferroni Bonferroni NNP cord-014516-r59usk02 615 2 - - HYPH cord-014516-r59usk02 615 3 corrected correct VBN cord-014516-r59usk02 615 4 pair pair NN cord-014516-r59usk02 615 5 - - HYPH cord-014516-r59usk02 615 6 wise wise JJ cord-014516-r59usk02 615 7 significant significant JJ cord-014516-r59usk02 615 8 differences difference NNS cord-014516-r59usk02 615 9 between between IN cord-014516-r59usk02 615 10 breeds breed NNS cord-014516-r59usk02 615 11 were be VBD cord-014516-r59usk02 615 12 found find VBN cord-014516-r59usk02 615 13 in in IN cord-014516-r59usk02 615 14 67 67 CD cord-014516-r59usk02 615 15 % % NN cord-014516-r59usk02 615 16 of of IN cord-014516-r59usk02 615 17 comparisons comparison NNS cord-014516-r59usk02 615 18 for for IN cord-014516-r59usk02 615 19 ET-1 ET-1 NNP cord-014516-r59usk02 615 20 , , , cord-014516-r59usk02 615 21 22 22 CD cord-014516-r59usk02 615 22 % % NN cord-014516-r59usk02 615 23 for for IN cord-014516-r59usk02 615 24 cortisol cortisol NN cord-014516-r59usk02 615 25 , , , cord-014516-r59usk02 615 26 19 19 CD cord-014516-r59usk02 615 27 % % NN cord-014516-r59usk02 615 28 for for IN cord-014516-r59usk02 615 29 renin renin NN cord-014516-r59usk02 615 30 and and CC cord-014516-r59usk02 615 31 11 11 CD cord-014516-r59usk02 615 32 % % NN cord-014516-r59usk02 615 33 for for IN cord-014516-r59usk02 615 34 aldosterone aldosterone NN cord-014516-r59usk02 615 35 . . . cord-014516-r59usk02 616 1 For for IN cord-014516-r59usk02 616 2 ET-1 ET-1 NNP cord-014516-r59usk02 616 3 , , , cord-014516-r59usk02 616 4 the the DT cord-014516-r59usk02 616 5 highest high JJS cord-014516-r59usk02 616 6 median median JJ cord-014516-r59usk02 616 7 concentration concentration NN cord-014516-r59usk02 616 8 was be VBD cord-014516-r59usk02 616 9 found find VBN cord-014516-r59usk02 616 10 in in IN cord-014516-r59usk02 616 11 Newfoundlands Newfoundlands NNPS cord-014516-r59usk02 616 12 with with IN cord-014516-r59usk02 616 13 values value NNS cord-014516-r59usk02 616 14 > > NFP cord-014516-r59usk02 616 15 3 3 CD cord-014516-r59usk02 616 16 times time NNS cord-014516-r59usk02 616 17 higher high JJR cord-014516-r59usk02 616 18 than than IN cord-014516-r59usk02 616 19 most most JJS cord-014516-r59usk02 616 20 other other JJ cord-014516-r59usk02 616 21 breeds breed NNS cord-014516-r59usk02 616 22 , , , cord-014516-r59usk02 616 23 while while IN cord-014516-r59usk02 616 24 renin renin NN cord-014516-r59usk02 616 25 was be VBD cord-014516-r59usk02 616 26 highest high JJS cord-014516-r59usk02 616 27 in in IN cord-014516-r59usk02 616 28 Dachshunds Dachshunds NNPS cord-014516-r59usk02 616 29 , , , cord-014516-r59usk02 616 30 > > SYM cord-014516-r59usk02 616 31 2 2 CD cord-014516-r59usk02 616 32 times time NNS cord-014516-r59usk02 616 33 higher high JJR cord-014516-r59usk02 616 34 than than IN cord-014516-r59usk02 616 35 in in IN cord-014516-r59usk02 616 36 Newfoundlands Newfoundlands NNPS cord-014516-r59usk02 616 37 and and CC cord-014516-r59usk02 616 38 Boxers Boxers NNPS cord-014516-r59usk02 616 39 , , , cord-014516-r59usk02 616 40 which which WDT cord-014516-r59usk02 616 41 had have VBD cord-014516-r59usk02 616 42 the the DT cord-014516-r59usk02 616 43 lowest low JJS cord-014516-r59usk02 616 44 concentrations concentration NNS cord-014516-r59usk02 616 45 . . . cord-014516-r59usk02 617 1 Aldosterone Aldosterone NNP cord-014516-r59usk02 617 2 was be VBD cord-014516-r59usk02 617 3 especially especially RB cord-014516-r59usk02 617 4 low low JJ cord-014516-r59usk02 617 5 in in IN cord-014516-r59usk02 617 6 Belgian belgian JJ cord-014516-r59usk02 617 7 Shepherds shepherd NNS cord-014516-r59usk02 617 8 with with IN cord-014516-r59usk02 617 9 median median JJ cord-014516-r59usk02 617 10 concentration concentration NN cord-014516-r59usk02 617 11 < < XX cord-014516-r59usk02 617 12 10 10 CD cord-014516-r59usk02 617 13 times time NNS cord-014516-r59usk02 617 14 than than IN cord-014516-r59usk02 617 15 the the DT cord-014516-r59usk02 617 16 other other JJ cord-014516-r59usk02 617 17 breeds breed NNS cord-014516-r59usk02 617 18 . . . cord-014516-r59usk02 618 1 Cortisol cortisol NN cord-014516-r59usk02 618 2 was be VBD cord-014516-r59usk02 618 3 highest high JJS cord-014516-r59usk02 618 4 in in IN cord-014516-r59usk02 618 5 Finnish finnish JJ cord-014516-r59usk02 618 6 Lapphunds Lapphunds NNP cord-014516-r59usk02 618 7 , , , cord-014516-r59usk02 618 8 almost almost RB cord-014516-r59usk02 618 9 3 3 CD cord-014516-r59usk02 618 10 times time NNS cord-014516-r59usk02 618 11 higher high JJR cord-014516-r59usk02 618 12 than than IN cord-014516-r59usk02 618 13 Boxers boxer NNS cord-014516-r59usk02 618 14 with with IN cord-014516-r59usk02 618 15 the the DT cord-014516-r59usk02 618 16 lowest low JJS cord-014516-r59usk02 618 17 concentration concentration NN cord-014516-r59usk02 618 18 . . . cord-014516-r59usk02 619 1 In in IN cord-014516-r59usk02 619 2 conclusion conclusion NN cord-014516-r59usk02 619 3 , , , cord-014516-r59usk02 619 4 considerable considerable JJ cord-014516-r59usk02 619 5 inter inter JJ cord-014516-r59usk02 619 6 - - JJ cord-014516-r59usk02 619 7 breed breed JJ cord-014516-r59usk02 619 8 variation variation NN cord-014516-r59usk02 619 9 in in IN cord-014516-r59usk02 619 10 concentrations concentration NNS cord-014516-r59usk02 619 11 of of IN cord-014516-r59usk02 619 12 ET-1 ET-1 NNP cord-014516-r59usk02 619 13 , , , cord-014516-r59usk02 619 14 components component NNS cord-014516-r59usk02 619 15 of of IN cord-014516-r59usk02 619 16 RAAS RAAS NNP cord-014516-r59usk02 619 17 and and CC cord-014516-r59usk02 619 18 cortisol cortisol NN cord-014516-r59usk02 619 19 was be VBD cord-014516-r59usk02 619 20 found find VBN cord-014516-r59usk02 619 21 in in IN cord-014516-r59usk02 619 22 healthy healthy JJ cord-014516-r59usk02 619 23 dogs dog NNS cord-014516-r59usk02 619 24 . . . cord-014516-r59usk02 620 1 These these DT cord-014516-r59usk02 620 2 differences difference NNS cord-014516-r59usk02 620 3 are be VBP cord-014516-r59usk02 620 4 likely likely RB cord-014516-r59usk02 620 5 influenced influence VBN cord-014516-r59usk02 620 6 by by IN cord-014516-r59usk02 620 7 genetic genetic JJ cord-014516-r59usk02 620 8 factors factor NNS cord-014516-r59usk02 620 9 and and CC cord-014516-r59usk02 620 10 should should MD cord-014516-r59usk02 620 11 be be VB cord-014516-r59usk02 620 12 taken take VBN cord-014516-r59usk02 620 13 into into IN cord-014516-r59usk02 620 14 account account NN cord-014516-r59usk02 620 15 when when WRB cord-014516-r59usk02 620 16 designing design VBG cord-014516-r59usk02 620 17 clinical clinical JJ cord-014516-r59usk02 620 18 trials trial NNS cord-014516-r59usk02 620 19 and and CC cord-014516-r59usk02 620 20 tests test NNS cord-014516-r59usk02 620 21 . . . cord-014516-r59usk02 621 1 Breed breed VB cord-014516-r59usk02 621 2 - - HYPH cord-014516-r59usk02 621 3 specific specific JJ cord-014516-r59usk02 621 4 reference reference NN cord-014516-r59usk02 621 5 ranges range NNS cord-014516-r59usk02 621 6 might may MD cord-014516-r59usk02 621 7 be be VB cord-014516-r59usk02 621 8 necessary necessary JJ cord-014516-r59usk02 621 9 . . . cord-014516-r59usk02 622 1 No no DT cord-014516-r59usk02 622 2 conflicts conflict NNS cord-014516-r59usk02 622 3 of of IN cord-014516-r59usk02 622 4 interest interest NN cord-014516-r59usk02 622 5 reported report VBN cord-014516-r59usk02 622 6 . . . cord-014516-r59usk02 623 1 Most Most JJS cord-014516-r59usk02 623 2 studies study NNS cord-014516-r59usk02 623 3 that that WDT cord-014516-r59usk02 623 4 assess assess VBP cord-014516-r59usk02 623 5 weight weight NN cord-014516-r59usk02 623 6 management management NN cord-014516-r59usk02 623 7 in in IN cord-014516-r59usk02 623 8 obese obese JJ cord-014516-r59usk02 623 9 dogs dog NNS cord-014516-r59usk02 623 10 only only RB cord-014516-r59usk02 623 11 examine examine VBP cord-014516-r59usk02 623 12 the the DT cord-014516-r59usk02 623 13 early early JJ cord-014516-r59usk02 623 14 stages stage NNS cord-014516-r59usk02 623 15 of of IN cord-014516-r59usk02 623 16 weight weight NN cord-014516-r59usk02 623 17 loss loss NN cord-014516-r59usk02 623 18 , , , cord-014516-r59usk02 623 19 and and CC cord-014516-r59usk02 623 20 this this DT cord-014516-r59usk02 623 21 may may MD cord-014516-r59usk02 623 22 not not RB cord-014516-r59usk02 623 23 properly properly RB cord-014516-r59usk02 623 24 reflect reflect VB cord-014516-r59usk02 623 25 a a DT cord-014516-r59usk02 623 26 complete complete JJ cord-014516-r59usk02 623 27 weight weight NN cord-014516-r59usk02 623 28 management management NN cord-014516-r59usk02 623 29 regime regime NN cord-014516-r59usk02 623 30 . . . cord-014516-r59usk02 624 1 The the DT cord-014516-r59usk02 624 2 aim aim NN cord-014516-r59usk02 624 3 of of IN cord-014516-r59usk02 624 4 the the DT cord-014516-r59usk02 624 5 current current JJ cord-014516-r59usk02 624 6 study study NN cord-014516-r59usk02 624 7 was be VBD cord-014516-r59usk02 624 8 to to TO cord-014516-r59usk02 624 9 examine examine VB cord-014516-r59usk02 624 10 the the DT cord-014516-r59usk02 624 11 kinetics kinetic NNS cord-014516-r59usk02 624 12 of of IN cord-014516-r59usk02 624 13 a a DT cord-014516-r59usk02 624 14 complete complete JJ cord-014516-r59usk02 624 15 weight weight NN cord-014516-r59usk02 624 16 management management NN cord-014516-r59usk02 624 17 cycle cycle NN cord-014516-r59usk02 624 18 in in IN cord-014516-r59usk02 624 19 obese obese JJ cord-014516-r59usk02 624 20 client client NN cord-014516-r59usk02 624 21 - - HYPH cord-014516-r59usk02 624 22 owned own VBN cord-014516-r59usk02 624 23 dogs dog NNS cord-014516-r59usk02 624 24 . . . cord-014516-r59usk02 625 1 Dogs dog NNS cord-014516-r59usk02 625 2 referred refer VBD cord-014516-r59usk02 625 3 to to IN cord-014516-r59usk02 625 4 the the DT cord-014516-r59usk02 625 5 Royal Royal NNP cord-014516-r59usk02 625 6 Canin Canin NNP cord-014516-r59usk02 625 7 Weight Weight NNP cord-014516-r59usk02 625 8 Management Management NNP cord-014516-r59usk02 625 9 Clinic Clinic NNP cord-014516-r59usk02 625 10 , , , cord-014516-r59usk02 625 11 University University NNP cord-014516-r59usk02 625 12 of of IN cord-014516-r59usk02 625 13 Liverpool Liverpool NNP cord-014516-r59usk02 625 14 , , , cord-014516-r59usk02 625 15 for for IN cord-014516-r59usk02 625 16 the the DT cord-014516-r59usk02 625 17 management management NN cord-014516-r59usk02 625 18 of of IN cord-014516-r59usk02 625 19 obesity obesity NN cord-014516-r59usk02 625 20 , , , cord-014516-r59usk02 625 21 were be VBD cord-014516-r59usk02 625 22 eligible eligible JJ cord-014516-r59usk02 625 23 for for IN cord-014516-r59usk02 625 24 inclusion inclusion NN cord-014516-r59usk02 625 25 . . . cord-014516-r59usk02 626 1 All all DT cord-014516-r59usk02 626 2 dogs dog NNS cord-014516-r59usk02 626 3 were be VBD cord-014516-r59usk02 626 4 followed follow VBN cord-014516-r59usk02 626 5 until until IN cord-014516-r59usk02 626 6 they -PRON- PRP cord-014516-r59usk02 626 7 had have VBD cord-014516-r59usk02 626 8 either either RB cord-014516-r59usk02 626 9 completed complete VBN cord-014516-r59usk02 626 10 ( ( -LRB- cord-014516-r59usk02 626 11 i.e. i.e. FW cord-014516-r59usk02 626 12 reached reach VBN cord-014516-r59usk02 626 13 target target NN cord-014516-r59usk02 626 14 weight weight NN cord-014516-r59usk02 626 15 ) ) -RRB- cord-014516-r59usk02 626 16 or or CC cord-014516-r59usk02 626 17 the the DT cord-014516-r59usk02 626 18 programme programme NN cord-014516-r59usk02 626 19 was be VBD cord-014516-r59usk02 626 20 discontinued discontinue VBN cord-014516-r59usk02 626 21 . . . cord-014516-r59usk02 627 1 Rate rate NN cord-014516-r59usk02 627 2 of of IN cord-014516-r59usk02 627 3 weight weight NN cord-014516-r59usk02 627 4 loss loss NN cord-014516-r59usk02 627 5 , , , cord-014516-r59usk02 627 6 percentage percentage NN cord-014516-r59usk02 627 7 weight weight NN cord-014516-r59usk02 627 8 lost lose VBN cord-014516-r59usk02 627 9 , , , cord-014516-r59usk02 627 10 and and CC cord-014516-r59usk02 627 11 energy energy NN cord-014516-r59usk02 627 12 were be VBD cord-014516-r59usk02 627 13 assessed assess VBN cord-014516-r59usk02 627 14 at at IN cord-014516-r59usk02 627 15 different different JJ cord-014516-r59usk02 627 16 time time NN cord-014516-r59usk02 627 17 points point NNS cord-014516-r59usk02 627 18 . . . cord-014516-r59usk02 628 1 A a DT cord-014516-r59usk02 628 2 total total NN cord-014516-r59usk02 628 3 of of IN cord-014516-r59usk02 628 4 149 149 CD cord-014516-r59usk02 628 5 dogs dog NNS cord-014516-r59usk02 628 6 were be VBD cord-014516-r59usk02 628 7 included include VBN cord-014516-r59usk02 628 8 , , , cord-014516-r59usk02 628 9 with with IN cord-014516-r59usk02 628 10 a a DT cord-014516-r59usk02 628 11 range range NN cord-014516-r59usk02 628 12 of of IN cord-014516-r59usk02 628 13 breeds breed NNS cord-014516-r59usk02 628 14 , , , cord-014516-r59usk02 628 15 ages age NNS cord-014516-r59usk02 628 16 and and CC cord-014516-r59usk02 628 17 sexes sex NNS cord-014516-r59usk02 628 18 represented represent VBN cord-014516-r59usk02 628 19 . . . cord-014516-r59usk02 629 1 Rate rate NN cord-014516-r59usk02 629 2 of of IN cord-014516-r59usk02 629 3 weight weight NN cord-014516-r59usk02 629 4 loss loss NN cord-014516-r59usk02 629 5 steadily steadily RB cord-014516-r59usk02 629 6 decreased decrease VBD cord-014516-r59usk02 629 7 throughout throughout IN cord-014516-r59usk02 629 8 the the DT cord-014516-r59usk02 629 9 weight weight NN cord-014516-r59usk02 629 10 loss loss NN cord-014516-r59usk02 629 11 period period NN cord-014516-r59usk02 629 12 ( ( -LRB- cord-014516-r59usk02 629 13 d28 d28 NN cord-014516-r59usk02 629 14 : : : cord-014516-r59usk02 629 15 1.2 1.2 CD cord-014516-r59usk02 629 16 AE AE NNP cord-014516-r59usk02 629 17 0.67%/wk 0.67%/wk NN cord-014516-r59usk02 629 18 ; ; : cord-014516-r59usk02 629 19 d56 d56 CD cord-014516-r59usk02 629 20 : : : cord-014516-r59usk02 629 21 0.8 0.8 CD cord-014516-r59usk02 629 22 AE AE NNP cord-014516-r59usk02 629 23 0.6%/wk 0.6%/wk NNP cord-014516-r59usk02 629 24 ; ; : cord-014516-r59usk02 629 25 d84 d84 NN cord-014516-r59usk02 629 26 : : : cord-014516-r59usk02 629 27 0.7 0.7 CD cord-014516-r59usk02 629 28 AE AE NNP cord-014516-r59usk02 629 29 0.5%/wk 0.5%/wk NNP cord-014516-r59usk02 629 30 ; ; : cord-014516-r59usk02 630 1 d168 d168 NNP cord-014516-r59usk02 630 2 : : : cord-014516-r59usk02 630 3 0.5 0.5 CD cord-014516-r59usk02 630 4 AE AE NNP cord-014516-r59usk02 630 5 0.4%/wk 0.4%/wk NN cord-014516-r59usk02 630 6 ; ; : cord-014516-r59usk02 630 7 d252 d252 NNP cord-014516-r59usk02 630 8 0.4 0.4 CD cord-014516-r59usk02 630 9 AE AE NNP cord-014516-r59usk02 630 10 0.3%/wk 0.3%/wk NN cord-014516-r59usk02 630 11 ; ; : cord-014516-r59usk02 630 12 d672 d672 NNP cord-014516-r59usk02 630 13 : : : cord-014516-r59usk02 630 14 0.1 0.1 CD cord-014516-r59usk02 630 15 AE AE NNP cord-014516-r59usk02 630 16 0.1%/wk 0.1%/wk NN cord-014516-r59usk02 630 17 ; ; : cord-014516-r59usk02 630 18 P p NN cord-014516-r59usk02 630 19 < < XX cord-014516-r59usk02 630 20 0.001 0.001 CD cord-014516-r59usk02 630 21 ) ) -RRB- cord-014516-r59usk02 630 22 . . . cord-014516-r59usk02 631 1 The the DT cord-014516-r59usk02 631 2 energy energy NN cord-014516-r59usk02 631 3 intake intake NN cord-014516-r59usk02 631 4 required require VBN cord-014516-r59usk02 631 5 to to TO cord-014516-r59usk02 631 6 maintain maintain VB cord-014516-r59usk02 631 7 weight weight NN cord-014516-r59usk02 631 8 loss loss NN cord-014516-r59usk02 631 9 also also RB cord-014516-r59usk02 631 10 progressively progressively RB cord-014516-r59usk02 631 11 decreased decrease VBD cord-014516-r59usk02 631 12 ( ( -LRB- cord-014516-r59usk02 631 13 P p NN cord-014516-r59usk02 631 14 < < XX cord-014516-r59usk02 631 15 0.001 0.001 CD cord-014516-r59usk02 631 16 ) ) -RRB- cord-014516-r59usk02 631 17 . . . cord-014516-r59usk02 632 1 By by IN cord-014516-r59usk02 632 2 day day NN cord-014516-r59usk02 632 3 84 84 CD cord-014516-r59usk02 632 4 , , , cord-014516-r59usk02 632 5 mean mean UH cord-014516-r59usk02 632 6 AEsd AEsd NNP cord-014516-r59usk02 632 7 weight weight NN cord-014516-r59usk02 632 8 loss loss NN cord-014516-r59usk02 632 9 was be VBD cord-014516-r59usk02 632 10 11 11 CD cord-014516-r59usk02 632 11 AE AE NNP cord-014516-r59usk02 632 12 4.9 4.9 CD cord-014516-r59usk02 632 13 % % NN cord-014516-r59usk02 632 14 , , , cord-014516-r59usk02 632 15 and and CC cord-014516-r59usk02 632 16 compliance compliance NN cord-014516-r59usk02 632 17 was be VBD cord-014516-r59usk02 632 18 good good JJ cord-014516-r59usk02 632 19 , , , cord-014516-r59usk02 632 20 but but CC cord-014516-r59usk02 632 21 most most JJS cord-014516-r59usk02 632 22 had have VBD cord-014516-r59usk02 632 23 not not RB cord-014516-r59usk02 632 24 com com NN cord-014516-r59usk02 632 25 - - HYPH cord-014516-r59usk02 632 26 pleted plete VBN cord-014516-r59usk02 632 27 ( ( -LRB- cord-014516-r59usk02 632 28 1 1 CD cord-014516-r59usk02 632 29 % % NN cord-014516-r59usk02 632 30 completed complete VBN cord-014516-r59usk02 632 31 , , , cord-014516-r59usk02 632 32 86 86 CD cord-014516-r59usk02 632 33 % % NN cord-014516-r59usk02 632 34 ongoing ongoing JJ cord-014516-r59usk02 632 35 , , , cord-014516-r59usk02 632 36 13 13 CD cord-014516-r59usk02 632 37 % % NN cord-014516-r59usk02 632 38 discontinued discontinue VBN cord-014516-r59usk02 632 39 ) ) -RRB- cord-014516-r59usk02 632 40 . . . cord-014516-r59usk02 633 1 Thereafter thereafter RB cord-014516-r59usk02 633 2 , , , cord-014516-r59usk02 633 3 more more JJR cord-014516-r59usk02 633 4 dogs dog NNS cord-014516-r59usk02 633 5 completed complete VBN cord-014516-r59usk02 633 6 , , , cord-014516-r59usk02 633 7 but but CC cord-014516-r59usk02 633 8 the the DT cord-014516-r59usk02 633 9 number number NN cord-014516-r59usk02 633 10 of of IN cord-014516-r59usk02 633 11 discontinuing discontinue VBG cord-014516-r59usk02 633 12 also also RB cord-014516-r59usk02 633 13 increased increase VBN cord-014516-r59usk02 633 14 ( ( -LRB- cord-014516-r59usk02 633 15 d252 d252 NNS cord-014516-r59usk02 633 16 : : : cord-014516-r59usk02 633 17 20 20 CD cord-014516-r59usk02 633 18 AE AE NNP cord-014516-r59usk02 633 19 7.7 7.7 CD cord-014516-r59usk02 633 20 % % NN cord-014516-r59usk02 633 21 weight weight NN cord-014516-r59usk02 633 22 loss loss NN cord-014516-r59usk02 633 23 , , , cord-014516-r59usk02 633 24 32 32 CD cord-014516-r59usk02 633 25 % % NN cord-014516-r59usk02 633 26 completed complete VBN cord-014516-r59usk02 633 27 , , , cord-014516-r59usk02 633 28 41 41 CD cord-014516-r59usk02 633 29 % % NN cord-014516-r59usk02 633 30 ongoing ongoing JJ cord-014516-r59usk02 633 31 , , , cord-014516-r59usk02 633 32 27 27 CD cord-014516-r59usk02 633 33 % % NN cord-014516-r59usk02 633 34 discontinued discontinue VBN cord-014516-r59usk02 633 35 ; ; : cord-014516-r59usk02 633 36 d672 d672 NNP cord-014516-r59usk02 633 37 : : : cord-014516-r59usk02 633 38 25 25 CD cord-014516-r59usk02 633 39 AE AE NNP cord-014516-r59usk02 633 40 14.6 14.6 CD cord-014516-r59usk02 633 41 % % NN cord-014516-r59usk02 633 42 weight weight NN cord-014516-r59usk02 633 43 loss loss NN cord-014516-r59usk02 633 44 ; ; : cord-014516-r59usk02 633 45 59 59 CD cord-014516-r59usk02 633 46 % % NN cord-014516-r59usk02 633 47 completed complete VBN cord-014516-r59usk02 633 48 , , , cord-014516-r59usk02 633 49 4 4 CD cord-014516-r59usk02 633 50 % % NN cord-014516-r59usk02 633 51 ongoing ongoing JJ cord-014516-r59usk02 633 52 , , , cord-014516-r59usk02 633 53 37 37 CD cord-014516-r59usk02 633 54 % % NN cord-014516-r59usk02 633 55 stopped stop VBD cord-014516-r59usk02 633 56 ) ) -RRB- cord-014516-r59usk02 633 57 . . . cord-014516-r59usk02 634 1 Initial initial JJ cord-014516-r59usk02 634 2 weight weight NN cord-014516-r59usk02 634 3 loss loss NN cord-014516-r59usk02 634 4 is be VBZ cord-014516-r59usk02 634 5 good good JJ cord-014516-r59usk02 634 6 in in IN cord-014516-r59usk02 634 7 obese obese JJ cord-014516-r59usk02 634 8 dogs dog NNS cord-014516-r59usk02 634 9 but but CC cord-014516-r59usk02 634 10 , , , cord-014516-r59usk02 634 11 thereafter thereafter RB cord-014516-r59usk02 634 12 , , , cord-014516-r59usk02 634 13 steadily steadily RB cord-014516-r59usk02 634 14 worsens worsen VBZ cord-014516-r59usk02 634 15 . . . cord-014516-r59usk02 635 1 Thus thus RB cord-014516-r59usk02 635 2 , , , cord-014516-r59usk02 635 3 studies study NNS cord-014516-r59usk02 635 4 examining examine VBG cord-014516-r59usk02 635 5 only only RB cord-014516-r59usk02 635 6 the the DT cord-014516-r59usk02 635 7 first first JJ cord-014516-r59usk02 635 8 few few JJ cord-014516-r59usk02 635 9 months month NNS cord-014516-r59usk02 635 10 of of IN cord-014516-r59usk02 635 11 weight weight NN cord-014516-r59usk02 635 12 loss loss NN cord-014516-r59usk02 635 13 are be VBP cord-014516-r59usk02 635 14 not not RB cord-014516-r59usk02 635 15 fully fully RB cord-014516-r59usk02 635 16 representative representative JJ cord-014516-r59usk02 635 17 of of IN cord-014516-r59usk02 635 18 the the DT cord-014516-r59usk02 635 19 entire entire JJ cord-014516-r59usk02 635 20 weight weight NN cord-014516-r59usk02 635 21 loss loss NN cord-014516-r59usk02 635 22 process process NN cord-014516-r59usk02 635 23 . . . cord-014516-r59usk02 636 1 Conflicts conflict NNS cord-014516-r59usk02 636 2 of of IN cord-014516-r59usk02 636 3 interest interest NN cord-014516-r59usk02 636 4 : : : cord-014516-r59usk02 636 5 The the DT cord-014516-r59usk02 636 6 following follow VBG cord-014516-r59usk02 636 7 conflicts conflict NNS cord-014516-r59usk02 636 8 of of IN cord-014516-r59usk02 636 9 interest interest NN cord-014516-r59usk02 636 10 apply apply VB cord-014516-r59usk02 636 11 : : : cord-014516-r59usk02 637 1 The the DT cord-014516-r59usk02 637 2 diet diet NN cord-014516-r59usk02 637 3 used use VBN cord-014516-r59usk02 637 4 in in IN cord-014516-r59usk02 637 5 this this DT cord-014516-r59usk02 637 6 study study NN cord-014516-r59usk02 637 7 is be VBZ cord-014516-r59usk02 637 8 manufactured manufacture VBN cord-014516-r59usk02 637 9 by by IN cord-014516-r59usk02 637 10 Royal Royal NNP cord-014516-r59usk02 637 11 Canin.whilst Canin.whilst NNP cord-014516-r59usk02 637 12 VB VB NNP cord-014516-r59usk02 637 13 is be VBZ cord-014516-r59usk02 637 14 employed employ VBN cord-014516-r59usk02 637 15 by by IN cord-014516-r59usk02 637 16 Royal Royal NNP cord-014516-r59usk02 637 17 Canin Canin NNP cord-014516-r59usk02 637 18 . . . cord-014516-r59usk02 638 1 VB VB NNP cord-014516-r59usk02 638 2 and and CC cord-014516-r59usk02 638 3 SS SS NNP cord-014516-r59usk02 638 4 are be VBP cord-014516-r59usk02 638 5 employed employ VBN cord-014516-r59usk02 638 6 by by IN cord-014516-r59usk02 638 7 Royal Royal NNP cord-014516-r59usk02 638 8 Canin Canin NNP cord-014516-r59usk02 638 9 . . . cord-014516-r59usk02 639 1 AJG AJG NNP cord-014516-r59usk02 639 2 's 's POS cord-014516-r59usk02 639 3 Readership Readership NNP cord-014516-r59usk02 639 4 is be VBZ cord-014516-r59usk02 639 5 funded fund VBN cord-014516-r59usk02 639 6 by by IN cord-014516-r59usk02 639 7 Royal Royal NNP cord-014516-r59usk02 639 8 Canin Canin NNP cord-014516-r59usk02 639 9 . . . cord-014516-r59usk02 640 1 Obesity obesity NN cord-014516-r59usk02 640 2 and and CC cord-014516-r59usk02 640 3 obesity obesity NN cord-014516-r59usk02 640 4 - - HYPH cord-014516-r59usk02 640 5 related relate VBN cord-014516-r59usk02 640 6 metabolic metabolic JJ cord-014516-r59usk02 640 7 dysfunctions dysfunction NNS cord-014516-r59usk02 640 8 are be VBP cord-014516-r59usk02 640 9 increasing increase VBG cord-014516-r59usk02 640 10 in in IN cord-014516-r59usk02 640 11 humans human NNS cord-014516-r59usk02 640 12 as as RB cord-014516-r59usk02 640 13 well well RB cord-014516-r59usk02 640 14 as as IN cord-014516-r59usk02 640 15 in in IN cord-014516-r59usk02 640 16 dogs dog NNS cord-014516-r59usk02 640 17 . . . cord-014516-r59usk02 641 1 Obese obese JJ cord-014516-r59usk02 641 2 dogs dog NNS cord-014516-r59usk02 641 3 become become VBP cord-014516-r59usk02 641 4 affected affect VBN cord-014516-r59usk02 641 5 by by IN cord-014516-r59usk02 641 6 chronic chronic JJ cord-014516-r59usk02 641 7 diseases disease NNS cord-014516-r59usk02 641 8 at at IN cord-014516-r59usk02 641 9 young young JJ cord-014516-r59usk02 641 10 age age NN cord-014516-r59usk02 641 11 , , , cord-014516-r59usk02 641 12 have have VBP cord-014516-r59usk02 641 13 a a DT cord-014516-r59usk02 641 14 decreased decrease VBN cord-014516-r59usk02 641 15 quality quality NN cord-014516-r59usk02 641 16 of of IN cord-014516-r59usk02 641 17 life life NN cord-014516-r59usk02 641 18 and and CC cord-014516-r59usk02 641 19 a a DT cord-014516-r59usk02 641 20 shorter short JJR cord-014516-r59usk02 641 21 life life NN cord-014516-r59usk02 641 22 - - HYPH cord-014516-r59usk02 641 23 span span NN cord-014516-r59usk02 641 24 . . . cord-014516-r59usk02 642 1 The the DT cord-014516-r59usk02 642 2 aim aim NN cord-014516-r59usk02 642 3 of of IN cord-014516-r59usk02 642 4 the the DT cord-014516-r59usk02 642 5 study study NN cord-014516-r59usk02 642 6 was be VBD cord-014516-r59usk02 642 7 to to TO cord-014516-r59usk02 642 8 describe describe VB cord-014516-r59usk02 642 9 the the DT cord-014516-r59usk02 642 10 metabolic metabolic JJ cord-014516-r59usk02 642 11 and and CC cord-014516-r59usk02 642 12 hormonal hormonal JJ cord-014516-r59usk02 642 13 response response NN cord-014516-r59usk02 642 14 to to IN cord-014516-r59usk02 642 15 a a DT cord-014516-r59usk02 642 16 feed feed NN cord-014516-r59usk02 642 17 - - HYPH cord-014516-r59usk02 642 18 challenge challenge NN cord-014516-r59usk02 642 19 test test NN cord-014516-r59usk02 642 20 in in IN cord-014516-r59usk02 642 21 lean lean JJ cord-014516-r59usk02 642 22 and and CC cord-014516-r59usk02 642 23 overweight overweight JJ cord-014516-r59usk02 642 24 dogs dog NNS cord-014516-r59usk02 642 25 . . . cord-014516-r59usk02 643 1 Twenty twenty CD cord-014516-r59usk02 643 2 - - HYPH cord-014516-r59usk02 643 3 eight eight CD cord-014516-r59usk02 643 4 healthy healthy JJ cord-014516-r59usk02 643 5 intact intact JJ cord-014516-r59usk02 643 6 male male JJ cord-014516-r59usk02 643 7 Labrador Labrador NNP cord-014516-r59usk02 643 8 retrievers retriever NNS cord-014516-r59usk02 643 9 aged age VBN cord-014516-r59usk02 643 10 5.2 5.2 CD cord-014516-r59usk02 643 11 AE AE NNP cord-014516-r59usk02 643 12 1.5 1.5 CD cord-014516-r59usk02 643 13 years year NNS cord-014516-r59usk02 643 14 with with IN cord-014516-r59usk02 643 15 varying vary VBG cord-014516-r59usk02 643 16 body body NN cord-014516-r59usk02 643 17 condition condition NN cord-014516-r59usk02 643 18 score score NN cord-014516-r59usk02 643 19 ( ( -LRB- cord-014516-r59usk02 643 20 BCS BCS NNP cord-014516-r59usk02 643 21 , , , cord-014516-r59usk02 643 22 scale scale NN cord-014516-r59usk02 643 23 1 1 CD cord-014516-r59usk02 643 24 - - SYM cord-014516-r59usk02 643 25 9 9 CD cord-014516-r59usk02 643 26 ) ) -RRB- cord-014516-r59usk02 643 27 were be VBD cord-014516-r59usk02 643 28 included include VBN cord-014516-r59usk02 643 29 . . . cord-014516-r59usk02 644 1 Twelve twelve CD cord-014516-r59usk02 644 2 dogs dog NNS cord-014516-r59usk02 644 3 were be VBD cord-014516-r59usk02 644 4 classified classify VBN cord-014516-r59usk02 644 5 as as IN cord-014516-r59usk02 644 6 lean lean JJ cord-014516-r59usk02 644 7 ( ( -LRB- cord-014516-r59usk02 644 8 BCS BCS NNP cord-014516-r59usk02 644 9 4 4 CD cord-014516-r59usk02 644 10 - - SYM cord-014516-r59usk02 644 11 5 5 CD cord-014516-r59usk02 644 12 ) ) -RRB- cord-014516-r59usk02 644 13 , , , cord-014516-r59usk02 644 14 ten ten CD cord-014516-r59usk02 644 15 as as IN cord-014516-r59usk02 644 16 slightly slightly RB cord-014516-r59usk02 644 17 overweight overweight JJ cord-014516-r59usk02 644 18 ( ( -LRB- cord-014516-r59usk02 644 19 BCS BCS NNP cord-014516-r59usk02 644 20 6 6 CD cord-014516-r59usk02 644 21 ) ) -RRB- cord-014516-r59usk02 644 22 and and CC cord-014516-r59usk02 644 23 six six CD cord-014516-r59usk02 644 24 as as IN cord-014516-r59usk02 644 25 overweight overweight JJ cord-014516-r59usk02 645 1 ( ( -LRB- cord-014516-r59usk02 645 2 BCS BCS NNP cord-014516-r59usk02 645 3 6.5 6.5 CD cord-014516-r59usk02 645 4 - - SYM cord-014516-r59usk02 645 5 8 8 CD cord-014516-r59usk02 645 6 ) ) -RRB- cord-014516-r59usk02 645 7 . . . cord-014516-r59usk02 646 1 An an DT cord-014516-r59usk02 646 2 overnight overnight JJ cord-014516-r59usk02 646 3 fasting fast VBG cord-014516-r59usk02 646 4 period period NN cord-014516-r59usk02 646 5 and and CC cord-014516-r59usk02 646 6 blood blood NN cord-014516-r59usk02 646 7 sample sample NN cord-014516-r59usk02 646 8 collection collection NN cord-014516-r59usk02 646 9 was be VBD cord-014516-r59usk02 646 10 followed follow VBN cord-014516-r59usk02 646 11 by by IN cord-014516-r59usk02 646 12 a a DT cord-014516-r59usk02 646 13 high high JJ cord-014516-r59usk02 646 14 fat fat NN cord-014516-r59usk02 646 15 meal meal NN cord-014516-r59usk02 646 16 . . . cord-014516-r59usk02 647 1 After after IN cord-014516-r59usk02 647 2 food food NN cord-014516-r59usk02 647 3 intake intake NN cord-014516-r59usk02 647 4 , , , cord-014516-r59usk02 647 5 blood blood NN cord-014516-r59usk02 647 6 samples sample NNS cord-014516-r59usk02 647 7 were be VBD cord-014516-r59usk02 647 8 collected collect VBN cord-014516-r59usk02 647 9 hourly hourly JJ cord-014516-r59usk02 647 10 for for IN cord-014516-r59usk02 647 11 four four CD cord-014516-r59usk02 647 12 hours hour NNS cord-014516-r59usk02 647 13 . . . cord-014516-r59usk02 648 1 A a DT cord-014516-r59usk02 648 2 Glucagon Glucagon NNP cord-014516-r59usk02 648 3 ELISA ELISA NNP cord-014516-r59usk02 648 4 was be VBD cord-014516-r59usk02 648 5 validated validate VBN cord-014516-r59usk02 648 6 for for IN cord-014516-r59usk02 648 7 use use NN cord-014516-r59usk02 648 8 in in IN cord-014516-r59usk02 648 9 dogs dog NNS cord-014516-r59usk02 648 10 . . . cord-014516-r59usk02 649 1 The the DT cord-014516-r59usk02 649 2 assigned assign VBN cord-014516-r59usk02 649 3 BCS BCS NNP cord-014516-r59usk02 649 4 was be VBD cord-014516-r59usk02 649 5 supported support VBN cord-014516-r59usk02 649 6 by by IN cord-014516-r59usk02 649 7 positive positive JJ cord-014516-r59usk02 649 8 association association NN cord-014516-r59usk02 649 9 with with IN cord-014516-r59usk02 649 10 serum serum NN cord-014516-r59usk02 649 11 leptin leptin NN cord-014516-r59usk02 649 12 concentrations concentration NNS cord-014516-r59usk02 649 13 . . . cord-014516-r59usk02 650 1 Postprandial postprandial JJ cord-014516-r59usk02 650 2 triglyceride triglyceride NN cord-014516-r59usk02 650 3 concentration concentration NN cord-014516-r59usk02 650 4 was be VBD cord-014516-r59usk02 650 5 significantly significantly RB cord-014516-r59usk02 650 6 higher high JJR cord-014516-r59usk02 650 7 in in IN cord-014516-r59usk02 650 8 the the DT cord-014516-r59usk02 650 9 overweight overweight JJ cord-014516-r59usk02 650 10 group group NN cord-014516-r59usk02 650 11 . . . cord-014516-r59usk02 651 1 A a DT cord-014516-r59usk02 651 2 tendency tendency NN cord-014516-r59usk02 651 3 to to IN cord-014516-r59usk02 651 4 higher high JJR cord-014516-r59usk02 651 5 cholesterol cholesterol NN cord-014516-r59usk02 651 6 concentration concentration NN cord-014516-r59usk02 651 7 was be VBD cord-014516-r59usk02 651 8 seen see VBN cord-014516-r59usk02 651 9 in in IN cord-014516-r59usk02 651 10 the the DT cord-014516-r59usk02 651 11 overweight overweight JJ cord-014516-r59usk02 651 12 group group NN cord-014516-r59usk02 651 13 but but CC cord-014516-r59usk02 651 14 cholesterol cholesterol NN cord-014516-r59usk02 651 15 was be VBD cord-014516-r59usk02 651 16 not not RB cord-014516-r59usk02 651 17 affected affect VBN cord-014516-r59usk02 651 18 by by IN cord-014516-r59usk02 651 19 food food NN cord-014516-r59usk02 651 20 intake intake NN cord-014516-r59usk02 651 21 . . . cord-014516-r59usk02 652 1 Glucagon glucagon NN cord-014516-r59usk02 652 2 concentration concentration NN cord-014516-r59usk02 652 3 rose rise VBD cord-014516-r59usk02 652 4 after after IN cord-014516-r59usk02 652 5 food food NN cord-014516-r59usk02 652 6 intake intake NN cord-014516-r59usk02 652 7 and and CC cord-014516-r59usk02 652 8 resembled resemble VBD cord-014516-r59usk02 652 9 the the DT cord-014516-r59usk02 652 10 response response NN cord-014516-r59usk02 652 11 seen see VBN cord-014516-r59usk02 652 12 in in IN cord-014516-r59usk02 652 13 humans human NNS cord-014516-r59usk02 652 14 after after IN cord-014516-r59usk02 652 15 a a DT cord-014516-r59usk02 652 16 mixed mixed JJ cord-014516-r59usk02 652 17 meal meal NN cord-014516-r59usk02 652 18 . . . cord-014516-r59usk02 653 1 Glucose glucose NN cord-014516-r59usk02 653 2 and and CC cord-014516-r59usk02 653 3 insulin insulin NN cord-014516-r59usk02 653 4 concentrations concentration NNS cord-014516-r59usk02 653 5 followed follow VBD cord-014516-r59usk02 653 6 the the DT cord-014516-r59usk02 653 7 same same JJ cord-014516-r59usk02 653 8 pattern pattern NN cord-014516-r59usk02 653 9 while while IN cord-014516-r59usk02 653 10 free free JJ cord-014516-r59usk02 653 11 fatty fatty JJ cord-014516-r59usk02 653 12 acids acid NNS cord-014516-r59usk02 653 13 had have VBD cord-014516-r59usk02 653 14 declined decline VBN cord-014516-r59usk02 653 15 one one CD cord-014516-r59usk02 653 16 hour hour NN cord-014516-r59usk02 653 17 after after IN cord-014516-r59usk02 653 18 the the DT cord-014516-r59usk02 653 19 meal meal NN cord-014516-r59usk02 653 20 . . . cord-014516-r59usk02 654 1 In in IN cord-014516-r59usk02 654 2 this this DT cord-014516-r59usk02 654 3 study study NN cord-014516-r59usk02 654 4 , , , cord-014516-r59usk02 654 5 the the DT cord-014516-r59usk02 654 6 metabolic metabolic JJ cord-014516-r59usk02 654 7 and and CC cord-014516-r59usk02 654 8 hormonal hormonal JJ cord-014516-r59usk02 654 9 response response NN cord-014516-r59usk02 654 10 to to IN cord-014516-r59usk02 654 11 a a DT cord-014516-r59usk02 654 12 high high JJ cord-014516-r59usk02 654 13 fat fat NN cord-014516-r59usk02 654 14 meal meal NN cord-014516-r59usk02 654 15 was be VBD cord-014516-r59usk02 654 16 similar similar JJ cord-014516-r59usk02 654 17 between between IN cord-014516-r59usk02 654 18 lean lean JJ cord-014516-r59usk02 654 19 and and CC cord-014516-r59usk02 654 20 slightly slightly RB cord-014516-r59usk02 654 21 overweight overweight JJ cord-014516-r59usk02 654 22 dogs dog NNS cord-014516-r59usk02 654 23 , , , cord-014516-r59usk02 654 24 whereas whereas IN cord-014516-r59usk02 654 25 the the DT cord-014516-r59usk02 654 26 response response NN cord-014516-r59usk02 654 27 of of IN cord-014516-r59usk02 654 28 overweight overweight JJ cord-014516-r59usk02 654 29 dogs dog NNS cord-014516-r59usk02 654 30 differed differ VBD cord-014516-r59usk02 654 31 . . . cord-014516-r59usk02 655 1 Studies study NNS cord-014516-r59usk02 655 2 on on IN cord-014516-r59usk02 655 3 the the DT cord-014516-r59usk02 655 4 health health NN cord-014516-r59usk02 655 5 significance significance NN cord-014516-r59usk02 655 6 of of IN cord-014516-r59usk02 655 7 postprandial postprandial JJ cord-014516-r59usk02 655 8 hypertriglyceridemia hypertriglyceridemia NN cord-014516-r59usk02 655 9 in in IN cord-014516-r59usk02 655 10 dogs dog NNS cord-014516-r59usk02 655 11 are be VBP cord-014516-r59usk02 655 12 warranted warrant VBN cord-014516-r59usk02 655 13 . . . cord-014516-r59usk02 656 1 Conflicts conflict NNS cord-014516-r59usk02 656 2 of of IN cord-014516-r59usk02 656 3 interest interest NN cord-014516-r59usk02 656 4 : : : cord-014516-r59usk02 656 5 The the DT cord-014516-r59usk02 656 6 study study NN cord-014516-r59usk02 656 7 was be VBD cord-014516-r59usk02 656 8 financially financially RB cord-014516-r59usk02 656 9 supported support VBN cord-014516-r59usk02 656 10 by by IN cord-014516-r59usk02 656 11 The the DT cord-014516-r59usk02 656 12 Swedish Swedish NNP cord-014516-r59usk02 656 13 Veterinarian Veterinarian NNP cord-014516-r59usk02 656 14 Federation Federation NNP cord-014516-r59usk02 656 15 , , , cord-014516-r59usk02 656 16 The the DT cord-014516-r59usk02 656 17 Companion Companion NNP cord-014516-r59usk02 656 18 Animal Animal NNP cord-014516-r59usk02 656 19 Research Research NNP cord-014516-r59usk02 656 20 Foundation Foundation NNP cord-014516-r59usk02 656 21 , , , cord-014516-r59usk02 656 22 and and CC cord-014516-r59usk02 656 23 The the DT cord-014516-r59usk02 656 24 Foundation Foundation NNP cord-014516-r59usk02 656 25 of of IN cord-014516-r59usk02 656 26 Thure Thure NNP cord-014516-r59usk02 656 27 F. F. NNP cord-014516-r59usk02 656 28 & & CC cord-014516-r59usk02 656 29 Karin Karin NNP cord-014516-r59usk02 656 30 Forsberg Forsberg NNP cord-014516-r59usk02 656 31 . . . cord-014516-r59usk02 657 1 Feline feline JJ cord-014516-r59usk02 657 2 weight weight NN cord-014516-r59usk02 657 3 - - HYPH cord-014516-r59usk02 657 4 loss loss NN cord-014516-r59usk02 657 5 programs program NNS cord-014516-r59usk02 657 6 are be VBP cord-014516-r59usk02 657 7 often often RB cord-014516-r59usk02 657 8 hindered hinder VBN cord-014516-r59usk02 657 9 by by IN cord-014516-r59usk02 657 10 compliance compliance NN cord-014516-r59usk02 657 11 issues issue NNS cord-014516-r59usk02 657 12 and and CC cord-014516-r59usk02 657 13 sedentary sedentary JJ cord-014516-r59usk02 657 14 lifestyle lifestyle NN cord-014516-r59usk02 657 15 . . . cord-014516-r59usk02 658 1 The the DT cord-014516-r59usk02 658 2 purpose purpose NN cord-014516-r59usk02 658 3 of of IN cord-014516-r59usk02 658 4 this this DT cord-014516-r59usk02 658 5 study study NN cord-014516-r59usk02 658 6 was be VBD cord-014516-r59usk02 658 7 to to TO cord-014516-r59usk02 658 8 assess assess VB cord-014516-r59usk02 658 9 the the DT cord-014516-r59usk02 658 10 effectiveness effectiveness NN cord-014516-r59usk02 658 11 of of IN cord-014516-r59usk02 658 12 a a DT cord-014516-r59usk02 658 13 new new JJ cord-014516-r59usk02 658 14 dietetic dietetic JJ cord-014516-r59usk02 658 15 weight weight NN cord-014516-r59usk02 658 16 management management NN cord-014516-r59usk02 658 17 food food NN cord-014516-r59usk02 658 18 ( ( -LRB- cord-014516-r59usk02 658 19 NDWMF NDWMF NNP cord-014516-r59usk02 658 20 ) ) -RRB- cord-014516-r59usk02 658 21 * * NFP cord-014516-r59usk02 658 22 in in IN cord-014516-r59usk02 658 23 achieving achieve VBG cord-014516-r59usk02 658 24 weight weight NN cord-014516-r59usk02 658 25 loss loss NN cord-014516-r59usk02 658 26 in in IN cord-014516-r59usk02 658 27 overweight overweight NN cord-014516-r59usk02 658 28 / / SYM cord-014516-r59usk02 658 29 obese obese JJ cord-014516-r59usk02 658 30 , , , cord-014516-r59usk02 658 31 client client NN cord-014516-r59usk02 658 32 - - HYPH cord-014516-r59usk02 658 33 owned own VBN cord-014516-r59usk02 658 34 cats cat NNS cord-014516-r59usk02 658 35 . . . cord-014516-r59usk02 659 1 The the DT cord-014516-r59usk02 659 2 objectives objective NNS cord-014516-r59usk02 659 3 were be VBD cord-014516-r59usk02 659 4 1 1 CD cord-014516-r59usk02 659 5 ) ) -RRB- cord-014516-r59usk02 659 6 to to TO cord-014516-r59usk02 659 7 evaluate evaluate VB cord-014516-r59usk02 659 8 weight weight NN cord-014516-r59usk02 659 9 loss loss NN cord-014516-r59usk02 659 10 parameters parameter NNS cord-014516-r59usk02 659 11 in in IN cord-014516-r59usk02 659 12 cats cat NNS cord-014516-r59usk02 659 13 fed feed VBD cord-014516-r59usk02 659 14 the the DT cord-014516-r59usk02 659 15 NDWMF NDWMF NNP cord-014516-r59usk02 659 16 * * NFP cord-014516-r59usk02 659 17 and and CC cord-014516-r59usk02 659 18 2 2 LS cord-014516-r59usk02 659 19 ) ) -RRB- cord-014516-r59usk02 659 20 to to TO cord-014516-r59usk02 659 21 describe describe VB cord-014516-r59usk02 659 22 the the DT cord-014516-r59usk02 659 23 owner owner NN cord-014516-r59usk02 659 24 's 's POS cord-014516-r59usk02 659 25 perception perception NN cord-014516-r59usk02 659 26 of of IN cord-014516-r59usk02 659 27 the the DT cord-014516-r59usk02 659 28 cat cat NN cord-014516-r59usk02 659 29 's 's POS cord-014516-r59usk02 659 30 quality quality NN cord-014516-r59usk02 659 31 of of IN cord-014516-r59usk02 659 32 life life NN cord-014516-r59usk02 659 33 . . . cord-014516-r59usk02 660 1 Overweight overweight JJ cord-014516-r59usk02 660 2 / / SYM cord-014516-r59usk02 660 3 obese obese JJ cord-014516-r59usk02 660 4 , , , cord-014516-r59usk02 660 5 otherwise otherwise RB cord-014516-r59usk02 660 6 healthy healthy JJ cord-014516-r59usk02 660 7 , , , cord-014516-r59usk02 660 8 client client NN cord-014516-r59usk02 660 9 - - HYPH cord-014516-r59usk02 660 10 owned own VBN cord-014516-r59usk02 660 11 cats cat NNS cord-014516-r59usk02 660 12 ( ( -LRB- cord-014516-r59usk02 660 13 > > NFP cord-014516-r59usk02 660 14 3/5 3/5 CD cord-014516-r59usk02 660 15 body body NN cord-014516-r59usk02 660 16 condition condition NN cord-014516-r59usk02 660 17 score score NN cord-014516-r59usk02 660 18 -BCS -bcs ADD cord-014516-r59usk02 660 19 ) ) -RRB- cord-014516-r59usk02 660 20 were be VBD cord-014516-r59usk02 660 21 enrolled enrol VBN cord-014516-r59usk02 660 22 in in IN cord-014516-r59usk02 660 23 the the DT cord-014516-r59usk02 660 24 study study NN cord-014516-r59usk02 660 25 ( ( -LRB- cord-014516-r59usk02 660 26 n n NN cord-014516-r59usk02 660 27 = = SYM cord-014516-r59usk02 660 28 132 132 CD cord-014516-r59usk02 660 29 ) ) -RRB- cord-014516-r59usk02 660 30 . . . cord-014516-r59usk02 661 1 Initial initial JJ cord-014516-r59usk02 661 2 veterinary veterinary JJ cord-014516-r59usk02 661 3 evaluation evaluation NN cord-014516-r59usk02 661 4 comprised comprise VBD cord-014516-r59usk02 661 5 a a DT cord-014516-r59usk02 661 6 physical physical JJ cord-014516-r59usk02 661 7 examination examination NN cord-014516-r59usk02 661 8 , , , cord-014516-r59usk02 661 9 nutritional nutritional JJ cord-014516-r59usk02 661 10 assess assess NN cord-014516-r59usk02 661 11 - - HYPH cord-014516-r59usk02 661 12 ment ment NN cord-014516-r59usk02 661 13 , , , cord-014516-r59usk02 661 14 determination determination NN cord-014516-r59usk02 661 15 of of IN cord-014516-r59usk02 661 16 ideal ideal JJ cord-014516-r59usk02 661 17 body body NN cord-014516-r59usk02 661 18 weight weight NN cord-014516-r59usk02 661 19 ( ( -LRB- cord-014516-r59usk02 661 20 IBW IBW NNP cord-014516-r59usk02 661 21 ) ) -RRB- cord-014516-r59usk02 661 22 , , , cord-014516-r59usk02 661 23 and and CC cord-014516-r59usk02 661 24 development development NN cord-014516-r59usk02 661 25 of of IN cord-014516-r59usk02 661 26 weight weight NN cord-014516-r59usk02 661 27 loss loss NN cord-014516-r59usk02 661 28 feeding feeding NN cord-014516-r59usk02 661 29 plan plan NN cord-014516-r59usk02 661 30 . . . cord-014516-r59usk02 662 1 Daily daily JJ cord-014516-r59usk02 662 2 energy energy NN cord-014516-r59usk02 662 3 requirement requirement NN cord-014516-r59usk02 662 4 ( ( -LRB- cord-014516-r59usk02 662 5 DER DER NNP cord-014516-r59usk02 662 6 ) ) -RRB- cord-014516-r59usk02 662 7 for for IN cord-014516-r59usk02 662 8 weight weight NN cord-014516-r59usk02 662 9 loss loss NN cord-014516-r59usk02 662 10 was be VBD cord-014516-r59usk02 662 11 calculated calculate VBN cord-014516-r59usk02 662 12 as as IN cord-014516-r59usk02 662 13 DER DER NNP cord-014516-r59usk02 662 14 = = SYM cord-014516-r59usk02 662 15 0.8 0.8 CD cord-014516-r59usk02 662 16 x x NN cord-014516-r59usk02 662 17 ( ( -LRB- cord-014516-r59usk02 662 18 70 70 CD cord-014516-r59usk02 662 19 x x SYM cord-014516-r59usk02 662 20 IBW IBW NNP cord-014516-r59usk02 662 21 kg kg NNP cord-014516-r59usk02 662 22 0.75 0.75 CD cord-014516-r59usk02 662 23 ) ) -RRB- cord-014516-r59usk02 662 24 . . . cord-014516-r59usk02 663 1 Initial initial JJ cord-014516-r59usk02 663 2 and and CC cord-014516-r59usk02 663 3 follow follow VB cord-014516-r59usk02 663 4 - - HYPH cord-014516-r59usk02 663 5 up up RP cord-014516-r59usk02 663 6 evaluations evaluation NNS cord-014516-r59usk02 663 7 ( ( -LRB- cord-014516-r59usk02 663 8 monthly monthly JJ cord-014516-r59usk02 663 9 for for IN cord-014516-r59usk02 663 10 6 6 CD cord-014516-r59usk02 663 11 months month NNS cord-014516-r59usk02 663 12 ) ) -RRB- cord-014516-r59usk02 663 13 consisted consist VBD cord-014516-r59usk02 663 14 in in IN cord-014516-r59usk02 663 15 determination determination NN cord-014516-r59usk02 663 16 of of IN cord-014516-r59usk02 663 17 body body NN cord-014516-r59usk02 663 18 weight weight NN cord-014516-r59usk02 663 19 ( ( -LRB- cord-014516-r59usk02 663 20 BW BW NNP cord-014516-r59usk02 663 21 ) ) -RRB- cord-014516-r59usk02 663 22 , , , cord-014516-r59usk02 663 23 BCS BCS NNP cord-014516-r59usk02 663 24 , , , cord-014516-r59usk02 663 25 body body NN cord-014516-r59usk02 663 26 fat fat NN cord-014516-r59usk02 663 27 index index NN cord-014516-r59usk02 663 28 ( ( -LRB- cord-014516-r59usk02 663 29 BFI BFI NNP cord-014516-r59usk02 663 30 ) ) -RRB- cord-014516-r59usk02 663 31 , , , cord-014516-r59usk02 663 32 muscle muscle NN cord-014516-r59usk02 663 33 condition condition NN cord-014516-r59usk02 663 34 score score NN cord-014516-r59usk02 663 35 ( ( -LRB- cord-014516-r59usk02 663 36 MCS MCS NNP cord-014516-r59usk02 663 37 ) ) -RRB- cord-014516-r59usk02 663 38 , , , cord-014516-r59usk02 663 39 and and CC cord-014516-r59usk02 663 40 current current JJ cord-014516-r59usk02 663 41 feeding feeding NN cord-014516-r59usk02 663 42 practices practice NNS cord-014516-r59usk02 663 43 . . . cord-014516-r59usk02 664 1 Quality quality NN cord-014516-r59usk02 664 2 of of IN cord-014516-r59usk02 664 3 life life NN cord-014516-r59usk02 664 4 assessment assessment NN cord-014516-r59usk02 664 5 by by IN cord-014516-r59usk02 664 6 owners owner NNS cord-014516-r59usk02 664 7 included include VBD cord-014516-r59usk02 664 8 cat cat NN cord-014516-r59usk02 664 9 's 's POS cord-014516-r59usk02 664 10 level level NN cord-014516-r59usk02 664 11 of of IN cord-014516-r59usk02 664 12 energy energy NN cord-014516-r59usk02 664 13 , , , cord-014516-r59usk02 664 14 happiness happiness NN cord-014516-r59usk02 664 15 , , , cord-014516-r59usk02 664 16 appetite appetite NN cord-014516-r59usk02 664 17 , , , cord-014516-r59usk02 664 18 begging beg VBG cord-014516-r59usk02 664 19 behavior behavior NN cord-014516-r59usk02 664 20 , , , cord-014516-r59usk02 664 21 flatulence flatulence NN cord-014516-r59usk02 664 22 , , , cord-014516-r59usk02 664 23 stool stool NN cord-014516-r59usk02 664 24 volume volume NN cord-014516-r59usk02 664 25 , , , cord-014516-r59usk02 664 26 and and CC cord-014516-r59usk02 664 27 fecal fecal JJ cord-014516-r59usk02 664 28 score score NN cord-014516-r59usk02 664 29 . . . cord-014516-r59usk02 665 1 Statistical statistical JJ cord-014516-r59usk02 665 2 analysis analysis NN cord-014516-r59usk02 665 3 encompassed encompass VBD cord-014516-r59usk02 665 4 scatterplots scatterplot NNS cord-014516-r59usk02 665 5 , , , cord-014516-r59usk02 665 6 regression regression NN cord-014516-r59usk02 665 7 analysis analysis NN cord-014516-r59usk02 665 8 , , , cord-014516-r59usk02 665 9 summary summary NN cord-014516-r59usk02 665 10 statistics statistic NNS cord-014516-r59usk02 665 11 as as IN cord-014516-r59usk02 665 12 appropriate appropriate JJ cord-014516-r59usk02 665 13 for for IN cord-014516-r59usk02 665 14 the the DT cord-014516-r59usk02 665 15 type type NN cord-014516-r59usk02 665 16 of of IN cord-014516-r59usk02 665 17 analyses analysis NNS cord-014516-r59usk02 665 18 ( ( -LRB- cord-014516-r59usk02 665 19 continuous continuous JJ cord-014516-r59usk02 665 20 or or CC cord-014516-r59usk02 665 21 categorical categorical JJ cord-014516-r59usk02 665 22 variables variable NNS cord-014516-r59usk02 665 23 , , , cord-014516-r59usk02 665 24 distribution distribution NN cord-014516-r59usk02 665 25 ) ) -RRB- cord-014516-r59usk02 665 26 , , , cord-014516-r59usk02 665 27 a a DT cord-014516-r59usk02 665 28 mixed mixed JJ cord-014516-r59usk02 665 29 model model NN cord-014516-r59usk02 665 30 ANOVA ANOVA NNP cord-014516-r59usk02 665 31 was be VBD cord-014516-r59usk02 665 32 used use VBN cord-014516-r59usk02 665 33 to to TO cord-014516-r59usk02 665 34 assess assess VB cord-014516-r59usk02 665 35 changes change NNS cord-014516-r59usk02 665 36 over over IN cord-014516-r59usk02 665 37 time time NN cord-014516-r59usk02 665 38 ( ( -LRB- cord-014516-r59usk02 665 39 statistical statistical JJ cord-014516-r59usk02 665 40 significance significance NN cord-014516-r59usk02 665 41 at at IN cord-014516-r59usk02 665 42 p p NN cord-014516-r59usk02 665 43 < < XX cord-014516-r59usk02 665 44 0.05 0.05 CD cord-014516-r59usk02 665 45 ) ) -RRB- cord-014516-r59usk02 665 46 . . . cord-014516-r59usk02 666 1 Eighty eighty CD cord-014516-r59usk02 666 2 three three CD cord-014516-r59usk02 666 3 percent percent NN cord-014516-r59usk02 666 4 of of IN cord-014516-r59usk02 666 5 the the DT cord-014516-r59usk02 666 6 cats cat NNS cord-014516-r59usk02 666 7 ( ( -LRB- cord-014516-r59usk02 666 8 n n NN cord-014516-r59usk02 666 9 = = SYM cord-014516-r59usk02 666 10 110 110 CD cord-014516-r59usk02 666 11 ) ) -RRB- cord-014516-r59usk02 666 12 lost lose VBD cord-014516-r59usk02 666 13 weight weight NN cord-014516-r59usk02 666 14 with with IN cord-014516-r59usk02 666 15 an an DT cord-014516-r59usk02 666 16 average average JJ cord-014516-r59usk02 666 17 weight weight NN cord-014516-r59usk02 666 18 loss loss NN cord-014516-r59usk02 666 19 of of IN cord-014516-r59usk02 666 20 11 11 CD cord-014516-r59usk02 666 21 % % NN cord-014516-r59usk02 666 22 ( ( -LRB- cord-014516-r59usk02 666 23 SEM SEM NNP cord-014516-r59usk02 666 24 , , , cord-014516-r59usk02 666 25 1.8 1.8 CD cord-014516-r59usk02 666 26 % % NN cord-014516-r59usk02 666 27 ) ) -RRB- cord-014516-r59usk02 666 28 over over IN cord-014516-r59usk02 666 29 6 6 CD cord-014516-r59usk02 666 30 months month NNS cord-014516-r59usk02 666 31 and and CC cord-014516-r59usk02 666 32 an an DT cord-014516-r59usk02 666 33 average average JJ cord-014516-r59usk02 666 34 weekly weekly JJ cord-014516-r59usk02 666 35 weight weight NN cord-014516-r59usk02 666 36 loss loss NN cord-014516-r59usk02 666 37 rate rate NN cord-014516-r59usk02 666 38 of of IN cord-014516-r59usk02 666 39 0.45 0.45 CD cord-014516-r59usk02 666 40 % % NN cord-014516-r59usk02 666 41 ( ( -LRB- cord-014516-r59usk02 666 42 SEM SEM NNP cord-014516-r59usk02 666 43 , , , cord-014516-r59usk02 666 44 0.03 0.03 CD cord-014516-r59usk02 666 45 % % NN cord-014516-r59usk02 666 46 ) ) -RRB- cord-014516-r59usk02 666 47 . . . cord-014516-r59usk02 667 1 A a DT cord-014516-r59usk02 667 2 significant significant JJ cord-014516-r59usk02 667 3 decrease decrease NN cord-014516-r59usk02 667 4 in in IN cord-014516-r59usk02 667 5 BCS BCS NNP cord-014516-r59usk02 667 6 from from IN cord-014516-r59usk02 667 7 week week NN cord-014516-r59usk02 667 8 12 12 CD cord-014516-r59usk02 667 9 - - SYM cord-014516-r59usk02 667 10 24 24 CD cord-014516-r59usk02 667 11 and and CC cord-014516-r59usk02 667 12 in in IN cord-014516-r59usk02 667 13 BFI BFI NNP cord-014516-r59usk02 667 14 from from IN cord-014516-r59usk02 667 15 week week NN cord-014516-r59usk02 667 16 8 8 CD cord-014516-r59usk02 667 17 - - SYM cord-014516-r59usk02 667 18 24 24 CD cord-014516-r59usk02 667 19 compared compare VBN cord-014516-r59usk02 667 20 to to IN cord-014516-r59usk02 667 21 baseline baseline NN cord-014516-r59usk02 667 22 was be VBD cord-014516-r59usk02 667 23 observed observe VBN cord-014516-r59usk02 667 24 . . . cord-014516-r59usk02 668 1 MCS MCS NNP cord-014516-r59usk02 668 2 did do VBD cord-014516-r59usk02 668 3 not not RB cord-014516-r59usk02 668 4 change change VB cord-014516-r59usk02 668 5 . . . cord-014516-r59usk02 669 1 Average average JJ cord-014516-r59usk02 669 2 duration duration NN cord-014516-r59usk02 669 3 of of IN cord-014516-r59usk02 669 4 weight weight NN cord-014516-r59usk02 669 5 loss loss NN cord-014516-r59usk02 669 6 was be VBD cord-014516-r59usk02 669 7 134 134 CD cord-014516-r59usk02 669 8 days day NNS cord-014516-r59usk02 669 9 ( ( -LRB- cord-014516-r59usk02 669 10 SEM SEM NNP cord-014516-r59usk02 669 11 , , , cord-014516-r59usk02 669 12 4.8 4.8 CD cord-014516-r59usk02 669 13 days day NNS cord-014516-r59usk02 669 14 ) ) -RRB- cord-014516-r59usk02 669 15 with with IN cord-014516-r59usk02 669 16 32 32 CD cord-014516-r59usk02 669 17 days day NNS cord-014516-r59usk02 669 18 ( ( -LRB- cord-014516-r59usk02 669 19 SEM SEM NNP cord-014516-r59usk02 669 20 , , , cord-014516-r59usk02 669 21 0.5 0.5 CD cord-014516-r59usk02 669 22 days day NNS cord-014516-r59usk02 669 23 ) ) -RRB- cord-014516-r59usk02 669 24 between between IN cord-014516-r59usk02 669 25 visits visit NNS cord-014516-r59usk02 669 26 . . . cord-014516-r59usk02 670 1 Fourteen fourteen CD cord-014516-r59usk02 670 2 percent percent NN cord-014516-r59usk02 670 3 of of IN cord-014516-r59usk02 670 4 cats cat NNS cord-014516-r59usk02 670 5 achieved achieve VBN cord-014516-r59usk02 670 6 IBW IBW NNP cord-014516-r59usk02 670 7 ( ( -LRB- cord-014516-r59usk02 670 8 0.14 0.14 CD cord-014516-r59usk02 670 9 , , , cord-014516-r59usk02 670 10 CI CI NNP cord-014516-r59usk02 670 11 : : : cord-014516-r59usk02 670 12 0.08 0.08 CD cord-014516-r59usk02 670 13 - - HYPH cord-014516-r59usk02 670 14 0.22 0.22 CD cord-014516-r59usk02 670 15 ) ) -RRB- cord-014516-r59usk02 670 16 . . . cord-014516-r59usk02 671 1 Seventy seventy CD cord-014516-r59usk02 671 2 nine nine CD cord-014516-r59usk02 671 3 percent percent NN cord-014516-r59usk02 671 4 of of IN cord-014516-r59usk02 671 5 cats cat NNS cord-014516-r59usk02 671 6 ate eat VBD cord-014516-r59usk02 671 7 more more JJR cord-014516-r59usk02 671 8 than than IN cord-014516-r59usk02 671 9 the the DT cord-014516-r59usk02 671 10 recommended recommend VBN cord-014516-r59usk02 671 11 DER DER NNP cord-014516-r59usk02 671 12 ( ( -LRB- cord-014516-r59usk02 671 13 median median NN cord-014516-r59usk02 671 14 fed feed VBN cord-014516-r59usk02 671 15 above above IN cord-014516-r59usk02 671 16 DER=6 der=6 VBP cord-014516-r59usk02 671 17 % % NN cord-014516-r59usk02 671 18 ) ) -RRB- cord-014516-r59usk02 671 19 , , , cord-014516-r59usk02 671 20 and and CC cord-014516-r59usk02 671 21 the the DT cord-014516-r59usk02 671 22 majority majority NN cord-014516-r59usk02 671 23 of of IN cord-014516-r59usk02 671 24 these these DT cord-014516-r59usk02 671 25 cats cat NNS cord-014516-r59usk02 671 26 still still RB cord-014516-r59usk02 671 27 lost lose VBD cord-014516-r59usk02 671 28 weight weight NN cord-014516-r59usk02 671 29 . . . cord-014516-r59usk02 672 1 Owners owner NNS cord-014516-r59usk02 672 2 perceived perceive VBD cord-014516-r59usk02 672 3 a a DT cord-014516-r59usk02 672 4 significant significant JJ cord-014516-r59usk02 672 5 increase increase NN cord-014516-r59usk02 672 6 in in IN cord-014516-r59usk02 672 7 energy energy NN cord-014516-r59usk02 672 8 and and CC cord-014516-r59usk02 672 9 happiness happiness NN cord-014516-r59usk02 672 10 ( ( -LRB- cord-014516-r59usk02 672 11 > > NFP cord-014516-r59usk02 672 12 week week NN cord-014516-r59usk02 672 13 12 12 CD cord-014516-r59usk02 672 14 ) ) -RRB- cord-014516-r59usk02 672 15 compared compare VBN cord-014516-r59usk02 672 16 to to IN cord-014516-r59usk02 672 17 baseline baseline NN cord-014516-r59usk02 672 18 in in IN cord-014516-r59usk02 672 19 the the DT cord-014516-r59usk02 672 20 cats cat NNS cord-014516-r59usk02 672 21 that that WDT cord-014516-r59usk02 672 22 lost lose VBD cord-014516-r59usk02 672 23 weight weight NN cord-014516-r59usk02 672 24 without without IN cord-014516-r59usk02 672 25 changes change NNS cord-014516-r59usk02 672 26 in in IN cord-014516-r59usk02 672 27 appetite appetite NN cord-014516-r59usk02 672 28 or or CC cord-014516-r59usk02 672 29 begging beg VBG cord-014516-r59usk02 672 30 behavior behavior NN cord-014516-r59usk02 672 31 . . . cord-014516-r59usk02 673 1 No no DT cord-014516-r59usk02 673 2 significant significant JJ cord-014516-r59usk02 673 3 changes change NNS cord-014516-r59usk02 673 4 were be VBD cord-014516-r59usk02 673 5 seen see VBN cord-014516-r59usk02 673 6 in in IN cord-014516-r59usk02 673 7 scores score NNS cord-014516-r59usk02 673 8 for for IN cord-014516-r59usk02 673 9 flatulence flatulence NN cord-014516-r59usk02 673 10 , , , cord-014516-r59usk02 673 11 stool stool NN cord-014516-r59usk02 673 12 volume volume NN cord-014516-r59usk02 673 13 , , , cord-014516-r59usk02 673 14 and and CC cord-014516-r59usk02 673 15 fecal fecal JJ cord-014516-r59usk02 673 16 score score NN cord-014516-r59usk02 673 17 . . . cord-014516-r59usk02 674 1 In in IN cord-014516-r59usk02 674 2 conclusion conclusion NN cord-014516-r59usk02 674 3 , , , cord-014516-r59usk02 674 4 this this DT cord-014516-r59usk02 674 5 clinical clinical JJ cord-014516-r59usk02 674 6 study study NN cord-014516-r59usk02 674 7 showed show VBD cord-014516-r59usk02 674 8 that that IN cord-014516-r59usk02 674 9 feeding feed VBG cord-014516-r59usk02 674 10 the the DT cord-014516-r59usk02 674 11 NDWMF NDWMF NNP cord-014516-r59usk02 674 12 * * NFP cord-014516-r59usk02 674 13 to to IN cord-014516-r59usk02 674 14 client client NN cord-014516-r59usk02 674 15 - - HYPH cord-014516-r59usk02 674 16 owned own VBN cord-014516-r59usk02 674 17 , , , cord-014516-r59usk02 674 18 overweight overweight JJ cord-014516-r59usk02 674 19 / / SYM cord-014516-r59usk02 674 20 obese obese JJ cord-014516-r59usk02 674 21 cats cat NNS cord-014516-r59usk02 674 22 resulted result VBD cord-014516-r59usk02 674 23 in in IN cord-014516-r59usk02 674 24 weight weight NN cord-014516-r59usk02 674 25 loss loss NN cord-014516-r59usk02 674 26 . . . cord-014516-r59usk02 675 1 Owners owner NNS cord-014516-r59usk02 675 2 reported report VBD cord-014516-r59usk02 675 3 significant significant JJ cord-014516-r59usk02 675 4 improvements improvement NNS cord-014516-r59usk02 675 5 in in IN cord-014516-r59usk02 675 6 cat cat NN cord-014516-r59usk02 675 7 's 's POS cord-014516-r59usk02 675 8 quality quality NN cord-014516-r59usk02 675 9 of of IN cord-014516-r59usk02 675 10 life life NN cord-014516-r59usk02 675 11 without without IN cord-014516-r59usk02 675 12 negative negative JJ cord-014516-r59usk02 675 13 side side NN cord-014516-r59usk02 675 14 effects effect NNS cord-014516-r59usk02 675 15 . . . cord-014516-r59usk02 676 1 * * NFP cord-014516-r59usk02 676 2 Porphyrias Porphyrias NNP cord-014516-r59usk02 676 3 are be VBP cord-014516-r59usk02 676 4 a a DT cord-014516-r59usk02 676 5 group group NN cord-014516-r59usk02 676 6 of of IN cord-014516-r59usk02 676 7 inborn inborn JJ cord-014516-r59usk02 676 8 errors error NNS cord-014516-r59usk02 676 9 of of IN cord-014516-r59usk02 676 10 metabolism metabolism NN cord-014516-r59usk02 676 11 resulting result VBG cord-014516-r59usk02 676 12 from from IN cord-014516-r59usk02 676 13 accumulation accumulation NN cord-014516-r59usk02 676 14 of of IN cord-014516-r59usk02 676 15 porphyrins porphyrin NNS cord-014516-r59usk02 676 16 due due JJ cord-014516-r59usk02 676 17 to to IN cord-014516-r59usk02 676 18 deficient deficient JJ cord-014516-r59usk02 676 19 activities activity NNS cord-014516-r59usk02 676 20 of of IN cord-014516-r59usk02 676 21 specific specific JJ cord-014516-r59usk02 676 22 enzymes enzyme NNS cord-014516-r59usk02 676 23 in in IN cord-014516-r59usk02 676 24 heme heme NN cord-014516-r59usk02 676 25 biosynthesis biosynthesis NN cord-014516-r59usk02 676 26 . . . cord-014516-r59usk02 677 1 In in IN cord-014516-r59usk02 677 2 humans human NNS cord-014516-r59usk02 677 3 , , , cord-014516-r59usk02 677 4 they -PRON- PRP cord-014516-r59usk02 677 5 are be VBP cord-014516-r59usk02 677 6 clinically clinically RB cord-014516-r59usk02 677 7 classified classified JJ cord-014516-r59usk02 677 8 as as IN cord-014516-r59usk02 677 9 either either DT cord-014516-r59usk02 677 10 erythroid erythroid NN cord-014516-r59usk02 677 11 with with IN cord-014516-r59usk02 677 12 cutaneous cutaneous JJ cord-014516-r59usk02 677 13 involvement involvement NN cord-014516-r59usk02 677 14 or or CC cord-014516-r59usk02 677 15 hepatic hepatic JJ cord-014516-r59usk02 677 16 with with IN cord-014516-r59usk02 677 17 acute acute JJ cord-014516-r59usk02 677 18 neurovisceral neurovisceral JJ cord-014516-r59usk02 677 19 attacks attack NNS cord-014516-r59usk02 677 20 . . . cord-014516-r59usk02 678 1 Here here RB cord-014516-r59usk02 678 2 we -PRON- PRP cord-014516-r59usk02 678 3 describe describe VBP cord-014516-r59usk02 678 4 the the DT cord-014516-r59usk02 678 5 clinical clinical JJ cord-014516-r59usk02 678 6 , , , cord-014516-r59usk02 678 7 biochemical biochemical JJ cord-014516-r59usk02 678 8 , , , cord-014516-r59usk02 678 9 and and CC cord-014516-r59usk02 678 10 molecular molecular JJ cord-014516-r59usk02 678 11 genetic genetic JJ cord-014516-r59usk02 678 12 studies study NNS cord-014516-r59usk02 678 13 in in IN cord-014516-r59usk02 678 14 porphyric porphyric JJ cord-014516-r59usk02 678 15 cats cat NNS cord-014516-r59usk02 678 16 from from IN cord-014516-r59usk02 678 17 New New NNP cord-014516-r59usk02 678 18 Brunswick Brunswick NNP cord-014516-r59usk02 678 19 , , , cord-014516-r59usk02 678 20 Canada Canada NNP cord-014516-r59usk02 678 21 . . . cord-014516-r59usk02 679 1 From from IN cord-014516-r59usk02 679 2 2008 2008 CD cord-014516-r59usk02 679 3 to to IN cord-014516-r59usk02 679 4 2014 2014 CD cord-014516-r59usk02 679 5 , , , cord-014516-r59usk02 679 6 three three CD cord-014516-r59usk02 679 7 separately separately RB cord-014516-r59usk02 679 8 identified identify VBN cord-014516-r59usk02 679 9 adult adult NN cord-014516-r59usk02 679 10 domestic domestic JJ cord-014516-r59usk02 679 11 shorthair shorthair JJ cord-014516-r59usk02 679 12 cats cat NNS cord-014516-r59usk02 679 13 from from IN cord-014516-r59usk02 679 14 the the DT cord-014516-r59usk02 679 15 city city NN cord-014516-r59usk02 679 16 of of IN cord-014516-r59usk02 679 17 Saint Saint NNP cord-014516-r59usk02 679 18 John John NNP cord-014516-r59usk02 679 19 in in IN cord-014516-r59usk02 679 20 New New NNP cord-014516-r59usk02 679 21 Brunswick Brunswick NNP cord-014516-r59usk02 679 22 were be VBD cord-014516-r59usk02 679 23 found find VBN cord-014516-r59usk02 679 24 to to TO cord-014516-r59usk02 679 25 have have VB cord-014516-r59usk02 679 26 erythrodontia erythrodontia VBN cord-014516-r59usk02 679 27 ( ( -LRB- cord-014516-r59usk02 679 28 brown brown JJ cord-014516-r59usk02 679 29 discolored discolored JJ cord-014516-r59usk02 679 30 teeth tooth NNS cord-014516-r59usk02 679 31 which which WDT cord-014516-r59usk02 679 32 fluoresced fluoresce VBD cord-014516-r59usk02 679 33 pink pink NN cord-014516-r59usk02 679 34 ) ) -RRB- cord-014516-r59usk02 679 35 and and CC cord-014516-r59usk02 679 36 pigmenturia pigmenturia NNS cord-014516-r59usk02 679 37 . . . cord-014516-r59usk02 680 1 A a DT cord-014516-r59usk02 680 2 mild mild JJ cord-014516-r59usk02 680 3 compensated compensate VBN cord-014516-r59usk02 680 4 hemolytic hemolytic JJ cord-014516-r59usk02 680 5 disorder disorder NN cord-014516-r59usk02 680 6 with with IN cord-014516-r59usk02 680 7 numerous numerous JJ cord-014516-r59usk02 680 8 small small JJ cord-014516-r59usk02 680 9 dark dark JJ cord-014516-r59usk02 680 10 blue blue JJ cord-014516-r59usk02 680 11 irregularly irregularly RB cord-014516-r59usk02 680 12 shaped shape VBN cord-014516-r59usk02 680 13 erythrocyte erythrocyte NN cord-014516-r59usk02 680 14 inclusions inclusion NNS cord-014516-r59usk02 680 15 was be VBD cord-014516-r59usk02 680 16 noted note VBN cord-014516-r59usk02 680 17 . . . cord-014516-r59usk02 681 1 There there EX cord-014516-r59usk02 681 2 was be VBD cord-014516-r59usk02 681 3 no no DT cord-014516-r59usk02 681 4 evidence evidence NN cord-014516-r59usk02 681 5 of of IN cord-014516-r59usk02 681 6 acute acute JJ cord-014516-r59usk02 681 7 lifethreatening lifethreatening JJ cord-014516-r59usk02 681 8 neurovisceral neurovisceral JJ cord-014516-r59usk02 681 9 attacks attack NNS cord-014516-r59usk02 681 10 or or CC cord-014516-r59usk02 681 11 cutaneous cutaneous JJ cord-014516-r59usk02 681 12 lesions lesion NNS cord-014516-r59usk02 681 13 . . . cord-014516-r59usk02 682 1 Necropsy necropsy JJ cord-014516-r59usk02 682 2 of of IN cord-014516-r59usk02 682 3 one one CD cord-014516-r59usk02 682 4 cat cat NN cord-014516-r59usk02 682 5 revealed reveal VBD cord-014516-r59usk02 682 6 massive massive JJ cord-014516-r59usk02 682 7 deposition deposition NN cord-014516-r59usk02 682 8 of of IN cord-014516-r59usk02 682 9 porphyrins porphyrin NNS cord-014516-r59usk02 682 10 in in IN cord-014516-r59usk02 682 11 all all DT cord-014516-r59usk02 682 12 bones bone NNS cord-014516-r59usk02 682 13 and and CC cord-014516-r59usk02 682 14 teeth tooth NNS cord-014516-r59usk02 682 15 . . . cord-014516-r59usk02 683 1 Urine urine NN cord-014516-r59usk02 683 2 and and CC cord-014516-r59usk02 683 3 EDTA EDTA NNP cord-014516-r59usk02 683 4 blood blood NN cord-014516-r59usk02 683 5 samples sample NNS cord-014516-r59usk02 683 6 from from IN cord-014516-r59usk02 683 7 one one CD cord-014516-r59usk02 683 8 cat cat NN cord-014516-r59usk02 683 9 were be VBD cord-014516-r59usk02 683 10 metabolically metabolically RB cord-014516-r59usk02 683 11 studied study VBN cord-014516-r59usk02 683 12 , , , cord-014516-r59usk02 683 13 while while IN cord-014516-r59usk02 683 14 molecular molecular JJ cord-014516-r59usk02 683 15 genetic genetic JJ cord-014516-r59usk02 683 16 studies study NNS cord-014516-r59usk02 683 17 were be VBD cord-014516-r59usk02 683 18 performed perform VBN cord-014516-r59usk02 683 19 in in IN cord-014516-r59usk02 683 20 all all DT cord-014516-r59usk02 683 21 cats cat NNS cord-014516-r59usk02 683 22 either either CC cord-014516-r59usk02 683 23 from from IN cord-014516-r59usk02 683 24 EDTA EDTA NNP cord-014516-r59usk02 683 25 blood blood NN cord-014516-r59usk02 683 26 or or CC cord-014516-r59usk02 683 27 a a DT cord-014516-r59usk02 683 28 formalinized formalinized JJ cord-014516-r59usk02 683 29 splenic splenic JJ cord-014516-r59usk02 683 30 tissue tissue NN cord-014516-r59usk02 683 31 block block NN cord-014516-r59usk02 683 32 . . . cord-014516-r59usk02 684 1 Urinary urinary JJ cord-014516-r59usk02 684 2 d d NN cord-014516-r59usk02 684 3 - - HYPH cord-014516-r59usk02 684 4 aminolevulinic aminolevulinic JJ cord-014516-r59usk02 684 5 acid acid NN cord-014516-r59usk02 684 6 , , , cord-014516-r59usk02 684 7 porphobilinogen porphobilinogen NNP cord-014516-r59usk02 684 8 , , , cord-014516-r59usk02 684 9 uroporphyrin uroporphyrin NNP cord-014516-r59usk02 684 10 I I NNP cord-014516-r59usk02 684 11 , , , cord-014516-r59usk02 684 12 and and CC cord-014516-r59usk02 684 13 coproporphyrin coproporphyrin NNP cord-014516-r59usk02 685 1 I -PRON- PRP cord-014516-r59usk02 685 2 concentrations concentration NNS cord-014516-r59usk02 685 3 were be VBD cord-014516-r59usk02 685 4 increased increase VBN cord-014516-r59usk02 685 5 in in IN cord-014516-r59usk02 685 6 the the DT cord-014516-r59usk02 685 7 cat cat NN cord-014516-r59usk02 685 8 studied study VBD cord-014516-r59usk02 685 9 , , , cord-014516-r59usk02 685 10 suggesting suggest VBG cord-014516-r59usk02 685 11 an an DT cord-014516-r59usk02 685 12 acute acute JJ cord-014516-r59usk02 685 13 intermittent intermittent JJ cord-014516-r59usk02 685 14 porphyria porphyria NN cord-014516-r59usk02 685 15 ( ( -LRB- cord-014516-r59usk02 685 16 AIP AIP NNP cord-014516-r59usk02 685 17 ) ) -RRB- cord-014516-r59usk02 685 18 . . . cord-014516-r59usk02 686 1 The the DT cord-014516-r59usk02 686 2 erythrocytic erythrocytic JJ cord-014516-r59usk02 686 3 hydroxymethylbilane hydroxymethylbilane NNP cord-014516-r59usk02 686 4 synthase synthase NN cord-014516-r59usk02 686 5 ( ( -LRB- cord-014516-r59usk02 686 6 HMBS HMBS NNP cord-014516-r59usk02 686 7 ) ) -RRB- cord-014516-r59usk02 686 8 activity activity NN cord-014516-r59usk02 686 9 in in IN cord-014516-r59usk02 686 10 erythrocytes erythrocyte NNS cord-014516-r59usk02 686 11 was be VBD cord-014516-r59usk02 686 12 approximately approximately RB cord-014516-r59usk02 686 13 half half NN cord-014516-r59usk02 686 14 normal normal JJ cord-014516-r59usk02 686 15 suggesting suggest VBG cord-014516-r59usk02 686 16 a a DT cord-014516-r59usk02 686 17 dominant dominant JJ cord-014516-r59usk02 686 18 enzymopathy enzymopathy NNP cord-014516-r59usk02 686 19 , , , cord-014516-r59usk02 686 20 while while IN cord-014516-r59usk02 686 21 the the DT cord-014516-r59usk02 686 22 erythrocyte erythrocyte NN cord-014516-r59usk02 686 23 uroporphyrinogen uroporphyrinogen NNP cord-014516-r59usk02 686 24 IIIsynthase IIIsynthase NNP cord-014516-r59usk02 686 25 activity activity NN cord-014516-r59usk02 686 26 was be VBD cord-014516-r59usk02 686 27 normal normal JJ cord-014516-r59usk02 686 28 . . . cord-014516-r59usk02 687 1 Sequencing sequence VBG cord-014516-r59usk02 687 2 the the DT cord-014516-r59usk02 687 3 feline feline JJ cord-014516-r59usk02 687 4 HMBS HMBS NNP cord-014516-r59usk02 687 5 gene gene NN cord-014516-r59usk02 687 6 revealed reveal VBD cord-014516-r59usk02 687 7 a a DT cord-014516-r59usk02 687 8 heterozygous heterozygous JJ cord-014516-r59usk02 687 9 intronic intronic NNP cord-014516-r59usk02 687 10 12 12 CD cord-014516-r59usk02 687 11 base base NN cord-014516-r59usk02 687 12 deletion deletion NN cord-014516-r59usk02 687 13 ( ( -LRB- cord-014516-r59usk02 687 14 c.772 c.772 NNP cord-014516-r59usk02 687 15 - - HYPH cord-014516-r59usk02 687 16 13_-2del 13_-2del CD cord-014516-r59usk02 687 17 ) ) -RRB- cord-014516-r59usk02 687 18 which which WDT cord-014516-r59usk02 687 19 results result VBZ cord-014516-r59usk02 687 20 in in IN cord-014516-r59usk02 687 21 an an DT cord-014516-r59usk02 687 22 insertion insertion NN cord-014516-r59usk02 687 23 in in IN cord-014516-r59usk02 687 24 the the DT cord-014516-r59usk02 687 25 mRNA mrna NN cord-014516-r59usk02 687 26 and and CC cord-014516-r59usk02 687 27 would would MD cord-014516-r59usk02 687 28 predict predict VB cord-014516-r59usk02 687 29 a a DT cord-014516-r59usk02 687 30 truncated truncated JJ cord-014516-r59usk02 687 31 protein protein NN cord-014516-r59usk02 687 32 . . . cord-014516-r59usk02 688 1 In in IN cord-014516-r59usk02 688 2 conclusion conclusion NN cord-014516-r59usk02 688 3 , , , cord-014516-r59usk02 688 4 these these DT cord-014516-r59usk02 688 5 three three CD cord-014516-r59usk02 688 6 domestic domestic JJ cord-014516-r59usk02 688 7 shorthair shorthair JJ cord-014516-r59usk02 688 8 cats cat NNS cord-014516-r59usk02 688 9 had have VBD cord-014516-r59usk02 688 10 the the DT cord-014516-r59usk02 688 11 same same JJ cord-014516-r59usk02 688 12 HMBS HMBS NNP cord-014516-r59usk02 688 13 mutation mutation NN cord-014516-r59usk02 688 14 causing cause VBG cord-014516-r59usk02 688 15 an an DT cord-014516-r59usk02 688 16 autosomal autosomal JJ cord-014516-r59usk02 688 17 dominantly dominantly RB cord-014516-r59usk02 688 18 inherited inherit VBN cord-014516-r59usk02 688 19 AIP AIP NNP cord-014516-r59usk02 688 20 . . . cord-014516-r59usk02 689 1 Cats cat NNS cord-014516-r59usk02 689 2 with with IN cord-014516-r59usk02 689 3 discolored discolored JJ cord-014516-r59usk02 689 4 teeth tooth NNS cord-014516-r59usk02 689 5 and and CC cord-014516-r59usk02 689 6 normal normal JJ cord-014516-r59usk02 689 7 or or CC cord-014516-r59usk02 689 8 mild mild JJ cord-014516-r59usk02 689 9 hemolysis hemolysis NN cord-014516-r59usk02 689 10 may may MD cord-014516-r59usk02 689 11 have have VB cord-014516-r59usk02 689 12 either either CC cord-014516-r59usk02 689 13 acute acute JJ cord-014516-r59usk02 689 14 intermittent intermittent JJ cord-014516-r59usk02 689 15 porphyria porphyria NN cord-014516-r59usk02 689 16 or or CC cord-014516-r59usk02 689 17 congenital congenital JJ cord-014516-r59usk02 689 18 erythroid erythroid NN cord-014516-r59usk02 689 19 porphyria porphyria NN cord-014516-r59usk02 689 20 . . . cord-014516-r59usk02 690 1 Interestingly interestingly RB cord-014516-r59usk02 690 2 , , , cord-014516-r59usk02 690 3 seven seven CD cord-014516-r59usk02 690 4 disease disease NN cord-014516-r59usk02 690 5 - - HYPH cord-014516-r59usk02 690 6 causing cause VBG cord-014516-r59usk02 690 7 mutations mutation NNS cord-014516-r59usk02 690 8 have have VBP cord-014516-r59usk02 690 9 now now RB cord-014516-r59usk02 690 10 been be VBN cord-014516-r59usk02 690 11 found find VBN cord-014516-r59usk02 690 12 by by IN cord-014516-r59usk02 690 13 us -PRON- PRP cord-014516-r59usk02 690 14 in in IN cord-014516-r59usk02 690 15 the the DT cord-014516-r59usk02 690 16 HMBS HMBS NNP cord-014516-r59usk02 690 17 gene gene NN cord-014516-r59usk02 690 18 -more -more . cord-014516-r59usk02 691 1 than than IN cord-014516-r59usk02 691 2 in in IN cord-014516-r59usk02 691 3 any any DT cord-014516-r59usk02 691 4 other other JJ cord-014516-r59usk02 691 5 gene gene NN cord-014516-r59usk02 691 6 in in IN cord-014516-r59usk02 691 7 cats cat NNS cord-014516-r59usk02 691 8 . . . cord-014516-r59usk02 692 1 The the DT cord-014516-r59usk02 692 2 biochemical biochemical JJ cord-014516-r59usk02 692 3 and and CC cord-014516-r59usk02 692 4 molecular molecular JJ cord-014516-r59usk02 692 5 characterization characterization NN cord-014516-r59usk02 692 6 facilitates facilitate VBZ cord-014516-r59usk02 692 7 clinical clinical JJ cord-014516-r59usk02 692 8 screening screening NN cord-014516-r59usk02 692 9 of of IN cord-014516-r59usk02 692 10 affected affected JJ cord-014516-r59usk02 692 11 cats cat NNS cord-014516-r59usk02 692 12 to to TO cord-014516-r59usk02 692 13 reach reach VB cord-014516-r59usk02 692 14 a a DT cord-014516-r59usk02 692 15 specific specific JJ cord-014516-r59usk02 692 16 diagnosis diagnosis NN cord-014516-r59usk02 692 17 . . . cord-014516-r59usk02 693 1 Supported support VBN cord-014516-r59usk02 693 2 in in IN cord-014516-r59usk02 693 3 part part NN cord-014516-r59usk02 693 4 by by IN cord-014516-r59usk02 693 5 NIH NIH NNP cord-014516-r59usk02 693 6 OD OD NNP cord-014516-r59usk02 693 7 010939 010939 CD cord-014516-r59usk02 693 8 . . . cord-014516-r59usk02 694 1 Urs Urs NNP cord-014516-r59usk02 694 2 Giger Giger NNP cord-014516-r59usk02 694 3 and and CC cord-014516-r59usk02 694 4 Raj Raj NNP cord-014516-r59usk02 694 5 Karthik Karthik NNP cord-014516-r59usk02 694 6 are be VBP cord-014516-r59usk02 694 7 also also RB cord-014516-r59usk02 694 8 part part NN cord-014516-r59usk02 694 9 of of IN cord-014516-r59usk02 694 10 the the DT cord-014516-r59usk02 694 11 laboratory laboratory NN cord-014516-r59usk02 694 12 that that WDT cord-014516-r59usk02 694 13 offers offer VBZ cord-014516-r59usk02 694 14 DNA dna NN cord-014516-r59usk02 694 15 testing testing NN cord-014516-r59usk02 694 16 for for IN cord-014516-r59usk02 694 17 this this DT cord-014516-r59usk02 694 18 mutation mutation NN cord-014516-r59usk02 694 19 . . . cord-014516-r59usk02 695 1 Fibrinogen fibrinogen NN cord-014516-r59usk02 695 2 decreases decrease VBZ cord-014516-r59usk02 695 3 when when WRB cord-014516-r59usk02 695 4 coagulation coagulation NN cord-014516-r59usk02 695 5 is be VBZ cord-014516-r59usk02 695 6 activated activate VBN cord-014516-r59usk02 695 7 to to TO cord-014516-r59usk02 695 8 form form VB cord-014516-r59usk02 695 9 fibrin fibrin NN cord-014516-r59usk02 695 10 , , , cord-014516-r59usk02 695 11 while while IN cord-014516-r59usk02 695 12 FDPs fdp NNS cord-014516-r59usk02 695 13 and and CC cord-014516-r59usk02 695 14 D D NNS cord-014516-r59usk02 695 15 - - HYPH cord-014516-r59usk02 695 16 dimers dimer NNS cord-014516-r59usk02 695 17 represent represent VBP cord-014516-r59usk02 695 18 the the DT cord-014516-r59usk02 695 19 products product NNS cord-014516-r59usk02 695 20 of of IN cord-014516-r59usk02 695 21 fibrinolysis fibrinolysis NN cord-014516-r59usk02 695 22 . . . cord-014516-r59usk02 696 1 In in IN cord-014516-r59usk02 696 2 humans human NNS cord-014516-r59usk02 696 3 , , , cord-014516-r59usk02 696 4 activation activation NN cord-014516-r59usk02 696 5 of of IN cord-014516-r59usk02 696 6 coagulation coagulation NN cord-014516-r59usk02 696 7 and and CC cord-014516-r59usk02 696 8 fibrinolysis fibrinolysis NN cord-014516-r59usk02 696 9 develops develop VBZ cord-014516-r59usk02 696 10 in in IN cord-014516-r59usk02 696 11 all all DT cord-014516-r59usk02 696 12 type type NN cord-014516-r59usk02 696 13 of of IN cord-014516-r59usk02 696 14 ascites ascites NN cord-014516-r59usk02 696 15 and and CC cord-014516-r59usk02 696 16 it -PRON- PRP cord-014516-r59usk02 696 17 is be VBZ cord-014516-r59usk02 696 18 also also RB cord-014516-r59usk02 696 19 associated associate VBN cord-014516-r59usk02 696 20 with with IN cord-014516-r59usk02 696 21 signs sign NNS cord-014516-r59usk02 696 22 of of IN cord-014516-r59usk02 696 23 systemic systemic JJ cord-014516-r59usk02 696 24 fibrinolysis fibrinolysis NN cord-014516-r59usk02 696 25 . . . cord-014516-r59usk02 697 1 These these DT cord-014516-r59usk02 697 2 results result NNS cord-014516-r59usk02 697 3 have have VBP cord-014516-r59usk02 697 4 lead lead NN cord-014516-r59usk02 697 5 to to IN cord-014516-r59usk02 697 6 the the DT cord-014516-r59usk02 697 7 suggestion suggestion NN cord-014516-r59usk02 697 8 that that IN cord-014516-r59usk02 697 9 ascitic ascitic JJ cord-014516-r59usk02 697 10 fluid fluid NN cord-014516-r59usk02 697 11 is be VBZ cord-014516-r59usk02 697 12 inherently inherently RB cord-014516-r59usk02 697 13 fibrinolytic fibrinolytic JJ cord-014516-r59usk02 697 14 . . . cord-014516-r59usk02 698 1 Preliminary preliminary JJ cord-014516-r59usk02 698 2 studies study NNS cord-014516-r59usk02 698 3 showed show VBD cord-014516-r59usk02 698 4 similar similar JJ cord-014516-r59usk02 698 5 results result NNS cord-014516-r59usk02 698 6 also also RB cord-014516-r59usk02 698 7 in in IN cord-014516-r59usk02 698 8 dogs dog NNS cord-014516-r59usk02 698 9 ( ( -LRB- cord-014516-r59usk02 698 10 JAVMA JAVMA NNP cord-014516-r59usk02 698 11 Nov. November NNP cord-014516-r59usk02 698 12 2012 2012 CD cord-014516-r59usk02 698 13 , , , cord-014516-r59usk02 698 14 ECVIM ecvim NN cord-014516-r59usk02 698 15 proceedings proceeding NNS cord-014516-r59usk02 698 16 2013 2013 CD cord-014516-r59usk02 698 17 . . . cord-014516-r59usk02 699 1 In in IN cord-014516-r59usk02 699 2 addition addition NN cord-014516-r59usk02 699 3 , , , cord-014516-r59usk02 699 4 in in IN cord-014516-r59usk02 699 5 an an DT cord-014516-r59usk02 699 6 old old JJ cord-014516-r59usk02 699 7 experimental experimental JJ cord-014516-r59usk02 699 8 study study NN cord-014516-r59usk02 699 9 conducted conduct VBN cord-014516-r59usk02 699 10 in in IN cord-014516-r59usk02 699 11 dogs dog NNS cord-014516-r59usk02 699 12 , , , cord-014516-r59usk02 699 13 inoculation inoculation NN cord-014516-r59usk02 699 14 of of IN cord-014516-r59usk02 699 15 blood blood NN cord-014516-r59usk02 699 16 or or CC cord-014516-r59usk02 699 17 of of IN cord-014516-r59usk02 699 18 a a DT cord-014516-r59usk02 699 19 solution solution NN cord-014516-r59usk02 699 20 containing contain VBG cord-014516-r59usk02 699 21 fibrinogen fibrinogen NN cord-014516-r59usk02 699 22 and and CC cord-014516-r59usk02 699 23 thrombin thrombin NN cord-014516-r59usk02 699 24 into into IN cord-014516-r59usk02 699 25 the the DT cord-014516-r59usk02 699 26 pleural pleural JJ cord-014516-r59usk02 699 27 cavity cavity NN cord-014516-r59usk02 699 28 resulted result VBD cord-014516-r59usk02 699 29 in in IN cord-014516-r59usk02 699 30 the the DT cord-014516-r59usk02 699 31 activation activation NN cord-014516-r59usk02 699 32 of of IN cord-014516-r59usk02 699 33 the the DT cord-014516-r59usk02 699 34 coagulation coagulation NN cord-014516-r59usk02 699 35 system system NN cord-014516-r59usk02 699 36 followed follow VBN cord-014516-r59usk02 699 37 by by IN cord-014516-r59usk02 699 38 fibrinolysis fibrinolysis NNP cord-014516-r59usk02 699 39 . . . cord-014516-r59usk02 700 1 Therefore therefore RB cord-014516-r59usk02 700 2 , , , cord-014516-r59usk02 700 3 the the DT cord-014516-r59usk02 700 4 objective objective NN cord-014516-r59usk02 700 5 of of IN cord-014516-r59usk02 700 6 the the DT cord-014516-r59usk02 700 7 present present JJ cord-014516-r59usk02 700 8 study study NN cord-014516-r59usk02 700 9 was be VBD cord-014516-r59usk02 700 10 to to TO cord-014516-r59usk02 700 11 determine determine VB cord-014516-r59usk02 700 12 whether whether IN cord-014516-r59usk02 700 13 the the DT cord-014516-r59usk02 700 14 activation activation NN cord-014516-r59usk02 700 15 of of IN cord-014516-r59usk02 700 16 coagulation coagulation NN cord-014516-r59usk02 700 17 and and CC cord-014516-r59usk02 700 18 fibrinolysis fibrinolysis NN cord-014516-r59usk02 700 19 ( ( -LRB- cord-014516-r59usk02 700 20 i.e. i.e. FW cord-014516-r59usk02 700 21 low low JJ cord-014516-r59usk02 700 22 fibrinogen fibrinogen NN cord-014516-r59usk02 700 23 and and CC cord-014516-r59usk02 700 24 elevated elevated JJ cord-014516-r59usk02 700 25 FDPs fdp NNS cord-014516-r59usk02 700 26 and and CC cord-014516-r59usk02 700 27 Ddimer Ddimer NNP cord-014516-r59usk02 700 28 ) ) -RRB- cord-014516-r59usk02 700 29 occurs occur VBZ cord-014516-r59usk02 700 30 not not RB cord-014516-r59usk02 700 31 only only RB cord-014516-r59usk02 700 32 in in IN cord-014516-r59usk02 700 33 the the DT cord-014516-r59usk02 700 34 ascitic ascitic JJ cord-014516-r59usk02 700 35 fluid fluid NN cord-014516-r59usk02 700 36 , , , cord-014516-r59usk02 700 37 as as IN cord-014516-r59usk02 700 38 alredy alredy RB cord-014516-r59usk02 700 39 been be VBN cord-014516-r59usk02 700 40 demonstrated demonstrate VBN cord-014516-r59usk02 700 41 , , , cord-014516-r59usk02 700 42 but but CC cord-014516-r59usk02 700 43 also also RB cord-014516-r59usk02 700 44 in in IN cord-014516-r59usk02 700 45 all all DT cord-014516-r59usk02 700 46 type type NN cord-014516-r59usk02 700 47 of of IN cord-014516-r59usk02 700 48 pleural pleural JJ cord-014516-r59usk02 700 49 effusions effusion NNS cord-014516-r59usk02 700 50 in in IN cord-014516-r59usk02 700 51 dogs dog NNS cord-014516-r59usk02 700 52 . . . cord-014516-r59usk02 701 1 Thirty thirty CD cord-014516-r59usk02 701 2 - - HYPH cord-014516-r59usk02 701 3 three three CD cord-014516-r59usk02 701 4 dogs dog NNS cord-014516-r59usk02 701 5 referred refer VBD cord-014516-r59usk02 701 6 to to IN cord-014516-r59usk02 701 7 the the DT cord-014516-r59usk02 701 8 San San NNP cord-014516-r59usk02 701 9 Marco Marco NNP cord-014516-r59usk02 701 10 Veterinary Veterinary NNP cord-014516-r59usk02 701 11 Clinic Clinic NNP cord-014516-r59usk02 701 12 with with IN cord-014516-r59usk02 701 13 pleural pleural JJ cord-014516-r59usk02 701 14 effusion effusion NN cord-014516-r59usk02 701 15 , , , cord-014516-r59usk02 701 16 but but CC cord-014516-r59usk02 701 17 without without IN cord-014516-r59usk02 701 18 ascites ascites NN cord-014516-r59usk02 701 19 , , , cord-014516-r59usk02 701 20 were be VBD cord-014516-r59usk02 701 21 studied study VBN cord-014516-r59usk02 701 22 . . . cord-014516-r59usk02 702 1 Fibrinogen fibrinogen NN cord-014516-r59usk02 702 2 , , , cord-014516-r59usk02 702 3 FDPs fdp NNS cord-014516-r59usk02 702 4 , , , cord-014516-r59usk02 702 5 and and CC cord-014516-r59usk02 702 6 D d NN cord-014516-r59usk02 702 7 - - HYPH cord-014516-r59usk02 702 8 dimer dimer NN cord-014516-r59usk02 702 9 concentrations concentration NNS cord-014516-r59usk02 702 10 were be VBD cord-014516-r59usk02 702 11 measured measure VBN cord-014516-r59usk02 702 12 and and CC cord-014516-r59usk02 702 13 then then RB cord-014516-r59usk02 702 14 compared compare VBN cord-014516-r59usk02 702 15 in in IN cord-014516-r59usk02 702 16 both both DT cord-014516-r59usk02 702 17 pleural pleural JJ cord-014516-r59usk02 702 18 fluid fluid NN cord-014516-r59usk02 702 19 and and CC cord-014516-r59usk02 702 20 venous venous JJ cord-014516-r59usk02 702 21 blood blood NN cord-014516-r59usk02 702 22 via via IN cord-014516-r59usk02 702 23 Wilcoxon Wilcoxon NNP cord-014516-r59usk02 702 24 signed sign VBD cord-014516-r59usk02 702 25 ranks rank NNS cord-014516-r59usk02 702 26 test test NN cord-014516-r59usk02 702 27 . . . cord-014516-r59usk02 703 1 The the DT cord-014516-r59usk02 703 2 dog dog NN cord-014516-r59usk02 703 3 's 's POS cord-014516-r59usk02 703 4 pleural pleural JJ cord-014516-r59usk02 703 5 effusions effusion NNS cord-014516-r59usk02 703 6 were be VBD cord-014516-r59usk02 703 7 categorized categorize VBN cord-014516-r59usk02 703 8 based base VBN cord-014516-r59usk02 703 9 on on IN cord-014516-r59usk02 703 10 pathophysiology pathophysiology NN cord-014516-r59usk02 703 11 of of IN cord-014516-r59usk02 703 12 fluid fluid JJ cord-014516-r59usk02 703 13 formation formation NN cord-014516-r59usk02 703 14 into into IN cord-014516-r59usk02 703 15 5 5 CD cord-014516-r59usk02 703 16 dogs dog NNS cord-014516-r59usk02 703 17 with with IN cord-014516-r59usk02 703 18 transudate transudate NN cord-014516-r59usk02 703 19 ( ( -LRB- cord-014516-r59usk02 703 20 4 4 CD cord-014516-r59usk02 703 21 due due JJ cord-014516-r59usk02 703 22 to to IN cord-014516-r59usk02 703 23 increased increase VBN cord-014516-r59usk02 703 24 hydrostatic hydrostatic JJ cord-014516-r59usk02 703 25 pressure pressure NN cord-014516-r59usk02 703 26 and and CC cord-014516-r59usk02 703 27 1 1 CD cord-014516-r59usk02 703 28 due due JJ cord-014516-r59usk02 703 29 to to IN cord-014516-r59usk02 703 30 decreased decrease VBN cord-014516-r59usk02 703 31 osmotic osmotic JJ cord-014516-r59usk02 703 32 pressure pressure NN cord-014516-r59usk02 703 33 ) ) -RRB- cord-014516-r59usk02 703 34 , , , cord-014516-r59usk02 703 35 23 23 CD cord-014516-r59usk02 703 36 with with IN cord-014516-r59usk02 703 37 an an DT cord-014516-r59usk02 703 38 exudate exudate NN cord-014516-r59usk02 703 39 ( ( -LRB- cord-014516-r59usk02 703 40 of of IN cord-014516-r59usk02 703 41 which which WDT cord-014516-r59usk02 703 42 11 11 CD cord-014516-r59usk02 703 43 due due JJ cord-014516-r59usk02 703 44 to to IN cord-014516-r59usk02 703 45 septic septic JJ cord-014516-r59usk02 703 46 causes cause NNS cord-014516-r59usk02 703 47 ) ) -RRB- cord-014516-r59usk02 703 48 , , , cord-014516-r59usk02 703 49 4 4 CD cord-014516-r59usk02 703 50 with with IN cord-014516-r59usk02 703 51 a a DT cord-014516-r59usk02 703 52 haemorrhagic haemorrhagic JJ cord-014516-r59usk02 703 53 pleural pleural JJ cord-014516-r59usk02 703 54 effusion effusion NN cord-014516-r59usk02 703 55 , , , cord-014516-r59usk02 703 56 and and CC cord-014516-r59usk02 703 57 4 4 CD cord-014516-r59usk02 703 58 with with IN cord-014516-r59usk02 703 59 a a DT cord-014516-r59usk02 703 60 chylous chylous JJ cord-014516-r59usk02 703 61 effusions effusion NNS cord-014516-r59usk02 703 62 . . . cord-014516-r59usk02 704 1 The the DT cord-014516-r59usk02 704 2 fibrinogen fibrinogen NN cord-014516-r59usk02 704 3 concentration concentration NN cord-014516-r59usk02 704 4 in in IN cord-014516-r59usk02 704 5 the the DT cord-014516-r59usk02 704 6 pleural pleural JJ cord-014516-r59usk02 704 7 effusion effusion NN cord-014516-r59usk02 704 8 ( ( -LRB- cord-014516-r59usk02 704 9 median median NN cord-014516-r59usk02 704 10 : : : cord-014516-r59usk02 704 11 59 59 CD cord-014516-r59usk02 704 12 mg mg NNP cord-014516-r59usk02 704 13 / / SYM cord-014516-r59usk02 704 14 dL dl NN cord-014516-r59usk02 704 15 ; ; : cord-014516-r59usk02 704 16 range range NN cord-014516-r59usk02 704 17 : : : cord-014516-r59usk02 704 18 59 59 CD cord-014516-r59usk02 704 19 - - SYM cord-014516-r59usk02 704 20 59 59 CD cord-014516-r59usk02 704 21 ) ) -RRB- cord-014516-r59usk02 704 22 was be VBD cord-014516-r59usk02 704 23 significantly significantly RB cord-014516-r59usk02 704 24 lower low JJR cord-014516-r59usk02 704 25 ( ( -LRB- cord-014516-r59usk02 704 26 p p NN cord-014516-r59usk02 704 27 < < XX cord-014516-r59usk02 704 28 0.0001 0.0001 CD cord-014516-r59usk02 704 29 ) ) -RRB- cord-014516-r59usk02 704 30 than than IN cord-014516-r59usk02 704 31 the the DT cord-014516-r59usk02 704 32 plasma plasma NN cord-014516-r59usk02 704 33 fibrinogen fibrinogen NN cord-014516-r59usk02 704 34 concentration concentration NN cord-014516-r59usk02 704 35 ( ( -LRB- cord-014516-r59usk02 704 36 median median NN cord-014516-r59usk02 704 37 : : : cord-014516-r59usk02 704 38 419 419 CD cord-014516-r59usk02 704 39 mg mg NNP cord-014516-r59usk02 704 40 / / SYM cord-014516-r59usk02 704 41 dL dl NN cord-014516-r59usk02 704 42 ; ; : cord-014516-r59usk02 705 1 range range NN cord-014516-r59usk02 705 2 : : : cord-014516-r59usk02 705 3 131 131 CD cord-014516-r59usk02 705 4 - - SYM cord-014516-r59usk02 705 5 1406 1406 CD cord-014516-r59usk02 705 6 ) ) -RRB- cord-014516-r59usk02 705 7 . . . cord-014516-r59usk02 706 1 In in IN cord-014516-r59usk02 706 2 all all DT cord-014516-r59usk02 706 3 dogs dog NNS cord-014516-r59usk02 706 4 , , , cord-014516-r59usk02 706 5 the the DT cord-014516-r59usk02 706 6 fibrinogen fibrinogen NN cord-014516-r59usk02 706 7 pleural pleural JJ cord-014516-r59usk02 706 8 fluid fluid NN cord-014516-r59usk02 706 9 concentration concentration NN cord-014516-r59usk02 706 10 was be VBD cord-014516-r59usk02 706 11 lower low JJR cord-014516-r59usk02 706 12 than than IN cord-014516-r59usk02 706 13 the the DT cord-014516-r59usk02 706 14 plasma plasma NN cord-014516-r59usk02 706 15 concentration concentration NN cord-014516-r59usk02 706 16 . . . cord-014516-r59usk02 707 1 The the DT cord-014516-r59usk02 707 2 FDP FDP NNP cord-014516-r59usk02 707 3 concentration concentration NN cord-014516-r59usk02 707 4 in in IN cord-014516-r59usk02 707 5 the the DT cord-014516-r59usk02 707 6 pleural pleural JJ cord-014516-r59usk02 707 7 effusion effusion NN cord-014516-r59usk02 707 8 ( ( -LRB- cord-014516-r59usk02 707 9 median median NN cord-014516-r59usk02 707 10 : : : cord-014516-r59usk02 707 11 151 151 CD cord-014516-r59usk02 707 12 mg mg NNP cord-014516-r59usk02 707 13 / / SYM cord-014516-r59usk02 707 14 dL dl NN cord-014516-r59usk02 707 15 ; ; : cord-014516-r59usk02 707 16 range range NN cord-014516-r59usk02 707 17 : : : cord-014516-r59usk02 707 18 0.69 0.69 CD cord-014516-r59usk02 707 19 - - SYM cord-014516-r59usk02 707 20 151 151 CD cord-014516-r59usk02 707 21 ) ) -RRB- cord-014516-r59usk02 707 22 was be VBD cord-014516-r59usk02 707 23 significantly significantly RB cord-014516-r59usk02 707 24 ( ( -LRB- cord-014516-r59usk02 707 25 p p NN cord-014516-r59usk02 707 26 < < XX cord-014516-r59usk02 707 27 0.0001 0.0001 CD cord-014516-r59usk02 707 28 ) ) -RRB- cord-014516-r59usk02 707 29 higher high JJR cord-014516-r59usk02 707 30 than than IN cord-014516-r59usk02 707 31 plasma plasma NN cord-014516-r59usk02 707 32 FDPs fdp NNS cord-014516-r59usk02 707 33 concentrations concentration NNS cord-014516-r59usk02 707 34 ( ( -LRB- cord-014516-r59usk02 707 35 median median NN cord-014516-r59usk02 707 36 : : : cord-014516-r59usk02 707 37 5.55 5.55 CD cord-014516-r59usk02 707 38 mg mg NNP cord-014516-r59usk02 707 39 / / SYM cord-014516-r59usk02 707 40 dL dl NN cord-014516-r59usk02 707 41 ; ; : cord-014516-r59usk02 707 42 range range NN cord-014516-r59usk02 707 43 : : : cord-014516-r59usk02 707 44 0.83 0.83 CD cord-014516-r59usk02 707 45 - - HYPH cord-014516-r59usk02 707 46 108.47 108.47 CD cord-014516-r59usk02 707 47 ) ) -RRB- cord-014516-r59usk02 707 48 . . . cord-014516-r59usk02 708 1 In in IN cord-014516-r59usk02 708 2 1 1 CD cord-014516-r59usk02 708 3 case case NN cord-014516-r59usk02 708 4 , , , cord-014516-r59usk02 708 5 the the DT cord-014516-r59usk02 708 6 FDPs fdp NNS cord-014516-r59usk02 708 7 pleural pleural JJ cord-014516-r59usk02 708 8 fluid fluid JJ cord-014516-r59usk02 708 9 concentration concentration NN cord-014516-r59usk02 708 10 was be VBD cord-014516-r59usk02 708 11 lower low JJR cord-014516-r59usk02 708 12 than than IN cord-014516-r59usk02 708 13 the the DT cord-014516-r59usk02 708 14 plasma plasma NN cord-014516-r59usk02 708 15 concentration concentration NN cord-014516-r59usk02 708 16 and and CC cord-014516-r59usk02 708 17 in in IN cord-014516-r59usk02 708 18 32 32 CD cord-014516-r59usk02 708 19 cases case NNS cord-014516-r59usk02 708 20 the the DT cord-014516-r59usk02 708 21 pleural pleural JJ cord-014516-r59usk02 708 22 fluid fluid JJ cord-014516-r59usk02 708 23 concentration concentration NN cord-014516-r59usk02 708 24 was be VBD cord-014516-r59usk02 708 25 higher high JJR cord-014516-r59usk02 708 26 . . . cord-014516-r59usk02 709 1 The the DT cord-014516-r59usk02 709 2 D d NN cord-014516-r59usk02 709 3 - - HYPH cord-014516-r59usk02 709 4 dimer dimer NN cord-014516-r59usk02 709 5 concentrations concentration NNS cord-014516-r59usk02 709 6 were be VBD cord-014516-r59usk02 709 7 significantly(p significantly(p NNP cord-014516-r59usk02 710 1 < < NNP cord-014516-r59usk02 710 2 0.0001 0.0001 CD cord-014516-r59usk02 710 3 ) ) -RRB- cord-014516-r59usk02 710 4 higher high JJR cord-014516-r59usk02 710 5 in in IN cord-014516-r59usk02 710 6 the the DT cord-014516-r59usk02 710 7 pleural pleural JJ cord-014516-r59usk02 710 8 effusion effusion NN cord-014516-r59usk02 710 9 ( ( -LRB- cord-014516-r59usk02 710 10 median median NN cord-014516-r59usk02 710 11 : : : cord-014516-r59usk02 710 12 3.84 3.84 CD cord-014516-r59usk02 710 13 lg lg NNP cord-014516-r59usk02 710 14 / / SYM cord-014516-r59usk02 710 15 mL ml NN cord-014516-r59usk02 710 16 ; ; : cord-014516-r59usk02 711 1 range range NN cord-014516-r59usk02 711 2 : : : cord-014516-r59usk02 711 3 0.05 0.05 CD cord-014516-r59usk02 711 4 - - HYPH cord-014516-r59usk02 711 5 9.61 9.61 CD cord-014516-r59usk02 711 6 ) ) -RRB- cord-014516-r59usk02 711 7 than than IN cord-014516-r59usk02 711 8 in in IN cord-014516-r59usk02 711 9 the the DT cord-014516-r59usk02 711 10 plasma plasma NN cord-014516-r59usk02 712 1 ( ( -LRB- cord-014516-r59usk02 712 2 median median NN cord-014516-r59usk02 712 3 : : : cord-014516-r59usk02 712 4 0.07 0.07 CD cord-014516-r59usk02 712 5 lg lg NNP cord-014516-r59usk02 712 6 / / SYM cord-014516-r59usk02 712 7 mL ml NN cord-014516-r59usk02 712 8 ; ; : cord-014516-r59usk02 712 9 range range NN cord-014516-r59usk02 712 10 : : : cord-014516-r59usk02 712 11 0.01 0.01 CD cord-014516-r59usk02 712 12 - - HYPH cord-014516-r59usk02 712 13 7.67 7.67 CD cord-014516-r59usk02 712 14 ) ) -RRB- cord-014516-r59usk02 712 15 . . . cord-014516-r59usk02 713 1 In in IN cord-014516-r59usk02 713 2 one one CD cord-014516-r59usk02 713 3 case case NN cord-014516-r59usk02 713 4 , , , cord-014516-r59usk02 713 5 the the DT cord-014516-r59usk02 713 6 D d NN cord-014516-r59usk02 713 7 - - HYPH cord-014516-r59usk02 713 8 dimer dimer JJ cord-014516-r59usk02 713 9 pleural pleural JJ cord-014516-r59usk02 713 10 fluid fluid NN cord-014516-r59usk02 713 11 concentration concentration NN cord-014516-r59usk02 713 12 was be VBD cord-014516-r59usk02 713 13 lower low JJR cord-014516-r59usk02 713 14 than than IN cord-014516-r59usk02 713 15 the the DT cord-014516-r59usk02 713 16 plasma plasma NN cord-014516-r59usk02 713 17 concentration concentration NN cord-014516-r59usk02 713 18 and and CC cord-014516-r59usk02 713 19 in in IN cord-014516-r59usk02 713 20 32 32 CD cord-014516-r59usk02 713 21 cases case NNS cord-014516-r59usk02 713 22 was be VBD cord-014516-r59usk02 713 23 higher high JJR cord-014516-r59usk02 713 24 . . . cord-014516-r59usk02 714 1 These these DT cord-014516-r59usk02 714 2 findings finding NNS cord-014516-r59usk02 714 3 support support VBP cord-014516-r59usk02 714 4 the the DT cord-014516-r59usk02 714 5 hypothesis hypothesis NN cord-014516-r59usk02 714 6 that that DT cord-014516-r59usk02 714 7 activation activation NN cord-014516-r59usk02 714 8 of of IN cord-014516-r59usk02 714 9 coagulation coagulation NN cord-014516-r59usk02 714 10 followed follow VBN cord-014516-r59usk02 714 11 by by IN cord-014516-r59usk02 714 12 fibrinolysis fibrinolysis NN cord-014516-r59usk02 714 13 occurs occur VBZ cord-014516-r59usk02 714 14 in in IN cord-014516-r59usk02 714 15 all all DT cord-014516-r59usk02 714 16 type type NN cord-014516-r59usk02 714 17 of of IN cord-014516-r59usk02 714 18 pleural pleural JJ cord-014516-r59usk02 714 19 effusions effusion NNS cord-014516-r59usk02 714 20 . . . cord-014516-r59usk02 715 1 No no DT cord-014516-r59usk02 715 2 conflicts conflict NNS cord-014516-r59usk02 715 3 of of IN cord-014516-r59usk02 715 4 interest interest NN cord-014516-r59usk02 715 5 reported report VBN cord-014516-r59usk02 715 6 . . . cord-014516-r59usk02 716 1 During during IN cord-014516-r59usk02 716 2 primary primary JJ cord-014516-r59usk02 716 3 hyperfibrinogenolysis hyperfibrinogenolysis NN cord-014516-r59usk02 716 4 ( ( -LRB- cord-014516-r59usk02 716 5 PHF PHF NNP cord-014516-r59usk02 716 6 ) ) -RRB- cord-014516-r59usk02 716 7 , , , cord-014516-r59usk02 716 8 FDPs FDPs NNP cord-014516-r59usk02 716 9 production production NN cord-014516-r59usk02 716 10 is be VBZ cord-014516-r59usk02 716 11 increased increase VBN cord-014516-r59usk02 716 12 but but CC cord-014516-r59usk02 716 13 production production NN cord-014516-r59usk02 716 14 of of IN cord-014516-r59usk02 716 15 D d NN cord-014516-r59usk02 716 16 - - HYPH cord-014516-r59usk02 716 17 dimer dimer NN cord-014516-r59usk02 716 18 is be VBZ cord-014516-r59usk02 716 19 not not RB cord-014516-r59usk02 716 20 . . . cord-014516-r59usk02 717 1 Therefore therefore RB cord-014516-r59usk02 717 2 , , , cord-014516-r59usk02 717 3 elevated elevated JJ cord-014516-r59usk02 717 4 FDPs fdp NNS cord-014516-r59usk02 717 5 and and CC cord-014516-r59usk02 717 6 normal normal JJ cord-014516-r59usk02 717 7 D d NN cord-014516-r59usk02 717 8 - - HYPH cord-014516-r59usk02 717 9 dimer dimer NN cord-014516-r59usk02 717 10 are be VBP cord-014516-r59usk02 717 11 considered consider VBN cord-014516-r59usk02 717 12 an an DT cord-014516-r59usk02 717 13 indicator indicator NN cord-014516-r59usk02 717 14 of of IN cord-014516-r59usk02 717 15 PHF PHF NNP cord-014516-r59usk02 717 16 . . . cord-014516-r59usk02 718 1 In in IN cord-014516-r59usk02 718 2 humans human NNS cord-014516-r59usk02 718 3 and and CC cord-014516-r59usk02 718 4 dogs dog NNS cord-014516-r59usk02 718 5 , , , cord-014516-r59usk02 718 6 activation activation NN cord-014516-r59usk02 718 7 of of IN cord-014516-r59usk02 718 8 coagulation coagulation NN cord-014516-r59usk02 718 9 and and CC cord-014516-r59usk02 718 10 fibrinolysis fibrinolysis NN cord-014516-r59usk02 718 11 develops develop VBZ cord-014516-r59usk02 718 12 in in IN cord-014516-r59usk02 718 13 all all DT cord-014516-r59usk02 718 14 type type NN cord-014516-r59usk02 718 15 of of IN cord-014516-r59usk02 718 16 ascites ascites NN cord-014516-r59usk02 718 17 and and CC cord-014516-r59usk02 718 18 it -PRON- PRP cord-014516-r59usk02 718 19 is be VBZ cord-014516-r59usk02 718 20 associated associate VBN cord-014516-r59usk02 718 21 with with IN cord-014516-r59usk02 718 22 systemic systemic JJ cord-014516-r59usk02 718 23 PHF PHF NNP cord-014516-r59usk02 718 24 , , , cord-014516-r59usk02 718 25 suggesting suggest VBG cord-014516-r59usk02 718 26 that that IN cord-014516-r59usk02 718 27 ascitis ascitis NNP cord-014516-r59usk02 718 28 is be VBZ cord-014516-r59usk02 718 29 inherently inherently RB cord-014516-r59usk02 718 30 fibrinolytic fibrinolytic JJ cord-014516-r59usk02 718 31 . . . cord-014516-r59usk02 719 1 Preliminary preliminary JJ cord-014516-r59usk02 719 2 data datum NNS cord-014516-r59usk02 719 3 have have VBP cord-014516-r59usk02 719 4 shown show VBN cord-014516-r59usk02 719 5 that that DT cord-014516-r59usk02 719 6 activation activation NN cord-014516-r59usk02 719 7 of of IN cord-014516-r59usk02 719 8 coagulation coagulation NN cord-014516-r59usk02 719 9 followed follow VBN cord-014516-r59usk02 719 10 by by IN cord-014516-r59usk02 719 11 fibrinolysis fibrinolysis NN cord-014516-r59usk02 719 12 occurs occur VBZ cord-014516-r59usk02 719 13 also also RB cord-014516-r59usk02 719 14 in in IN cord-014516-r59usk02 719 15 all all DT cord-014516-r59usk02 719 16 type type NN cord-014516-r59usk02 719 17 of of IN cord-014516-r59usk02 719 18 pleural pleural JJ cord-014516-r59usk02 719 19 effusions effusion NNS cord-014516-r59usk02 719 20 ( ( -LRB- cord-014516-r59usk02 719 21 PE PE NNP cord-014516-r59usk02 719 22 ) ) -RRB- cord-014516-r59usk02 719 23 . . . cord-014516-r59usk02 720 1 The the DT cord-014516-r59usk02 720 2 objective objective NN cord-014516-r59usk02 720 3 of of IN cord-014516-r59usk02 720 4 this this DT cord-014516-r59usk02 720 5 study study NN cord-014516-r59usk02 720 6 was be VBD cord-014516-r59usk02 720 7 to to TO cord-014516-r59usk02 720 8 determine determine VB cord-014516-r59usk02 720 9 if if IN cord-014516-r59usk02 720 10 systemic systemic JJ cord-014516-r59usk02 720 11 PHF PHF NNP cord-014516-r59usk02 720 12 occurs occur VBZ cord-014516-r59usk02 720 13 also also RB cord-014516-r59usk02 720 14 in in IN cord-014516-r59usk02 720 15 dogs dog NNS cord-014516-r59usk02 720 16 with with IN cord-014516-r59usk02 720 17 PE PE NNP cord-014516-r59usk02 720 18 . . . cord-014516-r59usk02 721 1 Thirty thirty CD cord-014516-r59usk02 721 2 - - HYPH cord-014516-r59usk02 721 3 three three CD cord-014516-r59usk02 721 4 dogs dog NNS cord-014516-r59usk02 721 5 referred refer VBD cord-014516-r59usk02 721 6 to to IN cord-014516-r59usk02 721 7 the the DT cord-014516-r59usk02 721 8 San San NNP cord-014516-r59usk02 721 9 Marco Marco NNP cord-014516-r59usk02 721 10 Veterinary Veterinary NNP cord-014516-r59usk02 721 11 Clinic Clinic NNP cord-014516-r59usk02 721 12 with with IN cord-014516-r59usk02 721 13 PE PE NNP cord-014516-r59usk02 721 14 , , , cord-014516-r59usk02 721 15 but but CC cord-014516-r59usk02 721 16 without without IN cord-014516-r59usk02 721 17 ascites ascites NN cord-014516-r59usk02 721 18 , , , cord-014516-r59usk02 721 19 were be VBD cord-014516-r59usk02 721 20 studied study VBN cord-014516-r59usk02 721 21 ( ( -LRB- cord-014516-r59usk02 721 22 group group NN cord-014516-r59usk02 721 23 1 1 CD cord-014516-r59usk02 721 24 ) ) -RRB- cord-014516-r59usk02 721 25 . . . cord-014516-r59usk02 722 1 From from IN cord-014516-r59usk02 722 2 the the DT cord-014516-r59usk02 722 3 electronic electronic JJ cord-014516-r59usk02 722 4 data data NN cord-014516-r59usk02 722 5 - - HYPH cord-014516-r59usk02 722 6 base base NN cord-014516-r59usk02 722 7 of of IN cord-014516-r59usk02 722 8 the the DT cord-014516-r59usk02 722 9 clinic clinic NN cord-014516-r59usk02 722 10 dogs dog NNS cord-014516-r59usk02 722 11 for for IN cord-014516-r59usk02 722 12 inclusion inclusion NN cord-014516-r59usk02 722 13 in in IN cord-014516-r59usk02 722 14 control control NN cord-014516-r59usk02 722 15 groups group NNS cord-014516-r59usk02 722 16 2 2 LS cord-014516-r59usk02 722 17 ( ( -LRB- cord-014516-r59usk02 722 18 healthy healthy JJ cord-014516-r59usk02 722 19 dogs dog NNS cord-014516-r59usk02 722 20 ) ) -RRB- cord-014516-r59usk02 722 21 and and CC cord-014516-r59usk02 722 22 3 3 LS cord-014516-r59usk02 722 23 ( ( -LRB- cord-014516-r59usk02 722 24 sick sick JJ cord-014516-r59usk02 722 25 dogs dog NNS cord-014516-r59usk02 722 26 without without IN cord-014516-r59usk02 722 27 PE PE NNP cord-014516-r59usk02 722 28 or or CC cord-014516-r59usk02 722 29 ascites ascite NNS cord-014516-r59usk02 722 30 ) ) -RRB- cord-014516-r59usk02 722 31 were be VBD cord-014516-r59usk02 722 32 randomly randomly RB cord-014516-r59usk02 722 33 selected select VBN cord-014516-r59usk02 722 34 and and CC cord-014516-r59usk02 722 35 individually individually RB cord-014516-r59usk02 722 36 matched match VBN cord-014516-r59usk02 722 37 to to IN cord-014516-r59usk02 722 38 group group NN cord-014516-r59usk02 722 39 1 1 CD cord-014516-r59usk02 722 40 dogs dog NNS cord-014516-r59usk02 722 41 for for IN cord-014516-r59usk02 722 42 age age NN cord-014516-r59usk02 722 43 , , , cord-014516-r59usk02 722 44 sex sex NN cord-014516-r59usk02 722 45 , , , cord-014516-r59usk02 722 46 and and CC cord-014516-r59usk02 722 47 breed breed VB cord-014516-r59usk02 722 48 . . . cord-014516-r59usk02 723 1 Fibrinogen fibrinogen NN cord-014516-r59usk02 723 2 , , , cord-014516-r59usk02 723 3 FDPs fdp NNS cord-014516-r59usk02 723 4 , , , cord-014516-r59usk02 723 5 D d NN cord-014516-r59usk02 723 6 - - HYPH cord-014516-r59usk02 723 7 dimers dimer NNS cord-014516-r59usk02 723 8 , , , cord-014516-r59usk02 723 9 C c NN cord-014516-r59usk02 723 10 - - HYPH cord-014516-r59usk02 723 11 reactive reactive JJ cord-014516-r59usk02 723 12 protein protein NN cord-014516-r59usk02 723 13 ( ( -LRB- cord-014516-r59usk02 723 14 CRP CRP NNP cord-014516-r59usk02 723 15 ) ) -RRB- cord-014516-r59usk02 723 16 , , , cord-014516-r59usk02 723 17 fibrinogen fibrinogen NN cord-014516-r59usk02 723 18 / / SYM cord-014516-r59usk02 723 19 CRP crp NN cord-014516-r59usk02 723 20 ratio ratio NN cord-014516-r59usk02 723 21 , , , cord-014516-r59usk02 723 22 and and CC cord-014516-r59usk02 723 23 prevalence prevalence NN cord-014516-r59usk02 723 24 of of IN cord-014516-r59usk02 723 25 PHF PHF NNP cord-014516-r59usk02 723 26 ( ( -LRB- cord-014516-r59usk02 723 27 i.e. i.e. FW cord-014516-r59usk02 723 28 , , , cord-014516-r59usk02 723 29 dogs dog NNS cord-014516-r59usk02 723 30 with with IN cord-014516-r59usk02 723 31 elevated elevated JJ cord-014516-r59usk02 723 32 plasma plasma NN cord-014516-r59usk02 723 33 FDPs fdp NNS cord-014516-r59usk02 723 34 and and CC cord-014516-r59usk02 723 35 normal normal JJ cord-014516-r59usk02 723 36 D d NN cord-014516-r59usk02 723 37 - - HYPH cord-014516-r59usk02 723 38 dimer dimer NN cord-014516-r59usk02 723 39 ) ) -RRB- cord-014516-r59usk02 723 40 were be VBD cord-014516-r59usk02 723 41 determined determine VBN cord-014516-r59usk02 723 42 . . . cord-014516-r59usk02 724 1 Differences difference NNS cord-014516-r59usk02 724 2 between between IN cord-014516-r59usk02 724 3 the the DT cord-014516-r59usk02 724 4 3 3 CD cord-014516-r59usk02 724 5 groups group NNS cord-014516-r59usk02 724 6 were be VBD cord-014516-r59usk02 724 7 analyzed analyze VBN cord-014516-r59usk02 724 8 using use VBG cord-014516-r59usk02 724 9 ANOVA ANOVA NNP cord-014516-r59usk02 724 10 ( ( -LRB- cord-014516-r59usk02 724 11 fibrinogen fibrinogen NN cord-014516-r59usk02 724 12 ) ) -RRB- cord-014516-r59usk02 724 13 , , , cord-014516-r59usk02 724 14 Chi Chi NNP cord-014516-r59usk02 724 15 - - HYPH cord-014516-r59usk02 724 16 Square Square NNP cord-014516-r59usk02 724 17 ( ( -LRB- cord-014516-r59usk02 724 18 FDPs fdp NNS cord-014516-r59usk02 724 19 and and CC cord-014516-r59usk02 724 20 prevalence prevalence NN cord-014516-r59usk02 724 21 of of IN cord-014516-r59usk02 724 22 PHF PHF NNP cord-014516-r59usk02 724 23 ) ) -RRB- cord-014516-r59usk02 724 24 and and CC cord-014516-r59usk02 724 25 Kruskal Kruskal NNP cord-014516-r59usk02 724 26 - - HYPH cord-014516-r59usk02 724 27 Wallis Wallis NNP cord-014516-r59usk02 724 28 test test NN cord-014516-r59usk02 724 29 ( ( -LRB- cord-014516-r59usk02 724 30 CRP CRP NNP cord-014516-r59usk02 724 31 , , , cord-014516-r59usk02 724 32 fibrinogen fibrinogen NN cord-014516-r59usk02 724 33 / / SYM cord-014516-r59usk02 724 34 CRP crp NN cord-014516-r59usk02 724 35 ratio ratio NN cord-014516-r59usk02 724 36 , , , cord-014516-r59usk02 724 37 and and CC cord-014516-r59usk02 724 38 D d NN cord-014516-r59usk02 724 39 - - HYPH cord-014516-r59usk02 724 40 dimer dimer NN cord-014516-r59usk02 724 41 ) ) -RRB- cord-014516-r59usk02 724 42 . . . cord-014516-r59usk02 725 1 Post post JJ cord-014516-r59usk02 725 2 - - JJ cord-014516-r59usk02 725 3 test test JJ cord-014516-r59usk02 725 4 analysis analysis NN cord-014516-r59usk02 725 5 were be VBD cord-014516-r59usk02 725 6 performed perform VBN cord-014516-r59usk02 725 7 by by IN cord-014516-r59usk02 725 8 Tamhane Tamhane NNP cord-014516-r59usk02 725 9 and and CC cord-014516-r59usk02 725 10 Mann Mann NNP cord-014516-r59usk02 725 11 - - HYPH cord-014516-r59usk02 725 12 Whitney Whitney NNP cord-014516-r59usk02 725 13 test test NN cord-014516-r59usk02 725 14 . . . cord-014516-r59usk02 726 1 Fibrinogen fibrinogen NN cord-014516-r59usk02 726 2 concentration concentration NN cord-014516-r59usk02 726 3 in in IN cord-014516-r59usk02 726 4 group group NN cord-014516-r59usk02 726 5 1 1 CD cord-014516-r59usk02 726 6 was be VBD cord-014516-r59usk02 726 7 significantly significantly RB cord-014516-r59usk02 726 8 increased increase VBN cord-014516-r59usk02 726 9 compared compare VBN cord-014516-r59usk02 726 10 to to IN cord-014516-r59usk02 726 11 group group NN cord-014516-r59usk02 726 12 2 2 CD cord-014516-r59usk02 726 13 ( ( -LRB- cord-014516-r59usk02 726 14 p p NN cord-014516-r59usk02 726 15 < < XX cord-014516-r59usk02 726 16 0.0001 0.0001 CD cord-014516-r59usk02 726 17 ) ) -RRB- cord-014516-r59usk02 726 18 , , , cord-014516-r59usk02 726 19 but but CC cord-014516-r59usk02 726 20 not not RB cord-014516-r59usk02 726 21 compared compare VBN cord-014516-r59usk02 726 22 to to IN cord-014516-r59usk02 726 23 group group NN cord-014516-r59usk02 726 24 3 3 CD cord-014516-r59usk02 726 25 ( ( -LRB- cord-014516-r59usk02 726 26 p p NN cord-014516-r59usk02 726 27 = = SYM cord-014516-r59usk02 726 28 0.504 0.504 CD cord-014516-r59usk02 726 29 ) ) -RRB- cord-014516-r59usk02 726 30 . . . cord-014516-r59usk02 727 1 FDPs FDPs NNP cord-014516-r59usk02 727 2 concentration concentration NN cord-014516-r59usk02 727 3 in in IN cord-014516-r59usk02 727 4 group group NN cord-014516-r59usk02 727 5 1 1 CD cord-014516-r59usk02 727 6 was be VBD cord-014516-r59usk02 727 7 significantly significantly RB cord-014516-r59usk02 727 8 increased increase VBN cord-014516-r59usk02 727 9 compared compare VBN cord-014516-r59usk02 727 10 to to IN cord-014516-r59usk02 727 11 groups group NNS cord-014516-r59usk02 727 12 2 2 CD cord-014516-r59usk02 727 13 ( ( -LRB- cord-014516-r59usk02 727 14 p p NN cord-014516-r59usk02 727 15 < < XX cord-014516-r59usk02 727 16 0.0001 0.0001 CD cord-014516-r59usk02 727 17 ) ) -RRB- cord-014516-r59usk02 727 18 , , , cord-014516-r59usk02 727 19 but but CC cord-014516-r59usk02 727 20 not not RB cord-014516-r59usk02 727 21 compared compare VBN cord-014516-r59usk02 727 22 to to IN cord-014516-r59usk02 727 23 group group NN cord-014516-r59usk02 727 24 3 3 CD cord-014516-r59usk02 727 25 ( ( -LRB- cord-014516-r59usk02 727 26 p p NN cord-014516-r59usk02 727 27 = = SYM cord-014516-r59usk02 727 28 0.148 0.148 CD cord-014516-r59usk02 727 29 ) ) -RRB- cord-014516-r59usk02 727 30 . . . cord-014516-r59usk02 728 1 D D NNS cord-014516-r59usk02 728 2 - - HYPH cord-014516-r59usk02 728 3 dimers dimer NNS cord-014516-r59usk02 728 4 concentration concentration NN cord-014516-r59usk02 728 5 in in IN cord-014516-r59usk02 728 6 group group NN cord-014516-r59usk02 728 7 1 1 CD cord-014516-r59usk02 728 8 was be VBD cord-014516-r59usk02 728 9 significantly significantly RB cord-014516-r59usk02 728 10 increased increase VBN cord-014516-r59usk02 728 11 compared compare VBN cord-014516-r59usk02 728 12 to to IN cord-014516-r59usk02 728 13 group group NN cord-014516-r59usk02 728 14 2 2 CD cord-014516-r59usk02 728 15 ( ( -LRB- cord-014516-r59usk02 728 16 p p NN cord-014516-r59usk02 728 17 < < XX cord-014516-r59usk02 728 18 0.0001 0.0001 CD cord-014516-r59usk02 728 19 ) ) -RRB- cord-014516-r59usk02 728 20 , , , cord-014516-r59usk02 728 21 but but CC cord-014516-r59usk02 728 22 not not RB cord-014516-r59usk02 728 23 compared compare VBN cord-014516-r59usk02 728 24 to to IN cord-014516-r59usk02 728 25 group group NN cord-014516-r59usk02 728 26 3 3 CD cord-014516-r59usk02 728 27 ( ( -LRB- cord-014516-r59usk02 728 28 p p NN cord-014516-r59usk02 728 29 = = SYM cord-014516-r59usk02 728 30 0.964 0.964 CD cord-014516-r59usk02 728 31 ) ) -RRB- cord-014516-r59usk02 728 32 . . . cord-014516-r59usk02 729 1 CRP CRP NNP cord-014516-r59usk02 729 2 was be VBD cord-014516-r59usk02 729 3 significantly significantly RB cord-014516-r59usk02 729 4 increased increase VBN cord-014516-r59usk02 729 5 in in IN cord-014516-r59usk02 729 6 group group NN cord-014516-r59usk02 729 7 1 1 CD cord-014516-r59usk02 729 8 compared compare VBN cord-014516-r59usk02 729 9 to to IN cord-014516-r59usk02 729 10 group group NN cord-014516-r59usk02 729 11 2 2 CD cord-014516-r59usk02 729 12 and and CC cord-014516-r59usk02 729 13 3 3 CD cord-014516-r59usk02 730 1 ( ( -LRB- cord-014516-r59usk02 730 2 p p NN cord-014516-r59usk02 730 3 < < XX cord-014516-r59usk02 730 4 0.0001 0.0001 CD cord-014516-r59usk02 730 5 for for IN cord-014516-r59usk02 730 6 both both DT cord-014516-r59usk02 730 7 comparison comparison NN cord-014516-r59usk02 730 8 ) ) -RRB- cord-014516-r59usk02 730 9 . . . cord-014516-r59usk02 731 1 Fibrinogen Fibrinogen NNP cord-014516-r59usk02 731 2 / / SYM cord-014516-r59usk02 731 3 CRP crp NN cord-014516-r59usk02 731 4 ratio ratio NN cord-014516-r59usk02 731 5 was be VBD cord-014516-r59usk02 731 6 significantly significantly RB cord-014516-r59usk02 731 7 decreased decrease VBN cord-014516-r59usk02 731 8 in in IN cord-014516-r59usk02 731 9 group group NN cord-014516-r59usk02 731 10 1 1 CD cord-014516-r59usk02 731 11 compared compare VBN cord-014516-r59usk02 731 12 to to IN cord-014516-r59usk02 731 13 group group NN cord-014516-r59usk02 731 14 2 2 CD cord-014516-r59usk02 731 15 and and CC cord-014516-r59usk02 731 16 3 3 CD cord-014516-r59usk02 732 1 ( ( -LRB- cord-014516-r59usk02 732 2 p p NN cord-014516-r59usk02 732 3 < < XX cord-014516-r59usk02 732 4 0.0001 0.0001 CD cord-014516-r59usk02 732 5 for for IN cord-014516-r59usk02 732 6 both both DT cord-014516-r59usk02 732 7 comparison comparison NN cord-014516-r59usk02 732 8 ) ) -RRB- cord-014516-r59usk02 732 9 . . . cord-014516-r59usk02 733 1 Prevalence prevalence NN cord-014516-r59usk02 733 2 of of IN cord-014516-r59usk02 733 3 PHF PHF NNP cord-014516-r59usk02 733 4 was be VBD cord-014516-r59usk02 733 5 significantly significantly RB cord-014516-r59usk02 733 6 higher high JJR cord-014516-r59usk02 733 7 in in IN cord-014516-r59usk02 733 8 group group NN cord-014516-r59usk02 733 9 1 1 CD cord-014516-r59usk02 733 10 compared compare VBN cord-014516-r59usk02 733 11 to to IN cord-014516-r59usk02 733 12 groups group NNS cord-014516-r59usk02 733 13 2 2 CD cord-014516-r59usk02 733 14 ( ( -LRB- cord-014516-r59usk02 733 15 p p NN cord-014516-r59usk02 733 16 = = SYM cord-014516-r59usk02 733 17 0.004 0.004 CD cord-014516-r59usk02 733 18 ) ) -RRB- cord-014516-r59usk02 733 19 , , , cord-014516-r59usk02 733 20 but but CC cord-014516-r59usk02 733 21 not not RB cord-014516-r59usk02 733 22 compared compare VBN cord-014516-r59usk02 733 23 to to IN cord-014516-r59usk02 733 24 group group NN cord-014516-r59usk02 733 25 3 3 CD cord-014516-r59usk02 733 26 ( ( -LRB- cord-014516-r59usk02 733 27 p p NN cord-014516-r59usk02 733 28 = = SYM cord-014516-r59usk02 733 29 0.186 0.186 CD cord-014516-r59usk02 733 30 ) ) -RRB- cord-014516-r59usk02 733 31 . . . cord-014516-r59usk02 734 1 These these DT cord-014516-r59usk02 734 2 results result NNS cord-014516-r59usk02 734 3 support support VBP cord-014516-r59usk02 734 4 the the DT cord-014516-r59usk02 734 5 hypothesis hypothesis NN cord-014516-r59usk02 734 6 that that IN cord-014516-r59usk02 734 7 PHF PHF NNP cord-014516-r59usk02 734 8 occurs occur VBZ cord-014516-r59usk02 734 9 significantly significantly RB cord-014516-r59usk02 734 10 more more RBR cord-014516-r59usk02 734 11 often often RB cord-014516-r59usk02 734 12 in in IN cord-014516-r59usk02 734 13 dogs dog NNS cord-014516-r59usk02 734 14 with with IN cord-014516-r59usk02 734 15 PE pe NN cord-014516-r59usk02 734 16 compared compare VBN cord-014516-r59usk02 734 17 to to IN cord-014516-r59usk02 734 18 healthy healthy JJ cord-014516-r59usk02 734 19 dogs dog NNS cord-014516-r59usk02 734 20 . . . cord-014516-r59usk02 735 1 Despite despite IN cord-014516-r59usk02 735 2 there there EX cord-014516-r59usk02 735 3 was be VBD cord-014516-r59usk02 735 4 a a DT cord-014516-r59usk02 735 5 trend trend NN cord-014516-r59usk02 735 6 of of IN cord-014516-r59usk02 735 7 increased increase VBN cord-014516-r59usk02 735 8 PHF PHF NNP cord-014516-r59usk02 735 9 also also RB cord-014516-r59usk02 735 10 in in IN cord-014516-r59usk02 735 11 dogs dog NNS cord-014516-r59usk02 735 12 with with IN cord-014516-r59usk02 735 13 PE pe NN cord-014516-r59usk02 735 14 compared compare VBN cord-014516-r59usk02 735 15 to to IN cord-014516-r59usk02 735 16 sick sick JJ cord-014516-r59usk02 735 17 dogs dog NNS cord-014516-r59usk02 735 18 , , , cord-014516-r59usk02 735 19 this this DT cord-014516-r59usk02 735 20 difference difference NN cord-014516-r59usk02 735 21 did do VBD cord-014516-r59usk02 735 22 not not RB cord-014516-r59usk02 735 23 reach reach VB cord-014516-r59usk02 735 24 significance significance NN cord-014516-r59usk02 735 25 . . . cord-014516-r59usk02 736 1 Nevertheless nevertheless RB cord-014516-r59usk02 736 2 , , , cord-014516-r59usk02 736 3 the the DT cord-014516-r59usk02 736 4 decreased decrease VBD cord-014516-r59usk02 736 5 in in IN cord-014516-r59usk02 736 6 fibrinogen fibrinogen NN cord-014516-r59usk02 736 7 / / SYM cord-014516-r59usk02 736 8 CRP crp NN cord-014516-r59usk02 736 9 ratio ratio NN cord-014516-r59usk02 736 10 in in IN cord-014516-r59usk02 736 11 group group NN cord-014516-r59usk02 736 12 1 1 CD cord-014516-r59usk02 736 13 compared compare VBN cord-014516-r59usk02 736 14 to to IN cord-014516-r59usk02 736 15 group group NN cord-014516-r59usk02 736 16 3 3 CD cord-014516-r59usk02 736 17 , , , cord-014516-r59usk02 736 18 in in IN cord-014516-r59usk02 736 19 the the DT cord-014516-r59usk02 736 20 face face NN cord-014516-r59usk02 736 21 of of IN cord-014516-r59usk02 736 22 a a DT cord-014516-r59usk02 736 23 similar similar JJ cord-014516-r59usk02 736 24 D d NN cord-014516-r59usk02 736 25 - - HYPH cord-014516-r59usk02 736 26 dimer dimer NN cord-014516-r59usk02 736 27 concentration concentration NN cord-014516-r59usk02 736 28 , , , cord-014516-r59usk02 736 29 would would MD cord-014516-r59usk02 736 30 suggest suggest VB cord-014516-r59usk02 736 31 that that IN cord-014516-r59usk02 736 32 PHF PHF NNP cord-014516-r59usk02 736 33 is be VBZ cord-014516-r59usk02 736 34 also also RB cord-014516-r59usk02 736 35 more more RBR cord-014516-r59usk02 736 36 prevalent prevalent JJ cord-014516-r59usk02 736 37 in in IN cord-014516-r59usk02 736 38 dogs dog NNS cord-014516-r59usk02 736 39 with with IN cord-014516-r59usk02 736 40 PE pe NN cord-014516-r59usk02 736 41 compared compare VBN cord-014516-r59usk02 736 42 to to IN cord-014516-r59usk02 736 43 sick sick JJ cord-014516-r59usk02 736 44 control control NN cord-014516-r59usk02 736 45 dogs dog NNS cord-014516-r59usk02 736 46 . . . cord-014516-r59usk02 737 1 No no DT cord-014516-r59usk02 737 2 conflicts conflict NNS cord-014516-r59usk02 737 3 of of IN cord-014516-r59usk02 737 4 interest interest NN cord-014516-r59usk02 737 5 reported report VBN cord-014516-r59usk02 737 6 . . . cord-014516-r59usk02 738 1 The the DT cord-014516-r59usk02 738 2 systemic systemic JJ cord-014516-r59usk02 738 3 inflammatory inflammatory JJ cord-014516-r59usk02 738 4 response response NN cord-014516-r59usk02 738 5 syndrome syndrome NN cord-014516-r59usk02 738 6 ( ( -LRB- cord-014516-r59usk02 738 7 SIRS SIRS NNP cord-014516-r59usk02 738 8 ) ) -RRB- cord-014516-r59usk02 738 9 refers refer VBZ cord-014516-r59usk02 738 10 to to IN cord-014516-r59usk02 738 11 clinical clinical JJ cord-014516-r59usk02 738 12 signs sign NNS cord-014516-r59usk02 738 13 of of IN cord-014516-r59usk02 738 14 systemic systemic JJ cord-014516-r59usk02 738 15 inflammation inflammation NN cord-014516-r59usk02 738 16 in in IN cord-014516-r59usk02 738 17 response response NN cord-014516-r59usk02 738 18 to to IN cord-014516-r59usk02 738 19 ( ( -LRB- cord-014516-r59usk02 738 20 non- non- RB cord-014516-r59usk02 738 21 ) ) -RRB- cord-014516-r59usk02 738 22 infectious infectious JJ cord-014516-r59usk02 738 23 insults insult NNS cord-014516-r59usk02 738 24 . . . cord-014516-r59usk02 739 1 Current current JJ cord-014516-r59usk02 739 2 diagnosis diagnosis NN cord-014516-r59usk02 739 3 of of IN cord-014516-r59usk02 739 4 SIRS SIRS NNP cord-014516-r59usk02 739 5 is be VBZ cord-014516-r59usk02 739 6 based base VBN cord-014516-r59usk02 739 7 on on IN cord-014516-r59usk02 739 8 clinical clinical JJ cord-014516-r59usk02 739 9 and and CC cord-014516-r59usk02 739 10 basic basic JJ cord-014516-r59usk02 739 11 laboratory laboratory NN cord-014516-r59usk02 739 12 data datum NNS cord-014516-r59usk02 739 13 and and CC cord-014516-r59usk02 739 14 is be VBZ cord-014516-r59usk02 739 15 a a DT cord-014516-r59usk02 739 16 sensitive sensitive JJ cord-014516-r59usk02 739 17 screening screening NN cord-014516-r59usk02 739 18 to to TO cord-014516-r59usk02 739 19 identify identify VB cord-014516-r59usk02 739 20 patients patient NNS cord-014516-r59usk02 739 21 at at IN cord-014516-r59usk02 739 22 risk risk NN cord-014516-r59usk02 739 23 . . . cord-014516-r59usk02 740 1 C C NNP cord-014516-r59usk02 740 2 - - HYPH cord-014516-r59usk02 740 3 reactive reactive JJ cord-014516-r59usk02 740 4 protein protein NN cord-014516-r59usk02 740 5 ( ( -LRB- cord-014516-r59usk02 740 6 CRP CRP NNP cord-014516-r59usk02 740 7 ) ) -RRB- cord-014516-r59usk02 740 8 is be VBZ cord-014516-r59usk02 740 9 a a DT cord-014516-r59usk02 740 10 major major JJ cord-014516-r59usk02 740 11 canine canine JJ cord-014516-r59usk02 740 12 acute acute JJ cord-014516-r59usk02 740 13 phase phase NN cord-014516-r59usk02 740 14 protein protein NN cord-014516-r59usk02 740 15 with with IN cord-014516-r59usk02 740 16 concentrations concentration NNS cord-014516-r59usk02 740 17 related relate VBN cord-014516-r59usk02 740 18 to to IN cord-014516-r59usk02 740 19 disease disease NN cord-014516-r59usk02 740 20 severity severity NN cord-014516-r59usk02 740 21 and and CC cord-014516-r59usk02 740 22 underlying underlying JJ cord-014516-r59usk02 740 23 cause cause NN cord-014516-r59usk02 740 24 . . . cord-014516-r59usk02 741 1 CRP CRP NNP cord-014516-r59usk02 741 2 rises rise VBZ cord-014516-r59usk02 741 3 in in IN cord-014516-r59usk02 741 4 response response NN cord-014516-r59usk02 741 5 to to IN cord-014516-r59usk02 741 6 proinflammatory proinflammatory JJ cord-014516-r59usk02 741 7 cytokines cytokine NNS cord-014516-r59usk02 741 8 , , , cord-014516-r59usk02 741 9 mainly mainly RB cord-014516-r59usk02 741 10 interleukin interleukin JJ cord-014516-r59usk02 741 11 ( ( -LRB- cord-014516-r59usk02 741 12 IL)-6 il)-6 NN cord-014516-r59usk02 741 13 and and CC cord-014516-r59usk02 741 14 tumor tumor NN cord-014516-r59usk02 741 15 necrosis necrosis NN cord-014516-r59usk02 741 16 factor factor NN cord-014516-r59usk02 741 17 ( ( -LRB- cord-014516-r59usk02 741 18 TNF)-a TNF)-a NNP cord-014516-r59usk02 741 19 , , , cord-014516-r59usk02 741 20 which which WDT cord-014516-r59usk02 741 21 are be VBP cord-014516-r59usk02 741 22 considered consider VBN cord-014516-r59usk02 741 23 the the DT cord-014516-r59usk02 741 24 main main JJ cord-014516-r59usk02 741 25 triggers trigger NNS cord-014516-r59usk02 741 26 of of IN cord-014516-r59usk02 741 27 SIRS SIRS NNP cord-014516-r59usk02 741 28 . . . cord-014516-r59usk02 742 1 We -PRON- PRP cord-014516-r59usk02 742 2 therefore therefore RB cord-014516-r59usk02 742 3 evaluated evaluate VBD cord-014516-r59usk02 742 4 CRP CRP NNP cord-014516-r59usk02 742 5 , , , cord-014516-r59usk02 742 6 IL-6 IL-6 NNP cord-014516-r59usk02 742 7 and and CC cord-014516-r59usk02 742 8 TNF TNF NNP cord-014516-r59usk02 742 9 - - : cord-014516-r59usk02 742 10 a a DT cord-014516-r59usk02 742 11 kinetics kinetics NN cord-014516-r59usk02 742 12 in in IN cord-014516-r59usk02 742 13 canine canine JJ cord-014516-r59usk02 742 14 emergency emergency NN cord-014516-r59usk02 742 15 SIRS SIRS NNP cord-014516-r59usk02 742 16 patients patient NNS cord-014516-r59usk02 742 17 hypothesizing hypothesize VBG cord-014516-r59usk02 742 18 that that IN cord-014516-r59usk02 742 19 CRP CRP NNP cord-014516-r59usk02 742 20 is be VBZ cord-014516-r59usk02 742 21 ( ( -LRB- cord-014516-r59usk02 742 22 1 1 CD cord-014516-r59usk02 742 23 ) ) -RRB- cord-014516-r59usk02 742 24 increased increase VBD cord-014516-r59usk02 742 25 in in IN cord-014516-r59usk02 742 26 dogs dog NNS cord-014516-r59usk02 742 27 with with IN cord-014516-r59usk02 742 28 a a DT cord-014516-r59usk02 742 29 clinical clinical JJ cord-014516-r59usk02 742 30 SIRS sirs NN cord-014516-r59usk02 742 31 - - HYPH cord-014516-r59usk02 742 32 diagnosis diagnosis NN cord-014516-r59usk02 742 33 , , , cord-014516-r59usk02 742 34 ( ( -LRB- cord-014516-r59usk02 742 35 2 2 LS cord-014516-r59usk02 742 36 ) ) -RRB- cord-014516-r59usk02 742 37 correlated correlate VBN cord-014516-r59usk02 742 38 with with IN cord-014516-r59usk02 742 39 IL-6 IL-6 NNP cord-014516-r59usk02 742 40 and and CC cord-014516-r59usk02 742 41 TNF TNF NNP cord-014516-r59usk02 742 42 - - : cord-014516-r59usk02 742 43 a a DT cord-014516-r59usk02 742 44 concentrations concentration NNS cord-014516-r59usk02 742 45 , , , cord-014516-r59usk02 742 46 ( ( -LRB- cord-014516-r59usk02 742 47 3 3 LS cord-014516-r59usk02 742 48 ) ) -RRB- cord-014516-r59usk02 742 49 influenced influence VBN cord-014516-r59usk02 742 50 by by IN cord-014516-r59usk02 742 51 the the DT cord-014516-r59usk02 742 52 underlying underlie VBG cord-014516-r59usk02 742 53 etiology etiology NN cord-014516-r59usk02 742 54 , , , cord-014516-r59usk02 742 55 and and CC cord-014516-r59usk02 742 56 ( ( -LRB- cord-014516-r59usk02 742 57 4 4 LS cord-014516-r59usk02 742 58 ) ) -RRB- cord-014516-r59usk02 742 59 a a DT cord-014516-r59usk02 742 60 prognostic prognostic JJ cord-014516-r59usk02 742 61 marker marker NN cord-014516-r59usk02 742 62 . . . cord-014516-r59usk02 743 1 Canine canine JJ cord-014516-r59usk02 743 2 emergencies emergency NNS cord-014516-r59usk02 743 3 with with IN cord-014516-r59usk02 743 4 clinically clinically RB cord-014516-r59usk02 743 5 diagnosed diagnose VBN cord-014516-r59usk02 743 6 SIRS sir NNS cord-014516-r59usk02 743 7 were be VBD cord-014516-r59usk02 743 8 prospectively prospectively RB cord-014516-r59usk02 743 9 included include VBN cord-014516-r59usk02 743 10 . . . cord-014516-r59usk02 744 1 Serum serum NN cord-014516-r59usk02 744 2 and and CC cord-014516-r59usk02 744 3 plasma plasma NN cord-014516-r59usk02 744 4 were be VBD cord-014516-r59usk02 744 5 immediately immediately RB cord-014516-r59usk02 744 6 stored store VBN cord-014516-r59usk02 744 7 at at IN cord-014516-r59usk02 744 8 -80 -80 NNP cord-014516-r59usk02 744 9 ° ° NN cord-014516-r59usk02 744 10 C C NNP cord-014516-r59usk02 744 11 after after IN cord-014516-r59usk02 744 12 sampling sampling NN cord-014516-r59usk02 744 13 at at IN cord-014516-r59usk02 744 14 presentation presentation NN cord-014516-r59usk02 744 15 , , , cord-014516-r59usk02 744 16 after after IN cord-014516-r59usk02 744 17 6 6 CD cord-014516-r59usk02 744 18 ( ( -LRB- cord-014516-r59usk02 744 19 T6 T6 NNP cord-014516-r59usk02 744 20 ) ) -RRB- cord-014516-r59usk02 744 21 , , , cord-014516-r59usk02 744 22 12 12 CD cord-014516-r59usk02 744 23 ( ( -LRB- cord-014516-r59usk02 744 24 T12 T12 NNP cord-014516-r59usk02 744 25 ) ) -RRB- cord-014516-r59usk02 744 26 , , , cord-014516-r59usk02 744 27 24 24 CD cord-014516-r59usk02 744 28 ( ( -LRB- cord-014516-r59usk02 744 29 T24 T24 NNP cord-014516-r59usk02 744 30 ) ) -RRB- cord-014516-r59usk02 744 31 and and CC cord-014516-r59usk02 744 32 72 72 CD cord-014516-r59usk02 744 33 ( ( -LRB- cord-014516-r59usk02 744 34 T72 T72 NNP cord-014516-r59usk02 744 35 ) ) -RRB- cord-014516-r59usk02 744 36 hours hour NNS cord-014516-r59usk02 744 37 , , , cord-014516-r59usk02 744 38 and and CC cord-014516-r59usk02 744 39 at at IN cord-014516-r59usk02 744 40 a a DT cord-014516-r59usk02 744 41 control control NN cord-014516-r59usk02 744 42 visit visit NN cord-014516-r59usk02 744 43 ( ( -LRB- cord-014516-r59usk02 744 44 T1 T1 NNP cord-014516-r59usk02 744 45 m m NNP cord-014516-r59usk02 744 46 ) ) -RRB- cord-014516-r59usk02 744 47 over over IN cord-014516-r59usk02 744 48 one one CD cord-014516-r59usk02 744 49 month month NN cord-014516-r59usk02 744 50 after after IN cord-014516-r59usk02 744 51 discharge discharge NN cord-014516-r59usk02 744 52 . . . cord-014516-r59usk02 745 1 Serum serum NN cord-014516-r59usk02 745 2 CRP CRP NNP cord-014516-r59usk02 745 3 was be VBD cord-014516-r59usk02 745 4 measured measure VBN cord-014516-r59usk02 745 5 with with IN cord-014516-r59usk02 745 6 a a DT cord-014516-r59usk02 745 7 caninespecific caninespecific NNP cord-014516-r59usk02 745 8 immunoturbidimetric immunoturbidimetric NNP cord-014516-r59usk02 745 9 CRP CRP NNP cord-014516-r59usk02 745 10 assay assay NN cord-014516-r59usk02 745 11 . . . cord-014516-r59usk02 746 1 Plasma Plasma NNP cord-014516-r59usk02 746 2 IL-6 IL-6 NNP cord-014516-r59usk02 746 3 and and CC cord-014516-r59usk02 746 4 TNFa TNFa NNP cord-014516-r59usk02 746 5 were be VBD cord-014516-r59usk02 746 6 measured measure VBN cord-014516-r59usk02 746 7 using use VBG cord-014516-r59usk02 746 8 a a DT cord-014516-r59usk02 746 9 bioassay bioassay NN cord-014516-r59usk02 746 10 measuring measure VBG cord-014516-r59usk02 746 11 biologically biologically RB cord-014516-r59usk02 746 12 active active JJ cord-014516-r59usk02 746 13 cytokine cytokine NN cord-014516-r59usk02 746 14 concentrations concentration NNS cord-014516-r59usk02 746 15 . . . cord-014516-r59usk02 747 1 Disease disease NN cord-014516-r59usk02 747 2 categories category NNS cord-014516-r59usk02 747 3 were be VBD cord-014516-r59usk02 747 4 infection infection NN cord-014516-r59usk02 747 5 ( ( -LRB- cord-014516-r59usk02 747 6 I i NN cord-014516-r59usk02 747 7 ) ) -RRB- cord-014516-r59usk02 747 8 , , , cord-014516-r59usk02 747 9 neoplasia neoplasia FW cord-014516-r59usk02 747 10 ( ( -LRB- cord-014516-r59usk02 747 11 N N NNP cord-014516-r59usk02 747 12 ) ) -RRB- cord-014516-r59usk02 747 13 , , , cord-014516-r59usk02 747 14 trauma trauma NN cord-014516-r59usk02 747 15 ( ( -LRB- cord-014516-r59usk02 747 16 T T NNP cord-014516-r59usk02 747 17 ) ) -RRB- cord-014516-r59usk02 747 18 , , , cord-014516-r59usk02 747 19 gastric gastric JJ cord-014516-r59usk02 747 20 - - HYPH cord-014516-r59usk02 747 21 dilation dilation NN cord-014516-r59usk02 747 22 and and CC cord-014516-r59usk02 747 23 volvulus volvulus NN cord-014516-r59usk02 747 24 ( ( -LRB- cord-014516-r59usk02 747 25 GDV GDV NNP cord-014516-r59usk02 747 26 ) ) -RRB- cord-014516-r59usk02 747 27 , , , cord-014516-r59usk02 747 28 other other JJ cord-014516-r59usk02 747 29 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 747 30 ( ( -LRB- cord-014516-r59usk02 747 31 GI GI NNP cord-014516-r59usk02 747 32 ) ) -RRB- cord-014516-r59usk02 747 33 , , , cord-014516-r59usk02 747 34 renal renal JJ cord-014516-r59usk02 747 35 ( ( -LRB- cord-014516-r59usk02 747 36 R r NN cord-014516-r59usk02 747 37 ) ) -RRB- cord-014516-r59usk02 747 38 and and CC cord-014516-r59usk02 747 39 miscellaneous miscellaneous JJ cord-014516-r59usk02 747 40 ( ( -LRB- cord-014516-r59usk02 747 41 M M NNP cord-014516-r59usk02 747 42 ) ) -RRB- cord-014516-r59usk02 747 43 diseases disease NNS cord-014516-r59usk02 747 44 . . . cord-014516-r59usk02 748 1 Statistical statistical JJ cord-014516-r59usk02 748 2 analysis analysis NN cord-014516-r59usk02 748 3 was be VBD cord-014516-r59usk02 748 4 performed perform VBN cord-014516-r59usk02 748 5 with with IN cord-014516-r59usk02 748 6 SAS SAS NNP cord-014516-r59usk02 748 7 . . . cord-014516-r59usk02 749 1 Concentrations concentration NNS cord-014516-r59usk02 749 2 of of IN cord-014516-r59usk02 749 3 inflammatory inflammatory JJ cord-014516-r59usk02 749 4 cytokines cytokine NNS cord-014516-r59usk02 749 5 were be VBD cord-014516-r59usk02 749 6 expressed express VBN cord-014516-r59usk02 749 7 logarithmically logarithmically RB cord-014516-r59usk02 749 8 , , , cord-014516-r59usk02 749 9 with with IN cord-014516-r59usk02 749 10 univariate univariate JJ cord-014516-r59usk02 749 11 analysis analysis NN cord-014516-r59usk02 749 12 confirming confirm VBG cord-014516-r59usk02 749 13 normal normal JJ cord-014516-r59usk02 749 14 distribution distribution NN cord-014516-r59usk02 749 15 . . . cord-014516-r59usk02 750 1 A a DT cord-014516-r59usk02 750 2 correlation correlation NN cord-014516-r59usk02 750 3 procedure procedure NN cord-014516-r59usk02 750 4 , , , cord-014516-r59usk02 750 5 mixed mixed JJ cord-014516-r59usk02 750 6 procedure procedure NN cord-014516-r59usk02 750 7 on on IN cord-014516-r59usk02 750 8 a a DT cord-014516-r59usk02 750 9 linear linear JJ cord-014516-r59usk02 750 10 model model NN cord-014516-r59usk02 750 11 and and CC cord-014516-r59usk02 750 12 a a DT cord-014516-r59usk02 750 13 logistic logistic JJ cord-014516-r59usk02 750 14 procedure procedure NN cord-014516-r59usk02 750 15 were be VBD cord-014516-r59usk02 750 16 performed perform VBN cord-014516-r59usk02 750 17 ( ( -LRB- cord-014516-r59usk02 750 18 p p NN cord-014516-r59usk02 750 19 - - HYPH cord-014516-r59usk02 750 20 value value NN cord-014516-r59usk02 750 21 < < XX cord-014516-r59usk02 750 22 0.05 0.05 CD cord-014516-r59usk02 750 23 ) ) -RRB- cord-014516-r59usk02 750 24 . . . cord-014516-r59usk02 751 1 Sixty sixty CD cord-014516-r59usk02 751 2 seven seven CD cord-014516-r59usk02 751 3 dogs dog NNS cord-014516-r59usk02 751 4 ( ( -LRB- cord-014516-r59usk02 751 5 I i NN cord-014516-r59usk02 751 6 = = SYM cord-014516-r59usk02 751 7 12 12 CD cord-014516-r59usk02 751 8 , , , cord-014516-r59usk02 751 9 N n CD cord-014516-r59usk02 751 10 = = SYM cord-014516-r59usk02 751 11 13 13 CD cord-014516-r59usk02 751 12 , , , cord-014516-r59usk02 751 13 T T NNP cord-014516-r59usk02 751 14 = = SYM cord-014516-r59usk02 751 15 6 6 CD cord-014516-r59usk02 751 16 , , , cord-014516-r59usk02 751 17 GDV=11 GDV=11 NNP cord-014516-r59usk02 751 18 , , , cord-014516-r59usk02 751 19 GI=4 GI=4 NNP cord-014516-r59usk02 751 20 , , , cord-014516-r59usk02 751 21 R r NN cord-014516-r59usk02 751 22 = = SYM cord-014516-r59usk02 751 23 3 3 CD cord-014516-r59usk02 751 24 , , , cord-014516-r59usk02 751 25 M M NNP cord-014516-r59usk02 751 26 = = SYM cord-014516-r59usk02 751 27 18 18 CD cord-014516-r59usk02 751 28 ) ) -RRB- cord-014516-r59usk02 751 29 were be VBD cord-014516-r59usk02 751 30 included include VBN cord-014516-r59usk02 751 31 . . . cord-014516-r59usk02 752 1 Forty forty CD cord-014516-r59usk02 752 2 - - HYPH cord-014516-r59usk02 752 3 three three CD cord-014516-r59usk02 752 4 patients patient NNS cord-014516-r59usk02 752 5 survived survive VBD cord-014516-r59usk02 752 6 ( ( -LRB- cord-014516-r59usk02 752 7 seven seven CD cord-014516-r59usk02 752 8 died die VBD cord-014516-r59usk02 752 9 , , , cord-014516-r59usk02 752 10 seventeen seventeen CD cord-014516-r59usk02 752 11 were be VBD cord-014516-r59usk02 752 12 euthanized euthanize VBN cord-014516-r59usk02 752 13 ) ) -RRB- cord-014516-r59usk02 752 14 . . . cord-014516-r59usk02 753 1 Twenty twenty CD cord-014516-r59usk02 753 2 patients patient NNS cord-014516-r59usk02 753 3 had have VBD cord-014516-r59usk02 753 4 a a DT cord-014516-r59usk02 753 5 control control NN cord-014516-r59usk02 753 6 visit visit NN cord-014516-r59usk02 753 7 . . . cord-014516-r59usk02 754 1 CRP CRP NNP cord-014516-r59usk02 754 2 was be VBD cord-014516-r59usk02 754 3 elevated elevate VBN cord-014516-r59usk02 754 4 in in IN cord-014516-r59usk02 754 5 71.2 71.2 CD cord-014516-r59usk02 754 6 % % NN cord-014516-r59usk02 754 7 of of IN cord-014516-r59usk02 754 8 dogs dog NNS cord-014516-r59usk02 754 9 at at IN cord-014516-r59usk02 754 10 presentation presentation NN cord-014516-r59usk02 754 11 , , , cord-014516-r59usk02 754 12 and and CC cord-014516-r59usk02 754 13 only only RB cord-014516-r59usk02 754 14 remained remain VBD cord-014516-r59usk02 754 15 within within IN cord-014516-r59usk02 754 16 reference reference NN cord-014516-r59usk02 754 17 range range NN cord-014516-r59usk02 754 18 ( ( -LRB- cord-014516-r59usk02 754 19 0 0 CD cord-014516-r59usk02 754 20 - - SYM cord-014516-r59usk02 754 21 14.9 14.9 CD cord-014516-r59usk02 754 22 mg mg NNP cord-014516-r59usk02 754 23 / / SYM cord-014516-r59usk02 754 24 L L NNP cord-014516-r59usk02 754 25 ) ) -RRB- cord-014516-r59usk02 754 26 throughout throughout IN cord-014516-r59usk02 754 27 hospitalization hospitalization NN cord-014516-r59usk02 754 28 in in IN cord-014516-r59usk02 754 29 four four CD cord-014516-r59usk02 754 30 dogs dog NNS cord-014516-r59usk02 754 31 ( ( -LRB- cord-014516-r59usk02 754 32 6.0 6.0 CD cord-014516-r59usk02 754 33 % % NN cord-014516-r59usk02 754 34 ) ) -RRB- cord-014516-r59usk02 754 35 . . . cord-014516-r59usk02 755 1 CRP CRP NNP cord-014516-r59usk02 755 2 concentrations concentration NNS cord-014516-r59usk02 755 3 were be VBD cord-014516-r59usk02 755 4 significantly significantly RB cord-014516-r59usk02 755 5 higher high JJR cord-014516-r59usk02 755 6 from from IN cord-014516-r59usk02 755 7 T0 T0 NNP cord-014516-r59usk02 755 8 ( ( -LRB- cord-014516-r59usk02 755 9 92.7 92.7 CD cord-014516-r59usk02 755 10 AE AE NNP cord-014516-r59usk02 755 11 113.7 113.7 CD cord-014516-r59usk02 755 12 mg mg NNP cord-014516-r59usk02 755 13 / / SYM cord-014516-r59usk02 755 14 L L NNP cord-014516-r59usk02 755 15 ) ) -RRB- cord-014516-r59usk02 755 16 to to IN cord-014516-r59usk02 755 17 T24 T24 NNP cord-014516-r59usk02 755 18 ( ( -LRB- cord-014516-r59usk02 755 19 95.2 95.2 CD cord-014516-r59usk02 755 20 AE AE NNP cord-014516-r59usk02 755 21 90.2 90.2 CD cord-014516-r59usk02 755 22 mg mg NNP cord-014516-r59usk02 755 23 / / SYM cord-014516-r59usk02 755 24 L L NNP cord-014516-r59usk02 755 25 ) ) -RRB- cord-014516-r59usk02 755 26 decreasing decrease VBG cord-014516-r59usk02 755 27 at at IN cord-014516-r59usk02 755 28 T72 T72 NNP cord-014516-r59usk02 755 29 ( ( -LRB- cord-014516-r59usk02 755 30 71.1 71.1 CD cord-014516-r59usk02 755 31 AE AE NNP cord-014516-r59usk02 755 32 76.6 76.6 CD cord-014516-r59usk02 755 33 mg mg NNP cord-014516-r59usk02 755 34 / / SYM cord-014516-r59usk02 755 35 L L NNP cord-014516-r59usk02 755 36 ) ) -RRB- cord-014516-r59usk02 755 37 , , , cord-014516-r59usk02 755 38 and and CC cord-014516-r59usk02 755 39 returning return VBG cord-014516-r59usk02 755 40 within within IN cord-014516-r59usk02 755 41 reference reference NN cord-014516-r59usk02 755 42 range range NN cord-014516-r59usk02 755 43 at at IN cord-014516-r59usk02 755 44 T1 T1 NNP cord-014516-r59usk02 755 45 m m NNP cord-014516-r59usk02 755 46 ( ( -LRB- cord-014516-r59usk02 755 47 2.4 2.4 CD cord-014516-r59usk02 755 48 AE AE NNP cord-014516-r59usk02 755 49 4.5 4.5 CD cord-014516-r59usk02 755 50 mg mg NNP cord-014516-r59usk02 755 51 / / SYM cord-014516-r59usk02 755 52 L L NNP cord-014516-r59usk02 755 53 ) ) -RRB- cord-014516-r59usk02 755 54 in in IN cord-014516-r59usk02 755 55 all all DT cord-014516-r59usk02 755 56 but but IN cord-014516-r59usk02 755 57 one one CD cord-014516-r59usk02 755 58 dog dog NN cord-014516-r59usk02 755 59 ( ( -LRB- cord-014516-r59usk02 755 60 18.2 18.2 CD cord-014516-r59usk02 755 61 mg mg NNP cord-014516-r59usk02 755 62 / / SYM cord-014516-r59usk02 755 63 L L NNP cord-014516-r59usk02 755 64 ) ) -RRB- cord-014516-r59usk02 755 65 . . . cord-014516-r59usk02 756 1 CRP CRP NNP cord-014516-r59usk02 756 2 was be VBD cord-014516-r59usk02 756 3 significantly significantly RB cord-014516-r59usk02 756 4 correlated correlate VBN cord-014516-r59usk02 756 5 with with IN cord-014516-r59usk02 756 6 logarithmical logarithmical JJ cord-014516-r59usk02 756 7 concentrations concentration NNS cord-014516-r59usk02 756 8 of of IN cord-014516-r59usk02 756 9 IL-6 IL-6 NNP cord-014516-r59usk02 756 10 and and CC cord-014516-r59usk02 756 11 TNF TNF NNP cord-014516-r59usk02 756 12 - - HYPH cord-014516-r59usk02 756 13 a a NNP cord-014516-r59usk02 756 14 , , , cord-014516-r59usk02 756 15 however however RB cord-014516-r59usk02 756 16 , , , cord-014516-r59usk02 756 17 these these DT cord-014516-r59usk02 756 18 did do VBD cord-014516-r59usk02 756 19 not not RB cord-014516-r59usk02 756 20 change change VB cord-014516-r59usk02 756 21 significantly significantly RB cord-014516-r59usk02 756 22 over over IN cord-014516-r59usk02 756 23 time time NN cord-014516-r59usk02 756 24 . . . cord-014516-r59usk02 757 1 None none NN cord-014516-r59usk02 757 2 of of IN cord-014516-r59usk02 757 3 the the DT cord-014516-r59usk02 757 4 evaluated evaluate VBN cord-014516-r59usk02 757 5 parameters parameter NNS cord-014516-r59usk02 757 6 was be VBD cord-014516-r59usk02 757 7 associated associate VBN cord-014516-r59usk02 757 8 with with IN cord-014516-r59usk02 757 9 disease disease NN cord-014516-r59usk02 757 10 category category NN cord-014516-r59usk02 757 11 , , , cord-014516-r59usk02 757 12 nor nor CC cord-014516-r59usk02 757 13 outcome outcome NN cord-014516-r59usk02 757 14 . . . cord-014516-r59usk02 758 1 CRP CRP NNP cord-014516-r59usk02 758 2 appears appear VBZ cord-014516-r59usk02 758 3 useful useful JJ cord-014516-r59usk02 758 4 to to TO cord-014516-r59usk02 758 5 diagnose diagnose VB cord-014516-r59usk02 758 6 SIRS sir NNS cord-014516-r59usk02 758 7 in in IN cord-014516-r59usk02 758 8 emergency emergency NN cord-014516-r59usk02 758 9 patients patient NNS cord-014516-r59usk02 758 10 , , , cord-014516-r59usk02 758 11 and and CC cord-014516-r59usk02 758 12 tends tend VBZ cord-014516-r59usk02 758 13 to to TO cord-014516-r59usk02 758 14 decrease decrease VB cord-014516-r59usk02 758 15 during during IN cord-014516-r59usk02 758 16 hospitalization hospitalization NN cord-014516-r59usk02 758 17 . . . cord-014516-r59usk02 759 1 However however RB cord-014516-r59usk02 759 2 , , , cord-014516-r59usk02 759 3 CRP CRP NNP cord-014516-r59usk02 759 4 , , , cord-014516-r59usk02 759 5 neither neither CC cord-014516-r59usk02 759 6 IL-6 IL-6 NNP cord-014516-r59usk02 759 7 nor nor CC cord-014516-r59usk02 759 8 TNF TNF NNP cord-014516-r59usk02 759 9 - - : cord-014516-r59usk02 759 10 a a DT cord-014516-r59usk02 759 11 concentrations concentration NNS cord-014516-r59usk02 759 12 appear appear VBP cord-014516-r59usk02 759 13 useful useful JJ cord-014516-r59usk02 759 14 to to TO cord-014516-r59usk02 759 15 predict predict VB cord-014516-r59usk02 759 16 the the DT cord-014516-r59usk02 759 17 underlying underlie VBG cord-014516-r59usk02 759 18 disease disease NN cord-014516-r59usk02 759 19 and and CC cord-014516-r59usk02 759 20 outcome outcome NN cord-014516-r59usk02 759 21 in in IN cord-014516-r59usk02 759 22 SIRS SIRS NNP cord-014516-r59usk02 759 23 patients patient NNS cord-014516-r59usk02 759 24 . . . cord-014516-r59usk02 760 1 No no DT cord-014516-r59usk02 760 2 conflicts conflict NNS cord-014516-r59usk02 760 3 of of IN cord-014516-r59usk02 760 4 interest interest NN cord-014516-r59usk02 760 5 reported report VBN cord-014516-r59usk02 760 6 . . . cord-014516-r59usk02 761 1 Calprotectin Calprotectin NNP cord-014516-r59usk02 761 2 ( ( -LRB- cord-014516-r59usk02 761 3 S100A8 S100A8 NNP cord-014516-r59usk02 761 4 / / SYM cord-014516-r59usk02 761 5 A9 A9 NNP cord-014516-r59usk02 761 6 complex complex NN cord-014516-r59usk02 761 7 ) ) -RRB- cord-014516-r59usk02 761 8 belongs belong VBZ cord-014516-r59usk02 761 9 to to IN cord-014516-r59usk02 761 10 the the DT cord-014516-r59usk02 761 11 S100 S100 NNP cord-014516-r59usk02 761 12 / / SYM cord-014516-r59usk02 761 13 calgranulin calgranulin NN cord-014516-r59usk02 761 14 family family NN cord-014516-r59usk02 761 15 , , , cord-014516-r59usk02 761 16 and and CC cord-014516-r59usk02 761 17 is be VBZ cord-014516-r59usk02 761 18 primarily primarily RB cord-014516-r59usk02 761 19 released release VBN cord-014516-r59usk02 761 20 from from IN cord-014516-r59usk02 761 21 activated activate VBN cord-014516-r59usk02 761 22 neutrophils neutrophil NNS cord-014516-r59usk02 761 23 and and CC cord-014516-r59usk02 761 24 macrophages macrophage NNS cord-014516-r59usk02 761 25 . . . cord-014516-r59usk02 762 1 Serum serum NN cord-014516-r59usk02 762 2 calprotectin calprotectin NN cord-014516-r59usk02 762 3 concentrations concentration NNS cord-014516-r59usk02 762 4 ( ( -LRB- cord-014516-r59usk02 762 5 CP CP NNP cord-014516-r59usk02 762 6 ) ) -RRB- cord-014516-r59usk02 762 7 were be VBD cord-014516-r59usk02 762 8 shown show VBN cord-014516-r59usk02 762 9 to to TO cord-014516-r59usk02 762 10 be be VB cord-014516-r59usk02 762 11 increased increase VBN cord-014516-r59usk02 762 12 in in IN cord-014516-r59usk02 762 13 dogs dog NNS cord-014516-r59usk02 762 14 with with IN cord-014516-r59usk02 762 15 inflammatory inflammatory JJ cord-014516-r59usk02 762 16 diseases disease NNS cord-014516-r59usk02 762 17 such such JJ cord-014516-r59usk02 762 18 as as IN cord-014516-r59usk02 762 19 inflammatory inflammatory JJ cord-014516-r59usk02 762 20 bowel bowel NN cord-014516-r59usk02 762 21 disease disease NN cord-014516-r59usk02 762 22 , , , cord-014516-r59usk02 762 23 pancreatitis pancreatitis NN cord-014516-r59usk02 762 24 , , , cord-014516-r59usk02 762 25 systemic systemic JJ cord-014516-r59usk02 762 26 inflammatory inflammatory JJ cord-014516-r59usk02 762 27 response response NN cord-014516-r59usk02 762 28 syndrome syndrome NN cord-014516-r59usk02 762 29 , , , cord-014516-r59usk02 762 30 and and CC cord-014516-r59usk02 762 31 sepsis sepsis NN cord-014516-r59usk02 762 32 . . . cord-014516-r59usk02 763 1 Canine canine JJ cord-014516-r59usk02 763 2 CP CP NNP cord-014516-r59usk02 763 3 thus thus RB cord-014516-r59usk02 763 4 appears appear VBZ cord-014516-r59usk02 763 5 to to TO cord-014516-r59usk02 763 6 be be VB cord-014516-r59usk02 763 7 a a DT cord-014516-r59usk02 763 8 biomarker biomarker NN cord-014516-r59usk02 763 9 of of IN cord-014516-r59usk02 763 10 inflammation inflammation NN cord-014516-r59usk02 763 11 . . . cord-014516-r59usk02 764 1 Considerable considerable JJ cord-014516-r59usk02 764 2 day day NN cord-014516-r59usk02 764 3 - - HYPH cord-014516-r59usk02 764 4 today today NN cord-014516-r59usk02 764 5 variation variation NN cord-014516-r59usk02 764 6 of of IN cord-014516-r59usk02 764 7 fecal fecal JJ cord-014516-r59usk02 764 8 canine canine JJ cord-014516-r59usk02 764 9 CP CP NNP cord-014516-r59usk02 764 10 was be VBD cord-014516-r59usk02 764 11 found find VBN cord-014516-r59usk02 764 12 in in IN cord-014516-r59usk02 764 13 both both DT cord-014516-r59usk02 764 14 healthy healthy JJ cord-014516-r59usk02 764 15 dogs dog NNS cord-014516-r59usk02 764 16 and and CC cord-014516-r59usk02 764 17 dogs dog NNS cord-014516-r59usk02 764 18 with with IN cord-014516-r59usk02 764 19 chronic chronic JJ cord-014516-r59usk02 764 20 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 764 21 disease disease NN cord-014516-r59usk02 764 22 . . . cord-014516-r59usk02 765 1 However however RB cord-014516-r59usk02 765 2 , , , cord-014516-r59usk02 765 3 the the DT cord-014516-r59usk02 765 4 biological biological JJ cord-014516-r59usk02 765 5 variation variation NN cord-014516-r59usk02 765 6 of of IN cord-014516-r59usk02 765 7 canine canine JJ cord-014516-r59usk02 765 8 CP cp NN cord-014516-r59usk02 765 9 in in IN cord-014516-r59usk02 765 10 serum serum NN cord-014516-r59usk02 765 11 has have VBZ cord-014516-r59usk02 765 12 not not RB cord-014516-r59usk02 765 13 been be VBN cord-014516-r59usk02 765 14 reported report VBN cord-014516-r59usk02 765 15 . . . cord-014516-r59usk02 766 1 The the DT cord-014516-r59usk02 766 2 aim aim NN cord-014516-r59usk02 766 3 of of IN cord-014516-r59usk02 766 4 this this DT cord-014516-r59usk02 766 5 study study NN cord-014516-r59usk02 766 6 was be VBD cord-014516-r59usk02 766 7 to to TO cord-014516-r59usk02 766 8 determine determine VB cord-014516-r59usk02 766 9 the the DT cord-014516-r59usk02 766 10 biological biological JJ cord-014516-r59usk02 766 11 variation variation NN cord-014516-r59usk02 766 12 of of IN cord-014516-r59usk02 766 13 serum serum NN cord-014516-r59usk02 766 14 canine canine JJ cord-014516-r59usk02 766 15 CP CP NNP cord-014516-r59usk02 766 16 and and CC cord-014516-r59usk02 766 17 its -PRON- PRP$ cord-014516-r59usk02 766 18 minimum minimum JJ cord-014516-r59usk02 766 19 critical critical JJ cord-014516-r59usk02 766 20 difference difference NN cord-014516-r59usk02 766 21 ( ( -LRB- cord-014516-r59usk02 766 22 MCD MCD NNP cord-014516-r59usk02 766 23 ) ) -RRB- cord-014516-r59usk02 766 24 . . . cord-014516-r59usk02 767 1 Eleven eleven CD cord-014516-r59usk02 767 2 healthy healthy JJ cord-014516-r59usk02 767 3 dogs dog NNS cord-014516-r59usk02 767 4 were be VBD cord-014516-r59usk02 767 5 used use VBN cord-014516-r59usk02 767 6 for for IN cord-014516-r59usk02 767 7 this this DT cord-014516-r59usk02 767 8 study study NN cord-014516-r59usk02 767 9 . . . cord-014516-r59usk02 768 1 Biological biological JJ cord-014516-r59usk02 768 2 variation variation NN cord-014516-r59usk02 768 3 of of IN cord-014516-r59usk02 768 4 serum serum NN cord-014516-r59usk02 768 5 canine canine JJ cord-014516-r59usk02 768 6 CP CP NNP cord-014516-r59usk02 768 7 was be VBD cord-014516-r59usk02 768 8 evaluated evaluate VBN cord-014516-r59usk02 768 9 over over IN cord-014516-r59usk02 768 10 a a DT cord-014516-r59usk02 768 11 2.6-months 2.6-months CD cord-014516-r59usk02 768 12 period period NN cord-014516-r59usk02 768 13 . . . cord-014516-r59usk02 769 1 Tests test NNS cord-014516-r59usk02 769 2 for for IN cord-014516-r59usk02 769 3 outliers outlier NNS cord-014516-r59usk02 769 4 were be VBD cord-014516-r59usk02 769 5 carried carry VBN cord-014516-r59usk02 769 6 out out RP cord-014516-r59usk02 769 7 at at IN cord-014516-r59usk02 769 8 3 3 CD cord-014516-r59usk02 769 9 levels level NNS cord-014516-r59usk02 769 10 ( ( -LRB- cord-014516-r59usk02 769 11 within within IN cord-014516-r59usk02 769 12 - - HYPH cord-014516-r59usk02 769 13 run run NN cord-014516-r59usk02 769 14 analytical analytical JJ cord-014516-r59usk02 769 15 variance variance NN cord-014516-r59usk02 769 16 , , , cord-014516-r59usk02 769 17 intra- intra- NN cord-014516-r59usk02 769 18 , , , cord-014516-r59usk02 769 19 and and CC cord-014516-r59usk02 769 20 inter inter JJ cord-014516-r59usk02 769 21 - - JJ cord-014516-r59usk02 769 22 individual individual JJ cord-014516-r59usk02 769 23 variation variation NN cord-014516-r59usk02 769 24 ) ) -RRB- cord-014516-r59usk02 769 25 . . . cord-014516-r59usk02 770 1 A a DT cord-014516-r59usk02 770 2 nested nested JJ cord-014516-r59usk02 770 3 analysis analysis NN cord-014516-r59usk02 770 4 of of IN cord-014516-r59usk02 770 5 variance variance NN cord-014516-r59usk02 770 6 ( ( -LRB- cord-014516-r59usk02 770 7 ANOVA ANOVA NNP cord-014516-r59usk02 770 8 ) ) -RRB- cord-014516-r59usk02 770 9 model model NN cord-014516-r59usk02 770 10 was be VBD cord-014516-r59usk02 770 11 used use VBN cord-014516-r59usk02 770 12 to to TO cord-014516-r59usk02 770 13 calculate calculate VB cord-014516-r59usk02 770 14 analytical analytical JJ cord-014516-r59usk02 770 15 ( ( -LRB- cord-014516-r59usk02 770 16 CV CV NNP cord-014516-r59usk02 770 17 A A NNP cord-014516-r59usk02 770 18 ) ) -RRB- cord-014516-r59usk02 770 19 , , , cord-014516-r59usk02 770 20 intra intra JJ cord-014516-r59usk02 770 21 - - JJ cord-014516-r59usk02 770 22 individual individual JJ cord-014516-r59usk02 770 23 ( ( -LRB- cord-014516-r59usk02 770 24 CV cv NN cord-014516-r59usk02 770 25 I i CD cord-014516-r59usk02 770 26 ) ) -RRB- cord-014516-r59usk02 770 27 , , , cord-014516-r59usk02 770 28 inter inter JJ cord-014516-r59usk02 770 29 - - JJ cord-014516-r59usk02 770 30 individual individual JJ cord-014516-r59usk02 770 31 ( ( -LRB- cord-014516-r59usk02 770 32 CV CV NNP cord-014516-r59usk02 770 33 G G NNP cord-014516-r59usk02 770 34 ) ) -RRB- cord-014516-r59usk02 770 35 , , , cord-014516-r59usk02 770 36 and and CC cord-014516-r59usk02 770 37 total total JJ cord-014516-r59usk02 770 38 variation variation NN cord-014516-r59usk02 770 39 ( ( -LRB- cord-014516-r59usk02 770 40 CV CV NNP cord-014516-r59usk02 770 41 T T NNP cord-014516-r59usk02 770 42 ) ) -RRB- cord-014516-r59usk02 770 43 , , , cord-014516-r59usk02 770 44 and and CC cord-014516-r59usk02 770 45 to to TO cord-014516-r59usk02 770 46 determine determine VB cord-014516-r59usk02 770 47 the the DT cord-014516-r59usk02 770 48 index index NN cord-014516-r59usk02 770 49 of of IN cord-014516-r59usk02 770 50 individuality individuality NN cord-014516-r59usk02 770 51 ( ( -LRB- cord-014516-r59usk02 770 52 II II NNP cord-014516-r59usk02 770 53 ) ) -RRB- cord-014516-r59usk02 770 54 , , , cord-014516-r59usk02 770 55 index index NN cord-014516-r59usk02 770 56 of of IN cord-014516-r59usk02 770 57 heterogeneity heterogeneity NN cord-014516-r59usk02 770 58 ( ( -LRB- cord-014516-r59usk02 770 59 IH IH NNP cord-014516-r59usk02 770 60 ) ) -RRB- cord-014516-r59usk02 770 61 , , , cord-014516-r59usk02 770 62 and and CC cord-014516-r59usk02 770 63 MCD MCD NNP cord-014516-r59usk02 770 64 . . . cord-014516-r59usk02 771 1 A a DT cord-014516-r59usk02 771 2 total total NN cord-014516-r59usk02 771 3 of of IN cord-014516-r59usk02 771 4 14 14 CD cord-014516-r59usk02 771 5 serial serial JJ cord-014516-r59usk02 771 6 specimens specimen NNS cord-014516-r59usk02 771 7 were be VBD cord-014516-r59usk02 771 8 collected collect VBN cord-014516-r59usk02 771 9 from from IN cord-014516-r59usk02 771 10 6 6 CD cord-014516-r59usk02 771 11 dogs dog NNS cord-014516-r59usk02 771 12 , , , cord-014516-r59usk02 771 13 13 13 CD cord-014516-r59usk02 771 14 serial serial JJ cord-014516-r59usk02 771 15 samples sample NNS cord-014516-r59usk02 771 16 from from IN cord-014516-r59usk02 771 17 3 3 CD cord-014516-r59usk02 771 18 dogs dog NNS cord-014516-r59usk02 771 19 , , , cord-014516-r59usk02 771 20 and and CC cord-014516-r59usk02 771 21 12 12 CD cord-014516-r59usk02 771 22 serial serial JJ cord-014516-r59usk02 771 23 samples sample NNS cord-014516-r59usk02 771 24 from from IN cord-014516-r59usk02 771 25 2 2 CD cord-014516-r59usk02 771 26 dogs dog NNS cord-014516-r59usk02 771 27 . . . cord-014516-r59usk02 772 1 Four four CD cord-014516-r59usk02 772 2 within within IN cord-014516-r59usk02 772 3 - - HYPH cord-014516-r59usk02 772 4 subject subject NN cord-014516-r59usk02 772 5 outliers outlier NNS cord-014516-r59usk02 772 6 were be VBD cord-014516-r59usk02 772 7 detected detect VBN cord-014516-r59usk02 772 8 and and CC cord-014516-r59usk02 772 9 excluded exclude VBN cord-014516-r59usk02 772 10 from from IN cord-014516-r59usk02 772 11 further further JJ cord-014516-r59usk02 772 12 analysis analysis NN cord-014516-r59usk02 772 13 , , , cord-014516-r59usk02 772 14 yielding yield VBG cord-014516-r59usk02 772 15 a a DT cord-014516-r59usk02 772 16 total total NN cord-014516-r59usk02 772 17 of of IN cord-014516-r59usk02 772 18 147 147 CD cord-014516-r59usk02 772 19 serum serum NN cord-014516-r59usk02 772 20 samples sample NNS cord-014516-r59usk02 772 21 and and CC cord-014516-r59usk02 772 22 slightly slightly RB cord-014516-r59usk02 772 23 right right RB cord-014516-r59usk02 772 24 - - HYPH cord-014516-r59usk02 772 25 skewed skewed JJ cord-014516-r59usk02 772 26 data datum NNS cord-014516-r59usk02 772 27 . . . cord-014516-r59usk02 773 1 No no DT cord-014516-r59usk02 773 2 outlying outlying JJ cord-014516-r59usk02 773 3 observations observation NNS cord-014516-r59usk02 773 4 ( ( -LRB- cord-014516-r59usk02 773 5 Cochrane Cochrane NNP cord-014516-r59usk02 773 6 test test NN cord-014516-r59usk02 773 7 ) ) -RRB- cord-014516-r59usk02 773 8 or or CC cord-014516-r59usk02 773 9 outliers outlier NNS cord-014516-r59usk02 773 10 among among IN cord-014516-r59usk02 773 11 mean mean JJ cord-014516-r59usk02 773 12 concentrations concentration NNS cord-014516-r59usk02 773 13 of of IN cord-014516-r59usk02 773 14 subjects subject NNS cord-014516-r59usk02 773 15 ( ( -LRB- cord-014516-r59usk02 773 16 Reed Reed NNP cord-014516-r59usk02 773 17 's 's POS cord-014516-r59usk02 773 18 criterion criterion NN cord-014516-r59usk02 773 19 ) ) -RRB- cord-014516-r59usk02 773 20 were be VBD cord-014516-r59usk02 773 21 detected detect VBN cord-014516-r59usk02 773 22 . . . cord-014516-r59usk02 774 1 CV CV NNP cord-014516-r59usk02 774 2 A A NNP cord-014516-r59usk02 774 3 was be VBD cord-014516-r59usk02 774 4 calculated calculate VBN cord-014516-r59usk02 774 5 as as IN cord-014516-r59usk02 774 6 3.0 3.0 CD cord-014516-r59usk02 774 7 % % NN cord-014516-r59usk02 774 8 , , , cord-014516-r59usk02 774 9 CV CV NNP cord-014516-r59usk02 774 10 I -PRON- PRP cord-014516-r59usk02 774 11 as as IN cord-014516-r59usk02 774 12 29.9 29.9 CD cord-014516-r59usk02 774 13 % % NN cord-014516-r59usk02 774 14 , , , cord-014516-r59usk02 774 15 and and CC cord-014516-r59usk02 774 16 CV CV NNP cord-014516-r59usk02 774 17 G G NNP cord-014516-r59usk02 774 18 as as IN cord-014516-r59usk02 774 19 33.2 33.2 CD cord-014516-r59usk02 774 20 % % NN cord-014516-r59usk02 774 21 , , , cord-014516-r59usk02 774 22 resulting result VBG cord-014516-r59usk02 774 23 in in IN cord-014516-r59usk02 774 24 a a DT cord-014516-r59usk02 774 25 CV CV NNP cord-014516-r59usk02 774 26 T t NN cord-014516-r59usk02 774 27 of of IN cord-014516-r59usk02 774 28 66.1 66.1 CD cord-014516-r59usk02 774 29 % % NN cord-014516-r59usk02 774 30 . . . cord-014516-r59usk02 775 1 Index index NN cord-014516-r59usk02 775 2 of of IN cord-014516-r59usk02 775 3 Individuality Individuality NNP cord-014516-r59usk02 775 4 ( ( -LRB- cord-014516-r59usk02 775 5 II II NNP cord-014516-r59usk02 775 6 ) ) -RRB- cord-014516-r59usk02 775 7 was be VBD cord-014516-r59usk02 775 8 determined determine VBN cord-014516-r59usk02 775 9 to to TO cord-014516-r59usk02 775 10 be be VB cord-014516-r59usk02 775 11 0.905 0.905 CD cord-014516-r59usk02 775 12 and and CC cord-014516-r59usk02 775 13 IH IH NNP cord-014516-r59usk02 775 14 was be VBD cord-014516-r59usk02 775 15 4.939 4.939 CD cord-014516-r59usk02 775 16 , , , cord-014516-r59usk02 775 17 yielding yield VBG cord-014516-r59usk02 775 18 a a DT cord-014516-r59usk02 775 19 one one CD cord-014516-r59usk02 775 20 - - HYPH cord-014516-r59usk02 775 21 sided sided JJ cord-014516-r59usk02 775 22 MCD MCD NNP cord-014516-r59usk02 775 23 of of IN cord-014516-r59usk02 775 24 6.4 6.4 CD cord-014516-r59usk02 775 25 mg mg NNP cord-014516-r59usk02 775 26 / / SYM cord-014516-r59usk02 775 27 L. L. NNP cord-014516-r59usk02 776 1 The the DT cord-014516-r59usk02 776 2 analytical analytical JJ cord-014516-r59usk02 776 3 goal goal NN cord-014516-r59usk02 776 4 of of IN cord-014516-r59usk02 776 5 CV CV NNP cord-014516-r59usk02 776 6 A A NNP cord-014516-r59usk02 776 7 ≤ ≤ NN cord-014516-r59usk02 776 8 ½9CV ½9cv NN cord-014516-r59usk02 777 1 I -PRON- PRP cord-014516-r59usk02 777 2 was be VBD cord-014516-r59usk02 777 3 satisfied satisfied JJ cord-014516-r59usk02 777 4 . . . cord-014516-r59usk02 778 1 Although although IN cord-014516-r59usk02 778 2 serum serum NN cord-014516-r59usk02 778 3 canine canine JJ cord-014516-r59usk02 778 4 CP cp NN cord-014516-r59usk02 778 5 remained remain VBD cord-014516-r59usk02 778 6 within within IN cord-014516-r59usk02 778 7 a a DT cord-014516-r59usk02 778 8 relatively relatively RB cord-014516-r59usk02 778 9 narrow narrow JJ cord-014516-r59usk02 778 10 concentration concentration NN cord-014516-r59usk02 778 11 range range NN cord-014516-r59usk02 778 12 in in IN cord-014516-r59usk02 778 13 healthy healthy JJ cord-014516-r59usk02 778 14 dogs dog NNS cord-014516-r59usk02 778 15 , , , cord-014516-r59usk02 778 16 moderate moderate JJ cord-014516-r59usk02 778 17 individuality individuality NN cord-014516-r59usk02 778 18 was be VBD cord-014516-r59usk02 778 19 detected detect VBN cord-014516-r59usk02 778 20 . . . cord-014516-r59usk02 779 1 Moderate moderate JJ cord-014516-r59usk02 779 2 changes change NNS cord-014516-r59usk02 779 3 in in IN cord-014516-r59usk02 779 4 serum serum NN cord-014516-r59usk02 779 5 canine canine JJ cord-014516-r59usk02 779 6 CP cp NN cord-014516-r59usk02 779 7 ( ( -LRB- cord-014516-r59usk02 779 8 6.4 6.4 CD cord-014516-r59usk02 779 9 mg mg NNP cord-014516-r59usk02 779 10 / / SYM cord-014516-r59usk02 779 11 L L NNP cord-014516-r59usk02 779 12 ) ) -RRB- cord-014516-r59usk02 779 13 between between IN cord-014516-r59usk02 779 14 sequential sequential JJ cord-014516-r59usk02 779 15 measurements measurement NNS cord-014516-r59usk02 779 16 are be VBP cord-014516-r59usk02 779 17 needed need VBN cord-014516-r59usk02 779 18 to to TO cord-014516-r59usk02 779 19 be be VB cord-014516-r59usk02 779 20 considered consider VBN cord-014516-r59usk02 779 21 clinically clinically RB cord-014516-r59usk02 779 22 relevant relevant JJ cord-014516-r59usk02 779 23 , , , cord-014516-r59usk02 779 24 and and CC cord-014516-r59usk02 779 25 using use VBG cord-014516-r59usk02 779 26 a a DT cord-014516-r59usk02 779 27 population population NN cord-014516-r59usk02 779 28 - - HYPH cord-014516-r59usk02 779 29 based base VBN cord-014516-r59usk02 779 30 reference reference NN cord-014516-r59usk02 779 31 interval interval NN cord-014516-r59usk02 779 32 may may MD cord-014516-r59usk02 779 33 or or CC cord-014516-r59usk02 779 34 may may MD cord-014516-r59usk02 779 35 not not RB cord-014516-r59usk02 779 36 be be VB cord-014516-r59usk02 779 37 appropriate appropriate JJ cord-014516-r59usk02 779 38 for for IN cord-014516-r59usk02 779 39 serum serum NN cord-014516-r59usk02 779 40 canine canine JJ cord-014516-r59usk02 779 41 CP cp NN cord-014516-r59usk02 779 42 . . . cord-014516-r59usk02 780 1 Using use VBG cord-014516-r59usk02 780 2 the the DT cord-014516-r59usk02 780 3 MCD MCD NNP cord-014516-r59usk02 780 4 with with IN cord-014516-r59usk02 780 5 the the DT cord-014516-r59usk02 780 6 previously previously RB cord-014516-r59usk02 780 7 determined determined JJ cord-014516-r59usk02 780 8 median median JJ cord-014516-r59usk02 780 9 canine canine JJ cord-014516-r59usk02 780 10 CP cp NN cord-014516-r59usk02 780 11 concentration concentration NN cord-014516-r59usk02 780 12 ( ( -LRB- cord-014516-r59usk02 780 13 4.9 4.9 CD cord-014516-r59usk02 780 14 mg mg NNP cord-014516-r59usk02 780 15 / / SYM cord-014516-r59usk02 780 16 L L NNP cord-014516-r59usk02 780 17 ) ) -RRB- cord-014516-r59usk02 780 18 for for IN cord-014516-r59usk02 780 19 the the DT cord-014516-r59usk02 780 20 reference reference NN cord-014516-r59usk02 780 21 sample sample NN cord-014516-r59usk02 780 22 group group NN cord-014516-r59usk02 780 23 yielded yield VBD cord-014516-r59usk02 780 24 a a DT cord-014516-r59usk02 780 25 serum serum NN cord-014516-r59usk02 780 26 canine canine JJ cord-014516-r59usk02 780 27 CP cp NN cord-014516-r59usk02 780 28 concentration concentration NN cord-014516-r59usk02 780 29 close close RB cord-014516-r59usk02 780 30 to to IN cord-014516-r59usk02 780 31 the the DT cord-014516-r59usk02 780 32 upper upper JJ cord-014516-r59usk02 780 33 limit limit NN cord-014516-r59usk02 780 34 of of IN cord-014516-r59usk02 780 35 the the DT cord-014516-r59usk02 780 36 previously previously RB cord-014516-r59usk02 780 37 established establish VBN cord-014516-r59usk02 780 38 reference reference NN cord-014516-r59usk02 780 39 interval interval NN cord-014516-r59usk02 780 40 ( ( -LRB- cord-014516-r59usk02 780 41 11.9 11.9 CD cord-014516-r59usk02 780 42 mg mg NNP cord-014516-r59usk02 780 43 / / SYM cord-014516-r59usk02 780 44 L L NNP cord-014516-r59usk02 780 45 ) ) -RRB- cord-014516-r59usk02 780 46 , , , cord-014516-r59usk02 780 47 showing show VBG cord-014516-r59usk02 780 48 that that IN cord-014516-r59usk02 780 49 the the DT cord-014516-r59usk02 780 50 reference reference NN cord-014516-r59usk02 780 51 interval interval NN cord-014516-r59usk02 780 52 for for IN cord-014516-r59usk02 780 53 serum serum NN cord-014516-r59usk02 780 54 cCP ccp CD cord-014516-r59usk02 780 55 ( ( -LRB- cord-014516-r59usk02 780 56 0.9 0.9 CD cord-014516-r59usk02 780 57 - - SYM cord-014516-r59usk02 780 58 11.9 11.9 CD cord-014516-r59usk02 780 59 mg mg NNP cord-014516-r59usk02 780 60 / / SYM cord-014516-r59usk02 780 61 L L NNP cord-014516-r59usk02 780 62 ) ) -RRB- cord-014516-r59usk02 780 63 is be VBZ cord-014516-r59usk02 780 64 within within IN cord-014516-r59usk02 780 65 reasonable reasonable JJ cord-014516-r59usk02 780 66 limits limit NNS cord-014516-r59usk02 780 67 . . . cord-014516-r59usk02 781 1 The the DT cord-014516-r59usk02 781 2 assay assay NN cord-014516-r59usk02 781 3 used use VBN cord-014516-r59usk02 781 4 in in IN cord-014516-r59usk02 781 5 the the DT cord-014516-r59usk02 781 6 study study NN cord-014516-r59usk02 781 7 was be VBD cord-014516-r59usk02 781 8 developed develop VBN cord-014516-r59usk02 781 9 at at IN cord-014516-r59usk02 781 10 the the DT cord-014516-r59usk02 781 11 GI GI NNP cord-014516-r59usk02 781 12 Laboratory Laboratory NNP cord-014516-r59usk02 781 13 , , , cord-014516-r59usk02 781 14 Texas Texas NNP cord-014516-r59usk02 781 15 A&M A&M NNP cord-014516-r59usk02 781 16 University University NNP cord-014516-r59usk02 781 17 . . . cord-014516-r59usk02 782 1 Most Most JJS cord-014516-r59usk02 782 2 authors author NNS cord-014516-r59usk02 782 3 also also RB cord-014516-r59usk02 782 4 work work VBP cord-014516-r59usk02 782 5 at at IN cord-014516-r59usk02 782 6 the the DT cord-014516-r59usk02 782 7 GI GI NNP cord-014516-r59usk02 782 8 Laboratory Laboratory NNP cord-014516-r59usk02 782 9 , , , cord-014516-r59usk02 782 10 Texa Texa NNP cord-014516-r59usk02 782 11 A&M A&M NNP cord-014516-r59usk02 782 12 University University NNP cord-014516-r59usk02 782 13 . . . cord-014516-r59usk02 783 1 Canine canine JJ cord-014516-r59usk02 783 2 leishmaniasis leishmaniasis NN cord-014516-r59usk02 783 3 ( ( -LRB- cord-014516-r59usk02 783 4 CanL CanL NNP cord-014516-r59usk02 783 5 ) ) -RRB- cord-014516-r59usk02 783 6 is be VBZ cord-014516-r59usk02 783 7 a a DT cord-014516-r59usk02 783 8 multisystemic multisystemic JJ cord-014516-r59usk02 783 9 disease disease NN cord-014516-r59usk02 783 10 that that WDT cord-014516-r59usk02 783 11 is be VBZ cord-014516-r59usk02 783 12 endemic endemic JJ cord-014516-r59usk02 783 13 in in IN cord-014516-r59usk02 783 14 the the DT cord-014516-r59usk02 783 15 Mediterranean Mediterranean NNP cord-014516-r59usk02 783 16 region region NN cord-014516-r59usk02 783 17 . . . cord-014516-r59usk02 784 1 In in IN cord-014516-r59usk02 784 2 the the DT cord-014516-r59usk02 784 3 past past NN cord-014516-r59usk02 784 4 , , , cord-014516-r59usk02 784 5 concentrations concentration NNS cord-014516-r59usk02 784 6 of of IN cord-014516-r59usk02 784 7 acute acute JJ cord-014516-r59usk02 784 8 phase phase NN cord-014516-r59usk02 784 9 proteins protein NNS cord-014516-r59usk02 784 10 ( ( -LRB- cord-014516-r59usk02 784 11 APPs app NNS cord-014516-r59usk02 784 12 ) ) -RRB- cord-014516-r59usk02 784 13 , , , cord-014516-r59usk02 784 14 and and CC cord-014516-r59usk02 784 15 specifically specifically RB cord-014516-r59usk02 784 16 C c NN cord-014516-r59usk02 784 17 - - HYPH cord-014516-r59usk02 784 18 reactive reactive JJ cord-014516-r59usk02 784 19 protein protein NN cord-014516-r59usk02 784 20 ( ( -LRB- cord-014516-r59usk02 784 21 CRP CRP NNP cord-014516-r59usk02 784 22 ) ) -RRB- cord-014516-r59usk02 784 23 , , , cord-014516-r59usk02 784 24 haptoglobin haptoglobin NN cord-014516-r59usk02 784 25 ( ( -LRB- cord-014516-r59usk02 784 26 Hp Hp NNP cord-014516-r59usk02 784 27 ) ) -RRB- cord-014516-r59usk02 784 28 , , , cord-014516-r59usk02 784 29 ceruloplasmin ceruloplasmin NNP cord-014516-r59usk02 784 30 ( ( -LRB- cord-014516-r59usk02 784 31 Cp Cp NNP cord-014516-r59usk02 784 32 ) ) -RRB- cord-014516-r59usk02 784 33 , , . cord-014516-r59usk02 785 1 serum serum NN cord-014516-r59usk02 785 2 amyloid amyloid NNP cord-014516-r59usk02 785 3 A A NNP cord-014516-r59usk02 785 4 ( ( -LRB- cord-014516-r59usk02 785 5 SAA SAA NNP cord-014516-r59usk02 785 6 ) ) -RRB- cord-014516-r59usk02 785 7 and and CC cord-014516-r59usk02 785 8 albumin albumin NN cord-014516-r59usk02 785 9 ( ( -LRB- cord-014516-r59usk02 785 10 Alb Alb NNP cord-014516-r59usk02 785 11 ) ) -RRB- cord-014516-r59usk02 785 12 , , , cord-014516-r59usk02 785 13 have have VBP cord-014516-r59usk02 785 14 been be VBN cord-014516-r59usk02 785 15 reported report VBN cord-014516-r59usk02 785 16 to to TO cord-014516-r59usk02 785 17 change change VB cord-014516-r59usk02 785 18 in in IN cord-014516-r59usk02 785 19 dogs dog NNS cord-014516-r59usk02 785 20 with with IN cord-014516-r59usk02 785 21 leishmaniasis leishmaniasis NN cord-014516-r59usk02 785 22 , , , cord-014516-r59usk02 785 23 and and CC cord-014516-r59usk02 785 24 revert revert VB cord-014516-r59usk02 785 25 to to IN cord-014516-r59usk02 785 26 normal normal JJ cord-014516-r59usk02 785 27 after after IN cord-014516-r59usk02 785 28 successful successful JJ cord-014516-r59usk02 785 29 treatment treatment NN cord-014516-r59usk02 785 30 , , , cord-014516-r59usk02 785 31 highlighting highlight VBG cord-014516-r59usk02 785 32 the the DT cord-014516-r59usk02 785 33 intrinsic intrinsic JJ cord-014516-r59usk02 785 34 inflammatory inflammatory JJ cord-014516-r59usk02 785 35 reaction reaction NN cord-014516-r59usk02 785 36 of of IN cord-014516-r59usk02 785 37 the the DT cord-014516-r59usk02 785 38 host host NN cord-014516-r59usk02 785 39 to to IN cord-014516-r59usk02 785 40 the the DT cord-014516-r59usk02 785 41 parasite parasite NN cord-014516-r59usk02 785 42 . . . cord-014516-r59usk02 786 1 Since since IN cord-014516-r59usk02 786 2 the the DT cord-014516-r59usk02 786 3 spectrum spectrum NN cord-014516-r59usk02 786 4 of of IN cord-014516-r59usk02 786 5 clinical clinical JJ cord-014516-r59usk02 786 6 and and CC cord-014516-r59usk02 786 7 laboratory laboratory NN cord-014516-r59usk02 786 8 derangements derangement NNS cord-014516-r59usk02 786 9 is be VBZ cord-014516-r59usk02 786 10 broad broad JJ cord-014516-r59usk02 786 11 , , , cord-014516-r59usk02 786 12 it -PRON- PRP cord-014516-r59usk02 786 13 is be VBZ cord-014516-r59usk02 786 14 possible possible JJ cord-014516-r59usk02 786 15 that that IN cord-014516-r59usk02 786 16 APPs app NNS cord-014516-r59usk02 786 17 are be VBP cord-014516-r59usk02 786 18 increased increase VBN cord-014516-r59usk02 786 19 specifically specifically RB cord-014516-r59usk02 786 20 because because IN cord-014516-r59usk02 786 21 of of IN cord-014516-r59usk02 786 22 certain certain JJ cord-014516-r59usk02 786 23 clinicopathological clinicopathological JJ cord-014516-r59usk02 786 24 syndromes syndrome NNS cord-014516-r59usk02 786 25 associated associate VBN cord-014516-r59usk02 786 26 with with IN cord-014516-r59usk02 786 27 CanL. CanL. NNP cord-014516-r59usk02 787 1 A a DT cord-014516-r59usk02 787 2 total total NN cord-014516-r59usk02 787 3 of of IN cord-014516-r59usk02 787 4 80 80 CD cord-014516-r59usk02 787 5 dogs dog NNS cord-014516-r59usk02 787 6 with with IN cord-014516-r59usk02 787 7 CanL CanL NNP cord-014516-r59usk02 787 8 , , , cord-014516-r59usk02 787 9 diagnosed diagnose VBN cord-014516-r59usk02 787 10 on on IN cord-014516-r59usk02 787 11 the the DT cord-014516-r59usk02 787 12 basis basis NN cord-014516-r59usk02 787 13 of of IN cord-014516-r59usk02 787 14 cytological cytological NNP cord-014516-r59usk02 787 15 amastigote amastigote NNP cord-014516-r59usk02 787 16 identification identification NN cord-014516-r59usk02 787 17 and and CC cord-014516-r59usk02 787 18 IFAT ifat NN cord-014516-r59usk02 787 19 serology serology NN cord-014516-r59usk02 787 20 , , , cord-014516-r59usk02 787 21 were be VBD cord-014516-r59usk02 787 22 retrospectively retrospectively RB cord-014516-r59usk02 787 23 included include VBN cord-014516-r59usk02 787 24 in in IN cord-014516-r59usk02 787 25 the the DT cord-014516-r59usk02 787 26 study study NN cord-014516-r59usk02 787 27 . . . cord-014516-r59usk02 788 1 In in IN cord-014516-r59usk02 788 2 all all DT cord-014516-r59usk02 788 3 of of IN cord-014516-r59usk02 788 4 them -PRON- PRP cord-014516-r59usk02 788 5 , , , cord-014516-r59usk02 788 6 CRP CRP NNP cord-014516-r59usk02 788 7 , , , cord-014516-r59usk02 788 8 SAA SAA NNP cord-014516-r59usk02 788 9 , , , cord-014516-r59usk02 788 10 Hp Hp NNP cord-014516-r59usk02 788 11 and and CC cord-014516-r59usk02 788 12 Alb Alb NNP cord-014516-r59usk02 788 13 were be VBD cord-014516-r59usk02 788 14 measured measure VBN cord-014516-r59usk02 788 15 at at IN cord-014516-r59usk02 788 16 Interlab Interlab NNP cord-014516-r59usk02 788 17 - - HYPH cord-014516-r59usk02 788 18 UMU UMU NNP cord-014516-r59usk02 788 19 , , , cord-014516-r59usk02 788 20 Murcia Murcia NNP cord-014516-r59usk02 788 21 , , , cord-014516-r59usk02 788 22 Spain Spain NNP cord-014516-r59usk02 788 23 , , , cord-014516-r59usk02 788 24 in in IN cord-014516-r59usk02 788 25 aliquots aliquot NNS cord-014516-r59usk02 788 26 of of IN cord-014516-r59usk02 788 27 serum serum NN cord-014516-r59usk02 788 28 , , , cord-014516-r59usk02 788 29 which which WDT cord-014516-r59usk02 788 30 were be VBD cord-014516-r59usk02 788 31 stored store VBN cord-014516-r59usk02 788 32 in in IN cord-014516-r59usk02 788 33 -22 -22 DT cord-014516-r59usk02 788 34 ° ° NN cord-014516-r59usk02 788 35 C c NN cord-014516-r59usk02 788 36 for for IN cord-014516-r59usk02 788 37 4 4 CD cord-014516-r59usk02 788 38 -8 -8 CD cord-014516-r59usk02 788 39 years year NNS cord-014516-r59usk02 788 40 ( ( -LRB- cord-014516-r59usk02 788 41 median median NN cord-014516-r59usk02 788 42 : : : cord-014516-r59usk02 788 43 4 4 CD cord-014516-r59usk02 788 44 years year NNS cord-014516-r59usk02 788 45 ) ) -RRB- cord-014516-r59usk02 788 46 . . . cord-014516-r59usk02 789 1 Results result NNS cord-014516-r59usk02 789 2 for for IN cord-014516-r59usk02 789 3 each each DT cord-014516-r59usk02 789 4 of of IN cord-014516-r59usk02 789 5 the the DT cord-014516-r59usk02 789 6 APPs app NNS cord-014516-r59usk02 789 7 were be VBD cord-014516-r59usk02 789 8 correlated correlate VBN cord-014516-r59usk02 789 9 to to IN cord-014516-r59usk02 789 10 laboratory laboratory NN cord-014516-r59usk02 789 11 and and CC cord-014516-r59usk02 789 12 clinical clinical JJ cord-014516-r59usk02 789 13 parameters parameter NNS cord-014516-r59usk02 789 14 ( ( -LRB- cord-014516-r59usk02 789 15 n:80 n:80 CD cord-014516-r59usk02 789 16 ) ) -RRB- cord-014516-r59usk02 789 17 , , , cord-014516-r59usk02 789 18 clinical clinical JJ cord-014516-r59usk02 789 19 and and CC cord-014516-r59usk02 789 20 parasitological parasitological JJ cord-014516-r59usk02 789 21 scoring scoring NN cord-014516-r59usk02 789 22 ( ( -LRB- cord-014516-r59usk02 789 23 n:40 n:40 NNP cord-014516-r59usk02 789 24 ) ) -RRB- cord-014516-r59usk02 789 25 , , , cord-014516-r59usk02 789 26 Ehrlichia Ehrlichia NNP cord-014516-r59usk02 789 27 and and CC cord-014516-r59usk02 789 28 Leishmania Leishmania NNP cord-014516-r59usk02 789 29 serology serology NN cord-014516-r59usk02 789 30 ( ( -LRB- cord-014516-r59usk02 789 31 n:40 n:40 NNP cord-014516-r59usk02 789 32 ) ) -RRB- cord-014516-r59usk02 789 33 , , , cord-014516-r59usk02 789 34 and and CC cord-014516-r59usk02 789 35 clinical clinical JJ cord-014516-r59usk02 789 36 staging staging NN cord-014516-r59usk02 789 37 according accord VBG cord-014516-r59usk02 789 38 to to IN cord-014516-r59usk02 789 39 LeishVet LeishVet NNP cord-014516-r59usk02 789 40 ( ( -LRB- cord-014516-r59usk02 789 41 n:80 n:80 CD cord-014516-r59usk02 789 42 ) ) -RRB- cord-014516-r59usk02 789 43 , , , cord-014516-r59usk02 789 44 using use VBG cord-014516-r59usk02 789 45 an an DT cord-014516-r59usk02 789 46 array array NN cord-014516-r59usk02 789 47 of of IN cord-014516-r59usk02 789 48 linear linear JJ cord-014516-r59usk02 789 49 and and CC cord-014516-r59usk02 789 50 ordinal ordinal JJ cord-014516-r59usk02 789 51 regression regression NN cord-014516-r59usk02 789 52 models model NNS cord-014516-r59usk02 789 53 , , , cord-014516-r59usk02 789 54 as as RB cord-014516-r59usk02 789 55 well well RB cord-014516-r59usk02 789 56 as as IN cord-014516-r59usk02 789 57 one one CD cord-014516-r59usk02 789 58 - - HYPH cord-014516-r59usk02 789 59 way way NN cord-014516-r59usk02 789 60 ANOVA ANOVA NNP cord-014516-r59usk02 789 61 , , , cord-014516-r59usk02 789 62 t t NN cord-014516-r59usk02 789 63 - - HYPH cord-014516-r59usk02 789 64 test test NN cord-014516-r59usk02 789 65 and and CC cord-014516-r59usk02 789 66 Fisher Fisher NNP cord-014516-r59usk02 789 67 's 's POS cord-014516-r59usk02 789 68 LSD LSD NNP cord-014516-r59usk02 789 69 test test NN cord-014516-r59usk02 789 70 . . . cord-014516-r59usk02 790 1 CRP CRP NNP cord-014516-r59usk02 790 2 and and CC cord-014516-r59usk02 790 3 Alb Alb NNP cord-014516-r59usk02 790 4 were be VBD cord-014516-r59usk02 790 5 by by IN cord-014516-r59usk02 790 6 far far RB cord-014516-r59usk02 790 7 the the DT cord-014516-r59usk02 790 8 APPs app NNS cord-014516-r59usk02 790 9 most most RBS cord-014516-r59usk02 790 10 frequently frequently RB cord-014516-r59usk02 790 11 correlated correlate VBN cord-014516-r59usk02 790 12 with with IN cord-014516-r59usk02 790 13 clinical clinical JJ cord-014516-r59usk02 790 14 and and CC cord-014516-r59usk02 790 15 laboratory laboratory NN cord-014516-r59usk02 790 16 abnormalities abnormality NNS cord-014516-r59usk02 790 17 such such JJ cord-014516-r59usk02 790 18 as as IN cord-014516-r59usk02 790 19 nutritional nutritional JJ cord-014516-r59usk02 790 20 status status NN cord-014516-r59usk02 790 21 , , , cord-014516-r59usk02 790 22 lethargy lethargy NN cord-014516-r59usk02 790 23 and and CC cord-014516-r59usk02 790 24 skin skin NN cord-014516-r59usk02 790 25 ulcers ulcer NNS cord-014516-r59usk02 790 26 ( ( -LRB- cord-014516-r59usk02 790 27 P p NN cord-014516-r59usk02 790 28 < < XX cord-014516-r59usk02 790 29 0,05 0,05 NNP cord-014516-r59usk02 790 30 ) ) -RRB- cord-014516-r59usk02 790 31 , , , cord-014516-r59usk02 790 32 as as RB cord-014516-r59usk02 790 33 well well RB cord-014516-r59usk02 790 34 as as IN cord-014516-r59usk02 790 35 urinary urinary JJ cord-014516-r59usk02 790 36 protein protein NN cord-014516-r59usk02 790 37 to to IN cord-014516-r59usk02 790 38 creatinine creatinine NN cord-014516-r59usk02 790 39 ratio ratio NN cord-014516-r59usk02 790 40 ( ( -LRB- cord-014516-r59usk02 790 41 UPC UPC NNP cord-014516-r59usk02 790 42 ) ) -RRB- cord-014516-r59usk02 790 43 , , , cord-014516-r59usk02 790 44 total total JJ cord-014516-r59usk02 790 45 serum serum NN cord-014516-r59usk02 790 46 protein protein NN cord-014516-r59usk02 790 47 , , , cord-014516-r59usk02 790 48 and and CC cord-014516-r59usk02 790 49 urine urine VB cord-014516-r59usk02 790 50 specific specific JJ cord-014516-r59usk02 790 51 gravity gravity NN cord-014516-r59usk02 790 52 ( ( -LRB- cord-014516-r59usk02 790 53 P p NN cord-014516-r59usk02 790 54 < < XX cord-014516-r59usk02 790 55 0,02 0,02 XX cord-014516-r59usk02 790 56 ) ) -RRB- cord-014516-r59usk02 790 57 . . . cord-014516-r59usk02 791 1 There there EX cord-014516-r59usk02 791 2 were be VBD cord-014516-r59usk02 791 3 limited limited JJ cord-014516-r59usk02 791 4 associations association NNS cord-014516-r59usk02 791 5 between between IN cord-014516-r59usk02 791 6 Hp Hp NNP cord-014516-r59usk02 791 7 , , , cord-014516-r59usk02 791 8 Cp Cp NNP cord-014516-r59usk02 791 9 , , , cord-014516-r59usk02 791 10 SAA SAA NNP cord-014516-r59usk02 791 11 and and CC cord-014516-r59usk02 791 12 clinicopathological clinicopathological NN cord-014516-r59usk02 791 13 parameters parameter NNS cord-014516-r59usk02 791 14 . . . cord-014516-r59usk02 792 1 A a DT cord-014516-r59usk02 792 2 minor minor JJ cord-014516-r59usk02 792 3 linear linear JJ cord-014516-r59usk02 792 4 relationship relationship NN cord-014516-r59usk02 792 5 was be VBD cord-014516-r59usk02 792 6 observed observe VBN cord-014516-r59usk02 792 7 between between IN cord-014516-r59usk02 792 8 CRP CRP NNP cord-014516-r59usk02 792 9 and and CC cord-014516-r59usk02 792 10 clinical clinical JJ cord-014516-r59usk02 792 11 scoring scoring NN cord-014516-r59usk02 792 12 . . . cord-014516-r59usk02 793 1 CRP CRP NNP cord-014516-r59usk02 793 2 and and CC cord-014516-r59usk02 793 3 Alb Alb NNP cord-014516-r59usk02 793 4 were be VBD cord-014516-r59usk02 793 5 also also RB cord-014516-r59usk02 793 6 correlated correlate VBN cord-014516-r59usk02 793 7 with with IN cord-014516-r59usk02 793 8 parasitological parasitological JJ cord-014516-r59usk02 793 9 scoring scoring NN cord-014516-r59usk02 793 10 in in IN cord-014516-r59usk02 793 11 bone bone NN cord-014516-r59usk02 793 12 marrow marrow NN cord-014516-r59usk02 793 13 , , , cord-014516-r59usk02 793 14 but but CC cord-014516-r59usk02 793 15 not not RB cord-014516-r59usk02 793 16 lymph lymph NN cord-014516-r59usk02 793 17 node node NN cord-014516-r59usk02 793 18 cytology cytology NN cord-014516-r59usk02 793 19 ( ( -LRB- cord-014516-r59usk02 793 20 P p NN cord-014516-r59usk02 793 21 < < XX cord-014516-r59usk02 793 22 0.04 0.04 CD cord-014516-r59usk02 793 23 ) ) -RRB- cord-014516-r59usk02 793 24 . . . cord-014516-r59usk02 794 1 Dogs dog NNS cord-014516-r59usk02 794 2 with with IN cord-014516-r59usk02 794 3 Ehrlichia Ehrlichia NNP cord-014516-r59usk02 794 4 titers titer NNS cord-014516-r59usk02 794 5 had have VBD cord-014516-r59usk02 794 6 higher high JJR cord-014516-r59usk02 794 7 CRP CRP NNP cord-014516-r59usk02 794 8 , , , cord-014516-r59usk02 794 9 Cp cp NN cord-014516-r59usk02 794 10 and and CC cord-014516-r59usk02 794 11 lower low JJR cord-014516-r59usk02 794 12 Alb Alb NNP cord-014516-r59usk02 794 13 concentrations concentration NNS cord-014516-r59usk02 794 14 . . . cord-014516-r59usk02 795 1 Finally finally RB cord-014516-r59usk02 795 2 , , , cord-014516-r59usk02 795 3 CRP CRP NNP cord-014516-r59usk02 795 4 concentrations concentration NNS cord-014516-r59usk02 795 5 were be VBD cord-014516-r59usk02 795 6 higher high JJR cord-014516-r59usk02 795 7 in in IN cord-014516-r59usk02 795 8 later later RB cord-014516-r59usk02 795 9 compared compare VBN cord-014516-r59usk02 795 10 to to IN cord-014516-r59usk02 795 11 earlier early JJR cord-014516-r59usk02 795 12 stages stage NNS cord-014516-r59usk02 795 13 of of IN cord-014516-r59usk02 795 14 the the DT cord-014516-r59usk02 795 15 infection infection NN cord-014516-r59usk02 795 16 , , , cord-014516-r59usk02 795 17 as as IN cord-014516-r59usk02 795 18 defined define VBN cord-014516-r59usk02 795 19 by by IN cord-014516-r59usk02 795 20 the the DT cord-014516-r59usk02 795 21 Leishvet Leishvet NNP cord-014516-r59usk02 795 22 criteria criterion NNS cord-014516-r59usk02 795 23 . . . cord-014516-r59usk02 796 1 The the DT cord-014516-r59usk02 796 2 inflammatory inflammatory JJ cord-014516-r59usk02 796 3 component component NN cord-014516-r59usk02 796 4 to to IN cord-014516-r59usk02 796 5 Leishmania Leishmania NNP cord-014516-r59usk02 796 6 infection infection NN cord-014516-r59usk02 796 7 does do VBZ cord-014516-r59usk02 796 8 n't not RB cord-014516-r59usk02 796 9 seem seem VB cord-014516-r59usk02 796 10 to to TO cord-014516-r59usk02 796 11 be be VB cord-014516-r59usk02 796 12 exemplified exemplify VBN cord-014516-r59usk02 796 13 by by IN cord-014516-r59usk02 796 14 the the DT cord-014516-r59usk02 796 15 reaction reaction NN cord-014516-r59usk02 796 16 of of IN cord-014516-r59usk02 796 17 a a DT cord-014516-r59usk02 796 18 particular particular JJ cord-014516-r59usk02 796 19 tissue tissue NN cord-014516-r59usk02 796 20 , , , cord-014516-r59usk02 796 21 with with IN cord-014516-r59usk02 796 22 the the DT cord-014516-r59usk02 796 23 possible possible JJ cord-014516-r59usk02 796 24 exception exception NN cord-014516-r59usk02 796 25 of of IN cord-014516-r59usk02 796 26 glomerulonephritis glomerulonephritis NN cord-014516-r59usk02 796 27 . . . cord-014516-r59usk02 797 1 The the DT cord-014516-r59usk02 797 2 magnitude magnitude NN cord-014516-r59usk02 797 3 of of IN cord-014516-r59usk02 797 4 increase increase NN cord-014516-r59usk02 797 5 in in IN cord-014516-r59usk02 797 6 CRP crp NN cord-014516-r59usk02 797 7 and and CC cord-014516-r59usk02 797 8 decrease decrease NN cord-014516-r59usk02 797 9 in in IN cord-014516-r59usk02 797 10 albumin albumin NN cord-014516-r59usk02 797 11 is be VBZ cord-014516-r59usk02 797 12 correlated correlate VBN cord-014516-r59usk02 797 13 with with IN cord-014516-r59usk02 797 14 clinical clinical JJ cord-014516-r59usk02 797 15 staging staging NN cord-014516-r59usk02 797 16 and and CC cord-014516-r59usk02 797 17 bone bone NN cord-014516-r59usk02 797 18 marrow marrow NN cord-014516-r59usk02 797 19 parasitological parasitological NN cord-014516-r59usk02 797 20 scoring scoring NN cord-014516-r59usk02 797 21 . . . cord-014516-r59usk02 798 1 No no DT cord-014516-r59usk02 798 2 conflicts conflict NNS cord-014516-r59usk02 798 3 of of IN cord-014516-r59usk02 798 4 interest interest NN cord-014516-r59usk02 798 5 reported report VBN cord-014516-r59usk02 798 6 . . . cord-014516-r59usk02 799 1 The the DT cord-014516-r59usk02 799 2 consequences consequence NNS cord-014516-r59usk02 799 3 of of IN cord-014516-r59usk02 799 4 abnormal abnormal JJ cord-014516-r59usk02 799 5 platelet platelet NN cord-014516-r59usk02 799 6 function function NN cord-014516-r59usk02 799 7 in in IN cord-014516-r59usk02 799 8 dogs dog NNS cord-014516-r59usk02 799 9 and and CC cord-014516-r59usk02 799 10 cats cat NNS cord-014516-r59usk02 799 11 can can MD cord-014516-r59usk02 799 12 be be VB cord-014516-r59usk02 799 13 devastating devastating JJ cord-014516-r59usk02 799 14 and and CC cord-014516-r59usk02 799 15 the the DT cord-014516-r59usk02 799 16 use use NN cord-014516-r59usk02 799 17 of of IN cord-014516-r59usk02 799 18 anti anti JJ cord-014516-r59usk02 799 19 - - JJ cord-014516-r59usk02 799 20 thrombotic thrombotic JJ cord-014516-r59usk02 799 21 therapy therapy NN cord-014516-r59usk02 799 22 to to TO cord-014516-r59usk02 799 23 prevent prevent VB cord-014516-r59usk02 799 24 thrombotic thrombotic JJ cord-014516-r59usk02 799 25 events event NNS cord-014516-r59usk02 799 26 is be VBZ cord-014516-r59usk02 799 27 increasingly increasingly RB cord-014516-r59usk02 799 28 common common JJ cord-014516-r59usk02 799 29 . . . cord-014516-r59usk02 800 1 The the DT cord-014516-r59usk02 800 2 ability ability NN cord-014516-r59usk02 800 3 to to TO cord-014516-r59usk02 800 4 measure measure VB cord-014516-r59usk02 800 5 platelet platelet NN cord-014516-r59usk02 800 6 function function NN cord-014516-r59usk02 800 7 and and CC cord-014516-r59usk02 800 8 the the DT cord-014516-r59usk02 800 9 efficacy efficacy NN cord-014516-r59usk02 800 10 of of IN cord-014516-r59usk02 800 11 anti anti JJ cord-014516-r59usk02 800 12 - - JJ cord-014516-r59usk02 800 13 thrombotic thrombotic JJ cord-014516-r59usk02 800 14 therapy therapy NN cord-014516-r59usk02 800 15 is be VBZ cord-014516-r59usk02 800 16 difficult difficult JJ cord-014516-r59usk02 800 17 due due IN cord-014516-r59usk02 800 18 to to IN cord-014516-r59usk02 800 19 limited limited JJ cord-014516-r59usk02 800 20 availability availability NN cord-014516-r59usk02 800 21 of of IN cord-014516-r59usk02 800 22 equipment equipment NN cord-014516-r59usk02 800 23 and and CC cord-014516-r59usk02 800 24 inability inability NN cord-014516-r59usk02 800 25 to to TO cord-014516-r59usk02 800 26 delay delay VB cord-014516-r59usk02 800 27 platelet platelet NN cord-014516-r59usk02 800 28 function function NN cord-014516-r59usk02 800 29 analysis analysis NN cord-014516-r59usk02 800 30 . . . cord-014516-r59usk02 801 1 The the DT cord-014516-r59usk02 801 2 aim aim NN cord-014516-r59usk02 801 3 of of IN cord-014516-r59usk02 801 4 this this DT cord-014516-r59usk02 801 5 study study NN cord-014516-r59usk02 801 6 was be VBD cord-014516-r59usk02 801 7 to to TO cord-014516-r59usk02 801 8 adapt adapt VB cord-014516-r59usk02 801 9 and and CC cord-014516-r59usk02 801 10 validate validate VB cord-014516-r59usk02 801 11 test test NN cord-014516-r59usk02 801 12 procedures procedure NNS cord-014516-r59usk02 801 13 and and CC cord-014516-r59usk02 801 14 protocols protocol NNS cord-014516-r59usk02 801 15 previously previously RB cord-014516-r59usk02 801 16 developed develop VBN cord-014516-r59usk02 801 17 for for IN cord-014516-r59usk02 801 18 humans human NNS cord-014516-r59usk02 801 19 for for IN cord-014516-r59usk02 801 20 use use NN cord-014516-r59usk02 801 21 in in IN cord-014516-r59usk02 801 22 dogs dog NNS cord-014516-r59usk02 801 23 and and CC cord-014516-r59usk02 801 24 cats cat NNS cord-014516-r59usk02 801 25 . . . cord-014516-r59usk02 802 1 Residual residual JJ cord-014516-r59usk02 802 2 samples sample NNS cord-014516-r59usk02 802 3 of of IN cord-014516-r59usk02 802 4 citrate citrate NN cord-014516-r59usk02 802 5 anticoagulated anticoagulated JJ cord-014516-r59usk02 802 6 blood blood NN cord-014516-r59usk02 802 7 were be VBD cord-014516-r59usk02 802 8 used use VBN cord-014516-r59usk02 802 9 from from IN cord-014516-r59usk02 802 10 dogs dog NNS cord-014516-r59usk02 802 11 and and CC cord-014516-r59usk02 802 12 cats cat NNS cord-014516-r59usk02 802 13 presented present VBN cord-014516-r59usk02 802 14 to to IN cord-014516-r59usk02 802 15 a a DT cord-014516-r59usk02 802 16 specialist specialist JJ cord-014516-r59usk02 802 17 referral referral NN cord-014516-r59usk02 802 18 centre centre NN cord-014516-r59usk02 802 19 for for IN cord-014516-r59usk02 802 20 various various JJ cord-014516-r59usk02 802 21 reasons reason NNS cord-014516-r59usk02 802 22 unrelated unrelated JJ cord-014516-r59usk02 802 23 to to IN cord-014516-r59usk02 802 24 clotting clotting NN cord-014516-r59usk02 802 25 abnormalities abnormality NNS cord-014516-r59usk02 802 26 . . . cord-014516-r59usk02 803 1 Initially initially RB cord-014516-r59usk02 803 2 the the DT cord-014516-r59usk02 803 3 blood blood NN cord-014516-r59usk02 803 4 was be VBD cord-014516-r59usk02 803 5 stimulated stimulate VBN cord-014516-r59usk02 803 6 using use VBG cord-014516-r59usk02 803 7 specific specific JJ cord-014516-r59usk02 803 8 combinations combination NNS cord-014516-r59usk02 803 9 of of IN cord-014516-r59usk02 803 10 either either DT cord-014516-r59usk02 803 11 arachidonic arachidonic JJ cord-014516-r59usk02 803 12 acid acid NN cord-014516-r59usk02 803 13 / / SYM cord-014516-r59usk02 803 14 epinephrine epinephrine NN cord-014516-r59usk02 803 15 ( ( -LRB- cord-014516-r59usk02 803 16 AA AA NNP cord-014516-r59usk02 803 17 / / SYM cord-014516-r59usk02 803 18 EPI EPI NNP cord-014516-r59usk02 803 19 ) ) -RRB- cord-014516-r59usk02 803 20 or or CC cord-014516-r59usk02 803 21 ADP ADP NNP cord-014516-r59usk02 803 22 / / SYM cord-014516-r59usk02 803 23 U46619 U46619 NNP cord-014516-r59usk02 803 24 , , , cord-014516-r59usk02 803 25 designed design VBN cord-014516-r59usk02 803 26 to to TO cord-014516-r59usk02 803 27 assess assess VB cord-014516-r59usk02 803 28 the the DT cord-014516-r59usk02 803 29 effects effect NNS cord-014516-r59usk02 803 30 of of IN cord-014516-r59usk02 803 31 the the DT cord-014516-r59usk02 803 32 anti anti JJ cord-014516-r59usk02 803 33 - - JJ cord-014516-r59usk02 803 34 thrombotic thrombotic JJ cord-014516-r59usk02 803 35 agents agent NNS cord-014516-r59usk02 803 36 aspirin aspirin NN cord-014516-r59usk02 803 37 and and CC cord-014516-r59usk02 803 38 clopidogrel clopidogrel NN cord-014516-r59usk02 803 39 respectively respectively RB cord-014516-r59usk02 803 40 . . . cord-014516-r59usk02 804 1 After after IN cord-014516-r59usk02 804 2 5 5 CD cord-014516-r59usk02 804 3 minutes minute NNS cord-014516-r59usk02 804 4 stimulation stimulation NN cord-014516-r59usk02 804 5 , , , cord-014516-r59usk02 804 6 the the DT cord-014516-r59usk02 804 7 blood blood NN cord-014516-r59usk02 804 8 samples sample NNS cord-014516-r59usk02 804 9 were be VBD cord-014516-r59usk02 804 10 fixed fix VBN cord-014516-r59usk02 804 11 using use VBG cord-014516-r59usk02 804 12 a a DT cord-014516-r59usk02 804 13 patented patent VBN cord-014516-r59usk02 804 14 platelet platelet NN cord-014516-r59usk02 804 15 fixative fixative NN cord-014516-r59usk02 804 16 solution solution NN cord-014516-r59usk02 804 17 developed develop VBN cord-014516-r59usk02 804 18 for for IN cord-014516-r59usk02 804 19 human human JJ cord-014516-r59usk02 804 20 platelets platelet NNS cord-014516-r59usk02 804 21 , , , cord-014516-r59usk02 804 22 which which WDT cord-014516-r59usk02 804 23 allows allow VBZ cord-014516-r59usk02 804 24 the the DT cord-014516-r59usk02 804 25 delayed delay VBN cord-014516-r59usk02 804 26 analysis analysis NN cord-014516-r59usk02 804 27 of of IN cord-014516-r59usk02 804 28 P p NN cord-014516-r59usk02 804 29 - - , cord-014516-r59usk02 804 30 selectin selectin NNP cord-014516-r59usk02 804 31 an an DT cord-014516-r59usk02 804 32 established establish VBN cord-014516-r59usk02 804 33 marker marker NN cord-014516-r59usk02 804 34 of of IN cord-014516-r59usk02 804 35 platelet platelet NN cord-014516-r59usk02 804 36 activation activation NN cord-014516-r59usk02 804 37 . . . cord-014516-r59usk02 805 1 All all DT cord-014516-r59usk02 805 2 analysis analysis NN cord-014516-r59usk02 805 3 was be VBD cord-014516-r59usk02 805 4 performed perform VBN cord-014516-r59usk02 805 5 by by IN cord-014516-r59usk02 805 6 flow flow NN cord-014516-r59usk02 805 7 cytometry cytometry NN cord-014516-r59usk02 805 8 . . . cord-014516-r59usk02 806 1 In in IN cord-014516-r59usk02 806 2 order order NN cord-014516-r59usk02 806 3 to to TO cord-014516-r59usk02 806 4 do do VB cord-014516-r59usk02 806 5 this this DT cord-014516-r59usk02 806 6 , , , cord-014516-r59usk02 806 7 specific specific JJ cord-014516-r59usk02 806 8 antibodies antibody NNS cord-014516-r59usk02 806 9 were be VBD cord-014516-r59usk02 806 10 selected select VBN cord-014516-r59usk02 806 11 for for IN cord-014516-r59usk02 806 12 the the DT cord-014516-r59usk02 806 13 recognition recognition NN cord-014516-r59usk02 806 14 of of IN cord-014516-r59usk02 806 15 both both CC cord-014516-r59usk02 806 16 canine canine JJ cord-014516-r59usk02 806 17 and and CC cord-014516-r59usk02 806 18 feline feline JJ cord-014516-r59usk02 806 19 platelets platelet NNS cord-014516-r59usk02 806 20 . . . cord-014516-r59usk02 807 1 CD61 CD61 NNP cord-014516-r59usk02 807 2 was be VBD cord-014516-r59usk02 807 3 used use VBN cord-014516-r59usk02 807 4 as as IN cord-014516-r59usk02 807 5 a a DT cord-014516-r59usk02 807 6 platelet platelet NN cord-014516-r59usk02 807 7 identifier identifier NN cord-014516-r59usk02 807 8 antibody antibody NN cord-014516-r59usk02 807 9 while while IN cord-014516-r59usk02 807 10 appropriate appropriate JJ cord-014516-r59usk02 807 11 CD62P cd62p NN cord-014516-r59usk02 808 1 ( ( -LRB- cord-014516-r59usk02 808 2 P p NN cord-014516-r59usk02 808 3 - - HYPH cord-014516-r59usk02 808 4 selectin selectin NNP cord-014516-r59usk02 808 5 ) ) -RRB- cord-014516-r59usk02 809 1 antibodies antibody NNS cord-014516-r59usk02 809 2 for for IN cord-014516-r59usk02 809 3 each each DT cord-014516-r59usk02 809 4 species specie NNS cord-014516-r59usk02 809 5 were be VBD cord-014516-r59usk02 809 6 chosen choose VBN cord-014516-r59usk02 809 7 . . . cord-014516-r59usk02 810 1 Fixed fix VBN cord-014516-r59usk02 810 2 samples sample NNS cord-014516-r59usk02 810 3 were be VBD cord-014516-r59usk02 810 4 repeatedly repeatedly RB cord-014516-r59usk02 810 5 analysed analyse VBN cord-014516-r59usk02 810 6 at at IN cord-014516-r59usk02 810 7 time time NN cord-014516-r59usk02 810 8 points point NNS cord-014516-r59usk02 810 9 between between IN cord-014516-r59usk02 810 10 0 0 CD cord-014516-r59usk02 810 11 to to TO cord-014516-r59usk02 810 12 35 35 CD cord-014516-r59usk02 810 13 days day NNS cord-014516-r59usk02 810 14 following follow VBG cord-014516-r59usk02 810 15 fixation fixation NN cord-014516-r59usk02 810 16 to to TO cord-014516-r59usk02 810 17 establish establish VB cord-014516-r59usk02 810 18 the the DT cord-014516-r59usk02 810 19 stability stability NN cord-014516-r59usk02 810 20 of of IN cord-014516-r59usk02 810 21 the the DT cord-014516-r59usk02 810 22 fixed fix VBN cord-014516-r59usk02 810 23 samples sample NNS cord-014516-r59usk02 810 24 . . . cord-014516-r59usk02 811 1 Thirteen thirteen CD cord-014516-r59usk02 811 2 dogs dog NNS cord-014516-r59usk02 811 3 and and CC cord-014516-r59usk02 811 4 three three CD cord-014516-r59usk02 811 5 cats cat NNS cord-014516-r59usk02 811 6 were be VBD cord-014516-r59usk02 811 7 analysed analyse VBN cord-014516-r59usk02 811 8 . . . cord-014516-r59usk02 812 1 High high JJ cord-014516-r59usk02 812 2 P p NN cord-014516-r59usk02 812 3 - - HYPH cord-014516-r59usk02 812 4 selectin selectin JJ cord-014516-r59usk02 812 5 expression expression NN cord-014516-r59usk02 812 6 was be VBD cord-014516-r59usk02 812 7 detected detect VBN cord-014516-r59usk02 812 8 following follow VBG cord-014516-r59usk02 812 9 stimulation stimulation NN cord-014516-r59usk02 812 10 with with IN cord-014516-r59usk02 812 11 AA AA NNP cord-014516-r59usk02 812 12 / / SYM cord-014516-r59usk02 812 13 EPI EPI NNP cord-014516-r59usk02 812 14 and and CC cord-014516-r59usk02 812 15 ADP ADP NNP cord-014516-r59usk02 812 16 / / SYM cord-014516-r59usk02 812 17 U46619 U46619 NNP cord-014516-r59usk02 812 18 in in IN cord-014516-r59usk02 812 19 both both DT cord-014516-r59usk02 812 20 dogs dog NNS cord-014516-r59usk02 812 21 and and CC cord-014516-r59usk02 812 22 cats cat NNS cord-014516-r59usk02 812 23 following follow VBG cord-014516-r59usk02 812 24 fixation fixation NN cord-014516-r59usk02 812 25 . . . cord-014516-r59usk02 813 1 This this DT cord-014516-r59usk02 813 2 was be VBD cord-014516-r59usk02 813 3 significantly significantly RB cord-014516-r59usk02 813 4 different different JJ cord-014516-r59usk02 813 5 to to IN cord-014516-r59usk02 813 6 unstimulated unstimulated JJ cord-014516-r59usk02 813 7 blood blood NN cord-014516-r59usk02 813 8 ( ( -LRB- cord-014516-r59usk02 813 9 p p NN cord-014516-r59usk02 813 10 < < XX cord-014516-r59usk02 813 11 0.0001 0.0001 CD cord-014516-r59usk02 813 12 ) ) -RRB- cord-014516-r59usk02 813 13 . . . cord-014516-r59usk02 814 1 There there EX cord-014516-r59usk02 814 2 was be VBD cord-014516-r59usk02 814 3 no no DT cord-014516-r59usk02 814 4 significant significant JJ cord-014516-r59usk02 814 5 difference difference NN cord-014516-r59usk02 814 6 in in IN cord-014516-r59usk02 814 7 detectable detectable JJ cord-014516-r59usk02 814 8 Pselectin Pselectin NNP cord-014516-r59usk02 814 9 expression expression NN cord-014516-r59usk02 814 10 following follow VBG cord-014516-r59usk02 814 11 storage storage NN cord-014516-r59usk02 814 12 of of IN cord-014516-r59usk02 814 13 the the DT cord-014516-r59usk02 814 14 fixed fix VBN cord-014516-r59usk02 814 15 samples sample NNS cord-014516-r59usk02 814 16 at at IN cord-014516-r59usk02 814 17 any any DT cord-014516-r59usk02 814 18 time time NN cord-014516-r59usk02 814 19 - - HYPH cord-014516-r59usk02 814 20 point point NN cord-014516-r59usk02 814 21 up up IN cord-014516-r59usk02 814 22 to to TO cord-014516-r59usk02 814 23 35 35 CD cord-014516-r59usk02 814 24 days day NNS cord-014516-r59usk02 814 25 . . . cord-014516-r59usk02 815 1 This this DT cord-014516-r59usk02 815 2 confirmed confirm VBD cord-014516-r59usk02 815 3 the the DT cord-014516-r59usk02 815 4 fixative fixative NN cord-014516-r59usk02 815 5 was be VBD cord-014516-r59usk02 815 6 suitable suitable JJ cord-014516-r59usk02 815 7 as as IN cord-014516-r59usk02 815 8 a a DT cord-014516-r59usk02 815 9 preservative preservative NN cord-014516-r59usk02 815 10 of of IN cord-014516-r59usk02 815 11 canine canine JJ cord-014516-r59usk02 815 12 and and CC cord-014516-r59usk02 815 13 feline feline JJ cord-014516-r59usk02 815 14 platelets platelet NNS cord-014516-r59usk02 815 15 . . . cord-014516-r59usk02 816 1 A a DT cord-014516-r59usk02 816 2 limited limited JJ cord-014516-r59usk02 816 3 number number NN cord-014516-r59usk02 816 4 of of IN cord-014516-r59usk02 816 5 dogs dog NNS cord-014516-r59usk02 816 6 were be VBD cord-014516-r59usk02 816 7 evaluated evaluate VBN cord-014516-r59usk02 816 8 whilst whilst IN cord-014516-r59usk02 816 9 receiving receive VBG cord-014516-r59usk02 816 10 antithrombotic antithrombotic JJ cord-014516-r59usk02 816 11 medication medication NN cord-014516-r59usk02 816 12 . . . cord-014516-r59usk02 817 1 There there EX cord-014516-r59usk02 817 2 was be VBD cord-014516-r59usk02 817 3 a a DT cord-014516-r59usk02 817 4 significant significant JJ cord-014516-r59usk02 817 5 difference difference NN cord-014516-r59usk02 817 6 in in IN cord-014516-r59usk02 817 7 the the DT cord-014516-r59usk02 817 8 activation activation NN cord-014516-r59usk02 817 9 of of IN cord-014516-r59usk02 817 10 platelets platelet NNS cord-014516-r59usk02 817 11 in in IN cord-014516-r59usk02 817 12 the the DT cord-014516-r59usk02 817 13 dogs dog NNS cord-014516-r59usk02 817 14 treated treat VBN cord-014516-r59usk02 817 15 with with IN cord-014516-r59usk02 817 16 either either CC cord-014516-r59usk02 817 17 aspirin aspirin NN cord-014516-r59usk02 817 18 ( ( -LRB- cord-014516-r59usk02 817 19 p p NN cord-014516-r59usk02 817 20 < < XX cord-014516-r59usk02 817 21 0.03 0.03 CD cord-014516-r59usk02 817 22 ) ) -RRB- cord-014516-r59usk02 817 23 or or CC cord-014516-r59usk02 817 24 clopidogrel clopidogrel NN cord-014516-r59usk02 817 25 ( ( -LRB- cord-014516-r59usk02 817 26 p p NN cord-014516-r59usk02 817 27 < < XX cord-014516-r59usk02 817 28 0.004 0.004 CD cord-014516-r59usk02 817 29 ) ) -RRB- cord-014516-r59usk02 817 30 compared compare VBN cord-014516-r59usk02 817 31 with with IN cord-014516-r59usk02 817 32 untreated untreated JJ cord-014516-r59usk02 817 33 dogs dog NNS cord-014516-r59usk02 817 34 following follow VBG cord-014516-r59usk02 817 35 stimulation stimulation NN cord-014516-r59usk02 817 36 with with IN cord-014516-r59usk02 817 37 AA AA NNP cord-014516-r59usk02 817 38 / / SYM cord-014516-r59usk02 817 39 EPI EPI NNP cord-014516-r59usk02 817 40 ( ( -LRB- cord-014516-r59usk02 817 41 aspirin aspirin NN cord-014516-r59usk02 817 42 group group NN cord-014516-r59usk02 817 43 ) ) -RRB- cord-014516-r59usk02 817 44 or or CC cord-014516-r59usk02 817 45 ADP/ adp/ JJ cord-014516-r59usk02 817 46 U46619 U46619 NNP cord-014516-r59usk02 817 47 ( ( -LRB- cord-014516-r59usk02 817 48 clopidogrel clopidogrel NNP cord-014516-r59usk02 817 49 group group NN cord-014516-r59usk02 817 50 ) ) -RRB- cord-014516-r59usk02 817 51 . . . cord-014516-r59usk02 818 1 Our -PRON- PRP$ cord-014516-r59usk02 818 2 results result NNS cord-014516-r59usk02 818 3 show show VBP cord-014516-r59usk02 818 4 that that IN cord-014516-r59usk02 818 5 fixation fixation NN cord-014516-r59usk02 818 6 and and CC cord-014516-r59usk02 818 7 delayed delay VBN cord-014516-r59usk02 818 8 analysis analysis NN cord-014516-r59usk02 818 9 of of IN cord-014516-r59usk02 818 10 platelet platelet NN cord-014516-r59usk02 818 11 function function NN cord-014516-r59usk02 818 12 in in IN cord-014516-r59usk02 818 13 dogs dog NNS cord-014516-r59usk02 818 14 and and CC cord-014516-r59usk02 818 15 cats cat NNS cord-014516-r59usk02 818 16 is be VBZ cord-014516-r59usk02 818 17 possible possible JJ cord-014516-r59usk02 818 18 for for IN cord-014516-r59usk02 818 19 up up IN cord-014516-r59usk02 818 20 to to TO cord-014516-r59usk02 818 21 35 35 CD cord-014516-r59usk02 818 22 days day NNS cord-014516-r59usk02 818 23 . . . cord-014516-r59usk02 819 1 This this DT cord-014516-r59usk02 819 2 demonstrates demonstrate VBZ cord-014516-r59usk02 819 3 an an DT cord-014516-r59usk02 819 4 exciting exciting JJ cord-014516-r59usk02 819 5 opportunity opportunity NN cord-014516-r59usk02 819 6 to to TO cord-014516-r59usk02 819 7 analyse analyse VB cord-014516-r59usk02 819 8 platelet platelet NN cord-014516-r59usk02 819 9 function function NN cord-014516-r59usk02 819 10 remotely remotely RB cord-014516-r59usk02 819 11 and and CC cord-014516-r59usk02 819 12 to to TO cord-014516-r59usk02 819 13 determine determine VB cord-014516-r59usk02 819 14 the the DT cord-014516-r59usk02 819 15 efficacy efficacy NN cord-014516-r59usk02 819 16 of of IN cord-014516-r59usk02 819 17 thromboprophylaxis thromboprophylaxis NN cord-014516-r59usk02 819 18 in in IN cord-014516-r59usk02 819 19 animals animal NNS cord-014516-r59usk02 819 20 presenting present VBG cord-014516-r59usk02 819 21 to to IN cord-014516-r59usk02 819 22 clinics clinic NNS cord-014516-r59usk02 819 23 that that WDT cord-014516-r59usk02 819 24 do do VBP cord-014516-r59usk02 819 25 not not RB cord-014516-r59usk02 819 26 have have VB cord-014516-r59usk02 819 27 on on IN cord-014516-r59usk02 819 28 - - HYPH cord-014516-r59usk02 819 29 site site NN cord-014516-r59usk02 819 30 platelet platelet NN cord-014516-r59usk02 819 31 analysers analyser NNS cord-014516-r59usk02 819 32 . . . cord-014516-r59usk02 820 1 No no DT cord-014516-r59usk02 820 2 conflicts conflict NNS cord-014516-r59usk02 820 3 of of IN cord-014516-r59usk02 820 4 interest interest NN cord-014516-r59usk02 820 5 reported report VBN cord-014516-r59usk02 820 6 . . . cord-014516-r59usk02 821 1 Several several JJ cord-014516-r59usk02 821 2 authors author NNS cord-014516-r59usk02 821 3 consider consider VBP cord-014516-r59usk02 821 4 thyroid thyroid JJ cord-014516-r59usk02 821 5 hormone hormone NN cord-014516-r59usk02 821 6 supplementation supplementation NN cord-014516-r59usk02 821 7 as as IN cord-014516-r59usk02 821 8 a a DT cord-014516-r59usk02 821 9 valid valid JJ cord-014516-r59usk02 821 10 initial initial JJ cord-014516-r59usk02 821 11 treatment treatment NN cord-014516-r59usk02 821 12 option option NN cord-014516-r59usk02 821 13 for for IN cord-014516-r59usk02 821 14 dogs dog NNS cord-014516-r59usk02 821 15 with with IN cord-014516-r59usk02 821 16 aggression aggression NN cord-014516-r59usk02 821 17 related relate VBN cord-014516-r59usk02 821 18 problems problem NNS cord-014516-r59usk02 821 19 . . . cord-014516-r59usk02 822 1 Indeed indeed RB cord-014516-r59usk02 822 2 , , , cord-014516-r59usk02 822 3 mood mood NN cord-014516-r59usk02 822 4 and and CC cord-014516-r59usk02 822 5 behaviour behaviour NN cord-014516-r59usk02 822 6 modulating modulate VBG cord-014516-r59usk02 822 7 properties property NNS cord-014516-r59usk02 822 8 of of IN cord-014516-r59usk02 822 9 thyroid thyroid JJ cord-014516-r59usk02 822 10 hormones hormone NNS cord-014516-r59usk02 822 11 may may MD cord-014516-r59usk02 822 12 , , , cord-014516-r59usk02 822 13 in in IN cord-014516-r59usk02 822 14 part part NN cord-014516-r59usk02 822 15 , , , cord-014516-r59usk02 822 16 be be VB cord-014516-r59usk02 822 17 mediated mediate VBN cord-014516-r59usk02 822 18 through through IN cord-014516-r59usk02 822 19 the the DT cord-014516-r59usk02 822 20 interaction interaction NN cord-014516-r59usk02 822 21 of of IN cord-014516-r59usk02 822 22 thyroid thyroid JJ cord-014516-r59usk02 822 23 hormones hormone NNS cord-014516-r59usk02 822 24 with with IN cord-014516-r59usk02 822 25 neurohormones neurohormone NNS cord-014516-r59usk02 822 26 such such JJ cord-014516-r59usk02 822 27 as as IN cord-014516-r59usk02 822 28 serotonin serotonin NN cord-014516-r59usk02 822 29 and and CC cord-014516-r59usk02 822 30 prolactin prolactin NN cord-014516-r59usk02 822 31 . . . cord-014516-r59usk02 823 1 At at IN cord-014516-r59usk02 823 2 present present JJ cord-014516-r59usk02 823 3 , , , cord-014516-r59usk02 823 4 prospective prospective JJ cord-014516-r59usk02 823 5 trials trial NNS cord-014516-r59usk02 823 6 evaluating evaluate VBG cord-014516-r59usk02 823 7 neurohormonal neurohormonal JJ cord-014516-r59usk02 823 8 status status NN cord-014516-r59usk02 823 9 or or CC cord-014516-r59usk02 823 10 behaviour behaviour NN cord-014516-r59usk02 823 11 in in IN cord-014516-r59usk02 823 12 hypothyroid hypothyroid JJ cord-014516-r59usk02 823 13 dogs dog NNS cord-014516-r59usk02 823 14 before before RB cord-014516-r59usk02 823 15 and and CC cord-014516-r59usk02 823 16 after after IN cord-014516-r59usk02 823 17 thyroid thyroid NN cord-014516-r59usk02 823 18 supplementation supplementation NN cord-014516-r59usk02 823 19 are be VBP cord-014516-r59usk02 823 20 lacking lack VBG cord-014516-r59usk02 823 21 . . . cord-014516-r59usk02 824 1 Therefore therefore RB cord-014516-r59usk02 824 2 , , , cord-014516-r59usk02 824 3 the the DT cord-014516-r59usk02 824 4 aims aim NNS cord-014516-r59usk02 824 5 of of IN cord-014516-r59usk02 824 6 this this DT cord-014516-r59usk02 824 7 study study NN cord-014516-r59usk02 824 8 were be VBD cord-014516-r59usk02 824 9 to to TO cord-014516-r59usk02 824 10 assess assess VB cord-014516-r59usk02 824 11 behaviour behaviour NN cord-014516-r59usk02 824 12 and and CC cord-014516-r59usk02 824 13 measure measure VB cord-014516-r59usk02 824 14 serum serum NN cord-014516-r59usk02 824 15 serotonin serotonin NN cord-014516-r59usk02 824 16 and and CC cord-014516-r59usk02 824 17 prolactin prolactin NN cord-014516-r59usk02 824 18 concentrations concentration NNS cord-014516-r59usk02 824 19 in in IN cord-014516-r59usk02 824 20 dogs dog NNS cord-014516-r59usk02 824 21 with with IN cord-014516-r59usk02 824 22 spontaneous spontaneous JJ cord-014516-r59usk02 824 23 hypothyroidism hypothyroidism NN cord-014516-r59usk02 824 24 before before RB cord-014516-r59usk02 824 25 and and CC cord-014516-r59usk02 824 26 after after IN cord-014516-r59usk02 824 27 treatment treatment NN cord-014516-r59usk02 824 28 . . . cord-014516-r59usk02 825 1 Twenty twenty CD cord-014516-r59usk02 825 2 three three CD cord-014516-r59usk02 825 3 client client NN cord-014516-r59usk02 825 4 - - HYPH cord-014516-r59usk02 825 5 owned own VBN cord-014516-r59usk02 825 6 dogs dog NNS cord-014516-r59usk02 825 7 diagnosed diagnose VBN cord-014516-r59usk02 825 8 with with IN cord-014516-r59usk02 825 9 spontaneous spontaneous JJ cord-014516-r59usk02 825 10 primary primary JJ cord-014516-r59usk02 825 11 hypothyroidism hypothyroidism NN cord-014516-r59usk02 825 12 were be VBD cord-014516-r59usk02 825 13 prospectively prospectively RB cord-014516-r59usk02 825 14 included include VBN cord-014516-r59usk02 825 15 in in IN cord-014516-r59usk02 825 16 our -PRON- PRP$ cord-014516-r59usk02 825 17 study study NN cord-014516-r59usk02 825 18 . . . cord-014516-r59usk02 826 1 After after IN cord-014516-r59usk02 826 2 diagnosis diagnosis NN cord-014516-r59usk02 826 3 all all DT cord-014516-r59usk02 826 4 dogs dog NNS cord-014516-r59usk02 826 5 were be VBD cord-014516-r59usk02 826 6 treated treat VBN cord-014516-r59usk02 826 7 with with IN cord-014516-r59usk02 826 8 levothyroxine levothyroxine NN cord-014516-r59usk02 826 9 ( ( -LRB- cord-014516-r59usk02 826 10 10 10 CD cord-014516-r59usk02 826 11 micrograms microgram NNS cord-014516-r59usk02 826 12 / / SYM cord-014516-r59usk02 826 13 kg kg NN cord-014516-r59usk02 826 14 BID BID NNP cord-014516-r59usk02 826 15 ) ) -RRB- cord-014516-r59usk02 826 16 . . . cord-014516-r59usk02 827 1 Behaviour behaviour NN cord-014516-r59usk02 827 2 of of IN cord-014516-r59usk02 827 3 dogs dog NNS cord-014516-r59usk02 827 4 was be VBD cord-014516-r59usk02 827 5 screened screen VBN cord-014516-r59usk02 827 6 at at IN cord-014516-r59usk02 827 7 initial initial JJ cord-014516-r59usk02 827 8 presentation presentation NN cord-014516-r59usk02 827 9 , , , cord-014516-r59usk02 827 10 at at IN cord-014516-r59usk02 827 11 6 6 CD cord-014516-r59usk02 827 12 weeks week NNS cord-014516-r59usk02 827 13 and and CC cord-014516-r59usk02 827 14 6 6 CD cord-014516-r59usk02 827 15 months month NNS cord-014516-r59usk02 827 16 after after IN cord-014516-r59usk02 827 17 initiation initiation NN cord-014516-r59usk02 827 18 of of IN cord-014516-r59usk02 827 19 therapy therapy NN cord-014516-r59usk02 827 20 . . . cord-014516-r59usk02 828 1 Owners owner NNS cord-014516-r59usk02 828 2 had have VBD cord-014516-r59usk02 828 3 to to TO cord-014516-r59usk02 828 4 fill fill VB cord-014516-r59usk02 828 5 in in RP cord-014516-r59usk02 828 6 a a DT cord-014516-r59usk02 828 7 hard hard JJ cord-014516-r59usk02 828 8 copy copy NN cord-014516-r59usk02 828 9 of of IN cord-014516-r59usk02 828 10 the the DT cord-014516-r59usk02 828 11 standardized standardized JJ cord-014516-r59usk02 828 12 Canine Canine NNP cord-014516-r59usk02 828 13 Behavioural Behavioural NNP cord-014516-r59usk02 828 14 Assessment Assessment NNP cord-014516-r59usk02 828 15 and and CC cord-014516-r59usk02 828 16 Research Research NNP cord-014516-r59usk02 828 17 Questionnaire Questionnaire NNP cord-014516-r59usk02 828 18 ( ( -LRB- cord-014516-r59usk02 828 19 C C NNP cord-014516-r59usk02 828 20 - - HYPH cord-014516-r59usk02 828 21 BARQ BARQ NNP cord-014516-r59usk02 828 22 ) ) -RRB- cord-014516-r59usk02 828 23 consisting consist VBG cord-014516-r59usk02 828 24 of of IN cord-014516-r59usk02 828 25 101 101 CD cord-014516-r59usk02 828 26 scored score VBN cord-014516-r59usk02 828 27 questions question NNS cord-014516-r59usk02 828 28 evaluating evaluate VBG cord-014516-r59usk02 828 29 seven seven CD cord-014516-r59usk02 828 30 behavioural behavioural JJ cord-014516-r59usk02 828 31 categories category NNS cord-014516-r59usk02 828 32 . . . cord-014516-r59usk02 829 1 The the DT cord-014516-r59usk02 829 2 average average JJ cord-014516-r59usk02 829 3 score score NN cord-014516-r59usk02 829 4 on on IN cord-014516-r59usk02 829 5 all all DT cord-014516-r59usk02 829 6 questions question NNS cord-014516-r59usk02 829 7 was be VBD cord-014516-r59usk02 829 8 calculated calculate VBN cord-014516-r59usk02 829 9 for for IN cord-014516-r59usk02 829 10 each each DT cord-014516-r59usk02 829 11 dog dog NN cord-014516-r59usk02 829 12 at at IN cord-014516-r59usk02 829 13 each each DT cord-014516-r59usk02 829 14 of of IN cord-014516-r59usk02 829 15 the the DT cord-014516-r59usk02 829 16 three three CD cord-014516-r59usk02 829 17 time time NN cord-014516-r59usk02 829 18 periods period NNS cord-014516-r59usk02 829 19 and and CC cord-014516-r59usk02 829 20 a a DT cord-014516-r59usk02 829 21 paired paired JJ cord-014516-r59usk02 829 22 t t NN cord-014516-r59usk02 829 23 - - HYPH cord-014516-r59usk02 829 24 test test NN cord-014516-r59usk02 829 25 was be VBD cord-014516-r59usk02 829 26 used use VBN cord-014516-r59usk02 829 27 for for IN cord-014516-r59usk02 829 28 comparison comparison NN cord-014516-r59usk02 829 29 . . . cord-014516-r59usk02 830 1 Serum serum NN cord-014516-r59usk02 830 2 serotonin serotonin NN cord-014516-r59usk02 830 3 and and CC cord-014516-r59usk02 830 4 prolactin prolactin NN cord-014516-r59usk02 830 5 concentrations concentration NNS cord-014516-r59usk02 830 6 were be VBD cord-014516-r59usk02 830 7 evaluated evaluate VBN cord-014516-r59usk02 830 8 at at IN cord-014516-r59usk02 830 9 each each DT cord-014516-r59usk02 830 10 time time NN cord-014516-r59usk02 830 11 period period NN cord-014516-r59usk02 830 12 using use VBG cord-014516-r59usk02 830 13 a a DT cord-014516-r59usk02 830 14 commercially commercially RB cord-014516-r59usk02 830 15 validated validate VBN cord-014516-r59usk02 830 16 ELISA ELISA NNP cord-014516-r59usk02 830 17 kit kit NN cord-014516-r59usk02 830 18 and and CC cord-014516-r59usk02 830 19 heterologous heterologous NNP cord-014516-r59usk02 830 20 RIA RIA NNP cord-014516-r59usk02 830 21 , , , cord-014516-r59usk02 830 22 respectively respectively RB cord-014516-r59usk02 830 23 . . . cord-014516-r59usk02 831 1 Results result NNS cord-014516-r59usk02 831 2 of of IN cord-014516-r59usk02 831 3 the the DT cord-014516-r59usk02 831 4 C C NNP cord-014516-r59usk02 831 5 - - HYPH cord-014516-r59usk02 831 6 BARQ BARQ NNP cord-014516-r59usk02 831 7 after after IN cord-014516-r59usk02 831 8 six six CD cord-014516-r59usk02 831 9 weeks week NNS cord-014516-r59usk02 831 10 of of IN cord-014516-r59usk02 831 11 thyroid thyroid JJ cord-014516-r59usk02 831 12 hormone hormone NN cord-014516-r59usk02 831 13 supplementation supplementation NN cord-014516-r59usk02 831 14 when when WRB cord-014516-r59usk02 831 15 compared compare VBN cord-014516-r59usk02 831 16 with with IN cord-014516-r59usk02 831 17 the the DT cord-014516-r59usk02 831 18 time time NN cord-014516-r59usk02 831 19 zero zero CD cord-014516-r59usk02 831 20 demonstrated demonstrate VBD cord-014516-r59usk02 831 21 a a DT cord-014516-r59usk02 831 22 significant significant JJ cord-014516-r59usk02 831 23 increase increase NN cord-014516-r59usk02 831 24 ( ( -LRB- cord-014516-r59usk02 831 25 P p NN cord-014516-r59usk02 831 26 < < XX cord-014516-r59usk02 831 27 0.05 0.05 CD cord-014516-r59usk02 831 28 ) ) -RRB- cord-014516-r59usk02 831 29 in in IN cord-014516-r59usk02 831 30 excitability excitability NN cord-014516-r59usk02 831 31 , , , cord-014516-r59usk02 831 32 activity activity NN cord-014516-r59usk02 831 33 and and CC cord-014516-r59usk02 831 34 aggression aggression NN cord-014516-r59usk02 831 35 , , , cord-014516-r59usk02 831 36 which which WDT cord-014516-r59usk02 831 37 most most RBS cord-014516-r59usk02 831 38 likely likely RB cord-014516-r59usk02 831 39 became become VBD cord-014516-r59usk02 831 40 unmasked unmasked JJ cord-014516-r59usk02 831 41 owing owe VBG cord-014516-r59usk02 831 42 to to IN cord-014516-r59usk02 831 43 improved improve VBN cord-014516-r59usk02 831 44 overall overall JJ cord-014516-r59usk02 831 45 activity activity NN cord-014516-r59usk02 831 46 of of IN cord-014516-r59usk02 831 47 dogs dog NNS cord-014516-r59usk02 831 48 . . . cord-014516-r59usk02 832 1 Conversely conversely RB cord-014516-r59usk02 832 2 , , , cord-014516-r59usk02 832 3 at at IN cord-014516-r59usk02 832 4 six six CD cord-014516-r59usk02 832 5 months month NNS cord-014516-r59usk02 832 6 period period NN cord-014516-r59usk02 832 7 when when WRB cord-014516-r59usk02 832 8 compared compare VBN cord-014516-r59usk02 832 9 with with IN cord-014516-r59usk02 832 10 the the DT cord-014516-r59usk02 832 11 time time NN cord-014516-r59usk02 832 12 zero zero CD cord-014516-r59usk02 832 13 no no DT cord-014516-r59usk02 832 14 significant significant JJ cord-014516-r59usk02 832 15 changes change NNS cord-014516-r59usk02 832 16 in in IN cord-014516-r59usk02 832 17 any any DT cord-014516-r59usk02 832 18 of of IN cord-014516-r59usk02 832 19 the the DT cord-014516-r59usk02 832 20 behavioural behavioural JJ cord-014516-r59usk02 832 21 symptoms symptom NNS cord-014516-r59usk02 832 22 were be VBD cord-014516-r59usk02 832 23 observed observe VBN cord-014516-r59usk02 832 24 . . . cord-014516-r59usk02 833 1 Serum serum NN cord-014516-r59usk02 833 2 serotonin serotonin NN cord-014516-r59usk02 833 3 was be VBD cord-014516-r59usk02 833 4 measured measure VBN cord-014516-r59usk02 833 5 in in IN cord-014516-r59usk02 833 6 18/23 18/23 CD cord-014516-r59usk02 833 7 dogs dog NNS cord-014516-r59usk02 833 8 colorimetrically colorimetrically RB cord-014516-r59usk02 833 9 at at IN cord-014516-r59usk02 833 10 450 450 CD cord-014516-r59usk02 833 11 nm nm NN cord-014516-r59usk02 833 12 . . . cord-014516-r59usk02 834 1 At at IN cord-014516-r59usk02 834 2 time time NN cord-014516-r59usk02 834 3 zero zero CD cord-014516-r59usk02 834 4 , , , cord-014516-r59usk02 834 5 6 6 CD cord-014516-r59usk02 834 6 weeks week NNS cord-014516-r59usk02 834 7 and and CC cord-014516-r59usk02 834 8 6 6 CD cord-014516-r59usk02 834 9 months month NNS cord-014516-r59usk02 835 1 serum serum NNP cord-014516-r59usk02 835 2 serotonine serotonine NNP cord-014516-r59usk02 835 3 was be VBD cord-014516-r59usk02 835 4 0.135 0.135 CD cord-014516-r59usk02 836 1 ( ( -LRB- cord-014516-r59usk02 836 2 range range NN cord-014516-r59usk02 836 3 , , , cord-014516-r59usk02 836 4 0.075 0.075 CD cord-014516-r59usk02 836 5 - - SYM cord-014516-r59usk02 836 6 0.337 0.337 CD cord-014516-r59usk02 836 7 ) ) -RRB- cord-014516-r59usk02 836 8 , , , cord-014516-r59usk02 836 9 0.141 0.141 CD cord-014516-r59usk02 836 10 ( ( -LRB- cord-014516-r59usk02 836 11 range range NN cord-014516-r59usk02 836 12 , , , cord-014516-r59usk02 836 13 0,071 0,071 CD cord-014516-r59usk02 836 14 - - SYM cord-014516-r59usk02 836 15 0.392 0.392 CD cord-014516-r59usk02 836 16 ) ) -RRB- cord-014516-r59usk02 836 17 and and CC cord-014516-r59usk02 836 18 0.149 0.149 CD cord-014516-r59usk02 837 1 ( ( -LRB- cord-014516-r59usk02 837 2 range range NN cord-014516-r59usk02 837 3 , , , cord-014516-r59usk02 837 4 0.086 0.086 CD cord-014516-r59usk02 837 5 - - SYM cord-014516-r59usk02 837 6 0.378 0.378 CD cord-014516-r59usk02 837 7 ) ) -RRB- cord-014516-r59usk02 837 8 . . . cord-014516-r59usk02 838 1 No no DT cord-014516-r59usk02 838 2 significant significant JJ cord-014516-r59usk02 838 3 difference difference NN cord-014516-r59usk02 838 4 was be VBD cord-014516-r59usk02 838 5 noted note VBN cord-014516-r59usk02 838 6 between between IN cord-014516-r59usk02 838 7 6 6 CD cord-014516-r59usk02 838 8 week week NN cord-014516-r59usk02 838 9 and and CC cord-014516-r59usk02 838 10 6 6 CD cord-014516-r59usk02 838 11 month month NN cord-014516-r59usk02 838 12 period period NN cord-014516-r59usk02 838 13 comparing compare VBG cord-014516-r59usk02 838 14 to to IN cord-014516-r59usk02 838 15 time time NN cord-014516-r59usk02 838 16 zero zero CD cord-014516-r59usk02 838 17 ( ( -LRB- cord-014516-r59usk02 838 18 P p NN cord-014516-r59usk02 838 19 = = SYM cord-014516-r59usk02 838 20 0.84 0.84 CD cord-014516-r59usk02 838 21 and and CC cord-014516-r59usk02 838 22 P p NN cord-014516-r59usk02 838 23 = = SYM cord-014516-r59usk02 838 24 0.37 0.37 CD cord-014516-r59usk02 838 25 ) ) -RRB- cord-014516-r59usk02 838 26 . . . cord-014516-r59usk02 839 1 Serum serum NN cord-014516-r59usk02 839 2 prolactin prolactin NN cord-014516-r59usk02 839 3 concentration concentration NN cord-014516-r59usk02 839 4 measured measure VBN cord-014516-r59usk02 839 5 in in IN cord-014516-r59usk02 839 6 22/23 22/23 CD cord-014516-r59usk02 839 7 dogs dog NNS cord-014516-r59usk02 839 8 at at IN cord-014516-r59usk02 839 9 time time NN cord-014516-r59usk02 839 10 zero zero CD cord-014516-r59usk02 839 11 , , , cord-014516-r59usk02 839 12 6 6 CD cord-014516-r59usk02 839 13 weeks week NNS cord-014516-r59usk02 839 14 and and CC cord-014516-r59usk02 839 15 6 6 CD cord-014516-r59usk02 839 16 months month NNS cord-014516-r59usk02 839 17 was be VBD cord-014516-r59usk02 839 18 3.35 3.35 CD cord-014516-r59usk02 839 19 ng ng NN cord-014516-r59usk02 839 20 / / SYM cord-014516-r59usk02 839 21 ml ml NN cord-014516-r59usk02 839 22 ( ( -LRB- cord-014516-r59usk02 839 23 range range NN cord-014516-r59usk02 839 24 , , , cord-014516-r59usk02 839 25 1.4 1.4 CD cord-014516-r59usk02 839 26 - - SYM cord-014516-r59usk02 839 27 6.36 6.36 CD cord-014516-r59usk02 839 28 ) ) -RRB- cord-014516-r59usk02 839 29 , , , cord-014516-r59usk02 839 30 3.57 3.57 CD cord-014516-r59usk02 839 31 ng ng NN cord-014516-r59usk02 839 32 / / SYM cord-014516-r59usk02 839 33 ml ml NN cord-014516-r59usk02 839 34 ( ( -LRB- cord-014516-r59usk02 839 35 range range NN cord-014516-r59usk02 839 36 , , , cord-014516-r59usk02 839 37 1.87 1.87 CD cord-014516-r59usk02 839 38 - - SYM cord-014516-r59usk02 839 39 7.39 7.39 CD cord-014516-r59usk02 839 40 ) ) -RRB- cord-014516-r59usk02 839 41 and and CC cord-014516-r59usk02 839 42 3.92 3.92 CD cord-014516-r59usk02 839 43 ng ng NN cord-014516-r59usk02 839 44 / / SYM cord-014516-r59usk02 839 45 ml ml NN cord-014516-r59usk02 839 46 ( ( -LRB- cord-014516-r59usk02 839 47 range range NN cord-014516-r59usk02 839 48 , , , cord-014516-r59usk02 839 49 2.01 2.01 CD cord-014516-r59usk02 839 50 - - SYM cord-014516-r59usk02 839 51 12.92 12.92 CD cord-014516-r59usk02 839 52 ) ) -RRB- cord-014516-r59usk02 839 53 and and CC cord-014516-r59usk02 839 54 did do VBD cord-014516-r59usk02 839 55 not not RB cord-014516-r59usk02 839 56 differ differ VB cord-014516-r59usk02 839 57 significantly significantly RB cord-014516-r59usk02 839 58 in in IN cord-014516-r59usk02 839 59 either either DT cord-014516-r59usk02 839 60 time time NN cord-014516-r59usk02 839 61 period period NN cord-014516-r59usk02 839 62 when when WRB cord-014516-r59usk02 839 63 compared compare VBN cord-014516-r59usk02 839 64 with with IN cord-014516-r59usk02 839 65 time time NN cord-014516-r59usk02 839 66 zero zero CD cord-014516-r59usk02 839 67 ( ( -LRB- cord-014516-r59usk02 839 68 P p NN cord-014516-r59usk02 839 69 = = SYM cord-014516-r59usk02 839 70 0.99 0.99 CD cord-014516-r59usk02 839 71 and and CC cord-014516-r59usk02 839 72 P p NN cord-014516-r59usk02 839 73 = = SYM cord-014516-r59usk02 839 74 0.52).Altogether 0.52).altogether CD cord-014516-r59usk02 839 75 , , , cord-014516-r59usk02 839 76 results result NNS cord-014516-r59usk02 839 77 of of IN cord-014516-r59usk02 839 78 this this DT cord-014516-r59usk02 839 79 study study NN cord-014516-r59usk02 839 80 failed fail VBD cord-014516-r59usk02 839 81 to to TO cord-014516-r59usk02 839 82 demonstrate demonstrate VB cord-014516-r59usk02 839 83 a a DT cord-014516-r59usk02 839 84 significant significant JJ cord-014516-r59usk02 839 85 role role NN cord-014516-r59usk02 839 86 of of IN cord-014516-r59usk02 839 87 thyroid thyroid JJ cord-014516-r59usk02 839 88 supplementation supplementation NN cord-014516-r59usk02 839 89 on on IN cord-014516-r59usk02 839 90 the the DT cord-014516-r59usk02 839 91 majority majority NN cord-014516-r59usk02 839 92 of of IN cord-014516-r59usk02 839 93 evaluated evaluate VBN cord-014516-r59usk02 839 94 behavioural behavioural JJ cord-014516-r59usk02 839 95 symptoms symptom NNS cord-014516-r59usk02 839 96 as as RB cord-014516-r59usk02 839 97 well well RB cord-014516-r59usk02 839 98 as as IN cord-014516-r59usk02 839 99 neurohormonal neurohormonal JJ cord-014516-r59usk02 839 100 status status NN cord-014516-r59usk02 839 101 of of IN cord-014516-r59usk02 839 102 hypothyroid hypothyroid JJ cord-014516-r59usk02 839 103 dogs dog NNS cord-014516-r59usk02 839 104 during during IN cord-014516-r59usk02 839 105 6 6 CD cord-014516-r59usk02 839 106 months month NNS cord-014516-r59usk02 839 107 of of IN cord-014516-r59usk02 839 108 therapy therapy NN cord-014516-r59usk02 839 109 . . . cord-014516-r59usk02 840 1 No no DT cord-014516-r59usk02 840 2 conflicts conflict NNS cord-014516-r59usk02 840 3 of of IN cord-014516-r59usk02 840 4 interest interest NN cord-014516-r59usk02 840 5 reported report VBN cord-014516-r59usk02 840 6 . . . cord-014516-r59usk02 841 1 Iatrogenic iatrogenic JJ cord-014516-r59usk02 841 2 hypothyroidism hypothyroidism NN cord-014516-r59usk02 841 3 is be VBZ cord-014516-r59usk02 841 4 a a DT cord-014516-r59usk02 841 5 recognized recognize VBN cord-014516-r59usk02 841 6 complication complication NN cord-014516-r59usk02 841 7 of of IN cord-014516-r59usk02 841 8 radioiodine radioiodine NN cord-014516-r59usk02 841 9 treatment treatment NN cord-014516-r59usk02 841 10 of of IN cord-014516-r59usk02 841 11 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 841 12 in in IN cord-014516-r59usk02 841 13 cats cat NNS cord-014516-r59usk02 841 14 , , , cord-014516-r59usk02 841 15 but but CC cord-014516-r59usk02 841 16 no no DT cord-014516-r59usk02 841 17 prospective prospective JJ cord-014516-r59usk02 841 18 studies study NNS cord-014516-r59usk02 841 19 of of IN cord-014516-r59usk02 841 20 the the DT cord-014516-r59usk02 841 21 prevalence prevalence NN cord-014516-r59usk02 841 22 , , , cord-014516-r59usk02 841 23 clinical clinical JJ cord-014516-r59usk02 841 24 features feature NNS cord-014516-r59usk02 841 25 , , , cord-014516-r59usk02 841 26 routine routine JJ cord-014516-r59usk02 841 27 laboratory laboratory NN cord-014516-r59usk02 841 28 findings finding NNS cord-014516-r59usk02 841 29 , , , cord-014516-r59usk02 841 30 or or CC cord-014516-r59usk02 841 31 results result NNS cord-014516-r59usk02 841 32 of of IN cord-014516-r59usk02 841 33 thyroid thyroid NN cord-014516-r59usk02 841 34 function function NN cord-014516-r59usk02 841 35 tests test NNS cord-014516-r59usk02 841 36 have have VBP cord-014516-r59usk02 841 37 been be VBN cord-014516-r59usk02 841 38 reported report VBN cord-014516-r59usk02 841 39 in in IN cord-014516-r59usk02 841 40 a a DT cord-014516-r59usk02 841 41 series series NN cord-014516-r59usk02 841 42 of of IN cord-014516-r59usk02 841 43 hypothyroid hypothyroid JJ cord-014516-r59usk02 841 44 cats cat NNS cord-014516-r59usk02 841 45 . . . cord-014516-r59usk02 842 1 In in IN cord-014516-r59usk02 842 2 this this DT cord-014516-r59usk02 842 3 study study NN cord-014516-r59usk02 842 4 , , , cord-014516-r59usk02 842 5 we -PRON- PRP cord-014516-r59usk02 842 6 describe describe VBP cord-014516-r59usk02 842 7 the the DT cord-014516-r59usk02 842 8 features feature NNS cord-014516-r59usk02 842 9 of of IN cord-014516-r59usk02 842 10 hypothyroidism hypothyroidism NN cord-014516-r59usk02 842 11 in in IN cord-014516-r59usk02 842 12 35 35 CD cord-014516-r59usk02 842 13 cats cat NNS cord-014516-r59usk02 842 14 treated treat VBN cord-014516-r59usk02 842 15 with with IN cord-014516-r59usk02 842 16 radioiodine radioiodine NN cord-014516-r59usk02 842 17 over over IN cord-014516-r59usk02 842 18 a a DT cord-014516-r59usk02 842 19 15-month 15-month JJ cord-014516-r59usk02 842 20 period period NN cord-014516-r59usk02 842 21 ( ( -LRB- cord-014516-r59usk02 842 22 October October NNP cord-014516-r59usk02 842 23 2012-March 2012-march CD cord-014516-r59usk02 842 24 2014 2014 CD cord-014516-r59usk02 842 25 ) ) -RRB- cord-014516-r59usk02 842 26 . . . cord-014516-r59usk02 843 1 During during IN cord-014516-r59usk02 843 2 this this DT cord-014516-r59usk02 843 3 same same JJ cord-014516-r59usk02 843 4 period period NN cord-014516-r59usk02 843 5 , , , cord-014516-r59usk02 843 6 we -PRON- PRP cord-014516-r59usk02 843 7 treated treat VBD cord-014516-r59usk02 843 8 % % NN cord-014516-r59usk02 843 9 500 500 CD cord-014516-r59usk02 843 10 hyperthyroid hyperthyroid JJ cord-014516-r59usk02 843 11 cats cat NNS cord-014516-r59usk02 843 12 with with IN cord-014516-r59usk02 843 13 radioiodine radioiodine NN cord-014516-r59usk02 843 14 , , , cord-014516-r59usk02 843 15 providing provide VBG cord-014516-r59usk02 843 16 a a DT cord-014516-r59usk02 843 17 prevalence prevalence NN cord-014516-r59usk02 843 18 rate rate NN cord-014516-r59usk02 843 19 of of IN cord-014516-r59usk02 843 20 7 7 CD cord-014516-r59usk02 843 21 % % NN cord-014516-r59usk02 843 22 . . . cord-014516-r59usk02 844 1 Hypothyroidism hypothyroidism NN cord-014516-r59usk02 844 2 was be VBD cord-014516-r59usk02 844 3 diagnosed diagnose VBN cord-014516-r59usk02 844 4 41 41 CD cord-014516-r59usk02 844 5 - - SYM cord-014516-r59usk02 844 6 814 814 CD cord-014516-r59usk02 844 7 days day NNS cord-014516-r59usk02 844 8 ( ( -LRB- cord-014516-r59usk02 844 9 median median NN cord-014516-r59usk02 844 10 , , , cord-014516-r59usk02 844 11 120 120 CD cord-014516-r59usk02 844 12 days day NNS cord-014516-r59usk02 844 13 ) ) -RRB- cord-014516-r59usk02 844 14 after after IN cord-014516-r59usk02 844 15 131 131 CD cord-014516-r59usk02 844 16 I i NN cord-014516-r59usk02 844 17 treatment treatment NN cord-014516-r59usk02 844 18 , , , cord-014516-r59usk02 844 19 with with IN cord-014516-r59usk02 844 20 doses dose NNS cord-014516-r59usk02 844 21 ranging range VBG cord-014516-r59usk02 844 22 from from IN cord-014516-r59usk02 844 23 65 65 CD cord-014516-r59usk02 844 24 - - SYM cord-014516-r59usk02 844 25 1000 1000 CD cord-014516-r59usk02 844 26 Mbq Mbq NNP cord-014516-r59usk02 844 27 ( ( -LRB- cord-014516-r59usk02 844 28 median median NN cord-014516-r59usk02 844 29 , , , cord-014516-r59usk02 844 30 100 100 CD cord-014516-r59usk02 844 31 Mbq Mbq NNP cord-014516-r59usk02 844 32 ; ; : cord-014516-r59usk02 844 33 median median JJ cord-014516-r59usk02 844 34 pretreatment pretreatment NN cord-014516-r59usk02 844 35 T4 T4 NNP cord-014516-r59usk02 844 36 , , , cord-014516-r59usk02 844 37 142 142 CD cord-014516-r59usk02 844 38 nmol nmol NNP cord-014516-r59usk02 844 39 / / SYM cord-014516-r59usk02 844 40 L L NNP cord-014516-r59usk02 844 41 ) ) -RRB- cord-014516-r59usk02 844 42 . . . cord-014516-r59usk02 845 1 The the DT cord-014516-r59usk02 845 2 35 35 CD cord-014516-r59usk02 845 3 hypothyroid hypothyroid JJ cord-014516-r59usk02 845 4 cats cat NNS cord-014516-r59usk02 845 5 ranged range VBD cord-014516-r59usk02 845 6 in in IN cord-014516-r59usk02 845 7 age age NN cord-014516-r59usk02 845 8 from from IN cord-014516-r59usk02 845 9 9 9 CD cord-014516-r59usk02 845 10 - - SYM cord-014516-r59usk02 845 11 19 19 CD cord-014516-r59usk02 845 12 years year NNS cord-014516-r59usk02 845 13 ( ( -LRB- cord-014516-r59usk02 845 14 median median NN cord-014516-r59usk02 845 15 , , , cord-014516-r59usk02 845 16 13 13 CD cord-014516-r59usk02 845 17 years year NNS cord-014516-r59usk02 845 18 ) ) -RRB- cord-014516-r59usk02 845 19 . . . cord-014516-r59usk02 846 1 All all DT cord-014516-r59usk02 846 2 were be VBD cord-014516-r59usk02 846 3 DSH DSH NNP cord-014516-r59usk02 846 4 / / SYM cord-014516-r59usk02 846 5 DLH DLH NNP cord-014516-r59usk02 846 6 ; ; : cord-014516-r59usk02 846 7 28 28 CD cord-014516-r59usk02 846 8 ( ( -LRB- cord-014516-r59usk02 846 9 80 80 CD cord-014516-r59usk02 846 10 % % NN cord-014516-r59usk02 846 11 ) ) -RRB- cord-014516-r59usk02 846 12 were be VBD cord-014516-r59usk02 846 13 female female JJ cord-014516-r59usk02 846 14 and and CC cord-014516-r59usk02 846 15 7 7 CD cord-014516-r59usk02 846 16 were be VBD cord-014516-r59usk02 846 17 males male NNS cord-014516-r59usk02 846 18 ( ( -LRB- cord-014516-r59usk02 846 19 P p NN cord-014516-r59usk02 846 20 = = SYM cord-014516-r59usk02 846 21 0.0004 0.0004 CD cord-014516-r59usk02 846 22 ) ) -RRB- cord-014516-r59usk02 846 23 . . . cord-014516-r59usk02 847 1 Clinical clinical JJ cord-014516-r59usk02 847 2 signs sign NNS cord-014516-r59usk02 847 3 in in IN cord-014516-r59usk02 847 4 these these DT cord-014516-r59usk02 847 5 35 35 CD cord-014516-r59usk02 847 6 cats cat NNS cord-014516-r59usk02 847 7 included include VBD cord-014516-r59usk02 847 8 overweight overweight JJ cord-014516-r59usk02 847 9 / / SYM cord-014516-r59usk02 847 10 obesity obesity NN cord-014516-r59usk02 847 11 in in IN cord-014516-r59usk02 847 12 6 6 CD cord-014516-r59usk02 847 13 ( ( -LRB- cord-014516-r59usk02 847 14 17 17 CD cord-014516-r59usk02 847 15 % % NN cord-014516-r59usk02 847 16 ) ) -RRB- cord-014516-r59usk02 847 17 , , , cord-014516-r59usk02 847 18 lethargy lethargy NN cord-014516-r59usk02 847 19 / / SYM cord-014516-r59usk02 847 20 dullness dullness NN cord-014516-r59usk02 847 21 in in IN cord-014516-r59usk02 847 22 6 6 CD cord-014516-r59usk02 847 23 ( ( -LRB- cord-014516-r59usk02 847 24 17 17 CD cord-014516-r59usk02 847 25 % % NN cord-014516-r59usk02 847 26 ) ) -RRB- cord-014516-r59usk02 847 27 , , , cord-014516-r59usk02 847 28 poor poor JJ cord-014516-r59usk02 847 29 appetite appetite NN cord-014516-r59usk02 847 30 in in IN cord-014516-r59usk02 847 31 3 3 CD cord-014516-r59usk02 847 32 ( ( -LRB- cord-014516-r59usk02 847 33 8.6 8.6 CD cord-014516-r59usk02 847 34 % % NN cord-014516-r59usk02 847 35 ) ) -RRB- cord-014516-r59usk02 847 36 , , , cord-014516-r59usk02 847 37 and and CC cord-014516-r59usk02 847 38 polyuria polyuria NN cord-014516-r59usk02 847 39 / / , cord-014516-r59usk02 847 40 polydipsia polydipsia NN cord-014516-r59usk02 847 41 in in IN cord-014516-r59usk02 847 42 9 9 CD cord-014516-r59usk02 847 43 ( ( -LRB- cord-014516-r59usk02 847 44 26 26 CD cord-014516-r59usk02 847 45 % % NN cord-014516-r59usk02 847 46 ) ) -RRB- cord-014516-r59usk02 847 47 . . . cord-014516-r59usk02 848 1 Abnormalities abnormality NNS cord-014516-r59usk02 848 2 on on IN cord-014516-r59usk02 848 3 physical physical JJ cord-014516-r59usk02 848 4 examination examination NN cord-014516-r59usk02 848 5 included include VBD cord-014516-r59usk02 848 6 dermatologic dermatologic JJ cord-014516-r59usk02 848 7 signs sign NNS cord-014516-r59usk02 848 8 ( ( -LRB- cord-014516-r59usk02 848 9 dry dry JJ cord-014516-r59usk02 848 10 coat coat NN cord-014516-r59usk02 848 11 , , , cord-014516-r59usk02 848 12 seborrhea seborrhea NN cord-014516-r59usk02 848 13 , , , cord-014516-r59usk02 848 14 matting matting NN cord-014516-r59usk02 848 15 ) ) -RRB- cord-014516-r59usk02 848 16 in in IN cord-014516-r59usk02 848 17 5 5 CD cord-014516-r59usk02 848 18 ( ( -LRB- cord-014516-r59usk02 848 19 14 14 CD cord-014516-r59usk02 848 20 % % NN cord-014516-r59usk02 848 21 ) ) -RRB- cord-014516-r59usk02 848 22 and and CC cord-014516-r59usk02 848 23 bradycardia bradycardia JJ cord-014516-r59usk02 848 24 ( ( -LRB- cord-014516-r59usk02 848 25 < < XX cord-014516-r59usk02 848 26 150 150 CD cord-014516-r59usk02 848 27 bpm bpm NNS cord-014516-r59usk02 848 28 ) ) -RRB- cord-014516-r59usk02 848 29 in in IN cord-014516-r59usk02 848 30 2 2 CD cord-014516-r59usk02 848 31 . . . cord-014516-r59usk02 849 1 Twenty twenty CD cord-014516-r59usk02 849 2 - - HYPH cord-014516-r59usk02 849 3 two two CD cord-014516-r59usk02 849 4 cats cat NNS cord-014516-r59usk02 849 5 ( ( -LRB- cord-014516-r59usk02 849 6 63 63 CD cord-014516-r59usk02 849 7 % % NN cord-014516-r59usk02 849 8 ) ) -RRB- cord-014516-r59usk02 849 9 had have VBD cord-014516-r59usk02 849 10 no no DT cord-014516-r59usk02 849 11 noticeable noticeable JJ cord-014516-r59usk02 849 12 clinical clinical JJ cord-014516-r59usk02 849 13 features feature NNS cord-014516-r59usk02 849 14 of of IN cord-014516-r59usk02 849 15 hypothyroidism hypothyroidism NN cord-014516-r59usk02 849 16 . . . cord-014516-r59usk02 850 1 Routine routine JJ cord-014516-r59usk02 850 2 laboratory laboratory NN cord-014516-r59usk02 850 3 abnormalities abnormality NNS cord-014516-r59usk02 850 4 included include VBD cord-014516-r59usk02 850 5 hypercholesterolemia hypercholesterolemia NN cord-014516-r59usk02 850 6 ( ( -LRB- cord-014516-r59usk02 850 7 > > NFP cord-014516-r59usk02 850 8 6 6 CD cord-014516-r59usk02 850 9 mmol mmol NNP cord-014516-r59usk02 850 10 / / SYM cord-014516-r59usk02 850 11 L L NNP cord-014516-r59usk02 850 12 ) ) -RRB- cord-014516-r59usk02 850 13 in in IN cord-014516-r59usk02 850 14 7 7 CD cord-014516-r59usk02 850 15 ( ( -LRB- cord-014516-r59usk02 850 16 20 20 CD cord-014516-r59usk02 850 17 % % NN cord-014516-r59usk02 850 18 ) ) -RRB- cord-014516-r59usk02 850 19 and and CC cord-014516-r59usk02 850 20 new new JJ cord-014516-r59usk02 850 21 or or CC cord-014516-r59usk02 850 22 worsening worsen VBG cord-014516-r59usk02 850 23 azotemia azotemia NN cord-014516-r59usk02 850 24 ( ( -LRB- cord-014516-r59usk02 850 25 > > NFP cord-014516-r59usk02 850 26 140 140 CD cord-014516-r59usk02 850 27 lmol lmol NNP cord-014516-r59usk02 850 28 / / SYM cord-014516-r59usk02 850 29 L L NNP cord-014516-r59usk02 850 30 ) ) -RRB- cord-014516-r59usk02 850 31 in in IN cord-014516-r59usk02 850 32 26 26 CD cord-014516-r59usk02 850 33 ( ( -LRB- cord-014516-r59usk02 850 34 74 74 CD cord-014516-r59usk02 850 35 % % NN cord-014516-r59usk02 850 36 ) ) -RRB- cord-014516-r59usk02 850 37 and and CC cord-014516-r59usk02 850 38 4 4 CD cord-014516-r59usk02 850 39 ( ( -LRB- cord-014516-r59usk02 850 40 11 11 CD cord-014516-r59usk02 850 41 % % NN cord-014516-r59usk02 850 42 ) ) -RRB- cord-014516-r59usk02 850 43 cats cat NNS cord-014516-r59usk02 850 44 , , , cord-014516-r59usk02 850 45 respectively respectively RB cord-014516-r59usk02 850 46 . . . cord-014516-r59usk02 851 1 Median median JJ cord-014516-r59usk02 851 2 serum serum NN cord-014516-r59usk02 851 3 concentrations concentration NNS cord-014516-r59usk02 851 4 of of IN cord-014516-r59usk02 851 5 total total JJ cord-014516-r59usk02 851 6 T4 T4 NNP cord-014516-r59usk02 851 7 ( ( -LRB- cord-014516-r59usk02 851 8 11.6 11.6 CD cord-014516-r59usk02 851 9 nmol nmol NNP cord-014516-r59usk02 851 10 / / SYM cord-014516-r59usk02 851 11 L l NN cord-014516-r59usk02 851 12 ; ; : cord-014516-r59usk02 851 13 reference reference NN cord-014516-r59usk02 851 14 interval interval NN cord-014516-r59usk02 851 15 [ [ -LRB- cord-014516-r59usk02 851 16 RI RI NNP cord-014516-r59usk02 851 17 ] ] -RRB- cord-014516-r59usk02 851 18 , , , cord-014516-r59usk02 851 19 10 10 CD cord-014516-r59usk02 851 20 - - SYM cord-014516-r59usk02 851 21 50 50 CD cord-014516-r59usk02 851 22 nmol nmol JJ cord-014516-r59usk02 851 23 / / SYM cord-014516-r59usk02 851 24 L L NNP cord-014516-r59usk02 851 25 ) ) -RRB- cord-014516-r59usk02 851 26 , , , cord-014516-r59usk02 851 27 T3 T3 NNP cord-014516-r59usk02 851 28 ( ( -LRB- cord-014516-r59usk02 851 29 0.6 0.6 CD cord-014516-r59usk02 851 30 nmol nmol JJ cord-014516-r59usk02 851 31 / / SYM cord-014516-r59usk02 851 32 L l NN cord-014516-r59usk02 851 33 ; ; : cord-014516-r59usk02 851 34 RI RI NNP cord-014516-r59usk02 851 35 , , , cord-014516-r59usk02 851 36 0.5 0.5 CD cord-014516-r59usk02 851 37 - - SYM cord-014516-r59usk02 851 38 0.8 0.8 CD cord-014516-r59usk02 851 39 nmol nmol NN cord-014516-r59usk02 851 40 / / SYM cord-014516-r59usk02 851 41 L L NNP cord-014516-r59usk02 851 42 ) ) -RRB- cord-014516-r59usk02 851 43 , , , cord-014516-r59usk02 851 44 and and CC cord-014516-r59usk02 851 45 FT4 FT4 NNP cord-014516-r59usk02 851 46 ( ( -LRB- cord-014516-r59usk02 851 47 15 15 CD cord-014516-r59usk02 851 48 pmol pmol NNP cord-014516-r59usk02 851 49 / / SYM cord-014516-r59usk02 851 50 L l NN cord-014516-r59usk02 851 51 ; ; : cord-014516-r59usk02 851 52 RI RI NNP cord-014516-r59usk02 851 53 , , , cord-014516-r59usk02 851 54 10 10 CD cord-014516-r59usk02 851 55 - - SYM cord-014516-r59usk02 851 56 50 50 CD cord-014516-r59usk02 851 57 pmol pmol NN cord-014516-r59usk02 851 58 / / SYM cord-014516-r59usk02 851 59 L l NN cord-014516-r59usk02 851 60 ) ) -RRB- cord-014516-r59usk02 851 61 were be VBD cord-014516-r59usk02 851 62 all all DT cord-014516-r59usk02 851 63 in in IN cord-014516-r59usk02 851 64 the the DT cord-014516-r59usk02 851 65 low low JJ cord-014516-r59usk02 851 66 end end NN cord-014516-r59usk02 851 67 of of IN cord-014516-r59usk02 851 68 the the DT cord-014516-r59usk02 851 69 RI RI NNP cord-014516-r59usk02 851 70 . . . cord-014516-r59usk02 852 1 Normal normal JJ cord-014516-r59usk02 852 2 RI RI NNP cord-014516-r59usk02 852 3 values value NNS cord-014516-r59usk02 852 4 for for IN cord-014516-r59usk02 852 5 T4 T4 NNP cord-014516-r59usk02 852 6 and and CC cord-014516-r59usk02 852 7 FT4 FT4 NNP cord-014516-r59usk02 852 8 were be VBD cord-014516-r59usk02 852 9 maintained maintain VBN cord-014516-r59usk02 852 10 in in IN cord-014516-r59usk02 852 11 22 22 CD cord-014516-r59usk02 852 12 ( ( -LRB- cord-014516-r59usk02 852 13 63 63 CD cord-014516-r59usk02 852 14 % % NN cord-014516-r59usk02 852 15 ) ) -RRB- cord-014516-r59usk02 852 16 and and CC cord-014516-r59usk02 852 17 30 30 CD cord-014516-r59usk02 852 18 ( ( -LRB- cord-014516-r59usk02 852 19 86 86 CD cord-014516-r59usk02 852 20 % % NN cord-014516-r59usk02 852 21 ) ) -RRB- cord-014516-r59usk02 852 22 of of IN cord-014516-r59usk02 852 23 the the DT cord-014516-r59usk02 852 24 cats cat NNS cord-014516-r59usk02 852 25 , , , cord-014516-r59usk02 852 26 respectively respectively RB cord-014516-r59usk02 852 27 . . . cord-014516-r59usk02 853 1 Serum serum NN cord-014516-r59usk02 853 2 cTSH ctsh IN cord-014516-r59usk02 853 3 values value NNS cord-014516-r59usk02 853 4 were be VBD cord-014516-r59usk02 853 5 high high JJ cord-014516-r59usk02 853 6 in in IN cord-014516-r59usk02 853 7 all all DT cord-014516-r59usk02 853 8 cats cat NNS cord-014516-r59usk02 853 9 ( ( -LRB- cord-014516-r59usk02 853 10 median median NN cord-014516-r59usk02 853 11 , , , cord-014516-r59usk02 853 12 3.3 3.3 CD cord-014516-r59usk02 853 13 ng ng NN cord-014516-r59usk02 853 14 / / SYM cord-014516-r59usk02 853 15 dl dl NN cord-014516-r59usk02 853 16 ; ; : cord-014516-r59usk02 853 17 range range NN cord-014516-r59usk02 853 18 , , , cord-014516-r59usk02 853 19 0.47 0.47 CD cord-014516-r59usk02 853 20 - - SYM cord-014516-r59usk02 853 21 12.0 12.0 CD cord-014516-r59usk02 853 22 ng ng NN cord-014516-r59usk02 853 23 / / SYM cord-014516-r59usk02 853 24 dl dl NN cord-014516-r59usk02 853 25 ; ; : cord-014516-r59usk02 853 26 RI RI NNP cord-014516-r59usk02 853 27 , , , cord-014516-r59usk02 853 28 0.03 0.03 CD cord-014516-r59usk02 853 29 - - SYM cord-014516-r59usk02 853 30 0.30 0.30 CD cord-014516-r59usk02 853 31 ng ng NNP cord-014516-r59usk02 853 32 / / SYM cord-014516-r59usk02 853 33 ml ml NN cord-014516-r59usk02 853 34 ) ) -RRB- cord-014516-r59usk02 853 35 . . . cord-014516-r59usk02 854 1 Thyroid thyroid NN cord-014516-r59usk02 854 2 scintigraphy scintigraphy NN cord-014516-r59usk02 854 3 showed show VBD cord-014516-r59usk02 854 4 less less JJR cord-014516-r59usk02 854 5 - - HYPH cord-014516-r59usk02 854 6 than than IN cord-014516-r59usk02 854 7 - - HYPH cord-014516-r59usk02 854 8 normal normal JJ cord-014516-r59usk02 854 9 amounts amount NNS cord-014516-r59usk02 854 10 of of IN cord-014516-r59usk02 854 11 residual residual JJ cord-014516-r59usk02 854 12 tissue tissue NN cord-014516-r59usk02 854 13 , , , cord-014516-r59usk02 854 14 as as RB cord-014516-r59usk02 854 15 well well RB cord-014516-r59usk02 854 16 as as IN cord-014516-r59usk02 854 17 low low JJ cord-014516-r59usk02 854 18 values value NNS cord-014516-r59usk02 854 19 for for IN cord-014516-r59usk02 854 20 thyroid thyroid NN cord-014516-r59usk02 854 21 - - HYPH cord-014516-r59usk02 854 22 to to IN cord-014516-r59usk02 854 23 - - HYPH cord-014516-r59usk02 854 24 salivary salivary NN cord-014516-r59usk02 854 25 ratio ratio NN cord-014516-r59usk02 854 26 and and CC cord-014516-r59usk02 854 27 % % NN cord-014516-r59usk02 854 28 -uptake -uptake NN cord-014516-r59usk02 854 29 of of IN cord-014516-r59usk02 854 30 pertechnetate pertechnetate NNP cord-014516-r59usk02 854 31 , , , cord-014516-r59usk02 854 32 in in IN cord-014516-r59usk02 854 33 30 30 CD cord-014516-r59usk02 854 34 ( ( -LRB- cord-014516-r59usk02 854 35 86 86 CD cord-014516-r59usk02 854 36 % % NN cord-014516-r59usk02 854 37 ) ) -RRB- cord-014516-r59usk02 854 38 . . . cord-014516-r59usk02 855 1 Of of IN cord-014516-r59usk02 855 2 those those DT cord-014516-r59usk02 855 3 5 5 CD cord-014516-r59usk02 855 4 cats cat NNS cord-014516-r59usk02 855 5 with with IN cord-014516-r59usk02 855 6 normal normal JJ cord-014516-r59usk02 855 7 scintiscans scintiscan NNS cord-014516-r59usk02 855 8 , , , cord-014516-r59usk02 855 9 serum serum NN cord-014516-r59usk02 855 10 cTSH cTSH NNP cord-014516-r59usk02 855 11 decreased decrease VBD cord-014516-r59usk02 855 12 into into IN cord-014516-r59usk02 855 13 the the DT cord-014516-r59usk02 855 14 RI RI NNP cord-014516-r59usk02 855 15 without without IN cord-014516-r59usk02 855 16 treatment treatment NN cord-014516-r59usk02 855 17 when when WRB cord-014516-r59usk02 855 18 retested reteste VBN cord-014516-r59usk02 855 19 1 1 CD cord-014516-r59usk02 855 20 - - SYM cord-014516-r59usk02 855 21 6 6 CD cord-014516-r59usk02 855 22 months month NNS cord-014516-r59usk02 855 23 later later RB cord-014516-r59usk02 855 24 . . . cord-014516-r59usk02 856 1 In in IN cord-014516-r59usk02 856 2 conclusion conclusion NN cord-014516-r59usk02 856 3 , , , cord-014516-r59usk02 856 4 this this DT cord-014516-r59usk02 856 5 study study NN cord-014516-r59usk02 856 6 confirms confirm VBZ cord-014516-r59usk02 856 7 that that IN cord-014516-r59usk02 856 8 131 131 CD cord-014516-r59usk02 856 9 I i NN cord-014516-r59usk02 856 10 - - HYPH cord-014516-r59usk02 856 11 induced induce VBN cord-014516-r59usk02 856 12 hypothyroidism hypothyroidism NN cord-014516-r59usk02 856 13 is be VBZ cord-014516-r59usk02 856 14 not not RB cord-014516-r59usk02 856 15 uncommon uncommon JJ cord-014516-r59usk02 856 16 , , , cord-014516-r59usk02 856 17 with with IN cord-014516-r59usk02 856 18 an an DT cord-014516-r59usk02 856 19 apparent apparent JJ cord-014516-r59usk02 856 20 female female JJ cord-014516-r59usk02 856 21 sex sex NN cord-014516-r59usk02 856 22 predilection predilection NN cord-014516-r59usk02 856 23 . . . cord-014516-r59usk02 857 1 Serum serum NN cord-014516-r59usk02 857 2 T4 T4 NNP cord-014516-r59usk02 857 3 and and CC cord-014516-r59usk02 857 4 FT4 ft4 NN cord-014516-r59usk02 857 5 remain remain VBP cord-014516-r59usk02 857 6 normal normal JJ cord-014516-r59usk02 857 7 in in IN cord-014516-r59usk02 857 8 most most JJS cord-014516-r59usk02 857 9 cats cat NNS cord-014516-r59usk02 857 10 , , , cord-014516-r59usk02 857 11 but but CC cord-014516-r59usk02 857 12 high high JJ cord-014516-r59usk02 857 13 serum serum NN cord-014516-r59usk02 857 14 cTSH ctsh IN cord-014516-r59usk02 857 15 values value NNS cord-014516-r59usk02 857 16 and and CC cord-014516-r59usk02 857 17 thyroid thyroid NN cord-014516-r59usk02 857 18 scintigraphy scintigraphy NN cord-014516-r59usk02 857 19 aid aid NN cord-014516-r59usk02 857 20 in in IN cord-014516-r59usk02 857 21 diagnosis diagnosis NN cord-014516-r59usk02 857 22 . . . cord-014516-r59usk02 858 1 Unless unless IN cord-014516-r59usk02 858 2 cats cat NNS cord-014516-r59usk02 858 3 have have VBP cord-014516-r59usk02 858 4 overt overt JJ cord-014516-r59usk02 858 5 , , , cord-014516-r59usk02 858 6 long long RB cord-014516-r59usk02 858 7 - - HYPH cord-014516-r59usk02 858 8 standing stand VBG cord-014516-r59usk02 858 9 hypothyroidism hypothyroidism NN cord-014516-r59usk02 858 10 , , , cord-014516-r59usk02 858 11 most most JJS cord-014516-r59usk02 858 12 cats cat NNS cord-014516-r59usk02 858 13 with with IN cord-014516-r59usk02 858 14 subclinical subclinical JJ cord-014516-r59usk02 858 15 disease disease NN cord-014516-r59usk02 858 16 are be VBP cord-014516-r59usk02 858 17 relatively relatively RB cord-014516-r59usk02 858 18 asymptomatic asymptomatic JJ cord-014516-r59usk02 858 19 , , , cord-014516-r59usk02 858 20 other other JJ cord-014516-r59usk02 858 21 than than IN cord-014516-r59usk02 858 22 worsening worsen VBG cord-014516-r59usk02 858 23 azotemia azotemia NN cord-014516-r59usk02 858 24 . . . cord-014516-r59usk02 859 1 Subclinical subclinical JJ cord-014516-r59usk02 859 2 hypothyroidism hypothyroidism NN cord-014516-r59usk02 859 3 will will MD cord-014516-r59usk02 859 4 be be VB cord-014516-r59usk02 859 5 transient transient JJ cord-014516-r59usk02 859 6 in in IN cord-014516-r59usk02 859 7 some some DT cord-014516-r59usk02 859 8 cats cat NNS cord-014516-r59usk02 859 9 , , , cord-014516-r59usk02 859 10 with with IN cord-014516-r59usk02 859 11 normalization normalization NN cord-014516-r59usk02 859 12 of of IN cord-014516-r59usk02 859 13 cTSH ctsh JJ cord-014516-r59usk02 859 14 values value NNS cord-014516-r59usk02 859 15 within within IN cord-014516-r59usk02 859 16 a a DT cord-014516-r59usk02 859 17 few few JJ cord-014516-r59usk02 859 18 months month NNS cord-014516-r59usk02 859 19 . . . cord-014516-r59usk02 860 1 No no DT cord-014516-r59usk02 860 2 conflicts conflict NNS cord-014516-r59usk02 860 3 of of IN cord-014516-r59usk02 860 4 interest interest NN cord-014516-r59usk02 860 5 reported report VBN cord-014516-r59usk02 860 6 . . . cord-014516-r59usk02 861 1 Iatrogenic iatrogenic JJ cord-014516-r59usk02 861 2 hypothyroidism hypothyroidism NN cord-014516-r59usk02 861 3 is be VBZ cord-014516-r59usk02 861 4 a a DT cord-014516-r59usk02 861 5 recognized recognize VBN cord-014516-r59usk02 861 6 complication complication NN cord-014516-r59usk02 861 7 of of IN cord-014516-r59usk02 861 8 radioiodine radioiodine NN cord-014516-r59usk02 861 9 treatment treatment NN cord-014516-r59usk02 861 10 for for IN cord-014516-r59usk02 861 11 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 861 12 in in IN cord-014516-r59usk02 861 13 cats cat NNS cord-014516-r59usk02 861 14 . . . cord-014516-r59usk02 862 1 At at IN cord-014516-r59usk02 862 2 our -PRON- PRP$ cord-014516-r59usk02 862 3 clinic clinic NN cord-014516-r59usk02 862 4 where where WRB cord-014516-r59usk02 862 5 we -PRON- PRP cord-014516-r59usk02 862 6 use use VBP cord-014516-r59usk02 862 7 a a DT cord-014516-r59usk02 862 8 variable variable JJ cord-014516-r59usk02 862 9 131-I 131-i CD cord-014516-r59usk02 862 10 dosing dosing NN cord-014516-r59usk02 862 11 protocol protocol NN cord-014516-r59usk02 862 12 ( ( -LRB- cord-014516-r59usk02 862 13 based base VBN cord-014516-r59usk02 862 14 on on IN cord-014516-r59usk02 862 15 tumor tumor NN cord-014516-r59usk02 862 16 volume volume NN cord-014516-r59usk02 862 17 and and CC cord-014516-r59usk02 862 18 severity severity NN cord-014516-r59usk02 862 19 of of IN cord-014516-r59usk02 862 20 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 862 21 ) ) -RRB- cord-014516-r59usk02 862 22 , , , cord-014516-r59usk02 862 23 the the DT cord-014516-r59usk02 862 24 prevalence prevalence NN cord-014516-r59usk02 862 25 of of IN cord-014516-r59usk02 862 26 overt overt JJ cord-014516-r59usk02 862 27 or or CC cord-014516-r59usk02 862 28 subclinical subclinical JJ cord-014516-r59usk02 862 29 hypothyroidism hypothyroidism NN cord-014516-r59usk02 862 30 is be VBZ cord-014516-r59usk02 862 31 at at IN cord-014516-r59usk02 862 32 least least RBS cord-014516-r59usk02 862 33 7 7 CD cord-014516-r59usk02 862 34 % % NN cord-014516-r59usk02 862 35 . . . cord-014516-r59usk02 863 1 During during IN cord-014516-r59usk02 863 2 the the DT cord-014516-r59usk02 863 3 15-month 15-month JJ cord-014516-r59usk02 863 4 period period NN cord-014516-r59usk02 863 5 from from IN cord-014516-r59usk02 863 6 October October NNP cord-014516-r59usk02 863 7 2012 2012 CD cord-014516-r59usk02 863 8 to to IN cord-014516-r59usk02 863 9 March March NNP cord-014516-r59usk02 863 10 2014 2014 CD cord-014516-r59usk02 863 11 , , , cord-014516-r59usk02 863 12 we -PRON- PRP cord-014516-r59usk02 863 13 treated treat VBD cord-014516-r59usk02 863 14 19 19 CD cord-014516-r59usk02 863 15 cats cat NNS cord-014516-r59usk02 863 16 with with IN cord-014516-r59usk02 863 17 iatrogenic iatrogenic JJ cord-014516-r59usk02 863 18 hypothyroidism hypothyroidism NN cord-014516-r59usk02 863 19 , , , cord-014516-r59usk02 863 20 which which WDT cord-014516-r59usk02 863 21 had have VBD cord-014516-r59usk02 863 22 developed develop VBN cord-014516-r59usk02 863 23 41 41 CD cord-014516-r59usk02 863 24 - - SYM cord-014516-r59usk02 863 25 323 323 CD cord-014516-r59usk02 863 26 days day NNS cord-014516-r59usk02 863 27 ( ( -LRB- cord-014516-r59usk02 863 28 median median NN cord-014516-r59usk02 863 29 , , , cord-014516-r59usk02 863 30 119 119 CD cord-014516-r59usk02 863 31 days day NNS cord-014516-r59usk02 863 32 ) ) -RRB- cord-014516-r59usk02 863 33 after after IN cord-014516-r59usk02 863 34 treatment treatment NN cord-014516-r59usk02 863 35 with with IN cord-014516-r59usk02 863 36 radioiodine radioiodine NN cord-014516-r59usk02 863 37 ( ( -LRB- cord-014516-r59usk02 863 38 median median JJ cord-014516-r59usk02 863 39 dose dose NN cord-014516-r59usk02 863 40 , , , cord-014516-r59usk02 863 41 100 100 CD cord-014516-r59usk02 863 42 Mbq Mbq NNP cord-014516-r59usk02 863 43 ) ) -RRB- cord-014516-r59usk02 863 44 . . . cord-014516-r59usk02 864 1 These these DT cord-014516-r59usk02 864 2 cats cat NNS cord-014516-r59usk02 864 3 ranged range VBD cord-014516-r59usk02 864 4 in in IN cord-014516-r59usk02 864 5 age age NN cord-014516-r59usk02 864 6 from from IN cord-014516-r59usk02 864 7 9 9 CD cord-014516-r59usk02 864 8 - - SYM cord-014516-r59usk02 864 9 19 19 CD cord-014516-r59usk02 864 10 years year NNS cord-014516-r59usk02 864 11 ( ( -LRB- cord-014516-r59usk02 864 12 median median NN cord-014516-r59usk02 864 13 , , , cord-014516-r59usk02 864 14 14 14 CD cord-014516-r59usk02 864 15 years year NNS cord-014516-r59usk02 864 16 ) ) -RRB- cord-014516-r59usk02 864 17 ; ; : cord-014516-r59usk02 864 18 all all DT cord-014516-r59usk02 864 19 were be VBD cord-014516-r59usk02 864 20 DSH DSH NNP cord-014516-r59usk02 864 21 / / SYM cord-014516-r59usk02 864 22 DLH DLH NNP cord-014516-r59usk02 864 23 ; ; : cord-014516-r59usk02 864 24 14 14 CD cord-014516-r59usk02 864 25 ( ( -LRB- cord-014516-r59usk02 864 26 74 74 CD cord-014516-r59usk02 864 27 % % NN cord-014516-r59usk02 864 28 ) ) -RRB- cord-014516-r59usk02 864 29 were be VBD cord-014516-r59usk02 864 30 female female JJ cord-014516-r59usk02 864 31 and and CC cord-014516-r59usk02 864 32 5 5 CD cord-014516-r59usk02 864 33 were be VBD cord-014516-r59usk02 864 34 males male NNS cord-014516-r59usk02 864 35 . . . cord-014516-r59usk02 865 1 New new JJ cord-014516-r59usk02 865 2 or or CC cord-014516-r59usk02 865 3 worsening worsen VBG cord-014516-r59usk02 865 4 azotemia azotemia NN cord-014516-r59usk02 865 5 ( ( -LRB- cord-014516-r59usk02 865 6 > > NFP cord-014516-r59usk02 865 7 140 140 CD cord-014516-r59usk02 865 8 lmol lmol NNP cord-014516-r59usk02 865 9 / / SYM cord-014516-r59usk02 865 10 L L NNP cord-014516-r59usk02 865 11 ) ) -RRB- cord-014516-r59usk02 865 12 was be VBD cord-014516-r59usk02 865 13 documented document VBN cord-014516-r59usk02 865 14 in in IN cord-014516-r59usk02 865 15 16 16 CD cord-014516-r59usk02 865 16 ( ( -LRB- cord-014516-r59usk02 865 17 84 84 CD cord-014516-r59usk02 865 18 % % NN cord-014516-r59usk02 865 19 ) ) -RRB- cord-014516-r59usk02 865 20 and and CC cord-014516-r59usk02 865 21 2 2 CD cord-014516-r59usk02 865 22 ( ( -LRB- cord-014516-r59usk02 865 23 10.5 10.5 CD cord-014516-r59usk02 865 24 % % NN cord-014516-r59usk02 865 25 ) ) -RRB- cord-014516-r59usk02 865 26 cats cat NNS cord-014516-r59usk02 865 27 , , , cord-014516-r59usk02 865 28 respectively respectively RB cord-014516-r59usk02 865 29 . . . cord-014516-r59usk02 866 1 Diagnosis diagnosis NN cord-014516-r59usk02 866 2 of of IN cord-014516-r59usk02 866 3 hypothyroidism hypothyroidism NN cord-014516-r59usk02 866 4 was be VBD cord-014516-r59usk02 866 5 based base VBN cord-014516-r59usk02 866 6 on on IN cord-014516-r59usk02 866 7 the the DT cord-014516-r59usk02 866 8 following follow VBG cord-014516-r59usk02 866 9 : : : cord-014516-r59usk02 866 10 1 1 LS cord-014516-r59usk02 866 11 ) ) -RRB- cord-014516-r59usk02 866 12 low low JJ cord-014516-r59usk02 866 13 to to IN cord-014516-r59usk02 866 14 low low JJ cord-014516-r59usk02 866 15 - - HYPH cord-014516-r59usk02 866 16 normal normal JJ cord-014516-r59usk02 866 17 serum serum NN cord-014516-r59usk02 866 18 concentrations concentration NNS cord-014516-r59usk02 866 19 of of IN cord-014516-r59usk02 866 20 T4 T4 NNP cord-014516-r59usk02 866 21 , , , cord-014516-r59usk02 866 22 FT4 ft4 NN cord-014516-r59usk02 866 23 , , , cord-014516-r59usk02 866 24 and and CC cord-014516-r59usk02 866 25 T3 T3 NNP cord-014516-r59usk02 866 26 ; ; : cord-014516-r59usk02 866 27 2 2 LS cord-014516-r59usk02 866 28 ) ) -RRB- cord-014516-r59usk02 866 29 high high JJ cord-014516-r59usk02 866 30 serum serum NN cord-014516-r59usk02 866 31 TSH tsh NN cord-014516-r59usk02 866 32 concentration concentration NN cord-014516-r59usk02 866 33 ( ( -LRB- cord-014516-r59usk02 866 34 > > NFP cord-014516-r59usk02 866 35 0.5 0.5 CD cord-014516-r59usk02 866 36 ng ng NN cord-014516-r59usk02 866 37 / / SYM cord-014516-r59usk02 866 38 dl dl NN cord-014516-r59usk02 866 39 ) ) -RRB- cord-014516-r59usk02 866 40 ; ; : cord-014516-r59usk02 866 41 and and CC cord-014516-r59usk02 866 42 3 3 LS cord-014516-r59usk02 866 43 ) ) -RRB- cord-014516-r59usk02 866 44 less less JJR cord-014516-r59usk02 866 45 - - HYPH cord-014516-r59usk02 866 46 than than IN cord-014516-r59usk02 866 47 - - HYPH cord-014516-r59usk02 866 48 normal normal JJ cord-014516-r59usk02 866 49 amounts amount NNS cord-014516-r59usk02 866 50 of of IN cord-014516-r59usk02 866 51 residual residual JJ cord-014516-r59usk02 866 52 tissue tissue NN cord-014516-r59usk02 866 53 on on IN cord-014516-r59usk02 866 54 thyroid thyroid NN cord-014516-r59usk02 866 55 scintigraphy scintigraphy NN cord-014516-r59usk02 866 56 . . . cord-014516-r59usk02 867 1 All all DT cord-014516-r59usk02 867 2 cats cat NNS cord-014516-r59usk02 867 3 were be VBD cord-014516-r59usk02 867 4 given give VBN cord-014516-r59usk02 867 5 thyroid thyroid JJ cord-014516-r59usk02 867 6 hormone hormone NN cord-014516-r59usk02 867 7 replacement replacement NN cord-014516-r59usk02 867 8 as as IN cord-014516-r59usk02 867 9 a a DT cord-014516-r59usk02 867 10 liquid liquid JJ cord-014516-r59usk02 867 11 L l NN cord-014516-r59usk02 867 12 - - HYPH cord-014516-r59usk02 867 13 T4 t4 NN cord-014516-r59usk02 867 14 preparation preparation NN cord-014516-r59usk02 867 15 ( ( -LRB- cord-014516-r59usk02 867 16 Leventa Leventa NNP cord-014516-r59usk02 867 17 ; ; : cord-014516-r59usk02 867 18 Merck Merck NNP cord-014516-r59usk02 867 19 Animal Animal NNP cord-014516-r59usk02 867 20 Health Health NNP cord-014516-r59usk02 867 21 ) ) -RRB- cord-014516-r59usk02 867 22 . . . cord-014516-r59usk02 868 1 Cats cat NNS cord-014516-r59usk02 868 2 were be VBD cord-014516-r59usk02 868 3 monitored monitor VBN cord-014516-r59usk02 868 4 at at IN cord-014516-r59usk02 868 5 1 1 CD cord-014516-r59usk02 868 6 - - SYM cord-014516-r59usk02 868 7 3 3 CD cord-014516-r59usk02 868 8 month month NN cord-014516-r59usk02 868 9 intervals interval NNS cord-014516-r59usk02 868 10 by by IN cord-014516-r59usk02 868 11 repeating repeat VBG cord-014516-r59usk02 868 12 serum serum NN cord-014516-r59usk02 868 13 T4 T4 NNP cord-014516-r59usk02 868 14 and and CC cord-014516-r59usk02 868 15 TSH TSH NNP cord-014516-r59usk02 868 16 concentrations concentration NNS cord-014516-r59usk02 868 17 3 3 CD cord-014516-r59usk02 868 18 - - SYM cord-014516-r59usk02 868 19 4 4 CD cord-014516-r59usk02 868 20 hours hour NNS cord-014516-r59usk02 868 21 after after IN cord-014516-r59usk02 868 22 the the DT cord-014516-r59usk02 868 23 morning morning NN cord-014516-r59usk02 868 24 L L NNP cord-014516-r59usk02 868 25 - - HYPH cord-014516-r59usk02 868 26 T4 T4 NNP cord-014516-r59usk02 868 27 dose dose NN cord-014516-r59usk02 868 28 . . . cord-014516-r59usk02 869 1 Ten ten CD cord-014516-r59usk02 869 2 of of IN cord-014516-r59usk02 869 3 the the DT cord-014516-r59usk02 869 4 19 19 CD cord-014516-r59usk02 869 5 cats cat NNS cord-014516-r59usk02 869 6 were be VBD cord-014516-r59usk02 869 7 started start VBN cord-014516-r59usk02 869 8 on on IN cord-014516-r59usk02 869 9 a a DT cord-014516-r59usk02 869 10 once once RB cord-014516-r59usk02 869 11 - - HYPH cord-014516-r59usk02 869 12 daily daily NN cord-014516-r59usk02 869 13 L L NNP cord-014516-r59usk02 869 14 - - HYPH cord-014516-r59usk02 869 15 T4 T4 NNP cord-014516-r59usk02 869 16 regimen regimen NN cord-014516-r59usk02 869 17 ( ( -LRB- cord-014516-r59usk02 869 18 100 100 CD cord-014516-r59usk02 869 19 lg lg NNP cord-014516-r59usk02 869 20 ) ) -RRB- cord-014516-r59usk02 869 21 ; ; : cord-014516-r59usk02 869 22 of of IN cord-014516-r59usk02 869 23 these these DT cord-014516-r59usk02 869 24 , , , cord-014516-r59usk02 869 25 only only RB cord-014516-r59usk02 869 26 2 2 CD cord-014516-r59usk02 869 27 ( ( -LRB- cord-014516-r59usk02 869 28 20 20 CD cord-014516-r59usk02 869 29 % % NN cord-014516-r59usk02 869 30 ) ) -RRB- cord-014516-r59usk02 869 31 had have VBD cord-014516-r59usk02 869 32 suppression suppression NN cord-014516-r59usk02 869 33 of of IN cord-014516-r59usk02 869 34 high high JJ cord-014516-r59usk02 869 35 serum serum NN cord-014516-r59usk02 869 36 TSH tsh NN cord-014516-r59usk02 869 37 values value NNS cord-014516-r59usk02 869 38 into into IN cord-014516-r59usk02 869 39 the the DT cord-014516-r59usk02 869 40 reference reference NN cord-014516-r59usk02 869 41 interval interval NN cord-014516-r59usk02 869 42 ( ( -LRB- cord-014516-r59usk02 869 43 RI RI NNP cord-014516-r59usk02 869 44 ) ) -RRB- cord-014516-r59usk02 869 45 . . . cord-014516-r59usk02 870 1 Of of IN cord-014516-r59usk02 870 2 the the DT cord-014516-r59usk02 870 3 8 8 CD cord-014516-r59usk02 870 4 cats cat NNS cord-014516-r59usk02 870 5 that that WDT cord-014516-r59usk02 870 6 had have VBD cord-014516-r59usk02 870 7 persistently persistently RB cord-014516-r59usk02 870 8 high high JJ cord-014516-r59usk02 870 9 TSH tsh NN cord-014516-r59usk02 870 10 values value NNS cord-014516-r59usk02 870 11 , , , cord-014516-r59usk02 870 12 5 5 CD cord-014516-r59usk02 870 13 were be VBD cord-014516-r59usk02 870 14 switched switch VBN cord-014516-r59usk02 870 15 to to IN cord-014516-r59usk02 870 16 twice twice RB cord-014516-r59usk02 870 17 - - HYPH cord-014516-r59usk02 870 18 daily daily JJ cord-014516-r59usk02 870 19 administration administration NN cord-014516-r59usk02 870 20 ( ( -LRB- cord-014516-r59usk02 870 21 75 75 CD cord-014516-r59usk02 870 22 - - SYM cord-014516-r59usk02 870 23 100 100 CD cord-014516-r59usk02 870 24 lg lg NNS cord-014516-r59usk02 870 25 , , , cord-014516-r59usk02 870 26 BID BID NNP cord-014516-r59usk02 870 27 ) ) -RRB- cord-014516-r59usk02 870 28 , , , cord-014516-r59usk02 870 29 which which WDT cord-014516-r59usk02 870 30 successfully successfully RB cord-014516-r59usk02 870 31 lowered lower VBD cord-014516-r59usk02 870 32 high high JJ cord-014516-r59usk02 870 33 TSH TSH NNP cord-014516-r59usk02 870 34 concentrations concentration NNS cord-014516-r59usk02 870 35 in in IN cord-014516-r59usk02 870 36 4 4 CD cord-014516-r59usk02 870 37 cats cat NNS cord-014516-r59usk02 870 38 . . . cord-014516-r59usk02 871 1 The the DT cord-014516-r59usk02 871 2 remaining remain VBG cord-014516-r59usk02 871 3 9 9 CD cord-014516-r59usk02 871 4 cats cat NNS cord-014516-r59usk02 871 5 were be VBD cord-014516-r59usk02 871 6 started start VBN cord-014516-r59usk02 871 7 on on IN cord-014516-r59usk02 871 8 twice twice JJ cord-014516-r59usk02 871 9 daily daily JJ cord-014516-r59usk02 871 10 L L NNP cord-014516-r59usk02 871 11 - - HYPH cord-014516-r59usk02 871 12 T4 T4 NNP cord-014516-r59usk02 871 13 ( ( -LRB- cord-014516-r59usk02 871 14 75 75 CD cord-014516-r59usk02 871 15 lg lg NNP cord-014516-r59usk02 871 16 , , , cord-014516-r59usk02 871 17 BID BID NNP cord-014516-r59usk02 871 18 ) ) -RRB- cord-014516-r59usk02 871 19 ; ; : cord-014516-r59usk02 871 20 of of IN cord-014516-r59usk02 871 21 these these DT cord-014516-r59usk02 871 22 , , , cord-014516-r59usk02 871 23 normalization normalization NN cord-014516-r59usk02 871 24 of of IN cord-014516-r59usk02 871 25 TSH tsh NN cord-014516-r59usk02 871 26 occurred occur VBD cord-014516-r59usk02 871 27 in in IN cord-014516-r59usk02 871 28 5 5 CD cord-014516-r59usk02 871 29 cats cat NNS cord-014516-r59usk02 871 30 . . . cord-014516-r59usk02 872 1 Overall overall RB cord-014516-r59usk02 872 2 , , , cord-014516-r59usk02 872 3 L L NNP cord-014516-r59usk02 872 4 - - HYPH cord-014516-r59usk02 872 5 T4 T4 NNP cord-014516-r59usk02 872 6 treatment treatment NN cord-014516-r59usk02 872 7 was be VBD cord-014516-r59usk02 872 8 successful successful JJ cord-014516-r59usk02 872 9 in in IN cord-014516-r59usk02 872 10 normalizing normalize VBG cord-014516-r59usk02 872 11 TSH TSH NNP cord-014516-r59usk02 872 12 concentrations concentration NNS cord-014516-r59usk02 872 13 in in IN cord-014516-r59usk02 872 14 11 11 CD cord-014516-r59usk02 872 15 ( ( -LRB- cord-014516-r59usk02 872 16 58 58 CD cord-014516-r59usk02 872 17 % % NN cord-014516-r59usk02 872 18 ) ) -RRB- cord-014516-r59usk02 872 19 cats cat NNS cord-014516-r59usk02 872 20 , , , cord-014516-r59usk02 872 21 2 2 CD cord-014516-r59usk02 872 22 with with IN cord-014516-r59usk02 872 23 once once RB cord-014516-r59usk02 872 24 - - HYPH cord-014516-r59usk02 872 25 daily daily NN cord-014516-r59usk02 872 26 and and CC cord-014516-r59usk02 872 27 9 9 CD cord-014516-r59usk02 872 28 with with IN cord-014516-r59usk02 872 29 twice twice RB cord-014516-r59usk02 872 30 - - HYPH cord-014516-r59usk02 872 31 daily daily NN cord-014516-r59usk02 872 32 dosing dosing NN cord-014516-r59usk02 872 33 . . . cord-014516-r59usk02 873 1 Peak Peak NNP cord-014516-r59usk02 873 2 serum serum NN cord-014516-r59usk02 873 3 T4 T4 NNP cord-014516-r59usk02 873 4 concentrations concentration NNS cord-014516-r59usk02 873 5 of of IN cord-014516-r59usk02 873 6 ≥30 ≥30 JJ cord-014516-r59usk02 873 7 nmol nmol NNP cord-014516-r59usk02 873 8 / / SYM cord-014516-r59usk02 873 9 L L NNP cord-014516-r59usk02 873 10 were be VBD cord-014516-r59usk02 873 11 needed need VBN cord-014516-r59usk02 873 12 in in IN cord-014516-r59usk02 873 13 most most JJS cord-014516-r59usk02 873 14 cats cat NNS cord-014516-r59usk02 873 15 to to TO cord-014516-r59usk02 873 16 normalize normalize VB cord-014516-r59usk02 873 17 TSH tsh NN cord-014516-r59usk02 873 18 values value NNS cord-014516-r59usk02 873 19 . . . cord-014516-r59usk02 874 1 Higher high JJR cord-014516-r59usk02 874 2 serum serum NN cord-014516-r59usk02 874 3 T4 t4 NN cord-014516-r59usk02 874 4 and and CC cord-014516-r59usk02 874 5 lower low JJR cord-014516-r59usk02 874 6 TSH TSH NNP cord-014516-r59usk02 874 7 concentrations concentration NNS cord-014516-r59usk02 874 8 were be VBD cord-014516-r59usk02 874 9 achieved achieve VBN cord-014516-r59usk02 874 10 when when WRB cord-014516-r59usk02 874 11 L L NNP cord-014516-r59usk02 874 12 - - HYPH cord-014516-r59usk02 874 13 T4 T4 NNP cord-014516-r59usk02 874 14 was be VBD cord-014516-r59usk02 874 15 administered administer VBN cord-014516-r59usk02 874 16 on on IN cord-014516-r59usk02 874 17 an an DT cord-014516-r59usk02 874 18 empty empty JJ cord-014516-r59usk02 874 19 stomach stomach NN cord-014516-r59usk02 874 20 rather rather RB cord-014516-r59usk02 874 21 than than IN cord-014516-r59usk02 874 22 given give VBN cord-014516-r59usk02 874 23 with with IN cord-014516-r59usk02 874 24 food food NN cord-014516-r59usk02 874 25 . . . cord-014516-r59usk02 875 1 A a DT cord-014516-r59usk02 875 2 significant significant JJ cord-014516-r59usk02 875 3 decrease decrease NN cord-014516-r59usk02 875 4 ( ( -LRB- cord-014516-r59usk02 875 5 P p NN cord-014516-r59usk02 875 6 < < XX cord-014516-r59usk02 875 7 0.003 0.003 CD cord-014516-r59usk02 875 8 ) ) -RRB- cord-014516-r59usk02 875 9 in in IN cord-014516-r59usk02 875 10 serum serum NN cord-014516-r59usk02 875 11 creatinine creatinine NN cord-014516-r59usk02 875 12 occurred occur VBD cord-014516-r59usk02 875 13 after after IN cord-014516-r59usk02 875 14 treatment treatment NN cord-014516-r59usk02 875 15 with with IN cord-014516-r59usk02 875 16 L L NNP cord-014516-r59usk02 875 17 - - HYPH cord-014516-r59usk02 875 18 T4 T4 NNP cord-014516-r59usk02 875 19 . . . cord-014516-r59usk02 876 1 In in IN cord-014516-r59usk02 876 2 conclusion conclusion NN cord-014516-r59usk02 876 3 , , , cord-014516-r59usk02 876 4 our -PRON- PRP$ cord-014516-r59usk02 876 5 results result NNS cord-014516-r59usk02 876 6 indicate indicate VBP cord-014516-r59usk02 876 7 that that IN cord-014516-r59usk02 876 8 twice twice RB cord-014516-r59usk02 876 9 - - HYPH cord-014516-r59usk02 876 10 daily daily JJ cord-014516-r59usk02 876 11 administration administration NN cord-014516-r59usk02 876 12 of of IN cord-014516-r59usk02 876 13 L L NNP cord-014516-r59usk02 876 14 - - HYPH cord-014516-r59usk02 876 15 T4 T4 NNP cord-014516-r59usk02 876 16 is be VBZ cord-014516-r59usk02 876 17 needed need VBN cord-014516-r59usk02 876 18 in in IN cord-014516-r59usk02 876 19 most most JJS cord-014516-r59usk02 876 20 cats cat NNS cord-014516-r59usk02 876 21 with with IN cord-014516-r59usk02 876 22 iatrogenic iatrogenic JJ cord-014516-r59usk02 876 23 hypothyroidism hypothyroidism NN cord-014516-r59usk02 876 24 to to TO cord-014516-r59usk02 876 25 normalize normalize VB cord-014516-r59usk02 876 26 high high JJ cord-014516-r59usk02 876 27 serum serum NN cord-014516-r59usk02 876 28 TSH tsh NN cord-014516-r59usk02 876 29 concentrations concentration NNS cord-014516-r59usk02 876 30 . . . cord-014516-r59usk02 877 1 Many many JJ cord-014516-r59usk02 877 2 cats cat NNS cord-014516-r59usk02 877 3 appear appear VBP cord-014516-r59usk02 877 4 to to TO cord-014516-r59usk02 877 5 absorb absorb VB cord-014516-r59usk02 877 6 L L NNP cord-014516-r59usk02 877 7 - - HYPH cord-014516-r59usk02 877 8 T4 T4 NNP cord-014516-r59usk02 877 9 rather rather RB cord-014516-r59usk02 877 10 poorly poorly RB cord-014516-r59usk02 877 11 , , , cord-014516-r59usk02 877 12 which which WDT cord-014516-r59usk02 877 13 can can MD cord-014516-r59usk02 877 14 be be VB cord-014516-r59usk02 877 15 enhanced enhance VBN cord-014516-r59usk02 877 16 by by IN cord-014516-r59usk02 877 17 giving give VBG cord-014516-r59usk02 877 18 the the DT cord-014516-r59usk02 877 19 drug drug NN cord-014516-r59usk02 877 20 on on IN cord-014516-r59usk02 877 21 an an DT cord-014516-r59usk02 877 22 empty empty JJ cord-014516-r59usk02 877 23 stomach stomach NN cord-014516-r59usk02 877 24 . . . cord-014516-r59usk02 878 1 The the DT cord-014516-r59usk02 878 2 azotemia azotemia NN cord-014516-r59usk02 878 3 that that WDT cord-014516-r59usk02 878 4 commonly commonly RB cord-014516-r59usk02 878 5 develops develop VBZ cord-014516-r59usk02 878 6 in in IN cord-014516-r59usk02 878 7 cats cat NNS cord-014516-r59usk02 878 8 with with IN cord-014516-r59usk02 878 9 hypothyroidism hypothyroidism NN cord-014516-r59usk02 878 10 improved improve VBN cord-014516-r59usk02 878 11 or or CC cord-014516-r59usk02 878 12 stabilized stabilize VBN cord-014516-r59usk02 878 13 with with IN cord-014516-r59usk02 878 14 adequate adequate JJ cord-014516-r59usk02 878 15 L L NNP cord-014516-r59usk02 878 16 - - HYPH cord-014516-r59usk02 878 17 T4 T4 NNP cord-014516-r59usk02 878 18 supplementation supplementation NN cord-014516-r59usk02 878 19 . . . cord-014516-r59usk02 879 1 No no DT cord-014516-r59usk02 879 2 conflicts conflict NNS cord-014516-r59usk02 879 3 of of IN cord-014516-r59usk02 879 4 interest interest NN cord-014516-r59usk02 879 5 reported report VBN cord-014516-r59usk02 879 6 . . . cord-014516-r59usk02 880 1 Congenital congenital JJ cord-014516-r59usk02 880 2 hypothyroidism hypothyroidism NN cord-014516-r59usk02 880 3 ( ( -LRB- cord-014516-r59usk02 880 4 CH CH NNP cord-014516-r59usk02 880 5 ) ) -RRB- cord-014516-r59usk02 880 6 has have VBZ cord-014516-r59usk02 880 7 been be VBN cord-014516-r59usk02 880 8 reported report VBN cord-014516-r59usk02 880 9 in in IN cord-014516-r59usk02 880 10 many many JJ cord-014516-r59usk02 880 11 species specie NNS cord-014516-r59usk02 880 12 ; ; : cord-014516-r59usk02 880 13 the the DT cord-014516-r59usk02 880 14 hereditary hereditary JJ cord-014516-r59usk02 880 15 forms form NNS cord-014516-r59usk02 880 16 can can MD cord-014516-r59usk02 880 17 be be VB cord-014516-r59usk02 880 18 divided divide VBN cord-014516-r59usk02 880 19 into into IN cord-014516-r59usk02 880 20 thyroid thyroid NN cord-014516-r59usk02 880 21 dysmorphogenesis dysmorphogenesis NN cord-014516-r59usk02 880 22 and and CC cord-014516-r59usk02 880 23 dyshormonogenesis dyshormonogenesis NNP cord-014516-r59usk02 880 24 . . . cord-014516-r59usk02 881 1 While while IN cord-014516-r59usk02 881 2 thyroid thyroid JJ cord-014516-r59usk02 881 3 hypoplasia hypoplasia NN cord-014516-r59usk02 881 4 has have VBZ cord-014516-r59usk02 881 5 been be VBN cord-014516-r59usk02 881 6 described describe VBN cord-014516-r59usk02 881 7 in in IN cord-014516-r59usk02 881 8 dogs dog NNS cord-014516-r59usk02 881 9 and and CC cord-014516-r59usk02 881 10 cats cat NNS cord-014516-r59usk02 881 11 , , , cord-014516-r59usk02 881 12 the the DT cord-014516-r59usk02 881 13 molecular molecular JJ cord-014516-r59usk02 881 14 basis basis NN cord-014516-r59usk02 881 15 remains remain VBZ cord-014516-r59usk02 881 16 unknown unknown JJ cord-014516-r59usk02 881 17 . . . cord-014516-r59usk02 882 1 In in IN cord-014516-r59usk02 882 2 contrast contrast JJ cord-014516-r59usk02 882 3 few few JJ cord-014516-r59usk02 882 4 breeds breed NNS cord-014516-r59usk02 882 5 of of IN cord-014516-r59usk02 882 6 dogs dog NNS cord-014516-r59usk02 882 7 with with IN cord-014516-r59usk02 882 8 goiterous goiterous NNP cord-014516-r59usk02 882 9 CH CH NNP cord-014516-r59usk02 882 10 were be VBD cord-014516-r59usk02 882 11 found find VBN cord-014516-r59usk02 882 12 to to TO cord-014516-r59usk02 882 13 have have VB cord-014516-r59usk02 882 14 deficient deficient JJ cord-014516-r59usk02 882 15 thyroid thyroid NN cord-014516-r59usk02 882 16 peroxidase peroxidase NN cord-014516-r59usk02 882 17 ( ( -LRB- cord-014516-r59usk02 882 18 TPO TPO NNP cord-014516-r59usk02 882 19 ) ) -RRB- cord-014516-r59usk02 882 20 activity activity NN cord-014516-r59usk02 882 21 . . . cord-014516-r59usk02 883 1 The the DT cord-014516-r59usk02 883 2 purpose purpose NN cord-014516-r59usk02 883 3 of of IN cord-014516-r59usk02 883 4 our -PRON- PRP$ cord-014516-r59usk02 883 5 study study NN cord-014516-r59usk02 883 6 was be VBD cord-014516-r59usk02 883 7 to to TO cord-014516-r59usk02 883 8 characterize characterize VB cord-014516-r59usk02 883 9 a a DT cord-014516-r59usk02 883 10 family family NN cord-014516-r59usk02 883 11 of of IN cord-014516-r59usk02 883 12 domestic domestic JJ cord-014516-r59usk02 883 13 shorthair shorthair JJ cord-014516-r59usk02 883 14 cats cat NNS cord-014516-r59usk02 883 15 with with IN cord-014516-r59usk02 883 16 goiterous goiterous NNP cord-014516-r59usk02 883 17 CH CH NNP cord-014516-r59usk02 883 18 and and CC cord-014516-r59usk02 883 19 disease disease NN cord-014516-r59usk02 883 20 - - HYPH cord-014516-r59usk02 883 21 causing cause VBG cord-014516-r59usk02 883 22 TPO TPO NNP cord-014516-r59usk02 883 23 gene gene NN cord-014516-r59usk02 883 24 mutations mutation NNS cord-014516-r59usk02 883 25 . . . cord-014516-r59usk02 884 1 Clinical clinical JJ cord-014516-r59usk02 884 2 features feature NNS cord-014516-r59usk02 884 3 included include VBD cord-014516-r59usk02 884 4 dwarfism dwarfism NN cord-014516-r59usk02 884 5 and and CC cord-014516-r59usk02 884 6 dullness dullness NN cord-014516-r59usk02 884 7 , , , cord-014516-r59usk02 884 8 known know VBN cord-014516-r59usk02 884 9 as as IN cord-014516-r59usk02 884 10 cretinism cretinism NN cord-014516-r59usk02 884 11 and and CC cord-014516-r59usk02 884 12 seen see VBN cord-014516-r59usk02 884 13 with with IN cord-014516-r59usk02 884 14 CH CH NNP cord-014516-r59usk02 884 15 in in IN cord-014516-r59usk02 884 16 all all DT cord-014516-r59usk02 