id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-266392-bayabroa	Brenner, Erica J.	BENIGN EVOLUTION OF SARS-CoV2 INFECTIONS IN CHILDREN WITH INFLAMMATORY BOWEL DISEASE: RESULTS FROM TWO INTERNATIONAL DATABASES	2020-10-12		.txt	text/plain	1244	82	46	2 Since highest ACE2 expression is in the terminal ileum and colon, further upregulated during inflammation, and many COVID-19 patients experience gastrointestinal symptoms, longitudinal data are necessary determine whether inflammatory bowel diseases (IBD) patients are at risk for severe or complicated COVID-19. A recent analysis in IBD patients from the SECURE-IBD registry revealed older age, steroid medication and comorbidities as risk factors for severe evolution, while the same study showed that the 29 IBD patients less 20 years had only mild disease courses. Factors associated with hospitalization included comorbid conditions other than IBD (50% hospitalized vs 12% not; p value <0.01), moderate/severe IBD disease activity (64% vs 15%; p value <0.01 overall), gastrointestinal symptoms (71% vs 19%, p value <0.01), sulfasalazine/mesalamine use (57% vs 21%; p value 0.01), and steroid use (29% vs 8%, p value 0.03). The six-year-old colitis patient requiring ICU care in this series is in line with the recent reports of multi-systemic inflammatory (Kawasaki-like) syndrome temporarily related to SARS-CoV-2 infection in children.	./cache/cord-266392-bayabroa.txt	./txt/cord-266392-bayabroa.txt