Summary of your 'study carrel' ============================== This is a summary of your Distant Reader 'study carrel'. The Distant Reader harvested & cached your content into a collection/corpus. It then applied sets of natural language processing and text mining against the collection. The results of this process was reduced to a database file -- a 'study carrel'. The study carrel can then be queried, thus bringing light specific characteristics for your collection. These characteristics can help you summarize the collection as well as enumerate things you might want to investigate more closely. This report is a terse narrative report, and when processing is complete you will be linked to a more complete narrative report. Eric Lease Morgan Number of items in the collection; 'How big is my corpus?' ---------------------------------------------------------- 82 Average length of all items measured in words; "More or less, how big is each item?" ------------------------------------------------------------------------------------ 1597 Average readability score of all items (0 = difficult; 100 = easy) ------------------------------------------------------------------ 49 Top 50 statistically significant keywords; "What is my collection about?" ------------------------------------------------------------------------- 79 HRV 16 PCR 15 RSV 12 infection 11 respiratory 9 COPD 8 virus 8 study 8 patient 8 cell 8 airway 8 RNA 7 result 7 method 7 increase 7 Nil 7 Interest 7 FEV 7 ASM 5 child 5 asthma 3 outbreak 3 IFN 2 viral 2 sequence 2 rhinovirus 2 human 2 heart 2 exacerbation 2 HRV-2 2 HRSV 2 HMPV 2 Fig 2 ELISA 2 ASC 2 ARI 1 year 1 vp2 1 visit 1 table 1 subject 1 sop 1 sirt1 1 prevalence 1 polymerase 1 lbw 1 lambda 1 inflammation 1 illness 1 household Top 50 lemmatized nouns; "What is discussed?" --------------------------------------------- 4906 % 3633 infection 3193 virus 2948 patient 2841 study 2784 asthma 2562 child 2107 cell 1612 rhinovirus 1434 year 1326 result 1296 p 1256 disease 1242 age 1149 group 1086 method 1041 airway 969 lung 940 exacerbation 934 symptom 933 n 903 sample 892 time 867 subject 857 response 850 day 798 detection 794 sequence 782 datum 781 treatment 768 case 755 analysis 741 effect 732 risk 720 rate 694 adult 691 conclusion 687 illness 675 level 656 control 653 infant 619 expression 615 tract 595 number 595 difference 594 factor 564 test 556 culture 547 influenza 544 strain Top 50 proper nouns; "What are the names of persons or places?" -------------------------------------------------------------- 4037 HRV 899 al 829 PCR 786 RSV 731 . 698 COPD 694 et 689 RNA 667 C 530 A 496 signifi 312 ed 297 B 292 fi 285 CF 282 IFN 252 Confl 249 Fig 247 FEV 235 fl 234 RT 226 infl 216 CI 206 identifi 205 ARI 196 ± 193 Hospital 191 ASM 186 Health 179 Methods 176 Rhinovirus 169 Table 167 M 165 defi 161 DI 154 IgA 153 D 152 S 150 Australia 148 L 147 Nil 145 Asthma 138 AR 133 NIV 132 ned 131 III 131 ELISA 127 Wa 126 ICC 125 uenza Top 50 personal pronouns nouns; "To whom are things referred?" ------------------------------------------------------------- 1184 we 769 it 317 they 105 them 84 i 66 she 28 us 20 themselves 19 one 16 itself 12 you 5 he 2 isg56-mrnas 1 pteronyssinus 1 ours 1 mg 1 interferon--7 1 herself 1 her 1 em Top 50 lemmatized verbs; "What do things do?" --------------------------------------------- 19944 be 3764 have 2241 use 1327 associate 1213 increase 1014 show 972 compare 945 include 877 detect 685 induce 670 report 653 reduce 642 perform 624 do 612 find 601 base 599 follow 592 determine 514 identify 487 suggest 484 aim 432 develop 427 cause 427 assess 400 require 400 collect 393 measure 381 relate 375 occur 341 wheeze 334 describe 330 infect 317 obtain 312 hospitalize 306 investigate 298 provide 297 observe 286 support 284 treat 284 test 284 examine 271 result 266 involve 263 indicate 262 present 262 predict 251 know 246 mean 244 consider 242 improve Top 50 lemmatized adjectives and adverbs; "How are things described?" --------------------------------------------------------------------- 3223 respiratory 2124 not 1809 viral 1434 human 1403 - 1126 clinical 1054 high 1027 low 1025 more 987 acute 830 also 820 other 816 positive 727 common 639 most 602 however 553 severe 507 only 493 non 482 different 469 such 463 well 448 pulmonary 405 new 399 molecular 392 early 391 young 367 epithelial 355 respectively 355 chronic 348 specific 341 mean 340 large 335 similar 335 further 334 healthy 334 antiviral 332 immune 331 single 328 syncytial 322 less 314 cantly 312 first 311 important 310 significant 310 long 307 major 301 as 293 likely 291 small Top 50 lemmatized superlative adjectives; "How are things described to the extreme?" ------------------------------------------------------------------------- 132 most 111 least 89 good 65 high 52 Most 32 low 28 common 25 large 16 strong 12 great 11 near 7 short 6 early 5 close 3 young 2 long 1 ~15 1 weak 1 warm 1 southernmost 1 secondholi 1 old 1 moresevere 1 mild 1 late 1 laCi 1 holy 1 healthy 1 fast 1 fair 1 clear 1 bad 1 -t 1 -particulates 1 -NH 1 -D 1 -A1b Top 50 lemmatized superlative adverbs; "How do things do to the extreme?" ------------------------------------------------------------------------ 507 most 81 least 5 well 1 ® 1 highest 1 early Top 50 Internet domains; "What Webbed places are alluded to in this corpus?" ---------------------------------------------------------------------------- 16 doi.org 3 blast.ncbi.nlm.nih.gov 2 www.ncbi.nlm.nih.gov 2 www.cdc.gov 1 www.tutiempo.net 1 www.r-project.org 1 www.picornastudygroup.com 1 www.pasteur-international.org 1 www.megasoft 1 www.international-rhinovirus-consortium.org 1 www.graphpad.com 1 www.dchip.org 1 sourceforge.net 1 