884 17 species specie NNS cord-014516-r59usk02 884 18 , , , cord-014516-r59usk02 884 19 but but CC cord-014516-r59usk02 884 20 also also RB cord-014516-r59usk02 884 21 constipation constipation NN cord-014516-r59usk02 884 22 and and CC cord-014516-r59usk02 884 23 megacolon megacolon NN cord-014516-r59usk02 884 24 which which WDT cord-014516-r59usk02 884 25 are be VBP cord-014516-r59usk02 884 26 unique unique JJ cord-014516-r59usk02 884 27 to to IN cord-014516-r59usk02 884 28 cats cat NNS cord-014516-r59usk02 884 29 with with IN cord-014516-r59usk02 884 30 CH CH NNP cord-014516-r59usk02 884 31 . . . cord-014516-r59usk02 885 1 Pedigree pedigree NN cord-014516-r59usk02 885 2 analysis analysis NN cord-014516-r59usk02 885 3 documented document VBD cord-014516-r59usk02 885 4 an an DT cord-014516-r59usk02 885 5 autosomal autosomal JJ cord-014516-r59usk02 885 6 recessive recessive JJ cord-014516-r59usk02 885 7 mode mode NN cord-014516-r59usk02 885 8 of of IN cord-014516-r59usk02 885 9 inheritance inheritance NN cord-014516-r59usk02 885 10 . . . cord-014516-r59usk02 886 1 Affected affected JJ cord-014516-r59usk02 886 2 kittens kitten NNS cord-014516-r59usk02 886 3 developed develop VBD cord-014516-r59usk02 886 4 a a DT cord-014516-r59usk02 886 5 goiter goiter NN cord-014516-r59usk02 886 6 and and CC cord-014516-r59usk02 886 7 had have VBD cord-014516-r59usk02 886 8 low low JJ cord-014516-r59usk02 886 9 serum serum NN cord-014516-r59usk02 886 10 thyroxine thyroxine NN cord-014516-r59usk02 886 11 ( ( -LRB- cord-014516-r59usk02 886 12 T4 T4 NNP cord-014516-r59usk02 886 13 ) ) -RRB- cord-014516-r59usk02 886 14 and and CC cord-014516-r59usk02 886 15 triiodothyronine triiodothyronine NNP cord-014516-r59usk02 886 16 ( ( -LRB- cord-014516-r59usk02 886 17 T3 T3 NNP cord-014516-r59usk02 886 18 ) ) -RRB- cord-014516-r59usk02 886 19 when when WRB cord-014516-r59usk02 886 20 compared compare VBN cord-014516-r59usk02 886 21 to to IN cord-014516-r59usk02 886 22 controls control NNS cord-014516-r59usk02 886 23 , , , cord-014516-r59usk02 886 24 but but CC cord-014516-r59usk02 886 25 high high JJ cord-014516-r59usk02 886 26 thyroid thyroid NN cord-014516-r59usk02 886 27 stimulating stimulate VBG cord-014516-r59usk02 886 28 ( ( -LRB- cord-014516-r59usk02 886 29 TSH TSH NNP cord-014516-r59usk02 886 30 ) ) -RRB- cord-014516-r59usk02 886 31 hormone hormone NN cord-014516-r59usk02 886 32 levels level NNS cord-014516-r59usk02 886 33 indicating indicate VBG cord-014516-r59usk02 886 34 thyroid thyroid NN cord-014516-r59usk02 886 35 dyshormonogenesis dyshormonogenesis NN cord-014516-r59usk02 886 36 . . . cord-014516-r59usk02 887 1 Oral oral JJ cord-014516-r59usk02 887 2 thyroid thyroid NN cord-014516-r59usk02 887 3 supplementation supplementation NN cord-014516-r59usk02 887 4 corrected correct VBD cord-014516-r59usk02 887 5 the the DT cord-014516-r59usk02 887 6 progression progression NN cord-014516-r59usk02 887 7 of of IN cord-014516-r59usk02 887 8 clinical clinical JJ cord-014516-r59usk02 887 9 signs sign NNS cord-014516-r59usk02 887 10 and and CC cord-014516-r59usk02 887 11 prevented prevent VBN cord-014516-r59usk02 887 12 further further JJ cord-014516-r59usk02 887 13 constipation constipation NN cord-014516-r59usk02 887 14 and and CC cord-014516-r59usk02 887 15 reversed reverse VBD cord-014516-r59usk02 887 16 the the DT cord-014516-r59usk02 887 17 megacolon megacolon NN cord-014516-r59usk02 887 18 . . . cord-014516-r59usk02 888 1 The the DT cord-014516-r59usk02 888 2 TPO TPO NNP cord-014516-r59usk02 888 3 enzyme enzyme NN cord-014516-r59usk02 888 4 activity activity NN cord-014516-r59usk02 888 5 was be VBD cord-014516-r59usk02 888 6 extremely extremely RB cord-014516-r59usk02 888 7 low low JJ cord-014516-r59usk02 888 8 in in IN cord-014516-r59usk02 888 9 hypothyroid hypothyroid JJ cord-014516-r59usk02 888 10 cats cat NNS cord-014516-r59usk02 888 11 when when WRB cord-014516-r59usk02 888 12 compared compare VBN cord-014516-r59usk02 888 13 to to IN cord-014516-r59usk02 888 14 that that DT cord-014516-r59usk02 888 15 of of IN cord-014516-r59usk02 888 16 normal normal JJ cord-014516-r59usk02 888 17 cats cat NNS cord-014516-r59usk02 888 18 . . . cord-014516-r59usk02 889 1 Genomic genomic JJ cord-014516-r59usk02 889 2 DNA dna NN cord-014516-r59usk02 889 3 and and CC cord-014516-r59usk02 889 4 cDNA cdna NN cord-014516-r59usk02 889 5 from from IN cord-014516-r59usk02 889 6 affected affect VBN cord-014516-r59usk02 889 7 , , , cord-014516-r59usk02 889 8 carrier carrier NN cord-014516-r59usk02 889 9 , , , cord-014516-r59usk02 889 10 and and CC cord-014516-r59usk02 889 11 normal normal JJ cord-014516-r59usk02 889 12 cats cat NNS cord-014516-r59usk02 889 13 were be VBD cord-014516-r59usk02 889 14 extracted extract VBN cord-014516-r59usk02 889 15 and and CC cord-014516-r59usk02 889 16 sequenced sequence VBN cord-014516-r59usk02 889 17 based base VBN cord-014516-r59usk02 889 18 upon upon IN cord-014516-r59usk02 889 19 primers primer NNS cord-014516-r59usk02 889 20 developed develop VBN cord-014516-r59usk02 889 21 from from IN cord-014516-r59usk02 889 22 the the DT cord-014516-r59usk02 889 23 feline feline JJ cord-014516-r59usk02 889 24 genome genome NN cord-014516-r59usk02 889 25 database database NN cord-014516-r59usk02 889 26 . . . cord-014516-r59usk02 890 1 A a DT cord-014516-r59usk02 890 2 homozygous homozygous JJ cord-014516-r59usk02 890 3 missense missense NN cord-014516-r59usk02 890 4 point point NN cord-014516-r59usk02 890 5 mutation mutation NN cord-014516-r59usk02 890 6 ( ( -LRB- cord-014516-r59usk02 890 7 c.1333 c.1333 NNP cord-014516-r59usk02 890 8 G g NN cord-014516-r59usk02 891 1 > > XX cord-014516-r59usk02 891 2 A a LS cord-014516-r59usk02 891 3 ) ) -RRB- cord-014516-r59usk02 891 4 in in IN cord-014516-r59usk02 891 5 TPO TPO NNP cord-014516-r59usk02 891 6 , , , cord-014516-r59usk02 891 7 which which WDT cord-014516-r59usk02 891 8 results result VBZ cord-014516-r59usk02 891 9 in in IN cord-014516-r59usk02 891 10 an an DT cord-014516-r59usk02 891 11 amino amino NN cord-014516-r59usk02 891 12 acid acid NN cord-014516-r59usk02 891 13 change change NN cord-014516-r59usk02 891 14 ( ( -LRB- cord-014516-r59usk02 891 15 p p NN cord-014516-r59usk02 891 16 . . . cord-014516-r59usk02 891 17 Ala445Thr Ala445Thr NNP cord-014516-r59usk02 891 18 ) ) -RRB- cord-014516-r59usk02 891 19 , , , cord-014516-r59usk02 891 20 was be VBD cord-014516-r59usk02 891 21 discovered discover VBN cord-014516-r59usk02 891 22 in in IN cord-014516-r59usk02 891 23 affected affected JJ cord-014516-r59usk02 891 24 cats cat NNS cord-014516-r59usk02 891 25 and and CC cord-014516-r59usk02 891 26 the the DT cord-014516-r59usk02 891 27 mutant mutant JJ cord-014516-r59usk02 891 28 allele allele NN cord-014516-r59usk02 891 29 segregated segregate VBN cord-014516-r59usk02 891 30 within within IN cord-014516-r59usk02 891 31 the the DT cord-014516-r59usk02 891 32 family family NN cord-014516-r59usk02 891 33 with with IN cord-014516-r59usk02 891 34 goiterous goiterous NNP cord-014516-r59usk02 891 35 CH CH NNP cord-014516-r59usk02 891 36 . . . cord-014516-r59usk02 892 1 This this DT cord-014516-r59usk02 892 2 is be VBZ cord-014516-r59usk02 892 3 the the DT cord-014516-r59usk02 892 4 first first JJ cord-014516-r59usk02 892 5 report report NN cord-014516-r59usk02 892 6 of of IN cord-014516-r59usk02 892 7 a a DT cord-014516-r59usk02 892 8 TPO TPO NNP cord-014516-r59usk02 892 9 deficiency deficiency NN cord-014516-r59usk02 892 10 in in IN cord-014516-r59usk02 892 11 cats cat NNS cord-014516-r59usk02 892 12 . . . cord-014516-r59usk02 893 1 Other other JJ cord-014516-r59usk02 893 2 unrelated unrelated JJ cord-014516-r59usk02 893 3 domestic domestic JJ cord-014516-r59usk02 893 4 shorthair shorthair JJ cord-014516-r59usk02 893 5 cats cat NNS cord-014516-r59usk02 893 6 with with IN cord-014516-r59usk02 893 7 goiterous goiterous NNP cord-014516-r59usk02 893 8 CH CH NNP cord-014516-r59usk02 893 9 did do VBD cord-014516-r59usk02 893 10 not not RB cord-014516-r59usk02 893 11 have have VB cord-014516-r59usk02 893 12 this this DT cord-014516-r59usk02 893 13 same same JJ cord-014516-r59usk02 893 14 TPO TPO NNP cord-014516-r59usk02 893 15 mutation mutation NN cord-014516-r59usk02 893 16 . . . cord-014516-r59usk02 894 1 The the DT cord-014516-r59usk02 894 2 prevalence prevalence NN cord-014516-r59usk02 894 3 of of IN cord-014516-r59usk02 894 4 this this DT cord-014516-r59usk02 894 5 TPO TPO NNP cord-014516-r59usk02 894 6 mutation mutation NN cord-014516-r59usk02 894 7 in in IN cord-014516-r59usk02 894 8 the the DT cord-014516-r59usk02 894 9 domestic domestic JJ cord-014516-r59usk02 894 10 cat cat NN cord-014516-r59usk02 894 11 population population NN cord-014516-r59usk02 894 12 seems seem VBZ cord-014516-r59usk02 894 13 low low JJ cord-014516-r59usk02 894 14 , , , cord-014516-r59usk02 894 15 but but CC cord-014516-r59usk02 894 16 CH CH NNP cord-014516-r59usk02 894 17 is be VBZ cord-014516-r59usk02 894 18 likely likely RB cord-014516-r59usk02 894 19 underreported underreporte VBN cord-014516-r59usk02 894 20 in in IN cord-014516-r59usk02 894 21 cats cat NNS cord-014516-r59usk02 894 22 . . . cord-014516-r59usk02 895 1 Supported support VBN cord-014516-r59usk02 895 2 in in IN cord-014516-r59usk02 895 3 part part NN cord-014516-r59usk02 895 4 by by IN cord-014516-r59usk02 895 5 NIH NIH NNP cord-014516-r59usk02 895 6 OD OD NNP cord-014516-r59usk02 895 7 010939 010939 CD cord-014516-r59usk02 895 8 . . . cord-014516-r59usk02 896 1 Some some DT cord-014516-r59usk02 896 2 of of IN cord-014516-r59usk02 896 3 the the DT cord-014516-r59usk02 896 4 authors author NNS cord-014516-r59usk02 896 5 are be VBP cord-014516-r59usk02 896 6 members member NNS cord-014516-r59usk02 896 7 of of IN cord-014516-r59usk02 896 8 diagnostic diagnostic JJ cord-014516-r59usk02 896 9 laboratories laboratory NNS cord-014516-r59usk02 896 10 ( ( -LRB- cord-014516-r59usk02 896 11 PennGen PennGen NNP cord-014516-r59usk02 896 12 ) ) -RRB- cord-014516-r59usk02 896 13 . . . cord-014516-r59usk02 897 1 Supported support VBN cord-014516-r59usk02 897 2 in in IN cord-014516-r59usk02 897 3 part part NN cord-014516-r59usk02 897 4 by by IN cord-014516-r59usk02 897 5 the the DT cord-014516-r59usk02 897 6 NIH NIH NNP cord-014516-r59usk02 897 7 OD OD NNP cord-014516-r59usk02 898 1 # # $ cord-014516-r59usk02 898 2 010939 010939 CD cord-014516-r59usk02 898 3 . . . cord-014516-r59usk02 899 1 Glucagon Glucagon NNP cord-014516-r59usk02 899 2 - - HYPH cord-014516-r59usk02 899 3 like like IN cord-014516-r59usk02 899 4 peptide-1 peptide-1 NNP cord-014516-r59usk02 900 1 ( ( -LRB- cord-014516-r59usk02 900 2 GLP-1)is glp-1)i VBG cord-014516-r59usk02 900 3 a a DT cord-014516-r59usk02 900 4 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 900 5 hormone hormone NN cord-014516-r59usk02 900 6 released release VBN cord-014516-r59usk02 900 7 in in IN cord-014516-r59usk02 900 8 response response NN cord-014516-r59usk02 900 9 to to IN cord-014516-r59usk02 900 10 food food NN cord-014516-r59usk02 900 11 intake intake NN cord-014516-r59usk02 900 12 that that WDT cord-014516-r59usk02 900 13 increases increase VBZ cord-014516-r59usk02 900 14 insulin insulin NN cord-014516-r59usk02 900 15 secretion secretion NN cord-014516-r59usk02 900 16 , , , cord-014516-r59usk02 900 17 inhibits inhibit VBZ cord-014516-r59usk02 900 18 glucagon glucagon NN cord-014516-r59usk02 900 19 secretion secretion NN cord-014516-r59usk02 900 20 , , , cord-014516-r59usk02 900 21 slows slow VBZ cord-014516-r59usk02 900 22 gastric gastric JJ cord-014516-r59usk02 900 23 emptying emptying NN cord-014516-r59usk02 900 24 and and CC cord-014516-r59usk02 900 25 induces induce VBZ cord-014516-r59usk02 900 26 satiation satiation NN cord-014516-r59usk02 900 27 . . . cord-014516-r59usk02 901 1 It -PRON- PRP cord-014516-r59usk02 901 2 is be VBZ cord-014516-r59usk02 901 3 also also RB cord-014516-r59usk02 901 4 assumed assume VBN cord-014516-r59usk02 901 5 to to TO cord-014516-r59usk02 901 6 stimulate stimulate VB cord-014516-r59usk02 901 7 beta beta NN cord-014516-r59usk02 901 8 - - HYPH cord-014516-r59usk02 901 9 cell cell NN cord-014516-r59usk02 901 10 proliferation proliferation NN cord-014516-r59usk02 901 11 . . . cord-014516-r59usk02 902 1 GLP-1 glp-1 JJ cord-014516-r59usk02 902 2 agonists agonist NNS cord-014516-r59usk02 902 3 are be VBP cord-014516-r59usk02 902 4 successfully successfully RB cord-014516-r59usk02 902 5 used use VBN cord-014516-r59usk02 902 6 in in IN cord-014516-r59usk02 902 7 humans human NNS cord-014516-r59usk02 902 8 with with IN cord-014516-r59usk02 902 9 type type NN cord-014516-r59usk02 902 10 2 2 CD cord-014516-r59usk02 902 11 diabetes diabetes NN cord-014516-r59usk02 902 12 mellitus mellitus NN cord-014516-r59usk02 902 13 usually usually RB cord-014516-r59usk02 902 14 either either CC cord-014516-r59usk02 902 15 in in IN cord-014516-r59usk02 902 16 combination combination NN cord-014516-r59usk02 902 17 with with IN cord-014516-r59usk02 902 18 insulin insulin NN cord-014516-r59usk02 902 19 or or CC cord-014516-r59usk02 902 20 other other JJ cord-014516-r59usk02 902 21 anti anti JJ cord-014516-r59usk02 902 22 - - JJ cord-014516-r59usk02 902 23 diabetic diabetic JJ cord-014516-r59usk02 902 24 drugs drug NNS cord-014516-r59usk02 902 25 . . . cord-014516-r59usk02 903 1 In in IN cord-014516-r59usk02 903 2 healthy healthy JJ cord-014516-r59usk02 903 3 cats cat NNS cord-014516-r59usk02 903 4 twice twice RB cord-014516-r59usk02 903 5 daily daily RB cord-014516-r59usk02 903 6 ( ( -LRB- cord-014516-r59usk02 903 7 exenatide exenatide NN cord-014516-r59usk02 903 8 ) ) -RRB- cord-014516-r59usk02 903 9 as as RB cord-014516-r59usk02 903 10 well well RB cord-014516-r59usk02 903 11 as as IN cord-014516-r59usk02 903 12 once once RB cord-014516-r59usk02 903 13 weekly weekly JJ cord-014516-r59usk02 903 14 ( ( -LRB- cord-014516-r59usk02 903 15 exenatide exenatide IN cord-014516-r59usk02 903 16 extended extend VBN cord-014516-r59usk02 903 17 - - HYPH cord-014516-r59usk02 903 18 release release NN cord-014516-r59usk02 903 19 ( ( -LRB- cord-014516-r59usk02 903 20 ER ER NNP cord-014516-r59usk02 903 21 ) ) -RRB- cord-014516-r59usk02 903 22 ) ) -RRB- cord-014516-r59usk02 903 23 application application NN cord-014516-r59usk02 903 24 of of IN cord-014516-r59usk02 903 25 GLP-1 GLP-1 NNP cord-014516-r59usk02 903 26 agonists agonist NNS cord-014516-r59usk02 903 27 induced induce VBD cord-014516-r59usk02 903 28 pronounced pronounce VBD cord-014516-r59usk02 903 29 insulin insulin NN cord-014516-r59usk02 903 30 secretion secretion NN cord-014516-r59usk02 903 31 . . . cord-014516-r59usk02 904 1 Benefits benefit NNS cord-014516-r59usk02 904 2 of of IN cord-014516-r59usk02 904 3 exenatide exenatide NN cord-014516-r59usk02 904 4 ER ER NNP cord-014516-r59usk02 904 5 are be VBP cord-014516-r59usk02 904 6 the the DT cord-014516-r59usk02 904 7 regimen regimen NN cord-014516-r59usk02 904 8 of of IN cord-014516-r59usk02 904 9 once once RB cord-014516-r59usk02 904 10 weekly weekly JJ cord-014516-r59usk02 904 11 injection injection NN cord-014516-r59usk02 904 12 and and CC cord-014516-r59usk02 904 13 less less JJR cord-014516-r59usk02 904 14 side side NN cord-014516-r59usk02 904 15 effects effect NNS cord-014516-r59usk02 904 16 . . . cord-014516-r59usk02 905 1 The the DT cord-014516-r59usk02 905 2 objective objective NN cord-014516-r59usk02 905 3 of of IN cord-014516-r59usk02 905 4 the the DT cord-014516-r59usk02 905 5 study study NN cord-014516-r59usk02 905 6 was be VBD cord-014516-r59usk02 905 7 to to TO cord-014516-r59usk02 905 8 assess assess VB cord-014516-r59usk02 905 9 whether whether IN cord-014516-r59usk02 905 10 administration administration NN cord-014516-r59usk02 905 11 of of IN cord-014516-r59usk02 905 12 exenatide exenatide NNP cord-014516-r59usk02 905 13 ER ER NNP cord-014516-r59usk02 905 14 in in IN cord-014516-r59usk02 905 15 addition addition NN cord-014516-r59usk02 905 16 to to IN cord-014516-r59usk02 905 17 standard standard JJ cord-014516-r59usk02 905 18 treatment treatment NN cord-014516-r59usk02 905 19 leads lead VBZ cord-014516-r59usk02 905 20 to to IN cord-014516-r59usk02 905 21 improved improve VBN cord-014516-r59usk02 905 22 glycemic glycemic JJ cord-014516-r59usk02 905 23 control control NN cord-014516-r59usk02 905 24 and and CC cord-014516-r59usk02 905 25 higher high JJR cord-014516-r59usk02 905 26 remission remission NN cord-014516-r59usk02 905 27 rates rate NNS cord-014516-r59usk02 905 28 in in IN cord-014516-r59usk02 905 29 cats cat NNS cord-014516-r59usk02 905 30 with with IN cord-014516-r59usk02 905 31 newly newly RB cord-014516-r59usk02 905 32 diagnosed diagnose VBN cord-014516-r59usk02 905 33 diabetes diabetes NN cord-014516-r59usk02 905 34 . . . cord-014516-r59usk02 906 1 The the DT cord-014516-r59usk02 906 2 study study NN cord-014516-r59usk02 906 3 was be VBD cord-014516-r59usk02 906 4 designed design VBN cord-014516-r59usk02 906 5 as as IN cord-014516-r59usk02 906 6 a a DT cord-014516-r59usk02 906 7 prospective prospective JJ cord-014516-r59usk02 906 8 , , , cord-014516-r59usk02 906 9 placebo placebo NN cord-014516-r59usk02 906 10 - - HYPH cord-014516-r59usk02 906 11 controlled control VBN cord-014516-r59usk02 906 12 clinical clinical JJ cord-014516-r59usk02 906 13 trial trial NN cord-014516-r59usk02 906 14 . . . cord-014516-r59usk02 907 1 Cats cat NNS cord-014516-r59usk02 907 2 were be VBD cord-014516-r59usk02 907 3 randomly randomly RB cord-014516-r59usk02 907 4 assigned assign VBN cord-014516-r59usk02 907 5 to to IN cord-014516-r59usk02 907 6 two two CD cord-014516-r59usk02 907 7 groups group NNS cord-014516-r59usk02 907 8 receiving receive VBG cord-014516-r59usk02 907 9 exenatide exenatide NN cord-014516-r59usk02 907 10 ER ER NNP cord-014516-r59usk02 907 11 ( ( -LRB- cord-014516-r59usk02 907 12 group group NN cord-014516-r59usk02 907 13 1 1 CD cord-014516-r59usk02 907 14 : : : cord-014516-r59usk02 908 1 Bydureon Bydureon NNP cord-014516-r59usk02 908 2 â â NNP cord-014516-r59usk02 908 3 , , , cord-014516-r59usk02 908 4 200 200 CD cord-014516-r59usk02 908 5 mg mg NNP cord-014516-r59usk02 908 6 / / SYM cord-014516-r59usk02 908 7 kg kg NNP cord-014516-r59usk02 908 8 , , , cord-014516-r59usk02 908 9 q7d q7d NNP cord-014516-r59usk02 908 10 , , , cord-014516-r59usk02 908 11 SC SC NNP cord-014516-r59usk02 908 12 ) ) -RRB- cord-014516-r59usk02 908 13 or or CC cord-014516-r59usk02 908 14 0.9 0.9 CD cord-014516-r59usk02 908 15 % % NN cord-014516-r59usk02 908 16 saline saline NN cord-014516-r59usk02 908 17 solution solution NN cord-014516-r59usk02 908 18 ( ( -LRB- cord-014516-r59usk02 908 19 group group NN cord-014516-r59usk02 908 20 2 2 CD cord-014516-r59usk02 908 21 : : : cord-014516-r59usk02 908 22 q7d q7d ADD cord-014516-r59usk02 908 23 , , , cord-014516-r59usk02 908 24 SC SC NNP cord-014516-r59usk02 908 25 ) ) -RRB- cord-014516-r59usk02 908 26 . . . cord-014516-r59usk02 909 1 Both both DT cord-014516-r59usk02 909 2 groups group NNS cord-014516-r59usk02 909 3 additionally additionally RB cord-014516-r59usk02 909 4 received receive VBD cord-014516-r59usk02 909 5 insulin insulin NN cord-014516-r59usk02 909 6 glargine glargine NN cord-014516-r59usk02 909 7 ( ( -LRB- cord-014516-r59usk02 909 8 Lantus Lantus NNP cord-014516-r59usk02 909 9 â â NNP cord-014516-r59usk02 909 10 , , , cord-014516-r59usk02 909 11 initial initial JJ cord-014516-r59usk02 909 12 dose dose NN cord-014516-r59usk02 909 13 : : : cord-014516-r59usk02 909 14 ≤ ≤ NN cord-014516-r59usk02 909 15 4 4 CD cord-014516-r59usk02 909 16 kg kg NN cord-014516-r59usk02 909 17 : : : cord-014516-r59usk02 909 18 1.0 1.0 CD cord-014516-r59usk02 909 19 IU IU NNP cord-014516-r59usk02 909 20 , , , cord-014516-r59usk02 909 21 q12 q12 NN cord-014516-r59usk02 909 22 h h NN cord-014516-r59usk02 909 23 ; ; : cord-014516-r59usk02 909 24 > > NFP cord-014516-r59usk02 909 25 4 4 CD cord-014516-r59usk02 909 26 kg kg NNP cord-014516-r59usk02 909 27 1.5 1.5 CD cord-014516-r59usk02 909 28 - - SYM cord-014516-r59usk02 909 29 2.0 2.0 CD cord-014516-r59usk02 909 30 IU IU NNP cord-014516-r59usk02 909 31 , , , cord-014516-r59usk02 909 32 q12 q12 NN cord-014516-r59usk02 909 33 h h NNP cord-014516-r59usk02 909 34 ) ) -RRB- cord-014516-r59usk02 909 35 and and CC cord-014516-r59usk02 909 36 diet diet NNP cord-014516-r59usk02 909 37 ( ( -LRB- cord-014516-r59usk02 909 38 Purina Purina NNP cord-014516-r59usk02 909 39 DM DM NNP cord-014516-r59usk02 909 40 â â CD cord-014516-r59usk02 909 41 ) ) -RRB- cord-014516-r59usk02 909 42 . . . cord-014516-r59usk02 910 1 Exenatide Exenatide NNP cord-014516-r59usk02 910 2 ER ER NNP cord-014516-r59usk02 910 3 was be VBD cord-014516-r59usk02 910 4 applied apply VBN cord-014516-r59usk02 910 5 over over IN cord-014516-r59usk02 910 6 16 16 CD cord-014516-r59usk02 910 7 weeks week NNS cord-014516-r59usk02 910 8 or or CC cord-014516-r59usk02 910 9 , , , cord-014516-r59usk02 910 10 in in IN cord-014516-r59usk02 910 11 case case NN cord-014516-r59usk02 910 12 of of IN cord-014516-r59usk02 910 13 remission remission NN cord-014516-r59usk02 910 14 , , , cord-014516-r59usk02 910 15 for for IN cord-014516-r59usk02 910 16 4 4 CD cord-014516-r59usk02 910 17 additional additional JJ cord-014516-r59usk02 910 18 weeks week NNS cord-014516-r59usk02 910 19 after after IN cord-014516-r59usk02 910 20 cessation cessation NN cord-014516-r59usk02 910 21 of of IN cord-014516-r59usk02 910 22 insulin insulin NN cord-014516-r59usk02 910 23 application application NN cord-014516-r59usk02 910 24 . . . cord-014516-r59usk02 911 1 Cats cat NNS cord-014516-r59usk02 911 2 were be VBD cord-014516-r59usk02 911 3 rechecked rechecke VBN cord-014516-r59usk02 911 4 1 1 CD cord-014516-r59usk02 911 5 , , , cord-014516-r59usk02 911 6 3 3 CD cord-014516-r59usk02 911 7 , , , cord-014516-r59usk02 911 8 6 6 CD cord-014516-r59usk02 911 9 , , , cord-014516-r59usk02 911 10 10 10 CD cord-014516-r59usk02 911 11 and and CC cord-014516-r59usk02 911 12 16 16 CD cord-014516-r59usk02 911 13 weeks week NNS cord-014516-r59usk02 911 14 after after IN cord-014516-r59usk02 911 15 starting start VBG cord-014516-r59usk02 911 16 therapy therapy NN cord-014516-r59usk02 911 17 . . . cord-014516-r59usk02 912 1 Remission remission NN cord-014516-r59usk02 912 2 of of IN cord-014516-r59usk02 912 3 diabetes diabetes NN cord-014516-r59usk02 912 4 was be VBD cord-014516-r59usk02 912 5 defined define VBN cord-014516-r59usk02 912 6 as as IN cord-014516-r59usk02 912 7 absence absence NN cord-014516-r59usk02 912 8 of of IN cord-014516-r59usk02 912 9 clinical clinical JJ cord-014516-r59usk02 912 10 signs sign NNS cord-014516-r59usk02 912 11 of of IN cord-014516-r59usk02 912 12 diabetes diabetes NN cord-014516-r59usk02 912 13 and and CC cord-014516-r59usk02 912 14 normal normal JJ cord-014516-r59usk02 912 15 blood blood NN cord-014516-r59usk02 912 16 glucose glucose NN cord-014516-r59usk02 912 17 and and CC cord-014516-r59usk02 912 18 fructosamine fructosamine NN cord-014516-r59usk02 912 19 concentrations concentration NNS cord-014516-r59usk02 912 20 for for IN cord-014516-r59usk02 912 21 at at RB cord-014516-r59usk02 912 22 least least JJS cord-014516-r59usk02 912 23 4 4 CD cord-014516-r59usk02 912 24 weeks week NNS cord-014516-r59usk02 912 25 after after IN cord-014516-r59usk02 912 26 discontinuing discontinue VBG cord-014516-r59usk02 912 27 insulin insulin NN cord-014516-r59usk02 912 28 injections injection NNS cord-014516-r59usk02 912 29 . . . cord-014516-r59usk02 913 1 So so IN cord-014516-r59usk02 913 2 far far RB cord-014516-r59usk02 913 3 17 17 CD cord-014516-r59usk02 913 4 cats cat NNS cord-014516-r59usk02 913 5 have have VBP cord-014516-r59usk02 913 6 completed complete VBN cord-014516-r59usk02 913 7 the the DT cord-014516-r59usk02 913 8 study study NN cord-014516-r59usk02 913 9 . . . cord-014516-r59usk02 914 1 Mild mild JJ cord-014516-r59usk02 914 2 and and CC cord-014516-r59usk02 914 3 transient transient JJ cord-014516-r59usk02 914 4 side side NN cord-014516-r59usk02 914 5 effects effect NNS cord-014516-r59usk02 914 6 in in IN cord-014516-r59usk02 914 7 group group NN cord-014516-r59usk02 914 8 1 1 CD cord-014516-r59usk02 914 9 ( ( -LRB- cord-014516-r59usk02 914 10 n n NN cord-014516-r59usk02 914 11 = = SYM cord-014516-r59usk02 914 12 9 9 CD cord-014516-r59usk02 914 13 ) ) -RRB- cord-014516-r59usk02 914 14 were be VBD cord-014516-r59usk02 914 15 reduced reduce VBN cord-014516-r59usk02 914 16 appetite appetite NN cord-014516-r59usk02 914 17 ( ( -LRB- cord-014516-r59usk02 914 18 n n NN cord-014516-r59usk02 914 19 = = SYM cord-014516-r59usk02 914 20 6 6 CD cord-014516-r59usk02 914 21 ) ) -RRB- cord-014516-r59usk02 914 22 , , , cord-014516-r59usk02 914 23 nausea nausea NN cord-014516-r59usk02 914 24 ( ( -LRB- cord-014516-r59usk02 914 25 n n NN cord-014516-r59usk02 914 26 = = SYM cord-014516-r59usk02 914 27 2 2 CD cord-014516-r59usk02 914 28 ) ) -RRB- cord-014516-r59usk02 914 29 , , , cord-014516-r59usk02 914 30 vomitus vomitus NN cord-014516-r59usk02 914 31 ( ( -LRB- cord-014516-r59usk02 914 32 n n NN cord-014516-r59usk02 914 33 = = SYM cord-014516-r59usk02 914 34 4 4 CD cord-014516-r59usk02 914 35 ) ) -RRB- cord-014516-r59usk02 914 36 , , , cord-014516-r59usk02 914 37 tiredness tiredness NN cord-014516-r59usk02 914 38 ( ( -LRB- cord-014516-r59usk02 914 39 n n NN cord-014516-r59usk02 914 40 = = SYM cord-014516-r59usk02 914 41 2 2 CD cord-014516-r59usk02 914 42 ) ) -RRB- cord-014516-r59usk02 914 43 and and CC cord-014516-r59usk02 914 44 hiding hide VBG cord-014516-r59usk02 914 45 in in IN cord-014516-r59usk02 914 46 dark dark JJ cord-014516-r59usk02 914 47 spots spot NNS cord-014516-r59usk02 914 48 of of IN cord-014516-r59usk02 914 49 the the DT cord-014516-r59usk02 914 50 house house NN cord-014516-r59usk02 914 51 ( ( -LRB- cord-014516-r59usk02 914 52 n n NN cord-014516-r59usk02 914 53 = = SYM cord-014516-r59usk02 914 54 2 2 CD cord-014516-r59usk02 914 55 ) ) -RRB- cord-014516-r59usk02 914 56 . . . cord-014516-r59usk02 915 1 In in IN cord-014516-r59usk02 915 2 group group NN cord-014516-r59usk02 915 3 1 1 CD cord-014516-r59usk02 915 4 remission remission NN cord-014516-r59usk02 915 5 was be VBD cord-014516-r59usk02 915 6 achieved achieve VBN cord-014516-r59usk02 915 7 in in IN cord-014516-r59usk02 915 8 4/9 4/9 CD cord-014516-r59usk02 915 9 ( ( -LRB- cord-014516-r59usk02 915 10 44 44 CD cord-014516-r59usk02 915 11 % % NN cord-014516-r59usk02 915 12 ) ) -RRB- cord-014516-r59usk02 915 13 cats cat NNS cord-014516-r59usk02 915 14 and and CC cord-014516-r59usk02 915 15 good good JJ cord-014516-r59usk02 915 16 metabolic metabolic JJ cord-014516-r59usk02 915 17 control control NN cord-014516-r59usk02 915 18 in in IN cord-014516-r59usk02 915 19 4/5 4/5 CD cord-014516-r59usk02 915 20 ( ( -LRB- cord-014516-r59usk02 915 21 80 80 CD cord-014516-r59usk02 915 22 % % NN cord-014516-r59usk02 915 23 ) ) -RRB- cord-014516-r59usk02 915 24 nonremission nonremission NN cord-014516-r59usk02 915 25 cats cat NNS cord-014516-r59usk02 915 26 . . . cord-014516-r59usk02 916 1 In in IN cord-014516-r59usk02 916 2 group group NN cord-014516-r59usk02 916 3 2 2 CD cord-014516-r59usk02 916 4 remission remission NN cord-014516-r59usk02 916 5 was be VBD cord-014516-r59usk02 916 6 achieved achieve VBN cord-014516-r59usk02 916 7 in in IN cord-014516-r59usk02 916 8 2/8 2/8 CD cord-014516-r59usk02 916 9 ( ( -LRB- cord-014516-r59usk02 916 10 25 25 CD cord-014516-r59usk02 916 11 % % NN cord-014516-r59usk02 916 12 ) ) -RRB- cord-014516-r59usk02 916 13 cats cat NNS cord-014516-r59usk02 916 14 and and CC cord-014516-r59usk02 916 15 good good JJ cord-014516-r59usk02 916 16 metabolic metabolic JJ cord-014516-r59usk02 916 17 control control NN cord-014516-r59usk02 916 18 in in IN cord-014516-r59usk02 916 19 4/6 4/6 CD cord-014516-r59usk02 916 20 ( ( -LRB- cord-014516-r59usk02 916 21 66 66 CD cord-014516-r59usk02 916 22 % % NN cord-014516-r59usk02 916 23 ) ) -RRB- cord-014516-r59usk02 916 24 non non JJ cord-014516-r59usk02 916 25 - - JJ cord-014516-r59usk02 916 26 remission remission JJ cord-014516-r59usk02 916 27 cats cat NNS cord-014516-r59usk02 916 28 . . . cord-014516-r59usk02 917 1 Median median JJ cord-014516-r59usk02 917 2 insulin insulin NN cord-014516-r59usk02 917 3 dose dose NN cord-014516-r59usk02 917 4 given give VBN cord-014516-r59usk02 917 5 during during IN cord-014516-r59usk02 917 6 the the DT cord-014516-r59usk02 917 7 study study NN cord-014516-r59usk02 917 8 period period NN cord-014516-r59usk02 917 9 was be VBD cord-014516-r59usk02 917 10 0.47 0.47 CD cord-014516-r59usk02 917 11 IU/ iu/ DT cord-014516-r59usk02 917 12 kg kg NN cord-014516-r59usk02 917 13 / / SYM cord-014516-r59usk02 917 14 day day NN cord-014516-r59usk02 917 15 in in IN cord-014516-r59usk02 917 16 group group NN cord-014516-r59usk02 917 17 1 1 CD cord-014516-r59usk02 917 18 and and CC cord-014516-r59usk02 917 19 0.56 0.56 CD cord-014516-r59usk02 917 20 IU IU NNP cord-014516-r59usk02 917 21 / / SYM cord-014516-r59usk02 917 22 kg kg NNP cord-014516-r59usk02 918 1 /day /day NFP cord-014516-r59usk02 918 2 in in IN cord-014516-r59usk02 918 3 group group NN cord-014516-r59usk02 918 4 2 2 CD cord-014516-r59usk02 918 5 . . . cord-014516-r59usk02 919 1 The the DT cord-014516-r59usk02 919 2 preliminary preliminary JJ cord-014516-r59usk02 919 3 results result NNS cord-014516-r59usk02 919 4 suggest suggest VBP cord-014516-r59usk02 919 5 that that IN cord-014516-r59usk02 919 6 exenatide exenatide NN cord-014516-r59usk02 919 7 ER ER NNP cord-014516-r59usk02 919 8 can can MD cord-014516-r59usk02 919 9 be be VB cord-014516-r59usk02 919 10 used use VBN cord-014516-r59usk02 919 11 safely safely RB cord-014516-r59usk02 919 12 in in IN cord-014516-r59usk02 919 13 diabetic diabetic JJ cord-014516-r59usk02 919 14 cats cat NNS cord-014516-r59usk02 919 15 . . . cord-014516-r59usk02 920 1 A a DT cord-014516-r59usk02 920 2 tendency tendency NN cord-014516-r59usk02 920 3 for for IN cord-014516-r59usk02 920 4 higher high JJR cord-014516-r59usk02 920 5 remission remission NN cord-014516-r59usk02 920 6 rate rate NN cord-014516-r59usk02 920 7 , , , cord-014516-r59usk02 920 8 better well JJR cord-014516-r59usk02 920 9 metabolic metabolic JJ cord-014516-r59usk02 920 10 control control NN cord-014516-r59usk02 920 11 and and CC cord-014516-r59usk02 920 12 lower low JJR cord-014516-r59usk02 920 13 insulin insulin NN cord-014516-r59usk02 920 14 requirement requirement NN cord-014516-r59usk02 920 15 was be VBD cord-014516-r59usk02 920 16 seen see VBN cord-014516-r59usk02 920 17 when when WRB cord-014516-r59usk02 920 18 exenatide exenatide NN cord-014516-r59usk02 920 19 ER ER NNP cord-014516-r59usk02 920 20 was be VBD cord-014516-r59usk02 920 21 added add VBN cord-014516-r59usk02 920 22 to to IN cord-014516-r59usk02 920 23 the the DT cord-014516-r59usk02 920 24 standard standard JJ cord-014516-r59usk02 920 25 treatment treatment NN cord-014516-r59usk02 920 26 regimen regimen NN cord-014516-r59usk02 920 27 . . . cord-014516-r59usk02 921 1 Further further JJ cord-014516-r59usk02 921 2 cases case NNS cord-014516-r59usk02 921 3 need need VBP cord-014516-r59usk02 921 4 to to TO cord-014516-r59usk02 921 5 be be VB cord-014516-r59usk02 921 6 evaluated evaluate VBN cord-014516-r59usk02 921 7 to to TO cord-014516-r59usk02 921 8 verify verify VB cord-014516-r59usk02 921 9 the the DT cord-014516-r59usk02 921 10 potential potential JJ cord-014516-r59usk02 921 11 beneficial beneficial JJ cord-014516-r59usk02 921 12 role role NN cord-014516-r59usk02 921 13 of of IN cord-014516-r59usk02 921 14 exenatide exenatide NN cord-014516-r59usk02 921 15 ER ER NNP cord-014516-r59usk02 921 16 . . . cord-014516-r59usk02 922 1 No no DT cord-014516-r59usk02 922 2 conflicts conflict NNS cord-014516-r59usk02 922 3 of of IN cord-014516-r59usk02 922 4 interest interest NN cord-014516-r59usk02 922 5 reported report VBN cord-014516-r59usk02 922 6 . . . cord-014516-r59usk02 923 1 Feline feline JJ cord-014516-r59usk02 923 2 diabetes diabetes NN cord-014516-r59usk02 923 3 mellitus mellitus NN cord-014516-r59usk02 923 4 shares share VBZ cord-014516-r59usk02 923 5 many many JJ cord-014516-r59usk02 923 6 similarities similarity NNS cord-014516-r59usk02 923 7 with with IN cord-014516-r59usk02 923 8 human human JJ cord-014516-r59usk02 923 9 type type NN cord-014516-r59usk02 923 10 2 2 CD cord-014516-r59usk02 923 11 diabetes diabetes NN cord-014516-r59usk02 923 12 mellitus mellitus NN cord-014516-r59usk02 923 13 ( ( -LRB- cord-014516-r59usk02 923 14 T2DM T2DM NNP cord-014516-r59usk02 923 15 ) ) -RRB- cord-014516-r59usk02 923 16 , , , cord-014516-r59usk02 923 17 including include VBG cord-014516-r59usk02 923 18 clinical clinical JJ cord-014516-r59usk02 923 19 , , , cord-014516-r59usk02 923 20 physiological physiological JJ cord-014516-r59usk02 923 21 and and CC cord-014516-r59usk02 923 22 pathological pathological JJ cord-014516-r59usk02 923 23 features feature NNS cord-014516-r59usk02 923 24 of of IN cord-014516-r59usk02 923 25 the the DT cord-014516-r59usk02 923 26 disease disease NN cord-014516-r59usk02 923 27 . . . cord-014516-r59usk02 924 1 Domestic domestic JJ cord-014516-r59usk02 924 2 cats cat NNS cord-014516-r59usk02 924 3 spontaneously spontaneously RB cord-014516-r59usk02 924 4 develop develop VBP cord-014516-r59usk02 924 5 diabetes diabetes NN cord-014516-r59usk02 924 6 associated associate VBN cord-014516-r59usk02 924 7 with with IN cord-014516-r59usk02 924 8 insulin insulin NN cord-014516-r59usk02 924 9 resistance resistance NN cord-014516-r59usk02 924 10 in in IN cord-014516-r59usk02 924 11 their -PRON- PRP$ cord-014516-r59usk02 924 12 middle middle JJ cord-014516-r59usk02 924 13 age age NN cord-014516-r59usk02 924 14 or or CC cord-014516-r59usk02 924 15 later later RB cord-014516-r59usk02 924 16 , , , cord-014516-r59usk02 924 17 with with IN cord-014516-r59usk02 924 18 residual residual JJ cord-014516-r59usk02 924 19 but but CC cord-014516-r59usk02 924 20 declining decline VBG cord-014516-r59usk02 924 21 insulin insulin NN cord-014516-r59usk02 924 22 secretion secretion NN cord-014516-r59usk02 924 23 . . . cord-014516-r59usk02 925 1 Humans human NNS cord-014516-r59usk02 925 2 and and CC cord-014516-r59usk02 925 3 cats cat NNS cord-014516-r59usk02 925 4 share share VBP cord-014516-r59usk02 925 5 the the DT cord-014516-r59usk02 925 6 same same JJ cord-014516-r59usk02 925 7 environment environment NN cord-014516-r59usk02 925 8 and and CC cord-014516-r59usk02 925 9 risk risk NN cord-014516-r59usk02 925 10 factors factor NNS cord-014516-r59usk02 925 11 for for IN cord-014516-r59usk02 925 12 diabetes diabetes NN cord-014516-r59usk02 925 13 , , , cord-014516-r59usk02 925 14 such such JJ cord-014516-r59usk02 925 15 as as IN cord-014516-r59usk02 925 16 obesity obesity NN cord-014516-r59usk02 925 17 and and CC cord-014516-r59usk02 925 18 physical physical JJ cord-014516-r59usk02 925 19 inactivity inactivity NN cord-014516-r59usk02 925 20 . . . cord-014516-r59usk02 926 1 Moreover moreover RB cord-014516-r59usk02 926 2 , , , cord-014516-r59usk02 926 3 amyloid amyloid NN cord-014516-r59usk02 926 4 formation formation NN cord-014516-r59usk02 926 5 and and CC cord-014516-r59usk02 926 6 loss loss NN cord-014516-r59usk02 926 7 of of IN cord-014516-r59usk02 926 8 beta beta NN cord-014516-r59usk02 926 9 cells cell NNS cord-014516-r59usk02 926 10 are be VBP cord-014516-r59usk02 926 11 found find VBN cord-014516-r59usk02 926 12 in in IN cord-014516-r59usk02 926 13 the the DT cord-014516-r59usk02 926 14 diabetic diabetic JJ cord-014516-r59usk02 926 15 cat cat NN cord-014516-r59usk02 926 16 pancreas pancrea NNS cord-014516-r59usk02 926 17 , , , cord-014516-r59usk02 926 18 as as IN cord-014516-r59usk02 926 19 in in IN cord-014516-r59usk02 926 20 humans human NNS cord-014516-r59usk02 926 21 . . . cord-014516-r59usk02 927 1 Subsequently subsequently RB cord-014516-r59usk02 927 2 , , , cord-014516-r59usk02 927 3 studying study VBG cord-014516-r59usk02 927 4 the the DT cord-014516-r59usk02 927 5 molecular molecular JJ cord-014516-r59usk02 927 6 mechanisms mechanism NNS cord-014516-r59usk02 927 7 in in IN cord-014516-r59usk02 927 8 the the DT cord-014516-r59usk02 927 9 failing fail VBG cord-014516-r59usk02 927 10 beta beta NN cord-014516-r59usk02 927 11 cells cell NNS cord-014516-r59usk02 927 12 may may MD cord-014516-r59usk02 927 13 contribute contribute VB cord-014516-r59usk02 927 14 to to IN cord-014516-r59usk02 927 15 a a DT cord-014516-r59usk02 927 16 better well JJR cord-014516-r59usk02 927 17 understanding understanding NN cord-014516-r59usk02 927 18 of of IN cord-014516-r59usk02 927 19 the the DT cord-014516-r59usk02 927 20 pathophysiology pathophysiology NN cord-014516-r59usk02 927 21 of of IN cord-014516-r59usk02 927 22 T2DM T2DM NNP cord-014516-r59usk02 927 23 in in IN cord-014516-r59usk02 927 24 both both DT cord-014516-r59usk02 927 25 cats cat NNS cord-014516-r59usk02 927 26 and and CC cord-014516-r59usk02 927 27 humans human NNS cord-014516-r59usk02 927 28 . . . cord-014516-r59usk02 928 1 The the DT cord-014516-r59usk02 928 2 aim aim NN cord-014516-r59usk02 928 3 of of IN cord-014516-r59usk02 928 4 the the DT cord-014516-r59usk02 928 5 present present JJ cord-014516-r59usk02 928 6 study study NN cord-014516-r59usk02 928 7 was be VBD cord-014516-r59usk02 928 8 to to TO cord-014516-r59usk02 928 9 develop develop VB cord-014516-r59usk02 928 10 a a DT cord-014516-r59usk02 928 11 method method NN cord-014516-r59usk02 928 12 to to TO cord-014516-r59usk02 928 13 study study VB cord-014516-r59usk02 928 14 mRNA mrna NN cord-014516-r59usk02 928 15 expression expression NN cord-014516-r59usk02 928 16 of of IN cord-014516-r59usk02 928 17 islet islet NN cord-014516-r59usk02 928 18 - - HYPH cord-014516-r59usk02 928 19 specific specific JJ cord-014516-r59usk02 928 20 genes gene NNS cord-014516-r59usk02 928 21 in in IN cord-014516-r59usk02 928 22 healthy healthy JJ cord-014516-r59usk02 928 23 and and CC cord-014516-r59usk02 928 24 diabetic diabetic JJ cord-014516-r59usk02 928 25 cats cat NNS cord-014516-r59usk02 928 26 . . . cord-014516-r59usk02 929 1 Previous previous JJ cord-014516-r59usk02 929 2 attempts attempt NNS cord-014516-r59usk02 929 3 in in IN cord-014516-r59usk02 929 4 isolating isolate VBG cord-014516-r59usk02 929 5 feline feline JJ cord-014516-r59usk02 929 6 islets islet NNS cord-014516-r59usk02 929 7 with with IN cord-014516-r59usk02 929 8 different different JJ cord-014516-r59usk02 929 9 collagenase collagenase NN cord-014516-r59usk02 929 10 - - HYPH cord-014516-r59usk02 929 11 based base VBN cord-014516-r59usk02 929 12 protocols protocol NNS cord-014516-r59usk02 929 13 have have VBP cord-014516-r59usk02 929 14 led lead VBN cord-014516-r59usk02 929 15 to to IN cord-014516-r59usk02 929 16 damaged damage VBN cord-014516-r59usk02 929 17 islets islet NNS cord-014516-r59usk02 929 18 or or CC cord-014516-r59usk02 929 19 islets islet NNS cord-014516-r59usk02 929 20 coated coat VBN cord-014516-r59usk02 929 21 with with IN cord-014516-r59usk02 929 22 exocrine exocrine JJ cord-014516-r59usk02 929 23 acinar acinar NN cord-014516-r59usk02 929 24 cells cell NNS cord-014516-r59usk02 929 25 , , , cord-014516-r59usk02 929 26 which which WDT cord-014516-r59usk02 929 27 either either DT cord-014516-r59usk02 929 28 way way NN cord-014516-r59usk02 929 29 compromise compromise VBP cord-014516-r59usk02 929 30 the the DT cord-014516-r59usk02 929 31 results result NNS cord-014516-r59usk02 929 32 obtained obtain VBN cord-014516-r59usk02 929 33 from from IN cord-014516-r59usk02 929 34 gene gene NN cord-014516-r59usk02 929 35 expression expression NN cord-014516-r59usk02 929 36 studies study NNS cord-014516-r59usk02 929 37 . . . cord-014516-r59usk02 930 1 By by IN cord-014516-r59usk02 930 2 using use VBG cord-014516-r59usk02 930 3 the the DT cord-014516-r59usk02 930 4 laser laser NN cord-014516-r59usk02 930 5 microdissection microdissection NN cord-014516-r59usk02 930 6 technique technique NN cord-014516-r59usk02 930 7 , , , cord-014516-r59usk02 930 8 we -PRON- PRP cord-014516-r59usk02 930 9 were be VBD cord-014516-r59usk02 930 10 able able JJ cord-014516-r59usk02 930 11 to to TO cord-014516-r59usk02 930 12 sample sample VB cord-014516-r59usk02 930 13 islets islet NNS cord-014516-r59usk02 930 14 that that WDT cord-014516-r59usk02 930 15 were be VBD cord-014516-r59usk02 930 16 not not RB cord-014516-r59usk02 930 17 contaminated contaminate VBN cord-014516-r59usk02 930 18 with with IN cord-014516-r59usk02 930 19 exocrine exocrine JJ cord-014516-r59usk02 930 20 tissue tissue NN cord-014516-r59usk02 930 21 , , , cord-014516-r59usk02 930 22 from from IN cord-014516-r59usk02 930 23 both both CC cord-014516-r59usk02 930 24 healthy healthy JJ cord-014516-r59usk02 930 25 and and CC cord-014516-r59usk02 930 26 diabetic diabetic JJ cord-014516-r59usk02 930 27 cats cat NNS cord-014516-r59usk02 930 28 . . . cord-014516-r59usk02 931 1 High High NNP cord-014516-r59usk02 931 2 RNA RNA NNP cord-014516-r59usk02 931 3 quality quality NN cord-014516-r59usk02 931 4 was be VBD cord-014516-r59usk02 931 5 confirmed confirm VBN cord-014516-r59usk02 931 6 with with IN cord-014516-r59usk02 931 7 gel gel NN cord-014516-r59usk02 931 8 electrophoresis electrophoresis NN cord-014516-r59usk02 931 9 . . . cord-014516-r59usk02 932 1 By by IN cord-014516-r59usk02 932 2 quantitative quantitative JJ cord-014516-r59usk02 932 3 real real JJ cord-014516-r59usk02 932 4 - - HYPH cord-014516-r59usk02 932 5 time time NN cord-014516-r59usk02 932 6 PCR PCR NNP cord-014516-r59usk02 932 7 ( ( -LRB- cord-014516-r59usk02 932 8 qRT qRT NNP cord-014516-r59usk02 932 9 - - HYPH cord-014516-r59usk02 932 10 PCR PCR NNP cord-014516-r59usk02 932 11 ) ) -RRB- cord-014516-r59usk02 932 12 , , , cord-014516-r59usk02 932 13 mRNA mrna NN cord-014516-r59usk02 932 14 levels level NNS cord-014516-r59usk02 932 15 of of IN cord-014516-r59usk02 932 16 the the DT cord-014516-r59usk02 932 17 islet islet NN cord-014516-r59usk02 932 18 - - HYPH cord-014516-r59usk02 932 19 specific specific JJ cord-014516-r59usk02 932 20 genes gene NNS cord-014516-r59usk02 932 21 insulin insulin NN cord-014516-r59usk02 932 22 , , , cord-014516-r59usk02 932 23 PDX-1 PDX-1 NNP cord-014516-r59usk02 932 24 , , , cord-014516-r59usk02 932 25 IAPP IAPP NNP cord-014516-r59usk02 932 26 , , , cord-014516-r59usk02 932 27 CHGA CHGA NNP cord-014516-r59usk02 932 28 and and CC cord-014516-r59usk02 932 29 IA-2 IA-2 NNP cord-014516-r59usk02 932 30 were be VBD cord-014516-r59usk02 932 31 detected detect VBN cord-014516-r59usk02 932 32 in in IN cord-014516-r59usk02 932 33 both both CC cord-014516-r59usk02 932 34 healthy healthy JJ cord-014516-r59usk02 932 35 and and CC cord-014516-r59usk02 932 36 diabetic diabetic JJ cord-014516-r59usk02 932 37 cats cat NNS cord-014516-r59usk02 932 38 . . . cord-014516-r59usk02 933 1 We -PRON- PRP cord-014516-r59usk02 933 2 used use VBD cord-014516-r59usk02 933 3 actin actin NN cord-014516-r59usk02 933 4 b b NN cord-014516-r59usk02 933 5 , , , cord-014516-r59usk02 933 6 GAPDH GAPDH NNP cord-014516-r59usk02 933 7 and and CC cord-014516-r59usk02 933 8 RPS7 RPS7 NNP cord-014516-r59usk02 933 9 as as IN cord-014516-r59usk02 933 10 internal internal JJ cord-014516-r59usk02 933 11 reference reference NN cord-014516-r59usk02 933 12 genes gene NNS cord-014516-r59usk02 933 13 for for IN cord-014516-r59usk02 933 14 normalizations normalization NNS cord-014516-r59usk02 933 15 of of IN cord-014516-r59usk02 933 16 our -PRON- PRP$ cord-014516-r59usk02 933 17 qRT qRT NNP cord-014516-r59usk02 933 18 - - HYPH cord-014516-r59usk02 933 19 PCR PCR NNP cord-014516-r59usk02 933 20 data datum NNS cord-014516-r59usk02 933 21 . . . cord-014516-r59usk02 934 1 The the DT cord-014516-r59usk02 934 2 laser laser NN cord-014516-r59usk02 934 3 microdissection microdissection NN cord-014516-r59usk02 934 4 technique technique NN cord-014516-r59usk02 934 5 allows allow VBZ cord-014516-r59usk02 934 6 studies study NNS cord-014516-r59usk02 934 7 of of IN cord-014516-r59usk02 934 8 islets islet NNS cord-014516-r59usk02 934 9 without without IN cord-014516-r59usk02 934 10 contamination contamination NN cord-014516-r59usk02 934 11 of of IN cord-014516-r59usk02 934 12 acinar acinar JJ cord-014516-r59usk02 934 13 cells cell NNS cord-014516-r59usk02 934 14 , , , cord-014516-r59usk02 934 15 as as IN cord-014516-r59usk02 934 16 shown show VBN cord-014516-r59usk02 934 17 in in IN cord-014516-r59usk02 934 18 this this DT cord-014516-r59usk02 934 19 study study NN cord-014516-r59usk02 934 20 , , , cord-014516-r59usk02 934 21 and and CC cord-014516-r59usk02 934 22 is be VBZ cord-014516-r59usk02 934 23 of of IN cord-014516-r59usk02 934 24 great great JJ cord-014516-r59usk02 934 25 advantage advantage NN cord-014516-r59usk02 934 26 since since IN cord-014516-r59usk02 934 27 it -PRON- PRP cord-014516-r59usk02 934 28 is be VBZ cord-014516-r59usk02 934 29 difficult difficult JJ cord-014516-r59usk02 934 30 to to TO cord-014516-r59usk02 934 31 get get VB cord-014516-r59usk02 934 32 pure pure JJ cord-014516-r59usk02 934 33 feline feline JJ cord-014516-r59usk02 934 34 islets islet NNS cord-014516-r59usk02 934 35 from from IN cord-014516-r59usk02 934 36 collagenase collagenase NNP cord-014516-r59usk02 934 37 - - HYPH cord-014516-r59usk02 934 38 based base VBN cord-014516-r59usk02 934 39 isolation isolation NN cord-014516-r59usk02 934 40 . . . cord-014516-r59usk02 935 1 Differences difference NNS cord-014516-r59usk02 935 2 in in IN cord-014516-r59usk02 935 3 gene gene NN cord-014516-r59usk02 935 4 expression expression NN cord-014516-r59usk02 935 5 in in IN cord-014516-r59usk02 935 6 healthy healthy JJ cord-014516-r59usk02 935 7 and and CC cord-014516-r59usk02 935 8 diabetic diabetic JJ cord-014516-r59usk02 935 9 cats cat NNS cord-014516-r59usk02 935 10 may may MD cord-014516-r59usk02 935 11 reveal reveal VB cord-014516-r59usk02 935 12 underlying underlie VBG cord-014516-r59usk02 935 13 mechanisms mechanism NNS cord-014516-r59usk02 935 14 for for IN cord-014516-r59usk02 935 15 beta beta JJ cord-014516-r59usk02 935 16 cell cell NN cord-014516-r59usk02 935 17 dysfunction dysfunction NN cord-014516-r59usk02 935 18 and and CC cord-014516-r59usk02 935 19 decreased decrease VBD cord-014516-r59usk02 935 20 beta beta JJ cord-014516-r59usk02 935 21 cell cell NN cord-014516-r59usk02 935 22 mass mass NN cord-014516-r59usk02 935 23 in in IN cord-014516-r59usk02 935 24 human human JJ cord-014516-r59usk02 935 25 and and CC cord-014516-r59usk02 935 26 feline feline JJ cord-014516-r59usk02 935 27 type type NN cord-014516-r59usk02 935 28 2 2 CD cord-014516-r59usk02 935 29 diabetes diabete NNS cord-014516-r59usk02 935 30 . . . cord-014516-r59usk02 936 1 Conflicts conflict NNS cord-014516-r59usk02 936 2 of of IN cord-014516-r59usk02 936 3 interest interest NN cord-014516-r59usk02 936 4 : : : cord-014516-r59usk02 936 5 The the DT cord-014516-r59usk02 936 6 study study NN cord-014516-r59usk02 936 7 was be VBD cord-014516-r59usk02 936 8 financially financially RB cord-014516-r59usk02 936 9 supported support VBN cord-014516-r59usk02 936 10 by by IN cord-014516-r59usk02 936 11 the the DT cord-014516-r59usk02 936 12 Swedish Swedish NNP cord-014516-r59usk02 936 13 Juvenile Juvenile NNP cord-014516-r59usk02 936 14 Diabetes Diabetes NNP cord-014516-r59usk02 936 15 Foundation Foundation NNP cord-014516-r59usk02 936 16 , , , cord-014516-r59usk02 936 17 the the DT cord-014516-r59usk02 936 18 Fredrik Fredrik NNP cord-014516-r59usk02 936 19 and and CC cord-014516-r59usk02 936 20 Ingrid Ingrid NNP cord-014516-r59usk02 936 21 Thuring Thuring NNP cord-014516-r59usk02 936 22 Foundation Foundation NNP cord-014516-r59usk02 936 23 , , , cord-014516-r59usk02 936 24 the the DT cord-014516-r59usk02 936 25 Magnus Magnus NNP cord-014516-r59usk02 936 26 Bergvall Bergvall NNP cord-014516-r59usk02 936 27 Foundation Foundation NNP cord-014516-r59usk02 936 28 , , , cord-014516-r59usk02 936 29 the the DT cord-014516-r59usk02 936 30 Lars Lars NNP cord-014516-r59usk02 936 31 Hierta Hierta NNP cord-014516-r59usk02 936 32 Memorial Memorial NNP cord-014516-r59usk02 936 33 Foundation Foundation NNP cord-014516-r59usk02 936 34 , , , cord-014516-r59usk02 936 35 and and CC cord-014516-r59usk02 936 36 the the DT cord-014516-r59usk02 936 37 Foundation Foundation NNP cord-014516-r59usk02 936 38 for for IN cord-014516-r59usk02 936 39 Research Research NNP cord-014516-r59usk02 936 40 , , , cord-014516-r59usk02 936 41 Agria Agria NNP cord-014516-r59usk02 936 42 Insurance Insurance NNP cord-014516-r59usk02 936 43 Company Company NNP cord-014516-r59usk02 936 44 . . . cord-014516-r59usk02 937 1 Feline feline JJ cord-014516-r59usk02 937 2 acromegaly acromegaly NN cord-014516-r59usk02 937 3 is be VBZ cord-014516-r59usk02 937 4 an an DT cord-014516-r59usk02 937 5 increasingly increasingly RB cord-014516-r59usk02 937 6 recognised recognise VBN cord-014516-r59usk02 937 7 endocrinopathy endocrinopathy NN cord-014516-r59usk02 937 8 among among IN cord-014516-r59usk02 937 9 diabetic diabetic JJ cord-014516-r59usk02 937 10 cats cat NNS cord-014516-r59usk02 937 11 , , , cord-014516-r59usk02 937 12 caused cause VBN cord-014516-r59usk02 937 13 by by IN cord-014516-r59usk02 937 14 chronic chronic JJ cord-014516-r59usk02 937 15 excessive excessive JJ cord-014516-r59usk02 937 16 growth growth NN cord-014516-r59usk02 937 17 hormone hormone NN cord-014516-r59usk02 937 18 secretion secretion NN cord-014516-r59usk02 937 19 by by IN cord-014516-r59usk02 937 20 a a DT cord-014516-r59usk02 937 21 functional functional JJ cord-014516-r59usk02 937 22 somatotrophinoma somatotrophinoma NN cord-014516-r59usk02 937 23 in in IN cord-014516-r59usk02 937 24 the the DT cord-014516-r59usk02 937 25 pars pars NNP cord-014516-r59usk02 937 26 distalis distalis NNP cord-014516-r59usk02 937 27 of of IN cord-014516-r59usk02 937 28 the the DT cord-014516-r59usk02 937 29 anterior anterior JJ cord-014516-r59usk02 937 30 pituitary pituitary JJ cord-014516-r59usk02 937 31 gland gland NN cord-014516-r59usk02 937 32 . . . cord-014516-r59usk02 938 1 The the DT cord-014516-r59usk02 938 2 majority majority NN cord-014516-r59usk02 938 3 of of IN cord-014516-r59usk02 938 4 human human JJ cord-014516-r59usk02 938 5 somatotrophinomas somatotrophinoma NNS cord-014516-r59usk02 938 6 are be VBP cord-014516-r59usk02 938 7 sporadic sporadic JJ cord-014516-r59usk02 938 8 , , , cord-014516-r59usk02 938 9 however however RB cord-014516-r59usk02 938 10 up up IN cord-014516-r59usk02 938 11 to to TO cord-014516-r59usk02 938 12 20 20 CD cord-014516-r59usk02 938 13 % % NN cord-014516-r59usk02 938 14 of of IN cord-014516-r59usk02 938 15 familial familial JJ cord-014516-r59usk02 938 16 isolated isolate VBN cord-014516-r59usk02 938 17 pituitary pituitary JJ cord-014516-r59usk02 938 18 adenomas adenoma NNS cord-014516-r59usk02 938 19 are be VBP cord-014516-r59usk02 938 20 caused cause VBN cord-014516-r59usk02 938 21 by by IN cord-014516-r59usk02 938 22 germline germline JJ cord-014516-r59usk02 938 23 mutations mutation NNS cord-014516-r59usk02 938 24 of of IN cord-014516-r59usk02 938 25 the the DT cord-014516-r59usk02 938 26 aryl aryl NN cord-014516-r59usk02 938 27 - - HYPH cord-014516-r59usk02 938 28 hydrocarbon hydrocarbon NN cord-014516-r59usk02 938 29 - - HYPH cord-014516-r59usk02 938 30 receptor receptor NN cord-014516-r59usk02 938 31 interacting interact VBG cord-014516-r59usk02 938 32 protein protein NN cord-014516-r59usk02 938 33 ( ( -LRB- cord-014516-r59usk02 938 34 AIP AIP NNP cord-014516-r59usk02 938 35 ) ) -RRB- cord-014516-r59usk02 938 36 . . . cord-014516-r59usk02 939 1 Feline feline JJ cord-014516-r59usk02 939 2 acromegaly acromegaly NN cord-014516-r59usk02 939 3 has have VBZ cord-014516-r59usk02 939 4 phenotypic phenotypic JJ cord-014516-r59usk02 939 5 and and CC cord-014516-r59usk02 939 6 biochemical biochemical JJ cord-014516-r59usk02 939 7 similarities similarity NNS cord-014516-r59usk02 939 8 to to IN cord-014516-r59usk02 939 9 human human JJ cord-014516-r59usk02 939 10 familial familial JJ cord-014516-r59usk02 939 11 acromegaly acromegaly NN cord-014516-r59usk02 939 12 with with IN cord-014516-r59usk02 939 13 AIP AIP NNP cord-014516-r59usk02 939 14 mutations mutation NNS cord-014516-r59usk02 939 15 , , , cord-014516-r59usk02 939 16 such such JJ cord-014516-r59usk02 939 17 as as IN cord-014516-r59usk02 939 18 male male JJ cord-014516-r59usk02 939 19 predominance predominance NN cord-014516-r59usk02 939 20 , , , cord-014516-r59usk02 939 21 somatotroph somatotroph NNP cord-014516-r59usk02 939 22 macroadenoma macroadenoma NN cord-014516-r59usk02 939 23 and and CC cord-014516-r59usk02 939 24 resistance resistance NN cord-014516-r59usk02 939 25 to to IN cord-014516-r59usk02 939 26 octreotide octreotide NN cord-014516-r59usk02 939 27 therapy therapy NN cord-014516-r59usk02 939 28 . . . cord-014516-r59usk02 940 1 The the DT cord-014516-r59usk02 940 2 objective objective NN cord-014516-r59usk02 940 3 of of IN cord-014516-r59usk02 940 4 this this DT cord-014516-r59usk02 940 5 study study NN cord-014516-r59usk02 940 6 was be VBD cord-014516-r59usk02 940 7 to to TO cord-014516-r59usk02 940 8 identify identify VB cord-014516-r59usk02 940 9 the the DT cord-014516-r59usk02 940 10 feline feline JJ cord-014516-r59usk02 940 11 AIP AIP NNP cord-014516-r59usk02 940 12 gene gene NN cord-014516-r59usk02 940 13 , , , cord-014516-r59usk02 940 14 identify identify VB cord-014516-r59usk02 940 15 single single JJ cord-014516-r59usk02 940 16 nucleotide nucleotide JJ cord-014516-r59usk02 940 17 polymorphisms polymorphism NNS cord-014516-r59usk02 940 18 ( ( -LRB- cord-014516-r59usk02 940 19 SNPs SNPs NNP cord-014516-r59usk02 940 20 ) ) -RRB- cord-014516-r59usk02 940 21 within within IN cord-014516-r59usk02 940 22 this this DT cord-014516-r59usk02 940 23 gene gene NN cord-014516-r59usk02 940 24 and and CC cord-014516-r59usk02 940 25 compare compare VBP cord-014516-r59usk02 940 26 any any DT cord-014516-r59usk02 940 27 SNPs SNPs NNPS cord-014516-r59usk02 940 28 with with IN cord-014516-r59usk02 940 29 reported report VBN cord-014516-r59usk02 940 30 human human JJ cord-014516-r59usk02 940 31 AIP AIP NNP cord-014516-r59usk02 940 32 SNPs SNPs NNPS cord-014516-r59usk02 940 33 . . . cord-014516-r59usk02 941 1 Stored store VBN cord-014516-r59usk02 941 2 pituitary pituitary JJ cord-014516-r59usk02 941 3 tissue tissue NN cord-014516-r59usk02 941 4 from from IN cord-014516-r59usk02 941 5 an an DT cord-014516-r59usk02 941 6 acromegalic acromegalic JJ cord-014516-r59usk02 941 7 cat cat NN cord-014516-r59usk02 941 8 was be VBD cord-014516-r59usk02 941 9 used use VBN cord-014516-r59usk02 941 10 to to TO cord-014516-r59usk02 941 11 create create VB cord-014516-r59usk02 941 12 feline feline JJ cord-014516-r59usk02 941 13 AIP AIP NNP cord-014516-r59usk02 941 14 cDNA cdna NN cord-014516-r59usk02 941 15 using use VBG cord-014516-r59usk02 941 16 feline feline JJ cord-014516-r59usk02 941 17 specific specific JJ cord-014516-r59usk02 941 18 AIP AIP NNP cord-014516-r59usk02 941 19 primers primer NNS cord-014516-r59usk02 941 20 . . . cord-014516-r59usk02 942 1 Stored store VBN cord-014516-r59usk02 942 2 EDTA EDTA NNP cord-014516-r59usk02 942 3 blood blood NN cord-014516-r59usk02 942 4 from from IN cord-014516-r59usk02 942 5 10 10 CD cord-014516-r59usk02 942 6 acromegalic acromegalic JJ cord-014516-r59usk02 942 7 cats cat NNS cord-014516-r59usk02 942 8 ( ( -LRB- cord-014516-r59usk02 942 9 diagnosis diagnosis NN cord-014516-r59usk02 942 10 of of IN cord-014516-r59usk02 942 11 insulin insulin NN cord-014516-r59usk02 942 12 resistant resistant JJ cord-014516-r59usk02 942 13 diabetes diabetes NN cord-014516-r59usk02 942 14 mellitus mellitus NN cord-014516-r59usk02 942 15 , , , cord-014516-r59usk02 942 16 serum serum NN cord-014516-r59usk02 942 17 IGF-1 IGF-1 NNP cord-014516-r59usk02 942 18 > > XX cord-014516-r59usk02 942 19 1000 1000 CD cord-014516-r59usk02 942 20 ng ng NN cord-014516-r59usk02 942 21 / / SYM cord-014516-r59usk02 942 22 ml ml NN cord-014516-r59usk02 942 23 and and CC cord-014516-r59usk02 942 24 pituitary pituitary JJ cord-014516-r59usk02 942 25 mass mass NN cord-014516-r59usk02 943 1 > > XX cord-014516-r59usk02 943 2 4 4 CD cord-014516-r59usk02 943 3 mm mm NNP cord-014516-r59usk02 943 4 identified identify VBN cord-014516-r59usk02 943 5 using use VBG cord-014516-r59usk02 943 6 pituitary pituitary NN cord-014516-r59usk02 943 7 computed compute VBN cord-014516-r59usk02 943 8 tomography tomography NN cord-014516-r59usk02 943 9 or or CC cord-014516-r59usk02 943 10 necropsy necropsy JJ cord-014516-r59usk02 943 11 ) ) -RRB- cord-014516-r59usk02 943 12 and and CC cord-014516-r59usk02 943 13 10 10 CD cord-014516-r59usk02 943 14 control control NN cord-014516-r59usk02 943 15 cats cat NNS cord-014516-r59usk02 943 16 ( ( -LRB- cord-014516-r59usk02 943 17 no no DT cord-014516-r59usk02 943 18 history history NN cord-014516-r59usk02 943 19 of of IN cord-014516-r59usk02 943 20 diabetes diabetes NN cord-014516-r59usk02 943 21 mellitus mellitus NN cord-014516-r59usk02 943 22 and and CC cord-014516-r59usk02 943 23 greater great JJR cord-014516-r59usk02 943 24 than than IN cord-014516-r59usk02 943 25 15 15 CD cord-014516-r59usk02 943 26 years year NNS cord-014516-r59usk02 943 27 of of IN cord-014516-r59usk02 943 28 age age NN cord-014516-r59usk02 943 29 ) ) -RRB- cord-014516-r59usk02 943 30 were be VBD cord-014516-r59usk02 943 31 selected select VBN cord-014516-r59usk02 943 32 , , , cord-014516-r59usk02 943 33 DNA DNA NNP cord-014516-r59usk02 943 34 extracted extract VBD cord-014516-r59usk02 943 35 and and CC cord-014516-r59usk02 943 36 genotyped genotype VBN cord-014516-r59usk02 943 37 using use VBG cord-014516-r59usk02 943 38 PCR PCR NNP cord-014516-r59usk02 943 39 , , , cord-014516-r59usk02 943 40 agarose agarose JJ cord-014516-r59usk02 943 41 gel gel NN cord-014516-r59usk02 943 42 electrophoresis electrophoresis NN cord-014516-r59usk02 943 43 and and CC cord-014516-r59usk02 943 44 Sanger Sanger NNP cord-014516-r59usk02 943 45 sequencing sequencing NN cord-014516-r59usk02 943 46 . . . cord-014516-r59usk02 944 1 The the DT cord-014516-r59usk02 944 2 feline feline JJ cord-014516-r59usk02 944 3 AIP AIP NNP cord-014516-r59usk02 944 4 gene gene NN cord-014516-r59usk02 944 5 was be VBD cord-014516-r59usk02 944 6 identified identify VBN cord-014516-r59usk02 944 7 , , , cord-014516-r59usk02 944 8 encoding encode VBG cord-014516-r59usk02 944 9 a a DT cord-014516-r59usk02 944 10 330 330 CD cord-014516-r59usk02 944 11 amino amino NN cord-014516-r59usk02 944 12 acid acid NN cord-014516-r59usk02 944 13 protein protein NN cord-014516-r59usk02 944 14 with with IN cord-014516-r59usk02 944 15 98 98 CD cord-014516-r59usk02 944 16 % % NN cord-014516-r59usk02 944 17 homology homology NN cord-014516-r59usk02 944 18 to to IN cord-014516-r59usk02 944 19 the the DT cord-014516-r59usk02 944 20 human human JJ cord-014516-r59usk02 944 21 AIP AIP NNP cord-014516-r59usk02 944 22 protein protein NN cord-014516-r59usk02 944 23 . . . cord-014516-r59usk02 945 1 A a DT cord-014516-r59usk02 945 2 BLAST blast NN cord-014516-r59usk02 945 3 search search NN cord-014516-r59usk02 945 4 revealed reveal VBD cord-014516-r59usk02 945 5 this this DT cord-014516-r59usk02 945 6 gene gene NN cord-014516-r59usk02 945 7 contained contain VBD cord-014516-r59usk02 945 8 6 6 CD cord-014516-r59usk02 945 9 exons exon NNS cord-014516-r59usk02 945 10 and and CC cord-014516-r59usk02 945 11 exon exon JJ cord-014516-r59usk02 945 12 specific specific JJ cord-014516-r59usk02 945 13 primers primer NNS cord-014516-r59usk02 945 14 were be VBD cord-014516-r59usk02 945 15 created create VBN cord-014516-r59usk02 945 16 to to TO cord-014516-r59usk02 945 17 enable enable VB cord-014516-r59usk02 945 18 sequencing sequencing NN cord-014516-r59usk02 945 19 . . . cord-014516-r59usk02 946 1 A a DT cord-014516-r59usk02 946 2 single single JJ cord-014516-r59usk02 946 3 nonconservative nonconservative JJ cord-014516-r59usk02 946 4 SNP SNP NNP cord-014516-r59usk02 946 5 was be VBD cord-014516-r59usk02 946 6 identified identify VBN cord-014516-r59usk02 946 7 in in IN cord-014516-r59usk02 946 8 exon exon NN cord-014516-r59usk02 946 9 1 1 CD cord-014516-r59usk02 946 10 ( ( -LRB- cord-014516-r59usk02 946 11 AIP aip NN cord-014516-r59usk02 946 12 : : : cord-014516-r59usk02 946 13 c.9G c.9g NN cord-014516-r59usk02 946 14 > > XX cord-014516-r59usk02 946 15 T T NNP cord-014516-r59usk02 946 16 ) ) -RRB- cord-014516-r59usk02 946 17 , , , cord-014516-r59usk02 946 18 encoding encode VBG cord-014516-r59usk02 946 19 for for IN cord-014516-r59usk02 946 20 an an DT cord-014516-r59usk02 946 21 amino amino NN cord-014516-r59usk02 946 22 acid acid NN cord-014516-r59usk02 946 23 change change NN cord-014516-r59usk02 946 24 from from IN cord-014516-r59usk02 946 25 aspartic aspartic JJ cord-014516-r59usk02 946 26 acid acid NN cord-014516-r59usk02 946 27 to to IN cord-014516-r59usk02 946 28 glutamic glutamic NN cord-014516-r59usk02 946 29 acid acid NN cord-014516-r59usk02 946 30 in in IN cord-014516-r59usk02 946 31 2/10 2/10 CD cord-014516-r59usk02 946 32 acromegalic acromegalic JJ cord-014516-r59usk02 946 33 patients patient NNS cord-014516-r59usk02 946 34 and and CC cord-014516-r59usk02 946 35 0/10 0/10 CD cord-014516-r59usk02 946 36 control control NN cord-014516-r59usk02 946 37 cats cat NNS cord-014516-r59usk02 946 38 . . . cord-014516-r59usk02 947 1 Two two CD cord-014516-r59usk02 947 2 additional additional JJ cord-014516-r59usk02 947 3 conservative conservative JJ cord-014516-r59usk02 947 4 SNPs snp NNS cord-014516-r59usk02 947 5 were be VBD cord-014516-r59usk02 947 6 also also RB cord-014516-r59usk02 947 7 identified identify VBN cord-014516-r59usk02 947 8 ( ( -LRB- cord-014516-r59usk02 947 9 AIP aip NN cord-014516-r59usk02 947 10 : : : cord-014516-r59usk02 947 11 c.826 c.826 NNP cord-014516-r59usk02 947 12 T t NN cord-014516-r59usk02 948 1 > > XX cord-014516-r59usk02 949 1 C C NNP cord-014516-r59usk02 949 2 and and CC cord-014516-r59usk02 949 3 AIP AIP NNP cord-014516-r59usk02 949 4 : : : cord-014516-r59usk02 949 5 c.481 c.481 NNP cord-014516-r59usk02 949 6 T T NNP cord-014516-r59usk02 950 1 > > XX cord-014516-r59usk02 950 2 C C NNP cord-014516-r59usk02 950 3 ) ) -RRB- cord-014516-r59usk02 950 4 . . . cord-014516-r59usk02 951 1 Exon exon NN cord-014516-r59usk02 951 2 1 1 CD cord-014516-r59usk02 951 3 encodes encode VBZ cord-014516-r59usk02 951 4 for for IN cord-014516-r59usk02 951 5 a a DT cord-014516-r59usk02 951 6 region region NN cord-014516-r59usk02 951 7 of of IN cord-014516-r59usk02 951 8 the the DT cord-014516-r59usk02 951 9 AIP AIP NNP cord-014516-r59usk02 951 10 protein protein NN cord-014516-r59usk02 951 11 considered consider VBD cord-014516-r59usk02 951 12 essential essential JJ cord-014516-r59usk02 951 13 for for IN cord-014516-r59usk02 951 14 AIP AIP NNP cord-014516-r59usk02 951 15 - - HYPH cord-014516-r59usk02 951 16 AIP AIP NNP cord-014516-r59usk02 951 17 receptor receptor NN cord-014516-r59usk02 951 18 interaction interaction NN cord-014516-r59usk02 951 19 . . . cord-014516-r59usk02 952 1 Although although IN cord-014516-r59usk02 952 2 70 70 CD cord-014516-r59usk02 952 3 different different JJ cord-014516-r59usk02 952 4 human human NN cord-014516-r59usk02 952 5 AIP aip NN cord-014516-r59usk02 952 6 mutations mutation NNS cord-014516-r59usk02 952 7 have have VBP cord-014516-r59usk02 952 8 been be VBN cord-014516-r59usk02 952 9 identified identify VBN cord-014516-r59usk02 952 10 to to IN cord-014516-r59usk02 952 11 date date NN cord-014516-r59usk02 952 12 , , , cord-014516-r59usk02 952 13 a a DT cord-014516-r59usk02 952 14 human human JJ cord-014516-r59usk02 952 15 AIP aip NN cord-014516-r59usk02 952 16 : : : cord-014516-r59usk02 953 1 c9G c9G NNP cord-014516-r59usk02 953 2 > > XX cord-014516-r59usk02 953 3 T t NN cord-014516-r59usk02 953 4 mutation mutation NN cord-014516-r59usk02 953 5 has have VBZ cord-014516-r59usk02 953 6 not not RB cord-014516-r59usk02 953 7 yet yet RB cord-014516-r59usk02 953 8 been be VBN cord-014516-r59usk02 953 9 identified identify VBN cord-014516-r59usk02 953 10 . . . cord-014516-r59usk02 954 1 The the DT cord-014516-r59usk02 954 2 AIP AIP NNP cord-014516-r59usk02 954 3 N N NNP cord-014516-r59usk02 954 4 - - HYPH cord-014516-r59usk02 954 5 terminal terminal NN cord-014516-r59usk02 954 6 is be VBZ cord-014516-r59usk02 954 7 required require VBN cord-014516-r59usk02 954 8 for for IN cord-014516-r59usk02 954 9 the the DT cord-014516-r59usk02 954 10 stability stability NN cord-014516-r59usk02 954 11 of of IN cord-014516-r59usk02 954 12 the the DT cord-014516-r59usk02 954 13 AIP AIP NNP cord-014516-r59usk02 954 14 protein protein NN cord-014516-r59usk02 954 15 - - HYPH cord-014516-r59usk02 954 16 AIP aip NN cord-014516-r59usk02 954 17 - - HYPH cord-014516-r59usk02 954 18 receptor receptor NN cord-014516-r59usk02 954 19 complex complex NN cord-014516-r59usk02 954 20 , , , cord-014516-r59usk02 954 21 and and CC cord-014516-r59usk02 954 22 essential essential JJ cord-014516-r59usk02 954 23 for for IN cord-014516-r59usk02 954 24 the the DT cord-014516-r59usk02 954 25 regulation regulation NN cord-014516-r59usk02 954 26 of of IN cord-014516-r59usk02 954 27 translocation translocation NN cord-014516-r59usk02 954 28 into into IN cord-014516-r59usk02 954 29 the the DT cord-014516-r59usk02 954 30 nucleus nucleus NN cord-014516-r59usk02 954 31 , , , cord-014516-r59usk02 954 32 where where WRB cord-014516-r59usk02 954 33 it -PRON- PRP cord-014516-r59usk02 954 34 binds bind VBZ cord-014516-r59usk02 954 35 to to IN cord-014516-r59usk02 954 36 aryl aryl NN cord-014516-r59usk02 954 37 hydrocarbon hydrocarbon NN cord-014516-r59usk02 954 38 receptor receptor NN cord-014516-r59usk02 954 39 nuclear nuclear JJ cord-014516-r59usk02 954 40 translocator translocator NN cord-014516-r59usk02 954 41 leading lead VBG cord-014516-r59usk02 954 42 to to IN cord-014516-r59usk02 954 43 activation activation NN cord-014516-r59usk02 954 44 of of IN cord-014516-r59usk02 954 45 genes gene NNS cord-014516-r59usk02 954 46 thought think VBN cord-014516-r59usk02 954 47 to to TO cord-014516-r59usk02 954 48 act act VB cord-014516-r59usk02 954 49 as as IN cord-014516-r59usk02 954 50 tumor tumor NN cord-014516-r59usk02 954 51 suppressors suppressor NNS cord-014516-r59usk02 954 52 . . . cord-014516-r59usk02 955 1 Loss loss NN cord-014516-r59usk02 955 2 of of IN cord-014516-r59usk02 955 3 normal normal JJ cord-014516-r59usk02 955 4 AIP aip NN cord-014516-r59usk02 955 5 activity activity NN cord-014516-r59usk02 955 6 is be VBZ cord-014516-r59usk02 955 7 thought think VBN cord-014516-r59usk02 955 8 to to TO cord-014516-r59usk02 955 9 promote promote VB cord-014516-r59usk02 955 10 somatotrophinoma somatotrophinoma NNP cord-014516-r59usk02 955 11 development development NN cord-014516-r59usk02 955 12 . . . cord-014516-r59usk02 956 1 It -PRON- PRP cord-014516-r59usk02 956 2 is be VBZ cord-014516-r59usk02 956 3 therefore therefore RB cord-014516-r59usk02 956 4 possible possible JJ cord-014516-r59usk02 956 5 that that IN cord-014516-r59usk02 956 6 the the DT cord-014516-r59usk02 956 7 detected detect VBN cord-014516-r59usk02 956 8 AIP aip NN cord-014516-r59usk02 956 9 : : : cord-014516-r59usk02 956 10 c.9G c.9g NN cord-014516-r59usk02 956 11 > > XX cord-014516-r59usk02 956 12 T t NN cord-014516-r59usk02 956 13 mutation mutation NN cord-014516-r59usk02 956 14 predisposed predispose VBN cord-014516-r59usk02 956 15 to to TO cord-014516-r59usk02 956 16 somatotrophinoma somatotrophinoma NNP cord-014516-r59usk02 956 17 tumorigenesis tumorigenesis NN cord-014516-r59usk02 956 18 in in IN cord-014516-r59usk02 956 19 the the DT cord-014516-r59usk02 956 20 two two CD cord-014516-r59usk02 956 21 affected affect VBN cord-014516-r59usk02 956 22 patients patient NNS cord-014516-r59usk02 956 23 , , , cord-014516-r59usk02 956 24 and and CC cord-014516-r59usk02 956 25 a a DT cord-014516-r59usk02 956 26 study study NN cord-014516-r59usk02 956 27 containing contain VBG cord-014516-r59usk02 956 28 a a DT cord-014516-r59usk02 956 29 larger large JJR cord-014516-r59usk02 956 30 number number NN cord-014516-r59usk02 956 31 of of IN cord-014516-r59usk02 956 32 cases case NNS cord-014516-r59usk02 956 33 is be VBZ cord-014516-r59usk02 956 34 indicated indicate VBN cord-014516-r59usk02 956 35 . . . cord-014516-r59usk02 957 1 No no DT cord-014516-r59usk02 957 2 conflicts conflict NNS cord-014516-r59usk02 957 3 of of IN cord-014516-r59usk02 957 4 interest interest NN cord-014516-r59usk02 957 5 reported report VBN cord-014516-r59usk02 957 6 . . . cord-014516-r59usk02 958 1 Hypersomatotrophism Hypersomatotrophism NNP cord-014516-r59usk02 958 2 ( ( -LRB- cord-014516-r59usk02 958 3 HS HS NNP cord-014516-r59usk02 958 4 ) ) -RRB- cord-014516-r59usk02 958 5 is be VBZ cord-014516-r59usk02 958 6 an an DT cord-014516-r59usk02 958 7 important important JJ cord-014516-r59usk02 958 8 cause cause NN cord-014516-r59usk02 958 9 of of IN cord-014516-r59usk02 958 10 feline feline JJ cord-014516-r59usk02 958 11 diabetes diabetes NN cord-014516-r59usk02 958 12 mellitus mellitus NN cord-014516-r59usk02 958 13 ( ( -LRB- cord-014516-r59usk02 958 14 DM DM NNP cord-014516-r59usk02 958 15 ) ) -RRB- cord-014516-r59usk02 958 16 . . . cord-014516-r59usk02 959 1 In in IN cord-014516-r59usk02 959 2 humans human NNS cord-014516-r59usk02 959 3 surgical surgical JJ cord-014516-r59usk02 959 4 removal removal NN cord-014516-r59usk02 959 5 of of IN cord-014516-r59usk02 959 6 the the DT cord-014516-r59usk02 959 7 somatotrophinoma somatotrophinoma NNP cord-014516-r59usk02 959 8 is be VBZ cord-014516-r59usk02 959 9 generally generally RB cord-014516-r59usk02 959 10 recommended recommend VBN cord-014516-r59usk02 959 11 , , , cord-014516-r59usk02 959 12 though though IN cord-014516-r59usk02 959 13 hypophysectomy hypophysectomy NN cord-014516-r59usk02 959 14 programs program NNS cord-014516-r59usk02 959 15 have have VBP cord-014516-r59usk02 959 16 suffered suffer VBN cord-014516-r59usk02 959 17 from from IN cord-014516-r59usk02 959 18 significant significant JJ cord-014516-r59usk02 959 19 initial initial JJ cord-014516-r59usk02 959 20 morbidity morbidity NN cord-014516-r59usk02 959 21 and and CC cord-014516-r59usk02 959 22 mortality mortality NN cord-014516-r59usk02 959 23 given give VBN cord-014516-r59usk02 959 24 a a DT cord-014516-r59usk02 959 25 documented document VBN cord-014516-r59usk02 959 26 steep steep JJ cord-014516-r59usk02 959 27 learning learning NN cord-014516-r59usk02 959 28 curve curve NN cord-014516-r59usk02 959 29 in in IN cord-014516-r59usk02 959 30 newly newly RB cord-014516-r59usk02 959 31 established establish VBN cord-014516-r59usk02 959 32 programs program NNS cord-014516-r59usk02 959 33 . . . cord-014516-r59usk02 960 1 Hypophysectomy Hypophysectomy NNP cord-014516-r59usk02 960 2 as as IN cord-014516-r59usk02 960 3 treatment treatment NN cord-014516-r59usk02 960 4 for for IN cord-014516-r59usk02 960 5 feline feline JJ cord-014516-r59usk02 960 6 HS HS NNP cord-014516-r59usk02 960 7 has have VBZ cord-014516-r59usk02 960 8 thus thus RB cord-014516-r59usk02 960 9 far far RB cord-014516-r59usk02 960 10 only only RB cord-014516-r59usk02 960 11 been be VBN cord-014516-r59usk02 960 12 described describe VBN cord-014516-r59usk02 960 13 in in IN cord-014516-r59usk02 960 14 a a DT cord-014516-r59usk02 960 15 handful handful NN cord-014516-r59usk02 960 16 of of IN cord-014516-r59usk02 960 17 cases case NNS cord-014516-r59usk02 960 18 , , , cord-014516-r59usk02 960 19 all all DT cord-014516-r59usk02 960 20 having have VBG cord-014516-r59usk02 960 21 been be VBN cord-014516-r59usk02 960 22 treated treat VBN cord-014516-r59usk02 960 23 by by IN cord-014516-r59usk02 960 24 one one CD cord-014516-r59usk02 960 25 single single JJ cord-014516-r59usk02 960 26 experienced experience VBN cord-014516-r59usk02 960 27 hypophysectomy hypophysectomy NNP cord-014516-r59usk02 960 28 team team NN cord-014516-r59usk02 960 29 . . . cord-014516-r59usk02 961 1 This this DT cord-014516-r59usk02 961 2 study study NN cord-014516-r59usk02 961 3 's 's POS cord-014516-r59usk02 961 4 aim aim NN cord-014516-r59usk02 961 5 was be VBD cord-014516-r59usk02 961 6 to to TO cord-014516-r59usk02 961 7 evaluate evaluate VB cord-014516-r59usk02 961 8 the the DT cord-014516-r59usk02 961 9 learning learning NN cord-014516-r59usk02 961 10 curve curve NN cord-014516-r59usk02 961 11 of of IN cord-014516-r59usk02 961 12 a a DT cord-014516-r59usk02 961 13 de de FW cord-014516-r59usk02 961 14 novo novo NNP cord-014516-r59usk02 961 15 established establish VBN cord-014516-r59usk02 961 16 hypophysectomy hypophysectomy NNP cord-014516-r59usk02 961 17 program program NN cord-014516-r59usk02 961 18 , , , cord-014516-r59usk02 961 19 through through IN cord-014516-r59usk02 961 20 analysis analysis NN cord-014516-r59usk02 961 21 of of IN cord-014516-r59usk02 961 22 peri peri NNP cord-014516-r59usk02 961 23 - - HYPH cord-014516-r59usk02 961 24 and and CC cord-014516-r59usk02 961 25 post post JJ cord-014516-r59usk02 961 26 - - JJ cord-014516-r59usk02 961 27 operative operative JJ cord-014516-r59usk02 961 28 morbidity morbidity NN cord-014516-r59usk02 961 29 and and CC cord-014516-r59usk02 961 30 mortality mortality NN cord-014516-r59usk02 961 31 , , , cord-014516-r59usk02 961 32 and and CC cord-014516-r59usk02 961 33 endocrine endocrine JJ cord-014516-r59usk02 961 34 outcomes outcome NNS cord-014516-r59usk02 961 35 in in IN cord-014516-r59usk02 961 36 the the DT cord-014516-r59usk02 961 37 first first JJ cord-014516-r59usk02 961 38 cohort cohort NN cord-014516-r59usk02 961 39 of of IN cord-014516-r59usk02 961 40 cats cat NNS cord-014516-r59usk02 961 41 with with IN cord-014516-r59usk02 961 42 HS HS NNP cord-014516-r59usk02 961 43 treated treat VBD cord-014516-r59usk02 961 44 . . . cord-014516-r59usk02 962 1 From from IN cord-014516-r59usk02 962 2 2012 2012 CD cord-014516-r59usk02 962 3 owners owner NNS cord-014516-r59usk02 962 4 of of IN cord-014516-r59usk02 962 5 diabetic diabetic JJ cord-014516-r59usk02 962 6 cats cat NNS cord-014516-r59usk02 962 7 with with IN cord-014516-r59usk02 962 8 confirmed confirm VBN cord-014516-r59usk02 962 9 HS HS NNP cord-014516-r59usk02 962 10 ( ( -LRB- cord-014516-r59usk02 962 11 IGF-1 IGF-1 NNP cord-014516-r59usk02 962 12 > > XX cord-014516-r59usk02 963 1 1000 1000 CD cord-014516-r59usk02 963 2 ng ng NN cord-014516-r59usk02 963 3 / / SYM cord-014516-r59usk02 963 4 ml ml NN cord-014516-r59usk02 963 5 , , , cord-014516-r59usk02 963 6 pituitary pituitary JJ cord-014516-r59usk02 963 7 mass mass NN cord-014516-r59usk02 963 8 ) ) -RRB- cord-014516-r59usk02 963 9 presented present VBN cord-014516-r59usk02 963 10 at at IN cord-014516-r59usk02 963 11 the the DT cord-014516-r59usk02 963 12 Royal Royal NNP cord-014516-r59usk02 963 13 Veterinary Veterinary NNP cord-014516-r59usk02 963 14 College College NNP cord-014516-r59usk02 963 15 were be VBD cord-014516-r59usk02 963 16 offered offer VBN cord-014516-r59usk02 963 17 hypophysectomy hypophysectomy NN cord-014516-r59usk02 963 18 . . . cord-014516-r59usk02 964 1 All all DT cord-014516-r59usk02 964 2 cats cat NNS cord-014516-r59usk02 964 3 undergoing undergo VBG cord-014516-r59usk02 964 4 surgery surgery NN cord-014516-r59usk02 964 5 were be VBD cord-014516-r59usk02 964 6 operated operate VBN cord-014516-r59usk02 964 7 by by IN cord-014516-r59usk02 964 8 one one CD cord-014516-r59usk02 964 9 neurosurgeon neurosurgeon NN cord-014516-r59usk02 964 10 with with IN cord-014516-r59usk02 964 11 previously previously RB cord-014516-r59usk02 964 12 only only JJ cord-014516-r59usk02 964 13 cadaveric cadaveric JJ cord-014516-r59usk02 964 14 experience experience NN cord-014516-r59usk02 964 15 of of IN cord-014516-r59usk02 964 16 the the DT cord-014516-r59usk02 964 17 procedure procedure NN cord-014516-r59usk02 964 18 , , , cord-014516-r59usk02 964 19 through through IN cord-014516-r59usk02 964 20 an an DT cord-014516-r59usk02 964 21 adapted adapt VBN cord-014516-r59usk02 964 22 transsphenoidal transsphenoidal NNP cord-014516-r59usk02 964 23 approach approach NN cord-014516-r59usk02 964 24 referencing reference VBG cord-014516-r59usk02 964 25 bony bony JJ cord-014516-r59usk02 964 26 landmarks landmark NNS cord-014516-r59usk02 964 27 to to IN cord-014516-r59usk02 964 28 computed compute VBN cord-014516-r59usk02 964 29 tomographic tomographic JJ cord-014516-r59usk02 964 30 scans scan NNS cord-014516-r59usk02 964 31 reconstructed reconstruct VBN cord-014516-r59usk02 964 32 on on IN cord-014516-r59usk02 964 33 neuronavigation neuronavigation NN cord-014516-r59usk02 964 34 software software NN cord-014516-r59usk02 964 35 . . . cord-014516-r59usk02 965 1 The the DT cord-014516-r59usk02 965 2 somatotrophinoma somatotrophinoma NNP cord-014516-r59usk02 965 3 was be VBD cord-014516-r59usk02 965 4 extirpated extirpate VBN cord-014516-r59usk02 965 5 using use VBG cord-014516-r59usk02 965 6 fine fine JJ cord-014516-r59usk02 965 7 surgical surgical JJ cord-014516-r59usk02 965 8 tools tool NNS cord-014516-r59usk02 965 9 . . . cord-014516-r59usk02 966 1 All all DT cord-014516-r59usk02 966 2 cats cat NNS cord-014516-r59usk02 966 3 received receive VBD cord-014516-r59usk02 966 4 intense intense JJ cord-014516-r59usk02 966 5 electrolyte electrolyte NN cord-014516-r59usk02 966 6 and and CC cord-014516-r59usk02 966 7 blood blood NN cord-014516-r59usk02 966 8 pressure pressure NN cord-014516-r59usk02 966 9 monitoring monitoring NN cord-014516-r59usk02 966 10 , , , cord-014516-r59usk02 966 11 peri peri NNP cord-014516-r59usk02 966 12 - - HYPH cord-014516-r59usk02 966 13 and and CC cord-014516-r59usk02 966 14 post post JJ cord-014516-r59usk02 966 15 - - JJ cord-014516-r59usk02 966 16 operative operative JJ cord-014516-r59usk02 966 17 DDAVP DDAVP NNP cord-014516-r59usk02 966 18 and and CC cord-014516-r59usk02 966 19 intravenous intravenous JJ cord-014516-r59usk02 966 20 insulin insulin NN cord-014516-r59usk02 966 21 and and CC cord-014516-r59usk02 966 22 hydrocortisone hydrocortisone NN cord-014516-r59usk02 966 23 infusion infusion NN cord-014516-r59usk02 966 24 , , , cord-014516-r59usk02 966 25 transitioning transition VBG cord-014516-r59usk02 966 26 to to IN cord-014516-r59usk02 966 27 subcutaneous subcutaneous JJ cord-014516-r59usk02 966 28 glargine glargine NN cord-014516-r59usk02 966 29 , , , cord-014516-r59usk02 966 30 conjunctival conjunctival NN cord-014516-r59usk02 966 31 DDAVP DDAVP NNP cord-014516-r59usk02 966 32 , , , cord-014516-r59usk02 966 33 oral oral JJ cord-014516-r59usk02 966 34 hydrocortisone hydrocortisone NN cord-014516-r59usk02 966 35 and and CC cord-014516-r59usk02 966 36 levothyroxine levothyroxine NN cord-014516-r59usk02 966 37 . . . cord-014516-r59usk02 967 1 Between between IN cord-014516-r59usk02 967 2 April April NNP cord-014516-r59usk02 967 3 2012-February 2012-february CD cord-014516-r59usk02 967 4 2014 2014 CD cord-014516-r59usk02 967 5 , , , cord-014516-r59usk02 967 6 12 12 CD cord-014516-r59usk02 967 7 cats cat NNS cord-014516-r59usk02 967 8 underwent undergo VBD cord-014516-r59usk02 967 9 hypophysectomy hypophysectomy NNP cord-014516-r59usk02 967 10 ( ( -LRB- cord-014516-r59usk02 967 11 median median NN cord-014516-r59usk02 967 12 + + CC cord-014516-r59usk02 967 13 range range NN cord-014516-r59usk02 967 14 age age NN cord-014516-r59usk02 967 15 : : : cord-014516-r59usk02 967 16 10.2 10.2 CD cord-014516-r59usk02 967 17 years year NNS cord-014516-r59usk02 967 18 , , , cord-014516-r59usk02 967 19 5.4 5.4 CD cord-014516-r59usk02 967 20 - - SYM cord-014516-r59usk02 967 21 14.8 14.8 CD cord-014516-r59usk02 967 22 ; ; : cord-014516-r59usk02 967 23 IGF-1 igf-1 NN cord-014516-r59usk02 967 24 : : : cord-014516-r59usk02 968 1 1846 1846 CD cord-014516-r59usk02 968 2 ng ng NNP cord-014516-r59usk02 968 3 / / SYM cord-014516-r59usk02 968 4 ml ml NNP cord-014516-r59usk02 968 5 , , , cord-014516-r59usk02 968 6 1138->2000 1138->2000 CD cord-014516-r59usk02 968 7 ; ; : cord-014516-r59usk02 968 8 pituitary pituitary JJ cord-014516-r59usk02 968 9 height height NN cord-014516-r59usk02 968 10 6.2 6.2 CD cord-014516-r59usk02 968 11 mm mm NNP cord-014516-r59usk02 968 12 , , , cord-014516-r59usk02 968 13 4.0 4.0 CD cord-014516-r59usk02 968 14 - - SYM cord-014516-r59usk02 968 15 10.6 10.6 CD cord-014516-r59usk02 968 16 ) ) -RRB- cord-014516-r59usk02 968 17 . . . cord-014516-r59usk02 969 1 All all DT cord-014516-r59usk02 969 2 displayed display VBD cord-014516-r59usk02 969 3 uncontrolled uncontrolled JJ cord-014516-r59usk02 969 4 DM dm NN cord-014516-r59usk02 969 5 due due IN cord-014516-r59usk02 969 6 to to IN cord-014516-r59usk02 969 7 HS HS NNP cord-014516-r59usk02 969 8 ( ( -LRB- cord-014516-r59usk02 969 9 median median JJ cord-014516-r59usk02 969 10 fructosamine fructosamine NN cord-014516-r59usk02 969 11 : : : cord-014516-r59usk02 969 12 619 619 CD cord-014516-r59usk02 969 13 umol umol NNP cord-014516-r59usk02 969 14 / / SYM cord-014516-r59usk02 969 15 l l NN cord-014516-r59usk02 969 16 ) ) -RRB- cord-014516-r59usk02 969 17 ; ; : cord-014516-r59usk02 969 18 none none NN cord-014516-r59usk02 969 19 displayed display VBD cord-014516-r59usk02 969 20 overt overt JJ cord-014516-r59usk02 969 21 central central JJ cord-014516-r59usk02 969 22 neurological neurological JJ cord-014516-r59usk02 969 23 deficits deficit NNS cord-014516-r59usk02 969 24 . . . cord-014516-r59usk02 970 1 Two two CD cord-014516-r59usk02 970 2 cats cat NNS cord-014516-r59usk02 970 3 ( ( -LRB- cord-014516-r59usk02 970 4 17 17 CD cord-014516-r59usk02 970 5 % % NN cord-014516-r59usk02 970 6 , , , cord-014516-r59usk02 970 7 cats cat NNS cord-014516-r59usk02 970 8 7 7 CD cord-014516-r59usk02 970 9 and and CC cord-014516-r59usk02 970 10 8 8 CD cord-014516-r59usk02 970 11 ; ; , cord-014516-r59usk02 970 12 pituitary pituitary JJ cord-014516-r59usk02 970 13 height height NN cord-014516-r59usk02 970 14 ( ( -LRB- cord-014516-r59usk02 970 15 mm mm NNP cord-014516-r59usk02 970 16 ) ) -RRB- cord-014516-r59usk02 970 17 : : : cord-014516-r59usk02 971 1 10.6 10.6 CD cord-014516-r59usk02 971 2 and and CC cord-014516-r59usk02 971 3 6.6 6.6 CD cord-014516-r59usk02 971 4 ) ) -RRB- cord-014516-r59usk02 971 5 required require VBD cord-014516-r59usk02 971 6 mechanical mechanical JJ cord-014516-r59usk02 971 7 ventilation ventilation NN cord-014516-r59usk02 971 8 post post NN cord-014516-r59usk02 971 9 - - JJ cord-014516-r59usk02 971 10 operatively operatively RB cord-014516-r59usk02 971 11 and and CC cord-014516-r59usk02 971 12 both both DT cord-014516-r59usk02 971 13 were be VBD cord-014516-r59usk02 971 14 euthanized euthanize VBN cord-014516-r59usk02 971 15 . . . cord-014516-r59usk02 972 1 Post post JJ cord-014516-r59usk02 972 2 - - JJ cord-014516-r59usk02 972 3 mortem mortem JJ cord-014516-r59usk02 972 4 magnetic magnetic JJ cord-014516-r59usk02 972 5 resonance resonance NN cord-014516-r59usk02 972 6 imaging imaging NN cord-014516-r59usk02 972 7 revealed reveal VBD cord-014516-r59usk02 972 8 brain brain NN cord-014516-r59usk02 972 9 herniation herniation NN cord-014516-r59usk02 972 10 and and CC cord-014516-r59usk02 972 11 cerebral cerebral JJ cord-014516-r59usk02 972 12 ischaemia ischaemia NN cord-014516-r59usk02 972 13 was be VBD cord-014516-r59usk02 972 14 suspected suspect VBN cord-014516-r59usk02 972 15 . . . cord-014516-r59usk02 973 1 One one CD cord-014516-r59usk02 973 2 cat cat NN cord-014516-r59usk02 973 3 suffered suffer VBD cord-014516-r59usk02 973 4 cardiac cardiac JJ cord-014516-r59usk02 973 5 arrest arrest NN cord-014516-r59usk02 973 6 post post NN cord-014516-r59usk02 973 7 - - JJ cord-014516-r59usk02 973 8 operatively operatively RB cord-014516-r59usk02 973 9 at at IN cord-014516-r59usk02 973 10 time time NN cord-014516-r59usk02 973 11 of of IN cord-014516-r59usk02 973 12 jugular jugular NN cord-014516-r59usk02 973 13 catheter catheter NN cord-014516-r59usk02 973 14 placement placement NN cord-014516-r59usk02 973 15 , , , cord-014516-r59usk02 973 16 though though RB cord-014516-r59usk02 973 17 made make VBD cord-014516-r59usk02 973 18 an an DT cord-014516-r59usk02 973 19 uneventful uneventful JJ cord-014516-r59usk02 973 20 recovery recovery NN cord-014516-r59usk02 973 21 . . . cord-014516-r59usk02 974 1 Four four CD cord-014516-r59usk02 974 2 other other JJ cord-014516-r59usk02 974 3 cats cat NNS cord-014516-r59usk02 974 4 developed develop VBD cord-014516-r59usk02 974 5 congestive congestive JJ cord-014516-r59usk02 974 6 heart heart NN cord-014516-r59usk02 974 7 failure failure NN cord-014516-r59usk02 974 8 within within IN cord-014516-r59usk02 974 9 5 5 CD cord-014516-r59usk02 974 10 days day NNS cord-014516-r59usk02 974 11 , , , cord-014516-r59usk02 974 12 which which WDT cord-014516-r59usk02 974 13 was be VBD cord-014516-r59usk02 974 14 successfully successfully RB cord-014516-r59usk02 974 15 treated treat VBN cord-014516-r59usk02 974 16 not not RB cord-014516-r59usk02 974 17 necessitating necessitate VBG cord-014516-r59usk02 974 18 ongoing ongoing JJ cord-014516-r59usk02 974 19 therapy therapy NN cord-014516-r59usk02 974 20 . . . cord-014516-r59usk02 975 1 Temporarily temporarily RB cord-014516-r59usk02 975 2 diminished diminish VBD cord-014516-r59usk02 975 3 tear tear JJ cord-014516-r59usk02 975 4 production production NN cord-014516-r59usk02 975 5 was be VBD cord-014516-r59usk02 975 6 seen see VBN cord-014516-r59usk02 975 7 in in IN cord-014516-r59usk02 975 8 5 5 CD cord-014516-r59usk02 975 9 cats cat NNS cord-014516-r59usk02 975 10 . . . cord-014516-r59usk02 976 1 Seven seven CD cord-014516-r59usk02 976 2 of of IN cord-014516-r59usk02 976 3 the the DT cord-014516-r59usk02 976 4 ten ten CD cord-014516-r59usk02 976 5 surviving survive VBG cord-014516-r59usk02 976 6 cats cat NNS cord-014516-r59usk02 976 7 went go VBD cord-014516-r59usk02 976 8 into into IN cord-014516-r59usk02 976 9 diabetic diabetic JJ cord-014516-r59usk02 976 10 remission remission NN cord-014516-r59usk02 976 11 within within IN cord-014516-r59usk02 976 12 a a DT cord-014516-r59usk02 976 13 median median NN cord-014516-r59usk02 976 14 of of IN cord-014516-r59usk02 976 15 19.7 19.7 CD cord-014516-r59usk02 976 16 days day NNS cord-014516-r59usk02 976 17 ( ( -LRB- cord-014516-r59usk02 976 18 9 9 CD cord-014516-r59usk02 976 19 - - SYM cord-014516-r59usk02 976 20 42 42 CD cord-014516-r59usk02 976 21 ) ) -RRB- cord-014516-r59usk02 976 22 ; ; : cord-014516-r59usk02 976 23 3 3 CD cord-014516-r59usk02 976 24 others other NNS cord-014516-r59usk02 976 25 saw see VBD cord-014516-r59usk02 976 26 reduction reduction NN cord-014516-r59usk02 976 27 of of IN cord-014516-r59usk02 976 28 insulin insulin NN cord-014516-r59usk02 976 29 needs need NNS cord-014516-r59usk02 976 30 by by IN cord-014516-r59usk02 976 31 91 91 CD cord-014516-r59usk02 976 32 % % NN cord-014516-r59usk02 976 33 . . . cord-014516-r59usk02 977 1 Serum serum NN cord-014516-r59usk02 977 2 IGF-1 IGF-1 NNP cord-014516-r59usk02 977 3 normalised normalise VBD cord-014516-r59usk02 977 4 rapidly rapidly RB cord-014516-r59usk02 977 5 and and CC cord-014516-r59usk02 977 6 significantly significantly RB cord-014516-r59usk02 977 7 in in IN cord-014516-r59usk02 977 8 all all DT cord-014516-r59usk02 977 9 but but IN cord-014516-r59usk02 977 10 one one CD cord-014516-r59usk02 977 11 cat cat NN cord-014516-r59usk02 977 12 ( ( -LRB- cord-014516-r59usk02 977 13 median median JJ cord-014516-r59usk02 977 14 serum serum NN cord-014516-r59usk02 977 15 IGF-1 IGF-1 NNP cord-014516-r59usk02 977 16 485 485 CD cord-014516-r59usk02 977 17 ng ng NNP cord-014516-r59usk02 977 18 / / SYM cord-014516-r59usk02 977 19 ml ml NN cord-014516-r59usk02 977 20 within within IN cord-014516-r59usk02 977 21 9 9 CD cord-014516-r59usk02 977 22 days day NNS cord-014516-r59usk02 977 23 ) ) -RRB- cord-014516-r59usk02 977 24 . . . cord-014516-r59usk02 978 1 Persistent persistent JJ cord-014516-r59usk02 978 2 neurological neurological JJ cord-014516-r59usk02 978 3 deficits deficit NNS cord-014516-r59usk02 978 4 or or CC cord-014516-r59usk02 978 5 palatal palatal JJ cord-014516-r59usk02 978 6 wound wound NN cord-014516-r59usk02 978 7 breakdown breakdown NN cord-014516-r59usk02 978 8 were be VBD cord-014516-r59usk02 978 9 not not RB cord-014516-r59usk02 978 10 encountered encounter VBN cord-014516-r59usk02 978 11 . . . cord-014516-r59usk02 979 1 Starting start VBG cord-014516-r59usk02 979 2 a a DT cord-014516-r59usk02 979 3 hypophysectomy hypophysectomy NN cord-014516-r59usk02 979 4 program program NN cord-014516-r59usk02 979 5 to to TO cord-014516-r59usk02 979 6 treat treat VB cord-014516-r59usk02 979 7 feline feline JJ cord-014516-r59usk02 979 8 HS HS NNP cord-014516-r59usk02 979 9 was be VBD cord-014516-r59usk02 979 10 associated associate VBN cord-014516-r59usk02 979 11 with with IN cord-014516-r59usk02 979 12 some some DT cord-014516-r59usk02 979 13 risk risk NN cord-014516-r59usk02 979 14 of of IN cord-014516-r59usk02 979 15 mortality mortality NN cord-014516-r59usk02 979 16 , , , cord-014516-r59usk02 979 17 though though IN cord-014516-r59usk02 979 18 surviving survive VBG cord-014516-r59usk02 979 19 cases case NNS cord-014516-r59usk02 979 20 benefited benefit VBD cord-014516-r59usk02 979 21 from from IN cord-014516-r59usk02 979 22 the the DT cord-014516-r59usk02 979 23 procedure procedure NN cord-014516-r59usk02 979 24 with with IN cord-014516-r59usk02 979 25 a a DT cord-014516-r59usk02 979 26 high high JJ cord-014516-r59usk02 979 27 incidence incidence NN cord-014516-r59usk02 979 28 of of IN cord-014516-r59usk02 979 29 diabetic diabetic JJ cord-014516-r59usk02 979 30 remission remission NN cord-014516-r59usk02 979 31 . . . cord-014516-r59usk02 980 1 No no DT cord-014516-r59usk02 980 2 conflicts conflict NNS cord-014516-r59usk02 980 3 of of IN cord-014516-r59usk02 980 4 interest interest NN cord-014516-r59usk02 980 5 reported report VBN cord-014516-r59usk02 980 6 . . . cord-014516-r59usk02 981 1 Pituitary pituitary JJ cord-014516-r59usk02 981 2 dependent dependent JJ cord-014516-r59usk02 981 3 hypercortisolism hypercortisolism NN cord-014516-r59usk02 981 4 ( ( -LRB- cord-014516-r59usk02 981 5 PDH PDH NNP cord-014516-r59usk02 981 6 ) ) -RRB- cord-014516-r59usk02 981 7 in in IN cord-014516-r59usk02 981 8 dogs dog NNS cord-014516-r59usk02 981 9 is be VBZ cord-014516-r59usk02 981 10 frequently frequently RB cord-014516-r59usk02 981 11 associated associate VBN cord-014516-r59usk02 981 12 with with IN cord-014516-r59usk02 981 13 high high JJ cord-014516-r59usk02 981 14 serum serum NN cord-014516-r59usk02 981 15 phosphate phosphate NN cord-014516-r59usk02 981 16 and and CC cord-014516-r59usk02 981 17 parathormone parathormone NN cord-014516-r59usk02 981 18 concentrations concentration NNS cord-014516-r59usk02 981 19 . . . cord-014516-r59usk02 982 1 The the DT cord-014516-r59usk02 982 2 pathogenesis pathogenesis NN cord-014516-r59usk02 982 3 of of IN cord-014516-r59usk02 982 4 such such JJ cord-014516-r59usk02 982 5 abnormalities abnormality NNS cord-014516-r59usk02 982 6 remains remain VBZ cord-014516-r59usk02 982 7 unknown unknown JJ cord-014516-r59usk02 982 8 and and CC cord-014516-r59usk02 982 9 the the DT cord-014516-r59usk02 982 10 evaluation evaluation NN cord-014516-r59usk02 982 11 of of IN cord-014516-r59usk02 982 12 the the DT cord-014516-r59usk02 982 13 urinary urinary JJ cord-014516-r59usk02 982 14 fractional fractional JJ cord-014516-r59usk02 982 15 excretion excretion NN cord-014516-r59usk02 982 16 of of IN cord-014516-r59usk02 982 17 phosphate phosphate NN cord-014516-r59usk02 982 18 and and CC cord-014516-r59usk02 982 19 calcium calcium NN cord-014516-r59usk02 982 20 in in IN cord-014516-r59usk02 982 21 PDH PDH NNP cord-014516-r59usk02 982 22 dogs dog NNS cord-014516-r59usk02 982 23 might may MD cord-014516-r59usk02 982 24 be be VB cord-014516-r59usk02 982 25 helpful helpful JJ cord-014516-r59usk02 982 26 in in IN cord-014516-r59usk02 982 27 enhancing enhance VBG cord-014516-r59usk02 982 28 the the DT cord-014516-r59usk02 982 29 knowledge knowledge NN cord-014516-r59usk02 982 30 regarding regard VBG cord-014516-r59usk02 982 31 this this DT cord-014516-r59usk02 982 32 issue issue NN cord-014516-r59usk02 982 33 . . . cord-014516-r59usk02 983 1 The the DT cord-014516-r59usk02 983 2 aim aim NN cord-014516-r59usk02 983 3 of of IN cord-014516-r59usk02 983 4 the the DT cord-014516-r59usk02 983 5 present present JJ cord-014516-r59usk02 983 6 study study NN cord-014516-r59usk02 983 7 was be VBD cord-014516-r59usk02 983 8 to to TO cord-014516-r59usk02 983 9 evaluate evaluate VB cord-014516-r59usk02 983 10 the the DT cord-014516-r59usk02 983 11 serum serum NN cord-014516-r59usk02 983 12 and and CC cord-014516-r59usk02 983 13 urinary urinary JJ cord-014516-r59usk02 983 14 concentrations concentration NNS cord-014516-r59usk02 983 15 and and CC cord-014516-r59usk02 983 16 the the DT cord-014516-r59usk02 983 17 urinary urinary JJ cord-014516-r59usk02 983 18 fractional fractional JJ cord-014516-r59usk02 983 19 excretion excretion NN cord-014516-r59usk02 983 20 of of IN cord-014516-r59usk02 983 21 phosphate phosphate NN cord-014516-r59usk02 983 22 and and CC cord-014516-r59usk02 983 23 calcium calcium NN cord-014516-r59usk02 983 24 in in IN cord-014516-r59usk02 983 25 dogs dog NNS cord-014516-r59usk02 983 26 with with IN cord-014516-r59usk02 983 27 PDH PDH NNP cord-014516-r59usk02 983 28 . . . cord-014516-r59usk02 984 1 Medical medical JJ cord-014516-r59usk02 984 2 records record NNS cord-014516-r59usk02 984 3 from from IN cord-014516-r59usk02 984 4 one one CD cord-014516-r59usk02 984 5 referral referral JJ cord-014516-r59usk02 984 6 center center NN cord-014516-r59usk02 984 7 were be VBD cord-014516-r59usk02 984 8 retrospectively retrospectively RB cord-014516-r59usk02 984 9 evaluated evaluate VBN cord-014516-r59usk02 984 10 between between IN cord-014516-r59usk02 984 11 2003 2003 CD cord-014516-r59usk02 984 12 and and CC cord-014516-r59usk02 984 13 2013 2013 CD cord-014516-r59usk02 984 14 . . . cord-014516-r59usk02 985 1 The the DT cord-014516-r59usk02 985 2 diagnosis diagnosis NN cord-014516-r59usk02 985 3 of of IN cord-014516-r59usk02 985 4 PDH PDH NNP cord-014516-r59usk02 985 5 was be VBD cord-014516-r59usk02 985 6 confirmed confirm VBN cord-014516-r59usk02 985 7 using use VBG cord-014516-r59usk02 985 8 the the DT cord-014516-r59usk02 985 9 cortisol cortisol NN cord-014516-r59usk02 985 10 to to IN cord-014516-r59usk02 985 11 creatinine creatinine NN cord-014516-r59usk02 985 12 ratio ratio NN cord-014516-r59usk02 985 13 , , , cord-014516-r59usk02 985 14 the the DT cord-014516-r59usk02 985 15 LDDS LDDS NNP cord-014516-r59usk02 985 16 test test NN cord-014516-r59usk02 985 17 and/or and/or CC cord-014516-r59usk02 985 18 ACTH ACTH NNP cord-014516-r59usk02 985 19 stimulation stimulation NN cord-014516-r59usk02 985 20 test test NN cord-014516-r59usk02 985 21 , , , cord-014516-r59usk02 985 22 the the DT cord-014516-r59usk02 985 23 plasma plasma NN cord-014516-r59usk02 985 24 ACTH ACTH NNP cord-014516-r59usk02 985 25 concentration concentration NN cord-014516-r59usk02 985 26 , , , cord-014516-r59usk02 985 27 ultrasonography ultrasonography NN cord-014516-r59usk02 985 28 of of IN cord-014516-r59usk02 985 29 the the DT cord-014516-r59usk02 985 30 adrenal adrenal JJ cord-014516-r59usk02 985 31 glands gland NNS cord-014516-r59usk02 985 32 and and CC cord-014516-r59usk02 985 33 computer computer NN cord-014516-r59usk02 985 34 tomography tomography NN cord-014516-r59usk02 985 35 ( ( -LRB- cord-014516-r59usk02 985 36 CT CT NNP cord-014516-r59usk02 985 37 ) ) -RRB- cord-014516-r59usk02 985 38 of of IN cord-014516-r59usk02 985 39 the the DT cord-014516-r59usk02 985 40 pituitary pituitary NN cord-014516-r59usk02 985 41 and and CC cord-014516-r59usk02 985 42 the the DT cord-014516-r59usk02 985 43 adrenal adrenal JJ cord-014516-r59usk02 985 44 glands gland NNS cord-014516-r59usk02 985 45 in in IN cord-014516-r59usk02 985 46 dogs dog NNS cord-014516-r59usk02 985 47 with with IN cord-014516-r59usk02 985 48 consistent consistent JJ cord-014516-r59usk02 985 49 clinical clinical JJ cord-014516-r59usk02 985 50 signs sign NNS cord-014516-r59usk02 985 51 . . . cord-014516-r59usk02 986 1 Only only RB cord-014516-r59usk02 986 2 newly newly RB cord-014516-r59usk02 986 3 diagnosed diagnose VBN cord-014516-r59usk02 986 4 dogs dog NNS cord-014516-r59usk02 986 5 , , , cord-014516-r59usk02 986 6 before before IN cord-014516-r59usk02 986 7 treatment treatment NN cord-014516-r59usk02 986 8 for for IN cord-014516-r59usk02 986 9 PDH PDH NNP cord-014516-r59usk02 986 10 , , , cord-014516-r59usk02 986 11 were be VBD cord-014516-r59usk02 986 12 evaluated evaluate VBN cord-014516-r59usk02 986 13 . . . cord-014516-r59usk02 987 1 Two two CD cord-014516-r59usk02 987 2 control control NN cord-014516-r59usk02 987 3 groups group NNS cord-014516-r59usk02 987 4 were be VBD cord-014516-r59usk02 987 5 included include VBN cord-014516-r59usk02 987 6 : : : cord-014516-r59usk02 987 7 one one CD cord-014516-r59usk02 987 8 healthy healthy JJ cord-014516-r59usk02 987 9 and and CC cord-014516-r59usk02 987 10 one one CD cord-014516-r59usk02 987 11 sick sick JJ cord-014516-r59usk02 987 12 control control NN cord-014516-r59usk02 987 13 dog dog NN cord-014516-r59usk02 987 14 ( ( -LRB- cord-014516-r59usk02 987 15 without without IN cord-014516-r59usk02 987 16 PDH PDH NNP cord-014516-r59usk02 987 17 ) ) -RRB- cord-014516-r59usk02 987 18 for for IN cord-014516-r59usk02 987 19 each each DT cord-014516-r59usk02 987 20 dog dog NN cord-014516-r59usk02 987 21 with with IN cord-014516-r59usk02 987 22 PDH PDH NNP cord-014516-r59usk02 987 23 were be VBD cord-014516-r59usk02 987 24 included include VBN cord-014516-r59usk02 987 25 . . . cord-014516-r59usk02 988 1 Healthy healthy JJ cord-014516-r59usk02 988 2 control control NN cord-014516-r59usk02 988 3 dogs dog NNS cord-014516-r59usk02 988 4 ( ( -LRB- cord-014516-r59usk02 988 5 HCD HCD NNP cord-014516-r59usk02 988 6 ) ) -RRB- cord-014516-r59usk02 988 7 and and CC cord-014516-r59usk02 988 8 sick sick JJ cord-014516-r59usk02 988 9 control control NN cord-014516-r59usk02 988 10 dogs dog NNS cord-014516-r59usk02 988 11 ( ( -LRB- cord-014516-r59usk02 988 12 SCD SCD NNP cord-014516-r59usk02 988 13 ) ) -RRB- cord-014516-r59usk02 988 14 were be VBD cord-014516-r59usk02 988 15 matched match VBN cord-014516-r59usk02 988 16 for for IN cord-014516-r59usk02 988 17 age age NN cord-014516-r59usk02 988 18 ( ( -LRB- cord-014516-r59usk02 988 19 AE6 ae6 JJ cord-014516-r59usk02 988 20 months month NNS cord-014516-r59usk02 988 21 ) ) -RRB- cord-014516-r59usk02 988 22 , , , cord-014516-r59usk02 988 23 breed breed NN cord-014516-r59usk02 988 24 , , , cord-014516-r59usk02 988 25 sex sex NN cord-014516-r59usk02 988 26 and and CC cord-014516-r59usk02 988 27 sexual sexual JJ cord-014516-r59usk02 988 28 status status NN cord-014516-r59usk02 988 29 . . . cord-014516-r59usk02 989 1 Data datum NNS cord-014516-r59usk02 989 2 were be VBD cord-014516-r59usk02 989 3 analysed analyse VBN cord-014516-r59usk02 989 4 using use VBG cord-014516-r59usk02 989 5 non non JJ cord-014516-r59usk02 989 6 - - JJ cord-014516-r59usk02 989 7 parametric parametric JJ cord-014516-r59usk02 989 8 tests test NNS cord-014516-r59usk02 989 9 and and CC cord-014516-r59usk02 989 10 expressed express VBD cord-014516-r59usk02 989 11 as as IN cord-014516-r59usk02 989 12 median median NN cord-014516-r59usk02 989 13 and and CC cord-014516-r59usk02 989 14 ranges range NNS cord-014516-r59usk02 989 15 . . . cord-014516-r59usk02 990 1 Significance significance NN cord-014516-r59usk02 990 2 was be VBD cord-014516-r59usk02 990 3 set set VBN cord-014516-r59usk02 990 4 at at IN cord-014516-r59usk02 990 5 p p NN cord-014516-r59usk02 990 6 < < XX cord-014516-r59usk02 990 7 0.05 0.05 CD cord-014516-r59usk02 990 8 . . . cord-014516-r59usk02 991 1 One one CD cord-014516-r59usk02 991 2 - - HYPH cord-014516-r59usk02 991 3 hundredsixty hundredsixty NN cord-014516-r59usk02 991 4 - - HYPH cord-014516-r59usk02 991 5 seven seven CD cord-014516-r59usk02 991 6 dogs dog NNS cord-014516-r59usk02 991 7 with with IN cord-014516-r59usk02 991 8 PDH PDH NNP cord-014516-r59usk02 991 9 were be VBD cord-014516-r59usk02 991 10 eligible eligible JJ cord-014516-r59usk02 991 11 for for IN cord-014516-r59usk02 991 12 inclusion inclusion NN cord-014516-r59usk02 991 13 in in IN cord-014516-r59usk02 991 14 the the DT cord-014516-r59usk02 991 15 study study NN cord-014516-r59usk02 991 16 . . . cord-014516-r59usk02 992 1 The the DT cord-014516-r59usk02 992 2 median median JJ cord-014516-r59usk02 992 3 age age NN cord-014516-r59usk02 992 4 at at IN cord-014516-r59usk02 992 5 diagnosis diagnosis NN cord-014516-r59usk02 992 6 was be VBD cord-014516-r59usk02 992 7 10 10 CD cord-014516-r59usk02 992 8 years year NNS cord-014516-r59usk02 993 1 ( ( -LRB- cord-014516-r59usk02 993 2 range range NN cord-014516-r59usk02 993 3 : : : cord-014516-r59usk02 993 4 3 3 CD cord-014516-r59usk02 993 5 - - SYM cord-014516-r59usk02 993 6 16 16 CD cord-014516-r59usk02 993 7 ) ) -RRB- cord-014516-r59usk02 993 8 and and CC cord-014516-r59usk02 993 9 the the DT cord-014516-r59usk02 993 10 median median JJ cord-014516-r59usk02 993 11 body body NN cord-014516-r59usk02 993 12 weight weight NN cord-014516-r59usk02 993 13 was be VBD cord-014516-r59usk02 993 14 14.7 14.7 CD cord-014516-r59usk02 993 15 kg kg NNS cord-014516-r59usk02 993 16 ( ( -LRB- cord-014516-r59usk02 993 17 range range NN cord-014516-r59usk02 993 18 : : : cord-014516-r59usk02 993 19 3.0 3.0 CD cord-014516-r59usk02 993 20 - - HYPH cord-014516-r59usk02 993 21 65.5 65.5 CD cord-014516-r59usk02 993 22 ) ) -RRB- cord-014516-r59usk02 993 23 . . . cord-014516-r59usk02 994 1 There there EX cord-014516-r59usk02 994 2 were be VBD cord-014516-r59usk02 994 3 100 100 CD cord-014516-r59usk02 994 4 female female JJ cord-014516-r59usk02 994 5 ( ( -LRB- cord-014516-r59usk02 994 6 64 64 CD cord-014516-r59usk02 994 7 spayed spayed JJ cord-014516-r59usk02 994 8 ) ) -RRB- cord-014516-r59usk02 994 9 and and CC cord-014516-r59usk02 994 10 67 67 CD cord-014516-r59usk02 994 11 male male JJ cord-014516-r59usk02 994 12 ( ( -LRB- cord-014516-r59usk02 994 13 11 11 CD cord-014516-r59usk02 994 14 castrated castrate VBN cord-014516-r59usk02 994 15 ) ) -RRB- cord-014516-r59usk02 994 16 . . . cord-014516-r59usk02 995 1 Serum serum NN cord-014516-r59usk02 995 2 phosphate phosphate NN cord-014516-r59usk02 995 3 concentration concentration NN cord-014516-r59usk02 995 4 ( ( -LRB- cord-014516-r59usk02 995 5 4.1 4.1 CD cord-014516-r59usk02 995 6 mg mg NNP cord-014516-r59usk02 995 7 / / SYM cord-014516-r59usk02 995 8 dl dl NNP cord-014516-r59usk02 995 9 , , , cord-014516-r59usk02 995 10 1.3 1.3 CD cord-014516-r59usk02 995 11 - - SYM cord-014516-r59usk02 995 12 10.7 10.7 CD cord-014516-r59usk02 995 13 ) ) -RRB- cord-014516-r59usk02 995 14 was be VBD cord-014516-r59usk02 995 15 significantly significantly RB cord-014516-r59usk02 995 16 ( ( -LRB- cord-014516-r59usk02 995 17 p p NN cord-014516-r59usk02 995 18 < < XX cord-014516-r59usk02 995 19 0.0001 0.0001 CD cord-014516-r59usk02 995 20 ) ) -RRB- cord-014516-r59usk02 995 21 higher high JJR cord-014516-r59usk02 995 22 compared compare VBN cord-014516-r59usk02 995 23 to to IN cord-014516-r59usk02 995 24 HCD HCD NNP cord-014516-r59usk02 995 25 ( ( -LRB- cord-014516-r59usk02 995 26 3.4 3.4 CD cord-014516-r59usk02 995 27 mg mg NNP cord-014516-r59usk02 995 28 / / SYM cord-014516-r59usk02 995 29 dl dl NNP cord-014516-r59usk02 995 30 , , , cord-014516-r59usk02 995 31 1.3 1.3 CD cord-014516-r59usk02 995 32 - - SYM cord-014516-r59usk02 995 33 5.2 5.2 CD cord-014516-r59usk02 995 34 ) ) -RRB- cord-014516-r59usk02 995 35 and and CC cord-014516-r59usk02 995 36 SCD SCD NNP cord-014516-r59usk02 995 37 ( ( -LRB- cord-014516-r59usk02 995 38 3.8 3.8 CD cord-014516-r59usk02 995 39 mg mg NNP cord-014516-r59usk02 995 40 / / SYM cord-014516-r59usk02 995 41 dl dl NNP cord-014516-r59usk02 995 42 , , , cord-014516-r59usk02 995 43 1.1 1.1 CD cord-014516-r59usk02 995 44 - - SYM cord-014516-r59usk02 995 45 32.1 32.1 CD cord-014516-r59usk02 995 46 ) ) -RRB- cord-014516-r59usk02 995 47 . . . cord-014516-r59usk02 996 1 Serum serum NN cord-014516-r59usk02 996 2 calcium calcium NN cord-014516-r59usk02 996 3 concentration concentration NN cord-014516-r59usk02 996 4 ( ( -LRB- cord-014516-r59usk02 996 5 10.4 10.4 CD cord-014516-r59usk02 996 6 mg mg NNP cord-014516-r59usk02 996 7 / / SYM cord-014516-r59usk02 996 8 dl dl NNP cord-014516-r59usk02 996 9 , , , cord-014516-r59usk02 996 10 7.0 7.0 CD cord-014516-r59usk02 996 11 - - SYM cord-014516-r59usk02 996 12 14.5 14.5 CD cord-014516-r59usk02 996 13 ) ) -RRB- cord-014516-r59usk02 996 14 was be VBD cord-014516-r59usk02 996 15 significantly significantly RB cord-014516-r59usk02 996 16 higher high JJR cord-014516-r59usk02 996 17 compared compare VBN cord-014516-r59usk02 996 18 to to IN cord-014516-r59usk02 996 19 SCD SCD NNP cord-014516-r59usk02 996 20 ( ( -LRB- cord-014516-r59usk02 996 21 10.1 10.1 CD cord-014516-r59usk02 996 22 mg mg NNP cord-014516-r59usk02 996 23 / / SYM cord-014516-r59usk02 996 24 dl dl NNP cord-014516-r59usk02 996 25 , , , cord-014516-r59usk02 996 26 5.5 5.5 CD cord-014516-r59usk02 996 27 - - HYPH cord-014516-r59usk02 996 28 12.9 12.9 CD cord-014516-r59usk02 996 29 ) ) -RRB- cord-014516-r59usk02 996 30 but but CC cord-014516-r59usk02 996 31 not not RB cord-014516-r59usk02 996 32 different different JJ cord-014516-r59usk02 996 33 compared compare VBN cord-014516-r59usk02 996 34 to to IN cord-014516-r59usk02 996 35 HCD HCD NNP cord-014516-r59usk02 996 36 ( ( -LRB- cord-014516-r59usk02 996 37 10.2 10.2 CD cord-014516-r59usk02 996 38 mg mg NNP cord-014516-r59usk02 996 39 / / SYM cord-014516-r59usk02 996 40 dl dl NNP cord-014516-r59usk02 996 41 , , , cord-014516-r59usk02 996 42 8.9 8.9 CD cord-014516-r59usk02 996 43 - - SYM cord-014516-r59usk02 996 44 12.0 12.0 CD cord-014516-r59usk02 996 45 ) ) -RRB- cord-014516-r59usk02 996 46 . . . cord-014516-r59usk02 997 1 Urinary urinary JJ cord-014516-r59usk02 997 2 fractional fractional JJ cord-014516-r59usk02 997 3 excretion excretion NN cord-014516-r59usk02 997 4 of of IN cord-014516-r59usk02 997 5 phosphate phosphate NN cord-014516-r59usk02 997 6 ( ( -LRB- cord-014516-r59usk02 997 7 15.5 15.5 CD cord-014516-r59usk02 997 8 % % NN cord-014516-r59usk02 997 9 , , , cord-014516-r59usk02 997 10 0.5 0.5 CD cord-014516-r59usk02 997 11 - - HYPH cord-014516-r59usk02 997 12 65.1 65.1 CD cord-014516-r59usk02 997 13 ) ) -RRB- cord-014516-r59usk02 997 14 was be VBD cord-014516-r59usk02 997 15 significantly significantly RB cord-014516-r59usk02 997 16 lower low JJR cord-014516-r59usk02 997 17 compared compare VBN cord-014516-r59usk02 997 18 to to IN cord-014516-r59usk02 997 19 HCD HCD NNP cord-014516-r59usk02 997 20 ( ( -LRB- cord-014516-r59usk02 997 21 20.4 20.4 CD cord-014516-r59usk02 997 22 % % NN cord-014516-r59usk02 997 23 , , , cord-014516-r59usk02 997 24 0.4 0.4 CD cord-014516-r59usk02 997 25 - - HYPH cord-014516-r59usk02 997 26 67.9 67.9 CD cord-014516-r59usk02 997 27 ) ) -RRB- cord-014516-r59usk02 997 28 and and CC cord-014516-r59usk02 997 29 SCD SCD NNP cord-014516-r59usk02 997 30 ( ( -LRB- cord-014516-r59usk02 997 31 16.9 16.9 CD cord-014516-r59usk02 997 32 % % NN cord-014516-r59usk02 997 33 , , , cord-014516-r59usk02 997 34 0 0 CD cord-014516-r59usk02 997 35 - - HYPH cord-014516-r59usk02 997 36 83.6 83.6 CD cord-014516-r59usk02 997 37 ) ) -RRB- cord-014516-r59usk02 997 38 . . . cord-014516-r59usk02 998 1 Urinary urinary JJ cord-014516-r59usk02 998 2 fractional fractional JJ cord-014516-r59usk02 998 3 excretion excretion NN cord-014516-r59usk02 998 4 of of IN cord-014516-r59usk02 998 5 calcium calcium NN cord-014516-r59usk02 998 6 ( ( -LRB- cord-014516-r59usk02 998 7 0.37 0.37 CD cord-014516-r59usk02 998 8 % % NN cord-014516-r59usk02 998 9 , , , cord-014516-r59usk02 998 10 0 0 CD cord-014516-r59usk02 998 11 - - HYPH cord-014516-r59usk02 998 12 5.70 5.70 CD cord-014516-r59usk02 998 13 ) ) -RRB- cord-014516-r59usk02 998 14 was be VBD cord-014516-r59usk02 998 15 significantly significantly RB cord-014516-r59usk02 998 16 higher high JJR cord-014516-r59usk02 998 17 compared compare VBN cord-014516-r59usk02 998 18 to to IN cord-014516-r59usk02 998 19 HCD HCD NNP cord-014516-r59usk02 998 20 ( ( -LRB- cord-014516-r59usk02 998 21 0.22 0.22 CD cord-014516-r59usk02 998 22 % % NN cord-014516-r59usk02 998 23 , , , cord-014516-r59usk02 998 24 0.02 0.02 CD cord-014516-r59usk02 998 25 - - SYM cord-014516-r59usk02 998 26 1.76 1.76 CD cord-014516-r59usk02 998 27 ) ) -RRB- cord-014516-r59usk02 998 28 and and CC cord-014516-r59usk02 998 29 SCD SCD NNP cord-014516-r59usk02 998 30 ( ( -LRB- cord-014516-r59usk02 998 31 0.24 0.24 CD cord-014516-r59usk02 998 32 % % NN cord-014516-r59usk02 998 33 , , , cord-014516-r59usk02 998 34 0 0 CD cord-014516-r59usk02 998 35 - - HYPH cord-014516-r59usk02 998 36 18.71 18.71 CD cord-014516-r59usk02 998 37 ) ) -RRB- cord-014516-r59usk02 998 38 . . . cord-014516-r59usk02 999 1 Urinary urinary JJ cord-014516-r59usk02 999 2 calcium calcium NN cord-014516-r59usk02 999 3 to to IN cord-014516-r59usk02 999 4 creatinine creatinine NN cord-014516-r59usk02 999 5 ratio ratio NN cord-014516-r59usk02 999 6 ( ( -LRB- cord-014516-r59usk02 999 7 4.78 4.78 CD cord-014516-r59usk02 999 8 , , , cord-014516-r59usk02 999 9 0 0 CD cord-014516-r59usk02 999 10 - - SYM cord-014516-r59usk02 999 11 54.50 54.50 CD cord-014516-r59usk02 999 12 ) ) -RRB- cord-014516-r59usk02 999 13 was be VBD cord-014516-r59usk02 999 14 significantly significantly RB cord-014516-r59usk02 999 15 higher high JJR cord-014516-r59usk02 999 16 compared compare VBN cord-014516-r59usk02 999 17 to to IN cord-014516-r59usk02 999 18 HCD HCD NNP cord-014516-r59usk02 999 19 ( ( -LRB- cord-014516-r59usk02 999 20 2.17 2.17 CD cord-014516-r59usk02 999 21 0.20 0.20 CD cord-014516-r59usk02 999 22 - - SYM cord-014516-r59usk02 999 23 16.80 16.80 CD cord-014516-r59usk02 999 24 ) ) -RRB- cord-014516-r59usk02 999 25 and and CC cord-014516-r59usk02 999 26 SCD SCD NNP cord-014516-r59usk02 999 27 ( ( -LRB- cord-014516-r59usk02 999 28 2.38 2.38 CD cord-014516-r59usk02 999 29 , , , cord-014516-r59usk02 999 30 0 0 CD cord-014516-r59usk02 999 31 - - SYM cord-014516-r59usk02 999 32 16.40 16.40 CD cord-014516-r59usk02 999 33 ) ) -RRB- cord-014516-r59usk02 999 34 , , , cord-014516-r59usk02 999 35 while while IN cord-014516-r59usk02 999 36 urinary urinary JJ cord-014516-r59usk02 999 37 phosphate phosphate NN cord-014516-r59usk02 999 38 to to IN cord-014516-r59usk02 999 39 creatinine creatinine NN cord-014516-r59usk02 999 40 ratio ratio NN cord-014516-r59usk02 999 41 were be VBD cord-014516-r59usk02 999 42 not not RB cord-014516-r59usk02 999 43 significantly significantly RB cord-014516-r59usk02 999 44 different different JJ cord-014516-r59usk02 999 45 in in IN cord-014516-r59usk02 999 46 PDH PDH NNP cord-014516-r59usk02 999 47 dogs dog NNS cord-014516-r59usk02 999 48 , , , cord-014516-r59usk02 999 49 HCD HCD NNP cord-014516-r59usk02 999 50 and and CC cord-014516-r59usk02 999 51 SCD SCD NNP cord-014516-r59usk02 999 52 . . . cord-014516-r59usk02 1000 1 In in IN cord-014516-r59usk02 1000 2 conclusion conclusion NN cord-014516-r59usk02 1000 3 PDH pdh NN cord-014516-r59usk02 1000 4 dogs dog NNS cord-014516-r59usk02 1000 5 have have VBP cord-014516-r59usk02 1000 6 lower low JJR cord-014516-r59usk02 1000 7 phosphaturia phosphaturia NNS cord-014516-r59usk02 1000 8 and and CC cord-014516-r59usk02 1000 9 higher high JJR cord-014516-r59usk02 1000 10 calciuria calciuria NNS cord-014516-r59usk02 1000 11 compared compare VBN cord-014516-r59usk02 1000 12 to to TO cord-014516-r59usk02 1000 13 control control VB cord-014516-r59usk02 1000 14 dogs dog NNS cord-014516-r59usk02 1000 15 . . . cord-014516-r59usk02 1001 1 This this DT cord-014516-r59usk02 1001 2 findings finding NNS cord-014516-r59usk02 1001 3 suggest suggest VBP cord-014516-r59usk02 1001 4 that that IN cord-014516-r59usk02 1001 5 , , , cord-014516-r59usk02 1001 6 at at IN cord-014516-r59usk02 1001 7 least least JJS cord-014516-r59usk02 1001 8 in in IN cord-014516-r59usk02 1001 9 part part NN cord-014516-r59usk02 1001 10 , , , cord-014516-r59usk02 1001 11 the the DT cord-014516-r59usk02 1001 12 high high JJ cord-014516-r59usk02 1001 13 serum serum NN cord-014516-r59usk02 1001 14 phosphate phosphate NN cord-014516-r59usk02 1001 15 concentrations concentration NNS cord-014516-r59usk02 1001 16 are be VBP cord-014516-r59usk02 1001 17 related relate VBN cord-014516-r59usk02 1001 18 to to IN cord-014516-r59usk02 1001 19 the the DT cord-014516-r59usk02 1001 20 renal renal JJ cord-014516-r59usk02 1001 21 retention retention NN cord-014516-r59usk02 1001 22 of of IN cord-014516-r59usk02 1001 23 phosphate phosphate NN cord-014516-r59usk02 1001 24 . . . cord-014516-r59usk02 1002 1 No no DT cord-014516-r59usk02 1002 2 conflicts conflict NNS cord-014516-r59usk02 1002 3 of of IN cord-014516-r59usk02 1002 4 interest interest NN cord-014516-r59usk02 1002 5 reported report VBN cord-014516-r59usk02 1002 6 . . . cord-014516-r59usk02 1003 1 Four four CD cord-014516-r59usk02 1003 2 cortisol cortisol NN cord-014516-r59usk02 1003 3 - - HYPH cord-014516-r59usk02 1003 4 based base VBN cord-014516-r59usk02 1003 5 methods method NNS cord-014516-r59usk02 1003 6 of of IN cord-014516-r59usk02 1003 7 monitoring monitor VBG cord-014516-r59usk02 1003 8 trilostane trilostane NNP cord-014516-r59usk02 1003 9 treatment treatment NN cord-014516-r59usk02 1003 10 of of IN cord-014516-r59usk02 1003 11 canine canine JJ cord-014516-r59usk02 1003 12 hyperadrenocorticism hyperadrenocorticism NN cord-014516-r59usk02 1003 13 were be VBD cord-014516-r59usk02 1003 14 compared compare VBN cord-014516-r59usk02 1003 15 to to IN cord-014516-r59usk02 1003 16 the the DT cord-014516-r59usk02 1003 17 results result NNS cord-014516-r59usk02 1003 18 of of IN cord-014516-r59usk02 1003 19 a a DT cord-014516-r59usk02 1003 20 clinical clinical JJ cord-014516-r59usk02 1003 21 scoring scoring NN cord-014516-r59usk02 1003 22 scheme scheme NN cord-014516-r59usk02 1003 23 based base VBN cord-014516-r59usk02 1003 24 on on IN cord-014516-r59usk02 1003 25 an an DT cord-014516-r59usk02 1003 26 owner owner NN cord-014516-r59usk02 1003 27 questionnaire questionnaire NN cord-014516-r59usk02 1003 28 . . . cord-014516-r59usk02 1004 1 Cases case NNS cord-014516-r59usk02 1004 2 of of IN cord-014516-r59usk02 1004 3 canine canine JJ cord-014516-r59usk02 1004 4 hyperadrenocorticism hyperadrenocorticism NN cord-014516-r59usk02 1004 5 that that WDT cord-014516-r59usk02 1004 6 had have VBD cord-014516-r59usk02 1004 7 received receive VBN cord-014516-r59usk02 1004 8 a a DT cord-014516-r59usk02 1004 9 consistent consistent JJ cord-014516-r59usk02 1004 10 dose dose NN cord-014516-r59usk02 1004 11 of of IN cord-014516-r59usk02 1004 12 trilostane trilostane NNP cord-014516-r59usk02 1004 13 for for IN cord-014516-r59usk02 1004 14 more more JJR cord-014516-r59usk02 1004 15 than than IN cord-014516-r59usk02 1004 16 one one CD cord-014516-r59usk02 1004 17 month month NN cord-014516-r59usk02 1004 18 were be VBD cord-014516-r59usk02 1004 19 recruited recruit VBN cord-014516-r59usk02 1004 20 from from IN cord-014516-r59usk02 1004 21 first first JJ cord-014516-r59usk02 1004 22 opinion opinion NN cord-014516-r59usk02 1004 23 and and CC cord-014516-r59usk02 1004 24 referral referral NN cord-014516-r59usk02 1004 25 practice practice NN cord-014516-r59usk02 1004 26 . . . cord-014516-r59usk02 1005 1 Each each DT cord-014516-r59usk02 1005 2 dog dog NN cord-014516-r59usk02 1005 3 was be VBD cord-014516-r59usk02 1005 4 used use VBN cord-014516-r59usk02 1005 5 only only RB cord-014516-r59usk02 1005 6 once once RB cord-014516-r59usk02 1005 7 . . . cord-014516-r59usk02 1006 1 Owners owner NNS cord-014516-r59usk02 1006 2 were be VBD cord-014516-r59usk02 1006 3 asked ask VBN cord-014516-r59usk02 1006 4 to to TO cord-014516-r59usk02 1006 5 complete complete VB cord-014516-r59usk02 1006 6 a a DT cord-014516-r59usk02 1006 7 questionnaire questionnaire NN cord-014516-r59usk02 1006 8 that that WDT cord-014516-r59usk02 1006 9 assessed assess VBD cord-014516-r59usk02 1006 10 clinical clinical JJ cord-014516-r59usk02 1006 11 control control NN cord-014516-r59usk02 1006 12 . . . cord-014516-r59usk02 1007 1 The the DT cord-014516-r59usk02 1007 2 dogs dog NNS cord-014516-r59usk02 1007 3 were be VBD cord-014516-r59usk02 1007 4 then then RB cord-014516-r59usk02 1007 5 categorised categorise VBN cord-014516-r59usk02 1007 6 as as IN cord-014516-r59usk02 1007 7 being be VBG cord-014516-r59usk02 1007 8 over over RB cord-014516-r59usk02 1007 9 - - HYPH cord-014516-r59usk02 1007 10 controlled control VBN cord-014516-r59usk02 1007 11 , , , cord-014516-r59usk02 1007 12 well well RB cord-014516-r59usk02 1007 13 - - HYPH cord-014516-r59usk02 1007 14 controlled control VBN cord-014516-r59usk02 1007 15 , , , cord-014516-r59usk02 1007 16 moderately moderately RB cord-014516-r59usk02 1007 17 - - HYPH cord-014516-r59usk02 1007 18 controlled control VBN cord-014516-r59usk02 1007 19 and and CC cord-014516-r59usk02 1007 20 poorly poorly RB cord-014516-r59usk02 1007 21 - - HYPH cord-014516-r59usk02 1007 22 controlled control VBN cord-014516-r59usk02 1007 23 . . . cord-014516-r59usk02 1008 1 Cortisol cortisol NN cord-014516-r59usk02 1008 2 was be VBD cord-014516-r59usk02 1008 3 measured measure VBN cord-014516-r59usk02 1008 4 in in IN cord-014516-r59usk02 1008 5 serum serum NN cord-014516-r59usk02 1008 6 samples sample NNS cord-014516-r59usk02 1008 7 taken take VBN cord-014516-r59usk02 1008 8 pre pre JJ cord-014516-r59usk02 1008 9 - - JJ cord-014516-r59usk02 1008 10 trilostane trilostane JJ cord-014516-r59usk02 1008 11 ( ( -LRB- cord-014516-r59usk02 1008 12 peak peak NNP cord-014516-r59usk02 1008 13 ) ) -RRB- cord-014516-r59usk02 1008 14 , , , cord-014516-r59usk02 1008 15 3 3 CD cord-014516-r59usk02 1008 16 hours hour NNS cord-014516-r59usk02 1008 17 post post NN cord-014516-r59usk02 1008 18 - - JJ cord-014516-r59usk02 1008 19 trilostane trilostane JJ cord-014516-r59usk02 1008 20 ( ( -LRB- cord-014516-r59usk02 1008 21 trough trough NN cord-014516-r59usk02 1008 22 ) ) -RRB- cord-014516-r59usk02 1008 23 and and CC cord-014516-r59usk02 1008 24 1 1 CD cord-014516-r59usk02 1008 25 hour hour NN cord-014516-r59usk02 1008 26 post post JJ cord-014516-r59usk02 1008 27 - - JJ cord-014516-r59usk02 1008 28 ACTH acth JJ cord-014516-r59usk02 1008 29 injection injection NN cord-014516-r59usk02 1008 30 . . . cord-014516-r59usk02 1009 1 Dogs dog NNS cord-014516-r59usk02 1009 2 that that WDT cord-014516-r59usk02 1009 3 had have VBD cord-014516-r59usk02 1009 4 an an DT cord-014516-r59usk02 1009 5 increase increase NN cord-014516-r59usk02 1009 6 in in IN cord-014516-r59usk02 1009 7 cortisol cortisol NN cord-014516-r59usk02 1009 8 after after IN cord-014516-r59usk02 1009 9 trilostane trilostane NNP cord-014516-r59usk02 1009 10 administration administration NNP cord-014516-r59usk02 1009 11 were be VBD cord-014516-r59usk02 1009 12 excluded exclude VBN cord-014516-r59usk02 1009 13 . . . cord-014516-r59usk02 1010 1 A a DT cord-014516-r59usk02 1010 2 scoring scoring NN cord-014516-r59usk02 1010 3 system system NN cord-014516-r59usk02 1010 4 was be VBD cord-014516-r59usk02 1010 5 developed develop VBN cord-014516-r59usk02 1010 6 for for IN cord-014516-r59usk02 1010 7 each each DT cord-014516-r59usk02 1010 8 of of IN cord-014516-r59usk02 1010 9 these these DT cord-014516-r59usk02 1010 10 3 3 CD cord-014516-r59usk02 1010 11 measurements measurement NNS cord-014516-r59usk02 1010 12 . . . cord-014516-r59usk02 1011 1 A a DT cord-014516-r59usk02 1011 2 fourth fourth JJ cord-014516-r59usk02 1011 3 scoring scoring NN cord-014516-r59usk02 1011 4 system system NN cord-014516-r59usk02 1011 5 was be VBD cord-014516-r59usk02 1011 6 developed develop VBN cord-014516-r59usk02 1011 7 using use VBG cord-014516-r59usk02 1011 8 a a DT cord-014516-r59usk02 1011 9 novel novel JJ cord-014516-r59usk02 1011 10 algorithm algorithm NN cord-014516-r59usk02 1011 11 that that WDT cord-014516-r59usk02 1011 12 combined combine VBD cord-014516-r59usk02 1011 13 the the DT cord-014516-r59usk02 1011 14 peak peak NN cord-014516-r59usk02 1011 15 and and CC cord-014516-r59usk02 1011 16 trough trough NN cord-014516-r59usk02 1011 17 cortisol cortisol NN cord-014516-r59usk02 1011 18 ( ( -LRB- cord-014516-r59usk02 1011 19 peak peak NN cord-014516-r59usk02 1011 20 - - HYPH cord-014516-r59usk02 1011 21 trough trough NN cord-014516-r59usk02 1011 22 ) ) -RRB- cord-014516-r59usk02 1011 23 . . . cord-014516-r59usk02 1012 1 The the DT cord-014516-r59usk02 1012 2 results result NNS cord-014516-r59usk02 1012 3 of of IN cord-014516-r59usk02 1012 4 each each DT cord-014516-r59usk02 1012 5 of of IN cord-014516-r59usk02 1012 6 the the DT cord-014516-r59usk02 1012 7 4 4 CD cord-014516-r59usk02 1012 8 scoring scoring NN cord-014516-r59usk02 1012 9 systems system NNS cord-014516-r59usk02 1012 10 categorised categorise VBD cord-014516-r59usk02 1012 11 the the DT cord-014516-r59usk02 1012 12 dogs dog NNS cord-014516-r59usk02 1012 13 into into IN cord-014516-r59usk02 1012 14 those those DT cord-014516-r59usk02 1012 15 that that WDT cord-014516-r59usk02 1012 16 would would MD cord-014516-r59usk02 1012 17 be be VB cord-014516-r59usk02 1012 18 expected expect VBN cord-014516-r59usk02 1012 19 to to TO cord-014516-r59usk02 1012 20 be be VB cord-014516-r59usk02 1012 21 over over RB cord-014516-r59usk02 1012 22 - - HYPH cord-014516-r59usk02 1012 23 controlled control VBN cord-014516-r59usk02 1012 24 , , , cord-014516-r59usk02 1012 25 well well RB cord-014516-r59usk02 1012 26 - - HYPH cord-014516-r59usk02 1012 27 controlled control VBN cord-014516-r59usk02 1012 28 , , , cord-014516-r59usk02 1012 29 moderately moderately RB cord-014516-r59usk02 1012 30 - - HYPH cord-014516-r59usk02 1012 31 controlled control VBN cord-014516-r59usk02 1012 32 and and CC cord-014516-r59usk02 1012 33 poorly poorly RB cord-014516-r59usk02 1012 34 - - HYPH cord-014516-r59usk02 1012 35 controlled control VBN cord-014516-r59usk02 1012 36 . . . cord-014516-r59usk02 1013 1 Weighted weighted JJ cord-014516-r59usk02 1013 2 Kappa Kappa NNP cord-014516-r59usk02 1013 3 was be VBD cord-014516-r59usk02 1013 4 calculated calculate VBN cord-014516-r59usk02 1013 5 to to TO cord-014516-r59usk02 1013 6 assess assess VB cord-014516-r59usk02 1013 7 the the DT cord-014516-r59usk02 1013 8 agreement agreement NN cord-014516-r59usk02 1013 9 between between IN cord-014516-r59usk02 1013 10 the the DT cord-014516-r59usk02 1013 11 categorisation categorisation NN cord-014516-r59usk02 1013 12 according accord VBG cord-014516-r59usk02 1013 13 to to IN cord-014516-r59usk02 1013 14 each each DT cord-014516-r59usk02 1013 15 of of IN cord-014516-r59usk02 1013 16 the the DT cord-014516-r59usk02 1013 17 4 4 CD cord-014516-r59usk02 1013 18 methods method NNS cord-014516-r59usk02 1013 19 compared compare VBN cord-014516-r59usk02 1013 20 to to IN cord-014516-r59usk02 1013 21 the the DT cord-014516-r59usk02 1013 22 categorisation categorisation NN cord-014516-r59usk02 1013 23 using use VBG cord-014516-r59usk02 1013 24 the the DT cord-014516-r59usk02 1013 25 owners owner NNS cord-014516-r59usk02 1013 26 score score VBP cord-014516-r59usk02 1013 27 . . . cord-014516-r59usk02 1014 1 The the DT cord-014516-r59usk02 1014 2 Pearson Pearson NNP cord-014516-r59usk02 1014 3 correlation correlation NN cord-014516-r59usk02 1014 4 coefficient coefficient NN cord-014516-r59usk02 1014 5 was be VBD cord-014516-r59usk02 1014 6 calculated calculate VBN cord-014516-r59usk02 1014 7 to to TO cord-014516-r59usk02 1014 8 assess assess VB cord-014516-r59usk02 1014 9 relationships relationship NNS cord-014516-r59usk02 1014 10 between between IN cord-014516-r59usk02 1014 11 the the DT cord-014516-r59usk02 1014 12 various various JJ cord-014516-r59usk02 1014 13 parameters parameter NNS cord-014516-r59usk02 1014 14 . . . cord-014516-r59usk02 1015 1 In in IN cord-014516-r59usk02 1015 2 total total JJ cord-014516-r59usk02 1015 3 31 31 CD cord-014516-r59usk02 1015 4 tests test NNS cord-014516-r59usk02 1015 5 were be VBD cord-014516-r59usk02 1015 6 analysed analyse VBN cord-014516-r59usk02 1015 7 . . . cord-014516-r59usk02 1016 1 When when WRB cord-014516-r59usk02 1016 2 compared compare VBN cord-014516-r59usk02 1016 3 to to IN cord-014516-r59usk02 1016 4 the the DT cord-014516-r59usk02 1016 5 results result NNS cord-014516-r59usk02 1016 6 of of IN cord-014516-r59usk02 1016 7 the the DT cord-014516-r59usk02 1016 8 owner owner NN cord-014516-r59usk02 1016 9 's 's POS cord-014516-r59usk02 1016 10 questionnaire questionnaire NN cord-014516-r59usk02 1016 11 16 16 CD cord-014516-r59usk02 1016 12 , , , cord-014516-r59usk02 1016 13 13 13 CD cord-014516-r59usk02 1016 14 , , , cord-014516-r59usk02 1016 15 9 9 CD cord-014516-r59usk02 1016 16 and and CC cord-014516-r59usk02 1016 17 5 5 CD cord-014516-r59usk02 1016 18 dogs dog NNS cord-014516-r59usk02 1016 19 were be VBD cord-014516-r59usk02 1016 20 correctly correctly RB cord-014516-r59usk02 1016 21 categorised categorise VBN cord-014516-r59usk02 1016 22 using use VBG cord-014516-r59usk02 1016 23 the the DT cord-014516-r59usk02 1016 24 peak peak NN cord-014516-r59usk02 1016 25 - - HYPH cord-014516-r59usk02 1016 26 trough trough NN cord-014516-r59usk02 1016 27 , , , cord-014516-r59usk02 1016 28 peak peak NN cord-014516-r59usk02 1016 29 alone alone RB cord-014516-r59usk02 1016 30 , , , cord-014516-r59usk02 1016 31 post post JJ cord-014516-r59usk02 1016 32 - - JJ cord-014516-r59usk02 1016 33 ACTH ACTH NNP cord-014516-r59usk02 1016 34 and and CC cord-014516-r59usk02 1016 35 trough trough NN cord-014516-r59usk02 1016 36 alone alone RB cord-014516-r59usk02 1016 37 respectively respectively RB cord-014516-r59usk02 1016 38 . . . cord-014516-r59usk02 1017 1 Amongst amongst IN cord-014516-r59usk02 1017 2 the the DT cord-014516-r59usk02 1017 3 miscategorised miscategorise VBN cord-014516-r59usk02 1017 4 results result NNS cord-014516-r59usk02 1017 5 12 12 CD cord-014516-r59usk02 1017 6 , , , cord-014516-r59usk02 1017 7 17 17 CD cord-014516-r59usk02 1017 8 , , , cord-014516-r59usk02 1017 9 16 16 CD cord-014516-r59usk02 1017 10 and and CC cord-014516-r59usk02 1017 11 15 15 CD cord-014516-r59usk02 1017 12 dogs dog NNS cord-014516-r59usk02 1017 13 were be VBD cord-014516-r59usk02 1017 14 incorrect incorrect JJ cord-014516-r59usk02 1017 15 by by IN cord-014516-r59usk02 1017 16 1 1 CD cord-014516-r59usk02 1017 17 category category NN cord-014516-r59usk02 1017 18 and and CC cord-014516-r59usk02 1017 19 3 3 CD cord-014516-r59usk02 1017 20 , , , cord-014516-r59usk02 1017 21 1 1 CD cord-014516-r59usk02 1017 22 , , , cord-014516-r59usk02 1017 23 6 6 CD cord-014516-r59usk02 1017 24 and and CC cord-014516-r59usk02 1017 25 6 6 CD cord-014516-r59usk02 1017 26 dogs dog NNS cord-014516-r59usk02 1017 27 by by IN cord-014516-r59usk02 1017 28 2 2 CD cord-014516-r59usk02 1017 29 categories category NNS cord-014516-r59usk02 1017 30 using use VBG cord-014516-r59usk02 1017 31 the the DT cord-014516-r59usk02 1017 32 peak peak NN cord-014516-r59usk02 1017 33 - - HYPH cord-014516-r59usk02 1017 34 trough trough NN cord-014516-r59usk02 1017 35 , , , cord-014516-r59usk02 1017 36 peak peak NN cord-014516-r59usk02 1017 37 alone alone RB cord-014516-r59usk02 1017 38 , , , cord-014516-r59usk02 1017 39 post post JJ cord-014516-r59usk02 1017 40 - - JJ cord-014516-r59usk02 1017 41 ACTH ACTH NNP cord-014516-r59usk02 1017 42 and and CC cord-014516-r59usk02 1017 43 trough trough NN cord-014516-r59usk02 1017 44 alone alone RB cord-014516-r59usk02 1017 45 respectively respectively RB cord-014516-r59usk02 1017 46 . . . cord-014516-r59usk02 1018 1 All all DT cord-014516-r59usk02 1018 2 methods method NNS cord-014516-r59usk02 1018 3 correctly correctly RB cord-014516-r59usk02 1018 4 recognised recognise VBD cord-014516-r59usk02 1018 5 the the DT cord-014516-r59usk02 1018 6 over over RB cord-014516-r59usk02 1018 7 - - HYPH cord-014516-r59usk02 1018 8 controlled control VBN cord-014516-r59usk02 1018 9 dog dog NN cord-014516-r59usk02 1018 10 that that WDT cord-014516-r59usk02 1018 11 had have VBD cord-014516-r59usk02 1018 12 been be VBN cord-014516-r59usk02 1018 13 identified identify VBN cord-014516-r59usk02 1018 14 by by IN cord-014516-r59usk02 1018 15 the the DT cord-014516-r59usk02 1018 16 owner owner NN cord-014516-r59usk02 1018 17 's 's POS cord-014516-r59usk02 1018 18 score score NN cord-014516-r59usk02 1018 19 . . . cord-014516-r59usk02 1019 1 The the DT cord-014516-r59usk02 1019 2 weighted weighted JJ cord-014516-r59usk02 1019 3 kappas kappa NNS cord-014516-r59usk02 1019 4 for for IN cord-014516-r59usk02 1019 5 post post JJ cord-014516-r59usk02 1019 6 - - JJ cord-014516-r59usk02 1019 7 ACTH ACTH NNP cord-014516-r59usk02 1019 8 and and CC cord-014516-r59usk02 1019 9 trough trough NN cord-014516-r59usk02 1019 10 cortisol cortisol NN cord-014516-r59usk02 1019 11 categories category NNS cord-014516-r59usk02 1019 12 compared compare VBN cord-014516-r59usk02 1019 13 to to IN cord-014516-r59usk02 1019 14 the the DT cord-014516-r59usk02 1019 15 owner owner NN cord-014516-r59usk02 1019 16 score score NN cord-014516-r59usk02 1019 17 categories category NNS cord-014516-r59usk02 1019 18 were be VBD cord-014516-r59usk02 1019 19 0.09 0.09 CD cord-014516-r59usk02 1019 20 and and CC cord-014516-r59usk02 1019 21 0.11 0.11 CD cord-014516-r59usk02 1019 22 respectively respectively RB cord-014516-r59usk02 1019 23 ( ( -LRB- cord-014516-r59usk02 1019 24 defined define VBN cord-014516-r59usk02 1019 25 as as IN cord-014516-r59usk02 1019 26 slight slight JJ cord-014516-r59usk02 1019 27 agreement agreement NN cord-014516-r59usk02 1019 28 ) ) -RRB- cord-014516-r59usk02 1019 29 . . . cord-014516-r59usk02 1020 1 In in IN cord-014516-r59usk02 1020 2 contrast contrast NN cord-014516-r59usk02 1020 3 the the DT cord-014516-r59usk02 1020 4 weighted weighted JJ cord-014516-r59usk02 1020 5 kappas kappa NNS cord-014516-r59usk02 1020 6 for for IN cord-014516-r59usk02 1020 7 the the DT cord-014516-r59usk02 1020 8 peak peak NN cord-014516-r59usk02 1020 9 and and CC cord-014516-r59usk02 1020 10 peak peak NN cord-014516-r59usk02 1020 11 - - HYPH cord-014516-r59usk02 1020 12 trough trough NN cord-014516-r59usk02 1020 13 categories category NNS cord-014516-r59usk02 1020 14 were be VBD cord-014516-r59usk02 1020 15 0.36 0.36 CD cord-014516-r59usk02 1020 16 and and CC cord-014516-r59usk02 1020 17 0.34 0.34 CD cord-014516-r59usk02 1020 18 respectively respectively RB cord-014516-r59usk02 1020 19 ( ( -LRB- cord-014516-r59usk02 1020 20 defined define VBN cord-014516-r59usk02 1020 21 as as IN cord-014516-r59usk02 1020 22 fair fair JJ cord-014516-r59usk02 1020 23 agreement agreement NN cord-014516-r59usk02 1020 24 ) ) -RRB- cord-014516-r59usk02 1020 25 . . . cord-014516-r59usk02 1021 1 There there EX cord-014516-r59usk02 1021 2 were be VBD cord-014516-r59usk02 1021 3 no no DT cord-014516-r59usk02 1021 4 significant significant JJ cord-014516-r59usk02 1021 5 correlations correlation NNS cord-014516-r59usk02 1021 6 between between IN cord-014516-r59usk02 1021 7 the the DT cord-014516-r59usk02 1021 8 absolute absolute JJ cord-014516-r59usk02 1021 9 clinical clinical JJ cord-014516-r59usk02 1021 10 scores score NNS cord-014516-r59usk02 1021 11 and and CC cord-014516-r59usk02 1021 12 cortisol cortisol NN cord-014516-r59usk02 1021 13 concentrations concentration NNS cord-014516-r59usk02 1021 14 . . . cord-014516-r59usk02 1022 1 There there EX cord-014516-r59usk02 1022 2 were be VBD cord-014516-r59usk02 1022 3 significant significant JJ cord-014516-r59usk02 1022 4 correlations correlation NNS cord-014516-r59usk02 1022 5 between between IN cord-014516-r59usk02 1022 6 the the DT cord-014516-r59usk02 1022 7 3 3 CD cord-014516-r59usk02 1022 8 cortisol cortisol NN cord-014516-r59usk02 1022 9 measurements measurement NNS cord-014516-r59usk02 1022 10 . . . cord-014516-r59usk02 1023 1 The the DT cord-014516-r59usk02 1023 2 novel novel JJ cord-014516-r59usk02 1023 3 methods method NNS cord-014516-r59usk02 1023 4 of of IN cord-014516-r59usk02 1023 5 peak peak NN cord-014516-r59usk02 1023 6 - - HYPH cord-014516-r59usk02 1023 7 trough trough NN cord-014516-r59usk02 1023 8 and and CC cord-014516-r59usk02 1023 9 peak peak NN cord-014516-r59usk02 1023 10 cortisol cortisol NN cord-014516-r59usk02 1023 11 better well RBR cord-014516-r59usk02 1023 12 reflected reflect VBD cord-014516-r59usk02 1023 13 the the DT cord-014516-r59usk02 1023 14 level level NN cord-014516-r59usk02 1023 15 of of IN cord-014516-r59usk02 1023 16 clinical clinical JJ cord-014516-r59usk02 1023 17 control control NN cord-014516-r59usk02 1023 18 of of IN cord-014516-r59usk02 1023 19 hyperadrenocorticism hyperadrenocorticism NN cord-014516-r59usk02 1023 20 identified identify VBN cord-014516-r59usk02 1023 21 by by IN cord-014516-r59usk02 1023 22 the the DT cord-014516-r59usk02 1023 23 owners owner NNS cord-014516-r59usk02 1023 24 ' ' POS cord-014516-r59usk02 1023 25 questionnaire questionnaire NN cord-014516-r59usk02 1023 26 than than IN cord-014516-r59usk02 1023 27 either either DT cord-014516-r59usk02 1023 28 post post JJ cord-014516-r59usk02 1023 29 - - JJ cord-014516-r59usk02 1023 30 ACTH acth JJ cord-014516-r59usk02 1023 31 stimulation stimulation NN cord-014516-r59usk02 1023 32 or or CC cord-014516-r59usk02 1023 33 trough trough NN cord-014516-r59usk02 1023 34 cortisol cortisol NN cord-014516-r59usk02 1023 35 . . . cord-014516-r59usk02 1024 1 Peak peak NN cord-014516-r59usk02 1024 2 - - HYPH cord-014516-r59usk02 1024 3 trough trough NN cord-014516-r59usk02 1024 4 and and CC cord-014516-r59usk02 1024 5 peak peak NN cord-014516-r59usk02 1024 6 cortisol cortisol NN cord-014516-r59usk02 1024 7 concentrations concentration NNS cord-014516-r59usk02 1024 8 should should MD cord-014516-r59usk02 1024 9 be be VB cord-014516-r59usk02 1024 10 further further RB cord-014516-r59usk02 1024 11 investigated investigate VBN cord-014516-r59usk02 1024 12 as as IN cord-014516-r59usk02 1024 13 monitoring monitor VBG cord-014516-r59usk02 1024 14 methods method NNS cord-014516-r59usk02 1024 15 for for IN cord-014516-r59usk02 1024 16 trilostane trilostane NNP cord-014516-r59usk02 1024 17 . . . cord-014516-r59usk02 1025 1 Financial financial JJ cord-014516-r59usk02 1025 2 support support NN cord-014516-r59usk02 1025 3 from from IN cord-014516-r59usk02 1025 4 Dechra Dechra NNP cord-014516-r59usk02 1025 5 pharmaceuticals pharmaceutical NNS cord-014516-r59usk02 1025 6 . . . cord-014516-r59usk02 1026 1 The the DT cord-014516-r59usk02 1026 2 prognosis prognosis NN cord-014516-r59usk02 1026 3 of of IN cord-014516-r59usk02 1026 4 canine canine JJ cord-014516-r59usk02 1026 5 adrenocortical adrenocortical JJ cord-014516-r59usk02 1026 6 insufficiency insufficiency NN cord-014516-r59usk02 1026 7 is be VBZ cord-014516-r59usk02 1026 8 generally generally RB cord-014516-r59usk02 1026 9 regarded regard VBN cord-014516-r59usk02 1026 10 to to TO cord-014516-r59usk02 1026 11 be be VB cord-014516-r59usk02 1026 12 excellent excellent JJ cord-014516-r59usk02 1026 13 . . . cord-014516-r59usk02 1027 1 However however RB cord-014516-r59usk02 1027 2 , , , cord-014516-r59usk02 1027 3 there there EX cord-014516-r59usk02 1027 4 is be VBZ cord-014516-r59usk02 1027 5 paucity paucity NN cord-014516-r59usk02 1027 6 of of IN cord-014516-r59usk02 1027 7 sur sur JJ cord-014516-r59usk02 1027 8 - - HYPH cord-014516-r59usk02 1027 9 vival vival JJ cord-014516-r59usk02 1027 10 analyses analysis NNS cord-014516-r59usk02 1027 11 in in IN cord-014516-r59usk02 1027 12 the the DT cord-014516-r59usk02 1027 13 literature literature NN cord-014516-r59usk02 1027 14 . . . cord-014516-r59usk02 1028 1 The the DT cord-014516-r59usk02 1028 2 aim aim NN cord-014516-r59usk02 1028 3 of of IN cord-014516-r59usk02 1028 4 the the DT cord-014516-r59usk02 1028 5 present present JJ cord-014516-r59usk02 1028 6 study study NN cord-014516-r59usk02 1028 7 was be VBD cord-014516-r59usk02 1028 8 to to TO cord-014516-r59usk02 1028 9 evaluate evaluate VB cord-014516-r59usk02 1028 10 the the DT cord-014516-r59usk02 1028 11 survival survival NN cord-014516-r59usk02 1028 12 of of IN cord-014516-r59usk02 1028 13 dogs dog NNS cord-014516-r59usk02 1028 14 with with IN cord-014516-r59usk02 1028 15 the the DT cord-014516-r59usk02 1028 16 diagnosis diagnosis NN cord-014516-r59usk02 1028 17 adrenocortical adrenocortical JJ cord-014516-r59usk02 1028 18 insufficiency insufficiency NN cord-014516-r59usk02 1028 19 based base VBN cord-014516-r59usk02 1028 20 on on IN cord-014516-r59usk02 1028 21 data datum NNS cord-014516-r59usk02 1028 22 from from IN cord-014516-r59usk02 1028 23 a a DT cord-014516-r59usk02 1028 24 cohort cohort NN cord-014516-r59usk02 1028 25 of of IN cord-014516-r59usk02 1028 26 525 525 CD cord-014516-r59usk02 1029 1 , , , cord-014516-r59usk02 1029 2 028 028 CD cord-014516-r59usk02 1029 3 Swedish swedish JJ cord-014516-r59usk02 1029 4 client client NN cord-014516-r59usk02 1029 5 - - HYPH cord-014516-r59usk02 1029 6 owned own VBN cord-014516-r59usk02 1029 7 dogs dog NNS cord-014516-r59usk02 1029 8 insured insure VBN cord-014516-r59usk02 1029 9 in in IN cord-014516-r59usk02 1029 10 one one CD cord-014516-r59usk02 1029 11 insurance insurance NN cord-014516-r59usk02 1029 12 company company NN cord-014516-r59usk02 1029 13 ( ( -LRB- cord-014516-r59usk02 1029 14 Agria Agria NNP cord-014516-r59usk02 1029 15 Pet Pet NNP cord-014516-r59usk02 1029 16 Insurance Insurance NNP cord-014516-r59usk02 1029 17 , , , cord-014516-r59usk02 1029 18 Stockholm Stockholm NNP cord-014516-r59usk02 1029 19 , , , cord-014516-r59usk02 1029 20 Sweden Sweden NNP cord-014516-r59usk02 1029 21 ) ) -RRB- cord-014516-r59usk02 1029 22 during during IN cord-014516-r59usk02 1029 23 the the DT cord-014516-r59usk02 1029 24 time time NN cord-014516-r59usk02 1029 25 period period NN cord-014516-r59usk02 1029 26 1995 1995 CD cord-014516-r59usk02 1029 27 - - SYM cord-014516-r59usk02 1029 28 2006 2006 CD cord-014516-r59usk02 1029 29 . . . cord-014516-r59usk02 1030 1 Dogs dog NNS cord-014516-r59usk02 1030 2 were be VBD cord-014516-r59usk02 1030 3 identified identify VBN cord-014516-r59usk02 1030 4 by by IN cord-014516-r59usk02 1030 5 search search NN cord-014516-r59usk02 1030 6 for for IN cord-014516-r59usk02 1030 7 insurance insurance NN cord-014516-r59usk02 1030 8 claims claim NNS cord-014516-r59usk02 1030 9 with with IN cord-014516-r59usk02 1030 10 the the DT cord-014516-r59usk02 1030 11 register register JJ cord-014516-r59usk02 1030 12 code code NN cord-014516-r59usk02 1030 13 for for IN cord-014516-r59usk02 1030 14 adrenocortical adrenocortical JJ cord-014516-r59usk02 1030 15 insufficiency insufficiency NN cord-014516-r59usk02 1030 16 . . . cord-014516-r59usk02 1031 1 Dogs dog NNS cord-014516-r59usk02 1031 2 were be VBD cord-014516-r59usk02 1031 3 excluded exclude VBN cord-014516-r59usk02 1031 4 from from IN cord-014516-r59usk02 1031 5 analysis analysis NN cord-014516-r59usk02 1031 6 if if IN cord-014516-r59usk02 1031 7 they -PRON- PRP cord-014516-r59usk02 1031 8 had have VBD cord-014516-r59usk02 1031 9 a a DT cord-014516-r59usk02 1031 10 previous previous JJ cord-014516-r59usk02 1031 11 history history NN cord-014516-r59usk02 1031 12 of of IN cord-014516-r59usk02 1031 13 hypercortisolism hypercortisolism NN cord-014516-r59usk02 1031 14 , , , cord-014516-r59usk02 1031 15 and and CC cord-014516-r59usk02 1031 16 if if IN cord-014516-r59usk02 1031 17 they -PRON- PRP cord-014516-r59usk02 1031 18 were be VBD cord-014516-r59usk02 1031 19 born bear VBN cord-014516-r59usk02 1031 20 before before IN cord-014516-r59usk02 1031 21 begin begin NN cord-014516-r59usk02 1031 22 of of IN cord-014516-r59usk02 1031 23 the the DT cord-014516-r59usk02 1031 24 study study NN cord-014516-r59usk02 1031 25 period period NN cord-014516-r59usk02 1031 26 . . . cord-014516-r59usk02 1032 1 Kaplan Kaplan NNP cord-014516-r59usk02 1032 2 - - HYPH cord-014516-r59usk02 1032 3 Meier Meier NNP cord-014516-r59usk02 1032 4 survival survival NN cord-014516-r59usk02 1032 5 analysis analysis NN cord-014516-r59usk02 1032 6 was be VBD cord-014516-r59usk02 1032 7 performed perform VBN cord-014516-r59usk02 1032 8 . . . cord-014516-r59usk02 1033 1 Dogs dog NNS cord-014516-r59usk02 1033 2 were be VBD cord-014516-r59usk02 1033 3 regarded regard VBN cord-014516-r59usk02 1033 4 as as IN cord-014516-r59usk02 1033 5 censored censor VBN cord-014516-r59usk02 1033 6 when when WRB cord-014516-r59usk02 1033 7 the the DT cord-014516-r59usk02 1033 8 registered register VBN cord-014516-r59usk02 1033 9 cause cause NN cord-014516-r59usk02 1033 10 of of IN cord-014516-r59usk02 1033 11 death death NN cord-014516-r59usk02 1033 12 was be VBD cord-014516-r59usk02 1033 13 other other JJ cord-014516-r59usk02 1033 14 than than IN cord-014516-r59usk02 1033 15 adrenocortical adrenocortical JJ cord-014516-r59usk02 1033 16 insufficiency insufficiency NN cord-014516-r59usk02 1033 17 or or CC cord-014516-r59usk02 1033 18 hypercortisolism hypercortisolism NN cord-014516-r59usk02 1033 19 that that WDT cord-014516-r59usk02 1033 20 was be VBD cord-014516-r59usk02 1033 21 registered register VBN cord-014516-r59usk02 1033 22 after after IN cord-014516-r59usk02 1033 23 the the DT cord-014516-r59usk02 1033 24 first first JJ cord-014516-r59usk02 1033 25 claim claim NN cord-014516-r59usk02 1033 26 for for IN cord-014516-r59usk02 1033 27 adrenocortical adrenocortical JJ cord-014516-r59usk02 1033 28 insufficiency insufficiency NN cord-014516-r59usk02 1033 29 . . . cord-014516-r59usk02 1034 1 Data datum NNS cord-014516-r59usk02 1034 2 from from IN cord-014516-r59usk02 1034 3 297 297 CD cord-014516-r59usk02 1034 4 dogs dog NNS cord-014516-r59usk02 1034 5 was be VBD cord-014516-r59usk02 1034 6 included include VBN cord-014516-r59usk02 1034 7 . . . cord-014516-r59usk02 1035 1 One one CD cord-014516-r59usk02 1035 2 hundred hundred CD cord-014516-r59usk02 1035 3 twenty twenty CD cord-014516-r59usk02 1035 4 - - HYPH cord-014516-r59usk02 1035 5 four four CD cord-014516-r59usk02 1035 6 dogs dog NNS cord-014516-r59usk02 1035 7 were be VBD cord-014516-r59usk02 1035 8 registered register VBN cord-014516-r59usk02 1035 9 to to TO cord-014516-r59usk02 1035 10 be be VB cord-014516-r59usk02 1035 11 dead dead JJ cord-014516-r59usk02 1035 12 . . . cord-014516-r59usk02 1036 1 In in IN cord-014516-r59usk02 1036 2 81 81 CD cord-014516-r59usk02 1036 3 dogs dog NNS cord-014516-r59usk02 1036 4 the the DT cord-014516-r59usk02 1036 5 cause cause NN cord-014516-r59usk02 1036 6 of of IN cord-014516-r59usk02 1036 7 death death NN cord-014516-r59usk02 1036 8 was be VBD cord-014516-r59usk02 1036 9 related relate VBN cord-014516-r59usk02 1036 10 to to IN cord-014516-r59usk02 1036 11 the the DT cord-014516-r59usk02 1036 12 adrenocortical adrenocortical JJ cord-014516-r59usk02 1036 13 insufficiency insufficiency NN cord-014516-r59usk02 1036 14 . . . cord-014516-r59usk02 1037 1 The the DT cord-014516-r59usk02 1037 2 1-year 1-year CD cord-014516-r59usk02 1037 3 estimated estimate VBN cord-014516-r59usk02 1037 4 survival survival NN cord-014516-r59usk02 1037 5 - - HYPH cord-014516-r59usk02 1037 6 rate rate NN cord-014516-r59usk02 1037 7 was be VBD cord-014516-r59usk02 1037 8 81 81 CD cord-014516-r59usk02 1037 9 % % NN cord-014516-r59usk02 1037 10 ( ( -LRB- cord-014516-r59usk02 1037 11 95 95 CD cord-014516-r59usk02 1037 12 % % NN cord-014516-r59usk02 1037 13 CI CI NNP cord-014516-r59usk02 1037 14 , , , cord-014516-r59usk02 1037 15 76 76 CD cord-014516-r59usk02 1037 16 - - SYM cord-014516-r59usk02 1037 17 86 86 CD cord-014516-r59usk02 1037 18 % % NN cord-014516-r59usk02 1037 19 ) ) -RRB- cord-014516-r59usk02 1037 20 . . . cord-014516-r59usk02 1038 1 The the DT cord-014516-r59usk02 1038 2 3-year 3-year CD cord-014516-r59usk02 1038 3 estimated estimate VBN cord-014516-r59usk02 1038 4 survival survival NN cord-014516-r59usk02 1038 5 - - HYPH cord-014516-r59usk02 1038 6 rate rate NN cord-014516-r59usk02 1038 7 was be VBD cord-014516-r59usk02 1038 8 69 69 CD cord-014516-r59usk02 1038 9 % % NN cord-014516-r59usk02 1038 10 ( ( -LRB- cord-014516-r59usk02 1038 11 95 95 CD cord-014516-r59usk02 1038 12 % % NN cord-014516-r59usk02 1038 13 CI CI NNP cord-014516-r59usk02 1038 14 , , , cord-014516-r59usk02 1038 15 63 63 CD cord-014516-r59usk02 1038 16 - - SYM cord-014516-r59usk02 1038 17 76 76 CD cord-014516-r59usk02 1038 18 % % NN cord-014516-r59usk02 1038 19 ) ) -RRB- cord-014516-r59usk02 1038 20 . . . cord-014516-r59usk02 1039 1 The the DT cord-014516-r59usk02 1039 2 5-year 5-year CD cord-014516-r59usk02 1039 3 estimated estimate VBN cord-014516-r59usk02 1039 4 survival survival NN cord-014516-r59usk02 1039 5 - - HYPH cord-014516-r59usk02 1039 6 rate rate NN cord-014516-r59usk02 1039 7 was be VBD cord-014516-r59usk02 1039 8 59 59 CD cord-014516-r59usk02 1039 9 % % NN cord-014516-r59usk02 1039 10 ( ( -LRB- cord-014516-r59usk02 1039 11 95 95 CD cord-014516-r59usk02 1039 12 % % NN cord-014516-r59usk02 1039 13 CI CI NNP cord-014516-r59usk02 1039 14 , , , cord-014516-r59usk02 1039 15 51 51 CD cord-014516-r59usk02 1039 16 - - SYM cord-014516-r59usk02 1039 17 68 68 CD cord-014516-r59usk02 1039 18 % % NN cord-014516-r59usk02 1039 19 ) ) -RRB- cord-014516-r59usk02 1039 20 . . . cord-014516-r59usk02 1040 1 Twelve twelve CD cord-014516-r59usk02 1040 2 dogs dog NNS cord-014516-r59usk02 1040 3 ( ( -LRB- cord-014516-r59usk02 1040 4 4.0 4.0 CD cord-014516-r59usk02 1040 5 % % NN cord-014516-r59usk02 1040 6 ) ) -RRB- cord-014516-r59usk02 1040 7 were be VBD cord-014516-r59usk02 1040 8 still still RB cord-014516-r59usk02 1040 9 alive alive JJ cord-014516-r59usk02 1040 10 after after IN cord-014516-r59usk02 1040 11 7 7 CD cord-014516-r59usk02 1040 12 years year NNS cord-014516-r59usk02 1040 13 . . . cord-014516-r59usk02 1041 1 In in IN cord-014516-r59usk02 1041 2 conclusion conclusion NN cord-014516-r59usk02 1041 3 , , , cord-014516-r59usk02 1041 4 the the DT cord-014516-r59usk02 1041 5 long long JJ cord-014516-r59usk02 1041 6 - - HYPH cord-014516-r59usk02 1041 7 term term NN cord-014516-r59usk02 1041 8 survival survival NN cord-014516-r59usk02 1041 9 of of IN cord-014516-r59usk02 1041 10 dogs dog NNS cord-014516-r59usk02 1041 11 with with IN cord-014516-r59usk02 1041 12 adrenocortical adrenocortical JJ cord-014516-r59usk02 1041 13 insufficiency insufficiency NN cord-014516-r59usk02 1041 14 was be VBD cord-014516-r59usk02 1041 15 reasonably reasonably RB cord-014516-r59usk02 1041 16 good good JJ cord-014516-r59usk02 1041 17 . . . cord-014516-r59usk02 1042 1 However however RB cord-014516-r59usk02 1042 2 , , , cord-014516-r59usk02 1042 3 the the DT cord-014516-r59usk02 1042 4 diseases disease NNS cord-014516-r59usk02 1042 5 - - HYPH cord-014516-r59usk02 1042 6 related relate VBN cord-014516-r59usk02 1042 7 mortality mortality NN cord-014516-r59usk02 1042 8 was be VBD cord-014516-r59usk02 1042 9 higher high JJR cord-014516-r59usk02 1042 10 than than IN cord-014516-r59usk02 1042 11 expected expect VBN cord-014516-r59usk02 1042 12 , , , cord-014516-r59usk02 1042 13 and and CC cord-014516-r59usk02 1042 14 occurred occur VBD cord-014516-r59usk02 1042 15 mainly mainly RB cord-014516-r59usk02 1042 16 during during IN cord-014516-r59usk02 1042 17 the the DT cord-014516-r59usk02 1042 18 first first JJ cord-014516-r59usk02 1042 19 years year NNS cord-014516-r59usk02 1042 20 after after IN cord-014516-r59usk02 1042 21 diagnosis diagnosis NN cord-014516-r59usk02 1042 22 . . . cord-014516-r59usk02 1043 1 Conflicts conflict NNS cord-014516-r59usk02 1043 2 of of IN cord-014516-r59usk02 1043 3 interest interest NN cord-014516-r59usk02 1043 4 : : : cord-014516-r59usk02 1043 5 This this DT cord-014516-r59usk02 1043 6 study study NN cord-014516-r59usk02 1043 7 was be VBD cord-014516-r59usk02 1043 8 supported support VBN cord-014516-r59usk02 1043 9 by by IN cord-014516-r59usk02 1043 10 grants grant NNS cord-014516-r59usk02 1043 11 from from IN cord-014516-r59usk02 1043 12 the the DT cord-014516-r59usk02 1043 13 Swedish Swedish NNP cord-014516-r59usk02 1043 14 Research Research NNP cord-014516-r59usk02 1043 15 Council Council NNP cord-014516-r59usk02 1043 16 and and CC cord-014516-r59usk02 1043 17 the the DT cord-014516-r59usk02 1043 18 Foundation Foundation NNP cord-014516-r59usk02 1043 19 for for IN cord-014516-r59usk02 1043 20 Research Research NNP cord-014516-r59usk02 1043 21 , , , cord-014516-r59usk02 1043 22 Agria Agria NNP cord-014516-r59usk02 1043 23 Insurance Insurance NNP cord-014516-r59usk02 1043 24 Company Company NNP cord-014516-r59usk02 1043 25 . . . cord-014516-r59usk02 1044 1 The the DT cord-014516-r59usk02 1044 2 concomitant concomitant JJ cord-014516-r59usk02 1044 3 occurrence occurrence NN cord-014516-r59usk02 1044 4 of of IN cord-014516-r59usk02 1044 5 two two CD cord-014516-r59usk02 1044 6 or or CC cord-014516-r59usk02 1044 7 more more JJR cord-014516-r59usk02 1044 8 endocrine endocrine JJ cord-014516-r59usk02 1044 9 tumors tumor NNS cord-014516-r59usk02 1044 10 and/or and/or CC cord-014516-r59usk02 1044 11 hyperplasias hyperplasias NNP cord-014516-r59usk02 1044 12 , , , cord-014516-r59usk02 1044 13 known know VBN cord-014516-r59usk02 1044 14 as as IN cord-014516-r59usk02 1044 15 multiple multiple JJ cord-014516-r59usk02 1044 16 endocrine endocrine JJ cord-014516-r59usk02 1044 17 neoplasia neoplasia NN cord-014516-r59usk02 1044 18 ( ( -LRB- cord-014516-r59usk02 1044 19 MEN men NN cord-014516-r59usk02 1044 20 ) ) -RRB- cord-014516-r59usk02 1044 21 is be VBZ cord-014516-r59usk02 1044 22 a a DT cord-014516-r59usk02 1044 23 well well RB cord-014516-r59usk02 1044 24 - - HYPH cord-014516-r59usk02 1044 25 known know VBN cord-014516-r59usk02 1044 26 entity entity NN cord-014516-r59usk02 1044 27 in in IN cord-014516-r59usk02 1044 28 humans human NNS cord-014516-r59usk02 1044 29 . . . cord-014516-r59usk02 1045 1 Multiple multiple JJ cord-014516-r59usk02 1045 2 gene gene NN cord-014516-r59usk02 1045 3 mutations mutation NNS cord-014516-r59usk02 1045 4 have have VBP cord-014516-r59usk02 1045 5 been be VBN cord-014516-r59usk02 1045 6 identified identify VBN cord-014516-r59usk02 1045 7 . . . cord-014516-r59usk02 1046 1 The the DT cord-014516-r59usk02 1046 2 two two CD cord-014516-r59usk02 1046 3 major major JJ cord-014516-r59usk02 1046 4 forms form NNS cord-014516-r59usk02 1046 5 are be VBP cord-014516-r59usk02 1046 6 MEN1 MEN1 NNP cord-014516-r59usk02 1046 7 and and CC cord-014516-r59usk02 1046 8 MEN2 MEN2 NNP cord-014516-r59usk02 1046 9 . . . cord-014516-r59usk02 1047 1 In in IN cord-014516-r59usk02 1047 2 MEN1 MEN1 NNP cord-014516-r59usk02 1047 3 , , , cord-014516-r59usk02 1047 4 the the DT cord-014516-r59usk02 1047 5 main main JJ cord-014516-r59usk02 1047 6 affected affected JJ cord-014516-r59usk02 1047 7 organs organ NNS cord-014516-r59usk02 1047 8 are be VBP cord-014516-r59usk02 1047 9 parathyroid parathyroid JJ cord-014516-r59usk02 1047 10 , , , cord-014516-r59usk02 1047 11 pancreas pancreas NN cord-014516-r59usk02 1047 12 and and CC cord-014516-r59usk02 1047 13 pituitary pituitary JJ cord-014516-r59usk02 1047 14 gland gland NN cord-014516-r59usk02 1047 15 . . . cord-014516-r59usk02 1048 1 MEN2 MEN2 NNP cord-014516-r59usk02 1048 2 occurs occur VBZ cord-014516-r59usk02 1048 3 in in IN cord-014516-r59usk02 1048 4 3 3 CD cord-014516-r59usk02 1048 5 clinical clinical JJ cord-014516-r59usk02 1048 6 variants variant NNS cord-014516-r59usk02 1048 7 : : : cord-014516-r59usk02 1048 8 MEN2A men2a ADD cord-014516-r59usk02 1048 9 , , , cord-014516-r59usk02 1048 10 characterized characterize VBN cord-014516-r59usk02 1048 11 by by IN cord-014516-r59usk02 1048 12 medullary medullary JJ cord-014516-r59usk02 1048 13 thyroid thyroid NN cord-014516-r59usk02 1048 14 carcinoma carcinoma NN cord-014516-r59usk02 1048 15 ( ( -LRB- cord-014516-r59usk02 1048 16 MTC MTC NNP cord-014516-r59usk02 1048 17 ) ) -RRB- cord-014516-r59usk02 1048 18 , , , cord-014516-r59usk02 1048 19 pheochromocytoma pheochromocytoma NN cord-014516-r59usk02 1048 20 and and CC cord-014516-r59usk02 1048 21 primary primary JJ cord-014516-r59usk02 1048 22 hyperparathyroidism hyperparathyroidism NN cord-014516-r59usk02 1048 23 ; ; : cord-014516-r59usk02 1048 24 MEN man NNS cord-014516-r59usk02 1048 25 2B 2b CD cord-014516-r59usk02 1048 26 , , , cord-014516-r59usk02 1048 27 characterized characterize VBN cord-014516-r59usk02 1048 28 by by IN cord-014516-r59usk02 1048 29 MTC MTC NNP cord-014516-r59usk02 1048 30 , , , cord-014516-r59usk02 1048 31 pheochromocytoma pheochromocytoma NN cord-014516-r59usk02 1048 32 and and CC cord-014516-r59usk02 1048 33 additionally additionally RB cord-014516-r59usk02 1048 34 abnormalities abnormality NNS cord-014516-r59usk02 1048 35 ; ; : cord-014516-r59usk02 1048 36 familial familial JJ cord-014516-r59usk02 1048 37 medullary medullary JJ cord-014516-r59usk02 1048 38 thyroid thyroid NN cord-014516-r59usk02 1048 39 carcinoma carcinoma NN cord-014516-r59usk02 1048 40 . . . cord-014516-r59usk02 1049 1 In in IN cord-014516-r59usk02 1049 2 dogs dog NNS cord-014516-r59usk02 1049 3 and and CC cord-014516-r59usk02 1049 4 cats cat NNS cord-014516-r59usk02 1049 5 only only RB cord-014516-r59usk02 1049 6 a a DT cord-014516-r59usk02 1049 7 few few JJ cord-014516-r59usk02 1049 8 cases case NNS cord-014516-r59usk02 1049 9 have have VBP cord-014516-r59usk02 1049 10 been be VBN cord-014516-r59usk02 1049 11 reported report VBN cord-014516-r59usk02 1049 12 and and CC cord-014516-r59usk02 1049 13 it -PRON- PRP cord-014516-r59usk02 1049 14 is be VBZ cord-014516-r59usk02 1049 15 unknown unknown JJ cord-014516-r59usk02 1049 16 whether whether IN cord-014516-r59usk02 1049 17 hereditary hereditary JJ cord-014516-r59usk02 1049 18 MEN men NN cord-014516-r59usk02 1049 19 - - HYPH cord-014516-r59usk02 1049 20 like like JJ cord-014516-r59usk02 1049 21 syndromes syndrome NNS cord-014516-r59usk02 1049 22 exist exist VBP cord-014516-r59usk02 1049 23 in in IN cord-014516-r59usk02 1049 24 these these DT cord-014516-r59usk02 1049 25 species specie NNS cord-014516-r59usk02 1049 26 . . . cord-014516-r59usk02 1050 1 The the DT cord-014516-r59usk02 1050 2 aim aim NN cord-014516-r59usk02 1050 3 of of IN cord-014516-r59usk02 1050 4 this this DT cord-014516-r59usk02 1050 5 study study NN cord-014516-r59usk02 1050 6 was be VBD cord-014516-r59usk02 1050 7 to to TO cord-014516-r59usk02 1050 8 evaluate evaluate VB cord-014516-r59usk02 1050 9 the the DT cord-014516-r59usk02 1050 10 prevalence prevalence NN cord-014516-r59usk02 1050 11 of of IN cord-014516-r59usk02 1050 12 multiple multiple JJ cord-014516-r59usk02 1050 13 endocrine endocrine JJ cord-014516-r59usk02 1050 14 tumors tumor NNS cord-014516-r59usk02 1050 15 in in IN cord-014516-r59usk02 1050 16 dogs dog NNS cord-014516-r59usk02 1050 17 and and CC cord-014516-r59usk02 1050 18 cats cat NNS cord-014516-r59usk02 1050 19 at at IN cord-014516-r59usk02 1050 20 our -PRON- PRP$ cord-014516-r59usk02 1050 21 institution institution NN cord-014516-r59usk02 1050 22 , , , cord-014516-r59usk02 1050 23 to to TO cord-014516-r59usk02 1050 24 identify identify VB cord-014516-r59usk02 1050 25 possible possible JJ cord-014516-r59usk02 1050 26 breed breed NN cord-014516-r59usk02 1050 27 and and CC cord-014516-r59usk02 1050 28 sex sex NN cord-014516-r59usk02 1050 29 predispositions predisposition NNS cord-014516-r59usk02 1050 30 and and CC cord-014516-r59usk02 1050 31 to to TO cord-014516-r59usk02 1050 32 investigate investigate VB cord-014516-r59usk02 1050 33 similarities similarity NNS cord-014516-r59usk02 1050 34 with with IN cord-014516-r59usk02 1050 35 the the DT cord-014516-r59usk02 1050 36 human human JJ cord-014516-r59usk02 1050 37 MEN man NNS cord-014516-r59usk02 1050 38 syndromes syndrome NNS cord-014516-r59usk02 1050 39 . . . cord-014516-r59usk02 1051 1 Autopsy autopsy JJ cord-014516-r59usk02 1051 2 reports report NNS cord-014516-r59usk02 1051 3 of of IN cord-014516-r59usk02 1051 4 dogs dog NNS cord-014516-r59usk02 1051 5 and and CC cord-014516-r59usk02 1051 6 cats cat NNS cord-014516-r59usk02 1051 7 from from IN cord-014516-r59usk02 1051 8 2004 2004 CD cord-014516-r59usk02 1051 9 until until IN cord-014516-r59usk02 1051 10 2014 2014 CD cord-014516-r59usk02 1051 11 were be VBD cord-014516-r59usk02 1051 12 reviewed review VBN cord-014516-r59usk02 1051 13 . . . cord-014516-r59usk02 1052 1 Animals animal NNS cord-014516-r59usk02 1052 2 with with IN cord-014516-r59usk02 1052 3 at at RB cord-014516-r59usk02 1052 4 least least RBS cord-014516-r59usk02 1052 5 two two CD cord-014516-r59usk02 1052 6 endocrine endocrine JJ cord-014516-r59usk02 1052 7 tumors tumor NNS cord-014516-r59usk02 1052 8 / / SYM cord-014516-r59usk02 1052 9 hyperplasias hyperplasias FW cord-014516-r59usk02 1052 10 ( ( -LRB- cord-014516-r59usk02 1052 11 ETH ETH NNP cord-014516-r59usk02 1052 12 ) ) -RRB- cord-014516-r59usk02 1052 13 were be VBD cord-014516-r59usk02 1052 14 included include VBN cord-014516-r59usk02 1052 15 . . . cord-014516-r59usk02 1053 1 Autopsy autopsy JJ cord-014516-r59usk02 1053 2 reports report NNS cord-014516-r59usk02 1053 3 of of IN cord-014516-r59usk02 1053 4 951 951 CD cord-014516-r59usk02 1053 5 dogs dog NNS cord-014516-r59usk02 1053 6 and and CC cord-014516-r59usk02 1053 7 1155 1155 CD cord-014516-r59usk02 1053 8 cats cat NNS cord-014516-r59usk02 1053 9 were be VBD cord-014516-r59usk02 1053 10 examined examine VBN cord-014516-r59usk02 1053 11 . . . cord-014516-r59usk02 1054 1 149 149 CD cord-014516-r59usk02 1054 2 dogs dog NNS cord-014516-r59usk02 1054 3 had have VBD cord-014516-r59usk02 1054 4 ETH eth NN cord-014516-r59usk02 1054 5 affecting affect VBG cord-014516-r59usk02 1054 6 a a DT cord-014516-r59usk02 1054 7 single single JJ cord-014516-r59usk02 1054 8 organ organ NN cord-014516-r59usk02 1054 9 , , , cord-014516-r59usk02 1054 10 24 24 CD cord-014516-r59usk02 1054 11 had have VBD cord-014516-r59usk02 1054 12 multiple multiple JJ cord-014516-r59usk02 1054 13 ETH eth NN cord-014516-r59usk02 1054 14 ; ; : cord-014516-r59usk02 1054 15 123 123 CD cord-014516-r59usk02 1054 16 cats cat NNS cord-014516-r59usk02 1054 17 had have VBD cord-014516-r59usk02 1054 18 single single JJ cord-014516-r59usk02 1054 19 ETH ETH NNP cord-014516-r59usk02 1054 20 , , , cord-014516-r59usk02 1054 21 21 21 CD cord-014516-r59usk02 1054 22 had have VBD cord-014516-r59usk02 1054 23 multiple multiple JJ cord-014516-r59usk02 1054 24 ETH eth NN cord-014516-r59usk02 1054 25 . . . cord-014516-r59usk02 1055 1 In in IN cord-014516-r59usk02 1055 2 dogs dog NNS cord-014516-r59usk02 1055 3 with with IN cord-014516-r59usk02 1055 4 multiple multiple JJ cord-014516-r59usk02 1055 5 ETH eth NN cord-014516-r59usk02 1055 6 , , , cord-014516-r59usk02 1055 7 the the DT cord-014516-r59usk02 1055 8 most most RBS cord-014516-r59usk02 1055 9 common common JJ cord-014516-r59usk02 1055 10 breeds breed NNS cord-014516-r59usk02 1055 11 were be VBD cord-014516-r59usk02 1055 12 West West NNP cord-014516-r59usk02 1055 13 Highland Highland NNP cord-014516-r59usk02 1055 14 White White NNP cord-014516-r59usk02 1055 15 Terrier Terrier NNP cord-014516-r59usk02 1055 16 ( ( -LRB- cord-014516-r59usk02 1055 17 WHWT WHWT NNP cord-014516-r59usk02 1055 18 , , , cord-014516-r59usk02 1055 19 3/24 3/24 CD cord-014516-r59usk02 1055 20 ) ) -RRB- cord-014516-r59usk02 1055 21 , , , cord-014516-r59usk02 1055 22 Poodle Poodle NNP cord-014516-r59usk02 1055 23 , , , cord-014516-r59usk02 1055 24 Golden Golden NNP cord-014516-r59usk02 1055 25 Retriever Retriever NNP cord-014516-r59usk02 1055 26 , , , cord-014516-r59usk02 1055 27 mixed mixed JJ cord-014516-r59usk02 1055 28 - - HYPH cord-014516-r59usk02 1055 29 breed breed NN cord-014516-r59usk02 1055 30 dogs dog NNS cord-014516-r59usk02 1055 31 ( ( -LRB- cord-014516-r59usk02 1055 32 each each DT cord-014516-r59usk02 1055 33 2/24 2/24 CD cord-014516-r59usk02 1055 34 ) ) -RRB- cord-014516-r59usk02 1055 35 . . . cord-014516-r59usk02 1056 1 14/24 14/24 CD cord-014516-r59usk02 1056 2 were be VBD cord-014516-r59usk02 1056 3 male male JJ cord-014516-r59usk02 1056 4 ( ( -LRB- cord-014516-r59usk02 1056 5 13 13 CD cord-014516-r59usk02 1056 6 intact intact JJ cord-014516-r59usk02 1056 7 ) ) -RRB- cord-014516-r59usk02 1056 8 ; ; : cord-014516-r59usk02 1056 9 10/24 10/24 CD cord-014516-r59usk02 1056 10 were be VBD cord-014516-r59usk02 1056 11 female female JJ cord-014516-r59usk02 1056 12 ( ( -LRB- cord-014516-r59usk02 1056 13 10 10 CD cord-014516-r59usk02 1056 14 neutered neutered JJ cord-014516-r59usk02 1056 15 ) ) -RRB- cord-014516-r59usk02 1056 16 . . . cord-014516-r59usk02 1057 1 Median median JJ cord-014516-r59usk02 1057 2 age age NN cord-014516-r59usk02 1057 3 was be VBD cord-014516-r59usk02 1057 4 12 12 CD cord-014516-r59usk02 1057 5 years year NNS cord-014516-r59usk02 1057 6 ( ( -LRB- cord-014516-r59usk02 1057 7 range range VBP cord-014516-r59usk02 1057 8 7 7 CD cord-014516-r59usk02 1057 9 - - SYM cord-014516-r59usk02 1057 10 18 18 CD cord-014516-r59usk02 1057 11 ) ) -RRB- cord-014516-r59usk02 1057 12 . . . cord-014516-r59usk02 1058 1 The the DT cord-014516-r59usk02 1058 2 most most RBS cord-014516-r59usk02 1058 3 common common JJ cord-014516-r59usk02 1058 4 combination combination NN cord-014516-r59usk02 1058 5 was be VBD cord-014516-r59usk02 1058 6 multiple multiple JJ cord-014516-r59usk02 1058 7 testicle testicle NN cord-014516-r59usk02 1058 8 tumors tumor NNS cord-014516-r59usk02 1058 9 of of IN cord-014516-r59usk02 1058 10 various various JJ cord-014516-r59usk02 1058 11 types type NNS cord-014516-r59usk02 1058 12 ( ( -LRB- cord-014516-r59usk02 1058 13 4/24 4/24 CD cord-014516-r59usk02 1058 14 ) ) -RRB- cord-014516-r59usk02 1058 15 . . . cord-014516-r59usk02 1059 1 The the DT cord-014516-r59usk02 1059 2 most most RBS cord-014516-r59usk02 1059 3 common common JJ cord-014516-r59usk02 1059 4 affected affect VBN cord-014516-r59usk02 1059 5 organs organ NNS cord-014516-r59usk02 1059 6 were be VBD cord-014516-r59usk02 1059 7 the the DT cord-014516-r59usk02 1059 8 adrenals adrenal NNS cord-014516-r59usk02 1059 9 ( ( -LRB- cord-014516-r59usk02 1059 10 18/24 18/24 CD cord-014516-r59usk02 1059 11 ) ) -RRB- cord-014516-r59usk02 1059 12 . . . cord-014516-r59usk02 1060 1 Adrenal adrenal JJ cord-014516-r59usk02 1060 2 cortical cortical JJ cord-014516-r59usk02 1060 3 adenomas adenoma NNS cord-014516-r59usk02 1060 4 / / SYM cord-014516-r59usk02 1060 5 carcinomas carcinoma NNS cord-014516-r59usk02 1060 6 / / SYM cord-014516-r59usk02 1060 7 hyperplasias hyperplasias NNPS cord-014516-r59usk02 1060 8 were be VBD cord-014516-r59usk02 1060 9 mainly mainly RB cord-014516-r59usk02 1060 10 associated associate VBN cord-014516-r59usk02 1060 11 with with IN cord-014516-r59usk02 1060 12 pheochromocytomas pheochromocytomas NNP cord-014516-r59usk02 1060 13 ( ( -LRB- cord-014516-r59usk02 1060 14 3/ 3/ CD cord-014516-r59usk02 1060 15 24 24 CD cord-014516-r59usk02 1060 16 ) ) -RRB- cord-014516-r59usk02 1060 17 , , , cord-014516-r59usk02 1060 18 testicle testicle NN cord-014516-r59usk02 1060 19 tumors tumor NNS cord-014516-r59usk02 1060 20 ( ( -LRB- cord-014516-r59usk02 1060 21 3/24 3/24 CD cord-014516-r59usk02 1060 22 ) ) -RRB- cord-014516-r59usk02 1060 23 and and CC cord-014516-r59usk02 1060 24 insulinomas insulinomas NNP cord-014516-r59usk02 1060 25 ( ( -LRB- cord-014516-r59usk02 1060 26 2/24 2/24 CD cord-014516-r59usk02 1060 27 ) ) -RRB- cord-014516-r59usk02 1060 28 . . . cord-014516-r59usk02 1061 1 All all DT cord-014516-r59usk02 1061 2 3 3 CD cord-014516-r59usk02 1061 3 WHWTs WHWTs NNPS cord-014516-r59usk02 1061 4 had have VBD cord-014516-r59usk02 1061 5 adrenal adrenal JJ cord-014516-r59usk02 1061 6 adenomas adenoma NNS cord-014516-r59usk02 1061 7 . . . cord-014516-r59usk02 1062 1 Both both DT cord-014516-r59usk02 1062 2 Poodles poodle NNS cord-014516-r59usk02 1062 3 had have VBD cord-014516-r59usk02 1062 4 pheochromocytoma pheochromocytoma NN cord-014516-r59usk02 1062 5 associated associate VBN cord-014516-r59usk02 1062 6 with with IN cord-014516-r59usk02 1062 7 pituitary pituitary JJ cord-014516-r59usk02 1062 8 adenoma adenoma NN cord-014516-r59usk02 1062 9 or or CC cord-014516-r59usk02 1062 10 adrenal adrenal JJ cord-014516-r59usk02 1062 11 hyperplasia hyperplasia NN cord-014516-r59usk02 1062 12 . . . cord-014516-r59usk02 1063 1 2 2 CD cord-014516-r59usk02 1063 2 dogs dog NNS cord-014516-r59usk02 1063 3 showed show VBD cord-014516-r59usk02 1063 4 tumor tumor NN cord-014516-r59usk02 1063 5 combinations combination NNS cord-014516-r59usk02 1063 6 similar similar JJ cord-014516-r59usk02 1063 7 to to IN cord-014516-r59usk02 1063 8 the the DT cord-014516-r59usk02 1063 9 human human JJ cord-014516-r59usk02 1063 10 MEN1 MEN1 NNP cord-014516-r59usk02 1063 11 syndrome syndrome NN cord-014516-r59usk02 1063 12 : : : cord-014516-r59usk02 1063 13 pituitary pituitary JJ cord-014516-r59usk02 1063 14 adenoma adenoma NN cord-014516-r59usk02 1063 15 and and CC cord-014516-r59usk02 1063 16 insulinoma insulinoma NN cord-014516-r59usk02 1063 17 ; ; , cord-014516-r59usk02 1063 18 pituitary pituitary JJ cord-014516-r59usk02 1063 19 adenoma adenoma NN cord-014516-r59usk02 1063 20 and and CC cord-014516-r59usk02 1063 21 parathyroid parathyroid JJ cord-014516-r59usk02 1063 22 hyperplasia hyperplasia NN cord-014516-r59usk02 1063 23 . . . cord-014516-r59usk02 1064 1 19/21 19/21 CD cord-014516-r59usk02 1064 2 cats cat NNS cord-014516-r59usk02 1064 3 were be VBD cord-014516-r59usk02 1064 4 domestic domestic JJ cord-014516-r59usk02 1064 5 short short JJ cord-014516-r59usk02 1064 6 / / SYM cord-014516-r59usk02 1064 7 long long JJ cord-014516-r59usk02 1064 8 hair hair NN cord-014516-r59usk02 1064 9 , , , cord-014516-r59usk02 1064 10 2/21 2/21 CD cord-014516-r59usk02 1064 11 were be VBD cord-014516-r59usk02 1064 12 Persians Persians NNPS cord-014516-r59usk02 1064 13 . . . cord-014516-r59usk02 1065 1 11/21 11/21 CD cord-014516-r59usk02 1065 2 were be VBD cord-014516-r59usk02 1065 3 male male JJ cord-014516-r59usk02 1065 4 ( ( -LRB- cord-014516-r59usk02 1065 5 7 7 CD cord-014516-r59usk02 1065 6 castrated castrated JJ cord-014516-r59usk02 1065 7 ) ) -RRB- cord-014516-r59usk02 1065 8 ; ; : cord-014516-r59usk02 1065 9 10/21 10/21 CD cord-014516-r59usk02 1065 10 were be VBD cord-014516-r59usk02 1065 11 female female JJ cord-014516-r59usk02 1065 12 ( ( -LRB- cord-014516-r59usk02 1065 13 9 9 CD cord-014516-r59usk02 1065 14 neutered neutered JJ cord-014516-r59usk02 1065 15 ) ) -RRB- cord-014516-r59usk02 1065 16 . . . cord-014516-r59usk02 1066 1 The the DT cord-014516-r59usk02 1066 2 median median JJ cord-014516-r59usk02 1066 3 age age NN cord-014516-r59usk02 1066 4 was be VBD cord-014516-r59usk02 1066 5 15.5 15.5 CD cord-014516-r59usk02 1066 6 years year NNS cord-014516-r59usk02 1067 1 ( ( -LRB- cord-014516-r59usk02 1067 2 range range NNP cord-014516-r59usk02 1067 3 10 10 CD cord-014516-r59usk02 1067 4 - - SYM cord-014516-r59usk02 1067 5 19 19 CD cord-014516-r59usk02 1067 6 ) ) -RRB- cord-014516-r59usk02 1067 7 . . . cord-014516-r59usk02 1068 1 The the DT cord-014516-r59usk02 1068 2 most most RBS cord-014516-r59usk02 1068 3 common common JJ cord-014516-r59usk02 1068 4 affected affect VBN cord-014516-r59usk02 1068 5 organs organ NNS cord-014516-r59usk02 1068 6 were be VBD cord-014516-r59usk02 1068 7 thyroid thyroid JJ cord-014516-r59usk02 1068 8 glands gland NNS cord-014516-r59usk02 1068 9 ( ( -LRB- cord-014516-r59usk02 1068 10 18/21 18/21 CD cord-014516-r59usk02 1068 11 ) ) -RRB- cord-014516-r59usk02 1068 12 , , , cord-014516-r59usk02 1068 13 combined combine VBN cord-014516-r59usk02 1068 14 mostly mostly RB cord-014516-r59usk02 1068 15 with with IN cord-014516-r59usk02 1068 16 lesions lesion NNS cord-014516-r59usk02 1068 17 of of IN cord-014516-r59usk02 1068 18 parathyroid parathyroid NN cord-014516-r59usk02 1068 19 ( ( -LRB- cord-014516-r59usk02 1068 20 10/21 10/21 CD cord-014516-r59usk02 1068 21 ) ) -RRB- cord-014516-r59usk02 1068 22 and and CC cord-014516-r59usk02 1068 23 adrenal adrenal JJ cord-014516-r59usk02 1068 24 glands gland NNS cord-014516-r59usk02 1068 25 ( ( -LRB- cord-014516-r59usk02 1068 26 7/21 7/21 CD cord-014516-r59usk02 1068 27 ) ) -RRB- cord-014516-r59usk02 1068 28 . . . cord-014516-r59usk02 1069 1 None none NN cord-014516-r59usk02 1069 2 of of IN cord-014516-r59usk02 1069 3 the the DT cord-014516-r59usk02 1069 4 cats cat NNS cord-014516-r59usk02 1069 5 had have VBD cord-014516-r59usk02 1069 6 combinations combination NNS cord-014516-r59usk02 1069 7 similar similar JJ cord-014516-r59usk02 1069 8 to to IN cord-014516-r59usk02 1069 9 the the DT cord-014516-r59usk02 1069 10 human human JJ cord-014516-r59usk02 1069 11 MEN man NNS cord-014516-r59usk02 1069 12 syndromes syndrome NNS cord-014516-r59usk02 1069 13 . . . cord-014516-r59usk02 1070 1 The the DT cord-014516-r59usk02 1070 2 prevalence prevalence NN cord-014516-r59usk02 1070 3 of of IN cord-014516-r59usk02 1070 4 multiple multiple JJ cord-014516-r59usk02 1070 5 ETH eth NN cord-014516-r59usk02 1070 6 in in IN cord-014516-r59usk02 1070 7 dogs dog NNS cord-014516-r59usk02 1070 8 and and CC cord-014516-r59usk02 1070 9 cats cat NNS cord-014516-r59usk02 1070 10 was be VBD cord-014516-r59usk02 1070 11 2.5 2.5 CD cord-014516-r59usk02 1070 12 % % NN cord-014516-r59usk02 1070 13 and and CC cord-014516-r59usk02 1070 14 1.8 1.8 CD cord-014516-r59usk02 1070 15 % % NN cord-014516-r59usk02 1070 16 . . . cord-014516-r59usk02 1071 1 MEN men NN cord-014516-r59usk02 1071 2 - - HYPH cord-014516-r59usk02 1071 3 like like JJ cord-014516-r59usk02 1071 4 syndromes syndrome NNS cord-014516-r59usk02 1071 5 were be VBD cord-014516-r59usk02 1071 6 extremely extremely RB cord-014516-r59usk02 1071 7 rare rare JJ cord-014516-r59usk02 1071 8 in in IN cord-014516-r59usk02 1071 9 dogs dog NNS cord-014516-r59usk02 1071 10 and and CC cord-014516-r59usk02 1071 11 non non JJ cord-014516-r59usk02 1071 12 - - JJ cord-014516-r59usk02 1071 13 existing existing JJ cord-014516-r59usk02 1071 14 in in IN cord-014516-r59usk02 1071 15 cats cat NNS cord-014516-r59usk02 1071 16 . . . cord-014516-r59usk02 1072 1 No no DT cord-014516-r59usk02 1072 2 sex sex NN cord-014516-r59usk02 1072 3 predisposition predisposition NN cord-014516-r59usk02 1072 4 was be VBD cord-014516-r59usk02 1072 5 observed observe VBN cord-014516-r59usk02 1072 6 . . . cord-014516-r59usk02 1073 1 Possible possible JJ cord-014516-r59usk02 1073 2 breed breed NN cord-014516-r59usk02 1073 3 predispositions predisposition NNS cord-014516-r59usk02 1073 4 need need VBP cord-014516-r59usk02 1073 5 further further JJ cord-014516-r59usk02 1073 6 investigations investigation NNS cord-014516-r59usk02 1073 7 . . . cord-014516-r59usk02 1074 1 No no DT cord-014516-r59usk02 1074 2 conflicts conflict NNS cord-014516-r59usk02 1074 3 of of IN cord-014516-r59usk02 1074 4 interest interest NN cord-014516-r59usk02 1074 5 reported report VBN cord-014516-r59usk02 1074 6 . . . cord-014516-r59usk02 1075 1 Canine canine JJ cord-014516-r59usk02 1075 2 angiostrongylosis angiostrongylosis NN cord-014516-r59usk02 1075 3 is be VBZ cord-014516-r59usk02 1075 4 an an DT cord-014516-r59usk02 1075 5 increasingly increasingly RB cord-014516-r59usk02 1075 6 reported report VBN cord-014516-r59usk02 1075 7 disease disease NN cord-014516-r59usk02 1075 8 worldwilde worldwilde NNP cord-014516-r59usk02 1075 9 , , , cord-014516-r59usk02 1075 10 including include VBG cord-014516-r59usk02 1075 11 many many JJ cord-014516-r59usk02 1075 12 European european JJ cord-014516-r59usk02 1075 13 countries country NNS cord-014516-r59usk02 1075 14 , , , cord-014516-r59usk02 1075 15 possibly possibly RB cord-014516-r59usk02 1075 16 due due JJ cord-014516-r59usk02 1075 17 to to IN cord-014516-r59usk02 1075 18 climatic climatic JJ cord-014516-r59usk02 1075 19 factors factor NNS cord-014516-r59usk02 1075 20 , , , cord-014516-r59usk02 1075 21 presence presence NN cord-014516-r59usk02 1075 22 of of IN cord-014516-r59usk02 1075 23 foxes fox NNS cord-014516-r59usk02 1075 24 ( ( -LRB- cord-014516-r59usk02 1075 25 acting act VBG cord-014516-r59usk02 1075 26 as as IN cord-014516-r59usk02 1075 27 reservoir reservoir NN cord-014516-r59usk02 1075 28 ) ) -RRB- cord-014516-r59usk02 1075 29 or or CC cord-014516-r59usk02 1075 30 more more RBR cord-014516-r59usk02 1075 31 simply simply RB cord-014516-r59usk02 1075 32 , , , cord-014516-r59usk02 1075 33 to to IN cord-014516-r59usk02 1075 34 the the DT cord-014516-r59usk02 1075 35 availability availability NN cord-014516-r59usk02 1075 36 of of IN cord-014516-r59usk02 1075 37 more more RBR cord-014516-r59usk02 1075 38 accurate accurate JJ cord-014516-r59usk02 1075 39 diagnostic diagnostic JJ cord-014516-r59usk02 1075 40 methods method NNS cord-014516-r59usk02 1075 41 . . . cord-014516-r59usk02 1076 1 Although although IN cord-014516-r59usk02 1076 2 detection detection NN cord-014516-r59usk02 1076 3 of of IN cord-014516-r59usk02 1076 4 the the DT cord-014516-r59usk02 1076 5 first first JJ cord-014516-r59usk02 1076 6 - - HYPH cord-014516-r59usk02 1076 7 stage stage NN cord-014516-r59usk02 1076 8 larvae larva NNS cord-014516-r59usk02 1076 9 ( ( -LRB- cord-014516-r59usk02 1076 10 L1 L1 NNP cord-014516-r59usk02 1076 11 ) ) -RRB- cord-014516-r59usk02 1076 12 using use VBG cord-014516-r59usk02 1076 13 the the DT cord-014516-r59usk02 1076 14 Baermann Baermann NNP cord-014516-r59usk02 1076 15 technique technique NN cord-014516-r59usk02 1076 16 on on IN cord-014516-r59usk02 1076 17 faecal faecal JJ cord-014516-r59usk02 1076 18 samples sample NNS cord-014516-r59usk02 1076 19 ( ( -LRB- cord-014516-r59usk02 1076 20 preferably preferably RB cord-014516-r59usk02 1076 21 collected collect VBN cord-014516-r59usk02 1076 22 over over IN cord-014516-r59usk02 1076 23 three three CD cord-014516-r59usk02 1076 24 consecutive consecutive JJ cord-014516-r59usk02 1076 25 days day NNS cord-014516-r59usk02 1076 26 ) ) -RRB- cord-014516-r59usk02 1076 27 remains remain VBZ cord-014516-r59usk02 1076 28 the the DT cord-014516-r59usk02 1076 29 gold gold NN cord-014516-r59usk02 1076 30 standard standard NN cord-014516-r59usk02 1076 31 , , , cord-014516-r59usk02 1076 32 recently recently RB cord-014516-r59usk02 1076 33 developed develop VBD cord-014516-r59usk02 1076 34 serological serological JJ cord-014516-r59usk02 1076 35 and and CC cord-014516-r59usk02 1076 36 molecular molecular JJ cord-014516-r59usk02 1076 37 tests test NNS cord-014516-r59usk02 1076 38 ( ( -LRB- cord-014516-r59usk02 1076 39 quantitative quantitative JJ cord-014516-r59usk02 1076 40 polymerase polymerase NN cord-014516-r59usk02 1076 41 chain chain NN cord-014516-r59usk02 1076 42 reaction reaction NN cord-014516-r59usk02 1076 43 , , , cord-014516-r59usk02 1076 44 qPCR qPCR NNP cord-014516-r59usk02 1076 45 ) ) -RRB- cord-014516-r59usk02 1076 46 are be VBP cord-014516-r59usk02 1076 47 now now RB cord-014516-r59usk02 1076 48 available available JJ cord-014516-r59usk02 1076 49 . . . cord-014516-r59usk02 1077 1 Until until IN cord-014516-r59usk02 1077 2 now now RB cord-014516-r59usk02 1077 3 , , , cord-014516-r59usk02 1077 4 the the DT cord-014516-r59usk02 1077 5 prevalence prevalence NN cord-014516-r59usk02 1077 6 of of IN cord-014516-r59usk02 1077 7 canine canine JJ cord-014516-r59usk02 1077 8 angiostrongylosis angiostrongylosis NN cord-014516-r59usk02 1077 9 among among IN cord-014516-r59usk02 1077 10 healthy healthy JJ cord-014516-r59usk02 1077 11 and and CC cord-014516-r59usk02 1077 12 coughing cough VBG cord-014516-r59usk02 1077 13 dogs dog NNS cord-014516-r59usk02 1077 14 in in IN cord-014516-r59usk02 1077 15 Belgium Belgium NNP cord-014516-r59usk02 1077 16 was be VBD cord-014516-r59usk02 1077 17 unknown unknown JJ cord-014516-r59usk02 1077 18 . . . cord-014516-r59usk02 1078 1 The the DT cord-014516-r59usk02 1078 2 aims aim NNS cord-014516-r59usk02 1078 3 of of IN cord-014516-r59usk02 1078 4 the the DT cord-014516-r59usk02 1078 5 present present JJ cord-014516-r59usk02 1078 6 study study NN cord-014516-r59usk02 1078 7 were be VBD cord-014516-r59usk02 1078 8 ( ( -LRB- cord-014516-r59usk02 1078 9 1 1 CD cord-014516-r59usk02 1078 10 ) ) -RRB- cord-014516-r59usk02 1078 11 to to TO cord-014516-r59usk02 1078 12 describe describe VB cord-014516-r59usk02 1078 13 a a DT cord-014516-r59usk02 1078 14 clinical clinical JJ cord-014516-r59usk02 1078 15 series series NN cord-014516-r59usk02 1078 16 of of IN cord-014516-r59usk02 1078 17 recent recent JJ cord-014516-r59usk02 1078 18 autochtonous autochtonous JJ cord-014516-r59usk02 1078 19 cases case NNS cord-014516-r59usk02 1078 20 and and CC cord-014516-r59usk02 1078 21 ( ( -LRB- cord-014516-r59usk02 1078 22 2 2 LS cord-014516-r59usk02 1078 23 ) ) -RRB- cord-014516-r59usk02 1078 24 to to TO cord-014516-r59usk02 1078 25 retrospectively retrospectively RB cord-014516-r59usk02 1078 26 assess assess VB cord-014516-r59usk02 1078 27 Angiostrongylus Angiostrongylus NNP cord-014516-r59usk02 1078 28 vasorum vasorum NN cord-014516-r59usk02 1078 29 qPCR qPCR NNP cord-014516-r59usk02 1078 30 in in IN cord-014516-r59usk02 1078 31 bronchoalveolar bronchoalveolar NNP cord-014516-r59usk02 1078 32 lavage lavage NN cord-014516-r59usk02 1078 33 fluid fluid NN cord-014516-r59usk02 1078 34 ( ( -LRB- cord-014516-r59usk02 1078 35 BALF BALF NNP cord-014516-r59usk02 1078 36 ) ) -RRB- cord-014516-r59usk02 1078 37 samples sample NNS cord-014516-r59usk02 1078 38 , , , cord-014516-r59usk02 1078 39 collected collect VBN cord-014516-r59usk02 1078 40 over over IN cord-014516-r59usk02 1078 41 the the DT cord-014516-r59usk02 1078 42 last last JJ cord-014516-r59usk02 1078 43 7 7 CD cord-014516-r59usk02 1078 44 years year NNS cord-014516-r59usk02 1078 45 from from IN cord-014516-r59usk02 1078 46 a a DT cord-014516-r59usk02 1078 47 larger large JJR cord-014516-r59usk02 1078 48 series series NN cord-014516-r59usk02 1078 49 of of IN cord-014516-r59usk02 1078 50 dogs dog NNS cord-014516-r59usk02 1078 51 , , , cord-014516-r59usk02 1078 52 healthy healthy JJ cord-014516-r59usk02 1078 53 or or CC cord-014516-r59usk02 1078 54 with with IN cord-014516-r59usk02 1078 55 other other JJ cord-014516-r59usk02 1078 56 respiratory respiratory JJ cord-014516-r59usk02 1078 57 conditions condition NNS cord-014516-r59usk02 1078 58 , , , cord-014516-r59usk02 1078 59 in in IN cord-014516-r59usk02 1078 60 order order NN cord-014516-r59usk02 1078 61 to to TO cord-014516-r59usk02 1078 62 investigate investigate VB cord-014516-r59usk02 1078 63 the the DT cord-014516-r59usk02 1078 64 past past JJ cord-014516-r59usk02 1078 65 prevalence prevalence NN cord-014516-r59usk02 1078 66 of of IN cord-014516-r59usk02 1078 67 the the DT cord-014516-r59usk02 1078 68 disease disease NN cord-014516-r59usk02 1078 69 in in IN cord-014516-r59usk02 1078 70 Belgium Belgium NNP cord-014516-r59usk02 1078 71 . . . cord-014516-r59usk02 1079 1 Seven seven CD cord-014516-r59usk02 1079 2 dogs dog NNS cord-014516-r59usk02 1079 3 , , , cord-014516-r59usk02 1079 4 living live VBG cord-014516-r59usk02 1079 5 in in IN cord-014516-r59usk02 1079 6 Southern southern JJ cord-014516-r59usk02 1079 7 or or CC cord-014516-r59usk02 1079 8 Eastern Eastern NNP cord-014516-r59usk02 1079 9 Belgium Belgium NNP cord-014516-r59usk02 1079 10 , , , cord-014516-r59usk02 1079 11 were be VBD cord-014516-r59usk02 1079 12 recently recently RB cord-014516-r59usk02 1079 13 diagnosed diagnose VBN cord-014516-r59usk02 1079 14 as as IN cord-014516-r59usk02 1079 15 having have VBG cord-014516-r59usk02 1079 16 angiostrongylosis angiostrongylosis NN cord-014516-r59usk02 1079 17 ( ( -LRB- cord-014516-r59usk02 1079 18 mean mean VB cord-014516-r59usk02 1079 19 age= age= NNP cord-014516-r59usk02 1079 20 2.3 2.3 CD cord-014516-r59usk02 1079 21 y y NN cord-014516-r59usk02 1079 22 , , , cord-014516-r59usk02 1079 23 mean mean JJ cord-014516-r59usk02 1079 24 body body NN cord-014516-r59usk02 1079 25 weight= weight= NN cord-014516-r59usk02 1079 26 15.3 15.3 CD cord-014516-r59usk02 1079 27 kg kg NNP cord-014516-r59usk02 1079 28 ) ) -RRB- cord-014516-r59usk02 1079 29 . . . cord-014516-r59usk02 1080 1 They -PRON- PRP cord-014516-r59usk02 1080 2 all all DT cord-014516-r59usk02 1080 3 presented present VBN cord-014516-r59usk02 1080 4 with with IN cord-014516-r59usk02 1080 5 respiratory respiratory JJ cord-014516-r59usk02 1080 6 signs sign NNS cord-014516-r59usk02 1080 7 of of IN cord-014516-r59usk02 1080 8 variable variable JJ cord-014516-r59usk02 1080 9 severity severity NN cord-014516-r59usk02 1080 10 . . . cord-014516-r59usk02 1081 1 In in IN cord-014516-r59usk02 1081 2 5 5 CD cord-014516-r59usk02 1081 3 dogs dog NNS cord-014516-r59usk02 1081 4 , , , cord-014516-r59usk02 1081 5 BALF BALF NNP cord-014516-r59usk02 1081 6 was be VBD cord-014516-r59usk02 1081 7 obtained obtain VBN cord-014516-r59usk02 1081 8 and and CC cord-014516-r59usk02 1081 9 qPCR qPCR NNP cord-014516-r59usk02 1081 10 was be VBD cord-014516-r59usk02 1081 11 positive positive JJ cord-014516-r59usk02 1081 12 in in IN cord-014516-r59usk02 1081 13 all all DT cord-014516-r59usk02 1081 14 of of IN cord-014516-r59usk02 1081 15 them -PRON- PRP cord-014516-r59usk02 1081 16 , , , cord-014516-r59usk02 1081 17 at at IN cord-014516-r59usk02 1081 18 moderate moderate JJ cord-014516-r59usk02 1081 19 or or CC cord-014516-r59usk02 1081 20 high high JJ cord-014516-r59usk02 1081 21 level level NN cord-014516-r59usk02 1082 1 ( ( -LRB- cord-014516-r59usk02 1082 2 Ct Ct NNP cord-014516-r59usk02 1082 3 from from IN cord-014516-r59usk02 1082 4 26,7 26,7 CD cord-014516-r59usk02 1082 5 to to IN cord-014516-r59usk02 1082 6 29,6 29,6 CD cord-014516-r59usk02 1082 7 ) ) -RRB- cord-014516-r59usk02 1082 8 while while IN cord-014516-r59usk02 1082 9 larvae larva NNS cord-014516-r59usk02 1082 10 were be VBD cord-014516-r59usk02 1082 11 detected detect VBN cord-014516-r59usk02 1082 12 in in IN cord-014516-r59usk02 1082 13 the the DT cord-014516-r59usk02 1082 14 faeces faece NNS cord-014516-r59usk02 1082 15 of of IN cord-014516-r59usk02 1082 16 only only RB cord-014516-r59usk02 1082 17 2 2 CD cord-014516-r59usk02 1082 18 animals animal NNS cord-014516-r59usk02 1082 19 . . . cord-014516-r59usk02 1083 1 In in IN cord-014516-r59usk02 1083 2 the the DT cord-014516-r59usk02 1083 3 remaining remain VBG cord-014516-r59usk02 1083 4 two two CD cord-014516-r59usk02 1083 5 dogs dog NNS cord-014516-r59usk02 1083 6 , , , cord-014516-r59usk02 1083 7 no no DT cord-014516-r59usk02 1083 8 BALF BALF NNP cord-014516-r59usk02 1083 9 was be VBD cord-014516-r59usk02 1083 10 obtained obtain VBN cord-014516-r59usk02 1083 11 , , , cord-014516-r59usk02 1083 12 but but CC cord-014516-r59usk02 1083 13 coproscopy coproscopy NNP cord-014516-r59usk02 1083 14 was be VBD cord-014516-r59usk02 1083 15 positive positive JJ cord-014516-r59usk02 1083 16 . . . cord-014516-r59usk02 1084 1 All all DT cord-014516-r59usk02 1084 2 dogs dog NNS cord-014516-r59usk02 1084 3 responded respond VBD cord-014516-r59usk02 1084 4 to to IN cord-014516-r59usk02 1084 5 medical medical JJ cord-014516-r59usk02 1084 6 treatment treatment NN cord-014516-r59usk02 1084 7 , , , cord-014516-r59usk02 1084 8 consisting consist VBG cord-014516-r59usk02 1084 9 in in IN cord-014516-r59usk02 1084 10 a a DT cord-014516-r59usk02 1084 11 3-week 3-week JJ cord-014516-r59usk02 1084 12 course course NN cord-014516-r59usk02 1084 13 of of IN cord-014516-r59usk02 1084 14 fenbendazole fenbendazole NN cord-014516-r59usk02 1084 15 and/or and/or CC cord-014516-r59usk02 1084 16 two two CD cord-014516-r59usk02 1084 17 spot spot NN cord-014516-r59usk02 1084 18 - - HYPH cord-014516-r59usk02 1084 19 on on RP cord-014516-r59usk02 1084 20 application application NN cord-014516-r59usk02 1084 21 of of IN cord-014516-r59usk02 1084 22 moxidectin moxidectin NNS cord-014516-r59usk02 1084 23 at at IN cord-014516-r59usk02 1084 24 1-month 1-month CD cord-014516-r59usk02 1084 25 interval interval NN cord-014516-r59usk02 1084 26 . . . cord-014516-r59usk02 1085 1 BALF BALF NNP cord-014516-r59usk02 1085 2 samples sample NNS cord-014516-r59usk02 1085 3 were be VBD cord-014516-r59usk02 1085 4 collected collect VBN cord-014516-r59usk02 1085 5 between between IN cord-014516-r59usk02 1085 6 2008 2008 CD cord-014516-r59usk02 1085 7 and and CC cord-014516-r59usk02 1085 8 2014 2014 CD cord-014516-r59usk02 1085 9 from from IN cord-014516-r59usk02 1085 10 10 10 CD cord-014516-r59usk02 1085 11 asymptomatic asymptomatic JJ cord-014516-r59usk02 1085 12 client client NN cord-014516-r59usk02 1085 13 - - HYPH cord-014516-r59usk02 1085 14 owned own VBN cord-014516-r59usk02 1085 15 dogs dog NNS cord-014516-r59usk02 1085 16 and and CC cord-014516-r59usk02 1085 17 55 55 CD cord-014516-r59usk02 1085 18 dogs dog NNS cord-014516-r59usk02 1085 19 with with IN cord-014516-r59usk02 1085 20 various various JJ cord-014516-r59usk02 1085 21 respiratory respiratory JJ cord-014516-r59usk02 1085 22 conditions condition NNS cord-014516-r59usk02 1085 23 , , , cord-014516-r59usk02 1085 24 including include VBG cord-014516-r59usk02 1085 25 16 16 CD cord-014516-r59usk02 1085 26 dogs dog NNS cord-014516-r59usk02 1085 27 with with IN cord-014516-r59usk02 1085 28 confirmed confirm VBN cord-014516-r59usk02 1085 29 bordetellosis bordetellosis NN cord-014516-r59usk02 1085 30 , , , cord-014516-r59usk02 1085 31 18 18 CD cord-014516-r59usk02 1085 32 dogs dog NNS cord-014516-r59usk02 1085 33 with with IN cord-014516-r59usk02 1085 34 eosinophilic eosinophilic JJ cord-014516-r59usk02 1085 35 bronchopneumopathy bronchopneumopathy NNP cord-014516-r59usk02 1085 36 ( ( -LRB- cord-014516-r59usk02 1085 37 EBP EBP NNP cord-014516-r59usk02 1085 38 ) ) -RRB- cord-014516-r59usk02 1085 39 , , , cord-014516-r59usk02 1085 40 8 8 CD cord-014516-r59usk02 1085 41 dogs dog NNS cord-014516-r59usk02 1085 42 with with IN cord-014516-r59usk02 1085 43 chronic chronic JJ cord-014516-r59usk02 1085 44 bronchitis bronchitis NN cord-014516-r59usk02 1085 45 and and CC cord-014516-r59usk02 1085 46 13 13 CD cord-014516-r59usk02 1085 47 dogs dog NNS cord-014516-r59usk02 1085 48 with with IN cord-014516-r59usk02 1085 49 bacterial bacterial JJ cord-014516-r59usk02 1085 50 bronchopneumonia bronchopneumonia NN cord-014516-r59usk02 1085 51 , , , cord-014516-r59usk02 1085 52 and and CC cord-014516-r59usk02 1085 53 were be VBD cord-014516-r59usk02 1085 54 retrospectively retrospectively RB cord-014516-r59usk02 1085 55 assessed assess VBN cord-014516-r59usk02 1085 56 with with IN cord-014516-r59usk02 1085 57 a a DT cord-014516-r59usk02 1085 58 A. A. NNP cord-014516-r59usk02 1085 59 vasorum vasorum NN cord-014516-r59usk02 1085 60 qPCR qpcr NN cord-014516-r59usk02 1085 61 assay assay NN cord-014516-r59usk02 1085 62 . . . cord-014516-r59usk02 1086 1 Amongst amongst IN cord-014516-r59usk02 1086 2 those those DT cord-014516-r59usk02 1086 3 65 65 CD cord-014516-r59usk02 1086 4 dogs dog NNS cord-014516-r59usk02 1086 5 , , , cord-014516-r59usk02 1086 6 only only RB cord-014516-r59usk02 1086 7 one one CD cord-014516-r59usk02 1086 8 BALF BALF NNP cord-014516-r59usk02 1086 9 , , , cord-014516-r59usk02 1086 10 from from IN cord-014516-r59usk02 1086 11 a a DT cord-014516-r59usk02 1086 12 dog dog NN cord-014516-r59usk02 1086 13 with with IN cord-014516-r59usk02 1086 14 EBP EBP NNP cord-014516-r59usk02 1086 15 , , , cord-014516-r59usk02 1086 16 yielded yield VBD cord-014516-r59usk02 1086 17 a a DT cord-014516-r59usk02 1086 18 positive positive JJ cord-014516-r59usk02 1086 19 qPCR qpcr NN cord-014516-r59usk02 1086 20 result result NN cord-014516-r59usk02 1086 21 . . . cord-014516-r59usk02 1087 1 In in IN cord-014516-r59usk02 1087 2 this this DT cord-014516-r59usk02 1087 3 dog dog NN cord-014516-r59usk02 1087 4 , , , cord-014516-r59usk02 1087 5 faecal faecal JJ cord-014516-r59usk02 1087 6 analysis analysis NN cord-014516-r59usk02 1087 7 was be VBD cord-014516-r59usk02 1087 8 negative negative JJ cord-014516-r59usk02 1087 9 . . . cord-014516-r59usk02 1088 1 The the DT cord-014516-r59usk02 1088 2 present present JJ cord-014516-r59usk02 1088 3 data datum NNS cord-014516-r59usk02 1088 4 show show VBP cord-014516-r59usk02 1088 5 that that IN cord-014516-r59usk02 1088 6 , , , cord-014516-r59usk02 1088 7 based base VBN cord-014516-r59usk02 1088 8 on on IN cord-014516-r59usk02 1088 9 BALF BALF NNP cord-014516-r59usk02 1088 10 qPCR qPCR NNP cord-014516-r59usk02 1088 11 and and CC cord-014516-r59usk02 1088 12 coproscopy coproscopy NNP cord-014516-r59usk02 1088 13 , , , cord-014516-r59usk02 1088 14 presence presence NN cord-014516-r59usk02 1088 15 of of IN cord-014516-r59usk02 1088 16 angiostrongylosis angiostrongylosis NN cord-014516-r59usk02 1088 17 in in IN cord-014516-r59usk02 1088 18 healthy healthy JJ cord-014516-r59usk02 1088 19 and and CC cord-014516-r59usk02 1088 20 coughing cough VBG cord-014516-r59usk02 1088 21 dogs dog NNS cord-014516-r59usk02 1088 22 was be VBD cord-014516-r59usk02 1088 23 negligible negligible JJ cord-014516-r59usk02 1088 24 in in IN cord-014516-r59usk02 1088 25 Belgium Belgium NNP cord-014516-r59usk02 1088 26 until until IN cord-014516-r59usk02 1088 27 the the DT cord-014516-r59usk02 1088 28 last last JJ cord-014516-r59usk02 1088 29 12 12 CD cord-014516-r59usk02 1088 30 months month NNS cord-014516-r59usk02 1088 31 . . . cord-014516-r59usk02 1089 1 It -PRON- PRP cord-014516-r59usk02 1089 2 is be VBZ cord-014516-r59usk02 1089 3 now now RB cord-014516-r59usk02 1089 4 considered consider VBN cord-014516-r59usk02 1089 5 as as IN cord-014516-r59usk02 1089 6 an an DT cord-014516-r59usk02 1089 7 emerging emerge VBG cord-014516-r59usk02 1089 8 condition condition NN cord-014516-r59usk02 1089 9 and and CC cord-014516-r59usk02 1089 10 must must MD cord-014516-r59usk02 1089 11 be be VB cord-014516-r59usk02 1089 12 included include VBN cord-014516-r59usk02 1089 13 in in IN cord-014516-r59usk02 1089 14 the the DT cord-014516-r59usk02 1089 15 differential differential JJ cord-014516-r59usk02 1089 16 diagnosis diagnosis NN cord-014516-r59usk02 1089 17 in in IN cord-014516-r59usk02 1089 18 coughing cough VBG cord-014516-r59usk02 1089 19 dogs dog NNS cord-014516-r59usk02 1089 20 . . . cord-014516-r59usk02 1090 1 The the DT cord-014516-r59usk02 1090 2 present present JJ cord-014516-r59usk02 1090 3 results result NNS cord-014516-r59usk02 1090 4 also also RB cord-014516-r59usk02 1090 5 support support VBP cord-014516-r59usk02 1090 6 that that IN cord-014516-r59usk02 1090 7 qPCR qPCR NNP cord-014516-r59usk02 1090 8 detection detection NN cord-014516-r59usk02 1090 9 of of IN cord-014516-r59usk02 1090 10 A. a. NN cord-014516-r59usk02 1090 11 vasorum vasorum NN cord-014516-r59usk02 1090 12 in in IN cord-014516-r59usk02 1090 13 BALF BALF NNP cord-014516-r59usk02 1090 14 , , , cord-014516-r59usk02 1090 15 when when WRB cord-014516-r59usk02 1090 16 available available JJ cord-014516-r59usk02 1090 17 , , , cord-014516-r59usk02 1090 18 is be VBZ cord-014516-r59usk02 1090 19 an an DT cord-014516-r59usk02 1090 20 adequate adequate JJ cord-014516-r59usk02 1090 21 and and CC cord-014516-r59usk02 1090 22 reliable reliable JJ cord-014516-r59usk02 1090 23 detection detection NN cord-014516-r59usk02 1090 24 technique technique NN cord-014516-r59usk02 1090 25 . . . cord-014516-r59usk02 1091 1 No no DT cord-014516-r59usk02 1091 2 conflicts conflict NNS cord-014516-r59usk02 1091 3 of of IN cord-014516-r59usk02 1091 4 interest interest NN cord-014516-r59usk02 1091 5 reported report VBN cord-014516-r59usk02 1091 6 . . . cord-014516-r59usk02 1092 1 Ligneous Ligneous NNP cord-014516-r59usk02 1092 2 membranitis membranitis NNP cord-014516-r59usk02 1092 3 is be VBZ cord-014516-r59usk02 1092 4 a a DT cord-014516-r59usk02 1092 5 rare rare JJ cord-014516-r59usk02 1092 6 chronic chronic JJ cord-014516-r59usk02 1092 7 inflammatory inflammatory JJ cord-014516-r59usk02 1092 8 disease disease NN cord-014516-r59usk02 1092 9 associated associate VBN cord-014516-r59usk02 1092 10 with with IN cord-014516-r59usk02 1092 11 congenital congenital JJ cord-014516-r59usk02 1092 12 plasminogen plasminogen NN cord-014516-r59usk02 1092 13 deficiency deficiency NN cord-014516-r59usk02 1092 14 . . . cord-014516-r59usk02 1093 1 It -PRON- PRP cord-014516-r59usk02 1093 2 has have VBZ cord-014516-r59usk02 1093 3 only only RB cord-014516-r59usk02 1093 4 been be VBN cord-014516-r59usk02 1093 5 described describe VBN cord-014516-r59usk02 1093 6 in in IN cord-014516-r59usk02 1093 7 six six CD cord-014516-r59usk02 1093 8 unrelated unrelated JJ cord-014516-r59usk02 1093 9 dogs dog NNS cord-014516-r59usk02 1093 10 . . . cord-014516-r59usk02 1094 1 The the DT cord-014516-r59usk02 1094 2 objective objective NN cord-014516-r59usk02 1094 3 of of IN cord-014516-r59usk02 1094 4 this this DT cord-014516-r59usk02 1094 5 study study NN cord-014516-r59usk02 1094 6 is be VBZ cord-014516-r59usk02 1094 7 to to TO cord-014516-r59usk02 1094 8 report report VB cord-014516-r59usk02 1094 9 the the DT cord-014516-r59usk02 1094 10 presentation presentation NN cord-014516-r59usk02 1094 11 , , , cord-014516-r59usk02 1094 12 clinicopathological clinicopathological NNP cord-014516-r59usk02 1094 13 and and CC cord-014516-r59usk02 1094 14 post post AFX cord-014516-r59usk02 1094 15 mortem mortem NN cord-014516-r59usk02 1094 16 findings finding NNS cord-014516-r59usk02 1094 17 in in IN cord-014516-r59usk02 1094 18 three three CD cord-014516-r59usk02 1094 19 related relate VBN cord-014516-r59usk02 1094 20 Scottish scottish JJ cord-014516-r59usk02 1094 21 terrier terrier NN cord-014516-r59usk02 1094 22 puppies puppy NNS cord-014516-r59usk02 1094 23 with with IN cord-014516-r59usk02 1094 24 ligneous ligneous NNP cord-014516-r59usk02 1094 25 membranitis membranitis NNP cord-014516-r59usk02 1094 26 . . . cord-014516-r59usk02 1095 1 Ligneous Ligneous NNP cord-014516-r59usk02 1095 2 membranitis membranitis NNP cord-014516-r59usk02 1095 3 is be VBZ cord-014516-r59usk02 1095 4 well well RB cord-014516-r59usk02 1095 5 described describe VBN cord-014516-r59usk02 1095 6 in in IN cord-014516-r59usk02 1095 7 humans human NNS cord-014516-r59usk02 1095 8 , , , cord-014516-r59usk02 1095 9 where where WRB cord-014516-r59usk02 1095 10 it -PRON- PRP cord-014516-r59usk02 1095 11 is be VBZ cord-014516-r59usk02 1095 12 inherited inherit VBN cord-014516-r59usk02 1095 13 in in IN cord-014516-r59usk02 1095 14 an an DT cord-014516-r59usk02 1095 15 autosomal autosomal JJ cord-014516-r59usk02 1095 16 recessive recessive JJ cord-014516-r59usk02 1095 17 manner manner NN cord-014516-r59usk02 1095 18 . . . cord-014516-r59usk02 1096 1 Patients patient NNS cord-014516-r59usk02 1096 2 commonly commonly RB cord-014516-r59usk02 1096 3 present present JJ cord-014516-r59usk02 1096 4 as as IN cord-014516-r59usk02 1096 5 infants infant NNS cord-014516-r59usk02 1096 6 . . . cord-014516-r59usk02 1097 1 Ocular ocular JJ cord-014516-r59usk02 1097 2 , , , cord-014516-r59usk02 1097 3 oral oral JJ cord-014516-r59usk02 1097 4 and and CC cord-014516-r59usk02 1097 5 genital genital JJ cord-014516-r59usk02 1097 6 lesions lesion NNS cord-014516-r59usk02 1097 7 are be VBP cord-014516-r59usk02 1097 8 most most RBS cord-014516-r59usk02 1097 9 common common JJ cord-014516-r59usk02 1097 10 , , , cord-014516-r59usk02 1097 11 but but CC cord-014516-r59usk02 1097 12 other other JJ cord-014516-r59usk02 1097 13 organs organ NNS cord-014516-r59usk02 1097 14 are be VBP cord-014516-r59usk02 1097 15 occasionally occasionally RB cord-014516-r59usk02 1097 16 involved involve VBN cord-014516-r59usk02 1097 17 and and CC cord-014516-r59usk02 1097 18 congenital congenital JJ cord-014516-r59usk02 1097 19 obstructive obstructive JJ cord-014516-r59usk02 1097 20 hydrocephalus hydrocephalus NN cord-014516-r59usk02 1097 21 is be VBZ cord-014516-r59usk02 1097 22 reported report VBN cord-014516-r59usk02 1097 23 in in IN cord-014516-r59usk02 1097 24 some some DT cord-014516-r59usk02 1097 25 individuals individual NNS cord-014516-r59usk02 1097 26 . . . cord-014516-r59usk02 1098 1 Numerous numerous JJ cord-014516-r59usk02 1098 2 mutations mutation NNS cord-014516-r59usk02 1098 3 and and CC cord-014516-r59usk02 1098 4 polymorphisms polymorphism NNS cord-014516-r59usk02 1098 5 in in IN cord-014516-r59usk02 1098 6 the the DT cord-014516-r59usk02 1098 7 plasminogen plasminogen NN cord-014516-r59usk02 1098 8 gene gene NN cord-014516-r59usk02 1098 9 have have VBP cord-014516-r59usk02 1098 10 been be VBN cord-014516-r59usk02 1098 11 identified identify VBN cord-014516-r59usk02 1098 12 in in IN cord-014516-r59usk02 1098 13 affected affect VBN cord-014516-r59usk02 1098 14 individuals individual NNS cord-014516-r59usk02 1098 15 . . . cord-014516-r59usk02 1099 1 The the DT cord-014516-r59usk02 1099 2 affected affected JJ cord-014516-r59usk02 1099 3 Scottish scottish JJ cord-014516-r59usk02 1099 4 Terriers Terriers NNPS cord-014516-r59usk02 1099 5 ( ( -LRB- cord-014516-r59usk02 1099 6 two two CD cord-014516-r59usk02 1099 7 male male NN cord-014516-r59usk02 1099 8 and and CC cord-014516-r59usk02 1099 9 one one CD cord-014516-r59usk02 1099 10 female female NN cord-014516-r59usk02 1099 11 ) ) -RRB- cord-014516-r59usk02 1099 12 presented present VBN cord-014516-r59usk02 1099 13 at at IN cord-014516-r59usk02 1099 14 2 2 CD cord-014516-r59usk02 1099 15 months month NNS cord-014516-r59usk02 1099 16 of of IN cord-014516-r59usk02 1099 17 age age NN cord-014516-r59usk02 1099 18 with with IN cord-014516-r59usk02 1099 19 severe severe JJ cord-014516-r59usk02 1099 20 proliferative proliferative JJ cord-014516-r59usk02 1099 21 and and CC cord-014516-r59usk02 1099 22 ulcerative ulcerative JJ cord-014516-r59usk02 1099 23 conjunctivitis conjunctivitis NN cord-014516-r59usk02 1099 24 and and CC cord-014516-r59usk02 1099 25 gingivitis gingivitis NN cord-014516-r59usk02 1099 26 / / SYM cord-014516-r59usk02 1099 27 stomatitis stomatitis NN cord-014516-r59usk02 1099 28 ; ; : cord-014516-r59usk02 1099 29 biopsy biopsy NNP cord-014516-r59usk02 1099 30 confirmed confirm VBD cord-014516-r59usk02 1099 31 ligneous ligneous NNP cord-014516-r59usk02 1099 32 membranitis membranitis NNP cord-014516-r59usk02 1099 33 . . . cord-014516-r59usk02 1100 1 Other other JJ cord-014516-r59usk02 1100 2 clinical clinical JJ cord-014516-r59usk02 1100 3 signs sign NNS cord-014516-r59usk02 1100 4 included include VBD cord-014516-r59usk02 1100 5 increased increase VBN cord-014516-r59usk02 1100 6 upper upper JJ cord-014516-r59usk02 1100 7 respiratory respiratory JJ cord-014516-r59usk02 1100 8 tract tract NN cord-014516-r59usk02 1100 9 noise noise NN cord-014516-r59usk02 1100 10 , , , cord-014516-r59usk02 1100 11 nasal nasal NN cord-014516-r59usk02 1100 12 discharge discharge NN cord-014516-r59usk02 1100 13 and and CC cord-014516-r59usk02 1100 14 lymphadenopathy lymphadenopathy NN cord-014516-r59usk02 1100 15 . . . cord-014516-r59usk02 1101 1 One one CD cord-014516-r59usk02 1101 2 male male NN cord-014516-r59usk02 1101 3 was be VBD cord-014516-r59usk02 1101 4 cryptorchid cryptorchid JJ cord-014516-r59usk02 1101 5 . . . cord-014516-r59usk02 1102 1 Clinical clinical JJ cord-014516-r59usk02 1102 2 pathological pathological JJ cord-014516-r59usk02 1102 3 findings finding NNS cord-014516-r59usk02 1102 4 included include VBD cord-014516-r59usk02 1102 5 neutrophilia neutrophilia NNP cord-014516-r59usk02 1102 6 , , , cord-014516-r59usk02 1102 7 proteinuria proteinuria NN cord-014516-r59usk02 1102 8 and and CC cord-014516-r59usk02 1102 9 hypoalbuinaemia hypoalbuinaemia NN cord-014516-r59usk02 1102 10 . . . cord-014516-r59usk02 1103 1 Serum serum NN cord-014516-r59usk02 1103 2 plasminogen plasminogen NN cord-014516-r59usk02 1103 3 activity activity NN cord-014516-r59usk02 1103 4 was be VBD cord-014516-r59usk02 1103 5 measured measure VBN cord-014516-r59usk02 1103 6 in in IN cord-014516-r59usk02 1103 7 two two CD cord-014516-r59usk02 1103 8 dogs dog NNS cord-014516-r59usk02 1103 9 , , , cord-014516-r59usk02 1103 10 and and CC cord-014516-r59usk02 1103 11 was be VBD cord-014516-r59usk02 1103 12 low low JJ cord-014516-r59usk02 1103 13 in in IN cord-014516-r59usk02 1103 14 one one CD cord-014516-r59usk02 1103 15 . . . cord-014516-r59usk02 1104 1 The the DT cord-014516-r59usk02 1104 2 dam dam NN cord-014516-r59usk02 1104 3 and and CC cord-014516-r59usk02 1104 4 sire sire NN cord-014516-r59usk02 1104 5 of of IN cord-014516-r59usk02 1104 6 the the DT cord-014516-r59usk02 1104 7 affected affect VBN cord-014516-r59usk02 1104 8 dogs dog NNS cord-014516-r59usk02 1104 9 had have VBD cord-014516-r59usk02 1104 10 normal normal JJ cord-014516-r59usk02 1104 11 serum serum NN cord-014516-r59usk02 1104 12 plasminogen plasminogen NN cord-014516-r59usk02 1104 13 activity activity NN cord-014516-r59usk02 1104 14 and and CC cord-014516-r59usk02 1104 15 no no DT cord-014516-r59usk02 1104 16 history history NN cord-014516-r59usk02 1104 17 or or CC cord-014516-r59usk02 1104 18 clinical clinical JJ cord-014516-r59usk02 1104 19 signs sign NNS cord-014516-r59usk02 1104 20 consistent consistent JJ cord-014516-r59usk02 1104 21 with with IN cord-014516-r59usk02 1104 22 ligneous ligneous NNP cord-014516-r59usk02 1104 23 membranitis membranitis NNP cord-014516-r59usk02 1104 24 . . . cord-014516-r59usk02 1105 1 No no DT cord-014516-r59usk02 1105 2 significant significant JJ cord-014516-r59usk02 1105 3 clinical clinical JJ cord-014516-r59usk02 1105 4 improvement improvement NN cord-014516-r59usk02 1105 5 was be VBD cord-014516-r59usk02 1105 6 evident evident JJ cord-014516-r59usk02 1105 7 following follow VBG cord-014516-r59usk02 1105 8 treatment treatment NN cord-014516-r59usk02 1105 9 with with IN cord-014516-r59usk02 1105 10 antibiotics antibiotic NNS cord-014516-r59usk02 1105 11 , , , cord-014516-r59usk02 1105 12 glucocorticoids glucocorticoid NNS cord-014516-r59usk02 1105 13 , , , cord-014516-r59usk02 1105 14 topical topical JJ cord-014516-r59usk02 1105 15 ciclosporin ciclosporin NN cord-014516-r59usk02 1105 16 or or CC cord-014516-r59usk02 1105 17 heparin heparin NN cord-014516-r59usk02 1105 18 . . . cord-014516-r59usk02 1106 1 One one CD cord-014516-r59usk02 1106 2 dog dog NN cord-014516-r59usk02 1106 3 died die VBD cord-014516-r59usk02 1106 4 of of IN cord-014516-r59usk02 1106 5 cardiopulmonary cardiopulmonary JJ cord-014516-r59usk02 1106 6 arrest arrest NN cord-014516-r59usk02 1106 7 in in IN cord-014516-r59usk02 1106 8 the the DT cord-014516-r59usk02 1106 9 hospital hospital NN cord-014516-r59usk02 1106 10 and and CC cord-014516-r59usk02 1106 11 the the DT cord-014516-r59usk02 1106 12 two two CD cord-014516-r59usk02 1106 13 other other JJ cord-014516-r59usk02 1106 14 dogs dog NNS cord-014516-r59usk02 1106 15 were be VBD cord-014516-r59usk02 1106 16 euthanized euthanize VBN cord-014516-r59usk02 1106 17 due due IN cord-014516-r59usk02 1106 18 to to IN cord-014516-r59usk02 1106 19 progressive progressive JJ cord-014516-r59usk02 1106 20 clinical clinical JJ cord-014516-r59usk02 1106 21 signs sign NNS cord-014516-r59usk02 1106 22 . . . cord-014516-r59usk02 1107 1 Post post JJ cord-014516-r59usk02 1107 2 - - JJ cord-014516-r59usk02 1107 3 mortem mortem JJ cord-014516-r59usk02 1107 4 evaluation evaluation NN cord-014516-r59usk02 1107 5 of of IN cord-014516-r59usk02 1107 6 the the DT cord-014516-r59usk02 1107 7 affected affect VBN cord-014516-r59usk02 1107 8 dogs dog NNS cord-014516-r59usk02 1107 9 revealed reveal VBD cord-014516-r59usk02 1107 10 multiple multiple JJ cord-014516-r59usk02 1107 11 abnormalities abnormality NNS cord-014516-r59usk02 1107 12 including include VBG cord-014516-r59usk02 1107 13 severe severe JJ cord-014516-r59usk02 1107 14 proliferative proliferative JJ cord-014516-r59usk02 1107 15 fibrinous fibrinous JJ cord-014516-r59usk02 1107 16 lesions lesion NNS cord-014516-r59usk02 1107 17 affecting affect VBG cord-014516-r59usk02 1107 18 the the DT cord-014516-r59usk02 1107 19 trachea trachea NN cord-014516-r59usk02 1107 20 , , , cord-014516-r59usk02 1107 21 larynx larynx NN cord-014516-r59usk02 1107 22 and and CC cord-014516-r59usk02 1107 23 epicardium epicardium NN cord-014516-r59usk02 1107 24 , , , cord-014516-r59usk02 1107 25 and and CC cord-014516-r59usk02 1107 26 multiple multiple JJ cord-014516-r59usk02 1107 27 fibrous fibrous JJ cord-014516-r59usk02 1107 28 adhesions adhesion NNS cord-014516-r59usk02 1107 29 throughout throughout IN cord-014516-r59usk02 1107 30 the the DT cord-014516-r59usk02 1107 31 thoracic thoracic JJ cord-014516-r59usk02 1107 32 and and CC cord-014516-r59usk02 1107 33 abdominal abdominal JJ cord-014516-r59usk02 1107 34 cavities cavity NNS cord-014516-r59usk02 1107 35 . . . cord-014516-r59usk02 1108 1 The the DT cord-014516-r59usk02 1108 2 male male JJ cord-014516-r59usk02 1108 3 dog dog NN cord-014516-r59usk02 1108 4 had have VBD cord-014516-r59usk02 1108 5 internal internal JJ cord-014516-r59usk02 1108 6 hydrocephalus hydrocephalus NN cord-014516-r59usk02 1108 7 and and CC cord-014516-r59usk02 1108 8 lacked lack VBD cord-014516-r59usk02 1108 9 a a DT cord-014516-r59usk02 1108 10 cerebellar cerebellar JJ cord-014516-r59usk02 1108 11 vermis vermis NN cord-014516-r59usk02 1108 12 . . . cord-014516-r59usk02 1109 1 This this DT cord-014516-r59usk02 1109 2 is be VBZ cord-014516-r59usk02 1109 3 the the DT cord-014516-r59usk02 1109 4 first first JJ cord-014516-r59usk02 1109 5 report report NN cord-014516-r59usk02 1109 6 of of IN cord-014516-r59usk02 1109 7 ligneous ligneous NNP cord-014516-r59usk02 1109 8 membranitis membranitis NNP cord-014516-r59usk02 1109 9 in in IN cord-014516-r59usk02 1109 10 related related JJ cord-014516-r59usk02 1109 11 dogs dog NNS cord-014516-r59usk02 1109 12 and and CC cord-014516-r59usk02 1109 13 the the DT cord-014516-r59usk02 1109 14 first first JJ cord-014516-r59usk02 1109 15 report report NN cord-014516-r59usk02 1109 16 in in IN cord-014516-r59usk02 1109 17 Scottish scottish JJ cord-014516-r59usk02 1109 18 Terriers Terriers NNPS cord-014516-r59usk02 1109 19 . . . cord-014516-r59usk02 1110 1 Sequencing sequence VBG cord-014516-r59usk02 1110 2 the the DT cord-014516-r59usk02 1110 3 plasminogen plasminogen NN cord-014516-r59usk02 1110 4 gene gene NN cord-014516-r59usk02 1110 5 in in IN cord-014516-r59usk02 1110 6 the the DT cord-014516-r59usk02 1110 7 affected affect VBN cord-014516-r59usk02 1110 8 dogs dog NNS cord-014516-r59usk02 1110 9 , , , cord-014516-r59usk02 1110 10 their -PRON- PRP$ cord-014516-r59usk02 1110 11 parents parent NNS cord-014516-r59usk02 1110 12 and and CC cord-014516-r59usk02 1110 13 unrelated unrelated JJ cord-014516-r59usk02 1110 14 control control NN cord-014516-r59usk02 1110 15 dogs dog NNS cord-014516-r59usk02 1110 16 to to TO cord-014516-r59usk02 1110 17 identify identify VB cord-014516-r59usk02 1110 18 polymorphisms polymorphism NNS cord-014516-r59usk02 1110 19 or or CC cord-014516-r59usk02 1110 20 mutations mutation NNS cord-014516-r59usk02 1110 21 that that WDT cord-014516-r59usk02 1110 22 may may MD cord-014516-r59usk02 1110 23 be be VB cord-014516-r59usk02 1110 24 associated associate VBN cord-014516-r59usk02 1110 25 with with IN cord-014516-r59usk02 1110 26 ligneous ligneous NNP cord-014516-r59usk02 1110 27 membranitis membranitis NNP cord-014516-r59usk02 1110 28 in in IN cord-014516-r59usk02 1110 29 dogs dog NNS cord-014516-r59usk02 1110 30 is be VBZ cord-014516-r59usk02 1110 31 ongoing ongoing JJ cord-014516-r59usk02 1110 32 . . . cord-014516-r59usk02 1111 1 The the DT cord-014516-r59usk02 1111 2 author author NN cord-014516-r59usk02 1111 3 received receive VBD cord-014516-r59usk02 1111 4 a a DT cord-014516-r59usk02 1111 5 travel travel NN cord-014516-r59usk02 1111 6 scholarship scholarship NN cord-014516-r59usk02 1111 7 from from IN cord-014516-r59usk02 1111 8 Zoetis Zoetis NNP cord-014516-r59usk02 1111 9 to to TO cord-014516-r59usk02 1111 10 attend attend VB cord-014516-r59usk02 1111 11 this this DT cord-014516-r59usk02 1111 12 congress congress NNP cord-014516-r59usk02 1111 13 . . . cord-014516-r59usk02 1112 1 Health health NN cord-014516-r59usk02 1112 2 screening screening NN cord-014516-r59usk02 1112 3 of of IN cord-014516-r59usk02 1112 4 elderly elderly JJ cord-014516-r59usk02 1112 5 dogs dog NNS cord-014516-r59usk02 1112 6 is be VBZ cord-014516-r59usk02 1112 7 often often RB cord-014516-r59usk02 1112 8 recommended recommend VBN cord-014516-r59usk02 1112 9 , , , cord-014516-r59usk02 1112 10 but but CC cord-014516-r59usk02 1112 11 scientific scientific JJ cord-014516-r59usk02 1112 12 information information NN cord-014516-r59usk02 1112 13 on on IN cord-014516-r59usk02 1112 14 clinical clinical JJ cord-014516-r59usk02 1112 15 and and CC cord-014516-r59usk02 1112 16 laboratory laboratory NN cord-014516-r59usk02 1112 17 abnormalities abnormality NNS cord-014516-r59usk02 1112 18 in in IN cord-014516-r59usk02 1112 19 senior senior JJ cord-014516-r59usk02 1112 20 and and CC cord-014516-r59usk02 1112 21 geriatric geriatric JJ cord-014516-r59usk02 1112 22 dogs dog NNS cord-014516-r59usk02 1112 23 is be VBZ cord-014516-r59usk02 1112 24 scarce scarce JJ cord-014516-r59usk02 1112 25 . . . cord-014516-r59usk02 1113 1 This this DT cord-014516-r59usk02 1113 2 study study NN cord-014516-r59usk02 1113 3 was be VBD cord-014516-r59usk02 1113 4 undertaken undertake VBN cord-014516-r59usk02 1113 5 to to TO cord-014516-r59usk02 1113 6 describe describe VB cord-014516-r59usk02 1113 7 blood blood NN cord-014516-r59usk02 1113 8 pressure pressure NN cord-014516-r59usk02 1113 9 measurement measurement NN cord-014516-r59usk02 1113 10 , , , cord-014516-r59usk02 1113 11 physical physical JJ cord-014516-r59usk02 1113 12 examination examination NN cord-014516-r59usk02 1113 13 ( ( -LRB- cord-014516-r59usk02 1113 14 PE PE NNP cord-014516-r59usk02 1113 15 ) ) -RRB- cord-014516-r59usk02 1113 16 abnormalities abnormality NNS cord-014516-r59usk02 1113 17 and and CC cord-014516-r59usk02 1113 18 routine routine JJ cord-014516-r59usk02 1113 19 laboratory laboratory NN cord-014516-r59usk02 1113 20 test test NN cord-014516-r59usk02 1113 21 results result NNS cord-014516-r59usk02 1113 22 in in IN cord-014516-r59usk02 1113 23 senior senior JJ cord-014516-r59usk02 1113 24 and and CC cord-014516-r59usk02 1113 25 geriatric geriatric JJ cord-014516-r59usk02 1113 26 dogs dog NNS cord-014516-r59usk02 1113 27 that that WDT cord-014516-r59usk02 1113 28 were be VBD cord-014516-r59usk02 1113 29 apparently apparently RB cord-014516-r59usk02 1113 30 healthy healthy JJ cord-014516-r59usk02 1113 31 for for IN cord-014516-r59usk02 1113 32 the the DT cord-014516-r59usk02 1113 33 owner owner NN cord-014516-r59usk02 1113 34 . . . cord-014516-r59usk02 1114 1 Because because IN cord-014516-r59usk02 1114 2 life life NN cord-014516-r59usk02 1114 3 expectancy expectancy NN cord-014516-r59usk02 1114 4 in in IN cord-014516-r59usk02 1114 5 dogs dog NNS cord-014516-r59usk02 1114 6 is be VBZ cord-014516-r59usk02 1114 7 related relate VBN cord-014516-r59usk02 1114 8 to to IN cord-014516-r59usk02 1114 9 body body NN cord-014516-r59usk02 1114 10 size size NN cord-014516-r59usk02 1114 11 , , , cord-014516-r59usk02 1114 12 the the DT cord-014516-r59usk02 1114 13 inclusion inclusion NN cord-014516-r59usk02 1114 14 of of IN cord-014516-r59usk02 1114 15 100 100 CD cord-014516-r59usk02 1114 16 dogs dog NNS cord-014516-r59usk02 1114 17 was be VBD cord-014516-r59usk02 1114 18 based base VBN cord-014516-r59usk02 1114 19 on on IN cord-014516-r59usk02 1114 20 a a DT cord-014516-r59usk02 1114 21 human human JJ cord-014516-r59usk02 1114 22 / / SYM cord-014516-r59usk02 1114 23 pet pet JJ cord-014516-r59usk02 1114 24 analogy analogy NN cord-014516-r59usk02 1114 25 chart chart NN cord-014516-r59usk02 1114 26 to to TO cord-014516-r59usk02 1114 27 determine determine VB cord-014516-r59usk02 1114 28 whether whether IN cord-014516-r59usk02 1114 29 a a DT cord-014516-r59usk02 1114 30 dog dog NN cord-014516-r59usk02 1114 31 was be VBD cord-014516-r59usk02 1114 32 senior senior JJ cord-014516-r59usk02 1114 33 ( ( -LRB- cord-014516-r59usk02 1114 34 n n NN cord-014516-r59usk02 1114 35 = = SYM cord-014516-r59usk02 1114 36 41 41 CD cord-014516-r59usk02 1114 37 ) ) -RRB- cord-014516-r59usk02 1114 38 or or CC cord-014516-r59usk02 1114 39 geriatric geriatric JJ cord-014516-r59usk02 1114 40 ( ( -LRB- cord-014516-r59usk02 1114 41 n n NN cord-014516-r59usk02 1114 42 = = SYM cord-014516-r59usk02 1114 43 59 59 CD cord-014516-r59usk02 1114 44 ) ) -RRB- cord-014516-r59usk02 1114 45 . . . cord-014516-r59usk02 1115 1 To to TO cord-014516-r59usk02 1115 2 verify verify VB cord-014516-r59usk02 1115 3 health health NN cord-014516-r59usk02 1115 4 status status NN cord-014516-r59usk02 1115 5 , , , cord-014516-r59usk02 1115 6 owners owner NNS cord-014516-r59usk02 1115 7 were be VBD cord-014516-r59usk02 1115 8 asked ask VBN cord-014516-r59usk02 1115 9 to to TO cord-014516-r59usk02 1115 10 complete complete VB cord-014516-r59usk02 1115 11 an an DT cord-014516-r59usk02 1115 12 extensive extensive JJ cord-014516-r59usk02 1115 13 questionnaire questionnaire NN cord-014516-r59usk02 1115 14 . . . cord-014516-r59usk02 1116 1 Systolic systolic JJ cord-014516-r59usk02 1116 2 blood blood NN cord-014516-r59usk02 1116 3 pressure pressure NN cord-014516-r59usk02 1116 4 ( ( -LRB- cord-014516-r59usk02 1116 5 SBP SBP NNP cord-014516-r59usk02 1116 6 ) ) -RRB- cord-014516-r59usk02 1116 7 was be VBD cord-014516-r59usk02 1116 8 measured measure VBN cord-014516-r59usk02 1116 9 using use VBG cord-014516-r59usk02 1116 10 the the DT cord-014516-r59usk02 1116 11 Doppler Doppler NNP cord-014516-r59usk02 1116 12 technique technique NN cord-014516-r59usk02 1116 13 according accord VBG cord-014516-r59usk02 1116 14 to to IN cord-014516-r59usk02 1116 15 the the DT cord-014516-r59usk02 1116 16 ACVIM ACVIM NNP cord-014516-r59usk02 1116 17 guidelines guideline NNS cord-014516-r59usk02 1116 18 . . . cord-014516-r59usk02 1117 1 Subsequently subsequently RB cord-014516-r59usk02 1117 2 a a DT cord-014516-r59usk02 1117 3 thorough thorough JJ cord-014516-r59usk02 1117 4 PE pe NN cord-014516-r59usk02 1117 5 was be VBD cord-014516-r59usk02 1117 6 performed perform VBN cord-014516-r59usk02 1117 7 , , , cord-014516-r59usk02 1117 8 including include VBG cord-014516-r59usk02 1117 9 body body NN cord-014516-r59usk02 1117 10 and and CC cord-014516-r59usk02 1117 11 muscle muscle NN cord-014516-r59usk02 1117 12 condition condition NN cord-014516-r59usk02 1117 13 scoring scoring NN cord-014516-r59usk02 1117 14 , , , cord-014516-r59usk02 1117 15 orthopedic orthopedic NN cord-014516-r59usk02 1117 16 examination examination NN cord-014516-r59usk02 1117 17 , , , cord-014516-r59usk02 1117 18 neurologic neurologic JJ cord-014516-r59usk02 1117 19 evaluation evaluation NN cord-014516-r59usk02 1117 20 , , , cord-014516-r59usk02 1117 21 indirect indirect JJ cord-014516-r59usk02 1117 22 fundoscopy fundoscopy NN cord-014516-r59usk02 1117 23 and and CC cord-014516-r59usk02 1117 24 bilateral bilateral JJ cord-014516-r59usk02 1117 25 Schirmer Schirmer NNP cord-014516-r59usk02 1117 26 tear tear NN cord-014516-r59usk02 1117 27 test test NN cord-014516-r59usk02 1117 28 . . . cord-014516-r59usk02 1118 1 Complete complete JJ cord-014516-r59usk02 1118 2 blood blood NN cord-014516-r59usk02 1118 3 count count NN cord-014516-r59usk02 1118 4 , , , cord-014516-r59usk02 1118 5 serum serum NN cord-014516-r59usk02 1118 6 biochemistry biochemistry NN cord-014516-r59usk02 1118 7 and and CC cord-014516-r59usk02 1118 8 urinalysis urinalysis NN cord-014516-r59usk02 1118 9 ( ( -LRB- cord-014516-r59usk02 1118 10 including include VBG cord-014516-r59usk02 1118 11 urinary urinary JJ cord-014516-r59usk02 1118 12 sediment sediment NN cord-014516-r59usk02 1118 13 , , , cord-014516-r59usk02 1118 14 urinary urinary JJ cord-014516-r59usk02 1118 15 protein protein NN cord-014516-r59usk02 1118 16 : : : cord-014516-r59usk02 1118 17 creatinine creatinine NN cord-014516-r59usk02 1118 18 ratio ratio NN cord-014516-r59usk02 1118 19 ( ( -LRB- cord-014516-r59usk02 1118 20 UPC UPC NNP cord-014516-r59usk02 1118 21 ) ) -RRB- cord-014516-r59usk02 1118 22 and and CC cord-014516-r59usk02 1118 23 bacterial bacterial JJ cord-014516-r59usk02 1118 24 culture culture NN cord-014516-r59usk02 1118 25 ) ) -RRB- cord-014516-r59usk02 1118 26 were be VBD cord-014516-r59usk02 1118 27 evaluated evaluate VBN cord-014516-r59usk02 1118 28 . . . cord-014516-r59usk02 1119 1 In in IN cord-014516-r59usk02 1119 2 53 53 CD cord-014516-r59usk02 1119 3 of of IN cord-014516-r59usk02 1119 4 100 100 CD cord-014516-r59usk02 1119 5 dogs dog NNS cord-014516-r59usk02 1119 6 SBP SBP NNP cord-014516-r59usk02 1119 7 exceeded exceed VBD cord-014516-r59usk02 1119 8 160 160 CD cord-014516-r59usk02 1119 9 mmHg mmHg NNS cord-014516-r59usk02 1119 10 , , , cord-014516-r59usk02 1119 11 none none NN cord-014516-r59usk02 1119 12 of of IN cord-014516-r59usk02 1119 13 the the DT cord-014516-r59usk02 1119 14 dogs dog NNS cord-014516-r59usk02 1119 15 had have VBD cord-014516-r59usk02 1119 16 fundoscopic fundoscopic JJ cord-014516-r59usk02 1119 17 lesions lesion NNS cord-014516-r59usk02 1119 18 secondary secondary JJ cord-014516-r59usk02 1119 19 to to IN cord-014516-r59usk02 1119 20 hypertension hypertension NN cord-014516-r59usk02 1119 21 . . . cord-014516-r59usk02 1120 1 Body body NN cord-014516-r59usk02 1120 2 condition condition NN cord-014516-r59usk02 1120 3 score score NN cord-014516-r59usk02 1120 4 was be VBD cord-014516-r59usk02 1120 5 abnormal abnormal JJ cord-014516-r59usk02 1120 6 in in IN cord-014516-r59usk02 1120 7 41 41 CD cord-014516-r59usk02 1120 8 animals animal NNS cord-014516-r59usk02 1120 9 , , , cord-014516-r59usk02 1120 10 39 39 CD cord-014516-r59usk02 1120 11 were be VBD cord-014516-r59usk02 1120 12 overweight overweight JJ cord-014516-r59usk02 1120 13 or or CC cord-014516-r59usk02 1120 14 obese obese JJ cord-014516-r59usk02 1120 15 . . . cord-014516-r59usk02 1121 1 Physical physical JJ cord-014516-r59usk02 1121 2 examination examination NN cord-014516-r59usk02 1121 3 revealed reveal VBD cord-014516-r59usk02 1121 4 a a DT cord-014516-r59usk02 1121 5 heart heart NN cord-014516-r59usk02 1121 6 murmur murmur NN cord-014516-r59usk02 1121 7 in in IN cord-014516-r59usk02 1121 8 22 22 CD cord-014516-r59usk02 1121 9 , , , cord-014516-r59usk02 1121 10 submandibular submandibular JJ cord-014516-r59usk02 1121 11 lymphadenopathy lymphadenopathy NN cord-014516-r59usk02 1121 12 in in IN cord-014516-r59usk02 1121 13 13 13 CD cord-014516-r59usk02 1121 14 , , , cord-014516-r59usk02 1121 15 moderate moderate JJ cord-014516-r59usk02 1121 16 to to IN cord-014516-r59usk02 1121 17 severe severe JJ cord-014516-r59usk02 1121 18 dental dental JJ cord-014516-r59usk02 1121 19 plaque plaque NN cord-014516-r59usk02 1121 20 in in IN cord-014516-r59usk02 1121 21 51 51 CD cord-014516-r59usk02 1121 22 and and CC cord-014516-r59usk02 1121 23 one one CD cord-014516-r59usk02 1121 24 or or CC cord-014516-r59usk02 1121 25 more more JJR cord-014516-r59usk02 1121 26 ( ( -LRB- cord-014516-r59usk02 1121 27 sub)cutaneous sub)cutaneous JJ cord-014516-r59usk02 1121 28 masses masse NNS cord-014516-r59usk02 1121 29 in in IN cord-014516-r59usk02 1121 30 56 56 CD cord-014516-r59usk02 1121 31 dogs dog NNS cord-014516-r59usk02 1121 32 . . . cord-014516-r59usk02 1122 1 Twenty twenty CD cord-014516-r59usk02 1122 2 - - HYPH cord-014516-r59usk02 1122 3 three three CD cord-014516-r59usk02 1122 4 dogs dog NNS cord-014516-r59usk02 1122 5 were be VBD cord-014516-r59usk02 1122 6 leukopenic leukopenic JJ cord-014516-r59usk02 1122 7 , , , cord-014516-r59usk02 1122 8 29 29 CD cord-014516-r59usk02 1122 9 had have VBD cord-014516-r59usk02 1122 10 a a DT cord-014516-r59usk02 1122 11 decreased decrease VBN cord-014516-r59usk02 1122 12 phosphorus phosphorus NN cord-014516-r59usk02 1122 13 , , , cord-014516-r59usk02 1122 14 32 32 CD cord-014516-r59usk02 1122 15 an an DT cord-014516-r59usk02 1122 16 increased increase VBN cord-014516-r59usk02 1122 17 serum serum NN cord-014516-r59usk02 1122 18 creatinine creatinine NN cord-014516-r59usk02 1122 19 and and CC cord-014516-r59usk02 1122 20 one one CD cord-014516-r59usk02 1122 21 dog dog NN cord-014516-r59usk02 1122 22 a a DT cord-014516-r59usk02 1122 23 decreased decrease VBD cord-014516-r59usk02 1122 24 total total JJ cord-014516-r59usk02 1122 25 thyroxine thyroxine NN cord-014516-r59usk02 1122 26 ( ( -LRB- cord-014516-r59usk02 1122 27 with with IN cord-014516-r59usk02 1122 28 concurrent concurrent JJ cord-014516-r59usk02 1122 29 increased increase VBN cord-014516-r59usk02 1122 30 thyroid thyroid JJ cord-014516-r59usk02 1122 31 stimulating stimulate VBG cord-014516-r59usk02 1122 32 hormone hormone NN cord-014516-r59usk02 1122 33 ) ) -RRB- cord-014516-r59usk02 1122 34 . . . cord-014516-r59usk02 1123 1 Crystalluria Crystalluria NNP cord-014516-r59usk02 1123 2 was be VBD cord-014516-r59usk02 1123 3 commonly commonly RB cord-014516-r59usk02 1123 4 detected detect VBN cord-014516-r59usk02 1123 5 ( ( -LRB- cord-014516-r59usk02 1123 6 62/96 62/96 CD cord-014516-r59usk02 1123 7 ) ) -RRB- cord-014516-r59usk02 1123 8 and and CC cord-014516-r59usk02 1123 9 mostly mostly RB cord-014516-r59usk02 1123 10 due due JJ cord-014516-r59usk02 1123 11 to to IN cord-014516-r59usk02 1123 12 low low JJ cord-014516-r59usk02 1123 13 numbers number NNS cord-014516-r59usk02 1123 14 ( ( -LRB- cord-014516-r59usk02 1123 15 < < NNP cord-014516-r59usk02 1123 16 1 1 CD cord-014516-r59usk02 1123 17 / / SYM cord-014516-r59usk02 1123 18 high high JJ cord-014516-r59usk02 1123 19 power power NN cord-014516-r59usk02 1123 20 field field NN cord-014516-r59usk02 1123 21 ) ) -RRB- cord-014516-r59usk02 1123 22 of of IN cord-014516-r59usk02 1123 23 amorphous amorphous JJ cord-014516-r59usk02 1123 24 crystals crystal NNS cord-014516-r59usk02 1123 25 ( ( -LRB- cord-014516-r59usk02 1123 26 82 82 CD cord-014516-r59usk02 1123 27 % % NN cord-014516-r59usk02 1123 28 ) ) -RRB- cord-014516-r59usk02 1123 29 . . . cord-014516-r59usk02 1124 1 Struvite Struvite NNP cord-014516-r59usk02 1124 2 crystals crystal NNS cord-014516-r59usk02 1124 3 were be VBD cord-014516-r59usk02 1124 4 present present JJ cord-014516-r59usk02 1124 5 in in IN cord-014516-r59usk02 1124 6 18 18 CD cord-014516-r59usk02 1124 7 % % NN cord-014516-r59usk02 1124 8 of of IN cord-014516-r59usk02 1124 9 the the DT cord-014516-r59usk02 1124 10 crystalluric crystalluric JJ cord-014516-r59usk02 1124 11 dogs dog NNS cord-014516-r59usk02 1124 12 . . . cord-014516-r59usk02 1125 1 Overt overt JJ cord-014516-r59usk02 1125 2 and and CC cord-014516-r59usk02 1125 3 borderline borderline JJ cord-014516-r59usk02 1125 4 proteinuria proteinuria NN cord-014516-r59usk02 1125 5 were be VBD cord-014516-r59usk02 1125 6 detected detect VBN cord-014516-r59usk02 1125 7 in in IN cord-014516-r59usk02 1125 8 13 13 CD cord-014516-r59usk02 1125 9 and and CC cord-014516-r59usk02 1125 10 18 18 CD cord-014516-r59usk02 1125 11 of of IN cord-014516-r59usk02 1125 12 98 98 CD cord-014516-r59usk02 1125 13 dogs dog NNS cord-014516-r59usk02 1125 14 , , , cord-014516-r59usk02 1125 15 respectively respectively RB cord-014516-r59usk02 1125 16 . . . cord-014516-r59usk02 1126 1 Four four CD cord-014516-r59usk02 1126 2 dogs dog NNS cord-014516-r59usk02 1126 3 had have VBD cord-014516-r59usk02 1126 4 a a DT cord-014516-r59usk02 1126 5 positive positive JJ cord-014516-r59usk02 1126 6 urinary urinary JJ cord-014516-r59usk02 1126 7 culture culture NN cord-014516-r59usk02 1126 8 . . . cord-014516-r59usk02 1127 1 SBP SBP NNP cord-014516-r59usk02 1127 2 was be VBD cord-014516-r59usk02 1127 3 not not RB cord-014516-r59usk02 1127 4 significantly significantly RB cord-014516-r59usk02 1127 5 different different JJ cord-014516-r59usk02 1127 6 between between IN cord-014516-r59usk02 1127 7 the the DT cord-014516-r59usk02 1127 8 senior senior JJ cord-014516-r59usk02 1127 9 and and CC cord-014516-r59usk02 1127 10 geriatric geriatric JJ cord-014516-r59usk02 1127 11 group group NN cord-014516-r59usk02 1127 12 . . . cord-014516-r59usk02 1128 1 There there EX cord-014516-r59usk02 1128 2 was be VBD cord-014516-r59usk02 1128 3 no no DT cord-014516-r59usk02 1128 4 significant significant JJ cord-014516-r59usk02 1128 5 effect effect NN cord-014516-r59usk02 1128 6 of of IN cord-014516-r59usk02 1128 7 obesity obesity NN cord-014516-r59usk02 1128 8 or or CC cord-014516-r59usk02 1128 9 gender gender NN cord-014516-r59usk02 1128 10 on on IN cord-014516-r59usk02 1128 11 SBP SBP NNP cord-014516-r59usk02 1128 12 . . . cord-014516-r59usk02 1129 1 The the DT cord-014516-r59usk02 1129 2 platelet platelet NN cord-014516-r59usk02 1129 3 count count NN cord-014516-r59usk02 1129 4 ( ( -LRB- cord-014516-r59usk02 1129 5 p p NN cord-014516-r59usk02 1129 6 = = SYM cord-014516-r59usk02 1129 7 0.014 0.014 CD cord-014516-r59usk02 1129 8 ) ) -RRB- cord-014516-r59usk02 1129 9 , , , cord-014516-r59usk02 1129 10 total total JJ cord-014516-r59usk02 1129 11 thyroxine thyroxine JJ cord-014516-r59usk02 1129 12 concentration concentration NN cord-014516-r59usk02 1129 13 ( ( -LRB- cord-014516-r59usk02 1129 14 p p NN cord-014516-r59usk02 1129 15 = = SYM cord-014516-r59usk02 1129 16 0.008 0.008 CD cord-014516-r59usk02 1129 17 ) ) -RRB- cord-014516-r59usk02 1129 18 and and CC cord-014516-r59usk02 1129 19 the the DT cord-014516-r59usk02 1129 20 frequency frequency NN cord-014516-r59usk02 1129 21 of of IN cord-014516-r59usk02 1129 22 orthopedic orthopedic NN cord-014516-r59usk02 1129 23 problems problem NNS cord-014516-r59usk02 1129 24 ( ( -LRB- cord-014516-r59usk02 1129 25 p p NN cord-014516-r59usk02 1129 26 = = SYM cord-014516-r59usk02 1129 27 0.007 0.007 CD cord-014516-r59usk02 1129 28 ) ) -RRB- cord-014516-r59usk02 1129 29 and and CC cord-014516-r59usk02 1129 30 cutaneous cutaneous JJ cord-014516-r59usk02 1129 31 masses masse NNS cord-014516-r59usk02 1129 32 ( ( -LRB- cord-014516-r59usk02 1129 33 p p NN cord-014516-r59usk02 1129 34 = = SYM cord-014516-r59usk02 1129 35 0.002 0.002 CD cord-014516-r59usk02 1129 36 ) ) -RRB- cord-014516-r59usk02 1129 37 were be VBD cord-014516-r59usk02 1129 38 significantly significantly RB cord-014516-r59usk02 1129 39 higher high JJR cord-014516-r59usk02 1129 40 in in IN cord-014516-r59usk02 1129 41 the the DT cord-014516-r59usk02 1129 42 geriatric geriatric NN cord-014516-r59usk02 1129 43 compared compare VBN cord-014516-r59usk02 1129 44 to to IN cord-014516-r59usk02 1129 45 the the DT cord-014516-r59usk02 1129 46 senior senior JJ cord-014516-r59usk02 1129 47 dogs dog NNS cord-014516-r59usk02 1129 48 . . . cord-014516-r59usk02 1130 1 Hematocrit hematocrit NN cord-014516-r59usk02 1130 2 ( ( -LRB- cord-014516-r59usk02 1130 3 p p NN cord-014516-r59usk02 1130 4 = = SYM cord-014516-r59usk02 1130 5 0.007 0.007 CD cord-014516-r59usk02 1130 6 ) ) -RRB- cord-014516-r59usk02 1130 7 and and CC cord-014516-r59usk02 1130 8 body body NN cord-014516-r59usk02 1130 9 temperature temperature NN cord-014516-r59usk02 1130 10 ( ( -LRB- cord-014516-r59usk02 1130 11 p p NN cord-014516-r59usk02 1130 12 = = SYM cord-014516-r59usk02 1130 13 0.044 0.044 CD cord-014516-r59usk02 1130 14 ) ) -RRB- cord-014516-r59usk02 1130 15 were be VBD cord-014516-r59usk02 1130 16 significantly significantly RB cord-014516-r59usk02 1130 17 lower low JJR cord-014516-r59usk02 1130 18 in in IN cord-014516-r59usk02 1130 19 the the DT cord-014516-r59usk02 1130 20 geriatric geriatric JJ cord-014516-r59usk02 1130 21 group group NN cord-014516-r59usk02 1130 22 . . . cord-014516-r59usk02 1131 1 These these DT cord-014516-r59usk02 1131 2 findings finding NNS cord-014516-r59usk02 1131 3 indicate indicate VBP cord-014516-r59usk02 1131 4 that that IN cord-014516-r59usk02 1131 5 physical physical JJ cord-014516-r59usk02 1131 6 and and CC cord-014516-r59usk02 1131 7 laboratory laboratory NN cord-014516-r59usk02 1131 8 abnormalities abnormality NNS cord-014516-r59usk02 1131 9 are be VBP cord-014516-r59usk02 1131 10 common common JJ cord-014516-r59usk02 1131 11 in in IN cord-014516-r59usk02 1131 12 apparently apparently RB cord-014516-r59usk02 1131 13 healthy healthy JJ cord-014516-r59usk02 1131 14 senior senior JJ cord-014516-r59usk02 1131 15 and and CC cord-014516-r59usk02 1131 16 geriatric geriatric JJ cord-014516-r59usk02 1131 17 dogs dog NNS cord-014516-r59usk02 1131 18 . . . cord-014516-r59usk02 1132 1 This this DT cord-014516-r59usk02 1132 2 underlines underline VBZ cord-014516-r59usk02 1132 3 the the DT cord-014516-r59usk02 1132 4 necessity necessity NN cord-014516-r59usk02 1132 5 for for IN cord-014516-r59usk02 1132 6 regular regular JJ cord-014516-r59usk02 1132 7 health health NN cord-014516-r59usk02 1132 8 screening screening NN cord-014516-r59usk02 1132 9 in in IN cord-014516-r59usk02 1132 10 elderly elderly JJ cord-014516-r59usk02 1132 11 dogs dog NNS cord-014516-r59usk02 1132 12 and and CC cord-014516-r59usk02 1132 13 the the DT cord-014516-r59usk02 1132 14 urgent urgent JJ cord-014516-r59usk02 1132 15 need need NN cord-014516-r59usk02 1132 16 for for IN cord-014516-r59usk02 1132 17 reliable reliable JJ cord-014516-r59usk02 1132 18 and and CC cord-014516-r59usk02 1132 19 maybe maybe RB cord-014516-r59usk02 1132 20 age age NN cord-014516-r59usk02 1132 21 specific specific JJ cord-014516-r59usk02 1132 22 reference reference NN cord-014516-r59usk02 1132 23 intervals interval NNS cord-014516-r59usk02 1132 24 in in IN cord-014516-r59usk02 1132 25 veterinary veterinary JJ cord-014516-r59usk02 1132 26 medicine medicine NN cord-014516-r59usk02 1132 27 . . . cord-014516-r59usk02 1133 1 The the DT cord-014516-r59usk02 1133 2 cost cost NN cord-014516-r59usk02 1133 3 of of IN cord-014516-r59usk02 1133 4 examinations examination NNS cord-014516-r59usk02 1133 5 reported report VBN cord-014516-r59usk02 1133 6 in in IN cord-014516-r59usk02 1133 7 this this DT cord-014516-r59usk02 1133 8 study study NN cord-014516-r59usk02 1133 9 were be VBD cord-014516-r59usk02 1133 10 covered cover VBN cord-014516-r59usk02 1133 11 by by IN cord-014516-r59usk02 1133 12 Hill Hill NNP cord-014516-r59usk02 1133 13 's 's POS cord-014516-r59usk02 1133 14 Pet Pet NNP cord-014516-r59usk02 1133 15 Nutrition Nutrition NNP cord-014516-r59usk02 1133 16 Belgium Belgium NNP cord-014516-r59usk02 1133 17 . . . cord-014516-r59usk02 1134 1 Systemic systemic JJ cord-014516-r59usk02 1134 2 Lupus Lupus NNP cord-014516-r59usk02 1134 3 Erythematosus Erythematosus NNP cord-014516-r59usk02 1134 4 , , , cord-014516-r59usk02 1134 5 SLE SLE NNP cord-014516-r59usk02 1134 6 , , , cord-014516-r59usk02 1134 7 is be VBZ cord-014516-r59usk02 1134 8 a a DT cord-014516-r59usk02 1134 9 chronic chronic JJ cord-014516-r59usk02 1134 10 autoimmune autoimmune JJ cord-014516-r59usk02 1134 11 disorder disorder NN cord-014516-r59usk02 1134 12 with with IN cord-014516-r59usk02 1134 13 varying vary VBG cord-014516-r59usk02 1134 14 clinical clinical JJ cord-014516-r59usk02 1134 15 manifestations manifestation NNS cord-014516-r59usk02 1134 16 and and CC cord-014516-r59usk02 1134 17 diagnosis diagnosis NN cord-014516-r59usk02 1134 18 is be VBZ cord-014516-r59usk02 1134 19 based base VBN cord-014516-r59usk02 1134 20 on on IN cord-014516-r59usk02 1134 21 both both DT cord-014516-r59usk02 1134 22 clinical clinical JJ cord-014516-r59usk02 1134 23 signs sign NNS cord-014516-r59usk02 1134 24 and and CC cord-014516-r59usk02 1134 25 laboratory laboratory NN cord-014516-r59usk02 1134 26 findings finding NNS cord-014516-r59usk02 1134 27 . . . cord-014516-r59usk02 1135 1 Other other JJ cord-014516-r59usk02 1135 2 systemic systemic JJ cord-014516-r59usk02 1135 3 rheumatic rheumatic JJ cord-014516-r59usk02 1135 4 diseases disease NNS cord-014516-r59usk02 1135 5 , , , cord-014516-r59usk02 1135 6 referred refer VBD cord-014516-r59usk02 1135 7 to to IN cord-014516-r59usk02 1135 8 as as IN cord-014516-r59usk02 1135 9 SLE sle NN cord-014516-r59usk02 1135 10 - - HYPH cord-014516-r59usk02 1135 11 related relate VBN cord-014516-r59usk02 1135 12 diseases disease NNS cord-014516-r59usk02 1135 13 or or CC cord-014516-r59usk02 1135 14 immune immune NN cord-014516-r59usk02 1135 15 - - HYPH cord-014516-r59usk02 1135 16 mediated mediate VBN cord-014516-r59usk02 1135 17 rheumatic rheumatic JJ cord-014516-r59usk02 1135 18 disease disease NN cord-014516-r59usk02 1135 19 ( ( -LRB- cord-014516-r59usk02 1135 20 IMRD IMRD NNP cord-014516-r59usk02 1135 21 ) ) -RRB- cord-014516-r59usk02 1135 22 , , , cord-014516-r59usk02 1135 23 are be VBP cord-014516-r59usk02 1135 24 also also RB cord-014516-r59usk02 1135 25 described describe VBN cord-014516-r59usk02 1135 26 . . . cord-014516-r59usk02 1136 1 The the DT cord-014516-r59usk02 1136 2 most most RBS cord-014516-r59usk02 1136 3 common common JJ cord-014516-r59usk02 1136 4 clinical clinical JJ cord-014516-r59usk02 1136 5 signs sign NNS cord-014516-r59usk02 1136 6 in in IN cord-014516-r59usk02 1136 7 dogs dog NNS cord-014516-r59usk02 1136 8 are be VBP cord-014516-r59usk02 1136 9 stiffness stiffness NN cord-014516-r59usk02 1136 10 and and CC cord-014516-r59usk02 1136 11 pain pain NN cord-014516-r59usk02 1136 12 from from IN cord-014516-r59usk02 1136 13 varying vary VBG cord-014516-r59usk02 1136 14 joints joint NNS cord-014516-r59usk02 1136 15 . . . cord-014516-r59usk02 1137 1 One one CD cord-014516-r59usk02 1137 2 hallmark hallmark NN cord-014516-r59usk02 1137 3 of of IN cord-014516-r59usk02 1137 4 SLE SLE NNP cord-014516-r59usk02 1137 5 and and CC cord-014516-r59usk02 1137 6 SLE sle NN cord-014516-r59usk02 1137 7 - - HYPH cord-014516-r59usk02 1137 8 related relate VBN cord-014516-r59usk02 1137 9 diseases disease NNS cord-014516-r59usk02 1137 10 in in IN cord-014516-r59usk02 1137 11 both both DT cord-014516-r59usk02 1137 12 dogs dog NNS cord-014516-r59usk02 1137 13 and and CC cord-014516-r59usk02 1137 14 humans human NNS cord-014516-r59usk02 1137 15 is be VBZ cord-014516-r59usk02 1137 16 high high JJ cord-014516-r59usk02 1137 17 titres titre NNS cord-014516-r59usk02 1137 18 of of IN cord-014516-r59usk02 1137 19 circulating circulate VBG cord-014516-r59usk02 1137 20 antinuclear antinuclear JJ cord-014516-r59usk02 1137 21 antibodies antibody NNS cord-014516-r59usk02 1137 22 ( ( -LRB- cord-014516-r59usk02 1137 23 ANA ANA NNP cord-014516-r59usk02 1137 24 ) ) -RRB- cord-014516-r59usk02 1137 25 , , , cord-014516-r59usk02 1137 26 which which WDT cord-014516-r59usk02 1137 27 can can MD cord-014516-r59usk02 1137 28 be be VB cord-014516-r59usk02 1137 29 demonstrated demonstrate VBN cord-014516-r59usk02 1137 30 by by IN cord-014516-r59usk02 1137 31 the the DT cord-014516-r59usk02 1137 32 indirect indirect JJ cord-014516-r59usk02 1137 33 immunofluorescence immunofluorescence NN cord-014516-r59usk02 1137 34 ( ( -LRB- cord-014516-r59usk02 1137 35 IIF IIF NNP cord-014516-r59usk02 1137 36 ) ) -RRB- cord-014516-r59usk02 1137 37 ANA ANA NNP cord-014516-r59usk02 1137 38 test test NN cord-014516-r59usk02 1137 39 . . . cord-014516-r59usk02 1138 1 Earlier early JJR cord-014516-r59usk02 1138 2 studies study NNS cord-014516-r59usk02 1138 3 have have VBP cord-014516-r59usk02 1138 4 shown show VBN cord-014516-r59usk02 1138 5 that that IN cord-014516-r59usk02 1138 6 canine canine JJ cord-014516-r59usk02 1138 7 IIF IIF NNP cord-014516-r59usk02 1138 8 ANA ANA NNP cord-014516-r59usk02 1138 9 positive positive JJ cord-014516-r59usk02 1138 10 samples sample NNS cord-014516-r59usk02 1138 11 may may MD cord-014516-r59usk02 1138 12 be be VB cord-014516-r59usk02 1138 13 divided divide VBN cord-014516-r59usk02 1138 14 into into IN cord-014516-r59usk02 1138 15 two two CD cord-014516-r59usk02 1138 16 main main JJ cord-014516-r59usk02 1138 17 subgroups subgroup NNS cord-014516-r59usk02 1138 18 : : : cord-014516-r59usk02 1138 19 homogenous homogenous JJ cord-014516-r59usk02 1138 20 ( ( -LRB- cord-014516-r59usk02 1138 21 ANA ANA NNP cord-014516-r59usk02 1138 22 H H NNP cord-014516-r59usk02 1138 23 ) ) -RRB- cord-014516-r59usk02 1138 24 and and CC cord-014516-r59usk02 1138 25 speckled speckle VBN cord-014516-r59usk02 1138 26 ( ( -LRB- cord-014516-r59usk02 1138 27 ANA ANA NNP cord-014516-r59usk02 1138 28 S S NNP cord-014516-r59usk02 1138 29 ) ) -RRB- cord-014516-r59usk02 1139 1 IIF IIF NNP cord-014516-r59usk02 1139 2 ANA ANA NNP cord-014516-r59usk02 1139 3 fluorescence fluorescence NN cord-014516-r59usk02 1139 4 pattern pattern NN cord-014516-r59usk02 1139 5 . . . cord-014516-r59usk02 1140 1 In in IN cord-014516-r59usk02 1140 2 humans human NNS cord-014516-r59usk02 1140 3 , , , cord-014516-r59usk02 1140 4 further further JJ cord-014516-r59usk02 1140 5 determination determination NN cord-014516-r59usk02 1140 6 of of IN cord-014516-r59usk02 1140 7 the the DT cord-014516-r59usk02 1140 8 specificity specificity NN cord-014516-r59usk02 1140 9 of of IN cord-014516-r59usk02 1140 10 ANA ANA NNP cord-014516-r59usk02 1140 11 positive positive JJ cord-014516-r59usk02 1140 12 sera sera NNP cord-014516-r59usk02 1140 13 is be VBZ cord-014516-r59usk02 1140 14 frequently frequently RB cord-014516-r59usk02 1140 15 employed employ VBN cord-014516-r59usk02 1140 16 to to TO cord-014516-r59usk02 1140 17 characterize characterize VB cord-014516-r59usk02 1140 18 the the DT cord-014516-r59usk02 1140 19 ANA ANA NNP cord-014516-r59usk02 1140 20 reactivity reactivity NN cord-014516-r59usk02 1140 21 . . . cord-014516-r59usk02 1141 1 Some some DT cord-014516-r59usk02 1141 2 of of IN cord-014516-r59usk02 1141 3 these these DT cord-014516-r59usk02 1141 4 ANA ANA NNP cord-014516-r59usk02 1141 5 specificities specificity NNS cord-014516-r59usk02 1141 6 have have VBP cord-014516-r59usk02 1141 7 been be VBN cord-014516-r59usk02 1141 8 demonstrated demonstrate VBN cord-014516-r59usk02 1141 9 in in IN cord-014516-r59usk02 1141 10 man man NN cord-014516-r59usk02 1141 11 to to TO cord-014516-r59usk02 1141 12 strongly strongly RB cord-014516-r59usk02 1141 13 associate associate VB cord-014516-r59usk02 1141 14 with with IN cord-014516-r59usk02 1141 15 different different JJ cord-014516-r59usk02 1141 16 systemic systemic JJ cord-014516-r59usk02 1141 17 autoimmune autoimmune JJ cord-014516-r59usk02 1141 18 diseases disease NNS cord-014516-r59usk02 1141 19 and and CC cord-014516-r59usk02 1141 20 also also RB cord-014516-r59usk02 1141 21 with with IN cord-014516-r59usk02 1141 22 different different JJ cord-014516-r59usk02 1141 23 IIF IIF NNP cord-014516-r59usk02 1141 24 ANA ANA NNP cord-014516-r59usk02 1141 25 staining staining NN cord-014516-r59usk02 1141 26 patterns pattern NNS cord-014516-r59usk02 1141 27 . . . cord-014516-r59usk02 1142 1 Presence presence NN cord-014516-r59usk02 1142 2 and and CC cord-014516-r59usk02 1142 3 character character NN cord-014516-r59usk02 1142 4 of of IN cord-014516-r59usk02 1142 5 antinuclear antinuclear JJ cord-014516-r59usk02 1142 6 antibodies antibody NNS cord-014516-r59usk02 1142 7 in in IN cord-014516-r59usk02 1142 8 canine canine JJ cord-014516-r59usk02 1142 9 SLE sle NN cord-014516-r59usk02 1142 10 - - HYPH cord-014516-r59usk02 1142 11 related relate VBN cord-014516-r59usk02 1142 12 diseases disease NNS cord-014516-r59usk02 1142 13 are be VBP cord-014516-r59usk02 1142 14 not not RB cord-014516-r59usk02 1142 15 well well RB cord-014516-r59usk02 1142 16 described describe VBN cord-014516-r59usk02 1142 17 . . . cord-014516-r59usk02 1143 1 The the DT cord-014516-r59usk02 1143 2 aim aim NN cord-014516-r59usk02 1143 3 of of IN cord-014516-r59usk02 1143 4 this this DT cord-014516-r59usk02 1143 5 work work NN cord-014516-r59usk02 1143 6 was be VBD cord-014516-r59usk02 1143 7 to to TO cord-014516-r59usk02 1143 8 further further RB cord-014516-r59usk02 1143 9 characterize characterize VB cord-014516-r59usk02 1143 10 the the DT cord-014516-r59usk02 1143 11 ANA ANA NNP cord-014516-r59usk02 1143 12 specificity specificity NN cord-014516-r59usk02 1143 13 in in IN cord-014516-r59usk02 1143 14 dogs dog NNS cord-014516-r59usk02 1143 15 with with IN cord-014516-r59usk02 1143 16 SLE sle NN cord-014516-r59usk02 1143 17 - - HYPH cord-014516-r59usk02 1143 18 related relate VBN cord-014516-r59usk02 1143 19 disease disease NN cord-014516-r59usk02 1143 20 / / SYM cord-014516-r59usk02 1143 21 IMRD IMRD NNP cord-014516-r59usk02 1143 22 . . . cord-014516-r59usk02 1144 1 Sera Sera NNP cord-014516-r59usk02 1144 2 from from IN cord-014516-r59usk02 1144 3 208 208 CD cord-014516-r59usk02 1144 4 ANApositive anapositive JJ cord-014516-r59usk02 1144 5 dogs dog NNS cord-014516-r59usk02 1144 6 , , , cord-014516-r59usk02 1144 7 including include VBG cord-014516-r59usk02 1144 8 61 61 CD cord-014516-r59usk02 1144 9 different different JJ cord-014516-r59usk02 1144 10 breeds breed NNS cord-014516-r59usk02 1144 11 , , , cord-014516-r59usk02 1144 12 were be VBD cord-014516-r59usk02 1144 13 analyzed analyze VBN cord-014516-r59usk02 1144 14 with with IN cord-014516-r59usk02 1144 15 ELISA ELISA NNP cord-014516-r59usk02 1144 16 and and CC cord-014516-r59usk02 1144 17 line line NN cord-014516-r59usk02 1144 18 blot blot NN cord-014516-r59usk02 1144 19 techniques technique NNS cord-014516-r59usk02 1144 20 ( ( -LRB- cord-014516-r59usk02 1144 21 ELISA ELISA NNP cord-014516-r59usk02 1144 22 and and CC cord-014516-r59usk02 1144 23 EUROLINE EUROLINE NNP cord-014516-r59usk02 1144 24 ANA ANA NNP cord-014516-r59usk02 1144 25 Profile Profile NNP cord-014516-r59usk02 1144 26 , , , cord-014516-r59usk02 1144 27 EUROIMMUN EUROIMMUN NNP cord-014516-r59usk02 1144 28 , , , cord-014516-r59usk02 1144 29 Germany Germany NNP cord-014516-r59usk02 1144 30 ) ) -RRB- cord-014516-r59usk02 1144 31 . . . cord-014516-r59usk02 1145 1 The the DT cord-014516-r59usk02 1145 2 five five CD cord-014516-r59usk02 1145 3 most most RBS cord-014516-r59usk02 1145 4 prevalent prevalent JJ cord-014516-r59usk02 1145 5 breeds breed NNS cord-014516-r59usk02 1145 6 were be VBD cord-014516-r59usk02 1145 7 German german JJ cord-014516-r59usk02 1145 8 shepherd shepherd JJ cord-014516-r59usk02 1145 9 dog dog NN cord-014516-r59usk02 1145 10 , , , cord-014516-r59usk02 1145 11 Nova Nova NNP cord-014516-r59usk02 1145 12 Scotia Scotia NNP cord-014516-r59usk02 1145 13 duck duck NN cord-014516-r59usk02 1145 14 tolling tolling NN cord-014516-r59usk02 1145 15 retriever retriever NN cord-014516-r59usk02 1145 16 , , , cord-014516-r59usk02 1145 17 cocker cocker NNP cord-014516-r59usk02 1145 18 spaniel spaniel NNP cord-014516-r59usk02 1145 19 , , , cord-014516-r59usk02 1145 20 crossbreed crossbreed NN cord-014516-r59usk02 1145 21 and and CC cord-014516-r59usk02 1145 22 golden golden JJ cord-014516-r59usk02 1145 23 retriever retriever NN cord-014516-r59usk02 1145 24 . . . cord-014516-r59usk02 1146 1 68 68 CD cord-014516-r59usk02 1146 2 sera sera NNP cord-014516-r59usk02 1146 3 displayed display VBD cord-014516-r59usk02 1146 4 a a DT cord-014516-r59usk02 1146 5 homogenous homogenous JJ cord-014516-r59usk02 1146 6 and and CC cord-014516-r59usk02 1146 7 140 140 CD cord-014516-r59usk02 1146 8 a a DT cord-014516-r59usk02 1146 9 speckled speckled JJ cord-014516-r59usk02 1146 10 IIF IIF NNP cord-014516-r59usk02 1146 11 ANA ANA NNP cord-014516-r59usk02 1146 12 fluorescence fluorescence NN cord-014516-r59usk02 1146 13 pattern pattern NN cord-014516-r59usk02 1146 14 . . . cord-014516-r59usk02 1147 1 Several several JJ cord-014516-r59usk02 1147 2 specific specific JJ cord-014516-r59usk02 1147 3 ANA ANA NNP cord-014516-r59usk02 1147 4 - - HYPH cord-014516-r59usk02 1147 5 reactivities reactivity NNS cord-014516-r59usk02 1147 6 earlier early RBR cord-014516-r59usk02 1147 7 characterized characterize VBN cord-014516-r59usk02 1147 8 in in IN cord-014516-r59usk02 1147 9 human human JJ cord-014516-r59usk02 1147 10 patients patient NNS cord-014516-r59usk02 1147 11 were be VBD cord-014516-r59usk02 1147 12 identified identify VBN cord-014516-r59usk02 1147 13 . . . cord-014516-r59usk02 1148 1 The the DT cord-014516-r59usk02 1148 2 majority majority NN cord-014516-r59usk02 1148 3 of of IN cord-014516-r59usk02 1148 4 ANA ANA NNP cord-014516-r59usk02 1148 5 H H NNP cord-014516-r59usk02 1148 6 , , , cord-014516-r59usk02 1148 7 n n NN cord-014516-r59usk02 1148 8 = = SYM cord-014516-r59usk02 1148 9 41 41 CD cord-014516-r59usk02 1148 10 , , , cord-014516-r59usk02 1148 11 60 60 CD cord-014516-r59usk02 1148 12 % % NN cord-014516-r59usk02 1148 13 , , , cord-014516-r59usk02 1148 14 showed show VBD cord-014516-r59usk02 1148 15 reactivity reactivity NN cord-014516-r59usk02 1148 16 against against IN cord-014516-r59usk02 1148 17 nucleosomal nucleosomal JJ cord-014516-r59usk02 1148 18 antigens antigen NNS cord-014516-r59usk02 1148 19 and and CC cord-014516-r59usk02 1148 20 9 9 CD cord-014516-r59usk02 1148 21 ( ( -LRB- cord-014516-r59usk02 1148 22 13 13 CD cord-014516-r59usk02 1148 23 % % NN cord-014516-r59usk02 1148 24 ) ) -RRB- cord-014516-r59usk02 1148 25 against against IN cord-014516-r59usk02 1148 26 dsDNA dsdna RB cord-014516-r59usk02 1148 27 when when WRB cord-014516-r59usk02 1148 28 conducted conduct VBN cord-014516-r59usk02 1148 29 on on IN cord-014516-r59usk02 1148 30 line line NN cord-014516-r59usk02 1148 31 blot blot NN cord-014516-r59usk02 1148 32 . . . cord-014516-r59usk02 1149 1 These these DT cord-014516-r59usk02 1149 2 sera sera NNP cord-014516-r59usk02 1149 3 also also RB cord-014516-r59usk02 1149 4 reacted react VBD cord-014516-r59usk02 1149 5 against against IN cord-014516-r59usk02 1149 6 nucleosomes nucleosome NNS cord-014516-r59usk02 1149 7 and and CC cord-014516-r59usk02 1149 8 dsDNA dsdna RB cord-014516-r59usk02 1149 9 on on IN cord-014516-r59usk02 1149 10 the the DT cord-014516-r59usk02 1149 11 ELISA ELISA NNP cord-014516-r59usk02 1149 12 . . . cord-014516-r59usk02 1150 1 There there EX cord-014516-r59usk02 1150 2 were be VBD cord-014516-r59usk02 1150 3 some some DT cord-014516-r59usk02 1150 4 additional additional JJ cord-014516-r59usk02 1150 5 positive positive JJ cord-014516-r59usk02 1150 6 with with IN cord-014516-r59usk02 1150 7 the the DT cord-014516-r59usk02 1150 8 ELISA ELISA NNP cord-014516-r59usk02 1150 9 , , , cord-014516-r59usk02 1150 10 so so RB cord-014516-r59usk02 1150 11 in in IN cord-014516-r59usk02 1150 12 total total NN cord-014516-r59usk02 1150 13 the the DT cord-014516-r59usk02 1150 14 ELISA ELISA NNP cord-014516-r59usk02 1150 15 identified identify VBD cord-014516-r59usk02 1150 16 72 72 CD cord-014516-r59usk02 1150 17 % % NN cord-014516-r59usk02 1150 18 with with IN cord-014516-r59usk02 1150 19 nucleosomal nucleosomal JJ cord-014516-r59usk02 1150 20 and and CC cord-014516-r59usk02 1150 21 24 24 CD cord-014516-r59usk02 1150 22 % % NN cord-014516-r59usk02 1150 23 with with IN cord-014516-r59usk02 1150 24 dsDNA dsdna JJ cord-014516-r59usk02 1150 25 reactivity reactivity NN cord-014516-r59usk02 1150 26 . . . cord-014516-r59usk02 1151 1 In in IN cord-014516-r59usk02 1151 2 few few JJ cord-014516-r59usk02 1151 3 cases case NNS cord-014516-r59usk02 1151 4 , , , cord-014516-r59usk02 1151 5 other other JJ cord-014516-r59usk02 1151 6 reactivities reactivity NNS cord-014516-r59usk02 1151 7 identified identify VBN cord-014516-r59usk02 1151 8 were be VBD cord-014516-r59usk02 1151 9 against against IN cord-014516-r59usk02 1151 10 histones histone NNS cord-014516-r59usk02 1151 11 , , , cord-014516-r59usk02 1151 12 PCNA PCNA NNP cord-014516-r59usk02 1151 13 , , , cord-014516-r59usk02 1151 14 Jo-1 Jo-1 NNP cord-014516-r59usk02 1151 15 and and CC cord-014516-r59usk02 1151 16 RNP RNP NNP cord-014516-r59usk02 1151 17 . . . cord-014516-r59usk02 1152 1 In in IN cord-014516-r59usk02 1152 2 the the DT cord-014516-r59usk02 1152 3 ANA ANA NNP cord-014516-r59usk02 1152 4 S S NNP cord-014516-r59usk02 1152 5 subgroup subgroup NN cord-014516-r59usk02 1152 6 , , , cord-014516-r59usk02 1152 7 the the DT cord-014516-r59usk02 1152 8 Sm+RNP Sm+RNP NNP cord-014516-r59usk02 1152 9 antigen antigen NN cord-014516-r59usk02 1152 10 evoked evoke VBD cord-014516-r59usk02 1152 11 the the DT cord-014516-r59usk02 1152 12 most most RBS cord-014516-r59usk02 1152 13 frequent frequent JJ cord-014516-r59usk02 1152 14 reactivity reactivity NN cord-014516-r59usk02 1152 15 , , , cord-014516-r59usk02 1152 16 n n NN cord-014516-r59usk02 1152 17 = = SYM cord-014516-r59usk02 1152 18 30 30 CD cord-014516-r59usk02 1152 19 , , , cord-014516-r59usk02 1152 20 21 21 CD cord-014516-r59usk02 1152 21 % % NN cord-014516-r59usk02 1152 22 with with IN cord-014516-r59usk02 1152 23 both both DT cord-014516-r59usk02 1152 24 line line NN cord-014516-r59usk02 1152 25 blot blot NN cord-014516-r59usk02 1152 26 and and CC cord-014516-r59usk02 1152 27 ELISA ELISA NNP cord-014516-r59usk02 1152 28 . . . cord-014516-r59usk02 1153 1 In in IN cord-014516-r59usk02 1153 2 few few JJ cord-014516-r59usk02 1153 3 cases case NNS cord-014516-r59usk02 1153 4 , , , cord-014516-r59usk02 1153 5 reactivity reactivity NN cord-014516-r59usk02 1153 6 against against IN cord-014516-r59usk02 1153 7 dsDNA dsdna RB cord-014516-r59usk02 1153 8 , , , cord-014516-r59usk02 1153 9 PCNA PCNA NNP cord-014516-r59usk02 1153 10 , , , cord-014516-r59usk02 1153 11 Jo-1 Jo-1 NNP cord-014516-r59usk02 1153 12 , , , cord-014516-r59usk02 1153 13 PMScl100kD pmscl100kd NN cord-014516-r59usk02 1153 14 , , , cord-014516-r59usk02 1153 15 Scl-70 Scl-70 NNP cord-014516-r59usk02 1153 16 , , , cord-014516-r59usk02 1153 17 SSA SSA NNP cord-014516-r59usk02 1153 18 and and CC cord-014516-r59usk02 1153 19 SSB SSB NNP cord-014516-r59usk02 1153 20 were be VBD cord-014516-r59usk02 1153 21 identified identify VBN cord-014516-r59usk02 1153 22 . . . cord-014516-r59usk02 1154 1 In in IN cord-014516-r59usk02 1154 2 several several JJ cord-014516-r59usk02 1154 3 dogs dog NNS cord-014516-r59usk02 1154 4 no no DT cord-014516-r59usk02 1154 5 specific specific JJ cord-014516-r59usk02 1154 6 antigen antigen NN cord-014516-r59usk02 1154 7 was be VBD cord-014516-r59usk02 1154 8 identified identify VBN cord-014516-r59usk02 1154 9 . . . cord-014516-r59usk02 1155 1 Further further JJ cord-014516-r59usk02 1155 2 studies study NNS cord-014516-r59usk02 1155 3 are be VBP cord-014516-r59usk02 1155 4 in in IN cord-014516-r59usk02 1155 5 progress progress NN cord-014516-r59usk02 1155 6 in in IN cord-014516-r59usk02 1155 7 order order NN cord-014516-r59usk02 1155 8 to to TO cord-014516-r59usk02 1155 9 in in IN cord-014516-r59usk02 1155 10 more more JJR cord-014516-r59usk02 1155 11 detail detail NN cord-014516-r59usk02 1155 12 characterize characterize VB cord-014516-r59usk02 1155 13 and and CC cord-014516-r59usk02 1155 14 identify identify VBP cord-014516-r59usk02 1155 15 subtypes subtype NNS cord-014516-r59usk02 1155 16 of of IN cord-014516-r59usk02 1155 17 already already RB cord-014516-r59usk02 1155 18 known know VBN cord-014516-r59usk02 1155 19 and and CC cord-014516-r59usk02 1155 20 unknown unknown JJ cord-014516-r59usk02 1155 21 antigens antigen NNS cord-014516-r59usk02 1155 22 with with IN cord-014516-r59usk02 1155 23 clinical clinical JJ cord-014516-r59usk02 1155 24 importance importance NN cord-014516-r59usk02 1155 25 in in IN cord-014516-r59usk02 1155 26 canine canine JJ cord-014516-r59usk02 1155 27 autoimmunity autoimmunity NN cord-014516-r59usk02 1155 28 . . . cord-014516-r59usk02 1156 1 One one CD cord-014516-r59usk02 1156 2 of of IN cord-014516-r59usk02 1156 3 the the DT cord-014516-r59usk02 1156 4 authors author NNS cord-014516-r59usk02 1156 5 , , , cord-014516-r59usk02 1156 6 Erik Erik NNP cord-014516-r59usk02 1156 7 Lattwein Lattwein NNP cord-014516-r59usk02 1156 8 , , , cord-014516-r59usk02 1156 9 is be VBZ cord-014516-r59usk02 1156 10 employed employ VBN cord-014516-r59usk02 1156 11 by by IN cord-014516-r59usk02 1156 12 EUROIMMUN EUROIMMUN NNP cord-014516-r59usk02 1156 13 where where WRB cord-014516-r59usk02 1156 14 the the DT cord-014516-r59usk02 1156 15 analyses analysis NNS cord-014516-r59usk02 1156 16 were be VBD cord-014516-r59usk02 1156 17 performed perform VBN cord-014516-r59usk02 1156 18 . . . cord-014516-r59usk02 1157 1 Chronic chronic JJ cord-014516-r59usk02 1157 2 kidney kidney NN cord-014516-r59usk02 1157 3 disease disease NN cord-014516-r59usk02 1157 4 ( ( -LRB- cord-014516-r59usk02 1157 5 CKD CKD NNP cord-014516-r59usk02 1157 6 ) ) -RRB- cord-014516-r59usk02 1157 7 has have VBZ cord-014516-r59usk02 1157 8 a a DT cord-014516-r59usk02 1157 9 high high JJ cord-014516-r59usk02 1157 10 prevalence prevalence NN cord-014516-r59usk02 1157 11 in in IN cord-014516-r59usk02 1157 12 cats cat NNS cord-014516-r59usk02 1157 13 . . . cord-014516-r59usk02 1158 1 Routine routine JJ cord-014516-r59usk02 1158 2 renal renal JJ cord-014516-r59usk02 1158 3 markers marker NNS cord-014516-r59usk02 1158 4 , , , cord-014516-r59usk02 1158 5 serum serum NN cord-014516-r59usk02 1158 6 creatinine creatinine NN cord-014516-r59usk02 1158 7 ( ( -LRB- cord-014516-r59usk02 1158 8 sCr sCr NNP cord-014516-r59usk02 1158 9 ) ) -RRB- cord-014516-r59usk02 1158 10 and and CC cord-014516-r59usk02 1158 11 urea urea NN cord-014516-r59usk02 1158 12 are be VBP cord-014516-r59usk02 1158 13 not not RB cord-014516-r59usk02 1158 14 sensitive sensitive JJ cord-014516-r59usk02 1158 15 or or CC cord-014516-r59usk02 1158 16 specific specific JJ cord-014516-r59usk02 1158 17 enough enough RB cord-014516-r59usk02 1158 18 to to TO cord-014516-r59usk02 1158 19 detect detect VB cord-014516-r59usk02 1158 20 early early JJ cord-014516-r59usk02 1158 21 CKD CKD NNP cord-014516-r59usk02 1158 22 . . . cord-014516-r59usk02 1159 1 Serum serum NN cord-014516-r59usk02 1159 2 Cystatin Cystatin NNP cord-014516-r59usk02 1159 3 C C NNP cord-014516-r59usk02 1159 4 ( ( -LRB- cord-014516-r59usk02 1159 5 sCysC sCysC NNP cord-014516-r59usk02 1159 6 ) ) -RRB- cord-014516-r59usk02 1159 7 has have VBZ cord-014516-r59usk02 1159 8 advantages advantage NNS cord-014516-r59usk02 1159 9 over over IN cord-014516-r59usk02 1159 10 sCr sCr NNS cord-014516-r59usk02 1159 11 for for IN cord-014516-r59usk02 1159 12 the the DT cord-014516-r59usk02 1159 13 detection detection NN cord-014516-r59usk02 1159 14 of of IN cord-014516-r59usk02 1159 15 early early JJ cord-014516-r59usk02 1159 16 kidney kidney NN cord-014516-r59usk02 1159 17 dysfunction dysfunction NN cord-014516-r59usk02 1159 18 , , , cord-014516-r59usk02 1159 19 both both DT cord-014516-r59usk02 1159 20 in in IN cord-014516-r59usk02 1159 21 humans human NNS cord-014516-r59usk02 1159 22 and and CC cord-014516-r59usk02 1159 23 dogs dog NNS cord-014516-r59usk02 1159 24 . . . cord-014516-r59usk02 1160 1 A a DT cord-014516-r59usk02 1160 2 significant significant JJ cord-014516-r59usk02 1160 3 higher high JJR cord-014516-r59usk02 1160 4 sCysC scysc JJ cord-014516-r59usk02 1160 5 concentration concentration NN cord-014516-r59usk02 1160 6 in in IN cord-014516-r59usk02 1160 7 CKD CKD NNP cord-014516-r59usk02 1160 8 cats cat NNS cord-014516-r59usk02 1160 9 has have VBZ cord-014516-r59usk02 1160 10 been be VBN cord-014516-r59usk02 1160 11 demonstrated demonstrate VBN cord-014516-r59usk02 1160 12 . . . cord-014516-r59usk02 1161 1 The the DT cord-014516-r59usk02 1161 2 objective objective NN cord-014516-r59usk02 1161 3 of of IN cord-014516-r59usk02 1161 4 this this DT cord-014516-r59usk02 1161 5 study study NN cord-014516-r59usk02 1161 6 was be VBD cord-014516-r59usk02 1161 7 to to TO cord-014516-r59usk02 1161 8 determine determine VB cord-014516-r59usk02 1161 9 the the DT cord-014516-r59usk02 1161 10 effect effect NN cord-014516-r59usk02 1161 11 of of IN cord-014516-r59usk02 1161 12 age age NN cord-014516-r59usk02 1161 13 , , , cord-014516-r59usk02 1161 14 gender gender NN cord-014516-r59usk02 1161 15 and and CC cord-014516-r59usk02 1161 16 breed breed NN cord-014516-r59usk02 1161 17 on on IN cord-014516-r59usk02 1161 18 feline feline JJ cord-014516-r59usk02 1161 19 sCysC scysc NN cord-014516-r59usk02 1161 20 and and CC cord-014516-r59usk02 1161 21 to to TO cord-014516-r59usk02 1161 22 establish establish VB cord-014516-r59usk02 1161 23 a a DT cord-014516-r59usk02 1161 24 reference reference NN cord-014516-r59usk02 1161 25 interval interval NN cord-014516-r59usk02 1161 26 for for IN cord-014516-r59usk02 1161 27 feline feline JJ cord-014516-r59usk02 1161 28 sCysC. scysc. NN cord-014516-r59usk02 1162 1 In in IN cord-014516-r59usk02 1162 2 total total NN cord-014516-r59usk02 1162 3 , , , cord-014516-r59usk02 1162 4 132 132 CD cord-014516-r59usk02 1162 5 healthy healthy JJ cord-014516-r59usk02 1162 6 cats cat NNS cord-014516-r59usk02 1162 7 between between IN cord-014516-r59usk02 1162 8 one one CD cord-014516-r59usk02 1162 9 and and CC cord-014516-r59usk02 1162 10 16 16 CD cord-014516-r59usk02 1162 11 years year NNS cord-014516-r59usk02 1162 12 were be VBD cord-014516-r59usk02 1162 13 included include VBN cord-014516-r59usk02 1162 14 . . . cord-014516-r59usk02 1163 1 Serum serum NN cord-014516-r59usk02 1163 2 CysC CysC NNP cord-014516-r59usk02 1163 3 was be VBD cord-014516-r59usk02 1163 4 determined determine VBN cord-014516-r59usk02 1163 5 with with IN cord-014516-r59usk02 1163 6 a a DT cord-014516-r59usk02 1163 7 validated validate VBN cord-014516-r59usk02 1163 8 particleenhanced particleenhance VBN cord-014516-r59usk02 1163 9 nephelometric nephelometric JJ cord-014516-r59usk02 1163 10 immunoassay immunoassay NN cord-014516-r59usk02 1163 11 ( ( -LRB- cord-014516-r59usk02 1163 12 PENIA PENIA NNP cord-014516-r59usk02 1163 13 ) ) -RRB- cord-014516-r59usk02 1163 14 . . . cord-014516-r59usk02 1164 1 Serum serum NN cord-014516-r59usk02 1164 2 Cr cr NN cord-014516-r59usk02 1164 3 , , , cord-014516-r59usk02 1164 4 urea urea NN cord-014516-r59usk02 1164 5 , , , cord-014516-r59usk02 1164 6 urine urine NN cord-014516-r59usk02 1164 7 specific specific JJ cord-014516-r59usk02 1164 8 gravity gravity NN cord-014516-r59usk02 1164 9 ( ( -LRB- cord-014516-r59usk02 1164 10 USG USG NNP cord-014516-r59usk02 1164 11 ) ) -RRB- cord-014516-r59usk02 1164 12 , , , cord-014516-r59usk02 1164 13 urinary urinary JJ cord-014516-r59usk02 1164 14 protein protein NN cord-014516-r59usk02 1164 15 : : : cord-014516-r59usk02 1164 16 creatinine creatinine NN cord-014516-r59usk02 1164 17 ratio ratio NN cord-014516-r59usk02 1164 18 ( ( -LRB- cord-014516-r59usk02 1164 19 UPC UPC NNP cord-014516-r59usk02 1164 20 ) ) -RRB- cord-014516-r59usk02 1164 21 and and CC cord-014516-r59usk02 1164 22 systolic systolic JJ cord-014516-r59usk02 1164 23 blood blood NN cord-014516-r59usk02 1164 24 pressure pressure NN cord-014516-r59usk02 1164 25 ( ( -LRB- cord-014516-r59usk02 1164 26 SBP SBP NNP cord-014516-r59usk02 1164 27 ) ) -RRB- cord-014516-r59usk02 1164 28 were be VBD cord-014516-r59usk02 1164 29 also also RB cord-014516-r59usk02 1164 30 measured measure VBN cord-014516-r59usk02 1164 31 . . . cord-014516-r59usk02 1165 1 To to TO cord-014516-r59usk02 1165 2 test test VB cord-014516-r59usk02 1165 3 for for IN cord-014516-r59usk02 1165 4 difference difference NN cord-014516-r59usk02 1165 5 between between IN cord-014516-r59usk02 1165 6 the the DT cord-014516-r59usk02 1165 7 groups group NNS cord-014516-r59usk02 1165 8 , , , cord-014516-r59usk02 1165 9 the the DT cord-014516-r59usk02 1165 10 F F NNP cord-014516-r59usk02 1165 11 - - HYPH cord-014516-r59usk02 1165 12 test test NN cord-014516-r59usk02 1165 13 was be VBD cord-014516-r59usk02 1165 14 used use VBN cord-014516-r59usk02 1165 15 . . . cord-014516-r59usk02 1166 1 The the DT cord-014516-r59usk02 1166 2 lower low JJR cord-014516-r59usk02 1166 3 and and CC cord-014516-r59usk02 1166 4 upper upper JJ cord-014516-r59usk02 1166 5 value value NN cord-014516-r59usk02 1166 6 of of IN cord-014516-r59usk02 1166 7 the the DT cord-014516-r59usk02 1166 8 95 95 CD cord-014516-r59usk02 1166 9 % % NN cord-014516-r59usk02 1166 10 reference reference NN cord-014516-r59usk02 1166 11 interval interval NN cord-014516-r59usk02 1166 12 were be VBD cord-014516-r59usk02 1166 13 obtained obtain VBN cord-014516-r59usk02 1166 14 as as IN cord-014516-r59usk02 1166 15 the the DT cord-014516-r59usk02 1166 16 2.5 2.5 CD cord-014516-r59usk02 1166 17 % % NN cord-014516-r59usk02 1166 18 and and CC cord-014516-r59usk02 1166 19 97.5 97.5 CD cord-014516-r59usk02 1166 20 % % NN cord-014516-r59usk02 1166 21 quantiles quantile NNS cord-014516-r59usk02 1166 22 of of IN cord-014516-r59usk02 1166 23 the the DT cord-014516-r59usk02 1166 24 sCysC sCysC NNP cord-014516-r59usk02 1166 25 observations observation NNS cord-014516-r59usk02 1166 26 . . . cord-014516-r59usk02 1167 1 No no DT cord-014516-r59usk02 1167 2 significant significant JJ cord-014516-r59usk02 1167 3 differences difference NNS cord-014516-r59usk02 1167 4 in in IN cord-014516-r59usk02 1167 5 sCysC scysc JJ cord-014516-r59usk02 1167 6 concentration concentration NN cord-014516-r59usk02 1167 7 were be VBD cord-014516-r59usk02 1167 8 observed observe VBN cord-014516-r59usk02 1167 9 between between IN cord-014516-r59usk02 1167 10 young young JJ cord-014516-r59usk02 1167 11 , , , cord-014516-r59usk02 1167 12 middle middle JJ cord-014516-r59usk02 1167 13 - - HYPH cord-014516-r59usk02 1167 14 aged aged JJ cord-014516-r59usk02 1167 15 and and CC cord-014516-r59usk02 1167 16 old old JJ cord-014516-r59usk02 1167 17 cats cat NNS cord-014516-r59usk02 1167 18 ; ; : cord-014516-r59usk02 1167 19 between between IN cord-014516-r59usk02 1167 20 female female JJ cord-014516-r59usk02 1167 21 , , , cord-014516-r59usk02 1167 22 female female JJ cord-014516-r59usk02 1167 23 neutered neuter VBN cord-014516-r59usk02 1167 24 , , , cord-014516-r59usk02 1167 25 male male JJ cord-014516-r59usk02 1167 26 and and CC cord-014516-r59usk02 1167 27 male male JJ cord-014516-r59usk02 1167 28 neutered neutered JJ cord-014516-r59usk02 1167 29 cats cat NNS cord-014516-r59usk02 1167 30 ; ; : cord-014516-r59usk02 1167 31 and and CC cord-014516-r59usk02 1167 32 between between IN cord-014516-r59usk02 1167 33 purebred purebred JJ cord-014516-r59usk02 1167 34 and and CC cord-014516-r59usk02 1167 35 domestic domestic JJ cord-014516-r59usk02 1167 36 short short JJ cord-014516-r59usk02 1167 37 - - HYPH cord-014516-r59usk02 1167 38 or or CC cord-014516-r59usk02 1167 39 longhaired longhaired JJ cord-014516-r59usk02 1167 40 cats cat NNS cord-014516-r59usk02 1167 41 . . . cord-014516-r59usk02 1168 1 The the DT cord-014516-r59usk02 1168 2 95 95 CD cord-014516-r59usk02 1168 3 % % NN cord-014516-r59usk02 1168 4 reference reference NN cord-014516-r59usk02 1168 5 interval interval NN cord-014516-r59usk02 1168 6 for for IN cord-014516-r59usk02 1168 7 feline feline JJ cord-014516-r59usk02 1168 8 sCysC scysc NN cord-014516-r59usk02 1168 9 was be VBD cord-014516-r59usk02 1168 10 determined determine VBN cord-014516-r59usk02 1168 11 as as IN cord-014516-r59usk02 1168 12 [ [ -LRB- cord-014516-r59usk02 1168 13 0.58 0.58 CD cord-014516-r59usk02 1168 14 - - SYM cord-014516-r59usk02 1168 15 1.95 1.95 CD cord-014516-r59usk02 1168 16 mg mg NNP cord-014516-r59usk02 1168 17 / / SYM cord-014516-r59usk02 1168 18 L L NNP cord-014516-r59usk02 1168 19 ] ] -RRB- cord-014516-r59usk02 1168 20 . . . cord-014516-r59usk02 1169 1 There there EX cord-014516-r59usk02 1169 2 was be VBD cord-014516-r59usk02 1169 3 a a DT cord-014516-r59usk02 1169 4 significant significant JJ cord-014516-r59usk02 1169 5 difference difference NN cord-014516-r59usk02 1169 6 in in IN cord-014516-r59usk02 1169 7 sCr scr NN cord-014516-r59usk02 1169 8 concentration concentration NN cord-014516-r59usk02 1169 9 between between IN cord-014516-r59usk02 1169 10 domestic domestic JJ cord-014516-r59usk02 1169 11 short short JJ cord-014516-r59usk02 1169 12 - - HYPH cord-014516-r59usk02 1169 13 or or CC cord-014516-r59usk02 1169 14 longhaired longhaired JJ cord-014516-r59usk02 1169 15 cats cat NNS cord-014516-r59usk02 1169 16 and and CC cord-014516-r59usk02 1169 17 purebred purebred JJ cord-014516-r59usk02 1169 18 cats cat NNS cord-014516-r59usk02 1169 19 . . . cord-014516-r59usk02 1170 1 The the DT cord-014516-r59usk02 1170 2 SBP SBP NNP cord-014516-r59usk02 1170 3 was be VBD cord-014516-r59usk02 1170 4 significantly significantly RB cord-014516-r59usk02 1170 5 influenced influence VBN cord-014516-r59usk02 1170 6 by by IN cord-014516-r59usk02 1170 7 gender gender NN cord-014516-r59usk02 1170 8 as as RB cord-014516-r59usk02 1170 9 well well RB cord-014516-r59usk02 1170 10 as as IN cord-014516-r59usk02 1170 11 age age NN cord-014516-r59usk02 1170 12 , , , cord-014516-r59usk02 1170 13 while while IN cord-014516-r59usk02 1170 14 urea urea NN cord-014516-r59usk02 1170 15 was be VBD cord-014516-r59usk02 1170 16 influenced influence VBN cord-014516-r59usk02 1170 17 by by IN cord-014516-r59usk02 1170 18 both both DT cord-014516-r59usk02 1170 19 age age NN cord-014516-r59usk02 1170 20 , , , cord-014516-r59usk02 1170 21 gender gender NN cord-014516-r59usk02 1170 22 and and CC cord-014516-r59usk02 1170 23 breed breed NN cord-014516-r59usk02 1170 24 . . . cord-014516-r59usk02 1171 1 This this DT cord-014516-r59usk02 1171 2 study study NN cord-014516-r59usk02 1171 3 showed show VBD cord-014516-r59usk02 1171 4 that that IN cord-014516-r59usk02 1171 5 the the DT cord-014516-r59usk02 1171 6 biological biological JJ cord-014516-r59usk02 1171 7 factors factor NNS cord-014516-r59usk02 1171 8 age age NN cord-014516-r59usk02 1171 9 , , , cord-014516-r59usk02 1171 10 gender gender NN cord-014516-r59usk02 1171 11 and and CC cord-014516-r59usk02 1171 12 breed breed NN cord-014516-r59usk02 1171 13 have have VBP cord-014516-r59usk02 1171 14 little little JJ cord-014516-r59usk02 1171 15 or or CC cord-014516-r59usk02 1171 16 no no DT cord-014516-r59usk02 1171 17 impact impact NN cord-014516-r59usk02 1171 18 on on IN cord-014516-r59usk02 1171 19 feline feline JJ cord-014516-r59usk02 1171 20 sCysC scysc NN cord-014516-r59usk02 1171 21 , , , cord-014516-r59usk02 1171 22 in in IN cord-014516-r59usk02 1171 23 contrast contrast NN cord-014516-r59usk02 1171 24 to to IN cord-014516-r59usk02 1171 25 sCr sCr NNS cord-014516-r59usk02 1171 26 and and CC cord-014516-r59usk02 1171 27 serum serum NN cord-014516-r59usk02 1171 28 urea urea NN cord-014516-r59usk02 1171 29 , , , cord-014516-r59usk02 1171 30 making make VBG cord-014516-r59usk02 1171 31 it -PRON- PRP cord-014516-r59usk02 1171 32 an an DT cord-014516-r59usk02 1171 33 interesting interesting JJ cord-014516-r59usk02 1171 34 marker marker NN cord-014516-r59usk02 1171 35 . . . cord-014516-r59usk02 1172 1 Therefore therefore RB cord-014516-r59usk02 1172 2 , , , cord-014516-r59usk02 1172 3 further further JJ cord-014516-r59usk02 1172 4 studies study NNS cord-014516-r59usk02 1172 5 are be VBP cord-014516-r59usk02 1172 6 warranted warrant VBN cord-014516-r59usk02 1172 7 to to TO cord-014516-r59usk02 1172 8 evaluate evaluate VB cord-014516-r59usk02 1172 9 the the DT cord-014516-r59usk02 1172 10 diagnostic diagnostic JJ cord-014516-r59usk02 1172 11 value value NN cord-014516-r59usk02 1172 12 of of IN cord-014516-r59usk02 1172 13 sCysC scysc NN cord-014516-r59usk02 1172 14 as as IN cord-014516-r59usk02 1172 15 a a DT cord-014516-r59usk02 1172 16 renal renal JJ cord-014516-r59usk02 1172 17 marker marker NN cord-014516-r59usk02 1172 18 in in IN cord-014516-r59usk02 1172 19 cats cat NNS cord-014516-r59usk02 1172 20 . . . cord-014516-r59usk02 1173 1 This this DT cord-014516-r59usk02 1173 2 study study NN cord-014516-r59usk02 1173 3 recieved recieve VBD cord-014516-r59usk02 1173 4 support support NN cord-014516-r59usk02 1173 5 from from IN cord-014516-r59usk02 1173 6 the the DT cord-014516-r59usk02 1173 7 Institute Institute NNP cord-014516-r59usk02 1173 8 for for IN cord-014516-r59usk02 1173 9 the the DT cord-014516-r59usk02 1173 10 Promotion Promotion NNP cord-014516-r59usk02 1173 11 of of IN cord-014516-r59usk02 1173 12 Innovation Innovation NNP cord-014516-r59usk02 1173 13 by by IN cord-014516-r59usk02 1173 14 Science Science NNP cord-014516-r59usk02 1173 15 and and CC cord-014516-r59usk02 1173 16 technology technology NN cord-014516-r59usk02 1173 17 in in IN cord-014516-r59usk02 1173 18 Flanders Flanders NNP cord-014516-r59usk02 1173 19 ( ( -LRB- cord-014516-r59usk02 1173 20 IWT IWT NNP cord-014516-r59usk02 1173 21 ) ) -RRB- cord-014516-r59usk02 1173 22 through through IN cord-014516-r59usk02 1173 23 a a DT cord-014516-r59usk02 1173 24 bursary bursary NN cord-014516-r59usk02 1173 25 to to IN cord-014516-r59usk02 1173 26 L. L. NNP cord-014516-r59usk02 1173 27 Ghys Ghys NNP cord-014516-r59usk02 1173 28 . . . cord-014516-r59usk02 1174 1 Assessment assessment NN cord-014516-r59usk02 1174 2 of of IN cord-014516-r59usk02 1174 3 renal renal JJ cord-014516-r59usk02 1174 4 function function NN cord-014516-r59usk02 1174 5 is be VBZ cord-014516-r59usk02 1174 6 often often RB cord-014516-r59usk02 1174 7 needed need VBN cord-014516-r59usk02 1174 8 , , , cord-014516-r59usk02 1174 9 however however RB cord-014516-r59usk02 1174 10 existing exist VBG cord-014516-r59usk02 1174 11 methods method NNS cord-014516-r59usk02 1174 12 including include VBG cord-014516-r59usk02 1174 13 urine urine NN cord-014516-r59usk02 1174 14 and and CC cord-014516-r59usk02 1174 15 plasma plasma NN cord-014516-r59usk02 1174 16 clearances clearance NNS cord-014516-r59usk02 1174 17 are be VBP cord-014516-r59usk02 1174 18 invasive invasive JJ cord-014516-r59usk02 1174 19 , , , cord-014516-r59usk02 1174 20 cumbersome cumbersome JJ cord-014516-r59usk02 1174 21 and and CC cord-014516-r59usk02 1174 22 time time NN cord-014516-r59usk02 1174 23 consuming consume VBG cord-014516-r59usk02 1174 24 . . . cord-014516-r59usk02 1175 1 In in IN cord-014516-r59usk02 1175 2 this this DT cord-014516-r59usk02 1175 3 pilot pilot NN cord-014516-r59usk02 1175 4 study study NN cord-014516-r59usk02 1175 5 the the DT cord-014516-r59usk02 1175 6 feasibility feasibility NN cord-014516-r59usk02 1175 7 of of IN cord-014516-r59usk02 1175 8 a a DT cord-014516-r59usk02 1175 9 transcutaneous transcutaneous JJ cord-014516-r59usk02 1175 10 glomerular glomerular JJ cord-014516-r59usk02 1175 11 filtration filtration NN cord-014516-r59usk02 1175 12 rate rate NN cord-014516-r59usk02 1175 13 measurement measurement NN cord-014516-r59usk02 1175 14 was be VBD cord-014516-r59usk02 1175 15 investigated investigate VBN cord-014516-r59usk02 1175 16 . . . cord-014516-r59usk02 1176 1 The the DT cord-014516-r59usk02 1176 2 transcutaneous transcutaneous JJ cord-014516-r59usk02 1176 3 disappearance disappearance NN cord-014516-r59usk02 1176 4 rate rate NN cord-014516-r59usk02 1176 5 ( ( -LRB- cord-014516-r59usk02 1176 6 expressed express VBN cord-014516-r59usk02 1176 7 as as IN cord-014516-r59usk02 1176 8 half half JJ cord-014516-r59usk02 1176 9 - - HYPH cord-014516-r59usk02 1176 10 life life NN cord-014516-r59usk02 1176 11 ) ) -RRB- cord-014516-r59usk02 1176 12 of of IN cord-014516-r59usk02 1176 13 fluorescein fluorescein NN cord-014516-r59usk02 1176 14 - - HYPH cord-014516-r59usk02 1176 15 isothiocyanatelabelled isothiocyanatelabelle VBN cord-014516-r59usk02 1176 16 sinistrin sinistrin NNP cord-014516-r59usk02 1177 1 ( ( -LRB- cord-014516-r59usk02 1177 2 FITC FITC NNP cord-014516-r59usk02 1177 3 - - HYPH cord-014516-r59usk02 1177 4 S S NNP cord-014516-r59usk02 1177 5 ) ) -RRB- cord-014516-r59usk02 1177 6 was be VBD cord-014516-r59usk02 1177 7 measured measure VBN cord-014516-r59usk02 1177 8 in in IN cord-014516-r59usk02 1177 9 three three CD cord-014516-r59usk02 1177 10 healthy healthy JJ cord-014516-r59usk02 1177 11 research research NN cord-014516-r59usk02 1177 12 dogs dog NNS cord-014516-r59usk02 1177 13 and and CC cord-014516-r59usk02 1177 14 three three CD cord-014516-r59usk02 1177 15 healthy healthy JJ cord-014516-r59usk02 1177 16 research research NN cord-014516-r59usk02 1177 17 cats cat NNS cord-014516-r59usk02 1177 18 . . . cord-014516-r59usk02 1178 1 Plasma plasma NN cord-014516-r59usk02 1178 2 clearance clearance NN cord-014516-r59usk02 1178 3 of of IN cord-014516-r59usk02 1178 4 sinistrin sinistrin NNP cord-014516-r59usk02 1178 5 ( ( -LRB- cord-014516-r59usk02 1178 6 7 7 CD cord-014516-r59usk02 1178 7 data data NN cord-014516-r59usk02 1178 8 points point NNS cord-014516-r59usk02 1178 9 ) ) -RRB- cord-014516-r59usk02 1178 10 was be VBD cord-014516-r59usk02 1178 11 performed perform VBN cord-014516-r59usk02 1178 12 in in IN cord-014516-r59usk02 1178 13 both both DT cord-014516-r59usk02 1178 14 species specie NNS cord-014516-r59usk02 1178 15 as as IN cord-014516-r59usk02 1178 16 previously previously RB cord-014516-r59usk02 1178 17 described describe VBN cord-014516-r59usk02 1178 18 ( ( -LRB- cord-014516-r59usk02 1178 19 Res Res NNP cord-014516-r59usk02 1178 20 Vet Vet NNP cord-014516-r59usk02 1178 21 Sci Sci NNP cord-014516-r59usk02 1178 22 1998 1998 CD cord-014516-r59usk02 1178 23 ; ; : cord-014516-r59usk02 1178 24 64:151 64:151 CD cord-014516-r59usk02 1178 25 - - SYM cord-014516-r59usk02 1178 26 6 6 CD cord-014516-r59usk02 1178 27 and and CC cord-014516-r59usk02 1178 28 J J NNP cord-014516-r59usk02 1178 29 Fel Fel NNP cord-014516-r59usk02 1178 30 Med Med NNP cord-014516-r59usk02 1178 31 Surg Surg NNP cord-014516-r59usk02 1178 32 2003 2003 CD cord-014516-r59usk02 1178 33 ; ; : cord-014516-r59usk02 1178 34 5:175 5:175 CD cord-014516-r59usk02 1178 35 - - SYM cord-014516-r59usk02 1178 36 81 81 CD cord-014516-r59usk02 1178 37 ) ) -RRB- cord-014516-r59usk02 1178 38 and and CC cord-014516-r59usk02 1178 39 half half JJ cord-014516-r59usk02 1178 40 - - HYPH cord-014516-r59usk02 1178 41 life life NN cord-014516-r59usk02 1178 42 was be VBD cord-014516-r59usk02 1178 43 calculated calculate VBN cord-014516-r59usk02 1178 44 using use VBG cord-014516-r59usk02 1178 45 a a DT cord-014516-r59usk02 1178 46 2-compartment 2-compartment CD cord-014516-r59usk02 1178 47 model model NN cord-014516-r59usk02 1178 48 with with IN cord-014516-r59usk02 1178 49 a a DT cord-014516-r59usk02 1178 50 freely freely RB cord-014516-r59usk02 1178 51 available available JJ cord-014516-r59usk02 1178 52 pharmacokinetic pharmacokinetic JJ cord-014516-r59usk02 1178 53 calculator calculator NN cord-014516-r59usk02 1178 54 ( ( -LRB- cord-014516-r59usk02 1178 55 Comput Comput NNP cord-014516-r59usk02 1178 56 Meth Meth NNP cord-014516-r59usk02 1178 57 Prog Prog NNP cord-014516-r59usk02 1178 58 Bio Bio NNP cord-014516-r59usk02 1178 59 2010 2010 CD cord-014516-r59usk02 1178 60 ; ; : cord-014516-r59usk02 1178 61 99:306 99:306 CD cord-014516-r59usk02 1178 62 - - SYM cord-014516-r59usk02 1178 63 14 14 CD cord-014516-r59usk02 1178 64 ) ) -RRB- cord-014516-r59usk02 1178 65 . . . cord-014516-r59usk02 1179 1 Renal renal JJ cord-014516-r59usk02 1179 2 elimination elimination NN cord-014516-r59usk02 1179 3 of of IN cord-014516-r59usk02 1179 4 FITC FITC NNP cord-014516-r59usk02 1179 5 - - HYPH cord-014516-r59usk02 1179 6 S S NNP cord-014516-r59usk02 1179 7 was be VBD cord-014516-r59usk02 1179 8 measured measure VBN cord-014516-r59usk02 1179 9 transcutaneously transcutaneously NN cord-014516-r59usk02 1179 10 for for IN cord-014516-r59usk02 1179 11 4 4 CD cord-014516-r59usk02 1179 12 hours hour NNS cord-014516-r59usk02 1179 13 ( ( -LRB- cord-014516-r59usk02 1179 14 7000 7000 CD cord-014516-r59usk02 1179 15 - - SYM cord-014516-r59usk02 1179 16 8000 8000 CD cord-014516-r59usk02 1179 17 data data NN cord-014516-r59usk02 1179 18 points point NNS cord-014516-r59usk02 1179 19 ) ) -RRB- cord-014516-r59usk02 1179 20 using use VBG cord-014516-r59usk02 1179 21 a a DT cord-014516-r59usk02 1179 22 miniaturized miniaturized JJ cord-014516-r59usk02 1179 23 device device NN cord-014516-r59usk02 1179 24 as as IN cord-014516-r59usk02 1179 25 described describe VBN cord-014516-r59usk02 1179 26 previously previously RB cord-014516-r59usk02 1179 27 for for IN cord-014516-r59usk02 1179 28 the the DT cord-014516-r59usk02 1179 29 same same JJ cord-014516-r59usk02 1179 30 purpose purpose NN cord-014516-r59usk02 1179 31 in in IN cord-014516-r59usk02 1179 32 rats rat NNS cord-014516-r59usk02 1179 33 ( ( -LRB- cord-014516-r59usk02 1179 34 Kidney Kidney NNP cord-014516-r59usk02 1179 35 Int Int NNP cord-014516-r59usk02 1179 36 2011 2011 CD cord-014516-r59usk02 1179 37 79:1254 79:1254 CD cord-014516-r59usk02 1179 38 - - SYM cord-014516-r59usk02 1179 39 8 8 CD cord-014516-r59usk02 1179 40 ) ) -RRB- cord-014516-r59usk02 1179 41 . . . cord-014516-r59usk02 1180 1 The the DT cord-014516-r59usk02 1180 2 procedures procedure NNS cord-014516-r59usk02 1180 3 were be VBD cord-014516-r59usk02 1180 4 performed perform VBN cord-014516-r59usk02 1180 5 in in IN cord-014516-r59usk02 1180 6 awake awake JJ cord-014516-r59usk02 1180 7 , , , cord-014516-r59usk02 1180 8 freely freely RB cord-014516-r59usk02 1180 9 moving move VBG cord-014516-r59usk02 1180 10 animals animal NNS cord-014516-r59usk02 1180 11 using use VBG cord-014516-r59usk02 1180 12 escalating escalate VBG cord-014516-r59usk02 1180 13 doses dose NNS cord-014516-r59usk02 1180 14 of of IN cord-014516-r59usk02 1180 15 FITC FITC NNP cord-014516-r59usk02 1180 16 - - HYPH cord-014516-r59usk02 1180 17 S S NNP cord-014516-r59usk02 1180 18 ( ( -LRB- cord-014516-r59usk02 1180 19 10 10 CD cord-014516-r59usk02 1180 20 mg mg NNP cord-014516-r59usk02 1180 21 / / SYM cord-014516-r59usk02 1180 22 kg kg NNP