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J.; Al‐Nakib, W. title: Direct detection of rhinoviruses by an enzyme‐linked immunosorbent assay date: 2005-12-07 journal: J Med Virol DOI: 10.1002/jmv.1890230211 sha: doc_id: 9922 cord_uid: t1hoox6e file: cache/cord-016783-8x05oh5q.json key: cord-016783-8x05oh5q authors: Arruda, L. Karla; Solé, Dirceu; Naspitz, Charles K. title: Early Interventions in Allergic Diseases date: 2010 journal: Allergy Frontiers: Therapy and Prevention DOI: 10.1007/978-4-431-99362-9_23 sha: doc_id: 16783 cord_uid: 8x05oh5q file: cache/cord-009877-3cyz6o9c.json key: cord-009877-3cyz6o9c authors: Barclay, Wendy S.; Callow, Kathleen A.; Sergeant, Marianne; Ai‐Nakib, Widad title: Evaluation of an enzyme‐linked immunosorbent assay that measures rhinovirus‐specific antibodies in human sera and nasal secretions date: 2005-12-07 journal: J Med Virol DOI: 10.1002/jmv.1890250411 sha: doc_id: 9877 cord_uid: 3cyz6o9c file: cache/cord-005392-0pgcfk6b.json key: cord-005392-0pgcfk6b authors: Sidoti, Francesca; Bergallo, Massimiliano; Terlizzi, Maria Elena; Piasentin Alessio, Elsa; Astegiano, Sara; Gasparini, Giorgio; Cavallo, Rossana title: Development of a Quantitative Real-Time Nucleic Acid Sequence-Based Amplification Assay with an Internal Control Using Molecular Beacon Probes for Selective and Sensitive Detection of Human Rhinovirus Serotypes date: 2011-07-05 journal: Mol Biotechnol DOI: 10.1007/s12033-011-9432-4 sha: doc_id: 5392 cord_uid: 0pgcfk6b file: cache/cord-004749-wyzb8v4a.json key: cord-004749-wyzb8v4a authors: Forsyth, M.; Al-Nakib, W.; Chadwick, P.; Stanway, G.; Hughes, P. J.; Leckie, G.; Almond, J. W.; Tyrrell, D. A. J. title: Rhinovirus detection using probes from the 5′ and 3′ end of the genome date: 1989 journal: Arch Virol DOI: 10.1007/bf01313878 sha: doc_id: 4749 cord_uid: wyzb8v4a file: cache/cord-004694-43yvs52a.json key: cord-004694-43yvs52a authors: Han, Tae-Hee; Chung, Ju-Young; Hwang, Eung-Soo; Koo, Ja-Wook title: Detection of human rhinovirus C in children with acute lower respiratory tract infections in South Korea date: 2009-05-05 journal: Arch Virol DOI: 10.1007/s00705-009-0383-z sha: doc_id: 4694 cord_uid: 43yvs52a file: cache/cord-007234-hcpa8ej5.json key: cord-007234-hcpa8ej5 authors: Renwick, Neil; Schweiger, Brunhilde; Kapoor, Vishal; Liu, Zhiqiang; Villari, Joseph; Bullmann, Reinhard; Miething, Robert; Briese, Thomas; Lipkin, W. Ian title: A Recently Identified Rhinovirus Genotype Is Associated with Severe Respiratory-Tract Infection in Children in Germany date: 2007-12-15 journal: J Infect Dis DOI: 10.1086/524312 sha: doc_id: 7234 cord_uid: hcpa8ej5 file: cache/cord-018421-wy3mtafh.json key: cord-018421-wy3mtafh authors: Waghmare, Alpana; Boeckh, Michael title: Rhinovirus, Coronavirus, Enterovirus, and Bocavirus After Hematopoietic Cell Transplantation or Solid Organ Transplantation date: 2016-02-15 journal: Transplant Infections DOI: 10.1007/978-3-319-28797-3_32 sha: doc_id: 