sfbay.craigslist.org 1 physionet.org 1 paup.csit.fsu.edu 1 gap.stat 1 frontend 1 evolve.zoo.ox.ac.uk 1 eprevention.gr 1 dx.doi.org 1 clinicaltrials.gov 1 apps.who.int Top 50 URLs; "What is hyperlinked from this corpus?" ---------------------------------------------------- 12 http://doi.org/10.1101/2020.07.05.20146571 2 http://www.cdc.gov/ncidod/sars 2 http://doi.org/10.1101/2020.07.30.20165118 2 http://blast.ncbi.nlm.nih.gov/ 1 http://www.tutiempo.net/en/Climate/Shantou/2011/ 1 http://www.r-project.org 1 http://www.picornastudygroup.com/ 1 http://www.pasteur-international.org/ip/easysite/ 1 http://www.ncbi.nlm.nih.gov/geo/ 1 http://www.ncbi.nlm.nih.gov 1 http://www.megasoft 1 http://www.international-rhinovirus-consortium.org/ 1 http://www.graphpad.com/quickcalcs/ 1 http://www.dchip.org 1 http://sourceforge.net/ 1 http://sfbay.craigslist.org/ 1 http://physionet.org 1 http://paup.csit.fsu.edu 1 http://gap.stat 1 http://frontend 1 http://evolve.zoo.ox.ac.uk/software.html 1 http://eprevention.gr 1 http://dx.doi.org/10.1128/ 1 http://doi.org/10.1017/S0950268819001754 1 http://doi.org/10.1016/j.jinf.2017.10.012 1 http://clinicaltrials.gov/show/ 1 http://blast.ncbi.nlm.nih.gov/Blast 1 http://apps.who.int/globalatlas/dataQuery/default.asp Top 50 email addresses; "Who are you gonna call?" ------------------------------------------------- Top 50 positive assertions; "What sentences are in the shape of noun-verb-noun?" ------------------------------------------------------------------------------- 15 % were male 14 cells were then 14 children requiring emergency 13 studies have not 12 rhinoviruses are common 10 disease is not 10 infections were more 10 samples were positive 8 hrv is more 8 patients is important 8 patients were female 8 patients were male 8 viruses are commonly 7 % had hrvc 7 % had pet 7 % were hrv 7 airway including activation 7 airway is unclear 7 airways using lpc 7 asthma had signifi 7 asthma related quality 7 asthma require further 7 cells were similar 7 child required invasive 7 children are also 7 children are most 7 children had recurrent 7 children have previously 7 children were initially 7 day following allergen 7 day following challenge 7 group had lower 7 group was −0.58 7 groups were similar 7 infection is usually 7 infections has advantages 7 lung did not 7 lung suggest common 7 methods induced sputum 7 patient required surgery 7 patients following resection 7 patients had at 7 patients had bronchoscopy 7 patients had hrct 7 patients had inhalers 7 patients had raynauds 7 patients had resolution 7 patients reported reduction 7 patients required icc 7 patients were identifi Top 50 negative assertions; "What sentences are in the shape of noun-verb-no|not-noun?" --------------------------------------------------------------------------------------- 7 patient had no errors 7 studies have not conclusively 7 subjects is not due 4 disease is not exclusively 2 % were no longer 2 infection are not available 1 asthma are not available 1 asthma are not clear 1 asthma are not well 1 asthma is not fully 1 asthma is not inappropriately 1 asthma were not as 1 cells do not always 1 children is not clear 1 children were not well 1 detection is not random 1 disease are not subject 1 disease is not comprehensive 1 disease is not only 1 disease is not well 1 diseases are not well 1 exacerbation is not yet 1 group were not significant 1 groups had no significant 1 groups showed no statistically 1 groups was not remarkably 1 groups was not significant 1 groups was not significantly 1 hrv are not well 1 hrv is not sufficient 1 infection are not completely 1 infection is not clear 1 infection is not cytopathic 1 infection is not life 1 infections has not only 1 method was not exclusively 1 methods are not available 1 methods are not practical 1 methods have not yet 1 patient were not present 1 patients are not well 1 patients is not yet 1 patients were not only 1 patients were not significantly 1 response are not yet 1 responses are not well 1 results have not yet 1 results showed no serious 1 results was no more 1 results were not surprising A rudimentary bibliography -------------------------- id = cord-022084-hap7flng author = ARRUDA, EURICO title = Respiratory Tract Viral Infections date = 2009-05-15 keywords = HMPV; HRV; PCR; RNA; RSV; SARS; child; infection; respiratory; virus summary = The Centers for Disease Control and Prevention (CDC) recommends the immunization of persons aged 50 years and older; residents of nursing homes; children and adults with chronic cardiovascular or pulmonary disease, including asthma; persons chronically ill with diabetes mellitus, renal dysfunction, or hemoglobinopathies; immunosuppressed patients including those with HIV infection; children and adolescents on chronic aspirin therapy who may develop postinfluenza Reye'' s syndrome; women who will be pregnant during the influenza season; children aged 6 to 23 months; those who can transmit influenza to persons at high risk, such as health-care workers and household contacts of those at high risk including children 0 to 23 months of age; crew members of cruise ships; providers of essential services; and unimmunized travelers to areas where influenza may be circulating, including the tropics, the southern hemisphere between April and September, and those traveling in large organized tourist groups. doi = 10.1016/b978-0-443-06668-9.50064-8 id = cord-346253-0mnsm6s4 author = Ahanchian, Hamid title = Respiratory viral infections in children with asthma: do they matter and can we prevent them? date = 2012-09-13 keywords = HRV; RSV; asthma; infection; respiratory summary = HRV are the most common viral agents [33] ; Other respiratory tract viruses