cord-014516-r59usk02 1180 23 , , , cord-014516-r59usk02 1180 24 30 30 CD cord-014516-r59usk02 1180 25 mg mg NN cord-014516-r59usk02 1180 26 / / SYM cord-014516-r59usk02 1180 27 kg kg NNP cord-014516-r59usk02 1180 28 , , , cord-014516-r59usk02 1180 29 50 50 CD cord-014516-r59usk02 1180 30 mg mg NNP cord-014516-r59usk02 1180 31 / / SYM cord-014516-r59usk02 1180 32 kg kg NNP cord-014516-r59usk02 1180 33 ) ) -RRB- cord-014516-r59usk02 1180 34 with with IN cord-014516-r59usk02 1180 35 a a DT cord-014516-r59usk02 1180 36 wash wash NN cord-014516-r59usk02 1180 37 - - HYPH cord-014516-r59usk02 1180 38 out out RP cord-014516-r59usk02 1180 39 period period NN cord-014516-r59usk02 1180 40 of of IN cord-014516-r59usk02 1180 41 at at RB cord-014516-r59usk02 1180 42 least least JJS cord-014516-r59usk02 1180 43 24 24 CD cord-014516-r59usk02 1180 44 h h NN cord-014516-r59usk02 1180 45 in in IN cord-014516-r59usk02 1180 46 each each DT cord-014516-r59usk02 1180 47 animal animal NN cord-014516-r59usk02 1180 48 . . . cord-014516-r59usk02 1181 1 To to TO cord-014516-r59usk02 1181 2 find find VB cord-014516-r59usk02 1181 3 the the DT cord-014516-r59usk02 1181 4 best good JJS cord-014516-r59usk02 1181 5 position position NN cord-014516-r59usk02 1181 6 for for IN cord-014516-r59usk02 1181 7 the the DT cord-014516-r59usk02 1181 8 device device NN cord-014516-r59usk02 1181 9 , , , cord-014516-r59usk02 1181 10 multiple multiple JJ cord-014516-r59usk02 1181 11 devices device NNS cord-014516-r59usk02 1181 12 were be VBD cord-014516-r59usk02 1181 13 placed place VBN cord-014516-r59usk02 1181 14 on on IN cord-014516-r59usk02 1181 15 each each DT cord-014516-r59usk02 1181 16 animal animal NN cord-014516-r59usk02 1181 17 . . . cord-014516-r59usk02 1182 1 The the DT cord-014516-r59usk02 1182 2 resulting result VBG cord-014516-r59usk02 1182 3 FITC FITC NNP cord-014516-r59usk02 1182 4 - - HYPH cord-014516-r59usk02 1182 5 S s NN cord-014516-r59usk02 1182 6 disappearance disappearance NN cord-014516-r59usk02 1182 7 curves curve NNS cord-014516-r59usk02 1182 8 were be VBD cord-014516-r59usk02 1182 9 visually visually RB cord-014516-r59usk02 1182 10 assessed assess VBN cord-014516-r59usk02 1182 11 to to TO cord-014516-r59usk02 1182 12 determine determine VB cord-014516-r59usk02 1182 13 the the DT cord-014516-r59usk02 1182 14 most most RBS cord-014516-r59usk02 1182 15 suitable suitable JJ cord-014516-r59usk02 1182 16 location location NN cord-014516-r59usk02 1182 17 and and CC cord-014516-r59usk02 1182 18 the the DT cord-014516-r59usk02 1182 19 appropriate appropriate JJ cord-014516-r59usk02 1182 20 dose dose NN cord-014516-r59usk02 1182 21 to to TO cord-014516-r59usk02 1182 22 reach reach VB cord-014516-r59usk02 1182 23 an an DT cord-014516-r59usk02 1182 24 adequate adequate JJ cord-014516-r59usk02 1182 25 transcutaneous transcutaneous JJ cord-014516-r59usk02 1182 26 peak peak NN cord-014516-r59usk02 1182 27 signal signal NN cord-014516-r59usk02 1182 28 for for IN cord-014516-r59usk02 1182 29 kinetic kinetic JJ cord-014516-r59usk02 1182 30 analysis analysis NN cord-014516-r59usk02 1182 31 . . . cord-014516-r59usk02 1183 1 In in IN cord-014516-r59usk02 1183 2 both both DT cord-014516-r59usk02 1183 3 species specie NNS cord-014516-r59usk02 1183 4 30 30 CD cord-014516-r59usk02 1183 5 mg mg NN cord-014516-r59usk02 1183 6 / / SYM cord-014516-r59usk02 1183 7 kg kg NNS cord-014516-r59usk02 1183 8 were be VBD cord-014516-r59usk02 1183 9 adequate adequate JJ cord-014516-r59usk02 1183 10 for for IN cord-014516-r59usk02 1183 11 kinetic kinetic JJ cord-014516-r59usk02 1183 12 calculation calculation NN cord-014516-r59usk02 1183 13 . . . cord-014516-r59usk02 1184 1 The the DT cord-014516-r59usk02 1184 2 most most RBS cord-014516-r59usk02 1184 3 suitable suitable JJ cord-014516-r59usk02 1184 4 place place NN cord-014516-r59usk02 1184 5 for for IN cord-014516-r59usk02 1184 6 the the DT cord-014516-r59usk02 1184 7 device device NN cord-014516-r59usk02 1184 8 was be VBD cord-014516-r59usk02 1184 9 the the DT cord-014516-r59usk02 1184 10 lateral lateral JJ cord-014516-r59usk02 1184 11 thoracic thoracic JJ cord-014516-r59usk02 1184 12 wall wall NN cord-014516-r59usk02 1184 13 in in IN cord-014516-r59usk02 1184 14 dogs dog NNS cord-014516-r59usk02 1184 15 and and CC cord-014516-r59usk02 1184 16 the the DT cord-014516-r59usk02 1184 17 ventral ventral JJ cord-014516-r59usk02 1184 18 abdominal abdominal JJ cord-014516-r59usk02 1184 19 wall wall NN cord-014516-r59usk02 1184 20 in in IN cord-014516-r59usk02 1184 21 cats cat NNS cord-014516-r59usk02 1184 22 , , , cord-014516-r59usk02 1184 23 respectively respectively RB cord-014516-r59usk02 1184 24 . . . cord-014516-r59usk02 1185 1 Transcutaneous transcutaneous JJ cord-014516-r59usk02 1185 2 FITC FITC NNP cord-014516-r59usk02 1185 3 - - HYPH cord-014516-r59usk02 1185 4 S s NN cord-014516-r59usk02 1185 5 clearance clearance NN cord-014516-r59usk02 1185 6 was be VBD cord-014516-r59usk02 1185 7 then then RB cord-014516-r59usk02 1185 8 repeated repeat VBN cord-014516-r59usk02 1185 9 using use VBG cord-014516-r59usk02 1185 10 the the DT cord-014516-r59usk02 1185 11 optimal optimal JJ cord-014516-r59usk02 1185 12 dose dose NN cord-014516-r59usk02 1185 13 and and CC cord-014516-r59usk02 1185 14 location location NN cord-014516-r59usk02 1185 15 and and CC cord-014516-r59usk02 1185 16 in in IN cord-014516-r59usk02 1185 17 parallel parallel NN cord-014516-r59usk02 1185 18 with with IN cord-014516-r59usk02 1185 19 the the DT cord-014516-r59usk02 1185 20 plasma plasma NN cord-014516-r59usk02 1185 21 sinistrin sinistrin NN cord-014516-r59usk02 1185 22 clearance clearance NN cord-014516-r59usk02 1185 23 . . . cord-014516-r59usk02 1186 1 Plasma plasma NN cord-014516-r59usk02 1186 2 sinistrin sinistrin NN cord-014516-r59usk02 1186 3 clearances clearance NNS cord-014516-r59usk02 1186 4 [ [ -LRB- cord-014516-r59usk02 1186 5 ml ml NN cord-014516-r59usk02 1186 6 / / SYM cord-014516-r59usk02 1186 7 kg kg NNP cord-014516-r59usk02 1186 8 / / SYM cord-014516-r59usk02 1186 9 min min NN cord-014516-r59usk02 1186 10 ] ] -RRB- cord-014516-r59usk02 1186 11 were be VBD cord-014516-r59usk02 1186 12 5.5 5.5 CD cord-014516-r59usk02 1186 13 , , , cord-014516-r59usk02 1186 14 5.0 5.0 CD cord-014516-r59usk02 1186 15 and and CC cord-014516-r59usk02 1186 16 3.8 3.8 CD cord-014516-r59usk02 1186 17 in in IN cord-014516-r59usk02 1186 18 the the DT cord-014516-r59usk02 1186 19 three three CD cord-014516-r59usk02 1186 20 dogs dog NNS cord-014516-r59usk02 1186 21 , , , cord-014516-r59usk02 1186 22 respectively respectively RB cord-014516-r59usk02 1186 23 . . . cord-014516-r59usk02 1187 1 Corresponding correspond VBG cord-014516-r59usk02 1187 2 plasma plasma NN cord-014516-r59usk02 1187 3 elimination elimination NN cord-014516-r59usk02 1188 1 half half RB cord-014516-r59usk02 1188 2 - - HYPH cord-014516-r59usk02 1188 3 lives life NNS cord-014516-r59usk02 1188 4 [ [ -LRB- cord-014516-r59usk02 1188 5 min min NN cord-014516-r59usk02 1188 6 ] ] -RRB- cord-014516-r59usk02 1188 7 were be VBD cord-014516-r59usk02 1188 8 26 26 CD cord-014516-r59usk02 1188 9 , , , cord-014516-r59usk02 1188 10 31 31 CD cord-014516-r59usk02 1188 11 and and CC cord-014516-r59usk02 1188 12 35 35 CD cord-014516-r59usk02 1188 13 , , , cord-014516-r59usk02 1188 14 and and CC cord-014516-r59usk02 1188 15 corresponding correspond VBG cord-014516-r59usk02 1188 16 transcutaneous transcutaneous JJ cord-014516-r59usk02 1188 17 elimination elimination NN cord-014516-r59usk02 1188 18 half half RB cord-014516-r59usk02 1188 19 - - HYPH cord-014516-r59usk02 1188 20 lives life NNS cord-014516-r59usk02 1188 21 [ [ -LRB- cord-014516-r59usk02 1188 22 min min NN cord-014516-r59usk02 1188 23 ] ] -RRB- cord-014516-r59usk02 1188 24 were be VBD cord-014516-r59usk02 1188 25 26 26 CD cord-014516-r59usk02 1188 26 , , , cord-014516-r59usk02 1188 27 34 34 CD cord-014516-r59usk02 1188 28 and and CC cord-014516-r59usk02 1188 29 55 55 CD cord-014516-r59usk02 1188 30 , , , cord-014516-r59usk02 1188 31 respectively respectively RB cord-014516-r59usk02 1188 32 . . . cord-014516-r59usk02 1189 1 Plasma plasma NN cord-014516-r59usk02 1189 2 sinistrin sinistrin NN cord-014516-r59usk02 1189 3 clearances clearance NNS cord-014516-r59usk02 1189 4 [ [ -LRB- cord-014516-r59usk02 1189 5 ml ml NN cord-014516-r59usk02 1189 6 / / SYM cord-014516-r59usk02 1189 7 kg kg NNP cord-014516-r59usk02 1189 8 / / SYM cord-014516-r59usk02 1189 9 min min NN cord-014516-r59usk02 1189 10 ] ] -RRB- cord-014516-r59usk02 1189 11 were be VBD cord-014516-r59usk02 1189 12 2.8 2.8 CD cord-014516-r59usk02 1189 13 , , , cord-014516-r59usk02 1189 14 2.2 2.2 CD cord-014516-r59usk02 1189 15 and and CC cord-014516-r59usk02 1189 16 1.9 1.9 CD cord-014516-r59usk02 1189 17 in in IN cord-014516-r59usk02 1189 18 the the DT cord-014516-r59usk02 1189 19 three three CD cord-014516-r59usk02 1189 20 cats cat NNS cord-014516-r59usk02 1189 21 , , , cord-014516-r59usk02 1189 22 respectively respectively RB cord-014516-r59usk02 1189 23 . . . cord-014516-r59usk02 1190 1 Corresponding correspond VBG cord-014516-r59usk02 1190 2 plasma plasma NN cord-014516-r59usk02 1190 3 elimination elimination NN cord-014516-r59usk02 1191 1 half half RB cord-014516-r59usk02 1191 2 - - HYPH cord-014516-r59usk02 1191 3 lives life NNS cord-014516-r59usk02 1191 4 [ [ -LRB- cord-014516-r59usk02 1191 5 min min NN cord-014516-r59usk02 1191 6 ] ] -RRB- cord-014516-r59usk02 1191 7 were be VBD cord-014516-r59usk02 1191 8 51 51 CD cord-014516-r59usk02 1191 9 , , , cord-014516-r59usk02 1191 10 60 60 CD cord-014516-r59usk02 1191 11 and and CC cord-014516-r59usk02 1191 12 61 61 CD cord-014516-r59usk02 1191 13 , , , cord-014516-r59usk02 1191 14 and and CC cord-014516-r59usk02 1191 15 corresponding correspond VBG cord-014516-r59usk02 1191 16 transcutaneous transcutaneous JJ cord-014516-r59usk02 1191 17 elimination elimination NN cord-014516-r59usk02 1191 18 half half RB cord-014516-r59usk02 1191 19 - - HYPH cord-014516-r59usk02 1191 20 lives life NNS cord-014516-r59usk02 1191 21 [ [ -LRB- cord-014516-r59usk02 1191 22 min min NN cord-014516-r59usk02 1191 23 ] ] -RRB- cord-014516-r59usk02 1191 24 were be VBD cord-014516-r59usk02 1191 25 75 75 CD cord-014516-r59usk02 1191 26 , , , cord-014516-r59usk02 1191 27 96 96 CD cord-014516-r59usk02 1191 28 and and CC cord-014516-r59usk02 1191 29 83 83 CD cord-014516-r59usk02 1191 30 , , , cord-014516-r59usk02 1191 31 respectively respectively RB cord-014516-r59usk02 1191 32 . . . cord-014516-r59usk02 1192 1 In in IN cord-014516-r59usk02 1192 2 conclusion conclusion NN cord-014516-r59usk02 1192 3 , , , cord-014516-r59usk02 1192 4 transcutaneous transcutaneous JJ cord-014516-r59usk02 1192 5 FITC FITC NNP cord-014516-r59usk02 1192 6 - - HYPH cord-014516-r59usk02 1192 7 S s NN cord-014516-r59usk02 1192 8 clearance clearance NN cord-014516-r59usk02 1192 9 is be VBZ cord-014516-r59usk02 1192 10 a a DT cord-014516-r59usk02 1192 11 feasible feasible JJ cord-014516-r59usk02 1192 12 method method NN cord-014516-r59usk02 1192 13 for for IN cord-014516-r59usk02 1192 14 assessment assessment NN cord-014516-r59usk02 1192 15 of of IN cord-014516-r59usk02 1192 16 GFR GFR NNP cord-014516-r59usk02 1192 17 in in IN cord-014516-r59usk02 1192 18 awake awake JJ cord-014516-r59usk02 1192 19 dogs dog NNS cord-014516-r59usk02 1192 20 and and CC cord-014516-r59usk02 1192 21 cats cat NNS cord-014516-r59usk02 1192 22 . . . cord-014516-r59usk02 1193 1 It -PRON- PRP cord-014516-r59usk02 1193 2 is be VBZ cord-014516-r59usk02 1193 3 noninvasive noninvasive JJ cord-014516-r59usk02 1193 4 , , , cord-014516-r59usk02 1193 5 well well RB cord-014516-r59usk02 1193 6 tolerated tolerated JJ cord-014516-r59usk02 1193 7 and and CC cord-014516-r59usk02 1193 8 easy easy JJ cord-014516-r59usk02 1193 9 to to TO cord-014516-r59usk02 1193 10 perform perform VB cord-014516-r59usk02 1193 11 even even RB cord-014516-r59usk02 1193 12 in in IN cord-014516-r59usk02 1193 13 a a DT cord-014516-r59usk02 1193 14 clinical clinical JJ cord-014516-r59usk02 1193 15 setting setting NN cord-014516-r59usk02 1193 16 with with IN cord-014516-r59usk02 1193 17 results result NNS cord-014516-r59usk02 1193 18 being be VBG cord-014516-r59usk02 1193 19 readily readily RB cord-014516-r59usk02 1193 20 available available JJ cord-014516-r59usk02 1193 21 . . . cord-014516-r59usk02 1194 1 A a DT cord-014516-r59usk02 1194 2 dose dose NN cord-014516-r59usk02 1194 3 of of IN cord-014516-r59usk02 1194 4 30 30 CD cord-014516-r59usk02 1194 5 mg mg NN cord-014516-r59usk02 1194 6 / / SYM cord-014516-r59usk02 1194 7 kg kg NNS cord-014516-r59usk02 1194 8 of of IN cord-014516-r59usk02 1194 9 FITC FITC NNP cord-014516-r59usk02 1194 10 - - HYPH cord-014516-r59usk02 1194 11 S S NNP cord-014516-r59usk02 1194 12 seems seem VBZ cord-014516-r59usk02 1194 13 adequate adequate JJ cord-014516-r59usk02 1194 14 for for IN cord-014516-r59usk02 1194 15 kinetic kinetic JJ cord-014516-r59usk02 1194 16 assessment assessment NN cord-014516-r59usk02 1194 17 . . . cord-014516-r59usk02 1195 1 Further further JJ cord-014516-r59usk02 1195 2 studies study NNS cord-014516-r59usk02 1195 3 are be VBP cord-014516-r59usk02 1195 4 now now RB cord-014516-r59usk02 1195 5 needed need VBN cord-014516-r59usk02 1195 6 to to TO cord-014516-r59usk02 1195 7 establish establish VB cord-014516-r59usk02 1195 8 reference reference NN cord-014516-r59usk02 1195 9 values value NNS cord-014516-r59usk02 1195 10 and and CC cord-014516-r59usk02 1195 11 evaluate evaluate VB cord-014516-r59usk02 1195 12 transcutaneous transcutaneous JJ cord-014516-r59usk02 1195 13 renal renal JJ cord-014516-r59usk02 1195 14 clearance clearance NN cord-014516-r59usk02 1195 15 in in IN cord-014516-r59usk02 1195 16 various various JJ cord-014516-r59usk02 1195 17 conditions condition NNS cord-014516-r59usk02 1195 18 . . . cord-014516-r59usk02 1196 1 Conflicts conflict NNS cord-014516-r59usk02 1196 2 of of IN cord-014516-r59usk02 1196 3 interest interest NN cord-014516-r59usk02 1196 4 : : : cord-014516-r59usk02 1196 5 ZHP ZHP NNP cord-014516-r59usk02 1196 6 and and CC cord-014516-r59usk02 1196 7 SG SG NNP cord-014516-r59usk02 1196 8 are be VBP cord-014516-r59usk02 1196 9 supported support VBN cord-014516-r59usk02 1196 10 by by IN cord-014516-r59usk02 1196 11 the the DT cord-014516-r59usk02 1196 12 EC EC NNP cord-014516-r59usk02 1196 13 FP7 FP7 NNP cord-014516-r59usk02 1196 14 Marie Marie NNP cord-014516-r59usk02 1196 15 - - HYPH cord-014516-r59usk02 1196 16 Curie Curie NNP cord-014516-r59usk02 1196 17 programme programme NN cord-014516-r59usk02 1196 18 : : : cord-014516-r59usk02 1196 19 NephroTools NephroTools NNP cord-014516-r59usk02 1196 20 . . . cord-014516-r59usk02 1197 1 The the DT cord-014516-r59usk02 1197 2 device device NN cord-014516-r59usk02 1197 3 development development NN cord-014516-r59usk02 1197 4 was be VBD cord-014516-r59usk02 1197 5 supported support VBN cord-014516-r59usk02 1197 6 by by IN cord-014516-r59usk02 1197 7 the the DT cord-014516-r59usk02 1197 8 FP7 FP7 NNP cord-014516-r59usk02 1197 9 activity activity NN cord-014516-r59usk02 1197 10 : : : cord-014516-r59usk02 1197 11 PLACE place NN cord-014516-r59usk02 1197 12 - - : cord-014516-r59usk02 1197 13 it -PRON- PRP cord-014516-r59usk02 1197 14 . . . cord-014516-r59usk02 1198 1 NG NG NNP cord-014516-r59usk02 1198 2 is be VBZ cord-014516-r59usk02 1198 3 owner owner NN cord-014516-r59usk02 1198 4 of of IN cord-014516-r59usk02 1198 5 a a DT cord-014516-r59usk02 1198 6 patent patent NN cord-014516-r59usk02 1198 7 covering cover VBG cord-014516-r59usk02 1198 8 FITC FITC NNP cord-014516-r59usk02 1198 9 - - HYPH cord-014516-r59usk02 1198 10 sinistrin sinistrin NNP cord-014516-r59usk02 1198 11 and and CC cord-014516-r59usk02 1198 12 the the DT cord-014516-r59usk02 1198 13 technology technology NN cord-014516-r59usk02 1198 14 for for IN cord-014516-r59usk02 1198 15 its -PRON- PRP$ cord-014516-r59usk02 1198 16 measurement measurement NN cord-014516-r59usk02 1198 17 . . . cord-014516-r59usk02 1199 1 Excretion excretion NN cord-014516-r59usk02 1199 2 of of IN cord-014516-r59usk02 1199 3 urinary urinary JJ cord-014516-r59usk02 1199 4 biomarkers biomarker NNS cord-014516-r59usk02 1199 5 of of IN cord-014516-r59usk02 1199 6 renal renal JJ cord-014516-r59usk02 1199 7 damage damage NN cord-014516-r59usk02 1199 8 should should MD cord-014516-r59usk02 1199 9 occur occur VB cord-014516-r59usk02 1199 10 at at IN cord-014516-r59usk02 1199 11 an an DT cord-014516-r59usk02 1199 12 early early JJ cord-014516-r59usk02 1199 13 stage stage NN cord-014516-r59usk02 1199 14 of of IN cord-014516-r59usk02 1199 15 chronic chronic JJ cord-014516-r59usk02 1199 16 kidney kidney NN cord-014516-r59usk02 1199 17 disease disease NN cord-014516-r59usk02 1199 18 ( ( -LRB- cord-014516-r59usk02 1199 19 CKD CKD NNP cord-014516-r59usk02 1199 20 ) ) -RRB- cord-014516-r59usk02 1199 21 , , , cord-014516-r59usk02 1199 22 thus thus RB cord-014516-r59usk02 1199 23 facilitating facilitate VBG cord-014516-r59usk02 1199 24 earlier early JJR cord-014516-r59usk02 1199 25 diagnosis diagnosis NN cord-014516-r59usk02 1199 26 of of IN cord-014516-r59usk02 1199 27 renal renal JJ cord-014516-r59usk02 1199 28 disease disease NN cord-014516-r59usk02 1199 29 . . . cord-014516-r59usk02 1200 1 Albumin albumin NN cord-014516-r59usk02 1200 2 and and CC cord-014516-r59usk02 1200 3 cystatin cystatin NNP cord-014516-r59usk02 1200 4 C c NN cord-014516-r59usk02 1200 5 in in IN cord-014516-r59usk02 1200 6 the the DT cord-014516-r59usk02 1200 7 renal renal JJ cord-014516-r59usk02 1200 8 ultrafiltrate ultrafiltrate NN cord-014516-r59usk02 1200 9 are be VBP cord-014516-r59usk02 1200 10 mostly mostly RB cord-014516-r59usk02 1200 11 reabsorbed reabsorb VBN cord-014516-r59usk02 1200 12 by by IN cord-014516-r59usk02 1200 13 the the DT cord-014516-r59usk02 1200 14 proximal proximal JJ cord-014516-r59usk02 1200 15 tubular tubular JJ cord-014516-r59usk02 1200 16 cells cell NNS cord-014516-r59usk02 1200 17 , , , cord-014516-r59usk02 1200 18 therefore therefore RB cord-014516-r59usk02 1200 19 increased increase VBD cord-014516-r59usk02 1200 20 urinary urinary JJ cord-014516-r59usk02 1200 21 excretion excretion NN cord-014516-r59usk02 1200 22 of of IN cord-014516-r59usk02 1200 23 albumin albumin NN cord-014516-r59usk02 1200 24 and and CC cord-014516-r59usk02 1200 25 cystatin cystatin NNP cord-014516-r59usk02 1200 26 C c NN cord-014516-r59usk02 1200 27 ( ( -LRB- cord-014516-r59usk02 1200 28 UAC UAC NNP cord-014516-r59usk02 1200 29 and and CC cord-014516-r59usk02 1200 30 UCysC UCysC NNP cord-014516-r59usk02 1200 31 ) ) -RRB- cord-014516-r59usk02 1200 32 would would MD cord-014516-r59usk02 1200 33 be be VB cord-014516-r59usk02 1200 34 expected expect VBN cord-014516-r59usk02 1200 35 to to TO cord-014516-r59usk02 1200 36 correlate correlate VB cord-014516-r59usk02 1200 37 with with IN cord-014516-r59usk02 1200 38 the the DT cord-014516-r59usk02 1200 39 presence presence NN cord-014516-r59usk02 1200 40 of of IN cord-014516-r59usk02 1200 41 renal renal JJ cord-014516-r59usk02 1200 42 tubular tubular JJ cord-014516-r59usk02 1200 43 damage damage NN cord-014516-r59usk02 1200 44 and and CC cord-014516-r59usk02 1200 45 CKD CKD NNP cord-014516-r59usk02 1200 46 . . . cord-014516-r59usk02 1201 1 The the DT cord-014516-r59usk02 1201 2 aim aim NN cord-014516-r59usk02 1201 3 of of IN cord-014516-r59usk02 1201 4 this this DT cord-014516-r59usk02 1201 5 study study NN cord-014516-r59usk02 1201 6 was be VBD cord-014516-r59usk02 1201 7 to to TO cord-014516-r59usk02 1201 8 establish establish VB cord-014516-r59usk02 1201 9 biological biological JJ cord-014516-r59usk02 1201 10 validity validity NN cord-014516-r59usk02 1201 11 of of IN cord-014516-r59usk02 1201 12 two two CD cord-014516-r59usk02 1201 13 particle particle NN cord-014516-r59usk02 1201 14 enhanced enhance VBN cord-014516-r59usk02 1201 15 turbidimetric turbidimetric JJ cord-014516-r59usk02 1201 16 assays assay NNS cord-014516-r59usk02 1201 17 ( ( -LRB- cord-014516-r59usk02 1201 18 PETIAs petia NNS cord-014516-r59usk02 1201 19 ) ) -RRB- cord-014516-r59usk02 1201 20 for for IN cord-014516-r59usk02 1201 21 the the DT cord-014516-r59usk02 1201 22 measurement measurement NN cord-014516-r59usk02 1201 23 of of IN cord-014516-r59usk02 1201 24 albumin albumin NN cord-014516-r59usk02 1201 25 and and CC cord-014516-r59usk02 1201 26 cystatin cystatin NNP cord-014516-r59usk02 1201 27 C C NNP cord-014516-r59usk02 1201 28 ( ( -LRB- cord-014516-r59usk02 1201 29 previously previously RB cord-014516-r59usk02 1201 30 validated validate VBN cord-014516-r59usk02 1201 31 for for IN cord-014516-r59usk02 1201 32 use use NN cord-014516-r59usk02 1201 33 in in IN cord-014516-r59usk02 1201 34 feline feline JJ cord-014516-r59usk02 1201 35 urine urine NN cord-014516-r59usk02 1201 36 ) ) -RRB- cord-014516-r59usk02 1201 37 by by IN cord-014516-r59usk02 1201 38 comparing compare VBG cord-014516-r59usk02 1201 39 the the DT cord-014516-r59usk02 1201 40 UAC UAC NNP cord-014516-r59usk02 1201 41 and and CC cord-014516-r59usk02 1201 42 UCysC UCysC NNP cord-014516-r59usk02 1201 43 between between IN cord-014516-r59usk02 1201 44 non non JJ cord-014516-r59usk02 1201 45 - - JJ cord-014516-r59usk02 1201 46 azotaemic azotaemic JJ cord-014516-r59usk02 1201 47 cats cat NNS cord-014516-r59usk02 1201 48 and and CC cord-014516-r59usk02 1201 49 cats cat NNS cord-014516-r59usk02 1201 50 with with IN cord-014516-r59usk02 1201 51 azotaemic azotaemic JJ cord-014516-r59usk02 1201 52 CKD CKD NNP cord-014516-r59usk02 1201 53 . . . cord-014516-r59usk02 1202 1 Blood blood NN cord-014516-r59usk02 1202 2 and and CC cord-014516-r59usk02 1202 3 urine urine NN cord-014516-r59usk02 1202 4 samples sample NNS cord-014516-r59usk02 1202 5 were be VBD cord-014516-r59usk02 1202 6 obtained obtain VBN cord-014516-r59usk02 1202 7 from from IN cord-014516-r59usk02 1202 8 cats cat NNS cord-014516-r59usk02 1202 9 at at IN cord-014516-r59usk02 1202 10 three three CD cord-014516-r59usk02 1202 11 UK UK NNP cord-014516-r59usk02 1202 12 first first JJ cord-014516-r59usk02 1202 13 opinion opinion NN cord-014516-r59usk02 1202 14 practices practice NNS cord-014516-r59usk02 1202 15 as as IN cord-014516-r59usk02 1202 16 part part NN cord-014516-r59usk02 1202 17 of of IN cord-014516-r59usk02 1202 18 a a DT cord-014516-r59usk02 1202 19 geriatric geriatric JJ cord-014516-r59usk02 1202 20 screening screening NN cord-014516-r59usk02 1202 21 programme programme NN cord-014516-r59usk02 1202 22 . . . cord-014516-r59usk02 1203 1 Haematology Haematology NNP cord-014516-r59usk02 1203 2 , , , cord-014516-r59usk02 1203 3 serum serum NN cord-014516-r59usk02 1203 4 biochemistry biochemistry NN cord-014516-r59usk02 1203 5 ( ( -LRB- cord-014516-r59usk02 1203 6 including include VBG cord-014516-r59usk02 1203 7 total total JJ cord-014516-r59usk02 1203 8 thyroxine thyroxine JJ cord-014516-r59usk02 1203 9 concentration concentration NN cord-014516-r59usk02 1203 10 ( ( -LRB- cord-014516-r59usk02 1203 11 TT4 TT4 NNP cord-014516-r59usk02 1203 12 ) ) -RRB- cord-014516-r59usk02 1203 13 ) ) -RRB- cord-014516-r59usk02 1203 14 and and CC cord-014516-r59usk02 1203 15 urinalysis urinalysis NN cord-014516-r59usk02 1203 16 ( ( -LRB- cord-014516-r59usk02 1203 17 including include VBG cord-014516-r59usk02 1203 18 urine urine NN cord-014516-r59usk02 1203 19 protein protein NN cord-014516-r59usk02 1203 20 : : : cord-014516-r59usk02 1203 21 creati creati VB cord-014516-r59usk02 1203 22 - - HYPH cord-014516-r59usk02 1203 23 nine nine CD cord-014516-r59usk02 1203 24 ratio ratio NN cord-014516-r59usk02 1203 25 ( ( -LRB- cord-014516-r59usk02 1203 26 UPC UPC NNP cord-014516-r59usk02 1203 27 ) ) -RRB- cord-014516-r59usk02 1203 28 ) ) -RRB- cord-014516-r59usk02 1203 29 were be VBD cord-014516-r59usk02 1203 30 performed perform VBN cord-014516-r59usk02 1203 31 . . . cord-014516-r59usk02 1204 1 Dental dental JJ cord-014516-r59usk02 1204 2 disease disease NN cord-014516-r59usk02 1204 3 score score NN cord-014516-r59usk02 1204 4 ( ( -LRB- cord-014516-r59usk02 1204 5 calculus calculus NN cord-014516-r59usk02 1204 6 and and CC cord-014516-r59usk02 1204 7 gingivitis gingivitis NN cord-014516-r59usk02 1204 8 ) ) -RRB- cord-014516-r59usk02 1204 9 and and CC cord-014516-r59usk02 1204 10 body body NN cord-014516-r59usk02 1204 11 condition condition NN cord-014516-r59usk02 1204 12 score score NN cord-014516-r59usk02 1204 13 ( ( -LRB- cord-014516-r59usk02 1204 14 BCS BCS NNP cord-014516-r59usk02 1204 15 ) ) -RRB- cord-014516-r59usk02 1204 16 were be VBD cord-014516-r59usk02 1204 17 recorded record VBN cord-014516-r59usk02 1204 18 . . . cord-014516-r59usk02 1205 1 Cats cat NNS cord-014516-r59usk02 1205 2 with with IN cord-014516-r59usk02 1205 3 TT4 TT4 NNP cord-014516-r59usk02 1205 4 > > XX cord-014516-r59usk02 1205 5 40 40 CD cord-014516-r59usk02 1205 6 nmol nmol NNP cord-014516-r59usk02 1205 7 / / SYM cord-014516-r59usk02 1205 8 L l NN cord-014516-r59usk02 1205 9 , , , cord-014516-r59usk02 1205 10 evidence evidence NN cord-014516-r59usk02 1205 11 of of IN cord-014516-r59usk02 1205 12 pyuria pyuria NNS cord-014516-r59usk02 1205 13 or or CC cord-014516-r59usk02 1205 14 bacteruria bacteruria NNP cord-014516-r59usk02 1205 15 , , , cord-014516-r59usk02 1205 16 or or CC cord-014516-r59usk02 1205 17 significant significant JJ cord-014516-r59usk02 1205 18 systemic systemic JJ cord-014516-r59usk02 1205 19 disease disease NN cord-014516-r59usk02 1205 20 were be VBD cord-014516-r59usk02 1205 21 excluded exclude VBN cord-014516-r59usk02 1205 22 . . . cord-014516-r59usk02 1206 1 UAC UAC NNP cord-014516-r59usk02 1206 2 and and CC cord-014516-r59usk02 1206 3 UCysC UCysC NNP cord-014516-r59usk02 1206 4 were be VBD cord-014516-r59usk02 1206 5 determined determine VBN cord-014516-r59usk02 1206 6 in in IN cord-014516-r59usk02 1206 7 non non JJ cord-014516-r59usk02 1206 8 - - JJ cord-014516-r59usk02 1206 9 azotaemic azotaemic JJ cord-014516-r59usk02 1206 10 cats cat NNS cord-014516-r59usk02 1206 11 ( ( -LRB- cord-014516-r59usk02 1206 12 n n NN cord-014516-r59usk02 1206 13 = = SYM cord-014516-r59usk02 1206 14 50 50 CD cord-014516-r59usk02 1206 15 ) ) -RRB- cord-014516-r59usk02 1206 16 and and CC cord-014516-r59usk02 1206 17 cats cat NNS cord-014516-r59usk02 1206 18 with with IN cord-014516-r59usk02 1206 19 azotaemic azotaemic NNP cord-014516-r59usk02 1206 20 CKD CKD NNP cord-014516-r59usk02 1206 21 ( ( -LRB- cord-014516-r59usk02 1206 22 n n NN cord-014516-r59usk02 1206 23 = = SYM cord-014516-r59usk02 1206 24 10 10 CD cord-014516-r59usk02 1206 25 , , , cord-014516-r59usk02 1206 26 defined define VBN cord-014516-r59usk02 1206 27 as as IN cord-014516-r59usk02 1206 28 a a DT cord-014516-r59usk02 1206 29 serum serum NN cord-014516-r59usk02 1206 30 creatinine creatinine NN cord-014516-r59usk02 1206 31 concentration concentration NN cord-014516-r59usk02 1206 32 > > XX cord-014516-r59usk02 1207 1 153 153 CD cord-014516-r59usk02 1207 2 lmol lmol NNP cord-014516-r59usk02 1207 3 / / SYM cord-014516-r59usk02 1207 4 L l NN cord-014516-r59usk02 1207 5 and and CC cord-014516-r59usk02 1207 6 concurrent concurrent JJ cord-014516-r59usk02 1207 7 urine urine NN cord-014516-r59usk02 1207 8 specific specific JJ cord-014516-r59usk02 1207 9 gravity gravity NN cord-014516-r59usk02 1207 10 < < XX cord-014516-r59usk02 1207 11 1.035 1.035 CD cord-014516-r59usk02 1207 12 ) ) -RRB- cord-014516-r59usk02 1207 13 . . . cord-014516-r59usk02 1208 1 Comparisons comparison NNS cord-014516-r59usk02 1208 2 between between IN cord-014516-r59usk02 1208 3 the the DT cord-014516-r59usk02 1208 4 non non JJ cord-014516-r59usk02 1208 5 - - JJ cord-014516-r59usk02 1208 6 azotaemic azotaemic JJ cord-014516-r59usk02 1208 7 and and CC cord-014516-r59usk02 1208 8 azotaemic azotaemic JJ cord-014516-r59usk02 1208 9 CKD CKD NNP cord-014516-r59usk02 1208 10 groups group NNS cord-014516-r59usk02 1208 11 were be VBD cord-014516-r59usk02 1208 12 made make VBN cord-014516-r59usk02 1208 13 using use VBG cord-014516-r59usk02 1208 14 the the DT cord-014516-r59usk02 1208 15 Mann Mann NNP cord-014516-r59usk02 1208 16 Whitney Whitney NNP cord-014516-r59usk02 1208 17 U U NNP cord-014516-r59usk02 1208 18 test test NN cord-014516-r59usk02 1208 19 . . . cord-014516-r59usk02 1209 1 Correlations correlation NNS cord-014516-r59usk02 1209 2 were be VBD cord-014516-r59usk02 1209 3 assessed assess VBN cord-014516-r59usk02 1209 4 by by IN cord-014516-r59usk02 1209 5 Spearman Spearman NNP cord-014516-r59usk02 1209 6 's 's POS cord-014516-r59usk02 1209 7 correlation correlation NN cord-014516-r59usk02 1209 8 coefficient coefficient NN cord-014516-r59usk02 1209 9 . . . cord-014516-r59usk02 1210 1 Data datum NNS cord-014516-r59usk02 1210 2 are be VBP cord-014516-r59usk02 1210 3 presented present VBN cord-014516-r59usk02 1210 4 as as IN cord-014516-r59usk02 1210 5 median median JJ cord-014516-r59usk02 1210 6 [ [ -LRB- cord-014516-r59usk02 1210 7 25 25 CD cord-014516-r59usk02 1210 8 th th XX cord-014516-r59usk02 1210 9 , , , cord-014516-r59usk02 1210 10 75 75 CD cord-014516-r59usk02 1210 11 th th XX cord-014516-r59usk02 1210 12 percentile percentile NN cord-014516-r59usk02 1210 13 ] ] -RRB- cord-014516-r59usk02 1210 14 and and CC cord-014516-r59usk02 1210 15 statistical statistical JJ cord-014516-r59usk02 1210 16 significance significance NN cord-014516-r59usk02 1210 17 was be VBD cord-014516-r59usk02 1210 18 defined define VBN cord-014516-r59usk02 1210 19 as as IN cord-014516-r59usk02 1210 20 P p NN cord-014516-r59usk02 1210 21 < < XX cord-014516-r59usk02 1210 22 0.05 0.05 CD cord-014516-r59usk02 1210 23 . . . cord-014516-r59usk02 1211 1 UAC UAC NNP cord-014516-r59usk02 1211 2 was be VBD cord-014516-r59usk02 1211 3 significantly significantly RB cord-014516-r59usk02 1211 4 higher high JJR cord-014516-r59usk02 1211 5 in in IN cord-014516-r59usk02 1211 6 the the DT cord-014516-r59usk02 1211 7 azotaemic azotaemic NNP cord-014516-r59usk02 1211 8 group group NN cord-014516-r59usk02 1211 9 than than IN cord-014516-r59usk02 1211 10 the the DT cord-014516-r59usk02 1211 11 non non JJ cord-014516-r59usk02 1211 12 - - JJ cord-014516-r59usk02 1211 13 azotaemic azotaemic JJ cord-014516-r59usk02 1211 14 group group NN cord-014516-r59usk02 1211 15 ( ( -LRB- cord-014516-r59usk02 1211 16 31.5 31.5 CD cord-014516-r59usk02 1211 17 [ [ -LRB- cord-014516-r59usk02 1211 18 9.8 9.8 CD cord-014516-r59usk02 1211 19 , , , cord-014516-r59usk02 1211 20 97 97 CD cord-014516-r59usk02 1211 21 .6]x10 .6]x10 . cord-014516-r59usk02 1212 1 -3 -3 NNP cord-014516-r59usk02 1213 1 vs. vs. FW cord-014516-r59usk02 1213 2 11.6 11.6 CD cord-014516-r59usk02 1213 3 [ [ -LRB- cord-014516-r59usk02 1213 4 6.4 6.4 CD cord-014516-r59usk02 1213 5 , , , cord-014516-r59usk02 1213 6 19.0]x10 19.0]x10 CD cord-014516-r59usk02 1213 7 -3 -3 NNP cord-014516-r59usk02 1213 8 ; ; : cord-014516-r59usk02 1213 9 P p NN cord-014516-r59usk02 1213 10 = = SYM cord-014516-r59usk02 1213 11 0.034 0.034 CD cord-014516-r59usk02 1213 12 ) ) -RRB- cord-014516-r59usk02 1213 13 , , , cord-014516-r59usk02 1213 14 whereas whereas IN cord-014516-r59usk02 1213 15 UPC UPC NNP cord-014516-r59usk02 1213 16 was be VBD cord-014516-r59usk02 1213 17 not not RB cord-014516-r59usk02 1213 18 significantly significantly RB cord-014516-r59usk02 1213 19 different different JJ cord-014516-r59usk02 1213 20 between between IN cord-014516-r59usk02 1213 21 the the DT cord-014516-r59usk02 1213 22 groups group NNS cord-014516-r59usk02 1213 23 ( ( -LRB- cord-014516-r59usk02 1213 24 P p NN cord-014516-r59usk02 1213 25 = = SYM cord-014516-r59usk02 1213 26 0.619 0.619 CD cord-014516-r59usk02 1213 27 ) ) -RRB- cord-014516-r59usk02 1213 28 . . . cord-014516-r59usk02 1214 1 Unexpectedly unexpectedly RB cord-014516-r59usk02 1214 2 , , , cord-014516-r59usk02 1214 3 UCysC UCysC NNP cord-014516-r59usk02 1214 4 tended tend VBD cord-014516-r59usk02 1214 5 to to TO cord-014516-r59usk02 1214 6 be be VB cord-014516-r59usk02 1214 7 lower low JJR cord-014516-r59usk02 1214 8 in in IN cord-014516-r59usk02 1214 9 azotaemic azotaemic JJ cord-014516-r59usk02 1214 10 cats cat NNS cord-014516-r59usk02 1214 11 than than IN cord-014516-r59usk02 1214 12 non non JJ cord-014516-r59usk02 1214 13 - - JJ cord-014516-r59usk02 1214 14 azotaemic azotaemic JJ cord-014516-r59usk02 1214 15 cats cat NNS cord-014516-r59usk02 1214 16 ( ( -LRB- cord-014516-r59usk02 1214 17 3.2 3.2 CD cord-014516-r59usk02 1214 18 [ [ -LRB- cord-014516-r59usk02 1214 19 1.5 1.5 CD cord-014516-r59usk02 1214 20 , , , cord-014516-r59usk02 1214 21 9.1]x10 9.1]x10 CD cord-014516-r59usk02 1214 22 -6 -6 NNP cord-014516-r59usk02 1215 1 vs. vs. FW cord-014516-r59usk02 1215 2 11.8 11.8 CD cord-014516-r59usk02 1215 3 [ [ -LRB- cord-014516-r59usk02 1215 4 4.4 4.4 CD cord-014516-r59usk02 1215 5 , , , cord-014516-r59usk02 1215 6 23.2]x10 23.2]x10 CD cord-014516-r59usk02 1215 7 -6 -6 NN cord-014516-r59usk02 1215 8 ; ; : cord-014516-r59usk02 1215 9 P p NN cord-014516-r59usk02 1215 10 = = SYM cord-014516-r59usk02 1215 11 0.071 0.071 CD cord-014516-r59usk02 1215 12 ) ) -RRB- cord-014516-r59usk02 1215 13 . . . cord-014516-r59usk02 1216 1 UAC UAC NNP cord-014516-r59usk02 1216 2 was be VBD cord-014516-r59usk02 1216 3 weakly weakly RB cord-014516-r59usk02 1216 4 positively positively RB cord-014516-r59usk02 1216 5 correlated correlate VBN cord-014516-r59usk02 1216 6 with with IN cord-014516-r59usk02 1216 7 serum serum NN cord-014516-r59usk02 1216 8 urea urea NN cord-014516-r59usk02 1216 9 concentration concentration NN cord-014516-r59usk02 1216 10 ( ( -LRB- cord-014516-r59usk02 1216 11 r r NN cord-014516-r59usk02 1216 12 s s NN cord-014516-r59usk02 1216 13 = = SYM cord-014516-r59usk02 1216 14 0.327 0.327 CD cord-014516-r59usk02 1216 15 , , , cord-014516-r59usk02 1216 16 P p NN cord-014516-r59usk02 1216 17 = = SYM cord-014516-r59usk02 1216 18 0.011 0.011 CD cord-014516-r59usk02 1216 19 ) ) -RRB- cord-014516-r59usk02 1216 20 , , , cord-014516-r59usk02 1216 21 but but CC cord-014516-r59usk02 1216 22 was be VBD cord-014516-r59usk02 1216 23 not not RB cord-014516-r59usk02 1216 24 correlated correlate VBN cord-014516-r59usk02 1216 25 with with IN cord-014516-r59usk02 1216 26 serum serum NN cord-014516-r59usk02 1216 27 creatinine creatinine NN cord-014516-r59usk02 1216 28 concentration concentration NN cord-014516-r59usk02 1216 29 . . . cord-014516-r59usk02 1217 1 UCysC UCysC NNP cord-014516-r59usk02 1217 2 was be VBD cord-014516-r59usk02 1217 3 not not RB cord-014516-r59usk02 1217 4 significantly significantly RB cord-014516-r59usk02 1217 5 correlated correlate VBN cord-014516-r59usk02 1217 6 with with IN cord-014516-r59usk02 1217 7 serum serum NN cord-014516-r59usk02 1217 8 concentrations concentration NNS cord-014516-r59usk02 1217 9 of of IN cord-014516-r59usk02 1217 10 urea urea NN cord-014516-r59usk02 1217 11 , , , cord-014516-r59usk02 1217 12 creatinine creatinine NN cord-014516-r59usk02 1217 13 or or CC cord-014516-r59usk02 1217 14 TT4 TT4 NNP cord-014516-r59usk02 1217 15 . . . cord-014516-r59usk02 1218 1 UAC UAC NNP cord-014516-r59usk02 1218 2 was be VBD cord-014516-r59usk02 1218 3 also also RB cord-014516-r59usk02 1218 4 weakly weakly RB cord-014516-r59usk02 1218 5 negatively negatively RB cord-014516-r59usk02 1218 6 correlated correlate VBN cord-014516-r59usk02 1218 7 with with IN cord-014516-r59usk02 1218 8 dental dental JJ cord-014516-r59usk02 1218 9 calculus calculus NN cord-014516-r59usk02 1218 10 score score NN cord-014516-r59usk02 1218 11 ( ( -LRB- cord-014516-r59usk02 1218 12 r r NN cord-014516-r59usk02 1218 13 s s NN cord-014516-r59usk02 1218 14 = = NN cord-014516-r59usk02 1218 15 -0.307 -0.307 NN cord-014516-r59usk02 1218 16 ; ; : cord-014516-r59usk02 1218 17 P p NN cord-014516-r59usk02 1218 18 = = SYM cord-014516-r59usk02 1218 19 0.019 0.019 CD cord-014516-r59usk02 1218 20 ) ) -RRB- cord-014516-r59usk02 1218 21 and and CC cord-014516-r59usk02 1218 22 BCS BCS NNP cord-014516-r59usk02 1218 23 ( ( -LRB- cord-014516-r59usk02 1218 24 r r NNP cord-014516-r59usk02 1218 25 s s NN cord-014516-r59usk02 1218 26 = = SYM cord-014516-r59usk02 1218 27 -0.438 -0.438 XX cord-014516-r59usk02 1218 28 ; ; : cord-014516-r59usk02 1218 29 P p NN cord-014516-r59usk02 1218 30 = = SYM cord-014516-r59usk02 1218 31 0.001 0.001 CD cord-014516-r59usk02 1218 32 ) ) -RRB- cord-014516-r59usk02 1218 33 . . . cord-014516-r59usk02 1219 1 UAC UAC NNP cord-014516-r59usk02 1219 2 appears appear VBZ cord-014516-r59usk02 1219 3 to to TO cord-014516-r59usk02 1219 4 be be VB cord-014516-r59usk02 1219 5 a a DT cord-014516-r59usk02 1219 6 more more RBR cord-014516-r59usk02 1219 7 sensitive sensitive JJ cord-014516-r59usk02 1219 8 test test NN cord-014516-r59usk02 1219 9 for for IN cord-014516-r59usk02 1219 10 azotaemic azotaemic NNP cord-014516-r59usk02 1219 11 CKD CKD NNP cord-014516-r59usk02 1219 12 than than IN cord-014516-r59usk02 1219 13 UPC UPC NNP cord-014516-r59usk02 1219 14 , , , cord-014516-r59usk02 1219 15 however however RB cord-014516-r59usk02 1219 16 the the DT cord-014516-r59usk02 1219 17 apparent apparent JJ cord-014516-r59usk02 1219 18 low low JJ cord-014516-r59usk02 1219 19 specificity specificity NN cord-014516-r59usk02 1219 20 may may MD cord-014516-r59usk02 1219 21 limit limit VB cord-014516-r59usk02 1219 22 the the DT cord-014516-r59usk02 1219 23 utility utility NN cord-014516-r59usk02 1219 24 of of IN cord-014516-r59usk02 1219 25 UAC UAC NNP cord-014516-r59usk02 1219 26 as as IN cord-014516-r59usk02 1219 27 a a DT cord-014516-r59usk02 1219 28 urinary urinary JJ cord-014516-r59usk02 1219 29 screening screening NN cord-014516-r59usk02 1219 30 test test NN cord-014516-r59usk02 1219 31 for for IN cord-014516-r59usk02 1219 32 CKD CKD NNP cord-014516-r59usk02 1219 33 . . . cord-014516-r59usk02 1220 1 Increased increase VBN cord-014516-r59usk02 1220 2 UCysC UCysC NNP cord-014516-r59usk02 1220 3 ( ( -LRB- cord-014516-r59usk02 1220 4 determined determine VBN cord-014516-r59usk02 1220 5 by by IN cord-014516-r59usk02 1220 6 PETIA PETIA NNP cord-014516-r59usk02 1220 7 ) ) -RRB- cord-014516-r59usk02 1220 8 would would MD cord-014516-r59usk02 1220 9 not not RB cord-014516-r59usk02 1220 10 appear appear VB cord-014516-r59usk02 1220 11 to to TO cord-014516-r59usk02 1220 12 be be VB cord-014516-r59usk02 1220 13 a a DT cord-014516-r59usk02 1220 14 marker marker NN cord-014516-r59usk02 1220 15 of of IN cord-014516-r59usk02 1220 16 azotaemic azotaemic JJ cord-014516-r59usk02 1220 17 CKD CKD NNP cord-014516-r59usk02 1220 18 in in IN cord-014516-r59usk02 1220 19 cats cat NNS cord-014516-r59usk02 1220 20 . . . cord-014516-r59usk02 1221 1 No no DT cord-014516-r59usk02 1221 2 conflicts conflict NNS cord-014516-r59usk02 1221 3 of of IN cord-014516-r59usk02 1221 4 interest interest NN cord-014516-r59usk02 1221 5 reported report VBN cord-014516-r59usk02 1221 6 . . . cord-014516-r59usk02 1222 1 Cystinuria Cystinuria NNP cord-014516-r59usk02 1222 2 is be VBZ cord-014516-r59usk02 1222 3 an an DT cord-014516-r59usk02 1222 4 inherited inherit VBN cord-014516-r59usk02 1222 5 metabolic metabolic JJ cord-014516-r59usk02 1222 6 disorder disorder NN cord-014516-r59usk02 1222 7 that that WDT cord-014516-r59usk02 1222 8 causes cause VBZ cord-014516-r59usk02 1222 9 defective defective JJ cord-014516-r59usk02 1222 10 tubular tubular JJ cord-014516-r59usk02 1222 11 reabsorption reabsorption NN cord-014516-r59usk02 1222 12 of of IN cord-014516-r59usk02 1222 13 the the DT cord-014516-r59usk02 1222 14 aminoacids aminoacid NNS cord-014516-r59usk02 1222 15 cystine cystine NN cord-014516-r59usk02 1222 16 , , , cord-014516-r59usk02 1222 17 ornithine ornithine NN cord-014516-r59usk02 1222 18 , , , cord-014516-r59usk02 1222 19 lysine lysine NN cord-014516-r59usk02 1222 20 and and CC cord-014516-r59usk02 1222 21 arginine arginine NN cord-014516-r59usk02 1222 22 ( ( -LRB- cord-014516-r59usk02 1222 23 COLA COLA NNP cord-014516-r59usk02 1222 24 ) ) -RRB- cord-014516-r59usk02 1222 25 . . . cord-014516-r59usk02 1223 1 The the DT cord-014516-r59usk02 1223 2 low low JJ cord-014516-r59usk02 1223 3 solubility solubility NN cord-014516-r59usk02 1223 4 of of IN cord-014516-r59usk02 1223 5 cystine cystine NN cord-014516-r59usk02 1223 6 in in IN cord-014516-r59usk02 1223 7 acidic acidic JJ cord-014516-r59usk02 1223 8 urine urine NN cord-014516-r59usk02 1223 9 promotes promote VBZ cord-014516-r59usk02 1223 10 formation formation NN cord-014516-r59usk02 1223 11 of of IN cord-014516-r59usk02 1223 12 cystine cystine NN cord-014516-r59usk02 1223 13 crystals crystal NNS cord-014516-r59usk02 1223 14 and and CC cord-014516-r59usk02 1223 15 uroliths urolith NNS cord-014516-r59usk02 1223 16 in in IN cord-014516-r59usk02 1223 17 the the DT cord-014516-r59usk02 1223 18 urinary urinary JJ cord-014516-r59usk02 1223 19 tract tract NN cord-014516-r59usk02 1223 20 resulting result VBG cord-014516-r59usk02 1223 21 in in IN cord-014516-r59usk02 1223 22 the the DT cord-014516-r59usk02 1223 23 clinical clinical JJ cord-014516-r59usk02 1223 24 signs sign NNS cord-014516-r59usk02 1223 25 of of IN cord-014516-r59usk02 1223 26 stranguria stranguria NNP cord-014516-r59usk02 1223 27 , , , cord-014516-r59usk02 1223 28 urinary urinary JJ cord-014516-r59usk02 1223 29 obstruction obstruction NN cord-014516-r59usk02 1223 30 and and CC cord-014516-r59usk02 1223 31 renal renal JJ cord-014516-r59usk02 1223 32 failure failure NN cord-014516-r59usk02 1223 33 in in IN cord-014516-r59usk02 1223 34 affected affect VBN cord-014516-r59usk02 1223 35 individuals individual NNS cord-014516-r59usk02 1223 36 . . . cord-014516-r59usk02 1224 1 Cystinuria Cystinuria NNP cord-014516-r59usk02 1224 2 occurs occur VBZ cord-014516-r59usk02 1224 3 in in IN cord-014516-r59usk02 1224 4 > > $ cord-014516-r59usk02 1224 5 70 70 CD cord-014516-r59usk02 1224 6 breeds breed NNS cord-014516-r59usk02 1224 7 of of IN cord-014516-r59usk02 1224 8 dog dog NN cord-014516-r59usk02 1224 9 and and CC cord-014516-r59usk02 1224 10 has have VBZ cord-014516-r59usk02 1224 11 been be VBN cord-014516-r59usk02 1224 12 classified classify VBN cord-014516-r59usk02 1224 13 into into IN cord-014516-r59usk02 1224 14 types type NNS cord-014516-r59usk02 1224 15 IA IA NNP cord-014516-r59usk02 1224 16 ( ( -LRB- cord-014516-r59usk02 1224 17 Newfoundland Newfoundland NNP cord-014516-r59usk02 1224 18 , , , cord-014516-r59usk02 1224 19 Landseer Landseer NNP cord-014516-r59usk02 1224 20 , , , cord-014516-r59usk02 1224 21 Labrador Labrador NNP cord-014516-r59usk02 1224 22 ) ) -RRB- cord-014516-r59usk02 1224 23 , , , cord-014516-r59usk02 1224 24 IIA IIA NNP cord-014516-r59usk02 1224 25 ( ( -LRB- cord-014516-r59usk02 1224 26 Australian Australian NNP cord-014516-r59usk02 1224 27 Cattle Cattle NNP cord-014516-r59usk02 1224 28 dog dog NN cord-014516-r59usk02 1224 29 ) ) -RRB- cord-014516-r59usk02 1224 30 , , , cord-014516-r59usk02 1224 31 IB IB NNP cord-014516-r59usk02 1224 32 ( ( -LRB- cord-014516-r59usk02 1224 33 Miniature Miniature NNP cord-014516-r59usk02 1224 34 Pinscher Pinscher NNP cord-014516-r59usk02 1224 35 ) ) -RRB- cord-014516-r59usk02 1224 36 and and CC cord-014516-r59usk02 1224 37 III III NNP cord-014516-r59usk02 1224 38 ( ( -LRB- cord-014516-r59usk02 1224 39 androgen androgen NN cord-014516-r59usk02 1224 40 - - HYPH cord-014516-r59usk02 1224 41 dependent dependent JJ cord-014516-r59usk02 1224 42 ; ; : cord-014516-r59usk02 1224 43 e.g. e.g. RB cord-014516-r59usk02 1224 44 Mastiff mastiff NN cord-014516-r59usk02 1224 45 , , , cord-014516-r59usk02 1224 46 Irish Irish NNP cord-014516-r59usk02 1224 47 Terrier Terrier NNP cord-014516-r59usk02 1224 48 ) ) -RRB- cord-014516-r59usk02 1224 49 . . . cord-014516-r59usk02 1225 1 The the DT cord-014516-r59usk02 1225 2 Kromfohrl€ Kromfohrl€ NNP cord-014516-r59usk02 1225 3 ander ander NNP cord-014516-r59usk02 1225 4 is be VBZ cord-014516-r59usk02 1225 5 a a DT cord-014516-r59usk02 1225 6 medium medium JJ cord-014516-r59usk02 1225 7 - - HYPH cord-014516-r59usk02 1225 8 sized sized JJ cord-014516-r59usk02 1225 9 companion companion NN cord-014516-r59usk02 1225 10 dog dog NN cord-014516-r59usk02 1225 11 , , , cord-014516-r59usk02 1225 12 bred breed VBN cord-014516-r59usk02 1225 13 initially initially RB cord-014516-r59usk02 1225 14 as as IN cord-014516-r59usk02 1225 15 a a DT cord-014516-r59usk02 1225 16 cross cross NN cord-014516-r59usk02 1225 17 between between IN cord-014516-r59usk02 1225 18 a a DT cord-014516-r59usk02 1225 19 Wire Wire NNP cord-014516-r59usk02 1225 20 Fox Fox NNP cord-014516-r59usk02 1225 21 Terrier Terrier NNP cord-014516-r59usk02 1225 22 and and CC cord-014516-r59usk02 1225 23 a a DT cord-014516-r59usk02 1225 24 Grand Grand NNP cord-014516-r59usk02 1225 25 Griffon Griffon NNP cord-014516-r59usk02 1225 26 Vend vend NN cord-014516-r59usk02 1225 27 een een NN cord-014516-r59usk02 1225 28 , , , cord-014516-r59usk02 1225 29 first first RB cord-014516-r59usk02 1225 30 recognised recognise VBN cord-014516-r59usk02 1225 31 internationally internationally RB cord-014516-r59usk02 1225 32 in1955 in1955 NNP cord-014516-r59usk02 1225 33 . . . cord-014516-r59usk02 1226 1 Cystinuria Cystinuria NNP cord-014516-r59usk02 1226 2 has have VBZ cord-014516-r59usk02 1226 3 been be VBN cord-014516-r59usk02 1226 4 suspected suspect VBN cord-014516-r59usk02 1226 5 in in IN cord-014516-r59usk02 1226 6 this this DT cord-014516-r59usk02 1226 7 breed breed NN cord-014516-r59usk02 1226 8 but but CC cord-014516-r59usk02 1226 9 no no DT cord-014516-r59usk02 1226 10 cases case NNS cord-014516-r59usk02 1226 11 have have VBP cord-014516-r59usk02 1226 12 been be VBN cord-014516-r59usk02 1226 13 reported report VBN cord-014516-r59usk02 1226 14 in in IN cord-014516-r59usk02 1226 15 the the DT cord-014516-r59usk02 1226 16 literature literature NN cord-014516-r59usk02 1226 17 to to IN cord-014516-r59usk02 1226 18 date date NN cord-014516-r59usk02 1226 19 . . . cord-014516-r59usk02 1227 1 We -PRON- PRP cord-014516-r59usk02 1227 2 determined determine VBD cord-014516-r59usk02 1227 3 urinary urinary JJ cord-014516-r59usk02 1227 4 COLA COLA NNP cord-014516-r59usk02 1227 5 concentrations concentration NNS cord-014516-r59usk02 1227 6 in in IN cord-014516-r59usk02 1227 7 81 81 CD cord-014516-r59usk02 1227 8 adult adult NN cord-014516-r59usk02 1227 9 Kro Kro NNP cord-014516-r59usk02 1227 10 - - HYPH cord-014516-r59usk02 1227 11 mfohrl€ mfohrl€ NNP cord-014516-r59usk02 1227 12 ander ander NNP cord-014516-r59usk02 1227 13 dogs dog NNS cord-014516-r59usk02 1227 14 aged age VBN cord-014516-r59usk02 1227 15 1 1 CD cord-014516-r59usk02 1227 16 - - SYM cord-014516-r59usk02 1227 17 10 10 CD cord-014516-r59usk02 1227 18 years year NNS cord-014516-r59usk02 1227 19 comprising comprise VBG cord-014516-r59usk02 1227 20 48 48 CD cord-014516-r59usk02 1227 21 intact intact JJ cord-014516-r59usk02 1227 22 and and CC cord-014516-r59usk02 1227 23 6 6 CD cord-014516-r59usk02 1227 24 castrated castrate VBN cord-014516-r59usk02 1227 25 males male NNS cord-014516-r59usk02 1227 26 , , , cord-014516-r59usk02 1227 27 and and CC cord-014516-r59usk02 1227 28 26 26 CD cord-014516-r59usk02 1227 29 intact intact JJ cord-014516-r59usk02 1227 30 and and CC cord-014516-r59usk02 1227 31 1 1 CD cord-014516-r59usk02 1227 32 spayed spay VBN cord-014516-r59usk02 1227 33 females female NNS cord-014516-r59usk02 1227 34 . . . cord-014516-r59usk02 1228 1 A a DT cord-014516-r59usk02 1228 2 total total NN cord-014516-r59usk02 1228 3 of of IN cord-014516-r59usk02 1228 4 15 15 CD cord-014516-r59usk02 1228 5 ( ( -LRB- cord-014516-r59usk02 1228 6 31 31 CD cord-014516-r59usk02 1228 7 % % NN cord-014516-r59usk02 1228 8 ) ) -RRB- cord-014516-r59usk02 1228 9 intact intact JJ cord-014516-r59usk02 1228 10 males male NNS cord-014516-r59usk02 1228 11 aged age VBN cord-014516-r59usk02 1228 12 1.5 1.5 CD cord-014516-r59usk02 1228 13 to to TO cord-014516-r59usk02 1228 14 8.5 8.5 CD cord-014516-r59usk02 1228 15 years year NNS cord-014516-r59usk02 1228 16 had have VBD cord-014516-r59usk02 1228 17 COLA COLA NNP cord-014516-r59usk02 1228 18 values value NNS cord-014516-r59usk02 1229 1 > > XX cord-014516-r59usk02 1230 1 700 700 CD cord-014516-r59usk02 1230 2 lmol/ lmol/ CD cord-014516-r59usk02 1231 1 g g NNP cord-014516-r59usk02 1231 2 creatinine creatinine NN cord-014516-r59usk02 1231 3 and and CC cord-014516-r59usk02 1231 4 several several JJ cord-014516-r59usk02 1231 5 developed develop VBN cord-014516-r59usk02 1231 6 cystic cystic JJ cord-014516-r59usk02 1231 7 calculi calculus NNS cord-014516-r59usk02 1231 8 . . . cord-014516-r59usk02 1232 1 Furthermore furthermore RB cord-014516-r59usk02 1232 2 , , , cord-014516-r59usk02 1232 3 9 9 CD cord-014516-r59usk02 1232 4 intact intact JJ cord-014516-r59usk02 1232 5 male male JJ cord-014516-r59usk02 1232 6 dogs dog NNS cord-014516-r59usk02 1232 7 had have VBD cord-014516-r59usk02 1232 8 increased increase VBN cord-014516-r59usk02 1232 9 COLA COLA NNP cord-014516-r59usk02 1232 10 but but CC cord-014516-r59usk02 1232 11 normal normal JJ cord-014516-r59usk02 1232 12 cystine cystine NN cord-014516-r59usk02 1232 13 levels level NNS cord-014516-r59usk02 1232 14 . . . cord-014516-r59usk02 1233 1 All all DT cord-014516-r59usk02 1233 2 castrated castrate VBN cord-014516-r59usk02 1233 3 males male NNS cord-014516-r59usk02 1233 4 had have VBD cord-014516-r59usk02 1233 5 normal normal JJ cord-014516-r59usk02 1233 6 COLA COLA NNP cord-014516-r59usk02 1233 7 concentrations concentration NNS cord-014516-r59usk02 1233 8 . . . cord-014516-r59usk02 1234 1 No no DT cord-014516-r59usk02 1234 2 females female NNS cord-014516-r59usk02 1234 3 had have VBD cord-014516-r59usk02 1234 4 increased increase VBN cord-014516-r59usk02 1234 5 COLA COLA NNP cord-014516-r59usk02 1234 6 and and CC cord-014516-r59usk02 1234 7 cystine cystine NN cord-014516-r59usk02 1234 8 concentrations concentration NNS cord-014516-r59usk02 1234 9 or or CC cord-014516-r59usk02 1234 10 formed form VBD cord-014516-r59usk02 1234 11 any any DT cord-014516-r59usk02 1234 12 cystine cystine NN cord-014516-r59usk02 1234 13 calculi calculus NNS cord-014516-r59usk02 1234 14 . . . cord-014516-r59usk02 1235 1 We -PRON- PRP cord-014516-r59usk02 1235 2 conclude conclude VBP cord-014516-r59usk02 1235 3 that that IN cord-014516-r59usk02 1235 4 cystinuria cystinuria FW cord-014516-r59usk02 1235 5 with with IN cord-014516-r59usk02 1235 6 cystine cystine NN cord-014516-r59usk02 1235 7 calculi calculus NNS cord-014516-r59usk02 1235 8 occurs occur VBZ cord-014516-r59usk02 1235 9 frequently frequently RB cord-014516-r59usk02 1235 10 in in IN cord-014516-r59usk02 1235 11 adult adult NN cord-014516-r59usk02 1235 12 intact intact JJ cord-014516-r59usk02 1235 13 male male NN cord-014516-r59usk02 1235 14 Kromfohrl€ Kromfohrl€ NNP cord-014516-r59usk02 1235 15 ander ander NNP cord-014516-r59usk02 1235 16 dogs dog NNS cord-014516-r59usk02 1235 17 but but CC cord-014516-r59usk02 1235 18 neither neither DT cord-014516-r59usk02 1235 19 is be VBZ cord-014516-r59usk02 1235 20 seen see VBN cord-014516-r59usk02 1235 21 in in IN cord-014516-r59usk02 1235 22 females female NNS cord-014516-r59usk02 1235 23 . . . cord-014516-r59usk02 1236 1 This this DT cord-014516-r59usk02 1236 2 appears appear VBZ cord-014516-r59usk02 1236 3 to to TO cord-014516-r59usk02 1236 4 be be VB cord-014516-r59usk02 1236 5 an an DT cord-014516-r59usk02 1236 6 androgen androgen NN cord-014516-r59usk02 1236 7 dependent dependent JJ cord-014516-r59usk02 1236 8 type type NN cord-014516-r59usk02 1236 9 III iii CD cord-014516-r59usk02 1236 10 cystinuria cystinuria NNS cord-014516-r59usk02 1236 11 , , , cord-014516-r59usk02 1236 12 as as IN cord-014516-r59usk02 1236 13 seen see VBN cord-014516-r59usk02 1236 14 in in IN cord-014516-r59usk02 1236 15 Mastiff mastiff NN cord-014516-r59usk02 1236 16 - - HYPH cord-014516-r59usk02 1236 17 type type NN cord-014516-r59usk02 1236 18 dogs dog NNS cord-014516-r59usk02 1236 19 and and CC cord-014516-r59usk02 1236 20 Irish irish JJ cord-014516-r59usk02 1236 21 Terriers terrier NNS cord-014516-r59usk02 1236 22 . . . cord-014516-r59usk02 1237 1 Thus thus RB cord-014516-r59usk02 1237 2 , , , cord-014516-r59usk02 1237 3 castration castration NN cord-014516-r59usk02 1237 4 may may MD cord-014516-r59usk02 1237 5 resolve resolve VB cord-014516-r59usk02 1237 6 the the DT cord-014516-r59usk02 1237 7 increased increased JJ cord-014516-r59usk02 1237 8 urinary urinary JJ cord-014516-r59usk02 1237 9 COLA COLA NNP cord-014516-r59usk02 1237 10 excretion excretion NN cord-014516-r59usk02 1237 11 and and CC cord-014516-r59usk02 1237 12 risk risk NN cord-014516-r59usk02 1237 13 for for IN cord-014516-r59usk02 1237 14 cystine cystine NN cord-014516-r59usk02 1237 15 calculi calculus NNS cord-014516-r59usk02 1237 16 formation formation NN cord-014516-r59usk02 1237 17 and and CC cord-014516-r59usk02 1237 18 obstruction obstruction NN cord-014516-r59usk02 1237 19 . . . cord-014516-r59usk02 1238 1 The the DT cord-014516-r59usk02 1238 2 precise precise JJ cord-014516-r59usk02 1238 3 mode mode NN cord-014516-r59usk02 1238 4 of of IN cord-014516-r59usk02 1238 5 inheritance inheritance NN cord-014516-r59usk02 1238 6 is be VBZ cord-014516-r59usk02 1238 7 still still RB cord-014516-r59usk02 1238 8 unclear unclear JJ cord-014516-r59usk02 1238 9 . . . cord-014516-r59usk02 1239 1 All all DT cord-014516-r59usk02 1239 2 adult adult NN cord-014516-r59usk02 1239 3 intact intact JJ cord-014516-r59usk02 1239 4 male male NN cord-014516-r59usk02 1239 5 Kromfohrl€ Kromfohrl€ NNP cord-014516-r59usk02 1239 6 ander ander NNP cord-014516-r59usk02 1239 7 dogs dog NNS cord-014516-r59usk02 1239 8 should should MD cord-014516-r59usk02 1239 9 be be VB cord-014516-r59usk02 1239 10 screened screen VBN cord-014516-r59usk02 1239 11 by by IN cord-014516-r59usk02 1239 12 urinary urinary JJ cord-014516-r59usk02 1239 13 COLA COLA NNP cord-014516-r59usk02 1239 14 testing testing NN cord-014516-r59usk02 1239 15 . . . cord-014516-r59usk02 1240 1 Work work NN cord-014516-r59usk02 1240 2 carried carry VBD cord-014516-r59usk02 1240 3 out out RP cord-014516-r59usk02 1240 4 at at IN cord-014516-r59usk02 1240 5 the the DT cord-014516-r59usk02 1240 6 author author NN cord-014516-r59usk02 1240 7 's 's POS cord-014516-r59usk02 1240 8 previous previous JJ cord-014516-r59usk02 1240 9 place place NN cord-014516-r59usk02 1240 10 of of IN cord-014516-r59usk02 1240 11 employment employment NN cord-014516-r59usk02 1240 12 ( ( -LRB- cord-014516-r59usk02 1240 13 University University NNP cord-014516-r59usk02 1240 14 Children Children NNPS cord-014516-r59usk02 1240 15 's 's POS cord-014516-r59usk02 1240 16 Hospital Hospital NNP cord-014516-r59usk02 1240 17 , , , cord-014516-r59usk02 1240 18 Frankfurt Frankfurt NNP cord-014516-r59usk02 1240 19 , , , cord-014516-r59usk02 1240 20 Germany Germany NNP cord-014516-r59usk02 1240 21 ) ) -RRB- cord-014516-r59usk02 1240 22 . . . cord-014516-r59usk02 1241 1 ACS ACS NNP cord-014516-r59usk02 1241 2 , , , cord-014516-r59usk02 1241 3 RK RK NNP cord-014516-r59usk02 1241 4 , , , cord-014516-r59usk02 1241 5 EM EM NNP cord-014516-r59usk02 1241 6 , , , cord-014516-r59usk02 1241 7 MD MD NNP cord-014516-r59usk02 1241 8 and and CC cord-014516-r59usk02 1241 9 UG UG NNP cord-014516-r59usk02 1241 10 provide provide VB cord-014516-r59usk02 1241 11 a a DT cord-014516-r59usk02 1241 12 diagnostic diagnostic JJ cord-014516-r59usk02 1241 13 service service NN cord-014516-r59usk02 1241 14 for for IN cord-014516-r59usk02 1241 15 cystinuria cystinuria NNS cord-014516-r59usk02 1241 16 and and CC cord-014516-r59usk02 1241 17 other other JJ cord-014516-r59usk02 1241 18 inborn inborn JJ cord-014516-r59usk02 1241 19 errors error NNS cord-014516-r59usk02 1241 20 of of IN cord-014516-r59usk02 1241 21 metabolism metabolism NN cord-014516-r59usk02 1241 22 in in IN cord-014516-r59usk02 1241 23 companion companion NN cord-014516-r59usk02 1241 24 animals animal NNS cord-014516-r59usk02 1241 25 . . . cord-014516-r59usk02 1242 1 Ureteral ureteral JJ cord-014516-r59usk02 1242 2 urolithiasis urolithiasis NN cord-014516-r59usk02 1242 3 is be VBZ cord-014516-r59usk02 1242 4 an an DT cord-014516-r59usk02 1242 5 emerging emerge VBG cord-014516-r59usk02 1242 6 medical medical JJ cord-014516-r59usk02 1242 7 concern concern NN cord-014516-r59usk02 1242 8 in in IN cord-014516-r59usk02 1242 9 cats cat NNS cord-014516-r59usk02 1242 10 . . . cord-014516-r59usk02 1243 1 There there EX cord-014516-r59usk02 1243 2 are be VBP cord-014516-r59usk02 1243 3 few few JJ cord-014516-r59usk02 1243 4 reports report NNS cord-014516-r59usk02 1243 5 on on IN cord-014516-r59usk02 1243 6 epidemiology epidemiology NN cord-014516-r59usk02 1243 7 , , , cord-014516-r59usk02 1243 8 diagnosis diagnosis NN cord-014516-r59usk02 1243 9 or or CC cord-014516-r59usk02 1243 10 medical medical JJ cord-014516-r59usk02 1243 11 management management NN cord-014516-r59usk02 1243 12 of of IN cord-014516-r59usk02 1243 13 ureteral ureteral JJ cord-014516-r59usk02 1243 14 calculi calculus NNS cord-014516-r59usk02 1243 15 in in IN cord-014516-r59usk02 1243 16 cats cat NNS cord-014516-r59usk02 1243 17 , , , cord-014516-r59usk02 1243 18 particularly particularly RB cord-014516-r59usk02 1243 19 in in IN cord-014516-r59usk02 1243 20 Europe Europe NNP cord-014516-r59usk02 1243 21 . . . cord-014516-r59usk02 1244 1 Cats cat NNS cord-014516-r59usk02 1244 2 diagnosed diagnose VBD cord-014516-r59usk02 1244 3 with with IN cord-014516-r59usk02 1244 4 ureteral ureteral JJ cord-014516-r59usk02 1244 5 urolithiasis urolithiasis NN cord-014516-r59usk02 1244 6 in in IN cord-014516-r59usk02 1244 7 the the DT cord-014516-r59usk02 1244 8 teaching teaching NN cord-014516-r59usk02 1244 9 hospital hospital NN cord-014516-r59usk02 1244 10 of of IN cord-014516-r59usk02 1244 11 the the DT cord-014516-r59usk02 1244 12 veterinary veterinary JJ cord-014516-r59usk02 1244 13 school school NN cord-014516-r59usk02 1244 14 of of IN cord-014516-r59usk02 1244 15 Alfort Alfort NNP cord-014516-r59usk02 1244 16 from from IN cord-014516-r59usk02 1244 17 2005 2005 CD cord-014516-r59usk02 1244 18 to to IN cord-014516-r59usk02 1244 19 2013 2013 CD cord-014516-r59usk02 1244 20 were be VBD cord-014516-r59usk02 1244 21 included include VBN cord-014516-r59usk02 1244 22 in in IN cord-014516-r59usk02 1244 23 this this DT cord-014516-r59usk02 1244 24 study study NN cord-014516-r59usk02 1244 25 . . . cord-014516-r59usk02 1245 1 Diagnosis diagnosis NN cord-014516-r59usk02 1245 2 was be VBD cord-014516-r59usk02 1245 3 confirmed confirm VBN cord-014516-r59usk02 1245 4 with with IN cord-014516-r59usk02 1245 5 radiographs radiograph NNS cord-014516-r59usk02 1245 6 , , , cord-014516-r59usk02 1245 7 ultrasound ultrasound NN cord-014516-r59usk02 1245 8 scan scan NN cord-014516-r59usk02 1245 9 and/or and/or CC cord-014516-r59usk02 1245 10 laparotomy laparotomy NN cord-014516-r59usk02 1245 11 . . . cord-014516-r59usk02 1246 1 Signalment signalment JJ cord-014516-r59usk02 1246 2 , , , cord-014516-r59usk02 1246 3 clinical clinical JJ cord-014516-r59usk02 1246 4 signs sign NNS cord-014516-r59usk02 1246 5 , , , cord-014516-r59usk02 1246 6 clinicopathologic clinicopathologic JJ cord-014516-r59usk02 1246 7 and and CC cord-014516-r59usk02 1246 8 diagnostic diagnostic JJ cord-014516-r59usk02 1246 9 imaging imaging NN cord-014516-r59usk02 1246 10 findings finding NNS cord-014516-r59usk02 1246 11 , , , cord-014516-r59usk02 1246 12 medical medical JJ cord-014516-r59usk02 1246 13 treatment treatment NN cord-014516-r59usk02 1246 14 and and CC cord-014516-r59usk02 1246 15 outcome outcome NN cord-014516-r59usk02 1246 16 were be VBD cord-014516-r59usk02 1246 17 recorded record VBN cord-014516-r59usk02 1246 18 . . . cord-014516-r59usk02 1247 1 Epidemiological epidemiological JJ cord-014516-r59usk02 1247 2 data datum NNS cord-014516-r59usk02 1247 3 were be VBD cord-014516-r59usk02 1247 4 compared compare VBN cord-014516-r59usk02 1247 5 to to IN cord-014516-r59usk02 1247 6 a a DT cord-014516-r59usk02 1247 7 reference reference NN cord-014516-r59usk02 1247 8 population population NN cord-014516-r59usk02 1247 9 of of IN cord-014516-r59usk02 1247 10 7600 7600 CD cord-014516-r59usk02 1247 11 cats cat NNS cord-014516-r59usk02 1247 12 . . . cord-014516-r59usk02 1248 1 Eighty eighty CD cord-014516-r59usk02 1248 2 three three CD cord-014516-r59usk02 1248 3 cats cat NNS cord-014516-r59usk02 1248 4 were be VBD cord-014516-r59usk02 1248 5 included include VBN cord-014516-r59usk02 1248 6 in in IN cord-014516-r59usk02 1248 7 the the DT cord-014516-r59usk02 1248 8 study study NN cord-014516-r59usk02 1248 9 . . . cord-014516-r59usk02 1249 1 The the DT cord-014516-r59usk02 1249 2 occurrence occurrence NN cord-014516-r59usk02 1249 3 of of IN cord-014516-r59usk02 1249 4 ureteral ureteral JJ cord-014516-r59usk02 1249 5 urolithiasis urolithiasis NN cord-014516-r59usk02 1249 6 was be VBD cord-014516-r59usk02 1249 7 significantly significantly RB cord-014516-r59usk02 1249 8 higher high JJR cord-014516-r59usk02 1249 9 in in IN cord-014516-r59usk02 1249 10 Birman Birman NNP cord-014516-r59usk02 1249 11 To to IN cord-014516-r59usk02 1249 12 the the DT cord-014516-r59usk02 1249 13 author author NN cord-014516-r59usk02 1249 14 knowledge knowledge NN cord-014516-r59usk02 1249 15 , , , cord-014516-r59usk02 1249 16 it -PRON- PRP cord-014516-r59usk02 1249 17 is be VBZ cord-014516-r59usk02 1249 18 the the DT cord-014516-r59usk02 1249 19 first first JJ cord-014516-r59usk02 1249 20 time time NN cord-014516-r59usk02 1249 21 that that IN cord-014516-r59usk02 1249 22 a a DT cord-014516-r59usk02 1249 23 higher high JJR cord-014516-r59usk02 1249 24 prevalence prevalence NN cord-014516-r59usk02 1249 25 of of IN cord-014516-r59usk02 1249 26 ureteral ureteral JJ cord-014516-r59usk02 1249 27 calculi calculus NNS cord-014516-r59usk02 1249 28 in in IN cord-014516-r59usk02 1249 29 Birman Birman NNP cord-014516-r59usk02 1249 30 cats cat NNS cord-014516-r59usk02 1249 31 is be VBZ cord-014516-r59usk02 1249 32 reported report VBN cord-014516-r59usk02 1249 33 in in IN cord-014516-r59usk02 1249 34 Europe Europe NNP cord-014516-r59usk02 1249 35 . . . cord-014516-r59usk02 1250 1 Spontaneous spontaneous JJ cord-014516-r59usk02 1250 2 elimination elimination NN cord-014516-r59usk02 1250 3 of of IN cord-014516-r59usk02 1250 4 calculus calculus NN cord-014516-r59usk02 1250 5 is be VBZ cord-014516-r59usk02 1250 6 associated associate VBN cord-014516-r59usk02 1250 7 with with IN cord-014516-r59usk02 1250 8 a a DT cord-014516-r59usk02 1250 9 small small JJ cord-014516-r59usk02 1250 10 size size NN cord-014516-r59usk02 1250 11 ( ( -LRB- cord-014516-r59usk02 1250 12 < < NNP cord-014516-r59usk02 1250 13 1.5 1.5 CD cord-014516-r59usk02 1250 14 mm mm NNS cord-014516-r59usk02 1250 15 ) ) -RRB- cord-014516-r59usk02 1250 16 . . . cord-014516-r59usk02 1251 1 If if IN cord-014516-r59usk02 1251 2 the the DT cord-014516-r59usk02 1251 3 size size NN cord-014516-r59usk02 1251 4 of of IN cord-014516-r59usk02 1251 5 calculi calculus NNS cord-014516-r59usk02 1251 6 tends tend VBZ cord-014516-r59usk02 1251 7 to to TO cord-014516-r59usk02 1251 8 be be VB cord-014516-r59usk02 1251 9 bigger big JJR cord-014516-r59usk02 1251 10 in in IN cord-014516-r59usk02 1251 11 cats cat NNS cord-014516-r59usk02 1251 12 with with IN cord-014516-r59usk02 1251 13 no no DT cord-014516-r59usk02 1251 14 improvement improvement NN cord-014516-r59usk02 1251 15 of of IN cord-014516-r59usk02 1251 16 renal renal JJ cord-014516-r59usk02 1251 17 function function NN cord-014516-r59usk02 1251 18 after after IN cord-014516-r59usk02 1251 19 medical medical JJ cord-014516-r59usk02 1251 20 treatment treatment NN cord-014516-r59usk02 1251 21 , , , cord-014516-r59usk02 1251 22 prospective prospective JJ cord-014516-r59usk02 1251 23 studies study NNS cord-014516-r59usk02 1251 24 are be VBP cord-014516-r59usk02 1251 25 still still RB cord-014516-r59usk02 1251 26 needed need VBN cord-014516-r59usk02 1251 27 to to TO cord-014516-r59usk02 1251 28 determine determine VB cord-014516-r59usk02 1251 29 the the DT cord-014516-r59usk02 1251 30 best good JJS cord-014516-r59usk02 1251 31 medical medical JJ cord-014516-r59usk02 1251 32 treatment treatment NN cord-014516-r59usk02 1251 33 . . . cord-014516-r59usk02 1252 1 No no DT cord-014516-r59usk02 1252 2 conflicts conflict NNS cord-014516-r59usk02 1252 3 of of IN cord-014516-r59usk02 1252 4 interest interest NN cord-014516-r59usk02 1252 5 reported report VBN cord-014516-r59usk02 1252 6 . . . cord-014516-r59usk02 1253 1 Feline feline JJ cord-014516-r59usk02 1253 2 immunodeficiency immunodeficiency NN cord-014516-r59usk02 1253 3 virus virus NN cord-014516-r59usk02 1253 4 ( ( -LRB- cord-014516-r59usk02 1253 5 FIV fiv NN cord-014516-r59usk02 1253 6 ) ) -RRB- cord-014516-r59usk02 1253 7 infection infection NN cord-014516-r59usk02 1253 8 has have VBZ cord-014516-r59usk02 1253 9 been be VBN cord-014516-r59usk02 1253 10 associated associate VBN cord-014516-r59usk02 1253 11 with with IN cord-014516-r59usk02 1253 12 kidney kidney NN cord-014516-r59usk02 1253 13 disease disease NN cord-014516-r59usk02 1253 14 , , , cord-014516-r59usk02 1253 15 mainly mainly RB cord-014516-r59usk02 1253 16 characterised characterise VBN cord-014516-r59usk02 1253 17 by by IN cord-014516-r59usk02 1253 18 an an DT cord-014516-r59usk02 1253 19 increased increase VBN cord-014516-r59usk02 1253 20 prevalence prevalence NN cord-014516-r59usk02 1253 21 of of IN cord-014516-r59usk02 1253 22 proteinuria proteinuria NN cord-014516-r59usk02 1253 23 in in IN cord-014516-r59usk02 1253 24 FIV fiv NN cord-014516-r59usk02 1253 25 - - HYPH cord-014516-r59usk02 1253 26 infected infect VBN cord-014516-r59usk02 1253 27 cats cat NNS cord-014516-r59usk02 1253 28 . . . cord-014516-r59usk02 1254 1 However however RB cord-014516-r59usk02 1254 2 , , , cord-014516-r59usk02 1254 3 studies study NNS cord-014516-r59usk02 1254 4 evaluating evaluate VBG cord-014516-r59usk02 1254 5 renal renal JJ cord-014516-r59usk02 1254 6 variables variable NNS cord-014516-r59usk02 1254 7 in in IN cord-014516-r59usk02 1254 8 FIV fiv NN cord-014516-r59usk02 1254 9 - - HYPH cord-014516-r59usk02 1254 10 positive positive JJ cord-014516-r59usk02 1254 11 cats cat NNS cord-014516-r59usk02 1254 12 are be VBP cord-014516-r59usk02 1254 13 scarce scarce JJ cord-014516-r59usk02 1254 14 . . . cord-014516-r59usk02 1255 1 Recently recently RB cord-014516-r59usk02 1255 2 , , , cord-014516-r59usk02 1255 3 a a DT cord-014516-r59usk02 1255 4 higher high JJR cord-014516-r59usk02 1255 5 systolic systolic JJ cord-014516-r59usk02 1255 6 blood blood NN cord-014516-r59usk02 1255 7 pressure pressure NN cord-014516-r59usk02 1255 8 ( ( -LRB- cord-014516-r59usk02 1255 9 SBP SBP NNP cord-014516-r59usk02 1255 10 ) ) -RRB- cord-014516-r59usk02 1255 11 was be VBD cord-014516-r59usk02 1255 12 reported report VBN cord-014516-r59usk02 1255 13 in in IN cord-014516-r59usk02 1255 14 a a DT cord-014516-r59usk02 1255 15 small small JJ cord-014516-r59usk02 1255 16 number number NN cord-014516-r59usk02 1255 17 of of IN cord-014516-r59usk02 1255 18 FIV fiv NN cord-014516-r59usk02 1255 19 - - HYPH cord-014516-r59usk02 1255 20 infected infect VBN cord-014516-r59usk02 1255 21 cats cat NNS cord-014516-r59usk02 1255 22 . . . cord-014516-r59usk02 1256 1 Hypertension hypertension NN cord-014516-r59usk02 1256 2 is be VBZ cord-014516-r59usk02 1256 3 an an DT cord-014516-r59usk02 1256 4 important important JJ cord-014516-r59usk02 1256 5 cause cause NN cord-014516-r59usk02 1256 6 of of IN cord-014516-r59usk02 1256 7 proteinuria proteinuria NN cord-014516-r59usk02 1256 8 and and CC cord-014516-r59usk02 1256 9 a a DT cord-014516-r59usk02 1256 10 frequent frequent JJ cord-014516-r59usk02 1256 11 cause cause NN cord-014516-r59usk02 1256 12 of of IN cord-014516-r59usk02 1256 13 renal renal JJ cord-014516-r59usk02 1256 14 disease disease NN cord-014516-r59usk02 1256 15 in in IN cord-014516-r59usk02 1256 16 human human JJ cord-014516-r59usk02 1256 17 immunodeficiency immunodeficiency NN cord-014516-r59usk02 1256 18 virus virus NN cord-014516-r59usk02 1256 19 ( ( -LRB- cord-014516-r59usk02 1256 20 HIV HIV NNP cord-014516-r59usk02 1256 21 ) ) -RRB- cord-014516-r59usk02 1256 22 positive positive JJ cord-014516-r59usk02 1256 23 patients patient NNS cord-014516-r59usk02 1256 24 . . . cord-014516-r59usk02 1257 1 Therefore therefore RB cord-014516-r59usk02 1257 2 , , , cord-014516-r59usk02 1257 3 our -PRON- PRP$ cord-014516-r59usk02 1257 4 main main JJ cord-014516-r59usk02 1257 5 objective objective NN cord-014516-r59usk02 1257 6 was be VBD cord-014516-r59usk02 1257 7 to to TO cord-014516-r59usk02 1257 8 describe describe VB cord-014516-r59usk02 1257 9 SBP SBP NNP cord-014516-r59usk02 1257 10 in in RP cord-014516-r59usk02 1257 11 clinically clinically RB cord-014516-r59usk02 1257 12 ill ill JJ cord-014516-r59usk02 1257 13 FIVpositive fivpositive JJ cord-014516-r59usk02 1257 14 cats cat NNS cord-014516-r59usk02 1257 15 . . . cord-014516-r59usk02 1258 1 Secondly secondly RB cord-014516-r59usk02 1258 2 we -PRON- PRP cord-014516-r59usk02 1258 3 aimed aim VBD cord-014516-r59usk02 1258 4 to to TO cord-014516-r59usk02 1258 5 evaluate evaluate VB cord-014516-r59usk02 1258 6 routine routine JJ cord-014516-r59usk02 1258 7 renal renal JJ cord-014516-r59usk02 1258 8 variables variable NNS cord-014516-r59usk02 1258 9 in in IN cord-014516-r59usk02 1258 10 this this DT cord-014516-r59usk02 1258 11 population population NN cord-014516-r59usk02 1258 12 . . . cord-014516-r59usk02 1259 1 Naturally naturally RB cord-014516-r59usk02 1259 2 infected infect VBN cord-014516-r59usk02 1259 3 clinically clinically RB cord-014516-r59usk02 1259 4 ill ill JJ cord-014516-r59usk02 1259 5 FIV fiv NN cord-014516-r59usk02 1259 6 - - HYPH cord-014516-r59usk02 1259 7 positive positive JJ cord-014516-r59usk02 1259 8 cats cat NNS cord-014516-r59usk02 1259 9 were be VBD cord-014516-r59usk02 1259 10 prospectively prospectively RB cord-014516-r59usk02 1259 11 included include VBN cord-014516-r59usk02 1259 12 . . . cord-014516-r59usk02 1260 1 The the DT cord-014516-r59usk02 1260 2 Doppler Doppler NNP cord-014516-r59usk02 1260 3 ultrasonic ultrasonic JJ cord-014516-r59usk02 1260 4 technique technique NN cord-014516-r59usk02 1260 5 was be VBD cord-014516-r59usk02 1260 6 used use VBN cord-014516-r59usk02 1260 7 to to TO cord-014516-r59usk02 1260 8 measure measure VB cord-014516-r59usk02 1260 9 SBP SBP NNP cord-014516-r59usk02 1260 10 according accord VBG cord-014516-r59usk02 1260 11 to to IN cord-014516-r59usk02 1260 12 ACVIM ACVIM NNP cord-014516-r59usk02 1260 13 guidelines guideline NNS cord-014516-r59usk02 1260 14 . . . cord-014516-r59usk02 1261 1 Serum serum NN cord-014516-r59usk02 1261 2 creatinine creatinine NN cord-014516-r59usk02 1261 3 ( ( -LRB- cord-014516-r59usk02 1261 4 sCreat sCreat NNP cord-014516-r59usk02 1261 5 ) ) -RRB- cord-014516-r59usk02 1261 6 and and CC cord-014516-r59usk02 1261 7 urea urea NN cord-014516-r59usk02 1261 8 ( ( -LRB- cord-014516-r59usk02 1261 9 sUrea sUrea NNP cord-014516-r59usk02 1261 10 ) ) -RRB- cord-014516-r59usk02 1261 11 concentrations concentration NNS cord-014516-r59usk02 1261 12 , , , cord-014516-r59usk02 1261 13 urine urine VB cord-014516-r59usk02 1261 14 specific specific JJ cord-014516-r59usk02 1261 15 gravity gravity NN cord-014516-r59usk02 1261 16 ( ( -LRB- cord-014516-r59usk02 1261 17 USG USG NNP cord-014516-r59usk02 1261 18 ) ) -RRB- cord-014516-r59usk02 1261 19 and and CC cord-014516-r59usk02 1261 20 urinary urinary JJ cord-014516-r59usk02 1261 21 protein protein NN cord-014516-r59usk02 1261 22 : : : cord-014516-r59usk02 1261 23 creatinine creatinine NN cord-014516-r59usk02 1261 24 ratio ratio NN cord-014516-r59usk02 1261 25 ( ( -LRB- cord-014516-r59usk02 1261 26 UPC UPC NNP cord-014516-r59usk02 1261 27 ) ) -RRB- cord-014516-r59usk02 1261 28 were be VBD cord-014516-r59usk02 1261 29 determined determine VBN cord-014516-r59usk02 1261 30 . . . cord-014516-r59usk02 1262 1 The the DT cord-014516-r59usk02 1262 2 study study NN cord-014516-r59usk02 1262 3 included include VBD cord-014516-r59usk02 1262 4 99 99 CD cord-014516-r59usk02 1262 5 cats cat NNS cord-014516-r59usk02 1262 6 , , , cord-014516-r59usk02 1262 7 with with IN cord-014516-r59usk02 1262 8 a a DT cord-014516-r59usk02 1262 9 mean mean JJ cord-014516-r59usk02 1262 10 age age NN cord-014516-r59usk02 1262 11 of of IN cord-014516-r59usk02 1262 12 8.0 8.0 CD cord-014516-r59usk02 1262 13 AE AE NNP cord-014516-r59usk02 1262 14 3.7 3.7 CD cord-014516-r59usk02 1262 15 years year NNS cord-014516-r59usk02 1262 16 and and CC cord-014516-r59usk02 1262 17 a a DT cord-014516-r59usk02 1262 18 mean mean JJ cord-014516-r59usk02 1262 19 body body NN cord-014516-r59usk02 1262 20 condition condition NN cord-014516-r59usk02 1262 21 score score NN cord-014516-r59usk02 1262 22 of of IN cord-014516-r59usk02 1262 23 4.6 4.6 CD cord-014516-r59usk02 1262 24 AE AE NNP cord-014516-r59usk02 1262 25 1.5 1.5 CD cord-014516-r59usk02 1262 26 on on IN cord-014516-r59usk02 1262 27 a a DT cord-014516-r59usk02 1262 28 nine nine CD cord-014516-r59usk02 1262 29 - - HYPH cord-014516-r59usk02 1262 30 point point NN cord-014516-r59usk02 1262 31 scale scale NN cord-014516-r59usk02 1262 32 . . . cord-014516-r59usk02 1263 1 The the DT cord-014516-r59usk02 1263 2 SBP SBP NNP cord-014516-r59usk02 1263 3 ranged range VBD cord-014516-r59usk02 1263 4 from from IN cord-014516-r59usk02 1263 5 91 91 CD cord-014516-r59usk02 1263 6 to to TO cord-014516-r59usk02 1263 7 170 170 CD cord-014516-r59usk02 1263 8 mmHg mmHg NNS cord-014516-r59usk02 1263 9 , , , cord-014516-r59usk02 1263 10 with with IN cord-014516-r59usk02 1263 11 a a DT cord-014516-r59usk02 1263 12 mean mean NN cord-014516-r59usk02 1263 13 of of IN cord-014516-r59usk02 1263 14 116 116 CD cord-014516-r59usk02 1263 15 AE AE NNP cord-014516-r59usk02 1263 16 18 18 CD cord-014516-r59usk02 1263 17 mmHg mmHg NNS cord-014516-r59usk02 1263 18 . . . cord-014516-r59usk02 1264 1 Only only RB cord-014516-r59usk02 1264 2 two two CD cord-014516-r59usk02 1264 3 cats cat NNS cord-014516-r59usk02 1264 4 were be VBD cord-014516-r59usk02 1264 5 hypertensive hypertensive JJ cord-014516-r59usk02 1264 6 ( ( -LRB- cord-014516-r59usk02 1264 7 SBP SBP NNP cord-014516-r59usk02 1264 8 > > XX cord-014516-r59usk02 1264 9 160 160 CD cord-014516-r59usk02 1264 10 mmHg mmHg NNS cord-014516-r59usk02 1264 11 ) ) -RRB- cord-014516-r59usk02 1264 12 . . . cord-014516-r59usk02 1265 1 Both both DT cord-014516-r59usk02 1265 2 had have VBD cord-014516-r59usk02 1265 3 isosthenuric isosthenuric JJ cord-014516-r59usk02 1265 4 urine urine NN cord-014516-r59usk02 1265 5 , , , cord-014516-r59usk02 1265 6 were be VBD cord-014516-r59usk02 1265 7 borderline borderline JJ cord-014516-r59usk02 1265 8 proteinuric proteinuric NN cord-014516-r59usk02 1265 9 ( ( -LRB- cord-014516-r59usk02 1266 1 UPC UPC NNP cord-014516-r59usk02 1266 2 0.2 0.2 CD cord-014516-r59usk02 1266 3 - - HYPH cord-014516-r59usk02 1266 4 0.4 0.4 CD cord-014516-r59usk02 1266 5 ) ) -RRB- cord-014516-r59usk02 1266 6 and and CC cord-014516-r59usk02 1266 7 one one CD cord-014516-r59usk02 1266 8 of of IN cord-014516-r59usk02 1266 9 them -PRON- PRP cord-014516-r59usk02 1266 10 was be VBD cord-014516-r59usk02 1266 11 mildly mildly RB cord-014516-r59usk02 1266 12 azotemic azotemic JJ cord-014516-r59usk02 1266 13 . . . cord-014516-r59usk02 1267 1 Mean mean JJ cord-014516-r59usk02 1267 2 sCreat sCreat NNP cord-014516-r59usk02 1267 3 was be VBD cord-014516-r59usk02 1267 4 101.7 101.7 CD cord-014516-r59usk02 1267 5 AE AE NNP cord-014516-r59usk02 1267 6 64.2 64.2 CD cord-014516-r59usk02 1267 7 lmol lmol JJ cord-014516-r59usk02 1268 1 /L /L . cord-014516-r59usk02 1268 2 ( ( -LRB- cord-014516-r59usk02 1268 3 reference reference NN cord-014516-r59usk02 1268 4 interval interval NN cord-014516-r59usk02 1268 5 ( ( -LRB- cord-014516-r59usk02 1268 6 RI RI NNP cord-014516-r59usk02 1268 7 ) ) -RRB- cord-014516-r59usk02 1268 8 44.2 44.2 CD cord-014516-r59usk02 1268 9 - - HYPH cord-014516-r59usk02 1268 10 141.4 141.4 CD cord-014516-r59usk02 1268 11 lmol lmol NNP cord-014516-r59usk02 1268 12 / / SYM cord-014516-r59usk02 1268 13 L l NN cord-014516-r59usk02 1268 14 ) ) -RRB- cord-014516-r59usk02 1269 1 and and CC cord-014516-r59usk02 1269 2 mean mean VB cord-014516-r59usk02 1269 3 sUrea sUrea NNP cord-014516-r59usk02 1269 4 concentration concentration NN cord-014516-r59usk02 1269 5 8.6 8.6 CD cord-014516-r59usk02 1269 6 AE AE NNP cord-014516-r59usk02 1269 7 5.2 5.2 CD cord-014516-r59usk02 1269 8 mmol mmol JJ cord-014516-r59usk02 1269 9 / / SYM cord-014516-r59usk02 1269 10 L l NN cord-014516-r59usk02 1269 11 ( ( -LRB- cord-014516-r59usk02 1269 12 RI RI NNP cord-014516-r59usk02 1269 13 6.2 6.2 CD cord-014516-r59usk02 1269 14 - - HYPH cord-014516-r59usk02 1269 15 10.8 10.8 CD cord-014516-r59usk02 1269 16 mmol mmol NNP cord-014516-r59usk02 1269 17 / / SYM cord-014516-r59usk02 1269 18 L L NNP cord-014516-r59usk02 1269 19 ) ) -RRB- cord-014516-r59usk02 1269 20 . . . cord-014516-r59usk02 1270 1 Thirteen thirteen CD cord-014516-r59usk02 1270 2 cats cat NNS cord-014516-r59usk02 1270 3 showed show VBD cord-014516-r59usk02 1270 4 increased increase VBN cord-014516-r59usk02 1270 5 sCreat sCreat NNP cord-014516-r59usk02 1270 6 levels level NNS cord-014516-r59usk02 1270 7 , , , cord-014516-r59usk02 1270 8 with with IN cord-014516-r59usk02 1270 9 decreased decrease VBN cord-014516-r59usk02 1270 10 USG USG NNP cord-014516-r59usk02 1270 11 ( ( -LRB- cord-014516-r59usk02 1270 12 < < XX cord-014516-r59usk02 1270 13 1.035 1.035 CD cord-014516-r59usk02 1270 14 ) ) -RRB- cord-014516-r59usk02 1270 15 in in IN cord-014516-r59usk02 1270 16 eight eight CD cord-014516-r59usk02 1270 17 , , , cord-014516-r59usk02 1270 18 proteinuria proteinuria NN cord-014516-r59usk02 1270 19 ( ( -LRB- cord-014516-r59usk02 1270 20 UPC UPC NNP cord-014516-r59usk02 1270 21 > > XX cord-014516-r59usk02 1270 22 0.4 0.4 CD cord-014516-r59usk02 1270 23 ) ) -RRB- cord-014516-r59usk02 1270 24 in in IN cord-014516-r59usk02 1270 25 seven seven CD cord-014516-r59usk02 1270 26 and and CC cord-014516-r59usk02 1270 27 increased increase VBN cord-014516-r59usk02 1270 28 sUrea sUrea NNP cord-014516-r59usk02 1270 29 concentrations concentration NNS cord-014516-r59usk02 1270 30 in in IN cord-014516-r59usk02 1270 31 ten ten CD cord-014516-r59usk02 1270 32 of of IN cord-014516-r59usk02 1270 33 them -PRON- PRP cord-014516-r59usk02 1270 34 . . . cord-014516-r59usk02 1271 1 Five five CD cord-014516-r59usk02 1271 2 out out IN cord-014516-r59usk02 1271 3 of of IN cord-014516-r59usk02 1271 4 ten ten CD cord-014516-r59usk02 1271 5 azotemic azotemic JJ cord-014516-r59usk02 1271 6 cats cat NNS cord-014516-r59usk02 1271 7 were be VBD cord-014516-r59usk02 1271 8 proteinuric proteinuric JJ cord-014516-r59usk02 1271 9 with with IN cord-014516-r59usk02 1271 10 a a DT cord-014516-r59usk02 1271 11 decreased decrease VBN cord-014516-r59usk02 1271 12 USG USG NNP cord-014516-r59usk02 1271 13 . . . cord-014516-r59usk02 1272 1 Mean mean JJ cord-014516-r59usk02 1272 2 UPC UPC NNP cord-014516-r59usk02 1272 3 was be VBD cord-014516-r59usk02 1272 4 0.26 0.26 CD cord-014516-r59usk02 1272 5 AE AE NNP cord-014516-r59usk02 1272 6 1.06 1.06 CD cord-014516-r59usk02 1272 7 , , , cord-014516-r59usk02 1272 8 with with IN cord-014516-r59usk02 1272 9 a a DT cord-014516-r59usk02 1272 10 wide wide JJ cord-014516-r59usk02 1272 11 range range NN cord-014516-r59usk02 1272 12 from from IN cord-014516-r59usk02 1272 13 0.05 0.05 CD cord-014516-r59usk02 1272 14 to to IN cord-014516-r59usk02 1272 15 9.38 9.38 CD cord-014516-r59usk02 1272 16 . . . cord-014516-r59usk02 1273 1 Borderline borderline JJ cord-014516-r59usk02 1273 2 proteinuria proteinuria NN cord-014516-r59usk02 1273 3 was be VBD cord-014516-r59usk02 1273 4 present present JJ cord-014516-r59usk02 1273 5 in in IN cord-014516-r59usk02 1273 6 40/99 40/99 CD cord-014516-r59usk02 1273 7 ( ( -LRB- cord-014516-r59usk02 1273 8 40.4 40.4 CD cord-014516-r59usk02 1273 9 % % NN cord-014516-r59usk02 1273 10 ) ) -RRB- cord-014516-r59usk02 1273 11 and and CC cord-014516-r59usk02 1273 12 proteinuria proteinuria NN cord-014516-r59usk02 1273 13 in in IN cord-014516-r59usk02 1273 14 28/99 28/99 CD cord-014516-r59usk02 1273 15 ( ( -LRB- cord-014516-r59usk02 1273 16 28.3 28.3 CD cord-014516-r59usk02 1273 17 % % NN cord-014516-r59usk02 1273 18 ) ) -RRB- cord-014516-r59usk02 1273 19 . . . cord-014516-r59usk02 1274 1 Half half NN cord-014516-r59usk02 1274 2 of of IN cord-014516-r59usk02 1274 3 the the DT cord-014516-r59usk02 1274 4 proteinuric proteinuric JJ cord-014516-r59usk02 1274 5 cats cat NNS cord-014516-r59usk02 1274 6 had have VBD cord-014516-r59usk02 1274 7 a a DT cord-014516-r59usk02 1274 8 decreased decrease VBN cord-014516-r59usk02 1274 9 USG USG NNP cord-014516-r59usk02 1274 10 . . . cord-014516-r59usk02 1275 1 Mean mean JJ cord-014516-r59usk02 1275 2 USG USG NNP cord-014516-r59usk02 1275 3 was be VBD cord-014516-r59usk02 1275 4 1.040 1.040 CD cord-014516-r59usk02 1275 5 AE AE NNP cord-014516-r59usk02 1275 6 0.013 0.013 CD cord-014516-r59usk02 1275 7 . . . cord-014516-r59usk02 1276 1 One one CD cord-014516-r59usk02 1276 2 third third NN cord-014516-r59usk02 1276 3 of of IN cord-014516-r59usk02 1276 4 all all DT cord-014516-r59usk02 1276 5 cats cat NNS cord-014516-r59usk02 1276 6 had have VBD cord-014516-r59usk02 1276 7 a a DT cord-014516-r59usk02 1276 8 decreased decrease VBN cord-014516-r59usk02 1276 9 USG USG NNP cord-014516-r59usk02 1276 10 , , , cord-014516-r59usk02 1276 11 with with IN cord-014516-r59usk02 1276 12 isosthenuria isosthenuria NNS cord-014516-r59usk02 1276 13 in in IN cord-014516-r59usk02 1276 14 seven seven CD cord-014516-r59usk02 1276 15 of of IN cord-014516-r59usk02 1276 16 them -PRON- PRP cord-014516-r59usk02 1276 17 . . . cord-014516-r59usk02 1277 1 These these DT cord-014516-r59usk02 1277 2 results result NNS cord-014516-r59usk02 1277 3 demonstrate demonstrate VBP cord-014516-r59usk02 1277 4 that that IN cord-014516-r59usk02 1277 5 proteinuria proteinuria NN cord-014516-r59usk02 1277 6 and and CC cord-014516-r59usk02 1277 7 poorly poorly RB cord-014516-r59usk02 1277 8 concentrated concentrated JJ cord-014516-r59usk02 1277 9 urine urine NN cord-014516-r59usk02 1277 10 are be VBP cord-014516-r59usk02 1277 11 common common JJ cord-014516-r59usk02 1277 12 in in IN cord-014516-r59usk02 1277 13 naturally naturally RB cord-014516-r59usk02 1277 14 infected infect VBN cord-014516-r59usk02 1277 15 clinically clinically RB cord-014516-r59usk02 1277 16 ill ill JJ cord-014516-r59usk02 1277 17 FIVpositive fivpositive JJ cord-014516-r59usk02 1277 18 cats cat NNS cord-014516-r59usk02 1277 19 , , , cord-014516-r59usk02 1277 20 confirming confirm VBG cord-014516-r59usk02 1277 21 previous previous JJ cord-014516-r59usk02 1277 22 reports report NNS cord-014516-r59usk02 1277 23 in in IN cord-014516-r59usk02 1277 24 cats cat NNS cord-014516-r59usk02 1277 25 and and CC cord-014516-r59usk02 1277 26 humans human NNS cord-014516-r59usk02 1277 27 . . . cord-014516-r59usk02 1278 1 However however RB cord-014516-r59usk02 1278 2 , , , cord-014516-r59usk02 1278 3 longitudinal longitudinal JJ cord-014516-r59usk02 1278 4 studies study NNS cord-014516-r59usk02 1278 5 of of IN cord-014516-r59usk02 1278 6 ( ( -LRB- cord-014516-r59usk02 1278 7 borderline borderline NNP cord-014516-r59usk02 1278 8 ) ) -RRB- cord-014516-r59usk02 1278 9 proteinuric proteinuric JJ cord-014516-r59usk02 1278 10 patients patient NNS cord-014516-r59usk02 1278 11 are be VBP cord-014516-r59usk02 1278 12 needed need VBN cord-014516-r59usk02 1278 13 to to TO cord-014516-r59usk02 1278 14 elucidate elucidate VB cord-014516-r59usk02 1278 15 the the DT cord-014516-r59usk02 1278 16 clinical clinical JJ cord-014516-r59usk02 1278 17 relevance relevance NN cord-014516-r59usk02 1278 18 . . . cord-014516-r59usk02 1279 1 The the DT cord-014516-r59usk02 1279 2 low low JJ cord-014516-r59usk02 1279 3 number number NN cord-014516-r59usk02 1279 4 of of IN cord-014516-r59usk02 1279 5 hypertensive hypertensive JJ cord-014516-r59usk02 1279 6 patients patient NNS cord-014516-r59usk02 1279 7 and and CC cord-014516-r59usk02 1279 8 low low JJ cord-014516-r59usk02 1279 9 mean mean NN cord-014516-r59usk02 1279 10 SBP SBP NNP cord-014516-r59usk02 1279 11 in in IN cord-014516-r59usk02 1279 12 our -PRON- PRP$ cord-014516-r59usk02 1279 13 study study NN cord-014516-r59usk02 1279 14 indicate indicate VBP cord-014516-r59usk02 1279 15 that that IN cord-014516-r59usk02 1279 16 hypertension hypertension NN cord-014516-r59usk02 1279 17 is be VBZ cord-014516-r59usk02 1279 18 uncommon uncommon JJ cord-014516-r59usk02 1279 19 and and CC cord-014516-r59usk02 1279 20 unlikely unlikely JJ cord-014516-r59usk02 1279 21 to to TO cord-014516-r59usk02 1279 22 be be VB cord-014516-r59usk02 1279 23 the the DT cord-014516-r59usk02 1279 24 cause cause NN cord-014516-r59usk02 1279 25 of of IN cord-014516-r59usk02 1279 26 renal renal JJ cord-014516-r59usk02 1279 27 damage damage NN cord-014516-r59usk02 1279 28 in in IN cord-014516-r59usk02 1279 29 clinically clinically RB cord-014516-r59usk02 1279 30 ill ill JJ cord-014516-r59usk02 1279 31 FIV fiv NN cord-014516-r59usk02 1279 32 - - HYPH cord-014516-r59usk02 1279 33 infected infect VBN cord-014516-r59usk02 1279 34 cats cat NNS cord-014516-r59usk02 1279 35 . . . cord-014516-r59usk02 1280 1 Aratana Aratana NNP cord-014516-r59usk02 1280 2 Therapeutics Therapeutics NNP cord-014516-r59usk02 1280 3 NV NV NNP cord-014516-r59usk02 1280 4 financially financially RB cord-014516-r59usk02 1280 5 supports support VBZ cord-014516-r59usk02 1280 6 a a DT cord-014516-r59usk02 1280 7 clinical clinical JJ cord-014516-r59usk02 1280 8 trial trial NN cord-014516-r59usk02 1280 9 on on IN cord-014516-r59usk02 1280 10 the the DT cord-014516-r59usk02 1280 11 use use NN cord-014516-r59usk02 1280 12 of of IN cord-014516-r59usk02 1280 13 antivirals antiviral NNS cord-014516-r59usk02 1280 14 in in IN cord-014516-r59usk02 1280 15 FIV FIV NNP cord-014516-r59usk02 1280 16 cats cat NNS cord-014516-r59usk02 1280 17 at at IN cord-014516-r59usk02 1280 18 our -PRON- PRP$ cord-014516-r59usk02 1280 19 university university NN cord-014516-r59usk02 1280 20 . . . cord-014516-r59usk02 1281 1 Screeninng Screeninng NNP cord-014516-r59usk02 1281 2 examinations examination NNS cord-014516-r59usk02 1281 3 repoorted repoorte VBN cord-014516-r59usk02 1281 4 in in IN cord-014516-r59usk02 1281 5 this this DT cord-014516-r59usk02 1281 6 trial trial NN cord-014516-r59usk02 1281 7 were be VBD cord-014516-r59usk02 1281 8 part part NN cord-014516-r59usk02 1281 9 of of IN cord-014516-r59usk02 1281 10 the the DT cord-014516-r59usk02 1281 11 required require VBN cord-014516-r59usk02 1281 12 pre pre JJ cord-014516-r59usk02 1281 13 - - JJ cord-014516-r59usk02 1281 14 trial trial JJ cord-014516-r59usk02 1281 15 investigations investigation NNS cord-014516-r59usk02 1281 16 for for IN cord-014516-r59usk02 1281 17 that that DT cord-014516-r59usk02 1281 18 study study NN cord-014516-r59usk02 1281 19 . . . cord-014516-r59usk02 1282 1 The the DT cord-014516-r59usk02 1282 2 presenting present VBG cord-014516-r59usk02 1282 3 author author NN cord-014516-r59usk02 1282 4 is be VBZ cord-014516-r59usk02 1282 5 also also RB cord-014516-r59usk02 1282 6 funded fund VBN cord-014516-r59usk02 1282 7 by by IN cord-014516-r59usk02 1282 8 a a DT cord-014516-r59usk02 1282 9 scholarship scholarship NN cord-014516-r59usk02 1282 10 from from IN cord-014516-r59usk02 1282 11 Aratana Aratana NNP cord-014516-r59usk02 1282 12 Therapeutics Therapeutics NNP cord-014516-r59usk02 1282 13 AV AV NNP cord-014516-r59usk02 1282 14 . . . cord-014516-r59usk02 1283 1 The the DT cord-014516-r59usk02 1283 2 objective objective NN cord-014516-r59usk02 1283 3 of of IN cord-014516-r59usk02 1283 4 this this DT cord-014516-r59usk02 1283 5 study study NN cord-014516-r59usk02 1283 6 was be VBD cord-014516-r59usk02 1283 7 to to TO cord-014516-r59usk02 1283 8 identify identify VB cord-014516-r59usk02 1283 9 the the DT cord-014516-r59usk02 1283 10 prevalence prevalence NN cord-014516-r59usk02 1283 11 of of IN cord-014516-r59usk02 1283 12 bacterial bacterial JJ cord-014516-r59usk02 1283 13 species specie NNS cord-014516-r59usk02 1283 14 and and CC cord-014516-r59usk02 1283 15 the the DT cord-014516-r59usk02 1283 16 susceptibility susceptibility NN cord-014516-r59usk02 1283 17 of of IN cord-014516-r59usk02 1283 18 isolates isolate NNS cord-014516-r59usk02 1283 19 to to IN cord-014516-r59usk02 1283 20 doxycycline doxycycline NN cord-014516-r59usk02 1283 21 , , , cord-014516-r59usk02 1283 22 trimethoprim trimethoprim NNP cord-014516-r59usk02 1283 23 - - HYPH cord-014516-r59usk02 1283 24 sulfamethoxazole sulfamethoxazole NNP cord-014516-r59usk02 1283 25 ( ( -LRB- cord-014516-r59usk02 1283 26 TMS TMS NNP cord-014516-r59usk02 1283 27 ) ) -RRB- cord-014516-r59usk02 1283 28 , , , cord-014516-r59usk02 1283 29 ampicillin ampicillin NN cord-014516-r59usk02 1283 30 , , , cord-014516-r59usk02 1283 31 amoxicillinclavulanic amoxicillinclavulanic JJ cord-014516-r59usk02 1283 32 acid acid NN cord-014516-r59usk02 1283 33 ( ( -LRB- cord-014516-r59usk02 1283 34 AMC AMC NNP cord-014516-r59usk02 1283 35 ) ) -RRB- cord-014516-r59usk02 1283 36 , , , cord-014516-r59usk02 1283 37 cephalothin cephalothin NNP cord-014516-r59usk02 1283 38 , , , cord-014516-r59usk02 1283 39 and and CC cord-014516-r59usk02 1283 40 enrofloxacin enrofloxacin NNS cord-014516-r59usk02 1283 41 in in IN cord-014516-r59usk02 1283 42 cats cat NNS cord-014516-r59usk02 1283 43 with with IN cord-014516-r59usk02 1283 44 urinary urinary JJ cord-014516-r59usk02 1283 45 tract tract NN cord-014516-r59usk02 1283 46 infections infection NNS cord-014516-r59usk02 1283 47 ( ( -LRB- cord-014516-r59usk02 1283 48 UTI UTI NNP cord-014516-r59usk02 1283 49 ) ) -RRB- cord-014516-r59usk02 1283 50 with with IN cord-014516-r59usk02 1283 51 and and CC cord-014516-r59usk02 1283 52 without without IN cord-014516-r59usk02 1283 53 predisposing predispose VBG cord-014516-r59usk02 1283 54 comorbidities comorbiditie NNS cord-014516-r59usk02 1283 55 . . . cord-014516-r59usk02 1284 1 A a DT cord-014516-r59usk02 1284 2 retrospective retrospective JJ cord-014516-r59usk02 1284 3 analysis analysis NN cord-014516-r59usk02 1284 4 of of IN cord-014516-r59usk02 1284 5 case case NN cord-014516-r59usk02 1284 6 records record NNS cord-014516-r59usk02 1284 7 between between IN cord-014516-r59usk02 1284 8 2000 2000 CD cord-014516-r59usk02 1284 9 and and CC cord-014516-r59usk02 1284 10 2009 2009 CD cord-014516-r59usk02 1284 11 was be VBD cord-014516-r59usk02 1284 12 performed perform VBN cord-014516-r59usk02 1284 13 and and CC cord-014516-r59usk02 1284 14 resulted result VBD cord-014516-r59usk02 1284 15 in in IN cord-014516-r59usk02 1284 16 inclusion inclusion NN cord-014516-r59usk02 1284 17 271 271 CD cord-014516-r59usk02 1284 18 cats cat NNS cord-014516-r59usk02 1284 19 into into IN cord-014516-r59usk02 1284 20 the the DT cord-014516-r59usk02 1284 21 study study NN cord-014516-r59usk02 1284 22 : : : cord-014516-r59usk02 1284 23 128 128 CD cord-014516-r59usk02 1284 24 cats cat NNS cord-014516-r59usk02 1284 25 with with IN cord-014516-r59usk02 1284 26 a a DT cord-014516-r59usk02 1284 27 systemic systemic JJ cord-014516-r59usk02 1284 28 comorbidity comorbidity NN cord-014516-r59usk02 1284 29 , , , cord-014516-r59usk02 1284 30 36 36 CD cord-014516-r59usk02 1284 31 cats cat NNS cord-014516-r59usk02 1284 32 with with IN cord-014516-r59usk02 1284 33 indwelling indwell VBG cord-014516-r59usk02 1284 34 urinary urinary JJ cord-014516-r59usk02 1284 35 catheters catheter NNS cord-014516-r59usk02 1284 36 , , , cord-014516-r59usk02 1284 37 40 40 CD cord-014516-r59usk02 1284 38 cats cat NNS cord-014516-r59usk02 1284 39 with with IN cord-014516-r59usk02 1284 40 other other JJ cord-014516-r59usk02 1284 41 local local JJ cord-014516-r59usk02 1284 42 comorbidities comorbiditie NNS cord-014516-r59usk02 1284 43 , , , cord-014516-r59usk02 1284 44 and and CC cord-014516-r59usk02 1284 45 67 67 CD cord-014516-r59usk02 1284 46 cats cat NNS cord-014516-r59usk02 1284 47 with with IN cord-014516-r59usk02 1284 48 no no DT cord-014516-r59usk02 1284 49 comorbidity comorbidity NN cord-014516-r59usk02 1284 50 . . . cord-014516-r59usk02 1285 1 The the DT cord-014516-r59usk02 1285 2 most most RBS cord-014516-r59usk02 1285 3 commonly commonly RB cord-014516-r59usk02 1285 4 isolated isolate VBN cord-014516-r59usk02 1285 5 bacteria bacteria NNS cord-014516-r59usk02 1285 6 were be VBD cord-014516-r59usk02 1285 7 Escherichia Escherichia NNP cord-014516-r59usk02 1285 8 coli coli NNS cord-014516-r59usk02 1285 9 ( ( -LRB- cord-014516-r59usk02 1285 10 E. E. NNP cord-014516-r59usk02 1285 11 coli coli NNS cord-014516-r59usk02 1285 12 ) ) -RRB- cord-014516-r59usk02 1285 13 , , , cord-014516-r59usk02 1285 14 Streptococcus streptococcus NN cord-014516-r59usk02 1285 15 species specie NNS cord-014516-r59usk02 1285 16 ( ( -LRB- cord-014516-r59usk02 1285 17 spp spp NNS cord-014516-r59usk02 1285 18 . . . cord-014516-r59usk02 1285 19 ) ) -RRB- cord-014516-r59usk02 1285 20 , , , cord-014516-r59usk02 1285 21 Staphylococcus Staphylococcus NNP cord-014516-r59usk02 1285 22 spp spp NNS cord-014516-r59usk02 1285 23 . . . cord-014516-r59usk02 1286 1 , , , cord-014516-r59usk02 1287 1 and and CC cord-014516-r59usk02 1287 2 Enterococcus Enterococcus NNP cord-014516-r59usk02 1287 3 spp spp NNP cord-014516-r59usk02 1287 4 .. .. . cord-014516-r59usk02 1288 1 The the DT cord-014516-r59usk02 1288 2 proportion proportion NN cord-014516-r59usk02 1288 3 of of IN cord-014516-r59usk02 1288 4 Gram gram NN cord-014516-r59usk02 1288 5 - - HYPH cord-014516-r59usk02 1288 6 negative negative JJ cord-014516-r59usk02 1288 7 isolates isolate NNS cord-014516-r59usk02 1288 8 was be VBD cord-014516-r59usk02 1288 9 significantly significantly RB cord-014516-r59usk02 1288 10 higher high JJR cord-014516-r59usk02 1288 11 in in IN cord-014516-r59usk02 1288 12 the the DT cord-014516-r59usk02 1288 13 cats cat NNS cord-014516-r59usk02 1288 14 with with IN cord-014516-r59usk02 1288 15 systemic systemic JJ cord-014516-r59usk02 1288 16 comorbidities comorbiditie NNS cord-014516-r59usk02 1288 17 than than IN cord-014516-r59usk02 1288 18 in in IN cord-014516-r59usk02 1288 19 cats cat NNS cord-014516-r59usk02 1288 20 with with IN cord-014516-r59usk02 1288 21 indwelling indwell VBG cord-014516-r59usk02 1288 22 urinary urinary JJ cord-014516-r59usk02 1288 23 catheters catheter NNS cord-014516-r59usk02 1288 24 ( ( -LRB- cord-014516-r59usk02 1288 25 p p NN cord-014516-r59usk02 1288 26 < < XX cord-014516-r59usk02 1288 27 0.001 0.001 CD cord-014516-r59usk02 1288 28 ) ) -RRB- cord-014516-r59usk02 1288 29 and and CC cord-014516-r59usk02 1288 30 cats cat NNS cord-014516-r59usk02 1288 31 with with IN cord-014516-r59usk02 1288 32 other other JJ cord-014516-r59usk02 1288 33 local local JJ cord-014516-r59usk02 1288 34 abnormalities abnormality NNS cord-014516-r59usk02 1288 35 ( ( -LRB- cord-014516-r59usk02 1288 36 P p NN cord-014516-r59usk02 1288 37 < < XX cord-014516-r59usk02 1288 38 0.001 0.001 CD cord-014516-r59usk02 1288 39 ) ) -RRB- cord-014516-r59usk02 1288 40 , , , cord-014516-r59usk02 1288 41 whereas whereas IN cord-014516-r59usk02 1288 42 Gram gram NN cord-014516-r59usk02 1288 43 - - HYPH cord-014516-r59usk02 1288 44 positive positive JJ cord-014516-r59usk02 1288 45 isolates isolate NNS cord-014516-r59usk02 1288 46 were be VBD cord-014516-r59usk02 1288 47 significantly significantly RB cord-014516-r59usk02 1288 48 more more RBR cord-014516-r59usk02 1288 49 commonly commonly RB cord-014516-r59usk02 1288 50 isolated isolate VBN cord-014516-r59usk02 1288 51 from from IN cord-014516-r59usk02 1288 52 cats cat NNS cord-014516-r59usk02 1288 53 with with IN cord-014516-r59usk02 1288 54 indwelling indwell VBG cord-014516-r59usk02 1288 55 urinary urinary JJ cord-014516-r59usk02 1288 56 catheters catheter NNS cord-014516-r59usk02 1288 57 and and CC cord-014516-r59usk02 1288 58 other other JJ cord-014516-r59usk02 1288 59 local local JJ cord-014516-r59usk02 1288 60 comorbidities comorbiditie NNS cord-014516-r59usk02 1288 61 than than IN cord-014516-r59usk02 1288 62 in in IN cord-014516-r59usk02 1288 63 cats cat NNS cord-014516-r59usk02 1288 64 with with IN cord-014516-r59usk02 1288 65 systemic systemic JJ cord-014516-r59usk02 1288 66 comorbidities comorbiditie NNS cord-014516-r59usk02 1288 67 ( ( -LRB- cord-014516-r59usk02 1288 68 p p NN cord-014516-r59usk02 1288 69 < < XX cord-014516-r59usk02 1288 70 0.001 0.001 CD cord-014516-r59usk02 1288 71 ) ) -RRB- cord-014516-r59usk02 1288 72 . . . cord-014516-r59usk02 1289 1 The the DT cord-014516-r59usk02 1289 2 proportions proportion NNS cord-014516-r59usk02 1289 3 of of IN cord-014516-r59usk02 1289 4 isolates isolate NNS cord-014516-r59usk02 1289 5 susceptible susceptible JJ cord-014516-r59usk02 1289 6 to to IN cord-014516-r59usk02 1289 7 AMC AMC NNP cord-014516-r59usk02 1289 8 , , , cord-014516-r59usk02 1289 9 enrofloxacin enrofloxacin NNS cord-014516-r59usk02 1289 10 , , , cord-014516-r59usk02 1289 11 and and CC cord-014516-r59usk02 1289 12 TMS TMS NNP cord-014516-r59usk02 1289 13 and and CC cord-014516-r59usk02 1289 14 the the DT cord-014516-r59usk02 1289 15 antimicrobial antimicrobial JJ cord-014516-r59usk02 1289 16 impact impact NN cord-014516-r59usk02 1289 17 factors factor NNS cord-014516-r59usk02 1289 18 ( ( -LRB- cord-014516-r59usk02 1289 19 IF if IN cord-014516-r59usk02 1289 20 ) ) -RRB- cord-014516-r59usk02 1289 21 were be VBD cord-014516-r59usk02 1289 22 higher high JJR cord-014516-r59usk02 1289 23 than than IN cord-014516-r59usk02 1289 24 the the DT cord-014516-r59usk02 1289 25 proportions proportion NNS cord-014516-r59usk02 1289 26 of of IN cord-014516-r59usk02 1289 27 isolates isolate NNS cord-014516-r59usk02 1289 28 susceptible susceptible JJ cord-014516-r59usk02 1289 29 to to IN cord-014516-r59usk02 1289 30 doxycycline doxycycline NN cord-014516-r59usk02 1289 31 , , , cord-014516-r59usk02 1289 32 ampicillin ampicillin NN cord-014516-r59usk02 1289 33 , , , cord-014516-r59usk02 1289 34 and and CC cord-014516-r59usk02 1289 35 cephalothin cephalothin NNP cord-014516-r59usk02 1289 36 and and CC cord-014516-r59usk02 1289 37 the the DT cord-014516-r59usk02 1289 38 respective respective JJ cord-014516-r59usk02 1289 39 IF if NN cord-014516-r59usk02 1289 40 . . . cord-014516-r59usk02 1290 1 Based base VBN cord-014516-r59usk02 1290 2 on on IN cord-014516-r59usk02 1290 3 these these DT cord-014516-r59usk02 1290 4 findings finding NNS cord-014516-r59usk02 1290 5 , , , cord-014516-r59usk02 1290 6 AMC AMC NNP cord-014516-r59usk02 1290 7 and and CC cord-014516-r59usk02 1290 8 TMS TMS NNP cord-014516-r59usk02 1290 9 would would MD cord-014516-r59usk02 1290 10 be be VB cord-014516-r59usk02 1290 11 the the DT cord-014516-r59usk02 1290 12 firstchoice firstchoice NN cord-014516-r59usk02 1290 13 antimicrobial antimicrobial JJ cord-014516-r59usk02 1290 14 agents agent NNS cord-014516-r59usk02 1290 15 for for IN cord-014516-r59usk02 1290 16 empiric empiric JJ cord-014516-r59usk02 1290 17 treatment treatment NN cord-014516-r59usk02 1290 18 of of IN cord-014516-r59usk02 1290 19 bacterial bacterial JJ cord-014516-r59usk02 1291 1 The the DT cord-014516-r59usk02 1291 2 increasing increase VBG cord-014516-r59usk02 1291 3 rates rate NNS cord-014516-r59usk02 1291 4 of of IN cord-014516-r59usk02 1291 5 resistance resistance NN cord-014516-r59usk02 1291 6 exhibited exhibit VBN cord-014516-r59usk02 1291 7 by by IN cord-014516-r59usk02 1291 8 uropathogens uropathogen NNS cord-014516-r59usk02 1291 9 represent represent VBP cord-014516-r59usk02 1291 10 a a DT cord-014516-r59usk02 1291 11 serious serious JJ cord-014516-r59usk02 1291 12 problem problem NN cord-014516-r59usk02 1291 13 for for IN cord-014516-r59usk02 1291 14 the the DT cord-014516-r59usk02 1291 15 selection selection NN cord-014516-r59usk02 1291 16 of of IN cord-014516-r59usk02 1291 17 an an DT cord-014516-r59usk02 1291 18 appropriate appropriate JJ cord-014516-r59usk02 1291 19 antibiotic antibiotic NN cord-014516-r59usk02 1291 20 . . . cord-014516-r59usk02 1292 1 The the DT cord-014516-r59usk02 1292 2 aim aim NN cord-014516-r59usk02 1292 3 of of IN cord-014516-r59usk02 1292 4 this this DT cord-014516-r59usk02 1292 5 study study NN cord-014516-r59usk02 1292 6 was be VBD cord-014516-r59usk02 1292 7 to to TO cord-014516-r59usk02 1292 8 determine determine VB cord-014516-r59usk02 1292 9 secular secular JJ cord-014516-r59usk02 1292 10 trends trend NNS cord-014516-r59usk02 1292 11 of of IN cord-014516-r59usk02 1292 12 companion companion NN cord-014516-r59usk02 1292 13 animal animal NN cord-014516-r59usk02 1292 14 urinary urinary JJ cord-014516-r59usk02 1292 15 tract tract NN cord-014516-r59usk02 1292 16 infection infection NN cord-014516-r59usk02 1292 17 ( ( -LRB- cord-014516-r59usk02 1292 18 UTI UTI NNP cord-014516-r59usk02 1292 19 ) ) -RRB- cord-014516-r59usk02 1292 20 that that WDT cord-014516-r59usk02 1292 21 involve involve VBP cord-014516-r59usk02 1292 22 extended extend VBN cord-014516-r59usk02 1292 23 - - HYPH cord-014516-r59usk02 1292 24 spectrum spectrum NN cord-014516-r59usk02 1292 25 b b NN cord-014516-r59usk02 1292 26 - - : cord-014516-r59usk02 1292 27 lactamase lactamase NN cord-014516-r59usk02 1293 1 ( ( -LRB- cord-014516-r59usk02 1293 2 ESBL)-and ESBL)-and NNP cord-014516-r59usk02 1293 3 carbapemenase carbapemenase NN cord-014516-r59usk02 1293 4 - - HYPH cord-014516-r59usk02 1293 5 producing produce VBG cord-014516-r59usk02 1293 6 Gram Gram NNP cord-014516-r59usk02 1293 7 negative negative JJ cord-014516-r59usk02 1293 8 bacteria bacteria NNS cord-014516-r59usk02 1293 9 ( ( -LRB- cord-014516-r59usk02 1293 10 namely namely RB cord-014516-r59usk02 1293 11 , , , cord-014516-r59usk02 1293 12 Escherichia Escherichia NNP cord-014516-r59usk02 1293 13 coli coli NNS cord-014516-r59usk02 1293 14 , , , cord-014516-r59usk02 1293 15 Klebsiella Klebsiella NNP cord-014516-r59usk02 1293 16 pneumoniae pneumoniae NN cord-014516-r59usk02 1293 17 , , , cord-014516-r59usk02 1293 18 Proteus Proteus NNP cord-014516-r59usk02 1293 19 mirabilis mirabilis NNP cord-014516-r59usk02 1293 20 , , , cord-014516-r59usk02 1293 21 Acinetobacter Acinetobacter NNP cord-014516-r59usk02 1293 22 baumannii baumannii NNP cord-014516-r59usk02 1293 23 ) ) -RRB- cord-014516-r59usk02 1293 24 , , . cord-014516-r59usk02 1294 1 methicillin methicillin NN cord-014516-r59usk02 1294 2 - - HYPH cord-014516-r59usk02 1294 3 resistant resistant JJ cord-014516-r59usk02 1294 4 - - HYPH cord-014516-r59usk02 1294 5 staphylococci staphylococcus NNS cord-014516-r59usk02 1294 6 ( ( -LRB- cord-014516-r59usk02 1294 7 MRS MRS NNP cord-014516-r59usk02 1294 8 ) ) -RRB- cord-014516-r59usk02 1294 9 and and CC cord-014516-r59usk02 1294 10 ampicillin ampicillin NN cord-014516-r59usk02 1294 11 and and CC cord-014516-r59usk02 1294 12 high high JJ cord-014516-r59usk02 1294 13 - - HYPH cord-014516-r59usk02 1294 14 level level NN cord-014516-r59usk02 1294 15 - - HYPH cord-014516-r59usk02 1294 16 gentamicin gentamicin NN cord-014516-r59usk02 1294 17 - - HYPH cord-014516-r59usk02 1294 18 resistance resistance NN cord-014516-r59usk02 1294 19 ( ( -LRB- cord-014516-r59usk02 1294 20 HLGR HLGR NNP cord-014516-r59usk02 1294 21 ) ) -RRB- cord-014516-r59usk02 1294 22 enterococci enterococci NNS cord-014516-r59usk02 1294 23 . . . cord-014516-r59usk02 1295 1 Nine nine CD cord-014516-r59usk02 1295 2 hundred hundred CD cord-014516-r59usk02 1295 3 and and CC cord-014516-r59usk02 1295 4 twenty twenty CD cord-014516-r59usk02 1295 5 two two CD cord-014516-r59usk02 1295 6 uropathogenic uropathogenic JJ cord-014516-r59usk02 1295 7 bacteria bacteria NNS cord-014516-r59usk02 1295 8 were be VBD cord-014516-r59usk02 1295 9 isolated isolate VBN cord-014516-r59usk02 1295 10 from from IN cord-014516-r59usk02 1295 11 dogs dog NNS cord-014516-r59usk02 1295 12 and and CC cord-014516-r59usk02 1295 13 cats cat NNS cord-014516-r59usk02 1295 14 , , , cord-014516-r59usk02 1295 15 between between IN cord-014516-r59usk02 1295 16 January January NNP cord-014516-r59usk02 1295 17 1999 1999 CD cord-014516-r59usk02 1295 18 and and CC cord-014516-r59usk02 1295 19 March March NNP cord-014516-r59usk02 1295 20 2014 2014 CD cord-014516-r59usk02 1295 21 , , , cord-014516-r59usk02 1295 22 at at IN cord-014516-r59usk02 1295 23 the the DT cord-014516-r59usk02 1295 24 Veterinary Veterinary NNP cord-014516-r59usk02 1295 25 Teaching Teaching NNP cord-014516-r59usk02 1295 26 Hospital Hospital NNP cord-014516-r59usk02 1295 27 of of IN cord-014516-r59usk02 1295 28 the the DT cord-014516-r59usk02 1295 29 Faculty Faculty NNP cord-014516-r59usk02 1295 30 of of IN cord-014516-r59usk02 1295 31 Veterinary Veterinary NNP cord-014516-r59usk02 1295 32 Medicine Medicine NNP cord-014516-r59usk02 1295 33 and and CC cord-014516-r59usk02 1295 34 at at IN cord-014516-r59usk02 1295 35 veterinary veterinary JJ cord-014516-r59usk02 1295 36 private private JJ cord-014516-r59usk02 1295 37 practices practice NNS cord-014516-r59usk02 1295 38 in in IN cord-014516-r59usk02 1295 39 the the DT cord-014516-r59usk02 1295 40 Lisbon Lisbon NNP cord-014516-r59usk02 1295 41 area area NN cord-014516-r59usk02 1295 42 . . . cord-014516-r59usk02 1296 1 Isolates isolate NNS cord-014516-r59usk02 1296 2 were be VBD cord-014516-r59usk02 1296 3 identified identify VBN cord-014516-r59usk02 1296 4 using use VBG cord-014516-r59usk02 1296 5 standard standard JJ cord-014516-r59usk02 1296 6 commercial commercial JJ cord-014516-r59usk02 1296 7 systems system NNS cord-014516-r59usk02 1296 8 . . . cord-014516-r59usk02 1297 1 Susceptibility susceptibility NN cord-014516-r59usk02 1297 2 testing testing NN cord-014516-r59usk02 1297 3 was be VBD cord-014516-r59usk02 1297 4 performed perform VBN cord-014516-r59usk02 1297 5 using use VBG cord-014516-r59usk02 1297 6 the the DT cord-014516-r59usk02 1297 7 disk disk NN cord-014516-r59usk02 1297 8 diffusion diffusion NN cord-014516-r59usk02 1297 9 and and CC cord-014516-r59usk02 1297 10 broth broth NN cord-014516-r59usk02 1297 11 microdilution microdilution NN cord-014516-r59usk02 1297 12 methods method NNS cord-014516-r59usk02 1297 13 . . . cord-014516-r59usk02 1298 1 CLSI CLSI NNP cord-014516-r59usk02 1298 2 breakpoints breakpoint NNS cord-014516-r59usk02 1298 3 were be VBD cord-014516-r59usk02 1298 4 applied apply VBN cord-014516-r59usk02 1298 5 . . . cord-014516-r59usk02 1299 1 Extended extended JJ cord-014516-r59usk02 1299 2 - - HYPH cord-014516-r59usk02 1299 3 spectrum spectrum NN cord-014516-r59usk02 1299 4 b b NN cord-014516-r59usk02 1299 5 - - HYPH cord-014516-r59usk02 1299 6 lactamases lactamase NNS cord-014516-r59usk02 1300 1 ( ( -LRB- cord-014516-r59usk02 1300 2 ESBL ESBL NNP cord-014516-r59usk02 1300 3 ) ) -RRB- cord-014516-r59usk02 1300 4 production production NN cord-014516-r59usk02 1300 5 was be VBD cord-014516-r59usk02 1300 6 screened screen VBN cord-014516-r59usk02 1300 7 by by IN cord-014516-r59usk02 1300 8 double double JJ cord-014516-r59usk02 1300 9 - - HYPH cord-014516-r59usk02 1300 10 disk disk NN cord-014516-r59usk02 1300 11 synergy synergy NN cord-014516-r59usk02 1300 12 test test NN cord-014516-r59usk02 1300 13 . . . cord-014516-r59usk02 1301 1 The the DT cord-014516-r59usk02 1301 2 ESBL ESBL NNP cord-014516-r59usk02 1301 3 , , , cord-014516-r59usk02 1301 4 plasmid plasmid NN cord-014516-r59usk02 1301 5 - - HYPH cord-014516-r59usk02 1301 6 mediated mediate VBN cord-014516-r59usk02 1301 7 AmpC AmpC NNP cord-014516-r59usk02 1301 8 , , , cord-014516-r59usk02 1301 9 carbapemenases carbapemenase NNS cord-014516-r59usk02 1301 10 , , , cord-014516-r59usk02 1301 11 mecA mecA NNP cord-014516-r59usk02 1301 12 and and CC cord-014516-r59usk02 1301 13 aac(6')-Ieaph(2'')-Ia aac(6')-Ieaph(2'')-Ia NFP cord-014516-r59usk02 1301 14 genes gene NNS cord-014516-r59usk02 1301 15 were be VBD cord-014516-r59usk02 1301 16 detected detect VBN cord-014516-r59usk02 1301 17 by by IN cord-014516-r59usk02 1301 18 PCR PCR NNP cord-014516-r59usk02 1301 19 and and CC cord-014516-r59usk02 1301 20 gene gene NN cord-014516-r59usk02 1301 21 enzymes enzyme NNS cord-014516-r59usk02 1301 22 were be VBD cord-014516-r59usk02 1301 23 sequenced sequence VBN cord-014516-r59usk02 1301 24 . . . cord-014516-r59usk02 1302 1 Among among IN cord-014516-r59usk02 1302 2 Enterobacteriaceae Enterobacteriaceae NNP cord-014516-r59usk02 1302 3 0.7 0.7 CD cord-014516-r59usk02 1302 4 % % NN cord-014516-r59usk02 1302 5 were be VBD cord-014516-r59usk02 1302 6 DHAproducers dhaproducer NNS cord-014516-r59usk02 1302 7 , , , cord-014516-r59usk02 1302 8 2.7 2.7 CD cord-014516-r59usk02 1302 9 % % NN cord-014516-r59usk02 1302 10 were be VBD cord-014516-r59usk02 1302 11 ESBL ESBL NNP cord-014516-r59usk02 1302 12 - - HYPH cord-014516-r59usk02 1302 13 producers producer NNS cord-014516-r59usk02 1302 14 and and CC cord-014516-r59usk02 1302 15 3.6 3.6 CD cord-014516-r59usk02 1302 16 % % NN cord-014516-r59usk02 1302 17 were be VBD cord-014516-r59usk02 1302 18 CMYproducers cmyproducer NNS cord-014516-r59usk02 1302 19 . . . cord-014516-r59usk02 1303 1 All all DT cord-014516-r59usk02 1303 2 isolates isolate NNS cord-014516-r59usk02 1303 3 were be VBD cord-014516-r59usk02 1303 4 also also RB cord-014516-r59usk02 1303 5 multidrug multidrug NN cord-014516-r59usk02 1303 6 - - HYPH cord-014516-r59usk02 1303 7 resistant resistant JJ cord-014516-r59usk02 1303 8 . . . cord-014516-r59usk02 1304 1 Cefalosporinases Cefalosporinases NNP cord-014516-r59usk02 1304 2 - - HYPH cord-014516-r59usk02 1304 3 producer producer NN cord-014516-r59usk02 1304 4 Enterobacteriaceae Enterobacteriaceae NNP cord-014516-r59usk02 1304 5 were be VBD cord-014516-r59usk02 1304 6 detected detect VBN cord-014516-r59usk02 1304 7 in in IN cord-014516-r59usk02 1304 8 2000 2000 CD cord-014516-r59usk02 1304 9 , , , cord-014516-r59usk02 1304 10 the the DT cord-014516-r59usk02 1304 11 first first JJ cord-014516-r59usk02 1304 12 being be VBG cord-014516-r59usk02 1304 13 a a DT cord-014516-r59usk02 1304 14 CMY-2-producer cmy-2-producer JJ cord-014516-r59usk02 1304 15 E. E. NNP cord-014516-r59usk02 1304 16 coli coli NNS cord-014516-r59usk02 1304 17 . . . cord-014516-r59usk02 1305 1 All all PDT cord-014516-r59usk02 1305 2 the the DT cord-014516-r59usk02 1305 3 ESBL ESBL NNP cord-014516-r59usk02 1305 4 - - HYPH cord-014516-r59usk02 1305 5 producers producer NNS cord-014516-r59usk02 1305 6 were be VBD cord-014516-r59usk02 1305 7 E. E. NNP cord-014516-r59usk02 1305 8 coli coli NNS cord-014516-r59usk02 1305 9 or or CC cord-014516-r59usk02 1305 10 K. K. NNP cord-014516-r59usk02 1305 11 pneumoniae pneumoniae NN cord-014516-r59usk02 1305 12 producing produce VBG cord-014516-r59usk02 1305 13 CTX CTX NNP cord-014516-r59usk02 1305 14 - - HYPH cord-014516-r59usk02 1305 15 M M NNP cord-014516-r59usk02 1305 16 - - HYPH cord-014516-r59usk02 1305 17 group group NN cord-014516-r59usk02 1305 18 1 1 CD cord-014516-r59usk02 1305 19 enzymes enzyme NNS cord-014516-r59usk02 1305 20 . . . cord-014516-r59usk02 1306 1 Ampicillin ampicillin JJ cord-014516-r59usk02 1306 2 - - HYPH cord-014516-r59usk02 1306 3 resistance resistance NN cord-014516-r59usk02 1306 4 in in IN cord-014516-r59usk02 1306 5 enterococci enterococci NNP cord-014516-r59usk02 1306 6 was be VBD cord-014516-r59usk02 1306 7 present present JJ cord-014516-r59usk02 1306 8 throughout throughout IN cord-014516-r59usk02 1306 9 the the DT cord-014516-r59usk02 1306 10 years year NNS cord-014516-r59usk02 1306 11 ( ( -LRB- cord-014516-r59usk02 1306 12 15,4 15,4 CD cord-014516-r59usk02 1306 13 % % NN cord-014516-r59usk02 1306 14 , , , cord-014516-r59usk02 1306 15 n n NN cord-014516-r59usk02 1306 16 = = SYM cord-014516-r59usk02 1306 17 8) 8) NN cord-014516-r59usk02 1306 18 . . . cord-014516-r59usk02 1307 1 HLGR HLGR NNP cord-014516-r59usk02 1307 2 appeared appear VBD cord-014516-r59usk02 1307 3 in in IN cord-014516-r59usk02 1307 4 enterococci enterococci NNS cord-014516-r59usk02 1307 5 in in IN cord-014516-r59usk02 1307 6 2003 2003 CD cord-014516-r59usk02 1307 7 and and CC cord-014516-r59usk02 1307 8 was be VBD cord-014516-r59usk02 1307 9 confirmed confirm VBN cord-014516-r59usk02 1307 10 by by IN cord-014516-r59usk02 1307 11 the the DT cord-014516-r59usk02 1307 12 detection detection NN cord-014516-r59usk02 1307 13 of of IN cord-014516-r59usk02 1307 14 the the DT cord-014516-r59usk02 1307 15 bifunctional bifunctional JJ cord-014516-r59usk02 1307 16 enzyme enzyme NN cord-014516-r59usk02 1307 17 that that WDT cord-014516-r59usk02 1307 18 confers confer VBZ cord-014516-r59usk02 1307 19 high high JJ cord-014516-r59usk02 1307 20 level level NN cord-014516-r59usk02 1307 21 resistance resistance NN cord-014516-r59usk02 1307 22 to to IN cord-014516-r59usk02 1307 23 aminoglycosides aminoglycoside NNS cord-014516-r59usk02 1307 24 ( ( -LRB- cord-014516-r59usk02 1307 25 7 7 CD cord-014516-r59usk02 1307 26 out out IN cord-014516-r59usk02 1307 27 of of IN cord-014516-r59usk02 1307 28 8 8 CD cord-014516-r59usk02 1307 29 isolates isolate NNS cord-014516-r59usk02 1307 30 ) ) -RRB- cord-014516-r59usk02 1307 31 . . . cord-014516-r59usk02 1308 1 In in IN cord-014516-r59usk02 1308 2 this this DT cord-014516-r59usk02 1308 3 study study NN cord-014516-r59usk02 1308 4 we -PRON- PRP cord-014516-r59usk02 1308 5 showed show VBD cord-014516-r59usk02 1308 6 that that IN cord-014516-r59usk02 1308 7 in in IN cord-014516-r59usk02 1308 8 the the DT cord-014516-r59usk02 1308 9 last last JJ cord-014516-r59usk02 1308 10 decade decade NN cord-014516-r59usk02 1308 11 the the DT cord-014516-r59usk02 1308 12 emergence emergence NN cord-014516-r59usk02 1308 13 of of IN cord-014516-r59usk02 1308 14 resistance resistance NN cord-014516-r59usk02 1308 15 to to TO cord-014516-r59usk02 1308 16 critically critically RB cord-014516-r59usk02 1308 17 important important JJ cord-014516-r59usk02 1308 18 antimicrobials antimicrobial NNS cord-014516-r59usk02 1308 19 among among IN cord-014516-r59usk02 1308 20 uropathogens uropathogen NNS cord-014516-r59usk02 1308 21 from from IN cord-014516-r59usk02 1308 22 companion companion NN cord-014516-r59usk02 1308 23 animals animal NNS cord-014516-r59usk02 1308 24 is be VBZ cord-014516-r59usk02 1308 25 a a DT cord-014516-r59usk02 1308 26 concerning concern VBG cord-014516-r59usk02 1308 27 fact fact NN cord-014516-r59usk02 1308 28 . . . cord-014516-r59usk02 1309 1 The the DT cord-014516-r59usk02 1309 2 multidrug multidrug NN cord-014516-r59usk02 1309 3 - - HYPH cord-014516-r59usk02 1309 4 resistant resistant JJ cord-014516-r59usk02 1309 5 Enterobacteriaceae Enterobacteriaceae NNP cord-014516-r59usk02 1309 6 may may MD cord-014516-r59usk02 1309 7 compromise compromise VB cord-014516-r59usk02 1309 8 effective effective JJ cord-014516-r59usk02 1309 9 therapeutic therapeutic JJ cord-014516-r59usk02 1309 10 options option NNS cord-014516-r59usk02 1309 11 , , , cord-014516-r59usk02 1309 12 namely namely RB cord-014516-r59usk02 1309 13 third third JJ cord-014516-r59usk02 1309 14 and and CC cord-014516-r59usk02 1309 15 fourth fourth JJ cord-014516-r59usk02 1309 16 generation generation NN cord-014516-r59usk02 1309 17 cephalosporins cephalosporin NNS cord-014516-r59usk02 1309 18 , , , cord-014516-r59usk02 1309 19 fluoroquinolones fluoroquinolone NNS cord-014516-r59usk02 1309 20 , , , cord-014516-r59usk02 1309 21 trimethoprim trimethoprim NNP cord-014516-r59usk02 1309 22 / / SYM cord-014516-r59usk02 1309 23 sulpha sulpha NNP cord-014516-r59usk02 1309 24 combinations combination NNS cord-014516-r59usk02 1309 25 . . . cord-014516-r59usk02 1310 1 The the DT cord-014516-r59usk02 1310 2 emergence emergence NN cord-014516-r59usk02 1310 3 of of IN cord-014516-r59usk02 1310 4 MRSA MRSA NNP cord-014516-r59usk02 1310 5 / / SYM cord-014516-r59usk02 1310 6 MRSP MRSP NNP cord-014516-r59usk02 1310 7 and and CC cord-014516-r59usk02 1310 8 HLGR HLGR NNP cord-014516-r59usk02 1310 9 among among IN cord-014516-r59usk02 1310 10 uropathogens uropathogen NNS cord-014516-r59usk02 1310 11 is be VBZ cord-014516-r59usk02 1310 12 also also RB cord-014516-r59usk02 1310 13 a a DT cord-014516-r59usk02 1310 14 therapeutic therapeutic JJ cord-014516-r59usk02 1310 15 challenge challenge NN cord-014516-r59usk02 1310 16 . . . cord-014516-r59usk02 1311 1 The the DT cord-014516-r59usk02 1311 2 detection detection NN cord-014516-r59usk02 1311 3 of of IN cord-014516-r59usk02 1311 4 uropathogens uropathogen NNS cord-014516-r59usk02 1311 5 with with IN cord-014516-r59usk02 1311 6 antimicrobial antimicrobial JJ cord-014516-r59usk02 1311 7 resistance resistance NN cord-014516-r59usk02 1311 8 is be VBZ cord-014516-r59usk02 1311 9 not not RB cord-014516-r59usk02 1311 10 only only RB cord-014516-r59usk02 1311 11 an an DT cord-014516-r59usk02 1311 12 animal animal NN cord-014516-r59usk02 1311 13 health health NN cord-014516-r59usk02 1311 14 issue issue NN cord-014516-r59usk02 1311 15 but but CC cord-014516-r59usk02 1311 16 also also RB cord-014516-r59usk02 1311 17 a a DT cord-014516-r59usk02 1311 18 matter matter NN cord-014516-r59usk02 1311 19 of of IN cord-014516-r59usk02 1311 20 public public JJ cord-014516-r59usk02 1311 21 health health NN cord-014516-r59usk02 1311 22 , , , cord-014516-r59usk02 1311 23 since since IN cord-014516-r59usk02 1311 24 companion companion NN cord-014516-r59usk02 1311 25 animals animal NNS cord-014516-r59usk02 1311 26 may may MD cord-014516-r59usk02 1311 27 act act VB cord-014516-r59usk02 1311 28 as as IN cord-014516-r59usk02 1311 29 reservoirs reservoir NNS cord-014516-r59usk02 1311 30 of of IN cord-014516-r59usk02 1311 31 antimicrobial antimicrobial JJ cord-014516-r59usk02 1311 32 resistant resistant JJ cord-014516-r59usk02 1311 33 bacteria bacteria NNS cord-014516-r59usk02 1311 34 or or CC cord-014516-r59usk02 1311 35 resistance resistance NN cord-014516-r59usk02 1311 36 genes gene NNS cord-014516-r59usk02 1311 37 for for IN cord-014516-r59usk02 1311 38 humans human NNS cord-014516-r59usk02 1311 39 . . . cord-014516-r59usk02 1312 1 The the DT cord-014516-r59usk02 1312 2 author author NN cord-014516-r59usk02 1312 3 currently currently RB cord-014516-r59usk02 1312 4 receives receive VBZ cord-014516-r59usk02 1312 5 a a DT cord-014516-r59usk02 1312 6 PhD phd NN cord-014516-r59usk02 1312 7 grant grant NN cord-014516-r59usk02 1312 8 funded fund VBN cord-014516-r59usk02 1312 9 by by IN cord-014516-r59usk02 1312 10 the the DT cord-014516-r59usk02 1312 11 Portuguese Portuguese NNP cord-014516-r59usk02 1312 12 Foundation Foundation NNP cord-014516-r59usk02 1312 13 for for IN cord-014516-r59usk02 1312 14 Science Science NNP cord-014516-r59usk02 1312 15 and and CC cord-014516-r59usk02 1312 16 Technology Technology NNP cord-014516-r59usk02 1312 17 . . . cord-014516-r59usk02 1313 1 In in IN cord-014516-r59usk02 1313 2 the the DT cord-014516-r59usk02 1313 3 past past NN cord-014516-r59usk02 1313 4 , , , cord-014516-r59usk02 1313 5 the the DT cord-014516-r59usk02 1313 6 author author NN cord-014516-r59usk02 1313 7 received receive VBD cord-014516-r59usk02 1313 8 once once RB cord-014516-r59usk02 1313 9 research research NN cord-014516-r59usk02 1313 10 support support NN cord-014516-r59usk02 1313 11 and and CC cord-014516-r59usk02 1313 12 honoraries honorarie NNS cord-014516-r59usk02 1313 13 from from IN cord-014516-r59usk02 1313 14 portuguese portuguese JJ cord-014516-r59usk02 1313 15 Merial Merial NNP cord-014516-r59usk02 1313 16 for for IN cord-014516-r59usk02 1313 17 a a DT cord-014516-r59usk02 1313 18 project project NN cord-014516-r59usk02 1313 19 on on IN cord-014516-r59usk02 1313 20 canine canine JJ cord-014516-r59usk02 1313 21 vector vector NN cord-014516-r59usk02 1313 22 borne bear VBN cord-014516-r59usk02 1313 23 diseases disease NNS cord-014516-r59usk02 1313 24 . . . cord-014516-r59usk02 1314 1 The the DT cord-014516-r59usk02 1314 2 aim aim NN cord-014516-r59usk02 1314 3 of of IN cord-014516-r59usk02 1314 4 the the DT cord-014516-r59usk02 1314 5 present present JJ cord-014516-r59usk02 1314 6 study study NN cord-014516-r59usk02 1314 7 was be VBD cord-014516-r59usk02 1314 8 to to TO cord-014516-r59usk02 1314 9 use use VB cord-014516-r59usk02 1314 10 insurance insurance NN cord-014516-r59usk02 1314 11 data datum NNS cord-014516-r59usk02 1314 12 to to TO cord-014516-r59usk02 1314 13 estimate estimate VB cord-014516-r59usk02 1314 14 morbidity morbidity NN cord-014516-r59usk02 1314 15 and and CC cord-014516-r59usk02 1314 16 mortality mortality NN cord-014516-r59usk02 1314 17 related relate VBN cord-014516-r59usk02 1314 18 to to IN cord-014516-r59usk02 1314 19 kidney kidney NN cord-014516-r59usk02 1314 20 disease disease NN cord-014516-r59usk02 1314 21 in in IN cord-014516-r59usk02 1314 22 the the DT cord-014516-r59usk02 1314 23 Swedish swedish JJ cord-014516-r59usk02 1314 24 dog dog NN cord-014516-r59usk02 1314 25 population population NN cord-014516-r59usk02 1314 26 . . . cord-014516-r59usk02 1315 1 Insurance insurance NN cord-014516-r59usk02 1315 2 company company NN cord-014516-r59usk02 1315 3 data datum NNS cord-014516-r59usk02 1315 4 from from IN cord-014516-r59usk02 1315 5 veterinary veterinary JJ cord-014516-r59usk02 1315 6 care care NN cord-014516-r59usk02 1315 7 - - HYPH cord-014516-r59usk02 1315 8 insured insure VBN cord-014516-r59usk02 1315 9 and and CC cord-014516-r59usk02 1315 10 lifeinsured lifeinsure VBN cord-014516-r59usk02 1315 11 dogs dog NNS cord-014516-r59usk02 1315 12 during during IN cord-014516-r59usk02 1315 13 the the DT cord-014516-r59usk02 1315 14 years year NNS cord-014516-r59usk02 1315 15 1995 1995 CD cord-014516-r59usk02 1315 16 - - SYM cord-014516-r59usk02 1315 17 2007 2007 CD cord-014516-r59usk02 1315 18 were be VBD cord-014516-r59usk02 1315 19 studied study VBN cord-014516-r59usk02 1315 20 retrospectively retrospectively RB cord-014516-r59usk02 1315 21 . . . cord-014516-r59usk02 1316 1 Incidence incidence NN cord-014516-r59usk02 1316 2 - - : cord-014516-r59usk02 1316 3 and and CC cord-014516-r59usk02 1316 4 mortality mortality NN cord-014516-r59usk02 1316 5 rates rate NNS cord-014516-r59usk02 1316 6 were be VBD cord-014516-r59usk02 1316 7 calculated calculate VBN cord-014516-r59usk02 1316 8 for for IN cord-014516-r59usk02 1316 9 the the DT cord-014516-r59usk02 1316 10 whole whole JJ cord-014516-r59usk02 1316 11 group group NN cord-014516-r59usk02 1316 12 of of IN cord-014516-r59usk02 1316 13 dogs dog NNS cord-014516-r59usk02 1316 14 as as RB cord-014516-r59usk02 1316 15 well well RB cord-014516-r59usk02 1316 16 as as IN cord-014516-r59usk02 1316 17 divided divide VBN cord-014516-r59usk02 1316 18 by by IN cord-014516-r59usk02 1316 19 sex sex NN cord-014516-r59usk02 1316 20 and and CC cord-014516-r59usk02 1316 21 breed breed NN cord-014516-r59usk02 1316 22 . . . cord-014516-r59usk02 1317 1 For for IN cord-014516-r59usk02 1317 2 the the DT cord-014516-r59usk02 1317 3 15 15 CD cord-014516-r59usk02 1317 4 breeds breed NNS cord-014516-r59usk02 1317 5 with with IN cord-014516-r59usk02 1317 6 the the DT cord-014516-r59usk02 1317 7 highest high JJS cord-014516-r59usk02 1317 8 incidence incidence NN cord-014516-r59usk02 1317 9 - - : cord-014516-r59usk02 1317 10 and and CC cord-014516-r59usk02 1317 11 mortality mortality NN cord-014516-r59usk02 1317 12 rates rate NNS cord-014516-r59usk02 1317 13 , , , cord-014516-r59usk02 1317 14 respectively respectively RB cord-014516-r59usk02 1317 15 , , , cord-014516-r59usk02 1317 16 the the DT cord-014516-r59usk02 1317 17 reasons reason NNS cord-014516-r59usk02 1317 18 for for IN cord-014516-r59usk02 1317 19 kidney kidney NN cord-014516-r59usk02 1317 20 disease disease NN cord-014516-r59usk02 1317 21 were be VBD cord-014516-r59usk02 1317 22 investigated investigate VBN cord-014516-r59usk02 1317 23 by by IN cord-014516-r59usk02 1317 24 dividing divide VBG cord-014516-r59usk02 1317 25 the the DT cord-014516-r59usk02 1317 26 diagnoses diagnosis NNS cord-014516-r59usk02 1317 27 into into IN cord-014516-r59usk02 1317 28 10 10 CD cord-014516-r59usk02 1317 29 ethiology ethiology NN cord-014516-r59usk02 1317 30 groups group NNS cord-014516-r59usk02 1317 31 . . . cord-014516-r59usk02 1318 1 The the DT cord-014516-r59usk02 1318 2 total total JJ cord-014516-r59usk02 1318 3 number number NN cord-014516-r59usk02 1318 4 of of IN cord-014516-r59usk02 1318 5 veterinary veterinary JJ cord-014516-r59usk02 1318 6 care care NN cord-014516-r59usk02 1318 7 - - HYPH cord-014516-r59usk02 1318 8 insured insure VBN cord-014516-r59usk02 1318 9 dogs dog NNS cord-014516-r59usk02 1318 10 was be VBD cord-014516-r59usk02 1318 11 665,245 665,245 CD cord-014516-r59usk02 1318 12 . . . cord-014516-r59usk02 1319 1 The the DT cord-014516-r59usk02 1319 2 total total JJ cord-014516-r59usk02 1319 3 incidence incidence NN cord-014516-r59usk02 1319 4 rate rate NN cord-014516-r59usk02 1319 5 of of IN cord-014516-r59usk02 1319 6 kidney kidney NN cord-014516-r59usk02 1319 7 disease disease NN cord-014516-r59usk02 1319 8 in in IN cord-014516-r59usk02 1319 9 this this DT cord-014516-r59usk02 1319 10 group group NN cord-014516-r59usk02 1319 11 of of IN cord-014516-r59usk02 1319 12 dogs dog NNS cord-014516-r59usk02 1319 13 was be VBD cord-014516-r59usk02 1319 14 15.7(15.3 15.7(15.3 CD cord-014516-r59usk02 1319 15 - - SYM cord-014516-r59usk02 1319 16 16.2 16.2 CD cord-014516-r59usk02 1319 17 ) ) -RRB- cord-014516-r59usk02 1319 18 cases/10,000 cases/10,000 NNP cord-014516-r59usk02 1319 19 dog dog NN cord-014516-r59usk02 1319 20 - - HYPH cord-014516-r59usk02 1319 21 years year NNS cord-014516-r59usk02 1319 22 at at IN cord-014516-r59usk02 1319 23 risk risk NN cord-014516-r59usk02 1319 24 . . . cord-014516-r59usk02 1320 1 The the DT cord-014516-r59usk02 1320 2 number number NN cord-014516-r59usk02 1320 3 of of IN cord-014516-r59usk02 1320 4 dogs dog NNS cord-014516-r59usk02 1320 5 in in IN cord-014516-r59usk02 1320 6 the the DT cord-014516-r59usk02 1320 7 life life NN cord-014516-r59usk02 1320 8 insurance insurance NN cord-014516-r59usk02 1320 9 was be VBD cord-014516-r59usk02 1320 10 548,346 548,346 CD cord-014516-r59usk02 1320 11 and and CC cord-014516-r59usk02 1321 1 in in IN cord-014516-r59usk02 1321 2 this this DT cord-014516-r59usk02 1321 3 group group NN cord-014516-r59usk02 1321 4 the the DT cord-014516-r59usk02 1321 5 total total JJ cord-014516-r59usk02 1321 6 kidney kidney NN cord-014516-r59usk02 1321 7 - - HYPH cord-014516-r59usk02 1321 8 related relate VBN cord-014516-r59usk02 1321 9 mortality mortality NN cord-014516-r59usk02 1321 10 rate rate NN cord-014516-r59usk02 1321 11 was be VBD cord-014516-r59usk02 1321 12 9.7(9.3 9.7(9.3 CD cord-014516-r59usk02 1321 13 - - SYM cord-014516-r59usk02 1321 14 10.2 10.2 CD cord-014516-r59usk02 1321 15 ) ) -RRB- cord-014516-r59usk02 1321 16 deaths/10,000 deaths/10,000 NNP cord-014516-r59usk02 1321 17 dogyears dogyear NNS cord-014516-r59usk02 1321 18 at at IN cord-014516-r59usk02 1321 19 risk risk NN cord-014516-r59usk02 1321 20 . . . cord-014516-r59usk02 1322 1 The the DT cord-014516-r59usk02 1322 2 2 2 CD cord-014516-r59usk02 1322 3 most most RBS cord-014516-r59usk02 1322 4 commonly commonly RB cord-014516-r59usk02 1322 5 reported report VBN cord-014516-r59usk02 1322 6 ethiologies ethiologie NNS cord-014516-r59usk02 1322 7 of of IN cord-014516-r59usk02 1322 8 kidney kidney NN cord-014516-r59usk02 1322 9 disease disease NN cord-014516-r59usk02 1322 10 were be VBD cord-014516-r59usk02 1322 11 " " `` cord-014516-r59usk02 1322 12 ethiology ethiology NNP cord-014516-r59usk02 1322 13 not not RB cord-014516-r59usk02 1322 14 determined"and determined"and VBP cord-014516-r59usk02 1322 15 " " `` cord-014516-r59usk02 1322 16 infectious/ infectious/ JJ cord-014516-r59usk02 1322 17 inflammatory inflammatory JJ cord-014516-r59usk02 1322 18 " " '' cord-014516-r59usk02 1322 19 . . . cord-014516-r59usk02 1323 1 The the DT cord-014516-r59usk02 1323 2 3 3 CD cord-014516-r59usk02 1323 3 breeds breed NNS cord-014516-r59usk02 1323 4 with with IN cord-014516-r59usk02 1323 5 the the DT cord-014516-r59usk02 1323 6 highest high JJS cord-014516-r59usk02 1323 7 incidence incidence NN cord-014516-r59usk02 1323 8 rate rate NN cord-014516-r59usk02 1323 9 of of IN cord-014516-r59usk02 1323 10 kidney kidney NN cord-014516-r59usk02 1323 11 disease disease NN cord-014516-r59usk02 1323 12 were be VBD cord-014516-r59usk02 1323 13 the the DT cord-014516-r59usk02 1323 14 Bernese bernese JJ cord-014516-r59usk02 1323 15 mountain mountain NN cord-014516-r59usk02 1323 16 dog dog NN cord-014516-r59usk02 1323 17 , , , cord-014516-r59usk02 1323 18 Miniature Miniature NNP cord-014516-r59usk02 1323 19 schnauzer schnauzer NN cord-014516-r59usk02 1323 20 and and CC cord-014516-r59usk02 1323 21 Boxer Boxer NNP cord-014516-r59usk02 1323 22 . . . cord-014516-r59usk02 1324 1 The the DT cord-014516-r59usk02 1324 2 3 3 CD cord-014516-r59usk02 1324 3 breeds breed NNS cord-014516-r59usk02 1324 4 with with IN cord-014516-r59usk02 1324 5 the the DT cord-014516-r59usk02 1324 6 highest high JJS cord-014516-r59usk02 1324 7 mortality mortality NN cord-014516-r59usk02 1324 8 caused cause VBN cord-014516-r59usk02 1324 9 by by IN cord-014516-r59usk02 1324 10 kidney kidney NN cord-014516-r59usk02 1324 11 disease disease NN cord-014516-r59usk02 1324 12 were be VBD cord-014516-r59usk02 1324 13 the the DT cord-014516-r59usk02 1324 14 Bernese bernese JJ cord-014516-r59usk02 1324 15 mountain mountain NN cord-014516-r59usk02 1324 16 dog dog NN cord-014516-r59usk02 1324 17 , , , cord-014516-r59usk02 1324 18 Shetland Shetland NNP cord-014516-r59usk02 1324 19 sheepdog sheepdog NN cord-014516-r59usk02 1324 20 and and CC cord-014516-r59usk02 1324 21 Flatcoated Flatcoated NNP cord-014516-r59usk02 1324 22 retriever retriever NN cord-014516-r59usk02 1324 23 . . . cord-014516-r59usk02 1325 1 In in IN cord-014516-r59usk02 1325 2 conclusion conclusion NN cord-014516-r59usk02 1325 3 , , , cord-014516-r59usk02 1325 4 the the DT cord-014516-r59usk02 1325 5 epidemiological epidemiological JJ cord-014516-r59usk02 1325 6 information information NN cord-014516-r59usk02 1325 7 provided provide VBN cord-014516-r59usk02 1325 8 in in IN cord-014516-r59usk02 1325 9 this this DT cord-014516-r59usk02 1325 10 study study NN cord-014516-r59usk02 1325 11 concerning concern VBG cord-014516-r59usk02 1325 12 kidney kidney NN cord-014516-r59usk02 1325 13 disease disease NN cord-014516-r59usk02 1325 14 in in IN cord-014516-r59usk02 1325 15 dogs dog NNS cord-014516-r59usk02 1325 16 can can MD cord-014516-r59usk02 1325 17 assist assist VB cord-014516-r59usk02 1325 18 clinicians clinician NNS cord-014516-r59usk02 1325 19 in in IN cord-014516-r59usk02 1325 20 establishing establish VBG cord-014516-r59usk02 1325 21 diagnoses diagnosis NNS cord-014516-r59usk02 1325 22 , , , cord-014516-r59usk02 1325 23 and and CC cord-014516-r59usk02 1325 24 can can MD cord-014516-r59usk02 1325 25 assist assist VB cord-014516-r59usk02 1325 26 breeders breeder NNS cord-014516-r59usk02 1325 27 in in IN cord-014516-r59usk02 1325 28 defining define VBG cord-014516-r59usk02 1325 29 priorities priority NNS cord-014516-r59usk02 1325 30 for for IN cord-014516-r59usk02 1325 31 preventative preventative JJ cord-014516-r59usk02 1325 32 measures measure NNS cord-014516-r59usk02 1325 33 . . . cord-014516-r59usk02 1326 1 It -PRON- PRP cord-014516-r59usk02 1326 2 can can MD cord-014516-r59usk02 1326 3 also also RB cord-014516-r59usk02 1326 4 provide provide VB cord-014516-r59usk02 1326 5 valuable valuable JJ cord-014516-r59usk02 1326 6 information information NN cord-014516-r59usk02 1326 7 for for IN cord-014516-r59usk02 1326 8 future future JJ cord-014516-r59usk02 1326 9 research research NN cord-014516-r59usk02 1326 10 . . . cord-014516-r59usk02 1327 1 The the DT cord-014516-r59usk02 1327 2 senior senior JJ cord-014516-r59usk02 1327 3 author author NN cord-014516-r59usk02 1327 4 has have VBZ cord-014516-r59usk02 1327 5 received receive VBN cord-014516-r59usk02 1327 6 money money NN cord-014516-r59usk02 1327 7 from from IN cord-014516-r59usk02 1327 8 the the DT cord-014516-r59usk02 1327 9 insurance insurance NN cord-014516-r59usk02 1327 10 company company NN cord-014516-r59usk02 1327 11 we -PRON- PRP cord-014516-r59usk02 1327 12 have have VBP cord-014516-r59usk02 1327 13 used use VBN cord-014516-r59usk02 1327 14 data datum NNS cord-014516-r59usk02 1327 15 from from IN cord-014516-r59usk02 1327 16 to to TO cord-014516-r59usk02 1327 17 write write VB cord-014516-r59usk02 1327 18 our -PRON- PRP$ cord-014516-r59usk02 1327 19 study study NN cord-014516-r59usk02 1327 20 , , , cord-014516-r59usk02 1327 21 for for IN cord-014516-r59usk02 1327 22 another another DT cord-014516-r59usk02 1327 23 project project NN cord-014516-r59usk02 1327 24 . . . cord-014516-r59usk02 1328 1 Jens Jens NNP cord-014516-r59usk02 1328 2 H€ h€ JJ cord-014516-r59usk02 1328 3 aggstr€ aggstr€ NN cord-014516-r59usk02 1328 4 om om NN cord-014516-r59usk02 1328 5 and and CC cord-014516-r59usk02 1328 6 Ingrid Ingrid NNP cord-014516-r59usk02 1328 7 Ljungvall Ljungvall NNP cord-014516-r59usk02 1328 8 have have VBP cord-014516-r59usk02 1328 9 received receive VBN cord-014516-r59usk02 1328 10 financial financial JJ cord-014516-r59usk02 1328 11 support support NN cord-014516-r59usk02 1328 12 for for IN cord-014516-r59usk02 1328 13 research research NN cord-014516-r59usk02 1328 14 from from IN cord-014516-r59usk02 1328 15 Sante Sante NNP cord-014516-r59usk02 1328 16 Animale Animale NNP cord-014516-r59usk02 1328 17 , , , cord-014516-r59usk02 1328 18 Agria Agria NNP cord-014516-r59usk02 1328 19 Insurance Insurance NNP cord-014516-r59usk02 1328 20 Ltd Ltd NNP cord-014516-r59usk02 1328 21 , , , cord-014516-r59usk02 1328 22 Sveland Sveland NNP cord-014516-r59usk02 1328 23 Insurance Insurance NNP cord-014516-r59usk02 1328 24 Ltd Ltd NNP cord-014516-r59usk02 1328 25 , , , cord-014516-r59usk02 1328 26 Forsgren Forsgren NNP cord-014516-r59usk02 1328 27 Research Research NNP cord-014516-r59usk02 1328 28 Foundation Foundation NNP cord-014516-r59usk02 1328 29 . . . cord-014516-r59usk02 1329 1 Both both DT cord-014516-r59usk02 1329 2 of of IN cord-014516-r59usk02 1329 3 these these DT cord-014516-r59usk02 1329 4 authors author NNS cord-014516-r59usk02 1329 5 have have VBP cord-014516-r59usk02 1329 6 also also RB cord-014516-r59usk02 1329 7 undertaken undertake VBN cord-014516-r59usk02 1329 8 paid pay VBN cord-014516-r59usk02 1329 9 consulatcny consulatcny NNS cord-014516-r59usk02 1329 10 work work VB cord-014516-r59usk02 1329 11 for for IN cord-014516-r59usk02 1329 12 Boehringer Boehringer NNP cord-014516-r59usk02 1329 13 - - HYPH cord-014516-r59usk02 1329 14 Ingelheim Ingelheim NNP cord-014516-r59usk02 1329 15 , , , cord-014516-r59usk02 1329 16 Ceva Ceva NNP cord-014516-r59usk02 1329 17 Sante Sante NNP cord-014516-r59usk02 1329 18 Animale Animale NNP cord-014516-r59usk02 1329 19 . . . cord-014516-r59usk02 1330 1 Mast mast JJ cord-014516-r59usk02 1330 2 cell cell NN cord-014516-r59usk02 1330 3 tumours tumour NNS cord-014516-r59usk02 1330 4 represent represent VBP cord-014516-r59usk02 1330 5 the the DT cord-014516-r59usk02 1330 6 most most RBS cord-014516-r59usk02 1330 7 common common JJ cord-014516-r59usk02 1330 8 cutaneous cutaneous JJ cord-014516-r59usk02 1330 9 tumour tumour NN cord-014516-r59usk02 1330 10 in in IN cord-014516-r59usk02 1330 11 the the DT cord-014516-r59usk02 1330 12 dog dog NN cord-014516-r59usk02 1330 13 . . . cord-014516-r59usk02 1331 1 Diagnosis diagnosis NN cord-014516-r59usk02 1331 2 of of IN cord-014516-r59usk02 1331 3 a a DT cord-014516-r59usk02 1331 4 mast mast JJ cord-014516-r59usk02 1331 5 cell cell NN cord-014516-r59usk02 1331 6 tumour tumour NN cord-014516-r59usk02 1331 7 can can MD cord-014516-r59usk02 1331 8 be be VB cord-014516-r59usk02 1331 9 achieved achieve VBN cord-014516-r59usk02 1331 10 through through IN cord-014516-r59usk02 1331 11 cytological cytological JJ cord-014516-r59usk02 1331 12 examination examination NN cord-014516-r59usk02 1331 13 of of IN cord-014516-r59usk02 1331 14 fine fine JJ cord-014516-r59usk02 1331 15 needle needle NN cord-014516-r59usk02 1331 16 aspirate aspirate NN cord-014516-r59usk02 1331 17 . . . cord-014516-r59usk02 1332 1 However however RB cord-014516-r59usk02 1332 2 the the DT cord-014516-r59usk02 1332 3 grade grade NN cord-014516-r59usk02 1332 4 of of IN cord-014516-r59usk02 1332 5 the the DT cord-014516-r59usk02 1332 6 tumour tumour NN cord-014516-r59usk02 1332 7 is be VBZ cord-014516-r59usk02 1332 8 an an DT cord-014516-r59usk02 1332 9 important important JJ cord-014516-r59usk02 1332 10 prognostic prognostic JJ cord-014516-r59usk02 1332 11 marker marker NN cord-014516-r59usk02 1332 12 and and CC cord-014516-r59usk02 1332 13 requires require VBZ cord-014516-r59usk02 1332 14 so so RB cord-014516-r59usk02 1332 15 far far JJ cord-014516-r59usk02 1332 16 histologic histologic JJ cord-014516-r59usk02 1332 17 assessment assessment NN cord-014516-r59usk02 1332 18 . . . cord-014516-r59usk02 1333 1 A a DT cord-014516-r59usk02 1333 2 2-tier 2-tier JJ cord-014516-r59usk02 1333 3 histologic histologic JJ cord-014516-r59usk02 1333 4 grading grading NN cord-014516-r59usk02 1333 5 system system NN cord-014516-r59usk02 1333 6 based base VBN cord-014516-r59usk02 1333 7 on on IN cord-014516-r59usk02 1333 8 number number NN cord-014516-r59usk02 1333 9 of of IN cord-014516-r59usk02 1333 10 mitoses mitose NNS cord-014516-r59usk02 1333 11 , , , cord-014516-r59usk02 1333 12 multinucleated multinucleate VBN cord-014516-r59usk02 1333 13 cells cell NNS cord-014516-r59usk02 1333 14 , , , cord-014516-r59usk02 1333 15 bizarre bizarre JJ cord-014516-r59usk02 1333 16 nuclei nucleus NNS cord-014516-r59usk02 1333 17 and and CC cord-014516-r59usk02 1333 18 karyomegaly karyomegaly NNP cord-014516-r59usk02 1333 19 was be VBD cord-014516-r59usk02 1333 20 recently recently RB cord-014516-r59usk02 1333 21 proposed propose VBN cord-014516-r59usk02 1333 22 by by IN cord-014516-r59usk02 1333 23 Kiupel Kiupel NNP cord-014516-r59usk02 1333 24 et et NNP cord-014516-r59usk02 1333 25 al al NNP cord-014516-r59usk02 1333 26 . . . cord-014516-r59usk02 1334 1 The the DT cord-014516-r59usk02 1334 2 aim aim NN cord-014516-r59usk02 1334 3 of of IN cord-014516-r59usk02 1334 4 this this DT cord-014516-r59usk02 1334 5 study study NN cord-014516-r59usk02 1334 6 was be VBD cord-014516-r59usk02 1334 7 to to TO cord-014516-r59usk02 1334 8 assess assess VB cord-014516-r59usk02 1334 9 if if IN cord-014516-r59usk02 1334 10 the the DT cord-014516-r59usk02 1334 11 cytomorphological cytomorphological JJ cord-014516-r59usk02 1334 12 criteria criterion NNS cord-014516-r59usk02 1334 13 proposed propose VBN cord-014516-r59usk02 1334 14 in in IN cord-014516-r59usk02 1334 15 the the DT cord-014516-r59usk02 1334 16 2-tier 2-tier JJ cord-014516-r59usk02 1334 17 histologic histologic JJ cord-014516-r59usk02 1334 18 grading grading NN cord-014516-r59usk02 1334 19 system system NN cord-014516-r59usk02 1334 20 are be VBP cord-014516-r59usk02 1334 21 applicable applicable JJ cord-014516-r59usk02 1334 22 on on IN cord-014516-r59usk02 1334 23 cytology cytology NN cord-014516-r59usk02 1334 24 specimens specimen NNS cord-014516-r59usk02 1334 25 . . . cord-014516-r59usk02 1335 1 Ninety ninety CD cord-014516-r59usk02 1335 2 - - HYPH cord-014516-r59usk02 1335 3 three three CD cord-014516-r59usk02 1335 4 mast mast JJ cord-014516-r59usk02 1335 5 cell cell NN cord-014516-r59usk02 1335 6 tumour tumour NN cord-014516-r59usk02 1335 7 specimens specimen NNS cord-014516-r59usk02 1335 8 of of IN cord-014516-r59usk02 1335 9 grade grade NN cord-014516-r59usk02 1335 10 I -PRON- PRP cord-014516-r59usk02 1335 11 or or CC cord-014516-r59usk02 1335 12 grade grade NN cord-014516-r59usk02 1335 13 III III NNP cord-014516-r59usk02 1335 14 according accord VBG cord-014516-r59usk02 1335 15 to to IN cord-014516-r59usk02 1335 16 Patnaik Patnaik NNP cord-014516-r59usk02 1335 17 with with IN cord-014516-r59usk02 1335 18 both both DT cord-014516-r59usk02 1335 19 histological histological JJ cord-014516-r59usk02 1335 20 specimens specimen NNS cord-014516-r59usk02 1335 21 and and CC cord-014516-r59usk02 1335 22 fine fine JJ cord-014516-r59usk02 1335 23 needle needle NN cord-014516-r59usk02 1335 24 aspirates aspirate NNS cord-014516-r59usk02 1335 25 were be VBD cord-014516-r59usk02 1335 26 retrospectively retrospectively RB cord-014516-r59usk02 1335 27 taken take VBN cord-014516-r59usk02 1335 28 from from IN cord-014516-r59usk02 1335 29 a a DT cord-014516-r59usk02 1335 30 data data NN cord-014516-r59usk02 1335 31 set set VBN cord-014516-r59usk02 1335 32 and and CC cord-014516-r59usk02 1335 33 histologically histologically RB cord-014516-r59usk02 1335 34 and and CC cord-014516-r59usk02 1335 35 cytologically cytologically RB cord-014516-r59usk02 1335 36 re re VBD cord-014516-r59usk02 1335 37 - - VBN cord-014516-r59usk02 1335 38 evaluated evaluate VBN cord-014516-r59usk02 1335 39 . . . cord-014516-r59usk02 1336 1 According accord VBG cord-014516-r59usk02 1336 2 to to IN cord-014516-r59usk02 1336 3 the the DT cord-014516-r59usk02 1336 4 Kiupel Kiupel NNP cord-014516-r59usk02 1336 5 grading grading NN cord-014516-r59usk02 1336 6 system system NN cord-014516-r59usk02 1336 7 thirty thirty CD cord-014516-r59usk02 1336 8 - - HYPH cord-014516-r59usk02 1336 9 six six CD cord-014516-r59usk02 1336 10 were be VBD cord-014516-r59usk02 1336 11 diagnosed diagnose VBN cord-014516-r59usk02 1336 12 histologically histologically RB cord-014516-r59usk02 1336 13 as as IN cord-014516-r59usk02 1336 14 high high JJ cord-014516-r59usk02 1336 15 grades grade NNS cord-014516-r59usk02 1336 16 and and CC cord-014516-r59usk02 1336 17 fifty fifty CD cord-014516-r59usk02 1336 18 - - HYPH cord-014516-r59usk02 1336 19 seven seven CD cord-014516-r59usk02 1336 20 were be VBD cord-014516-r59usk02 1336 21 considered consider VBN cord-014516-r59usk02 1336 22 low low JJ cord-014516-r59usk02 1336 23 - - HYPH cord-014516-r59usk02 1336 24 grade grade NN cord-014516-r59usk02 1336 25 mast mast JJ cord-014516-r59usk02 1336 26 cell cell NN cord-014516-r59usk02 1336 27 tumours tumour NNS cord-014516-r59usk02 1336 28 . . . cord-014516-r59usk02 1337 1 The the DT cord-014516-r59usk02 1337 2 cytologic cytologic JJ cord-014516-r59usk02 1337 3 examination examination NN cord-014516-r59usk02 1337 4 of of IN cord-014516-r59usk02 1337 5 the the DT cord-014516-r59usk02 1337 6 corresponding correspond VBG cord-014516-r59usk02 1337 7 specimens specimen NNS cord-014516-r59usk02 1337 8 revealed reveal VBD cord-014516-r59usk02 1337 9 thirty thirty CD cord-014516-r59usk02 1337 10 - - HYPH cord-014516-r59usk02 1337 11 one one CD cord-014516-r59usk02 1337 12 high high JJ cord-014516-r59usk02 1337 13 grade grade NN cord-014516-r59usk02 1337 14 and and CC cord-014516-r59usk02 1337 15 fifty fifty CD cord-014516-r59usk02 1337 16 - - HYPH cord-014516-r59usk02 1337 17 five five CD cord-014516-r59usk02 1337 18 low low JJ cord-014516-r59usk02 1337 19 - - HYPH cord-014516-r59usk02 1337 20 grade grade NN cord-014516-r59usk02 1337 21 tumours tumour NNS cord-014516-r59usk02 1337 22 . . . cord-014516-r59usk02 1338 1 An an DT cord-014516-r59usk02 1338 2 agreement agreement NN cord-014516-r59usk02 1338 3 between between IN cord-014516-r59usk02 1338 4 histologic histologic JJ cord-014516-r59usk02 1338 5 and and CC cord-014516-r59usk02 1338 6 cytologic cytologic JJ cord-014516-r59usk02 1338 7 diagnosis diagnosis NN cord-014516-r59usk02 1338 8 based base VBN cord-014516-r59usk02 1338 9 on on IN cord-014516-r59usk02 1338 10 the the DT cord-014516-r59usk02 1338 11 Kiupel Kiupel NNP cord-014516-r59usk02 1338 12 grading grading NN cord-014516-r59usk02 1338 13 system system NN cord-014516-r59usk02 1338 14 was be VBD cord-014516-r59usk02 1338 15 achieved achieve VBN cord-014516-r59usk02 1338 16 in in IN cord-014516-r59usk02 1338 17 eighty eighty CD cord-014516-r59usk02 1338 18 - - HYPH cord-014516-r59usk02 1338 19 six six CD cord-014516-r59usk02 1338 20 cases case NNS cord-014516-r59usk02 1338 21 ( ( -LRB- cord-014516-r59usk02 1338 22 accuracy accuracy NN cord-014516-r59usk02 1338 23 92.4 92.4 CD cord-014516-r59usk02 1338 24 % % NN cord-014516-r59usk02 1338 25 , , , cord-014516-r59usk02 1338 26 specificity specificity NN cord-014516-r59usk02 1338 27 93.9 93.9 CD cord-014516-r59usk02 1338 28 % % NN cord-014516-r59usk02 1338 29 , , , cord-014516-r59usk02 1338 30 sensitivity sensitivity NN cord-014516-r59usk02 1338 31 91.6 91.6 CD cord-014516-r59usk02 1338 32 % % NN cord-014516-r59usk02 1338 33 ) ) -RRB- cord-014516-r59usk02 1338 34 . . . cord-014516-r59usk02 1339 1 Five five CD cord-014516-r59usk02 1339 2 high high JJ cord-014516-r59usk02 1339 3 - - HYPH cord-014516-r59usk02 1339 4 grade grade NN cord-014516-r59usk02 1339 5 tumours tumour NNS cord-014516-r59usk02 1339 6 ( ( -LRB- cord-014516-r59usk02 1339 7 13.8 13.8 CD cord-014516-r59usk02 1339 8 % % NN cord-014516-r59usk02 1339 9 ) ) -RRB- cord-014516-r59usk02 1339 10 were be VBD cord-014516-r59usk02 1339 11 considered consider VBN cord-014516-r59usk02 1339 12 as as IN cord-014516-r59usk02 1339 13 low low JJ cord-014516-r59usk02 1339 14 grade grade NN cord-014516-r59usk02 1339 15 on on IN cord-014516-r59usk02 1339 16 cytology cytology NN cord-014516-r59usk02 1339 17 . . . cord-014516-r59usk02 1340 1 Cytologic cytologic JJ cord-014516-r59usk02 1340 2 grading grading NN cord-014516-r59usk02 1340 3 of of IN cord-014516-r59usk02 1340 4 mast mast JJ cord-014516-r59usk02 1340 5 cell cell NN cord-014516-r59usk02 1340 6 tumours tumour NNS cord-014516-r59usk02 1340 7 in in IN cord-014516-r59usk02 1340 8 the the DT cord-014516-r59usk02 1340 9 dog dog NN cord-014516-r59usk02 1340 10 has have VBZ cord-014516-r59usk02 1340 11 satisfactory satisfactory JJ cord-014516-r59usk02 1340 12 accuracy accuracy NN cord-014516-r59usk02 1340 13 , , , cord-014516-r59usk02 1340 14 sensitivity sensitivity NN cord-014516-r59usk02 1340 15 , , , cord-014516-r59usk02 1340 16 and and CC cord-014516-r59usk02 1340 17 specificity specificity NN cord-014516-r59usk02 1340 18 . . . cord-014516-r59usk02 1341 1 Histologic Histologic NNP cord-014516-r59usk02 1341 2 grading grading NN cord-014516-r59usk02 1341 3 of of IN cord-014516-r59usk02 1341 4 canine canine JJ cord-014516-r59usk02 1341 5 mast mast NN cord-014516-r59usk02 1341 6 cell cell NN cord-014516-r59usk02 1341 7 tumours tumour NNS cord-014516-r59usk02 1341 8 still still RB cord-014516-r59usk02 1341 9 remains remain VBZ cord-014516-r59usk02 1341 10 the the DT cord-014516-r59usk02 1341 11 gold gold NN cord-014516-r59usk02 1341 12 standard standard NN cord-014516-r59usk02 1341 13 , , , cord-014516-r59usk02 1341 14 but but CC cord-014516-r59usk02 1341 15 cytology cytology NN cord-014516-r59usk02 1341 16 already already RB cord-014516-r59usk02 1341 17 gives give VBZ cord-014516-r59usk02 1341 18 reliable reliable JJ cord-014516-r59usk02 1341 19 information information NN cord-014516-r59usk02 1341 20 . . . cord-014516-r59usk02 1342 1 No no DT cord-014516-r59usk02 1342 2 conflicts conflict NNS cord-014516-r59usk02 1342 3 of of IN cord-014516-r59usk02 1342 4 interest interest NN cord-014516-r59usk02 1342 5 reported report VBN cord-014516-r59usk02 1342 6 . . . cord-014516-r59usk02 1343 1 In in IN cord-014516-r59usk02 1343 2 canines canine NNS cord-014516-r59usk02 1343 3 mastocytomas mastocytoma NNS cord-014516-r59usk02 1343 4 are be VBP cord-014516-r59usk02 1343 5 among among IN cord-014516-r59usk02 1343 6 the the DT cord-014516-r59usk02 1343 7 most most RBS cord-014516-r59usk02 1343 8 frequently frequently RB cord-014516-r59usk02 1343 9 diagnosed diagnose VBN cord-014516-r59usk02 1343 10 neoplasms neoplasm NNS cord-014516-r59usk02 1343 11 of of IN cord-014516-r59usk02 1343 12 the the DT cord-014516-r59usk02 1343 13 skin skin NN cord-014516-r59usk02 1343 14 . . . cord-014516-r59usk02 1344 1 High high JJ cord-014516-r59usk02 1344 2 grade grade NN cord-014516-r59usk02 1344 3 mastocytomas mastocytomas NN cord-014516-r59usk02 1344 4 ( ( -LRB- cord-014516-r59usk02 1344 5 grade grade NN cord-014516-r59usk02 1344 6 III III NNP cord-014516-r59usk02 1344 7 , , , cord-014516-r59usk02 1344 8 Patnaik Patnaik NNP cord-014516-r59usk02 1344 9 classification classification NN cord-014516-r59usk02 1344 10 ) ) -RRB- cord-014516-r59usk02 1344 11 are be VBP cord-014516-r59usk02 1344 12 characterized characterize VBN cord-014516-r59usk02 1344 13 by by IN cord-014516-r59usk02 1344 14 an an DT cord-014516-r59usk02 1344 15 uncontrolled uncontrolled JJ cord-014516-r59usk02 1344 16 growth growth NN cord-014516-r59usk02 1344 17 of of IN cord-014516-r59usk02 1344 18 neoplastic neoplastic JJ cord-014516-r59usk02 1344 19 mast mast NN cord-014516-r59usk02 1344 20 cells cell NNS cord-014516-r59usk02 1344 21 ( ( -LRB- cord-014516-r59usk02 1344 22 MC MC NNP cord-014516-r59usk02 1344 23 ) ) -RRB- cord-014516-r59usk02 1344 24 and and CC cord-014516-r59usk02 1344 25 a a DT cord-014516-r59usk02 1344 26 poor poor JJ cord-014516-r59usk02 1344 27 prognosis prognosis NN cord-014516-r59usk02 1344 28 . . . cord-014516-r59usk02 1345 1 Recently recently RB cord-014516-r59usk02 1345 2 , , , cord-014516-r59usk02 1345 3 the the DT cord-014516-r59usk02 1345 4 KIT kit NN cord-014516-r59usk02 1345 5 - - HYPH cord-014516-r59usk02 1345 6 targeting target VBG cord-014516-r59usk02 1345 7 tyrosine tyrosine NN cord-014516-r59usk02 1345 8 kinase kinase NN cord-014516-r59usk02 1345 9 inhibitors inhibitor NNS cord-014516-r59usk02 1345 10 masitinib masitinib VBP cord-014516-r59usk02 1345 11 and and CC cord-014516-r59usk02 1345 12 toceranib toceranib NN cord-014516-r59usk02 1345 13 have have VBP cord-014516-r59usk02 1345 14 been be VBN cord-014516-r59usk02 1345 15 approved approve VBN cord-014516-r59usk02 1345 16 for for IN cord-014516-r59usk02 1345 17 the the DT cord-014516-r59usk02 1345 18 treatment treatment NN cord-014516-r59usk02 1345 19 of of IN cord-014516-r59usk02 1345 20 canine canine JJ cord-014516-r59usk02 1345 21 MC MC NNP cord-014516-r59usk02 1345 22 tumors tumor NNS cord-014516-r59usk02 1345 23 . . . cord-014516-r59usk02 1346 1 These these DT cord-014516-r59usk02 1346 2 drugs drug NNS cord-014516-r59usk02 1346 3 are be VBP cord-014516-r59usk02 1346 4 able able JJ cord-014516-r59usk02 1346 5 to to TO cord-014516-r59usk02 1346 6 induce induce VB cord-014516-r59usk02 1346 7 responses response NNS cord-014516-r59usk02 1346 8 in in IN cord-014516-r59usk02 1346 9 mastocytoma mastocytoma NNP cord-014516-r59usk02 1346 10 patients patient NNS cord-014516-r59usk02 1346 11 . . . cord-014516-r59usk02 1347 1 However however RB cord-014516-r59usk02 1347 2 , , , cord-014516-r59usk02 1347 3 in in IN cord-014516-r59usk02 1347 4 many many JJ cord-014516-r59usk02 1347 5 patients patient NNS cord-014516-r59usk02 1347 6 , , , cord-014516-r59usk02 1347 7 relapses relapse NNS cord-014516-r59usk02 1347 8 are be VBP cord-014516-r59usk02 1347 9 seen see VBN cord-014516-r59usk02 1347 10 . . . cord-014516-r59usk02 1348 1 Therefore therefore RB cord-014516-r59usk02 1348 2 , , , cord-014516-r59usk02 1348 3 research research NN cord-014516-r59usk02 1348 4 is be VBZ cord-014516-r59usk02 1348 5 focusing focus VBG cord-014516-r59usk02 1348 6 on on IN cord-014516-r59usk02 1348 7 new new JJ cord-014516-r59usk02 1348 8 drug drug NN cord-014516-r59usk02 1348 9 targets target NNS cord-014516-r59usk02 1348 10 . . . cord-014516-r59usk02 1349 1 Recently recently RB cord-014516-r59usk02 1349 2 , , , cord-014516-r59usk02 1349 3 the the DT cord-014516-r59usk02 1349 4 transcription transcription NN cord-014516-r59usk02 1349 5 factor factor NN cord-014516-r59usk02 1349 6 STAT5 stat5 RB cord-014516-r59usk02 1349 7 has have VBZ cord-014516-r59usk02 1349 8 been be VBN cord-014516-r59usk02 1349 9 reported report VBN cord-014516-r59usk02 1349 10 to to TO cord-014516-r59usk02 1349 11 play play VB cord-014516-r59usk02 1349 12 an an DT cord-014516-r59usk02 1349 13 important important JJ cord-014516-r59usk02 1349 14 role role NN cord-014516-r59usk02 1349 15 in in IN cord-014516-r59usk02 1349 16 the the DT cord-014516-r59usk02 1349 17 proliferation proliferation NN cord-014516-r59usk02 1349 18 and and CC cord-014516-r59usk02 1349 19 survival survival NN cord-014516-r59usk02 1349 20 of of IN cord-014516-r59usk02 1349 21 human human JJ cord-014516-r59usk02 1349 22 neoplastic neoplastic JJ cord-014516-r59usk02 1349 23 MC MC NNP cord-014516-r59usk02 1349 24 . . . cord-014516-r59usk02 1350 1 The the DT cord-014516-r59usk02 1350 2 aim aim NN cord-014516-r59usk02 1350 3 of of IN cord-014516-r59usk02 1350 4 the the DT cord-014516-r59usk02 1350 5 present present JJ cord-014516-r59usk02 1350 6 study study NN cord-014516-r59usk02 1350 7 was be VBD cord-014516-r59usk02 1350 8 to to TO cord-014516-r59usk02 1350 9 evaluate evaluate VB cord-014516-r59usk02 1350 10 the the DT cord-014516-r59usk02 1350 11 JAK2-STAT5 JAK2-STAT5 NNP cord-014516-r59usk02 1350 12 pathway pathway NN cord-014516-r59usk02 1350 13 in in IN cord-014516-r59usk02 1350 14 canine canine JJ cord-014516-r59usk02 1350 15 mastocytomas mastocytomas NN cord-014516-r59usk02 1350 16 . . . cord-014516-r59usk02 1351 1 To to TO cord-014516-r59usk02 1351 2 address address VB cord-014516-r59usk02 1351 3 this this DT cord-014516-r59usk02 1351 4 aim aim NN cord-014516-r59usk02 1351 5 , , , cord-014516-r59usk02 1351 6 the the DT cord-014516-r59usk02 1351 7 canine canine JJ cord-014516-r59usk02 1351 8 mastocytoma mastocytoma NNP cord-014516-r59usk02 1351 9 cell cell NN cord-014516-r59usk02 1351 10 lines line NNS cord-014516-r59usk02 1351 11 C2 C2 NNP cord-014516-r59usk02 1351 12 and and CC cord-014516-r59usk02 1351 13 NI-1 NI-1 NNP cord-014516-r59usk02 1351 14 as as RB cord-014516-r59usk02 1351 15 well well RB cord-014516-r59usk02 1351 16 as as IN cord-014516-r59usk02 1351 17 inhibitors inhibitor NNS cord-014516-r59usk02 1351 18 directed direct VBD cord-014516-r59usk02 1351 19 against against IN cord-014516-r59usk02 1351 20 JAK2 JAK2 NNP cord-014516-r59usk02 1351 21 or or CC cord-014516-r59usk02 1351 22 STAT5 STAT5 NNP cord-014516-r59usk02 1351 23 were be VBD cord-014516-r59usk02 1351 24 employed employ VBN cord-014516-r59usk02 1351 25 . . . cord-014516-r59usk02 1352 1 As as IN cord-014516-r59usk02 1352 2 assessed assess VBN cord-014516-r59usk02 1352 3 by by IN cord-014516-r59usk02 1352 4 immunocytochemistry immunocytochemistry NNP cord-014516-r59usk02 1352 5 , , , cord-014516-r59usk02 1352 6 C2 C2 NNP cord-014516-r59usk02 1352 7 cells cell NNS cord-014516-r59usk02 1352 8 and and CC cord-014516-r59usk02 1352 9 NI-1 NI-1 NNP cord-014516-r59usk02 1352 10 cells cell NNS cord-014516-r59usk02 1352 11 were be VBD cord-014516-r59usk02 1352 12 found find VBN cord-014516-r59usk02 1352 13 to to TO cord-014516-r59usk02 1352 14 express express VB cord-014516-r59usk02 1352 15 pSTAT5 pSTAT5 NNP cord-014516-r59usk02 1352 16 in in IN cord-014516-r59usk02 1352 17 their -PRON- PRP$ cord-014516-r59usk02 1352 18 cytoplasm cytoplasm NN cord-014516-r59usk02 1352 19 and and CC cord-014516-r59usk02 1352 20 nuclei nucleus NNS cord-014516-r59usk02 1352 21 . . . cord-014516-r59usk02 1353 1 Intracellular intracellular JJ cord-014516-r59usk02 1353 2 expression expression NN cord-014516-r59usk02 1353 3 of of IN cord-014516-r59usk02 1353 4 pSTAT5 pSTAT5 NNP cord-014516-r59usk02 1353 5 was be VBD cord-014516-r59usk02 1353 6 confirmed confirm VBN cord-014516-r59usk02 1353 7 by by IN cord-014516-r59usk02 1353 8 flow flow NN cord-014516-r59usk02 1353 9 cytometry cytometry NN cord-014516-r59usk02 1353 10 . . . cord-014516-r59usk02 1354 1 Interestingly interestingly RB cord-014516-r59usk02 1354 2 , , , cord-014516-r59usk02 1354 3 C2 c2 NN cord-014516-r59usk02 1354 4 cells cell NNS cord-014516-r59usk02 1354 5 were be VBD cord-014516-r59usk02 1354 6 found find VBN cord-014516-r59usk02 1354 7 to to TO cord-014516-r59usk02 1354 8 express express VB cord-014516-r59usk02 1354 9 higher high JJR cord-014516-r59usk02 1354 10 levels level NNS cord-014516-r59usk02 1354 11 of of IN cord-014516-r59usk02 1354 12 pSTAT5 pstat5 CD cord-014516-r59usk02 1354 13 compared compare VBN cord-014516-r59usk02 1354 14 to to IN cord-014516-r59usk02 1354 15 NI-1 NI-1 NNP cord-014516-r59usk02 1354 16 cells cell NNS cord-014516-r59usk02 1354 17 . . . cord-014516-r59usk02 1355 1 Next next RB cord-014516-r59usk02 1355 2 , , , cord-014516-r59usk02 1355 3 we -PRON- PRP cord-014516-r59usk02 1355 4 treated treat VBD cord-014516-r59usk02 1355 5 C2 C2 NNP cord-014516-r59usk02 1355 6 cells cell NNS cord-014516-r59usk02 1355 7 and and CC cord-014516-r59usk02 1355 8 NI-1 NI-1 NNP cord-014516-r59usk02 1355 9 cells cell NNS cord-014516-r59usk02 1355 10 with with IN cord-014516-r59usk02 1355 11 various various JJ cord-014516-r59usk02 1355 12 concentrations concentration NNS cord-014516-r59usk02 1355 13 of of IN cord-014516-r59usk02 1355 14 the the DT cord-014516-r59usk02 1355 15 STAT5 STAT5 NNP cord-014516-r59usk02 1355 16 inhibitors inhibitor NNS cord-014516-r59usk02 1355 17 piceatannol piceatannol NN cord-014516-r59usk02 1355 18 and and CC cord-014516-r59usk02 1355 19 pimozide pimozide NN cord-014516-r59usk02 1355 20 and and CC cord-014516-r59usk02 1355 21 the the DT cord-014516-r59usk02 1355 22 JAK2 JAK2 NNP cord-014516-r59usk02 1355 23 inhibitors inhibitor NNS cord-014516-r59usk02 1355 24 AZD1480 AZD1480 VBZ cord-014516-r59usk02 1355 25 and and CC cord-014516-r59usk02 1355 26 TG101348 TG101348 NNP cord-014516-r59usk02 1355 27 . . . cord-014516-r59usk02 1356 1 As as IN cord-014516-r59usk02 1356 2 assessed assess VBN cord-014516-r59usk02 1356 3 by by IN cord-014516-r59usk02 1356 4 3 3 CD cord-014516-r59usk02 1356 5 H h NN cord-014516-r59usk02 1356 6 - - HYPH cord-014516-r59usk02 1356 7 thymidine thymidine NN cord-014516-r59usk02 1356 8 uptake uptake NN cord-014516-r59usk02 1356 9 , , , cord-014516-r59usk02 1356 10 all all DT cord-014516-r59usk02 1356 11 4 4 CD cord-014516-r59usk02 1356 12 compounds compound NNS cord-014516-r59usk02 1356 13 were be VBD cord-014516-r59usk02 1356 14 found find VBN cord-014516-r59usk02 1356 15 to to TO cord-014516-r59usk02 1356 16 inhibit inhibit VB cord-014516-r59usk02 1356 17 the the DT cord-014516-r59usk02 1356 18 proliferation proliferation NN cord-014516-r59usk02 1356 19 of of IN cord-014516-r59usk02 1356 20 canine canine JJ cord-014516-r59usk02 1356 21 MC MC NNP cord-014516-r59usk02 1356 22 in in IN cord-014516-r59usk02 1356 23 a a DT cord-014516-r59usk02 1356 24 dose dose NN cord-014516-r59usk02 1356 25 - - HYPH cord-014516-r59usk02 1356 26 dependent dependent JJ cord-014516-r59usk02 1356 27 manner manner NN cord-014516-r59usk02 1356 28 . . . cord-014516-r59usk02 1357 1 Drug drug NN cord-014516-r59usk02 1357 2 effects effect NNS cord-014516-r59usk02 1357 3 were be VBD cord-014516-r59usk02 1357 4 found find VBN cord-014516-r59usk02 1357 5 to to TO cord-014516-r59usk02 1357 6 vary vary VB cord-014516-r59usk02 1357 7 in in IN cord-014516-r59usk02 1357 8 different different JJ cord-014516-r59usk02 1357 9 cell cell NN cord-014516-r59usk02 1357 10 lines line NNS cord-014516-r59usk02 1357 11 , , , cord-014516-r59usk02 1357 12 with with IN cord-014516-r59usk02 1357 13 the the DT cord-014516-r59usk02 1357 14 following following JJ cord-014516-r59usk02 1357 15 rank rank NN cord-014516-r59usk02 1357 16 - - HYPH cord-014516-r59usk02 1357 17 order order NN cord-014516-r59usk02 1357 18 of of IN cord-014516-r59usk02 1357 19 potency potency NN cord-014516-r59usk02 1357 20 ( ( -LRB- cord-014516-r59usk02 1357 21 IC IC NNP cord-014516-r59usk02 1357 22 50 50 CD cord-014516-r59usk02 1357 23 values value NNS cord-014516-r59usk02 1357 24 ) ) -RRB- cord-014516-r59usk02 1357 25 : : : cord-014516-r59usk02 1358 1 TG101348 tg101348 RB cord-014516-r59usk02 1358 2 : : : cord-014516-r59usk02 1358 3 0.1 0.1 CD cord-014516-r59usk02 1358 4 - - HYPH cord-014516-r59usk02 1358 5 0.75 0.75 CD cord-014516-r59usk02 1358 6 lM lm NN cord-014516-r59usk02 1358 7 ; ; . cord-014516-r59usk02 1359 1 pimozide pimozide NNP cord-014516-r59usk02 1359 2 : : : cord-014516-r59usk02 1359 3 0.1 0.1 CD cord-014516-r59usk02 1359 4 - - SYM cord-014516-r59usk02 1359 5 2.5 2.5 CD cord-014516-r59usk02 1359 6 lM lm NN cord-014516-r59usk02 1359 7 ; ; . cord-014516-r59usk02 1360 1 AZD1480 AZD1480 NNP cord-014516-r59usk02 1360 2 : : : cord-014516-r59usk02 1360 3 1 1 CD cord-014516-r59usk02 1360 4 - - SYM cord-014516-r59usk02 1360 5 2 2 CD cord-014516-r59usk02 1360 6 lM lm NN cord-014516-r59usk02 1360 7 ; ; : cord-014516-r59usk02 1360 8 piceatannol piceatannol NN cord-014516-r59usk02 1360 9 : : : cord-014516-r59usk02 1360 10 5 5 CD cord-014516-r59usk02 1360 11 - - SYM cord-014516-r59usk02 1360 12 50 50 CD cord-014516-r59usk02 1360 13 lM. lM. NNS cord-014516-r59usk02 1361 1 To to TO cord-014516-r59usk02 1361 2 further further RB cord-014516-r59usk02 1361 3 explore explore VB cord-014516-r59usk02 1361 4 the the DT cord-014516-r59usk02 1361 5 mechanism mechanism NN cord-014516-r59usk02 1361 6 of of IN cord-014516-r59usk02 1361 7 drug drug NN cord-014516-r59usk02 1361 8 - - HYPH cord-014516-r59usk02 1361 9 induced induce VBN cord-014516-r59usk02 1361 10 inhibition inhibition NN cord-014516-r59usk02 1361 11 of of IN cord-014516-r59usk02 1361 12 proliferation proliferation NN cord-014516-r59usk02 1361 13 , , , cord-014516-r59usk02 1361 14 we -PRON- PRP cord-014516-r59usk02 1361 15 examined examine VBD cord-014516-r59usk02 1361 16 cell cell NN cord-014516-r59usk02 1361 17 cycle cycle NN cord-014516-r59usk02 1361 18 progression progression NN cord-014516-r59usk02 1361 19 and and CC cord-014516-r59usk02 1361 20 apoptosis apoptosis NN cord-014516-r59usk02 1361 21 in in IN cord-014516-r59usk02 1361 22 drug drug NN cord-014516-r59usk02 1361 23 - - HYPH cord-014516-r59usk02 1361 24 exposed expose VBN cord-014516-r59usk02 1361 25 cells cell NNS cord-014516-r59usk02 1361 26 . . . cord-014516-r59usk02 1362 1 Whereas whereas IN cord-014516-r59usk02 1362 2 all all DT cord-014516-r59usk02 1362 3 4 4 CD cord-014516-r59usk02 1362 4 drugs drug NNS cord-014516-r59usk02 1362 5 tested test VBN cord-014516-r59usk02 1362 6 induced induce VBN cord-014516-r59usk02 1362 7 only only RB cord-014516-r59usk02 1362 8 moderate moderate JJ cord-014516-r59usk02 1362 9 cell cell NN cord-014516-r59usk02 1362 10 cycle cycle NN cord-014516-r59usk02 1362 11 arrests arrest NNS cord-014516-r59usk02 1362 12 in in IN cord-014516-r59usk02 1362 13 the the DT cord-014516-r59usk02 1362 14 G1 G1 NNP cord-014516-r59usk02 1362 15 phase phase NN cord-014516-r59usk02 1362 16 , , , cord-014516-r59usk02 1362 17 these these DT cord-014516-r59usk02 1362 18 drugs drug NNS cord-014516-r59usk02 1362 19 were be VBD cord-014516-r59usk02 1362 20 found find VBN cord-014516-r59usk02 1362 21 to to TO cord-014516-r59usk02 1362 22 induce induce VB cord-014516-r59usk02 1362 23 substantial substantial JJ cord-014516-r59usk02 1362 24 apoptosis apoptosis NN cord-014516-r59usk02 1362 25 in in IN cord-014516-r59usk02 1362 26 C2 C2 NNP cord-014516-r59usk02 1362 27 cells cell NNS cord-014516-r59usk02 1362 28 and and CC cord-014516-r59usk02 1362 29 NI-1 NI-1 NNP cord-014516-r59usk02 1362 30 cells cell NNS cord-014516-r59usk02 1362 31 as as IN cord-014516-r59usk02 1362 32 evidenced evidence VBN cord-014516-r59usk02 1362 33 by by IN cord-014516-r59usk02 1362 34 microscopy microscopy NNS cord-014516-r59usk02 1362 35 and and CC cord-014516-r59usk02 1362 36 Annexin Annexin NNP cord-014516-r59usk02 1362 37 - - HYPH cord-014516-r59usk02 1362 38 V V NNP cord-014516-r59usk02 1362 39 / / SYM cord-014516-r59usk02 1362 40 PI pi NN cord-014516-r59usk02 1362 41 staining staining NN cord-014516-r59usk02 1362 42 . . . cord-014516-r59usk02 1363 1 Together together RB cord-014516-r59usk02 1363 2 , , , cord-014516-r59usk02 1363 3 our -PRON- PRP$ cord-014516-r59usk02 1363 4 data datum NNS cord-014516-r59usk02 1363 5 show show VBP cord-014516-r59usk02 1363 6 that that IN cord-014516-r59usk02 1363 7 JAK2-and JAK2-and NNP cord-014516-r59usk02 1363 8 STAT5-targeting STAT5-targeting NNP cord-014516-r59usk02 1363 9 drugs drug NNS cord-014516-r59usk02 1363 10 exert exert VBP cord-014516-r59usk02 1363 11 anti anti JJ cord-014516-r59usk02 1363 12 - - JJ cord-014516-r59usk02 1363 13 proliferative proliferative JJ cord-014516-r59usk02 1363 14 and and CC cord-014516-r59usk02 1363 15 apoptosis apoptosis NN cord-014516-r59usk02 1363 16 - - HYPH cord-014516-r59usk02 1363 17 inducing induce VBG cord-014516-r59usk02 1363 18 effects effect NNS cord-014516-r59usk02 1363 19 in in IN cord-014516-r59usk02 1363 20 canine canine JJ cord-014516-r59usk02 1363 21 mastocytoma mastocytoma NN cord-014516-r59usk02 1363 22 cells cell NNS cord-014516-r59usk02 1363 23 suggesting suggest VBG cord-014516-r59usk02 1363 24 that that IN cord-014516-r59usk02 1363 25 this this DT cord-014516-r59usk02 1363 26 signaling signal VBG cord-014516-r59usk02 1363 27 pathway pathway NN cord-014516-r59usk02 1363 28 may may MD cord-014516-r59usk02 1363 29 be be VB cord-014516-r59usk02 1363 30 a a DT cord-014516-r59usk02 1363 31 promising promising JJ cord-014516-r59usk02 1363 32 new new JJ cord-014516-r59usk02 1363 33 therapeutic therapeutic JJ cord-014516-r59usk02 1363 34 target target NN cord-014516-r59usk02 1363 35 in in IN cord-014516-r59usk02 1363 36 canine canine JJ cord-014516-r59usk02 1363 37 mastocytomas mastocytomas NN cord-014516-r59usk02 1363 38 . . . cord-014516-r59usk02 1364 1 The the DT cord-014516-r59usk02 1364 2 clinical clinical JJ cord-014516-r59usk02 1364 3 relevance relevance NN cord-014516-r59usk02 1364 4 of of IN cord-014516-r59usk02 1364 5 this this DT cord-014516-r59usk02 1364 6 observation observation NN cord-014516-r59usk02 1364 7 remains remain VBZ cord-014516-r59usk02 1364 8 to to TO cord-014516-r59usk02 1364 9 be be VB cord-014516-r59usk02 1364 10 determined determine VBN cord-014516-r59usk02 1364 11 . . . cord-014516-r59usk02 1365 1 No no DT cord-014516-r59usk02 1365 2 conflicts conflict NNS cord-014516-r59usk02 1365 3 of of IN cord-014516-r59usk02 1365 4 interest interest NN cord-014516-r59usk02 1365 5 reported report VBN cord-014516-r59usk02 1365 6 . . . cord-014516-r59usk02 1366 1 Subcutaneous subcutaneous JJ cord-014516-r59usk02 1366 2 mast mast JJ cord-014516-r59usk02 1366 3 cell cell NN cord-014516-r59usk02 1366 4 tumours tumour NNS cord-014516-r59usk02 1366 5 ( ( -LRB- cord-014516-r59usk02 1366 6 SQMCT SQMCT NNP cord-014516-r59usk02 1366 7 ) ) -RRB- cord-014516-r59usk02 1366 8 in in IN cord-014516-r59usk02 1366 9 dogs dog NNS cord-014516-r59usk02 1366 10 are be VBP cord-014516-r59usk02 1366 11 relatively relatively RB cord-014516-r59usk02 1366 12 uncommon uncommon JJ cord-014516-r59usk02 1366 13 compared compare VBN cord-014516-r59usk02 1366 14 to to IN cord-014516-r59usk02 1366 15 their -PRON- PRP$ cord-014516-r59usk02 1366 16 cutaneous cutaneous JJ cord-014516-r59usk02 1366 17 counterparts counterpart NNS cord-014516-r59usk02 1366 18 . . . cord-014516-r59usk02 1367 1 The the DT cord-014516-r59usk02 1367 2 veterinary veterinary JJ cord-014516-r59usk02 1367 3 literature literature NN cord-014516-r59usk02 1367 4 describes describe VBZ cord-014516-r59usk02 1367 5 these these DT cord-014516-r59usk02 1367 6 tumours tumour NNS cord-014516-r59usk02 1367 7 as as IN cord-014516-r59usk02 1367 8 a a DT cord-014516-r59usk02 1367 9 specific specific JJ cord-014516-r59usk02 1367 10 pathological pathological JJ cord-014516-r59usk02 1367 11 entity entity NN cord-014516-r59usk02 1367 12 with with IN cord-014516-r59usk02 1367 13 , , , cord-014516-r59usk02 1367 14 in in IN cord-014516-r59usk02 1367 15 general general JJ cord-014516-r59usk02 1367 16 , , , cord-014516-r59usk02 1367 17 a a DT cord-014516-r59usk02 1367 18 low low JJ cord-014516-r59usk02 1367 19 probability probability NN cord-014516-r59usk02 1367 20 of of IN cord-014516-r59usk02 1367 21 aggressive aggressive JJ cord-014516-r59usk02 1367 22 progression progression NN cord-014516-r59usk02 1367 23 . . . cord-014516-r59usk02 1368 1 Surgery surgery NN cord-014516-r59usk02 1368 2 is be VBZ cord-014516-r59usk02 1368 3 considered consider VBN cord-014516-r59usk02 1368 4 the the DT cord-014516-r59usk02 1368 5 main main JJ cord-014516-r59usk02 1368 6 treatment treatment NN cord-014516-r59usk02 1368 7 modality modality NN cord-014516-r59usk02 1368 8 , , , cord-014516-r59usk02 1368 9 while while IN cord-014516-r59usk02 1368 10 medical medical JJ cord-014516-r59usk02 1368 11 treatment treatment NN cord-014516-r59usk02 1368 12 has have VBZ cord-014516-r59usk02 1368 13 not not RB cord-014516-r59usk02 1368 14 been be VBN cord-014516-r59usk02 1368 15 described describe VBN cord-014516-r59usk02 1368 16 . . . cord-014516-r59usk02 1369 1 The the DT cord-014516-r59usk02 1369 2 purpose purpose NN cord-014516-r59usk02 1369 3 of of IN cord-014516-r59usk02 1369 4 this this DT cord-014516-r59usk02 1369 5 study study NN cord-014516-r59usk02 1369 6 was be VBD cord-014516-r59usk02 1369 7 to to TO cord-014516-r59usk02 1369 8 determine determine VB cord-014516-r59usk02 1369 9 Progression Progression NNP cord-014516-r59usk02 1369 10 Free Free NNP cord-014516-r59usk02 1369 11 Survival Survival NNP cord-014516-r59usk02 1369 12 ( ( -LRB- cord-014516-r59usk02 1369 13 PFS PFS NNP cord-014516-r59usk02 1369 14 ) ) -RRB- cord-014516-r59usk02 1369 15 for for IN cord-014516-r59usk02 1369 16 a a DT cord-014516-r59usk02 1369 17 chemo chemo NN cord-014516-r59usk02 1369 18 na€ na€ NNP cord-014516-r59usk02 1369 19 ıve ıve JJ cord-014516-r59usk02 1369 20 cohort cohort NN cord-014516-r59usk02 1369 21 of of IN cord-014516-r59usk02 1369 22 dogs dog NNS cord-014516-r59usk02 1369 23 presented present VBN cord-014516-r59usk02 1369 24 with with IN cord-014516-r59usk02 1369 25 non non JJ cord-014516-r59usk02 1369 26 - - JJ cord-014516-r59usk02 1369 27 resectable resectable JJ cord-014516-r59usk02 1369 28 and/ and/ CD cord-014516-r59usk02 1369 29 or or CC cord-014516-r59usk02 1369 30 metastasized metastasize VBN cord-014516-r59usk02 1369 31 SQMCT SQMCT NNP cord-014516-r59usk02 1369 32 , , , cord-014516-r59usk02 1369 33 which which WDT cord-014516-r59usk02 1369 34 all all DT cord-014516-r59usk02 1369 35 underwent undergo VBD cord-014516-r59usk02 1369 36 masitinib masitinib NN cord-014516-r59usk02 1369 37 - - HYPH cord-014516-r59usk02 1369 38 based base VBN cord-014516-r59usk02 1369 39 therapy therapy NN cord-014516-r59usk02 1369 40 . . . cord-014516-r59usk02 1370 1 Data datum NNS cord-014516-r59usk02 1370 2 were be VBD cord-014516-r59usk02 1370 3 collected collect VBN cord-014516-r59usk02 1370 4 for for IN cord-014516-r59usk02 1370 5 patients patient NNS cord-014516-r59usk02 1370 6 with with IN cord-014516-r59usk02 1370 7 SQMCT SQMCT NNS cord-014516-r59usk02 1370 8 presented present VBN cord-014516-r59usk02 1370 9 to to IN cord-014516-r59usk02 1370 10 participating participate VBG cord-014516-r59usk02 1370 11 centres centre NNS cord-014516-r59usk02 1370 12 in in IN cord-014516-r59usk02 1370 13 the the DT cord-014516-r59usk02 1370 14 Netherlands Netherlands NNP cord-014516-r59usk02 1370 15 and and CC cord-014516-r59usk02 1370 16 the the DT cord-014516-r59usk02 1370 17 UK UK NNP cord-014516-r59usk02 1370 18 from from IN cord-014516-r59usk02 1370 19 01/12/ 01/12/ CD cord-014516-r59usk02 1370 20 2008 2008 CD cord-014516-r59usk02 1370 21 to to IN cord-014516-r59usk02 1370 22 01/01/2014 01/01/2014 CD cord-014516-r59usk02 1370 23 , , , cord-014516-r59usk02 1370 24 which which WDT cord-014516-r59usk02 1370 25 received receive VBD cord-014516-r59usk02 1370 26 masitinib masitinib NN cord-014516-r59usk02 1370 27 - - HYPH cord-014516-r59usk02 1370 28 based base VBN cord-014516-r59usk02 1370 29 therapy therapy NN cord-014516-r59usk02 1370 30 . . . cord-014516-r59usk02 1371 1 Treatment treatment NN cord-014516-r59usk02 1371 2 protocols protocol NNS cord-014516-r59usk02 1371 3 employed employ VBN cord-014516-r59usk02 1371 4 , , , cord-014516-r59usk02 1371 5 included include VBD cord-014516-r59usk02 1371 6 masitinib masitinib NN cord-014516-r59usk02 1371 7 alone alone JJ cord-014516-r59usk02 1371 8 ( ( -LRB- cord-014516-r59usk02 1371 9 M M NNP cord-014516-r59usk02 1371 10 ) ) -RRB- cord-014516-r59usk02 1371 11 , , , cord-014516-r59usk02 1371 12 masitinib masitinib NNP cord-014516-r59usk02 1371 13 and and CC cord-014516-r59usk02 1371 14 prednisolone prednisolone NN cord-014516-r59usk02 1371 15 ( ( -LRB- cord-014516-r59usk02 1371 16 MP MP NNP cord-014516-r59usk02 1371 17 ) ) -RRB- cord-014516-r59usk02 1371 18 , , , cord-014516-r59usk02 1371 19 masitinib masitinib NNP cord-014516-r59usk02 1371 20 plus plus CC cord-014516-r59usk02 1371 21 vinblastine vinblastine NNP cord-014516-r59usk02 1371 22 and/ and/ NNP cord-014516-r59usk02 1371 23 or or CC cord-014516-r59usk02 1371 24 lomustine lomustine NNP cord-014516-r59usk02 1371 25 and and CC cord-014516-r59usk02 1371 26 prednisolone prednisolone NNP cord-014516-r59usk02 1371 27 ( ( -LRB- cord-014516-r59usk02 1371 28 MPC MPC NNP cord-014516-r59usk02 1371 29 ) ) -RRB- cord-014516-r59usk02 1371 30 . . . cord-014516-r59usk02 1372 1 Response response NN cord-014516-r59usk02 1372 2 to to IN cord-014516-r59usk02 1372 3 therapy therapy NN cord-014516-r59usk02 1372 4 was be VBD cord-014516-r59usk02 1372 5 measured measure VBN cord-014516-r59usk02 1372 6 conforming conform VBG cord-014516-r59usk02 1372 7 to to IN cord-014516-r59usk02 1372 8 RECIST RECIST NNP cord-014516-r59usk02 1372 9 1.1 1.1 CD cord-014516-r59usk02 1372 10 . . . cord-014516-r59usk02 1373 1 Adverse adverse JJ cord-014516-r59usk02 1373 2 events event NNS cord-014516-r59usk02 1373 3 were be VBD cord-014516-r59usk02 1373 4 graded grade VBN cord-014516-r59usk02 1373 5 using use VBG cord-014516-r59usk02 1373 6 VCOG VCOG NNP cord-014516-r59usk02 1373 7 - - HYPH cord-014516-r59usk02 1373 8 CTCAE CTCAE NNP cord-014516-r59usk02 1373 9 1.1 1.1 CD cord-014516-r59usk02 1373 10 . . . cord-014516-r59usk02 1374 1 Patients patient NNS cord-014516-r59usk02 1374 2 were be VBD cord-014516-r59usk02 1374 3 grouped group VBN cord-014516-r59usk02 1374 4 according accord VBG cord-014516-r59usk02 1374 5 to to IN cord-014516-r59usk02 1374 6 presence presence NN cord-014516-r59usk02 1374 7 or or CC cord-014516-r59usk02 1374 8 absence absence NN cord-014516-r59usk02 1374 9 of of IN cord-014516-r59usk02 1374 10 metastasis metastasis NN cord-014516-r59usk02 1374 11 , , , cord-014516-r59usk02 1374 12 treatment treatment NN cord-014516-r59usk02 1374 13 protocol protocol NN cord-014516-r59usk02 1374 14 used use VBN cord-014516-r59usk02 1374 15 , , , cord-014516-r59usk02 1374 16 previous previous JJ cord-014516-r59usk02 1374 17 surgery surgery NN cord-014516-r59usk02 1374 18 , , , cord-014516-r59usk02 1374 19 and and CC cord-014516-r59usk02 1374 20 remission remission NN cord-014516-r59usk02 1374 21 status status NN cord-014516-r59usk02 1374 22 achieved achieve VBN cord-014516-r59usk02 1374 23 ; ; : cord-014516-r59usk02 1374 24 simple simple JJ cord-014516-r59usk02 1374 25 comparisons comparison NNS cord-014516-r59usk02 1374 26 were be VBD cord-014516-r59usk02 1374 27 made make VBN cord-014516-r59usk02 1374 28 to to TO cord-014516-r59usk02 1374 29 evaluate evaluate VB cord-014516-r59usk02 1374 30 possible possible JJ cord-014516-r59usk02 1374 31 significance significance NN cord-014516-r59usk02 1374 32 . . . cord-014516-r59usk02 1375 1 Twenty twenty CD cord-014516-r59usk02 1375 2 - - HYPH cord-014516-r59usk02 1375 3 five five CD cord-014516-r59usk02 1375 4 cases case NNS cord-014516-r59usk02 1375 5 were be VBD cord-014516-r59usk02 1375 6 identified identify VBN cord-014516-r59usk02 1375 7 . . . cord-014516-r59usk02 1376 1 18/25 18/25 CD cord-014516-r59usk02 1376 2 were be VBD cord-014516-r59usk02 1376 3 female female JJ cord-014516-r59usk02 1376 4 . . . cord-014516-r59usk02 1377 1 Median median JJ cord-014516-r59usk02 1377 2 age age NN cord-014516-r59usk02 1377 3 of of IN cord-014516-r59usk02 1377 4 occurrence occurrence NN cord-014516-r59usk02 1377 5 was be VBD cord-014516-r59usk02 1377 6 9 9 CD cord-014516-r59usk02 1377 7 years year NNS cord-014516-r59usk02 1377 8 ( ( -LRB- cord-014516-r59usk02 1377 9 2 2 CD cord-014516-r59usk02 1377 10 - - SYM cord-014516-r59usk02 1377 11 17 17 CD cord-014516-r59usk02 1377 12 ) ) -RRB- cord-014516-r59usk02 1377 13 . . . cord-014516-r59usk02 1378 1 Diagnosis diagnosis NN cord-014516-r59usk02 1378 2 was be VBD cord-014516-r59usk02 1378 3 made make VBN cord-014516-r59usk02 1378 4 by by IN cord-014516-r59usk02 1378 5 histology histology NN cord-014516-r59usk02 1378 6 in in IN cord-014516-r59usk02 1378 7 11/25 11/25 CD cord-014516-r59usk02 1378 8 ; ; : cord-014516-r59usk02 1378 9 proliferation proliferation NN cord-014516-r59usk02 1378 10 indices index NNS cord-014516-r59usk02 1378 11 were be VBD cord-014516-r59usk02 1378 12 defined define VBN cord-014516-r59usk02 1378 13 in in IN cord-014516-r59usk02 1378 14 only only RB cord-014516-r59usk02 1378 15 4 4 CD cord-014516-r59usk02 1378 16 dogs dog NNS cord-014516-r59usk02 1378 17 . . . cord-014516-r59usk02 1379 1 Fourteen fourteen CD cord-014516-r59usk02 1379 2 cases case NNS cord-014516-r59usk02 1379 3 exhibited exhibit VBD cord-014516-r59usk02 1379 4 metastasis metastasis NN cord-014516-r59usk02 1379 5 at at IN cord-014516-r59usk02 1379 6 initiation initiation NN cord-014516-r59usk02 1379 7 of of IN cord-014516-r59usk02 1379 8 therapy therapy NN cord-014516-r59usk02 1379 9 . . . cord-014516-r59usk02 1380 1 PFS PFS NNP cord-014516-r59usk02 1380 2 for for IN cord-014516-r59usk02 1380 3 all all DT cord-014516-r59usk02 1380 4 cases case NNS cord-014516-r59usk02 1380 5 ranged range VBD cord-014516-r59usk02 1380 6 from from IN cord-014516-r59usk02 1380 7 8 8 CD cord-014516-r59usk02 1380 8 - - SYM cord-014516-r59usk02 1380 9 1275 1275 CD cord-014516-r59usk02 1380 10 days day NNS cord-014516-r59usk02 1380 11 . . . cord-014516-r59usk02 1381 1 Median median JJ cord-014516-r59usk02 1381 2 / / SYM cord-014516-r59usk02 1381 3 mean mean VB cord-014516-r59usk02 1381 4 PFS PFS NNP cord-014516-r59usk02 1381 5 ( ( -LRB- cord-014516-r59usk02 1381 6 days day NNS cord-014516-r59usk02 1381 7 ) ) -RRB- cord-014516-r59usk02 1382 1 according accord VBG cord-014516-r59usk02 1382 2 to to IN cord-014516-r59usk02 1382 3 treatment treatment NN cord-014516-r59usk02 1382 4 was be VBD cord-014516-r59usk02 1382 5 M:141/317d m:141/317d JJ cord-014516-r59usk02 1382 6 ( ( -LRB- cord-014516-r59usk02 1382 7 n n NN cord-014516-r59usk02 1382 8 = = SYM cord-014516-r59usk02 1382 9 15 15 CD cord-014516-r59usk02 1382 10 ) ) -RRB- cord-014516-r59usk02 1382 11 , , . cord-014516-r59usk02 1383 1 MP:142/389d MP:142/389d NNP cord-014516-r59usk02 1384 1 ( ( -LRB- cord-014516-r59usk02 1384 2 n n NN cord-014516-r59usk02 1384 3 = = SYM cord-014516-r59usk02 1384 4 7 7 CD cord-014516-r59usk02 1384 5 ) ) -RRB- cord-014516-r59usk02 1384 6 , , , cord-014516-r59usk02 1384 7 MPC:49/57d MPC:49/57d NNP cord-014516-r59usk02 1384 8 ( ( -LRB- cord-014516-r59usk02 1384 9 n n NN cord-014516-r59usk02 1384 10 = = SYM cord-014516-r59usk02 1384 11 3 3 CD cord-014516-r59usk02 1384 12 ) ) -RRB- cord-014516-r59usk02 1384 13 . . . cord-014516-r59usk02 1385 1 Median median JJ cord-014516-r59usk02 1386 1 /mean /mean NNP cord-014516-r59usk02 1386 2 PFS PFS NNP cord-014516-r59usk02 1387 1 according accord VBG cord-014516-r59usk02 1387 2 to to IN cord-014516-r59usk02 1387 3 metastasis metastasis NN cord-014516-r59usk02 1387 4 status status NN cord-014516-r59usk02 1387 5 was be VBD cord-014516-r59usk02 1388 1 M0:141/324d M0:141/324d NNP cord-014516-r59usk02 1388 2 ( ( -LRB- cord-014516-r59usk02 1388 3 n n NN cord-014516-r59usk02 1388 4 = = SYM cord-014516-r59usk02 1388 5 11 11 CD cord-014516-r59usk02 1388 6 ) ) -RRB- cord-014516-r59usk02 1388 7 and and CC cord-014516-r59usk02 1388 8 M1:103/291d M1:103/291d NNP cord-014516-r59usk02 1388 9 ( ( -LRB- cord-014516-r59usk02 1388 10 n n NN cord-014516-r59usk02 1388 11 = = SYM cord-014516-r59usk02 1388 12 14 14 CD cord-014516-r59usk02 1388 13 ) ) -RRB- cord-014516-r59usk02 1388 14 . . . cord-014516-r59usk02 1389 1 Dogs dog NNS cord-014516-r59usk02 1389 2 who who WP cord-014516-r59usk02 1389 3 underwent undergo VBD cord-014516-r59usk02 1389 4 previous previous JJ cord-014516-r59usk02 1389 5 surgery surgery NN cord-014516-r59usk02 1390 1 ( ( -LRB- cord-014516-r59usk02 1390 2 n n NN cord-014516-r59usk02 1390 3 = = SYM cord-014516-r59usk02 1390 4 10 10 CD cord-014516-r59usk02 1390 5 ) ) -RRB- cord-014516-r59usk02 1390 6 had have VBD cord-014516-r59usk02 1390 7 a a DT cord-014516-r59usk02 1390 8 median median NN cord-014516-r59usk02 1390 9 / / , cord-014516-r59usk02 1390 10 mean mean VB cord-014516-r59usk02 1390 11 PFS PFS NNP cord-014516-r59usk02 1390 12 of of IN cord-014516-r59usk02 1390 13 108/344d 108/344d CD cord-014516-r59usk02 1390 14 compared compare VBN cord-014516-r59usk02 1390 15 to to IN cord-014516-r59usk02 1390 16 those those DT cord-014516-r59usk02 1390 17 who who WP cord-014516-r59usk02 1390 18 had have VBD cord-014516-r59usk02 1390 19 no no DT cord-014516-r59usk02 1390 20 surgery surgery NN cord-014516-r59usk02 1390 21 119/280d 119/280d CD cord-014516-r59usk02 1390 22 . . . cord-014516-r59usk02 1391 1 Looking look VBG cord-014516-r59usk02 1391 2 at at IN cord-014516-r59usk02 1391 3 remission remission NN cord-014516-r59usk02 1391 4 status status NN cord-014516-r59usk02 1391 5 , , , cord-014516-r59usk02 1391 6 median median JJ cord-014516-r59usk02 1391 7 PFS PFS NNP cord-014516-r59usk02 1391 8 of of IN cord-014516-r59usk02 1391 9 patients patient NNS cord-014516-r59usk02 1391 10 who who WP cord-014516-r59usk02 1391 11 achieved achieve VBD cord-014516-r59usk02 1391 12 a a DT cord-014516-r59usk02 1391 13 complete complete JJ cord-014516-r59usk02 1391 14 remission remission NN cord-014516-r59usk02 1391 15 was be VBD cord-014516-r59usk02 1391 16 not not RB cord-014516-r59usk02 1391 17 reached reach VBN cord-014516-r59usk02 1391 18 , , , cord-014516-r59usk02 1391 19 with with IN cord-014516-r59usk02 1391 20 a a DT cord-014516-r59usk02 1391 21 mean mean JJ cord-014516-r59usk02 1391 22 PFS PFS NNP cord-014516-r59usk02 1391 23 of of IN cord-014516-r59usk02 1391 24 617d 617d NNP cord-014516-r59usk02 1391 25 ( ( -LRB- cord-014516-r59usk02 1391 26 n n NN cord-014516-r59usk02 1391 27 = = SYM cord-014516-r59usk02 1391 28 9 9 CD cord-014516-r59usk02 1391 29 ) ) -RRB- cord-014516-r59usk02 1391 30 . . . cord-014516-r59usk02 1392 1 Median median JJ cord-014516-r59usk02 1393 1 /mean /mean NNP cord-014516-r59usk02 1393 2 PFS PFS NNP cord-014516-r59usk02 1393 3 of of IN cord-014516-r59usk02 1393 4 patients patient NNS cord-014516-r59usk02 1393 5 with with IN cord-014516-r59usk02 1393 6 partial partial JJ cord-014516-r59usk02 1393 7 remission remission NN cord-014516-r59usk02 1393 8 was be VBD cord-014516-r59usk02 1393 9 86/176d 86/176d CD cord-014516-r59usk02 1393 10 ( ( -LRB- cord-014516-r59usk02 1393 11 n n NN cord-014516-r59usk02 1393 12 = = SYM cord-014516-r59usk02 1393 13 11 11 CD cord-014516-r59usk02 1393 14 ) ) -RRB- cord-014516-r59usk02 1393 15 , , , cord-014516-r59usk02 1393 16 stable stable JJ cord-014516-r59usk02 1393 17 disease disease NN cord-014516-r59usk02 1393 18 49/57d 49/57d CD cord-014516-r59usk02 1394 1 ( ( -LRB- cord-014516-r59usk02 1394 2 n n NN cord-014516-r59usk02 1394 3 = = SYM cord-014516-r59usk02 1394 4 2 2 CD cord-014516-r59usk02 1394 5 ) ) -RRB- cord-014516-r59usk02 1394 6 , , , cord-014516-r59usk02 1394 7 and and CC cord-014516-r59usk02 1394 8 progressive progressive JJ cord-014516-r59usk02 1394 9 disease disease NN cord-014516-r59usk02 1394 10 12/17d 12/17d CD cord-014516-r59usk02 1395 1 ( ( -LRB- cord-014516-r59usk02 1395 2 n n NN cord-014516-r59usk02 1395 3 = = SYM cord-014516-r59usk02 1395 4 3 3 CD cord-014516-r59usk02 1395 5 ) ) -RRB- cord-014516-r59usk02 1395 6 . . . cord-014516-r59usk02 1396 1 19/25 19/25 CD cord-014516-r59usk02 1396 2 cases case NNS cord-014516-r59usk02 1396 3 experienced experience VBD cord-014516-r59usk02 1396 4 suspected suspect VBN cord-014516-r59usk02 1396 5 adverse adverse JJ cord-014516-r59usk02 1396 6 events event NNS cord-014516-r59usk02 1396 7 . . . cord-014516-r59usk02 1397 1 Three three CD cord-014516-r59usk02 1397 2 dogs dog NNS cord-014516-r59usk02 1397 3 , , , cord-014516-r59usk02 1397 4 two two CD cord-014516-r59usk02 1397 5 of of IN cord-014516-r59usk02 1397 6 which which WDT cord-014516-r59usk02 1397 7 ultimately ultimately RB cord-014516-r59usk02 1397 8 died die VBD cord-014516-r59usk02 1397 9 , , , cord-014516-r59usk02 1397 10 had have VBD cord-014516-r59usk02 1397 11 seven seven CD cord-014516-r59usk02 1397 12 grade grade NN cord-014516-r59usk02 1397 13 3 3 CD cord-014516-r59usk02 1397 14 - - SYM cord-014516-r59usk02 1397 15 5 5 CD cord-014516-r59usk02 1397 16 adverse adverse JJ cord-014516-r59usk02 1397 17 events event NNS cord-014516-r59usk02 1397 18 ( ( -LRB- cord-014516-r59usk02 1397 19 anaemia anaemia NN cord-014516-r59usk02 1397 20 ( ( -LRB- cord-014516-r59usk02 1397 21 n n NN cord-014516-r59usk02 1397 22 = = SYM cord-014516-r59usk02 1397 23 3 3 CD cord-014516-r59usk02 1397 24 ) ) -RRB- cord-014516-r59usk02 1397 25 , , , cord-014516-r59usk02 1397 26 hepatotoxicity hepatotoxicity NN cord-014516-r59usk02 1397 27 ( ( -LRB- cord-014516-r59usk02 1397 28 n n NN cord-014516-r59usk02 1397 29 = = SYM cord-014516-r59usk02 1397 30 3 3 CD cord-014516-r59usk02 1397 31 ) ) -RRB- cord-014516-r59usk02 1397 32 , , , cord-014516-r59usk02 1397 33 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 1397 34 toxicity toxicity NN cord-014516-r59usk02 1397 35 ( ( -LRB- cord-014516-r59usk02 1397 36 n n NN cord-014516-r59usk02 1397 37 = = SYM cord-014516-r59usk02 1397 38 1 1 CD cord-014516-r59usk02 1397 39 ) ) -RRB- cord-014516-r59usk02 1397 40 ) ) -RRB- cord-014516-r59usk02 1397 41 . . . cord-014516-r59usk02 1398 1 Masitinib Masitinib NNP cord-014516-r59usk02 1398 2 - - HYPH cord-014516-r59usk02 1398 3 based base VBN cord-014516-r59usk02 1398 4 treatment treatment NN cord-014516-r59usk02 1398 5 is be VBZ cord-014516-r59usk02 1398 6 effective effective JJ cord-014516-r59usk02 1398 7 in in IN cord-014516-r59usk02 1398 8 the the DT cord-014516-r59usk02 1398 9 management management NN cord-014516-r59usk02 1398 10 of of IN cord-014516-r59usk02 1398 11 SQMCT SQMCT NNP cord-014516-r59usk02 1398 12 perceived perceive VBN cord-014516-r59usk02 1398 13 to to TO cord-014516-r59usk02 1398 14 be be VB cord-014516-r59usk02 1398 15 aggressive aggressive JJ cord-014516-r59usk02 1398 16 . . . cord-014516-r59usk02 1399 1 Patients patient NNS cord-014516-r59usk02 1399 2 do do VBP cord-014516-r59usk02 1399 3 not not RB cord-014516-r59usk02 1399 4 appear appear VB cord-014516-r59usk02 1399 5 to to TO cord-014516-r59usk02 1399 6 benefit benefit VB cord-014516-r59usk02 1399 7 from from IN cord-014516-r59usk02 1399 8 prior prior JJ cord-014516-r59usk02 1399 9 surgery surgery NN cord-014516-r59usk02 1399 10 . . . cord-014516-r59usk02 1400 1 Metastatic metastatic JJ cord-014516-r59usk02 1400 2 status status NN cord-014516-r59usk02 1400 3 did do VBD cord-014516-r59usk02 1400 4 not not RB cord-014516-r59usk02 1400 5 influence influence VB cord-014516-r59usk02 1400 6 outcome outcome NN cord-014516-r59usk02 1400 7 . . . cord-014516-r59usk02 1401 1 Adding add VBG cord-014516-r59usk02 1401 2 chemotherapy chemotherapy NN cord-014516-r59usk02 1401 3 negatively negatively RB cord-014516-r59usk02 1401 4 influenced influence VBD cord-014516-r59usk02 1401 5 PFS PFS NNP cord-014516-r59usk02 1401 6 . . . cord-014516-r59usk02 1402 1 Complete complete JJ cord-014516-r59usk02 1402 2 remission remission NN cord-014516-r59usk02 1402 3 is be VBZ cord-014516-r59usk02 1402 4 a a DT cord-014516-r59usk02 1402 5 very very RB cord-014516-r59usk02 1402 6 favourable favourable JJ cord-014516-r59usk02 1402 7 prognostic prognostic JJ cord-014516-r59usk02 1402 8 development development NN cord-014516-r59usk02 1402 9 . . . cord-014516-r59usk02 1403 1 The the DT cord-014516-r59usk02 1403 2 authors author NNS cord-014516-r59usk02 1403 3 have have VBP cord-014516-r59usk02 1403 4 received receive VBN cord-014516-r59usk02 1403 5 financial financial JJ cord-014516-r59usk02 1403 6 support support NN cord-014516-r59usk02 1403 7 from from IN cord-014516-r59usk02 1403 8 AB AB NNP cord-014516-r59usk02 1403 9 Science Science NNP cord-014516-r59usk02 1403 10 to to TO cord-014516-r59usk02 1403 11 help help VB cord-014516-r59usk02 1403 12 with with IN cord-014516-r59usk02 1403 13 the the DT cord-014516-r59usk02 1403 14 costs cost NNS cord-014516-r59usk02 1403 15 of of IN cord-014516-r59usk02 1403 16 statistical statistical JJ cord-014516-r59usk02 1403 17 analyses analysis NNS cord-014516-r59usk02 1403 18 in in IN cord-014516-r59usk02 1403 19 an an DT cord-014516-r59usk02 1403 20 unrelated unrelated JJ cord-014516-r59usk02 1403 21 project project NN cord-014516-r59usk02 1403 22 Advances advance NNS cord-014516-r59usk02 1403 23 in in IN cord-014516-r59usk02 1403 24 distinction distinction NN cord-014516-r59usk02 1403 25 between between IN cord-014516-r59usk02 1403 26 morphological morphological JJ cord-014516-r59usk02 1403 27 subtypes subtype NNS cord-014516-r59usk02 1403 28 of of IN cord-014516-r59usk02 1403 29 canine canine JJ cord-014516-r59usk02 1403 30 non non JJ cord-014516-r59usk02 1403 31 - - JJ cord-014516-r59usk02 1403 32 Hodgkin Hodgkin NNP cord-014516-r59usk02 1403 33 's 's POS cord-014516-r59usk02 1403 34 lymphomas lymphoma NNS cord-014516-r59usk02 1403 35 ( ( -LRB- cord-014516-r59usk02 1403 36 NHL NHL NNP cord-014516-r59usk02 1403 37 ) ) -RRB- cord-014516-r59usk02 1403 38 have have VBP cord-014516-r59usk02 1403 39 provided provide VBN cord-014516-r59usk02 1403 40 a a DT cord-014516-r59usk02 1403 41 better well JJR cord-014516-r59usk02 1403 42 understanding understanding NN cord-014516-r59usk02 1403 43 of of IN cord-014516-r59usk02 1403 44 this this DT cord-014516-r59usk02 1403 45 cancer cancer NN cord-014516-r59usk02 1403 46 in in IN cord-014516-r59usk02 1403 47 dogs dog NNS cord-014516-r59usk02 1403 48 . . . cord-014516-r59usk02 1404 1 Diffuse diffuse VB cord-014516-r59usk02 1404 2 large large JJ cord-014516-r59usk02 1404 3 B b NN cord-014516-r59usk02 1404 4 - - HYPH cord-014516-r59usk02 1404 5 cell cell NN cord-014516-r59usk02 1404 6 lymphomas lymphoma NNS cord-014516-r59usk02 1404 7 ( ( -LRB- cord-014516-r59usk02 1404 8 DLBCL DLBCL NNP cord-014516-r59usk02 1404 9 ) ) -RRB- cord-014516-r59usk02 1404 10 are be VBP cord-014516-r59usk02 1404 11 the the DT cord-014516-r59usk02 1404 12 most most RBS cord-014516-r59usk02 1404 13 frequent frequent JJ cord-014516-r59usk02 1404 14 form form NN cord-014516-r59usk02 1404 15 of of IN cord-014516-r59usk02 1404 16 NHL NHL NNP cord-014516-r59usk02 1404 17 in in IN cord-014516-r59usk02 1404 18 dogs dog NNS cord-014516-r59usk02 1404 19 including include VBG cord-014516-r59usk02 1404 20 some some DT cord-014516-r59usk02 1404 21 distinguished distinguished JJ cord-014516-r59usk02 1404 22 morphological morphological JJ cord-014516-r59usk02 1404 23 subtypes subtype NNS cord-014516-r59usk02 1404 24 ( ( -LRB- cord-014516-r59usk02 1404 25 mainly mainly RB cord-014516-r59usk02 1404 26 centroblastic centroblastic JJ cord-014516-r59usk02 1404 27 polymorphic polymorphic JJ cord-014516-r59usk02 1404 28 and and CC cord-014516-r59usk02 1404 29 immunoblastic immunoblastic JJ cord-014516-r59usk02 1404 30 ) ) -RRB- cord-014516-r59usk02 1404 31 according accord VBG cord-014516-r59usk02 1404 32 to to IN cord-014516-r59usk02 1404 33 the the DT cord-014516-r59usk02 1404 34 WHO WHO NNP cord-014516-r59usk02 1404 35 classification classification NN cord-014516-r59usk02 1404 36 . . . cord-014516-r59usk02 1405 1 Few few JJ cord-014516-r59usk02 1405 2 clinical clinical JJ cord-014516-r59usk02 1405 3 studies study NNS cord-014516-r59usk02 1405 4 reported report VBD cord-014516-r59usk02 1405 5 DLBCL dlbcl IN cord-014516-r59usk02 1405 6 clinical clinical JJ cord-014516-r59usk02 1405 7 outcomes outcome NNS cord-014516-r59usk02 1405 8 under under IN cord-014516-r59usk02 1405 9 treatment treatment NN cord-014516-r59usk02 1405 10 while while IN cord-014516-r59usk02 1405 11 survival survival NN cord-014516-r59usk02 1405 12 times time NNS cord-014516-r59usk02 1405 13 of of IN cord-014516-r59usk02 1405 14 the the DT cord-014516-r59usk02 1405 15 centroblastic centroblastic JJ cord-014516-r59usk02 1405 16 polymorphic polymorphic JJ cord-014516-r59usk02 1405 17 subgroup subgroup NN cord-014516-r59usk02 1405 18 were be VBD cord-014516-r59usk02 1405 19 reported report VBN cord-014516-r59usk02 1405 20 . . . cord-014516-r59usk02 1406 1 The the DT cord-014516-r59usk02 1406 2 aim aim NN cord-014516-r59usk02 1406 3 of of IN cord-014516-r59usk02 1406 4 this this DT cord-014516-r59usk02 1406 5 retrospective retrospective JJ cord-014516-r59usk02 1406 6 study study NN cord-014516-r59usk02 1406 7 was be VBD cord-014516-r59usk02 1406 8 to to TO cord-014516-r59usk02 1406 9 evaluate evaluate VB cord-014516-r59usk02 1406 10 the the DT cord-014516-r59usk02 1406 11 response response NN cord-014516-r59usk02 1406 12 of of IN cord-014516-r59usk02 1406 13 DLBCL DLBCL NNP cord-014516-r59usk02 1406 14 to to IN cord-014516-r59usk02 1406 15 a a DT cord-014516-r59usk02 1406 16 standardized standardized JJ cord-014516-r59usk02 1406 17 multi multi JJ cord-014516-r59usk02 1406 18 - - JJ cord-014516-r59usk02 1406 19 agent agent JJ cord-014516-r59usk02 1406 20 chemotherapy chemotherapy NN cord-014516-r59usk02 1406 21 protocol protocol NN cord-014516-r59usk02 1406 22 . . . cord-014516-r59usk02 1407 1 Medical medical JJ cord-014516-r59usk02 1407 2 records record NNS cord-014516-r59usk02 1407 3 from from IN cord-014516-r59usk02 1407 4 dogs dog NNS cord-014516-r59usk02 1407 5 with with IN cord-014516-r59usk02 1407 6 a a DT cord-014516-r59usk02 1407 7 diagnosis diagnosis NN cord-014516-r59usk02 1407 8 of of IN cord-014516-r59usk02 1407 9 DLBCL DLBCL NNP cord-014516-r59usk02 1407 10 between between IN cord-014516-r59usk02 1407 11 2003 2003 CD cord-014516-r59usk02 1407 12 and and CC cord-014516-r59usk02 1407 13 2013 2013 CD cord-014516-r59usk02 1407 14 were be VBD cord-014516-r59usk02 1407 15 retrospectively retrospectively RB cord-014516-r59usk02 1407 16 reviewed review VBN cord-014516-r59usk02 1407 17 . . . cord-014516-r59usk02 1408 1 Inclusion inclusion NN cord-014516-r59usk02 1408 2 criteria criterion NNS cord-014516-r59usk02 1408 3 were be VBD cord-014516-r59usk02 1408 4 the the DT cord-014516-r59usk02 1408 5 availability availability NN cord-014516-r59usk02 1408 6 of of IN cord-014516-r59usk02 1408 7 complete complete JJ cord-014516-r59usk02 1408 8 initial initial JJ cord-014516-r59usk02 1408 9 and and CC cord-014516-r59usk02 1408 10 follow follow NN cord-014516-r59usk02 1408 11 - - HYPH cord-014516-r59usk02 1408 12 up up RP cord-014516-r59usk02 1408 13 information information NN cord-014516-r59usk02 1408 14 and and CC cord-014516-r59usk02 1408 15 the the DT cord-014516-r59usk02 1408 16 application application NN cord-014516-r59usk02 1408 17 of of IN cord-014516-r59usk02 1408 18 a a DT cord-014516-r59usk02 1408 19 standardized standardized JJ cord-014516-r59usk02 1408 20 multi multi JJ cord-014516-r59usk02 1408 21 - - JJ cord-014516-r59usk02 1408 22 agent agent JJ cord-014516-r59usk02 1408 23 L l NN cord-014516-r59usk02 1408 24 - - HYPH cord-014516-r59usk02 1408 25 COP cop NN cord-014516-r59usk02 1408 26 chemotherapy chemotherapy NN cord-014516-r59usk02 1408 27 protocol protocol NN cord-014516-r59usk02 1408 28 as as IN cord-014516-r59usk02 1408 29 previously previously RB cord-014516-r59usk02 1408 30 described describe VBN cord-014516-r59usk02 1408 31 . . . cord-014516-r59usk02 1409 1 Dogs dog NNS cord-014516-r59usk02 1409 2 which which WDT cord-014516-r59usk02 1409 3 received receive VBD cord-014516-r59usk02 1409 4 corticosteroids corticosteroid NNS cord-014516-r59usk02 1409 5 before before IN cord-014516-r59usk02 1409 6 the the DT cord-014516-r59usk02 1409 7 initiation initiation NN cord-014516-r59usk02 1409 8 of of IN cord-014516-r59usk02 1409 9 treatment treatment NN cord-014516-r59usk02 1409 10 and and CC cord-014516-r59usk02 1409 11 dogs dog NNS cord-014516-r59usk02 1409 12 which which WDT cord-014516-r59usk02 1409 13 died die VBD cord-014516-r59usk02 1409 14 for for IN cord-014516-r59usk02 1409 15 other other JJ cord-014516-r59usk02 1409 16 reasons reason NNS cord-014516-r59usk02 1409 17 than than IN cord-014516-r59usk02 1409 18 their -PRON- PRP$ cord-014516-r59usk02 1409 19 related relate VBN cord-014516-r59usk02 1409 20 disease disease NN cord-014516-r59usk02 1409 21 before before IN cord-014516-r59usk02 1409 22 the the DT cord-014516-r59usk02 1409 23 end end NN cord-014516-r59usk02 1409 24 of of IN cord-014516-r59usk02 1409 25 the the DT cord-014516-r59usk02 1409 26 induction induction NN cord-014516-r59usk02 1409 27 period period NN cord-014516-r59usk02 1409 28 ( ( -LRB- cord-014516-r59usk02 1409 29 35 35 CD cord-014516-r59usk02 1409 30 d d NN cord-014516-r59usk02 1409 31 ) ) -RRB- cord-014516-r59usk02 1409 32 were be VBD cord-014516-r59usk02 1409 33 excluded exclude VBN cord-014516-r59usk02 1409 34 . . . cord-014516-r59usk02 1410 1 Response response NN cord-014516-r59usk02 1410 2 to to IN cord-014516-r59usk02 1410 3 chemotherapy chemotherapy NN cord-014516-r59usk02 1410 4 was be VBD cord-014516-r59usk02 1410 5 evaluated evaluate VBN cord-014516-r59usk02 1410 6 every every DT cord-014516-r59usk02 1410 7 week week NN cord-014516-r59usk02 1410 8 during during IN cord-014516-r59usk02 1410 9 the the DT cord-014516-r59usk02 1410 10 induction induction NN cord-014516-r59usk02 1410 11 of of IN cord-014516-r59usk02 1410 12 treatment treatment NN cord-014516-r59usk02 1410 13 , , , cord-014516-r59usk02 1410 14 then then RB cord-014516-r59usk02 1410 15 every every DT cord-014516-r59usk02 1410 16 3 3 CD cord-014516-r59usk02 1410 17 to to TO cord-014516-r59usk02 1410 18 5 5 CD cord-014516-r59usk02 1410 19 weeks week NNS cord-014516-r59usk02 1410 20 . . . cord-014516-r59usk02 1411 1 Statistical statistical JJ cord-014516-r59usk02 1411 2 analysis analysis NN cord-014516-r59usk02 1411 3 was be VBD cord-014516-r59usk02 1411 4 performed perform VBN cord-014516-r59usk02 1411 5 using use VBG cord-014516-r59usk02 1411 6 Kaplan Kaplan NNP cord-014516-r59usk02 1411 7 - - HYPH cord-014516-r59usk02 1411 8 Meier Meier NNP cord-014516-r59usk02 1411 9 analysis analysis NN cord-014516-r59usk02 1411 10 . . . cord-014516-r59usk02 1412 1 Thirty thirty CD cord-014516-r59usk02 1412 2 cases case NNS cord-014516-r59usk02 1412 3 of of IN cord-014516-r59usk02 1412 4 DLBCL DLBCL NNP cord-014516-r59usk02 1412 5 meeting meet VBG cord-014516-r59usk02 1412 6 all all DT cord-014516-r59usk02 1412 7 inclusion inclusion NN cord-014516-r59usk02 1412 8 criteria criterion NNS cord-014516-r59usk02 1412 9 were be VBD cord-014516-r59usk02 1412 10 included include VBN cord-014516-r59usk02 1412 11 from from IN cord-014516-r59usk02 1412 12 the the DT cord-014516-r59usk02 1412 13 initial initial JJ cord-014516-r59usk02 1412 14 population population NN cord-014516-r59usk02 1412 15 . . . cord-014516-r59usk02 1413 1 Seven seven CD cord-014516-r59usk02 1413 2 dogs dog NNS cord-014516-r59usk02 1413 3 were be VBD cord-014516-r59usk02 1413 4 in in IN cord-014516-r59usk02 1413 5 clinical clinical JJ cord-014516-r59usk02 1413 6 stage stage NN cord-014516-r59usk02 1413 7 III III NNP cord-014516-r59usk02 1413 8 according accord VBG cord-014516-r59usk02 1413 9 to to IN cord-014516-r59usk02 1413 10 the the DT cord-014516-r59usk02 1413 11 WHO WHO NNP cord-014516-r59usk02 1413 12 classification classification NN cord-014516-r59usk02 1413 13 , , , cord-014516-r59usk02 1413 14 19 19 CD cord-014516-r59usk02 1413 15 in in IN cord-014516-r59usk02 1413 16 stage stage NN cord-014516-r59usk02 1413 17 IV IV NNP cord-014516-r59usk02 1413 18 and and CC cord-014516-r59usk02 1413 19 4 4 CD cord-014516-r59usk02 1413 20 in in IN cord-014516-r59usk02 1413 21 stage stage NN cord-014516-r59usk02 1414 1 V. V. NNP cord-014516-r59usk02 1414 2 Nineteen nineteen CD cord-014516-r59usk02 1414 3 dogs dog NNS cord-014516-r59usk02 1414 4 were be VBD cord-014516-r59usk02 1414 5 in in IN cord-014516-r59usk02 1414 6 substage substage NN cord-014516-r59usk02 1414 7 a a NN cord-014516-r59usk02 1414 8 , , , cord-014516-r59usk02 1414 9 and and CC cord-014516-r59usk02 1414 10 11 11 CD cord-014516-r59usk02 1414 11 in in IN cord-014516-r59usk02 1414 12 substage substage NN cord-014516-r59usk02 1414 13 b. b. NNP cord-014516-r59usk02 1415 1 On on IN cord-014516-r59usk02 1415 2 26 26 CD cord-014516-r59usk02 1415 3 dogs dog NNS cord-014516-r59usk02 1415 4 which which WDT cord-014516-r59usk02 1415 5 have have VBP cord-014516-r59usk02 1415 6 an an DT cord-014516-r59usk02 1415 7 adequate adequate JJ cord-014516-r59usk02 1415 8 response response NN cord-014516-r59usk02 1415 9 evaluation evaluation NN cord-014516-r59usk02 1415 10 , , , cord-014516-r59usk02 1415 11 20 20 CD cord-014516-r59usk02 1415 12 dogs dog NNS cord-014516-r59usk02 1415 13 ( ( -LRB- cord-014516-r59usk02 1415 14 76.9 76.9 CD cord-014516-r59usk02 1415 15 % % NN cord-014516-r59usk02 1415 16 ) ) -RRB- cord-014516-r59usk02 1415 17 achieved achieve VBD cord-014516-r59usk02 1415 18 a a DT cord-014516-r59usk02 1415 19 complete complete JJ cord-014516-r59usk02 1415 20 remission remission NN cord-014516-r59usk02 1415 21 . . . cord-014516-r59usk02 1416 1 The the DT cord-014516-r59usk02 1416 2 median median NN cord-014516-r59usk02 1416 3 and and CC cord-014516-r59usk02 1416 4 mean mean JJ cord-014516-r59usk02 1416 5 duration duration NN cord-014516-r59usk02 1416 6 of of IN cord-014516-r59usk02 1416 7 first first JJ cord-014516-r59usk02 1416 8 remission remission NN cord-014516-r59usk02 1416 9 were be VBD cord-014516-r59usk02 1416 10 175d 175d NNP cord-014516-r59usk02 1416 11 and and CC cord-014516-r59usk02 1416 12 239d 239d NNS cord-014516-r59usk02 1416 13 , , , cord-014516-r59usk02 1416 14 respectively respectively RB cord-014516-r59usk02 1417 1 ( ( -LRB- cord-014516-r59usk02 1417 2 range range VBP cord-014516-r59usk02 1417 3 68 68 CD cord-014516-r59usk02 1417 4 - - SYM cord-014516-r59usk02 1417 5 725 725 CD cord-014516-r59usk02 1417 6 d d NN cord-014516-r59usk02 1417 7 ) ) -RRB- cord-014516-r59usk02 1417 8 . . . cord-014516-r59usk02 1418 1 The the DT cord-014516-r59usk02 1418 2 median median NN cord-014516-r59usk02 1418 3 and and CC cord-014516-r59usk02 1418 4 mean mean VB cord-014516-r59usk02 1418 5 durations duration NNS cord-014516-r59usk02 1418 6 of of IN cord-014516-r59usk02 1418 7 survival survival NN cord-014516-r59usk02 1418 8 time time NN cord-014516-r59usk02 1418 9 were be VBD cord-014516-r59usk02 1418 10 respectively respectively RB cord-014516-r59usk02 1418 11 311d 311d NNPS cord-014516-r59usk02 1418 12 and and CC cord-014516-r59usk02 1418 13 319d 319d NNPS cord-014516-r59usk02 1419 1 ( ( -LRB- cord-014516-r59usk02 1419 2 range range VBP cord-014516-r59usk02 1419 3 55 55 CD cord-014516-r59usk02 1419 4 - - SYM cord-014516-r59usk02 1419 5 818 818 CD cord-014516-r59usk02 1419 6 d d CD cord-014516-r59usk02 1419 7 ) ) -RRB- cord-014516-r59usk02 1419 8 . . . cord-014516-r59usk02 1420 1 One one CD cord-014516-r59usk02 1420 2 year year NN cord-014516-r59usk02 1420 3 and and CC cord-014516-r59usk02 1420 4 2-years 2-years CD cord-014516-r59usk02 1420 5 survival survival NN cord-014516-r59usk02 1420 6 rates rate NNS cord-014516-r59usk02 1420 7 were be VBD cord-014516-r59usk02 1420 8 32 32 CD cord-014516-r59usk02 1420 9 % % NN cord-014516-r59usk02 1420 10 and and CC cord-014516-r59usk02 1420 11 3 3 CD cord-014516-r59usk02 1420 12 % % NN cord-014516-r59usk02 1420 13 respectively respectively RB cord-014516-r59usk02 1420 14 . . . cord-014516-r59usk02 1421 1 According accord VBG cord-014516-r59usk02 1421 2 to to IN cord-014516-r59usk02 1421 3 the the DT cord-014516-r59usk02 1421 4 statistical statistical JJ cord-014516-r59usk02 1421 5 analysis analysis NN cord-014516-r59usk02 1421 6 , , , cord-014516-r59usk02 1421 7 neither neither CC cord-014516-r59usk02 1421 8 clinical clinical JJ cord-014516-r59usk02 1421 9 stage stage NN cord-014516-r59usk02 1421 10 ( ( -LRB- cord-014516-r59usk02 1421 11 p p NN cord-014516-r59usk02 1421 12 = = SYM cord-014516-r59usk02 1421 13 0.726 0.726 CD cord-014516-r59usk02 1421 14 ) ) -RRB- cord-014516-r59usk02 1421 15 nor nor CC cord-014516-r59usk02 1421 16 substage substage VBN cord-014516-r59usk02 1421 17 at at IN cord-014516-r59usk02 1421 18 presentation presentation NN cord-014516-r59usk02 1421 19 ( ( -LRB- cord-014516-r59usk02 1421 20 p p NN cord-014516-r59usk02 1421 21 = = SYM cord-014516-r59usk02 1421 22 0.83 0.83 CD cord-014516-r59usk02 1421 23 ) ) -RRB- cord-014516-r59usk02 1421 24 or or CC cord-014516-r59usk02 1421 25 morphological morphological JJ cord-014516-r59usk02 1421 26 subtype subtype NN cord-014516-r59usk02 1421 27 ( ( -LRB- cord-014516-r59usk02 1421 28 immunoblastic immunoblastic NNP cord-014516-r59usk02 1421 29 vs vs IN cord-014516-r59usk02 1421 30 centroblastic centroblastic NNP cord-014516-r59usk02 1421 31 polymorphic polymorphic JJ cord-014516-r59usk02 1421 32 , , , cord-014516-r59usk02 1421 33 p p NN cord-014516-r59usk02 1421 34 = = SYM cord-014516-r59usk02 1421 35 0.216 0.216 CD cord-014516-r59usk02 1421 36 ) ) -RRB- cord-014516-r59usk02 1421 37 were be VBD cord-014516-r59usk02 1421 38 considered consider VBN cord-014516-r59usk02 1421 39 as as IN cord-014516-r59usk02 1421 40 a a DT cord-014516-r59usk02 1421 41 significant significant JJ cord-014516-r59usk02 1421 42 prognostic prognostic JJ cord-014516-r59usk02 1421 43 factor factor NN cord-014516-r59usk02 1421 44 regarding regard VBG cord-014516-r59usk02 1421 45 the the DT cord-014516-r59usk02 1421 46 duration duration NN cord-014516-r59usk02 1421 47 of of IN cord-014516-r59usk02 1421 48 the the DT cord-014516-r59usk02 1421 49 first first JJ cord-014516-r59usk02 1421 50 remission remission NN cord-014516-r59usk02 1421 51 and and CC cord-014516-r59usk02 1421 52 the the DT cord-014516-r59usk02 1421 53 overall overall JJ cord-014516-r59usk02 1421 54 survival survival NN cord-014516-r59usk02 1421 55 time time NN cord-014516-r59usk02 1421 56 . . . cord-014516-r59usk02 1422 1 A a DT cord-014516-r59usk02 1422 2 complete complete JJ cord-014516-r59usk02 1422 3 response response NN cord-014516-r59usk02 1422 4 was be VBD cord-014516-r59usk02 1422 5 significantly significantly RB cord-014516-r59usk02 1422 6 associated associate VBN cord-014516-r59usk02 1422 7 with with IN cord-014516-r59usk02 1422 8 longer long JJR cord-014516-r59usk02 1422 9 survival survival NN cord-014516-r59usk02 1422 10 times time NNS cord-014516-r59usk02 1422 11 ( ( -LRB- cord-014516-r59usk02 1422 12 p p NN cord-014516-r59usk02 1422 13 = = SYM cord-014516-r59usk02 1422 14 0.019 0.019 CD cord-014516-r59usk02 1422 15 ) ) -RRB- cord-014516-r59usk02 1422 16 . . . cord-014516-r59usk02 1423 1 To to TO cord-014516-r59usk02 1423 2 conclude conclude VB cord-014516-r59usk02 1423 3 , , , cord-014516-r59usk02 1423 4 the the DT cord-014516-r59usk02 1423 5 DLBCL DLBCL NNP cord-014516-r59usk02 1423 6 displayed display VBD cord-014516-r59usk02 1423 7 a a DT cord-014516-r59usk02 1423 8 good good JJ cord-014516-r59usk02 1423 9 clinical clinical JJ cord-014516-r59usk02 1423 10 response response NN cord-014516-r59usk02 1423 11 to to IN cord-014516-r59usk02 1423 12 L l NN cord-014516-r59usk02 1423 13 - - HYPH cord-014516-r59usk02 1423 14 COP cop NN cord-014516-r59usk02 1423 15 protocol protocol NN cord-014516-r59usk02 1423 16 , , , cord-014516-r59usk02 1423 17 with with IN cord-014516-r59usk02 1423 18 a a DT cord-014516-r59usk02 1423 19 median median JJ cord-014516-r59usk02 1423 20 survival survival NN cord-014516-r59usk02 1423 21 time time NN cord-014516-r59usk02 1423 22 of of IN cord-014516-r59usk02 1423 23 311 311 CD cord-014516-r59usk02 1423 24 days day NNS cord-014516-r59usk02 1423 25 . . . cord-014516-r59usk02 1424 1 The the DT cord-014516-r59usk02 1424 2 only only JJ cord-014516-r59usk02 1424 3 significant significant JJ cord-014516-r59usk02 1424 4 prognostic prognostic JJ cord-014516-r59usk02 1424 5 criterion criterion NN cord-014516-r59usk02 1424 6 identified identify VBN cord-014516-r59usk02 1424 7 was be VBD cord-014516-r59usk02 1424 8 a a DT cord-014516-r59usk02 1424 9 complete complete JJ cord-014516-r59usk02 1424 10 clinical clinical JJ cord-014516-r59usk02 1424 11 response response NN cord-014516-r59usk02 1424 12 to to IN cord-014516-r59usk02 1424 13 the the DT cord-014516-r59usk02 1424 14 treatment treatment NN cord-014516-r59usk02 1424 15 . . . cord-014516-r59usk02 1425 1 A a DT cord-014516-r59usk02 1425 2 prospective prospective JJ cord-014516-r59usk02 1425 3 controlled control VBN cord-014516-r59usk02 1425 4 study study NN cord-014516-r59usk02 1425 5 on on IN cord-014516-r59usk02 1425 6 a a DT cord-014516-r59usk02 1425 7 larger large JJR cord-014516-r59usk02 1425 8 population population NN cord-014516-r59usk02 1425 9 is be VBZ cord-014516-r59usk02 1425 10 warranted warrant VBN cord-014516-r59usk02 1425 11 to to TO cord-014516-r59usk02 1425 12 confirm confirm VB cord-014516-r59usk02 1425 13 these these DT cord-014516-r59usk02 1425 14 results result NNS cord-014516-r59usk02 1425 15 . . . cord-014516-r59usk02 1426 1 No no DT cord-014516-r59usk02 1426 2 conflicts conflict NNS cord-014516-r59usk02 1426 3 of of IN cord-014516-r59usk02 1426 4 interest interest NN cord-014516-r59usk02 1426 5 reported report VBN cord-014516-r59usk02 1426 6 . . . cord-014516-r59usk02 1427 1 Canine canine JJ cord-014516-r59usk02 1427 2 histiocytic histiocytic JJ cord-014516-r59usk02 1427 3 sarcoma sarcoma NN cord-014516-r59usk02 1427 4 ( ( -LRB- cord-014516-r59usk02 1427 5 HS HS NNP cord-014516-r59usk02 1427 6 ) ) -RRB- cord-014516-r59usk02 1427 7 is be VBZ cord-014516-r59usk02 1427 8 an an DT cord-014516-r59usk02 1427 9 aggressive aggressive JJ cord-014516-r59usk02 1427 10 round round JJ cord-014516-r59usk02 1427 11 cell cell NN cord-014516-r59usk02 1427 12 neoplasm neoplasm NN cord-014516-r59usk02 1427 13 with with IN cord-014516-r59usk02 1427 14 a a DT cord-014516-r59usk02 1427 15 poor poor JJ cord-014516-r59usk02 1427 16 prognosis prognosis NN cord-014516-r59usk02 1427 17 . . . cord-014516-r59usk02 1428 1 Both both DT cord-014516-r59usk02 1428 2 lomustine lomustine JJ cord-014516-r59usk02 1428 3 and and CC cord-014516-r59usk02 1428 4 doxorubicin doxorubicin NN cord-014516-r59usk02 1428 5 have have VBP cord-014516-r59usk02 1428 6 been be VBN cord-014516-r59usk02 1428 7 evaluated evaluate VBN cord-014516-r59usk02 1428 8 as as IN cord-014516-r59usk02 1428 9 first first JJ cord-014516-r59usk02 1428 10 line line NN cord-014516-r59usk02 1428 11 chemotherapy chemotherapy NN cord-014516-r59usk02 1428 12 agents agent NNS cord-014516-r59usk02 1428 13 with with IN cord-014516-r59usk02 1428 14 response response NN cord-014516-r59usk02 1428 15 rates rate NNS cord-014516-r59usk02 1428 16 of of IN cord-014516-r59usk02 1428 17 up up IN cord-014516-r59usk02 1428 18 to to TO cord-014516-r59usk02 1428 19 46 46 CD cord-014516-r59usk02 1428 20 % % NN cord-014516-r59usk02 1428 21 and and CC cord-014516-r59usk02 1428 22 median median JJ cord-014516-r59usk02 1428 23 survival survival NN cord-014516-r59usk02 1428 24 times time NNS cord-014516-r59usk02 1428 25 around around IN cord-014516-r59usk02 1428 26 3 3 CD cord-014516-r59usk02 1428 27 - - SYM cord-014516-r59usk02 1428 28 5 5 CD cord-014516-r59usk02 1428 29 months month NNS cord-014516-r59usk02 1428 30 . . . cord-014516-r59usk02 1429 1 The the DT cord-014516-r59usk02 1429 2 aim aim NN cord-014516-r59usk02 1429 3 of of IN cord-014516-r59usk02 1429 4 this this DT cord-014516-r59usk02 1429 5 study study NN cord-014516-r59usk02 1429 6 was be VBD cord-014516-r59usk02 1429 7 to to TO cord-014516-r59usk02 1429 8 evaluate evaluate VB cord-014516-r59usk02 1429 9 the the DT cord-014516-r59usk02 1429 10 response response NN cord-014516-r59usk02 1429 11 to to IN cord-014516-r59usk02 1429 12 epirubicin epirubicin VB cord-014516-r59usk02 1429 13 in in IN cord-014516-r59usk02 1429 14 a a DT cord-014516-r59usk02 1429 15 population population NN cord-014516-r59usk02 1429 16 of of IN cord-014516-r59usk02 1429 17 dogs dog NNS cord-014516-r59usk02 1429 18 with with IN cord-014516-r59usk02 1429 19 HS HS NNP cord-014516-r59usk02 1429 20 pre pre VBN cord-014516-r59usk02 1429 21 - - VBN cord-014516-r59usk02 1429 22 treated treat VBN cord-014516-r59usk02 1429 23 with with IN cord-014516-r59usk02 1429 24 lomustine lomustine NNP cord-014516-r59usk02 1429 25 . . . cord-014516-r59usk02 1430 1 Medical medical JJ cord-014516-r59usk02 1430 2 records record NNS cord-014516-r59usk02 1430 3 of of IN cord-014516-r59usk02 1430 4 dogs dog NNS cord-014516-r59usk02 1430 5 with with IN cord-014516-r59usk02 1430 6 a a DT cord-014516-r59usk02 1430 7 diagnosis diagnosis NN cord-014516-r59usk02 1430 8 of of IN cord-014516-r59usk02 1430 9 HS HS NNP cord-014516-r59usk02 1430 10 that that WDT cord-014516-r59usk02 1430 11 were be VBD cord-014516-r59usk02 1430 12 treated treat VBN cord-014516-r59usk02 1430 13 with with IN cord-014516-r59usk02 1430 14 lomustine lomustine NNP cord-014516-r59usk02 1430 15 and and CC cord-014516-r59usk02 1430 16 subsequently subsequently RB cord-014516-r59usk02 1430 17 epirubicin epirubicin NNP cord-014516-r59usk02 1430 18 were be VBD cord-014516-r59usk02 1430 19 retrospectively retrospectively RB cord-014516-r59usk02 1430 20 evaluated evaluate VBN cord-014516-r59usk02 1430 21 . . . cord-014516-r59usk02 1431 1 Fifteen fifteen CD cord-014516-r59usk02 1431 2 dogs dog NNS cord-014516-r59usk02 1431 3 received receive VBD cord-014516-r59usk02 1431 4 lomustine lomustine NNP cord-014516-r59usk02 1431 5 followed follow VBN cord-014516-r59usk02 1431 6 by by IN cord-014516-r59usk02 1431 7 epirubicin epirubicin NNP cord-014516-r59usk02 1431 8 . . . cord-014516-r59usk02 1432 1 There there EX cord-014516-r59usk02 1432 2 was be VBD cord-014516-r59usk02 1432 3 a a DT cord-014516-r59usk02 1432 4 measureable measureable JJ cord-014516-r59usk02 1432 5 response response NN cord-014516-r59usk02 1432 6 to to IN cord-014516-r59usk02 1432 7 lomustine lomustine VB cord-014516-r59usk02 1432 8 in in IN cord-014516-r59usk02 1432 9 seven seven CD cord-014516-r59usk02 1432 10 of of IN cord-014516-r59usk02 1432 11 12 12 CD cord-014516-r59usk02 1432 12 dogs dog NNS cord-014516-r59usk02 1432 13 with with IN cord-014516-r59usk02 1432 14 evident evident JJ cord-014516-r59usk02 1432 15 disease disease NN cord-014516-r59usk02 1432 16 , , , cord-014516-r59usk02 1432 17 58 58 CD cord-014516-r59usk02 1432 18 % % NN cord-014516-r59usk02 1432 19 ( ( -LRB- cord-014516-r59usk02 1432 20 3 3 CD cord-014516-r59usk02 1432 21 CR CR NNP cord-014516-r59usk02 1432 22 & & CC cord-014516-r59usk02 1432 23 4 4 CD cord-014516-r59usk02 1432 24 PR PR NNP cord-014516-r59usk02 1432 25 ) ) -RRB- cord-014516-r59usk02 1432 26 . . . cord-014516-r59usk02 1433 1 An an DT cord-014516-r59usk02 1433 2 additional additional JJ cord-014516-r59usk02 1433 3 3 3 CD cord-014516-r59usk02 1433 4 dogs dog NNS cord-014516-r59usk02 1433 5 achieved achieve VBD cord-014516-r59usk02 1433 6 stable stable JJ cord-014516-r59usk02 1433 7 disease disease NN cord-014516-r59usk02 1433 8 for for IN cord-014516-r59usk02 1433 9 an an DT cord-014516-r59usk02 1433 10 overall overall JJ cord-014516-r59usk02 1433 11 biological biological JJ cord-014516-r59usk02 1433 12 effective effective JJ cord-014516-r59usk02 1433 13 response response NN cord-014516-r59usk02 1433 14 of of IN cord-014516-r59usk02 1433 15 83 83 CD cord-014516-r59usk02 1433 16 % % NN cord-014516-r59usk02 1433 17 . . . cord-014516-r59usk02 1434 1 Median median JJ cord-014516-r59usk02 1434 2 TTP TTP NNP cord-014516-r59usk02 1434 3 following follow VBG cord-014516-r59usk02 1434 4 lomustine lomustine NNP cord-014516-r59usk02 1434 5 could could MD cord-014516-r59usk02 1434 6 be be VB cord-014516-r59usk02 1434 7 assessed assess VBN cord-014516-r59usk02 1434 8 in in IN cord-014516-r59usk02 1434 9 12 12 CD cord-014516-r59usk02 1434 10 dogs dog NNS cord-014516-r59usk02 1434 11 and and CC cord-014516-r59usk02 1434 12 was be VBD cord-014516-r59usk02 1434 13 87 87 CD cord-014516-r59usk02 1434 14 days day NNS cord-014516-r59usk02 1435 1 ( ( -LRB- cord-014516-r59usk02 1435 2 Range Range NNP cord-014516-r59usk02 1435 3 34 34 CD cord-014516-r59usk02 1435 4 - - SYM cord-014516-r59usk02 1435 5 141 141 CD cord-014516-r59usk02 1435 6 ) ) -RRB- cord-014516-r59usk02 1435 7 . . . cord-014516-r59usk02 1436 1 All all DT cord-014516-r59usk02 1436 2 fifteen fifteen CD cord-014516-r59usk02 1436 3 dogs dog NNS cord-014516-r59usk02 1436 4 received receive VBD cord-014516-r59usk02 1436 5 epirubicin epirubicin NNP cord-014516-r59usk02 1436 6 as as IN cord-014516-r59usk02 1436 7 a a DT cord-014516-r59usk02 1436 8 rescue rescue NN cord-014516-r59usk02 1436 9 agent agent NN cord-014516-r59usk02 1436 10 : : : cord-014516-r59usk02 1436 11 nine nine CD cord-014516-r59usk02 1436 12 following follow VBG cord-014516-r59usk02 1436 13 progressive progressive JJ cord-014516-r59usk02 1436 14 disease disease NN cord-014516-r59usk02 1436 15 and and CC cord-014516-r59usk02 1436 16 three three CD cord-014516-r59usk02 1436 17 with with IN cord-014516-r59usk02 1436 18 stable stable JJ cord-014516-r59usk02 1436 19 disease disease NN cord-014516-r59usk02 1436 20 on on IN cord-014516-r59usk02 1436 21 lomustine lomustine NNP cord-014516-r59usk02 1436 22 . . . cord-014516-r59usk02 1437 1 One one CD cord-014516-r59usk02 1437 2 dog dog NN cord-014516-r59usk02 1437 3 received receive VBD cord-014516-r59usk02 1437 4 epirubicin epirubicin NN cord-014516-r59usk02 1437 5 after after IN cord-014516-r59usk02 1437 6 completing complete VBG cord-014516-r59usk02 1437 7 six six CD cord-014516-r59usk02 1437 8 doses dose NNS cord-014516-r59usk02 1437 9 of of IN cord-014516-r59usk02 1437 10 lomustine lomustine NNP cord-014516-r59usk02 1437 11 in in IN cord-014516-r59usk02 1437 12 complete complete JJ cord-014516-r59usk02 1437 13 remission remission NN cord-014516-r59usk02 1437 14 and and CC cord-014516-r59usk02 1437 15 two two CD cord-014516-r59usk02 1437 16 dogs dog NNS cord-014516-r59usk02 1437 17 in in IN cord-014516-r59usk02 1437 18 partial partial JJ cord-014516-r59usk02 1437 19 remission remission NN cord-014516-r59usk02 1437 20 changed change VBN cord-014516-r59usk02 1437 21 to to TO cord-014516-r59usk02 1437 22 epirubicin epirubicin VB cord-014516-r59usk02 1437 23 due due JJ cord-014516-r59usk02 1437 24 to to IN cord-014516-r59usk02 1437 25 hepatotoxicity hepatotoxicity NN cord-014516-r59usk02 1437 26 associated associate VBN cord-014516-r59usk02 1437 27 with with IN cord-014516-r59usk02 1437 28 lomustine lomustine NNP cord-014516-r59usk02 1437 29 . . . cord-014516-r59usk02 1438 1 Response response NN cord-014516-r59usk02 1438 2 rate rate NN cord-014516-r59usk02 1438 3 to to IN cord-014516-r59usk02 1438 4 epirubicin epirubicin NNP cord-014516-r59usk02 1438 5 was be VBD cord-014516-r59usk02 1439 1 15 15 CD cord-014516-r59usk02 1439 2 % % NN cord-014516-r59usk02 1439 3 and and CC cord-014516-r59usk02 1439 4 biologic biologic JJ cord-014516-r59usk02 1439 5 effective effective JJ cord-014516-r59usk02 1439 6 response response NN cord-014516-r59usk02 1439 7 was be VBD cord-014516-r59usk02 1439 8 61 61 CD cord-014516-r59usk02 1439 9 % % NN cord-014516-r59usk02 1439 10 ( ( -LRB- cord-014516-r59usk02 1439 11 1 1 CD cord-014516-r59usk02 1439 12 CR cr NN cord-014516-r59usk02 1439 13 , , , cord-014516-r59usk02 1439 14 1 1 CD cord-014516-r59usk02 1439 15 PR pr NN cord-014516-r59usk02 1439 16 , , , cord-014516-r59usk02 1439 17 6 6 CD cord-014516-r59usk02 1439 18 SD sd NN cord-014516-r59usk02 1439 19 , , , cord-014516-r59usk02 1439 20 5 5 CD cord-014516-r59usk02 1439 21 PD PD NNP cord-014516-r59usk02 1439 22 ) ) -RRB- cord-014516-r59usk02 1439 23 in in IN cord-014516-r59usk02 1439 24 13 13 CD cord-014516-r59usk02 1439 25 dogs dog NNS cord-014516-r59usk02 1439 26 . . . cord-014516-r59usk02 1440 1 One one CD cord-014516-r59usk02 1440 2 dog dog NN cord-014516-r59usk02 1440 3 was be VBD cord-014516-r59usk02 1440 4 euthanized euthanize VBN cord-014516-r59usk02 1440 5 due due IN cord-014516-r59usk02 1440 6 to to IN cord-014516-r59usk02 1440 7 epirubicin epirubicin VB cord-014516-r59usk02 1440 8 associated associate VBN cord-014516-r59usk02 1440 9 gastro gastro JJ cord-014516-r59usk02 1440 10 - - HYPH cord-014516-r59usk02 1440 11 intestinal intestinal JJ cord-014516-r59usk02 1440 12 toxicity toxicity NN cord-014516-r59usk02 1440 13 and and CC cord-014516-r59usk02 1440 14 1 1 CD cord-014516-r59usk02 1440 15 dog dog NN cord-014516-r59usk02 1440 16 stopped stop VBD cord-014516-r59usk02 1440 17 treatment treatment NN cord-014516-r59usk02 1440 18 with with IN cord-014516-r59usk02 1440 19 no no DT cord-014516-r59usk02 1440 20 assessment assessment NN cord-014516-r59usk02 1440 21 of of IN cord-014516-r59usk02 1440 22 response response NN cord-014516-r59usk02 1440 23 . . . cord-014516-r59usk02 1441 1 Median median JJ cord-014516-r59usk02 1441 2 duration duration NN cord-014516-r59usk02 1441 3 of of IN cord-014516-r59usk02 1441 4 response response NN cord-014516-r59usk02 1441 5 to to IN cord-014516-r59usk02 1441 6 epirubicin epirubicin NNP cord-014516-r59usk02 1441 7 was be VBD cord-014516-r59usk02 1441 8 69 69 CD cord-014516-r59usk02 1441 9 days day NNS cord-014516-r59usk02 1442 1 ( ( -LRB- cord-014516-r59usk02 1442 2 Range range NN cord-014516-r59usk02 1442 3 : : : cord-014516-r59usk02 1442 4 40 40 CD cord-014516-r59usk02 1442 5 - - SYM cord-014516-r59usk02 1442 6 347 347 CD cord-014516-r59usk02 1442 7 ) ) -RRB- cord-014516-r59usk02 1442 8 and and CC cord-014516-r59usk02 1442 9 1 1 CD cord-014516-r59usk02 1442 10 dog dog NN cord-014516-r59usk02 1442 11 is be VBZ cord-014516-r59usk02 1442 12 still still RB cord-014516-r59usk02 1442 13 alive alive JJ cord-014516-r59usk02 1442 14 and and CC cord-014516-r59usk02 1442 15 in in IN cord-014516-r59usk02 1442 16 remission remission NN cord-014516-r59usk02 1442 17 ( ( -LRB- cord-014516-r59usk02 1442 18 405 405 CD cord-014516-r59usk02 1442 19 days day NNS cord-014516-r59usk02 1442 20 ) ) -RRB- cord-014516-r59usk02 1442 21 . . . cord-014516-r59usk02 1443 1 Overall overall JJ cord-014516-r59usk02 1443 2 median median JJ cord-014516-r59usk02 1443 3 survival survival NN cord-014516-r59usk02 1443 4 time time NN cord-014516-r59usk02 1443 5 for for IN cord-014516-r59usk02 1443 6 dogs dog NNS cord-014516-r59usk02 1443 7 receiving receive VBG cord-014516-r59usk02 1443 8 epirubicin epirubicin NNP cord-014516-r59usk02 1443 9 following follow VBG cord-014516-r59usk02 1443 10 lomustine lomustine NNP cord-014516-r59usk02 1443 11 was be VBD cord-014516-r59usk02 1443 12 218 218 CD cord-014516-r59usk02 1443 13 days day NNS cord-014516-r59usk02 1444 1 ( ( -LRB- cord-014516-r59usk02 1444 2 Range range NN cord-014516-r59usk02 1444 3 : : : cord-014516-r59usk02 1444 4 27 27 CD cord-014516-r59usk02 1444 5 - - SYM cord-014516-r59usk02 1444 6 500 500 CD cord-014516-r59usk02 1444 7 ) ) -RRB- cord-014516-r59usk02 1444 8 . . . cord-014516-r59usk02 1445 1 Single single JJ cord-014516-r59usk02 1445 2 agent agent NN cord-014516-r59usk02 1445 3 epirubicin epirubicin NNP cord-014516-r59usk02 1445 4 is be VBZ cord-014516-r59usk02 1445 5 a a DT cord-014516-r59usk02 1445 6 valid valid JJ cord-014516-r59usk02 1445 7 rescue rescue NN cord-014516-r59usk02 1445 8 therapy therapy NN cord-014516-r59usk02 1445 9 after after IN cord-014516-r59usk02 1445 10 lomustine lomustine NNP cord-014516-r59usk02 1445 11 for for IN cord-014516-r59usk02 1445 12 canine canine JJ cord-014516-r59usk02 1445 13 histiocytic histiocytic JJ cord-014516-r59usk02 1445 14 sarcoma sarcoma NN cord-014516-r59usk02 1445 15 and and CC cord-014516-r59usk02 1445 16 results result NNS cord-014516-r59usk02 1445 17 in in IN cord-014516-r59usk02 1445 18 modestly modestly RB cord-014516-r59usk02 1445 19 improved improve VBN cord-014516-r59usk02 1445 20 overall overall JJ cord-014516-r59usk02 1445 21 survival survival NN cord-014516-r59usk02 1445 22 times time NNS cord-014516-r59usk02 1445 23 in in IN cord-014516-r59usk02 1445 24 responding respond VBG cord-014516-r59usk02 1445 25 patients patient NNS cord-014516-r59usk02 1445 26 . . . cord-014516-r59usk02 1446 1 The the DT cord-014516-r59usk02 1446 2 author author NN cord-014516-r59usk02 1446 3 received receive VBD cord-014516-r59usk02 1446 4 a a DT cord-014516-r59usk02 1446 5 travel travel NN cord-014516-r59usk02 1446 6 scholarship scholarship NN cord-014516-r59usk02 1446 7 from from IN cord-014516-r59usk02 1446 8 Zoetis Zoetis NNP cord-014516-r59usk02 1446 9 to to TO cord-014516-r59usk02 1446 10 attend attend VB cord-014516-r59usk02 1446 11 this this DT cord-014516-r59usk02 1446 12 congress congress NNP cord-014516-r59usk02 1446 13 . . . cord-014516-r59usk02 1447 1 The the DT cord-014516-r59usk02 1447 2 incidence incidence NN cord-014516-r59usk02 1447 3 of of IN cord-014516-r59usk02 1447 4 melanocytic melanocytic JJ cord-014516-r59usk02 1447 5 lesions lesion NNS cord-014516-r59usk02 1447 6 is be VBZ cord-014516-r59usk02 1447 7 increasing increase VBG cord-014516-r59usk02 1447 8 among among IN cord-014516-r59usk02 1447 9 canine canine JJ cord-014516-r59usk02 1447 10 population population NN cord-014516-r59usk02 1447 11 . . . cord-014516-r59usk02 1448 1 Canine canine JJ cord-014516-r59usk02 1448 2 malignant malignant JJ cord-014516-r59usk02 1448 3 melanoma melanoma NN cord-014516-r59usk02 1448 4 could could MD cord-014516-r59usk02 1448 5 have have VB cord-014516-r59usk02 1448 6 an an DT cord-014516-r59usk02 1448 7 aggressive aggressive JJ cord-014516-r59usk02 1448 8 behavior behavior NN cord-014516-r59usk02 1448 9 , , , cord-014516-r59usk02 1448 10 metastasize metastasize VBP cord-014516-r59usk02 1448 11 early early RB cord-014516-r59usk02 1448 12 in in IN cord-014516-r59usk02 1448 13 the the DT cord-014516-r59usk02 1448 14 course course NN cord-014516-r59usk02 1448 15 of of IN cord-014516-r59usk02 1448 16 the the DT cord-014516-r59usk02 1448 17 disease disease NN cord-014516-r59usk02 1448 18 and and CC cord-014516-r59usk02 1448 19 be be VB cord-014516-r59usk02 1448 20 resistant resistant JJ cord-014516-r59usk02 1448 21 to to IN cord-014516-r59usk02 1448 22 most most JJS cord-014516-r59usk02 1448 23 current current JJ cord-014516-r59usk02 1448 24 therapeutic therapeutic JJ cord-014516-r59usk02 1448 25 regimens regimen NNS cord-014516-r59usk02 1448 26 leading lead VBG cord-014516-r59usk02 1448 27 to to IN cord-014516-r59usk02 1448 28 the the DT cord-014516-r59usk02 1448 29 need need NN cord-014516-r59usk02 1448 30 of of IN cord-014516-r59usk02 1448 31 finding find VBG cord-014516-r59usk02 1448 32 markers marker NNS cord-014516-r59usk02 1448 33 with with IN cord-014516-r59usk02 1448 34 potential potential NN cord-014516-r59usk02 1448 35 as as IN cord-014516-r59usk02 1448 36 therapeutic therapeutic JJ cord-014516-r59usk02 1448 37 targets target NNS cord-014516-r59usk02 1448 38 . . . cord-014516-r59usk02 1449 1 The the DT cord-014516-r59usk02 1449 2 overexpression overexpression NN cord-014516-r59usk02 1449 3 of of IN cord-014516-r59usk02 1449 4 COX-2 COX-2 NNP cord-014516-r59usk02 1449 5 seems seem VBZ cord-014516-r59usk02 1449 6 to to TO cord-014516-r59usk02 1449 7 play play VB cord-014516-r59usk02 1449 8 a a DT cord-014516-r59usk02 1449 9 key key JJ cord-014516-r59usk02 1449 10 role role NN cord-014516-r59usk02 1449 11 in in IN cord-014516-r59usk02 1449 12 melanocytic melanocytic JJ cord-014516-r59usk02 1449 13 tumours tumour NNS cord-014516-r59usk02 1449 14 , , , cord-014516-r59usk02 1449 15 having have VBG cord-014516-r59usk02 1449 16 being be VBG cord-014516-r59usk02 1449 17 described describe VBN cord-014516-r59usk02 1449 18 an an DT cord-014516-r59usk02 1449 19 association association NN cord-014516-r59usk02 1449 20 between between IN cord-014516-r59usk02 1449 21 high high JJ cord-014516-r59usk02 1449 22 COX-2 cox-2 JJ cord-014516-r59usk02 1449 23 immunoexpression immunoexpression NN cord-014516-r59usk02 1449 24 and and CC cord-014516-r59usk02 1449 25 the the DT cord-014516-r59usk02 1449 26 malignant malignant JJ cord-014516-r59usk02 1449 27 behavior behavior NN cord-014516-r59usk02 1449 28 . . . cord-014516-r59usk02 1450 1 In in IN cord-014516-r59usk02 1450 2 order order NN cord-014516-r59usk02 1450 3 to to TO cord-014516-r59usk02 1450 4 contribute contribute VB cord-014516-r59usk02 1450 5 to to IN cord-014516-r59usk02 1450 6 the the DT cord-014516-r59usk02 1450 7 understanding understanding NN cord-014516-r59usk02 1450 8 of of IN cord-014516-r59usk02 1450 9 the the DT cord-014516-r59usk02 1450 10 role role NN cord-014516-r59usk02 1450 11 of of IN cord-014516-r59usk02 1450 12 COX-2 COX-2 NNP cord-014516-r59usk02 1450 13 in in IN cord-014516-r59usk02 1450 14 melanocytic melanocytic JJ cord-014516-r59usk02 1450 15 tumours tumour NNS cord-014516-r59usk02 1450 16 , , , cord-014516-r59usk02 1450 17 three three CD cord-014516-r59usk02 1450 18 main main JJ cord-014516-r59usk02 1450 19 pathways pathway NNS cord-014516-r59usk02 1450 20 were be VBD cord-014516-r59usk02 1450 21 investigated investigate VBN cord-014516-r59usk02 1450 22 : : : cord-014516-r59usk02 1450 23 angiogenesis angiogenesis NN cord-014516-r59usk02 1450 24 , , , cord-014516-r59usk02 1450 25 tumour tumour NN cord-014516-r59usk02 1450 26 cell cell NN cord-014516-r59usk02 1450 27 proliferation proliferation NN cord-014516-r59usk02 1450 28 and and CC cord-014516-r59usk02 1450 29 inflammatory inflammatory JJ cord-014516-r59usk02 1450 30 microenvironment microenvironment NN cord-014516-r59usk02 1450 31 ( ( -LRB- cord-014516-r59usk02 1450 32 T t NN cord-014516-r59usk02 1450 33 - - HYPH cord-014516-r59usk02 1450 34 lymphocytes lymphocyte NNS cord-014516-r59usk02 1450 35 and and CC cord-014516-r59usk02 1450 36 macrophages macrophage NNS cord-014516-r59usk02 1450 37 ) ) -RRB- cord-014516-r59usk02 1450 38 . . . cord-014516-r59usk02 1451 1 Fifty fifty CD cord-014516-r59usk02 1451 2 one one CD cord-014516-r59usk02 1451 3 ( ( -LRB- cord-014516-r59usk02 1451 4 51 51 CD cord-014516-r59usk02 1451 5 ) ) -RRB- cord-014516-r59usk02 1451 6 melanocytic melanocytic JJ cord-014516-r59usk02 1451 7 tumours tumour NNS cord-014516-r59usk02 1451 8 [ [ -LRB- cord-014516-r59usk02 1451 9 32 32 CD cord-014516-r59usk02 1451 10 cutaneous cutaneous JJ cord-014516-r59usk02 1451 11 ( ( -LRB- cord-014516-r59usk02 1451 12 12 12 CD cord-014516-r59usk02 1451 13 malignant malignant JJ cord-014516-r59usk02 1451 14 melanomas melanoma NNS cord-014516-r59usk02 1451 15 and and CC cord-014516-r59usk02 1451 16 20 20 CD cord-014516-r59usk02 1451 17 melanocytomas melanocytoma NNS cord-014516-r59usk02 1451 18 ) ) -RRB- cord-014516-r59usk02 1451 19 and and CC cord-014516-r59usk02 1451 20 19 19 CD cord-014516-r59usk02 1451 21 oral oral JJ cord-014516-r59usk02 1451 22 malignant malignant JJ cord-014516-r59usk02 1451 23 melanomas melanoma NNS cord-014516-r59usk02 1451 24 ] ] -RRB- cord-014516-r59usk02 1451 25 were be VBD cord-014516-r59usk02 1451 26 included include VBN cord-014516-r59usk02 1451 27 . . . cord-014516-r59usk02 1452 1 All all PDT cord-014516-r59usk02 1452 2 the the DT cord-014516-r59usk02 1452 3 samples sample NNS cord-014516-r59usk02 1452 4 were be VBD cord-014516-r59usk02 1452 5 submitted submit VBN cord-014516-r59usk02 1452 6 to to IN cord-014516-r59usk02 1452 7 immunohistochemical immunohistochemical JJ cord-014516-r59usk02 1452 8 staining staining NN cord-014516-r59usk02 1452 9 carried carry VBN cord-014516-r59usk02 1452 10 out out RP cord-014516-r59usk02 1452 11 by by IN cord-014516-r59usk02 1452 12 the the DT cord-014516-r59usk02 1452 13 streptavidinbiotin streptavidinbiotin NN cord-014516-r59usk02 1452 14 - - HYPH cord-014516-r59usk02 1452 15 peroxidase peroxidase NN cord-014516-r59usk02 1452 16 method method NN cord-014516-r59usk02 1452 17 , , , cord-014516-r59usk02 1452 18 with with IN cord-014516-r59usk02 1452 19 a a DT cord-014516-r59usk02 1452 20 commercial commercial JJ cord-014516-r59usk02 1452 21 detection detection NN cord-014516-r59usk02 1452 22 system system NN cord-014516-r59usk02 1452 23 with with IN cord-014516-r59usk02 1452 24 or or CC cord-014516-r59usk02 1452 25 without without IN cord-014516-r59usk02 1452 26 melanin melanin NN cord-014516-r59usk02 1452 27 blanching blanching NN cord-014516-r59usk02 1452 28 , , , cord-014516-r59usk02 1452 29 for for IN cord-014516-r59usk02 1452 30 detection detection NN cord-014516-r59usk02 1452 31 of of IN cord-014516-r59usk02 1452 32 the the DT cord-014516-r59usk02 1452 33 following follow VBG cord-014516-r59usk02 1452 34 markers marker NNS cord-014516-r59usk02 1452 35 ( ( -LRB- cord-014516-r59usk02 1452 36 COX-2 COX-2 NNP cord-014516-r59usk02 1452 37 , , , cord-014516-r59usk02 1452 38 Ki-67 Ki-67 NNP cord-014516-r59usk02 1452 39 , , , cord-014516-r59usk02 1452 40 Factor Factor NNP cord-014516-r59usk02 1452 41 VIII VIII NNP cord-014516-r59usk02 1452 42 , , , cord-014516-r59usk02 1452 43 VEGF VEGF NNP cord-014516-r59usk02 1452 44 , , , cord-014516-r59usk02 1452 45 CD3 CD3 NNP cord-014516-r59usk02 1452 46 and and CC cord-014516-r59usk02 1452 47 MAC387 MAC387 NNP cord-014516-r59usk02 1452 48 ) ) -RRB- cord-014516-r59usk02 1452 49 . . . cord-014516-r59usk02 1453 1 In in IN cord-014516-r59usk02 1453 2 melanocytic melanocytic JJ cord-014516-r59usk02 1453 3 tumours tumour NNS cord-014516-r59usk02 1453 4 ( ( -LRB- cord-014516-r59usk02 1453 5 n n NN cord-014516-r59usk02 1453 6 = = SYM cord-014516-r59usk02 1453 7 51 51 CD cord-014516-r59usk02 1453 8 ) ) -RRB- cord-014516-r59usk02 1453 9 , , , cord-014516-r59usk02 1453 10 both both DT cord-014516-r59usk02 1453 11 COX-2 cox-2 JJ cord-014516-r59usk02 1453 12 labelling labelling NN cord-014516-r59usk02 1453 13 extension extension NN cord-014516-r59usk02 1453 14 and and CC cord-014516-r59usk02 1453 15 intensity intensity NN cord-014516-r59usk02 1453 16 revealed reveal VBD cord-014516-r59usk02 1453 17 a a DT cord-014516-r59usk02 1453 18 statistically statistically RB cord-014516-r59usk02 1453 19 significant significant JJ cord-014516-r59usk02 1453 20 association association NN cord-014516-r59usk02 1453 21 with with IN cord-014516-r59usk02 1453 22 angiogenesis angiogenesis NN cord-014516-r59usk02 1453 23 by by IN cord-014516-r59usk02 1453 24 Factor factor NN cord-014516-r59usk02 1453 25 VIII VIII NNP cord-014516-r59usk02 1454 1 ( ( -LRB- cord-014516-r59usk02 1454 2 p p NN cord-014516-r59usk02 1454 3 < < XX cord-014516-r59usk02 1454 4 0,01 0,01 NN cord-014516-r59usk02 1454 5 ) ) -RRB- cord-014516-r59usk02 1454 6 , , , cord-014516-r59usk02 1454 7 VEGF VEGF NNP cord-014516-r59usk02 1454 8 ( ( -LRB- cord-014516-r59usk02 1454 9 p p NN cord-014516-r59usk02 1454 10 < < XX cord-014516-r59usk02 1454 11 0,01 0,01 NN cord-014516-r59usk02 1454 12 ) ) -RRB- cord-014516-r59usk02 1454 13 ; ; . cord-014516-r59usk02 1455 1 Ki-67 Ki-67 . cord-014516-r59usk02 1456 1 ( ( -LRB- cord-014516-r59usk02 1456 2 p p NN cord-014516-r59usk02 1456 3 < < XX cord-014516-r59usk02 1456 4 0,001 0,001 CD cord-014516-r59usk02 1456 5 ) ) -RRB- cord-014516-r59usk02 1457 1 , , , cord-014516-r59usk02 1457 2 CD3 CD3 NNP cord-014516-r59usk02 1457 3 + + CC cord-014516-r59usk02 1457 4 T T NNP cord-014516-r59usk02 1457 5 - - HYPH cord-014516-r59usk02 1457 6 lymphocytes lymphocyte NNS cord-014516-r59usk02 1458 1 ( ( -LRB- cord-014516-r59usk02 1458 2 p p NN cord-014516-r59usk02 1458 3 < < XX cord-014516-r59usk02 1458 4 0,001 0,001 CD cord-014516-r59usk02 1458 5 ) ) -RRB- cord-014516-r59usk02 1458 6 and and CC cord-014516-r59usk02 1458 7 MAC387 MAC387 NNP cord-014516-r59usk02 1459 1 ( ( -LRB- cord-014516-r59usk02 1459 2 p p NN cord-014516-r59usk02 1459 3 < < XX cord-014516-r59usk02 1459 4 0,001 0,001 CD cord-014516-r59usk02 1459 5 ) ) -RRB- cord-014516-r59usk02 1459 6 . . . cord-014516-r59usk02 1460 1 Considering consider VBG cord-014516-r59usk02 1460 2 only only RB cord-014516-r59usk02 1460 3 malignant malignant JJ cord-014516-r59usk02 1460 4 melanomas melanoma NNS cord-014516-r59usk02 1460 5 ( ( -LRB- cord-014516-r59usk02 1460 6 n n NN cord-014516-r59usk02 1460 7 = = SYM cord-014516-r59usk02 1460 8 31 31 CD cord-014516-r59usk02 1460 9 cases case NNS cord-014516-r59usk02 1460 10 ) ) -RRB- cord-014516-r59usk02 1460 11 , , , cord-014516-r59usk02 1460 12 COX-2 cox-2 JJ cord-014516-r59usk02 1460 13 labelling labelling NN cord-014516-r59usk02 1460 14 extension extension NN cord-014516-r59usk02 1460 15 revealed reveal VBD cord-014516-r59usk02 1460 16 a a DT cord-014516-r59usk02 1460 17 statistically statistically RB cord-014516-r59usk02 1460 18 significant significant JJ cord-014516-r59usk02 1460 19 association association NN cord-014516-r59usk02 1460 20 with with IN cord-014516-r59usk02 1460 21 angiogenesis angiogenesis NN cord-014516-r59usk02 1460 22 ( ( -LRB- cord-014516-r59usk02 1460 23 p p NN cord-014516-r59usk02 1460 24 = = SYM cord-014516-r59usk02 1460 25 0,041 0,041 CD cord-014516-r59usk02 1460 26 ) ) -RRB- cord-014516-r59usk02 1460 27 and and CC cord-014516-r59usk02 1460 28 CD3 CD3 NNP cord-014516-r59usk02 1460 29 + + CC cord-014516-r59usk02 1460 30 T T NNP cord-014516-r59usk02 1460 31 - - HYPH cord-014516-r59usk02 1460 32 lymphocytes lymphocyte NNS cord-014516-r59usk02 1460 33 ( ( -LRB- cord-014516-r59usk02 1460 34 p p NN cord-014516-r59usk02 1460 35 = = SYM cord-014516-r59usk02 1460 36 0,005 0,005 CD cord-014516-r59usk02 1460 37 ) ) -RRB- cord-014516-r59usk02 1460 38 . . . cord-014516-r59usk02 1461 1 COX-2 cox-2 JJ cord-014516-r59usk02 1461 2 intensity intensity NN cord-014516-r59usk02 1461 3 was be VBD cord-014516-r59usk02 1461 4 also also RB cord-014516-r59usk02 1461 5 positively positively RB cord-014516-r59usk02 1461 6 associated associate VBN cord-014516-r59usk02 1461 7 with with IN cord-014516-r59usk02 1461 8 angiogenesis angiogenesis NN cord-014516-r59usk02 1461 9 ( ( -LRB- cord-014516-r59usk02 1461 10 p p NN cord-014516-r59usk02 1461 11 = = SYM cord-014516-r59usk02 1461 12 0,008 0,008 CD cord-014516-r59usk02 1461 13 ) ) -RRB- cord-014516-r59usk02 1461 14 and and CC cord-014516-r59usk02 1461 15 with with IN cord-014516-r59usk02 1461 16 MAC387 MAC387 NNP cord-014516-r59usk02 1461 17 ( ( -LRB- cord-014516-r59usk02 1461 18 p p NN cord-014516-r59usk02 1461 19 = = SYM cord-014516-r59usk02 1461 20 0,015 0,015 CD cord-014516-r59usk02 1461 21 ) ) -RRB- cord-014516-r59usk02 1461 22 . . . cord-014516-r59usk02 1462 1 Present present JJ cord-014516-r59usk02 1462 2 study study NN cord-014516-r59usk02 1462 3 demonstrated demonstrate VBD cord-014516-r59usk02 1462 4 a a DT cord-014516-r59usk02 1462 5 link link NN cord-014516-r59usk02 1462 6 between between IN cord-014516-r59usk02 1462 7 high high JJ cord-014516-r59usk02 1462 8 COX-2 cox-2 JJ cord-014516-r59usk02 1462 9 immunoexpression immunoexpression NN cord-014516-r59usk02 1462 10 and and CC cord-014516-r59usk02 1462 11 increased increase VBN cord-014516-r59usk02 1462 12 angiogenesis angiogenesis NN cord-014516-r59usk02 1462 13 and and CC cord-014516-r59usk02 1462 14 tumoural tumoural JJ cord-014516-r59usk02 1462 15 T t NN cord-014516-r59usk02 1462 16 - - HYPH cord-014516-r59usk02 1462 17 lymphocyte lymphocyte NN cord-014516-r59usk02 1462 18 and and CC cord-014516-r59usk02 1462 19 macrophage macrophage NN cord-014516-r59usk02 1462 20 infiltration infiltration NN cord-014516-r59usk02 1462 21 in in IN cord-014516-r59usk02 1462 22 malignant malignant JJ cord-014516-r59usk02 1462 23 melanomas melanoma NNS cord-014516-r59usk02 1462 24 . . . cord-014516-r59usk02 1463 1 These these DT cord-014516-r59usk02 1463 2 findings finding NNS cord-014516-r59usk02 1463 3 reinforce reinforce VBP cord-014516-r59usk02 1463 4 the the DT cord-014516-r59usk02 1463 5 usefulness usefulness NN cord-014516-r59usk02 1463 6 of of IN cord-014516-r59usk02 1463 7 using use VBG cord-014516-r59usk02 1463 8 selective selective JJ cord-014516-r59usk02 1463 9 COX-2 COX-2 NNP cord-014516-r59usk02 1463 10 inhibitors inhibitor NNS cord-014516-r59usk02 1463 11 as as IN cord-014516-r59usk02 1463 12 a a DT cord-014516-r59usk02 1463 13 valuable valuable JJ cord-014516-r59usk02 1463 14 therapeutic therapeutic JJ cord-014516-r59usk02 1463 15 tool tool NN cord-014516-r59usk02 1463 16 in in IN cord-014516-r59usk02 1463 17 malignant malignant JJ cord-014516-r59usk02 1463 18 melanocytic melanocytic JJ cord-014516-r59usk02 1463 19 tumours tumour NNS cord-014516-r59usk02 1463 20 . . . cord-014516-r59usk02 1464 1 This this DT cord-014516-r59usk02 1464 2 study study NN cord-014516-r59usk02 1464 3 received receive VBD cord-014516-r59usk02 1464 4 financial financial JJ cord-014516-r59usk02 1464 5 support support NN cord-014516-r59usk02 1464 6 from from IN cord-014516-r59usk02 1464 7 a a DT cord-014516-r59usk02 1464 8 company company NN cord-014516-r59usk02 1464 9 ( ( -LRB- cord-014516-r59usk02 1464 10 Merial Merial NNP cord-014516-r59usk02 1464 11 ) ) -RRB- cord-014516-r59usk02 1464 12 . . . cord-014516-r59usk02 1465 1 Neuter neuter JJ cord-014516-r59usk02 1465 2 status status NN cord-014516-r59usk02 1465 3 and and CC cord-014516-r59usk02 1465 4 risk risk NN cord-014516-r59usk02 1465 5 of of IN cord-014516-r59usk02 1465 6 malignant malignant JJ cord-014516-r59usk02 1465 7 neoplasia neoplasia NN cord-014516-r59usk02 1465 8 is be VBZ cord-014516-r59usk02 1465 9 not not RB cord-014516-r59usk02 1465 10 well well RB cord-014516-r59usk02 1465 11 evaluated evaluate VBN cord-014516-r59usk02 1465 12 in in IN cord-014516-r59usk02 1465 13 the the DT cord-014516-r59usk02 1465 14 canine canine JJ cord-014516-r59usk02 1465 15 population population NN cord-014516-r59usk02 1465 16 , , , cord-014516-r59usk02 1465 17 when when WRB cord-014516-r59usk02 1465 18 excluding exclude VBG cord-014516-r59usk02 1465 19 neoplasia neoplasia NN cord-014516-r59usk02 1465 20 not not RB cord-014516-r59usk02 1465 21 normally normally RB cord-014516-r59usk02 1465 22 believed believe VBN cord-014516-r59usk02 1465 23 to to TO cord-014516-r59usk02 1465 24 be be VB cord-014516-r59usk02 1465 25 sex sex NN cord-014516-r59usk02 1465 26 - - HYPH cord-014516-r59usk02 1465 27 hormone hormone NN cord-014516-r59usk02 1465 28 dependent dependent JJ cord-014516-r59usk02 1465 29 . . . cord-014516-r59usk02 1466 1 Denmark Denmark NNP cord-014516-r59usk02 1466 2 and and CC cord-014516-r59usk02 1466 3 the the DT cord-014516-r59usk02 1466 4 Scandinavian scandinavian JJ cord-014516-r59usk02 1466 5 countries country NNS cord-014516-r59usk02 1466 6 have have VBP cord-014516-r59usk02 1466 7 a a DT cord-014516-r59usk02 1466 8 high high JJ cord-014516-r59usk02 1466 9 proportion proportion NN cord-014516-r59usk02 1466 10 of of IN cord-014516-r59usk02 1466 11 intact intact JJ cord-014516-r59usk02 1466 12 dogs dog NNS cord-014516-r59usk02 1466 13 compared compare VBN cord-014516-r59usk02 1466 14 to to IN cord-014516-r59usk02 1466 15 populations population NNS cord-014516-r59usk02 1466 16 from from IN cord-014516-r59usk02 1466 17 other other JJ cord-014516-r59usk02 1466 18 parts part NNS cord-014516-r59usk02 1466 19 of of IN cord-014516-r59usk02 1466 20 the the DT cord-014516-r59usk02 1466 21 world world NN cord-014516-r59usk02 1466 22 . . . cord-014516-r59usk02 1467 1 In in IN cord-014516-r59usk02 1467 2 the the DT cord-014516-r59usk02 1467 3 present present JJ cord-014516-r59usk02 1467 4 study study NN cord-014516-r59usk02 1467 5 it -PRON- PRP cord-014516-r59usk02 1467 6 was be VBD cord-014516-r59usk02 1467 7 hypothesized hypothesize VBN cord-014516-r59usk02 1467 8 that that IN cord-014516-r59usk02 1467 9 there there EX cord-014516-r59usk02 1467 10 would would MD cord-014516-r59usk02 1467 11 be be VB cord-014516-r59usk02 1467 12 no no DT cord-014516-r59usk02 1467 13 difference difference NN cord-014516-r59usk02 1467 14 in in IN cord-014516-r59usk02 1467 15 gender gender NN cord-014516-r59usk02 1467 16 and and CC cord-014516-r59usk02 1467 17 neuter neuter JJ cord-014516-r59usk02 1467 18 status status NN cord-014516-r59usk02 1467 19 between between IN cord-014516-r59usk02 1467 20 the the DT cord-014516-r59usk02 1467 21 population population NN cord-014516-r59usk02 1467 22 of of IN cord-014516-r59usk02 1467 23 canine canine JJ cord-014516-r59usk02 1467 24 patients patient NNS cord-014516-r59usk02 1467 25 with with IN cord-014516-r59usk02 1467 26 a a DT cord-014516-r59usk02 1467 27 non non JJ cord-014516-r59usk02 1467 28 - - JJ cord-014516-r59usk02 1467 29 sex sex JJ cord-014516-r59usk02 1467 30 - - HYPH cord-014516-r59usk02 1467 31 hormone hormone NN cord-014516-r59usk02 1467 32 dependent dependent JJ cord-014516-r59usk02 1467 33 malignant malignant JJ cord-014516-r59usk02 1467 34 neoplasia neoplasia NN cord-014516-r59usk02 1467 35 reported report VBN cord-014516-r59usk02 1467 36 to to IN cord-014516-r59usk02 1467 37 the the DT cord-014516-r59usk02 1467 38 Danish Danish NNP cord-014516-r59usk02 1467 39 Veterinary Veterinary NNP cord-014516-r59usk02 1467 40 Cancer Cancer NNP cord-014516-r59usk02 1467 41 Registry Registry NNP cord-014516-r59usk02 1467 42 and and CC cord-014516-r59usk02 1467 43 a a DT cord-014516-r59usk02 1467 44 general general JJ cord-014516-r59usk02 1467 45 population population NN cord-014516-r59usk02 1467 46 . . . cord-014516-r59usk02 1468 1 From from IN cord-014516-r59usk02 1468 2 August August NNP cord-014516-r59usk02 1468 3 2005 2005 CD cord-014516-r59usk02 1468 4 to to IN cord-014516-r59usk02 1468 5 March March NNP cord-014516-r59usk02 1468 6 2014 2014 CD cord-014516-r59usk02 1468 7 , , , cord-014516-r59usk02 1468 8 3801 3801 CD cord-014516-r59usk02 1468 9 canine canine JJ cord-014516-r59usk02 1468 10 neoplasms neoplasm NNS cord-014516-r59usk02 1468 11 were be VBD cord-014516-r59usk02 1468 12 reported report VBN cord-014516-r59usk02 1468 13 to to IN cord-014516-r59usk02 1468 14 the the DT cord-014516-r59usk02 1468 15 Danish Danish NNP cord-014516-r59usk02 1468 16 Veterinary Veterinary NNP cord-014516-r59usk02 1468 17 Cancer Cancer NNP cord-014516-r59usk02 1468 18 Registry Registry NNP cord-014516-r59usk02 1468 19 . . . cord-014516-r59usk02 1469 1 The the DT cord-014516-r59usk02 1469 2 total total JJ cord-014516-r59usk02 1469 3 number number NN cord-014516-r59usk02 1469 4 of of IN cord-014516-r59usk02 1469 5 malignant malignant JJ cord-014516-r59usk02 1469 6 ( ( -LRB- cord-014516-r59usk02 1469 7 1788 1788 CD cord-014516-r59usk02 1469 8 ) ) -RRB- cord-014516-r59usk02 1469 9 and and CC cord-014516-r59usk02 1469 10 benign benign JJ cord-014516-r59usk02 1469 11 ( ( -LRB- cord-014516-r59usk02 1469 12 1953 1953 CD cord-014516-r59usk02 1469 13 ) ) -RRB- cord-014516-r59usk02 1469 14 were be VBD cord-014516-r59usk02 1469 15 comparable comparable JJ cord-014516-r59usk02 1469 16 ( ( -LRB- cord-014516-r59usk02 1469 17 42 42 CD cord-014516-r59usk02 1469 18 % % NN cord-014516-r59usk02 1469 19 and and CC cord-014516-r59usk02 1469 20 46 46 CD cord-014516-r59usk02 1469 21 % % NN cord-014516-r59usk02 1469 22 ) ) -RRB- cord-014516-r59usk02 1469 23 . . . cord-014516-r59usk02 1470 1 Malignant malignant JJ cord-014516-r59usk02 1470 2 neoplasms neoplasm NNS cord-014516-r59usk02 1470 3 totalled total VBD cord-014516-r59usk02 1470 4 1262 1262 CD cord-014516-r59usk02 1470 5 , , , cord-014516-r59usk02 1470 6 when when WRB cord-014516-r59usk02 1470 7 tumors tumor NNS cord-014516-r59usk02 1470 8 from from IN cord-014516-r59usk02 1470 9 areas area NNS cord-014516-r59usk02 1470 10 of of IN cord-014516-r59usk02 1470 11 distribution distribution NN cord-014516-r59usk02 1470 12 with with IN cord-014516-r59usk02 1470 13 known know VBN cord-014516-r59usk02 1470 14 sex sex NN cord-014516-r59usk02 1470 15 - - HYPH cord-014516-r59usk02 1470 16 hormone hormone NN cord-014516-r59usk02 1470 17 dependency dependency NN cord-014516-r59usk02 1470 18 ( ( -LRB- cord-014516-r59usk02 1470 19 reproductive reproductive JJ cord-014516-r59usk02 1470 20 organs organ NNS cord-014516-r59usk02 1470 21 , , , cord-014516-r59usk02 1470 22 mammary mammary JJ cord-014516-r59usk02 1470 23 gland gland NN cord-014516-r59usk02 1470 24 , , , cord-014516-r59usk02 1470 25 perineal perineal NN cord-014516-r59usk02 1470 26 ) ) -RRB- cord-014516-r59usk02 1470 27 , , , cord-014516-r59usk02 1470 28 and and CC cord-014516-r59usk02 1470 29 cases case NNS cord-014516-r59usk02 1470 30 with with IN cord-014516-r59usk02 1470 31 unknown unknown JJ cord-014516-r59usk02 1470 32 area area NN cord-014516-r59usk02 1470 33 of of IN cord-014516-r59usk02 1470 34 distribution distribution NN cord-014516-r59usk02 1470 35 were be VBD cord-014516-r59usk02 1470 36 excluded exclude VBN cord-014516-r59usk02 1470 37 . . . cord-014516-r59usk02 1471 1 The the DT cord-014516-r59usk02 1471 2 overall overall JJ cord-014516-r59usk02 1471 3 distribution distribution NN cord-014516-r59usk02 1471 4 of of IN cord-014516-r59usk02 1471 5 malignant malignant JJ cord-014516-r59usk02 1471 6 neoplasia neoplasia NN cord-014516-r59usk02 1471 7 was be VBD cord-014516-r59usk02 1471 8 481 481 CD cord-014516-r59usk02 1471 9 ( ( -LRB- cord-014516-r59usk02 1471 10 38 38 CD cord-014516-r59usk02 1471 11 % % NN cord-014516-r59usk02 1471 12 ) ) -RRB- cord-014516-r59usk02 1472 1 intact intact JJ cord-014516-r59usk02 1472 2 male male JJ cord-014516-r59usk02 1472 3 dogs dog NNS cord-014516-r59usk02 1472 4 , , , cord-014516-r59usk02 1472 5 157 157 CD cord-014516-r59usk02 1472 6 ( ( -LRB- cord-014516-r59usk02 1472 7 12.5 12.5 CD cord-014516-r59usk02 1472 8 % % NN cord-014516-r59usk02 1472 9 ) ) -RRB- cord-014516-r59usk02 1472 10 neutered neuter VBN cord-014516-r59usk02 1472 11 male male JJ cord-014516-r59usk02 1472 12 dogs dog NNS cord-014516-r59usk02 1472 13 , , , cord-014516-r59usk02 1472 14 404 404 CD cord-014516-r59usk02 1472 15 ( ( -LRB- cord-014516-r59usk02 1472 16 32 32 CD cord-014516-r59usk02 1472 17 % % NN cord-014516-r59usk02 1472 18 ) ) -RRB- cord-014516-r59usk02 1472 19 intact intact JJ cord-014516-r59usk02 1472 20 female female JJ cord-014516-r59usk02 1472 21 dogs dog NNS cord-014516-r59usk02 1472 22 and and CC cord-014516-r59usk02 1472 23 220 220 CD cord-014516-r59usk02 1472 24 ( ( -LRB- cord-014516-r59usk02 1472 25 17.5 17.5 CD cord-014516-r59usk02 1472 26 % % NN cord-014516-r59usk02 1472 27 ) ) -RRB- cord-014516-r59usk02 1472 28 neutered neuter VBN cord-014516-r59usk02 1472 29 female female JJ cord-014516-r59usk02 1472 30 dogs dog NNS cord-014516-r59usk02 1472 31 . . . cord-014516-r59usk02 1473 1 The the DT cord-014516-r59usk02 1473 2 distribution distribution NN cord-014516-r59usk02 1473 3 was be VBD cord-014516-r59usk02 1473 4 even even RB cord-014516-r59usk02 1473 5 between between IN cord-014516-r59usk02 1473 6 male male JJ cord-014516-r59usk02 1473 7 and and CC cord-014516-r59usk02 1473 8 female female JJ cord-014516-r59usk02 1473 9 dogs dog NNS cord-014516-r59usk02 1473 10 ( ( -LRB- cord-014516-r59usk02 1473 11 50.5 50.5 CD cord-014516-r59usk02 1473 12 % % NN cord-014516-r59usk02 1473 13 and and CC cord-014516-r59usk02 1473 14 49.5 49.5 CD cord-014516-r59usk02 1473 15 % % NN cord-014516-r59usk02 1473 16 ) ) -RRB- cord-014516-r59usk02 1473 17 . . . cord-014516-r59usk02 1474 1 Compared compare VBN cord-014516-r59usk02 1474 2 to to IN cord-014516-r59usk02 1474 3 a a DT cord-014516-r59usk02 1474 4 known know VBN cord-014516-r59usk02 1474 5 standard standard JJ cord-014516-r59usk02 1474 6 population population NN cord-014516-r59usk02 1474 7 of of IN cord-014516-r59usk02 1474 8 dogs dog NNS cord-014516-r59usk02 1474 9 , , , cord-014516-r59usk02 1474 10 there there EX cord-014516-r59usk02 1474 11 was be VBD cord-014516-r59usk02 1474 12 an an DT cord-014516-r59usk02 1474 13 overall overall NN cord-014516-r59usk02 1474 14 statistically statistically RB cord-014516-r59usk02 1474 15 significant significant JJ cord-014516-r59usk02 1474 16 association association NN cord-014516-r59usk02 1474 17 of of IN cord-014516-r59usk02 1474 18 malignant malignant JJ cord-014516-r59usk02 1474 19 neoplasia neoplasia NN cord-014516-r59usk02 1474 20 with with IN cord-014516-r59usk02 1474 21 neuter neuter JJ cord-014516-r59usk02 1474 22 status status NN cord-014516-r59usk02 1474 23 in in IN cord-014516-r59usk02 1474 24 both both DT cord-014516-r59usk02 1474 25 sexes sex NNS cord-014516-r59usk02 1474 26 . . . cord-014516-r59usk02 1475 1 For for IN cord-014516-r59usk02 1475 2 both both DT cord-014516-r59usk02 1475 3 genders gender NNS cord-014516-r59usk02 1475 4 this this DT cord-014516-r59usk02 1475 5 was be VBD cord-014516-r59usk02 1475 6 significant significant JJ cord-014516-r59usk02 1475 7 for for IN cord-014516-r59usk02 1475 8 lymphoma lymphoma NN cord-014516-r59usk02 1475 9 , , , cord-014516-r59usk02 1475 10 mast mast NN cord-014516-r59usk02 1475 11 cell cell NN cord-014516-r59usk02 1475 12 tumors tumor NNS cord-014516-r59usk02 1475 13 and and CC cord-014516-r59usk02 1475 14 osteosarcomas osteosarcoma NNS cord-014516-r59usk02 1475 15 , , , cord-014516-r59usk02 1475 16 . . . cord-014516-r59usk02 1476 1 For for IN cord-014516-r59usk02 1476 2 neutered neutered JJ cord-014516-r59usk02 1476 3 females female NNS cord-014516-r59usk02 1476 4 , , , cord-014516-r59usk02 1476 5 but but CC cord-014516-r59usk02 1476 6 not not RB cord-014516-r59usk02 1476 7 males male NNS cord-014516-r59usk02 1476 8 , , , cord-014516-r59usk02 1476 9 there there EX cord-014516-r59usk02 1476 10 was be VBD cord-014516-r59usk02 1476 11 increased increase VBN cord-014516-r59usk02 1476 12 risk risk NN cord-014516-r59usk02 1476 13 of of IN cord-014516-r59usk02 1476 14 hemangiosarcoma hemangiosarcoma NN cord-014516-r59usk02 1476 15 , , , cord-014516-r59usk02 1476 16 squamous squamous JJ cord-014516-r59usk02 1476 17 cell cell NN cord-014516-r59usk02 1476 18 carcinoma carcinoma NN cord-014516-r59usk02 1476 19 and and CC cord-014516-r59usk02 1476 20 malignant malignant JJ cord-014516-r59usk02 1476 21 melanoma melanoma NN cord-014516-r59usk02 1476 22 . . . cord-014516-r59usk02 1477 1 These these DT cord-014516-r59usk02 1477 2 findings finding NNS cord-014516-r59usk02 1477 3 indicate indicate VBP cord-014516-r59usk02 1477 4 that that IN cord-014516-r59usk02 1477 5 there there EX cord-014516-r59usk02 1477 6 might may MD cord-014516-r59usk02 1477 7 be be VB cord-014516-r59usk02 1477 8 an an DT cord-014516-r59usk02 1477 9 association association NN cord-014516-r59usk02 1477 10 between between IN cord-014516-r59usk02 1477 11 neuter neuter JJ cord-014516-r59usk02 1477 12 status status NN cord-014516-r59usk02 1477 13 and and CC cord-014516-r59usk02 1477 14 development development NN cord-014516-r59usk02 1477 15 of of IN cord-014516-r59usk02 1477 16 malignant malignant JJ cord-014516-r59usk02 1477 17 neoplasia neoplasia NNS cord-014516-r59usk02 1477 18 but but CC cord-014516-r59usk02 1477 19 larger large JJR cord-014516-r59usk02 1477 20 prospective prospective JJ cord-014516-r59usk02 1477 21 studies study NNS cord-014516-r59usk02 1477 22 are be VBP cord-014516-r59usk02 1477 23 needed need VBN cord-014516-r59usk02 1477 24 to to TO cord-014516-r59usk02 1477 25 evaluate evaluate VB cord-014516-r59usk02 1477 26 the the DT cord-014516-r59usk02 1477 27 risk risk NN cord-014516-r59usk02 1477 28 of of IN cord-014516-r59usk02 1477 29 non non JJ cord-014516-r59usk02 1477 30 - - JJ cord-014516-r59usk02 1477 31 sex sex JJ cord-014516-r59usk02 1477 32 hormone hormone NN cord-014516-r59usk02 1477 33 dependent dependent JJ cord-014516-r59usk02 1477 34 cancers cancer NNS cord-014516-r59usk02 1477 35 in in IN cord-014516-r59usk02 1477 36 neutered neutered JJ cord-014516-r59usk02 1477 37 dogs dog NNS cord-014516-r59usk02 1477 38 . . . cord-014516-r59usk02 1478 1 No no DT cord-014516-r59usk02 1478 2 conflicts conflict NNS cord-014516-r59usk02 1478 3 of of IN cord-014516-r59usk02 1478 4 interest interest NN cord-014516-r59usk02 1478 5 reported report VBN cord-014516-r59usk02 1478 6 . . . cord-014516-r59usk02 1479 1 Serum serum NN cord-014516-r59usk02 1479 2 acute acute JJ cord-014516-r59usk02 1479 3 phase phase NN cord-014516-r59usk02 1479 4 proteins protein NNS cord-014516-r59usk02 1479 5 ( ( -LRB- cord-014516-r59usk02 1479 6 APPs app NNS cord-014516-r59usk02 1479 7 ) ) -RRB- cord-014516-r59usk02 1479 8 are be VBP cord-014516-r59usk02 1479 9 considered consider VBN cord-014516-r59usk02 1479 10 biomarkers biomarker NNS cord-014516-r59usk02 1479 11 of of IN cord-014516-r59usk02 1479 12 the the DT cord-014516-r59usk02 1479 13 acute acute JJ cord-014516-r59usk02 1479 14 phase phase NN cord-014516-r59usk02 1479 15 reaction reaction NN cord-014516-r59usk02 1479 16 , , , cord-014516-r59usk02 1479 17 and and CC cord-014516-r59usk02 1479 18 are be VBP cord-014516-r59usk02 1479 19 being be VBG cord-014516-r59usk02 1479 20 increasingly increasingly RB cord-014516-r59usk02 1479 21 used use VBN cord-014516-r59usk02 1479 22 in in IN cord-014516-r59usk02 1479 23 human human JJ cord-014516-r59usk02 1479 24 and and CC cord-014516-r59usk02 1479 25 veterinary veterinary JJ cord-014516-r59usk02 1479 26 medicine medicine NN cord-014516-r59usk02 1479 27 in in IN cord-014516-r59usk02 1479 28 diagnosis diagnosis NN cord-014516-r59usk02 1479 29 and and CC cord-014516-r59usk02 1479 30 monitoring monitoring NN cord-014516-r59usk02 1479 31 of of IN cord-014516-r59usk02 1479 32 neoplastic neoplastic JJ cord-014516-r59usk02 1479 33 diseases disease NNS cord-014516-r59usk02 1479 34 . . . cord-014516-r59usk02 1480 1 In in IN cord-014516-r59usk02 1480 2 the the DT cord-014516-r59usk02 1480 3 cat cat NN cord-014516-r59usk02 1480 4 , , , cord-014516-r59usk02 1480 5 serum serum NN cord-014516-r59usk02 1480 6 amyloid amyloid NN cord-014516-r59usk02 1480 7 A A NNP cord-014516-r59usk02 1480 8 ( ( -LRB- cord-014516-r59usk02 1480 9 SAA SAA NNP cord-014516-r59usk02 1480 10 ) ) -RRB- cord-014516-r59usk02 1480 11 is be VBZ cord-014516-r59usk02 1480 12 considered consider VBN cord-014516-r59usk02 1480 13 a a DT cord-014516-r59usk02 1480 14 positive positive JJ cord-014516-r59usk02 1480 15 major major JJ cord-014516-r59usk02 1480 16 APP app NN cord-014516-r59usk02 1480 17 , , , cord-014516-r59usk02 1480 18 haptoglobin haptoglobin NN cord-014516-r59usk02 1480 19 ( ( -LRB- cord-014516-r59usk02 1480 20 Hp Hp NNP cord-014516-r59usk02 1480 21 ) ) -RRB- cord-014516-r59usk02 1480 22 a a DT cord-014516-r59usk02 1480 23 moderate moderate JJ cord-014516-r59usk02 1480 24 APP app NN cord-014516-r59usk02 1480 25 , , , cord-014516-r59usk02 1480 26 and and CC cord-014516-r59usk02 1480 27 albumin albumin NN cord-014516-r59usk02 1480 28 and and CC cord-014516-r59usk02 1480 29 insulin insulin NN cord-014516-r59usk02 1480 30 - - HYPH cord-014516-r59usk02 1480 31 like like JJ cord-014516-r59usk02 1480 32 growth growth NN cord-014516-r59usk02 1480 33 factor-1(IGF-1 factor-1(IGF-1 NNP cord-014516-r59usk02 1480 34 ) ) -RRB- cord-014516-r59usk02 1480 35 negative negative JJ cord-014516-r59usk02 1480 36 APPs app NNS cord-014516-r59usk02 1480 37 . . . cord-014516-r59usk02 1481 1 The the DT cord-014516-r59usk02 1481 2 aim aim NN cord-014516-r59usk02 1481 3 of of IN cord-014516-r59usk02 1481 4 the the DT cord-014516-r59usk02 1481 5 present present JJ cord-014516-r59usk02 1481 6 study study NN cord-014516-r59usk02 1481 7 was be VBD cord-014516-r59usk02 1481 8 to to TO cord-014516-r59usk02 1481 9 characterize characterize VB cord-014516-r59usk02 1481 10 the the DT cord-014516-r59usk02 1481 11 APPs app NNS cord-014516-r59usk02 1481 12 response response NN cord-014516-r59usk02 1481 13 in in IN cord-014516-r59usk02 1481 14 cats cat NNS cord-014516-r59usk02 1481 15 with with IN cord-014516-r59usk02 1481 16 mammary mammary JJ cord-014516-r59usk02 1481 17 tumours tumour NNS cord-014516-r59usk02 1481 18 . . . cord-014516-r59usk02 1482 1 For for IN cord-014516-r59usk02 1482 2 that that DT cord-014516-r59usk02 1482 3 purpose purpose NN cord-014516-r59usk02 1482 4 , , , cord-014516-r59usk02 1482 5 SAA SAA NNP cord-014516-r59usk02 1482 6 , , , cord-014516-r59usk02 1482 7 Hp Hp NNP cord-014516-r59usk02 1482 8 , , , cord-014516-r59usk02 1482 9 IGF-1 IGF-1 NNP cord-014516-r59usk02 1482 10 and and CC cord-014516-r59usk02 1482 11 albumin albumin NN cord-014516-r59usk02 1482 12 serum serum NN cord-014516-r59usk02 1482 13 concentrations concentration NNS cord-014516-r59usk02 1482 14 were be VBD cord-014516-r59usk02 1482 15 determined determine VBN cord-014516-r59usk02 1482 16 in in IN cord-014516-r59usk02 1482 17 20 20 CD cord-014516-r59usk02 1482 18 female female JJ cord-014516-r59usk02 1482 19 cats cat NNS cord-014516-r59usk02 1482 20 with with IN cord-014516-r59usk02 1482 21 malignant malignant JJ cord-014516-r59usk02 1482 22 mammary mammary JJ cord-014516-r59usk02 1482 23 tumours tumour NNS cord-014516-r59usk02 1482 24 . . . cord-014516-r59usk02 1483 1 Cats cat NNS cord-014516-r59usk02 1483 2 with with IN cord-014516-r59usk02 1483 3 history history NN cord-014516-r59usk02 1483 4 of of IN cord-014516-r59usk02 1483 5 previous previous JJ cord-014516-r59usk02 1483 6 tumours tumour NNS cord-014516-r59usk02 1483 7 or or CC cord-014516-r59usk02 1483 8 with with IN cord-014516-r59usk02 1483 9 concomitant concomitant JJ cord-014516-r59usk02 1483 10 tumours tumour NNS cord-014516-r59usk02 1483 11 or or CC cord-014516-r59usk02 1483 12 other other JJ cord-014516-r59usk02 1483 13 diseases disease NNS cord-014516-r59usk02 1483 14 were be VBD cord-014516-r59usk02 1483 15 excluded exclude VBN cord-014516-r59usk02 1483 16 . . . cord-014516-r59usk02 1484 1 Information information NN cord-014516-r59usk02 1484 2 on on IN cord-014516-r59usk02 1484 3 cats cat NNS cord-014516-r59usk02 1484 4 age age NN cord-014516-r59usk02 1484 5 , , , cord-014516-r59usk02 1484 6 gender gender NN cord-014516-r59usk02 1484 7 , , , cord-014516-r59usk02 1484 8 breed breed NN cord-014516-r59usk02 1484 9 , , , cord-014516-r59usk02 1484 10 tumour tumour NN cord-014516-r59usk02 1484 11 type type NN cord-014516-r59usk02 1484 12 , , , cord-014516-r59usk02 1484 13 histological histological JJ cord-014516-r59usk02 1484 14 grade grade NN cord-014516-r59usk02 1484 15 , , , cord-014516-r59usk02 1484 16 tumour tumour NN cord-014516-r59usk02 1484 17 size size NN cord-014516-r59usk02 1484 18 and and CC cord-014516-r59usk02 1484 19 location location NN cord-014516-r59usk02 1484 20 , , , cord-014516-r59usk02 1484 21 skin skin NN cord-014516-r59usk02 1484 22 ulceration ulceration NN cord-014516-r59usk02 1484 23 , , , cord-014516-r59usk02 1484 24 vascular vascular JJ cord-014516-r59usk02 1484 25 neoplastic neoplastic JJ cord-014516-r59usk02 1484 26 infiltration infiltration NN cord-014516-r59usk02 1484 27 , , , cord-014516-r59usk02 1484 28 necrosis necrosis NN cord-014516-r59usk02 1484 29 , , , cord-014516-r59usk02 1484 30 metastasis metastasis NN cord-014516-r59usk02 1484 31 to to IN cord-014516-r59usk02 1484 32 regional regional JJ cord-014516-r59usk02 1484 33 lymph lymph NN cord-014516-r59usk02 1484 34 nodes node NNS cord-014516-r59usk02 1484 35 , , , cord-014516-r59usk02 1484 36 thoracic thoracic JJ cord-014516-r59usk02 1484 37 or or CC cord-014516-r59usk02 1484 38 abdominal abdominal JJ cord-014516-r59usk02 1484 39 organs organ NNS cord-014516-r59usk02 1484 40 , , , cord-014516-r59usk02 1484 41 and and CC cord-014516-r59usk02 1484 42 survival survival NN cord-014516-r59usk02 1484 43 time time NN cord-014516-r59usk02 1484 44 from from IN cord-014516-r59usk02 1484 45 diagnosis diagnosis NN cord-014516-r59usk02 1484 46 was be VBD cord-014516-r59usk02 1484 47 assessed assess VBN cord-014516-r59usk02 1484 48 . . . cord-014516-r59usk02 1485 1 Blood blood NN cord-014516-r59usk02 1485 2 samples sample NNS cord-014516-r59usk02 1485 3 were be VBD cord-014516-r59usk02 1485 4 collected collect VBN cord-014516-r59usk02 1485 5 before before IN cord-014516-r59usk02 1485 6 surgery surgery NN cord-014516-r59usk02 1485 7 in in IN cord-014516-r59usk02 1485 8 all all DT cord-014516-r59usk02 1485 9 cats cat NNS cord-014516-r59usk02 1485 10 , , , cord-014516-r59usk02 1485 11 and and CC cord-014516-r59usk02 1485 12 whenever whenever WRB cord-014516-r59usk02 1485 13 possible possible JJ cord-014516-r59usk02 1485 14 , , , cord-014516-r59usk02 1485 15 serial serial JJ cord-014516-r59usk02 1485 16 samples sample NNS cord-014516-r59usk02 1485 17 collected collect VBN cord-014516-r59usk02 1485 18 on on IN cord-014516-r59usk02 1485 19 control control NN cord-014516-r59usk02 1485 20 visits visit NNS cord-014516-r59usk02 1485 21 . . . cord-014516-r59usk02 1486 1 Owners owner NNS cord-014516-r59usk02 1486 2 gave give VBD cord-014516-r59usk02 1486 3 informed informed JJ cord-014516-r59usk02 1486 4 consent consent NN cord-014516-r59usk02 1486 5 . . . cord-014516-r59usk02 1487 1 Studied study VBN cord-014516-r59usk02 1487 2 population population NN cord-014516-r59usk02 1487 3 included include VBD cord-014516-r59usk02 1487 4 20 20 CD cord-014516-r59usk02 1487 5 domestic domestic JJ cord-014516-r59usk02 1487 6 short short JJ cord-014516-r59usk02 1487 7 - - HYPH cord-014516-r59usk02 1487 8 haired haired JJ cord-014516-r59usk02 1487 9 cats cat NNS cord-014516-r59usk02 1487 10 with with IN cord-014516-r59usk02 1487 11 ages age NNS cord-014516-r59usk02 1487 12 ranging range VBG cord-014516-r59usk02 1487 13 from from IN cord-014516-r59usk02 1487 14 eight eight CD cord-014516-r59usk02 1487 15 to to TO cord-014516-r59usk02 1487 16 17 17 CD cord-014516-r59usk02 1487 17 years year NNS cord-014516-r59usk02 1487 18 ( ( -LRB- cord-014516-r59usk02 1487 19 11,5 11,5 CD cord-014516-r59usk02 1487 20 + + CC cord-014516-r59usk02 1487 21 /-2,7 /-2,7 NNP cord-014516-r59usk02 1487 22 ) ) -RRB- cord-014516-r59usk02 1487 23 . . . cord-014516-r59usk02 1488 1 All all DT cord-014516-r59usk02 1488 2 had have VBD cord-014516-r59usk02 1488 3 carcinomas carcinoma NNS cord-014516-r59usk02 1488 4 , , , cord-014516-r59usk02 1488 5 including include VBG cord-014516-r59usk02 1488 6 solid solid JJ cord-014516-r59usk02 1488 7 carcinomas carcinoma NNS cord-014516-r59usk02 1488 8 ( ( -LRB- cord-014516-r59usk02 1488 9 n n NN cord-014516-r59usk02 1488 10 = = SYM cord-014516-r59usk02 1488 11 10 10 CD cord-014516-r59usk02 1488 12 ) ) -RRB- cord-014516-r59usk02 1488 13 , , , cord-014516-r59usk02 1488 14 tubulopapillary tubulopapillary JJ cord-014516-r59usk02 1488 15 carcinomas carcinoma NNS cord-014516-r59usk02 1488 16 ( ( -LRB- cord-014516-r59usk02 1488 17 n n NN cord-014516-r59usk02 1488 18 = = SYM cord-014516-r59usk02 1488 19 8) 8) NN cord-014516-r59usk02 1488 20 , , , cord-014516-r59usk02 1488 21 one one CD cord-014516-r59usk02 1488 22 cribiform cribiform NN cord-014516-r59usk02 1488 23 carcinoma carcinoma NN cord-014516-r59usk02 1488 24 and and CC cord-014516-r59usk02 1488 25 one one CD cord-014516-r59usk02 1488 26 carcinosarcoma carcinosarcoma NN cord-014516-r59usk02 1488 27 . . . cord-014516-r59usk02 1489 1 At at IN cord-014516-r59usk02 1489 2 the the DT cord-014516-r59usk02 1489 3 time time NN cord-014516-r59usk02 1489 4 of of IN cord-014516-r59usk02 1489 5 diagnosis diagnosis NN cord-014516-r59usk02 1489 6 , , , cord-014516-r59usk02 1489 7 70 70 CD cord-014516-r59usk02 1489 8 % % NN cord-014516-r59usk02 1489 9 of of IN cord-014516-r59usk02 1489 10 cats cat NNS cord-014516-r59usk02 1489 11 had have VBD cord-014516-r59usk02 1489 12 an an DT cord-014516-r59usk02 1489 13 increase increase NN cord-014516-r59usk02 1489 14 in in IN cord-014516-r59usk02 1489 15 serum serum NN cord-014516-r59usk02 1489 16 concentration concentration NN cord-014516-r59usk02 1489 17 of of IN cord-014516-r59usk02 1489 18 Hp Hp NNP cord-014516-r59usk02 1489 19 and and CC cord-014516-r59usk02 1489 20 20 20 CD cord-014516-r59usk02 1489 21 % % NN cord-014516-r59usk02 1489 22 of of IN cord-014516-r59usk02 1489 23 SAA SAA NNP cord-014516-r59usk02 1489 24 , , , cord-014516-r59usk02 1489 25 and and CC cord-014516-r59usk02 1489 26 25 25 CD cord-014516-r59usk02 1489 27 % % NN cord-014516-r59usk02 1489 28 had have VBD cord-014516-r59usk02 1489 29 a a DT cord-014516-r59usk02 1489 30 decrease decrease NN cord-014516-r59usk02 1489 31 in in IN cord-014516-r59usk02 1489 32 concentration concentration NN cord-014516-r59usk02 1489 33 of of IN cord-014516-r59usk02 1489 34 albumin albumin NN cord-014516-r59usk02 1489 35 . . . cord-014516-r59usk02 1490 1 Mean mean JJ cord-014516-r59usk02 1490 2 and and CC cord-014516-r59usk02 1490 3 standard standard JJ cord-014516-r59usk02 1490 4 deviation deviation NN cord-014516-r59usk02 1490 5 values value NNS cord-014516-r59usk02 1490 6 were be VBD cord-014516-r59usk02 1490 7 of of IN cord-014516-r59usk02 1490 8 2,76 2,76 CD cord-014516-r59usk02 1491 1 + + CC cord-014516-r59usk02 1491 2 /-0,48 /-0,48 . cord-014516-r59usk02 1492 1 g g NNP cord-014516-r59usk02 1492 2 / / SYM cord-014516-r59usk02 1492 3 dl dl NNP cord-014516-r59usk02 1492 4 for for IN cord-014516-r59usk02 1492 5 albumin albumin NN cord-014516-r59usk02 1493 1 ( ( -LRB- cord-014516-r59usk02 1493 2 reference reference NN cord-014516-r59usk02 1493 3 range range NN cord-014516-r59usk02 1493 4 2,5 2,5 CD cord-014516-r59usk02 1493 5 - - HYPH cord-014516-r59usk02 1493 6 3,6 3,6 CD cord-014516-r59usk02 1493 7 g/ g/ NNP cord-014516-r59usk02 1493 8 dl dl NNP cord-014516-r59usk02 1493 9 ) ) -RRB- cord-014516-r59usk02 1493 10 , , . cord-014516-r59usk02 1494 1 319,12 319,12 NNP cord-014516-r59usk02 1494 2 + + CC cord-014516-r59usk02 1494 3 /-162,89 /-162,89 NNP cord-014516-r59usk02 1494 4 lg lg NNP cord-014516-r59usk02 1494 5 / / SYM cord-014516-r59usk02 1494 6 dl dl NNP cord-014516-r59usk02 1494 7 for for IN cord-014516-r59usk02 1494 8 IGF-1 IGF-1 NNP cord-014516-r59usk02 1494 9 , , , cord-014516-r59usk02 1495 1 12,95 12,95 CD cord-014516-r59usk02 1495 2 + + CC cord-014516-r59usk02 1495 3 /-29,76 /-29,76 CD cord-014516-r59usk02 1495 4 lg lg NNP cord-014516-r59usk02 1495 5 / / SYM cord-014516-r59usk02 1495 6 ml ml NN cord-014516-r59usk02 1495 7 for for IN cord-014516-r59usk02 1495 8 SAA SAA NNP cord-014516-r59usk02 1496 1 ( ( -LRB- cord-014516-r59usk02 1496 2 reference reference NN cord-014516-r59usk02 1496 3 value value NN cord-014516-r59usk02 1497 1 ˂5 ˂5 NNP cord-014516-r59usk02 1497 2 lg lg NNP cord-014516-r59usk02 1497 3 / / SYM cord-014516-r59usk02 1497 4 ml ml NNP cord-014516-r59usk02 1497 5 ) ) -RRB- cord-014516-r59usk02 1497 6 , , , cord-014516-r59usk02 1497 7 and and CC cord-014516-r59usk02 1497 8 5,12 5,12 CD cord-014516-r59usk02 1498 1 + + CC cord-014516-r59usk02 1498 2 /-3,20 /-3,20 . cord-014516-r59usk02 1499 1 g g NNP cord-014516-r59usk02 1499 2 / / SYM cord-014516-r59usk02 1499 3 l l NN cord-014516-r59usk02 1499 4 for for IN cord-014516-r59usk02 1499 5 Hp Hp NNP cord-014516-r59usk02 1499 6 ( ( -LRB- cord-014516-r59usk02 1499 7 reference reference NN cord-014516-r59usk02 1499 8 value value NN cord-014516-r59usk02 1499 9 ˂3 ˂3 IN cord-014516-r59usk02 1499 10 g g NN cord-014516-r59usk02 1499 11 / / SYM cord-014516-r59usk02 1499 12 l l NN cord-014516-r59usk02 1499 13 ) ) -RRB- cord-014516-r59usk02 1499 14 . . . cord-014516-r59usk02 1500 1 A a DT cord-014516-r59usk02 1500 2 positive positive JJ cord-014516-r59usk02 1500 3 correlation correlation NN cord-014516-r59usk02 1500 4 ( ( -LRB- cord-014516-r59usk02 1500 5 r r NN cord-014516-r59usk02 1500 6 = = SYM cord-014516-r59usk02 1500 7 0,60 0,60 CD cord-014516-r59usk02 1500 8 ) ) -RRB- cord-014516-r59usk02 1500 9 was be VBD cord-014516-r59usk02 1500 10 detected detect VBN cord-014516-r59usk02 1500 11 between between IN cord-014516-r59usk02 1500 12 increases increase NNS cord-014516-r59usk02 1500 13 in in IN cord-014516-r59usk02 1500 14 serum serum NN cord-014516-r59usk02 1500 15 concentrations concentration NNS cord-014516-r59usk02 1500 16 of of IN cord-014516-r59usk02 1500 17 SAA SAA NNP cord-014516-r59usk02 1500 18 and and CC cord-014516-r59usk02 1500 19 Hp Hp NNP cord-014516-r59usk02 1500 20 . . . cord-014516-r59usk02 1501 1 The the DT cord-014516-r59usk02 1501 2 increase increase NN cord-014516-r59usk02 1501 3 in in IN cord-014516-r59usk02 1501 4 the the DT cord-014516-r59usk02 1501 5 size size NN cord-014516-r59usk02 1501 6 of of IN cord-014516-r59usk02 1501 7 tumour tumour NN cord-014516-r59usk02 1501 8 was be VBD cord-014516-r59usk02 1501 9 significantly significantly RB cord-014516-r59usk02 1501 10 associated associate VBN cord-014516-r59usk02 1501 11 with with IN cord-014516-r59usk02 1501 12 the the DT cord-014516-r59usk02 1501 13 concentration concentration NN cord-014516-r59usk02 1501 14 of of IN cord-014516-r59usk02 1501 15 SAA SAA NNP cord-014516-r59usk02 1501 16 ( ( -LRB- cord-014516-r59usk02 1501 17 p˂0,05 p˂0,05 NNP cord-014516-r59usk02 1501 18 ) ) -RRB- cord-014516-r59usk02 1501 19 . . . cord-014516-r59usk02 1502 1 Serum serum NN cord-014516-r59usk02 1502 2 Hp Hp NNP cord-014516-r59usk02 1502 3 concentrations concentration NNS cord-014516-r59usk02 1502 4 were be VBD cord-014516-r59usk02 1502 5 significantly significantly RB cord-014516-r59usk02 1502 6 increased increase VBN cord-014516-r59usk02 1502 7 in in IN cord-014516-r59usk02 1502 8 tubulopapillary tubulopapillary JJ cord-014516-r59usk02 1502 9 carcinomas carcinoma NNS cord-014516-r59usk02 1502 10 ( ( -LRB- cord-014516-r59usk02 1502 11 p˂0,05 p˂0,05 NNP cord-014516-r59usk02 1502 12 ) ) -RRB- cord-014516-r59usk02 1502 13 , , , cord-014516-r59usk02 1502 14 and and CC cord-014516-r59usk02 1502 15 IGF-1 IGF-1 NNP cord-014516-r59usk02 1502 16 decreased decrease VBD cord-014516-r59usk02 1502 17 in in IN cord-014516-r59usk02 1502 18 solid solid JJ cord-014516-r59usk02 1502 19 carcinomas carcinoma NNS cord-014516-r59usk02 1502 20 ( ( -LRB- cord-014516-r59usk02 1502 21 p˂0,05 p˂0,05 NNP cord-014516-r59usk02 1502 22 ) ) -RRB- cord-014516-r59usk02 1502 23 . . . cord-014516-r59usk02 1503 1 In in IN cord-014516-r59usk02 1503 2 the the DT cord-014516-r59usk02 1503 3 cats cat NNS cord-014516-r59usk02 1503 4 where where WRB cord-014516-r59usk02 1503 5 serial serial JJ cord-014516-r59usk02 1503 6 determinations determination NNS cord-014516-r59usk02 1503 7 were be VBD cord-014516-r59usk02 1503 8 performed perform VBN cord-014516-r59usk02 1503 9 , , , cord-014516-r59usk02 1503 10 development development NN cord-014516-r59usk02 1503 11 of of IN cord-014516-r59usk02 1503 12 thoracic thoracic JJ cord-014516-r59usk02 1503 13 metastasis metastasis NN cord-014516-r59usk02 1503 14 was be VBD cord-014516-r59usk02 1503 15 significantly significantly RB cord-014516-r59usk02 1503 16 associated associate VBN cord-014516-r59usk02 1503 17 with with IN cord-014516-r59usk02 1503 18 a a DT cord-014516-r59usk02 1503 19 decrease decrease NN cord-014516-r59usk02 1503 20 of of IN cord-014516-r59usk02 1503 21 serum serum NN cord-014516-r59usk02 1503 22 concentration concentration NN cord-014516-r59usk02 1503 23 of of IN cord-014516-r59usk02 1503 24 albumin albumin NN cord-014516-r59usk02 1503 25 ( ( -LRB- cord-014516-r59usk02 1503 26 p˂0,05 p˂0,05 NNP cord-014516-r59usk02 1503 27 ) ) -RRB- cord-014516-r59usk02 1503 28 , , , cord-014516-r59usk02 1503 29 and and CC cord-014516-r59usk02 1503 30 with with IN cord-014516-r59usk02 1503 31 an an DT cord-014516-r59usk02 1503 32 increase increase NN cord-014516-r59usk02 1503 33 of of IN cord-014516-r59usk02 1503 34 SAA SAA NNP cord-014516-r59usk02 1503 35 ( ( -LRB- cord-014516-r59usk02 1503 36 p˂0,05 p˂0,05 NNP cord-014516-r59usk02 1503 37 ) ) -RRB- cord-014516-r59usk02 1503 38 . . . cord-014516-r59usk02 1504 1 This this DT cord-014516-r59usk02 1504 2 study study NN cord-014516-r59usk02 1504 3 suggests suggest VBZ cord-014516-r59usk02 1504 4 that that IN cord-014516-r59usk02 1504 5 feline feline JJ cord-014516-r59usk02 1504 6 mammary mammary JJ cord-014516-r59usk02 1504 7 tumours tumour NNS cord-014516-r59usk02 1504 8 are be VBP cord-014516-r59usk02 1504 9 associated associate VBN cord-014516-r59usk02 1504 10 with with IN cord-014516-r59usk02 1504 11 an an DT cord-014516-r59usk02 1504 12 acute acute JJ cord-014516-r59usk02 1504 13 phase phase NN cord-014516-r59usk02 1504 14 response response NN cord-014516-r59usk02 1504 15 . . . cord-014516-r59usk02 1505 1 According accord VBG cord-014516-r59usk02 1505 2 with with IN cord-014516-r59usk02 1505 3 the the DT cord-014516-r59usk02 1505 4 results result NNS cord-014516-r59usk02 1505 5 obtained obtain VBN cord-014516-r59usk02 1505 6 , , , cord-014516-r59usk02 1505 7 SAA SAA NNP cord-014516-r59usk02 1505 8 , , , cord-014516-r59usk02 1505 9 Hp Hp NNP cord-014516-r59usk02 1505 10 , , , cord-014516-r59usk02 1505 11 albumin albumin NN cord-014516-r59usk02 1505 12 and and CC cord-014516-r59usk02 1505 13 IGF-1 IGF-1 NNP cord-014516-r59usk02 1505 14 might may MD cord-014516-r59usk02 1505 15 be be VB cord-014516-r59usk02 1505 16 important important JJ cord-014516-r59usk02 1505 17 serum serum NN cord-014516-r59usk02 1505 18 biomarkers biomarker NNS cord-014516-r59usk02 1505 19 in in IN cord-014516-r59usk02 1505 20 diagnosis diagnosis NN cord-014516-r59usk02 1505 21 and and CC cord-014516-r59usk02 1505 22 monitoring monitoring NN cord-014516-r59usk02 1505 23 of of IN cord-014516-r59usk02 1505 24 the the DT cord-014516-r59usk02 1505 25 evolution evolution NN