id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005789-jngjusk2	Selden, Richard F	Regulation of human insulin gene expression in transgenic mice	1986		.txt	text/plain	3092	149	48	We report here that the human insulin gene is expressed in a tissue-specific manner in the islets of these transgenic mice, and that serum human insulin levels are properly regulated by glucose, amino acids and tolbutamide, an oral hypoglycaemic agent. We report here that the human insulin gene is expressed in a tissue-specific manner in the islets of these transgenic mice, and that serum human insulin levels are properly regulated by glucose, amino acids and tolbutamide, an oral hypoglycaemic agent. The tissue specificity of human insulin gene expression in these transgenic mice was examined by both RNA analyses and pancreatic islet function studies. Glucose and human C-peptide levels in the transgenic mice were studied under a variety of physiological conditions to determine whether normal glucose homeostasis was being preserved and whether expression of the human insulin gene was being regulated appropriately in these mice.	./cache/cord-005789-jngjusk2.txt	./txt/cord-005789-jngjusk2.txt