detected in children with an asthma exacerbation include RSV, influenza, coronavirus, hMPV, parainfluenza virus, adenovirus, and bocavirus [34] [35] [36] . Beside importance for bone health, vitamin D plays an important role in adequate function of both the innate and adaptive immune systems including development of dendritic cells and regulatory T lymphocytes [151, 152] production of antimicrobial proteins by airway epithelium [153] , modifying the effect of intestinal flora on inflammatory disorders [107] , and modulation of the inflammatory response to viral infections [154] . In a recent study of 48 children from five to 18 years of age, with newly diagnosed asthma, vitamin D supplementation during the northern hemisphere winter months (September to July) prevented declining serum concentrations of 25(OH) D and reduced the risk of asthma exacerbation triggered by acute respiratory tract infections [161] . doi = 10.1186/1471-2431-12-147 id = cord-290773-kgb8r561 author = Ahn, Jong Gyun title = Clinical characteristics and cytokine profiles of children with acute lower respiratory tract infections caused by human rhinovirus date = 2018-07-03 keywords = HRV summary = doi = 10.1371/journal.pone.0198624 id = cord-280391-5kiu2pb6 author = Akinloye, Oluwabukola M. title = Specific Viruses Detected in Nigerian Children in Association with Acute Respiratory Disease date = 2011-10-11 keywords = HRV; virus summary = doi = 10.1155/2011/690286 id = cord-333261-knj2rrut author = Albright, Catherine J. title = An exercise in molecular epidemiology: Human rhinovirus prevalence and genetics date = 2011-11-11 keywords = HRV; PCR; RNA summary = doi = 10.1002/bmb.20530 id = cord-016783-8x05oh5q author = Arruda, L. Karla title = Early Interventions in Allergic Diseases date = 2010 keywords = HRV; Prevention; RSV; asthma; child summary = doi = 10.1007/978-4-431-99362-9_23 id = cord-309497-3v0asfa7 author = Asner, Sandra title = Respiratory viral infections in institutions from late stage of the first and second waves of pandemic influenza A (H1N1) 2009, Ontario, Canada date = 2012-02-21 keywords = HRV; outbreak summary = doi = 10.1111/j.1750-2659.2012.00336.x id = cord-289358-4abypk6o author = Asner, Sandra A. title = Clinical severity of rhinovirus/enterovirus compared to other respiratory viruses in children date = 2014-05-07 keywords = ENT; HRV; RSV summary = doi = 10.1111/irv.12255 id = cord-009877-3cyz6o9c author = Barclay, Wendy S. title = Evaluation of an enzyme‐linked immunosorbent assay that measures rhinovirus‐specific antibodies in human sera and nasal secretions date = 2005-12-07 keywords = ELISA; HRV-2 summary = doi = 10.1002/jmv.1890250411 id = cord-354011-v9t2b2ca author = Benkouiten, Samir title = Circulation of Respiratory Viruses Among Pilgrims During the 2012 Hajj Pilgrimage date = 2013-10-01 keywords = HRV; Hajj; KSA summary = doi = 10.1093/cid/cit446 id = cord-259997-8f8di4eu author = Botti, Chiara title = Characterization of respiratory infection viruses in hospitalized children from Naples province in Southern Italy date = 2018-04-13 keywords = HRV; Naples; respiratory summary = doi = 10.3892/etm.2018.6061 id = cord-284875-hsa2r7ns author = Bourdillon, N. title = Effects of COVID-19 lockdown on heart rate variability date = 2020-08-01 keywords = CFN; HRV summary = doi = 10.1101/2020.07.30.20165118 id = cord-287063-kheek4lx author = Carroll, Kecia N. title = Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections date = 2012-02-14 keywords = ARI; HRV; RSV summary = doi = 10.1016/j.jaci.2012.01.045 id = cord-010160-wk8k2igu author = Chandrasekaran, Alamelu title = Broad reactivity of the Luminex xTAG Respiratory Virus Panel (RVP) assay for the detection of human rhinoviruses date = 2012-01-04 keywords = HRV summary = doi = 10.1016/j.jcv.2011.12.006 id = cord-316245-n6tmn4ph author = Cui, Binglin title = Viral aetiology of acute respiratory infections among children and associated meteorological factors in southern China date = 2015-03-13 keywords = HRV; PIV3; virus summary = doi = 10.1186/s12879-015-0863-6 id = cord-316319-m6uha1qn author = Daleno, Cristina title = Phylogenetic Analysis of Human Rhinovirus Isolates Collected from Otherwise Healthy Children with Community-Acquired Pneumonia during Five Successive Years date = 2013-11-19 keywords = HRV summary = doi = 10.1371/journal.pone.0080614 id = cord-009922-t1hoox6e author = Dearden, C. J. title = Direct detection of rhinoviruses by an enzyme‐linked immunosorbent assay date = 2005-12-07 keywords = ELISA; HRV; HRV-2 summary = This paper describes the first enzyme‐linked immunosorbent assay for the detection of rhinovirus antigens in clinical specimens (nasal washings), either directly or following overnight cell culture amplification. Secondly, a direct ELISA system was developed in which the nasal washings or control antigen (uninfected tissue culture fluid) were added directly to each of a set of duplicate ELISA plate wells coated with either pre-or postchallenge rabbit anti HRV-EL hyperimmune serum. Figure 2 shows the results obtained with nasal washings, collected from three volunteers on consecutive days following HKV-EL or saline challenge, tested in both the cell-culture-amplified (CCA)-ELISA and direct ELISA systems. Although we would like to emphasise that our data are preliminary, both the direct and CCA-ELISAs gave a good correlation with virus isolation when used to detect rhinovirus antigens in nasal washings (obtained from 18 volunteers challenged with either HRV-EL or saline). doi = 10.1002/jmv.1890230211 id = cord-023713-daz2vokz author = Devereux, Graham title = Epidemiology of Asthma and Allergic Airway Diseases date = 2013-09-06 keywords = HRV; Health; States; United; asthma; child; prevalence; study; year summary = A systematic review and metaanalysis of the longitudinal studies relating maternal vitamin D status during pregnancy to childhood outcomes concluded that high maternal dietary vitamin D intake is associated with a reduced risk of children wheezing up to the age of 5 years (OR = 0.56; 95% CI, 0.42 to 0.73). The Dutch Prevention and Incidence of Asthma and Mite allergy (PIAMA) birth cohort study related symptom data prospectively collected annually from 3863 children up to the age of 8 years to land-use regression estimates of individual NO 2 , PM 2.5 , and soot exposures at their birth addresses. 