18421 cord_uid: wy3mtafh file: cache/cord-258336-zs04l3s0.json key: cord-258336-zs04l3s0 authors: Leotte, Jaqueline; Trombetta, Hygor; Faggion, Heloisa Z.; Almeida, Bernardo M.; Nogueira, Meri B.; Vidal, Luine R.; Raboni, Sonia M. title: Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years date: 2017-06-30 journal: Jornal de Pediatria DOI: 10.1016/j.jped.2016.07.004 sha: doc_id: 258336 cord_uid: zs04l3s0 file: cache/cord-009773-pbm2vs5h.json key: cord-009773-pbm2vs5h authors: TRIGG, C. J.; NICHOLSON, K. G.; WANG, J. H.; IRELAND, D. C.; JORDAN, S.; DUDDLE, J. M.; HAMILTON, S.; DAVIES, R. J. title: Bronchial inflammation and the common cold: a comparison of atopic and non‐atopic individuals date: 2006-04-27 journal: Clin Exp Allergy DOI: 10.1111/j.1365-2222.1996.tb00593.x sha: doc_id: 9773 cord_uid: pbm2vs5h file: cache/cord-023766-qx0qdjmt.json key: cord-023766-qx0qdjmt authors: Nirwan, Sonam; Kakkar, Rita title: Rhinovirus RNA Polymerase: Structure, Function, and Inhibitors date: 2018-11-02 journal: Viral Polymerases DOI: 10.1016/b978-0-12-815422-9.00011-5 sha: doc_id: 23766 cord_uid: qx0qdjmt file: cache/cord-000082-jy7j8sh0.json key: cord-000082-jy7j8sh0 authors: Huang, Ting; Wang, Wei; Bessaud, Mael; Ren, Peijun; Sheng, Jun; Yan, Huajie; Zhang, Jing; Lin, Xin; Wang, Yongjin; Delpeyroux, Francis; Deubel, Vincent title: Evidence of Recombination and Genetic Diversity in Human Rhinoviruses in Children with Acute Respiratory Infection date: 2009-07-27 journal: PLoS One DOI: 10.1371/journal.pone.0006355 sha: doc_id: 82 cord_uid: jy7j8sh0 file: cache/cord-023298-ysur3sjq.json key: cord-023298-ysur3sjq authors: nan title: Respiratory Nurses SIG: Poster Session date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_16.x sha: doc_id: 23298 cord_uid: ysur3sjq file: cache/cord-253564-3y1wdepc.json key: cord-253564-3y1wdepc authors: Traves, Suzanne L; Proud, David title: Viral-associated exacerbations of asthma and COPD date: 2007-03-21 journal: Curr Opin Pharmacol DOI: 10.1016/j.coph.2006.11.010 sha: doc_id: 253564 cord_uid: 3y1wdepc file: cache/cord-268093-ta6k0uyz.json key: cord-268093-ta6k0uyz authors: Etemadi, Mohammad Reza; Othman, Norlijah; Savolainen-Kopra, Carita; Sekawi, Zamberi; Wahab, NoraAbd; Sann, Lye Munn title: Biodiversity and clinico-demographic characteristics of human rhinoviruses from hospitalized children with acute lower respiratory tract infections in Malaysia() date: 2013-08-07 journal: J Clin Virol DOI: 10.1016/j.jcv.2013.05.017 sha: doc_id: 268093 cord_uid: ta6k0uyz file: cache/cord-272125-dez1nzg4.json key: cord-272125-dez1nzg4 authors: Jartti, T.; Kuusipalo, H.; Vuorinen, T.; Söderlund‐Venermo, M.; Allander, T.; Waris, M.; Hartiala, J.; Ruuskanen, O. title: Allergic sensitization is associated with rhinovirus‐, but not other virus‐, induced wheezing in children date: 2010-10-26 journal: Pediatr Allergy Immunol DOI: 10.1111/j.1399-3038.2010.01059.x sha: doc_id: 272125 cord_uid: dez1nzg4 file: cache/cord-281158-vjh9z7l4.json key: cord-281158-vjh9z7l4 authors: Storch, Gregory A title: Respiratory Viruses in Babies: Important Insights From Down Under date: 2018-02-01 journal: J Infect Dis DOI: 10.1093/infdis/jix600 sha: doc_id: 281158 cord_uid: vjh9z7l4 file: cache/cord-252347-vnn4135b.json key: cord-252347-vnn4135b authors: Lee, Wai-Ming; Kiesner, Christin; Pappas, Tressa; Lee, Iris; Grindle, Kris; Jartti, Tuomas; Jakiela, Bogdan; Lemanske, Robert F.; Shult, Peter A.; Gern, James E. title: A Diverse Group of Previously Unrecognized Human Rhinoviruses Are Common Causes of Respiratory Illnesses in Infants date: 2007-10-03 journal: PLoS One DOI: 10.1371/journal.pone.0000966 sha: doc_id: 252347 cord_uid: vnn4135b file: cache/cord-289358-4abypk6o.json key: cord-289358-4abypk6o authors: Asner, Sandra A.; Petrich, Astrid; Hamid, Jemila S.; Mertz, Dominik; Richardson, Susan E.; Smieja, Marek title: Clinical severity of rhinovirus/enterovirus compared to other respiratory viruses in children date: 2014-05-07 journal: Influenza Other Respir Viruses DOI: 10.1111/irv.12255 sha: doc_id: 289358 cord_uid: 4abypk6o file: cache/cord-291238-myjyw8ei.json key: cord-291238-myjyw8ei authors: Longtin, Jean; Marchand-Austin, Alex; Winter, Anne-Luise; Patel, Samir; Eshaghi, Alireza; Jamieson, Frances; Low, Donald E.; Gubbay, Jonathan B. title: Rhinovirus Outbreaks in Long-term Care Facilities, Ontario, Canada date: 2010-09-17 journal: Emerg Infect Dis DOI: 10.3201/eid1609.100476 sha: doc_id: 291238 cord_uid: myjyw8ei file: cache/cord-023713-daz2vokz.json key: cord-023713-daz2vokz authors: Devereux, Graham; Matsui, Elizabeth C.; Burney, Peter G.J. title: Epidemiology of Asthma and Allergic Airway Diseases date: 2013-09-06 journal: Middleton's Allergy DOI: 10.1016/b978-0-323-08593-9.00049-8 sha: doc_id: 23713 cord_uid: daz2vokz file: cache/cord-015893-e0fofgxq.json key: cord-015893-e0fofgxq authors: Ryhal, Bruce title: Viral Disease, Air Pollutants, Nanoparticles, and Asthma date: 2011-05-03 journal: Bronchial Asthma DOI: 10.1007/978-1-4419-6836-4_11 sha: doc_id: 15893 cord_uid: e0fofgxq file: cache/cord-278438-bnjkmegh.json key: cord-278438-bnjkmegh authors: Yuan, Lijuan; Saif, Linda J title: Induction of mucosal immune responses and protection against enteric viruses: rotavirus infection of gnotobiotic pigs as a model date: 2002-09-10 journal: Vet Immunol Immunopathol DOI: 10.1016/s0165-2427(02)00046-6 sha: doc_id: 278438 cord_uid: bnjkmegh file: cache/cord-010075-72jodunj.json key: cord-010075-72jodunj authors: nan title: Paediatric SIG: Poster Session date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_12.x sha: doc_id: 10075 cord_uid: 72jodunj file: cache/cord-010160-wk8k2igu.json key: cord-010160-wk8k2igu authors: Chandrasekaran, Alamelu; Manji, Ryhana; Joseph, Ansamma; Zhang, Fan; Ginocchio, Christine C. title: Broad reactivity of the Luminex xTAG Respiratory Virus Panel (RVP) assay for the detection of human rhinoviruses date: 2012-01-04 