id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005448-5fznfp5p	Holtan, S G	CD34(+) cell dose and establishment of full donor chimerism at day +100 are important factors for survival with reduced-intensity conditioning with fludarabine and melphalan before allogeneic hematopoietic SCT for hematologic malignancies	2010-03-08		.txt	text/plain	2589	120	39	title: CD34(+) cell dose and establishment of full donor chimerism at day +100 are important factors for survival with reduced-intensity conditioning with fludarabine and melphalan before allogeneic hematopoietic SCT for hematologic malignancies The combination of fludarabine and melphalan as a reduced-intensity conditioning (RIC) regimen extends allogeneic hematopoietic SCT (HSCT) as a therapeutic option for elderly or frail patients with relapsed, refractory or other high-risk hematologic malignancies. Factors analyzed for association with survival included demographic and disease factors (age at transplant, sex, lymphoid vs myeloid disease, karyotype and blast percentage in those with MDS and leukemia, disease status at transplant, previous HSCT, and previous chemotherapy for solid tumors), donor/graft factors (CD34 þ cell dose, graft source, related vs unrelated graft, degree of HLA match, CMV serostatus and ABO match), and post transplant factors (time to neutrophil, lymphocyte and platelet engraftment, day þ 100 chimerism status, development of and severity of acute GVHD, development of and severity of chronic GVHD).	./cache/cord-005448-5fznfp5p.txt	./txt/cord-005448-5fznfp5p.txt