cord-014516-r59usk02 1505 26 of of IN cord-014516-r59usk02 1505 27 feline feline JJ cord-014516-r59usk02 1505 28 malignant malignant JJ cord-014516-r59usk02 1505 29 mammary mammary JJ cord-014516-r59usk02 1505 30 neoplasias neoplasias NNP cord-014516-r59usk02 1505 31 . . . cord-014516-r59usk02 1506 1 No no DT cord-014516-r59usk02 1506 2 conflicts conflict NNS cord-014516-r59usk02 1506 3 of of IN cord-014516-r59usk02 1506 4 interest interest NN cord-014516-r59usk02 1506 5 reported report VBN cord-014516-r59usk02 1506 6 . . . cord-014516-r59usk02 1507 1 Histiocytic histiocytic JJ cord-014516-r59usk02 1507 2 sarcoma sarcoma NN cord-014516-r59usk02 1507 3 ( ( -LRB- cord-014516-r59usk02 1507 4 HS HS NNP cord-014516-r59usk02 1507 5 ) ) -RRB- cord-014516-r59usk02 1507 6 is be VBZ cord-014516-r59usk02 1507 7 a a DT cord-014516-r59usk02 1507 8 neoplastic neoplastic JJ cord-014516-r59usk02 1507 9 proliferation proliferation NN cord-014516-r59usk02 1507 10 of of IN cord-014516-r59usk02 1507 11 interstitial interstitial JJ cord-014516-r59usk02 1507 12 dendritic dendritic JJ cord-014516-r59usk02 1507 13 cells cell NNS cord-014516-r59usk02 1507 14 or or CC cord-014516-r59usk02 1507 15 tissue tissue NN cord-014516-r59usk02 1507 16 macrophages macrophage NNS cord-014516-r59usk02 1507 17 . . . cord-014516-r59usk02 1508 1 Dogs dog NNS cord-014516-r59usk02 1508 2 with with IN cord-014516-r59usk02 1508 3 HS HS NNP cord-014516-r59usk02 1508 4 can can MD cord-014516-r59usk02 1508 5 present present VB cord-014516-r59usk02 1508 6 with with IN cord-014516-r59usk02 1508 7 local local JJ cord-014516-r59usk02 1508 8 disease disease NN cord-014516-r59usk02 1508 9 or or CC cord-014516-r59usk02 1508 10 with with IN cord-014516-r59usk02 1508 11 multifocal multifocal JJ cord-014516-r59usk02 1508 12 ( ( -LRB- cord-014516-r59usk02 1508 13 disseminated disseminate VBN cord-014516-r59usk02 1508 14 ) ) -RRB- cord-014516-r59usk02 1508 15 involvement involvement NN cord-014516-r59usk02 1508 16 . . . cord-014516-r59usk02 1509 1 Disseminated disseminate VBN cord-014516-r59usk02 1509 2 HS HS NNP cord-014516-r59usk02 1509 3 is be VBZ cord-014516-r59usk02 1509 4 poorly poorly RB cord-014516-r59usk02 1509 5 responsive responsive JJ cord-014516-r59usk02 1509 6 to to IN cord-014516-r59usk02 1509 7 therapy therapy NN cord-014516-r59usk02 1509 8 and and CC cord-014516-r59usk02 1509 9 almost almost RB cord-014516-r59usk02 1509 10 always always RB cord-014516-r59usk02 1509 11 fatal fatal JJ cord-014516-r59usk02 1509 12 . . . cord-014516-r59usk02 1510 1 Little little JJ cord-014516-r59usk02 1510 2 is be VBZ cord-014516-r59usk02 1510 3 established establish VBN cord-014516-r59usk02 1510 4 regarding regard VBG cord-014516-r59usk02 1510 5 the the DT cord-014516-r59usk02 1510 6 aetio aetio NN cord-014516-r59usk02 1510 7 - - HYPH cord-014516-r59usk02 1510 8 pathology pathology NN cord-014516-r59usk02 1510 9 of of IN cord-014516-r59usk02 1510 10 histiocytic histiocytic JJ cord-014516-r59usk02 1510 11 sarcoma sarcoma NN cord-014516-r59usk02 1510 12 in in IN cord-014516-r59usk02 1510 13 dogs dog NNS cord-014516-r59usk02 1510 14 . . . cord-014516-r59usk02 1511 1 The the DT cord-014516-r59usk02 1511 2 purpose purpose NN cord-014516-r59usk02 1511 3 of of IN cord-014516-r59usk02 1511 4 this this DT cord-014516-r59usk02 1511 5 study study NN cord-014516-r59usk02 1511 6 was be VBD cord-014516-r59usk02 1511 7 to to TO cord-014516-r59usk02 1511 8 establish establish VB cord-014516-r59usk02 1511 9 and and CC cord-014516-r59usk02 1511 10 characterise characterise VB cord-014516-r59usk02 1511 11 a a DT cord-014516-r59usk02 1511 12 HS HS NNP cord-014516-r59usk02 1511 13 cell cell NN cord-014516-r59usk02 1511 14 line line NN cord-014516-r59usk02 1511 15 from from IN cord-014516-r59usk02 1511 16 fresh fresh JJ cord-014516-r59usk02 1511 17 tumour tumour NN cord-014516-r59usk02 1511 18 samples sample NNS cord-014516-r59usk02 1511 19 obtained obtain VBN cord-014516-r59usk02 1511 20 from from IN cord-014516-r59usk02 1511 21 a a DT cord-014516-r59usk02 1511 22 dog dog NN cord-014516-r59usk02 1511 23 with with IN cord-014516-r59usk02 1511 24 disseminated disseminate VBN cord-014516-r59usk02 1511 25 HS HS NNP cord-014516-r59usk02 1511 26 in in IN cord-014516-r59usk02 1511 27 order order NN cord-014516-r59usk02 1511 28 to to TO cord-014516-r59usk02 1511 29 further further RB cord-014516-r59usk02 1511 30 clarify clarify VB cord-014516-r59usk02 1511 31 disease disease NN cord-014516-r59usk02 1511 32 pathogenesis pathogenesis NN cord-014516-r59usk02 1511 33 and and CC cord-014516-r59usk02 1511 34 behaviour behaviour NN cord-014516-r59usk02 1511 35 . . . cord-014516-r59usk02 1512 1 With with IN cord-014516-r59usk02 1512 2 owner owner NN cord-014516-r59usk02 1512 3 consent consent NN cord-014516-r59usk02 1512 4 , , , cord-014516-r59usk02 1512 5 treatment treatment NN cord-014516-r59usk02 1512 6 - - HYPH cord-014516-r59usk02 1512 7 na€ na€ CD cord-014516-r59usk02 1512 8 ıve ıve JJ cord-014516-r59usk02 1512 9 tumour tumour NN cord-014516-r59usk02 1512 10 sections section NNS cord-014516-r59usk02 1512 11 were be VBD cord-014516-r59usk02 1512 12 collected collect VBN cord-014516-r59usk02 1512 13 from from IN cord-014516-r59usk02 1512 14 a a DT cord-014516-r59usk02 1512 15 dog dog NN cord-014516-r59usk02 1512 16 with with IN cord-014516-r59usk02 1512 17 disseminated disseminate VBN cord-014516-r59usk02 1512 18 HS HS NNP cord-014516-r59usk02 1512 19 that that WDT cord-014516-r59usk02 1512 20 was be VBD cord-014516-r59usk02 1512 21 euthanased euthanase VBN cord-014516-r59usk02 1512 22 . . . cord-014516-r59usk02 1513 1 Tumour tumour NN cord-014516-r59usk02 1513 2 tissue tissue NN cord-014516-r59usk02 1513 3 was be VBD cord-014516-r59usk02 1513 4 assessed assess VBN cord-014516-r59usk02 1513 5 with with IN cord-014516-r59usk02 1513 6 immunohistochemistry immunohistochemistry NN cord-014516-r59usk02 1513 7 ( ( -LRB- cord-014516-r59usk02 1513 8 IHC IHC NNP cord-014516-r59usk02 1513 9 ) ) -RRB- cord-014516-r59usk02 1513 10 using use VBG cord-014516-r59usk02 1513 11 antibodies antibody NNS cord-014516-r59usk02 1513 12 against against IN cord-014516-r59usk02 1513 13 canine canine JJ cord-014516-r59usk02 1513 14 CD18 CD18 NNP cord-014516-r59usk02 1513 15 , , , cord-014516-r59usk02 1513 16 CD3 CD3 NNP cord-014516-r59usk02 1513 17 , , , cord-014516-r59usk02 1513 18 and and CC cord-014516-r59usk02 1513 19 PAX-5 PAX-5 NNP cord-014516-r59usk02 1513 20 to to TO cord-014516-r59usk02 1513 21 support support VB cord-014516-r59usk02 1513 22 the the DT cord-014516-r59usk02 1513 23 diagnosis diagnosis NN cord-014516-r59usk02 1513 24 of of IN cord-014516-r59usk02 1513 25 histiocytic histiocytic JJ cord-014516-r59usk02 1513 26 sarcoma sarcoma NN cord-014516-r59usk02 1513 27 . . . cord-014516-r59usk02 1514 1 Primary primary JJ cord-014516-r59usk02 1514 2 cell cell NN cord-014516-r59usk02 1514 3 cultures culture NNS cord-014516-r59usk02 1514 4 ( ( -LRB- cord-014516-r59usk02 1514 5 HSCs HSCs NNP cord-014516-r59usk02 1514 6 ) ) -RRB- cord-014516-r59usk02 1514 7 , , , cord-014516-r59usk02 1514 8 established establish VBN cord-014516-r59usk02 1514 9 from from IN cord-014516-r59usk02 1514 10 the the DT cord-014516-r59usk02 1514 11 tumour tumour NN cord-014516-r59usk02 1514 12 were be VBD cord-014516-r59usk02 1514 13 cultured culture VBN cord-014516-r59usk02 1514 14 and and CC cord-014516-r59usk02 1514 15 maintained maintain VBN cord-014516-r59usk02 1514 16 in in IN cord-014516-r59usk02 1514 17 modified modify VBN cord-014516-r59usk02 1514 18 Eagle Eagle NNP cord-014516-r59usk02 1514 19 's 's POS cord-014516-r59usk02 1514 20 medium medium NN cord-014516-r59usk02 1514 21 with with IN cord-014516-r59usk02 1514 22 10 10 CD cord-014516-r59usk02 1514 23 % % NN cord-014516-r59usk02 1514 24 fetal fetal JJ cord-014516-r59usk02 1514 25 bovine bovine JJ cord-014516-r59usk02 1514 26 serum serum NN cord-014516-r59usk02 1514 27 , , , cord-014516-r59usk02 1514 28 L l NN cord-014516-r59usk02 1514 29 - - HYPH cord-014516-r59usk02 1514 30 glutamine glutamine NN cord-014516-r59usk02 1514 31 , , , cord-014516-r59usk02 1514 32 penicillin penicillin NN cord-014516-r59usk02 1514 33 and and CC cord-014516-r59usk02 1514 34 streptomycin streptomycin NNS cord-014516-r59usk02 1514 35 , , , cord-014516-r59usk02 1514 36 in in IN cord-014516-r59usk02 1514 37 standard standard JJ cord-014516-r59usk02 1514 38 conditions condition NNS cord-014516-r59usk02 1514 39 . . . cord-014516-r59usk02 1515 1 HSCs hsc NNS cord-014516-r59usk02 1515 2 were be VBD cord-014516-r59usk02 1515 3 characterised characterise VBN cord-014516-r59usk02 1515 4 by by IN cord-014516-r59usk02 1515 5 alpha alpha NNP cord-014516-r59usk02 1515 6 naphthyl naphthyl NNP cord-014516-r59usk02 1515 7 acetate acetate NNP cord-014516-r59usk02 1515 8 esterase esterase NNP cord-014516-r59usk02 1515 9 ( ( -LRB- cord-014516-r59usk02 1515 10 ANAE ANAE NNP cord-014516-r59usk02 1515 11 ) ) -RRB- cord-014516-r59usk02 1515 12 and and CC cord-014516-r59usk02 1515 13 lysozyme lysozyme NN cord-014516-r59usk02 1515 14 staining stain VBG cord-014516-r59usk02 1515 15 while while IN cord-014516-r59usk02 1515 16 PCR PCR NNP cord-014516-r59usk02 1515 17 was be VBD cord-014516-r59usk02 1515 18 used use VBN cord-014516-r59usk02 1515 19 to to TO cord-014516-r59usk02 1515 20 detect detect VB cord-014516-r59usk02 1515 21 cell cell NN cord-014516-r59usk02 1515 22 markers marker NNS cord-014516-r59usk02 1515 23 CD1a CD1a NNP cord-014516-r59usk02 1515 24 , , , cord-014516-r59usk02 1515 25 CD11c CD11c NNP cord-014516-r59usk02 1515 26 , , , cord-014516-r59usk02 1515 27 MHC MHC NNP cord-014516-r59usk02 1515 28 II II NNP cord-014516-r59usk02 1515 29 , , , cord-014516-r59usk02 1515 30 CD204 CD204 NNP cord-014516-r59usk02 1515 31 , , , cord-014516-r59usk02 1515 32 CCR2 CCR2 NNP cord-014516-r59usk02 1515 33 , , , cord-014516-r59usk02 1515 34 E e NN cord-014516-r59usk02 1515 35 - - NN cord-014516-r59usk02 1515 36 cadherin cadherin NN cord-014516-r59usk02 1515 37 , , , cord-014516-r59usk02 1515 38 and and CC cord-014516-r59usk02 1515 39 CD4 CD4 NNP cord-014516-r59usk02 1515 40 . . . cord-014516-r59usk02 1516 1 Cell cell NN cord-014516-r59usk02 1516 2 surface surface NN cord-014516-r59usk02 1516 3 markers marker NNS cord-014516-r59usk02 1516 4 were be VBD cord-014516-r59usk02 1516 5 compared compare VBN cord-014516-r59usk02 1516 6 to to IN cord-014516-r59usk02 1516 7 an an DT cord-014516-r59usk02 1516 8 established establish VBN cord-014516-r59usk02 1516 9 canine canine JJ cord-014516-r59usk02 1516 10 HS HS NNP cord-014516-r59usk02 1516 11 cell cell NN cord-014516-r59usk02 1516 12 line line NN cord-014516-r59usk02 1516 13 ( ( -LRB- cord-014516-r59usk02 1516 14 DH82 DH82 NNP cord-014516-r59usk02 1516 15 ) ) -RRB- cord-014516-r59usk02 1516 16 . . . cord-014516-r59usk02 1517 1 Phagocytic phagocytic JJ cord-014516-r59usk02 1517 2 activity activity NN cord-014516-r59usk02 1517 3 of of IN cord-014516-r59usk02 1517 4 HSC HSC NNP cord-014516-r59usk02 1517 5 cells cell NNS cord-014516-r59usk02 1517 6 was be VBD cord-014516-r59usk02 1517 7 assessed assess VBN cord-014516-r59usk02 1517 8 using use VBG cord-014516-r59usk02 1517 9 cellular cellular JJ cord-014516-r59usk02 1517 10 uptake uptake NN cord-014516-r59usk02 1517 11 of of IN cord-014516-r59usk02 1517 12 carboxylated carboxylated JJ cord-014516-r59usk02 1517 13 fluorescent fluorescent JJ cord-014516-r59usk02 1517 14 beads bead NNS cord-014516-r59usk02 1517 15 and and CC cord-014516-r59usk02 1517 16 documented document VBN cord-014516-r59usk02 1517 17 using use VBG cord-014516-r59usk02 1517 18 flow flow NN cord-014516-r59usk02 1517 19 cytometry cytometry NN cord-014516-r59usk02 1517 20 and and CC cord-014516-r59usk02 1517 21 fluorescent fluorescent NN cord-014516-r59usk02 1517 22 microscopy microscopy NNS cord-014516-r59usk02 1517 23 . . . cord-014516-r59usk02 1518 1 Tumour tumour NN cord-014516-r59usk02 1518 2 tissue tissue NN cord-014516-r59usk02 1518 3 was be VBD cord-014516-r59usk02 1518 4 strongly strongly RB cord-014516-r59usk02 1518 5 CD18 CD18 NNP cord-014516-r59usk02 1518 6 positive positive JJ cord-014516-r59usk02 1518 7 and and CC cord-014516-r59usk02 1518 8 negative negative JJ cord-014516-r59usk02 1518 9 for for IN cord-014516-r59usk02 1518 10 CD3 CD3 NNP cord-014516-r59usk02 1518 11 and and CC cord-014516-r59usk02 1518 12 PAX-5 PAX-5 NNP cord-014516-r59usk02 1518 13 . . . cord-014516-r59usk02 1519 1 Cultured cultured JJ cord-014516-r59usk02 1519 2 cells cell NNS cord-014516-r59usk02 1519 3 exhibited exhibit VBD cord-014516-r59usk02 1519 4 morphological morphological JJ cord-014516-r59usk02 1519 5 characteristics characteristic NNS cord-014516-r59usk02 1519 6 consist consist VBP cord-014516-r59usk02 1519 7 with with IN cord-014516-r59usk02 1519 8 dendritic dendritic JJ cord-014516-r59usk02 1519 9 cells cell NNS cord-014516-r59usk02 1519 10 , , , cord-014516-r59usk02 1519 11 such such JJ cord-014516-r59usk02 1519 12 as as IN cord-014516-r59usk02 1519 13 projections projection NNS cord-014516-r59usk02 1519 14 and and CC cord-014516-r59usk02 1519 15 pleomorphism pleomorphism NN cord-014516-r59usk02 1519 16 . . . cord-014516-r59usk02 1520 1 HSC HSC NNP cord-014516-r59usk02 1520 2 cells cell NNS cord-014516-r59usk02 1520 3 stained stain VBN cord-014516-r59usk02 1520 4 positively positively RB cord-014516-r59usk02 1520 5 for for IN cord-014516-r59usk02 1520 6 non non JJ cord-014516-r59usk02 1520 7 - - JJ cord-014516-r59usk02 1520 8 specific specific JJ cord-014516-r59usk02 1520 9 esterase esterase NN cord-014516-r59usk02 1520 10 ( ( -LRB- cord-014516-r59usk02 1520 11 ANAE ANAE NNP cord-014516-r59usk02 1520 12 ) ) -RRB- cord-014516-r59usk02 1520 13 and and CC cord-014516-r59usk02 1520 14 lysozyme lysozyme NNS cord-014516-r59usk02 1520 15 , , , cord-014516-r59usk02 1520 16 and and CC cord-014516-r59usk02 1520 17 PCR PCR NNP cord-014516-r59usk02 1520 18 indicated indicate VBD cord-014516-r59usk02 1520 19 cells cell NNS cord-014516-r59usk02 1520 20 were be VBD cord-014516-r59usk02 1520 21 positive positive JJ cord-014516-r59usk02 1520 22 for for IN cord-014516-r59usk02 1520 23 CD1a CD1a NNP cord-014516-r59usk02 1520 24 , , , cord-014516-r59usk02 1520 25 CD11c CD11c NNP cord-014516-r59usk02 1520 26 , , , cord-014516-r59usk02 1520 27 MHC MHC NNP cord-014516-r59usk02 1520 28 II II NNP cord-014516-r59usk02 1520 29 and and CC cord-014516-r59usk02 1520 30 CD204 CD204 NNP cord-014516-r59usk02 1520 31 and and CC cord-014516-r59usk02 1520 32 negative negative JJ cord-014516-r59usk02 1520 33 for for IN cord-014516-r59usk02 1520 34 CD90 CD90 NNP cord-014516-r59usk02 1520 35 and and CC cord-014516-r59usk02 1520 36 E e NN cord-014516-r59usk02 1520 37 - - NN cord-014516-r59usk02 1520 38 cadherin cadherin NN cord-014516-r59usk02 1520 39 . . . cord-014516-r59usk02 1521 1 HSC HSC NNP cord-014516-r59usk02 1521 2 cells cell NNS cord-014516-r59usk02 1521 3 were be VBD cord-014516-r59usk02 1521 4 positive positive JJ cord-014516-r59usk02 1521 5 for for IN cord-014516-r59usk02 1521 6 MHC MHC NNP cord-014516-r59usk02 1521 7 II II NNP cord-014516-r59usk02 1521 8 and and CC cord-014516-r59usk02 1521 9 CCR2 CCR2 NNP cord-014516-r59usk02 1521 10 while while IN cord-014516-r59usk02 1521 11 DH82 DH82 NNP cord-014516-r59usk02 1521 12 cells cell NNS cord-014516-r59usk02 1521 13 were be VBD cord-014516-r59usk02 1521 14 negative negative JJ cord-014516-r59usk02 1521 15 . . . cord-014516-r59usk02 1522 1 Phagocytic phagocytic JJ cord-014516-r59usk02 1522 2 activity activity NN cord-014516-r59usk02 1522 3 was be VBD cord-014516-r59usk02 1522 4 evident evident JJ cord-014516-r59usk02 1522 5 . . . cord-014516-r59usk02 1523 1 A a DT cord-014516-r59usk02 1523 2 novel novel JJ cord-014516-r59usk02 1523 3 HS HS NNP cord-014516-r59usk02 1523 4 cell cell NN cord-014516-r59usk02 1523 5 line line NN cord-014516-r59usk02 1523 6 ( ( -LRB- cord-014516-r59usk02 1523 7 HSC HSC NNP cord-014516-r59usk02 1523 8 ) ) -RRB- cord-014516-r59usk02 1523 9 was be VBD cord-014516-r59usk02 1523 10 established establish VBN cord-014516-r59usk02 1523 11 and and CC cord-014516-r59usk02 1523 12 characterized characterize VBN cord-014516-r59usk02 1523 13 from from IN cord-014516-r59usk02 1523 14 primary primary JJ cord-014516-r59usk02 1523 15 tumour tumour NN cord-014516-r59usk02 1523 16 tissue tissue NN cord-014516-r59usk02 1523 17 collected collect VBN cord-014516-r59usk02 1523 18 from from IN cord-014516-r59usk02 1523 19 a a DT cord-014516-r59usk02 1523 20 dog dog NN cord-014516-r59usk02 1523 21 with with IN cord-014516-r59usk02 1523 22 disseminated disseminate VBN cord-014516-r59usk02 1523 23 disease disease NN cord-014516-r59usk02 1523 24 . . . cord-014516-r59usk02 1524 1 HSC HSC NNP cord-014516-r59usk02 1524 2 cells cell NNS cord-014516-r59usk02 1524 3 were be VBD cord-014516-r59usk02 1524 4 most most RBS cord-014516-r59usk02 1524 5 consistent consistent JJ cord-014516-r59usk02 1524 6 with with IN cord-014516-r59usk02 1524 7 interstitial interstitial JJ cord-014516-r59usk02 1524 8 dendritic dendritic JJ cord-014516-r59usk02 1524 9 cell cell NN cord-014516-r59usk02 1524 10 origin origin NN cord-014516-r59usk02 1524 11 based base VBN cord-014516-r59usk02 1524 12 on on IN cord-014516-r59usk02 1524 13 CD1a CD1a NNP cord-014516-r59usk02 1524 14 , , , cord-014516-r59usk02 1524 15 CD11c CD11c NNP cord-014516-r59usk02 1524 16 , , , cord-014516-r59usk02 1524 17 and and CC cord-014516-r59usk02 1524 18 MHC MHC NNP cord-014516-r59usk02 1524 19 II II NNP cord-014516-r59usk02 1524 20 staining stain VBG cord-014516-r59usk02 1524 21 as as RB cord-014516-r59usk02 1524 22 well well RB cord-014516-r59usk02 1524 23 as as IN cord-014516-r59usk02 1524 24 demonstrable demonstrable JJ cord-014516-r59usk02 1524 25 phagocytic phagocytic JJ cord-014516-r59usk02 1524 26 activity activity NN cord-014516-r59usk02 1524 27 . . . cord-014516-r59usk02 1525 1 HSC HSC NNP cord-014516-r59usk02 1525 2 cells cell NNS cord-014516-r59usk02 1525 3 also also RB cord-014516-r59usk02 1525 4 displayed display VBD cord-014516-r59usk02 1525 5 expression expression NN cord-014516-r59usk02 1525 6 of of IN cord-014516-r59usk02 1525 7 CCR2 CCR2 NNP cord-014516-r59usk02 1525 8 , , , cord-014516-r59usk02 1525 9 unlike unlike IN cord-014516-r59usk02 1525 10 the the DT cord-014516-r59usk02 1525 11 established establish VBN cord-014516-r59usk02 1525 12 DH82 DH82 NNP cord-014516-r59usk02 1525 13 line line NN cord-014516-r59usk02 1525 14 , , , cord-014516-r59usk02 1525 15 supporting support VBG cord-014516-r59usk02 1525 16 a a DT cord-014516-r59usk02 1525 17 notion notion NN cord-014516-r59usk02 1525 18 that that IN cord-014516-r59usk02 1525 19 HS HS NNP cord-014516-r59usk02 1525 20 consists consist VBZ cord-014516-r59usk02 1525 21 of of IN cord-014516-r59usk02 1525 22 a a DT cord-014516-r59usk02 1525 23 variety variety NN cord-014516-r59usk02 1525 24 of of IN cord-014516-r59usk02 1525 25 subtypes subtype NNS cord-014516-r59usk02 1525 26 . . . cord-014516-r59usk02 1526 1 CCR2 CCR2 NNP cord-014516-r59usk02 1526 2 has have VBZ cord-014516-r59usk02 1526 3 been be VBN cord-014516-r59usk02 1526 4 linked link VBN cord-014516-r59usk02 1526 5 to to IN cord-014516-r59usk02 1526 6 HS HS NNP cord-014516-r59usk02 1526 7 growth growth NN cord-014516-r59usk02 1526 8 and and CC cord-014516-r59usk02 1526 9 metastasis metastasis NN cord-014516-r59usk02 1526 10 , , , cord-014516-r59usk02 1526 11 suggesting suggest VBG cord-014516-r59usk02 1526 12 it -PRON- PRP cord-014516-r59usk02 1526 13 may may MD cord-014516-r59usk02 1526 14 represent represent VB cord-014516-r59usk02 1526 15 a a DT cord-014516-r59usk02 1526 16 possible possible JJ cord-014516-r59usk02 1526 17 therapeutic therapeutic JJ cord-014516-r59usk02 1526 18 target target NN cord-014516-r59usk02 1526 19 . . . cord-014516-r59usk02 1527 1 Further further JJ cord-014516-r59usk02 1527 2 studies study NNS cord-014516-r59usk02 1527 3 establishing establish VBG cord-014516-r59usk02 1527 4 and and CC cord-014516-r59usk02 1527 5 characterising characterise VBG cord-014516-r59usk02 1527 6 canine canine JJ cord-014516-r59usk02 1527 7 HS HS NNP cord-014516-r59usk02 1527 8 cells cell NNS cord-014516-r59usk02 1527 9 may may MD cord-014516-r59usk02 1527 10 contribute contribute VB cord-014516-r59usk02 1527 11 to to IN cord-014516-r59usk02 1527 12 the the DT cord-014516-r59usk02 1527 13 elucidation elucidation NN cord-014516-r59usk02 1527 14 of of IN cord-014516-r59usk02 1527 15 mechanisms mechanism NNS cord-014516-r59usk02 1527 16 of of IN cord-014516-r59usk02 1527 17 tumourigenesis tumourigenesis NN cord-014516-r59usk02 1527 18 . . . cord-014516-r59usk02 1528 1 No no DT cord-014516-r59usk02 1528 2 conflicts conflict NNS cord-014516-r59usk02 1528 3 of of IN cord-014516-r59usk02 1528 4 interest interest NN cord-014516-r59usk02 1528 5 reported report VBN cord-014516-r59usk02 1528 6 . . . cord-014516-r59usk02 1529 1 Virulent virulent JJ cord-014516-r59usk02 1529 2 - - HYPH cord-014516-r59usk02 1529 3 systemic systemic JJ cord-014516-r59usk02 1529 4 ( ( -LRB- cord-014516-r59usk02 1529 5 VS)-FCV vs)-fcv NN cord-014516-r59usk02 1529 6 that that DT cord-014516-r59usk02 1529 7 induce induce VBP cord-014516-r59usk02 1529 8 cutaneous cutaneous JJ cord-014516-r59usk02 1529 9 edema edema NN cord-014516-r59usk02 1529 10 , , , cord-014516-r59usk02 1529 11 ulcerations ulceration NNS cord-014516-r59usk02 1529 12 of of IN cord-014516-r59usk02 1529 13 the the DT cord-014516-r59usk02 1529 14 head head NN cord-014516-r59usk02 1529 15 and and CC cord-014516-r59usk02 1529 16 feet foot NNS cord-014516-r59usk02 1529 17 , , , cord-014516-r59usk02 1529 18 and and CC cord-014516-r59usk02 1529 19 occasionally occasionally RB cord-014516-r59usk02 1529 20 jaundice jaundice NN cord-014516-r59usk02 1529 21 have have VBP cord-014516-r59usk02 1529 22 been be VBN cord-014516-r59usk02 1529 23 described describe VBN cord-014516-r59usk02 1529 24 in in IN cord-014516-r59usk02 1529 25 the the DT cord-014516-r59usk02 1529 26 USA USA NNP cord-014516-r59usk02 1529 27 and and CC cord-014516-r59usk02 1529 28 Europe Europe NNP cord-014516-r59usk02 1529 29 . . . cord-014516-r59usk02 1530 1 Here here RB cord-014516-r59usk02 1530 2 we -PRON- PRP cord-014516-r59usk02 1530 3 characterize characterize VBP cord-014516-r59usk02 1530 4 for for IN cord-014516-r59usk02 1530 5 the the DT cord-014516-r59usk02 1530 6 first first JJ cord-014516-r59usk02 1530 7 time time NN cord-014516-r59usk02 1530 8 VS VS NNP cord-014516-r59usk02 1530 9 - - HYPH cord-014516-r59usk02 1530 10 FCV FCV NNP cord-014516-r59usk02 1530 11 outbreaks outbreak NNS cord-014516-r59usk02 1530 12 in in IN cord-014516-r59usk02 1530 13 cats cat NNS cord-014516-r59usk02 1530 14 in in IN cord-014516-r59usk02 1530 15 Switzerland Switzerland NNP cord-014516-r59usk02 1530 16 and and CC cord-014516-r59usk02 1530 17 Liechtenstein Liechtenstein NNP cord-014516-r59usk02 1530 18 . . . cord-014516-r59usk02 1531 1 The the DT cord-014516-r59usk02 1531 2 four four CD cord-014516-r59usk02 1531 3 outbreaks outbreak NNS cord-014516-r59usk02 1531 4 occurred occur VBD cord-014516-r59usk02 1531 5 in in IN cord-014516-r59usk02 1531 6 three three CD cord-014516-r59usk02 1531 7 geographically geographically RB cord-014516-r59usk02 1531 8 separated separated JJ cord-014516-r59usk02 1531 9 locations location NNS cord-014516-r59usk02 1531 10 : : : cord-014516-r59usk02 1531 11 Schaan Schaan NNP cord-014516-r59usk02 1531 12 ( ( -LRB- cord-014516-r59usk02 1531 13 Liechtenstein Liechtenstein NNP cord-014516-r59usk02 1531 14 , , , cord-014516-r59usk02 1531 15 shelter shelter NN cord-014516-r59usk02 1531 16 1 1 CD cord-014516-r59usk02 1531 17 ) ) -RRB- cord-014516-r59usk02 1531 18 , , , cord-014516-r59usk02 1531 19 Zurich Zurich NNP cord-014516-r59usk02 1531 20 ( ( -LRB- cord-014516-r59usk02 1531 21 Switzerland Switzerland NNP cord-014516-r59usk02 1531 22 ) ) -RRB- cord-014516-r59usk02 1531 23 and and CC cord-014516-r59usk02 1531 24 Lausanne Lausanne NNP cord-014516-r59usk02 1531 25 ( ( -LRB- cord-014516-r59usk02 1531 26 Switzerland Switzerland NNP cord-014516-r59usk02 1531 27 , , , cord-014516-r59usk02 1531 28 shelter shelter NN cord-014516-r59usk02 1531 29 2 2 CD cord-014516-r59usk02 1531 30 ) ) -RRB- cord-014516-r59usk02 1531 31 between between IN cord-014516-r59usk02 1531 32 November November NNP cord-014516-r59usk02 1531 33 2011 2011 CD cord-014516-r59usk02 1531 34 and and CC cord-014516-r59usk02 1531 35 January January NNP cord-014516-r59usk02 1531 36 2013 2013 CD cord-014516-r59usk02 1531 37 . . . cord-014516-r59usk02 1532 1 PCR PCR NNP cord-014516-r59usk02 1532 2 ( ( -LRB- cord-014516-r59usk02 1532 3 FCV FCV NNP cord-014516-r59usk02 1532 4 and and CC cord-014516-r59usk02 1532 5 Feline Feline NNP cord-014516-r59usk02 1532 6 herpesvirus-1 herpesvirus-1 NNP cord-014516-r59usk02 1532 7 , , , cord-014516-r59usk02 1532 8 FHV-1 FHV-1 NNP cord-014516-r59usk02 1532 9 ) ) -RRB- cord-014516-r59usk02 1532 10 , , , cord-014516-r59usk02 1532 11 virus virus NN cord-014516-r59usk02 1532 12 isolation isolation NN cord-014516-r59usk02 1532 13 and and CC cord-014516-r59usk02 1532 14 FeLV FeLV NNP cord-014516-r59usk02 1532 15 / / SYM cord-014516-r59usk02 1532 16 FIV FIV NNP cord-014516-r59usk02 1532 17 testing testing NN cord-014516-r59usk02 1532 18 were be VBD cord-014516-r59usk02 1532 19 performed perform VBN cord-014516-r59usk02 1532 20 on on IN cord-014516-r59usk02 1532 21 saliva saliva NN cord-014516-r59usk02 1532 22 and and CC cord-014516-r59usk02 1532 23 blood blood NN cord-014516-r59usk02 1532 24 samples sample NNS cord-014516-r59usk02 1532 25 collected collect VBN cord-014516-r59usk02 1532 26 from from IN cord-014516-r59usk02 1532 27 clinically clinically RB cord-014516-r59usk02 1532 28 affected affected JJ cord-014516-r59usk02 1532 29 cats cat NNS cord-014516-r59usk02 1532 30 . . . cord-014516-r59usk02 1533 1 Furthermore furthermore RB cord-014516-r59usk02 1533 2 , , , cord-014516-r59usk02 1533 3 saliva saliva NN cord-014516-r59usk02 1533 4 for for IN cord-014516-r59usk02 1533 5 PCR PCR NNP cord-014516-r59usk02 1533 6 was be VBD cord-014516-r59usk02 1533 7 collected collect VBN cord-014516-r59usk02 1533 8 from from IN cord-014516-r59usk02 1533 9 31 31 CD cord-014516-r59usk02 1533 10 additional additional JJ cord-014516-r59usk02 1533 11 cats cat NNS cord-014516-r59usk02 1533 12 in in IN cord-014516-r59usk02 1533 13 shelter shelter NN cord-014516-r59usk02 1533 14 1 1 CD cord-014516-r59usk02 1533 15 . . . cord-014516-r59usk02 1534 1 Phylogenetic phylogenetic JJ cord-014516-r59usk02 1534 2 analyses analysis NNS cord-014516-r59usk02 1534 3 were be VBD cord-014516-r59usk02 1534 4 performed perform VBN cord-014516-r59usk02 1534 5 based base VBN cord-014516-r59usk02 1534 6 on on IN cord-014516-r59usk02 1534 7 the the DT cord-014516-r59usk02 1534 8 capsid capsid NN cord-014516-r59usk02 1534 9 ( ( -LRB- cord-014516-r59usk02 1534 10 VP1 VP1 NNP cord-014516-r59usk02 1534 11 ) ) -RRB- cord-014516-r59usk02 1534 12 gene gene NN cord-014516-r59usk02 1534 13 sequence sequence NN cord-014516-r59usk02 1534 14 of of IN cord-014516-r59usk02 1534 15 FCV FCV NNP cord-014516-r59usk02 1534 16 . . . cord-014516-r59usk02 1535 1 VS VS NNP cord-014516-r59usk02 1535 2 - - HYPH cord-014516-r59usk02 1535 3 FCV FCV NNP cord-014516-r59usk02 1535 4 isolates isolate NNS cord-014516-r59usk02 1535 5 were be VBD cord-014516-r59usk02 1535 6 tested test VBN cord-014516-r59usk02 1535 7 for for IN cord-014516-r59usk02 1535 8 virus virus NN cord-014516-r59usk02 1535 9 neutralization neutralization NN cord-014516-r59usk02 1535 10 with with IN cord-014516-r59usk02 1535 11 sera sera NNP cord-014516-r59usk02 1535 12 raised raise VBD cord-014516-r59usk02 1535 13 against against IN cord-014516-r59usk02 1535 14 common common JJ cord-014516-r59usk02 1535 15 FCV FCV NNP cord-014516-r59usk02 1535 16 vaccine vaccine NN cord-014516-r59usk02 1535 17 strains strain NNS cord-014516-r59usk02 1535 18 . . . cord-014516-r59usk02 1536 1 Outbreak outbreak NN cord-014516-r59usk02 1536 2 1 1 CD cord-014516-r59usk02 1536 3 occurred occur VBD cord-014516-r59usk02 1536 4 in in IN cord-014516-r59usk02 1536 5 a a DT cord-014516-r59usk02 1536 6 cattery cattery NN cord-014516-r59usk02 1536 7 in in IN cord-014516-r59usk02 1536 8 Liechtenstein Liechtenstein NNP cord-014516-r59usk02 1536 9 and and CC cord-014516-r59usk02 1536 10 involved involve VBD cord-014516-r59usk02 1536 11 five five CD cord-014516-r59usk02 1536 12 non non JJ cord-014516-r59usk02 1536 13 - - JJ cord-014516-r59usk02 1536 14 vaccinated vaccinated JJ cord-014516-r59usk02 1536 15 , , , cord-014516-r59usk02 1536 16 3-months 3-months CD cord-014516-r59usk02 1536 17 old old JJ cord-014516-r59usk02 1536 18 siblings sibling NNS cord-014516-r59usk02 1536 19 with with IN cord-014516-r59usk02 1536 20 fever fever NN cord-014516-r59usk02 1536 21 , , , cord-014516-r59usk02 1536 22 edema edema NN cord-014516-r59usk02 1536 23 , , , cord-014516-r59usk02 1536 24 skin skin NN cord-014516-r59usk02 1536 25 and and CC cord-014516-r59usk02 1536 26 tongue tongue NN cord-014516-r59usk02 1536 27 ulcerations ulceration NNS cord-014516-r59usk02 1536 28 . . . cord-014516-r59usk02 1537 1 Outbreak outbreak NN cord-014516-r59usk02 1537 2 2 2 CD cord-014516-r59usk02 1537 3 occurred occur VBD cord-014516-r59usk02 1537 4 in in IN cord-014516-r59usk02 1537 5 a a DT cord-014516-r59usk02 1537 6 small small JJ cord-014516-r59usk02 1537 7 animal animal NN cord-014516-r59usk02 1537 8 clinic clinic NN cord-014516-r59usk02 1537 9 in in IN cord-014516-r59usk02 1537 10 Zurich Zurich NNP cord-014516-r59usk02 1537 11 . . . cord-014516-r59usk02 1538 1 A a DT cord-014516-r59usk02 1538 2 10-year 10-year CD cord-014516-r59usk02 1538 3 old old JJ cord-014516-r59usk02 1538 4 cat cat NN cord-014516-r59usk02 1538 5 presented present VBN cord-014516-r59usk02 1538 6 with with IN cord-014516-r59usk02 1538 7 severe severe JJ cord-014516-r59usk02 1538 8 paw paw NN cord-014516-r59usk02 1538 9 edema edema NN cord-014516-r59usk02 1538 10 , , , cord-014516-r59usk02 1538 11 fever fever NN cord-014516-r59usk02 1538 12 , , , cord-014516-r59usk02 1538 13 tongue tongue NN cord-014516-r59usk02 1538 14 and and CC cord-014516-r59usk02 1538 15 skin skin NN cord-014516-r59usk02 1538 16 ulcerations ulceration NNS cord-014516-r59usk02 1538 17 , , , cord-014516-r59usk02 1538 18 progressive progressive JJ cord-014516-r59usk02 1538 19 hypoproteinemia hypoproteinemia NN cord-014516-r59usk02 1538 20 and and CC cord-014516-r59usk02 1538 21 hyperbilirubinemia hyperbilirubinemia NNP cord-014516-r59usk02 1538 22 . . . cord-014516-r59usk02 1539 1 Outbreaks outbreak NNS cord-014516-r59usk02 1539 2 3 3 CD cord-014516-r59usk02 1539 3 and and CC cord-014516-r59usk02 1539 4 4 4 CD cord-014516-r59usk02 1539 5 happened happen VBD cord-014516-r59usk02 1539 6 in in IN cord-014516-r59usk02 1539 7 a a DT cord-014516-r59usk02 1539 8 cattery cattery NN cord-014516-r59usk02 1539 9 in in IN cord-014516-r59usk02 1539 10 Lausanne Lausanne NNP cord-014516-r59usk02 1539 11 five five CD cord-014516-r59usk02 1539 12 months month NNS cord-014516-r59usk02 1539 13 apart apart RB cord-014516-r59usk02 1539 14 and and CC cord-014516-r59usk02 1539 15 involved involve VBD cord-014516-r59usk02 1539 16 two two CD cord-014516-r59usk02 1539 17 litters litter NNS cord-014516-r59usk02 1539 18 of of IN cord-014516-r59usk02 1539 19 non non JJ cord-014516-r59usk02 1539 20 - - JJ cord-014516-r59usk02 1539 21 vaccinated vaccinated JJ cord-014516-r59usk02 1539 22 , , , cord-014516-r59usk02 1539 23 2-to 2-to CD cord-014516-r59usk02 1539 24 3-months 3-months CD cord-014516-r59usk02 1539 25 old old JJ cord-014516-r59usk02 1539 26 kittens kitten NNS cord-014516-r59usk02 1539 27 . . . cord-014516-r59usk02 1540 1 The the DT cord-014516-r59usk02 1540 2 cats cat NNS cord-014516-r59usk02 1540 3 presented present VBN cord-014516-r59usk02 1540 4 with with IN cord-014516-r59usk02 1540 5 fever fever NN cord-014516-r59usk02 1540 6 , , , cord-014516-r59usk02 1540 7 nasal nasal NN cord-014516-r59usk02 1540 8 discharge discharge NN cord-014516-r59usk02 1540 9 , , , cord-014516-r59usk02 1540 10 edema edema NN cord-014516-r59usk02 1540 11 and and CC cord-014516-r59usk02 1540 12 skin skin NN cord-014516-r59usk02 1540 13 and and CC cord-014516-r59usk02 1540 14 oral oral JJ cord-014516-r59usk02 1540 15 ulcerations ulceration NNS cord-014516-r59usk02 1540 16 . . . cord-014516-r59usk02 1541 1 All all DT cord-014516-r59usk02 1541 2 affected affect VBN cord-014516-r59usk02 1541 3 cats cat NNS cord-014516-r59usk02 1541 4 tested test VBD cord-014516-r59usk02 1541 5 FCV FCV NNP cord-014516-r59usk02 1541 6 - - HYPH cord-014516-r59usk02 1541 7 positive positive JJ cord-014516-r59usk02 1541 8 but but CC cord-014516-r59usk02 1541 9 negative negative JJ cord-014516-r59usk02 1541 10 for for IN cord-014516-r59usk02 1541 11 FHV-1 FHV-1 NNP cord-014516-r59usk02 1541 12 , , , cord-014516-r59usk02 1541 13 FeLV FeLV NNP cord-014516-r59usk02 1541 14 and and CC cord-014516-r59usk02 1541 15 FIV FIV NNP cord-014516-r59usk02 1541 16 , , , cord-014516-r59usk02 1541 17 except except IN cord-014516-r59usk02 1541 18 for for IN cord-014516-r59usk02 1541 19 one one CD cord-014516-r59usk02 1541 20 kitten kitten NN cord-014516-r59usk02 1541 21 from from IN cord-014516-r59usk02 1541 22 outbreak outbreak NN cord-014516-r59usk02 1541 23 4 4 CD cord-014516-r59usk02 1541 24 ( ( -LRB- cord-014516-r59usk02 1541 25 FIV fiv NN cord-014516-r59usk02 1541 26 - - HYPH cord-014516-r59usk02 1541 27 positive positive JJ cord-014516-r59usk02 1541 28 ) ) -RRB- cord-014516-r59usk02 1541 29 . . . cord-014516-r59usk02 1542 1 All all DT cord-014516-r59usk02 1542 2 cats cat NNS cord-014516-r59usk02 1542 3 in in IN cord-014516-r59usk02 1542 4 outbreaks outbreak NNS cord-014516-r59usk02 1542 5 1 1 CD cord-014516-r59usk02 1542 6 and and CC cord-014516-r59usk02 1542 7 3 3 CD cord-014516-r59usk02 1542 8 recovered recover VBD cord-014516-r59usk02 1542 9 , , , cord-014516-r59usk02 1542 10 whereas whereas IN cord-014516-r59usk02 1542 11 all all DT cord-014516-r59usk02 1542 12 cats cat NNS cord-014516-r59usk02 1542 13 in in IN cord-014516-r59usk02 1542 14 outbreaks outbreak NNS cord-014516-r59usk02 1542 15 2 2 CD cord-014516-r59usk02 1542 16 and and CC cord-014516-r59usk02 1542 17 4 4 CD cord-014516-r59usk02 1542 18 died die VBD cord-014516-r59usk02 1542 19 or or CC cord-014516-r59usk02 1542 20 were be VBD cord-014516-r59usk02 1542 21 euthanized euthanize VBN cord-014516-r59usk02 1542 22 because because IN cord-014516-r59usk02 1542 23 of of IN cord-014516-r59usk02 1542 24 clinical clinical JJ cord-014516-r59usk02 1542 25 deterioration deterioration NN cord-014516-r59usk02 1542 26 . . . cord-014516-r59usk02 1543 1 Each each DT cord-014516-r59usk02 1543 2 outbreak outbreak NN cord-014516-r59usk02 1543 3 was be VBD cord-014516-r59usk02 1543 4 caused cause VBN cord-014516-r59usk02 1543 5 by by IN cord-014516-r59usk02 1543 6 a a DT cord-014516-r59usk02 1543 7 phylogenetically phylogenetically RB cord-014516-r59usk02 1543 8 distinct distinct JJ cord-014516-r59usk02 1543 9 VS VS NNP cord-014516-r59usk02 1543 10 - - HYPH cord-014516-r59usk02 1543 11 FCV FCV NNP cord-014516-r59usk02 1543 12 strain strain NN cord-014516-r59usk02 1543 13 . . . cord-014516-r59usk02 1544 1 In in IN cord-014516-r59usk02 1544 2 shelter shelter NN cord-014516-r59usk02 1544 3 1 1 CD cord-014516-r59usk02 1544 4 , , , cord-014516-r59usk02 1544 5 the the DT cord-014516-r59usk02 1544 6 queen queen NN cord-014516-r59usk02 1544 7 and and CC cord-014516-r59usk02 1544 8 three three CD cord-014516-r59usk02 1544 9 in in IN cord-014516-r59usk02 1544 10 contact contact NN cord-014516-r59usk02 1544 11 cats cat NNS cord-014516-r59usk02 1544 12 remained remain VBD cord-014516-r59usk02 1544 13 asymptomatic asymptomatic JJ cord-014516-r59usk02 1544 14 although although IN cord-014516-r59usk02 1544 15 infected infect VBN cord-014516-r59usk02 1544 16 with with IN cord-014516-r59usk02 1544 17 the the DT cord-014516-r59usk02 1544 18 same same JJ cord-014516-r59usk02 1544 19 VS VS NNP cord-014516-r59usk02 1544 20 - - HYPH cord-014516-r59usk02 1544 21 FCV FCV NNP cord-014516-r59usk02 1544 22 strain strain NN cord-014516-r59usk02 1544 23 . . . cord-014516-r59usk02 1545 1 Furthermore furthermore RB cord-014516-r59usk02 1545 2 , , , cord-014516-r59usk02 1545 3 7/27 7/27 CD cord-014516-r59usk02 1545 4 other other JJ cord-014516-r59usk02 1545 5 cats cat NNS cord-014516-r59usk02 1545 6 of of IN cord-014516-r59usk02 1545 7 shelter shelter NN cord-014516-r59usk02 1545 8 1 1 CD cord-014516-r59usk02 1545 9 were be VBD cord-014516-r59usk02 1545 10 infected infect VBN cord-014516-r59usk02 1545 11 with with IN cord-014516-r59usk02 1545 12 closely closely RB cord-014516-r59usk02 1545 13 related relate VBN cord-014516-r59usk02 1545 14 , , , cord-014516-r59usk02 1545 15 but but CC cord-014516-r59usk02 1545 16 distinct distinct JJ cord-014516-r59usk02 1545 17 FCV FCV NNP cord-014516-r59usk02 1545 18 strains strain NNS cord-014516-r59usk02 1545 19 . . . cord-014516-r59usk02 1546 1 The the DT cord-014516-r59usk02 1546 2 VS VS NNP cord-014516-r59usk02 1546 3 - - HYPH cord-014516-r59usk02 1546 4 FCV FCV NNP cord-014516-r59usk02 1546 5 isolates isolate VBZ cord-014516-r59usk02 1546 6 from from IN cord-014516-r59usk02 1546 7 the the DT cord-014516-r59usk02 1546 8 two two CD cord-014516-r59usk02 1546 9 outbreaks outbreak NNS cord-014516-r59usk02 1546 10 in in IN cord-014516-r59usk02 1546 11 shelter shelter NN cord-014516-r59usk02 1546 12 2 2 CD cord-014516-r59usk02 1546 13 were be VBD cord-014516-r59usk02 1546 14 distinct distinct JJ cord-014516-r59usk02 1546 15 but but CC cord-014516-r59usk02 1546 16 phylogenetically phylogenetically RB cord-014516-r59usk02 1546 17 related related JJ cord-014516-r59usk02 1546 18 . . . cord-014516-r59usk02 1547 1 All all DT cord-014516-r59usk02 1547 2 VS VS NNP cord-014516-r59usk02 1547 3 - - HYPH cord-014516-r59usk02 1547 4 FCV FCV NNP cord-014516-r59usk02 1547 5 isolates isolate VBZ cord-014516-r59usk02 1547 6 from from IN cord-014516-r59usk02 1547 7 cats cat NNS cord-014516-r59usk02 1547 8 from from IN cord-014516-r59usk02 1547 9 the the DT cord-014516-r59usk02 1547 10 same same JJ cord-014516-r59usk02 1547 11 outbreak outbreak NN cord-014516-r59usk02 1547 12 showed show VBD cord-014516-r59usk02 1547 13 a a DT cord-014516-r59usk02 1547 14 similar similar JJ cord-014516-r59usk02 1547 15 virus virus NN cord-014516-r59usk02 1547 16 neutralization neutralization NN cord-014516-r59usk02 1547 17 pattern pattern NN cord-014516-r59usk02 1547 18 , , , cord-014516-r59usk02 1547 19 but but CC cord-014516-r59usk02 1547 20 neutralization neutralization NN cord-014516-r59usk02 1547 21 differed differ VBD cord-014516-r59usk02 1547 22 between between IN cord-014516-r59usk02 1547 23 different different JJ cord-014516-r59usk02 1547 24 outbreaks outbreak NNS cord-014516-r59usk02 1547 25 . . . cord-014516-r59usk02 1548 1 In in IN cord-014516-r59usk02 1548 2 conclusion conclusion NN cord-014516-r59usk02 1548 3 , , , cord-014516-r59usk02 1548 4 all all DT cord-014516-r59usk02 1548 5 VS VS NNP cord-014516-r59usk02 1548 6 - - HYPH cord-014516-r59usk02 1548 7 FCV FCV NNP cord-014516-r59usk02 1548 8 outbreaks outbreak NNS cord-014516-r59usk02 1548 9 involved involve VBD cord-014516-r59usk02 1548 10 multi multi JJ cord-014516-r59usk02 1548 11 - - JJ cord-014516-r59usk02 1548 12 cat cat JJ cord-014516-r59usk02 1548 13 environments environment NNS cord-014516-r59usk02 1548 14 . . . cord-014516-r59usk02 1549 1 The the DT cord-014516-r59usk02 1549 2 same same JJ cord-014516-r59usk02 1549 3 VS VS NNP cord-014516-r59usk02 1549 4 - - HYPH cord-014516-r59usk02 1549 5 FCV FCV NNP cord-014516-r59usk02 1549 6 strains strain NNS cord-014516-r59usk02 1549 7 with with IN cord-014516-r59usk02 1549 8 similar similar JJ cord-014516-r59usk02 1549 9 virus virus NN cord-014516-r59usk02 1549 10 neutralization neutralization NN cord-014516-r59usk02 1549 11 patterns pattern NNS cord-014516-r59usk02 1549 12 were be VBD cord-014516-r59usk02 1549 13 isolated isolate VBN cord-014516-r59usk02 1549 14 from from IN cord-014516-r59usk02 1549 15 cats cat NNS cord-014516-r59usk02 1549 16 from from IN cord-014516-r59usk02 1549 17 the the DT cord-014516-r59usk02 1549 18 same same JJ cord-014516-r59usk02 1549 19 outbreak outbreak NN cord-014516-r59usk02 1549 20 . . . cord-014516-r59usk02 1550 1 Not not RB cord-014516-r59usk02 1550 2 all all DT cord-014516-r59usk02 1550 3 cats cat NNS cord-014516-r59usk02 1550 4 infected infect VBN cord-014516-r59usk02 1550 5 with with IN cord-014516-r59usk02 1550 6 a a DT cord-014516-r59usk02 1550 7 VS VS NNP cord-014516-r59usk02 1550 8 - - HYPH cord-014516-r59usk02 1550 9 FCV FCV NNP cord-014516-r59usk02 1550 10 strain strain NN cord-014516-r59usk02 1550 11 developed develop VBN cord-014516-r59usk02 1550 12 disease disease NN cord-014516-r59usk02 1550 13 and and CC cord-014516-r59usk02 1550 14 mortality mortality NN cord-014516-r59usk02 1550 15 varied varied JJ cord-014516-r59usk02 1550 16 between between IN cord-014516-r59usk02 1550 17 the the DT cord-014516-r59usk02 1550 18 outbreaks outbreak NNS cord-014516-r59usk02 1550 19 . . . cord-014516-r59usk02 1551 1 The the DT cord-014516-r59usk02 1551 2 sera sera NNP cord-014516-r59usk02 1551 3 for for IN cord-014516-r59usk02 1551 4 virus virus NN cord-014516-r59usk02 1551 5 neutralization neutralization NN cord-014516-r59usk02 1551 6 were be VBD cord-014516-r59usk02 1551 7 provided provide VBN cord-014516-r59usk02 1551 8 by by IN cord-014516-r59usk02 1551 9 Merial Merial NNP cord-014516-r59usk02 1551 10 , , , cord-014516-r59usk02 1551 11 France France NNP cord-014516-r59usk02 1551 12 . . . cord-014516-r59usk02 1552 1 defined define VBN cord-014516-r59usk02 1552 2 herein herein RB cord-014516-r59usk02 1552 3 as as IN cord-014516-r59usk02 1552 4 presence presence NN cord-014516-r59usk02 1552 5 of of IN cord-014516-r59usk02 1552 6 sneezing sneeze VBG cord-014516-r59usk02 1552 7 , , , cord-014516-r59usk02 1552 8 nasal nasal NN cord-014516-r59usk02 1552 9 - - HYPH cord-014516-r59usk02 1552 10 and and CC cord-014516-r59usk02 1552 11 / / SYM cord-014516-r59usk02 1552 12 or or CC cord-014516-r59usk02 1552 13 ocular ocular JJ cord-014516-r59usk02 1552 14 discharge discharge NN cord-014516-r59usk02 1552 15 , , , cord-014516-r59usk02 1552 16 conjunctivitis conjunctivitis NN cord-014516-r59usk02 1552 17 and/or and/or CC cord-014516-r59usk02 1552 18 keratitis keratitis NN cord-014516-r59usk02 1552 19 ) ) -RRB- cord-014516-r59usk02 1552 20 , , , cord-014516-r59usk02 1552 21 but but CC cord-014516-r59usk02 1552 22 also also RB cord-014516-r59usk02 1552 23 oral oral JJ cord-014516-r59usk02 1552 24 cavity cavity NN cord-014516-r59usk02 1552 25 lesions lesion NNS cord-014516-r59usk02 1552 26 , , , cord-014516-r59usk02 1552 27 chronic chronic JJ cord-014516-r59usk02 1552 28 stomatitis stomatitis NN cord-014516-r59usk02 1552 29 , , , cord-014516-r59usk02 1552 30 limping limp VBG cord-014516-r59usk02 1552 31 syndrome syndrome NN cord-014516-r59usk02 1552 32 and and CC cord-014516-r59usk02 1552 33 , , , cord-014516-r59usk02 1552 34 rarely rarely RB cord-014516-r59usk02 1552 35 , , , cord-014516-r59usk02 1552 36 virulent virulent JJ cord-014516-r59usk02 1552 37 systemic systemic JJ cord-014516-r59usk02 1552 38 disease disease NN cord-014516-r59usk02 1552 39 . . . cord-014516-r59usk02 1553 1 The the DT cord-014516-r59usk02 1553 2 aims aim NNS cord-014516-r59usk02 1553 3 of of IN cord-014516-r59usk02 1553 4 the the DT cord-014516-r59usk02 1553 5 present present JJ cord-014516-r59usk02 1553 6 study study NN cord-014516-r59usk02 1553 7 were be VBD cord-014516-r59usk02 1553 8 to to TO cord-014516-r59usk02 1553 9 compare compare VB cord-014516-r59usk02 1553 10 cats cat NNS cord-014516-r59usk02 1553 11 suspected suspect VBN cord-014516-r59usk02 1553 12 of of IN cord-014516-r59usk02 1553 13 FCV FCV NNP cord-014516-r59usk02 1553 14 ( ( -LRB- cord-014516-r59usk02 1553 15 FCV FCV NNP cord-014516-r59usk02 1553 16 - - HYPH cord-014516-r59usk02 1553 17 SC SC NNP cord-014516-r59usk02 1553 18 ) ) -RRB- cord-014516-r59usk02 1553 19 based base VBN cord-014516-r59usk02 1553 20 on on IN cord-014516-r59usk02 1553 21 clinical clinical JJ cord-014516-r59usk02 1553 22 symptoms symptom NNS cord-014516-r59usk02 1553 23 and and CC cord-014516-r59usk02 1553 24 healthy healthy JJ cord-014516-r59usk02 1553 25 controls control NNS cord-014516-r59usk02 1553 26 ( ( -LRB- cord-014516-r59usk02 1553 27 controls control NNS cord-014516-r59usk02 1553 28 ) ) -RRB- cord-014516-r59usk02 1553 29 and and CC cord-014516-r59usk02 1553 30 to to TO cord-014516-r59usk02 1553 31 investigate investigate VB cord-014516-r59usk02 1553 32 potential potential JJ cord-014516-r59usk02 1553 33 risk risk NN cord-014516-r59usk02 1553 34 and and CC cord-014516-r59usk02 1553 35 protective protective JJ cord-014516-r59usk02 1553 36 factors factor NNS cord-014516-r59usk02 1553 37 , , , cord-014516-r59usk02 1553 38 such such JJ cord-014516-r59usk02 1553 39 as as IN cord-014516-r59usk02 1553 40 co co NN cord-014516-r59usk02 1553 41 - - NN cord-014516-r59usk02 1553 42 infection infection NN cord-014516-r59usk02 1553 43 with with IN cord-014516-r59usk02 1553 44 feline feline JJ cord-014516-r59usk02 1553 45 herpesvirus-1 herpesvirus-1 NNP cord-014516-r59usk02 1553 46 ( ( -LRB- cord-014516-r59usk02 1553 47 FHV-1 FHV-1 NNP cord-014516-r59usk02 1553 48 ) ) -RRB- cord-014516-r59usk02 1553 49 , , , cord-014516-r59usk02 1553 50 Mycoplasma Mycoplasma NNP cord-014516-r59usk02 1553 51 felis felis NN cord-014516-r59usk02 1553 52 , , , cord-014516-r59usk02 1553 53 Chlamydophila Chlamydophila NNP cord-014516-r59usk02 1553 54 felis felis NN cord-014516-r59usk02 1553 55 , , , cord-014516-r59usk02 1553 56 Bordetella Bordetella NNP cord-014516-r59usk02 1553 57 bronchiseptica bronchiseptica NNP cord-014516-r59usk02 1553 58 and and CC cord-014516-r59usk02 1553 59 feline feline JJ cord-014516-r59usk02 1553 60 retroviruses retrovirus NNS cord-014516-r59usk02 1553 61 , , , cord-014516-r59usk02 1553 62 vaccination vaccination NN cord-014516-r59usk02 1553 63 , , , cord-014516-r59usk02 1553 64 gender gender NN cord-014516-r59usk02 1553 65 , , , cord-014516-r59usk02 1553 66 age age NN cord-014516-r59usk02 1553 67 , , , cord-014516-r59usk02 1553 68 breed breed NN cord-014516-r59usk02 1553 69 , , , cord-014516-r59usk02 1553 70 housing housing NN cord-014516-r59usk02 1553 71 and and CC cord-014516-r59usk02 1553 72 corticosteroid corticosteroid NN cord-014516-r59usk02 1553 73 and and CC cord-014516-r59usk02 1553 74 antibiotic antibiotic JJ cord-014516-r59usk02 1553 75 treatment treatment NN cord-014516-r59usk02 1553 76 . . . cord-014516-r59usk02 1554 1 Oropharyngeal oropharyngeal RB cord-014516-r59usk02 1554 2 , , , cord-014516-r59usk02 1554 3 nasal nasal NN cord-014516-r59usk02 1554 4 and and CC cord-014516-r59usk02 1554 5 conjunctival conjunctival NN cord-014516-r59usk02 1554 6 swabs swab NNS cord-014516-r59usk02 1554 7 from from IN cord-014516-r59usk02 1554 8 200 200 CD cord-014516-r59usk02 1554 9 FCV FCV NNP cord-014516-r59usk02 1554 10 - - HYPH cord-014516-r59usk02 1554 11 SC SC NNP cord-014516-r59usk02 1554 12 and and CC cord-014516-r59usk02 1554 13 100 100 CD cord-014516-r59usk02 1554 14 controls control NNS cord-014516-r59usk02 1554 15 were be VBD cord-014516-r59usk02 1554 16 collected collect VBN cord-014516-r59usk02 1554 17 into into IN cord-014516-r59usk02 1554 18 transport transport NN cord-014516-r59usk02 1554 19 medium medium NN cord-014516-r59usk02 1554 20 , , , cord-014516-r59usk02 1554 21 processed process VBN cord-014516-r59usk02 1554 22 within within IN cord-014516-r59usk02 1554 23 96 96 CD cord-014516-r59usk02 1554 24 hours hour NNS cord-014516-r59usk02 1554 25 after after IN cord-014516-r59usk02 1554 26 collection collection NN cord-014516-r59usk02 1554 27 and and CC cord-014516-r59usk02 1554 28 analyzed analyze VBD cord-014516-r59usk02 1554 29 for for IN cord-014516-r59usk02 1554 30 FCV FCV NNP cord-014516-r59usk02 1554 31 by by IN cord-014516-r59usk02 1554 32 virus virus NN cord-014516-r59usk02 1554 33 isolation isolation NN cord-014516-r59usk02 1554 34 and and CC cord-014516-r59usk02 1554 35 for for IN cord-014516-r59usk02 1554 36 all all DT cord-014516-r59usk02 1554 37 tested test VBN cord-014516-r59usk02 1554 38 pathogens pathogen NNS cord-014516-r59usk02 1554 39 using use VBG cord-014516-r59usk02 1554 40 molecular molecular JJ cord-014516-r59usk02 1554 41 assays assay NNS cord-014516-r59usk02 1554 42 . . . cord-014516-r59usk02 1555 1 The the DT cord-014516-r59usk02 1555 2 samples sample NNS cord-014516-r59usk02 1555 3 were be VBD cord-014516-r59usk02 1555 4 collected collect VBN cord-014516-r59usk02 1555 5 by by IN cord-014516-r59usk02 1555 6 randomly randomly RB cord-014516-r59usk02 1555 7 selected select VBN cord-014516-r59usk02 1555 8 veterinary veterinary JJ cord-014516-r59usk02 1555 9 practices practice NNS cord-014516-r59usk02 1555 10 in in IN cord-014516-r59usk02 1555 11 20 20 CD cord-014516-r59usk02 1555 12 different different JJ cord-014516-r59usk02 1555 13 areas area NNS cord-014516-r59usk02 1555 14 of of IN cord-014516-r59usk02 1555 15 Switzerland Switzerland NNP cord-014516-r59usk02 1555 16 ( ( -LRB- cord-014516-r59usk02 1555 17 10 10 CD cord-014516-r59usk02 1555 18 FCV FCV NNP cord-014516-r59usk02 1555 19 - - HYPH cord-014516-r59usk02 1555 20 SC SC NNP cord-014516-r59usk02 1555 21 and and CC cord-014516-r59usk02 1555 22 5 5 CD cord-014516-r59usk02 1555 23 controls/ controls/ CD cord-014516-r59usk02 1555 24 area area NN cord-014516-r59usk02 1555 25 ) ) -RRB- cord-014516-r59usk02 1555 26 . . . cord-014516-r59usk02 1556 1 To to TO cord-014516-r59usk02 1556 2 record record VB cord-014516-r59usk02 1556 3 clinical clinical JJ cord-014516-r59usk02 1556 4 data datum NNS cord-014516-r59usk02 1556 5 , , , cord-014516-r59usk02 1556 6 retroviral retroviral JJ cord-014516-r59usk02 1556 7 status status NN cord-014516-r59usk02 1556 8 and and CC cord-014516-r59usk02 1556 9 vaccination vaccination NN cord-014516-r59usk02 1556 10 history history NN cord-014516-r59usk02 1556 11 of of IN cord-014516-r59usk02 1556 12 the the DT cord-014516-r59usk02 1556 13 cats cat NNS cord-014516-r59usk02 1556 14 , , , cord-014516-r59usk02 1556 15 a a DT cord-014516-r59usk02 1556 16 questionnaire questionnaire NN cord-014516-r59usk02 1556 17 was be VBD cord-014516-r59usk02 1556 18 filled fill VBN cord-014516-r59usk02 1556 19 out out RP cord-014516-r59usk02 1556 20 by by IN cord-014516-r59usk02 1556 21 the the DT cord-014516-r59usk02 1556 22 private private JJ cord-014516-r59usk02 1556 23 veterinarian veterinarian NN cord-014516-r59usk02 1556 24 . . . cord-014516-r59usk02 1557 1 The the DT cord-014516-r59usk02 1557 2 seven seven CD cord-014516-r59usk02 1557 3 tested test VBN cord-014516-r59usk02 1557 4 pathogens pathogen NNS cord-014516-r59usk02 1557 5 were be VBD cord-014516-r59usk02 1557 6 found find VBN cord-014516-r59usk02 1557 7 in in IN cord-014516-r59usk02 1557 8 the the DT cord-014516-r59usk02 1557 9 investigated investigate VBN cord-014516-r59usk02 1557 10 population population NN cord-014516-r59usk02 1557 11 . . . cord-014516-r59usk02 1558 1 The the DT cord-014516-r59usk02 1558 2 prevalence prevalence NN cord-014516-r59usk02 1558 3 ( ( -LRB- cord-014516-r59usk02 1558 4 FCV FCV NNP cord-014516-r59usk02 1558 5 - - HYPH cord-014516-r59usk02 1558 6 SC SC NNP cord-014516-r59usk02 1558 7 vs. vs. FW cord-014516-r59usk02 1558 8 controls control NNS cord-014516-r59usk02 1558 9 ) ) -RRB- cord-014516-r59usk02 1558 10 was be VBD cord-014516-r59usk02 1558 11 : : : cord-014516-r59usk02 1558 12 FCV FCV NNP cord-014516-r59usk02 1558 13 45 45 CD cord-014516-r59usk02 1558 14 % % NN cord-014516-r59usk02 1558 15 vs. vs. CC cord-014516-r59usk02 1558 16 8 8 CD cord-014516-r59usk02 1558 17 % % NN cord-014516-r59usk02 1558 18 ; ; . cord-014516-r59usk02 1559 1 FHV-1 FHV-1 NNP cord-014516-r59usk02 1559 2 20 20 CD cord-014516-r59usk02 1559 3 % % NN cord-014516-r59usk02 1559 4 vs. vs. IN cord-014516-r59usk02 1559 5 9 9 CD cord-014516-r59usk02 1559 6 % % NN cord-014516-r59usk02 1559 7 , , , cord-014516-r59usk02 1559 8 C. C. NNP cord-014516-r59usk02 1559 9 felis felis NN cord-014516-r59usk02 1559 10 8 8 CD cord-014516-r59usk02 1559 11 % % NN cord-014516-r59usk02 1559 12 vs. vs. IN cord-014516-r59usk02 1559 13 1 1 CD cord-014516-r59usk02 1559 14 % % NN cord-014516-r59usk02 1559 15 , , , cord-014516-r59usk02 1559 16 B. B. NNP cord-014516-r59usk02 1559 17 bronchiseptica bronchiseptica NNP cord-014516-r59usk02 1559 18 4 4 CD cord-014516-r59usk02 1559 19 % % NN cord-014516-r59usk02 1559 20 vs. vs. IN cord-014516-r59usk02 1559 21 2 2 CD cord-014516-r59usk02 1559 22 % % NN cord-014516-r59usk02 1559 23 , , , cord-014516-r59usk02 1559 24 M. M. NNP cord-014516-r59usk02 1559 25 felis felis NN cord-014516-r59usk02 1559 26 48 48 CD cord-014516-r59usk02 1559 27 % % NN cord-014516-r59usk02 1559 28 vs. vs. CC cord-014516-r59usk02 1559 29 31 31 CD cord-014516-r59usk02 1559 30 % % NN cord-014516-r59usk02 1559 31 , , , cord-014516-r59usk02 1559 32 Feline feline JJ cord-014516-r59usk02 1559 33 leukemia leukemia NN cord-014516-r59usk02 1559 34 virus virus NN cord-014516-r59usk02 1559 35 2 2 CD cord-014516-r59usk02 1559 36 % % NN cord-014516-r59usk02 1559 37 vs. vs. IN cord-014516-r59usk02 1559 38 1 1 CD cord-014516-r59usk02 1559 39 % % NN cord-014516-r59usk02 1559 40 and and CC cord-014516-r59usk02 1559 41 Feline feline JJ cord-014516-r59usk02 1559 42 immunodeficiency immunodeficiency NN cord-014516-r59usk02 1559 43 virus virus NN cord-014516-r59usk02 1559 44 2 2 CD cord-014516-r59usk02 1559 45 % % NN cord-014516-r59usk02 1559 46 vs. vs. IN cord-014516-r59usk02 1559 47 1 1 CD cord-014516-r59usk02 1559 48 % % NN cord-014516-r59usk02 1559 49 . . . cord-014516-r59usk02 1560 1 FCV FCV NNP cord-014516-r59usk02 1560 2 - - HYPH cord-014516-r59usk02 1560 3 SC SC NNP cord-014516-r59usk02 1560 4 were be VBD cord-014516-r59usk02 1560 5 positive positive JJ cord-014516-r59usk02 1560 6 for for IN cord-014516-r59usk02 1560 7 FCV FCV NNP cord-014516-r59usk02 1560 8 significantly significantly RB cord-014516-r59usk02 1560 9 more more RBR cord-014516-r59usk02 1560 10 often often RB cord-014516-r59usk02 1560 11 compared compare VBN cord-014516-r59usk02 1560 12 with with IN cord-014516-r59usk02 1560 13 controls control NNS cord-014516-r59usk02 1560 14 ( ( -LRB- cord-014516-r59usk02 1560 15 OR or CC cord-014516-r59usk02 1560 16 9.2 9.2 CD cord-014516-r59usk02 1560 17 ) ) -RRB- cord-014516-r59usk02 1560 18 and and CC cord-014516-r59usk02 1560 19 shed shed VBD cord-014516-r59usk02 1560 20 more more JJR cord-014516-r59usk02 1560 21 FCV FCV NNP cord-014516-r59usk02 1560 22 . . . cord-014516-r59usk02 1561 1 Co Co NNS cord-014516-r59usk02 1561 2 - - NNS cord-014516-r59usk02 1561 3 infections infection NNS cord-014516-r59usk02 1561 4 with with IN cord-014516-r59usk02 1561 5 up up IN cord-014516-r59usk02 1561 6 to to TO cord-014516-r59usk02 1561 7 four four CD cord-014516-r59usk02 1561 8 pathogens pathogen NNS cord-014516-r59usk02 1561 9 were be VBD cord-014516-r59usk02 1561 10 detected detect VBN cord-014516-r59usk02 1561 11 ; ; : cord-014516-r59usk02 1561 12 FCV FCV NNP cord-014516-r59usk02 1561 13 - - HYPH cord-014516-r59usk02 1561 14 SC SC NNP cord-014516-r59usk02 1561 15 were be VBD cord-014516-r59usk02 1561 16 significantly significantly RB cord-014516-r59usk02 1561 17 more more RBR cord-014516-r59usk02 1561 18 frequently frequently RB cord-014516-r59usk02 1561 19 co co JJ cord-014516-r59usk02 1561 20 - - JJ cord-014516-r59usk02 1561 21 infected infected JJ cord-014516-r59usk02 1561 22 ( ( -LRB- cord-014516-r59usk02 1561 23 40 40 CD cord-014516-r59usk02 1561 24 % % NN cord-014516-r59usk02 1561 25 ) ) -RRB- cord-014516-r59usk02 1561 26 compared compare VBN cord-014516-r59usk02 1561 27 with with IN cord-014516-r59usk02 1561 28 controls control NNS cord-014516-r59usk02 1561 29 ( ( -LRB- cord-014516-r59usk02 1561 30 14 14 CD cord-014516-r59usk02 1561 31 % % NN cord-014516-r59usk02 1561 32 ) ) -RRB- cord-014516-r59usk02 1561 33 . . . cord-014516-r59usk02 1562 1 Gingivostomatitis gingivostomatitis JJ cord-014516-r59usk02 1562 2 and and CC cord-014516-r59usk02 1562 3 oral oral JJ cord-014516-r59usk02 1562 4 ulceration ulceration NN cord-014516-r59usk02 1562 5 but but CC cord-014516-r59usk02 1562 6 not not RB cord-014516-r59usk02 1562 7 URTD URTD NNP cord-014516-r59usk02 1562 8 were be VBD cord-014516-r59usk02 1562 9 highly highly RB cord-014516-r59usk02 1562 10 associated associate VBN cord-014516-r59usk02 1562 11 with with IN cord-014516-r59usk02 1562 12 FCV FCV NNP cord-014516-r59usk02 1562 13 infection infection NN cord-014516-r59usk02 1562 14 . . . cord-014516-r59usk02 1563 1 In in IN cord-014516-r59usk02 1563 2 contrast contrast NN cord-014516-r59usk02 1563 3 , , , cord-014516-r59usk02 1563 4 C. C. NNP cord-014516-r59usk02 1563 5 felis felis NN cord-014516-r59usk02 1563 6 was be VBD cord-014516-r59usk02 1563 7 associated associate VBN cord-014516-r59usk02 1563 8 with with IN cord-014516-r59usk02 1563 9 URTD URTD NNP cord-014516-r59usk02 1563 10 ; ; : cord-014516-r59usk02 1563 11 FHV-1 FHV-1 NNP cord-014516-r59usk02 1563 12 was be VBD cord-014516-r59usk02 1563 13 associated associate VBN cord-014516-r59usk02 1563 14 with with IN cord-014516-r59usk02 1563 15 nasal nasal NN cord-014516-r59usk02 1563 16 and and CC cord-014516-r59usk02 1563 17 ocular ocular JJ cord-014516-r59usk02 1563 18 discharge discharge NN cord-014516-r59usk02 1563 19 and and CC cord-014516-r59usk02 1563 20 M. M. NNP cord-014516-r59usk02 1563 21 felis felis NN cord-014516-r59usk02 1563 22 with with IN cord-014516-r59usk02 1563 23 conjunctivitis conjunctivitis NN cord-014516-r59usk02 1563 24 and and CC cord-014516-r59usk02 1563 25 ocular ocular JJ cord-014516-r59usk02 1563 26 discharge discharge NN cord-014516-r59usk02 1563 27 . . . cord-014516-r59usk02 1564 1 Risk risk NN cord-014516-r59usk02 1564 2 factors factor NNS cord-014516-r59usk02 1564 3 for for IN cord-014516-r59usk02 1564 4 FCV FCV NNP cord-014516-r59usk02 1564 5 infection infection NN cord-014516-r59usk02 1564 6 were be VBD cord-014516-r59usk02 1564 7 housing housing NN cord-014516-r59usk02 1564 8 in in IN cord-014516-r59usk02 1564 9 groups group NNS cord-014516-r59usk02 1564 10 ( ( -LRB- cord-014516-r59usk02 1564 11 especially especially RB cord-014516-r59usk02 1564 12 ≥4 ≥4 JJ cord-014516-r59usk02 1564 13 cats cat NNS cord-014516-r59usk02 1564 14 ) ) -RRB- cord-014516-r59usk02 1564 15 , , , cord-014516-r59usk02 1564 16 an an DT cord-014516-r59usk02 1564 17 intact intact JJ cord-014516-r59usk02 1564 18 gender gender NN cord-014516-r59usk02 1564 19 , , , cord-014516-r59usk02 1564 20 Maine Maine NNP cord-014516-r59usk02 1564 21 Coon Coon NNP cord-014516-r59usk02 1564 22 breed breed NN cord-014516-r59usk02 1564 23 and and CC cord-014516-r59usk02 1564 24 corticosteroid corticosteroid NN cord-014516-r59usk02 1564 25 therapy therapy NN cord-014516-r59usk02 1564 26 . . . cord-014516-r59usk02 1565 1 FCV FCV NNP cord-014516-r59usk02 1565 2 - - HYPH cord-014516-r59usk02 1565 3 positive positive JJ cord-014516-r59usk02 1565 4 cats cat NNS cord-014516-r59usk02 1565 5 with with IN cord-014516-r59usk02 1565 6 gingivostomatitis gingivostomatitis NNP cord-014516-r59usk02 1565 7 were be VBD cord-014516-r59usk02 1565 8 older old JJR cord-014516-r59usk02 1565 9 and and CC cord-014516-r59usk02 1565 10 more more RBR cord-014516-r59usk02 1565 11 commonly commonly RB cord-014516-r59usk02 1565 12 vaccinated vaccinate VBN cord-014516-r59usk02 1565 13 than than IN cord-014516-r59usk02 1565 14 FCV FCV NNP cord-014516-r59usk02 1565 15 - - HYPH cord-014516-r59usk02 1565 16 positive positive JJ cord-014516-r59usk02 1565 17 cats cat NNS cord-014516-r59usk02 1565 18 without without IN cord-014516-r59usk02 1565 19 gingivostomatitis gingivostomatitis NNP cord-014516-r59usk02 1565 20 . . . cord-014516-r59usk02 1566 1 Moreover moreover RB cord-014516-r59usk02 1566 2 they -PRON- PRP cord-014516-r59usk02 1566 3 shed shed VBP cord-014516-r59usk02 1566 4 more more JJR cord-014516-r59usk02 1566 5 FCV FCV NNP cord-014516-r59usk02 1566 6 than than IN cord-014516-r59usk02 1566 7 cats cat NNS cord-014516-r59usk02 1566 8 with with IN cord-014516-r59usk02 1566 9 URTD URTD NNP cord-014516-r59usk02 1566 10 . . . cord-014516-r59usk02 1567 1 Vaccination vaccination NN cord-014516-r59usk02 1567 2 and and CC cord-014516-r59usk02 1567 3 primary primary JJ cord-014516-r59usk02 1567 4 immunization immunization NN cord-014516-r59usk02 1567 5 defined define VBN cord-014516-r59usk02 1567 6 as as IN cord-014516-r59usk02 1568 1 two two CD cord-014516-r59usk02 1568 2 vaccinations vaccination NNS cord-014516-r59usk02 1568 3 2 2 CD cord-014516-r59usk02 1568 4 - - SYM cord-014516-r59usk02 1568 5 6 6 CD cord-014516-r59usk02 1568 6 weeks week NNS cord-014516-r59usk02 1568 7 apart apart RB cord-014516-r59usk02 1568 8 with with IN cord-014516-r59usk02 1568 9 the the DT cord-014516-r59usk02 1568 10 same same JJ cord-014516-r59usk02 1568 11 vaccine vaccine NN cord-014516-r59usk02 1568 12 brand brand NN cord-014516-r59usk02 1568 13 were be VBD cord-014516-r59usk02 1568 14 protective protective JJ cord-014516-r59usk02 1568 15 factors factor NNS cord-014516-r59usk02 1568 16 against against IN cord-014516-r59usk02 1568 17 FCV FCV NNP cord-014516-r59usk02 1568 18 but but CC cord-014516-r59usk02 1568 19 not not RB cord-014516-r59usk02 1568 20 FHV-1 FHV-1 NNP cord-014516-r59usk02 1568 21 infection infection NN cord-014516-r59usk02 1568 22 . . . cord-014516-r59usk02 1569 1 Vaccination vaccination NN cord-014516-r59usk02 1569 2 was be VBD cord-014516-r59usk02 1569 3 associated associate VBN cord-014516-r59usk02 1569 4 with with IN cord-014516-r59usk02 1569 5 a a DT cord-014516-r59usk02 1569 6 decreased decrease VBN cord-014516-r59usk02 1569 7 incidence incidence NN cord-014516-r59usk02 1569 8 of of IN cord-014516-r59usk02 1569 9 URTD URTD NNP cord-014516-r59usk02 1569 10 in in IN cord-014516-r59usk02 1569 11 FCV FCV NNP cord-014516-r59usk02 1569 12 - - HYPH cord-014516-r59usk02 1569 13 infected infect VBN cord-014516-r59usk02 1569 14 cats cat NNS cord-014516-r59usk02 1569 15 ( ( -LRB- cord-014516-r59usk02 1569 16 OR or CC cord-014516-r59usk02 1569 17 0.3 0.3 CD cord-014516-r59usk02 1569 18 ) ) -RRB- cord-014516-r59usk02 1569 19 . . . cord-014516-r59usk02 1570 1 Further further JJ cord-014516-r59usk02 1570 2 analyses analysis NNS cord-014516-r59usk02 1570 3 will will MD cord-014516-r59usk02 1570 4 investigate investigate VB cord-014516-r59usk02 1570 5 cross cross JJ cord-014516-r59usk02 1570 6 - - JJ cord-014516-r59usk02 1570 7 neutralization neutralization JJ cord-014516-r59usk02 1570 8 patterns pattern NNS cord-014516-r59usk02 1570 9 of of IN cord-014516-r59usk02 1570 10 the the DT cord-014516-r59usk02 1570 11 prevailing prevail VBG cord-014516-r59usk02 1570 12 FCV FCV NNP cord-014516-r59usk02 1570 13 isolates isolate NNS cord-014516-r59usk02 1570 14 . . . cord-014516-r59usk02 1571 1 Conflicts conflict NNS cord-014516-r59usk02 1571 2 of of IN cord-014516-r59usk02 1571 3 interest interest NN cord-014516-r59usk02 1571 4 : : : cord-014516-r59usk02 1571 5 The the DT cord-014516-r59usk02 1571 6 study study NN cord-014516-r59usk02 1571 7 was be VBD cord-014516-r59usk02 1571 8 partially partially RB cord-014516-r59usk02 1571 9 funded fund VBN cord-014516-r59usk02 1571 10 by by IN cord-014516-r59usk02 1571 11 Merial Merial NNP cord-014516-r59usk02 1571 12 , , , cord-014516-r59usk02 1571 13 France France NNP cord-014516-r59usk02 1571 14 , , , cord-014516-r59usk02 1571 15 and and CC cord-014516-r59usk02 1571 16 Biokema Biokema NNP cord-014516-r59usk02 1571 17 , , , cord-014516-r59usk02 1571 18 Switzerland Switzerland NNP cord-014516-r59usk02 1571 19 . . . cord-014516-r59usk02 1572 1 Antibody antibody NN cord-014516-r59usk02 1572 2 preparations preparation NNS cord-014516-r59usk02 1572 3 are be VBP cord-014516-r59usk02 1572 4 commonly commonly RB cord-014516-r59usk02 1572 5 used use VBN cord-014516-r59usk02 1572 6 for for IN cord-014516-r59usk02 1572 7 the the DT cord-014516-r59usk02 1572 8 treatment treatment NN cord-014516-r59usk02 1572 9 of of IN cord-014516-r59usk02 1572 10 feline feline JJ cord-014516-r59usk02 1572 11 upper upper JJ cord-014516-r59usk02 1572 12 respiratory respiratory JJ cord-014516-r59usk02 1572 13 tract tract NN cord-014516-r59usk02 1572 14 disease disease NN cord-014516-r59usk02 1572 15 ( ( -LRB- cord-014516-r59usk02 1572 16 FURTD FURTD NNP cord-014516-r59usk02 1572 17 ) ) -RRB- cord-014516-r59usk02 1572 18 , , , cord-014516-r59usk02 1572 19 although although IN cord-014516-r59usk02 1572 20 their -PRON- PRP$ cord-014516-r59usk02 1572 21 efficacy efficacy NN cord-014516-r59usk02 1572 22 has have VBZ cord-014516-r59usk02 1572 23 not not RB cord-014516-r59usk02 1572 24 been be VBN cord-014516-r59usk02 1572 25 proven prove VBN cord-014516-r59usk02 1572 26 . . . cord-014516-r59usk02 1573 1 The the DT cord-014516-r59usk02 1573 2 aim aim NN cord-014516-r59usk02 1573 3 of of IN cord-014516-r59usk02 1573 4 this this DT cord-014516-r59usk02 1573 5 study study NN cord-014516-r59usk02 1573 6 was be VBD cord-014516-r59usk02 1573 7 to to TO cord-014516-r59usk02 1573 8 evaluate evaluate VB cord-014516-r59usk02 1573 9 efficacy efficacy NN cord-014516-r59usk02 1573 10 of of IN cord-014516-r59usk02 1573 11 a a DT cord-014516-r59usk02 1573 12 commercial commercial JJ cord-014516-r59usk02 1573 13 serum serum NN cord-014516-r59usk02 1573 14 containing contain VBG cord-014516-r59usk02 1573 15 antibodies antibody NNS cord-014516-r59usk02 1573 16 against against IN cord-014516-r59usk02 1573 17 feline feline JJ cord-014516-r59usk02 1573 18 herpesvirus-1 herpesvirus-1 NNP cord-014516-r59usk02 1573 19 ( ( -LRB- cord-014516-r59usk02 1573 20 FHV-1 FHV-1 NNP cord-014516-r59usk02 1573 21 ) ) -RRB- cord-014516-r59usk02 1573 22 and and CC cord-014516-r59usk02 1573 23 feline feline JJ cord-014516-r59usk02 1573 24 calicivirus calicivirus NNP cord-014516-r59usk02 1573 25 ( ( -LRB- cord-014516-r59usk02 1573 26 FCV FCV NNP cord-014516-r59usk02 1573 27 ) ) -RRB- cord-014516-r59usk02 1573 28 in in IN cord-014516-r59usk02 1573 29 cats cat NNS cord-014516-r59usk02 1573 30 with with IN cord-014516-r59usk02 1573 31 acute acute JJ cord-014516-r59usk02 1573 32 viral viral JJ cord-014516-r59usk02 1573 33 FURTD FURTD NNP cord-014516-r59usk02 1573 34 . . . cord-014516-r59usk02 1574 1 This this DT cord-014516-r59usk02 1574 2 prospective prospective NN cord-014516-r59usk02 1574 3 , , , cord-014516-r59usk02 1574 4 randomized randomized JJ cord-014516-r59usk02 1574 5 , , , cord-014516-r59usk02 1574 6 placebo placebo NN cord-014516-r59usk02 1574 7 - - HYPH cord-014516-r59usk02 1574 8 controlled control VBN cord-014516-r59usk02 1574 9 , , , cord-014516-r59usk02 1574 10 double double JJ cord-014516-r59usk02 1574 11 - - HYPH cord-014516-r59usk02 1574 12 blind blind JJ cord-014516-r59usk02 1574 13 study study NN cord-014516-r59usk02 1574 14 included include VBD cord-014516-r59usk02 1574 15 42 42 CD cord-014516-r59usk02 1574 16 cats cat NNS cord-014516-r59usk02 1574 17 with with IN cord-014516-r59usk02 1574 18 acute acute JJ cord-014516-r59usk02 1574 19 ( ( -LRB- cord-014516-r59usk02 1574 20 < < NNP cord-014516-r59usk02 1574 21 7 7 CD cord-014516-r59usk02 1574 22 days day NNS cord-014516-r59usk02 1574 23 ) ) -RRB- cord-014516-r59usk02 1574 24 clinical clinical JJ cord-014516-r59usk02 1574 25 signs sign NNS cord-014516-r59usk02 1574 26 of of IN cord-014516-r59usk02 1574 27 FHV-1 FHV-1 NNP cord-014516-r59usk02 1574 28 and/or and/or CC cord-014516-r59usk02 1574 29 FCV FCV NNP cord-014516-r59usk02 1574 30 infection infection NN cord-014516-r59usk02 1574 31 ( ( -LRB- cord-014516-r59usk02 1574 32 confirmed confirm VBN cord-014516-r59usk02 1574 33 by by IN cord-014516-r59usk02 1574 34 quantitative quantitative JJ cord-014516-r59usk02 1574 35 PCR PCR NNP cord-014516-r59usk02 1574 36 ) ) -RRB- cord-014516-r59usk02 1574 37 . . . cord-014516-r59usk02 1575 1 All all DT cord-014516-r59usk02 1575 2 cats cat NNS cord-014516-r59usk02 1575 3 received receive VBD cord-014516-r59usk02 1575 4 symptomatic symptomatic JJ cord-014516-r59usk02 1575 5 treatment treatment NN cord-014516-r59usk02 1575 6 and and CC cord-014516-r59usk02 1575 7 either either CC cord-014516-r59usk02 1575 8 hyperimmune hyperimmune NNP cord-014516-r59usk02 1575 9 serum serum NNP cord-014516-r59usk02 1575 10 ( ( -LRB- cord-014516-r59usk02 1575 11 n n NN cord-014516-r59usk02 1575 12 = = SYM cord-014516-r59usk02 1575 13 22 22 CD cord-014516-r59usk02 1575 14 ) ) -RRB- cord-014516-r59usk02 1576 1 ( ( -LRB- cord-014516-r59usk02 1576 2 ≤12 ≤12 CD cord-014516-r59usk02 1576 3 weeks week NNS cord-014516-r59usk02 1576 4 2 2 CD cord-014516-r59usk02 1576 5 ml ml NNS cord-014516-r59usk02 1576 6 , , , cord-014516-r59usk02 1576 7 > > XX cord-014516-r59usk02 1577 1 12 12 CD cord-014516-r59usk02 1577 2 weeks week NNS cord-014516-r59usk02 1577 3 4 4 CD cord-014516-r59usk02 1577 4 ml ml NNS cord-014516-r59usk02 1577 5 , , , cord-014516-r59usk02 1577 6 subcutaneously subcutaneously RB cord-014516-r59usk02 1577 7 q24 q24 NNP cord-014516-r59usk02 1577 8 h h NN cord-014516-r59usk02 1577 9 , , , cord-014516-r59usk02 1577 10 topically topically RB cord-014516-r59usk02 1577 11 into into IN cord-014516-r59usk02 1577 12 eyes eye NNS cord-014516-r59usk02 1577 13 , , , cord-014516-r59usk02 1577 14 nostrils nostril NNS cord-014516-r59usk02 1577 15 , , , cord-014516-r59usk02 1577 16 and and CC cord-014516-r59usk02 1577 17 mouth mouth NNP cord-014516-r59usk02 1577 18 q8 q8 NNP cord-014516-r59usk02 1577 19 h h NNP cord-014516-r59usk02 1577 20 ) ) -RRB- cord-014516-r59usk02 1577 21 or or CC cord-014516-r59usk02 1577 22 saline saline NNP cord-014516-r59usk02 1577 23 ( ( -LRB- cord-014516-r59usk02 1577 24 n n NN cord-014516-r59usk02 1577 25 = = SYM cord-014516-r59usk02 1577 26 20 20 CD cord-014516-r59usk02 1577 27 ) ) -RRB- cord-014516-r59usk02 1577 28 for for IN cord-014516-r59usk02 1577 29 three three CD cord-014516-r59usk02 1577 30 days day NNS cord-014516-r59usk02 1577 31 . . . cord-014516-r59usk02 1578 1 Clinical clinical JJ cord-014516-r59usk02 1578 2 signs sign NNS cord-014516-r59usk02 1578 3 , , , cord-014516-r59usk02 1578 4 including include VBG cord-014516-r59usk02 1578 5 a a DT cord-014516-r59usk02 1578 6 ' ' `` cord-014516-r59usk02 1578 7 FURTD FURTD NNP cord-014516-r59usk02 1578 8 score score NN cord-014516-r59usk02 1578 9 ' ' '' cord-014516-r59usk02 1578 10 and and CC cord-014516-r59usk02 1578 11 general general JJ cord-014516-r59usk02 1578 12 health health NN cord-014516-r59usk02 1578 13 status status NN cord-014516-r59usk02 1578 14 , , , cord-014516-r59usk02 1578 15 were be VBD cord-014516-r59usk02 1578 16 recorded record VBN cord-014516-r59usk02 1578 17 daily daily RB cord-014516-r59usk02 1578 18 ( ( -LRB- cord-014516-r59usk02 1578 19 day day NN cord-014516-r59usk02 1578 20 0 0 CD cord-014516-r59usk02 1578 21 to to IN cord-014516-r59usk02 1578 22 7 7 CD cord-014516-r59usk02 1578 23 and and CC cord-014516-r59usk02 1578 24 on on IN cord-014516-r59usk02 1578 25 day day NN cord-014516-r59usk02 1578 26 21 21 CD cord-014516-r59usk02 1578 27 ) ) -RRB- cord-014516-r59usk02 1578 28 . . . cord-014516-r59usk02 1579 1 FCV FCV NNP cord-014516-r59usk02 1579 2 shedding shed VBG cord-014516-r59usk02 1579 3 was be VBD cord-014516-r59usk02 1579 4 determined determine VBN cord-014516-r59usk02 1579 5 on on IN cord-014516-r59usk02 1579 6 day day NN cord-014516-r59usk02 1579 7 0 0 CD cord-014516-r59usk02 1579 8 and and CC cord-014516-r59usk02 1579 9 21 21 CD cord-014516-r59usk02 1579 10 . . . cord-014516-r59usk02 1580 1 Statistical statistical JJ cord-014516-r59usk02 1580 2 analyses analysis NNS cord-014516-r59usk02 1580 3 included include VBD cord-014516-r59usk02 1580 4 one one CD cord-014516-r59usk02 1580 5 - - HYPH cord-014516-r59usk02 1580 6 way way NN cord-014516-r59usk02 1580 7 analysis analysis NN cord-014516-r59usk02 1580 8 of of IN cord-014516-r59usk02 1580 9 variance variance NN cord-014516-r59usk02 1580 10 , , , cord-014516-r59usk02 1580 11 Mann Mann NNP cord-014516-r59usk02 1580 12 - - HYPH cord-014516-r59usk02 1580 13 Whitney Whitney NNP cord-014516-r59usk02 1580 14 U U NNP cord-014516-r59usk02 1580 15 , , , cord-014516-r59usk02 1580 16 and and CC cord-014516-r59usk02 1580 17 Student Student NNP cord-014516-r59usk02 1580 18 's 's POS cord-014516-r59usk02 1580 19 t t NN cord-014516-r59usk02 1580 20 - - HYPH cord-014516-r59usk02 1580 21 test test NN cord-014516-r59usk02 1580 22 ( ( -LRB- cord-014516-r59usk02 1580 23 improvement improvement NN cord-014516-r59usk02 1580 24 of of IN cord-014516-r59usk02 1580 25 clinical clinical JJ cord-014516-r59usk02 1580 26 signs sign NNS cord-014516-r59usk02 1580 27 ) ) -RRB- cord-014516-r59usk02 1580 28 , , , cord-014516-r59usk02 1580 29 Fisher Fisher NNP cord-014516-r59usk02 1580 30 's 's POS cord-014516-r59usk02 1580 31 exact exact JJ cord-014516-r59usk02 1580 32 test test NN cord-014516-r59usk02 1580 33 ( ( -LRB- cord-014516-r59usk02 1580 34 FCV FCV NNP cord-014516-r59usk02 1580 35 shedding shed VBG cord-014516-r59usk02 1580 36 ) ) -RRB- cord-014516-r59usk02 1580 37 , , , cord-014516-r59usk02 1580 38 and and CC cord-014516-r59usk02 1580 39 Spearman Spearman NNP cord-014516-r59usk02 1580 40 analysis analysis NN cord-014516-r59usk02 1580 41 ( ( -LRB- cord-014516-r59usk02 1580 42 correlation correlation NN cord-014516-r59usk02 1580 43 clinical clinical JJ cord-014516-r59usk02 1580 44 signs sign NNS cord-014516-r59usk02 1580 45 with with IN cord-014516-r59usk02 1580 46 virus virus NN cord-014516-r59usk02 1580 47 load load NN cord-014516-r59usk02 1580 48 ) ) -RRB- cord-014516-r59usk02 1580 49 . . . cord-014516-r59usk02 1581 1 Clinical clinical JJ cord-014516-r59usk02 1581 2 signs sign NNS cord-014516-r59usk02 1581 3 and and CC cord-014516-r59usk02 1581 4 general general JJ cord-014516-r59usk02 1581 5 health health NN cord-014516-r59usk02 1581 6 status status NN cord-014516-r59usk02 1581 7 improved improve VBD cord-014516-r59usk02 1581 8 significantly significantly RB cord-014516-r59usk02 1581 9 in in IN cord-014516-r59usk02 1581 10 both both DT cord-014516-r59usk02 1581 11 groups group NNS cord-014516-r59usk02 1581 12 . . . cord-014516-r59usk02 1582 1 However however RB cord-014516-r59usk02 1582 2 , , , cord-014516-r59usk02 1582 3 while while IN cord-014516-r59usk02 1582 4 placebo placebo NN cord-014516-r59usk02 1582 5 - - HYPH cord-014516-r59usk02 1582 6 treated treat VBN cord-014516-r59usk02 1582 7 cats cat NNS cord-014516-r59usk02 1582 8 had have VBD cord-014516-r59usk02 1582 9 only only RB cord-014516-r59usk02 1582 10 improved improve VBN cord-014516-r59usk02 1582 11 significantly significantly RB cord-014516-r59usk02 1582 12 by by IN cord-014516-r59usk02 1582 13 day day NN cord-014516-r59usk02 1582 14 7 7 CD cord-014516-r59usk02 1582 15 , , , cord-014516-r59usk02 1582 16 cats cat NNS cord-014516-r59usk02 1582 17 receiving receive VBG cord-014516-r59usk02 1582 18 antibodies antibody NNS cord-014516-r59usk02 1582 19 already already RB cord-014516-r59usk02 1582 20 significantly significantly RB cord-014516-r59usk02 1582 21 improved improve VBN cord-014516-r59usk02 1582 22 in in IN cord-014516-r59usk02 1582 23 their -PRON- PRP$ cord-014516-r59usk02 1582 24 ' ' `` cord-014516-r59usk02 1582 25 FURTD FURTD NNP cord-014516-r59usk02 1582 26 score score NN cord-014516-r59usk02 1582 27 ' ' '' cord-014516-r59usk02 1582 28 ( ( -LRB- cord-014516-r59usk02 1582 29 P p NN cord-014516-r59usk02 1582 30 = = SYM cord-014516-r59usk02 1582 31 0.046 0.046 CD cord-014516-r59usk02 1582 32 ) ) -RRB- cord-014516-r59usk02 1582 33 and and CC cord-014516-r59usk02 1582 34 general general JJ cord-014516-r59usk02 1582 35 health health NN cord-014516-r59usk02 1582 36 status status NN cord-014516-r59usk02 1582 37 ( ( -LRB- cord-014516-r59usk02 1582 38 P p NN cord-014516-r59usk02 1582 39 = = SYM cord-014516-r59usk02 1582 40 0.032 0.032 CD cord-014516-r59usk02 1582 41 ) ) -RRB- cord-014516-r59usk02 1582 42 by by IN cord-014516-r59usk02 1582 43 day day NN cord-014516-r59usk02 1582 44 3 3 CD cord-014516-r59usk02 1582 45 . . . cord-014516-r59usk02 1583 1 There there EX cord-014516-r59usk02 1583 2 was be VBD cord-014516-r59usk02 1583 3 no no DT cord-014516-r59usk02 1583 4 significant significant JJ cord-014516-r59usk02 1583 5 difference difference NN cord-014516-r59usk02 1583 6 in in IN cord-014516-r59usk02 1583 7 the the DT cord-014516-r59usk02 1583 8 number number NN cord-014516-r59usk02 1583 9 of of IN cord-014516-r59usk02 1583 10 cats cat NNS cord-014516-r59usk02 1583 11 shedding shed VBG cord-014516-r59usk02 1583 12 FCV FCV NNP cord-014516-r59usk02 1583 13 and and CC cord-014516-r59usk02 1583 14 no no DT cord-014516-r59usk02 1583 15 correlation correlation NN cord-014516-r59usk02 1583 16 between between IN cord-014516-r59usk02 1583 17 viral viral JJ cord-014516-r59usk02 1583 18 load load NN cord-014516-r59usk02 1583 19 and and CC cord-014516-r59usk02 1583 20 clinical clinical JJ cord-014516-r59usk02 1583 21 manifestation manifestation NN cord-014516-r59usk02 1583 22 . . . cord-014516-r59usk02 1584 1 Administration administration NN cord-014516-r59usk02 1584 2 of of IN cord-014516-r59usk02 1584 3 antibodies antibody NNS cord-014516-r59usk02 1584 4 lead lead VBP cord-014516-r59usk02 1584 5 to to IN cord-014516-r59usk02 1584 6 faster fast JJR cord-014516-r59usk02 1584 7 improvement improvement NN cord-014516-r59usk02 1584 8 of of IN cord-014516-r59usk02 1584 9 clinical clinical JJ cord-014516-r59usk02 1584 10 signs sign NNS cord-014516-r59usk02 1584 11 in in IN cord-014516-r59usk02 1584 12 cats cat NNS cord-014516-r59usk02 1584 13 with with IN cord-014516-r59usk02 1584 14 acute acute JJ cord-014516-r59usk02 1584 15 viral viral JJ cord-014516-r59usk02 1584 16 FURTD FURTD NNP cord-014516-r59usk02 1584 17 , , , cord-014516-r59usk02 1584 18 but but CC cord-014516-r59usk02 1584 19 did do VBD cord-014516-r59usk02 1584 20 not not RB cord-014516-r59usk02 1584 21 influence influence VB cord-014516-r59usk02 1584 22 FCV FCV NNP cord-014516-r59usk02 1584 23 shedding shed VBG cord-014516-r59usk02 1584 24 . . . cord-014516-r59usk02 1585 1 No no DT cord-014516-r59usk02 1585 2 conflicts conflict NNS cord-014516-r59usk02 1585 3 of of IN cord-014516-r59usk02 1585 4 interest interest NN cord-014516-r59usk02 1585 5 reported report VBN cord-014516-r59usk02 1585 6 . . . cord-014516-r59usk02 1586 1 Different different JJ cord-014516-r59usk02 1586 2 viral viral JJ cord-014516-r59usk02 1586 3 and and CC cord-014516-r59usk02 1586 4 bacterial bacterial JJ cord-014516-r59usk02 1586 5 pathogens pathogen NNS cord-014516-r59usk02 1586 6 can can MD cord-014516-r59usk02 1586 7 be be VB cord-014516-r59usk02 1586 8 involved involve VBN cord-014516-r59usk02 1586 9 in in IN cord-014516-r59usk02 1586 10 feline feline JJ cord-014516-r59usk02 1586 11 upper upper JJ cord-014516-r59usk02 1586 12 respiratory respiratory JJ cord-014516-r59usk02 1586 13 tract tract NN cord-014516-r59usk02 1586 14 disease disease NN cord-014516-r59usk02 1586 15 ( ( -LRB- cord-014516-r59usk02 1586 16 FURTD FURTD NNP cord-014516-r59usk02 1586 17 ) ) -RRB- cord-014516-r59usk02 1586 18 . . . cord-014516-r59usk02 1587 1 Although although IN cord-014516-r59usk02 1587 2 some some DT cord-014516-r59usk02 1587 3 clinical clinical JJ cord-014516-r59usk02 1587 4 signs sign NNS cord-014516-r59usk02 1587 5 have have VBP cord-014516-r59usk02 1587 6 been be VBN cord-014516-r59usk02 1587 7 associated associate VBN cord-014516-r59usk02 1587 8 with with IN cord-014516-r59usk02 1587 9 certain certain JJ cord-014516-r59usk02 1587 10 pathogens pathogen NNS cord-014516-r59usk02 1587 11 , , , cord-014516-r59usk02 1587 12 clinical clinical JJ cord-014516-r59usk02 1587 13 signs sign NNS cord-014516-r59usk02 1587 14 can can MD cord-014516-r59usk02 1587 15 be be VB cord-014516-r59usk02 1587 16 variable variable JJ cord-014516-r59usk02 1587 17 and and CC cord-014516-r59usk02 1587 18 non non JJ cord-014516-r59usk02 1587 19 - - JJ cord-014516-r59usk02 1587 20 specific specific JJ cord-014516-r59usk02 1587 21 . . . cord-014516-r59usk02 1588 1 Aim Aim NNP cord-014516-r59usk02 1588 2 of of IN cord-014516-r59usk02 1588 3 the the DT cord-014516-r59usk02 1588 4 study study NN cord-014516-r59usk02 1588 5 was be VBD cord-014516-r59usk02 1588 6 to to TO cord-014516-r59usk02 1588 7 compare compare VB cord-014516-r59usk02 1588 8 detection detection NN cord-014516-r59usk02 1588 9 rates rate NNS cord-014516-r59usk02 1588 10 of of IN cord-014516-r59usk02 1588 11 feline feline JJ cord-014516-r59usk02 1588 12 herpesvirus-1 herpesvirus-1 NNP cord-014516-r59usk02 1588 13 ( ( -LRB- cord-014516-r59usk02 1588 14 FHV-1 FHV-1 NNP cord-014516-r59usk02 1588 15 ) ) -RRB- cord-014516-r59usk02 1588 16 , , , cord-014516-r59usk02 1588 17 feline feline JJ cord-014516-r59usk02 1588 18 calicivirus calicivirus NNP cord-014516-r59usk02 1588 19 ( ( -LRB- cord-014516-r59usk02 1588 20 FCV),and FCV),and NNP cord-014516-r59usk02 1588 21 Chlamydophila Chlamydophila NNP cord-014516-r59usk02 1588 22 felis felis NN cord-014516-r59usk02 1588 23 ( ( -LRB- cord-014516-r59usk02 1588 24 C. C. NNP cord-014516-r59usk02 1588 25 felis felis NNP cord-014516-r59usk02 1588 26 ) ) -RRB- cord-014516-r59usk02 1588 27 in in IN cord-014516-r59usk02 1588 28 cats cat NNS cord-014516-r59usk02 1588 29 with with IN cord-014516-r59usk02 1588 30 FURTD FURTD NNP cord-014516-r59usk02 1588 31 on on IN cord-014516-r59usk02 1588 32 4 4 CD cord-014516-r59usk02 1588 33 different different JJ cord-014516-r59usk02 1588 34 sampling sampling NN cord-014516-r59usk02 1588 35 sites site NNS cord-014516-r59usk02 1588 36 , , , cord-014516-r59usk02 1588 37 and and CC cord-014516-r59usk02 1588 38 to to TO cord-014516-r59usk02 1588 39 correlate correlate VB cord-014516-r59usk02 1588 40 test test NN cord-014516-r59usk02 1588 41 results result NNS cord-014516-r59usk02 1588 42 and and CC cord-014516-r59usk02 1588 43 clinical clinical JJ cord-014516-r59usk02 1588 44 signs sign NNS cord-014516-r59usk02 1588 45 . . . cord-014516-r59usk02 1589 1 Swabs swab NNS cord-014516-r59usk02 1589 2 of of IN cord-014516-r59usk02 1589 3 nose nose NN cord-014516-r59usk02 1589 4 , , , cord-014516-r59usk02 1589 5 oropharynx oropharynx NN cord-014516-r59usk02 1589 6 , , , cord-014516-r59usk02 1589 7 tongue tongue NN cord-014516-r59usk02 1589 8 , , , cord-014516-r59usk02 1589 9 and and CC cord-014516-r59usk02 1589 10 conjunctiva conjunctiva NN cord-014516-r59usk02 1589 11 were be VBD cord-014516-r59usk02 1589 12 taken take VBN cord-014516-r59usk02 1589 13 from from IN cord-014516-r59usk02 1589 14 104 104 CD cord-014516-r59usk02 1589 15 cats cat NNS cord-014516-r59usk02 1589 16 with with IN cord-014516-r59usk02 1589 17 signs sign NNS cord-014516-r59usk02 1589 18 of of IN cord-014516-r59usk02 1589 19 FURTD FURTD NNP cord-014516-r59usk02 1589 20 . . . cord-014516-r59usk02 1590 1 On on IN cord-014516-r59usk02 1590 2 all all DT cord-014516-r59usk02 1590 3 samples sample NNS cord-014516-r59usk02 1590 4 , , , cord-014516-r59usk02 1590 5 reverse reverse VB cord-014516-r59usk02 1590 6 transcription transcription NN cord-014516-r59usk02 1590 7 polymerase polymerase NN cord-014516-r59usk02 1590 8 chain chain NN cord-014516-r59usk02 1590 9 reaction reaction NN cord-014516-r59usk02 1590 10 ( ( -LRB- cord-014516-r59usk02 1590 11 RT RT NNP cord-014516-r59usk02 1590 12 - - HYPH cord-014516-r59usk02 1590 13 PCR PCR NNP cord-014516-r59usk02 1590 14 ) ) -RRB- cord-014516-r59usk02 1590 15 was be VBD cord-014516-r59usk02 1590 16 performed perform VBN cord-014516-r59usk02 1590 17 for for IN cord-014516-r59usk02 1590 18 detection detection NN cord-014516-r59usk02 1590 19 of of IN cord-014516-r59usk02 1590 20 FCV FCV NNP cord-014516-r59usk02 1590 21 , , , cord-014516-r59usk02 1590 22 and and CC cord-014516-r59usk02 1590 23 polymerase polymerase NN cord-014516-r59usk02 1590 24 chain chain NN cord-014516-r59usk02 1590 25 reaction reaction NN cord-014516-r59usk02 1590 26 ( ( -LRB- cord-014516-r59usk02 1590 27 PCR PCR NNP cord-014516-r59usk02 1590 28 ) ) -RRB- cord-014516-r59usk02 1590 29 for for IN cord-014516-r59usk02 1590 30 detection detection NN cord-014516-r59usk02 1590 31 of of IN cord-014516-r59usk02 1590 32 FHV-1 FHV-1 NNP cord-014516-r59usk02 1590 33 and and CC cord-014516-r59usk02 1590 34 C. C. NNP cord-014516-r59usk02 1590 35 felis felis NNP cord-014516-r59usk02 1590 36 . . . cord-014516-r59usk02 1591 1 Fisher Fisher NNP cord-014516-r59usk02 1591 2 's 's POS cord-014516-r59usk02 1591 3 exact exact JJ cord-014516-r59usk02 1591 4 test test NN cord-014516-r59usk02 1591 5 was be VBD cord-014516-r59usk02 1591 6 used use VBN cord-014516-r59usk02 1591 7 for for IN cord-014516-r59usk02 1591 8 all all DT cord-014516-r59usk02 1591 9 comparisons comparison NNS cord-014516-r59usk02 1591 10 . . . cord-014516-r59usk02 1592 1 The the DT cord-014516-r59usk02 1592 2 level level NN cord-014516-r59usk02 1592 3 of of IN cord-014516-r59usk02 1592 4 significance significance NN cord-014516-r59usk02 1592 5 was be VBD cord-014516-r59usk02 1592 6 p p NN cord-014516-r59usk02 1592 7 < < XX cord-014516-r59usk02 1592 8 0.05 0.05 CD cord-014516-r59usk02 1592 9 . . . cord-014516-r59usk02 1593 1 Pathogens pathogen NNS cord-014516-r59usk02 1593 2 were be VBD cord-014516-r59usk02 1593 3 detected detect VBN cord-014516-r59usk02 1593 4 in in IN cord-014516-r59usk02 1593 5 89.4 89.4 CD cord-014516-r59usk02 1593 6 % % NN cord-014516-r59usk02 1593 7 of of IN cord-014516-r59usk02 1593 8 cats cat NNS cord-014516-r59usk02 1593 9 . . . cord-014516-r59usk02 1594 1 Of of IN cord-014516-r59usk02 1594 2 these these DT cord-014516-r59usk02 1594 3 , , , cord-014516-r59usk02 1594 4 55.8 55.8 CD cord-014516-r59usk02 1594 5 % % NN cord-014516-r59usk02 1594 6 were be VBD cord-014516-r59usk02 1594 7 positive positive JJ cord-014516-r59usk02 1594 8 for for IN cord-014516-r59usk02 1594 9 FHV-1 FHV-1 NNP cord-014516-r59usk02 1594 10 , , , cord-014516-r59usk02 1594 11 50.0 50.0 CD cord-014516-r59usk02 1594 12 % % NN cord-014516-r59usk02 1594 13 for for IN cord-014516-r59usk02 1594 14 FCV FCV NNP cord-014516-r59usk02 1594 15 , , , cord-014516-r59usk02 1594 16 and and CC cord-014516-r59usk02 1594 17 35.6 35.6 CD cord-014516-r59usk02 1594 18 % % NN cord-014516-r59usk02 1594 19 for for IN cord-014516-r59usk02 1594 20 C. C. NNP cord-014516-r59usk02 1594 21 felis felis NNP cord-014516-r59usk02 1594 22 . . . cord-014516-r59usk02 1595 1 FCV FCV NNP cord-014516-r59usk02 1595 2 was be VBD cord-014516-r59usk02 1595 3 isolated isolate VBN cord-014516-r59usk02 1595 4 significantly significantly RB cord-014516-r59usk02 1595 5 more more RBR cord-014516-r59usk02 1595 6 often often RB cord-014516-r59usk02 1595 7 from from IN cord-014516-r59usk02 1595 8 oropharynx oropharynx NN cord-014516-r59usk02 1595 9 ( ( -LRB- cord-014516-r59usk02 1595 10 92.3 92.3 CD cord-014516-r59usk02 1595 11 % % NN cord-014516-r59usk02 1595 12 of of IN cord-014516-r59usk02 1595 13 FCV FCV NNP cord-014516-r59usk02 1595 14 - - HYPH cord-014516-r59usk02 1595 15 positive positive JJ cord-014516-r59usk02 1595 16 cats cat NNS cord-014516-r59usk02 1595 17 ) ) -RRB- cord-014516-r59usk02 1595 18 and and CC cord-014516-r59usk02 1595 19 tongue tongue NN cord-014516-r59usk02 1595 20 ( ( -LRB- cord-014516-r59usk02 1595 21 90.4 90.4 CD cord-014516-r59usk02 1595 22 % % NN cord-014516-r59usk02 1595 23 ) ) -RRB- cord-014516-r59usk02 1595 24 compared compare VBN cord-014516-r59usk02 1595 25 to to IN cord-014516-r59usk02 1595 26 conjunctiva conjunctiva NN cord-014516-r59usk02 1595 27 ( ( -LRB- cord-014516-r59usk02 1595 28 38.5 38.5 CD cord-014516-r59usk02 1595 29 % % NN cord-014516-r59usk02 1595 30 ) ) -RRB- cord-014516-r59usk02 1595 31 ( ( -LRB- cord-014516-r59usk02 1595 32 p p NN cord-014516-r59usk02 1595 33 < < XX cord-014516-r59usk02 1595 34 0.001 0.001 CD cord-014516-r59usk02 1595 35 ) ) -RRB- cord-014516-r59usk02 1595 36 . . . cord-014516-r59usk02 1596 1 There there EX cord-014516-r59usk02 1596 2 was be VBD cord-014516-r59usk02 1596 3 no no DT cord-014516-r59usk02 1596 4 significant significant JJ cord-014516-r59usk02 1596 5 difference difference NN cord-014516-r59usk02 1596 6 between between IN cord-014516-r59usk02 1596 7 the the DT cord-014516-r59usk02 1596 8 4 4 CD cord-014516-r59usk02 1596 9 sampling sampling NN cord-014516-r59usk02 1596 10 sites site NNS cord-014516-r59usk02 1596 11 for for IN cord-014516-r59usk02 1596 12 detection detection NN cord-014516-r59usk02 1596 13 of of IN cord-014516-r59usk02 1596 14 FHV-1 FHV-1 NNP cord-014516-r59usk02 1596 15 and and CC cord-014516-r59usk02 1596 16 C. C. NNP cord-014516-r59usk02 1596 17 felis felis NNP cord-014516-r59usk02 1596 18 . . . cord-014516-r59usk02 1597 1 In in IN cord-014516-r59usk02 1597 2 addition addition NN cord-014516-r59usk02 1597 3 , , , cord-014516-r59usk02 1597 4 there there EX cord-014516-r59usk02 1597 5 was be VBD cord-014516-r59usk02 1597 6 no no DT cord-014516-r59usk02 1597 7 preferred preferred JJ cord-014516-r59usk02 1597 8 sampling sampling NN cord-014516-r59usk02 1597 9 site site NN cord-014516-r59usk02 1597 10 in in IN cord-014516-r59usk02 1597 11 cats cat NNS cord-014516-r59usk02 1597 12 with with IN cord-014516-r59usk02 1597 13 respective respective JJ cord-014516-r59usk02 1597 14 clinical clinical JJ cord-014516-r59usk02 1597 15 signs sign NNS cord-014516-r59usk02 1597 16 , , , cord-014516-r59usk02 1597 17 including include VBG cord-014516-r59usk02 1597 18 oral oral JJ cord-014516-r59usk02 1597 19 ulceration ulceration NN cord-014516-r59usk02 1597 20 , , , cord-014516-r59usk02 1597 21 conjunctivitis conjunctivitis NN cord-014516-r59usk02 1597 22 , , , cord-014516-r59usk02 1597 23 and and CC cord-014516-r59usk02 1597 24 keratitis keratitis NN cord-014516-r59usk02 1597 25 . . . cord-014516-r59usk02 1598 1 In in IN cord-014516-r59usk02 1598 2 cats cat NNS cord-014516-r59usk02 1598 3 with with IN cord-014516-r59usk02 1598 4 FURTD FURTD NNP cord-014516-r59usk02 1598 5 , , , cord-014516-r59usk02 1598 6 the the DT cord-014516-r59usk02 1598 7 oropharynx oropharynx NN cord-014516-r59usk02 1598 8 can can MD cord-014516-r59usk02 1598 9 be be VB cord-014516-r59usk02 1598 10 recommended recommend VBN cord-014516-r59usk02 1598 11 as as IN cord-014516-r59usk02 1598 12 the the DT cord-014516-r59usk02 1598 13 preferred prefer VBN cord-014516-r59usk02 1598 14 sampling sampling NN cord-014516-r59usk02 1598 15 site site NN cord-014516-r59usk02 1598 16 for for IN cord-014516-r59usk02 1598 17 detection detection NN cord-014516-r59usk02 1598 18 of of IN cord-014516-r59usk02 1598 19 FCV FCV NNP cord-014516-r59usk02 1598 20 , , , cord-014516-r59usk02 1598 21 FHV-1 FHV-1 NNP cord-014516-r59usk02 1598 22 , , , cord-014516-r59usk02 1598 23 and and CC cord-014516-r59usk02 1598 24 C. C. NNP cord-014516-r59usk02 1598 25 felis felis NNP cord-014516-r59usk02 1598 26 . . . cord-014516-r59usk02 1599 1 Based base VBN cord-014516-r59usk02 1599 2 upon upon IN cord-014516-r59usk02 1599 3 clinical clinical JJ cord-014516-r59usk02 1599 4 signs sign NNS cord-014516-r59usk02 1599 5 it -PRON- PRP cord-014516-r59usk02 1599 6 can can MD cord-014516-r59usk02 1599 7 not not RB cord-014516-r59usk02 1599 8 be be VB cord-014516-r59usk02 1599 9 determined determine VBN cord-014516-r59usk02 1599 10 which which WDT cord-014516-r59usk02 1599 11 sampling sampling NN cord-014516-r59usk02 1599 12 site site NN cord-014516-r59usk02 1599 13 should should MD cord-014516-r59usk02 1599 14 be be VB cord-014516-r59usk02 1599 15 selected select VBN cord-014516-r59usk02 1599 16 for for IN cord-014516-r59usk02 1599 17 detection detection NN cord-014516-r59usk02 1599 18 of of IN cord-014516-r59usk02 1599 19 the the DT cord-014516-r59usk02 1599 20 pathogens pathogen NNS cord-014516-r59usk02 1599 21 . . . cord-014516-r59usk02 1600 1 No no DT cord-014516-r59usk02 1600 2 conflicts conflict NNS cord-014516-r59usk02 1600 3 of of IN cord-014516-r59usk02 1600 4 interest interest NN cord-014516-r59usk02 1600 5 reported report VBN cord-014516-r59usk02 1600 6 . . . cord-014516-r59usk02 1601 1 PULMONARY PULMONARY NNP cord-014516-r59usk02 1601 2 HAEMORRHAGE HAEMORRHAGE NNP cord-014516-r59usk02 1601 3 SYNDROME syndrome NN cord-014516-r59usk02 1601 4 ( ( -LRB- cord-014516-r59usk02 1601 5 LPHS LPHS NNP cord-014516-r59usk02 1601 6 ) ) -RRB- cord-014516-r59usk02 1601 7 . . . cord-014516-r59usk02 1602 1 S. S. NNP cord-014516-r59usk02 1602 2 Schuller Schuller NNP cord-014516-r59usk02 1602 3 1 1 CD cord-014516-r59usk02 1602 4 , , , cord-014516-r59usk02 1602 5 S. S. NNP cord-014516-r59usk02 1602 6 Callanan Callanan NNP cord-014516-r59usk02 1602 7 2 2 CD cord-014516-r59usk02 1602 8 , , , cord-014516-r59usk02 1602 9 S. S. NNP cord-014516-r59usk02 1602 10 Worrall Worrall NNP cord-014516-r59usk02 1602 11 2 2 CD cord-014516-r59usk02 1602 12 , , , cord-014516-r59usk02 1602 13 T. T. NNP cord-014516-r59usk02 1602 14 Francey Francey NNP cord-014516-r59usk02 1602 15 1 1 CD cord-014516-r59usk02 1602 16 , , , cord-014516-r59usk02 1602 17 A. A. NNP cord-014516-r59usk02 1602 18 Schweighauser Schweighauser NNP cord-014516-r59usk02 1602 19 1 1 CD cord-014516-r59usk02 1602 20 , , , cord-014516-r59usk02 1602 21 J.E. J.E. NNP cord-014516-r59usk02 1602 22 Nally Nally NNP cord-014516-r59usk02 1602 23 2 2 CD cord-014516-r59usk02 1602 24 . . . cord-014516-r59usk02 1603 1 1 1 CD cord-014516-r59usk02 1603 2 Bern Bern NNP cord-014516-r59usk02 1603 3 University University NNP cord-014516-r59usk02 1603 4 , , , cord-014516-r59usk02 1603 5 Bern Bern NNP cord-014516-r59usk02 1603 6 , , , cord-014516-r59usk02 1603 7 Switzerland Switzerland NNP cord-014516-r59usk02 1603 8 , , , cord-014516-r59usk02 1603 9 2 2 CD cord-014516-r59usk02 1603 10 University University NNP cord-014516-r59usk02 1603 11 College College NNP cord-014516-r59usk02 1603 12 Dublin Dublin NNP cord-014516-r59usk02 1603 13 , , , cord-014516-r59usk02 1603 14 Dublin Dublin NNP cord-014516-r59usk02 1603 15 , , , cord-014516-r59usk02 1603 16 Ireland Ireland NNP cord-014516-r59usk02 1603 17 Leptospiral Leptospiral NNP cord-014516-r59usk02 1603 18 Pulmonary Pulmonary NNP cord-014516-r59usk02 1603 19 Haemorrhage Haemorrhage NNP cord-014516-r59usk02 1603 20 Syndrome Syndrome NNP cord-014516-r59usk02 1603 21 ( ( -LRB- cord-014516-r59usk02 1603 22 LPHS LPHS NNP cord-014516-r59usk02 1603 23 ) ) -RRB- cord-014516-r59usk02 1603 24 is be VBZ cord-014516-r59usk02 1603 25 a a DT cord-014516-r59usk02 1603 26 severe severe JJ cord-014516-r59usk02 1603 27 form form NN cord-014516-r59usk02 1603 28 of of IN cord-014516-r59usk02 1603 29 leptospirosis leptospirosis NN cord-014516-r59usk02 1603 30 , , , cord-014516-r59usk02 1603 31 which which WDT cord-014516-r59usk02 1603 32 has have VBZ cord-014516-r59usk02 1603 33 been be VBN cord-014516-r59usk02 1603 34 increasingly increasingly RB cord-014516-r59usk02 1603 35 recognised recognise VBN cord-014516-r59usk02 1603 36 in in IN cord-014516-r59usk02 1603 37 humans human NNS cord-014516-r59usk02 1603 38 and and CC cord-014516-r59usk02 1603 39 many many JJ cord-014516-r59usk02 1603 40 animal animal NN cord-014516-r59usk02 1603 41 species specie NNS cord-014516-r59usk02 1603 42 in in IN cord-014516-r59usk02 1603 43 the the DT cord-014516-r59usk02 1603 44 past past JJ cord-014516-r59usk02 1603 45 20 20 CD cord-014516-r59usk02 1603 46 years year NNS cord-014516-r59usk02 1603 47 . . . cord-014516-r59usk02 1604 1 Patients patient NNS cord-014516-r59usk02 1604 2 with with IN cord-014516-r59usk02 1604 3 LPHS LPHS NNP cord-014516-r59usk02 1604 4 may may MD cord-014516-r59usk02 1604 5 develop develop VB cord-014516-r59usk02 1604 6 rapidly rapidly RB cord-014516-r59usk02 1604 7 progressive progressive JJ cord-014516-r59usk02 1604 8 intra intra JJ cord-014516-r59usk02 1604 9 - - JJ cord-014516-r59usk02 1604 10 alveolar alveolar JJ cord-014516-r59usk02 1604 11 haemorrhage haemorrhage NN cord-014516-r59usk02 1604 12 , , , cord-014516-r59usk02 1604 13 leading lead VBG cord-014516-r59usk02 1604 14 to to IN cord-014516-r59usk02 1604 15 high high JJ cord-014516-r59usk02 1604 16 mortality mortality NN cord-014516-r59usk02 1604 17 . . . cord-014516-r59usk02 1605 1 The the DT cord-014516-r59usk02 1605 2 pathogenic pathogenic JJ cord-014516-r59usk02 1605 3 mechanisms mechanism NNS cord-014516-r59usk02 1605 4 of of IN cord-014516-r59usk02 1605 5 LPHS LPHS NNP cord-014516-r59usk02 1605 6 are be VBP cord-014516-r59usk02 1605 7 poorly poorly RB cord-014516-r59usk02 1605 8 understood understand VBN cord-014516-r59usk02 1605 9 hampering hamper VBG cord-014516-r59usk02 1605 10 the the DT cord-014516-r59usk02 1605 11 application application NN cord-014516-r59usk02 1605 12 of of IN cord-014516-r59usk02 1605 13 effective effective JJ cord-014516-r59usk02 1605 14 treatment treatment NN cord-014516-r59usk02 1605 15 strategies strategy NNS cord-014516-r59usk02 1605 16 . . . cord-014516-r59usk02 1606 1 Studies study NNS cord-014516-r59usk02 1606 2 in in IN cord-014516-r59usk02 1606 3 humans human NNS cord-014516-r59usk02 1606 4 and and CC cord-014516-r59usk02 1606 5 experimentally experimentally RB cord-014516-r59usk02 1606 6 infected infect VBN cord-014516-r59usk02 1606 7 guinea guinea NN cord-014516-r59usk02 1606 8 pigs pig NNS cord-014516-r59usk02 1606 9 have have VBP cord-014516-r59usk02 1606 10 demonstrated demonstrate VBN cord-014516-r59usk02 1606 11 deposition deposition NN cord-014516-r59usk02 1606 12 of of IN cord-014516-r59usk02 1606 13 immunoglobulin immunoglobulin NN cord-014516-r59usk02 1606 14 and and CC cord-014516-r59usk02 1606 15 complement complement VB cord-014516-r59usk02 1606 16 C3 C3 NNP cord-014516-r59usk02 1606 17 in in IN cord-014516-r59usk02 1606 18 LPHS LPHS NNP cord-014516-r59usk02 1606 19 lung lung NN cord-014516-r59usk02 1606 20 tissue tissue NN cord-014516-r59usk02 1606 21 in in IN cord-014516-r59usk02 1606 22 the the DT cord-014516-r59usk02 1606 23 absence absence NN cord-014516-r59usk02 1606 24 of of IN cord-014516-r59usk02 1606 25 significant significant JJ cord-014516-r59usk02 1606 26 numbers number NNS cord-014516-r59usk02 1606 27 of of IN cord-014516-r59usk02 1606 28 leptospires leptospire NNS cord-014516-r59usk02 1606 29 , , , cord-014516-r59usk02 1606 30 suggesting suggest VBG cord-014516-r59usk02 1606 31 that that IN cord-014516-r59usk02 1606 32 LPHS LPHS NNP cord-014516-r59usk02 1606 33 is be VBZ cord-014516-r59usk02 1606 34 , , , cord-014516-r59usk02 1606 35 in in IN cord-014516-r59usk02 1606 36 part part NN cord-014516-r59usk02 1606 37 , , , cord-014516-r59usk02 1606 38 caused cause VBN cord-014516-r59usk02 1606 39 by by IN cord-014516-r59usk02 1606 40 autoimmunity autoimmunity NN cord-014516-r59usk02 1606 41 . . . cord-014516-r59usk02 1607 1 The the DT cord-014516-r59usk02 1607 2 aim aim NN cord-014516-r59usk02 1607 3 of of IN cord-014516-r59usk02 1607 4 this this DT cord-014516-r59usk02 1607 5 project project NN cord-014516-r59usk02 1607 6 was be VBD cord-014516-r59usk02 1607 7 to to TO cord-014516-r59usk02 1607 8 describe describe VB cord-014516-r59usk02 1607 9 the the DT cord-014516-r59usk02 1607 10 histopathologic histopathologic JJ cord-014516-r59usk02 1607 11 features feature NNS cord-014516-r59usk02 1607 12 of of IN cord-014516-r59usk02 1607 13 LPHS LPHS NNP cord-014516-r59usk02 1607 14 in in IN cord-014516-r59usk02 1607 15 dogs dog NNS cord-014516-r59usk02 1607 16 and and CC cord-014516-r59usk02 1607 17 to to TO cord-014516-r59usk02 1607 18 investigate investigate VB cord-014516-r59usk02 1607 19 whether whether IN cord-014516-r59usk02 1607 20 IgG IgG NNP cord-014516-r59usk02 1607 21 and and CC cord-014516-r59usk02 1607 22 IgM IgM NNP cord-014516-r59usk02 1607 23 deposition deposition NNP cord-014516-r59usk02 1607 24 is be VBZ cord-014516-r59usk02 1607 25 present present JJ cord-014516-r59usk02 1607 26 in in IN cord-014516-r59usk02 1607 27 affected affect VBN cord-014516-r59usk02 1607 28 canine canine JJ cord-014516-r59usk02 1607 29 lung lung NN cord-014516-r59usk02 1607 30 tissue tissue NN cord-014516-r59usk02 1607 31 . . . cord-014516-r59usk02 1608 1 Single single JJ cord-014516-r59usk02 1608 2 - - HYPH cord-014516-r59usk02 1608 3 step step NN cord-014516-r59usk02 1608 4 immunohistochemistry immunohistochemistry NN cord-014516-r59usk02 1608 5 ( ( -LRB- cord-014516-r59usk02 1608 6 IHC IHC NNP cord-014516-r59usk02 1608 7 ) ) -RRB- cord-014516-r59usk02 1608 8 for for IN cord-014516-r59usk02 1608 9 dog dog NNP cord-014516-r59usk02 1608 10 IgG IgG NNP cord-014516-r59usk02 1608 11 , , , cord-014516-r59usk02 1608 12 IgM IgM NNP cord-014516-r59usk02 1608 13 and and CC cord-014516-r59usk02 1608 14 leptospiral leptospiral NNP cord-014516-r59usk02 1608 15 outer outer JJ cord-014516-r59usk02 1608 16 membrane membrane NN cord-014516-r59usk02 1608 17 vesicles vesicle NNS cord-014516-r59usk02 1608 18 was be VBD cord-014516-r59usk02 1608 19 performed perform VBN cord-014516-r59usk02 1608 20 on on IN cord-014516-r59usk02 1608 21 lung lung NN cord-014516-r59usk02 1608 22 tissues tissue NNS cord-014516-r59usk02 1608 23 from from IN cord-014516-r59usk02 1608 24 11 11 CD cord-014516-r59usk02 1608 25 dogs dog NNS cord-014516-r59usk02 1608 26 with with IN cord-014516-r59usk02 1608 27 LPHS LPHS NNP cord-014516-r59usk02 1608 28 , , , cord-014516-r59usk02 1608 29 4 4 CD cord-014516-r59usk02 1608 30 dogs dog NNS cord-014516-r59usk02 1608 31 with with IN cord-014516-r59usk02 1608 32 pulmonary pulmonary JJ cord-014516-r59usk02 1608 33 haemorrhage haemorrhage NN cord-014516-r59usk02 1608 34 due due IN cord-014516-r59usk02 1608 35 to to IN cord-014516-r59usk02 1608 36 other other JJ cord-014516-r59usk02 1608 37 causes cause NNS cord-014516-r59usk02 1608 38 and and CC cord-014516-r59usk02 1608 39 4 4 CD cord-014516-r59usk02 1608 40 healthy healthy JJ cord-014516-r59usk02 1608 41 dog dog NN cord-014516-r59usk02 1608 42 lungs lung NNS cord-014516-r59usk02 1608 43 . . . cord-014516-r59usk02 1609 1 Acute acute JJ cord-014516-r59usk02 1609 2 intra intra JJ cord-014516-r59usk02 1609 3 - - JJ cord-014516-r59usk02 1609 4 alveolar alveolar JJ cord-014516-r59usk02 1609 5 haemorrhage haemorrhage NN cord-014516-r59usk02 1609 6 and and CC cord-014516-r59usk02 1609 7 oedema oedema NN cord-014516-r59usk02 1609 8 in in IN cord-014516-r59usk02 1609 9 the the DT cord-014516-r59usk02 1609 10 absence absence NN cord-014516-r59usk02 1609 11 of of IN cord-014516-r59usk02 1609 12 significant significant JJ cord-014516-r59usk02 1609 13 inflammatory inflammatory JJ cord-014516-r59usk02 1609 14 infiltrates infiltrate NNS cord-014516-r59usk02 1609 15 were be VBD cord-014516-r59usk02 1609 16 present present JJ cord-014516-r59usk02 1609 17 in in IN cord-014516-r59usk02 1609 18 all all DT cord-014516-r59usk02 1609 19 LPHS LPHS NNP cord-014516-r59usk02 1609 20 lung lung NN cord-014516-r59usk02 1609 21 tissues tissue NNS cord-014516-r59usk02 1609 22 . . . cord-014516-r59usk02 1610 1 Three three CD cord-014516-r59usk02 1610 2 IHC IHC NNP cord-014516-r59usk02 1610 3 staining staining NN cord-014516-r59usk02 1610 4 patterns pattern NNS cord-014516-r59usk02 1610 5 were be VBD cord-014516-r59usk02 1610 6 observed observe VBN cord-014516-r59usk02 1610 7 in in IN cord-014516-r59usk02 1610 8 LPHS LPHS NNP cord-014516-r59usk02 1610 9 lung lung NN cord-014516-r59usk02 1610 10 tissue tissue NN cord-014516-r59usk02 1610 11 : : : cord-014516-r59usk02 1610 12 alveolar alveolar JJ cord-014516-r59usk02 1610 13 septal septal JJ cord-014516-r59usk02 1610 14 wall wall NN cord-014516-r59usk02 1610 15 staining stain VBG cord-014516-r59usk02 1610 16 with with IN cord-014516-r59usk02 1610 17 ( ( -LRB- cord-014516-r59usk02 1610 18 IgG IgG NNP cord-014516-r59usk02 1610 19 n n NNP cord-014516-r59usk02 1610 20 = = SYM cord-014516-r59usk02 1610 21 8 8 CD cord-014516-r59usk02 1611 1 /IgM /IgM NFP cord-014516-r59usk02 1611 2 n n NN cord-014516-r59usk02 1611 3 = = SYM cord-014516-r59usk02 1611 4 6 6 CD cord-014516-r59usk02 1611 5 ) ) -RRB- cord-014516-r59usk02 1612 1 and and CC cord-014516-r59usk02 1612 2 without without IN cord-014516-r59usk02 1612 3 intra intra JJ cord-014516-r59usk02 1612 4 - - JJ cord-014516-r59usk02 1612 5 alveolar alveolar JJ cord-014516-r59usk02 1612 6 staining staining NN cord-014516-r59usk02 1612 7 ( ( -LRB- cord-014516-r59usk02 1612 8 IgG IgG NNP cord-014516-r59usk02 1612 9 n n NNP cord-014516-r59usk02 1612 10 = = SYM cord-014516-r59usk02 1612 11 2 2 CD cord-014516-r59usk02 1612 12 / / SYM cord-014516-r59usk02 1612 13 IgM IgM NNP cord-014516-r59usk02 1612 14 n n NNP cord-014516-r59usk02 1612 15 = = SYM cord-014516-r59usk02 1612 16 0 0 NFP cord-014516-r59usk02 1612 17 ) ) -RRB- cord-014516-r59usk02 1612 18 and and CC cord-014516-r59usk02 1612 19 staining staining NN cord-014516-r59usk02 1612 20 of of IN cord-014516-r59usk02 1612 21 intra intra JJ cord-014516-r59usk02 1612 22 - - JJ cord-014516-r59usk02 1612 23 alveolar alveolar JJ cord-014516-r59usk02 1612 24 fluid fluid NN cord-014516-r59usk02 1612 25 only only RB cord-014516-r59usk02 1612 26 ( ( -LRB- cord-014516-r59usk02 1612 27 IgG IgG NNP cord-014516-r59usk02 1612 28 n n NNP cord-014516-r59usk02 1612 29 = = SYM cord-014516-r59usk02 1612 30 1 1 CD cord-014516-r59usk02 1612 31 / / SYM cord-014516-r59usk02 1612 32 IgM IgM NNP cord-014516-r59usk02 1612 33 n n NNP cord-014516-r59usk02 1612 34 = = SYM cord-014516-r59usk02 1612 35 5 5 CD cord-014516-r59usk02 1612 36 ) ) -RRB- cord-014516-r59usk02 1612 37 . . . cord-014516-r59usk02 1613 1 Intra intra JJ cord-014516-r59usk02 1613 2 - - JJ cord-014516-r59usk02 1613 3 alveolar alveolar JJ cord-014516-r59usk02 1613 4 staining staining NN cord-014516-r59usk02 1613 5 appeared appear VBD cord-014516-r59usk02 1613 6 to to TO cord-014516-r59usk02 1613 7 favour favour VB cord-014516-r59usk02 1613 8 alveolar alveolar NN cord-014516-r59usk02 1613 9 surfaces surface NNS cord-014516-r59usk02 1613 10 in in IN cord-014516-r59usk02 1613 11 some some DT cord-014516-r59usk02 1613 12 cases case NNS cord-014516-r59usk02 1614 1 ( ( -LRB- cord-014516-r59usk02 1614 2 IgG IgG NNP cord-014516-r59usk02 1614 3 n n NNP cord-014516-r59usk02 1614 4 = = SYM cord-014516-r59usk02 1614 5 5 5 CD cord-014516-r59usk02 1614 6 / / SYM cord-014516-r59usk02 1614 7 IgM IgM NNP cord-014516-r59usk02 1614 8 n n NNP cord-014516-r59usk02 1614 9 = = SYM cord-014516-r59usk02 1614 10 5 5 CD cord-014516-r59usk02 1614 11 ) ) -RRB- cord-014516-r59usk02 1614 12 . . . cord-014516-r59usk02 1615 1 Healthy healthy JJ cord-014516-r59usk02 1615 2 control control NN cord-014516-r59usk02 1615 3 lungs lung NNS cord-014516-r59usk02 1615 4 showed show VBD cord-014516-r59usk02 1615 5 no no DT cord-014516-r59usk02 1615 6 staining staining NN cord-014516-r59usk02 1615 7 , , , cord-014516-r59usk02 1615 8 whereas whereas IN cord-014516-r59usk02 1615 9 haemorrhagic haemorrhagic JJ cord-014516-r59usk02 1615 10 lung lung NN cord-014516-r59usk02 1615 11 showed show VBD cord-014516-r59usk02 1615 12 staining staining NN cord-014516-r59usk02 1615 13 of of IN cord-014516-r59usk02 1615 14 intraalveolar intraalveolar NNP cord-014516-r59usk02 1615 15 fluid fluid NNP cord-014516-r59usk02 1615 16 ( ( -LRB- cord-014516-r59usk02 1615 17 IgG IgG NNP cord-014516-r59usk02 1615 18 / / SYM cord-014516-r59usk02 1615 19 IgM IgM NNP cord-014516-r59usk02 1615 20 n n NNP cord-014516-r59usk02 1615 21 = = SYM cord-014516-r59usk02 1615 22 3 3 CD cord-014516-r59usk02 1615 23 ) ) -RRB- cord-014516-r59usk02 1615 24 ) ) -RRB- cord-014516-r59usk02 1615 25 and and CC cord-014516-r59usk02 1615 26 occasional occasional JJ cord-014516-r59usk02 1615 27 , , , cord-014516-r59usk02 1615 28 mild mild JJ cord-014516-r59usk02 1615 29 and and CC cord-014516-r59usk02 1615 30 discontinuous discontinuous JJ cord-014516-r59usk02 1615 31 staining staining NN cord-014516-r59usk02 1615 32 of of IN cord-014516-r59usk02 1615 33 alveolar alveolar JJ cord-014516-r59usk02 1615 34 septa septa NNP cord-014516-r59usk02 1615 35 ( ( -LRB- cord-014516-r59usk02 1615 36 n n NN cord-014516-r59usk02 1615 37 = = SYM cord-014516-r59usk02 1615 38 1 1 CD cord-014516-r59usk02 1615 39 ) ) -RRB- cord-014516-r59usk02 1615 40 . . . cord-014516-r59usk02 1616 1 Leptospiral leptospiral JJ cord-014516-r59usk02 1616 2 antigens antigen NNS cord-014516-r59usk02 1616 3 were be VBD cord-014516-r59usk02 1616 4 not not RB cord-014516-r59usk02 1616 5 detected detect VBN cord-014516-r59usk02 1616 6 in in IN cord-014516-r59usk02 1616 7 any any DT cord-014516-r59usk02 1616 8 of of IN cord-014516-r59usk02 1616 9 the the DT cord-014516-r59usk02 1616 10 tissues tissue NNS cord-014516-r59usk02 1616 11 . . . cord-014516-r59usk02 1617 1 Results result NNS cord-014516-r59usk02 1617 2 indicate indicate VBP cord-014516-r59usk02 1617 3 that that IN cord-014516-r59usk02 1617 4 histopathologic histopathologic JJ cord-014516-r59usk02 1617 5 features feature NNS cord-014516-r59usk02 1617 6 of of IN cord-014516-r59usk02 1617 7 canine canine JJ cord-014516-r59usk02 1617 8 LPHS LPHS NNP cord-014516-r59usk02 1617 9 are be VBP cord-014516-r59usk02 1617 10 similar similar JJ cord-014516-r59usk02 1617 11 to to IN cord-014516-r59usk02 1617 12 what what WP cord-014516-r59usk02 1617 13 has have VBZ cord-014516-r59usk02 1617 14 been be VBN cord-014516-r59usk02 1617 15 described describe VBN cord-014516-r59usk02 1617 16 in in IN cord-014516-r59usk02 1617 17 other other JJ cord-014516-r59usk02 1617 18 species specie NNS cord-014516-r59usk02 1617 19 . . . cord-014516-r59usk02 1618 1 IHC IHC NNP cord-014516-r59usk02 1618 2 demonstrated demonstrate VBD cord-014516-r59usk02 1618 3 that that IN cord-014516-r59usk02 1618 4 alveolar alveolar JJ cord-014516-r59usk02 1618 5 septal septal JJ cord-014516-r59usk02 1618 6 deposition deposition NN cord-014516-r59usk02 1618 7 of of IN cord-014516-r59usk02 1618 8 IgG IgG NNP cord-014516-r59usk02 1618 9 / / SYM cord-014516-r59usk02 1618 10 IgM IgM NNP cord-014516-r59usk02 1618 11 is be VBZ cord-014516-r59usk02 1618 12 present present JJ cord-014516-r59usk02 1618 13 in in IN cord-014516-r59usk02 1618 14 most most JJS cord-014516-r59usk02 1618 15 dogs dog NNS cord-014516-r59usk02 1618 16 with with IN cord-014516-r59usk02 1618 17 naturally naturally RB cord-014516-r59usk02 1618 18 occurring occur VBG cord-014516-r59usk02 1618 19 LPHS LPHS NNP cord-014516-r59usk02 1618 20 . . . cord-014516-r59usk02 1619 1 While while IN cord-014516-r59usk02 1619 2 these these DT cord-014516-r59usk02 1619 3 findings finding NNS cord-014516-r59usk02 1619 4 support support VBP cord-014516-r59usk02 1619 5 a a DT cord-014516-r59usk02 1619 6 role role NN cord-014516-r59usk02 1619 7 of of IN cord-014516-r59usk02 1619 8 the the DT cord-014516-r59usk02 1619 9 humoral humoral JJ cord-014516-r59usk02 1619 10 immune immune JJ cord-014516-r59usk02 1619 11 response response NN cord-014516-r59usk02 1619 12 in in IN cord-014516-r59usk02 1619 13 the the DT cord-014516-r59usk02 1619 14 development development NN cord-014516-r59usk02 1619 15 of of IN cord-014516-r59usk02 1619 16 LPHS LPHS NNP cord-014516-r59usk02 1619 17 , , , cord-014516-r59usk02 1619 18 our -PRON- PRP$ cord-014516-r59usk02 1619 19 findings finding NNS cord-014516-r59usk02 1619 20 do do VBP cord-014516-r59usk02 1619 21 not not RB cord-014516-r59usk02 1619 22 indicate indicate VB cord-014516-r59usk02 1619 23 whether whether IN cord-014516-r59usk02 1619 24 autoimmunity autoimmunity NN cord-014516-r59usk02 1619 25 is be VBZ cord-014516-r59usk02 1619 26 a a DT cord-014516-r59usk02 1619 27 primary primary JJ cord-014516-r59usk02 1619 28 or or CC cord-014516-r59usk02 1619 29 secondary secondary JJ cord-014516-r59usk02 1619 30 event event NN cord-014516-r59usk02 1619 31 in in IN cord-014516-r59usk02 1619 32 the the DT cord-014516-r59usk02 1619 33 pathogenesis pathogenesis NN cord-014516-r59usk02 1619 34 of of IN cord-014516-r59usk02 1619 35 LPHS LPHS NNP cord-014516-r59usk02 1619 36 . . . cord-014516-r59usk02 1620 1 No no DT cord-014516-r59usk02 1620 2 conflicts conflict NNS cord-014516-r59usk02 1620 3 of of IN cord-014516-r59usk02 1620 4 interest interest NN cord-014516-r59usk02 1620 5 reported report VBN cord-014516-r59usk02 1620 6 . . . cord-014516-r59usk02 1621 1 Leptospirosis leptospirosis NN cord-014516-r59usk02 1621 2 , , , cord-014516-r59usk02 1621 3 a a DT cord-014516-r59usk02 1621 4 zoonotic zoonotic JJ cord-014516-r59usk02 1621 5 bacterial bacterial JJ cord-014516-r59usk02 1621 6 disease disease NN cord-014516-r59usk02 1621 7 with with IN cord-014516-r59usk02 1621 8 a a DT cord-014516-r59usk02 1621 9 worldwide worldwide JJ cord-014516-r59usk02 1621 10 distribution distribution NN cord-014516-r59usk02 1621 11 , , , cord-014516-r59usk02 1621 12 is be VBZ cord-014516-r59usk02 1621 13 a a DT cord-014516-r59usk02 1621 14 re re JJ cord-014516-r59usk02 1621 15 - - JJ cord-014516-r59usk02 1621 16 emerging emerge VBG cord-014516-r59usk02 1621 17 disease disease NN cord-014516-r59usk02 1621 18 in in IN cord-014516-r59usk02 1621 19 humans human NNS cord-014516-r59usk02 1621 20 and and CC cord-014516-r59usk02 1621 21 dogs dog NNS cord-014516-r59usk02 1621 22 . . . cord-014516-r59usk02 1622 1 Acute acute JJ cord-014516-r59usk02 1622 2 renal renal JJ cord-014516-r59usk02 1622 3 and and CC cord-014516-r59usk02 1622 4 hepatic hepatic JJ cord-014516-r59usk02 1622 5 failure failure NN cord-014516-r59usk02 1622 6 are be VBP cord-014516-r59usk02 1622 7 the the DT cord-014516-r59usk02 1622 8 most most RBS cord-014516-r59usk02 1622 9 frequently frequently RB cord-014516-r59usk02 1622 10 reported report VBD cord-014516-r59usk02 1622 11 clinical clinical JJ cord-014516-r59usk02 1622 12 manifestations manifestation NNS cord-014516-r59usk02 1622 13 of of IN cord-014516-r59usk02 1622 14 canine canine JJ cord-014516-r59usk02 1622 15 leptospirosis leptospirosis NN cord-014516-r59usk02 1622 16 . . . cord-014516-r59usk02 1623 1 The the DT cord-014516-r59usk02 1623 2 aim aim NN cord-014516-r59usk02 1623 3 of of IN cord-014516-r59usk02 1623 4 this this DT cord-014516-r59usk02 1623 5 study study NN cord-014516-r59usk02 1623 6 was be VBD cord-014516-r59usk02 1623 7 to to TO cord-014516-r59usk02 1623 8 describe describe VB cord-014516-r59usk02 1623 9 clinical clinical JJ cord-014516-r59usk02 1623 10 , , , cord-014516-r59usk02 1623 11 laboratory laboratory NN cord-014516-r59usk02 1623 12 and and CC cord-014516-r59usk02 1623 13 radiological radiological JJ cord-014516-r59usk02 1623 14 features feature NNS cord-014516-r59usk02 1623 15 , , , cord-014516-r59usk02 1623 16 the the DT cord-014516-r59usk02 1623 17 outcome outcome NN cord-014516-r59usk02 1623 18 as as RB cord-014516-r59usk02 1623 19 well well RB cord-014516-r59usk02 1623 20 as as IN cord-014516-r59usk02 1623 21 the the DT cord-014516-r59usk02 1623 22 distribution distribution NN cord-014516-r59usk02 1623 23 of of IN cord-014516-r59usk02 1623 24 Leptospira Leptospira NNP cord-014516-r59usk02 1623 25 serogroups serogroup NNS cord-014516-r59usk02 1623 26 in in IN cord-014516-r59usk02 1623 27 dogs dog NNS cord-014516-r59usk02 1623 28 with with IN cord-014516-r59usk02 1623 29 leptospirosis leptospirosis NN cord-014516-r59usk02 1623 30 ( ( -LRB- cord-014516-r59usk02 1623 31 2006 2006 CD cord-014516-r59usk02 1623 32 ) ) -RRB- cord-014516-r59usk02 1623 33 ( ( -LRB- cord-014516-r59usk02 1623 34 2007 2007 CD cord-014516-r59usk02 1623 35 ) ) -RRB- cord-014516-r59usk02 1624 1 ( ( -LRB- cord-014516-r59usk02 1624 2 2008 2008 CD cord-014516-r59usk02 1624 3 ) ) -RRB- cord-014516-r59usk02 1625 1 ( ( -LRB- cord-014516-r59usk02 1625 2 2009 2009 CD cord-014516-r59usk02 1625 3 ) ) -RRB- cord-014516-r59usk02 1626 1 ( ( -LRB- cord-014516-r59usk02 1626 2 2010 2010 CD cord-014516-r59usk02 1626 3 ) ) -RRB- cord-014516-r59usk02 1627 1 ( ( -LRB- cord-014516-r59usk02 1627 2 2011 2011 CD cord-014516-r59usk02 1627 3 ) ) -RRB- cord-014516-r59usk02 1628 1 ( ( -LRB- cord-014516-r59usk02 1628 2 2012 2012 CD cord-014516-r59usk02 1628 3 ) ) -RRB- cord-014516-r59usk02 1628 4 ( ( -LRB- cord-014516-r59usk02 1628 5 2013 2013 CD cord-014516-r59usk02 1628 6 ) ) -RRB- cord-014516-r59usk02 1628 7 . . . cord-014516-r59usk02 1629 1 Medical medical JJ cord-014516-r59usk02 1629 2 records record NNS cord-014516-r59usk02 1629 3 of of IN cord-014516-r59usk02 1629 4 dogs dog NNS cord-014516-r59usk02 1629 5 diagnosed diagnose VBN cord-014516-r59usk02 1629 6 with with IN cord-014516-r59usk02 1629 7 leptospirosis leptospirosis NN cord-014516-r59usk02 1629 8 were be VBD cord-014516-r59usk02 1629 9 evaluated evaluate VBN cord-014516-r59usk02 1629 10 retrospectively retrospectively RB cord-014516-r59usk02 1629 11 . . . cord-014516-r59usk02 1630 1 Diagnoses diagnosis NNS cord-014516-r59usk02 1630 2 were be VBD cord-014516-r59usk02 1630 3 based base VBN cord-014516-r59usk02 1630 4 on on IN cord-014516-r59usk02 1630 5 microscopic microscopic JJ cord-014516-r59usk02 1630 6 agglutination agglutination NN cord-014516-r59usk02 1630 7 testing testing NN cord-014516-r59usk02 1630 8 ( ( -LRB- cord-014516-r59usk02 1630 9 MAT MAT NNP cord-014516-r59usk02 1630 10 ) ) -RRB- cord-014516-r59usk02 1630 11 , , , cord-014516-r59usk02 1630 12 blood blood NN cord-014516-r59usk02 1630 13 / / SYM cord-014516-r59usk02 1630 14 urine urine NN cord-014516-r59usk02 1630 15 PCR PCR NNP cord-014516-r59usk02 1630 16 , , , cord-014516-r59usk02 1630 17 and and CC cord-014516-r59usk02 1630 18 histopathology histopathology NN cord-014516-r59usk02 1630 19 ( ( -LRB- cord-014516-r59usk02 1630 20 Levaditi Levaditi NNP cord-014516-r59usk02 1630 21 staining stain VBG cord-014516-r59usk02 1630 22 ) ) -RRB- cord-014516-r59usk02 1630 23 . . . cord-014516-r59usk02 1631 1 MAT mat NN cord-014516-r59usk02 1631 2 - - HYPH cord-014516-r59usk02 1631 3 titers titer NNS cord-014516-r59usk02 1631 4 ≥ ≥ CD cord-014516-r59usk02 1631 5 1:800 1:800 CD cord-014516-r59usk02 1631 6 against against IN cord-014516-r59usk02 1631 7 non non JJ cord-014516-r59usk02 1631 8 - - JJ cord-014516-r59usk02 1631 9 vaccine vaccine JJ cord-014516-r59usk02 1631 10 and and CC cord-014516-r59usk02 1631 11 ≥ ≥ CD cord-014516-r59usk02 1631 12 1:3200 1:3200 CD cord-014516-r59usk02 1631 13 against against IN cord-014516-r59usk02 1631 14 vaccine vaccine NN cord-014516-r59usk02 1631 15 serovars serovar NNS cord-014516-r59usk02 1631 16 or or CC cord-014516-r59usk02 1631 17 a a DT cord-014516-r59usk02 1631 18 4-fold 4-fold CD cord-014516-r59usk02 1631 19 rise rise NN cord-014516-r59usk02 1631 20 of of IN cord-014516-r59usk02 1631 21 titers titer NNS cord-014516-r59usk02 1631 22 within within IN cord-014516-r59usk02 1631 23 2 2 CD cord-014516-r59usk02 1631 24 - - SYM cord-014516-r59usk02 1631 25 3 3 CD cord-014516-r59usk02 1631 26 weeks week NNS cord-014516-r59usk02 1631 27 were be VBD cord-014516-r59usk02 1631 28 considered consider VBN cord-014516-r59usk02 1631 29 diagnostic diagnostic JJ cord-014516-r59usk02 1631 30 . . . cord-014516-r59usk02 1632 1 99 99 CD cord-014516-r59usk02 1632 2 dogs dog NNS cord-014516-r59usk02 1632 3 met meet VBD cord-014516-r59usk02 1632 4 the the DT cord-014516-r59usk02 1632 5 inclusion inclusion NN cord-014516-r59usk02 1632 6 criteria criterion NNS cord-014516-r59usk02 1632 7 . . . cord-014516-r59usk02 1633 1 In in IN cord-014516-r59usk02 1633 2 72 72 CD cord-014516-r59usk02 1633 3 dogs dog NNS cord-014516-r59usk02 1633 4 diagnostic diagnostic JJ cord-014516-r59usk02 1633 5 MAT mat NN cord-014516-r59usk02 1633 6 - - HYPH cord-014516-r59usk02 1633 7 titers titer NNS cord-014516-r59usk02 1633 8 were be VBD cord-014516-r59usk02 1633 9 present present JJ cord-014516-r59usk02 1633 10 ( ( -LRB- cord-014516-r59usk02 1633 11 mainly mainly RB cord-014516-r59usk02 1633 12 against against IN cord-014516-r59usk02 1633 13 serogroups serogroup NNS cord-014516-r59usk02 1633 14 Grippotyphosa Grippotyphosa NNP cord-014516-r59usk02 1633 15 ( ( -LRB- cord-014516-r59usk02 1633 16 65 65 CD cord-014516-r59usk02 1633 17 % % NN cord-014516-r59usk02 1633 18 ) ) -RRB- cord-014516-r59usk02 1633 19 , , , cord-014516-r59usk02 1633 20 Australis Australis NNP cord-014516-r59usk02 1633 21 ( ( -LRB- cord-014516-r59usk02 1633 22 61 61 CD cord-014516-r59usk02 1633 23 % % NN cord-014516-r59usk02 1633 24 ) ) -RRB- cord-014516-r59usk02 1633 25 , , , cord-014516-r59usk02 1633 26 and and CC cord-014516-r59usk02 1633 27 Pomona Pomona NNP cord-014516-r59usk02 1633 28 ( ( -LRB- cord-014516-r59usk02 1633 29 60 60 CD cord-014516-r59usk02 1633 30 % % NN cord-014516-r59usk02 1633 31 ) ) -RRB- cord-014516-r59usk02 1633 32 . . . cord-014516-r59usk02 1634 1 At at IN cord-014516-r59usk02 1634 2 initial initial JJ cord-014516-r59usk02 1634 3 presentation presentation NN cord-014516-r59usk02 1634 4 , , , cord-014516-r59usk02 1634 5 the the DT cord-014516-r59usk02 1634 6 most most RBS cord-014516-r59usk02 1634 7 common common JJ cord-014516-r59usk02 1634 8 clinical clinical JJ cord-014516-r59usk02 1634 9 signs sign NNS cord-014516-r59usk02 1634 10 were be VBD cord-014516-r59usk02 1634 11 lethargy lethargy NN cord-014516-r59usk02 1634 12 ( ( -LRB- cord-014516-r59usk02 1634 13 96 96 CD cord-014516-r59usk02 1634 14 % % NN cord-014516-r59usk02 1634 15 ) ) -RRB- cord-014516-r59usk02 1634 16 , , , cord-014516-r59usk02 1634 17 anorexia anorexia NN cord-014516-r59usk02 1634 18 ( ( -LRB- cord-014516-r59usk02 1634 19 88 88 CD cord-014516-r59usk02 1634 20 % % NN cord-014516-r59usk02 1634 21 ) ) -RRB- cord-014516-r59usk02 1634 22 , , , cord-014516-r59usk02 1634 23 vomitus vomitus NN cord-014516-r59usk02 1634 24 ( ( -LRB- cord-014516-r59usk02 1634 25 85 85 CD cord-014516-r59usk02 1634 26 % % NN cord-014516-r59usk02 1634 27 ) ) -RRB- cord-014516-r59usk02 1634 28 , , , cord-014516-r59usk02 1634 29 a a DT cord-014516-r59usk02 1634 30 painful painful JJ cord-014516-r59usk02 1634 31 abdomen abdomen NN cord-014516-r59usk02 1634 32 ( ( -LRB- cord-014516-r59usk02 1634 33 39 39 CD cord-014516-r59usk02 1634 34 % % NN cord-014516-r59usk02 1634 35 ) ) -RRB- cord-014516-r59usk02 1634 36 , , , cord-014516-r59usk02 1634 37 diarrhea diarrhea NN cord-014516-r59usk02 1634 38 ( ( -LRB- cord-014516-r59usk02 1634 39 38 38 CD cord-014516-r59usk02 1634 40 % % NN cord-014516-r59usk02 1634 41 ) ) -RRB- cord-014516-r59usk02 1634 42 , , , cord-014516-r59usk02 1634 43 oliguria oliguria FW cord-014516-r59usk02 1634 44 ( ( -LRB- cord-014516-r59usk02 1634 45 27 27 CD cord-014516-r59usk02 1634 46 % % NN cord-014516-r59usk02 1634 47 ) ) -RRB- cord-014516-r59usk02 1634 48 , , , cord-014516-r59usk02 1634 49 tachypnea tachypnea NNP cord-014516-r59usk02 1634 50 ( ( -LRB- cord-014516-r59usk02 1634 51 26 26 CD cord-014516-r59usk02 1634 52 % % NN cord-014516-r59usk02 1634 53 ) ) -RRB- cord-014516-r59usk02 1634 54 , , , cord-014516-r59usk02 1634 55 delayed delay VBN cord-014516-r59usk02 1634 56 capillary capillary JJ cord-014516-r59usk02 1634 57 refill refill NN cord-014516-r59usk02 1634 58 time time NN cord-014516-r59usk02 1634 59 ( ( -LRB- cord-014516-r59usk02 1634 60 18 18 CD cord-014516-r59usk02 1634 61 % % NN cord-014516-r59usk02 1634 62 ) ) -RRB- cord-014516-r59usk02 1634 63 , , , cord-014516-r59usk02 1634 64 pale pale JJ cord-014516-r59usk02 1634 65 mucous mucous JJ cord-014516-r59usk02 1634 66 membranes membrane NNS cord-014516-r59usk02 1634 67 ( ( -LRB- cord-014516-r59usk02 1634 68 17 17 CD cord-014516-r59usk02 1634 69 % % NN cord-014516-r59usk02 1634 70 ) ) -RRB- cord-014516-r59usk02 1634 71 , , , cord-014516-r59usk02 1634 72 fever fever NN cord-014516-r59usk02 1634 73 ( ( -LRB- cord-014516-r59usk02 1634 74 15 15 CD cord-014516-r59usk02 1634 75 % % NN cord-014516-r59usk02 1634 76 ) ) -RRB- cord-014516-r59usk02 1634 77 , , , cord-014516-r59usk02 1634 78 hypothermia hypothermia NN cord-014516-r59usk02 1634 79 ( ( -LRB- cord-014516-r59usk02 1634 80 15 15 CD cord-014516-r59usk02 1634 81 % % NN cord-014516-r59usk02 1634 82 ) ) -RRB- cord-014516-r59usk02 1634 83 , , , cord-014516-r59usk02 1634 84 and and CC cord-014516-r59usk02 1634 85 icteric icteric JJ cord-014516-r59usk02 1634 86 mucous mucous JJ cord-014516-r59usk02 1634 87 membranes membrane NNS cord-014516-r59usk02 1634 88 ( ( -LRB- cord-014516-r59usk02 1634 89 10 10 CD cord-014516-r59usk02 1634 90 % % NN cord-014516-r59usk02 1634 91 ) ) -RRB- cord-014516-r59usk02 1634 92 . . . cord-014516-r59usk02 1635 1 Abnormal abnormal JJ cord-014516-r59usk02 1635 2 findings finding NNS cord-014516-r59usk02 1635 3 of of IN cord-014516-r59usk02 1635 4 the the DT cord-014516-r59usk02 1635 5 CBC CBC NNP cord-014516-r59usk02 1635 6 included include VBD cord-014516-r59usk02 1635 7 anemia anemia NN cord-014516-r59usk02 1635 8 ( ( -LRB- cord-014516-r59usk02 1635 9 63 63 CD cord-014516-r59usk02 1635 10 % % NN cord-014516-r59usk02 1635 11 ) ) -RRB- cord-014516-r59usk02 1635 12 , , , cord-014516-r59usk02 1635 13 thrombocytopenia thrombocytopenia NN cord-014516-r59usk02 1635 14 ( ( -LRB- cord-014516-r59usk02 1635 15 62 62 CD cord-014516-r59usk02 1635 16 % % NN cord-014516-r59usk02 1635 17 ) ) -RRB- cord-014516-r59usk02 1635 18 and and CC cord-014516-r59usk02 1635 19 leukocytosis leukocytosis NNP cord-014516-r59usk02 1635 20 ( ( -LRB- cord-014516-r59usk02 1635 21 57 57 CD cord-014516-r59usk02 1635 22 % % NN cord-014516-r59usk02 1635 23 ) ) -RRB- cord-014516-r59usk02 1635 24 . . . cord-014516-r59usk02 1636 1 Biochemistry biochemistry NN cord-014516-r59usk02 1636 2 abnormalities abnormality NNS cord-014516-r59usk02 1636 3 included include VBD cord-014516-r59usk02 1636 4 increased increase VBN cord-014516-r59usk02 1636 5 creatinine creatinine NN cord-014516-r59usk02 1636 6 concentrations concentration NNS cord-014516-r59usk02 1636 7 ( ( -LRB- cord-014516-r59usk02 1636 8 82 82 CD cord-014516-r59usk02 1636 9 % % NN cord-014516-r59usk02 1636 10 ) ) -RRB- cord-014516-r59usk02 1636 11 , , , cord-014516-r59usk02 1636 12 increased increase VBN cord-014516-r59usk02 1636 13 liver liver NN cord-014516-r59usk02 1636 14 enzyme enzyme NN cord-014516-r59usk02 1636 15 activities activity NNS cord-014516-r59usk02 1636 16 ( ( -LRB- cord-014516-r59usk02 1636 17 80 80 CD cord-014516-r59usk02 1636 18 % % NN cord-014516-r59usk02 1636 19 ) ) -RRB- cord-014516-r59usk02 1636 20 , , , cord-014516-r59usk02 1636 21 hyperbilirubinemia hyperbilirubinemia NNP cord-014516-r59usk02 1636 22 ( ( -LRB- cord-014516-r59usk02 1636 23 70 70 CD cord-014516-r59usk02 1636 24 % % NN cord-014516-r59usk02 1636 25 ) ) -RRB- cord-014516-r59usk02 1636 26 , , , cord-014516-r59usk02 1636 27 hyperphosphatemia hyperphosphatemia NNP cord-014516-r59usk02 1636 28 ( ( -LRB- cord-014516-r59usk02 1636 29 67 67 CD cord-014516-r59usk02 1636 30 % % NN cord-014516-r59usk02 1636 31 ) ) -RRB- cord-014516-r59usk02 1636 32 , , , cord-014516-r59usk02 1636 33 hyponatremia hyponatremia NN cord-014516-r59usk02 1636 34 ( ( -LRB- cord-014516-r59usk02 1636 35 63 63 CD cord-014516-r59usk02 1636 36 % % NN cord-014516-r59usk02 1636 37 ) ) -RRB- cord-014516-r59usk02 1636 38 , , , cord-014516-r59usk02 1636 39 and and CC cord-014516-r59usk02 1636 40 hypoalbuminemia hypoalbuminemia NNP cord-014516-r59usk02 1636 41 ( ( -LRB- cord-014516-r59usk02 1636 42 55 55 CD cord-014516-r59usk02 1636 43 % % NN cord-014516-r59usk02 1636 44 ) ) -RRB- cord-014516-r59usk02 1636 45 . . . cord-014516-r59usk02 1637 1 Urinalysis Urinalysis NNP cord-014516-r59usk02 1637 2 often often RB cord-014516-r59usk02 1637 3 revealed reveal VBD cord-014516-r59usk02 1637 4 glucosuria glucosuria NNP cord-014516-r59usk02 1637 5 ( ( -LRB- cord-014516-r59usk02 1637 6 77 77 CD cord-014516-r59usk02 1637 7 % % NN cord-014516-r59usk02 1637 8 ) ) -RRB- cord-014516-r59usk02 1637 9 and and CC cord-014516-r59usk02 1637 10 an an DT cord-014516-r59usk02 1637 11 elevated elevated JJ cord-014516-r59usk02 1637 12 urine urine NN cord-014516-r59usk02 1637 13 - - HYPH cord-014516-r59usk02 1637 14 protein protein NN cord-014516-r59usk02 1637 15 / / SYM cord-014516-r59usk02 1637 16 creatinine creatinine NN cord-014516-r59usk02 1637 17 - - HYPH cord-014516-r59usk02 1637 18 ratio ratio NN cord-014516-r59usk02 1637 19 ( ( -LRB- cord-014516-r59usk02 1637 20 75 75 CD cord-014516-r59usk02 1637 21 % % NN cord-014516-r59usk02 1637 22 ) ) -RRB- cord-014516-r59usk02 1637 23 . . . cord-014516-r59usk02 1638 1 Radiological radiological JJ cord-014516-r59usk02 1638 2 pulmonary pulmonary JJ cord-014516-r59usk02 1638 3 changes change NNS cord-014516-r59usk02 1638 4 were be VBD cord-014516-r59usk02 1638 5 detected detect VBN cord-014516-r59usk02 1638 6 in in IN cord-014516-r59usk02 1638 7 57 57 CD cord-014516-r59usk02 1638 8 % % NN cord-014516-r59usk02 1638 9 of of IN cord-014516-r59usk02 1638 10 the the DT cord-014516-r59usk02 1638 11 dogs dog NNS cord-014516-r59usk02 1638 12 initially initially RB cord-014516-r59usk02 1638 13 or or CC cord-014516-r59usk02 1638 14 during during IN cord-014516-r59usk02 1638 15 the the DT cord-014516-r59usk02 1638 16 course course NN cord-014516-r59usk02 1638 17 of of IN cord-014516-r59usk02 1638 18 disease disease NN cord-014516-r59usk02 1638 19 . . . cord-014516-r59usk02 1639 1 32 32 CD cord-014516-r59usk02 1639 2 dogs dog NNS cord-014516-r59usk02 1639 3 died die VBD cord-014516-r59usk02 1639 4 or or CC cord-014516-r59usk02 1639 5 were be VBD cord-014516-r59usk02 1639 6 euthanized euthanize VBN cord-014516-r59usk02 1639 7 , , , cord-014516-r59usk02 1639 8 24 24 CD cord-014516-r59usk02 1639 9 of of IN cord-014516-r59usk02 1639 10 them -PRON- PRP cord-014516-r59usk02 1639 11 due due JJ cord-014516-r59usk02 1639 12 to to IN cord-014516-r59usk02 1639 13 " " `` cord-014516-r59usk02 1639 14 leptospiral leptospiral JJ cord-014516-r59usk02 1639 15 pulmonary pulmonary JJ cord-014516-r59usk02 1639 16 hemorrhage hemorrhage NN cord-014516-r59usk02 1639 17 syndrome syndrome NN cord-014516-r59usk02 1639 18 " " '' cord-014516-r59usk02 1639 19 . . . cord-014516-r59usk02 1640 1 In in IN cord-014516-r59usk02 1640 2 this this DT cord-014516-r59usk02 1640 3 study study NN cord-014516-r59usk02 1640 4 , , , cord-014516-r59usk02 1640 5 non non JJ cord-014516-r59usk02 1640 6 - - JJ cord-014516-r59usk02 1640 7 vaccine vaccine JJ cord-014516-r59usk02 1640 8 serogroups serogroup NNS cord-014516-r59usk02 1640 9 were be VBD cord-014516-r59usk02 1640 10 the the DT cord-014516-r59usk02 1640 11 most most RBS cord-014516-r59usk02 1640 12 common common JJ cord-014516-r59usk02 1640 13 serogroups serogroup NNS cord-014516-r59usk02 1640 14 detected detect VBN cord-014516-r59usk02 1640 15 by by IN cord-014516-r59usk02 1640 16 MAT MAT NNP cord-014516-r59usk02 1640 17 . . . cord-014516-r59usk02 1641 1 In in IN cord-014516-r59usk02 1641 2 the the DT cord-014516-r59usk02 1641 3 majority majority NN cord-014516-r59usk02 1641 4 of of IN cord-014516-r59usk02 1641 5 patients patient NNS cord-014516-r59usk02 1641 6 renal renal JJ cord-014516-r59usk02 1641 7 ( ( -LRB- cord-014516-r59usk02 1641 8 95 95 CD cord-014516-r59usk02 1641 9 % % NN cord-014516-r59usk02 1641 10 ) ) -RRB- cord-014516-r59usk02 1641 11 and/or and/or CC cord-014516-r59usk02 1641 12 hepatic hepatic JJ cord-014516-r59usk02 1641 13 ( ( -LRB- cord-014516-r59usk02 1641 14 93 93 CD cord-014516-r59usk02 1641 15 % % NN cord-014516-r59usk02 1641 16 ) ) -RRB- cord-014516-r59usk02 1641 17 disease disease NN cord-014516-r59usk02 1641 18 was be VBD cord-014516-r59usk02 1641 19 detected detect VBN cord-014516-r59usk02 1641 20 . . . cord-014516-r59usk02 1642 1 A a DT cord-014516-r59usk02 1642 2 pulmonary pulmonary JJ cord-014516-r59usk02 1642 3 form form NN cord-014516-r59usk02 1642 4 of of IN cord-014516-r59usk02 1642 5 leptospirosis leptospirosis NN cord-014516-r59usk02 1642 6 was be VBD cord-014516-r59usk02 1642 7 present present JJ cord-014516-r59usk02 1642 8 in in IN cord-014516-r59usk02 1642 9 57 57 CD cord-014516-r59usk02 1642 10 % % NN cord-014516-r59usk02 1642 11 of of IN cord-014516-r59usk02 1642 12 the the DT cord-014516-r59usk02 1642 13 dogs dog NNS cord-014516-r59usk02 1642 14 . . . cord-014516-r59usk02 1643 1 Lung lung NN cord-014516-r59usk02 1643 2 involvement involvement NN cord-014516-r59usk02 1643 3 represented represent VBD cord-014516-r59usk02 1643 4 a a DT cord-014516-r59usk02 1643 5 severe severe JJ cord-014516-r59usk02 1643 6 complication complication NN cord-014516-r59usk02 1643 7 causing cause VBG cord-014516-r59usk02 1643 8 increased increase VBN cord-014516-r59usk02 1643 9 mortality mortality NN cord-014516-r59usk02 1643 10 depending depend VBG cord-014516-r59usk02 1643 11 on on IN cord-014516-r59usk02 1643 12 the the DT cord-014516-r59usk02 1643 13 severity severity NN cord-014516-r59usk02 1643 14 of of IN cord-014516-r59usk02 1643 15 respiratory respiratory JJ cord-014516-r59usk02 1643 16 signs sign NNS cord-014516-r59usk02 1643 17 . . . cord-014516-r59usk02 1644 1 No no DT cord-014516-r59usk02 1644 2 conflicts conflict NNS cord-014516-r59usk02 1644 3 of of IN cord-014516-r59usk02 1644 4 interest interest NN cord-014516-r59usk02 1644 5 reported report VBN cord-014516-r59usk02 1644 6 . . . cord-014516-r59usk02 1645 1 Leptospirosis leptospirosis NN cord-014516-r59usk02 1645 2 is be VBZ cord-014516-r59usk02 1645 3 a a DT cord-014516-r59usk02 1645 4 zoonotic zoonotic JJ cord-014516-r59usk02 1645 5 disease disease NN cord-014516-r59usk02 1645 6 that that WDT cord-014516-r59usk02 1645 7 can can MD cord-014516-r59usk02 1645 8 affect affect VB cord-014516-r59usk02 1645 9 multiple multiple JJ cord-014516-r59usk02 1645 10 organs organ NNS cord-014516-r59usk02 1645 11 with with IN cord-014516-r59usk02 1645 12 renal renal JJ cord-014516-r59usk02 1645 13 and and CC cord-014516-r59usk02 1645 14 hepatic hepatic JJ cord-014516-r59usk02 1645 15 involvement involvement NN cord-014516-r59usk02 1645 16 being be VBG cord-014516-r59usk02 1645 17 considered consider VBN cord-014516-r59usk02 1645 18 to to TO cord-014516-r59usk02 1645 19 be be VB cord-014516-r59usk02 1645 20 the the DT cord-014516-r59usk02 1645 21 most most RBS cord-014516-r59usk02 1645 22 common common JJ cord-014516-r59usk02 1645 23 . . . cord-014516-r59usk02 1646 1 The the DT cord-014516-r59usk02 1646 2 aim aim NN cord-014516-r59usk02 1646 3 of of IN cord-014516-r59usk02 1646 4 this this DT cord-014516-r59usk02 1646 5 study study NN cord-014516-r59usk02 1646 6 was be VBD cord-014516-r59usk02 1646 7 to to TO cord-014516-r59usk02 1646 8 evaluate evaluate VB cord-014516-r59usk02 1646 9 a a DT cord-014516-r59usk02 1646 10 large large JJ cord-014516-r59usk02 1646 11 number number NN cord-014516-r59usk02 1646 12 of of IN cord-014516-r59usk02 1646 13 dogs dog NNS cord-014516-r59usk02 1646 14 with with IN cord-014516-r59usk02 1646 15 leptospirosis leptospirosis NN cord-014516-r59usk02 1646 16 for for IN cord-014516-r59usk02 1646 17 cardiac cardiac NN cord-014516-r59usk02 1646 18 and/or and/or CC cord-014516-r59usk02 1646 19 exocrine exocrine JJ cord-014516-r59usk02 1646 20 pancreatic pancreatic JJ cord-014516-r59usk02 1646 21 involvement involvement NN cord-014516-r59usk02 1646 22 . . . cord-014516-r59usk02 1647 1 A a DT cord-014516-r59usk02 1647 2 total total NN cord-014516-r59usk02 1647 3 of of IN cord-014516-r59usk02 1647 4 59 59 CD cord-014516-r59usk02 1647 5 dogs dog NNS cord-014516-r59usk02 1647 6 were be VBD cord-014516-r59usk02 1647 7 diagnosed diagnose VBN cord-014516-r59usk02 1647 8 with with IN cord-014516-r59usk02 1647 9 leptospirosis leptospirosis NN cord-014516-r59usk02 1647 10 based base VBN cord-014516-r59usk02 1647 11 on on IN cord-014516-r59usk02 1647 12 clinical clinical JJ cord-014516-r59usk02 1647 13 signs sign NNS cord-014516-r59usk02 1647 14 and and CC cord-014516-r59usk02 1647 15 either either CC cord-014516-r59usk02 1647 16 microscopic microscopic JJ cord-014516-r59usk02 1647 17 agglutination agglutination NN cord-014516-r59usk02 1647 18 test test NN cord-014516-r59usk02 1647 19 , , , cord-014516-r59usk02 1647 20 blood/ blood/ VBP cord-014516-r59usk02 1647 21 urine urine NN cord-014516-r59usk02 1647 22 polymerase polymerase NN cord-014516-r59usk02 1647 23 chain chain NN cord-014516-r59usk02 1647 24 reaction reaction NN cord-014516-r59usk02 1647 25 , , , cord-014516-r59usk02 1647 26 and/or and/or CC cord-014516-r59usk02 1647 27 histopathology histopathology NN cord-014516-r59usk02 1647 28 . . . cord-014516-r59usk02 1648 1 At at IN cord-014516-r59usk02 1648 2 the the DT cord-014516-r59usk02 1648 3 time time NN cord-014516-r59usk02 1648 4 of of IN cord-014516-r59usk02 1648 5 admission admission NN cord-014516-r59usk02 1648 6 and and CC cord-014516-r59usk02 1648 7 , , , cord-014516-r59usk02 1648 8 in in IN cord-014516-r59usk02 1648 9 most most JJS cord-014516-r59usk02 1648 10 patients patient NNS cord-014516-r59usk02 1648 11 , , , cord-014516-r59usk02 1648 12 after after IN cord-014516-r59usk02 1648 13 an an DT cord-014516-r59usk02 1648 14 average average NN cord-014516-r59usk02 1648 15 of of IN cord-014516-r59usk02 1648 16 two two CD cord-014516-r59usk02 1648 17 weeks week NNS cord-014516-r59usk02 1648 18 canine canine JJ cord-014516-r59usk02 1648 19 pancreatic pancreatic JJ cord-014516-r59usk02 1648 20 lipase lipase NN cord-014516-r59usk02 1648 21 immunoreactivity immunoreactivity NN cord-014516-r59usk02 1648 22 ( ( -LRB- cord-014516-r59usk02 1648 23 cPLI cpli NN cord-014516-r59usk02 1648 24 , , , cord-014516-r59usk02 1648 25 as as IN cord-014516-r59usk02 1648 26 measured measure VBN cord-014516-r59usk02 1648 27 by by IN cord-014516-r59usk02 1648 28 Spec Spec NNP cord-014516-r59usk02 1648 29 cPL cPL NNS cord-014516-r59usk02 1648 30 â â LS cord-014516-r59usk02 1648 31 ) ) -RRB- cord-014516-r59usk02 1648 32 , , , cord-014516-r59usk02 1648 33 ultrasensitive ultrasensitive JJ cord-014516-r59usk02 1648 34 cardiac cardiac NN cord-014516-r59usk02 1648 35 Troponin Troponin NNP cord-014516-r59usk02 1648 36 I -PRON- PRP cord-014516-r59usk02 1648 37 ( ( -LRB- cord-014516-r59usk02 1648 38 cTnI cTnI NNP cord-014516-r59usk02 1648 39 ) ) -RRB- cord-014516-r59usk02 1648 40 , , , cord-014516-r59usk02 1648 41 and and CC cord-014516-r59usk02 1648 42 C C NNP cord-014516-r59usk02 1648 43 - - HYPH cord-014516-r59usk02 1648 44 Reactive Reactive NNP cord-014516-r59usk02 1648 45 Protein Protein NNP cord-014516-r59usk02 1648 46 ( ( -LRB- cord-014516-r59usk02 1648 47 CRP CRP NNP cord-014516-r59usk02 1648 48 ) ) -RRB- cord-014516-r59usk02 1648 49 were be VBD cord-014516-r59usk02 1648 50 analyzed analyze VBN cord-014516-r59usk02 1648 51 . . . cord-014516-r59usk02 1649 1 Data datum NNS cord-014516-r59usk02 1649 2 were be VBD cord-014516-r59usk02 1649 3 analyzed analyze VBN cord-014516-r59usk02 1649 4 with with IN cord-014516-r59usk02 1649 5 non non JJ cord-014516-r59usk02 1649 6 - - JJ cord-014516-r59usk02 1649 7 parametric parametric JJ cord-014516-r59usk02 1649 8 statistics statistic NNS cord-014516-r59usk02 1649 9 . . . cord-014516-r59usk02 1650 1 The the DT cord-014516-r59usk02 1650 2 level level NN cord-014516-r59usk02 1650 3 of of IN cord-014516-r59usk02 1650 4 significance significance NN cord-014516-r59usk02 1650 5 was be VBD cord-014516-r59usk02 1650 6 set set VBN cord-014516-r59usk02 1650 7 at at IN cord-014516-r59usk02 1650 8 p p NN cord-014516-r59usk02 1650 9 < < XX cord-014516-r59usk02 1650 10 0.05 0.05 CD cord-014516-r59usk02 1650 11 . . . cord-014516-r59usk02 1651 1 Upon upon IN cord-014516-r59usk02 1651 2 admission admission NN cord-014516-r59usk02 1651 3 , , , cord-014516-r59usk02 1651 4 common common JJ cord-014516-r59usk02 1651 5 clinical clinical JJ cord-014516-r59usk02 1651 6 signs sign NNS cord-014516-r59usk02 1651 7 reported report VBD cord-014516-r59usk02 1651 8 included include VBN cord-014516-r59usk02 1651 9 lethargy lethargy NN cord-014516-r59usk02 1651 10 ( ( -LRB- cord-014516-r59usk02 1651 11 n n NN cord-014516-r59usk02 1651 12 = = SYM cord-014516-r59usk02 1651 13 57 57 CD cord-014516-r59usk02 1651 14 ) ) -RRB- cord-014516-r59usk02 1651 15 , , , cord-014516-r59usk02 1651 16 vomiting vomit VBG cord-014516-r59usk02 1651 17 ( ( -LRB- cord-014516-r59usk02 1651 18 n n NN cord-014516-r59usk02 1651 19 = = SYM cord-014516-r59usk02 1651 20 50 50 CD cord-014516-r59usk02 1651 21 ) ) -RRB- cord-014516-r59usk02 1651 22 , , , cord-014516-r59usk02 1651 23 abdominal abdominal JJ cord-014516-r59usk02 1651 24 pain pain NN cord-014516-r59usk02 1651 25 ( ( -LRB- cord-014516-r59usk02 1651 26 n n NN cord-014516-r59usk02 1651 27 = = SYM cord-014516-r59usk02 1651 28 20 20 CD cord-014516-r59usk02 1651 29 ) ) -RRB- cord-014516-r59usk02 1651 30 , , , cord-014516-r59usk02 1651 31 dyspnea dyspnea NN cord-014516-r59usk02 1651 32 ( ( -LRB- cord-014516-r59usk02 1651 33 n n NN cord-014516-r59usk02 1651 34 = = SYM cord-014516-r59usk02 1651 35 16 16 CD cord-014516-r59usk02 1651 36 ) ) -RRB- cord-014516-r59usk02 1651 37 , , , cord-014516-r59usk02 1651 38 pale pale JJ cord-014516-r59usk02 1651 39 mucous mucous JJ cord-014516-r59usk02 1651 40 membranes membrane NNS cord-014516-r59usk02 1651 41 ( ( -LRB- cord-014516-r59usk02 1651 42 n n NN cord-014516-r59usk02 1651 43 = = SYM cord-014516-r59usk02 1651 44 13 13 CD cord-014516-r59usk02 1651 45 ) ) -RRB- cord-014516-r59usk02 1651 46 , , . cord-014516-r59usk02 1652 1 oliguria oliguria NNP cord-014516-r59usk02 1652 2 ( ( -LRB- cord-014516-r59usk02 1652 3 n n NN cord-014516-r59usk02 1652 4 = = SYM cord-014516-r59usk02 1652 5 11 11 CD cord-014516-r59usk02 1652 6 ) ) -RRB- cord-014516-r59usk02 1652 7 , , , cord-014516-r59usk02 1652 8 hypothermia hypothermia NN cord-014516-r59usk02 1652 9 ( ( -LRB- cord-014516-r59usk02 1652 10 n n NN cord-014516-r59usk02 1652 11 = = SYM cord-014516-r59usk02 1652 12 11 11 CD cord-014516-r59usk02 1652 13 ) ) -RRB- cord-014516-r59usk02 1652 14 , , , cord-014516-r59usk02 1652 15 and and CC cord-014516-r59usk02 1652 16 fever fever NN cord-014516-r59usk02 1652 17 ( ( -LRB- cord-014516-r59usk02 1652 18 n n NN cord-014516-r59usk02 1652 19 = = SYM cord-014516-r59usk02 1652 20 10 10 CD cord-014516-r59usk02 1652 21 ) ) -RRB- cord-014516-r59usk02 1652 22 . . . cord-014516-r59usk02 1653 1 Anemia anemia NN cord-014516-r59usk02 1653 2 ( ( -LRB- cord-014516-r59usk02 1653 3 n n NN cord-014516-r59usk02 1653 4 = = SYM cord-014516-r59usk02 1653 5 39 39 CD cord-014516-r59usk02 1653 6 ) ) -RRB- cord-014516-r59usk02 1653 7 , , , cord-014516-r59usk02 1653 8 thrombocytopenia thrombocytopenia NN cord-014516-r59usk02 1653 9 ( ( -LRB- cord-014516-r59usk02 1653 10 n n NN cord-014516-r59usk02 1653 11 = = SYM cord-014516-r59usk02 1653 12 41 41 CD cord-014516-r59usk02 1653 13 ) ) -RRB- cord-014516-r59usk02 1653 14 , , , cord-014516-r59usk02 1653 15 leukocytosis leukocytosis NNP cord-014516-r59usk02 1653 16 ( ( -LRB- cord-014516-r59usk02 1653 17 n n NN cord-014516-r59usk02 1653 18 = = SYM cord-014516-r59usk02 1653 19 38 38 CD cord-014516-r59usk02 1653 20 ) ) -RRB- cord-014516-r59usk02 1653 21 , , , cord-014516-r59usk02 1653 22 were be VBD cord-014516-r59usk02 1653 23 frequently frequently RB cord-014516-r59usk02 1653 24 reported report VBN cord-014516-r59usk02 1653 25 hematology hematology NN cord-014516-r59usk02 1653 26 findings finding NNS cord-014516-r59usk02 1653 27 . . . cord-014516-r59usk02 1654 1 Increased increase VBN cord-014516-r59usk02 1654 2 concentrations concentration NNS cord-014516-r59usk02 1654 3 of of IN cord-014516-r59usk02 1654 4 creatinine creatinine NN cord-014516-r59usk02 1654 5 ( ( -LRB- cord-014516-r59usk02 1654 6 n n NN cord-014516-r59usk02 1654 7 = = SYM cord-014516-r59usk02 1654 8 48/59 48/59 CD cord-014516-r59usk02 1654 9 ) ) -RRB- cord-014516-r59usk02 1654 10 , , , cord-014516-r59usk02 1654 11 phosphorus phosphorus NNP cord-014516-r59usk02 1654 12 ( ( -LRB- cord-014516-r59usk02 1654 13 n n NN cord-014516-r59usk02 1654 14 = = SYM cord-014516-r59usk02 1654 15 43/57 43/57 CD cord-014516-r59usk02 1654 16 ) ) -RRB- cord-014516-r59usk02 1654 17 , , , cord-014516-r59usk02 1654 18 ALT ALT NNP cord-014516-r59usk02 1654 19 ( ( -LRB- cord-014516-r59usk02 1654 20 n n NN cord-014516-r59usk02 1654 21 = = SYM cord-014516-r59usk02 1654 22 31/ 31/ CD cord-014516-r59usk02 1654 23 58 58 CD cord-014516-r59usk02 1654 24 ) ) -RRB- cord-014516-r59usk02 1654 25 , , , cord-014516-r59usk02 1654 26 SAP SAP NNP cord-014516-r59usk02 1654 27 ( ( -LRB- cord-014516-r59usk02 1654 28 n n NN cord-014516-r59usk02 1654 29 = = SYM cord-014516-r59usk02 1654 30 43/57 43/57 CD cord-014516-r59usk02 1654 31 ) ) -RRB- cord-014516-r59usk02 1654 32 and and CC cord-014516-r59usk02 1654 33 bilirubin bilirubin NN cord-014516-r59usk02 1654 34 ( ( -LRB- cord-014516-r59usk02 1654 35 n n NN cord-014516-r59usk02 1654 36 = = SYM cord-014516-r59usk02 1654 37 41/58 41/58 CD cord-014516-r59usk02 1654 38 ) ) -RRB- cord-014516-r59usk02 1654 39 were be VBD cord-014516-r59usk02 1654 40 also also RB cord-014516-r59usk02 1654 41 frequently frequently RB cord-014516-r59usk02 1654 42 recorded record VBN cord-014516-r59usk02 1654 43 . . . cord-014516-r59usk02 1655 1 CRP CRP NNP cord-014516-r59usk02 1655 2 ( ( -LRB- cord-014516-r59usk02 1655 3 median median NN cord-014516-r59usk02 1655 4 : : : cord-014516-r59usk02 1655 5 48.7 48.7 CD cord-014516-r59usk02 1655 6 mg mg NNP cord-014516-r59usk02 1655 7 / / SYM cord-014516-r59usk02 1655 8 L L NNP cord-014516-r59usk02 1655 9 ; ; : cord-014516-r59usk02 1655 10 range range NN cord-014516-r59usk02 1655 11 : : : cord-014516-r59usk02 1655 12 0.1 0.1 CD cord-014516-r59usk02 1655 13 - - HYPH cord-014516-r59usk02 1655 14 60.1 60.1 CD cord-014516-r59usk02 1655 15 mg mg NNP cord-014516-r59usk02 1655 16 / / SYM cord-014516-r59usk02 1655 17 L L NNP cord-014516-r59usk02 1655 18 , , , cord-014516-r59usk02 1655 19 reference reference NN cord-014516-r59usk02 1655 20 interval interval NN cord-014516-r59usk02 1655 21 ( ( -LRB- cord-014516-r59usk02 1655 22 RI RI NNP cord-014516-r59usk02 1655 23 ) ) -RRB- cord-014516-r59usk02 1655 24 : : : cord-014516-r59usk02 1655 25 0.1 0.1 CD cord-014516-r59usk02 1655 26 - - HYPH cord-014516-r59usk02 1655 27 7.6 7.6 CD cord-014516-r59usk02 1655 28 mg mg NNP cord-014516-r59usk02 1655 29 / / SYM cord-014516-r59usk02 1655 30 L L NNP cord-014516-r59usk02 1655 31 ) ) -RRB- cord-014516-r59usk02 1655 32 , , , cord-014516-r59usk02 1655 33 cTnI cTnI NNP cord-014516-r59usk02 1655 34 ( ( -LRB- cord-014516-r59usk02 1655 35 median median NN cord-014516-r59usk02 1655 36 : : : cord-014516-r59usk02 1655 37 0.137 0.137 CD cord-014516-r59usk02 1655 38 ng ng NNP cord-014516-r59usk02 1655 39 / / SYM cord-014516-r59usk02 1655 40 L l NN cord-014516-r59usk02 1655 41 ; ; : cord-014516-r59usk02 1655 42 range range NN cord-014516-r59usk02 1655 43 : : : cord-014516-r59usk02 1655 44 0.005 0.005 CD cord-014516-r59usk02 1655 45 - - HYPH cord-014516-r59usk02 1655 46 24.063 24.063 CD cord-014516-r59usk02 1655 47 ng ng NNP cord-014516-r59usk02 1655 48 / / SYM cord-014516-r59usk02 1655 49 L L NNP cord-014516-r59usk02 1655 50 , , , cord-014516-r59usk02 1655 51 RI RI NNP cord-014516-r59usk02 1655 52 : : : cord-014516-r59usk02 1655 53 0 0 CD cord-014516-r59usk02 1655 54 - - SYM cord-014516-r59usk02 1655 55 0.059 0.059 CD cord-014516-r59usk02 1655 56 ng ng NNP cord-014516-r59usk02 1655 57 / / SYM cord-014516-r59usk02 1655 58 L L NNP cord-014516-r59usk02 1655 59 ) ) -RRB- cord-014516-r59usk02 1655 60 , , , cord-014516-r59usk02 1655 61 and and CC cord-014516-r59usk02 1655 62 cPLI cpli NN cord-014516-r59usk02 1655 63 ( ( -LRB- cord-014516-r59usk02 1655 64 median median NN cord-014516-r59usk02 1655 65 : : : cord-014516-r59usk02 1655 66 217 217 CD cord-014516-r59usk02 1655 67 lg lg NNP cord-014516-r59usk02 1655 68 / / SYM cord-014516-r59usk02 1655 69 L l NN cord-014516-r59usk02 1655 70 ; ; : cord-014516-r59usk02 1656 1 range range NN cord-014516-r59usk02 1656 2 : : : cord-014516-r59usk02 1656 3 29 29 CD cord-014516-r59usk02 1656 4 - - SYM cord-014516-r59usk02 1656 5 1001 1001 CD cord-014516-r59usk02 1656 6 lg lg NNP cord-014516-r59usk02 1656 7 / / SYM cord-014516-r59usk02 1656 8 L L NNP cord-014516-r59usk02 1656 9 , , , cord-014516-r59usk02 1656 10 RI RI NNP cord-014516-r59usk02 1656 11 : : : cord-014516-r59usk02 1656 12 0 0 CD cord-014516-r59usk02 1656 13 - - SYM cord-014516-r59usk02 1656 14 200 200 CD cord-014516-r59usk02 1656 15 lg lg NNP cord-014516-r59usk02 1656 16 / / SYM cord-014516-r59usk02 1656 17 L L NNP cord-014516-r59usk02 1656 18 ) ) -RRB- cord-014516-r59usk02 1656 19 concentrations concentration NNS cord-014516-r59usk02 1656 20 were be VBD cord-014516-r59usk02 1656 21 above above IN cord-014516-r59usk02 1656 22 the the DT cord-014516-r59usk02 1656 23 upper upper JJ cord-014516-r59usk02 1656 24 limit limit NN cord-014516-r59usk02 1656 25 of of IN cord-014516-r59usk02 1656 26 the the DT cord-014516-r59usk02 1656 27 reference reference NN cord-014516-r59usk02 1656 28 intervals interval NNS cord-014516-r59usk02 1656 29 in in IN cord-014516-r59usk02 1656 30 52/59 52/59 CD cord-014516-r59usk02 1656 31 ( ( -LRB- cord-014516-r59usk02 1656 32 88 88 CD cord-014516-r59usk02 1656 33 % % NN cord-014516-r59usk02 1656 34 ) ) -RRB- cord-014516-r59usk02 1656 35 , , , cord-014516-r59usk02 1656 36 42/59 42/59 CD cord-014516-r59usk02 1656 37 ( ( -LRB- cord-014516-r59usk02 1656 38 71 71 CD cord-014516-r59usk02 1656 39 % % NN cord-014516-r59usk02 1656 40 ) ) -RRB- cord-014516-r59usk02 1656 41 , , , cord-014516-r59usk02 1656 42 and and CC cord-014516-r59usk02 1656 43 30/59 30/59 CD cord-014516-r59usk02 1656 44 ( ( -LRB- cord-014516-r59usk02 1656 45 51 51 CD cord-014516-r59usk02 1656 46 % % NN cord-014516-r59usk02 1656 47 ) ) -RRB- cord-014516-r59usk02 1657 1 dogs dog NNS cord-014516-r59usk02 1657 2 , , , cord-014516-r59usk02 1657 3 respectively respectively RB cord-014516-r59usk02 1657 4 and and CC cord-014516-r59usk02 1657 5 serum serum NN cord-014516-r59usk02 1657 6 cPLI cpli NN cord-014516-r59usk02 1657 7 concentration concentration NN cord-014516-r59usk02 1657 8 was be VBD cord-014516-r59usk02 1657 9 above above IN cord-014516-r59usk02 1657 10 the the DT cord-014516-r59usk02 1657 11 suggested suggested JJ cord-014516-r59usk02 1657 12 cut cut VBN cord-014516-r59usk02 1657 13 - - HYPH cord-014516-r59usk02 1657 14 off off RP cord-014516-r59usk02 1657 15 value value NN cord-014516-r59usk02 1657 16 for for IN cord-014516-r59usk02 1657 17 a a DT cord-014516-r59usk02 1657 18 diagnosis diagnosis NN cord-014516-r59usk02 1657 19 of of IN cord-014516-r59usk02 1657 20 pancreatitis pancreatitis NN cord-014516-r59usk02 1657 21 in in IN cord-014516-r59usk02 1657 22 15/59 15/59 CD cord-014516-r59usk02 1657 23 ( ( -LRB- cord-014516-r59usk02 1657 24 25 25 CD cord-014516-r59usk02 1657 25 % % NN cord-014516-r59usk02 1657 26 ) ) -RRB- cord-014516-r59usk02 1657 27 dogs dog NNS cord-014516-r59usk02 1657 28 . . . cord-014516-r59usk02 1658 1 CRP CRP NNP cord-014516-r59usk02 1658 2 and and CC cord-014516-r59usk02 1658 3 cTnI cTnI NNP cord-014516-r59usk02 1658 4 , , , cord-014516-r59usk02 1658 5 but but CC cord-014516-r59usk02 1658 6 not not RB cord-014516-r59usk02 1658 7 cPLI cPLI NNS cord-014516-r59usk02 1658 8 were be VBD cord-014516-r59usk02 1658 9 higher high JJR cord-014516-r59usk02 1658 10 upon upon IN cord-014516-r59usk02 1658 11 admission admission NN cord-014516-r59usk02 1658 12 compared compare VBN cord-014516-r59usk02 1658 13 to to IN cord-014516-r59usk02 1658 14 the the DT cord-014516-r59usk02 1658 15 re re NN cord-014516-r59usk02 1658 16 - - NN cord-014516-r59usk02 1658 17 check check VB cord-014516-r59usk02 1658 18 measurement measurement NN cord-014516-r59usk02 1658 19 ( ( -LRB- cord-014516-r59usk02 1658 20 p p NN cord-014516-r59usk02 1658 21 = = SYM cord-014516-r59usk02 1658 22 0.0001 0.0001 CD cord-014516-r59usk02 1658 23 and and CC cord-014516-r59usk02 1658 24 0.0056 0.0056 CD cord-014516-r59usk02 1658 25 , , , cord-014516-r59usk02 1658 26 respectively respectively RB cord-014516-r59usk02 1658 27 ) ) -RRB- cord-014516-r59usk02 1658 28 . . . cord-014516-r59usk02 1659 1 Dogs dog NNS cord-014516-r59usk02 1659 2 with with IN cord-014516-r59usk02 1659 3 increased increased JJ cord-014516-r59usk02 1659 4 serum serum NN cord-014516-r59usk02 1659 5 cPLI cpli NN cord-014516-r59usk02 1659 6 concentrations concentration NNS cord-014516-r59usk02 1659 7 also also RB cord-014516-r59usk02 1659 8 showed show VBD cord-014516-r59usk02 1659 9 a a DT cord-014516-r59usk02 1659 10 higher high JJR cord-014516-r59usk02 1659 11 proportion proportion NN cord-014516-r59usk02 1659 12 of of IN cord-014516-r59usk02 1659 13 dogs dog NNS cord-014516-r59usk02 1659 14 with with IN cord-014516-r59usk02 1659 15 increased increase VBN cord-014516-r59usk02 1659 16 serum serum NN cord-014516-r59usk02 1659 17 cTnI cTnI NNP cord-014516-r59usk02 1659 18 concentrations concentration NNS cord-014516-r59usk02 1659 19 ( ( -LRB- cord-014516-r59usk02 1659 20 p p NN cord-014516-r59usk02 1659 21 = = SYM cord-014516-r59usk02 1659 22 0.001 0.001 CD cord-014516-r59usk02 1659 23 ) ) -RRB- cord-014516-r59usk02 1659 24 . . . cord-014516-r59usk02 1660 1 There there EX cord-014516-r59usk02 1660 2 was be VBD cord-014516-r59usk02 1660 3 no no DT cord-014516-r59usk02 1660 4 statistically statistically RB cord-014516-r59usk02 1660 5 significant significant JJ cord-014516-r59usk02 1660 6 correlation correlation NN cord-014516-r59usk02 1660 7 of of IN cord-014516-r59usk02 1660 8 cPLI cpli NN cord-014516-r59usk02 1660 9 concentrations concentration NNS cord-014516-r59usk02 1660 10 with with IN cord-014516-r59usk02 1660 11 a a DT cord-014516-r59usk02 1660 12 history history NN cord-014516-r59usk02 1660 13 of of IN cord-014516-r59usk02 1660 14 abdominal abdominal JJ cord-014516-r59usk02 1660 15 pain pain NN cord-014516-r59usk02 1660 16 and/or and/or CC cord-014516-r59usk02 1660 17 vomiting vomiting NN cord-014516-r59usk02 1660 18 . . . cord-014516-r59usk02 1661 1 Biochemical biochemical JJ cord-014516-r59usk02 1661 2 results result NNS cord-014516-r59usk02 1661 3 were be VBD cord-014516-r59usk02 1661 4 compatible compatible JJ cord-014516-r59usk02 1661 5 with with IN cord-014516-r59usk02 1661 6 multiple multiple JJ cord-014516-r59usk02 1661 7 organ organ NN cord-014516-r59usk02 1661 8 impairment impairment NN cord-014516-r59usk02 1661 9 with with IN cord-014516-r59usk02 1661 10 involvement involvement NN cord-014516-r59usk02 1661 11 of of IN cord-014516-r59usk02 1661 12 kidneys kidney NNS cord-014516-r59usk02 1661 13 , , , cord-014516-r59usk02 1661 14 liver liver NN cord-014516-r59usk02 1661 15 , , , cord-014516-r59usk02 1661 16 heart heart NN cord-014516-r59usk02 1661 17 , , , cord-014516-r59usk02 1661 18 and and CC cord-014516-r59usk02 1661 19 exocrine exocrine JJ cord-014516-r59usk02 1661 20 pancreas pancrea NNS cord-014516-r59usk02 1661 21 where where WRB cord-014516-r59usk02 1661 22 at at RB cord-014516-r59usk02 1661 23 least least RBS cord-014516-r59usk02 1661 24 two two CD cord-014516-r59usk02 1661 25 organs organ NNS cord-014516-r59usk02 1661 26 were be VBD cord-014516-r59usk02 1661 27 affected affect VBN cord-014516-r59usk02 1661 28 in in IN cord-014516-r59usk02 1661 29 36/59 36/59 CD cord-014516-r59usk02 1661 30 ( ( -LRB- cord-014516-r59usk02 1661 31 61 61 CD cord-014516-r59usk02 1661 32 % % NN cord-014516-r59usk02 1661 33 ) ) -RRB- cord-014516-r59usk02 1661 34 dogs dog NNS cord-014516-r59usk02 1661 35 . . . cord-014516-r59usk02 1662 1 Forty forty CD cord-014516-r59usk02 1662 2 ( ( -LRB- cord-014516-r59usk02 1662 3 68 68 CD cord-014516-r59usk02 1662 4 % % NN cord-014516-r59usk02 1662 5 ) ) -RRB- cord-014516-r59usk02 1662 6 of of IN cord-014516-r59usk02 1662 7 59 59 CD cord-014516-r59usk02 1662 8 dogs dog NNS cord-014516-r59usk02 1662 9 recovered recover VBN cord-014516-r59usk02 1662 10 , , , cord-014516-r59usk02 1662 11 10 10 CD cord-014516-r59usk02 1662 12 ( ( -LRB- cord-014516-r59usk02 1662 13 17 17 CD cord-014516-r59usk02 1662 14 % % NN cord-014516-r59usk02 1662 15 ) ) -RRB- cord-014516-r59usk02 1662 16 died die VBD cord-014516-r59usk02 1662 17 , , , cord-014516-r59usk02 1662 18 and and CC cord-014516-r59usk02 1662 19 9 9 CD cord-014516-r59usk02 1662 20 ( ( -LRB- cord-014516-r59usk02 1662 21 15 15 CD cord-014516-r59usk02 1662 22 % % NN cord-014516-r59usk02 1662 23 ) ) -RRB- cord-014516-r59usk02 1662 24 were be VBD cord-014516-r59usk02 1662 25 euthanized euthanize VBN cord-014516-r59usk02 1662 26 . . . cord-014516-r59usk02 1663 1 cTnI cTnI NNP cord-014516-r59usk02 1663 2 and and CC cord-014516-r59usk02 1663 3 cPLI cPLI NNS cord-014516-r59usk02 1663 4 were be VBD cord-014516-r59usk02 1663 5 higher high JJR cord-014516-r59usk02 1663 6 in in IN cord-014516-r59usk02 1663 7 non non NNS cord-014516-r59usk02 1663 8 - - NNS cord-014516-r59usk02 1663 9 survivors survivor NNS cord-014516-r59usk02 1663 10 , , , cord-014516-r59usk02 1663 11 but but CC cord-014516-r59usk02 1663 12 these these DT cord-014516-r59usk02 1663 13 differences difference NNS cord-014516-r59usk02 1663 14 did do VBD cord-014516-r59usk02 1663 15 not not RB cord-014516-r59usk02 1663 16 reach reach VB cord-014516-r59usk02 1663 17 statistical statistical JJ cord-014516-r59usk02 1663 18 significance significance NN cord-014516-r59usk02 1663 19 . . . cord-014516-r59usk02 1664 1 However however RB cord-014516-r59usk02 1664 2 , , , cord-014516-r59usk02 1664 3 the the DT cord-014516-r59usk02 1664 4 number number NN cord-014516-r59usk02 1664 5 of of IN cord-014516-r59usk02 1664 6 organs organ NNS cord-014516-r59usk02 1664 7 affected affect VBN cord-014516-r59usk02 1664 8 and and CC cord-014516-r59usk02 1664 9 outcome outcome NN cord-014516-r59usk02 1664 10 were be VBD cord-014516-r59usk02 1664 11 significantly significantly RB cord-014516-r59usk02 1664 12 correlated correlate VBN cord-014516-r59usk02 1664 13 ( ( -LRB- cord-014516-r59usk02 1664 14 p p NN cord-014516-r59usk02 1664 15 = = SYM cord-014516-r59usk02 1664 16 0.012 0.012 CD cord-014516-r59usk02 1664 17 ) ) -RRB- cord-014516-r59usk02 1664 18 . . . cord-014516-r59usk02 1665 1 Our -PRON- PRP$ cord-014516-r59usk02 1665 2 data datum NNS cord-014516-r59usk02 1665 3 suggest suggest VBP cord-014516-r59usk02 1665 4 that that IN cord-014516-r59usk02 1665 5 infection infection NN cord-014516-r59usk02 1665 6 with with IN cord-014516-r59usk02 1665 7 Leptospira Leptospira NNP cord-014516-r59usk02 1665 8 is be VBZ cord-014516-r59usk02 1665 9 characterized characterize VBN cord-014516-r59usk02 1665 10 by by IN cord-014516-r59usk02 1665 11 a a DT cord-014516-r59usk02 1665 12 systemic systemic JJ cord-014516-r59usk02 1665 13 inflammation inflammation NN cord-014516-r59usk02 1665 14 with with IN cord-014516-r59usk02 1665 15 variable variable JJ cord-014516-r59usk02 1665 16 multiple multiple JJ cord-014516-r59usk02 1665 17 organ organ NN cord-014516-r59usk02 1665 18 involvement involvement NN cord-014516-r59usk02 1665 19 and and CC cord-014516-r59usk02 1665 20 damage damage NN cord-014516-r59usk02 1665 21 , , , cord-014516-r59usk02 1665 22 often often RB cord-014516-r59usk02 1665 23 including include VBG cord-014516-r59usk02 1665 24 the the DT cord-014516-r59usk02 1665 25 heart heart NN cord-014516-r59usk02 1665 26 and and CC cord-014516-r59usk02 1665 27 also also RB cord-014516-r59usk02 1665 28 the the DT cord-014516-r59usk02 1665 29 exocrine exocrine JJ cord-014516-r59usk02 1665 30 pancreas pancrea NNS cord-014516-r59usk02 1665 31 . . . cord-014516-r59usk02 1666 1 The the DT cord-014516-r59usk02 1666 2 study study NN cord-014516-r59usk02 1666 3 was be VBD cord-014516-r59usk02 1666 4 funded fund VBN cord-014516-r59usk02 1666 5 by by IN cord-014516-r59usk02 1666 6 Texas Texas NNP cord-014516-r59usk02 1666 7 A&M A&M NNP cord-014516-r59usk02 1666 8 University University NNP cord-014516-r59usk02 1666 9 . . . cord-014516-r59usk02 1667 1 The the DT cord-014516-r59usk02 1667 2 primary primary JJ cord-014516-r59usk02 1667 3 author author NN cord-014516-r59usk02 1667 4 and and CC cord-014516-r59usk02 1667 5 two two CD cord-014516-r59usk02 1667 6 co co NNS cord-014516-r59usk02 1667 7 - - NNS cord-014516-r59usk02 1667 8 authors author NNS cord-014516-r59usk02 1667 9 work work VBP cord-014516-r59usk02 1667 10 at at IN cord-014516-r59usk02 1667 11 the the DT cord-014516-r59usk02 1667 12 GI GI NNP cord-014516-r59usk02 1667 13 Laboratory Laboratory NNP cord-014516-r59usk02 1667 14 , , , cord-014516-r59usk02 1667 15 Texa Texa NNP cord-014516-r59usk02 1667 16 A&M A&M NNP cord-014516-r59usk02 1667 17 University University NNP cord-014516-r59usk02 1667 18 . . . cord-014516-r59usk02 1668 1 Canine canine JJ cord-014516-r59usk02 1668 2 bartonellosis bartonellosis NN cord-014516-r59usk02 1668 3 is be VBZ cord-014516-r59usk02 1668 4 increasingly increasingly RB cord-014516-r59usk02 1668 5 recognized recognize VBN cord-014516-r59usk02 1668 6 worldwide worldwide RB cord-014516-r59usk02 1668 7 and and CC cord-014516-r59usk02 1668 8 may may MD cord-014516-r59usk02 1668 9 be be VB cord-014516-r59usk02 1668 10 associated associate VBN cord-014516-r59usk02 1668 11 with with IN cord-014516-r59usk02 1668 12 diverse diverse JJ cord-014516-r59usk02 1668 13 clinical clinical JJ cord-014516-r59usk02 1668 14 manifestations manifestation NNS cord-014516-r59usk02 1668 15 . . . cord-014516-r59usk02 1669 1 Recent recent JJ cord-014516-r59usk02 1669 2 evidence evidence NN cord-014516-r59usk02 1669 3 suggests suggest VBZ cord-014516-r59usk02 1669 4 that that IN cord-014516-r59usk02 1669 5 bartonellosis bartonellosis NNP cord-014516-r59usk02 1669 6 also also RB cord-014516-r59usk02 1669 7 causes cause VBZ cord-014516-r59usk02 1669 8 lameness lameness NN cord-014516-r59usk02 1669 9 and and CC cord-014516-r59usk02 1669 10 polyarthritis polyarthritis NN cord-014516-r59usk02 1669 11 in in IN cord-014516-r59usk02 1669 12 dogs dog NNS cord-014516-r59usk02 1669 13 . . . cord-014516-r59usk02 1670 1 However however RB cord-014516-r59usk02 1670 2 , , , cord-014516-r59usk02 1670 3 PCR PCR NNP cord-014516-r59usk02 1670 4 amplification amplification NN cord-014516-r59usk02 1670 5 of of IN cord-014516-r59usk02 1670 6 Bartonella Bartonella NNP cord-014516-r59usk02 1670 7 DNA DNA NNP cord-014516-r59usk02 1670 8 and and CC cord-014516-r59usk02 1670 9 isolation isolation NN cord-014516-r59usk02 1670 10 of of IN cord-014516-r59usk02 1670 11 Bartonella Bartonella NNP cord-014516-r59usk02 1670 12 species specie NNS cord-014516-r59usk02 1670 13 from from IN cord-014516-r59usk02 1670 14 canine canine JJ cord-014516-r59usk02 1670 15 synovial synovial JJ cord-014516-r59usk02 1670 16 fluid fluid NN cord-014516-r59usk02 1670 17 ( ( -LRB- cord-014516-r59usk02 1670 18 SF SF NNP cord-014516-r59usk02 1670 19 ) ) -RRB- cord-014516-r59usk02 1670 20 samples sample NNS cord-014516-r59usk02 1670 21 have have VBP cord-014516-r59usk02 1670 22 rarely rarely RB cord-014516-r59usk02 1670 23 been be VBN cord-014516-r59usk02 1670 24 reported report VBN cord-014516-r59usk02 1670 25 . . . cord-014516-r59usk02 1671 1 Canine canine JJ cord-014516-r59usk02 1671 2 leishmaniosis leishmaniosis NN cord-014516-r59usk02 1671 3 ( ( -LRB- cord-014516-r59usk02 1671 4 CanL CanL NNP cord-014516-r59usk02 1671 5 ) ) -RRB- cord-014516-r59usk02 1671 6 due due IN cord-014516-r59usk02 1671 7 to to IN cord-014516-r59usk02 1671 8 Leishmania Leishmania NNP cord-014516-r59usk02 1671 9 infantum infantum NN cord-014516-r59usk02 1671 10 is be VBZ cord-014516-r59usk02 1671 11 a a DT cord-014516-r59usk02 1671 12 multisystemic multisystemic JJ cord-014516-r59usk02 1671 13 disease disease NN cord-014516-r59usk02 1671 14 commonly commonly RB cord-014516-r59usk02 1671 15 associated associate VBN cord-014516-r59usk02 1671 16 with with IN cord-014516-r59usk02 1671 17 polyarthritis polyarthritis NNP cord-014516-r59usk02 1671 18 . . . cord-014516-r59usk02 1672 1 Based base VBN cord-014516-r59usk02 1672 2 on on IN cord-014516-r59usk02 1672 3 the the DT cord-014516-r59usk02 1672 4 hypothesis hypothesis NN cord-014516-r59usk02 1672 5 that that IN cord-014516-r59usk02 1672 6 concurrent concurrent JJ cord-014516-r59usk02 1672 7 Bartonella Bartonella NNP cord-014516-r59usk02 1672 8 infection infection NN cord-014516-r59usk02 1672 9 may may MD cord-014516-r59usk02 1672 10 be be VB cord-014516-r59usk02 1672 11 a a DT cord-014516-r59usk02 1672 12 contributing contribute VBG cord-014516-r59usk02 1672 13 factor factor NN cord-014516-r59usk02 1672 14 for for IN cord-014516-r59usk02 1672 15 the the DT cord-014516-r59usk02 1672 16 development development NN cord-014516-r59usk02 1672 17 of of IN cord-014516-r59usk02 1672 18 arthritis arthritis NN cord-014516-r59usk02 1672 19 in in IN cord-014516-r59usk02 1672 20 dogs dog NNS cord-014516-r59usk02 1672 21 with with IN cord-014516-r59usk02 1672 22 CanL CanL NNP cord-014516-r59usk02 1672 23 , , , cord-014516-r59usk02 1672 24 the the DT cord-014516-r59usk02 1672 25 main main JJ cord-014516-r59usk02 1672 26 objective objective NN cord-014516-r59usk02 1672 27 of of IN cord-014516-r59usk02 1672 28 this this DT cord-014516-r59usk02 1672 29 study study NN cord-014516-r59usk02 1672 30 was be VBD cord-014516-r59usk02 1672 31 to to TO cord-014516-r59usk02 1672 32 investigate investigate VB cord-014516-r59usk02 1672 33 the the DT cord-014516-r59usk02 1672 34 microbiological microbiological JJ cord-014516-r59usk02 1672 35 and and CC cord-014516-r59usk02 1672 36 molecular molecular JJ cord-014516-r59usk02 1672 37 prevalence prevalence NN cord-014516-r59usk02 1672 38 of of IN cord-014516-r59usk02 1672 39 Bartonella Bartonella NNP cord-014516-r59usk02 1672 40 spp spp NNS cord-014516-r59usk02 1672 41 . . . cord-014516-r59usk02 1673 1 in in IN cord-014516-r59usk02 1673 2 dogs dog NNS cord-014516-r59usk02 1673 3 with with IN cord-014516-r59usk02 1673 4 naturally naturally RB cord-014516-r59usk02 1673 5 - - HYPH cord-014516-r59usk02 1673 6 occurring occur VBG cord-014516-r59usk02 1673 7 CanL CanL NNP cord-014516-r59usk02 1673 8 , , , cord-014516-r59usk02 1673 9 with with IN cord-014516-r59usk02 1673 10 or or CC cord-014516-r59usk02 1673 11 without without IN cord-014516-r59usk02 1673 12 cytologically cytologically RB cord-014516-r59usk02 1673 13 documented document VBN cord-014516-r59usk02 1673 14 arthritis arthritis NN cord-014516-r59usk02 1673 15 . . . cord-014516-r59usk02 1674 1 From from IN cord-014516-r59usk02 1674 2 a a DT cord-014516-r59usk02 1674 3 previous previous JJ cord-014516-r59usk02 1674 4 study study NN cord-014516-r59usk02 1674 5 , , , cord-014516-r59usk02 1674 6 38 38 CD cord-014516-r59usk02 1674 7 dogs dog NNS cord-014516-r59usk02 1674 8 with with IN cord-014516-r59usk02 1674 9 CanL CanL NNP cord-014516-r59usk02 1674 10 were be VBD cord-014516-r59usk02 1674 11 retrospectively retrospectively RB cord-014516-r59usk02 1674 12 studied study VBN cord-014516-r59usk02 1674 13 for for IN cord-014516-r59usk02 1674 14 Bartonella Bartonella NNP cord-014516-r59usk02 1674 15 spp spp NNS cord-014516-r59usk02 1674 16 . . . cord-014516-r59usk02 1675 1 infection infection NN cord-014516-r59usk02 1675 2 . . . cord-014516-r59usk02 1676 1 Diagnosis diagnosis NN cord-014516-r59usk02 1676 2 of of IN cord-014516-r59usk02 1676 3 CanL CanL NNP cord-014516-r59usk02 1676 4 was be VBD cord-014516-r59usk02 1676 5 based base VBN cord-014516-r59usk02 1676 6 on on IN cord-014516-r59usk02 1676 7 compatible compatible JJ cord-014516-r59usk02 1676 8 clinical clinical JJ cord-014516-r59usk02 1676 9 and and CC cord-014516-r59usk02 1676 10 clinicopathological clinicopathological JJ cord-014516-r59usk02 1676 11 abnormalities abnormality NNS cord-014516-r59usk02 1676 12 , , , cord-014516-r59usk02 1676 13 positive positive JJ cord-014516-r59usk02 1676 14 serology serology NN cord-014516-r59usk02 1676 15 , , , cord-014516-r59usk02 1676 16 and and CC cord-014516-r59usk02 1676 17 lymph lymph NN cord-014516-r59usk02 1676 18 node node NN cord-014516-r59usk02 1676 19 or or CC cord-014516-r59usk02 1676 20 bone bone NN cord-014516-r59usk02 1676 21 marrow marrow NN cord-014516-r59usk02 1676 22 ( ( -LRB- cord-014516-r59usk02 1676 23 BM BM NNP cord-014516-r59usk02 1676 24 ) ) -RRB- cord-014516-r59usk02 1676 25 cytology cytology NN cord-014516-r59usk02 1676 26 . . . cord-014516-r59usk02 1677 1 Dogs dog NNS cord-014516-r59usk02 1677 2 with with IN cord-014516-r59usk02 1677 3 serological serological JJ cord-014516-r59usk02 1677 4 evidence evidence NN cord-014516-r59usk02 1677 5 of of IN cord-014516-r59usk02 1677 6 other other JJ cord-014516-r59usk02 1677 7 vector vector NN cord-014516-r59usk02 1677 8 - - HYPH cord-014516-r59usk02 1677 9 borne bear VBN cord-014516-r59usk02 1677 10 infections infection NNS cord-014516-r59usk02 1677 11 ( ( -LRB- cord-014516-r59usk02 1677 12 anaplasmosis anaplasmosis NNP cord-014516-r59usk02 1677 13 , , , cord-014516-r59usk02 1677 14 borelliosis borelliosis NNP cord-014516-r59usk02 1677 15 , , , cord-014516-r59usk02 1677 16 dirofilariosis dirofilariosis NNP cord-014516-r59usk02 1677 17 and and CC cord-014516-r59usk02 1677 18 ehrlichiosis ehrlichiosis NNP cord-014516-r59usk02 1677 19 ) ) -RRB- cord-014516-r59usk02 1677 20 and and CC cord-014516-r59usk02 1677 21 dogs dog NNS cord-014516-r59usk02 1677 22 recently recently RB cord-014516-r59usk02 1677 23 vaccinated vaccinate VBD cord-014516-r59usk02 1677 24 or or CC cord-014516-r59usk02 1677 25 medicated medicate VBN cord-014516-r59usk02 1677 26 were be VBD cord-014516-r59usk02 1677 27 excluded exclude VBN cord-014516-r59usk02 1677 28 from from IN cord-014516-r59usk02 1677 29 the the DT cord-014516-r59usk02 1677 30 study study NN cord-014516-r59usk02 1677 31 . . . cord-014516-r59usk02 1678 1 Arthritis arthritis NN cord-014516-r59usk02 1678 2 defined define VBN cord-014516-r59usk02 1678 3 as as IN cord-014516-r59usk02 1678 4 a a DT cord-014516-r59usk02 1678 5 neutrophil neutrophil NN cord-014516-r59usk02 1678 6 percentage percentage NN cord-014516-r59usk02 1678 7 in in IN cord-014516-r59usk02 1678 8 excess excess NN cord-014516-r59usk02 1678 9 of of IN cord-014516-r59usk02 1678 10 10 10 CD cord-014516-r59usk02 1678 11 % % NN cord-014516-r59usk02 1678 12 of of IN cord-014516-r59usk02 1678 13 nucleated nucleated JJ cord-014516-r59usk02 1678 14 cells cell NNS cord-014516-r59usk02 1678 15 in in IN cord-014516-r59usk02 1678 16 SF SF NNP cord-014516-r59usk02 1678 17 cytology cytology NN cord-014516-r59usk02 1678 18 was be VBD cord-014516-r59usk02 1678 19 documented document VBN cord-014516-r59usk02 1678 20 in in IN cord-014516-r59usk02 1678 21 31/ 31/ CD cord-014516-r59usk02 1678 22 38 38 CD cord-014516-r59usk02 1678 23 ( ( -LRB- cord-014516-r59usk02 1678 24 81.6 81.6 CD cord-014516-r59usk02 1678 25 % % NN cord-014516-r59usk02 1678 26 ) ) -RRB- cord-014516-r59usk02 1678 27 of of IN cord-014516-r59usk02 1678 28 dogs dog NNS cord-014516-r59usk02 1678 29 . . . cord-014516-r59usk02 1679 1 A a DT cord-014516-r59usk02 1679 2 total total NN cord-014516-r59usk02 1679 3 of of IN cord-014516-r59usk02 1679 4 74 74 CD cord-014516-r59usk02 1679 5 archived archived JJ cord-014516-r59usk02 1679 6 specimens specimen NNS cord-014516-r59usk02 1679 7 from from IN cord-014516-r59usk02 1679 8 38 38 CD cord-014516-r59usk02 1679 9 dogs dog NNS cord-014516-r59usk02 1679 10 , , , cord-014516-r59usk02 1679 11 including include VBG cord-014516-r59usk02 1679 12 33 33 CD cord-014516-r59usk02 1679 13 EDTA EDTA NNP cord-014516-r59usk02 1679 14 - - HYPH cord-014516-r59usk02 1679 15 anticoagulated anticoagulate VBN cord-014516-r59usk02 1679 16 blood blood NN cord-014516-r59usk02 1679 17 samples sample NNS cord-014516-r59usk02 1679 18 , , , cord-014516-r59usk02 1679 19 19 19 CD cord-014516-r59usk02 1679 20 BM BM NNP cord-014516-r59usk02 1679 21 and and CC cord-014516-r59usk02 1679 22 22 22 CD cord-014516-r59usk02 1679 23 SF SF NNP cord-014516-r59usk02 1679 24 aspirates aspirate NNS cord-014516-r59usk02 1679 25 were be VBD cord-014516-r59usk02 1679 26 tested test VBN cord-014516-r59usk02 1679 27 for for IN cord-014516-r59usk02 1679 28 Bartonella Bartonella NNP cord-014516-r59usk02 1679 29 spp spp NNS cord-014516-r59usk02 1679 30 . . . cord-014516-r59usk02 1680 1 DNA DNA NNP cord-014516-r59usk02 1680 2 using use VBG cord-014516-r59usk02 1680 3 a a DT cord-014516-r59usk02 1680 4 Bartonella Bartonella NNP cord-014516-r59usk02 1680 5 alpha alpha NN cord-014516-r59usk02 1680 6 proteobacteria proteobacteria NN cord-014516-r59usk02 1680 7 growth growth NN cord-014516-r59usk02 1680 8 medium medium NN cord-014516-r59usk02 1680 9 ( ( -LRB- cord-014516-r59usk02 1680 10 BAP BAP NNP cord-014516-r59usk02 1680 11 - - HYPH cord-014516-r59usk02 1680 12 GM GM NNP cord-014516-r59usk02 1680 13 ) ) -RRB- cord-014516-r59usk02 1680 14 diagnostic diagnostic JJ cord-014516-r59usk02 1680 15 platform platform NN cord-014516-r59usk02 1680 16 . . . cord-014516-r59usk02 1681 1 Eight eight CD cord-014516-r59usk02 1681 2 ( ( -LRB- cord-014516-r59usk02 1681 3 21.1 21.1 CD cord-014516-r59usk02 1681 4 % % NN cord-014516-r59usk02 1681 5 ) ) -RRB- cord-014516-r59usk02 1681 6 dogs dog NNS cord-014516-r59usk02 1681 7 were be VBD cord-014516-r59usk02 1681 8 infected infect VBN cord-014516-r59usk02 1681 9 with with IN cord-014516-r59usk02 1681 10 one one CD cord-014516-r59usk02 1681 11 or or CC cord-014516-r59usk02 1681 12 two two CD cord-014516-r59usk02 1681 13 Bartonella Bartonella NNP cord-014516-r59usk02 1681 14 species specie NNS cord-014516-r59usk02 1681 15 , , , cord-014516-r59usk02 1681 16 including include VBG cord-014516-r59usk02 1681 17 Candidatus Candidatus NNP cord-014516-r59usk02 1681 18 Bartonella Bartonella NNP cord-014516-r59usk02 1681 19 merieuxii(n merieuxii(n NNP cord-014516-r59usk02 1681 20 = = SYM cord-014516-r59usk02 1681 21 5 5 CD cord-014516-r59usk02 1681 22 ) ) -RRB- cord-014516-r59usk02 1681 23 , , , cord-014516-r59usk02 1681 24 B. B. NNP cord-014516-r59usk02 1681 25 henselae henselae NNP cord-014516-r59usk02 1681 26 SA2 SA2 NNP cord-014516-r59usk02 1681 27 ( ( -LRB- cord-014516-r59usk02 1681 28 n n NN cord-014516-r59usk02 1681 29 = = SYM cord-014516-r59usk02 1681 30 3 3 CD cord-014516-r59usk02 1681 31 ) ) -RRB- cord-014516-r59usk02 1681 32 and and CC cord-014516-r59usk02 1681 33 B. B. NNP cord-014516-r59usk02 1681 34 rochalimae rochalimae NNP cord-014516-r59usk02 1681 35 ( ( -LRB- cord-014516-r59usk02 1681 36 n n NN cord-014516-r59usk02 1681 37 = = SYM cord-014516-r59usk02 1681 38 1 1 CD cord-014516-r59usk02 1681 39 ) ) -RRB- cord-014516-r59usk02 1681 40 . . . cord-014516-r59usk02 1682 1 Bartonella Bartonella NNP cord-014516-r59usk02 1682 2 spp spp NN cord-014516-r59usk02 1682 3 . . . cord-014516-r59usk02 1683 1 DNA DNA NNP cord-014516-r59usk02 1683 2 was be VBD cord-014516-r59usk02 1683 3 amplified amplify VBN cord-014516-r59usk02 1683 4 from from IN cord-014516-r59usk02 1683 5 BM BM NNP cord-014516-r59usk02 1683 6 in in IN cord-014516-r59usk02 1683 7 4 4 CD cord-014516-r59usk02 1683 8 dogs dog NNS cord-014516-r59usk02 1683 9 and and CC cord-014516-r59usk02 1683 10 from from IN cord-014516-r59usk02 1683 11 blood blood NN cord-014516-r59usk02 1683 12 in in IN cord-014516-r59usk02 1683 13 3 3 CD cord-014516-r59usk02 1683 14 dogs dog NNS cord-014516-r59usk02 1683 15 but but CC cord-014516-r59usk02 1683 16 was be VBD cord-014516-r59usk02 1683 17 not not RB cord-014516-r59usk02 1683 18 amplified amplify VBN cord-014516-r59usk02 1683 19 from from IN cord-014516-r59usk02 1683 20 any any DT cord-014516-r59usk02 1683 21 SF SF NNP cord-014516-r59usk02 1683 22 sample sample NN cord-014516-r59usk02 1683 23 . . . cord-014516-r59usk02 1684 1 Overall overall RB cord-014516-r59usk02 1684 2 , , , cord-014516-r59usk02 1684 3 6 6 CD cord-014516-r59usk02 1684 4 ( ( -LRB- cord-014516-r59usk02 1684 5 19.4 19.4 CD cord-014516-r59usk02 1684 6 % % NN cord-014516-r59usk02 1684 7 ) ) -RRB- cord-014516-r59usk02 1684 8 dogs dog NNS cord-014516-r59usk02 1684 9 with with IN cord-014516-r59usk02 1684 10 and and CC cord-014516-r59usk02 1684 11 2 2 CD cord-014516-r59usk02 1684 12 ( ( -LRB- cord-014516-r59usk02 1684 13 28.6 28.6 CD cord-014516-r59usk02 1684 14 % % NN cord-014516-r59usk02 1684 15 ) ) -RRB- cord-014516-r59usk02 1685 1 dogs dog NNS cord-014516-r59usk02 1685 2 without without IN cord-014516-r59usk02 1685 3 arthritis arthritis NN cord-014516-r59usk02 1685 4 were be VBD cord-014516-r59usk02 1685 5 infected infect VBN cord-014516-r59usk02 1685 6 with with IN cord-014516-r59usk02 1685 7 a a DT cord-014516-r59usk02 1685 8 Bartonella Bartonella NNP cord-014516-r59usk02 1685 9 species specie NNS cord-014516-r59usk02 1685 10 . . . cord-014516-r59usk02 1686 1 The the DT cord-014516-r59usk02 1686 2 prevalence prevalence NN cord-014516-r59usk02 1686 3 of of IN cord-014516-r59usk02 1686 4 Bartonella Bartonella NNP cord-014516-r59usk02 1686 5 spp spp NNS cord-014516-r59usk02 1686 6 . . . cord-014516-r59usk02 1687 1 DNA DNA NNP cord-014516-r59usk02 1687 2 in in IN cord-014516-r59usk02 1687 3 the the DT cord-014516-r59usk02 1687 4 dogs dog NNS cord-014516-r59usk02 1687 5 with with IN cord-014516-r59usk02 1687 6 or or CC cord-014516-r59usk02 1687 7 without without IN cord-014516-r59usk02 1687 8 arthritis arthritis NN cord-014516-r59usk02 1687 9 did do VBD cord-014516-r59usk02 1687 10 not not RB cord-014516-r59usk02 1687 11 differ differ VB cord-014516-r59usk02 1687 12 ( ( -LRB- cord-014516-r59usk02 1687 13 v v NN cord-014516-r59usk02 1687 14 2 2 CD cord-014516-r59usk02 1687 15 test test NN cord-014516-r59usk02 1687 16 for for IN cord-014516-r59usk02 1687 17 independence independence NN cord-014516-r59usk02 1687 18 , , , cord-014516-r59usk02 1687 19 P p NN cord-014516-r59usk02 1687 20 = = SYM cord-014516-r59usk02 1687 21 0.589 0.589 CD cord-014516-r59usk02 1688 1 The the DT cord-014516-r59usk02 1688 2 prevalence prevalence NN cord-014516-r59usk02 1688 3 of of IN cord-014516-r59usk02 1688 4 Giardia Giardia NNP cord-014516-r59usk02 1688 5 in in IN cord-014516-r59usk02 1688 6 dogs dog NNS cord-014516-r59usk02 1688 7 ranges range VBZ cord-014516-r59usk02 1688 8 between between IN cord-014516-r59usk02 1688 9 5.4 5.4 CD cord-014516-r59usk02 1688 10 % % NN cord-014516-r59usk02 1688 11 and and CC cord-014516-r59usk02 1688 12 55.2 55.2 CD cord-014516-r59usk02 1688 13 % % NN cord-014516-r59usk02 1688 14 , , , cord-014516-r59usk02 1688 15 with with IN cord-014516-r59usk02 1688 16 a a DT cord-014516-r59usk02 1688 17 higher high JJR cord-014516-r59usk02 1688 18 prevalence prevalence NN cord-014516-r59usk02 1688 19 in in IN cord-014516-r59usk02 1688 20 puppies puppy NNS cord-014516-r59usk02 1688 21 . . . cord-014516-r59usk02 1689 1 However however RB cord-014516-r59usk02 1689 2 , , , cord-014516-r59usk02 1689 3 the the DT cord-014516-r59usk02 1689 4 risk risk NN cord-014516-r59usk02 1689 5 factors factor NNS cord-014516-r59usk02 1689 6 for for IN cord-014516-r59usk02 1689 7 Giardia Giardia NNP cord-014516-r59usk02 1689 8 infection infection NN cord-014516-r59usk02 1689 9 around around IN cord-014516-r59usk02 1689 10 weaning weaning NN cord-014516-r59usk02 1689 11 have have VBP cord-014516-r59usk02 1689 12 been be VBN cord-014516-r59usk02 1689 13 poorly poorly RB cord-014516-r59usk02 1689 14 described describe VBN cord-014516-r59usk02 1689 15 . . . cord-014516-r59usk02 1690 1 The the DT cord-014516-r59usk02 1690 2 aim aim NN cord-014516-r59usk02 1690 3 of of IN cord-014516-r59usk02 1690 4 the the DT cord-014516-r59usk02 1690 5 study study NN cord-014516-r59usk02 1690 6 was be VBD cord-014516-r59usk02 1690 7 to to TO cord-014516-r59usk02 1690 8 evaluate evaluate VB cord-014516-r59usk02 1690 9 risk risk NN cord-014516-r59usk02 1690 10 factors factor NNS cord-014516-r59usk02 1690 11 for for IN cord-014516-r59usk02 1690 12 Giardia Giardia NNP cord-014516-r59usk02 1690 13 infection infection NN cord-014516-r59usk02 1690 14 in in IN cord-014516-r59usk02 1690 15 puppies puppy NNS cord-014516-r59usk02 1690 16 during during IN cord-014516-r59usk02 1690 17 the the DT cord-014516-r59usk02 1690 18 first first JJ cord-014516-r59usk02 1690 19 weeks week NNS cord-014516-r59usk02 1690 20 of of IN cord-014516-r59usk02 1690 21 life life NN cord-014516-r59usk02 1690 22 and and CC cord-014516-r59usk02 1690 23 to to TO cord-014516-r59usk02 1690 24 determine determine VB cord-014516-r59usk02 1690 25 an an DT cord-014516-r59usk02 1690 26 impact impact NN cord-014516-r59usk02 1690 27 of of IN cord-014516-r59usk02 1690 28 this this DT cord-014516-r59usk02 1690 29 parasite parasite NN cord-014516-r59usk02 1690 30 on on IN cord-014516-r59usk02 1690 31 feces fece NNS cord-014516-r59usk02 1690 32 quality quality NN cord-014516-r59usk02 1690 33 . . . cord-014516-r59usk02 1691 1 192 192 CD cord-014516-r59usk02 1691 2 puppies puppy NNS cord-014516-r59usk02 1691 3 from from IN cord-014516-r59usk02 1691 4 58 58 CD cord-014516-r59usk02 1691 5 litters litter NNS cord-014516-r59usk02 1691 6 living live VBG cord-014516-r59usk02 1691 7 in in IN cord-014516-r59usk02 1691 8 a a DT cord-014516-r59usk02 1691 9 breeding breeding NN cord-014516-r59usk02 1691 10 kennel kennel NN cord-014516-r59usk02 1691 11 were be VBD cord-014516-r59usk02 1691 12 followed follow VBN cord-014516-r59usk02 1691 13 between between IN cord-014516-r59usk02 1691 14 4 4 CD cord-014516-r59usk02 1691 15 and and CC cord-014516-r59usk02 1691 16 9 9 CD cord-014516-r59usk02 1691 17 weeks week NNS cord-014516-r59usk02 1691 18 of of IN cord-014516-r59usk02 1691 19 age age NN cord-014516-r59usk02 1691 20 . . . cord-014516-r59usk02 1692 1 Each each DT cord-014516-r59usk02 1692 2 puppy puppy NN cord-014516-r59usk02 1692 3 was be VBD cord-014516-r59usk02 1692 4 treated treat VBN cord-014516-r59usk02 1692 5 with with IN cord-014516-r59usk02 1692 6 fenbendazole fenbendazole NNP cord-014516-r59usk02 1692 7 ( ( -LRB- cord-014516-r59usk02 1692 8 Panacur Panacur NNP cord-014516-r59usk02 1692 9 â â NNP cord-014516-r59usk02 1692 10 , , , cord-014516-r59usk02 1692 11 MSD MSD NNP cord-014516-r59usk02 1692 12 , , , cord-014516-r59usk02 1692 13 France France NNP cord-014516-r59usk02 1692 14 , , , cord-014516-r59usk02 1692 15 50 50 CD cord-014516-r59usk02 1692 16 mg mg NNP cord-014516-r59usk02 1692 17 / / SYM cord-014516-r59usk02 1692 18 kg kg NNP cord-014516-r59usk02 1692 19 , , , cord-014516-r59usk02 1692 20 per per IN cord-014516-r59usk02 1692 21 os os NNP cord-014516-r59usk02 1692 22 , , , cord-014516-r59usk02 1692 23 q q NNP cord-014516-r59usk02 1692 24 24 24 CD cord-014516-r59usk02 1692 25 h h NNP cord-014516-r59usk02 1692 26 ) ) -RRB- cord-014516-r59usk02 1692 27 for for IN cord-014516-r59usk02 1692 28 3 3 CD cord-014516-r59usk02 1692 29 consecutive consecutive JJ cord-014516-r59usk02 1692 30 days day NNS cord-014516-r59usk02 1692 31 at at IN cord-014516-r59usk02 1692 32 2 2 CD cord-014516-r59usk02 1692 33 , , , cord-014516-r59usk02 1692 34 4 4 CD cord-014516-r59usk02 1692 35 , , , cord-014516-r59usk02 1692 36 6 6 CD cord-014516-r59usk02 1692 37 and and CC cord-014516-r59usk02 1692 38 8 8 CD cord-014516-r59usk02 1692 39 weeks week NNS cord-014516-r59usk02 1692 40 of of IN cord-014516-r59usk02 1692 41 age age NN cord-014516-r59usk02 1692 42 . . . cord-014516-r59usk02 1693 1 For for IN cord-014516-r59usk02 1693 2 each each DT cord-014516-r59usk02 1693 3 puppy puppy NN cord-014516-r59usk02 1693 4 , , , cord-014516-r59usk02 1693 5 fecal fecal JJ cord-014516-r59usk02 1693 6 consistency consistency NN cord-014516-r59usk02 1693 7 was be VBD cord-014516-r59usk02 1693 8 evaluated evaluate VBN cord-014516-r59usk02 1693 9 using use VBG cord-014516-r59usk02 1693 10 a a DT cord-014516-r59usk02 1693 11 13-point 13-point JJ cord-014516-r59usk02 1693 12 scale scale NN cord-014516-r59usk02 1693 13 . . . cord-014516-r59usk02 1694 1 Excretion excretion NN cord-014516-r59usk02 1694 2 of of IN cord-014516-r59usk02 1694 3 enteropathogens enteropathogen NNS cord-014516-r59usk02 1694 4 was be VBD cord-014516-r59usk02 1694 5 evaluated evaluate VBN cord-014516-r59usk02 1694 6 by by IN cord-014516-r59usk02 1694 7 qPCR qPCR NNP cord-014516-r59usk02 1694 8 for for IN cord-014516-r59usk02 1694 9 canine canine JJ cord-014516-r59usk02 1694 10 parvovirus parvovirus NN cord-014516-r59usk02 1694 11 type type NN cord-014516-r59usk02 1694 12 2 2 CD cord-014516-r59usk02 1694 13 ( ( -LRB- cord-014516-r59usk02 1694 14 CPV2 CPV2 NNP cord-014516-r59usk02 1694 15 ) ) -RRB- cord-014516-r59usk02 1694 16 , , , cord-014516-r59usk02 1694 17 qRT qRT NNP cord-014516-r59usk02 1694 18 - - HYPH cord-014516-r59usk02 1694 19 PCR PCR NNP cord-014516-r59usk02 1694 20 for for IN cord-014516-r59usk02 1694 21 canine canine JJ cord-014516-r59usk02 1694 22 coronavirus coronavirus NN cord-014516-r59usk02 1694 23 ( ( -LRB- cord-014516-r59usk02 1694 24 CCV CCV NNP cord-014516-r59usk02 1694 25 ) ) -RRB- cord-014516-r59usk02 1694 26 , , , cord-014516-r59usk02 1694 27 coproantigens coproantigens NNP cord-014516-r59usk02 1694 28 quantification quantification NN cord-014516-r59usk02 1694 29 for for IN cord-014516-r59usk02 1694 30 Giardia Giardia NNP cord-014516-r59usk02 1694 31 ( ( -LRB- cord-014516-r59usk02 1694 32 ProSpecT ProSpecT NNP cord-014516-r59usk02 1694 33 - - HYPH cord-014516-r59usk02 1694 34 Giardia Giardia NNP cord-014516-r59usk02 1694 35 , , , cord-014516-r59usk02 1694 36 Remel Remel NNP cord-014516-r59usk02 1694 37 ) ) -RRB- cord-014516-r59usk02 1694 38 , , , cord-014516-r59usk02 1694 39 and and CC cord-014516-r59usk02 1694 40 McMaster McMaster NNP cord-014516-r59usk02 1694 41 flotation flotation NN cord-014516-r59usk02 1694 42 technique technique NN cord-014516-r59usk02 1694 43 for for IN cord-014516-r59usk02 1694 44 any any DT cord-014516-r59usk02 1694 45 eggs egg NNS cord-014516-r59usk02 1694 46 and and CC cord-014516-r59usk02 1694 47 oocysts oocyst NNS cord-014516-r59usk02 1694 48 . . . cord-014516-r59usk02 1695 1 A a DT cord-014516-r59usk02 1695 2 generalized generalized JJ cord-014516-r59usk02 1695 3 linear linear JJ cord-014516-r59usk02 1695 4 mixed mixed JJ cord-014516-r59usk02 1695 5 model model NN cord-014516-r59usk02 1695 6 ( ( -LRB- cord-014516-r59usk02 1695 7 proc proc VB cord-014516-r59usk02 1695 8 GLIMMIX GLIMMIX NNP cord-014516-r59usk02 1695 9 ) ) -RRB- cord-014516-r59usk02 1695 10 with with IN cord-014516-r59usk02 1695 11 Giardia Giardia NNP cord-014516-r59usk02 1695 12 infection infection NN cord-014516-r59usk02 1695 13 as as IN cord-014516-r59usk02 1695 14 a a DT cord-014516-r59usk02 1695 15 binary binary JJ cord-014516-r59usk02 1695 16 outcome outcome NN cord-014516-r59usk02 1695 17 was be VBD cord-014516-r59usk02 1695 18 used use VBN cord-014516-r59usk02 1695 19 to to TO cord-014516-r59usk02 1695 20 assess assess VB cord-014516-r59usk02 1695 21 the the DT cord-014516-r59usk02 1695 22 following follow VBG cord-014516-r59usk02 1695 23 effects effect NNS cord-014516-r59usk02 1695 24 : : : cord-014516-r59usk02 1695 25 breed breed NN cord-014516-r59usk02 1695 26 size size NN cord-014516-r59usk02 1695 27 , , , cord-014516-r59usk02 1695 28 age age NN cord-014516-r59usk02 1695 29 , , , cord-014516-r59usk02 1695 30 and and CC cord-014516-r59usk02 1695 31 CPV2 CPV2 NNP cord-014516-r59usk02 1695 32 , , , cord-014516-r59usk02 1695 33 CCV CCV NNP cord-014516-r59usk02 1695 34 and and CC cord-014516-r59usk02 1695 35 Isospora Isospora NNP cord-014516-r59usk02 1695 36 ohioensis ohioensis NN cord-014516-r59usk02 1695 37 infections infection NNS cord-014516-r59usk02 1695 38 . . . cord-014516-r59usk02 1696 1 A a DT cord-014516-r59usk02 1696 2 linear linear JJ cord-014516-r59usk02 1696 3 mixed mixed JJ cord-014516-r59usk02 1696 4 model model NN cord-014516-r59usk02 1696 5 ( ( -LRB- cord-014516-r59usk02 1696 6 proc proc VB cord-014516-r59usk02 1696 7 MIXED MIXED NNP cord-014516-r59usk02 1696 8 ) ) -RRB- cord-014516-r59usk02 1696 9 with with IN cord-014516-r59usk02 1696 10 fecal fecal JJ cord-014516-r59usk02 1696 11 score score NN cord-014516-r59usk02 1696 12 as as IN cord-014516-r59usk02 1696 13 outcome outcome NN cord-014516-r59usk02 1696 14 was be VBD cord-014516-r59usk02 1696 15 used use VBN cord-014516-r59usk02 1696 16 to to TO cord-014516-r59usk02 1696 17 determine determine VB cord-014516-r59usk02 1696 18 the the DT cord-014516-r59usk02 1696 19 following follow VBG cord-014516-r59usk02 1696 20 effects effect NNS cord-014516-r59usk02 1696 21 : : : cord-014516-r59usk02 1696 22 breed breed NN cord-014516-r59usk02 1696 23 size size NN cord-014516-r59usk02 1696 24 , , , cord-014516-r59usk02 1696 25 age age NN cord-014516-r59usk02 1696 26 , , , cord-014516-r59usk02 1696 27 and and CC cord-014516-r59usk02 1696 28 Giardia Giardia NNP cord-014516-r59usk02 1696 29 , , , cord-014516-r59usk02 1696 30 CPV2 CPV2 NNP cord-014516-r59usk02 1696 31 , , , cord-014516-r59usk02 1696 32 CCV CCV NNP cord-014516-r59usk02 1696 33 and and CC cord-014516-r59usk02 1696 34 I. I. NNP cord-014516-r59usk02 1696 35 ohioensis ohioensis NN cord-014516-r59usk02 1696 36 infections infection NNS cord-014516-r59usk02 1696 37 . . . cord-014516-r59usk02 1697 1 A a DT cord-014516-r59usk02 1697 2 total total NN cord-014516-r59usk02 1697 3 of of IN cord-014516-r59usk02 1697 4 277 277 CD cord-014516-r59usk02 1697 5 fecal fecal JJ cord-014516-r59usk02 1697 6 samples sample NNS cord-014516-r59usk02 1697 7 were be VBD cord-014516-r59usk02 1697 8 collected collect VBN cord-014516-r59usk02 1697 9 ; ; : cord-014516-r59usk02 1697 10 CPV2 CPV2 NNP cord-014516-r59usk02 1697 11 , , , cord-014516-r59usk02 1697 12 Giardia Giardia NNP cord-014516-r59usk02 1697 13 , , , cord-014516-r59usk02 1697 14 I. I. NNP cord-014516-r59usk02 1697 15 ohioensis ohioensis NN cord-014516-r59usk02 1697 16 and and CC cord-014516-r59usk02 1697 17 CCVwere CCVwere NNP cord-014516-r59usk02 1697 18 detected detect VBN cord-014516-r59usk02 1697 19 in in IN cord-014516-r59usk02 1697 20 respectively respectively RB cord-014516-r59usk02 1697 21 13.4 13.4 CD cord-014516-r59usk02 1697 22 % % NN cord-014516-r59usk02 1697 23 , , , cord-014516-r59usk02 1697 24 17 17 CD cord-014516-r59usk02 1697 25 % % NN cord-014516-r59usk02 1697 26 , , , cord-014516-r59usk02 1697 27 30.3 30.3 CD cord-014516-r59usk02 1697 28 % % NN cord-014516-r59usk02 1697 29 and and CC cord-014516-r59usk02 1697 30 67.9 67.9 CD cord-014516-r59usk02 1697 31 % % NN cord-014516-r59usk02 1697 32 of of IN cord-014516-r59usk02 1697 33 the the DT cord-014516-r59usk02 1697 34 samples sample NNS cord-014516-r59usk02 1697 35 . . . cord-014516-r59usk02 1698 1 The the DT cord-014516-r59usk02 1698 2 risk risk NN cord-014516-r59usk02 1698 3 of of IN cord-014516-r59usk02 1698 4 Giardia Giardia NNP cord-014516-r59usk02 1698 5 infection infection NN cord-014516-r59usk02 1698 6 increased increase VBD cord-014516-r59usk02 1698 7 with with IN cord-014516-r59usk02 1698 8 age age NN cord-014516-r59usk02 1698 9 ( ( -LRB- cord-014516-r59usk02 1698 10 Odd Odd NNP cord-014516-r59usk02 1698 11 Ratio= ratio= SYM cord-014516-r59usk02 1698 12 1.5 1.5 CD cord-014516-r59usk02 1698 13 ; ; : cord-014516-r59usk02 1698 14 95%CI=1.1 95%ci=1.1 CD cord-014516-r59usk02 1698 15 - - HYPH cord-014516-r59usk02 1698 16 2.1 2.1 CD cord-014516-r59usk02 1698 17 ; ; : cord-014516-r59usk02 1698 18 p p NN cord-014516-r59usk02 1698 19 = = SYM cord-014516-r59usk02 1698 20 0.015 0.015 CD cord-014516-r59usk02 1698 21 ) ) -RRB- cord-014516-r59usk02 1698 22 . . . cord-014516-r59usk02 1699 1 Neither neither DT cord-014516-r59usk02 1699 2 breed breed NN cord-014516-r59usk02 1699 3 , , , cord-014516-r59usk02 1699 4 nor nor CC cord-014516-r59usk02 1699 5 CPV2 CPV2 NNP cord-014516-r59usk02 1699 6 , , , cord-014516-r59usk02 1699 7 CCV CCV NNP cord-014516-r59usk02 1699 8 and and CC cord-014516-r59usk02 1699 9 I. I. NNP cord-014516-r59usk02 1699 10 ohioensis ohioensis NN cord-014516-r59usk02 1699 11 infections infection NNS cord-014516-r59usk02 1699 12 influenced influence VBD cord-014516-r59usk02 1699 13 risk risk NN cord-014516-r59usk02 1699 14 of of IN cord-014516-r59usk02 1699 15 Giardia Giardia NNP cord-014516-r59usk02 1699 16 infection infection NN cord-014516-r59usk02 1700 1 ( ( -LRB- cord-014516-r59usk02 1700 2 p p NN cord-014516-r59usk02 1700 3 = = SYM cord-014516-r59usk02 1700 4 0.299 0.299 CD cord-014516-r59usk02 1700 5 ; ; : cord-014516-r59usk02 1700 6 p p NN cord-014516-r59usk02 1700 7 = = SYM cord-014516-r59usk02 1700 8 0.213 0.213 CD cord-014516-r59usk02 1700 9 ; ; : cord-014516-r59usk02 1700 10 p p NN cord-014516-r59usk02 1700 11 = = SYM cord-014516-r59usk02 1700 12 0.892 0.892 CD cord-014516-r59usk02 1700 13 ; ; : cord-014516-r59usk02 1700 14 p p NN cord-014516-r59usk02 1700 15 = = SYM cord-014516-r59usk02 1700 16 0.282 0.282 CD cord-014516-r59usk02 1700 17 respectively respectively RB cord-014516-r59usk02 1700 18 ) ) -RRB- cord-014516-r59usk02 1700 19 . . . cord-014516-r59usk02 1701 1 Giardia Giardia NNP cord-014516-r59usk02 1701 2 infection infection NN cord-014516-r59usk02 1701 3 did do VBD cord-014516-r59usk02 1701 4 not not RB cord-014516-r59usk02 1701 5 impact impact VB cord-014516-r59usk02 1701 6 feces fece NNS cord-014516-r59usk02 1701 7 quality quality NN cord-014516-r59usk02 1701 8 ( ( -LRB- cord-014516-r59usk02 1701 9 p p NN cord-014516-r59usk02 1701 10 = = SYM cord-014516-r59usk02 1701 11 0.11 0.11 CD cord-014516-r59usk02 1701 12 ) ) -RRB- cord-014516-r59usk02 1701 13 , , , cord-014516-r59usk02 1701 14 whereas whereas IN cord-014516-r59usk02 1701 15 a a DT cord-014516-r59usk02 1701 16 significant significant JJ cord-014516-r59usk02 1701 17 influence influence NN cord-014516-r59usk02 1701 18 of of IN cord-014516-r59usk02 1701 19 CPV2 CPV2 NNP cord-014516-r59usk02 1701 20 ( ( -LRB- cord-014516-r59usk02 1701 21 p p NN cord-014516-r59usk02 1701 22 < < XX cord-014516-r59usk02 1701 23 0.001 0.001 CD cord-014516-r59usk02 1701 24 ) ) -RRB- cord-014516-r59usk02 1701 25 , , , cord-014516-r59usk02 1701 26 CCV CCV NNP cord-014516-r59usk02 1701 27 infection infection NN cord-014516-r59usk02 1701 28 ( ( -LRB- cord-014516-r59usk02 1701 29 p p NN cord-014516-r59usk02 1701 30 = = SYM cord-014516-r59usk02 1701 31 0.030 0.030 CD cord-014516-r59usk02 1701 32 ) ) -RRB- cord-014516-r59usk02 1701 33 and and CC cord-014516-r59usk02 1701 34 breed breed VB cord-014516-r59usk02 1701 35 size size NN cord-014516-r59usk02 1701 36 ( ( -LRB- cord-014516-r59usk02 1701 37 p p NN cord-014516-r59usk02 1701 38 < < XX cord-014516-r59usk02 1701 39 0.001 0.001 CD cord-014516-r59usk02 1701 40 ) ) -RRB- cord-014516-r59usk02 1701 41 was be VBD cord-014516-r59usk02 1701 42 evidenced evidence VBN cord-014516-r59usk02 1701 43 . . . cord-014516-r59usk02 1702 1 This this DT cord-014516-r59usk02 1702 2 study study NN cord-014516-r59usk02 1702 3 underlines underline VBZ cord-014516-r59usk02 1702 4 that that IN cord-014516-r59usk02 1702 5 even even RB cord-014516-r59usk02 1702 6 with with IN cord-014516-r59usk02 1702 7 an an DT cord-014516-r59usk02 1702 8 adapted adapt VBN cord-014516-r59usk02 1702 9 deworming deworme VBG cord-014516-r59usk02 1702 10 program program NN cord-014516-r59usk02 1702 11 the the DT cord-014516-r59usk02 1702 12 eradication eradication NN cord-014516-r59usk02 1702 13 of of IN cord-014516-r59usk02 1702 14 Giardia Giardia NNP cord-014516-r59usk02 1702 15 is be VBZ cord-014516-r59usk02 1702 16 difficult difficult JJ cord-014516-r59usk02 1702 17 to to TO cord-014516-r59usk02 1702 18 obtain obtain VB cord-014516-r59usk02 1702 19 in in IN cord-014516-r59usk02 1702 20 large large JJ cord-014516-r59usk02 1702 21 dog dog NN cord-014516-r59usk02 1702 22 packs pack NNS cord-014516-r59usk02 1702 23 . . . cord-014516-r59usk02 1703 1 The the DT cord-014516-r59usk02 1703 2 higher high JJR cord-014516-r59usk02 1703 3 prevalence prevalence NN cord-014516-r59usk02 1703 4 of of IN cord-014516-r59usk02 1703 5 Giardia Giardia NNP cord-014516-r59usk02 1703 6 in in IN cord-014516-r59usk02 1703 7 puppies puppy NNS cord-014516-r59usk02 1703 8 of of IN cord-014516-r59usk02 1703 9 7 7 CD cord-014516-r59usk02 1703 10 weeks week NNS cord-014516-r59usk02 1703 11 and and CC cord-014516-r59usk02 1703 12 older old JJR cord-014516-r59usk02 1703 13 could could MD cord-014516-r59usk02 1703 14 be be VB cord-014516-r59usk02 1703 15 linked link VBN cord-014516-r59usk02 1703 16 with with IN cord-014516-r59usk02 1703 17 the the DT cord-014516-r59usk02 1703 18 immunity immunity NN cord-014516-r59usk02 1703 19 gap gap NN cord-014516-r59usk02 1703 20 during during IN cord-014516-r59usk02 1703 21 this this DT cord-014516-r59usk02 1703 22 period period NN cord-014516-r59usk02 1703 23 . . . cord-014516-r59usk02 1704 1 Giardia Giardia NNP cord-014516-r59usk02 1704 2 was be VBD cord-014516-r59usk02 1704 3 not not RB cord-014516-r59usk02 1704 4 associated associate VBN cord-014516-r59usk02 1704 5 in in IN cord-014516-r59usk02 1704 6 our -PRON- PRP$ cord-014516-r59usk02 1704 7 study study NN cord-014516-r59usk02 1704 8 with with IN cord-014516-r59usk02 1704 9 an an DT cord-014516-r59usk02 1704 10 increased increase VBN cord-014516-r59usk02 1704 11 risk risk NN cord-014516-r59usk02 1704 12 of of IN cord-014516-r59usk02 1704 13 diarrhea diarrhea NN cord-014516-r59usk02 1704 14 . . . cord-014516-r59usk02 1705 1 The the DT cord-014516-r59usk02 1705 2 lack lack NN cord-014516-r59usk02 1705 3 of of IN cord-014516-r59usk02 1705 4 pathogenicity pathogenicity NN cord-014516-r59usk02 1705 5 of of IN cord-014516-r59usk02 1705 6 the the DT cord-014516-r59usk02 1705 7 parasite parasite NN cord-014516-r59usk02 1705 8 per per FW cord-014516-r59usk02 1705 9 se se FW cord-014516-r59usk02 1705 10 could could MD cord-014516-r59usk02 1705 11 be be VB cord-014516-r59usk02 1705 12 hypothesized hypothesize VBN cord-014516-r59usk02 1705 13 , , , cord-014516-r59usk02 1705 14 but but CC cord-014516-r59usk02 1705 15 also also RB cord-014516-r59usk02 1705 16 an an DT cord-014516-r59usk02 1705 17 efficacy efficacy NN cord-014516-r59usk02 1705 18 of of IN cord-014516-r59usk02 1705 19 the the DT cord-014516-r59usk02 1705 20 treatment treatment NN cord-014516-r59usk02 1705 21 for for IN cord-014516-r59usk02 1705 22 the the DT cord-014516-r59usk02 1705 23 prevention prevention NN cord-014516-r59usk02 1705 24 of of IN cord-014516-r59usk02 1705 25 the the DT cord-014516-r59usk02 1705 26 clinical clinical JJ cord-014516-r59usk02 1705 27 signs sign NNS cord-014516-r59usk02 1705 28 or or CC cord-014516-r59usk02 1705 29 a a DT cord-014516-r59usk02 1705 30 local local JJ cord-014516-r59usk02 1705 31 and and CC cord-014516-r59usk02 1705 32 systemic systemic JJ cord-014516-r59usk02 1705 33 immunity immunity NN cord-014516-r59usk02 1705 34 limiting limit VBG cord-014516-r59usk02 1705 35 clinical clinical JJ cord-014516-r59usk02 1705 36 signs sign NNS cord-014516-r59usk02 1705 37 . . . cord-014516-r59usk02 1706 1 Financial financial JJ cord-014516-r59usk02 1706 2 support support NN cord-014516-r59usk02 1706 3 from from IN cord-014516-r59usk02 1706 4 Royal Royal NNP cord-014516-r59usk02 1706 5 canin canin NN cord-014516-r59usk02 1706 6 . . . cord-014516-r59usk02 1707 1 Hepatic hepatic JJ cord-014516-r59usk02 1707 2 Encephalopathy Encephalopathy NNP cord-014516-r59usk02 1707 3 ( ( -LRB- cord-014516-r59usk02 1707 4 HE he NN cord-014516-r59usk02 1707 5 ) ) -RRB- cord-014516-r59usk02 1707 6 can can MD cord-014516-r59usk02 1707 7 occur occur VB cord-014516-r59usk02 1707 8 in in IN cord-014516-r59usk02 1707 9 dogs dog NNS cord-014516-r59usk02 1707 10 as as IN cord-014516-r59usk02 1707 11 a a DT cord-014516-r59usk02 1707 12 complication complication NN cord-014516-r59usk02 1707 13 of of IN cord-014516-r59usk02 1707 14 primary primary JJ cord-014516-r59usk02 1707 15 liver liver NN cord-014516-r59usk02 1707 16 disease disease NN cord-014516-r59usk02 1707 17 or or CC cord-014516-r59usk02 1707 18 as as IN cord-014516-r59usk02 1707 19 consequence consequence NN cord-014516-r59usk02 1707 20 of of IN cord-014516-r59usk02 1707 21 congenital congenital JJ cord-014516-r59usk02 1707 22 portosystemic portosystemic JJ cord-014516-r59usk02 1707 23 shunts shunt NNS cord-014516-r59usk02 1707 24 ( ( -LRB- cord-014516-r59usk02 1707 25 PSS PSS NNP cord-014516-r59usk02 1707 26 ) ) -RRB- cord-014516-r59usk02 1707 27 . . . cord-014516-r59usk02 1708 1 The the DT cord-014516-r59usk02 1708 2 aim aim NN cord-014516-r59usk02 1708 3 of of IN cord-014516-r59usk02 1708 4 this this DT cord-014516-r59usk02 1708 5 study study NN cord-014516-r59usk02 1708 6 was be VBD cord-014516-r59usk02 1708 7 to to TO cord-014516-r59usk02 1708 8 assess assess VB cord-014516-r59usk02 1708 9 Magnetic magnetic JJ cord-014516-r59usk02 1708 10 Resonace Resonace NNP cord-014516-r59usk02 1708 11 Spectroscopy Spectroscopy NNP cord-014516-r59usk02 1708 12 ( ( -LRB- cord-014516-r59usk02 1708 13 MRS MRS NNP cord-014516-r59usk02 1708 14 ) ) -RRB- cord-014516-r59usk02 1708 15 usefulness usefulness NN cord-014516-r59usk02 1708 16 in in IN cord-014516-r59usk02 1708 17 HE HE NNP cord-014516-r59usk02 1708 18 diagnosis diagnosis NN cord-014516-r59usk02 1708 19 . . . cord-014516-r59usk02 1709 1 Twenty twenty CD cord-014516-r59usk02 1709 2 dogs dog NNS cord-014516-r59usk02 1709 3 with with IN cord-014516-r59usk02 1709 4 a a DT cord-014516-r59usk02 1709 5 presumptive presumptive JJ cord-014516-r59usk02 1709 6 diagnosis diagnosis NN cord-014516-r59usk02 1709 7 of of IN cord-014516-r59usk02 1709 8 HE he PRP cord-014516-r59usk02 1709 9 were be VBD cord-014516-r59usk02 1709 10 enrolled enrol VBN cord-014516-r59usk02 1709 11 . . . cord-014516-r59usk02 1710 1 Inclusion inclusion NN cord-014516-r59usk02 1710 2 criteria criterion NNS cord-014516-r59usk02 1710 3 were be VBD cord-014516-r59usk02 1710 4 : : : cord-014516-r59usk02 1710 5 a a DT cord-014516-r59usk02 1710 6 clinical clinical JJ cord-014516-r59usk02 1710 7 examination examination NN cord-014516-r59usk02 1710 8 , , , cord-014516-r59usk02 1710 9 a a DT cord-014516-r59usk02 1710 10 blood blood NN cord-014516-r59usk02 1710 11 cell cell NN cord-014516-r59usk02 1710 12 count count NN cord-014516-r59usk02 1710 13 and and CC cord-014516-r59usk02 1710 14 biochemical biochemical JJ cord-014516-r59usk02 1710 15 panel panel NN cord-014516-r59usk02 1710 16 , , , cord-014516-r59usk02 1710 17 at at RB cord-014516-r59usk02 1710 18 least least RBS cord-014516-r59usk02 1710 19 one one CD cord-014516-r59usk02 1710 20 plasmatic plasmatic JJ cord-014516-r59usk02 1710 21 ammonia ammonia NN cord-014516-r59usk02 1710 22 determination determination NN cord-014516-r59usk02 1711 1 higher high JJR cord-014516-r59usk02 1711 2 than than IN cord-014516-r59usk02 1711 3 100 100 CD cord-014516-r59usk02 1711 4 lmol lmol JJ cord-014516-r59usk02 1711 5 / / SYM cord-014516-r59usk02 1711 6 L L NNP cord-014516-r59usk02 1711 7 , , , cord-014516-r59usk02 1711 8 optional optional JJ cord-014516-r59usk02 1711 9 hystopatology hystopatology NN cord-014516-r59usk02 1711 10 of of IN cord-014516-r59usk02 1711 11 the the DT cord-014516-r59usk02 1711 12 liver liver NN cord-014516-r59usk02 1711 13 , , , cord-014516-r59usk02 1711 14 requirement requirement NN cord-014516-r59usk02 1711 15 of of IN cord-014516-r59usk02 1711 16 Magnetic Magnetic NNP cord-014516-r59usk02 1711 17 Resonance Resonance NNP cord-014516-r59usk02 1711 18 Imaging Imaging NNP cord-014516-r59usk02 1711 19 ( ( -LRB- cord-014516-r59usk02 1711 20 MRI MRI NNP cord-014516-r59usk02 1711 21 ) ) -RRB- cord-014516-r59usk02 1711 22 investigation investigation NN cord-014516-r59usk02 1711 23 by by IN cord-014516-r59usk02 1711 24 the the DT cord-014516-r59usk02 1711 25 clinician clinician NN cord-014516-r59usk02 1711 26 . . . cord-014516-r59usk02 1712 1 Even even RB cord-014516-r59usk02 1712 2 though though IN cord-014516-r59usk02 1712 3 MRS MRS NNP cord-014516-r59usk02 1712 4 represents represent VBZ cord-014516-r59usk02 1712 5 a a DT cord-014516-r59usk02 1712 6 non non JJ cord-014516-r59usk02 1712 7 - - JJ cord-014516-r59usk02 1712 8 invasive invasive JJ cord-014516-r59usk02 1712 9 procedure procedure NN cord-014516-r59usk02 1712 10 , , , cord-014516-r59usk02 1712 11 informed informed JJ cord-014516-r59usk02 1712 12 consent consent NN cord-014516-r59usk02 1712 13 was be VBD cord-014516-r59usk02 1712 14 obtained obtain VBN cord-014516-r59usk02 1712 15 from from IN cord-014516-r59usk02 1712 16 dogs'owners dogs'owner NNS cord-014516-r59usk02 1712 17 . . . cord-014516-r59usk02 1713 1 HE HE NNP cord-014516-r59usk02 1713 2 diagnosis diagnosis NN cord-014516-r59usk02 1713 3 was be VBD cord-014516-r59usk02 1713 4 confirmed confirm VBN cord-014516-r59usk02 1713 5 in in IN cord-014516-r59usk02 1713 6 20/20 20/20 CD cord-014516-r59usk02 1713 7 : : : cord-014516-r59usk02 1713 8 16/20 16/20 CD cord-014516-r59usk02 1713 9 had have VBD cord-014516-r59usk02 1713 10 a a DT cord-014516-r59usk02 1713 11 PSS PSS NNP cord-014516-r59usk02 1713 12 , , , cord-014516-r59usk02 1713 13 3/20 3/20 CD cord-014516-r59usk02 1713 14 showed show VBD cord-014516-r59usk02 1713 15 hepatic hepatic JJ cord-014516-r59usk02 1713 16 microvascular microvascular JJ cord-014516-r59usk02 1713 17 dysplasia dysplasia NN cord-014516-r59usk02 1713 18 and and CC cord-014516-r59usk02 1713 19 1/20 1/20 CD cord-014516-r59usk02 1713 20 had have VBD cord-014516-r59usk02 1713 21 hepatic hepatic JJ cord-014516-r59usk02 1713 22 cirrhosis cirrhosi NNS cord-014516-r59usk02 1713 23 histologically histologically RB cord-014516-r59usk02 1713 24 confirmed confirm VBD cord-014516-r59usk02 1713 25 . . . cord-014516-r59usk02 1714 1 The the DT cord-014516-r59usk02 1714 2 control control NN cord-014516-r59usk02 1714 3 - - HYPH cord-014516-r59usk02 1714 4 group group NN cord-014516-r59usk02 1714 5 was be VBD cord-014516-r59usk02 1714 6 made make VBN cord-014516-r59usk02 1714 7 of of IN cord-014516-r59usk02 1714 8 23 23 CD cord-014516-r59usk02 1714 9 patients patient NNS cord-014516-r59usk02 1714 10 retrieved retrieve VBN cord-014516-r59usk02 1714 11 from from IN cord-014516-r59usk02 1714 12 our -PRON- PRP$ cord-014516-r59usk02 1714 13 database database NN cord-014516-r59usk02 1714 14 that that WDT cord-014516-r59usk02 1714 15 underwent undergo VBD cord-014516-r59usk02 1714 16 MRI MRI NNP cord-014516-r59usk02 1714 17 without without IN cord-014516-r59usk02 1714 18 showing show VBG cord-014516-r59usk02 1714 19 any any DT cord-014516-r59usk02 1714 20 abnormalities abnormality NNS cord-014516-r59usk02 1714 21 on on IN cord-014516-r59usk02 1714 22 brain brain NN cord-014516-r59usk02 1714 23 scans scan NNS cord-014516-r59usk02 1714 24 . . . cord-014516-r59usk02 1715 1 The the DT cord-014516-r59usk02 1715 2 MR MR NNP cord-014516-r59usk02 1715 3 protocol protocol NN cord-014516-r59usk02 1715 4 included include VBD cord-014516-r59usk02 1715 5 T2-weighted t2-weighte VBN cord-014516-r59usk02 1715 6 fast fast JJ cord-014516-r59usk02 1715 7 spin spin NN cord-014516-r59usk02 1715 8 - - HYPH cord-014516-r59usk02 1715 9 echo echo NN cord-014516-r59usk02 1715 10 , , , cord-014516-r59usk02 1715 11 T1-weighted t1-weighte VBN cord-014516-r59usk02 1715 12 sequences sequence NNS cord-014516-r59usk02 1715 13 , , , cord-014516-r59usk02 1715 14 Proton Proton NNP cord-014516-r59usk02 1715 15 Density Density NNP cord-014516-r59usk02 1715 16 , , , cord-014516-r59usk02 1715 17 and and CC cord-014516-r59usk02 1715 18 Radio radio NN cord-014516-r59usk02 1715 19 - - HYPH cord-014516-r59usk02 1715 20 frequency frequency NN cord-014516-r59usk02 1715 21 pulses pulse VBZ cord-014516-r59usk02 1715 22 Gradient gradient NN cord-014516-r59usk02 1715 23 - - HYPH cord-014516-r59usk02 1715 24 Echo Echo NNP cord-014516-r59usk02 1715 25 . . . cord-014516-r59usk02 1716 1 On on IN cord-014516-r59usk02 1716 2 MRI MRI NNP cord-014516-r59usk02 1716 3 examination examination NN cord-014516-r59usk02 1716 4 cerebral cerebral JJ cord-014516-r59usk02 1716 5 atrophy atrophy NN cord-014516-r59usk02 1716 6 was be VBD cord-014516-r59usk02 1716 7 evident evident JJ cord-014516-r59usk02 1716 8 in in IN cord-014516-r59usk02 1716 9 all all PDT cord-014516-r59usk02 1716 10 the the DT cord-014516-r59usk02 1716 11 patients patient NNS cord-014516-r59usk02 1716 12 ( ( -LRB- cord-014516-r59usk02 1716 13 20/20 20/20 CD cord-014516-r59usk02 1716 14 ) ) -RRB- cord-014516-r59usk02 1716 15 , , , cord-014516-r59usk02 1716 16 ranged range VBD cord-014516-r59usk02 1716 17 from from IN cord-014516-r59usk02 1716 18 mild mild JJ cord-014516-r59usk02 1716 19 to to IN cord-014516-r59usk02 1716 20 severe severe JJ cord-014516-r59usk02 1716 21 . . . cord-014516-r59usk02 1717 1 In in IN cord-014516-r59usk02 1717 2 17/20 17/20 CD cord-014516-r59usk02 1717 3 patients patient NNS cord-014516-r59usk02 1717 4 symmetrical symmetrical JJ cord-014516-r59usk02 1717 5 bilateral bilateral JJ cord-014516-r59usk02 1717 6 hyperintensities hyperintensitie NNS cord-014516-r59usk02 1717 7 in in IN cord-014516-r59usk02 1717 8 the the DT cord-014516-r59usk02 1717 9 globus globus NNP cord-014516-r59usk02 1717 10 pallidus pallidus NNP cord-014516-r59usk02 1717 11 on on IN cord-014516-r59usk02 1717 12 T1-weighted t1-weighte VBN cord-014516-r59usk02 1717 13 images image NNS cord-014516-r59usk02 1717 14 were be VBD cord-014516-r59usk02 1717 15 evident evident JJ cord-014516-r59usk02 1717 16 . . . cord-014516-r59usk02 1718 1 MRS MRS NNP cord-014516-r59usk02 1718 2 was be VBD cord-014516-r59usk02 1718 3 performed perform VBN cord-014516-r59usk02 1718 4 using use VBG cord-014516-r59usk02 1718 5 a a DT cord-014516-r59usk02 1718 6 short short JJ cord-014516-r59usk02 1718 7 TE TE NNP cord-014516-r59usk02 1718 8 ( ( -LRB- cord-014516-r59usk02 1718 9 30 30 CD cord-014516-r59usk02 1718 10 ms ms NNP cord-014516-r59usk02 1718 11 ) ) -RRB- cord-014516-r59usk02 1718 12 and and CC cord-014516-r59usk02 1718 13 it -PRON- PRP cord-014516-r59usk02 1718 14 was be VBD cord-014516-r59usk02 1718 15 defined define VBN cord-014516-r59usk02 1718 16 a a DT cord-014516-r59usk02 1718 17 volume volume NN cord-014516-r59usk02 1718 18 of of IN cord-014516-r59usk02 1718 19 interest interest NN cord-014516-r59usk02 1718 20 in in IN cord-014516-r59usk02 1718 21 the the DT cord-014516-r59usk02 1718 22 parieto parieto NNP cord-014516-r59usk02 1718 23 - - HYPH cord-014516-r59usk02 1718 24 occipital occipital JJ cord-014516-r59usk02 1718 25 region region NN cord-014516-r59usk02 1718 26 by by IN cord-014516-r59usk02 1718 27 10-mm 10-mm CD cord-014516-r59usk02 1718 28 side side NN cord-014516-r59usk02 1718 29 cube cube NN cord-014516-r59usk02 1718 30 ( ( -LRB- cord-014516-r59usk02 1718 31 1 1 CD cord-014516-r59usk02 1718 32 cc cc NN cord-014516-r59usk02 1718 33 of of IN cord-014516-r59usk02 1718 34 volume volume NN cord-014516-r59usk02 1718 35 ) ) -RRB- cord-014516-r59usk02 1718 36 . . . cord-014516-r59usk02 1719 1 Glutamine glutamine NN cord-014516-r59usk02 1719 2 - - HYPH cord-014516-r59usk02 1719 3 glutamate glutamate NN cord-014516-r59usk02 1719 4 ( ( -LRB- cord-014516-r59usk02 1719 5 Gln Gln NNP cord-014516-r59usk02 1719 6 ) ) -RRB- cord-014516-r59usk02 1719 7 , , , cord-014516-r59usk02 1719 8 N n CD cord-014516-r59usk02 1719 9 - - HYPH cord-014516-r59usk02 1719 10 acetylaspartate acetylaspartate NNP cord-014516-r59usk02 1719 11 and and CC cord-014516-r59usk02 1719 12 N N NNP cord-014516-r59usk02 1719 13 - - HYPH cord-014516-r59usk02 1719 14 acetyl acetyl NNP cord-014516-r59usk02 1719 15 aspartyl aspartyl NNP cord-014516-r59usk02 1719 16 glutamate glutamate NN cord-014516-r59usk02 1719 17 ( ( -LRB- cord-014516-r59usk02 1719 18 NAA NAA NNP cord-014516-r59usk02 1719 19 ) ) -RRB- cord-014516-r59usk02 1719 20 , , , cord-014516-r59usk02 1719 21 Choline choline NN cord-014516-r59usk02 1719 22 derivatives derivative NNS cord-014516-r59usk02 1719 23 ( ( -LRB- cord-014516-r59usk02 1719 24 Cho Cho NNP cord-014516-r59usk02 1719 25 ) ) -RRB- cord-014516-r59usk02 1719 26 , , , cord-014516-r59usk02 1719 27 and and CC cord-014516-r59usk02 1719 28 Myo Myo NNP cord-014516-r59usk02 1719 29 - - HYPH cord-014516-r59usk02 1719 30 Inositol Inositol NNP cord-014516-r59usk02 1719 31 ( ( -LRB- cord-014516-r59usk02 1719 32 Ins Ins NNP cord-014516-r59usk02 1719 33 ) ) -RRB- cord-014516-r59usk02 1719 34 were be VBD cord-014516-r59usk02 1719 35 analyzed analyze VBN cord-014516-r59usk02 1719 36 . . . cord-014516-r59usk02 1720 1 Comparing compare VBG cord-014516-r59usk02 1720 2 spectra spectrum NNS cord-014516-r59usk02 1720 3 from from IN cord-014516-r59usk02 1720 4 the the DT cord-014516-r59usk02 1720 5 HE HE NNP cord-014516-r59usk02 1720 6 affected affect VBD cord-014516-r59usk02 1720 7 dogs dog NNS cord-014516-r59usk02 1720 8 with with IN cord-014516-r59usk02 1720 9 those those DT cord-014516-r59usk02 1720 10 from from IN cord-014516-r59usk02 1720 11 the the DT cord-014516-r59usk02 1720 12 control control NN cord-014516-r59usk02 1720 13 - - HYPH cord-014516-r59usk02 1720 14 group group NN cord-014516-r59usk02 1720 15 decreased decrease VBD cord-014516-r59usk02 1720 16 values value NNS cord-014516-r59usk02 1720 17 of of IN cord-014516-r59usk02 1720 18 Ins Ins NNP cord-014516-r59usk02 1720 19 , , , cord-014516-r59usk02 1720 20 Cho Cho NNP cord-014516-r59usk02 1720 21 , , , cord-014516-r59usk02 1720 22 NAA NAA NNP cord-014516-r59usk02 1720 23 as as RB cord-014516-r59usk02 1720 24 well well RB cord-014516-r59usk02 1720 25 as as IN cord-014516-r59usk02 1720 26 High high JJ cord-014516-r59usk02 1720 27 field field NN cord-014516-r59usk02 1720 28 MRI mri NN cord-014516-r59usk02 1720 29 combined combine VBN cord-014516-r59usk02 1720 30 with with IN cord-014516-r59usk02 1720 31 brain brain NN cord-014516-r59usk02 1720 32 MRS MRS NNP cord-014516-r59usk02 1720 33 provide provide VBP cord-014516-r59usk02 1720 34 accurate accurate JJ cord-014516-r59usk02 1720 35 and and CC cord-014516-r59usk02 1720 36 non non JJ cord-014516-r59usk02 1720 37 - - JJ cord-014516-r59usk02 1720 38 invasive invasive JJ cord-014516-r59usk02 1720 39 diagnosis diagnosis NN cord-014516-r59usk02 1720 40 of of IN cord-014516-r59usk02 1720 41 canine canine NN cord-014516-r59usk02 1720 42 HE HE NNP cord-014516-r59usk02 1720 43 . . . cord-014516-r59usk02 1721 1 In in IN cord-014516-r59usk02 1721 2 accordance accordance NN cord-014516-r59usk02 1721 3 with with IN cord-014516-r59usk02 1721 4 human human JJ cord-014516-r59usk02 1721 5 medicine medicine NN cord-014516-r59usk02 1721 6 publications publication NNS cord-014516-r59usk02 1721 7 , , , cord-014516-r59usk02 1721 8 it -PRON- PRP cord-014516-r59usk02 1721 9 could could MD cord-014516-r59usk02 1721 10 be be VB cord-014516-r59usk02 1721 11 state state NN cord-014516-r59usk02 1721 12 that that IN cord-014516-r59usk02 1721 13 MRS MRS NNP cord-014516-r59usk02 1721 14 has have VBZ cord-014516-r59usk02 1721 15 a a DT cord-014516-r59usk02 1721 16 role role NN cord-014516-r59usk02 1721 17 in in IN cord-014516-r59usk02 1721 18 HE HE NNP cord-014516-r59usk02 1721 19 diagnosis diagnosis NN cord-014516-r59usk02 1721 20 and and CC cord-014516-r59usk02 1721 21 follow follow NN cord-014516-r59usk02 1721 22 - - HYPH cord-014516-r59usk02 1721 23 up up NN cord-014516-r59usk02 1721 24 with with IN cord-014516-r59usk02 1721 25 particular particular JJ cord-014516-r59usk02 1721 26 mention mention NN cord-014516-r59usk02 1721 27 monitoring monitoring NN cord-014516-r59usk02 1721 28 . . . cord-014516-r59usk02 1722 1 No no DT cord-014516-r59usk02 1722 2 conflicts conflict NNS cord-014516-r59usk02 1722 3 of of IN cord-014516-r59usk02 1722 4 interest interest NN cord-014516-r59usk02 1722 5 reported report VBN cord-014516-r59usk02 1722 6 . . . cord-014516-r59usk02 1723 1 Diagnosis diagnosis NN cord-014516-r59usk02 1723 2 of of IN cord-014516-r59usk02 1723 3 hepatobiliary hepatobiliary JJ cord-014516-r59usk02 1723 4 diseases disease NNS cord-014516-r59usk02 1723 5 often often RB cord-014516-r59usk02 1723 6 requires require VBZ cord-014516-r59usk02 1723 7 hepatic hepatic JJ cord-014516-r59usk02 1723 8 tissue tissue NN cord-014516-r59usk02 1723 9 sampling sampling NN cord-014516-r59usk02 1723 10 for for IN cord-014516-r59usk02 1723 11 histologic histologic JJ cord-014516-r59usk02 1723 12 evaluation evaluation NN cord-014516-r59usk02 1723 13 . . . cord-014516-r59usk02 1724 1 The the DT cord-014516-r59usk02 1724 2 laparoscopic laparoscopic JJ cord-014516-r59usk02 1724 3 technique technique NN cord-014516-r59usk02 1724 4 is be VBZ cord-014516-r59usk02 1724 5 a a DT cord-014516-r59usk02 1724 6 safe safe JJ cord-014516-r59usk02 1724 7 method method NN cord-014516-r59usk02 1724 8 and and CC cord-014516-r59usk02 1724 9 allows allow VBZ cord-014516-r59usk02 1724 10 acquisition acquisition NN cord-014516-r59usk02 1724 11 of of IN cord-014516-r59usk02 1724 12 tissue tissue NN cord-014516-r59usk02 1724 13 by by IN cord-014516-r59usk02 1724 14 wedge wedge NN cord-014516-r59usk02 1724 15 and and CC cord-014516-r59usk02 1724 16 needle needle NN cord-014516-r59usk02 1724 17 biopsies biopsy NNS cord-014516-r59usk02 1724 18 from from IN cord-014516-r59usk02 1724 19 different different JJ cord-014516-r59usk02 1724 20 liver liver NN cord-014516-r59usk02 1724 21 lobes lobe NNS cord-014516-r59usk02 1724 22 in in IN cord-014516-r59usk02 1724 23 a a DT cord-014516-r59usk02 1724 24 minimally minimally RB cord-014516-r59usk02 1724 25 invasive invasive JJ cord-014516-r59usk02 1724 26 way way NN cord-014516-r59usk02 1724 27 . . . cord-014516-r59usk02 1725 1 Specimens specimen NNS cord-014516-r59usk02 1725 2 obtained obtain VBN cord-014516-r59usk02 1725 3 with with IN cord-014516-r59usk02 1725 4 an an DT cord-014516-r59usk02 1725 5 18-gauge 18-gauge CD cord-014516-r59usk02 1725 6 biopsy biopsy JJ cord-014516-r59usk02 1725 7 needle needle NN cord-014516-r59usk02 1725 8 must must MD cord-014516-r59usk02 1725 9 be be VB cord-014516-r59usk02 1725 10 interpreted interpret VBN cord-014516-r59usk02 1725 11 with with IN cord-014516-r59usk02 1725 12 caution caution NN cord-014516-r59usk02 1725 13 due due IN cord-014516-r59usk02 1725 14 to to IN cord-014516-r59usk02 1725 15 considerable considerable JJ cord-014516-r59usk02 1725 16 variability variability NN cord-014516-r59usk02 1725 17 in in IN cord-014516-r59usk02 1725 18 tissue tissue NN cord-014516-r59usk02 1725 19 involvement involvement NN cord-014516-r59usk02 1725 20 with with IN cord-014516-r59usk02 1725 21 certain certain JJ cord-014516-r59usk02 1725 22 disease disease NN cord-014516-r59usk02 1725 23 processes process NNS cord-014516-r59usk02 1725 24 . . . cord-014516-r59usk02 1726 1 We -PRON- PRP cord-014516-r59usk02 1726 2 hypothesized hypothesize VBD cord-014516-r59usk02 1726 3 that that IN cord-014516-r59usk02 1726 4 needle needle NN cord-014516-r59usk02 1726 5 biopsy biopsy NN cord-014516-r59usk02 1726 6 specimens specimen NNS cord-014516-r59usk02 1726 7 would would MD cord-014516-r59usk02 1726 8 produce produce VB cord-014516-r59usk02 1726 9 findings finding NNS cord-014516-r59usk02 1726 10 divergent divergent JJ cord-014516-r59usk02 1726 11 from from IN cord-014516-r59usk02 1726 12 those those DT cord-014516-r59usk02 1726 13 produced produce VBN cord-014516-r59usk02 1726 14 by by IN cord-014516-r59usk02 1726 15 wedge wedge NN cord-014516-r59usk02 1726 16 biopsy biopsy NN cord-014516-r59usk02 1726 17 specimens specimen NNS cord-014516-r59usk02 1726 18 . . . cord-014516-r59usk02 1727 1 The the DT cord-014516-r59usk02 1727 2 goal goal NN cord-014516-r59usk02 1727 3 of of IN cord-014516-r59usk02 1727 4 the the DT cord-014516-r59usk02 1727 5 study study NN cord-014516-r59usk02 1727 6 was be VBD cord-014516-r59usk02 1727 7 to to TO cord-014516-r59usk02 1727 8 compare compare VB cord-014516-r59usk02 1727 9 histological histological JJ cord-014516-r59usk02 1727 10 findings finding NNS cord-014516-r59usk02 1727 11 from from IN cord-014516-r59usk02 1727 12 two two CD cord-014516-r59usk02 1727 13 laparoscopic laparoscopic JJ cord-014516-r59usk02 1727 14 biopsy biopsy NN cord-014516-r59usk02 1727 15 methods method NNS cord-014516-r59usk02 1727 16 ( ( -LRB- cord-014516-r59usk02 1727 17 wedge wedge NN cord-014516-r59usk02 1727 18 and and CC cord-014516-r59usk02 1727 19 needle needle NN cord-014516-r59usk02 1727 20 ) ) -RRB- cord-014516-r59usk02 1727 21 and and CC cord-014516-r59usk02 1727 22 assess assess VB cord-014516-r59usk02 1727 23 which which WDT cord-014516-r59usk02 1727 24 sampling sample VBG cord-014516-r59usk02 1727 25 technic technic NN cord-014516-r59usk02 1727 26 can can MD cord-014516-r59usk02 1727 27 represent represent VB cord-014516-r59usk02 1727 28 the the DT cord-014516-r59usk02 1727 29 overall overall JJ cord-014516-r59usk02 1727 30 disease disease NN cord-014516-r59usk02 1727 31 process process NN cord-014516-r59usk02 1727 32 . . . cord-014516-r59usk02 1728 1 Procedure procedure NN cord-014516-r59usk02 1728 2 : : : cord-014516-r59usk02 1729 1 All all DT cord-014516-r59usk02 1729 2 dogs dog NNS cord-014516-r59usk02 1729 3 included include VBN cord-014516-r59usk02 1729 4 in in IN cord-014516-r59usk02 1729 5 this this DT cord-014516-r59usk02 1729 6 prospective prospective JJ cord-014516-r59usk02 1729 7 study study NN cord-014516-r59usk02 1729 8 study study NN cord-014516-r59usk02 1729 9 were be VBD cord-014516-r59usk02 1729 10 suspected suspect VBN cord-014516-r59usk02 1729 11 diffuse diffuse JJ cord-014516-r59usk02 1729 12 hepatic hepatic JJ cord-014516-r59usk02 1729 13 disease disease NN cord-014516-r59usk02 1729 14 and and CC cord-014516-r59usk02 1729 15 underwent undergo VBD cord-014516-r59usk02 1729 16 laparo laparo NNP cord-014516-r59usk02 1729 17 - - HYPH cord-014516-r59usk02 1729 18 scopic scopic NNP cord-014516-r59usk02 1729 19 hepatic hepatic JJ cord-014516-r59usk02 1729 20 biopsy biopsy NN cord-014516-r59usk02 1729 21 ( ( -LRB- cord-014516-r59usk02 1729 22 wedge wedge NN cord-014516-r59usk02 1729 23 and and CC cord-014516-r59usk02 1729 24 needle needle NN cord-014516-r59usk02 1729 25 14 14 CD cord-014516-r59usk02 1729 26 - - SYM cord-014516-r59usk02 1729 27 16 16 CD cord-014516-r59usk02 1729 28 G g NN cord-014516-r59usk02 1729 29 ) ) -RRB- cord-014516-r59usk02 1729 30 between between IN cord-014516-r59usk02 1729 31 2012 2012 CD cord-014516-r59usk02 1729 32 and and CC cord-014516-r59usk02 1729 33 2014 2014 CD cord-014516-r59usk02 1729 34 . . . cord-014516-r59usk02 1730 1 All all DT cord-014516-r59usk02 1730 2 biopsy biopsy NN cord-014516-r59usk02 1730 3 specimens specimen NNS cord-014516-r59usk02 1730 4 were be VBD cord-014516-r59usk02 1730 5 examined examine VBN cord-014516-r59usk02 1730 6 on on IN cord-014516-r59usk02 1730 7 the the DT cord-014516-r59usk02 1730 8 basis basis NN cord-014516-r59usk02 1730 9 of of IN cord-014516-r59usk02 1730 10 morphologic morphologic JJ cord-014516-r59usk02 1730 11 criteria criterion NNS cord-014516-r59usk02 1730 12 and and CC cord-014516-r59usk02 1730 13 a a DT cord-014516-r59usk02 1730 14 comparison comparison NN cord-014516-r59usk02 1730 15 was be VBD cord-014516-r59usk02 1730 16 made make VBN cord-014516-r59usk02 1730 17 between between IN cord-014516-r59usk02 1730 18 the the DT cord-014516-r59usk02 1730 19 two two CD cord-014516-r59usk02 1730 20 types type NNS cord-014516-r59usk02 1730 21 of of IN cord-014516-r59usk02 1730 22 biopsies biopsy NNS cord-014516-r59usk02 1730 23 procedures procedure NNS cord-014516-r59usk02 1730 24 according accord VBG cord-014516-r59usk02 1730 25 to to IN cord-014516-r59usk02 1730 26 WSAVA WSAVA NNP cord-014516-r59usk02 1730 27 Liver Liver NNP cord-014516-r59usk02 1730 28 Standardization Standardization NNP cord-014516-r59usk02 1730 29 Group Group NNP cord-014516-r59usk02 1730 30 morphologic morphologic JJ cord-014516-r59usk02 1730 31 criteria criterion NNS cord-014516-r59usk02 1730 32 . . . cord-014516-r59usk02 1731 1 Results result NNS cord-014516-r59usk02 1731 2 : : : cord-014516-r59usk02 1732 1 Twenty twenty CD cord-014516-r59usk02 1732 2 - - HYPH cord-014516-r59usk02 1732 3 two two CD cord-014516-r59usk02 1732 4 dogs dog NNS cord-014516-r59usk02 1732 5 were be VBD cord-014516-r59usk02 1732 6 included include VBN cord-014516-r59usk02 1732 7 . . . cord-014516-r59usk02 1733 1 No no DT cord-014516-r59usk02 1733 2 complications complication NNS cord-014516-r59usk02 1733 3 were be VBD cord-014516-r59usk02 1733 4 reported report VBN cord-014516-r59usk02 1733 5 during during IN cord-014516-r59usk02 1733 6 the the DT cord-014516-r59usk02 1733 7 laparoscopic laparoscopic JJ cord-014516-r59usk02 1733 8 procedure procedure NN cord-014516-r59usk02 1733 9 . . . cord-014516-r59usk02 1734 1 The the DT cord-014516-r59usk02 1734 2 median median JJ cord-014516-r59usk02 1734 3 number number NN cord-014516-r59usk02 1734 4 of of IN cord-014516-r59usk02 1734 5 portal portal JJ cord-014516-r59usk02 1734 6 triads triad NNS cord-014516-r59usk02 1734 7 per per IN cord-014516-r59usk02 1734 8 needle needle NN cord-014516-r59usk02 1734 9 biopsy biopsy NN cord-014516-r59usk02 1734 10 specimen specimen NN cord-014516-r59usk02 1734 11 was be VBD cord-014516-r59usk02 1734 12 6 6 CD cord-014516-r59usk02 1735 1 ( ( -LRB- cord-014516-r59usk02 1735 2 range range NN cord-014516-r59usk02 1735 3 , , , cord-014516-r59usk02 1735 4 4 4 CD cord-014516-r59usk02 1735 5 to to TO cord-014516-r59usk02 1735 6 8) 8) NN cord-014516-r59usk02 1735 7 compared compare VBN cord-014516-r59usk02 1735 8 to to IN cord-014516-r59usk02 1735 9 20 20 CD cord-014516-r59usk02 1735 10 ( ( -LRB- cord-014516-r59usk02 1735 11 range range NN cord-014516-r59usk02 1735 12 14;25 14;25 CD cord-014516-r59usk02 1735 13 ) ) -RRB- cord-014516-r59usk02 1735 14 with with IN cord-014516-r59usk02 1735 15 wedge wedge NN cord-014516-r59usk02 1735 16 biopsy biopsy NN cord-014516-r59usk02 1735 17 specimen specimen NN cord-014516-r59usk02 1735 18 . . . cord-014516-r59usk02 1736 1 The the DT cord-014516-r59usk02 1736 2 median median JJ cord-014516-r59usk02 1736 3 length length NN cord-014516-r59usk02 1736 4 of of IN cord-014516-r59usk02 1736 5 needle needle NN cord-014516-r59usk02 1736 6 biopsy biopsy NN cord-014516-r59usk02 1736 7 specimens specimen NNS cord-014516-r59usk02 1736 8 was be VBD cord-014516-r59usk02 1736 9 10 10 CD cord-014516-r59usk02 1736 10 mm mm NNS cord-014516-r59usk02 1736 11 ; ; , cord-014516-r59usk02 1736 12 ( ( -LRB- cord-014516-r59usk02 1736 13 range range NN cord-014516-r59usk02 1736 14 , , , cord-014516-r59usk02 1736 15 6 6 CD cord-014516-r59usk02 1736 16 to to TO cord-014516-r59usk02 1736 17 16 16 CD cord-014516-r59usk02 1736 18 mm mm NN cord-014516-r59usk02 1736 19 ) ) -RRB- cord-014516-r59usk02 1736 20 and and CC cord-014516-r59usk02 1736 21 6 6 CD cord-014516-r59usk02 1736 22 mm mm NNS cord-014516-r59usk02 1736 23 for for IN cord-014516-r59usk02 1736 24 all all DT cord-014516-r59usk02 1736 25 wedge wedge NN cord-014516-r59usk02 1736 26 biopsies biopsy NNS cord-014516-r59usk02 1736 27 . . . cord-014516-r59usk02 1737 1 On on IN cord-014516-r59usk02 1737 2 the the DT cord-014516-r59usk02 1737 3 basis basis NN cord-014516-r59usk02 1737 4 of of IN cord-014516-r59usk02 1737 5 biopsy biopsy NN cord-014516-r59usk02 1737 6 interpretation interpretation NN cord-014516-r59usk02 1737 7 , , , cord-014516-r59usk02 1737 8 the the DT cord-014516-r59usk02 1737 9 diagnosis diagnosis NN cord-014516-r59usk02 1737 10 was be VBD cord-014516-r59usk02 1737 11 overall overall RB cord-014516-r59usk02 1737 12 similar similar JJ cord-014516-r59usk02 1737 13 with with IN cord-014516-r59usk02 1737 14 the the DT cord-014516-r59usk02 1737 15 two two CD cord-014516-r59usk02 1737 16 methods method NNS cord-014516-r59usk02 1737 17 : : : cord-014516-r59usk02 1737 18 8 8 CD cord-014516-r59usk02 1737 19 dogs dog NNS cord-014516-r59usk02 1737 20 had have VBD cord-014516-r59usk02 1737 21 vacuolar vacuolar NNP cord-014516-r59usk02 1737 22 hepatopathy hepatopathy NNP cord-014516-r59usk02 1737 23 , , , cord-014516-r59usk02 1737 24 4 4 CD cord-014516-r59usk02 1737 25 acute acute JJ cord-014516-r59usk02 1737 26 cholangitis cholangitis NN cord-014516-r59usk02 1737 27 , , , cord-014516-r59usk02 1737 28 non non JJ cord-014516-r59usk02 1737 29 - - JJ cord-014516-r59usk02 1737 30 specific specific JJ cord-014516-r59usk02 1737 31 acute acute JJ cord-014516-r59usk02 1737 32 form form NN cord-014516-r59usk02 1737 33 in in IN cord-014516-r59usk02 1737 34 3 3 CD cord-014516-r59usk02 1737 35 dogs dog NNS cord-014516-r59usk02 1737 36 . . . cord-014516-r59usk02 1738 1 Chronic chronic JJ cord-014516-r59usk02 1738 2 hepatitis hepatitis NN cord-014516-r59usk02 1738 3 with with IN cord-014516-r59usk02 1738 4 cirrhosis cirrhosis NN cord-014516-r59usk02 1738 5 was be VBD cord-014516-r59usk02 1738 6 found find VBN cord-014516-r59usk02 1738 7 in in IN cord-014516-r59usk02 1738 8 2 2 CD cord-014516-r59usk02 1738 9 cases case NNS cord-014516-r59usk02 1738 10 , , , cord-014516-r59usk02 1738 11 3 3 CD cord-014516-r59usk02 1738 12 dogs dog NNS cord-014516-r59usk02 1738 13 had have VBD cord-014516-r59usk02 1738 14 diffuse diffuse JJ cord-014516-r59usk02 1738 15 neoplasia neoplasia NN cord-014516-r59usk02 1738 16 and and CC cord-014516-r59usk02 1738 17 2 2 CD cord-014516-r59usk02 1738 18 miscellaneous miscellaneous JJ cord-014516-r59usk02 1738 19 hepatic hepatic JJ cord-014516-r59usk02 1738 20 disorders disorder NNS cord-014516-r59usk02 1738 21 . . . cord-014516-r59usk02 1739 1 The the DT cord-014516-r59usk02 1739 2 fibrosis fibrosis NN cord-014516-r59usk02 1739 3 was be VBD cord-014516-r59usk02 1739 4 considered consider VBN cord-014516-r59usk02 1739 5 to to TO cord-014516-r59usk02 1739 6 be be VB cord-014516-r59usk02 1739 7 severe severe JJ cord-014516-r59usk02 1739 8 in in IN cord-014516-r59usk02 1739 9 3 3 CD cord-014516-r59usk02 1739 10 dogs dog NNS cord-014516-r59usk02 1739 11 , , , cord-014516-r59usk02 1739 12 moderate moderate JJ cord-014516-r59usk02 1739 13 in in IN cord-014516-r59usk02 1739 14 3 3 CD cord-014516-r59usk02 1739 15 dogs dog NNS cord-014516-r59usk02 1739 16 and and CC cord-014516-r59usk02 1739 17 mild mild JJ cord-014516-r59usk02 1739 18 in in IN cord-014516-r59usk02 1739 19 11 11 CD cord-014516-r59usk02 1739 20 dogs dog NNS cord-014516-r59usk02 1739 21 . . . cord-014516-r59usk02 1740 1 No no DT cord-014516-r59usk02 1740 2 quantitative quantitative JJ cord-014516-r59usk02 1740 3 and and CC cord-014516-r59usk02 1740 4 qualitative qualitative JJ cord-014516-r59usk02 1740 5 difference difference NN cord-014516-r59usk02 1740 6 was be VBD cord-014516-r59usk02 1740 7 observed observe VBN cord-014516-r59usk02 1740 8 between between IN cord-014516-r59usk02 1740 9 the the DT cord-014516-r59usk02 1740 10 two two CD cord-014516-r59usk02 1740 11 types type NNS cord-014516-r59usk02 1740 12 of of IN cord-014516-r59usk02 1740 13 biopsies biopsy NNS cord-014516-r59usk02 1740 14 specimen specimen JJ cord-014516-r59usk02 1740 15 . . . cord-014516-r59usk02 1741 1 This this DT cord-014516-r59usk02 1741 2 study study NN cord-014516-r59usk02 1741 3 demonstrates demonstrate VBZ cord-014516-r59usk02 1741 4 that that IN cord-014516-r59usk02 1741 5 the the DT cord-014516-r59usk02 1741 6 biopsies biopsy NNS cord-014516-r59usk02 1741 7 with with IN cord-014516-r59usk02 1741 8 a a DT cord-014516-r59usk02 1741 9 needle needle NN cord-014516-r59usk02 1741 10 length length NN cord-014516-r59usk02 1741 11 of of IN cord-014516-r59usk02 1741 12 at at RB cord-014516-r59usk02 1741 13 least least RBS cord-014516-r59usk02 1741 14 10 10 CD cord-014516-r59usk02 1741 15 mm mm NN cord-014516-r59usk02 1741 16 brings bring VBZ cord-014516-r59usk02 1741 17 satisfactory satisfactory JJ cord-014516-r59usk02 1741 18 information information NN cord-014516-r59usk02 1741 19 for for IN cord-014516-r59usk02 1741 20 the the DT cord-014516-r59usk02 1741 21 evaluation evaluation NN cord-014516-r59usk02 1741 22 of of IN cord-014516-r59usk02 1741 23 most most JJS cord-014516-r59usk02 1741 24 of of IN cord-014516-r59usk02 1741 25 the the DT cord-014516-r59usk02 1741 26 inflammatory inflammatory JJ cord-014516-r59usk02 1741 27 , , , cord-014516-r59usk02 1741 28 vacuolar vacuolar NNP cord-014516-r59usk02 1741 29 hepatopathies hepatopathie NNS cord-014516-r59usk02 1741 30 , , , cord-014516-r59usk02 1741 31 fibrosis fibrosis NN cord-014516-r59usk02 1741 32 and and CC cord-014516-r59usk02 1741 33 diffuse diffuse VB cord-014516-r59usk02 1741 34 tumoral tumoral JJ cord-014516-r59usk02 1741 35 infiltrations infiltration NNS cord-014516-r59usk02 1741 36 . . . cord-014516-r59usk02 1742 1 Wedge wedge NN cord-014516-r59usk02 1742 2 biopsies biopsy NNS cord-014516-r59usk02 1742 3 allow allow VBP cord-014516-r59usk02 1742 4 to to TO cord-014516-r59usk02 1742 5 examine examine VB cord-014516-r59usk02 1742 6 the the DT cord-014516-r59usk02 1742 7 largest large JJS cord-014516-r59usk02 1742 8 number number NN cord-014516-r59usk02 1742 9 of of IN cord-014516-r59usk02 1742 10 portal portal NNP cord-014516-r59usk02 1742 11 triad triad NN cord-014516-r59usk02 1742 12 , , , cord-014516-r59usk02 1742 13 more more RBR cord-014516-r59usk02 1742 14 contributory contributory JJ cord-014516-r59usk02 1742 15 for for IN cord-014516-r59usk02 1742 16 certain certain JJ cord-014516-r59usk02 1742 17 forms form NNS cord-014516-r59usk02 1742 18 of of IN cord-014516-r59usk02 1742 19 cholangitis cholangitis NN cord-014516-r59usk02 1742 20 affecting affect VBG cord-014516-r59usk02 1742 21 larger large JJR cord-014516-r59usk02 1742 22 canals canal NNS cord-014516-r59usk02 1742 23 and and CC cord-014516-r59usk02 1742 24 for for IN cord-014516-r59usk02 1742 25 a a DT cord-014516-r59usk02 1742 26 single single JJ cord-014516-r59usk02 1742 27 case case NN cord-014516-r59usk02 1742 28 , , , cord-014516-r59usk02 1742 29 images image NNS cord-014516-r59usk02 1742 30 of of IN cord-014516-r59usk02 1742 31 peri peri NN cord-014516-r59usk02 1742 32 - - HYPH cord-014516-r59usk02 1742 33 hepatitis hepatitis NNP cord-014516-r59usk02 1742 34 were be VBD cord-014516-r59usk02 1742 35 counted count VBN cord-014516-r59usk02 1742 36 at at IN cord-014516-r59usk02 1742 37 the the DT cord-014516-r59usk02 1742 38 level level NN cord-014516-r59usk02 1742 39 of of IN cord-014516-r59usk02 1742 40 the the DT cord-014516-r59usk02 1742 41 capsule capsule NN cord-014516-r59usk02 1742 42 . . . cord-014516-r59usk02 1743 1 Fibrosis fibrosis NN cord-014516-r59usk02 1743 2 does do VBZ cord-014516-r59usk02 1743 3 not not RB cord-014516-r59usk02 1743 4 seem seem VB cord-014516-r59usk02 1743 5 to to TO cord-014516-r59usk02 1743 6 be be VB cord-014516-r59usk02 1743 7 more more RBR cord-014516-r59usk02 1743 8 important important JJ cord-014516-r59usk02 1743 9 in in IN cord-014516-r59usk02 1743 10 the the DT cord-014516-r59usk02 1743 11 sub sub JJ cord-014516-r59usk02 1743 12 - - JJ cord-014516-r59usk02 1743 13 capsular capsular JJ cord-014516-r59usk02 1743 14 zone zone NN cord-014516-r59usk02 1743 15 contrary contrary JJ cord-014516-r59usk02 1743 16 to to IN cord-014516-r59usk02 1743 17 what what WP cord-014516-r59usk02 1743 18 is be VBZ cord-014516-r59usk02 1743 19 observed observe VBN cord-014516-r59usk02 1743 20 in in IN cord-014516-r59usk02 1743 21 human human JJ cord-014516-r59usk02 1743 22 pathology pathology NN cord-014516-r59usk02 1743 23 . . . cord-014516-r59usk02 1744 1 No no DT cord-014516-r59usk02 1744 2 conflicts conflict NNS cord-014516-r59usk02 1744 3 of of IN cord-014516-r59usk02 1744 4 interest interest NN cord-014516-r59usk02 1744 5 reported report VBN cord-014516-r59usk02 1744 6 . . . cord-014516-r59usk02 1745 1 Indocyanine Indocyanine NNP cord-014516-r59usk02 1745 2 green green JJ cord-014516-r59usk02 1745 3 ( ( -LRB- cord-014516-r59usk02 1745 4 ICG ICG NNP cord-014516-r59usk02 1745 5 ) ) -RRB- cord-014516-r59usk02 1745 6 , , , cord-014516-r59usk02 1745 7 a a DT cord-014516-r59usk02 1745 8 fluorescence fluorescence NN cord-014516-r59usk02 1745 9 dye dye NN cord-014516-r59usk02 1745 10 , , , cord-014516-r59usk02 1745 11 is be VBZ cord-014516-r59usk02 1745 12 excreted excrete VBN cord-014516-r59usk02 1745 13 solely solely RB cord-014516-r59usk02 1745 14 by by IN cord-014516-r59usk02 1745 15 the the DT cord-014516-r59usk02 1745 16 liver liver NN cord-014516-r59usk02 1745 17 without without IN cord-014516-r59usk02 1745 18 enterohepatic enterohepatic NNP cord-014516-r59usk02 1745 19 re re NN cord-014516-r59usk02 1745 20 - - NN cord-014516-r59usk02 1745 21 circulation circulation NN cord-014516-r59usk02 1745 22 . . . cord-014516-r59usk02 1746 1 Hence hence RB cord-014516-r59usk02 1746 2 it -PRON- PRP cord-014516-r59usk02 1746 3 has have VBZ cord-014516-r59usk02 1746 4 been be VBN cord-014516-r59usk02 1746 5 used use VBN cord-014516-r59usk02 1746 6 for for IN cord-014516-r59usk02 1746 7 decades decade NNS cord-014516-r59usk02 1746 8 as as IN cord-014516-r59usk02 1746 9 an an DT cord-014516-r59usk02 1746 10 ideal ideal NN cord-014516-r59usk02 1746 11 albeit albeit IN cord-014516-r59usk02 1746 12 invasive invasive JJ cord-014516-r59usk02 1746 13 marker marker NN cord-014516-r59usk02 1746 14 of of IN cord-014516-r59usk02 1746 15 hepatic hepatic JJ cord-014516-r59usk02 1746 16 function function NN cord-014516-r59usk02 1746 17 and and CC cord-014516-r59usk02 1746 18 blood blood NN cord-014516-r59usk02 1746 19 flow flow NN cord-014516-r59usk02 1746 20 in in IN cord-014516-r59usk02 1746 21 cats cat NNS cord-014516-r59usk02 1746 22 and and CC cord-014516-r59usk02 1746 23 dogs dog NNS cord-014516-r59usk02 1746 24 . . . cord-014516-r59usk02 1747 1 Here here RB cord-014516-r59usk02 1747 2 we -PRON- PRP cord-014516-r59usk02 1747 3 evaluated evaluate VBD cord-014516-r59usk02 1747 4 the the DT cord-014516-r59usk02 1747 5 feasibility feasibility NN cord-014516-r59usk02 1747 6 of of IN cord-014516-r59usk02 1747 7 a a DT cord-014516-r59usk02 1747 8 minimally minimally RB cord-014516-r59usk02 1747 9 invasive invasive JJ cord-014516-r59usk02 1747 10 transcutaneous transcutaneous JJ cord-014516-r59usk02 1747 11 ICG icg NN cord-014516-r59usk02 1747 12 clearance clearance NN cord-014516-r59usk02 1747 13 to to TO cord-014516-r59usk02 1747 14 assess assess VB cord-014516-r59usk02 1747 15 hepatic hepatic JJ cord-014516-r59usk02 1747 16 function function NN cord-014516-r59usk02 1747 17 instantaneously instantaneously RB cord-014516-r59usk02 1747 18 . . . cord-014516-r59usk02 1748 1 Transcutaneous transcutaneous JJ cord-014516-r59usk02 1748 2 ICG ICG NNP cord-014516-r59usk02 1748 3 clearance clearance NN cord-014516-r59usk02 1748 4 was be VBD cord-014516-r59usk02 1748 5 performed perform VBN cord-014516-r59usk02 1748 6 in in IN cord-014516-r59usk02 1748 7 3 3 CD cord-014516-r59usk02 1748 8 healthy healthy JJ cord-014516-r59usk02 1748 9 research research NN cord-014516-r59usk02 1748 10 cats cat NNS cord-014516-r59usk02 1748 11 and and CC cord-014516-r59usk02 1748 12 3 3 CD cord-014516-r59usk02 1748 13 healthy healthy JJ cord-014516-r59usk02 1748 14 research research NN cord-014516-r59usk02 1748 15 dogs dog NNS cord-014516-r59usk02 1748 16 with with IN cord-014516-r59usk02 1748 17 normal normal JJ cord-014516-r59usk02 1748 18 liver liver NN cord-014516-r59usk02 1748 19 function function NN cord-014516-r59usk02 1748 20 ( ( -LRB- cord-014516-r59usk02 1748 21 bile bile NN cord-014516-r59usk02 1748 22 acid acid NN cord-014516-r59usk02 1748 23 stimulation stimulation NN cord-014516-r59usk02 1748 24 test test NN cord-014516-r59usk02 1748 25 , , , cord-014516-r59usk02 1748 26 ammonia ammonia NN cord-014516-r59usk02 1748 27 tolerance tolerance NN cord-014516-r59usk02 1748 28 test test NN cord-014516-r59usk02 1748 29 ) ) -RRB- cord-014516-r59usk02 1748 30 using use VBG cord-014516-r59usk02 1748 31 a a DT cord-014516-r59usk02 1748 32 modified modify VBN cord-014516-r59usk02 1748 33 device device NN cord-014516-r59usk02 1748 34 ( ( -LRB- cord-014516-r59usk02 1748 35 Kidney Kidney NNP cord-014516-r59usk02 1748 36 Int Int NNP cord-014516-r59usk02 1748 37 2011 2011 CD cord-014516-r59usk02 1748 38 79:1254 79:1254 CD cord-014516-r59usk02 1748 39 with with IN cord-014516-r59usk02 1748 40 an an DT cord-014516-r59usk02 1748 41 excitation excitation NN cord-014516-r59usk02 1748 42 wave wave NN cord-014516-r59usk02 1748 43 length length NN cord-014516-r59usk02 1748 44 of of IN cord-014516-r59usk02 1748 45 760 760 CD cord-014516-r59usk02 1748 46 nm nm NN cord-014516-r59usk02 1748 47 and and CC cord-014516-r59usk02 1748 48 an an DT cord-014516-r59usk02 1748 49 emission emission NN cord-014516-r59usk02 1748 50 wave wave NN cord-014516-r59usk02 1748 51 length length NN cord-014516-r59usk02 1748 52 of of IN cord-014516-r59usk02 1748 53 820 820 CD cord-014516-r59usk02 1748 54 nm nm NN cord-014516-r59usk02 1748 55 . . . cord-014516-r59usk02 1749 1 The the DT cord-014516-r59usk02 1749 2 devices device NNS cord-014516-r59usk02 1749 3 were be VBD cord-014516-r59usk02 1749 4 placed place VBN cord-014516-r59usk02 1749 5 on on IN cord-014516-r59usk02 1749 6 different different JJ cord-014516-r59usk02 1749 7 locations location NNS cord-014516-r59usk02 1749 8 ( ( -LRB- cord-014516-r59usk02 1749 9 lateral lateral JJ cord-014516-r59usk02 1749 10 thoracic thoracic JJ cord-014516-r59usk02 1749 11 wall wall NN cord-014516-r59usk02 1749 12 , , , cord-014516-r59usk02 1749 13 ventrolateral ventrolateral JJ cord-014516-r59usk02 1749 14 abdomen abdomen NN cord-014516-r59usk02 1749 15 , , , cord-014516-r59usk02 1749 16 metatarsus metatarsus NN cord-014516-r59usk02 1749 17 and and CC cord-014516-r59usk02 1749 18 antebrachium antebrachium NN cord-014516-r59usk02 1749 19 ) ) -RRB- cord-014516-r59usk02 1749 20 and and CC cord-014516-r59usk02 1749 21 fixed fix VBN cord-014516-r59usk02 1749 22 with with IN cord-014516-r59usk02 1749 23 a a DT cord-014516-r59usk02 1749 24 light light JJ cord-014516-r59usk02 1749 25 bandage bandage NN cord-014516-r59usk02 1749 26 . . . cord-014516-r59usk02 1750 1 To to TO cord-014516-r59usk02 1750 2 find find VB cord-014516-r59usk02 1750 3 a a DT cord-014516-r59usk02 1750 4 suitable suitable JJ cord-014516-r59usk02 1750 5 dose dose NN cord-014516-r59usk02 1750 6 to to TO cord-014516-r59usk02 1750 7 reach reach VB cord-014516-r59usk02 1750 8 adequate adequate JJ cord-014516-r59usk02 1750 9 transcutaneous transcutaneous JJ cord-014516-r59usk02 1750 10 peak peak NN cord-014516-r59usk02 1750 11 concentrations concentration NNS cord-014516-r59usk02 1750 12 escalating escalate VBG cord-014516-r59usk02 1750 13 doses dose NNS cord-014516-r59usk02 1750 14 of of IN cord-014516-r59usk02 1750 15 ICG ICG NNP cord-014516-r59usk02 1750 16 ( ( -LRB- cord-014516-r59usk02 1750 17 0.1 0.1 CD cord-014516-r59usk02 1750 18 , , , cord-014516-r59usk02 1750 19 0.2 0.2 CD cord-014516-r59usk02 1750 20 and and CC cord-014516-r59usk02 1750 21 0.3 0.3 CD cord-014516-r59usk02 1750 22 mg mg NNP cord-014516-r59usk02 1750 23 / / SYM cord-014516-r59usk02 1750 24 kg kg NNP cord-014516-r59usk02 1750 25 ) ) -RRB- cord-014516-r59usk02 1750 26 were be VBD cord-014516-r59usk02 1750 27 injected inject VBN cord-014516-r59usk02 1750 28 intravenously intravenously RB cord-014516-r59usk02 1750 29 with with IN cord-014516-r59usk02 1750 30 a a DT cord-014516-r59usk02 1750 31 wash wash NN cord-014516-r59usk02 1750 32 out out IN cord-014516-r59usk02 1750 33 period period NN cord-014516-r59usk02 1750 34 of of IN cord-014516-r59usk02 1750 35 at at RB cord-014516-r59usk02 1750 36 least least JJS cord-014516-r59usk02 1750 37 24 24 CD cord-014516-r59usk02 1750 38 h h NN cord-014516-r59usk02 1750 39 in in IN cord-014516-r59usk02 1750 40 - - HYPH cord-014516-r59usk02 1750 41 between between NN cord-014516-r59usk02 1750 42 . . . cord-014516-r59usk02 1751 1 Measurement measurement NN cord-014516-r59usk02 1751 2 was be VBD cord-014516-r59usk02 1751 3 continued continue VBN cord-014516-r59usk02 1751 4 for for IN cord-014516-r59usk02 1751 5 1 1 CD cord-014516-r59usk02 1751 6 hour hour NN cord-014516-r59usk02 1751 7 after after IN cord-014516-r59usk02 1751 8 injection injection NN cord-014516-r59usk02 1751 9 in in IN cord-014516-r59usk02 1751 10 awake awake JJ cord-014516-r59usk02 1751 11 animals animal NNS cord-014516-r59usk02 1751 12 moving move VBG cord-014516-r59usk02 1751 13 freely freely RB cord-014516-r59usk02 1751 14 . . . cord-014516-r59usk02 1752 1 The the DT cord-014516-r59usk02 1752 2 resulting result VBG cord-014516-r59usk02 1752 3 ICG ICG NNP cord-014516-r59usk02 1752 4 disappearance disappearance NN cord-014516-r59usk02 1752 5 curves curve NNS cord-014516-r59usk02 1752 6 were be VBD cord-014516-r59usk02 1752 7 visually visually RB cord-014516-r59usk02 1752 8 inspected inspect VBN cord-014516-r59usk02 1752 9 to to TO cord-014516-r59usk02 1752 10 find find VB cord-014516-r59usk02 1752 11 best good JJS cord-014516-r59usk02 1752 12 location location NN cord-014516-r59usk02 1752 13 ( ( -LRB- cord-014516-r59usk02 1752 14 minimal minimal JJ cord-014516-r59usk02 1752 15 artifacts artifact NNS cord-014516-r59usk02 1752 16 , , , cord-014516-r59usk02 1752 17 acceptable acceptable JJ cord-014516-r59usk02 1752 18 background background NN cord-014516-r59usk02 1752 19 noise noise NN cord-014516-r59usk02 1752 20 ) ) -RRB- cord-014516-r59usk02 1752 21 and and CC cord-014516-r59usk02 1752 22 dose dose NN cord-014516-r59usk02 1752 23 . . . cord-014516-r59usk02 1753 1 In in IN cord-014516-r59usk02 1753 2 all all DT cord-014516-r59usk02 1753 3 animals animal NNS cord-014516-r59usk02 1753 4 a a DT cord-014516-r59usk02 1753 5 dose dose NN cord-014516-r59usk02 1753 6 of of IN cord-014516-r59usk02 1753 7 0.2 0.2 CD cord-014516-r59usk02 1753 8 mg mg NNP cord-014516-r59usk02 1753 9 / / SYM cord-014516-r59usk02 1753 10 kg kg NNP cord-014516-r59usk02 1753 11 was be VBD cord-014516-r59usk02 1753 12 deemed deem VBN cord-014516-r59usk02 1753 13 ideal ideal JJ cord-014516-r59usk02 1753 14 and and CC cord-014516-r59usk02 1753 15 the the DT cord-014516-r59usk02 1753 16 thoracic thoracic JJ cord-014516-r59usk02 1753 17 and and CC cord-014516-r59usk02 1753 18 abdominal abdominal JJ cord-014516-r59usk02 1753 19 wall wall NN cord-014516-r59usk02 1753 20 gave give VBD cord-014516-r59usk02 1753 21 consistent consistent JJ cord-014516-r59usk02 1753 22 results result NNS cord-014516-r59usk02 1753 23 . . . cord-014516-r59usk02 1754 1 Half half JJ cord-014516-r59usk02 1754 2 - - HYPH cord-014516-r59usk02 1754 3 life life NN cord-014516-r59usk02 1754 4 of of IN cord-014516-r59usk02 1754 5 ICG ICG NNP cord-014516-r59usk02 1754 6 clearance clearance NN cord-014516-r59usk02 1754 7 was be VBD cord-014516-r59usk02 1754 8 calculated calculate VBN cord-014516-r59usk02 1754 9 using use VBG cord-014516-r59usk02 1754 10 a a DT cord-014516-r59usk02 1754 11 one one CD cord-014516-r59usk02 1754 12 - - HYPH cord-014516-r59usk02 1754 13 compartment compartment NN cord-014516-r59usk02 1754 14 model model NN cord-014516-r59usk02 1754 15 . . . cord-014516-r59usk02 1755 1 Half half RB cord-014516-r59usk02 1755 2 - - HYPH cord-014516-r59usk02 1755 3 lives life NNS cord-014516-r59usk02 1755 4 in in IN cord-014516-r59usk02 1755 5 cats cat NNS cord-014516-r59usk02 1755 6 were be VBD cord-014516-r59usk02 1755 7 4.99 4.99 CD cord-014516-r59usk02 1755 8 , , , cord-014516-r59usk02 1755 9 5.23 5.23 CD cord-014516-r59usk02 1755 10 and and CC cord-014516-r59usk02 1755 11 7.19 7.19 CD cord-014516-r59usk02 1755 12 minutes minute NNS cord-014516-r59usk02 1755 13 , , , cord-014516-r59usk02 1755 14 respectively respectively RB cord-014516-r59usk02 1755 15 ; ; : cord-014516-r59usk02 1755 16 in in IN cord-014516-r59usk02 1755 17 dogs dog NNS cord-014516-r59usk02 1755 18 : : : cord-014516-r59usk02 1755 19 9.66 9.66 CD cord-014516-r59usk02 1755 20 , , , cord-014516-r59usk02 1755 21 12.51 12.51 CD cord-014516-r59usk02 1755 22 and and CC cord-014516-r59usk02 1755 23 15.58 15.58 CD cord-014516-r59usk02 1755 24 minutes minute NNS cord-014516-r59usk02 1755 25 , , , cord-014516-r59usk02 1755 26 respectively respectively RB cord-014516-r59usk02 1755 27 . . . cord-014516-r59usk02 1756 1 In in IN cord-014516-r59usk02 1756 2 conclusion conclusion NN cord-014516-r59usk02 1756 3 , , , cord-014516-r59usk02 1756 4 the the DT cord-014516-r59usk02 1756 5 transcutaneous transcutaneous JJ cord-014516-r59usk02 1756 6 assessment assessment NN cord-014516-r59usk02 1756 7 of of IN cord-014516-r59usk02 1756 8 ICG ICG NNP cord-014516-r59usk02 1756 9 clearance clearance NN cord-014516-r59usk02 1756 10 is be VBZ cord-014516-r59usk02 1756 11 feasible feasible JJ cord-014516-r59usk02 1756 12 in in IN cord-014516-r59usk02 1756 13 a a DT cord-014516-r59usk02 1756 14 clinical clinical JJ cord-014516-r59usk02 1756 15 setting setting NN cord-014516-r59usk02 1756 16 . . . cord-014516-r59usk02 1757 1 Results result NNS cord-014516-r59usk02 1757 2 are be VBP cord-014516-r59usk02 1757 3 obtained obtain VBN cord-014516-r59usk02 1757 4 within within IN cord-014516-r59usk02 1757 5 one one CD cord-014516-r59usk02 1757 6 hour hour NN cord-014516-r59usk02 1757 7 and and CC cord-014516-r59usk02 1757 8 can can MD cord-014516-r59usk02 1757 9 be be VB cord-014516-r59usk02 1757 10 assessed assess VBN cord-014516-r59usk02 1757 11 instantaneously instantaneously RB cord-014516-r59usk02 1757 12 . . . cord-014516-r59usk02 1758 1 The the DT cord-014516-r59usk02 1758 2 procedures procedure NNS cord-014516-r59usk02 1758 3 are be VBP cord-014516-r59usk02 1758 4 minimally minimally RB cord-014516-r59usk02 1758 5 invasive invasive JJ cord-014516-r59usk02 1758 6 and and CC cord-014516-r59usk02 1758 7 well well RB cord-014516-r59usk02 1758 8 tolerated tolerate VBN cord-014516-r59usk02 1758 9 by by IN cord-014516-r59usk02 1758 10 the the DT cord-014516-r59usk02 1758 11 animals animal NNS cord-014516-r59usk02 1758 12 . . . cord-014516-r59usk02 1759 1 Given give VBN cord-014516-r59usk02 1759 2 that that IN cord-014516-r59usk02 1759 3 most most JJS cord-014516-r59usk02 1759 4 patients patient NNS cord-014516-r59usk02 1759 5 with with IN cord-014516-r59usk02 1759 6 a a DT cord-014516-r59usk02 1759 7 presumed presume VBN cord-014516-r59usk02 1759 8 liver liver NN cord-014516-r59usk02 1759 9 problem problem NN cord-014516-r59usk02 1759 10 undergo undergo VBP cord-014516-r59usk02 1759 11 abdominal abdominal JJ cord-014516-r59usk02 1759 12 ultrasound ultrasound NN cord-014516-r59usk02 1759 13 no no DT cord-014516-r59usk02 1759 14 further further RB cord-014516-r59usk02 1759 15 clipping clipping NN cord-014516-r59usk02 1759 16 of of IN cord-014516-r59usk02 1759 17 hair hair NN cord-014516-r59usk02 1759 18 is be VBZ cord-014516-r59usk02 1759 19 necessary necessary JJ cord-014516-r59usk02 1759 20 as as IN cord-014516-r59usk02 1759 21 the the DT cord-014516-r59usk02 1759 22 device device NN cord-014516-r59usk02 1759 23 might may MD cord-014516-r59usk02 1759 24 be be VB cord-014516-r59usk02 1759 25 placed place VBN cord-014516-r59usk02 1759 26 in in IN cord-014516-r59usk02 1759 27 this this DT cord-014516-r59usk02 1759 28 area area NN cord-014516-r59usk02 1759 29 . . . cord-014516-r59usk02 1760 1 Further further JJ cord-014516-r59usk02 1760 2 studies study NNS cord-014516-r59usk02 1760 3 are be VBP cord-014516-r59usk02 1760 4 necessary necessary JJ cord-014516-r59usk02 1760 5 to to TO cord-014516-r59usk02 1760 6 obtain obtain VB cord-014516-r59usk02 1760 7 reference reference NN cord-014516-r59usk02 1760 8 values value NNS cord-014516-r59usk02 1760 9 in in IN cord-014516-r59usk02 1760 10 healthy healthy JJ cord-014516-r59usk02 1760 11 pets pet NNS cord-014516-r59usk02 1760 12 and and CC cord-014516-r59usk02 1760 13 those those DT cord-014516-r59usk02 1760 14 with with IN cord-014516-r59usk02 1760 15 various various JJ cord-014516-r59usk02 1760 16 conditions condition NNS cord-014516-r59usk02 1760 17 leading lead VBG cord-014516-r59usk02 1760 18 to to IN cord-014516-r59usk02 1760 19 impaired impaired JJ cord-014516-r59usk02 1760 20 hepatic hepatic JJ cord-014516-r59usk02 1760 21 function function NN cord-014516-r59usk02 1760 22 . . . cord-014516-r59usk02 1761 1 No no DT cord-014516-r59usk02 1761 2 conflicts conflict NNS cord-014516-r59usk02 1761 3 of of IN cord-014516-r59usk02 1761 4 interest interest NN cord-014516-r59usk02 1761 5 reported report VBN cord-014516-r59usk02 1761 6 . . . cord-014516-r59usk02 1762 1 Gallbladder gallbladder NN cord-014516-r59usk02 1762 2 diseases disease NNS cord-014516-r59usk02 1762 3 like like IN cord-014516-r59usk02 1762 4 gallbladder gallbladder NN cord-014516-r59usk02 1762 5 mucocele mucocele NN cord-014516-r59usk02 1762 6 and and CC cord-014516-r59usk02 1762 7 cholecystitis cholecystitis NN cord-014516-r59usk02 1762 8 can can MD cord-014516-r59usk02 1762 9 reduce reduce VB cord-014516-r59usk02 1762 10 gallbladder gallbladder NN cord-014516-r59usk02 1762 11 motility motility NN cord-014516-r59usk02 1762 12 and and CC cord-014516-r59usk02 1762 13 may may MD cord-014516-r59usk02 1762 14 lead lead VB cord-014516-r59usk02 1762 15 to to IN cord-014516-r59usk02 1762 16 cholestasis cholestasis NN cord-014516-r59usk02 1762 17 . . . cord-014516-r59usk02 1763 1 Since since IN cord-014516-r59usk02 1763 2 impaired impaired JJ cord-014516-r59usk02 1763 3 gallbladder gallbladder NN cord-014516-r59usk02 1763 4 emptying emptying NN cord-014516-r59usk02 1763 5 contributes contribute VBZ cord-014516-r59usk02 1763 6 to to IN cord-014516-r59usk02 1763 7 sludge sludge NN cord-014516-r59usk02 1763 8 and and CC cord-014516-r59usk02 1763 9 gallstone gallstone NN cord-014516-r59usk02 1763 10 formation formation NN cord-014516-r59usk02 1763 11 , , , cord-014516-r59usk02 1763 12 the the DT cord-014516-r59usk02 1763 13 evaluation evaluation NN cord-014516-r59usk02 1763 14 of of IN cord-014516-r59usk02 1763 15 gallbladder gallbladder NN cord-014516-r59usk02 1763 16 motility motility NN cord-014516-r59usk02 1763 17 requires require VBZ cord-014516-r59usk02 1763 18 accurate accurate JJ cord-014516-r59usk02 1763 19 and and CC cord-014516-r59usk02 1763 20 appropriate appropriate JJ cord-014516-r59usk02 1763 21 methodology methodology NN cord-014516-r59usk02 1763 22 . . . cord-014516-r59usk02 1764 1 Three three CD cord-014516-r59usk02 1764 2 - - HYPH cord-014516-r59usk02 1764 3 dimensional dimensional JJ cord-014516-r59usk02 1764 4 ( ( -LRB- cord-014516-r59usk02 1764 5 3D 3D NNP cord-014516-r59usk02 1764 6 ) ) -RRB- cord-014516-r59usk02 1764 7 ultrasonography ultrasonography NN cord-014516-r59usk02 1764 8 has have VBZ cord-014516-r59usk02 1764 9 been be VBN cord-014516-r59usk02 1764 10 shown show VBN cord-014516-r59usk02 1764 11 to to TO cord-014516-r59usk02 1764 12 be be VB cord-014516-r59usk02 1764 13 accurate accurate JJ cord-014516-r59usk02 1764 14 and and CC cord-014516-r59usk02 1764 15 appropriate appropriate JJ cord-014516-r59usk02 1764 16 tool tool NN cord-014516-r59usk02 1764 17 for for IN cord-014516-r59usk02 1764 18 measurement measurement NN cord-014516-r59usk02 1764 19 of of IN cord-014516-r59usk02 1764 20 gallbladder gallbladder NN cord-014516-r59usk02 1764 21 volume volume NN cord-014516-r59usk02 1764 22 in in IN cord-014516-r59usk02 1764 23 humans human NNS cord-014516-r59usk02 1764 24 . . . cord-014516-r59usk02 1765 1 Therefore therefore RB cord-014516-r59usk02 1765 2 , , , cord-014516-r59usk02 1765 3 we -PRON- PRP cord-014516-r59usk02 1765 4 applied apply VBD cord-014516-r59usk02 1765 5 this this DT cord-014516-r59usk02 1765 6 novel novel JJ cord-014516-r59usk02 1765 7 technique technique NN cord-014516-r59usk02 1765 8 for for IN cord-014516-r59usk02 1765 9 the the DT cord-014516-r59usk02 1765 10 first first JJ cord-014516-r59usk02 1765 11 time time NN cord-014516-r59usk02 1765 12 to to TO cord-014516-r59usk02 1765 13 study study VB cord-014516-r59usk02 1765 14 preprandial preprandial JJ cord-014516-r59usk02 1765 15 and and CC cord-014516-r59usk02 1765 16 postprandial postprandial JJ cord-014516-r59usk02 1765 17 gallbladder gallbladder NN cord-014516-r59usk02 1765 18 volume volume NN cord-014516-r59usk02 1765 19 in in IN cord-014516-r59usk02 1765 20 10 10 CD cord-014516-r59usk02 1765 21 healthy healthy JJ cord-014516-r59usk02 1765 22 mixed mixed JJ cord-014516-r59usk02 1765 23 - - HYPH cord-014516-r59usk02 1765 24 breed breed NN cord-014516-r59usk02 1765 25 dogs dog NNS cord-014516-r59usk02 1765 26 and and CC cord-014516-r59usk02 1765 27 compared compare VBD cord-014516-r59usk02 1765 28 the the DT cord-014516-r59usk02 1765 29 results result NNS cord-014516-r59usk02 1765 30 to to IN cord-014516-r59usk02 1765 31 twodimensional twodimensional NNP cord-014516-r59usk02 1765 32 ( ( -LRB- cord-014516-r59usk02 1765 33 2D 2D NNP cord-014516-r59usk02 1765 34 ) ) -RRB- cord-014516-r59usk02 1765 35 ultrasonography ultrasonography NN cord-014516-r59usk02 1765 36 . . . cord-014516-r59usk02 1766 1 The the DT cord-014516-r59usk02 1766 2 dogs dog NNS cord-014516-r59usk02 1766 3 were be VBD cord-014516-r59usk02 1766 4 placed place VBN cord-014516-r59usk02 1766 5 in in IN cord-014516-r59usk02 1766 6 dorsal dorsal JJ cord-014516-r59usk02 1766 7 recumbency recumbency NN cord-014516-r59usk02 1766 8 to to TO cord-014516-r59usk02 1766 9 obtain obtain VB cord-014516-r59usk02 1766 10 ultrasonographic ultrasonographic JJ cord-014516-r59usk02 1766 11 measurements measurement NNS cord-014516-r59usk02 1766 12 of of IN cord-014516-r59usk02 1766 13 the the DT cord-014516-r59usk02 1766 14 gallbladder gallbladder NN cord-014516-r59usk02 1766 15 . . . cord-014516-r59usk02 1767 1 Measurements measurement NNS cord-014516-r59usk02 1767 2 by by IN cord-014516-r59usk02 1767 3 both both DT cord-014516-r59usk02 1767 4 2D 2D NNP cord-014516-r59usk02 1767 5 and and CC cord-014516-r59usk02 1767 6 3D 3D NNP cord-014516-r59usk02 1767 7 ultrasonography ultrasonography NNP cord-014516-r59usk02 1767 8 were be VBD cord-014516-r59usk02 1767 9 recorded record VBN cord-014516-r59usk02 1767 10 in in IN cord-014516-r59usk02 1767 11 preprandial preprandial JJ cord-014516-r59usk02 1767 12 state state NN cord-014516-r59usk02 1767 13 and and CC cord-014516-r59usk02 1767 14 after after IN cord-014516-r59usk02 1767 15 ingestion ingestion NN cord-014516-r59usk02 1767 16 of of IN cord-014516-r59usk02 1767 17 full full JJ cord-014516-r59usk02 1767 18 - - HYPH cord-014516-r59usk02 1767 19 fat fat JJ cord-014516-r59usk02 1767 20 milk milk NN cord-014516-r59usk02 1767 21 . . . cord-014516-r59usk02 1768 1 The the DT cord-014516-r59usk02 1768 2 preprandial preprandial JJ cord-014516-r59usk02 1768 3 and and CC cord-014516-r59usk02 1768 4 postprandial postprandial JJ cord-014516-r59usk02 1768 5 gallbladder gallbladder NN cord-014516-r59usk02 1768 6 volumes volume NNS cord-014516-r59usk02 1768 7 determined determine VBN cord-014516-r59usk02 1768 8 by by IN cord-014516-r59usk02 1768 9 3D 3d JJ cord-014516-r59usk02 1768 10 ultrasonography ultrasonography NN cord-014516-r59usk02 1768 11 were be VBD cord-014516-r59usk02 1768 12 significantly significantly RB cord-014516-r59usk02 1768 13 higher high JJR cord-014516-r59usk02 1768 14 than than IN cord-014516-r59usk02 1768 15 corresponding correspond VBG cord-014516-r59usk02 1768 16 volumes volume NNS cord-014516-r59usk02 1768 17 by by IN cord-014516-r59usk02 1768 18 2D 2d NN cord-014516-r59usk02 1768 19 ultrasonography ultrasonography NN cord-014516-r59usk02 1768 20 ( ( -LRB- cord-014516-r59usk02 1768 21 1.11 1.11 CD cord-014516-r59usk02 1768 22 AE AE NNP cord-014516-r59usk02 1768 23 0.07 0.07 CD cord-014516-r59usk02 1768 24 vs vs IN cord-014516-r59usk02 1768 25 0.77 0.77 CD cord-014516-r59usk02 1768 26 AE AE NNP cord-014516-r59usk02 1768 27 0.06 0.06 CD cord-014516-r59usk02 1768 28 and and CC cord-014516-r59usk02 1768 29 0.81 0.81 CD cord-014516-r59usk02 1768 30 vs vs IN cord-014516-r59usk02 1768 31 0.61 0.61 CD cord-014516-r59usk02 1768 32 ml ml NNS cord-014516-r59usk02 1768 33 / / SYM cord-014516-r59usk02 1768 34 kg kg NNS cord-014516-r59usk02 1768 35 , , , cord-014516-r59usk02 1768 36 respectively respectively RB cord-014516-r59usk02 1768 37 , , , cord-014516-r59usk02 1768 38 P p NN cord-014516-r59usk02 1768 39 < < XX cord-014516-r59usk02 1768 40 0.05 0.05 CD cord-014516-r59usk02 1768 41 ) ) -RRB- cord-014516-r59usk02 1768 42 . . . cord-014516-r59usk02 1769 1 In in IN cord-014516-r59usk02 1769 2 2D 2d CD cord-014516-r59usk02 1769 3 ultrasonography ultrasonography NN cord-014516-r59usk02 1769 4 , , , cord-014516-r59usk02 1769 5 most most JJS cord-014516-r59usk02 1769 6 dogs dog NNS cord-014516-r59usk02 1769 7 ( ( -LRB- cord-014516-r59usk02 1769 8 8/10 8/10 CD cord-014516-r59usk02 1769 9 [ [ -LRB- cord-014516-r59usk02 1769 10 80 80 CD cord-014516-r59usk02 1769 11 % % NN cord-014516-r59usk02 1769 12 ] ] -RRB- cord-014516-r59usk02 1769 13 ) ) -RRB- cord-014516-r59usk02 1769 14 had have VBD cord-014516-r59usk02 1769 15 a a DT cord-014516-r59usk02 1769 16 preprandial preprandial JJ cord-014516-r59usk02 1769 17 gallbladder gallbladder NN cord-014516-r59usk02 1769 18 volume volume NN cord-014516-r59usk02 1769 19 ≤ ≤ NNP cord-014516-r59usk02 1769 20 1.00 1.00 CD cord-014516-r59usk02 1769 21 ml ml NNS cord-014516-r59usk02 1769 22 / / SYM cord-014516-r59usk02 1769 23 kg kg NN cord-014516-r59usk02 1769 24 . . . cord-014516-r59usk02 1770 1 However however RB cord-014516-r59usk02 1770 2 , , , cord-014516-r59usk02 1770 3 in in IN cord-014516-r59usk02 1770 4 3D 3d JJ cord-014516-r59usk02 1770 5 ultrasonography ultrasonography NN cord-014516-r59usk02 1770 6 , , , cord-014516-r59usk02 1770 7 6/10 6/10 CD cord-014516-r59usk02 1770 8 ( ( -LRB- cord-014516-r59usk02 1770 9 60 60 CD cord-014516-r59usk02 1770 10 % % NN cord-014516-r59usk02 1770 11 ) ) -RRB- cord-014516-r59usk02 1770 12 of of IN cord-014516-r59usk02 1770 13 dogs dog NNS cord-014516-r59usk02 1770 14 had have VBD cord-014516-r59usk02 1770 15 a a DT cord-014516-r59usk02 1770 16 preprandial preprandial JJ cord-014516-r59usk02 1770 17 gallbladder gallbladder NN cord-014516-r59usk02 1770 18 volume volume NN cord-014516-r59usk02 1770 19 ≥ ≥ CD cord-014516-r59usk02 1770 20 1.00 1.00 CD cord-014516-r59usk02 1770 21 ml ml NNS cord-014516-r59usk02 1770 22 / / SYM cord-014516-r59usk02 1770 23 kg kg NN cord-014516-r59usk02 1770 24 . . . cord-014516-r59usk02 1771 1 Gallbladder gallbladder NN cord-014516-r59usk02 1771 2 contraction contraction NN cord-014516-r59usk02 1771 3 index index NN cord-014516-r59usk02 1771 4 was be VBD cord-014516-r59usk02 1771 5 higher high JJR cord-014516-r59usk02 1771 6 in in IN cord-014516-r59usk02 1771 7 3D 3d JJ cord-014516-r59usk02 1771 8 ultrasonography ultrasonography NN cord-014516-r59usk02 1771 9 than than IN cord-014516-r59usk02 1771 10 2D 2D NNP cord-014516-r59usk02 1771 11 ultrasonography ultrasonography NN cord-014516-r59usk02 1771 12 , , , cord-014516-r59usk02 1771 13 however however RB cord-014516-r59usk02 1771 14 , , , cord-014516-r59usk02 1771 15 it -PRON- PRP cord-014516-r59usk02 1771 16 did do VBD cord-014516-r59usk02 1771 17 not not RB cord-014516-r59usk02 1771 18 reach reach VB cord-014516-r59usk02 1771 19 statistical statistical JJ cord-014516-r59usk02 1771 20 significance significance NN cord-014516-r59usk02 1771 21 ( ( -LRB- cord-014516-r59usk02 1771 22 P p NN cord-014516-r59usk02 1771 23 = = SYM cord-014516-r59usk02 1771 24 0.25 0.25 CD cord-014516-r59usk02 1771 25 ) ) -RRB- cord-014516-r59usk02 1771 26 . . . cord-014516-r59usk02 1772 1 In in IN cord-014516-r59usk02 1772 2 conclusion conclusion NN cord-014516-r59usk02 1772 3 , , , cord-014516-r59usk02 1772 4 3D 3d JJ cord-014516-r59usk02 1772 5 ultrasonography ultrasonography NN cord-014516-r59usk02 1772 6 showed show VBD cord-014516-r59usk02 1772 7 larger large JJR cord-014516-r59usk02 1772 8 gallbladder gallbladder NN cord-014516-r59usk02 1772 9 volumes volume NNS cord-014516-r59usk02 1772 10 than than IN cord-014516-r59usk02 1772 11 2D 2d JJ cord-014516-r59usk02 1772 12 ultrasonography ultrasonography NN cord-014516-r59usk02 1772 13 in in IN cord-014516-r59usk02 1772 14 healthy healthy JJ cord-014516-r59usk02 1772 15 dogs dog NNS cord-014516-r59usk02 1772 16 . . . cord-014516-r59usk02 1773 1 It -PRON- PRP cord-014516-r59usk02 1773 2 seems seem VBZ cord-014516-r59usk02 1773 3 that that IN cord-014516-r59usk02 1773 4 3D 3d JJ cord-014516-r59usk02 1773 5 ultrasonography ultrasonography NN cord-014516-r59usk02 1773 6 is be VBZ cord-014516-r59usk02 1773 7 appropriate appropriate JJ cord-014516-r59usk02 1773 8 adjunct adjunct JJ cord-014516-r59usk02 1773 9 device device NN cord-014516-r59usk02 1773 10 to to IN cord-014516-r59usk02 1773 11 2D 2d NN cord-014516-r59usk02 1773 12 ultrasonography ultrasonography NN cord-014516-r59usk02 1773 13 to to TO cord-014516-r59usk02 1773 14 estimate estimate VB cord-014516-r59usk02 1773 15 gallbladder gallbladder NN cord-014516-r59usk02 1773 16 volume volume NN cord-014516-r59usk02 1773 17 when when WRB cord-014516-r59usk02 1773 18 2D 2D NNP cord-014516-r59usk02 1773 19 ultrasonography ultrasonography NN cord-014516-r59usk02 1773 20 could could MD cord-014516-r59usk02 1773 21 not not RB cord-014516-r59usk02 1773 22 detect detect VB cord-014516-r59usk02 1773 23 whole whole JJ cord-014516-r59usk02 1773 24 gallbladder gallbladder NN cord-014516-r59usk02 1773 25 volume volume NN cord-014516-r59usk02 1773 26 . . . cord-014516-r59usk02 1774 1 More More JJR cord-014516-r59usk02 1774 2 research research NN cord-014516-r59usk02 1774 3 is be VBZ cord-014516-r59usk02 1774 4 needed need VBN cord-014516-r59usk02 1774 5 to to TO cord-014516-r59usk02 1774 6 determine determine VB cord-014516-r59usk02 1774 7 clinical clinical JJ cord-014516-r59usk02 1774 8 value value NN cord-014516-r59usk02 1774 9 of of IN cord-014516-r59usk02 1774 10 3D 3d JJ cord-014516-r59usk02 1774 11 ultrasonography ultrasonography NN cord-014516-r59usk02 1774 12 in in IN cord-014516-r59usk02 1774 13 canine canine JJ cord-014516-r59usk02 1774 14 gallbladder gallbladder NN cord-014516-r59usk02 1774 15 imaging imaging NN cord-014516-r59usk02 1774 16 . . . cord-014516-r59usk02 1775 1 No no DT cord-014516-r59usk02 1775 2 conflicts conflict NNS cord-014516-r59usk02 1775 3 of of IN cord-014516-r59usk02 1775 4 interest interest NN cord-014516-r59usk02 1775 5 reported report VBN cord-014516-r59usk02 1775 6 . . . cord-014516-r59usk02 1776 1 The the DT cord-014516-r59usk02 1776 2 aim aim NN cord-014516-r59usk02 1776 3 of of IN cord-014516-r59usk02 1776 4 our -PRON- PRP$ cord-014516-r59usk02 1776 5 study study NN cord-014516-r59usk02 1776 6 was be VBD cord-014516-r59usk02 1776 7 to to TO cord-014516-r59usk02 1776 8 compare compare VB cord-014516-r59usk02 1776 9 high high JJ cord-014516-r59usk02 1776 10 - - HYPH cord-014516-r59usk02 1776 11 definition definition NN cord-014516-r59usk02 1776 12 oscillometry oscillometry NN cord-014516-r59usk02 1776 13 ( ( -LRB- cord-014516-r59usk02 1776 14 HDO HDO NNP cord-014516-r59usk02 1776 15 ) ) -RRB- cord-014516-r59usk02 1776 16 and and CC cord-014516-r59usk02 1776 17 Doppler Doppler NNP cord-014516-r59usk02 1776 18 ultrasonographic ultrasonographic JJ cord-014516-r59usk02 1776 19 measurements measurement NNS cord-014516-r59usk02 1776 20 with with IN cord-014516-r59usk02 1776 21 direct direct JJ cord-014516-r59usk02 1776 22 blood blood NN cord-014516-r59usk02 1776 23 pressure pressure NN cord-014516-r59usk02 1776 24 measurements measurement NNS cord-014516-r59usk02 1776 25 in in IN cord-014516-r59usk02 1776 26 conscious conscious JJ cord-014516-r59usk02 1776 27 dogs dog NNS cord-014516-r59usk02 1776 28 . . . cord-014516-r59usk02 1777 1 The the DT cord-014516-r59usk02 1777 2 Doppler Doppler NNP cord-014516-r59usk02 1777 3 study study NN cord-014516-r59usk02 1777 4 was be VBD cord-014516-r59usk02 1777 5 performed perform VBN cord-014516-r59usk02 1777 6 by by IN cord-014516-r59usk02 1777 7 three three CD cord-014516-r59usk02 1777 8 investigators investigator NNS cord-014516-r59usk02 1777 9 and and CC cord-014516-r59usk02 1777 10 by by IN cord-014516-r59usk02 1777 11 using use VBG cord-014516-r59usk02 1777 12 3 3 CD cord-014516-r59usk02 1777 13 different different JJ cord-014516-r59usk02 1777 14 sphygmomanometers sphygmomanometer NNS cord-014516-r59usk02 1777 15 with with IN cord-014516-r59usk02 1777 16 3 3 CD cord-014516-r59usk02 1777 17 different different JJ cord-014516-r59usk02 1777 18 sized sized JJ cord-014516-r59usk02 1777 19 cuffs cuff NNS cord-014516-r59usk02 1777 20 . . . cord-014516-r59usk02 1778 1 Devices device NNS cord-014516-r59usk02 1778 2 and and CC cord-014516-r59usk02 1778 3 measurement measurement NN cord-014516-r59usk02 1778 4 sites site NNS cord-014516-r59usk02 1778 5 were be VBD cord-014516-r59usk02 1778 6 changed change VBN cord-014516-r59usk02 1778 7 randomly randomly RB cord-014516-r59usk02 1778 8 among among IN cord-014516-r59usk02 1778 9 the the DT cord-014516-r59usk02 1778 10 investigators investigator NNS cord-014516-r59usk02 1778 11 . . . cord-014516-r59usk02 1779 1 Cuffs cuff NNS cord-014516-r59usk02 1779 2 were be VBD cord-014516-r59usk02 1779 3 wrapped wrap VBN cord-014516-r59usk02 1779 4 around around IN cord-014516-r59usk02 1779 5 the the DT cord-014516-r59usk02 1779 6 antebrachium antebrachium NN cord-014516-r59usk02 1779 7 in in IN cord-014516-r59usk02 1779 8 the the DT cord-014516-r59usk02 1779 9 forelimb forelimb NNS cord-014516-r59usk02 1779 10 or or CC cord-014516-r59usk02 1779 11 around around IN cord-014516-r59usk02 1779 12 the the DT cord-014516-r59usk02 1779 13 mid mid NN cord-014516-r59usk02 1779 14 - - NN cord-014516-r59usk02 1779 15 metatarsus metatarsus NN cord-014516-r59usk02 1779 16 in in IN cord-014516-r59usk02 1779 17 the the DT cord-014516-r59usk02 1779 18 hind hind NN cord-014516-r59usk02 1779 19 limb limb NN cord-014516-r59usk02 1779 20 . . . cord-014516-r59usk02 1780 1 In in IN cord-014516-r59usk02 1780 2 addition addition NN cord-014516-r59usk02 1780 3 to to IN cord-014516-r59usk02 1780 4 the the DT cord-014516-r59usk02 1780 5 limb limb NN cord-014516-r59usk02 1780 6 sites site NNS cord-014516-r59usk02 1780 7 , , , cord-014516-r59usk02 1780 8 cuffs cuff NNS cord-014516-r59usk02 1780 9 were be VBD cord-014516-r59usk02 1780 10 also also RB cord-014516-r59usk02 1780 11 placed place VBN cord-014516-r59usk02 1780 12 around around IN cord-014516-r59usk02 1780 13 the the DT cord-014516-r59usk02 1780 14 base base NN cord-014516-r59usk02 1780 15 of of IN cord-014516-r59usk02 1780 16 the the DT cord-014516-r59usk02 1780 17 tail tail NN cord-014516-r59usk02 1780 18 in in IN cord-014516-r59usk02 1780 19 case case NN cord-014516-r59usk02 1780 20 of of IN cord-014516-r59usk02 1780 21 the the DT cord-014516-r59usk02 1780 22 HDO HDO NNP cord-014516-r59usk02 1780 23 method method NN cord-014516-r59usk02 1780 24 . . . cord-014516-r59usk02 1781 1 Cuff cuff NN cord-014516-r59usk02 1781 2 sizes size NNS cord-014516-r59usk02 1781 3 were be VBD cord-014516-r59usk02 1781 4 45 45 CD cord-014516-r59usk02 1781 5 - - SYM cord-014516-r59usk02 1781 6 78 78 CD cord-014516-r59usk02 1781 7 % % NN cord-014516-r59usk02 1781 8 of of IN cord-014516-r59usk02 1781 9 the the DT cord-014516-r59usk02 1781 10 measured measure VBN cord-014516-r59usk02 1781 11 limb limb NN cord-014516-r59usk02 1781 12 circumferences circumference NNS cord-014516-r59usk02 1781 13 during during IN cord-014516-r59usk02 1781 14 the the DT cord-014516-r59usk02 1781 15 Doppler Doppler NNP cord-014516-r59usk02 1781 16 measurement measurement NN cord-014516-r59usk02 1781 17 . . . cord-014516-r59usk02 1782 1 For for IN cord-014516-r59usk02 1782 2 the the DT cord-014516-r59usk02 1782 3 HDO HDO NNP cord-014516-r59usk02 1782 4 method method NN cord-014516-r59usk02 1782 5 all all DT cord-014516-r59usk02 1782 6 measurements measurement NNS cord-014516-r59usk02 1782 7 were be VBD cord-014516-r59usk02 1782 8 performed perform VBN cord-014516-r59usk02 1782 9 by by IN cord-014516-r59usk02 1782 10 the the DT cord-014516-r59usk02 1782 11 same same JJ cord-014516-r59usk02 1782 12 investigator investigator NN cord-014516-r59usk02 1782 13 and and CC cord-014516-r59usk02 1782 14 the the DT cord-014516-r59usk02 1782 15 cuffs cuff NNS cord-014516-r59usk02 1782 16 provided provide VBN cord-014516-r59usk02 1782 17 by by IN cord-014516-r59usk02 1782 18 the the DT cord-014516-r59usk02 1782 19 manufacturer manufacturer NN cord-014516-r59usk02 1782 20 were be VBD cord-014516-r59usk02 1782 21 used use VBN cord-014516-r59usk02 1782 22 : : : cord-014516-r59usk02 1782 23 the the DT cord-014516-r59usk02 1782 24 smallest small JJS cord-014516-r59usk02 1782 25 cuff cuff NN cord-014516-r59usk02 1782 26 was be VBD cord-014516-r59usk02 1782 27 used use VBN cord-014516-r59usk02 1782 28 for for IN cord-014516-r59usk02 1782 29 the the DT cord-014516-r59usk02 1782 30 hind hind NN cord-014516-r59usk02 1782 31 limb limb NN cord-014516-r59usk02 1782 32 and and CC cord-014516-r59usk02 1782 33 tail tail NN cord-014516-r59usk02 1782 34 , , , cord-014516-r59usk02 1782 35 and and CC cord-014516-r59usk02 1782 36 the the DT cord-014516-r59usk02 1782 37 medium medium JJ cord-014516-r59usk02 1782 38 cuff cuff NN cord-014516-r59usk02 1782 39 was be VBD cord-014516-r59usk02 1782 40 used use VBN cord-014516-r59usk02 1782 41 for for IN cord-014516-r59usk02 1782 42 the the DT cord-014516-r59usk02 1782 43 forelimb forelimb NN cord-014516-r59usk02 1782 44 measurements measurement NNS cord-014516-r59usk02 1782 45 . . . cord-014516-r59usk02 1783 1 Dogs dog NNS cord-014516-r59usk02 1783 2 were be VBD cord-014516-r59usk02 1783 3 gently gently RB cord-014516-r59usk02 1783 4 held hold VBN cord-014516-r59usk02 1783 5 in in IN cord-014516-r59usk02 1783 6 lateral lateral JJ cord-014516-r59usk02 1783 7 recumbent recumbent JJ cord-014516-r59usk02 1783 8 position position NN cord-014516-r59usk02 1783 9 , , , cord-014516-r59usk02 1783 10 measurement measurement NN cord-014516-r59usk02 1783 11 were be VBD cord-014516-r59usk02 1783 12 performed perform VBN cord-014516-r59usk02 1783 13 on on IN cord-014516-r59usk02 1783 14 the the DT cord-014516-r59usk02 1783 15 nondependent nondependent NN cord-014516-r59usk02 1783 16 limbs limb NNS cord-014516-r59usk02 1783 17 . . . cord-014516-r59usk02 1784 1 Radio radio NN cord-014516-r59usk02 1784 2 - - HYPH cord-014516-r59usk02 1784 3 telemetry telemetry NN cord-014516-r59usk02 1784 4 transducers transducer NNS cord-014516-r59usk02 1784 5 were be VBD cord-014516-r59usk02 1784 6 implanted implant VBN cord-014516-r59usk02 1784 7 to to IN cord-014516-r59usk02 1784 8 the the DT cord-014516-r59usk02 1784 9 right right JJ cord-014516-r59usk02 1784 10 femoral femoral JJ cord-014516-r59usk02 1784 11 artery artery NN cord-014516-r59usk02 1784 12 some some DT cord-014516-r59usk02 1784 13 months month NNS cord-014516-r59usk02 1784 14 to to IN cord-014516-r59usk02 1784 15 a a DT cord-014516-r59usk02 1784 16 year year NN cord-014516-r59usk02 1784 17 preceding precede VBG cord-014516-r59usk02 1784 18 the the DT cord-014516-r59usk02 1784 19 blood blood NN cord-014516-r59usk02 1784 20 pressure pressure NN cord-014516-r59usk02 1784 21 measurements measurement NNS cord-014516-r59usk02 1784 22 for for IN cord-014516-r59usk02 1784 23 reasons reason NNS cord-014516-r59usk02 1784 24 unrelated unrelated JJ cord-014516-r59usk02 1784 25 to to IN cord-014516-r59usk02 1784 26 our -PRON- PRP$ cord-014516-r59usk02 1784 27 study study NN cord-014516-r59usk02 1784 28 . . . cord-014516-r59usk02 1785 1 Direct direct JJ cord-014516-r59usk02 1785 2 blood blood NN cord-014516-r59usk02 1785 3 pressures pressure NNS cord-014516-r59usk02 1785 4 varied vary VBD cord-014516-r59usk02 1785 5 110 110 CD cord-014516-r59usk02 1785 6 - - SYM cord-014516-r59usk02 1785 7 214 214 CD cord-014516-r59usk02 1785 8 mmHg mmHg NNS cord-014516-r59usk02 1785 9 and and CC cord-014516-r59usk02 1785 10 139 139 CD cord-014516-r59usk02 1785 11 - - SYM cord-014516-r59usk02 1785 12 192 192 CD cord-014516-r59usk02 1785 13 mmHg mmHg NNS cord-014516-r59usk02 1785 14 during during IN cord-014516-r59usk02 1785 15 the the DT cord-014516-r59usk02 1785 16 Doppler Doppler NNP cord-014516-r59usk02 1785 17 and and CC cord-014516-r59usk02 1785 18 HDO HDO NNP cord-014516-r59usk02 1785 19 measurements measurement NNS cord-014516-r59usk02 1785 20 , , , cord-014516-r59usk02 1785 21 respectively respectively RB cord-014516-r59usk02 1785 22 . . . cord-014516-r59usk02 1786 1 Two two CD cord-014516-r59usk02 1786 2 - - HYPH cord-014516-r59usk02 1786 3 hundred hundred CD cord-014516-r59usk02 1786 4 paired pair VBD cord-014516-r59usk02 1786 5 simultaneous simultaneous JJ cord-014516-r59usk02 1786 6 Doppler Doppler NNP cord-014516-r59usk02 1786 7 and and CC cord-014516-r59usk02 1786 8 direct direct JJ cord-014516-r59usk02 1786 9 measurements measurement NNS cord-014516-r59usk02 1786 10 from from IN cord-014516-r59usk02 1786 11 11 11 CD cord-014516-r59usk02 1786 12 dogs dog NNS cord-014516-r59usk02 1786 13 and and CC cord-014516-r59usk02 1786 14 100 100 CD cord-014516-r59usk02 1786 15 paired pair VBD cord-014516-r59usk02 1786 16 simultaneous simultaneous JJ cord-014516-r59usk02 1786 17 HDO HDO NNP cord-014516-r59usk02 1786 18 and and CC cord-014516-r59usk02 1786 19 direct direct JJ cord-014516-r59usk02 1786 20 telemetric telemetric JJ cord-014516-r59usk02 1786 21 measurements measurement NNS cord-014516-r59usk02 1786 22 from from IN cord-014516-r59usk02 1786 23 7 7 CD cord-014516-r59usk02 1786 24 dogs dog NNS cord-014516-r59usk02 1786 25 were be VBD cord-014516-r59usk02 1786 26 obtained obtain VBN cord-014516-r59usk02 1786 27 . . . cord-014516-r59usk02 1787 1 At at RB cord-014516-r59usk02 1787 2 least least JJS cord-014516-r59usk02 1787 3 3 3 CD cord-014516-r59usk02 1787 4 successful successful JJ cord-014516-r59usk02 1787 5 consecutive consecutive JJ cord-014516-r59usk02 1787 6 measurements measurement NNS cord-014516-r59usk02 1787 7 could could MD cord-014516-r59usk02 1787 8 be be VB cord-014516-r59usk02 1787 9 obtained obtain VBN cord-014516-r59usk02 1787 10 by by IN