id author title date pages extension mime words sentences flesch summary cache txt cord-285238-bpk3xl8x Dong, Xiuli Intestinal and Peripheral Fibrinogen-Like Protein 2 Expression in Inflammatory Bowel Disease 2013-11-28 .txt text/plain 3457 196 47 AIM: The purpose of this work was to investigate intestinal and peripheral expression of FGL2 in patients with inflammatory bowel disease (IBD), mainly ulcerative colitis (UC) and Crohn's disease (CD). Correlations of FGL2 expression with disease type, activity, and location, and with measured laboratory data, including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), were examined. However, our study demonstrated that intestinal and peripheral expression of FGL2 was significantly higher in UC and CD patients with active disease, and decreased in inactive disease. Reduced FGL2 expression in patients with inactive disease may be because successful treatment, including immune modifiers, anti-TNF-a therapy, and other anti-inflammatory treatment, made up for the deficiency of Treg cells, or reversed the deficiency to exert sufficient suppression against other subsets of T lymphocytes through multiple other suppression molecules. ./cache/cord-285238-bpk3xl8x.txt ./txt/cord-285238-bpk3xl8x.txt