id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017342-qsfykh1k	Nedelsky, Natalia B.	Inflammatory Bowel Disease at the Intersection of Autophagy and Immunity: Insights from Human Genetics	2013-06-21		.txt	text/plain	8796	424	36	Although historically considered to be a relatively nonselective process of degradation of cytosolic contents, autophagy has recently been revealed to have several selective and immune-specific functions that are relevant to the maintenance of intestinal homeostasis, including xenophagy, mitophagy, antigen presentation, secretion, and inflammasome regulation. We summarize the basic molecular events underlying general and selective autophagy and present evidence suggesting possible pathogenic mechanisms revealed by studies of IBD-associated risk alleles of ATG16L1 and IRGM. As mentioned above, autophagy has been implicated in several immune-related processes that infl uence IBD pathogenesis, including xenophagy, mitophagy, antigen presentation, secretion and vesicular traffi cking, and cytokine-based regulation of infl ammasome activity. In epithelial cells, bacteria become ubiquitinated and targeted for autophagic degradation in a process that requires the CD-associated genes ATG16L1 and IRGM appears to have different effects on these functions depending on the cell type examined [ 42 , 67 ] .	./cache/cord-017342-qsfykh1k.txt	./txt/cord-017342-qsfykh1k.txt