327 A systematic review and meta-analysis of prospective birth cohort studies evaluating the effects of allergen (i.e., HDM or dietary) avoidance during pregnancy concluded that early-life allergen avoidance in isolation does not reduce the likelihood of asthma in children at age 5 years (OR = 1.22; 95% CI, 0.83 to 1.78). doi = 10.1016/b978-0-323-08593-9.00049-8 id = cord-268093-ta6k0uyz author = Etemadi, Mohammad Reza title = Biodiversity and clinico-demographic characteristics of human rhinoviruses from hospitalized children with acute lower respiratory tract infections in Malaysia() date = 2013-08-07 keywords = HRV; RSV summary = The presence of the new HRV-C strain in severe respiratory disease has further instilled research interest in the clinical impact, molecular biology and epidemiology of HRVs. As research of HRV is limited [8] , especially in Asian developing countries, this study aims to examine the molecular epidemiology, the demographic characteristics and clinical features including the newly discovered HRV-C species, among hospitalized children less than 5 years of age with ALRTI in Malaysia. HRV infected patients were admitted earlier compared to RSV and influenza; children with HRV presented to the hospital after a mean duration of 1.9 days (ranged 1-9 days) as compared with HRV (4.0 days, p = <0.001) and IFV-A (4.8 days, p = 0.002). Our study revealed that HRV infected children were hospitalized earlier in the course of their disease and were less febrile on presentation as compared to RSV and IFV-A infections. doi = 10.1016/j.jcv.2013.05.017 id = cord-281162-2pu7x5rj author = Etemadi, Mohammad Reza title = Diversity of respiratory viruses detected among hospitalized children with acute lower respiratory tract infections at Hospital Serdang, Malaysia date = 2019-03-22 keywords = HMPV; HRV; PCR; RSV summary = doi = 10.1016/j.jviromet.2019.03.013 id = cord-328795-rs1sd42z author = Falsey, Ann R. title = Rhinoviruses date = 2016-10-24 keywords = HRV; PCR; Turner; infection summary = doi = 10.1016/b978-0-12-803678-5.00386-6 id = cord-314841-b5l6epy3 author = Falsey, Ann Regina title = Respiratory viral infections date = 2019-08-15 keywords = H1N1; HRV; RSV; infection; respiratory summary = doi = 10.1016/b978-0-12-801496-7.00009-5 id = cord-000483-zgapjjjw author = Faux, Cassandra E. title = Usefulness of Published PCR Primers in Detecting Human Rhinovirus Infection date = 2011-02-17 keywords = HRV; PCR summary = doi = 10.3201/eid1702.101123 id = cord-225218-x32a4sp3 author = Filntisis, Panagiotis P. title = Identifying differences in physical activity and autonomic function patterns between psychotic patients and controls over a long period of continuous monitoring using wearable sensors date = 2020-10-30 keywords = HRV; feature; patient summary = doi = nan id = cord-004749-wyzb8v4a author = Forsyth, M. title = Rhinovirus detection using probes from the 5′ and 3′ end of the genome date = 1989 keywords = HRV-14 summary = doi = 10.1007/bf01313878 id = cord-327610-cm3vkpcn author = Fukuda, Yosuke title = Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach date = 2020-08-13 keywords = Asthma; HRV; airway; cell; exacerbation; inflammation; sirt1 summary = doi = 10.3390/jcm9082623 id = cord-327344-8gi1wb76 author = Gambarino, Stefano title = Development of a RT Real-Time PCR for the Detection and Quantification of Human Rhinoviruses date = 2009-03-17 keywords = HRV; PCR summary = This article describes the development and optimization of a reverse transcription (RT) real-time PCR assay for quantification of HRV RNA in clinical samples. Clinical specimens originated from the Virology Unit of the Fig. 1 Standard curve (from 10 2 to 10 5 copies/reaction) and dynamic range (from 10 7 to 10 1 copies/reaction) of the real-time RT-PCR developed in this study Azienda Ospedaliero-Universitaria San Giovanni Battista, Turin, and included 110 bronchoalveolar lavages (BAL) obtained from 84 patients (M/F, 57/27; mean age, 57.8 years; range, . The performance of the RT real-time PCR developed in this study was examined over different concentrations of HRV RNA and it was found to be very sensitive with a minimum cut-off for detection of 10 0 copy/reaction and was linear up to 10 1 copies. In conclusion, the RT real-time PCR assay developed in this study could represent a useful tool for diagnosing HRV infections, quantifying the viral load and could be applicable for routine diagnostic workup of upper as well as lower respiratory tract diseases. doi = 10.1007/s12033-009-9164-x id = cord-317198-mean7sj9 author = Giamberardin, Heloisa I.G. title = Clinical and epidemiological features of respiratory virus infections in preschool children over two consecutive influenza seasons in southern Brazil date = 2016-02-09 keywords = HRV; infection; virus summary = doi = 10.1002/jmv.24477 id = cord-310171-1fmsxx2s author = Goffard, Anne title = Virus and cystic fibrosis: Rhinoviruses are associated with exacerbations in adult patients() date = 2014-02-25 keywords = HRV; virus summary = doi = 10.1016/j.jcv.2014.02.005 id = cord-307990-skrye40w author = Hai, Le Thanh title = Fatal Respiratory Infections Associated with Rhinovirus Outbreak, Vietnam date = 2012-11-17 keywords = HRV; outbreak summary = doi = 10.3201/eid1811.120607 id = cord-004694-43yvs52a author = Han, Tae-Hee title = Detection of human rhinovirus C in children with acute lower respiratory tract infections in South Korea date = 2009-05-05 keywords = HRV summary = doi = 10.1007/s00705-009-0383-z id = cord-000082-jy7j8sh0 author = Huang, Ting title = Evidence of Recombination and Genetic Diversity in Human Rhinoviruses in Children with Acute Respiratory Infection date = 2009-07-27 keywords = HRV; table; vp2 summary = doi = 10.1371/journal.pone.0006355 id = cord-316932-fia1w9jt author = Ireland, D. C. title = Improved detection of rhinoviruses in nasal and throat swabs by seminested RT‐PCR date = 2005-12-07 keywords = HRV; PCR summary = doi = 10.1002/jmv.1890400204 id = cord-272125-dez1nzg4 author = Jartti, T. title = Allergic sensitization is associated with rhinovirus‐, but not other virus‐, induced wheezing in children date = 2010-10-26 keywords = HRV; RSV; child summary = A specific immunoglobulin E (IgE) sensitization for common food and aeroallergens and other atopy‐related variables including total IgE, blood and nasal eosinophils, exhaled nitric oxide, eczema and atopic eczema, parental allergy and asthma, number of wheezing episodes, positive asthma predictive index or asthma and use of inhaled corticosteroid were correlated with specific viral etiology. The number of sensitizations was particularly associated with sole rhinovirus etiology (odds ratio 4.59; 95% confidence interval 1.78, 11.8; adjusted to age and sex), followed by aeroallergen sensitization (respectively; 4.18; 2.00, 8.72), total IgE level (2.06; 1.32, 3.21), food allergen sensitization (2.02; 1.08, 3.78), and nasal eosinophil count (1.52; 1.08, 2.13). Log 10 Number of sensitizations were particularly associated with sole HRV etiology (odds ratio 4.59; adjusted to age and sex), followed by aeroallergen sensitization (respectively, 4.18), total IgE level (2.06), food allergen sensitization (2.02), and nasal eosinophil count (1.52) (p < 0.05 for all, Fig. 1b , Table S2 ). doi = 10.1111/j.1399-3038.2010.01059.x id = cord-291486-5h96msv1 author = Kistler, Amy title = Pan-Viral Screening of Respiratory Tract Infections in Adults With and Without Asthma Reveals Unexpected Human Coronavirus and Human Rhinovirus Diversity date = 2007-09-15 keywords = HRV; HRV'X; PCR; Virochip summary = doi = 10.1086/520816 id = cord-252347-vnn4135b author = Lee, Wai-Ming title = A Diverse Group of Previously Unrecognized Human Rhinoviruses Are Common Causes of Respiratory Illnesses in Infants date = 2007-10-03 keywords = HRV; P1-P2; PCR; sequence summary = doi = 10.1371/journal.pone.0000966 id = cord-258336-zs04l3s0 author = Leotte, Jaqueline title = Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years date = 2017-06-30 keywords = HRV; infection; respiratory summary = doi = 10.1016/j.jped.2016.07.004 id = cord-299672-dq1y1gkc author = Leung, Ting Fan title = Multiplex Molecular Detection of Respiratory Pathogens in Children With Asthma Exacerbation date = 2010-02-28 keywords = HRV; PCR; asthma summary = doi = 10.1378/chest.09-1250 id = cord-321989-1enjopig author = Li, Yanpeng title = Metagenomic analysis identified co-infection with human rhinovirus C and bocavirus 1 in an adult suffering from severe pneumonia date = 2017-10-31 keywords = HRV summary = doi = 10.1016/j.jinf.2017.10.012 id = cord-103367-fxvvndic author = Liu, N. title = Machine learning dimensionality reduction for heart rate n-variability (HRnV) based risk stratification of chest pain patients in the emergency department date = 2020-07-06 keywords = HRV; MACE; heart summary = doi = 10.1101/2020.07.05.20146571 id = cord-291238-myjyw8ei author = Longtin, Jean title = Rhinovirus Outbreaks in Long-term Care Facilities, Ontario, Canada date = 2010-09-17 keywords = HRV; outbreak summary = Although the most commonly identifi ed viruses have been infl uenza virus and respiratory syncytial virus (RSV) (1), human rhinovirus (HRV) is being increasingly associated with severe respiratory disease and outbreaks in these facilities (2) (3) (4) (5) (6) . As a result, the number of outbreaks caused by HRV in long-term care facilities, and the associated illness and death, may be substantially underestimated. During the surveillance period, 297 respiratory disease outbreaks in long-term care facilities were reported to the Ontario Public Health Laboratory; we received samples from 269 facilities (Table 1) . We cautiously assume that HRV was the causative organism for 174 (59%) of the 297 respiratory outbreaks in long-term care facilities in Ontario during the surveillance period. Neighbor-joining phylogenetic tree of human rhinoviruses (HRV) isolated from 4 respiratory disease outbreaks with associated deaths in long-term care facilities, Ontario, Canada. doi = 10.3201/eid1609.100476 id = cord-016499-5iqpl23p author = Mackay, Ian M. title = Rhinoviruses date = 2014-02-27 keywords = ARI; HRSV; HRV; IFN; PCR; RNA; human; infection; respiratory; rhinovirus; viral; virus summary = A convenience population of 15 healthy children (1-9 years old) without asthma were followed during at least three seasons, and picornaviruses were detected in 5 % of 740 specimens (21 % of infections) not associated with symptoms, The impact of HRV typing and of sampling based only on symptoms. Clinical features and complete genome characterization of a distinct human rhinovirus genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children Comparison of results of