id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-292645-5nplyyai	Hawkinson, Dana	Novel Antiviral Agents for Respiratory Viral Infection in Immunocompromised Adults	2013-10-22		.txt	text/plain	3983	212	37	In the immunocompromised populations, particularly those undergoing chemotherapy for malignancy and solid organ and hematopoeitic stem cell transplant patients, viral respiratory infections can cause high rates of morbidity and mortality. Several case reports of pediatric immunocompromised hosts, including those with HSCT, leukemia, and liver transplantation, appear in the literature, predominantly with oseltamivir-resistant pandemic influenza H1N1 viral isolates. Despite limited data on its efficacy in clearing RSV infection in solid organ transplant (SOT), ribavirin, especially in the aerosolized form, has additionally been evaluated in conjunction with other therapies, including steroids, IVIG, and palivizumab (see below), and remains a standard part of many local treatment protocols. The current antiviral armamentarium against respiratory viral infections aside from influenza therapies is limited, resulting in few options to impact the associated morbidity and mortality from these illnesses in immunocompromised hosts. Respiratory failure caused by 2009 novel influenza A/H1N1 in a hematopoietic stem-cell transplant recipient: detection of extrapulmonary H1N1 RNA and use of intravenous peramivir	./cache/cord-292645-5nplyyai.txt	./txt/cord-292645-5nplyyai.txt