cord-014516-r59usk02 1787 11 the the DT cord-014516-r59usk02 1787 12 same same JJ cord-014516-r59usk02 1787 13 investigator investigator NN cord-014516-r59usk02 1787 14 at at IN cord-014516-r59usk02 1787 15 the the DT cord-014516-r59usk02 1787 16 same same JJ cord-014516-r59usk02 1787 17 site site NN cord-014516-r59usk02 1787 18 during during IN cord-014516-r59usk02 1787 19 the the DT cord-014516-r59usk02 1787 20 Doppler Doppler NNP cord-014516-r59usk02 1787 21 or or CC cord-014516-r59usk02 1787 22 HDO HDO NNP cord-014516-r59usk02 1787 23 measurement measurement NN cord-014516-r59usk02 1787 24 in in IN cord-014516-r59usk02 1787 25 53 53 CD cord-014516-r59usk02 1787 26 and and CC cord-014516-r59usk02 1787 27 22 22 CD cord-014516-r59usk02 1787 28 cases case NNS cord-014516-r59usk02 1787 29 , , , cord-014516-r59usk02 1787 30 respectively respectively RB cord-014516-r59usk02 1787 31 . . . cord-014516-r59usk02 1788 1 Thus thus RB cord-014516-r59usk02 1788 2 , , , cord-014516-r59usk02 1788 3 the the DT cord-014516-r59usk02 1788 4 mean mean NN cord-014516-r59usk02 1788 5 of of IN cord-014516-r59usk02 1788 6 these these DT cord-014516-r59usk02 1788 7 measurements measurement NNS cord-014516-r59usk02 1788 8 could could MD cord-014516-r59usk02 1788 9 be be VB cord-014516-r59usk02 1788 10 calculated calculate VBN cord-014516-r59usk02 1788 11 similarly similarly RB cord-014516-r59usk02 1788 12 to to IN cord-014516-r59usk02 1788 13 the the DT cord-014516-r59usk02 1788 14 established establish VBN cord-014516-r59usk02 1788 15 everyday everyday JJ cord-014516-r59usk02 1788 16 clinical clinical JJ cord-014516-r59usk02 1788 17 practice practice NN cord-014516-r59usk02 1788 18 . . . cord-014516-r59usk02 1789 1 Bias Bias NNP cord-014516-r59usk02 1789 2 ( ( -LRB- cord-014516-r59usk02 1789 3 mean mean JJ cord-014516-r59usk02 1789 4 difference difference NN cord-014516-r59usk02 1789 5 ) ) -RRB- cord-014516-r59usk02 1789 6 , , , cord-014516-r59usk02 1789 7 precision precision NN cord-014516-r59usk02 1789 8 ( ( -LRB- cord-014516-r59usk02 1789 9 standard standard JJ cord-014516-r59usk02 1789 10 deviation deviation NN cord-014516-r59usk02 1789 11 ) ) -RRB- cord-014516-r59usk02 1789 12 and and CC cord-014516-r59usk02 1789 13 limits limit NNS cord-014516-r59usk02 1789 14 of of IN cord-014516-r59usk02 1789 15 agreements agreement NNS cord-014516-r59usk02 1789 16 were be VBD cord-014516-r59usk02 1789 17 calculated calculate VBN cord-014516-r59usk02 1789 18 both both CC cord-014516-r59usk02 1789 19 from from IN cord-014516-r59usk02 1789 20 the the DT cord-014516-r59usk02 1789 21 individual individual NN cord-014516-r59usk02 1789 22 paired pair VBN cord-014516-r59usk02 1789 23 measurements measurement NNS cord-014516-r59usk02 1789 24 and and CC cord-014516-r59usk02 1789 25 from from IN cord-014516-r59usk02 1789 26 the the DT cord-014516-r59usk02 1789 27 means mean NNS cord-014516-r59usk02 1789 28 of of IN cord-014516-r59usk02 1789 29 the the DT cord-014516-r59usk02 1789 30 consecutive consecutive JJ cord-014516-r59usk02 1789 31 measurements measurement NNS cord-014516-r59usk02 1789 32 using use VBG cord-014516-r59usk02 1789 33 Bland Bland NNP cord-014516-r59usk02 1789 34 - - HYPH cord-014516-r59usk02 1789 35 Altman Altman NNP cord-014516-r59usk02 1789 36 spot spot NN cord-014516-r59usk02 1789 37 analysis analysis NN cord-014516-r59usk02 1789 38 . . . cord-014516-r59usk02 1790 1 Systolic systolic JJ cord-014516-r59usk02 1790 2 measurement measurement NN cord-014516-r59usk02 1790 3 performed perform VBN cord-014516-r59usk02 1790 4 on on IN cord-014516-r59usk02 1790 5 the the DT cord-014516-r59usk02 1790 6 tail tail NN cord-014516-r59usk02 1790 7 with with IN cord-014516-r59usk02 1790 8 the the DT cord-014516-r59usk02 1790 9 HDOmethod hdomethod NN cord-014516-r59usk02 1790 10 yielded yield VBD cord-014516-r59usk02 1790 11 the the DT cord-014516-r59usk02 1790 12 smallest small JJS cord-014516-r59usk02 1790 13 bias bias NN cord-014516-r59usk02 1790 14 and and CC cord-014516-r59usk02 1790 15 deviation deviation NN cord-014516-r59usk02 1790 16 and and CC cord-014516-r59usk02 1790 17 the the DT cord-014516-r59usk02 1790 18 best good JJS cord-014516-r59usk02 1790 19 limits limit NNS cord-014516-r59usk02 1790 20 of of IN cord-014516-r59usk02 1790 21 agreement agreement NN cord-014516-r59usk02 1790 22 during during IN cord-014516-r59usk02 1790 23 this this DT cord-014516-r59usk02 1790 24 study study NN cord-014516-r59usk02 1790 25 . . . cord-014516-r59usk02 1791 1 Both both CC cord-014516-r59usk02 1791 2 Doppler Doppler NNP cord-014516-r59usk02 1791 3 and and CC cord-014516-r59usk02 1791 4 HDO HDO NNP cord-014516-r59usk02 1791 5 - - HYPH cord-014516-r59usk02 1791 6 measurements measurement NNS cord-014516-r59usk02 1791 7 performed perform VBN cord-014516-r59usk02 1791 8 on on IN cord-014516-r59usk02 1791 9 the the DT cord-014516-r59usk02 1791 10 forelimb forelimb NN cord-014516-r59usk02 1791 11 overestimated overestimate VBN cord-014516-r59usk02 1791 12 , , , cord-014516-r59usk02 1791 13 while while IN cord-014516-r59usk02 1791 14 hind hind JJ cord-014516-r59usk02 1791 15 limb limb NN cord-014516-r59usk02 1791 16 measurement measurement NN cord-014516-r59usk02 1791 17 underestimated underestimate VBD cord-014516-r59usk02 1791 18 the the DT cord-014516-r59usk02 1791 19 direct direct JJ cord-014516-r59usk02 1791 20 telemetric telemetric JJ cord-014516-r59usk02 1791 21 pressures pressure NNS cord-014516-r59usk02 1791 22 . . . cord-014516-r59usk02 1792 1 Results result NNS cord-014516-r59usk02 1792 2 of of IN cord-014516-r59usk02 1792 3 all all DT cord-014516-r59usk02 1792 4 three three CD cord-014516-r59usk02 1792 5 measurement measurement NN cord-014516-r59usk02 1792 6 sites site NNS cord-014516-r59usk02 1792 7 by by IN cord-014516-r59usk02 1792 8 HDO HDO NNP cord-014516-r59usk02 1792 9 performed perform VBD cord-014516-r59usk02 1792 10 better well RBR cord-014516-r59usk02 1792 11 than than IN cord-014516-r59usk02 1792 12 forelimb forelimb NN cord-014516-r59usk02 1792 13 or or CC cord-014516-r59usk02 1792 14 hind hind NN cord-014516-r59usk02 1792 15 limb limb NN cord-014516-r59usk02 1792 16 Doppler doppler NN cord-014516-r59usk02 1792 17 - - HYPH cord-014516-r59usk02 1792 18 measurements measurement NNS cord-014516-r59usk02 1792 19 , , , cord-014516-r59usk02 1792 20 however however RB cord-014516-r59usk02 1792 21 HDO hdo NN cord-014516-r59usk02 1792 22 - - HYPH cord-014516-r59usk02 1792 23 measurements measurement NNS cord-014516-r59usk02 1792 24 were be VBD cord-014516-r59usk02 1792 25 more more RBR cord-014516-r59usk02 1792 26 difficult difficult JJ cord-014516-r59usk02 1792 27 to to TO cord-014516-r59usk02 1792 28 obtain obtain VB cord-014516-r59usk02 1792 29 and and CC cord-014516-r59usk02 1792 30 more more RBR cord-014516-r59usk02 1792 31 often often RB cord-014516-r59usk02 1792 32 resulted result VBN cord-014516-r59usk02 1792 33 with with IN cord-014516-r59usk02 1792 34 measurement measurement NN cord-014516-r59usk02 1792 35 failure failure NN cord-014516-r59usk02 1792 36 compared compare VBN cord-014516-r59usk02 1792 37 to to IN cord-014516-r59usk02 1792 38 the the DT cord-014516-r59usk02 1792 39 Doppler Doppler NNP cord-014516-r59usk02 1792 40 technique technique NN cord-014516-r59usk02 1792 41 . . . cord-014516-r59usk02 1793 1 Cuff cuff NN cord-014516-r59usk02 1793 2 size size NN cord-014516-r59usk02 1793 3 above above IN cord-014516-r59usk02 1793 4 55 55 CD cord-014516-r59usk02 1793 5 % % NN cord-014516-r59usk02 1793 6 of of IN cord-014516-r59usk02 1793 7 the the DT cord-014516-r59usk02 1793 8 measured measure VBN cord-014516-r59usk02 1793 9 limb limb NN cord-014516-r59usk02 1793 10 circumference circumference NN cord-014516-r59usk02 1793 11 showed show VBD cord-014516-r59usk02 1793 12 better well JJR cord-014516-r59usk02 1793 13 results result NNS cord-014516-r59usk02 1793 14 than than IN cord-014516-r59usk02 1793 15 smaller small JJR cord-014516-r59usk02 1793 16 cuff cuff NN cord-014516-r59usk02 1793 17 sizes size NNS cord-014516-r59usk02 1793 18 during during IN cord-014516-r59usk02 1793 19 the the DT cord-014516-r59usk02 1793 20 Doppler Doppler NNP cord-014516-r59usk02 1793 21 measurements measurement NNS cord-014516-r59usk02 1793 22 . . . cord-014516-r59usk02 1794 1 No no DT cord-014516-r59usk02 1794 2 conflicts conflict NNS cord-014516-r59usk02 1794 3 of of IN cord-014516-r59usk02 1794 4 interest interest NN cord-014516-r59usk02 1794 5 reported report VBN cord-014516-r59usk02 1794 6 . . . cord-014516-r59usk02 1795 1 The the DT cord-014516-r59usk02 1795 2 Doppler Doppler NNP cord-014516-r59usk02 1795 3 technique technique NN cord-014516-r59usk02 1795 4 is be VBZ cord-014516-r59usk02 1795 5 considered consider VBN cord-014516-r59usk02 1795 6 the the DT cord-014516-r59usk02 1795 7 most most RBS cord-014516-r59usk02 1795 8 repeatable repeatable JJ cord-014516-r59usk02 1795 9 indirect indirect JJ cord-014516-r59usk02 1795 10 method method NN cord-014516-r59usk02 1795 11 to to TO cord-014516-r59usk02 1795 12 measure measure VB cord-014516-r59usk02 1795 13 systolic systolic JJ cord-014516-r59usk02 1795 14 arterial arterial JJ cord-014516-r59usk02 1795 15 pressure pressure NN cord-014516-r59usk02 1795 16 ( ( -LRB- cord-014516-r59usk02 1795 17 SAP SAP NNP cord-014516-r59usk02 1795 18 ) ) -RRB- cord-014516-r59usk02 1795 19 in in IN cord-014516-r59usk02 1795 20 dogs dog NNS cord-014516-r59usk02 1795 21 . . . cord-014516-r59usk02 1796 1 However however RB cord-014516-r59usk02 1796 2 , , , cord-014516-r59usk02 1796 3 recent recent JJ cord-014516-r59usk02 1796 4 studies study NNS cord-014516-r59usk02 1796 5 emphasized emphasize VBD cord-014516-r59usk02 1796 6 the the DT cord-014516-r59usk02 1796 7 effect effect NN cord-014516-r59usk02 1796 8 of of IN cord-014516-r59usk02 1796 9 body body NN cord-014516-r59usk02 1796 10 position position NN cord-014516-r59usk02 1796 11 and and CC cord-014516-r59usk02 1796 12 used use VBD cord-014516-r59usk02 1796 13 limb limb NN cord-014516-r59usk02 1796 14 on on IN cord-014516-r59usk02 1796 15 SAP SAP NNP cord-014516-r59usk02 1796 16 measurement measurement NN cord-014516-r59usk02 1796 17 . . . cord-014516-r59usk02 1797 1 The the DT cord-014516-r59usk02 1797 2 aim aim NN cord-014516-r59usk02 1797 3 of of IN cord-014516-r59usk02 1797 4 this this DT cord-014516-r59usk02 1797 5 study study NN cord-014516-r59usk02 1797 6 was be VBD cord-014516-r59usk02 1797 7 to to TO cord-014516-r59usk02 1797 8 determine determine VB cord-014516-r59usk02 1797 9 whether whether IN cord-014516-r59usk02 1797 10 a a DT cord-014516-r59usk02 1797 11 difference difference NN cord-014516-r59usk02 1797 12 existed exist VBN cord-014516-r59usk02 1797 13 in in IN cord-014516-r59usk02 1797 14 SAP SAP NNP cord-014516-r59usk02 1797 15 measured measure VBN cord-014516-r59usk02 1797 16 simultaneously simultaneously RB cord-014516-r59usk02 1797 17 in in IN cord-014516-r59usk02 1797 18 dogs dog NNS cord-014516-r59usk02 1797 19 using use VBG cord-014516-r59usk02 1797 20 different different JJ cord-014516-r59usk02 1797 21 limbs limb NNS cord-014516-r59usk02 1797 22 , , , cord-014516-r59usk02 1797 23 with with IN cord-014516-r59usk02 1797 24 two two CD cord-014516-r59usk02 1797 25 Doppler Doppler NNP cord-014516-r59usk02 1797 26 units unit NNS cord-014516-r59usk02 1797 27 by by IN cord-014516-r59usk02 1797 28 two two CD cord-014516-r59usk02 1797 29 different different JJ cord-014516-r59usk02 1797 30 operators operator NNS cord-014516-r59usk02 1797 31 . . . cord-014516-r59usk02 1798 1 Sixty sixty CD cord-014516-r59usk02 1798 2 clientowned clientowne VBN cord-014516-r59usk02 1798 3 dogs dog NNS cord-014516-r59usk02 1798 4 , , , cord-014516-r59usk02 1798 5 admitted admit VBN cord-014516-r59usk02 1798 6 to to IN cord-014516-r59usk02 1798 7 the the DT cord-014516-r59usk02 1798 8 veterinary veterinary JJ cord-014516-r59usk02 1798 9 hospital hospital NN cord-014516-r59usk02 1798 10 for for IN cord-014516-r59usk02 1798 11 different different JJ cord-014516-r59usk02 1798 12 reason reason NN cord-014516-r59usk02 1798 13 , , , cord-014516-r59usk02 1798 14 were be VBD cord-014516-r59usk02 1798 15 enrolled enrol VBN cord-014516-r59usk02 1798 16 . . . cord-014516-r59usk02 1799 1 They -PRON- PRP cord-014516-r59usk02 1799 2 were be VBD cord-014516-r59usk02 1799 3 divided divide VBN cord-014516-r59usk02 1799 4 in in IN cord-014516-r59usk02 1799 5 3 3 CD cord-014516-r59usk02 1799 6 groups group NNS cord-014516-r59usk02 1799 7 based base VBN cord-014516-r59usk02 1799 8 on on IN cord-014516-r59usk02 1799 9 body body NN cord-014516-r59usk02 1799 10 size size NN cord-014516-r59usk02 1799 11 : : : cord-014516-r59usk02 1799 12 20 20 CD cord-014516-r59usk02 1799 13 small small JJ cord-014516-r59usk02 1799 14 breed breed NN cord-014516-r59usk02 1799 15 dogs dog NNS cord-014516-r59usk02 1799 16 ( ( -LRB- cord-014516-r59usk02 1799 17 < < NNP cord-014516-r59usk02 1799 18 15 15 CD cord-014516-r59usk02 1799 19 kg kg NNP cord-014516-r59usk02 1799 20 ) ) -RRB- cord-014516-r59usk02 1799 21 ; ; : cord-014516-r59usk02 1799 22 20 20 CD cord-014516-r59usk02 1799 23 medium medium NN cord-014516-r59usk02 1799 24 breed breed NN cord-014516-r59usk02 1799 25 ( ( -LRB- cord-014516-r59usk02 1799 26 15 15 CD cord-014516-r59usk02 1799 27 - - SYM cord-014516-r59usk02 1799 28 30 30 CD cord-014516-r59usk02 1799 29 kg kg NN cord-014516-r59usk02 1799 30 ) ) -RRB- cord-014516-r59usk02 1799 31 ; ; : cord-014516-r59usk02 1799 32 20 20 CD cord-014516-r59usk02 1799 33 large large JJ cord-014516-r59usk02 1799 34 breed breed NN cord-014516-r59usk02 1799 35 ( ( -LRB- cord-014516-r59usk02 1799 36 > > NFP cord-014516-r59usk02 1799 37 30 30 CD cord-014516-r59usk02 1799 38 kg kg NN cord-014516-r59usk02 1799 39 ) ) -RRB- cord-014516-r59usk02 1799 40 . . . cord-014516-r59usk02 1800 1 For for IN cord-014516-r59usk02 1800 2 each each DT cord-014516-r59usk02 1800 3 dog dog NN cord-014516-r59usk02 1800 4 the the DT cord-014516-r59usk02 1800 5 anxiety anxiety NN cord-014516-r59usk02 1800 6 status status NN cord-014516-r59usk02 1800 7 was be VBD cord-014516-r59usk02 1800 8 recorded record VBN cord-014516-r59usk02 1800 9 . . . cord-014516-r59usk02 1801 1 SAP SAP NNP cord-014516-r59usk02 1801 2 was be VBD cord-014516-r59usk02 1801 3 measured measure VBN cord-014516-r59usk02 1801 4 via via IN cord-014516-r59usk02 1801 5 Doppler doppler NN cord-014516-r59usk02 1801 6 technique technique NN cord-014516-r59usk02 1801 7 when when WRB cord-014516-r59usk02 1801 8 dogs dog NNS cord-014516-r59usk02 1801 9 were be VBD cord-014516-r59usk02 1801 10 in in IN cord-014516-r59usk02 1801 11 right right JJ cord-014516-r59usk02 1801 12 lateral lateral JJ cord-014516-r59usk02 1801 13 recumbency recumbency NN cord-014516-r59usk02 1801 14 in in IN cord-014516-r59usk02 1801 15 a a DT cord-014516-r59usk02 1801 16 quite quite JJ cord-014516-r59usk02 1801 17 environment environment NN cord-014516-r59usk02 1801 18 . . . cord-014516-r59usk02 1802 1 Right right UH cord-014516-r59usk02 1802 2 and and CC cord-014516-r59usk02 1802 3 left leave VBD cord-014516-r59usk02 1802 4 forelimb forelimb JJ cord-014516-r59usk02 1802 5 SAP SAP NNP cord-014516-r59usk02 1802 6 and and CC cord-014516-r59usk02 1802 7 left left JJ cord-014516-r59usk02 1802 8 forelimb forelimb NN cord-014516-r59usk02 1802 9 and and CC cord-014516-r59usk02 1802 10 left leave VBD cord-014516-r59usk02 1802 11 hindlimb hindlimb NN cord-014516-r59usk02 1802 12 SAP SAP NNP cord-014516-r59usk02 1802 13 were be VBD cord-014516-r59usk02 1802 14 recorded record VBN cord-014516-r59usk02 1802 15 simultaneously simultaneously RB cord-014516-r59usk02 1802 16 , , , cord-014516-r59usk02 1802 17 with with IN cord-014516-r59usk02 1802 18 two two CD cord-014516-r59usk02 1802 19 identical identical JJ cord-014516-r59usk02 1802 20 Doppler Doppler NNP cord-014516-r59usk02 1802 21 units unit NNS cord-014516-r59usk02 1802 22 equipped equip VBN cord-014516-r59usk02 1802 23 with with IN cord-014516-r59usk02 1802 24 headphones headphone NNS cord-014516-r59usk02 1802 25 , , , cord-014516-r59usk02 1802 26 by by IN cord-014516-r59usk02 1802 27 two two CD cord-014516-r59usk02 1802 28 operators operator NNS cord-014516-r59usk02 1802 29 . . . cord-014516-r59usk02 1803 1 Measurement measurement NN cord-014516-r59usk02 1803 2 was be VBD cord-014516-r59usk02 1803 3 performed perform VBN cord-014516-r59usk02 1803 4 based base VBN cord-014516-r59usk02 1803 5 on on IN cord-014516-r59usk02 1803 6 the the DT cord-014516-r59usk02 1803 7 ACVIM ACVIM NNP cord-014516-r59usk02 1803 8 guidelines guideline NNS cord-014516-r59usk02 1803 9 . . . cord-014516-r59usk02 1804 1 Five five CD cord-014516-r59usk02 1804 2 measurements measurement NNS cord-014516-r59usk02 1804 3 were be VBD cord-014516-r59usk02 1804 4 recorded record VBN cord-014516-r59usk02 1804 5 , , , cord-014516-r59usk02 1804 6 the the DT cord-014516-r59usk02 1804 7 higher high JJR cord-014516-r59usk02 1804 8 and and CC cord-014516-r59usk02 1804 9 lower low JJR cord-014516-r59usk02 1804 10 values value NNS cord-014516-r59usk02 1804 11 were be VBD cord-014516-r59usk02 1804 12 discarded discard VBN cord-014516-r59usk02 1804 13 from from IN cord-014516-r59usk02 1804 14 the the DT cord-014516-r59usk02 1804 15 analysis analysis NN cord-014516-r59usk02 1804 16 . . . cord-014516-r59usk02 1805 1 The the DT cord-014516-r59usk02 1805 2 relationship relationship NN cord-014516-r59usk02 1805 3 of of IN cord-014516-r59usk02 1805 4 mean mean JJ cord-014516-r59usk02 1805 5 SAP SAP NNP cord-014516-r59usk02 1805 6 for for IN cord-014516-r59usk02 1805 7 each each DT cord-014516-r59usk02 1805 8 limb limb NN cord-014516-r59usk02 1805 9 with with IN cord-014516-r59usk02 1805 10 body body NN cord-014516-r59usk02 1805 11 weight weight NN cord-014516-r59usk02 1805 12 , , , cord-014516-r59usk02 1805 13 sex sex NN cord-014516-r59usk02 1805 14 , , , cord-014516-r59usk02 1805 15 anxiety anxiety NN cord-014516-r59usk02 1805 16 status status NN cord-014516-r59usk02 1805 17 and and CC cord-014516-r59usk02 1805 18 SAP SAP NNP cord-014516-r59usk02 1805 19 value value NN cord-014516-r59usk02 1805 20 was be VBD cord-014516-r59usk02 1805 21 evaluated evaluate VBN cord-014516-r59usk02 1805 22 . . . cord-014516-r59usk02 1806 1 Mean mean JJ cord-014516-r59usk02 1806 2 AE AE NNP cord-014516-r59usk02 1806 3 SD SD NNP cord-014516-r59usk02 1806 4 SAP SAP NNP cord-014516-r59usk02 1806 5 was be VBD cord-014516-r59usk02 1806 6 significantly significantly RB cord-014516-r59usk02 1806 7 higher high JJR cord-014516-r59usk02 1806 8 for for IN cord-014516-r59usk02 1806 9 the the DT cord-014516-r59usk02 1806 10 right right JJ cord-014516-r59usk02 1806 11 forelimb forelimb NN cord-014516-r59usk02 1806 12 ( ( -LRB- cord-014516-r59usk02 1806 13 175.81 175.81 CD cord-014516-r59usk02 1806 14 AE AE NNP cord-014516-r59usk02 1806 15 37.15 37.15 CD cord-014516-r59usk02 1806 16 ) ) -RRB- cord-014516-r59usk02 1806 17 compare compare VBP cord-014516-r59usk02 1806 18 to to IN cord-014516-r59usk02 1806 19 the the DT cord-014516-r59usk02 1806 20 left left JJ cord-014516-r59usk02 1806 21 forelimb forelimb NN cord-014516-r59usk02 1806 22 ( ( -LRB- cord-014516-r59usk02 1806 23 165.14 165.14 CD cord-014516-r59usk02 1806 24 AE AE NNP cord-014516-r59usk02 1806 25 33.35 33.35 CD cord-014516-r59usk02 1806 26 ) ) -RRB- cord-014516-r59usk02 1806 27 on on IN cord-014516-r59usk02 1806 28 overall overall JJ cord-014516-r59usk02 1806 29 population population NN cord-014516-r59usk02 1806 30 . . . cord-014516-r59usk02 1807 1 The the DT cord-014516-r59usk02 1807 2 difference difference NN cord-014516-r59usk02 1807 3 was be VBD cord-014516-r59usk02 1807 4 significant significant JJ cord-014516-r59usk02 1807 5 for for IN cord-014516-r59usk02 1807 6 large large JJ cord-014516-r59usk02 1807 7 breed breed NN cord-014516-r59usk02 1807 8 dogs dog NNS cord-014516-r59usk02 1807 9 , , , cord-014516-r59usk02 1807 10 males male NNS cord-014516-r59usk02 1807 11 and and CC cord-014516-r59usk02 1807 12 dogs dog NNS cord-014516-r59usk02 1807 13 with with IN cord-014516-r59usk02 1807 14 SAP SAP NNP cord-014516-r59usk02 1808 1 ³ ³ CD cord-014516-r59usk02 1808 2 180 180 CD cord-014516-r59usk02 1808 3 mmHg mmHg NNS cord-014516-r59usk02 1808 4 . . . cord-014516-r59usk02 1808 5 SAP SAP NNP cord-014516-r59usk02 1808 6 was be VBD cord-014516-r59usk02 1808 7 higher high JJR cord-014516-r59usk02 1808 8 for for IN cord-014516-r59usk02 1808 9 the the DT cord-014516-r59usk02 1808 10 left left JJ cord-014516-r59usk02 1808 11 forelimb forelimb NN cord-014516-r59usk02 1808 12 ( ( -LRB- cord-014516-r59usk02 1808 13 163.67 163.67 CD cord-014516-r59usk02 1808 14 AE AE NNP cord-014516-r59usk02 1808 15 32.11 32.11 CD cord-014516-r59usk02 1808 16 ) ) -RRB- cord-014516-r59usk02 1808 17 compare compare VBP cord-014516-r59usk02 1808 18 to to IN cord-014516-r59usk02 1808 19 the the DT cord-014516-r59usk02 1808 20 left left JJ cord-014516-r59usk02 1808 21 hindlimb hindlimb NN cord-014516-r59usk02 1808 22 ( ( -LRB- cord-014516-r59usk02 1808 23 151.34 151.34 CD cord-014516-r59usk02 1808 24 AE AE NNP cord-014516-r59usk02 1808 25 34.31 34.31 CD cord-014516-r59usk02 1808 26 ) ) -RRB- cord-014516-r59usk02 1808 27 on on IN cord-014516-r59usk02 1808 28 overall overall JJ cord-014516-r59usk02 1808 29 population population NN cord-014516-r59usk02 1808 30 . . . cord-014516-r59usk02 1809 1 The the DT cord-014516-r59usk02 1809 2 difference difference NN cord-014516-r59usk02 1809 3 was be VBD cord-014516-r59usk02 1809 4 significant significant JJ cord-014516-r59usk02 1809 5 for for IN cord-014516-r59usk02 1809 6 medium medium JJ cord-014516-r59usk02 1809 7 and and CC cord-014516-r59usk02 1809 8 large large JJ cord-014516-r59usk02 1809 9 breed breed NN cord-014516-r59usk02 1809 10 dogs dog NNS cord-014516-r59usk02 1809 11 , , , cord-014516-r59usk02 1809 12 females female NNS cord-014516-r59usk02 1809 13 , , , cord-014516-r59usk02 1809 14 calm calm JJ cord-014516-r59usk02 1809 15 animals animal NNS cord-014516-r59usk02 1809 16 and and CC cord-014516-r59usk02 1809 17 dogs dog NNS cord-014516-r59usk02 1809 18 with with IN cord-014516-r59usk02 1809 19 SAP SAP NNP cord-014516-r59usk02 1809 20 ³ ³ NNP cord-014516-r59usk02 1809 21 180 180 CD cord-014516-r59usk02 1809 22 mmHg mmHg NNS cord-014516-r59usk02 1809 23 . . . cord-014516-r59usk02 1810 1 The the DT cord-014516-r59usk02 1810 2 mean mean JJ cord-014516-r59usk02 1810 3 SAP SAP NNP cord-014516-r59usk02 1810 4 from from IN cord-014516-r59usk02 1810 5 the the DT cord-014516-r59usk02 1810 6 left left JJ cord-014516-r59usk02 1810 7 forelimb forelimb NN cord-014516-r59usk02 1810 8 recorded record VBN cord-014516-r59usk02 1810 9 by by IN cord-014516-r59usk02 1810 10 two two CD cord-014516-r59usk02 1810 11 different different JJ cord-014516-r59usk02 1810 12 operators operator NNS cord-014516-r59usk02 1810 13 at at IN cord-014516-r59usk02 1810 14 two two CD cord-014516-r59usk02 1810 15 different different JJ cord-014516-r59usk02 1810 16 moments moment NNS cord-014516-r59usk02 1810 17 , , , cord-014516-r59usk02 1810 18 were be VBD cord-014516-r59usk02 1810 19 compared compare VBN cord-014516-r59usk02 1810 20 and and CC cord-014516-r59usk02 1810 21 no no DT cord-014516-r59usk02 1810 22 difference difference NN cord-014516-r59usk02 1810 23 was be VBD cord-014516-r59usk02 1810 24 evident evident JJ cord-014516-r59usk02 1810 25 . . . cord-014516-r59usk02 1811 1 In in IN cord-014516-r59usk02 1811 2 conclusion conclusion NN cord-014516-r59usk02 1811 3 , , , cord-014516-r59usk02 1811 4 SAP SAP NNP cord-014516-r59usk02 1811 5 measurement measurement NN cord-014516-r59usk02 1811 6 from from IN cord-014516-r59usk02 1811 7 different different JJ cord-014516-r59usk02 1811 8 limbs limb NNS cord-014516-r59usk02 1811 9 , , , cord-014516-r59usk02 1811 10 in in IN cord-014516-r59usk02 1811 11 dogs dog NNS cord-014516-r59usk02 1811 12 in in IN cord-014516-r59usk02 1811 13 right right JJ cord-014516-r59usk02 1811 14 lateral lateral JJ cord-014516-r59usk02 1811 15 recumbency recumbency NN cord-014516-r59usk02 1811 16 , , , cord-014516-r59usk02 1811 17 is be VBZ cord-014516-r59usk02 1811 18 poorly poorly RB cord-014516-r59usk02 1811 19 correlated correlate VBN cord-014516-r59usk02 1811 20 . . . cord-014516-r59usk02 1812 1 Measurement Measurement NNP cord-014516-r59usk02 1812 2 of of IN cord-014516-r59usk02 1812 3 SAP SAP NNP cord-014516-r59usk02 1812 4 from from IN cord-014516-r59usk02 1812 5 the the DT cord-014516-r59usk02 1812 6 left left JJ cord-014516-r59usk02 1812 7 forelimb forelimb NN cord-014516-r59usk02 1812 8 is be VBZ cord-014516-r59usk02 1812 9 more more RBR cord-014516-r59usk02 1812 10 repeatable repeatable JJ cord-014516-r59usk02 1812 11 during during IN cord-014516-r59usk02 1812 12 time time NN cord-014516-r59usk02 1812 13 and and CC cord-014516-r59usk02 1812 14 between between IN cord-014516-r59usk02 1812 15 different different JJ cord-014516-r59usk02 1812 16 operators operator NNS cord-014516-r59usk02 1812 17 . . . cord-014516-r59usk02 1813 1 SAP SAP NNP cord-014516-r59usk02 1813 2 trend trend NN cord-014516-r59usk02 1813 3 monitoring monitoring NN cord-014516-r59usk02 1813 4 should should MD cord-014516-r59usk02 1813 5 be be VB cord-014516-r59usk02 1813 6 done do VBN cord-014516-r59usk02 1813 7 using use VBG cord-014516-r59usk02 1813 8 the the DT cord-014516-r59usk02 1813 9 same same JJ cord-014516-r59usk02 1813 10 measurement measurement NN cord-014516-r59usk02 1813 11 site site NN cord-014516-r59usk02 1813 12 for for IN cord-014516-r59usk02 1813 13 any any DT cord-014516-r59usk02 1813 14 animal animal NN cord-014516-r59usk02 1813 15 . . . cord-014516-r59usk02 1814 1 No no DT cord-014516-r59usk02 1814 2 conflicts conflict NNS cord-014516-r59usk02 1814 3 of of IN cord-014516-r59usk02 1814 4 interest interest NN cord-014516-r59usk02 1814 5 reported report VBN cord-014516-r59usk02 1814 6 . . . cord-014516-r59usk02 1815 1 Amlodipine Amlodipine NNP cord-014516-r59usk02 1815 2 has have VBZ cord-014516-r59usk02 1815 3 been be VBN cord-014516-r59usk02 1815 4 considered consider VBN cord-014516-r59usk02 1815 5 the the DT cord-014516-r59usk02 1815 6 treatmenf treatmenf NNP cord-014516-r59usk02 1815 7 of of IN cord-014516-r59usk02 1815 8 choice choice NN cord-014516-r59usk02 1815 9 for for IN cord-014516-r59usk02 1815 10 hypertension hypertension NN cord-014516-r59usk02 1815 11 in in IN cord-014516-r59usk02 1815 12 cats cat NNS cord-014516-r59usk02 1815 13 for for IN cord-014516-r59usk02 1815 14 more more JJR cord-014516-r59usk02 1815 15 than than IN cord-014516-r59usk02 1815 16 a a DT cord-014516-r59usk02 1815 17 decade decade NN cord-014516-r59usk02 1815 18 . . . cord-014516-r59usk02 1816 1 There there EX cord-014516-r59usk02 1816 2 is be VBZ cord-014516-r59usk02 1816 3 , , , cord-014516-r59usk02 1816 4 however however RB cord-014516-r59usk02 1816 5 , , , cord-014516-r59usk02 1816 6 an an DT cord-014516-r59usk02 1816 7 unmet unmet JJ cord-014516-r59usk02 1816 8 need need NN cord-014516-r59usk02 1816 9 for for IN cord-014516-r59usk02 1816 10 a a DT cord-014516-r59usk02 1816 11 cat cat NN cord-014516-r59usk02 1816 12 - - HYPH cord-014516-r59usk02 1816 13 specific specific JJ cord-014516-r59usk02 1816 14 formulation formulation NN cord-014516-r59usk02 1816 15 . . . cord-014516-r59usk02 1817 1 The the DT cord-014516-r59usk02 1817 2 aim aim NN cord-014516-r59usk02 1817 3 of of IN cord-014516-r59usk02 1817 4 the the DT cord-014516-r59usk02 1817 5 study study NN cord-014516-r59usk02 1817 6 was be VBD cord-014516-r59usk02 1817 7 to to TO cord-014516-r59usk02 1817 8 assess assess VB cord-014516-r59usk02 1817 9 the the DT cord-014516-r59usk02 1817 10 efficacy efficacy NN cord-014516-r59usk02 1817 11 of of IN cord-014516-r59usk02 1817 12 chewable chewable JJ cord-014516-r59usk02 1817 13 amlodipine amlodipine NN cord-014516-r59usk02 1817 14 tablets tablet NNS cord-014516-r59usk02 1817 15 in in IN cord-014516-r59usk02 1817 16 reducing reduce VBG cord-014516-r59usk02 1817 17 systolic systolic JJ cord-014516-r59usk02 1817 18 blood blood NN cord-014516-r59usk02 1817 19 pressure pressure NN cord-014516-r59usk02 1817 20 ( ( -LRB- cord-014516-r59usk02 1817 21 SBP SBP NNP cord-014516-r59usk02 1817 22 ) ) -RRB- cord-014516-r59usk02 1817 23 in in IN cord-014516-r59usk02 1817 24 cats cat NNS cord-014516-r59usk02 1817 25 diagnosed diagnose VBN cord-014516-r59usk02 1817 26 with with IN cord-014516-r59usk02 1817 27 hypertension hypertension NN cord-014516-r59usk02 1817 28 . . . cord-014516-r59usk02 1818 1 Seventy seventy CD cord-014516-r59usk02 1818 2 - - HYPH cord-014516-r59usk02 1818 3 seven seven CD cord-014516-r59usk02 1818 4 client client NN cord-014516-r59usk02 1818 5 - - HYPH cord-014516-r59usk02 1818 6 owned own VBN cord-014516-r59usk02 1818 7 cats cat NNS cord-014516-r59usk02 1818 8 were be VBD cord-014516-r59usk02 1818 9 included include VBN cord-014516-r59usk02 1818 10 in in IN cord-014516-r59usk02 1818 11 the the DT cord-014516-r59usk02 1818 12 study study NN cord-014516-r59usk02 1818 13 ( ( -LRB- cord-014516-r59usk02 1818 14 mean mean VB cord-014516-r59usk02 1818 15 age age NN cord-014516-r59usk02 1818 16 14 14 CD cord-014516-r59usk02 1818 17 years year NNS cord-014516-r59usk02 1818 18 ) ) -RRB- cord-014516-r59usk02 1818 19 . . . cord-014516-r59usk02 1819 1 The the DT cord-014516-r59usk02 1819 2 study study NN cord-014516-r59usk02 1819 3 was be VBD cord-014516-r59usk02 1819 4 randomised randomised JJ cord-014516-r59usk02 1819 5 , , , cord-014516-r59usk02 1819 6 double double JJ cord-014516-r59usk02 1819 7 - - HYPH cord-014516-r59usk02 1819 8 blind blind JJ cord-014516-r59usk02 1819 9 , , , cord-014516-r59usk02 1819 10 placebo placebo NN cord-014516-r59usk02 1819 11 controlled control VBN cord-014516-r59usk02 1819 12 , , , cord-014516-r59usk02 1819 13 and and CC cord-014516-r59usk02 1819 14 consisted consist VBD cord-014516-r59usk02 1819 15 of of IN cord-014516-r59usk02 1819 16 two two CD cord-014516-r59usk02 1819 17 phases phase NNS cord-014516-r59usk02 1819 18 . . . cord-014516-r59usk02 1820 1 In in IN cord-014516-r59usk02 1820 2 the the DT cord-014516-r59usk02 1820 3 blinded blinded JJ cord-014516-r59usk02 1820 4 phase phase NN cord-014516-r59usk02 1820 5 , , , cord-014516-r59usk02 1820 6 42 42 CD cord-014516-r59usk02 1820 7 cats cat NNS cord-014516-r59usk02 1820 8 received receive VBD cord-014516-r59usk02 1820 9 0.125 0.125 CD cord-014516-r59usk02 1820 10 mg mg NNP cord-014516-r59usk02 1820 11 / / SYM cord-014516-r59usk02 1820 12 kg kg NNP cord-014516-r59usk02 1820 13 amlodipine amlodipine NN cord-014516-r59usk02 1820 14 once once RB cord-014516-r59usk02 1820 15 daily daily RB cord-014516-r59usk02 1820 16 for for IN cord-014516-r59usk02 1820 17 14 14 CD cord-014516-r59usk02 1820 18 days day NNS cord-014516-r59usk02 1820 19 . . . cord-014516-r59usk02 1821 1 If if IN cord-014516-r59usk02 1821 2 they -PRON- PRP cord-014516-r59usk02 1821 3 responded respond VBD cord-014516-r59usk02 1821 4 the the DT cord-014516-r59usk02 1821 5 dose dose NN cord-014516-r59usk02 1821 6 remained remain VBD cord-014516-r59usk02 1821 7 the the DT cord-014516-r59usk02 1821 8 same same JJ cord-014516-r59usk02 1821 9 to to IN cord-014516-r59usk02 1821 10 day day NN cord-014516-r59usk02 1821 11 28 28 CD cord-014516-r59usk02 1821 12 . . . cord-014516-r59usk02 1822 1 For for IN cord-014516-r59usk02 1822 2 non non JJ cord-014516-r59usk02 1822 3 - - NNS cord-014516-r59usk02 1822 4 responders responder NNS cord-014516-r59usk02 1822 5 , , , cord-014516-r59usk02 1822 6 the the DT cord-014516-r59usk02 1822 7 dose dose NN cord-014516-r59usk02 1822 8 was be VBD cord-014516-r59usk02 1822 9 increased increase VBN cord-014516-r59usk02 1822 10 to to IN cord-014516-r59usk02 1822 11 0.25 0.25 CD cord-014516-r59usk02 1822 12 mg mg NN cord-014516-r59usk02 1822 13 / / SYM cord-014516-r59usk02 1822 14 kg kg NN cord-014516-r59usk02 1822 15 . . . cord-014516-r59usk02 1823 1 Thirty thirty CD cord-014516-r59usk02 1823 2 - - HYPH cord-014516-r59usk02 1823 3 five five CD cord-014516-r59usk02 1823 4 cats cat NNS cord-014516-r59usk02 1823 5 received receive VBD cord-014516-r59usk02 1823 6 placebo placebo NN cord-014516-r59usk02 1823 7 following follow VBG cord-014516-r59usk02 1823 8 the the DT cord-014516-r59usk02 1823 9 same same JJ cord-014516-r59usk02 1823 10 protocol protocol NN cord-014516-r59usk02 1823 11 . . . cord-014516-r59usk02 1824 1 Arterial arterial JJ cord-014516-r59usk02 1824 2 blood blood NN cord-014516-r59usk02 1824 3 pressure pressure NN cord-014516-r59usk02 1824 4 was be VBD cord-014516-r59usk02 1824 5 measured measure VBN cord-014516-r59usk02 1824 6 using use VBG cord-014516-r59usk02 1824 7 a a DT cord-014516-r59usk02 1824 8 high high JJ cord-014516-r59usk02 1824 9 definition definition NN cord-014516-r59usk02 1824 10 oscillometry oscillometry NN cord-014516-r59usk02 1824 11 method method NN cord-014516-r59usk02 1824 12 . . . cord-014516-r59usk02 1825 1 At at IN cord-014516-r59usk02 1825 2 day day NN cord-014516-r59usk02 1825 3 28 28 CD cord-014516-r59usk02 1825 4 a a DT cord-014516-r59usk02 1825 5 responder responder NN cord-014516-r59usk02 1825 6 was be VBD cord-014516-r59usk02 1825 7 defined define VBN cord-014516-r59usk02 1825 8 as as IN cord-014516-r59usk02 1825 9 a a DT cord-014516-r59usk02 1825 10 cat cat NN cord-014516-r59usk02 1825 11 showing show VBG cord-014516-r59usk02 1825 12 a a DT cord-014516-r59usk02 1825 13 decrease decrease NN cord-014516-r59usk02 1825 14 of of IN cord-014516-r59usk02 1825 15 SBP SBP NNP cord-014516-r59usk02 1825 16 to to IN cord-014516-r59usk02 1825 17 ≤ ≤ $ cord-014516-r59usk02 1825 18 150 150 CD cord-014516-r59usk02 1825 19 mmHg mmHg NNS cord-014516-r59usk02 1825 20 or or CC cord-014516-r59usk02 1825 21 a a DT cord-014516-r59usk02 1825 22 decrease decrease NN cord-014516-r59usk02 1825 23 from from IN cord-014516-r59usk02 1825 24 baseline baseline NN cord-014516-r59usk02 1825 25 of of IN cord-014516-r59usk02 1825 26 at at RB cord-014516-r59usk02 1825 27 least least RBS cord-014516-r59usk02 1825 28 15 15 CD cord-014516-r59usk02 1825 29 % % NN cord-014516-r59usk02 1825 30 . . . cord-014516-r59usk02 1826 1 After after IN cord-014516-r59usk02 1826 2 28 28 CD cord-014516-r59usk02 1826 3 days day NNS cord-014516-r59usk02 1826 4 all all DT cord-014516-r59usk02 1826 5 cats cat NNS cord-014516-r59usk02 1826 6 continued continue VBD cord-014516-r59usk02 1826 7 with with IN cord-014516-r59usk02 1826 8 amlodipine amlodipine NN cord-014516-r59usk02 1826 9 for for IN cord-014516-r59usk02 1826 10 2 2 CD cord-014516-r59usk02 1826 11 - - SYM cord-014516-r59usk02 1826 12 3 3 CD cord-014516-r59usk02 1826 13 months month NNS cord-014516-r59usk02 1826 14 in in IN cord-014516-r59usk02 1826 15 an an DT cord-014516-r59usk02 1826 16 open open JJ cord-014516-r59usk02 1826 17 phase phase NN cord-014516-r59usk02 1826 18 with with IN cord-014516-r59usk02 1826 19 the the DT cord-014516-r59usk02 1826 20 placebo placebo NN cord-014516-r59usk02 1826 21 cats cat NNS cord-014516-r59usk02 1826 22 repeating repeat VBG cord-014516-r59usk02 1826 23 the the DT cord-014516-r59usk02 1826 24 same same JJ cord-014516-r59usk02 1826 25 dose dose NN cord-014516-r59usk02 1826 26 escalation escalation NN cord-014516-r59usk02 1826 27 protocol protocol NN cord-014516-r59usk02 1826 28 as as IN cord-014516-r59usk02 1826 29 in in IN cord-014516-r59usk02 1826 30 the the DT cord-014516-r59usk02 1826 31 blinded blinded JJ cord-014516-r59usk02 1826 32 phase phase NN cord-014516-r59usk02 1826 33 . . . cord-014516-r59usk02 1827 1 The the DT cord-014516-r59usk02 1827 2 responder responder NN cord-014516-r59usk02 1827 3 rate rate NN cord-014516-r59usk02 1827 4 was be VBD cord-014516-r59usk02 1827 5 63 63 CD cord-014516-r59usk02 1827 6 % % NN cord-014516-r59usk02 1827 7 in in IN cord-014516-r59usk02 1827 8 the the DT cord-014516-r59usk02 1827 9 amlodipine amlodipine NN cord-014516-r59usk02 1827 10 group group NN cord-014516-r59usk02 1827 11 and and CC cord-014516-r59usk02 1827 12 18 18 CD cord-014516-r59usk02 1827 13 % % NN cord-014516-r59usk02 1827 14 in in IN cord-014516-r59usk02 1827 15 the the DT cord-014516-r59usk02 1827 16 placebo placebo NN cord-014516-r59usk02 1827 17 group group NN cord-014516-r59usk02 1827 18 following follow VBG cord-014516-r59usk02 1827 19 the the DT cord-014516-r59usk02 1827 20 dose dose JJ cord-014516-r59usk02 1827 21 escalation escalation NN cord-014516-r59usk02 1827 22 from from IN cord-014516-r59usk02 1827 23 day day NN cord-014516-r59usk02 1827 24 14 14 CD cord-014516-r59usk02 1827 25 being be VBG cord-014516-r59usk02 1827 26 applied apply VBN cord-014516-r59usk02 1827 27 to to IN cord-014516-r59usk02 1827 28 54 54 CD cord-014516-r59usk02 1827 29 % % NN cord-014516-r59usk02 1827 30 and and CC cord-014516-r59usk02 1827 31 80 80 CD cord-014516-r59usk02 1827 32 % % NN cord-014516-r59usk02 1827 33 of of IN cord-014516-r59usk02 1827 34 cats cat NNS cord-014516-r59usk02 1827 35 receiving receive VBG cord-014516-r59usk02 1827 36 amlodipine amlodipine NN cord-014516-r59usk02 1827 37 and and CC cord-014516-r59usk02 1827 38 placebo placebo NN cord-014516-r59usk02 1827 39 respectively respectively RB cord-014516-r59usk02 1827 40 . . . cord-014516-r59usk02 1828 1 Cats cat NNS cord-014516-r59usk02 1828 2 receiving receive VBG cord-014516-r59usk02 1828 3 amlodipine amlodipine NN cord-014516-r59usk02 1828 4 were be VBD cord-014516-r59usk02 1828 5 7.9 7.9 CD cord-014516-r59usk02 1828 6 ( ( -LRB- cord-014516-r59usk02 1828 7 95 95 CD cord-014516-r59usk02 1828 8 % % NN cord-014516-r59usk02 1828 9 CI CI NNP cord-014516-r59usk02 1828 10 2.6 2.6 CD cord-014516-r59usk02 1828 11 to to IN cord-014516-r59usk02 1828 12 24.1 24.1 CD cord-014516-r59usk02 1828 13 ) ) -RRB- cord-014516-r59usk02 1828 14 times time NNS cord-014516-r59usk02 1828 15 more more RBR cord-014516-r59usk02 1828 16 likely likely JJ cord-014516-r59usk02 1828 17 to to TO cord-014516-r59usk02 1828 18 be be VB cord-014516-r59usk02 1828 19 classified classify VBN cord-014516-r59usk02 1828 20 as as IN cord-014516-r59usk02 1828 21 responders responder NNS cord-014516-r59usk02 1828 22 when when WRB cord-014516-r59usk02 1828 23 compared compare VBN cord-014516-r59usk02 1828 24 to to IN cord-014516-r59usk02 1828 25 those those DT cord-014516-r59usk02 1828 26 receiving receive VBG cord-014516-r59usk02 1828 27 placebo placebo NN cord-014516-r59usk02 1828 28 ( ( -LRB- cord-014516-r59usk02 1828 29 logistic logistic JJ cord-014516-r59usk02 1828 30 regression regression NN cord-014516-r59usk02 1828 31 model model NN cord-014516-r59usk02 1828 32 , , , cord-014516-r59usk02 1828 33 p p NN cord-014516-r59usk02 1828 34 = = SYM cord-014516-r59usk02 1828 35 0.0003 0.0003 CD cord-014516-r59usk02 1828 36 ) ) -RRB- cord-014516-r59usk02 1828 37 . . . cord-014516-r59usk02 1829 1 From from IN cord-014516-r59usk02 1829 2 a a DT cord-014516-r59usk02 1829 3 baseline baseline JJ cord-014516-r59usk02 1829 4 value value NN cord-014516-r59usk02 1829 5 of of IN cord-014516-r59usk02 1829 6 181.6 181.6 CD cord-014516-r59usk02 1829 7 AE AE NNP cord-014516-r59usk02 1829 8 12.5 12.5 CD cord-014516-r59usk02 1829 9 and and CC cord-014516-r59usk02 1829 10 179.3 179.3 CD cord-014516-r59usk02 1829 11 AE AE NNP cord-014516-r59usk02 1829 12 10.8 10.8 CD cord-014516-r59usk02 1829 13 mmHg mmHg NNS cord-014516-r59usk02 1830 1 the the DT cord-014516-r59usk02 1830 2 mean mean JJ cord-014516-r59usk02 1830 3 SBP SBP NNP cord-014516-r59usk02 1830 4 decreased decrease VBD cord-014516-r59usk02 1830 5 to to IN cord-014516-r59usk02 1830 6 153.6 153.6 CD cord-014516-r59usk02 1830 7 AE AE NNP cord-014516-r59usk02 1830 8 16.9 16.9 CD cord-014516-r59usk02 1830 9 mmHg mmHg NNS cord-014516-r59usk02 1830 10 with with IN cord-014516-r59usk02 1830 11 amlodipine amlodipine NN cord-014516-r59usk02 1830 12 and and CC cord-014516-r59usk02 1830 13 to to IN cord-014516-r59usk02 1830 14 167.7 167.7 CD cord-014516-r59usk02 1830 15 AE AE NNP cord-014516-r59usk02 1830 16 20.5 20.5 CD cord-014516-r59usk02 1830 17 mmHg mmHg NNS cord-014516-r59usk02 1830 18 with with IN cord-014516-r59usk02 1830 19 placebo placebo NN cord-014516-r59usk02 1830 20 ( ( -LRB- cord-014516-r59usk02 1830 21 repeated repeat VBN cord-014516-r59usk02 1830 22 measures measure NNS cord-014516-r59usk02 1830 23 analysis analysis NN cord-014516-r59usk02 1830 24 of of IN cord-014516-r59usk02 1830 25 covariance covariance NN cord-014516-r59usk02 1830 26 model model NN cord-014516-r59usk02 1830 27 , , , cord-014516-r59usk02 1830 28 p p NN cord-014516-r59usk02 1830 29 < < XX cord-014516-r59usk02 1830 30 0.001 0.001 CD cord-014516-r59usk02 1830 31 ) ) -RRB- cord-014516-r59usk02 1830 32 by by IN cord-014516-r59usk02 1830 33 day day NN cord-014516-r59usk02 1830 34 28 28 CD cord-014516-r59usk02 1830 35 . . . cord-014516-r59usk02 1831 1 The the DT cord-014516-r59usk02 1831 2 responder responder NN cord-014516-r59usk02 1831 3 rate rate NN cord-014516-r59usk02 1831 4 was be VBD cord-014516-r59usk02 1831 5 not not RB cord-014516-r59usk02 1831 6 influenced influence VBN cord-014516-r59usk02 1831 7 by by IN cord-014516-r59usk02 1831 8 factors factor NNS cord-014516-r59usk02 1831 9 other other JJ cord-014516-r59usk02 1831 10 than than IN cord-014516-r59usk02 1831 11 amlodipine amlodipine NN cord-014516-r59usk02 1831 12 treatment treatment NN cord-014516-r59usk02 1831 13 ( ( -LRB- cord-014516-r59usk02 1832 1 e.g. e.g. IN cord-014516-r59usk02 1832 2 baseline baseline JJ cord-014516-r59usk02 1832 3 blood blood NN cord-014516-r59usk02 1832 4 pressure pressure NN cord-014516-r59usk02 1832 5 , , , cord-014516-r59usk02 1832 6 concomitant concomitant JJ cord-014516-r59usk02 1832 7 ACE ace NN cord-014516-r59usk02 1832 8 inhibitor inhibitor NN cord-014516-r59usk02 1832 9 therapy therapy NN cord-014516-r59usk02 1832 10 , , , cord-014516-r59usk02 1832 11 renal renal JJ cord-014516-r59usk02 1832 12 disease disease NN cord-014516-r59usk02 1832 13 ) ) -RRB- cord-014516-r59usk02 1832 14 . . . cord-014516-r59usk02 1833 1 There there EX cord-014516-r59usk02 1833 2 were be VBD cord-014516-r59usk02 1833 3 no no DT cord-014516-r59usk02 1833 4 differences difference NNS cord-014516-r59usk02 1833 5 between between IN cord-014516-r59usk02 1833 6 the the DT cord-014516-r59usk02 1833 7 amlodipine amlodipine NN cord-014516-r59usk02 1833 8 and and CC cord-014516-r59usk02 1833 9 placebo placebo NN cord-014516-r59usk02 1833 10 groups group NNS cord-014516-r59usk02 1833 11 in in IN cord-014516-r59usk02 1833 12 the the DT cord-014516-r59usk02 1833 13 frequency frequency NN cord-014516-r59usk02 1833 14 of of IN cord-014516-r59usk02 1833 15 adverse adverse JJ cord-014516-r59usk02 1833 16 events event NNS cord-014516-r59usk02 1833 17 reported report VBN cord-014516-r59usk02 1833 18 during during IN cord-014516-r59usk02 1833 19 the the DT cord-014516-r59usk02 1833 20 28-day 28-day CD cord-014516-r59usk02 1833 21 blinded blinded JJ cord-014516-r59usk02 1833 22 phase phase NN cord-014516-r59usk02 1833 23 . . . cord-014516-r59usk02 1834 1 Likewise likewise RB cord-014516-r59usk02 1834 2 , , , cord-014516-r59usk02 1834 3 there there EX cord-014516-r59usk02 1834 4 were be VBD cord-014516-r59usk02 1834 5 very very RB cord-014516-r59usk02 1834 6 few few JJ cord-014516-r59usk02 1834 7 changes change NNS cord-014516-r59usk02 1834 8 in in IN cord-014516-r59usk02 1834 9 the the DT cord-014516-r59usk02 1834 10 laboratory laboratory NN cord-014516-r59usk02 1834 11 values value NNS cord-014516-r59usk02 1834 12 over over IN cord-014516-r59usk02 1834 13 time time NN cord-014516-r59usk02 1834 14 in in IN cord-014516-r59usk02 1834 15 either either DT cord-014516-r59usk02 1834 16 group group NN cord-014516-r59usk02 1834 17 . . . cord-014516-r59usk02 1835 1 The the DT cord-014516-r59usk02 1835 2 present present JJ cord-014516-r59usk02 1835 3 study study NN cord-014516-r59usk02 1835 4 is be VBZ cord-014516-r59usk02 1835 5 the the DT cord-014516-r59usk02 1835 6 first first JJ cord-014516-r59usk02 1835 7 large large JJ cord-014516-r59usk02 1835 8 clinical clinical JJ cord-014516-r59usk02 1835 9 trial trial NN cord-014516-r59usk02 1835 10 to to TO cord-014516-r59usk02 1835 11 show show VB cord-014516-r59usk02 1835 12 that that IN cord-014516-r59usk02 1835 13 amlodipine amlodipine NN cord-014516-r59usk02 1835 14 is be VBZ cord-014516-r59usk02 1835 15 clearly clearly RB cord-014516-r59usk02 1835 16 superior superior JJ cord-014516-r59usk02 1835 17 to to IN cord-014516-r59usk02 1835 18 placebo placebo NN cord-014516-r59usk02 1835 19 in in IN cord-014516-r59usk02 1835 20 the the DT cord-014516-r59usk02 1835 21 treatment treatment NN cord-014516-r59usk02 1835 22 of of IN cord-014516-r59usk02 1835 23 cats cat NNS cord-014516-r59usk02 1835 24 with with IN cord-014516-r59usk02 1835 25 hypertension hypertension NN cord-014516-r59usk02 1835 26 . . . cord-014516-r59usk02 1836 1 The the DT cord-014516-r59usk02 1836 2 chewable chewable JJ cord-014516-r59usk02 1836 3 amlodipine amlodipine NN cord-014516-r59usk02 1836 4 formulation formulation NN cord-014516-r59usk02 1836 5 effectively effectively RB cord-014516-r59usk02 1836 6 reduced reduce VBD cord-014516-r59usk02 1836 7 SBP SBP NNP cord-014516-r59usk02 1836 8 , , , cord-014516-r59usk02 1836 9 had have VBD cord-014516-r59usk02 1836 10 a a DT cord-014516-r59usk02 1836 11 good good JJ cord-014516-r59usk02 1836 12 palatability palatability NN cord-014516-r59usk02 1836 13 and and CC cord-014516-r59usk02 1836 14 was be VBD cord-014516-r59usk02 1836 15 well well RB cord-014516-r59usk02 1836 16 tolerated tolerate VBN cord-014516-r59usk02 1836 17 . . . cord-014516-r59usk02 1837 1 It -PRON- PRP cord-014516-r59usk02 1837 2 can can MD cord-014516-r59usk02 1837 3 be be VB cord-014516-r59usk02 1837 4 used use VBN cord-014516-r59usk02 1837 5 concomitantly concomitantly RB cord-014516-r59usk02 1837 6 with with IN cord-014516-r59usk02 1837 7 ACE ace NN cord-014516-r59usk02 1837 8 inhibitors inhibitor NNS cord-014516-r59usk02 1837 9 and and CC cord-014516-r59usk02 1837 10 in in IN cord-014516-r59usk02 1837 11 cats cat NNS cord-014516-r59usk02 1837 12 with with IN cord-014516-r59usk02 1837 13 renal renal JJ cord-014516-r59usk02 1837 14 disease disease NN cord-014516-r59usk02 1837 15 . . . cord-014516-r59usk02 1838 1 Conflicts conflict NNS cord-014516-r59usk02 1838 2 of of IN cord-014516-r59usk02 1838 3 interest interest NN cord-014516-r59usk02 1838 4 : : : cord-014516-r59usk02 1838 5 M. M. NNP cord-014516-r59usk02 1838 6 Huhtinen Huhtinen NNP cord-014516-r59usk02 1838 7 and and CC cord-014516-r59usk02 1838 8 J. J. NNP cord-014516-r59usk02 1838 9 Aspegr Aspegr NNP cord-014516-r59usk02 1839 1 en en NNP cord-014516-r59usk02 1839 2 are be VBP cord-014516-r59usk02 1839 3 employees employee NNS cord-014516-r59usk02 1839 4 of of IN cord-014516-r59usk02 1839 5 the the DT cord-014516-r59usk02 1839 6 sponsor sponsor NN cord-014516-r59usk02 1839 7 J. J. NNP cord-014516-r59usk02 1839 8 Elliott Elliott NNP cord-014516-r59usk02 1839 9 has have VBZ cord-014516-r59usk02 1839 10 the the DT cord-014516-r59usk02 1839 11 following follow VBG cord-014516-r59usk02 1839 12 information information NN cord-014516-r59usk02 1839 13 to to TO cord-014516-r59usk02 1839 14 disclose disclose VB cord-014516-r59usk02 1839 15 : : : cord-014516-r59usk02 1839 16 Amlodipine Amlodipine NNP cord-014516-r59usk02 1839 17 is be VBZ cord-014516-r59usk02 1839 18 the the DT cord-014516-r59usk02 1839 19 treatment treatment NN cord-014516-r59usk02 1839 20 of of IN cord-014516-r59usk02 1839 21 choice choice NN cord-014516-r59usk02 1839 22 for for IN cord-014516-r59usk02 1839 23 feline feline JJ cord-014516-r59usk02 1839 24 hypertension hypertension NN cord-014516-r59usk02 1839 25 . . . cord-014516-r59usk02 1840 1 Limited limited JJ cord-014516-r59usk02 1840 2 published publish VBN cord-014516-r59usk02 1840 3 data datum NNS cord-014516-r59usk02 1840 4 exist exist VBP cord-014516-r59usk02 1840 5 on on IN cord-014516-r59usk02 1840 6 serum serum NN cord-014516-r59usk02 1840 7 concentrations concentration NNS cord-014516-r59usk02 1840 8 achieved achieve VBN cord-014516-r59usk02 1840 9 in in IN cord-014516-r59usk02 1840 10 hypertensive hypertensive JJ cord-014516-r59usk02 1840 11 cats cat NNS cord-014516-r59usk02 1840 12 . . . cord-014516-r59usk02 1841 1 The the DT cord-014516-r59usk02 1841 2 aim aim NN cord-014516-r59usk02 1841 3 of of IN cord-014516-r59usk02 1841 4 the the DT cord-014516-r59usk02 1841 5 study study NN cord-014516-r59usk02 1841 6 was be VBD cord-014516-r59usk02 1841 7 to to TO cord-014516-r59usk02 1841 8 assess assess VB cord-014516-r59usk02 1841 9 serum serum NN cord-014516-r59usk02 1841 10 amlodipine amlodipine NN cord-014516-r59usk02 1841 11 concentrations concentration NNS cord-014516-r59usk02 1841 12 in in IN cord-014516-r59usk02 1841 13 cats cat NNS cord-014516-r59usk02 1841 14 treated treat VBN cord-014516-r59usk02 1841 15 with with IN cord-014516-r59usk02 1841 16 a a DT cord-014516-r59usk02 1841 17 new new JJ cord-014516-r59usk02 1841 18 formulation formulation NN cord-014516-r59usk02 1841 19 of of IN cord-014516-r59usk02 1841 20 amlodipine amlodipine NN cord-014516-r59usk02 1841 21 and and CC cord-014516-r59usk02 1841 22 relate relate VBP cord-014516-r59usk02 1841 23 these these DT cord-014516-r59usk02 1841 24 to to IN cord-014516-r59usk02 1841 25 the the DT cord-014516-r59usk02 1841 26 blood blood NN cord-014516-r59usk02 1841 27 pressure pressure NN cord-014516-r59usk02 1841 28 reduction reduction NN cord-014516-r59usk02 1841 29 achieved achieve VBN cord-014516-r59usk02 1841 30 . . . cord-014516-r59usk02 1842 1 Seventy seventy CD cord-014516-r59usk02 1842 2 - - HYPH cord-014516-r59usk02 1842 3 seven seven CD cord-014516-r59usk02 1842 4 client client NN cord-014516-r59usk02 1842 5 - - HYPH cord-014516-r59usk02 1842 6 owned own VBN cord-014516-r59usk02 1842 7 hypertensive hypertensive JJ cord-014516-r59usk02 1842 8 cats cat NNS cord-014516-r59usk02 1842 9 were be VBD cord-014516-r59usk02 1842 10 enrolled enrol VBN cord-014516-r59usk02 1842 11 into into IN cord-014516-r59usk02 1842 12 a a DT cord-014516-r59usk02 1842 13 randomized randomized JJ cord-014516-r59usk02 1842 14 , , , cord-014516-r59usk02 1842 15 double double JJ cord-014516-r59usk02 1842 16 - - HYPH cord-014516-r59usk02 1842 17 blind blind JJ cord-014516-r59usk02 1842 18 and and CC cord-014516-r59usk02 1842 19 placebo placebo NN cord-014516-r59usk02 1842 20 controlled control VBN cord-014516-r59usk02 1842 21 study study NN cord-014516-r59usk02 1842 22 consisting consist VBG cord-014516-r59usk02 1842 23 of of IN cord-014516-r59usk02 1842 24 two two CD cord-014516-r59usk02 1842 25 phases phase NNS cord-014516-r59usk02 1842 26 . . . cord-014516-r59usk02 1843 1 In in IN cord-014516-r59usk02 1843 2 phase phase NN cord-014516-r59usk02 1843 3 one one CD cord-014516-r59usk02 1843 4 , , , cord-014516-r59usk02 1843 5 42 42 CD cord-014516-r59usk02 1843 6 cats cat NNS cord-014516-r59usk02 1843 7 ( ( -LRB- cord-014516-r59usk02 1843 8 Group Group NNP cord-014516-r59usk02 1843 9 A A NNP cord-014516-r59usk02 1843 10 ) ) -RRB- cord-014516-r59usk02 1843 11 received receive VBD cord-014516-r59usk02 1843 12 0.125 0.125 CD cord-014516-r59usk02 1843 13 mg mg NNP cord-014516-r59usk02 1843 14 / / SYM cord-014516-r59usk02 1843 15 kg kg NNP cord-014516-r59usk02 1843 16 amlodipine amlodipine NN cord-014516-r59usk02 1843 17 once once RB cord-014516-r59usk02 1843 18 daily daily RB cord-014516-r59usk02 1843 19 for for IN cord-014516-r59usk02 1843 20 14 14 CD cord-014516-r59usk02 1843 21 days day NNS cord-014516-r59usk02 1843 22 . . . cord-014516-r59usk02 1844 1 If if IN cord-014516-r59usk02 1844 2 they -PRON- PRP cord-014516-r59usk02 1844 3 were be VBD cord-014516-r59usk02 1844 4 deemed deem VBN cord-014516-r59usk02 1844 5 to to TO cord-014516-r59usk02 1844 6 have have VB cord-014516-r59usk02 1844 7 responded respond VBN cord-014516-r59usk02 1844 8 ( ( -LRB- cord-014516-r59usk02 1844 9 see see VB cord-014516-r59usk02 1844 10 below below RB cord-014516-r59usk02 1844 11 ) ) -RRB- cord-014516-r59usk02 1845 1 the the DT cord-014516-r59usk02 1845 2 dose dose NN cord-014516-r59usk02 1845 3 remained remain VBD cord-014516-r59usk02 1845 4 the the DT cord-014516-r59usk02 1845 5 same same JJ cord-014516-r59usk02 1845 6 to to IN cord-014516-r59usk02 1845 7 day day NN cord-014516-r59usk02 1845 8 28 28 CD cord-014516-r59usk02 1845 9 . . . cord-014516-r59usk02 1846 1 For for IN cord-014516-r59usk02 1846 2 non non JJ cord-014516-r59usk02 1846 3 - - NNS cord-014516-r59usk02 1846 4 responders responder NNS cord-014516-r59usk02 1846 5 , , , cord-014516-r59usk02 1846 6 the the DT cord-014516-r59usk02 1846 7 dose dose NN cord-014516-r59usk02 1846 8 was be VBD cord-014516-r59usk02 1846 9 increased increase VBN cord-014516-r59usk02 1846 10 to to IN cord-014516-r59usk02 1846 11 0.25 0.25 CD cord-014516-r59usk02 1846 12 mg mg NN cord-014516-r59usk02 1846 13 / / SYM cord-014516-r59usk02 1846 14 kg kg NN cord-014516-r59usk02 1846 15 . . . cord-014516-r59usk02 1847 1 Thirty thirty CD cord-014516-r59usk02 1847 2 - - HYPH cord-014516-r59usk02 1847 3 five five CD cord-014516-r59usk02 1847 4 cats cat NNS cord-014516-r59usk02 1847 5 ( ( -LRB- cord-014516-r59usk02 1847 6 Group Group NNP cord-014516-r59usk02 1847 7 B B NNP cord-014516-r59usk02 1847 8 ) ) -RRB- cord-014516-r59usk02 1847 9 received receive VBD cord-014516-r59usk02 1847 10 placebo placebo NN cord-014516-r59usk02 1847 11 following follow VBG cord-014516-r59usk02 1847 12 the the DT cord-014516-r59usk02 1847 13 same same JJ cord-014516-r59usk02 1847 14 protocol protocol NN cord-014516-r59usk02 1847 15 . . . cord-014516-r59usk02 1848 1 Blood blood NN cord-014516-r59usk02 1848 2 pressure pressure NN cord-014516-r59usk02 1848 3 was be VBD cord-014516-r59usk02 1848 4 measured measure VBN cord-014516-r59usk02 1848 5 using use VBG cord-014516-r59usk02 1848 6 high high JJ cord-014516-r59usk02 1848 7 definition definition NN cord-014516-r59usk02 1848 8 oscillometry oscillometry NN cord-014516-r59usk02 1848 9 . . . cord-014516-r59usk02 1849 1 A a DT cord-014516-r59usk02 1849 2 responder responder NN cord-014516-r59usk02 1849 3 was be VBD cord-014516-r59usk02 1849 4 defined define VBN cord-014516-r59usk02 1849 5 as as IN cord-014516-r59usk02 1849 6 a a DT cord-014516-r59usk02 1849 7 cat cat NN cord-014516-r59usk02 1849 8 showing show VBG cord-014516-r59usk02 1849 9 a a DT cord-014516-r59usk02 1849 10 decrease decrease NN cord-014516-r59usk02 1849 11 of of IN cord-014516-r59usk02 1849 12 systolic systolic JJ cord-014516-r59usk02 1849 13 blood blood NN cord-014516-r59usk02 1849 14 pressure pressure NN cord-014516-r59usk02 1849 15 ( ( -LRB- cord-014516-r59usk02 1849 16 SBP SBP NNP cord-014516-r59usk02 1849 17 ) ) -RRB- cord-014516-r59usk02 1849 18 to to IN cord-014516-r59usk02 1849 19 ≤150 ≤150 NN cord-014516-r59usk02 1849 20 mmHg mmHg NNS cord-014516-r59usk02 1849 21 or or CC cord-014516-r59usk02 1849 22 a a DT cord-014516-r59usk02 1849 23 decrease decrease NN cord-014516-r59usk02 1849 24 from from IN cord-014516-r59usk02 1849 25 baseline baseline NN cord-014516-r59usk02 1849 26 of of IN cord-014516-r59usk02 1849 27 ≥15 ≥15 NNP cord-014516-r59usk02 1849 28 % % NN cord-014516-r59usk02 1849 29 . . . cord-014516-r59usk02 1850 1 Following follow VBG cord-014516-r59usk02 1850 2 day day NN cord-014516-r59usk02 1850 3 28 28 CD cord-014516-r59usk02 1850 4 ( ( -LRB- cord-014516-r59usk02 1850 5 phase phase NN cord-014516-r59usk02 1850 6 2 2 CD cord-014516-r59usk02 1850 7 ) ) -RRB- cord-014516-r59usk02 1850 8 , , , cord-014516-r59usk02 1850 9 Group Group NNP cord-014516-r59usk02 1850 10 A A NNP cord-014516-r59usk02 1850 11 continued continue VBD cord-014516-r59usk02 1850 12 on on IN cord-014516-r59usk02 1850 13 amlodipine amlodipine NN cord-014516-r59usk02 1850 14 and and CC cord-014516-r59usk02 1850 15 Group Group NNP cord-014516-r59usk02 1850 16 B B NNP cord-014516-r59usk02 1850 17 switched switch VBD cord-014516-r59usk02 1850 18 to to IN cord-014516-r59usk02 1850 19 amlodipine amlodipine NN cord-014516-r59usk02 1850 20 and and CC cord-014516-r59usk02 1850 21 the the DT cord-014516-r59usk02 1850 22 dose dose NN cord-014516-r59usk02 1850 23 was be VBD cord-014516-r59usk02 1850 24 adjusted adjust VBN cord-014516-r59usk02 1850 25 as as IN cord-014516-r59usk02 1850 26 per per IN cord-014516-r59usk02 1850 27 phase phase NN cord-014516-r59usk02 1850 28 1 1 CD cord-014516-r59usk02 1850 29 . . . cord-014516-r59usk02 1851 1 Both both DT cord-014516-r59usk02 1851 2 groups group NNS cord-014516-r59usk02 1851 3 were be VBD cord-014516-r59usk02 1851 4 followed follow VBN cord-014516-r59usk02 1851 5 for for IN cord-014516-r59usk02 1851 6 90 90 CD cord-014516-r59usk02 1851 7 days day NNS cord-014516-r59usk02 1851 8 on on IN cord-014516-r59usk02 1851 9 amlodipine amlodipine NN cord-014516-r59usk02 1851 10 . . . cord-014516-r59usk02 1852 1 Blood blood NN cord-014516-r59usk02 1852 2 was be VBD cord-014516-r59usk02 1852 3 collected collect VBN cord-014516-r59usk02 1852 4 at at IN cord-014516-r59usk02 1852 5 days day NNS cord-014516-r59usk02 1852 6 28 28 CD cord-014516-r59usk02 1852 7 ( ( -LRB- cord-014516-r59usk02 1852 8 Group Group NNP cord-014516-r59usk02 1852 9 A A NNP cord-014516-r59usk02 1852 10 ) ) -RRB- cord-014516-r59usk02 1852 11 and and CC cord-014516-r59usk02 1852 12 90 90 CD cord-014516-r59usk02 1852 13 ( ( -LRB- cord-014516-r59usk02 1852 14 both both DT cord-014516-r59usk02 1852 15 Groups group NNS cord-014516-r59usk02 1852 16 ) ) -RRB- cord-014516-r59usk02 1852 17 and and CC cord-014516-r59usk02 1852 18 serum serum NN cord-014516-r59usk02 1852 19 [ [ -LRB- cord-014516-r59usk02 1852 20 amlodipine amlodipine NN cord-014516-r59usk02 1852 21 ] ] -RRB- cord-014516-r59usk02 1852 22 measured measure VBN cord-014516-r59usk02 1852 23 by by IN cord-014516-r59usk02 1852 24 liquid liquid JJ cord-014516-r59usk02 1852 25 chromatography chromatography NN cord-014516-r59usk02 1852 26 mass mass NN cord-014516-r59usk02 1852 27 spectrometry spectrometry NN cord-014516-r59usk02 1852 28 . . . cord-014516-r59usk02 1853 1 The the DT cord-014516-r59usk02 1853 2 SBP SBP NNP cord-014516-r59usk02 1853 3 measured measure VBD cord-014516-r59usk02 1853 4 on on IN cord-014516-r59usk02 1853 5 treatment treatment NN cord-014516-r59usk02 1853 6 was be VBD cord-014516-r59usk02 1853 7 calculated calculate VBN cord-014516-r59usk02 1853 8 as as IN cord-014516-r59usk02 1853 9 percentage percentage NN cord-014516-r59usk02 1853 10 of of IN cord-014516-r59usk02 1853 11 the the DT cord-014516-r59usk02 1853 12 baseline baseline JJ cord-014516-r59usk02 1853 13 SBP SBP NNP cord-014516-r59usk02 1853 14 and and CC cord-014516-r59usk02 1853 15 plotted plot VBD cord-014516-r59usk02 1853 16 against against IN cord-014516-r59usk02 1853 17 serum serum NN cord-014516-r59usk02 1853 18 [ [ -LRB- cord-014516-r59usk02 1853 19 amlodipine amlodipine NN cord-014516-r59usk02 1853 20 ] ] -RRB- cord-014516-r59usk02 1853 21 using use VBG cord-014516-r59usk02 1853 22 a a DT cord-014516-r59usk02 1853 23 sigmoidal sigmoidal JJ cord-014516-r59usk02 1853 24 Emax Emax NNP cord-014516-r59usk02 1853 25 model model NN cord-014516-r59usk02 1853 26 ( ( -LRB- cord-014516-r59usk02 1853 27 WinNonLin winnonlin NN cord-014516-r59usk02 1853 28 software software NN cord-014516-r59usk02 1853 29 ) ) -RRB- cord-014516-r59usk02 1853 30 . . . cord-014516-r59usk02 1854 1 Data datum NNS cord-014516-r59usk02 1854 2 are be VBP cord-014516-r59usk02 1854 3 expressed express VBN cord-014516-r59usk02 1854 4 as as IN cord-014516-r59usk02 1854 5 mean mean JJ cord-014516-r59usk02 1854 6 AE AE NNP cord-014516-r59usk02 1854 7 SE SE NNP cord-014516-r59usk02 1854 8 . . . cord-014516-r59usk02 1855 1 The the DT cord-014516-r59usk02 1855 2 serum serum NN cord-014516-r59usk02 1855 3 concentrations concentration NNS cord-014516-r59usk02 1855 4 of of IN cord-014516-r59usk02 1855 5 Group Group NNP cord-014516-r59usk02 1855 6 A a DT cord-014516-r59usk02 1855 7 cats cat NNS cord-014516-r59usk02 1855 8 that that WDT cord-014516-r59usk02 1855 9 remained remain VBD cord-014516-r59usk02 1855 10 on on IN cord-014516-r59usk02 1855 11 0.125 0.125 CD cord-014516-r59usk02 1855 12 mg mg NNP cord-014516-r59usk02 1855 13 / / SYM cord-014516-r59usk02 1855 14 kg kg NNS cord-014516-r59usk02 1855 15 were be VBD cord-014516-r59usk02 1855 16 29.8 29.8 CD cord-014516-r59usk02 1855 17 AE AE NNP cord-014516-r59usk02 1855 18 2.5 2.5 CD cord-014516-r59usk02 1855 19 ng ng NN cord-014516-r59usk02 1855 20 / / SYM cord-014516-r59usk02 1855 21 ml ml XX cord-014516-r59usk02 1855 22 whereas whereas IN cord-014516-r59usk02 1855 23 those those DT cord-014516-r59usk02 1855 24 switched switch VBD cord-014516-r59usk02 1855 25 to to IN cord-014516-r59usk02 1855 26 0.25 0.25 CD cord-014516-r59usk02 1855 27 mg mg NNP cord-014516-r59usk02 1855 28 / / SYM cord-014516-r59usk02 1855 29 kg kg NNS cord-014516-r59usk02 1855 30 were be VBD cord-014516-r59usk02 1855 31 51.2 51.2 CD cord-014516-r59usk02 1855 32 AE AE NNP cord-014516-r59usk02 1855 33 7.8 7.8 CD cord-014516-r59usk02 1855 34 ng ng NN cord-014516-r59usk02 1855 35 / / SYM cord-014516-r59usk02 1855 36 ml ml NN cord-014516-r59usk02 1855 37 . . . cord-014516-r59usk02 1856 1 When when WRB cord-014516-r59usk02 1856 2 data datum NNS cord-014516-r59usk02 1856 3 from from IN cord-014516-r59usk02 1856 4 groups group NNS cord-014516-r59usk02 1856 5 A A NNP cord-014516-r59usk02 1856 6 and and CC cord-014516-r59usk02 1856 7 B B NNP cord-014516-r59usk02 1856 8 were be VBD cord-014516-r59usk02 1856 9 pooled pool VBN cord-014516-r59usk02 1856 10 , , , cord-014516-r59usk02 1856 11 a a DT cord-014516-r59usk02 1856 12 sigmoidal sigmoidal JJ cord-014516-r59usk02 1856 13 relationship relationship NN cord-014516-r59usk02 1856 14 between between IN cord-014516-r59usk02 1856 15 percentage percentage NN cord-014516-r59usk02 1856 16 baseline baseline JJ cord-014516-r59usk02 1856 17 SBP SBP NNP cord-014516-r59usk02 1856 18 and and CC cord-014516-r59usk02 1856 19 serum serum NN cord-014516-r59usk02 1856 20 [ [ -LRB- cord-014516-r59usk02 1856 21 amlodipine amlodipine NN cord-014516-r59usk02 1856 22 ] ] -RRB- cord-014516-r59usk02 1856 23 was be VBD cord-014516-r59usk02 1856 24 found find VBN cord-014516-r59usk02 1856 25 . . . cord-014516-r59usk02 1857 1 Estimated estimate VBN cord-014516-r59usk02 1857 2 values value NNS cord-014516-r59usk02 1857 3 of of IN cord-014516-r59usk02 1857 4 lowest low JJS cord-014516-r59usk02 1857 5 percentage percentage NN cord-014516-r59usk02 1857 6 baseline baseline JJ cord-014516-r59usk02 1857 7 blood blood NN cord-014516-r59usk02 1857 8 pressure pressure NN cord-014516-r59usk02 1857 9 on on IN cord-014516-r59usk02 1857 10 treatment treatment NN cord-014516-r59usk02 1857 11 ( ( -LRB- cord-014516-r59usk02 1857 12 Emax Emax NNP cord-014516-r59usk02 1857 13 ) ) -RRB- cord-014516-r59usk02 1857 14 was be VBD cord-014516-r59usk02 1857 15 83.1 83.1 CD cord-014516-r59usk02 1857 16 AE AE NNP cord-014516-r59usk02 1857 17 1.7 1.7 CD cord-014516-r59usk02 1857 18 % % NN cord-014516-r59usk02 1857 19 , , , cord-014516-r59usk02 1857 20 with with IN cord-014516-r59usk02 1857 21 an an DT cord-014516-r59usk02 1857 22 EC EC NNP cord-014516-r59usk02 1857 23 50 50 CD cord-014516-r59usk02 1857 24 value value NN cord-014516-r59usk02 1857 25 of of IN cord-014516-r59usk02 1857 26 10.4 10.4 CD cord-014516-r59usk02 1857 27 AE AE NNP cord-014516-r59usk02 1857 28 2.6 2.6 CD cord-014516-r59usk02 1857 29 ng/ ng/ NN cord-014516-r59usk02 1857 30 ml ml NN cord-014516-r59usk02 1857 31 and and CC cord-014516-r59usk02 1857 32 a a DT cord-014516-r59usk02 1857 33 slope slope NN cord-014516-r59usk02 1857 34 function function NN cord-014516-r59usk02 1857 35 of of IN cord-014516-r59usk02 1857 36 2.5 2.5 CD cord-014516-r59usk02 1857 37 AE AE NNP cord-014516-r59usk02 1857 38 1.2 1.2 CD cord-014516-r59usk02 1857 39 . . . cord-014516-r59usk02 1858 1 The the DT cord-014516-r59usk02 1858 2 serum serum NN cord-014516-r59usk02 1858 3 concentration concentration NN cord-014516-r59usk02 1858 4 required require VBN cord-014516-r59usk02 1858 5 to to TO cord-014516-r59usk02 1858 6 reduce reduce VB cord-014516-r59usk02 1858 7 blood blood NN cord-014516-r59usk02 1858 8 pressure pressure NN cord-014516-r59usk02 1858 9 by by IN cord-014516-r59usk02 1858 10 15 15 CD cord-014516-r59usk02 1858 11 % % NN cord-014516-r59usk02 1858 12 was be VBD cord-014516-r59usk02 1858 13 estimated estimate VBN cord-014516-r59usk02 1858 14 to to TO cord-014516-r59usk02 1858 15 be be VB cord-014516-r59usk02 1858 16 20 20 CD cord-014516-r59usk02 1858 17 ng ng NN cord-014516-r59usk02 1858 18 / / SYM cord-014516-r59usk02 1858 19 ml ml NN cord-014516-r59usk02 1858 20 . . . cord-014516-r59usk02 1859 1 The the DT cord-014516-r59usk02 1859 2 present present JJ cord-014516-r59usk02 1859 3 study study NN cord-014516-r59usk02 1859 4 related relate VBN cord-014516-r59usk02 1859 5 blood blood NN cord-014516-r59usk02 1859 6 pressure pressure NN cord-014516-r59usk02 1859 7 reduction reduction NN cord-014516-r59usk02 1859 8 to to IN cord-014516-r59usk02 1859 9 serum serum NN cord-014516-r59usk02 1859 10 [ [ -LRB- cord-014516-r59usk02 1859 11 amlodipine amlodipine NN cord-014516-r59usk02 1859 12 ] ] -RRB- cord-014516-r59usk02 1859 13 in in IN cord-014516-r59usk02 1859 14 feline feline JJ cord-014516-r59usk02 1859 15 clinical clinical JJ cord-014516-r59usk02 1859 16 hypertension hypertension NN cord-014516-r59usk02 1859 17 . . . cord-014516-r59usk02 1860 1 The the DT cord-014516-r59usk02 1860 2 limitations limitation NNS cord-014516-r59usk02 1860 3 of of IN cord-014516-r59usk02 1860 4 this this DT cord-014516-r59usk02 1860 5 study study NN cord-014516-r59usk02 1860 6 were be VBD cord-014516-r59usk02 1860 7 the the DT cord-014516-r59usk02 1860 8 limited limited JJ cord-014516-r59usk02 1860 9 number number NN cord-014516-r59usk02 1860 10 of of IN cord-014516-r59usk02 1860 11 blood blood NN cord-014516-r59usk02 1860 12 samples sample NNS cord-014516-r59usk02 1860 13 collected collect VBN cord-014516-r59usk02 1860 14 and and CC cord-014516-r59usk02 1860 15 lack lack NN cord-014516-r59usk02 1860 16 of of IN cord-014516-r59usk02 1860 17 information information NN cord-014516-r59usk02 1860 18 relating relate VBG cord-014516-r59usk02 1860 19 to to IN cord-014516-r59usk02 1860 20 the the DT cord-014516-r59usk02 1860 21 exact exact JJ cord-014516-r59usk02 1860 22 timing timing NN cord-014516-r59usk02 1860 23 of of IN cord-014516-r59usk02 1860 24 blood blood NN cord-014516-r59usk02 1860 25 sampling sampling NN cord-014516-r59usk02 1860 26 relative relative JJ cord-014516-r59usk02 1860 27 to to IN cord-014516-r59usk02 1860 28 dosing dose VBG cord-014516-r59usk02 1860 29 in in IN cord-014516-r59usk02 1860 30 some some DT cord-014516-r59usk02 1860 31 cats cat NNS cord-014516-r59usk02 1860 32 . . . cord-014516-r59usk02 1861 1 However however RB cord-014516-r59usk02 1861 2 , , , cord-014516-r59usk02 1861 3 these these DT cord-014516-r59usk02 1861 4 data datum NNS cord-014516-r59usk02 1861 5 could could MD cord-014516-r59usk02 1861 6 be be VB cord-014516-r59usk02 1861 7 used use VBN cord-014516-r59usk02 1861 8 to to TO cord-014516-r59usk02 1861 9 define define VB cord-014516-r59usk02 1861 10 appropriate appropriate JJ cord-014516-r59usk02 1861 11 therapeutic therapeutic JJ cord-014516-r59usk02 1861 12 serum serum NN cord-014516-r59usk02 1861 13 [ [ -LRB- cord-014516-r59usk02 1861 14 amlodipine amlodipine NN cord-014516-r59usk02 1861 15 ] ] -RRB- cord-014516-r59usk02 1861 16 in in IN cord-014516-r59usk02 1861 17 hypertensive hypertensive JJ cord-014516-r59usk02 1861 18 cats cat NNS cord-014516-r59usk02 1861 19 . . . cord-014516-r59usk02 1862 1 M M NNP cord-014516-r59usk02 1862 2 Huhtinen Huhtinen NNP cord-014516-r59usk02 1862 3 is be VBZ cord-014516-r59usk02 1862 4 an an DT cord-014516-r59usk02 1862 5 employee employee NN cord-014516-r59usk02 1862 6 of of IN cord-014516-r59usk02 1862 7 the the DT cord-014516-r59usk02 1862 8 sponsor sponsor NN cord-014516-r59usk02 1862 9 ; ; : cord-014516-r59usk02 1862 10 J. J. NNP cord-014516-r59usk02 1862 11 Elliott Elliott NNP cord-014516-r59usk02 1862 12 has have VBZ cord-014516-r59usk02 1862 13 the the DT cord-014516-r59usk02 1862 14 following follow VBG cord-014516-r59usk02 1862 15 information information NN cord-014516-r59usk02 1862 16 to to TO cord-014516-r59usk02 1862 17 disclose disclose VB cord-014516-r59usk02 1862 18 : : : cord-014516-r59usk02 1862 19 Consultancy consultancy NN cord-014516-r59usk02 1862 20 : : : cord-014516-r59usk02 1862 21 Pfizer Pfizer NNP cord-014516-r59usk02 1862 22 Animal Animal NNP cord-014516-r59usk02 1862 23 Health Health NNP cord-014516-r59usk02 1862 24 / / SYM cord-014516-r59usk02 1862 25 Zoetis Zoetis NNP cord-014516-r59usk02 1862 26 , , , cord-014516-r59usk02 1862 27 CEVA CEVA NNP cord-014516-r59usk02 1862 28 Animal Animal NNP cord-014516-r59usk02 1862 29 Health Health NNP cord-014516-r59usk02 1862 30 , , , cord-014516-r59usk02 1862 31 Boehringer Boehringer NNP cord-014516-r59usk02 1862 32 Ingelheim Ingelheim NNP cord-014516-r59usk02 1862 33 , , , cord-014516-r59usk02 1862 34 Vetoquinol Vetoquinol NNP cord-014516-r59usk02 1862 35 Ltd Ltd NNP cord-014516-r59usk02 1862 36 , , , cord-014516-r59usk02 1862 37 Orion Orion NNP cord-014516-r59usk02 1862 38 Ltd. Ltd. NNP cord-014516-r59usk02 1862 39 , , , cord-014516-r59usk02 1862 40 Elanco Elanco NNP cord-014516-r59usk02 1862 41 Ltd Ltd NNP cord-014516-r59usk02 1862 42 , , , cord-014516-r59usk02 1862 43 Idexx Idexx NNP cord-014516-r59usk02 1862 44 Ltd Ltd NNP cord-014516-r59usk02 1862 45 , , , cord-014516-r59usk02 1863 1 Niche Niche NNP cord-014516-r59usk02 1863 2 Generics Generics NNPS cord-014516-r59usk02 1863 3 Ltd. Ltd. NNP cord-014516-r59usk02 1863 4 Triveristas Triveristas NNP cord-014516-r59usk02 1863 5 Ltd. Ltd. NNP cord-014516-r59usk02 1863 6 , , , cord-014516-r59usk02 1863 7 Virbac Virbac NNP cord-014516-r59usk02 1863 8 Ltd. Ltd. NNP cord-014516-r59usk02 1863 9 , , , cord-014516-r59usk02 1863 10 Advisory Advisory NNP cord-014516-r59usk02 1863 11 board board NN cord-014516-r59usk02 1863 12 membership membership NN cord-014516-r59usk02 1863 13 : : : cord-014516-r59usk02 1864 1 International International NNP cord-014516-r59usk02 1864 2 Renal Renal NNP cord-014516-r59usk02 1864 3 Interest Interest NNP cord-014516-r59usk02 1864 4 Society Society NNP cord-014516-r59usk02 1864 5 ( ( -LRB- cord-014516-r59usk02 1864 6 supported support VBN cord-014516-r59usk02 1864 7 by by IN cord-014516-r59usk02 1864 8 Novartis Novartis NNP cord-014516-r59usk02 1864 9 ) ) -RRB- cord-014516-r59usk02 1865 1 European European NNP cord-014516-r59usk02 1865 2 Emesis Emesis NNP cord-014516-r59usk02 1865 3 Council Council NNP cord-014516-r59usk02 1865 4 ( ( -LRB- cord-014516-r59usk02 1865 5 sponsored sponsor VBN cord-014516-r59usk02 1865 6 by by IN cord-014516-r59usk02 1865 7 Pfizer Pfizer NNP cord-014516-r59usk02 1865 8 Animal Animal NNP cord-014516-r59usk02 1865 9 Health Health NNP cord-014516-r59usk02 1865 10 -now -now : cord-014516-r59usk02 1866 1 Zoetis Zoetis NNP cord-014516-r59usk02 1866 2 ) ) -RRB- cord-014516-r59usk02 1867 1 Cardiorenal Cardiorenal NNP cord-014516-r59usk02 1867 2 Board Board NNP cord-014516-r59usk02 1868 1 -Vetoquinol -Vetoquinol . cord-014516-r59usk02 1869 1 Ltd. Ltd. NNP cord-014516-r59usk02 1870 1 Idexx Idexx NNP cord-014516-r59usk02 1870 2 Renal Renal NNP cord-014516-r59usk02 1870 3 Advisory Advisory NNP cord-014516-r59usk02 1870 4 Board Board NNP cord-014516-r59usk02 1870 5 Research Research NNP cord-014516-r59usk02 1870 6 Grants Grants NNPS cord-014516-r59usk02 1870 7 or or CC cord-014516-r59usk02 1870 8 contracts contract NNS cord-014516-r59usk02 1870 9 : : : cord-014516-r59usk02 1870 10 Vetoquinol Vetoquinol NNP cord-014516-r59usk02 1870 11 Ltd Ltd NNP cord-014516-r59usk02 1870 12 , , , cord-014516-r59usk02 1870 13 Novartis Novartis NNP cord-014516-r59usk02 1870 14 Ltd Ltd NNP cord-014516-r59usk02 1870 15 , , , cord-014516-r59usk02 1870 16 Pfizer Pfizer NNP cord-014516-r59usk02 1870 17 Animal Animal NNP cord-014516-r59usk02 1870 18 Health Health NNP cord-014516-r59usk02 1870 19 Ltd Ltd NNP cord-014516-r59usk02 1870 20 ( ( -LRB- cord-014516-r59usk02 1870 21 now now RB cord-014516-r59usk02 1870 22 Zoetis Zoetis NNP cord-014516-r59usk02 1870 23 ) ) -RRB- cord-014516-r59usk02 1870 24 , , , cord-014516-r59usk02 1870 25 Royal Royal NNP cord-014516-r59usk02 1870 26 Canin Canin NNP cord-014516-r59usk02 1870 27 Ltd Ltd NNP cord-014516-r59usk02 1870 28 , , , cord-014516-r59usk02 1870 29 Boeringher Boeringher NNP cord-014516-r59usk02 1870 30 Ingelheim Ingelheim NNP cord-014516-r59usk02 1870 31 Ltd Ltd NNP cord-014516-r59usk02 1870 32 , , , cord-014516-r59usk02 1870 33 Waltham Waltham NNP cord-014516-r59usk02 1870 34 Centre Centre NNP cord-014516-r59usk02 1870 35 for for IN cord-014516-r59usk02 1870 36 Pet Pet NNP cord-014516-r59usk02 1870 37 Nutrition Nutrition NNP cord-014516-r59usk02 1870 38 , , , cord-014516-r59usk02 1870 39 CEVA CEVA NNP cord-014516-r59usk02 1870 40 Animal Animal NNP cord-014516-r59usk02 1870 41 Health Health NNP cord-014516-r59usk02 1870 42 Orion Orion NNP cord-014516-r59usk02 1870 43 Ltd. Ltd. NNP cord-014516-r59usk02 1870 44 ; ; : cord-014516-r59usk02 1870 45 L L NNP cord-014516-r59usk02 1870 46 Pelligand Pelligand NNP cord-014516-r59usk02 1870 47 has have VBZ cord-014516-r59usk02 1870 48 the the DT cord-014516-r59usk02 1870 49 following follow VBG cord-014516-r59usk02 1870 50 information information NN cord-014516-r59usk02 1870 51 to to TO cord-014516-r59usk02 1870 52 disclose disclose VB cord-014516-r59usk02 1870 53 : : : cord-014516-r59usk02 1870 54 In in IN cord-014516-r59usk02 1870 55 receipt receipt NN cord-014516-r59usk02 1870 56 of of IN cord-014516-r59usk02 1870 57 research research NN cord-014516-r59usk02 1870 58 grant grant NN cord-014516-r59usk02 1870 59 / / SYM cord-014516-r59usk02 1870 60 contract contract NN cord-014516-r59usk02 1870 61 funding funding NN cord-014516-r59usk02 1870 62 from from IN cord-014516-r59usk02 1870 63 Orion Orion NNP cord-014516-r59usk02 1870 64 Ltd. Ltd. NNP cord-014516-r59usk02 1870 65 , , , cord-014516-r59usk02 1870 66 Novartis Novartis NNP cord-014516-r59usk02 1870 67 Animal Animal NNP cord-014516-r59usk02 1870 68 Health Health NNP cord-014516-r59usk02 1870 69 , , , cord-014516-r59usk02 1870 70 Transpharmation Transpharmation NNP cord-014516-r59usk02 1870 71 Ltd Ltd NNP cord-014516-r59usk02 1870 72 , , , cord-014516-r59usk02 1870 73 DeltaDOT DeltaDOT NNP cord-014516-r59usk02 1870 74 Ltd Ltd NNP cord-014516-r59usk02 1870 75 ; ; : cord-014516-r59usk02 1870 76 Acted act VBD cord-014516-r59usk02 1870 77 as as IN cord-014516-r59usk02 1870 78 a a DT cord-014516-r59usk02 1870 79 consultant consultant NN cord-014516-r59usk02 1870 80 for for IN cord-014516-r59usk02 1870 81 : : : cord-014516-r59usk02 1870 82 Triveritas Triveritas NNP cord-014516-r59usk02 1870 83 Ltd. Ltd. NNP cord-014516-r59usk02 1870 84 and and CC cord-014516-r59usk02 1870 85 Novartis Novartis NNP cord-014516-r59usk02 1870 86 Animal Animal NNP cord-014516-r59usk02 1870 87 Health Health NNP cord-014516-r59usk02 1870 88 . . . cord-014516-r59usk02 1871 1 Commercial commercial JJ cord-014516-r59usk02 1871 2 assays assay NNS cord-014516-r59usk02 1871 3 for for IN cord-014516-r59usk02 1871 4 the the DT cord-014516-r59usk02 1871 5 measurement measurement NN cord-014516-r59usk02 1871 6 of of IN cord-014516-r59usk02 1871 7 canine canine JJ cord-014516-r59usk02 1871 8 and and CC cord-014516-r59usk02 1871 9 feline feline JJ cord-014516-r59usk02 1871 10 pancreatic pancreatic JJ cord-014516-r59usk02 1871 11 lipase lipase NN cord-014516-r59usk02 1871 12 immunoreactivity immunoreactivity NN cord-014516-r59usk02 1871 13 ( ( -LRB- cord-014516-r59usk02 1871 14 Spec spec NN cord-014516-r59usk02 1871 15 cPL cPL NNS cord-014516-r59usk02 1871 16 â â NFP cord-014516-r59usk02 1871 17 and and CC cord-014516-r59usk02 1871 18 Spec Spec NNP cord-014516-r59usk02 1871 19 fPL fPL NNP cord-014516-r59usk02 1871 20 â â NFP cord-014516-r59usk02 1871 21 , , , cord-014516-r59usk02 1871 22 respectively respectively RB cord-014516-r59usk02 1872 1 ; ; : cord-014516-r59usk02 1872 2 Idexx Idexx NNP cord-014516-r59usk02 1872 3 Laboratories Laboratories NNP cord-014516-r59usk02 1872 4 , , , cord-014516-r59usk02 1872 5 Westbrook Westbrook NNP cord-014516-r59usk02 1872 6 , , , cord-014516-r59usk02 1872 7 ME ME NNP cord-014516-r59usk02 1872 8 , , , cord-014516-r59usk02 1872 9 USA USA NNP cord-014516-r59usk02 1872 10 ) ) -RRB- cord-014516-r59usk02 1872 11 have have VBP cord-014516-r59usk02 1872 12 been be VBN cord-014516-r59usk02 1872 13 available available JJ cord-014516-r59usk02 1872 14 for for IN cord-014516-r59usk02 1872 15 a a DT cord-014516-r59usk02 1872 16 few few JJ cord-014516-r59usk02 1872 17 years year NNS cord-014516-r59usk02 1872 18 and and CC cord-014516-r59usk02 1872 19 have have VBP cord-014516-r59usk02 1872 20 previously previously RB cord-014516-r59usk02 1872 21 been be VBN cord-014516-r59usk02 1872 22 analytically analytically RB cord-014516-r59usk02 1872 23 and and CC cord-014516-r59usk02 1872 24 clinically clinically RB cord-014516-r59usk02 1872 25 validated validated JJ cord-014516-r59usk02 1872 26 . . . cord-014516-r59usk02 1873 1 Recently recently RB cord-014516-r59usk02 1873 2 , , , cord-014516-r59usk02 1873 3 new new JJ cord-014516-r59usk02 1873 4 commercial commercial JJ cord-014516-r59usk02 1873 5 assays assay NNS cord-014516-r59usk02 1873 6 for for IN cord-014516-r59usk02 1873 7 the the DT cord-014516-r59usk02 1873 8 measurement measurement NN cord-014516-r59usk02 1873 9 of of IN cord-014516-r59usk02 1873 10 these these DT cord-014516-r59usk02 1873 11 parameters parameter NNS cord-014516-r59usk02 1873 12 have have VBP cord-014516-r59usk02 1873 13 become become VBN cord-014516-r59usk02 1873 14 available available JJ cord-014516-r59usk02 1873 15 , , , cord-014516-r59usk02 1873 16 though though IN cord-014516-r59usk02 1873 17 neither neither DT cord-014516-r59usk02 1873 18 one one CD cord-014516-r59usk02 1873 19 of of IN cord-014516-r59usk02 1873 20 these these DT cord-014516-r59usk02 1873 21 assays assay NNS cord-014516-r59usk02 1873 22 have have VBP cord-014516-r59usk02 1873 23 been be VBN cord-014516-r59usk02 1873 24 analytically analytically RB cord-014516-r59usk02 1873 25 or or CC cord-014516-r59usk02 1873 26 clinically clinically RB cord-014516-r59usk02 1873 27 validated validate VBN cord-014516-r59usk02 1873 28 in in IN cord-014516-r59usk02 1873 29 the the DT cord-014516-r59usk02 1873 30 literature literature NN cord-014516-r59usk02 1873 31 . . . cord-014516-r59usk02 1874 1 Thus thus RB cord-014516-r59usk02 1874 2 , , , cord-014516-r59usk02 1874 3 the the DT cord-014516-r59usk02 1874 4 goal goal NN cord-014516-r59usk02 1874 5 of of IN cord-014516-r59usk02 1874 6 this this DT cord-014516-r59usk02 1874 7 study study NN cord-014516-r59usk02 1874 8 was be VBD cord-014516-r59usk02 1874 9 to to TO cord-014516-r59usk02 1874 10 compare compare VB cord-014516-r59usk02 1874 11 these these DT cord-014516-r59usk02 1874 12 newly newly RB cord-014516-r59usk02 1874 13 available available JJ cord-014516-r59usk02 1874 14 assays assay NNS cord-014516-r59usk02 1874 15 to to IN cord-014516-r59usk02 1874 16 the the DT cord-014516-r59usk02 1874 17 established establish VBN cord-014516-r59usk02 1874 18 assays assay NNS cord-014516-r59usk02 1874 19 . . . cord-014516-r59usk02 1875 1 Leftover leftover JJ cord-014516-r59usk02 1875 2 serum serum NN cord-014516-r59usk02 1875 3 samples sample NNS cord-014516-r59usk02 1875 4 from from IN cord-014516-r59usk02 1875 5 diagnostic diagnostic JJ cord-014516-r59usk02 1875 6 submissions submission NNS cord-014516-r59usk02 1875 7 to to IN cord-014516-r59usk02 1875 8 the the DT cord-014516-r59usk02 1875 9 GI GI NNP cord-014516-r59usk02 1875 10 Laboratory Laboratory NNP cord-014516-r59usk02 1875 11 were be VBD cord-014516-r59usk02 1875 12 collected collect VBN cord-014516-r59usk02 1875 13 based base VBN cord-014516-r59usk02 1875 14 on on IN cord-014516-r59usk02 1875 15 certain certain JJ cord-014516-r59usk02 1875 16 parameters parameter NNS cord-014516-r59usk02 1875 17 ( ( -LRB- cord-014516-r59usk02 1875 18 e.g. e.g. RB cord-014516-r59usk02 1875 19 , , , cord-014516-r59usk02 1875 20 results result NNS cord-014516-r59usk02 1875 21 throughout throughout IN cord-014516-r59usk02 1875 22 the the DT cord-014516-r59usk02 1875 23 working working NN cord-014516-r59usk02 1875 24 range range NN cord-014516-r59usk02 1875 25 of of IN cord-014516-r59usk02 1875 26 the the DT cord-014516-r59usk02 1875 27 assay assay NN cord-014516-r59usk02 1875 28 , , , cord-014516-r59usk02 1875 29 good good JJ cord-014516-r59usk02 1875 30 quality quality NN cord-014516-r59usk02 1875 31 sample sample NN cord-014516-r59usk02 1875 32 or or CC cord-014516-r59usk02 1875 33 hemolytic hemolytic JJ cord-014516-r59usk02 1875 34 , , , cord-014516-r59usk02 1875 35 lipemic lipemic NNP cord-014516-r59usk02 1875 36 , , , cord-014516-r59usk02 1875 37 or or CC cord-014516-r59usk02 1875 38 icteric icteric JJ cord-014516-r59usk02 1875 39 sample sample NN cord-014516-r59usk02 1875 40 ) ) -RRB- cord-014516-r59usk02 1875 41 and and CC cord-014516-r59usk02 1875 42 were be VBD cord-014516-r59usk02 1875 43 assigned assign VBN cord-014516-r59usk02 1875 44 random random JJ cord-014516-r59usk02 1875 45 sample sample NN cord-014516-r59usk02 1875 46 ID ID NNP cord-014516-r59usk02 1875 47 numbers number NNS cord-014516-r59usk02 1875 48 . . . cord-014516-r59usk02 1876 1 The the DT cord-014516-r59usk02 1876 2 samples sample NNS cord-014516-r59usk02 1876 3 were be VBD cord-014516-r59usk02 1876 4 evaluated evaluate VBN cord-014516-r59usk02 1876 5 by by IN cord-014516-r59usk02 1876 6 Spec Spec NNP cord-014516-r59usk02 1876 7 cPL cPL NNS cord-014516-r59usk02 1876 8 â â NFP cord-014516-r59usk02 1876 9 or or CC cord-014516-r59usk02 1876 10 Spec Spec NNP cord-014516-r59usk02 1876 11 fPL fPL NNP cord-014516-r59usk02 1876 12 â â NFP cord-014516-r59usk02 1876 13 , , , cord-014516-r59usk02 1876 14 sent send VBN cord-014516-r59usk02 1876 15 on on RP cord-014516-r59usk02 1876 16 dry dry JJ cord-014516-r59usk02 1876 17 ice ice NN cord-014516-r59usk02 1876 18 to to IN cord-014516-r59usk02 1876 19 the the DT cord-014516-r59usk02 1876 20 Klinik Klinik NNP cord-014516-r59usk02 1876 21 am be VBP cord-014516-r59usk02 1876 22 Hochberg Hochberg NNP cord-014516-r59usk02 1876 23 , , , cord-014516-r59usk02 1876 24 and and CC cord-014516-r59usk02 1876 25 one one CD cord-014516-r59usk02 1876 26 aliquot aliquot NN cord-014516-r59usk02 1876 27 of of IN cord-014516-r59usk02 1876 28 each each DT cord-014516-r59usk02 1876 29 sample sample NN cord-014516-r59usk02 1876 30 was be VBD cord-014516-r59usk02 1876 31 blindly blindly RB cord-014516-r59usk02 1876 32 submitted submit VBN cord-014516-r59usk02 1876 33 to to IN cord-014516-r59usk02 1876 34 Laboklin Laboklin NNP cord-014516-r59usk02 1876 35 for for IN cord-014516-r59usk02 1876 36 measurement measurement NN cord-014516-r59usk02 1876 37 of of IN cord-014516-r59usk02 1876 38 cPLI cpli NN cord-014516-r59usk02 1876 39 and and CC cord-014516-r59usk02 1876 40 fPLI fpli VB cord-014516-r59usk02 1876 41 by by IN cord-014516-r59usk02 1876 42 their -PRON- PRP$ cord-014516-r59usk02 1876 43 newly newly RB cord-014516-r59usk02 1876 44 released release VBN cord-014516-r59usk02 1876 45 in in IN cord-014516-r59usk02 1876 46 - - HYPH cord-014516-r59usk02 1876 47 house house NN cord-014516-r59usk02 1876 48 assay assay NN cord-014516-r59usk02 1876 49 and and CC cord-014516-r59usk02 1876 50 also also RB cord-014516-r59usk02 1876 51 to to IN cord-014516-r59usk02 1876 52 the the DT cord-014516-r59usk02 1876 53 GI GI NNP cord-014516-r59usk02 1876 54 Lab Lab NNP cord-014516-r59usk02 1876 55 at at IN cord-014516-r59usk02 1876 56 Texas Texas NNP cord-014516-r59usk02 1876 57 A&M A&M NNP cord-014516-r59usk02 1876 58 University University NNP cord-014516-r59usk02 1876 59 for for IN cord-014516-r59usk02 1876 60 repeated repeat VBN cord-014516-r59usk02 1876 61 analysis analysis NN cord-014516-r59usk02 1876 62 by by IN cord-014516-r59usk02 1876 63 Spec Spec NNP cord-014516-r59usk02 1876 64 cPL cPL NNS cord-014516-r59usk02 1876 65 â â NFP cord-014516-r59usk02 1876 66 and and CC cord-014516-r59usk02 1876 67 Spec Spec NNP cord-014516-r59usk02 1876 68 fPL fPL NNP cord-014516-r59usk02 1876 69 â â , cord-014516-r59usk02 1876 70 to to TO cord-014516-r59usk02 1876 71 exclude exclude VB cord-014516-r59usk02 1876 72 any any DT cord-014516-r59usk02 1876 73 effect effect NN cord-014516-r59usk02 1876 74 of of IN cord-014516-r59usk02 1876 75 shipping shipping NN cord-014516-r59usk02 1876 76 . . . cord-014516-r59usk02 1877 1 There there EX cord-014516-r59usk02 1877 2 was be VBD cord-014516-r59usk02 1877 3 no no DT cord-014516-r59usk02 1877 4 significant significant JJ cord-014516-r59usk02 1877 5 difference difference NN cord-014516-r59usk02 1877 6 between between IN cord-014516-r59usk02 1877 7 serum serum NN cord-014516-r59usk02 1877 8 cPLI cPLI NNS cord-014516-r59usk02 1877 9 or or CC cord-014516-r59usk02 1877 10 fPLI fpli NN cord-014516-r59usk02 1877 11 concentrations concentration NNS cord-014516-r59usk02 1877 12 before before IN cord-014516-r59usk02 1877 13 or or CC cord-014516-r59usk02 1877 14 after after IN cord-014516-r59usk02 1877 15 shipping ship VBG cord-014516-r59usk02 1877 16 at at IN cord-014516-r59usk02 1877 17 the the DT cord-014516-r59usk02 1877 18 GI GI NNP cord-014516-r59usk02 1877 19 Lab Lab NNP cord-014516-r59usk02 1877 20 ( ( -LRB- cord-014516-r59usk02 1877 21 pvalues pvalue NNS cord-014516-r59usk02 1877 22 for for IN cord-014516-r59usk02 1877 23 Wilcoxon Wilcoxon NNP cord-014516-r59usk02 1878 1 matched match VBN cord-014516-r59usk02 1878 2 - - HYPH cord-014516-r59usk02 1878 3 pairs pair NNS cord-014516-r59usk02 1878 4 signed sign VBN cord-014516-r59usk02 1878 5 rank rank NN cord-014516-r59usk02 1878 6 tests test NNS cord-014516-r59usk02 1878 7 : : : cord-014516-r59usk02 1878 8 0.593 0.593 CD cord-014516-r59usk02 1878 9 and and CC cord-014516-r59usk02 1878 10 0.672 0.672 CD cord-014516-r59usk02 1878 11 , , , cord-014516-r59usk02 1878 12 respectively respectively RB cord-014516-r59usk02 1878 13 ) ) -RRB- cord-014516-r59usk02 1878 14 . . . cord-014516-r59usk02 1879 1 In in IN cord-014516-r59usk02 1879 2 contrast contrast NN cord-014516-r59usk02 1879 3 , , , cord-014516-r59usk02 1879 4 there there EX cord-014516-r59usk02 1879 5 was be VBD cord-014516-r59usk02 1879 6 a a DT cord-014516-r59usk02 1879 7 significant significant JJ cord-014516-r59usk02 1879 8 difference difference NN cord-014516-r59usk02 1879 9 between between IN cord-014516-r59usk02 1879 10 serum serum NN cord-014516-r59usk02 1879 11 cPLI cPLI NNS cord-014516-r59usk02 1879 12 or or CC cord-014516-r59usk02 1879 13 fPLI fpli NN cord-014516-r59usk02 1879 14 concentrations concentration NNS cord-014516-r59usk02 1879 15 between between IN cord-014516-r59usk02 1879 16 the the DT cord-014516-r59usk02 1879 17 newly newly RB cord-014516-r59usk02 1879 18 released release VBN cord-014516-r59usk02 1879 19 assays assay NNS cord-014516-r59usk02 1879 20 and and CC cord-014516-r59usk02 1879 21 the the DT cord-014516-r59usk02 1879 22 previously previously RB cord-014516-r59usk02 1879 23 established establish VBN cord-014516-r59usk02 1879 24 assays assay NNS cord-014516-r59usk02 1879 25 ( ( -LRB- cord-014516-r59usk02 1879 26 pvalues pvalues NNP cord-014516-r59usk02 1879 27 < < XX cord-014516-r59usk02 1879 28 0.0001 0.0001 CD cord-014516-r59usk02 1879 29 and and CC cord-014516-r59usk02 1879 30 0.0241 0.0241 CD cord-014516-r59usk02 1879 31 , , , cord-014516-r59usk02 1879 32 respectively respectively RB cord-014516-r59usk02 1879 33 ) ) -RRB- cord-014516-r59usk02 1879 34 . . . cord-014516-r59usk02 1880 1 While while IN cord-014516-r59usk02 1880 2 there there EX cord-014516-r59usk02 1880 3 was be VBD cord-014516-r59usk02 1880 4 a a DT cord-014516-r59usk02 1880 5 significant significant JJ cord-014516-r59usk02 1880 6 correlation correlation NN cord-014516-r59usk02 1880 7 between between IN cord-014516-r59usk02 1880 8 the the DT cord-014516-r59usk02 1880 9 newly newly RB cord-014516-r59usk02 1880 10 released release VBN cord-014516-r59usk02 1880 11 and and CC cord-014516-r59usk02 1880 12 the the DT cord-014516-r59usk02 1880 13 previously previously RB cord-014516-r59usk02 1880 14 released release VBN cord-014516-r59usk02 1880 15 assays assay NNS cord-014516-r59usk02 1880 16 ( ( -LRB- cord-014516-r59usk02 1880 17 Spearman Spearman NNP cord-014516-r59usk02 1880 18 r r NN cord-014516-r59usk02 1880 19 : : : cord-014516-r59usk02 1880 20 0.775 0.775 CD cord-014516-r59usk02 1880 21 and and CC cord-014516-r59usk02 1880 22 0.7386 0.7386 CD cord-014516-r59usk02 1880 23 , , , cord-014516-r59usk02 1880 24 respectively respectively RB cord-014516-r59usk02 1880 25 ) ) -RRB- cord-014516-r59usk02 1880 26 , , , cord-014516-r59usk02 1880 27 this this DT cord-014516-r59usk02 1880 28 correlation correlation NN cord-014516-r59usk02 1880 29 was be VBD cord-014516-r59usk02 1880 30 very very RB cord-014516-r59usk02 1880 31 poor poor JJ cord-014516-r59usk02 1880 32 for for IN cord-014516-r59usk02 1880 33 assays assay NNS cord-014516-r59usk02 1880 34 that that WDT cord-014516-r59usk02 1880 35 supposedly supposedly RB cord-014516-r59usk02 1880 36 measure measure VBP cord-014516-r59usk02 1880 37 the the DT cord-014516-r59usk02 1880 38 same same JJ cord-014516-r59usk02 1880 39 analyte analyte NN cord-014516-r59usk02 1880 40 . . . cord-014516-r59usk02 1881 1 Also also RB cord-014516-r59usk02 1881 2 , , , cord-014516-r59usk02 1881 3 the the DT cord-014516-r59usk02 1881 4 interpretation interpretation NN cord-014516-r59usk02 1881 5 for for IN cord-014516-r59usk02 1881 6 serum serum NN cord-014516-r59usk02 1881 7 cPLI cPLI NNS cord-014516-r59usk02 1881 8 and and CC cord-014516-r59usk02 1881 9 fPLI fpli NN cord-014516-r59usk02 1881 10 results result NNS cord-014516-r59usk02 1881 11 between between IN cord-014516-r59usk02 1881 12 the the DT cord-014516-r59usk02 1881 13 previously previously RB cord-014516-r59usk02 1881 14 developed develop VBN cord-014516-r59usk02 1881 15 assays assay NNS cord-014516-r59usk02 1881 16 and and CC cord-014516-r59usk02 1881 17 the the DT cord-014516-r59usk02 1881 18 new new JJ cord-014516-r59usk02 1881 19 assays assay NNS cord-014516-r59usk02 1881 20 did do VBD cord-014516-r59usk02 1881 21 not not RB cord-014516-r59usk02 1881 22 agree agree VB cord-014516-r59usk02 1881 23 for for IN cord-014516-r59usk02 1881 24 many many JJ cord-014516-r59usk02 1881 25 of of IN cord-014516-r59usk02 1881 26 the the DT cord-014516-r59usk02 1881 27 samples sample NNS cord-014516-r59usk02 1881 28 . . . cord-014516-r59usk02 1882 1 Finally finally RB cord-014516-r59usk02 1882 2 , , , cord-014516-r59usk02 1882 3 both both DT cord-014516-r59usk02 1882 4 newly newly RB cord-014516-r59usk02 1882 5 developed develop VBN cord-014516-r59usk02 1882 6 assays assay NNS cord-014516-r59usk02 1882 7 showed show VBD cord-014516-r59usk02 1882 8 some some DT cord-014516-r59usk02 1882 9 erratic erratic JJ cord-014516-r59usk02 1882 10 results result NNS cord-014516-r59usk02 1882 11 . . . cord-014516-r59usk02 1883 1 In in IN cord-014516-r59usk02 1883 2 conclusion conclusion NN cord-014516-r59usk02 1883 3 , , , cord-014516-r59usk02 1883 4 the the DT cord-014516-r59usk02 1883 5 newly newly RB cord-014516-r59usk02 1883 6 released release VBN cord-014516-r59usk02 1883 7 assays assay NNS cord-014516-r59usk02 1883 8 for for IN cord-014516-r59usk02 1883 9 the the DT cord-014516-r59usk02 1883 10 measurement measurement NN cord-014516-r59usk02 1883 11 of of IN cord-014516-r59usk02 1883 12 cPLI cpli NN cord-014516-r59usk02 1883 13 and and CC cord-014516-r59usk02 1883 14 fPLI fpli NN cord-014516-r59usk02 1883 15 do do VBP cord-014516-r59usk02 1883 16 not not RB cord-014516-r59usk02 1883 17 agree agree VB cord-014516-r59usk02 1883 18 with with IN cord-014516-r59usk02 1883 19 previously previously RB cord-014516-r59usk02 1883 20 established establish VBN cord-014516-r59usk02 1883 21 and and CC cord-014516-r59usk02 1883 22 validated validate VBN cord-014516-r59usk02 1883 23 assays assay NNS cord-014516-r59usk02 1883 24 , , , cord-014516-r59usk02 1883 25 provide provide VB cord-014516-r59usk02 1883 26 different different JJ cord-014516-r59usk02 1883 27 interpretations interpretation NNS cord-014516-r59usk02 1883 28 , , , cord-014516-r59usk02 1883 29 and and CC cord-014516-r59usk02 1883 30 show show VB cord-014516-r59usk02 1883 31 erratic erratic JJ cord-014516-r59usk02 1883 32 results result NNS cord-014516-r59usk02 1883 33 . . . cord-014516-r59usk02 1884 1 Thus thus RB cord-014516-r59usk02 1884 2 , , , cord-014516-r59usk02 1884 3 further further JJ cord-014516-r59usk02 1884 4 research research NN cord-014516-r59usk02 1884 5 is be VBZ cord-014516-r59usk02 1884 6 needed need VBN cord-014516-r59usk02 1884 7 before before IN cord-014516-r59usk02 1884 8 these these DT cord-014516-r59usk02 1884 9 newly newly RB cord-014516-r59usk02 1884 10 released release VBN cord-014516-r59usk02 1884 11 assays assay NNS cord-014516-r59usk02 1884 12 could could MD cord-014516-r59usk02 1884 13 be be VB cord-014516-r59usk02 1884 14 recommended recommend VBN cord-014516-r59usk02 1884 15 for for IN cord-014516-r59usk02 1884 16 clinical clinical JJ cord-014516-r59usk02 1884 17 use use NN cord-014516-r59usk02 1884 18 . . . cord-014516-r59usk02 1885 1 Dr. Dr. NNP cord-014516-r59usk02 1885 2 Steiner Steiner NNP cord-014516-r59usk02 1885 3 serves serve VBZ cord-014516-r59usk02 1885 4 as as IN cord-014516-r59usk02 1885 5 Director Director NNP cord-014516-r59usk02 1885 6 and and CC cord-014516-r59usk02 1885 7 Dr. Dr. NNP cord-014516-r59usk02 1885 8 Suchodolski Suchodolski NNP cord-014516-r59usk02 1885 9 serves serve VBZ cord-014516-r59usk02 1885 10 as as IN cord-014516-r59usk02 1885 11 Associate Associate NNP cord-014516-r59usk02 1885 12 Director Director NNP cord-014516-r59usk02 1885 13 of of IN cord-014516-r59usk02 1885 14 the the DT cord-014516-r59usk02 1885 15 Gastrointestinal Gastrointestinal NNP cord-014516-r59usk02 1885 16 Laboratory Laboratory NNP cord-014516-r59usk02 1885 17 at at IN cord-014516-r59usk02 1885 18 texas texas NNP cord-014516-r59usk02 1885 19 A&M A&M NNP cord-014516-r59usk02 1885 20 University University NNP cord-014516-r59usk02 1885 21 . . . cord-014516-r59usk02 1886 1 Dr. Dr. NNP cord-014516-r59usk02 1886 2 Steiner Steiner NNP cord-014516-r59usk02 1886 3 also also RB cord-014516-r59usk02 1886 4 serves serve VBZ cord-014516-r59usk02 1886 5 as as IN cord-014516-r59usk02 1886 6 a a DT cord-014516-r59usk02 1886 7 paid pay VBN cord-014516-r59usk02 1886 8 consultant consultant NN cord-014516-r59usk02 1886 9 to to IN cord-014516-r59usk02 1886 10 Idexx Idexx NNP cord-014516-r59usk02 1886 11 Laboratories Laboratories NNP cord-014516-r59usk02 1886 12 , , , cord-014516-r59usk02 1886 13 Westbrook Westbrook NNP cord-014516-r59usk02 1886 14 , , , cord-014516-r59usk02 1886 15 ME ME NNP cord-014516-r59usk02 1886 16 , , , cord-014516-r59usk02 1886 17 USA USA NNP cord-014516-r59usk02 1886 18 . . . cord-014516-r59usk02 1887 1 Both both DT cord-014516-r59usk02 1887 2 the the DT cord-014516-r59usk02 1887 3 Gastrointestinal Gastrointestinal NNP cord-014516-r59usk02 1887 4 Laboratory Laboratory NNP cord-014516-r59usk02 1887 5 and and CC cord-014516-r59usk02 1887 6 Idexx Idexx NNP cord-014516-r59usk02 1887 7 Laboratories Laboratories NNPS cord-014516-r59usk02 1887 8 offer offer VBP cord-014516-r59usk02 1887 9 cPLI cPLI NNS cord-014516-r59usk02 1887 10 and and CC cord-014516-r59usk02 1887 11 fPLI fpli NN cord-014516-r59usk02 1887 12 testing testing NN cord-014516-r59usk02 1887 13 on on IN cord-014516-r59usk02 1887 14 a a DT cord-014516-r59usk02 1887 15 fee fee NN cord-014516-r59usk02 1887 16 - - HYPH cord-014516-r59usk02 1887 17 for for IN cord-014516-r59usk02 1887 18 - - HYPH cord-014516-r59usk02 1887 19 service service NN cord-014516-r59usk02 1887 20 basis basis NN cord-014516-r59usk02 1887 21 . . . cord-014516-r59usk02 1888 1 Digestive digestive JJ cord-014516-r59usk02 1888 2 health health NN cord-014516-r59usk02 1888 3 is be VBZ cord-014516-r59usk02 1888 4 a a DT cord-014516-r59usk02 1888 5 main main JJ cord-014516-r59usk02 1888 6 concern concern NN cord-014516-r59usk02 1888 7 for for IN cord-014516-r59usk02 1888 8 growth growth NN cord-014516-r59usk02 1888 9 , , , cord-014516-r59usk02 1888 10 morbidity morbidity NN cord-014516-r59usk02 1888 11 and and CC cord-014516-r59usk02 1888 12 mortality mortality NN cord-014516-r59usk02 1888 13 in in IN cord-014516-r59usk02 1888 14 weaning wean VBG cord-014516-r59usk02 1888 15 puppies puppy NNS cord-014516-r59usk02 1888 16 . . . cord-014516-r59usk02 1889 1 Fecal fecal JJ cord-014516-r59usk02 1889 2 immunoglobulin immunoglobulin NN cord-014516-r59usk02 1889 3 A a NN cord-014516-r59usk02 1889 4 ( ( -LRB- cord-014516-r59usk02 1889 5 IgA IgA NNP cord-014516-r59usk02 1889 6 ) ) -RRB- cord-014516-r59usk02 1889 7 has have VBZ cord-014516-r59usk02 1889 8 been be VBN cord-014516-r59usk02 1889 9 suggested suggest VBN cord-014516-r59usk02 1889 10 as as IN cord-014516-r59usk02 1889 11 a a DT cord-014516-r59usk02 1889 12 useful useful JJ cord-014516-r59usk02 1889 13 noninvasive noninvasive JJ cord-014516-r59usk02 1889 14 biomarker biomarker NN cord-014516-r59usk02 1889 15 for for IN cord-014516-r59usk02 1889 16 mucosal mucosal JJ cord-014516-r59usk02 1889 17 immunity immunity NN cord-014516-r59usk02 1889 18 . . . cord-014516-r59usk02 1890 1 The the DT cord-014516-r59usk02 1890 2 purpose purpose NN cord-014516-r59usk02 1890 3 of of IN cord-014516-r59usk02 1890 4 this this DT cord-014516-r59usk02 1890 5 study study NN cord-014516-r59usk02 1890 6 was be VBD cord-014516-r59usk02 1890 7 to to TO cord-014516-r59usk02 1890 8 evaluate evaluate VB cord-014516-r59usk02 1890 9 the the DT cord-014516-r59usk02 1890 10 effect effect NN cord-014516-r59usk02 1890 11 of of IN cord-014516-r59usk02 1890 12 infection infection NN cord-014516-r59usk02 1890 13 with with IN cord-014516-r59usk02 1890 14 enteropathogens enteropathogen NNS cord-014516-r59usk02 1890 15 on on IN cord-014516-r59usk02 1890 16 fecal fecal JJ cord-014516-r59usk02 1890 17 IgA IgA NNP cord-014516-r59usk02 1890 18 concentrations concentration NNS cord-014516-r59usk02 1890 19 in in IN cord-014516-r59usk02 1890 20 puppies puppy NNS cord-014516-r59usk02 1890 21 and and CC cord-014516-r59usk02 1890 22 that that IN cord-014516-r59usk02 1890 23 of of IN cord-014516-r59usk02 1890 24 physiological physiological JJ cord-014516-r59usk02 1890 25 factors factor NNS cord-014516-r59usk02 1890 26 such such JJ cord-014516-r59usk02 1890 27 as as IN cord-014516-r59usk02 1890 28 age age NN cord-014516-r59usk02 1890 29 and and CC cord-014516-r59usk02 1890 30 breed breed NN cord-014516-r59usk02 1890 31 size size NN cord-014516-r59usk02 1890 32 . . . cord-014516-r59usk02 1891 1 282 282 CD cord-014516-r59usk02 1891 2 puppies puppy NNS cord-014516-r59usk02 1891 3 from from IN cord-014516-r59usk02 1891 4 33 33 CD cord-014516-r59usk02 1891 5 breeding breeding NN cord-014516-r59usk02 1891 6 kennels kennel NNS cord-014516-r59usk02 1891 7 were be VBD cord-014516-r59usk02 1891 8 included include VBN cord-014516-r59usk02 1891 9 in in IN cord-014516-r59usk02 1891 10 the the DT cord-014516-r59usk02 1891 11 study study NN cord-014516-r59usk02 1891 12 . . . cord-014516-r59usk02 1892 1 Puppies puppy NNS cord-014516-r59usk02 1892 2 were be VBD cord-014516-r59usk02 1892 3 between between IN cord-014516-r59usk02 1892 4 5 5 CD cord-014516-r59usk02 1892 5 and and CC cord-014516-r59usk02 1892 6 14 14 CD cord-014516-r59usk02 1892 7 weeks week NNS cord-014516-r59usk02 1892 8 of of IN cord-014516-r59usk02 1892 9 age age NN cord-014516-r59usk02 1893 1 ( ( -LRB- cord-014516-r59usk02 1893 2 meanAEStandard meanaestandard CD cord-014516-r59usk02 1893 3 Deviation deviation NN cord-014516-r59usk02 1893 4 ( ( -LRB- cord-014516-r59usk02 1893 5 SD sd NN cord-014516-r59usk02 1893 6 ) ) -RRB- cord-014516-r59usk02 1893 7 : : : cord-014516-r59usk02 1893 8 7.8 7.8 CD cord-014516-r59usk02 1893 9 AE AE NNP cord-014516-r59usk02 1893 10 1.5 1.5 CD cord-014516-r59usk02 1893 11 weeks week NNS cord-014516-r59usk02 1893 12 ) ) -RRB- cord-014516-r59usk02 1893 13 . . . cord-014516-r59usk02 1894 1 Depending depend VBG cord-014516-r59usk02 1894 2 on on IN cord-014516-r59usk02 1894 3 the the DT cord-014516-r59usk02 1894 4 mean mean JJ cord-014516-r59usk02 1894 5 adult adult NN cord-014516-r59usk02 1894 6 body body NN cord-014516-r59usk02 1894 7 weight weight NN cord-014516-r59usk02 1894 8 of of IN cord-014516-r59usk02 1894 9 their -PRON- PRP$ cord-014516-r59usk02 1894 10 respective respective JJ cord-014516-r59usk02 1894 11 breed breed NN cord-014516-r59usk02 1894 12 , , , cord-014516-r59usk02 1894 13 the the DT cord-014516-r59usk02 1894 14 puppies puppy NNS cord-014516-r59usk02 1894 15 were be VBD cord-014516-r59usk02 1894 16 divided divide VBN cord-014516-r59usk02 1894 17 into into IN cord-014516-r59usk02 1894 18 small small JJ cord-014516-r59usk02 1894 19 ( ( -LRB- cord-014516-r59usk02 1894 20 if if IN cord-014516-r59usk02 1894 21 mean mean JJ cord-014516-r59usk02 1894 22 adult adult NN cord-014516-r59usk02 1894 23 body body NN cord-014516-r59usk02 1894 24 weight weight NN cord-014516-r59usk02 1894 25 < < XX cord-014516-r59usk02 1894 26 25 25 CD cord-014516-r59usk02 1894 27 kg kg NNS cord-014516-r59usk02 1894 28 ) ) -RRB- cord-014516-r59usk02 1894 29 or or CC cord-014516-r59usk02 1894 30 large large JJ cord-014516-r59usk02 1894 31 ( ( -LRB- cord-014516-r59usk02 1894 32 > > NFP cord-014516-r59usk02 1894 33 25 25 CD cord-014516-r59usk02 1894 34 kg kg NNS cord-014516-r59usk02 1894 35 ) ) -RRB- cord-014516-r59usk02 1894 36 breed breed NN cord-014516-r59usk02 1894 37 puppies puppy NNS cord-014516-r59usk02 1894 38 . . . cord-014516-r59usk02 1895 1 For for IN cord-014516-r59usk02 1895 2 each each DT cord-014516-r59usk02 1895 3 puppy puppy NN cord-014516-r59usk02 1895 4 , , , cord-014516-r59usk02 1895 5 fecal fecal JJ cord-014516-r59usk02 1895 6 consistency consistency NN cord-014516-r59usk02 1895 7 was be VBD cord-014516-r59usk02 1895 8 evaluated evaluate VBN cord-014516-r59usk02 1895 9 using use VBG cord-014516-r59usk02 1895 10 a a DT cord-014516-r59usk02 1895 11 13-point 13-point JJ cord-014516-r59usk02 1895 12 scale scale NN cord-014516-r59usk02 1895 13 and and CC cord-014516-r59usk02 1895 14 feces fece NNS cord-014516-r59usk02 1895 15 were be VBD cord-014516-r59usk02 1895 16 collected collect VBN cord-014516-r59usk02 1895 17 for for IN cord-014516-r59usk02 1895 18 the the DT cord-014516-r59usk02 1895 19 evaluation evaluation NN cord-014516-r59usk02 1895 20 of of IN cord-014516-r59usk02 1895 21 presence presence NN cord-014516-r59usk02 1895 22 of of IN cord-014516-r59usk02 1895 23 fecal fecal JJ cord-014516-r59usk02 1895 24 enteropathogens enteropathogen NNS cord-014516-r59usk02 1895 25 and and CC cord-014516-r59usk02 1895 26 fecal fecal JJ cord-014516-r59usk02 1895 27 IgA IgA NNP cord-014516-r59usk02 1895 28 concentrations concentration NNS cord-014516-r59usk02 1895 29 . . . cord-014516-r59usk02 1896 1 The the DT cord-014516-r59usk02 1896 2 presence presence NN cord-014516-r59usk02 1896 3 of of IN cord-014516-r59usk02 1896 4 enteropathogens enteropathogen NNS cord-014516-r59usk02 1896 5 in in IN cord-014516-r59usk02 1896 6 fecal fecal JJ cord-014516-r59usk02 1896 7 samples sample NNS cord-014516-r59usk02 1896 8 was be VBD cord-014516-r59usk02 1896 9 evaluated evaluate VBN cord-014516-r59usk02 1896 10 by by IN cord-014516-r59usk02 1896 11 qPCR qPCR NNP cord-014516-r59usk02 1896 12 for for IN cord-014516-r59usk02 1896 13 canine canine JJ cord-014516-r59usk02 1896 14 parvovirus parvovirus NN cord-014516-r59usk02 1896 15 type type NN cord-014516-r59usk02 1896 16 2 2 CD cord-014516-r59usk02 1896 17 ( ( -LRB- cord-014516-r59usk02 1896 18 CPV2 CPV2 NNP cord-014516-r59usk02 1896 19 ) ) -RRB- cord-014516-r59usk02 1896 20 , , , cord-014516-r59usk02 1896 21 qRT qRT NNP cord-014516-r59usk02 1896 22 - - HYPH cord-014516-r59usk02 1896 23 PCR PCR NNP cord-014516-r59usk02 1896 24 for for IN cord-014516-r59usk02 1896 25 canine canine JJ cord-014516-r59usk02 1896 26 coronavirus coronavirus NN cord-014516-r59usk02 1896 27 ( ( -LRB- cord-014516-r59usk02 1896 28 CCV CCV NNP cord-014516-r59usk02 1896 29 ) ) -RRB- cord-014516-r59usk02 1896 30 , , , cord-014516-r59usk02 1896 31 coproantigen coproantigen NNP cord-014516-r59usk02 1896 32 quantification quantification NN cord-014516-r59usk02 1896 33 for for IN cord-014516-r59usk02 1896 34 Giardia Giardia NNP cord-014516-r59usk02 1896 35 ( ( -LRB- cord-014516-r59usk02 1896 36 ProSpecT ProSpecT NNP cord-014516-r59usk02 1896 37 - - HYPH cord-014516-r59usk02 1896 38 Giardia Giardia NNP cord-014516-r59usk02 1896 39 , , , cord-014516-r59usk02 1896 40 Remel Remel NNP cord-014516-r59usk02 1896 41 ) ) -RRB- cord-014516-r59usk02 1896 42 , , , cord-014516-r59usk02 1896 43 and and CC cord-014516-r59usk02 1896 44 McMaster McMaster NNP cord-014516-r59usk02 1896 45 flotation flotation NN cord-014516-r59usk02 1896 46 technique technique NN cord-014516-r59usk02 1896 47 for for IN cord-014516-r59usk02 1896 48 other other JJ cord-014516-r59usk02 1896 49 parasite parasite NN cord-014516-r59usk02 1896 50 eggs egg NNS cord-014516-r59usk02 1896 51 and and CC cord-014516-r59usk02 1896 52 oocysts oocyst NNS cord-014516-r59usk02 1896 53 . . . cord-014516-r59usk02 1897 1 Fecal fecal JJ cord-014516-r59usk02 1897 2 IgA IgA NNP cord-014516-r59usk02 1897 3 concentrations concentration NNS cord-014516-r59usk02 1897 4 were be VBD cord-014516-r59usk02 1897 5 measured measure VBN cord-014516-r59usk02 1897 6 by by IN cord-014516-r59usk02 1897 7 an an DT cord-014516-r59usk02 1897 8 ELISA ELISA NNP cord-014516-r59usk02 1897 9 test test NN cord-014516-r59usk02 1897 10 . . . cord-014516-r59usk02 1898 1 Statistical statistical JJ cord-014516-r59usk02 1898 2 analyses analysis NNS cord-014516-r59usk02 1898 3 were be VBD cord-014516-r59usk02 1898 4 performed perform VBN cord-014516-r59usk02 1898 5 using use VBG cord-014516-r59usk02 1898 6 SAS SAS NNP cord-014516-r59usk02 1898 7 software software NN cord-014516-r59usk02 1898 8 . . . cord-014516-r59usk02 1899 1 A a DT cord-014516-r59usk02 1899 2 linear linear JJ cord-014516-r59usk02 1899 3 mixed mixed JJ cord-014516-r59usk02 1899 4 model model NN cord-014516-r59usk02 1899 5 ( ( -LRB- cord-014516-r59usk02 1899 6 proc proc VB cord-014516-r59usk02 1899 7 MIXED MIXED NNP cord-014516-r59usk02 1899 8 ) ) -RRB- cord-014516-r59usk02 1899 9 with with IN cord-014516-r59usk02 1899 10 fecal fecal JJ cord-014516-r59usk02 1899 11 IgA IgA NNP cord-014516-r59usk02 1899 12 concentration concentration NN cord-014516-r59usk02 1899 13 as as IN cord-014516-r59usk02 1899 14 outcome outcome NN cord-014516-r59usk02 1899 15 was be VBD cord-014516-r59usk02 1899 16 used use VBN cord-014516-r59usk02 1899 17 to to TO cord-014516-r59usk02 1899 18 determine determine VB cord-014516-r59usk02 1899 19 the the DT cord-014516-r59usk02 1899 20 following follow VBG cord-014516-r59usk02 1899 21 effects effect NNS cord-014516-r59usk02 1899 22 : : : cord-014516-r59usk02 1899 23 enteropathogen enteropathogen NN cord-014516-r59usk02 1899 24 infection infection NN cord-014516-r59usk02 1899 25 , , , cord-014516-r59usk02 1899 26 breed breed NN cord-014516-r59usk02 1899 27 size size NN cord-014516-r59usk02 1899 28 , , , cord-014516-r59usk02 1899 29 age age NN cord-014516-r59usk02 1899 30 , , , cord-014516-r59usk02 1899 31 and and CC cord-014516-r59usk02 1899 32 fecal fecal JJ cord-014516-r59usk02 1899 33 score score NN cord-014516-r59usk02 1899 34 . . . cord-014516-r59usk02 1900 1 The the DT cord-014516-r59usk02 1900 2 respective respective JJ cord-014516-r59usk02 1900 3 influence influence NN cord-014516-r59usk02 1900 4 of of IN cord-014516-r59usk02 1900 5 litter litter NN cord-014516-r59usk02 1900 6 and and CC cord-014516-r59usk02 1900 7 breeding breeding NN cord-014516-r59usk02 1900 8 kennel kennel NN cord-014516-r59usk02 1900 9 as as IN cord-014516-r59usk02 1900 10 random random JJ cord-014516-r59usk02 1900 11 effects effect NNS cord-014516-r59usk02 1900 12 was be VBD cord-014516-r59usk02 1900 13 also also RB cord-014516-r59usk02 1900 14 determined determine VBN cord-014516-r59usk02 1900 15 . . . cord-014516-r59usk02 1901 1 Data Data NNP cord-014516-r59usk02 1901 2 is be VBZ cord-014516-r59usk02 1901 3 presented present VBN cord-014516-r59usk02 1901 4 as as IN cord-014516-r59usk02 1901 5 mean mean JJ cord-014516-r59usk02 1901 6 AE AE NNP cord-014516-r59usk02 1901 7 SD SD NNP cord-014516-r59usk02 1901 8 . . . cord-014516-r59usk02 1902 1 Small small JJ cord-014516-r59usk02 1902 2 breed breed NN cord-014516-r59usk02 1902 3 dogs dog NNS cord-014516-r59usk02 1902 4 represented represent VBD cord-014516-r59usk02 1902 5 27.3 27.3 CD cord-014516-r59usk02 1902 6 % % NN cord-014516-r59usk02 1902 7 ( ( -LRB- cord-014516-r59usk02 1902 8 77/282 77/282 CD cord-014516-r59usk02 1902 9 ) ) -RRB- cord-014516-r59usk02 1902 10 of of IN cord-014516-r59usk02 1902 11 the the DT cord-014516-r59usk02 1902 12 total total JJ cord-014516-r59usk02 1902 13 number number NN cord-014516-r59usk02 1902 14 of of IN cord-014516-r59usk02 1902 15 dogs dog NNS cord-014516-r59usk02 1902 16 included include VBN cord-014516-r59usk02 1902 17 . . . cord-014516-r59usk02 1903 1 At at RB cord-014516-r59usk02 1903 2 least least RBS cord-014516-r59usk02 1903 3 one one CD cord-014516-r59usk02 1903 4 enteropathogen enteropathogen NN cord-014516-r59usk02 1903 5 was be VBD cord-014516-r59usk02 1903 6 identified identify VBN cord-014516-r59usk02 1903 7 in in IN cord-014516-r59usk02 1903 8 76.2 76.2 CD cord-014516-r59usk02 1903 9 % % NN cord-014516-r59usk02 1903 10 of of IN cord-014516-r59usk02 1903 11 puppies puppy NNS cord-014516-r59usk02 1903 12 ( ( -LRB- cord-014516-r59usk02 1903 13 214/281 214/281 CD cord-014516-r59usk02 1903 14 ) ) -RRB- cord-014516-r59usk02 1903 15 . . . cord-014516-r59usk02 1904 1 Fecal fecal JJ cord-014516-r59usk02 1904 2 IgA IgA NNP cord-014516-r59usk02 1904 3 concentration concentration NN cord-014516-r59usk02 1904 4 was be VBD cord-014516-r59usk02 1904 5 significantly significantly RB cord-014516-r59usk02 1904 6 influenced influence VBN cord-014516-r59usk02 1904 7 by by IN cord-014516-r59usk02 1904 8 fecal fecal JJ cord-014516-r59usk02 1904 9 enteropathogens enteropathogen NNS cord-014516-r59usk02 1904 10 ( ( -LRB- cord-014516-r59usk02 1904 11 p p NN cord-014516-r59usk02 1904 12 = = SYM cord-014516-r59usk02 1904 13 0.037 0.037 CD cord-014516-r59usk02 1904 14 ) ) -RRB- cord-014516-r59usk02 1904 15 . . . cord-014516-r59usk02 1905 1 Puppies puppy NNS cord-014516-r59usk02 1905 2 infected infect VBN cord-014516-r59usk02 1905 3 with with IN cord-014516-r59usk02 1905 4 at at RB cord-014516-r59usk02 1905 5 least least RBS cord-014516-r59usk02 1905 6 one one CD cord-014516-r59usk02 1905 7 enteropathogen enteropathogen NN cord-014516-r59usk02 1905 8 had have VBD cord-014516-r59usk02 1905 9 significantly significantly RB cord-014516-r59usk02 1905 10 lower low JJR cord-014516-r59usk02 1905 11 fecal fecal JJ cord-014516-r59usk02 1905 12 IgA IgA NNP cord-014516-r59usk02 1905 13 concentrations concentration NNS cord-014516-r59usk02 1905 14 than than IN cord-014516-r59usk02 1905 15 puppies puppy NNS cord-014516-r59usk02 1905 16 without without IN cord-014516-r59usk02 1905 17 any any DT cord-014516-r59usk02 1905 18 enteropathogens enteropathogen NNS cord-014516-r59usk02 1905 19 ( ( -LRB- cord-014516-r59usk02 1905 20 5.0 5.0 CD cord-014516-r59usk02 1905 21 AE AE NNP cord-014516-r59usk02 1905 22 4.4 4.4 CD cord-014516-r59usk02 1905 23 lg lg NNP cord-014516-r59usk02 1905 24 / / SYM cord-014516-r59usk02 1905 25 g g NN cord-014516-r59usk02 1905 26 vs. vs. NN cord-014516-r59usk02 1905 27 6.9 6.9 CD cord-014516-r59usk02 1905 28 AE AE NNP cord-014516-r59usk02 1905 29 5.5 5.5 CD cord-014516-r59usk02 1905 30 lg lg NN cord-014516-r59usk02 1905 31 / / SYM cord-014516-r59usk02 1905 32 g g NN cord-014516-r59usk02 1905 33 ) ) -RRB- cord-014516-r59usk02 1905 34 . . . cord-014516-r59usk02 1906 1 Breed Breed NNP cord-014516-r59usk02 1906 2 ( ( -LRB- cord-014516-r59usk02 1906 3 p p NN cord-014516-r59usk02 1906 4 = = SYM cord-014516-r59usk02 1906 5 0.029 0.029 CD cord-014516-r59usk02 1906 6 ) ) -RRB- cord-014516-r59usk02 1906 7 , , , cord-014516-r59usk02 1906 8 but but CC cord-014516-r59usk02 1906 9 not not RB cord-014516-r59usk02 1906 10 age age NN cord-014516-r59usk02 1906 11 ( ( -LRB- cord-014516-r59usk02 1906 12 p p NN cord-014516-r59usk02 1906 13 = = SYM cord-014516-r59usk02 1906 14 0.082 0.082 CD cord-014516-r59usk02 1906 15 ) ) -RRB- cord-014516-r59usk02 1906 16 , , , cord-014516-r59usk02 1906 17 influenced influence VBD cord-014516-r59usk02 1906 18 IgA IgA NNP cord-014516-r59usk02 1906 19 concentration concentration NN cord-014516-r59usk02 1906 20 . . . cord-014516-r59usk02 1907 1 Small small JJ cord-014516-r59usk02 1907 2 breed breed NN cord-014516-r59usk02 1907 3 puppies puppy NNS cord-014516-r59usk02 1907 4 had have VBD cord-014516-r59usk02 1907 5 significantly significantly RB cord-014516-r59usk02 1907 6 higher high JJR cord-014516-r59usk02 1907 7 fecal fecal JJ cord-014516-r59usk02 1907 8 IgA IgA NNP cord-014516-r59usk02 1907 9 concentrations concentration NNS cord-014516-r59usk02 1907 10 than than IN cord-014516-r59usk02 1907 11 large large JJ cord-014516-r59usk02 1907 12 breed breed NN cord-014516-r59usk02 1907 13 puppies puppy NNS cord-014516-r59usk02 1907 14 ( ( -LRB- cord-014516-r59usk02 1907 15 6.8 6.8 CD cord-014516-r59usk02 1907 16 AE AE NNP cord-014516-r59usk02 1907 17 4.8 4.8 CD cord-014516-r59usk02 1907 18 lg lg NNP cord-014516-r59usk02 1907 19 / / SYM cord-014516-r59usk02 1907 20 g g NN cord-014516-r59usk02 1907 21 vs. vs. FW cord-014516-r59usk02 1907 22 5.0 5.0 CD cord-014516-r59usk02 1907 23 AE AE NNP cord-014516-r59usk02 1907 24 4.7 4.7 CD cord-014516-r59usk02 1907 25 lg lg NN cord-014516-r59usk02 1907 26 / / SYM cord-014516-r59usk02 1907 27 g g NN cord-014516-r59usk02 1907 28 ) ) -RRB- cord-014516-r59usk02 1907 29 . . . cord-014516-r59usk02 1908 1 No no DT cord-014516-r59usk02 1908 2 significant significant JJ cord-014516-r59usk02 1908 3 relationship relationship NN cord-014516-r59usk02 1908 4 between between IN cord-014516-r59usk02 1908 5 fecal fecal JJ cord-014516-r59usk02 1908 6 IgA IgA NNP cord-014516-r59usk02 1908 7 concentration concentration NN cord-014516-r59usk02 1908 8 and and CC cord-014516-r59usk02 1908 9 feces fece VBZ cord-014516-r59usk02 1908 10 quality quality NN cord-014516-r59usk02 1908 11 was be VBD cord-014516-r59usk02 1908 12 evidenced evidence VBN cord-014516-r59usk02 1909 1 ( ( -LRB- cord-014516-r59usk02 1909 2 p p NN cord-014516-r59usk02 1909 3 = = SYM cord-014516-r59usk02 1909 4 0.165 0.165 CD cord-014516-r59usk02 1909 5 ) ) -RRB- cord-014516-r59usk02 1909 6 . . . cord-014516-r59usk02 1910 1 This this DT cord-014516-r59usk02 1910 2 study study NN cord-014516-r59usk02 1910 3 suggests suggest VBZ cord-014516-r59usk02 1910 4 that that IN cord-014516-r59usk02 1910 5 fecal fecal JJ cord-014516-r59usk02 1910 6 IgA IgA NNP cord-014516-r59usk02 1910 7 concentration concentration NN cord-014516-r59usk02 1910 8 is be VBZ cord-014516-r59usk02 1910 9 a a DT cord-014516-r59usk02 1910 10 promising promising JJ cord-014516-r59usk02 1910 11 marker marker NN cord-014516-r59usk02 1910 12 for for IN cord-014516-r59usk02 1910 13 subclinical subclinical JJ cord-014516-r59usk02 1910 14 infection infection NN cord-014516-r59usk02 1910 15 by by IN cord-014516-r59usk02 1910 16 at at RB cord-014516-r59usk02 1910 17 least least RBS cord-014516-r59usk02 1910 18 one one CD cord-014516-r59usk02 1910 19 enteropathogen enteropathogen NN cord-014516-r59usk02 1910 20 and and CC cord-014516-r59usk02 1910 21 confirms confirm VBZ cord-014516-r59usk02 1910 22 that that IN cord-014516-r59usk02 1910 23 digestive digestive JJ cord-014516-r59usk02 1910 24 physiology physiology NN cord-014516-r59usk02 1910 25 varies vary VBZ cord-014516-r59usk02 1910 26 with with IN cord-014516-r59usk02 1910 27 the the DT cord-014516-r59usk02 1910 28 breed breed NN cord-014516-r59usk02 1910 29 size size NN cord-014516-r59usk02 1910 30 . . . cord-014516-r59usk02 1911 1 A a DT cord-014516-r59usk02 1911 2 link link NN cord-014516-r59usk02 1911 3 between between IN cord-014516-r59usk02 1911 4 lower low JJR cord-014516-r59usk02 1911 5 digestive digestive JJ cord-014516-r59usk02 1911 6 immunity immunity NN cord-014516-r59usk02 1911 7 and and CC cord-014516-r59usk02 1911 8 higher high JJR cord-014516-r59usk02 1911 9 susceptibility susceptibility NN cord-014516-r59usk02 1911 10 to to IN cord-014516-r59usk02 1911 11 enteropathogen enteropathogen NN cord-014516-r59usk02 1911 12 infection infection NN cord-014516-r59usk02 1911 13 needs need VBZ cord-014516-r59usk02 1911 14 further further JJ cord-014516-r59usk02 1911 15 investigation investigation NN cord-014516-r59usk02 1911 16 . . . cord-014516-r59usk02 1912 1 Conflicts conflict NNS cord-014516-r59usk02 1912 2 of of IN cord-014516-r59usk02 1912 3 interest interest NN cord-014516-r59usk02 1912 4 : : : cord-014516-r59usk02 1912 5 Financial financial JJ cord-014516-r59usk02 1912 6 support support NN cord-014516-r59usk02 1912 7 of of IN cord-014516-r59usk02 1912 8 Royal Royal NNP cord-014516-r59usk02 1912 9 Canin Canin NNP cord-014516-r59usk02 1912 10 . . . cord-014516-r59usk02 1913 1 Canine canine JJ cord-014516-r59usk02 1913 2 chronic chronic JJ cord-014516-r59usk02 1913 3 enteropathies enteropathy NNS cord-014516-r59usk02 1913 4 ( ( -LRB- cord-014516-r59usk02 1913 5 CCE CCE NNP cord-014516-r59usk02 1913 6 ) ) -RRB- cord-014516-r59usk02 1913 7 include include VBP cord-014516-r59usk02 1913 8 diet diet NN cord-014516-r59usk02 1913 9 - - HYPH cord-014516-r59usk02 1913 10 responsive responsive JJ cord-014516-r59usk02 1913 11 , , , cord-014516-r59usk02 1913 12 antibiotic antibiotic JJ cord-014516-r59usk02 1913 13 - - HYPH cord-014516-r59usk02 1913 14 responsive responsive JJ cord-014516-r59usk02 1913 15 , , , cord-014516-r59usk02 1913 16 and and CC cord-014516-r59usk02 1913 17 immunosuppressive immunosuppressive JJ cord-014516-r59usk02 1913 18 - - HYPH cord-014516-r59usk02 1913 19 responsive responsive JJ cord-014516-r59usk02 1913 20 enteropathies enteropathy NNS cord-014516-r59usk02 1913 21 ( ( -LRB- cord-014516-r59usk02 1913 22 IRE ire NN cord-014516-r59usk02 1913 23 ) ) -RRB- cord-014516-r59usk02 1913 24 . . . cord-014516-r59usk02 1914 1 This this DT cord-014516-r59usk02 1914 2 prospective prospective JJ cord-014516-r59usk02 1914 3 study study NN cord-014516-r59usk02 1914 4 was be VBD cord-014516-r59usk02 1914 5 designed design VBN cord-014516-r59usk02 1914 6 to to TO cord-014516-r59usk02 1914 7 evaluate evaluate VB cord-014516-r59usk02 1914 8 a a DT cord-014516-r59usk02 1914 9 commercial commercial JJ cord-014516-r59usk02 1914 10 hypoallergenic hypoallergenic JJ cord-014516-r59usk02 1914 11 dry dry JJ cord-014516-r59usk02 1914 12 diet diet NN cord-014516-r59usk02 1914 13 a a DT cord-014516-r59usk02 1914 14 containing contain VBG cord-014516-r59usk02 1914 15 oligopeptides oligopeptide NNS cord-014516-r59usk02 1914 16 as as IN cord-014516-r59usk02 1914 17 the the DT cord-014516-r59usk02 1914 18 only only JJ cord-014516-r59usk02 1914 19 protein protein NN cord-014516-r59usk02 1914 20 source source NN cord-014516-r59usk02 1914 21 for for IN cord-014516-r59usk02 1914 22 the the DT cord-014516-r59usk02 1914 23 management management NN cord-014516-r59usk02 1914 24 of of IN cord-014516-r59usk02 1914 25 dogs dog NNS cord-014516-r59usk02 1914 26 with with IN cord-014516-r59usk02 1914 27 IRE IRE NNP cord-014516-r59usk02 1914 28 and and CC cord-014516-r59usk02 1914 29 as as IN cord-014516-r59usk02 1914 30 an an DT cord-014516-r59usk02 1914 31 alternative alternative NN cord-014516-r59usk02 1914 32 to to IN cord-014516-r59usk02 1914 33 immunosuppressive immunosuppressive JJ cord-014516-r59usk02 1914 34 therapy therapy NN cord-014516-r59usk02 1914 35 over over IN cord-014516-r59usk02 1914 36 a a DT cord-014516-r59usk02 1914 37 10 10 CD cord-014516-r59usk02 1914 38 week week NN cord-014516-r59usk02 1914 39 period period NN cord-014516-r59usk02 1914 40 . . . cord-014516-r59usk02 1915 1 Nineteen nineteen CD cord-014516-r59usk02 1915 2 dogs dog NNS cord-014516-r59usk02 1915 3 across across IN cord-014516-r59usk02 1915 4 France France NNP cord-014516-r59usk02 1915 5 and and CC cord-014516-r59usk02 1915 6 Quebec Quebec NNP cord-014516-r59usk02 1915 7 entered enter VBD cord-014516-r59usk02 1915 8 the the DT cord-014516-r59usk02 1915 9 study study NN cord-014516-r59usk02 1915 10 . . . cord-014516-r59usk02 1916 1 Dogs dog NNS cord-014516-r59usk02 1916 2 with with IN cord-014516-r59usk02 1916 3 food food NN cord-014516-r59usk02 1916 4 or or CC cord-014516-r59usk02 1916 5 antibiotic antibiotic JJ cord-014516-r59usk02 1916 6 - - HYPH cord-014516-r59usk02 1916 7 responsive responsive JJ cord-014516-r59usk02 1916 8 chronic chronic NN cord-014516-r59usk02 1916 9 enteropathy enteropathy NNP cord-014516-r59usk02 1916 10 , , , cord-014516-r59usk02 1916 11 hypoproteinemia hypoproteinemia NNP cord-014516-r59usk02 1916 12 , , , cord-014516-r59usk02 1916 13 or or CC cord-014516-r59usk02 1916 14 treated treat VBN cord-014516-r59usk02 1916 15 with with IN cord-014516-r59usk02 1916 16 immunomodulating immunomodulating JJ cord-014516-r59usk02 1916 17 drugs drug NNS cord-014516-r59usk02 1916 18 were be VBD cord-014516-r59usk02 1916 19 excluded exclude VBN cord-014516-r59usk02 1916 20 from from IN cord-014516-r59usk02 1916 21 the the DT cord-014516-r59usk02 1916 22 study study NN cord-014516-r59usk02 1916 23 . . . cord-014516-r59usk02 1917 1 Dogs dog NNS cord-014516-r59usk02 1917 2 were be VBD cord-014516-r59usk02 1917 3 included include VBN cord-014516-r59usk02 1917 4 in in IN cord-014516-r59usk02 1917 5 the the DT cord-014516-r59usk02 1917 6 study study NN cord-014516-r59usk02 1917 7 after after IN cord-014516-r59usk02 1917 8 complete complete JJ cord-014516-r59usk02 1917 9 clinical clinical JJ cord-014516-r59usk02 1917 10 , , , cord-014516-r59usk02 1917 11 ultrasonographic ultrasonographic JJ cord-014516-r59usk02 1917 12 , , , cord-014516-r59usk02 1917 13 endoscopic endoscopic JJ cord-014516-r59usk02 1917 14 evaluation evaluation NN cord-014516-r59usk02 1917 15 and and CC cord-014516-r59usk02 1917 16 histopathological histopathological JJ cord-014516-r59usk02 1917 17 evaluation evaluation NN cord-014516-r59usk02 1917 18 of of IN cord-014516-r59usk02 1917 19 intestinal intestinal JJ cord-014516-r59usk02 1917 20 biopsies biopsy NNS cord-014516-r59usk02 1917 21 showing show VBG cord-014516-r59usk02 1917 22 signs sign NNS cord-014516-r59usk02 1917 23 of of IN cord-014516-r59usk02 1917 24 intestinal intestinal JJ cord-014516-r59usk02 1917 25 inflammation inflammation NN cord-014516-r59usk02 1917 26 . . . cord-014516-r59usk02 1918 1 The the DT cord-014516-r59usk02 1918 2 owners owner NNS cord-014516-r59usk02 1918 3 were be VBD cord-014516-r59usk02 1918 4 instructed instruct VBN cord-014516-r59usk02 1918 5 to to TO cord-014516-r59usk02 1918 6 feed feed VB cord-014516-r59usk02 1918 7 exclusively exclusively RB cord-014516-r59usk02 1918 8 the the DT cord-014516-r59usk02 1918 9 study study NN cord-014516-r59usk02 1918 10 diet diet NN cord-014516-r59usk02 1918 11 a a DT cord-014516-r59usk02 1918 12 . . . cord-014516-r59usk02 1919 1 Canine canine JJ cord-014516-r59usk02 1919 2 Inflammatory inflammatory JJ cord-014516-r59usk02 1919 3 Bowel Bowel NNP cord-014516-r59usk02 1919 4 Disease Disease NNP cord-014516-r59usk02 1919 5 Activity Activity NNP cord-014516-r59usk02 1919 6 Index Index NNP cord-014516-r59usk02 1919 7 ( ( -LRB- cord-014516-r59usk02 1919 8 CIBDAI CIBDAI NNP cord-014516-r59usk02 1919 9 ) ) -RRB- cord-014516-r59usk02 1919 10 scores score NNS cord-014516-r59usk02 1919 11 , , , cord-014516-r59usk02 1919 12 fecal fecal JJ cord-014516-r59usk02 1919 13 scores score NNS cord-014516-r59usk02 1919 14 as as IN cord-014516-r59usk02 1919 15 observed observe VBN cord-014516-r59usk02 1919 16 by by IN cord-014516-r59usk02 1919 17 the the DT cord-014516-r59usk02 1919 18 dog dog NN cord-014516-r59usk02 1919 19 - - HYPH cord-014516-r59usk02 1919 20 owners owner NNS cord-014516-r59usk02 1919 21 , , , cord-014516-r59usk02 1919 22 and and CC cord-014516-r59usk02 1919 23 body body NN cord-014516-r59usk02 1919 24 weight weight NN cord-014516-r59usk02 1919 25 were be VBD cord-014516-r59usk02 1919 26 evaluated evaluate VBN cord-014516-r59usk02 1919 27 at at IN cord-014516-r59usk02 1919 28 baseline baseline NN cord-014516-r59usk02 1919 29 , , , cord-014516-r59usk02 1919 30 2 2 CD cord-014516-r59usk02 1919 31 , , , cord-014516-r59usk02 1919 32 5 5 CD cord-014516-r59usk02 1919 33 and and CC cord-014516-r59usk02 1919 34 10 10 CD cord-014516-r59usk02 1919 35 weeks week NNS cord-014516-r59usk02 1919 36 after after IN cord-014516-r59usk02 1919 37 inclusion inclusion NN cord-014516-r59usk02 1919 38 . . . cord-014516-r59usk02 1920 1 Dietary dietary JJ cord-014516-r59usk02 1920 2 treatment treatment NN cord-014516-r59usk02 1920 3 was be VBD cord-014516-r59usk02 1920 4 regarded regard VBN cord-014516-r59usk02 1920 5 successful successful JJ cord-014516-r59usk02 1920 6 if if IN cord-014516-r59usk02 1920 7 the the DT cord-014516-r59usk02 1920 8 CIBDAI CIBDAI NNP cord-014516-r59usk02 1920 9 score score NN cord-014516-r59usk02 1920 10 was be VBD cord-014516-r59usk02 1920 11 reduced reduce VBN cord-014516-r59usk02 1920 12 by by IN cord-014516-r59usk02 1920 13 at at RB cord-014516-r59usk02 1920 14 least least RBS cord-014516-r59usk02 1920 15 75 75 CD cord-014516-r59usk02 1920 16 % % NN cord-014516-r59usk02 1920 17 . . . cord-014516-r59usk02 1921 1 The the DT cord-014516-r59usk02 1921 2 protocol protocol NN cord-014516-r59usk02 1921 3 has have VBZ cord-014516-r59usk02 1921 4 been be VBN cord-014516-r59usk02 1921 5 reviewed review VBN cord-014516-r59usk02 1921 6 and and CC cord-014516-r59usk02 1921 7 accepted accept VBN cord-014516-r59usk02 1921 8 by by IN cord-014516-r59usk02 1921 9 Royal Royal NNP cord-014516-r59usk02 1921 10 Canin Canin NNP cord-014516-r59usk02 1921 11 ethics ethic NNS cord-014516-r59usk02 1921 12 committee committee NN cord-014516-r59usk02 1921 13 and and CC cord-014516-r59usk02 1921 14 owners owner NNS cord-014516-r59usk02 1921 15 completed complete VBD cord-014516-r59usk02 1921 16 an an DT cord-014516-r59usk02 1921 17 informed informed JJ cord-014516-r59usk02 1921 18 consent consent NN cord-014516-r59usk02 1921 19 . . . cord-014516-r59usk02 1922 1 Results result NNS cord-014516-r59usk02 1922 2 are be VBP cord-014516-r59usk02 1922 3 presented present VBN cord-014516-r59usk02 1922 4 as as IN cord-014516-r59usk02 1922 5 meanAESD meanaesd FW cord-014516-r59usk02 1922 6 ( ( -LRB- cord-014516-r59usk02 1922 7 range range NN cord-014516-r59usk02 1922 8 ) ) -RRB- cord-014516-r59usk02 1922 9 . . . cord-014516-r59usk02 1923 1 Statistical statistical JJ cord-014516-r59usk02 1923 2 comparisons comparison NNS cord-014516-r59usk02 1923 3 were be VBD cord-014516-r59usk02 1923 4 performed perform VBN cord-014516-r59usk02 1923 5 with with IN cord-014516-r59usk02 1923 6 a a DT cord-014516-r59usk02 1923 7 Wilcoxon Wilcoxon NNP cord-014516-r59usk02 1923 8 test test NN cord-014516-r59usk02 1923 9 . . . cord-014516-r59usk02 1924 1 Thirteen thirteen CD cord-014516-r59usk02 1924 2 dogs dog NNS cord-014516-r59usk02 1924 3 ( ( -LRB- cord-014516-r59usk02 1924 4 7 7 CD cord-014516-r59usk02 1924 5 intact intact JJ cord-014516-r59usk02 1924 6 males male NNS cord-014516-r59usk02 1924 7 , , , cord-014516-r59usk02 1924 8 4 4 CD cord-014516-r59usk02 1924 9 neutered neuter VBN cord-014516-r59usk02 1924 10 and and CC cord-014516-r59usk02 1924 11 2 2 CD cord-014516-r59usk02 1924 12 intact intact JJ cord-014516-r59usk02 1924 13 females female NNS cord-014516-r59usk02 1924 14 ) ) -RRB- cord-014516-r59usk02 1924 15 completed complete VBD cord-014516-r59usk02 1924 16 the the DT cord-014516-r59usk02 1924 17 trial trial NN cord-014516-r59usk02 1924 18 . . . cord-014516-r59usk02 1925 1 Seven seven CD cord-014516-r59usk02 1925 2 dogs dog NNS cord-014516-r59usk02 1925 3 were be VBD cord-014516-r59usk02 1925 4 excluded exclude VBN cord-014516-r59usk02 1925 5 ( ( -LRB- cord-014516-r59usk02 1925 6 2 2 CD cord-014516-r59usk02 1925 7 diagnosed diagnose VBN cord-014516-r59usk02 1925 8 with with IN cord-014516-r59usk02 1925 9 Giardia Giardia NNP cord-014516-r59usk02 1925 10 , , , cord-014516-r59usk02 1925 11 4 4 CD cord-014516-r59usk02 1925 12 s s NN cord-014516-r59usk02 1925 13 with with IN cord-014516-r59usk02 1925 14 no no DT cord-014516-r59usk02 1925 15 histological histological JJ cord-014516-r59usk02 1925 16 evidence evidence NN cord-014516-r59usk02 1925 17 of of IN cord-014516-r59usk02 1925 18 inflammation inflammation NN cord-014516-r59usk02 1925 19 , , , cord-014516-r59usk02 1925 20 1 1 CD cord-014516-r59usk02 1925 21 with with IN cord-014516-r59usk02 1925 22 hypoadrenocorticism hypoadrenocorticism NNP cord-014516-r59usk02 1925 23 ) ) -RRB- cord-014516-r59usk02 1925 24 . . . cord-014516-r59usk02 1926 1 Mean mean JJ cord-014516-r59usk02 1926 2 age age NN cord-014516-r59usk02 1926 3 was be VBD cord-014516-r59usk02 1926 4 4.4 4.4 CD cord-014516-r59usk02 1926 5 years year NNS cord-014516-r59usk02 1926 6 AE AE NNP cord-014516-r59usk02 1926 7 3.01 3.01 CD cord-014516-r59usk02 1926 8 ( ( -LRB- cord-014516-r59usk02 1926 9 1.1 1.1 CD cord-014516-r59usk02 1926 10 -11.2 -11.2 CD cord-014516-r59usk02 1926 11 ) ) -RRB- cord-014516-r59usk02 1926 12 , , , cord-014516-r59usk02 1926 13 mean mean VB cord-014516-r59usk02 1926 14 body body NN cord-014516-r59usk02 1926 15 weight weight NN cord-014516-r59usk02 1926 16 16.2 16.2 CD cord-014516-r59usk02 1926 17 kg kg NNS cord-014516-r59usk02 1927 1 AE AE NNP cord-014516-r59usk02 1927 2 13.36 13.36 CD cord-014516-r59usk02 1927 3 ( ( -LRB- cord-014516-r59usk02 1927 4 2.5 2.5 CD cord-014516-r59usk02 1927 5 -43.0 -43.0 CD cord-014516-r59usk02 1927 6 ) ) -RRB- cord-014516-r59usk02 1927 7 . . . cord-014516-r59usk02 1928 1 CIBDAI CIBDAI NNP cord-014516-r59usk02 1928 2 score score NN cord-014516-r59usk02 1928 3 was be VBD cord-014516-r59usk02 1928 4 9.4 9.4 CD cord-014516-r59usk02 1928 5 AE AE NNP cord-014516-r59usk02 1928 6 3.43 3.43 CD cord-014516-r59usk02 1928 7 ( ( -LRB- cord-014516-r59usk02 1928 8 4 4 CD cord-014516-r59usk02 1928 9 - - SYM cord-014516-r59usk02 1928 10 16 16 CD cord-014516-r59usk02 1928 11 ) ) -RRB- cord-014516-r59usk02 1928 12 at at IN cord-014516-r59usk02 1928 13 inclusion inclusion NN cord-014516-r59usk02 1928 14 , , , cord-014516-r59usk02 1928 15 was be VBD cord-014516-r59usk02 1928 16 2.7 2.7 CD cord-014516-r59usk02 1928 17 AE AE NNP cord-014516-r59usk02 1928 18 1.84 1.84 CD cord-014516-r59usk02 1928 19 ( ( -LRB- cord-014516-r59usk02 1928 20 0 0 CD cord-014516-r59usk02 1928 21 - - SYM cord-014516-r59usk02 1928 22 6 6 CD cord-014516-r59usk02 1928 23 ) ) -RRB- cord-014516-r59usk02 1928 24 after after IN cord-014516-r59usk02 1928 25 5 5 CD cord-014516-r59usk02 1928 26 weeks week NNS cord-014516-r59usk02 1928 27 and and CC cord-014516-r59usk02 1928 28 was be VBD cord-014516-r59usk02 1928 29 1.5 1.5 CD cord-014516-r59usk02 1928 30 AE AE NNP cord-014516-r59usk02 1928 31 1.31(0 1.31(0 CD cord-014516-r59usk02 1928 32 - - SYM cord-014516-r59usk02 1928 33 3 3 CD cord-014516-r59usk02 1928 34 ) ) -RRB- cord-014516-r59usk02 1928 35 after after IN cord-014516-r59usk02 1928 36 10 10 CD cord-014516-r59usk02 1928 37 weeks week NNS cord-014516-r59usk02 1928 38 ( ( -LRB- cord-014516-r59usk02 1928 39 p p NN cord-014516-r59usk02 1928 40 = = SYM cord-014516-r59usk02 1928 41 0.0015 0.0015 CD cord-014516-r59usk02 1928 42 and and CC cord-014516-r59usk02 1928 43 p p NN cord-014516-r59usk02 1928 44 = = SYM cord-014516-r59usk02 1928 45 0.0022 0.0022 CD cord-014516-r59usk02 1928 46 vs vs IN cord-014516-r59usk02 1928 47 inclusion inclusion NN cord-014516-r59usk02 1928 48 , , , cord-014516-r59usk02 1928 49 respectively respectively RB cord-014516-r59usk02 1928 50 ) ) -RRB- cord-014516-r59usk02 1928 51 . . . cord-014516-r59usk02 1929 1 Fecal fecal JJ cord-014516-r59usk02 1929 2 scores score NNS cord-014516-r59usk02 1929 3 after after IN cord-014516-r59usk02 1929 4 5 5 CD cord-014516-r59usk02 1929 5 [ [ -LRB- cord-014516-r59usk02 1929 6 4.0 4.0 CD cord-014516-r59usk02 1929 7 AE AE NNP cord-014516-r59usk02 1929 8 0.58 0.58 CD cord-014516-r59usk02 1929 9 ( ( -LRB- cord-014516-r59usk02 1929 10 3 3 CD cord-014516-r59usk02 1929 11 - - SYM cord-014516-r59usk02 1929 12 5 5 CD cord-014516-r59usk02 1929 13 ) ) -RRB- cord-014516-r59usk02 1929 14 ] ] -RRB- cord-014516-r59usk02 1929 15 and and CC cord-014516-r59usk02 1929 16 10 10 CD cord-014516-r59usk02 1929 17 weeks week NNS cord-014516-r59usk02 1929 18 [ [ -LRB- cord-014516-r59usk02 1929 19 4.0 4.0 CD cord-014516-r59usk02 1929 20 AE AE NNP cord-014516-r59usk02 1929 21 0.60 0.60 CD cord-014516-r59usk02 1929 22 ( ( -LRB- cord-014516-r59usk02 1929 23 3 3 CD cord-014516-r59usk02 1929 24 - - SYM cord-014516-r59usk02 1929 25 5 5 CD cord-014516-r59usk02 1929 26 ) ) -RRB- cord-014516-r59usk02 1929 27 ] ] -RRB- cord-014516-r59usk02 1929 28 were be VBD cord-014516-r59usk02 1929 29 improved improve VBN cord-014516-r59usk02 1929 30 compared compare VBN cord-014516-r59usk02 1929 31 to to IN cord-014516-r59usk02 1929 32 inclusion inclusion NN cord-014516-r59usk02 1929 33 scores score NNS cord-014516-r59usk02 1929 34 1.9 1.9 CD cord-014516-r59usk02 1929 35 AE AE NNP cord-014516-r59usk02 1929 36 1.12 1.12 CD cord-014516-r59usk02 1929 37 ( ( -LRB- cord-014516-r59usk02 1929 38 1 1 CD cord-014516-r59usk02 1929 39 - - SYM cord-014516-r59usk02 1929 40 4 4 CD cord-014516-r59usk02 1929 41 ) ) -RRB- cord-014516-r59usk02 1929 42 ( ( -LRB- cord-014516-r59usk02 1929 43 p p NN cord-014516-r59usk02 1929 44 = = SYM cord-014516-r59usk02 1929 45 0.0033 0.0033 CD cord-014516-r59usk02 1929 46 and and CC cord-014516-r59usk02 1929 47 p p NN cord-014516-r59usk02 1929 48 = = SYM cord-014516-r59usk02 1929 49 0.0051 0.0051 CD cord-014516-r59usk02 1929 50 , , , cord-014516-r59usk02 1929 51 respectively respectively RB cord-014516-r59usk02 1929 52 ) ) -RRB- cord-014516-r59usk02 1929 53 . . . cord-014516-r59usk02 1930 1 The the DT cord-014516-r59usk02 1930 2 low low JJ cord-014516-r59usk02 1930 3 molecular molecular JJ cord-014516-r59usk02 1930 4 weight weight NN cord-014516-r59usk02 1930 5 poultry poultry NN cord-014516-r59usk02 1930 6 feather feather NN cord-014516-r59usk02 1930 7 hydrolyzed hydrolyze VBN cord-014516-r59usk02 1930 8 proteinbased proteinbase VBN cord-014516-r59usk02 1930 9 dry dry JJ cord-014516-r59usk02 1930 10 extruded extrude VBN cord-014516-r59usk02 1930 11 diet diet NN cord-014516-r59usk02 1931 1 a a DT cord-014516-r59usk02 1931 2 appears appear VBZ cord-014516-r59usk02 1931 3 to to TO cord-014516-r59usk02 1931 4 be be VB cord-014516-r59usk02 1931 5 effective effective JJ cord-014516-r59usk02 1931 6 in in IN cord-014516-r59usk02 1931 7 the the DT cord-014516-r59usk02 1931 8 management management NN cord-014516-r59usk02 1931 9 of of IN cord-014516-r59usk02 1931 10 idiopathic idiopathic JJ cord-014516-r59usk02 1931 11 IBD IBD NNP cord-014516-r59usk02 1931 12 without without IN cord-014516-r59usk02 1931 13 any any DT cord-014516-r59usk02 1931 14 concurrent concurrent JJ cord-014516-r59usk02 1931 15 immunosuppressive immunosuppressive JJ cord-014516-r59usk02 1931 16 drug drug NN cord-014516-r59usk02 1931 17 over over IN cord-014516-r59usk02 1931 18 the the DT cord-014516-r59usk02 1931 19 10 10 CD cord-014516-r59usk02 1931 20 week week NN cord-014516-r59usk02 1931 21 period period NN cord-014516-r59usk02 1931 22 of of IN cord-014516-r59usk02 1931 23 this this DT cord-014516-r59usk02 1931 24 pilot pilot NN cord-014516-r59usk02 1931 25 study study NN cord-014516-r59usk02 1931 26 . . . cord-014516-r59usk02 1932 1 These these DT cord-014516-r59usk02 1932 2 preliminary preliminary JJ cord-014516-r59usk02 1932 3 findings finding NNS cord-014516-r59usk02 1932 4 should should MD cord-014516-r59usk02 1932 5 be be VB cord-014516-r59usk02 1932 6 confirmed confirm VBN cord-014516-r59usk02 1932 7 by by IN cord-014516-r59usk02 1932 8 a a DT cord-014516-r59usk02 1932 9 prospective prospective NN cord-014516-r59usk02 1932 10 , , , cord-014516-r59usk02 1932 11 randomized randomized JJ cord-014516-r59usk02 1932 12 double double JJ cord-014516-r59usk02 1932 13 blind blind JJ cord-014516-r59usk02 1932 14 study study NN cord-014516-r59usk02 1932 15 . . . cord-014516-r59usk02 1933 1 Feline feline JJ cord-014516-r59usk02 1933 2 pancreatitis pancreatitis NN cord-014516-r59usk02 1933 3 is be VBZ cord-014516-r59usk02 1933 4 the the DT cord-014516-r59usk02 1933 5 most most RBS cord-014516-r59usk02 1933 6 common common JJ cord-014516-r59usk02 1933 7 exocrine exocrine JJ cord-014516-r59usk02 1933 8 pancreatic pancreatic JJ cord-014516-r59usk02 1933 9 disorder disorder NN cord-014516-r59usk02 1933 10 with with IN cord-014516-r59usk02 1933 11 varied varied JJ cord-014516-r59usk02 1933 12 mortality mortality NN cord-014516-r59usk02 1933 13 . . . cord-014516-r59usk02 1934 1 However however RB cord-014516-r59usk02 1934 2 , , , cord-014516-r59usk02 1934 3 there there EX cord-014516-r59usk02 1934 4 is be VBZ cord-014516-r59usk02 1934 5 no no DT cord-014516-r59usk02 1934 6 available available JJ cord-014516-r59usk02 1934 7 and and CC cord-014516-r59usk02 1934 8 reliable reliable JJ cord-014516-r59usk02 1934 9 method method NN cord-014516-r59usk02 1934 10 to to TO cord-014516-r59usk02 1934 11 evaluate evaluate VB cord-014516-r59usk02 1934 12 the the DT cord-014516-r59usk02 1934 13 severity severity NN cord-014516-r59usk02 1934 14 and and CC cord-014516-r59usk02 1934 15 prognosis prognosis NN cord-014516-r59usk02 1934 16 of of IN cord-014516-r59usk02 1934 17 the the DT cord-014516-r59usk02 1934 18 disease disease NN cord-014516-r59usk02 1934 19 . . . cord-014516-r59usk02 1935 1 Ninety ninety CD cord-014516-r59usk02 1935 2 - - HYPH cord-014516-r59usk02 1935 3 two two CD cord-014516-r59usk02 1935 4 cats cat NNS cord-014516-r59usk02 1935 5 diagnosed diagnose VBN cord-014516-r59usk02 1935 6 as as IN cord-014516-r59usk02 1935 7 pancreatitis pancreatitis NN cord-014516-r59usk02 1935 8 with with IN cord-014516-r59usk02 1935 9 acute acute JJ cord-014516-r59usk02 1935 10 onset onset NN cord-014516-r59usk02 1935 11 of of IN cord-014516-r59usk02 1935 12 compatible compatible JJ cord-014516-r59usk02 1935 13 clinical clinical JJ cord-014516-r59usk02 1935 14 signs sign NNS cord-014516-r59usk02 1935 15 and and CC cord-014516-r59usk02 1935 16 a a DT cord-014516-r59usk02 1935 17 positive positive JJ cord-014516-r59usk02 1935 18 SNAP snap NN cord-014516-r59usk02 1935 19 â â NN cord-014516-r59usk02 1935 20 fPL fpl NN cord-014516-r59usk02 1935 21 TM TM NNP cord-014516-r59usk02 1935 22 Test test NN cord-014516-r59usk02 1935 23 between between IN cord-014516-r59usk02 1935 24 October October NNP cord-014516-r59usk02 1935 25 2011 2011 CD cord-014516-r59usk02 1935 26 and and CC cord-014516-r59usk02 1935 27 September September NNP cord-014516-r59usk02 1935 28 2013 2013 CD cord-014516-r59usk02 1935 29 were be VBD cord-014516-r59usk02 1935 30 enrolled enrol VBN cord-014516-r59usk02 1935 31 in in IN cord-014516-r59usk02 1935 32 this this DT cord-014516-r59usk02 1935 33 study study NN cord-014516-r59usk02 1935 34 . . . cord-014516-r59usk02 1936 1 All all DT cord-014516-r59usk02 1936 2 Cats cat NNS cord-014516-r59usk02 1936 3 were be VBD cord-014516-r59usk02 1936 4 divided divide VBN cord-014516-r59usk02 1936 5 into into IN cord-014516-r59usk02 1936 6 survival survival NN cord-014516-r59usk02 1936 7 ( ( -LRB- cord-014516-r59usk02 1936 8 n n NN cord-014516-r59usk02 1936 9 = = SYM cord-014516-r59usk02 1936 10 48 48 CD cord-014516-r59usk02 1936 11 ) ) -RRB- cord-014516-r59usk02 1936 12 and and CC cord-014516-r59usk02 1936 13 nonsurvival nonsurvival NNP cord-014516-r59usk02 1936 14 ( ( -LRB- cord-014516-r59usk02 1936 15 n n NN cord-014516-r59usk02 1936 16 = = SYM cord-014516-r59usk02 1936 17 44 44 CD cord-014516-r59usk02 1936 18 ) ) -RRB- cord-014516-r59usk02 1936 19 groups group NNS cord-014516-r59usk02 1936 20 . . . cord-014516-r59usk02 1937 1 Fifty fifty CD cord-014516-r59usk02 1937 2 - - HYPH cord-014516-r59usk02 1937 3 two two CD cord-014516-r59usk02 1937 4 parameters parameter NNS cord-014516-r59usk02 1937 5 including include VBG cord-014516-r59usk02 1937 6 signalments signalment NNS cord-014516-r59usk02 1937 7 , , , cord-014516-r59usk02 1937 8 clinical clinical JJ cord-014516-r59usk02 1937 9 signs sign NNS cord-014516-r59usk02 1937 10 , , , cord-014516-r59usk02 1937 11 physical physical JJ cord-014516-r59usk02 1937 12 examinations examination NNS cord-014516-r59usk02 1937 13 , , , cord-014516-r59usk02 1937 14 clinicopathological clinicopathological JJ cord-014516-r59usk02 1937 15 examinations examination NNS cord-014516-r59usk02 1937 16 , , , cord-014516-r59usk02 1937 17 diagnostic diagnostic JJ cord-014516-r59usk02 1937 18 images image NNS cord-014516-r59usk02 1937 19 , , , cord-014516-r59usk02 1937 20 complications complication NNS cord-014516-r59usk02 1937 21 and and CC cord-014516-r59usk02 1937 22 concurrent concurrent JJ cord-014516-r59usk02 1937 23 diseases disease NNS cord-014516-r59usk02 1937 24 were be VBD cord-014516-r59usk02 1937 25 analyzed analyze VBN cord-014516-r59usk02 1937 26 and and CC cord-014516-r59usk02 1937 27 compared compare VBN cord-014516-r59usk02 1937 28 between between IN cord-014516-r59usk02 1937 29 the the DT cord-014516-r59usk02 1937 30 two two CD cord-014516-r59usk02 1937 31 groups group NNS cord-014516-r59usk02 1937 32 . . . cord-014516-r59usk02 1938 1 Parameters parameter NNS cord-014516-r59usk02 1938 2 with with IN cord-014516-r59usk02 1938 3 P p NN cord-014516-r59usk02 1938 4 ≤ ≤ NN cord-014516-r59usk02 1938 5 0.05 0.05 CD cord-014516-r59usk02 1938 6 were be VBD cord-014516-r59usk02 1938 7 considered consider VBN cord-014516-r59usk02 1938 8 for for IN cord-014516-r59usk02 1938 9 further further JJ cord-014516-r59usk02 1938 10 analyses analysis NNS cord-014516-r59usk02 1938 11 . . . cord-014516-r59usk02 1939 1 The the DT cord-014516-r59usk02 1939 2 mortality mortality NN cord-014516-r59usk02 1939 3 in in IN cord-014516-r59usk02 1939 4 this this DT cord-014516-r59usk02 1939 5 study study NN cord-014516-r59usk02 1939 6 was be VBD cord-014516-r59usk02 1939 7 47.8 47.8 CD cord-014516-r59usk02 1939 8 % % NN cord-014516-r59usk02 1939 9 . . . cord-014516-r59usk02 1940 1 Hematocrit hematocrit NN cord-014516-r59usk02 1940 2 , , , cord-014516-r59usk02 1940 3 albumin albumin NN cord-014516-r59usk02 1940 4 , , , cord-014516-r59usk02 1940 5 BUN bun NN cord-014516-r59usk02 1940 6 , , , cord-014516-r59usk02 1940 7 creatinine creatinine NN cord-014516-r59usk02 1940 8 , , , cord-014516-r59usk02 1940 9 total total JJ cord-014516-r59usk02 1940 10 bilirubin bilirubin NN cord-014516-r59usk02 1940 11 , , , cord-014516-r59usk02 1940 12 calcium calcium NN cord-014516-r59usk02 1940 13 , , , cord-014516-r59usk02 1940 14 phosphorous phosphorous NN cord-014516-r59usk02 1940 15 , , , cord-014516-r59usk02 1940 16 body body NN cord-014516-r59usk02 1940 17 temperature temperature NN cord-014516-r59usk02 1940 18 , , , cord-014516-r59usk02 1940 19 systolic systolic JJ cord-014516-r59usk02 1940 20 blood blood NN cord-014516-r59usk02 1940 21 pressure pressure NN cord-014516-r59usk02 1940 22 , , , cord-014516-r59usk02 1940 23 the the DT cord-014516-r59usk02 1940 24 body body NN cord-014516-r59usk02 1940 25 cavity cavity NN cord-014516-r59usk02 1940 26 fluids fluid NNS cord-014516-r59usk02 1940 27 , , , cord-014516-r59usk02 1940 28 complications complication NNS cord-014516-r59usk02 1940 29 , , , cord-014516-r59usk02 1940 30 e.g. e.g. DT cord-014516-r59usk02 1940 31 systemic systemic JJ cord-014516-r59usk02 1940 32 inflammatory inflammatory JJ cord-014516-r59usk02 1940 33 response response NN cord-014516-r59usk02 1940 34 syndrome syndrome NN cord-014516-r59usk02 1940 35 ( ( -LRB- cord-014516-r59usk02 1940 36 SIRS sirs UH cord-014516-r59usk02 1940 37 ) ) -RRB- cord-014516-r59usk02 1940 38 and and CC cord-014516-r59usk02 1940 39 acute acute JJ cord-014516-r59usk02 1940 40 renal renal JJ cord-014516-r59usk02 1940 41 failure failure NN cord-014516-r59usk02 1940 42 ( ( -LRB- cord-014516-r59usk02 1940 43 ARF ARF NNP cord-014516-r59usk02 1940 44 ) ) -RRB- cord-014516-r59usk02 1940 45 were be VBD cord-014516-r59usk02 1940 46 found find VBN cord-014516-r59usk02 1940 47 to to TO cord-014516-r59usk02 1940 48 be be VB cord-014516-r59usk02 1940 49 significantly significantly RB cord-014516-r59usk02 1940 50 associated associate VBN cord-014516-r59usk02 1940 51 with with IN cord-014516-r59usk02 1940 52 disease disease NN cord-014516-r59usk02 1940 53 severity severity NN cord-014516-r59usk02 1940 54 and and CC cord-014516-r59usk02 1940 55 prognosis prognosis NN cord-014516-r59usk02 1940 56 , , , cord-014516-r59usk02 1940 57 and and CC cord-014516-r59usk02 1940 58 were be VBD cord-014516-r59usk02 1940 59 selected select VBN cord-014516-r59usk02 1940 60 for for IN cord-014516-r59usk02 1940 61 constructing construct VBG cord-014516-r59usk02 1940 62 the the DT cord-014516-r59usk02 1940 63 scores score NNS cord-014516-r59usk02 1940 64 . . . cord-014516-r59usk02 1941 1 Continuous continuous JJ cord-014516-r59usk02 1941 2 variables variable NNS cord-014516-r59usk02 1941 3 outside outside IN cord-014516-r59usk02 1941 4 the the DT cord-014516-r59usk02 1941 5 reference reference NN cord-014516-r59usk02 1941 6 interval interval NN cord-014516-r59usk02 1941 7 were be VBD cord-014516-r59usk02 1941 8 separated separate VBN cord-014516-r59usk02 1941 9 into into IN cord-014516-r59usk02 1941 10 quartiles quartile NNS cord-014516-r59usk02 1941 11 to to TO cord-014516-r59usk02 1941 12 yield yield VB cord-014516-r59usk02 1941 13 quartile quartile NN cord-014516-r59usk02 1941 14 - - HYPH cord-014516-r59usk02 1941 15 specific specific JJ cord-014516-r59usk02 1941 16 odds odd NNS cord-014516-r59usk02 1941 17 ratios ratio NNS cord-014516-r59usk02 1941 18 ( ( -LRB- cord-014516-r59usk02 1941 19 ORs or NNS cord-014516-r59usk02 1941 20 ) ) -RRB- cord-014516-r59usk02 1941 21 for for IN cord-014516-r59usk02 1941 22 survival survival NN cord-014516-r59usk02 1941 23 . . . cord-014516-r59usk02 1942 1 Based base VBN cord-014516-r59usk02 1942 2 on on IN cord-014516-r59usk02 1942 3 the the DT cord-014516-r59usk02 1942 4 integer integer NN cord-014516-r59usk02 1942 5 value value NN cord-014516-r59usk02 1942 6 of of IN cord-014516-r59usk02 1942 7 the the DT cord-014516-r59usk02 1942 8 OR OR NNP cord-014516-r59usk02 1942 9 , , , cord-014516-r59usk02 1942 10 the the DT cord-014516-r59usk02 1942 11 scoring scoring NN cord-014516-r59usk02 1942 12 system system NN cord-014516-r59usk02 1942 13 was be VBD cord-014516-r59usk02 1942 14 then then RB cord-014516-r59usk02 1942 15 developed develop VBN cord-014516-r59usk02 1942 16 by by IN cord-014516-r59usk02 1942 17 incorporating incorporate VBG cord-014516-r59usk02 1942 18 weighting weighting NN cord-014516-r59usk02 1942 19 factors factor NNS cord-014516-r59usk02 1942 20 assigned assign VBN cord-014516-r59usk02 1942 21 to to IN cord-014516-r59usk02 1942 22 each each DT cord-014516-r59usk02 1942 23 quartile quartile NN cord-014516-r59usk02 1942 24 . . . cord-014516-r59usk02 1943 1 A a DT cord-014516-r59usk02 1943 2 predictive predictive JJ cord-014516-r59usk02 1943 3 total total JJ cord-014516-r59usk02 1943 4 score score NN cord-014516-r59usk02 1943 5 was be VBD cord-014516-r59usk02 1943 6 calculated calculate VBN cord-014516-r59usk02 1943 7 for for IN cord-014516-r59usk02 1943 8 each each DT cord-014516-r59usk02 1943 9 cat cat NN cord-014516-r59usk02 1943 10 by by IN cord-014516-r59usk02 1943 11 summing sum VBG cord-014516-r59usk02 1943 12 all all DT cord-014516-r59usk02 1943 13 weighting weighting NN cord-014516-r59usk02 1943 14 factors factor NNS cord-014516-r59usk02 1943 15 . . . cord-014516-r59usk02 1944 1 The the DT cord-014516-r59usk02 1944 2 total total JJ cord-014516-r59usk02 1944 3 scores score NNS cord-014516-r59usk02 1944 4 of of IN cord-014516-r59usk02 1944 5 each each DT cord-014516-r59usk02 1944 6 cat cat NN cord-014516-r59usk02 1944 7 ranged range VBD cord-014516-r59usk02 1944 8 from from IN cord-014516-r59usk02 1944 9 12 12 CD cord-014516-r59usk02 1944 10 to to IN cord-014516-r59usk02 1944 11 83 83 CD cord-014516-r59usk02 1944 12 . . . cord-014516-r59usk02 1945 1 The the DT cord-014516-r59usk02 1945 2 severity severity NN cord-014516-r59usk02 1945 3 scores score NNS cord-014516-r59usk02 1945 4 in in IN cord-014516-r59usk02 1945 5 this this DT cord-014516-r59usk02 1945 6 study study NN cord-014516-r59usk02 1945 7 achieved achieve VBD cord-014516-r59usk02 1945 8 an an DT cord-014516-r59usk02 1945 9 area area NN cord-014516-r59usk02 1945 10 under under IN cord-014516-r59usk02 1945 11 receiver receiver NN cord-014516-r59usk02 1945 12 operating operating NN cord-014516-r59usk02 1945 13 characteristic characteristic NN cord-014516-r59usk02 1945 14 ( ( -LRB- cord-014516-r59usk02 1945 15 AUROC AUROC NNP cord-014516-r59usk02 1945 16 ) ) -RRB- cord-014516-r59usk02 1945 17 of of IN cord-014516-r59usk02 1945 18 0.88 0.88 CD cord-014516-r59usk02 1945 19 . . . cord-014516-r59usk02 1946 1 The the DT cord-014516-r59usk02 1946 2 optimal optimal JJ cord-014516-r59usk02 1946 3 cut cut NN cord-014516-r59usk02 1946 4 - - HYPH cord-014516-r59usk02 1946 5 off off RP cord-014516-r59usk02 1946 6 point point NN cord-014516-r59usk02 1946 7 for for IN cord-014516-r59usk02 1946 8 discriminating discriminate VBG cord-014516-r59usk02 1946 9 outcome outcome NN cord-014516-r59usk02 1946 10 was be VBD cord-014516-r59usk02 1946 11 32.5 32.5 CD cord-014516-r59usk02 1946 12 with with IN cord-014516-r59usk02 1946 13 the the DT cord-014516-r59usk02 1946 14 sensitivity sensitivity NN cord-014516-r59usk02 1946 15 of of IN cord-014516-r59usk02 1946 16 89.6 89.6 CD cord-014516-r59usk02 1946 17 % % NN cord-014516-r59usk02 1946 18 and and CC cord-014516-r59usk02 1946 19 specificity specificity NN cord-014516-r59usk02 1946 20 of of IN cord-014516-r59usk02 1946 21 77.3 77.3 CD cord-014516-r59usk02 1946 22 % % NN cord-014516-r59usk02 1946 23 , , , cord-014516-r59usk02 1946 24 respectively respectively RB cord-014516-r59usk02 1946 25 . . . cord-014516-r59usk02 1947 1 The the DT cord-014516-r59usk02 1947 2 mortality mortality NN cord-014516-r59usk02 1947 3 was be VBD cord-014516-r59usk02 1947 4 87.2 87.2 CD cord-014516-r59usk02 1947 5 % % NN cord-014516-r59usk02 1947 6 with with IN cord-014516-r59usk02 1947 7 a a DT cord-014516-r59usk02 1947 8 score score NN cord-014516-r59usk02 1947 9 ≥ ≥ CD cord-014516-r59usk02 1947 10 33 33 CD cord-014516-r59usk02 1947 11 , , , cord-014516-r59usk02 1947 12 whereas whereas IN cord-014516-r59usk02 1947 13 18.9 18.9 CD cord-014516-r59usk02 1947 14 % % NN cord-014516-r59usk02 1947 15 with with IN cord-014516-r59usk02 1947 16 a a DT cord-014516-r59usk02 1947 17 score score NN cord-014516-r59usk02 1947 18 ≤ ≤ NNP cord-014516-r59usk02 1947 19 32 32 CD cord-014516-r59usk02 1947 20 . . . cord-014516-r59usk02 1948 1 There there EX cord-014516-r59usk02 1948 2 was be VBD cord-014516-r59usk02 1948 3 significant significant JJ cord-014516-r59usk02 1948 4 difference difference NN cord-014516-r59usk02 1948 5 ( ( -LRB- cord-014516-r59usk02 1948 6 P p NN cord-014516-r59usk02 1948 7 < < XX cord-014516-r59usk02 1948 8 0.001 0.001 CD cord-014516-r59usk02 1948 9 ) ) -RRB- cord-014516-r59usk02 1948 10 between between IN cord-014516-r59usk02 1948 11 the the DT cord-014516-r59usk02 1948 12 two two CD cord-014516-r59usk02 1948 13 groups group NNS cord-014516-r59usk02 1948 14 of of IN cord-014516-r59usk02 1948 15 the the DT cord-014516-r59usk02 1948 16 cut cut VB cord-014516-r59usk02 1948 17 - - HYPH cord-014516-r59usk02 1948 18 off off RP cord-014516-r59usk02 1948 19 point point NN cord-014516-r59usk02 1948 20 . . . cord-014516-r59usk02 1949 1 Furthermore furthermore RB cord-014516-r59usk02 1949 2 , , , cord-014516-r59usk02 1949 3 the the DT cord-014516-r59usk02 1949 4 mortality mortality NN cord-014516-r59usk02 1949 5 reached reach VBD cord-014516-r59usk02 1949 6 to to IN cord-014516-r59usk02 1949 7 100 100 CD cord-014516-r59usk02 1949 8 % % NN cord-014516-r59usk02 1949 9 when when WRB cord-014516-r59usk02 1949 10 the the DT cord-014516-r59usk02 1949 11 score score NN cord-014516-r59usk02 1949 12 more more JJR cord-014516-r59usk02 1949 13 than than IN cord-014516-r59usk02 1949 14 56 56 CD cord-014516-r59usk02 1949 15 . . . cord-014516-r59usk02 1950 1 The the DT cord-014516-r59usk02 1950 2 severity severity NN cord-014516-r59usk02 1950 3 scoring score VBG cord-014516-r59usk02 1950 4 system system NN cord-014516-r59usk02 1950 5 of of IN cord-014516-r59usk02 1950 6 this this DT cord-014516-r59usk02 1950 7 study study NN cord-014516-r59usk02 1950 8 provides provide VBZ cord-014516-r59usk02 1950 9 a a DT cord-014516-r59usk02 1950 10 reliable reliable JJ cord-014516-r59usk02 1950 11 and and CC cord-014516-r59usk02 1950 12 clinical clinical JJ cord-014516-r59usk02 1950 13 applicable applicable JJ cord-014516-r59usk02 1950 14 method method NN cord-014516-r59usk02 1950 15 to to TO cord-014516-r59usk02 1950 16 predict predict VB cord-014516-r59usk02 1950 17 clinical clinical JJ cord-014516-r59usk02 1950 18 outcome outcome NN cord-014516-r59usk02 1950 19 in in IN cord-014516-r59usk02 1950 20 cats cat NNS cord-014516-r59usk02 1950 21 with with IN cord-014516-r59usk02 1950 22 pancreatitis pancreatitis NN cord-014516-r59usk02 1950 23 . . . cord-014516-r59usk02 1951 1 No no DT cord-014516-r59usk02 1951 2 conflicts conflict NNS cord-014516-r59usk02 1951 3 of of IN cord-014516-r59usk02 1951 4 interest interest NN cord-014516-r59usk02 1951 5 reported report VBN cord-014516-r59usk02 1951 6 . . . cord-014516-r59usk02 1952 1 Convincing convincing JJ cord-014516-r59usk02 1952 2 evidence evidence NN cord-014516-r59usk02 1952 3 for for IN cord-014516-r59usk02 1952 4 the the DT cord-014516-r59usk02 1952 5 role role NN cord-014516-r59usk02 1952 6 of of IN cord-014516-r59usk02 1952 7 Clostridium Clostridium NNP cord-014516-r59usk02 1952 8 ( ( -LRB- cord-014516-r59usk02 1952 9 C. C. NNP cord-014516-r59usk02 1952 10 ) ) -RRB- cord-014516-r59usk02 1952 11 perfringens perfringen VBZ cord-014516-r59usk02 1952 12 as as IN cord-014516-r59usk02 1952 13 a a DT cord-014516-r59usk02 1952 14 primary primary JJ cord-014516-r59usk02 1952 15 pathogen pathogen NN cord-014516-r59usk02 1952 16 in in IN cord-014516-r59usk02 1952 17 acute acute JJ cord-014516-r59usk02 1952 18 haemorrhagic haemorrhagic JJ cord-014516-r59usk02 1952 19 diarrhoea diarrhoea NN cord-014516-r59usk02 1952 20 syndrome syndrome NN cord-014516-r59usk02 1952 21 ( ( -LRB- cord-014516-r59usk02 1952 22 AHDS AHDS NNP cord-014516-r59usk02 1952 23 ) ) -RRB- cord-014516-r59usk02 1952 24 in in IN cord-014516-r59usk02 1952 25 dogs dog NNS cord-014516-r59usk02 1952 26 was be VBD cord-014516-r59usk02 1952 27 recently recently RB cord-014516-r59usk02 1952 28 found find VBN cord-014516-r59usk02 1952 29 . . . cord-014516-r59usk02 1953 1 It -PRON- PRP cord-014516-r59usk02 1953 2 is be VBZ cord-014516-r59usk02 1953 3 suspected suspect VBN cord-014516-r59usk02 1953 4 that that IN cord-014516-r59usk02 1953 5 clostridial clostridial JJ cord-014516-r59usk02 1953 6 toxins toxin NNS cord-014516-r59usk02 1953 7 , , , cord-014516-r59usk02 1953 8 especially especially RB cord-014516-r59usk02 1953 9 C. C. NNP cord-014516-r59usk02 1953 10 perfringens perfringens NN cord-014516-r59usk02 1953 11 enterotoxin enterotoxin NNP cord-014516-r59usk02 1953 12 , , , cord-014516-r59usk02 1953 13 play play VBP cord-014516-r59usk02 1953 14 a a DT cord-014516-r59usk02 1953 15 relevant relevant JJ cord-014516-r59usk02 1953 16 role role NN cord-014516-r59usk02 1953 17 in in IN cord-014516-r59usk02 1953 18 the the DT cord-014516-r59usk02 1953 19 disease disease NN cord-014516-r59usk02 1953 20 process process NN cord-014516-r59usk02 1953 21 . . . cord-014516-r59usk02 1954 1 However however RB cord-014516-r59usk02 1954 2 , , , cord-014516-r59usk02 1954 3 to to IN cord-014516-r59usk02 1954 4 date date NN cord-014516-r59usk02 1954 5 enterotoxigenic enterotoxigenic NNP cord-014516-r59usk02 1954 6 C. C. NNP cord-014516-r59usk02 1954 7 perfringens perfringen VBZ cord-014516-r59usk02 1954 8 strains strain NNS cord-014516-r59usk02 1954 9 have have VBP cord-014516-r59usk02 1954 10 only only RB cord-014516-r59usk02 1954 11 been be VBN cord-014516-r59usk02 1954 12 described describe VBN cord-014516-r59usk02 1954 13 in in IN cord-014516-r59usk02 1954 14 single single JJ cord-014516-r59usk02 1954 15 case case NN cord-014516-r59usk02 1954 16 reports report NNS cord-014516-r59usk02 1954 17 . . . cord-014516-r59usk02 1955 1 Thus thus RB cord-014516-r59usk02 1955 2 , , , cord-014516-r59usk02 1955 3 the the DT cord-014516-r59usk02 1955 4 aim aim NN cord-014516-r59usk02 1955 5 of of IN cord-014516-r59usk02 1955 6 this this DT cord-014516-r59usk02 1955 7 study study NN cord-014516-r59usk02 1955 8 was be VBD cord-014516-r59usk02 1955 9 to to TO cord-014516-r59usk02 1955 10 indentify indentify VB cord-014516-r59usk02 1955 11 the the DT cord-014516-r59usk02 1955 12 specific specific JJ cord-014516-r59usk02 1955 13 C. C. NNP cord-014516-r59usk02 1955 14 perfringens perfringens NN cord-014516-r59usk02 1955 15 genotype genotype NN cord-014516-r59usk02 1955 16 involved involve VBN cord-014516-r59usk02 1955 17 in in IN cord-014516-r59usk02 1955 18 ADHS ADHS NNP cord-014516-r59usk02 1955 19 . . . cord-014516-r59usk02 1956 1 Small small JJ cord-014516-r59usk02 1956 2 intestinal intestinal JJ cord-014516-r59usk02 1956 3 biopsies biopsy NNS cord-014516-r59usk02 1956 4 were be VBD cord-014516-r59usk02 1956 5 collected collect VBN cord-014516-r59usk02 1956 6 with with IN cord-014516-r59usk02 1956 7 a a DT cord-014516-r59usk02 1956 8 sterile sterile JJ cord-014516-r59usk02 1956 9 single single JJ cord-014516-r59usk02 1956 10 - - HYPH cord-014516-r59usk02 1956 11 use use NN cord-014516-r59usk02 1956 12 biopsy biopsy NN cord-014516-r59usk02 1956 13 forceps forceps NNS cord-014516-r59usk02 1956 14 from from IN cord-014516-r59usk02 1956 15 ten ten CD cord-014516-r59usk02 1956 16 dogs dog NNS cord-014516-r59usk02 1956 17 with with IN cord-014516-r59usk02 1956 18 AHDS AHDS NNP cord-014516-r59usk02 1956 19 and and CC cord-014516-r59usk02 1956 20 immediately immediately RB cord-014516-r59usk02 1956 21 cultured culture VBD cord-014516-r59usk02 1956 22 . . . cord-014516-r59usk02 1957 1 In in IN cord-014516-r59usk02 1957 2 8/10 8/10 CD cord-014516-r59usk02 1957 3 dogs dog NNS cord-014516-r59usk02 1957 4 , , , cord-014516-r59usk02 1957 5 clostridial clostridial JJ cord-014516-r59usk02 1957 6 strains strain NNS cord-014516-r59usk02 1957 7 were be VBD cord-014516-r59usk02 1957 8 isolated isolate VBN cord-014516-r59usk02 1957 9 and and CC cord-014516-r59usk02 1957 10 identified identify VBN cord-014516-r59usk02 1957 11 as as IN cord-014516-r59usk02 1957 12 C. C. NNP cord-014516-r59usk02 1957 13 perfringens perfringen NNS cord-014516-r59usk02 1957 14 by by IN cord-014516-r59usk02 1957 15 mass mass NN cord-014516-r59usk02 1957 16 spectrometry spectrometry NN cord-014516-r59usk02 1957 17 using use VBG cord-014516-r59usk02 1957 18 MALDI MALDI NNP cord-014516-r59usk02 1957 19 - - HYPH cord-014516-r59usk02 1957 20 TOF TOF NNP cord-014516-r59usk02 1957 21 MS MS NNP cord-014516-r59usk02 1957 22 . . . cord-014516-r59usk02 1958 1 C. C. NNP cord-014516-r59usk02 1958 2 perfringens perfringen VBZ cord-014516-r59usk02 1958 3 colonies colony NNS cord-014516-r59usk02 1958 4 from from IN cord-014516-r59usk02 1958 5 each each DT cord-014516-r59usk02 1958 6 dog dog NN cord-014516-r59usk02 1958 7 were be VBD cord-014516-r59usk02 1958 8 submitted submit VBN cord-014516-r59usk02 1958 9 for for IN cord-014516-r59usk02 1958 10 specific specific JJ cord-014516-r59usk02 1958 11 detection detection NN cord-014516-r59usk02 1958 12 of of IN cord-014516-r59usk02 1958 13 the the DT cord-014516-r59usk02 1958 14 four four CD cord-014516-r59usk02 1958 15 major major JJ cord-014516-r59usk02 1958 16 toxin toxin NN cord-014516-r59usk02 1958 17 genes gene NNS cord-014516-r59usk02 1958 18 ( ( -LRB- cord-014516-r59usk02 1958 19 alpha alpha NN cord-014516-r59usk02 1958 20 , , , cord-014516-r59usk02 1958 21 beta beta NN cord-014516-r59usk02 1958 22 , , , cord-014516-r59usk02 1958 23 epsilon epsilon NN cord-014516-r59usk02 1958 24 , , , cord-014516-r59usk02 1958 25 and and CC cord-014516-r59usk02 1958 26 iota iota NN cord-014516-r59usk02 1958 27 ) ) -RRB- cord-014516-r59usk02 1958 28 , , , cord-014516-r59usk02 1958 29 the the DT cord-014516-r59usk02 1958 30 enterotoxin enterotoxin NNP cord-014516-r59usk02 1958 31 gene gene NN cord-014516-r59usk02 1958 32 , , , cord-014516-r59usk02 1958 33 and and CC cord-014516-r59usk02 1958 34 the the DT cord-014516-r59usk02 1958 35 beta2 beta2 NN cord-014516-r59usk02 1958 36 toxin toxin NN cord-014516-r59usk02 1958 37 by by IN cord-014516-r59usk02 1958 38 multiplex multiplex NN cord-014516-r59usk02 1958 39 PCR pcr NN cord-014516-r59usk02 1958 40 . . . cord-014516-r59usk02 1959 1 Every every DT cord-014516-r59usk02 1959 2 clostridial clostridial JJ cord-014516-r59usk02 1959 3 isolate isolate NN cord-014516-r59usk02 1959 4 was be VBD cord-014516-r59usk02 1959 5 typed type VBN cord-014516-r59usk02 1959 6 as as IN cord-014516-r59usk02 1959 7 C. C. NNP cord-014516-r59usk02 1959 8 perfringens perfringens NN cord-014516-r59usk02 1959 9 type type NN cord-014516-r59usk02 1959 10 A a NN cord-014516-r59usk02 1959 11 based base VBN cord-014516-r59usk02 1959 12 on on IN cord-014516-r59usk02 1959 13 the the DT cord-014516-r59usk02 1959 14 detection detection NN cord-014516-r59usk02 1959 15 of of IN cord-014516-r59usk02 1959 16 the the DT cord-014516-r59usk02 1959 17 alpha alpha NN cord-014516-r59usk02 1959 18 toxin toxin NN cord-014516-r59usk02 1959 19 encoding encoding NN cord-014516-r59usk02 1959 20 gene gene NN cord-014516-r59usk02 1959 21 . . . cord-014516-r59usk02 1960 1 In in IN cord-014516-r59usk02 1960 2 5/8 5/8 CD cord-014516-r59usk02 1960 3 isolates isolate NNS cord-014516-r59usk02 1960 4 , , , cord-014516-r59usk02 1960 5 additionally additionally RB cord-014516-r59usk02 1960 6 the the DT cord-014516-r59usk02 1960 7 beta2 beta2 NN cord-014516-r59usk02 1960 8 toxin toxin NN cord-014516-r59usk02 1960 9 gene gene NN cord-014516-r59usk02 1960 10 was be VBD cord-014516-r59usk02 1960 11 identified identify VBN cord-014516-r59usk02 1960 12 , , , cord-014516-r59usk02 1960 13 however however RB cord-014516-r59usk02 1960 14 , , , cord-014516-r59usk02 1960 15 none none NN cord-014516-r59usk02 1960 16 of of IN cord-014516-r59usk02 1960 17 clostridial clostridial JJ cord-014516-r59usk02 1960 18 strains strain NNS cord-014516-r59usk02 1960 19 encoded encode VBN cord-014516-r59usk02 1960 20 for for IN cord-014516-r59usk02 1960 21 the the DT cord-014516-r59usk02 1960 22 C. C. NNP cord-014516-r59usk02 1960 23 perfringens perfringens NN cord-014516-r59usk02 1960 24 enterotoxin enterotoxin NN cord-014516-r59usk02 1960 25 gene gene NN cord-014516-r59usk02 1960 26 . . . cord-014516-r59usk02 1961 1 The the DT cord-014516-r59usk02 1961 2 results result NNS cord-014516-r59usk02 1961 3 of of IN cord-014516-r59usk02 1961 4 this this DT cord-014516-r59usk02 1961 5 study study NN cord-014516-r59usk02 1961 6 suggest suggest VBP cord-014516-r59usk02 1961 7 that that IN cord-014516-r59usk02 1961 8 C. C. NNP cord-014516-r59usk02 1961 9 perfringens perfringens NN cord-014516-r59usk02 1961 10 type type NN cord-014516-r59usk02 1961 11 A a NN cord-014516-r59usk02 1961 12 is be VBZ cord-014516-r59usk02 1961 13 the the DT cord-014516-r59usk02 1961 14 most most RBS cord-014516-r59usk02 1961 15 important important JJ cord-014516-r59usk02 1961 16 C. C. NNP cord-014516-r59usk02 1961 17 perfingens perfingens NNP cord-014516-r59usk02 1961 18 genotype genotype NN cord-014516-r59usk02 1961 19 involved involve VBN cord-014516-r59usk02 1961 20 in in IN cord-014516-r59usk02 1961 21 the the DT cord-014516-r59usk02 1961 22 disease disease NN cord-014516-r59usk02 1961 23 process process NN cord-014516-r59usk02 1961 24 of of IN cord-014516-r59usk02 1961 25 dogs dog NNS cord-014516-r59usk02 1961 26 with with IN cord-014516-r59usk02 1961 27 AHDS AHDS NNP cord-014516-r59usk02 1961 28 . . . cord-014516-r59usk02 1962 1 Although although IN cord-014516-r59usk02 1962 2 C. C. NNP cord-014516-r59usk02 1962 3 perfringens perfringen NNS cord-014516-r59usk02 1962 4 enterotoxinhas enterotoxinhas NNP cord-014516-r59usk02 1962 5 been be VBN cord-014516-r59usk02 1962 6 associated associate VBN cord-014516-r59usk02 1962 7 with with IN cord-014516-r59usk02 1962 8 intestinal intestinal JJ cord-014516-r59usk02 1962 9 diseases disease NNS cord-014516-r59usk02 1962 10 in in IN cord-014516-r59usk02 1962 11 humans human NNS cord-014516-r59usk02 1962 12 , , , cord-014516-r59usk02 1962 13 dogs dog NNS cord-014516-r59usk02 1962 14 , , , cord-014516-r59usk02 1962 15 horses horse NNS cord-014516-r59usk02 1962 16 , , , cord-014516-r59usk02 1962 17 pigs pig NNS cord-014516-r59usk02 1962 18 , , , cord-014516-r59usk02 1962 19 and and CC cord-014516-r59usk02 1962 20 other other JJ cord-014516-r59usk02 1962 21 animal animal NN cord-014516-r59usk02 1962 22 species specie NNS cord-014516-r59usk02 1962 23 , , , cord-014516-r59usk02 1962 24 this this DT cord-014516-r59usk02 1962 25 enterotoxin enterotoxin NN cord-014516-r59usk02 1962 26 is be VBZ cord-014516-r59usk02 1962 27 most most RBS cord-014516-r59usk02 1962 28 likely likely JJ cord-014516-r59usk02 1962 29 not not RB cord-014516-r59usk02 1962 30 responsible responsible JJ cord-014516-r59usk02 1962 31 for for IN cord-014516-r59usk02 1962 32 the the DT cord-014516-r59usk02 1962 33 intestinal intestinal JJ cord-014516-r59usk02 1962 34 lesions lesion NNS cord-014516-r59usk02 1962 35 in in IN cord-014516-r59usk02 1962 36 dogs dog NNS cord-014516-r59usk02 1962 37 with with IN cord-014516-r59usk02 1962 38 AHDS AHDS NNP cord-014516-r59usk02 1962 39 . . . cord-014516-r59usk02 1963 1 No no DT cord-014516-r59usk02 1963 2 conflicts conflict NNS cord-014516-r59usk02 1963 3 of of IN cord-014516-r59usk02 1963 4 interest interest NN cord-014516-r59usk02 1963 5 reported report VBN cord-014516-r59usk02 1963 6 . . . cord-014516-r59usk02 1964 1 p p NN cord-014516-r59usk02 1964 2 < < XX cord-014516-r59usk02 1964 3 0.000 0.000 CD cord-014516-r59usk02 1964 4 ) ) -RRB- cord-014516-r59usk02 1964 5 . . . cord-014516-r59usk02 1965 1 Lack lack NN cord-014516-r59usk02 1965 2 of of IN cord-014516-r59usk02 1965 3 treatment treatment NN cord-014516-r59usk02 1965 4 response response NN cord-014516-r59usk02 1965 5 was be VBD cord-014516-r59usk02 1965 6 significantly significantly RB cord-014516-r59usk02 1965 7 associated associate VBN cord-014516-r59usk02 1965 8 with with IN cord-014516-r59usk02 1965 9 IL IL NNP cord-014516-r59usk02 1965 10 ( ( -LRB- cord-014516-r59usk02 1965 11 IL IL NNP cord-014516-r59usk02 1965 12 : : : cord-014516-r59usk02 1965 13 3/4 3/4 CD cord-014516-r59usk02 1965 14 , , , cord-014516-r59usk02 1966 1 SRE sre RB cord-014516-r59usk02 1966 2 : : : cord-014516-r59usk02 1967 1 6/20 6/20 CD cord-014516-r59usk02 1967 2 , , , cord-014516-r59usk02 1967 3 FRE FRE NNP cord-014516-r59usk02 1967 4 : : : cord-014516-r59usk02 1967 5 0/63 0/63 CD cord-014516-r59usk02 1967 6 , , , cord-014516-r59usk02 1967 7 ARE are VBP cord-014516-r59usk02 1967 8 : : : cord-014516-r59usk02 1967 9 0/11 0/11 CD cord-014516-r59usk02 1967 10 ; ; : cord-014516-r59usk02 1967 11 p p NN cord-014516-r59usk02 1967 12 < < XX cord-014516-r59usk02 1967 13 0.000 0.000 CD cord-014516-r59usk02 1967 14 ) ) -RRB- cord-014516-r59usk02 1967 15 . . . cord-014516-r59usk02 1968 1 Anemia anemia NN cord-014516-r59usk02 1968 2 , , , cord-014516-r59usk02 1968 3 thrombocytopenia thrombocytopenia NN cord-014516-r59usk02 1968 4 , , , cord-014516-r59usk02 1968 5 and and CC cord-014516-r59usk02 1968 6 increased increase VBN cord-014516-r59usk02 1968 7 plasma plasma NN cord-014516-r59usk02 1968 8 urea urea NN cord-014516-r59usk02 1968 9 were be VBD cord-014516-r59usk02 1968 10 significantly significantly RB cord-014516-r59usk02 1968 11 associated associate VBN cord-014516-r59usk02 1968 12 with with IN cord-014516-r59usk02 1968 13 IL IL NNP cord-014516-r59usk02 1968 14 ( ( -LRB- cord-014516-r59usk02 1968 15 anemia anemia NN cord-014516-r59usk02 1968 16 : : : cord-014516-r59usk02 1968 17 IL IL NNP cord-014516-r59usk02 1968 18 : : : cord-014516-r59usk02 1968 19 4/5 4/5 CD cord-014516-r59usk02 1968 20 , , , cord-014516-r59usk02 1968 21 SRE SRE NNP cord-014516-r59usk02 1968 22 : : : cord-014516-r59usk02 1968 23 13/22 13/22 CD cord-014516-r59usk02 1968 24 , , , cord-014516-r59usk02 1968 25 FRE FRE NNP cord-014516-r59usk02 1968 26 : : : cord-014516-r59usk02 1968 27 11/64 11/64 CD cord-014516-r59usk02 1968 28 , , , cord-014516-r59usk02 1968 29 ARE are VBP cord-014516-r59usk02 1968 30 : : : cord-014516-r59usk02 1968 31 5/11 5/11 CD cord-014516-r59usk02 1968 32 , , , cord-014516-r59usk02 1968 33 p p NN cord-014516-r59usk02 1968 34 < < XX cord-014516-r59usk02 1968 35 0.000 0.000 XX cord-014516-r59usk02 1968 36 ; ; : cord-014516-r59usk02 1968 37 thrombocytopenia thrombocytopenia NN cord-014516-r59usk02 1968 38 : : : cord-014516-r59usk02 1968 39 IL IL NNP cord-014516-r59usk02 1968 40 : : : cord-014516-r59usk02 1969 1 3/5 3/5 CD cord-014516-r59usk02 1969 2 , , , cord-014516-r59usk02 1969 3 SRE sre RB cord-014516-r59usk02 1969 4 : : : cord-014516-r59usk02 1969 5 0/22 0/22 CD cord-014516-r59usk02 1970 1 , , , cord-014516-r59usk02 1970 2 FRE FRE NNP cord-014516-r59usk02 1970 3 : : : cord-014516-r59usk02 1970 4 4/64 4/64 CD cord-014516-r59usk02 1970 5 , , , cord-014516-r59usk02 1970 6 ARE are VBP cord-014516-r59usk02 1970 7 : : : cord-014516-r59usk02 1970 8 0/11 0/11 CD cord-014516-r59usk02 1971 1 , , , cord-014516-r59usk02 1971 2 p p NN cord-014516-r59usk02 1971 3 = = SYM cord-014516-r59usk02 1971 4 0.004 0.004 CD cord-014516-r59usk02 1971 5 ; ; , cord-014516-r59usk02 1971 6 increased increase VBN cord-014516-r59usk02 1971 7 urea urea NN cord-014516-r59usk02 1971 8 : : : cord-014516-r59usk02 1971 9 IL il NN cord-014516-r59usk02 1971 10 : : : cord-014516-r59usk02 1972 1 3/5 3/5 CD cord-014516-r59usk02 1972 2 , , , cord-014516-r59usk02 1972 3 SRE SRE NNP cord-014516-r59usk02 1972 4 : : : cord-014516-r59usk02 1972 5 1/22 1/22 CD cord-014516-r59usk02 1972 6 , , , cord-014516-r59usk02 1972 7 FRE FRE NNP cord-014516-r59usk02 1972 8 : : : cord-014516-r59usk02 1972 9 2/62 2/62 CD cord-014516-r59usk02 1972 10 , , , cord-014516-r59usk02 1972 11 ARE are VBP cord-014516-r59usk02 1972 12 : : : cord-014516-r59usk02 1972 13 1/11 1/11 CD cord-014516-r59usk02 1972 14 , , , cord-014516-r59usk02 1972 15 p p NN cord-014516-r59usk02 1972 16 = = SYM cord-014516-r59usk02 1972 17 0.003 0.003 CD cord-014516-r59usk02 1972 18 ) ) -RRB- cord-014516-r59usk02 1972 19 . . . cord-014516-r59usk02 1973 1 Hypoalbuminemia Hypoalbuminemia NNP cord-014516-r59usk02 1973 2 ( ( -LRB- cord-014516-r59usk02 1973 3 < < XX cord-014516-r59usk02 1973 4 20 20 CD cord-014516-r59usk02 1973 5 g g NN cord-014516-r59usk02 1973 6 / / SYM cord-014516-r59usk02 1973 7 L L NNP cord-014516-r59usk02 1973 8 ) ) -RRB- cord-014516-r59usk02 1973 9 and and CC cord-014516-r59usk02 1973 10 hypocobalaminemia hypocobalaminemia NNP cord-014516-r59usk02 1973 11 ( ( -LRB- cord-014516-r59usk02 1973 12 < < NNP cord-014516-r59usk02 1973 13 200 200 CD cord-014516-r59usk02 1973 14 pg pg NN cord-014516-r59usk02 1973 15 / / SYM cord-014516-r59usk02 1973 16 mL mL NNP cord-014516-r59usk02 1973 17 ) ) -RRB- cord-014516-r59usk02 1973 18 occurred occur VBD cord-014516-r59usk02 1973 19 significantly significantly RB cord-014516-r59usk02 1973 20 more more RBR cord-014516-r59usk02 1973 21 frequently frequently RB cord-014516-r59usk02 1973 22 in in IN cord-014516-r59usk02 1973 23 dogs dog NNS cord-014516-r59usk02 1973 24 with with IN cord-014516-r59usk02 1973 25 SRE SRE NNP cord-014516-r59usk02 1973 26 ( ( -LRB- cord-014516-r59usk02 1973 27 hypoalbuminemia hypoalbuminemia NN cord-014516-r59usk02 1973 28 : : : cord-014516-r59usk02 1974 1 IL IL NNP cord-014516-r59usk02 1974 2 : : : cord-014516-r59usk02 1974 3 0/5 0/5 CD cord-014516-r59usk02 1974 4 , , , cord-014516-r59usk02 1974 5 SRE SRE NNP cord-014516-r59usk02 1974 6 : : : cord-014516-r59usk02 1974 7 10/22 10/22 CD cord-014516-r59usk02 1974 8 , , , cord-014516-r59usk02 1974 9 FRE FRE NNP cord-014516-r59usk02 1974 10 : : : cord-014516-r59usk02 1974 11 1/62 1/62 CD cord-014516-r59usk02 1974 12 , , , cord-014516-r59usk02 1974 13 ARE are VBP cord-014516-r59usk02 1974 14 : : : cord-014516-r59usk02 1974 15 1/11 1/11 CD cord-014516-r59usk02 1974 16 , , , cord-014516-r59usk02 1974 17 p p NN cord-014516-r59usk02 1974 18 < < XX cord-014516-r59usk02 1974 19 0.000 0.000 XX cord-014516-r59usk02 1974 20 ; ; . cord-014516-r59usk02 1975 1 hypocobalaminemia hypocobalaminemia NNP cord-014516-r59usk02 1975 2 : : : cord-014516-r59usk02 1975 3 IL IL NNP cord-014516-r59usk02 1975 4 : : : cord-014516-r59usk02 1975 5 0/3 0/3 ADD cord-014516-r59usk02 1975 6 , , , cord-014516-r59usk02 1976 1 SRE sre RB cord-014516-r59usk02 1976 2 : : : cord-014516-r59usk02 1977 1 9/20 9/20 CD cord-014516-r59usk02 1977 2 , , , cord-014516-r59usk02 1977 3 FRE FRE NNP cord-014516-r59usk02 1977 4 : : : cord-014516-r59usk02 1977 5 8/63 8/63 CD cord-014516-r59usk02 1977 6 , , , cord-014516-r59usk02 1977 7 ARE are VBP cord-014516-r59usk02 1977 8 : : : cord-014516-r59usk02 1977 9 1/11 1/11 CD cord-014516-r59usk02 1977 10 , , , cord-014516-r59usk02 1977 11 p p NN cord-014516-r59usk02 1977 12 = = SYM cord-014516-r59usk02 1977 13 0.015 0.015 CD cord-014516-r59usk02 1977 14 ) ) -RRB- cord-014516-r59usk02 1977 15 . . . cord-014516-r59usk02 1978 1 Results result NNS cord-014516-r59usk02 1978 2 of of IN cord-014516-r59usk02 1978 3 this this DT cord-014516-r59usk02 1978 4 study study NN cord-014516-r59usk02 1978 5 show show VBP cord-014516-r59usk02 1978 6 that that IN cord-014516-r59usk02 1978 7 elderly elderly JJ cord-014516-r59usk02 1978 8 and and CC cord-014516-r59usk02 1978 9 large large JJ cord-014516-r59usk02 1978 10 breed breed NN cord-014516-r59usk02 1978 11 dogs dog NNS cord-014516-r59usk02 1978 12 were be VBD cord-014516-r59usk02 1978 13 more more RBR cord-014516-r59usk02 1978 14 frequently frequently RB cord-014516-r59usk02 1978 15 affected affect VBN cord-014516-r59usk02 1978 16 with with IN cord-014516-r59usk02 1978 17 IL IL NNP cord-014516-r59usk02 1978 18 and and CC cord-014516-r59usk02 1978 19 SRE SRE NNP cord-014516-r59usk02 1978 20 compared compare VBN cord-014516-r59usk02 1978 21 to to IN cord-014516-r59usk02 1978 22 other other JJ cord-014516-r59usk02 1978 23 etiologies etiology NNS cord-014516-r59usk02 1978 24 and and CC cord-014516-r59usk02 1978 25 both both CC cord-014516-r59usk02 1978 26 IL IL NNP cord-014516-r59usk02 1978 27 and and CC cord-014516-r59usk02 1978 28 SRE SRE NNP cord-014516-r59usk02 1978 29 were be VBD cord-014516-r59usk02 1978 30 associated associate VBN cord-014516-r59usk02 1978 31 with with IN cord-014516-r59usk02 1978 32 greater great JJR cord-014516-r59usk02 1978 33 disease disease NN cord-014516-r59usk02 1978 34 severity severity NN cord-014516-r59usk02 1978 35 and/or and/or CC cord-014516-r59usk02 1978 36 a a DT cord-014516-r59usk02 1978 37 negative negative JJ cord-014516-r59usk02 1978 38 outcome outcome NN cord-014516-r59usk02 1978 39 . . . cord-014516-r59usk02 1979 1 In in IN cord-014516-r59usk02 1979 2 comparison comparison NN cord-014516-r59usk02 1979 3 , , , cord-014516-r59usk02 1979 4 anemia anemia NN cord-014516-r59usk02 1979 5 , , , cord-014516-r59usk02 1979 6 thrombocytopenia thrombocytopenia NN cord-014516-r59usk02 1979 7 , , , cord-014516-r59usk02 1979 8 and and CC cord-014516-r59usk02 1979 9 increased increase VBN cord-014516-r59usk02 1979 10 plasma plasma NN cord-014516-r59usk02 1979 11 urea urea NN cord-014516-r59usk02 1979 12 were be VBD cord-014516-r59usk02 1979 13 most most RBS cord-014516-r59usk02 1979 14 frequently frequently RB cord-014516-r59usk02 1979 15 detected detect VBN cord-014516-r59usk02 1979 16 in in IN cord-014516-r59usk02 1979 17 IL IL NNP cord-014516-r59usk02 1979 18 whereas whereas IN cord-014516-r59usk02 1979 19 severe severe JJ cord-014516-r59usk02 1979 20 hypoalbuminemia hypoalbuminemia NN cord-014516-r59usk02 1979 21 and and CC cord-014516-r59usk02 1979 22 hypocobalaminemia hypocobalaminemia NNP cord-014516-r59usk02 1979 23 were be VBD cord-014516-r59usk02 1979 24 significantly significantly RB cord-014516-r59usk02 1979 25 associated associate VBN cord-014516-r59usk02 1979 26 with with IN cord-014516-r59usk02 1979 27 SRE SRE NNP cord-014516-r59usk02 1979 28 . . . cord-014516-r59usk02 1980 1 No no DT cord-014516-r59usk02 1980 2 conflicts conflict NNS cord-014516-r59usk02 1980 3 of of IN cord-014516-r59usk02 1980 4 interest interest NN cord-014516-r59usk02 1980 5 reported report VBN cord-014516-r59usk02 1980 6 . . . cord-014516-r59usk02 1981 1 Alpha alpha NN cord-014516-r59usk02 1981 2 1 1 CD cord-014516-r59usk02 1981 3 -proteinase -proteinase NN cord-014516-r59usk02 1981 4 inhibitor inhibitor NN cord-014516-r59usk02 1981 5 ( ( -LRB- cord-014516-r59usk02 1981 6 a a DT cord-014516-r59usk02 1981 7 1 1 CD cord-014516-r59usk02 1981 8 -PI -pi NN cord-014516-r59usk02 1981 9 ) ) -RRB- cord-014516-r59usk02 1981 10 is be VBZ cord-014516-r59usk02 1981 11 a a DT cord-014516-r59usk02 1981 12 proteinase proteinase NN cord-014516-r59usk02 1981 13 - - HYPH cord-014516-r59usk02 1981 14 resistent resistent NN cord-014516-r59usk02 1981 15 protein protein NN cord-014516-r59usk02 1981 16 that that WDT cord-014516-r59usk02 1981 17 can can MD cord-014516-r59usk02 1981 18 be be VB cord-014516-r59usk02 1981 19 quantified quantify VBN cord-014516-r59usk02 1981 20 in in IN cord-014516-r59usk02 1981 21 fecal fecal JJ cord-014516-r59usk02 1981 22 , , , cord-014516-r59usk02 1981 23 urine urine NN cord-014516-r59usk02 1981 24 , , , cord-014516-r59usk02 1981 25 and and CC cord-014516-r59usk02 1981 26 serum serum NN cord-014516-r59usk02 1981 27 samples sample NNS cord-014516-r59usk02 1981 28 from from IN cord-014516-r59usk02 1981 29 dogs dog NNS cord-014516-r59usk02 1981 30 . . . cord-014516-r59usk02 1982 1 Recently recently RB cord-014516-r59usk02 1982 2 , , , cord-014516-r59usk02 1982 3 increased increase VBN cord-014516-r59usk02 1982 4 fecal fecal JJ cord-014516-r59usk02 1982 5 and and CC cord-014516-r59usk02 1982 6 urinary urinary JJ cord-014516-r59usk02 1982 7 canine canine NN cord-014516-r59usk02 1982 8 a a DT cord-014516-r59usk02 1982 9 1 1 CD cord-014516-r59usk02 1982 10 -PI -pi NN cord-014516-r59usk02 1982 11 ( ( -LRB- cord-014516-r59usk02 1982 12 ca ca NNP cord-014516-r59usk02 1982 13 1 1 CD cord-014516-r59usk02 1982 14 -PI -PI NNS cord-014516-r59usk02 1982 15 ) ) -RRB- cord-014516-r59usk02 1982 16 concentrations concentration NNS cord-014516-r59usk02 1982 17 have have VBP cord-014516-r59usk02 1982 18 been be VBN cord-014516-r59usk02 1982 19 described describe VBN cord-014516-r59usk02 1982 20 in in IN cord-014516-r59usk02 1982 21 dogs dog NNS cord-014516-r59usk02 1982 22 with with IN cord-014516-r59usk02 1982 23 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 1982 24 diseases disease NNS cord-014516-r59usk02 1982 25 ( ( -LRB- cord-014516-r59usk02 1982 26 e.g. e.g. RB cord-014516-r59usk02 1982 27 , , , cord-014516-r59usk02 1982 28 inflammatory inflammatory JJ cord-014516-r59usk02 1982 29 bowel bowel NN cord-014516-r59usk02 1982 30 disease disease NN cord-014516-r59usk02 1982 31 [ [ -LRB- cord-014516-r59usk02 1982 32 IBD IBD NNP cord-014516-r59usk02 1982 33 ] ] -RRB- cord-014516-r59usk02 1982 34 , , , cord-014516-r59usk02 1982 35 but but CC cord-014516-r59usk02 1982 36 also also RB cord-014516-r59usk02 1982 37 in in IN cord-014516-r59usk02 1982 38 dogs dog NNS cord-014516-r59usk02 1982 39 with with IN cord-014516-r59usk02 1982 40 exocrine exocrine JJ cord-014516-r59usk02 1982 41 pancreatic pancreatic JJ cord-014516-r59usk02 1982 42 insufficiency insufficiency NN cord-014516-r59usk02 1982 43 ) ) -RRB- cord-014516-r59usk02 1982 44 and and CC cord-014516-r59usk02 1982 45 in in IN cord-014516-r59usk02 1982 46 dogs dog NNS cord-014516-r59usk02 1982 47 with with IN cord-014516-r59usk02 1982 48 chronic chronic JJ cord-014516-r59usk02 1982 49 hepatitis hepatitis NN cord-014516-r59usk02 1982 50 or or CC cord-014516-r59usk02 1982 51 chronic chronic JJ cord-014516-r59usk02 1982 52 kidney kidney NN cord-014516-r59usk02 1982 53 disease disease NN cord-014516-r59usk02 1982 54 , , , cord-014516-r59usk02 1982 55 respectively respectively RB cord-014516-r59usk02 1982 56 . . . cord-014516-r59usk02 1983 1 Decreased decrease VBN cord-014516-r59usk02 1983 2 serum serum NN cord-014516-r59usk02 1984 1 ca ca NNP cord-014516-r59usk02 1985 1 1 1 LS cord-014516-r59usk02 1985 2 -PI -PI NNS cord-014516-r59usk02 1985 3 concentrations concentration NNS cord-014516-r59usk02 1985 4 have have VBP cord-014516-r59usk02 1985 5 been be VBN cord-014516-r59usk02 1985 6 reported report VBN cord-014516-r59usk02 1985 7 in in IN cord-014516-r59usk02 1985 8 dogs dog NNS cord-014516-r59usk02 1985 9 with with IN cord-014516-r59usk02 1985 10 IBD IBD NNP cord-014516-r59usk02 1985 11 , , , cord-014516-r59usk02 1985 12 protein protein NN cord-014516-r59usk02 1985 13 - - HYPH cord-014516-r59usk02 1985 14 losing lose VBG cord-014516-r59usk02 1985 15 enteropathy enteropathy NNS cord-014516-r59usk02 1985 16 ( ( -LRB- cord-014516-r59usk02 1985 17 PLE PLE NNP cord-014516-r59usk02 1985 18 ) ) -RRB- cord-014516-r59usk02 1985 19 , , , cord-014516-r59usk02 1985 20 and and CC cord-014516-r59usk02 1985 21 hypocobalaminemia hypocobalaminemia NN cord-014516-r59usk02 1985 22 . . . cord-014516-r59usk02 1986 1 Treatment treatment NN cord-014516-r59usk02 1986 2 protocols protocol NNS cord-014516-r59usk02 1986 3 for for IN cord-014516-r59usk02 1986 4 dogs dog NNS cord-014516-r59usk02 1986 5 with with IN cord-014516-r59usk02 1986 6 IBD IBD NNP cord-014516-r59usk02 1986 7 and/or and/or CC cord-014516-r59usk02 1986 8 PLE PLE NNP cord-014516-r59usk02 1986 9 commonly commonly RB cord-014516-r59usk02 1986 10 include include VBP cord-014516-r59usk02 1986 11 corticosteroids corticosteroid NNS cord-014516-r59usk02 1986 12 , , , cord-014516-r59usk02 1986 13 but but CC cord-014516-r59usk02 1986 14 the the DT cord-014516-r59usk02 1986 15 effect effect NN cord-014516-r59usk02 1986 16 of of IN cord-014516-r59usk02 1986 17 corticosteroid corticosteroid NN cord-014516-r59usk02 1986 18 therapy therapy NN cord-014516-r59usk02 1986 19 on on IN cord-014516-r59usk02 1986 20 serum serum NN cord-014516-r59usk02 1986 21 ca ca NNP cord-014516-r59usk02 1986 22 1 1 CD cord-014516-r59usk02 1986 23 -PI -PI NNS cord-014516-r59usk02 1986 24 concentrations concentration NNS cord-014516-r59usk02 1986 25 have have VBP cord-014516-r59usk02 1986 26 not not RB cord-014516-r59usk02 1986 27 yet yet RB cord-014516-r59usk02 1986 28 been be VBN cord-014516-r59usk02 1986 29 reported report VBN cord-014516-r59usk02 1986 30 . . . cord-014516-r59usk02 1987 1 The the DT cord-014516-r59usk02 1987 2 aim aim NN cord-014516-r59usk02 1987 3 of of IN cord-014516-r59usk02 1987 4 this this DT cord-014516-r59usk02 1987 5 study study NN cord-014516-r59usk02 1987 6 was be VBD cord-014516-r59usk02 1987 7 to to TO cord-014516-r59usk02 1987 8 evaluate evaluate VB cord-014516-r59usk02 1987 9 the the DT cord-014516-r59usk02 1987 10 effect effect NN cord-014516-r59usk02 1987 11 of of IN cord-014516-r59usk02 1987 12 hydro hydro NN cord-014516-r59usk02 1987 13 - - HYPH cord-014516-r59usk02 1987 14 cortisone cortisone NN cord-014516-r59usk02 1987 15 on on IN cord-014516-r59usk02 1987 16 serum serum NN cord-014516-r59usk02 1987 17 ca ca NN cord-014516-r59usk02 1987 18 1 1 CD cord-014516-r59usk02 1987 19 -PI -PI NNS cord-014516-r59usk02 1987 20 concentrations concentration NNS cord-014516-r59usk02 1987 21 in in IN cord-014516-r59usk02 1987 22 healthy healthy JJ cord-014516-r59usk02 1987 23 dogs dog NNS cord-014516-r59usk02 1987 24 . . . cord-014516-r59usk02 1988 1 Twelve twelve CD cord-014516-r59usk02 1988 2 healthy healthy JJ cord-014516-r59usk02 1988 3 Beagle Beagle NNP cord-014516-r59usk02 1988 4 dogs dog NNS cord-014516-r59usk02 1988 5 were be VBD cord-014516-r59usk02 1988 6 randomly randomly RB cord-014516-r59usk02 1988 7 allocated allocate VBN cord-014516-r59usk02 1988 8 to to IN cord-014516-r59usk02 1988 9 a a DT cord-014516-r59usk02 1988 10 placebo placebo NN cord-014516-r59usk02 1988 11 - - HYPH cord-014516-r59usk02 1988 12 group group NN cord-014516-r59usk02 1988 13 ( ( -LRB- cord-014516-r59usk02 1988 14 n n NN cord-014516-r59usk02 1988 15 = = SYM cord-014516-r59usk02 1988 16 6 6 CD cord-014516-r59usk02 1988 17 ) ) -RRB- cord-014516-r59usk02 1988 18 and and CC cord-014516-r59usk02 1988 19 to to IN cord-014516-r59usk02 1988 20 a a DT cord-014516-r59usk02 1988 21 treatment treatment NN cord-014516-r59usk02 1988 22 group group NN cord-014516-r59usk02 1988 23 ( ( -LRB- cord-014516-r59usk02 1988 24 n n NN cord-014516-r59usk02 1988 25 = = SYM cord-014516-r59usk02 1988 26 6 6 CD cord-014516-r59usk02 1988 27 ; ; : cord-014516-r59usk02 1988 28 hydrocortisone hydrocortisone NN cord-014516-r59usk02 1988 29 - - HYPH cord-014516-r59usk02 1988 30 group group NN cord-014516-r59usk02 1988 31 ) ) -RRB- cord-014516-r59usk02 1988 32 . . . cord-014516-r59usk02 1989 1 The the DT cord-014516-r59usk02 1989 2 placebo placebo NN cord-014516-r59usk02 1989 3 - - HYPH cord-014516-r59usk02 1989 4 group group NN cord-014516-r59usk02 1989 5 received receive VBD cord-014516-r59usk02 1989 6 an an DT cord-014516-r59usk02 1989 7 empty empty JJ cord-014516-r59usk02 1989 8 gelatin gelatin NN cord-014516-r59usk02 1989 9 capsule capsule NN cord-014516-r59usk02 1989 10 PO po NN cord-014516-r59usk02 1989 11 q12 q12 NN cord-014516-r59usk02 1989 12 h h NNP cord-014516-r59usk02 1989 13 , , , cord-014516-r59usk02 1989 14 whereas whereas IN cord-014516-r59usk02 1989 15 the the DT cord-014516-r59usk02 1989 16 hydrocortisone hydrocortisone NN cord-014516-r59usk02 1989 17 - - HYPH cord-014516-r59usk02 1989 18 group group NN cord-014516-r59usk02 1989 19 was be VBD cord-014516-r59usk02 1989 20 treated treat VBN cord-014516-r59usk02 1989 21 with with IN cord-014516-r59usk02 1989 22 hydrocortisone hydrocortisone NN cord-014516-r59usk02 1989 23 at at IN cord-014516-r59usk02 1989 24 a a DT cord-014516-r59usk02 1989 25 dose dose NN cord-014516-r59usk02 1989 26 of of IN cord-014516-r59usk02 1989 27 8.5 8.5 CD cord-014516-r59usk02 1989 28 mg mg NNP cord-014516-r59usk02 1989 29 / / SYM cord-014516-r59usk02 1989 30 kg kg NNP cord-014516-r59usk02 1989 31 PO PO NNP cord-014516-r59usk02 1989 32 q12 q12 NN cord-014516-r59usk02 1989 33 h. h. NNP cord-014516-r59usk02 1989 34 Serum serum NN cord-014516-r59usk02 1989 35 samples sample NNS cord-014516-r59usk02 1989 36 were be VBD cord-014516-r59usk02 1989 37 obtained obtain VBN cord-014516-r59usk02 1989 38 at at IN cord-014516-r59usk02 1989 39 baseline baseline NN cord-014516-r59usk02 1989 40 and and CC cord-014516-r59usk02 1989 41 on on IN cord-014516-r59usk02 1989 42 day day NN cord-014516-r59usk02 1989 43 1 1 CD cord-014516-r59usk02 1989 44 , , , cord-014516-r59usk02 1989 45 5 5 CD cord-014516-r59usk02 1989 46 , , , cord-014516-r59usk02 1989 47 28 28 CD cord-014516-r59usk02 1989 48 , , , cord-014516-r59usk02 1989 49 56 56 CD cord-014516-r59usk02 1989 50 , , , cord-014516-r59usk02 1989 51 and and CC cord-014516-r59usk02 1989 52 84 84 CD cord-014516-r59usk02 1989 53 during during IN cord-014516-r59usk02 1989 54 treatment treatment NN cord-014516-r59usk02 1989 55 as as RB cord-014516-r59usk02 1989 56 well well RB cord-014516-r59usk02 1989 57 as as IN cord-014516-r59usk02 1989 58 day day NN cord-014516-r59usk02 1989 59 1 1 CD cord-014516-r59usk02 1989 60 , , , cord-014516-r59usk02 1989 61 5 5 CD cord-014516-r59usk02 1989 62 , , , cord-014516-r59usk02 1989 63 28 28 CD cord-014516-r59usk02 1989 64 , , , cord-014516-r59usk02 1989 65 56 56 CD cord-014516-r59usk02 1989 66 , , , cord-014516-r59usk02 1989 67 and and CC cord-014516-r59usk02 1989 68 84 84 CD cord-014516-r59usk02 1989 69 post post NN cord-014516-r59usk02 1989 70 - - NN cord-014516-r59usk02 1989 71 treatment treatment NN cord-014516-r59usk02 1989 72 for for IN cord-014516-r59usk02 1989 73 all all DT cord-014516-r59usk02 1989 74 dogs dog NNS cord-014516-r59usk02 1989 75 . . . cord-014516-r59usk02 1990 1 Serum serum NN cord-014516-r59usk02 1990 2 ca ca NN cord-014516-r59usk02 1991 1 1 1 LS cord-014516-r59usk02 1991 2 -PI -PI NNS cord-014516-r59usk02 1991 3 concentrations concentration NNS cord-014516-r59usk02 1991 4 were be VBD cord-014516-r59usk02 1991 5 measured measure VBN cord-014516-r59usk02 1991 6 at at IN cord-014516-r59usk02 1991 7 all all DT cord-014516-r59usk02 1991 8 time time NN cord-014516-r59usk02 1991 9 points point NNS cord-014516-r59usk02 1991 10 using use VBG cord-014516-r59usk02 1991 11 an an DT cord-014516-r59usk02 1991 12 in in IN cord-014516-r59usk02 1991 13 - - HYPH cord-014516-r59usk02 1991 14 house house NN cord-014516-r59usk02 1991 15 radioimmunoassay radioimmunoassay NN cord-014516-r59usk02 1991 16 . . . cord-014516-r59usk02 1992 1 A a DT cord-014516-r59usk02 1992 2 Mann Mann NNP cord-014516-r59usk02 1992 3 - - HYPH cord-014516-r59usk02 1992 4 Whitney Whitney NNP cord-014516-r59usk02 1992 5 U U NNP cord-014516-r59usk02 1992 6 test test NN cord-014516-r59usk02 1992 7 was be VBD cord-014516-r59usk02 1992 8 used use VBN cord-014516-r59usk02 1992 9 to to TO cord-014516-r59usk02 1992 10 compare compare VB cord-014516-r59usk02 1992 11 the the DT cord-014516-r59usk02 1992 12 baseline baseline JJ cord-014516-r59usk02 1992 13 measurements measurement NNS cord-014516-r59usk02 1992 14 of of IN cord-014516-r59usk02 1992 15 both both DT cord-014516-r59usk02 1992 16 groups group NNS cord-014516-r59usk02 1992 17 . . . cord-014516-r59usk02 1993 1 The the DT cord-014516-r59usk02 1993 2 effect effect NN cord-014516-r59usk02 1993 3 of of IN cord-014516-r59usk02 1993 4 hydrocortisone hydrocortisone NN cord-014516-r59usk02 1993 5 - - HYPH cord-014516-r59usk02 1993 6 treatment treatment NN cord-014516-r59usk02 1993 7 on on IN cord-014516-r59usk02 1993 8 serum serum NN cord-014516-r59usk02 1994 1 ca ca NNP cord-014516-r59usk02 1995 1 1 1 LS cord-014516-r59usk02 1995 2 -PI -PI NNS cord-014516-r59usk02 1995 3 concentrations concentration NNS cord-014516-r59usk02 1995 4 was be VBD cord-014516-r59usk02 1995 5 evaluated evaluate VBN cord-014516-r59usk02 1995 6 by by IN cord-014516-r59usk02 1995 7 comparing compare VBG cord-014516-r59usk02 1995 8 ca ca NNP cord-014516-r59usk02 1995 9 1 1 CD cord-014516-r59usk02 1995 10 -PI -pi NN cord-014516-r59usk02 1995 11 at at IN cord-014516-r59usk02 1995 12 baseline baseline NN cord-014516-r59usk02 1995 13 and and CC cord-014516-r59usk02 1995 14 during during IN cord-014516-r59usk02 1995 15 treatment treatment NN cord-014516-r59usk02 1995 16 and and CC cord-014516-r59usk02 1995 17 between between IN cord-014516-r59usk02 1995 18 baseline baseline NN cord-014516-r59usk02 1995 19 and and CC cord-014516-r59usk02 1995 20 posttreatment posttreatment NN cord-014516-r59usk02 1995 21 period period NN cord-014516-r59usk02 1995 22 using use VBG cord-014516-r59usk02 1995 23 a a DT cord-014516-r59usk02 1995 24 MANOVA MANOVA NNP cord-014516-r59usk02 1995 25 . . . cord-014516-r59usk02 1996 1 Baseline baseline JJ cord-014516-r59usk02 1996 2 serum serum NN cord-014516-r59usk02 1996 3 ca ca NN cord-014516-r59usk02 1996 4 1 1 CD cord-014516-r59usk02 1996 5 -PI -PI NNS cord-014516-r59usk02 1996 6 concentrations concentration NNS cord-014516-r59usk02 1996 7 did do VBD cord-014516-r59usk02 1996 8 not not RB cord-014516-r59usk02 1996 9 differ differ VB cord-014516-r59usk02 1996 10 between between IN cord-014516-r59usk02 1996 11 the the DT cord-014516-r59usk02 1996 12 hydrocortisone hydrocortisone NN cord-014516-r59usk02 1996 13 - - : cord-014516-r59usk02 1996 14 and and CC cord-014516-r59usk02 1996 15 the the DT cord-014516-r59usk02 1996 16 placebo placebo NN cord-014516-r59usk02 1996 17 - - HYPH cord-014516-r59usk02 1996 18 group group NN cord-014516-r59usk02 1996 19 ( ( -LRB- cord-014516-r59usk02 1996 20 p p NN cord-014516-r59usk02 1996 21 > > XX cord-014516-r59usk02 1996 22 0.05 0.05 CD cord-014516-r59usk02 1996 23 ) ) -RRB- cord-014516-r59usk02 1996 24 . . . cord-014516-r59usk02 1997 1 Serum serum NN cord-014516-r59usk02 1997 2 ca ca NN cord-014516-r59usk02 1998 1 1 1 LS cord-014516-r59usk02 1998 2 -PI -PI NNS cord-014516-r59usk02 1998 3 concentrations concentration NNS cord-014516-r59usk02 1998 4 increased increase VBD cord-014516-r59usk02 1998 5 significantly significantly RB cord-014516-r59usk02 1998 6 ( ( -LRB- cord-014516-r59usk02 1998 7 p p NN cord-014516-r59usk02 1998 8 = = SYM cord-014516-r59usk02 1998 9 0.0004 0.0004 CD cord-014516-r59usk02 1998 10 ) ) -RRB- cord-014516-r59usk02 1998 11 during during IN cord-014516-r59usk02 1998 12 the the DT cord-014516-r59usk02 1998 13 treatment treatment NN cord-014516-r59usk02 1998 14 period period NN cord-014516-r59usk02 1998 15 in in IN cord-014516-r59usk02 1998 16 the the DT cord-014516-r59usk02 1998 17 hydrocortisone hydrocortisone NN cord-014516-r59usk02 1998 18 - - HYPH cord-014516-r59usk02 1998 19 group group NN cord-014516-r59usk02 1998 20 ( ( -LRB- cord-014516-r59usk02 1998 21 baseline baseline JJ cord-014516-r59usk02 1998 22 [ [ -LRB- cord-014516-r59usk02 1998 23 median median NN cord-014516-r59usk02 1998 24 in in IN cord-014516-r59usk02 1998 25 mg mg NNP cord-014516-r59usk02 1998 26 / / SYM cord-014516-r59usk02 1998 27 L l NN cord-014516-r59usk02 1998 28 : : : cord-014516-r59usk02 1998 29 1 1 CD cord-014516-r59usk02 1998 30 , , , cord-014516-r59usk02 1998 31 796 796 CD cord-014516-r59usk02 1998 32 ] ] -RRB- cord-014516-r59usk02 1998 33 ) ) -RRB- cord-014516-r59usk02 1998 34 . . . cord-014516-r59usk02 1999 1 In in IN cord-014516-r59usk02 1999 2 contrast contrast NN cord-014516-r59usk02 1999 3 , , , cord-014516-r59usk02 1999 4 no no DT cord-014516-r59usk02 1999 5 difference difference NN cord-014516-r59usk02 1999 6 was be VBD cord-014516-r59usk02 1999 7 observed observe VBN cord-014516-r59usk02 1999 8 between between IN cord-014516-r59usk02 1999 9 both both DT cord-014516-r59usk02 1999 10 groups group NNS cord-014516-r59usk02 1999 11 when when WRB cord-014516-r59usk02 1999 12 comparing compare VBG cord-014516-r59usk02 1999 13 serum serum NN cord-014516-r59usk02 1999 14 ca ca NNP cord-014516-r59usk02 1999 15 1 1 CD cord-014516-r59usk02 1999 16 -PI -PI NNS cord-014516-r59usk02 1999 17 concentrations concentration NNS cord-014516-r59usk02 1999 18 at at IN cord-014516-r59usk02 1999 19 baseline baseline NN cord-014516-r59usk02 1999 20 and and CC cord-014516-r59usk02 1999 21 during during IN cord-014516-r59usk02 1999 22 the the DT cord-014516-r59usk02 1999 23 post post JJ cord-014516-r59usk02 1999 24 - - JJ cord-014516-r59usk02 1999 25 treatment treatment JJ cord-014516-r59usk02 1999 26 period period NN cord-014516-r59usk02 1999 27 ( ( -LRB- cord-014516-r59usk02 1999 28 p p NN cord-014516-r59usk02 1999 29 > > XX cord-014516-r59usk02 1999 30 0.05 0.05 CD cord-014516-r59usk02 1999 31 ) ) -RRB- cord-014516-r59usk02 1999 32 . . . cord-014516-r59usk02 2000 1 This this DT cord-014516-r59usk02 2000 2 study study NN cord-014516-r59usk02 2000 3 showed show VBD cord-014516-r59usk02 2000 4 that that IN cord-014516-r59usk02 2000 5 hydrocortisone hydrocortisone NN cord-014516-r59usk02 2000 6 - - HYPH cord-014516-r59usk02 2000 7 treatment treatment NN cord-014516-r59usk02 2000 8 over over IN cord-014516-r59usk02 2000 9 12 12 CD cord-014516-r59usk02 2000 10 weeks week NNS cord-014516-r59usk02 2000 11 did do VBD cord-014516-r59usk02 2000 12 affect affect VB cord-014516-r59usk02 2000 13 serum serum NN cord-014516-r59usk02 2000 14 ca ca NN cord-014516-r59usk02 2000 15 1 1 CD cord-014516-r59usk02 2000 16 -PI -PI NNS cord-014516-r59usk02 2000 17 concentrations concentration NNS cord-014516-r59usk02 2000 18 in in IN cord-014516-r59usk02 2000 19 healthy healthy JJ cord-014516-r59usk02 2000 20 dogs dog NNS cord-014516-r59usk02 2000 21 . . . cord-014516-r59usk02 2001 1 Whether whether IN cord-014516-r59usk02 2001 2 corticosteroid corticosteroid NN cord-014516-r59usk02 2001 3 therapy therapy NN cord-014516-r59usk02 2001 4 has have VBZ cord-014516-r59usk02 2001 5 any any DT cord-014516-r59usk02 2001 6 effects effect NNS cord-014516-r59usk02 2001 7 on on IN cord-014516-r59usk02 2001 8 fecal fecal JJ cord-014516-r59usk02 2001 9 or or CC cord-014516-r59usk02 2001 10 urine urine NN cord-014516-r59usk02 2001 11 ca ca NNP cord-014516-r59usk02 2001 12 1 1 CD cord-014516-r59usk02 2001 13 -PI -PI NNS cord-014516-r59usk02 2001 14 concentrations concentration NNS cord-014516-r59usk02 2001 15 in in IN cord-014516-r59usk02 2001 16 healthy healthy JJ cord-014516-r59usk02 2001 17 dogs dog NNS cord-014516-r59usk02 2001 18 remains remain VBZ cord-014516-r59usk02 2001 19 to to TO cord-014516-r59usk02 2001 20 be be VB cord-014516-r59usk02 2001 21 determined determine VBN cord-014516-r59usk02 2001 22 . . . cord-014516-r59usk02 2002 1 The the DT cord-014516-r59usk02 2002 2 author author NN cord-014516-r59usk02 2002 3 works work VBZ cord-014516-r59usk02 2002 4 at at IN cord-014516-r59usk02 2002 5 Texas Texas NNP cord-014516-r59usk02 2002 6 A&M A&M NNP cord-014516-r59usk02 2002 7 University University NNP cord-014516-r59usk02 2002 8 , , , cord-014516-r59usk02 2002 9 whose whose WP$ cord-014516-r59usk02 2002 10 GI GI NNP cord-014516-r59usk02 2002 11 Lab Lab NNP cord-014516-r59usk02 2002 12 currently currently RB cord-014516-r59usk02 2002 13 offer offer VBP cord-014516-r59usk02 2002 14 a a DT cord-014516-r59usk02 2002 15 commercial commercial JJ cord-014516-r59usk02 2002 16 assay assay NN cord-014516-r59usk02 2002 17 for for IN cord-014516-r59usk02 2002 18 faecal faecal JJ cord-014516-r59usk02 2002 19 Alpha1-Proteinase Alpha1-Proteinase NNP cord-014516-r59usk02 2002 20 Inhibitor Inhibitor NNP cord-014516-r59usk02 2002 21 . . . cord-014516-r59usk02 2003 1 Canine canine JJ cord-014516-r59usk02 2003 2 chronic chronic NN cord-014516-r59usk02 2003 3 enteropathy enteropathy NN cord-014516-r59usk02 2003 4 ( ( -LRB- cord-014516-r59usk02 2003 5 CE CE NNP cord-014516-r59usk02 2003 6 ) ) -RRB- cord-014516-r59usk02 2003 7 is be VBZ cord-014516-r59usk02 2003 8 a a DT cord-014516-r59usk02 2003 9 common common JJ cord-014516-r59usk02 2003 10 , , , cord-014516-r59usk02 2003 11 but but CC cord-014516-r59usk02 2003 12 poorly poorly RB cord-014516-r59usk02 2003 13 understood understand VBD cord-014516-r59usk02 2003 14 syndrome syndrome NN cord-014516-r59usk02 2003 15 , , , cord-014516-r59usk02 2003 16 with with IN cord-014516-r59usk02 2003 17 variable variable JJ cord-014516-r59usk02 2003 18 response response NN cord-014516-r59usk02 2003 19 to to IN cord-014516-r59usk02 2003 20 therapy therapy NN cord-014516-r59usk02 2003 21 and and CC cord-014516-r59usk02 2003 22 prognosis prognosis NN cord-014516-r59usk02 2003 23 . . . cord-014516-r59usk02 2004 1 There there EX cord-014516-r59usk02 2004 2 is be VBZ cord-014516-r59usk02 2004 3 a a DT cord-014516-r59usk02 2004 4 need need NN cord-014516-r59usk02 2004 5 for for IN cord-014516-r59usk02 2004 6 novel novel JJ cord-014516-r59usk02 2004 7 biomarkers biomarker NNS cord-014516-r59usk02 2004 8 that that WDT cord-014516-r59usk02 2004 9 are be VBP cord-014516-r59usk02 2004 10 specific specific JJ cord-014516-r59usk02 2004 11 for for IN cord-014516-r59usk02 2004 12 intestinal intestinal JJ cord-014516-r59usk02 2004 13 disease disease NN cord-014516-r59usk02 2004 14 and and CC cord-014516-r59usk02 2004 15 that that WDT cord-014516-r59usk02 2004 16 provide provide VBP cord-014516-r59usk02 2004 17 objective objective JJ cord-014516-r59usk02 2004 18 measures measure NNS cord-014516-r59usk02 2004 19 of of IN cord-014516-r59usk02 2004 20 disease disease NN cord-014516-r59usk02 2004 21 severity severity NN cord-014516-r59usk02 2004 22 , , , cord-014516-r59usk02 2004 23 progression progression NN cord-014516-r59usk02 2004 24 , , , cord-014516-r59usk02 2004 25 and and CC cord-014516-r59usk02 2004 26 prognosis prognosis NN cord-014516-r59usk02 2004 27 . . . cord-014516-r59usk02 2005 1 Serum serum NN cord-014516-r59usk02 2005 2 citrulline citrulline NN cord-014516-r59usk02 2005 3 is be VBZ cord-014516-r59usk02 2005 4 a a DT cord-014516-r59usk02 2005 5 useful useful JJ cord-014516-r59usk02 2005 6 biomarker biomarker NN cord-014516-r59usk02 2005 7 in in IN cord-014516-r59usk02 2005 8 human human JJ cord-014516-r59usk02 2005 9 intestinal intestinal JJ cord-014516-r59usk02 2005 10 disease disease NN cord-014516-r59usk02 2005 11 as as IN cord-014516-r59usk02 2005 12 it -PRON- PRP cord-014516-r59usk02 2005 13 is be VBZ cord-014516-r59usk02 2005 14 specific specific JJ cord-014516-r59usk02 2005 15 to to IN cord-014516-r59usk02 2005 16 the the DT cord-014516-r59usk02 2005 17 small small JJ cord-014516-r59usk02 2005 18 intestine intestine NN cord-014516-r59usk02 2005 19 and and CC cord-014516-r59usk02 2005 20 indicates indicate VBZ cord-014516-r59usk02 2005 21 globally globally RB cord-014516-r59usk02 2005 22 reduced reduce VBN cord-014516-r59usk02 2005 23 enterocyte enterocyte NNP cord-014516-r59usk02 2005 24 mass mass NN cord-014516-r59usk02 2005 25 and and CC cord-014516-r59usk02 2005 26 absorptive absorptive JJ cord-014516-r59usk02 2005 27 function function NN cord-014516-r59usk02 2005 28 in in IN cord-014516-r59usk02 2005 29 various various JJ cord-014516-r59usk02 2005 30 disease disease NN cord-014516-r59usk02 2005 31 states state NNS cord-014516-r59usk02 2005 32 . . . cord-014516-r59usk02 2006 1 It -PRON- PRP cord-014516-r59usk02 2006 2 is be VBZ cord-014516-r59usk02 2006 3 used use VBN cord-014516-r59usk02 2006 4 to to TO cord-014516-r59usk02 2006 5 determine determine VB cord-014516-r59usk02 2006 6 , , , cord-014516-r59usk02 2006 7 quantitatively quantitatively RB cord-014516-r59usk02 2006 8 , , , cord-014516-r59usk02 2006 9 intestinal intestinal JJ cord-014516-r59usk02 2006 10 integrity integrity NN cord-014516-r59usk02 2006 11 at at IN cord-014516-r59usk02 2006 12 the the DT cord-014516-r59usk02 2006 13 enterocyte enterocyte NNP cord-014516-r59usk02 2006 14 level level NN cord-014516-r59usk02 2006 15 and and CC cord-014516-r59usk02 2006 16 is be VBZ cord-014516-r59usk02 2006 17 not not RB cord-014516-r59usk02 2006 18 influenced influence VBN cord-014516-r59usk02 2006 19 by by IN cord-014516-r59usk02 2006 20 nutritional nutritional JJ cord-014516-r59usk02 2006 21 or or CC cord-014516-r59usk02 2006 22 inflammatory inflammatory JJ cord-014516-r59usk02 2006 23 status status NN cord-014516-r59usk02 2006 24 . . . cord-014516-r59usk02 2007 1 The the DT cord-014516-r59usk02 2007 2 aim aim NN cord-014516-r59usk02 2007 3 of of IN cord-014516-r59usk02 2007 4 this this DT cord-014516-r59usk02 2007 5 study study NN cord-014516-r59usk02 2007 6 was be VBD cord-014516-r59usk02 2007 7 to to TO cord-014516-r59usk02 2007 8 determine determine VB cord-014516-r59usk02 2007 9 whether whether IN cord-014516-r59usk02 2007 10 serum serum NN cord-014516-r59usk02 2007 11 citrulline citrulline NN cord-014516-r59usk02 2007 12 can can MD cord-014516-r59usk02 2007 13 be be VB cord-014516-r59usk02 2007 14 used use VBN cord-014516-r59usk02 2007 15 as as IN cord-014516-r59usk02 2007 16 a a DT cord-014516-r59usk02 2007 17 biomarker biomarker NN cord-014516-r59usk02 2007 18 for for IN cord-014516-r59usk02 2007 19 CE CE NNP cord-014516-r59usk02 2007 20 in in IN cord-014516-r59usk02 2007 21 dogs dog NNS cord-014516-r59usk02 2007 22 . . . cord-014516-r59usk02 2008 1 In in IN cord-014516-r59usk02 2008 2 this this DT cord-014516-r59usk02 2008 3 retrospective retrospective JJ cord-014516-r59usk02 2008 4 study study NN cord-014516-r59usk02 2008 5 , , , cord-014516-r59usk02 2008 6 computer computer NN cord-014516-r59usk02 2008 7 records record NNS cord-014516-r59usk02 2008 8 from from IN cord-014516-r59usk02 2008 9 the the DT cord-014516-r59usk02 2008 10 University University NNP cord-014516-r59usk02 2008 11 of of IN cord-014516-r59usk02 2008 12 Liverpool Liverpool NNP cord-014516-r59usk02 2008 13 Small Small NNP cord-014516-r59usk02 2008 14 Animal Animal NNP cord-014516-r59usk02 2008 15 Teaching Teaching NNP cord-014516-r59usk02 2008 16 Hospital Hospital NNP cord-014516-r59usk02 2008 17 were be VBD cord-014516-r59usk02 2008 18 used use VBN cord-014516-r59usk02 2008 19 to to TO cord-014516-r59usk02 2008 20 identify identify VB cord-014516-r59usk02 2008 21 dogs dog NNS cord-014516-r59usk02 2008 22 with with IN cord-014516-r59usk02 2008 23 CE CE NNP cord-014516-r59usk02 2008 24 . . . cord-014516-r59usk02 2009 1 Disease disease NN cord-014516-r59usk02 2009 2 severity severity NN cord-014516-r59usk02 2009 3 was be VBD cord-014516-r59usk02 2009 4 quantified quantify VBN cord-014516-r59usk02 2009 5 by by IN cord-014516-r59usk02 2009 6 CIBDAI CIBDAI NNP cord-014516-r59usk02 2009 7 . . . cord-014516-r59usk02 2010 1 Controls control NNS cord-014516-r59usk02 2010 2 were be VBD cord-014516-r59usk02 2010 3 age age NN cord-014516-r59usk02 2010 4 - - HYPH cord-014516-r59usk02 2010 5 and and CC cord-014516-r59usk02 2010 6 breed breed NN cord-014516-r59usk02 2010 7 - - HYPH cord-014516-r59usk02 2010 8 matched match VBN cord-014516-r59usk02 2010 9 dogs dog NNS cord-014516-r59usk02 2010 10 without without IN cord-014516-r59usk02 2010 11 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2010 12 disease disease NN cord-014516-r59usk02 2010 13 . . . cord-014516-r59usk02 2011 1 Serum serum NN cord-014516-r59usk02 2011 2 citrulline citrulline NN cord-014516-r59usk02 2011 3 was be VBD cord-014516-r59usk02 2011 4 measured measure VBN cord-014516-r59usk02 2011 5 by by IN cord-014516-r59usk02 2011 6 ultra ultra JJ cord-014516-r59usk02 2011 7 - - JJ cord-014516-r59usk02 2011 8 high high JJ cord-014516-r59usk02 2011 9 performance performance NN cord-014516-r59usk02 2011 10 liquid liquid NN cord-014516-r59usk02 2011 11 chromatography chromatography NN cord-014516-r59usk02 2011 12 with with IN cord-014516-r59usk02 2011 13 tandem tandem JJ cord-014516-r59usk02 2011 14 mass mass NN cord-014516-r59usk02 2011 15 spectrometry spectrometry NN cord-014516-r59usk02 2011 16 . . . cord-014516-r59usk02 2012 1 In in IN cord-014516-r59usk02 2012 2 dogs dog NNS cord-014516-r59usk02 2012 3 with with IN cord-014516-r59usk02 2012 4 CE CE NNP cord-014516-r59usk02 2012 5 , , , cord-014516-r59usk02 2012 6 serum serum NN cord-014516-r59usk02 2012 7 citrulline citrulline NN cord-014516-r59usk02 2012 8 concentration concentration NN cord-014516-r59usk02 2012 9 was be VBD cord-014516-r59usk02 2012 10 measured measure VBN cord-014516-r59usk02 2012 11 at at IN cord-014516-r59usk02 2012 12 presentation presentation NN cord-014516-r59usk02 2012 13 and and CC cord-014516-r59usk02 2012 14 at at IN cord-014516-r59usk02 2012 15 various various JJ cord-014516-r59usk02 2012 16 time time NN cord-014516-r59usk02 2012 17 points point NNS cord-014516-r59usk02 2012 18 after after IN cord-014516-r59usk02 2012 19 starting start VBG cord-014516-r59usk02 2012 20 treatment treatment NN cord-014516-r59usk02 2012 21 . . . cord-014516-r59usk02 2013 1 Serum serum NN cord-014516-r59usk02 2013 2 citrulline citrulline NN cord-014516-r59usk02 2013 3 was be VBD cord-014516-r59usk02 2013 4 measured measure VBN cord-014516-r59usk02 2013 5 in in IN cord-014516-r59usk02 2013 6 49 49 CD cord-014516-r59usk02 2013 7 dogs dog NNS cord-014516-r59usk02 2013 8 with with IN cord-014516-r59usk02 2013 9 CE CE NNP cord-014516-r59usk02 2013 10 and and CC cord-014516-r59usk02 2013 11 69 69 CD cord-014516-r59usk02 2013 12 controls control NNS cord-014516-r59usk02 2013 13 . . . cord-014516-r59usk02 2014 1 17 17 CD cord-014516-r59usk02 2014 2 dogs dog NNS cord-014516-r59usk02 2014 3 responded respond VBD cord-014516-r59usk02 2014 4 to to IN cord-014516-r59usk02 2014 5 dietary dietary JJ cord-014516-r59usk02 2014 6 manipulation manipulation NN cord-014516-r59usk02 2014 7 ( ( -LRB- cord-014516-r59usk02 2014 8 food food NN cord-014516-r59usk02 2014 9 - - HYPH cord-014516-r59usk02 2014 10 responsive responsive JJ cord-014516-r59usk02 2014 11 enteropathy enteropathy NNP cord-014516-r59usk02 2014 12 , , , cord-014516-r59usk02 2014 13 FRE FRE NNP cord-014516-r59usk02 2014 14 ) ) -RRB- cord-014516-r59usk02 2014 15 and and CC cord-014516-r59usk02 2014 16 3 3 CD cord-014516-r59usk02 2014 17 responded respond VBD cord-014516-r59usk02 2014 18 to to IN cord-014516-r59usk02 2014 19 antibacterials antibacterial NNS cord-014516-r59usk02 2014 20 ( ( -LRB- cord-014516-r59usk02 2014 21 antibiotic antibiotic JJ cord-014516-r59usk02 2014 22 - - HYPH cord-014516-r59usk02 2014 23 responsive responsive JJ cord-014516-r59usk02 2014 24 diarrhoea diarrhoea NN cord-014516-r59usk02 2014 25 , , , cord-014516-r59usk02 2014 26 ARD ARD NNP cord-014516-r59usk02 2014 27 ) ) -RRB- cord-014516-r59usk02 2014 28 , , , cord-014516-r59usk02 2014 29 with with IN cord-014516-r59usk02 2014 30 a a DT cord-014516-r59usk02 2014 31 further further JJ cord-014516-r59usk02 2014 32 2 2 CD cord-014516-r59usk02 2014 33 having have VBG cord-014516-r59usk02 2014 34 invasive invasive JJ cord-014516-r59usk02 2014 35 mucosal mucosal JJ cord-014516-r59usk02 2014 36 bacteria bacteria NNS cord-014516-r59usk02 2014 37 , , , cord-014516-r59usk02 2014 38 of of IN cord-014516-r59usk02 2014 39 which which WDT cord-014516-r59usk02 2014 40 one one NN cord-014516-r59usk02 2014 41 responded respond VBD cord-014516-r59usk02 2014 42 to to IN cord-014516-r59usk02 2014 43 antibacterials antibacterial NNS cord-014516-r59usk02 2014 44 and and CC cord-014516-r59usk02 2014 45 one one CD cord-014516-r59usk02 2014 46 was be VBD cord-014516-r59usk02 2014 47 refractory refractory JJ cord-014516-r59usk02 2014 48 . . . cord-014516-r59usk02 2015 1 27 27 CD cord-014516-r59usk02 2015 2 dogs dog NNS cord-014516-r59usk02 2015 3 were be VBD cord-014516-r59usk02 2015 4 diagnosed diagnose VBN cord-014516-r59usk02 2015 5 with with IN cord-014516-r59usk02 2015 6 idiopathic idiopathic JJ cord-014516-r59usk02 2015 7 IBD IBD NNP cord-014516-r59usk02 2015 8 ( ( -LRB- cord-014516-r59usk02 2015 9 on on IN cord-014516-r59usk02 2015 10 the the DT cord-014516-r59usk02 2015 11 basis basis NN cord-014516-r59usk02 2015 12 of of IN cord-014516-r59usk02 2015 13 exclusion exclusion NN cord-014516-r59usk02 2015 14 of of IN cord-014516-r59usk02 2015 15 known know VBN cord-014516-r59usk02 2015 16 causes cause NNS cord-014516-r59usk02 2015 17 and and CC cord-014516-r59usk02 2015 18 failure failure NN cord-014516-r59usk02 2015 19 to to TO cord-014516-r59usk02 2015 20 respond respond VB cord-014516-r59usk02 2015 21 to to IN cord-014516-r59usk02 2015 22 therapeutic therapeutic JJ cord-014516-r59usk02 2015 23 dietary dietary JJ cord-014516-r59usk02 2015 24 and and CC cord-014516-r59usk02 2015 25 antibiotic antibiotic JJ cord-014516-r59usk02 2015 26 trials trial NNS cord-014516-r59usk02 2015 27 ) ) -RRB- cord-014516-r59usk02 2015 28 , , , cord-014516-r59usk02 2015 29 of of IN cord-014516-r59usk02 2015 30 which which WDT cord-014516-r59usk02 2015 31 12 12 CD cord-014516-r59usk02 2015 32 responded respond VBD cord-014516-r59usk02 2015 33 to to IN cord-014516-r59usk02 2015 34 immunosuppressive immunosuppressive JJ cord-014516-r59usk02 2015 35 therapy therapy NN cord-014516-r59usk02 2015 36 , , , cord-014516-r59usk02 2015 37 13 13 CD cord-014516-r59usk02 2015 38 were be VBD cord-014516-r59usk02 2015 39 refractory refractory JJ cord-014516-r59usk02 2015 40 , , , cord-014516-r59usk02 2015 41 and and CC cord-014516-r59usk02 2015 42 2 2 CD cord-014516-r59usk02 2015 43 were be VBD cord-014516-r59usk02 2015 44 lost lose VBN cord-014516-r59usk02 2015 45 to to TO cord-014516-r59usk02 2015 46 follow follow VB cord-014516-r59usk02 2015 47 - - HYPH cord-014516-r59usk02 2015 48 up up NN cord-014516-r59usk02 2015 49 . . . cord-014516-r59usk02 2016 1 Serum serum NN cord-014516-r59usk02 2016 2 citrulline citrulline NN cord-014516-r59usk02 2016 3 concentration concentration NN cord-014516-r59usk02 2016 4 did do VBD cord-014516-r59usk02 2016 5 not not RB cord-014516-r59usk02 2016 6 differ differ VB cord-014516-r59usk02 2016 7 between between IN cord-014516-r59usk02 2016 8 dogs dog NNS cord-014516-r59usk02 2016 9 with with IN cord-014516-r59usk02 2016 10 CE CE NNP cord-014516-r59usk02 2016 11 ( ( -LRB- cord-014516-r59usk02 2016 12 median median JJ cord-014516-r59usk02 2016 13 8.5 8.5 CD cord-014516-r59usk02 2016 14 lg lg NNP cord-014516-r59usk02 2016 15 / / SYM cord-014516-r59usk02 2016 16 mL ml NN cord-014516-r59usk02 2016 17 , , , cord-014516-r59usk02 2016 18 range range VBP cord-014516-r59usk02 2016 19 1.4 1.4 CD cord-014516-r59usk02 2016 20 - - SYM cord-014516-r59usk02 2016 21 20.6 20.6 CD cord-014516-r59usk02 2016 22 ) ) -RRB- cord-014516-r59usk02 2016 23 and and CC cord-014516-r59usk02 2016 24 controls control NNS cord-014516-r59usk02 2016 25 ( ( -LRB- cord-014516-r59usk02 2016 26 median median NN cord-014516-r59usk02 2016 27 8.2 8.2 CD cord-014516-r59usk02 2016 28 lg lg NNP cord-014516-r59usk02 2016 29 / / SYM cord-014516-r59usk02 2016 30 mL ml NN cord-014516-r59usk02 2016 31 , , , cord-014516-r59usk02 2016 32 range range NN cord-014516-r59usk02 2016 33 , , , cord-014516-r59usk02 2016 34 1.2 1.2 CD cord-014516-r59usk02 2016 35 - - SYM cord-014516-r59usk02 2016 36 34.9 34.9 CD cord-014516-r59usk02 2016 37 , , , cord-014516-r59usk02 2016 38 P p NN cord-014516-r59usk02 2016 39 = = SYM cord-014516-r59usk02 2016 40 0.96 0.96 CD cord-014516-r59usk02 2016 41 ) ) -RRB- cord-014516-r59usk02 2016 42 . . . cord-014516-r59usk02 2017 1 There there EX cord-014516-r59usk02 2017 2 was be VBD cord-014516-r59usk02 2017 3 also also RB cord-014516-r59usk02 2017 4 no no DT cord-014516-r59usk02 2017 5 difference difference NN cord-014516-r59usk02 2017 6 in in IN cord-014516-r59usk02 2017 7 serum serum NN cord-014516-r59usk02 2017 8 citrulline citrulline NN cord-014516-r59usk02 2017 9 concentration concentration NN cord-014516-r59usk02 2017 10 amongst amongst IN cord-014516-r59usk02 2017 11 dogs dog NNS cord-014516-r59usk02 2017 12 with with IN cord-014516-r59usk02 2017 13 FRE FRE NNP cord-014516-r59usk02 2017 14 , , , cord-014516-r59usk02 2017 15 ARD ARD NNP cord-014516-r59usk02 2017 16 , , , cord-014516-r59usk02 2017 17 IBD IBD NNP cord-014516-r59usk02 2017 18 , , , cord-014516-r59usk02 2017 19 and and CC cord-014516-r59usk02 2017 20 controls control NNS cord-014516-r59usk02 2018 1 ( ( -LRB- cord-014516-r59usk02 2018 2 P p NN cord-014516-r59usk02 2018 3 = = SYM cord-014516-r59usk02 2018 4 0.48 0.48 CD cord-014516-r59usk02 2018 5 ) ) -RRB- cord-014516-r59usk02 2018 6 . . . cord-014516-r59usk02 2019 1 Serum serum NN cord-014516-r59usk02 2019 2 citrulline citrulline NN cord-014516-r59usk02 2019 3 did do VBD cord-014516-r59usk02 2019 4 not not RB cord-014516-r59usk02 2019 5 differ differ VB cord-014516-r59usk02 2019 6 between between IN cord-014516-r59usk02 2019 7 dogs dog NNS cord-014516-r59usk02 2019 8 that that WDT cord-014516-r59usk02 2019 9 responded respond VBD cord-014516-r59usk02 2019 10 well well RB cord-014516-r59usk02 2019 11 , , , cord-014516-r59usk02 2019 12 or or CC cord-014516-r59usk02 2019 13 were be VBD cord-014516-r59usk02 2019 14 refractory refractory JJ cord-014516-r59usk02 2019 15 to to IN cord-014516-r59usk02 2019 16 treatment treatment NN cord-014516-r59usk02 2019 17 ( ( -LRB- cord-014516-r59usk02 2019 18 P p NN cord-014516-r59usk02 2019 19 = = SYM cord-014516-r59usk02 2019 20 0.39 0.39 CD cord-014516-r59usk02 2019 21 ) ) -RRB- cord-014516-r59usk02 2019 22 , , , cord-014516-r59usk02 2019 23 between between IN cord-014516-r59usk02 2019 24 23 23 CD cord-014516-r59usk02 2019 25 dogs dog NNS cord-014516-r59usk02 2019 26 with with IN cord-014516-r59usk02 2019 27 and and CC cord-014516-r59usk02 2019 28 26 26 CD cord-014516-r59usk02 2019 29 without without IN cord-014516-r59usk02 2019 30 protein protein NN cord-014516-r59usk02 2019 31 - - HYPH cord-014516-r59usk02 2019 32 losing lose VBG cord-014516-r59usk02 2019 33 enteropathy enteropathy NNS cord-014516-r59usk02 2019 34 ( ( -LRB- cord-014516-r59usk02 2019 35 P p NN cord-014516-r59usk02 2019 36 = = SYM cord-014516-r59usk02 2019 37 0.67 0.67 CD cord-014516-r59usk02 2019 38 ) ) -RRB- cord-014516-r59usk02 2019 39 , , , cord-014516-r59usk02 2019 40 or or CC cord-014516-r59usk02 2019 41 between between IN cord-014516-r59usk02 2019 42 35 35 CD cord-014516-r59usk02 2019 43 dogs dog NNS cord-014516-r59usk02 2019 44 that that WDT cord-014516-r59usk02 2019 45 survived survive VBD cord-014516-r59usk02 2019 46 and and CC cord-014516-r59usk02 2019 47 8 8 CD cord-014516-r59usk02 2019 48 that that WDT cord-014516-r59usk02 2019 49 were be VBD cord-014516-r59usk02 2019 50 euthanased euthanase VBN cord-014516-r59usk02 2019 51 because because IN cord-014516-r59usk02 2019 52 of of IN cord-014516-r59usk02 2019 53 CE CE NNP cord-014516-r59usk02 2019 54 ( ( -LRB- cord-014516-r59usk02 2019 55 P p NN cord-014516-r59usk02 2019 56 = = SYM cord-014516-r59usk02 2019 57 0.65 0.65 CD cord-014516-r59usk02 2019 58 ) ) -RRB- cord-014516-r59usk02 2019 59 . . . cord-014516-r59usk02 2020 1 Serum serum NN cord-014516-r59usk02 2020 2 citrulline citrulline NN cord-014516-r59usk02 2020 3 did do VBD cord-014516-r59usk02 2020 4 not not RB cord-014516-r59usk02 2020 5 correlate correlate VB cord-014516-r59usk02 2020 6 with with IN cord-014516-r59usk02 2020 7 CIBDAI CIBDAI NNP cord-014516-r59usk02 2021 1 ( ( -LRB- cord-014516-r59usk02 2021 2 r r NN cord-014516-r59usk02 2021 3 2 2 CD cord-014516-r59usk02 2021 4 = = SYM cord-014516-r59usk02 2021 5 0.10 0.10 CD cord-014516-r59usk02 2021 6 ) ) -RRB- cord-014516-r59usk02 2021 7 . . . cord-014516-r59usk02 2022 1 These these DT cord-014516-r59usk02 2022 2 findings finding NNS cord-014516-r59usk02 2022 3 do do VBP cord-014516-r59usk02 2022 4 not not RB cord-014516-r59usk02 2022 5 support support VB cord-014516-r59usk02 2022 6 the the DT cord-014516-r59usk02 2022 7 use use NN cord-014516-r59usk02 2022 8 of of IN cord-014516-r59usk02 2022 9 serum serum NN cord-014516-r59usk02 2022 10 citrulline citrulline NN cord-014516-r59usk02 2022 11 as as IN cord-014516-r59usk02 2022 12 a a DT cord-014516-r59usk02 2022 13 biomarker biomarker NN cord-014516-r59usk02 2022 14 in in IN cord-014516-r59usk02 2022 15 determining determine VBG cord-014516-r59usk02 2022 16 diagnosis diagnosis NN cord-014516-r59usk02 2022 17 , , , cord-014516-r59usk02 2022 18 prognosis prognosis NN cord-014516-r59usk02 2022 19 , , , cord-014516-r59usk02 2022 20 or or CC cord-014516-r59usk02 2022 21 quantifying quantify VBG cord-014516-r59usk02 2022 22 severity severity NN cord-014516-r59usk02 2022 23 in in IN cord-014516-r59usk02 2022 24 dogs dog NNS cord-014516-r59usk02 2022 25 with with IN cord-014516-r59usk02 2022 26 CE CE NNP cord-014516-r59usk02 2022 27 . . . cord-014516-r59usk02 2023 1 One one CD cord-014516-r59usk02 2023 2 of of IN cord-014516-r59usk02 2023 3 the the DT cord-014516-r59usk02 2023 4 co co NNS cord-014516-r59usk02 2023 5 - - NNS cord-014516-r59usk02 2023 6 authors author NNS cord-014516-r59usk02 2023 7 ( ( -LRB- cord-014516-r59usk02 2023 8 Marco Marco NNP cord-014516-r59usk02 2023 9 Caldin Caldin NNP cord-014516-r59usk02 2023 10 ) ) -RRB- cord-014516-r59usk02 2023 11 has have VBZ cord-014516-r59usk02 2023 12 a a DT cord-014516-r59usk02 2023 13 diagnostic diagnostic JJ cord-014516-r59usk02 2023 14 laboratory laboratory NN cord-014516-r59usk02 2023 15 offering offering NN cord-014516-r59usk02 2023 16 citrulline citrulline NN cord-014516-r59usk02 2023 17 assays assay NNS cord-014516-r59usk02 2023 18 . . . cord-014516-r59usk02 2024 1 Chronic chronic JJ cord-014516-r59usk02 2024 2 enteropathy enteropathy NNP cord-014516-r59usk02 2024 3 ( ( -LRB- cord-014516-r59usk02 2024 4 CE CE NNP cord-014516-r59usk02 2024 5 ) ) -RRB- cord-014516-r59usk02 2024 6 is be VBZ cord-014516-r59usk02 2024 7 a a DT cord-014516-r59usk02 2024 8 multi multi JJ cord-014516-r59usk02 2024 9 - - JJ cord-014516-r59usk02 2024 10 factorial factorial JJ cord-014516-r59usk02 2024 11 disease disease NN cord-014516-r59usk02 2024 12 , , , cord-014516-r59usk02 2024 13 which which WDT cord-014516-r59usk02 2024 14 involves involve VBZ cord-014516-r59usk02 2024 15 aberrant aberrant JJ cord-014516-r59usk02 2024 16 immune immune JJ cord-014516-r59usk02 2024 17 responses response NNS cord-014516-r59usk02 2024 18 to to IN cord-014516-r59usk02 2024 19 commensal commensal JJ cord-014516-r59usk02 2024 20 bacteria bacteria NNS cord-014516-r59usk02 2024 21 or or CC cord-014516-r59usk02 2024 22 dietary dietary JJ cord-014516-r59usk02 2024 23 antigens antigen NNS cord-014516-r59usk02 2024 24 . . . cord-014516-r59usk02 2025 1 Macrophages macrophage NNS cord-014516-r59usk02 2025 2 have have VBP cord-014516-r59usk02 2025 3 an an DT cord-014516-r59usk02 2025 4 important important JJ cord-014516-r59usk02 2025 5 role role NN cord-014516-r59usk02 2025 6 in in IN cord-014516-r59usk02 2025 7 human human JJ cord-014516-r59usk02 2025 8 disease disease NN cord-014516-r59usk02 2025 9 but but CC cord-014516-r59usk02 2025 10 little little JJ cord-014516-r59usk02 2025 11 information information NN cord-014516-r59usk02 2025 12 is be VBZ cord-014516-r59usk02 2025 13 available available JJ cord-014516-r59usk02 2025 14 in in IN cord-014516-r59usk02 2025 15 canine canine JJ cord-014516-r59usk02 2025 16 intestine intestine NN cord-014516-r59usk02 2025 17 . . . cord-014516-r59usk02 2026 1 Data datum NNS cord-014516-r59usk02 2026 2 to to IN cord-014516-r59usk02 2026 3 date date NN cord-014516-r59usk02 2026 4 have have VBP cord-014516-r59usk02 2026 5 relied rely VBN cord-014516-r59usk02 2026 6 solely solely RB cord-014516-r59usk02 2026 7 on on IN cord-014516-r59usk02 2026 8 macrophage macrophage NN cord-014516-r59usk02 2026 9 identification identification NN cord-014516-r59usk02 2026 10 using use VBG cord-014516-r59usk02 2026 11 MAC387 MAC387 NNP cord-014516-r59usk02 2026 12 , , , cord-014516-r59usk02 2026 13 an an DT cord-014516-r59usk02 2026 14 antibody antibody NN cord-014516-r59usk02 2026 15 directed direct VBN cord-014516-r59usk02 2026 16 against against IN cord-014516-r59usk02 2026 17 calprotectin calprotectin NNP cord-014516-r59usk02 2026 18 , , , cord-014516-r59usk02 2026 19 which which WDT cord-014516-r59usk02 2026 20 recognizes recognize VBZ cord-014516-r59usk02 2026 21 both both DT cord-014516-r59usk02 2026 22 macrophages macrophage NNS cord-014516-r59usk02 2026 23 and and CC cord-014516-r59usk02 2026 24 neutrophils neutrophil NNS cord-014516-r59usk02 2026 25 . . . cord-014516-r59usk02 2027 1 In in IN cord-014516-r59usk02 2027 2 this this DT cord-014516-r59usk02 2027 3 study study NN cord-014516-r59usk02 2027 4 an an DT cord-014516-r59usk02 2027 5 alternative alternative JJ cord-014516-r59usk02 2027 6 antibody antibody NN cord-014516-r59usk02 2027 7 for for IN cord-014516-r59usk02 2027 8 macrophages macrophage NNS cord-014516-r59usk02 2027 9 , , , cord-014516-r59usk02 2027 10 AM-3 AM-3 NNP cord-014516-r59usk02 2027 11 K K NNP cord-014516-r59usk02 2027 12 , , , cord-014516-r59usk02 2027 13 directed direct VBN cord-014516-r59usk02 2027 14 against against IN cord-014516-r59usk02 2027 15 a a DT cord-014516-r59usk02 2027 16 scavenger scavenger NN cord-014516-r59usk02 2027 17 receptor receptor NN cord-014516-r59usk02 2027 18 ( ( -LRB- cord-014516-r59usk02 2027 19 CD163 CD163 NNP cord-014516-r59usk02 2027 20 ) ) -RRB- cord-014516-r59usk02 2027 21 was be VBD cord-014516-r59usk02 2027 22 used use VBN cord-014516-r59usk02 2027 23 and and CC cord-014516-r59usk02 2027 24 distribution distribution NN cord-014516-r59usk02 2027 25 of of IN cord-014516-r59usk02 2027 26 both both DT cord-014516-r59usk02 2027 27 markers marker NNS cord-014516-r59usk02 2027 28 was be VBD cord-014516-r59usk02 2027 29 compared compare VBN cord-014516-r59usk02 2027 30 . . . cord-014516-r59usk02 2028 1 This this DT cord-014516-r59usk02 2028 2 antigen antigen NN cord-014516-r59usk02 2028 3 is be VBZ cord-014516-r59usk02 2028 4 of of IN cord-014516-r59usk02 2028 5 interest interest NN cord-014516-r59usk02 2028 6 as as IN cord-014516-r59usk02 2028 7 positive positive JJ cord-014516-r59usk02 2028 8 cells cell NNS cord-014516-r59usk02 2028 9 accumulate accumulate VBP cord-014516-r59usk02 2028 10 in in IN cord-014516-r59usk02 2028 11 intestine intestine NN cord-014516-r59usk02 2028 12 of of IN cord-014516-r59usk02 2028 13 humans human NNS cord-014516-r59usk02 2028 14 with with IN cord-014516-r59usk02 2028 15 CE CE NNP cord-014516-r59usk02 2028 16 . . . cord-014516-r59usk02 2029 1 Endoscopic endoscopic JJ cord-014516-r59usk02 2029 2 duodenal duodenal JJ cord-014516-r59usk02 2029 3 biopsies biopsy NNS cord-014516-r59usk02 2029 4 were be VBD cord-014516-r59usk02 2029 5 obtained obtain VBN cord-014516-r59usk02 2029 6 from from IN cord-014516-r59usk02 2029 7 seven seven CD cord-014516-r59usk02 2029 8 crossbreed crossbreed NN cord-014516-r59usk02 2029 9 dogs dog NNS cord-014516-r59usk02 2029 10 . . . cord-014516-r59usk02 2030 1 Serial serial JJ cord-014516-r59usk02 2030 2 histologic histologic JJ cord-014516-r59usk02 2030 3 sections section NNS cord-014516-r59usk02 2030 4 were be VBD cord-014516-r59usk02 2030 5 stained stain VBN cord-014516-r59usk02 2030 6 with with IN cord-014516-r59usk02 2030 7 MAC387 MAC387 NNP cord-014516-r59usk02 2030 8 or or CC cord-014516-r59usk02 2030 9 AM-3K. AM-3K. NNP cord-014516-r59usk02 2030 10 Positively positively RB cord-014516-r59usk02 2030 11 - - HYPH cord-014516-r59usk02 2030 12 stained stain VBN cord-014516-r59usk02 2030 13 cells cell NNS cord-014516-r59usk02 2030 14 were be VBD cord-014516-r59usk02 2030 15 counted count VBN cord-014516-r59usk02 2030 16 from from IN cord-014516-r59usk02 2030 17 5 5 CD cord-014516-r59usk02 2030 18 random random JJ cord-014516-r59usk02 2030 19 areas area NNS cord-014516-r59usk02 2030 20 from from IN cord-014516-r59usk02 2030 21 both both DT cord-014516-r59usk02 2030 22 villous villous NN cord-014516-r59usk02 2030 23 and and CC cord-014516-r59usk02 2030 24 crypt crypt NN cord-014516-r59usk02 2030 25 regions region NNS cord-014516-r59usk02 2030 26 . . . cord-014516-r59usk02 2031 1 Stained stained JJ cord-014516-r59usk02 2031 2 cell cell NN cord-014516-r59usk02 2031 3 localisation localisation NN cord-014516-r59usk02 2031 4 was be VBD cord-014516-r59usk02 2031 5 subjectively subjectively RB cord-014516-r59usk02 2031 6 evaluated evaluate VBN cord-014516-r59usk02 2031 7 and and CC cord-014516-r59usk02 2031 8 the the DT cord-014516-r59usk02 2031 9 percentage percentage NN cord-014516-r59usk02 2031 10 of of IN cord-014516-r59usk02 2031 11 positively positively RB cord-014516-r59usk02 2031 12 stained stain VBN cord-014516-r59usk02 2031 13 cells cell NNS cord-014516-r59usk02 2031 14 from from IN cord-014516-r59usk02 2031 15 the the DT cord-014516-r59usk02 2031 16 total total JJ cord-014516-r59usk02 2031 17 nucleated nucleated JJ cord-014516-r59usk02 2031 18 cells cell NNS cord-014516-r59usk02 2031 19 per per IN cord-014516-r59usk02 2031 20 10,000 10,000 CD cord-014516-r59usk02 2031 21 lm lm NNP cord-014516-r59usk02 2031 22 2 2 CD cord-014516-r59usk02 2031 23 in in IN cord-014516-r59usk02 2031 24 the the DT cord-014516-r59usk02 2031 25 villus villus NN cord-014516-r59usk02 2031 26 or or CC cord-014516-r59usk02 2031 27 crypt crypt NN cord-014516-r59usk02 2031 28 was be VBD cord-014516-r59usk02 2031 29 compared compare VBN cord-014516-r59usk02 2031 30 between between IN cord-014516-r59usk02 2031 31 both both DT cord-014516-r59usk02 2031 32 antibodies antibody NNS cord-014516-r59usk02 2031 33 using use VBG cord-014516-r59usk02 2031 34 a a DT cord-014516-r59usk02 2031 35 Wilcoxon Wilcoxon NNP cord-014516-r59usk02 2031 36 signed sign VBN cord-014516-r59usk02 2031 37 - - HYPH cord-014516-r59usk02 2031 38 rank rank NN cord-014516-r59usk02 2031 39 test test NN cord-014516-r59usk02 2031 40 . . . cord-014516-r59usk02 2032 1 MAC387 MAC387 NNP cord-014516-r59usk02 2032 2 and and CC cord-014516-r59usk02 2032 3 AM-3 AM-3 NNP cord-014516-r59usk02 2032 4 K K NNP cord-014516-r59usk02 2032 5 did do VBD cord-014516-r59usk02 2032 6 not not RB cord-014516-r59usk02 2032 7 co co VB cord-014516-r59usk02 2032 8 - - VB cord-014516-r59usk02 2032 9 localize localize VB cord-014516-r59usk02 2032 10 on on IN cord-014516-r59usk02 2032 11 serial serial JJ cord-014516-r59usk02 2032 12 sections section NNS cord-014516-r59usk02 2032 13 . . . cord-014516-r59usk02 2033 1 There there EX cord-014516-r59usk02 2033 2 were be VBD cord-014516-r59usk02 2033 3 significantly significantly RB cord-014516-r59usk02 2033 4 more more JJR cord-014516-r59usk02 2033 5 AM-3 AM-3 NNP cord-014516-r59usk02 2033 6 K K NNP cord-014516-r59usk02 2033 7 positive positive JJ cord-014516-r59usk02 2033 8 cells cell NNS cord-014516-r59usk02 2033 9 than than IN cord-014516-r59usk02 2033 10 MAC387 MAC387 NNP cord-014516-r59usk02 2033 11 in in IN cord-014516-r59usk02 2033 12 the the DT cord-014516-r59usk02 2033 13 crypts crypt NNS cord-014516-r59usk02 2033 14 ( ( -LRB- cord-014516-r59usk02 2033 15 3.6 3.6 CD cord-014516-r59usk02 2033 16 % % NN cord-014516-r59usk02 2033 17 [ [ -LRB- cord-014516-r59usk02 2033 18 0 0 CD cord-014516-r59usk02 2033 19 - - HYPH cord-014516-r59usk02 2033 20 7.0 7.0 CD cord-014516-r59usk02 2033 21 ] ] -RRB- cord-014516-r59usk02 2033 22 versus versus IN cord-014516-r59usk02 2033 23 0.8 0.8 CD cord-014516-r59usk02 2033 24 % % NN cord-014516-r59usk02 2033 25 [ [ -LRB- cord-014516-r59usk02 2033 26 0 0 CD cord-014516-r59usk02 2033 27 - - HYPH cord-014516-r59usk02 2033 28 7.5 7.5 CD cord-014516-r59usk02 2033 29 ] ] -RRB- cord-014516-r59usk02 2033 30 , , , cord-014516-r59usk02 2033 31 P p NN cord-014516-r59usk02 2033 32 = = SYM cord-014516-r59usk02 2033 33 0.005 0.005 CD cord-014516-r59usk02 2033 34 ) ) -RRB- cord-014516-r59usk02 2033 35 . . . cord-014516-r59usk02 2034 1 In in IN cord-014516-r59usk02 2034 2 contrast contrast NN cord-014516-r59usk02 2034 3 there there EX cord-014516-r59usk02 2034 4 was be VBD cord-014516-r59usk02 2034 5 no no DT cord-014516-r59usk02 2034 6 difference difference NN cord-014516-r59usk02 2034 7 in in IN cord-014516-r59usk02 2034 8 expression expression NN cord-014516-r59usk02 2034 9 of of IN cord-014516-r59usk02 2034 10 either either DT cord-014516-r59usk02 2034 11 markers marker NNS cord-014516-r59usk02 2034 12 in in IN cord-014516-r59usk02 2034 13 the the DT cord-014516-r59usk02 2034 14 villi villi NN cord-014516-r59usk02 2034 15 ( ( -LRB- cord-014516-r59usk02 2034 16 3.2 3.2 CD cord-014516-r59usk02 2034 17 % % NN cord-014516-r59usk02 2034 18 [ [ -LRB- cord-014516-r59usk02 2034 19 0 0 CD cord-014516-r59usk02 2034 20 - - HYPH cord-014516-r59usk02 2034 21 8.16 8.16 CD cord-014516-r59usk02 2034 22 ] ] -RRB- cord-014516-r59usk02 2034 23 versus versus IN cord-014516-r59usk02 2034 24 1.8 1.8 CD cord-014516-r59usk02 2034 25 % % NN cord-014516-r59usk02 2034 26 [ [ -LRB- cord-014516-r59usk02 2034 27 0 0 CD cord-014516-r59usk02 2034 28 - - SYM cord-014516-r59usk02 2034 29 11.2 11.2 CD cord-014516-r59usk02 2034 30 ] ] -RRB- cord-014516-r59usk02 2034 31 , , , cord-014516-r59usk02 2034 32 P p NN cord-014516-r59usk02 2034 33 = = SYM cord-014516-r59usk02 2034 34 0.27 0.27 CD cord-014516-r59usk02 2034 35 ) ) -RRB- cord-014516-r59usk02 2034 36 . . . cord-014516-r59usk02 2035 1 This this DT cord-014516-r59usk02 2035 2 study study NN cord-014516-r59usk02 2035 3 reports report VBZ cord-014516-r59usk02 2035 4 for for IN cord-014516-r59usk02 2035 5 the the DT cord-014516-r59usk02 2035 6 first first JJ cord-014516-r59usk02 2035 7 time time NN cord-014516-r59usk02 2035 8 the the DT cord-014516-r59usk02 2035 9 existence existence NN cord-014516-r59usk02 2035 10 of of IN cord-014516-r59usk02 2035 11 two two CD cord-014516-r59usk02 2035 12 populations population NNS cord-014516-r59usk02 2035 13 of of IN cord-014516-r59usk02 2035 14 macrophages macrophage NNS cord-014516-r59usk02 2035 15 in in IN cord-014516-r59usk02 2035 16 canine canine JJ cord-014516-r59usk02 2035 17 intestine intestine NN cord-014516-r59usk02 2035 18 . . . cord-014516-r59usk02 2036 1 These these DT cord-014516-r59usk02 2036 2 results result NNS cord-014516-r59usk02 2036 3 in in IN cord-014516-r59usk02 2036 4 normal normal JJ cord-014516-r59usk02 2036 5 dogs dog NNS cord-014516-r59usk02 2036 6 will will MD cord-014516-r59usk02 2036 7 be be VB cord-014516-r59usk02 2036 8 used use VBN cord-014516-r59usk02 2036 9 to to TO cord-014516-r59usk02 2036 10 explore explore VB cord-014516-r59usk02 2036 11 further further RB cord-014516-r59usk02 2036 12 the the DT cord-014516-r59usk02 2036 13 distribution distribution NN cord-014516-r59usk02 2036 14 and and CC cord-014516-r59usk02 2036 15 function function NN cord-014516-r59usk02 2036 16 of of IN cord-014516-r59usk02 2036 17 macrophages macrophage NNS cord-014516-r59usk02 2036 18 in in IN cord-014516-r59usk02 2036 19 dogs dog NNS cord-014516-r59usk02 2036 20 with with IN cord-014516-r59usk02 2036 21 CE CE NNP cord-014516-r59usk02 2036 22 . . . cord-014516-r59usk02 2037 1 No no DT cord-014516-r59usk02 2037 2 conflicts conflict NNS cord-014516-r59usk02 2037 3 of of IN cord-014516-r59usk02 2037 4 interest interest NN cord-014516-r59usk02 2037 5 reported report VBN cord-014516-r59usk02 2037 6 . . . cord-014516-r59usk02 2038 1 Chronic chronic JJ cord-014516-r59usk02 2038 2 diarrhea diarrhea NN cord-014516-r59usk02 2038 3 and and CC cord-014516-r59usk02 2038 4 vomiting vomiting NN cord-014516-r59usk02 2038 5 are be VBP cord-014516-r59usk02 2038 6 common common JJ cord-014516-r59usk02 2038 7 clinical clinical JJ cord-014516-r59usk02 2038 8 signs sign NNS cord-014516-r59usk02 2038 9 in in IN cord-014516-r59usk02 2038 10 dogs dog NNS cord-014516-r59usk02 2038 11 . . . cord-014516-r59usk02 2039 1 Primary primary JJ cord-014516-r59usk02 2039 2 ( ( -LRB- cord-014516-r59usk02 2039 3 e.g. e.g. RB cord-014516-r59usk02 2039 4 , , , cord-014516-r59usk02 2039 5 inflammatory inflammatory JJ cord-014516-r59usk02 2039 6 , , , cord-014516-r59usk02 2039 7 infectious infectious JJ cord-014516-r59usk02 2039 8 , , , cord-014516-r59usk02 2039 9 neoplastic neoplastic JJ cord-014516-r59usk02 2039 10 , , , cord-014516-r59usk02 2039 11 mechanical mechanical JJ cord-014516-r59usk02 2039 12 , , , cord-014516-r59usk02 2039 13 or or CC cord-014516-r59usk02 2039 14 other other JJ cord-014516-r59usk02 2039 15 ) ) -RRB- cord-014516-r59usk02 2039 16 and and CC cord-014516-r59usk02 2039 17 secondary secondary JJ cord-014516-r59usk02 2039 18 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2039 19 diseases disease NNS cord-014516-r59usk02 2039 20 ( ( -LRB- cord-014516-r59usk02 2039 21 e.g. e.g. RB cord-014516-r59usk02 2039 22 , , , cord-014516-r59usk02 2039 23 exocrine exocrine JJ cord-014516-r59usk02 2039 24 pancreatic pancreatic NN cord-014516-r59usk02 2039 25 , , , cord-014516-r59usk02 2039 26 hepatic hepatic JJ cord-014516-r59usk02 2039 27 , , , cord-014516-r59usk02 2039 28 renal renal JJ cord-014516-r59usk02 2039 29 , , , cord-014516-r59usk02 2039 30 or or CC cord-014516-r59usk02 2039 31 endocrine endocrine JJ cord-014516-r59usk02 2039 32 disease disease NN cord-014516-r59usk02 2039 33 ) ) -RRB- cord-014516-r59usk02 2039 34 are be VBP cord-014516-r59usk02 2039 35 possible possible JJ cord-014516-r59usk02 2039 36 underlying underlie VBG cord-014516-r59usk02 2039 37 causes cause NNS cord-014516-r59usk02 2039 38 . . . cord-014516-r59usk02 2040 1 The the DT cord-014516-r59usk02 2040 2 aim aim NN cord-014516-r59usk02 2040 3 of of IN cord-014516-r59usk02 2040 4 this this DT cord-014516-r59usk02 2040 5 study study NN cord-014516-r59usk02 2040 6 was be VBD cord-014516-r59usk02 2040 7 to to TO cord-014516-r59usk02 2040 8 evaluate evaluate VB cord-014516-r59usk02 2040 9 the the DT cord-014516-r59usk02 2040 10 final final JJ cord-014516-r59usk02 2040 11 diagnoses diagnosis NNS cord-014516-r59usk02 2040 12 in in IN cord-014516-r59usk02 2040 13 dogs dog NNS cord-014516-r59usk02 2040 14 with with IN cord-014516-r59usk02 2040 15 chronic chronic JJ cord-014516-r59usk02 2040 16 diarrhea diarrhea NN cord-014516-r59usk02 2040 17 and/or and/or CC cord-014516-r59usk02 2040 18 vomiting vomit VBG cord-014516-r59usk02 2040 19 and and CC cord-014516-r59usk02 2040 20 to to TO cord-014516-r59usk02 2040 21 determine determine VB cord-014516-r59usk02 2040 22 the the DT cord-014516-r59usk02 2040 23 prevalence prevalence NN cord-014516-r59usk02 2040 24 of of IN cord-014516-r59usk02 2040 25 various various JJ cord-014516-r59usk02 2040 26 primary primary JJ cord-014516-r59usk02 2040 27 and and CC cord-014516-r59usk02 2040 28 secondary secondary JJ cord-014516-r59usk02 2040 29 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2040 30 diseases disease NNS cord-014516-r59usk02 2040 31 in in IN cord-014516-r59usk02 2040 32 dogs dog NNS cord-014516-r59usk02 2040 33 with with IN cord-014516-r59usk02 2040 34 these these DT cord-014516-r59usk02 2040 35 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2040 36 signs sign NNS cord-014516-r59usk02 2040 37 . . . cord-014516-r59usk02 2041 1 Medical medical JJ cord-014516-r59usk02 2041 2 records record NNS cord-014516-r59usk02 2041 3 of of IN cord-014516-r59usk02 2041 4 209 209 CD cord-014516-r59usk02 2041 5 dogs dog NNS cord-014516-r59usk02 2041 6 presented present VBN cord-014516-r59usk02 2041 7 between between IN cord-014516-r59usk02 2041 8 July July NNP cord-014516-r59usk02 2041 9 2011 2011 CD cord-014516-r59usk02 2041 10 and and CC cord-014516-r59usk02 2041 11 August August NNP cord-014516-r59usk02 2041 12 2013 2013 CD cord-014516-r59usk02 2041 13 with with IN cord-014516-r59usk02 2041 14 chronic chronic JJ cord-014516-r59usk02 2041 15 diarrhea diarrhea NN cord-014516-r59usk02 2041 16 ( ( -LRB- cord-014516-r59usk02 2041 17 D D NNP cord-014516-r59usk02 2041 18 ) ) -RRB- cord-014516-r59usk02 2041 19 , , , cord-014516-r59usk02 2041 20 vomiting vomit VBG cord-014516-r59usk02 2041 21 ( ( -LRB- cord-014516-r59usk02 2041 22 V v NN cord-014516-r59usk02 2041 23 ) ) -RRB- cord-014516-r59usk02 2041 24 or or CC cord-014516-r59usk02 2041 25 both both DT cord-014516-r59usk02 2041 26 ( ( -LRB- cord-014516-r59usk02 2041 27 diarrhea diarrhea NN cord-014516-r59usk02 2041 28 and and CC cord-014516-r59usk02 2041 29 vomiting vomit VBG cord-014516-r59usk02 2041 30 [ [ -LRB- cord-014516-r59usk02 2041 31 VD VD NNP cord-014516-r59usk02 2041 32 ] ] -RRB- cord-014516-r59usk02 2041 33 ) ) -RRB- cord-014516-r59usk02 2041 34 were be VBD cord-014516-r59usk02 2041 35 retrospectively retrospectively RB cord-014516-r59usk02 2041 36 reviewed review VBN cord-014516-r59usk02 2041 37 . . . cord-014516-r59usk02 2042 1 Dogs dog NNS cord-014516-r59usk02 2042 2 were be VBD cord-014516-r59usk02 2042 3 included include VBN cord-014516-r59usk02 2042 4 if if IN cord-014516-r59usk02 2042 5 a a DT cord-014516-r59usk02 2042 6 minimum minimum JJ cord-014516-r59usk02 2042 7 work work NN cord-014516-r59usk02 2042 8 - - HYPH cord-014516-r59usk02 2042 9 up up NN cord-014516-r59usk02 2042 10 ( ( -LRB- cord-014516-r59usk02 2042 11 hematology hematology NN cord-014516-r59usk02 2042 12 , , , cord-014516-r59usk02 2042 13 plasma plasma NN cord-014516-r59usk02 2042 14 biochemistry biochemistry NN cord-014516-r59usk02 2042 15 profile profile NN cord-014516-r59usk02 2042 16 , , , cord-014516-r59usk02 2042 17 and and CC cord-014516-r59usk02 2042 18 fecal fecal JJ cord-014516-r59usk02 2042 19 parasitology parasitology NN cord-014516-r59usk02 2042 20 ) ) -RRB- cord-014516-r59usk02 2042 21 had have VBD cord-014516-r59usk02 2042 22 been be VBN cord-014516-r59usk02 2042 23 performed perform VBN cord-014516-r59usk02 2042 24 and and CC cord-014516-r59usk02 2042 25 if if IN cord-014516-r59usk02 2042 26 a a DT cord-014516-r59usk02 2042 27 final final JJ cord-014516-r59usk02 2042 28 diagnosis diagnosis NN cord-014516-r59usk02 2042 29 was be VBD cord-014516-r59usk02 2042 30 recorded record VBN cord-014516-r59usk02 2042 31 ( ( -LRB- cord-014516-r59usk02 2042 32 155/209 155/209 CD cord-014516-r59usk02 2042 33 ) ) -RRB- cord-014516-r59usk02 2042 34 . . . cord-014516-r59usk02 2043 1 A a DT cord-014516-r59usk02 2043 2 primary primary JJ cord-014516-r59usk02 2043 3 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2043 4 disease disease NN cord-014516-r59usk02 2043 5 was be VBD cord-014516-r59usk02 2043 6 recorded record VBN cord-014516-r59usk02 2043 7 in in IN cord-014516-r59usk02 2043 8 83 83 CD cord-014516-r59usk02 2043 9 % % NN cord-014516-r59usk02 2043 10 of of IN cord-014516-r59usk02 2043 11 the the DT cord-014516-r59usk02 2043 12 cases case NNS cord-014516-r59usk02 2043 13 ( ( -LRB- cord-014516-r59usk02 2043 14 129/155 129/155 CD cord-014516-r59usk02 2043 15 ) ) -RRB- cord-014516-r59usk02 2043 16 and and CC cord-014516-r59usk02 2043 17 included include VBD cord-014516-r59usk02 2043 18 inflammatory inflammatory JJ cord-014516-r59usk02 2043 19 diseases disease NNS cord-014516-r59usk02 2043 20 ( ( -LRB- cord-014516-r59usk02 2043 21 90/ 90/ CD cord-014516-r59usk02 2043 22 , , , cord-014516-r59usk02 2043 23 exocrine exocrine JJ cord-014516-r59usk02 2043 24 pancreatic pancreatic JJ cord-014516-r59usk02 2043 25 insufficiency insufficiency NN cord-014516-r59usk02 2043 26 , , , cord-014516-r59usk02 2043 27 hypoadrenocorticism hypoadrenocorticism NN cord-014516-r59usk02 2043 28 , , , cord-014516-r59usk02 2043 29 polyendocrinopathy polyendocrinopathy NNP cord-014516-r59usk02 2043 30 , , , cord-014516-r59usk02 2043 31 dilated dilated JJ cord-014516-r59usk02 2043 32 cardiomyopathy cardiomyopathy NN cord-014516-r59usk02 2043 33 , , , cord-014516-r59usk02 2043 34 and and CC cord-014516-r59usk02 2043 35 leukemia leukemia NN cord-014516-r59usk02 2043 36 in in IN cord-014516-r59usk02 2043 37 one one CD cord-014516-r59usk02 2043 38 dog dog NN cord-014516-r59usk02 2043 39 each each DT cord-014516-r59usk02 2043 40 ) ) -RRB- cord-014516-r59usk02 2043 41 . . . cord-014516-r59usk02 2044 1 In in IN cord-014516-r59usk02 2044 2 total total NN cord-014516-r59usk02 2044 3 , , , cord-014516-r59usk02 2044 4 44 44 CD cord-014516-r59usk02 2044 5 % % NN cord-014516-r59usk02 2044 6 of of IN cord-014516-r59usk02 2044 7 the the DT cord-014516-r59usk02 2044 8 dogs dog NNS cord-014516-r59usk02 2044 9 were be VBD cord-014516-r59usk02 2044 10 presented present VBN cord-014516-r59usk02 2044 11 with with IN cord-014516-r59usk02 2044 12 D D NNP cord-014516-r59usk02 2044 13 ( ( -LRB- cord-014516-r59usk02 2044 14 69/155 69/155 CD cord-014516-r59usk02 2044 15 ) ) -RRB- cord-014516-r59usk02 2044 16 followed follow VBN cord-014516-r59usk02 2044 17 by by IN cord-014516-r59usk02 2044 18 33 33 CD cord-014516-r59usk02 2044 19 % % NN cord-014516-r59usk02 2044 20 with with IN cord-014516-r59usk02 2044 21 VD VD NNP cord-014516-r59usk02 2044 22 ( ( -LRB- cord-014516-r59usk02 2044 23 51/155 51/155 CD cord-014516-r59usk02 2044 24 ) ) -RRB- cord-014516-r59usk02 2044 25 , , , cord-014516-r59usk02 2044 26 and and CC cord-014516-r59usk02 2044 27 23 23 CD cord-014516-r59usk02 2044 28 % % NN cord-014516-r59usk02 2044 29 with with IN cord-014516-r59usk02 2044 30 V V NNP cord-014516-r59usk02 2044 31 ( ( -LRB- cord-014516-r59usk02 2044 32 35/155 35/155 CD cord-014516-r59usk02 2044 33 ) ) -RRB- cord-014516-r59usk02 2044 34 . . . cord-014516-r59usk02 2045 1 D D NNP cord-014516-r59usk02 2045 2 and and CC cord-014516-r59usk02 2045 3 VD VD NNP cord-014516-r59usk02 2045 4 were be VBD cord-014516-r59usk02 2045 5 significantly significantly RB cord-014516-r59usk02 2045 6 more more RBR cord-014516-r59usk02 2045 7 frequent frequent JJ cord-014516-r59usk02 2045 8 in in IN cord-014516-r59usk02 2045 9 dogs dog NNS cord-014516-r59usk02 2045 10 with with IN cord-014516-r59usk02 2045 11 primary primary JJ cord-014516-r59usk02 2045 12 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2045 13 disease disease NN cord-014516-r59usk02 2045 14 ( ( -LRB- cord-014516-r59usk02 2045 15 D d NN cord-014516-r59usk02 2045 16 : : : cord-014516-r59usk02 2045 17 61/129 61/129 CD cord-014516-r59usk02 2045 18 , , , cord-014516-r59usk02 2045 19 VD VD NNP cord-014516-r59usk02 2045 20 : : : cord-014516-r59usk02 2045 21 46/129 46/129 CD cord-014516-r59usk02 2045 22 ) ) -RRB- cord-014516-r59usk02 2045 23 , , , cord-014516-r59usk02 2045 24 compared compare VBN cord-014516-r59usk02 2045 25 to to IN cord-014516-r59usk02 2045 26 dogs dog NNS cord-014516-r59usk02 2045 27 with with IN cord-014516-r59usk02 2045 28 secondary secondary JJ cord-014516-r59usk02 2045 29 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2045 30 disease disease NN cord-014516-r59usk02 2045 31 ( ( -LRB- cord-014516-r59usk02 2045 32 D D NNP cord-014516-r59usk02 2045 33 : : : cord-014516-r59usk02 2045 34 8/26 8/26 CD cord-014516-r59usk02 2045 35 ; ; : cord-014516-r59usk02 2045 36 VD vd NN cord-014516-r59usk02 2045 37 : : : cord-014516-r59usk02 2045 38 5/26 5/26 CD cord-014516-r59usk02 2045 39 ; ; : cord-014516-r59usk02 2045 40 p p NN cord-014516-r59usk02 2045 41 = = SYM cord-014516-r59usk02 2045 42 0.001 0.001 CD cord-014516-r59usk02 2045 43 , , , cord-014516-r59usk02 2045 44 Chi Chi NNP cord-014516-r59usk02 2045 45 square square JJ cord-014516-r59usk02 2045 46 test test NN cord-014516-r59usk02 2045 47 ) ) -RRB- cord-014516-r59usk02 2045 48 . . . cord-014516-r59usk02 2046 1 V V NNP cord-014516-r59usk02 2046 2 was be VBD cord-014516-r59usk02 2046 3 significantly significantly RB cord-014516-r59usk02 2046 4 more more RBR cord-014516-r59usk02 2046 5 common common JJ cord-014516-r59usk02 2046 6 in in IN cord-014516-r59usk02 2046 7 dogs dog NNS cord-014516-r59usk02 2046 8 with with IN cord-014516-r59usk02 2046 9 secondary secondary JJ cord-014516-r59usk02 2046 10 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2046 11 disease disease NN cord-014516-r59usk02 2046 12 ( ( -LRB- cord-014516-r59usk02 2046 13 13/26 13/26 CD cord-014516-r59usk02 2046 14 ) ) -RRB- cord-014516-r59usk02 2046 15 as as IN cord-014516-r59usk02 2046 16 compared compare VBN cord-014516-r59usk02 2046 17 to to IN cord-014516-r59usk02 2046 18 dogs dog NNS cord-014516-r59usk02 2046 19 with with IN cord-014516-r59usk02 2046 20 primary primary JJ cord-014516-r59usk02 2046 21 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2046 22 disease disease NN cord-014516-r59usk02 2046 23 ( ( -LRB- cord-014516-r59usk02 2046 24 22/129 22/129 CD cord-014516-r59usk02 2046 25 ; ; : cord-014516-r59usk02 2046 26 p p NN cord-014516-r59usk02 2046 27 = = SYM cord-014516-r59usk02 2046 28 0.001 0.001 CD cord-014516-r59usk02 2046 29 ) ) -RRB- cord-014516-r59usk02 2046 30 . . . cord-014516-r59usk02 2047 1 In in IN cord-014516-r59usk02 2047 2 this this DT cord-014516-r59usk02 2047 3 study study NN cord-014516-r59usk02 2047 4 , , , cord-014516-r59usk02 2047 5 food food NN cord-014516-r59usk02 2047 6 responsive responsive JJ cord-014516-r59usk02 2047 7 enteropathy enteropathy NNP cord-014516-r59usk02 2047 8 ( ( -LRB- cord-014516-r59usk02 2047 9 36 36 CD cord-014516-r59usk02 2047 10 % % NN cord-014516-r59usk02 2047 11 ) ) -RRB- cord-014516-r59usk02 2047 12 was be VBD cord-014516-r59usk02 2047 13 the the DT cord-014516-r59usk02 2047 14 most most RBS cord-014516-r59usk02 2047 15 commonly commonly RB cord-014516-r59usk02 2047 16 diagnosed diagnose VBN cord-014516-r59usk02 2047 17 cause cause NN cord-014516-r59usk02 2047 18 of of IN cord-014516-r59usk02 2047 19 chronic chronic JJ cord-014516-r59usk02 2047 20 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2047 21 signs sign NNS cord-014516-r59usk02 2047 22 . . . cord-014516-r59usk02 2048 1 Chronic chronic JJ cord-014516-r59usk02 2048 2 pancreatitis pancreatitis NN cord-014516-r59usk02 2048 3 was be VBD cord-014516-r59usk02 2048 4 the the DT cord-014516-r59usk02 2048 5 most most RBS cord-014516-r59usk02 2048 6 frequent frequent JJ cord-014516-r59usk02 2048 7 cause cause NN cord-014516-r59usk02 2048 8 of of IN cord-014516-r59usk02 2048 9 secondary secondary JJ cord-014516-r59usk02 2048 10 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2048 11 disease disease NN cord-014516-r59usk02 2048 12 ( ( -LRB- cord-014516-r59usk02 2048 13 46 46 CD cord-014516-r59usk02 2048 14 % % NN cord-014516-r59usk02 2048 15 ) ) -RRB- cord-014516-r59usk02 2048 16 . . . cord-014516-r59usk02 2049 1 Diarrhea diarrhea NN cord-014516-r59usk02 2049 2 was be VBD cord-014516-r59usk02 2049 3 significantly significantly RB cord-014516-r59usk02 2049 4 associated associate VBN cord-014516-r59usk02 2049 5 with with IN cord-014516-r59usk02 2049 6 primary primary JJ cord-014516-r59usk02 2049 7 and and CC cord-014516-r59usk02 2049 8 vomiting vomit VBG cord-014516-r59usk02 2049 9 with with IN cord-014516-r59usk02 2049 10 secondary secondary JJ cord-014516-r59usk02 2049 11 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2049 12 disease disease NN cord-014516-r59usk02 2049 13 . . . cord-014516-r59usk02 2050 1 No no DT cord-014516-r59usk02 2050 2 conflicts conflict NNS cord-014516-r59usk02 2050 3 of of IN cord-014516-r59usk02 2050 4 interest interest NN cord-014516-r59usk02 2050 5 reported report VBN cord-014516-r59usk02 2050 6 . . . cord-014516-r59usk02 2051 1 Matrix matrix NN cord-014516-r59usk02 2051 2 metalloproteinases metalloproteinase NNS cord-014516-r59usk02 2051 3 ( ( -LRB- cord-014516-r59usk02 2051 4 MMPs MMPs NNP cord-014516-r59usk02 2051 5 ) ) -RRB- cord-014516-r59usk02 2051 6 2 2 CD cord-014516-r59usk02 2051 7 and and CC cord-014516-r59usk02 2051 8 9 9 CD cord-014516-r59usk02 2051 9 are be VBP cord-014516-r59usk02 2051 10 zinc zinc NN cord-014516-r59usk02 2051 11 - - HYPH cord-014516-r59usk02 2051 12 dependent dependent JJ cord-014516-r59usk02 2051 13 endopeptidases endopeptidase NNS cord-014516-r59usk02 2051 14 that that WDT cord-014516-r59usk02 2051 15 contribute contribute VBP cord-014516-r59usk02 2051 16 to to IN cord-014516-r59usk02 2051 17 the the DT cord-014516-r59usk02 2051 18 control control NN cord-014516-r59usk02 2051 19 of of IN cord-014516-r59usk02 2051 20 breakdown breakdown NN cord-014516-r59usk02 2051 21 and and CC cord-014516-r59usk02 2051 22 reconstitution reconstitution NN cord-014516-r59usk02 2051 23 of of IN cord-014516-r59usk02 2051 24 extracellular extracellular JJ cord-014516-r59usk02 2051 25 matrix matrix NN cord-014516-r59usk02 2051 26 under under IN cord-014516-r59usk02 2051 27 both both CC cord-014516-r59usk02 2051 28 normal normal JJ cord-014516-r59usk02 2051 29 and and CC cord-014516-r59usk02 2051 30 pathological pathological JJ cord-014516-r59usk02 2051 31 conditions condition NNS cord-014516-r59usk02 2051 32 . . . cord-014516-r59usk02 2052 1 Intestinal intestinal JJ cord-014516-r59usk02 2052 2 mucosal mucosal JJ cord-014516-r59usk02 2052 3 levels level NNS cord-014516-r59usk02 2052 4 of of IN cord-014516-r59usk02 2052 5 MMP-2 MMP-2 NNP cord-014516-r59usk02 2052 6 and and CC cord-014516-r59usk02 2052 7 -9 -9 NNP cord-014516-r59usk02 2052 8 have have VBP cord-014516-r59usk02 2052 9 been be VBN cord-014516-r59usk02 2052 10 shown show VBN cord-014516-r59usk02 2052 11 to to TO cord-014516-r59usk02 2052 12 be be VB cord-014516-r59usk02 2052 13 increased increase VBN cord-014516-r59usk02 2052 14 in in IN cord-014516-r59usk02 2052 15 animal animal NN cord-014516-r59usk02 2052 16 models model NNS cord-014516-r59usk02 2052 17 and and CC cord-014516-r59usk02 2052 18 human human JJ cord-014516-r59usk02 2052 19 IBD IBD NNP cord-014516-r59usk02 2052 20 . . . cord-014516-r59usk02 2053 1 To to IN cord-014516-r59usk02 2053 2 our -PRON- PRP$ cord-014516-r59usk02 2053 3 knowledge knowledge NN cord-014516-r59usk02 2053 4 , , , cord-014516-r59usk02 2053 5 the the DT cord-014516-r59usk02 2053 6 presense presense NN cord-014516-r59usk02 2053 7 of of IN cord-014516-r59usk02 2053 8 MMP-2 MMP-2 NNP cord-014516-r59usk02 2053 9 and and CC cord-014516-r59usk02 2053 10 -9 -9 NNP cord-014516-r59usk02 2053 11 has have VBZ cord-014516-r59usk02 2053 12 not not RB cord-014516-r59usk02 2053 13 been be VBN cord-014516-r59usk02 2053 14 studied study VBN cord-014516-r59usk02 2053 15 in in IN cord-014516-r59usk02 2053 16 the the DT cord-014516-r59usk02 2053 17 intestinal intestinal JJ cord-014516-r59usk02 2053 18 mucosal mucosal JJ cord-014516-r59usk02 2053 19 samples sample NNS cord-014516-r59usk02 2053 20 of of IN cord-014516-r59usk02 2053 21 healthy healthy JJ cord-014516-r59usk02 2053 22 dogs dog NNS cord-014516-r59usk02 2053 23 as as RB cord-014516-r59usk02 2053 24 well well RB cord-014516-r59usk02 2053 25 as as IN cord-014516-r59usk02 2053 26 in in IN cord-014516-r59usk02 2053 27 canine canine JJ cord-014516-r59usk02 2053 28 spontaneous spontaneous JJ cord-014516-r59usk02 2053 29 IBD IBD NNP cord-014516-r59usk02 2053 30 . . . cord-014516-r59usk02 2054 1 Thus thus RB cord-014516-r59usk02 2054 2 , , , cord-014516-r59usk02 2054 3 the the DT cord-014516-r59usk02 2054 4 main main JJ cord-014516-r59usk02 2054 5 aim aim NN cord-014516-r59usk02 2054 6 of of IN cord-014516-r59usk02 2054 7 this this DT cord-014516-r59usk02 2054 8 study study NN cord-014516-r59usk02 2054 9 was be VBD cord-014516-r59usk02 2054 10 to to TO cord-014516-r59usk02 2054 11 identify identify VB cord-014516-r59usk02 2054 12 the the DT cord-014516-r59usk02 2054 13 presence presence NN cord-014516-r59usk02 2054 14 of of IN cord-014516-r59usk02 2054 15 MMP-2 MMP-2 NNP cord-014516-r59usk02 2055 1 and and CC cord-014516-r59usk02 2055 2 -9 -9 ADD cord-014516-r59usk02 2055 3 in in IN cord-014516-r59usk02 2055 4 the the DT cord-014516-r59usk02 2055 5 mucosa mucosa NN cord-014516-r59usk02 2055 6 of of IN cord-014516-r59usk02 2055 7 the the DT cord-014516-r59usk02 2055 8 small small JJ cord-014516-r59usk02 2055 9 and and CC cord-014516-r59usk02 2055 10 large large JJ cord-014516-r59usk02 2055 11 intestines intestine NNS cord-014516-r59usk02 2055 12 of of IN cord-014516-r59usk02 2055 13 clinically clinically RB cord-014516-r59usk02 2055 14 healthy healthy JJ cord-014516-r59usk02 2055 15 beagle beagle NN cord-014516-r59usk02 2055 16 dogs dog NNS cord-014516-r59usk02 2055 17 using use VBG cord-014516-r59usk02 2055 18 gelatin gelatin NN cord-014516-r59usk02 2055 19 zymography zymography NNP cord-014516-r59usk02 2055 20 technique technique NN cord-014516-r59usk02 2055 21 . . . cord-014516-r59usk02 2056 1 For for IN cord-014516-r59usk02 2056 2 the the DT cord-014516-r59usk02 2056 3 study study NN cord-014516-r59usk02 2056 4 , , , cord-014516-r59usk02 2056 5 historical historical JJ cord-014516-r59usk02 2056 6 intestinal intestinal JJ cord-014516-r59usk02 2056 7 tissue tissue NN cord-014516-r59usk02 2056 8 samples sample NNS cord-014516-r59usk02 2056 9 from from IN cord-014516-r59usk02 2056 10 four four CD cord-014516-r59usk02 2056 11 different different JJ cord-014516-r59usk02 2056 12 parts part NNS cord-014516-r59usk02 2056 13 of of IN cord-014516-r59usk02 2056 14 the the DT cord-014516-r59usk02 2056 15 intestine intestine NN cord-014516-r59usk02 2056 16 ( ( -LRB- cord-014516-r59usk02 2056 17 duodenum duodenum NN cord-014516-r59usk02 2056 18 , , , cord-014516-r59usk02 2056 19 jejunum jejunum NNS cord-014516-r59usk02 2056 20 , , , cord-014516-r59usk02 2056 21 ileum ileum NN cord-014516-r59usk02 2056 22 and and CC cord-014516-r59usk02 2056 23 colon colon NN cord-014516-r59usk02 2056 24 ) ) -RRB- cord-014516-r59usk02 2056 25 were be VBD cord-014516-r59usk02 2056 26 used use VBN cord-014516-r59usk02 2056 27 . . . cord-014516-r59usk02 2057 1 The the DT cord-014516-r59usk02 2057 2 samples sample NNS cord-014516-r59usk02 2057 3 were be VBD cord-014516-r59usk02 2057 4 taken take VBN cord-014516-r59usk02 2057 5 and and CC cord-014516-r59usk02 2057 6 snap snap VB cord-014516-r59usk02 2057 7 frozen freeze VBN cord-014516-r59usk02 2057 8 in in IN cord-014516-r59usk02 2057 9 liquid liquid JJ cord-014516-r59usk02 2057 10 nitrogen nitrogen NN cord-014516-r59usk02 2057 11 during during IN cord-014516-r59usk02 2057 12 necropsy necropsy JJ cord-014516-r59usk02 2057 13 from from IN cord-014516-r59usk02 2057 14 12 12 CD cord-014516-r59usk02 2057 15 healthy healthy JJ cord-014516-r59usk02 2057 16 laboratory laboratory NN cord-014516-r59usk02 2057 17 beagle beagle NN cord-014516-r59usk02 2057 18 dogs dog NNS cord-014516-r59usk02 2057 19 after after IN cord-014516-r59usk02 2057 20 being be VBG cord-014516-r59usk02 2057 21 euthanized euthanize VBN cord-014516-r59usk02 2057 22 when when WRB cord-014516-r59usk02 2057 23 finishing finish VBG cord-014516-r59usk02 2057 24 unrelated unrelated JJ cord-014516-r59usk02 2057 25 long long JJ cord-014516-r59usk02 2057 26 - - HYPH cord-014516-r59usk02 2057 27 term term NN cord-014516-r59usk02 2057 28 trials trial NNS cord-014516-r59usk02 2057 29 studying study VBG cord-014516-r59usk02 2057 30 canine canine JJ cord-014516-r59usk02 2057 31 intestinal intestinal JJ cord-014516-r59usk02 2057 32 microbiota microbiota NN cord-014516-r59usk02 2057 33 . . . cord-014516-r59usk02 2058 1 Based base VBN cord-014516-r59usk02 2058 2 on on IN cord-014516-r59usk02 2058 3 WSAVA WSAVA NNP cord-014516-r59usk02 2058 4 histology histology NN cord-014516-r59usk02 2058 5 standards standard NNS cord-014516-r59usk02 2058 6 , , , cord-014516-r59usk02 2058 7 recorded record VBD cord-014516-r59usk02 2058 8 findings finding NNS cord-014516-r59usk02 2058 9 of of IN cord-014516-r59usk02 2058 10 all all DT cord-014516-r59usk02 2058 11 samples sample NNS cord-014516-r59usk02 2058 12 were be VBD cord-014516-r59usk02 2058 13 considered consider VBN cord-014516-r59usk02 2058 14 insignificant insignificant JJ cord-014516-r59usk02 2058 15 . . . cord-014516-r59usk02 2059 1 Pro Pro NNP cord-014516-r59usk02 2059 2 - - JJ cord-014516-r59usk02 2059 3 MMP-2 mmp-2 JJ cord-014516-r59usk02 2059 4 and and CC cord-014516-r59usk02 2059 5 -9 -9 NN cord-014516-r59usk02 2059 6 activities activity NNS cord-014516-r59usk02 2059 7 were be VBD cord-014516-r59usk02 2059 8 found find VBN cord-014516-r59usk02 2059 9 in in IN cord-014516-r59usk02 2059 10 17/48 17/48 CD cord-014516-r59usk02 2059 11 ( ( -LRB- cord-014516-r59usk02 2059 12 35 35 CD cord-014516-r59usk02 2059 13 % % NN cord-014516-r59usk02 2059 14 ) ) -RRB- cord-014516-r59usk02 2059 15 and and CC cord-014516-r59usk02 2059 16 25/48 25/48 CD cord-014516-r59usk02 2059 17 ( ( -LRB- cord-014516-r59usk02 2059 18 52 52 CD cord-014516-r59usk02 2059 19 % % NN cord-014516-r59usk02 2059 20 ) ) -RRB- cord-014516-r59usk02 2059 21 of of IN cord-014516-r59usk02 2059 22 the the DT cord-014516-r59usk02 2059 23 samples sample NNS cord-014516-r59usk02 2059 24 , , , cord-014516-r59usk02 2059 25 respectively respectively RB cord-014516-r59usk02 2059 26 . . . cord-014516-r59usk02 2060 1 Among among IN cord-014516-r59usk02 2060 2 four four CD cord-014516-r59usk02 2060 3 different different JJ cord-014516-r59usk02 2060 4 parts part NNS cord-014516-r59usk02 2060 5 of of IN cord-014516-r59usk02 2060 6 the the DT cord-014516-r59usk02 2060 7 intestine intestine NN cord-014516-r59usk02 2060 8 of of IN cord-014516-r59usk02 2060 9 12 12 CD cord-014516-r59usk02 2060 10 dogs dog NNS cord-014516-r59usk02 2060 11 , , , cord-014516-r59usk02 2060 12 the the DT cord-014516-r59usk02 2060 13 ileum ileum NN cord-014516-r59usk02 2060 14 had have VBD cord-014516-r59usk02 2060 15 the the DT cord-014516-r59usk02 2060 16 highest high JJS cord-014516-r59usk02 2060 17 positivity positivity NN cord-014516-r59usk02 2060 18 rates rate NNS cord-014516-r59usk02 2060 19 of of IN cord-014516-r59usk02 2060 20 7/12 7/12 CD cord-014516-r59usk02 2060 21 ( ( -LRB- cord-014516-r59usk02 2060 22 58.3 58.3 CD cord-014516-r59usk02 2060 23 % % NN cord-014516-r59usk02 2060 24 ) ) -RRB- cord-014516-r59usk02 2060 25 and and CC cord-014516-r59usk02 2060 26 8/12 8/12 CD cord-014516-r59usk02 2060 27 ( ( -LRB- cord-014516-r59usk02 2060 28 66.7 66.7 CD cord-014516-r59usk02 2060 29 % % NN cord-014516-r59usk02 2060 30 ) ) -RRB- cord-014516-r59usk02 2060 31 for for IN cord-014516-r59usk02 2060 32 pro pro JJ cord-014516-r59usk02 2060 33 - - JJ cord-014516-r59usk02 2060 34 MMP-2 mmp-2 JJ cord-014516-r59usk02 2060 35 and and CC cord-014516-r59usk02 2060 36 -9 -9 NN cord-014516-r59usk02 2060 37 activities activity NNS cord-014516-r59usk02 2060 38 , , , cord-014516-r59usk02 2060 39 respectively respectively RB cord-014516-r59usk02 2060 40 . . . cord-014516-r59usk02 2061 1 However however RB cord-014516-r59usk02 2061 2 , , , cord-014516-r59usk02 2061 3 statistical statistical JJ cord-014516-r59usk02 2061 4 analysis analysis NN cord-014516-r59usk02 2061 5 showed show VBD cord-014516-r59usk02 2061 6 no no DT cord-014516-r59usk02 2061 7 significant significant JJ cord-014516-r59usk02 2061 8 difference difference NN cord-014516-r59usk02 2061 9 of of IN cord-014516-r59usk02 2061 10 pro pro JJ cord-014516-r59usk02 2061 11 - - JJ cord-014516-r59usk02 2061 12 MMP-2 mmp-2 JJ cord-014516-r59usk02 2061 13 and and CC cord-014516-r59usk02 2061 14 -9 -9 NN cord-014516-r59usk02 2061 15 activities activity NNS cord-014516-r59usk02 2061 16 between between IN cord-014516-r59usk02 2061 17 the the DT cord-014516-r59usk02 2061 18 separate separate JJ cord-014516-r59usk02 2061 19 parts part NNS cord-014516-r59usk02 2061 20 of of IN cord-014516-r59usk02 2061 21 the the DT cord-014516-r59usk02 2061 22 intestine intestine NN cord-014516-r59usk02 2061 23 ( ( -LRB- cord-014516-r59usk02 2061 24 P p NN cord-014516-r59usk02 2061 25 > > XX cord-014516-r59usk02 2061 26 0.05 0.05 CD cord-014516-r59usk02 2061 27 ) ) -RRB- cord-014516-r59usk02 2061 28 . . . cord-014516-r59usk02 2062 1 The the DT cord-014516-r59usk02 2062 2 enzyme enzyme NN cord-014516-r59usk02 2062 3 activities activity NNS cord-014516-r59usk02 2062 4 ranged range VBD cord-014516-r59usk02 2062 5 for for IN cord-014516-r59usk02 2062 6 pro pro JJ cord-014516-r59usk02 2062 7 - - JJ cord-014516-r59usk02 2062 8 MMP-2 MMP-2 NNP cord-014516-r59usk02 2062 9 between between IN cord-014516-r59usk02 2062 10 0.015 0.015 CD cord-014516-r59usk02 2062 11 and and CC cord-014516-r59usk02 2062 12 6.449 6.449 CD cord-014516-r59usk02 2062 13 arbitrary arbitrary JJ cord-014516-r59usk02 2062 14 units unit NNS cord-014516-r59usk02 2062 15 ( ( -LRB- cord-014516-r59usk02 2062 16 AU AU NNP cord-014516-r59usk02 2062 17 ) ) -RRB- cord-014516-r59usk02 2062 18 and and CC cord-014516-r59usk02 2062 19 for for IN cord-014516-r59usk02 2062 20 pro pro JJ cord-014516-r59usk02 2062 21 - - JJ cord-014516-r59usk02 2062 22 MMP-9 mmp-9 JJ cord-014516-r59usk02 2062 23 between between IN cord-014516-r59usk02 2062 24 0.018 0.018 CD cord-014516-r59usk02 2062 25 and and CC cord-014516-r59usk02 2062 26 5.680 5.680 CD cord-014516-r59usk02 2062 27 AU AU NNP cord-014516-r59usk02 2062 28 . . . cord-014516-r59usk02 2063 1 None none NN cord-014516-r59usk02 2063 2 of of IN cord-014516-r59usk02 2063 3 the the DT cord-014516-r59usk02 2063 4 intestinal intestinal JJ cord-014516-r59usk02 2063 5 samples sample NNS cord-014516-r59usk02 2063 6 showed show VBD cord-014516-r59usk02 2063 7 gelatinolytic gelatinolytic JJ cord-014516-r59usk02 2063 8 activity activity NN cord-014516-r59usk02 2063 9 corresponding correspond VBG cord-014516-r59usk02 2063 10 to to IN cord-014516-r59usk02 2063 11 the the DT cord-014516-r59usk02 2063 12 control control NN cord-014516-r59usk02 2063 13 bands band NNS cord-014516-r59usk02 2063 14 of of IN cord-014516-r59usk02 2063 15 active active JJ cord-014516-r59usk02 2063 16 MMP-2 MMP-2 NNP cord-014516-r59usk02 2063 17 and and CC cord-014516-r59usk02 2063 18 MMP-9 MMP-9 NNP cord-014516-r59usk02 2063 19 . . . cord-014516-r59usk02 2064 1 This this DT cord-014516-r59usk02 2064 2 study study NN cord-014516-r59usk02 2064 3 showed show VBD cord-014516-r59usk02 2064 4 that that IN cord-014516-r59usk02 2064 5 pro pro JJ cord-014516-r59usk02 2064 6 - - JJ cord-014516-r59usk02 2064 7 MMP-2 mmp-2 JJ cord-014516-r59usk02 2064 8 and and CC cord-014516-r59usk02 2064 9 -9 -9 NNP cord-014516-r59usk02 2064 10 could could MD cord-014516-r59usk02 2064 11 be be VB cord-014516-r59usk02 2064 12 detected detect VBN cord-014516-r59usk02 2064 13 in in IN cord-014516-r59usk02 2064 14 the the DT cord-014516-r59usk02 2064 15 intestinal intestinal JJ cord-014516-r59usk02 2064 16 mucosa mucosa NN cord-014516-r59usk02 2064 17 of of IN cord-014516-r59usk02 2064 18 healthy healthy JJ cord-014516-r59usk02 2064 19 dogs dog NNS cord-014516-r59usk02 2064 20 using use VBG cord-014516-r59usk02 2064 21 zymography zymography NNP cord-014516-r59usk02 2064 22 , , , cord-014516-r59usk02 2064 23 which which WDT cord-014516-r59usk02 2064 24 seems seem VBZ cord-014516-r59usk02 2064 25 to to TO cord-014516-r59usk02 2064 26 be be VB cord-014516-r59usk02 2064 27 a a DT cord-014516-r59usk02 2064 28 useful useful JJ cord-014516-r59usk02 2064 29 tool tool NN cord-014516-r59usk02 2064 30 to to TO cord-014516-r59usk02 2064 31 evaluate evaluate VB cord-014516-r59usk02 2064 32 the the DT cord-014516-r59usk02 2064 33 role role NN cord-014516-r59usk02 2064 34 of of IN cord-014516-r59usk02 2064 35 MMP-2 MMP-2 NNP cord-014516-r59usk02 2064 36 and and CC cord-014516-r59usk02 2065 1 -9 -9 NNP cord-014516-r59usk02 2065 2 in in IN cord-014516-r59usk02 2065 3 the the DT cord-014516-r59usk02 2065 4 pathogenesis pathogenesis NN cord-014516-r59usk02 2065 5 of of IN cord-014516-r59usk02 2065 6 canine canine JJ cord-014516-r59usk02 2065 7 chronic chronic JJ cord-014516-r59usk02 2065 8 enteropathies enteropathy NNS cord-014516-r59usk02 2065 9 , , , cord-014516-r59usk02 2065 10 including include VBG cord-014516-r59usk02 2065 11 inflammatory inflammatory JJ cord-014516-r59usk02 2065 12 bowel bowel NN cord-014516-r59usk02 2065 13 diseases disease NNS cord-014516-r59usk02 2065 14 . . . cord-014516-r59usk02 2066 1 No no DT cord-014516-r59usk02 2066 2 conflicts conflict NNS cord-014516-r59usk02 2066 3 of of IN cord-014516-r59usk02 2066 4 interest interest NN cord-014516-r59usk02 2066 5 reported report VBN cord-014516-r59usk02 2066 6 . . . cord-014516-r59usk02 2067 1 Digestive digestive JJ cord-014516-r59usk02 2067 2 perforation perforation NN cord-014516-r59usk02 2067 3 is be VBZ cord-014516-r59usk02 2067 4 called call VBN cord-014516-r59usk02 2067 5 spontaneous spontaneous JJ cord-014516-r59usk02 2067 6 when when WRB cord-014516-r59usk02 2067 7 it -PRON- PRP cord-014516-r59usk02 2067 8 arises arise VBZ cord-014516-r59usk02 2067 9 in in IN cord-014516-r59usk02 2067 10 the the DT cord-014516-r59usk02 2067 11 absence absence NN cord-014516-r59usk02 2067 12 of of IN cord-014516-r59usk02 2067 13 foreign foreign JJ cord-014516-r59usk02 2067 14 body body NN cord-014516-r59usk02 2067 15 ingestion ingestion NN cord-014516-r59usk02 2067 16 , , , cord-014516-r59usk02 2067 17 gastric gastric JJ cord-014516-r59usk02 2067 18 dilatation dilatation NN cord-014516-r59usk02 2067 19 and and CC cord-014516-r59usk02 2067 20 volvulus volvulus NN cord-014516-r59usk02 2067 21 , , , cord-014516-r59usk02 2067 22 external external JJ cord-014516-r59usk02 2067 23 trauma trauma NN cord-014516-r59usk02 2067 24 , , , cord-014516-r59usk02 2067 25 or or CC cord-014516-r59usk02 2067 26 previous previous JJ cord-014516-r59usk02 2067 27 digestive digestive JJ cord-014516-r59usk02 2067 28 surgery surgery NN cord-014516-r59usk02 2067 29 . . . cord-014516-r59usk02 2068 1 In in IN cord-014516-r59usk02 2068 2 dogs dog NNS cord-014516-r59usk02 2068 3 many many JJ cord-014516-r59usk02 2068 4 predisposing predisposing JJ cord-014516-r59usk02 2068 5 factors factor NNS cord-014516-r59usk02 2068 6 have have VBP cord-014516-r59usk02 2068 7 been be VBN cord-014516-r59usk02 2068 8 identified identify VBN cord-014516-r59usk02 2068 9 , , , cord-014516-r59usk02 2068 10 including include VBG cord-014516-r59usk02 2068 11 antiinflammatory antiinflammatory JJ cord-014516-r59usk02 2068 12 administration administration NN cord-014516-r59usk02 2068 13 , , , cord-014516-r59usk02 2068 14 severe severe JJ cord-014516-r59usk02 2068 15 hepatic hepatic JJ cord-014516-r59usk02 2068 16 or or CC cord-014516-r59usk02 2068 17 renal renal JJ cord-014516-r59usk02 2068 18 disease disease NN cord-014516-r59usk02 2068 19 , , , cord-014516-r59usk02 2068 20 stress stress NN cord-014516-r59usk02 2068 21 , , , cord-014516-r59usk02 2068 22 shock shock NN cord-014516-r59usk02 2068 23 , , , cord-014516-r59usk02 2068 24 gastric gastric JJ cord-014516-r59usk02 2068 25 hyperacidity hyperacidity NN cord-014516-r59usk02 2068 26 , , , cord-014516-r59usk02 2068 27 neoplasia neoplasia NN cord-014516-r59usk02 2068 28 and and CC cord-014516-r59usk02 2068 29 idiopathic idiopathic JJ cord-014516-r59usk02 2068 30 inflammatory inflammatory JJ cord-014516-r59usk02 2068 31 bowel bowel NN cord-014516-r59usk02 2068 32 disease disease NN cord-014516-r59usk02 2068 33 . . . cord-014516-r59usk02 2069 1 Spontaneous spontaneous JJ cord-014516-r59usk02 2069 2 digestive digestive JJ cord-014516-r59usk02 2069 3 perforation perforation NN cord-014516-r59usk02 2069 4 has have VBZ cord-014516-r59usk02 2069 5 been be VBN cord-014516-r59usk02 2069 6 uncommonly uncommonly RB cord-014516-r59usk02 2069 7 reported report VBN cord-014516-r59usk02 2069 8 in in IN cord-014516-r59usk02 2069 9 cats cat NNS cord-014516-r59usk02 2069 10 . . . cord-014516-r59usk02 2070 1 The the DT cord-014516-r59usk02 2070 2 objectives objective NNS cord-014516-r59usk02 2070 3 of of IN cord-014516-r59usk02 2070 4 this this DT cord-014516-r59usk02 2070 5 study study NN cord-014516-r59usk02 2070 6 were be VBD cord-014516-r59usk02 2070 7 to to TO cord-014516-r59usk02 2070 8 describe describe VB cord-014516-r59usk02 2070 9 the the DT cord-014516-r59usk02 2070 10 clinical clinical JJ cord-014516-r59usk02 2070 11 characteristics characteristic NNS cord-014516-r59usk02 2070 12 of of IN cord-014516-r59usk02 2070 13 spontaneous spontaneous JJ cord-014516-r59usk02 2070 14 digestive digestive JJ cord-014516-r59usk02 2070 15 perforation perforation NN cord-014516-r59usk02 2070 16 in in IN cord-014516-r59usk02 2070 17 cats cat NNS cord-014516-r59usk02 2070 18 , , , cord-014516-r59usk02 2070 19 and and CC cord-014516-r59usk02 2070 20 to to TO cord-014516-r59usk02 2070 21 compare compare VB cord-014516-r59usk02 2070 22 the the DT cord-014516-r59usk02 2070 23 frequency frequency NN cord-014516-r59usk02 2070 24 of of IN cord-014516-r59usk02 2070 25 malignant malignant JJ cord-014516-r59usk02 2070 26 versus versus IN cord-014516-r59usk02 2070 27 non non JJ cord-014516-r59usk02 2070 28 - - JJ cord-014516-r59usk02 2070 29 malignant malignant JJ cord-014516-r59usk02 2070 30 causes cause NNS cord-014516-r59usk02 2070 31 for for IN cord-014516-r59usk02 2070 32 these these DT cord-014516-r59usk02 2070 33 perforations perforation NNS cord-014516-r59usk02 2070 34 . . . cord-014516-r59usk02 2071 1 To to TO cord-014516-r59usk02 2071 2 be be VB cord-014516-r59usk02 2071 3 included include VBN cord-014516-r59usk02 2071 4 in in IN cord-014516-r59usk02 2071 5 this this DT cord-014516-r59usk02 2071 6 study study NN cord-014516-r59usk02 2071 7 , , , cord-014516-r59usk02 2071 8 the the DT cord-014516-r59usk02 2071 9 perforation perforation NN cord-014516-r59usk02 2071 10 had have VBD cord-014516-r59usk02 2071 11 to to TO cord-014516-r59usk02 2071 12 be be VB cord-014516-r59usk02 2071 13 spontaneous spontaneous JJ cord-014516-r59usk02 2071 14 and and CC cord-014516-r59usk02 2071 15 confirmed confirm VBN cord-014516-r59usk02 2071 16 by by IN cord-014516-r59usk02 2071 17 exploratory exploratory JJ cord-014516-r59usk02 2071 18 surgery surgery NN cord-014516-r59usk02 2071 19 . . . cord-014516-r59usk02 2072 1 The the DT cord-014516-r59usk02 2072 2 medical medical JJ cord-014516-r59usk02 2072 3 records record NNS cord-014516-r59usk02 2072 4 of of IN cord-014516-r59usk02 2072 5 13 13 CD cord-014516-r59usk02 2072 6 cats cat NNS cord-014516-r59usk02 2072 7 diagnosed diagnose VBN cord-014516-r59usk02 2072 8 as as IN cord-014516-r59usk02 2072 9 having have VBG cord-014516-r59usk02 2072 10 spontaneous spontaneous JJ cord-014516-r59usk02 2072 11 digestive digestive JJ cord-014516-r59usk02 2072 12 perforation perforation NN cord-014516-r59usk02 2072 13 between between IN cord-014516-r59usk02 2072 14 2010 2010 CD cord-014516-r59usk02 2072 15 and and CC cord-014516-r59usk02 2072 16 2013 2013 CD cord-014516-r59usk02 2072 17 were be VBD cord-014516-r59usk02 2072 18 reviewed review VBN cord-014516-r59usk02 2072 19 . . . cord-014516-r59usk02 2073 1 The the DT cord-014516-r59usk02 2073 2 mean mean JJ cord-014516-r59usk02 2073 3 age age NN cord-014516-r59usk02 2073 4 of of IN cord-014516-r59usk02 2073 5 cats cat NNS cord-014516-r59usk02 2073 6 was be VBD cord-014516-r59usk02 2073 7 7.6 7.6 CD cord-014516-r59usk02 2073 8 years year NNS cord-014516-r59usk02 2073 9 ( ( -LRB- cord-014516-r59usk02 2073 10 9 9 CD cord-014516-r59usk02 2073 11 months month NNS cord-014516-r59usk02 2073 12 to to IN cord-014516-r59usk02 2073 13 17 17 CD cord-014516-r59usk02 2073 14 years year NNS cord-014516-r59usk02 2073 15 ) ) -RRB- cord-014516-r59usk02 2073 16 . . . cord-014516-r59usk02 2074 1 Five five CD cord-014516-r59usk02 2074 2 cats cat NNS cord-014516-r59usk02 2074 3 had have VBD cord-014516-r59usk02 2074 4 concurrent concurrent JJ cord-014516-r59usk02 2074 5 illnesses illness NNS cord-014516-r59usk02 2074 6 including include VBG cord-014516-r59usk02 2074 7 viral viral JJ cord-014516-r59usk02 2074 8 upper upper JJ cord-014516-r59usk02 2074 9 respiratory respiratory JJ cord-014516-r59usk02 2074 10 tract tract NN cord-014516-r59usk02 2074 11 disease disease NN cord-014516-r59usk02 2074 12 , , , cord-014516-r59usk02 2074 13 pancreatitis pancreatitis NN cord-014516-r59usk02 2074 14 and and CC cord-014516-r59usk02 2074 15 chronic chronic JJ cord-014516-r59usk02 2074 16 kidney kidney NN cord-014516-r59usk02 2074 17 disease disease NN cord-014516-r59usk02 2074 18 . . . cord-014516-r59usk02 2075 1 The the DT cord-014516-r59usk02 2075 2 most most RBS cord-014516-r59usk02 2075 3 frequently frequently RB cord-014516-r59usk02 2075 4 reported report VBN cord-014516-r59usk02 2075 5 signs sign NNS cord-014516-r59usk02 2075 6 included include VBD cord-014516-r59usk02 2075 7 anorexia anorexia NN cord-014516-r59usk02 2075 8 ( ( -LRB- cord-014516-r59usk02 2075 9 85 85 CD cord-014516-r59usk02 2075 10 % % NN cord-014516-r59usk02 2075 11 ) ) -RRB- cord-014516-r59usk02 2075 12 , , , cord-014516-r59usk02 2075 13 vomiting vomit VBG cord-014516-r59usk02 2075 14 ( ( -LRB- cord-014516-r59usk02 2075 15 61 61 CD cord-014516-r59usk02 2075 16 % % NN cord-014516-r59usk02 2075 17 ) ) -RRB- cord-014516-r59usk02 2075 18 , , , cord-014516-r59usk02 2075 19 and and CC cord-014516-r59usk02 2075 20 lethargy lethargy NN cord-014516-r59usk02 2075 21 ( ( -LRB- cord-014516-r59usk02 2075 22 54 54 CD cord-014516-r59usk02 2075 23 % % NN cord-014516-r59usk02 2075 24 ) ) -RRB- cord-014516-r59usk02 2075 25 . . . cord-014516-r59usk02 2076 1 Histological histological JJ cord-014516-r59usk02 2076 2 examination examination NN cord-014516-r59usk02 2076 3 was be VBD cord-014516-r59usk02 2076 4 performed perform VBN cord-014516-r59usk02 2076 5 in in IN cord-014516-r59usk02 2076 6 11 11 CD cord-014516-r59usk02 2076 7 cats cat NNS cord-014516-r59usk02 2076 8 and and CC cord-014516-r59usk02 2076 9 diagnosed diagnose VBN cord-014516-r59usk02 2076 10 alimentary alimentary JJ cord-014516-r59usk02 2076 11 lymphoma lymphoma NN cord-014516-r59usk02 2076 12 in in IN cord-014516-r59usk02 2076 13 54 54 CD cord-014516-r59usk02 2076 14 % % NN cord-014516-r59usk02 2076 15 and and CC cord-014516-r59usk02 2076 16 inflammatory inflammatory JJ cord-014516-r59usk02 2076 17 lesions lesion NNS cord-014516-r59usk02 2076 18 in in IN cord-014516-r59usk02 2076 19 the the DT cord-014516-r59usk02 2076 20 other other JJ cord-014516-r59usk02 2076 21 46 46 CD cord-014516-r59usk02 2076 22 % % NN cord-014516-r59usk02 2076 23 of of IN cord-014516-r59usk02 2076 24 them -PRON- PRP cord-014516-r59usk02 2076 25 . . . cord-014516-r59usk02 2077 1 Six six CD cord-014516-r59usk02 2077 2 cats cat NNS cord-014516-r59usk02 2077 3 had have VBD cord-014516-r59usk02 2077 4 received receive VBN cord-014516-r59usk02 2077 5 anti anti JJ cord-014516-r59usk02 2077 6 - - JJ cord-014516-r59usk02 2077 7 inflammatory inflammatory JJ cord-014516-r59usk02 2077 8 within within IN cord-014516-r59usk02 2077 9 the the DT cord-014516-r59usk02 2077 10 previous previous JJ cord-014516-r59usk02 2077 11 3 3 CD cord-014516-r59usk02 2077 12 months month NNS cord-014516-r59usk02 2077 13 . . . cord-014516-r59usk02 2078 1 Half half NN cord-014516-r59usk02 2078 2 of of IN cord-014516-r59usk02 2078 3 them -PRON- PRP cord-014516-r59usk02 