journal: J Clin Virol DOI: 10.1016/j.jcv.2011.12.006 sha: doc_id: 10160 cord_uid: wk8k2igu file: cache/cord-275275-wy8d6cw3.json key: cord-275275-wy8d6cw3 authors: Rovida, Francesca; Campanini, Giulia; Piralla, Antonio; Adzasehoun, Kodjo Messan Guy; Sarasini, Antonella; Baldanti, Fausto title: Molecular detection of gastrointestinal viral infections in hospitalized patients date: 2013-09-12 journal: Diagn Microbiol Infect Dis DOI: 10.1016/j.diagmicrobio.2013.07.020 sha: doc_id: 275275 cord_uid: wy8d6cw3 file: cache/cord-284875-hsa2r7ns.json key: cord-284875-hsa2r7ns authors: Bourdillon, N.; Yazdani, S.; Schmitt, L.; Millet, G. P. title: Effects of COVID-19 lockdown on heart rate variability date: 2020-08-01 journal: nan DOI: 10.1101/2020.07.30.20165118 sha: doc_id: 284875 cord_uid: hsa2r7ns file: cache/cord-307333-n6jc0jy3.json key: cord-307333-n6jc0jy3 authors: Selvaggi, Carla; Pierangeli, Alessandra; Fabiani, Marco; Spano, Lucia; Nicolai, Ambra; Papoff, Paola; Moretti, Corrado; Midulla, Fabio; Antonelli, Guido; Scagnolari, Carolina title: Interferon lambda 1–3 expression in infants hospitalized for RSV or HRV associated bronchiolitis date: 2014-01-02 journal: J Infect DOI: 10.1016/j.jinf.2013.12.010 sha: doc_id: 307333 cord_uid: n6jc0jy3 file: cache/cord-309497-3v0asfa7.json key: cord-309497-3v0asfa7 authors: Asner, Sandra; Peci, Adriana; Marchand‐Austin, Alex; Winter, Anne‐Luise; Olsha, Romy; Kristjanson, Erik; Low, Donald E.; Gubbay, Jonathan B. title: Respiratory viral infections in institutions from late stage of the first and second waves of pandemic influenza A (H1N1) 2009, Ontario, Canada date: 2012-02-21 journal: Influenza Other Respir Viruses DOI: 10.1111/j.1750-2659.2012.00336.x sha: doc_id: 309497 cord_uid: 3v0asfa7 file: cache/cord-319942-ava86u8y.json key: cord-319942-ava86u8y authors: Rady, Hanaa I.; Kholy, Amani El title: Prevalence of Human rhinovirus infection in young children with acute wheezing() date: 2018-05-08 journal: Gaz Egypt Paediatr Assoc DOI: 10.1016/j.epag.2018.05.001 sha: doc_id: 319942 cord_uid: ava86u8y file: cache/cord-023305-5lb9kho6.json key: cord-023305-5lb9kho6 authors: nan title: Oliv SIG: Poster Session date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_11.x sha: doc_id: 23305 cord_uid: 5lb9kho6 file: cache/cord-290773-kgb8r561.json key: cord-290773-kgb8r561 authors: Ahn, Jong Gyun; Kim, Dong Soo; Kim, Ki Hwan title: Clinical characteristics and cytokine profiles of children with acute lower respiratory tract infections caused by human rhinovirus date: 2018-07-03 journal: PLoS One DOI: 10.1371/journal.pone.0198624 sha: doc_id: 290773 cord_uid: kgb8r561 file: cache/cord-314841-b5l6epy3.json key: cord-314841-b5l6epy3 authors: Falsey, Ann Regina title: Respiratory viral infections date: 2019-08-15 journal: Genomic and Precision Medicine DOI: 10.1016/b978-0-12-801496-7.00009-5 sha: doc_id: 314841 cord_uid: b5l6epy3 file: cache/cord-299537-lbx1plqx.json key: cord-299537-lbx1plqx