detection of rhinovirus by PCR and viral culture in human nasal wash specimens from subjects with and without clinical symptoms of respiratory illness Detection of human rhinovirus C viral genome in blood among children with severe respiratory infections in the Philippines doi = 10.1007/978-1-4899-7448-8_29 id = cord-351571-gwtkrt5u author = Mackay, Ian M. title = Community-Wide, Contemporaneous Circulation of a Broad Spectrum of Human Rhinoviruses in Healthy Australian Preschool-Aged Children During a 12-Month Period date = 2013-05-01 keywords = HRV; virus summary = doi = 10.1093/infdis/jis476 id = cord-342993-deuytbml author = Maffey, Alberto F. title = Viruses and atypical bacteria associated with asthma exacerbations in hospitalized children date = 2010-05-06 keywords = HRSV; HRV; respiratory summary = doi = 10.1002/ppul.21236 id = cord-307602-2cmgu7rf author = McErlean, P. title = Characterisation of a newly identified human rhinovirus, HRV-QPM, discovered in infants with bronchiolitis date = 2007-05-07 keywords = HRV; PCR; QPM summary = doi = 10.1016/j.jcv.2007.03.012 id = cord-325137-6c6er06a author = Moser, Lindsey A. title = A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses date = 2016-06-07 keywords = CPE; Fig; HRV-16; PCR; RNA; sop summary = doi = 10.1128/msystems.00039-15 id = cord-001601-tsuz3j40 author = Ngan, Luong Thi My title = Antiviral Activity and Possible Mechanism of Action of Constituents Identified in Paeonia lactiflora Root toward Human Rhinoviruses date = 2015-04-10 keywords = HRV; HRV-4; MRC5; PGG summary = An assessment was made of the antiviral activities and mechanisms of action of paeonol (PA) and 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG) from Paeonia lactiflora root toward HRV-2 and HRV-4 in MRC5 cells using a tetrazolium method and real-time quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay. These findings suggest that PGG and PA may block or reduce the entry of the viruses into the cells to protect the cells from the virus destruction and abate virus replication, which may play an important role in interfering with expressions of rhinovirus receptors (intercellular adhesion molecule-1 and low-density lipoprotein receptor), inflammatory cytokines (interleukin (IL)-6, IL-8, tumor necrosis factor, interferon beta, and IL-1β), and Toll-like receptor, which resulted in diminishing symptoms induced by HRV. In the presence of 100 μg/mL PA or 20 μg/mL PGG in MRC5 cell cultures infected with HRV-2, the RNA replication levels were reduced by 30.1 and 14.3 fold, respectively, compared to the levels in the cell cultures without the compounds (Fig 4A) . doi = 10.1371/journal.pone.0121629 id = cord-023766-qx0qdjmt author = Nirwan, Sonam title = Rhinovirus RNA Polymerase: Structure, Function, and Inhibitors date = 2018-11-02 keywords = HRV; HRV16; RNA; polymerase summary = doi = 10.1016/b978-0-12-815422-9.00011-5 id = cord-274943-fn3m14cn author = Philpott, Erin K title = Febrile Rhinovirus Illness During Pregnancy Is Associated With Low Birth Weight in Nepal date = 2017-04-06 keywords = HRV; illness; lbw summary = doi = 10.1093/ofid/ofx073 id = cord-317548-ft7lkpzq author = Proud, David title = Upper airway viral infections date = 2007-07-05 keywords = COPD; HRV; infection summary = doi = 10.1016/j.pupt.2007.06.004 id = cord-319942-ava86u8y author = Rady, Hanaa I. title = Prevalence of Human rhinovirus infection in young children with acute wheezing() date = 2018-05-08 keywords = HRV; Rhinovirus summary = doi = 10.1016/j.epag.2018.05.001 id = cord-002257-30s14h9j author = Ratnamohan, Vigneswary M. title = Phylogenetic analysis of human rhinoviruses collected over four successive years in Sydney, Australia date = 2016-08-09 keywords = HRV summary = doi = 10.1111/irv.12404 id = cord-007234-hcpa8ej5 author = Renwick, Neil title = A Recently Identified Rhinovirus Genotype Is Associated with Severe Respiratory-Tract Infection in Children in Germany date = 2007-12-15 keywords = HRV; PCR; respiratory summary = doi = 10.1086/524312 id = cord-270892-ycc3csyh author = Rollinger, Judith M. title = The human rhinovirus: human‐pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery date = 2010-12-13 keywords = Echinacea; Fig; HRV; RNA; Table; activity; antiviral; human; infection; rhinovirus summary = [79] [80] [81] [82] Taken together, the results of natural cold studies as well as of experimental infection in human volunteers clearly demonstrate that HRV are able to replicate in the upper as well as in the lower airways. Such an anti-HRV drug would have to be (i) with broad spectrum activity because of the high number of HRV serotypes, (ii) administered very early in infection to demonstrate a good antiviral effect because of the fast infection kinetics, (iii) very safe because of the broad application by millions of people, and (iv) directed against a highly conserved target with low risk of resistance development. The HRV-induced CPE, infectious virus titers, viral protein expression, and RNA synthesis can be chosen as parameters to evaluate the anti-HRV activity of compounds in cell-culture based assays. Due to the lack of a small-animal model for HRV infection until 2008, the experimental human challenge model has to be used to approve effects of potential antiviral drugs under controlled conditions in preclinical studies. doi = 10.1002/med.20176 id = cord-275275-wy8d6cw3 author = Rovida, Francesca title = Molecular detection of gastrointestinal viral infections in hospitalized patients date = 2013-09-12 keywords = HRV; PCR summary = doi = 10.1016/j.diagmicrobio.2013.07.020 id = cord-015893-e0fofgxq author = Ryhal, Bruce title = Viral Disease, Air Pollutants, Nanoparticles, and Asthma