2078 4 were be VBD cord-014516-r59usk02 2078 5 finally finally RB cord-014516-r59usk02 2078 6 diagnosed diagnose VBN cord-014516-r59usk02 2078 7 with with IN cord-014516-r59usk02 2078 8 lymphoma lymphoma NN cord-014516-r59usk02 2078 9 . . . cord-014516-r59usk02 2079 1 Five five CD cord-014516-r59usk02 2079 2 cats cat NNS cord-014516-r59usk02 2079 3 with with IN cord-014516-r59usk02 2079 4 lymphoma lymphoma NN cord-014516-r59usk02 2079 5 received receive VBD cord-014516-r59usk02 2079 6 chemotherapy chemotherapy NN cord-014516-r59usk02 2079 7 . . . cord-014516-r59usk02 2080 1 Three three CD cord-014516-r59usk02 2080 2 cats cat NNS cord-014516-r59usk02 2080 3 died die VBD cord-014516-r59usk02 2080 4 early early RB cord-014516-r59usk02 2080 5 in in IN cord-014516-r59usk02 2080 6 the the DT cord-014516-r59usk02 2080 7 postoperative postoperative JJ cord-014516-r59usk02 2080 8 recovery recovery NN cord-014516-r59usk02 2080 9 period period NN cord-014516-r59usk02 2080 10 , , , cord-014516-r59usk02 2080 11 5 5 CD cord-014516-r59usk02 2080 12 cats cat NNS cord-014516-r59usk02 2080 13 were be VBD cord-014516-r59usk02 2080 14 euthanized euthanize VBN cord-014516-r59usk02 2080 15 12 12 CD cord-014516-r59usk02 2080 16 to to TO cord-014516-r59usk02 2080 17 146 146 CD cord-014516-r59usk02 2080 18 days day NNS cord-014516-r59usk02 2080 19 after after IN cord-014516-r59usk02 2080 20 surgery surgery NN cord-014516-r59usk02 2080 21 , , , cord-014516-r59usk02 2080 22 and and CC cord-014516-r59usk02 2080 23 2 2 CD cord-014516-r59usk02 2080 24 cats cat NNS cord-014516-r59usk02 2080 25 were be VBD cord-014516-r59usk02 2080 26 still still RB cord-014516-r59usk02 2080 27 alive alive JJ cord-014516-r59usk02 2080 28 at at IN cord-014516-r59usk02 2080 29 the the DT cord-014516-r59usk02 2080 30 end end NN cord-014516-r59usk02 2080 31 of of IN cord-014516-r59usk02 2080 32 this this DT cord-014516-r59usk02 2080 33 study study NN cord-014516-r59usk02 2080 34 . . . cord-014516-r59usk02 2081 1 In in IN cord-014516-r59usk02 2081 2 the the DT cord-014516-r59usk02 2081 3 absence absence NN cord-014516-r59usk02 2081 4 of of IN cord-014516-r59usk02 2081 5 pneumoperitoneum pneumoperitoneum NN cord-014516-r59usk02 2081 6 , , , cord-014516-r59usk02 2081 7 clinical clinical JJ cord-014516-r59usk02 2081 8 signs sign NNS cord-014516-r59usk02 2081 9 and and CC cord-014516-r59usk02 2081 10 clinicopathological clinicopathological NN cord-014516-r59usk02 2081 11 abnormalities abnormality NNS cord-014516-r59usk02 2081 12 are be VBP cord-014516-r59usk02 2081 13 not not RB cord-014516-r59usk02 2081 14 specific specific JJ cord-014516-r59usk02 2081 15 enough enough RB cord-014516-r59usk02 2081 16 to to TO cord-014516-r59usk02 2081 17 allow allow VB cord-014516-r59usk02 2081 18 differentiation differentiation NN cord-014516-r59usk02 2081 19 between between IN cord-014516-r59usk02 2081 20 cats cat NNS cord-014516-r59usk02 2081 21 with with IN cord-014516-r59usk02 2081 22 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2081 23 ulceration ulceration NN cord-014516-r59usk02 2081 24 and and CC cord-014516-r59usk02 2081 25 those those DT cord-014516-r59usk02 2081 26 with with IN cord-014516-r59usk02 2081 27 perforation perforation NN cord-014516-r59usk02 2081 28 . . . cord-014516-r59usk02 2082 1 In in IN cord-014516-r59usk02 2082 2 most most JJS cord-014516-r59usk02 2082 3 cases case NNS cord-014516-r59usk02 2082 4 , , , cord-014516-r59usk02 2082 5 there there EX cord-014516-r59usk02 2082 6 is be VBZ cord-014516-r59usk02 2082 7 no no DT cord-014516-r59usk02 2082 8 diagnostic diagnostic JJ cord-014516-r59usk02 2082 9 test test NN cord-014516-r59usk02 2082 10 that that WDT cord-014516-r59usk02 2082 11 individually individually RB cord-014516-r59usk02 2082 12 determine determine VBP cord-014516-r59usk02 2082 13 whether whether IN cord-014516-r59usk02 2082 14 perforation perforation NN cord-014516-r59usk02 2082 15 has have VBZ cord-014516-r59usk02 2082 16 occurred occur VBN cord-014516-r59usk02 2082 17 or or CC cord-014516-r59usk02 2082 18 is be VBZ cord-014516-r59usk02 2082 19 impending impending JJ cord-014516-r59usk02 2082 20 , , , cord-014516-r59usk02 2082 21 and and CC cord-014516-r59usk02 2082 22 clinicians clinician NNS cord-014516-r59usk02 2082 23 should should MD cord-014516-r59usk02 2082 24 use use VB cord-014516-r59usk02 2082 25 of of IN cord-014516-r59usk02 2082 26 multimodality multimodality NN cord-014516-r59usk02 2082 27 diagnostic diagnostic JJ cord-014516-r59usk02 2082 28 procedures procedure NNS cord-014516-r59usk02 2082 29 such such JJ cord-014516-r59usk02 2082 30 as as IN cord-014516-r59usk02 2082 31 radiography radiography NN cord-014516-r59usk02 2082 32 , , , cord-014516-r59usk02 2082 33 ultrasonography ultrasonography NN cord-014516-r59usk02 2082 34 , , , cord-014516-r59usk02 2082 35 endoscopy endoscopy NN cord-014516-r59usk02 2082 36 , , , cord-014516-r59usk02 2082 37 and and CC cord-014516-r59usk02 2082 38 abdominal abdominal JJ cord-014516-r59usk02 2082 39 fluid fluid JJ cord-014516-r59usk02 2082 40 cytopathology cytopathology NN cord-014516-r59usk02 2082 41 to to TO cord-014516-r59usk02 2082 42 avoid avoid VB cord-014516-r59usk02 2082 43 delay delay NN cord-014516-r59usk02 2082 44 in in IN cord-014516-r59usk02 2082 45 diagnosis diagnosis NN cord-014516-r59usk02 2082 46 of of IN cord-014516-r59usk02 2082 47 digestive digestive JJ cord-014516-r59usk02 2082 48 perforation perforation NN cord-014516-r59usk02 2082 49 . . . cord-014516-r59usk02 2083 1 Histological histological JJ cord-014516-r59usk02 2083 2 examination examination NN cord-014516-r59usk02 2083 3 of of IN cord-014516-r59usk02 2083 4 ulceration ulceration NN cord-014516-r59usk02 2083 5 is be VBZ cord-014516-r59usk02 2083 6 essential essential JJ cord-014516-r59usk02 2083 7 as as IN cord-014516-r59usk02 2083 8 lymphoma lymphoma NN cord-014516-r59usk02 2083 9 should should MD cord-014516-r59usk02 2083 10 be be VB cord-014516-r59usk02 2083 11 suspected suspect VBN cord-014516-r59usk02 2083 12 in in IN cord-014516-r59usk02 2083 13 all all DT cord-014516-r59usk02 2083 14 cats cat NNS cord-014516-r59usk02 2083 15 presented present VBN cord-014516-r59usk02 2083 16 with with IN cord-014516-r59usk02 2083 17 spontaneous spontaneous JJ cord-014516-r59usk02 2083 18 perforation perforation NN cord-014516-r59usk02 2083 19 . . . cord-014516-r59usk02 2084 1 The the DT cord-014516-r59usk02 2084 2 link link NN cord-014516-r59usk02 2084 3 between between IN cord-014516-r59usk02 2084 4 anti anti JJ cord-014516-r59usk02 2084 5 - - JJ cord-014516-r59usk02 2084 6 inflammatory inflammatory JJ cord-014516-r59usk02 2084 7 administration administration NN cord-014516-r59usk02 2084 8 and and CC cord-014516-r59usk02 2084 9 spontaneous spontaneous JJ cord-014516-r59usk02 2084 10 perforation perforation NN cord-014516-r59usk02 2084 11 in in IN cord-014516-r59usk02 2084 12 cats cat NNS cord-014516-r59usk02 2084 13 is be VBZ cord-014516-r59usk02 2084 14 not not RB cord-014516-r59usk02 2084 15 established establish VBN cord-014516-r59usk02 2084 16 . . . cord-014516-r59usk02 2085 1 No no DT cord-014516-r59usk02 2085 2 conflicts conflict NNS cord-014516-r59usk02 2085 3 of of IN cord-014516-r59usk02 2085 4 interest interest NN cord-014516-r59usk02 2085 5 reported report VBN cord-014516-r59usk02 2085 6 . . . cord-014516-r59usk02 2086 1 Campylobacter Campylobacter NNP cord-014516-r59usk02 2086 2 species specie NNS cord-014516-r59usk02 2086 3 are be VBP cord-014516-r59usk02 2086 4 commonly commonly RB cord-014516-r59usk02 2086 5 isolated isolate VBN cord-014516-r59usk02 2086 6 from from IN cord-014516-r59usk02 2086 7 faeces faece NNS cord-014516-r59usk02 2086 8 of of IN cord-014516-r59usk02 2086 9 dogs dog NNS cord-014516-r59usk02 2086 10 and and CC cord-014516-r59usk02 2086 11 cats cat NNS cord-014516-r59usk02 2086 12 with with IN cord-014516-r59usk02 2086 13 C. C. NNP cord-014516-r59usk02 2086 14 upsaliensis upsaliensis NNP cord-014516-r59usk02 2086 15 ( ( -LRB- cord-014516-r59usk02 2086 16 CU CU NNP cord-014516-r59usk02 2086 17 ) ) -RRB- cord-014516-r59usk02 2086 18 and and CC cord-014516-r59usk02 2086 19 C. C. NNP cord-014516-r59usk02 2086 20 helveticus helveticus NNP cord-014516-r59usk02 2086 21 ( ( -LRB- cord-014516-r59usk02 2086 22 CH CH NNP cord-014516-r59usk02 2086 23 ) ) -RRB- cord-014516-r59usk02 2086 24 being be VBG cord-014516-r59usk02 2086 25 the the DT cord-014516-r59usk02 2086 26 most most RBS cord-014516-r59usk02 2086 27 frequently frequently RB cord-014516-r59usk02 2086 28 isolated isolate VBN cord-014516-r59usk02 2086 29 . . . cord-014516-r59usk02 2087 1 These these DT cord-014516-r59usk02 2087 2 two two CD cord-014516-r59usk02 2087 3 species specie NNS cord-014516-r59usk02 2087 4 are be VBP cord-014516-r59usk02 2087 5 usually usually RB cord-014516-r59usk02 2087 6 not not RB cord-014516-r59usk02 2087 7 considered consider VBN cord-014516-r59usk02 2087 8 pathogenic pathogenic JJ cord-014516-r59usk02 2087 9 in in IN cord-014516-r59usk02 2087 10 dogs dog NNS cord-014516-r59usk02 2087 11 and and CC cord-014516-r59usk02 2087 12 cats cat NNS cord-014516-r59usk02 2087 13 and and CC cord-014516-r59usk02 2087 14 are be VBP cord-014516-r59usk02 2087 15 closely closely RB cord-014516-r59usk02 2087 16 related related JJ cord-014516-r59usk02 2087 17 to to IN cord-014516-r59usk02 2087 18 each each DT cord-014516-r59usk02 2087 19 other other JJ cord-014516-r59usk02 2087 20 and and CC cord-014516-r59usk02 2087 21 to to IN cord-014516-r59usk02 2087 22 C. C. NNP cord-014516-r59usk02 2087 23 jejuni jejuni NNP cord-014516-r59usk02 2087 24 , , , cord-014516-r59usk02 2087 25 the the DT cord-014516-r59usk02 2087 26 most most RBS cord-014516-r59usk02 2087 27 common common JJ cord-014516-r59usk02 2087 28 cause cause NN cord-014516-r59usk02 2087 29 of of IN cord-014516-r59usk02 2087 30 bacterial bacterial JJ cord-014516-r59usk02 2087 31 gastroenteritis gastroenteritis NN cord-014516-r59usk02 2087 32 in in IN cord-014516-r59usk02 2087 33 humans human NNS cord-014516-r59usk02 2087 34 in in IN cord-014516-r59usk02 2087 35 the the DT cord-014516-r59usk02 2087 36 developed develop VBN cord-014516-r59usk02 2087 37 world world NN cord-014516-r59usk02 2087 38 . . . cord-014516-r59usk02 2088 1 Interestingly interestingly RB cord-014516-r59usk02 2088 2 , , , cord-014516-r59usk02 2088 3 despite despite IN cord-014516-r59usk02 2088 4 their -PRON- PRP$ cord-014516-r59usk02 2088 5 close close JJ cord-014516-r59usk02 2088 6 genetic genetic JJ cord-014516-r59usk02 2088 7 relationship relationship NN cord-014516-r59usk02 2088 8 , , , cord-014516-r59usk02 2088 9 in in IN cord-014516-r59usk02 2088 10 humans human NNS cord-014516-r59usk02 2088 11 CU CU NNP cord-014516-r59usk02 2088 12 is be VBZ cord-014516-r59usk02 2088 13 considered consider VBN cord-014516-r59usk02 2088 14 a a DT cord-014516-r59usk02 2088 15 pathogen pathogen NN cord-014516-r59usk02 2088 16 while while IN cord-014516-r59usk02 2088 17 CH CH NNP cord-014516-r59usk02 2088 18 is be VBZ cord-014516-r59usk02 2088 19 not not RB cord-014516-r59usk02 2088 20 . . . cord-014516-r59usk02 2089 1 This this DT cord-014516-r59usk02 2089 2 study study NN cord-014516-r59usk02 2089 3 aimed aim VBD cord-014516-r59usk02 2089 4 to to TO cord-014516-r59usk02 2089 5 describe describe VB cord-014516-r59usk02 2089 6 whole whole JJ cord-014516-r59usk02 2089 7 genomes genome NNS cord-014516-r59usk02 2089 8 of of IN cord-014516-r59usk02 2089 9 CU CU NNP cord-014516-r59usk02 2089 10 and and CC cord-014516-r59usk02 2089 11 CH CH NNP cord-014516-r59usk02 2089 12 isolated isolate VBN cord-014516-r59usk02 2089 13 from from IN cord-014516-r59usk02 2089 14 dogs dog NNS cord-014516-r59usk02 2089 15 and and CC cord-014516-r59usk02 2089 16 cats cat NNS cord-014516-r59usk02 2089 17 and and CC cord-014516-r59usk02 2089 18 to to IN cord-014516-r59usk02 2089 19 in in IN cord-014516-r59usk02 2089 20 silico silico NNS cord-014516-r59usk02 2089 21 investigate investigate VBP cord-014516-r59usk02 2089 22 their -PRON- PRP$ cord-014516-r59usk02 2089 23 pathogenic pathogenic JJ cord-014516-r59usk02 2089 24 potential potential NN cord-014516-r59usk02 2089 25 with with IN cord-014516-r59usk02 2089 26 comparison comparison NN cord-014516-r59usk02 2089 27 to to IN cord-014516-r59usk02 2089 28 several several JJ cord-014516-r59usk02 2089 29 published publish VBN cord-014516-r59usk02 2089 30 genomes genome NNS cord-014516-r59usk02 2089 31 of of IN cord-014516-r59usk02 2089 32 C. C. NNP cord-014516-r59usk02 2089 33 jejuni jejuni NNP cord-014516-r59usk02 2089 34 and and CC cord-014516-r59usk02 2089 35 C. C. NNP cord-014516-r59usk02 2089 36 coli coli NNS cord-014516-r59usk02 2089 37 . . . cord-014516-r59usk02 2090 1 Genomic genomic JJ cord-014516-r59usk02 2090 2 DNA dna NN cord-014516-r59usk02 2090 3 was be VBD cord-014516-r59usk02 2090 4 extracted extract VBN cord-014516-r59usk02 2090 5 from from IN cord-014516-r59usk02 2090 6 three three CD cord-014516-r59usk02 2090 7 isolates isolate NNS cord-014516-r59usk02 2090 8 of of IN cord-014516-r59usk02 2090 9 each each DT cord-014516-r59usk02 2090 10 of of IN cord-014516-r59usk02 2090 11 CU CU NNP cord-014516-r59usk02 2090 12 and and CC cord-014516-r59usk02 2090 13 CH CH NNP cord-014516-r59usk02 2090 14 recovered recover VBD cord-014516-r59usk02 2090 15 from from IN cord-014516-r59usk02 2090 16 the the DT cord-014516-r59usk02 2090 17 faeces faece NNS cord-014516-r59usk02 2090 18 of of IN cord-014516-r59usk02 2090 19 healthy healthy JJ cord-014516-r59usk02 2090 20 dogs dog NNS cord-014516-r59usk02 2090 21 and and CC cord-014516-r59usk02 2090 22 cats cat NNS cord-014516-r59usk02 2090 23 . . . cord-014516-r59usk02 2091 1 Sequencing sequencing NN cord-014516-r59usk02 2091 2 was be VBD cord-014516-r59usk02 2091 3 performed perform VBN cord-014516-r59usk02 2091 4 using use VBG cord-014516-r59usk02 2091 5 an an DT cord-014516-r59usk02 2091 6 Illumina Illumina NNP cord-014516-r59usk02 2091 7 MiSeq MiSeq NNP cord-014516-r59usk02 2091 8 to to TO cord-014516-r59usk02 2091 9 generate generate VB cord-014516-r59usk02 2091 10 250 250 CD cord-014516-r59usk02 2091 11 base base NN cord-014516-r59usk02 2091 12 paired pair VBN cord-014516-r59usk02 2091 13 reads read VBZ cord-014516-r59usk02 2091 14 . . . cord-014516-r59usk02 2092 1 Reads read NNS cord-014516-r59usk02 2092 2 were be VBD cord-014516-r59usk02 2092 3 trimmed trim VBN cord-014516-r59usk02 2092 4 for for IN cord-014516-r59usk02 2092 5 both both DT cord-014516-r59usk02 2092 6 length length NN cord-014516-r59usk02 2092 7 and and CC cord-014516-r59usk02 2092 8 quality quality NN cord-014516-r59usk02 2092 9 . . . cord-014516-r59usk02 2093 1 Contigs Contigs NNP cord-014516-r59usk02 2093 2 were be VBD cord-014516-r59usk02 2093 3 assembled assemble VBN cord-014516-r59usk02 2093 4 using use VBG cord-014516-r59usk02 2093 5 the the DT cord-014516-r59usk02 2093 6 Velvet Velvet NNP cord-014516-r59usk02 2093 7 assembler assembler NN cord-014516-r59usk02 2093 8 . . . cord-014516-r59usk02 2094 1 The the DT cord-014516-r59usk02 2094 2 concatenated concatenate VBN cord-014516-r59usk02 2094 3 contigs contigs NN cord-014516-r59usk02 2094 4 generated generate VBN cord-014516-r59usk02 2094 5 for for IN cord-014516-r59usk02 2094 6 each each DT cord-014516-r59usk02 2094 7 assembly assembly NN cord-014516-r59usk02 2094 8 were be VBD cord-014516-r59usk02 2094 9 quality quality NN cord-014516-r59usk02 2094 10 ranked rank VBN cord-014516-r59usk02 2094 11 ( ( -LRB- cord-014516-r59usk02 2094 12 by by IN cord-014516-r59usk02 2094 13 number number NN cord-014516-r59usk02 2094 14 , , , cord-014516-r59usk02 2094 15 size size NN cord-014516-r59usk02 2094 16 , , , cord-014516-r59usk02 2094 17 maximum maximum JJ cord-014516-r59usk02 2094 18 length length NN cord-014516-r59usk02 2094 19 and and CC cord-014516-r59usk02 2094 20 N50 N50 NNP cord-014516-r59usk02 2094 21 ) ) -RRB- cord-014516-r59usk02 2094 22 and and CC cord-014516-r59usk02 2094 23 the the DT cord-014516-r59usk02 2094 24 three three CD cord-014516-r59usk02 2094 25 top top JJ cord-014516-r59usk02 2094 26 ranked rank VBN cord-014516-r59usk02 2094 27 assemblies assembly NNS cord-014516-r59usk02 2094 28 were be VBD cord-014516-r59usk02 2094 29 annotated annotate VBN cord-014516-r59usk02 2094 30 using use VBG cord-014516-r59usk02 2094 31 the the DT cord-014516-r59usk02 2094 32 Prokka Prokka NNP cord-014516-r59usk02 2094 33 annotation annotation NN cord-014516-r59usk02 2094 34 tool tool NN cord-014516-r59usk02 2094 35 . . . cord-014516-r59usk02 2095 1 Ribosomal Ribosomal NNP cord-014516-r59usk02 2095 2 MLST MLST NNP cord-014516-r59usk02 2095 3 nucleotide nucleotide JJ cord-014516-r59usk02 2095 4 sequences sequence NNS cord-014516-r59usk02 2095 5 were be VBD cord-014516-r59usk02 2095 6 used use VBN cord-014516-r59usk02 2095 7 as as IN cord-014516-r59usk02 2095 8 a a DT cord-014516-r59usk02 2095 9 proxy proxy NN cord-014516-r59usk02 2095 10 for for IN cord-014516-r59usk02 2095 11 the the DT cord-014516-r59usk02 2095 12 core core NN cord-014516-r59usk02 2095 13 genome genome NN cord-014516-r59usk02 2095 14 to to TO cord-014516-r59usk02 2095 15 compare compare VB cord-014516-r59usk02 2095 16 the the DT cord-014516-r59usk02 2095 17 phylogeny phylogeny NN cord-014516-r59usk02 2095 18 of of IN cord-014516-r59usk02 2095 19 CU CU NNP cord-014516-r59usk02 2095 20 and and CC cord-014516-r59usk02 2095 21 CH CH NNP cord-014516-r59usk02 2095 22 with with IN cord-014516-r59usk02 2095 23 other other JJ cord-014516-r59usk02 2095 24 species specie NNS cord-014516-r59usk02 2095 25 in in IN cord-014516-r59usk02 2095 26 the the DT cord-014516-r59usk02 2095 27 Campylobacter Campylobacter NNP cord-014516-r59usk02 2095 28 genus genus NN cord-014516-r59usk02 2095 29 and and CC cord-014516-r59usk02 2095 30 visualised visualise VBN cord-014516-r59usk02 2095 31 as as IN cord-014516-r59usk02 2095 32 a a DT cord-014516-r59usk02 2095 33 NeighborNet NeighborNet NNP cord-014516-r59usk02 2095 34 using use VBG cord-014516-r59usk02 2095 35 SplitsTree SplitsTree NNP cord-014516-r59usk02 2095 36 . . . cord-014516-r59usk02 2096 1 Annotated annotate VBN cord-014516-r59usk02 2096 2 draft draft NN cord-014516-r59usk02 2096 3 genomes genome NNS cord-014516-r59usk02 2096 4 were be VBD cord-014516-r59usk02 2096 5 clustered cluster VBN cord-014516-r59usk02 2096 6 using use VBG cord-014516-r59usk02 2096 7 OrthoMCL orthomcl JJ cord-014516-r59usk02 2096 8 and and CC cord-014516-r59usk02 2096 9 pathogenic pathogenic JJ cord-014516-r59usk02 2096 10 traits trait NNS cord-014516-r59usk02 2096 11 were be VBD cord-014516-r59usk02 2096 12 investigated investigate VBN cord-014516-r59usk02 2096 13 in in IN cord-014516-r59usk02 2096 14 silico silico NN cord-014516-r59usk02 2096 15 using use VBG cord-014516-r59usk02 2096 16 PathogenFinder PathogenFinder NNP cord-014516-r59usk02 2096 17 and and CC cord-014516-r59usk02 2096 18 Viru Viru NNP cord-014516-r59usk02 2096 19 - - HYPH cord-014516-r59usk02 2096 20 lentPred lentpre VBN cord-014516-r59usk02 2096 21 software software NN cord-014516-r59usk02 2096 22 . . . cord-014516-r59usk02 2097 1 The the DT cord-014516-r59usk02 2097 2 CU CU NNP cord-014516-r59usk02 2097 3 and and CC cord-014516-r59usk02 2097 4 CH CH NNP cord-014516-r59usk02 2097 5 draft draft NN cord-014516-r59usk02 2097 6 genomes genome NNS cord-014516-r59usk02 2097 7 were~1.732 were~1.732 : cord-014516-r59usk02 2097 8 Mb Mb NNS cord-014516-r59usk02 2097 9 and and CC cord-014516-r59usk02 2097 10 1.844 1.844 CD cord-014516-r59usk02 2097 11 Mb Mb NNS cord-014516-r59usk02 2097 12 in in IN cord-014516-r59usk02 2097 13 size size NN cord-014516-r59usk02 2097 14 , , , cord-014516-r59usk02 2097 15 and and CC cord-014516-r59usk02 2097 16 comprised comprise VBN cord-014516-r59usk02 2097 17 on on IN cord-014516-r59usk02 2097 18 average average JJ cord-014516-r59usk02 2097 19 110 110 CD cord-014516-r59usk02 2097 20 and and CC cord-014516-r59usk02 2097 21 151 151 CD cord-014516-r59usk02 2097 22 contigs contig NNS cord-014516-r59usk02 2097 23 , , , cord-014516-r59usk02 2097 24 and and CC cord-014516-r59usk02 2097 25 on on IN cord-014516-r59usk02 2097 26 average average JJ cord-014516-r59usk02 2097 27 1782 1782 CD cord-014516-r59usk02 2097 28 and and CC cord-014516-r59usk02 2097 29 1942 1942 CD cord-014516-r59usk02 2097 30 predicted predict VBN cord-014516-r59usk02 2097 31 genes gene NNS cord-014516-r59usk02 2097 32 , , , cord-014516-r59usk02 2097 33 respectively respectively RB cord-014516-r59usk02 2097 34 . . . cord-014516-r59usk02 2098 1 Of of IN cord-014516-r59usk02 2098 2 these these DT cord-014516-r59usk02 2098 3 CU CU NNP cord-014516-r59usk02 2098 4 had have VBD cord-014516-r59usk02 2098 5 on on IN cord-014516-r59usk02 2098 6 average average JJ cord-014516-r59usk02 2098 7 497 497 CD cord-014516-r59usk02 2098 8 and and CC cord-014516-r59usk02 2098 9 CH CH NNP cord-014516-r59usk02 2098 10 622 622 CD cord-014516-r59usk02 2098 11 hypothetical hypothetical JJ cord-014516-r59usk02 2098 12 proteins protein NNS cord-014516-r59usk02 2098 13 . . . cord-014516-r59usk02 2099 1 Using use VBG cord-014516-r59usk02 2099 2 OrthoMCL OrthoMCL NNP cord-014516-r59usk02 2099 3 , , , cord-014516-r59usk02 2099 4 a a DT cord-014516-r59usk02 2099 5 core core NN cord-014516-r59usk02 2099 6 genome genome NN cord-014516-r59usk02 2099 7 of of IN cord-014516-r59usk02 2099 8 1459 1459 CD cord-014516-r59usk02 2099 9 and and CC cord-014516-r59usk02 2099 10 1751 1751 CD cord-014516-r59usk02 2099 11 genes gene NNS cord-014516-r59usk02 2099 12 resulted result VBD cord-014516-r59usk02 2099 13 for for IN cord-014516-r59usk02 2099 14 CU CU NNP cord-014516-r59usk02 2099 15 and and CC cord-014516-r59usk02 2099 16 CH CH NNP cord-014516-r59usk02 2099 17 , , , cord-014516-r59usk02 2099 18 respectively respectively RB cord-014516-r59usk02 2099 19 . . . cord-014516-r59usk02 2100 1 NeighborNet neighbornet JJ cord-014516-r59usk02 2100 2 trees tree NNS cord-014516-r59usk02 2100 3 based base VBN cord-014516-r59usk02 2100 4 on on IN cord-014516-r59usk02 2100 5 ribosomal ribosomal JJ cord-014516-r59usk02 2100 6 MLST MLST NNP cord-014516-r59usk02 2100 7 nucleotide nucleotide JJ cord-014516-r59usk02 2100 8 sequences sequence NNS cord-014516-r59usk02 2100 9 and and CC cord-014516-r59usk02 2100 10 the the DT cord-014516-r59usk02 2100 11 core core NN cord-014516-r59usk02 2100 12 genome genome NN cord-014516-r59usk02 2100 13 confirmed confirm VBD cord-014516-r59usk02 2100 14 the the DT cord-014516-r59usk02 2100 15 close close JJ cord-014516-r59usk02 2100 16 phylogenetic phylogenetic JJ cord-014516-r59usk02 2100 17 relationship relationship NN cord-014516-r59usk02 2100 18 of of IN cord-014516-r59usk02 2100 19 CH CH NNP cord-014516-r59usk02 2100 20 and and CC cord-014516-r59usk02 2100 21 CU CU NNP cord-014516-r59usk02 2100 22 within within IN cord-014516-r59usk02 2100 23 the the DT cord-014516-r59usk02 2100 24 Campylobacter Campylobacter NNP cord-014516-r59usk02 2100 25 genus genus NN cord-014516-r59usk02 2100 26 . . . cord-014516-r59usk02 2101 1 PathogenFinder PathogenFinder NNP cord-014516-r59usk02 2101 2 predicted predict VBD cord-014516-r59usk02 2101 3 all all DT cord-014516-r59usk02 2101 4 isolates isolate NNS cord-014516-r59usk02 2101 5 as as IN cord-014516-r59usk02 2101 6 human human JJ cord-014516-r59usk02 2101 7 pathogens pathogen NNS cord-014516-r59usk02 2101 8 with with IN cord-014516-r59usk02 2101 9 probabilities probability NNS cord-014516-r59usk02 2101 10 of of IN cord-014516-r59usk02 2101 11 88.3 88.3 CD cord-014516-r59usk02 2101 12 - - HYPH cord-014516-r59usk02 2101 13 91.5 91.5 CD cord-014516-r59usk02 2101 14 % % NN cord-014516-r59usk02 2101 15 . . . cord-014516-r59usk02 2102 1 Both both CC cord-014516-r59usk02 2102 2 PathogenFinder PathogenFinder NNP cord-014516-r59usk02 2102 3 and and CC cord-014516-r59usk02 2102 4 VirulentPred VirulentPred NNP cord-014516-r59usk02 2102 5 identified identify VBD cord-014516-r59usk02 2102 6 many many JJ cord-014516-r59usk02 2102 7 pathogenic pathogenic JJ cord-014516-r59usk02 2102 8 proteins protein NNS cord-014516-r59usk02 2102 9 in in IN cord-014516-r59usk02 2102 10 CU CU NNP cord-014516-r59usk02 2102 11 and and CC cord-014516-r59usk02 2102 12 CH CH NNP cord-014516-r59usk02 2102 13 of of IN cord-014516-r59usk02 2102 14 different different JJ cord-014516-r59usk02 2102 15 functions function NNS cord-014516-r59usk02 2102 16 ( ( -LRB- cord-014516-r59usk02 2102 17 e.g. e.g. IN cord-014516-r59usk02 2102 18 chemotaxis chemotaxis NN cord-014516-r59usk02 2102 19 , , , cord-014516-r59usk02 2102 20 transporter transporter NN cord-014516-r59usk02 2102 21 and and CC cord-014516-r59usk02 2102 22 motility motility NN cord-014516-r59usk02 2102 23 systems system NNS cord-014516-r59usk02 2102 24 ) ) -RRB- cord-014516-r59usk02 2102 25 but but CC cord-014516-r59usk02 2102 26 considerably considerably RB cord-014516-r59usk02 2102 27 fewer few JJR cord-014516-r59usk02 2102 28 than than IN cord-014516-r59usk02 2102 29 in in IN cord-014516-r59usk02 2102 30 C. C. NNP cord-014516-r59usk02 2102 31 jejuni jejuni NNP cord-014516-r59usk02 2102 32 and and CC cord-014516-r59usk02 2102 33 C. C. NNP cord-014516-r59usk02 2102 34 coli coli NNS cord-014516-r59usk02 2102 35 . . . cord-014516-r59usk02 2103 1 This this DT cord-014516-r59usk02 2103 2 study study NN cord-014516-r59usk02 2103 3 provides provide VBZ cord-014516-r59usk02 2103 4 many many JJ cord-014516-r59usk02 2103 5 insights insight NNS cord-014516-r59usk02 2103 6 into into IN cord-014516-r59usk02 2103 7 the the DT cord-014516-r59usk02 2103 8 pathogenic pathogenic JJ cord-014516-r59usk02 2103 9 potential potential NN cord-014516-r59usk02 2103 10 of of IN cord-014516-r59usk02 2103 11 pet pet JJ cord-014516-r59usk02 2103 12 - - HYPH cord-014516-r59usk02 2103 13 associated associate VBN cord-014516-r59usk02 2103 14 emerging emerge VBG cord-014516-r59usk02 2103 15 Campylobacter Campylobacter NNP cord-014516-r59usk02 2103 16 pathogens pathogen NNS cord-014516-r59usk02 2103 17 and and CC cord-014516-r59usk02 2103 18 is be VBZ cord-014516-r59usk02 2103 19 to to IN cord-014516-r59usk02 2103 20 our -PRON- PRP$ cord-014516-r59usk02 2103 21 knowledge knowledge NN cord-014516-r59usk02 2103 22 , , , cord-014516-r59usk02 2103 23 the the DT cord-014516-r59usk02 2103 24 first first JJ cord-014516-r59usk02 2103 25 to to TO cord-014516-r59usk02 2103 26 report report VB cord-014516-r59usk02 2103 27 a a DT cord-014516-r59usk02 2103 28 draft draft NN cord-014516-r59usk02 2103 29 genome genome NN cord-014516-r59usk02 2103 30 of of IN cord-014516-r59usk02 2103 31 CH CH NNP cord-014516-r59usk02 2103 32 . . . cord-014516-r59usk02 2104 1 No no DT cord-014516-r59usk02 2104 2 conflicts conflict NNS cord-014516-r59usk02 2104 3 of of IN cord-014516-r59usk02 2104 4 interest interest NN cord-014516-r59usk02 2104 5 reported report VBN cord-014516-r59usk02 2104 6 . . . cord-014516-r59usk02 2105 1 There there EX cord-014516-r59usk02 2105 2 are be VBP cord-014516-r59usk02 2105 3 only only RB cord-014516-r59usk02 2105 4 few few JJ cord-014516-r59usk02 2105 5 laboratory laboratory NN cord-014516-r59usk02 2105 6 markers marker NNS cord-014516-r59usk02 2105 7 being be VBG cord-014516-r59usk02 2105 8 evaluated evaluate VBN cord-014516-r59usk02 2105 9 for for IN cord-014516-r59usk02 2105 10 diagnosing diagnose VBG cord-014516-r59usk02 2105 11 and/or and/or CC cord-014516-r59usk02 2105 12 monitoring monitor VBG cord-014516-r59usk02 2105 13 canine canine JJ cord-014516-r59usk02 2105 14 chronic chronic JJ cord-014516-r59usk02 2105 15 enteropathies enteropathy NNS cord-014516-r59usk02 2105 16 , , , cord-014516-r59usk02 2105 17 including include VBG cord-014516-r59usk02 2105 18 inflammatory inflammatory JJ cord-014516-r59usk02 2105 19 bowel bowel NN cord-014516-r59usk02 2105 20 disease disease NN cord-014516-r59usk02 2105 21 ( ( -LRB- cord-014516-r59usk02 2105 22 IBD IBD NNP cord-014516-r59usk02 2105 23 ) ) -RRB- cord-014516-r59usk02 2105 24 . . . cord-014516-r59usk02 2106 1 S100A12 s100a12 NN cord-014516-r59usk02 2106 2 belongs belong VBZ cord-014516-r59usk02 2106 3 to to IN cord-014516-r59usk02 2106 4 the the DT cord-014516-r59usk02 2106 5 S100 S100 NNP cord-014516-r59usk02 2106 6 / / SYM cord-014516-r59usk02 2106 7 calgranulin calgranulin NN cord-014516-r59usk02 2106 8 - - HYPH cord-014516-r59usk02 2106 9 protein protein NN cord-014516-r59usk02 2106 10 family family NN cord-014516-r59usk02 2106 11 and and CC cord-014516-r59usk02 2106 12 has have VBZ cord-014516-r59usk02 2106 13 been be VBN cord-014516-r59usk02 2106 14 proposed propose VBN cord-014516-r59usk02 2106 15 to to TO cord-014516-r59usk02 2106 16 play play VB cord-014516-r59usk02 2106 17 a a DT cord-014516-r59usk02 2106 18 central central JJ cord-014516-r59usk02 2106 19 role role NN cord-014516-r59usk02 2106 20 in in IN cord-014516-r59usk02 2106 21 both both DT cord-014516-r59usk02 2106 22 innate innate JJ cord-014516-r59usk02 2106 23 and and CC cord-014516-r59usk02 2106 24 acquired acquire VBD cord-014516-r59usk02 2106 25 immune immune JJ cord-014516-r59usk02 2106 26 responses response NNS cord-014516-r59usk02 2106 27 . . . cord-014516-r59usk02 2107 1 It -PRON- PRP cord-014516-r59usk02 2107 2 has have VBZ cord-014516-r59usk02 2107 3 been be VBN cord-014516-r59usk02 2107 4 reported report VBN cord-014516-r59usk02 2107 5 to to TO cord-014516-r59usk02 2107 6 be be VB cord-014516-r59usk02 2107 7 increased increase VBN cord-014516-r59usk02 2107 8 in in IN cord-014516-r59usk02 2107 9 stool stool NN cord-014516-r59usk02 2107 10 samples sample NNS cord-014516-r59usk02 2107 11 , , , cord-014516-r59usk02 2107 12 serum serum NN cord-014516-r59usk02 2107 13 and/or and/or CC cord-014516-r59usk02 2107 14 intestinal intestinal JJ cord-014516-r59usk02 2107 15 mucosa mucosa NN cord-014516-r59usk02 2107 16 in in IN cord-014516-r59usk02 2107 17 human human JJ cord-014516-r59usk02 2107 18 patients patient NNS cord-014516-r59usk02 2107 19 with with IN cord-014516-r59usk02 2107 20 IBD IBD NNP cord-014516-r59usk02 2107 21 . . . cord-014516-r59usk02 2108 1 Myeloperoxidase Myeloperoxidase NNP cord-014516-r59usk02 2108 2 ( ( -LRB- cord-014516-r59usk02 2108 3 MPO MPO NNP cord-014516-r59usk02 2108 4 ) ) -RRB- cord-014516-r59usk02 2108 5 is be VBZ cord-014516-r59usk02 2108 6 an an DT cord-014516-r59usk02 2108 7 enzyme enzyme NN cord-014516-r59usk02 2108 8 found find VBN cord-014516-r59usk02 2108 9 mostly mostly RB cord-014516-r59usk02 2108 10 in in IN cord-014516-r59usk02 2108 11 granulocytes granulocyte NNS cord-014516-r59usk02 2108 12 . . . cord-014516-r59usk02 2109 1 Intestinal intestinal JJ cord-014516-r59usk02 2109 2 mucosal mucosal JJ cord-014516-r59usk02 2109 3 levels level NNS cord-014516-r59usk02 2109 4 of of IN cord-014516-r59usk02 2109 5 MPO MPO NNP cord-014516-r59usk02 2109 6 have have VBP cord-014516-r59usk02 2109 7 been be VBN cord-014516-r59usk02 2109 8 shown show VBN cord-014516-r59usk02 2109 9 to to TO cord-014516-r59usk02 2109 10 be be VB cord-014516-r59usk02 2109 11 increased increase VBN cord-014516-r59usk02 2109 12 in in IN cord-014516-r59usk02 2109 13 animal animal NN cord-014516-r59usk02 2109 14 models model NNS cord-014516-r59usk02 2109 15 and and CC cord-014516-r59usk02 2109 16 human human JJ cord-014516-r59usk02 2109 17 IBD IBD NNP cord-014516-r59usk02 2109 18 . . . cord-014516-r59usk02 2110 1 To to IN cord-014516-r59usk02 2110 2 date date NN cord-014516-r59usk02 2110 3 , , , cord-014516-r59usk02 2110 4 S100A12 s100a12 NN cord-014516-r59usk02 2110 5 and and CC cord-014516-r59usk02 2110 6 MPO MPO NNP cord-014516-r59usk02 2110 7 levels level NNS cord-014516-r59usk02 2110 8 in in IN cord-014516-r59usk02 2110 9 intestinal intestinal JJ cord-014516-r59usk02 2110 10 mucosal mucosal JJ cord-014516-r59usk02 2110 11 samples sample NNS cord-014516-r59usk02 2110 12 have have VBP cord-014516-r59usk02 2110 13 been be VBN cord-014516-r59usk02 2110 14 reported report VBN cord-014516-r59usk02 2110 15 neither neither CC cord-014516-r59usk02 2110 16 from from IN cord-014516-r59usk02 2110 17 healthy healthy JJ cord-014516-r59usk02 2110 18 dogs dog NNS cord-014516-r59usk02 2110 19 nor nor CC cord-014516-r59usk02 2110 20 from from IN cord-014516-r59usk02 2110 21 dogs dog NNS cord-014516-r59usk02 2110 22 suffering suffer VBG cord-014516-r59usk02 2110 23 from from IN cord-014516-r59usk02 2110 24 IBD IBD NNP cord-014516-r59usk02 2110 25 . . . cord-014516-r59usk02 2111 1 To to TO cord-014516-r59usk02 2111 2 start start VB cord-014516-r59usk02 2111 3 investigating investigate VBG cord-014516-r59usk02 2111 4 this this DT cord-014516-r59usk02 2111 5 aspect aspect NN cord-014516-r59usk02 2111 6 in in IN cord-014516-r59usk02 2111 7 dogs dog NNS cord-014516-r59usk02 2111 8 , , , cord-014516-r59usk02 2111 9 the the DT cord-014516-r59usk02 2111 10 objective objective NN cord-014516-r59usk02 2111 11 of of IN cord-014516-r59usk02 2111 12 this this DT cord-014516-r59usk02 2111 13 study study NN cord-014516-r59usk02 2111 14 was be VBD cord-014516-r59usk02 2111 15 to to TO cord-014516-r59usk02 2111 16 evaluate evaluate VB cord-014516-r59usk02 2111 17 mucosal mucosal JJ cord-014516-r59usk02 2111 18 S100A12 s100a12 NN cord-014516-r59usk02 2111 19 and and CC cord-014516-r59usk02 2111 20 MPO MPO NNP cord-014516-r59usk02 2111 21 levels level NNS cord-014516-r59usk02 2111 22 in in IN cord-014516-r59usk02 2111 23 the the DT cord-014516-r59usk02 2111 24 small small JJ cord-014516-r59usk02 2111 25 and and CC cord-014516-r59usk02 2111 26 large large JJ cord-014516-r59usk02 2111 27 intestines intestine NNS cord-014516-r59usk02 2111 28 by by IN cord-014516-r59usk02 2111 29 using use VBG cord-014516-r59usk02 2111 30 enzyme enzyme NN cord-014516-r59usk02 2111 31 - - HYPH cord-014516-r59usk02 2111 32 linked link VBN cord-014516-r59usk02 2111 33 immunoassay immunoassay NN cord-014516-r59usk02 2111 34 ( ( -LRB- cord-014516-r59usk02 2111 35 ELISA ELISA NNP cord-014516-r59usk02 2111 36 ) ) -RRB- cord-014516-r59usk02 2111 37 and and CC cord-014516-r59usk02 2111 38 spectrophotometric spectrophotometric JJ cord-014516-r59usk02 2111 39 methods method NNS cord-014516-r59usk02 2111 40 , , , cord-014516-r59usk02 2111 41 respectively respectively RB cord-014516-r59usk02 2111 42 . . . cord-014516-r59usk02 2112 1 For for IN cord-014516-r59usk02 2112 2 the the DT cord-014516-r59usk02 2112 3 study study NN cord-014516-r59usk02 2112 4 , , , cord-014516-r59usk02 2112 5 historical historical JJ cord-014516-r59usk02 2112 6 intestinal intestinal JJ cord-014516-r59usk02 2112 7 tissue tissue NN cord-014516-r59usk02 2112 8 samples sample NNS cord-014516-r59usk02 2112 9 from from IN cord-014516-r59usk02 2112 10 four four CD cord-014516-r59usk02 2112 11 different different JJ cord-014516-r59usk02 2112 12 parts part NNS cord-014516-r59usk02 2112 13 of of IN cord-014516-r59usk02 2112 14 the the DT cord-014516-r59usk02 2112 15 intestine intestine NN cord-014516-r59usk02 2112 16 ( ( -LRB- cord-014516-r59usk02 2112 17 duodenum duodenum NN cord-014516-r59usk02 2112 18 , , , cord-014516-r59usk02 2112 19 jejunum jejunum NNS cord-014516-r59usk02 2112 20 , , , cord-014516-r59usk02 2112 21 ileum ileum NN cord-014516-r59usk02 2112 22 and and CC cord-014516-r59usk02 2112 23 colon colon NN cord-014516-r59usk02 2112 24 ) ) -RRB- cord-014516-r59usk02 2112 25 were be VBD cord-014516-r59usk02 2112 26 used use VBN cord-014516-r59usk02 2112 27 . . . cord-014516-r59usk02 2113 1 The the DT cord-014516-r59usk02 2113 2 samples sample NNS cord-014516-r59usk02 2113 3 were be VBD cord-014516-r59usk02 2113 4 taken take VBN cord-014516-r59usk02 2113 5 and and CC cord-014516-r59usk02 2113 6 snap snap VB cord-014516-r59usk02 2113 7 frozen freeze VBN cord-014516-r59usk02 2113 8 in in IN cord-014516-r59usk02 2113 9 liquid liquid JJ cord-014516-r59usk02 2113 10 nitrogen nitrogen NN cord-014516-r59usk02 2113 11 during during IN cord-014516-r59usk02 2113 12 necropsy necropsy JJ cord-014516-r59usk02 2113 13 from from IN cord-014516-r59usk02 2113 14 12 12 CD cord-014516-r59usk02 2113 15 healthy healthy JJ cord-014516-r59usk02 2113 16 laboratory laboratory NN cord-014516-r59usk02 2113 17 beagle beagle NN cord-014516-r59usk02 2113 18 dogs dog NNS cord-014516-r59usk02 2113 19 after after IN cord-014516-r59usk02 2113 20 being be VBG cord-014516-r59usk02 2113 21 euthanized euthanize VBN cord-014516-r59usk02 2113 22 when when WRB cord-014516-r59usk02 2113 23 finishing finish VBG cord-014516-r59usk02 2113 24 unrelated unrelated JJ cord-014516-r59usk02 2113 25 long long JJ cord-014516-r59usk02 2113 26 - - HYPH cord-014516-r59usk02 2113 27 term term NN cord-014516-r59usk02 2113 28 trials trial NNS cord-014516-r59usk02 2113 29 studying study VBG cord-014516-r59usk02 2113 30 canine canine JJ cord-014516-r59usk02 2113 31 intestinal intestinal JJ cord-014516-r59usk02 2113 32 microbiota microbiota NN cord-014516-r59usk02 2113 33 . . . cord-014516-r59usk02 2114 1 Based base VBN cord-014516-r59usk02 2114 2 on on IN cord-014516-r59usk02 2114 3 WSAVA WSAVA NNP cord-014516-r59usk02 2114 4 standards standard NNS cord-014516-r59usk02 2115 1 the the DT cord-014516-r59usk02 2115 2 histologic histologic JJ cord-014516-r59usk02 2115 3 findings finding NNS cord-014516-r59usk02 2115 4 of of IN cord-014516-r59usk02 2115 5 all all DT cord-014516-r59usk02 2115 6 samples sample NNS cord-014516-r59usk02 2115 7 were be VBD cord-014516-r59usk02 2115 8 considered consider VBN cord-014516-r59usk02 2115 9 insignificant insignificant JJ cord-014516-r59usk02 2115 10 . . . cord-014516-r59usk02 2116 1 S100A12 s100a12 NN cord-014516-r59usk02 2116 2 concentrations concentration NNS cord-014516-r59usk02 2116 3 were be VBD cord-014516-r59usk02 2116 4 from from IN cord-014516-r59usk02 2116 5 the the DT cord-014516-r59usk02 2116 6 highest high JJS cord-014516-r59usk02 2116 7 to to IN cord-014516-r59usk02 2116 8 the the DT cord-014516-r59usk02 2116 9 lowest low JJS cord-014516-r59usk02 2116 10 : : : cord-014516-r59usk02 2116 11 ileum ileum NN cord-014516-r59usk02 2116 12 , , , cord-014516-r59usk02 2116 13 71.5 71.5 CD cord-014516-r59usk02 2116 14 ( ( -LRB- cord-014516-r59usk02 2116 15 38.9 38.9 CD cord-014516-r59usk02 2116 16 - - HYPH cord-014516-r59usk02 2116 17 141.9 141.9 CD cord-014516-r59usk02 2116 18 ) ) -RRB- cord-014516-r59usk02 2116 19 lg lg NNP cord-014516-r59usk02 2116 20 / / SYM cord-014516-r59usk02 2116 21 L l NN cord-014516-r59usk02 2116 22 ; ; : cord-014516-r59usk02 2116 23 colon colon NN cord-014516-r59usk02 2116 24 , , , cord-014516-r59usk02 2116 25 23.2 23.2 CD cord-014516-r59usk02 2116 26 ( ( -LRB- cord-014516-r59usk02 2116 27 6.7 6.7 CD cord-014516-r59usk02 2116 28 - - SYM cord-014516-r59usk02 2116 29 75.6 75.6 CD cord-014516-r59usk02 2116 30 ) ) -RRB- cord-014516-r59usk02 2116 31 lg lg NNP cord-014516-r59usk02 2116 32 / / SYM cord-014516-r59usk02 2116 33 L l NN cord-014516-r59usk02 2116 34 ; ; : cord-014516-r59usk02 2116 35 duodenum duodenum NN cord-014516-r59usk02 2116 36 , , , cord-014516-r59usk02 2116 37 11.4 11.4 CD cord-014516-r59usk02 2116 38 ( ( -LRB- cord-014516-r59usk02 2116 39 6.9 6.9 CD cord-014516-r59usk02 2116 40 - - SYM cord-014516-r59usk02 2116 41 28.5 28.5 CD cord-014516-r59usk02 2116 42 ) ) -RRB- cord-014516-r59usk02 2116 43 lg lg NNP cord-014516-r59usk02 2116 44 / / SYM cord-014516-r59usk02 2116 45 L L NNP cord-014516-r59usk02 2116 46 ; ; : cord-014516-r59usk02 2116 47 and and CC cord-014516-r59usk02 2116 48 jejunum jejunum NNS cord-014516-r59usk02 2116 49 , , , cord-014516-r59usk02 2116 50 8.5 8.5 CD cord-014516-r59usk02 2116 51 ( ( -LRB- cord-014516-r59usk02 2116 52 5.1 5.1 CD cord-014516-r59usk02 2116 53 - - SYM cord-014516-r59usk02 2116 54 19.3 19.3 CD cord-014516-r59usk02 2116 55 ) ) -RRB- cord-014516-r59usk02 2116 56 lg lg NNP cord-014516-r59usk02 2116 57 / / SYM cord-014516-r59usk02 2116 58 L. L. NNP cord-014516-r59usk02 2117 1 The the DT cord-014516-r59usk02 2117 2 concentration concentration NN cord-014516-r59usk02 2117 3 in in IN cord-014516-r59usk02 2117 4 the the DT cord-014516-r59usk02 2117 5 ileum ileum NN cord-014516-r59usk02 2117 6 was be VBD cord-014516-r59usk02 2117 7 significantly significantly RB cord-014516-r59usk02 2117 8 higher high JJR cord-014516-r59usk02 2117 9 than than IN cord-014516-r59usk02 2117 10 in in IN cord-014516-r59usk02 2117 11 all all DT cord-014516-r59usk02 2117 12 other other JJ cord-014516-r59usk02 2117 13 segments segment NNS cord-014516-r59usk02 2117 14 ( ( -LRB- cord-014516-r59usk02 2117 15 P p NN cord-014516-r59usk02 2117 16 < < XX cord-014516-r59usk02 2117 17 0.05 0.05 CD cord-014516-r59usk02 2117 18 ) ) -RRB- cord-014516-r59usk02 2117 19 , , , cord-014516-r59usk02 2117 20 and and CC cord-014516-r59usk02 2117 21 the the DT cord-014516-r59usk02 2117 22 colonic colonic JJ cord-014516-r59usk02 2117 23 mucosal mucosal JJ cord-014516-r59usk02 2117 24 concentration concentration NN cord-014516-r59usk02 2117 25 was be VBD cord-014516-r59usk02 2117 26 higher high JJR cord-014516-r59usk02 2117 27 than than IN cord-014516-r59usk02 2117 28 the the DT cord-014516-r59usk02 2117 29 jejunal jejunal NNP cord-014516-r59usk02 2117 30 ( ( -LRB- cord-014516-r59usk02 2117 31 P p NN cord-014516-r59usk02 2117 32 < < XX cord-014516-r59usk02 2117 33 0.05 0.05 CD cord-014516-r59usk02 2117 34 ) ) -RRB- cord-014516-r59usk02 2117 35 . . . cord-014516-r59usk02 2118 1 The the DT cord-014516-r59usk02 2118 2 highest high JJS cord-014516-r59usk02 2118 3 MPO MPO NNP cord-014516-r59usk02 2118 4 activity activity NN cord-014516-r59usk02 2118 5 was be VBD cord-014516-r59usk02 2118 6 found find VBN cord-014516-r59usk02 2118 7 in in IN cord-014516-r59usk02 2118 8 the the DT cord-014516-r59usk02 2118 9 ileum ileum NN cord-014516-r59usk02 2118 10 ( ( -LRB- cord-014516-r59usk02 2118 11 0.49 0.49 CD cord-014516-r59usk02 2118 12 [ [ -LRB- cord-014516-r59usk02 2118 13 0.19 0.19 CD cord-014516-r59usk02 2118 14 - - SYM cord-014516-r59usk02 2118 15 1.05 1.05 CD cord-014516-r59usk02 2118 16 ] ] -RRB- cord-014516-r59usk02 2118 17 DA DA NNP cord-014516-r59usk02 2118 18 / / SYM cord-014516-r59usk02 2118 19 min min NNP cord-014516-r59usk02 2118 20 ) ) -RRB- cord-014516-r59usk02 2118 21 , , , cord-014516-r59usk02 2118 22 followed follow VBN cord-014516-r59usk02 2118 23 by by IN cord-014516-r59usk02 2118 24 jejunum jejunum NNS cord-014516-r59usk02 2118 25 ( ( -LRB- cord-014516-r59usk02 2118 26 0.36 0.36 CD cord-014516-r59usk02 2118 27 [ [ -LRB- cord-014516-r59usk02 2118 28 0.28 0.28 CD cord-014516-r59usk02 2118 29 - - SYM cord-014516-r59usk02 2118 30 1.70 1.70 CD cord-014516-r59usk02 2118 31 ] ] -RRB- cord-014516-r59usk02 2118 32 DA DA NNP cord-014516-r59usk02 2118 33 / / SYM cord-014516-r59usk02 2118 34 min min NNP cord-014516-r59usk02 2118 35 ) ) -RRB- cord-014516-r59usk02 2118 36 , , , cord-014516-r59usk02 2118 37 duodenum duodenum NN cord-014516-r59usk02 2118 38 ( ( -LRB- cord-014516-r59usk02 2118 39 0.26 0.26 CD cord-014516-r59usk02 2118 40 [ [ -LRB- cord-014516-r59usk02 2118 41 0.09 0.09 CD cord-014516-r59usk02 2118 42 - - HYPH cord-014516-r59usk02 2118 43 0.59 0.59 CD cord-014516-r59usk02 2118 44 ] ] -RRB- cord-014516-r59usk02 2118 45 DA DA NNP cord-014516-r59usk02 2118 46 / / SYM cord-014516-r59usk02 2118 47 min min NNP cord-014516-r59usk02 2118 48 ) ) -RRB- cord-014516-r59usk02 2118 49 , , , cord-014516-r59usk02 2118 50 and and CC cord-014516-r59usk02 2118 51 colon colon NN cord-014516-r59usk02 2118 52 ( ( -LRB- cord-014516-r59usk02 2118 53 0.09 0.09 CD cord-014516-r59usk02 2118 54 [ [ -LRB- cord-014516-r59usk02 2118 55 0.04 0.04 CD cord-014516-r59usk02 2118 56 - - SYM cord-014516-r59usk02 2118 57 0.14 0.14 CD cord-014516-r59usk02 2118 58 ] ] -RRB- cord-014516-r59usk02 2118 59 DA DA NNP cord-014516-r59usk02 2118 60 / / SYM cord-014516-r59usk02 2118 61 min min NN cord-014516-r59usk02 2118 62 ) ) -RRB- cord-014516-r59usk02 2118 63 . . . cord-014516-r59usk02 2119 1 MPO MPO NNP cord-014516-r59usk02 2119 2 activity activity NN cord-014516-r59usk02 2119 3 was be VBD cord-014516-r59usk02 2119 4 significantly significantly RB cord-014516-r59usk02 2119 5 higher high JJR cord-014516-r59usk02 2119 6 in in IN cord-014516-r59usk02 2119 7 ileal ileal JJ cord-014516-r59usk02 2119 8 and and CC cord-014516-r59usk02 2119 9 duodenal duodenal JJ cord-014516-r59usk02 2119 10 than than IN cord-014516-r59usk02 2119 11 in in IN cord-014516-r59usk02 2119 12 colonic colonic JJ cord-014516-r59usk02 2119 13 mucosal mucosal JJ cord-014516-r59usk02 2119 14 samples sample NNS cord-014516-r59usk02 2119 15 ( ( -LRB- cord-014516-r59usk02 2119 16 P p NN cord-014516-r59usk02 2119 17 < < XX cord-014516-r59usk02 2119 18 0.05 0.05 CD cord-014516-r59usk02 2119 19 ) ) -RRB- cord-014516-r59usk02 2119 20 . . . cord-014516-r59usk02 2120 1 The the DT cord-014516-r59usk02 2120 2 jejunal jejunal JJ cord-014516-r59usk02 2120 3 MPO MPO NNP cord-014516-r59usk02 2120 4 activity activity NN cord-014516-r59usk02 2120 5 was be VBD cord-014516-r59usk02 2120 6 higher high JJR cord-014516-r59usk02 2120 7 than than IN cord-014516-r59usk02 2120 8 the the DT cord-014516-r59usk02 2120 9 colonic colonic JJ cord-014516-r59usk02 2120 10 and and CC cord-014516-r59usk02 2120 11 duodenal duodenal JJ cord-014516-r59usk02 2120 12 activity activity NN cord-014516-r59usk02 2120 13 ( ( -LRB- cord-014516-r59usk02 2120 14 P p NN cord-014516-r59usk02 2120 15 < < XX cord-014516-r59usk02 2120 16 0.05 0.05 CD cord-014516-r59usk02 2120 17 ) ) -RRB- cord-014516-r59usk02 2120 18 . . . cord-014516-r59usk02 2121 1 This this DT cord-014516-r59usk02 2121 2 study study NN cord-014516-r59usk02 2121 3 showed show VBD cord-014516-r59usk02 2121 4 that that IN cord-014516-r59usk02 2121 5 using use VBG cord-014516-r59usk02 2121 6 ELISA ELISA NNP cord-014516-r59usk02 2121 7 and and CC cord-014516-r59usk02 2121 8 spectrophotometry spectrophotometry NN cord-014516-r59usk02 2121 9 allow allow VBP cord-014516-r59usk02 2121 10 the the DT cord-014516-r59usk02 2121 11 detection detection NN cord-014516-r59usk02 2121 12 of of IN cord-014516-r59usk02 2121 13 canine canine JJ cord-014516-r59usk02 2121 14 intestinal intestinal JJ cord-014516-r59usk02 2121 15 mucosal mucosal NN cord-014516-r59usk02 2121 16 S100A12 S100A12 NNP cord-014516-r59usk02 2121 17 and and CC cord-014516-r59usk02 2121 18 MPO MPO NNP cord-014516-r59usk02 2121 19 , , , cord-014516-r59usk02 2121 20 respectively respectively RB cord-014516-r59usk02 2121 21 . . . cord-014516-r59usk02 2122 1 The the DT cord-014516-r59usk02 2122 2 levels level NNS cord-014516-r59usk02 2122 3 on on IN cord-014516-r59usk02 2122 4 S100A12 s100a12 NN cord-014516-r59usk02 2122 5 and and CC cord-014516-r59usk02 2122 6 MPO MPO NNP cord-014516-r59usk02 2122 7 seem seem VBP cord-014516-r59usk02 2122 8 to to TO cord-014516-r59usk02 2122 9 differ differ VB cord-014516-r59usk02 2122 10 between between IN cord-014516-r59usk02 2122 11 certain certain JJ cord-014516-r59usk02 2122 12 parts part NNS cord-014516-r59usk02 2122 13 of of IN cord-014516-r59usk02 2122 14 the the DT cord-014516-r59usk02 2122 15 intestinal intestinal JJ cord-014516-r59usk02 2122 16 mucosa mucosa NN cord-014516-r59usk02 2122 17 of of IN cord-014516-r59usk02 2122 18 healthy healthy JJ cord-014516-r59usk02 2122 19 dogs dog NNS cord-014516-r59usk02 2122 20 . . . cord-014516-r59usk02 2123 1 Both both DT cord-014516-r59usk02 2123 2 assays assay NNS cord-014516-r59usk02 2123 3 appear appear VBP cord-014516-r59usk02 2123 4 to to TO cord-014516-r59usk02 2123 5 be be VB cord-014516-r59usk02 2123 6 useful useful JJ cord-014516-r59usk02 2123 7 to to TO cord-014516-r59usk02 2123 8 further further RB cord-014516-r59usk02 2123 9 evaluate evaluate VB cord-014516-r59usk02 2123 10 the the DT cord-014516-r59usk02 2123 11 role role NN cord-014516-r59usk02 2123 12 of of IN cord-014516-r59usk02 2123 13 S100A12 s100a12 NN cord-014516-r59usk02 2123 14 and and CC cord-014516-r59usk02 2123 15 MPO MPO NNP cord-014516-r59usk02 2123 16 in in IN cord-014516-r59usk02 2123 17 the the DT cord-014516-r59usk02 2123 18 pathogenesis pathogenesis NN cord-014516-r59usk02 2123 19 of of IN cord-014516-r59usk02 2123 20 canine canine JJ cord-014516-r59usk02 2123 21 chronic chronic JJ cord-014516-r59usk02 2123 22 enteropathies enteropathy NNS cord-014516-r59usk02 2123 23 , , , cord-014516-r59usk02 2123 24 including include VBG cord-014516-r59usk02 2123 25 IBD IBD NNP cord-014516-r59usk02 2123 26 . . . cord-014516-r59usk02 2124 1 Dr. Dr. NNP cord-014516-r59usk02 2124 2 Heilmann Heilmann NNP cord-014516-r59usk02 2124 3 , , , cord-014516-r59usk02 2124 4 Dr. Dr. NNP cord-014516-r59usk02 2124 5 Suchodolski Suchodolski NNP cord-014516-r59usk02 2124 6 , , , cord-014516-r59usk02 2124 7 and and CC cord-014516-r59usk02 2124 8 Dr. Dr. NNP cord-014516-r59usk02 2124 9 Steiner Steiner NNP cord-014516-r59usk02 2124 10 have have VBP cord-014516-r59usk02 2124 11 a a DT cord-014516-r59usk02 2124 12 patent patent NN cord-014516-r59usk02 2124 13 pending pending NN cord-014516-r59usk02 2124 14 that that WDT cord-014516-r59usk02 2124 15 includes include VBZ cord-014516-r59usk02 2124 16 the the DT cord-014516-r59usk02 2124 17 canine canine JJ cord-014516-r59usk02 2124 18 S100A12 s100a12 NN cord-014516-r59usk02 2124 19 assay assay NN cord-014516-r59usk02 2124 20 used use VBN cord-014516-r59usk02 2124 21 in in IN cord-014516-r59usk02 2124 22 this this DT cord-014516-r59usk02 2124 23 study study NN cord-014516-r59usk02 2124 24 . . . cord-014516-r59usk02 2125 1 The the DT cord-014516-r59usk02 2125 2 authors author NNS cord-014516-r59usk02 2125 3 declare declare VBP cord-014516-r59usk02 2125 4 that that IN cord-014516-r59usk02 2125 5 they -PRON- PRP cord-014516-r59usk02 2125 6 have have VBP cord-014516-r59usk02 2125 7 no no DT cord-014516-r59usk02 2125 8 further further JJ cord-014516-r59usk02 2125 9 conflicts conflict NNS cord-014516-r59usk02 2125 10 of of IN cord-014516-r59usk02 2125 11 interest interest NN cord-014516-r59usk02 2125 12 . . . cord-014516-r59usk02 2126 1 The the DT cord-014516-r59usk02 2126 2 aim aim NN cord-014516-r59usk02 2126 3 of of IN cord-014516-r59usk02 2126 4 the the DT cord-014516-r59usk02 2126 5 present present JJ cord-014516-r59usk02 2126 6 study study NN cord-014516-r59usk02 2126 7 was be VBD cord-014516-r59usk02 2126 8 to to TO cord-014516-r59usk02 2126 9 establish establish VB cord-014516-r59usk02 2126 10 the the DT cord-014516-r59usk02 2126 11 incidence incidence NN cord-014516-r59usk02 2126 12 of of IN cord-014516-r59usk02 2126 13 innocent innocent JJ cord-014516-r59usk02 2126 14 cardiac cardiac JJ cord-014516-r59usk02 2126 15 murmurs murmur NNS cord-014516-r59usk02 2126 16 in in IN cord-014516-r59usk02 2126 17 a a DT cord-014516-r59usk02 2126 18 fairly fairly RB cord-014516-r59usk02 2126 19 large large JJ cord-014516-r59usk02 2126 20 number number NN cord-014516-r59usk02 2126 21 of of IN cord-014516-r59usk02 2126 22 clinically clinically RB cord-014516-r59usk02 2126 23 healthy healthy JJ cord-014516-r59usk02 2126 24 puppies puppy NNS cord-014516-r59usk02 2126 25 . . . cord-014516-r59usk02 2127 1 A a DT cord-014516-r59usk02 2127 2 second second JJ cord-014516-r59usk02 2127 3 aim aim NN cord-014516-r59usk02 2127 4 was be VBD cord-014516-r59usk02 2127 5 to to TO cord-014516-r59usk02 2127 6 evaluate evaluate VB cord-014516-r59usk02 2127 7 a a DT cord-014516-r59usk02 2127 8 possible possible JJ cord-014516-r59usk02 2127 9 correlation correlation NN cord-014516-r59usk02 2127 10 between between IN cord-014516-r59usk02 2127 11 the the DT cord-014516-r59usk02 2127 12 presence presence NN cord-014516-r59usk02 2127 13 of of IN cord-014516-r59usk02 2127 14 an an DT cord-014516-r59usk02 2127 15 innocent innocent JJ cord-014516-r59usk02 2127 16 cardiac cardiac JJ cord-014516-r59usk02 2127 17 murmur murmur NN cord-014516-r59usk02 2127 18 and and CC cord-014516-r59usk02 2127 19 a a DT cord-014516-r59usk02 2127 20 lower low JJR cord-014516-r59usk02 2127 21 hematocrit hematocrit NN cord-014516-r59usk02 2127 22 value value NN cord-014516-r59usk02 2127 23 . . . cord-014516-r59usk02 2128 1 Puppies puppy NNS cord-014516-r59usk02 2128 2 of of IN cord-014516-r59usk02 2128 3 certain certain JJ cord-014516-r59usk02 2128 4 breeds breed NNS cord-014516-r59usk02 2128 5 are be VBP cord-014516-r59usk02 2128 6 routinely routinely RB cord-014516-r59usk02 2128 7 screened screen VBN cord-014516-r59usk02 2128 8 for for IN cord-014516-r59usk02 2128 9 the the DT cord-014516-r59usk02 2128 10 presence presence NN cord-014516-r59usk02 2128 11 of of IN cord-014516-r59usk02 2128 12 congenital congenital JJ cord-014516-r59usk02 2128 13 porto porto JJ cord-014516-r59usk02 2128 14 - - HYPH cord-014516-r59usk02 2128 15 systemic systemic JJ cord-014516-r59usk02 2128 16 shunts shunt NNS cord-014516-r59usk02 2128 17 in in IN cord-014516-r59usk02 2128 18 the the DT cord-014516-r59usk02 2128 19 Netherlands Netherlands NNP cord-014516-r59usk02 2128 20 . . . cord-014516-r59usk02 2129 1 Breeders breeder NNS cord-014516-r59usk02 2129 2 bring bring VBP cord-014516-r59usk02 2129 3 their -PRON- PRP$ cord-014516-r59usk02 2129 4 nests nest NNS cord-014516-r59usk02 2129 5 to to IN cord-014516-r59usk02 2129 6 our -PRON- PRP$ cord-014516-r59usk02 2129 7 clinic clinic NN cord-014516-r59usk02 2129 8 for for IN cord-014516-r59usk02 2129 9 individual individual JJ cord-014516-r59usk02 2129 10 measurement measurement NN cord-014516-r59usk02 2129 11 of of IN cord-014516-r59usk02 2129 12 blood blood NN cord-014516-r59usk02 2129 13 ammonia ammonia NN cord-014516-r59usk02 2129 14 concentration concentration NN cord-014516-r59usk02 2129 15 . . . cord-014516-r59usk02 2130 1 In in IN cord-014516-r59usk02 2130 2 one one CD cord-014516-r59usk02 2130 3 year year NN cord-014516-r59usk02 2130 4 time time NN cord-014516-r59usk02 2130 5 ( ( -LRB- cord-014516-r59usk02 2130 6 from from IN cord-014516-r59usk02 2130 7 February February NNP cord-014516-r59usk02 2130 8 2013 2013 CD cord-014516-r59usk02 2130 9 until until IN cord-014516-r59usk02 2130 10 January January NNP cord-014516-r59usk02 2130 11 2014 2014 CD cord-014516-r59usk02 2130 12 ) ) -RRB- cord-014516-r59usk02 2131 1 389 389 CD cord-014516-r59usk02 2131 2 dogs dog NNS cord-014516-r59usk02 2131 3 of of IN cord-014516-r59usk02 2131 4 11 11 CD cord-014516-r59usk02 2131 5 different different JJ cord-014516-r59usk02 2131 6 breeds breed NNS cord-014516-r59usk02 2131 7 were be VBD cord-014516-r59usk02 2131 8 examined examine VBN cord-014516-r59usk02 2131 9 , , , cord-014516-r59usk02 2131 10 with with IN cord-014516-r59usk02 2131 11 295 295 CD cord-014516-r59usk02 2131 12 of of IN cord-014516-r59usk02 2131 13 them -PRON- PRP cord-014516-r59usk02 2131 14 being be VBG cord-014516-r59usk02 2131 15 cairn cairn NN cord-014516-r59usk02 2131 16 terriers terrier NNS cord-014516-r59usk02 2131 17 . . . cord-014516-r59usk02 2132 1 The the DT cord-014516-r59usk02 2132 2 age age NN cord-014516-r59usk02 2132 3 of of IN cord-014516-r59usk02 2132 4 the the DT cord-014516-r59usk02 2132 5 dogs dog NNS cord-014516-r59usk02 2132 6 varied vary VBN cord-014516-r59usk02 2132 7 from from IN cord-014516-r59usk02 2132 8 20 20 CD cord-014516-r59usk02 2132 9 to to TO cord-014516-r59usk02 2132 10 108 108 CD cord-014516-r59usk02 2132 11 days day NNS cord-014516-r59usk02 2132 12 ( ( -LRB- cord-014516-r59usk02 2132 13 mean mean VB cord-014516-r59usk02 2132 14 53 53 CD cord-014516-r59usk02 2132 15 days day NNS cord-014516-r59usk02 2132 16 ) ) -RRB- cord-014516-r59usk02 2132 17 . . . cord-014516-r59usk02 2133 1 While while IN cord-014516-r59usk02 2133 2 the the DT cord-014516-r59usk02 2133 3 breeders breeder NNS cord-014516-r59usk02 2133 4 were be VBD cord-014516-r59usk02 2133 5 waiting wait VBG cord-014516-r59usk02 2133 6 for for IN cord-014516-r59usk02 2133 7 the the DT cord-014516-r59usk02 2133 8 blood blood NN cord-014516-r59usk02 2133 9 results result NNS cord-014516-r59usk02 2133 10 , , , cord-014516-r59usk02 2133 11 the the DT cord-014516-r59usk02 2133 12 cardiac cardiac JJ cord-014516-r59usk02 2133 13 auscultation auscultation NN cord-014516-r59usk02 2133 14 was be VBD cord-014516-r59usk02 2133 15 performed perform VBN cord-014516-r59usk02 2133 16 by by IN cord-014516-r59usk02 2133 17 a a DT cord-014516-r59usk02 2133 18 single single JJ cord-014516-r59usk02 2133 19 board board NN cord-014516-r59usk02 2133 20 - - HYPH cord-014516-r59usk02 2133 21 certified certify VBN cord-014516-r59usk02 2133 22 cardiologist cardiologist NN cord-014516-r59usk02 2133 23 ( ( -LRB- cord-014516-r59usk02 2133 24 VSz VSz NNP cord-014516-r59usk02 2133 25 ) ) -RRB- cord-014516-r59usk02 2133 26 . . . cord-014516-r59usk02 2134 1 Hematocrit hematocrit NN cord-014516-r59usk02 2134 2 was be VBD cord-014516-r59usk02 2134 3 measured measure VBN cord-014516-r59usk02 2134 4 with with IN cord-014516-r59usk02 2134 5 an an DT cord-014516-r59usk02 2134 6 automatized automatized JJ cord-014516-r59usk02 2134 7 hematology hematology NN cord-014516-r59usk02 2134 8 analyzer analyzer NN cord-014516-r59usk02 2134 9 system system NN cord-014516-r59usk02 2134 10 from from IN cord-014516-r59usk02 2134 11 the the DT cord-014516-r59usk02 2134 12 surplus surplus NN cord-014516-r59usk02 2134 13 blood blood NN cord-014516-r59usk02 2134 14 sample sample NN cord-014516-r59usk02 2134 15 . . . cord-014516-r59usk02 2135 1 Cardiac cardiac JJ cord-014516-r59usk02 2135 2 murmur murmur NN cord-014516-r59usk02 2135 3 was be VBD cord-014516-r59usk02 2135 4 found find VBN cord-014516-r59usk02 2135 5 in in IN cord-014516-r59usk02 2135 6 59 59 CD cord-014516-r59usk02 2135 7 dogs dog NNS cord-014516-r59usk02 2135 8 ( ( -LRB- cord-014516-r59usk02 2135 9 15 15 CD cord-014516-r59usk02 2135 10 % % NN cord-014516-r59usk02 2135 11 ) ) -RRB- cord-014516-r59usk02 2135 12 . . . cord-014516-r59usk02 2136 1 In in IN cord-014516-r59usk02 2136 2 all all DT cord-014516-r59usk02 2136 3 cases case NNS cord-014516-r59usk02 2136 4 this this DT cord-014516-r59usk02 2136 5 was be VBD cord-014516-r59usk02 2136 6 a a DT cord-014516-r59usk02 2136 7 soft soft JJ cord-014516-r59usk02 2136 8 ( ( -LRB- cord-014516-r59usk02 2136 9 1 1 CD cord-014516-r59usk02 2136 10 - - SYM cord-014516-r59usk02 2136 11 2 2 CD cord-014516-r59usk02 2136 12 out out IN cord-014516-r59usk02 2136 13 of of IN cord-014516-r59usk02 2136 14 6 6 CD cord-014516-r59usk02 2136 15 ) ) -RRB- cord-014516-r59usk02 2136 16 systolic systolic JJ cord-014516-r59usk02 2136 17 murmur murmur NN cord-014516-r59usk02 2136 18 , , , cord-014516-r59usk02 2136 19 most most JJS cord-014516-r59usk02 2136 20 of of IN cord-014516-r59usk02 2136 21 the the DT cord-014516-r59usk02 2136 22 time time NN cord-014516-r59usk02 2136 23 with with IN cord-014516-r59usk02 2136 24 a a DT cord-014516-r59usk02 2136 25 musical musical JJ cord-014516-r59usk02 2136 26 character character NN cord-014516-r59usk02 2136 27 and and CC cord-014516-r59usk02 2136 28 with with IN cord-014516-r59usk02 2136 29 the the DT cord-014516-r59usk02 2136 30 point point NN cord-014516-r59usk02 2136 31 of of IN cord-014516-r59usk02 2136 32 maximal maximal JJ cord-014516-r59usk02 2136 33 intensity intensity NN cord-014516-r59usk02 2136 34 on on IN cord-014516-r59usk02 2136 35 the the DT cord-014516-r59usk02 2136 36 left left JJ cord-014516-r59usk02 2136 37 hemithorax hemithorax NN cord-014516-r59usk02 2136 38 , , , cord-014516-r59usk02 2136 39 compatible compatible JJ cord-014516-r59usk02 2136 40 with with IN cord-014516-r59usk02 2136 41 the the DT cord-014516-r59usk02 2136 42 description description NN cord-014516-r59usk02 2136 43 of of IN cord-014516-r59usk02 2136 44 an an DT cord-014516-r59usk02 2136 45 innocent innocent JJ cord-014516-r59usk02 2136 46 cardiac cardiac JJ cord-014516-r59usk02 2136 47 murmur murmur NN cord-014516-r59usk02 2136 48 . . . cord-014516-r59usk02 2137 1 No no DT cord-014516-r59usk02 2137 2 murmurs murmur NNS cord-014516-r59usk02 2137 3 were be VBD cord-014516-r59usk02 2137 4 found find VBN cord-014516-r59usk02 2137 5 that that WDT cord-014516-r59usk02 2137 6 could could MD cord-014516-r59usk02 2137 7 be be VB cord-014516-r59usk02 2137 8 compatible compatible JJ cord-014516-r59usk02 2137 9 with with IN cord-014516-r59usk02 2137 10 a a DT cord-014516-r59usk02 2137 11 congenital congenital JJ cord-014516-r59usk02 2137 12 cardiac cardiac JJ cord-014516-r59usk02 2137 13 anomaly anomaly NN cord-014516-r59usk02 2137 14 . . . cord-014516-r59usk02 2138 1 The the DT cord-014516-r59usk02 2138 2 hematocrit hematocrit NN cord-014516-r59usk02 2138 3 was be VBD cord-014516-r59usk02 2138 4 significantly significantly RB cord-014516-r59usk02 2138 5 ( ( -LRB- cord-014516-r59usk02 2138 6 P p NN cord-014516-r59usk02 2138 7 = = SYM cord-014516-r59usk02 2138 8 0.003 0.003 CD cord-014516-r59usk02 2138 9 ) ) -RRB- cord-014516-r59usk02 2138 10 lower low JJR cord-014516-r59usk02 2138 11 in in IN cord-014516-r59usk02 2138 12 the the DT cord-014516-r59usk02 2138 13 group group NN cord-014516-r59usk02 2138 14 of of IN cord-014516-r59usk02 2138 15 dogs dog NNS cord-014516-r59usk02 2138 16 with with IN cord-014516-r59usk02 2138 17 a a DT cord-014516-r59usk02 2138 18 murmur murmur NN cord-014516-r59usk02 2138 19 ( ( -LRB- cord-014516-r59usk02 2139 1 mean mean VB cord-014516-r59usk02 2139 2 30.9 30.9 CD cord-014516-r59usk02 2139 3 % % NN cord-014516-r59usk02 2139 4 , , , cord-014516-r59usk02 2139 5 standard standard JJ cord-014516-r59usk02 2139 6 deviation deviation NN cord-014516-r59usk02 2139 7 2.8 2.8 CD cord-014516-r59usk02 2139 8 % % NN cord-014516-r59usk02 2139 9 ) ) -RRB- cord-014516-r59usk02 2139 10 compared compare VBN cord-014516-r59usk02 2139 11 to to IN cord-014516-r59usk02 2139 12 the the DT cord-014516-r59usk02 2139 13 group group NN cord-014516-r59usk02 2139 14 without without IN cord-014516-r59usk02 2139 15 a a DT cord-014516-r59usk02 2139 16 murmur murmur NN cord-014516-r59usk02 2139 17 ( ( -LRB- cord-014516-r59usk02 2139 18 mean mean VB cord-014516-r59usk02 2139 19 32.2 32.2 CD cord-014516-r59usk02 2139 20 % % NN cord-014516-r59usk02 2139 21 , , , cord-014516-r59usk02 2139 22 standard standard JJ cord-014516-r59usk02 2139 23 deviation deviation NN cord-014516-r59usk02 2139 24 3.1 3.1 CD cord-014516-r59usk02 2139 25 % % NN cord-014516-r59usk02 2139 26 ) ) -RRB- cord-014516-r59usk02 2139 27 . . . cord-014516-r59usk02 2140 1 Multivariate multivariate JJ cord-014516-r59usk02 2140 2 analysis analysis NN cord-014516-r59usk02 2140 3 shows show VBZ cord-014516-r59usk02 2140 4 that that IN cord-014516-r59usk02 2140 5 the the DT cord-014516-r59usk02 2140 6 presence presence NN cord-014516-r59usk02 2140 7 of of IN cord-014516-r59usk02 2140 8 murmur murmur NN cord-014516-r59usk02 2140 9 is be VBZ cord-014516-r59usk02 2140 10 correlated correlate VBN cord-014516-r59usk02 2140 11 with with IN cord-014516-r59usk02 2140 12 the the DT cord-014516-r59usk02 2140 13 hematocrit hematocrit NN cord-014516-r59usk02 2140 14 , , , cord-014516-r59usk02 2140 15 but but CC cord-014516-r59usk02 2140 16 not not RB cord-014516-r59usk02 2140 17 with with IN cord-014516-r59usk02 2140 18 the the DT cord-014516-r59usk02 2140 19 age age NN cord-014516-r59usk02 2140 20 of of IN cord-014516-r59usk02 2140 21 the the DT cord-014516-r59usk02 2140 22 dogs dog NNS cord-014516-r59usk02 2140 23 . . . cord-014516-r59usk02 2141 1 Physiologic physiologic JJ cord-014516-r59usk02 2141 2 anemia anemia NN cord-014516-r59usk02 2141 3 has have VBZ cord-014516-r59usk02 2141 4 been be VBN cord-014516-r59usk02 2141 5 long long RB cord-014516-r59usk02 2141 6 suspected suspect VBN cord-014516-r59usk02 2141 7 to to TO cord-014516-r59usk02 2141 8 be be VB cord-014516-r59usk02 2141 9 one one CD cord-014516-r59usk02 2141 10 of of IN cord-014516-r59usk02 2141 11 the the DT cord-014516-r59usk02 2141 12 possible possible JJ cord-014516-r59usk02 2141 13 causes cause NNS cord-014516-r59usk02 2141 14 of of IN cord-014516-r59usk02 2141 15 innocent innocent JJ cord-014516-r59usk02 2141 16 cardiac cardiac JJ cord-014516-r59usk02 2141 17 murmurs murmur NNS cord-014516-r59usk02 2141 18 in in IN cord-014516-r59usk02 2141 19 young young JJ cord-014516-r59usk02 2141 20 animals animal NNS cord-014516-r59usk02 2141 21 and and CC cord-014516-r59usk02 2141 22 children child NNS cord-014516-r59usk02 2141 23 . . . cord-014516-r59usk02 2142 1 However however RB cord-014516-r59usk02 2142 2 , , , cord-014516-r59usk02 2142 3 according accord VBG cord-014516-r59usk02 2142 4 to to IN cord-014516-r59usk02 2142 5 the the DT cord-014516-r59usk02 2142 6 authors author NNS cord-014516-r59usk02 2142 7 knowledge knowledge NN cord-014516-r59usk02 2142 8 , , , cord-014516-r59usk02 2142 9 no no DT cord-014516-r59usk02 2142 10 published publish VBN cord-014516-r59usk02 2142 11 reports report NNS cord-014516-r59usk02 2142 12 exist exist VBP cord-014516-r59usk02 2142 13 that that WDT cord-014516-r59usk02 2142 14 looked look VBD cord-014516-r59usk02 2142 15 for for IN cord-014516-r59usk02 2142 16 a a DT cord-014516-r59usk02 2142 17 possible possible JJ cord-014516-r59usk02 2142 18 correlation correlation NN cord-014516-r59usk02 2142 19 . . . cord-014516-r59usk02 2143 1 Which which WDT cord-014516-r59usk02 2143 2 other other JJ cord-014516-r59usk02 2143 3 factors factor NNS cord-014516-r59usk02 2143 4 contribute contribute VBP cord-014516-r59usk02 2143 5 to to IN cord-014516-r59usk02 2143 6 the the DT cord-014516-r59usk02 2143 7 presence presence NN cord-014516-r59usk02 2143 8 of of IN cord-014516-r59usk02 2143 9 an an DT cord-014516-r59usk02 2143 10 innocent innocent JJ cord-014516-r59usk02 2143 11 murmur murmur NN cord-014516-r59usk02 2143 12 is be VBZ cord-014516-r59usk02 2143 13 largely largely RB cord-014516-r59usk02 2143 14 unknown unknown JJ cord-014516-r59usk02 2143 15 . . . cord-014516-r59usk02 2144 1 Because because IN cord-014516-r59usk02 2144 2 of of IN cord-014516-r59usk02 2144 3 a a DT cord-014516-r59usk02 2144 4 large large JJ cord-014516-r59usk02 2144 5 overlap overlap NN cord-014516-r59usk02 2144 6 between between IN cord-014516-r59usk02 2144 7 the the DT cord-014516-r59usk02 2144 8 hematocrit hematocrit NN cord-014516-r59usk02 2144 9 values value NNS cord-014516-r59usk02 2144 10 of of IN cord-014516-r59usk02 2144 11 dogs dog NNS cord-014516-r59usk02 2144 12 with with IN cord-014516-r59usk02 2144 13 and and CC cord-014516-r59usk02 2144 14 without without IN cord-014516-r59usk02 2144 15 a a DT cord-014516-r59usk02 2144 16 cardiac cardiac JJ cord-014516-r59usk02 2144 17 murmur murmur NN cord-014516-r59usk02 2144 18 , , , cord-014516-r59usk02 2144 19 measuring measure VBG cord-014516-r59usk02 2144 20 hematocrit hematocrit NN cord-014516-r59usk02 2144 21 in in IN cord-014516-r59usk02 2144 22 a a DT cord-014516-r59usk02 2144 23 particular particular JJ cord-014516-r59usk02 2144 24 pup pup NN cord-014516-r59usk02 2144 25 would would MD cord-014516-r59usk02 2144 26 not not RB cord-014516-r59usk02 2144 27 help help VB cord-014516-r59usk02 2144 28 a a DT cord-014516-r59usk02 2144 29 less less RBR cord-014516-r59usk02 2144 30 experienced experienced JJ cord-014516-r59usk02 2144 31 first first JJ cord-014516-r59usk02 2144 32 line line NN cord-014516-r59usk02 2144 33 veterinary veterinary JJ cord-014516-r59usk02 2144 34 practitioner practitioner NN cord-014516-r59usk02 2144 35 to to TO cord-014516-r59usk02 2144 36 decide decide VB cord-014516-r59usk02 2144 37 whether whether IN cord-014516-r59usk02 2144 38 a a DT cord-014516-r59usk02 2144 39 murmur murmur NN cord-014516-r59usk02 2144 40 is be VBZ cord-014516-r59usk02 2144 41 innocent innocent JJ cord-014516-r59usk02 2144 42 or or CC cord-014516-r59usk02 2144 43 the the DT cord-014516-r59usk02 2144 44 result result NN cord-014516-r59usk02 2144 45 of of IN cord-014516-r59usk02 2144 46 a a DT cord-014516-r59usk02 2144 47 congenital congenital JJ cord-014516-r59usk02 2144 48 cardiac cardiac JJ cord-014516-r59usk02 2144 49 anomaly anomaly NN cord-014516-r59usk02 2144 50 . . . cord-014516-r59usk02 2145 1 Limitation limitation NN cord-014516-r59usk02 2145 2 of of IN cord-014516-r59usk02 2145 3 this this DT cord-014516-r59usk02 2145 4 study study NN cord-014516-r59usk02 2145 5 is be VBZ cord-014516-r59usk02 2145 6 that that IN cord-014516-r59usk02 2145 7 no no DT cord-014516-r59usk02 2145 8 echocardiography echocardiography NN cord-014516-r59usk02 2145 9 was be VBD cord-014516-r59usk02 2145 10 performed perform VBN cord-014516-r59usk02 2145 11 to to TO cord-014516-r59usk02 2145 12 rule rule VB cord-014516-r59usk02 2145 13 out out RP cord-014516-r59usk02 2145 14 congenital congenital JJ cord-014516-r59usk02 2145 15 cardiac cardiac JJ cord-014516-r59usk02 2145 16 anomalies anomaly NNS cord-014516-r59usk02 2145 17 as as IN cord-014516-r59usk02 2145 18 the the DT cord-014516-r59usk02 2145 19 cause cause NN cord-014516-r59usk02 2145 20 of of IN cord-014516-r59usk02 2145 21 the the DT cord-014516-r59usk02 2145 22 murmurs murmur NNS cord-014516-r59usk02 2145 23 . . . cord-014516-r59usk02 2146 1 Neither neither DT cord-014516-r59usk02 2146 2 were be VBD cord-014516-r59usk02 2146 3 the the DT cord-014516-r59usk02 2146 4 dogs dog NNS cord-014516-r59usk02 2146 5 re re VB cord-014516-r59usk02 2146 6 - - VBD cord-014516-r59usk02 2146 7 checked check VBN cord-014516-r59usk02 2146 8 for for IN cord-014516-r59usk02 2146 9 spontaneously spontaneously RB cord-014516-r59usk02 2146 10 disappearance disappearance NN cord-014516-r59usk02 2146 11 of of IN cord-014516-r59usk02 2146 12 the the DT cord-014516-r59usk02 2146 13 murmur murmur NN cord-014516-r59usk02 2146 14 . . . cord-014516-r59usk02 2147 1 No no DT cord-014516-r59usk02 2147 2 conflicts conflict NNS cord-014516-r59usk02 2147 3 of of IN cord-014516-r59usk02 2147 4 interest interest NN cord-014516-r59usk02 2147 5 reported report VBN cord-014516-r59usk02 2147 6 . . . cord-014516-r59usk02 2148 1 Low low JJ cord-014516-r59usk02 2148 2 intensity intensity NN cord-014516-r59usk02 2148 3 systolic systolic JJ cord-014516-r59usk02 2148 4 murmurs murmur NNS cord-014516-r59usk02 2148 5 , , , cord-014516-r59usk02 2148 6 with with IN cord-014516-r59usk02 2148 7 point point NN cord-014516-r59usk02 2148 8 of of IN cord-014516-r59usk02 2148 9 maximal maximal JJ cord-014516-r59usk02 2148 10 intensity intensity NN cord-014516-r59usk02 2148 11 over over IN cord-014516-r59usk02 2148 12 the the DT cord-014516-r59usk02 2148 13 outflow outflow JJ cord-014516-r59usk02 2148 14 tract tract NN cord-014516-r59usk02 2148 15 on on IN cord-014516-r59usk02 2148 16 the the DT cord-014516-r59usk02 2148 17 left left JJ cord-014516-r59usk02 2148 18 side side NN cord-014516-r59usk02 2148 19 of of IN cord-014516-r59usk02 2148 20 thorax thorax NN cord-014516-r59usk02 2148 21 , , , cord-014516-r59usk02 2148 22 are be VBP cord-014516-r59usk02 2148 23 not not RB cord-014516-r59usk02 2148 24 uncommonly uncommonly RB cord-014516-r59usk02 2148 25 heard hear VBN cord-014516-r59usk02 2148 26 during during IN cord-014516-r59usk02 2148 27 cardiac cardiac JJ cord-014516-r59usk02 2148 28 auscultation auscultation NN cord-014516-r59usk02 2148 29 of of IN cord-014516-r59usk02 2148 30 apparently apparently RB cord-014516-r59usk02 2148 31 healthy healthy JJ cord-014516-r59usk02 2148 32 Siberian siberian JJ cord-014516-r59usk02 2148 33 husky husky JJ cord-014516-r59usk02 2148 34 dogs dog NNS cord-014516-r59usk02 2148 35 , , , cord-014516-r59usk02 2148 36 often often RB cord-014516-r59usk02 2148 37 with with IN cord-014516-r59usk02 2148 38 excellent excellent JJ cord-014516-r59usk02 2148 39 exercise exercise NN cord-014516-r59usk02 2148 40 tolerance tolerance NN cord-014516-r59usk02 2148 41 . . . cord-014516-r59usk02 2149 1 The the DT cord-014516-r59usk02 2149 2 origin origin NN cord-014516-r59usk02 2149 3 of of IN cord-014516-r59usk02 2149 4 these these DT cord-014516-r59usk02 2149 5 murmurs murmur NNS cord-014516-r59usk02 2149 6 in in IN cord-014516-r59usk02 2149 7 athletic athletic JJ cord-014516-r59usk02 2149 8 dogs dog NNS cord-014516-r59usk02 2149 9 such such JJ cord-014516-r59usk02 2149 10 as as IN cord-014516-r59usk02 2149 11 huskies husky NNS cord-014516-r59usk02 2149 12 is be VBZ cord-014516-r59usk02 2149 13 unlikely unlikely JJ cord-014516-r59usk02 2149 14 to to TO cord-014516-r59usk02 2149 15 be be VB cord-014516-r59usk02 2149 16 due due JJ cord-014516-r59usk02 2149 17 to to IN cord-014516-r59usk02 2149 18 heart heart NN cord-014516-r59usk02 2149 19 disease disease NN cord-014516-r59usk02 2149 20 but but CC cord-014516-r59usk02 2149 21 more more RBR cord-014516-r59usk02 2149 22 likely likely JJ cord-014516-r59usk02 2149 23 due due JJ cord-014516-r59usk02 2149 24 to to IN cord-014516-r59usk02 2149 25 turbulent turbulent JJ cord-014516-r59usk02 2149 26 blood blood NN cord-014516-r59usk02 2149 27 flow flow NN cord-014516-r59usk02 2149 28 in in IN cord-014516-r59usk02 2149 29 the the DT cord-014516-r59usk02 2149 30 outflow outflow JJ cord-014516-r59usk02 2149 31 tract tract NN cord-014516-r59usk02 2149 32 caused cause VBN cord-014516-r59usk02 2149 33 by by IN cord-014516-r59usk02 2149 34 a a DT cord-014516-r59usk02 2149 35 large large JJ cord-014516-r59usk02 2149 36 stroke stroke NN cord-014516-r59usk02 2149 37 volume volume NN cord-014516-r59usk02 2149 38 and and CC cord-014516-r59usk02 2149 39 forceful forceful JJ cord-014516-r59usk02 2149 40 cardiac cardiac JJ cord-014516-r59usk02 2149 41 contractility contractility NN cord-014516-r59usk02 2149 42 in in IN cord-014516-r59usk02 2149 43 early early JJ cord-014516-r59usk02 2149 44 systole systole NN cord-014516-r59usk02 2149 45 . . . cord-014516-r59usk02 2150 1 The the DT cord-014516-r59usk02 2150 2 differentiation differentiation NN cord-014516-r59usk02 2150 3 of of IN cord-014516-r59usk02 2150 4 these these DT cord-014516-r59usk02 2150 5 murmurs murmur NNS cord-014516-r59usk02 2150 6 from from IN cord-014516-r59usk02 2150 7 " " `` cord-014516-r59usk02 2150 8 pathological"significant pathological"significant . cord-014516-r59usk02 2150 9 murmurs murmur NNS cord-014516-r59usk02 2150 10 can can MD cord-014516-r59usk02 2150 11 however however RB cord-014516-r59usk02 2150 12 be be VB cord-014516-r59usk02 2150 13 problematic problematic JJ cord-014516-r59usk02 2150 14 in in IN cord-014516-r59usk02 2150 15 general general JJ cord-014516-r59usk02 2150 16 practice practice NN cord-014516-r59usk02 2150 17 . . . cord-014516-r59usk02 2151 1 The the DT cord-014516-r59usk02 2151 2 aim aim NN cord-014516-r59usk02 2151 3 of of IN cord-014516-r59usk02 2151 4 the the DT cord-014516-r59usk02 2151 5 present present JJ cord-014516-r59usk02 2151 6 study study NN cord-014516-r59usk02 2151 7 was be VBD cord-014516-r59usk02 2151 8 to to TO cord-014516-r59usk02 2151 9 investigate investigate VB cord-014516-r59usk02 2151 10 the the DT cord-014516-r59usk02 2151 11 prevalence prevalence NN cord-014516-r59usk02 2151 12 of of IN cord-014516-r59usk02 2151 13 murmurs murmur NNS cord-014516-r59usk02 2151 14 in in IN cord-014516-r59usk02 2151 15 a a DT cord-014516-r59usk02 2151 16 sample sample NN cord-014516-r59usk02 2151 17 of of IN cord-014516-r59usk02 2151 18 successfully successfully RB cord-014516-r59usk02 2151 19 racing race VBG cord-014516-r59usk02 2151 20 Siberian siberian JJ cord-014516-r59usk02 2151 21 husky husky JJ cord-014516-r59usk02 2151 22 dogs dog NNS cord-014516-r59usk02 2151 23 and and CC cord-014516-r59usk02 2151 24 furthermore furthermore RB cord-014516-r59usk02 2151 25 to to TO cord-014516-r59usk02 2151 26 study study VB cord-014516-r59usk02 2151 27 the the DT cord-014516-r59usk02 2151 28 phonocardiographic phonocardiographic JJ cord-014516-r59usk02 2151 29 characteristics characteristic NNS cord-014516-r59usk02 2151 30 of of IN cord-014516-r59usk02 2151 31 these these DT cord-014516-r59usk02 2151 32 murmurs murmur NNS cord-014516-r59usk02 2151 33 . . . cord-014516-r59usk02 2152 1 Phonocardiograms Phonocardiograms NNP cord-014516-r59usk02 2152 2 and and CC cord-014516-r59usk02 2152 3 ECGs ecg NNS cord-014516-r59usk02 2152 4 were be VBD cord-014516-r59usk02 2152 5 recorded record VBN cord-014516-r59usk02 2152 6 in in IN cord-014516-r59usk02 2152 7 37 37 CD cord-014516-r59usk02 2152 8 actively actively RB cord-014516-r59usk02 2152 9 racing race VBG cord-014516-r59usk02 2152 10 Siberian siberian JJ cord-014516-r59usk02 2152 11 husky husky JJ cord-014516-r59usk02 2152 12 dogs dog NNS cord-014516-r59usk02 2152 13 , , , cord-014516-r59usk02 2152 14 with with IN cord-014516-r59usk02 2152 15 normal normal JJ cord-014516-r59usk02 2152 16 or or CC cord-014516-r59usk02 2152 17 excellent excellent JJ cord-014516-r59usk02 2152 18 exercise exercise NN cord-014516-r59usk02 2152 19 tolerance tolerance NN cord-014516-r59usk02 2152 20 . . . cord-014516-r59usk02 2153 1 Normal normal JJ cord-014516-r59usk02 2153 2 stamina stamina NN cord-014516-r59usk02 2153 3 was be VBD cord-014516-r59usk02 2153 4 confirmed confirm VBN cord-014516-r59usk02 2153 5 by by IN cord-014516-r59usk02 2153 6 successful successful JJ cord-014516-r59usk02 2153 7 racing racing NN cord-014516-r59usk02 2153 8 . . . cord-014516-r59usk02 2154 1 Phonocardiograms Phonocardiograms NNP cord-014516-r59usk02 2154 2 were be VBD cord-014516-r59usk02 2154 3 easy easy JJ cord-014516-r59usk02 2154 4 and and CC cord-014516-r59usk02 2154 5 rapid rapid JJ cord-014516-r59usk02 2154 6 to to TO cord-014516-r59usk02 2154 7 record record VB cord-014516-r59usk02 2154 8 on on IN cord-014516-r59usk02 2154 9 a a DT cord-014516-r59usk02 2154 10 PC pc NN cord-014516-r59usk02 2154 11 laptop laptop NN cord-014516-r59usk02 2154 12 connected connect VBN cord-014516-r59usk02 2154 13 to to IN cord-014516-r59usk02 2154 14 the the DT cord-014516-r59usk02 2154 15 Meditron Meditron NNP cord-014516-r59usk02 2154 16 stethoscope stethoscope NN cord-014516-r59usk02 2154 17 in in IN cord-014516-r59usk02 2154 18 ambulant ambulant JJ cord-014516-r59usk02 2154 19 " " '' cord-014516-r59usk02 2154 20 field"practice field"practice FW cord-014516-r59usk02 2154 21 . . . cord-014516-r59usk02 2155 1 Systole Systole NNP cord-014516-r59usk02 2155 2 was be VBD cord-014516-r59usk02 2155 3 measured measure VBN cord-014516-r59usk02 2155 4 as as IN cord-014516-r59usk02 2155 5 the the DT cord-014516-r59usk02 2155 6 duration duration NN cord-014516-r59usk02 2155 7 measured measure VBN cord-014516-r59usk02 2155 8 from from IN cord-014516-r59usk02 2155 9 the the DT cord-014516-r59usk02 2155 10 onset onset NN cord-014516-r59usk02 2155 11 of of IN cord-014516-r59usk02 2155 12 the the DT cord-014516-r59usk02 2155 13 first first JJ cord-014516-r59usk02 2155 14 heart heart NN cord-014516-r59usk02 2155 15 sound sound VB cord-014516-r59usk02 2155 16 to to IN cord-014516-r59usk02 2155 17 the the DT cord-014516-r59usk02 2155 18 onset onset NN cord-014516-r59usk02 2155 19 of of IN cord-014516-r59usk02 2155 20 the the DT cord-014516-r59usk02 2155 21 second second JJ cord-014516-r59usk02 2155 22 heart heart NN cord-014516-r59usk02 2155 23 sound sound NN cord-014516-r59usk02 2155 24 and and CC cord-014516-r59usk02 2155 25 the the DT cord-014516-r59usk02 2155 26 murmur murmur NN cord-014516-r59usk02 2155 27 duration duration NN cord-014516-r59usk02 2155 28 from from IN cord-014516-r59usk02 2155 29 the the DT cord-014516-r59usk02 2155 30 onset onset NN cord-014516-r59usk02 2155 31 the the DT cord-014516-r59usk02 2155 32 first first JJ cord-014516-r59usk02 2155 33 heart heart NN cord-014516-r59usk02 2155 34 sound sound VB cord-014516-r59usk02 2155 35 to to IN cord-014516-r59usk02 2155 36 the the DT cord-014516-r59usk02 2155 37 end end NN cord-014516-r59usk02 2155 38 of of IN cord-014516-r59usk02 2155 39 the the DT cord-014516-r59usk02 2155 40 murmur murmur NN cord-014516-r59usk02 2155 41 . . . cord-014516-r59usk02 2156 1 The the DT cord-014516-r59usk02 2156 2 duration duration NN cord-014516-r59usk02 2156 3 of of IN cord-014516-r59usk02 2156 4 the the DT cord-014516-r59usk02 2156 5 first first JJ cord-014516-r59usk02 2156 6 heart heart NN cord-014516-r59usk02 2156 7 sound sound NN cord-014516-r59usk02 2156 8 plus plus CC cord-014516-r59usk02 2156 9 the the DT cord-014516-r59usk02 2156 10 murmur murmur NN cord-014516-r59usk02 2156 11 was be VBD cord-014516-r59usk02 2156 12 measured measure VBN cord-014516-r59usk02 2156 13 and and CC cord-014516-r59usk02 2156 14 calculated calculate VBN cord-014516-r59usk02 2156 15 as as IN cord-014516-r59usk02 2156 16 a a DT cord-014516-r59usk02 2156 17 percentage percentage NN cord-014516-r59usk02 2156 18 of of IN cord-014516-r59usk02 2156 19 the the DT cord-014516-r59usk02 2156 20 duration duration NN cord-014516-r59usk02 2156 21 of of IN cord-014516-r59usk02 2156 22 systole systole NN cord-014516-r59usk02 2156 23 . . . cord-014516-r59usk02 2157 1 Cardiac cardiac JJ cord-014516-r59usk02 2157 2 murmurs murmur NNS cord-014516-r59usk02 2157 3 of of IN cord-014516-r59usk02 2157 4 grade grade NN cord-014516-r59usk02 2157 5 1 1 CD cord-014516-r59usk02 2157 6 - - SYM cord-014516-r59usk02 2157 7 2 2 CD cord-014516-r59usk02 2157 8 were be VBD cord-014516-r59usk02 2157 9 heard hear VBN cord-014516-r59usk02 2157 10 in in IN cord-014516-r59usk02 2157 11 22 22 CD cord-014516-r59usk02 2157 12 % % NN cord-014516-r59usk02 2157 13 of of IN cord-014516-r59usk02 2157 14 dogs dog NNS cord-014516-r59usk02 2157 15 examined examine VBN cord-014516-r59usk02 2157 16 . . . cord-014516-r59usk02 2158 1 Phonocardiogram Phonocardiogram NNP cord-014516-r59usk02 2158 2 from from IN cord-014516-r59usk02 2158 3 these these DT cord-014516-r59usk02 2158 4 dogs dog NNS cord-014516-r59usk02 2158 5 revealed reveal VBD cord-014516-r59usk02 2158 6 early early JJ cord-014516-r59usk02 2158 7 systolic systolic JJ cord-014516-r59usk02 2158 8 crescendo crescendo NN cord-014516-r59usk02 2158 9 - - HYPH cord-014516-r59usk02 2158 10 decrescendo decrescendo NN cord-014516-r59usk02 2158 11 or or CC cord-014516-r59usk02 2158 12 decrescendo decrescendo NN cord-014516-r59usk02 2158 13 murmurs murmur NNS cord-014516-r59usk02 2158 14 with with IN cord-014516-r59usk02 2158 15 a a DT cord-014516-r59usk02 2158 16 duration duration NN cord-014516-r59usk02 2158 17 of of IN cord-014516-r59usk02 2158 18 maximally maximally RB cord-014516-r59usk02 2158 19 75 75 CD cord-014516-r59usk02 2158 20 % % NN cord-014516-r59usk02 2158 21 into into IN cord-014516-r59usk02 2158 22 systole systole NN cord-014516-r59usk02 2158 23 . . . cord-014516-r59usk02 2159 1 All all DT cord-014516-r59usk02 2159 2 dogs dog NNS cord-014516-r59usk02 2159 3 with with IN cord-014516-r59usk02 2159 4 murmurs murmur NNS cord-014516-r59usk02 2159 5 had have VBD cord-014516-r59usk02 2159 6 a a DT cord-014516-r59usk02 2159 7 silent silent JJ cord-014516-r59usk02 2159 8 pause pause NN cord-014516-r59usk02 2159 9 at at IN cord-014516-r59usk02 2159 10 the the DT cord-014516-r59usk02 2159 11 end end NN cord-014516-r59usk02 2159 12 of of IN cord-014516-r59usk02 2159 13 systole systole NN cord-014516-r59usk02 2159 14 . . . cord-014516-r59usk02 2160 1 ECG ECG NNP cord-014516-r59usk02 2160 2 was be VBD cord-014516-r59usk02 2160 3 normal normal JJ cord-014516-r59usk02 2160 4 in in IN cord-014516-r59usk02 2160 5 all all DT cord-014516-r59usk02 2160 6 dogs dog NNS cord-014516-r59usk02 2160 7 . . . cord-014516-r59usk02 2161 1 Murmurs murmur NNS cord-014516-r59usk02 2161 2 in in IN cord-014516-r59usk02 2161 3 adult adult JJ cord-014516-r59usk02 2161 4 athletic athletic JJ cord-014516-r59usk02 2161 5 dogs dog NNS cord-014516-r59usk02 2161 6 should should MD cord-014516-r59usk02 2161 7 not not RB cord-014516-r59usk02 2161 8 be be VB cord-014516-r59usk02 2161 9 regarded regard VBN cord-014516-r59usk02 2161 10 as as IN cord-014516-r59usk02 2161 11 a a DT cord-014516-r59usk02 2161 12 definite definite JJ cord-014516-r59usk02 2161 13 sign sign NN cord-014516-r59usk02 2161 14 of of IN cord-014516-r59usk02 2161 15 heart heart NN cord-014516-r59usk02 2161 16 disease disease NN cord-014516-r59usk02 2161 17 . . . cord-014516-r59usk02 2162 1 Physiological physiological JJ cord-014516-r59usk02 2162 2 flow flow NN cord-014516-r59usk02 2162 3 murmurs murmur NNS cord-014516-r59usk02 2162 4 of of IN cord-014516-r59usk02 2162 5 up up IN cord-014516-r59usk02 2162 6 to to TO cord-014516-r59usk02 2162 7 75 75 CD cord-014516-r59usk02 2162 8 % % NN cord-014516-r59usk02 2162 9 of of IN cord-014516-r59usk02 2162 10 systole systole NN cord-014516-r59usk02 2162 11 is be VBZ cord-014516-r59usk02 2162 12 a a DT cord-014516-r59usk02 2162 13 common common JJ cord-014516-r59usk02 2162 14 finding finding NN cord-014516-r59usk02 2162 15 in in IN cord-014516-r59usk02 2162 16 active active JJ cord-014516-r59usk02 2162 17 Siberian siberian JJ cord-014516-r59usk02 2162 18 husky husky JJ cord-014516-r59usk02 2162 19 dogs dog NNS cord-014516-r59usk02 2162 20 ( ( -LRB- cord-014516-r59usk02 2162 21 prevalence prevalence NN cord-014516-r59usk02 2162 22 22 22 CD cord-014516-r59usk02 2162 23 % % NN cord-014516-r59usk02 2162 24 in in IN cord-014516-r59usk02 2162 25 the the DT cord-014516-r59usk02 2162 26 examined examine VBN cord-014516-r59usk02 2162 27 sample sample NN cord-014516-r59usk02 2162 28 ) ) -RRB- cord-014516-r59usk02 2162 29 . . . cord-014516-r59usk02 2163 1 Phonocardiography Phonocardiography NNP cord-014516-r59usk02 2163 2 is be VBZ cord-014516-r59usk02 2163 3 a a DT cord-014516-r59usk02 2163 4 rapid rapid JJ cord-014516-r59usk02 2163 5 and and CC cord-014516-r59usk02 2163 6 practical practical JJ cord-014516-r59usk02 2163 7 method method NN cord-014516-r59usk02 2163 8 for for IN cord-014516-r59usk02 2163 9 differential differential JJ cord-014516-r59usk02 2163 10 diagnoses diagnosis NNS cord-014516-r59usk02 2163 11 between between IN cord-014516-r59usk02 2163 12 pathological pathological JJ cord-014516-r59usk02 2163 13 murmurs murmur NNS cord-014516-r59usk02 2163 14 and and CC cord-014516-r59usk02 2163 15 physiological physiological JJ cord-014516-r59usk02 2163 16 flow flow NN cord-014516-r59usk02 2163 17 murmurs murmur NNS cord-014516-r59usk02 2163 18 . . . cord-014516-r59usk02 2164 1 No no DT cord-014516-r59usk02 2164 2 conflicts conflict NNS cord-014516-r59usk02 2164 3 of of IN cord-014516-r59usk02 2164 4 interest interest NN cord-014516-r59usk02 2164 5 reported report VBN cord-014516-r59usk02 2164 6 . . . cord-014516-r59usk02 2165 1 NT NT NNP cord-014516-r59usk02 2165 2 - - HYPH cord-014516-r59usk02 2165 3 proBNP proBNP NNP cord-014516-r59usk02 2165 4 has have VBZ cord-014516-r59usk02 2165 5 a a DT cord-014516-r59usk02 2165 6 degree degree NN cord-014516-r59usk02 2165 7 of of IN cord-014516-r59usk02 2165 8 overlap overlap NN cord-014516-r59usk02 2165 9 with with IN cord-014516-r59usk02 2165 10 clinically clinically RB cord-014516-r59usk02 2165 11 normal normal JJ cord-014516-r59usk02 2165 12 animals animal NNS cord-014516-r59usk02 2165 13 , , , cord-014516-r59usk02 2165 14 particularly particularly RB cord-014516-r59usk02 2165 15 those those DT cord-014516-r59usk02 2165 16 with with IN cord-014516-r59usk02 2165 17 mild mild JJ cord-014516-r59usk02 2165 18 or or CC cord-014516-r59usk02 2165 19 subclinical subclinical JJ cord-014516-r59usk02 2165 20 heart heart NN cord-014516-r59usk02 2165 21 disease disease NN cord-014516-r59usk02 2165 22 . . . cord-014516-r59usk02 2166 1 Prior prior JJ cord-014516-r59usk02 2166 2 studies study NNS cord-014516-r59usk02 2166 3 have have VBP cord-014516-r59usk02 2166 4 evaluated evaluate VBN cord-014516-r59usk02 2166 5 the the DT cord-014516-r59usk02 2166 6 sensitivity sensitivity NN cord-014516-r59usk02 2166 7 and and CC cord-014516-r59usk02 2166 8 specificity specificity NN cord-014516-r59usk02 2166 9 of of IN cord-014516-r59usk02 2166 10 a a DT cord-014516-r59usk02 2166 11 point point NN cord-014516-r59usk02 2166 12 - - HYPH cord-014516-r59usk02 2166 13 of of IN cord-014516-r59usk02 2166 14 - - HYPH cord-014516-r59usk02 2166 15 care care NN cord-014516-r59usk02 2166 16 second second JJ cord-014516-r59usk02 2166 17 generation generation NN cord-014516-r59usk02 2166 18 ELISA ELISA NNP cord-014516-r59usk02 2166 19 that that WDT cord-014516-r59usk02 2166 20 utilizes utilize VBZ cord-014516-r59usk02 2166 21 SNAP snap VB cord-014516-r59usk02 2166 22 technology technology NN cord-014516-r59usk02 2166 23 . . . cord-014516-r59usk02 2167 1 The the DT cord-014516-r59usk02 2167 2 SNAP snap JJ cord-014516-r59usk02 2167 3 Feline feline JJ cord-014516-r59usk02 2167 4 proBNP probnp NN cord-014516-r59usk02 2167 5 Test test NN cord-014516-r59usk02 2167 6 uses use VBZ cord-014516-r59usk02 2167 7 the the DT cord-014516-r59usk02 2167 8 same same JJ cord-014516-r59usk02 2167 9 biological biological JJ cord-014516-r59usk02 2167 10 reagents reagent NNS cord-014516-r59usk02 2167 11 as as IN cord-014516-r59usk02 2167 12 the the DT cord-014516-r59usk02 2167 13 Cardiopet Cardiopet NNP cord-014516-r59usk02 2167 14 proBNP probnp NN cord-014516-r59usk02 2167 15 Test Test NNP cord-014516-r59usk02 2167 16 but but CC cord-014516-r59usk02 2167 17 provides provide VBZ cord-014516-r59usk02 2167 18 results result NNS cord-014516-r59usk02 2167 19 in in IN cord-014516-r59usk02 2167 20 10 10 CD cord-014516-r59usk02 2167 21 minutes minute NNS cord-014516-r59usk02 2167 22 . . . cord-014516-r59usk02 2168 1 We -PRON- PRP cord-014516-r59usk02 2168 2 sought seek VBD cord-014516-r59usk02 2168 3 to to TO cord-014516-r59usk02 2168 4 prospectively prospectively RB cord-014516-r59usk02 2168 5 validate validate VB cord-014516-r59usk02 2168 6 the the DT cord-014516-r59usk02 2168 7 assay assay NN cord-014516-r59usk02 2168 8 in in IN cord-014516-r59usk02 2168 9 a a DT cord-014516-r59usk02 2168 10 population population NN cord-014516-r59usk02 2168 11 of of IN cord-014516-r59usk02 2168 12 clinically clinically RB cord-014516-r59usk02 2168 13 normal normal JJ cord-014516-r59usk02 2168 14 cats cat NNS cord-014516-r59usk02 2168 15 . . . cord-014516-r59usk02 2169 1 Cats cat NNS cord-014516-r59usk02 2169 2 were be VBD cord-014516-r59usk02 2169 3 recruited recruit VBN cord-014516-r59usk02 2169 4 based base VBN cord-014516-r59usk02 2169 5 upon upon IN cord-014516-r59usk02 2169 6 the the DT cord-014516-r59usk02 2169 7 absence absence NN cord-014516-r59usk02 2169 8 of of IN cord-014516-r59usk02 2169 9 a a DT cord-014516-r59usk02 2169 10 heart heart NN cord-014516-r59usk02 2169 11 murmur murmur NN cord-014516-r59usk02 2169 12 , , , cord-014516-r59usk02 2169 13 gallop gallop VBP cord-014516-r59usk02 2169 14 , , , cord-014516-r59usk02 2169 15 and/or and/or CC cord-014516-r59usk02 2169 16 arrhythmia arrhythmia NN cord-014516-r59usk02 2169 17 . . . cord-014516-r59usk02 2170 1 All all DT cord-014516-r59usk02 2170 2 cats cat NNS cord-014516-r59usk02 2170 3 received receive VBD cord-014516-r59usk02 2170 4 physical physical JJ cord-014516-r59usk02 2170 5 examination examination NN cord-014516-r59usk02 2170 6 , , , cord-014516-r59usk02 2170 7 non non JJ cord-014516-r59usk02 2170 8 - - JJ cord-014516-r59usk02 2170 9 invasive invasive JJ cord-014516-r59usk02 2170 10 blood blood NN cord-014516-r59usk02 2170 11 pressure pressure NN cord-014516-r59usk02 2170 12 measurement measurement NN cord-014516-r59usk02 2170 13 , , , cord-014516-r59usk02 2170 14 complete complete JJ cord-014516-r59usk02 2170 15 biochemical biochemical JJ cord-014516-r59usk02 2170 16 analysis analysis NN cord-014516-r59usk02 2170 17 including include VBG cord-014516-r59usk02 2170 18 a a DT cord-014516-r59usk02 2170 19 T4 T4 NNP cord-014516-r59usk02 2170 20 , , , cord-014516-r59usk02 2170 21 urinalysis urinalysis NN cord-014516-r59usk02 2170 22 and and CC cord-014516-r59usk02 2170 23 echocardiogram echocardiogram NN cord-014516-r59usk02 2170 24 . . . cord-014516-r59usk02 2171 1 Only only RB cord-014516-r59usk02 2171 2 cats cat NNS cord-014516-r59usk02 2171 3 considered consider VBD cord-014516-r59usk02 2171 4 free free JJ cord-014516-r59usk02 2171 5 of of IN cord-014516-r59usk02 2171 6 underlying underlie VBG cord-014516-r59usk02 2171 7 cardiac cardiac JJ cord-014516-r59usk02 2171 8 or or CC cord-014516-r59usk02 2171 9 systemic systemic JJ cord-014516-r59usk02 2171 10 disease disease NN cord-014516-r59usk02 2171 11 were be VBD cord-014516-r59usk02 2171 12 enrolled enrol VBN cord-014516-r59usk02 2171 13 . . . cord-014516-r59usk02 2172 1 Sixteen sixteen CD cord-014516-r59usk02 2172 2 adult adult NN cord-014516-r59usk02 2172 3 cats cat NNS cord-014516-r59usk02 2172 4 were be VBD cord-014516-r59usk02 2172 5 enrolled enrol VBN cord-014516-r59usk02 2172 6 and and CC cord-014516-r59usk02 2172 7 blood blood NN cord-014516-r59usk02 2172 8 samples sample NNS cord-014516-r59usk02 2172 9 were be VBD cord-014516-r59usk02 2172 10 obtained obtain VBN cord-014516-r59usk02 2172 11 for for IN cord-014516-r59usk02 2172 12 NT NT NNP cord-014516-r59usk02 2172 13 - - HYPH cord-014516-r59usk02 2172 14 proBNP probnp NN cord-014516-r59usk02 2172 15 concentrations concentration NNS cord-014516-r59usk02 2172 16 at at IN cord-014516-r59usk02 2172 17 0 0 CD cord-014516-r59usk02 2172 18 , , , cord-014516-r59usk02 2172 19 2 2 CD cord-014516-r59usk02 2172 20 hr hr NN cord-014516-r59usk02 2172 21 , , , cord-014516-r59usk02 2172 22 4 4 CD cord-014516-r59usk02 2172 23 hr hr NN cord-014516-r59usk02 2172 24 , , , cord-014516-r59usk02 2172 25 6 6 CD cord-014516-r59usk02 2172 26 hr hr NN cord-014516-r59usk02 2172 27 , , , cord-014516-r59usk02 2172 28 8 8 CD cord-014516-r59usk02 2172 29 hr hr NN cord-014516-r59usk02 2172 30 , , , cord-014516-r59usk02 2172 31 10 10 CD cord-014516-r59usk02 2172 32 hr hr NN cord-014516-r59usk02 2172 33 . . . cord-014516-r59usk02 2173 1 Samples sample NNS cord-014516-r59usk02 2173 2 were be VBD cord-014516-r59usk02 2173 3 placed place VBN cord-014516-r59usk02 2173 4 in in IN cord-014516-r59usk02 2173 5 EDTA EDTA NNP cord-014516-r59usk02 2173 6 tubes tube NNS cord-014516-r59usk02 2173 7 and and CC cord-014516-r59usk02 2173 8 centrifuged centrifuge VBD cord-014516-r59usk02 2173 9 within within IN cord-014516-r59usk02 2173 10 one one CD cord-014516-r59usk02 2173 11 hour hour NN cord-014516-r59usk02 2173 12 and and CC cord-014516-r59usk02 2173 13 split split VBD cord-014516-r59usk02 2173 14 into into IN cord-014516-r59usk02 2173 15 two two CD cord-014516-r59usk02 2173 16 tubes tube NNS cord-014516-r59usk02 2173 17 for for IN cord-014516-r59usk02 2173 18 duplicate duplicate JJ cord-014516-r59usk02 2173 19 samples sample NNS cord-014516-r59usk02 2173 20 at at IN cord-014516-r59usk02 2173 21 each each DT cord-014516-r59usk02 2173 22 time time NN cord-014516-r59usk02 2173 23 point point NN cord-014516-r59usk02 2173 24 and and CC cord-014516-r59usk02 2173 25 stored store VBN cord-014516-r59usk02 2173 26 at at IN cord-014516-r59usk02 2173 27 -80 -80 NNP cord-014516-r59usk02 2173 28 ° ° NN cord-014516-r59usk02 2173 29 C C NNP cord-014516-r59usk02 2173 30 . . . cord-014516-r59usk02 2174 1 Once once IN cord-014516-r59usk02 2174 2 all all DT cord-014516-r59usk02 2174 3 samples sample NNS cord-014516-r59usk02 2174 4 were be VBD cord-014516-r59usk02 2174 5 collected collect VBN cord-014516-r59usk02 2174 6 , , , cord-014516-r59usk02 2174 7 they -PRON- PRP cord-014516-r59usk02 2174 8 were be VBD cord-014516-r59usk02 2174 9 shipped ship VBN cord-014516-r59usk02 2174 10 on on IN cord-014516-r59usk02 2174 11 dry dry JJ cord-014516-r59usk02 2174 12 ice ice NN cord-014516-r59usk02 2174 13 overnight overnight RB cord-014516-r59usk02 2174 14 and and CC cord-014516-r59usk02 2174 15 run run VB cord-014516-r59usk02 2174 16 in in IN cord-014516-r59usk02 2174 17 one one CD cord-014516-r59usk02 2174 18 batch batch NN cord-014516-r59usk02 2174 19 ( ( -LRB- cord-014516-r59usk02 2174 20 IDEXX IDEXX NNP cord-014516-r59usk02 2174 21 Laboratories Laboratories NNP cord-014516-r59usk02 2174 22 ) ) -RRB- cord-014516-r59usk02 2174 23 for for IN cord-014516-r59usk02 2174 24 measurement measurement NN cord-014516-r59usk02 2174 25 of of IN cord-014516-r59usk02 2174 26 NT NT NNP cord-014516-r59usk02 2174 27 - - HYPH cord-014516-r59usk02 2174 28 proBNP probnp NN cord-014516-r59usk02 2174 29 concentrations concentration NNS cord-014516-r59usk02 2174 30 . . . cord-014516-r59usk02 2175 1 SNAP snap VB cord-014516-r59usk02 2175 2 tests test NNS cord-014516-r59usk02 2175 3 were be VBD cord-014516-r59usk02 2175 4 visually visually RB cord-014516-r59usk02 2175 5 evaluated evaluate VBN cord-014516-r59usk02 2175 6 by by IN cord-014516-r59usk02 2175 7 one one CD cord-014516-r59usk02 2175 8 blinded blind VBN cord-014516-r59usk02 2175 9 reader reader NN cord-014516-r59usk02 2175 10 . . . cord-014516-r59usk02 2176 1 Comparison comparison NN cord-014516-r59usk02 2176 2 of of IN cord-014516-r59usk02 2176 3 SNAP snap JJ cord-014516-r59usk02 2176 4 assay assay NN cord-014516-r59usk02 2176 5 vs. vs. IN cord-014516-r59usk02 2176 6 quantitative quantitative JJ cord-014516-r59usk02 2176 7 ELISA ELISA NNP cord-014516-r59usk02 2176 8 revealed reveal VBD cord-014516-r59usk02 2176 9 a a DT cord-014516-r59usk02 2176 10 1.0 1.0 CD cord-014516-r59usk02 2176 11 ( ( -LRB- cord-014516-r59usk02 2176 12 AUC AUC NNP cord-014516-r59usk02 2176 13 ) ) -RRB- cord-014516-r59usk02 2176 14 degree degree NN cord-014516-r59usk02 2176 15 of of IN cord-014516-r59usk02 2176 16 correlation correlation NN cord-014516-r59usk02 2176 17 between between IN cord-014516-r59usk02 2176 18 assays assay NNS cord-014516-r59usk02 2176 19 , , , cord-014516-r59usk02 2176 20 and and CC cord-014516-r59usk02 2176 21 that that IN cord-014516-r59usk02 2176 22 a a DT cord-014516-r59usk02 2176 23 positive positive JJ cord-014516-r59usk02 2176 24 SNAP snap JJ cord-014516-r59usk02 2176 25 test test NN cord-014516-r59usk02 2176 26 result result NN cord-014516-r59usk02 2176 27 was be VBD cord-014516-r59usk02 2176 28 associated associate VBN cord-014516-r59usk02 2176 29 with with IN cord-014516-r59usk02 2176 30 a a DT cord-014516-r59usk02 2176 31 NT NT NNP cord-014516-r59usk02 2176 32 - - HYPH cord-014516-r59usk02 2176 33 proBNP probnp NN cord-014516-r59usk02 2176 34 concentration concentration NN cord-014516-r59usk02 2176 35 of of IN cord-014516-r59usk02 2176 36 126.4pmol 126.4pmol CD cord-014516-r59usk02 2176 37 / / SYM cord-014516-r59usk02 2176 38 L l NN cord-014516-r59usk02 2176 39 or or CC cord-014516-r59usk02 2176 40 greater great JJR cord-014516-r59usk02 2176 41 . . . cord-014516-r59usk02 2177 1 The the DT cord-014516-r59usk02 2177 2 average average JJ cord-014516-r59usk02 2177 3 BNP BNP NNP cord-014516-r59usk02 2177 4 concentration concentration NN cord-014516-r59usk02 2177 5 of of IN cord-014516-r59usk02 2177 6 abnormal abnormal JJ cord-014516-r59usk02 2177 7 cats cat NNS cord-014516-r59usk02 2177 8 ( ( -LRB- cord-014516-r59usk02 2177 9 191.1 191.1 CD cord-014516-r59usk02 2177 10 AE AE NNP cord-014516-r59usk02 2177 11 5.8 5.8 CD cord-014516-r59usk02 2177 12 ) ) -RRB- cord-014516-r59usk02 2177 13 determined determine VBN cord-014516-r59usk02 2177 14 by by IN cord-014516-r59usk02 2177 15 the the DT cord-014516-r59usk02 2177 16 SNAP snap JJ cord-014516-r59usk02 2177 17 assay assay NN cord-014516-r59usk02 2177 18 was be VBD cord-014516-r59usk02 2177 19 significantly significantly RB cord-014516-r59usk02 2177 20 greater great JJR cord-014516-r59usk02 2177 21 than than IN cord-014516-r59usk02 2177 22 the the DT cord-014516-r59usk02 2177 23 normal normal JJ cord-014516-r59usk02 2177 24 ( ( -LRB- cord-014516-r59usk02 2177 25 26.4 26.4 CD cord-014516-r59usk02 2177 26 AE AE NNP cord-014516-r59usk02 2177 27 1.2 1.2 CD cord-014516-r59usk02 2177 28 ) ) -RRB- cord-014516-r59usk02 2177 29 . . . cord-014516-r59usk02 2178 1 This this DT cord-014516-r59usk02 2178 2 study study NN cord-014516-r59usk02 2178 3 was be VBD cord-014516-r59usk02 2178 4 funded fund VBN cord-014516-r59usk02 2178 5 through through IN cord-014516-r59usk02 2178 6 IDEXX IDEXX NNP cord-014516-r59usk02 2178 7 and and CC cord-014516-r59usk02 2178 8 the the DT cord-014516-r59usk02 2178 9 University University NNP cord-014516-r59usk02 2178 10 of of IN cord-014516-r59usk02 2178 11 Florida Florida NNP cord-014516-r59usk02 2178 12 College College NNP cord-014516-r59usk02 2178 13 of of IN cord-014516-r59usk02 2178 14 veterinary veterinary JJ cord-014516-r59usk02 2178 15 medicine medicine NN cord-014516-r59usk02 2178 16 resident resident NN cord-014516-r59usk02 2178 17 grant grant NN cord-014516-r59usk02 2178 18 competition competition NN cord-014516-r59usk02 2178 19 . . . cord-014516-r59usk02 2179 1 We -PRON- PRP cord-014516-r59usk02 2179 2 acquired acquire VBD cord-014516-r59usk02 2179 3 2D 2D NNP cord-014516-r59usk02 2179 4 echocardiographic echocardiographic NNP cord-014516-r59usk02 2179 5 cineloops cineloops NNP cord-014516-r59usk02 2179 6 from from IN cord-014516-r59usk02 2179 7 the the DT cord-014516-r59usk02 2179 8 left left JJ cord-014516-r59usk02 2179 9 apical apical JJ cord-014516-r59usk02 2179 10 4-chamber 4-chamber CD cord-014516-r59usk02 2179 11 view view NN cord-014516-r59usk02 2179 12 optimized optimize VBN cord-014516-r59usk02 2179 13 for for IN cord-014516-r59usk02 2179 14 the the DT cord-014516-r59usk02 2179 15 LA LA NNP cord-014516-r59usk02 2179 16 , , , cord-014516-r59usk02 2179 17 and and CC cord-014516-r59usk02 2179 18 analyzed analyze VBD cord-014516-r59usk02 2179 19 atrial atrial JJ cord-014516-r59usk02 2179 20 longitudinal longitudinal JJ cord-014516-r59usk02 2179 21 strain strain NN cord-014516-r59usk02 2179 22 ( ( -LRB- cord-014516-r59usk02 2179 23 St St NNP cord-014516-r59usk02 2179 24 ) ) -RRB- cord-014516-r59usk02 2179 25 and and CC cord-014516-r59usk02 2179 26 strain strain NN cord-014516-r59usk02 2179 27 rate rate NN cord-014516-r59usk02 2179 28 ( ( -LRB- cord-014516-r59usk02 2179 29 SR SR NNP cord-014516-r59usk02 2179 30 ) ) -RRB- cord-014516-r59usk02 2180 1 in in IN cord-014516-r59usk02 2180 2 27 27 CD cord-014516-r59usk02 2180 3 dogs dog NNS cord-014516-r59usk02 2180 4 ( ( -LRB- cord-014516-r59usk02 2180 5 10 10 CD cord-014516-r59usk02 2180 6 healthy healthy JJ cord-014516-r59usk02 2180 7 dogs dog NNS cord-014516-r59usk02 2180 8 and and CC cord-014516-r59usk02 2180 9 17 17 CD cord-014516-r59usk02 2180 10 dogs dog NNS cord-014516-r59usk02 2180 11 with with IN cord-014516-r59usk02 2180 12 MMVD MMVD NNP cord-014516-r59usk02 2180 13 -5 -5 NNP cord-014516-r59usk02 2180 14 ACVIM ACVIM NNP cord-014516-r59usk02 2180 15 Stage stage NN cord-014516-r59usk02 2180 16 B1 b1 NN cord-014516-r59usk02 2180 17 , , , cord-014516-r59usk02 2180 18 5 5 CD cord-014516-r59usk02 2180 19 Stage stage NN cord-014516-r59usk02 2180 20 B2 b2 NN cord-014516-r59usk02 2180 21 and and CC cord-014516-r59usk02 2180 22 7 7 CD cord-014516-r59usk02 2180 23 Stage stage NN cord-014516-r59usk02 2180 24 C C NNP cord-014516-r59usk02 2180 25 ) ) -RRB- cord-014516-r59usk02 2180 26 . . . cord-014516-r59usk02 2181 1 Endocardial Endocardial NNP cord-014516-r59usk02 2181 2 LA LA NNP cord-014516-r59usk02 2181 3 STE STE NNP cord-014516-r59usk02 2181 4 curves curve NNS cord-014516-r59usk02 2181 5 were be VBD cord-014516-r59usk02 2181 6 obtained obtain VBN cord-014516-r59usk02 2181 7 and and CC cord-014516-r59usk02 2181 8 peak peak JJ cord-014516-r59usk02 2181 9 atrial atrial JJ cord-014516-r59usk02 2181 10 longitudinal longitudinal JJ cord-014516-r59usk02 2181 11 strain strain NN cord-014516-r59usk02 2181 12 ( ( -LRB- cord-014516-r59usk02 2181 13 PALS pals NN cord-014516-r59usk02 2181 14 ) ) -RRB- cord-014516-r59usk02 2181 15 , , , cord-014516-r59usk02 2181 16 peak peak JJ cord-014516-r59usk02 2181 17 atrial atrial JJ cord-014516-r59usk02 2181 18 contraction contraction NN cord-014516-r59usk02 2181 19 strain strain NN cord-014516-r59usk02 2181 20 ( ( -LRB- cord-014516-r59usk02 2181 21 PACS PACS NNP cord-014516-r59usk02 2181 22 ) ) -RRB- cord-014516-r59usk02 2181 23 , , , cord-014516-r59usk02 2181 24 conduit conduit NN cord-014516-r59usk02 2181 25 atrial atrial JJ cord-014516-r59usk02 2181 26 longitudinal longitudinal JJ cord-014516-r59usk02 2181 27 strain strain NN cord-014516-r59usk02 2181 28 ( ( -LRB- cord-014516-r59usk02 2181 29 CALS CALS NNP cord-014516-r59usk02 2181 30 ) ) -RRB- cord-014516-r59usk02 2181 31 ; ; : cord-014516-r59usk02 2181 32 PALS pals NN cord-014516-r59usk02 2181 33 - - HYPH cord-014516-r59usk02 2181 34 PACS PACS NNPS cord-014516-r59usk02 2181 35 ) ) -RRB- cord-014516-r59usk02 2181 36 and and CC cord-014516-r59usk02 2181 37 contraction contraction NN cord-014516-r59usk02 2181 38 strain strain NN cord-014516-r59usk02 2181 39 index index NN cord-014516-r59usk02 2181 40 ( ( -LRB- cord-014516-r59usk02 2181 41 CSI CSI NNP cord-014516-r59usk02 2181 42 -PACS -PACS NNP cord-014516-r59usk02 2181 43 / / SYM cord-014516-r59usk02 2181 44 PALS*100 pals*100 NN cord-014516-r59usk02 2181 45 ) ) -RRB- cord-014516-r59usk02 2181 46 were be VBD cord-014516-r59usk02 2181 47 calculated calculate VBN cord-014516-r59usk02 2181 48 . . . cord-014516-r59usk02 2182 1 LA LA NNP cord-014516-r59usk02 2182 2 SR SR NNP cord-014516-r59usk02 2182 3 curves curve NNS cord-014516-r59usk02 2182 4 were be VBD cord-014516-r59usk02 2182 5 similarly similarly RB cord-014516-r59usk02 2182 6 obtained obtain VBN cord-014516-r59usk02 2182 7 to to TO cord-014516-r59usk02 2182 8 determine determine VB cord-014516-r59usk02 2182 9 the the DT cord-014516-r59usk02 2182 10 peak peak JJ cord-014516-r59usk02 2182 11 positive positive JJ cord-014516-r59usk02 2182 12 strain strain NN cord-014516-r59usk02 2182 13 rate rate NN cord-014516-r59usk02 2182 14 ( ( -LRB- cord-014516-r59usk02 2182 15 SRs sr NNS cord-014516-r59usk02 2182 16 ) ) -RRB- cord-014516-r59usk02 2182 17 during during IN cord-014516-r59usk02 2182 18 left left JJ cord-014516-r59usk02 2182 19 ventricle ventricle NN cord-014516-r59usk02 2182 20 systole systole NN cord-014516-r59usk02 2182 21 , , , cord-014516-r59usk02 2182 22 the the DT cord-014516-r59usk02 2182 23 first first JJ cord-014516-r59usk02 2182 24 negative negative JJ cord-014516-r59usk02 2182 25 peak peak NN cord-014516-r59usk02 2182 26 strain strain NN cord-014516-r59usk02 2182 27 rate rate NN cord-014516-r59usk02 2182 28 ( ( -LRB- cord-014516-r59usk02 2182 29 SRe sre NN cord-014516-r59usk02 2182 30 ) ) -RRB- cord-014516-r59usk02 2182 31 during during IN cord-014516-r59usk02 2182 32 early early JJ cord-014516-r59usk02 2182 33 diastole diastole NN cord-014516-r59usk02 2182 34 and and CC cord-014516-r59usk02 2182 35 the the DT cord-014516-r59usk02 2182 36 second second JJ cord-014516-r59usk02 2182 37 negative negative JJ cord-014516-r59usk02 2182 38 peak peak NN cord-014516-r59usk02 2182 39 strain strain NN cord-014516-r59usk02 2182 40 rate rate NN cord-014516-r59usk02 2182 41 ( ( -LRB- cord-014516-r59usk02 2182 42 SRa sra NN cord-014516-r59usk02 2182 43 ) ) -RRB- cord-014516-r59usk02 2182 44 during during IN cord-014516-r59usk02 2182 45 atrial atrial JJ cord-014516-r59usk02 2182 46 contraction contraction NN cord-014516-r59usk02 2182 47 . . . cord-014516-r59usk02 2183 1 For for IN cord-014516-r59usk02 2183 2 all all DT cord-014516-r59usk02 2183 3 variables variable NNS cord-014516-r59usk02 2183 4 , , , cord-014516-r59usk02 2183 5 a a DT cord-014516-r59usk02 2183 6 mean mean NN cord-014516-r59usk02 2183 7 of of IN cord-014516-r59usk02 2183 8 3 3 CD cord-014516-r59usk02 2183 9 measures measure NNS cord-014516-r59usk02 2183 10 was be VBD cord-014516-r59usk02 2183 11 used use VBN cord-014516-r59usk02 2183 12 for for IN cord-014516-r59usk02 2183 13 the the DT cord-014516-r59usk02 2183 14 statistical statistical JJ cord-014516-r59usk02 2183 15 analysis analysis NN cord-014516-r59usk02 2183 16 . . . cord-014516-r59usk02 2184 1 We -PRON- PRP cord-014516-r59usk02 2184 2 compared compare VBD cord-014516-r59usk02 2184 3 each each DT cord-014516-r59usk02 2184 4 of of IN cord-014516-r59usk02 2184 5 these these DT cord-014516-r59usk02 2184 6 variables variable NNS cord-014516-r59usk02 2184 7 between between IN cord-014516-r59usk02 2184 8 each each DT cord-014516-r59usk02 2184 9 ACVIM ACVIM NNP cord-014516-r59usk02 2184 10 stage stage NN cord-014516-r59usk02 2184 11 by by IN cord-014516-r59usk02 2184 12 Kruskal Kruskal NNP cord-014516-r59usk02 2184 13 - - HYPH cord-014516-r59usk02 2184 14 Wallis Wallis NNP cord-014516-r59usk02 2184 15 tests test NNS cord-014516-r59usk02 2184 16 and and CC cord-014516-r59usk02 2184 17 post post VB cord-014516-r59usk02 2184 18 - - JJ cord-014516-r59usk02 2184 19 hoc hoc JJ cord-014516-r59usk02 2184 20 pairwise pairwise JJ cord-014516-r59usk02 2184 21 comparisons comparison NNS cord-014516-r59usk02 2184 22 , , , cord-014516-r59usk02 2184 23 with with IN cord-014516-r59usk02 2184 24 comparison comparison NN cord-014516-r59usk02 2184 25 - - HYPH cord-014516-r59usk02 2184 26 wise wise JJ cord-014516-r59usk02 2184 27 a=0.05 a=0.05 NNP cord-014516-r59usk02 2184 28 . . . cord-014516-r59usk02 2185 1 Normal normal JJ cord-014516-r59usk02 2185 2 dogs dog NNS cord-014516-r59usk02 2185 3 had have VBD cord-014516-r59usk02 2185 4 higher high JJR cord-014516-r59usk02 2185 5 PALS pals NN cord-014516-r59usk02 2185 6 and and CC cord-014516-r59usk02 2185 7 CALS cal NNS cord-014516-r59usk02 2185 8 than than IN cord-014516-r59usk02 2185 9 dogs dog NNS cord-014516-r59usk02 2185 10 with with IN cord-014516-r59usk02 2185 11 MMVD MMVD NNP cord-014516-r59usk02 2185 12 ( ( -LRB- cord-014516-r59usk02 2185 13 p p NN cord-014516-r59usk02 2185 14 < < XX cord-014516-r59usk02 2185 15 0.0001 0.0001 CD cord-014516-r59usk02 2185 16 and and CC cord-014516-r59usk02 2185 17 p p NN cord-014516-r59usk02 2185 18 = = SYM cord-014516-r59usk02 2185 19 0.0005 0.0005 CD cord-014516-r59usk02 2185 20 ) ) -RRB- cord-014516-r59usk02 2185 21 ; ; : cord-014516-r59usk02 2185 22 Stage stage NN cord-014516-r59usk02 2185 23 C c NN cord-014516-r59usk02 2185 24 dogs dog NNS cord-014516-r59usk02 2185 25 had have VBD cord-014516-r59usk02 2185 26 lower low JJR cord-014516-r59usk02 2185 27 PALS pals NN cord-014516-r59usk02 2185 28 , , , cord-014516-r59usk02 2185 29 PACS PACS NNP cord-014516-r59usk02 2185 30 and and CC cord-014516-r59usk02 2185 31 CALS CALS NNP cord-014516-r59usk02 2185 32 than than IN cord-014516-r59usk02 2185 33 all all DT cord-014516-r59usk02 2185 34 other other JJ cord-014516-r59usk02 2185 35 dogs dog NNS cord-014516-r59usk02 2185 36 ( ( -LRB- cord-014516-r59usk02 2185 37 p p NN cord-014516-r59usk02 2185 38 < < XX cord-014516-r59usk02 2185 39 0.0001 0.0001 CD cord-014516-r59usk02 2185 40 , , , cord-014516-r59usk02 2185 41 p p NN cord-014516-r59usk02 2185 42 = = SYM cord-014516-r59usk02 2185 43 0.0022 0.0022 CD cord-014516-r59usk02 2185 44 and and CC cord-014516-r59usk02 2185 45 p p NN cord-014516-r59usk02 2185 46 = = SYM cord-014516-r59usk02 2185 47 0.0005 0.0005 CD cord-014516-r59usk02 2185 48 ) ) -RRB- cord-014516-r59usk02 2185 49 , , , cord-014516-r59usk02 2185 50 but but CC cord-014516-r59usk02 2185 51 CSI CSI NNP cord-014516-r59usk02 2185 52 did do VBD cord-014516-r59usk02 2185 53 not not RB cord-014516-r59usk02 2185 54 differ differ VB cord-014516-r59usk02 2185 55 between between IN cord-014516-r59usk02 2185 56 groups group NNS cord-014516-r59usk02 2185 57 ( ( -LRB- cord-014516-r59usk02 2185 58 p p NN cord-014516-r59usk02 2185 59 = = SYM cord-014516-r59usk02 2185 60 0.1 0.1 CD cord-014516-r59usk02 2185 61 ) ) -RRB- cord-014516-r59usk02 2185 62 . . . cord-014516-r59usk02 2186 1 Stage stage NN cord-014516-r59usk02 2186 2 C c NN cord-014516-r59usk02 2186 3 dogs dog NNS cord-014516-r59usk02 2186 4 had have VBD cord-014516-r59usk02 2186 5 lower low JJR cord-014516-r59usk02 2186 6 SRs sr NNS cord-014516-r59usk02 2186 7 ( ( -LRB- cord-014516-r59usk02 2186 8 p p NN cord-014516-r59usk02 2186 9 = = SYM cord-014516-r59usk02 2186 10 0.0005 0.0005 CD cord-014516-r59usk02 2186 11 ) ) -RRB- cord-014516-r59usk02 2186 12 , , , cord-014516-r59usk02 2186 13 higher high JJR cord-014516-r59usk02 2186 14 SRe SRe NNS cord-014516-r59usk02 2186 15 ( ( -LRB- cord-014516-r59usk02 2186 16 p p NN cord-014516-r59usk02 2186 17 = = SYM cord-014516-r59usk02 2186 18 0.0029 0.0029 CD cord-014516-r59usk02 2186 19 ) ) -RRB- cord-014516-r59usk02 2186 20 and and CC cord-014516-r59usk02 2186 21 SRa sra NN cord-014516-r59usk02 2186 22 ( ( -LRB- cord-014516-r59usk02 2186 23 p p NN cord-014516-r59usk02 2186 24 = = SYM cord-014516-r59usk02 2186 25 0.0004 0.0004 CD cord-014516-r59usk02 2186 26 ) ) -RRB- cord-014516-r59usk02 2186 27 than than IN cord-014516-r59usk02 2186 28 other other JJ cord-014516-r59usk02 2186 29 dogs dog NNS cord-014516-r59usk02 2186 30 . . . cord-014516-r59usk02 2187 1 Normal normal JJ cord-014516-r59usk02 2187 2 dogs dog NNS cord-014516-r59usk02 2187 3 had have VBD cord-014516-r59usk02 2187 4 lower low JJR cord-014516-r59usk02 2187 5 SRe SRe NNS cord-014516-r59usk02 2187 6 and and CC cord-014516-r59usk02 2187 7 SRa sra RB cord-014516-r59usk02 2187 8 than than IN cord-014516-r59usk02 2187 9 dogs dog NNS cord-014516-r59usk02 2187 10 with with IN cord-014516-r59usk02 2187 11 MMVD MMVD NNP cord-014516-r59usk02 2187 12 ( ( -LRB- cord-014516-r59usk02 2187 13 p p NN cord-014516-r59usk02 2187 14 < < XX cord-014516-r59usk02 2187 15 0.001 0.001 CD cord-014516-r59usk02 2187 16 ) ) -RRB- cord-014516-r59usk02 2187 17 . . . cord-014516-r59usk02 2188 1 Our -PRON- PRP$ cord-014516-r59usk02 2188 2 data datum NNS cord-014516-r59usk02 2188 3 suggest suggest VBP cord-014516-r59usk02 2188 4 that that IN cord-014516-r59usk02 2188 5 STE STE NNP cord-014516-r59usk02 2188 6 might may MD cord-014516-r59usk02 2188 7 be be VB cord-014516-r59usk02 2188 8 useful useful JJ cord-014516-r59usk02 2188 9 in in IN cord-014516-r59usk02 2188 10 assessing assess VBG cord-014516-r59usk02 2188 11 LA LA NNP cord-014516-r59usk02 2188 12 function function NN cord-014516-r59usk02 2188 13 in in IN cord-014516-r59usk02 2188 14 dogs dog NNS cord-014516-r59usk02 2188 15 with with IN cord-014516-r59usk02 2188 16 MMVD MMVD NNP cord-014516-r59usk02 2188 17 , , , cord-014516-r59usk02 2188 18 and and CC cord-014516-r59usk02 2188 19 might may MD cord-014516-r59usk02 2188 20 potentially potentially RB cord-014516-r59usk02 2188 21 differentiate differentiate VB cord-014516-r59usk02 2188 22 dogs dog NNS cord-014516-r59usk02 2188 23 with with IN cord-014516-r59usk02 2188 24 severe severe JJ cord-014516-r59usk02 2188 25 subclinical subclinical JJ cord-014516-r59usk02 2188 26 disease disease NN cord-014516-r59usk02 2188 27 from from IN cord-014516-r59usk02 2188 28 dogs dog NNS cord-014516-r59usk02 2188 29 with with IN cord-014516-r59usk02 2188 30 congestive congestive JJ cord-014516-r59usk02 2188 31 heart heart NN cord-014516-r59usk02 2188 32 failure failure NN cord-014516-r59usk02 2188 33 . . . cord-014516-r59usk02 2189 1 No no DT cord-014516-r59usk02 2189 2 conflicts conflict NNS cord-014516-r59usk02 2189 3 of of IN cord-014516-r59usk02 2189 4 interest interest NN cord-014516-r59usk02 2189 5 reported report VBN cord-014516-r59usk02 2189 6 . . . cord-014516-r59usk02 2190 1 Sighthounds sighthound NNS cord-014516-r59usk02 2190 2 are be VBP cord-014516-r59usk02 2190 3 athletic athletic JJ cord-014516-r59usk02 2190 4 dogs dog NNS cord-014516-r59usk02 2190 5 and and CC cord-014516-r59usk02 2190 6 they -PRON- PRP cord-014516-r59usk02 2190 7 have have VBP cord-014516-r59usk02 2190 8 been be VBN cord-014516-r59usk02 2190 9 claimed claim VBN cord-014516-r59usk02 2190 10 to to TO cord-014516-r59usk02 2190 11 have have VB cord-014516-r59usk02 2190 12 larger large JJR cord-014516-r59usk02 2190 13 hearts heart NNS cord-014516-r59usk02 2190 14 compared compare VBN cord-014516-r59usk02 2190 15 to to IN cord-014516-r59usk02 2190 16 similar similar JJ cord-014516-r59usk02 2190 17 sized sized JJ cord-014516-r59usk02 2190 18 breeds breed NNS cord-014516-r59usk02 2190 19 . . . cord-014516-r59usk02 2191 1 The the DT cord-014516-r59usk02 2191 2 left left JJ cord-014516-r59usk02 2191 3 ventricle ventricle NN cord-014516-r59usk02 2191 4 ( ( -LRB- cord-014516-r59usk02 2191 5 LV LV NNP cord-014516-r59usk02 2191 6 ) ) -RRB- cord-014516-r59usk02 2191 7 may may MD cord-014516-r59usk02 2191 8 enlarge enlarge VB cord-014516-r59usk02 2191 9 in in IN cord-014516-r59usk02 2191 10 response response NN cord-014516-r59usk02 2191 11 to to IN cord-014516-r59usk02 2191 12 cardiac cardiac JJ cord-014516-r59usk02 2191 13 disease disease NN cord-014516-r59usk02 2191 14 , , , cord-014516-r59usk02 2191 15 but but CC cord-014516-r59usk02 2191 16 also also RB cord-014516-r59usk02 2191 17 in in IN cord-014516-r59usk02 2191 18 response response NN cord-014516-r59usk02 2191 19 to to IN cord-014516-r59usk02 2191 20 training training NN cord-014516-r59usk02 2191 21 , , , cord-014516-r59usk02 2191 22 so so RB cord-014516-r59usk02 2191 23 called call VBN cord-014516-r59usk02 2191 24 athlete athlete NN cord-014516-r59usk02 2191 25 's 's POS cord-014516-r59usk02 2191 26 heart heart NN cord-014516-r59usk02 2191 27 syndrome syndrome NN cord-014516-r59usk02 2191 28 , , , cord-014516-r59usk02 2191 29 which which WDT cord-014516-r59usk02 2191 30 is be VBZ cord-014516-r59usk02 2191 31 a a DT cord-014516-r59usk02 2191 32 benign benign JJ cord-014516-r59usk02 2191 33 condition condition NN cord-014516-r59usk02 2191 34 . . . cord-014516-r59usk02 2192 1 To to TO cord-014516-r59usk02 2192 2 distinguish distinguish VB cord-014516-r59usk02 2192 3 abnormal abnormal JJ cord-014516-r59usk02 2192 4 echocardiographic echocardiographic JJ cord-014516-r59usk02 2192 5 measurements measurement NNS cord-014516-r59usk02 2192 6 from from IN cord-014516-r59usk02 2192 7 normal normal JJ cord-014516-r59usk02 2192 8 , , , cord-014516-r59usk02 2192 9 breed breed NN cord-014516-r59usk02 2192 10 - - HYPH cord-014516-r59usk02 2192 11 specific specific JJ cord-014516-r59usk02 2192 12 reference reference NN cord-014516-r59usk02 2192 13 values value NNS cord-014516-r59usk02 2192 14 are be VBP cord-014516-r59usk02 2192 15 needed need VBN cord-014516-r59usk02 2192 16 . . . cord-014516-r59usk02 2193 1 The the DT cord-014516-r59usk02 2193 2 aim aim NN cord-014516-r59usk02 2193 3 of of IN cord-014516-r59usk02 2193 4 this this DT cord-014516-r59usk02 2193 5 study study NN cord-014516-r59usk02 2193 6 is be VBZ cord-014516-r59usk02 2193 7 to to TO cord-014516-r59usk02 2193 8 establish establish VB cord-014516-r59usk02 2193 9 normal normal JJ cord-014516-r59usk02 2193 10 reference reference NN cord-014516-r59usk02 2193 11 ranges range NNS cord-014516-r59usk02 2193 12 for for IN cord-014516-r59usk02 2193 13 echocardiographic echocardiographic JJ cord-014516-r59usk02 2193 14 measurements measurement NNS cord-014516-r59usk02 2193 15 in in IN cord-014516-r59usk02 2193 16 the the DT cord-014516-r59usk02 2193 17 Saluki Saluki NNP cord-014516-r59usk02 2193 18 breed breed NN cord-014516-r59usk02 2193 19 . . . cord-014516-r59usk02 2194 1 The the DT cord-014516-r59usk02 2194 2 study study NN cord-014516-r59usk02 2194 3 comprised comprise VBD cord-014516-r59usk02 2194 4 78 78 CD cord-014516-r59usk02 2194 5 clinically clinically RB cord-014516-r59usk02 2194 6 healthy healthy JJ cord-014516-r59usk02 2194 7 Salukis Salukis NNPS cord-014516-r59usk02 2194 8 ( ( -LRB- cord-014516-r59usk02 2194 9 41 41 CD cord-014516-r59usk02 2194 10 males male NNS cord-014516-r59usk02 2194 11 and and CC cord-014516-r59usk02 2194 12 37 37 CD cord-014516-r59usk02 2194 13 females female NNS cord-014516-r59usk02 2194 14 ) ) -RRB- cord-014516-r59usk02 2194 15 , , . cord-014516-r59usk02 2195 1 mean mean VB cord-014516-r59usk02 2195 2 age age NN cord-014516-r59usk02 2195 3 72 72 CD cord-014516-r59usk02 2195 4 months month NNS cord-014516-r59usk02 2195 5 ( ( -LRB- cord-014516-r59usk02 2195 6 AE AE NNP cord-014516-r59usk02 2195 7 SD SD NNP cord-014516-r59usk02 2195 8 28 28 CD cord-014516-r59usk02 2195 9 months month NNS cord-014516-r59usk02 2195 10 ) ) -RRB- cord-014516-r59usk02 2195 11 , , , cord-014516-r59usk02 2195 12 bodyweight bodyweight NN cord-014516-r59usk02 2195 13 ( ( -LRB- cord-014516-r59usk02 2195 14 BW BW NNP cord-014516-r59usk02 2195 15 ) ) -RRB- cord-014516-r59usk02 2196 1 24,7 24,7 CD cord-014516-r59usk02 2196 2 kg kg NNP cord-014516-r59usk02 2196 3 ( ( -LRB- cord-014516-r59usk02 2196 4 AE AE NNP cord-014516-r59usk02 2196 5 3,7 3,7 CD cord-014516-r59usk02 2196 6 kg kg NNP cord-014516-r59usk02 2196 7 ) ) -RRB- cord-014516-r59usk02 2196 8 . . . cord-014516-r59usk02 2197 1 Case case NN cord-014516-r59usk02 2197 2 history history NN cord-014516-r59usk02 2197 3 was be VBD cord-014516-r59usk02 2197 4 ascertained ascertain VBN cord-014516-r59usk02 2197 5 and and CC cord-014516-r59usk02 2197 6 dogs dog NNS cord-014516-r59usk02 2197 7 underwent undergo VBD cord-014516-r59usk02 2197 8 physical physical JJ cord-014516-r59usk02 2197 9 examination examination NN cord-014516-r59usk02 2197 10 , , , cord-014516-r59usk02 2197 11 complete complete JJ cord-014516-r59usk02 2197 12 blood blood NN cord-014516-r59usk02 2197 13 count count NN cord-014516-r59usk02 2197 14 , , , cord-014516-r59usk02 2197 15 serum serum NN cord-014516-r59usk02 2197 16 biochemistry biochemistry NN cord-014516-r59usk02 2197 17 profile profile NN cord-014516-r59usk02 2197 18 , , , cord-014516-r59usk02 2197 19 thyroid thyroid NN cord-014516-r59usk02 2197 20 profile profile NN cord-014516-r59usk02 2197 21 , , , cord-014516-r59usk02 2197 22 blood blood NN cord-014516-r59usk02 2197 23 pressure pressure NN cord-014516-r59usk02 2197 24 measurement measurement NN cord-014516-r59usk02 2197 25 and and CC cord-014516-r59usk02 2197 26 3-min 3-min JJ cord-014516-r59usk02 2197 27 ECG ECG NNP cord-014516-r59usk02 2197 28 . . . cord-014516-r59usk02 2198 1 Standard Standard NNP cord-014516-r59usk02 2198 2 M M NNP cord-014516-r59usk02 2198 3 - - HYPH cord-014516-r59usk02 2198 4 mode mode NN cord-014516-r59usk02 2198 5 and and CC cord-014516-r59usk02 2198 6 2D 2D NNP cord-014516-r59usk02 2198 7 echocardiographic echocardiographic JJ cord-014516-r59usk02 2198 8 measurements measurement NNS cord-014516-r59usk02 2198 9 were be VBD cord-014516-r59usk02 2198 10 obtained obtain VBN cord-014516-r59usk02 2198 11 . . . cord-014516-r59usk02 2199 1 Dogs dog NNS cord-014516-r59usk02 2199 2 with with IN cord-014516-r59usk02 2199 3 systolic systolic JJ cord-014516-r59usk02 2199 4 murmur murmur NN cord-014516-r59usk02 2199 5 1/6 1/6 DT cord-014516-r59usk02 2199 6 , , , cord-014516-r59usk02 2199 7 and and CC cord-014516-r59usk02 2199 8 dogs dog NNS cord-014516-r59usk02 2199 9 with with IN cord-014516-r59usk02 2199 10 mitral mitral JJ cord-014516-r59usk02 2199 11 valve valve NN cord-014516-r59usk02 2199 12 regurgitation regurgitation NN cord-014516-r59usk02 2199 13 ( ( -LRB- cord-014516-r59usk02 2199 14 MR MR NNP cord-014516-r59usk02 2199 15 ) ) -RRB- cord-014516-r59usk02 2199 16 < < XX cord-014516-r59usk02 2199 17 15 15 CD cord-014516-r59usk02 2199 18 % % NN cord-014516-r59usk02 2199 19 ( ( -LRB- cord-014516-r59usk02 2199 20 MR MR NNP cord-014516-r59usk02 2199 21 color color NN cord-014516-r59usk02 2199 22 flow flow NN cord-014516-r59usk02 2199 23 jet jet NN cord-014516-r59usk02 2199 24 area area NN cord-014516-r59usk02 2199 25 / / SYM cord-014516-r59usk02 2199 26 left leave VBD cord-014516-r59usk02 2199 27 atrium atrium NNP cord-014516-r59usk02 2199 28 areax100 areax100 NNP cord-014516-r59usk02 2199 29 % % NN cord-014516-r59usk02 2199 30 in in IN cord-014516-r59usk02 2199 31 apical apical JJ cord-014516-r59usk02 2199 32 view view NN cord-014516-r59usk02 2199 33 ) ) -RRB- cord-014516-r59usk02 2199 34 were be VBD cord-014516-r59usk02 2199 35 considered consider VBN cord-014516-r59usk02 2199 36 normal normal JJ cord-014516-r59usk02 2199 37 . . . cord-014516-r59usk02 2200 1 Linear linear JJ cord-014516-r59usk02 2200 2 regression regression NN cord-014516-r59usk02 2200 3 models model NNS cord-014516-r59usk02 2200 4 were be VBD cord-014516-r59usk02 2200 5 used use VBN cord-014516-r59usk02 2200 6 to to TO cord-014516-r59usk02 2200 7 establish establish VB cord-014516-r59usk02 2200 8 reference reference NN cord-014516-r59usk02 2200 9 ranges range NNS cord-014516-r59usk02 2200 10 . . . cord-014516-r59usk02 2201 1 Heart heart NN cord-014516-r59usk02 2201 2 rate rate NN cord-014516-r59usk02 2201 3 ( ( -LRB- cord-014516-r59usk02 2201 4 HR hr NN cord-014516-r59usk02 2201 5 ) ) -RRB- cord-014516-r59usk02 2201 6 varied vary VBN cord-014516-r59usk02 2201 7 from from IN cord-014516-r59usk02 2201 8 44 44 CD cord-014516-r59usk02 2201 9 to to TO cord-014516-r59usk02 2201 10 120 120 CD cord-014516-r59usk02 2201 11 bpm bpm NN cord-014516-r59usk02 2201 12 ( ( -LRB- cord-014516-r59usk02 2201 13 81 81 CD cord-014516-r59usk02 2201 14 AE AE NNP cord-014516-r59usk02 2201 15 17 17 CD cord-014516-r59usk02 2201 16 bpm bpm NN cord-014516-r59usk02 2201 17 ) ) -RRB- cord-014516-r59usk02 2201 18 . . . cord-014516-r59usk02 2202 1 BW BW NNP cord-014516-r59usk02 2202 2 was be VBD cord-014516-r59usk02 2202 3 a a DT cord-014516-r59usk02 2202 4 significant significant JJ cord-014516-r59usk02 2202 5 predictor predictor NN cord-014516-r59usk02 2202 6 for for IN cord-014516-r59usk02 2202 7 LV LV NNP cord-014516-r59usk02 2202 8 dimensions dimension NNS cord-014516-r59usk02 2202 9 , , , cord-014516-r59usk02 2202 10 i.e. i.e. FW cord-014516-r59usk02 2202 11 M m NN cord-014516-r59usk02 2202 12 - - HYPH cord-014516-r59usk02 2202 13 mode mode NN cord-014516-r59usk02 2202 14 LV LV NNP cord-014516-r59usk02 2202 15 diameter diameter NN cord-014516-r59usk02 2202 16 and and CC cord-014516-r59usk02 2202 17 2D 2d JJ cord-014516-r59usk02 2202 18 volume volume NN cord-014516-r59usk02 2202 19 in in IN cord-014516-r59usk02 2202 20 diastole diastole NNP cord-014516-r59usk02 2202 21 ( ( -LRB- cord-014516-r59usk02 2202 22 LVIDD LVIDD NNP cord-014516-r59usk02 2202 23 and and CC cord-014516-r59usk02 2202 24 LVEDV LVEDV NNP cord-014516-r59usk02 2202 25 ) ) -RRB- cord-014516-r59usk02 2202 26 and and CC cord-014516-r59usk02 2202 27 systole systole NN cord-014516-r59usk02 2202 28 ( ( -LRB- cord-014516-r59usk02 2202 29 LVIDS LVIDS NNP cord-014516-r59usk02 2202 30 and and CC cord-014516-r59usk02 2202 31 LVESV LVESV NNP cord-014516-r59usk02 2202 32 ) ) -RRB- cord-014516-r59usk02 2202 33 , , , cord-014516-r59usk02 2202 34 and and CC cord-014516-r59usk02 2202 35 mitral mitral JJ cord-014516-r59usk02 2202 36 valve valve NN cord-014516-r59usk02 2202 37 end end NN cord-014516-r59usk02 2202 38 point point NN cord-014516-r59usk02 2202 39 septal septal JJ cord-014516-r59usk02 2202 40 separation separation NN cord-014516-r59usk02 2202 41 ( ( -LRB- cord-014516-r59usk02 2202 42 EPSS EPSS NNP cord-014516-r59usk02 2202 43 ) ) -RRB- cord-014516-r59usk02 2202 44 . . . cord-014516-r59usk02 2203 1 HR HR NNP cord-014516-r59usk02 2203 2 was be VBD cord-014516-r59usk02 2203 3 a a DT cord-014516-r59usk02 2203 4 significant significant JJ cord-014516-r59usk02 2203 5 predictor predictor NN cord-014516-r59usk02 2203 6 for for IN cord-014516-r59usk02 2203 7 FS fs NN cord-014516-r59usk02 2203 8 % % NN cord-014516-r59usk02 2203 9 ( ( -LRB- cord-014516-r59usk02 2203 10 fractional fractional JJ cord-014516-r59usk02 2203 11 shortening shortening NN cord-014516-r59usk02 2203 12 ) ) -RRB- cord-014516-r59usk02 2203 13 . . . cord-014516-r59usk02 2204 1 Predicted predict VBN cord-014516-r59usk02 2204 2 values value NNS cord-014516-r59usk02 2204 3 ( ( -LRB- cord-014516-r59usk02 2204 4 95 95 CD cord-014516-r59usk02 2204 5 % % NN cord-014516-r59usk02 2204 6 prediction prediction NN cord-014516-r59usk02 2204 7 intervals interval NNS cord-014516-r59usk02 2204 8 ) ) -RRB- cord-014516-r59usk02 2204 9 were be VBD cord-014516-r59usk02 2204 10 calculated calculate VBN cord-014516-r59usk02 2204 11 from from IN cord-014516-r59usk02 2204 12 regression regression NN cord-014516-r59usk02 2204 13 models model NNS cord-014516-r59usk02 2204 14 where where WRB cord-014516-r59usk02 2204 15 mean mean VBP cord-014516-r59usk02 2204 16 BW BW NNP cord-014516-r59usk02 2204 17 ( ( -LRB- cord-014516-r59usk02 2204 18 24,7 24,7 CD cord-014516-r59usk02 2204 19 kg kg NN cord-014516-r59usk02 2204 20 ) ) -RRB- cord-014516-r59usk02 2204 21 and and CC cord-014516-r59usk02 2204 22 age age NN cord-014516-r59usk02 2204 23 ( ( -LRB- cord-014516-r59usk02 2204 24 72 72 CD cord-014516-r59usk02 2204 25 months month NNS cord-014516-r59usk02 2204 26 ) ) -RRB- cord-014516-r59usk02 2204 27 , , , cord-014516-r59usk02 2204 28 and and CC cord-014516-r59usk02 2204 29 median median JJ cord-014516-r59usk02 2204 30 HR hr NN cord-014516-r59usk02 2204 31 ( ( -LRB- cord-014516-r59usk02 2204 32 80 80 CD cord-014516-r59usk02 2204 33 bpm bpm NN cord-014516-r59usk02 2204 34 ) ) -RRB- cord-014516-r59usk02 2204 35 were be VBD cord-014516-r59usk02 2204 36 used use VBN cord-014516-r59usk02 2204 37 . . . cord-014516-r59usk02 2205 1 Normal normal JJ cord-014516-r59usk02 2205 2 reference reference NN cord-014516-r59usk02 2205 3 ranges range NNS cord-014516-r59usk02 2205 4 were be VBD cord-014516-r59usk02 2205 5 : : : cord-014516-r59usk02 2205 6 LVIDD LVIDD NNP cord-014516-r59usk02 2205 7 46,0 46,0 CD cord-014516-r59usk02 2205 8 mm mm NNP cord-014516-r59usk02 2205 9 ( ( -LRB- cord-014516-r59usk02 2205 10 40,0 40,0 CD cord-014516-r59usk02 2205 11 - - SYM cord-014516-r59usk02 2205 12 52,0 52,0 CD cord-014516-r59usk02 2205 13 ) ) -RRB- cord-014516-r59usk02 2205 14 , , , cord-014516-r59usk02 2205 15 LVIDS LVIDS NNP cord-014516-r59usk02 2205 16 33 33 CD cord-014516-r59usk02 2205 17 , , , cord-014516-r59usk02 2205 18 4 4 CD cord-014516-r59usk02 2205 19 mm mm NN cord-014516-r59usk02 2205 20 ( ( -LRB- cord-014516-r59usk02 2205 21 27 27 CD cord-014516-r59usk02 2205 22 , , , cord-014516-r59usk02 2205 23 5 5 CD cord-014516-r59usk02 2205 24 ) ) -RRB- cord-014516-r59usk02 2205 25 , , , cord-014516-r59usk02 2205 26 LVEDV LVEDV NNP cord-014516-r59usk02 2205 27 86,3 86,3 CD cord-014516-r59usk02 2205 28 ml ml NNP cord-014516-r59usk02 2205 29 ( ( -LRB- cord-014516-r59usk02 2205 30 64,6 64,6 CD cord-014516-r59usk02 2205 31 - - SYM cord-014516-r59usk02 2205 32 108,0 108,0 CD cord-014516-r59usk02 2205 33 ) ) -RRB- cord-014516-r59usk02 2205 34 , , . cord-014516-r59usk02 2206 1 LVESV LVESV NNP cord-014516-r59usk02 2206 2 44,2 44,2 CD cord-014516-r59usk02 2206 3 ml ml NN cord-014516-r59usk02 2206 4 ( ( -LRB- cord-014516-r59usk02 2206 5 29,2 29,2 CD cord-014516-r59usk02 2206 6 - - HYPH cord-014516-r59usk02 2206 7 59,2 59,2 CD cord-014516-r59usk02 2206 8 ) ) -RRB- cord-014516-r59usk02 2206 9 , , . cord-014516-r59usk02 2207 1 FS% FS% NNP cord-014516-r59usk02 2207 2 : : : cord-014516-r59usk02 2208 1 27,5 27,5 CD cord-014516-r59usk02 2208 2 % % NN cord-014516-r59usk02 2208 3 ( ( -LRB- cord-014516-r59usk02 2208 4 20,3 20,3 CD cord-014516-r59usk02 2208 5 - - HYPH cord-014516-r59usk02 2208 6 34,6 34,6 CD cord-014516-r59usk02 2208 7 ) ) -RRB- cord-014516-r59usk02 2208 8 , , , cord-014516-r59usk02 2208 9 ejection ejection NN cord-014516-r59usk02 2208 10 fraction fraction NN cord-014516-r59usk02 2208 11 EF% EF% NNS cord-014516-r59usk02 2208 12 : : : cord-014516-r59usk02 2209 1 48,9 48,9 CD cord-014516-r59usk02 2209 2 % % NN cord-014516-r59usk02 2209 3 ( ( -LRB- cord-014516-r59usk02 2209 4 38,6 38,6 CD cord-014516-r59usk02 2209 5 - - HYPH cord-014516-r59usk02 2209 6 59,1 59,1 CD cord-014516-r59usk02 2209 7 ) ) -RRB- cord-014516-r59usk02 2209 8 , , , cord-014516-r59usk02 2209 9 EPSS EPSS NNP cord-014516-r59usk02 2209 10 7,3 7,3 CD cord-014516-r59usk02 2209 11 mm mm NN cord-014516-r59usk02 2209 12 ( ( -LRB- cord-014516-r59usk02 2209 13 4,4 4,4 CD cord-014516-r59usk02 2209 14 - - SYM cord-014516-r59usk02 2209 15 10,2 10,2 CD cord-014516-r59usk02 2209 16 ) ) -RRB- cord-014516-r59usk02 2209 17 , , , cord-014516-r59usk02 2209 18 sphericity sphericity NN cord-014516-r59usk02 2209 19 index index NN cord-014516-r59usk02 2209 20 1,6 1,6 CD cord-014516-r59usk02 2209 21 ( ( -LRB- cord-014516-r59usk02 2209 22 1,4 1,4 CD cord-014516-r59usk02 2209 23 - - HYPH cord-014516-r59usk02 2209 24 1,9 1,9 CD cord-014516-r59usk02 2209 25 ) ) -RRB- cord-014516-r59usk02 2209 26 , , , cord-014516-r59usk02 2209 27 interventricular interventricular JJ cord-014516-r59usk02 2209 28 septum septum NN cord-014516-r59usk02 2209 29 in in IN cord-014516-r59usk02 2209 30 diastole diastole NN cord-014516-r59usk02 2209 31 10,9 10,9 CD cord-014516-r59usk02 2209 32 mm mm NN cord-014516-r59usk02 2209 33 ( ( -LRB- cord-014516-r59usk02 2209 34 8,6 8,6 CD cord-014516-r59usk02 2209 35 - - HYPH cord-014516-r59usk02 2209 36 13,3 13,3 CD cord-014516-r59usk02 2209 37 ) ) -RRB- cord-014516-r59usk02 2209 38 and and CC cord-014516-r59usk02 2209 39 systole systole NN cord-014516-r59usk02 2209 40 13,8 13,8 CD cord-014516-r59usk02 2209 41 mm mm NNP cord-014516-r59usk02 2209 42 ( ( -LRB- cord-014516-r59usk02 2209 43 10,5 10,5 CD cord-014516-r59usk02 2209 44 - - SYM cord-014516-r59usk02 2209 45 17,1 17,1 CD cord-014516-r59usk02 2209 46 ) ) -RRB- cord-014516-r59usk02 2209 47 , , , cord-014516-r59usk02 2209 48 LV LV NNP cord-014516-r59usk02 2209 49 free free JJ cord-014516-r59usk02 2209 50 wall wall NN cord-014516-r59usk02 2209 51 in in IN cord-014516-r59usk02 2209 52 diastole diastole NN cord-014516-r59usk02 2210 1 10,4 10,4 LS cord-014516-r59usk02 2210 2 mm mm NNP cord-014516-r59usk02 2210 3 ( ( -LRB- cord-014516-r59usk02 2210 4 8,3 8,3 CD cord-014516-r59usk02 2210 5 - - SYM cord-014516-r59usk02 2210 6 12,4 12,4 CD cord-014516-r59usk02 2210 7 ) ) -RRB- cord-014516-r59usk02 2210 8 and and CC cord-014516-r59usk02 2210 9 systole systole NN cord-014516-r59usk02 2210 10 13,1 13,1 CD cord-014516-r59usk02 2211 1 mm mm NNP cord-014516-r59usk02 2212 1 ( ( -LRB- cord-014516-r59usk02 2212 2 10,0 10,0 CD cord-014516-r59usk02 2212 3 - - SYM cord-014516-r59usk02 2212 4 16,1 16,1 CD cord-014516-r59usk02 2212 5 ) ) -RRB- cord-014516-r59usk02 2212 6 , , . cord-014516-r59usk02 2213 1 left leave VBN cord-014516-r59usk02 2214 1 atrial atrial JJ cord-014516-r59usk02 2214 2 ( ( -LRB- cord-014516-r59usk02 2214 3 LA LA NNP cord-014516-r59usk02 2214 4 ) ) -RRB- cord-014516-r59usk02 2214 5 diameter diameter NN cord-014516-r59usk02 2214 6 28,5 28,5 CD cord-014516-r59usk02 2214 7 mm mm NN cord-014516-r59usk02 2214 8 ( ( -LRB- cord-014516-r59usk02 2214 9 23 23 CD cord-014516-r59usk02 2214 10 , , , cord-014516-r59usk02 2214 11 3 3 CD cord-014516-r59usk02 2214 12 ) ) -RRB- cord-014516-r59usk02 2214 13 , , , cord-014516-r59usk02 2214 14 aortic aortic JJ cord-014516-r59usk02 2214 15 ( ( -LRB- cord-014516-r59usk02 2214 16 Ao Ao NNP cord-014516-r59usk02 2214 17 ) ) -RRB- cord-014516-r59usk02 2214 18 diameter diameter NN cord-014516-r59usk02 2215 1 23,9 23,9 CD cord-014516-r59usk02 2215 2 mm mm NN cord-014516-r59usk02 2216 1 ( ( -LRB- cord-014516-r59usk02 2216 2 20,1 20,1 CD cord-014516-r59usk02 2216 3 - - SYM cord-014516-r59usk02 2216 4 27,8 27,8 CD cord-014516-r59usk02 2216 5 ) ) -RRB- cord-014516-r59usk02 2216 6 , , . cord-014516-r59usk02 2217 1 LA LA NNP cord-014516-r59usk02 2217 2 / / SYM cord-014516-r59usk02 2217 3 Ao Ao NNP cord-014516-r59usk02 2217 4 1,2 1,2 CD cord-014516-r59usk02 2218 1 ( ( -LRB- cord-014516-r59usk02 2218 2 1,0 1,0 CD cord-014516-r59usk02 2218 3 - - HYPH cord-014516-r59usk02 2218 4 1,4 1,4 CD cord-014516-r59usk02 2218 5 ) ) -RRB- cord-014516-r59usk02 2218 6 , , , cord-014516-r59usk02 2218 7 and and CC cord-014516-r59usk02 2218 8 aortic aortic JJ cord-014516-r59usk02 2218 9 and and CC cord-014516-r59usk02 2218 10 pulmonic pulmonic JJ cord-014516-r59usk02 2218 11 flow flow NN cord-014516-r59usk02 2218 12 velocity velocity NN cord-014516-r59usk02 2218 13 1,4 1,4 CD cord-014516-r59usk02 2218 14 m m NN cord-014516-r59usk02 2218 15 / / SYM cord-014516-r59usk02 2218 16 s s NN cord-014516-r59usk02 2218 17 ( ( -LRB- cord-014516-r59usk02 2218 18 0 0 CD cord-014516-r59usk02 2218 19 , , , cord-014516-r59usk02 2218 20 9 9 CD cord-014516-r59usk02 2218 21 ) ) -RRB- cord-014516-r59usk02 2218 22 and and CC cord-014516-r59usk02 2218 23 1,2 1,2 CD cord-014516-r59usk02 2218 24 m m NN cord-014516-r59usk02 2218 25 / / SYM cord-014516-r59usk02 2218 26 s s NN cord-014516-r59usk02 2219 1 ( ( -LRB- cord-014516-r59usk02 2219 2 0,8 0,8 CD cord-014516-r59usk02 2219 3 - - SYM cord-014516-r59usk02 2219 4 1,6 1,6 CD cord-014516-r59usk02 2219 5 ) ) -RRB- cord-014516-r59usk02 2219 6 , , . cord-014516-r59usk02 2220 1 respectively respectively RB cord-014516-r59usk02 2220 2 . . . cord-014516-r59usk02 2221 1 This this DT cord-014516-r59usk02 2221 2 study study NN cord-014516-r59usk02 2221 3 provides provide VBZ cord-014516-r59usk02 2221 4 echocardiographic echocardiographic JJ cord-014516-r59usk02 2221 5 values value NNS cord-014516-r59usk02 2221 6 for for IN cord-014516-r59usk02 2221 7 normal normal JJ cord-014516-r59usk02 2221 8 Salukis Salukis NNP cord-014516-r59usk02 2221 9 which which WDT cord-014516-r59usk02 2221 10 can can MD cord-014516-r59usk02 2221 11 be be VB cord-014516-r59usk02 2221 12 used use VBN cord-014516-r59usk02 2221 13 as as IN cord-014516-r59usk02 2221 14 a a DT cord-014516-r59usk02 2221 15 reference reference NN cord-014516-r59usk02 2221 16 values value NNS cord-014516-r59usk02 2221 17 . . . cord-014516-r59usk02 2222 1 No no DT cord-014516-r59usk02 2222 2 conflicts conflict NNS cord-014516-r59usk02 2222 3 of of IN cord-014516-r59usk02 2222 4 interest interest NN cord-014516-r59usk02 2222 5 reported report VBN cord-014516-r59usk02 2222 6 . . . cord-014516-r59usk02 2223 1 In in IN cord-014516-r59usk02 2223 2 mitral mitral JJ cord-014516-r59usk02 2223 3 valve valve NN cord-014516-r59usk02 2223 4 disease disease NN cord-014516-r59usk02 2223 5 , , , cord-014516-r59usk02 2223 6 atrial atrial JJ cord-014516-r59usk02 2223 7 remodeling remodeling NN cord-014516-r59usk02 2223 8 is be VBZ cord-014516-r59usk02 2223 9 an an DT cord-014516-r59usk02 2223 10 indicator indicator NN cord-014516-r59usk02 2223 11 of of IN cord-014516-r59usk02 2223 12 evolution evolution NN cord-014516-r59usk02 2223 13 and and CC cord-014516-r59usk02 2223 14 prognosis prognosis NN cord-014516-r59usk02 2223 15 , , , cord-014516-r59usk02 2223 16 the the DT cord-014516-r59usk02 2223 17 duration duration NN cord-014516-r59usk02 2223 18 of of IN cord-014516-r59usk02 2223 19 the the DT cord-014516-r59usk02 2223 20 P p NN cord-014516-r59usk02 2223 21 wave wave NN cord-014516-r59usk02 2223 22 being be VBG cord-014516-r59usk02 2223 23 considered consider VBN cord-014516-r59usk02 2223 24 suggestive suggestive JJ cord-014516-r59usk02 2223 25 of of IN cord-014516-r59usk02 2223 26 the the DT cord-014516-r59usk02 2223 27 dilatation dilatation NN cord-014516-r59usk02 2223 28 of of IN cord-014516-r59usk02 2223 29 the the DT cord-014516-r59usk02 2223 30 left left JJ cord-014516-r59usk02 2223 31 atrium atrium NN cord-014516-r59usk02 2223 32 . . . cord-014516-r59usk02 2224 1 In in IN cord-014516-r59usk02 2224 2 humans human NNS cord-014516-r59usk02 2224 3 ' ' POS cord-014516-r59usk02 2224 4 studies study NNS cord-014516-r59usk02 2224 5 , , , cord-014516-r59usk02 2224 6 neurological neurological JJ cord-014516-r59usk02 2224 7 conditions condition NNS cord-014516-r59usk02 2224 8 have have VBP cord-014516-r59usk02 2224 9 a a DT cord-014516-r59usk02 2224 10 significant significant JJ cord-014516-r59usk02 2224 11 impact impact NN cord-014516-r59usk02 2224 12 on on IN cord-014516-r59usk02 2224 13 cardiac cardiac JJ cord-014516-r59usk02 2224 14 electrophysiology electrophysiology NN cord-014516-r59usk02 2224 15 by by IN cord-014516-r59usk02 2224 16 altering alter VBG cord-014516-r59usk02 2224 17 the the DT cord-014516-r59usk02 2224 18 electrical electrical JJ cord-014516-r59usk02 2224 19 impulse impulse NN cord-014516-r59usk02 2224 20 conductibility conductibility NN cord-014516-r59usk02 2224 21 . . . cord-014516-r59usk02 2225 1 The the DT cord-014516-r59usk02 2225 2 aim aim NN cord-014516-r59usk02 2225 3 of of IN cord-014516-r59usk02 2225 4 this this DT cord-014516-r59usk02 2225 5 study study NN cord-014516-r59usk02 2225 6 is be VBZ cord-014516-r59usk02 2225 7 to to TO cord-014516-r59usk02 2225 8 examine examine VB cord-014516-r59usk02 2225 9 the the DT cord-014516-r59usk02 2225 10 duration duration NN cord-014516-r59usk02 2225 11 of of IN cord-014516-r59usk02 2225 12 the the DT cord-014516-r59usk02 2225 13 P p NN cord-014516-r59usk02 2225 14 wave wave NN cord-014516-r59usk02 2225 15 in in IN cord-014516-r59usk02 2225 16 dogs dog NNS cord-014516-r59usk02 2225 17 suffering suffer VBG cord-014516-r59usk02 2225 18 from from IN cord-014516-r59usk02 2225 19 mitral mitral JJ cord-014516-r59usk02 2225 20 valve valve NN cord-014516-r59usk02 2225 21 disease disease NN cord-014516-r59usk02 2225 22 in in IN cord-014516-r59usk02 2225 23 comparison comparison NN cord-014516-r59usk02 2225 24 to to IN cord-014516-r59usk02 2225 25 dogs dog NNS cord-014516-r59usk02 2225 26 diagnosed diagnose VBN cord-014516-r59usk02 2225 27 with with IN cord-014516-r59usk02 2225 28 different different JJ cord-014516-r59usk02 2225 29 neuropathies neuropathy NNS cord-014516-r59usk02 2225 30 without without IN cord-014516-r59usk02 2225 31 cardiac cardiac JJ cord-014516-r59usk02 2225 32 abnormalities abnormality NNS cord-014516-r59usk02 2225 33 . . . cord-014516-r59usk02 2226 1 We -PRON- PRP cord-014516-r59usk02 2226 2 analyzed analyze VBD cord-014516-r59usk02 2226 3 standard standard JJ cord-014516-r59usk02 2226 4 electrocardiograms electrocardiogram NNS cord-014516-r59usk02 2226 5 ( ( -LRB- cord-014516-r59usk02 2226 6 5 5 CD cord-014516-r59usk02 2226 7 min min NN cord-014516-r59usk02 2226 8 of of IN cord-014516-r59usk02 2226 9 ECG ECG NNP cord-014516-r59usk02 2226 10 , , , cord-014516-r59usk02 2226 11 on on IN cord-014516-r59usk02 2226 12 6 6 CD cord-014516-r59usk02 2226 13 peripheral peripheral JJ cord-014516-r59usk02 2226 14 leads lead NNS cord-014516-r59usk02 2226 15 ) ) -RRB- cord-014516-r59usk02 2226 16 performed perform VBN cord-014516-r59usk02 2226 17 on on IN cord-014516-r59usk02 2226 18 three three CD cord-014516-r59usk02 2226 19 polymorphic polymorphic JJ cord-014516-r59usk02 2226 20 groups group NNS cord-014516-r59usk02 2226 21 of of IN cord-014516-r59usk02 2226 22 dogs dog NNS cord-014516-r59usk02 2226 23 ( ( -LRB- cord-014516-r59usk02 2226 24 different different JJ cord-014516-r59usk02 2226 25 age age NN cord-014516-r59usk02 2226 26 , , , cord-014516-r59usk02 2226 27 weight weight NN cord-014516-r59usk02 2226 28 and and CC cord-014516-r59usk02 2226 29 breed breed NN cord-014516-r59usk02 2226 30 ) ) -RRB- cord-014516-r59usk02 2226 31 : : : cord-014516-r59usk02 2226 32 group group NN cord-014516-r59usk02 2226 33 1 1 CD cord-014516-r59usk02 2226 34 ( ( -LRB- cord-014516-r59usk02 2226 35 n n NN cord-014516-r59usk02 2226 36 = = SYM cord-014516-r59usk02 2226 37 14 14 CD cord-014516-r59usk02 2226 38 ) ) -RRB- cord-014516-r59usk02 2227 1 healthy healthy JJ cord-014516-r59usk02 2227 2 dogs dog NNS cord-014516-r59usk02 2227 3 , , , cord-014516-r59usk02 2227 4 group group NN cord-014516-r59usk02 2227 5 2 2 CD cord-014516-r59usk02 2227 6 ( ( -LRB- cord-014516-r59usk02 2227 7 n n NN cord-014516-r59usk02 2227 8 = = SYM cord-014516-r59usk02 2227 9 30 30 CD cord-014516-r59usk02 2227 10 ) ) -RRB- cord-014516-r59usk02 2227 11 dogs dog NNS cord-014516-r59usk02 2227 12 diagnosed diagnose VBN cord-014516-r59usk02 2227 13 with with IN cord-014516-r59usk02 2227 14 mitral mitral JJ cord-014516-r59usk02 2227 15 valve valve NN cord-014516-r59usk02 2227 16 disease disease NN cord-014516-r59usk02 2227 17 and and CC cord-014516-r59usk02 2227 18 group group NN cord-014516-r59usk02 2227 19 3 3 CD cord-014516-r59usk02 2227 20 ( ( -LRB- cord-014516-r59usk02 2227 21 n n NN cord-014516-r59usk02 2227 22 = = SYM cord-014516-r59usk02 2227 23 27 27 CD cord-014516-r59usk02 2227 24 ) ) -RRB- cord-014516-r59usk02 2227 25 dogs dog NNS cord-014516-r59usk02 2227 26 suffering suffer VBG cord-014516-r59usk02 2227 27 from from IN cord-014516-r59usk02 2227 28 different different JJ cord-014516-r59usk02 2227 29 neuropathies neuropathy NNS cord-014516-r59usk02 2227 30 ( ( -LRB- cord-014516-r59usk02 2227 31 without without IN cord-014516-r59usk02 2227 32 any any DT cord-014516-r59usk02 2227 33 associated associated JJ cord-014516-r59usk02 2227 34 or or CC cord-014516-r59usk02 2227 35 previously previously RB cord-014516-r59usk02 2227 36 diagnosed diagnose VBN cord-014516-r59usk02 2227 37 cardiovascular cardiovascular JJ cord-014516-r59usk02 2227 38 disease disease NN cord-014516-r59usk02 2227 39 ) ) -RRB- cord-014516-r59usk02 2227 40 . . . cord-014516-r59usk02 2228 1 The the DT cord-014516-r59usk02 2228 2 duration duration NN cord-014516-r59usk02 2228 3 of of IN cord-014516-r59usk02 2228 4 the the DT cord-014516-r59usk02 2228 5 P p NN cord-014516-r59usk02 2228 6 wave wave NN cord-014516-r59usk02 2228 7 was be VBD cord-014516-r59usk02 2228 8 measured measure VBN cord-014516-r59usk02 2228 9 for for IN cord-014516-r59usk02 2228 10 all all DT cord-014516-r59usk02 2228 11 dogs dog NNS cord-014516-r59usk02 2228 12 ( ( -LRB- cord-014516-r59usk02 2228 13 five five CD cord-014516-r59usk02 2228 14 consecutive consecutive JJ cord-014516-r59usk02 2228 15 P p NN cord-014516-r59usk02 2228 16 waves wave NNS cord-014516-r59usk02 2228 17 without without IN cord-014516-r59usk02 2228 18 anomalies anomaly NNS cord-014516-r59usk02 2228 19 or or CC cord-014516-r59usk02 2228 20 artifacts artifact NNS cord-014516-r59usk02 2228 21 ) ) -RRB- cord-014516-r59usk02 2228 22 and and CC cord-014516-r59usk02 2228 23 reported report VBD cord-014516-r59usk02 2228 24 to to IN cord-014516-r59usk02 2228 25 the the DT cord-014516-r59usk02 2228 26 degree degree NN cord-014516-r59usk02 2228 27 of of IN cord-014516-r59usk02 2228 28 atrial atrial JJ cord-014516-r59usk02 2228 29 remodeling remodeling NN cord-014516-r59usk02 2228 30 , , , cord-014516-r59usk02 2228 31 assessed assess VBN cord-014516-r59usk02 2228 32 by by IN cord-014516-r59usk02 2228 33 left leave VBN cord-014516-r59usk02 2228 34 atrium/ atrium/ NN cord-014516-r59usk02 2228 35 aorta aorta NN cord-014516-r59usk02 2228 36 ratio ratio NN cord-014516-r59usk02 2228 37 on on IN cord-014516-r59usk02 2228 38 echocardiography echocardiography NN cord-014516-r59usk02 2228 39 . . . cord-014516-r59usk02 2229 1 The the DT cord-014516-r59usk02 2229 2 interpretation interpretation NN cord-014516-r59usk02 2229 3 of of IN cord-014516-r59usk02 2229 4 the the DT cord-014516-r59usk02 2229 5 ECG ECG NNP cord-014516-r59usk02 2229 6 and and CC cord-014516-r59usk02 2229 7 echocardiography echocardiography NN cord-014516-r59usk02 2229 8 was be VBD cord-014516-r59usk02 2229 9 made make VBN cord-014516-r59usk02 2229 10 by by IN cord-014516-r59usk02 2229 11 the the DT cord-014516-r59usk02 2229 12 same same JJ cord-014516-r59usk02 2229 13 examiner examiner NN cord-014516-r59usk02 2229 14 ( ( -LRB- cord-014516-r59usk02 2229 15 MD MD NNP cord-014516-r59usk02 2229 16 ) ) -RRB- cord-014516-r59usk02 2229 17 . . . cord-014516-r59usk02 2230 1 The the DT cord-014516-r59usk02 2230 2 results result NNS cord-014516-r59usk02 2230 3 were be VBD cord-014516-r59usk02 2230 4 statistically statistically RB cord-014516-r59usk02 2230 5 evaluated evaluate VBN cord-014516-r59usk02 2230 6 in in IN cord-014516-r59usk02 2230 7 a a DT cord-014516-r59usk02 2230 8 specialized specialized JJ cord-014516-r59usk02 2230 9 program program NN cord-014516-r59usk02 2230 10 ( ( -LRB- cord-014516-r59usk02 2230 11 IBM IBM NNP cord-014516-r59usk02 2230 12 SPSS SPSS NNP cord-014516-r59usk02 2230 13 vs. vs. IN cord-014516-r59usk02 2230 14 21 21 CD cord-014516-r59usk02 2230 15 ) ) -RRB- cord-014516-r59usk02 2230 16 . . . cord-014516-r59usk02 2231 1 The the DT cord-014516-r59usk02 2231 2 P p NN cord-014516-r59usk02 2231 3 wave wave NN cord-014516-r59usk02 2231 4 recorded record VBN cord-014516-r59usk02 2231 5 average average JJ cord-014516-r59usk02 2231 6 values value NNS cord-014516-r59usk02 2231 7 was be VBD cord-014516-r59usk02 2231 8 0.061 0.061 CD cord-014516-r59usk02 2231 9 AE AE NNP cord-014516-r59usk02 2231 10 0.028 0.028 CD cord-014516-r59usk02 2231 11 seconds second NNS cord-014516-r59usk02 2231 12 for for IN cord-014516-r59usk02 2231 13 the the DT cord-014516-r59usk02 2231 14 MVD MVD NNP cord-014516-r59usk02 2231 15 group group NN cord-014516-r59usk02 2231 16 with with IN cord-014516-r59usk02 2231 17 significant significant JJ cord-014516-r59usk02 2231 18 differences difference NNS cord-014516-r59usk02 2231 19 between between IN cord-014516-r59usk02 2231 20 the the DT cord-014516-r59usk02 2231 21 stages stage NNS cord-014516-r59usk02 2231 22 of of IN cord-014516-r59usk02 2231 23 heart heart NN cord-014516-r59usk02 2231 24 failure failure NN cord-014516-r59usk02 2231 25 ( ( -LRB- cord-014516-r59usk02 2231 26 p p NN cord-014516-r59usk02 2231 27 = = SYM cord-014516-r59usk02 2231 28 0.008 0.008 CD cord-014516-r59usk02 2231 29 ) ) -RRB- cord-014516-r59usk02 2231 30 . . . cord-014516-r59usk02 2232 1 No no DT cord-014516-r59usk02 2232 2 correlations correlation NNS cord-014516-r59usk02 2232 3 were be VBD cord-014516-r59usk02 2232 4 found find VBN cord-014516-r59usk02 2232 5 between between IN cord-014516-r59usk02 2232 6 its -PRON- PRP$ cord-014516-r59usk02 2232 7 increase increase NN cord-014516-r59usk02 2232 8 and and CC cord-014516-r59usk02 2232 9 the the DT cord-014516-r59usk02 2232 10 dilation dilation NN cord-014516-r59usk02 2232 11 of of IN cord-014516-r59usk02 2232 12 the the DT cord-014516-r59usk02 2232 13 left left JJ cord-014516-r59usk02 2232 14 atrium atrium NN cord-014516-r59usk02 2233 1 ( ( -LRB- cord-014516-r59usk02 2233 2 R r NN cord-014516-r59usk02 2233 3 2 2 CD cord-014516-r59usk02 2233 4 = = SYM cord-014516-r59usk02 2233 5 0.012 0.012 CD cord-014516-r59usk02 2233 6 ) ) -RRB- cord-014516-r59usk02 2233 7 . . . cord-014516-r59usk02 2234 1 There there EX cord-014516-r59usk02 2234 2 was be VBD cord-014516-r59usk02 2234 3 no no DT cord-014516-r59usk02 2234 4 statistically statistically RB cord-014516-r59usk02 2234 5 significant significant JJ cord-014516-r59usk02 2234 6 difference difference NN cord-014516-r59usk02 2234 7 regarding regard VBG cord-014516-r59usk02 2234 8 P p NN cord-014516-r59usk02 2234 9 wave wave NN cord-014516-r59usk02 2234 10 duration duration NN cord-014516-r59usk02 2234 11 when when WRB cord-014516-r59usk02 2234 12 compared compare VBN cord-014516-r59usk02 2234 13 dogs dog NNS cord-014516-r59usk02 2234 14 of of IN cord-014516-r59usk02 2234 15 the the DT cord-014516-r59usk02 2234 16 neuropathy neuropathy NN cord-014516-r59usk02 2234 17 group group NN cord-014516-r59usk02 2234 18 and and CC cord-014516-r59usk02 2234 19 those those DT cord-014516-r59usk02 2234 20 of of IN cord-014516-r59usk02 2234 21 the the DT cord-014516-r59usk02 2234 22 mitral mitral JJ cord-014516-r59usk02 2234 23 valve valve NN cord-014516-r59usk02 2234 24 disease disease NN cord-014516-r59usk02 2234 25 group group NN cord-014516-r59usk02 2234 26 ( ( -LRB- cord-014516-r59usk02 2234 27 the the DT cord-014516-r59usk02 2234 28 P p NN cord-014516-r59usk02 2234 29 wave wave NN cord-014516-r59usk02 2234 30 recorded record VBN cord-014516-r59usk02 2234 31 average average JJ cord-014516-r59usk02 2234 32 values value NNS cord-014516-r59usk02 2234 33 = = SYM cord-014516-r59usk02 2234 34 0.068 0.068 CD cord-014516-r59usk02 2234 35 AE AE NNP cord-014516-r59usk02 2234 36 0.018 0.018 CD cord-014516-r59usk02 2234 37 sec sec NNP cord-014516-r59usk02 2234 38 . . . cord-014516-r59usk02 2234 39 ) ) -RRB- cord-014516-r59usk02 2234 40 . . . cord-014516-r59usk02 2235 1 Both both DT cord-014516-r59usk02 2235 2 , , , cord-014516-r59usk02 2235 3 atrial atrial JJ cord-014516-r59usk02 2235 4 tissue tissue NN cord-014516-r59usk02 2235 5 lesions lesion NNS cord-014516-r59usk02 2235 6 ( ( -LRB- cord-014516-r59usk02 2235 7 as as IN cord-014516-r59usk02 2235 8 in in IN cord-014516-r59usk02 2235 9 mitral mitral JJ cord-014516-r59usk02 2235 10 valve valve NN cord-014516-r59usk02 2235 11 disease disease NN cord-014516-r59usk02 2235 12 ) ) -RRB- cord-014516-r59usk02 2235 13 and and CC cord-014516-r59usk02 2235 14 autonomic autonomic JJ cord-014516-r59usk02 2235 15 nervous nervous JJ cord-014516-r59usk02 2235 16 system system NN cord-014516-r59usk02 2235 17 anomalies anomaly NNS cord-014516-r59usk02 2235 18 ( ( -LRB- cord-014516-r59usk02 2235 19 secondary secondary JJ cord-014516-r59usk02 2235 20 to to IN cord-014516-r59usk02 2235 21 a a DT cord-014516-r59usk02 2235 22 neurological neurological JJ cord-014516-r59usk02 2235 23 condition condition NN cord-014516-r59usk02 2235 24 ) ) -RRB- cord-014516-r59usk02 2235 25 , , , cord-014516-r59usk02 2235 26 may may MD cord-014516-r59usk02 2235 27 change change VB cord-014516-r59usk02 2235 28 the the DT cord-014516-r59usk02 2235 29 conductibility conductibility NN cord-014516-r59usk02 2235 30 of of IN cord-014516-r59usk02 2235 31 the the DT cord-014516-r59usk02 2235 32 electrical electrical JJ cord-014516-r59usk02 2235 33 impulse impulse NN cord-014516-r59usk02 2235 34 in in IN cord-014516-r59usk02 2235 35 the the DT cord-014516-r59usk02 2235 36 left left JJ cord-014516-r59usk02 2235 37 atrium atrium NN cord-014516-r59usk02 2235 38 . . . cord-014516-r59usk02 2236 1 The the DT cord-014516-r59usk02 2236 2 conductibility conductibility NN cord-014516-r59usk02 2236 3 of of IN cord-014516-r59usk02 2236 4 the the DT cord-014516-r59usk02 2236 5 electrical electrical JJ cord-014516-r59usk02 2236 6 impulse impulse NN cord-014516-r59usk02 2236 7 at at IN cord-014516-r59usk02 2236 8 this this DT cord-014516-r59usk02 2236 9 level level NN cord-014516-r59usk02 2236 10 does do VBZ cord-014516-r59usk02 2236 11 not not RB cord-014516-r59usk02 2236 12 seem seem VB cord-014516-r59usk02 2236 13 to to TO cord-014516-r59usk02 2236 14 be be VB cord-014516-r59usk02 2236 15 influenced influence VBN cord-014516-r59usk02 2236 16 by by IN cord-014516-r59usk02 2236 17 its -PRON- PRP$ cord-014516-r59usk02 2236 18 actual actual JJ cord-014516-r59usk02 2236 19 dilation dilation NN cord-014516-r59usk02 2236 20 , , , cord-014516-r59usk02 2236 21 but but CC cord-014516-r59usk02 2236 22 by by IN cord-014516-r59usk02 2236 23 the the DT cord-014516-r59usk02 2236 24 impairment impairment NN cord-014516-r59usk02 2236 25 of of IN cord-014516-r59usk02 2236 26 the the DT cord-014516-r59usk02 2236 27 intra intra JJ cord-014516-r59usk02 2236 28 - - JJ cord-014516-r59usk02 2236 29 atrial atrial JJ cord-014516-r59usk02 2236 30 and and CC cord-014516-r59usk02 2236 31 inter inter JJ cord-014516-r59usk02 2236 32 - - JJ cord-014516-r59usk02 2236 33 atrial atrial JJ cord-014516-r59usk02 2236 34 conduction conduction NN cord-014516-r59usk02 2236 35 pathways pathway NNS cord-014516-r59usk02 2236 36 . . . cord-014516-r59usk02 2237 1 Caution caution NN cord-014516-r59usk02 2237 2 must must MD cord-014516-r59usk02 2237 3 be be VB cord-014516-r59usk02 2237 4 given give VBN cord-014516-r59usk02 2237 5 when when WRB cord-014516-r59usk02 2237 6 P p NN cord-014516-r59usk02 2237 7 wave wave NN cord-014516-r59usk02 2237 8 is be VBZ cord-014516-r59usk02 2237 9 analyzed analyze VBN cord-014516-r59usk02 2237 10 in in IN cord-014516-r59usk02 2237 11 dogs dog NNS cord-014516-r59usk02 2237 12 with with IN cord-014516-r59usk02 2237 13 concurrent concurrent JJ cord-014516-r59usk02 2237 14 cardiologic cardiologic NN cord-014516-r59usk02 2237 15 and and CC cord-014516-r59usk02 2237 16 neurologic neurologic JJ cord-014516-r59usk02 2237 17 condition condition NN cord-014516-r59usk02 2237 18 . . . cord-014516-r59usk02 2238 1 No no DT cord-014516-r59usk02 2238 2 conflicts conflict NNS cord-014516-r59usk02 2238 3 of of IN cord-014516-r59usk02 2238 4 interest interest NN cord-014516-r59usk02 2238 5 reported report VBN cord-014516-r59usk02 2238 6 . . . cord-014516-r59usk02 2239 1 Newfoundland Newfoundland NNP cord-014516-r59usk02 2239 2 dogs dog NNS cord-014516-r59usk02 2239 3 were be VBD cord-014516-r59usk02 2239 4 prospectively prospectively RB cord-014516-r59usk02 2239 5 recruited recruit VBN cord-014516-r59usk02 2239 6 among among IN cord-014516-r59usk02 2239 7 those those DT cord-014516-r59usk02 2239 8 undergoing undergo VBG cord-014516-r59usk02 2239 9 screening screening NN cord-014516-r59usk02 2239 10 for for IN cord-014516-r59usk02 2239 11 congenital congenital JJ cord-014516-r59usk02 2239 12 and and CC cord-014516-r59usk02 2239 13 acquired acquire VBN cord-014516-r59usk02 2239 14 heart heart NN cord-014516-r59usk02 2239 15 disease disease NN cord-014516-r59usk02 2239 16 . . . cord-014516-r59usk02 2240 1 Screening screening NN cord-014516-r59usk02 2240 2 includes include VBZ cord-014516-r59usk02 2240 3 patient patient JJ cord-014516-r59usk02 2240 4 history history NN cord-014516-r59usk02 2240 5 , , , cord-014516-r59usk02 2240 6 physical physical JJ cord-014516-r59usk02 2240 7 examination examination NN cord-014516-r59usk02 2240 8 , , , cord-014516-r59usk02 2240 9 and and CC cord-014516-r59usk02 2240 10 systemic systemic JJ cord-014516-r59usk02 2240 11 arterial arterial JJ cord-014516-r59usk02 2240 12 pressure pressure NN cord-014516-r59usk02 2240 13 measurement measurement NN cord-014516-r59usk02 2240 14 by by IN cord-014516-r59usk02 2240 15 Doppler Doppler NNP cord-014516-r59usk02 2240 16 flow flow NN cord-014516-r59usk02 2240 17 meter meter NN cord-014516-r59usk02 2240 18 and and CC cord-014516-r59usk02 2240 19 transthoracic transthoracic NNP cord-014516-r59usk02 2240 20 echocardiography echocardiography NN cord-014516-r59usk02 2241 1 ( ( -LRB- cord-014516-r59usk02 2241 2 M M NNP cord-014516-r59usk02 2241 3 - - HYPH cord-014516-r59usk02 2241 4 mode mode NNP cord-014516-r59usk02 2241 5 , , , cord-014516-r59usk02 2241 6 2D 2d NN cord-014516-r59usk02 2241 7 and and CC cord-014516-r59usk02 2241 8 echo echo NN cord-014516-r59usk02 2241 9 - - HYPH cord-014516-r59usk02 2241 10 Doppler doppler NN cord-014516-r59usk02 2241 11 ) ) -RRB- cord-014516-r59usk02 2241 12 . . . cord-014516-r59usk02 2242 1 Screening screening NN cord-014516-r59usk02 2242 2 is be VBZ cord-014516-r59usk02 2242 3 performed perform VBN cord-014516-r59usk02 2242 4 on on IN cord-014516-r59usk02 2242 5 conscious conscious JJ cord-014516-r59usk02 2242 6 dogs dog NNS cord-014516-r59usk02 2242 7 of of IN cord-014516-r59usk02 2242 8 at at RB cord-014516-r59usk02 2242 9 least least RBS cord-014516-r59usk02 2242 10 1 1 CD cord-014516-r59usk02 2242 11 year year NN cord-014516-r59usk02 2242 12 of of IN cord-014516-r59usk02 2242 13 age age NN cord-014516-r59usk02 2242 14 . . . cord-014516-r59usk02 2243 1 Dogs dog NNS cord-014516-r59usk02 2243 2 without without IN cord-014516-r59usk02 2243 3 historical historical JJ cord-014516-r59usk02 2243 4 , , , cord-014516-r59usk02 2243 5 clinical clinical JJ cord-014516-r59usk02 2243 6 , , , cord-014516-r59usk02 2243 7 electrocardiographic electrocardiographic JJ cord-014516-r59usk02 2243 8 and and CC cord-014516-r59usk02 2243 9 echocardiographic echocardiographic JJ cord-014516-r59usk02 2243 10 signs sign NNS cord-014516-r59usk02 2243 11 of of IN cord-014516-r59usk02 2243 12 cardiovascular cardiovascular JJ cord-014516-r59usk02 2243 13 disease disease NN cord-014516-r59usk02 2243 14 were be VBD cord-014516-r59usk02 2243 15 included include VBN cord-014516-r59usk02 2243 16 in in IN cord-014516-r59usk02 2243 17 the the DT cord-014516-r59usk02 2243 18 study study NN cord-014516-r59usk02 2243 19 . . . cord-014516-r59usk02 2244 1 Unpaired Unpaired NNP cord-014516-r59usk02 2244 2 , , , cord-014516-r59usk02 2244 3 two two CD cord-014516-r59usk02 2244 4 - - HYPH cord-014516-r59usk02 2244 5 tailed tailed JJ cord-014516-r59usk02 2244 6 Student Student NNP cord-014516-r59usk02 2244 7 's 's POS cord-014516-r59usk02 2244 8 t t NN cord-014516-r59usk02 2244 9 - - HYPH cord-014516-r59usk02 2244 10 test test NN cord-014516-r59usk02 2244 11 and and CC cord-014516-r59usk02 2244 12 linear linear JJ cord-014516-r59usk02 2244 13 regression regression NN cord-014516-r59usk02 2244 14 were be VBD cord-014516-r59usk02 2244 15 performed perform VBN cord-014516-r59usk02 2244 16 to to TO cord-014516-r59usk02 2244 17 evaluate evaluate VB cord-014516-r59usk02 2244 18 the the DT cord-014516-r59usk02 2244 19 influence influence NN cord-014516-r59usk02 2244 20 of of IN cord-014516-r59usk02 2244 21 gender gender NN cord-014516-r59usk02 2244 22 , , , cord-014516-r59usk02 2244 23 age age NN cord-014516-r59usk02 2244 24 and and CC cord-014516-r59usk02 2244 25 body body NN cord-014516-r59usk02 2244 26 weight weight NN cord-014516-r59usk02 2244 27 ( ( -LRB- cord-014516-r59usk02 2244 28 BW BW NNP cord-014516-r59usk02 2244 29 ) ) -RRB- cord-014516-r59usk02 2244 30 on on IN cord-014516-r59usk02 2244 31 echocardiographic echocardiographic JJ cord-014516-r59usk02 2244 32 parameters parameter NNS cord-014516-r59usk02 2244 33 . . . cord-014516-r59usk02 2245 1 Echocardiographic echocardiographic JJ cord-014516-r59usk02 2245 2 measurements measurement NNS cord-014516-r59usk02 2245 3 were be VBD cord-014516-r59usk02 2245 4 compared compare VBN cord-014516-r59usk02 2245 5 to to IN cord-014516-r59usk02 2245 6 previously previously RB cord-014516-r59usk02 2245 7 reported report VBN cord-014516-r59usk02 2245 8 reference reference NN cord-014516-r59usk02 2245 9 values value NNS cord-014516-r59usk02 2245 10 . . . cord-014516-r59usk02 2246 1 The the DT cord-014516-r59usk02 2246 2 reference reference NN cord-014516-r59usk02 2246 3 limits limit NNS cord-014516-r59usk02 2246 4 of of IN cord-014516-r59usk02 2246 5 echocardiographic echocardiographic JJ cord-014516-r59usk02 2246 6 parameters parameter NNS cord-014516-r59usk02 2246 7 in in IN cord-014516-r59usk02 2246 8 the the DT cord-014516-r59usk02 2246 9 Newfoundland Newfoundland NNP cord-014516-r59usk02 2246 10 dogs dog NNS cord-014516-r59usk02 2246 11 were be VBD cord-014516-r59usk02 2246 12 calculated calculate VBN cord-014516-r59usk02 2246 13 . . . cord-014516-r59usk02 2247 1 Forty forty CD cord-014516-r59usk02 2247 2 - - HYPH cord-014516-r59usk02 2247 3 six six CD cord-014516-r59usk02 2247 4 healthy healthy JJ cord-014516-r59usk02 2247 5 adult adult NN cord-014516-r59usk02 2247 6 Newfoundland Newfoundland NNP cord-014516-r59usk02 2247 7 dogs dog NNS cord-014516-r59usk02 2247 8 of of IN cord-014516-r59usk02 2247 9 both both DT cord-014516-r59usk02 2247 10 genders gender NNS cord-014516-r59usk02 2247 11 ( ( -LRB- cord-014516-r59usk02 2247 12 20 20 CD cord-014516-r59usk02 2247 13 males male NNS cord-014516-r59usk02 2247 14 and and CC cord-014516-r59usk02 2247 15 26 26 CD cord-014516-r59usk02 2247 16 females female NNS cord-014516-r59usk02 2247 17 ) ) -RRB- cord-014516-r59usk02 2247 18 , , , cord-014516-r59usk02 2247 19 1 1 CD cord-014516-r59usk02 2247 20 to to TO cord-014516-r59usk02 2247 21 6 6 CD cord-014516-r59usk02 2247 22 years year NNS cord-014516-r59usk02 2247 23 of of IN cord-014516-r59usk02 2247 24 age age NN cord-014516-r59usk02 2247 25 ( ( -LRB- cord-014516-r59usk02 2247 26 mean mean VB cord-014516-r59usk02 2247 27 2.6 2.6 CD cord-014516-r59usk02 2247 28 AE AE NNP cord-014516-r59usk02 2247 29 1.6 1.6 CD cord-014516-r59usk02 2247 30 years year NNS cord-014516-r59usk02 2247 31 ) ) -RRB- cord-014516-r59usk02 2247 32 , , , cord-014516-r59usk02 2247 33 40 40 CD cord-014516-r59usk02 2247 34 to to TO cord-014516-r59usk02 2247 35 72 72 CD cord-014516-r59usk02 2247 36 kg kg NN cord-014516-r59usk02 2248 1 ( ( -LRB- cord-014516-r59usk02 2248 2 mean mean VB cord-014516-r59usk02 2248 3 54.7 54.7 CD cord-014516-r59usk02 2248 4 AE AE NNP cord-014516-r59usk02 2248 5 8.84 8.84 CD cord-014516-r59usk02 2248 6 kg kg NNS cord-014516-r59usk02 2248 7 ) ) -RRB- cord-014516-r59usk02 2248 8 fulfilled fulfil VBD cord-014516-r59usk02 2248 9 the the DT cord-014516-r59usk02 2248 10 inclusion inclusion NN cord-014516-r59usk02 2248 11 criteria criterion NNS cord-014516-r59usk02 2248 12 . . . cord-014516-r59usk02 2249 1 Significant significant JJ cord-014516-r59usk02 2249 2 but but CC cord-014516-r59usk02 2249 3 weak weak JJ cord-014516-r59usk02 2249 4 correlations correlation NNS cord-014516-r59usk02 2249 5 were be VBD cord-014516-r59usk02 2249 6 detected detect VBN cord-014516-r59usk02 2249 7 between between IN cord-014516-r59usk02 2249 8 aortic aortic JJ cord-014516-r59usk02 2249 9 diameter diameter NN cord-014516-r59usk02 2249 10 ( ( -LRB- cord-014516-r59usk02 2249 11 Ao Ao NNP cord-014516-r59usk02 2249 12 ) ) -RRB- cord-014516-r59usk02 2249 13 and and CC cord-014516-r59usk02 2249 14 age age NN cord-014516-r59usk02 2249 15 ( ( -LRB- cord-014516-r59usk02 2249 16 p p NN cord-014516-r59usk02 2249 17 = = SYM cord-014516-r59usk02 2249 18 0.012 0.012 CD cord-014516-r59usk02 2249 19 , , , cord-014516-r59usk02 2250 1 r r LS cord-014516-r59usk02 2250 2 2 2 CD cord-014516-r59usk02 2250 3 = = SYM cord-014516-r59usk02 2250 4 0.186 0.186 CD cord-014516-r59usk02 2250 5 ) ) -RRB- cord-014516-r59usk02 2250 6 , , , cord-014516-r59usk02 2250 7 left leave VBN cord-014516-r59usk02 2250 8 atrial atrial JJ cord-014516-r59usk02 2250 9 to to IN cord-014516-r59usk02 2250 10 aortic aortic JJ cord-014516-r59usk02 2250 11 ratio ratio NN cord-014516-r59usk02 2251 1 ( ( -LRB- cord-014516-r59usk02 2251 2 LA LA NNP cord-014516-r59usk02 2251 3 / / SYM cord-014516-r59usk02 2251 4 Ao Ao NNP cord-014516-r59usk02 2251 5 ) ) -RRB- cord-014516-r59usk02 2251 6 and and CC cord-014516-r59usk02 2251 7 age age NN cord-014516-r59usk02 2251 8 ( ( -LRB- cord-014516-r59usk02 2251 9 p p NN cord-014516-r59usk02 2251 10 = = SYM cord-014516-r59usk02 2251 11 0.047 0.047 CD cord-014516-r59usk02 2251 12 , , , cord-014516-r59usk02 2252 1 r r LS cord-014516-r59usk02 2252 2 2 2 CD cord-014516-r59usk02 2252 3 = = SYM cord-014516-r59usk02 2252 4 0.192 0.192 CD cord-014516-r59usk02 2252 5 ) ) -RRB- cord-014516-r59usk02 2252 6 , , , cord-014516-r59usk02 2252 7 E e NN cord-014516-r59usk02 2252 8 - - NN cord-014516-r59usk02 2252 9 point point NN cord-014516-r59usk02 2252 10 to to IN cord-014516-r59usk02 2252 11 septum septum NN cord-014516-r59usk02 2252 12 separation separation NN cord-014516-r59usk02 2252 13 ( ( -LRB- cord-014516-r59usk02 2252 14 EPSS EPSS NNP cord-014516-r59usk02 2252 15 ) ) -RRB- cord-014516-r59usk02 2252 16 and and CC cord-014516-r59usk02 2252 17 BW BW NNP cord-014516-r59usk02 2252 18 ( ( -LRB- cord-014516-r59usk02 2252 19 p p NN cord-014516-r59usk02 2252 20 = = SYM cord-014516-r59usk02 2252 21 0.038 0.038 CD cord-014516-r59usk02 2252 22 , , , cord-014516-r59usk02 2252 23 r r NN cord-014516-r59usk02 2252 24 2 2 CD cord-014516-r59usk02 2252 25 = = SYM cord-014516-r59usk02 2252 26 0.117 0.117 CD cord-014516-r59usk02 2252 27 ) ) -RRB- cord-014516-r59usk02 2253 1 , , , cord-014516-r59usk02 2253 2 M M NNP cord-014516-r59usk02 2253 3 - - HYPH cord-014516-r59usk02 2253 4 mode mode NN cord-014516-r59usk02 2253 5 left leave VBD cord-014516-r59usk02 2253 6 ventricular ventricular JJ cord-014516-r59usk02 2253 7 internal internal JJ cord-014516-r59usk02 2253 8 diameter diameter NN cord-014516-r59usk02 2253 9 ( ( -LRB- cord-014516-r59usk02 2253 10 LVID LVID NNP cord-014516-r59usk02 2253 11 ) ) -RRB- cord-014516-r59usk02 2253 12 in in IN cord-014516-r59usk02 2253 13 diastole diastole NNP cord-014516-r59usk02 2253 14 ( ( -LRB- cord-014516-r59usk02 2253 15 d d NN cord-014516-r59usk02 2253 16 ) ) -RRB- cord-014516-r59usk02 2253 17 and and CC cord-014516-r59usk02 2253 18 systole systole NNP cord-014516-r59usk02 2253 19 ( ( -LRB- cord-014516-r59usk02 2253 20 s s NN cord-014516-r59usk02 2253 21 ) ) -RRB- cord-014516-r59usk02 2253 22 and and CC cord-014516-r59usk02 2253 23 BW BW NNP cord-014516-r59usk02 2253 24 ( ( -LRB- cord-014516-r59usk02 2253 25 respectively respectively RB cord-014516-r59usk02 2253 26 p p NN cord-014516-r59usk02 2253 27 = = SYM cord-014516-r59usk02 2253 28 0.002 0.002 NN cord-014516-r59usk02 2253 29 , , , cord-014516-r59usk02 2253 30 r r NN cord-014516-r59usk02 2253 31 2 2 CD cord-014516-r59usk02 2253 32 = = SYM cord-014516-r59usk02 2253 33 0.201 0.201 CD cord-014516-r59usk02 2253 34 and and CC cord-014516-r59usk02 2253 35 p p NN cord-014516-r59usk02 2253 36 = = SYM cord-014516-r59usk02 2253 37 0.006 0.006 CD cord-014516-r59usk02 2253 38 , , , cord-014516-r59usk02 2253 39 r r NN cord-014516-r59usk02 2253 40 2 2 CD cord-014516-r59usk02 2253 41 = = SYM cord-014516-r59usk02 2253 42 0.158 0.158 CD cord-014516-r59usk02 2253 43 ) ) -RRB- cord-014516-r59usk02 2253 44 , , , cord-014516-r59usk02 2253 45 and and CC cord-014516-r59usk02 2253 46 between between IN cord-014516-r59usk02 2253 47 Ao Ao NNP cord-014516-r59usk02 2253 48 and and CC cord-014516-r59usk02 2253 49 BW BW NNP cord-014516-r59usk02 2253 50 ( ( -LRB- cord-014516-r59usk02 2253 51 p p NN cord-014516-r59usk02 2253 52 = = SYM cord-014516-r59usk02 2253 53 0.008 0.008 CD cord-014516-r59usk02 2253 54 , , , cord-014516-r59usk02 2253 55 r r NN cord-014516-r59usk02 2253 56 2 2 CD cord-014516-r59usk02 2253 57 = = SYM cord-014516-r59usk02 2253 58 0.203 0.203 CD cord-014516-r59usk02 2253 59 ) ) -RRB- cord-014516-r59usk02 2253 60 . . . cord-014516-r59usk02 2254 1 None none NN cord-014516-r59usk02 2254 2 of of IN cord-014516-r59usk02 2254 3 the the DT cord-014516-r59usk02 2254 4 echocardiographic echocardiographic JJ cord-014516-r59usk02 2254 5 measurements measurement NNS cord-014516-r59usk02 2254 6 was be VBD cord-014516-r59usk02 2254 7 statistically statistically RB cord-014516-r59usk02 2254 8 different different JJ cord-014516-r59usk02 2254 9 between between IN cord-014516-r59usk02 2254 10 males male NNS cord-014516-r59usk02 2254 11 and and CC cord-014516-r59usk02 2254 12 females female NNS cord-014516-r59usk02 2254 13 . . . cord-014516-r59usk02 2255 1 Left leave VBN cord-014516-r59usk02 2255 2 ventricular ventricular JJ cord-014516-r59usk02 2255 3 internal internal JJ cord-014516-r59usk02 2255 4 diameter diameter NN cord-014516-r59usk02 2255 5 in in IN cord-014516-r59usk02 2255 6 diastole diastole NN cord-014516-r59usk02 2255 7 , , , cord-014516-r59usk02 2255 8 LVIDs LVIDs NNP cord-014516-r59usk02 2255 9 , , , cord-014516-r59usk02 2255 10 Ao Ao NNP cord-014516-r59usk02 2255 11 , , , cord-014516-r59usk02 2255 12 EPSS EPSS NNP cord-014516-r59usk02 2255 13 increased increase VBD cord-014516-r59usk02 2255 14 with with IN cord-014516-r59usk02 2255 15 BW BW NNP cord-014516-r59usk02 2255 16 , , , cord-014516-r59usk02 2255 17 as as IN cord-014516-r59usk02 2255 18 expected expect VBN cord-014516-r59usk02 2255 19 . . . cord-014516-r59usk02 2256 1 The the DT cord-014516-r59usk02 2256 2 aorta aorta NN cord-014516-r59usk02 2256 3 appears appear VBZ cord-014516-r59usk02 2256 4 to to TO cord-014516-r59usk02 2256 5 become become VB cord-014516-r59usk02 2256 6 wider wide JJR cord-014516-r59usk02 2256 7 with with IN cord-014516-r59usk02 2256 8 advancing advance VBG cord-014516-r59usk02 2256 9 age age NN cord-014516-r59usk02 2256 10 . . . cord-014516-r59usk02 2257 1 A a DT cord-014516-r59usk02 2257 2 proportion proportion NN cord-014516-r59usk02 2257 3 of of IN cord-014516-r59usk02 2257 4 the the DT cord-014516-r59usk02 2257 5 studied study VBN cord-014516-r59usk02 2257 6 population population NN cord-014516-r59usk02 2257 7 had have VBD cord-014516-r59usk02 2257 8 M M NNP cord-014516-r59usk02 2257 9 - - HYPH cord-014516-r59usk02 2257 10 mode mode NN cord-014516-r59usk02 2257 11 parameters parameter NNS cord-014516-r59usk02 2257 12 below below IN cord-014516-r59usk02 2257 13 the the DT cord-014516-r59usk02 2257 14 allometric allometric JJ cord-014516-r59usk02 2257 15 scaling scale VBG cord-014516-r59usk02 2257 16 reference reference NN cord-014516-r59usk02 2257 17 range range NN cord-014516-r59usk02 2257 18 , , , cord-014516-r59usk02 2257 19 suggesting suggest VBG cord-014516-r59usk02 2257 20 that that IN cord-014516-r59usk02 2257 21 this this DT cord-014516-r59usk02 2257 22 method method NN cord-014516-r59usk02 2257 23 can can MD cord-014516-r59usk02 2257 24 over over IN cord-014516-r59usk02 2257 25 - - HYPH cord-014516-r59usk02 2257 26 estimates estimate NNS cord-014516-r59usk02 2257 27 M M NNP cord-014516-r59usk02 2257 28 - - HYPH cord-014516-r59usk02 2257 29 mode mode NN cord-014516-r59usk02 2257 30 parameters parameter NNS cord-014516-r59usk02 2257 31 in in IN cord-014516-r59usk02 2257 32 this this DT cord-014516-r59usk02 2257 33 breed breed NN cord-014516-r59usk02 2257 34 . . . cord-014516-r59usk02 2258 1 These these DT cord-014516-r59usk02 2258 2 findings finding NNS cord-014516-r59usk02 2258 3 stress stress VBP cord-014516-r59usk02 2258 4 the the DT cord-014516-r59usk02 2258 5 importance importance NN cord-014516-r59usk02 2258 6 to to TO cord-014516-r59usk02 2258 7 report report VB cord-014516-r59usk02 2258 8 Newfoundland Newfoundland NNP cord-014516-r59usk02 2258 9 breed breed VBP cord-014516-r59usk02 2258 10 specific specific JJ cord-014516-r59usk02 2258 11 normal normal JJ cord-014516-r59usk02 2258 12 ranges range NNS cord-014516-r59usk02 2258 13 for for IN cord-014516-r59usk02 2258 14 echocardiographic echocardiographic JJ cord-014516-r59usk02 2258 15 parameters parameter NNS cord-014516-r59usk02 2258 16 . . . cord-014516-r59usk02 2259 1 No no DT cord-014516-r59usk02 2259 2 conflicts conflict NNS cord-014516-r59usk02 2259 3 of of IN cord-014516-r59usk02 2259 4 interest interest NN cord-014516-r59usk02 2259 5 reported report VBN cord-014516-r59usk02 2259 6 . . . cord-014516-r59usk02 2260 1 Canine canine JJ cord-014516-r59usk02 2260 2 idiopathic idiopathic JJ cord-014516-r59usk02 2260 3 pulmonary pulmonary JJ cord-014516-r59usk02 2260 4 fibrosis fibrosis NN cord-014516-r59usk02 2260 5 ( ( -LRB- cord-014516-r59usk02 2260 6 CIPF CIPF NNP cord-014516-r59usk02 2260 7 ) ) -RRB- cord-014516-r59usk02 2260 8 is be VBZ cord-014516-r59usk02 2260 9 a a DT cord-014516-r59usk02 2260 10 progressive progressive JJ cord-014516-r59usk02 2260 11 interstitial interstitial JJ cord-014516-r59usk02 2260 12 lung lung NN cord-014516-r59usk02 2260 13 disease disease NN cord-014516-r59usk02 2260 14 usually usually RB cord-014516-r59usk02 2260 15 diagnosed diagnose VBN cord-014516-r59usk02 2260 16 by by IN cord-014516-r59usk02 2260 17 thoracic thoracic JJ cord-014516-r59usk02 2260 18 CT CT NNP cord-014516-r59usk02 2260 19 - - NN cord-014516-r59usk02 2260 20 scan scan NNP cord-014516-r59usk02 2260 21 that that WDT cord-014516-r59usk02 2260 22 mainly mainly RB cord-014516-r59usk02 2260 23 affects affect VBZ cord-014516-r59usk02 2260 24 West West NNP cord-014516-r59usk02 2260 25 Highland Highland NNP cord-014516-r59usk02 2260 26 white white JJ cord-014516-r59usk02 2260 27 terriers terrier NNS cord-014516-r59usk02 2260 28 ( ( -LRB- cord-014516-r59usk02 2260 29 WHWT WHWT NNP cord-014516-r59usk02 2260 30 ) ) -RRB- cord-014516-r59usk02 2260 31 . . . cord-014516-r59usk02 2261 1 Pulmonary pulmonary JJ cord-014516-r59usk02 2261 2 hypertension hypertension NN cord-014516-r59usk02 2261 3 ( ( -LRB- cord-014516-r59usk02 2261 4 PH PH NNP cord-014516-r59usk02 2261 5 ) ) -RRB- cord-014516-r59usk02 2261 6 , , , cord-014516-r59usk02 2261 7 a a DT cord-014516-r59usk02 2261 8 severe severe JJ cord-014516-r59usk02 2261 9 co co JJ cord-014516-r59usk02 2261 10 - - JJ cord-014516-r59usk02 2261 11 morbid morbid JJ cord-014516-r59usk02 2261 12 condition condition NN cord-014516-r59usk02 2261 13 with with IN cord-014516-r59usk02 2261 14 a a DT cord-014516-r59usk02 2261 15 challenging challenging JJ cord-014516-r59usk02 2261 16 diagnosis diagnosis NN cord-014516-r59usk02 2261 17 , , , cord-014516-r59usk02 2261 18 may may MD cord-014516-r59usk02 2261 19 develop develop VB cord-014516-r59usk02 2261 20 in in IN cord-014516-r59usk02 2261 21 CIPF CIPF NNP cord-014516-r59usk02 2261 22 dogs dog NNS cord-014516-r59usk02 2261 23 . . . cord-014516-r59usk02 2262 1 The the DT cord-014516-r59usk02 2262 2 ratio ratio NN cord-014516-r59usk02 2262 3 between between IN cord-014516-r59usk02 2262 4 the the DT cord-014516-r59usk02 2262 5 right right JJ cord-014516-r59usk02 2262 6 pulmonary pulmonary JJ cord-014516-r59usk02 2262 7 vein vein NN cord-014516-r59usk02 2262 8 and and CC cord-014516-r59usk02 2262 9 pulmonary pulmonary JJ cord-014516-r59usk02 2262 10 artery artery NN cord-014516-r59usk02 2262 11 ( ( -LRB- cord-014516-r59usk02 2263 1 PV/ PV/ NNP cord-014516-r59usk02 2263 2 PA PA NNP cord-014516-r59usk02 2263 3 ) ) -RRB- cord-014516-r59usk02 2263 4 has have VBZ cord-014516-r59usk02 2263 5 been be VBN cord-014516-r59usk02 2263 6 described describe VBN cord-014516-r59usk02 2263 7 as as IN cord-014516-r59usk02 2263 8 an an DT cord-014516-r59usk02 2263 9 echocardiographic echocardiographic JJ cord-014516-r59usk02 2263 10 indicator indicator NN cord-014516-r59usk02 2263 11 of of IN cord-014516-r59usk02 2263 12 PH PH NNP cord-014516-r59usk02 2263 13 in in IN cord-014516-r59usk02 2263 14 CIPFdogs CIPFdogs NNP cord-014516-r59usk02 2263 15 . . . cord-014516-r59usk02 2264 1 This this DT cord-014516-r59usk02 2264 2 study study NN cord-014516-r59usk02 2264 3 was be VBD cord-014516-r59usk02 2264 4 intended intend VBN cord-014516-r59usk02 2264 5 to to TO cord-014516-r59usk02 2264 6 investigate investigate VB cord-014516-r59usk02 2264 7 whether whether IN cord-014516-r59usk02 2264 8 CT CT NNP cord-014516-r59usk02 2264 9 - - HYPH cord-014516-r59usk02 2264 10 scan scan JJ cord-014516-r59usk02 2264 11 angiography angiography NN cord-014516-r59usk02 2264 12 cardiac cardiac JJ cord-014516-r59usk02 2264 13 findings finding NNS cord-014516-r59usk02 2264 14 are be VBP cord-014516-r59usk02 2264 15 1 1 CD cord-014516-r59usk02 2264 16 ) ) -RRB- cord-014516-r59usk02 2264 17 altered alter VBN cord-014516-r59usk02 2264 18 in in IN cord-014516-r59usk02 2264 19 dogs dog NNS cord-014516-r59usk02 2264 20 with with IN cord-014516-r59usk02 2264 21 cIPF cipf NN cord-014516-r59usk02 2264 22 compared compare VBN cord-014516-r59usk02 2264 23 to to IN cord-014516-r59usk02 2264 24 healthy healthy JJ cord-014516-r59usk02 2264 25 control control NN cord-014516-r59usk02 2264 26 dogs dog NNS cord-014516-r59usk02 2264 27 and and CC cord-014516-r59usk02 2264 28 2 2 CD cord-014516-r59usk02 2264 29 ) ) -RRB- cord-014516-r59usk02 2264 30 correlated correlate VBN cord-014516-r59usk02 2264 31 with with IN cord-014516-r59usk02 2264 32 PV PV NNP cord-014516-r59usk02 2264 33 / / SYM cord-014516-r59usk02 2264 34 PA PA NNP cord-014516-r59usk02 2264 35 measured measure VBN cord-014516-r59usk02 2264 36 by by IN cord-014516-r59usk02 2264 37 echocardiography echocardiography NN cord-014516-r59usk02 2264 38 ( ( -LRB- cord-014516-r59usk02 2264 39 PV PV NNP cord-014516-r59usk02 2264 40 / / SYM cord-014516-r59usk02 2264 41 PA PA NNP cord-014516-r59usk02 2264 42 US US NNP cord-014516-r59usk02 2264 43 ) ) -RRB- cord-014516-r59usk02 2264 44 . . . cord-014516-r59usk02 2265 1 Thoracic thoracic JJ cord-014516-r59usk02 2265 2 CTA CTA NNP cord-014516-r59usk02 2265 3 images image NNS cord-014516-r59usk02 2265 4 from from IN cord-014516-r59usk02 2265 5 6 6 CD cord-014516-r59usk02 2265 6 WHWT WHWT NNS cord-014516-r59usk02 2265 7 with with IN cord-014516-r59usk02 2265 8 CIPF CIPF NNP cord-014516-r59usk02 2265 9 ( ( -LRB- cord-014516-r59usk02 2265 10 Group Group NNP cord-014516-r59usk02 2265 11 A A NNP cord-014516-r59usk02 2265 12 ) ) -RRB- cord-014516-r59usk02 2265 13 and and CC cord-014516-r59usk02 2266 1 9 9 CD cord-014516-r59usk02 2266 2 healthy healthy JJ cord-014516-r59usk02 2266 3 controls control NNS cord-014516-r59usk02 2266 4 from from IN cord-014516-r59usk02 2266 5 various various JJ cord-014516-r59usk02 2266 6 breeds breed NNS cord-014516-r59usk02 2266 7 ( ( -LRB- cord-014516-r59usk02 2266 8 Group Group NNP cord-014516-r59usk02 2266 9 B B NNP cord-014516-r59usk02 2266 10 ) ) -RRB- cord-014516-r59usk02 2266 11 were be VBD cord-014516-r59usk02 2266 12 retrospectively retrospectively RB cord-014516-r59usk02 2266 13 reviewed review VBN cord-014516-r59usk02 2266 14 by by IN cord-014516-r59usk02 2266 15 one one CD cord-014516-r59usk02 2266 16 observer observer NN cord-014516-r59usk02 2266 17 . . . cord-014516-r59usk02 2267 1 All all DT cord-014516-r59usk02 2267 2 measurements measurement NNS cord-014516-r59usk02 2267 3 were be VBD cord-014516-r59usk02 2267 4 obtained obtain VBN cord-014516-r59usk02 2267 5 in in IN cord-014516-r59usk02 2267 6 transverse transverse JJ cord-014516-r59usk02 2267 7 post post JJ cord-014516-r59usk02 2267 8 - - JJ cord-014516-r59usk02 2267 9 contrast contrast JJ cord-014516-r59usk02 2267 10 images image NNS cord-014516-r59usk02 2267 11 displayed display VBN cord-014516-r59usk02 2267 12 in in IN cord-014516-r59usk02 2267 13 a a DT cord-014516-r59usk02 2267 14 soft soft JJ cord-014516-r59usk02 2267 15 tissue tissue NN cord-014516-r59usk02 2267 16 window window NN cord-014516-r59usk02 2267 17 . . . cord-014516-r59usk02 2268 1 PV PV NNP cord-014516-r59usk02 2268 2 and and CC cord-014516-r59usk02 2268 3 PA PA NNP cord-014516-r59usk02 2268 4 were be VBD cord-014516-r59usk02 2268 5 measured measure VBN cord-014516-r59usk02 2268 6 dorsal dorsal RB cord-014516-r59usk02 2268 7 to to IN cord-014516-r59usk02 2268 8 the the DT cord-014516-r59usk02 2268 9 right right JJ cord-014516-r59usk02 2268 10 atrium atrium NN cord-014516-r59usk02 2268 11 , , , cord-014516-r59usk02 2268 12 perpendicular perpendicular JJ cord-014516-r59usk02 2268 13 to to IN cord-014516-r59usk02 2268 14 the the DT cord-014516-r59usk02 2268 15 long long JJ cord-014516-r59usk02 2268 16 axis axis NN cord-014516-r59usk02 2268 17 of of IN cord-014516-r59usk02 2268 18 these these DT cord-014516-r59usk02 2268 19 vessels vessel NNS cord-014516-r59usk02 2268 20 . . . cord-014516-r59usk02 2269 1 In in IN cord-014516-r59usk02 2269 2 addition addition NN cord-014516-r59usk02 2269 3 , , , cord-014516-r59usk02 2269 4 pulmonary pulmonary JJ cord-014516-r59usk02 2269 5 trunk trunk NN cord-014516-r59usk02 2269 6 ( ( -LRB- cord-014516-r59usk02 2269 7 PT pt NN cord-014516-r59usk02 2269 8 ) ) -RRB- cord-014516-r59usk02 2269 9 was be VBD cord-014516-r59usk02 2269 10 assessed assess VBN cord-014516-r59usk02 2269 11 just just RB cord-014516-r59usk02 2269 12 ventral ventral JJ cord-014516-r59usk02 2269 13 to to IN cord-014516-r59usk02 2269 14 the the DT cord-014516-r59usk02 2269 15 division division NN cord-014516-r59usk02 2269 16 of of IN cord-014516-r59usk02 2269 17 pulmonary pulmonary JJ cord-014516-r59usk02 2269 18 arteries artery NNS cord-014516-r59usk02 2269 19 , , , cord-014516-r59usk02 2269 20 perpendicular perpendicular JJ cord-014516-r59usk02 2269 21 to to IN cord-014516-r59usk02 2269 22 its -PRON- PRP$ cord-014516-r59usk02 2269 23 long long JJ cord-014516-r59usk02 2269 24 axis axis NN cord-014516-r59usk02 2269 25 . . . cord-014516-r59usk02 2270 1 Ascending ascend VBG cord-014516-r59usk02 2270 2 aorta aorta NN cord-014516-r59usk02 2270 3 ( ( -LRB- cord-014516-r59usk02 2270 4 Ao Ao NNP cord-014516-r59usk02 2270 5 ) ) -RRB- cord-014516-r59usk02 2270 6 was be VBD cord-014516-r59usk02 2270 7 also also RB cord-014516-r59usk02 2270 8 measured measure VBN cord-014516-r59usk02 2270 9 perpendicular perpendicular RB cord-014516-r59usk02 2270 10 to to IN cord-014516-r59usk02 2270 11 its -PRON- PRP$ cord-014516-r59usk02 2270 12 long long JJ cord-014516-r59usk02 2270 13 axis axis NN cord-014516-r59usk02 2270 14 . . . cord-014516-r59usk02 2271 1 Transverse transverse JJ cord-014516-r59usk02 2271 2 reformatted reformatte VBN cord-014516-r59usk02 2271 3 images image NNS cord-014516-r59usk02 2271 4 were be VBD cord-014516-r59usk02 2271 5 obtained obtain VBN cord-014516-r59usk02 2271 6 to to TO cord-014516-r59usk02 2271 7 have have VB cord-014516-r59usk02 2271 8 a a DT cord-014516-r59usk02 2271 9 view view NN cord-014516-r59usk02 2271 10 equivalent equivalent JJ cord-014516-r59usk02 2271 11 to to IN cord-014516-r59usk02 2271 12 the the DT cord-014516-r59usk02 2271 13 standard standard JJ cord-014516-r59usk02 2271 14 4 4 CD cord-014516-r59usk02 2271 15 chambers chamber NNS cord-014516-r59usk02 2271 16 - - HYPH cord-014516-r59usk02 2271 17 echocardiographic echocardiographic JJ cord-014516-r59usk02 2271 18 view view NN cord-014516-r59usk02 2271 19 where where WRB cord-014516-r59usk02 2271 20 right right JJ cord-014516-r59usk02 2271 21 ventricle ventricle NN cord-014516-r59usk02 2271 22 ( ( -LRB- cord-014516-r59usk02 2271 23 RV RV NNP cord-014516-r59usk02 2271 24 ) ) -RRB- cord-014516-r59usk02 2271 25 and and CC cord-014516-r59usk02 2271 26 left left JJ cord-014516-r59usk02 2271 27 ventricle ventricle NN cord-014516-r59usk02 2271 28 ( ( -LRB- cord-014516-r59usk02 2271 29 LV LV NNP cord-014516-r59usk02 2271 30 ) ) -RRB- cord-014516-r59usk02 2271 31 were be VBD cord-014516-r59usk02 2271 32 measured measure VBN cord-014516-r59usk02 2271 33 . . . cord-014516-r59usk02 2272 1 Three three CD cord-014516-r59usk02 2272 2 ratios ratio NNS cord-014516-r59usk02 2272 3 were be VBD cord-014516-r59usk02 2272 4 calculated calculate VBN cord-014516-r59usk02 2272 5 PV PV NNP cord-014516-r59usk02 2272 6 / / SYM cord-014516-r59usk02 2272 7 PA PA NNP cord-014516-r59usk02 2272 8 CT CT NNP cord-014516-r59usk02 2272 9 , , , cord-014516-r59usk02 2272 10 PT PT NNP cord-014516-r59usk02 2272 11 / / SYM cord-014516-r59usk02 2272 12 Ao Ao NNP cord-014516-r59usk02 2272 13 and and CC cord-014516-r59usk02 2272 14 RV RV NNP cord-014516-r59usk02 2272 15 / / SYM cord-014516-r59usk02 2272 16 LV LV NNP cord-014516-r59usk02 2272 17 , , , cord-014516-r59usk02 2272 18 compared compare VBN cord-014516-r59usk02 2272 19 between between IN cord-014516-r59usk02 2272 20 groups group NNS cord-014516-r59usk02 2272 21 and and CC cord-014516-r59usk02 2272 22 correlated correlate VBN cord-014516-r59usk02 2272 23 with with IN cord-014516-r59usk02 2272 24 PV PV NNP cord-014516-r59usk02 2272 25 / / SYM cord-014516-r59usk02 2272 26 PA PA NNP cord-014516-r59usk02 2272 27 US US NNP cord-014516-r59usk02 2272 28 in in IN cord-014516-r59usk02 2272 29 both both DT cord-014516-r59usk02 2272 30 bi bi JJ cord-014516-r59usk02 2272 31 - - JJ cord-014516-r59usk02 2272 32 dimensional dimensional JJ cord-014516-r59usk02 2272 33 ( ( -LRB- cord-014516-r59usk02 2272 34 BD BD NNP cord-014516-r59usk02 2272 35 ) ) -RRB- cord-014516-r59usk02 2272 36 and and CC cord-014516-r59usk02 2272 37 M M NNP cord-014516-r59usk02 2272 38 - - HYPH cord-014516-r59usk02 2272 39 modes modes NNP cord-014516-r59usk02 2272 40 ( ( -LRB- cord-014516-r59usk02 2272 41 MM MM NNP cord-014516-r59usk02 2272 42 ) ) -RRB- cord-014516-r59usk02 2272 43 . . . cord-014516-r59usk02 2273 1 Statistical statistical JJ cord-014516-r59usk02 2273 2 analyses analysis NNS cord-014516-r59usk02 2273 3 were be VBD cord-014516-r59usk02 2273 4 performed perform VBN cord-014516-r59usk02 2273 5 with with IN cord-014516-r59usk02 2273 6 XLStat XLStat NNP cord-014516-r59usk02 2273 7 â â NN cord-014516-r59usk02 2273 8 software software NN cord-014516-r59usk02 2273 9 . . . cord-014516-r59usk02 2274 1 Values value NNS cord-014516-r59usk02 2274 2 are be VBP cord-014516-r59usk02 2274 3 given give VBN cord-014516-r59usk02 2274 4 as as IN cord-014516-r59usk02 2274 5 mean mean JJ cord-014516-r59usk02 2274 6 AE AE NNP cord-014516-r59usk02 2274 7 sd sd NNP cord-014516-r59usk02 2274 8 . . . cord-014516-r59usk02 2275 1 Statistical statistical JJ cord-014516-r59usk02 2275 2 significance significance NN cord-014516-r59usk02 2275 3 was be VBD cord-014516-r59usk02 2275 4 set set VBN cord-014516-r59usk02 2275 5 at at IN cord-014516-r59usk02 2275 6 a a DT cord-014516-r59usk02 2275 7 P p NN cord-014516-r59usk02 2275 8 ≤ ≤ NN cord-014516-r59usk02 2275 9 0.05 0.05 CD cord-014516-r59usk02 2275 10 . . . cord-014516-r59usk02 2276 1 PV PV NNP cord-014516-r59usk02 2276 2 / / SYM cord-014516-r59usk02 2276 3 PA PA NNP cord-014516-r59usk02 2276 4 CT CT NNP cord-014516-r59usk02 2276 5 was be VBD cord-014516-r59usk02 2276 6 lower low JJR cord-014516-r59usk02 2276 7 in in IN cord-014516-r59usk02 2276 8 group group NN cord-014516-r59usk02 2276 9 A a NN cord-014516-r59usk02 2276 10 ( ( -LRB- cord-014516-r59usk02 2276 11 0.64 0.64 CD cord-014516-r59usk02 2276 12 AE AE NNP cord-014516-r59usk02 2276 13 0.18 0.18 CD cord-014516-r59usk02 2276 14 ) ) -RRB- cord-014516-r59usk02 2276 15 in in IN cord-014516-r59usk02 2276 16 comparison comparison NN cord-014516-r59usk02 2276 17 to to IN cord-014516-r59usk02 2276 18 group group NN cord-014516-r59usk02 2276 19 B B NNP cord-014516-r59usk02 2276 20 ( ( -LRB- cord-014516-r59usk02 2276 21 1.00 1.00 CD cord-014516-r59usk02 2276 22 AE AE NNP cord-014516-r59usk02 2276 23 0.23 0.23 CD cord-014516-r59usk02 2276 24 , , , cord-014516-r59usk02 2276 25 P p NN cord-014516-r59usk02 2276 26 = = SYM cord-014516-r59usk02 2276 27 0.008 0.008 CD cord-014516-r59usk02 2276 28 ) ) -RRB- cord-014516-r59usk02 2276 29 and and CC cord-014516-r59usk02 2276 30 correlated correlate VBN cord-014516-r59usk02 2276 31 with with IN cord-014516-r59usk02 2276 32 PV PV NNP cord-014516-r59usk02 2276 33 / / SYM cord-014516-r59usk02 2276 34 PA PA NNP cord-014516-r59usk02 2276 35 US US NNP cord-014516-r59usk02 2276 36 ( ( -LRB- cord-014516-r59usk02 2276 37 BD BD NNP cord-014516-r59usk02 2276 38 : : : cord-014516-r59usk02 2276 39 r r NN cord-014516-r59usk02 2276 40 = = SYM cord-014516-r59usk02 2276 41 0.796 0.796 CD cord-014516-r59usk02 2276 42 , , , cord-014516-r59usk02 2276 43 P p NN cord-014516-r59usk02 2276 44 = = SYM cord-014516-r59usk02 2276 45 0.001 0.001 CD cord-014516-r59usk02 2276 46 ; ; : cord-014516-r59usk02 2276 47 MM mm NN cord-014516-r59usk02 2276 48 : : : cord-014516-r59usk02 2277 1 r r LS cord-014516-r59usk02 2278 1 = = SYM cord-014516-r59usk02 2278 2 0.730 0.730 CD cord-014516-r59usk02 2278 3 , , , cord-014516-r59usk02 2278 4 P p NN cord-014516-r59usk02 2278 5 = = SYM cord-014516-r59usk02 2278 6 0.003 0.003 CD cord-014516-r59usk02 2278 7 ) ) -RRB- cord-014516-r59usk02 2278 8 . . . cord-014516-r59usk02 2279 1 PT PT NNP cord-014516-r59usk02 2279 2 / / SYM cord-014516-r59usk02 2279 3 Ao Ao NNP cord-014516-r59usk02 2279 4 was be VBD cord-014516-r59usk02 2279 5 higher high JJR cord-014516-r59usk02 2279 6 in in IN cord-014516-r59usk02 2279 7 group group NN cord-014516-r59usk02 2279 8 A a NN cord-014516-r59usk02 2279 9 ( ( -LRB- cord-014516-r59usk02 2279 10 1.18 1.18 CD cord-014516-r59usk02 2279 11 AE AE NNP cord-014516-r59usk02 2279 12 0.08 0.08 CD cord-014516-r59usk02 2279 13 ) ) -RRB- cord-014516-r59usk02 2279 14 compared compare VBN cord-014516-r59usk02 2279 15 to to IN cord-014516-r59usk02 2279 16 group group NN cord-014516-r59usk02 2279 17 B B NNP cord-014516-r59usk02 2279 18 ( ( -LRB- cord-014516-r59usk02 2279 19 0.92 0.92 CD cord-014516-r59usk02 2279 20 AE AE NNP cord-014516-r59usk02 2279 21 0.14 0.14 CD cord-014516-r59usk02 2279 22 , , , cord-014516-r59usk02 2279 23 P p NN cord-014516-r59usk02 2279 24 = = SYM cord-014516-r59usk02 2279 25 0.001 0.001 CD cord-014516-r59usk02 2279 26 ) ) -RRB- cord-014516-r59usk02 2279 27 and and CC cord-014516-r59usk02 2279 28 correlated correlate VBN cord-014516-r59usk02 2279 29 only only RB cord-014516-r59usk02 2279 30 with with IN cord-014516-r59usk02 2279 31 PV PV NNP cord-014516-r59usk02 2279 32 / / SYM cord-014516-r59usk02 2279 33 PA PA NNP cord-014516-r59usk02 2279 34 US US NNP cord-014516-r59usk02 2279 35 measured measure VBD cord-014516-r59usk02 2279 36 in in IN cord-014516-r59usk02 2279 37 BD BD NNP cord-014516-r59usk02 2279 38 mode mode NN cord-014516-r59usk02 2280 1 ( ( -LRB- cord-014516-r59usk02 2280 2 r r NN cord-014516-r59usk02 2280 3 = = SYM cord-014516-r59usk02 2280 4 -0.623 -0.623 NNP cord-014516-r59usk02 2280 5 , , , cord-014516-r59usk02 2280 6 P p NN cord-014516-r59usk02 2280 7 = = SYM cord-014516-r59usk02 2280 8 0.02 0.02 CD cord-014516-r59usk02 2280 9 ) ) -RRB- cord-014516-r59usk02 2280 10 . . . cord-014516-r59usk02 2281 1 The the DT cord-014516-r59usk02 2281 2 RV RV NNP cord-014516-r59usk02 2281 3 / / SYM cord-014516-r59usk02 2281 4 LV LV NNP cord-014516-r59usk02 2281 5 ratio ratio NN cord-014516-r59usk02 2281 6 was be VBD cord-014516-r59usk02 2281 7 increased increase VBN cord-014516-r59usk02 2281 8 in in IN cord-014516-r59usk02 2281 9 group group NN cord-014516-r59usk02 2281 10 A a NN cord-014516-r59usk02 2281 11 ( ( -LRB- cord-014516-r59usk02 2281 12 0.91 0.91 CD cord-014516-r59usk02 2281 13 AE AE NNP cord-014516-r59usk02 2281 14 0.11 0.11 CD cord-014516-r59usk02 2281 15 ) ) -RRB- cord-014516-r59usk02 2281 16 in in IN cord-014516-r59usk02 2281 17 comparison comparison NN cord-014516-r59usk02 2281 18 to to IN cord-014516-r59usk02 2281 19 group group NN cord-014516-r59usk02 2281 20 B B NNP cord-014516-r59usk02 2281 21 ( ( -LRB- cord-014516-r59usk02 2281 22 0.70 0.70 CD cord-014516-r59usk02 2281 23 AE AE NNP cord-014516-r59usk02 2281 24 0.08 0.08 CD cord-014516-r59usk02 2281 25 , , , cord-014516-r59usk02 2281 26 P p NN cord-014516-r59usk02 2281 27 = = SYM cord-014516-r59usk02 2281 28 0.001 0.001 CD cord-014516-r59usk02 2281 29 ) ) -RRB- cord-014516-r59usk02 2281 30 and and CC cord-014516-r59usk02 2281 31 a a DT cord-014516-r59usk02 2281 32 correlation correlation NN cord-014516-r59usk02 2281 33 between between IN cord-014516-r59usk02 2281 34 RV RV NNP cord-014516-r59usk02 2281 35 / / SYM cord-014516-r59usk02 2281 36 LV LV NNP cord-014516-r59usk02 2281 37 and and CC cord-014516-r59usk02 2281 38 PV PV NNP cord-014516-r59usk02 2281 39 / / SYM cord-014516-r59usk02 2281 40 PA PA NNP cord-014516-r59usk02 2281 41 US US NNP cord-014516-r59usk02 2281 42 was be VBD cord-014516-r59usk02 2281 43 found find VBN cord-014516-r59usk02 2281 44 ( ( -LRB- cord-014516-r59usk02 2281 45 BD bd NN cord-014516-r59usk02 2281 46 : : : cord-014516-r59usk02 2282 1 r r LS cord-014516-r59usk02 2282 2 = = SYM cord-014516-r59usk02 2282 3 -0.726 -0.726 NNP cord-014516-r59usk02 2282 4 , , , cord-014516-r59usk02 2282 5 P p NN cord-014516-r59usk02 2282 6 = = SYM cord-014516-r59usk02 2282 7 0.005 0.005 CD cord-014516-r59usk02 2282 8 ; ; : cord-014516-r59usk02 2282 9 MM mm NN cord-014516-r59usk02 2282 10 : : : cord-014516-r59usk02 2283 1 r r LS cord-014516-r59usk02 2283 2 = = NFP cord-014516-r59usk02 2284 1 -0.657 -0.657 . cord-014516-r59usk02 2285 1 , , , cord-014516-r59usk02 2285 2 P p NN cord-014516-r59usk02 2285 3 = = SYM cord-014516-r59usk02 2285 4 0.01 0.01 CD cord-014516-r59usk02 2285 5 ) ) -RRB- cord-014516-r59usk02 2285 6 . . . cord-014516-r59usk02 2286 1 In in IN cord-014516-r59usk02 2286 2 conclusion conclusion NN cord-014516-r59usk02 2286 3 , , , cord-014516-r59usk02 2286 4 in in IN cord-014516-r59usk02 2286 5 WHWT whwt NN cord-014516-r59usk02 2286 6 with with IN cord-014516-r59usk02 2286 7 CIPF CIPF NNP cord-014516-r59usk02 2286 8 , , , cord-014516-r59usk02 2286 9 PV PV NNP cord-014516-r59usk02 2286 10 / / SYM cord-014516-r59usk02 2286 11 PA PA NNP cord-014516-r59usk02 2286 12 CT CT NNP cord-014516-r59usk02 2286 13 , , , cord-014516-r59usk02 2286 14 PT PT NNP cord-014516-r59usk02 2286 15 / / SYM cord-014516-r59usk02 2286 16 Ao Ao NNP cord-014516-r59usk02 2286 17 and and CC cord-014516-r59usk02 2286 18 RV RV NNP cord-014516-r59usk02 2286 19 / / SYM cord-014516-r59usk02 2286 20 LV LV NNP cord-014516-r59usk02 2286 21 ratios ratio NNS cord-014516-r59usk02 2286 22 measured measure VBN cord-014516-r59usk02 2286 23 on on IN cord-014516-r59usk02 2286 24 thoracic thoracic JJ cord-014516-r59usk02 2286 25 CTA CTA NNP cord-014516-r59usk02 2286 26 images image NNS cord-014516-r59usk02 2286 27 are be VBP cord-014516-r59usk02 2286 28 correlated correlate VBN cord-014516-r59usk02 2286 29 with with IN cord-014516-r59usk02 2286 30 PV PV NNP cord-014516-r59usk02 2286 31 / / SYM cord-014516-r59usk02 2286 32 PA PA NNP cord-014516-r59usk02 2286 33 US US NNP cord-014516-r59usk02 2286 34 and and CC cord-014516-r59usk02 2286 35 may may MD cord-014516-r59usk02 2286 36 serve serve VB cord-014516-r59usk02 2286 37 in in IN cord-014516-r59usk02 2286 38 the the DT cord-014516-r59usk02 2286 39 assessment assessment NN cord-014516-r59usk02 2286 40 of of IN cord-014516-r59usk02 2286 41 PH PH NNP cord-014516-r59usk02 2286 42 . . . cord-014516-r59usk02 2287 1 No no DT cord-014516-r59usk02 2287 2 conflicts conflict NNS cord-014516-r59usk02 2287 3 of of IN cord-014516-r59usk02 2287 4 interest interest NN cord-014516-r59usk02 2287 5 reported report VBN cord-014516-r59usk02 2287 6 . . . cord-014516-r59usk02 2288 1 Companion companion NN cord-014516-r59usk02 2288 2 animals animal NNS cord-014516-r59usk02 2288 3 presenting present VBG cord-014516-r59usk02 2288 4 to to IN cord-014516-r59usk02 2288 5 the the DT cord-014516-r59usk02 2288 6 emergency emergency NN cord-014516-r59usk02 2288 7 room room NN cord-014516-r59usk02 2288 8 in in IN cord-014516-r59usk02 2288 9 distress distress NN cord-014516-r59usk02 2288 10 need need NN cord-014516-r59usk02 2288 11 to to TO cord-014516-r59usk02 2288 12 be be VB cord-014516-r59usk02 2288 13 assessed assess VBN cord-014516-r59usk02 2288 14 rapidly rapidly RB cord-014516-r59usk02 2288 15 and and CC cord-014516-r59usk02 2288 16 accurately accurately RB cord-014516-r59usk02 2288 17 to to TO cord-014516-r59usk02 2288 18 implement implement VB cord-014516-r59usk02 2288 19 life life NN cord-014516-r59usk02 2288 20 - - HYPH cord-014516-r59usk02 2288 21 saving save VBG cord-014516-r59usk02 2288 22 therapies therapy NNS cord-014516-r59usk02 2288 23 . . . cord-014516-r59usk02 2289 1 Focused focus VBN cord-014516-r59usk02 2289 2 cardiac cardiac JJ cord-014516-r59usk02 2289 3 ultrasound ultrasound NN cord-014516-r59usk02 2289 4 ( ( -LRB- cord-014516-r59usk02 2289 5 FOCUS FOCUS NNP cord-014516-r59usk02 2289 6 ) ) -RRB- cord-014516-r59usk02 2289 7 can can MD cord-014516-r59usk02 2289 8 be be VB cord-014516-r59usk02 2289 9 a a DT cord-014516-r59usk02 2289 10 useful useful JJ cord-014516-r59usk02 2289 11 adjunct adjunct NN cord-014516-r59usk02 2289 12 to to IN cord-014516-r59usk02 2289 13 the the DT cord-014516-r59usk02 2289 14 physical physical JJ cord-014516-r59usk02 2289 15 examination examination NN cord-014516-r59usk02 2289 16 in in IN cord-014516-r59usk02 2289 17 assessing assess VBG cord-014516-r59usk02 2289 18 dyspneic dyspneic JJ cord-014516-r59usk02 2289 19 animals animal NNS cord-014516-r59usk02 2289 20 in in IN cord-014516-r59usk02 2289 21 the the DT cord-014516-r59usk02 2289 22 emergency emergency NN cord-014516-r59usk02 2289 23 room room NN cord-014516-r59usk02 2289 24 . . . cord-014516-r59usk02 2290 1 Rapid rapid JJ cord-014516-r59usk02 2290 2 bedside bedside NN cord-014516-r59usk02 2290 3 ultrasound ultrasound NN cord-014516-r59usk02 2290 4 evaluations evaluation NNS cord-014516-r59usk02 2290 5 performed perform VBN cord-014516-r59usk02 2290 6 by by IN cord-014516-r59usk02 2290 7 EC EC NNP cord-014516-r59usk02 2290 8 are be VBP cord-014516-r59usk02 2290 9 commonly commonly RB cord-014516-r59usk02 2290 10 used use VBN cord-014516-r59usk02 2290 11 in in IN cord-014516-r59usk02 2290 12 human human JJ cord-014516-r59usk02 2290 13 medicine medicine NN cord-014516-r59usk02 2290 14 , , , cord-014516-r59usk02 2290 15 however however RB cord-014516-r59usk02 2290 16 feasibility feasibility NN cord-014516-r59usk02 2290 17 and and CC cord-014516-r59usk02 2290 18 utility utility NN cord-014516-r59usk02 2290 19 of of IN cord-014516-r59usk02 2290 20 FOCUS focus NN cord-014516-r59usk02 2290 21 by by IN cord-014516-r59usk02 2290 22 EC EC NNP cord-014516-r59usk02 2290 23 in in IN cord-014516-r59usk02 2290 24 veterinary veterinary JJ cord-014516-r59usk02 2290 25 medicine medicine NN cord-014516-r59usk02 2290 26 has have VBZ cord-014516-r59usk02 2290 27 not not RB cord-014516-r59usk02 2290 28 been be VBN cord-014516-r59usk02 2290 29 fully fully RB cord-014516-r59usk02 2290 30 evaluated evaluate VBN cord-014516-r59usk02 2290 31 . . . cord-014516-r59usk02 2291 1 The the DT cord-014516-r59usk02 2291 2 purpose purpose NN cord-014516-r59usk02 2291 3 of of IN cord-014516-r59usk02 2291 4 this this DT cord-014516-r59usk02 2291 5 study study NN cord-014516-r59usk02 2291 6 is be VBZ cord-014516-r59usk02 2291 7 to to TO cord-014516-r59usk02 2291 8 determine determine VB cord-014516-r59usk02 2291 9 the the DT cord-014516-r59usk02 2291 10 baseline baseline JJ cord-014516-r59usk02 2291 11 accuracy accuracy NN cord-014516-r59usk02 2291 12 of of IN cord-014516-r59usk02 2291 13 FOCUS FOCUS NNP cord-014516-r59usk02 2291 14 performed perform VBN cord-014516-r59usk02 2291 15 by by IN cord-014516-r59usk02 2291 16 EC EC NNP cord-014516-r59usk02 2291 17 and and CC cord-014516-r59usk02 2291 18 whether whether IN cord-014516-r59usk02 2291 19 or or CC cord-014516-r59usk02 2291 20 not not RB cord-014516-r59usk02 2291 21 a a DT cord-014516-r59usk02 2291 22 basic basic JJ cord-014516-r59usk02 2291 23 training training NN cord-014516-r59usk02 2291 24 session session NN cord-014516-r59usk02 2291 25 could could MD cord-014516-r59usk02 2291 26 improve improve VB cord-014516-r59usk02 2291 27 accuracy accuracy NN cord-014516-r59usk02 2291 28 compared compare VBN cord-014516-r59usk02 2291 29 to to IN cord-014516-r59usk02 2291 30 evaluation evaluation NN cord-014516-r59usk02 2291 31 by by IN cord-014516-r59usk02 2291 32 a a DT cord-014516-r59usk02 2291 33 cardiology cardiology NN cord-014516-r59usk02 2291 34 specialist specialist NN cord-014516-r59usk02 2291 35 . . . cord-014516-r59usk02 2292 1 Fifteen fifteen CD cord-014516-r59usk02 2292 2 EC EC NNP cord-014516-r59usk02 2292 3 including include VBG cord-014516-r59usk02 2292 4 6 6 CD cord-014516-r59usk02 2292 5 boarded board VBN cord-014516-r59usk02 2292 6 emergency emergency NN cord-014516-r59usk02 2292 7 - - HYPH cord-014516-r59usk02 2292 8 critical critical JJ cord-014516-r59usk02 2292 9 care care NN cord-014516-r59usk02 2292 10 specialists specialist NNS cord-014516-r59usk02 2292 11 and and CC cord-014516-r59usk02 2292 12 9 9 CD cord-014516-r59usk02 2292 13 emergency emergency NN cord-014516-r59usk02 2292 14 res re NNS cord-014516-r59usk02 2292 15 - - HYPH cord-014516-r59usk02 2292 16 idents ident NNS cord-014516-r59usk02 2292 17 performed perform VBD cord-014516-r59usk02 2292 18 FOCUS FOCUS NNP cord-014516-r59usk02 2292 19 on on IN cord-014516-r59usk02 2292 20 four four CD cord-014516-r59usk02 2292 21 animals animal NNS cord-014516-r59usk02 2292 22 ; ; : cord-014516-r59usk02 2292 23 a a DT cord-014516-r59usk02 2292 24 normal normal JJ cord-014516-r59usk02 2292 25 cat cat NN cord-014516-r59usk02 2292 26 and and CC cord-014516-r59usk02 2292 27 dog dog NN cord-014516-r59usk02 2292 28 , , , cord-014516-r59usk02 2292 29 and and CC cord-014516-r59usk02 2292 30 a a DT cord-014516-r59usk02 2292 31 cat cat NN cord-014516-r59usk02 2292 32 and and CC cord-014516-r59usk02 2292 33 dog dog NN cord-014516-r59usk02 2292 34 with with IN cord-014516-r59usk02 2292 35 severe severe JJ cord-014516-r59usk02 2292 36 valvular valvular JJ cord-014516-r59usk02 2292 37 and and CC cord-014516-r59usk02 2292 38 myocardial myocardial JJ cord-014516-r59usk02 2292 39 heart heart NN cord-014516-r59usk02 2292 40 disease disease NN cord-014516-r59usk02 2292 41 , , , cord-014516-r59usk02 2292 42 respectively respectively RB cord-014516-r59usk02 2292 43 . . . cord-014516-r59usk02 2293 1 EC EC NNP cord-014516-r59usk02 2293 2 semi semi RB cord-014516-r59usk02 2293 3 - - RB cord-014516-r59usk02 2293 4 quantitatively quantitatively RB cord-014516-r59usk02 2293 5 assessed assess VBN cord-014516-r59usk02 2293 6 6 6 CD cord-014516-r59usk02 2293 7 thoracic thoracic JJ cord-014516-r59usk02 2293 8 and and CC cord-014516-r59usk02 2293 9 echocardiographic echocardiographic JJ cord-014516-r59usk02 2293 10 parameters parameter NNS cord-014516-r59usk02 2293 11 including include VBG cord-014516-r59usk02 2293 12 left left JJ cord-014516-r59usk02 2293 13 atrial atrial JJ cord-014516-r59usk02 2293 14 dimension dimension NN cord-014516-r59usk02 2293 15 , , , cord-014516-r59usk02 2293 16 left leave VBN cord-014516-r59usk02 2293 17 ventricular ventricular JJ cord-014516-r59usk02 2293 18 systolic systolic JJ cord-014516-r59usk02 2293 19 function function NN cord-014516-r59usk02 2293 20 and and CC cord-014516-r59usk02 2293 21 wall wall NN cord-014516-r59usk02 2293 22 thickness thickness NN cord-014516-r59usk02 2293 23 , , , cord-014516-r59usk02 2293 24 right right JJ cord-014516-r59usk02 2293 25 heart heart NN cord-014516-r59usk02 2293 26 dimension dimension NN cord-014516-r59usk02 2293 27 , , , cord-014516-r59usk02 2293 28 and and CC cord-014516-r59usk02 2293 29 presence presence NN cord-014516-r59usk02 2293 30 or or CC cord-014516-r59usk02 2293 31 absence absence NN cord-014516-r59usk02 2293 32 of of IN cord-014516-r59usk02 2293 33 pleural pleural JJ cord-014516-r59usk02 2293 34 or or CC cord-014516-r59usk02 2293 35 pericardial pericardial JJ cord-014516-r59usk02 2293 36 effusion effusion NN cord-014516-r59usk02 2293 37 before before IN cord-014516-r59usk02 2293 38 and and CC cord-014516-r59usk02 2293 39 after after IN cord-014516-r59usk02 2293 40 a a DT cord-014516-r59usk02 2293 41 structured structured JJ cord-014516-r59usk02 2293 42 didactic didactic JJ cord-014516-r59usk02 2293 43 lecture lecture NN cord-014516-r59usk02 2293 44 and and CC cord-014516-r59usk02 2293 45 hands hand NNS cord-014516-r59usk02 2293 46 - - HYPH cord-014516-r59usk02 2293 47 on on RP cord-014516-r59usk02 2293 48 practical practical JJ cord-014516-r59usk02 2293 49 session session NN cord-014516-r59usk02 2293 50 . . . cord-014516-r59usk02 2294 1 Primary primary JJ cord-014516-r59usk02 2294 2 outcome outcome NN cord-014516-r59usk02 2294 3 was be VBD cord-014516-r59usk02 2294 4 the the DT cord-014516-r59usk02 2294 5 level level NN cord-014516-r59usk02 2294 6 of of IN cord-014516-r59usk02 2294 7 agreement agreement NN cord-014516-r59usk02 2294 8 with with IN cord-014516-r59usk02 2294 9 examination examination NN cord-014516-r59usk02 2294 10 performed perform VBN cord-014516-r59usk02 2294 11 by by IN cord-014516-r59usk02 2294 12 a a DT cord-014516-r59usk02 2294 13 cardiologist cardiologist NN cord-014516-r59usk02 2294 14 . . . cord-014516-r59usk02 2295 1 Level level NN cord-014516-r59usk02 2295 2 of of IN cord-014516-r59usk02 2295 3 agreement agreement NN cord-014516-r59usk02 2295 4 regarding regard VBG cord-014516-r59usk02 2295 5 EC EC NNP cord-014516-r59usk02 2295 6 assessment assessment NN cord-014516-r59usk02 2295 7 of of IN cord-014516-r59usk02 2295 8 all all DT cord-014516-r59usk02 2295 9 parameters parameter NNS cord-014516-r59usk02 2295 10 improved improve VBD cord-014516-r59usk02 2295 11 from from IN cord-014516-r59usk02 2295 12 0.70 0.70 CD cord-014516-r59usk02 2295 13 to to IN cord-014516-r59usk02 2295 14 0.78 0.78 CD cord-014516-r59usk02 2295 15 after after IN cord-014516-r59usk02 2295 16 training training NN cord-014516-r59usk02 2295 17 ( ( -LRB- cord-014516-r59usk02 2295 18 P p NN cord-014516-r59usk02 2295 19 < < XX cord-014516-r59usk02 2295 20 0.01 0.01 CD cord-014516-r59usk02 2295 21 ) ) -RRB- cord-014516-r59usk02 2295 22 . . . cord-014516-r59usk02 2296 1 Level level NN cord-014516-r59usk02 2296 2 of of IN cord-014516-r59usk02 2296 3 agreement agreement NN cord-014516-r59usk02 2296 4 concerning concern VBG cord-014516-r59usk02 2296 5 left leave VBN cord-014516-r59usk02 2296 6 atrial atrial JJ cord-014516-r59usk02 2296 7 diameter diameter NN cord-014516-r59usk02 2296 8 improved improve VBN cord-014516-r59usk02 2296 9 from from IN cord-014516-r59usk02 2296 10 0.52 0.52 CD cord-014516-r59usk02 2296 11 to to IN cord-014516-r59usk02 2296 12 0.75 0.75 CD cord-014516-r59usk02 2296 13 ( ( -LRB- cord-014516-r59usk02 2296 14 P p NN cord-014516-r59usk02 2296 15 < < XX cord-014516-r59usk02 2296 16 0.01 0.01 CD cord-014516-r59usk02 2296 17 ) ) -RRB- cord-014516-r59usk02 2296 18 . . . cord-014516-r59usk02 2297 1 EC EC NNP cord-014516-r59usk02 2297 2 confidence confidence NN cord-014516-r59usk02 2297 3 in in IN cord-014516-r59usk02 2297 4 their -PRON- PRP$ cord-014516-r59usk02 2297 5 overall overall JJ cord-014516-r59usk02 2297 6 FOCUS FOCUS NNP cord-014516-r59usk02 2297 7 evaluation evaluation NN cord-014516-r59usk02 2297 8 and and CC cord-014516-r59usk02 2297 9 findings finding NNS cord-014516-r59usk02 2297 10 improved improve VBD cord-014516-r59usk02 2297 11 from from IN cord-014516-r59usk02 2297 12 51 51 CD cord-014516-r59usk02 2297 13 % % NN cord-014516-r59usk02 2297 14 to to TO cord-014516-r59usk02 2297 15 70 70 CD cord-014516-r59usk02 2297 16 % % NN cord-014516-r59usk02 2297 17 ( ( -LRB- cord-014516-r59usk02 2297 18 P p NN cord-014516-r59usk02 2297 19 < < XX cord-014516-r59usk02 2297 20 0.0001 0.0001 CD cord-014516-r59usk02 2297 21 ) ) -RRB- cord-014516-r59usk02 2297 22 . . . cord-014516-r59usk02 2298 1 In in IN cord-014516-r59usk02 2298 2 summary summary NN cord-014516-r59usk02 2298 3 , , , cord-014516-r59usk02 2298 4 EC EC NNP cord-014516-r59usk02 2298 5 accuracy accuracy NN cord-014516-r59usk02 2298 6 and and CC cord-014516-r59usk02 2298 7 confidence confidence NN cord-014516-r59usk02 2298 8 in in IN cord-014516-r59usk02 2298 9 semi semi RB cord-014516-r59usk02 2298 10 - - JJ cord-014516-r59usk02 2298 11 quantitatively quantitatively RB cord-014516-r59usk02 2298 12 assessing assess VBG cord-014516-r59usk02 2298 13 basic basic JJ cord-014516-r59usk02 2298 14 cardiac cardiac JJ cord-014516-r59usk02 2298 15 parameters parameter NNS cord-014516-r59usk02 2298 16 using use VBG cord-014516-r59usk02 2298 17 FOCUS FOCUS NNP cord-014516-r59usk02 2298 18 were be VBD cord-014516-r59usk02 2298 19 improved improve VBN cord-014516-r59usk02 2298 20 following follow VBG cord-014516-r59usk02 2298 21 a a DT cord-014516-r59usk02 2298 22 simple simple JJ cord-014516-r59usk02 2298 23 structured structured JJ cord-014516-r59usk02 2298 24 training training NN cord-014516-r59usk02 2298 25 session session NN cord-014516-r59usk02 2298 26 . . . cord-014516-r59usk02 2299 1 FOCUS FOCUS NNP cord-014516-r59usk02 2299 2 might may MD cord-014516-r59usk02 2299 3 be be VB cord-014516-r59usk02 2299 4 a a DT cord-014516-r59usk02 2299 5 valuable valuable JJ cord-014516-r59usk02 2299 6 tool tool NN cord-014516-r59usk02 2299 7 to to TO cord-014516-r59usk02 2299 8 rapidly rapidly RB cord-014516-r59usk02 2299 9 assess assess VB cord-014516-r59usk02 2299 10 simple simple JJ cord-014516-r59usk02 2299 11 thoracic thoracic JJ cord-014516-r59usk02 2299 12 and and CC cord-014516-r59usk02 2299 13 cardiac cardiac JJ cord-014516-r59usk02 2299 14 parameters parameter NNS cord-014516-r59usk02 2299 15 in in IN cord-014516-r59usk02 2299 16 the the DT cord-014516-r59usk02 2299 17 emergency emergency NN cord-014516-r59usk02 2299 18 setting setting NN cord-014516-r59usk02 2299 19 . . . cord-014516-r59usk02 2300 1 No no DT cord-014516-r59usk02 2300 2 conflicts conflict NNS cord-014516-r59usk02 2300 3 of of IN cord-014516-r59usk02 2300 4 interest interest NN cord-014516-r59usk02 2300 5 reported report VBN cord-014516-r59usk02 2300 6 . . . cord-014516-r59usk02 2301 1 Obesity obesity NN cord-014516-r59usk02 2301 2 is be VBZ cord-014516-r59usk02 2301 3 an an DT cord-014516-r59usk02 2301 4 increasing increase VBG cord-014516-r59usk02 2301 5 health health NN cord-014516-r59usk02 2301 6 problem problem NN cord-014516-r59usk02 2301 7 in in IN cord-014516-r59usk02 2301 8 dogs dog NNS cord-014516-r59usk02 2301 9 . . . cord-014516-r59usk02 2302 1 Success success NN cord-014516-r59usk02 2302 2 of of IN cord-014516-r59usk02 2302 3 weight weight NN cord-014516-r59usk02 2302 4 - - HYPH cord-014516-r59usk02 2302 5 loss loss NN cord-014516-r59usk02 2302 6 programs program NNS cord-014516-r59usk02 2302 7 is be VBZ cord-014516-r59usk02 2302 8 often often RB cord-014516-r59usk02 2302 9 limited limit VBN cord-014516-r59usk02 2302 10 by by IN cord-014516-r59usk02 2302 11 compliance compliance NN cord-014516-r59usk02 2302 12 issues issue NNS cord-014516-r59usk02 2302 13 . . . cord-014516-r59usk02 2303 1 The the DT cord-014516-r59usk02 2303 2 purpose purpose NN cord-014516-r59usk02 2303 3 of of IN cord-014516-r59usk02 2303 4 this this DT cord-014516-r59usk02 2303 5 study study NN cord-014516-r59usk02 2303 6 was be VBD cord-014516-r59usk02 2303 7 to to TO cord-014516-r59usk02 2303 8 determine determine VB cord-014516-r59usk02 2303 9 the the DT cord-014516-r59usk02 2303 10 effectiveness effectiveness NN cord-014516-r59usk02 2303 11 of of IN cord-014516-r59usk02 2303 12 a a DT cord-014516-r59usk02 2303 13 new new JJ cord-014516-r59usk02 2303 14 dietetic dietetic JJ cord-014516-r59usk02 2303 15 weight weight NN cord-014516-r59usk02 2303 16 management management NN cord-014516-r59usk02 2303 17 food food NN cord-014516-r59usk02 2303 18 ( ( -LRB- cord-014516-r59usk02 2303 19 NDWMF NDWMF NNP cord-014516-r59usk02 2303 20 ) ) -RRB- cord-014516-r59usk02 2303 21 * * NFP cord-014516-r59usk02 2303 22 in in IN cord-014516-r59usk02 2303 23 achieving achieve VBG cord-014516-r59usk02 2303 24 weight weight NN cord-014516-r59usk02 2303 25 loss loss NN cord-014516-r59usk02 2303 26 in in IN cord-014516-r59usk02 2303 27 overweight overweight NN cord-014516-r59usk02 2303 28 / / SYM cord-014516-r59usk02 2303 29 obese obese JJ cord-014516-r59usk02 2303 30 , , , cord-014516-r59usk02 2303 31 client client NN cord-014516-r59usk02 2303 32 - - HYPH cord-014516-r59usk02 2303 33 owned own VBN cord-014516-r59usk02 2303 34 dogs dog NNS cord-014516-r59usk02 2303 35 , , , cord-014516-r59usk02 2303 36 under under IN cord-014516-r59usk02 2303 37 typical typical JJ cord-014516-r59usk02 2303 38 household household NN cord-014516-r59usk02 2303 39 conditions condition NNS cord-014516-r59usk02 2303 40 . . . cord-014516-r59usk02 2304 1 The the DT cord-014516-r59usk02 2304 2 objectives objective NNS cord-014516-r59usk02 2304 3 were be VBD cord-014516-r59usk02 2304 4 1 1 CD cord-014516-r59usk02 2304 5 ) ) -RRB- cord-014516-r59usk02 2304 6 to to TO cord-014516-r59usk02 2304 7 evaluate evaluate VB cord-014516-r59usk02 2304 8 weight weight NN cord-014516-r59usk02 2304 9 loss loss NN cord-014516-r59usk02 2304 10 parameters parameter NNS cord-014516-r59usk02 2304 11 in in IN cord-014516-r59usk02 2304 12 dogs dog NNS cord-014516-r59usk02 2304 13 fed feed VBD cord-014516-r59usk02 2304 14 a a DT cord-014516-r59usk02 2304 15 NDWMF NDWMF NNP cord-014516-r59usk02 2304 16 * * NFP cord-014516-r59usk02 2304 17 and and CC cord-014516-r59usk02 2304 18 2 2 LS cord-014516-r59usk02 2304 19 ) ) -RRB- cord-014516-r59usk02 2304 20 to to TO cord-014516-r59usk02 2304 21 assess assess VB cord-014516-r59usk02 2304 22 the the DT cord-014516-r59usk02 2304 23 owner owner NN cord-014516-r59usk02 2304 24 's 's POS cord-014516-r59usk02 2304 25 perception perception NN cord-014516-r59usk02 2304 26 of of IN cord-014516-r59usk02 2304 27 the the DT cord-014516-r59usk02 2304 28 dog dog NN cord-014516-r59usk02 2304 29 's 's POS cord-014516-r59usk02 2304 30 quality quality NN cord-014516-r59usk02 2304 31 of of IN cord-014516-r59usk02 2304 32 life life NN cord-014516-r59usk02 2304 33 . . . cord-014516-r59usk02 2305 1 Overweight overweight JJ cord-014516-r59usk02 2305 2 / / SYM cord-014516-r59usk02 2305 3 obese obese JJ cord-014516-r59usk02 2305 4 , , , cord-014516-r59usk02 2305 5 otherwise otherwise RB cord-014516-r59usk02 2305 6 healthy healthy JJ cord-014516-r59usk02 2305 7 , , , cord-014516-r59usk02 2305 8 client client NN cord-014516-r59usk02 2305 9 - - HYPH cord-014516-r59usk02 2305 10 owned own VBN cord-014516-r59usk02 2305 11 dogs dog NNS cord-014516-r59usk02 2305 12 ( ( -LRB- cord-014516-r59usk02 2305 13 > > NFP cord-014516-r59usk02 2305 14 3/5 3/5 CD cord-014516-r59usk02 2305 15 body body NN cord-014516-r59usk02 2305 16 condition condition NN cord-014516-r59usk02 2305 17 score score NN cord-014516-r59usk02 2305 18 -BCS -bcs ADD cord-014516-r59usk02 2305 19 ) ) -RRB- cord-014516-r59usk02 2305 20 were be VBD cord-014516-r59usk02 2305 21 enrolled enrol VBN cord-014516-r59usk02 2305 22 in in IN cord-014516-r59usk02 2305 23 the the DT cord-014516-r59usk02 2305 24 study study NN cord-014516-r59usk02 2305 25 ( ( -LRB- cord-014516-r59usk02 2305 26 n n NN cord-014516-r59usk02 2305 27 = = SYM cord-014516-r59usk02 2305 28 162 162 CD cord-014516-r59usk02 2305 29 ) ) -RRB- cord-014516-r59usk02 2305 30 . . . cord-014516-r59usk02 2306 1 Initial initial JJ cord-014516-r59usk02 2306 2 veterinary veterinary JJ cord-014516-r59usk02 2306 3 evaluation evaluation NN cord-014516-r59usk02 2306 4 included include VBD cord-014516-r59usk02 2306 5 physical physical JJ cord-014516-r59usk02 2306 6 examination examination NN cord-014516-r59usk02 2306 7 , , , cord-014516-r59usk02 2306 8 nutritional nutritional JJ cord-014516-r59usk02 2306 9 assessment assessment NN cord-014516-r59usk02 2306 10 , , , cord-014516-r59usk02 2306 11 determination determination NN cord-014516-r59usk02 2306 12 of of IN cord-014516-r59usk02 2306 13 ideal ideal JJ cord-014516-r59usk02 2306 14 body body NN cord-014516-r59usk02 2306 15 weight weight NN cord-014516-r59usk02 2306 16 ( ( -LRB- cord-014516-r59usk02 2306 17 IBW IBW NNP cord-014516-r59usk02 2306 18 ) ) -RRB- cord-014516-r59usk02 2306 19 , , , cord-014516-r59usk02 2306 20 and and CC cord-014516-r59usk02 2306 21 development development NN cord-014516-r59usk02 2306 22 of of IN cord-014516-r59usk02 2306 23 weightloss weightloss JJ cord-014516-r59usk02 2306 24 feeding feeding NN cord-014516-r59usk02 2306 25 guidelines guideline NNS cord-014516-r59usk02 2306 26 . . . cord-014516-r59usk02 2307 1 Daily daily JJ cord-014516-r59usk02 2307 2 energy energy NN cord-014516-r59usk02 2307 3 requirement requirement NN cord-014516-r59usk02 2307 4 ( ( -LRB- cord-014516-r59usk02 2307 5 DER DER NNP cord-014516-r59usk02 2307 6 ) ) -RRB- cord-014516-r59usk02 2307 7 for for IN cord-014516-r59usk02 2307 8 weight weight NN cord-014516-r59usk02 2307 9 loss loss NN cord-014516-r59usk02 2307 10 was be VBD cord-014516-r59usk02 2307 11 calculated calculate VBN cord-014516-r59usk02 2307 12 as as IN cord-014516-r59usk02 2307 13 DER DER NNP cord-014516-r59usk02 2307 14 = = SYM cord-014516-r59usk02 2307 15 70 70 CD cord-014516-r59usk02 2307 16 x x SYM cord-014516-r59usk02 2307 17 IBW IBW NNP cord-014516-r59usk02 2307 18 kg kg NNP cord-014516-r59usk02 2307 19 0.75 0.75 CD cord-014516-r59usk02 2307 20 . . . cord-014516-r59usk02 2308 1 Initial initial JJ cord-014516-r59usk02 2308 2 and and CC cord-014516-r59usk02 2308 3 follow follow VB cord-014516-r59usk02 2308 4 - - HYPH cord-014516-r59usk02 2308 5 up up RP cord-014516-r59usk02 2308 6 evaluations evaluation NNS cord-014516-r59usk02 2308 7 ( ( -LRB- cord-014516-r59usk02 2308 8 monthly monthly JJ cord-014516-r59usk02 2308 9 for for IN cord-014516-r59usk02 2308 10 6 6 CD cord-014516-r59usk02 2308 11 months month NNS cord-014516-r59usk02 2308 12 ) ) -RRB- cord-014516-r59usk02 2308 13 encompassed encompass VBD cord-014516-r59usk02 2308 14 determination determination NN cord-014516-r59usk02 2308 15 of of IN cord-014516-r59usk02 2308 16 body body NN cord-014516-r59usk02 2308 17 weight weight NN cord-014516-r59usk02 2308 18 , , , cord-014516-r59usk02 2308 19 BCS BCS NNP cord-014516-r59usk02 2308 20 , , , cord-014516-r59usk02 2308 21 body body NN cord-014516-r59usk02 2308 22 fat fat NN cord-014516-r59usk02 2308 23 index index NN cord-014516-r59usk02 2308 24 ( ( -LRB- cord-014516-r59usk02 2308 25 BFI BFI NNP cord-014516-r59usk02 2308 26 ) ) -RRB- cord-014516-r59usk02 2308 27 , , , cord-014516-r59usk02 2308 28 muscle muscle NN cord-014516-r59usk02 2308 29 condition condition NN cord-014516-r59usk02 2308 30 score score NN cord-014516-r59usk02 2308 31 ( ( -LRB- cord-014516-r59usk02 2308 32 MCS MCS NNP cord-014516-r59usk02 2308 33 ) ) -RRB- cord-014516-r59usk02 2308 34 , , , cord-014516-r59usk02 2308 35 and and CC cord-014516-r59usk02 2308 36 feeding feeding NN cord-014516-r59usk02 2308 37 practices practice NNS cord-014516-r59usk02 2308 38 . . . cord-014516-r59usk02 2309 1 Quality quality NN cord-014516-r59usk02 2309 2 of of IN cord-014516-r59usk02 2309 3 life life NN cord-014516-r59usk02 2309 4 assessment assessment NN cord-014516-r59usk02 2309 5 by by IN cord-014516-r59usk02 2309 6 owners owner NNS cord-014516-r59usk02 2309 7 included include VBD cord-014516-r59usk02 2309 8 dog dog NN cord-014516-r59usk02 2309 9 's 's POS cord-014516-r59usk02 2309 10 level level NN cord-014516-r59usk02 2309 11 of of IN cord-014516-r59usk02 2309 12 energy energy NN cord-014516-r59usk02 2309 13 , , , cord-014516-r59usk02 2309 14 happiness happiness NN cord-014516-r59usk02 2309 15 , , , cord-014516-r59usk02 2309 16 appetite appetite NN cord-014516-r59usk02 2309 17 , , , cord-014516-r59usk02 2309 18 begging beg VBG cord-014516-r59usk02 2309 19 behavior behavior NN cord-014516-r59usk02 2309 20 , , , cord-014516-r59usk02 2309 21 flatulence flatulence NN cord-014516-r59usk02 2309 22 , , , cord-014516-r59usk02 2309 23 stool stool NN cord-014516-r59usk02 2309 24 volume volume NN cord-014516-r59usk02 2309 25 , , , cord-014516-r59usk02 2309 26 and and CC cord-014516-r59usk02 2309 27 fecal fecal JJ cord-014516-r59usk02 2309 28 score score NN cord-014516-r59usk02 2309 29 . . . cord-014516-r59usk02 2310 1 Statistical statistical JJ cord-014516-r59usk02 2310 2 analysis analysis NN cord-014516-r59usk02 2310 3 comprised comprise VBD cord-014516-r59usk02 2310 4 scatterplots scatterplots NNPS cord-014516-r59usk02 2310 5 , , , cord-014516-r59usk02 2310 6 regression regression NN cord-014516-r59usk02 2310 7 analysis analysis NN cord-014516-r59usk02 2310 8 , , , cord-014516-r59usk02 2310 9 summary summary NN cord-014516-r59usk02 2310 10 statistics statistic NNS cord-014516-r59usk02 2310 11 as as IN cord-014516-r59usk02 2310 12 appropriate appropriate JJ cord-014516-r59usk02 2310 13 for for IN cord-014516-r59usk02 2310 14 the the DT cord-014516-r59usk02 2310 15 type type NN cord-014516-r59usk02 2310 16 of of IN cord-014516-r59usk02 2310 17 analyses analysis NNS cord-014516-r59usk02 2310 18 performed perform VBN cord-014516-r59usk02 2310 19 ( ( -LRB- cord-014516-r59usk02 2310 20 continuous continuous JJ cord-014516-r59usk02 2310 21 or or CC cord-014516-r59usk02 2310 22 categorical categorical JJ cord-014516-r59usk02 2310 23 variables variable NNS cord-014516-r59usk02 2310 24 , , , cord-014516-r59usk02 2310 25 distribution distribution NN cord-014516-r59usk02 2310 26 ) ) -RRB- cord-014516-r59usk02 2310 27 , , , cord-014516-r59usk02 2310 28 and and CC cord-014516-r59usk02 2310 29 a a DT cord-014516-r59usk02 2310 30 mixed mixed JJ cord-014516-r59usk02 2310 31 model model NN cord-014516-r59usk02 2310 32 ANOVA ANOVA NNP cord-014516-r59usk02 2310 33 to to TO cord-014516-r59usk02 2310 34 assess assess VB cord-014516-r59usk02 2310 35 changes change NNS cord-014516-r59usk02 2310 36 over over IN cord-014516-r59usk02 2310 37 time time NN cord-014516-r59usk02 2310 38 ( ( -LRB- cord-014516-r59usk02 2310 39 with with IN cord-014516-r59usk02 2310 40 statistical statistical JJ cord-014516-r59usk02 2310 41 significance significance NN cord-014516-r59usk02 2310 42 at at IN cord-014516-r59usk02 2310 43 p p NN cord-014516-r59usk02 2310 44 < < XX cord-014516-r59usk02 2310 45 0.05 0.05 CD cord-014516-r59usk02 2310 46 ) ) -RRB- cord-014516-r59usk02 2310 47 . . . cord-014516-r59usk02 2311 1 Ninety ninety CD cord-014516-r59usk02 2311 2 four four CD cord-014516-r59usk02 2311 3 percent percent NN cord-014516-r59usk02 2311 4 of of IN cord-014516-r59usk02 2311 5 the the DT cord-014516-r59usk02 2311 6 dogs dog NNS cord-014516-r59usk02 2311 7 lost lose VBD cord-014516-r59usk02 2311 8 weight weight NN cord-014516-r59usk02 2311 9 ( ( -LRB- cord-014516-r59usk02 2311 10 n n NN cord-014516-r59usk02 2311 11 = = SYM cord-014516-r59usk02 2311 12 153 153 CD cord-014516-r59usk02 2311 13 ) ) -RRB- cord-014516-r59usk02 2311 14 with with IN cord-014516-r59usk02 2311 15 an an DT cord-014516-r59usk02 2311 16 average average JJ cord-014516-r59usk02 2311 17 weight weight NN cord-014516-r59usk02 2311 18 loss loss NN cord-014516-r59usk02 2311 19 of of IN cord-014516-r59usk02 2311 20 14.5 14.5 CD cord-014516-r59usk02 2311 21 % % NN cord-014516-r59usk02 2311 22 ( ( -LRB- cord-014516-r59usk02 2311 23 SEM SEM NNP cord-014516-r59usk02 2311 24 , , , cord-014516-r59usk02 2311 25 1.1 1.1 CD cord-014516-r59usk02 2311 26 % % NN cord-014516-r59usk02 2311 27 ) ) -RRB- cord-014516-r59usk02 2311 28 over over IN cord-014516-r59usk02 2311 29 6 6 CD cord-014516-r59usk02 2311 30 months month NNS cord-014516-r59usk02 2311 31 and and CC cord-014516-r59usk02 2311 32 an an DT cord-014516-r59usk02 2311 33 average average JJ cord-014516-r59usk02 2311 34 weekly weekly JJ cord-014516-r59usk02 2311 35 weight weight NN cord-014516-r59usk02 2311 36 - - HYPH cord-014516-r59usk02 2311 37 loss loss NN cord-014516-r59usk02 2311 38 rate rate NN cord-014516-r59usk02 2311 39 of of IN cord-014516-r59usk02 2311 40 0.73 0.73 CD cord-014516-r59usk02 2311 41 % % NN cord-014516-r59usk02 2311 42 ( ( -LRB- cord-014516-r59usk02 2311 43 SEM SEM NNP cord-014516-r59usk02 2311 44 , , , cord-014516-r59usk02 2311 45 0.04 0.04 CD cord-014516-r59usk02 2311 46 % % NN cord-014516-r59usk02 2311 47 ) ) -RRB- cord-014516-r59usk02 2311 48 . . . cord-014516-r59usk02 2312 1 The the DT cord-014516-r59usk02 2312 2 mean mean JJ cord-014516-r59usk02 2312 3 duration duration NN cord-014516-r59usk02 2312 4 of of IN cord-014516-r59usk02 2312 5 weight weight NN cord-014516-r59usk02 2312 6 loss loss NN cord-014516-r59usk02 2312 7 was be VBD cord-014516-r59usk02 2312 8 127 127 CD cord-014516-r59usk02 2312 9 days day NNS cord-014516-r59usk02 2312 10 ( ( -LRB- cord-014516-r59usk02 2312 11 SEM SEM NNP cord-014516-r59usk02 2312 12 , , , cord-014516-r59usk02 2312 13 4.3 4.3 CD cord-014516-r59usk02 2312 14 days day NNS cord-014516-r59usk02 2312 15 ) ) -RRB- cord-014516-r59usk02 2312 16 with with IN cord-014516-r59usk02 2312 17 an an DT cord-014516-r59usk02 2312 18 average average NN cord-014516-r59usk02 2312 19 of of IN cord-014516-r59usk02 2312 20 33 33 CD cord-014516-r59usk02 2312 21 days day NNS cord-014516-r59usk02 2312 22 ( ( -LRB- cord-014516-r59usk02 2312 23 SEM SEM NNP cord-014516-r59usk02 2312 24 , , , cord-014516-r59usk02 2312 25 0.7 0.7 CD cord-014516-r59usk02 2312 26 days day NNS cord-014516-r59usk02 2312 27 ) ) -RRB- cord-014516-r59usk02 2312 28 between between IN cord-014516-r59usk02 2312 29 rechecks recheck NNS cord-014516-r59usk02 2312 30 . . . cord-014516-r59usk02 2313 1 Thirty thirty CD cord-014516-r59usk02 2313 2 nine nine CD cord-014516-r59usk02 2313 3 percent percent NN cord-014516-r59usk02 2313 4 of of IN cord-014516-r59usk02 2313 5 dogs dog NNS cord-014516-r59usk02 2313 6 achieved achieve VBN cord-014516-r59usk02 2313 7 IBW IBW NNP cord-014516-r59usk02 2313 8 ( ( -LRB- cord-014516-r59usk02 2313 9 0.39 0.39 CD cord-014516-r59usk02 2313 10 , , , cord-014516-r59usk02 2313 11 CI CI NNP cord-014516-r59usk02 2313 12 : : : cord-014516-r59usk02 2313 13 0.31 0.31 CD cord-014516-r59usk02 2313 14 - - HYPH cord-014516-r59usk02 2313 15 0.48 0.48 CD cord-014516-r59usk02 2313 16 ) ) -RRB- cord-014516-r59usk02 2313 17 . . . cord-014516-r59usk02 2314 1 Fifty fifty CD cord-014516-r59usk02 2314 2 five five CD cord-014516-r59usk02 2314 3 percent percent NN cord-014516-r59usk02 2314 4 of of IN cord-014516-r59usk02 2314 5 dogs dog NNS cord-014516-r59usk02 2314 6 ate eat VBD cord-014516-r59usk02 2314 7 more more JJR cord-014516-r59usk02 2314 8 calories calorie NNS cord-014516-r59usk02 2314 9 from from IN cord-014516-r59usk02 2314 10 NDWMF NDWMF NNP cord-014516-r59usk02 2314 11 * * NFP cord-014516-r59usk02 2314 12 than than IN cord-014516-r59usk02 2314 13 the the DT cord-014516-r59usk02 2314 14 recommended recommend VBN cord-014516-r59usk02 2314 15 DER DER NNP cord-014516-r59usk02 2314 16 for for IN cord-014516-r59usk02 2314 17 weight weight NN cord-014516-r59usk02 2314 18 loss loss NN cord-014516-r59usk02 2314 19 ( ( -LRB- cord-014516-r59usk02 2314 20 median median NN cord-014516-r59usk02 2314 21 fed feed VBN cord-014516-r59usk02 2314 22 above above RB cord-014516-r59usk02 2314 23 DER=8 DER=8 VBZ cord-014516-r59usk02 2314 24 % % NN cord-014516-r59usk02 2314 25 ) ) -RRB- cord-014516-r59usk02 2314 26 and and CC cord-014516-r59usk02 2314 27 94 94 CD cord-014516-r59usk02 2314 28 % % NN cord-014516-r59usk02 2314 29 of of IN cord-014516-r59usk02 2314 30 these these DT cord-014516-r59usk02 2314 31 dogs dog NNS cord-014516-r59usk02 2314 32 ( ( -LRB- cord-014516-r59usk02 2314 33 0.94 0.94 CD cord-014516-r59usk02 2314 34 , , , cord-014516-r59usk02 2314 35 CI CI NNP cord-014516-r59usk02 2314 36 : : : cord-014516-r59usk02 2314 37 0.87 0.87 CD cord-014516-r59usk02 2314 38 - - HYPH cord-014516-r59usk02 2314 39 0.98 0.98 CD cord-014516-r59usk02 2314 40 ) ) -RRB- cord-014516-r59usk02 2314 41 still still RB cord-014516-r59usk02 2314 42 lost lose VBD cord-014516-r59usk02 2314 43 weight weight NN cord-014516-r59usk02 2314 44 . . . cord-014516-r59usk02 2315 1 Thirty thirty CD cord-014516-r59usk02 2315 2 six six CD cord-014516-r59usk02 2315 3 percent percent NN cord-014516-r59usk02 2315 4 of of IN cord-014516-r59usk02 2315 5 dogs dog NNS cord-014516-r59usk02 2315 6 received receive VBD cord-014516-r59usk02 2315 7 treats treat NNS cord-014516-r59usk02 2315 8 . . . cord-014516-r59usk02 2316 1 BCS BCS NNP cord-014516-r59usk02 2316 2 and and CC cord-014516-r59usk02 2316 3 BFI BFI NNP cord-014516-r59usk02 2316 4 decreased decrease VBD cord-014516-r59usk02 2316 5 significantly significantly RB cord-014516-r59usk02 2316 6 over over IN cord-014516-r59usk02 2316 7 time time NN cord-014516-r59usk02 2316 8 compared compare VBN cord-014516-r59usk02 2316 9 to to IN cord-014516-r59usk02 2316 10 baseline baseline NN cord-014516-r59usk02 2316 11 . . . cord-014516-r59usk02 2317 1 Owners owner NNS cord-014516-r59usk02 2317 2 perceived perceive VBD cord-014516-r59usk02 2317 3 a a DT cord-014516-r59usk02 2317 4 significant significant JJ cord-014516-r59usk02 2317 5 increase increase NN cord-014516-r59usk02 2317 6 in in IN cord-014516-r59usk02 2317 7 energy energy NN cord-014516-r59usk02 2317 8 and and CC cord-014516-r59usk02 2317 9 happiness happiness NN cord-014516-r59usk02 2317 10 in in IN cord-014516-r59usk02 2317 11 the the DT cord-014516-r59usk02 2317 12 dogs dog NNS cord-014516-r59usk02 2317 13 that that WDT cord-014516-r59usk02 2317 14 lost lose VBD cord-014516-r59usk02 2317 15 weight weight NN cord-014516-r59usk02 2317 16 without without IN cord-014516-r59usk02 2317 17 changes change NNS cord-014516-r59usk02 2317 18 in in IN cord-014516-r59usk02 2317 19 appetite appetite NN cord-014516-r59usk02 2317 20 or or CC cord-014516-r59usk02 2317 21 begging beg VBG cord-014516-r59usk02 2317 22 behavior behavior NN cord-014516-r59usk02 2317 23 . . . cord-014516-r59usk02 2318 1 In in IN cord-014516-r59usk02 2318 2 conclusion conclusion NN cord-014516-r59usk02 2318 3 , , , cord-014516-r59usk02 2318 4 this this DT cord-014516-r59usk02 2318 5 clinical clinical JJ cord-014516-r59usk02 2318 6 study study NN cord-014516-r59usk02 2318 7 confirmed confirm VBD cord-014516-r59usk02 2318 8 the the DT cord-014516-r59usk02 2318 9 effectiveness effectiveness NN cord-014516-r59usk02 2318 10 of of IN cord-014516-r59usk02 2318 11 the the DT cord-014516-r59usk02 2318 12 NDWMF NDWMF NNP cord-014516-r59usk02 2318 13 * * NFP cord-014516-r59usk02 2318 14 in in IN cord-014516-r59usk02 2318 15 achieving achieve VBG cord-014516-r59usk02 2318 16 weight weight NN cord-014516-r59usk02 2318 17 loss loss NN cord-014516-r59usk02 2318 18 in in IN cord-014516-r59usk02 2318 19 overweight overweight JJ cord-014516-r59usk02 2318 20 / / SYM cord-014516-r59usk02 2318 21 obese obese JJ cord-014516-r59usk02 2318 22 client client NN cord-014516-r59usk02 2318 23 - - HYPH cord-014516-r59usk02 2318 24 owned own VBN cord-014516-r59usk02 2318 25 dogs dog NNS cord-014516-r59usk02 2318 26 in in IN cord-014516-r59usk02 2318 27 spite spite NN cord-014516-r59usk02 2318 28 of of IN cord-014516-r59usk02 2318 29 higher high JJR cord-014516-r59usk02 2318 30 than than IN cord-014516-r59usk02 2318 31 recommended recommend VBN cord-014516-r59usk02 2318 32 caloric caloric JJ cord-014516-r59usk02 2318 33 intake intake NN cord-014516-r59usk02 2318 34 . . . cord-014516-r59usk02 2319 1 Owners owner NNS cord-014516-r59usk02 2319 2 reported report VBD cord-014516-r59usk02 2319 3 significant significant JJ cord-014516-r59usk02 2319 4 improvements improvement NNS cord-014516-r59usk02 2319 5 in in IN cord-014516-r59usk02 2319 6 dog dog NN cord-014516-r59usk02 2319 7 's 's POS cord-014516-r59usk02 2319 8 quality quality NN cord-014516-r59usk02 2319 9 of of IN cord-014516-r59usk02 2319 10 life life NN cord-014516-r59usk02 2319 11 without without IN cord-014516-r59usk02 2319 12 negative negative JJ cord-014516-r59usk02 2319 13 side side NN cord-014516-r59usk02 2319 14 effects effect NNS cord-014516-r59usk02 2319 15 . . . cord-014516-r59usk02 2320 1 * * NFP cord-014516-r59usk02 2320 2 Haptoglobin Haptoglobin NNP cord-014516-r59usk02 2320 3 is be VBZ cord-014516-r59usk02 2320 4 a a DT cord-014516-r59usk02 2320 5 moderate moderate JJ cord-014516-r59usk02 2320 6 acute acute JJ cord-014516-r59usk02 2320 7 phase phase NN cord-014516-r59usk02 2320 8 protein protein NN cord-014516-r59usk02 2320 9 in in IN cord-014516-r59usk02 2320 10 cats cat NNS cord-014516-r59usk02 2320 11 . . . cord-014516-r59usk02 2321 1 As as IN cord-014516-r59usk02 2321 2 a a DT cord-014516-r59usk02 2321 3 part part NN cord-014516-r59usk02 2321 4 of of IN cord-014516-r59usk02 2321 5 the the DT cord-014516-r59usk02 2321 6 innate innate JJ cord-014516-r59usk02 2321 7 immune immune JJ cord-014516-r59usk02 2321 8 system system NN cord-014516-r59usk02 2321 9 its -PRON- PRP$ cord-014516-r59usk02 2321 10 concentration concentration NN cord-014516-r59usk02 2321 11 rises rise VBZ cord-014516-r59usk02 2321 12 within within IN cord-014516-r59usk02 2321 13 24 24 CD cord-014516-r59usk02 2321 14 - - SYM cord-014516-r59usk02 2321 15 48 48 CD cord-014516-r59usk02 2321 16 hours hour NNS cord-014516-r59usk02 2321 17 after after IN cord-014516-r59usk02 2321 18 tissue tissue NN cord-014516-r59usk02 2321 19 damage damage NN cord-014516-r59usk02 2321 20 . . . cord-014516-r59usk02 2322 1 Aim Aim NNP cord-014516-r59usk02 2322 2 of of IN cord-014516-r59usk02 2322 3 the the DT cord-014516-r59usk02 2322 4 study study NN cord-014516-r59usk02 2322 5 was be VBD cord-014516-r59usk02 2322 6 to to TO cord-014516-r59usk02 2322 7 validate validate VB cord-014516-r59usk02 2322 8 an an DT cord-014516-r59usk02 2322 9 ELISA ELISA NNP cord-014516-r59usk02 2322 10 which which WDT cord-014516-r59usk02 2322 11 was be VBD cord-014516-r59usk02 2322 12 recently recently RB cord-014516-r59usk02 2322 13 developed develop VBN cord-014516-r59usk02 2322 14 for for IN cord-014516-r59usk02 2322 15 the the DT cord-014516-r59usk02 2322 16 measurement measurement NN cord-014516-r59usk02 2322 17 of of IN cord-014516-r59usk02 2322 18 feline feline JJ cord-014516-r59usk02 2322 19 haptoglobin haptoglobin NN cord-014516-r59usk02 2322 20 and and CC cord-014516-r59usk02 2322 21 to to TO cord-014516-r59usk02 2322 22 compare compare VB cord-014516-r59usk02 2322 23 it -PRON- PRP cord-014516-r59usk02 2322 24 with with IN cord-014516-r59usk02 2322 25 a a DT cord-014516-r59usk02 2322 26 commonly commonly RB cord-014516-r59usk02 2322 27 used use VBN cord-014516-r59usk02 2322 28 spectrophotometric spectrophotometric JJ cord-014516-r59usk02 2322 29 assay assay NN cord-014516-r59usk02 2322 30 . . . cord-014516-r59usk02 2323 1 The the DT cord-014516-r59usk02 2323 2 concentration concentration NN cord-014516-r59usk02 2323 3 of of IN cord-014516-r59usk02 2323 4 haptoglobin haptoglobin NN cord-014516-r59usk02 2323 5 was be VBD cord-014516-r59usk02 2323 6 measured measure VBN cord-014516-r59usk02 2323 7 in in IN cord-014516-r59usk02 2323 8 38 38 CD cord-014516-r59usk02 2323 9 healthy healthy JJ cord-014516-r59usk02 2323 10 and and CC cord-014516-r59usk02 2323 11 sick sick JJ cord-014516-r59usk02 2323 12 cats cat NNS cord-014516-r59usk02 2323 13 using use VBG cord-014516-r59usk02 2323 14 a a DT cord-014516-r59usk02 2323 15 sandwich sandwich NN cord-014516-r59usk02 2323 16 - - HYPH cord-014516-r59usk02 2323 17 ELISA ELISA NNP cord-014516-r59usk02 2323 18 ( ( -LRB- cord-014516-r59usk02 2323 19 TECOmedical TECOmedical NNP cord-014516-r59usk02 2323 20 Group Group NNP cord-014516-r59usk02 2323 21 , , , cord-014516-r59usk02 2323 22 Rheinbach Rheinbach NNP cord-014516-r59usk02 2323 23 , , , cord-014516-r59usk02 2323 24 Germany Germany NNP cord-014516-r59usk02 2323 25 ) ) -RRB- cord-014516-r59usk02 2323 26 . . . cord-014516-r59usk02 2324 1 The the DT cord-014516-r59usk02 2324 2 validation validation NN cord-014516-r59usk02 2324 3 included include VBD cord-014516-r59usk02 2324 4 the the DT cord-014516-r59usk02 2324 5 detection detection NN cord-014516-r59usk02 2324 6 of of IN cord-014516-r59usk02 2324 7 intra intra JJ cord-014516-r59usk02 2324 8 - - JJ cord-014516-r59usk02 2324 9 assay assay JJ cord-014516-r59usk02 2324 10 and and CC cord-014516-r59usk02 2324 11 inter inter JJ cord-014516-r59usk02 2324 12 - - JJ cord-014516-r59usk02 2324 13 assay assay JJ cord-014516-r59usk02 2324 14 variation variation NN cord-014516-r59usk02 2324 15 , , , cord-014516-r59usk02 2324 16 dilution dilution NN cord-014516-r59usk02 2324 17 linearity linearity NN cord-014516-r59usk02 2324 18 , , , cord-014516-r59usk02 2324 19 spike spike NN cord-014516-r59usk02 2324 20 recovery recovery NN cord-014516-r59usk02 2324 21 and and CC cord-014516-r59usk02 2324 22 lower low JJR cord-014516-r59usk02 2324 23 detection detection NN cord-014516-r59usk02 2324 24 limit limit NN cord-014516-r59usk02 2324 25 . . . cord-014516-r59usk02 2325 1 A a DT cord-014516-r59usk02 2325 2 spectrophotometric spectrophotometric JJ cord-014516-r59usk02 2325 3 assay assay NN cord-014516-r59usk02 2325 4 ( ( -LRB- cord-014516-r59usk02 2325 5 Tridelta Tridelta NNP cord-014516-r59usk02 2325 6 Development Development NNP cord-014516-r59usk02 2325 7 Ltd Ltd NNP cord-014516-r59usk02 2325 8 , , , cord-014516-r59usk02 2325 9 Maynooth Maynooth NNP cord-014516-r59usk02 2325 10 , , , cord-014516-r59usk02 2325 11 Ireland Ireland NNP cord-014516-r59usk02 2325 12 ) ) -RRB- cord-014516-r59usk02 2325 13 was be VBD cord-014516-r59usk02 2325 14 used use VBN cord-014516-r59usk02 2325 15 as as IN cord-014516-r59usk02 2325 16 a a DT cord-014516-r59usk02 2325 17 reference reference NN cord-014516-r59usk02 2325 18 method method NN cord-014516-r59usk02 2325 19 . . . cord-014516-r59usk02 2326 1 All all DT cord-014516-r59usk02 2326 2 samples sample NNS cord-014516-r59usk02 2326 3 were be VBD cord-014516-r59usk02 2326 4 measured measure VBN cord-014516-r59usk02 2326 5 in in IN cord-014516-r59usk02 2326 6 duplicate duplicate NN cord-014516-r59usk02 2326 7 . . . cord-014516-r59usk02 2327 1 Statistical statistical JJ cord-014516-r59usk02 2327 2 analysis analysis NN cord-014516-r59usk02 2327 3 was be VBD cord-014516-r59usk02 2327 4 performed perform VBN cord-014516-r59usk02 2327 5 using use VBG cord-014516-r59usk02 2327 6 IBM IBM NNP cord-014516-r59usk02 2327 7 â â CD cord-014516-r59usk02 2327 8 SPSS SPSS NNP cord-014516-r59usk02 2328 1 â â LS cord-014516-r59usk02 2328 2 Statistics statistic NNS cord-014516-r59usk02 2328 3 20 20 CD cord-014516-r59usk02 2328 4 ( ( -LRB- cord-014516-r59usk02 2328 5 IBM IBM NNP cord-014516-r59usk02 2328 6 Corporation Corporation NNP cord-014516-r59usk02 2328 7 â â , cord-014516-r59usk02 2328 8 ) ) -RRB- cord-014516-r59usk02 2328 9 and and CC cord-014516-r59usk02 2328 10 included include VBD cord-014516-r59usk02 2328 11 descriptive descriptive JJ cord-014516-r59usk02 2328 12 statistics statistic NNS cord-014516-r59usk02 2328 13 , , , cord-014516-r59usk02 2328 14 Spearman Spearman NNP cord-014516-r59usk02 2328 15 correlation correlation NN cord-014516-r59usk02 2328 16 ( ( -LRB- cord-014516-r59usk02 2328 17 rs rs NN cord-014516-r59usk02 2328 18 ) ) -RRB- cord-014516-r59usk02 2328 19 and and CC cord-014516-r59usk02 2328 20 coefficients coefficient NNS cord-014516-r59usk02 2328 21 of of IN cord-014516-r59usk02 2328 22 variation variation NN cord-014516-r59usk02 2328 23 ( ( -LRB- cord-014516-r59usk02 2328 24 CV cv NN cord-014516-r59usk02 2328 25 ) ) -RRB- cord-014516-r59usk02 2328 26 . . . cord-014516-r59usk02 2329 1 The the DT cord-014516-r59usk02 2329 2 coefficients coefficient NNS cord-014516-r59usk02 2329 3 of of IN cord-014516-r59usk02 2329 4 variation variation NN cord-014516-r59usk02 2329 5 were be VBD cord-014516-r59usk02 2329 6 2.3 2.3 CD cord-014516-r59usk02 2329 7 % % NN cord-014516-r59usk02 2329 8 , , , cord-014516-r59usk02 2329 9 2.9 2.9 CD cord-014516-r59usk02 2329 10 % % NN cord-014516-r59usk02 2329 11 and and CC cord-014516-r59usk02 2329 12 4.6 4.6 CD cord-014516-r59usk02 2329 13 % % NN cord-014516-r59usk02 2329 14 for for IN cord-014516-r59usk02 2329 15 intra intra JJ cord-014516-r59usk02 2329 16 - - JJ cord-014516-r59usk02 2329 17 assay assay JJ cord-014516-r59usk02 2329 18 variability variability NN cord-014516-r59usk02 2329 19 and and CC cord-014516-r59usk02 2329 20 5.1 5.1 CD cord-014516-r59usk02 2329 21 % % NN cord-014516-r59usk02 2329 22 , , , cord-014516-r59usk02 2329 23 8.8 8.8 CD cord-014516-r59usk02 2329 24 % % NN cord-014516-r59usk02 2329 25 and and CC cord-014516-r59usk02 2329 26 11.2 11.2 CD cord-014516-r59usk02 2329 27 % % NN cord-014516-r59usk02 2329 28 for for IN cord-014516-r59usk02 2329 29 inter inter JJ cord-014516-r59usk02 2329 30 - - JJ cord-014516-r59usk02 2329 31 assay assay JJ cord-014516-r59usk02 2329 32 variability variability NN cord-014516-r59usk02 2329 33 . . . cord-014516-r59usk02 2330 1 The the DT cord-014516-r59usk02 2330 2 ratio ratio NN cord-014516-r59usk02 2330 3 of of IN cord-014516-r59usk02 2330 4 observed observe VBN cord-014516-r59usk02 2330 5 to to TO cord-014516-r59usk02 2330 6 expected expect VBN cord-014516-r59usk02 2330 7 dilutional dilutional JJ cord-014516-r59usk02 2330 8 parallelism parallelism NN cord-014516-r59usk02 2330 9 of of IN cord-014516-r59usk02 2330 10 4 4 CD cord-014516-r59usk02 2330 11 serum serum NN cord-014516-r59usk02 2330 12 samples sample NNS cord-014516-r59usk02 2330 13 diluted dilute VBD cord-014516-r59usk02 2330 14 3 3 CD cord-014516-r59usk02 2330 15 times time NNS cord-014516-r59usk02 2330 16 ranged range VBD cord-014516-r59usk02 2330 17 from from IN cord-014516-r59usk02 2330 18 108 108 CD cord-014516-r59usk02 2330 19 to to TO cord-014516-r59usk02 2330 20 118 118 CD cord-014516-r59usk02 2330 21 % % NN cord-014516-r59usk02 2330 22 . . . cord-014516-r59usk02 2331 1 The the DT cord-014516-r59usk02 2331 2 ratio ratio NN cord-014516-r59usk02 2331 3 of of IN cord-014516-r59usk02 2331 4 observed observe VBN cord-014516-r59usk02 2331 5 to to TO cord-014516-r59usk02 2331 6 expected expect VBN cord-014516-r59usk02 2331 7 spike spike NN cord-014516-r59usk02 2331 8 recovery recovery NN cord-014516-r59usk02 2331 9 of of IN cord-014516-r59usk02 2331 10 4 4 CD cord-014516-r59usk02 2331 11 serum serum NN cord-014516-r59usk02 2331 12 samples sample NNS cord-014516-r59usk02 2331 13 ranged range VBD cord-014516-r59usk02 2331 14 from from IN cord-014516-r59usk02 2331 15 91 91 CD cord-014516-r59usk02 2331 16 % % NN cord-014516-r59usk02 2331 17 to to IN cord-014516-r59usk02 2331 18 94 94 CD cord-014516-r59usk02 2331 19 % % NN cord-014516-r59usk02 2331 20 . . . cord-014516-r59usk02 2332 1 The the DT cord-014516-r59usk02 2332 2 lower low JJR cord-014516-r59usk02 2332 3 detection detection NN cord-014516-r59usk02 2332 4 limit limit NN cord-014516-r59usk02 2332 5 was be VBD cord-014516-r59usk02 2332 6 0.19 0.19 CD cord-014516-r59usk02 2332 7 mg mg NNP cord-014516-r59usk02 2332 8 / / SYM cord-014516-r59usk02 2332 9 ml ml NN cord-014516-r59usk02 2332 10 . . . cord-014516-r59usk02 2333 1 The the DT cord-014516-r59usk02 2333 2 correlation correlation NN cord-014516-r59usk02 2333 3 between between IN cord-014516-r59usk02 2333 4 the the DT cord-014516-r59usk02 2333 5 2 2 CD cord-014516-r59usk02 2333 6 assays assay NNS cord-014516-r59usk02 2333 7 was be VBD cord-014516-r59usk02 2333 8 significantly significantly RB cord-014516-r59usk02 2333 9 strong strong JJ cord-014516-r59usk02 2334 1 ( ( -LRB- cord-014516-r59usk02 2334 2 rs rs NNP cord-014516-r59usk02 2334 3 = = SYM cord-014516-r59usk02 2334 4 0.94 0.94 CD cord-014516-r59usk02 2334 5 , , , cord-014516-r59usk02 2334 6 P p NN cord-014516-r59usk02 2334 7 < < XX cord-014516-r59usk02 2334 8 0.001 0.001 CD cord-014516-r59usk02 2334 9 ) ) -RRB- cord-014516-r59usk02 2334 10 . . . cord-014516-r59usk02 2335 1 The the DT cord-014516-r59usk02 2335 2 recently recently RB cord-014516-r59usk02 2335 3 available available JJ cord-014516-r59usk02 2335 4 sandwich sandwich NN cord-014516-r59usk02 2335 5 - - HYPH cord-014516-r59usk02 2335 6 ELISA ELISA NNP cord-014516-r59usk02 2335 7 provides provide VBZ cord-014516-r59usk02 2335 8 a a DT cord-014516-r59usk02 2335 9 high high JJ cord-014516-r59usk02 2335 10 accuracy accuracy NN cord-014516-r59usk02 2335 11 and and CC cord-014516-r59usk02 2335 12 precision precision NN cord-014516-r59usk02 2335 13 and and CC cord-014516-r59usk02 2335 14 can can MD cord-014516-r59usk02 2335 15 therefore therefore RB cord-014516-r59usk02 2335 16 be be VB cord-014516-r59usk02 2335 17 used use VBN cord-014516-r59usk02 2335 18 for for IN cord-014516-r59usk02 2335 19 the the DT cord-014516-r59usk02 2335 20 measurement measurement NN cord-014516-r59usk02 2335 21 of of IN cord-014516-r59usk02 2335 22 feline feline JJ cord-014516-r59usk02 2335 23 haptoglobin haptoglobin NN cord-014516-r59usk02 2335 24 . . . cord-014516-r59usk02 2336 1 The the DT cord-014516-r59usk02 2336 2 3rd 3rd JJ cord-014516-r59usk02 2336 3 and and CC cord-014516-r59usk02 2336 4 4th 4th JJ cord-014516-r59usk02 2336 5 author author NN cord-014516-r59usk02 2336 6 ( ( -LRB- cord-014516-r59usk02 2336 7 M. M. NNP cord-014516-r59usk02 2336 8 Hennies Hennies NNP cord-014516-r59usk02 2336 9 and and CC cord-014516-r59usk02 2336 10 C. C. NNP cord-014516-r59usk02 2336 11 Wienen Wienen NNP cord-014516-r59usk02 2336 12 ) ) -RRB- cord-014516-r59usk02 2336 13 work work VB cord-014516-r59usk02 2336 14 for for IN cord-014516-r59usk02 2336 15 the the DT cord-014516-r59usk02 2336 16 company company NN cord-014516-r59usk02 2336 17 TECOmedical TECOmedical NNP cord-014516-r59usk02 2336 18 Group Group NNP cord-014516-r59usk02 2336 19 that that WDT cord-014516-r59usk02 2336 20 developed develop VBD cord-014516-r59usk02 2336 21 the the DT cord-014516-r59usk02 2336 22 ELISA ELISA NNP cord-014516-r59usk02 2336 23 which which WDT cord-014516-r59usk02 2336 24 was be VBD cord-014516-r59usk02 2336 25 evaluated evaluate VBN cord-014516-r59usk02 2336 26 in in IN cord-014516-r59usk02 2336 27 the the DT cord-014516-r59usk02 2336 28 study study NN cord-014516-r59usk02 2336 29 . . . cord-014516-r59usk02 2337 1 They -PRON- PRP cord-014516-r59usk02 2337 2 provided provide VBD cord-014516-r59usk02 2337 3 the the DT cord-014516-r59usk02 2337 4 kits kit NNS cord-014516-r59usk02 2337 5 and and CC cord-014516-r59usk02 2337 6 they -PRON- PRP cord-014516-r59usk02 2337 7 helped help VBD cord-014516-r59usk02 2337 8 with with IN cord-014516-r59usk02 2337 9 performing perform VBG cord-014516-r59usk02 2337 10 the the DT cord-014516-r59usk02 2337 11 tests test NNS cord-014516-r59usk02 2337 12 , , , cord-014516-r59usk02 2337 13 but but CC cord-014516-r59usk02 2337 14 they -PRON- PRP cord-014516-r59usk02 2337 15 did do VBD cord-014516-r59usk02 2337 16 not not RB cord-014516-r59usk02 2337 17 have have VB cord-014516-r59usk02 2337 18 any any DT cord-014516-r59usk02 2337 19 influence influence NN cord-014516-r59usk02 2337 20 on on IN cord-014516-r59usk02 2337 21 the the DT cord-014516-r59usk02 2337 22 results result NNS cord-014516-r59usk02 2337 23 and and CC cord-014516-r59usk02 2337 24 the the DT cord-014516-r59usk02 2337 25 interpretation interpretation NN cord-014516-r59usk02 2337 26 of of IN cord-014516-r59usk02 2337 27 the the DT cord-014516-r59usk02 2337 28 data datum NNS cord-014516-r59usk02 2337 29 . . . cord-014516-r59usk02 2338 1 Canine canine JJ cord-014516-r59usk02 2338 2 idiopathic idiopathic JJ cord-014516-r59usk02 2338 3 pulmonary pulmonary JJ cord-014516-r59usk02 2338 4 fibrosis fibrosis NN cord-014516-r59usk02 2338 5 ( ( -LRB- cord-014516-r59usk02 2338 6 CIPF CIPF NNP cord-014516-r59usk02 2338 7 ) ) -RRB- cord-014516-r59usk02 2338 8 is be VBZ cord-014516-r59usk02 2338 9 a a DT cord-014516-r59usk02 2338 10 progressive progressive JJ cord-014516-r59usk02 2338 11 interstitial interstitial JJ cord-014516-r59usk02 2338 12 lung lung NN cord-014516-r59usk02 2338 13 disease disease NN cord-014516-r59usk02 2338 14 that that WDT cord-014516-r59usk02 2338 15 mainly mainly RB cord-014516-r59usk02 2338 16 occurs occur VBZ cord-014516-r59usk02 2338 17 in in IN cord-014516-r59usk02 2338 18 the the DT cord-014516-r59usk02 2338 19 West West NNP cord-014516-r59usk02 2338 20 Highland Highland NNP cord-014516-r59usk02 2338 21 white white JJ cord-014516-r59usk02 2338 22 terrier terrier NNP cord-014516-r59usk02 2338 23 ( ( -LRB- cord-014516-r59usk02 2338 24 WHWT WHWT NNP cord-014516-r59usk02 2338 25 ) ) -RRB- cord-014516-r59usk02 2338 26 breed breed NN cord-014516-r59usk02 2338 27 . . . cord-014516-r59usk02 2339 1 The the DT cord-014516-r59usk02 2339 2 CIPF CIPF NNP cord-014516-r59usk02 2339 3 diagnosis diagnosis NN cord-014516-r59usk02 2339 4 commonly commonly RB cord-014516-r59usk02 2339 5 relies rely VBZ cord-014516-r59usk02 2339 6 on on IN cord-014516-r59usk02 2339 7 thoracic thoracic JJ cord-014516-r59usk02 2339 8 high high JJ cord-014516-r59usk02 2339 9 - - HYPH cord-014516-r59usk02 2339 10 resolution resolution NN cord-014516-r59usk02 2339 11 computed compute VBN cord-014516-r59usk02 2339 12 tomography tomography NN cord-014516-r59usk02 2339 13 ( ( -LRB- cord-014516-r59usk02 2339 14 HRCT HRCT NNP cord-014516-r59usk02 2339 15 ) ) -RRB- cord-014516-r59usk02 2339 16 findings finding NNS cord-014516-r59usk02 2339 17 and and CC cord-014516-r59usk02 2339 18 ultimately ultimately RB cord-014516-r59usk02 2339 19 on on IN cord-014516-r59usk02 2339 20 histopathology histopathology NN cord-014516-r59usk02 2339 21 . . . cord-014516-r59usk02 2340 1 As as IN cord-014516-r59usk02 2340 2 those those DT cord-014516-r59usk02 2340 3 tests test NNS cord-014516-r59usk02 2340 4 are be VBP cord-014516-r59usk02 2340 5 not not RB cord-014516-r59usk02 2340 6 easily easily RB cord-014516-r59usk02 2340 7 performed perform VBN cord-014516-r59usk02 2340 8 in in IN cord-014516-r59usk02 2340 9 practice practice NN cord-014516-r59usk02 2340 10 , , , cord-014516-r59usk02 2340 11 identification identification NN cord-014516-r59usk02 2340 12 of of IN cord-014516-r59usk02 2340 13 measurable measurable JJ cord-014516-r59usk02 2340 14 markers marker NNS cord-014516-r59usk02 2340 15 of of IN cord-014516-r59usk02 2340 16 fibrosis fibrosis NN cord-014516-r59usk02 2340 17 , , , cord-014516-r59usk02 2340 18 that that WDT cord-014516-r59usk02 2340 19 might may MD cord-014516-r59usk02 2340 20 help help VB cord-014516-r59usk02 2340 21 to to TO cord-014516-r59usk02 2340 22 diagnose diagnose VB cord-014516-r59usk02 2340 23 and/or and/or CC cord-014516-r59usk02 2340 24 monitor monitor VB cord-014516-r59usk02 2340 25 the the DT cord-014516-r59usk02 2340 26 course course NN cord-014516-r59usk02 2340 27 of of IN cord-014516-r59usk02 2340 28 CIPF CIPF NNP cord-014516-r59usk02 2340 29 , , , cord-014516-r59usk02 2340 30 is be VBZ cord-014516-r59usk02 2340 31 helpful helpful JJ cord-014516-r59usk02 2340 32 . . . cord-014516-r59usk02 2341 1 VEGF VEGF NNP cord-014516-r59usk02 2341 2 is be VBZ cord-014516-r59usk02 2341 3 an an DT cord-014516-r59usk02 2341 4 angiogenic angiogenic JJ cord-014516-r59usk02 2341 5 regulator regulator NN cord-014516-r59usk02 2341 6 involved involve VBN cord-014516-r59usk02 2341 7 in in IN cord-014516-r59usk02 2341 8 a a DT cord-014516-r59usk02 2341 9 variety variety NN cord-014516-r59usk02 2341 10 of of IN cord-014516-r59usk02 2341 11 physiological physiological JJ cord-014516-r59usk02 2341 12 and and CC cord-014516-r59usk02 2341 13 pathological pathological JJ cord-014516-r59usk02 2341 14 processes process NNS cord-014516-r59usk02 2341 15 . . . cord-014516-r59usk02 2342 1 In in IN cord-014516-r59usk02 2342 2 human human JJ cord-014516-r59usk02 2342 3 IPF IPF NNP cord-014516-r59usk02 2342 4 , , , cord-014516-r59usk02 2342 5 serum serum NN cord-014516-r59usk02 2342 6 VEGF vegf NN cord-014516-r59usk02 2342 7 concentration concentration NN cord-014516-r59usk02 2342 8 has have VBZ cord-014516-r59usk02 2342 9 been be VBN cord-014516-r59usk02 2342 10 shown show VBN cord-014516-r59usk02 2342 11 to to TO cord-014516-r59usk02 2342 12 be be VB cord-014516-r59usk02 2342 13 higher high JJR cord-014516-r59usk02 2342 14 in in IN cord-014516-r59usk02 2342 15 IPF IPF NNP cord-014516-r59usk02 2342 16 patients patient NNS cord-014516-r59usk02 2342 17 compared compare VBN cord-014516-r59usk02 2342 18 to to IN cord-014516-r59usk02 2342 19 healthy healthy JJ cord-014516-r59usk02 2342 20 volunteers volunteer NNS cord-014516-r59usk02 2342 21 and and CC cord-014516-r59usk02 2342 22 may may MD cord-014516-r59usk02 2342 23 reflect reflect VB cord-014516-r59usk02 2342 24 the the DT cord-014516-r59usk02 2342 25 severity severity NN cord-014516-r59usk02 2342 26 of of IN cord-014516-r59usk02 2342 27 the the DT cord-014516-r59usk02 2342 28 lung lung NN cord-014516-r59usk02 2342 29 disease disease NN cord-014516-r59usk02 2342 30 . . . cord-014516-r59usk02 2343 1 The the DT cord-014516-r59usk02 2343 2 aims aim NNS cord-014516-r59usk02 2343 3 of of IN cord-014516-r59usk02 2343 4 the the DT cord-014516-r59usk02 2343 5 present present JJ cord-014516-r59usk02 2343 6 study study NN cord-014516-r59usk02 2343 7 were be VBD cord-014516-r59usk02 2343 8 ( ( -LRB- cord-014516-r59usk02 2343 9 1 1 CD cord-014516-r59usk02 2343 10 ) ) -RRB- cord-014516-r59usk02 2343 11 to to TO cord-014516-r59usk02 2343 12 investigate investigate VB cord-014516-r59usk02 2343 13 the the DT cord-014516-r59usk02 2343 14 potential potential JJ cord-014516-r59usk02 2343 15 role role NN cord-014516-r59usk02 2343 16 of of IN cord-014516-r59usk02 2343 17 VEGF VEGF NNP cord-014516-r59usk02 2343 18 as as IN cord-014516-r59usk02 2343 19 a a DT cord-014516-r59usk02 2343 20 peripheral peripheral JJ cord-014516-r59usk02 2343 21 blood blood NN cord-014516-r59usk02 2343 22 biomarker biomarker NN cord-014516-r59usk02 2343 23 in in IN cord-014516-r59usk02 2343 24 CIPF CIPF NNP cord-014516-r59usk02 2343 25 ; ; : cord-014516-r59usk02 2343 26 and and CC cord-014516-r59usk02 2343 27 ( ( -LRB- cord-014516-r59usk02 2343 28 2 2 LS cord-014516-r59usk02 2343 29 ) ) -RRB- cord-014516-r59usk02 2343 30 to to TO cord-014516-r59usk02 2343 31 investigate investigate VB cord-014516-r59usk02 2343 32 possible possible JJ cord-014516-r59usk02 2343 33 breed breed NN cord-014516-r59usk02 2343 34 - - HYPH cord-014516-r59usk02 2343 35 related relate VBN cord-014516-r59usk02 2343 36 differences difference NNS cord-014516-r59usk02 2343 37 in in IN cord-014516-r59usk02 2343 38 basal basal JJ cord-014516-r59usk02 2343 39 VEGF VEGF NNP cord-014516-r59usk02 2343 40 concentration concentration NN cord-014516-r59usk02 2343 41 , , , cord-014516-r59usk02 2343 42 that that WDT cord-014516-r59usk02 2343 43 might may MD cord-014516-r59usk02 2343 44 explain explain VB cord-014516-r59usk02 2343 45 the the DT cord-014516-r59usk02 2343 46 high high JJ cord-014516-r59usk02 2343 47 predisposition predisposition NN cord-014516-r59usk02 2343 48 of of IN cord-014516-r59usk02 2343 49 the the DT cord-014516-r59usk02 2343 50 WHWT whwt NN cord-014516-r59usk02 2343 51 breed breed NN cord-014516-r59usk02 2343 52 for for IN cord-014516-r59usk02 2343 53 CIPF.Therefore CIPF.Therefore NNS cord-014516-r59usk02 2344 1 , , , cord-014516-r59usk02 2344 2 VEGF VEGF NNP cord-014516-r59usk02 2344 3 was be VBD cord-014516-r59usk02 2344 4 determined determine VBN cord-014516-r59usk02 2344 5 by by IN cord-014516-r59usk02 2344 6 ELISA ELISA NNP cord-014516-r59usk02 2344 7 ( ( -LRB- cord-014516-r59usk02 2344 8 Canine canine JJ cord-014516-r59usk02 2344 9 VEGF VEGF NNP cord-014516-r59usk02 2344 10 Quantikine Quantikine NNP cord-014516-r59usk02 2344 11 ELISA ELISA NNP cord-014516-r59usk02 2344 12 Kit Kit NNP cord-014516-r59usk02 2344 13 , , , cord-014516-r59usk02 2344 14 R&D r&d NN cord-014516-r59usk02 2344 15 systems system NNS cord-014516-r59usk02 2344 16 ) ) -RRB- cord-014516-r59usk02 2344 17 in in IN cord-014516-r59usk02 2344 18 the the DT cord-014516-r59usk02 2344 19 serum serum NN cord-014516-r59usk02 2344 20 of of IN cord-014516-r59usk02 2344 21 14 14 CD cord-014516-r59usk02 2344 22 WHWT WHWT NNS cord-014516-r59usk02 2344 23 with with IN cord-014516-r59usk02 2344 24 CIPF CIPF NNP cord-014516-r59usk02 2344 25 confirmed confirm VBN cord-014516-r59usk02 2344 26 by by IN cord-014516-r59usk02 2344 27 HRCT HRCT NNP cord-014516-r59usk02 2344 28 and/or and/or CC cord-014516-r59usk02 2344 29 histopathology histopathology NN cord-014516-r59usk02 2344 30 ( ( -LRB- cord-014516-r59usk02 2344 31 median median JJ cord-014516-r59usk02 2344 32 age age NN cord-014516-r59usk02 2344 33 11 11 CD cord-014516-r59usk02 2344 34 years year NNS cord-014516-r59usk02 2344 35 , , , cord-014516-r59usk02 2344 36 range range VBP cord-014516-r59usk02 2344 37 5 5 CD cord-014516-r59usk02 2344 38 - - SYM cord-014516-r59usk02 2344 39 14 14 CD cord-014516-r59usk02 2344 40 ) ) -RRB- cord-014516-r59usk02 2344 41 , , , cord-014516-r59usk02 2344 42 18 18 CD cord-014516-r59usk02 2344 43 healthy healthy JJ cord-014516-r59usk02 2344 44 WHWT WHWT NNS cord-014516-r59usk02 2344 45 ( ( -LRB- cord-014516-r59usk02 2344 46 9 9 CD cord-014516-r59usk02 2344 47 , , , cord-014516-r59usk02 2344 48 3 3 CD cord-014516-r59usk02 2344 49 - - SYM cord-014516-r59usk02 2344 50 17 17 CD cord-014516-r59usk02 2344 51 ) ) -RRB- cord-014516-r59usk02 2344 52 , , , cord-014516-r59usk02 2344 53 and and CC cord-014516-r59usk02 2344 54 85 85 CD cord-014516-r59usk02 2344 55 healthy healthy JJ cord-014516-r59usk02 2344 56 dogs dog NNS cord-014516-r59usk02 2344 57 of of IN cord-014516-r59usk02 2344 58 other other JJ cord-014516-r59usk02 2344 59 breeds breed NNS cord-014516-r59usk02 2344 60 , , , cord-014516-r59usk02 2344 61 including include VBG cord-014516-r59usk02 2344 62 : : : cord-014516-r59usk02 2344 63 14 14 CD cord-014516-r59usk02 2344 64 Scottish scottish JJ cord-014516-r59usk02 2344 65 terrier terrier NN cord-014516-r59usk02 2344 66 ( ( -LRB- cord-014516-r59usk02 2344 67 ST ST NNP cord-014516-r59usk02 2344 68 ) ) -RRB- cord-014516-r59usk02 2344 69 ( ( -LRB- cord-014516-r59usk02 2344 70 5 5 CD cord-014516-r59usk02 2344 71 , , , cord-014516-r59usk02 2344 72 1 1 CD cord-014516-r59usk02 2344 73 - - SYM cord-014516-r59usk02 2344 74 10 10 CD cord-014516-r59usk02 2344 75 ) ) -RRB- cord-014516-r59usk02 2344 76 , , , cord-014516-r59usk02 2344 77 16 16 CD cord-014516-r59usk02 2344 78 Jack Jack NNP cord-014516-r59usk02 2344 79 Russell Russell NNP cord-014516-r59usk02 2344 80 terrier terrier NN cord-014516-r59usk02 2344 81 ( ( -LRB- cord-014516-r59usk02 2344 82 JRT JRT NNP cord-014516-r59usk02 2344 83 ) ) -RRB- cord-014516-r59usk02 2344 84 ( ( -LRB- cord-014516-r59usk02 2344 85 7 7 CD cord-014516-r59usk02 2344 86 , , , cord-014516-r59usk02 2344 87 1 1 CD cord-014516-r59usk02 2344 88 - - SYM cord-014516-r59usk02 2344 89 12 12 CD cord-014516-r59usk02 2344 90 ) ) -RRB- cord-014516-r59usk02 2344 91 , , , cord-014516-r59usk02 2344 92 15 15 CD cord-014516-r59usk02 2344 93 Maltese Maltese NNP cord-014516-r59usk02 2344 94 ( ( -LRB- cord-014516-r59usk02 2344 95 6 6 CD cord-014516-r59usk02 2344 96 , , , cord-014516-r59usk02 2344 97 1 1 CD cord-014516-r59usk02 2344 98 - - SYM cord-014516-r59usk02 2344 99 13 13 CD cord-014516-r59usk02 2344 100 ) ) -RRB- cord-014516-r59usk02 2344 101 , , , cord-014516-r59usk02 2344 102 14 14 CD cord-014516-r59usk02 2344 103 King King NNP cord-014516-r59usk02 2344 104 Charles Charles NNP cord-014516-r59usk02 2344 105 Spaniel Spaniel NNP cord-014516-r59usk02 2344 106 ( ( -LRB- cord-014516-r59usk02 2344 107 KCS KCS NNP cord-014516-r59usk02 2344 108 ) ) -RRB- cord-014516-r59usk02 2344 109 ( ( -LRB- cord-014516-r59usk02 2344 110 6 6 CD cord-014516-r59usk02 2344 111 , , , cord-014516-r59usk02 2344 112 1 1 CD cord-014516-r59usk02 2344 113 - - SYM cord-014516-r59usk02 2344 114 10 10 CD cord-014516-r59usk02 2344 115 ) ) -RRB- cord-014516-r59usk02 2344 116 , , , cord-014516-r59usk02 2344 117 12 12 CD cord-014516-r59usk02 2344 118 Labrador Labrador NNP cord-014516-r59usk02 2344 119 Retriever Retriever NNP cord-014516-r59usk02 2344 120 ( ( -LRB- cord-014516-r59usk02 2344 121 LR LR NNP cord-014516-r59usk02 2344 122 ) ) -RRB- cord-014516-r59usk02 2344 123 ( ( -LRB- cord-014516-r59usk02 2344 124 6 6 CD cord-014516-r59usk02 2344 125 , , , cord-014516-r59usk02 2344 126 2 2 CD cord-014516-r59usk02 2344 127 - - SYM cord-014516-r59usk02 2344 128 12 12 CD cord-014516-r59usk02 2344 129 ) ) -RRB- cord-014516-r59usk02 2344 130 and and CC cord-014516-r59usk02 2344 131 14 14 CD cord-014516-r59usk02 2344 132 Malinois malinois JJ cord-014516-r59usk02 2344 133 Belgian belgian JJ cord-014516-r59usk02 2344 134 Shepherd Shepherd NNP cord-014516-r59usk02 2344 135 ( ( -LRB- cord-014516-r59usk02 2344 136 6 6 CD cord-014516-r59usk02 2344 137 , , , cord-014516-r59usk02 2344 138 2 2 CD cord-014516-r59usk02 2344 139 - - SYM cord-014516-r59usk02 2344 140 8 8 CD cord-014516-r59usk02 2344 141 ) ) -RRB- cord-014516-r59usk02 2344 142 . . . cord-014516-r59usk02 2345 1 Health health NN cord-014516-r59usk02 2345 2 status status NN cord-014516-r59usk02 2345 3 was be VBD cord-014516-r59usk02 2345 4 based base VBN cord-014516-r59usk02 2345 5 on on IN cord-014516-r59usk02 2345 6 clinical clinical JJ cord-014516-r59usk02 2345 7 examination examination NN cord-014516-r59usk02 2345 8 , , , cord-014516-r59usk02 2345 9 serum serum NN cord-014516-r59usk02 2345 10 biochemistry biochemistry NN cord-014516-r59usk02 2345 11 and and CC cord-014516-r59usk02 2345 12 haematology haematology NN cord-014516-r59usk02 2345 13 in in IN cord-014516-r59usk02 2345 14 all all DT cord-014516-r59usk02 2345 15 healthy healthy JJ cord-014516-r59usk02 2345 16 dogs dog NNS cord-014516-r59usk02 2345 17 and and CC cord-014516-r59usk02 2345 18 a a DT cord-014516-r59usk02 2345 19 thoracic thoracic JJ cord-014516-r59usk02 2345 20 HRCT HRCT NNP cord-014516-r59usk02 2345 21 was be VBD cord-014516-r59usk02 2345 22 performed perform VBN cord-014516-r59usk02 2345 23 in in IN cord-014516-r59usk02 2345 24 9/18 9/18 CD cord-014516-r59usk02 2345 25 healthy healthy JJ cord-014516-r59usk02 2345 26 WHWT WHWT NNS cord-014516-r59usk02 2345 27 . . . cord-014516-r59usk02 2346 1 The the DT cord-014516-r59usk02 2346 2 Khi² Khi² NNP cord-014516-r59usk02 2346 3 test test NN cord-014516-r59usk02 2346 4 with with IN cord-014516-r59usk02 2346 5 the the DT cord-014516-r59usk02 2346 6 threshold threshold NN cord-014516-r59usk02 2346 7 5 5 CD cord-014516-r59usk02 2346 8 % % NN cord-014516-r59usk02 2346 9 was be VBD cord-014516-r59usk02 2346 10 used use VBN cord-014516-r59usk02 2346 11 for for IN cord-014516-r59usk02 2346 12 the the DT cord-014516-r59usk02 2346 13 statistical statistical JJ cord-014516-r59usk02 2346 14 analysis analysis NN cord-014516-r59usk02 2346 15 ( ( -LRB- cord-014516-r59usk02 2346 16 XLStat XLStat NNP cord-014516-r59usk02 2346 17 â â NNP cord-014516-r59usk02 2346 18 software software NN cord-014516-r59usk02 2346 19 ) ) -RRB- cord-014516-r59usk02 2346 20 . . . cord-014516-r59usk02 2347 1 Eight eight CD cord-014516-r59usk02 2347 2 CIPF CIPF NNP cord-014516-r59usk02 2347 3 WHWT WHWT NNS cord-014516-r59usk02 2347 4 ( ( -LRB- cord-014516-r59usk02 2347 5 57 57 CD cord-014516-r59usk02 2347 6 % % NN cord-014516-r59usk02 2347 7 ) ) -RRB- cord-014516-r59usk02 2347 8 have have VBP cord-014516-r59usk02 2347 9 serum serum NN cord-014516-r59usk02 2347 10 VEGF vegf NN cord-014516-r59usk02 2347 11 concentrations concentration NNS cord-014516-r59usk02 2347 12 above above IN cord-014516-r59usk02 2347 13 the the DT cord-014516-r59usk02 2347 14 kit kit NN cord-014516-r59usk02 2347 15 detection detection NN cord-014516-r59usk02 2347 16 limit limit NN cord-014516-r59usk02 2347 17 ( ( -LRB- cord-014516-r59usk02 2347 18 39.1 39.1 CD cord-014516-r59usk02 2347 19 pg pg NN cord-014516-r59usk02 2347 20 / / SYM cord-014516-r59usk02 2347 21 ml ml NN cord-014516-r59usk02 2347 22 ) ) -RRB- cord-014516-r59usk02 2347 23 compared compare VBN cord-014516-r59usk02 2347 24 to to IN cord-014516-r59usk02 2347 25 1 1 CD cord-014516-r59usk02 2347 26 WHWT WHWT NNS cord-014516-r59usk02 2347 27 ( ( -LRB- cord-014516-r59usk02 2347 28 0.05 0.05 CD cord-014516-r59usk02 2347 29 % % NN cord-014516-r59usk02 2347 30 ) ) -RRB- cord-014516-r59usk02 2347 31 in in IN cord-014516-r59usk02 2347 32 the the DT cord-014516-r59usk02 2347 33 group group NN cord-014516-r59usk02 2347 34 of of IN cord-014516-r59usk02 2347 35 healthy healthy JJ cord-014516-r59usk02 2347 36 dogs dog NNS cord-014516-r59usk02 2347 37 ( ( -LRB- cord-014516-r59usk02 2347 38 P p NN cord-014516-r59usk02 2347 39 = = SYM cord-014516-r59usk02 2347 40 0.001 0.001 CD cord-014516-r59usk02 2347 41 ) ) -RRB- cord-014516-r59usk02 2347 42 . . . cord-014516-r59usk02 2348 1 Concerning concern VBG cord-014516-r59usk02 2348 2 inter inter JJ cord-014516-r59usk02 2348 3 - - JJ cord-014516-r59usk02 2348 4 breed breed JJ cord-014516-r59usk02 2348 5 differences difference NNS cord-014516-r59usk02 2348 6 in in IN cord-014516-r59usk02 2348 7 healthy healthy JJ cord-014516-r59usk02 2348 8 dogs dog NNS cord-014516-r59usk02 2348 9 , , , cord-014516-r59usk02 2348 10 most most JJS cord-014516-r59usk02 2348 11 values value NNS cord-014516-r59usk02 2348 12 obtained obtain VBN cord-014516-r59usk02 2348 13 were be VBD cord-014516-r59usk02 2348 14 below below IN cord-014516-r59usk02 2348 15 the the DT cord-014516-r59usk02 2348 16 kit kit NN cord-014516-r59usk02 2348 17 detection detection NN cord-014516-r59usk02 2348 18 limit limit NN cord-014516-r59usk02 2348 19 with with IN cord-014516-r59usk02 2348 20 only only RB cord-014516-r59usk02 2348 21 3 3 CD cord-014516-r59usk02 2348 22 KCS KCS NNP cord-014516-r59usk02 2348 23 ( ( -LRB- cord-014516-r59usk02 2348 24 21 21 CD cord-014516-r59usk02 2348 25 % % NN cord-014516-r59usk02 2348 26 ) ) -RRB- cord-014516-r59usk02 2348 27 , , , cord-014516-r59usk02 2348 28 3 3 CD cord-014516-r59usk02 2348 29 JRT JRT NNP cord-014516-r59usk02 2348 30 ( ( -LRB- cord-014516-r59usk02 2348 31 19 19 CD cord-014516-r59usk02 2348 32 % % NN cord-014516-r59usk02 2348 33 ) ) -RRB- cord-014516-r59usk02 2348 34 , , , cord-014516-r59usk02 2348 35 3 3 CD cord-014516-r59usk02 2348 36 LR LR NNP cord-014516-r59usk02 2348 37 ( ( -LRB- cord-014516-r59usk02 2348 38 25 25 CD cord-014516-r59usk02 2348 39 % % NN cord-014516-r59usk02 2348 40 ) ) -RRB- cord-014516-r59usk02 2348 41 and and CC cord-014516-r59usk02 2348 42 1 1 CD cord-014516-r59usk02 2348 43 ST ST NNP cord-014516-r59usk02 2348 44 ( ( -LRB- cord-014516-r59usk02 2348 45 7 7 CD cord-014516-r59usk02 2348 46 % % NN cord-014516-r59usk02 2348 47 ) ) -RRB- cord-014516-r59usk02 2348 48 having have VBG cord-014516-r59usk02 2348 49 VEGF VEGF NNP cord-014516-r59usk02 2348 50 serum serum NN cord-014516-r59usk02 2348 51 levels level NNS cord-014516-r59usk02 2348 52 above above IN cord-014516-r59usk02 2348 53 39.1 39.1 CD cord-014516-r59usk02 2348 54 pg pg NN cord-014516-r59usk02 2348 55 / / SYM cord-014516-r59usk02 2348 56 ml ml NN cord-014516-r59usk02 2349 1 ( ( -LRB- cord-014516-r59usk02 2349 2 P p NN cord-014516-r59usk02 2349 3 = = SYM cord-014516-r59usk02 2349 4 0.147 0.147 CD cord-014516-r59usk02 2349 5 ) ) -RRB- cord-014516-r59usk02 2350 1 . . . cord-014516-r59usk02 2351 1 Results result NNS cord-014516-r59usk02 2351 2 of of IN cord-014516-r59usk02 2351 3 the the DT cord-014516-r59usk02 2351 4 present present JJ cord-014516-r59usk02 2351 5 study study NN cord-014516-r59usk02 2351 6 show show VBP cord-014516-r59usk02 2351 7 that that DT cord-014516-r59usk02 2352 1 ( ( -LRB- cord-014516-r59usk02 2352 2 1 1 LS cord-014516-r59usk02 2352 3 ) ) -RRB- cord-014516-r59usk02 2352 4 VEGF VEGF NNP cord-014516-r59usk02 2352 5 might may MD cord-014516-r59usk02 2352 6 be be VB cord-014516-r59usk02 2352 7 an an DT cord-014516-r59usk02 2352 8 interesting interesting JJ cord-014516-r59usk02 2352 9 blood blood NN cord-014516-r59usk02 2352 10 biomarker biomarker NN cord-014516-r59usk02 2352 11 for for IN cord-014516-r59usk02 2352 12 CIPF CIPF NNP cord-014516-r59usk02 2352 13 ; ; : cord-014516-r59usk02 2352 14 ( ( -LRB- cord-014516-r59usk02 2352 15 2 2 LS cord-014516-r59usk02 2352 16 ) ) -RRB- cord-014516-r59usk02 2352 17 canine canine JJ cord-014516-r59usk02 2352 18 VEGF VEGF NNP cord-014516-r59usk02 2352 19 Quantikine Quantikine NNP cord-014516-r59usk02 2352 20 Elisa Elisa NNP cord-014516-r59usk02 2352 21 kit kit NN cord-014516-r59usk02 2352 22 is be VBZ cord-014516-r59usk02 2352 23 not not RB cord-014516-r59usk02 2352 24 appropriate appropriate JJ cord-014516-r59usk02 2352 25 for for IN cord-014516-r59usk02 2352 26 measurement measurement NN cord-014516-r59usk02 2352 27 of of IN cord-014516-r59usk02 2352 28 serum serum NN cord-014516-r59usk02 2352 29 VEGF vegf NN cord-014516-r59usk02 2352 30 levels level NNS cord-014516-r59usk02 2352 31 in in IN cord-014516-r59usk02 2352 32 healthy healthy JJ cord-014516-r59usk02 2352 33 canine canine JJ cord-014516-r59usk02 2352 34 populations population NNS cord-014516-r59usk02 2352 35 . . . cord-014516-r59usk02 2353 1 No no DT cord-014516-r59usk02 2353 2 conflicts conflict NNS cord-014516-r59usk02 2353 3 of of IN cord-014516-r59usk02 2353 4 interest interest NN cord-014516-r59usk02 2353 5 reported report VBN cord-014516-r59usk02 2353 6 . . . cord-014516-r59usk02 2354 1 The the DT cord-014516-r59usk02 2354 2 total total JJ cord-014516-r59usk02 2354 3 protein protein NN cord-014516-r59usk02 2354 4 ( ( -LRB- cord-014516-r59usk02 2354 5 TP tp NN cord-014516-r59usk02 2354 6 ) ) -RRB- cord-014516-r59usk02 2354 7 concentration concentration NN cord-014516-r59usk02 2354 8 and and CC cord-014516-r59usk02 2354 9 cell cell NN cord-014516-r59usk02 2354 10 count count NN cord-014516-r59usk02 2354 11 of of IN cord-014516-r59usk02 2354 12 pleural pleural JJ cord-014516-r59usk02 2354 13 and and CC cord-014516-r59usk02 2354 14 abdominal abdominal JJ cord-014516-r59usk02 2354 15 fluid fluid NN cord-014516-r59usk02 2354 16 is be VBZ cord-014516-r59usk02 2354 17 used use VBN cord-014516-r59usk02 2354 18 to to TO cord-014516-r59usk02 2354 19 differentiate differentiate VB cord-014516-r59usk02 2354 20 a a DT cord-014516-r59usk02 2354 21 transudate transudate NN cord-014516-r59usk02 2354 22 from from IN cord-014516-r59usk02 2354 23 an an DT cord-014516-r59usk02 2354 24 exudate exudate NN cord-014516-r59usk02 2354 25 . . . cord-014516-r59usk02 2355 1 TP TP NNP cord-014516-r59usk02 2355 2 can can MD cord-014516-r59usk02 2355 3 be be VB cord-014516-r59usk02 2355 4 measured measure VBN cord-014516-r59usk02 2355 5 by by IN cord-014516-r59usk02 2355 6 automated automated JJ cord-014516-r59usk02 2355 7 wet wet JJ cord-014516-r59usk02 2355 8 chemistry chemistry NN cord-014516-r59usk02 2355 9 analyser analyser NN cord-014516-r59usk02 2355 10 or or CC cord-014516-r59usk02 2355 11 more more RBR cord-014516-r59usk02 2355 12 easily easily RB cord-014516-r59usk02 2355 13 using use VBG cord-014516-r59usk02 2355 14 a a DT cord-014516-r59usk02 2355 15 refractometer refractometer NN cord-014516-r59usk02 2355 16 . . . cord-014516-r59usk02 2356 1 The the DT cord-014516-r59usk02 2356 2 aim aim NN cord-014516-r59usk02 2356 3 of of IN cord-014516-r59usk02 2356 4 this this DT cord-014516-r59usk02 2356 5 study study NN cord-014516-r59usk02 2356 6 was be VBD cord-014516-r59usk02 2356 7 to to TO cord-014516-r59usk02 2356 8 assess assess VB cord-014516-r59usk02 2356 9 if if IN cord-014516-r59usk02 2356 10 refractometer refractometer NN cord-014516-r59usk02 2356 11 values value NNS cord-014516-r59usk02 2356 12 of of IN cord-014516-r59usk02 2356 13 TP TP NNP cord-014516-r59usk02 2356 14 are be VBP cord-014516-r59usk02 2356 15 useful useful JJ cord-014516-r59usk02 2356 16 for for IN cord-014516-r59usk02 2356 17 this this DT cord-014516-r59usk02 2356 18 purpose purpose NN cord-014516-r59usk02 2356 19 . . . cord-014516-r59usk02 2357 1 Retrospectively retrospectively RB cord-014516-r59usk02 2357 2 samples sample NNS cord-014516-r59usk02 2357 3 from from IN cord-014516-r59usk02 2357 4 canine canine JJ cord-014516-r59usk02 2357 5 pleural pleural JJ cord-014516-r59usk02 2357 6 and and CC cord-014516-r59usk02 2357 7 abdominal abdominal JJ cord-014516-r59usk02 2357 8 effusions effusion NNS cord-014516-r59usk02 2357 9 in in IN cord-014516-r59usk02 2357 10 which which WDT cord-014516-r59usk02 2357 11 TP tp NN cord-014516-r59usk02 2357 12 concentration concentration NN cord-014516-r59usk02 2357 13 was be VBD cord-014516-r59usk02 2357 14 measured measure VBN cord-014516-r59usk02 2357 15 both both CC cord-014516-r59usk02 2357 16 with with IN cord-014516-r59usk02 2357 17 a a DT cord-014516-r59usk02 2357 18 refractometer refractometer NN cord-014516-r59usk02 2357 19 as as RB cord-014516-r59usk02 2357 20 well well RB cord-014516-r59usk02 2357 21 using use VBG cord-014516-r59usk02 2357 22 Pentra Pentra NNP cord-014516-r59usk02 2357 23 400 400 CD cord-014516-r59usk02 2357 24 ( ( -LRB- cord-014516-r59usk02 2357 25 ABX ABX NNP cord-014516-r59usk02 2357 26 Horiba Horiba NNP cord-014516-r59usk02 2357 27 , , , cord-014516-r59usk02 2357 28 Montpellier Montpellier NNP cord-014516-r59usk02 2357 29 ) ) -RRB- cord-014516-r59usk02 2357 30 were be VBD cord-014516-r59usk02 2357 31 included include VBN cord-014516-r59usk02 2357 32 . . . cord-014516-r59usk02 2358 1 Samples sample NNS cord-014516-r59usk02 2358 2 were be VBD cord-014516-r59usk02 2358 3 collected collect VBN cord-014516-r59usk02 2358 4 into into IN cord-014516-r59usk02 2358 5 heparinized heparinize VBN cord-014516-r59usk02 2358 6 tubes tube NNS cord-014516-r59usk02 2358 7 and and CC cord-014516-r59usk02 2358 8 analysed analyse VBD cord-014516-r59usk02 2358 9 within within IN cord-014516-r59usk02 2358 10 12 12 CD cord-014516-r59usk02 2358 11 hours hour NNS cord-014516-r59usk02 2358 12 . . . cord-014516-r59usk02 2359 1 Bland Bland NNP cord-014516-r59usk02 2359 2 - - HYPH cord-014516-r59usk02 2359 3 Altman Altman NNP cord-014516-r59usk02 2359 4 diagrams diagram NNS cord-014516-r59usk02 2359 5 were be VBD cord-014516-r59usk02 2359 6 created create VBN cord-014516-r59usk02 2359 7 and and CC cord-014516-r59usk02 2359 8 correlation correlation NN cord-014516-r59usk02 2359 9 between between IN cord-014516-r59usk02 2359 10 both both DT cord-014516-r59usk02 2359 11 measurements measurement NNS cord-014516-r59usk02 2359 12 was be VBD cord-014516-r59usk02 2359 13 calculated calculate VBN cord-014516-r59usk02 2359 14 by by IN cord-014516-r59usk02 2359 15 Spearman Spearman NNP cord-014516-r59usk02 2359 16 0 0 NNP cord-014516-r59usk02 2359 17 s s NNP cord-014516-r59usk02 2359 18 nonparametric nonparametric JJ cord-014516-r59usk02 2359 19 correlation correlation NN cord-014516-r59usk02 2359 20 . . . cord-014516-r59usk02 2360 1 Over over IN cord-014516-r59usk02 2360 2 a a DT cord-014516-r59usk02 2360 3 48-months 48-months CD cord-014516-r59usk02 2360 4 period period NN cord-014516-r59usk02 2360 5 , , , cord-014516-r59usk02 2360 6 93 93 CD cord-014516-r59usk02 2360 7 pleural pleural NN cord-014516-r59usk02 2360 8 and and CC cord-014516-r59usk02 2360 9 147 147 CD cord-014516-r59usk02 2360 10 abdominal abdominal JJ cord-014516-r59usk02 2360 11 effusion effusion NN cord-014516-r59usk02 2360 12 samples sample NNS cord-014516-r59usk02 2360 13 were be VBD cord-014516-r59usk02 2360 14 analysed analyse VBN cord-014516-r59usk02 2360 15 with with IN cord-014516-r59usk02 2360 16 both both DT cord-014516-r59usk02 2360 17 techniques technique NNS cord-014516-r59usk02 2360 18 . . . cord-014516-r59usk02 2361 1 Median median JJ cord-014516-r59usk02 2361 2 ( ( -LRB- cord-014516-r59usk02 2361 3 range range NN cord-014516-r59usk02 2361 4 ) ) -RRB- cord-014516-r59usk02 2361 5 TP tp NN cord-014516-r59usk02 2361 6 concentrations concentration NNS cord-014516-r59usk02 2361 7 in in IN cord-014516-r59usk02 2361 8 pleural pleural JJ cord-014516-r59usk02 2361 9 effusion effusion NN cord-014516-r59usk02 2361 10 measured measure VBN cord-014516-r59usk02 2361 11 by by IN cord-014516-r59usk02 2361 12 refractormeter refractormeter NNP cord-014516-r59usk02 2361 13 or or CC cord-014516-r59usk02 2361 14 by by IN cord-014516-r59usk02 2361 15 Pentra Pentra NNP cord-014516-r59usk02 2361 16 was be VBD cord-014516-r59usk02 2361 17 33 33 CD cord-014516-r59usk02 2361 18 ( ( -LRB- cord-014516-r59usk02 2361 19 2 2 CD cord-014516-r59usk02 2361 20 - - SYM cord-014516-r59usk02 2361 21 57 57 CD cord-014516-r59usk02 2361 22 ) ) -RRB- cord-014516-r59usk02 2362 1 g g NNP cord-014516-r59usk02 2362 2 / / SYM cord-014516-r59usk02 2362 3 l l NN cord-014516-r59usk02 2362 4 and and CC cord-014516-r59usk02 2362 5 29 29 CD cord-014516-r59usk02 2362 6 ( ( -LRB- cord-014516-r59usk02 2362 7 7 7 CD cord-014516-r59usk02 2362 8 - - SYM cord-014516-r59usk02 2362 9 68 68 CD cord-014516-r59usk02 2362 10 ) ) -RRB- cord-014516-r59usk02 2362 11 g g NN cord-014516-r59usk02 2362 12 / / SYM cord-014516-r59usk02 2362 13 l l NN cord-014516-r59usk02 2362 14 , , , cord-014516-r59usk02 2362 15 respectively respectively RB cord-014516-r59usk02 2362 16 . . . cord-014516-r59usk02 2363 1 Median median JJ cord-014516-r59usk02 2363 2 ( ( -LRB- cord-014516-r59usk02 2363 3 range range NN cord-014516-r59usk02 2363 4 ) ) -RRB- cord-014516-r59usk02 2363 5 TP tp NN cord-014516-r59usk02 2363 6 concentrations concentration NNS