id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288439-srzysoqy	Segal, Jonathan P.	Mechanisms underpinning the efficacy of faecal microbiota transplantation in treating gastrointestinal disease	2020-09-03		.txt	text/plain	6842	359	38	Faecal microbiota transplantation (FMT) is currently a recommended therapy for recurrent/ refractory Clostridioides difficile infection (CDI). Faecal microbiota transplantation (FMT) is currently a recommended therapy for recurrent/ refractory Clostridioides difficile infection (CDI). Rodent studies supported the concept that restoration of bacterial bile-metabolising capacity to the gut microbiota was protective against CDI, 39 prompting interest into whether this could also be a mechanism of efficacy of FMT. difficile; administration of an FXR agonist in a mouse model of colitis resulted in significantly reduced colonic inflammation and a more intact intestinal barrier, 44 while microbially mediated production of particular secondary bile acids exhibit anti-inflammatory effects on intestinal epithelial cells 45 and have been recently recognised as promoting generation of peripheral regulatory T cells. Restoration of short chain fatty acid and bile acid metabolism following fecal microbiota transplantation in patients with recurrent Clostridium difficile infection	./cache/cord-288439-srzysoqy.txt	./txt/cord-288439-srzysoqy.txt