authors: Wang, Wei; Cavailler, Philippe; Ren, Peijun; Zhang, Jing; Dong, Wei; Yan, Huajie; Mardy, Sek; Cailhol, Johann; Buchy, Philippe; Sheng, Jun; Fontanet, Arnaud; Deubel, Vincent title: Molecular monitoring of causative viruses in child acute respiratory infection in endemo-epidemic situations in Shanghai date: 2010-09-19 journal: J Clin Virol DOI: 10.1016/j.jcv.2010.08.005 sha: doc_id: 299537 cord_uid: lbx1plqx file: cache/cord-307602-2cmgu7rf.json key: cord-307602-2cmgu7rf authors: McErlean, P.; Shackelton, L.A.; Lambert, S.B.; Nissen, M.D.; Sloots, T.P.; Mackay, I.M. title: Characterisation of a newly identified human rhinovirus, HRV-QPM, discovered in infants with bronchiolitis date: 2007-05-07 journal: J Clin Virol DOI: 10.1016/j.jcv.2007.03.012 sha: doc_id: 307602 cord_uid: 2cmgu7rf file: cache/cord-016499-5iqpl23p.json key: cord-016499-5iqpl23p authors: Mackay, Ian M.; Arden, Katherine E. title: Rhinoviruses date: 2014-02-27 journal: Viral Infections of Humans DOI: 10.1007/978-1-4899-7448-8_29 sha: doc_id: 16499 cord_uid: 5iqpl23p file: cache/cord-259997-8f8di4eu.json key: cord-259997-8f8di4eu authors: Botti, Chiara; Micillo, Alberto; Ricci, Giuseppe; Russo, Adolfo; Denisco, Alberto; Cantile, Monica; Scognamiglio, Giosuè; De Rosa, Antonio; Botti, Gerardo title: Characterization of respiratory infection viruses in hospitalized children from Naples province in Southern Italy date: 2018-04-13 journal: Exp Ther Med DOI: 10.3892/etm.2018.6061 sha: doc_id: 259997 cord_uid: 8f8di4eu file: cache/cord-270892-ycc3csyh.json key: cord-270892-ycc3csyh authors: Rollinger, Judith M.; Schmidtke, Michaela title: The human rhinovirus: human‐pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery date: 2010-12-13 journal: Med Res Rev DOI: 10.1002/med.20176 sha: doc_id: 270892 cord_uid: ycc3csyh file: cache/cord-307990-skrye40w.json key: cord-307990-skrye40w authors: Hai, Le Thanh; Bich, Vu Thi Ngoc; Ngai, Le Kien; Diep, Nguyen Thi Ngoc; Phuc, Phan Huu; Hung, Viet Pham; Taylor, Walter R.; Horby, Peter; Liem, Nguyen Thanh; Wertheim, Heiman F.L. title: Fatal Respiratory Infections Associated with Rhinovirus Outbreak, Vietnam date: 2012-11-17 journal: Emerg Infect Dis DOI: 10.3201/eid1811.120607 sha: doc_id: 307990 cord_uid: skrye40w file: cache/cord-280391-5kiu2pb6.json key: cord-280391-5kiu2pb6 authors: Akinloye, Oluwabukola M.; Rönkkö, Esa; Savolainen-Kopra, Carita; Ziegler, Thedi; Iwalokun, Bamidele A.; Deji-Agboola, Mope A.; Oluwadun, Afolabi; Roivainen, Merja; Adu, Festus D.; Hovi, Tapani title: Specific Viruses Detected in Nigerian Children in Association with Acute Respiratory Disease date: 2011-10-11 journal: J Trop Med DOI: 10.1155/2011/690286 sha: doc_id: 280391 cord_uid: 5kiu2pb6 file: cache/cord-023302-p9pxz44a.json key: cord-023302-p9pxz44a authors: nan title: Cystic Fibrosis SIG: Poster Session date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_7.x sha: doc_id: 23302 cord_uid: p9pxz44a file: cache/cord-023314-rwjxk8v4.json