cord-014516-r59usk02 2363 7 in in IN cord-014516-r59usk02 2363 8 abdominal abdominal JJ cord-014516-r59usk02 2363 9 effusions effusion NNS cord-014516-r59usk02 2363 10 measured measure VBN cord-014516-r59usk02 2363 11 by by IN cord-014516-r59usk02 2363 12 refractometer refractometer NN cord-014516-r59usk02 2363 13 or or CC cord-014516-r59usk02 2363 14 Pentra Pentra NNP cord-014516-r59usk02 2363 15 was be VBD cord-014516-r59usk02 2363 16 42 42 CD cord-014516-r59usk02 2363 17 ( ( -LRB- cord-014516-r59usk02 2363 18 2 2 CD cord-014516-r59usk02 2363 19 - - SYM cord-014516-r59usk02 2363 20 70 70 CD cord-014516-r59usk02 2363 21 ) ) -RRB- cord-014516-r59usk02 2363 22 g g NN cord-014516-r59usk02 2363 23 / / SYM cord-014516-r59usk02 2363 24 l l NN cord-014516-r59usk02 2363 25 and and CC cord-014516-r59usk02 2363 26 34 34 CD cord-014516-r59usk02 2363 27 ( ( -LRB- cord-014516-r59usk02 2363 28 2 2 CD cord-014516-r59usk02 2363 29 - - SYM cord-014516-r59usk02 2363 30 57 57 CD cord-014516-r59usk02 2363 31 ) ) -RRB- cord-014516-r59usk02 2363 32 g g NN cord-014516-r59usk02 2363 33 / / SYM cord-014516-r59usk02 2363 34 l l NN cord-014516-r59usk02 2363 35 , , , cord-014516-r59usk02 2363 36 respectively respectively RB cord-014516-r59usk02 2363 37 . . . cord-014516-r59usk02 2364 1 TP TP NNP cord-014516-r59usk02 2364 2 measurement measurement NN cord-014516-r59usk02 2364 3 between between IN cord-014516-r59usk02 2364 4 refractometer refractometer NN cord-014516-r59usk02 2364 5 and and CC cord-014516-r59usk02 2364 6 Pentra Pentra NNP cord-014516-r59usk02 2364 7 values value NNS cord-014516-r59usk02 2364 8 were be VBD cord-014516-r59usk02 2364 9 significantly significantly RB cord-014516-r59usk02 2364 10 correlated correlate VBN cord-014516-r59usk02 2364 11 in in IN cord-014516-r59usk02 2364 12 pleural pleural NN cord-014516-r59usk02 2364 13 ( ( -LRB- cord-014516-r59usk02 2364 14 r r NN cord-014516-r59usk02 2364 15 = = SYM cord-014516-r59usk02 2364 16 0.919 0.919 CD cord-014516-r59usk02 2364 17 , , , cord-014516-r59usk02 2364 18 P p NN cord-014516-r59usk02 2364 19 < < XX cord-014516-r59usk02 2364 20 0.0001 0.0001 CD cord-014516-r59usk02 2364 21 ) ) -RRB- cord-014516-r59usk02 2364 22 and and CC cord-014516-r59usk02 2364 23 abdominal abdominal JJ cord-014516-r59usk02 2364 24 ( ( -LRB- cord-014516-r59usk02 2364 25 r r NN cord-014516-r59usk02 2364 26 = = NN cord-014516-r59usk02 2364 27 0.907 0.907 CD cord-014516-r59usk02 2364 28 , , , cord-014516-r59usk02 2364 29 P p NN cord-014516-r59usk02 2364 30 < < XX cord-014516-r59usk02 2364 31 0.0001 0.0001 CD cord-014516-r59usk02 2364 32 ) ) -RRB- cord-014516-r59usk02 2364 33 effusion effusion NN cord-014516-r59usk02 2364 34 . . . cord-014516-r59usk02 2365 1 The the DT cord-014516-r59usk02 2365 2 Bland Bland NNP cord-014516-r59usk02 2365 3 - - HYPH cord-014516-r59usk02 2365 4 Altman Altman NNP cord-014516-r59usk02 2365 5 graph graph NN cord-014516-r59usk02 2365 6 showed show VBD cord-014516-r59usk02 2365 7 a a DT cord-014516-r59usk02 2365 8 bias bias NN cord-014516-r59usk02 2365 9 in in IN cord-014516-r59usk02 2365 10 the the DT cord-014516-r59usk02 2365 11 thorax thorax NN cord-014516-r59usk02 2365 12 and and CC cord-014516-r59usk02 2365 13 abdomen abdomen NN cord-014516-r59usk02 2365 14 of of IN cord-014516-r59usk02 2365 15 2.8 2.8 CD cord-014516-r59usk02 2365 16 and and CC cord-014516-r59usk02 2365 17 5.7 5.7 CD cord-014516-r59usk02 2365 18 . . . cord-014516-r59usk02 2366 1 The the DT cord-014516-r59usk02 2366 2 refractometer refractometer NN cord-014516-r59usk02 2366 3 is be VBZ cord-014516-r59usk02 2366 4 an an DT cord-014516-r59usk02 2366 5 acceptable acceptable JJ cord-014516-r59usk02 2366 6 , , , cord-014516-r59usk02 2366 7 rapid rapid JJ cord-014516-r59usk02 2366 8 and and CC cord-014516-r59usk02 2366 9 efficient efficient JJ cord-014516-r59usk02 2366 10 method method NN cord-014516-r59usk02 2366 11 for for IN cord-014516-r59usk02 2366 12 determination determination NN cord-014516-r59usk02 2366 13 of of IN cord-014516-r59usk02 2366 14 total total JJ cord-014516-r59usk02 2366 15 protein protein NN cord-014516-r59usk02 2366 16 concentration concentration NN cord-014516-r59usk02 2366 17 in in IN cord-014516-r59usk02 2366 18 pleural pleural JJ cord-014516-r59usk02 2366 19 and and CC cord-014516-r59usk02 2366 20 abdominal abdominal JJ cord-014516-r59usk02 2366 21 effusions effusion NNS cord-014516-r59usk02 2366 22 in in IN cord-014516-r59usk02 2366 23 dogs dog NNS cord-014516-r59usk02 2366 24 to to TO cord-014516-r59usk02 2366 25 differentiate differentiate VB cord-014516-r59usk02 2366 26 transudates transudate NNS cord-014516-r59usk02 2366 27 from from IN cord-014516-r59usk02 2366 28 exudates exudate NNS cord-014516-r59usk02 2366 29 . . . cord-014516-r59usk02 2367 1 No no DT cord-014516-r59usk02 2367 2 conflicts conflict NNS cord-014516-r59usk02 2367 3 of of IN cord-014516-r59usk02 2367 4 interest interest NN cord-014516-r59usk02 2367 5 reported report VBN cord-014516-r59usk02 2367 6 . . . cord-014516-r59usk02 2368 1 Coagulation coagulation NN cord-014516-r59usk02 2368 2 factor factor NN cord-014516-r59usk02 2368 3 VII VII NNP cord-014516-r59usk02 2368 4 ( ( -LRB- cord-014516-r59usk02 2368 5 FVII FVII NNP cord-014516-r59usk02 2368 6 ) ) -RRB- cord-014516-r59usk02 2368 7 deficiency deficiency NN cord-014516-r59usk02 2368 8 has have VBZ cord-014516-r59usk02 2368 9 been be VBN cord-014516-r59usk02 2368 10 reported report VBN cord-014516-r59usk02 2368 11 in in IN cord-014516-r59usk02 2368 12 Beagles beagle NNS cord-014516-r59usk02 2368 13 since since IN cord-014516-r59usk02 2368 14 the the DT cord-014516-r59usk02 2368 15 1960 1960 CD cord-014516-r59usk02 2368 16 's 's POS cord-014516-r59usk02 2368 17 . . . cord-014516-r59usk02 2369 1 Deficient deficient JJ cord-014516-r59usk02 2369 2 dogs dog NNS cord-014516-r59usk02 2369 3 show show VBP cord-014516-r59usk02 2369 4 a a DT cord-014516-r59usk02 2369 5 mild mild JJ cord-014516-r59usk02 2369 6 hemorrhagic hemorrhagic JJ cord-014516-r59usk02 2369 7 tendency tendency NN cord-014516-r59usk02 2369 8 , , , cord-014516-r59usk02 2369 9 but but CC cord-014516-r59usk02 2369 10 often often RB cord-014516-r59usk02 2369 11 remain remain VBP cord-014516-r59usk02 2369 12 asymptomatic asymptomatic JJ cord-014516-r59usk02 2369 13 and and CC cord-014516-r59usk02 2369 14 are be VBP cord-014516-r59usk02 2369 15 incidentally incidentally RB cord-014516-r59usk02 2369 16 discovered discover VBN cord-014516-r59usk02 2369 17 by by IN cord-014516-r59usk02 2369 18 an an DT cord-014516-r59usk02 2369 19 isolated isolated JJ cord-014516-r59usk02 2369 20 prolonged prolonged JJ cord-014516-r59usk02 2369 21 prothrombin prothrombin NN cord-014516-r59usk02 2369 22 time time NN cord-014516-r59usk02 2369 23 due due JJ cord-014516-r59usk02 2369 24 to to IN cord-014516-r59usk02 2369 25 < < XX cord-014516-r59usk02 2369 26 10 10 CD cord-014516-r59usk02 2369 27 % % NN cord-014516-r59usk02 2369 28 plasma plasma NN cord-014516-r59usk02 2369 29 FVII FVII NNP cord-014516-r59usk02 2369 30 activity activity NN cord-014516-r59usk02 2369 31 . . . cord-014516-r59usk02 2370 1 Factor factor NN cord-014516-r59usk02 2370 2 VII VII NNP cord-014516-r59usk02 2370 3 deficiency deficiency NN cord-014516-r59usk02 2370 4 occurs occur VBZ cord-014516-r59usk02 2370 5 commonly commonly RB cord-014516-r59usk02 2370 6 in in IN cord-014516-r59usk02 2370 7 Beagles Beagles NNPS cord-014516-r59usk02 2370 8 , , , cord-014516-r59usk02 2370 9 Alaskan Alaskan NNP cord-014516-r59usk02 2370 10 Klee Klee NNP cord-014516-r59usk02 2370 11 Kais Kais NNP cord-014516-r59usk02 2370 12 and and CC cord-014516-r59usk02 2370 13 Scottish Scottish NNP cord-014516-r59usk02 2370 14 Deerhounds Deerhounds NNPS cord-014516-r59usk02 2370 15 . . . cord-014516-r59usk02 2371 1 In in IN cord-014516-r59usk02 2371 2 these these DT cord-014516-r59usk02 2371 3 3 3 CD cord-014516-r59usk02 2371 4 breeds breed NNS cord-014516-r59usk02 2371 5 it -PRON- PRP cord-014516-r59usk02 2371 6 is be VBZ cord-014516-r59usk02 2371 7 caused cause VBN cord-014516-r59usk02 2371 8 by by IN cord-014516-r59usk02 2371 9 a a DT cord-014516-r59usk02 2371 10 single single JJ cord-014516-r59usk02 2371 11 missense missense JJ cord-014516-r59usk02 2371 12 mutation mutation NN cord-014516-r59usk02 2371 13 ( ( -LRB- cord-014516-r59usk02 2371 14 c.407 c.407 NN cord-014516-r59usk02 2371 15 G g NN cord-014516-r59usk02 2372 1 > > XX cord-014516-r59usk02 2373 1 A a NN cord-014516-r59usk02 2373 2 , , , cord-014516-r59usk02 2373 3 p. p. NN cord-014516-r59usk02 2374 1 Gly136Glu gly136glu LS cord-014516-r59usk02 2374 2 ) ) -RRB- cord-014516-r59usk02 2374 3 in in IN cord-014516-r59usk02 2374 4 the the DT cord-014516-r59usk02 2374 5 second second JJ cord-014516-r59usk02 2374 6 epidermal epidermal JJ cord-014516-r59usk02 2374 7 growth growth NN cord-014516-r59usk02 2374 8 factorlike factorlike NN cord-014516-r59usk02 2374 9 domain domain NN cord-014516-r59usk02 2374 10 of of IN cord-014516-r59usk02 2374 11 FVII FVII NNP cord-014516-r59usk02 2374 12 , , , cord-014516-r59usk02 2374 13 which which WDT cord-014516-r59usk02 2374 14 drastically drastically RB cord-014516-r59usk02 2374 15 reduces reduce VBZ cord-014516-r59usk02 2374 16 the the DT cord-014516-r59usk02 2374 17 secretion secretion NN cord-014516-r59usk02 2374 18 and and CC cord-014516-r59usk02 2374 19 activation activation NN cord-014516-r59usk02 2374 20 of of IN cord-014516-r59usk02 2374 21 FVII FVII NNP cord-014516-r59usk02 2374 22 . . . cord-014516-r59usk02 2375 1 Research research NN cord-014516-r59usk02 2375 2 beagles beagle NNS cord-014516-r59usk02 2375 3 were be VBD cord-014516-r59usk02 2375 4 also also RB cord-014516-r59usk02 2375 5 commonly commonly RB cord-014516-r59usk02 2375 6 affected affect VBN cord-014516-r59usk02 2375 7 which which WDT cord-014516-r59usk02 2375 8 may may MD cord-014516-r59usk02 2375 9 have have VB cord-014516-r59usk02 2375 10 pharmaco pharmaco NNP cord-014516-r59usk02 2375 11 - - HYPH cord-014516-r59usk02 2375 12 toxicologically toxicologically RB cord-014516-r59usk02 2375 13 affected affect VBN cord-014516-r59usk02 2375 14 studies study NNS cord-014516-r59usk02 2375 15 but but CC cord-014516-r59usk02 2375 16 specific specific JJ cord-014516-r59usk02 2375 17 DNA dna NN cord-014516-r59usk02 2375 18 screening screening NN cord-014516-r59usk02 2375 19 programs program NNS cord-014516-r59usk02 2375 20 have have VBP cord-014516-r59usk02 2375 21 been be VBN cord-014516-r59usk02 2375 22 established establish VBN cord-014516-r59usk02 2375 23 . . . cord-014516-r59usk02 2376 1 We -PRON- PRP cord-014516-r59usk02 2376 2 report report VBP cord-014516-r59usk02 2376 3 here here RB cord-014516-r59usk02 2376 4 on on IN cord-014516-r59usk02 2376 5 the the DT cord-014516-r59usk02 2376 6 discovery discovery NN cord-014516-r59usk02 2376 7 of of IN cord-014516-r59usk02 2376 8 FVII FVII NNP cord-014516-r59usk02 2376 9 deficiency deficiency NN cord-014516-r59usk02 2376 10 in in IN cord-014516-r59usk02 2376 11 Welsh Welsh NNP cord-014516-r59usk02 2376 12 Springer Springer NNP cord-014516-r59usk02 2376 13 Spaniels Spaniels NNPS cord-014516-r59usk02 2376 14 ( ( -LRB- cord-014516-r59usk02 2376 15 WSS WSS NNP cord-014516-r59usk02 2376 16 ) ) -RRB- cord-014516-r59usk02 2376 17 in in IN cord-014516-r59usk02 2376 18 Finland Finland NNP cord-014516-r59usk02 2376 19 based base VBN cord-014516-r59usk02 2376 20 upon upon IN cord-014516-r59usk02 2376 21 a a DT cord-014516-r59usk02 2376 22 novel novel JJ cord-014516-r59usk02 2376 23 screening screening NN cord-014516-r59usk02 2376 24 panel panel NN cord-014516-r59usk02 2376 25 for~100 for~100 NNS cord-014516-r59usk02 2376 26 known know VBN cord-014516-r59usk02 2376 27 mutations mutation NNS cord-014516-r59usk02 2376 28 underlying underlie VBG cord-014516-r59usk02 2376 29 inherited inherit VBN cord-014516-r59usk02 2376 30 disorders disorder NNS cord-014516-r59usk02 2376 31 in in IN cord-014516-r59usk02 2376 32 different different JJ cord-014516-r59usk02 2376 33 canine canine JJ cord-014516-r59usk02 2376 34 breeds breed NNS cord-014516-r59usk02 2376 35 ( ( -LRB- cord-014516-r59usk02 2376 36 www.mydogdna.com www.mydogdna.com ADD cord-014516-r59usk02 2376 37 ) ) -RRB- cord-014516-r59usk02 2376 38 . . . cord-014516-r59usk02 2377 1 Among among IN cord-014516-r59usk02 2377 2 31 31 CD cord-014516-r59usk02 2377 3 WSS WSS NNP cord-014516-r59usk02 2377 4 initially initially RB cord-014516-r59usk02 2377 5 tested test VBD cord-014516-r59usk02 2377 6 , , , cord-014516-r59usk02 2377 7 12 12 CD cord-014516-r59usk02 2377 8 were be VBD cord-014516-r59usk02 2377 9 heterozygously heterozygously NNP cord-014516-r59usk02 2377 10 ( ( -LRB- cord-014516-r59usk02 2377 11 39 39 CD cord-014516-r59usk02 2377 12 % % NN cord-014516-r59usk02 2377 13 ) ) -RRB- cord-014516-r59usk02 2377 14 , , , cord-014516-r59usk02 2377 15 and and CC cord-014516-r59usk02 2377 16 1 1 CD cord-014516-r59usk02 2377 17 homozygously homozygously NN cord-014516-r59usk02 2377 18 affected affect VBN cord-014516-r59usk02 2377 19 for for IN cord-014516-r59usk02 2377 20 the the DT cord-014516-r59usk02 2377 21 same same JJ cord-014516-r59usk02 2377 22 FVII FVII NNP cord-014516-r59usk02 2377 23 mutation mutation NN cord-014516-r59usk02 2377 24 , , , cord-014516-r59usk02 2377 25 which which WDT cord-014516-r59usk02 2377 26 was be VBD cord-014516-r59usk02 2377 27 confirmed confirm VBN cord-014516-r59usk02 2377 28 by by IN cord-014516-r59usk02 2377 29 sequencing sequence VBG cord-014516-r59usk02 2377 30 in in IN cord-014516-r59usk02 2377 31 all all DT cord-014516-r59usk02 2377 32 dogs dog NNS cord-014516-r59usk02 2377 33 . . . cord-014516-r59usk02 2378 1 In in IN cord-014516-r59usk02 2378 2 order order NN cord-014516-r59usk02 2378 3 to to TO cord-014516-r59usk02 2378 4 determine determine VB cord-014516-r59usk02 2378 5 whether whether IN cord-014516-r59usk02 2378 6 the the DT cord-014516-r59usk02 2378 7 mutation mutation NN cord-014516-r59usk02 2378 8 causes cause VBZ cord-014516-r59usk02 2378 9 FVII FVII NNP cord-014516-r59usk02 2378 10 deficiency deficiency NN cord-014516-r59usk02 2378 11 also also RB cord-014516-r59usk02 2378 12 in in IN cord-014516-r59usk02 2378 13 this this DT cord-014516-r59usk02 2378 14 breed breed NN cord-014516-r59usk02 2378 15 , , , cord-014516-r59usk02 2378 16 we -PRON- PRP cord-014516-r59usk02 2378 17 recruited recruit VBD cord-014516-r59usk02 2378 18 6 6 CD cord-014516-r59usk02 2378 19 littermates littermate NNS cord-014516-r59usk02 2378 20 and and CC cord-014516-r59usk02 2378 21 their -PRON- PRP$ cord-014516-r59usk02 2378 22 mother mother NN cord-014516-r59usk02 2378 23 . . . cord-014516-r59usk02 2379 1 None none NN cord-014516-r59usk02 2379 2 of of IN cord-014516-r59usk02 2379 3 these these DT cord-014516-r59usk02 2379 4 WSS WSS NNP cord-014516-r59usk02 2379 5 had have VBD cord-014516-r59usk02 2379 6 shown show VBN cord-014516-r59usk02 2379 7 an an DT cord-014516-r59usk02 2379 8 increased increase VBN cord-014516-r59usk02 2379 9 hemorrhagic hemorrhagic JJ cord-014516-r59usk02 2379 10 tendency tendency NN cord-014516-r59usk02 2379 11 , , , cord-014516-r59usk02 2379 12 but but CC cord-014516-r59usk02 2379 13 affecteds affecteds NNP cord-014516-r59usk02 2379 14 bled bleed VBD cord-014516-r59usk02 2379 15 excessively excessively RB cord-014516-r59usk02 2379 16 following follow VBG cord-014516-r59usk02 2379 17 blood blood NN cord-014516-r59usk02 2379 18 collection collection NN cord-014516-r59usk02 2379 19 . . . cord-014516-r59usk02 2380 1 We -PRON- PRP cord-014516-r59usk02 2380 2 found find VBD cord-014516-r59usk02 2380 3 that that IN cord-014516-r59usk02 2380 4 the the DT cord-014516-r59usk02 2380 5 3 3 CD cord-014516-r59usk02 2380 6 homozygous homozygous JJ cord-014516-r59usk02 2380 7 affected affect VBN cord-014516-r59usk02 2380 8 dogs dog NNS cord-014516-r59usk02 2380 9 of of IN cord-014516-r59usk02 2380 10 the the DT cord-014516-r59usk02 2380 11 litter litter NN cord-014516-r59usk02 2380 12 exhibited exhibit VBD cord-014516-r59usk02 2380 13 markedly markedly RB cord-014516-r59usk02 2380 14 prolonged prolong VBN cord-014516-r59usk02 2380 15 prothrombin prothrombin NN cord-014516-r59usk02 2380 16 time time NN cord-014516-r59usk02 2380 17 but but CC cord-014516-r59usk02 2380 18 normal normal JJ cord-014516-r59usk02 2380 19 partial partial JJ cord-014516-r59usk02 2380 20 thromboplastin thromboplastin NN cord-014516-r59usk02 2380 21 time time NN cord-014516-r59usk02 2380 22 . . . cord-014516-r59usk02 2381 1 They -PRON- PRP cord-014516-r59usk02 2381 2 also also RB cord-014516-r59usk02 2381 3 had have VBD cord-014516-r59usk02 2381 4 drastically drastically RB cord-014516-r59usk02 2381 5 reduced reduce VBN cord-014516-r59usk02 2381 6 FVII FVII NNP cord-014516-r59usk02 2381 7 activities activity NNS cord-014516-r59usk02 2381 8 but but CC cord-014516-r59usk02 2381 9 normal normal JJ cord-014516-r59usk02 2381 10 to to IN cord-014516-r59usk02 2381 11 high high JJ cord-014516-r59usk02 2381 12 FVIII FVIII NNS cord-014516-r59usk02 2381 13 and and CC cord-014516-r59usk02 2381 14 FIX fix VB cord-014516-r59usk02 2381 15 activities activity NNS cord-014516-r59usk02 2381 16 compared compare VBN cord-014516-r59usk02 2381 17 to to IN cord-014516-r59usk02 2381 18 their -PRON- PRP$ cord-014516-r59usk02 2381 19 littermate littermate NN cord-014516-r59usk02 2381 20 controls control NNS cord-014516-r59usk02 2381 21 . . . cord-014516-r59usk02 2382 1 The the DT cord-014516-r59usk02 2382 2 3 3 CD cord-014516-r59usk02 2382 3 heterozygous heterozygous JJ cord-014516-r59usk02 2382 4 carriers carrier NNS cord-014516-r59usk02 2382 5 tested test VBN cord-014516-r59usk02 2382 6 did do VBD cord-014516-r59usk02 2382 7 not not RB cord-014516-r59usk02 2382 8 show show VB cord-014516-r59usk02 2382 9 any any DT cord-014516-r59usk02 2382 10 prolongations prolongation NNS cord-014516-r59usk02 2382 11 in in IN cord-014516-r59usk02 2382 12 their -PRON- PRP$ cord-014516-r59usk02 2382 13 prothrombin prothrombin NN cord-014516-r59usk02 2382 14 time time NN cord-014516-r59usk02 2382 15 , , , cord-014516-r59usk02 2382 16 but but CC cord-014516-r59usk02 2382 17 had have VBD cord-014516-r59usk02 2382 18 half half DT cord-014516-r59usk02 2382 19 normal normal JJ cord-014516-r59usk02 2382 20 FVII FVII NNP cord-014516-r59usk02 2382 21 activity activity NN cord-014516-r59usk02 2382 22 . . . cord-014516-r59usk02 2383 1 In in IN cord-014516-r59usk02 2383 2 conclusion conclusion NN cord-014516-r59usk02 2383 3 , , , cord-014516-r59usk02 2383 4 we -PRON- PRP cord-014516-r59usk02 2383 5 document document VBP cord-014516-r59usk02 2383 6 here here RB cord-014516-r59usk02 2383 7 the the DT cord-014516-r59usk02 2383 8 presence presence NN cord-014516-r59usk02 2383 9 of of IN cord-014516-r59usk02 2383 10 FVII FVII NNP cord-014516-r59usk02 2383 11 deficiency deficiency NN cord-014516-r59usk02 2383 12 in in IN cord-014516-r59usk02 2383 13 WSS WSS NNP cord-014516-r59usk02 2383 14 based base VBN cord-014516-r59usk02 2383 15 upon upon IN cord-014516-r59usk02 2383 16 DNA dna NN cord-014516-r59usk02 2383 17 and and CC cord-014516-r59usk02 2383 18 coagulation coagulation NN cord-014516-r59usk02 2383 19 activity activity NN cord-014516-r59usk02 2383 20 testing testing NN cord-014516-r59usk02 2383 21 . . . cord-014516-r59usk02 2384 1 The the DT cord-014516-r59usk02 2384 2 common common JJ cord-014516-r59usk02 2384 3 Gly136Glu gly136glu JJ cord-014516-r59usk02 2384 4 mutation mutation NN cord-014516-r59usk02 2384 5 must must MD cord-014516-r59usk02 2384 6 have have VB cord-014516-r59usk02 2384 7 arisen arise VBN cord-014516-r59usk02 2384 8 prior prior RB cord-014516-r59usk02 2384 9 to to IN cord-014516-r59usk02 2384 10 the the DT cord-014516-r59usk02 2384 11 separation separation NN cord-014516-r59usk02 2384 12 of of IN cord-014516-r59usk02 2384 13 the the DT cord-014516-r59usk02 2384 14 very very RB cord-014516-r59usk02 2384 15 different different JJ cord-014516-r59usk02 2384 16 FVII FVII NNP cord-014516-r59usk02 2384 17 deficient deficient JJ cord-014516-r59usk02 2384 18 breeds breed NNS cord-014516-r59usk02 2384 19 . . . cord-014516-r59usk02 2385 1 There there EX cord-014516-r59usk02 2385 2 is be VBZ cord-014516-r59usk02 2385 3 no no DT cord-014516-r59usk02 2385 4 knowledge knowledge NN cord-014516-r59usk02 2385 5 of of IN cord-014516-r59usk02 2385 6 an an DT cord-014516-r59usk02 2385 7 advantage advantage NN cord-014516-r59usk02 2385 8 of of IN cord-014516-r59usk02 2385 9 the the DT cord-014516-r59usk02 2385 10 heterozygote heterozygote NN cord-014516-r59usk02 2385 11 state state NN cord-014516-r59usk02 2385 12 . . . cord-014516-r59usk02 2386 1 While while IN cord-014516-r59usk02 2386 2 there there EX cord-014516-r59usk02 2386 3 is be VBZ cord-014516-r59usk02 2386 4 only only RB cord-014516-r59usk02 2386 5 a a DT cord-014516-r59usk02 2386 6 mild mild JJ cord-014516-r59usk02 2386 7 hemorrhagic hemorrhagic JJ cord-014516-r59usk02 2386 8 tendency tendency NN cord-014516-r59usk02 2386 9 , , , cord-014516-r59usk02 2386 10 bleeding bleed VBG cord-014516-r59usk02 2386 11 dogs dog NNS cord-014516-r59usk02 2386 12 could could MD cord-014516-r59usk02 2386 13 be be VB cord-014516-r59usk02 2386 14 treated treat VBN cord-014516-r59usk02 2386 15 with with IN cord-014516-r59usk02 2386 16 fresh fresh JJ cord-014516-r59usk02 2386 17 frozen frozen JJ cord-014516-r59usk02 2386 18 or or CC cord-014516-r59usk02 2386 19 cryo cryo NN cord-014516-r59usk02 2386 20 - - HYPH cord-014516-r59usk02 2386 21 poor poor JJ cord-014516-r59usk02 2386 22 plasma plasma NN cord-014516-r59usk02 2386 23 or or CC cord-014516-r59usk02 2386 24 human human JJ cord-014516-r59usk02 2386 25 recombinant recombinant JJ cord-014516-r59usk02 2386 26 FVIIa FVIIa NNS cord-014516-r59usk02 2386 27 . . . cord-014516-r59usk02 2387 1 This this DT cord-014516-r59usk02 2387 2 preliminary preliminary JJ cord-014516-r59usk02 2387 3 study study NN cord-014516-r59usk02 2387 4 indicates indicate VBZ cord-014516-r59usk02 2387 5 a a DT cord-014516-r59usk02 2387 6 high high JJ cord-014516-r59usk02 2387 7 carrier carrier NN cord-014516-r59usk02 2387 8 frequency frequency NN cord-014516-r59usk02 2387 9 in in IN cord-014516-r59usk02 2387 10 WSS WSS NNP cord-014516-r59usk02 2387 11 . . . cord-014516-r59usk02 2388 1 Screening screening NN cord-014516-r59usk02 2388 2 by by IN cord-014516-r59usk02 2388 3 new new JJ cord-014516-r59usk02 2388 4 platform platform NN cord-014516-r59usk02 2388 5 DNA dna NN cord-014516-r59usk02 2388 6 methods method NNS cord-014516-r59usk02 2388 7 for for IN cord-014516-r59usk02 2388 8 this this DT cord-014516-r59usk02 2388 9 and and CC cord-014516-r59usk02 2388 10 other other JJ cord-014516-r59usk02 2388 11 ancestral ancestral JJ cord-014516-r59usk02 2388 12 defects defect NNS cord-014516-r59usk02 2388 13 is be VBZ cord-014516-r59usk02 2388 14 helpful helpful JJ cord-014516-r59usk02 2388 15 to to TO cord-014516-r59usk02 2388 16 detect detect VB cord-014516-r59usk02 2388 17 additional additional JJ cord-014516-r59usk02 2388 18 hereditary hereditary JJ cord-014516-r59usk02 2388 19 diseases disease NNS cord-014516-r59usk02 2388 20 and and CC cord-014516-r59usk02 2388 21 genetic genetic JJ cord-014516-r59usk02 2388 22 predispositions predisposition NNS cord-014516-r59usk02 2388 23 in in IN cord-014516-r59usk02 2388 24 different different JJ cord-014516-r59usk02 2388 25 breeds breed NNS cord-014516-r59usk02 2388 26 , , , cord-014516-r59usk02 2388 27 while while IN cord-014516-r59usk02 2388 28 other other JJ cord-014516-r59usk02 2388 29 mutations mutation NNS cord-014516-r59usk02 2388 30 are be VBP cord-014516-r59usk02 2388 31 new new JJ cord-014516-r59usk02 2388 32 and and CC cord-014516-r59usk02 2388 33 restricted restrict VBN cord-014516-r59usk02 2388 34 to to IN cord-014516-r59usk02 2388 35 one one CD cord-014516-r59usk02 2388 36 or or CC cord-014516-r59usk02 2388 37 related related JJ cord-014516-r59usk02 2388 38 breeds breed NNS cord-014516-r59usk02 2388 39 . . . cord-014516-r59usk02 2389 1 Authors author NNS cord-014516-r59usk02 2389 2 are be VBP cord-014516-r59usk02 2389 3 affiliated affiliate VBN cord-014516-r59usk02 2389 4 with with IN cord-014516-r59usk02 2389 5 genetic genetic JJ cord-014516-r59usk02 2389 6 disease disease NN cord-014516-r59usk02 2389 7 screening screening NN cord-014516-r59usk02 2389 8 test test NN cord-014516-r59usk02 2389 9 laboratory laboratory NN cord-014516-r59usk02 2389 10 . . . cord-014516-r59usk02 2390 1 Remarkably remarkably RB cord-014516-r59usk02 2390 2 little little JJ cord-014516-r59usk02 2390 3 has have VBZ cord-014516-r59usk02 2390 4 been be VBN cord-014516-r59usk02 2390 5 published publish VBN cord-014516-r59usk02 2390 6 on on IN cord-014516-r59usk02 2390 7 haematological haematological NN cord-014516-r59usk02 2390 8 and and CC cord-014516-r59usk02 2390 9 serum serum JJ cord-014516-r59usk02 2390 10 biochemical biochemical JJ cord-014516-r59usk02 2390 11 phenotypes phenotype NNS cord-014516-r59usk02 2390 12 of of IN cord-014516-r59usk02 2390 13 the the DT cord-014516-r59usk02 2390 14 domestic domestic JJ cord-014516-r59usk02 2390 15 dog dog NN cord-014516-r59usk02 2390 16 . . . cord-014516-r59usk02 2391 1 Information information NN cord-014516-r59usk02 2391 2 on on IN cord-014516-r59usk02 2391 3 the the DT cord-014516-r59usk02 2391 4 signalment signalment JJ cord-014516-r59usk02 2391 5 and and CC cord-014516-r59usk02 2391 6 complete complete JJ cord-014516-r59usk02 2391 7 blood blood NN cord-014516-r59usk02 2391 8 cell cell NN cord-014516-r59usk02 2391 9 count count NN cord-014516-r59usk02 2391 10 of of IN cord-014516-r59usk02 2391 11 all all DT cord-014516-r59usk02 2391 12 dogs dog NNS cord-014516-r59usk02 2391 13 with with IN cord-014516-r59usk02 2391 14 normal normal JJ cord-014516-r59usk02 2391 15 red red JJ cord-014516-r59usk02 2391 16 and and CC cord-014516-r59usk02 2391 17 white white JJ cord-014516-r59usk02 2391 18 blood blood NN cord-014516-r59usk02 2391 19 cell cell NN cord-014516-r59usk02 2391 20 parameters parameter NNS cord-014516-r59usk02 2391 21 judged judge VBN cord-014516-r59usk02 2391 22 by by IN cord-014516-r59usk02 2391 23 existing exist VBG cord-014516-r59usk02 2391 24 reference reference NN cord-014516-r59usk02 2391 25 intervals interval NNS cord-014516-r59usk02 2391 26 was be VBD cord-014516-r59usk02 2391 27 extracted extract VBN cord-014516-r59usk02 2391 28 from from IN cord-014516-r59usk02 2391 29 a a DT cord-014516-r59usk02 2391 30 veterinary veterinary JJ cord-014516-r59usk02 2391 31 database database NN cord-014516-r59usk02 2391 32 ; ; , cord-014516-r59usk02 2391 33 similar similar JJ cord-014516-r59usk02 2391 34 information information NN cord-014516-r59usk02 2391 35 was be VBD cord-014516-r59usk02 2391 36 collected collect VBN cord-014516-r59usk02 2391 37 from from IN cord-014516-r59usk02 2391 38 all all DT cord-014516-r59usk02 2391 39 dogs dog NNS cord-014516-r59usk02 2391 40 with with IN cord-014516-r59usk02 2391 41 normal normal JJ cord-014516-r59usk02 2391 42 serum serum NN cord-014516-r59usk02 2391 43 biochemical biochemical JJ cord-014516-r59usk02 2391 44 profiles profile NNS cord-014516-r59usk02 2391 45 , , , cord-014516-r59usk02 2391 46 considering consider VBG cord-014516-r59usk02 2391 47 all all DT cord-014516-r59usk02 2391 48 parameters parameter NNS cord-014516-r59usk02 2391 49 other other JJ cord-014516-r59usk02 2391 50 than than IN cord-014516-r59usk02 2391 51 glucose glucose NN cord-014516-r59usk02 2391 52 as as IN cord-014516-r59usk02 2391 53 inclusion inclusion NN cord-014516-r59usk02 2391 54 criteria criterion NNS cord-014516-r59usk02 2391 55 . . . cord-014516-r59usk02 2392 1 Normal normal JJ cord-014516-r59usk02 2392 2 haematological haematological JJ cord-014516-r59usk02 2392 3 profiles profile NNS cord-014516-r59usk02 2392 4 were be VBD cord-014516-r59usk02 2392 5 available available JJ cord-014516-r59usk02 2392 6 for for IN cord-014516-r59usk02 2392 7 6046 6046 CD cord-014516-r59usk02 2392 8 dogs dog NNS cord-014516-r59usk02 2392 9 , , , cord-014516-r59usk02 2392 10 5447 5447 CD cord-014516-r59usk02 2392 11 of of IN cord-014516-r59usk02 2392 12 which which WDT cord-014516-r59usk02 2392 13 also also RB cord-014516-r59usk02 2392 14 had have VBD cord-014516-r59usk02 2392 15 machine machine NN cord-014516-r59usk02 2392 16 platelet platelet NN cord-014516-r59usk02 2392 17 concentrations concentration NNS cord-014516-r59usk02 2392 18 within within IN cord-014516-r59usk02 2392 19 the the DT cord-014516-r59usk02 2392 20 reference reference NN cord-014516-r59usk02 2392 21 interval interval NN cord-014516-r59usk02 2392 22 ; ; : cord-014516-r59usk02 2392 23 normal normal JJ cord-014516-r59usk02 2392 24 serum serum NN cord-014516-r59usk02 2392 25 biochemical biochemical JJ cord-014516-r59usk02 2392 26 profiles profile NNS cord-014516-r59usk02 2392 27 were be VBD cord-014516-r59usk02 2392 28 available available JJ cord-014516-r59usk02 2392 29 from from IN cord-014516-r59usk02 2392 30 3045 3045 CD cord-014516-r59usk02 2392 31 dogs dog NNS cord-014516-r59usk02 2392 32 , , , cord-014516-r59usk02 2392 33 1495 1495 CD cord-014516-r59usk02 2392 34 of of IN cord-014516-r59usk02 2392 35 which which WDT cord-014516-r59usk02 2392 36 also also RB cord-014516-r59usk02 2392 37 had have VBD cord-014516-r59usk02 2392 38 accompanying accompany VBG cord-014516-r59usk02 2392 39 normal normal JJ cord-014516-r59usk02 2392 40 serum serum NN cord-014516-r59usk02 2392 41 glucose glucose NN cord-014516-r59usk02 2392 42 concentrations concentration NNS cord-014516-r59usk02 2392 43 . . . cord-014516-r59usk02 2393 1 For for IN cord-014516-r59usk02 2393 2 the the DT cord-014516-r59usk02 2393 3 haematological haematological JJ cord-014516-r59usk02 2393 4 data datum NNS cord-014516-r59usk02 2393 5 , , , cord-014516-r59usk02 2393 6 75 75 CD cord-014516-r59usk02 2393 7 pure pure JJ cord-014516-r59usk02 2393 8 breeds breed NNS cord-014516-r59usk02 2393 9 plus plus CC cord-014516-r59usk02 2393 10 a a DT cord-014516-r59usk02 2393 11 mixed mixed JJ cord-014516-r59usk02 2393 12 breed breed NN cord-014516-r59usk02 2393 13 control control NN cord-014516-r59usk02 2393 14 group group NN cord-014516-r59usk02 2393 15 were be VBD cord-014516-r59usk02 2393 16 represented represent VBN cord-014516-r59usk02 2393 17 by by IN cord-014516-r59usk02 2393 18 10 10 CD cord-014516-r59usk02 2393 19 or or CC cord-014516-r59usk02 2393 20 more more JJR cord-014516-r59usk02 2393 21 dogs dog NNS cord-014516-r59usk02 2393 22 , , , cord-014516-r59usk02 2393 23 while while IN cord-014516-r59usk02 2393 24 for for IN cord-014516-r59usk02 2393 25 the the DT cord-014516-r59usk02 2393 26 serum serum NN cord-014516-r59usk02 2393 27 biochemical biochemical JJ cord-014516-r59usk02 2393 28 data datum NNS cord-014516-r59usk02 2393 29 , , , cord-014516-r59usk02 2393 30 60 60 CD cord-014516-r59usk02 2393 31 pure pure JJ cord-014516-r59usk02 2393 32 breeds breed NNS cord-014516-r59usk02 2393 33 plus plus CC cord-014516-r59usk02 2393 34 a a DT cord-014516-r59usk02 2393 35 mixed mixed JJ cord-014516-r59usk02 2393 36 breed breed NN cord-014516-r59usk02 2393 37 control control NN cord-014516-r59usk02 2393 38 group group NN cord-014516-r59usk02 2393 39 were be VBD cord-014516-r59usk02 2393 40 represented represent VBN cord-014516-r59usk02 2393 41 by by IN cord-014516-r59usk02 2393 42 10 10 CD cord-014516-r59usk02 2393 43 or or CC cord-014516-r59usk02 2393 44 more more JJR cord-014516-r59usk02 2393 45 individuals individual NNS cord-014516-r59usk02 2393 46 . . . cord-014516-r59usk02 2394 1 All all DT cord-014516-r59usk02 2394 2 measured measure VBN cord-014516-r59usk02 2394 3 haematological haematological NN cord-014516-r59usk02 2394 4 parameters parameter NNS cord-014516-r59usk02 2394 5 except except IN cord-014516-r59usk02 2394 6 mean mean VB cord-014516-r59usk02 2394 7 corpuscular corpuscular JJ cord-014516-r59usk02 2394 8 haemoglobin haemoglobin NN cord-014516-r59usk02 2394 9 concentration concentration NN cord-014516-r59usk02 2394 10 ( ( -LRB- cord-014516-r59usk02 2394 11 MCHC MCHC NNP cord-014516-r59usk02 2394 12 ) ) -RRB- cord-014516-r59usk02 2394 13 , , , cord-014516-r59usk02 2394 14 and and CC cord-014516-r59usk02 2394 15 all all DT cord-014516-r59usk02 2394 16 serum serum NN cord-014516-r59usk02 2394 17 biochemical biochemical JJ cord-014516-r59usk02 2394 18 analytes analyte NNS cord-014516-r59usk02 2394 19 except except IN cord-014516-r59usk02 2394 20 sodium sodium NN cord-014516-r59usk02 2394 21 , , , cord-014516-r59usk02 2394 22 chloride chloride NN cord-014516-r59usk02 2394 23 and and CC cord-014516-r59usk02 2394 24 glucose glucose NN cord-014516-r59usk02 2394 25 , , , cord-014516-r59usk02 2394 26 varied varied JJ cord-014516-r59usk02 2394 27 with with IN cord-014516-r59usk02 2394 28 age age NN cord-014516-r59usk02 2394 29 . . . cord-014516-r59usk02 2395 1 Concentrations concentration NNS cord-014516-r59usk02 2395 2 of of IN cord-014516-r59usk02 2395 3 white white JJ cord-014516-r59usk02 2395 4 blood blood NN cord-014516-r59usk02 2395 5 cells cell NNS cord-014516-r59usk02 2395 6 ( ( -LRB- cord-014516-r59usk02 2395 7 WBCs WBCs NNP cord-014516-r59usk02 2395 8 ) ) -RRB- cord-014516-r59usk02 2395 9 , , , cord-014516-r59usk02 2395 10 neutrophils neutrophil NNS cord-014516-r59usk02 2395 11 , , , cord-014516-r59usk02 2395 12 monocytes monocyte NNS cord-014516-r59usk02 2395 13 , , , cord-014516-r59usk02 2395 14 lymphocytes lymphocyte NNS cord-014516-r59usk02 2395 15 , , , cord-014516-r59usk02 2395 16 eosinophils eosinophil NNS cord-014516-r59usk02 2395 17 and and CC cord-014516-r59usk02 2395 18 platelets platelet NNS cord-014516-r59usk02 2395 19 , , , cord-014516-r59usk02 2395 20 but but CC cord-014516-r59usk02 2395 21 not not RB cord-014516-r59usk02 2395 22 red red JJ cord-014516-r59usk02 2395 23 blood blood NN cord-014516-r59usk02 2395 24 cell cell NN cord-014516-r59usk02 2395 25 parameters parameter NNS cord-014516-r59usk02 2395 26 , , , cord-014516-r59usk02 2395 27 all all DT cord-014516-r59usk02 2395 28 varied varied JJ cord-014516-r59usk02 2395 29 with with IN cord-014516-r59usk02 2395 30 sex sex NN cord-014516-r59usk02 2395 31 , , , cord-014516-r59usk02 2395 32 as as IN cord-014516-r59usk02 2395 33 did do VBD cord-014516-r59usk02 2395 34 total total JJ cord-014516-r59usk02 2395 35 protein protein NN cord-014516-r59usk02 2395 36 , , , cord-014516-r59usk02 2395 37 globulin globulin NN cord-014516-r59usk02 2395 38 , , , cord-014516-r59usk02 2395 39 potassium potassium NN cord-014516-r59usk02 2395 40 , , , cord-014516-r59usk02 2395 41 chloride chloride NN cord-014516-r59usk02 2395 42 , , , cord-014516-r59usk02 2395 43 creatinine creatinine NN cord-014516-r59usk02 2395 44 , , , cord-014516-r59usk02 2395 45 cholesterol cholesterol NN cord-014516-r59usk02 2395 46 , , , cord-014516-r59usk02 2395 47 total total JJ cord-014516-r59usk02 2395 48 bilirubin bilirubin NN cord-014516-r59usk02 2395 49 , , , cord-014516-r59usk02 2395 50 and and CC cord-014516-r59usk02 2395 51 activities activity NNS cord-014516-r59usk02 2395 52 of of IN cord-014516-r59usk02 2395 53 alanine alanine JJ cord-014516-r59usk02 2395 54 aminotransferase aminotransferase NN cord-014516-r59usk02 2395 55 ( ( -LRB- cord-014516-r59usk02 2395 56 ALT ALT NNP cord-014516-r59usk02 2395 57 ) ) -RRB- cord-014516-r59usk02 2395 58 , , , cord-014516-r59usk02 2395 59 creatine creatine NN cord-014516-r59usk02 2395 60 kinase kinase NN cord-014516-r59usk02 2395 61 ( ( -LRB- cord-014516-r59usk02 2395 62 CK CK NNP cord-014516-r59usk02 2395 63 ) ) -RRB- cord-014516-r59usk02 2395 64 , , , cord-014516-r59usk02 2395 65 amylase amylase NN cord-014516-r59usk02 2395 66 and and CC cord-014516-r59usk02 2395 67 lipase lipase NN cord-014516-r59usk02 2395 68 . . . cord-014516-r59usk02 2396 1 Neutering neuter VBG cord-014516-r59usk02 2396 2 status status NN cord-014516-r59usk02 2396 3 had have VBD cord-014516-r59usk02 2396 4 an an DT cord-014516-r59usk02 2396 5 impact impact NN cord-014516-r59usk02 2396 6 on on IN cord-014516-r59usk02 2396 7 haemoglobin haemoglobin NN cord-014516-r59usk02 2396 8 concentration concentration NN cord-014516-r59usk02 2396 9 , , , cord-014516-r59usk02 2396 10 mean mean VB cord-014516-r59usk02 2396 11 corpuscular corpuscular JJ cord-014516-r59usk02 2396 12 haemoglobin haemoglobin NN cord-014516-r59usk02 2396 13 ( ( -LRB- cord-014516-r59usk02 2396 14 MCH MCH NNP cord-014516-r59usk02 2396 15 ) ) -RRB- cord-014516-r59usk02 2396 16 , , , cord-014516-r59usk02 2396 17 MCHC MCHC NNP cord-014516-r59usk02 2396 18 , , , cord-014516-r59usk02 2396 19 and and CC cord-014516-r59usk02 2396 20 concentrations concentration NNS cord-014516-r59usk02 2396 21 of of IN cord-014516-r59usk02 2396 22 WBCs wbc NNS cord-014516-r59usk02 2396 23 , , , cord-014516-r59usk02 2396 24 neutrophils neutrophil NNS cord-014516-r59usk02 2396 25 , , , cord-014516-r59usk02 2396 26 monocytes monocyte NNS cord-014516-r59usk02 2396 27 , , , cord-014516-r59usk02 2396 28 lymphocytes lymphocyte NNS cord-014516-r59usk02 2396 29 and and CC cord-014516-r59usk02 2396 30 platelets platelet NNS cord-014516-r59usk02 2396 31 , , , cord-014516-r59usk02 2396 32 as as RB cord-014516-r59usk02 2396 33 well well RB cord-014516-r59usk02 2396 34 as as IN cord-014516-r59usk02 2396 35 all all DT cord-014516-r59usk02 2396 36 serum serum NN cord-014516-r59usk02 2396 37 biochemical biochemical JJ cord-014516-r59usk02 2396 38 analytes analyte NNS cord-014516-r59usk02 2396 39 except except IN cord-014516-r59usk02 2396 40 albumin albumin NN cord-014516-r59usk02 2396 41 , , , cord-014516-r59usk02 2396 42 sodium sodium NN cord-014516-r59usk02 2396 43 , , , cord-014516-r59usk02 2396 44 calcium calcium NN cord-014516-r59usk02 2396 45 , , , cord-014516-r59usk02 2396 46 urea urea NN cord-014516-r59usk02 2396 47 and and CC cord-014516-r59usk02 2396 48 glucose glucose NN cord-014516-r59usk02 2396 49 . . . cord-014516-r59usk02 2397 1 Principal principal JJ cord-014516-r59usk02 2397 2 component component NN cord-014516-r59usk02 2397 3 analysis analysis NN cord-014516-r59usk02 2397 4 ( ( -LRB- cord-014516-r59usk02 2397 5 PCA PCA NNP cord-014516-r59usk02 2397 6 ) ) -RRB- cord-014516-r59usk02 2397 7 of of IN cord-014516-r59usk02 2397 8 haematological haematological NNP cord-014516-r59usk02 2397 9 data datum NNS cord-014516-r59usk02 2397 10 revealed reveal VBD cord-014516-r59usk02 2397 11 37 37 CD cord-014516-r59usk02 2397 12 pure pure JJ cord-014516-r59usk02 2397 13 breeds breed NNS cord-014516-r59usk02 2397 14 with with IN cord-014516-r59usk02 2397 15 distinctive distinctive JJ cord-014516-r59usk02 2397 16 phenotypes phenotype NNS cord-014516-r59usk02 2397 17 , , , cord-014516-r59usk02 2397 18 while while IN cord-014516-r59usk02 2397 19 PCA PCA NNP cord-014516-r59usk02 2397 20 of of IN cord-014516-r59usk02 2397 21 serum serum NN cord-014516-r59usk02 2397 22 biochemical biochemical JJ cord-014516-r59usk02 2397 23 data datum NNS cord-014516-r59usk02 2397 24 revealed reveal VBD cord-014516-r59usk02 2397 25 over over IN cord-014516-r59usk02 2397 26 50 50 CD cord-014516-r59usk02 2397 27 pure pure JJ cord-014516-r59usk02 2397 28 breeds breed NNS cord-014516-r59usk02 2397 29 with with IN cord-014516-r59usk02 2397 30 distinctive distinctive JJ cord-014516-r59usk02 2397 31 phenotypes phenotype NNS cord-014516-r59usk02 2397 32 . . . cord-014516-r59usk02 2398 1 Furthermore furthermore RB cord-014516-r59usk02 2398 2 , , , cord-014516-r59usk02 2398 3 all all DT cord-014516-r59usk02 2398 4 haematological haematological JJ cord-014516-r59usk02 2398 5 parameters parameter NNS cord-014516-r59usk02 2398 6 except except IN cord-014516-r59usk02 2398 7 MCHC MCHC NNP cord-014516-r59usk02 2398 8 and and CC cord-014516-r59usk02 2398 9 all all DT cord-014516-r59usk02 2398 10 serum serum NN cord-014516-r59usk02 2398 11 biochemical biochemical JJ cord-014516-r59usk02 2398 12 analytes analyte NNS cord-014516-r59usk02 2398 13 except except IN cord-014516-r59usk02 2398 14 urea urea NN cord-014516-r59usk02 2398 15 and and CC cord-014516-r59usk02 2398 16 glucose glucose NN cord-014516-r59usk02 2398 17 showed show VBD cord-014516-r59usk02 2398 18 significant significant JJ cord-014516-r59usk02 2398 19 differences difference NNS cord-014516-r59usk02 2398 20 between between IN cord-014516-r59usk02 2398 21 specific specific JJ cord-014516-r59usk02 2398 22 individual individual JJ cord-014516-r59usk02 2398 23 breeds breed NNS cord-014516-r59usk02 2398 24 and and CC cord-014516-r59usk02 2398 25 the the DT cord-014516-r59usk02 2398 26 mixed mixed JJ cord-014516-r59usk02 2398 27 breed breed NN cord-014516-r59usk02 2398 28 group group NN cord-014516-r59usk02 2398 29 . . . cord-014516-r59usk02 2399 1 Twenty twenty CD cord-014516-r59usk02 2399 2 - - HYPH cord-014516-r59usk02 2399 3 nine nine CD cord-014516-r59usk02 2399 4 breeds breed NNS cord-014516-r59usk02 2399 5 had have VBD cord-014516-r59usk02 2399 6 distinctive distinctive JJ cord-014516-r59usk02 2399 7 haematological haematological JJ cord-014516-r59usk02 2399 8 phenotypes phenotype NNS cord-014516-r59usk02 2399 9 and and CC cord-014516-r59usk02 2399 10 21 21 CD cord-014516-r59usk02 2399 11 breeds breed NNS cord-014516-r59usk02 2399 12 had have VBD cord-014516-r59usk02 2399 13 distinctive distinctive JJ cord-014516-r59usk02 2399 14 serum serum JJ cord-014516-r59usk02 2399 15 biochemical biochemical JJ cord-014516-r59usk02 2399 16 phenotypes phenotype NNS cord-014516-r59usk02 2399 17 when when WRB cord-014516-r59usk02 2399 18 assessed assess VBN cord-014516-r59usk02 2399 19 in in IN cord-014516-r59usk02 2399 20 this this DT cord-014516-r59usk02 2399 21 way way NN cord-014516-r59usk02 2399 22 . . . cord-014516-r59usk02 2400 1 Tentative tentative JJ cord-014516-r59usk02 2400 2 breed breed NN cord-014516-r59usk02 2400 3 - - HYPH cord-014516-r59usk02 2400 4 specific specific JJ cord-014516-r59usk02 2400 5 reference reference NN cord-014516-r59usk02 2400 6 intervals interval NNS cord-014516-r59usk02 2400 7 were be VBD cord-014516-r59usk02 2400 8 generated generate VBN cord-014516-r59usk02 2400 9 for for IN cord-014516-r59usk02 2400 10 breeds breed NNS cord-014516-r59usk02 2400 11 with with IN cord-014516-r59usk02 2400 12 a a DT cord-014516-r59usk02 2400 13 distinctive distinctive JJ cord-014516-r59usk02 2400 14 phenotype phenotype NN cord-014516-r59usk02 2400 15 identified identify VBN cord-014516-r59usk02 2400 16 by by IN cord-014516-r59usk02 2400 17 comparative comparative JJ cord-014516-r59usk02 2400 18 analysis analysis NN cord-014516-r59usk02 2400 19 . . . cord-014516-r59usk02 2401 1 This this DT cord-014516-r59usk02 2401 2 study study NN cord-014516-r59usk02 2401 3 represents represent VBZ cord-014516-r59usk02 2401 4 the the DT cord-014516-r59usk02 2401 5 first first JJ cord-014516-r59usk02 2401 6 large large JJ cord-014516-r59usk02 2401 7 - - HYPH cord-014516-r59usk02 2401 8 scale scale NN cord-014516-r59usk02 2401 9 analysis analysis NN cord-014516-r59usk02 2401 10 of of IN cord-014516-r59usk02 2401 11 haematological haematological NN cord-014516-r59usk02 2401 12 and and CC cord-014516-r59usk02 2401 13 serum serum JJ cord-014516-r59usk02 2401 14 biochemical biochemical JJ cord-014516-r59usk02 2401 15 phenotypes phenotype NNS cord-014516-r59usk02 2401 16 in in IN cord-014516-r59usk02 2401 17 the the DT cord-014516-r59usk02 2401 18 dog dog NN cord-014516-r59usk02 2401 19 and and CC cord-014516-r59usk02 2401 20 underlines underline VBZ cord-014516-r59usk02 2401 21 the the DT cord-014516-r59usk02 2401 22 important important JJ cord-014516-r59usk02 2401 23 potential potential NN cord-014516-r59usk02 2401 24 of of IN cord-014516-r59usk02 2401 25 this this DT cord-014516-r59usk02 2401 26 species specie NNS cord-014516-r59usk02 2401 27 in in IN cord-014516-r59usk02 2401 28 the the DT cord-014516-r59usk02 2401 29 elucidation elucidation NN cord-014516-r59usk02 2401 30 of of IN cord-014516-r59usk02 2401 31 genetic genetic JJ cord-014516-r59usk02 2401 32 determinants determinant NNS cord-014516-r59usk02 2401 33 of of IN cord-014516-r59usk02 2401 34 haematological haematological JJ cord-014516-r59usk02 2401 35 and and CC cord-014516-r59usk02 2401 36 biochemical biochemical JJ cord-014516-r59usk02 2401 37 traits trait NNS cord-014516-r59usk02 2401 38 , , , cord-014516-r59usk02 2401 39 triangulating triangulate VBG cord-014516-r59usk02 2401 40 phenotype phenotype NN cord-014516-r59usk02 2401 41 , , , cord-014516-r59usk02 2401 42 breed breed NN cord-014516-r59usk02 2401 43 and and CC cord-014516-r59usk02 2401 44 genetic genetic JJ cord-014516-r59usk02 2401 45 predisposition predisposition NN cord-014516-r59usk02 2401 46 , , , cord-014516-r59usk02 2401 47 as as RB cord-014516-r59usk02 2401 48 well well RB cord-014516-r59usk02 2401 49 as as IN cord-014516-r59usk02 2401 50 the the DT cord-014516-r59usk02 2401 51 urgent urgent JJ cord-014516-r59usk02 2401 52 need need NN cord-014516-r59usk02 2401 53 for for IN cord-014516-r59usk02 2401 54 breed breed NN cord-014516-r59usk02 2401 55 - - HYPH cord-014516-r59usk02 2401 56 specific specific JJ cord-014516-r59usk02 2401 57 reference reference NN cord-014516-r59usk02 2401 58 intervals interval NNS cord-014516-r59usk02 2401 59 in in IN cord-014516-r59usk02 2401 60 clinical clinical JJ cord-014516-r59usk02 2401 61 practice practice NN cord-014516-r59usk02 2401 62 . . . cord-014516-r59usk02 2402 1 The the DT cord-014516-r59usk02 2402 2 author author NN cord-014516-r59usk02 2402 3 has have VBZ cord-014516-r59usk02 2402 4 received receive VBN cord-014516-r59usk02 2402 5 funding funding NN cord-014516-r59usk02 2402 6 from from IN cord-014516-r59usk02 2402 7 BBSRC BBSRC NNP cord-014516-r59usk02 2402 8 , , , cord-014516-r59usk02 2402 9 Petplan Petplan NNP cord-014516-r59usk02 2402 10 Charitable Charitable NNP cord-014516-r59usk02 2402 11 Trust Trust NNP cord-014516-r59usk02 2402 12 , , , cord-014516-r59usk02 2402 13 and and CC cord-014516-r59usk02 2402 14 CRUK CRUK NNP cord-014516-r59usk02 2402 15 ) ) -RRB- cord-014516-r59usk02 2402 16 , , , cord-014516-r59usk02 2402 17 but but CC cord-014516-r59usk02 2402 18 none none NN cord-014516-r59usk02 2402 19 of of IN cord-014516-r59usk02 2402 20 thesegrants thesegrant NNS cord-014516-r59usk02 2402 21 were be VBD cord-014516-r59usk02 2402 22 for for IN cord-014516-r59usk02 2402 23 this this DT cord-014516-r59usk02 2402 24 study study NN cord-014516-r59usk02 2402 25 . . . cord-014516-r59usk02 2403 1 For for IN cord-014516-r59usk02 2403 2 each each DT cord-014516-r59usk02 2403 3 cat cat NN cord-014516-r59usk02 2403 4 aged age VBN cord-014516-r59usk02 2403 5 10 10 CD cord-014516-r59usk02 2403 6 years year NNS cord-014516-r59usk02 2403 7 or or CC cord-014516-r59usk02 2403 8 older old JJR cord-014516-r59usk02 2403 9 , , , cord-014516-r59usk02 2403 10 irrespective irrespective RB cord-014516-r59usk02 2403 11 of of IN cord-014516-r59usk02 2403 12 their -PRON- PRP$ cord-014516-r59usk02 2403 13 suspected suspect VBN cord-014516-r59usk02 2403 14 thyroid thyroid NN cord-014516-r59usk02 2403 15 status status NN cord-014516-r59usk02 2403 16 , , , cord-014516-r59usk02 2403 17 presented present VBN cord-014516-r59usk02 2403 18 to to IN cord-014516-r59usk02 2403 19 eight eight CD cord-014516-r59usk02 2403 20 veterinary veterinary JJ cord-014516-r59usk02 2403 21 practices practice NNS cord-014516-r59usk02 2403 22 in in IN cord-014516-r59usk02 2403 23 Portugal Portugal NNP cord-014516-r59usk02 2403 24 , , , cord-014516-r59usk02 2403 25 the the DT cord-014516-r59usk02 2403 26 veterinarian veterinarian NN cord-014516-r59usk02 2403 27 and and CC cord-014516-r59usk02 2403 28 the the DT cord-014516-r59usk02 2403 29 pet pet NN cord-014516-r59usk02 2403 30 owner owner NN cord-014516-r59usk02 2403 31 had have VBD cord-014516-r59usk02 2403 32 to to TO cord-014516-r59usk02 2403 33 complete complete VB cord-014516-r59usk02 2403 34 a a DT cord-014516-r59usk02 2403 35 questionnaire questionnaire NN cord-014516-r59usk02 2403 36 and and CC cord-014516-r59usk02 2403 37 the the DT cord-014516-r59usk02 2403 38 veterinarian veterinarian NN cord-014516-r59usk02 2403 39 had have VBD cord-014516-r59usk02 2403 40 to to TO cord-014516-r59usk02 2403 41 take take VB cord-014516-r59usk02 2403 42 a a DT cord-014516-r59usk02 2403 43 venous venous JJ cord-014516-r59usk02 2403 44 blood blood NN cord-014516-r59usk02 2403 45 sample sample NN cord-014516-r59usk02 2403 46 ( ( -LRB- cord-014516-r59usk02 2403 47 into into IN cord-014516-r59usk02 2403 48 a a DT cord-014516-r59usk02 2403 49 plain plain JJ cord-014516-r59usk02 2403 50 tube tube NN cord-014516-r59usk02 2403 51 ) ) -RRB- cord-014516-r59usk02 2403 52 from from IN cord-014516-r59usk02 2403 53 the the DT cord-014516-r59usk02 2403 54 cat cat NN cord-014516-r59usk02 2403 55 , , , cord-014516-r59usk02 2403 56 after after IN cord-014516-r59usk02 2403 57 obtaining obtain VBG cord-014516-r59usk02 2403 58 signed sign VBN cord-014516-r59usk02 2403 59 owner owner NN cord-014516-r59usk02 2403 60 consent consent NN cord-014516-r59usk02 2403 61 . . . cord-014516-r59usk02 2404 1 The the DT cord-014516-r59usk02 2404 2 veterinary veterinary JJ cord-014516-r59usk02 2404 3 questionnaire questionnaire NN cord-014516-r59usk02 2404 4 included include VBD cord-014516-r59usk02 2404 5 history history NN cord-014516-r59usk02 2404 6 , , , cord-014516-r59usk02 2404 7 attitude attitude NN cord-014516-r59usk02 2404 8 , , , cord-014516-r59usk02 2404 9 activity activity NN cord-014516-r59usk02 2404 10 , , , cord-014516-r59usk02 2404 11 heart heart NN cord-014516-r59usk02 2404 12 rate rate NN cord-014516-r59usk02 2404 13 and and CC cord-014516-r59usk02 2404 14 thyroid thyroid NN cord-014516-r59usk02 2404 15 palpation palpation NN cord-014516-r59usk02 2404 16 . . . cord-014516-r59usk02 2405 1 Cats cat NNS cord-014516-r59usk02 2405 2 aged age VBN cord-014516-r59usk02 2405 3 < < XX cord-014516-r59usk02 2405 4 10 10 CD cord-014516-r59usk02 2405 5 years year NNS cord-014516-r59usk02 2405 6 and and CC cord-014516-r59usk02 2405 7 those those DT cord-014516-r59usk02 2405 8 diagnosed diagnose VBN cord-014516-r59usk02 2405 9 previously previously RB cord-014516-r59usk02 2405 10 with with IN cord-014516-r59usk02 2405 11 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2405 12 were be VBD cord-014516-r59usk02 2405 13 excluded exclude VBN cord-014516-r59usk02 2405 14 . . . cord-014516-r59usk02 2406 1 Blood blood NN cord-014516-r59usk02 2406 2 samples sample NNS cord-014516-r59usk02 2406 3 were be VBD cord-014516-r59usk02 2406 4 centrifuged centrifuge VBN cord-014516-r59usk02 2406 5 and and CC cord-014516-r59usk02 2406 6 the the DT cord-014516-r59usk02 2406 7 serum serum NN cord-014516-r59usk02 2406 8 harvested harvest VBN cord-014516-r59usk02 2406 9 and and CC cord-014516-r59usk02 2406 10 stored store VBN cord-014516-r59usk02 2406 11 frozen frozen JJ cord-014516-r59usk02 2406 12 until until IN cord-014516-r59usk02 2406 13 collection collection NN cord-014516-r59usk02 2406 14 by by IN cord-014516-r59usk02 2406 15 the the DT cord-014516-r59usk02 2406 16 laboratory laboratory NN cord-014516-r59usk02 2406 17 within within IN cord-014516-r59usk02 2406 18 2 2 CD cord-014516-r59usk02 2406 19 days day NNS cord-014516-r59usk02 2406 20 of of IN cord-014516-r59usk02 2406 21 sampling sampling NN cord-014516-r59usk02 2406 22 . . . cord-014516-r59usk02 2407 1 Total total JJ cord-014516-r59usk02 2407 2 T4 T4 NNP cord-014516-r59usk02 2407 3 was be VBD cord-014516-r59usk02 2407 4 measured measure VBN cord-014516-r59usk02 2407 5 using use VBG cord-014516-r59usk02 2407 6 a a DT cord-014516-r59usk02 2407 7 chemiluminescent chemiluminescent NN cord-014516-r59usk02 2407 8 method method NN cord-014516-r59usk02 2407 9 ( ( -LRB- cord-014516-r59usk02 2407 10 Immulite Immulite NNP cord-014516-r59usk02 2407 11 1000 1000 CD cord-014516-r59usk02 2407 12 , , , cord-014516-r59usk02 2407 13 Siemens Siemens NNP cord-014516-r59usk02 2407 14 ) ) -RRB- cord-014516-r59usk02 2407 15 . . . cord-014516-r59usk02 2408 1 Cats cat NNS cord-014516-r59usk02 2408 2 were be VBD cord-014516-r59usk02 2408 3 classified classify VBN cord-014516-r59usk02 2408 4 as as IN cord-014516-r59usk02 2408 5 hyperthyroid hyperthyroid JJ cord-014516-r59usk02 2408 6 , , , cord-014516-r59usk02 2408 7 equivocal equivocal JJ cord-014516-r59usk02 2408 8 or or CC cord-014516-r59usk02 2408 9 euthyroid euthyroid JJ cord-014516-r59usk02 2408 10 based base VBN cord-014516-r59usk02 2408 11 on on IN cord-014516-r59usk02 2408 12 a a DT cord-014516-r59usk02 2408 13 total total JJ cord-014516-r59usk02 2408 14 T4 T4 NNP cord-014516-r59usk02 2408 15 concentration concentration NN cord-014516-r59usk02 2408 16 of of IN cord-014516-r59usk02 2408 17 > > $ cord-014516-r59usk02 2408 18 51 51 CD cord-014516-r59usk02 2408 19 nmol nmol NN cord-014516-r59usk02 2408 20 / / SYM cord-014516-r59usk02 2408 21 L l NN cord-014516-r59usk02 2408 22 , , , cord-014516-r59usk02 2408 23 30 30 CD cord-014516-r59usk02 2408 24 - - SYM cord-014516-r59usk02 2408 25 51 51 CD cord-014516-r59usk02 2408 26 nmol nmol JJ cord-014516-r59usk02 2408 27 / / SYM cord-014516-r59usk02 2408 28 L l NN cord-014516-r59usk02 2408 29 or or CC cord-014516-r59usk02 2408 30 < < NNP cord-014516-r59usk02 2408 31 30 30 CD cord-014516-r59usk02 2408 32 nmol nmol NNP cord-014516-r59usk02 2408 33 / / SYM cord-014516-r59usk02 2408 34 L L NNP cord-014516-r59usk02 2408 35 , , , cord-014516-r59usk02 2408 36 respectively respectively RB cord-014516-r59usk02 2408 37 . . . cord-014516-r59usk02 2409 1 Repeat repeat VB cord-014516-r59usk02 2409 2 measurement measurement NN cord-014516-r59usk02 2409 3 of of IN cord-014516-r59usk02 2409 4 total total JJ cord-014516-r59usk02 2409 5 T4 T4 NNP cord-014516-r59usk02 2409 6 after after IN cord-014516-r59usk02 2409 7 4 4 CD cord-014516-r59usk02 2409 8 - - SYM cord-014516-r59usk02 2409 9 6 6 CD cord-014516-r59usk02 2409 10 weeks week NNS cord-014516-r59usk02 2409 11 was be VBD cord-014516-r59usk02 2409 12 recommended recommend VBN cord-014516-r59usk02 2409 13 for for IN cord-014516-r59usk02 2409 14 all all DT cord-014516-r59usk02 2409 15 equivocal equivocal JJ cord-014516-r59usk02 2409 16 cases case NNS cord-014516-r59usk02 2409 17 . . . cord-014516-r59usk02 2410 1 The the DT cord-014516-r59usk02 2410 2 individual individual JJ cord-014516-r59usk02 2410 3 cat cat NN cord-014516-r59usk02 2410 4 was be VBD cord-014516-r59usk02 2410 5 the the DT cord-014516-r59usk02 2410 6 statistical statistical JJ cord-014516-r59usk02 2410 7 unit unit NN cord-014516-r59usk02 2410 8 . . . cord-014516-r59usk02 2411 1 Descriptive descriptive JJ cord-014516-r59usk02 2411 2 statistics statistic NNS cord-014516-r59usk02 2411 3 was be VBD cord-014516-r59usk02 2411 4 used use VBN cord-014516-r59usk02 2411 5 to to TO cord-014516-r59usk02 2411 6 summarise summarise VB cord-014516-r59usk02 2411 7 the the DT cord-014516-r59usk02 2411 8 data datum NNS cord-014516-r59usk02 2411 9 and and CC cord-014516-r59usk02 2411 10 associations association NNS cord-014516-r59usk02 2411 11 between between IN cord-014516-r59usk02 2411 12 different different JJ cord-014516-r59usk02 2411 13 clinical clinical JJ cord-014516-r59usk02 2411 14 signs sign NNS cord-014516-r59usk02 2411 15 analysed analyse VBD cord-014516-r59usk02 2411 16 using use VBG cord-014516-r59usk02 2411 17 Chi Chi NNP cord-014516-r59usk02 2411 18 - - HYPH cord-014516-r59usk02 2411 19 square square NNP cord-014516-r59usk02 2411 20 , , , cord-014516-r59usk02 2411 21 Fisher Fisher NNP cord-014516-r59usk02 2411 22 's 's POS cord-014516-r59usk02 2411 23 exact exact JJ cord-014516-r59usk02 2411 24 test test NN cord-014516-r59usk02 2411 25 or or CC cord-014516-r59usk02 2411 26 the the DT cord-014516-r59usk02 2411 27 Mann Mann NNP cord-014516-r59usk02 2411 28 - - HYPH cord-014516-r59usk02 2411 29 Whitney Whitney NNP cord-014516-r59usk02 2411 30 U U NNP cord-014516-r59usk02 2411 31 test test NN cord-014516-r59usk02 2411 32 . . . cord-014516-r59usk02 2412 1 The the DT cord-014516-r59usk02 2412 2 level level NN cord-014516-r59usk02 2412 3 of of IN cord-014516-r59usk02 2412 4 significance significance NN cord-014516-r59usk02 2412 5 was be VBD cord-014516-r59usk02 2412 6 set set VBN cord-014516-r59usk02 2412 7 at at IN cord-014516-r59usk02 2412 8 0.05 0.05 CD cord-014516-r59usk02 2412 9 . . . cord-014516-r59usk02 2413 1 Thirty thirty CD cord-014516-r59usk02 2413 2 cats cat NNS cord-014516-r59usk02 2413 3 were be VBD cord-014516-r59usk02 2413 4 excluded exclude VBN cord-014516-r59usk02 2413 5 from from IN cord-014516-r59usk02 2413 6 the the DT cord-014516-r59usk02 2413 7 prevalence prevalence NN cord-014516-r59usk02 2413 8 analysis analysis NN cord-014516-r59usk02 2413 9 because because IN cord-014516-r59usk02 2413 10 they -PRON- PRP cord-014516-r59usk02 2413 11 were be VBD cord-014516-r59usk02 2413 12 aged age VBN cord-014516-r59usk02 2413 13 < < XX cord-014516-r59usk02 2413 14 10 10 CD cord-014516-r59usk02 2413 15 years year NNS cord-014516-r59usk02 2413 16 ( ( -LRB- cord-014516-r59usk02 2413 17 between between IN cord-014516-r59usk02 2413 18 4 4 CD cord-014516-r59usk02 2413 19 and and CC cord-014516-r59usk02 2413 20 9 9 CD cord-014516-r59usk02 2413 21 years year NNS cord-014516-r59usk02 2413 22 , , , cord-014516-r59usk02 2413 23 n n NN cord-014516-r59usk02 2413 24 = = SYM cord-014516-r59usk02 2413 25 11 11 CD cord-014516-r59usk02 2413 26 ) ) -RRB- cord-014516-r59usk02 2413 27 or or CC cord-014516-r59usk02 2413 28 their -PRON- PRP$ cord-014516-r59usk02 2413 29 age age NN cord-014516-r59usk02 2413 30 was be VBD cord-014516-r59usk02 2413 31 not not RB cord-014516-r59usk02 2413 32 stated state VBN cord-014516-r59usk02 2413 33 ( ( -LRB- cord-014516-r59usk02 2413 34 n n NN cord-014516-r59usk02 2413 35 = = SYM cord-014516-r59usk02 2413 36 19 19 CD cord-014516-r59usk02 2413 37 , , , cord-014516-r59usk02 2413 38 four four CD cord-014516-r59usk02 2413 39 of of IN cord-014516-r59usk02 2413 40 these these DT cord-014516-r59usk02 2413 41 cats cat NNS cord-014516-r59usk02 2413 42 were be VBD cord-014516-r59usk02 2413 43 hyperthyroid hyperthyroid JJ cord-014516-r59usk02 2413 44 ) ) -RRB- cord-014516-r59usk02 2413 45 . . . cord-014516-r59usk02 2414 1 By by IN cord-014516-r59usk02 2414 2 the the DT cord-014516-r59usk02 2414 3 end end NN cord-014516-r59usk02 2414 4 of of IN cord-014516-r59usk02 2414 5 February February NNP cord-014516-r59usk02 2414 6 2014 2014 CD cord-014516-r59usk02 2414 7 , , , cord-014516-r59usk02 2414 8 samples sample NNS cord-014516-r59usk02 2414 9 had have VBD cord-014516-r59usk02 2414 10 been be VBN cord-014516-r59usk02 2414 11 submitted submit VBN cord-014516-r59usk02 2414 12 from from IN cord-014516-r59usk02 2414 13 197 197 CD cord-014516-r59usk02 2414 14 cats cat NNS cord-014516-r59usk02 2414 15 that that WDT cord-014516-r59usk02 2414 16 met meet VBD cord-014516-r59usk02 2414 17 the the DT cord-014516-r59usk02 2414 18 inclusion inclusion NN cord-014516-r59usk02 2414 19 criteria criterion NNS cord-014516-r59usk02 2414 20 . . . cord-014516-r59usk02 2415 1 Based base VBN cord-014516-r59usk02 2415 2 on on IN cord-014516-r59usk02 2415 3 the the DT cord-014516-r59usk02 2415 4 thyroid thyroid JJ cord-014516-r59usk02 2415 5 hormone hormone NN cord-014516-r59usk02 2415 6 analysis analysis NN cord-014516-r59usk02 2415 7 , , , cord-014516-r59usk02 2415 8 there there EX cord-014516-r59usk02 2415 9 were be VBD cord-014516-r59usk02 2415 10 14/197 14/197 CD cord-014516-r59usk02 2415 11 ( ( -LRB- cord-014516-r59usk02 2415 12 9 9 CD cord-014516-r59usk02 2415 13 % % NN cord-014516-r59usk02 2415 14 ) ) -RRB- cord-014516-r59usk02 2415 15 hyperthyroid hyperthyroid JJ cord-014516-r59usk02 2415 16 , , , cord-014516-r59usk02 2415 17 28 28 CD cord-014516-r59usk02 2415 18 ( ( -LRB- cord-014516-r59usk02 2415 19 14 14 CD cord-014516-r59usk02 2415 20 % % NN cord-014516-r59usk02 2415 21 ) ) -RRB- cord-014516-r59usk02 2415 22 equivocal equivocal JJ cord-014516-r59usk02 2415 23 and and CC cord-014516-r59usk02 2415 24 152 152 CD cord-014516-r59usk02 2415 25 ( ( -LRB- cord-014516-r59usk02 2415 26 77 77 CD cord-014516-r59usk02 2415 27 % % NN cord-014516-r59usk02 2415 28 ) ) -RRB- cord-014516-r59usk02 2416 1 euthyroid euthyroid NNP cord-014516-r59usk02 2416 2 cats cat NNS cord-014516-r59usk02 2416 3 . . . cord-014516-r59usk02 2417 1 Very very RB cord-014516-r59usk02 2417 2 few few JJ cord-014516-r59usk02 2417 3 follow follow NN cord-014516-r59usk02 2417 4 - - HYPH cord-014516-r59usk02 2417 5 up up RP cord-014516-r59usk02 2417 6 blood blood NN cord-014516-r59usk02 2417 7 samples sample NNS cord-014516-r59usk02 2417 8 were be VBD cord-014516-r59usk02 2417 9 taken take VBN cord-014516-r59usk02 2417 10 . . . cord-014516-r59usk02 2418 1 Hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2418 2 appears appear VBZ cord-014516-r59usk02 2418 3 to to TO cord-014516-r59usk02 2418 4 be be VB cord-014516-r59usk02 2418 5 not not RB cord-014516-r59usk02 2418 6 uncommon uncommon JJ cord-014516-r59usk02 2418 7 in in IN cord-014516-r59usk02 2418 8 Portuguese portuguese JJ cord-014516-r59usk02 2418 9 cats cat NNS cord-014516-r59usk02 2418 10 . . . cord-014516-r59usk02 2419 1 Getting get VBG cord-014516-r59usk02 2419 2 owners owner NNS cord-014516-r59usk02 2419 3 to to TO cord-014516-r59usk02 2419 4 return return VB cord-014516-r59usk02 2419 5 for for IN cord-014516-r59usk02 2419 6 follow follow NN cord-014516-r59usk02 2419 7 - - HYPH cord-014516-r59usk02 2419 8 up up RP cord-014516-r59usk02 2419 9 blood blood NN cord-014516-r59usk02 2419 10 sampling sampling NN cord-014516-r59usk02 2419 11 appears appear VBZ cord-014516-r59usk02 2419 12 to to TO cord-014516-r59usk02 2419 13 be be VB cord-014516-r59usk02 2419 14 problematic problematic JJ cord-014516-r59usk02 2419 15 . . . cord-014516-r59usk02 2420 1 Under under IN cord-014516-r59usk02 2420 2 - - HYPH cord-014516-r59usk02 2420 3 reporting reporting NN cord-014516-r59usk02 2420 4 of of IN cord-014516-r59usk02 2420 5 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2420 6 appears appear VBZ cord-014516-r59usk02 2420 7 to to TO cord-014516-r59usk02 2420 8 be be VB cord-014516-r59usk02 2420 9 a a DT cord-014516-r59usk02 2420 10 significant significant JJ cord-014516-r59usk02 2420 11 problem problem NN cord-014516-r59usk02 2420 12 in in IN cord-014516-r59usk02 2420 13 Portugal Portugal NNP cord-014516-r59usk02 2420 14 , , , cord-014516-r59usk02 2420 15 as as IN cord-014516-r59usk02 2420 16 has have VBZ cord-014516-r59usk02 2420 17 been be VBN cord-014516-r59usk02 2420 18 reported report VBN cord-014516-r59usk02 2420 19 for for IN cord-014516-r59usk02 2420 20 some some DT cord-014516-r59usk02 2420 21 other other JJ cord-014516-r59usk02 2420 22 countries country NNS cord-014516-r59usk02 2420 23 . . . cord-014516-r59usk02 2421 1 Thyroid thyroid JJ cord-014516-r59usk02 2421 2 palpation palpation NN cord-014516-r59usk02 2421 3 should should MD cord-014516-r59usk02 2421 4 form form VB cord-014516-r59usk02 2421 5 part part NN cord-014516-r59usk02 2421 6 of of IN cord-014516-r59usk02 2421 7 routine routine JJ cord-014516-r59usk02 2421 8 physical physical JJ cord-014516-r59usk02 2421 9 examinations examination NNS cord-014516-r59usk02 2421 10 , , , cord-014516-r59usk02 2421 11 especially especially RB cord-014516-r59usk02 2421 12 of of IN cord-014516-r59usk02 2421 13 middle middle JJ cord-014516-r59usk02 2421 14 aged aged JJ cord-014516-r59usk02 2421 15 and and CC cord-014516-r59usk02 2421 16 older old JJR cord-014516-r59usk02 2421 17 cats cat NNS cord-014516-r59usk02 2421 18 . . . cord-014516-r59usk02 2422 1 Older old JJR cord-014516-r59usk02 2422 2 cats cat NNS cord-014516-r59usk02 2422 3 in in IN cord-014516-r59usk02 2422 4 Portugal Portugal NNP cord-014516-r59usk02 2422 5 should should MD cord-014516-r59usk02 2422 6 be be VB cord-014516-r59usk02 2422 7 screened screen VBN cord-014516-r59usk02 2422 8 for for IN cord-014516-r59usk02 2422 9 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2422 10 even even RB cord-014516-r59usk02 2422 11 in in IN cord-014516-r59usk02 2422 12 the the DT cord-014516-r59usk02 2422 13 absence absence NN cord-014516-r59usk02 2422 14 of of IN cord-014516-r59usk02 2422 15 a a DT cord-014516-r59usk02 2422 16 detectable detectable JJ cord-014516-r59usk02 2422 17 thyroid thyroid NN cord-014516-r59usk02 2422 18 nodule nodule NN cord-014516-r59usk02 2422 19 . . . cord-014516-r59usk02 2423 1 Both both DT cord-014516-r59usk02 2423 2 authors author NNS cord-014516-r59usk02 2423 3 are be VBP cord-014516-r59usk02 2423 4 employees employee NNS cord-014516-r59usk02 2423 5 of of IN cord-014516-r59usk02 2423 6 MSD MSD NNP cord-014516-r59usk02 2423 7 Animal Animal NNP cord-014516-r59usk02 2423 8 Health Health NNP cord-014516-r59usk02 2423 9 . . . cord-014516-r59usk02 2424 1 MSD MSD NNP cord-014516-r59usk02 2424 2 Animal Animal NNP cord-014516-r59usk02 2424 3 Health Health NNP cord-014516-r59usk02 2424 4 funded fund VBD cord-014516-r59usk02 2424 5 the the DT cord-014516-r59usk02 2424 6 study study NN cord-014516-r59usk02 2424 7 . . . cord-014516-r59usk02 2425 1 MSD MSD NNP cord-014516-r59usk02 2425 2 Animal Animal NNP cord-014516-r59usk02 2425 3 Health Health NNP cord-014516-r59usk02 2425 4 has have VBZ cord-014516-r59usk02 2425 5 an an DT cord-014516-r59usk02 2425 6 approved approve VBN cord-014516-r59usk02 2425 7 veterinary veterinary JJ cord-014516-r59usk02 2425 8 medicinal medicinal JJ cord-014516-r59usk02 2425 9 product product NN cord-014516-r59usk02 2425 10 for for IN cord-014516-r59usk02 2425 11 the the DT cord-014516-r59usk02 2425 12 treatment treatment NN cord-014516-r59usk02 2425 13 of of IN cord-014516-r59usk02 2425 14 feline feline JJ cord-014516-r59usk02 2425 15 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2425 16 . . . cord-014516-r59usk02 2426 1 This this DT cord-014516-r59usk02 2426 2 product product NN cord-014516-r59usk02 2426 3 is be VBZ cord-014516-r59usk02 2426 4 available available JJ cord-014516-r59usk02 2426 5 commercially commercially RB cord-014516-r59usk02 2426 6 in in IN cord-014516-r59usk02 2426 7 some some DT cord-014516-r59usk02 2426 8 EU EU NNP cord-014516-r59usk02 2426 9 markets market NNS cord-014516-r59usk02 2426 10 but but CC cord-014516-r59usk02 2426 11 not not RB cord-014516-r59usk02 2426 12 in in IN cord-014516-r59usk02 2426 13 Portugal Portugal NNP cord-014516-r59usk02 2426 14 . . . cord-014516-r59usk02 2427 1 Diabetes diabetes NN cord-014516-r59usk02 2427 2 mellitus mellitus NN cord-014516-r59usk02 2427 3 is be VBZ cord-014516-r59usk02 2427 4 one one CD cord-014516-r59usk02 2427 5 of of IN cord-014516-r59usk02 2427 6 the the DT cord-014516-r59usk02 2427 7 most most RBS cord-014516-r59usk02 2427 8 commonly commonly RB cord-014516-r59usk02 2427 9 encountered encounter VBN cord-014516-r59usk02 2427 10 endocrinopathies endocrinopathie NNS cord-014516-r59usk02 2427 11 in in IN cord-014516-r59usk02 2427 12 cats cat NNS cord-014516-r59usk02 2427 13 and and CC cord-014516-r59usk02 2427 14 its -PRON- PRP$ cord-014516-r59usk02 2427 15 prevalence prevalence NN cord-014516-r59usk02 2427 16 has have VBZ cord-014516-r59usk02 2427 17 increased increase VBN cord-014516-r59usk02 2427 18 in in IN cord-014516-r59usk02 2427 19 the the DT cord-014516-r59usk02 2427 20 past past NN cord-014516-r59usk02 2427 21 . . . cord-014516-r59usk02 2428 1 Similar similar JJ cord-014516-r59usk02 2428 2 to to IN cord-014516-r59usk02 2428 3 human human JJ cord-014516-r59usk02 2428 4 Type type NN cord-014516-r59usk02 2428 5 2 2 CD cord-014516-r59usk02 2428 6 Diabetes diabetes NN cord-014516-r59usk02 2428 7 , , , cord-014516-r59usk02 2428 8 feline feline JJ cord-014516-r59usk02 2428 9 Diabetes diabetes NN cord-014516-r59usk02 2428 10 is be VBZ cord-014516-r59usk02 2428 11 associated associate VBN cord-014516-r59usk02 2428 12 with with IN cord-014516-r59usk02 2428 13 comparable comparable JJ cord-014516-r59usk02 2428 14 lesions lesion NNS cord-014516-r59usk02 2428 15 occurring occur VBG cord-014516-r59usk02 2428 16 in in IN cord-014516-r59usk02 2428 17 the the DT cord-014516-r59usk02 2428 18 pancreatic pancreatic JJ cord-014516-r59usk02 2428 19 islets islet NNS cord-014516-r59usk02 2428 20 , , , cord-014516-r59usk02 2428 21 namely namely RB cord-014516-r59usk02 2428 22 islet islet NN cord-014516-r59usk02 2428 23 amyloidosis amyloidosis NN cord-014516-r59usk02 2428 24 and and CC cord-014516-r59usk02 2428 25 beta beta NN cord-014516-r59usk02 2428 26 - - HYPH cord-014516-r59usk02 2428 27 cell cell NN cord-014516-r59usk02 2428 28 loss loss NN cord-014516-r59usk02 2428 29 . . . cord-014516-r59usk02 2429 1 Studying study VBG cord-014516-r59usk02 2429 2 the the DT cord-014516-r59usk02 2429 3 pathophysiology pathophysiology NN cord-014516-r59usk02 2429 4 of of IN cord-014516-r59usk02 2429 5 feline feline JJ cord-014516-r59usk02 2429 6 diabetes diabetes NN cord-014516-r59usk02 2429 7 and and CC cord-014516-r59usk02 2429 8 the the DT cord-014516-r59usk02 2429 9 molecular molecular JJ cord-014516-r59usk02 2429 10 mechanisms mechanism NNS cord-014516-r59usk02 2429 11 through through IN cord-014516-r59usk02 2429 12 which which WDT cord-014516-r59usk02 2429 13 glucose glucose NN cord-014516-r59usk02 2429 14 metabolism metabolism NN cord-014516-r59usk02 2429 15 is be VBZ cord-014516-r59usk02 2429 16 disturbed disturb VBN cord-014516-r59usk02 2429 17 is be VBZ cord-014516-r59usk02 2429 18 largely largely RB cord-014516-r59usk02 2429 19 hampered hamper VBN cord-014516-r59usk02 2429 20 by by IN cord-014516-r59usk02 2429 21 the the DT cord-014516-r59usk02 2429 22 lack lack NN cord-014516-r59usk02 2429 23 of of IN cord-014516-r59usk02 2429 24 a a DT cord-014516-r59usk02 2429 25 method method NN cord-014516-r59usk02 2429 26 for for IN cord-014516-r59usk02 2429 27 the the DT cord-014516-r59usk02 2429 28 isolation isolation NN cord-014516-r59usk02 2429 29 of of IN cord-014516-r59usk02 2429 30 pure pure JJ cord-014516-r59usk02 2429 31 pancreatic pancreatic JJ cord-014516-r59usk02 2429 32 islets islet NNS cord-014516-r59usk02 2429 33 . . . cord-014516-r59usk02 2430 1 The the DT cord-014516-r59usk02 2430 2 aim aim NN cord-014516-r59usk02 2430 3 of of IN cord-014516-r59usk02 2430 4 this this DT cord-014516-r59usk02 2430 5 project project NN cord-014516-r59usk02 2430 6 was be VBD cord-014516-r59usk02 2430 7 to to TO cord-014516-r59usk02 2430 8 improve improve VB cord-014516-r59usk02 2430 9 a a DT cord-014516-r59usk02 2430 10 previously previously RB cord-014516-r59usk02 2430 11 established establish VBN cord-014516-r59usk02 2430 12 method method NN cord-014516-r59usk02 2430 13 for for IN cord-014516-r59usk02 2430 14 the the DT cord-014516-r59usk02 2430 15 isolation isolation NN cord-014516-r59usk02 2430 16 of of IN cord-014516-r59usk02 2430 17 pancreatic pancreatic JJ cord-014516-r59usk02 2430 18 islets islet NNS cord-014516-r59usk02 2430 19 ; ; : cord-014516-r59usk02 2430 20 in in IN cord-014516-r59usk02 2430 21 particular particular JJ cord-014516-r59usk02 2430 22 enhancing enhance VBG cord-014516-r59usk02 2430 23 the the DT cord-014516-r59usk02 2430 24 purity purity NN cord-014516-r59usk02 2430 25 of of IN cord-014516-r59usk02 2430 26 isolated isolate VBN cord-014516-r59usk02 2430 27 islets islet NNS cord-014516-r59usk02 2430 28 in in IN cord-014516-r59usk02 2430 29 this this DT cord-014516-r59usk02 2430 30 species specie NNS cord-014516-r59usk02 2430 31 . . . cord-014516-r59usk02 2431 1 Cats cat NNS cord-014516-r59usk02 2431 2 that that WDT cord-014516-r59usk02 2431 3 died die VBD cord-014516-r59usk02 2431 4 or or CC cord-014516-r59usk02 2431 5 were be VBD cord-014516-r59usk02 2431 6 euthanized euthanize VBN cord-014516-r59usk02 2431 7 due due IN cord-014516-r59usk02 2431 8 to to IN cord-014516-r59usk02 2431 9 severe severe JJ cord-014516-r59usk02 2431 10 illness illness NN cord-014516-r59usk02 2431 11 other other JJ cord-014516-r59usk02 2431 12 than than IN cord-014516-r59usk02 2431 13 pancreatitis pancreatitis NN cord-014516-r59usk02 2431 14 or or CC cord-014516-r59usk02 2431 15 other other JJ cord-014516-r59usk02 2431 16 pancreatic pancreatic NN cord-014516-r59usk02 2431 17 disease disease NN cord-014516-r59usk02 2431 18 were be VBD cord-014516-r59usk02 2431 19 enrolled enrol VBN cord-014516-r59usk02 2431 20 . . . cord-014516-r59usk02 2432 1 Pancreata Pancreata NNP cord-014516-r59usk02 2432 2 were be VBD cord-014516-r59usk02 2432 3 perfused perfuse VBN cord-014516-r59usk02 2432 4 post post NN cord-014516-r59usk02 2432 5 - - JJ cord-014516-r59usk02 2432 6 mortem mortem JJ cord-014516-r59usk02 2432 7 with with IN cord-014516-r59usk02 2432 8 50 50 CD cord-014516-r59usk02 2432 9 ml ml NN cord-014516-r59usk02 2432 10 Collagenase Collagenase NNP cord-014516-r59usk02 2432 11 Type Type NNP cord-014516-r59usk02 2432 12 IV IV NNP cord-014516-r59usk02 2432 13 ( ( -LRB- cord-014516-r59usk02 2432 14 0.5 0.5 CD cord-014516-r59usk02 2432 15 mg mg NNP cord-014516-r59usk02 2432 16 / / SYM cord-014516-r59usk02 2432 17 ml ml NNP cord-014516-r59usk02 2432 18 ) ) -RRB- cord-014516-r59usk02 2432 19 through through IN cord-014516-r59usk02 2432 20 the the DT cord-014516-r59usk02 2432 21 pancreatic pancreatic JJ cord-014516-r59usk02 2432 22 duct duct NN cord-014516-r59usk02 2432 23 . . . cord-014516-r59usk02 2433 1 The the DT cord-014516-r59usk02 2433 2 perfused perfuse VBN cord-014516-r59usk02 2433 3 organ organ NN cord-014516-r59usk02 2433 4 was be VBD cord-014516-r59usk02 2433 5 then then RB cord-014516-r59usk02 2433 6 digested digest VBN cord-014516-r59usk02 2433 7 for for IN cord-014516-r59usk02 2433 8 30 30 CD cord-014516-r59usk02 2433 9 ' ' '' cord-014516-r59usk02 2433 10 , , , cord-014516-r59usk02 2433 11 40 40 CD cord-014516-r59usk02 2433 12 ' ' '' cord-014516-r59usk02 2433 13 and and CC cord-014516-r59usk02 2433 14 60 60 CD cord-014516-r59usk02 2433 15 ' ' '' cord-014516-r59usk02 2433 16 at at IN cord-014516-r59usk02 2433 17 37 37 CD cord-014516-r59usk02 2433 18 ° ° NN cord-014516-r59usk02 2433 19 C c NN cord-014516-r59usk02 2433 20 in in IN cord-014516-r59usk02 2433 21 a a DT cord-014516-r59usk02 2433 22 water water NN cord-014516-r59usk02 2433 23 - - HYPH cord-014516-r59usk02 2433 24 bath bath NN cord-014516-r59usk02 2433 25 and and CC cord-014516-r59usk02 2433 26 purified purify VBN cord-014516-r59usk02 2433 27 using use VBG cord-014516-r59usk02 2433 28 a a DT cord-014516-r59usk02 2433 29 filtration filtration NN cord-014516-r59usk02 2433 30 method method NN cord-014516-r59usk02 2433 31 . . . cord-014516-r59usk02 2434 1 Islet islet NN cord-014516-r59usk02 2434 2 cell cell NN cord-014516-r59usk02 2434 3 viability viability NN cord-014516-r59usk02 2434 4 and and CC cord-014516-r59usk02 2434 5 purity purity NN cord-014516-r59usk02 2434 6 were be VBD cord-014516-r59usk02 2434 7 determined determine VBN cord-014516-r59usk02 2434 8 by by IN cord-014516-r59usk02 2434 9 Thiazolyl Thiazolyl NNP cord-014516-r59usk02 2434 10 Blue Blue NNP cord-014516-r59usk02 2434 11 Tetrazolium Tetrazolium NNP cord-014516-r59usk02 2434 12 Bromide Bromide NNP cord-014516-r59usk02 2434 13 ( ( -LRB- cord-014516-r59usk02 2434 14 MTT MTT NNP cord-014516-r59usk02 2434 15 assay assay NN cord-014516-r59usk02 2434 16 ) ) -RRB- cord-014516-r59usk02 2434 17 and and CC cord-014516-r59usk02 2434 18 dithizone dithizone NN cord-014516-r59usk02 2434 19 staining staining NN cord-014516-r59usk02 2434 20 , , , cord-014516-r59usk02 2434 21 respectively respectively RB cord-014516-r59usk02 2434 22 . . . cord-014516-r59usk02 2435 1 Perfusing perfuse VBG cord-014516-r59usk02 2435 2 the the DT cord-014516-r59usk02 2435 3 pancreas pancrea NNS cord-014516-r59usk02 2435 4 through through IN cord-014516-r59usk02 2435 5 the the DT cord-014516-r59usk02 2435 6 pancreatic pancreatic JJ cord-014516-r59usk02 2435 7 duct duct NN cord-014516-r59usk02 2435 8 allowed allow VBD cord-014516-r59usk02 2435 9 collagenase collagenase NNP cord-014516-r59usk02 2435 10 to to TO cord-014516-r59usk02 2435 11 access access VB cord-014516-r59usk02 2435 12 the the DT cord-014516-r59usk02 2435 13 islets islet NNS cord-014516-r59usk02 2435 14 using use VBG cord-014516-r59usk02 2435 15 anatomical anatomical JJ cord-014516-r59usk02 2435 16 structures structure NNS cord-014516-r59usk02 2435 17 and and CC cord-014516-r59usk02 2435 18 to to TO cord-014516-r59usk02 2435 19 improve improve VB cord-014516-r59usk02 2435 20 islet islet NN cord-014516-r59usk02 2435 21 yield yield NN cord-014516-r59usk02 2435 22 compared compare VBN cord-014516-r59usk02 2435 23 to to IN cord-014516-r59usk02 2435 24 previously previously RB cord-014516-r59usk02 2435 25 established establish VBN cord-014516-r59usk02 2435 26 protocols protocol NNS cord-014516-r59usk02 2435 27 in in IN cord-014516-r59usk02 2435 28 this this DT cord-014516-r59usk02 2435 29 species specie NNS cord-014516-r59usk02 2435 30 . . . cord-014516-r59usk02 2436 1 The the DT cord-014516-r59usk02 2436 2 digestion digestion NN cord-014516-r59usk02 2436 3 time time NN cord-014516-r59usk02 2436 4 of of IN cord-014516-r59usk02 2436 5 60 60 NNP cord-014516-r59usk02 2436 6 ' ' '' cord-014516-r59usk02 2436 7 provided provide VBD cord-014516-r59usk02 2436 8 the the DT cord-014516-r59usk02 2436 9 best good JJS cord-014516-r59usk02 2436 10 islet islet NN cord-014516-r59usk02 2436 11 yield yield NN cord-014516-r59usk02 2436 12 . . . cord-014516-r59usk02 2437 1 After after IN cord-014516-r59usk02 2437 2 digestion digestion NN cord-014516-r59usk02 2437 3 , , , cord-014516-r59usk02 2437 4 feline feline JJ cord-014516-r59usk02 2437 5 pancreatic pancreatic JJ cord-014516-r59usk02 2437 6 islets islet NNS cord-014516-r59usk02 2437 7 remained remain VBD cord-014516-r59usk02 2437 8 satisfactorily satisfactorily RB cord-014516-r59usk02 2437 9 viable viable JJ cord-014516-r59usk02 2437 10 for for IN cord-014516-r59usk02 2437 11 5 5 CD cord-014516-r59usk02 2437 12 days day NNS cord-014516-r59usk02 2437 13 in in IN cord-014516-r59usk02 2437 14 the the DT cord-014516-r59usk02 2437 15 culture culture NN cord-014516-r59usk02 2437 16 system system NN cord-014516-r59usk02 2437 17 following follow VBG cord-014516-r59usk02 2437 18 regular regular JJ cord-014516-r59usk02 2437 19 media medium NNS cord-014516-r59usk02 2437 20 changes change NNS cord-014516-r59usk02 2437 21 . . . cord-014516-r59usk02 2438 1 The the DT cord-014516-r59usk02 2438 2 current current JJ cord-014516-r59usk02 2438 3 study study NN cord-014516-r59usk02 2438 4 has have VBZ cord-014516-r59usk02 2438 5 successfully successfully RB cord-014516-r59usk02 2438 6 optimized optimize VBN cord-014516-r59usk02 2438 7 the the DT cord-014516-r59usk02 2438 8 isolation isolation NN cord-014516-r59usk02 2438 9 , , , cord-014516-r59usk02 2438 10 purification purification NN cord-014516-r59usk02 2438 11 and and CC cord-014516-r59usk02 2438 12 culture culture NN cord-014516-r59usk02 2438 13 maintenance maintenance NN cord-014516-r59usk02 2438 14 of of IN cord-014516-r59usk02 2438 15 feline feline JJ cord-014516-r59usk02 2438 16 islets islet NNS cord-014516-r59usk02 2438 17 . . . cord-014516-r59usk02 2439 1 The the DT cord-014516-r59usk02 2439 2 successful successful JJ cord-014516-r59usk02 2439 3 yield yield NN cord-014516-r59usk02 2439 4 and and CC cord-014516-r59usk02 2439 5 viability viability NN cord-014516-r59usk02 2439 6 of of IN cord-014516-r59usk02 2439 7 islets islet NNS cord-014516-r59usk02 2439 8 isolated isolate VBN cord-014516-r59usk02 2439 9 through through IN cord-014516-r59usk02 2439 10 the the DT cord-014516-r59usk02 2439 11 suggested suggest VBN cord-014516-r59usk02 2439 12 protocol protocol NN cord-014516-r59usk02 2439 13 may may MD cord-014516-r59usk02 2439 14 provide provide VB cord-014516-r59usk02 2439 15 promising promising JJ cord-014516-r59usk02 2439 16 potential potential NN cord-014516-r59usk02 2439 17 as as IN cord-014516-r59usk02 2439 18 a a DT cord-014516-r59usk02 2439 19 source source NN cord-014516-r59usk02 2439 20 of of IN cord-014516-r59usk02 2439 21 islets islet NNS cord-014516-r59usk02 2439 22 for for IN cord-014516-r59usk02 2439 23 diabetes diabetes NN cord-014516-r59usk02 2439 24 research research NN cord-014516-r59usk02 2439 25 in in IN cord-014516-r59usk02 2439 26 cats cat NNS cord-014516-r59usk02 2439 27 . . . cord-014516-r59usk02 2440 1 No no DT cord-014516-r59usk02 2440 2 conflicts conflict NNS cord-014516-r59usk02 2440 3 of of IN cord-014516-r59usk02 2440 4 interest interest NN cord-014516-r59usk02 2440 5 reported report VBN cord-014516-r59usk02 2440 6 . . . cord-014516-r59usk02 2441 1 Nesidioblastosis Nesidioblastosis NNP cord-014516-r59usk02 2441 2 describes describe VBZ cord-014516-r59usk02 2441 3 a a DT cord-014516-r59usk02 2441 4 syndrome syndrome NN cord-014516-r59usk02 2441 5 of of IN cord-014516-r59usk02 2441 6 acquired acquire VBN cord-014516-r59usk02 2441 7 hyperinsulinaemia hyperinsulinaemia NNP cord-014516-r59usk02 2441 8 and and CC cord-014516-r59usk02 2441 9 associated associate VBD cord-014516-r59usk02 2441 10 hypoglycaemia hypoglycaemia NN cord-014516-r59usk02 2441 11 secondary secondary JJ cord-014516-r59usk02 2441 12 to to IN cord-014516-r59usk02 2441 13 focal focal JJ cord-014516-r59usk02 2441 14 or or CC cord-014516-r59usk02 2441 15 diffuse diffuse JJ cord-014516-r59usk02 2441 16 ( ( -LRB- cord-014516-r59usk02 2441 17 non non JJ cord-014516-r59usk02 2441 18 - - JJ cord-014516-r59usk02 2441 19 neoplastic neoplastic JJ cord-014516-r59usk02 2441 20 ) ) -RRB- cord-014516-r59usk02 2441 21 beta beta JJ cord-014516-r59usk02 2441 22 cell cell NN cord-014516-r59usk02 2441 23 hyperplasia hyperplasia NN cord-014516-r59usk02 2441 24 within within IN cord-014516-r59usk02 2441 25 the the DT cord-014516-r59usk02 2441 26 pancreas pancreas NN cord-014516-r59usk02 2441 27 . . . cord-014516-r59usk02 2442 1 Beta beta JJ cord-014516-r59usk02 2442 2 cell cell NN cord-014516-r59usk02 2442 3 dysregulation dysregulation NN cord-014516-r59usk02 2442 4 is be VBZ cord-014516-r59usk02 2442 5 thought think VBN cord-014516-r59usk02 2442 6 to to TO cord-014516-r59usk02 2442 7 occur occur VB cord-014516-r59usk02 2442 8 secondary secondary JJ cord-014516-r59usk02 2442 9 to to IN cord-014516-r59usk02 2442 10 pancreatic pancreatic JJ cord-014516-r59usk02 2442 11 injury injury NN cord-014516-r59usk02 2442 12 . . . cord-014516-r59usk02 2443 1 This this DT cord-014516-r59usk02 2443 2 syndrome syndrome NN cord-014516-r59usk02 2443 3 has have VBZ cord-014516-r59usk02 2443 4 been be VBN cord-014516-r59usk02 2443 5 reported report VBN cord-014516-r59usk02 2443 6 in in IN cord-014516-r59usk02 2443 7 humans human NNS cord-014516-r59usk02 2443 8 with with IN cord-014516-r59usk02 2443 9 increasing increase VBG cord-014516-r59usk02 2443 10 frequency frequency NN cord-014516-r59usk02 2443 11 , , , cord-014516-r59usk02 2443 12 but but CC cord-014516-r59usk02 2443 13 it -PRON- PRP cord-014516-r59usk02 2443 14 has have VBZ cord-014516-r59usk02 2443 15 not not RB cord-014516-r59usk02 2443 16 previously previously RB cord-014516-r59usk02 2443 17 been be VBN cord-014516-r59usk02 2443 18 described describe VBN cord-014516-r59usk02 2443 19 in in IN cord-014516-r59usk02 2443 20 domestic domestic JJ cord-014516-r59usk02 2443 21 pets pet NNS cord-014516-r59usk02 2443 22 . . . cord-014516-r59usk02 2444 1 A a DT cord-014516-r59usk02 2444 2 six six CD cord-014516-r59usk02 2444 3 year year NN cord-014516-r59usk02 2444 4 old old JJ cord-014516-r59usk02 2444 5 , , , cord-014516-r59usk02 2444 6 de de JJ cord-014516-r59usk02 2444 7 - - JJ cord-014516-r59usk02 2444 8 sexed sexed JJ cord-014516-r59usk02 2444 9 female female JJ cord-014516-r59usk02 2444 10 British british JJ cord-014516-r59usk02 2444 11 Shorthair Shorthair NNP cord-014516-r59usk02 2444 12 cat cat NN cord-014516-r59usk02 2444 13 presented present VBN cord-014516-r59usk02 2444 14 with with IN cord-014516-r59usk02 2444 15 acute acute JJ cord-014516-r59usk02 2444 16 onset onset NN cord-014516-r59usk02 2444 17 weakness weakness NN cord-014516-r59usk02 2444 18 and and CC cord-014516-r59usk02 2444 19 mental mental JJ cord-014516-r59usk02 2444 20 dullness dullness NN cord-014516-r59usk02 2444 21 . . . cord-014516-r59usk02 2445 1 Upon upon IN cord-014516-r59usk02 2445 2 initial initial JJ cord-014516-r59usk02 2445 3 presentation presentation NN cord-014516-r59usk02 2445 4 the the DT cord-014516-r59usk02 2445 5 cat cat NN cord-014516-r59usk02 2445 6 was be VBD cord-014516-r59usk02 2445 7 mildly mildly RB cord-014516-r59usk02 2445 8 hyperglycaemic hyperglycaemic JJ cord-014516-r59usk02 2445 9 ( ( -LRB- cord-014516-r59usk02 2445 10 9.9 9.9 CD cord-014516-r59usk02 2445 11 mmol mmol JJ cord-014516-r59usk02 2445 12 / / SYM cord-014516-r59usk02 2445 13 L l NN cord-014516-r59usk02 2445 14 ; ; : cord-014516-r59usk02 2445 15 3.3 3.3 CD cord-014516-r59usk02 2445 16 - - SYM cord-014516-r59usk02 2445 17 6.7 6.7 CD cord-014516-r59usk02 2445 18 mmol mmol JJ cord-014516-r59usk02 2445 19 / / SYM cord-014516-r59usk02 2445 20 L L NNP cord-014516-r59usk02 2445 21 ) ) -RRB- cord-014516-r59usk02 2445 22 . . . cord-014516-r59usk02 2446 1 Over over IN cord-014516-r59usk02 2446 2 the the DT cord-014516-r59usk02 2446 3 following follow VBG cord-014516-r59usk02 2446 4 12 12 CD cord-014516-r59usk02 2446 5 hours hour NNS cord-014516-r59usk02 2446 6 the the DT cord-014516-r59usk02 2446 7 cat cat NN cord-014516-r59usk02 2446 8 developed develop VBD cord-014516-r59usk02 2446 9 central central JJ cord-014516-r59usk02 2446 10 blindness blindness NN cord-014516-r59usk02 2446 11 , , , cord-014516-r59usk02 2446 12 tremors tremor NNS cord-014516-r59usk02 2446 13 , , , cord-014516-r59usk02 2446 14 intermittent intermittent JJ cord-014516-r59usk02 2446 15 seizures seizure NNS cord-014516-r59usk02 2446 16 and and CC cord-014516-r59usk02 2446 17 opisthotonus opisthotonus NN cord-014516-r59usk02 2446 18 . . . cord-014516-r59usk02 2447 1 Repeat repeat VB cord-014516-r59usk02 2447 2 blood blood NN cord-014516-r59usk02 2447 3 sampling sampling NN cord-014516-r59usk02 2447 4 revealed reveal VBD cord-014516-r59usk02 2447 5 a a DT cord-014516-r59usk02 2447 6 marked marked JJ cord-014516-r59usk02 2447 7 hypoglycaemia hypoglycaemia NN cord-014516-r59usk02 2447 8 ( ( -LRB- cord-014516-r59usk02 2447 9 0.8 0.8 CD cord-014516-r59usk02 2447 10 mmol mmol JJ cord-014516-r59usk02 2447 11 / / SYM cord-014516-r59usk02 2447 12 L L NNP cord-014516-r59usk02 2447 13 ) ) -RRB- cord-014516-r59usk02 2447 14 . . . cord-014516-r59usk02 2448 1 An an DT cord-014516-r59usk02 2448 2 insulin insulin NN cord-014516-r59usk02 2448 3 level level NN cord-014516-r59usk02 2448 4 ( ( -LRB- cord-014516-r59usk02 2448 5 performed perform VBN cord-014516-r59usk02 2448 6 on on IN cord-014516-r59usk02 2448 7 serum serum NN cord-014516-r59usk02 2448 8 obtained obtain VBN cord-014516-r59usk02 2448 9 while while IN cord-014516-r59usk02 2448 10 the the DT cord-014516-r59usk02 2448 11 cat cat NN cord-014516-r59usk02 2448 12 was be VBD cord-014516-r59usk02 2448 13 hypoglycaemic hypoglycaemic JJ cord-014516-r59usk02 2448 14 ) ) -RRB- cord-014516-r59usk02 2448 15 was be VBD cord-014516-r59usk02 2448 16 inappropriately inappropriately RB cord-014516-r59usk02 2448 17 elevated elevate VBN cord-014516-r59usk02 2448 18 ( ( -LRB- cord-014516-r59usk02 2448 19 10938 10938 CD cord-014516-r59usk02 2448 20 pmol pmol NNP cord-014516-r59usk02 2448 21 / / SYM cord-014516-r59usk02 2448 22 L l NN cord-014516-r59usk02 2448 23 ; ; : cord-014516-r59usk02 2448 24 reference reference NN cord-014516-r59usk02 2448 25 range range NN cord-014516-r59usk02 2448 26 72 72 CD cord-014516-r59usk02 2448 27 -583 -583 NN cord-014516-r59usk02 2448 28 pmol pmol NNP cord-014516-r59usk02 2448 29 / / SYM cord-014516-r59usk02 2448 30 L L NNP cord-014516-r59usk02 2448 31 ) ) -RRB- cord-014516-r59usk02 2448 32 . . . cord-014516-r59usk02 2449 1 An an DT cord-014516-r59usk02 2449 2 intravenous intravenous JJ cord-014516-r59usk02 2449 3 bolus bolus NN cord-014516-r59usk02 2449 4 of of IN cord-014516-r59usk02 2449 5 5 5 CD cord-014516-r59usk02 2449 6 % % NN cord-014516-r59usk02 2449 7 glucose glucose NN cord-014516-r59usk02 2449 8 resulted result VBD cord-014516-r59usk02 2449 9 in in IN cord-014516-r59usk02 2449 10 rapid rapid JJ cord-014516-r59usk02 2449 11 resolution resolution NN cord-014516-r59usk02 2449 12 of of IN cord-014516-r59usk02 2449 13 all all DT cord-014516-r59usk02 2449 14 clinical clinical JJ cord-014516-r59usk02 2449 15 signs sign NNS cord-014516-r59usk02 2449 16 and and CC cord-014516-r59usk02 2449 17 mild mild JJ cord-014516-r59usk02 2449 18 transient transient JJ cord-014516-r59usk02 2449 19 hyperglycaemia hyperglycaemia NN cord-014516-r59usk02 2449 20 ( ( -LRB- cord-014516-r59usk02 2449 21 12.5 12.5 CD cord-014516-r59usk02 2449 22 mmol mmol NNP cord-014516-r59usk02 2449 23 / / SYM cord-014516-r59usk02 2449 24 L L NNP cord-014516-r59usk02 2449 25 ) ) -RRB- cord-014516-r59usk02 2449 26 . . . cord-014516-r59usk02 2450 1 Despite despite IN cord-014516-r59usk02 2450 2 frequent frequent JJ cord-014516-r59usk02 2450 3 feeding feeding NN cord-014516-r59usk02 2450 4 , , , cord-014516-r59usk02 2450 5 the the DT cord-014516-r59usk02 2450 6 hypoglycaemia hypoglycaemia NN cord-014516-r59usk02 2450 7 ( ( -LRB- cord-014516-r59usk02 2450 8 2.0 2.0 CD cord-014516-r59usk02 2450 9 mmol mmol NN cord-014516-r59usk02 2450 10 / / SYM cord-014516-r59usk02 2450 11 L L NNP cord-014516-r59usk02 2450 12 ) ) -RRB- cord-014516-r59usk02 2450 13 recurred recur VBD cord-014516-r59usk02 2450 14 , , , cord-014516-r59usk02 2450 15 so so IN cord-014516-r59usk02 2450 16 an an DT cord-014516-r59usk02 2450 17 intravenous intravenous JJ cord-014516-r59usk02 2450 18 glucose glucose NN cord-014516-r59usk02 2450 19 continuous continuous JJ cord-014516-r59usk02 2450 20 rate rate NN cord-014516-r59usk02 2450 21 infusion infusion NN cord-014516-r59usk02 2450 22 was be VBD cord-014516-r59usk02 2450 23 commenced commence VBN cord-014516-r59usk02 2450 24 . . . cord-014516-r59usk02 2451 1 An an DT cord-014516-r59usk02 2451 2 abdominal abdominal JJ cord-014516-r59usk02 2451 3 ultrasound ultrasound NN cord-014516-r59usk02 2451 4 was be VBD cord-014516-r59usk02 2451 5 unremarkable unremarkable JJ cord-014516-r59usk02 2451 6 , , , cord-014516-r59usk02 2451 7 although although IN cord-014516-r59usk02 2451 8 three three CD cord-014516-r59usk02 2451 9 cranial cranial JJ cord-014516-r59usk02 2451 10 mesenteric mesenteric JJ cord-014516-r59usk02 2451 11 lymph lymph NN cord-014516-r59usk02 2451 12 nodes node NNS cord-014516-r59usk02 2451 13 were be VBD cord-014516-r59usk02 2451 14 noted note VBN cord-014516-r59usk02 2451 15 to to TO cord-014516-r59usk02 2451 16 be be VB cord-014516-r59usk02 2451 17 prominent prominent JJ cord-014516-r59usk02 2451 18 ( ( -LRB- cord-014516-r59usk02 2451 19 3 3 CD cord-014516-r59usk02 2451 20 mm mm NN cord-014516-r59usk02 2451 21 in in IN cord-014516-r59usk02 2451 22 width width NN cord-014516-r59usk02 2451 23 ) ) -RRB- cord-014516-r59usk02 2451 24 . . . cord-014516-r59usk02 2452 1 An an DT cord-014516-r59usk02 2452 2 exploratory exploratory JJ cord-014516-r59usk02 2452 3 laparotomy laparotomy NN cord-014516-r59usk02 2452 4 revealed reveal VBD cord-014516-r59usk02 2452 5 a a DT cord-014516-r59usk02 2452 6 firm firm JJ cord-014516-r59usk02 2452 7 and and CC cord-014516-r59usk02 2452 8 erythematous erythematous JJ cord-014516-r59usk02 2452 9 left left JJ cord-014516-r59usk02 2452 10 limb limb NN cord-014516-r59usk02 2452 11 of of IN cord-014516-r59usk02 2452 12 the the DT cord-014516-r59usk02 2452 13 pancreas pancrea NNS cord-014516-r59usk02 2452 14 . . . cord-014516-r59usk02 2453 1 The the DT cord-014516-r59usk02 2453 2 body body NN cord-014516-r59usk02 2453 3 and and CC cord-014516-r59usk02 2453 4 right right JJ cord-014516-r59usk02 2453 5 limb limb NN cord-014516-r59usk02 2453 6 of of IN cord-014516-r59usk02 2453 7 the the DT cord-014516-r59usk02 2453 8 pancreas pancreas NN cord-014516-r59usk02 2453 9 appeared appear VBD cord-014516-r59usk02 2453 10 grossly grossly RB cord-014516-r59usk02 2453 11 normal normal JJ cord-014516-r59usk02 2453 12 . . . cord-014516-r59usk02 2454 1 Following follow VBG cord-014516-r59usk02 2454 2 surgical surgical JJ cord-014516-r59usk02 2454 3 resection resection NN cord-014516-r59usk02 2454 4 of of IN cord-014516-r59usk02 2454 5 the the DT cord-014516-r59usk02 2454 6 left left JJ cord-014516-r59usk02 2454 7 limb limb NN cord-014516-r59usk02 2454 8 of of IN cord-014516-r59usk02 2454 9 the the DT cord-014516-r59usk02 2454 10 pancreas pancreas NN cord-014516-r59usk02 2454 11 , , , cord-014516-r59usk02 2454 12 the the DT cord-014516-r59usk02 2454 13 cat cat NN cord-014516-r59usk02 2454 14 returned return VBD cord-014516-r59usk02 2454 15 to to IN cord-014516-r59usk02 2454 16 a a DT cord-014516-r59usk02 2454 17 euglycaemic euglycaemic NN cord-014516-r59usk02 2454 18 state state NN cord-014516-r59usk02 2454 19 after after IN cord-014516-r59usk02 2454 20 a a DT cord-014516-r59usk02 2454 21 brief brief JJ cord-014516-r59usk02 2454 22 rebound rebound NN cord-014516-r59usk02 2454 23 hyperglycaemia hyperglycaemia NN cord-014516-r59usk02 2454 24 . . . cord-014516-r59usk02 2455 1 Histopathology Histopathology NNP cord-014516-r59usk02 2455 2 revealed reveal VBD cord-014516-r59usk02 2455 3 pancreatic pancreatic JJ cord-014516-r59usk02 2455 4 fibrosis fibrosis NN cord-014516-r59usk02 2455 5 with with IN cord-014516-r59usk02 2455 6 marked marked JJ cord-014516-r59usk02 2455 7 multifocal multifocal JJ cord-014516-r59usk02 2455 8 micronodular micronodular JJ cord-014516-r59usk02 2455 9 hyperplasia hyperplasia NN cord-014516-r59usk02 2455 10 of of IN cord-014516-r59usk02 2455 11 exocrine exocrine JJ cord-014516-r59usk02 2455 12 and and CC cord-014516-r59usk02 2455 13 endocrine endocrine JJ cord-014516-r59usk02 2455 14 cells cell NNS cord-014516-r59usk02 2455 15 , , , cord-014516-r59usk02 2455 16 mild mild JJ cord-014516-r59usk02 2455 17 lymphoplasmacytic lymphoplasmacytic JJ cord-014516-r59usk02 2455 18 inflammation inflammation NN cord-014516-r59usk02 2455 19 and and CC cord-014516-r59usk02 2455 20 ductular ductular NNP cord-014516-r59usk02 2455 21 ectasia ectasia NNP cord-014516-r59usk02 2455 22 . . . cord-014516-r59usk02 2456 1 Synaptophysin Synaptophysin NNP cord-014516-r59usk02 2456 2 immunohistochemistry immunohistochemistry NN cord-014516-r59usk02 2456 3 confirmed confirm VBD cord-014516-r59usk02 2456 4 nodular nodular JJ cord-014516-r59usk02 2456 5 beta beta JJ cord-014516-r59usk02 2456 6 cell cell NN cord-014516-r59usk02 2456 7 hyperplasia hyperplasia NN cord-014516-r59usk02 2456 8 . . . cord-014516-r59usk02 2457 1 Mild mild JJ cord-014516-r59usk02 2457 2 granulomatous granulomatous JJ cord-014516-r59usk02 2457 3 lymphadenitis lymphadenitis NN cord-014516-r59usk02 2457 4 and and CC cord-014516-r59usk02 2457 5 hydropic hydropic NNP cord-014516-r59usk02 2457 6 change change NN cord-014516-r59usk02 2457 7 within within IN cord-014516-r59usk02 2457 8 hepatocytes hepatocyte NNS cord-014516-r59usk02 2457 9 was be VBD cord-014516-r59usk02 2457 10 also also RB cord-014516-r59usk02 2457 11 noted note VBN cord-014516-r59usk02 2457 12 . . . cord-014516-r59usk02 2458 1 The the DT cord-014516-r59usk02 2458 2 cat cat NN cord-014516-r59usk02 2458 3 recovered recover VBD cord-014516-r59usk02 2458 4 uneventfully uneventfully RB cord-014516-r59usk02 2458 5 without without IN cord-014516-r59usk02 2458 6 any any DT cord-014516-r59usk02 2458 7 further further JJ cord-014516-r59usk02 2458 8 intervention intervention NN cord-014516-r59usk02 2458 9 . . . cord-014516-r59usk02 2459 1 It -PRON- PRP cord-014516-r59usk02 2459 2 gained gain VBD cord-014516-r59usk02 2459 3 weight weight NN cord-014516-r59usk02 2459 4 and and CC cord-014516-r59usk02 2459 5 remained remain VBD cord-014516-r59usk02 2459 6 euglycaemic euglycaemic NN cord-014516-r59usk02 2459 7 over over IN cord-014516-r59usk02 2459 8 the the DT cord-014516-r59usk02 2459 9 following follow VBG cord-014516-r59usk02 2459 10 six six CD cord-014516-r59usk02 2459 11 months month NNS cord-014516-r59usk02 2459 12 . . . cord-014516-r59usk02 2460 1 While while IN cord-014516-r59usk02 2460 2 beta beta JJ cord-014516-r59usk02 2460 3 cell cell NN cord-014516-r59usk02 2460 4 hyperplasia hyperplasia NN cord-014516-r59usk02 2460 5 has have VBZ cord-014516-r59usk02 2460 6 been be VBN cord-014516-r59usk02 2460 7 reported report VBN cord-014516-r59usk02 2460 8 as as IN cord-014516-r59usk02 2460 9 an an DT cord-014516-r59usk02 2460 10 incidental incidental JJ cord-014516-r59usk02 2460 11 histopathological histopathological JJ cord-014516-r59usk02 2460 12 finding finding NN cord-014516-r59usk02 2460 13 in in IN cord-014516-r59usk02 2460 14 euglycaemic euglycaemic JJ cord-014516-r59usk02 2460 15 young young JJ cord-014516-r59usk02 2460 16 Beagles Beagles NNPS cord-014516-r59usk02 2460 17 , , , cord-014516-r59usk02 2460 18 this this DT cord-014516-r59usk02 2460 19 is be VBZ cord-014516-r59usk02 2460 20 the the DT cord-014516-r59usk02 2460 21 first first JJ cord-014516-r59usk02 2460 22 reported report VBN cord-014516-r59usk02 2460 23 case case NN cord-014516-r59usk02 2460 24 of of IN cord-014516-r59usk02 2460 25 clinically clinically RB cord-014516-r59usk02 2460 26 significant significant JJ cord-014516-r59usk02 2460 27 hypoglycaemia hypoglycaemia NN cord-014516-r59usk02 2460 28 secondary secondary JJ cord-014516-r59usk02 2460 29 to to IN cord-014516-r59usk02 2460 30 nesidioblastosis nesidioblastosis NN cord-014516-r59usk02 2460 31 in in IN cord-014516-r59usk02 2460 32 a a DT cord-014516-r59usk02 2460 33 domestic domestic JJ cord-014516-r59usk02 2460 34 pet pet NN cord-014516-r59usk02 2460 35 . . . cord-014516-r59usk02 2461 1 While while IN cord-014516-r59usk02 2461 2 this this DT cord-014516-r59usk02 2461 3 condition condition NN cord-014516-r59usk02 2461 4 is be VBZ cord-014516-r59usk02 2461 5 rare rare JJ cord-014516-r59usk02 2461 6 , , , cord-014516-r59usk02 2461 7 nesidioblastosis nesidioblastosis NN cord-014516-r59usk02 2461 8 is be VBZ cord-014516-r59usk02 2461 9 being be VBG cord-014516-r59usk02 2461 10 increasingly increasingly RB cord-014516-r59usk02 2461 11 recognised recognise VBN cord-014516-r59usk02 2461 12 in in IN cord-014516-r59usk02 2461 13 the the DT cord-014516-r59usk02 2461 14 human human JJ cord-014516-r59usk02 2461 15 field field NN cord-014516-r59usk02 2461 16 and and CC cord-014516-r59usk02 2461 17 it -PRON- PRP cord-014516-r59usk02 2461 18 is be VBZ cord-014516-r59usk02 2461 19 an an DT cord-014516-r59usk02 2461 20 important important JJ cord-014516-r59usk02 2461 21 differential differential NN cord-014516-r59usk02 2461 22 to to TO cord-014516-r59usk02 2461 23 consider consider VB cord-014516-r59usk02 2461 24 when when WRB cord-014516-r59usk02 2461 25 investigating investigate VBG cord-014516-r59usk02 2461 26 hypoglycaemia hypoglycaemia NN cord-014516-r59usk02 2461 27 as as IN cord-014516-r59usk02 2461 28 it -PRON- PRP cord-014516-r59usk02 2461 29 can can MD cord-014516-r59usk02 2461 30 not not RB cord-014516-r59usk02 2461 31 be be VB cord-014516-r59usk02 2461 32 differentiated differentiate VBN cord-014516-r59usk02 2461 33 from from IN cord-014516-r59usk02 2461 34 insulinoma insulinoma NN cord-014516-r59usk02 2461 35 without without IN cord-014516-r59usk02 2461 36 histopathological histopathological JJ cord-014516-r59usk02 2461 37 evaluation evaluation NN cord-014516-r59usk02 2461 38 . . . cord-014516-r59usk02 2462 1 Age age NN cord-014516-r59usk02 2462 2 of of IN cord-014516-r59usk02 2462 3 onset onset NN cord-014516-r59usk02 2462 4 may may MD cord-014516-r59usk02 2462 5 provide provide VB cord-014516-r59usk02 2462 6 a a DT cord-014516-r59usk02 2462 7 clue clue NN cord-014516-r59usk02 2462 8 to to IN cord-014516-r59usk02 2462 9 this this DT cord-014516-r59usk02 2462 10 non non JJ cord-014516-r59usk02 2462 11 - - JJ cord-014516-r59usk02 2462 12 neoplastic neoplastic JJ cord-014516-r59usk02 2462 13 disease disease NN cord-014516-r59usk02 2462 14 , , , cord-014516-r59usk02 2462 15 as as IN cord-014516-r59usk02 2462 16 this this DT cord-014516-r59usk02 2462 17 cat cat NN cord-014516-r59usk02 2462 18 was be VBD cord-014516-r59usk02 2462 19 much much RB cord-014516-r59usk02 2462 20 younger young JJR cord-014516-r59usk02 2462 21 than than IN cord-014516-r59usk02 2462 22 all all DT cord-014516-r59usk02 2462 23 previously previously RB cord-014516-r59usk02 2462 24 reported report VBN cord-014516-r59usk02 2462 25 cases case NNS cord-014516-r59usk02 2462 26 of of IN cord-014516-r59usk02 2462 27 feline feline JJ cord-014516-r59usk02 2462 28 insulinoma insulinoma NN cord-014516-r59usk02 2462 29 ( ( -LRB- cord-014516-r59usk02 2462 30 all all DT cord-014516-r59usk02 2462 31 > > XX cord-014516-r59usk02 2462 32 12 12 CD cord-014516-r59usk02 2462 33 years year NNS cord-014516-r59usk02 2462 34 of of IN cord-014516-r59usk02 2462 35 age age NN cord-014516-r59usk02 2462 36 at at IN cord-014516-r59usk02 2462 37 diagnosis diagnosis NN cord-014516-r59usk02 2462 38 ) ) -RRB- cord-014516-r59usk02 2462 39 . . . cord-014516-r59usk02 2463 1 While while IN cord-014516-r59usk02 2463 2 recurrence recurrence NN cord-014516-r59usk02 2463 3 has have VBZ cord-014516-r59usk02 2463 4 been be VBN cord-014516-r59usk02 2463 5 reported report VBN cord-014516-r59usk02 2463 6 in in IN cord-014516-r59usk02 2463 7 humans human NNS cord-014516-r59usk02 2463 8 , , , cord-014516-r59usk02 2463 9 a a DT cord-014516-r59usk02 2463 10 favourable favourable JJ cord-014516-r59usk02 2463 11 outcome outcome NN cord-014516-r59usk02 2463 12 is be VBZ cord-014516-r59usk02 2463 13 anticipated anticipate VBN cord-014516-r59usk02 2463 14 following follow VBG cord-014516-r59usk02 2463 15 partial partial JJ cord-014516-r59usk02 2463 16 pancreatectomy pancreatectomy NN cord-014516-r59usk02 2463 17 . . . cord-014516-r59usk02 2464 1 No no DT cord-014516-r59usk02 2464 2 conflicts conflict NNS cord-014516-r59usk02 2464 3 of of IN cord-014516-r59usk02 2464 4 interest interest NN cord-014516-r59usk02 2464 5 reported report VBN cord-014516-r59usk02 2464 6 . . . cord-014516-r59usk02 2465 1 Hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2465 2 is be VBZ cord-014516-r59usk02 2465 3 the the DT cord-014516-r59usk02 2465 4 most most RBS cord-014516-r59usk02 2465 5 common common JJ cord-014516-r59usk02 2465 6 feline feline JJ cord-014516-r59usk02 2465 7 endocrinopathy endocrinopathy NN cord-014516-r59usk02 2465 8 of of IN cord-014516-r59usk02 2465 9 geriatric geriatric JJ cord-014516-r59usk02 2465 10 cats cat NNS cord-014516-r59usk02 2465 11 worldwide worldwide RB cord-014516-r59usk02 2465 12 . . . cord-014516-r59usk02 2466 1 Nonetheless nonetheless RB cord-014516-r59usk02 2466 2 , , , cord-014516-r59usk02 2466 3 data datum NNS cord-014516-r59usk02 2466 4 concerning concern VBG cord-014516-r59usk02 2466 5 the the DT cord-014516-r59usk02 2466 6 accurate accurate JJ cord-014516-r59usk02 2466 7 prevalence prevalence NN cord-014516-r59usk02 2466 8 of of IN cord-014516-r59usk02 2466 9 feline feline JJ cord-014516-r59usk02 2466 10 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2466 11 ( ( -LRB- cord-014516-r59usk02 2466 12 FH FH NNP cord-014516-r59usk02 2466 13 ) ) -RRB- cord-014516-r59usk02 2466 14 is be VBZ cord-014516-r59usk02 2466 15 scarce scarce JJ cord-014516-r59usk02 2466 16 ; ; : cord-014516-r59usk02 2466 17 and and CC cord-014516-r59usk02 2466 18 apparently apparently RB cord-014516-r59usk02 2466 19 exhibit exhibit VB cord-014516-r59usk02 2466 20 geographical geographical JJ cord-014516-r59usk02 2466 21 variation variation NN cord-014516-r59usk02 2466 22 , , , cord-014516-r59usk02 2466 23 which which WDT cord-014516-r59usk02 2466 24 can can MD cord-014516-r59usk02 2466 25 be be VB cord-014516-r59usk02 2466 26 an an DT cord-014516-r59usk02 2466 27 important important JJ cord-014516-r59usk02 2466 28 instrument instrument NN cord-014516-r59usk02 2466 29 in in IN cord-014516-r59usk02 2466 30 investigating investigate VBG cord-014516-r59usk02 2466 31 risk risk NN cord-014516-r59usk02 2466 32 factors factor NNS cord-014516-r59usk02 2466 33 through through IN cord-014516-r59usk02 2466 34 the the DT cord-014516-r59usk02 2466 35 analysis analysis NN cord-014516-r59usk02 2466 36 of of IN cord-014516-r59usk02 2466 37 exposure exposure NN cord-014516-r59usk02 2466 38 to to IN cord-014516-r59usk02 2466 39 different different JJ cord-014516-r59usk02 2466 40 factors factor NNS cord-014516-r59usk02 2466 41 in in IN cord-014516-r59usk02 2466 42 areas area NNS cord-014516-r59usk02 2466 43 of of IN cord-014516-r59usk02 2466 44 high high JJ cord-014516-r59usk02 2466 45 and and CC cord-014516-r59usk02 2466 46 low low JJ cord-014516-r59usk02 2466 47 prevalence prevalence NN cord-014516-r59usk02 2466 48 . . . cord-014516-r59usk02 2467 1 In in IN cord-014516-r59usk02 2467 2 Europe Europe NNP cord-014516-r59usk02 2467 3 , , , cord-014516-r59usk02 2467 4 FH FH NNP cord-014516-r59usk02 2467 5 is be VBZ cord-014516-r59usk02 2467 6 considered consider VBN cord-014516-r59usk02 2467 7 more more RBR cord-014516-r59usk02 2467 8 frequent frequent JJ cord-014516-r59usk02 2467 9 in in IN cord-014516-r59usk02 2467 10 the the DT cord-014516-r59usk02 2467 11 northern northern JJ cord-014516-r59usk02 2467 12 than than IN cord-014516-r59usk02 2467 13 in in IN cord-014516-r59usk02 2467 14 the the DT cord-014516-r59usk02 2467 15 southern southern JJ cord-014516-r59usk02 2467 16 countries country NNS cord-014516-r59usk02 2467 17 . . . cord-014516-r59usk02 2468 1 The the DT cord-014516-r59usk02 2468 2 aims aim NNS cord-014516-r59usk02 2468 3 of of IN cord-014516-r59usk02 2468 4 this this DT cord-014516-r59usk02 2468 5 study study NN cord-014516-r59usk02 2468 6 were be VBD cord-014516-r59usk02 2468 7 to to TO cord-014516-r59usk02 2468 8 determine determine VB cord-014516-r59usk02 2468 9 the the DT cord-014516-r59usk02 2468 10 occurrence occurrence NN cord-014516-r59usk02 2468 11 of of IN cord-014516-r59usk02 2468 12 FH FH NNP cord-014516-r59usk02 2468 13 in in IN cord-014516-r59usk02 2468 14 a a DT cord-014516-r59usk02 2468 15 region region NN cord-014516-r59usk02 2468 16 of of IN cord-014516-r59usk02 2468 17 Portugal Portugal NNP cord-014516-r59usk02 2468 18 , , , cord-014516-r59usk02 2468 19 to to TO cord-014516-r59usk02 2468 20 characterize characterize VB cord-014516-r59usk02 2468 21 clinical clinical JJ cord-014516-r59usk02 2468 22 presentation presentation NN cord-014516-r59usk02 2468 23 and and CC cord-014516-r59usk02 2468 24 potential potential JJ cord-014516-r59usk02 2468 25 risk risk NN cord-014516-r59usk02 2468 26 factors factor NNS cord-014516-r59usk02 2468 27 . . . cord-014516-r59usk02 2469 1 During during IN cord-014516-r59usk02 2469 2 an an DT cord-014516-r59usk02 2469 3 18-month 18-month JJ cord-014516-r59usk02 2469 4 period period NN cord-014516-r59usk02 2469 5 , , , cord-014516-r59usk02 2469 6 120 120 CD cord-014516-r59usk02 2469 7 geriatric geriatric JJ cord-014516-r59usk02 2469 8 cats cat NNS cord-014516-r59usk02 2469 9 ≥ ≥ CD cord-014516-r59usk02 2469 10 eight eight CD cord-014516-r59usk02 2469 11 years year NNS cord-014516-r59usk02 2469 12 from from IN cord-014516-r59usk02 2469 13 Aveiro Aveiro NNP cord-014516-r59usk02 2469 14 ( ( -LRB- cord-014516-r59usk02 2469 15 Central central JJ cord-014516-r59usk02 2469 16 region region NN cord-014516-r59usk02 2469 17 of of IN cord-014516-r59usk02 2469 18 Portugal Portugal NNP cord-014516-r59usk02 2469 19 ) ) -RRB- cord-014516-r59usk02 2469 20 were be VBD cord-014516-r59usk02 2469 21 selected select VBN cord-014516-r59usk02 2469 22 . . . cord-014516-r59usk02 2470 1 Cats cat NNS cord-014516-r59usk02 2470 2 were be VBD cord-014516-r59usk02 2470 3 excluded exclude VBN cord-014516-r59usk02 2470 4 if if IN cord-014516-r59usk02 2470 5 presented present VBN cord-014516-r59usk02 2470 6 in in IN cord-014516-r59usk02 2470 7 shock shock NN cord-014516-r59usk02 2470 8 or or CC cord-014516-r59usk02 2470 9 moribund moribund JJ cord-014516-r59usk02 2470 10 , , , cord-014516-r59usk02 2470 11 or or CC cord-014516-r59usk02 2470 12 in in IN cord-014516-r59usk02 2470 13 treatment treatment NN cord-014516-r59usk02 2470 14 with with IN cord-014516-r59usk02 2470 15 drugs drug NNS cord-014516-r59usk02 2470 16 that that WDT cord-014516-r59usk02 2470 17 might may MD cord-014516-r59usk02 2470 18 affect affect VB cord-014516-r59usk02 2470 19 total total JJ cord-014516-r59usk02 2470 20 T4 T4 NNP cord-014516-r59usk02 2470 21 ( ( -LRB- cord-014516-r59usk02 2470 22 TT4 TT4 NNP cord-014516-r59usk02 2470 23 ) ) -RRB- cord-014516-r59usk02 2470 24 serum serum NN cord-014516-r59usk02 2470 25 concentration concentration NN cord-014516-r59usk02 2470 26 . . . cord-014516-r59usk02 2471 1 The the DT cord-014516-r59usk02 2471 2 TT4 TT4 NNP cord-014516-r59usk02 2471 3 concentration concentration NN cord-014516-r59usk02 2471 4 was be VBD cord-014516-r59usk02 2471 5 determined determine VBN cord-014516-r59usk02 2471 6 through through IN cord-014516-r59usk02 2471 7 chemiluminescence chemiluminescence NN cord-014516-r59usk02 2471 8 ( ( -LRB- cord-014516-r59usk02 2471 9 Immulite Immulite NNP cord-014516-r59usk02 2471 10 â â NNP cord-014516-r59usk02 2471 11 , , , cord-014516-r59usk02 2471 12 Siemens Siemens NNP cord-014516-r59usk02 2471 13 ) ) -RRB- cord-014516-r59usk02 2471 14 , , , cord-014516-r59usk02 2471 15 and and CC cord-014516-r59usk02 2471 16 diagnosis diagnosis NN cord-014516-r59usk02 2471 17 of of IN cord-014516-r59usk02 2471 18 FH FH NNP cord-014516-r59usk02 2471 19 established establish VBN cord-014516-r59usk02 2471 20 if if IN cord-014516-r59usk02 2471 21 TT4 TT4 NNP cord-014516-r59usk02 2471 22 serum serum NN cord-014516-r59usk02 2471 23 concentration concentration NN cord-014516-r59usk02 2471 24 ≥ ≥ CD cord-014516-r59usk02 2471 25 4.0 4.0 CD cord-014516-r59usk02 2471 26 lg lg NNP cord-014516-r59usk02 2471 27 / / SYM cord-014516-r59usk02 2471 28 dl dl NN cord-014516-r59usk02 2471 29 ( ( -LRB- cord-014516-r59usk02 2471 30 reference reference NN cord-014516-r59usk02 2471 31 values value VBZ cord-014516-r59usk02 2471 32 0.8 0.8 CD cord-014516-r59usk02 2471 33 - - HYPH cord-014516-r59usk02 2471 34 3.9 3.9 CD cord-014516-r59usk02 2471 35 lg lg NNP cord-014516-r59usk02 2471 36 / / SYM cord-014516-r59usk02 2471 37 dl dl NN cord-014516-r59usk02 2471 38 ) ) -RRB- cord-014516-r59usk02 2471 39 associated associate VBN cord-014516-r59usk02 2471 40 with with IN cord-014516-r59usk02 2471 41 compatible compatible JJ cord-014516-r59usk02 2471 42 clinical clinical JJ cord-014516-r59usk02 2471 43 signs sign NNS cord-014516-r59usk02 2471 44 . . . cord-014516-r59usk02 2472 1 Information information NN cord-014516-r59usk02 2472 2 on on IN cord-014516-r59usk02 2472 3 age age NN cord-014516-r59usk02 2472 4 , , , cord-014516-r59usk02 2472 5 gender gender NN cord-014516-r59usk02 2472 6 , , , cord-014516-r59usk02 2472 7 breed breed NN cord-014516-r59usk02 2472 8 , , , cord-014516-r59usk02 2472 9 weight weight NN cord-014516-r59usk02 2472 10 , , , cord-014516-r59usk02 2472 11 housing housing NN cord-014516-r59usk02 2472 12 conditions condition NNS cord-014516-r59usk02 2472 13 ( ( -LRB- cord-014516-r59usk02 2472 14 indoor indoor JJ cord-014516-r59usk02 2472 15 vs vs IN cord-014516-r59usk02 2472 16 outdoor outdoor JJ cord-014516-r59usk02 2472 17 ) ) -RRB- cord-014516-r59usk02 2472 18 , , , cord-014516-r59usk02 2472 19 use use NN cord-014516-r59usk02 2472 20 of of IN cord-014516-r59usk02 2472 21 external external JJ cord-014516-r59usk02 2472 22 parasiticides parasiticide NNS cord-014516-r59usk02 2472 23 , , , cord-014516-r59usk02 2472 24 food food NN cord-014516-r59usk02 2472 25 ( ( -LRB- cord-014516-r59usk02 2472 26 dry dry JJ cord-014516-r59usk02 2472 27 vs vs IN cord-014516-r59usk02 2472 28 canned canned JJ cord-014516-r59usk02 2472 29 food food NN cord-014516-r59usk02 2472 30 and and CC cord-014516-r59usk02 2472 31 flavor flavor NN cord-014516-r59usk02 2472 32 ) ) -RRB- cord-014516-r59usk02 2472 33 , , , cord-014516-r59usk02 2472 34 use use NN cord-014516-r59usk02 2472 35 of of IN cord-014516-r59usk02 2472 36 litter litter NN cord-014516-r59usk02 2472 37 box box NN cord-014516-r59usk02 2472 38 , , , cord-014516-r59usk02 2472 39 environment environment NN cord-014516-r59usk02 2472 40 , , , cord-014516-r59usk02 2472 41 clinical clinical JJ cord-014516-r59usk02 2472 42 signs sign NNS cord-014516-r59usk02 2472 43 and and CC cord-014516-r59usk02 2472 44 laboratory laboratory NN cord-014516-r59usk02 2472 45 data datum NNS cord-014516-r59usk02 2472 46 was be VBD cord-014516-r59usk02 2472 47 collected collect VBN cord-014516-r59usk02 2472 48 . . . cord-014516-r59usk02 2473 1 All all DT cord-014516-r59usk02 2473 2 owners owner NNS cord-014516-r59usk02 2473 3 gave give VBD cord-014516-r59usk02 2473 4 informed informed JJ cord-014516-r59usk02 2473 5 consent consent NN cord-014516-r59usk02 2473 6 . . . cord-014516-r59usk02 2474 1 Population population NN cord-014516-r59usk02 2474 2 studied study VBD cord-014516-r59usk02 2474 3 included include VBD cord-014516-r59usk02 2474 4 49 49 CD cord-014516-r59usk02 2474 5 males male NNS cord-014516-r59usk02 2474 6 ( ( -LRB- cord-014516-r59usk02 2474 7 40.8 40.8 CD cord-014516-r59usk02 2474 8 % % NN cord-014516-r59usk02 2474 9 ) ) -RRB- cord-014516-r59usk02 2474 10 and and CC cord-014516-r59usk02 2474 11 71 71 CD cord-014516-r59usk02 2474 12 females female NNS cord-014516-r59usk02 2474 13 ( ( -LRB- cord-014516-r59usk02 2474 14 59.2 59.2 CD cord-014516-r59usk02 2474 15 % % NN cord-014516-r59usk02 2474 16 ) ) -RRB- cord-014516-r59usk02 2474 17 , , , cord-014516-r59usk02 2474 18 mainly mainly RB cord-014516-r59usk02 2474 19 domestic domestic JJ cord-014516-r59usk02 2474 20 short short JJ cord-014516-r59usk02 2474 21 - - HYPH cord-014516-r59usk02 2474 22 haired haired JJ cord-014516-r59usk02 2474 23 cats cat NNS cord-014516-r59usk02 2474 24 ( ( -LRB- cord-014516-r59usk02 2474 25 88.3 88.3 CD cord-014516-r59usk02 2474 26 % % NN cord-014516-r59usk02 2474 27 ) ) -RRB- cord-014516-r59usk02 2474 28 . . . cord-014516-r59usk02 2475 1 Ages age NNS cord-014516-r59usk02 2475 2 ranged range VBD cord-014516-r59usk02 2475 3 from from IN cord-014516-r59usk02 2475 4 eight eight CD cord-014516-r59usk02 2475 5 to to TO cord-014516-r59usk02 2475 6 21 21 CD cord-014516-r59usk02 2475 7 years year NNS cord-014516-r59usk02 2475 8 old old JJ cord-014516-r59usk02 2475 9 ( ( -LRB- cord-014516-r59usk02 2475 10 11.8 11.8 CD cord-014516-r59usk02 2475 11 + + CC cord-014516-r59usk02 2475 12 /-3.0 /-3.0 NN cord-014516-r59usk02 2475 13 ) ) -RRB- cord-014516-r59usk02 2475 14 . . . cord-014516-r59usk02 2476 1 Eight eight CD cord-014516-r59usk02 2476 2 ( ( -LRB- cord-014516-r59usk02 2476 3 6.7 6.7 CD cord-014516-r59usk02 2476 4 % % NN cord-014516-r59usk02 2476 5 ) ) -RRB- cord-014516-r59usk02 2476 6 cats cat NNS cord-014516-r59usk02 2476 7 were be VBD cord-014516-r59usk02 2476 8 diagnosed diagnose VBN cord-014516-r59usk02 2476 9 with with IN cord-014516-r59usk02 2476 10 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2476 11 . . . cord-014516-r59usk02 2477 1 If if IN cord-014516-r59usk02 2477 2 only only JJ cord-014516-r59usk02 2477 3 cats cat NNS cord-014516-r59usk02 2477 4 ≥ ≥ CD cord-014516-r59usk02 2477 5 10 10 CD cord-014516-r59usk02 2477 6 years year NNS cord-014516-r59usk02 2477 7 of of IN cord-014516-r59usk02 2477 8 age age NN cord-014516-r59usk02 2477 9 were be VBD cord-014516-r59usk02 2477 10 considered consider VBN cord-014516-r59usk02 2477 11 ( ( -LRB- cord-014516-r59usk02 2477 12 n n NN cord-014516-r59usk02 2477 13 = = SYM cord-014516-r59usk02 2477 14 89 89 CD cord-014516-r59usk02 2477 15 ) ) -RRB- cord-014516-r59usk02 2477 16 , , , cord-014516-r59usk02 2477 17 prevalence prevalence NN cord-014516-r59usk02 2477 18 raised raise VBN cord-014516-r59usk02 2477 19 to to IN cord-014516-r59usk02 2477 20 9.0 9.0 CD cord-014516-r59usk02 2477 21 % % NN cord-014516-r59usk02 2477 22 . . . cord-014516-r59usk02 2478 1 Hyperthyroid Hyperthyroid NNP cord-014516-r59usk02 2478 2 population population NN cord-014516-r59usk02 2478 3 comprised comprise VBD cord-014516-r59usk02 2478 4 four four CD cord-014516-r59usk02 2478 5 males male NNS cord-014516-r59usk02 2478 6 and and CC cord-014516-r59usk02 2478 7 four four CD cord-014516-r59usk02 2478 8 females female NNS cord-014516-r59usk02 2478 9 , , , cord-014516-r59usk02 2478 10 ranging range VBG cord-014516-r59usk02 2478 11 from from IN cord-014516-r59usk02 2478 12 13 13 CD cord-014516-r59usk02 2478 13 to to TO cord-014516-r59usk02 2478 14 21 21 CD cord-014516-r59usk02 2478 15 years year NNS cord-014516-r59usk02 2478 16 old old JJ cord-014516-r59usk02 2478 17 ( ( -LRB- cord-014516-r59usk02 2478 18 15.6 15.6 CD cord-014516-r59usk02 2478 19 + + CC cord-014516-r59usk02 2478 20 /-2.7 /-2.7 . cord-014516-r59usk02 2478 21 ) ) -RRB- cord-014516-r59usk02 2478 22 . . . cord-014516-r59usk02 2479 1 Increasing increase VBG cord-014516-r59usk02 2479 2 age age NN cord-014516-r59usk02 2479 3 ( ( -LRB- cord-014516-r59usk02 2479 4 p p NN cord-014516-r59usk02 2479 5 = = SYM cord-014516-r59usk02 2479 6 0.001 0.001 CD cord-014516-r59usk02 2479 7 ) ) -RRB- cord-014516-r59usk02 2479 8 , , , cord-014516-r59usk02 2479 9 polyphagia polyphagia NNP cord-014516-r59usk02 2479 10 ( ( -LRB- cord-014516-r59usk02 2479 11 p˂0.001 p˂0.001 NNP cord-014516-r59usk02 2479 12 ) ) -RRB- cord-014516-r59usk02 2479 13 , , , cord-014516-r59usk02 2479 14 weight weight NN cord-014516-r59usk02 2479 15 loss loss NN cord-014516-r59usk02 2479 16 associated associate VBN cord-014516-r59usk02 2479 17 with with IN cord-014516-r59usk02 2479 18 increased increase VBN cord-014516-r59usk02 2479 19 ( ( -LRB- cord-014516-r59usk02 2479 20 p˂0.001 p˂0.001 NNP cord-014516-r59usk02 2479 21 ) ) -RRB- cord-014516-r59usk02 2479 22 or or CC cord-014516-r59usk02 2479 23 normal normal JJ cord-014516-r59usk02 2479 24 appetite appetite NN cord-014516-r59usk02 2479 25 ( ( -LRB- cord-014516-r59usk02 2479 26 p˂0.001 p˂0.001 NNP cord-014516-r59usk02 2479 27 ) ) -RRB- cord-014516-r59usk02 2479 28 , , , cord-014516-r59usk02 2479 29 presence presence NN cord-014516-r59usk02 2479 30 of of IN cord-014516-r59usk02 2479 31 thyroid thyroid NN cord-014516-r59usk02 2479 32 uni uni NN cord-014516-r59usk02 2479 33 or or CC cord-014516-r59usk02 2479 34 bilateral bilateral JJ cord-014516-r59usk02 2479 35 nodules nodule NNS cord-014516-r59usk02 2479 36 ( ( -LRB- cord-014516-r59usk02 2479 37 p˂0.001 p˂0.001 NNP cord-014516-r59usk02 2479 38 ) ) -RRB- cord-014516-r59usk02 2479 39 , , , cord-014516-r59usk02 2479 40 vomiting vomit VBG cord-014516-r59usk02 2479 41 ( ( -LRB- cord-014516-r59usk02 2479 42 p p NN cord-014516-r59usk02 2479 43 = = SYM cord-014516-r59usk02 2479 44 0.04 0.04 CD cord-014516-r59usk02 2479 45 ) ) -RRB- cord-014516-r59usk02 2479 46 and and CC cord-014516-r59usk02 2479 47 hyperactivity hyperactivity NN cord-014516-r59usk02 2479 48 ( ( -LRB- cord-014516-r59usk02 2479 49 p p NN cord-014516-r59usk02 2479 50 = = SYM cord-014516-r59usk02 2479 51 0.006 0.006 CD cord-014516-r59usk02 2479 52 ) ) -RRB- cord-014516-r59usk02 2479 53 were be VBD cord-014516-r59usk02 2479 54 significantly significantly RB cord-014516-r59usk02 2479 55 associated associate VBN cord-014516-r59usk02 2479 56 with with IN cord-014516-r59usk02 2479 57 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2479 58 in in IN cord-014516-r59usk02 2479 59 the the DT cord-014516-r59usk02 2479 60 geriatric geriatric JJ cord-014516-r59usk02 2479 61 population population NN cord-014516-r59usk02 2479 62 studied study VBD cord-014516-r59usk02 2479 63 . . . cord-014516-r59usk02 2480 1 Environment environment NN cord-014516-r59usk02 2480 2 was be VBD cord-014516-r59usk02 2480 3 also also RB cord-014516-r59usk02 2480 4 significantly significantly RB cord-014516-r59usk02 2480 5 associated associate VBN cord-014516-r59usk02 2480 6 with with IN cord-014516-r59usk02 2480 7 development development NN cord-014516-r59usk02 2480 8 of of IN cord-014516-r59usk02 2480 9 FH FH NNP cord-014516-r59usk02 2480 10 ( ( -LRB- cord-014516-r59usk02 2480 11 p˂0.001 p˂0.001 NNP cord-014516-r59usk02 2480 12 ) ) -RRB- cord-014516-r59usk02 2480 13 , , , cord-014516-r59usk02 2480 14 with with IN cord-014516-r59usk02 2480 15 cats cat NNS cord-014516-r59usk02 2480 16 from from IN cord-014516-r59usk02 2480 17 urban urban JJ cord-014516-r59usk02 2480 18 or or CC cord-014516-r59usk02 2480 19 semi semi JJ cord-014516-r59usk02 2480 20 - - JJ cord-014516-r59usk02 2480 21 rural rural JJ cord-014516-r59usk02 2480 22 areas area NNS cord-014516-r59usk02 2480 23 at at IN cord-014516-r59usk02 2480 24 higher high JJR cord-014516-r59usk02 2480 25 risk risk NN cord-014516-r59usk02 2480 26 of of IN cord-014516-r59usk02 2480 27 developing develop VBG cord-014516-r59usk02 2480 28 the the DT cord-014516-r59usk02 2480 29 disease disease NN cord-014516-r59usk02 2480 30 than than IN cord-014516-r59usk02 2480 31 cats cat NNS cord-014516-r59usk02 2480 32 living live VBG cord-014516-r59usk02 2480 33 in in IN cord-014516-r59usk02 2480 34 a a DT cord-014516-r59usk02 2480 35 rural rural JJ cord-014516-r59usk02 2480 36 environment environment NN cord-014516-r59usk02 2480 37 . . . cord-014516-r59usk02 2481 1 No no DT cord-014516-r59usk02 2481 2 other other JJ cord-014516-r59usk02 2481 3 significant significant JJ cord-014516-r59usk02 2481 4 associations association NNS cord-014516-r59usk02 2481 5 were be VBD cord-014516-r59usk02 2481 6 found find VBN cord-014516-r59usk02 2481 7 between between IN cord-014516-r59usk02 2481 8 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2481 9 and and CC cord-014516-r59usk02 2481 10 other other JJ cord-014516-r59usk02 2481 11 factors factor NNS cord-014516-r59usk02 2481 12 analyzed analyze VBN cord-014516-r59usk02 2481 13 . . . cord-014516-r59usk02 2482 1 In in IN cord-014516-r59usk02 2482 2 our -PRON- PRP$ cord-014516-r59usk02 2482 3 knowledge knowledge NN cord-014516-r59usk02 2482 4 , , , cord-014516-r59usk02 2482 5 no no DT cord-014516-r59usk02 2482 6 epidemiologic epidemiologic JJ cord-014516-r59usk02 2482 7 studies study NNS cord-014516-r59usk02 2482 8 on on IN cord-014516-r59usk02 2482 9 FH FH NNP cord-014516-r59usk02 2482 10 have have VBP cord-014516-r59usk02 2482 11 been be VBN cord-014516-r59usk02 2482 12 performed perform VBN cord-014516-r59usk02 2482 13 in in IN cord-014516-r59usk02 2482 14 Portugal Portugal NNP cord-014516-r59usk02 2482 15 , , , cord-014516-r59usk02 2482 16 a a DT cord-014516-r59usk02 2482 17 country country NN cord-014516-r59usk02 2482 18 where where WRB cord-014516-r59usk02 2482 19 the the DT cord-014516-r59usk02 2482 20 occurrence occurrence NN cord-014516-r59usk02 2482 21 is be VBZ cord-014516-r59usk02 2482 22 believed believe VBN cord-014516-r59usk02 2482 23 to to TO cord-014516-r59usk02 2482 24 be be VB cord-014516-r59usk02 2482 25 low low JJ cord-014516-r59usk02 2482 26 , , , cord-014516-r59usk02 2482 27 but but CC cord-014516-r59usk02 2482 28 in in IN cord-014516-r59usk02 2482 29 which which WDT cord-014516-r59usk02 2482 30 the the DT cord-014516-r59usk02 2482 31 population population NN cord-014516-r59usk02 2482 32 of of IN cord-014516-r59usk02 2482 33 pet pet JJ cord-014516-r59usk02 2482 34 cats cat NNS cord-014516-r59usk02 2482 35 , , , cord-014516-r59usk02 2482 36 the the DT cord-014516-r59usk02 2482 37 feline feline JJ cord-014516-r59usk02 2482 38 geriatric geriatric JJ cord-014516-r59usk02 2482 39 population population NN cord-014516-r59usk02 2482 40 and and CC cord-014516-r59usk02 2482 41 the the DT cord-014516-r59usk02 2482 42 clinical clinical JJ cord-014516-r59usk02 2482 43 cases case NNS cord-014516-r59usk02 2482 44 diagnosed diagnose VBN cord-014516-r59usk02 2482 45 have have VBP cord-014516-r59usk02 2482 46 been be VBN cord-014516-r59usk02 2482 47 increasing increase VBG cord-014516-r59usk02 2482 48 . . . cord-014516-r59usk02 2483 1 Conflicts conflict NNS cord-014516-r59usk02 2483 2 of of IN cord-014516-r59usk02 2483 3 interest interest NN cord-014516-r59usk02 2483 4 : : : cord-014516-r59usk02 2483 5 The the DT cord-014516-r59usk02 2483 6 study study NN cord-014516-r59usk02 2483 7 was be VBD cord-014516-r59usk02 2483 8 partially partially RB cord-014516-r59usk02 2483 9 supported support VBN cord-014516-r59usk02 2483 10 by by IN cord-014516-r59usk02 2483 11 Laborat Laborat NNP cord-014516-r59usk02 2483 12 orio orio NNP cord-014516-r59usk02 2483 13 Segalab Segalab NNP cord-014516-r59usk02 2483 14 S.A. S.A. NNP cord-014516-r59usk02 2483 15 and and CC cord-014516-r59usk02 2483 16 Dechra Dechra NNP cord-014516-r59usk02 2483 17 Veterinary Veterinary NNP cord-014516-r59usk02 2483 18 Products Products NNPS cord-014516-r59usk02 2483 19 . . . cord-014516-r59usk02 2484 1 Canine canine JJ cord-014516-r59usk02 2484 2 diabetes diabetes NN cord-014516-r59usk02 2484 3 mellitus mellitus NN cord-014516-r59usk02 2484 4 ( ( -LRB- cord-014516-r59usk02 2484 5 cDM cdm NN cord-014516-r59usk02 2484 6 ) ) -RRB- cord-014516-r59usk02 2484 7 has have VBZ cord-014516-r59usk02 2484 8 been be VBN cord-014516-r59usk02 2484 9 proposed propose VBN cord-014516-r59usk02 2484 10 to to TO cord-014516-r59usk02 2484 11 be be VB cord-014516-r59usk02 2484 12 a a DT cord-014516-r59usk02 2484 13 spontaneous spontaneous JJ cord-014516-r59usk02 2484 14 animal animal NN cord-014516-r59usk02 2484 15 model model NN cord-014516-r59usk02 2484 16 of of IN cord-014516-r59usk02 2484 17 human human JJ cord-014516-r59usk02 2484 18 autoimmune autoimmune JJ cord-014516-r59usk02 2484 19 diabetes diabetes NN cord-014516-r59usk02 2484 20 , , , cord-014516-r59usk02 2484 21 and and CC cord-014516-r59usk02 2484 22 comparative comparative JJ cord-014516-r59usk02 2484 23 research research NN cord-014516-r59usk02 2484 24 can can MD cord-014516-r59usk02 2484 25 be be VB cord-014516-r59usk02 2484 26 undertaken undertake VBN cord-014516-r59usk02 2484 27 to to TO cord-014516-r59usk02 2484 28 investigate investigate VB cord-014516-r59usk02 2484 29 the the DT cord-014516-r59usk02 2484 30 interaction interaction NN cord-014516-r59usk02 2484 31 between between IN cord-014516-r59usk02 2484 32 genetic genetic JJ cord-014516-r59usk02 2484 33 and and CC cord-014516-r59usk02 2484 34 environmental environmental JJ cord-014516-r59usk02 2484 35 factors factor NNS cord-014516-r59usk02 2484 36 . . . cord-014516-r59usk02 2485 1 Most Most JJS cord-014516-r59usk02 2485 2 epidemiological epidemiological JJ cord-014516-r59usk02 2485 3 studies study NNS cord-014516-r59usk02 2485 4 of of IN cord-014516-r59usk02 2485 5 cDM cDM NNP cord-014516-r59usk02 2485 6 have have VBP cord-014516-r59usk02 2485 7 been be VBN cord-014516-r59usk02 2485 8 performed perform VBN cord-014516-r59usk02 2485 9 in in IN cord-014516-r59usk02 2485 10 northern northern JJ cord-014516-r59usk02 2485 11 European european JJ cord-014516-r59usk02 2485 12 and and CC cord-014516-r59usk02 2485 13 North north JJ cord-014516-r59usk02 2485 14 American american JJ cord-014516-r59usk02 2485 15 populations population NNS cord-014516-r59usk02 2485 16 . . . cord-014516-r59usk02 2486 1 Our -PRON- PRP$ cord-014516-r59usk02 2486 2 aim aim NN cord-014516-r59usk02 2486 3 was be VBD cord-014516-r59usk02 2486 4 to to TO cord-014516-r59usk02 2486 5 evaluate evaluate VB cord-014516-r59usk02 2486 6 the the DT cord-014516-r59usk02 2486 7 epidemiology epidemiology NN cord-014516-r59usk02 2486 8 and and CC cord-014516-r59usk02 2486 9 clinical clinical JJ cord-014516-r59usk02 2486 10 features feature NNS cord-014516-r59usk02 2486 11 of of IN cord-014516-r59usk02 2486 12 the the DT cord-014516-r59usk02 2486 13 diabetic diabetic JJ cord-014516-r59usk02 2486 14 dog dog NN cord-014516-r59usk02 2486 15 population population NN cord-014516-r59usk02 2486 16 from from IN cord-014516-r59usk02 2486 17 the the DT cord-014516-r59usk02 2486 18 Canary Canary NNP cord-014516-r59usk02 2486 19 Islands Islands NNPS cord-014516-r59usk02 2486 20 , , , cord-014516-r59usk02 2486 21 with with IN cord-014516-r59usk02 2486 22 special special JJ cord-014516-r59usk02 2486 23 focus focus NN cord-014516-r59usk02 2486 24 on on IN cord-014516-r59usk02 2486 25 immune immune NN cord-014516-r59usk02 2486 26 - - HYPH cord-014516-r59usk02 2486 27 mediated mediate VBN cord-014516-r59usk02 2486 28 disease disease NN cord-014516-r59usk02 2486 29 . . . cord-014516-r59usk02 2487 1 Dogs dog NNS cord-014516-r59usk02 2487 2 attending attend VBG cord-014516-r59usk02 2487 3 our -PRON- PRP$ cord-014516-r59usk02 2487 4 Veterinary Veterinary NNP cord-014516-r59usk02 2487 5 Teaching Teaching NNP cord-014516-r59usk02 2487 6 Hospital Hospital NNP cord-014516-r59usk02 2487 7 were be VBD cord-014516-r59usk02 2487 8 included include VBN cord-014516-r59usk02 2487 9 from from IN cord-014516-r59usk02 2487 10 January January NNP cord-014516-r59usk02 2487 11 2009 2009 CD cord-014516-r59usk02 2487 12 to to IN cord-014516-r59usk02 2487 13 January January NNP cord-014516-r59usk02 2487 14 2012 2012 CD cord-014516-r59usk02 2487 15 . . . cord-014516-r59usk02 2488 1 Previously previously RB cord-014516-r59usk02 2488 2 diagnosed diagnose VBN cord-014516-r59usk02 2488 3 and and CC cord-014516-r59usk02 2488 4 new new JJ cord-014516-r59usk02 2488 5 cases case NNS cord-014516-r59usk02 2488 6 were be VBD cord-014516-r59usk02 2488 7 considered consider VBN cord-014516-r59usk02 2488 8 . . . cord-014516-r59usk02 2489 1 Prevalence prevalence NN cord-014516-r59usk02 2489 2 was be VBD cord-014516-r59usk02 2489 3 calculated calculate VBN cord-014516-r59usk02 2489 4 as as IN cord-014516-r59usk02 2489 5 number number NN cord-014516-r59usk02 2489 6 of of IN cord-014516-r59usk02 2489 7 cDM cdm NN cord-014516-r59usk02 2489 8 / / SYM cord-014516-r59usk02 2489 9 total total JJ cord-014516-r59usk02 2489 10 number number NN cord-014516-r59usk02 2489 11 of of IN cord-014516-r59usk02 2489 12 dogs dog NNS cord-014516-r59usk02 2489 13 attending attend VBG cord-014516-r59usk02 2489 14 the the DT cord-014516-r59usk02 2489 15 hospital hospital NN cord-014516-r59usk02 2489 16 and and CC cord-014516-r59usk02 2489 17 incidence incidence NN cord-014516-r59usk02 2489 18 as as IN cord-014516-r59usk02 2489 19 newly newly RB cord-014516-r59usk02 2489 20 diagnosed diagnose VBN cord-014516-r59usk02 2489 21 cases case NNS cord-014516-r59usk02 2489 22 divided divide VBN cord-014516-r59usk02 2489 23 by by IN cord-014516-r59usk02 2489 24 the the DT cord-014516-r59usk02 2489 25 same same JJ cord-014516-r59usk02 2489 26 value value NN cord-014516-r59usk02 2489 27 per per IN cord-014516-r59usk02 2489 28 year year NN cord-014516-r59usk02 2489 29 . . . cord-014516-r59usk02 2490 1 Anti anti JJ cord-014516-r59usk02 2490 2 - - JJ cord-014516-r59usk02 2490 3 insulin insulin JJ cord-014516-r59usk02 2490 4 antibodies antibody NNS cord-014516-r59usk02 2490 5 were be VBD cord-014516-r59usk02 2490 6 assessed assess VBN cord-014516-r59usk02 2490 7 by by IN cord-014516-r59usk02 2490 8 ELISA ELISA NNP cord-014516-r59usk02 2490 9 . . . cord-014516-r59usk02 2491 1 Genotyping genotype VBG cord-014516-r59usk02 2491 2 for for IN cord-014516-r59usk02 2491 3 dog dog NN cord-014516-r59usk02 2491 4 leukocyte leukocyte NN cord-014516-r59usk02 2491 5 antigen antigen NN cord-014516-r59usk02 2491 6 ( ( -LRB- cord-014516-r59usk02 2491 7 DLA DLA NNP cord-014516-r59usk02 2491 8 ) ) -RRB- cord-014516-r59usk02 2492 1 and and CC cord-014516-r59usk02 2492 2 measurement measurement NN cord-014516-r59usk02 2492 3 of of IN cord-014516-r59usk02 2492 4 canine canine JJ cord-014516-r59usk02 2492 5 anti anti NNS cord-014516-r59usk02 2492 6 - - JJ cord-014516-r59usk02 2492 7 GAD65 GAD65 NNP cord-014516-r59usk02 2492 8 and and CC cord-014516-r59usk02 2492 9 anti anti JJ cord-014516-r59usk02 2492 10 - - JJ cord-014516-r59usk02 2492 11 IA2 ia2 JJ cord-014516-r59usk02 2492 12 antibodies antibody NNS cord-014516-r59usk02 2492 13 by by IN cord-014516-r59usk02 2492 14 radio radio NN cord-014516-r59usk02 2492 15 - - HYPH cord-014516-r59usk02 2492 16 immunoprecipitation immunoprecipitation NN cord-014516-r59usk02 2492 17 assay assay NN cord-014516-r59usk02 2492 18 were be VBD cord-014516-r59usk02 2492 19 performed perform VBN cord-014516-r59usk02 2492 20 in in IN cord-014516-r59usk02 2492 21 dogs dog NNS cord-014516-r59usk02 2492 22 with with IN cord-014516-r59usk02 2492 23 suspected suspect VBN cord-014516-r59usk02 2492 24 immune immune NN cord-014516-r59usk02 2492 25 - - HYPH cord-014516-r59usk02 2492 26 mediated mediate VBN cord-014516-r59usk02 2492 27 diabetes diabetes NN cord-014516-r59usk02 2492 28 . . . cord-014516-r59usk02 2493 1 Twenty twenty CD cord-014516-r59usk02 2493 2 - - HYPH cord-014516-r59usk02 2493 3 nine nine CD cord-014516-r59usk02 2493 4 dogs dog NNS cord-014516-r59usk02 2493 5 with with IN cord-014516-r59usk02 2493 6 cDM cdm NN cord-014516-r59usk02 2493 7 were be VBD cord-014516-r59usk02 2493 8 identified identify VBN cord-014516-r59usk02 2493 9 from from IN cord-014516-r59usk02 2493 10 a a DT cord-014516-r59usk02 2493 11 mean mean JJ cord-014516-r59usk02 2493 12 population population NN cord-014516-r59usk02 2493 13 of of IN cord-014516-r59usk02 2493 14 4302 4302 CD cord-014516-r59usk02 2493 15 ( ( -LRB- cord-014516-r59usk02 2493 16 3741 3741 CD cord-014516-r59usk02 2493 17 - - SYM cord-014516-r59usk02 2493 18 4581 4581 CD cord-014516-r59usk02 2493 19 ) ) -RRB- cord-014516-r59usk02 2493 20 dogs dog NNS cord-014516-r59usk02 2493 21 per per IN cord-014516-r59usk02 2493 22 year year NN cord-014516-r59usk02 2493 23 ( ( -LRB- cord-014516-r59usk02 2493 24 mean mean VB cord-014516-r59usk02 2493 25 prevalence prevalence NN cord-014516-r59usk02 2493 26 0.23 0.23 CD cord-014516-r59usk02 2493 27 % % NN cord-014516-r59usk02 2493 28 and and CC cord-014516-r59usk02 2493 29 mean mean VB cord-014516-r59usk02 2493 30 incidence incidence NN cord-014516-r59usk02 2493 31 cases case NNS cord-014516-r59usk02 2493 32 per per IN cord-014516-r59usk02 2493 33 year year NN cord-014516-r59usk02 2493 34 16 16 CD cord-014516-r59usk02 2493 35 per per IN cord-014516-r59usk02 2493 36 10,000 10,000 CD cord-014516-r59usk02 2493 37 ) ) -RRB- cord-014516-r59usk02 2493 38 . . . cord-014516-r59usk02 2494 1 Age age NN cord-014516-r59usk02 2494 2 at at IN cord-014516-r59usk02 2494 3 diagnosis diagnosis NN cord-014516-r59usk02 2494 4 was be VBD cord-014516-r59usk02 2494 5 9.45 9.45 CD cord-014516-r59usk02 2494 6 years year NNS cord-014516-r59usk02 2495 1 ( ( -LRB- cord-014516-r59usk02 2495 2 range range NN cord-014516-r59usk02 2495 3 : : : cord-014516-r59usk02 2495 4 3.5 3.5 CD cord-014516-r59usk02 2495 5 - - HYPH cord-014516-r59usk02 2495 6 14y 14y CD cord-014516-r59usk02 2495 7 ) ) -RRB- cord-014516-r59usk02 2495 8 . . . cord-014516-r59usk02 2496 1 Most Most JJS cord-014516-r59usk02 2496 2 dogs dog NNS cord-014516-r59usk02 2496 3 were be VBD cord-014516-r59usk02 2496 4 not not RB cord-014516-r59usk02 2496 5 neutered neutered JJ cord-014516-r59usk02 2496 6 ( ( -LRB- cord-014516-r59usk02 2496 7 87 87 CD cord-014516-r59usk02 2496 8 % % NN cord-014516-r59usk02 2496 9 females female NNS cord-014516-r59usk02 2496 10 ; ; : cord-014516-r59usk02 2496 11 83 83 CD cord-014516-r59usk02 2496 12 % % NN cord-014516-r59usk02 2496 13 males male NNS cord-014516-r59usk02 2496 14 ) ) -RRB- cord-014516-r59usk02 2496 15 . . . cord-014516-r59usk02 2497 1 Nine nine CD cord-014516-r59usk02 2497 2 breeds breed NNS cord-014516-r59usk02 2497 3 were be VBD cord-014516-r59usk02 2497 4 represented represent VBN cord-014516-r59usk02 2497 5 , , , cord-014516-r59usk02 2497 6 including include VBG cord-014516-r59usk02 2497 7 Poodle Poodle NNP cord-014516-r59usk02 2497 8 ( ( -LRB- cord-014516-r59usk02 2497 9 21 21 CD cord-014516-r59usk02 2497 10 % % NN cord-014516-r59usk02 2497 11 ) ) -RRB- cord-014516-r59usk02 2497 12 and and CC cord-014516-r59usk02 2497 13 Andalusian andalusian JJ cord-014516-r59usk02 2497 14 wine wine NN cord-014516-r59usk02 2497 15 - - HYPH cord-014516-r59usk02 2497 16 cellar cellar NN cord-014516-r59usk02 2497 17 rathunting rathunting NN cord-014516-r59usk02 2497 18 dog dog NN cord-014516-r59usk02 2497 19 ( ( -LRB- cord-014516-r59usk02 2497 20 7 7 CD cord-014516-r59usk02 2497 21 % % NN cord-014516-r59usk02 2497 22 ) ) -RRB- cord-014516-r59usk02 2497 23 . . . cord-014516-r59usk02 2498 1 Seasonality seasonality NN cord-014516-r59usk02 2498 2 was be VBD cord-014516-r59usk02 2498 3 observed observe VBN cord-014516-r59usk02 2498 4 in in IN cord-014516-r59usk02 2498 5 the the DT cord-014516-r59usk02 2498 6 diagnosis diagnosis NN cord-014516-r59usk02 2498 7 with with IN cord-014516-r59usk02 2498 8 peaks peak NNS cord-014516-r59usk02 2498 9 in in IN cord-014516-r59usk02 2498 10 December December NNP cord-014516-r59usk02 2498 11 and and CC cord-014516-r59usk02 2498 12 March March NNP cord-014516-r59usk02 2498 13 - - HYPH cord-014516-r59usk02 2498 14 April April NNP cord-014516-r59usk02 2498 15 . . . cord-014516-r59usk02 2499 1 Diabetes diabetes NN cord-014516-r59usk02 2499 2 was be VBD cord-014516-r59usk02 2499 3 classified classify VBN cord-014516-r59usk02 2499 4 as as IN cord-014516-r59usk02 2499 5 dioestrus dioestrus NNP cord-014516-r59usk02 2499 6 diabetes diabetes NNP cord-014516-r59usk02 2499 7 ( ( -LRB- cord-014516-r59usk02 2499 8 55 55 CD cord-014516-r59usk02 2499 9 % % NN cord-014516-r59usk02 2499 10 ) ) -RRB- cord-014516-r59usk02 2499 11 , , , cord-014516-r59usk02 2499 12 idiopathic idiopathic JJ cord-014516-r59usk02 2499 13 / / SYM cord-014516-r59usk02 2499 14 immune immune NN cord-014516-r59usk02 2499 15 - - HYPH cord-014516-r59usk02 2499 16 mediated mediate VBN cord-014516-r59usk02 2499 17 ( ( -LRB- cord-014516-r59usk02 2499 18 21 21 CD cord-014516-r59usk02 2499 19 % % NN cord-014516-r59usk02 2499 20 ) ) -RRB- cord-014516-r59usk02 2499 21 , , , cord-014516-r59usk02 2499 22 iatrogenic iatrogenic JJ cord-014516-r59usk02 2499 23 ( ( -LRB- cord-014516-r59usk02 2499 24 7 7 CD cord-014516-r59usk02 2499 25 % % NN cord-014516-r59usk02 2499 26 ) ) -RRB- cord-014516-r59usk02 2499 27 and and CC cord-014516-r59usk02 2499 28 secondary secondary JJ cord-014516-r59usk02 2499 29 to to IN cord-014516-r59usk02 2499 30 pancreatitis pancreatitis NN cord-014516-r59usk02 2499 31 ( ( -LRB- cord-014516-r59usk02 2499 32 14 14 CD cord-014516-r59usk02 2499 33 % % NN cord-014516-r59usk02 2499 34 ) ) -RRB- cord-014516-r59usk02 2499 35 or or CC cord-014516-r59usk02 2499 36 other other JJ cord-014516-r59usk02 2499 37 endocrine endocrine JJ cord-014516-r59usk02 2499 38 disorders disorder NNS cord-014516-r59usk02 2499 39 ( ( -LRB- cord-014516-r59usk02 2499 40 3 3 CD cord-014516-r59usk02 2499 41 % % NN cord-014516-r59usk02 2499 42 ) ) -RRB- cord-014516-r59usk02 2499 43 . . . cord-014516-r59usk02 2500 1 Insulin insulin NN cord-014516-r59usk02 2500 2 - - HYPH cord-014516-r59usk02 2500 3 treated treat VBN cord-014516-r59usk02 2500 4 dogs dog NNS cord-014516-r59usk02 2500 5 were be VBD cord-014516-r59usk02 2500 6 negative negative JJ cord-014516-r59usk02 2500 7 for for IN cord-014516-r59usk02 2500 8 anti anti JJ cord-014516-r59usk02 2500 9 - - JJ cord-014516-r59usk02 2500 10 insulin insulin JJ cord-014516-r59usk02 2500 11 antibodies antibody NNS cord-014516-r59usk02 2500 12 ( ( -LRB- cord-014516-r59usk02 2500 13 n n NN cord-014516-r59usk02 2500 14 = = SYM cord-014516-r59usk02 2500 15 19 19 CD cord-014516-r59usk02 2500 16 ) ) -RRB- cord-014516-r59usk02 2500 17 . . . cord-014516-r59usk02 2501 1 From from IN cord-014516-r59usk02 2501 2 the the DT cord-014516-r59usk02 2501 3 suspected suspect VBN cord-014516-r59usk02 2501 4 immune immune NN cord-014516-r59usk02 2501 5 - - HYPH cord-014516-r59usk02 2501 6 mediated mediate VBN cord-014516-r59usk02 2501 7 cases case NNS cord-014516-r59usk02 2501 8 ( ( -LRB- cord-014516-r59usk02 2501 9 n n NN cord-014516-r59usk02 2501 10 = = SYM cord-014516-r59usk02 2501 11 5 5 CD cord-014516-r59usk02 2501 12 ) ) -RRB- cord-014516-r59usk02 2501 13 , , , cord-014516-r59usk02 2501 14 autoantibody autoantibody NNP cord-014516-r59usk02 2501 15 reactivity reactivity NNP cord-014516-r59usk02 2501 16 was be VBD cord-014516-r59usk02 2501 17 shown show VBN cord-014516-r59usk02 2501 18 in in IN cord-014516-r59usk02 2501 19 two two CD cord-014516-r59usk02 2501 20 cases case NNS cord-014516-r59usk02 2501 21 ( ( -LRB- cord-014516-r59usk02 2501 22 anti anti NNS cord-014516-r59usk02 2501 23 - - JJ cord-014516-r59usk02 2501 24 GAD65 GAD65 NNP cord-014516-r59usk02 2501 25 , , , cord-014516-r59usk02 2501 26 n n NN cord-014516-r59usk02 2501 27 = = SYM cord-014516-r59usk02 2501 28 1 1 CD cord-014516-r59usk02 2501 29 ; ; : cord-014516-r59usk02 2501 30 anti anti JJ cord-014516-r59usk02 2501 31 - - JJ cord-014516-r59usk02 2501 32 IA2 ia2 JJ cord-014516-r59usk02 2501 33 , , , cord-014516-r59usk02 2501 34 n n NN cord-014516-r59usk02 2501 35 = = SYM cord-014516-r59usk02 2501 36 1 1 CD cord-014516-r59usk02 2501 37 ) ) -RRB- cord-014516-r59usk02 2501 38 . . . cord-014516-r59usk02 2502 1 No no DT cord-014516-r59usk02 2502 2 previously previously RB cord-014516-r59usk02 2502 3 described describe VBN cord-014516-r59usk02 2502 4 , , , cord-014516-r59usk02 2502 5 diabetes diabetes NN cord-014516-r59usk02 2502 6 - - HYPH cord-014516-r59usk02 2502 7 risk risk NN cord-014516-r59usk02 2502 8 DLA dla NN cord-014516-r59usk02 2502 9 - - HYPH cord-014516-r59usk02 2502 10 types type NNS cord-014516-r59usk02 2502 11 were be VBD cord-014516-r59usk02 2502 12 identified identify VBN cord-014516-r59usk02 2502 13 . . . cord-014516-r59usk02 2503 1 Although although IN cord-014516-r59usk02 2503 2 age age NN cord-014516-r59usk02 2503 3 , , , cord-014516-r59usk02 2503 4 prevalence prevalence NN cord-014516-r59usk02 2503 5 and and CC cord-014516-r59usk02 2503 6 incidence incidence NN cord-014516-r59usk02 2503 7 did do VBD cord-014516-r59usk02 2503 8 not not RB cord-014516-r59usk02 2503 9 differ differ VB cord-014516-r59usk02 2503 10 from from IN cord-014516-r59usk02 2503 11 previous previous JJ cord-014516-r59usk02 2503 12 studies study NNS cord-014516-r59usk02 2503 13 , , , cord-014516-r59usk02 2503 14 the the DT cord-014516-r59usk02 2503 15 high high JJ cord-014516-r59usk02 2503 16 proportion proportion NN cord-014516-r59usk02 2503 17 of of IN cord-014516-r59usk02 2503 18 entire entire JJ cord-014516-r59usk02 2503 19 females female NNS cord-014516-r59usk02 2503 20 likely likely RB cord-014516-r59usk02 2503 21 explained explain VBD cord-014516-r59usk02 2503 22 the the DT cord-014516-r59usk02 2503 23 high high JJ cord-014516-r59usk02 2503 24 frequency frequency NN cord-014516-r59usk02 2503 25 of of IN cord-014516-r59usk02 2503 26 dioestrus dioestrus NNP cord-014516-r59usk02 2503 27 diabetes diabete NNS cord-014516-r59usk02 2503 28 . . . cord-014516-r59usk02 2504 1 The the DT cord-014516-r59usk02 2504 2 Andalusian andalusian JJ cord-014516-r59usk02 2504 3 wine wine NN cord-014516-r59usk02 2504 4 - - HYPH cord-014516-r59usk02 2504 5 cellar cellar NN cord-014516-r59usk02 2504 6 rat rat NN cord-014516-r59usk02 2504 7 - - HYPH cord-014516-r59usk02 2504 8 hunting hunting NN cord-014516-r59usk02 2504 9 dog dog NN cord-014516-r59usk02 2504 10 was be VBD cord-014516-r59usk02 2504 11 identified identify VBN cord-014516-r59usk02 2504 12 as as IN cord-014516-r59usk02 2504 13 a a DT cord-014516-r59usk02 2504 14 high high JJ cord-014516-r59usk02 2504 15 - - HYPH cord-014516-r59usk02 2504 16 risk risk NN cord-014516-r59usk02 2504 17 breed breed NN cord-014516-r59usk02 2504 18 for for IN cord-014516-r59usk02 2504 19 cDM cdm NN cord-014516-r59usk02 2504 20 . . . cord-014516-r59usk02 2505 1 Most Most JJS cord-014516-r59usk02 2505 2 of of IN cord-014516-r59usk02 2505 3 the the DT cord-014516-r59usk02 2505 4 DLA DLA NNP cord-014516-r59usk02 2505 5 - - HYPH cord-014516-r59usk02 2505 6 types type NNS cord-014516-r59usk02 2505 7 seen see VBN cord-014516-r59usk02 2505 8 have have VBP cord-014516-r59usk02 2505 9 not not RB cord-014516-r59usk02 2505 10 been be VBN cord-014516-r59usk02 2505 11 previously previously RB cord-014516-r59usk02 2505 12 described describe VBN cord-014516-r59usk02 2505 13 , , , cord-014516-r59usk02 2505 14 but but CC cord-014516-r59usk02 2505 15 at at RB cord-014516-r59usk02 2505 16 least least JJS cord-014516-r59usk02 2505 17 two two CD cord-014516-r59usk02 2505 18 have have VBP cord-014516-r59usk02 2505 19 been be VBN cord-014516-r59usk02 2505 20 associated associate VBN cord-014516-r59usk02 2505 21 with with IN cord-014516-r59usk02 2505 22 increased increase VBN cord-014516-r59usk02 2505 23 risk risk NN cord-014516-r59usk02 2505 24 of of IN cord-014516-r59usk02 2505 25 autoimmunity autoimmunity NN cord-014516-r59usk02 2505 26 in in IN cord-014516-r59usk02 2505 27 dogs dog NNS cord-014516-r59usk02 2505 28 . . . cord-014516-r59usk02 2506 1 Further further JJ cord-014516-r59usk02 2506 2 population population NN cord-014516-r59usk02 2506 3 - - HYPH cord-014516-r59usk02 2506 4 based base VBN cord-014516-r59usk02 2506 5 studies study NNS cord-014516-r59usk02 2506 6 are be VBP cord-014516-r59usk02 2506 7 needed need VBN cord-014516-r59usk02 2506 8 in in IN cord-014516-r59usk02 2506 9 different different JJ cord-014516-r59usk02 2506 10 regions region NNS cord-014516-r59usk02 2506 11 , , , cord-014516-r59usk02 2506 12 to to TO cord-014516-r59usk02 2506 13 assess assess VB cord-014516-r59usk02 2506 14 the the DT cord-014516-r59usk02 2506 15 heterogeneous heterogeneous JJ cord-014516-r59usk02 2506 16 nature nature NN cord-014516-r59usk02 2506 17 of of IN cord-014516-r59usk02 2506 18 this this DT cord-014516-r59usk02 2506 19 disease disease NN cord-014516-r59usk02 2506 20 . . . cord-014516-r59usk02 2507 1 No no DT cord-014516-r59usk02 2507 2 conflicts conflict NNS cord-014516-r59usk02 2507 3 of of IN cord-014516-r59usk02 2507 4 interest interest NN cord-014516-r59usk02 2507 5 reported report VBN cord-014516-r59usk02 2507 6 . . . cord-014516-r59usk02 2508 1 The the DT cord-014516-r59usk02 2508 2 cortisol cortisol NN cord-014516-r59usk02 2508 3 - - HYPH cord-014516-r59usk02 2508 4 dehydroepiandrosterone dehydroepiandrosterone JJ cord-014516-r59usk02 2508 5 ( ( -LRB- cord-014516-r59usk02 2508 6 DHEA)-ratio DHEA)-ratio NNP cord-014516-r59usk02 2508 7 is be VBZ cord-014516-r59usk02 2508 8 widely widely RB cord-014516-r59usk02 2508 9 used use VBN cord-014516-r59usk02 2508 10 in in IN cord-014516-r59usk02 2508 11 human human JJ cord-014516-r59usk02 2508 12 medicine medicine NN cord-014516-r59usk02 2508 13 as as IN cord-014516-r59usk02 2508 14 a a DT cord-014516-r59usk02 2508 15 marker marker NN cord-014516-r59usk02 2508 16 for for IN cord-014516-r59usk02 2508 17 stress stress NN cord-014516-r59usk02 2509 1 however however RB cord-014516-r59usk02 2509 2 it -PRON- PRP cord-014516-r59usk02 2509 3 is be VBZ cord-014516-r59usk02 2509 4 not not RB cord-014516-r59usk02 2509 5 clear clear JJ cord-014516-r59usk02 2509 6 whether whether IN cord-014516-r59usk02 2509 7 it -PRON- PRP cord-014516-r59usk02 2509 8 could could MD cord-014516-r59usk02 2509 9 also also RB cord-014516-r59usk02 2509 10 help help VB cord-014516-r59usk02 2509 11 in in IN cord-014516-r59usk02 2509 12 distinguishing distinguish VBG cord-014516-r59usk02 2509 13 hyperadrenocorticism hyperadrenocorticism NN cord-014516-r59usk02 2509 14 ( ( -LRB- cord-014516-r59usk02 2509 15 HAC HAC NNP cord-014516-r59usk02 2509 16 ) ) -RRB- cord-014516-r59usk02 2509 17 from from IN cord-014516-r59usk02 2509 18 other other JJ cord-014516-r59usk02 2509 19 diseases disease NNS cord-014516-r59usk02 2509 20 which which WDT cord-014516-r59usk02 2509 21 might may MD cord-014516-r59usk02 2509 22 have have VB cord-014516-r59usk02 2509 23 a a DT cord-014516-r59usk02 2509 24 negative negative JJ cord-014516-r59usk02 2509 25 impact impact NN cord-014516-r59usk02 2509 26 on on IN cord-014516-r59usk02 2509 27 the the DT cord-014516-r59usk02 2509 28 outcome outcome NN cord-014516-r59usk02 2509 29 of of IN cord-014516-r59usk02 2509 30 a a DT cord-014516-r59usk02 2509 31 dexamethasone dexamethasone NN cord-014516-r59usk02 2509 32 low low JJ cord-014516-r59usk02 2509 33 dose dose NN cord-014516-r59usk02 2509 34 test test NN cord-014516-r59usk02 2509 35 . . . cord-014516-r59usk02 2510 1 Therefore therefore RB cord-014516-r59usk02 2510 2 the the DT cord-014516-r59usk02 2510 3 aim aim NN cord-014516-r59usk02 2510 4 of of IN cord-014516-r59usk02 2510 5 the the DT cord-014516-r59usk02 2510 6 study study NN cord-014516-r59usk02 2510 7 was be VBD cord-014516-r59usk02 2510 8 to to TO cord-014516-r59usk02 2510 9 evaluate evaluate VB cord-014516-r59usk02 2510 10 the the DT cord-014516-r59usk02 2510 11 cortisol cortisol NN cord-014516-r59usk02 2510 12 - - HYPH cord-014516-r59usk02 2510 13 DHEA dhea NN cord-014516-r59usk02 2510 14 - - HYPH cord-014516-r59usk02 2510 15 ratio ratio NN cord-014516-r59usk02 2510 16 as as IN cord-014516-r59usk02 2510 17 an an DT cord-014516-r59usk02 2510 18 additional additional JJ cord-014516-r59usk02 2510 19 diagnostic diagnostic JJ cord-014516-r59usk02 2510 20 marker marker NN cord-014516-r59usk02 2510 21 for for IN cord-014516-r59usk02 2510 22 HAC HAC NNP cord-014516-r59usk02 2510 23 in in IN cord-014516-r59usk02 2510 24 dogs dog NNS cord-014516-r59usk02 2510 25 . . . cord-014516-r59usk02 2511 1 To to TO cord-014516-r59usk02 2511 2 achieve achieve VB cord-014516-r59usk02 2511 3 this this DT cord-014516-r59usk02 2511 4 aim aim NN cord-014516-r59usk02 2511 5 , , , cord-014516-r59usk02 2511 6 a a DT cord-014516-r59usk02 2511 7 reference reference NN cord-014516-r59usk02 2511 8 range range NN cord-014516-r59usk02 2511 9 of of IN cord-014516-r59usk02 2511 10 this this DT cord-014516-r59usk02 2511 11 ratio ratio NN cord-014516-r59usk02 2511 12 depending depend VBG cord-014516-r59usk02 2511 13 on on IN cord-014516-r59usk02 2511 14 the the DT cord-014516-r59usk02 2511 15 sex sex NN cord-014516-r59usk02 2511 16 should should MD cord-014516-r59usk02 2511 17 be be VB cord-014516-r59usk02 2511 18 evaluated evaluate VBN cord-014516-r59usk02 2511 19 in in IN cord-014516-r59usk02 2511 20 healthy healthy JJ cord-014516-r59usk02 2511 21 dogs dog NNS cord-014516-r59usk02 2511 22 and and CC cord-014516-r59usk02 2511 23 compared compare VBN cord-014516-r59usk02 2511 24 with with IN cord-014516-r59usk02 2511 25 dogs dog NNS cord-014516-r59usk02 2511 26 having have VBG cord-014516-r59usk02 2511 27 a a DT cord-014516-r59usk02 2511 28 HAC HAC NNP cord-014516-r59usk02 2511 29 . . . cord-014516-r59usk02 2512 1 In in IN cord-014516-r59usk02 2512 2 55 55 CD cord-014516-r59usk02 2512 3 healthy healthy JJ cord-014516-r59usk02 2512 4 dogs dog NNS cord-014516-r59usk02 2512 5 ( ( -LRB- cord-014516-r59usk02 2512 6 age age NN cord-014516-r59usk02 2512 7 : : : cord-014516-r59usk02 2512 8 1 1 CD cord-014516-r59usk02 2512 9 -11.4 -11.4 CD cord-014516-r59usk02 2512 10 years year NNS cord-014516-r59usk02 2512 11 ) ) -RRB- cord-014516-r59usk02 2512 12 and and CC cord-014516-r59usk02 2512 13 in in IN cord-014516-r59usk02 2512 14 20 20 CD cord-014516-r59usk02 2512 15 dogs dog NNS cord-014516-r59usk02 2512 16 with with IN cord-014516-r59usk02 2512 17 HAC HAC NNP cord-014516-r59usk02 2512 18 ( ( -LRB- cord-014516-r59usk02 2512 19 age age NN cord-014516-r59usk02 2512 20 : : : cord-014516-r59usk02 2512 21 7.1 7.1 CD cord-014516-r59usk02 2512 22 -14.6 -14.6 CD cord-014516-r59usk02 2512 23 years year NNS cord-014516-r59usk02 2512 24 ) ) -RRB- cord-014516-r59usk02 2512 25 of of IN cord-014516-r59usk02 2512 26 different different JJ cord-014516-r59usk02 2512 27 breeds breed NNS cord-014516-r59usk02 2512 28 the the DT cord-014516-r59usk02 2512 29 plasma plasma NN cord-014516-r59usk02 2512 30 concentration concentration NN cord-014516-r59usk02 2512 31 of of IN cord-014516-r59usk02 2512 32 cortisol cortisol NN cord-014516-r59usk02 2512 33 ( ( -LRB- cord-014516-r59usk02 2512 34 Immulite Immulite NNP cord-014516-r59usk02 2512 35 System System NNP cord-014516-r59usk02 2512 36 , , , cord-014516-r59usk02 2512 37 Siemens Siemens NNP cord-014516-r59usk02 2512 38 Healthcare Healthcare NNP cord-014516-r59usk02 2512 39 Diagnostics Diagnostics NNPS cord-014516-r59usk02 2512 40 ) ) -RRB- cord-014516-r59usk02 2512 41 and and CC cord-014516-r59usk02 2512 42 DHEA DHEA NNP cord-014516-r59usk02 2512 43 ( ( -LRB- cord-014516-r59usk02 2512 44 Beckman Beckman NNP cord-014516-r59usk02 2512 45 Coulter Coulter NNP cord-014516-r59usk02 2512 46 ) ) -RRB- cord-014516-r59usk02 2512 47 was be VBD cord-014516-r59usk02 2512 48 measured measure VBN cord-014516-r59usk02 2512 49 and and CC cord-014516-r59usk02 2512 50 the the DT cord-014516-r59usk02 2512 51 ratio ratio NN cord-014516-r59usk02 2512 52 was be VBD cord-014516-r59usk02 2512 53 calculated calculate VBN cord-014516-r59usk02 2512 54 . . . cord-014516-r59usk02 2513 1 All all DT cord-014516-r59usk02 2513 2 dogs dog NNS cord-014516-r59usk02 2513 3 were be VBD cord-014516-r59usk02 2513 4 patients patient NNS cord-014516-r59usk02 2513 5 of of IN cord-014516-r59usk02 2513 6 the the DT cord-014516-r59usk02 2513 7 Small Small NNP cord-014516-r59usk02 2513 8 Animal Animal NNP cord-014516-r59usk02 2513 9 Clinic Clinic NNP cord-014516-r59usk02 2513 10 except except IN cord-014516-r59usk02 2513 11 five five CD cord-014516-r59usk02 2513 12 of of IN cord-014516-r59usk02 2513 13 the the DT cord-014516-r59usk02 2513 14 healthy healthy JJ cord-014516-r59usk02 2513 15 dogs dog NNS cord-014516-r59usk02 2513 16 which which WDT cord-014516-r59usk02 2513 17 were be VBD cord-014516-r59usk02 2513 18 recruited recruit VBN cord-014516-r59usk02 2513 19 from from IN cord-014516-r59usk02 2513 20 the the DT cord-014516-r59usk02 2513 21 Institute Institute NNP cord-014516-r59usk02 2513 22 of of IN cord-014516-r59usk02 2513 23 Pharmacology Pharmacology NNP cord-014516-r59usk02 2513 24 , , , cord-014516-r59usk02 2513 25 Toxicology Toxicology NNP cord-014516-r59usk02 2513 26 and and CC cord-014516-r59usk02 2513 27 Pharmacy Pharmacy NNP cord-014516-r59usk02 2513 28 of of IN cord-014516-r59usk02 2513 29 the the DT cord-014516-r59usk02 2513 30 University University NNP cord-014516-r59usk02 2513 31 . . . cord-014516-r59usk02 2514 1 With with IN cord-014516-r59usk02 2514 2 these these DT cord-014516-r59usk02 2514 3 data datum NNS cord-014516-r59usk02 2514 4 the the DT cord-014516-r59usk02 2514 5 cortisol cortisol NN cord-014516-r59usk02 2514 6 - - HYPH cord-014516-r59usk02 2514 7 DHEA dhea NN cord-014516-r59usk02 2514 8 - - HYPH cord-014516-r59usk02 2514 9 ratio ratio NN cord-014516-r59usk02 2514 10 was be VBD cord-014516-r59usk02 2514 11 calculated calculate VBN cord-014516-r59usk02 2514 12 for for IN cord-014516-r59usk02 2514 13 male male JJ cord-014516-r59usk02 2514 14 dogs dog NNS cord-014516-r59usk02 2514 15 ( ( -LRB- cord-014516-r59usk02 2514 16 healthy healthy JJ cord-014516-r59usk02 2514 17 dogs dog NNS cord-014516-r59usk02 2514 18 n n CC cord-014516-r59usk02 2514 19 = = SYM cord-014516-r59usk02 2514 20 18 18 CD cord-014516-r59usk02 2514 21 ; ; : cord-014516-r59usk02 2514 22 dogs dog NNS cord-014516-r59usk02 2514 23 with with IN cord-014516-r59usk02 2514 24 HAC HAC NNP cord-014516-r59usk02 2514 25 n n NN cord-014516-r59usk02 2514 26 = = SYM cord-014516-r59usk02 2514 27 3 3 CD cord-014516-r59usk02 2514 28 ) ) -RRB- cord-014516-r59usk02 2514 29 , , , cord-014516-r59usk02 2514 30 neutered neuter VBN cord-014516-r59usk02 2514 31 males male NNS cord-014516-r59usk02 2514 32 ( ( -LRB- cord-014516-r59usk02 2514 33 healthy healthy JJ cord-014516-r59usk02 2514 34 dogs dog NNS cord-014516-r59usk02 2514 35 n n CC cord-014516-r59usk02 2514 36 = = NN cord-014516-r59usk02 2514 37 9 9 CD cord-014516-r59usk02 2514 38 ; ; : cord-014516-r59usk02 2514 39 dogs dog NNS cord-014516-r59usk02 2514 40 with with IN cord-014516-r59usk02 2514 41 HAC HAC NNP cord-014516-r59usk02 2514 42 n n NN cord-014516-r59usk02 2514 43 = = SYM cord-014516-r59usk02 2514 44 5 5 CD cord-014516-r59usk02 2514 45 ) ) -RRB- cord-014516-r59usk02 2514 46 , , , cord-014516-r59usk02 2514 47 female female JJ cord-014516-r59usk02 2514 48 dogs dog NNS cord-014516-r59usk02 2514 49 ( ( -LRB- cord-014516-r59usk02 2514 50 healthy healthy JJ cord-014516-r59usk02 2514 51 dogs dog NNS cord-014516-r59usk02 2514 52 n n CC cord-014516-r59usk02 2514 53 = = SYM cord-014516-r59usk02 2514 54 21 21 CD cord-014516-r59usk02 2514 55 ; ; : cord-014516-r59usk02 2514 56 dogs dog NNS cord-014516-r59usk02 2514 57 with with IN cord-014516-r59usk02 2514 58 HAC HAC NNP cord-014516-r59usk02 2514 59 n n NN cord-014516-r59usk02 2514 60 = = SYM cord-014516-r59usk02 2514 61 5 5 CD cord-014516-r59usk02 2514 62 ) ) -RRB- cord-014516-r59usk02 2514 63 and and CC cord-014516-r59usk02 2514 64 spayed spay VBN cord-014516-r59usk02 2514 65 females female NNS cord-014516-r59usk02 2514 66 ( ( -LRB- cord-014516-r59usk02 2514 67 healthy healthy JJ cord-014516-r59usk02 2514 68 dogs dog NNS cord-014516-r59usk02 2514 69 n n CC cord-014516-r59usk02 2514 70 = = SYM cord-014516-r59usk02 2514 71 7 7 CD cord-014516-r59usk02 2514 72 ; ; : cord-014516-r59usk02 2514 73 dogs dog NNS cord-014516-r59usk02 2514 74 with with IN cord-014516-r59usk02 2514 75 HAC HAC NNP cord-014516-r59usk02 2514 76 n n NN cord-014516-r59usk02 2514 77 = = SYM cord-014516-r59usk02 2514 78 7 7 CD cord-014516-r59usk02 2514 79 ) ) -RRB- cord-014516-r59usk02 2514 80 . . . cord-014516-r59usk02 2515 1 The the DT cord-014516-r59usk02 2515 2 statistical statistical JJ cord-014516-r59usk02 2515 3 analysis analysis NN cord-014516-r59usk02 2515 4 was be VBD cord-014516-r59usk02 2515 5 performed perform VBN cord-014516-r59usk02 2515 6 with with IN cord-014516-r59usk02 2515 7 Sigma Sigma NNP cord-014516-r59usk02 2515 8 Stat Stat NNP cord-014516-r59usk02 2515 9 . . . cord-014516-r59usk02 2516 1 The the DT cord-014516-r59usk02 2516 2 plasma plasma NN cord-014516-r59usk02 2516 3 cortisol cortisol NN cord-014516-r59usk02 2516 4 - - HYPH cord-014516-r59usk02 2516 5 DHEA dhea NN cord-014516-r59usk02 2516 6 - - HYPH cord-014516-r59usk02 2516 7 ratio ratio NN cord-014516-r59usk02 2516 8 of of IN cord-014516-r59usk02 2516 9 healthy healthy JJ cord-014516-r59usk02 2516 10 male male JJ cord-014516-r59usk02 2516 11 dogs dog NNS cord-014516-r59usk02 2516 12 was be VBD cord-014516-r59usk02 2516 13 the the DT cord-014516-r59usk02 2516 14 lowest low JJS cord-014516-r59usk02 2516 15 ratio ratio NN cord-014516-r59usk02 2516 16 of of IN cord-014516-r59usk02 2516 17 all all DT cord-014516-r59usk02 2516 18 sexual sexual JJ cord-014516-r59usk02 2516 19 categories category NNS cord-014516-r59usk02 2516 20 ( ( -LRB- cord-014516-r59usk02 2516 21 mean mean VB cord-014516-r59usk02 2516 22 average average JJ cord-014516-r59usk02 2516 23 84.8 84.8 CD cord-014516-r59usk02 2516 24 AE AE NNP cord-014516-r59usk02 2516 25 128 128 CD cord-014516-r59usk02 2516 26 ) ) -RRB- cord-014516-r59usk02 2516 27 and and CC cord-014516-r59usk02 2516 28 it -PRON- PRP cord-014516-r59usk02 2516 29 differed differ VBD cord-014516-r59usk02 2516 30 significantly significantly RB cord-014516-r59usk02 2516 31 to to IN cord-014516-r59usk02 2516 32 all all DT cord-014516-r59usk02 2516 33 other other JJ cord-014516-r59usk02 2516 34 sexes sex NNS cord-014516-r59usk02 2516 35 ( ( -LRB- cord-014516-r59usk02 2516 36 neutered neutered JJ cord-014516-r59usk02 2516 37 males male NNS cord-014516-r59usk02 2516 38 = = VBZ cord-014516-r59usk02 2516 39 231 231 CD cord-014516-r59usk02 2516 40 AE AE NNP cord-014516-r59usk02 2516 41 138 138 CD cord-014516-r59usk02 2516 42 , , , cord-014516-r59usk02 2516 43 P p NN cord-014516-r59usk02 2516 44 = = SYM cord-014516-r59usk02 2516 45 0.002 0.002 CD cord-014516-r59usk02 2516 46 ; ; , cord-014516-r59usk02 2516 47 females female NNS cord-014516-r59usk02 2516 48 = = VBZ cord-014516-r59usk02 2516 49 244 244 CD cord-014516-r59usk02 2516 50 AE AE NNP cord-014516-r59usk02 2516 51 124 124 CD cord-014516-r59usk02 2516 52 , , , cord-014516-r59usk02 2516 53 P p NN cord-014516-r59usk02 2516 54 < < XX cord-014516-r59usk02 2516 55 0.001 0.001 CD cord-014516-r59usk02 2516 56 and and CC cord-014516-r59usk02 2516 57 spayed spay VBN cord-014516-r59usk02 2516 58 females female NNS cord-014516-r59usk02 2516 59 ( ( -LRB- cord-014516-r59usk02 2516 60 183 183 CD cord-014516-r59usk02 2516 61 AE AE NNP cord-014516-r59usk02 2516 62 60.0 60.0 CD cord-014516-r59usk02 2516 63 , , , cord-014516-r59usk02 2516 64 P p NN cord-014516-r59usk02 2516 65 = = SYM cord-014516-r59usk02 2516 66 0.006 0.006 CD cord-014516-r59usk02 2516 67 ) ) -RRB- cord-014516-r59usk02 2516 68 . . . cord-014516-r59usk02 2517 1 The the DT cord-014516-r59usk02 2517 2 cortisol cortisol NN cord-014516-r59usk02 2517 3 - - HYPH cord-014516-r59usk02 2517 4 DHEA dhea NN cord-014516-r59usk02 2517 5 - - HYPH cord-014516-r59usk02 2517 6 ratio ratio NN cord-014516-r59usk02 2517 7 showed show VBD cord-014516-r59usk02 2517 8 no no DT cord-014516-r59usk02 2517 9 significant significant JJ cord-014516-r59usk02 2517 10 difference difference NN cord-014516-r59usk02 2517 11 between between IN cord-014516-r59usk02 2517 12 male male JJ cord-014516-r59usk02 2517 13 and and CC cord-014516-r59usk02 2517 14 female female JJ cord-014516-r59usk02 2517 15 dogs dog NNS cord-014516-r59usk02 2517 16 with with IN cord-014516-r59usk02 2517 17 HAC HAC NNP cord-014516-r59usk02 2517 18 . . . cord-014516-r59usk02 2518 1 Spayed spay VBN cord-014516-r59usk02 2518 2 females female NNS cord-014516-r59usk02 2518 3 with with IN cord-014516-r59usk02 2518 4 HAC HAC NNP cord-014516-r59usk02 2518 5 had have VBD cord-014516-r59usk02 2518 6 significantly significantly RB cord-014516-r59usk02 2518 7 higher high JJR cord-014516-r59usk02 2518 8 cortisol cortisol NN cord-014516-r59usk02 2518 9 - - HYPH cord-014516-r59usk02 2518 10 DHEA dhea NN cord-014516-r59usk02 2518 11 - - HYPH cord-014516-r59usk02 2518 12 ratios ratio NNS cord-014516-r59usk02 2518 13 ( ( -LRB- cord-014516-r59usk02 2518 14 501 501 CD cord-014516-r59usk02 2518 15 AE AE NNP cord-014516-r59usk02 2518 16 310 310 CD cord-014516-r59usk02 2518 17 ) ) -RRB- cord-014516-r59usk02 2518 18 than than IN cord-014516-r59usk02 2518 19 healthy healthy JJ cord-014516-r59usk02 2518 20 spayed spayed JJ cord-014516-r59usk02 2518 21 females female NNS cord-014516-r59usk02 2518 22 ( ( -LRB- cord-014516-r59usk02 2518 23 P p NN cord-014516-r59usk02 2518 24 = = SYM cord-014516-r59usk02 2518 25 0.035 0.035 CD cord-014516-r59usk02 2518 26 ) ) -RRB- cord-014516-r59usk02 2518 27 but but CC cord-014516-r59usk02 2518 28 no no DT cord-014516-r59usk02 2518 29 significant significant JJ cord-014516-r59usk02 2518 30 differences difference NNS cord-014516-r59usk02 2518 31 were be VBD cord-014516-r59usk02 2518 32 found find VBN cord-014516-r59usk02 2518 33 in in IN cord-014516-r59usk02 2518 34 other other JJ cord-014516-r59usk02 2518 35 sexual sexual JJ cord-014516-r59usk02 2518 36 categories category NNS cord-014516-r59usk02 2518 37 . . . cord-014516-r59usk02 2519 1 This this DT cord-014516-r59usk02 2519 2 preliminary preliminary JJ cord-014516-r59usk02 2519 3 data data NN cord-014516-r59usk02 2519 4 indicates indicate VBZ cord-014516-r59usk02 2519 5 that that IN cord-014516-r59usk02 2519 6 the the DT cord-014516-r59usk02 2519 7 cortisol cortisol NN cord-014516-r59usk02 2519 8 - - HYPH cord-014516-r59usk02 2519 9 DHEA dhea NN cord-014516-r59usk02 2519 10 - - HYPH cord-014516-r59usk02 2519 11 ratio ratio NN cord-014516-r59usk02 2519 12 might may MD cord-014516-r59usk02 2519 13 not not RB cord-014516-r59usk02 2519 14 be be VB cord-014516-r59usk02 2519 15 a a DT cord-014516-r59usk02 2519 16 very very RB cord-014516-r59usk02 2519 17 promising promising JJ cord-014516-r59usk02 2519 18 tool tool NN cord-014516-r59usk02 2519 19 for for IN cord-014516-r59usk02 2519 20 the the DT cord-014516-r59usk02 2519 21 diagnosis diagnosis NN cord-014516-r59usk02 2519 22 of of IN cord-014516-r59usk02 2519 23 HAC HAC NNP cord-014516-r59usk02 2519 24 . . . cord-014516-r59usk02 2520 1 In in IN cord-014516-r59usk02 2520 2 addition addition NN cord-014516-r59usk02 2520 3 , , , cord-014516-r59usk02 2520 4 the the DT cord-014516-r59usk02 2520 5 significant significant JJ cord-014516-r59usk02 2520 6 gender gender NN cord-014516-r59usk02 2520 7 - - HYPH cord-014516-r59usk02 2520 8 dependency dependency NN cord-014516-r59usk02 2520 9 of of IN cord-014516-r59usk02 2520 10 this this DT cord-014516-r59usk02 2520 11 parameter parameter NN cord-014516-r59usk02 2520 12 has have VBZ cord-014516-r59usk02 2520 13 to to TO cord-014516-r59usk02 2520 14 be be VB cord-014516-r59usk02 2520 15 considered consider VBN cord-014516-r59usk02 2520 16 and and CC cord-014516-r59usk02 2520 17 may may MD cord-014516-r59usk02 2520 18 generally generally RB cord-014516-r59usk02 2520 19 limit limit VB cord-014516-r59usk02 2520 20 its -PRON- PRP$ cord-014516-r59usk02 2520 21 clinical clinical JJ cord-014516-r59usk02 2520 22 usefulness usefulness NN cord-014516-r59usk02 2520 23 . . . cord-014516-r59usk02 2521 1 This this DT cord-014516-r59usk02 2521 2 study study NN cord-014516-r59usk02 2521 3 is be VBZ cord-014516-r59usk02 2521 4 financially financially RB cord-014516-r59usk02 2521 5 supported support VBN cord-014516-r59usk02 2521 6 by by IN cord-014516-r59usk02 2521 7 the the DT cord-014516-r59usk02 2521 8 Bruns Bruns NNP cord-014516-r59usk02 2521 9 - - HYPH cord-014516-r59usk02 2521 10 Stiftung Stiftung NNP cord-014516-r59usk02 2521 11 . . . cord-014516-r59usk02 2522 1 No no DT cord-014516-r59usk02 2522 2 conflicts conflict NNS cord-014516-r59usk02 2522 3 of of IN cord-014516-r59usk02 2522 4 interest interest NN cord-014516-r59usk02 2522 5 reported report VBN cord-014516-r59usk02 2522 6 . . . cord-014516-r59usk02 2523 1 Hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2523 2 is be VBZ cord-014516-r59usk02 2523 3 common common JJ cord-014516-r59usk02 2523 4 in in IN cord-014516-r59usk02 2523 5 older old JJR cord-014516-r59usk02 2523 6 cats cat NNS cord-014516-r59usk02 2523 7 . . . cord-014516-r59usk02 2524 1 The the DT cord-014516-r59usk02 2524 2 aim aim NN cord-014516-r59usk02 2524 3 of of IN cord-014516-r59usk02 2524 4 this this DT cord-014516-r59usk02 2524 5 study study NN cord-014516-r59usk02 2524 6 was be VBD cord-014516-r59usk02 2524 7 to to TO cord-014516-r59usk02 2524 8 assess assess VB cord-014516-r59usk02 2524 9 the the DT cord-014516-r59usk02 2524 10 prevalence prevalence NN cord-014516-r59usk02 2524 11 of of IN cord-014516-r59usk02 2524 12 feline feline JJ cord-014516-r59usk02 2524 13 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2524 14 and and CC cord-014516-r59usk02 2524 15 potential potential JJ cord-014516-r59usk02 2524 16 intrinsic intrinsic JJ cord-014516-r59usk02 2524 17 risk risk NN cord-014516-r59usk02 2524 18 factors factor NNS cord-014516-r59usk02 2524 19 in in IN cord-014516-r59usk02 2524 20 a a DT cord-014516-r59usk02 2524 21 hospital hospital NN cord-014516-r59usk02 2524 22 population population NN cord-014516-r59usk02 2524 23 in in IN cord-014516-r59usk02 2524 24 Southern Southern NNP cord-014516-r59usk02 2524 25 Germany Germany NNP cord-014516-r59usk02 2524 26 . . . cord-014516-r59usk02 2525 1 Total total JJ cord-014516-r59usk02 2525 2 thyroxine thyroxine NN cord-014516-r59usk02 2525 3 ( ( -LRB- cord-014516-r59usk02 2525 4 T4 T4 NNP cord-014516-r59usk02 2525 5 ) ) -RRB- cord-014516-r59usk02 2525 6 was be VBD cord-014516-r59usk02 2525 7 prospectively prospectively RB cord-014516-r59usk02 2525 8 measured measure VBN cord-014516-r59usk02 2525 9 by by IN cord-014516-r59usk02 2525 10 enzyme enzyme NN cord-014516-r59usk02 2525 11 immunoassay immunoassay NN cord-014516-r59usk02 2525 12 ( ( -LRB- cord-014516-r59usk02 2525 13 EIA EIA NNP cord-014516-r59usk02 2525 14 ) ) -RRB- cord-014516-r59usk02 2525 15 in in IN cord-014516-r59usk02 2525 16 sera sera NNP cord-014516-r59usk02 2525 17 of of IN cord-014516-r59usk02 2525 18 425 425 CD cord-014516-r59usk02 2525 19 cats cat NNS cord-014516-r59usk02 2525 20 older old JJR cord-014516-r59usk02 2525 21 than than IN cord-014516-r59usk02 2525 22 8 8 CD cord-014516-r59usk02 2525 23 years year NNS cord-014516-r59usk02 2525 24 that that WDT cord-014516-r59usk02 2525 25 were be VBD cord-014516-r59usk02 2525 26 presented present VBN cord-014516-r59usk02 2525 27 to to IN cord-014516-r59usk02 2525 28 the the DT cord-014516-r59usk02 2525 29 Clinic Clinic NNP cord-014516-r59usk02 2525 30 of of IN cord-014516-r59usk02 2525 31 Small Small NNP cord-014516-r59usk02 2525 32 Animal Animal NNP cord-014516-r59usk02 2525 33 Medicine Medicine NNP cord-014516-r59usk02 2525 34 . . . cord-014516-r59usk02 2526 1 A a DT cord-014516-r59usk02 2526 2 standardized standardized JJ cord-014516-r59usk02 2526 3 physical physical JJ cord-014516-r59usk02 2526 4 examination examination NN cord-014516-r59usk02 2526 5 was be VBD cord-014516-r59usk02 2526 6 performed perform VBN cord-014516-r59usk02 2526 7 , , , cord-014516-r59usk02 2526 8 and and CC cord-014516-r59usk02 2526 9 body body NN cord-014516-r59usk02 2526 10 condition condition NN cord-014516-r59usk02 2526 11 score score NN cord-014516-r59usk02 2526 12 ( ( -LRB- cord-014516-r59usk02 2526 13 BCS BCS NNP cord-014516-r59usk02 2526 14 ) ) -RRB- cord-014516-r59usk02 2526 15 and and CC cord-014516-r59usk02 2526 16 thyroid thyroid JJ cord-014516-r59usk02 2526 17 palpation palpation NN cord-014516-r59usk02 2526 18 score score NN cord-014516-r59usk02 2526 19 ( ( -LRB- cord-014516-r59usk02 2526 20 TPS TPS NNP cord-014516-r59usk02 2526 21 ) ) -RRB- cord-014516-r59usk02 2526 22 were be VBD cord-014516-r59usk02 2526 23 assessed assess VBN cord-014516-r59usk02 2526 24 . . . cord-014516-r59usk02 2527 1 Association Association NNP cord-014516-r59usk02 2527 2 between between IN cord-014516-r59usk02 2527 3 signalement signalement NNP cord-014516-r59usk02 2527 4 , , , cord-014516-r59usk02 2527 5 BCS BCS NNP cord-014516-r59usk02 2527 6 and and CC cord-014516-r59usk02 2527 7 TPS TPS NNP cord-014516-r59usk02 2527 8 was be VBD cord-014516-r59usk02 2527 9 analyzed analyze VBN cord-014516-r59usk02 2527 10 by by IN cord-014516-r59usk02 2527 11 Student student NN cord-014516-r59usk02 2527 12 0 0 CD cord-014516-r59usk02 2527 13 s s NN cord-014516-r59usk02 2527 14 unpaired unpaired JJ cord-014516-r59usk02 2527 15 t t NN cord-014516-r59usk02 2527 16 - - HYPH cord-014516-r59usk02 2527 17 test test NN cord-014516-r59usk02 2527 18 , , , cord-014516-r59usk02 2527 19 Chi Chi NNP cord-014516-r59usk02 2527 20 - - HYPH cord-014516-r59usk02 2527 21 Square Square NNP cord-014516-r59usk02 2527 22 , , , cord-014516-r59usk02 2527 23 and and CC cord-014516-r59usk02 2527 24 Mann Mann NNP cord-014516-r59usk02 2527 25 - - HYPH cord-014516-r59usk02 2527 26 Whitney Whitney NNP cord-014516-r59usk02 2527 27 test test NN cord-014516-r59usk02 2527 28 . . . cord-014516-r59usk02 2528 1 Level level NN cord-014516-r59usk02 2528 2 of of IN cord-014516-r59usk02 2528 3 significance significance NN cord-014516-r59usk02 2528 4 was be VBD cord-014516-r59usk02 2528 5 set set VBN cord-014516-r59usk02 2528 6 at at IN cord-014516-r59usk02 2528 7 0.05 0.05 CD cord-014516-r59usk02 2528 8 . . . cord-014516-r59usk02 2529 1 Fifty fifty CD cord-014516-r59usk02 2529 2 nine nine CD cord-014516-r59usk02 2529 3 cats cat NNS cord-014516-r59usk02 2529 4 were be VBD cord-014516-r59usk02 2529 5 diagnosed diagnose VBN cord-014516-r59usk02 2529 6 with with IN cord-014516-r59usk02 2529 7 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2529 8 leading lead VBG cord-014516-r59usk02 2529 9 to to IN cord-014516-r59usk02 2529 10 a a DT cord-014516-r59usk02 2529 11 prevalence prevalence NN cord-014516-r59usk02 2529 12 of of IN cord-014516-r59usk02 2529 13 13.9 13.9 CD cord-014516-r59usk02 2529 14 % % NN cord-014516-r59usk02 2529 15 ( ( -LRB- cord-014516-r59usk02 2529 16 CI CI NNP cord-014516-r59usk02 2529 17 10.9 10.9 CD cord-014516-r59usk02 2529 18 - - HYPH cord-014516-r59usk02 2529 19 17.5 17.5 CD cord-014516-r59usk02 2529 20 ) ) -RRB- cord-014516-r59usk02 2529 21 . . . cord-014516-r59usk02 2530 1 Hyperthyroid Hyperthyroid NNP cord-014516-r59usk02 2530 2 cats cat NNS cord-014516-r59usk02 2530 3 were be VBD cord-014516-r59usk02 2530 4 older old JJR cord-014516-r59usk02 2530 5 than than IN cord-014516-r59usk02 2530 6 non non JJ cord-014516-r59usk02 2530 7 - - JJ cord-014516-r59usk02 2530 8 hyperthyroid hyperthyroid JJ cord-014516-r59usk02 2530 9 cats cat NNS cord-014516-r59usk02 2530 10 ( ( -LRB- cord-014516-r59usk02 2530 11 p p NN cord-014516-r59usk02 2530 12 < < XX cord-014516-r59usk02 2530 13 0.0001 0.0001 CD cord-014516-r59usk02 2530 14 ) ) -RRB- cord-014516-r59usk02 2530 15 and and CC cord-014516-r59usk02 2530 16 more more RBR cord-014516-r59usk02 2530 17 often often RB cord-014516-r59usk02 2530 18 female female JJ cord-014516-r59usk02 2530 19 ( ( -LRB- cord-014516-r59usk02 2530 20 p p NN cord-014516-r59usk02 2530 21 = = SYM cord-014516-r59usk02 2530 22 0.024 0.024 CD cord-014516-r59usk02 2530 23 , , , cord-014516-r59usk02 2530 24 odds odd NNS cord-014516-r59usk02 2530 25 ratio ratio NN cord-014516-r59usk02 2530 26 1.920 1.920 CD cord-014516-r59usk02 2530 27 ) ) -RRB- cord-014516-r59usk02 2530 28 . . . cord-014516-r59usk02 2531 1 Domestic domestic JJ cord-014516-r59usk02 2531 2 short short JJ cord-014516-r59usk02 2531 3 or or CC cord-014516-r59usk02 2531 4 long long JJ cord-014516-r59usk02 2531 5 hair hair NN cord-014516-r59usk02 2531 6 cats cat NNS cord-014516-r59usk02 2531 7 were be VBD cord-014516-r59usk02 2531 8 more more RBR cord-014516-r59usk02 2531 9 often often RB cord-014516-r59usk02 2531 10 affected affect VBN cord-014516-r59usk02 2531 11 than than IN cord-014516-r59usk02 2531 12 pedigrees pedigree NNS cord-014516-r59usk02 2531 13 ( ( -LRB- cord-014516-r59usk02 2531 14 p p NN cord-014516-r59usk02 2531 15 = = SYM cord-014516-r59usk02 2531 16 0.015 0.015 CD cord-014516-r59usk02 2531 17 ) ) -RRB- cord-014516-r59usk02 2531 18 . . . cord-014516-r59usk02 2532 1 Hyperthyroid Hyperthyroid NNP cord-014516-r59usk02 2532 2 cats cat NNS cord-014516-r59usk02 2532 3 had have VBD cord-014516-r59usk02 2532 4 higher high JJR cord-014516-r59usk02 2532 5 TPS TPS NNP cord-014516-r59usk02 2532 6 ( ( -LRB- cord-014516-r59usk02 2532 7 p p NN cord-014516-r59usk02 2532 8 < < XX cord-014516-r59usk02 2532 9 0.0001 0.0001 CD cord-014516-r59usk02 2532 10 ) ) -RRB- cord-014516-r59usk02 2532 11 and and CC cord-014516-r59usk02 2532 12 lower low JJR cord-014516-r59usk02 2532 13 weight weight NN cord-014516-r59usk02 2532 14 than than IN cord-014516-r59usk02 2532 15 non non JJ cord-014516-r59usk02 2532 16 - - JJ cord-014516-r59usk02 2532 17 hyperthyroid hyperthyroid JJ cord-014516-r59usk02 2532 18 cats cat NNS cord-014516-r59usk02 2532 19 ( ( -LRB- cord-014516-r59usk02 2532 20 p p NN cord-014516-r59usk02 2532 21 < < XX cord-014516-r59usk02 2532 22 0.0001 0.0001 CD cord-014516-r59usk02 2532 23 ) ) -RRB- cord-014516-r59usk02 2532 24 although although IN cord-014516-r59usk02 2532 25 BCS BCS NNP cord-014516-r59usk02 2532 26 was be VBD cord-014516-r59usk02 2532 27 not not RB cord-014516-r59usk02 2532 28 different different JJ cord-014516-r59usk02 2532 29 ( ( -LRB- cord-014516-r59usk02 2532 30 p p NN cord-014516-r59usk02 2532 31 = = SYM cord-014516-r59usk02 2532 32 0.290 0.290 CD cord-014516-r59usk02 2532 33 ) ) -RRB- cord-014516-r59usk02 2532 34 . . . cord-014516-r59usk02 2533 1 In in IN cord-014516-r59usk02 2533 2 11 11 CD cord-014516-r59usk02 2533 3 ( ( -LRB- cord-014516-r59usk02 2533 4 2.5 2.5 CD cord-014516-r59usk02 2533 5 % % NN cord-014516-r59usk02 2533 6 ) ) -RRB- cord-014516-r59usk02 2533 7 cats cat NNS cord-014516-r59usk02 2533 8 , , , cord-014516-r59usk02 2533 9 the the DT cord-014516-r59usk02 2533 10 elevated elevated JJ cord-014516-r59usk02 2533 11 T4 T4 NNP cord-014516-r59usk02 2533 12 was be VBD cord-014516-r59usk02 2533 13 an an DT cord-014516-r59usk02 2533 14 incidental incidental JJ cord-014516-r59usk02 2533 15 finding finding NN cord-014516-r59usk02 2533 16 . . . cord-014516-r59usk02 2534 1 In in IN cord-014516-r59usk02 2534 2 3 3 CD cord-014516-r59usk02 2534 3 of of IN cord-014516-r59usk02 2534 4 those those DT cord-014516-r59usk02 2534 5 , , , cord-014516-r59usk02 2534 6 the the DT cord-014516-r59usk02 2534 7 disease disease NN cord-014516-r59usk02 2534 8 was be VBD cord-014516-r59usk02 2534 9 confirmed confirm VBN cord-014516-r59usk02 2534 10 later later RB cord-014516-r59usk02 2534 11 ( ( -LRB- cord-014516-r59usk02 2534 12 the the DT cord-014516-r59usk02 2534 13 others other NNS cord-014516-r59usk02 2534 14 were be VBD cord-014516-r59usk02 2534 15 dead dead JJ cord-014516-r59usk02 2534 16 due due IN cord-014516-r59usk02 2534 17 to to IN cord-014516-r59usk02 2534 18 unrelated unrelated JJ cord-014516-r59usk02 2534 19 diseases disease NNS cord-014516-r59usk02 2534 20 ) ) -RRB- cord-014516-r59usk02 2534 21 . . . cord-014516-r59usk02 2535 1 In in IN cord-014516-r59usk02 2535 2 152 152 CD cord-014516-r59usk02 2535 3 patients patient NNS cord-014516-r59usk02 2535 4 , , , cord-014516-r59usk02 2535 5 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2535 6 was be VBD cord-014516-r59usk02 2535 7 considered consider VBN cord-014516-r59usk02 2535 8 a a DT cord-014516-r59usk02 2535 9 differential differential JJ cord-014516-r59usk02 2535 10 diagnosis diagnosis NN cord-014516-r59usk02 2535 11 and and CC cord-014516-r59usk02 2535 12 was be VBD cord-014516-r59usk02 2535 13 confirmed confirm VBN cord-014516-r59usk02 2535 14 in in IN cord-014516-r59usk02 2535 15 32 32 CD cord-014516-r59usk02 2535 16 ( ( -LRB- cord-014516-r59usk02 2535 17 21.1 21.1 CD cord-014516-r59usk02 2535 18 % % NN cord-014516-r59usk02 2535 19 ) ) -RRB- cord-014516-r59usk02 2535 20 cats cat NNS cord-014516-r59usk02 2535 21 although although IN cord-014516-r59usk02 2535 22 in in IN cord-014516-r59usk02 2535 23 5 5 CD cord-014516-r59usk02 2535 24 cats cat NNS cord-014516-r59usk02 2535 25 additional additional JJ cord-014516-r59usk02 2535 26 diagnostic diagnostic JJ cord-014516-r59usk02 2535 27 means mean NNS cord-014516-r59usk02 2535 28 were be VBD cord-014516-r59usk02 2535 29 necessary necessary JJ cord-014516-r59usk02 2535 30 . . . cord-014516-r59usk02 2536 1 Older old JJR cord-014516-r59usk02 2536 2 female female JJ cord-014516-r59usk02 2536 3 domestic domestic JJ cord-014516-r59usk02 2536 4 cats cat NNS cord-014516-r59usk02 2536 5 are be VBP cord-014516-r59usk02 2536 6 predisposed predisposed JJ cord-014516-r59usk02 2536 7 to to IN cord-014516-r59usk02 2536 8 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2536 9 which which WDT cord-014516-r59usk02 2536 10 is be VBZ cord-014516-r59usk02 2536 11 frequently frequently RB cord-014516-r59usk02 2536 12 diagnosed diagnose VBN cord-014516-r59usk02 2536 13 after after IN cord-014516-r59usk02 2536 14 the the DT cord-014516-r59usk02 2536 15 initial initial JJ cord-014516-r59usk02 2536 16 clinical clinical JJ cord-014516-r59usk02 2536 17 suspect suspect NN cord-014516-r59usk02 2536 18 . . . cord-014516-r59usk02 2537 1 In in IN cord-014516-r59usk02 2537 2 a a DT cord-014516-r59usk02 2537 3 few few JJ cord-014516-r59usk02 2537 4 affected affected JJ cord-014516-r59usk02 2537 5 cats cat NNS cord-014516-r59usk02 2537 6 an an DT cord-014516-r59usk02 2537 7 elevated elevated JJ cord-014516-r59usk02 2537 8 T4 t4 NN cord-014516-r59usk02 2537 9 is be VBZ cord-014516-r59usk02 2537 10 not not RB cord-014516-r59usk02 2537 11 present present JJ cord-014516-r59usk02 2537 12 or or CC cord-014516-r59usk02 2537 13 can can MD cord-014516-r59usk02 2537 14 precede precede VB cord-014516-r59usk02 2537 15 clinical clinical JJ cord-014516-r59usk02 2537 16 signs sign NNS cord-014516-r59usk02 2537 17 . . . cord-014516-r59usk02 2538 1 Conflicts conflict NNS cord-014516-r59usk02 2538 2 of of IN cord-014516-r59usk02 2538 3 interest interest NN cord-014516-r59usk02 2538 4 : : : cord-014516-r59usk02 2538 5 The the DT cord-014516-r59usk02 2538 6 study study NN cord-014516-r59usk02 2538 7 was be VBD cord-014516-r59usk02 2538 8 partially partially RB cord-014516-r59usk02 2538 9 funded fund VBN cord-014516-r59usk02 2538 10 by by IN cord-014516-r59usk02 2538 11 MSD MSD NNP cord-014516-r59usk02 2538 12 Intervet Intervet NNP cord-014516-r59usk02 2538 13 . . . cord-014516-r59usk02 2539 1 The the DT cord-014516-r59usk02 2539 2 main main JJ cord-014516-r59usk02 2539 3 endocrinopathy endocrinopathy NN cord-014516-r59usk02 2539 4 affecting affect VBG cord-014516-r59usk02 2539 5 both both DT cord-014516-r59usk02 2539 6 humans human NNS cord-014516-r59usk02 2539 7 and and CC cord-014516-r59usk02 2539 8 pet pet JJ cord-014516-r59usk02 2539 9 felines feline NNS cord-014516-r59usk02 2539 10 is be VBZ cord-014516-r59usk02 2539 11 diabetes diabetes NN cord-014516-r59usk02 2539 12 mellitus mellitus NN cord-014516-r59usk02 2539 13 . . . cord-014516-r59usk02 2540 1 Accurate accurate JJ cord-014516-r59usk02 2540 2 diagnosis diagnosis NN cord-014516-r59usk02 2540 3 is be VBZ cord-014516-r59usk02 2540 4 the the DT cord-014516-r59usk02 2540 5 most most RBS cord-014516-r59usk02 2540 6 important important JJ cord-014516-r59usk02 2540 7 aspect aspect NN cord-014516-r59usk02 2540 8 in in IN cord-014516-r59usk02 2540 9 the the DT cord-014516-r59usk02 2540 10 future future JJ cord-014516-r59usk02 2540 11 outcome outcome NN cord-014516-r59usk02 2540 12 of of IN cord-014516-r59usk02 2540 13 the the DT cord-014516-r59usk02 2540 14 disease disease NN cord-014516-r59usk02 2540 15 . . . cord-014516-r59usk02 2541 1 A a DT cord-014516-r59usk02 2541 2 computer computer NN cord-014516-r59usk02 2541 3 based base VBN cord-014516-r59usk02 2541 4 Decision Decision NNP cord-014516-r59usk02 2541 5 Support Support NNP cord-014516-r59usk02 2541 6 System System NNP cord-014516-r59usk02 2541 7 ( ( -LRB- cord-014516-r59usk02 2541 8 DSS DSS NNP cord-014516-r59usk02 2541 9 ) ) -RRB- cord-014516-r59usk02 2541 10 is be VBZ cord-014516-r59usk02 2541 11 targeted target VBN cord-014516-r59usk02 2541 12 on on IN cord-014516-r59usk02 2541 13 assisting assist VBG cord-014516-r59usk02 2541 14 clinicians clinician NNS cord-014516-r59usk02 2541 15 with with IN cord-014516-r59usk02 2541 16 one one CD cord-014516-r59usk02 2541 17 or or CC cord-014516-r59usk02 2541 18 more more JJR cord-014516-r59usk02 2541 19 steps step NNS cord-014516-r59usk02 2541 20 of of IN cord-014516-r59usk02 2541 21 the the DT cord-014516-r59usk02 2541 22 diagnostic diagnostic JJ cord-014516-r59usk02 2541 23 process process NN cord-014516-r59usk02 2541 24 . . . cord-014516-r59usk02 2542 1 The the DT cord-014516-r59usk02 2542 2 novelty novelty NN cord-014516-r59usk02 2542 3 of of IN cord-014516-r59usk02 2542 4 our -PRON- PRP$ cord-014516-r59usk02 2542 5 DSS DSS NNP cord-014516-r59usk02 2542 6 emerges emerge VBZ cord-014516-r59usk02 2542 7 from from IN cord-014516-r59usk02 2542 8 the the DT cord-014516-r59usk02 2542 9 possibility possibility NN cord-014516-r59usk02 2542 10 of of IN cord-014516-r59usk02 2542 11 assisting assist VBG cord-014516-r59usk02 2542 12 both both CC cord-014516-r59usk02 2542 13 clinical clinical JJ cord-014516-r59usk02 2542 14 and and CC cord-014516-r59usk02 2542 15 paraclinical paraclinical JJ cord-014516-r59usk02 2542 16 diagnosis diagnosis NN cord-014516-r59usk02 2542 17 stages stage NNS cord-014516-r59usk02 2542 18 of of IN cord-014516-r59usk02 2542 19 diabetes diabetes NN cord-014516-r59usk02 2542 20 mellitus mellitus NN cord-014516-r59usk02 2542 21 and and CC cord-014516-r59usk02 2542 22 all all DT cord-014516-r59usk02 2542 23 common common JJ cord-014516-r59usk02 2542 24 combination combination NN cord-014516-r59usk02 2542 25 of of IN cord-014516-r59usk02 2542 26 disorders disorder NNS cord-014516-r59usk02 2542 27 associated associate VBN cord-014516-r59usk02 2542 28 with with IN cord-014516-r59usk02 2542 29 this this DT cord-014516-r59usk02 2542 30 endocrinopathy endocrinopathy NN cord-014516-r59usk02 2542 31 . . . cord-014516-r59usk02 2543 1 The the DT cord-014516-r59usk02 2543 2 motivation motivation NN cord-014516-r59usk02 2543 3 behind behind IN cord-014516-r59usk02 2543 4 the the DT cord-014516-r59usk02 2543 5 development development NN cord-014516-r59usk02 2543 6 of of IN cord-014516-r59usk02 2543 7 such such JJ cord-014516-r59usk02 2543 8 system system NN cord-014516-r59usk02 2543 9 is be VBZ cord-014516-r59usk02 2543 10 the the DT cord-014516-r59usk02 2543 11 desire desire NN cord-014516-r59usk02 2543 12 to to TO cord-014516-r59usk02 2543 13 maximize maximize VB cord-014516-r59usk02 2543 14 the the DT cord-014516-r59usk02 2543 15 reliability reliability NN cord-014516-r59usk02 2543 16 of of IN cord-014516-r59usk02 2543 17 clinical clinical JJ cord-014516-r59usk02 2543 18 decisions decision NNS cord-014516-r59usk02 2543 19 . . . cord-014516-r59usk02 2544 1 The the DT cord-014516-r59usk02 2544 2 design design NN cord-014516-r59usk02 2544 3 of of IN cord-014516-r59usk02 2544 4 our -PRON- PRP$ cord-014516-r59usk02 2544 5 feline feline JJ cord-014516-r59usk02 2544 6 diabetes diabetes NN cord-014516-r59usk02 2544 7 mellitus mellitus NN cord-014516-r59usk02 2544 8 DSS DSS NNP cord-014516-r59usk02 2544 9 emerges emerge VBZ cord-014516-r59usk02 2544 10 from from IN cord-014516-r59usk02 2544 11 the the DT cord-014516-r59usk02 2544 12 syndrome syndrome NN cord-014516-r59usk02 2544 13 of of IN cord-014516-r59usk02 2544 14 polyuria polyuria NN cord-014516-r59usk02 2544 15 - - HYPH cord-014516-r59usk02 2544 16 polydipsia polydipsia NN cord-014516-r59usk02 2544 17 , , , cord-014516-r59usk02 2544 18 with with IN cord-014516-r59usk02 2544 19 the the DT cord-014516-r59usk02 2544 20 possibility possibility NN cord-014516-r59usk02 2544 21 of of IN cord-014516-r59usk02 2544 22 spotting spot VBG cord-014516-r59usk02 2544 23 the the DT cord-014516-r59usk02 2544 24 accompanying accompany VBG cord-014516-r59usk02 2544 25 pathologies pathology NNS cord-014516-r59usk02 2544 26 . . . cord-014516-r59usk02 2545 1 Fuzzy fuzzy JJ cord-014516-r59usk02 2545 2 logic logic NN cord-014516-r59usk02 2545 3 is be VBZ cord-014516-r59usk02 2545 4 used use VBN cord-014516-r59usk02 2545 5 for for IN cord-014516-r59usk02 2545 6 dealing deal VBG cord-014516-r59usk02 2545 7 with with IN cord-014516-r59usk02 2545 8 knowledge knowledge NN cord-014516-r59usk02 2545 9 representation representation NN cord-014516-r59usk02 2545 10 and and CC cord-014516-r59usk02 2545 11 uncertainty uncertainty NN cord-014516-r59usk02 2545 12 . . . cord-014516-r59usk02 2546 1 The the DT cord-014516-r59usk02 2546 2 fuzzy fuzzy JJ cord-014516-r59usk02 2546 3 rules rule NNS cord-014516-r59usk02 2546 4 proposed propose VBN cord-014516-r59usk02 2546 5 to to TO cord-014516-r59usk02 2546 6 represent represent VB cord-014516-r59usk02 2546 7 this this DT cord-014516-r59usk02 2546 8 knowledge knowledge NN cord-014516-r59usk02 2546 9 emerge emerge VB cord-014516-r59usk02 2546 10 from from IN cord-014516-r59usk02 2546 11 anamnesis anamnesis NN cord-014516-r59usk02 2546 12 , , , cord-014516-r59usk02 2546 13 clinician clinician NN cord-014516-r59usk02 2546 14 's 's POS cord-014516-r59usk02 2546 15 input input NN cord-014516-r59usk02 2546 16 , , , cord-014516-r59usk02 2546 17 clinical clinical JJ cord-014516-r59usk02 2546 18 and and CC cord-014516-r59usk02 2546 19 paraclinical paraclinical JJ cord-014516-r59usk02 2546 20 description description NN cord-014516-r59usk02 2546 21 , , , cord-014516-r59usk02 2546 22 and and CC cord-014516-r59usk02 2546 23 confirmation confirmation NN cord-014516-r59usk02 2546 24 diagnostic diagnostic JJ cord-014516-r59usk02 2546 25 tests test NNS cord-014516-r59usk02 2546 26 . . . cord-014516-r59usk02 2547 1 Clinical clinical JJ cord-014516-r59usk02 2547 2 signs sign NNS cord-014516-r59usk02 2547 3 such such JJ cord-014516-r59usk02 2547 4 as as IN cord-014516-r59usk02 2547 5 polyuriapolydipsia polyuriapolydipsia NNP cord-014516-r59usk02 2547 6 , , , cord-014516-r59usk02 2547 7 persistent persistent JJ cord-014516-r59usk02 2547 8 hyperglycemia hyperglycemia NN cord-014516-r59usk02 2547 9 , , , cord-014516-r59usk02 2547 10 polyphagia polyphagia NNP cord-014516-r59usk02 2547 11 , , , cord-014516-r59usk02 2547 12 weight weight NN cord-014516-r59usk02 2547 13 fluctuations fluctuation NNS cord-014516-r59usk02 2547 14 , , , cord-014516-r59usk02 2547 15 administration administration NN cord-014516-r59usk02 2547 16 of of IN cord-014516-r59usk02 2547 17 drugs drug NNS cord-014516-r59usk02 2547 18 with with IN cord-014516-r59usk02 2547 19 a a DT cord-014516-r59usk02 2547 20 diabetogenic diabetogenic NNP cord-014516-r59usk02 2547 21 potential potential NN cord-014516-r59usk02 2547 22 , , , cord-014516-r59usk02 2547 23 were be VBD cord-014516-r59usk02 2547 24 considered consider VBN cord-014516-r59usk02 2547 25 decisive decisive JJ cord-014516-r59usk02 2547 26 in in IN cord-014516-r59usk02 2547 27 the the DT cord-014516-r59usk02 2547 28 pattern pattern NN cord-014516-r59usk02 2547 29 of of IN cord-014516-r59usk02 2547 30 diagnosis diagnosis NN cord-014516-r59usk02 2547 31 establishment establishment NN cord-014516-r59usk02 2547 32 . . . cord-014516-r59usk02 2548 1 Registered register VBN cord-014516-r59usk02 2548 2 medical medical JJ cord-014516-r59usk02 2548 3 records record NNS cord-014516-r59usk02 2548 4 of of IN cord-014516-r59usk02 2548 5 29 29 CD cord-014516-r59usk02 2548 6 cats cat NNS cord-014516-r59usk02 2548 7 , , , cord-014516-r59usk02 2548 8 16 16 CD cord-014516-r59usk02 2548 9 males male NNS cord-014516-r59usk02 2548 10 and and CC cord-014516-r59usk02 2548 11 13 13 CD cord-014516-r59usk02 2548 12 females female NNS cord-014516-r59usk02 2548 13 , , , cord-014516-r59usk02 2548 14 whit whit NNP cord-014516-r59usk02 2548 15 ages age NNS cord-014516-r59usk02 2548 16 from from IN cord-014516-r59usk02 2548 17 7 7 CD cord-014516-r59usk02 2548 18 to to TO cord-014516-r59usk02 2548 19 18 18 CD cord-014516-r59usk02 2548 20 years year NNS cord-014516-r59usk02 2548 21 old old JJ cord-014516-r59usk02 2548 22 , , , cord-014516-r59usk02 2548 23 were be VBD cord-014516-r59usk02 2548 24 analyzed analyze VBN cord-014516-r59usk02 2548 25 in in IN cord-014516-r59usk02 2548 26 order order NN cord-014516-r59usk02 2548 27 to to TO cord-014516-r59usk02 2548 28 validate validate VB cord-014516-r59usk02 2548 29 the the DT cord-014516-r59usk02 2548 30 DSS DSS NNP cord-014516-r59usk02 2548 31 . . . cord-014516-r59usk02 2549 1 Using use VBG cord-014516-r59usk02 2549 2 Matlab Matlab NNP cord-014516-r59usk02 2549 3 software software NN cord-014516-r59usk02 2549 4 , , , cord-014516-r59usk02 2549 5 the the DT cord-014516-r59usk02 2549 6 DSS DSS NNP cord-014516-r59usk02 2549 7 was be VBD cord-014516-r59usk02 2549 8 implemented implement VBN cord-014516-r59usk02 2549 9 and and CC cord-014516-r59usk02 2549 10 tested test VBN cord-014516-r59usk02 2549 11 . . . cord-014516-r59usk02 2550 1 For for IN cord-014516-r59usk02 2550 2 any any DT cord-014516-r59usk02 2550 3 case case NN cord-014516-r59usk02 2550 4 with with IN cord-014516-r59usk02 2550 5 polyuria polyuria NN cord-014516-r59usk02 2550 6 - - HYPH cord-014516-r59usk02 2550 7 polydipsia polydipsia NN cord-014516-r59usk02 2550 8 the the DT cord-014516-r59usk02 2550 9 system system NN cord-014516-r59usk02 2550 10 provides provide VBZ cord-014516-r59usk02 2550 11 , , , cord-014516-r59usk02 2550 12 via via IN cord-014516-r59usk02 2550 13 a a DT cord-014516-r59usk02 2550 14 friendly friendly JJ cord-014516-r59usk02 2550 15 graphical graphical JJ cord-014516-r59usk02 2550 16 user user NN cord-014516-r59usk02 2550 17 interface interface NN cord-014516-r59usk02 2550 18 , , , cord-014516-r59usk02 2550 19 the the DT cord-014516-r59usk02 2550 20 diagnosis diagnosis NN cord-014516-r59usk02 2550 21 with with IN cord-014516-r59usk02 2550 22 the the DT cord-014516-r59usk02 2550 23 highest high JJS cord-014516-r59usk02 2550 24 probability probability NN cord-014516-r59usk02 2550 25 . . . cord-014516-r59usk02 2551 1 The the DT cord-014516-r59usk02 2551 2 set set NN cord-014516-r59usk02 2551 3 of of IN cord-014516-r59usk02 2551 4 diagnoses diagnosis NNS cord-014516-r59usk02 2551 5 which which WDT cord-014516-r59usk02 2551 6 can can MD cord-014516-r59usk02 2551 7 be be VB cord-014516-r59usk02 2551 8 generated generate VBN cord-014516-r59usk02 2551 9 by by IN cord-014516-r59usk02 2551 10 the the DT cord-014516-r59usk02 2551 11 DSS DSS NNP cord-014516-r59usk02 2551 12 consists consist VBZ cord-014516-r59usk02 2551 13 in in IN cord-014516-r59usk02 2551 14 : : : cord-014516-r59usk02 2551 15 a a LS cord-014516-r59usk02 2551 16 ) ) -RRB- cord-014516-r59usk02 2551 17 diabetes diabetes NN cord-014516-r59usk02 2551 18 mellitus mellitus NN cord-014516-r59usk02 2551 19 ; ; : cord-014516-r59usk02 2551 20 b b LS cord-014516-r59usk02 2551 21 ) ) -RRB- cord-014516-r59usk02 2551 22 diabetes diabete VBZ cord-014516-r59usk02 2551 23 mellitus mellitus NN cord-014516-r59usk02 2551 24 induced induce VBN cord-014516-r59usk02 2551 25 by by IN cord-014516-r59usk02 2551 26 ( ( -LRB- cord-014516-r59usk02 2551 27 b.1 b.1 NNP cord-014516-r59usk02 2551 28 ) ) -RRB- cord-014516-r59usk02 2551 29 hypersomathotropism hypersomathotropism NNP cord-014516-r59usk02 2551 30 , , , cord-014516-r59usk02 2551 31 ( ( -LRB- cord-014516-r59usk02 2551 32 b.2 b.2 NN cord-014516-r59usk02 2551 33 ) ) -RRB- cord-014516-r59usk02 2551 34 hyperthyroidism hyperthyroidism NN cord-014516-r59usk02 2551 35 , , , cord-014516-r59usk02 2551 36 ( ( -LRB- cord-014516-r59usk02 2551 37 b.3 b.3 LS cord-014516-r59usk02 2551 38 ) ) -RRB- cord-014516-r59usk02 2551 39 hyperadrenocorticism hyperadrenocorticism NN cord-014516-r59usk02 2551 40 and and CC cord-014516-r59usk02 2551 41 ( ( -LRB- cord-014516-r59usk02 2551 42 b.4 b.4 NNP cord-014516-r59usk02 2551 43 ) ) -RRB- cord-014516-r59usk02 2551 44 diabetogenic diabetogenic NNP cord-014516-r59usk02 2551 45 medication medication NN cord-014516-r59usk02 2551 46 ; ; : cord-014516-r59usk02 2551 47 c c NNP cord-014516-r59usk02 2551 48 ) ) -RRB- cord-014516-r59usk02 2551 49 diabetes diabete VBZ cord-014516-r59usk02 2551 50 mellitus mellitus NN cord-014516-r59usk02 2551 51 in in IN cord-014516-r59usk02 2551 52 association association NN cord-014516-r59usk02 2551 53 with with IN cord-014516-r59usk02 2551 54 ( ( -LRB- cord-014516-r59usk02 2551 55 c.1 c.1 NFP cord-014516-r59usk02 2551 56 ) ) -RRB- cord-014516-r59usk02 2551 57 chronic chronic JJ cord-014516-r59usk02 2551 58 kidney kidney NN cord-014516-r59usk02 2551 59 failure failure NN cord-014516-r59usk02 2551 60 and and CC cord-014516-r59usk02 2551 61 ( ( -LRB- cord-014516-r59usk02 2551 62 c.2 c.2 NNP cord-014516-r59usk02 2551 63 ) ) -RRB- cord-014516-r59usk02 2551 64 heart heart NN cord-014516-r59usk02 2551 65 failure failure NN cord-014516-r59usk02 2551 66 ; ; : cord-014516-r59usk02 2551 67 d d LS cord-014516-r59usk02 2551 68 ) ) -RRB- cord-014516-r59usk02 2551 69 ketoacidodic ketoacidodic NNP cord-014516-r59usk02 2551 70 diabetes diabete VBZ cord-014516-r59usk02 2551 71 mellitus mellitus NN cord-014516-r59usk02 2551 72 ; ; : cord-014516-r59usk02 2551 73 e e LS cord-014516-r59usk02 2551 74 ) ) -RRB- cord-014516-r59usk02 2551 75 pancreatitis pancreatitis NN cord-014516-r59usk02 2551 76 . . . cord-014516-r59usk02 2552 1 The the DT cord-014516-r59usk02 2552 2 DSS DSS NNP cord-014516-r59usk02 2552 3 was be VBD cord-014516-r59usk02 2552 4 applied apply VBN cord-014516-r59usk02 2552 5 with with IN cord-014516-r59usk02 2552 6 success success NN cord-014516-r59usk02 2552 7 on on IN cord-014516-r59usk02 2552 8 all all DT cord-014516-r59usk02 2552 9 29 29 CD cord-014516-r59usk02 2552 10 cases case NNS cord-014516-r59usk02 2552 11 , , , cord-014516-r59usk02 2552 12 revealing reveal VBG cord-014516-r59usk02 2552 13 the the DT cord-014516-r59usk02 2552 14 following follow VBG cord-014516-r59usk02 2552 15 diagnoses diagnosis NNS cord-014516-r59usk02 2553 1 / / NFP cord-014516-r59usk02 2554 1 no no DT cord-014516-r59usk02 2554 2 of of IN cord-014516-r59usk02 2554 3 cases case NNS cord-014516-r59usk02 2554 4 : : : cord-014516-r59usk02 2554 5 ( ( -LRB- cord-014516-r59usk02 2554 6 a a LS cord-014516-r59usk02 2554 7 ) ) -RRB- cord-014516-r59usk02 2554 8 -8 -8 NNPS cord-014516-r59usk02 2554 9 , , , cord-014516-r59usk02 2554 10 ( ( -LRB- cord-014516-r59usk02 2554 11 b.1 b.1 NNP cord-014516-r59usk02 2554 12 ) ) -RRB- cord-014516-r59usk02 2554 13 -2 -2 XX cord-014516-r59usk02 2554 14 , , , cord-014516-r59usk02 2555 1 ( ( -LRB- cord-014516-r59usk02 2555 2 b.2 b.2 NNP cord-014516-r59usk02 2555 3 ) ) -RRB- cord-014516-r59usk02 2555 4 -1 -1 NN cord-014516-r59usk02 2555 5 , , , cord-014516-r59usk02 2555 6 ( ( -LRB- cord-014516-r59usk02 2555 7 b.4 b.4 NNP cord-014516-r59usk02 2555 8 ) ) -RRB- cord-014516-r59usk02 2556 1 -8 -8 NNP cord-014516-r59usk02 2556 2 , , , cord-014516-r59usk02 2556 3 ( ( -LRB- cord-014516-r59usk02 2556 4 c.1 c.1 NFP cord-014516-r59usk02 2556 5 ) ) -RRB- cord-014516-r59usk02 2556 6 -3 -3 NNP cord-014516-r59usk02 2556 7 , , , cord-014516-r59usk02 2556 8 ( ( -LRB- cord-014516-r59usk02 2556 9 c.2 c.2 NNP cord-014516-r59usk02 2556 10 ) ) -RRB- cord-014516-r59usk02 2556 11 -3 -3 NNP cord-014516-r59usk02 2556 12 , , , cord-014516-r59usk02 2557 1 ( ( -LRB- cord-014516-r59usk02 2557 2 d d LS cord-014516-r59usk02 2557 3 ) ) -RRB- cord-014516-r59usk02 2557 4 -4 -4 NNP cord-014516-r59usk02 2557 5 . . . cord-014516-r59usk02 2558 1 An an DT cord-014516-r59usk02 2558 2 adequate adequate JJ cord-014516-r59usk02 2558 3 treatment treatment NN cord-014516-r59usk02 2558 4 protocol protocol NN cord-014516-r59usk02 2558 5 requires require VBZ cord-014516-r59usk02 2558 6 an an DT cord-014516-r59usk02 2558 7 accurate accurate JJ cord-014516-r59usk02 2558 8 and and CC cord-014516-r59usk02 2558 9 complete complete JJ cord-014516-r59usk02 2558 10 diagnosis diagnosis NN cord-014516-r59usk02 2558 11 . . . cord-014516-r59usk02 2559 1 Advanced advanced JJ cord-014516-r59usk02 2559 2 computational computational JJ cord-014516-r59usk02 2559 3 systems system NNS cord-014516-r59usk02 2559 4 accompany accompany VBP cord-014516-r59usk02 2559 5 clinicians clinician NNS cord-014516-r59usk02 2559 6 in in IN cord-014516-r59usk02 2559 7 their -PRON- PRP$ cord-014516-r59usk02 2559 8 decision decision NN cord-014516-r59usk02 2559 9 making making NN cord-014516-r59usk02 2559 10 , , , cord-014516-r59usk02 2559 11 leaving leave VBG cord-014516-r59usk02 2559 12 a a DT cord-014516-r59usk02 2559 13 reduced reduce VBN cord-014516-r59usk02 2559 14 space space NN cord-014516-r59usk02 2559 15 for for IN cord-014516-r59usk02 2559 16 medical medical JJ cord-014516-r59usk02 2559 17 errors error NNS cord-014516-r59usk02 2559 18 and and CC cord-014516-r59usk02 2559 19 superfluous superfluous JJ cord-014516-r59usk02 2559 20 , , , cord-014516-r59usk02 2559 21 expensive expensive JJ cord-014516-r59usk02 2559 22 and and CC cord-014516-r59usk02 2559 23 time time NN cord-014516-r59usk02 2559 24 consuming consume VBG cord-014516-r59usk02 2559 25 tests test NNS cord-014516-r59usk02 2559 26 . . . cord-014516-r59usk02 2560 1 Future future JJ cord-014516-r59usk02 2560 2 work work NN cord-014516-r59usk02 2560 3 will will MD cord-014516-r59usk02 2560 4 be be VB cord-014516-r59usk02 2560 5 targeted target VBN cord-014516-r59usk02 2560 6 on on IN cord-014516-r59usk02 2560 7 exploring explore VBG cord-014516-r59usk02 2560 8 the the DT cord-014516-r59usk02 2560 9 possibilities possibility NNS cord-014516-r59usk02 2560 10 of of IN cord-014516-r59usk02 2560 11 combining combine VBG cord-014516-r59usk02 2560 12 the the DT cord-014516-r59usk02 2560 13 DSS DSS NNP cord-014516-r59usk02 2560 14 with with IN cord-014516-r59usk02 2560 15 an an DT cord-014516-r59usk02 2560 16 artificial artificial JJ cord-014516-r59usk02 2560 17 neural neural JJ cord-014516-r59usk02 2560 18 network network NN cord-014516-r59usk02 2560 19 model model NN cord-014516-r59usk02 2560 20 for for IN cord-014516-r59usk02 2560 21 diabetes diabetes NN cord-014516-r59usk02 2560 22 mellitus mellitus NN cord-014516-r59usk02 2560 23 . . . cord-014516-r59usk02 2561 1 This this DT cord-014516-r59usk02 2561 2 can can MD cord-014516-r59usk02 2561 3 be be VB cord-014516-r59usk02 2561 4 the the DT cord-014516-r59usk02 2561 5 foundation foundation NN cord-014516-r59usk02 2561 6 of of IN cord-014516-r59usk02 2561 7 a a DT cord-014516-r59usk02 2561 8 complete complete JJ cord-014516-r59usk02 2561 9 case case NN cord-014516-r59usk02 2561 10 oriented orient VBN cord-014516-r59usk02 2561 11 management management NN cord-014516-r59usk02 2561 12 system system NN cord-014516-r59usk02 2561 13 for for IN cord-014516-r59usk02 2561 14 feline feline JJ cord-014516-r59usk02 2561 15 diabetes diabetes NN cord-014516-r59usk02 2561 16 mellitus mellitus NN cord-014516-r59usk02 2561 17 and and CC cord-014516-r59usk02 2561 18 associated associate VBN cord-014516-r59usk02 2561 19 disorders disorder NNS cord-014516-r59usk02 2561 20 . . . cord-014516-r59usk02 2562 1 No no DT cord-014516-r59usk02 2562 2 conflicts conflict NNS cord-014516-r59usk02 2562 3 of of IN cord-014516-r59usk02 2562 4 interest interest NN cord-014516-r59usk02 2562 5 reported report VBN cord-014516-r59usk02 2562 6 . . . cord-014516-r59usk02 2563 1 Activins Activins NNP cord-014516-r59usk02 2563 2 are be VBP cord-014516-r59usk02 2563 3 cytokines cytokine NNS cord-014516-r59usk02 2563 4 belonging belong VBG cord-014516-r59usk02 2563 5 to to IN cord-014516-r59usk02 2563 6 the the DT cord-014516-r59usk02 2563 7 transforming transform VBG cord-014516-r59usk02 2563 8 growth growth NN cord-014516-r59usk02 2563 9 factor factor NN cord-014516-r59usk02 2563 10 ( ( -LRB- cord-014516-r59usk02 2563 11 TGF)-b tgf)-b JJ cord-014516-r59usk02 2563 12 superfamily superfamily NN cord-014516-r59usk02 2563 13 . . . cord-014516-r59usk02 2564 1 It -PRON- PRP cord-014516-r59usk02 2564 2 is be VBZ cord-014516-r59usk02 2564 3 thought think VBN cord-014516-r59usk02 2564 4 that that IN cord-014516-r59usk02 2564 5 activins activins NNP cord-014516-r59usk02 2564 6 may may MD cord-014516-r59usk02 2564 7 be be VB cord-014516-r59usk02 2564 8 the the DT cord-014516-r59usk02 2564 9 key key JJ cord-014516-r59usk02 2564 10 intermediary intermediary NN cord-014516-r59usk02 2564 11 in in IN cord-014516-r59usk02 2564 12 TGF TGF NNP cord-014516-r59usk02 2564 13 - - HYPH cord-014516-r59usk02 2564 14 b1 b1 NN cord-014516-r59usk02 2564 15 mediated mediate VBN cord-014516-r59usk02 2564 16 fibrotic fibrotic JJ cord-014516-r59usk02 2564 17 response response NN cord-014516-r59usk02 2564 18 . . . cord-014516-r59usk02 2565 1 Activin Activin NNP cord-014516-r59usk02 2565 2 A A NNP cord-014516-r59usk02 2565 3 has have VBZ cord-014516-r59usk02 2565 4 been be VBN cord-014516-r59usk02 2565 5 suggested suggest VBN cord-014516-r59usk02 2565 6 to to TO cord-014516-r59usk02 2565 7 participate participate VB cord-014516-r59usk02 2565 8 in in IN cord-014516-r59usk02 2565 9 the the DT cord-014516-r59usk02 2565 10 pathogenesis pathogenesis NN cord-014516-r59usk02 2565 11 of of IN cord-014516-r59usk02 2565 12 human human JJ cord-014516-r59usk02 2565 13 idiopathic idiopathic JJ cord-014516-r59usk02 2565 14 pulmonary pulmonary JJ cord-014516-r59usk02 2565 15 fibrosis fibrosis NN cord-014516-r59usk02 2565 16 ( ( -LRB- cord-014516-r59usk02 2565 17 IPF IPF NNP cord-014516-r59usk02 2565 18 ) ) -RRB- cord-014516-r59usk02 2565 19 , , , cord-014516-r59usk02 2565 20 but but CC cord-014516-r59usk02 2565 21 studies study NNS cord-014516-r59usk02 2565 22 regarding regard VBG cord-014516-r59usk02 2565 23 the the DT cord-014516-r59usk02 2565 24 role role NN cord-014516-r59usk02 2565 25 of of IN cord-014516-r59usk02 2565 26 activin activin NNP cord-014516-r59usk02 2565 27 B B NNP cord-014516-r59usk02 2565 28 are be VBP cord-014516-r59usk02 2565 29 still still RB cord-014516-r59usk02 2565 30 spares spare NNS cord-014516-r59usk02 2565 31 . . . cord-014516-r59usk02 2566 1 Canine canine JJ cord-014516-r59usk02 2566 2 IPF IPF NNP cord-014516-r59usk02 2566 3 ( ( -LRB- cord-014516-r59usk02 2566 4 CIPF CIPF NNP cord-014516-r59usk02 2566 5 ) ) -RRB- cord-014516-r59usk02 2566 6 is be VBZ cord-014516-r59usk02 2566 7 a a DT cord-014516-r59usk02 2566 8 chronic chronic JJ cord-014516-r59usk02 2566 9 , , , cord-014516-r59usk02 2566 10 incurable incurable JJ cord-014516-r59usk02 2566 11 interstitial interstitial JJ cord-014516-r59usk02 2566 12 lung lung NN cord-014516-r59usk02 2566 13 disease disease NN cord-014516-r59usk02 2566 14 occurring occur VBG cord-014516-r59usk02 2566 15 particularly particularly RB cord-014516-r59usk02 2566 16 in in IN cord-014516-r59usk02 2566 17 West West NNP cord-014516-r59usk02 2566 18 Highland Highland NNP cord-014516-r59usk02 2566 19 White White NNP cord-014516-r59usk02 2566 20 Terriers Terriers NNPS cord-014516-r59usk02 2566 21 ( ( -LRB- cord-014516-r59usk02 2566 22 WHWTs WHWTs NNP cord-014516-r59usk02 2566 23 ) ) -RRB- cord-014516-r59usk02 2566 24 . . . cord-014516-r59usk02 2567 1 During during IN cord-014516-r59usk02 2567 2 the the DT cord-014516-r59usk02 2567 3 disease disease NN cord-014516-r59usk02 2567 4 course course NN cord-014516-r59usk02 2567 5 , , , cord-014516-r59usk02 2567 6 acute acute JJ cord-014516-r59usk02 2567 7 exacerbations exacerbation NNS cord-014516-r59usk02 2567 8 ( ( -LRB- cord-014516-r59usk02 2567 9 AEs AEs NNP cord-014516-r59usk02 2567 10 ) ) -RRB- cord-014516-r59usk02 2567 11 , , , cord-014516-r59usk02 2567 12 with with IN cord-014516-r59usk02 2567 13 poor poor JJ cord-014516-r59usk02 2567 14 prognosis prognosis NN cord-014516-r59usk02 2567 15 , , , cord-014516-r59usk02 2567 16 can can MD cord-014516-r59usk02 2567 17 occur occur VB cord-014516-r59usk02 2567 18 . . . cord-014516-r59usk02 2568 1 Histopathologically histopathologically RB cord-014516-r59usk02 2568 2 AEs AEs NNP cord-014516-r59usk02 2568 3 of of IN cord-014516-r59usk02 2568 4 CIPF CIPF NNP cord-014516-r59usk02 2568 5 are be VBP cord-014516-r59usk02 2568 6 featured feature VBN cord-014516-r59usk02 2568 7 by by IN cord-014516-r59usk02 2568 8 diffuse diffuse JJ cord-014516-r59usk02 2568 9 alveolar alveolar JJ cord-014516-r59usk02 2568 10 damage damage NN cord-014516-r59usk02 2568 11 , , , cord-014516-r59usk02 2568 12 which which WDT cord-014516-r59usk02 2568 13 is be VBZ cord-014516-r59usk02 2568 14 also also RB cord-014516-r59usk02 2568 15 a a DT cord-014516-r59usk02 2568 16 key key JJ cord-014516-r59usk02 2568 17 feature feature NN cord-014516-r59usk02 2568 18 in in IN cord-014516-r59usk02 2568 19 acute acute JJ cord-014516-r59usk02 2568 20 respiratory respiratory JJ cord-014516-r59usk02 2568 21 distress distress NN cord-014516-r59usk02 2568 22 syndrome syndrome NN cord-014516-r59usk02 2568 23 ( ( -LRB- cord-014516-r59usk02 2568 24 ARDS ARDS NNP cord-014516-r59usk02 2568 25 ) ) -RRB- cord-014516-r59usk02 2568 26 . . . cord-014516-r59usk02 2569 1 Our -PRON- PRP$ cord-014516-r59usk02 2569 2 objective objective NN cord-014516-r59usk02 2569 3 was be VBD cord-014516-r59usk02 2569 4 to to TO cord-014516-r59usk02 2569 5 study study VB cord-014516-r59usk02 2569 6 the the DT cord-014516-r59usk02 2569 7 expression expression NN cord-014516-r59usk02 2569 8 of of IN cord-014516-r59usk02 2569 9 activin activin NNP cord-014516-r59usk02 2569 10 A A NNP cord-014516-r59usk02 2569 11 and and CC cord-014516-r59usk02 2569 12 B b NN cord-014516-r59usk02 2569 13 by by IN cord-014516-r59usk02 2569 14 immunohistochemistry immunohistochemistry NN cord-014516-r59usk02 2569 15 in in IN cord-014516-r59usk02 2569 16 the the DT cord-014516-r59usk02 2569 17 lung lung NN cord-014516-r59usk02 2569 18 tissue tissue NN cord-014516-r59usk02 2569 19 of of IN cord-014516-r59usk02 2569 20 CIPF CIPF NNP cord-014516-r59usk02 2569 21 WHWTs WHWTs NNPS cord-014516-r59usk02 2569 22 ( ( -LRB- cord-014516-r59usk02 2569 23 n n NN cord-014516-r59usk02 2569 24 = = SYM cord-014516-r59usk02 2569 25 5 5 CD cord-014516-r59usk02 2569 26 ) ) -RRB- cord-014516-r59usk02 2569 27 , , , cord-014516-r59usk02 2569 28 CIPF CIPF NNP cord-014516-r59usk02 2569 29 WHWTs WHWTs NNPS cord-014516-r59usk02 2569 30 with with IN cord-014516-r59usk02 2569 31 concurrent concurrent JJ cord-014516-r59usk02 2569 32 AE AE NNP cord-014516-r59usk02 2569 33 ( ( -LRB- cord-014516-r59usk02 2569 34 n n NN cord-014516-r59usk02 2569 35 = = SYM cord-014516-r59usk02 2569 36 4 4 CD cord-014516-r59usk02 2569 37 ) ) -RRB- cord-014516-r59usk02 2569 38 , , , cord-014516-r59usk02 2569 39 and and CC cord-014516-r59usk02 2569 40 dogs dog NNS cord-014516-r59usk02 2569 41 of of IN cord-014516-r59usk02 2569 42 various various JJ cord-014516-r59usk02 2569 43 breeds breed NNS cord-014516-r59usk02 2569 44 with with IN cord-014516-r59usk02 2569 45 ARDS ARDS NNP cord-014516-r59usk02 2569 46 ( ( -LRB- cord-014516-r59usk02 2569 47 n n NN cord-014516-r59usk02 2569 48 = = SYM cord-014516-r59usk02 2569 49 4 4 CD cord-014516-r59usk02 2569 50 ) ) -RRB- cord-014516-r59usk02 2569 51 , , , cord-014516-r59usk02 2569 52 and and CC cord-014516-r59usk02 2569 53 to to TO cord-014516-r59usk02 2569 54 compare compare VB cord-014516-r59usk02 2569 55 these these DT cord-014516-r59usk02 2569 56 findings finding NNS cord-014516-r59usk02 2569 57 to to IN cord-014516-r59usk02 2569 58 healthy healthy JJ cord-014516-r59usk02 2569 59 WHWTs whwt NNS cord-014516-r59usk02 2569 60 ( ( -LRB- cord-014516-r59usk02 2569 61 n n NN cord-014516-r59usk02 2569 62 = = SYM cord-014516-r59usk02 2569 63 3 3 CD cord-014516-r59usk02 2569 64 ) ) -RRB- cord-014516-r59usk02 2569 65 . . . cord-014516-r59usk02 2570 1 In in IN cord-014516-r59usk02 2570 2 addition addition NN cord-014516-r59usk02 2570 3 , , , cord-014516-r59usk02 2570 4 western western JJ cord-014516-r59usk02 2570 5 blot blot NN cord-014516-r59usk02 2570 6 analysis analysis NN cord-014516-r59usk02 2570 7 of of IN cord-014516-r59usk02 2570 8 activin activin NNP cord-014516-r59usk02 2570 9 B B NNP cord-014516-r59usk02 2570 10 from from IN cord-014516-r59usk02 2570 11 bronchoalveolar bronchoalveolar NNP cord-014516-r59usk02 2570 12 lavage lavage NN cord-014516-r59usk02 2570 13 fluid fluid NN cord-014516-r59usk02 2570 14 ( ( -LRB- cord-014516-r59usk02 2570 15 BALF BALF NNP cord-014516-r59usk02 2570 16 ) ) -RRB- cord-014516-r59usk02 2570 17 of of IN cord-014516-r59usk02 2570 18 CIPF CIPF NNP cord-014516-r59usk02 2570 19 WHWTs WHWTs NNPS cord-014516-r59usk02 2570 20 ( ( -LRB- cord-014516-r59usk02 2570 21 n n NN cord-014516-r59usk02 2570 22 = = SYM cord-014516-r59usk02 2570 23 6 6 CD cord-014516-r59usk02 2570 24 ) ) -RRB- cord-014516-r59usk02 2570 25 and and CC cord-014516-r59usk02 2570 26 healthy healthy JJ cord-014516-r59usk02 2570 27 WHWTs WHWTs NNPS cord-014516-r59usk02 2570 28 ( ( -LRB- cord-014516-r59usk02 2570 29 n n NN cord-014516-r59usk02 2570 30 = = SYM cord-014516-r59usk02 2570 31 6 6 CD cord-014516-r59usk02 2570 32 ) ) -RRB- cord-014516-r59usk02 2570 33 was be VBD cord-014516-r59usk02 2570 34 conducted conduct VBN cord-014516-r59usk02 2570 35 . . . cord-014516-r59usk02 2571 1 We -PRON- PRP cord-014516-r59usk02 2571 2 demonstrated demonstrate VBD cord-014516-r59usk02 2571 3 that that IN cord-014516-r59usk02 2571 4 activin activin NNP cord-014516-r59usk02 2571 5 B B NNP cord-014516-r59usk02 2571 6 , , , cord-014516-r59usk02 2571 7 but but CC cord-014516-r59usk02 2571 8 not not RB cord-014516-r59usk02 2571 9 activin activin NNP cord-014516-r59usk02 2571 10 A A NNP cord-014516-r59usk02 2571 11 , , , cord-014516-r59usk02 2571 12 is be VBZ cord-014516-r59usk02 2571 13 strongly strongly RB cord-014516-r59usk02 2571 14 expressed express VBN cord-014516-r59usk02 2571 15 in in IN cord-014516-r59usk02 2571 16 the the DT cord-014516-r59usk02 2571 17 altered alter VBN cord-014516-r59usk02 2571 18 alveolar alveolar JJ cord-014516-r59usk02 2571 19 epithelium epithelium NN cord-014516-r59usk02 2571 20 in in IN cord-014516-r59usk02 2571 21 lungs lung NNS cord-014516-r59usk02 2571 22 of of IN cord-014516-r59usk02 2571 23 diseased diseased JJ cord-014516-r59usk02 2571 24 WHWTs whwt NNS cord-014516-r59usk02 2571 25 as as RB cord-014516-r59usk02 2571 26 well well RB cord-014516-r59usk02 2571 27 as as IN cord-014516-r59usk02 2571 28 in in IN cord-014516-r59usk02 2571 29 ARDS ARDS NNP cord-014516-r59usk02 2571 30 lungs lung NNS cord-014516-r59usk02 2571 31 . . . cord-014516-r59usk02 2572 1 Furthermore furthermore RB cord-014516-r59usk02 2572 2 , , , cord-014516-r59usk02 2572 3 activin activin NNP cord-014516-r59usk02 2572 4 B B NNP cord-014516-r59usk02 2572 5 was be VBD cord-014516-r59usk02 2572 6 detected detect VBN cord-014516-r59usk02 2572 7 in in IN cord-014516-r59usk02 2572 8 BALF BALF NNP cord-014516-r59usk02 2572 9 of of IN cord-014516-r59usk02 2572 10 CIPF CIPF NNP cord-014516-r59usk02 2572 11 WHWTs WHWTs NNPS cord-014516-r59usk02 2572 12 , , , cord-014516-r59usk02 2572 13 most most RBS cord-014516-r59usk02 2572 14 notably notably RB cord-014516-r59usk02 2572 15 in in IN cord-014516-r59usk02 2572 16 samples sample NNS cord-014516-r59usk02 2572 17 from from IN cord-014516-r59usk02 2572 18 dogs dog NNS cord-014516-r59usk02 2572 19 with with IN cord-014516-r59usk02 2572 20 AE AE NNP cord-014516-r59usk02 2572 21 , , , cord-014516-r59usk02 2572 22 but but CC cord-014516-r59usk02 2572 23 not not RB cord-014516-r59usk02 2572 24 in in IN cord-014516-r59usk02 2572 25 BALF BALF NNP cord-014516-r59usk02 2572 26 of of IN cord-014516-r59usk02 2572 27 healthy healthy JJ cord-014516-r59usk02 2572 28 WHWTs whwt NNS cord-014516-r59usk02 2572 29 . . . cord-014516-r59usk02 2573 1 This this DT cord-014516-r59usk02 2573 2 novel novel NN cord-014516-r59usk02 2573 3 finding finding NN cord-014516-r59usk02 2573 4 suggests suggest VBZ cord-014516-r59usk02 2573 5 that that IN cord-014516-r59usk02 2573 6 activin activin NNP cord-014516-r59usk02 2573 7 B B NNP cord-014516-r59usk02 2573 8 participates participate VBZ cord-014516-r59usk02 2573 9 in in IN cord-014516-r59usk02 2573 10 the the DT cord-014516-r59usk02 2573 11 pathophysiology pathophysiology NN cord-014516-r59usk02 2573 12 of of IN cord-014516-r59usk02 2573 13 CIPF CIPF NNP cord-014516-r59usk02 2573 14 and and CC cord-014516-r59usk02 2573 15 might may MD cord-014516-r59usk02 2573 16 act act VB cord-014516-r59usk02 2573 17 as as IN cord-014516-r59usk02 2573 18 a a DT cord-014516-r59usk02 2573 19 potential potential JJ cord-014516-r59usk02 2573 20 marker marker NN cord-014516-r59usk02 2573 21 of of IN cord-014516-r59usk02 2573 22 alveolar alveolar JJ cord-014516-r59usk02 2573 23 epithelial epithelial JJ cord-014516-r59usk02 2573 24 damage damage NN cord-014516-r59usk02 2573 25 . . . cord-014516-r59usk02 2574 1 No no DT cord-014516-r59usk02 2574 2 conflicts conflict NNS cord-014516-r59usk02 2574 3 of of IN cord-014516-r59usk02 2574 4 interest interest NN cord-014516-r59usk02 2574 5 reported report VBN cord-014516-r59usk02 2574 6 . . . cord-014516-r59usk02 2575 1 Dogs dog NNS cord-014516-r59usk02 2575 2 of of IN cord-014516-r59usk02 2575 3 the the DT cord-014516-r59usk02 2575 4 breed breed NN cord-014516-r59usk02 2575 5 Nova Nova NNP cord-014516-r59usk02 2575 6 Scotia Scotia NNP cord-014516-r59usk02 2575 7 Duck Duck NNP cord-014516-r59usk02 2575 8 Tolling Tolling NNP cord-014516-r59usk02 2575 9 Retriever Retriever NNP cord-014516-r59usk02 2575 10 ( ( -LRB- cord-014516-r59usk02 2575 11 NSDTR NSDTR NNP cord-014516-r59usk02 2575 12 ) ) -RRB- cord-014516-r59usk02 2575 13 are be VBP cord-014516-r59usk02 2575 14 affected affect VBN cord-014516-r59usk02 2575 15 by by IN cord-014516-r59usk02 2575 16 several several JJ cord-014516-r59usk02 2575 17 immune immune NN cord-014516-r59usk02 2575 18 - - HYPH cord-014516-r59usk02 2575 19 mediated mediate VBN cord-014516-r59usk02 2575 20 diseases disease NNS cord-014516-r59usk02 2575 21 , , , cord-014516-r59usk02 2575 22 in in IN cord-014516-r59usk02 2575 23 particular particular JJ cord-014516-r59usk02 2575 24 steroid steroid JJ cord-014516-r59usk02 2575 25 - - HYPH cord-014516-r59usk02 2575 26 responsive responsive JJ cord-014516-r59usk02 2575 27 meningitis meningitis NN cord-014516-r59usk02 2575 28 - - HYPH cord-014516-r59usk02 2575 29 arteritis arteritis NN cord-014516-r59usk02 2575 30 ( ( -LRB- cord-014516-r59usk02 2575 31 SRMA SRMA NNP cord-014516-r59usk02 2575 32 ) ) -RRB- cord-014516-r59usk02 2575 33 and and CC cord-014516-r59usk02 2575 34 an an DT cord-014516-r59usk02 2575 35 immune immune NN cord-014516-r59usk02 2575 36 - - HYPH cord-014516-r59usk02 2575 37 mediated mediate VBN cord-014516-r59usk02 2575 38 rheumatic rheumatic JJ cord-014516-r59usk02 2575 39 disease disease NN cord-014516-r59usk02 2575 40 ( ( -LRB- cord-014516-r59usk02 2575 41 IMRD IMRD NNP cord-014516-r59usk02 2575 42 ) ) -RRB- cord-014516-r59usk02 2575 43 . . . cord-014516-r59usk02 2576 1 IMRD IMRD NNP cord-014516-r59usk02 2576 2 is be VBZ cord-014516-r59usk02 2576 3 a a DT cord-014516-r59usk02 2576 4 systemic systemic JJ cord-014516-r59usk02 2576 5 lupus lupus NN cord-014516-r59usk02 2576 6 erythematosus erythematosus NN cord-014516-r59usk02 2576 7 - - HYPH cord-014516-r59usk02 2576 8 related relate VBN cord-014516-r59usk02 2576 9 disease disease NN cord-014516-r59usk02 2576 10 characterized characterize VBN cord-014516-r59usk02 2576 11 by by IN cord-014516-r59usk02 2576 12 chronic chronic JJ cord-014516-r59usk02 2576 13 stiffness stiffness NN cord-014516-r59usk02 2576 14 and and CC cord-014516-r59usk02 2576 15 pain pain NN cord-014516-r59usk02 2576 16 in in IN cord-014516-r59usk02 2576 17 several several JJ cord-014516-r59usk02 2576 18 joints joint NNS cord-014516-r59usk02 2576 19 . . . cord-014516-r59usk02 2577 1 The the DT cord-014516-r59usk02 2577 2 aim aim NN cord-014516-r59usk02 2577 3 of of IN cord-014516-r59usk02 2577 4 this this DT cord-014516-r59usk02 2577 5 study study NN cord-014516-r59usk02 2577 6 was be VBD cord-014516-r59usk02 2577 7 to to TO cord-014516-r59usk02 2577 8 investigate investigate VB cord-014516-r59usk02 2577 9 the the DT cord-014516-r59usk02 2577 10 morbidity morbidity NN cord-014516-r59usk02 2577 11 in in IN cord-014516-r59usk02 2577 12 NSDTRs nsdtr NNS cord-014516-r59usk02 2577 13 and and CC cord-014516-r59usk02 2577 14 to to TO cord-014516-r59usk02 2577 15 test test VB cord-014516-r59usk02 2577 16 the the DT cord-014516-r59usk02 2577 17 hypothesis hypothesis NN cord-014516-r59usk02 2577 18 that that IN cord-014516-r59usk02 2577 19 NSDTRs nsdtr NNS cord-014516-r59usk02 2577 20 are be VBP cord-014516-r59usk02 2577 21 predisposed predisposed JJ cord-014516-r59usk02 2577 22 to to IN cord-014516-r59usk02 2577 23 SRMA SRMA NNP cord-014516-r59usk02 2577 24 and and CC cord-014516-r59usk02 2577 25 IMRD IMRD NNP cord-014516-r59usk02 2577 26 . . . cord-014516-r59usk02 2578 1 Insurance insurance NN cord-014516-r59usk02 2578 2 data datum NNS cord-014516-r59usk02 2578 3 from from IN cord-014516-r59usk02 2578 4 a a DT cord-014516-r59usk02 2578 5 Swedish swedish JJ cord-014516-r59usk02 2578 6 insurance insurance NN cord-014516-r59usk02 2578 7 company company NN cord-014516-r59usk02 2578 8 ( ( -LRB- cord-014516-r59usk02 2578 9 Agria Agria NNP cord-014516-r59usk02 2578 10 insurance insurance NN cord-014516-r59usk02 2578 11 company company NN cord-014516-r59usk02 2578 12 , , , cord-014516-r59usk02 2578 13 Stockholm Stockholm NNP cord-014516-r59usk02 2578 14 , , , cord-014516-r59usk02 2578 15 Sweden Sweden NNP cord-014516-r59usk02 2578 16 ) ) -RRB- cord-014516-r59usk02 2578 17 from from IN cord-014516-r59usk02 2578 18 1995 1995 CD cord-014516-r59usk02 2578 19 - - SYM cord-014516-r59usk02 2578 20 2006 2006 CD cord-014516-r59usk02 2578 21 was be VBD cord-014516-r59usk02 2578 22 used use VBN cord-014516-r59usk02 2578 23 for for IN cord-014516-r59usk02 2578 24 the the DT cord-014516-r59usk02 2578 25 study study NN cord-014516-r59usk02 2578 26 . . . cord-014516-r59usk02 2579 1 Approximately approximately RB cord-014516-r59usk02 2579 2 one one CD cord-014516-r59usk02 2579 3 third third NN cord-014516-r59usk02 2579 4 of of IN cord-014516-r59usk02 2579 5 Swedish swedish JJ cord-014516-r59usk02 2579 6 dogs dog NNS cord-014516-r59usk02 2579 7 are be VBP cord-014516-r59usk02 2579 8 insured insure VBN cord-014516-r59usk02 2579 9 by by IN cord-014516-r59usk02 2579 10 Agria Agria NNP cord-014516-r59usk02 2579 11 and and CC cord-014516-r59usk02 2579 12 the the DT cord-014516-r59usk02 2579 13 insurance insurance NN cord-014516-r59usk02 2579 14 database database NN cord-014516-r59usk02 2579 15 is be VBZ cord-014516-r59usk02 2579 16 a a DT cord-014516-r59usk02 2579 17 validated validated JJ cord-014516-r59usk02 2579 18 tool tool NN cord-014516-r59usk02 2579 19 for for IN cord-014516-r59usk02 2579 20 epidemiological epidemiological JJ cord-014516-r59usk02 2579 21 studies study NNS cord-014516-r59usk02 2579 22 . . . cord-014516-r59usk02 2580 1 Assessment assessment NN cord-014516-r59usk02 2580 2 of of IN cord-014516-r59usk02 2580 3 morbidity morbidity NN cord-014516-r59usk02 2580 4 was be VBD cord-014516-r59usk02 2580 5 based base VBN cord-014516-r59usk02 2580 6 on on IN cord-014516-r59usk02 2580 7 veterinary veterinary JJ cord-014516-r59usk02 2580 8 care care NN cord-014516-r59usk02 2580 9 events event NNS cord-014516-r59usk02 2580 10 . . . cord-014516-r59usk02 2581 1 Disease disease NN cord-014516-r59usk02 2581 2 diagnoses diagnosis NNS cord-014516-r59usk02 2581 3 were be VBD cord-014516-r59usk02 2581 4 grouped group VBN cord-014516-r59usk02 2581 5 in in IN cord-014516-r59usk02 2581 6 both both DT cord-014516-r59usk02 2581 7 general general JJ cord-014516-r59usk02 2581 8 and and CC cord-014516-r59usk02 2581 9 specific specific JJ cord-014516-r59usk02 2581 10 disease disease NN cord-014516-r59usk02 2581 11 categories category NNS cord-014516-r59usk02 2581 12 . . . cord-014516-r59usk02 2582 1 Individual individual JJ cord-014516-r59usk02 2582 2 diagnoses diagnosis NNS cord-014516-r59usk02 2582 3 that that WDT cord-014516-r59usk02 2582 4 were be VBD cord-014516-r59usk02 2582 5 likely likely JJ cord-014516-r59usk02 2582 6 to to TO cord-014516-r59usk02 2582 7 represent represent VB cord-014516-r59usk02 2582 8 IMRD IMRD NNP cord-014516-r59usk02 2582 9 were be VBD cord-014516-r59usk02 2582 10 combined combine VBN cord-014516-r59usk02 2582 11 . . . cord-014516-r59usk02 2583 1 Morbidity morbidity NN cord-014516-r59usk02 2583 2 was be VBD cord-014516-r59usk02 2583 3 defined define VBN cord-014516-r59usk02 2583 4 as as IN cord-014516-r59usk02 2583 5 incidence incidence NN cord-014516-r59usk02 2583 6 rates rate NNS cord-014516-r59usk02 2583 7 and and CC cord-014516-r59usk02 2583 8 presented present VBN cord-014516-r59usk02 2583 9 as as IN cord-014516-r59usk02 2583 10 number number NN cord-014516-r59usk02 2583 11 of of IN cord-014516-r59usk02 2583 12 cases case NNS cord-014516-r59usk02 2583 13 per per IN cord-014516-r59usk02 2583 14 10 10 CD cord-014516-r59usk02 2583 15 000 000 CD cord-014516-r59usk02 2583 16 dog dog NN cord-014516-r59usk02 2583 17 years year NNS cord-014516-r59usk02 2583 18 at at IN cord-014516-r59usk02 2583 19 risk risk NN cord-014516-r59usk02 2583 20 ( ( -LRB- cord-014516-r59usk02 2583 21 DYAR DYAR NNP cord-014516-r59usk02 2583 22 ) ) -RRB- cord-014516-r59usk02 2583 23 . . . cord-014516-r59usk02 2584 1 Relative relative JJ cord-014516-r59usk02 2584 2 risk risk NN cord-014516-r59usk02 2584 3 ( ( -LRB- cord-014516-r59usk02 2584 4 RR rr NN cord-014516-r59usk02 2584 5 ) ) -RRB- cord-014516-r59usk02 2584 6 for for IN cord-014516-r59usk02 2584 7 NSDTRs nsdtr NNS cord-014516-r59usk02 2584 8 compared compare VBN cord-014516-r59usk02 2584 9 to to IN cord-014516-r59usk02 2584 10 other other JJ cord-014516-r59usk02 2584 11 breeds breed NNS cord-014516-r59usk02 2584 12 combined combine VBN cord-014516-r59usk02 2584 13 was be VBD cord-014516-r59usk02 2584 14 calculated calculate VBN cord-014516-r59usk02 2584 15 . . . cord-014516-r59usk02 2585 1 The the DT cord-014516-r59usk02 2585 2 study study NN cord-014516-r59usk02 2585 3 included include VBD cord-014516-r59usk02 2585 4 445 445 CD cord-014516-r59usk02 2585 5 336 336 CD cord-014516-r59usk02 2585 6 dogs dog NNS cord-014516-r59usk02 2585 7 , , , cord-014516-r59usk02 2585 8 2890 2890 CD cord-014516-r59usk02 2585 9 were be VBD cord-014516-r59usk02 2585 10 NSDTRs nsdtr NNS cord-014516-r59usk02 2585 11 . . . cord-014516-r59usk02 2586 1 The the DT cord-014516-r59usk02 2586 2 most most RBS cord-014516-r59usk02 2586 3 common common JJ cord-014516-r59usk02 2586 4 general general JJ cord-014516-r59usk02 2586 5 causes cause NNS cord-014516-r59usk02 2586 6 of of IN cord-014516-r59usk02 2586 7 veterinary veterinary JJ cord-014516-r59usk02 2586 8 care care NN cord-014516-r59usk02 2586 9 for for IN cord-014516-r59usk02 2586 10 NSDTRs nsdtr NNS cord-014516-r59usk02 2586 11 were be VBD cord-014516-r59usk02 2586 12 injuries injury NNS cord-014516-r59usk02 2586 13 followed follow VBN cord-014516-r59usk02 2586 14 by by IN cord-014516-r59usk02 2586 15 gastrointestinal gastrointestinal JJ cord-014516-r59usk02 2586 16 and and CC cord-014516-r59usk02 2586 17 musculoskeletal musculoskeletal JJ cord-014516-r59usk02 2586 18 disorders disorder NNS cord-014516-r59usk02 2586 19 with with IN cord-014516-r59usk02 2586 20 significant significant JJ cord-014516-r59usk02 2586 21 increased increased JJ cord-014516-r59usk02 2586 22 risk risk NN cord-014516-r59usk02 2586 23 ( ( -LRB- cord-014516-r59usk02 2586 24 RRs rrs NN cord-014516-r59usk02 2586 25 between between IN cord-014516-r59usk02 2586 26 1.2 1.2 CD cord-014516-r59usk02 2586 27 and and CC cord-014516-r59usk02 2586 28 1.3 1.3 CD cord-014516-r59usk02 2586 29 ) ) -RRB- cord-014516-r59usk02 2586 30 for for IN cord-014516-r59usk02 2586 31 NSDTRs nsdtr NNS cord-014516-r59usk02 2586 32 compared compare VBN cord-014516-r59usk02 2586 33 to to IN cord-014516-r59usk02 2586 34 other other JJ cord-014516-r59usk02 2586 35 breeds breed NNS cord-014516-r59usk02 2586 36 . . . cord-014516-r59usk02 2587 1 The the DT cord-014516-r59usk02 2587 2 highest high JJS cord-014516-r59usk02 2587 3 relative relative JJ cord-014516-r59usk02 2587 4 risk risk NN cord-014516-r59usk02 2587 5 for for IN cord-014516-r59usk02 2587 6 NSDTRs nsdtr NNS cord-014516-r59usk02 2587 7 was be VBD cord-014516-r59usk02 2587 8 for for IN cord-014516-r59usk02 2587 9 systemic systemic JJ cord-014516-r59usk02 2587 10 lupus lupus NN cord-014516-r59usk02 2587 11 erythematosus erythematosus NN cord-014516-r59usk02 2587 12 ( ( -LRB- cord-014516-r59usk02 2587 13 RR RR NNP cord-014516-r59usk02 2587 14 19.0 19.0 CD cord-014516-r59usk02 2587 15 ) ) -RRB- cord-014516-r59usk02 2587 16 . . . cord-014516-r59usk02 2588 1 Compared compare VBN cord-014516-r59usk02 2588 2 to to IN cord-014516-r59usk02 2588 3 other other JJ cord-014516-r59usk02 2588 4 breeds breed NNS cord-014516-r59usk02 2588 5 , , , cord-014516-r59usk02 2588 6 NSDTRs nsdtr NNS cord-014516-r59usk02 2588 7 had have VBD cord-014516-r59usk02 2588 8 an an DT cord-014516-r59usk02 2588 9 increased increase VBN cord-014516-r59usk02 2588 10 risk risk NN cord-014516-r59usk02 2588 11 for for IN cord-014516-r59usk02 2588 12 SRMA SRMA NNP cord-014516-r59usk02 2588 13 ( ( -LRB- cord-014516-r59usk02 2588 14 RR RR NNP cord-014516-r59usk02 2588 15 11.5 11.5 CD cord-014516-r59usk02 2588 16 ) ) -RRB- cord-014516-r59usk02 2588 17 and and CC cord-014516-r59usk02 2588 18 IMRD IMRD NNP cord-014516-r59usk02 2588 19 ( ( -LRB- cord-014516-r59usk02 2588 20 RR RR NNP cord-014516-r59usk02 2588 21 11.8 11.8 CD cord-014516-r59usk02 2588 22 ) ) -RRB- cord-014516-r59usk02 2588 23 with with IN cord-014516-r59usk02 2588 24 an an DT cord-014516-r59usk02 2588 25 incidence incidence NN cord-014516-r59usk02 2588 26 rate rate NN cord-014516-r59usk02 2588 27 of of IN cord-014516-r59usk02 2588 28 19.6 19.6 CD cord-014516-r59usk02 2588 29 cases case NNS cord-014516-r59usk02 2588 30 per per IN cord-014516-r59usk02 2588 31 10 10 CD cord-014516-r59usk02 2588 32 000 000 CD cord-014516-r59usk02 2588 33 DYAR DYAR NNS cord-014516-r59usk02 2588 34 for for IN cord-014516-r59usk02 2588 35 SRMA SRMA NNP cord-014516-r59usk02 2588 36 and and CC cord-014516-r59usk02 2588 37 8.8 8.8 CD cord-014516-r59usk02 2588 38 cases case NNS cord-014516-r59usk02 2588 39 per per IN cord-014516-r59usk02 2588 40 10 10 CD cord-014516-r59usk02 2588 41 000 000 CD cord-014516-r59usk02 2588 42 DYAR DYAR NNS cord-014516-r59usk02 2588 43 for for IN cord-014516-r59usk02 2588 44 IMRD IMRD NNP cord-014516-r59usk02 2588 45 . . . cord-014516-r59usk02 2589 1 The the DT cord-014516-r59usk02 2589 2 incidence incidence NN cord-014516-r59usk02 2589 3 rate rate NN cord-014516-r59usk02 2589 4 for for IN cord-014516-r59usk02 2589 5 SRMA SRMA NNP cord-014516-r59usk02 2589 6 and and CC cord-014516-r59usk02 2589 7 IMRD IMRD NNP cord-014516-r59usk02 2589 8 in in IN cord-014516-r59usk02 2589 9 NSDTRs nsdtr NNS cord-014516-r59usk02 2589 10 were be VBD cord-014516-r59usk02 2589 11 also also RB cord-014516-r59usk02 2589 12 compared compare VBN cord-014516-r59usk02 2589 13 to to IN cord-014516-r59usk02 2589 14 dogs dog NNS cord-014516-r59usk02 2589 15 of of IN cord-014516-r59usk02 2589 16 other other JJ cord-014516-r59usk02 2589 17 retriever retriever NN cord-014516-r59usk02 2589 18 breeds breed NNS cord-014516-r59usk02 2589 19 . . . cord-014516-r59usk02 2590 1 The the DT cord-014516-r59usk02 2590 2 comparison comparison NN cord-014516-r59usk02 2590 3 revealed reveal VBD cord-014516-r59usk02 2590 4 that that IN cord-014516-r59usk02 2590 5 NSDTRs nsdtr NNS cord-014516-r59usk02 2590 6 also also RB cord-014516-r59usk02 2590 7 had have VBD cord-014516-r59usk02 2590 8 a a DT cord-014516-r59usk02 2590 9 significant significant JJ cord-014516-r59usk02 2590 10 increased increase VBN cord-014516-r59usk02 2590 11 risk risk NN cord-014516-r59usk02 2590 12 for for IN cord-014516-r59usk02 2590 13 both both DT cord-014516-r59usk02 2590 14 SRMA SRMA NNP cord-014516-r59usk02 2590 15 ( ( -LRB- cord-014516-r59usk02 2590 16 RR RR NNP cord-014516-r59usk02 2590 17 20.8 20.8 CD cord-014516-r59usk02 2590 18 ) ) -RRB- cord-014516-r59usk02 2590 19 and and CC cord-014516-r59usk02 2590 20 IMRD IMRD NNP cord-014516-r59usk02 2590 21 ( ( -LRB- cord-014516-r59usk02 2590 22 RR RR NNP cord-014516-r59usk02 2590 23 10.1 10.1 CD cord-014516-r59usk02 2590 24 ) ) -RRB- cord-014516-r59usk02 2590 25 when when WRB cord-014516-r59usk02 2590 26 compared compare VBN cord-014516-r59usk02 2590 27 to to IN cord-014516-r59usk02 2590 28 other other JJ cord-014516-r59usk02 2590 29 retrievers retriever NNS cord-014516-r59usk02 2590 30 only only RB cord-014516-r59usk02 2590 31 . . . cord-014516-r59usk02 2591 1 This this DT cord-014516-r59usk02 2591 2 study study NN cord-014516-r59usk02 2591 3 is be VBZ cord-014516-r59usk02 2591 4 the the DT cord-014516-r59usk02 2591 5 first first JJ cord-014516-r59usk02 2591 6 to to TO cord-014516-r59usk02 2591 7 investigate investigate VB cord-014516-r59usk02 2591 8 the the DT cord-014516-r59usk02 2591 9 morbidity morbidity NN cord-014516-r59usk02 2591 10 for for IN cord-014516-r59usk02 2591 11 IMRD IMRD NNP cord-014516-r59usk02 2591 12 in in IN cord-014516-r59usk02 2591 13 NSDTRs nsdtr NNS cord-014516-r59usk02 2591 14 , , , cord-014516-r59usk02 2591 15 which which WDT cord-014516-r59usk02 2591 16 is be VBZ cord-014516-r59usk02 2591 17 important important JJ cord-014516-r59usk02 2591 18 for for IN cord-014516-r59usk02 2591 19 further further JJ cord-014516-r59usk02 2591 20 research research NN cord-014516-r59usk02 2591 21 and and CC cord-014516-r59usk02 2591 22 breeding breeding NN cord-014516-r59usk02 2591 23 practice practice NN cord-014516-r59usk02 2591 24 . . . cord-014516-r59usk02 2592 1 For for IN cord-014516-r59usk02 2592 2 several several JJ cord-014516-r59usk02 2592 3 reasons reason NNS cord-014516-r59usk02 2592 4 the the DT cord-014516-r59usk02 2592 5 incidence incidence NN cord-014516-r59usk02 2592 6 rates rate NNS cord-014516-r59usk02 2592 7 might may MD cord-014516-r59usk02 2592 8 be be VB cord-014516-r59usk02 2592 9 underestimated underestimate VBN cord-014516-r59usk02 2592 10 and and CC cord-014516-r59usk02 2592 11 exact exact JJ cord-014516-r59usk02 2592 12 numbers number NNS cord-014516-r59usk02 2592 13 should should MD cord-014516-r59usk02 2592 14 be be VB cord-014516-r59usk02 2592 15 interpreted interpret VBN cord-014516-r59usk02 2592 16 with with IN cord-014516-r59usk02 2592 17 caution caution NN cord-014516-r59usk02 2592 18 . . . cord-014516-r59usk02 2593 1 However however RB cord-014516-r59usk02 2593 2 underestimation underestimation NN cord-014516-r59usk02 2593 3 of of IN cord-014516-r59usk02 2593 4 incidence incidence NN cord-014516-r59usk02 2593 5 rates rate NNS cord-014516-r59usk02 2593 6 should should MD cord-014516-r59usk02 2593 7 not not RB cord-014516-r59usk02 2593 8 differ differ VB cord-014516-r59usk02 2593 9 between between IN cord-014516-r59usk02 2593 10 dogs dog NNS cord-014516-r59usk02 2593 11 of of IN cord-014516-r59usk02 2593 12 different different JJ cord-014516-r59usk02 2593 13 breeds breed NNS cord-014516-r59usk02 2593 14 , , , cord-014516-r59usk02 2593 15 therefore therefore RB cord-014516-r59usk02 2593 16 not not RB cord-014516-r59usk02 2593 17 affecting affect VBG cord-014516-r59usk02 2593 18 the the DT cord-014516-r59usk02 2593 19 risk risk NN cord-014516-r59usk02 2593 20 calculations calculation NNS cord-014516-r59usk02 2593 21 . . . cord-014516-r59usk02 2594 1 It -PRON- PRP cord-014516-r59usk02 2594 2 can can MD cord-014516-r59usk02 2594 3 be be VB cord-014516-r59usk02 2594 4 concluded conclude VBN cord-014516-r59usk02 2594 5 that that IN cord-014516-r59usk02 2594 6 NSDTRs nsdtr NNS cord-014516-r59usk02 2594 7 are be VBP cord-014516-r59usk02 2594 8 predisposed predisposed JJ cord-014516-r59usk02 2594 9 to to IN cord-014516-r59usk02 2594 10 the the DT cord-014516-r59usk02 2594 11 diseases disease NNS cord-014516-r59usk02 2594 12 SRMA SRMA NNP cord-014516-r59usk02 2594 13 and and CC cord-014516-r59usk02 2594 14 IMRD IMRD NNP cord-014516-r59usk02 2594 15 with with IN cord-014516-r59usk02 2594 16 an an DT cord-014516-r59usk02 2594 17 increased increase VBN cord-014516-r59usk02 2594 18 risk risk NN cord-014516-r59usk02 2594 19 compared compare VBN cord-014516-r59usk02 2594 20 to to IN cord-014516-r59usk02 2594 21 other other JJ cord-014516-r59usk02 2594 22 breeds breed NNS cord-014516-r59usk02 2594 23 and and CC cord-014516-r59usk02 2594 24 to to IN cord-014516-r59usk02 2594 25 other other JJ cord-014516-r59usk02 2594 26 retrievers retriever NNS cord-014516-r59usk02 2594 27 . . . cord-014516-r59usk02 2595 1 Brenda Brenda NNP cord-014516-r59usk02 2595 2 N. N. NNP cord-014516-r59usk02 2595 3 Bonnett Bonnett NNP cord-014516-r59usk02 2595 4 consults consult VBZ cord-014516-r59usk02 2595 5 with with IN cord-014516-r59usk02 2595 6 Agria Agria NNP cord-014516-r59usk02 2595 7 insurance insurance NN cord-014516-r59usk02 2595 8 company company NN cord-014516-r59usk02 2595 9 on on IN cord-014516-r59usk02 2595 10 various various JJ cord-014516-r59usk02 2595 11 projects project NNS cord-014516-r59usk02 2595 12 . . . cord-014516-r59usk02 2596 1 Agria Agria NNP cord-014516-r59usk02 2596 2 insurance insurance NN cord-014516-r59usk02 2596 3 company company NN cord-014516-r59usk02 2596 4 has have VBZ cord-014516-r59usk02 2596 5 also also RB cord-014516-r59usk02 2596 6 funded fund VBN cord-014516-r59usk02 2596 7 work work NN cord-014516-r59usk02 2596 8 leading lead VBG cord-014516-r59usk02 2596 9 to to IN cord-014516-r59usk02 2596 10 the the DT cord-014516-r59usk02 2596 11 development development NN cord-014516-r59usk02 2596 12 of of IN cord-014516-r59usk02 2596 13 the the DT cord-014516-r59usk02 2596 14 insurance insurance NN cord-014516-r59usk02 2596 15 data datum NNS cord-014516-r59usk02 2596 16 base base NN cord-014516-r59usk02 2596 17 that that WDT cord-014516-r59usk02 2596 18 my -PRON- PRP$ cord-014516-r59usk02 2596 19 study study NN cord-014516-r59usk02 2596 20 was be VBD cord-014516-r59usk02 2596 21 based base VBN cord-014516-r59usk02 2596 22 on on IN cord-014516-r59usk02 2596 23 . . . cord-014516-r59usk02 2597 1 Canine canine JJ cord-014516-r59usk02 2597 2 infectious infectious JJ cord-014516-r59usk02 2597 3 respiratory respiratory JJ cord-014516-r59usk02 2597 4 disease disease NN cord-014516-r59usk02 2597 5 ( ( -LRB- cord-014516-r59usk02 2597 6 CIRD CIRD NNP cord-014516-r59usk02 2597 7 ) ) -RRB- cord-014516-r59usk02 2597 8 is be VBZ cord-014516-r59usk02 2597 9 a a DT cord-014516-r59usk02 2597 10 multifactorial multifactorial JJ cord-014516-r59usk02 2597 11 contagious contagious JJ cord-014516-r59usk02 2597 12 disease disease NN cord-014516-r59usk02 2597 13 caused cause VBN cord-014516-r59usk02 2597 14 by by IN cord-014516-r59usk02 2597 15 respiratory respiratory JJ cord-014516-r59usk02 2597 16 viruses virus NNS cord-014516-r59usk02 2597 17 and and CC cord-014516-r59usk02 2597 18 selected select VBN cord-014516-r59usk02 2597 19 bacterial bacterial JJ cord-014516-r59usk02 2597 20 pathogens pathogen NNS cord-014516-r59usk02 2597 21 . . . cord-014516-r59usk02 2598 1 CIRD CIRD NNP cord-014516-r59usk02 2598 2 has have VBZ cord-014516-r59usk02 2598 3 been be VBN cord-014516-r59usk02 2598 4 shown show VBN cord-014516-r59usk02 2598 5 to to TO cord-014516-r59usk02 2598 6 be be VB cord-014516-r59usk02 2598 7 a a DT cord-014516-r59usk02 2598 8 predisposing predisposing JJ cord-014516-r59usk02 2598 9 factor factor NN cord-014516-r59usk02 2598 10 in in IN cord-014516-r59usk02 2598 11 the the DT cord-014516-r59usk02 2598 12 development development NN cord-014516-r59usk02 2598 13 of of IN cord-014516-r59usk02 2598 14 bacterial bacterial JJ cord-014516-r59usk02 2598 15 pneumonia pneumonia NN cord-014516-r59usk02 2598 16 ( ( -LRB- cord-014516-r59usk02 2598 17 BP BP NNP cord-014516-r59usk02 2598 18 ) ) -RRB- cord-014516-r59usk02 2598 19 in in IN cord-014516-r59usk02 2598 20 dogs dog NNS cord-014516-r59usk02 2598 21 housed house VBN cord-014516-r59usk02 2598 22 in in IN cord-014516-r59usk02 2598 23 dense dense JJ cord-014516-r59usk02 2598 24 populations population NNS cord-014516-r59usk02 2598 25 such such JJ cord-014516-r59usk02 2598 26 as as IN cord-014516-r59usk02 2598 27 kennels kennel NNS cord-014516-r59usk02 2598 28 and and CC cord-014516-r59usk02 2598 29 rehoming rehome VBG cord-014516-r59usk02 2598 30 centers center NNS cord-014516-r59usk02 2598 31 . . . cord-014516-r59usk02 2599 1 The the DT cord-014516-r59usk02 2599 2 aim aim NN cord-014516-r59usk02 2599 3 of of IN cord-014516-r59usk02 2599 4 this this DT cord-014516-r59usk02 2599 5 study study NN cord-014516-r59usk02 2599 6 was be VBD cord-014516-r59usk02 2599 7 to to TO cord-014516-r59usk02 2599 8 determine determine VB cord-014516-r59usk02 2599 9 the the DT cord-014516-r59usk02 2599 10 prevalence prevalence NN cord-014516-r59usk02 2599 11 of of IN cord-014516-r59usk02 2599 12 viral viral JJ cord-014516-r59usk02 2599 13 co co NN cord-014516-r59usk02 2599 14 - - NN cord-014516-r59usk02 2599 15 infection infection NN cord-014516-r59usk02 2599 16 and and CC cord-014516-r59usk02 2599 17 to to TO cord-014516-r59usk02 2599 18 assess assess VB cord-014516-r59usk02 2599 19 its -PRON- PRP$ cord-014516-r59usk02 2599 20 effects effect NNS cord-014516-r59usk02 2599 21 on on IN cord-014516-r59usk02 2599 22 disease disease NN cord-014516-r59usk02 2599 23 severity severity NN cord-014516-r59usk02 2599 24 in in IN cord-014516-r59usk02 2599 25 household household NN cord-014516-r59usk02 2599 26 dogs dog NNS cord-014516-r59usk02 2599 27 diagnosed diagnose VBN cord-014516-r59usk02 2599 28 with with IN cord-014516-r59usk02 2599 29 BP BP NNP cord-014516-r59usk02 2599 30 . . . cord-014516-r59usk02 2600 1 A a DT cord-014516-r59usk02 2600 2 prospective prospective JJ cord-014516-r59usk02 2600 3 cross cross JJ cord-014516-r59usk02 2600 4 - - JJ cord-014516-r59usk02 2600 5 sectional sectional JJ cord-014516-r59usk02 2600 6 observational observational JJ cord-014516-r59usk02 2600 7 study study NN cord-014516-r59usk02 2600 8 was be VBD cord-014516-r59usk02 2600 9 conducted conduct VBN cord-014516-r59usk02 2600 10 and and CC cord-014516-r59usk02 2600 11 20 20 CD cord-014516-r59usk02 2600 12 dogs dog NNS cord-014516-r59usk02 2600 13 diagnosed diagnose VBN cord-014516-r59usk02 2600 14 with with IN cord-014516-r59usk02 2600 15 BP BP NNP cord-014516-r59usk02 2600 16 caused cause VBN cord-014516-r59usk02 2600 17 by by IN cord-014516-r59usk02 2600 18 opportunistic opportunistic JJ cord-014516-r59usk02 2600 19 bacteria bacteria NNS cord-014516-r59usk02 2600 20 were be VBD cord-014516-r59usk02 2600 21 included include VBN cord-014516-r59usk02 2600 22 . . . cord-014516-r59usk02 2601 1 13 13 CD cord-014516-r59usk02 2601 2 dogs dog NNS cord-014516-r59usk02 2601 3 with with IN cord-014516-r59usk02 2601 4 chronic chronic NN cord-014516-r59usk02 2601 5 ( ( -LRB- cord-014516-r59usk02 2601 6 > > NFP cord-014516-r59usk02 2601 7 30 30 CD cord-014516-r59usk02 2601 8 days day NNS cord-014516-r59usk02 2601 9 ) ) -RRB- cord-014516-r59usk02 2601 10 tracheobronchitis tracheobronchitis NN cord-014516-r59usk02 2601 11 caused cause VBN cord-014516-r59usk02 2601 12 by by IN cord-014516-r59usk02 2601 13 Bordetella Bordetella NNP cord-014516-r59usk02 2601 14 bronchiseptica bronchiseptica NNP cord-014516-r59usk02 2601 15 were be VBD cord-014516-r59usk02 2601 16 included include VBN cord-014516-r59usk02 2601 17 as as IN cord-014516-r59usk02 2601 18 controls control NNS cord-014516-r59usk02 2601 19 for for IN cord-014516-r59usk02 2601 20 virus virus NN cord-014516-r59usk02 2601 21 analysis analysis NN cord-014516-r59usk02 2601 22 . . . cord-014516-r59usk02 2602 1 Diagnosis diagnosis NN cord-014516-r59usk02 2602 2 was be VBD cord-014516-r59usk02 2602 3 confirmed confirm VBN cord-014516-r59usk02 2602 4 by by IN cord-014516-r59usk02 2602 5 thorough thorough JJ cord-014516-r59usk02 2602 6 clinical clinical JJ cord-014516-r59usk02 2602 7 examinations examination NNS cord-014516-r59usk02 2602 8 as as RB cord-014516-r59usk02 2602 9 well well RB cord-014516-r59usk02 2602 10 as as IN cord-014516-r59usk02 2602 11 with with IN cord-014516-r59usk02 2602 12 cytological cytological JJ cord-014516-r59usk02 2602 13 and and CC cord-014516-r59usk02 2602 14 bacterial bacterial JJ cord-014516-r59usk02 2602 15 analysis analysis NN cord-014516-r59usk02 2602 16 of of IN cord-014516-r59usk02 2602 17 bronchoalveolar bronchoalveolar NNP cord-014516-r59usk02 2602 18 lavage lavage NNP cord-014516-r59usk02 2602 19 ( ( -LRB- cord-014516-r59usk02 2602 20 BAL BAL NNP cord-014516-r59usk02 2602 21 ) ) -RRB- cord-014516-r59usk02 2602 22 or or CC cord-014516-r59usk02 2602 23 transtracheal transtracheal NN cord-014516-r59usk02 2602 24 wash wash NNP cord-014516-r59usk02 2602 25 ( ( -LRB- cord-014516-r59usk02 2602 26 TTW TTW NNP cord-014516-r59usk02 2602 27 ) ) -RRB- cord-014516-r59usk02 2602 28 samples sample NNS cord-014516-r59usk02 2602 29 . . . cord-014516-r59usk02 2603 1 Canine canine JJ cord-014516-r59usk02 2603 2 parainfluenssavirus parainfluenssavirus NN cord-014516-r59usk02 2603 3 ( ( -LRB- cord-014516-r59usk02 2603 4 CPIV CPIV NNP cord-014516-r59usk02 2603 5 ) ) -RRB- cord-014516-r59usk02 2603 6 , , , cord-014516-r59usk02 2603 7 Canine canine JJ cord-014516-r59usk02 2603 8 adenovirus adenovirus NN cord-014516-r59usk02 2603 9 , , , cord-014516-r59usk02 2603 10 Canine canine JJ cord-014516-r59usk02 2603 11 herpesvirus herpesvirus NN cord-014516-r59usk02 2603 12 , , , cord-014516-r59usk02 2603 13 Canine canine JJ cord-014516-r59usk02 2603 14 distempervirus distemperviru NNS cord-014516-r59usk02 2603 15 , , , cord-014516-r59usk02 2603 16 Canine canine JJ cord-014516-r59usk02 2603 17 respiratory respiratory JJ cord-014516-r59usk02 2603 18 coronavirus coronavirus NN cord-014516-r59usk02 2603 19 ( ( -LRB- cord-014516-r59usk02 2603 20 CRCoV crcov NN cord-014516-r59usk02 2603 21 ) ) -RRB- cord-014516-r59usk02 2603 22 and and CC cord-014516-r59usk02 2603 23 Canine Canine NNP cord-014516-r59usk02 2603 24 pneumovirus pneumoviru NNS cord-014516-r59usk02 2603 25 were be VBD cord-014516-r59usk02 2603 26 analysed analyse VBN cord-014516-r59usk02 2603 27 in in IN cord-014516-r59usk02 2603 28 BAL BAL NNP cord-014516-r59usk02 2603 29 or or CC cord-014516-r59usk02 2603 30 TTW TTW NNP cord-014516-r59usk02 2603 31 samples sample NNS cord-014516-r59usk02 2603 32 using use VBG cord-014516-r59usk02 2603 33 RT RT NNP cord-014516-r59usk02 2603 34 - - HYPH cord-014516-r59usk02 2603 35 PCR PCR NNP cord-014516-r59usk02 2603 36 assay assay NN cord-014516-r59usk02 2603 37 . . . cord-014516-r59usk02 2604 1 CPIV CPIV NNP cord-014516-r59usk02 2604 2 was be VBD cord-014516-r59usk02 2604 3 detected detect VBN cord-014516-r59usk02 2604 4 in in IN cord-014516-r59usk02 2604 5 7/20 7/20 CD cord-014516-r59usk02 2604 6 ( ( -LRB- cord-014516-r59usk02 2604 7 35 35 CD cord-014516-r59usk02 2604 8 % % NN cord-014516-r59usk02 2604 9 ) ) -RRB- cord-014516-r59usk02 2604 10 and and CC cord-014516-r59usk02 2604 11 CRCoV crcov NN cord-014516-r59usk02 2604 12 in in IN cord-014516-r59usk02 2604 13 1/20 1/20 CD cord-014516-r59usk02 2604 14 ( ( -LRB- cord-014516-r59usk02 2604 15 5 5 CD cord-014516-r59usk02 2604 16 % % NN cord-014516-r59usk02 2604 17 ) ) -RRB- cord-014516-r59usk02 2604 18 respiratory respiratory JJ cord-014516-r59usk02 2604 19 samples sample NNS cord-014516-r59usk02 2604 20 in in IN cord-014516-r59usk02 2604 21 dogs dog NNS cord-014516-r59usk02 2604 22 with with IN cord-014516-r59usk02 2604 23 BP BP NNP cord-014516-r59usk02 2604 24 . . . cord-014516-r59usk02 2605 1 Respiratory respiratory JJ cord-014516-r59usk02 2605 2 viruses virus NNS cord-014516-r59usk02 2605 3 were be VBD cord-014516-r59usk02 2605 4 not not RB cord-014516-r59usk02 2605 5 detected detect VBN cord-014516-r59usk02 2605 6 in in IN cord-014516-r59usk02 2605 7 dogs dog NNS cord-014516-r59usk02 2605 8 with with IN cord-014516-r59usk02 2605 9 chronic chronic JJ cord-014516-r59usk02 2605 10 tracheobronchitis tracheobronchitis NN cord-014516-r59usk02 2605 11 . . . cord-014516-r59usk02 2606 1 There there EX cord-014516-r59usk02 2606 2 were be VBD cord-014516-r59usk02 2606 3 no no DT cord-014516-r59usk02 2606 4 significant significant JJ cord-014516-r59usk02 2606 5 differences difference NNS cord-014516-r59usk02 2606 6 in in IN cord-014516-r59usk02 2606 7 the the DT cord-014516-r59usk02 2606 8 duration duration NN cord-014516-r59usk02 2606 9 of of IN cord-014516-r59usk02 2606 10 hospitalization hospitalization NN cord-014516-r59usk02 2607 1 ( ( -LRB- cord-014516-r59usk02 2607 2 p p NN cord-014516-r59usk02 2607 3 = = SYM cord-014516-r59usk02 2607 4 0.427 0.427 CD cord-014516-r59usk02 2607 5 ) ) -RRB- cord-014516-r59usk02 2607 6 or or CC cord-014516-r59usk02 2607 7 arterial arterial JJ cord-014516-r59usk02 2607 8 paO pao JJ cord-014516-r59usk02 2607 9 2 2 CD cord-014516-r59usk02 2607 10 at at IN cord-014516-r59usk02 2607 11 presentation presentation NN cord-014516-r59usk02 2608 1 ( ( -LRB- cord-014516-r59usk02 2608 2 p p NN cord-014516-r59usk02 2608 3 = = SYM cord-014516-r59usk02 2608 4 0.343 0.343 CD cord-014516-r59usk02 2608 5 ) ) -RRB- cord-014516-r59usk02 2608 6 between between IN cord-014516-r59usk02 2608 7 BP BP NNP cord-014516-r59usk02 2608 8 dogs dog NNS cord-014516-r59usk02 2608 9 with with IN cord-014516-r59usk02 2608 10 and and CC cord-014516-r59usk02 2608 11 without without IN cord-014516-r59usk02 2608 12 a a DT cord-014516-r59usk02 2608 13 viral viral JJ cord-014516-r59usk02 2608 14 co co NN cord-014516-r59usk02 2608 15 - - NN cord-014516-r59usk02 2608 16 infection infection NN cord-014516-r59usk02 2608 17 . . . cord-014516-r59usk02 2609 1 These these DT cord-014516-r59usk02 2609 2 results result NNS cord-014516-r59usk02 2609 3 indicate indicate VBP cord-014516-r59usk02 2609 4 that that IN cord-014516-r59usk02 2609 5 co co NNS cord-014516-r59usk02 2609 6 - - NNS cord-014516-r59usk02 2609 7 infections infection NNS cord-014516-r59usk02 2609 8 with with IN cord-014516-r59usk02 2609 9 respiratory respiratory JJ cord-014516-r59usk02 2609 10 viruses virus NNS cord-014516-r59usk02 2609 11 are be VBP cord-014516-r59usk02 2609 12 common common JJ cord-014516-r59usk02 2609 13 also also RB cord-014516-r59usk02 2609 14 in in IN cord-014516-r59usk02 2609 15 household household NN cord-014516-r59usk02 2609 16 dogs dog NNS cord-014516-r59usk02 2609 17 with with IN cord-014516-r59usk02 2609 18 BP BP NNP cord-014516-r59usk02 2609 19 . . . cord-014516-r59usk02 2610 1 Additionally additionally RB cord-014516-r59usk02 2610 2 , , , cord-014516-r59usk02 2610 3 viral viral JJ cord-014516-r59usk02 2610 4 co co NNS cord-014516-r59usk02 2610 5 - - NNS cord-014516-r59usk02 2610 6 infections infection NNS cord-014516-r59usk02 2610 7 did do VBD cord-014516-r59usk02 2610 8 not not RB cord-014516-r59usk02 2610 9 cause cause VB cord-014516-r59usk02 2610 10 a a DT cord-014516-r59usk02 2610 11 more more RBR cord-014516-r59usk02 2610 12 severe severe JJ cord-014516-r59usk02 2610 13 course course NN cord-014516-r59usk02 2610 14 of of IN cord-014516-r59usk02 2610 15 BP BP NNP cord-014516-r59usk02 2610 16 . . . cord-014516-r59usk02 2611 1 The the DT cord-014516-r59usk02 2611 2 author author NN cord-014516-r59usk02 2611 3 's 's POS cord-014516-r59usk02 2611 4 researcjh researcjh NNS cord-014516-r59usk02 2611 5 is be VBZ cord-014516-r59usk02 2611 6 financially financially RB cord-014516-r59usk02 2611 7 supported support VBN cord-014516-r59usk02 2611 8 by by IN cord-014516-r59usk02 2611 9 the the DT cord-014516-r59usk02 2611 10 Finnish Finnish NNP cord-014516-r59usk02 2611 11 Foundation Foundation NNP cord-014516-r59usk02 2611 12 of of IN cord-014516-r59usk02 2611 13 Veterinary Veterinary NNP cord-014516-r59usk02 2611 14 R R NNP cord-014516-r59usk02 2611 15 and and CC cord-014516-r59usk02 2611 16 the the DT cord-014516-r59usk02 2611 17 Finnish Finnish NNP cord-014516-r59usk02 2611 18 Veterinary Veterinary NNP cord-014516-r59usk02 2611 19 Foundation Foundation NNP cord-014516-r59usk02 2611 20 . . . cord-014516-r59usk02 2612 1 ESVIM ESVIM NNP cord-014516-r59usk02 2612 2 - - HYPH cord-014516-r59usk02 2612 3 P-4 P-4 NNP cord-014516-r59usk02 2612 4 CAUSES causes NN cord-014516-r59usk02 2612 5 OF of IN cord-014516-r59usk02 2612 6 CANINE canine JJ cord-014516-r59usk02 2612 7 ANEMIA anemia NN cord-014516-r59usk02 2612 8 IN in IN cord-014516-r59usk02 2612 9 TAIWAN TAIWAN NNP cord-014516-r59usk02 2612 10 : : : cord-014516-r59usk02 2613 1 A a DT cord-014516-r59usk02 2613 2 FIVE five CD cord-014516-r59usk02 2613 3 - - HYPH cord-014516-r59usk02 2613 4 YEAR year NN cord-014516-r59usk02 2613 5 RETROSPECTIVE RETROSPECTIVE NNP cord-014516-r59usk02 2613 6 SURVEY SURVEY NNP cord-014516-r59usk02 2613 7 . . . cord-014516-r59usk02 2614 1 E.C.Y. E.C.Y. NNP cord-014516-r59usk02 2614 2 Lin Lin NNP cord-014516-r59usk02 2614 3 1 1 CD cord-014516-r59usk02 2614 4 , , , cord-014516-r59usk02 2614 5 P.C. P.C. NNP cord-014516-r59usk02 2614 6 Liu Liu NNP cord-014516-r59usk02 2614 7 1 1 CD cord-014516-r59usk02 2614 8 , , , cord-014516-r59usk02 2614 9 L.L. L.L. NNP cord-014516-r59usk02 2614 10 Chueh Chueh NNP cord-014516-r59usk02 2614 11 1 1 CD cord-014516-r59usk02 2614 12 , , , cord-014516-r59usk02 2614 13 B.L. B.L. NNP cord-014516-r59usk02 2614 14 Su Su NNP cord-014516-r59usk02 2614 15 2 2 CD cord-014516-r59usk02 2614 16 . . . cord-014516-r59usk02 2615 1 1 1 CD cord-014516-r59usk02 2615 2 Graduate Graduate NNP cord-014516-r59usk02 2615 3 Institute Institute NNP cord-014516-r59usk02 2615 4 of of IN cord-014516-r59usk02 2615 5 Veterinary Veterinary NNP cord-014516-r59usk02 2615 6 Medicine Medicine NNP cord-014516-r59usk02 2615 7 , , , cord-014516-r59usk02 2615 8 National National NNP cord-014516-r59usk02 2615 9 Taiwan Taiwan NNP cord-014516-r59usk02 2615 10 University University NNP cord-014516-r59usk02 2615 11 , , , cord-014516-r59usk02 2615 12 Taipei Taipei NNP cord-014516-r59usk02 2615 13 , , , cord-014516-r59usk02 2615 14 Taiwan Taiwan NNP cord-014516-r59usk02 2615 15 , , , cord-014516-r59usk02 2615 16 2 2 CD cord-014516-r59usk02 2615 17 Institute Institute NNP cord-014516-r59usk02 2615 18 of of IN cord-014516-r59usk02 2615 19 Veterinary Veterinary NNP cord-014516-r59usk02 2615 20 Clinical Clinical NNP cord-014516-r59usk02 2615 21 Sciences Sciences NNPS cord-014516-r59usk02 2615 22 , , , cord-014516-r59usk02 2615 23 National National NNP cord-014516-r59usk02 2615 24 Taiwan Taiwan NNP cord-014516-r59usk02 2615 25 University University NNP cord-014516-r59usk02 2615 26 , , , cord-014516-r59usk02 2615 27 Taipei Taipei NNP cord-014516-r59usk02 2615 28 , , , cord-014516-r59usk02 2615 29 Taiwan Taiwan NNP cord-014516-r59usk02 2615 30 Anemia anemia NN cord-014516-r59usk02 2615 31 is be VBZ cord-014516-r59usk02 2615 32 a a DT cord-014516-r59usk02 2615 33 common common JJ cord-014516-r59usk02 2615 34 hematologic hematologic JJ cord-014516-r59usk02 2615 35 disorder disorder NN cord-014516-r59usk02 2615 36 in in IN cord-014516-r59usk02 2615 37 dogs dog NNS cord-014516-r59usk02 2615 38 , , , cord-014516-r59usk02 2615 39 however however RB cord-014516-r59usk02 2615 40 , , , cord-014516-r59usk02 2615 41 few few JJ cord-014516-r59usk02 2615 42 data datum NNS cord-014516-r59usk02 2615 43 are be VBP cord-014516-r59usk02 2615 44 available available JJ cord-014516-r59usk02 2615 45 regarding regard VBG cord-014516-r59usk02 2615 46 epidemiology epidemiology NN cord-014516-r59usk02 2615 47 and and CC cord-014516-r59usk02 2615 48 causes cause NNS cord-014516-r59usk02 2615 49 in in IN cord-014516-r59usk02 2615 50 Taiwan Taiwan NNP cord-014516-r59usk02 2615 51 . . . cord-014516-r59usk02 2616 1 To to TO cord-014516-r59usk02 2616 2 investigate investigate VB cord-014516-r59usk02 2616 3 the the DT cord-014516-r59usk02 2616 4 causes cause NNS cord-014516-r59usk02 2616 5 of of IN cord-014516-r59usk02 2616 6 anemia anemia NN cord-014516-r59usk02 2616 7 , , , cord-014516-r59usk02 2616 8 3174 3174 CD cord-014516-r59usk02 2616 9 anemic anemic JJ cord-014516-r59usk02 2616 10 cases case NNS cord-014516-r59usk02 2616 11 ( ( -LRB- cord-014516-r59usk02 2616 12 PCV PCV NNP cord-014516-r59usk02 2616 13 < < XX cord-014516-r59usk02 2616 14 37 37 CD cord-014516-r59usk02 2616 15 % % NN cord-014516-r59usk02 2616 16 ) ) -RRB- cord-014516-r59usk02 2616 17 collected collect VBN cord-014516-r59usk02 2616 18 between between IN cord-014516-r59usk02 2616 19 January January NNP cord-014516-r59usk02 2616 20 2008 2008 CD cord-014516-r59usk02 2616 21 and and CC cord-014516-r59usk02 2616 22 December December NNP cord-014516-r59usk02 2616 23 2012 2012 CD cord-014516-r59usk02 2616 24 at at IN cord-014516-r59usk02 2616 25 National National NNP cord-014516-r59usk02 2616 26 Taiwan Taiwan NNP cord-014516-r59usk02 2616 27 University University NNP cord-014516-r59usk02 2616 28 Veterinary Veterinary NNP cord-014516-r59usk02 2616 29 Hospital Hospital NNP cord-014516-r59usk02 2616 30 ( ( -LRB- cord-014516-r59usk02 2616 31 NTUVH NTUVH NNP cord-014516-r59usk02 2616 32 ) ) -RRB- cord-014516-r59usk02 2616 33 were be VBD cord-014516-r59usk02 2616 34 analyzed analyze VBN cord-014516-r59usk02 2616 35 . . . cord-014516-r59usk02 2617 1 Most Most JJS cord-014516-r59usk02 2617 2 dogs dog NNS cord-014516-r59usk02 2617 3 ( ( -LRB- cord-014516-r59usk02 2617 4 72.1 72.1 CD cord-014516-r59usk02 2617 5 % % NN cord-014516-r59usk02 2617 6 , , , cord-014516-r59usk02 2617 7 n n NN cord-014516-r59usk02 2617 8 = = SYM cord-014516-r59usk02 2617 9 2889 2889 CD cord-014516-r59usk02 2617 10 ) ) -RRB- cord-014516-r59usk02 2617 11 presented present VBN cord-014516-r59usk02 2617 12 with with IN cord-014516-r59usk02 2617 13 a a DT cord-014516-r59usk02 2617 14 mild mild JJ cord-014516-r59usk02 2617 15 form form NN cord-014516-r59usk02 2617 16 ( ( -LRB- cord-014516-r59usk02 2617 17 25%≦PCV<37 25%≦pcv<37 CD cord-014516-r59usk02 2617 18 % % NN cord-014516-r59usk02 2617 19 ) ) -RRB- cord-014516-r59usk02 2617 20 , , , cord-014516-r59usk02 2617 21 which which WDT cord-014516-r59usk02 2617 22 was be VBD cord-014516-r59usk02 2617 23 followed follow VBN cord-014516-r59usk02 2617 24 by by IN cord-014516-r59usk02 2617 25 a a DT cord-014516-r59usk02 2617 26 moderate moderate JJ cord-014516-r59usk02 2617 27 form form NN cord-014516-r59usk02 2617 28 ( ( -LRB- cord-014516-r59usk02 2617 29 15%≦PCV<25 15%≦pcv<25 CD cord-014516-r59usk02 2617 30 % % NN cord-014516-r59usk02 2617 31 ; ; : cord-014516-r59usk02 2617 32 20.8 20.8 CD cord-014516-r59usk02 2617 33 % % NN cord-014516-r59usk02 2617 34 , , , cord-014516-r59usk02 2617 35 n n NN cord-014516-r59usk02 2617 36 = = SYM cord-014516-r59usk02 2617 37 660 660 CD cord-014516-r59usk02 2617 38 ) ) -RRB- cord-014516-r59usk02 2617 39 and and CC cord-014516-r59usk02 2617 40 a a DT cord-014516-r59usk02 2617 41 severe severe JJ cord-014516-r59usk02 2617 42 form form NN cord-014516-r59usk02 2617 43 ( ( -LRB- cord-014516-r59usk02 2617 44 PCV<15 pcv<15 NN cord-014516-r59usk02 2617 45 % % NN cord-014516-r59usk02 2617 46 ; ; : cord-014516-r59usk02 2617 47 7.1 7.1 CD cord-014516-r59usk02 2617 48 % % NN cord-014516-r59usk02 2617 49 , , , cord-014516-r59usk02 2617 50 n n NN cord-014516-r59usk02 2617 51 = = SYM cord-014516-r59usk02 2617 52 225 225 CD cord-014516-r59usk02 2617 53 ) ) -RRB- cord-014516-r59usk02 2617 54 . . . cord-014516-r59usk02 2618 1 Among among IN cord-014516-r59usk02 2618 2 the the DT cord-014516-r59usk02 2618 3 2037 2037 CD cord-014516-r59usk02 2618 4 dogs dog NNS cord-014516-r59usk02 2618 5 with with IN cord-014516-r59usk02 2618 6 identifiable identifiable JJ cord-014516-r59usk02 2618 7 causes cause NNS cord-014516-r59usk02 2618 8 , , , cord-014516-r59usk02 2618 9 70.4 70.4 CD cord-014516-r59usk02 2618 10 % % NN cord-014516-r59usk02 2618 11 ( ( -LRB- cord-014516-r59usk02 2618 12 1435 1435 CD cord-014516-r59usk02 2618 13 dogs dog NNS cord-014516-r59usk02 2618 14 ) ) -RRB- cord-014516-r59usk02 2618 15 were be VBD cord-014516-r59usk02 2618 16 induced induce VBN cord-014516-r59usk02 2618 17 by by IN cord-014516-r59usk02 2618 18 single single JJ cord-014516-r59usk02 2618 19 cause cause NN cord-014516-r59usk02 2618 20 , , , cord-014516-r59usk02 2618 21 whereas whereas IN cord-014516-r59usk02 2618 22 29.6 29.6 CD cord-014516-r59usk02 2618 23 % % NN cord-014516-r59usk02 2618 24 ( ( -LRB- cord-014516-r59usk02 2618 25 602 602 CD cord-014516-r59usk02 2618 26 dogs dog NNS cord-014516-r59usk02 2618 27 ) ) -RRB- cord-014516-r59usk02 2618 28 by by IN cord-014516-r59usk02 2618 29 multiple multiple JJ cord-014516-r59usk02 2618 30 causes cause NNS cord-014516-r59usk02 2618 31 . . . cord-014516-r59usk02 2619 1 Neoplasia neoplasia NN cord-014516-r59usk02 2619 2 - - HYPH cord-014516-r59usk02 2619 3 related relate VBN cord-014516-r59usk02 2619 4 anemia anemia NN cord-014516-r59usk02 2619 5 ( ( -LRB- cord-014516-r59usk02 2619 6 n n NN cord-014516-r59usk02 2619 7 = = SYM cord-014516-r59usk02 2619 8 460 460 CD cord-014516-r59usk02 2619 9 ) ) -RRB- cord-014516-r59usk02 2619 10 , , , cord-014516-r59usk02 2619 11 infectious infectious JJ cord-014516-r59usk02 2619 12 pathogens pathogen NNS cord-014516-r59usk02 2619 13 - - HYPH cord-014516-r59usk02 2619 14 related relate VBN cord-014516-r59usk02 2619 15 anemia anemia NN cord-014516-r59usk02 2619 16 ( ( -LRB- cord-014516-r59usk02 2619 17 n n NN cord-014516-r59usk02 2619 18 = = SYM cord-014516-r59usk02 2619 19 287 287 CD cord-014516-r59usk02 2619 20 ) ) -RRB- cord-014516-r59usk02 2619 21 , , , cord-014516-r59usk02 2619 22 renal renal JJ cord-014516-r59usk02 2619 23 disease disease NN cord-014516-r59usk02 2619 24 - - HYPH cord-014516-r59usk02 2619 25 related relate VBN cord-014516-r59usk02 2619 26 anemia anemia NN cord-014516-r59usk02 2619 27 ( ( -LRB- cord-014516-r59usk02 2619 28 n n NN cord-014516-r59usk02 2619 29 = = SYM cord-014516-r59usk02 2619 30 251 251 CD cord-014516-r59usk02 2619 31 ) ) -RRB- cord-014516-r59usk02 2619 32 and and CC cord-014516-r59usk02 2619 33 post post AFX cord-014516-r59usk02 2619 34 - - JJ cord-014516-r59usk02 2619 35 surgery/ surgery/ JJ cord-014516-r59usk02 2619 36 traumarelated traumarelated JJ cord-014516-r59usk02 2619 37 anemia anemia NN cord-014516-r59usk02 2619 38 ( ( -LRB- cord-014516-r59usk02 2619 39 n n NN cord-014516-r59usk02 2619 40 = = SYM cord-014516-r59usk02 2619 41 182 182 CD cord-014516-r59usk02 2619 42 ) ) -RRB- cord-014516-r59usk02 2619 43 account account VBP cord-014516-r59usk02 2619 44 for for IN cord-014516-r59usk02 2619 45 32.1 32.1 CD cord-014516-r59usk02 2619 46 , , , cord-014516-r59usk02 2619 47 20.0 20.0 CD cord-014516-r59usk02 2619 48 , , , cord-014516-r59usk02 2619 49 17.6 17.6 CD cord-014516-r59usk02 2619 50 and and CC cord-014516-r59usk02 2619 51 12.7 12.7 CD cord-014516-r59usk02 2619 52 % % NN cord-014516-r59usk02 2619 53 of of IN cord-014516-r59usk02 2619 54 single single JJ cord-014516-r59usk02 2619 55 - - HYPH cord-014516-r59usk02 2619 56 cause cause NN cord-014516-r59usk02 2619 57 cases case NNS cord-014516-r59usk02 2619 58 , , , cord-014516-r59usk02 2619 59 respectively respectively RB cord-014516-r59usk02 2619 60 . . . cord-014516-r59usk02 2620 1 Furthermore furthermore RB cord-014516-r59usk02 2620 2 , , , cord-014516-r59usk02 2620 3 123 123 CD cord-014516-r59usk02 2620 4 of of IN cord-014516-r59usk02 2620 5 them -PRON- PRP cord-014516-r59usk02 2620 6 ( ( -LRB- cord-014516-r59usk02 2620 7 8.6 8.6 CD cord-014516-r59usk02 2620 8 % % NN cord-014516-r59usk02 2620 9 ) ) -RRB- cord-014516-r59usk02 2620 10 presented present VBN cord-014516-r59usk02 2620 11 with with IN cord-014516-r59usk02 2620 12 severe severe JJ cord-014516-r59usk02 2620 13 anemia anemia NN cord-014516-r59usk02 2620 14 . . . cord-014516-r59usk02 2621 1 Severe severe JJ cord-014516-r59usk02 2621 2 anemia anemia NN cord-014516-r59usk02 2621 3 primarily primarily RB cord-014516-r59usk02 2621 4 resulted result VBD cord-014516-r59usk02 2621 5 from from IN cord-014516-r59usk02 2621 6 infectious infectious JJ cord-014516-r59usk02 2621 7 disease disease NN cord-014516-r59usk02 2621 8 - - HYPH cord-014516-r59usk02 2621 9 related relate VBN cord-014516-r59usk02 2621 10 anemia anemia NN cord-014516-r59usk02 2621 11 ( ( -LRB- cord-014516-r59usk02 2621 12 61.8 61.8 CD cord-014516-r59usk02 2621 13 % % NN cord-014516-r59usk02 2621 14 ) ) -RRB- cord-014516-r59usk02 2621 15 , , , cord-014516-r59usk02 2621 16 followed follow VBN cord-014516-r59usk02 2621 17 by by IN cord-014516-r59usk02 2621 18 IMHA IMHA NNP cord-014516-r59usk02 2621 19 ( ( -LRB- cord-014516-r59usk02 2621 20 11.4 11.4 CD cord-014516-r59usk02 2621 21 % % NN cord-014516-r59usk02 2621 22 ) ) -RRB- cord-014516-r59usk02 2621 23 , , , cord-014516-r59usk02 2621 24 and and CC cord-014516-r59usk02 2621 25 tumor tumor NN cord-014516-r59usk02 2621 26 - - HYPH cord-014516-r59usk02 2621 27 related relate VBN cord-014516-r59usk02 2621 28 anemia anemia NN cord-014516-r59usk02 2621 29 ( ( -LRB- cord-014516-r59usk02 2621 30 11.4 11.4 CD cord-014516-r59usk02 2621 31 % % NN cord-014516-r59usk02 2621 32 ) ) -RRB- cord-014516-r59usk02 2621 33 . . . cord-014516-r59usk02 2622 1 Of of IN cord-014516-r59usk02 2622 2 the the DT cord-014516-r59usk02 2622 3 76 76 CD cord-014516-r59usk02 2622 4 infectious infectious JJ cord-014516-r59usk02 2622 5 disease disease NN cord-014516-r59usk02 2622 6 - - HYPH cord-014516-r59usk02 2622 7 related relate VBN cord-014516-r59usk02 2622 8 severe severe JJ cord-014516-r59usk02 2622 9 anemic anemic JJ cord-014516-r59usk02 2622 10 dogs dog NNS cord-014516-r59usk02 2622 11 , , , cord-014516-r59usk02 2622 12 the the DT cord-014516-r59usk02 2622 13 most most RBS cord-014516-r59usk02 2622 14 common common JJ cord-014516-r59usk02 2622 15 diagnosed diagnosed JJ cord-014516-r59usk02 2622 16 pathogen pathogen NN cord-014516-r59usk02 2622 17 was be VBD cord-014516-r59usk02 2622 18 Babesia Babesia NNP cord-014516-r59usk02 2622 19 gibsoni gibsoni NNP cord-014516-r59usk02 2622 20 ( ( -LRB- cord-014516-r59usk02 2622 21 88.2 88.2 CD cord-014516-r59usk02 2622 22 % % NN cord-014516-r59usk02 2622 23 , , , cord-014516-r59usk02 2622 24 n n NN cord-014516-r59usk02 2622 25 = = SYM cord-014516-r59usk02 2622 26 67 67 CD cord-014516-r59usk02 2622 27 ) ) -RRB- cord-014516-r59usk02 2622 28 , , , cord-014516-r59usk02 2622 29 followed follow VBN cord-014516-r59usk02 2622 30 by by IN cord-014516-r59usk02 2622 31 Ehrlichia Ehrlichia NNP cord-014516-r59usk02 2622 32 canis canis NN cord-014516-r59usk02 2622 33 ( ( -LRB- cord-014516-r59usk02 2622 34 6.6 6.6 CD cord-014516-r59usk02 2622 35 % % NN cord-014516-r59usk02 2622 36 , , , cord-014516-r59usk02 2622 37 n n NN cord-014516-r59usk02 2622 38 = = SYM cord-014516-r59usk02 2622 39 5)and 5)and CD cord-014516-r59usk02 2623 1 Babesia Babesia NNP cord-014516-r59usk02 2623 2 canis canis NN cord-014516-r59usk02 2623 3 ( ( -LRB- cord-014516-r59usk02 2623 4 3.9 3.9 CD cord-014516-r59usk02 2623 5 % % NN cord-014516-r59usk02 2623 6 , , , cord-014516-r59usk02 2623 7 n n NN cord-014516-r59usk02 2623 8 = = SYM cord-014516-r59usk02 2623 9 3 3 CD cord-014516-r59usk02 2623 10 ) ) -RRB- cord-014516-r59usk02 2623 11 . . . cord-014516-r59usk02 2624 1 Taken take VBN cord-014516-r59usk02 2624 2 together together RB cord-014516-r59usk02 2624 3 , , , cord-014516-r59usk02 2624 4 tumors tumor NNS cord-014516-r59usk02 2624 5 , , , cord-014516-r59usk02 2624 6 infectious infectious JJ cord-014516-r59usk02 2624 7 diseases disease NNS cord-014516-r59usk02 2624 8 , , , cord-014516-r59usk02 2624 9 and and CC cord-014516-r59usk02 2624 10 renal renal JJ cord-014516-r59usk02 2624 11 failure failure NN cord-014516-r59usk02 2624 12 are be VBP cord-014516-r59usk02 2624 13 the the DT cord-014516-r59usk02 2624 14 most most RBS cord-014516-r59usk02 2624 15 frequently frequently RB cord-014516-r59usk02 2624 16 causes cause NNS cord-014516-r59usk02 2624 17 of of IN cord-014516-r59usk02 2624 18 canine canine JJ cord-014516-r59usk02 2624 19 anemia anemia NN cord-014516-r59usk02 2624 20 in in IN cord-014516-r59usk02 2624 21 Taiwan Taiwan NNP cord-014516-r59usk02 2624 22 , , , cord-014516-r59usk02 2624 23 furthermore furthermore RB cord-014516-r59usk02 2624 24 , , , cord-014516-r59usk02 2624 25 B. B. NNP cord-014516-r59usk02 2624 26 gibsoni gibsoni NNP cord-014516-r59usk02 2624 27 appeared appear VBD cord-014516-r59usk02 2624 28 to to TO cord-014516-r59usk02 2624 29 be be VB cord-014516-r59usk02 2624 30 the the DT cord-014516-r59usk02 2624 31 most most RBS cord-014516-r59usk02 2624 32 important important JJ cord-014516-r59usk02 2624 33 infectious infectious JJ cord-014516-r59usk02 2624 34 pathogen pathogen NN cord-014516-r59usk02 2624 35 causing cause VBG cord-014516-r59usk02 2624 36 severe severe JJ cord-014516-r59usk02 2624 37 anemia anemia NN cord-014516-r59usk02 2624 38 which which WDT cord-014516-r59usk02 2624 39 may may MD cord-014516-r59usk02 2624 40 be be VB cord-014516-r59usk02 2624 41 associated associate VBN cord-014516-r59usk02 2624 42 with with IN cord-014516-r59usk02 2624 43 the the DT cord-014516-r59usk02 2624 44 climate climate NN cord-014516-r59usk02 2624 45 in in IN cord-014516-r59usk02 2624 46 this this DT cord-014516-r59usk02 2624 47 geographical geographical JJ cord-014516-r59usk02 2624 48 area area NN cord-014516-r59usk02 2624 49 . . . cord-014516-r59usk02 2625 1 No no DT cord-014516-r59usk02 2625 2 conflicts conflict NNS cord-014516-r59usk02 2625 3 of of IN cord-014516-r59usk02 2625 4 interest interest NN cord-014516-r59usk02 2625 5 reported report VBN cord-014516-r59usk02 2625 6 . . . cord-014516-r59usk02 2626 1 Bordetella Bordetella NNP cord-014516-r59usk02 2626 2 bronchiseptica bronchiseptica NNP cord-014516-r59usk02 2626 3 ( ( -LRB- cord-014516-r59usk02 2626 4 Bb Bb NNP cord-014516-r59usk02 2626 5 ) ) -RRB- cord-014516-r59usk02 2626 6 is be VBZ cord-014516-r59usk02 2626 7 one one CD cord-014516-r59usk02 2626 8 of of IN cord-014516-r59usk02 2626 9 the the DT cord-014516-r59usk02 2626 10 primary primary JJ cord-014516-r59usk02 2626 11 causative causative JJ cord-014516-r59usk02 2626 12 agents agent NNS cord-014516-r59usk02 2626 13 of of IN cord-014516-r59usk02 2626 14 canine canine JJ cord-014516-r59usk02 2626 15 infectious infectious JJ cord-014516-r59usk02 2626 16 respiratory respiratory JJ cord-014516-r59usk02 2626 17 disease disease NN cord-014516-r59usk02 2626 18 ( ( -LRB- cord-014516-r59usk02 2626 19 CIRD CIRD NNP cord-014516-r59usk02 2626 20 ) ) -RRB- cord-014516-r59usk02 2626 21 . . . cord-014516-r59usk02 2627 1 This this DT cord-014516-r59usk02 2627 2 contagious contagious JJ cord-014516-r59usk02 2627 3 disease disease NN cord-014516-r59usk02 2627 4 , , , cord-014516-r59usk02 2627 5 commonly commonly RB cord-014516-r59usk02 2627 6 seen see VBN cord-014516-r59usk02 2627 7 in in IN cord-014516-r59usk02 2627 8 young young JJ cord-014516-r59usk02 2627 9 dogs dog NNS cord-014516-r59usk02 2627 10 , , , cord-014516-r59usk02 2627 11 is be VBZ cord-014516-r59usk02 2627 12 often often RB cord-014516-r59usk02 2627 13 self self NN cord-014516-r59usk02 2627 14 - - HYPH cord-014516-r59usk02 2627 15 limiting limit VBG cord-014516-r59usk02 2627 16 , , , cord-014516-r59usk02 2627 17 although although IN cord-014516-r59usk02 2627 18 a a DT cord-014516-r59usk02 2627 19 wide wide JJ cord-014516-r59usk02 2627 20 range range NN cord-014516-r59usk02 2627 21 of of IN cord-014516-r59usk02 2627 22 respiratory respiratory JJ cord-014516-r59usk02 2627 23 signs sign NNS cord-014516-r59usk02 2627 24 can can MD cord-014516-r59usk02 2627 25 be be VB cord-014516-r59usk02 2627 26 found find VBN cord-014516-r59usk02 2627 27 , , , cord-014516-r59usk02 2627 28 from from IN cord-014516-r59usk02 2627 29 mild mild JJ cord-014516-r59usk02 2627 30 illness illness NN cord-014516-r59usk02 2627 31 to to IN cord-014516-r59usk02 2627 32 severe severe JJ cord-014516-r59usk02 2627 33 pneumonia pneumonia NN cord-014516-r59usk02 2627 34 leading lead VBG cord-014516-r59usk02 2627 35 to to IN cord-014516-r59usk02 2627 36 death death NN cord-014516-r59usk02 2627 37 . . . cord-014516-r59usk02 2628 1 Although although IN cord-014516-r59usk02 2628 2 Mycoplasma Mycoplasma NNP cord-014516-r59usk02 2628 3 cynos cynos NN cord-014516-r59usk02 2628 4 ( ( -LRB- cord-014516-r59usk02 2628 5 M. M. NNP cord-014516-r59usk02 2628 6 cynos cynos NNP cord-014516-r59usk02 2628 7 ) ) -RRB- cord-014516-r59usk02 2628 8 was be VBD cord-014516-r59usk02 2628 9 recently recently RB cord-014516-r59usk02 2628 10 identified identify VBN cord-014516-r59usk02 2628 11 as as IN cord-014516-r59usk02 2628 12 an an DT cord-014516-r59usk02 2628 13 emerging emerge VBG cord-014516-r59usk02 2628 14 and and CC cord-014516-r59usk02 2628 15 possibly possibly RB cord-014516-r59usk02 2628 16 lethal lethal JJ cord-014516-r59usk02 2628 17 pathogen pathogen NN cord-014516-r59usk02 2628 18 in in IN cord-014516-r59usk02 2628 19 CIRD CIRD NNP cord-014516-r59usk02 2628 20 1 1 CD cord-014516-r59usk02 2628 21 , , , cord-014516-r59usk02 2628 22 the the DT cord-014516-r59usk02 2628 23 role role NN cord-014516-r59usk02 2628 24 of of IN cord-014516-r59usk02 2628 25 M. M. NNP cord-014516-r59usk02 2628 26 canis canis NNP cord-014516-r59usk02 2628 27 and and CC cord-014516-r59usk02 2628 28 M. M. NNP cord-014516-r59usk02 2628 29 cynos cynos NNP cord-014516-r59usk02 2628 30 as as IN cord-014516-r59usk02 2628 31 primary primary JJ cord-014516-r59usk02 2628 32 respiratory respiratory JJ cord-014516-r59usk02 2628 33 pathogens pathogen NNS cord-014516-r59usk02 2628 34 still still RB cord-014516-r59usk02 2628 35 remains remain VBZ cord-014516-r59usk02 2628 36 unclear unclear JJ cord-014516-r59usk02 2628 37 . . . cord-014516-r59usk02 2629 1 Detection detection NN cord-014516-r59usk02 2629 2 of of IN cord-014516-r59usk02 2629 3 these these DT cord-014516-r59usk02 2629 4 bacteria bacteria NNS cord-014516-r59usk02 2629 5 is be VBZ cord-014516-r59usk02 2629 6 now now RB cord-014516-r59usk02 2629 7 improved improve VBN cord-014516-r59usk02 2629 8 by by IN cord-014516-r59usk02 2629 9 quantitative quantitative JJ cord-014516-r59usk02 2629 10 polymerase polymerase NN cord-014516-r59usk02 2629 11 chain chain NN cord-014516-r59usk02 2629 12 reaction reaction NN cord-014516-r59usk02 2629 13 ( ( -LRB- cord-014516-r59usk02 2629 14 qPCR qPCR NNP cord-014516-r59usk02 2629 15 ) ) -RRB- cord-014516-r59usk02 2629 16 . . . cord-014516-r59usk02 2630 1 In in IN cord-014516-r59usk02 2630 2 dogs dog NNS cord-014516-r59usk02 2630 3 with with IN cord-014516-r59usk02 2630 4 CIRD cird NN cord-014516-r59usk02 2630 5 due due IN cord-014516-r59usk02 2630 6 to to IN cord-014516-r59usk02 2630 7 Bb Bb NNP cord-014516-r59usk02 2630 8 , , , cord-014516-r59usk02 2630 9 the the DT cord-014516-r59usk02 2630 10 frequency frequency NN cord-014516-r59usk02 2630 11 of of IN cord-014516-r59usk02 2630 12 co co NN cord-014516-r59usk02 2630 13 - - NN cord-014516-r59usk02 2630 14 infection infection NN cord-014516-r59usk02 2630 15 with with IN cord-014516-r59usk02 2630 16 Mycoplasma Mycoplasma NNP cord-014516-r59usk02 2630 17 spp spp NNS cord-014516-r59usk02 2630 18 , , , cord-014516-r59usk02 2630 19 in in IN cord-014516-r59usk02 2630 20 par par NN cord-014516-r59usk02 2630 21 - - HYPH cord-014516-r59usk02 2630 22 ticularM. ticularm. NN cord-014516-r59usk02 2630 23 cynos cynos NN cord-014516-r59usk02 2630 24 , , , cord-014516-r59usk02 2630 25 and and CC cord-014516-r59usk02 2630 26 their -PRON- PRP$ cord-014516-r59usk02 2630 27 possible possible JJ cord-014516-r59usk02 2630 28 role role NN cord-014516-r59usk02 2630 29 in in IN cord-014516-r59usk02 2630 30 the the DT cord-014516-r59usk02 2630 31 severity severity NN cord-014516-r59usk02 2630 32 of of IN cord-014516-r59usk02 2630 33 the the DT cord-014516-r59usk02 2630 34 clinical clinical JJ cord-014516-r59usk02 2630 35 signs sign NNS cord-014516-r59usk02 2630 36 are be VBP cord-014516-r59usk02 2630 37 unknown unknown JJ cord-014516-r59usk02 2630 38 . . . cord-014516-r59usk02 2631 1 The the DT cord-014516-r59usk02 2631 2 aim aim NN cord-014516-r59usk02 2631 3 of of IN cord-014516-r59usk02 2631 4 the the DT cord-014516-r59usk02 2631 5 present present JJ cord-014516-r59usk02 2631 6 study study NN cord-014516-r59usk02 2631 7 was be VBD cord-014516-r59usk02 2631 8 to to TO cord-014516-r59usk02 2631 9 investigate investigate VB cord-014516-r59usk02 2631 10 the the DT cord-014516-r59usk02 2631 11 presence presence NN cord-014516-r59usk02 2631 12 of of IN cord-014516-r59usk02 2631 13 M. M. NNP cord-014516-r59usk02 2631 14 canis canis NNP cord-014516-r59usk02 2631 15 and and CC cord-014516-r59usk02 2631 16 M. M. NNP cord-014516-r59usk02 2631 17 cynos cynos NN cord-014516-r59usk02 2631 18 in in IN cord-014516-r59usk02 2631 19 a a DT cord-014516-r59usk02 2631 20 population population NN cord-014516-r59usk02 2631 21 of of IN cord-014516-r59usk02 2631 22 dog dog NN cord-014516-r59usk02 2631 23 infected infect VBN cord-014516-r59usk02 2631 24 with with IN cord-014516-r59usk02 2631 25 Bb Bb NNP cord-014516-r59usk02 2631 26 , , , cord-014516-r59usk02 2631 27 compared compare VBN cord-014516-r59usk02 2631 28 with with IN cord-014516-r59usk02 2631 29 2 2 CD cord-014516-r59usk02 2631 30 other other JJ cord-014516-r59usk02 2631 31 populations population NNS cord-014516-r59usk02 2631 32 : : : cord-014516-r59usk02 2631 33 healthy healthy JJ cord-014516-r59usk02 2631 34 dogs dog NNS cord-014516-r59usk02 2631 35 and and CC cord-014516-r59usk02 2631 36 dogs dog NNS cord-014516-r59usk02 2631 37 with with IN cord-014516-r59usk02 2631 38 bacterial bacterial JJ cord-014516-r59usk02 2631 39 bronchopneumonia bronchopneumonia NN cord-014516-r59usk02 2631 40 where where WRB cord-014516-r59usk02 2631 41 Bb Bb NNP cord-014516-r59usk02 2631 42 was be VBD cord-014516-r59usk02 2631 43 not not RB cord-014516-r59usk02 2631 44 involved involve VBN cord-014516-r59usk02 2631 45 ( ( -LRB- cord-014516-r59usk02 2631 46 BBP BBP NNP cord-014516-r59usk02 2631 47 ) ) -RRB- cord-014516-r59usk02 2631 48 . . . cord-014516-r59usk02 2632 1 Therefore therefore RB cord-014516-r59usk02 2632 2 , , , cord-014516-r59usk02 2632 3 Bb Bb NNP cord-014516-r59usk02 2632 4 , , , cord-014516-r59usk02 2632 5 M. M. NNP cord-014516-r59usk02 2632 6 canis canis NNP cord-014516-r59usk02 2632 7 and and CC cord-014516-r59usk02 2632 8 M. M. NNP cord-014516-r59usk02 2632 9 cynos cynos NNP cord-014516-r59usk02 2632 10 were be VBD cord-014516-r59usk02 2632 11 detected detect VBN cord-014516-r59usk02 2632 12 by by IN cord-014516-r59usk02 2632 13 qPCR qPCR NNP cord-014516-r59usk02 2632 14 in in IN cord-014516-r59usk02 2632 15 the the DT cord-014516-r59usk02 2632 16 bronchoalveolar bronchoalveolar NNP cord-014516-r59usk02 2632 17 lavage lavage NN cord-014516-r59usk02 2632 18 fluid fluid NN cord-014516-r59usk02 2632 19 ( ( -LRB- cord-014516-r59usk02 2632 20 BALF BALF NNP cord-014516-r59usk02 2632 21 ) ) -RRB- cord-014516-r59usk02 2632 22 sample sample NN cord-014516-r59usk02 2632 23 in in IN cord-014516-r59usk02 2632 24 16 16 CD cord-014516-r59usk02 2632 25 dogs dog NNS cord-014516-r59usk02 2632 26 with with IN cord-014516-r59usk02 2632 27 Bb Bb NNP cord-014516-r59usk02 2632 28 ( ( -LRB- cord-014516-r59usk02 2632 29 mean mean VB cord-014516-r59usk02 2632 30 age age NN cord-014516-r59usk02 2632 31 = = SYM cord-014516-r59usk02 2632 32 0.9 0.9 CD cord-014516-r59usk02 2632 33 y y NN cord-014516-r59usk02 2632 34 , , , cord-014516-r59usk02 2632 35 mean mean VB cord-014516-r59usk02 2632 36 BW BW NNP cord-014516-r59usk02 2632 37 = = SYM cord-014516-r59usk02 2632 38 8.8 8.8 CD cord-014516-r59usk02 2632 39 kg kg NNS