date = 2011-05-03 keywords = HRV; asthma; child; respiratory; viral summary = doi = 10.1007/978-1-4419-6836-4_11 id = cord-317499-mxt7stat author = Saraya, Takeshi title = Epidemiology of virus-induced asthma exacerbations: with special reference to the role of human rhinovirus date = 2014-05-26 keywords = HRV; IFN; infection summary = doi = 10.3389/fmicb.2014.00226 id = cord-352273-sras8r5z author = Saraya, Takeshi title = The molecular epidemiology of respiratory viruses associated with asthma attacks: A single-center observational study in Japan date = 2017-10-20 keywords = HRV; RSV summary = doi = 10.1097/md.0000000000008204 id = cord-327701-1qgaxcqq author = Scott, E. M. title = Risk factors and patterns of household clusters of respiratory viruses in rural Nepal date = 2019-10-14 keywords = HRV; RSV; household summary = In a prospective longitudinal study utilizing intensive weekly home-based active surveillance to evaluate the household transmission of nine respiratory viruses in rural South Asia, initial infection in young children was associated with the greatest risk of symptomatic respiratory virus household transmission with spread to infants occurring in 45% of transmission events. A higher proportion of initial infection among this group resulted in secondary cases compared to other age groups, including school-age children and mothers, a finding confirmed in our multivariable model of transmission incidence. While a model of Kenya transmission data supports immunizing school-age children to diminish transmission of the virus to infants, our study suggests that in rural South Asia, preschool-age children are more likely to transmit respiratory viruses to other household members [38] . Our study of non-influenza respiratory virus transmission within households in rural Nepal highlights the importance of targeting preschool-age children to prevent the spread of respiratory viral illness. doi = 10.1017/s0950268819001754 id = cord-307333-n6jc0jy3 author = Selvaggi, Carla title = Interferon lambda 1–3 expression in infants hospitalized for RSV or HRV associated bronchiolitis date = 2014-01-02 keywords = HRV; IFN; RSV; lambda summary = doi = 10.1016/j.jinf.2013.12.010 id = cord-005392-0pgcfk6b author = Sidoti, Francesca title = Development of a Quantitative Real-Time Nucleic Acid Sequence-Based Amplification Assay with an Internal Control Using Molecular Beacon Probes for Selective and Sensitive Detection of Human Rhinovirus Serotypes date = 2011-07-05 keywords = HRV; NASBA; RNA summary = title: Development of a Quantitative Real-Time Nucleic Acid Sequence-Based Amplification Assay with an Internal Control Using Molecular Beacon Probes for Selective and Sensitive Detection of Human Rhinovirus Serotypes In this study, we developed the first quantitative real-time nucleic acid sequence-based amplification assay with an internal control using molecular beacon probes for selective and sensitive detection of human rhinovirus serotypes. Aim of this study was to develop the first quantitative real-time nucleic acid sequence-based amplification assay internally controlled using molecular beacon for selective and sensitive detection of HRV serotypes. To estimate the dynamic range of the real-time NASBA assay (range of concentrations over which the method performs in a linear manner with an acceptable level of trueness and precision), we used HRV standard dilutions from 10 8 copies/ll to 1 copy/ll. Evaluation of a real-time nucleic acid sequence-based amplification assay using molecular beacons for detection of human immunodeficiency virus type 1 doi = 10.1007/s12033-011-9432-4 id = cord-281158-vjh9z7l4 author = Storch, Gregory A title = Respiratory Viruses in Babies: Important Insights From Down Under date = 2018-02-01 keywords = HRV; virus summary = doi = 10.1093/infdis/jix600 id = cord-009773-pbm2vs5h author = TRIGG, C. J. title = Bronchial inflammation and the common cold: a comparison of atopic and non‐atopic individuals date = 2006-04-27 keywords = HRV; atopic; bronchial; infection; subject summary = doi = 10.1111/j.1365-2222.1996.tb00593.x id = cord-253564-3y1wdepc author = Traves, Suzanne L title = Viral-associated exacerbations of asthma and COPD date = 2007-03-21 keywords = COPD; HRV; exacerbation summary = doi = 10.1016/j.coph.2006.11.010 id = cord-284889-hth8nf5b author = Tsukagoshi, Hiroyuki title = Molecular epidemiology of respiratory viruses in virus-induced asthma date = 2013-09-12 keywords = HRV; RSV; respiratory summary = doi = 10.3389/fmicb.2013.00278 id = cord-345817-rrf3dbnb author = WOOD, Lisa G. title = Persistence of rhinovirus RNA and IP‐10 gene expression after acute asthma date = 2011-01-27 keywords = HRV; RNA; visit summary = doi = 10.1111/j.1440-1843.2010.01897.x id = cord-018421-wy3mtafh author = Waghmare, Alpana title = Rhinovirus, Coronavirus, Enterovirus, and Bocavirus After Hematopoietic Cell Transplantation or Solid Organ Transplantation date = 2016-02-15 keywords = D68; HRV; infection; respiratory summary = doi = 10.1007/978-3-319-28797-3_32 id = cord-269922-ddpud48b author = Waghmare, Alpana title = Human Rhinovirus Infections in Hematopoietic Cell Transplant Recipients: Risk Score for Progression to Lower Respiratory Tract Infection date = 2018-12-08 keywords = HRV; LRTI; URTI summary = doi = 10.1016/j.bbmt.2018.12.005 id = cord-299537-lbx1plqx author = Wang, Wei title = Molecular monitoring of causative viruses in child acute respiratory infection in endemo-epidemic situations in Shanghai date = 2010-09-19 keywords = HRV; PCR; RSV summary = doi = 10.1016/j.jcv.2010.08.005 id = cord-324216-ce3wa889 author = Wang, Zheng title = Resequencing microarray probe design for typing genetically