id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-286912-cww4ha3j	Manolakis, Anastassios C	α2-Heremans-schmid glycoprotein (fetuin A) downregulation and its utility in inflammatory bowel disease	2017-01-21		.txt	text/plain	5348	272	48	METHODS: AHSG serum levels were determined in treatment-naïve newly-diagnosed patients, 96 with ulcerative colitis (UC), 84 with Crohn's disease (CD), 62 with diarrhea-predominant or mixed irritable bowel syndrome (IBS, Dand Mtypes) and 180 healthy controls (HC), by an enzyme linked immunosorbent assay (ELISA). Low levels of AHSG have been recorded in patients on hemodialysis, those with cirrhosis, hepatoma or rheumatoid arthritis (RA), an entity sharing common inflammatory pathways with IBD, and have been linked to vascular -excessive valvular and coronary artery calcification, ischemic events-and skeletal disorders -osteopenia [14, 17, 18] . In order to perform additional testing of the link between lower AHSG levels and complicated disease behavior, logistic regression was applied, while considering penetrating or stricturing CD, as dependent, and AHSG concentrations, in quartiles -lowest, low, high, highest -as independent variables. After multivariate analysis -also considering age, sex, activity, duration, smoking status-the inverse association between AHSG and need for anti-TNFα therapy or surgery remained statistically significant (partial correlation coefficients: -0.33 and -0.41, respectively -P < 0.05, in both cases).	./cache/cord-286912-cww4ha3j.txt	./txt/cord-286912-cww4ha3j.txt