cord-014516-r59usk02 2632 40 ) ) -RRB- cord-014516-r59usk02 2632 41 , , , cord-014516-r59usk02 2632 42 10 10 CD cord-014516-r59usk02 2632 43 dogs dog NNS cord-014516-r59usk02 2632 44 with with IN cord-014516-r59usk02 2632 45 BBP BBP NNP cord-014516-r59usk02 2632 46 ( ( -LRB- cord-014516-r59usk02 2632 47 3.9 3.9 CD cord-014516-r59usk02 2632 48 y y NN cord-014516-r59usk02 2632 49 , , , cord-014516-r59usk02 2632 50 15.0 15.0 CD cord-014516-r59usk02 2632 51 kg kg NNP cord-014516-r59usk02 2632 52 ) ) -RRB- cord-014516-r59usk02 2632 53 , , , cord-014516-r59usk02 2632 54 and and CC cord-014516-r59usk02 2632 55 10 10 CD cord-014516-r59usk02 2632 56 healthy healthy JJ cord-014516-r59usk02 2632 57 dogs dog NNS cord-014516-r59usk02 2632 58 ( ( -LRB- cord-014516-r59usk02 2632 59 6.1y 6.1y CD cord-014516-r59usk02 2632 60 , , , cord-014516-r59usk02 2632 61 20.2 20.2 CD cord-014516-r59usk02 2632 62 kg kg NNS cord-014516-r59usk02 2632 63 ) ) -RRB- cord-014516-r59usk02 2632 64 . . . cord-014516-r59usk02 2633 1 Bordetellosis Bordetellosis NNP cord-014516-r59usk02 2633 2 was be VBD cord-014516-r59usk02 2633 3 diagnosed diagnose VBN cord-014516-r59usk02 2633 4 based base VBN cord-014516-r59usk02 2633 5 on on IN cord-014516-r59usk02 2633 6 clinical clinical JJ cord-014516-r59usk02 2633 7 findings finding NNS cord-014516-r59usk02 2633 8 together together RB cord-014516-r59usk02 2633 9 with with IN cord-014516-r59usk02 2633 10 demonstration demonstration NN cord-014516-r59usk02 2633 11 of of IN cord-014516-r59usk02 2633 12 pleiomorphic pleiomorphic NNP cord-014516-r59usk02 2633 13 cocci cocci NNP cord-014516-r59usk02 2633 14 / / SYM cord-014516-r59usk02 2633 15 coccobacilli coccobacilli NNP cord-014516-r59usk02 2633 16 adhering adhere VBG cord-014516-r59usk02 2633 17 to to IN cord-014516-r59usk02 2633 18 the the DT cord-014516-r59usk02 2633 19 cilia cilia NN cord-014516-r59usk02 2633 20 of of IN cord-014516-r59usk02 2633 21 the the DT cord-014516-r59usk02 2633 22 epithelial epithelial JJ cord-014516-r59usk02 2633 23 cells cell NNS cord-014516-r59usk02 2633 24 on on IN cord-014516-r59usk02 2633 25 cytospin cytospin JJ cord-014516-r59usk02 2633 26 BALF BALF NNP cord-014516-r59usk02 2633 27 preparations preparation NNS cord-014516-r59usk02 2633 28 , , , cord-014516-r59usk02 2633 29 and and CC cord-014516-r59usk02 2633 30 positive positive JJ cord-014516-r59usk02 2633 31 qPCR qpcr NN cord-014516-r59usk02 2633 32 on on IN cord-014516-r59usk02 2633 33 BALF BALF NNP cord-014516-r59usk02 2633 34 . . . cord-014516-r59usk02 2634 1 A a DT cord-014516-r59usk02 2634 2 clinical clinical JJ cord-014516-r59usk02 2634 3 severity severity NN cord-014516-r59usk02 2634 4 index index NN cord-014516-r59usk02 2634 5 ( ( -LRB- cord-014516-r59usk02 2634 6 CSI CSI NNP cord-014516-r59usk02 2634 7 0 0 CD cord-014516-r59usk02 2634 8 to to IN cord-014516-r59usk02 2634 9 12 12 CD cord-014516-r59usk02 2634 10 ) ) -RRB- cord-014516-r59usk02 2634 11 was be VBD cord-014516-r59usk02 2634 12 assigned assign VBN cord-014516-r59usk02 2634 13 based base VBN cord-014516-r59usk02 2634 14 on on IN cord-014516-r59usk02 2634 15 clinical clinical JJ cord-014516-r59usk02 2634 16 signs sign NNS cord-014516-r59usk02 2634 17 ( ( -LRB- cord-014516-r59usk02 2634 18 cough cough NN cord-014516-r59usk02 2634 19 0 0 CD cord-014516-r59usk02 2634 20 - - SYM cord-014516-r59usk02 2634 21 2 2 CD cord-014516-r59usk02 2634 22 , , , cord-014516-r59usk02 2634 23 dyspnea dyspnea NN cord-014516-r59usk02 2634 24 0 0 CD cord-014516-r59usk02 2634 25 - - SYM cord-014516-r59usk02 2634 26 2 2 CD cord-014516-r59usk02 2634 27 , , , cord-014516-r59usk02 2634 28 lethargy lethargy NN cord-014516-r59usk02 2634 29 0 0 CD cord-014516-r59usk02 2634 30 - - SYM cord-014516-r59usk02 2634 31 1 1 CD cord-014516-r59usk02 2634 32 , , , cord-014516-r59usk02 2634 33 fever fever NN cord-014516-r59usk02 2634 34 0 0 CD cord-014516-r59usk02 2634 35 - - SYM cord-014516-r59usk02 2634 36 1 1 CD cord-014516-r59usk02 2634 37 ) ) -RRB- cord-014516-r59usk02 2634 38 , , , cord-014516-r59usk02 2634 39 thoracic thoracic JJ cord-014516-r59usk02 2634 40 radiographic radiographic JJ cord-014516-r59usk02 2634 41 pattern pattern NN cord-014516-r59usk02 2634 42 ( ( -LRB- cord-014516-r59usk02 2634 43 0 0 CD cord-014516-r59usk02 2634 44 - - SYM cord-014516-r59usk02 2634 45 3 3 CD cord-014516-r59usk02 2634 46 ) ) -RRB- cord-014516-r59usk02 2634 47 , , , cord-014516-r59usk02 2634 48 and and CC cord-014516-r59usk02 2634 49 BALF BALF NNP cord-014516-r59usk02 2634 50 score score NN cord-014516-r59usk02 2634 51 ( ( -LRB- cord-014516-r59usk02 2634 52 0 0 CD cord-014516-r59usk02 2634 53 - - SYM cord-014516-r59usk02 2634 54 3 3 CD cord-014516-r59usk02 2634 55 ) ) -RRB- cord-014516-r59usk02 2634 56 . . . cord-014516-r59usk02 2635 1 BBP BBP NNP cord-014516-r59usk02 2635 2 was be VBD cord-014516-r59usk02 2635 3 diagnosed diagnose VBN cord-014516-r59usk02 2635 4 based base VBN cord-014516-r59usk02 2635 5 on on IN cord-014516-r59usk02 2635 6 clinical clinical JJ cord-014516-r59usk02 2635 7 findings finding NNS cord-014516-r59usk02 2635 8 , , , cord-014516-r59usk02 2635 9 BALF BALF NNP cord-014516-r59usk02 2635 10 cytology cytology NN cord-014516-r59usk02 2635 11 and and CC cord-014516-r59usk02 2635 12 culture culture NN cord-014516-r59usk02 2635 13 . . . cord-014516-r59usk02 2636 1 M. M. NNP cord-014516-r59usk02 2636 2 canis canis NNP cord-014516-r59usk02 2636 3 was be VBD cord-014516-r59usk02 2636 4 indifferently indifferently RB cord-014516-r59usk02 2636 5 detected detect VBN cord-014516-r59usk02 2636 6 in in IN cord-014516-r59usk02 2636 7 healthy healthy JJ cord-014516-r59usk02 2636 8 ( ( -LRB- cord-014516-r59usk02 2636 9 5/10 5/10 CD cord-014516-r59usk02 2636 10 , , , cord-014516-r59usk02 2636 11 50 50 CD cord-014516-r59usk02 2636 12 % % NN cord-014516-r59usk02 2636 13 ) ) -RRB- cord-014516-r59usk02 2636 14 , , , cord-014516-r59usk02 2636 15 BBP BBP NNP cord-014516-r59usk02 2636 16 ( ( -LRB- cord-014516-r59usk02 2636 17 4/10 4/10 CD cord-014516-r59usk02 2636 18 , , , cord-014516-r59usk02 2636 19 40 40 CD cord-014516-r59usk02 2636 20 % % NN cord-014516-r59usk02 2636 21 ) ) -RRB- cord-014516-r59usk02 2636 22 and and CC cord-014516-r59usk02 2636 23 Bb Bb NNP cord-014516-r59usk02 2636 24 dogs dog NNS cord-014516-r59usk02 2636 25 ( ( -LRB- cord-014516-r59usk02 2636 26 3/16 3/16 CD cord-014516-r59usk02 2636 27 , , , cord-014516-r59usk02 2636 28 19 19 CD cord-014516-r59usk02 2636 29 % % NN cord-014516-r59usk02 2636 30 ) ) -RRB- cord-014516-r59usk02 2636 31 while while IN cord-014516-r59usk02 2636 32 M. M. NNP cord-014516-r59usk02 2636 33 cynos cynos NNP cord-014516-r59usk02 2636 34 tended tend VBD cord-014516-r59usk02 2636 35 to to TO cord-014516-r59usk02 2636 36 be be VB cord-014516-r59usk02 2636 37 more more RBR cord-014516-r59usk02 2636 38 frequently frequently RB cord-014516-r59usk02 2636 39 detected detect VBN cord-014516-r59usk02 2636 40 in in IN cord-014516-r59usk02 2636 41 Bb Bb NNP cord-014516-r59usk02 2636 42 group group NN cord-014516-r59usk02 2636 43 ( ( -LRB- cord-014516-r59usk02 2636 44 8/16 8/16 CD cord-014516-r59usk02 2636 45 , , , cord-014516-r59usk02 2636 46 50 50 CD cord-014516-r59usk02 2636 47 % % NN cord-014516-r59usk02 2636 48 ) ) -RRB- cord-014516-r59usk02 2636 49 than than IN cord-014516-r59usk02 2636 50 in in IN cord-014516-r59usk02 2636 51 healthy healthy JJ cord-014516-r59usk02 2636 52 ( ( -LRB- cord-014516-r59usk02 2636 53 2/10 2/10 CD cord-014516-r59usk02 2636 54 , , , cord-014516-r59usk02 2636 55 20 20 CD cord-014516-r59usk02 2636 56 % % NN cord-014516-r59usk02 2636 57 ) ) -RRB- cord-014516-r59usk02 2636 58 and and CC cord-014516-r59usk02 2636 59 BBP BBP NNP cord-014516-r59usk02 2636 60 dogs dog NNS cord-014516-r59usk02 2636 61 ( ( -LRB- cord-014516-r59usk02 2636 62 1/10 1/10 CD cord-014516-r59usk02 2636 63 , , , cord-014516-r59usk02 2636 64 10 10 CD cord-014516-r59usk02 2636 65 % % NN cord-014516-r59usk02 2636 66 ) ) -RRB- cord-014516-r59usk02 2636 67 ( ( -LRB- cord-014516-r59usk02 2636 68 Khi² khi² JJ cord-014516-r59usk02 2636 69 test test NN cord-014516-r59usk02 2636 70 , , , cord-014516-r59usk02 2636 71 p p NN cord-014516-r59usk02 2636 72 = = SYM cord-014516-r59usk02 2636 73 0,068 0,068 CD cord-014516-r59usk02 2636 74 ) ) -RRB- cord-014516-r59usk02 2636 75 . . . cord-014516-r59usk02 2637 1 In in IN cord-014516-r59usk02 2637 2 Bb Bb NNP cord-014516-r59usk02 2637 3 dogs dog NNS cord-014516-r59usk02 2637 4 , , , cord-014516-r59usk02 2637 5 no no DT cord-014516-r59usk02 2637 6 correlation correlation NN cord-014516-r59usk02 2637 7 could could MD cord-014516-r59usk02 2637 8 be be VB cord-014516-r59usk02 2637 9 detected detect VBN cord-014516-r59usk02 2637 10 between between IN cord-014516-r59usk02 2637 11 CSI CSI NNP cord-014516-r59usk02 2637 12 and and CC cord-014516-r59usk02 2637 13 presence presence NN cord-014516-r59usk02 2637 14 of of IN cord-014516-r59usk02 2637 15 M. M. NNP cord-014516-r59usk02 2637 16 cynos cynos NNP cord-014516-r59usk02 2637 17 ( ( -LRB- cord-014516-r59usk02 2637 18 Khi² khi² JJ cord-014516-r59usk02 2637 19 test test NN cord-014516-r59usk02 2637 20 p p NN cord-014516-r59usk02 2637 21 = = SYM cord-014516-r59usk02 2637 22 0,26 0,26 CD cord-014516-r59usk02 2637 23 ) ) -RRB- cord-014516-r59usk02 2637 24 . . . cord-014516-r59usk02 2638 1 In in IN cord-014516-r59usk02 2638 2 conclusion conclusion NN cord-014516-r59usk02 2638 3 , , , cord-014516-r59usk02 2638 4 the the DT cord-014516-r59usk02 2638 5 present present JJ cord-014516-r59usk02 2638 6 data datum NNS cord-014516-r59usk02 2638 7 suggest suggest VBP cord-014516-r59usk02 2638 8 that that IN cord-014516-r59usk02 2638 9 , , , cord-014516-r59usk02 2638 10 in in IN cord-014516-r59usk02 2638 11 CIRD CIRD NNP cord-014516-r59usk02 2638 12 , , , cord-014516-r59usk02 2638 13 coinfection coinfection NN cord-014516-r59usk02 2638 14 with with IN cord-014516-r59usk02 2638 15 Bb Bb NNP cord-014516-r59usk02 2638 16 and and CC cord-014516-r59usk02 2638 17 M. M. NNP cord-014516-r59usk02 2638 18 cynos cynos NNP cord-014516-r59usk02 2638 19 is be VBZ cord-014516-r59usk02 2638 20 frequent frequent JJ cord-014516-r59usk02 2638 21 , , , cord-014516-r59usk02 2638 22 but but CC cord-014516-r59usk02 2638 23 is be VBZ cord-014516-r59usk02 2638 24 not not RB cord-014516-r59usk02 2638 25 correlated correlate VBN cord-014516-r59usk02 2638 26 with with IN cord-014516-r59usk02 2638 27 clinical clinical JJ cord-014516-r59usk02 2638 28 disease disease NN cord-014516-r59usk02 2638 29 severity severity NN cord-014516-r59usk02 2638 30 . . . cord-014516-r59usk02 2639 1 Further further JJ cord-014516-r59usk02 2639 2 studies study NNS cord-014516-r59usk02 2639 3 are be VBP cord-014516-r59usk02 2639 4 required require VBN cord-014516-r59usk02 2639 5 to to TO cord-014516-r59usk02 2639 6 investigate investigate VB cord-014516-r59usk02 2639 7 whether whether IN cord-014516-r59usk02 2639 8 coinfection coinfection NN cord-014516-r59usk02 2639 9 of of IN cord-014516-r59usk02 2639 10 Bb Bb NNP cord-014516-r59usk02 2639 11 and and CC cord-014516-r59usk02 2639 12 M. M. NNP cord-014516-r59usk02 2639 13 cynos cynos NNP cord-014516-r59usk02 2639 14 deserves deserve VBZ cord-014516-r59usk02 2639 15 specific specific JJ cord-014516-r59usk02 2639 16 therapeutic therapeutic JJ cord-014516-r59usk02 2639 17 considerations consideration NNS cord-014516-r59usk02 2639 18 . . . cord-014516-r59usk02 2640 1 No no DT cord-014516-r59usk02 2640 2 conflicts conflict NNS cord-014516-r59usk02 2640 3 of of IN cord-014516-r59usk02 2640 4 interest interest NN cord-014516-r59usk02 2640 5 reported report VBN cord-014516-r59usk02 2640 6 . . . cord-014516-r59usk02 2641 1 Canine canine JJ cord-014516-r59usk02 2641 2 idiopathic idiopathic JJ cord-014516-r59usk02 2641 3 eosinophilic eosinophilic JJ cord-014516-r59usk02 2641 4 bronchopneumopathy bronchopneumopathy NN cord-014516-r59usk02 2641 5 ( ( -LRB- cord-014516-r59usk02 2641 6 EBP EBP NNP cord-014516-r59usk02 2641 7 ) ) -RRB- cord-014516-r59usk02 2641 8 is be VBZ cord-014516-r59usk02 2641 9 a a DT cord-014516-r59usk02 2641 10 disease disease NN cord-014516-r59usk02 2641 11 characterized characterize VBN cord-014516-r59usk02 2641 12 by by IN cord-014516-r59usk02 2641 13 eosinophilic eosinophilic JJ cord-014516-r59usk02 2641 14 infiltration infiltration NN cord-014516-r59usk02 2641 15 of of IN cord-014516-r59usk02 2641 16 the the DT cord-014516-r59usk02 2641 17 lung lung NN cord-014516-r59usk02 2641 18 and and CC cord-014516-r59usk02 2641 19 bronchial bronchial JJ cord-014516-r59usk02 2641 20 mucosa mucosa NN cord-014516-r59usk02 2641 21 in in IN cord-014516-r59usk02 2641 22 young young JJ cord-014516-r59usk02 2641 23 adults adult NNS cord-014516-r59usk02 2641 24 . . . cord-014516-r59usk02 2642 1 Aetiology Aetiology NNP cord-014516-r59usk02 2642 2 remains remain VBZ cord-014516-r59usk02 2642 3 unclear unclear JJ cord-014516-r59usk02 2642 4 although although IN cord-014516-r59usk02 2642 5 immunologic immunologic JJ cord-014516-r59usk02 2642 6 hypersensitivity hypersensitivity NN cord-014516-r59usk02 2642 7 is be VBZ cord-014516-r59usk02 2642 8 clearly clearly RB cord-014516-r59usk02 2642 9 suspected suspect VBN cord-014516-r59usk02 2642 10 , , , cord-014516-r59usk02 2642 11 while while IN cord-014516-r59usk02 2642 12 inciting incite VBG cord-014516-r59usk02 2642 13 antigens antigen NNS cord-014516-r59usk02 2642 14 are be VBP cord-014516-r59usk02 2642 15 generally generally RB cord-014516-r59usk02 2642 16 unidentified unidentified JJ cord-014516-r59usk02 2642 17 . . . cord-014516-r59usk02 2643 1 In in IN cord-014516-r59usk02 2643 2 humans human NNS cord-014516-r59usk02 2643 3 as as IN cord-014516-r59usk02 2643 4 in in IN cord-014516-r59usk02 2643 5 cats cat NNS cord-014516-r59usk02 2643 6 , , , cord-014516-r59usk02 2643 7 infections infection NNS cord-014516-r59usk02 2643 8 with with IN cord-014516-r59usk02 2643 9 Mycoplasma mycoplasma NN cord-014516-r59usk02 2643 10 spp spp NNS cord-014516-r59usk02 2643 11 . . . cord-014516-r59usk02 2644 1 have have VBP cord-014516-r59usk02 2644 2 been be VBN cord-014516-r59usk02 2644 3 discussed discuss VBN cord-014516-r59usk02 2644 4 as as IN cord-014516-r59usk02 2644 5 potential potential JJ cord-014516-r59usk02 2644 6 triggers trigger NNS cord-014516-r59usk02 2644 7 in in IN cord-014516-r59usk02 2644 8 inflammatory inflammatory JJ cord-014516-r59usk02 2644 9 bronchial bronchial JJ cord-014516-r59usk02 2644 10 disease disease NN cord-014516-r59usk02 2644 11 1,2 1,2 CD cord-014516-r59usk02 2644 12 . . . cord-014516-r59usk02 2645 1 Bordetella Bordetella NNP cord-014516-r59usk02 2645 2 bronchiseptica bronchiseptica NNP cord-014516-r59usk02 2645 3 ( ( -LRB- cord-014516-r59usk02 2645 4 Bb Bb NNP cord-014516-r59usk02 2645 5 ) ) -RRB- cord-014516-r59usk02 2645 6 is be VBZ cord-014516-r59usk02 2645 7 a a DT cord-014516-r59usk02 2645 8 recognized recognize VBN cord-014516-r59usk02 2645 9 pathogen pathogen NN cord-014516-r59usk02 2645 10 agent agent NN cord-014516-r59usk02 2645 11 of of IN cord-014516-r59usk02 2645 12 canine canine JJ cord-014516-r59usk02 2645 13 infectious infectious JJ cord-014516-r59usk02 2645 14 tracheobronchitis tracheobronchitis NN cord-014516-r59usk02 2645 15 . . . cord-014516-r59usk02 2646 1 Detection detection NN cord-014516-r59usk02 2646 2 of of IN cord-014516-r59usk02 2646 3 Bb Bb NNP cord-014516-r59usk02 2646 4 and and CC cord-014516-r59usk02 2646 5 Mycoplasma Mycoplasma NNP cord-014516-r59usk02 2646 6 spp spp NNS cord-014516-r59usk02 2646 7 , , , cord-014516-r59usk02 2647 1 especially especially RB cord-014516-r59usk02 2647 2 Mycoplasma Mycoplasma NNP cord-014516-r59usk02 2647 3 cynos cynos NN cord-014516-r59usk02 2647 4 ( ( -LRB- cord-014516-r59usk02 2647 5 M. M. NNP cord-014516-r59usk02 2647 6 cynos cynos NNP cord-014516-r59usk02 2647 7 ) ) -RRB- cord-014516-r59usk02 2647 8 , , , cord-014516-r59usk02 2647 9 and and CC cord-014516-r59usk02 2647 10 their -PRON- PRP$ cord-014516-r59usk02 2647 11 potential potential JJ cord-014516-r59usk02 2647 12 role role NN cord-014516-r59usk02 2647 13 of of IN cord-014516-r59usk02 2647 14 in in IN cord-014516-r59usk02 2647 15 canine canine JJ cord-014516-r59usk02 2647 16 inflammatory inflammatory JJ cord-014516-r59usk02 2647 17 bronchitis bronchitis NN cord-014516-r59usk02 2647 18 , , , cord-014516-r59usk02 2647 19 have have VBP cord-014516-r59usk02 2647 20 not not RB cord-014516-r59usk02 2647 21 been be VBN cord-014516-r59usk02 2647 22 investigated investigate VBN cord-014516-r59usk02 2647 23 . . . cord-014516-r59usk02 2648 1 The the DT cord-014516-r59usk02 2648 2 aim aim NN cord-014516-r59usk02 2648 3 of of IN cord-014516-r59usk02 2648 4 the the DT cord-014516-r59usk02 2648 5 present present JJ cord-014516-r59usk02 2648 6 study study NN cord-014516-r59usk02 2648 7 was be VBD cord-014516-r59usk02 2648 8 to to TO cord-014516-r59usk02 2648 9 investigate investigate VB cord-014516-r59usk02 2648 10 the the DT cord-014516-r59usk02 2648 11 frequency frequency NN cord-014516-r59usk02 2648 12 of of IN cord-014516-r59usk02 2648 13 Bb Bb NNP cord-014516-r59usk02 2648 14 , , , cord-014516-r59usk02 2648 15 Mycoplasma Mycoplasma NNP cord-014516-r59usk02 2648 16 canis canis NN cord-014516-r59usk02 2648 17 ( ( -LRB- cord-014516-r59usk02 2648 18 M. M. NNP cord-014516-r59usk02 2648 19 canis canis NNP cord-014516-r59usk02 2648 20 ) ) -RRB- cord-014516-r59usk02 2648 21 and and CC cord-014516-r59usk02 2648 22 M. M. NNP cord-014516-r59usk02 2648 23 cynos cynos NN cord-014516-r59usk02 2648 24 in in IN cord-014516-r59usk02 2648 25 canine canine JJ cord-014516-r59usk02 2648 26 EBP ebp NN cord-014516-r59usk02 2648 27 . . . cord-014516-r59usk02 2649 1 Therefore therefore RB cord-014516-r59usk02 2649 2 , , , cord-014516-r59usk02 2649 3 presence presence NN cord-014516-r59usk02 2649 4 of of IN cord-014516-r59usk02 2649 5 Bb Bb NNP cord-014516-r59usk02 2649 6 , , , cord-014516-r59usk02 2649 7 M. M. NNP cord-014516-r59usk02 2649 8 canis canis NNP cord-014516-r59usk02 2649 9 and and CC cord-014516-r59usk02 2649 10 M. M. NNP cord-014516-r59usk02 2649 11 cynos cynos NNP cord-014516-r59usk02 2649 12 were be VBD cord-014516-r59usk02 2649 13 retrospectively retrospectively RB cord-014516-r59usk02 2649 14 assessed assess VBN cord-014516-r59usk02 2649 15 by by IN cord-014516-r59usk02 2649 16 quantitative quantitative JJ cord-014516-r59usk02 2649 17 polymerase polymerase NN cord-014516-r59usk02 2649 18 chain chain NN cord-014516-r59usk02 2649 19 reaction reaction NN cord-014516-r59usk02 2649 20 ( ( -LRB- cord-014516-r59usk02 2649 21 qPCR qPCR NNP cord-014516-r59usk02 2649 22 ) ) -RRB- cord-014516-r59usk02 2649 23 in in IN cord-014516-r59usk02 2649 24 bronchoalveolar bronchoalveolar NNP cord-014516-r59usk02 2649 25 lavage lavage NN cord-014516-r59usk02 2649 26 fluid fluid NN cord-014516-r59usk02 2649 27 ( ( -LRB- cord-014516-r59usk02 2649 28 BALF BALF NNP cord-014516-r59usk02 2649 29 ) ) -RRB- cord-014516-r59usk02 2649 30 samples sample NNS cord-014516-r59usk02 2649 31 from from IN cord-014516-r59usk02 2649 32 18 18 CD cord-014516-r59usk02 2649 33 dogs dog NNS cord-014516-r59usk02 2649 34 with with IN cord-014516-r59usk02 2649 35 EBP ebp NN cord-014516-r59usk02 2649 36 ( ( -LRB- cord-014516-r59usk02 2649 37 mean mean JJ cord-014516-r59usk02 2649 38 age age NN cord-014516-r59usk02 2649 39 = = SYM cord-014516-r59usk02 2649 40 4.5 4.5 CD cord-014516-r59usk02 2649 41 y y NN cord-014516-r59usk02 2649 42 , , , cord-014516-r59usk02 2649 43 mean mean VB cord-014516-r59usk02 2649 44 body body NN cord-014516-r59usk02 2649 45 weight weight NN cord-014516-r59usk02 2649 46 = = SYM cord-014516-r59usk02 2649 47 21.1 21.1 CD cord-014516-r59usk02 2649 48 kg kg NNS cord-014516-r59usk02 2649 49 ) ) -RRB- cord-014516-r59usk02 2649 50 as as RB cord-014516-r59usk02 2649 51 well well RB cord-014516-r59usk02 2649 52 as as IN cord-014516-r59usk02 2649 53 in in IN cord-014516-r59usk02 2649 54 8 8 CD cord-014516-r59usk02 2649 55 dogs dog NNS cord-014516-r59usk02 2649 56 with with IN cord-014516-r59usk02 2649 57 aspecific aspecific NN cord-014516-r59usk02 2649 58 chronic chronic JJ cord-014516-r59usk02 2649 59 bronchitis bronchitis NN cord-014516-r59usk02 2649 60 ( ( -LRB- cord-014516-r59usk02 2649 61 7.3 7.3 CD cord-014516-r59usk02 2649 62 y y NNP cord-014516-r59usk02 2649 63 , , , cord-014516-r59usk02 2649 64 22.3 22.3 CD cord-014516-r59usk02 2649 65 kg kg NNP cord-014516-r59usk02 2649 66 ) ) -RRB- cord-014516-r59usk02 2649 67 . . . cord-014516-r59usk02 2650 1 Based base VBN cord-014516-r59usk02 2650 2 on on IN cord-014516-r59usk02 2650 3 clinical clinical JJ cord-014516-r59usk02 2650 4 signs sign NNS cord-014516-r59usk02 2650 5 , , , cord-014516-r59usk02 2650 6 a a DT cord-014516-r59usk02 2650 7 clinical clinical JJ cord-014516-r59usk02 2650 8 severity severity NN cord-014516-r59usk02 2650 9 score score NN cord-014516-r59usk02 2650 10 ( ( -LRB- cord-014516-r59usk02 2650 11 CSS css NN cord-014516-r59usk02 2650 12 , , , cord-014516-r59usk02 2650 13 0 0 CD cord-014516-r59usk02 2650 14 - - SYM cord-014516-r59usk02 2650 15 5 5 CD cord-014516-r59usk02 2650 16 ) ) -RRB- cord-014516-r59usk02 2650 17 was be VBD cord-014516-r59usk02 2650 18 assigned assign VBN cord-014516-r59usk02 2650 19 each each DT cord-014516-r59usk02 2650 20 EBP ebp NN cord-014516-r59usk02 2650 21 dog dog NN cord-014516-r59usk02 2650 22 . . . cord-014516-r59usk02 2651 1 Although although IN cord-014516-r59usk02 2651 2 all all DT cord-014516-r59usk02 2651 3 BALF BALF NNP cord-014516-r59usk02 2651 4 culture culture NN cord-014516-r59usk02 2651 5 and and CC cord-014516-r59usk02 2651 6 cytology cytology NN cord-014516-r59usk02 2651 7 were be VBD cord-014516-r59usk02 2651 8 negative negative JJ cord-014516-r59usk02 2651 9 for for IN cord-014516-r59usk02 2651 10 this this DT cord-014516-r59usk02 2651 11 bacteria bacteria NNS cord-014516-r59usk02 2651 12 , , , cord-014516-r59usk02 2651 13 Bb Bb NNP cord-014516-r59usk02 2651 14 was be VBD cord-014516-r59usk02 2651 15 more more RBR cord-014516-r59usk02 2651 16 frequently frequently RB cord-014516-r59usk02 2651 17 detected detect VBN cord-014516-r59usk02 2651 18 by by IN cord-014516-r59usk02 2651 19 qPCR qPCR NNP cord-014516-r59usk02 2651 20 in in IN cord-014516-r59usk02 2651 21 EBP ebp NN cord-014516-r59usk02 2651 22 dogs dog NNS cord-014516-r59usk02 2651 23 ( ( -LRB- cord-014516-r59usk02 2651 24 5/18 5/18 CD cord-014516-r59usk02 2651 25 , , , cord-014516-r59usk02 2651 26 28 28 CD cord-014516-r59usk02 2651 27 % % NN cord-014516-r59usk02 2651 28 ) ) -RRB- cord-014516-r59usk02 2651 29 than than IN cord-014516-r59usk02 2651 30 in in IN cord-014516-r59usk02 2651 31 CB CB NNP cord-014516-r59usk02 2651 32 dogs dog NNS cord-014516-r59usk02 2651 33 ( ( -LRB- cord-014516-r59usk02 2651 34 0 0 CD cord-014516-r59usk02 2651 35 % % NN cord-014516-r59usk02 2651 36 ) ) -RRB- cord-014516-r59usk02 2651 37 ( ( -LRB- cord-014516-r59usk02 2651 38 Khi² khi² JJ cord-014516-r59usk02 2651 39 test test NN cord-014516-r59usk02 2651 40 , , , cord-014516-r59usk02 2651 41 p p NN cord-014516-r59usk02 2651 42 = = SYM cord-014516-r59usk02 2651 43 0,009 0,009 CD cord-014516-r59usk02 2651 44 ) ) -RRB- cord-014516-r59usk02 2651 45 . . . cord-014516-r59usk02 2652 1 Presence presence NN cord-014516-r59usk02 2652 2 of of IN cord-014516-r59usk02 2652 3 Bb Bb NNP cord-014516-r59usk02 2652 4 in in IN cord-014516-r59usk02 2652 5 EBP ebp NN cord-014516-r59usk02 2652 6 dogs dog NNS cord-014516-r59usk02 2652 7 was be VBD cord-014516-r59usk02 2652 8 independant independant JJ cord-014516-r59usk02 2652 9 of of IN cord-014516-r59usk02 2652 10 age age NN cord-014516-r59usk02 2652 11 but but CC cord-014516-r59usk02 2652 12 significantly significantly RB cord-014516-r59usk02 2652 13 associated associate VBN cord-014516-r59usk02 2652 14 with with IN cord-014516-r59usk02 2652 15 CSS css NN cord-014516-r59usk02 2652 16 ( ( -LRB- cord-014516-r59usk02 2652 17 Khi² khi² JJ cord-014516-r59usk02 2652 18 test test NN cord-014516-r59usk02 2652 19 , , , cord-014516-r59usk02 2652 20 p p NN cord-014516-r59usk02 2652 21 = = SYM cord-014516-r59usk02 2652 22 0,041 0,041 CD cord-014516-r59usk02 2652 23 ) ) -RRB- cord-014516-r59usk02 2652 24 . . . cord-014516-r59usk02 2653 1 Results result NNS cord-014516-r59usk02 2653 2 of of IN cord-014516-r59usk02 2653 3 qPCRwere qPCRwere NNP cord-014516-r59usk02 2653 4 positive positive JJ cord-014516-r59usk02 2653 5 for for IN cord-014516-r59usk02 2653 6 M. M. NNP cord-014516-r59usk02 2653 7 canis canis NNP cord-014516-r59usk02 2653 8 and and CC cord-014516-r59usk02 2653 9 M. M. NNP cord-014516-r59usk02 2653 10 cynos cynos NN cord-014516-r59usk02 2653 11 in in IN cord-014516-r59usk02 2653 12 6 6 CD cord-014516-r59usk02 2653 13 ( ( -LRB- cord-014516-r59usk02 2653 14 33 33 CD cord-014516-r59usk02 2653 15 % % NN cord-014516-r59usk02 2653 16 ) ) -RRB- cord-014516-r59usk02 2653 17 and and CC cord-014516-r59usk02 2653 18 2 2 CD cord-014516-r59usk02 2653 19 ( ( -LRB- cord-014516-r59usk02 2653 20 11 11 CD cord-014516-r59usk02 2653 21 % % NN cord-014516-r59usk02 2653 22 ) ) -RRB- cord-014516-r59usk02 2653 23 EBP ebp NN cord-014516-r59usk02 2653 24 dogs dog NNS cord-014516-r59usk02 2653 25 and and CC cord-014516-r59usk02 2653 26 in in IN cord-014516-r59usk02 2653 27 1 1 CD cord-014516-r59usk02 2653 28 ( ( -LRB- cord-014516-r59usk02 2653 29 13 13 CD cord-014516-r59usk02 2653 30 % % NN cord-014516-r59usk02 2653 31 ) ) -RRB- cord-014516-r59usk02 2653 32 and and CC cord-014516-r59usk02 2653 33 1 1 CD cord-014516-r59usk02 2653 34 ( ( -LRB- cord-014516-r59usk02 2653 35 13 13 CD cord-014516-r59usk02 2653 36 % % NN cord-014516-r59usk02 2653 37 ) ) -RRB- cord-014516-r59usk02 2653 38 CB CB NNP cord-014516-r59usk02 2653 39 dogs dog NNS cord-014516-r59usk02 2653 40 , , , cord-014516-r59usk02 2653 41 respectively respectively RB cord-014516-r59usk02 2653 42 . . . cord-014516-r59usk02 2654 1 There there EX cord-014516-r59usk02 2654 2 was be VBD cord-014516-r59usk02 2654 3 no no DT cord-014516-r59usk02 2654 4 difference difference NN cord-014516-r59usk02 2654 5 between between IN cord-014516-r59usk02 2654 6 the the DT cord-014516-r59usk02 2654 7 2 2 CD cord-014516-r59usk02 2654 8 groups group NNS cord-014516-r59usk02 2654 9 for for IN cord-014516-r59usk02 2654 10 any any DT cord-014516-r59usk02 2654 11 of of IN cord-014516-r59usk02 2654 12 the the DT cord-014516-r59usk02 2654 13 organisms organism NNS cord-014516-r59usk02 2654 14 . . . cord-014516-r59usk02 2655 1 Any any DT cord-014516-r59usk02 2655 2 relation relation NN cord-014516-r59usk02 2655 3 between between IN cord-014516-r59usk02 2655 4 age age NN cord-014516-r59usk02 2655 5 or or CC cord-014516-r59usk02 2655 6 CSS css NN cord-014516-r59usk02 2655 7 and and CC cord-014516-r59usk02 2655 8 presence presence NN cord-014516-r59usk02 2655 9 of of IN cord-014516-r59usk02 2655 10 M. M. NNP cord-014516-r59usk02 2655 11 spp spp NN cord-014516-r59usk02 2655 12 in in IN cord-014516-r59usk02 2655 13 EBP ebp NN cord-014516-r59usk02 2655 14 dogs dog NNS cord-014516-r59usk02 2655 15 was be VBD cord-014516-r59usk02 2655 16 observed observe VBN cord-014516-r59usk02 2655 17 . . . cord-014516-r59usk02 2656 1 In in IN cord-014516-r59usk02 2656 2 conclusion conclusion NN cord-014516-r59usk02 2656 3 , , , cord-014516-r59usk02 2656 4 M. M. NNP cord-014516-r59usk02 2656 5 canis canis NNP cord-014516-r59usk02 2656 6 and and CC cord-014516-r59usk02 2656 7 M. M. NNP cord-014516-r59usk02 2656 8 cynos cynos NN cord-014516-r59usk02 2656 9 do do VBP cord-014516-r59usk02 2656 10 not not RB cord-014516-r59usk02 2656 11 seem seem VB cord-014516-r59usk02 2656 12 to to TO cord-014516-r59usk02 2656 13 be be VB cord-014516-r59usk02 2656 14 predominantly predominantly RB cord-014516-r59usk02 2656 15 involved involve VBN cord-014516-r59usk02 2656 16 in in IN cord-014516-r59usk02 2656 17 the the DT cord-014516-r59usk02 2656 18 pathogenesis pathogenesis NN cord-014516-r59usk02 2656 19 of of IN cord-014516-r59usk02 2656 20 canine canine JJ cord-014516-r59usk02 2656 21 EBP ebp NN cord-014516-r59usk02 2656 22 . . . cord-014516-r59usk02 2657 1 However however RB cord-014516-r59usk02 2657 2 , , , cord-014516-r59usk02 2657 3 Bb Bb NNP cord-014516-r59usk02 2657 4 is be VBZ cord-014516-r59usk02 2657 5 more more RBR cord-014516-r59usk02 2657 6 frequently frequently RB cord-014516-r59usk02 2657 7 detected detect VBN cord-014516-r59usk02 2657 8 in in IN cord-014516-r59usk02 2657 9 BALF BALF NNP cord-014516-r59usk02 2657 10 from from IN cord-014516-r59usk02 2657 11 EBP ebp NN cord-014516-r59usk02 2657 12 dogs dog NNS cord-014516-r59usk02 2657 13 than than IN cord-014516-r59usk02 2657 14 from from IN cord-014516-r59usk02 2657 15 dogs dog NNS cord-014516-r59usk02 2657 16 with with IN cord-014516-r59usk02 2657 17 aspecific aspecific NNP cord-014516-r59usk02 2657 18 CB CB NNP cord-014516-r59usk02 2657 19 and and CC cord-014516-r59usk02 2657 20 its -PRON- PRP$ cord-014516-r59usk02 2657 21 presence presence NN cord-014516-r59usk02 2657 22 is be VBZ cord-014516-r59usk02 2657 23 associated associate VBN cord-014516-r59usk02 2657 24 with with IN cord-014516-r59usk02 2657 25 clinical clinical JJ cord-014516-r59usk02 2657 26 severity severity NN cord-014516-r59usk02 2657 27 . . . cord-014516-r59usk02 2658 1 Whether whether IN cord-014516-r59usk02 2658 2 Bb Bb NNP cord-014516-r59usk02 2658 3 is be VBZ cord-014516-r59usk02 2658 4 able able JJ cord-014516-r59usk02 2658 5 to to TO cord-014516-r59usk02 2658 6 trigger trigger VB cord-014516-r59usk02 2658 7 eosinophilic eosinophilic JJ cord-014516-r59usk02 2658 8 inflammation inflammation NN cord-014516-r59usk02 2658 9 or or CC cord-014516-r59usk02 2658 10 is be VBZ cord-014516-r59usk02 2658 11 only only RB cord-014516-r59usk02 2658 12 more more RBR cord-014516-r59usk02 2658 13 easily easily RB cord-014516-r59usk02 2658 14 collected collect VBN cord-014516-r59usk02 2658 15 in in IN cord-014516-r59usk02 2658 16 an an DT cord-014516-r59usk02 2658 17 inflamed inflamed JJ cord-014516-r59usk02 2658 18 environment environment NN cord-014516-r59usk02 2658 19 is be VBZ cord-014516-r59usk02 2658 20 unclear unclear JJ cord-014516-r59usk02 2658 21 . . . cord-014516-r59usk02 2659 1 But but CC cord-014516-r59usk02 2659 2 EBP ebp NN cord-014516-r59usk02 2659 3 dogs dog NNS cord-014516-r59usk02 2659 4 could could MD cord-014516-r59usk02 2659 5 potentially potentially RB cord-014516-r59usk02 2659 6 act act VB cord-014516-r59usk02 2659 7 as as IN cord-014516-r59usk02 2659 8 Bb Bb NNP cord-014516-r59usk02 2659 9 carriers carrier NNS cord-014516-r59usk02 2659 10 and and CC cord-014516-r59usk02 2659 11 source source NN cord-014516-r59usk02 2659 12 of of IN cord-014516-r59usk02 2659 13 infection infection NN cord-014516-r59usk02 2659 14 . . . cord-014516-r59usk02 2660 1 Therefore therefore RB cord-014516-r59usk02 2660 2 , , , cord-014516-r59usk02 2660 3 Bb Bb NNP cord-014516-r59usk02 2660 4 should should MD cord-014516-r59usk02 2660 5 be be VB cord-014516-r59usk02 2660 6 systematically systematically RB cord-014516-r59usk02 2660 7 searched search VBN cord-014516-r59usk02 2660 8 for for IN cord-014516-r59usk02 2660 9 in in IN cord-014516-r59usk02 2660 10 canine canine JJ cord-014516-r59usk02 2660 11 EBP ebp NN cord-014516-r59usk02 2660 12 cases case NNS cord-014516-r59usk02 2660 13 and and CC cord-014516-r59usk02 2660 14 treated treat VBN cord-014516-r59usk02 2660 15 accordingly accordingly RB cord-014516-r59usk02 2660 16 . . . cord-014516-r59usk02 2661 1 No no DT cord-014516-r59usk02 2661 2 conflicts conflict NNS cord-014516-r59usk02 2661 3 of of IN cord-014516-r59usk02 2661 4 interest interest NN cord-014516-r59usk02 2661 5 reported report VBN cord-014516-r59usk02 2661 6 . . . cord-014516-r59usk02 2662 1 Distal distal JJ cord-014516-r59usk02 2662 2 renal renal JJ cord-014516-r59usk02 2662 3 distal distal JJ cord-014516-r59usk02 2662 4 renal renal JJ cord-014516-r59usk02 2662 5 tubular tubular JJ cord-014516-r59usk02 2662 6 acidosis acidosis NN cord-014516-r59usk02 2662 7 ( ( -LRB- cord-014516-r59usk02 2662 8 dRTA dRTA NNP cord-014516-r59usk02 2662 9 ) ) -RRB- cord-014516-r59usk02 2662 10 was be VBD cord-014516-r59usk02 2662 11 recently recently RB cord-014516-r59usk02 2662 12 reported report VBN cord-014516-r59usk02 2662 13 in in IN cord-014516-r59usk02 2662 14 three three CD cord-014516-r59usk02 2662 15 dogs dog NNS cord-014516-r59usk02 2662 16 with with IN cord-014516-r59usk02 2662 17 IMHA IMHA NNP cord-014516-r59usk02 2662 18 . . . cord-014516-r59usk02 2663 1 The the DT cord-014516-r59usk02 2663 2 purpose purpose NN cord-014516-r59usk02 2663 3 of of IN cord-014516-r59usk02 2663 4 this this DT cord-014516-r59usk02 2663 5 study study NN cord-014516-r59usk02 2663 6 was be VBD cord-014516-r59usk02 2663 7 to to TO cord-014516-r59usk02 2663 8 explore explore VB cord-014516-r59usk02 2663 9 the the DT cord-014516-r59usk02 2663 10 hypothesis hypothesis NN cord-014516-r59usk02 2663 11 that that IN cord-014516-r59usk02 2663 12 dRTA dRTA NNP cord-014516-r59usk02 2663 13 is be VBZ cord-014516-r59usk02 2663 14 an an DT cord-014516-r59usk02 2663 15 underdiagnosed underdiagnosed JJ cord-014516-r59usk02 2663 16 concurrent concurrent JJ cord-014516-r59usk02 2663 17 disorder disorder NN cord-014516-r59usk02 2663 18 in in IN cord-014516-r59usk02 2663 19 dogs dog NNS cord-014516-r59usk02 2663 20 with with IN cord-014516-r59usk02 2663 21 IMHA IMHA NNP cord-014516-r59usk02 2663 22 . . . cord-014516-r59usk02 2664 1 We -PRON- PRP cord-014516-r59usk02 2664 2 report report VBP cord-014516-r59usk02 2664 3 the the DT cord-014516-r59usk02 2664 4 clinical clinical JJ cord-014516-r59usk02 2664 5 presentation presentation NN cord-014516-r59usk02 2664 6 and and CC cord-014516-r59usk02 2664 7 outcome outcome NN cord-014516-r59usk02 2664 8 of of IN cord-014516-r59usk02 2664 9 three three CD cord-014516-r59usk02 2664 10 dogs dog NNS cord-014516-r59usk02 2664 11 where where WRB cord-014516-r59usk02 2664 12 the the DT cord-014516-r59usk02 2664 13 combination combination NN cord-014516-r59usk02 2664 14 of of IN cord-014516-r59usk02 2664 15 IMHA IMHA NNP cord-014516-r59usk02 2664 16 and and CC cord-014516-r59usk02 2664 17 dRTA dRTA NNP cord-014516-r59usk02 2664 18 was be VBD cord-014516-r59usk02 2664 19 strongly strongly RB cord-014516-r59usk02 2664 20 suspected suspect VBN cord-014516-r59usk02 2664 21 . . . cord-014516-r59usk02 2665 1 The the DT cord-014516-r59usk02 2665 2 medical medical JJ cord-014516-r59usk02 2665 3 records record NNS cord-014516-r59usk02 2665 4 of of IN cord-014516-r59usk02 2665 5 dogs dog NNS cord-014516-r59usk02 2665 6 diagnosed diagnose VBN cord-014516-r59usk02 2665 7 with with IN cord-014516-r59usk02 2665 8 IMHA IMHA NNP cord-014516-r59usk02 2665 9 at at IN cord-014516-r59usk02 2665 10 the the DT cord-014516-r59usk02 2665 11 University University NNP cord-014516-r59usk02 2665 12 of of IN cord-014516-r59usk02 2665 13 Edinburgh Edinburgh NNP cord-014516-r59usk02 2665 14 Hospital Hospital NNP cord-014516-r59usk02 2665 15 for for IN cord-014516-r59usk02 2665 16 Small small JJ cord-014516-r59usk02 2665 17 Animals Animals NNPS cord-014516-r59usk02 2665 18 between between IN cord-014516-r59usk02 2665 19 January January NNP cord-014516-r59usk02 2665 20 2008 2008 CD cord-014516-r59usk02 2665 21 and and CC cord-014516-r59usk02 2665 22 May May NNP cord-014516-r59usk02 2665 23 2013 2013 CD cord-014516-r59usk02 2665 24 were be VBD cord-014516-r59usk02 2665 25 reviewed review VBN cord-014516-r59usk02 2665 26 to to TO cord-014516-r59usk02 2665 27 identify identify VB cord-014516-r59usk02 2665 28 cases case NNS cord-014516-r59usk02 2665 29 where where WRB cord-014516-r59usk02 2665 30 venous venous JJ cord-014516-r59usk02 2665 31 blood blood NN cord-014516-r59usk02 2665 32 gas gas NN cord-014516-r59usk02 2665 33 analysis analysis NN cord-014516-r59usk02 2665 34 and and CC cord-014516-r59usk02 2665 35 urinalysis urinalysis NN cord-014516-r59usk02 2665 36 had have VBD cord-014516-r59usk02 2665 37 also also RB cord-014516-r59usk02 2665 38 been be VBN cord-014516-r59usk02 2665 39 carried carry VBN cord-014516-r59usk02 2665 40 out out RP cord-014516-r59usk02 2665 41 . . . cord-014516-r59usk02 2666 1 For for IN cord-014516-r59usk02 2666 2 the the DT cord-014516-r59usk02 2666 3 purpose purpose NN cord-014516-r59usk02 2666 4 of of IN cord-014516-r59usk02 2666 5 this this DT cord-014516-r59usk02 2666 6 retrospective retrospective JJ cord-014516-r59usk02 2666 7 study study NN cord-014516-r59usk02 2666 8 IMHA IMHA NNP cord-014516-r59usk02 2666 9 was be VBD cord-014516-r59usk02 2666 10 defined define VBN cord-014516-r59usk02 2666 11 by by IN cord-014516-r59usk02 2666 12 the the DT cord-014516-r59usk02 2666 13 presence presence NN cord-014516-r59usk02 2666 14 of of IN cord-014516-r59usk02 2666 15 anaemia anaemia NN cord-014516-r59usk02 2666 16 with with IN cord-014516-r59usk02 2666 17 PCV PCV NNP cord-014516-r59usk02 2666 18 < < XX cord-014516-r59usk02 2666 19 30 30 CD cord-014516-r59usk02 2666 20 % % NN cord-014516-r59usk02 2666 21 , , , cord-014516-r59usk02 2666 22 and and CC cord-014516-r59usk02 2666 23 one one CD cord-014516-r59usk02 2666 24 or or CC cord-014516-r59usk02 2666 25 more more JJR cord-014516-r59usk02 2666 26 of of IN cord-014516-r59usk02 2666 27 the the DT cord-014516-r59usk02 2666 28 following follow VBG cord-014516-r59usk02 2666 29 criteria criterion NNS cord-014516-r59usk02 2666 30 ; ; : cord-014516-r59usk02 2666 31 a a DT cord-014516-r59usk02 2666 32 positive positive JJ cord-014516-r59usk02 2666 33 slide slide NN cord-014516-r59usk02 2666 34 agglutination agglutination NN cord-014516-r59usk02 2666 35 test test NN cord-014516-r59usk02 2666 36 , , , cord-014516-r59usk02 2666 37 positive positive JJ cord-014516-r59usk02 2666 38 Coombs Coombs NNP cord-014516-r59usk02 2666 39 ' ' POS cord-014516-r59usk02 2666 40 test test NN cord-014516-r59usk02 2666 41 or or CC cord-014516-r59usk02 2666 42 moderate moderate JJ cord-014516-r59usk02 2666 43 to to IN cord-014516-r59usk02 2666 44 marked marked JJ cord-014516-r59usk02 2666 45 spherocytosis spherocytosis NN cord-014516-r59usk02 2666 46 . . . cord-014516-r59usk02 2667 1 The the DT cord-014516-r59usk02 2667 2 criteria criterion NNS cord-014516-r59usk02 2667 3 for for IN cord-014516-r59usk02 2667 4 diagnosis diagnosis NN cord-014516-r59usk02 2667 5 of of IN cord-014516-r59usk02 2667 6 dRTA dRTA NNP cord-014516-r59usk02 2667 7 included include VBN cord-014516-r59usk02 2667 8 moderate moderate JJ cord-014516-r59usk02 2667 9 to to IN cord-014516-r59usk02 2667 10 marked mark VBN cord-014516-r59usk02 2667 11 hyperchloremic hyperchloremic JJ cord-014516-r59usk02 2667 12 metabolic metabolic JJ cord-014516-r59usk02 2667 13 acidosis acidosis NN cord-014516-r59usk02 2667 14 with with IN cord-014516-r59usk02 2667 15 a a DT cord-014516-r59usk02 2667 16 normal normal JJ cord-014516-r59usk02 2667 17 anion anion NN cord-014516-r59usk02 2667 18 gap gap NN cord-014516-r59usk02 2667 19 ; ; : cord-014516-r59usk02 2667 20 urine urine NN cord-014516-r59usk02 2667 21 pH ph NN cord-014516-r59usk02 2667 22 ( ( -LRB- cord-014516-r59usk02 2667 23 > > NFP cord-014516-r59usk02 2667 24 6.0 6.0 CD cord-014516-r59usk02 2667 25 ) ) -RRB- cord-014516-r59usk02 2667 26 in in IN cord-014516-r59usk02 2667 27 the the DT cord-014516-r59usk02 2667 28 face face NN cord-014516-r59usk02 2667 29 of of IN cord-014516-r59usk02 2667 30 metabolic metabolic JJ cord-014516-r59usk02 2667 31 acidosis acidosis NN cord-014516-r59usk02 2667 32 ; ; : cord-014516-r59usk02 2667 33 hypokalaemia hypokalaemia NN cord-014516-r59usk02 2667 34 ( ( -LRB- cord-014516-r59usk02 2667 35 < < NNP cord-014516-r59usk02 2667 36 3.5 3.5 CD cord-014516-r59usk02 2667 37 mmol mmol JJ cord-014516-r59usk02 2667 38 / / SYM cord-014516-r59usk02 2667 39 l l NN cord-014516-r59usk02 2667 40 ) ) -RRB- cord-014516-r59usk02 2667 41 . . . cord-014516-r59usk02 2668 1 Fifty fifty CD cord-014516-r59usk02 2668 2 - - HYPH cord-014516-r59usk02 2668 3 seven seven CD cord-014516-r59usk02 2668 4 records record NNS cord-014516-r59usk02 2668 5 were be VBD cord-014516-r59usk02 2668 6 evaluated evaluate VBN cord-014516-r59usk02 2668 7 , , , cord-014516-r59usk02 2668 8 with with IN cord-014516-r59usk02 2668 9 39 39 CD cord-014516-r59usk02 2668 10 cases case NNS cord-014516-r59usk02 2668 11 being be VBG cord-014516-r59usk02 2668 12 excluded exclude VBN cord-014516-r59usk02 2668 13 due due IN cord-014516-r59usk02 2668 14 to to IN cord-014516-r59usk02 2668 15 insufficient insufficient JJ cord-014516-r59usk02 2668 16 clinical clinical JJ cord-014516-r59usk02 2668 17 information information NN cord-014516-r59usk02 2668 18 , , , cord-014516-r59usk02 2668 19 including include VBG cord-014516-r59usk02 2668 20 inability inability NN cord-014516-r59usk02 2668 21 to to TO cord-014516-r59usk02 2668 22 determine determine VB cord-014516-r59usk02 2668 23 urinary urinary JJ cord-014516-r59usk02 2668 24 pH ph NN cord-014516-r59usk02 2668 25 due due IN cord-014516-r59usk02 2668 26 to to IN cord-014516-r59usk02 2668 27 the the DT cord-014516-r59usk02 2668 28 severity severity NN cord-014516-r59usk02 2668 29 of of IN cord-014516-r59usk02 2668 30 pigmenturia pigmenturia NNS cord-014516-r59usk02 2668 31 in in IN cord-014516-r59usk02 2668 32 four four CD cord-014516-r59usk02 2668 33 cases case NNS cord-014516-r59usk02 2668 34 . . . cord-014516-r59usk02 2669 1 Of of IN cord-014516-r59usk02 2669 2 the the DT cord-014516-r59usk02 2669 3 18 18 CD cord-014516-r59usk02 2669 4 cases case NNS cord-014516-r59usk02 2669 5 where where WRB cord-014516-r59usk02 2669 6 there there EX cord-014516-r59usk02 2669 7 was be VBD cord-014516-r59usk02 2669 8 sufficient sufficient JJ cord-014516-r59usk02 2669 9 clinical clinical JJ cord-014516-r59usk02 2669 10 data datum NNS cord-014516-r59usk02 2669 11 to to TO cord-014516-r59usk02 2669 12 assess assess VB cord-014516-r59usk02 2669 13 the the DT cord-014516-r59usk02 2669 14 likelihood likelihood NN cord-014516-r59usk02 2669 15 of of IN cord-014516-r59usk02 2669 16 dRTA dRTA `` cord-014516-r59usk02 2669 17 only only RB cord-014516-r59usk02 2669 18 one one CD cord-014516-r59usk02 2669 19 case case NN cord-014516-r59usk02 2669 20 fulfilled fulfil VBD cord-014516-r59usk02 2669 21 all all PDT cord-014516-r59usk02 2669 22 the the DT cord-014516-r59usk02 2669 23 criteria criterion NNS cord-014516-r59usk02 2669 24 ; ; : cord-014516-r59usk02 2669 25 two two CD cord-014516-r59usk02 2669 26 cases case NNS cord-014516-r59usk02 2669 27 fulfilled fulfil VBD cord-014516-r59usk02 2669 28 all all DT cord-014516-r59usk02 2669 29 but but IN cord-014516-r59usk02 2669 30 one one CD cord-014516-r59usk02 2669 31 of of IN cord-014516-r59usk02 2669 32 the the DT cord-014516-r59usk02 2669 33 criteria criterion NNS cord-014516-r59usk02 2669 34 and and CC cord-014516-r59usk02 2669 35 dRTA dRTA NNP cord-014516-r59usk02 2669 36 was be VBD cord-014516-r59usk02 2669 37 strongly strongly RB cord-014516-r59usk02 2669 38 suspected suspect VBN cord-014516-r59usk02 2669 39 based base VBN cord-014516-r59usk02 2669 40 on on IN cord-014516-r59usk02 2669 41 clinical clinical JJ cord-014516-r59usk02 2669 42 progression progression NN cord-014516-r59usk02 2669 43 and and CC cord-014516-r59usk02 2669 44 persistence persistence NN cord-014516-r59usk02 2669 45 of of IN cord-014516-r59usk02 2669 46 urine urine NN cord-014516-r59usk02 2669 47 pH ph NN cord-014516-r59usk02 2669 48 > > XX cord-014516-r59usk02 2670 1 6 6 CD cord-014516-r59usk02 2670 2 in in IN cord-014516-r59usk02 2670 3 the the DT cord-014516-r59usk02 2670 4 face face NN cord-014516-r59usk02 2670 5 of of IN cord-014516-r59usk02 2670 6 severe severe JJ cord-014516-r59usk02 2670 7 metabolic metabolic JJ cord-014516-r59usk02 2670 8 acidosis acidosis NN cord-014516-r59usk02 2670 9 . . . cord-014516-r59usk02 2671 1 Of of IN cord-014516-r59usk02 2671 2 the the DT cord-014516-r59usk02 2671 3 three three CD cord-014516-r59usk02 2671 4 cases case NNS cord-014516-r59usk02 2671 5 where where WRB cord-014516-r59usk02 2671 6 concurrent concurrent JJ cord-014516-r59usk02 2671 7 IMHA IMHA NNP cord-014516-r59usk02 2671 8 and and CC cord-014516-r59usk02 2671 9 dRTA dRTA NNP cord-014516-r59usk02 2671 10 was be VBD cord-014516-r59usk02 2671 11 suspected suspect VBN cord-014516-r59usk02 2671 12 , , , cord-014516-r59usk02 2671 13 two two CD cord-014516-r59usk02 2671 14 survived survive VBD cord-014516-r59usk02 2671 15 to to TO cord-014516-r59usk02 2671 16 discharge discharge VB cord-014516-r59usk02 2671 17 ; ; : cord-014516-r59usk02 2671 18 one one CD cord-014516-r59usk02 2671 19 was be VBD cord-014516-r59usk02 2671 20 still still RB cord-014516-r59usk02 2671 21 alive alive JJ cord-014516-r59usk02 2671 22 at at IN cord-014516-r59usk02 2671 23 the the DT cord-014516-r59usk02 2671 24 time time NN cord-014516-r59usk02 2671 25 of of IN cord-014516-r59usk02 2671 26 writing writing NN cord-014516-r59usk02 2671 27 ( ( -LRB- cord-014516-r59usk02 2671 28 13 13 CD cord-014516-r59usk02 2671 29 months month NNS cord-014516-r59usk02 2671 30 after after IN cord-014516-r59usk02 2671 31 discharge discharge NN cord-014516-r59usk02 2671 32 ) ) -RRB- cord-014516-r59usk02 2671 33 and and CC cord-014516-r59usk02 2671 34 the the DT cord-014516-r59usk02 2671 35 other other JJ cord-014516-r59usk02 2671 36 was be VBD cord-014516-r59usk02 2671 37 euthanased euthanase VBN cord-014516-r59usk02 2671 38 2 2 CD cord-014516-r59usk02 2671 39 months month NNS cord-014516-r59usk02 2671 40 after after IN cord-014516-r59usk02 2671 41 discharge discharge NN cord-014516-r59usk02 2671 42 following follow VBG cord-014516-r59usk02 2671 43 the the DT cord-014516-r59usk02 2671 44 development development NN cord-014516-r59usk02 2671 45 of of IN cord-014516-r59usk02 2671 46 multiple multiple JJ cord-014516-r59usk02 2671 47 joint joint JJ cord-014516-r59usk02 2671 48 effusions effusion NNS cord-014516-r59usk02 2671 49 and and CC cord-014516-r59usk02 2671 50 skin skin NN cord-014516-r59usk02 2671 51 lesions lesion NNS cord-014516-r59usk02 2671 52 suggestive suggestive JJ cord-014516-r59usk02 2671 53 of of IN cord-014516-r59usk02 2671 54 SLE SLE NNP cord-014516-r59usk02 2671 55 . . . cord-014516-r59usk02 2672 1 Venous venous JJ cord-014516-r59usk02 2672 2 blood blood NN cord-014516-r59usk02 2672 3 gas gas NN cord-014516-r59usk02 2672 4 analysis analysis NN cord-014516-r59usk02 2672 5 and and CC cord-014516-r59usk02 2672 6 assessment assessment NN cord-014516-r59usk02 2672 7 of of IN cord-014516-r59usk02 2672 8 urine urine NN cord-014516-r59usk02 2672 9 pH ph NN cord-014516-r59usk02 2672 10 should should MD cord-014516-r59usk02 2672 11 be be VB cord-014516-r59usk02 2672 12 considered consider VBN cord-014516-r59usk02 2672 13 in in IN cord-014516-r59usk02 2672 14 all all DT cord-014516-r59usk02 2672 15 cases case NNS cord-014516-r59usk02 2672 16 of of IN cord-014516-r59usk02 2672 17 IMHA IMHA NNP cord-014516-r59usk02 2672 18 to to TO cord-014516-r59usk02 2672 19 exclude exclude VB cord-014516-r59usk02 2672 20 the the DT cord-014516-r59usk02 2672 21 possibility possibility NN cord-014516-r59usk02 2672 22 of of IN cord-014516-r59usk02 2672 23 concurrent concurrent JJ cord-014516-r59usk02 2672 24 dRTA drta NN cord-014516-r59usk02 2672 25 , , , cord-014516-r59usk02 2672 26 particularly particularly RB cord-014516-r59usk02 2672 27 where where WRB cord-014516-r59usk02 2672 28 persistent persistent JJ cord-014516-r59usk02 2672 29 hypokalaemia hypokalaemia NN cord-014516-r59usk02 2672 30 is be VBZ cord-014516-r59usk02 2672 31 detected detect VBN cord-014516-r59usk02 2672 32 . . . cord-014516-r59usk02 2673 1 Prospective prospective JJ cord-014516-r59usk02 2673 2 evaluation evaluation NN cord-014516-r59usk02 2673 3 of of IN cord-014516-r59usk02 2673 4 a a DT cord-014516-r59usk02 2673 5 larger large JJR cord-014516-r59usk02 2673 6 cohort cohort NN cord-014516-r59usk02 2673 7 of of IN cord-014516-r59usk02 2673 8 IMHA IMHA NNP cord-014516-r59usk02 2673 9 cases case NNS cord-014516-r59usk02 2673 10 is be VBZ cord-014516-r59usk02 2673 11 required require VBN cord-014516-r59usk02 2673 12 to to TO cord-014516-r59usk02 2673 13 determine determine VB cord-014516-r59usk02 2673 14 the the DT cord-014516-r59usk02 2673 15 actual actual JJ cord-014516-r59usk02 2673 16 incidence incidence NN cord-014516-r59usk02 2673 17 of of IN cord-014516-r59usk02 2673 18 concurrent concurrent JJ cord-014516-r59usk02 2673 19 dRTA drta NN cord-014516-r59usk02 2673 20 . . . cord-014516-r59usk02 2674 1 No no DT cord-014516-r59usk02 2674 2 conflicts conflict NNS cord-014516-r59usk02 2674 3 of of IN cord-014516-r59usk02 2674 4 interest interest NN cord-014516-r59usk02 2674 5 reported report VBN cord-014516-r59usk02 2674 6 . . . cord-014516-r59usk02 2675 1 Persistent persistent JJ cord-014516-r59usk02 2675 2 renal renal JJ cord-014516-r59usk02 2675 3 proteinuria proteinuria NN cord-014516-r59usk02 2675 4 is be VBZ cord-014516-r59usk02 2675 5 considered consider VBN cord-014516-r59usk02 2675 6 an an DT cord-014516-r59usk02 2675 7 early early JJ cord-014516-r59usk02 2675 8 marker marker NN cord-014516-r59usk02 2675 9 of of IN cord-014516-r59usk02 2675 10 chronic chronic JJ cord-014516-r59usk02 2675 11 kidney kidney NN cord-014516-r59usk02 2675 12 disease disease NN cord-014516-r59usk02 2675 13 ( ( -LRB- cord-014516-r59usk02 2675 14 CKD CKD NNP cord-014516-r59usk02 2675 15 ) ) -RRB- cord-014516-r59usk02 2675 16 and and CC cord-014516-r59usk02 2675 17 it -PRON- PRP cord-014516-r59usk02 2675 18 is be VBZ cord-014516-r59usk02 2675 19 listed list VBN cord-014516-r59usk02 2675 20 among among IN cord-014516-r59usk02 2675 21 the the DT cord-014516-r59usk02 2675 22 initiation initiation NN cord-014516-r59usk02 2675 23 factors factor NNS cord-014516-r59usk02 2675 24 and and CC cord-014516-r59usk02 2675 25 progression progression NN cord-014516-r59usk02 2675 26 factors factor NNS cord-014516-r59usk02 2675 27 according accord VBG cord-014516-r59usk02 2675 28 to to IN cord-014516-r59usk02 2675 29 KDOQI KDOQI NNP cord-014516-r59usk02 2675 30 guidelines guideline NNS cord-014516-r59usk02 2675 31 . . . cord-014516-r59usk02 2676 1 Nevertheless nevertheless RB cord-014516-r59usk02 2676 2 , , , cord-014516-r59usk02 2676 3 few few JJ cord-014516-r59usk02 2676 4 data datum NNS cord-014516-r59usk02 2676 5 are be VBP cord-014516-r59usk02 2676 6 available available JJ cord-014516-r59usk02 2676 7 about about IN cord-014516-r59usk02 2676 8 the the DT cord-014516-r59usk02 2676 9 prevalence prevalence NN cord-014516-r59usk02 2676 10 of of IN cord-014516-r59usk02 2676 11 proteinuria proteinuria NN cord-014516-r59usk02 2676 12 in in IN cord-014516-r59usk02 2676 13 cats cat NNS cord-014516-r59usk02 2676 14 affected affect VBN cord-014516-r59usk02 2676 15 with with IN cord-014516-r59usk02 2676 16 CKD CKD NNP cord-014516-r59usk02 2676 17 , , , cord-014516-r59usk02 2676 18 in in IN cord-014516-r59usk02 2676 19 which which WDT cord-014516-r59usk02 2676 20 it -PRON- PRP cord-014516-r59usk02 2676 21 is be VBZ cord-014516-r59usk02 2676 22 assumed assume VBN cord-014516-r59usk02 2676 23 that that IN cord-014516-r59usk02 2676 24 nephropathy nephropathy NN cord-014516-r59usk02 2676 25 is be VBZ cord-014516-r59usk02 2676 26 mainly mainly RB cord-014516-r59usk02 2676 27 characterized characterize VBN cord-014516-r59usk02 2676 28 by by IN cord-014516-r59usk02 2676 29 tubulointerstitial tubulointerstitial JJ cord-014516-r59usk02 2676 30 damage damage NN cord-014516-r59usk02 2676 31 . . . cord-014516-r59usk02 2677 1 The the DT cord-014516-r59usk02 2677 2 aim aim NN cord-014516-r59usk02 2677 3 of of IN cord-014516-r59usk02 2677 4 this this DT cord-014516-r59usk02 2677 5 study study NN cord-014516-r59usk02 2677 6 is be VBZ cord-014516-r59usk02 2677 7 to to TO cord-014516-r59usk02 2677 8 determine determine VB cord-014516-r59usk02 2677 9 the the DT cord-014516-r59usk02 2677 10 prevalence prevalence NN cord-014516-r59usk02 2677 11 of of IN cord-014516-r59usk02 2677 12 proteinuria proteinuria NN cord-014516-r59usk02 2677 13 in in IN cord-014516-r59usk02 2677 14 cats cat NNS cord-014516-r59usk02 2677 15 affected affect VBN cord-014516-r59usk02 2677 16 with with IN cord-014516-r59usk02 2677 17 CKD CKD NNP cord-014516-r59usk02 2677 18 and and CC cord-014516-r59usk02 2677 19 to to TO cord-014516-r59usk02 2677 20 valuate valuate VB cord-014516-r59usk02 2677 21 the the DT cord-014516-r59usk02 2677 22 relations relation NNS cord-014516-r59usk02 2677 23 between between IN cord-014516-r59usk02 2677 24 urine urine NN cord-014516-r59usk02 2677 25 protein protein NN cord-014516-r59usk02 2677 26 to to IN cord-014516-r59usk02 2677 27 creatinine creatinine NN cord-014516-r59usk02 2677 28 ratio ratio NN cord-014516-r59usk02 2677 29 ( ( -LRB- cord-014516-r59usk02 2677 30 UPC UPC NNP cord-014516-r59usk02 2677 31 ) ) -RRB- cord-014516-r59usk02 2677 32 or or CC cord-014516-r59usk02 2677 33 IRIS IRIS NNP cord-014516-r59usk02 2677 34 substaging substaging NN cord-014516-r59usk02 2677 35 by by IN cord-014516-r59usk02 2677 36 proteinuria proteinuria NN cord-014516-r59usk02 2677 37 , , , cord-014516-r59usk02 2677 38 towards towards IN cord-014516-r59usk02 2677 39 purebred purebred JJ cord-014516-r59usk02 2677 40 , , , cord-014516-r59usk02 2677 41 sex sex NN cord-014516-r59usk02 2677 42 , , , cord-014516-r59usk02 2677 43 age age NN cord-014516-r59usk02 2677 44 , , , cord-014516-r59usk02 2677 45 haematology haematology NN cord-014516-r59usk02 2677 46 , , , cord-014516-r59usk02 2677 47 biochemistry biochemistry NN cord-014516-r59usk02 2677 48 and and CC cord-014516-r59usk02 2677 49 urinalysis urinalysis NN cord-014516-r59usk02 2677 50 . . . cord-014516-r59usk02 2678 1 Wilcoxon Wilcoxon NNP cord-014516-r59usk02 2678 2 test test NN cord-014516-r59usk02 2678 3 , , , cord-014516-r59usk02 2678 4 linear linear JJ cord-014516-r59usk02 2678 5 regression regression NN cord-014516-r59usk02 2678 6 and and CC cord-014516-r59usk02 2678 7 chi chi JJ cord-014516-r59usk02 2678 8 - - JJ cord-014516-r59usk02 2678 9 square square JJ cord-014516-r59usk02 2678 10 test test NN cord-014516-r59usk02 2678 11 were be VBD cord-014516-r59usk02 2678 12 used use VBN cord-014516-r59usk02 2678 13 for for IN cord-014516-r59usk02 2678 14 the the DT cord-014516-r59usk02 2678 15 statistical statistical JJ cord-014516-r59usk02 2678 16 analysis analysis NN cord-014516-r59usk02 2678 17 . . . cord-014516-r59usk02 2679 1 Data datum NNS cord-014516-r59usk02 2679 2 from from IN cord-014516-r59usk02 2679 3 251 251 CD cord-014516-r59usk02 2679 4 cats cat NNS cord-014516-r59usk02 2679 5 were be VBD cord-014516-r59usk02 2679 6 considered consider VBN cord-014516-r59usk02 2679 7 . . . cord-014516-r59usk02 2680 1 Non non JJ cord-014516-r59usk02 2680 2 - - JJ cord-014516-r59usk02 2680 3 renal renal JJ cord-014516-r59usk02 2680 4 proteinuria proteinuria NN cord-014516-r59usk02 2680 5 was be VBD cord-014516-r59usk02 2680 6 an an DT cord-014516-r59usk02 2680 7 exclusion exclusion NN cord-014516-r59usk02 2680 8 criterion criterion NN cord-014516-r59usk02 2680 9 . . . cord-014516-r59usk02 2681 1 Proteinuric proteinuric JJ cord-014516-r59usk02 2681 2 cats cat NNS cord-014516-r59usk02 2681 3 ( ( -LRB- cord-014516-r59usk02 2681 4 UPC>0.4 upc>0.4 CD cord-014516-r59usk02 2681 5 ) ) -RRB- cord-014516-r59usk02 2681 6 were be VBD cord-014516-r59usk02 2681 7 15.4 15.4 CD cord-014516-r59usk02 2681 8 % % NN cord-014516-r59usk02 2681 9 in in IN cord-014516-r59usk02 2681 10 CKD CKD NNP cord-014516-r59usk02 2681 11 cats cat NNS cord-014516-r59usk02 2681 12 , , , cord-014516-r59usk02 2681 13 while while IN cord-014516-r59usk02 2681 14 15.9 15.9 CD cord-014516-r59usk02 2681 15 % % NN cord-014516-r59usk02 2681 16 could could MD cord-014516-r59usk02 2681 17 be be VB cord-014516-r59usk02 2681 18 substaged substage VBN cord-014516-r59usk02 2681 19 as as IN cord-014516-r59usk02 2681 20 bordeline bordeline JJ cord-014516-r59usk02 2681 21 proteinuric proteinuric NNP cord-014516-r59usk02 2681 22 ( ( -LRB- cord-014516-r59usk02 2681 23 0.2 0.2 CD cord-014516-r59usk02 2681 24 ) ) -RRB- cord-014516-r59usk02 2682 1 In in IN cord-014516-r59usk02 2682 2 cats cat NNS cord-014516-r59usk02 2682 3 , , , cord-014516-r59usk02 2682 4 proteinuria proteinuria NN cord-014516-r59usk02 2682 5 tends tend VBZ cord-014516-r59usk02 2682 6 to to TO cord-014516-r59usk02 2682 7 increase increase VB cord-014516-r59usk02 2682 8 with with IN cord-014516-r59usk02 2682 9 aging age VBG cord-014516-r59usk02 2682 10 ( ( -LRB- cord-014516-r59usk02 2682 11 p p NN cord-014516-r59usk02 2682 12 < < XX cord-014516-r59usk02 2682 13 0.0001 0.0001 CD cord-014516-r59usk02 2682 14 ) ) -RRB- cord-014516-r59usk02 2682 15 and and CC cord-014516-r59usk02 2682 16 with with IN cord-014516-r59usk02 2682 17 worsening worsen VBG cord-014516-r59usk02 2682 18 of of IN cord-014516-r59usk02 2682 19 the the DT cord-014516-r59usk02 2682 20 nephropathy nephropathy NN cord-014516-r59usk02 2682 21 ( ( -LRB- cord-014516-r59usk02 2682 22 p p NN cord-014516-r59usk02 2682 23 = = SYM cord-014516-r59usk02 2682 24 0.002 0.002 CD cord-014516-r59usk02 2682 25 ) ) -RRB- cord-014516-r59usk02 2682 26 . . . cord-014516-r59usk02 2683 1 Proteinuria Proteinuria NNP cord-014516-r59usk02 2683 2 was be VBD cord-014516-r59usk02 2683 3 related relate VBN cord-014516-r59usk02 2683 4 to to IN cord-014516-r59usk02 2683 5 the the DT cord-014516-r59usk02 2683 6 anaemic anaemic JJ cord-014516-r59usk02 2683 7 state state NN cord-014516-r59usk02 2683 8 in in IN cord-014516-r59usk02 2683 9 CKD CKD NNP cord-014516-r59usk02 2683 10 cats cat NNS cord-014516-r59usk02 2683 11 : : : cord-014516-r59usk02 2683 12 UPC UPC NNP cord-014516-r59usk02 2683 13 significantly significantly RB cord-014516-r59usk02 2683 14 increases increase VBZ cord-014516-r59usk02 2683 15 with with IN cord-014516-r59usk02 2683 16 RBC RBC NNP cord-014516-r59usk02 2683 17 count count NN cord-014516-r59usk02 2683 18 , , , cord-014516-r59usk02 2683 19 Hb Hb NNP cord-014516-r59usk02 2683 20 , , , cord-014516-r59usk02 2683 21 Ht Ht NNP cord-014516-r59usk02 2683 22 and and CC cord-014516-r59usk02 2683 23 MCH MCH NNP cord-014516-r59usk02 2683 24 decreasing decrease VBG cord-014516-r59usk02 2683 25 ( ( -LRB- cord-014516-r59usk02 2683 26 p p NN cord-014516-r59usk02 2683 27 < < XX cord-014516-r59usk02 2683 28 0.0001 0.0001 CD cord-014516-r59usk02 2683 29 and and CC cord-014516-r59usk02 2683 30 p p NN cord-014516-r59usk02 2683 31 = = SYM cord-014516-r59usk02 2683 32 0.049 0.049 CD cord-014516-r59usk02 2683 33 respectively respectively RB cord-014516-r59usk02 2683 34 ) ) -RRB- cord-014516-r59usk02 2683 35 . . . cord-014516-r59usk02 2684 1 Proteinuria Proteinuria NNP cord-014516-r59usk02 2684 2 tends tend VBZ cord-014516-r59usk02 2684 3 to to TO cord-014516-r59usk02 2684 4 increase increase VB cord-014516-r59usk02 2684 5 with with IN cord-014516-r59usk02 2684 6 WBC WBC NNP cord-014516-r59usk02 2684 7 count count NN cord-014516-r59usk02 2684 8 ( ( -LRB- cord-014516-r59usk02 2684 9 p p NN cord-014516-r59usk02 2684 10 = = SYM cord-014516-r59usk02 2684 11 0.0001 0.0001 CD cord-014516-r59usk02 2684 12 ) ) -RRB- cord-014516-r59usk02 2684 13 and and CC cord-014516-r59usk02 2684 14 neutrophils neutrophil NNS cord-014516-r59usk02 2684 15 increasing increase VBG cord-014516-r59usk02 2684 16 ( ( -LRB- cord-014516-r59usk02 2684 17 p p NN cord-014516-r59usk02 2684 18 = = SYM cord-014516-r59usk02 2684 19 0.0001 0.0001 CD cord-014516-r59usk02 2684 20 ) ) -RRB- cord-014516-r59usk02 2684 21 , , , cord-014516-r59usk02 2684 22 while while IN cord-014516-r59usk02 2684 23 tends tend VBZ cord-014516-r59usk02 2684 24 to to TO cord-014516-r59usk02 2684 25 decrease decrease VB cord-014516-r59usk02 2684 26 with with IN cord-014516-r59usk02 2684 27 lymphocytes lymphocyte NNS cord-014516-r59usk02 2684 28 increasing increase VBG cord-014516-r59usk02 2684 29 ( ( -LRB- cord-014516-r59usk02 2684 30 p p NN cord-014516-r59usk02 2684 31 = = SYM cord-014516-r59usk02 2684 32 0.008 0.008 CD cord-014516-r59usk02 2684 33 ) ) -RRB- cord-014516-r59usk02 2684 34 . . . cord-014516-r59usk02 2685 1 Furthermore furthermore RB cord-014516-r59usk02 2685 2 , , , cord-014516-r59usk02 2685 3 UPC UPC NNP cord-014516-r59usk02 2685 4 significantly significantly RB cord-014516-r59usk02 2685 5 increases increase VBZ cord-014516-r59usk02 2685 6 in in IN cord-014516-r59usk02 2685 7 presence presence NN cord-014516-r59usk02 2685 8 of of IN cord-014516-r59usk02 2685 9 an an DT cord-014516-r59usk02 2685 10 inflammatory inflammatory JJ cord-014516-r59usk02 2685 11 serum serum NN cord-014516-r59usk02 2685 12 protein protein NN cord-014516-r59usk02 2685 13 electrophoretic electrophoretic JJ cord-014516-r59usk02 2685 14 pattern pattern NN cord-014516-r59usk02 2685 15 . . . cord-014516-r59usk02 2686 1 UPC UPC NNP cord-014516-r59usk02 2686 2 tends tend VBZ cord-014516-r59usk02 2686 3 to to TO cord-014516-r59usk02 2686 4 increase increase VB cord-014516-r59usk02 2686 5 with with IN cord-014516-r59usk02 2686 6 phosphorus phosphorus NN cord-014516-r59usk02 2686 7 and and CC cord-014516-r59usk02 2686 8 ALP ALP NNP cord-014516-r59usk02 2686 9 increasing increase VBG cord-014516-r59usk02 2686 10 ( ( -LRB- cord-014516-r59usk02 2686 11 p p NN cord-014516-r59usk02 2686 12 < < XX cord-014516-r59usk02 2686 13 0.0001 0.0001 CD cord-014516-r59usk02 2686 14 and and CC cord-014516-r59usk02 2686 15 p p NN cord-014516-r59usk02 2686 16 = = SYM cord-014516-r59usk02 2686 17 0.0005 0.0005 CD cord-014516-r59usk02 2686 18 respectively respectively RB cord-014516-r59usk02 2686 19 ) ) -RRB- cord-014516-r59usk02 2686 20 ; ; : cord-014516-r59usk02 2686 21 while while IN cord-014516-r59usk02 2686 22 the the DT cord-014516-r59usk02 2686 23 role role NN cord-014516-r59usk02 2686 24 of of IN cord-014516-r59usk02 2686 25 phosphorus phosphorus NN cord-014516-r59usk02 2686 26 in in IN cord-014516-r59usk02 2686 27 CKD CKD NNP cord-014516-r59usk02 2686 28 is be VBZ cord-014516-r59usk02 2686 29 well well RB cord-014516-r59usk02 2686 30 known know VBN cord-014516-r59usk02 2686 31 , , , cord-014516-r59usk02 2686 32 the the DT cord-014516-r59usk02 2686 33 increase increase NN cord-014516-r59usk02 2686 34 of of IN cord-014516-r59usk02 2686 35 ALP ALP NNP cord-014516-r59usk02 2686 36 is be VBZ cord-014516-r59usk02 2686 37 questionable questionable JJ cord-014516-r59usk02 2686 38 : : : cord-014516-r59usk02 2686 39 it -PRON- PRP cord-014516-r59usk02 2686 40 has have VBZ cord-014516-r59usk02 2686 41 been be VBN cord-014516-r59usk02 2686 42 hypothesized hypothesize VBN cord-014516-r59usk02 2686 43 that that IN cord-014516-r59usk02 2686 44 higher high JJR cord-014516-r59usk02 2686 45 ALP ALP NNP cord-014516-r59usk02 2686 46 levels level NNS cord-014516-r59usk02 2686 47 in in IN cord-014516-r59usk02 2686 48 CKD CKD NNP cord-014516-r59usk02 2686 49 could could MD cord-014516-r59usk02 2686 50 be be VB cord-014516-r59usk02 2686 51 related relate VBN cord-014516-r59usk02 2686 52 to to IN cord-014516-r59usk02 2686 53 B B NNP cord-014516-r59usk02 2686 54 - - HYPH cord-014516-r59usk02 2686 55 ALP ALP NNP cord-014516-r59usk02 2686 56 increase increase NN cord-014516-r59usk02 2686 57 due due JJ cord-014516-r59usk02 2686 58 to to IN cord-014516-r59usk02 2686 59 bone bone NN cord-014516-r59usk02 2686 60 remodelling remodelling NN cord-014516-r59usk02 2686 61 in in IN cord-014516-r59usk02 2686 62 secondary secondary JJ cord-014516-r59usk02 2686 63 renal renal JJ cord-014516-r59usk02 2686 64 hyperparathyroidism hyperparathyroidism NN cord-014516-r59usk02 2686 65 . . . cord-014516-r59usk02 2687 1 Considering consider VBG cord-014516-r59usk02 2687 2 urine urine NN cord-014516-r59usk02 2687 3 parameters parameter NNS cord-014516-r59usk02 2687 4 , , , cord-014516-r59usk02 2687 5 UPC UPC NNP cord-014516-r59usk02 2687 6 increases increase VBZ cord-014516-r59usk02 2687 7 when when WRB cord-014516-r59usk02 2687 8 urinary urinary JJ cord-014516-r59usk02 2687 9 specific specific JJ cord-014516-r59usk02 2687 10 gravity gravity NN cord-014516-r59usk02 2687 11 and and CC cord-014516-r59usk02 2687 12 pH ph NN cord-014516-r59usk02 2687 13 decrease decrease NN cord-014516-r59usk02 2687 14 ( ( -LRB- cord-014516-r59usk02 2687 15 probably probably RB cord-014516-r59usk02 2687 16 related relate VBN cord-014516-r59usk02 2687 17 to to IN cord-014516-r59usk02 2687 18 worsening worsen VBG cord-014516-r59usk02 2687 19 of of IN cord-014516-r59usk02 2687 20 CKD CKD NNP cord-014516-r59usk02 2687 21 and and CC cord-014516-r59usk02 2687 22 development development NN cord-014516-r59usk02 2687 23 of of IN cord-014516-r59usk02 2687 24 a a DT cord-014516-r59usk02 2687 25 metabolic metabolic JJ cord-014516-r59usk02 2687 26 acidosis acidosis NN cord-014516-r59usk02 2687 27 ) ) -RRB- cord-014516-r59usk02 2687 28 and and CC cord-014516-r59usk02 2687 29 when when WRB cord-014516-r59usk02 2687 30 glicosuria glicosuria NNP cord-014516-r59usk02 2687 31 is be VBZ cord-014516-r59usk02 2687 32 present present JJ cord-014516-r59usk02 2687 33 , , , cord-014516-r59usk02 2687 34 regardless regardless RB cord-014516-r59usk02 2687 35 of of IN cord-014516-r59usk02 2687 36 the the DT cord-014516-r59usk02 2687 37 cause cause NN cord-014516-r59usk02 2687 38 . . . cord-014516-r59usk02 2688 1 Furthermore furthermore RB cord-014516-r59usk02 2688 2 , , , cord-014516-r59usk02 2688 3 proteinuria proteinuria NN cord-014516-r59usk02 2688 4 increases increase NNS cord-014516-r59usk02 2688 5 in in IN cord-014516-r59usk02 2688 6 presence presence NN cord-014516-r59usk02 2688 7 of of IN cord-014516-r59usk02 2688 8 RBC RBC NNP cord-014516-r59usk02 2688 9 in in IN cord-014516-r59usk02 2688 10 urinary urinary JJ cord-014516-r59usk02 2688 11 sediment sediment NN cord-014516-r59usk02 2688 12 and and CC cord-014516-r59usk02 2688 13 in in IN cord-014516-r59usk02 2688 14 samples sample NNS cord-014516-r59usk02 2688 15 where where WRB cord-014516-r59usk02 2688 16 casts cast NNS cord-014516-r59usk02 2688 17 were be VBD cord-014516-r59usk02 2688 18 observed observe VBN cord-014516-r59usk02 2688 19 , , , cord-014516-r59usk02 2688 20 in in IN cord-014516-r59usk02 2688 21 particularly particularly RB cord-014516-r59usk02 2688 22 when when WRB cord-014516-r59usk02 2688 23 RBC RBC NNP cord-014516-r59usk02 2688 24 casts cast VBZ cord-014516-r59usk02 2688 25 ( ( -LRB- cord-014516-r59usk02 2688 26 considered consider VBN cord-014516-r59usk02 2688 27 always always RB cord-014516-r59usk02 2688 28 pathological pathological JJ cord-014516-r59usk02 2688 29 and and CC cord-014516-r59usk02 2688 30 indicative indicative JJ cord-014516-r59usk02 2688 31 of of IN cord-014516-r59usk02 2688 32 glomerular glomerular JJ cord-014516-r59usk02 2688 33 damage damage NN cord-014516-r59usk02 2688 34 ) ) -RRB- cord-014516-r59usk02 2688 35 were be VBD cord-014516-r59usk02 2688 36 present present JJ cord-014516-r59usk02 2688 37 . . . cord-014516-r59usk02 2689 1 UPC UPC NNP cord-014516-r59usk02 2689 2 values value NNS cord-014516-r59usk02 2689 3 assessed assess VBN cord-014516-r59usk02 2689 4 in in IN cord-014516-r59usk02 2689 5 proteinuric proteinuric JJ cord-014516-r59usk02 2689 6 cats cat NNS cord-014516-r59usk02 2689 7 and and CC cord-014516-r59usk02 2689 8 data datum NNS cord-014516-r59usk02 2689 9 analysis analysis NN cord-014516-r59usk02 2689 10 suggest suggest VBP cord-014516-r59usk02 2689 11 the the DT cord-014516-r59usk02 2689 12 need need NN cord-014516-r59usk02 2689 13 of of TO cord-014516-r59usk02 2689 14 deepen deepen VB cord-014516-r59usk02 2689 15 the the DT cord-014516-r59usk02 2689 16 analytical analytical JJ cord-014516-r59usk02 2689 17 variability variability NN cord-014516-r59usk02 2689 18 of of IN cord-014516-r59usk02 2689 19 UPC UPC NNP cord-014516-r59usk02 2689 20 and and CC cord-014516-r59usk02 2689 21 the the DT cord-014516-r59usk02 2689 22 opportunity opportunity NN cord-014516-r59usk02 2689 23 to to TO cord-014516-r59usk02 2689 24 reconsider reconsider VB cord-014516-r59usk02 2689 25 the the DT cord-014516-r59usk02 2689 26 intervals interval NNS cord-014516-r59usk02 2689 27 of of IN cord-014516-r59usk02 2689 28 substaging substaging NN cord-014516-r59usk02 2689 29 by by IN cord-014516-r59usk02 2689 30 proteinuria proteinuria NN cord-014516-r59usk02 2689 31 in in IN cord-014516-r59usk02 2689 32 cats cat NNS cord-014516-r59usk02 2689 33 . . . cord-014516-r59usk02 2690 1 No no DT cord-014516-r59usk02 2690 2 conflicts conflict NNS cord-014516-r59usk02 2690 3 of of IN cord-014516-r59usk02 2690 4 interest interest NN cord-014516-r59usk02 2690 5 reported report VBN cord-014516-r59usk02 2690 6 . . . cord-014516-r59usk02 2691 1 The the DT cord-014516-r59usk02 2691 2 aim aim NN cord-014516-r59usk02 2691 3 of of IN cord-014516-r59usk02 2691 4 this this DT cord-014516-r59usk02 2691 5 retrospective retrospective JJ cord-014516-r59usk02 2691 6 study study NN cord-014516-r59usk02 2691 7 was be VBD cord-014516-r59usk02 2691 8 to to TO cord-014516-r59usk02 2691 9 evaluate evaluate VB cord-014516-r59usk02 2691 10 : : : cord-014516-r59usk02 2691 11 a a LS cord-014516-r59usk02 2691 12 ) ) -RRB- cord-014516-r59usk02 2692 1 the the DT cord-014516-r59usk02 2692 2 relations relation NNS cord-014516-r59usk02 2692 3 between between IN cord-014516-r59usk02 2692 4 urine urine NN cord-014516-r59usk02 2692 5 culture culture NN cord-014516-r59usk02 2692 6 results result NNS cord-014516-r59usk02 2692 7 and and CC cord-014516-r59usk02 2692 8 urinalysis urinalysis NN cord-014516-r59usk02 2692 9 parameters parameter NNS cord-014516-r59usk02 2692 10 ; ; : cord-014516-r59usk02 2692 11 b b LS cord-014516-r59usk02 2692 12 ) ) -RRB- cord-014516-r59usk02 2692 13 the the DT cord-014516-r59usk02 2692 14 results result NNS cord-014516-r59usk02 2692 15 of of IN cord-014516-r59usk02 2692 16 the the DT cord-014516-r59usk02 2692 17 antimicrobial antimicrobial JJ cord-014516-r59usk02 2692 18 susceptibility susceptibility NN cord-014516-r59usk02 2692 19 tests test NNS cord-014516-r59usk02 2692 20 . . . cord-014516-r59usk02 2693 1 Urine urine NN cord-014516-r59usk02 2693 2 samples sample NNS cord-014516-r59usk02 2693 3 were be VBD cord-014516-r59usk02 2693 4 collected collect VBN cord-014516-r59usk02 2693 5 by by IN cord-014516-r59usk02 2693 6 cystocentesis cystocentesis NN cord-014516-r59usk02 2693 7 from from IN cord-014516-r59usk02 2693 8 252 252 CD cord-014516-r59usk02 2693 9 dogs dog NNS cord-014516-r59usk02 2693 10 and and CC cord-014516-r59usk02 2693 11 52 52 CD cord-014516-r59usk02 2693 12 cats cat NNS cord-014516-r59usk02 2693 13 , , , cord-014516-r59usk02 2693 14 whose whose WP$ cord-014516-r59usk02 2693 15 diagnostic diagnostic JJ cord-014516-r59usk02 2693 16 workup workup NN cord-014516-r59usk02 2693 17 included include VBD cord-014516-r59usk02 2693 18 a a DT cord-014516-r59usk02 2693 19 differential differential JJ cord-014516-r59usk02 2693 20 diagnosis diagnosis NN cord-014516-r59usk02 2693 21 of of IN cord-014516-r59usk02 2693 22 UTI UTI NNP cord-014516-r59usk02 2693 23 : : : cord-014516-r59usk02 2693 24 all all DT cord-014516-r59usk02 2693 25 samples sample NNS cord-014516-r59usk02 2693 26 underwent undergo VBD cord-014516-r59usk02 2693 27 a a DT cord-014516-r59usk02 2693 28 complete complete JJ cord-014516-r59usk02 2693 29 urinalysis urinalysis NN cord-014516-r59usk02 2693 30 , , , cord-014516-r59usk02 2693 31 UPC UPC NNP cord-014516-r59usk02 2693 32 ratio ratio NN cord-014516-r59usk02 2693 33 assessment assessment NN cord-014516-r59usk02 2693 34 and and CC cord-014516-r59usk02 2693 35 urine urine NN cord-014516-r59usk02 2693 36 culture culture NN cord-014516-r59usk02 2693 37 . . . cord-014516-r59usk02 2694 1 Infected infect VBN cord-014516-r59usk02 2694 2 vs vs IN cord-014516-r59usk02 2694 3 sterile sterile JJ cord-014516-r59usk02 2694 4 results result NNS cord-014516-r59usk02 2694 5 were be VBD cord-014516-r59usk02 2694 6 related relate VBN cord-014516-r59usk02 2694 7 to to IN cord-014516-r59usk02 2694 8 urine urine NN cord-014516-r59usk02 2694 9 physical physical JJ cord-014516-r59usk02 2694 10 , , , cord-014516-r59usk02 2694 11 chemical chemical NN cord-014516-r59usk02 2694 12 parameters parameter NNS cord-014516-r59usk02 2694 13 and and CC cord-014516-r59usk02 2694 14 observations observation NNS cord-014516-r59usk02 2694 15 from from IN cord-014516-r59usk02 2694 16 urinary urinary JJ cord-014516-r59usk02 2694 17 sediment sediment NN cord-014516-r59usk02 2694 18 analysis analysis NN cord-014516-r59usk02 2694 19 . . . cord-014516-r59usk02 2695 1 Statistical statistical JJ cord-014516-r59usk02 2695 2 analysis analysis NN cord-014516-r59usk02 2695 3 was be VBD cord-014516-r59usk02 2695 4 performed perform VBN cord-014516-r59usk02 2695 5 using use VBG cord-014516-r59usk02 2695 6 JMP JMP NNP cord-014516-r59usk02 2695 7 7.0 7.0 NNP cord-014516-r59usk02 2695 8 ( ( -LRB- cord-014516-r59usk02 2695 9 SAS SAS NNP cord-014516-r59usk02 2695 10 Institute Institute NNP cord-014516-r59usk02 2695 11 Inc. Inc. NNP cord-014516-r59usk02 2695 12 ) ) -RRB- cord-014516-r59usk02 2695 13 . . . cord-014516-r59usk02 2696 1 A a DT cord-014516-r59usk02 2696 2 p p NN cord-014516-r59usk02 2696 3 value value NN cord-014516-r59usk02 2696 4 < < XX cord-014516-r59usk02 2696 5 0,05 0,05 NNP cord-014516-r59usk02 2696 6 was be VBD cord-014516-r59usk02 2696 7 considered consider VBN cord-014516-r59usk02 2696 8 significant significant JJ cord-014516-r59usk02 2696 9 . . . cord-014516-r59usk02 2697 1 Urine urine NN cord-014516-r59usk02 2697 2 culture culture NN cord-014516-r59usk02 2697 3 resulted result VBD cord-014516-r59usk02 2697 4 positive positive JJ cord-014516-r59usk02 2697 5 in in IN cord-014516-r59usk02 2697 6 104 104 CD cord-014516-r59usk02 2697 7 dogs dog NNS cord-014516-r59usk02 2697 8 ( ( -LRB- cord-014516-r59usk02 2697 9 41 41 CD cord-014516-r59usk02 2697 10 % % NN cord-014516-r59usk02 2697 11 ) ) -RRB- cord-014516-r59usk02 2697 12 and and CC cord-014516-r59usk02 2697 13 18 18 CD cord-014516-r59usk02 2697 14 cats cat NNS cord-014516-r59usk02 2697 15 ( ( -LRB- cord-014516-r59usk02 2697 16 33 33 CD cord-014516-r59usk02 2697 17 % % NN cord-014516-r59usk02 2697 18 ) ) -RRB- cord-014516-r59usk02 2697 19 . . . cord-014516-r59usk02 2698 1 The the DT cord-014516-r59usk02 2698 2 presence presence NN cord-014516-r59usk02 2698 3 of of IN cord-014516-r59usk02 2698 4 UTI UTI NNP cord-014516-r59usk02 2698 5 was be VBD cord-014516-r59usk02 2698 6 significantly significantly RB cord-014516-r59usk02 2698 7 related relate VBN cord-014516-r59usk02 2698 8 to to IN cord-014516-r59usk02 2698 9 urine urine NN cord-014516-r59usk02 2698 10 physical physical JJ cord-014516-r59usk02 2698 11 properties property NNS cord-014516-r59usk02 2698 12 ( ( -LRB- cord-014516-r59usk02 2698 13 color color NN cord-014516-r59usk02 2698 14 and and CC cord-014516-r59usk02 2698 15 turbidity turbidity NN cord-014516-r59usk02 2698 16 ) ) -RRB- cord-014516-r59usk02 2698 17 , , , cord-014516-r59usk02 2698 18 USG USG NNP cord-014516-r59usk02 2698 19 and and CC cord-014516-r59usk02 2698 20 leukocyturia leukocyturia NNP cord-014516-r59usk02 2698 21 : : : cord-014516-r59usk02 2698 22 infections infection NNS cord-014516-r59usk02 2698 23 tended tend VBD cord-014516-r59usk02 2698 24 to to TO cord-014516-r59usk02 2698 25 be be VB cord-014516-r59usk02 2698 26 more more RBR cord-014516-r59usk02 2698 27 frequent frequent JJ cord-014516-r59usk02 2698 28 in in IN cord-014516-r59usk02 2698 29 urine urine NN cord-014516-r59usk02 2698 30 samples sample NNS cord-014516-r59usk02 2698 31 characterized characterize VBN cord-014516-r59usk02 2698 32 by by IN cord-014516-r59usk02 2698 33 a a DT cord-014516-r59usk02 2698 34 light light JJ cord-014516-r59usk02 2698 35 yellow yellow JJ cord-014516-r59usk02 2698 36 color color NN cord-014516-r59usk02 2698 37 , , , cord-014516-r59usk02 2698 38 cloudy cloudy JJ cord-014516-r59usk02 2698 39 or or CC cord-014516-r59usk02 2698 40 sub sub JJ cord-014516-r59usk02 2698 41 - - JJ cord-014516-r59usk02 2698 42 limpid limpid JJ cord-014516-r59usk02 2698 43 aspect aspect NN cord-014516-r59usk02 2698 44 and and CC cord-014516-r59usk02 2698 45 low low JJ cord-014516-r59usk02 2698 46 USG usg NN cord-014516-r59usk02 2698 47 . . . cord-014516-r59usk02 2699 1 Nevertheless nevertheless RB cord-014516-r59usk02 2699 2 , , , cord-014516-r59usk02 2699 3 urine urine NN cord-014516-r59usk02 2699 4 was be VBD cord-014516-r59usk02 2699 5 limpid limpid JJ cord-014516-r59usk02 2699 6 in in IN cord-014516-r59usk02 2699 7 30 30 CD cord-014516-r59usk02 2699 8 % % NN cord-014516-r59usk02 2699 9 of of IN cord-014516-r59usk02 2699 10 infected infected JJ cord-014516-r59usk02 2699 11 samples sample NNS cord-014516-r59usk02 2699 12 , , , cord-014516-r59usk02 2699 13 and and CC cord-014516-r59usk02 2699 14 a a DT cord-014516-r59usk02 2699 15 normal normal JJ cord-014516-r59usk02 2699 16 USG usg NN cord-014516-r59usk02 2699 17 was be VBD cord-014516-r59usk02 2699 18 found find VBN cord-014516-r59usk02 2699 19 in in IN cord-014516-r59usk02 2699 20 28.6 28.6 CD cord-014516-r59usk02 2699 21 % % NN cord-014516-r59usk02 2699 22 of of IN cord-014516-r59usk02 2699 23 dog dog NN cord-014516-r59usk02 2699 24 's 's POS cord-014516-r59usk02 2699 25 UTI UTI NNP cord-014516-r59usk02 2699 26 but but CC cord-014516-r59usk02 2699 27 only only RB cord-014516-r59usk02 2699 28 in in IN cord-014516-r59usk02 2699 29 4.8 4.8 CD cord-014516-r59usk02 2699 30 % % NN cord-014516-r59usk02 2699 31 of of IN cord-014516-r59usk02 2699 32 cats cat NNS cord-014516-r59usk02 2699 33 . . . cord-014516-r59usk02 2700 1 Although although IN cord-014516-r59usk02 2700 2 leukocyturia leukocyturia NNP cord-014516-r59usk02 2700 3 tends tend VBZ cord-014516-r59usk02 2700 4 to to TO cord-014516-r59usk02 2700 5 become become VB cord-014516-r59usk02 2700 6 higher high JJR cord-014516-r59usk02 2700 7 in in IN cord-014516-r59usk02 2700 8 infected infected JJ cord-014516-r59usk02 2700 9 samples sample NNS cord-014516-r59usk02 2700 10 both both CC cord-014516-r59usk02 2700 11 in in IN cord-014516-r59usk02 2700 12 dogs dog NNS cord-014516-r59usk02 2700 13 and and CC cord-014516-r59usk02 2700 14 cats cat NNS cord-014516-r59usk02 2700 15 ( ( -LRB- cord-014516-r59usk02 2700 16 p p NN cord-014516-r59usk02 2700 17 < < XX cord-014516-r59usk02 2700 18 0.0001 0.0001 CD cord-014516-r59usk02 2700 19 ) ) -RRB- cord-014516-r59usk02 2700 20 , , , cord-014516-r59usk02 2700 21 in in IN cord-014516-r59usk02 2700 22 23.1 23.1 CD cord-014516-r59usk02 2700 23 % % NN cord-014516-r59usk02 2700 24 of of IN cord-014516-r59usk02 2700 25 infected infected JJ cord-014516-r59usk02 2700 26 sediments sediment NNS cord-014516-r59usk02 2700 27 WBC WBC NNP cord-014516-r59usk02 2700 28 count count NN cord-014516-r59usk02 2700 29 was be VBD cord-014516-r59usk02 2700 30 normal normal JJ cord-014516-r59usk02 2700 31 . . . cord-014516-r59usk02 2701 1 Haematuria Haematuria NNP cord-014516-r59usk02 2701 2 detected detect VBN cord-014516-r59usk02 2701 3 by by IN cord-014516-r59usk02 2701 4 dipstick dipstick NNP cord-014516-r59usk02 2701 5 was be VBD cord-014516-r59usk02 2701 6 significantly significantly RB cord-014516-r59usk02 2701 7 related relate VBN cord-014516-r59usk02 2701 8 to to IN cord-014516-r59usk02 2701 9 UTI UTI NNP cord-014516-r59usk02 2701 10 in in IN cord-014516-r59usk02 2701 11 dogs dog NNS cord-014516-r59usk02 2701 12 but but CC cord-014516-r59usk02 2701 13 not not RB cord-014516-r59usk02 2701 14 in in IN cord-014516-r59usk02 2701 15 cats cat NNS cord-014516-r59usk02 2702 1 , , , cord-014516-r59usk02 2702 2 nevertheless nevertheless RB cord-014516-r59usk02 2702 3 the the DT cord-014516-r59usk02 2702 4 RBC RBC NNP cord-014516-r59usk02 2702 5 count count NN cord-014516-r59usk02 2702 6 in in IN cord-014516-r59usk02 2702 7 sediment sediment NN cord-014516-r59usk02 2702 8 was be VBD cord-014516-r59usk02 2702 9 not not RB cord-014516-r59usk02 2702 10 related relate VBN cord-014516-r59usk02 2702 11 to to IN cord-014516-r59usk02 2702 12 infection infection NN cord-014516-r59usk02 2702 13 in in IN cord-014516-r59usk02 2702 14 both both DT cord-014516-r59usk02 2702 15 species specie NNS cord-014516-r59usk02 2702 16 : : : cord-014516-r59usk02 2702 17 RBC RBC NNP cord-014516-r59usk02 2702 18 count count NN cord-014516-r59usk02 2702 19 was be VBD cord-014516-r59usk02 2702 20 normal normal JJ cord-014516-r59usk02 2702 21 in in IN cord-014516-r59usk02 2702 22 30.4 30.4 CD cord-014516-r59usk02 2702 23 % % NN cord-014516-r59usk02 2702 24 of of IN cord-014516-r59usk02 2702 25 infected infected JJ cord-014516-r59usk02 2702 26 feline feline JJ cord-014516-r59usk02 2702 27 samples sample NNS cord-014516-r59usk02 2702 28 and and CC cord-014516-r59usk02 2702 29 in in IN cord-014516-r59usk02 2702 30 36.4 36.4 CD cord-014516-r59usk02 2702 31 % % NN cord-014516-r59usk02 2702 32 of of IN cord-014516-r59usk02 2702 33 canine canine JJ cord-014516-r59usk02 2702 34 samples sample NNS cord-014516-r59usk02 2702 35 . . . cord-014516-r59usk02 2703 1 No no DT cord-014516-r59usk02 2703 2 significant significant JJ cord-014516-r59usk02 2703 3 relation relation NN cord-014516-r59usk02 2703 4 between between IN cord-014516-r59usk02 2703 5 presence presence NN cord-014516-r59usk02 2703 6 or or CC cord-014516-r59usk02 2703 7 absence absence NN cord-014516-r59usk02 2703 8 of of IN cord-014516-r59usk02 2703 9 UTI UTI NNP cord-014516-r59usk02 2703 10 and and CC cord-014516-r59usk02 2703 11 albuminuria albuminuria NNP cord-014516-r59usk02 2703 12 , , , cord-014516-r59usk02 2703 13 bilirubinuria bilirubinuria NNP cord-014516-r59usk02 2703 14 , , , cord-014516-r59usk02 2703 15 glycosuria glycosuria NNP cord-014516-r59usk02 2703 16 was be VBD cord-014516-r59usk02 2703 17 detected detect VBN cord-014516-r59usk02 2703 18 , , , cord-014516-r59usk02 2703 19 while while IN cord-014516-r59usk02 2703 20 UPC UPC NNP cord-014516-r59usk02 2703 21 tends tend VBZ cord-014516-r59usk02 2703 22 to to TO cord-014516-r59usk02 2703 23 become become VB cord-014516-r59usk02 2703 24 significantly significantly RB cord-014516-r59usk02 2703 25 higher high JJR cord-014516-r59usk02 2703 26 in in IN cord-014516-r59usk02 2703 27 dogs dog NNS cord-014516-r59usk02 2703 28 . . . cord-014516-r59usk02 2704 1 Although although IN cord-014516-r59usk02 2704 2 the the DT cord-014516-r59usk02 2704 3 chi chi JJ cord-014516-r59usk02 2704 4 - - HYPH cord-014516-r59usk02 2704 5 square square JJ cord-014516-r59usk02 2704 6 test test NN cord-014516-r59usk02 2704 7 showed show VBD cord-014516-r59usk02 2704 8 a a DT cord-014516-r59usk02 2704 9 significant significant JJ cord-014516-r59usk02 2704 10 relation relation NN cord-014516-r59usk02 2704 11 between between IN cord-014516-r59usk02 2704 12 infection infection NN cord-014516-r59usk02 2704 13 and and CC cord-014516-r59usk02 2704 14 the the DT cord-014516-r59usk02 2704 15 detection detection NN cord-014516-r59usk02 2704 16 of of IN cord-014516-r59usk02 2704 17 bacteria bacteria NNS cord-014516-r59usk02 2704 18 in in IN cord-014516-r59usk02 2704 19 urinary urinary JJ cord-014516-r59usk02 2704 20 sediment sediment NN cord-014516-r59usk02 2704 21 , , , cord-014516-r59usk02 2704 22 a a DT cord-014516-r59usk02 2704 23 pseudobacteriuria pseudobacteriuria NN cord-014516-r59usk02 2704 24 was be VBD cord-014516-r59usk02 2704 25 found find VBN cord-014516-r59usk02 2704 26 in in IN cord-014516-r59usk02 2704 27 20.5 20.5 CD cord-014516-r59usk02 2704 28 % % NN cord-014516-r59usk02 2704 29 of of IN cord-014516-r59usk02 2704 30 samples sample NNS cord-014516-r59usk02 2704 31 ; ; : cord-014516-r59usk02 2704 32 furthermore furthermore RB cord-014516-r59usk02 2704 33 bacteria bacteria NNS cord-014516-r59usk02 2704 34 were be VBD cord-014516-r59usk02 2704 35 n't not RB cord-014516-r59usk02 2704 36 observed observe VBN cord-014516-r59usk02 2704 37 in in IN cord-014516-r59usk02 2704 38 25.1 25.1 CD cord-014516-r59usk02 2704 39 % % NN cord-014516-r59usk02 2704 40 of of IN cord-014516-r59usk02 2704 41 infected infected JJ cord-014516-r59usk02 2704 42 samples sample NNS cord-014516-r59usk02 2704 43 ( ( -LRB- cord-014516-r59usk02 2704 44 USG<1.013 USG<1.013 NNP cord-014516-r59usk02 2704 45 ) ) -RRB- cord-014516-r59usk02 2704 46 . . . cord-014516-r59usk02 2705 1 E. E. NNP cord-014516-r59usk02 2705 2 coli coli NNS cord-014516-r59usk02 2705 3 was be VBD cord-014516-r59usk02 2705 4 isolated isolate VBN cord-014516-r59usk02 2705 5 in in IN cord-014516-r59usk02 2705 6 the the DT cord-014516-r59usk02 2705 7 majority majority NN cord-014516-r59usk02 2705 8 of of IN cord-014516-r59usk02 2705 9 samples sample NNS cord-014516-r59usk02 2705 10 ( ( -LRB- cord-014516-r59usk02 2705 11 45,9 45,9 CD cord-014516-r59usk02 2705 12 % % NN cord-014516-r59usk02 2705 13 ) ) -RRB- cord-014516-r59usk02 2705 14 , , , cord-014516-r59usk02 2705 15 compared compare VBN cord-014516-r59usk02 2705 16 to to IN cord-014516-r59usk02 2705 17 other other JJ cord-014516-r59usk02 2705 18 species specie NNS cord-014516-r59usk02 2705 19 : : : cord-014516-r59usk02 2705 20 Staphylococcus(13.6 staphylococcus(13.6 CD cord-014516-r59usk02 2705 21 % % NN cord-014516-r59usk02 2705 22 ) ) -RRB- cord-014516-r59usk02 2705 23 , , , cord-014516-r59usk02 2705 24 Proteus Proteus NNP cord-014516-r59usk02 2705 25 ( ( -LRB- cord-014516-r59usk02 2705 26 10.2 10.2 CD cord-014516-r59usk02 2705 27 % % NN cord-014516-r59usk02 2705 28 ) ) -RRB- cord-014516-r59usk02 2705 29 and and CC cord-014516-r59usk02 2705 30 Streptococcus streptococcus NN cord-014516-r59usk02 2705 31 . . . cord-014516-r59usk02 2706 1 ( ( -LRB- cord-014516-r59usk02 2706 2 8.5 8.5 CD cord-014516-r59usk02 2706 3 % % NN cord-014516-r59usk02 2706 4 ) ) -RRB- cord-014516-r59usk02 2706 5 . . . cord-014516-r59usk02 2707 1 The the DT cord-014516-r59usk02 2707 2 urinalysis urinalysis NN cord-014516-r59usk02 2707 3 pitfalls pitfall NNS cord-014516-r59usk02 2707 4 and and CC cord-014516-r59usk02 2707 5 the the DT cord-014516-r59usk02 2707 6 high high JJ cord-014516-r59usk02 2707 7 antibiotic antibiotic JJ cord-014516-r59usk02 2707 8 resistance resistance NN cord-014516-r59usk02 2707 9 verified verify VBN cord-014516-r59usk02 2707 10 towards towards IN cord-014516-r59usk02 2707 11 the the DT cord-014516-r59usk02 2707 12 most most RBS cord-014516-r59usk02 2707 13 widely widely RB cord-014516-r59usk02 2707 14 used use VBN cord-014516-r59usk02 2707 15 molecules molecule NNS cord-014516-r59usk02 2707 16 ( ( -LRB- cord-014516-r59usk02 2707 17 penicillins penicillin NNS cord-014516-r59usk02 2707 18 , , , cord-014516-r59usk02 2707 19 cephalosporins cephalosporin NNS cord-014516-r59usk02 2707 20 , , , cord-014516-r59usk02 2707 21 quinolones quinolones NNP cord-014516-r59usk02 2707 22 ) ) -RRB- cord-014516-r59usk02 2707 23 strongly strongly RB cord-014516-r59usk02 2707 24 indicates indicate VBZ cord-014516-r59usk02 2707 25 the the DT cord-014516-r59usk02 2707 26 importance importance NN cord-014516-r59usk02 2707 27 to to TO cord-014516-r59usk02 2707 28 perform perform VB cord-014516-r59usk02 2707 29 antimicrobials antimicrobial NNS cord-014516-r59usk02 2707 30 susceptibility susceptibility NN cord-014516-r59usk02 2707 31 tests test NNS cord-014516-r59usk02 2707 32 to to TO cord-014516-r59usk02 2707 33 avoid avoid VB cord-014516-r59usk02 2707 34 the the DT cord-014516-r59usk02 2707 35 risk risk NN cord-014516-r59usk02 2707 36 of of IN cord-014516-r59usk02 2707 37 failure failure NN cord-014516-r59usk02 2707 38 associated associate VBN cord-014516-r59usk02 2707 39 with with IN cord-014516-r59usk02 2707 40 the the DT cord-014516-r59usk02 2707 41 use use NN cord-014516-r59usk02 2707 42 or or CC cord-014516-r59usk02 2707 43 abuse abuse NN cord-014516-r59usk02 2707 44 of of IN cord-014516-r59usk02 2707 45 empiric empiric JJ cord-014516-r59usk02 2707 46 therapies therapy NNS cord-014516-r59usk02 2707 47 in in IN cord-014516-r59usk02 2707 48 UTIs uti NNS cord-014516-r59usk02 2707 49 . . . cord-014516-r59usk02 2708 1 No no DT cord-014516-r59usk02 2708 2 conflicts conflict NNS cord-014516-r59usk02 2708 3 of of IN cord-014516-r59usk02 2708 4 interest interest NN cord-014516-r59usk02 2708 5 reported report VBN cord-014516-r59usk02 2708 6 . . . cord-014516-r59usk02 2709 1 Azotemia azotemia NN cord-014516-r59usk02 2709 2 in in IN cord-014516-r59usk02 2709 3 dogs dog NNS cord-014516-r59usk02 2709 4 with with IN cord-014516-r59usk02 2709 5 chronic chronic JJ cord-014516-r59usk02 2709 6 heart heart NN cord-014516-r59usk02 2709 7 failure failure NN cord-014516-r59usk02 2709 8 may may MD cord-014516-r59usk02 2709 9 reflect reflect VB cord-014516-r59usk02 2709 10 impaired impaired JJ cord-014516-r59usk02 2709 11 renal renal JJ cord-014516-r59usk02 2709 12 function function NN cord-014516-r59usk02 2709 13 not not RB cord-014516-r59usk02 2709 14 only only RB cord-014516-r59usk02 2709 15 because because IN cord-014516-r59usk02 2709 16 of of IN cord-014516-r59usk02 2709 17 inadequate inadequate JJ cord-014516-r59usk02 2709 18 renal renal JJ cord-014516-r59usk02 2709 19 perfusion perfusion NN cord-014516-r59usk02 2709 20 , , , cord-014516-r59usk02 2709 21 but but CC cord-014516-r59usk02 2709 22 also also RB cord-014516-r59usk02 2709 23 due due JJ cord-014516-r59usk02 2709 24 to to IN cord-014516-r59usk02 2709 25 organic organic JJ cord-014516-r59usk02 2709 26 renal renal JJ cord-014516-r59usk02 2709 27 injury injury NN cord-014516-r59usk02 2709 28 . . . cord-014516-r59usk02 2710 1 Impaired impaired JJ cord-014516-r59usk02 2710 2 renal renal JJ cord-014516-r59usk02 2710 3 function function NN cord-014516-r59usk02 2710 4 is be VBZ cord-014516-r59usk02 2710 5 observed observe VBN cord-014516-r59usk02 2710 6 in in IN cord-014516-r59usk02 2710 7 50 50 CD cord-014516-r59usk02 2710 8 % % NN cord-014516-r59usk02 2710 9 of of IN cord-014516-r59usk02 2710 10 dogs dog NNS cord-014516-r59usk02 2710 11 with with IN cord-014516-r59usk02 2710 12 heart heart NN cord-014516-r59usk02 2710 13 failure failure NN cord-014516-r59usk02 2710 14 . . . cord-014516-r59usk02 2711 1 Altered altered JJ cord-014516-r59usk02 2711 2 renal renal JJ cord-014516-r59usk02 2711 3 hemodynamics hemodynamic NNS cord-014516-r59usk02 2711 4 due due JJ cord-014516-r59usk02 2711 5 to to IN cord-014516-r59usk02 2711 6 decreased decrease VBN cord-014516-r59usk02 2711 7 cardiac cardiac JJ cord-014516-r59usk02 2711 8 output output NN cord-014516-r59usk02 2711 9 results result NNS cord-014516-r59usk02 2711 10 in in IN cord-014516-r59usk02 2711 11 renal renal JJ cord-014516-r59usk02 2711 12 hypoperfusion hypoperfusion NN cord-014516-r59usk02 2711 13 , , , cord-014516-r59usk02 2711 14 and and CC cord-014516-r59usk02 2711 15 resultant resultant JJ cord-014516-r59usk02 2711 16 elevation elevation NN cord-014516-r59usk02 2711 17 of of IN cord-014516-r59usk02 2711 18 blood blood NN cord-014516-r59usk02 2711 19 urea urea NN cord-014516-r59usk02 2711 20 nitrogen nitrogen NN cord-014516-r59usk02 2711 21 and and CC cord-014516-r59usk02 2711 22 creatinine creatinine NN cord-014516-r59usk02 2711 23 , , , cord-014516-r59usk02 2711 24 defined define VBN cord-014516-r59usk02 2711 25 as as IN cord-014516-r59usk02 2711 26 azotemia azotemia NN cord-014516-r59usk02 2711 27 . . . cord-014516-r59usk02 2712 1 Azotemia Azotemia NNP cord-014516-r59usk02 2712 2 is be VBZ cord-014516-r59usk02 2712 3 a a DT cord-014516-r59usk02 2712 4 prognostic prognostic JJ cord-014516-r59usk02 2712 5 factor factor NN cord-014516-r59usk02 2712 6 in in IN cord-014516-r59usk02 2712 7 dogs dog NNS cord-014516-r59usk02 2712 8 with with IN cord-014516-r59usk02 2712 9 mitral mitral JJ cord-014516-r59usk02 2712 10 regurgitation regurgitation NN cord-014516-r59usk02 2712 11 , , , cord-014516-r59usk02 2712 12 therefore therefore RB cord-014516-r59usk02 2712 13 , , , cord-014516-r59usk02 2712 14 preservation preservation NN cord-014516-r59usk02 2712 15 and/or and/or CC cord-014516-r59usk02 2712 16 restoration restoration NN cord-014516-r59usk02 2712 17 of of IN cord-014516-r59usk02 2712 18 renal renal JJ cord-014516-r59usk02 2712 19 function function NN cord-014516-r59usk02 2712 20 is be VBZ cord-014516-r59usk02 2712 21 thought think VBN cord-014516-r59usk02 2712 22 to to TO cord-014516-r59usk02 2712 23 improve improve VB cord-014516-r59usk02 2712 24 prognosis prognosis NN cord-014516-r59usk02 2712 25 . . . cord-014516-r59usk02 2713 1 Medical medical JJ cord-014516-r59usk02 2713 2 treatment treatment NN cord-014516-r59usk02 2713 3 for for IN cord-014516-r59usk02 2713 4 heart heart NN cord-014516-r59usk02 2713 5 failure failure NN cord-014516-r59usk02 2713 6 , , , cord-014516-r59usk02 2713 7 however however RB cord-014516-r59usk02 2713 8 , , , cord-014516-r59usk02 2713 9 includes include VBZ cord-014516-r59usk02 2713 10 angiotensin angiotensin NN cord-014516-r59usk02 2713 11 converting convert VBG cord-014516-r59usk02 2713 12 enzyme enzyme NN cord-014516-r59usk02 2713 13 inhibitors inhibitor NNS cord-014516-r59usk02 2713 14 and and CC cord-014516-r59usk02 2713 15 loop loop NN cord-014516-r59usk02 2713 16 diuretics diuretic NNS cord-014516-r59usk02 2713 17 , , , cord-014516-r59usk02 2713 18 which which WDT cord-014516-r59usk02 2713 19 has have VBZ cord-014516-r59usk02 2713 20 been be VBN cord-014516-r59usk02 2713 21 shown show VBN cord-014516-r59usk02 2713 22 to to TO cord-014516-r59usk02 2713 23 increase increase VB cord-014516-r59usk02 2713 24 the the DT cord-014516-r59usk02 2713 25 risk risk NN cord-014516-r59usk02 2713 26 of of IN cord-014516-r59usk02 2713 27 developing develop VBG cord-014516-r59usk02 2713 28 azotemia azotemia NN cord-014516-r59usk02 2713 29 . . . cord-014516-r59usk02 2714 1 We -PRON- PRP cord-014516-r59usk02 2714 2 hypothesized hypothesize VBD cord-014516-r59usk02 2714 3 that that IN cord-014516-r59usk02 2714 4 mitral mitral JJ cord-014516-r59usk02 2714 5 valve valve NN cord-014516-r59usk02 2714 6 repair repair NN cord-014516-r59usk02 2714 7 surgery surgery NN cord-014516-r59usk02 2714 8 ameliorates ameliorate VBZ cord-014516-r59usk02 2714 9 renal renal JJ cord-014516-r59usk02 2714 10 function function NN cord-014516-r59usk02 2714 11 by by IN cord-014516-r59usk02 2714 12 improvement improvement NN cord-014516-r59usk02 2714 13 of of IN cord-014516-r59usk02 2714 14 systemic systemic JJ cord-014516-r59usk02 2714 15 hemodynamics hemodynamic NNS cord-014516-r59usk02 2714 16 . . . cord-014516-r59usk02 2715 1 The the DT cord-014516-r59usk02 2715 2 change change NN cord-014516-r59usk02 2715 3 in in IN cord-014516-r59usk02 2715 4 renal renal JJ cord-014516-r59usk02 2715 5 function function NN cord-014516-r59usk02 2715 6 in in IN cord-014516-r59usk02 2715 7 dogs dog NNS cord-014516-r59usk02 2715 8 with with IN cord-014516-r59usk02 2715 9 mitral mitral JJ cord-014516-r59usk02 2715 10 regurgitation regurgitation NN cord-014516-r59usk02 2715 11 was be VBD cord-014516-r59usk02 2715 12 assessed assess VBN cord-014516-r59usk02 2715 13 by by IN cord-014516-r59usk02 2715 14 evaluating evaluate VBG cord-014516-r59usk02 2715 15 time time NN cord-014516-r59usk02 2715 16 - - HYPH cord-014516-r59usk02 2715 17 dependent dependent JJ cord-014516-r59usk02 2715 18 changes change NNS cord-014516-r59usk02 2715 19 in in IN cord-014516-r59usk02 2715 20 glomelular glomelular NNP cord-014516-r59usk02 2715 21 filtration filtration NN cord-014516-r59usk02 2715 22 rate rate NN cord-014516-r59usk02 2715 23 by by IN cord-014516-r59usk02 2715 24 inulin inulin NN cord-014516-r59usk02 2715 25 clearance clearance NN cord-014516-r59usk02 2715 26 before before IN cord-014516-r59usk02 2715 27 and and CC cord-014516-r59usk02 2715 28 after after IN cord-014516-r59usk02 2715 29 cardiac cardiac JJ cord-014516-r59usk02 2715 30 surgery surgery NN cord-014516-r59usk02 2715 31 . . . cord-014516-r59usk02 2716 1 Eighteen eighteen CD cord-014516-r59usk02 2716 2 dogs dog NNS cord-014516-r59usk02 2716 3 with with IN cord-014516-r59usk02 2716 4 severe severe JJ cord-014516-r59usk02 2716 5 mitral mitral JJ cord-014516-r59usk02 2716 6 regurgitation regurgitation NN cord-014516-r59usk02 2716 7 with with IN cord-014516-r59usk02 2716 8 azotemia azotemia NN cord-014516-r59usk02 2716 9 ( ( -LRB- cord-014516-r59usk02 2716 10 plasma plasma NN cord-014516-r59usk02 2716 11 urea urea NN cord-014516-r59usk02 2716 12 nitrogen nitrogen NN cord-014516-r59usk02 2716 13 level level NN cord-014516-r59usk02 2716 14 > > XX cord-014516-r59usk02 2717 1 28 28 CD cord-014516-r59usk02 2717 2 mg mg NNP cord-014516-r59usk02 2717 3 / / SYM cord-014516-r59usk02 2717 4 dL dl NN cord-014516-r59usk02 2718 1 , , , cord-014516-r59usk02 2718 2 plasma plasma NN cord-014516-r59usk02 2718 3 creatinine creatinine NN cord-014516-r59usk02 2718 4 level level NN cord-014516-r59usk02 2718 5 > > XX cord-014516-r59usk02 2719 1 1.9 1.9 CD cord-014516-r59usk02 2719 2 mg mg NNP cord-014516-r59usk02 2719 3 / / SYM cord-014516-r59usk02 2719 4 dL dl NN cord-014516-r59usk02 2719 5 ) ) -RRB- cord-014516-r59usk02 2719 6 were be VBD cord-014516-r59usk02 2719 7 included include VBN cord-014516-r59usk02 2719 8 in in IN cord-014516-r59usk02 2719 9 this this DT cord-014516-r59usk02 2719 10 study study NN cord-014516-r59usk02 2719 11 . . . cord-014516-r59usk02 2720 1 The the DT cord-014516-r59usk02 2720 2 glomerular glomerular JJ cord-014516-r59usk02 2720 3 filtration filtration NN cord-014516-r59usk02 2720 4 rate rate NN cord-014516-r59usk02 2720 5 in in IN cord-014516-r59usk02 2720 6 all all DT cord-014516-r59usk02 2720 7 dogs dog NNS cord-014516-r59usk02 2720 8 were be VBD cord-014516-r59usk02 2720 9 evaluated evaluate VBN cord-014516-r59usk02 2720 10 by by IN cord-014516-r59usk02 2720 11 determining determine VBG cord-014516-r59usk02 2720 12 inulin inulin NN cord-014516-r59usk02 2720 13 clearance clearance NN cord-014516-r59usk02 2720 14 before before IN cord-014516-r59usk02 2720 15 and and CC cord-014516-r59usk02 2720 16 3 3 CD cord-014516-r59usk02 2720 17 months month NNS cord-014516-r59usk02 2720 18 after after IN cord-014516-r59usk02 2720 19 surgery surgery NN cord-014516-r59usk02 2720 20 . . . cord-014516-r59usk02 2721 1 Serum serum NN cord-014516-r59usk02 2721 2 atrial atrial JJ cord-014516-r59usk02 2721 3 natriuretic natriuretic JJ cord-014516-r59usk02 2721 4 peptide peptide NN cord-014516-r59usk02 2721 5 level level NN cord-014516-r59usk02 2721 6 , , , cord-014516-r59usk02 2721 7 plasma plasma NN cord-014516-r59usk02 2721 8 NT NT NNP cord-014516-r59usk02 2721 9 - - HYPH cord-014516-r59usk02 2721 10 pro pro JJ cord-014516-r59usk02 2721 11 brain brain NN cord-014516-r59usk02 2721 12 natriuretic natriuretic JJ cord-014516-r59usk02 2721 13 peptide peptide JJ cord-014516-r59usk02 2721 14 level level NN cord-014516-r59usk02 2721 15 , , , cord-014516-r59usk02 2721 16 plasma plasma NN cord-014516-r59usk02 2721 17 urea urea NN cord-014516-r59usk02 2721 18 nitrogen nitrogen NN cord-014516-r59usk02 2721 19 concentration concentration NN cord-014516-r59usk02 2721 20 , , , cord-014516-r59usk02 2721 21 and and CC cord-014516-r59usk02 2721 22 plasma plasma NN cord-014516-r59usk02 2721 23 creatinine creatinine NN cord-014516-r59usk02 2721 24 concentration concentration NN cord-014516-r59usk02 2721 25 were be VBD cord-014516-r59usk02 2721 26 measured measure VBN cord-014516-r59usk02 2721 27 at at IN cord-014516-r59usk02 2721 28 each each DT cord-014516-r59usk02 2721 29 time time NN cord-014516-r59usk02 2721 30 point point NN cord-014516-r59usk02 2721 31 as as RB cord-014516-r59usk02 2721 32 well well RB cord-014516-r59usk02 2721 33 as as IN cord-014516-r59usk02 2721 34 during during IN cord-014516-r59usk02 2721 35 the the DT cord-014516-r59usk02 2721 36 initial initial JJ cord-014516-r59usk02 2721 37 staging staging NN cord-014516-r59usk02 2721 38 of of IN cord-014516-r59usk02 2721 39 heart heart NN cord-014516-r59usk02 2721 40 failure failure NN cord-014516-r59usk02 2721 41 based base VBN cord-014516-r59usk02 2721 42 on on IN cord-014516-r59usk02 2721 43 the the DT cord-014516-r59usk02 2721 44 International International NNP cord-014516-r59usk02 2721 45 Small Small NNP cord-014516-r59usk02 2721 46 Animal Animal NNP cord-014516-r59usk02 2721 47 Cardiac Cardiac NNP cord-014516-r59usk02 2721 48 Health Health NNP cord-014516-r59usk02 2721 49 Council Council NNP cord-014516-r59usk02 2721 50 ( ( -LRB- cord-014516-r59usk02 2721 51 ISACHC ISACHC NNP cord-014516-r59usk02 2721 52 ) ) -RRB- cord-014516-r59usk02 2721 53 . . . cord-014516-r59usk02 2722 1 Left leave VBN cord-014516-r59usk02 2722 2 atrial atrial JJ cord-014516-r59usk02 2722 3 / / SYM cord-014516-r59usk02 2722 4 aorta aorta NN cord-014516-r59usk02 2722 5 ratio ratio NN cord-014516-r59usk02 2722 6 by by IN cord-014516-r59usk02 2722 7 echocardiography echocardiography NN cord-014516-r59usk02 2722 8 and and CC cord-014516-r59usk02 2722 9 vertebral vertebral JJ cord-014516-r59usk02 2722 10 heart heart NN cord-014516-r59usk02 2722 11 size size NN cord-014516-r59usk02 2722 12 by by IN cord-014516-r59usk02 2722 13 thoracic thoracic JJ cord-014516-r59usk02 2722 14 radiographs radiograph NNS cord-014516-r59usk02 2722 15 were be VBD cord-014516-r59usk02 2722 16 also also RB cord-014516-r59usk02 2722 17 measured measure VBN cord-014516-r59usk02 2722 18 . . . cord-014516-r59usk02 2723 1 Glomerular glomerular JJ cord-014516-r59usk02 2723 2 filtration filtration NN cord-014516-r59usk02 2723 3 rate rate NN cord-014516-r59usk02 2723 4 significantly significantly RB cord-014516-r59usk02 2723 5 increased increase VBD cord-014516-r59usk02 2723 6 3 3 CD cord-014516-r59usk02 2723 7 months month NNS cord-014516-r59usk02 2723 8 after after IN cord-014516-r59usk02 2723 9 surgery surgery NN cord-014516-r59usk02 2723 10 ( ( -LRB- cord-014516-r59usk02 2723 11 40.0 40.0 CD cord-014516-r59usk02 2723 12 ml ml NN cord-014516-r59usk02 2723 13 / / SYM cord-014516-r59usk02 2723 14 min min NNP cord-014516-r59usk02 2723 15 / / SYM cord-014516-r59usk02 2723 16 m m NN cord-014516-r59usk02 2723 17 2 2 CD cord-014516-r59usk02 2723 18 [ [ -LRB- cord-014516-r59usk02 2723 19 25.6 25.6 CD cord-014516-r59usk02 2723 20 -123.0 -123.0 NN cord-014516-r59usk02 2723 21 ] ] -RRB- cord-014516-r59usk02 2723 22 , , , cord-014516-r59usk02 2723 23 2.7 2.7 CD cord-014516-r59usk02 2723 24 ml ml NN cord-014516-r59usk02 2723 25 / / SYM cord-014516-r59usk02 2723 26 min min NN cord-014516-r59usk02 2723 27 / / SYM cord-014516-r59usk02 2723 28 kg kg NNP cord-014516-r59usk02 2724 1 [ [ -LRB- cord-014516-r59usk02 2724 2 1.0 1.0 CD cord-014516-r59usk02 2724 3 -5.3 -5.3 NN cord-014516-r59usk02 2724 4 ] ] -RRB- cord-014516-r59usk02 2724 5 ) ) -RRB- cord-014516-r59usk02 2725 1 compared compare VBN cord-014516-r59usk02 2725 2 to to IN cord-014516-r59usk02 2725 3 before before IN cord-014516-r59usk02 2725 4 surgery surgery NN cord-014516-r59usk02 2725 5 ( ( -LRB- cord-014516-r59usk02 2725 6 38.4 38.4 CD cord-014516-r59usk02 2725 7 ml ml NN cord-014516-r59usk02 2725 8 / / SYM cord-014516-r59usk02 2725 9 min min NNP cord-014516-r59usk02 2725 10 / / SYM cord-014516-r59usk02 2725 11 m m NN cord-014516-r59usk02 2725 12 2 2 CD cord-014516-r59usk02 2725 13 [ [ -LRB- cord-014516-r59usk02 2725 14 12.6 12.6 CD cord-014516-r59usk02 2725 15 -50.3 -50.3 CD cord-014516-r59usk02 2725 16 ] ] -RRB- cord-014516-r59usk02 2725 17 , , , cord-014516-r59usk02 2725 18 2.2 2.2 CD cord-014516-r59usk02 2725 19 ml ml NN cord-014516-r59usk02 2725 20 / / SYM cord-014516-r59usk02 2725 21 min min NN cord-014516-r59usk02 2725 22 / / SYM cord-014516-r59usk02 2725 23 kg kg NN cord-014516-r59usk02 2725 24 [ [ -LRB- cord-014516-r59usk02 2725 25 0.7 0.7 CD cord-014516-r59usk02 2725 26 -3.8 -3.8 NNP cord-014516-r59usk02 2725 27 ] ] -RRB- cord-014516-r59usk02 2725 28 ) ) -RRB- cord-014516-r59usk02 2726 1 ( ( -LRB- cord-014516-r59usk02 2726 2 P p NN cord-014516-r59usk02 2726 3 < < XX cord-014516-r59usk02 2726 4 0.05 0.05 CD cord-014516-r59usk02 2726 5 ) ) -RRB- cord-014516-r59usk02 2726 6 . . . cord-014516-r59usk02 2727 1 The the DT cord-014516-r59usk02 2727 2 ISACHC isachc JJ cord-014516-r59usk02 2727 3 stage stage NN cord-014516-r59usk02 2727 4 of of IN cord-014516-r59usk02 2727 5 heart heart NN cord-014516-r59usk02 2727 6 failure failure NN cord-014516-r59usk02 2727 7 was be VBD cord-014516-r59usk02 2727 8 improved improve VBN cord-014516-r59usk02 2727 9 at at IN cord-014516-r59usk02 2727 10 3 3 CD cord-014516-r59usk02 2727 11 months month NNS cord-014516-r59usk02 2727 12 after after IN cord-014516-r59usk02 2727 13 surgery surgery NN cord-014516-r59usk02 2727 14 compared compare VBN cord-014516-r59usk02 2727 15 to to IN cord-014516-r59usk02 2727 16 before before IN cord-014516-r59usk02 2727 17 surgery surgery NN cord-014516-r59usk02 2727 18 . . . cord-014516-r59usk02 2728 1 In in IN cord-014516-r59usk02 2728 2 addition addition NN cord-014516-r59usk02 2728 3 , , , cord-014516-r59usk02 2728 4 serum serum NN cord-014516-r59usk02 2728 5 atrial atrial JJ cord-014516-r59usk02 2728 6 natriuretic natriuretic JJ cord-014516-r59usk02 2728 7 peptide peptide NN cord-014516-r59usk02 2728 8 level level NN cord-014516-r59usk02 2728 9 , , , cord-014516-r59usk02 2728 10 plasma plasma NN cord-014516-r59usk02 2728 11 NT NT NNP cord-014516-r59usk02 2728 12 - - HYPH cord-014516-r59usk02 2728 13 pro pro JJ cord-014516-r59usk02 2728 14 brain brain NN cord-014516-r59usk02 2728 15 natriuretic natriuretic JJ cord-014516-r59usk02 2728 16 peptide peptide JJ cord-014516-r59usk02 2728 17 level level NN cord-014516-r59usk02 2728 18 , , , cord-014516-r59usk02 2728 19 plasma plasma NN cord-014516-r59usk02 2728 20 urea urea NN cord-014516-r59usk02 2728 21 nitrogen nitrogen NN cord-014516-r59usk02 2728 22 concentration concentration NN cord-014516-r59usk02 2728 23 , , , cord-014516-r59usk02 2728 24 LA LA NNP cord-014516-r59usk02 2728 25 / / SYM cord-014516-r59usk02 2728 26 Ao Ao NNP cord-014516-r59usk02 2728 27 and and CC cord-014516-r59usk02 2728 28 VHS VHS NNP cord-014516-r59usk02 2728 29 significantly significantly RB cord-014516-r59usk02 2728 30 decreased decrease VBD cord-014516-r59usk02 2728 31 after after IN cord-014516-r59usk02 2728 32 surgery surgery NN cord-014516-r59usk02 2728 33 ( ( -LRB- cord-014516-r59usk02 2728 34 P p NN cord-014516-r59usk02 2728 35 < < XX cord-014516-r59usk02 2728 36 0.05 0.05 CD cord-014516-r59usk02 2728 37 ) ) -RRB- cord-014516-r59usk02 2728 38 . . . cord-014516-r59usk02 2729 1 The the DT cord-014516-r59usk02 2729 2 use use NN cord-014516-r59usk02 2729 3 of of IN cord-014516-r59usk02 2729 4 diuretics diuretic NNS cord-014516-r59usk02 2729 5 decreased decrease VBD cord-014516-r59usk02 2729 6 after after IN cord-014516-r59usk02 2729 7 mitral mitral JJ cord-014516-r59usk02 2729 8 valve valve NN cord-014516-r59usk02 2729 9 repair repair NN cord-014516-r59usk02 2729 10 surgery surgery NN cord-014516-r59usk02 2729 11 and and CC cord-014516-r59usk02 2729 12 consequently consequently RB cord-014516-r59usk02 2729 13 , , , cord-014516-r59usk02 2729 14 a a DT cord-014516-r59usk02 2729 15 decrease decrease NN cord-014516-r59usk02 2729 16 in in IN cord-014516-r59usk02 2729 17 plasma plasma NN cord-014516-r59usk02 2729 18 urea urea NN cord-014516-r59usk02 2729 19 nitrogen nitrogen NN cord-014516-r59usk02 2729 20 and and CC cord-014516-r59usk02 2729 21 creatinine creatinine NN cord-014516-r59usk02 2729 22 levels level NNS cord-014516-r59usk02 2729 23 were be VBD cord-014516-r59usk02 2729 24 observed observe VBN cord-014516-r59usk02 2729 25 . . . cord-014516-r59usk02 2730 1 Therefore therefore RB cord-014516-r59usk02 2730 2 , , , cord-014516-r59usk02 2730 3 this this DT cord-014516-r59usk02 2730 4 suggests suggest VBZ cord-014516-r59usk02 2730 5 that that IN cord-014516-r59usk02 2730 6 the the DT cord-014516-r59usk02 2730 7 main main JJ cord-014516-r59usk02 2730 8 cause cause NN cord-014516-r59usk02 2730 9 of of IN cord-014516-r59usk02 2730 10 azotemia azotemia NN cord-014516-r59usk02 2730 11 in in IN cord-014516-r59usk02 2730 12 dogs dog NNS cord-014516-r59usk02 2730 13 with with IN cord-014516-r59usk02 2730 14 mitral mitral JJ cord-014516-r59usk02 2730 15 regurgitation regurgitation NN cord-014516-r59usk02 2730 16 may may MD cord-014516-r59usk02 2730 17 be be VB cord-014516-r59usk02 2730 18 due due JJ cord-014516-r59usk02 2730 19 to to IN cord-014516-r59usk02 2730 20 inadequate inadequate JJ cord-014516-r59usk02 2730 21 renal renal JJ cord-014516-r59usk02 2730 22 blood blood NN cord-014516-r59usk02 2730 23 flow flow NN cord-014516-r59usk02 2730 24 and and CC cord-014516-r59usk02 2730 25 exacerbation exacerbation NN cord-014516-r59usk02 2730 26 by by IN cord-014516-r59usk02 2730 27 the the DT cord-014516-r59usk02 2730 28 use use NN cord-014516-r59usk02 2730 29 of of IN cord-014516-r59usk02 2730 30 diuretics diuretic NNS cord-014516-r59usk02 2730 31 . . . cord-014516-r59usk02 2731 1 No no DT cord-014516-r59usk02 2731 2 conflicts conflict NNS cord-014516-r59usk02 2731 3 of of IN cord-014516-r59usk02 2731 4 interest interest NN cord-014516-r59usk02 2731 5 reported report VBN cord-014516-r59usk02 2731 6 . . . cord-014516-r59usk02 2732 1 Glomerular glomerular JJ cord-014516-r59usk02 2732 2 filtration filtration NN cord-014516-r59usk02 2732 3 rate rate NN cord-014516-r59usk02 2732 4 ( ( -LRB- cord-014516-r59usk02 2732 5 GFR GFR NNP cord-014516-r59usk02 2732 6 ) ) -RRB- cord-014516-r59usk02 2732 7 is be VBZ cord-014516-r59usk02 2732 8 generally generally RB cord-014516-r59usk02 2732 9 considered consider VBN cord-014516-r59usk02 2732 10 to to TO cord-014516-r59usk02 2732 11 be be VB cord-014516-r59usk02 2732 12 the the DT cord-014516-r59usk02 2732 13 gold gold JJ cord-014516-r59usk02 2732 14 standard standard JJ cord-014516-r59usk02 2732 15 measurement measurement NN cord-014516-r59usk02 2732 16 of of IN cord-014516-r59usk02 2732 17 kidney kidney NN cord-014516-r59usk02 2732 18 function function NN cord-014516-r59usk02 2732 19 . . . cord-014516-r59usk02 2733 1 GFR GFR NNP cord-014516-r59usk02 2733 2 can can MD cord-014516-r59usk02 2733 3 be be VB cord-014516-r59usk02 2733 4 calculated calculate VBN cord-014516-r59usk02 2733 5 by by IN cord-014516-r59usk02 2733 6 measuring measure VBG cord-014516-r59usk02 2733 7 serum serum NN cord-014516-r59usk02 2733 8 iohexol iohexol NN cord-014516-r59usk02 2733 9 clearance clearance NN cord-014516-r59usk02 2733 10 using use VBG cord-014516-r59usk02 2733 11 concentrations concentration NNS cord-014516-r59usk02 2733 12 at at IN cord-014516-r59usk02 2733 13 2,3 2,3 CD cord-014516-r59usk02 2733 14 and and CC cord-014516-r59usk02 2733 15 4 4 CD cord-014516-r59usk02 2733 16 hours hour NNS cord-014516-r59usk02 2733 17 following follow VBG cord-014516-r59usk02 2733 18 a a DT cord-014516-r59usk02 2733 19 bolus bolus NN cord-014516-r59usk02 2733 20 injection injection NN cord-014516-r59usk02 2733 21 . . . cord-014516-r59usk02 2734 1 For for IN cord-014516-r59usk02 2734 2 validation validation NN cord-014516-r59usk02 2734 3 , , , cord-014516-r59usk02 2734 4 serum serum NN cord-014516-r59usk02 2734 5 samples sample NNS cord-014516-r59usk02 2734 6 were be VBD cord-014516-r59usk02 2734 7 spiked spike VBN cord-014516-r59usk02 2734 8 at at IN cord-014516-r59usk02 2734 9 low low JJ cord-014516-r59usk02 2734 10 ( ( -LRB- cord-014516-r59usk02 2734 11 0.017 0.017 CD cord-014516-r59usk02 2734 12 mg/ mg/ NN cord-014516-r59usk02 2734 13 mL mL NNP cord-014516-r59usk02 2734 14 ) ) -RRB- cord-014516-r59usk02 2734 15 , , , cord-014516-r59usk02 2734 16 medium medium NN cord-014516-r59usk02 2734 17 ( ( -LRB- cord-014516-r59usk02 2734 18 0.27 0.27 CD cord-014516-r59usk02 2734 19 mg mg NNP cord-014516-r59usk02 2734 20 / / SYM cord-014516-r59usk02 2734 21 mL mL NNP cord-014516-r59usk02 2734 22 ) ) -RRB- cord-014516-r59usk02 2734 23 and and CC cord-014516-r59usk02 2734 24 high high JJ cord-014516-r59usk02 2734 25 ( ( -LRB- cord-014516-r59usk02 2734 26 2.16 2.16 CD cord-014516-r59usk02 2734 27 mg mg NNP cord-014516-r59usk02 2734 28 / / SYM cord-014516-r59usk02 2734 29 mL mL NNP cord-014516-r59usk02 2734 30 ) ) -RRB- cord-014516-r59usk02 2734 31 iohexol iohexol NN cord-014516-r59usk02 2734 32 concentrations concentration NNS cord-014516-r59usk02 2734 33 . . . cord-014516-r59usk02 2735 1 They -PRON- PRP cord-014516-r59usk02 2735 2 were be VBD cord-014516-r59usk02 2735 3 analysed analyse VBN cord-014516-r59usk02 2735 4 , , , cord-014516-r59usk02 2735 5 along along IN cord-014516-r59usk02 2735 6 with with IN cord-014516-r59usk02 2735 7 standard standard JJ cord-014516-r59usk02 2735 8 calibration calibration NN cord-014516-r59usk02 2735 9 curves curve NNS cord-014516-r59usk02 2735 10 ( ( -LRB- cord-014516-r59usk02 2735 11 8 8 CD cord-014516-r59usk02 2735 12 concentrations concentration NNS cord-014516-r59usk02 2735 13 ranging range VBG cord-014516-r59usk02 2735 14 from from IN cord-014516-r59usk02 2735 15 0.017 0.017 CD cord-014516-r59usk02 2735 16 to to IN cord-014516-r59usk02 2735 17 2.16 2.16 CD cord-014516-r59usk02 2735 18 mg mg NNP cord-014516-r59usk02 2735 19 / / SYM cord-014516-r59usk02 2735 20 mL mL NNP cord-014516-r59usk02 2735 21 ) ) -RRB- cord-014516-r59usk02 2735 22 , , , cord-014516-r59usk02 2735 23 using use VBG cord-014516-r59usk02 2735 24 deltaDOT deltaDOT NNP cord-014516-r59usk02 2735 25 's 's POS cord-014516-r59usk02 2735 26 Label Label NNP cord-014516-r59usk02 2735 27 - - HYPH cord-014516-r59usk02 2735 28 Free free JJ cord-014516-r59usk02 2735 29 high high JJ cord-014516-r59usk02 2735 30 performance performance NN cord-014516-r59usk02 2735 31 capillary capillary NN cord-014516-r59usk02 2735 32 electrophoresis electrophoresis NN cord-014516-r59usk02 2735 33 ( ( -LRB- cord-014516-r59usk02 2735 34 HPCE HPCE NNP cord-014516-r59usk02 2735 35 ) ) -RRB- cord-014516-r59usk02 2735 36 system system NN cord-014516-r59usk02 2735 37 . . . cord-014516-r59usk02 2736 1 Data datum NNS cord-014516-r59usk02 2736 2 were be VBD cord-014516-r59usk02 2736 3 analysed analyse VBN cord-014516-r59usk02 2736 4 using use VBG cord-014516-r59usk02 2736 5 deltaDOT deltaDOT NNP cord-014516-r59usk02 2736 6 's 's POS cord-014516-r59usk02 2736 7 General General NNP cord-014516-r59usk02 2736 8 Separation Separation NNP cord-014516-r59usk02 2736 9 Transform transform VB cord-014516-r59usk02 2736 10 ( ( -LRB- cord-014516-r59usk02 2736 11 GST GST NNP cord-014516-r59usk02 2736 12 ) ) -RRB- cord-014516-r59usk02 2736 13 . . . cord-014516-r59usk02 2737 1 Clinical clinical JJ cord-014516-r59usk02 2737 2 and and CC cord-014516-r59usk02 2737 3 spiked spiked JJ cord-014516-r59usk02 2737 4 serum serum NN cord-014516-r59usk02 2737 5 samples sample NNS cord-014516-r59usk02 2737 6 were be VBD cord-014516-r59usk02 2737 7 also also RB cord-014516-r59usk02 2737 8 sent send VBN cord-014516-r59usk02 2737 9 for for IN cord-014516-r59usk02 2737 10 analysis analysis NN cord-014516-r59usk02 2737 11 by by IN cord-014516-r59usk02 2737 12 mass mass NN cord-014516-r59usk02 2737 13 spectrometry spectrometry NNP cord-014516-r59usk02 2737 14 ( ( -LRB- cord-014516-r59usk02 2737 15 MS MS NNP cord-014516-r59usk02 2737 16 ) ) -RRB- cord-014516-r59usk02 2737 17 at at IN cord-014516-r59usk02 2737 18 a a DT cord-014516-r59usk02 2737 19 reference reference NN cord-014516-r59usk02 2737 20 laboratory laboratory NN cord-014516-r59usk02 2737 21 ( ( -LRB- cord-014516-r59usk02 2737 22 14 14 CD cord-014516-r59usk02 2737 23 samples sample NNS cord-014516-r59usk02 2737 24 for for IN cord-014516-r59usk02 2737 25 comparison comparison NN cord-014516-r59usk02 2737 26 ) ) -RRB- cord-014516-r59usk02 2737 27 . . . cord-014516-r59usk02 2738 1 Concentrations concentration NNS cord-014516-r59usk02 2738 2 obtained obtain VBN cord-014516-r59usk02 2738 3 by by IN cord-014516-r59usk02 2738 4 HPCE HPCE NNP cord-014516-r59usk02 2738 5 and and CC cord-014516-r59usk02 2738 6 MS MS NNP cord-014516-r59usk02 2738 7 were be VBD cord-014516-r59usk02 2738 8 compared compare VBN cord-014516-r59usk02 2738 9 in in IN cord-014516-r59usk02 2738 10 a a DT cord-014516-r59usk02 2738 11 Bland Bland NNP cord-014516-r59usk02 2738 12 Altman Altman NNP cord-014516-r59usk02 2738 13 plot plot NN cord-014516-r59usk02 2738 14 . . . cord-014516-r59usk02 2739 1 GFR GFR NNP cord-014516-r59usk02 2739 2 for for IN cord-014516-r59usk02 2739 3 clinical clinical JJ cord-014516-r59usk02 2739 4 samples sample NNS cord-014516-r59usk02 2739 5 was be VBD cord-014516-r59usk02 2739 6 calculated calculate VBN cord-014516-r59usk02 2739 7 from from IN cord-014516-r59usk02 2739 8 the the DT cord-014516-r59usk02 2739 9 measured measure VBN cord-014516-r59usk02 2739 10 iohexol iohexol NN cord-014516-r59usk02 2739 11 concentrations concentration NNS cord-014516-r59usk02 2739 12 using use VBG cord-014516-r59usk02 2739 13 the the DT cord-014516-r59usk02 2739 14 method method NN cord-014516-r59usk02 2739 15 reported report VBN cord-014516-r59usk02 2739 16 by by IN cord-014516-r59usk02 2739 17 Bexfield Bexfield NNP cord-014516-r59usk02 2739 18 ( ( -LRB- cord-014516-r59usk02 2739 19 2008 2008 CD cord-014516-r59usk02 2739 20 ) ) -RRB- cord-014516-r59usk02 2739 21 . . . cord-014516-r59usk02 2740 1 A a DT cord-014516-r59usk02 2740 2 validated validated JJ cord-014516-r59usk02 2740 3 method method NN cord-014516-r59usk02 2740 4 was be VBD cord-014516-r59usk02 2740 5 produced produce VBN cord-014516-r59usk02 2740 6 , , , cord-014516-r59usk02 2740 7 with with IN cord-014516-r59usk02 2740 8 a a DT cord-014516-r59usk02 2740 9 lower low JJR cord-014516-r59usk02 2740 10 limit limit NN cord-014516-r59usk02 2740 11 of of IN cord-014516-r59usk02 2740 12 detection detection NN cord-014516-r59usk02 2740 13 of of IN cord-014516-r59usk02 2740 14 0.009 0.009 CD cord-014516-r59usk02 2740 15 mg mg NNP cord-014516-r59usk02 2740 16 / / SYM cord-014516-r59usk02 2740 17 mL ml NN cord-014516-r59usk02 2740 18 and and CC cord-014516-r59usk02 2740 19 an an DT cord-014516-r59usk02 2740 20 lower low JJR cord-014516-r59usk02 2740 21 limit limit NN cord-014516-r59usk02 2740 22 of of IN cord-014516-r59usk02 2740 23 quantification quantification NN cord-014516-r59usk02 2740 24 of of IN cord-014516-r59usk02 2740 25 0.017 0.017 CD cord-014516-r59usk02 2740 26 mg mg NNP cord-014516-r59usk02 2740 27 / / SYM cord-014516-r59usk02 2740 28 mL. ml. NN cord-014516-r59usk02 2740 29 The the DT cord-014516-r59usk02 2740 30 upper upper JJ cord-014516-r59usk02 2740 31 limit limit NN cord-014516-r59usk02 2740 32 of of IN cord-014516-r59usk02 2740 33 quantification quantification NN cord-014516-r59usk02 2740 34 was be VBD cord-014516-r59usk02 2740 35 2.16 2.16 CD cord-014516-r59usk02 2740 36 mg/ mg/ NN cord-014516-r59usk02 2741 1 mL. mL. NNP cord-014516-r59usk02 2742 1 The the DT cord-014516-r59usk02 2742 2 standard standard JJ cord-014516-r59usk02 2742 3 curve curve NN cord-014516-r59usk02 2742 4 had have VBD cord-014516-r59usk02 2742 5 excellent excellent JJ cord-014516-r59usk02 2742 6 linearity linearity NN cord-014516-r59usk02 2743 1 ( ( -LRB- cord-014516-r59usk02 2743 2 R r NN cord-014516-r59usk02 2743 3 2 2 CD cord-014516-r59usk02 2743 4 = = SYM cord-014516-r59usk02 2743 5 0.993 0.993 CD cord-014516-r59usk02 2743 6 ) ) -RRB- cord-014516-r59usk02 2743 7 . . . cord-014516-r59usk02 2744 1 Maximum maximum JJ cord-014516-r59usk02 2744 2 inaccuracy inaccuracy NN cord-014516-r59usk02 2744 3 was be VBD cord-014516-r59usk02 2744 4 less less JJR cord-014516-r59usk02 2744 5 than than IN cord-014516-r59usk02 2744 6 11.5 11.5 CD cord-014516-r59usk02 2744 7 % % NN cord-014516-r59usk02 2744 8 of of IN cord-014516-r59usk02 2744 9 the the DT cord-014516-r59usk02 2744 10 true true JJ cord-014516-r59usk02 2744 11 value value NN cord-014516-r59usk02 2744 12 , , , cord-014516-r59usk02 2744 13 except except IN cord-014516-r59usk02 2744 14 at at IN cord-014516-r59usk02 2744 15 LLOQ LLOQ NNP cord-014516-r59usk02 2744 16 , , , cord-014516-r59usk02 2744 17 where where WRB cord-014516-r59usk02 2744 18 it -PRON- PRP cord-014516-r59usk02 2744 19 was be VBD cord-014516-r59usk02 2744 20 within within IN cord-014516-r59usk02 2744 21 24.2 24.2 CD cord-014516-r59usk02 2744 22 % % NN cord-014516-r59usk02 2744 23 . . . cord-014516-r59usk02 2745 1 Average average JJ cord-014516-r59usk02 2745 2 within within IN cord-014516-r59usk02 2745 3 day day NN cord-014516-r59usk02 2745 4 variability variability NN cord-014516-r59usk02 2745 5 was be VBD cord-014516-r59usk02 2745 6 less less JJR cord-014516-r59usk02 2745 7 than than IN cord-014516-r59usk02 2745 8 13.1 13.1 CD cord-014516-r59usk02 2745 9 % % NN cord-014516-r59usk02 2745 10 at at IN cord-014516-r59usk02 2745 11 all all DT cord-014516-r59usk02 2745 12 levels level NNS cord-014516-r59usk02 2745 13 , , , cord-014516-r59usk02 2745 14 while while IN cord-014516-r59usk02 2745 15 between between IN cord-014516-r59usk02 2745 16 day day NN cord-014516-r59usk02 2745 17 variability variability NN cord-014516-r59usk02 2745 18 was be VBD cord-014516-r59usk02 2745 19 less less JJR cord-014516-r59usk02 2745 20 than than IN cord-014516-r59usk02 2745 21 5.6 5.6 CD cord-014516-r59usk02 2745 22 % % NN cord-014516-r59usk02 2745 23 , , , cord-014516-r59usk02 2745 24 except except IN cord-014516-r59usk02 2745 25 at at IN cord-014516-r59usk02 2745 26 LLOQ LLOQ NNP cord-014516-r59usk02 2745 27 , , , cord-014516-r59usk02 2745 28 where where WRB cord-014516-r59usk02 2745 29 it -PRON- PRP cord-014516-r59usk02 2745 30 was be VBD cord-014516-r59usk02 2745 31 less less JJR cord-014516-r59usk02 2745 32 than than IN cord-014516-r59usk02 2745 33 15.4 15.4 CD cord-014516-r59usk02 2745 34 % % NN cord-014516-r59usk02 2745 35 . . . cord-014516-r59usk02 2746 1 Agreement agreement NN cord-014516-r59usk02 2746 2 between between IN cord-014516-r59usk02 2746 3 the the DT cord-014516-r59usk02 2746 4 results result NNS cord-014516-r59usk02 2746 5 obtained obtain VBN cord-014516-r59usk02 2746 6 by by IN cord-014516-r59usk02 2746 7 measurement measurement NN cord-014516-r59usk02 2746 8 with with IN cord-014516-r59usk02 2746 9 HPCE HPCE NNP cord-014516-r59usk02 2746 10 and and CC cord-014516-r59usk02 2746 11 MS MS NNP cord-014516-r59usk02 2746 12 was be VBD cord-014516-r59usk02 2746 13 good good JJ cord-014516-r59usk02 2746 14 ( ( -LRB- cord-014516-r59usk02 2746 15 bias bias NN cord-014516-r59usk02 2746 16 1.3 1.3 CD cord-014516-r59usk02 2746 17 % % NN cord-014516-r59usk02 2746 18 , , , cord-014516-r59usk02 2746 19 lower low JJR cord-014516-r59usk02 2746 20 and and CC cord-014516-r59usk02 2746 21 upper upper JJ cord-014516-r59usk02 2746 22 limits limit NNS cord-014516-r59usk02 2746 23 of of IN cord-014516-r59usk02 2746 24 agreement agreement NN cord-014516-r59usk02 2746 25 of of IN cord-014516-r59usk02 2746 26 -15.4 -15.4 : cord-014516-r59usk02 2746 27 and and CC cord-014516-r59usk02 2746 28 18.0 18.0 CD cord-014516-r59usk02 2746 29 % % NN cord-014516-r59usk02 2746 30 , , , cord-014516-r59usk02 2746 31 respectively respectively RB cord-014516-r59usk02 2746 32 ) ) -RRB- cord-014516-r59usk02 2746 33 . . . cord-014516-r59usk02 2747 1 Method method NN cord-014516-r59usk02 2747 2 specificity specificity NN cord-014516-r59usk02 2747 3 was be VBD cord-014516-r59usk02 2747 4 confirmed confirm VBN cord-014516-r59usk02 2747 5 by by IN cord-014516-r59usk02 2747 6 the the DT cord-014516-r59usk02 2747 7 absence absence NN cord-014516-r59usk02 2747 8 of of IN cord-014516-r59usk02 2747 9 matrix matrix NN cord-014516-r59usk02 2747 10 effect effect NN cord-014516-r59usk02 2747 11 in in IN cord-014516-r59usk02 2747 12 six six CD cord-014516-r59usk02 2747 13 serum serum NN cord-014516-r59usk02 2747 14 specimen specimen NN cord-014516-r59usk02 2747 15 obtained obtain VBN cord-014516-r59usk02 2747 16 from from IN cord-014516-r59usk02 2747 17 clinical clinical JJ cord-014516-r59usk02 2747 18 dogs dog NNS cord-014516-r59usk02 2747 19 . . . cord-014516-r59usk02 2748 1 Clinical clinical JJ cord-014516-r59usk02 2748 2 samples sample NNS cord-014516-r59usk02 2748 3 were be VBD cord-014516-r59usk02 2748 4 analysed analyse VBN cord-014516-r59usk02 2748 5 and and CC cord-014516-r59usk02 2748 6 GFR GFR NNP cord-014516-r59usk02 2748 7 reported report VBD cord-014516-r59usk02 2748 8 with with IN cord-014516-r59usk02 2748 9 a a DT cord-014516-r59usk02 2748 10 3 3 CD cord-014516-r59usk02 2748 11 day day NN cord-014516-r59usk02 2748 12 turnaround turnaround NN cord-014516-r59usk02 2748 13 time time NN cord-014516-r59usk02 2748 14 . . . cord-014516-r59usk02 2749 1 In in IN cord-014516-r59usk02 2749 2 conclusion conclusion NN cord-014516-r59usk02 2749 3 , , , cord-014516-r59usk02 2749 4 HPCE HPCE NNP cord-014516-r59usk02 2749 5 provides provide VBZ cord-014516-r59usk02 2749 6 an an DT cord-014516-r59usk02 2749 7 accurate accurate JJ cord-014516-r59usk02 2749 8 and and CC cord-014516-r59usk02 2749 9 precise precise JJ cord-014516-r59usk02 2749 10 method method NN cord-014516-r59usk02 2749 11 for for IN cord-014516-r59usk02 2749 12 measuring measure VBG cord-014516-r59usk02 2749 13 iohexol iohexol NN cord-014516-r59usk02 2749 14 in in IN cord-014516-r59usk02 2749 15 canine canine JJ cord-014516-r59usk02 2749 16 serum serum NN cord-014516-r59usk02 2749 17 . . . cord-014516-r59usk02 2750 1 Conflicts conflict NNS cord-014516-r59usk02 2750 2 of of IN cord-014516-r59usk02 2750 3 interest interest NN cord-014516-r59usk02 2751 1 : : : cord-014516-r59usk02 2751 2 L L NNP cord-014516-r59usk02 2751 3 Pelligand Pelligand NNP cord-014516-r59usk02 2751 4 has have VBZ cord-014516-r59usk02 2751 5 the the DT cord-014516-r59usk02 2751 6 following follow VBG cord-014516-r59usk02 2751 7 information information NN cord-014516-r59usk02 2751 8 to to TO cord-014516-r59usk02 2751 9 disclose disclose VB cord-014516-r59usk02 2751 10 : : : cord-014516-r59usk02 2751 11 In in IN cord-014516-r59usk02 2751 12 receipt receipt NN cord-014516-r59usk02 2751 13 of of IN cord-014516-r59usk02 2751 14 research research NN cord-014516-r59usk02 2751 15 grant grant NN cord-014516-r59usk02 2751 16 / / SYM cord-014516-r59usk02 2751 17 contract contract NN cord-014516-r59usk02 2751 18 funding funding NN cord-014516-r59usk02 2751 19 from from IN cord-014516-r59usk02 2751 20 Orion Orion NNP cord-014516-r59usk02 2751 21 Ltd. Ltd. NNP cord-014516-r59usk02 2751 22 , , , cord-014516-r59usk02 2751 23 Novartis Novartis NNP cord-014516-r59usk02 2751 24 Animal Animal NNP cord-014516-r59usk02 2751 25 Health Health NNP cord-014516-r59usk02 2751 26 , , , cord-014516-r59usk02 2751 27 Transpharmation Transpharmation NNP cord-014516-r59usk02 2751 28 Ltd Ltd NNP cord-014516-r59usk02 2751 29 , , , cord-014516-r59usk02 2751 30 DeltaDot DeltaDot NNP cord-014516-r59usk02 2751 31 Ltd Ltd NNP cord-014516-r59usk02 2751 32 ; ; : cord-014516-r59usk02 2751 33 Acted act VBD cord-014516-r59usk02 2751 34 as as IN cord-014516-r59usk02 2751 35 a a DT cord-014516-r59usk02 2751 36 consultant consultant NN cord-014516-r59usk02 2751 37 for for IN cord-014516-r59usk02 2751 38 : : : cord-014516-r59usk02 2751 39 Triveritas Triveritas NNP cord-014516-r59usk02 2751 40 Ltd. Ltd. NNP cord-014516-r59usk02 2751 41 and and CC cord-014516-r59usk02 2751 42 Novartis Novartis NNP cord-014516-r59usk02 2751 43 Animal Animal NNP cord-014516-r59usk02 2751 44 Health Health NNP cord-014516-r59usk02 2751 45 ; ; : cord-014516-r59usk02 2751 46 S S NNP cord-014516-r59usk02 2751 47 Williams Williams NNP cord-014516-r59usk02 2751 48 is be VBZ cord-014516-r59usk02 2751 49 an an DT cord-014516-r59usk02 2751 50 employee employee NN cord-014516-r59usk02 2751 51 of of IN cord-014516-r59usk02 2751 52 the the DT cord-014516-r59usk02 2751 53 RVC RVC NNP cord-014516-r59usk02 2751 54 and and CC cord-014516-r59usk02 2751 55 works work VBZ cord-014516-r59usk02 2751 56 in in IN cord-014516-r59usk02 2751 57 collaboration collaboration NN cord-014516-r59usk02 2751 58 with with IN cord-014516-r59usk02 2751 59 deltaDot deltaDot NNP cord-014516-r59usk02 2751 60 Ltd Ltd NNP cord-014516-r59usk02 2751 61 ; ; : cord-014516-r59usk02 2751 62 J. J. NNP cord-014516-r59usk02 2751 63 Elliott Elliott NNP cord-014516-r59usk02 2751 64 has have VBZ cord-014516-r59usk02 2751 65 the the DT cord-014516-r59usk02 2751 66 following follow VBG cord-014516-r59usk02 2751 67 information information NN cord-014516-r59usk02 2751 68 to to TO cord-014516-r59usk02 2751 69 disclose disclose VB cord-014516-r59usk02 2751 70 : : : cord-014516-r59usk02 2751 71 Consultancy consultancy NN cord-014516-r59usk02 2751 72 : : : cord-014516-r59usk02 2751 73 Pfizer Pfizer NNP cord-014516-r59usk02 2751 74 Animal Animal NNP cord-014516-r59usk02 2751 75 Health Health NNP cord-014516-r59usk02 2751 76 / / SYM cord-014516-r59usk02 2751 77 Zoetis Zoetis NNP cord-014516-r59usk02 2751 78 , , , cord-014516-r59usk02 2751 79 CEVA CEVA NNP cord-014516-r59usk02 2751 80 Animal Animal NNP cord-014516-r59usk02 2751 81 Health Health NNP cord-014516-r59usk02 2751 82 , , , cord-014516-r59usk02 2751 83 Boehringer Boehringer NNP cord-014516-r59usk02 2751 84 Ingelheim Ingelheim NNP cord-014516-r59usk02 2751 85 , , , cord-014516-r59usk02 2751 86 Vetoquinol Vetoquinol NNP cord-014516-r59usk02 2751 87 Ltd Ltd NNP cord-014516-r59usk02 2751 88 , , , cord-014516-r59usk02 2751 89 Orion Orion NNP cord-014516-r59usk02 2751 90 Ltd. Ltd. NNP cord-014516-r59usk02 2751 91 , , , cord-014516-r59usk02 2751 92 Elanco Elanco NNP cord-014516-r59usk02 2751 93 Ltd Ltd NNP cord-014516-r59usk02 2751 94 , , , cord-014516-r59usk02 2751 95 Idexx Idexx NNP cord-014516-r59usk02 2751 96 Ltd Ltd NNP cord-014516-r59usk02 2751 97 , , , cord-014516-r59usk02 2752 1 Niche Niche NNP cord-014516-r59usk02 2752 2 Generics Generics NNPS cord-014516-r59usk02 2752 3 Ltd. Ltd. NNP cord-014516-r59usk02 2752 4 Triveristas Triveristas NNP cord-014516-r59usk02 2752 5 Ltd. Ltd. NNP cord-014516-r59usk02 2752 6 , , , cord-014516-r59usk02 2752 7 Virbac Virbac NNP cord-014516-r59usk02 2752 8 Ltd. Ltd. NNP cord-014516-r59usk02 2752 9 , , , cord-014516-r59usk02 2752 10 Advisory Advisory NNP cord-014516-r59usk02 2752 11 board board NN cord-014516-r59usk02 2752 12 membership membership NN cord-014516-r59usk02 2752 13 : : : cord-014516-r59usk02 2753 1 International International NNP cord-014516-r59usk02 2753 2 Renal Renal NNP cord-014516-r59usk02 2753 3 Interest Interest NNP cord-014516-r59usk02 2753 4 Society Society NNP cord-014516-r59usk02 2753 5 ( ( -LRB- cord-014516-r59usk02 2753 6 supported support VBN cord-014516-r59usk02 2753 7 by by IN cord-014516-r59usk02 2753 8 Novartis Novartis NNP cord-014516-r59usk02 2753 9 ) ) -RRB- cord-014516-r59usk02 2754 1 European European NNP cord-014516-r59usk02 2754 2 Emesis Emesis NNP cord-014516-r59usk02 2754 3 Council Council NNP cord-014516-r59usk02 2754 4 ( ( -LRB- cord-014516-r59usk02 2754 5 sponsored sponsor VBN cord-014516-r59usk02 2754 6 by by IN cord-014516-r59usk02 2754 7 Pfizer Pfizer NNP cord-014516-r59usk02 2754 8 Animal Animal NNP cord-014516-r59usk02 2754 9 Health Health NNP cord-014516-r59usk02 2754 10 -now -now : cord-014516-r59usk02 2755 1 Zoetis Zoetis NNP cord-014516-r59usk02 2755 2 ) ) -RRB- cord-014516-r59usk02 2756 1 Cardiorenal Cardiorenal NNP cord-014516-r59usk02 2756 2 Board Board NNP cord-014516-r59usk02 2757 1 -Vetoquinol -Vetoquinol . cord-014516-r59usk02 2758 1 Ltd. Ltd. NNP cord-014516-r59usk02 2759 1 Idexx Idexx NNP cord-014516-r59usk02 2759 2 Renal Renal NNP cord-014516-r59usk02 2759 3 Advisory Advisory NNP cord-014516-r59usk02 2759 4 Board Board NNP cord-014516-r59usk02 2759 5 Research Research NNP cord-014516-r59usk02 2759 6 Grants Grants NNPS cord-014516-r59usk02 2759 7 or or CC cord-014516-r59usk02 2759 8 contracts contract NNS cord-014516-r59usk02 2759 9 : : : cord-014516-r59usk02 2759 10 Vetoquinol Vetoquinol NNP cord-014516-r59usk02 2759 11 Ltd Ltd NNP cord-014516-r59usk02 2759 12 , , , cord-014516-r59usk02 2759 13 Novartis Novartis NNP cord-014516-r59usk02 2759 14 Ltd Ltd NNP cord-014516-r59usk02 2759 15 , , , cord-014516-r59usk02 2759 16 Pfizer Pfizer NNP cord-014516-r59usk02 2759 17 Animal Animal NNP cord-014516-r59usk02 2759 18 Health Health NNP cord-014516-r59usk02 2759 19 Ltd Ltd NNP cord-014516-r59usk02 2759 20 ( ( -LRB- cord-014516-r59usk02 2759 21 now now RB cord-014516-r59usk02 2759 22 Zoetis Zoetis NNP cord-014516-r59usk02 2759 23 ) ) -RRB- cord-014516-r59usk02 2759 24 , , , cord-014516-r59usk02 2759 25 Royal Royal NNP cord-014516-r59usk02 2759 26 Canin Canin NNP cord-014516-r59usk02 2759 27 Ltd Ltd NNP cord-014516-r59usk02 2759 28 , , , cord-014516-r59usk02 2759 29 Boeringher Boeringher NNP cord-014516-r59usk02 2759 30 Ingelheim Ingelheim NNP cord-014516-r59usk02 2759 31 Ltd Ltd NNP cord-014516-r59usk02 2759 32 , , , cord-014516-r59usk02 2759 33 Waltham Waltham NNP cord-014516-r59usk02 2759 34 Centre Centre NNP cord-014516-r59usk02 2759 35 for for IN cord-014516-r59usk02 2759 36 Pet Pet NNP cord-014516-r59usk02 2759 37 Nutrition Nutrition NNP cord-014516-r59usk02 2759 38 , , , cord-014516-r59usk02 2760 1 CEVA CEVA NNP cord-014516-r59usk02 2760 2 Animal Animal NNP cord-014516-r59usk02 2760 3 Health Health NNP cord-014516-r59usk02 2760 4 Orion Orion NNP cord-014516-r59usk02 2760 5 Ltd. Ltd. NNP cord-014516-r59usk02 2760 6 ESVONC ESVONC NNP cord-014516-r59usk02 2760 7 - - HYPH cord-014516-r59usk02 2760 8 P-1 P-1 NNP cord-014516-r59usk02 2760 9 CYSTIC cystic JJ cord-014516-r59usk02 2760 10 PANCREATIC pancreatic NN cord-014516-r59usk02 2760 11 NEOPLASIA neoplasia NN cord-014516-r59usk02 2760 12 IN in IN cord-014516-r59usk02 2760 13 CATS cat NNS cord-014516-r59usk02 2760 14 . . . cord-014516-r59usk02 2761 1 C.M. C.M. NNP cord-014516-r59usk02 2761 2 Borschensky Borschensky NNP cord-014516-r59usk02 2761 3 1 1 NNP cord-014516-r59usk02 2761 4 , , , cord-014516-r59usk02 2761 5 K. K. NNP cord-014516-r59usk02 2761 6 Steiger Steiger NNP cord-014516-r59usk02 2761 7 2 2 CD cord-014516-r59usk02 2761 8 , , , cord-014516-r59usk02 2761 9 A. A. NNP cord-014516-r59usk02 2761 10 Staudacher Staudacher NNP cord-014516-r59usk02 2761 11 3 3 CD cord-014516-r59usk02 2761 12 , , , cord-014516-r59usk02 2761 13 M. M. NNP cord-014516-r59usk02 2761 14 Schlitter Schlitter NNP cord-014516-r59usk02 2761 15 2 2 CD cord-014516-r59usk02 2761 16 , , , cord-014516-r59usk02 2761 17 I. I. NNP cord-014516-r59usk02 2761 18 Esposito Esposito NNP cord-014516-r59usk02 2761 19 2 2 CD cord-014516-r59usk02 2761 20 , , , cord-014516-r59usk02 2761 21 H. H. NNP cord-014516-r59usk02 2761 22 Aupperle Aupperle NNP cord-014516-r59usk02 2761 23 1 1 CD cord-014516-r59usk02 2761 24 . . . cord-014516-r59usk02 2762 1 1 1 LS cord-014516-r59usk02 2763 1 Laboklin Laboklin NNP cord-014516-r59usk02 2763 2 GmbH&Co GmbH&Co NNPS cord-014516-r59usk02 2763 3 . . . cord-014516-r59usk02 2764 1 KG kg NN cord-014516-r59usk02 2764 2 , , , cord-014516-r59usk02 2764 3 Bad bad JJ cord-014516-r59usk02 2764 4 kissingen kissingen NN cord-014516-r59usk02 2764 5 , , , cord-014516-r59usk02 2764 6 Germany Germany NNP cord-014516-r59usk02 2764 7 , , , cord-014516-r59usk02 2764 8 2 2 CD cord-014516-r59usk02 2764 9 TU TU NNP cord-014516-r59usk02 2764 10 M€ M€ NNP cord-014516-r59usk02 2764 11 unchen unchen NNP cord-014516-r59usk02 2764 12 , , , cord-014516-r59usk02 2764 13 Institute Institute NNP cord-014516-r59usk02 2764 14 of of IN cord-014516-r59usk02 2764 15 Pathology Pathology NNP cord-014516-r59usk02 2764 16 , , , cord-014516-r59usk02 2764 17 M€ M€ NNP cord-014516-r59usk02 2764 18 unchen unchen NNP cord-014516-r59usk02 2764 19 , , , cord-014516-r59usk02 2764 20 Germany Germany NNP cord-014516-r59usk02 2764 21 , , , cord-014516-r59usk02 2764 22 3 3 CD cord-014516-r59usk02 2764 23 Veterinary Veterinary NNP cord-014516-r59usk02 2764 24 Clinic Clinic NNP cord-014516-r59usk02 2764 25 Dr. Dr. NNP cord-014516-r59usk02 2764 26 Staudacher Staudacher NNP cord-014516-r59usk02 2764 27 , , , cord-014516-r59usk02 2764 28 Aachen Aachen NNP cord-014516-r59usk02 2764 29 , , , cord-014516-r59usk02 2764 30 Germany Germany NNP cord-014516-r59usk02 2764 31 Pancreatic pancreatic JJ cord-014516-r59usk02 2764 32 neoplasms neoplasm NNS cord-014516-r59usk02 2764 33 in in IN cord-014516-r59usk02 2764 34 the the DT cord-014516-r59usk02 2764 35 cat cat NN cord-014516-r59usk02 2764 36 mostly mostly RB cord-014516-r59usk02 2764 37 exhibit exhibit VBP cord-014516-r59usk02 2764 38 a a DT cord-014516-r59usk02 2764 39 solid solid JJ cord-014516-r59usk02 2764 40 growth growth NN cord-014516-r59usk02 2764 41 pattern pattern NN cord-014516-r59usk02 2764 42 and and CC cord-014516-r59usk02 2764 43 are be VBP cord-014516-r59usk02 2764 44 diagnosed diagnose VBN cord-014516-r59usk02 2764 45 as as IN cord-014516-r59usk02 2764 46 carcinomas carcinoma NNS cord-014516-r59usk02 2764 47 . . . cord-014516-r59usk02 2765 1 In in IN cord-014516-r59usk02 2765 2 contrast contrast NN cord-014516-r59usk02 2765 3 , , , cord-014516-r59usk02 2765 4 only only RB cord-014516-r59usk02 2765 5 few few JJ cord-014516-r59usk02 2765 6 reports report NNS cord-014516-r59usk02 2765 7 about about IN cord-014516-r59usk02 2765 8 cystic cystic JJ cord-014516-r59usk02 2765 9 pancreatic pancreatic JJ cord-014516-r59usk02 2765 10 lesions lesion NNS cord-014516-r59usk02 2765 11 exist exist VBP cord-014516-r59usk02 2765 12 . . . cord-014516-r59usk02 2766 1 Until until IN cord-014516-r59usk02 2766 2 now now RB cord-014516-r59usk02 2766 3 , , , cord-014516-r59usk02 2766 4 only only RB cord-014516-r59usk02 2766 5 benign benign JJ cord-014516-r59usk02 2766 6 cystic cystic JJ cord-014516-r59usk02 2766 7 pancreatic pancreatic JJ cord-014516-r59usk02 2766 8 lesions lesion NNS cord-014516-r59usk02 2766 9 are be VBP cord-014516-r59usk02 2766 10 described describe VBN cord-014516-r59usk02 2766 11 in in IN cord-014516-r59usk02 2766 12 the the DT cord-014516-r59usk02 2766 13 literature literature NN cord-014516-r59usk02 2766 14 . . . cord-014516-r59usk02 2767 1 According accord VBG cord-014516-r59usk02 2767 2 to to IN cord-014516-r59usk02 2767 3 the the DT cord-014516-r59usk02 2767 4 histological histological JJ cord-014516-r59usk02 2767 5 pattern pattern NN cord-014516-r59usk02 2767 6 , , , cord-014516-r59usk02 2767 7 they -PRON- PRP cord-014516-r59usk02 2767 8 have have VBP cord-014516-r59usk02 2767 9 been be VBN cord-014516-r59usk02 2767 10 termed term VBN cord-014516-r59usk02 2767 11 as as IN cord-014516-r59usk02 2767 12 cysts cyst NNS cord-014516-r59usk02 2767 13 , , , cord-014516-r59usk02 2767 14 ( ( -LRB- cord-014516-r59usk02 2767 15 acinar acinar NNP cord-014516-r59usk02 2767 16 ) ) -RRB- cord-014516-r59usk02 2767 17 cystadenoma cystadenoma NNP cord-014516-r59usk02 2767 18 or or CC cord-014516-r59usk02 2767 19 pseudocysts pseudocyst NNS cord-014516-r59usk02 2767 20 . . . cord-014516-r59usk02 2768 1 In in IN cord-014516-r59usk02 2768 2 man man NN cord-014516-r59usk02 2768 3 , , , cord-014516-r59usk02 2768 4 cystic cystic JJ cord-014516-r59usk02 2768 5 pancreatic pancreatic JJ cord-014516-r59usk02 2768 6 neoplasms neoplasm NNS cord-014516-r59usk02 2768 7 are be VBP cord-014516-r59usk02 2768 8 classified classify VBN cord-014516-r59usk02 2768 9 according accord VBG cord-014516-r59usk02 2768 10 to to IN cord-014516-r59usk02 2768 11 the the DT cord-014516-r59usk02 2768 12 localisation localisation NN cord-014516-r59usk02 2768 13 ( ( -LRB- cord-014516-r59usk02 2768 14 intra-/extraductal intra-/extraductal NNP cord-014516-r59usk02 2768 15 ) ) -RRB- cord-014516-r59usk02 2768 16 , , , cord-014516-r59usk02 2768 17 growth growth NN cord-014516-r59usk02 2768 18 pattern pattern NN cord-014516-r59usk02 2768 19 and and CC cord-014516-r59usk02 2768 20 differentiation differentiation NN cord-014516-r59usk02 2768 21 ( ( -LRB- cord-014516-r59usk02 2768 22 mucinous mucinous JJ cord-014516-r59usk02 2768 23 , , , cord-014516-r59usk02 2768 24 ( ( -LRB- cord-014516-r59usk02 2768 25 tubulo)papillary tubulo)papillary NNP cord-014516-r59usk02 2768 26 , , , cord-014516-r59usk02 2768 27 serous serous JJ cord-014516-r59usk02 2768 28 , , , cord-014516-r59usk02 2768 29 acinar acinar NNP cord-014516-r59usk02 2768 30 ) ) -RRB- cord-014516-r59usk02 2768 31 . . . cord-014516-r59usk02 2769 1 The the DT cord-014516-r59usk02 2769 2 aim aim NN cord-014516-r59usk02 2769 3 of of IN cord-014516-r59usk02 2769 4 this this DT cord-014516-r59usk02 2769 5 study study NN cord-014516-r59usk02 2769 6 was be VBD cord-014516-r59usk02 2769 7 to to TO cord-014516-r59usk02 2769 8 characterise characterise VB cord-014516-r59usk02 2769 9 feline feline JJ cord-014516-r59usk02 2769 10 pancreatic pancreatic JJ cord-014516-r59usk02 2769 11 neoplasms neoplasm NNS cord-014516-r59usk02 2769 12 in in IN cord-014516-r59usk02 2769 13 more more JJR cord-014516-r59usk02 2769 14 detail detail NN cord-014516-r59usk02 2769 15 , , , cord-014516-r59usk02 2769 16 based base VBN cord-014516-r59usk02 2769 17 on on IN cord-014516-r59usk02 2769 18 the the DT cord-014516-r59usk02 2769 19 human human JJ cord-014516-r59usk02 2769 20 classification classification NN cord-014516-r59usk02 2769 21 system system NN cord-014516-r59usk02 2769 22 with with IN cord-014516-r59usk02 2769 23 a a DT cord-014516-r59usk02 2769 24 special special JJ cord-014516-r59usk02 2769 25 view view NN cord-014516-r59usk02 2769 26 on on IN cord-014516-r59usk02 2769 27 cystic cystic JJ cord-014516-r59usk02 2769 28 lesions lesion NNS cord-014516-r59usk02 2769 29 . . . cord-014516-r59usk02 2770 1 Pancreatic pancreatic JJ cord-014516-r59usk02 2770 2 masses masse NNS cord-014516-r59usk02 2770 3 sent send VBN cord-014516-r59usk02 2770 4 to to TO cord-014516-r59usk02 2770 5 LABOKLIN LABOKLIN NNP cord-014516-r59usk02 2770 6 from from IN cord-014516-r59usk02 2770 7 19 19 CD cord-014516-r59usk02 2770 8 domestic domestic JJ cord-014516-r59usk02 2770 9 cats cat NNS cord-014516-r59usk02 2770 10 ( ( -LRB- cord-014516-r59usk02 2770 11 7 7 CD cord-014516-r59usk02 2770 12 - - SYM cord-014516-r59usk02 2770 13 14 14 CD cord-014516-r59usk02 2770 14 years year NNS cord-014516-r59usk02 2770 15 ) ) -RRB- cord-014516-r59usk02 2770 16 were be VBD cord-014516-r59usk02 2770 17 investigated investigate VBN cord-014516-r59usk02 2770 18 routinely routinely RB cord-014516-r59usk02 2770 19 macroscopically macroscopically RB cord-014516-r59usk02 2770 20 and and CC cord-014516-r59usk02 2770 21 by by IN cord-014516-r59usk02 2770 22 histological histological JJ cord-014516-r59usk02 2770 23 methods method NNS cord-014516-r59usk02 2770 24 ( ( -LRB- cord-014516-r59usk02 2770 25 H.&E. h.&e. PRP$ cord-014516-r59usk02 2770 26 stain stain NN cord-014516-r59usk02 2770 27 ) ) -RRB- cord-014516-r59usk02 2770 28 . . . cord-014516-r59usk02 2771 1 The the DT cord-014516-r59usk02 2771 2 neoplasms neoplasm NNS cord-014516-r59usk02 2771 3 showed show VBD cord-014516-r59usk02 2771 4 a a DT cord-014516-r59usk02 2771 5 cystic cystic NN cord-014516-r59usk02 2771 6 ( ( -LRB- cord-014516-r59usk02 2771 7 n n NN cord-014516-r59usk02 2771 8 = = SYM cord-014516-r59usk02 2771 9 8) 8) NN cord-014516-r59usk02 2771 10 or or CC cord-014516-r59usk02 2771 11 solid solid JJ cord-014516-r59usk02 2771 12 ( ( -LRB- cord-014516-r59usk02 2771 13 n n NN cord-014516-r59usk02 2771 14 = = SYM cord-014516-r59usk02 2771 15 11 11 CD cord-014516-r59usk02 2771 16 ) ) -RRB- cord-014516-r59usk02 2771 17 pattern pattern NN cord-014516-r59usk02 2771 18 . . . cord-014516-r59usk02 2772 1 Cystic cystic JJ cord-014516-r59usk02 2772 2 pancreatic pancreatic JJ cord-014516-r59usk02 2772 3 tumors tumor NNS cord-014516-r59usk02 2772 4 were be VBD cord-014516-r59usk02 2772 5 up up RB cord-014516-r59usk02 2772 6 to to TO cord-014516-r59usk02 2772 7 7 7 CD cord-014516-r59usk02 2772 8 cm cm NNS cord-014516-r59usk02 2772 9 in in IN cord-014516-r59usk02 2772 10 diameter diameter NN cord-014516-r59usk02 2772 11 and and CC cord-014516-r59usk02 2772 12 were be VBD cord-014516-r59usk02 2772 13 classified classify VBN cord-014516-r59usk02 2772 14 as as IN cord-014516-r59usk02 2772 15 benign benign JJ cord-014516-r59usk02 2772 16 variants variant NNS cord-014516-r59usk02 2772 17 in in IN cord-014516-r59usk02 2772 18 five five CD cord-014516-r59usk02 2772 19 and and CC cord-014516-r59usk02 2772 20 malignant malignant JJ cord-014516-r59usk02 2772 21 variants variant NNS cord-014516-r59usk02 2772 22 in in IN cord-014516-r59usk02 2772 23 three three CD cord-014516-r59usk02 2772 24 cases case NNS cord-014516-r59usk02 2772 25 . . . cord-014516-r59usk02 2773 1 Based base VBN cord-014516-r59usk02 2773 2 on on IN cord-014516-r59usk02 2773 3 the the DT cord-014516-r59usk02 2773 4 human human JJ cord-014516-r59usk02 2773 5 classification classification NN cord-014516-r59usk02 2773 6 system system NN cord-014516-r59usk02 2773 7 , , , cord-014516-r59usk02 2773 8 they -PRON- PRP cord-014516-r59usk02 2773 9 were be VBD cord-014516-r59usk02 2773 10 classified classify VBN cord-014516-r59usk02 2773 11 as as IN cord-014516-r59usk02 2773 12 tubulopapillary tubulopapillary NNP cord-014516-r59usk02 2773 13 ( ( -LRB- cord-014516-r59usk02 2773 14 n n NN cord-014516-r59usk02 2773 15 = = SYM cord-014516-r59usk02 2773 16 2 2 CD cord-014516-r59usk02 2773 17 ) ) -RRB- cord-014516-r59usk02 2773 18 , , , cord-014516-r59usk02 2773 19 acinar acinar NNP cord-014516-r59usk02 2773 20 ( ( -LRB- cord-014516-r59usk02 2773 21 n n NN cord-014516-r59usk02 2773 22 = = SYM cord-014516-r59usk02 2773 23 2 2 CD cord-014516-r59usk02 2773 24 ) ) -RRB- cord-014516-r59usk02 2773 25 and and CC cord-014516-r59usk02 2773 26 mixed mixed JJ cord-014516-r59usk02 2773 27 ( ( -LRB- cord-014516-r59usk02 2773 28 n n NN cord-014516-r59usk02 2773 29 = = SYM cord-014516-r59usk02 2773 30 1 1 CD cord-014516-r59usk02 2773 31 ) ) -RRB- cord-014516-r59usk02 2773 32 adenomas adenoma NNS cord-014516-r59usk02 2773 33 and and CC cord-014516-r59usk02 2773 34 mixed mixed JJ cord-014516-r59usk02 2773 35 carcinomas carcinoma NNS cord-014516-r59usk02 2773 36 ( ( -LRB- cord-014516-r59usk02 2773 37 n n NN cord-014516-r59usk02 2773 38 = = SYM cord-014516-r59usk02 2773 39 3 3 CD cord-014516-r59usk02 2773 40 ) ) -RRB- cord-014516-r59usk02 2773 41 , , , cord-014516-r59usk02 2773 42 respectively respectively RB cord-014516-r59usk02 2773 43 . . . cord-014516-r59usk02 2774 1 Solid solid JJ cord-014516-r59usk02 2774 2 pancreatic pancreatic JJ cord-014516-r59usk02 2774 3 nodules nodule NNS cord-014516-r59usk02 2774 4 were be VBD cord-014516-r59usk02 2774 5 diagnosed diagnose VBN cord-014516-r59usk02 2774 6 as as IN cord-014516-r59usk02 2774 7 carcinomas carcinoma NNS cord-014516-r59usk02 2774 8 with with IN cord-014516-r59usk02 2774 9 a a DT cord-014516-r59usk02 2774 10 tubular tubular JJ cord-014516-r59usk02 2774 11 ( ( -LRB- cord-014516-r59usk02 2774 12 n n NN cord-014516-r59usk02 2774 13 = = SYM cord-014516-r59usk02 2774 14 5 5 CD cord-014516-r59usk02 2774 15 ) ) -RRB- cord-014516-r59usk02 2774 16 or or CC cord-014516-r59usk02 2774 17 acinar acinar NNP cord-014516-r59usk02 2774 18 ( ( -LRB- cord-014516-r59usk02 2774 19 n n NN cord-014516-r59usk02 2774 20 = = SYM cord-014516-r59usk02 2774 21 6 6 CD cord-014516-r59usk02 2774 22 ) ) -RRB- cord-014516-r59usk02 2774 23 differentiation differentiation NN cord-014516-r59usk02 2774 24 pattern pattern NN cord-014516-r59usk02 2774 25 . . . cord-014516-r59usk02 2775 1 In in IN cord-014516-r59usk02 2775 2 summary summary NN cord-014516-r59usk02 2775 3 , , , cord-014516-r59usk02 2775 4 the the DT cord-014516-r59usk02 2775 5 gross gross JJ cord-014516-r59usk02 2775 6 structure structure NN cord-014516-r59usk02 2775 7 ( ( -LRB- cord-014516-r59usk02 2775 8 solid solid JJ cord-014516-r59usk02 2775 9 versus versus IN cord-014516-r59usk02 2775 10 cystic cystic NN cord-014516-r59usk02 2775 11 ) ) -RRB- cord-014516-r59usk02 2775 12 seems seem VBZ cord-014516-r59usk02 2775 13 to to TO cord-014516-r59usk02 2775 14 be be VB cord-014516-r59usk02 2775 15 of of IN cord-014516-r59usk02 2775 16 prognostic prognostic JJ cord-014516-r59usk02 2775 17 relevance relevance NN cord-014516-r59usk02 2775 18 . . . cord-014516-r59usk02 2776 1 In in IN cord-014516-r59usk02 2776 2 contrast contrast NN cord-014516-r59usk02 2776 3 to to IN cord-014516-r59usk02 2776 4 solid solid JJ cord-014516-r59usk02 2776 5 tumors tumor NNS cord-014516-r59usk02 2776 6 , , , cord-014516-r59usk02 2776 7 cystic cystic JJ cord-014516-r59usk02 2776 8 pancreatic pancreatic JJ cord-014516-r59usk02 2776 9 lesions lesion NNS cord-014516-r59usk02 2776 10 in in IN cord-014516-r59usk02 2776 11 the the DT cord-014516-r59usk02 2776 12 cat cat NN cord-014516-r59usk02 2776 13 behave behave VBP cord-014516-r59usk02 2776 14 benign benign JJ cord-014516-r59usk02 2776 15 in in IN cord-014516-r59usk02 2776 16 a a DT cord-014516-r59usk02 2776 17 higher high JJR cord-014516-r59usk02 2776 18 percentage percentage NN cord-014516-r59usk02 2776 19 of of IN cord-014516-r59usk02 2776 20 cases case NNS cord-014516-r59usk02 2776 21 , , , cord-014516-r59usk02 2776 22 resulting result VBG cord-014516-r59usk02 2776 23 in in IN cord-014516-r59usk02 2776 24 a a DT cord-014516-r59usk02 2776 25 better well JJR cord-014516-r59usk02 2776 26 prognosis prognosis NN cord-014516-r59usk02 2776 27 . . . cord-014516-r59usk02 2777 1 Therefore therefore RB cord-014516-r59usk02 2777 2 , , , cord-014516-r59usk02 2777 3 surgical surgical JJ cord-014516-r59usk02 2777 4 excision excision NN cord-014516-r59usk02 2777 5 of of IN cord-014516-r59usk02 2777 6 these these DT cord-014516-r59usk02 2777 7 cystic cystic JJ cord-014516-r59usk02 2777 8 masses masse NNS cord-014516-r59usk02 2777 9 can can MD cord-014516-r59usk02 2777 10 be be VB cord-014516-r59usk02 2777 11 recommended recommend VBN cord-014516-r59usk02 2777 12 . . . cord-014516-r59usk02 2778 1 With with IN cord-014516-r59usk02 2778 2 respect respect NN cord-014516-r59usk02 2778 3 to to IN cord-014516-r59usk02 2778 4 the the DT cord-014516-r59usk02 2778 5 human human JJ cord-014516-r59usk02 2778 6 classification classification NN cord-014516-r59usk02 2778 7 system system NN cord-014516-r59usk02 2778 8 , , , cord-014516-r59usk02 2778 9 three three CD cord-014516-r59usk02 2778 10 different different JJ cord-014516-r59usk02 2778 11 subtypes subtype NNS cord-014516-r59usk02 2778 12 of of IN cord-014516-r59usk02 2778 13 cystic cystic JJ cord-014516-r59usk02 2778 14 pancreatic pancreatic JJ cord-014516-r59usk02 2778 15 neoplasms neoplasm NNS cord-014516-r59usk02 2778 16 were be VBD cord-014516-r59usk02 2778 17 detected detect VBN cord-014516-r59usk02 2778 18 in in IN cord-014516-r59usk02 2778 19 the the DT cord-014516-r59usk02 2778 20 cat cat NN cord-014516-r59usk02 2778 21 that that WDT cord-014516-r59usk02 2778 22 have have VBP cord-014516-r59usk02 2778 23 not not RB cord-014516-r59usk02 2778 24 been be VBN cord-014516-r59usk02 2778 25 described describe VBN cord-014516-r59usk02 2778 26 before before RB cord-014516-r59usk02 2778 27 in in IN cord-014516-r59usk02 2778 28 veterinary veterinary JJ cord-014516-r59usk02 2778 29 medicine medicine NN cord-014516-r59usk02 2778 30 : : : cord-014516-r59usk02 2778 31 tubulopapillary tubulopapillary NNP cord-014516-r59usk02 2778 32 , , , cord-014516-r59usk02 2778 33 acinar acinar NNP cord-014516-r59usk02 2778 34 and and CC cord-014516-r59usk02 2778 35 mixed mixed JJ cord-014516-r59usk02 2778 36 . . . cord-014516-r59usk02 2779 1 To to IN cord-014516-r59usk02 2779 2 best good JJS cord-014516-r59usk02 2779 3 of of IN cord-014516-r59usk02 2779 4 our -PRON- PRP$ cord-014516-r59usk02 2779 5 knowledge knowledge NN cord-014516-r59usk02 2779 6 , , , cord-014516-r59usk02 2779 7 this this DT cord-014516-r59usk02 2779 8 is be VBZ cord-014516-r59usk02 2779 9 the the DT cord-014516-r59usk02 2779 10 first first JJ cord-014516-r59usk02 2779 11 report report NN cord-014516-r59usk02 2779 12 of of IN cord-014516-r59usk02 2779 13 cystic cystic JJ cord-014516-r59usk02 2779 14 adenocarcinomas adenocarcinomas NNP cord-014516-r59usk02 2779 15 in in IN cord-014516-r59usk02 2779 16 feline feline JJ cord-014516-r59usk02 2779 17 pancreas pancrea NNS cord-014516-r59usk02 2779 18 . . . cord-014516-r59usk02 2780 1 Further further RB cord-014516-r59usk02 2780 2 corresponding correspond VBG cord-014516-r59usk02 2780 3 clinical clinical JJ cord-014516-r59usk02 2780 4 and and CC cord-014516-r59usk02 2780 5 histological histological JJ cord-014516-r59usk02 2780 6 investigations investigation NNS cord-014516-r59usk02 2780 7 are be VBP cord-014516-r59usk02 2780 8 needed need VBN cord-014516-r59usk02 2780 9 for for IN cord-014516-r59usk02 2780 10 a a DT cord-014516-r59usk02 2780 11 better well RBR cord-014516-r59usk02 2780 12 diagnostic diagnostic JJ cord-014516-r59usk02 2780 13 ( ( -LRB- cord-014516-r59usk02 2780 14 ultrasound ultrasound NN cord-014516-r59usk02 2780 15 , , , cord-014516-r59usk02 2780 16 MRI MRI NNP cord-014516-r59usk02 2780 17 ) ) -RRB- cord-014516-r59usk02 2780 18 and and CC cord-014516-r59usk02 2780 19 prognostic prognostic JJ cord-014516-r59usk02 2780 20 characterisation characterisation NN cord-014516-r59usk02 2780 21 of of IN cord-014516-r59usk02 2780 22 cystic cystic JJ cord-014516-r59usk02 2780 23 lesions lesion NNS cord-014516-r59usk02 2780 24 in in IN cord-014516-r59usk02 2780 25 feline feline JJ cord-014516-r59usk02 2780 26 pancreas pancrea NNS cord-014516-r59usk02 2780 27 . . . cord-014516-r59usk02 2781 1 No no DT cord-014516-r59usk02 2781 2 conflicts conflict NNS cord-014516-r59usk02 2781 3 of of IN cord-014516-r59usk02 2781 4 interest interest NN cord-014516-r59usk02 2781 5 reported report VBN cord-014516-r59usk02 2781 6 . . . cord-014516-r59usk02 2782 1 The the DT cord-014516-r59usk02 2782 2 immunohistochemical immunohistochemical JJ cord-014516-r59usk02 2782 3 detection detection NN cord-014516-r59usk02 2782 4 of of IN cord-014516-r59usk02 2782 5 Cyclooxygenase-2 Cyclooxygenase-2 NNP cord-014516-r59usk02 2782 6 ( ( -LRB- cord-014516-r59usk02 2782 7 Cox-2 Cox-2 NNP cord-014516-r59usk02 2782 8 ) ) -RRB- cord-014516-r59usk02 2782 9 expression expression NN cord-014516-r59usk02 2782 10 in in IN cord-014516-r59usk02 2782 11 canine canine JJ cord-014516-r59usk02 2782 12 mast mast NN cord-014516-r59usk02 2782 13 cell cell NN cord-014516-r59usk02 2782 14 tumours tumour NNS cord-014516-r59usk02 2782 15 was be VBD cord-014516-r59usk02 2782 16 recently recently RB cord-014516-r59usk02 2782 17 described describe VBN cord-014516-r59usk02 2782 18 by by IN cord-014516-r59usk02 2782 19 our -PRON- PRP$ cord-014516-r59usk02 2782 20 team team NN cord-014516-r59usk02 2782 21 ( ( -LRB- cord-014516-r59usk02 2782 22 Prada Prada NNP cord-014516-r59usk02 2782 23 et et NNP cord-014516-r59usk02 2782 24 al al NNP cord-014516-r59usk02 2782 25 . . NNP cord-014516-r59usk02 2782 26 , , , cord-014516-r59usk02 2782 27 2012 2012 CD cord-014516-r59usk02 2782 28 ) ) -RRB- cord-014516-r59usk02 2782 29 . . . cord-014516-r59usk02 2783 1 However however RB cord-014516-r59usk02 2783 2 its -PRON- PRP$ cord-014516-r59usk02 2783 3 prognostic prognostic JJ cord-014516-r59usk02 2783 4 value value NN cord-014516-r59usk02 2783 5 needs need VBZ cord-014516-r59usk02 2783 6 to to TO cord-014516-r59usk02 2783 7 be be VB cord-014516-r59usk02 2783 8 established establish VBN cord-014516-r59usk02 2783 9 . . . cord-014516-r59usk02 2784 1 The the DT cord-014516-r59usk02 2784 2 aim aim NN cord-014516-r59usk02 2784 3 of of IN cord-014516-r59usk02 2784 4 the the DT cord-014516-r59usk02 2784 5 present present JJ cord-014516-r59usk02 2784 6 work work NN cord-014516-r59usk02 2784 7 was be VBD cord-014516-r59usk02 2784 8 study study VB cord-014516-r59usk02 2784 9 the the DT cord-014516-r59usk02 2784 10 prognostic prognostic JJ cord-014516-r59usk02 2784 11 value value NN cord-014516-r59usk02 2784 12 of of IN cord-014516-r59usk02 2784 13 Cox-2 Cox-2 NNP cord-014516-r59usk02 2784 14 expression expression NN cord-014516-r59usk02 2784 15 by by IN cord-014516-r59usk02 2784 16 investigating investigate VBG cord-014516-r59usk02 2784 17 the the DT cord-014516-r59usk02 2784 18 relationship relationship NN cord-014516-r59usk02 2784 19 with with IN cord-014516-r59usk02 2784 20 several several JJ cord-014516-r59usk02 2784 21 clinical clinical JJ cord-014516-r59usk02 2784 22 and and CC cord-014516-r59usk02 2784 23 pathological pathological JJ cord-014516-r59usk02 2784 24 variables variable NNS cord-014516-r59usk02 2784 25 including include VBG cord-014516-r59usk02 2784 26 the the DT cord-014516-r59usk02 2784 27 Overall Overall NNP cord-014516-r59usk02 2784 28 Survival Survival NNP cord-014516-r59usk02 2784 29 ( ( -LRB- cord-014516-r59usk02 2784 30 OS OS NNP cord-014516-r59usk02 2784 31 ) ) -RRB- cord-014516-r59usk02 2784 32 time time NN cord-014516-r59usk02 2784 33 . . . cord-014516-r59usk02 2785 1 We -PRON- PRP cord-014516-r59usk02 2785 2 included include VBD cord-014516-r59usk02 2785 3 57 57 CD cord-014516-r59usk02 2785 4 dogs dog NNS cord-014516-r59usk02 2785 5 with with IN cord-014516-r59usk02 2785 6 mast mast JJ cord-014516-r59usk02 2785 7 cell cell NN cord-014516-r59usk02 2785 8 tumours tumour NNS cord-014516-r59usk02 2785 9 ( ( -LRB- cord-014516-r59usk02 2785 10 18 18 CD cord-014516-r59usk02 2785 11 grade grade NN cord-014516-r59usk02 2785 12 I I NNP cord-014516-r59usk02 2785 13 ; ; : cord-014516-r59usk02 2785 14 21 21 CD cord-014516-r59usk02 2785 15 grade grade NN cord-014516-r59usk02 2785 16 II II NNP cord-014516-r59usk02 2785 17 and and CC cord-014516-r59usk02 2785 18 18 18 CD cord-014516-r59usk02 2785 19 grade grade NN cord-014516-r59usk02 2785 20 III III NNP cord-014516-r59usk02 2785 21 ) ) -RRB- cord-014516-r59usk02 2785 22 . . . cord-014516-r59usk02 2786 1 Cox-2 Cox-2 NNP cord-014516-r59usk02 2786 2 immunohistochemical immunohistochemical JJ cord-014516-r59usk02 2786 3 expression expression NN cord-014516-r59usk02 2786 4 was be VBD cord-014516-r59usk02 2786 5 carried carry VBN cord-014516-r59usk02 2786 6 out out RP cord-014516-r59usk02 2786 7 by by IN cord-014516-r59usk02 2786 8 a a DT cord-014516-r59usk02 2786 9 streptavidin streptavidin NN cord-014516-r59usk02 2786 10 - - HYPH cord-014516-r59usk02 2786 11 biotin biotin NN cord-014516-r59usk02 2786 12 method method NN cord-014516-r59usk02 2786 13 . . . cord-014516-r59usk02 2787 1 For for IN cord-014516-r59usk02 2787 2 the the DT cord-014516-r59usk02 2787 3 Cox-2 Cox-2 NNP cord-014516-r59usk02 2787 4 immunoreactivity immunoreactivity NN cord-014516-r59usk02 2787 5 evaluation evaluation NN cord-014516-r59usk02 2787 6 were be VBD cord-014516-r59usk02 2787 7 considered consider VBN cord-014516-r59usk02 2787 8 the the DT cord-014516-r59usk02 2787 9 number number NN cord-014516-r59usk02 2787 10 of of IN cord-014516-r59usk02 2787 11 positive positive JJ cord-014516-r59usk02 2787 12 cells cell NNS cord-014516-r59usk02 2787 13 ( ( -LRB- cord-014516-r59usk02 2787 14 Cox-2 Cox-2 NNP cord-014516-r59usk02 2787 15 extension extension NN cord-014516-r59usk02 2787 16 ) ) -RRB- cord-014516-r59usk02 2787 17 , , , cord-014516-r59usk02 2787 18 the the DT cord-014516-r59usk02 2787 19 intensity intensity NN cord-014516-r59usk02 2787 20 and and CC cord-014516-r59usk02 2787 21 the the DT cord-014516-r59usk02 2787 22 score score NN cord-014516-r59usk02 2787 23 of of IN cord-014516-r59usk02 2787 24 Cox-2 Cox-2 NNP cord-014516-r59usk02 2787 25 . . . cord-014516-r59usk02 2788 1 The the DT cord-014516-r59usk02 2788 2 following follow VBG cord-014516-r59usk02 2788 3 clinical clinical JJ cord-014516-r59usk02 2788 4 and and CC cord-014516-r59usk02 2788 5 pathological pathological JJ cord-014516-r59usk02 2788 6 features feature NNS cord-014516-r59usk02 2788 7 were be VBD cord-014516-r59usk02 2788 8 considered consider VBN cord-014516-r59usk02 2788 9 : : : cord-014516-r59usk02 2788 10 animal animal NN cord-014516-r59usk02 2788 11 age age NN cord-014516-r59usk02 2788 12 , , , cord-014516-r59usk02 2788 13 sex sex NN cord-014516-r59usk02 2788 14 , , , cord-014516-r59usk02 2788 15 tumour tumour NN cord-014516-r59usk02 2788 16 anatomical anatomical JJ cord-014516-r59usk02 2788 17 location location NN cord-014516-r59usk02 2788 18 , , , cord-014516-r59usk02 2788 19 tumour tumour NN cord-014516-r59usk02 2788 20 size size NN cord-014516-r59usk02 2788 21 , , , cord-014516-r59usk02 2788 22 skin skin NN cord-014516-r59usk02 2788 23 ulceration ulceration NN cord-014516-r59usk02 2788 24 , , , cord-014516-r59usk02 2788 25 histological histological JJ cord-014516-r59usk02 2788 26 grade grade NN cord-014516-r59usk02 2788 27 , , , cord-014516-r59usk02 2788 28 histological histological JJ cord-014516-r59usk02 2788 29 safety safety NN cord-014516-r59usk02 2788 30 margins margin NNS cord-014516-r59usk02 2788 31 and and CC cord-014516-r59usk02 2788 32 number number NN cord-014516-r59usk02 2788 33 of of IN cord-014516-r59usk02 2788 34 mitosis mitosis NN cord-014516-r59usk02 2788 35 . . . cord-014516-r59usk02 2789 1 Cox-2 Cox-2 NNP cord-014516-r59usk02 2789 2 expression expression NN cord-014516-r59usk02 2789 3 was be VBD cord-014516-r59usk02 2789 4 correlated correlate VBN cord-014516-r59usk02 2789 5 with with IN cord-014516-r59usk02 2789 6 the the DT cord-014516-r59usk02 2789 7 clinical clinical JJ cord-014516-r59usk02 2789 8 and and CC cord-014516-r59usk02 2789 9 pathological pathological JJ cord-014516-r59usk02 2789 10 data datum NNS cord-014516-r59usk02 2789 11 and and CC cord-014516-r59usk02 2789 12 with with IN cord-014516-r59usk02 2789 13 the the DT cord-014516-r59usk02 2789 14 overall overall JJ cord-014516-r59usk02 2789 15 survival survival NN cord-014516-r59usk02 2789 16 . . . cord-014516-r59usk02 2790 1 Cox-2 Cox-2 NNP cord-014516-r59usk02 2790 2 intensity intensity NN cord-014516-r59usk02 2790 3 was be VBD cord-014516-r59usk02 2790 4 statistical statistical JJ cord-014516-r59usk02 2790 5 significantly significantly RB cord-014516-r59usk02 2790 6 associated associate VBN cord-014516-r59usk02 2790 7 with with IN cord-014516-r59usk02 2790 8 skin skin NN cord-014516-r59usk02 2790 9 ulceration ulceration NN cord-014516-r59usk02 2790 10 ( ( -LRB- cord-014516-r59usk02 2790 11 p p NN cord-014516-r59usk02 2790 12 = = SYM cord-014516-r59usk02 2790 13 0,009 0,009 CD cord-014516-r59usk02 2790 14 ) ) -RRB- cord-014516-r59usk02 2790 15 ; ; : cord-014516-r59usk02 2790 16 histological histological JJ cord-014516-r59usk02 2790 17 grade grade NN cord-014516-r59usk02 2790 18 ( ( -LRB- cord-014516-r59usk02 2790 19 p p NN cord-014516-r59usk02 2790 20 = = SYM cord-014516-r59usk02 2790 21 0,006 0,006 CD cord-014516-r59usk02 2790 22 ) ) -RRB- cord-014516-r59usk02 2790 23 and and CC cord-014516-r59usk02 2790 24 absence absence NN cord-014516-r59usk02 2790 25 of of IN cord-014516-r59usk02 2790 26 histological histological JJ cord-014516-r59usk02 2790 27 safety safety NN cord-014516-r59usk02 2790 28 margins margin NNS cord-014516-r59usk02 2790 29 ( ( -LRB- cord-014516-r59usk02 2790 30 p p NN cord-014516-r59usk02 2790 31 = = SYM cord-014516-r59usk02 2790 32 0,043 0,043 CD cord-014516-r59usk02 2790 33 ) ) -RRB- cord-014516-r59usk02 2790 34 , , , cord-014516-r59usk02 2790 35 high high JJ cord-014516-r59usk02 2790 36 mitotic mitotic JJ cord-014516-r59usk02 2790 37 number number NN cord-014516-r59usk02 2790 38 ( ( -LRB- cord-014516-r59usk02 2790 39 p p NN cord-014516-r59usk02 2790 40 = = SYM cord-014516-r59usk02 2790 41 0,024 0,024 CD cord-014516-r59usk02 2790 42 ) ) -RRB- cord-014516-r59usk02 2790 43 and and CC cord-014516-r59usk02 2790 44 with with IN cord-014516-r59usk02 2790 45 overall overall JJ cord-014516-r59usk02 2790 46 survival survival NN cord-014516-r59usk02 2790 47 ( ( -LRB- cord-014516-r59usk02 2790 48 p p NN cord-014516-r59usk02 2790 49 = = SYM cord-014516-r59usk02 2790 50 0,02 0,02 NNP cord-014516-r59usk02 2790 51 ) ) -RRB- cord-014516-r59usk02 2790 52 . . . cord-014516-r59usk02 2791 1 Both both DT cord-014516-r59usk02 2791 2 Cox-2 Cox-2 NNP cord-014516-r59usk02 2791 3 extension extension NN cord-014516-r59usk02 2791 4 and and CC cord-014516-r59usk02 2791 5 Cox-2 Cox-2 NNP cord-014516-r59usk02 2791 6 immunohistochemical immunohistochemical JJ cord-014516-r59usk02 2791 7 score score NN cord-014516-r59usk02 2791 8 present present JJ cord-014516-r59usk02 2791 9 no no DT cord-014516-r59usk02 2791 10 statistical statistical JJ cord-014516-r59usk02 2791 11 relationship relationship NN cord-014516-r59usk02 2791 12 with with IN cord-014516-r59usk02 2791 13 the the DT cord-014516-r59usk02 2791 14 variables variable NNS cord-014516-r59usk02 2791 15 considered consider VBN cord-014516-r59usk02 2791 16 neither neither CC cord-014516-r59usk02 2791 17 with with IN cord-014516-r59usk02 2791 18 the the DT cord-014516-r59usk02 2791 19 overall overall JJ cord-014516-r59usk02 2791 20 survival survival NN cord-014516-r59usk02 2791 21 . . . cord-014516-r59usk02 2792 1 Our -PRON- PRP$ cord-014516-r59usk02 2792 2 results result NNS cord-014516-r59usk02 2792 3 suggest suggest VBP cord-014516-r59usk02 2792 4 that that IN cord-014516-r59usk02 2792 5 Cox-2 Cox-2 NNP cord-014516-r59usk02 2792 6 have have VBP cord-014516-r59usk02 2792 7 an an DT cord-014516-r59usk02 2792 8 important important JJ cord-014516-r59usk02 2792 9 role role NN cord-014516-r59usk02 2792 10 in in IN cord-014516-r59usk02 2792 11 dog dog NN cord-014516-r59usk02 2792 12 mast mast NN cord-014516-r59usk02 2792 13 cell cell NN cord-014516-r59usk02 2792 14 tumours tumour NNS cord-014516-r59usk02 2792 15 progression progression NN cord-014516-r59usk02 2792 16 and and CC cord-014516-r59usk02 2792 17 could could MD cord-014516-r59usk02 2792 18 constitute constitute VB cord-014516-r59usk02 2792 19 a a DT cord-014516-r59usk02 2792 20 promising promising JJ cord-014516-r59usk02 2792 21 therapeutic therapeutic JJ cord-014516-r59usk02 2792 22 target target NN cord-014516-r59usk02 2792 23 in in IN cord-014516-r59usk02 2792 24 this this DT cord-014516-r59usk02 2792 25 neoplasia neoplasia NN cord-014516-r59usk02 2792 26 . . . cord-014516-r59usk02 2793 1 However however RB cord-014516-r59usk02 2793 2 , , , cord-014516-r59usk02 2793 3 our -PRON- PRP$ cord-014516-r59usk02 2793 4 study study NN cord-014516-r59usk02 2793 5 also also RB cord-014516-r59usk02 2793 6 demonstrated demonstrate VBD cord-014516-r59usk02 2793 7 that that IN cord-014516-r59usk02 2793 8 in in IN cord-014516-r59usk02 2793 9 MCTs MCTs NNP cord-014516-r59usk02 2793 10 , , , cord-014516-r59usk02 2793 11 is be VBZ cord-014516-r59usk02 2793 12 the the DT cord-014516-r59usk02 2793 13 Cox-2 Cox-2 NNP cord-014516-r59usk02 2793 14 intensity intensity NN cord-014516-r59usk02 2793 15 that that WDT cord-014516-r59usk02 2793 16 has have VBZ cord-014516-r59usk02 2793 17 the the DT cord-014516-r59usk02 2793 18 prognostic prognostic JJ cord-014516-r59usk02 2793 19 value value NN cord-014516-r59usk02 2793 20 , , , cord-014516-r59usk02 2793 21 not not RB cord-014516-r59usk02 2793 22 the the DT cord-014516-r59usk02 2793 23 number number NN cord-014516-r59usk02 2793 24 of of IN cord-014516-r59usk02 2793 25 Cox-2 Cox-2 NNP cord-014516-r59usk02 2793 26 positive positive JJ cord-014516-r59usk02 2793 27 cells cell NNS cord-014516-r59usk02 2793 28 ( ( -LRB- cord-014516-r59usk02 2793 29 Cox-2 Cox-2 NNP cord-014516-r59usk02 2793 30 extension extension NN cord-014516-r59usk02 2793 31 ) ) -RRB- cord-014516-r59usk02 2793 32 and and CC cord-014516-r59usk02 2793 33 not not RB cord-014516-r59usk02 2793 34 the the DT cord-014516-r59usk02 2793 35 Cox-2 Cox-2 NNP cord-014516-r59usk02 2793 36 immunohistochemical immunohistochemical JJ cord-014516-r59usk02 2793 37 score score NN cord-014516-r59usk02 2793 38 . . . cord-014516-r59usk02 2794 1 Consequently consequently RB cord-014516-r59usk02 2794 2 , , , cord-014516-r59usk02 2794 3 Cox-2 Cox-2 NNP cord-014516-r59usk02 2794 4 intensity intensity NN cord-014516-r59usk02 2794 5 should should MD cord-014516-r59usk02 2794 6 be be VB cord-014516-r59usk02 2794 7 elected elect VBN cord-014516-r59usk02 2794 8 for for IN cord-014516-r59usk02 2794 9 evaluating evaluate VBG cord-014516-r59usk02 2794 10 the the DT cord-014516-r59usk02 2794 11 Cox-2 Cox-2 NNP cord-014516-r59usk02 2794 12 positivity positivity NN cord-014516-r59usk02 2794 13 in in IN cord-014516-r59usk02 2794 14 MCTs MCTs NNP cord-014516-r59usk02 2794 15 immunohistochemical immunohistochemical JJ cord-014516-r59usk02 2794 16 studies study NNS cord-014516-r59usk02 2794 17 . . . cord-014516-r59usk02 2795 1 Merial merial JJ cord-014516-r59usk02 2795 2 provided provide VBN cord-014516-r59usk02 2795 3 financial financial JJ cord-014516-r59usk02 2795 4 support support NN cord-014516-r59usk02 2795 5 for for IN cord-014516-r59usk02 2795 6 immunohistochemical immunohistochemical JJ cord-014516-r59usk02 2795 7 analayis analayis NNP cord-014516-r59usk02 2795 8 . . . cord-014516-r59usk02 2796 1 The the DT cord-014516-r59usk02 2796 2 research research NN cord-014516-r59usk02 2796 3 centres centre NNS cord-014516-r59usk02 2796 4 has have VBZ cord-014516-r59usk02 2796 5 also also RB cord-014516-r59usk02 2796 6 received receive VBN cord-014516-r59usk02 2796 7 financial financial JJ cord-014516-r59usk02 2796 8 suppoprt suppoprt NN cord-014516-r59usk02 2796 9 from from IN cord-014516-r59usk02 2796 10 CECAV CECAV NNP cord-014516-r59usk02 2796 11 , , , cord-014516-r59usk02 2796 12 CECA CECA NNP cord-014516-r59usk02 2796 13 and and CC cord-014516-r59usk02 2796 14 CITAB CITAB NNP cord-014516-r59usk02 2796 15 . . . cord-014516-r59usk02 2797 1 Dogs dog NNS cord-014516-r59usk02 2797 2 which which WDT cord-014516-r59usk02 2797 3 were be VBD cord-014516-r59usk02 2797 4 radiated radiate VBN cord-014516-r59usk02 2797 5 for for IN cord-014516-r59usk02 2797 6 a a DT cord-014516-r59usk02 2797 7 subcutaneous subcutaneous JJ cord-014516-r59usk02 2797 8 sarcoma sarcoma NN cord-014516-r59usk02 2797 9 between between IN cord-014516-r59usk02 2797 10 2006 2006 CD cord-014516-r59usk02 2797 11 and and CC cord-014516-r59usk02 2797 12 2011 2011 CD cord-014516-r59usk02 2797 13 were be VBD cord-014516-r59usk02 2797 14 included include VBN cord-014516-r59usk02 2797 15 . . . cord-014516-r59usk02 2798 1 Medical medical JJ cord-014516-r59usk02 2798 2 records record NNS cord-014516-r59usk02 2798 3 were be VBD cord-014516-r59usk02 2798 4 reviewed review VBN cord-014516-r59usk02 2798 5 and and CC cord-014516-r59usk02 2798 6 patient patient JJ cord-014516-r59usk02 2798 7 characteristics characteristic NNS cord-014516-r59usk02 2798 8 , , , cord-014516-r59usk02 2798 9 treatment treatment NN cord-014516-r59usk02 2798 10 protocols protocol NNS cord-014516-r59usk02 2798 11 , , , cord-014516-r59usk02 2798 12 adjuvant adjuvant JJ cord-014516-r59usk02 2798 13 therapies therapy NNS cord-014516-r59usk02 2798 14 and and CC cord-014516-r59usk02 2798 15 outcome outcome NN cord-014516-r59usk02 2798 16 were be VBD cord-014516-r59usk02 2798 17 analysed analyse VBN cord-014516-r59usk02 2798 18 . . . cord-014516-r59usk02 2799 1 Follow follow VB cord-014516-r59usk02 2799 2 - - HYPH cord-014516-r59usk02 2799 3 up up RP cord-014516-r59usk02 2799 4 information information NN cord-014516-r59usk02 2799 5 was be VBD cord-014516-r59usk02 2799 6 obtained obtain VBN cord-014516-r59usk02 2799 7 from from IN cord-014516-r59usk02 2799 8 medical medical JJ cord-014516-r59usk02 2799 9 records record NNS cord-014516-r59usk02 2799 10 and and CC cord-014516-r59usk02 2799 11 by by IN cord-014516-r59usk02 2799 12 phone phone NN cord-014516-r59usk02 2799 13 conversations conversation NNS cord-014516-r59usk02 2799 14 with with IN cord-014516-r59usk02 2799 15 veterinarians veterinarian NNS cord-014516-r59usk02 2799 16 or or CC cord-014516-r59usk02 2799 17 pet pet JJ cord-014516-r59usk02 2799 18 owners owner NNS cord-014516-r59usk02 2799 19 . . . cord-014516-r59usk02 2800 1 Thirty thirty CD cord-014516-r59usk02 2800 2 - - HYPH cord-014516-r59usk02 2800 3 two two CD cord-014516-r59usk02 2800 4 dogs dog NNS cord-014516-r59usk02 2800 5 were be VBD cord-014516-r59usk02 2800 6 included include VBN cord-014516-r59usk02 2800 7 into into IN cord-014516-r59usk02 2800 8 this this DT cord-014516-r59usk02 2800 9 study study NN cord-014516-r59usk02 2800 10 . . . cord-014516-r59usk02 2801 1 Mean mean JJ cord-014516-r59usk02 2801 2 age age NN cord-014516-r59usk02 2801 3 was be VBD cord-014516-r59usk02 2801 4 9 9 CD cord-014516-r59usk02 2801 5 years year NNS cord-014516-r59usk02 2801 6 and and CC cord-014516-r59usk02 2801 7 mean mean VB cord-014516-r59usk02 2801 8 body body NN cord-014516-r59usk02 2801 9 - - HYPH cord-014516-r59usk02 2801 10 weight weight NN cord-014516-r59usk02 2801 11 was be VBD cord-014516-r59usk02 2801 12 32 32 CD cord-014516-r59usk02 2801 13 kg kg NNS cord-014516-r59usk02 2801 14 . . . cord-014516-r59usk02 2802 1 Male male JJ cord-014516-r59usk02 2802 2 dogs dog NNS cord-014516-r59usk02 2802 3 were be VBD cord-014516-r59usk02 2802 4 slightly slightly RB cord-014516-r59usk02 2802 5 overrepresented overrepresented JJ cord-014516-r59usk02 2802 6 ( ( -LRB- cord-014516-r59usk02 2802 7 59.4 59.4 CD cord-014516-r59usk02 2802 8 % % NN cord-014516-r59usk02 2802 9 ) ) -RRB- cord-014516-r59usk02 2802 10 . . . cord-014516-r59usk02 2803 1 Curative curative JJ cord-014516-r59usk02 2803 2 intent intent NN cord-014516-r59usk02 2803 3 radiotherapy radiotherapy NN cord-014516-r59usk02 2803 4 was be VBD cord-014516-r59usk02 2803 5 applied apply VBN cord-014516-r59usk02 2803 6 in in IN cord-014516-r59usk02 2803 7 22 22 CD cord-014516-r59usk02 2803 8 dogs dog NNS cord-014516-r59usk02 2803 9 and and CC cord-014516-r59usk02 2803 10 palliative palliative JJ cord-014516-r59usk02 2803 11 intent intent NN cord-014516-r59usk02 2803 12 in in IN cord-014516-r59usk02 2803 13 10 10 CD cord-014516-r59usk02 2803 14 dogs dog NNS cord-014516-r59usk02 2803 15 with with IN cord-014516-r59usk02 2803 16 a a DT cord-014516-r59usk02 2803 17 mean mean JJ cord-014516-r59usk02 2803 18 total total JJ cord-014516-r59usk02 2803 19 dose dose NN cord-014516-r59usk02 2803 20 of of IN cord-014516-r59usk02 2803 21 51 51 CD cord-014516-r59usk02 2803 22 and and CC cord-014516-r59usk02 2803 23 28.4 28.4 CD cord-014516-r59usk02 2803 24 Gray Gray NNP cord-014516-r59usk02 2803 25 , , , cord-014516-r59usk02 2803 26 respectively respectively RB cord-014516-r59usk02 2803 27 . . . cord-014516-r59usk02 2804 1 In in IN cord-014516-r59usk02 2804 2 17 17 CD cord-014516-r59usk02 2804 3 dogs dog NNS cord-014516-r59usk02 2804 4 microscopic microscopic JJ cord-014516-r59usk02 2804 5 disease disease NN cord-014516-r59usk02 2804 6 was be VBD cord-014516-r59usk02 2804 7 radiated radiate VBN cord-014516-r59usk02 2804 8 . . . cord-014516-r59usk02 2805 1 Five five CD cord-014516-r59usk02 2805 2 dogs dog NNS cord-014516-r59usk02 2805 3 received receive VBD cord-014516-r59usk02 2805 4 liposomal liposomal JJ cord-014516-r59usk02 2805 5 doxorubicin doxorubicin NN cord-014516-r59usk02 2805 6 concomitantly concomitantly RB cord-014516-r59usk02 2805 7 with with IN cord-014516-r59usk02 2805 8 radiotherapy radiotherapy NN cord-014516-r59usk02 2805 9 , , , cord-014516-r59usk02 2805 10 two two CD cord-014516-r59usk02 2805 11 received receive VBN cord-014516-r59usk02 2805 12 adjuvant adjuvant JJ cord-014516-r59usk02 2805 13 doxorubicin doxorubicin NN cord-014516-r59usk02 2805 14 and and CC cord-014516-r59usk02 2805 15 one one CD cord-014516-r59usk02 2805 16 intralesional intralesional JJ cord-014516-r59usk02 2805 17 cisplatin cisplatin NN cord-014516-r59usk02 2805 18 . . . cord-014516-r59usk02 2806 1 Overall overall JJ cord-014516-r59usk02 2806 2 median median JJ cord-014516-r59usk02 2806 3 survival survival NN cord-014516-r59usk02 2806 4 time time NN cord-014516-r59usk02 2806 5 was be VBD cord-014516-r59usk02 2806 6 914 914 CD cord-014516-r59usk02 2806 7 days day NNS cord-014516-r59usk02 2806 8 with with IN cord-014516-r59usk02 2806 9 curative curative JJ cord-014516-r59usk02 2806 10 and and CC cord-014516-r59usk02 2806 11 513 513 CD cord-014516-r59usk02 2806 12 days day NNS cord-014516-r59usk02 2806 13 with with IN cord-014516-r59usk02 2806 14 palliative palliative JJ cord-014516-r59usk02 2806 15 treatment treatment NN cord-014516-r59usk02 2806 16 . . . cord-014516-r59usk02 2807 1 Overall overall JJ cord-014516-r59usk02 2807 2 median median JJ cord-014516-r59usk02 2807 3 survival survival NN cord-014516-r59usk02 2807 4 time time NN cord-014516-r59usk02 2807 5 in in IN cord-014516-r59usk02 2807 6 dogs dog NNS cord-014516-r59usk02 2807 7 with with IN cord-014516-r59usk02 2807 8 macroscopic macroscopic JJ cord-014516-r59usk02 2807 9 disease disease NN cord-014516-r59usk02 2807 10 was be VBD cord-014516-r59usk02 2807 11 369 369 CD cord-014516-r59usk02 2807 12 days day NNS cord-014516-r59usk02 2807 13 and and CC cord-014516-r59usk02 2807 14 in in IN cord-014516-r59usk02 2807 15 patients patient NNS cord-014516-r59usk02 2807 16 with with IN cord-014516-r59usk02 2807 17 microscopic microscopic JJ cord-014516-r59usk02 2807 18 disease disease NN cord-014516-r59usk02 2807 19 it -PRON- PRP cord-014516-r59usk02 2807 20 was be VBD cord-014516-r59usk02 2807 21 not not RB cord-014516-r59usk02 2807 22 reached reach VBN cord-014516-r59usk02 2807 23 . . . cord-014516-r59usk02 2808 1 Radiotherapy radiotherapy NN cord-014516-r59usk02 2808 2 was be VBD cord-014516-r59usk02 2808 3 generally generally RB cord-014516-r59usk02 2808 4 accepted accept VBN cord-014516-r59usk02 2808 5 as as IN cord-014516-r59usk02 2808 6 new new JJ cord-014516-r59usk02 2808 7 treatment treatment NN cord-014516-r59usk02 2808 8 modality modality NN cord-014516-r59usk02 2808 9 by by IN cord-014516-r59usk02 2808 10 pet pet JJ cord-014516-r59usk02 2808 11 owners owner NNS cord-014516-r59usk02 2808 12 and and CC cord-014516-r59usk02 2808 13 referring refer VBG cord-014516-r59usk02 2808 14 veterinarians veterinarian NNS cord-014516-r59usk02 2808 15 . . . cord-014516-r59usk02 2809 1 Comparable comparable JJ cord-014516-r59usk02 2809 2 to to IN cord-014516-r59usk02 2809 3 the the DT cord-014516-r59usk02 2809 4 literature literature NN cord-014516-r59usk02 2809 5 , , , cord-014516-r59usk02 2809 6 best good JJS cord-014516-r59usk02 2809 7 outcome outcome NN cord-014516-r59usk02 2809 8 was be VBD cord-014516-r59usk02 2809 9 achieved achieve VBN cord-014516-r59usk02 2809 10 for for IN cord-014516-r59usk02 2809 11 dogs dog NNS cord-014516-r59usk02 2809 12 radiated radiate VBN cord-014516-r59usk02 2809 13 with with IN cord-014516-r59usk02 2809 14 microscopic microscopic JJ cord-014516-r59usk02 2809 15 disease disease NN cord-014516-r59usk02 2809 16 Conflicts conflict NNS cord-014516-r59usk02 2809 17 of of IN cord-014516-r59usk02 2809 18 interest interest NN cord-014516-r59usk02 2809 19 : : : cord-014516-r59usk02 2809 20 No no DT cord-014516-r59usk02 2809 21 conflicts conflict NNS cord-014516-r59usk02 2809 22 of of IN cord-014516-r59usk02 2809 23 interest interest NN cord-014516-r59usk02 2809 24 reported report VBN cord-014516-r59usk02 2809 25 . . . cord-014516-r59usk02 2810 1 Oncept Oncept NNP cord-014516-r59usk02 2810 2 â â CD cord-014516-r59usk02 2810 3 , , , cord-014516-r59usk02 2810 4 is be VBZ cord-014516-r59usk02 2810 5 indicated indicate VBN cord-014516-r59usk02 2810 6 for for IN cord-014516-r59usk02 2810 7 the the DT cord-014516-r59usk02 2810 8 treatment treatment NN cord-014516-r59usk02 2810 9 of of IN cord-014516-r59usk02 2810 10 stage stage NN cord-014516-r59usk02 2810 11 II II NNP cord-014516-r59usk02 2810 12 or or CC cord-014516-r59usk02 2810 13 III iii CD cord-014516-r59usk02 2810 14 oral oral JJ cord-014516-r59usk02 2810 15 melanoma melanoma NN cord-014516-r59usk02 2810 16 after after IN cord-014516-r59usk02 2810 17 local local JJ cord-014516-r59usk02 2810 18 control control NN cord-014516-r59usk02 2810 19 with with IN cord-014516-r59usk02 2810 20 survival survival NN cord-014516-r59usk02 2810 21 times time NNS cord-014516-r59usk02 2810 22 significantly significantly RB cord-014516-r59usk02 2810 23 increased increase VBD cord-014516-r59usk02 2810 24 following follow VBG cord-014516-r59usk02 2810 25 vaccination vaccination NN cord-014516-r59usk02 2810 26 . . . cord-014516-r59usk02 2811 1 A a DT cord-014516-r59usk02 2811 2 similar similar JJ cord-014516-r59usk02 2811 3 improvement improvement NN cord-014516-r59usk02 2811 4 in in IN cord-014516-r59usk02 2811 5 survival survival NN cord-014516-r59usk02 2811 6 times time NNS cord-014516-r59usk02 2811 7 has have VBZ cord-014516-r59usk02 2811 8 also also RB cord-014516-r59usk02 2811 9 been be VBN cord-014516-r59usk02 2811 10 reported report VBN cord-014516-r59usk02 2811 11 with with IN cord-014516-r59usk02 2811 12 digit digit NN cord-014516-r59usk02 2811 13 melanoma melanoma NN cord-014516-r59usk02 2811 14 . . . cord-014516-r59usk02 2812 1 Medical medical JJ cord-014516-r59usk02 2812 2 records record NNS cord-014516-r59usk02 2812 3 of of IN cord-014516-r59usk02 2812 4 dogs dog NNS cord-014516-r59usk02 2812 5 diagnosed diagnose VBN cord-014516-r59usk02 2812 6 with with IN cord-014516-r59usk02 2812 7 melanoma melanoma NN cord-014516-r59usk02 2812 8 between between IN cord-014516-r59usk02 2812 9 March March NNP cord-014516-r59usk02 2812 10 2009 2009 CD cord-014516-r59usk02 2812 11 and and CC cord-014516-r59usk02 2812 12 December December NNP cord-014516-r59usk02 2812 13 2013 2013 CD cord-014516-r59usk02 2812 14 were be VBD cord-014516-r59usk02 2812 15 retrospectively retrospectively RB cord-014516-r59usk02 2812 16 evaluated evaluate VBN cord-014516-r59usk02 2812 17 . . . cord-014516-r59usk02 2813 1 Inclusion inclusion NN cord-014516-r59usk02 2813 2 criteria criterion NNS cord-014516-r59usk02 2813 3 were be VBD cord-014516-r59usk02 2813 4 a a DT cord-014516-r59usk02 2813 5 histopathological histopathological JJ cord-014516-r59usk02 2813 6 diagnosis diagnosis NN cord-014516-r59usk02 2813 7 of of IN cord-014516-r59usk02 2813 8 melanoma melanoma NN cord-014516-r59usk02 2813 9 , , , cord-014516-r59usk02 2813 10 surgical surgical JJ cord-014516-r59usk02 2813 11 excision excision NN cord-014516-r59usk02 2813 12 of of IN cord-014516-r59usk02 2813 13 the the DT cord-014516-r59usk02 2813 14 tumour tumour NN cord-014516-r59usk02 2813 15 , , , cord-014516-r59usk02 2813 16 and and CC cord-014516-r59usk02 2813 17 vaccination vaccination NN cord-014516-r59usk02 2813 18 using use VBG cord-014516-r59usk02 2813 19 the the DT cord-014516-r59usk02 2813 20 Oncept Oncept NNP cord-014516-r59usk02 2813 21 â â CD cord-014516-r59usk02 2813 22 vaccine vaccine NN cord-014516-r59usk02 2813 23 . . . cord-014516-r59usk02 2814 1 34 34 CD cord-014516-r59usk02 2814 2 dogs dog NNS cord-014516-r59usk02 2814 3 met meet VBD cord-014516-r59usk02 2814 4 the the DT cord-014516-r59usk02 2814 5 inclusion inclusion NN cord-014516-r59usk02 2814 6 criteria criterion NNS cord-014516-r59usk02 2814 7 . . . cord-014516-r59usk02 2815 1 nificant nificant JJ cord-014516-r59usk02 2815 2 renal renal JJ cord-014516-r59usk02 2815 3 involvement involvement NN cord-014516-r59usk02 2815 4 in in IN cord-014516-r59usk02 2815 5 dogs dog NNS cord-014516-r59usk02 2815 6 with with IN cord-014516-r59usk02 2815 7 CVL CVL NNP cord-014516-r59usk02 2815 8 . . . cord-014516-r59usk02 2816 1 This this DT cord-014516-r59usk02 2816 2 result result NN cord-014516-r59usk02 2816 3 indicates indicate VBZ cord-014516-r59usk02 2816 4 Staffordshire Staffordshire NNP cord-014516-r59usk02 2816 5 terrier terrier NN cord-014516-r59usk02 2816 6 ( ( -LRB- cord-014516-r59usk02 2816 7 2 2 CD cord-014516-r59usk02 2816 8 ) ) -RRB- cord-014516-r59usk02 2816 9 , , , cord-014516-r59usk02 2816 10 Bouvier Bouvier NNP cord-014516-r59usk02 2816 11 , , , cord-014516-r59usk02 2816 12 Giant Giant NNP cord-014516-r59usk02 2816 13 Schnauzer Schnauzer NNP cord-014516-r59usk02 2816 14 , , , cord-014516-r59usk02 2816 15 Maltese Maltese NNP cord-014516-r59usk02 2816 16 , , , cord-014516-r59usk02 2816 17 Irish irish JJ cord-014516-r59usk02 2816 18 setter setter NN cord-014516-r59usk02 2816 19 , , , cord-014516-r59usk02 2816 20 Kerry Kerry NNP cord-014516-r59usk02 2816 21 blue blue JJ cord-014516-r59usk02 2816 22 terrier terrier NNP cord-014516-r59usk02 2816 23 , , , cord-014516-r59usk02 2816 24 Golden golden JJ cord-014516-r59usk02 2816 25 retriever retriever NN cord-014516-r59usk02 2816 26 , , , cord-014516-r59usk02 2816 27 Scottish scottish JJ cord-014516-r59usk02 2816 28 terrier terrier NN cord-014516-r59usk02 2816 29 , , , cord-014516-r59usk02 2816 30 and and CC cord-014516-r59usk02 2816 31 Great Great NNP cord-014516-r59usk02 2816 32 Dane Dane NNP cord-014516-r59usk02 2816 33 ( ( -LRB- cord-014516-r59usk02 2816 34 1 1 CD cord-014516-r59usk02 2816 35 of of IN cord-014516-r59usk02 2816 36 each each DT cord-014516-r59usk02 2816 37 ) ) -RRB- cord-014516-r59usk02 2816 38 . . . cord-014516-r59usk02 2817 1 6 6 CD cord-014516-r59usk02 2817 2 dogs dog NNS cord-014516-r59usk02 2817 3 had have VBD cord-014516-r59usk02 2817 4 stage stage NN cord-014516-r59usk02 2817 5 II ii CD cord-014516-r59usk02 2817 6 digit digit NN cord-014516-r59usk02 2817 7 melanoma melanoma NN cord-014516-r59usk02 2817 8 with with IN cord-014516-r59usk02 2817 9 an an DT cord-014516-r59usk02 2817 10 equal equal JJ cord-014516-r59usk02 2817 11 sex sex NN cord-014516-r59usk02 2817 12 distribution distribution NN cord-014516-r59usk02 2817 13 and and CC cord-014516-r59usk02 2817 14 a a DT cord-014516-r59usk02 2817 15 median median JJ cord-014516-r59usk02 2817 16 age age NN cord-014516-r59usk02 2817 17 of of IN cord-014516-r59usk02 2817 18 7.8 7.8 CD cord-014516-r59usk02 2817 19 years year NNS cord-014516-r59usk02 2817 20 ( ( -LRB- cord-014516-r59usk02 2817 21 range range VBP cord-014516-r59usk02 2817 22 3 3 CD cord-014516-r59usk02 2817 23 - - SYM cord-014516-r59usk02 2817 24 10 10 CD cord-014516-r59usk02 2817 25 ) ) -RRB- cord-014516-r59usk02 2817 26 . . . cord-014516-r59usk02 2818 1 Currently currently RB cord-014516-r59usk02 2818 2 5 5 CD cord-014516-r59usk02 2818 3 still still RB cord-014516-r59usk02 2818 4 alive alive JJ cord-014516-r59usk02 2818 5 and and CC cord-014516-r59usk02 2818 6 one one CD cord-014516-r59usk02 2818 7 dead dead JJ cord-014516-r59usk02 2818 8 , , , cord-014516-r59usk02 2818 9 the the DT cord-014516-r59usk02 2818 10 latter latter JJ cord-014516-r59usk02 2818 11 following follow VBG cord-014516-r59usk02 2818 12 surgery surgery NN cord-014516-r59usk02 2818 13 for for IN cord-014516-r59usk02 2818 14 resection resection NN cord-014516-r59usk02 2818 15 of of IN cord-014516-r59usk02 2818 16 a a DT cord-014516-r59usk02 2818 17 rib rib NN cord-014516-r59usk02 2818 18 osteosarcoma osteosarcoma NN cord-014516-r59usk02 2818 19 The the DT cord-014516-r59usk02 2818 20 median median JJ cord-014516-r59usk02 2818 21 survival survival NN cord-014516-r59usk02 2818 22 time time NN cord-014516-r59usk02 2818 23 of of IN cord-014516-r59usk02 2818 24 the the DT cord-014516-r59usk02 2818 25 dogs dog NNS cord-014516-r59usk02 2818 26 still still RB cord-014516-r59usk02 2818 27 alive alive JJ cord-014516-r59usk02 2818 28 is be VBZ cord-014516-r59usk02 2818 29 25.5 25.5 CD cord-014516-r59usk02 2818 30 months month NNS cord-014516-r59usk02 2819 1 ( ( -LRB- cord-014516-r59usk02 2819 2 range range NNP cord-014516-r59usk02 2819 3 5 5 CD cord-014516-r59usk02 2819 4 - - SYM cord-014516-r59usk02 2819 5 40 40 CD cord-014516-r59usk02 2819 6 ) ) -RRB- cord-014516-r59usk02 2819 7 versus versus IN cord-014516-r59usk02 2819 8 13.4 13.4 CD cord-014516-r59usk02 2819 9 months month NNS cord-014516-r59usk02 2819 10 ( ( -LRB- cord-014516-r59usk02 2819 11 range range VBP cord-014516-r59usk02 2819 12 2 2 CD cord-014516-r59usk02 2819 13 - - SYM cord-014516-r59usk02 2819 14 25 25 CD cord-014516-r59usk02 2819 15 ) ) -RRB- cord-014516-r59usk02 2819 16 for for IN cord-014516-r59usk02 2819 17 the the DT cord-014516-r59usk02 2819 18 dogs dog NNS cord-014516-r59usk02 2819 19 that that WDT cord-014516-r59usk02 2819 20 have have VBP cord-014516-r59usk02 2819 21 died die VBN cord-014516-r59usk02 2819 22 . . . cord-014516-r59usk02 2820 1 None none NN cord-014516-r59usk02 2820 2 of of IN cord-014516-r59usk02 2820 3 the the DT cord-014516-r59usk02 2820 4 dogs dog NNS cord-014516-r59usk02 2820 5 showed show VBD cord-014516-r59usk02 2820 6 any any DT cord-014516-r59usk02 2820 7 adverse adverse JJ cord-014516-r59usk02 2820 8 effect effect NN cord-014516-r59usk02 2820 9 to to IN cord-014516-r59usk02 2820 10 the the DT cord-014516-r59usk02 2820 11 vaccine vaccine NN cord-014516-r59usk02 2820 12 Infected infected JJ cord-014516-r59usk02 2820 13 macrophages macrophage NNS cord-014516-r59usk02 2820 14 can can MD cord-014516-r59usk02 2820 15 cause cause VB cord-014516-r59usk02 2820 16 injury injury NN cord-014516-r59usk02 2820 17 in in IN cord-014516-r59usk02 2820 18 different different JJ cord-014516-r59usk02 2820 19 organs organ NNS cord-014516-r59usk02 2820 20 , , , cord-014516-r59usk02 2820 21 including include VBG cord-014516-r59usk02 2820 22 the the DT cord-014516-r59usk02 2820 23 kidney kidney NN cord-014516-r59usk02 2820 24 . . . cord-014516-r59usk02 2821 1 CVL CVL NNP cord-014516-r59usk02 2821 2 is be VBZ cord-014516-r59usk02 2821 3 known know VBN cord-014516-r59usk02 2821 4 as as IN cord-014516-r59usk02 2821 5 a a DT cord-014516-r59usk02 2821 6 common common JJ cord-014516-r59usk02 2821 7 cause cause NN cord-014516-r59usk02 2821 8 of of IN cord-014516-r59usk02 2821 9 glomerulonephritis glomerulonephritis NN cord-014516-r59usk02 2821 10 . . . cord-014516-r59usk02 2822 1 Thus thus RB cord-014516-r59usk02 2822 2 , , , cord-014516-r59usk02 2822 3 this this DT cord-014516-r59usk02 2822 4 study study NN cord-014516-r59usk02 2822 5 aimed aim VBD cord-014516-r59usk02 2822 6 to to TO cord-014516-r59usk02 2822 7 investigate investigate VB cord-014516-r59usk02 2822 8 and and CC cord-014516-r59usk02 2822 9 characterize characterize VB cord-014516-r59usk02 2822 10 the the DT cord-014516-r59usk02 2822 11 renal renal JJ cord-014516-r59usk02 2822 12 lesions lesion NNS cord-014516-r59usk02 2822 13 in in IN cord-014516-r59usk02 2822 14 dogs dog NNS cord-014516-r59usk02 2822 15 seropositive seropositive JJ cord-014516-r59usk02 2822 16 for for IN cord-014516-r59usk02 2822 17 Leishmania Leishmania NNP cord-014516-r59usk02 2822 18 sp sp NNP cord-014516-r59usk02 2822 19 . . . cord-014516-r59usk02 2823 1 in in IN cord-014516-r59usk02 2823 2 Brazil Brazil NNP cord-014516-r59usk02 2823 3 . . . cord-014516-r59usk02 2824 1 This this DT cord-014516-r59usk02 2824 2 project project NN cord-014516-r59usk02 2824 3 was be VBD cord-014516-r59usk02 2824 4 approved approve VBN cord-014516-r59usk02 2824 5 by by IN cord-014516-r59usk02 2824 6 the the DT cord-014516-r59usk02 2824 7 animal animal NN cord-014516-r59usk02 2824 8 ethics ethic NNS cord-014516-r59usk02 2824 9 committee committee NN cord-014516-r59usk02 2824 10 of of IN cord-014516-r59usk02 2824 11 UECE UECE NNP cord-014516-r59usk02 2824 12 , , , cord-014516-r59usk02 2824 13 Brazil Brazil NNP cord-014516-r59usk02 2824 14 . . . cord-014516-r59usk02 2825 1 Twenty twenty CD cord-014516-r59usk02 2825 2 adult adult NN cord-014516-r59usk02 2825 3 dogs dog NNS cord-014516-r59usk02 2825 4 seropositive seropositive JJ cord-014516-r59usk02 2825 5 for for IN cord-014516-r59usk02 2825 6 CVL CVL NNP cord-014516-r59usk02 2825 7 from from IN cord-014516-r59usk02 2825 8 Center Center NNP cord-014516-r59usk02 2825 9 for for IN cord-014516-r59usk02 2825 10 Zoonosis Zoonosis NNP cord-014516-r59usk02 2825 11 Control Control NNP cord-014516-r59usk02 2825 12 were be VBD cord-014516-r59usk02 2825 13 randomly randomly RB cord-014516-r59usk02 2825 14 selected select VBN cord-014516-r59usk02 2825 15 for for IN cord-014516-r59usk02 2825 16 this this DT cord-014516-r59usk02 2825 17 experiment experiment NN cord-014516-r59usk02 2825 18 . . . cord-014516-r59usk02 2826 1 CVL CVL NNP cord-014516-r59usk02 2826 2 was be VBD cord-014516-r59usk02 2826 3 diagnosed diagnose VBN cord-014516-r59usk02 2826 4 by by IN cord-014516-r59usk02 2826 5 immunofluorescence immunofluorescence NN cord-014516-r59usk02 2826 6 and and CC cord-014516-r59usk02 2826 7 ELISA ELISA NNP cord-014516-r59usk02 2826 8 . . . cord-014516-r59usk02 2827 1 Urine urine NN cord-014516-r59usk02 2827 2 and and CC cord-014516-r59usk02 2827 3 blood blood NN cord-014516-r59usk02 2827 4 sampling sampling NN cord-014516-r59usk02 2827 5 and and CC cord-014516-r59usk02 2827 6 kidney kidney NN cord-014516-r59usk02 2827 7 harvesting harvesting NN cord-014516-r59usk02 2827 8 were be VBD cord-014516-r59usk02 2827 9 performed perform VBN cord-014516-r59usk02 2827 10 immediately immediately RB cord-014516-r59usk02 2827 11 after after IN cord-014516-r59usk02 2827 12 euthanasia euthanasia NN cord-014516-r59usk02 2827 13 that that IN cord-014516-r59usk02 2827 14 the the DT cord-014516-r59usk02 2827 15 glomerulonephritis glomerulonephritis NN cord-014516-r59usk02 2827 16 is be VBZ cord-014516-r59usk02 2827 17 a a DT cord-014516-r59usk02 2827 18 common common JJ cord-014516-r59usk02 2827 19 sequelae sequela NNS cord-014516-r59usk02 2827 20 related relate VBN cord-014516-r59usk02 2827 21 to to IN cord-014516-r59usk02 2827 22 leishmaniasis leishmaniasis NN cord-014516-r59usk02 2827 23 infection infection NN cord-014516-r59usk02 2827 24 . . . cord-014516-r59usk02 2828 1 Even even RB cord-014516-r59usk02 2828 2 dogs dog NNS cord-014516-r59usk02 2828 3 in in IN cord-014516-r59usk02 2828 4 stage stage NN cord-014516-r59usk02 2828 5 1 1 CD cord-014516-r59usk02 2828 6 of of IN cord-014516-r59usk02 2828 7 CKD CKD NNP cord-014516-r59usk02 2828 8 showed show VBD cord-014516-r59usk02 2828 9 significant significant JJ cord-014516-r59usk02 2828 10 renal renal JJ cord-014516-r59usk02 2828 11 histopathological histopathological JJ cord-014516-r59usk02 2828 12 changes change NNS cord-014516-r59usk02 2828 13 . . . cord-014516-r59usk02 2829 1 Animals animal NNS cord-014516-r59usk02 2829 2 infected infect VBN cord-014516-r59usk02 2829 3 with with IN cord-014516-r59usk02 2829 4 Leishmania Leishmania NNP cord-014516-r59usk02 2829 5 sp sp NN cord-014516-r59usk02 2829 6 . . . cord-014516-r59usk02 2829 7 may may MD cord-014516-r59usk02 2829 8 have have VB cord-014516-r59usk02 2829 9 severe severe JJ cord-014516-r59usk02 2829 10 renal renal JJ cord-014516-r59usk02 2829 11 damage damage NN cord-014516-r59usk02 2829 12 and and CC cord-014516-r59usk02 2829 13 risk risk NN cord-014516-r59usk02 2829 14 of of IN cord-014516-r59usk02 2829 15 progressive progressive JJ cord-014516-r59usk02 2829 16 chronic chronic JJ cord-014516-r59usk02 2829 17 kidney kidney NN cord-014516-r59usk02 2829 18 disease disease NN cord-014516-r59usk02 2829 19 even even RB cord-014516-r59usk02 2829 20 when when WRB cord-014516-r59usk02 2829 21 no no DT cord-014516-r59usk02 2829 22 increase increase NN cord-014516-r59usk02 2829 23 of of IN cord-014516-r59usk02 2829 24 creatinine creatinine NN cord-014516-r59usk02 2829 25 levels level NNS cord-014516-r59usk02 2829 26 or or CC cord-014516-r59usk02 2829 27 proteinuria proteinuria NN cord-014516-r59usk02 2829 28 is be VBZ cord-014516-r59usk02 2829 29 detected detect VBN cord-014516-r59usk02 2829 30 . . . cord-014516-r59usk02 2830 1 Conflicts conflict NNS cord-014516-r59usk02 2830 2 of of IN cord-014516-r59usk02 2830 3 interest interest NN cord-014516-r59usk02 2830 4 : : : cord-014516-r59usk02 2830 5 The the DT cord-014516-r59usk02 2830 6 authors author NNS cord-014516-r59usk02 2830 7 received receive VBD cord-014516-r59usk02 2830 8 funding funding NN cord-014516-r59usk02 2830 9 to to TO cord-014516-r59usk02 2830 10 pay pay VB cord-014516-r59usk02 2830 11 the the DT cord-014516-r59usk02 2830 12 PhD phd NN cord-014516-r59usk02 2830 13 scholarship scholarship NN cord-014516-r59usk02 2830 14 of of IN cord-014516-r59usk02 2830 15 one one CD cord-014516-r59usk02 2830 16 student student NN cord-014516-r59usk02 2830 17 ( ( -LRB- cord-014516-r59usk02 2830 18 Conselho Conselho NNP cord-014516-r59usk02 2830 19 Nacional Nacional NNP cord-014516-r59usk02 2830 20 de de NNP cord-014516-r59usk02 2830 21 Pesquisa Pesquisa NNP cord-014516-r59usk02 2830 22 e e NNP cord-014516-r59usk02 2830 23 Desenvolvimento Desenvolvimento NNP cord-014516-r59usk02 2830 24 -CNPq -CNPq NNP cord-014516-r59usk02 2830 25 - - : cord-014516-r59usk02 2830 26 Brazil Brazil NNP cord-014516-r59usk02 2830 27 ) ) -RRB- cord-014516-r59usk02 2830 28 and and CC cord-014516-r59usk02 2830 29 received receive VBD cord-014516-r59usk02 2830 30 a a DT cord-014516-r59usk02 2830 31 research research NN cord-014516-r59usk02 2830 32 grant grant NN cord-014516-r59usk02 2830 33 from from IN cord-014516-r59usk02 2830 34 Fundac Fundac NNP cord-014516-r59usk02 2830 35 ßão ßão NNP cord-014516-r59usk02 2831 1 Cearense Cearense NNP cord-014516-r59usk02 2831 2 de de NNP cord-014516-r59usk02 2831 3 Apoio Apoio NNP cord-014516-r59usk02 2831 4 ao ao NNP cord-014516-r59usk02 2831 5 Desenvolvimento Desenvolvimento NNP cord-014516-r59usk02 2831 6 Cient Cient NNP cord-014516-r59usk02 2831 7 ıfico ıfico NN cord-014516-r59usk02 2832 1 e e LS cord-014516-r59usk02 2832 2 Tecnol Tecnol NNP cord-014516-r59usk02 2832 3 ogico ogico XX cord-014516-r59usk02 2833 1 -FUNCAP -FUNCAP NNP cord-014516-r59usk02 2833 2 . . . cord-014516-r59usk02 2834 1 Anaplasma Anaplasma NNP cord-014516-r59usk02 2834 2 phagocytophilum phagocytophilum NN cord-014516-r59usk02 2834 3 , , , cord-014516-r59usk02 2834 4 the the DT cord-014516-r59usk02 2834 5 causative causative JJ cord-014516-r59usk02 2834 6 agent agent NN cord-014516-r59usk02 2834 7 of of IN cord-014516-r59usk02 2834 8 canine canine NNP cord-014516-r59usk02 2834 9 granulocytic granulocytic NNP cord-014516-r59usk02 2834 10 anaplasmosis anaplasmosis NN cord-014516-r59usk02 2834 11 , , , cord-014516-r59usk02 2834 12 is be VBZ cord-014516-r59usk02 2834 13 an an DT cord-014516-r59usk02 2834 14 obligatory obligatory JJ cord-014516-r59usk02 2834 15 intracellular intracellular JJ cord-014516-r59usk02 2834 16 bacterium bacterium NN cord-014516-r59usk02 2834 17 transmitted transmit VBN cord-014516-r59usk02 2834 18 by by IN cord-014516-r59usk02 2834 19 Ixodes Ixodes NNP cord-014516-r59usk02 2834 20 ticks tick NNS cord-014516-r59usk02 2834 21 . . . cord-014516-r59usk02 2835 1 Transmission transmission NN cord-014516-r59usk02 2835 2 via via IN cord-014516-r59usk02 2835 3 blood blood NN cord-014516-r59usk02 2835 4 transfusion transfusion NN cord-014516-r59usk02 2835 5 has have VBZ cord-014516-r59usk02 2835 6 rarely rarely RB cord-014516-r59usk02 2835 7 been be VBN cord-014516-r59usk02 2835 8 described describe VBN cord-014516-r59usk02 2835 9 in in IN cord-014516-r59usk02 2835 10 human human JJ cord-014516-r59usk02 2835 11 medicine medicine NN cord-014516-r59usk02 2835 12 and and CC cord-014516-r59usk02 2835 13 once once RB cord-014516-r59usk02 2835 14 in in IN cord-014516-r59usk02 2835 15 a a DT cord-014516-r59usk02 2835 16 dog dog NN cord-014516-r59usk02 2835 17 . . . cord-014516-r59usk02 2836 1 In in IN cord-014516-r59usk02 2836 2 the the DT cord-014516-r59usk02 2836 3 Berlin Berlin NNP cord-014516-r59usk02 2836 4 / / SYM cord-014516-r59usk02 2836 5 Brandenburg Brandenburg NNP cord-014516-r59usk02 2836 6 area area NN cord-014516-r59usk02 2836 7 the the DT cord-014516-r59usk02 2836 8 seroprevalence seroprevalence NN cord-014516-r59usk02 2836 9 rate rate NN cord-014516-r59usk02 2836 10 in in IN cord-014516-r59usk02 2836 11 dogs dog NNS cord-014516-r59usk02 2836 12 was be VBD cord-014516-r59usk02 2836 13 43 43 CD cord-014516-r59usk02 2836 14 % % NN cord-014516-r59usk02 2836 15 regardless regardless RB cord-014516-r59usk02 2836 16 of of IN cord-014516-r59usk02 2836 17 health health NN cord-014516-r59usk02 2836 18 status status NN cord-014516-r59usk02 2836 19 . . . cord-014516-r59usk02 2837 1 The the DT cord-014516-r59usk02 2837 2 aim aim NN cord-014516-r59usk02 2837 3 of of IN cord-014516-r59usk02 2837 4 this this DT cord-014516-r59usk02 2837 5 study study NN cord-014516-r59usk02 2837 6 was be VBD cord-014516-r59usk02 2837 7 to to TO cord-014516-r59usk02 2837 8 evaluate evaluate VB cord-014516-r59usk02 2837 9 PCR PCR NNP cord-014516-r59usk02 2837 10 screening screening NN cord-014516-r59usk02 2837 11 results result NNS cord-014516-r59usk02 2837 12 for for IN cord-014516-r59usk02 2837 13 A. a. NN cord-014516-r59usk02 2837 14 phagocytophilum phagocytophilum NN cord-014516-r59usk02 2837 15 in in IN cord-014516-r59usk02 2837 16 canine canine JJ cord-014516-r59usk02 2837 17 blood blood NN cord-014516-r59usk02 2837 18 donors donor NNS cord-014516-r59usk02 2837 19 between between IN cord-014516-r59usk02 2837 20 2006 2006 CD cord-014516-r59usk02 2837 21 -2012 -2012 NN cord-014516-r59usk02 2837 22 in in IN cord-014516-r59usk02 2837 23 order order NN cord-014516-r59usk02 2837 24 to to TO cord-014516-r59usk02 2837 25 estimate estimate VB cord-014516-r59usk02 2837 26 the the DT cord-014516-r59usk02 2837 27 risk risk NN cord-014516-r59usk02 2837 28 of of IN cord-014516-r59usk02 2837 29 transfusion transfusion NN cord-014516-r59usk02 2837 30 - - HYPH cord-014516-r59usk02 2837 31 transmitted transmit VBN cord-014516-r59usk02 2837 32 infection.917 infection.917 NNP cord-014516-r59usk02 2837 33 EDTA edta NN cord-014516-r59usk02 2837 34 blood blood NN cord-014516-r59usk02 2837 35 samples sample NNS cord-014516-r59usk02 2837 36 from from IN cord-014516-r59usk02 2837 37 517 517 CD cord-014516-r59usk02 2837 38 dogs dog NNS cord-014516-r59usk02 2837 39 were be VBD cord-014516-r59usk02 2837 40 submitted submit VBN cord-014516-r59usk02 2837 41 for for IN cord-014516-r59usk02 2837 42 A. a. NN cord-014516-r59usk02 2837 43 phagocytophilum phagocytophilum JJ cord-014516-r59usk02 2837 44 real real JJ cord-014516-r59usk02 2837 45 - - HYPH cord-014516-r59usk02 2837 46 time time NN cord-014516-r59usk02 2837 47 PCR PCR NNP cord-014516-r59usk02 2837 48 testing testing NN cord-014516-r59usk02 2837 49 ( ( -LRB- cord-014516-r59usk02 2837 50 targeting target VBG cord-014516-r59usk02 2837 51 the the DT cord-014516-r59usk02 2837 52 msp2gene msp2gene NNP cord-014516-r59usk02 2837 53 ) ) -RRB- cord-014516-r59usk02 2837 54 . . . cord-014516-r59usk02 2838 1 Altogether altogether RB cord-014516-r59usk02 2838 2 158 158 CD cord-014516-r59usk02 2838 3 dogs dog NNS cord-014516-r59usk02 2838 4 were be VBD cord-014516-r59usk02 2838 5 tested test VBN cord-014516-r59usk02 2838 6 up up IN cord-014516-r59usk02 2838 7 to to TO cord-014516-r59usk02 2838 8 11 11 CD cord-014516-r59usk02 2838 9 times time NNS cord-014516-r59usk02 2838 10 . . . cord-014516-r59usk02 2839 1 Clinical clinical JJ cord-014516-r59usk02 2839 2 and and CC cord-014516-r59usk02 2839 3 laboratory laboratory NN cord-014516-r59usk02 2839 4 data datum NNS cord-014516-r59usk02 2839 5 were be VBD cord-014516-r59usk02 2839 6 examined examine VBN cord-014516-r59usk02 2839 7 before before IN cord-014516-r59usk02 2839 8 each each DT cord-014516-r59usk02 2839 9 donation donation NN cord-014516-r59usk02 2839 10 . . . cord-014516-r59usk02 2840 1 Statistical statistical JJ cord-014516-r59usk02 2840 2 analysis analysis NN cord-014516-r59usk02 2840 3 was be VBD cord-014516-r59usk02 2840 4 performed perform VBN cord-014516-r59usk02 2840 5 using use VBG cord-014516-r59usk02 2840 6 SPSS SPSS NNP cord-014516-r59usk02 2840 7 17.0.The 17.0.the CD cord-014516-r59usk02 2840 8 PCR PCR NNP cord-014516-r59usk02 2840 9 test test NN cord-014516-r59usk02 2840 10 was be VBD cord-014516-r59usk02 2840 11 positive positive JJ cord-014516-r59usk02 2840 12 for for IN cord-014516-r59usk02 2840 13 21 21 CD cord-014516-r59usk02 2840 14 of of IN cord-014516-r59usk02 2840 15 the the DT cord-014516-r59usk02 2840 16 917 917 CD cord-014516-r59usk02 2840 17 samples sample NNS cord-014516-r59usk02 2840 18 . . . cord-014516-r59usk02 2841 1 None none NN cord-014516-r59usk02 2841 2 of of IN cord-014516-r59usk02 2841 3 the the DT cord-014516-r59usk02 2841 4 dogs dog NNS cord-014516-r59usk02 2841 5 tested test VBD cord-014516-r59usk02 2841 6 PCR PCR NNP cord-014516-r59usk02 2841 7 positive positive JJ cord-014516-r59usk02 2841 8 more more RBR cord-014516-r59usk02 2841 9 than than IN cord-014516-r59usk02 2841 10 once once RB cord-014516-r59usk02 2841 11 . . . cord-014516-r59usk02 2842 1 Positive positive JJ cord-014516-r59usk02 2842 2 results result NNS cord-014516-r59usk02 2842 3 were be VBD cord-014516-r59usk02 2842 4 most most RBS cord-014516-r59usk02 2842 5 often often RB cord-014516-r59usk02 2842 6 detected detect VBN cord-014516-r59usk02 2842 7 in in IN cord-014516-r59usk02 2842 8 June June NNP cord-014516-r59usk02 2842 9 ( ( -LRB- cord-014516-r59usk02 2842 10 8) 8) NN cord-014516-r59usk02 2842 11 , , , cord-014516-r59usk02 2842 12 May May NNP cord-014516-r59usk02 2842 13 ( ( -LRB- cord-014516-r59usk02 2842 14 5 5 CD cord-014516-r59usk02 2842 15 ) ) -RRB- cord-014516-r59usk02 2842 16 , , , cord-014516-r59usk02 2842 17 and and CC cord-014516-r59usk02 2842 18 July July NNP cord-014516-r59usk02 2842 19 ( ( -LRB- cord-014516-r59usk02 2842 20 3 3 CD cord-014516-r59usk02 2842 21 ) ) -RRB- cord-014516-r59usk02 2842 22 , , , cord-014516-r59usk02 2842 23 but but CC cord-014516-r59usk02 2842 24 also also RB cord-014516-r59usk02 2842 25 in in IN cord-014516-r59usk02 2842 26 five five CD cord-014516-r59usk02 2842 27 other other JJ cord-014516-r59usk02 2842 28 months month NNS cord-014516-r59usk02 2842 29 . . . cord-014516-r59usk02 2843 1 In in IN cord-014516-r59usk02 2843 2 three three CD cord-014516-r59usk02 2843 3 dogs dog NNS cord-014516-r59usk02 2843 4 a a DT cord-014516-r59usk02 2843 5 mild mild JJ cord-014516-r59usk02 2843 6 increased increase VBN cord-014516-r59usk02 2843 7 in in IN cord-014516-r59usk02 2843 8 rectal rectal JJ cord-014516-r59usk02 2843 9 temperature temperature NN cord-014516-r59usk02 2843 10 ( ( -LRB- cord-014516-r59usk02 2843 11 ≥ ≥ CD cord-014516-r59usk02 2843 12 39,0 39,0 NNP cord-014516-r59usk02 2843 13 ° ° NN cord-014516-r59usk02 2843 14 C C NNP cord-014516-r59usk02 2843 15 ) ) -RRB- cord-014516-r59usk02 2843 16 was be VBD cord-014516-r59usk02 2843 17 documented document VBN cord-014516-r59usk02 2843 18 . . . cord-014516-r59usk02 2844 1 Mild mild JJ cord-014516-r59usk02 2844 2 laboratory laboratory NN cord-014516-r59usk02 2844 3 abnormalities abnormality NNS cord-014516-r59usk02 2844 4 were be VBD cord-014516-r59usk02 2844 5 noted note VBN cord-014516-r59usk02 2844 6 in in IN cord-014516-r59usk02 2844 7 11 11 CD cord-014516-r59usk02 2844 8 dogs dog NNS cord-014516-r59usk02 2844 9 : : : cord-014516-r59usk02 2844 10 thrombocytopenia thrombocytopenia NN cord-014516-r59usk02 2844 11 ( ( -LRB- cord-014516-r59usk02 2844 12 3 3 CD cord-014516-r59usk02 2844 13 ) ) -RRB- cord-014516-r59usk02 2844 14 , , . cord-014516-r59usk02 2845 1 leukocytosis leukocytosis NNP cord-014516-r59usk02 2845 2 ( ( -LRB- cord-014516-r59usk02 2845 3 2 2 CD cord-014516-r59usk02 2845 4 ) ) -RRB- cord-014516-r59usk02 2845 5 , , , cord-014516-r59usk02 2845 6 leukopenia leukopenia FW cord-014516-r59usk02 2845 7 ( ( -LRB- cord-014516-r59usk02 2845 8 2 2 CD cord-014516-r59usk02 2845 9 ) ) -RRB- cord-014516-r59usk02 2845 10 , , , cord-014516-r59usk02 2845 11 anemia anemia NN cord-014516-r59usk02 2845 12 ( ( -LRB- cord-014516-r59usk02 2845 13 1 1 CD cord-014516-r59usk02 2845 14 ) ) -RRB- cord-014516-r59usk02 2845 15 and and CC cord-014516-r59usk02 2845 16 hyperproteinemia hyperproteinemia NNP cord-014516-r59usk02 2845 17 ( ( -LRB- cord-014516-r59usk02 2845 18 6/18 6/18 CD cord-014516-r59usk02 2845 19 ) ) -RRB- cord-014516-r59usk02 2845 20 ; ; . cord-014516-r59usk02 2846 1 four four CD cord-014516-r59usk02 2846 2 dogs dog NNS cord-014516-r59usk02 2846 3 had have VBD cord-014516-r59usk02 2846 4 more more JJR cord-014516-r59usk02 2846 5 than than IN cord-014516-r59usk02 2846 6 one one CD cord-014516-r59usk02 2846 7 abnormality abnormality NN cord-014516-r59usk02 2846 8 . . . cord-014516-r59usk02 2847 1 There there EX cord-014516-r59usk02 2847 2 was be VBD cord-014516-r59usk02 2847 3 no no DT cord-014516-r59usk02 2847 4 significant significant JJ cord-014516-r59usk02 2847 5 difference difference NN cord-014516-r59usk02 2847 6 between between IN cord-014516-r59usk02 2847 7 the the DT cord-014516-r59usk02 2847 8 PCR PCR NNP cord-014516-r59usk02 2847 9 negative negative JJ cord-014516-r59usk02 2847 10 and and CC cord-014516-r59usk02 2847 11 positive positive JJ cord-014516-r59usk02 2847 12 blood blood NN cord-014516-r59usk02 2847 13 samples sample NNS cord-014516-r59usk02 2847 14 in in IN cord-014516-r59usk02 2847 15 regard regard NN cord-014516-r59usk02 2847 16 to to IN cord-014516-r59usk02 2847 17 laboratory laboratory NN cord-014516-r59usk02 2847 18 abnormalities abnormality NNS cord-014516-r59usk02 2847 19 . . . cord-014516-r59usk02 2848 1 Altogether altogether RB cord-014516-r59usk02 2848 2 , , , cord-014516-r59usk02 2848 3 2.3 2.3 CD cord-014516-r59usk02 2848 4 % % NN cord-014516-r59usk02 2848 5 of of IN cord-014516-r59usk02 2848 6 blood blood NN cord-014516-r59usk02 2848 7 samples sample NNS cord-014516-r59usk02 2848 8 from from IN cord-014516-r59usk02 2848 9 healthy healthy JJ cord-014516-r59usk02 2848 10 canine canine JJ cord-014516-r59usk02 2848 11 blood blood NN cord-014516-r59usk02 2848 12 donors donor NNS cord-014516-r59usk02 2848 13 were be VBD cord-014516-r59usk02 2848 14 PCR PCR NNP cord-014516-r59usk02 2848 15 positive positive JJ cord-014516-r59usk02 2848 16 for for IN cord-014516-r59usk02 2848 17 A. a. NN cord-014516-r59usk02 2848 18 phagocytophilum phagocytophilum NN cord-014516-r59usk02 2848 19 . . . cord-014516-r59usk02 2849 1 Therefore therefore RB cord-014516-r59usk02 2849 2 , , , cord-014516-r59usk02 2849 3 blood blood NN cord-014516-r59usk02 2849 4 donors donor NNS cord-014516-r59usk02 2849 5 should should MD cord-014516-r59usk02 2849 6 be be VB cord-014516-r59usk02 2849 7 screened screen VBN cord-014516-r59usk02 2849 8 by by IN cord-014516-r59usk02 2849 9 PCR PCR NNP cord-014516-r59usk02 2849 10 in in IN cord-014516-r59usk02 2849 11 endemic endemic JJ cord-014516-r59usk02 2849 12 areas area NNS cord-014516-r59usk02 2849 13 all all DT cord-014516-r59usk02 2849 14 year year NN cord-014516-r59usk02 2849 15 round round RB cord-014516-r59usk02 2849 16 . . . cord-014516-r59usk02 2850 1 No no DT cord-014516-r59usk02 2850 2 conflicts conflict NNS cord-014516-r59usk02 2850 3 of of IN cord-014516-r59usk02 2850 4 interest interest NN cord-014516-r59usk02 2850 5 reported report VBN cord-014516-r59usk02 2850 6 . . . cord-014516-r59usk02 2851 1 The the DT cord-014516-r59usk02 2851 2 study study NN cord-014516-r59usk02 2851 3 population population NN cord-014516-r59usk02 2851 4 consisted consist VBD cord-014516-r59usk02 2851 5 of of IN cord-014516-r59usk02 2851 6 358 358 CD cord-014516-r59usk02 2851 7 cats cat NNS cord-014516-r59usk02 2851 8 , , , cord-014516-r59usk02 2851 9 including include VBG cord-014516-r59usk02 2851 10 98 98 CD cord-014516-r59usk02 2851 11 control control NN cord-014516-r59usk02 2851 12 cats cat NNS cord-014516-r59usk02 2851 13 recruited recruit VBN cord-014516-r59usk02 2851 14 from from IN cord-014516-r59usk02 2851 15 29 29 CD cord-014516-r59usk02 2851 16 veterinary veterinary JJ cord-014516-r59usk02 2851 17 practices practice NNS cord-014516-r59usk02 2851 18 across across IN cord-014516-r59usk02 2851 19 the the DT cord-014516-r59usk02 2851 20 country country NN cord-014516-r59usk02 2851 21 . . . cord-014516-r59usk02 2852 1 Among among IN cord-014516-r59usk02 2852 2 the the DT cord-014516-r59usk02 2852 3 260 260 CD cord-014516-r59usk02 2852 4 disease disease NN cord-014516-r59usk02 2852 5 cats cat NNS cord-014516-r59usk02 2852 6 , , , cord-014516-r59usk02 2852 7 127 127 CD cord-014516-r59usk02 2852 8 cats cat NNS cord-014516-r59usk02 2852 9 presented present VBD cord-014516-r59usk02 2852 10 URTD URTD NNP cord-014516-r59usk02 2852 11 , , , cord-014516-r59usk02 2852 12 149 149 CD cord-014516-r59usk02 2852 13 cats cat NNS cord-014516-r59usk02 2852 14 had have VBD cord-014516-r59usk02 2852 15 conjunctivitis conjunctivitis NN cord-014516-r59usk02 2852 16 and and CC cord-014516-r59usk02 2852 17 153 153 CD cord-014516-r59usk02 2852 18 cats cat NNS cord-014516-r59usk02 2852 19 suffered suffer VBD cord-014516-r59usk02 2852 20 chronic chronic JJ cord-014516-r59usk02 2852 21 gingivostomatitis gingivostomatitis NN cord-014516-r59usk02 2852 22 , , , cord-014516-r59usk02 2852 23 many many JJ cord-014516-r59usk02 2852 24 of of IN cord-014516-r59usk02 2852 25 them -PRON- PRP cord-014516-r59usk02 2852 26 presenting present VBG cord-014516-r59usk02 2852 27 more more JJR cord-014516-r59usk02 2852 28 than than IN cord-014516-r59usk02 2852 29 one one CD cord-014516-r59usk02 2852 30 clinical clinical JJ cord-014516-r59usk02 2852 31 sign sign NN cord-014516-r59usk02 2852 32 . . . cord-014516-r59usk02 2853 1 PCR PCR NNP cord-014516-r59usk02 2853 2 for for IN cord-014516-r59usk02 2853 3 the the DT cord-014516-r59usk02 2853 4 above above RB cord-014516-r59usk02 2853 5 - - HYPH cord-014516-r59usk02 2853 6 mentioned mention VBN cord-014516-r59usk02 2853 7 pathogens pathogen NNS cord-014516-r59usk02 2853 8 was be VBD cord-014516-r59usk02 2853 9 performed perform VBN cord-014516-r59usk02 2853 10 from from IN cord-014516-r59usk02 2853 11 pooled pool VBN cord-014516-r59usk02 2853 12 conjunctival conjunctival NN cord-014516-r59usk02 2853 13 and and CC cord-014516-r59usk02 2853 14 oropharyngeal oropharyngeal JJ cord-014516-r59usk02 2853 15 swabs swab NNS cord-014516-r59usk02 2853 16 for for IN cord-014516-r59usk02 2853 17 each each DT cord-014516-r59usk02 2853 18 cat cat NN cord-014516-r59usk02 2853 19 . . . cord-014516-r59usk02 2854 1 A a DT cord-014516-r59usk02 2854 2 questionnaire questionnaire NN cord-014516-r59usk02 2854 3 regarding regard VBG cord-014516-r59usk02 2854 4 signalment signalment JJ cord-014516-r59usk02 2854 5 ( ( -LRB- cord-014516-r59usk02 2854 6 age age NN cord-014516-r59usk02 2854 7 , , , cord-014516-r59usk02 2854 8 breed breed NN cord-014516-r59usk02 2854 9 , , , cord-014516-r59usk02 2854 10 sex sex NN cord-014516-r59usk02 2854 11 , , , cord-014516-r59usk02 2854 12 neuter neuter JJ cord-014516-r59usk02 2854 13 status status NN cord-014516-r59usk02 2854 14 ) ) -RRB- cord-014516-r59usk02 2854 15 , , , cord-014516-r59usk02 2854 16 environment environment NN cord-014516-r59usk02 2854 17 ( ( -LRB- cord-014516-r59usk02 2854 18 indoor indoor JJ cord-014516-r59usk02 2854 19 , , , cord-014516-r59usk02 2854 20 number number NN cord-014516-r59usk02 2854 21 of of IN cord-014516-r59usk02 2854 22 cats cat NNS cord-014516-r59usk02 2854 23 in in IN cord-014516-r59usk02 2854 24 household household NN cord-014516-r59usk02 2854 25 ) ) -RRB- cord-014516-r59usk02 2854 26 and and CC cord-014516-r59usk02 2854 27 vaccination vaccination NN cord-014516-r59usk02 2854 28 history history NN cord-014516-r59usk02 2854 29 was be VBD cord-014516-r59usk02 2854 30 obtained obtain VBN cord-014516-r59usk02 2854 31 . . . cord-014516-r59usk02 2855 1 Data datum NNS cord-014516-r59usk02 2855 2 was be VBD cord-014516-r59usk02 2855 3 analysed analyse VBN cord-014516-r59usk02 2855 4 by by IN cord-014516-r59usk02 2855 5 multivariable multivariable JJ cord-014516-r59usk02 2855 6 logistic logistic JJ cord-014516-r59usk02 2855 7 regression regression NN cord-014516-r59usk02 2855 8 with with IN cord-014516-r59usk02 2855 9 alpha alpha NN cord-014516-r59usk02 2855 10 equal equal JJ cord-014516-r59usk02 2855 11 to to IN cord-014516-r59usk02 2855 12 < < XX cord-014516-r59usk02 2855 13 0.05.The 0.05.the CD cord-014516-r59usk02 2855 14 prevalence prevalence NN cord-014516-r59usk02 2855 15 for for IN cord-014516-r59usk02 2855 16 the the DT cord-014516-r59usk02 2855 17 four four CD cord-014516-r59usk02 2855 18 pathogens pathogen NNS cord-014516-r59usk02 2855 19 has have VBZ cord-014516-r59usk02 2855 20 been be VBN cord-014516-r59usk02 2855 21 previously previously RB cord-014516-r59usk02 2855 22 reported report VBN cord-014516-r59usk02 2855 23 in in IN cord-014516-r59usk02 2855 24 detail detail NN cord-014516-r59usk02 2855 25 . . . cord-014516-r59usk02 2856 1 Briefly briefly RB cord-014516-r59usk02 2856 2 , , , cord-014516-r59usk02 2856 3 the the DT cord-014516-r59usk02 2856 4 prevalence prevalence NN cord-014516-r59usk02 2856 5 among among IN cord-014516-r59usk02 2856 6 the the DT cord-014516-r59usk02 2856 7 four four CD cord-014516-r59usk02 2856 8 groups group NNS cord-014516-r59usk02 2856 9 ( ( -LRB- cord-014516-r59usk02 2856 10 including include VBG cord-014516-r59usk02 2856 11 controls control NNS cord-014516-r59usk02 2856 12 ) ) -RRB- cord-014516-r59usk02 2856 13 ranged range VBD cord-014516-r59usk02 2856 14 from from IN cord-014516-r59usk02 2856 15 6 6 CD cord-014516-r59usk02 2856 16 to to TO cord-014516-r59usk02 2856 17 28 28 CD cord-014516-r59usk02 2856 18 % % NN cord-014516-r59usk02 2856 19 for for IN cord-014516-r59usk02 2856 20 FHV-1 FHV-1 NNP cord-014516-r59usk02 2856 21 , , , cord-014516-r59usk02 2856 22 15 15 CD cord-014516-r59usk02 2856 23 - - SYM cord-014516-r59usk02 2856 24 58 58 CD cord-014516-r59usk02 2856 25 % % NN cord-014516-r59usk02 2856 26 for for IN cord-014516-r59usk02 2856 27 FCV FCV NNP cord-014516-r59usk02 2856 28 , , , cord-014516-r59usk02 2856 29 2 2 CD cord-014516-r59usk02 2856 30 - - SYM cord-014516-r59usk02 2856 31 20 20 CD cord-014516-r59usk02 2856 32 % % NN cord-014516-r59usk02 2856 33 for for IN cord-014516-r59usk02 2856 34 Chlamydophila Chlamydophila NNP cord-014516-r59usk02 2856 35 felis felis NN cord-014516-r59usk02 2856 36 and and CC cord-014516-r59usk02 2856 37 20 20 CD cord-014516-r59usk02 2856 38 - - SYM cord-014516-r59usk02 2856 39 46 46 CD cord-014516-r59usk02 2856 40 % % NN cord-014516-r59usk02 2856 41 for for IN cord-014516-r59usk02 2856 42 Mycoplasma Mycoplasma NNP cord-014516-r59usk02 2856 43 felis felis NNP cord-014516-r59usk02 2856 44 . . . cord-014516-r59usk02 2857 1 In in IN cord-014516-r59usk02 2857 2 the the DT cord-014516-r59usk02 2857 3 univariate univariate JJ cord-014516-r59usk02 2857 4 analysis analysis NN cord-014516-r59usk02 2857 5 , , , cord-014516-r59usk02 2857 6 age age NN cord-014516-r59usk02 2857 7 , , , cord-014516-r59usk02 2857 8 neutering neuter VBG cord-014516-r59usk02 2857 9 status status NN cord-014516-r59usk02 2857 10 , , , cord-014516-r59usk02 2857 11 being be VBG cord-014516-r59usk02 2857 12 purebred purebred JJ cord-014516-r59usk02 2857 13 , , , cord-014516-r59usk02 2857 14 indoor indoor JJ cord-014516-r59usk02 2857 15 keeping keeping NN cord-014516-r59usk02 2857 16 , , , cord-014516-r59usk02 2857 17 number number NN cord-014516-r59usk02 2857 18 of of IN cord-014516-r59usk02 2857 19 cats cat NNS cord-014516-r59usk02 2857 20 in in IN cord-014516-r59usk02 2857 21 the the DT cord-014516-r59usk02 2857 22 household household NN cord-014516-r59usk02 2857 23 and and CC cord-014516-r59usk02 2857 24 body body NN cord-014516-r59usk02 2857 25 weight weight NN cord-014516-r59usk02 2857 26 were be VBD cord-014516-r59usk02 2857 27 variably variably RB cord-014516-r59usk02 2857 28 associated associate VBN cord-014516-r59usk02 2857 29 with with IN cord-014516-r59usk02 2857 30 the the DT cord-014516-r59usk02 2857 31 different different JJ cord-014516-r59usk02 2857 32 groups group NNS cord-014516-r59usk02 2857 33 of of IN cord-014516-r59usk02 2857 34 disease disease NN cord-014516-r59usk02 2857 35 and and CC cord-014516-r59usk02 2857 36 the the DT cord-014516-r59usk02 2857 37 presence presence NN cord-014516-r59usk02 2857 38 of of IN cord-014516-r59usk02 2857 39 the the DT cord-014516-r59usk02 2857 40 pathogens pathogen NNS cord-014516-r59usk02 2857 41 . . . cord-014516-r59usk02 2858 1 In in IN cord-014516-r59usk02 2858 2 the the DT cord-014516-r59usk02 2858 3 multivariable multivariable JJ cord-014516-r59usk02 2858 4 analysis analysis NN cord-014516-r59usk02 2858 5 , , , cord-014516-r59usk02 2858 6 only only RB cord-014516-r59usk02 2858 7 the the DT cord-014516-r59usk02 2858 8 following following JJ cord-014516-r59usk02 2858 9 factors factor NNS cord-014516-r59usk02 2858 10 remained remain VBD cord-014516-r59usk02 2858 11 significant significant JJ cord-014516-r59usk02 2858 12 . . . cord-014516-r59usk02 2859 1 In in IN cord-014516-r59usk02 2859 2 the the DT cord-014516-r59usk02 2859 3 multivariable multivariable JJ cord-014516-r59usk02 2859 4 analysis analysis NN cord-014516-r59usk02 2859 5 , , , cord-014516-r59usk02 2859 6 only only RB cord-014516-r59usk02 2859 7 the the DT cord-014516-r59usk02 2859 8 following following JJ cord-014516-r59usk02 2859 9 factors factor NNS cord-014516-r59usk02 2859 10 remained remain VBD cord-014516-r59usk02 2859 11 significant significant JJ cord-014516-r59usk02 2859 12 : : : cord-014516-r59usk02 2859 13 URTD URTD NNP cord-014516-r59usk02 2859 14 was be VBD cord-014516-r59usk02 2859 15 significantly significantly RB cord-014516-r59usk02 2859 16 associated associate VBN cord-014516-r59usk02 2859 17 with with IN cord-014516-r59usk02 2859 18 positive positive JJ cord-014516-r59usk02 2859 19 results result NNS cord-014516-r59usk02 2859 20 for for IN cord-014516-r59usk02 2859 21 FHV-1 FHV-1 NNP cord-014516-r59usk02 2859 22 , , , cord-014516-r59usk02 2859 23 Chlamydophila Chlamydophila NNP cord-014516-r59usk02 2859 24 felis felis NN cord-014516-r59usk02 2859 25 and and CC cord-014516-r59usk02 2859 26 Mycoplasma Mycoplasma NNP cord-014516-r59usk02 2859 27 felis felis NN cord-014516-r59usk02 2859 28 ( ( -LRB- cord-014516-r59usk02 2859 29 in in IN cord-014516-r59usk02 2859 30 addition addition NN cord-014516-r59usk02 2859 31 to to IN cord-014516-r59usk02 2859 32 being be VBG cord-014516-r59usk02 2859 33 male male JJ cord-014516-r59usk02 2859 34 and and CC cord-014516-r59usk02 2859 35 not not RB cord-014516-r59usk02 2859 36 castrated castrate VBN cord-014516-r59usk02 2859 37 ) ) -RRB- cord-014516-r59usk02 2859 38 ; ; : cord-014516-r59usk02 2859 39 conjunctivitis conjunctivitis NN cord-014516-r59usk02 2859 40 was be VBD cord-014516-r59usk02 2859 41 significantly significantly RB cord-014516-r59usk02 2859 42 associated associate VBN cord-014516-r59usk02 2859 43 to to IN cord-014516-r59usk02 2859 44 positive positive JJ cord-014516-r59usk02 2859 45 results result NNS cord-014516-r59usk02 2859 46 for for IN cord-014516-r59usk02 2859 47 FHV-1 FHV-1 NNP cord-014516-r59usk02 2859 48 and and CC cord-014516-r59usk02 2859 49 Chlamydophila Chlamydophila NNP cord-014516-r59usk02 2859 50 felis felis NN cord-014516-r59usk02 2859 51 ( ( -LRB- cord-014516-r59usk02 2859 52 in in IN cord-014516-r59usk02 2859 53 addition addition NN cord-014516-r59usk02 2859 54 to to IN cord-014516-r59usk02 2859 55 being be VBG cord-014516-r59usk02 2859 56 young young JJ cord-014516-r59usk02 2859 57 , , , cord-014516-r59usk02 2859 58 not not RB cord-014516-r59usk02 2859 59 castrated castrate VBN cord-014516-r59usk02 2859 60 and and CC cord-014516-r59usk02 2859 61 purebred purebred JJ cord-014516-r59usk02 2859 62 ) ) -RRB- cord-014516-r59usk02 2859 63 and and CC cord-014516-r59usk02 2859 64 CGS CGS NNP cord-014516-r59usk02 2859 65 was be VBD cord-014516-r59usk02 2859 66 significantly significantly RB cord-014516-r59usk02 2859 67 associated associate VBN cord-014516-r59usk02 2859 68 to to IN cord-014516-r59usk02 2859 69 positive positive JJ cord-014516-r59usk02 2859 70 results result NNS cord-014516-r59usk02 2859 71 for for IN cord-014516-r59usk02 2859 72 FCV FCV NNP cord-014516-r59usk02 2859 73 ( ( -LRB- cord-014516-r59usk02 2859 74 in in IN cord-014516-r59usk02 2859 75 addition addition NN cord-014516-r59usk02 2859 76 to to IN cord-014516-r59usk02 2859 77 being be VBG cord-014516-r59usk02 2859 78 young young JJ cord-014516-r59usk02 2859 79 , , , cord-014516-r59usk02 2859 80 male male JJ cord-014516-r59usk02 2859 81 and and CC cord-014516-r59usk02 2859 82 purebred purebred JJ cord-014516-r59usk02 2859 83 ) ) -RRB- cord-014516-r59usk02 2859 84 . . . cord-014516-r59usk02 2860 1 Not not RB cord-014516-r59usk02 2860 2 being be VBG cord-014516-r59usk02 2860 3 properly properly RB cord-014516-r59usk02 2860 4 vaccinated vaccinate VBN cord-014516-r59usk02 2860 5 was be VBD cord-014516-r59usk02 2860 6 a a DT cord-014516-r59usk02 2860 7 significant significant JJ cord-014516-r59usk02 2860 8 risk risk NN cord-014516-r59usk02 2860 9 factor factor NN cord-014516-r59usk02 2860 10 only only RB cord-014516-r59usk02 2860 11 when when WRB cord-014516-r59usk02 2860 12 all all DT cord-014516-r59usk02 2860 13 three three CD cord-014516-r59usk02 2860 14 groups group NNS cord-014516-r59usk02 2860 15 were be VBD cord-014516-r59usk02 2860 16 analyzed analyze VBN cord-014516-r59usk02 2860 17 together together RB cord-014516-r59usk02 2860 18 . . . cord-014516-r59usk02 2861 1 The the DT cord-014516-r59usk02 2861 2 number number NN cord-014516-r59usk02 2861 3 of of IN cord-014516-r59usk02 2861 4 cats cat NNS cord-014516-r59usk02 2861 5 in in IN cord-014516-r59usk02 2861 6 the the DT cord-014516-r59usk02 2861 7 household household NN cord-014516-r59usk02 2861 8 was be VBD cord-014516-r59usk02 2861 9 an an DT cord-014516-r59usk02 2861 10 independent independent JJ cord-014516-r59usk02 2861 11 risk risk NN cord-014516-r59usk02 2861 12 factor factor NN cord-014516-r59usk02 2861 13 for for IN cord-014516-r59usk02 2861 14 detecting detect VBG cord-014516-r59usk02 2861 15 each each DT cord-014516-r59usk02 2861 16 of of IN cord-014516-r59usk02 2861 17 the the DT cord-014516-r59usk02 2861 18 pathogens pathogen NNS cord-014516-r59usk02 2861 19 studied study VBD cord-014516-r59usk02 2861 20 . . . cord-014516-r59usk02 2862 1 The the DT cord-014516-r59usk02 2862 2 age age NN cord-014516-r59usk02 2862 3 was be VBD cord-014516-r59usk02 2862 4 also also RB cord-014516-r59usk02 2862 5 a a DT cord-014516-r59usk02 2862 6 significant significant JJ cord-014516-r59usk02 2862 7 factor factor NN cord-014516-r59usk02 2862 8 in in IN cord-014516-r59usk02 2862 9 cats cat NNS cord-014516-r59usk02 2862 10 with with IN cord-014516-r59usk02 2862 11 FCV FCV NNP cord-014516-r59usk02 2862 12 and and CC cord-014516-r59usk02 2862 13 Chlamydophila Chlamydophila NNP cord-014516-r59usk02 2862 14 felis felis NN cord-014516-r59usk02 2862 15 , , , cord-014516-r59usk02 2862 16 being be VBG cord-014516-r59usk02 2862 17 older old JJR cord-014516-r59usk02 2862 18 cats cat NNS cord-014516-r59usk02 2862 19 predisposed predisposed JJ cord-014516-r59usk02 2862 20 to to IN cord-014516-r59usk02 2862 21 FCV FCV NNP cord-014516-r59usk02 2862 22 and and CC cord-014516-r59usk02 2862 23 younger young JJR cord-014516-r59usk02 2862 24 cats cat NNS cord-014516-r59usk02 2862 25 predisposed predisposed JJ cord-014516-r59usk02 2862 26 to to IN cord-014516-r59usk02 2862 27 Chlamydophila Chlamydophila NNP cord-014516-r59usk02 2862 28 felis felis NN cord-014516-r59usk02 2862 29 . . . cord-014516-r59usk02 2863 1 The the DT cord-014516-r59usk02 2863 2 present present JJ cord-014516-r59usk02 2863 3 study study NN cord-014516-r59usk02 2863 4 describes describe VBZ cord-014516-r59usk02 2863 5 important important JJ cord-014516-r59usk02 2863 6 epidemiological epidemiological JJ cord-014516-r59usk02 2863 7 data datum NNS cord-014516-r59usk02 2863 8 for for IN cord-014516-r59usk02 2863 9 cats cat NNS cord-014516-r59usk02 2863 10 presenting present VBG cord-014516-r59usk02 2863 11 URTD URTD NNP cord-014516-r59usk02 2863 12 , , , cord-014516-r59usk02 2863 13 conjunctivitis conjunctivitis NN cord-014516-r59usk02 2863 14 and/or and/or CC cord-014516-r59usk02 2863 15 CGS CGS NNP cord-014516-r59usk02 2863 16 , , , cord-014516-r59usk02 2863 17 and and CC cord-014516-r59usk02 2863 18 emphasizes emphasize VBZ cord-014516-r59usk02 2863 19 the the DT cord-014516-r59usk02 2863 20 complex complex JJ cord-014516-r59usk02 2863 21 interrelationships interrelationship NNS cord-014516-r59usk02 2863 22 occurring occur VBG cord-014516-r59usk02 2863 23 among among IN cord-014516-r59usk02 2863 24 the the DT cord-014516-r59usk02 2863 25 different different JJ cord-014516-r59usk02 2863 26 pathogens pathogen NNS cord-014516-r59usk02 2863 27 . . . cord-014516-r59usk02 2864 1 Our -PRON- PRP$ cord-014516-r59usk02 2864 2 results result NNS cord-014516-r59usk02 2864 3 also also RB cord-014516-r59usk02 2864 4 support support VBP cord-014516-r59usk02 2864 5 the the DT cord-014516-r59usk02 2864 6 role role NN cord-014516-r59usk02 2864 7 of of IN cord-014516-r59usk02 2864 8 FCV FCV NNP cord-014516-r59usk02 2864 9 in in IN cord-014516-r59usk02 2864 10 cats cat NNS cord-014516-r59usk02 2864 11 with with IN cord-014516-r59usk02 2864 12 chronic chronic JJ cord-014516-r59usk02 2864 13 gingivostomatitis gingivostomatitis NN cord-014516-r59usk02 2864 14 . . . cord-014516-r59usk02 2865 1 Conflicts conflict NNS cord-014516-r59usk02 2865 2 of of IN cord-014516-r59usk02 2865 3 interest interest NN cord-014516-r59usk02 2865 4 : : : cord-014516-r59usk02 2865 5 The the DT cord-014516-r59usk02 2865 6 study study NN cord-014516-r59usk02 2865 7 was be VBD cord-014516-r59usk02 2865 8 funded fund VBN cord-014516-r59usk02 2865 9 and and CC cord-014516-r59usk02 2865 10 designed design VBN cord-014516-r59usk02 2865 11 by by IN cord-014516-r59usk02 2865 12 Merial Merial NNP cord-014516-r59usk02 2865 13 Laboratories Laboratories NNP cord-014516-r59usk02 2865 14 . . . cord-014516-r59usk02 2866 1 Reports report NNS cord-014516-r59usk02 2866 2 of of IN cord-014516-r59usk02 2866 3 methicillin methicillin NN cord-014516-r59usk02 2866 4 - - HYPH cord-014516-r59usk02 2866 5 resistant resistant JJ cord-014516-r59usk02 2866 6 staphylococci staphylococcus NNS cord-014516-r59usk02 2866 7 ( ( -LRB- cord-014516-r59usk02 2866 8 MRS MRS NNP cord-014516-r59usk02 2866 9 ) ) -RRB- cord-014516-r59usk02 2866 10 in in IN cord-014516-r59usk02 2866 11 animals animal NNS cord-014516-r59usk02 2866 12 have have VBP cord-014516-r59usk02 2866 13 become become VBN cord-014516-r59usk02 2866 14 more more RBR cord-014516-r59usk02 2866 15 frequent frequent JJ cord-014516-r59usk02 2866 16 in in IN cord-014516-r59usk02 2866 17 last last JJ cord-014516-r59usk02 2866 18 years year NNS cord-014516-r59usk02 2866 19 . . . cord-014516-r59usk02 2867 1 Various various JJ cord-014516-r59usk02 2867 2 studies study NNS cord-014516-r59usk02 2867 3 have have VBP cord-014516-r59usk02 2867 4 demonstrated demonstrate VBN cord-014516-r59usk02 2867 5 the the DT cord-014516-r59usk02 2867 6 transmission transmission NN cord-014516-r59usk02 2867 7 of of IN cord-014516-r59usk02 2867 8 MRSA MRSA NNP cord-014516-r59usk02 2867 9 between between IN cord-014516-r59usk02 2867 10 animals animal NNS cord-014516-r59usk02 2867 11 and and CC cord-014516-r59usk02 2867 12 humans human NNS cord-014516-r59usk02 2867 13 in in IN cord-014516-r59usk02 2867 14 daily daily JJ cord-014516-r59usk02 2867 15 contact contact NN cord-014516-r59usk02 2867 16 with with IN cord-014516-r59usk02 2867 17 animals animal NNS cord-014516-r59usk02 2867 18 , , , cord-014516-r59usk02 2867 19 however however RB cord-014516-r59usk02 2867 20 there there EX cord-014516-r59usk02 2867 21 is be VBZ cord-014516-r59usk02 2867 22 only only RB cord-014516-r59usk02 2867 23 limited limited JJ cord-014516-r59usk02 2867 24 data datum NNS cord-014516-r59usk02 2867 25 so so RB cord-014516-r59usk02 2867 26 far far RB cord-014516-r59usk02 2867 27 available available JJ cord-014516-r59usk02 2867 28 on on IN cord-014516-r59usk02 2867 29 the the DT cord-014516-r59usk02 2867 30 transmission transmission NN cord-014516-r59usk02 2867 31 of of IN cord-014516-r59usk02 2867 32 methicillinresistant methicillinresistant JJ cord-014516-r59usk02 2867 33 coagulase coagulase NN cord-014516-r59usk02 2867 34 - - HYPH cord-014516-r59usk02 2867 35 negative negative JJ cord-014516-r59usk02 2867 36 staphylococci staphylococcus NNS cord-014516-r59usk02 2867 37 between between IN cord-014516-r59usk02 2867 38 animals animal NNS cord-014516-r59usk02 2867 39 and and CC cord-014516-r59usk02 2867 40 humans human NNS cord-014516-r59usk02 2867 41 . . . cord-014516-r59usk02 2868 1 The the DT cord-014516-r59usk02 2868 2 objective objective NN cord-014516-r59usk02 2868 3 of of IN cord-014516-r59usk02 2868 4 this this DT cord-014516-r59usk02 2868 5 study study NN cord-014516-r59usk02 2868 6 was be VBD cord-014516-r59usk02 2868 7 to to TO cord-014516-r59usk02 2868 8 investigate investigate VB cord-014516-r59usk02 2868 9 the the DT cord-014516-r59usk02 2868 10 frequency frequency NN cord-014516-r59usk02 2868 11 of of IN cord-014516-r59usk02 2868 12 methicillin methicillin NN cord-014516-r59usk02 2868 13 - - HYPH cord-014516-r59usk02 2868 14 resistant resistant JJ cord-014516-r59usk02 2868 15 staphylococci staphylococcus NNS cord-014516-r59usk02 2868 16 ( ( -LRB- cord-014516-r59usk02 2868 17 MRS MRS NNP cord-014516-r59usk02 2868 18 ) ) -RRB- cord-014516-r59usk02 2868 19 carriage carriage NN cord-014516-r59usk02 2868 20 in in IN cord-014516-r59usk02 2868 21 healthy healthy JJ cord-014516-r59usk02 2868 22 veterinarians veterinarian NNS cord-014516-r59usk02 2868 23 , , , cord-014516-r59usk02 2868 24 veterinary veterinary JJ cord-014516-r59usk02 2868 25 nurses nurse NNS cord-014516-r59usk02 2868 26 , , , cord-014516-r59usk02 2868 27 veterinary veterinary JJ cord-014516-r59usk02 2868 28 assistants assistant NNS cord-014516-r59usk02 2868 29 , , , cord-014516-r59usk02 2868 30 veterinary veterinary JJ cord-014516-r59usk02 2868 31 students student NNS cord-014516-r59usk02 2868 32 and and CC cord-014516-r59usk02 2868 33 farm farm NN cord-014516-r59usk02 2868 34 workers worker NNS cord-014516-r59usk02 2868 35 from from IN cord-014516-r59usk02 2868 36 several several JJ cord-014516-r59usk02 2868 37 veterinary veterinary JJ cord-014516-r59usk02 2868 38 hospitals hospital NNS cord-014516-r59usk02 2868 39 , , , cord-014516-r59usk02 2868 40 clinics clinic NNS cord-014516-r59usk02 2868 41 and and CC cord-014516-r59usk02 2868 42 farms farm NNS cord-014516-r59usk02 2868 43 . . . cord-014516-r59usk02 2869 1 Nasal nasal NN cord-014516-r59usk02 2869 2 swabs swab NNS cord-014516-r59usk02 2869 3 were be VBD cord-014516-r59usk02 2869 4 collected collect VBN cord-014516-r59usk02 2869 5 from from IN cord-014516-r59usk02 2869 6 72 72 CD cord-014516-r59usk02 2869 7 veterinarians veterinarian NNS cord-014516-r59usk02 2869 8 ( ( -LRB- cord-014516-r59usk02 2869 9 60 60 CD cord-014516-r59usk02 2869 10 small small JJ cord-014516-r59usk02 2869 11 animal animal NN cord-014516-r59usk02 2869 12 veterinarians veterinarian NNS cord-014516-r59usk02 2869 13 and and CC cord-014516-r59usk02 2869 14 12 12 CD cord-014516-r59usk02 2869 15 pig pig NN cord-014516-r59usk02 2869 16 veterinarians veterinarian NNS cord-014516-r59usk02 2869 17 ) ) -RRB- cord-014516-r59usk02 2869 18 , , , cord-014516-r59usk02 2869 19 8 8 CD cord-014516-r59usk02 2869 20 veterinary veterinary JJ cord-014516-r59usk02 2869 21 nurses nurse NNS cord-014516-r59usk02 2869 22 , , , cord-014516-r59usk02 2869 23 53 53 CD cord-014516-r59usk02 2869 24 veterinary veterinary JJ cord-014516-r59usk02 2869 25 students student NNS cord-014516-r59usk02 2869 26 , , , cord-014516-r59usk02 2869 27 4 4 CD cord-014516-r59usk02 2869 28 veterinary veterinary JJ cord-014516-r59usk02 2869 29 assistants assistant NNS cord-014516-r59usk02 2869 30 and and CC cord-014516-r59usk02 2869 31 11 11 CD cord-014516-r59usk02 2869 32 farm farm NN cord-014516-r59usk02 2869 33 workers worker NNS cord-014516-r59usk02 2869 34 . . . cord-014516-r59usk02 2870 1 MRS MRS NNP cord-014516-r59usk02 2870 2 were be VBD cord-014516-r59usk02 2870 3 screened screen VBN cord-014516-r59usk02 2870 4 on on IN cord-014516-r59usk02 2870 5 Brilliance Brilliance NNP cord-014516-r59usk02 2870 6 TM TM NNP cord-014516-r59usk02 2870 7 MRSA2 MRSA2 NNP cord-014516-r59usk02 2870 8 agar agar NNP cord-014516-r59usk02 2870 9 ( ( -LRB- cord-014516-r59usk02 2870 10 Oxoid Oxoid NNP cord-014516-r59usk02 2870 11 ) ) -RRB- cord-014516-r59usk02 2870 12 or or CC cord-014516-r59usk02 2870 13 ChromID ChromID NNP cord-014516-r59usk02 2870 14 TM TM NNP cord-014516-r59usk02 2870 15 MRSA MRSA NNP cord-014516-r59usk02 2870 16 ( ( -LRB- cord-014516-r59usk02 2870 17 bioM biom JJ cord-014516-r59usk02 2870 18 erieux erieux JJ cord-014516-r59usk02 2870 19 ) ) -RRB- cord-014516-r59usk02 2870 20 . . . cord-014516-r59usk02 2871 1 After after IN cord-014516-r59usk02 2871 2 24 24 CD cord-014516-r59usk02 2871 3 - - SYM cord-014516-r59usk02 2871 4 48 48 CD cord-014516-r59usk02 2871 5 h h NN cord-014516-r59usk02 2871 6 of of IN cord-014516-r59usk02 2871 7 incubation incubation NN cord-014516-r59usk02 2871 8 at at IN cord-014516-r59usk02 2871 9 37 37 CD cord-014516-r59usk02 2871 10 ° ° NN cord-014516-r59usk02 2871 11 C c NN cord-014516-r59usk02 2871 12 , , , cord-014516-r59usk02 2871 13 suspected suspect VBN cord-014516-r59usk02 2871 14 colonies colony NNS cord-014516-r59usk02 2871 15 on on IN cord-014516-r59usk02 2871 16 both both DT cord-014516-r59usk02 2871 17 media medium NNS cord-014516-r59usk02 2871 18 were be VBD cord-014516-r59usk02 2871 19 subcultured subculture VBN cord-014516-r59usk02 2871 20 onto onto IN cord-014516-r59usk02 2871 21 blood blood NN cord-014516-r59usk02 2871 22 agar agar NN cord-014516-r59usk02 2871 23 plates plate NNS cord-014516-r59usk02 2871 24 . . . cord-014516-r59usk02 2872 1 Species specie NNS cord-014516-r59usk02 2872 2 identification identification NN cord-014516-r59usk02 2872 3 was be VBD cord-014516-r59usk02 2872 4 obtained obtain VBN cord-014516-r59usk02 2872 5 by by IN cord-014516-r59usk02 2872 6 species species NN cord-014516-r59usk02 2872 7 - - HYPH cord-014516-r59usk02 2872 8 specific specific JJ cord-014516-r59usk02 2872 9 PCR pcr NN cord-014516-r59usk02 2872 10 . . . cord-014516-r59usk02 2873 1 Methicillin methicillin NN cord-014516-r59usk02 2873 2 - - HYPH cord-014516-r59usk02 2873 3 resistance resistance NN cord-014516-r59usk02 2873 4 was be VBD cord-014516-r59usk02 2873 5 confirmed confirm VBN cord-014516-r59usk02 2873 6 by by IN cord-014516-r59usk02 2873 7 PCR PCR NNP cord-014516-r59usk02 2873 8 amplification amplification NN cord-014516-r59usk02 2873 9 of of IN cord-014516-r59usk02 2873 10 the the DT cord-014516-r59usk02 2873 11 mecA mecA NNP cord-014516-r59usk02 2873 12 gene gene NN cord-014516-r59usk02 2873 13 . . . cord-014516-r59usk02 2874 1 MRSA MRSA NNP cord-014516-r59usk02 2874 2 isolates isolate NNS cord-014516-r59usk02 2874 3 were be VBD cord-014516-r59usk02 2874 4 characterized characterize VBN cord-014516-r59usk02 2874 5 by by IN cord-014516-r59usk02 2874 6 MLST.Thirty MLST.Thirty NNP cord-014516-r59usk02 2874 7 - - HYPH cord-014516-r59usk02 2874 8 nine nine CD cord-014516-r59usk02 2875 1 MRS MRS NNP cord-014516-r59usk02 2875 2 were be VBD cord-014516-r59usk02 2875 3 identified identify VBN cord-014516-r59usk02 2875 4 in in IN cord-014516-r59usk02 2875 5 38 38 CD cord-014516-r59usk02 2875 6 humans human NNS cord-014516-r59usk02 2875 7 ( ( -LRB- cord-014516-r59usk02 2875 8 23 23 CD cord-014516-r59usk02 2875 9 veterinarians veterinarian NNS cord-014516-r59usk02 2875 10 , , , cord-014516-r59usk02 2875 11 2 2 CD cord-014516-r59usk02 2875 12 veterinary veterinary JJ cord-014516-r59usk02 2875 13 nurses nurse NNS cord-014516-r59usk02 2875 14 , , , cord-014516-r59usk02 2875 15 7 7 CD cord-014516-r59usk02 2875 16 veterinary veterinary JJ cord-014516-r59usk02 2875 17 students student NNS cord-014516-r59usk02 2875 18 , , , cord-014516-r59usk02 2875 19 2 2 CD cord-014516-r59usk02 2875 20 veterinary veterinary JJ cord-014516-r59usk02 2875 21 assistants assistant NNS cord-014516-r59usk02 2875 22 and and CC cord-014516-r59usk02 2875 23 5 5 CD cord-014516-r59usk02 2875 24 farm farm NN cord-014516-r59usk02 2875 25 workers worker NNS cord-014516-r59usk02 2875 26 ) ) -RRB- cord-014516-r59usk02 2875 27 . . . cord-014516-r59usk02 2876 1 The the DT cord-014516-r59usk02 2876 2 MRS MRS NNP cord-014516-r59usk02 2876 3 isolates isolate NNS cord-014516-r59usk02 2876 4 were be VBD cord-014516-r59usk02 2876 5 identified identify VBN cord-014516-r59usk02 2876 6 as as IN cord-014516-r59usk02 2876 7 Staphylococcus Staphylococcus NNP cord-014516-r59usk02 2876 8 aureus aureus NN cord-014516-r59usk02 2876 9 ( ( -LRB- cord-014516-r59usk02 2876 10 MRSA MRSA NNP cord-014516-r59usk02 2876 11 , , , cord-014516-r59usk02 2876 12 n n NN cord-014516-r59usk02 2876 13 = = SYM cord-014516-r59usk02 2876 14 23 23 CD cord-014516-r59usk02 2876 15 ) ) -RRB- cord-014516-r59usk02 2876 16 , , , cord-014516-r59usk02 2876 17 S. S. NNP cord-014516-r59usk02 2876 18 epidermidis epidermidi NNS cord-014516-r59usk02 2876 19 ( ( -LRB- cord-014516-r59usk02 2876 20 MRSE MRSE NNP cord-014516-r59usk02 2876 21 , , , cord-014516-r59usk02 2876 22 n n NN cord-014516-r59usk02 2876 23 = = SYM cord-014516-r59usk02 2876 24 9 9 CD cord-014516-r59usk02 2876 25 ) ) -RRB- cord-014516-r59usk02 2876 26 , , , cord-014516-r59usk02 2876 27 S. S. NNP cord-014516-r59usk02 2876 28 pseudintermedius pseudintermedius NN cord-014516-r59usk02 2876 29 ( ( -LRB- cord-014516-r59usk02 2876 30 MRSP MRSP NNP cord-014516-r59usk02 2876 31 , , , cord-014516-r59usk02 2876 32 n n NN cord-014516-r59usk02 2876 33 = = SYM cord-014516-r59usk02 2876 34 1 1 CD cord-014516-r59usk02 2876 35 ) ) -RRB- cord-014516-r59usk02 2876 36 , , , cord-014516-r59usk02 2876 37 S. S. NNP cord-014516-r59usk02 2876 38 haemolyticus haemolyticus NNP cord-014516-r59usk02 2876 39 ( ( -LRB- cord-014516-r59usk02 2876 40 MRSH MRSH NNP cord-014516-r59usk02 2876 41 , , , cord-014516-r59usk02 2876 42 n n NN cord-014516-r59usk02 2876 43 = = SYM cord-014516-r59usk02 2876 44 1 1 CD cord-014516-r59usk02 2876 45 ) ) -RRB- cord-014516-r59usk02 2876 46 and and CC cord-014516-r59usk02 2876 47 5 5 CD cord-014516-r59usk02 2876 48 MRS MRS NNP cord-014516-r59usk02 2876 49 coagulase coagulase NN cord-014516-r59usk02 2876 50 - - HYPH cord-014516-r59usk02 2876 51 negative negative JJ cord-014516-r59usk02 2876 52 staphylococci staphylococcus NNS cord-014516-r59usk02 2876 53 . . . cord-014516-r59usk02 2877 1 The the DT cord-014516-r59usk02 2877 2 frequency frequency NN cord-014516-r59usk02 2877 3 of of IN cord-014516-r59usk02 2877 4 colonization colonization NN cord-014516-r59usk02 2877 5 by by IN cord-014516-r59usk02 2877 6 MRS MRS NNP cord-014516-r59usk02 2877 7 was be VBD cord-014516-r59usk02 2877 8 similar similar JJ cord-014516-r59usk02 2877 9 in in IN cord-014516-r59usk02 2877 10 both both DT cord-014516-r59usk02 2877 11 small small JJ cord-014516-r59usk02 2877 12 animals animal NNS cord-014516-r59usk02 2877 13 and and CC cord-014516-r59usk02 2877 14 pigs pig NNS cord-014516-r59usk02 2877 15 veterinarians veterinarian NNS cord-014516-r59usk02 2877 16 ( ( -LRB- cord-014516-r59usk02 2877 17 AE AE NNP cord-014516-r59usk02 2877 18 30 30 CD cord-014516-r59usk02 2877 19 % % NN cord-014516-r59usk02 2877 20 ) ) -RRB- cord-014516-r59usk02 2877 21 . . . cord-014516-r59usk02 2878 1 One one CD cord-014516-r59usk02 2878 2 veterinary veterinary JJ cord-014516-r59usk02 2878 3 student student NN cord-014516-r59usk02 2878 4 was be VBD cord-014516-r59usk02 2878 5 colonized colonize VBN cord-014516-r59usk02 2878 6 simultaneously simultaneously RB cord-014516-r59usk02 2878 7 with with IN cord-014516-r59usk02 2878 8 an an DT cord-014516-r59usk02 2878 9 MRSE MRSE NNP cord-014516-r59usk02 2878 10 and and CC cord-014516-r59usk02 2878 11 an an DT cord-014516-r59usk02 2878 12 MRSH MRSH NNP cord-014516-r59usk02 2878 13 . . . cord-014516-r59usk02 2879 1 The the DT cord-014516-r59usk02 2879 2 predominant predominant JJ cord-014516-r59usk02 2879 3 ST ST NNP cord-014516-r59usk02 2879 4 in in IN cord-014516-r59usk02 2879 5 humans human NNS cord-014516-r59usk02 2879 6 in in IN cord-014516-r59usk02 2879 7 contact contact NN cord-014516-r59usk02 2879 8 with with IN cord-014516-r59usk02 2879 9 small small JJ cord-014516-r59usk02 2879 10 animals animal NNS cord-014516-r59usk02 2879 11 was be VBD cord-014516-r59usk02 2879 12 ST22 ST22 NNP cord-014516-r59usk02 2879 13 and and CC cord-014516-r59usk02 2879 14 in in IN cord-014516-r59usk02 2879 15 humans human NNS cord-014516-r59usk02 2879 16 in in IN cord-014516-r59usk02 2879 17 contact contact NN cord-014516-r59usk02 2879 18 with with IN cord-014516-r59usk02 2879 19 pigs pig NNS cord-014516-r59usk02 2879 20 was be VBD cord-014516-r59usk02 2879 21 ST398.In ST398.In VBN cord-014516-r59usk02 2880 1 our -PRON- PRP$ cord-014516-r59usk02 2880 2 study study NN cord-014516-r59usk02 2880 3 the the DT cord-014516-r59usk02 2880 4 frequency frequency NN cord-014516-r59usk02 2880 5 of of IN cord-014516-r59usk02 2880 6 colonization colonization NN cord-014516-r59usk02 2880 7 by by IN cord-014516-r59usk02 2880 8 MRSA MRSA NNP cord-014516-r59usk02 2880 9 was be VBD cord-014516-r59usk02 2880 10 high high JJ cord-014516-r59usk02 2880 11 , , , cord-014516-r59usk02 2880 12 but but CC cord-014516-r59usk02 2880 13 the the DT cord-014516-r59usk02 2880 14 frequency frequency NN cord-014516-r59usk02 2880 15 of of IN cord-014516-r59usk02 2880 16 MRSE MRSE NNP cord-014516-r59usk02 2880 17 should should MD cord-014516-r59usk02 2880 18 not not RB cord-014516-r59usk02 2880 19 be be VB cord-014516-r59usk02 2880 20 underestimated underestimate VBN cord-014516-r59usk02 2880 21 . . . cord-014516-r59usk02 2881 1 MRSA MRSA NNP cord-014516-r59usk02 2881 2 isolates isolate VBZ cord-014516-r59usk02 2881 3 in in IN cord-014516-r59usk02 2881 4 this this DT cord-014516-r59usk02 2881 5 work work NN cord-014516-r59usk02 2881 6 belonged belong VBD cord-014516-r59usk02 2881 7 mainly mainly RB cord-014516-r59usk02 2881 8 to to IN cord-014516-r59usk02 2881 9 the the DT cord-014516-r59usk02 2881 10 ST22 ST22 NNP cord-014516-r59usk02 2881 11 lineage lineage NN cord-014516-r59usk02 2881 12 which which WDT cord-014516-r59usk02 2881 13 is be VBZ cord-014516-r59usk02 2881 14 the the DT cord-014516-r59usk02 2881 15 most most RBS cord-014516-r59usk02 2881 16 frequent frequent JJ cord-014516-r59usk02 2881 17 in in IN cord-014516-r59usk02 2881 18 small small JJ cord-014516-r59usk02 2881 19 animals animal NNS cord-014516-r59usk02 2881 20 and and CC cord-014516-r59usk02 2881 21 humans human NNS cord-014516-r59usk02 2881 22 in in IN cord-014516-r59usk02 2881 23 Europe Europe NNP cord-014516-r59usk02 2881 24 . . . cord-014516-r59usk02 2882 1 Humans human NNS cord-014516-r59usk02 2882 2 in in IN cord-014516-r59usk02 2882 3 daily daily JJ cord-014516-r59usk02 2882 4 contact contact NN cord-014516-r59usk02 2882 5 with with IN cord-014516-r59usk02 2882 6 animals animal NNS cord-014516-r59usk02 2882 7 can can MD cord-014516-r59usk02 2882 8 become become VB cord-014516-r59usk02 2882 9 colonized colonize VBN cord-014516-r59usk02 2882 10 by by IN cord-014516-r59usk02 2882 11 MRS MRS NNP cord-014516-r59usk02 2882 12 of of IN cord-014516-r59usk02 2882 13 animal animal NN cord-014516-r59usk02 2882 14 origin origin NN cord-014516-r59usk02 2882 15 and and CC cord-014516-r59usk02 2882 16 thus thus RB cord-014516-r59usk02 2882 17 are be VBP cord-014516-r59usk02 2882 18 important important JJ cord-014516-r59usk02 2882 19 keys key NNS cord-014516-r59usk02 2882 20 for for IN cord-014516-r59usk02 2882 21 infection infection NN cord-014516-r59usk02 2882 22 control control NN cord-014516-r59usk02 2882 23 programs program NNS cord-014516-r59usk02 2882 24 in in IN cord-014516-r59usk02 2882 25 Veterinary Veterinary NNP cord-014516-r59usk02 2882 26 Hospitals Hospitals NNPS cord-014516-r59usk02 2882 27 and and CC cord-014516-r59usk02 2882 28 Farms Farms NNPS cord-014516-r59usk02 2882 29 . . . cord-014516-r59usk02 2883 1 Conflicts conflict NNS cord-014516-r59usk02 2883 2 of of IN cord-014516-r59usk02 2883 3 interest interest NN cord-014516-r59usk02 2883 4 : : : cord-014516-r59usk02 2883 5 Dr Dr NNP cord-014516-r59usk02 2883 6 Pomba Pomba NNP cord-014516-r59usk02 2883 7 currently currently RB cord-014516-r59usk02 2883 8 receives receive VBZ cord-014516-r59usk02 2883 9 research research NN cord-014516-r59usk02 2883 10 funding funding NN cord-014516-r59usk02 2883 11 from from IN cord-014516-r59usk02 2883 12 the the DT cord-014516-r59usk02 2883 13 government government NN cord-014516-r59usk02 2883 14 and and CC cord-014516-r59usk02 2883 15 national national JJ cord-014516-r59usk02 2883 16 programmes programme NNS cord-014516-r59usk02 2883 17 ( ( -LRB- cord-014516-r59usk02 2883 18 Fundac Fundac NNP cord-014516-r59usk02 2883 19 ßão ßão NNS cord-014516-r59usk02 2883 20 para para NNP cord-014516-r59usk02 2883 21 a a DT cord-014516-r59usk02 2883 22 Ciência Ciência NNP cord-014516-r59usk02 2883 23 e e NN cord-014516-r59usk02 2883 24 a a DT cord-014516-r59usk02 2883 25 Tecnologia Tecnologia NNP cord-014516-r59usk02 2883 26 ) ) -RRB- cord-014516-r59usk02 2883 27 . . . cord-014516-r59usk02 2884 1 In in IN cord-014516-r59usk02 2884 2 the the DT cord-014516-r59usk02 2884 3 past past NN cord-014516-r59usk02 2884 4 , , , cord-014516-r59usk02 2884 5 she -PRON- PRP cord-014516-r59usk02 2884 6 has have VBZ cord-014516-r59usk02 2884 7 occasionally occasionally RB cord-014516-r59usk02 2884 8 received receive VBN cord-014516-r59usk02 2884 9 research research NN cord-014516-r59usk02 2884 10 support support NN cord-014516-r59usk02 2884 11 or or CC cord-014516-r59usk02 2884 12 honoraria honoraria NN cord-014516-r59usk02 2884 13 for for IN cord-014516-r59usk02 2884 14 lectures lecture NNS cord-014516-r59usk02 2884 15 from from IN cord-014516-r59usk02 2884 16 pharmaceutical pharmaceutical JJ cord-014516-r59usk02 2884 17 companies company NNS cord-014516-r59usk02 2884 18 including include VBG cord-014516-r59usk02 2884 19 Zoetis Zoetis NNP cord-014516-r59usk02 2884 20 and and CC cord-014516-r59usk02 2884 21 Atral Atral NNP cord-014516-r59usk02 2884 22 Cipan Cipan NNP cord-014516-r59usk02 2884 23 . . . cord-014516-r59usk02 2885 1 She -PRON- PRP cord-014516-r59usk02 2885 2 is be VBZ cord-014516-r59usk02 2885 3 vice vice NN cord-014516-r59usk02 2885 4 - - HYPH cord-014516-r59usk02 2885 5 chair chair NN cord-014516-r59usk02 2885 6 of of IN cord-014516-r59usk02 2885 7 the the DT cord-014516-r59usk02 2885 8 Antimicrobial Antimicrobial NNP cord-014516-r59usk02 2885 9 Working Working NNP cord-014516-r59usk02 2885 10 Party Party NNP cord-014516-r59usk02 2885 11 ( ( -LRB- cord-014516-r59usk02 2885 12 AWP AWP NNP cord-014516-r59usk02 2885 13 ) ) -RRB- cord-014516-r59usk02 2885 14 and and CC cord-014516-r59usk02 2885 15 member member NN cord-014516-r59usk02 2885 16 of of IN cord-014516-r59usk02 2885 17 the the DT cord-014516-r59usk02 2885 18 Antimicrobial Antimicrobial NNP cord-014516-r59usk02 2885 19 Advice Advice NNP cord-014516-r59usk02 2885 20 ad ad FW cord-014516-r59usk02 2885 21 hoc hoc FW cord-014516-r59usk02 2885 22 Expert expert NN cord-014516-r59usk02 2885 23 group group NN cord-014516-r59usk02 2885 24 ( ( -LRB- cord-014516-r59usk02 2885 25 AMEG AMEG NNP cord-014516-r59usk02 2885 26 ) ) -RRB- cord-014516-r59usk02 2885 27 of of IN cord-014516-r59usk02 2885 28 the the DT cord-014516-r59usk02 2885 29 European European NNP cord-014516-r59usk02 2885 30 Medicines Medicines NNPS cord-014516-r59usk02 2885 31 Agency Agency NNP cord-014516-r59usk02 2885 32 ( ( -LRB- cord-014516-r59usk02 2885 33 EMA EMA NNP cord-014516-r59usk02 2885 34 ) ) -RRB- cord-014516-r59usk02 2885 35 . . . cord-014516-r59usk02 2886 1 , , , cord-014516-r59usk02 2886 2 species specie NNS cord-014516-r59usk02 2886 3 not not RB cord-014516-r59usk02 2886 4 determined determine VBN cord-014516-r59usk02 2886 5 [ [ -LRB- cord-014516-r59usk02 2886 6 2 2 CD cord-014516-r59usk02 2886 7 ] ] -RRB- cord-014516-r59usk02 2886 8 ) ) -RRB- cord-014516-r59usk02 2886 9 did do VBD cord-014516-r59usk02 2886 10 not not RB cord-014516-r59usk02 2886 11 . . . cord-014516-r59usk02 2887 1 All all DT cord-014516-r59usk02 2887 2 17 17 CD cord-014516-r59usk02 2887 3 cats cat NNS cord-014516-r59usk02 2887 4 underwent undergo VBD cord-014516-r59usk02 2887 5 antibiotic antibiotic JJ cord-014516-r59usk02 2887 6 treatment treatment NN cord-014516-r59usk02 2887 7 ( ( -LRB- cord-014516-r59usk02 2887 8 doxycycline doxycycline NNP cord-014516-r59usk02 2887 9 or or CC cord-014516-r59usk02 2887 10 a a DT cord-014516-r59usk02 2887 11 fluoroquinolone fluoroquinolone NN cord-014516-r59usk02 2887 12 ) ) -RRB- cord-014516-r59usk02 2887 13 ; ; : cord-014516-r59usk02 2887 14 12 12 CD cord-014516-r59usk02 2887 15 cats cat NNS cord-014516-r59usk02 2887 16 received receive VBD cord-014516-r59usk02 2887 17 blood blood NN cord-014516-r59usk02 2887 18 transfusions transfusion NNS cord-014516-r59usk02 2887 19 and/or and/or CC cord-014516-r59usk02 2888 1 Oxyglobin Oxyglobin NNP cord-014516-r59usk02 2888 2 â â NNP cord-014516-r59usk02 2888 3 . . . cord-014516-r59usk02 2889 1 Three three CD cord-014516-r59usk02 2889 2 cats cat NNS cord-014516-r59usk02 2889 3 were be VBD cord-014516-r59usk02 2889 4 euthanatized euthanatize VBN cord-014516-r59usk02 2889 5 within within IN cord-014516-r59usk02 2889 6 11 11 CD cord-014516-r59usk02 2889 7 days day NNS cord-014516-r59usk02 2889 8 due due JJ cord-014516-r59usk02 2889 9 to to IN cord-014516-r59usk02 2889 10 concurrent concurrent JJ cord-014516-r59usk02 2889 11 disease disease NN cord-014516-r59usk02 2889 12 ( ( -LRB- cord-014516-r59usk02 2889 13 FIV fiv NN cord-014516-r59usk02 2889 14 , , , cord-014516-r59usk02 2889 15 pancreatitis pancreatitis NN cord-014516-r59usk02 2889 16 / / SYM cord-014516-r59usk02 2889 17 cholangitis cholangitis NN cord-014516-r59usk02 2889 18 ) ) -RRB- cord-014516-r59usk02 2889 19 or or CC cord-014516-r59usk02 2889 20 financial financial JJ cord-014516-r59usk02 2889 21 constraints constraint NNS cord-014516-r59usk02 2889 22 , , , cord-014516-r59usk02 2889 23 one one CD cord-014516-r59usk02 2889 24 cat cat NN cord-014516-r59usk02 2889 25 due due JJ cord-014516-r59usk02 2889 26 to to IN cord-014516-r59usk02 2889 27 persistent persistent JJ cord-014516-r59usk02 2889 28 anemia anemia NN cord-014516-r59usk02 2889 29 after after IN cord-014516-r59usk02 2889 30 11 11 CD cord-014516-r59usk02 2889 31 weeks week NNS cord-014516-r59usk02 2889 32 . . . cord-014516-r59usk02 2890 1 Four four CD cord-014516-r59usk02 2890 2 cats cat NNS cord-014516-r59usk02 2890 3 were be VBD cord-014516-r59usk02 2890 4 lost lose VBN cord-014516-r59usk02 2890 5 to to TO cord-014516-r59usk02 2890 6 follow follow VB cord-014516-r59usk02 2890 7 - - HYPH cord-014516-r59usk02 2890 8 up up NN cord-014516-r59usk02 2890 9 . . . cord-014516-r59usk02 2891 1 The the DT cord-014516-r59usk02 2891 2 remaining remain VBG cord-014516-r59usk02 2891 3 9 9 CD cord-014516-r59usk02 2891 4 cats cat NNS cord-014516-r59usk02 2891 5 underwent undergo VBD cord-014516-r59usk02 2891 6 follow follow NN cord-014516-r59usk02 2891 7 - - HYPH cord-014516-r59usk02 2891 8 up up NN cord-014516-r59usk02 2891 9 for for IN cord-014516-r59usk02 2891 10 a a DT cord-014516-r59usk02 2891 11 period period NN cord-014516-r59usk02 2891 12 of of IN cord-014516-r59usk02 2891 13 11 11 CD cord-014516-r59usk02 2891 14 - - SYM cord-014516-r59usk02 2891 15 199 199 CD cord-014516-r59usk02 2891 16 weeks week NNS cord-014516-r59usk02 2891 17 ( ( -LRB- cord-014516-r59usk02 2891 18 median median JJ cord-014516-r59usk02 2891 19 24 24 CD cord-014516-r59usk02 2891 20 ) ) -RRB- cord-014516-r59usk02 2891 21 . . . cord-014516-r59usk02 2892 1 Hemoplasma Hemoplasma NNP cord-014516-r59usk02 2892 2 PCR PCR NNP cord-014516-r59usk02 2892 3 analysis analysis NN cord-014516-r59usk02 2892 4 was be VBD cord-014516-r59usk02 2892 5 conducted conduct VBN cord-014516-r59usk02 2892 6 2 2 CD cord-014516-r59usk02 2892 7 - - SYM cord-014516-r59usk02 2892 8 7 7 CD cord-014516-r59usk02 2892 9 times time NNS cord-014516-r59usk02 2892 10 on on IN cord-014516-r59usk02 2892 11 blood blood NN cord-014516-r59usk02 2892 12 samples sample NNS cord-014516-r59usk02 2892 13 at at IN cord-014516-r59usk02 2892 14 variable variable JJ cord-014516-r59usk02 2892 15 time time NN cord-014516-r59usk02 2892 16 points point VBZ cord-014516-r59usk02 2892 17 from from IN cord-014516-r59usk02 2892 18 6 6 CD cord-014516-r59usk02 2892 19 of of IN cord-014516-r59usk02 2892 20 the the DT cord-014516-r59usk02 2892 21 9 9 CD cord-014516-r59usk02 2892 22 follow follow VB cord-014516-r59usk02 2892 23 - - HYPH cord-014516-r59usk02 2892 24 up up RP cord-014516-r59usk02 2892 25 cats cat NNS cord-014516-r59usk02 2892 26 . . . cord-014516-r59usk02 2893 1 The the DT cord-014516-r59usk02 2893 2 first first JJ cord-014516-r59usk02 2893 3 negative negative JJ cord-014516-r59usk02 2893 4 PCR pcr NN cord-014516-r59usk02 2893 5 in in IN cord-014516-r59usk02 2893 6 4 4 CD cord-014516-r59usk02 2893 7 cases case NNS cord-014516-r59usk02 2893 8 occurred occur VBD cord-014516-r59usk02 2893 9 after after IN cord-014516-r59usk02 2893 10 3 3 CD cord-014516-r59usk02 2894 1 ( ( -LRB- cord-014516-r59usk02 2894 2 CMhm CMhm NNP cord-014516-r59usk02 2894 3 , , , cord-014516-r59usk02 2894 4 during during IN cord-014516-r59usk02 2894 5 antibiotic antibiotic JJ cord-014516-r59usk02 2894 6 treatment treatment NN cord-014516-r59usk02 2894 7 ) ) -RRB- cord-014516-r59usk02 2894 8 , , , cord-014516-r59usk02 2894 9 7 7 CD cord-014516-r59usk02 2894 10 ( ( -LRB- cord-014516-r59usk02 2894 11 CMhm CMhm NNP cord-014516-r59usk02 2894 12 , , , cord-014516-r59usk02 2894 13 during during IN cord-014516-r59usk02 2894 14 antibiotic antibiotic JJ cord-014516-r59usk02 2894 15 treatment treatment NN cord-014516-r59usk02 2894 16 ) ) -RRB- cord-014516-r59usk02 2894 17 , , , cord-014516-r59usk02 2894 18 10 10 CD cord-014516-r59usk02 2894 19 ( ( -LRB- cord-014516-r59usk02 2894 20 CMhm CMhm NNP cord-014516-r59usk02 2894 21 , , , cord-014516-r59usk02 2894 22 during during IN cord-014516-r59usk02 2894 23 antibiotic antibiotic JJ cord-014516-r59usk02 2894 24 treatment treatment NN cord-014516-r59usk02 2894 25 ) ) -RRB- cord-014516-r59usk02 2894 26 and and CC cord-014516-r59usk02 2894 27 23 23 CD cord-014516-r59usk02 2894 28 ( ( -LRB- cord-014516-r59usk02 2894 29 Mhf Mhf NNP cord-014516-r59usk02 2894 30 , , , cord-014516-r59usk02 2894 31 after after IN cord-014516-r59usk02 2894 32 completion completion NN cord-014516-r59usk02 2894 33 of of IN cord-014516-r59usk02 2894 34 antibiotics antibiotic NNS cord-014516-r59usk02 2894 35 ) ) -RRB- cord-014516-r59usk02 2894 36 weeks week NNS cord-014516-r59usk02 2894 37 . . . cord-014516-r59usk02 2895 1 One one CD cord-014516-r59usk02 2895 2 cat cat NN cord-014516-r59usk02 2895 3 remained remain VBD cord-014516-r59usk02 2895 4 PCR PCR NNP cord-014516-r59usk02 2895 5 positive positive JJ cord-014516-r59usk02 2895 6 ( ( -LRB- cord-014516-r59usk02 2895 7 CMhm CMhm NNP cord-014516-r59usk02 2895 8 ) ) -RRB- cord-014516-r59usk02 2895 9 at at IN cord-014516-r59usk02 2895 10 4 4 CD cord-014516-r59usk02 2895 11 , , , cord-014516-r59usk02 2895 12 13 13 CD cord-014516-r59usk02 2895 13 , , , cord-014516-r59usk02 2895 14 and and CC cord-014516-r59usk02 2895 15 18 18 CD cord-014516-r59usk02 2895 16 ( ( -LRB- cord-014516-r59usk02 2895 17 all all DT cord-014516-r59usk02 2895 18 during during IN cord-014516-r59usk02 2895 19 antibiotic antibiotic JJ cord-014516-r59usk02 2895 20 treatment treatment NN cord-014516-r59usk02 2895 21 ) ) -RRB- cord-014516-r59usk02 2895 22 weeks week NNS cord-014516-r59usk02 2895 23 , , , cord-014516-r59usk02 2895 24 and and CC cord-014516-r59usk02 2895 25 another another DT cord-014516-r59usk02 2895 26 cat cat NN cord-014516-r59usk02 2895 27 ( ( -LRB- cord-014516-r59usk02 2895 28 CMhm CMhm NNP cord-014516-r59usk02 2895 29 ) ) -RRB- cord-014516-r59usk02 2895 30 was be VBD cord-014516-r59usk02 2895 31 PCR PCR NNP cord-014516-r59usk02 2895 32 positive positive JJ cord-014516-r59usk02 2895 33 at at IN cord-014516-r59usk02 2895 34 199 199 CD cord-014516-r59usk02 2895 35 weeks week NNS cord-014516-r59usk02 2895 36 . . . cord-014516-r59usk02 2896 1 Reactivation reactivation NN cord-014516-r59usk02 2896 2 of of IN cord-014516-r59usk02 2896 3 the the DT cord-014516-r59usk02 2896 4 hemoplasma hemoplasma NNP cord-014516-r59usk02 2896 5 species specie NNS cord-014516-r59usk02 2896 6 ( ( -LRB- cord-014516-r59usk02 2896 7 documented document VBN cord-014516-r59usk02 2896 8 by by IN cord-014516-r59usk02 2896 9 hemolysis hemolysis NN cord-014516-r59usk02 2896 10 and and CC cord-014516-r59usk02 2896 11 positive positive JJ cord-014516-r59usk02 2896 12 PCR PCR NNP cord-014516-r59usk02 2896 13 ) ) -RRB- cord-014516-r59usk02 2896 14 occurred occur VBD cord-014516-r59usk02 2896 15 in in IN cord-014516-r59usk02 2896 16 2 2 CD cord-014516-r59usk02 2896 17 cats cat NNS cord-014516-r59usk02 2896 18 ( ( -LRB- cord-014516-r59usk02 2896 19 both both DT cord-014516-r59usk02 2896 20 CMhm CMhm NNP cord-014516-r59usk02 2896 21 ) ) -RRB- cord-014516-r59usk02 2896 22 1 1 CD cord-014516-r59usk02 2896 23 and and CC cord-014516-r59usk02 2896 24 3 3 CD cord-014516-r59usk02 2896 25 times time NNS cord-014516-r59usk02 2896 26 , , , cord-014516-r59usk02 2896 27 respectively respectively RB cord-014516-r59usk02 2896 28 , , , cord-014516-r59usk02 2896 29 up up IN cord-014516-r59usk02 2896 30 to to TO cord-014516-r59usk02 2896 31 177 177 CD cord-014516-r59usk02 2896 32 weeks week NNS cord-014516-r59usk02 2896 33 after after IN cord-014516-r59usk02 2896 34 initial initial JJ cord-014516-r59usk02 2896 35 presentation presentation NN cord-014516-r59usk02 2896 36 . . . cord-014516-r59usk02 2897 1 Reactivation reactivation NN cord-014516-r59usk02 2897 2 was be VBD cord-014516-r59usk02 2897 3 suspected suspect VBN cord-014516-r59usk02 2897 4 ( ( -LRB- cord-014516-r59usk02 2897 5 no no DT cord-014516-r59usk02 2897 6 PCR PCR NNP cord-014516-r59usk02 2897 7 testing testing NN cord-014516-r59usk02 2897 8 available available JJ cord-014516-r59usk02 2897 9 ) ) -RRB- cord-014516-r59usk02 2897 10 in in IN cord-014516-r59usk02 2897 11 2 2 CD cord-014516-r59usk02 2897 12 additional additional JJ cord-014516-r59usk02 2897 13 cases case NNS cord-014516-r59usk02 2897 14 ( ( -LRB- cord-014516-r59usk02 2897 15 CMhm CMhm NNP cord-014516-r59usk02 2897 16 [ [ -LRB- cord-014516-r59usk02 2897 17 1 1 CD cord-014516-r59usk02 2897 18 ] ] -RRB- cord-014516-r59usk02 2897 19 , , . cord-014516-r59usk02 2898 1 Mhf Mhf NNP cord-014516-r59usk02 2898 2 [ [ -LRB- cord-014516-r59usk02 2898 3 1 1 CD cord-014516-r59usk02 2898 4 ] ] -RRB- cord-014516-r59usk02 2898 5 ) ) -RRB- cord-014516-r59usk02 2898 6 . . . cord-014516-r59usk02 2899 1 Four four CD cord-014516-r59usk02 2899 2 of of IN cord-014516-r59usk02 2899 3 the the DT cord-014516-r59usk02 2899 4 9 9 CD cord-014516-r59usk02 2899 5 follow follow VB cord-014516-r59usk02 2899 6 - - HYPH cord-014516-r59usk02 2899 7 up up RP cord-014516-r59usk02 2899 8 cats cat NNS cord-014516-r59usk02 2899 9 were be VBD cord-014516-r59usk02 2899 10 euthanatized euthanatize VBN cord-014516-r59usk02 2899 11 after after IN cord-014516-r59usk02 2899 12 14 14 CD cord-014516-r59usk02 2899 13 - - SYM cord-014516-r59usk02 2899 14 180 180 CD cord-014516-r59usk02 2899 15 weeks week NNS cord-014516-r59usk02 2899 16 ( ( -LRB- cord-014516-r59usk02 2899 17 median median JJ cord-014516-r59usk02 2899 18 24 24 CD cord-014516-r59usk02 2899 19 ) ) -RRB- cord-014516-r59usk02 2899 20 due due JJ cord-014516-r59usk02 2899 21 to to IN cord-014516-r59usk02 2899 22 concurrent concurrent JJ cord-014516-r59usk02 2899 23 disease disease NN cord-014516-r59usk02 2899 24 ( ( -LRB- cord-014516-r59usk02 2899 25 cardiomyopathy cardiomyopathy NN cord-014516-r59usk02 2899 26 , , , cord-014516-r59usk02 2899 27 immune immune NN cord-014516-r59usk02 2899 28 - - HYPH cord-014516-r59usk02 2899 29 mediated mediate VBN cord-014516-r59usk02 2899 30 thrombocytopenia thrombocytopenia NN cord-014516-r59usk02 2899 31 , , , cord-014516-r59usk02 2899 32 postoperative postoperative JJ cord-014516-r59usk02 2899 33 complications complication NNS cord-014516-r59usk02 2899 34 , , , cord-014516-r59usk02 2899 35 diabetes diabete VBZ cord-014516-r59usk02 2899 36 mellitus mellitus NN cord-014516-r59usk02 2899 37 ) ) -RRB- cord-014516-r59usk02 2899 38 . . . cord-014516-r59usk02 2900 1 Infection infection NN cord-014516-r59usk02 2900 2 with with IN cord-014516-r59usk02 2900 3 hemoplasmas hemoplasmas NNP cord-014516-r59usk02 2900 4 is be VBZ cord-014516-r59usk02 2900 5 often often RB cord-014516-r59usk02 2900 6 chronic chronic JJ cord-014516-r59usk02 2900 7 , , , cord-014516-r59usk02 2900 8 can can MD cord-014516-r59usk02 2900 9 reactivate reactivate VB cord-014516-r59usk02 2900 10 months month NNS cord-014516-r59usk02 2900 11 later later RB cord-014516-r59usk02 2900 12 and and CC cord-014516-r59usk02 2900 13 is be VBZ cord-014516-r59usk02 2900 14 rarely rarely RB cord-014516-r59usk02 2900 15 the the DT cord-014516-r59usk02 2900 16 reason reason NN cord-014516-r59usk02 2900 17 for for IN cord-014516-r59usk02 2900 18 euthanasia euthanasia NN cord-014516-r59usk02 2900 19 . . . cord-014516-r59usk02 2901 1 No no DT cord-014516-r59usk02 2901 2 conflicts conflict NNS cord-014516-r59usk02 2901 3 of of IN cord-014516-r59usk02 2901 4 interest interest NN cord-014516-r59usk02 2901 5 reported report VBN cord-014516-r59usk02 2901 6 . . . cord-014516-r59usk02 2902 1 Canine canine JJ cord-014516-r59usk02 2902 2 distemper distemper NN cord-014516-r59usk02 2902 3 ( ( -LRB- cord-014516-r59usk02 2902 4 CD CD NNP cord-014516-r59usk02 2902 5 ) ) -RRB- cord-014516-r59usk02 2902 6 is be VBZ cord-014516-r59usk02 2902 7 a a DT cord-014516-r59usk02 2902 8 worldwide worldwide RB cord-014516-r59usk02 2902 9 occurring occur VBG cord-014516-r59usk02 2902 10 infectious infectious JJ cord-014516-r59usk02 2902 11 disease disease NN cord-014516-r59usk02 2902 12 caused cause VBN cord-014516-r59usk02 2902 13 by by IN cord-014516-r59usk02 2902 14 a a DT cord-014516-r59usk02 2902 15 morbillivirus morbillivirus NNP cord-014516-r59usk02 2902 16 of of IN cord-014516-r59usk02 2902 17 the the DT cord-014516-r59usk02 2902 18 family family NN cord-014516-r59usk02 2902 19 Paramyxoviridae Paramyxoviridae NNP cord-014516-r59usk02 2902 20 . . . cord-014516-r59usk02 2903 1 CDV CDV NNP cord-014516-r59usk02 2903 2 infection infection NN cord-014516-r59usk02 2903 3 can can MD cord-014516-r59usk02 2903 4 result result VB cord-014516-r59usk02 2903 5 in in IN cord-014516-r59usk02 2903 6 a a DT cord-014516-r59usk02 2903 7 systemic systemic JJ cord-014516-r59usk02 2903 8 infection infection NN cord-014516-r59usk02 2903 9 . . . cord-014516-r59usk02 2904 1 Dogs dog NNS cord-014516-r59usk02 2904 2 presented present VBN cord-014516-r59usk02 2904 3 with with IN cord-014516-r59usk02 2904 4 neurologic neurologic JJ cord-014516-r59usk02 2904 5 signs sign NNS cord-014516-r59usk02 2904 6 revealed reveal VBD cord-014516-r59usk02 2904 7 the the DT cord-014516-r59usk02 2904 8 terminal terminal JJ cord-014516-r59usk02 2904 9 stage stage NN cord-014516-r59usk02 2904 10 of of IN cord-014516-r59usk02 2904 11 the the DT cord-014516-r59usk02 2904 12 disease disease NN cord-014516-r59usk02 2904 13 and and CC cord-014516-r59usk02 2904 14 usually usually RB cord-014516-r59usk02 2904 15 failed fail VBD cord-014516-r59usk02 2904 16 to to IN cord-014516-r59usk02 2904 17 therapy therapy NN cord-014516-r59usk02 2904 18 . . . cord-014516-r59usk02 2905 1 Additional additional JJ cord-014516-r59usk02 2905 2 passive passive JJ cord-014516-r59usk02 2905 3 immunotherapy immunotherapy NN cord-014516-r59usk02 2905 4 is be VBZ cord-014516-r59usk02 2905 5 hypothesized hypothesize VBN cord-014516-r59usk02 2905 6 to to TO cord-014516-r59usk02 2905 7 be be VB cord-014516-r59usk02 2905 8 beneficial beneficial JJ cord-014516-r59usk02 2905 9 in in IN cord-014516-r59usk02 2905 10 the the DT cord-014516-r59usk02 2905 11 early early JJ cord-014516-r59usk02 2905 12 stage stage NN cord-014516-r59usk02 2905 13 of of IN cord-014516-r59usk02 2905 14 CDV CDV NNP cord-014516-r59usk02 2905 15 infection infection NN cord-014516-r59usk02 2905 16 . . . cord-014516-r59usk02 2906 1 Porcine porcine JJ cord-014516-r59usk02 2906 2 anti anti JJ cord-014516-r59usk02 2906 3 - - JJ cord-014516-r59usk02 2906 4 CDV cdv JJ cord-014516-r59usk02 2906 5 antibody antibody NN cord-014516-r59usk02 2906 6 subunit subunit NN cord-014516-r59usk02 2906 7 F F NNP cord-014516-r59usk02 2906 8 ( ( -LRB- cord-014516-r59usk02 2906 9 ab ab NNP cord-014516-r59usk02 2906 10 ' ' '' cord-014516-r59usk02 2906 11 ) ) -RRB- cord-014516-r59usk02 2906 12 2 2 CD cord-014516-r59usk02 2906 13 [ [ -LRB- cord-014516-r59usk02 2906 14 F(ab f(ab NN cord-014516-r59usk02 2906 15 ' ' '' cord-014516-r59usk02 2906 16 ) ) -RRB- cord-014516-r59usk02 2906 17 2 2 CD cord-014516-r59usk02 2906 18 ] ] -RRB- cord-014516-r59usk02 2906 19 was be VBD cord-014516-r59usk02 2906 20 produced produce VBN cord-014516-r59usk02 2906 21 by by IN cord-014516-r59usk02 2906 22 Animal Animal NNP cord-014516-r59usk02 2906 23 Technology Technology NNP cord-014516-r59usk02 2906 24 Laboratories Laboratories NNPS cord-014516-r59usk02 2906 25 , , , cord-014516-r59usk02 2906 26 Agriculture Agriculture NNP cord-014516-r59usk02 2906 27 Technology Technology NNP cord-014516-r59usk02 2906 28 Research Research NNP cord-014516-r59usk02 2906 29 Institute Institute NNP cord-014516-r59usk02 2906 30 . . . cord-014516-r59usk02 2907 1 Eighteen eighteen CD cord-014516-r59usk02 2907 2 CDVnaturally cdvnaturally RB cord-014516-r59usk02 2907 3 infected infected JJ cord-014516-r59usk02 2907 4 dogs dog NNS cord-014516-r59usk02 2907 5 showing show VBG cord-014516-r59usk02 2907 6 respiratory respiratory JJ cord-014516-r59usk02 2907 7 signs sign NNS cord-014516-r59usk02 2907 8 but but CC cord-014516-r59usk02 2907 9 no no DT cord-014516-r59usk02 2907 10 neurological neurological JJ cord-014516-r59usk02 2907 11 signs sign NNS cord-014516-r59usk02 2907 12 were be VBD cord-014516-r59usk02 2907 13 treated treat VBN cord-014516-r59usk02 2907 14 with with IN cord-014516-r59usk02 2907 15 the the DT cord-014516-r59usk02 2907 16 combination combination NN cord-014516-r59usk02 2907 17 of of IN cord-014516-r59usk02 2907 18 F(ab f(ab NN cord-014516-r59usk02 2907 19 ' ' '' cord-014516-r59usk02 2907 20 ) ) -RRB- cord-014516-r59usk02 2907 21 2 2 CD cord-014516-r59usk02 2907 22 and and CC cord-014516-r59usk02 2907 23 supportive supportive JJ cord-014516-r59usk02 2907 24 therapy therapy NN cord-014516-r59usk02 2907 25 ( ( -LRB- cord-014516-r59usk02 2907 26 group group NN cord-014516-r59usk02 2907 27 1 1 CD cord-014516-r59usk02 2907 28 ) ) -RRB- cord-014516-r59usk02 2907 29 . . . cord-014516-r59usk02 2908 1 Group group NN cord-014516-r59usk02 2908 2 2 2 CD cord-014516-r59usk02 2908 3 included include VBD cord-014516-r59usk02 2908 4 33 33 CD cord-014516-r59usk02 2908 5 dogs dog NNS cord-014516-r59usk02 2908 6 in in IN cord-014516-r59usk02 2908 7 a a DT cord-014516-r59usk02 2908 8 similar similar JJ cord-014516-r59usk02 2908 9 clinical clinical JJ cord-014516-r59usk02 2908 10 signs sign NNS cord-014516-r59usk02 2908 11 ( ( -LRB- cord-014516-r59usk02 2908 12 without without IN cord-014516-r59usk02 2908 13 neurological neurological JJ cord-014516-r59usk02 2908 14 signs sign NNS cord-014516-r59usk02 2908 15 ) ) -RRB- cord-014516-r59usk02 2908 16 that that WDT cord-014516-r59usk02 2908 17 received receive VBD cord-014516-r59usk02 2908 18 only only RB cord-014516-r59usk02 2908 19 supportive supportive JJ cord-014516-r59usk02 2908 20 therapy therapy NN cord-014516-r59usk02 2908 21 . . . cord-014516-r59usk02 2909 1 The the DT cord-014516-r59usk02 2909 2 survival survival NN cord-014516-r59usk02 2909 3 rate rate NN cord-014516-r59usk02 2909 4 was be VBD cord-014516-r59usk02 2909 5 72.2 72.2 CD cord-014516-r59usk02 2909 6 % % NN cord-014516-r59usk02 2909 7 ( ( -LRB- cord-014516-r59usk02 2909 8 13/18 13/18 CD cord-014516-r59usk02 2909 9 ) ) -RRB- cord-014516-r59usk02 2909 10 in in IN cord-014516-r59usk02 2909 11 group group NN cord-014516-r59usk02 2909 12 1 1 CD cord-014516-r59usk02 2909 13 and and CC cord-014516-r59usk02 2909 14 33.3 33.3 CD cord-014516-r59usk02 2909 15 % % NN cord-014516-r59usk02 2909 16 ( ( -LRB- cord-014516-r59usk02 2909 17 11/33 11/33 CD cord-014516-r59usk02 2909 18 ) ) -RRB- cord-014516-r59usk02 2909 19 in in IN cord-014516-r59usk02 2909 20 group group NN cord-014516-r59usk02 2909 21 2 2 CD cord-014516-r59usk02 2909 22 , , , cord-014516-r59usk02 2909 23 respectively respectively RB cord-014516-r59usk02 2909 24 , , , cord-014516-r59usk02 2909 25 with with IN cord-014516-r59usk02 2909 26 a a DT cord-014516-r59usk02 2909 27 significant significant JJ cord-014516-r59usk02 2909 28 difference difference NN cord-014516-r59usk02 2909 29 between between IN cord-014516-r59usk02 2909 30 the the DT cord-014516-r59usk02 2909 31 two two CD cord-014516-r59usk02 2909 32 groups group NNS cord-014516-r59usk02 2909 33 ( ( -LRB- cord-014516-r59usk02 2909 34 p p NN cord-014516-r59usk02 2909 35 < < XX cord-014516-r59usk02 2909 36 0.05 0.05 CD cord-014516-r59usk02 2909 37 ) ) -RRB- cord-014516-r59usk02 2909 38 . . . cord-014516-r59usk02 2910 1 The the DT cord-014516-r59usk02 2910 2 progressive progressive JJ cord-014516-r59usk02 2910 3 rates rate NNS cord-014516-r59usk02 2910 4 of of IN cord-014516-r59usk02 2910 5 developing develop VBG cord-014516-r59usk02 2910 6 neurological neurological JJ cord-014516-r59usk02 2910 7 signs sign NNS cord-014516-r59usk02 2910 8 during during IN cord-014516-r59usk02 2910 9 therapy therapy NN cord-014516-r59usk02 2910 10 of of IN cord-014516-r59usk02 2910 11 group1 group1 NN cord-014516-r59usk02 2910 12 and and CC cord-014516-r59usk02 2910 13 group2 group2 NN cord-014516-r59usk02 2910 14 were be VBD cord-014516-r59usk02 2910 15 44.4 44.4 CD cord-014516-r59usk02 2910 16 and and CC cord-014516-r59usk02 2910 17 63.6 63.6 CD cord-014516-r59usk02 2910 18 % % NN cord-014516-r59usk02 2910 19 , , , cord-014516-r59usk02 2910 20 respectively respectively RB cord-014516-r59usk02 2910 21 . . . cord-014516-r59usk02 2911 1 There there EX cord-014516-r59usk02 2911 2 was be VBD cord-014516-r59usk02 2911 3 no no DT cord-014516-r59usk02 2911 4 significant significant JJ cord-014516-r59usk02 2911 5 difference difference NN cord-014516-r59usk02 2911 6 between between IN cord-014516-r59usk02 2911 7 the the DT cord-014516-r59usk02 2911 8 two two CD cord-014516-r59usk02 2911 9 groups group NNS cord-014516-r59usk02 2911 10 . . . cord-014516-r59usk02 2912 1 The the DT cord-014516-r59usk02 2912 2 survival survival NN cord-014516-r59usk02 2912 3 rates rate NNS cord-014516-r59usk02 2912 4 of of IN cord-014516-r59usk02 2912 5 dogs dog NNS cord-014516-r59usk02 2912 6 developing develop VBG cord-014516-r59usk02 2912 7 neurological neurological JJ cord-014516-r59usk02 2912 8 signs sign NNS cord-014516-r59usk02 2912 9 during during IN cord-014516-r59usk02 2912 10 therapy therapy NN cord-014516-r59usk02 2912 11 were be VBD cord-014516-r59usk02 2912 12 50 50 CD cord-014516-r59usk02 2912 13 % % NN cord-014516-r59usk02 2912 14 ( ( -LRB- cord-014516-r59usk02 2912 15 4/8 4/8 CD cord-014516-r59usk02 2912 16 ) ) -RRB- cord-014516-r59usk02 2912 17 in in IN cord-014516-r59usk02 2912 18 group group NN cord-014516-r59usk02 2912 19 1 1 CD cord-014516-r59usk02 2912 20 and and CC cord-014516-r59usk02 2912 21 4.8 4.8 CD cord-014516-r59usk02 2912 22 % % NN cord-014516-r59usk02 2912 23 ( ( -LRB- cord-014516-r59usk02 2912 24 1/22 1/22 CD cord-014516-r59usk02 2912 25 ) ) -RRB- cord-014516-r59usk02 2912 26 in in IN cord-014516-r59usk02 2912 27 group group NN cord-014516-r59usk02 2912 28 2 2 CD cord-014516-r59usk02 2912 29 , , , cord-014516-r59usk02 2912 30 respectively respectively RB cord-014516-r59usk02 2912 31 , , , cord-014516-r59usk02 2912 32 with with IN cord-014516-r59usk02 2912 33 a a DT cord-014516-r59usk02 2912 34 significant significant JJ cord-014516-r59usk02 2912 35 difference difference NN cord-014516-r59usk02 2912 36 between between IN cord-014516-r59usk02 2912 37 the the DT cord-014516-r59usk02 2912 38 two two CD cord-014516-r59usk02 2912 39 groups group NNS cord-014516-r59usk02 2912 40 . . . cord-014516-r59usk02 2913 1 In in IN cord-014516-r59usk02 2913 2 conclusion conclusion NN cord-014516-r59usk02 2913 3 , , , cord-014516-r59usk02 2913 4 additional additional JJ cord-014516-r59usk02 2913 5 administration administration NN cord-014516-r59usk02 2913 6 of of IN cord-014516-r59usk02 2913 7 porcine porcine JJ cord-014516-r59usk02 2913 8 anti anti JJ cord-014516-r59usk02 2913 9 - - JJ cord-014516-r59usk02 2913 10 CDV cdv JJ cord-014516-r59usk02 2913 11 antibody antibody NN cord-014516-r59usk02 2913 12 subunit subunit NNP cord-014516-r59usk02 2913 13 F(ab F(ab NNP cord-014516-r59usk02 2913 14 ' ' '' cord-014516-r59usk02 2913 15 ) ) -RRB- cord-014516-r59usk02 2913 16 2 2 CD cord-014516-r59usk02 2913 17 before before IN cord-014516-r59usk02 2913 18 developing develop VBG cord-014516-r59usk02 2913 19 of of IN cord-014516-r59usk02 2913 20 neurological neurological JJ cord-014516-r59usk02 2913 21 signs sign NNS cord-014516-r59usk02 2913 22 could could MD cord-014516-r59usk02 2913 23 decrease decrease VB cord-014516-r59usk02 2913 24 the the DT cord-014516-r59usk02 2913 25 mortality mortality NN cord-014516-r59usk02 2913 26 and and CC cord-014516-r59usk02 2913 27 furthermore furthermore RB cord-014516-r59usk02 2913 28 reduce reduce VB cord-014516-r59usk02 2913 29 the the DT cord-014516-r59usk02 2913 30 rate rate NN cord-014516-r59usk02 2913 31 of of IN cord-014516-r59usk02 2913 32 developing develop VBG cord-014516-r59usk02 2913 33 neurological neurological JJ cord-014516-r59usk02 2913 34 signs sign NNS cord-014516-r59usk02 2913 35 . . . cord-014516-r59usk02 2914 1 No no DT cord-014516-r59usk02 2914 2 conflicts conflict NNS cord-014516-r59usk02 2914 3 of of IN cord-014516-r59usk02 2914 4 interest interest NN cord-014516-r59usk02 2914 5 reported report VBN cord-014516-r59usk02 2914 6 . . .