diverse viruses: human rhinoviruses and enteroviruses date = 2008-12-01 keywords = HEV; HRV; flu; sequence summary = doi = 10.1186/1471-2164-9-577 id = cord-000374-gt2pwc9b author = Yang, Albert C. title = Clustering Heart Rate Dynamics Is Associated with β-Adrenergic Receptor Polymorphisms: Analysis by Information-Based Similarity Index date = 2011-05-04 keywords = -ar; HRV; IBS; heart summary = With these considerations in mind, in the present study, we introduce a bottom-up genotype-phenotype analysis to investigate the association between genetic polymorphisms and autonomic control of heart rate dynamics, using three common polymorphisms in genes encoding b-adrenergic receptor (b-AR) as an example. The analyses of the present study were two-fold: 1) a nonrandomness index [17] derived from the IBS method was applied to quantify the nonlinear aspect of HRV according to b-AR genotype and to test the correlation of this index with standard HRV indices; and 2) using agglomerative hierarchical cluster analysis, we unsupervisedly categorized these subjects into clusters based on pairwise dissimilarity among heart rate dynamics, and then we investigated the association of these clustering patterns with b-AR gene polymorphisms. The data presented in this study demonstrate a significant association of a common b 2 -AR polymorphism, Arg16Gly, with the non-randomness index, a nonlinear HRV measure derived from the IBS method. doi = 10.1371/journal.pone.0019232 id = cord-278438-bnjkmegh author = Yuan, Lijuan title = Induction of mucosal immune responses and protection against enteric viruses: rotavirus infection of gnotobiotic pigs as a model date = 2002-09-10 keywords = ASC; HRV summary = doi = 10.1016/s0165-2427(02)00046-6 id = cord-336713-if6f58ii author = Yuan, Lijuan title = Short-term immunoglobulin A B-cell memory resides in intestinal lymphoid tissues but not in bone marrow of gnotobiotic pigs inoculated with Wa human rotavirus date = 2001-06-01 keywords = ASC; HRV summary = To investigate the development and sites of residence of intestinal memory B cells, and their role in protective immunity to reinfection with an enteric virus, we assessed the association between memory B cell and antibody-secreting cell (ASC) responses and protection using a gnotobiotic pig model for human rotavirus (HRV) infection and diarrhoea. The isotypes, quantities and tissue distribution of rotavirus-specific memory B cells and ASC were evaluated prechallenge (28 and 83 postinoculation days [PID]) and postchallenge (7 postchallenge days [PCD]), using enzyme-linked immunospot (ELISPOT) assay, in gnotobiotic pigs inoculated once with virulent or three times with attenuated HRV and challenged at PID 28 with the corresponding virulent HRV. In previous studies, 3, 4 we reported that the number of rotavirus-speci®c immunoglobulin A (IgA) antibody-secreting cells (ASC) present in the intestinal lamina propria of gnotobiotic pigs at the time of challenge (primary ASC) correlates with protection against infection and diarrhoea when challenged with human rotavirus (HRV). doi = 10.1046/j.1365-2567.2001.01229.x id = cord-356027-ckdx56j1 author = Zheng, Shou-Yan title = Association between secondary thrombocytosis and viral respiratory tract infections in children date = 2016-03-11 keywords = HRV; RSV summary = doi = 10.1038/srep22964 id = cord-318016-987w5i6t author = de Almeida, Marina B. title = Rhinovirus C and Respiratory Exacerbations in Children with Cystic Fibrosis date = 2010-06-17 keywords = HRV summary = To investigate a possible role for human rhinovirus C in respiratory exacerbations of children with cystic fibrosis, we conducted microbiologic testing on respiratory specimens from 103 such patients in São Paulo, Brazil, during 2006–2007. To investigate a possible role for human rhinovirus C in respiratory exacerbations of children with cystic fi brosis, we conducted microbiologic testing on respiratory specimens from 103 such patients in São Paulo, Brazil, during 2006-2007. In the study reported here, we obtained samples from patients during routine visits and exacerbations, which enabled us to identify a distinct role of different HRV subtypes. (3) , in which they used real-time nucleic acid sequence-based amplifi cation in conjunction with molecular markers to investigate the presence of 9 respiratory viruses in children with CF, described an association of viral infections with respiratory exacerbations, particularly those caused by infl uenza A, infl uenza B, and rhinovirus (3). doi = 10.3201/eid1606.100063 id = cord-010075-72jodunj author = nan title = Paediatric SIG: Poster Session date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_12.x id = cord-023298-ysur3sjq author = nan title = Respiratory Nurses SIG: Poster Session date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_16.x id = cord-023302-p9pxz44a author = nan title = Cystic Fibrosis SIG: Poster Session date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_7.x id = cord-023305-5lb9kho6 author = nan title = Oliv SIG: Poster Session date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_11.x id = cord-023314-rwjxk8v4 author = nan title = Asthma & Allergy SIG: Poster Session 1 date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_1.x id = cord-023333-b7w9zrl6 author = nan title = Oeld/Population Health SIG: Poster Session date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_10.x id = cord-023343-y17z9w2x author = nan title = COPD SIG: Poster Session 1 date = 2011-03-21 keywords = ASM; COPD; FEV; HRV; Interest; Nil; airway; cell; increase; method; patient; result; study summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. doi = 10.1111/j.1440-1843.2011.01937_5.x