id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-253001-xmcwuuk4	Papa, Alfredo	Epidemiology and the Impact of Therapies on the Outcome of COVID-19 in Patients With Inflammatory Bowel Disease	2020-08-19		.txt	text/plain	1451	79	49	A retrospective study from the United States including a large cohort of patients with IBD reported that the use of antitumor necrosis factor (TNF)-a agents or thiopurines was not associated with an increased risk of developing COVID-19 (9) . In the Surveillance Epidemiology of Coronavirus Under Research Exclusion-IBD database, we found evidence of greater prevalence of milder COVID-19 cases in patients treated with anti-TNF-a than that in patients undergoing steroid treatments (3) . Further support to this theory comes from the results of the Italian Group for the Study of Inflammatory Bowel Disease study, which reported a 60% reduction in mortality among patients receiving anti-TNF-a antibodies (although not statistically significant); however, corticosteroid use was associated, with a trend toward statistical significance, with COVID-19-related pneumonia (P 5 0.05) and death (P 5 0.064) (4). Furthermore, anti-TNF-a agents could achieve effective control of inflammatory mediators, which makeup the "cytokine storm" that occurs in severe COVID-19-related pneumonia, thereby mitigating the course of the disease.	./cache/cord-253001-xmcwuuk4.txt	./txt/cord-253001-xmcwuuk4.txt