key: cord-023314-rwjxk8v4 authors: nan title: Asthma & Allergy SIG: Poster Session 1 date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_1.x sha: doc_id: 23314 cord_uid: rwjxk8v4 file: cache/cord-325137-6c6er06a.json key: cord-325137-6c6er06a authors: Moser, Lindsey A.; Ramirez-Carvajal, Lisbeth; Puri, Vinita; Pauszek, Steven J.; Matthews, Krystal; Dilley, Kari A.; Mullan, Clancy; McGraw, Jennifer; Khayat, Michael; Beeri, Karen; Yee, Anthony; Dugan, Vivien; Heise, Mark T.; Frieman, Matthew B.; Rodriguez, Luis L.; Bernard, Kristen A.; Wentworth, David E.; Stockwell, Timothy B.; Shabman, Reed S. title: A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses date: 2016-06-07 journal: mSystems DOI: 10.1128/msystems.00039-15 sha: doc_id: 325137 cord_uid: 6c6er06a file: cache/cord-281162-2pu7x5rj.json key: cord-281162-2pu7x5rj authors: Etemadi, Mohammad Reza; jalilian, Farid Azizi; Othman, Norlijah; Lye, Munn-Sann; Ansari, Sara; Yubbu, Putri; Sekawi, Zamberi title: Diversity of respiratory viruses detected among hospitalized children with acute lower respiratory tract infections at Hospital Serdang, Malaysia date: 2019-03-22 journal: J Virol Methods DOI: 10.1016/j.jviromet.2019.03.013 sha: doc_id: 281162 cord_uid: 2pu7x5rj file: cache/cord-103367-fxvvndic.json key: cord-103367-fxvvndic authors: Liu, N.; 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L.; Koh, Z. X.; Leow, S. L.; Ho, A. F. W.; Guo, D.; Ong, M. E. H. title: Machine learning dimensionality reduction for heart rate n-variability (HRnV) based risk stratification of chest pain patients in the emergency department date: 2020-07-06 journal: nan DOI: 10.1101/2020.07.05.20146571 sha: doc_id: 103367 cord_uid: fxvvndic file: cache/cord-287063-kheek4lx.json key: cord-287063-kheek4lx authors: Carroll, Kecia N.; Gebretsadik, Tebeb; Minton, Patricia; Woodward, Kimberly; Liu, Zhouwen; Miller, E. Kathryn; Williams, John V.; Dupont, William D.; Hartert, Tina V. title: Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections date: 2012-02-14 journal: J Allergy Clin Immunol DOI: 10.1016/j.jaci.2012.01.045 sha: doc_id: 287063 cord_uid: kheek4lx file: cache/cord-299672-dq1y1gkc.json key: cord-299672-dq1y1gkc authors: Leung, Ting Fan; To, Man Yin; Yeung, Apple C.M.; Wong, Yun Sze; Wong, Gary W.K.; Chan, Paul K.S. title: Multiplex Molecular Detection of Respiratory Pathogens in Children With Asthma Exacerbation date: 2010-02-28 journal: Chest DOI: 10.1378/chest.09-1250 sha: doc_id: 299672 cord_uid: dq1y1gkc file: cache/cord-310171-1fmsxx2s.json key: cord-310171-1fmsxx2s authors: Goffard, Anne; Lambert, Valérie; Salleron, Julia; Herwegh, Stéphanie; Engelmann, Ilka; Pinel, Claudine; Pin, Isabelle; Perrez, Thierry; Prévotat, Anne; Dewilde, Anny; Delhaes, Laurence title: Virus and cystic fibrosis: Rhinoviruses are associated with exacerbations in adult patients() date: 2014-02-25 journal: J Clin Virol DOI: 10.1016/j.jcv.2014.02.005 sha: doc_id: 310171 cord_uid: 1fmsxx2s file: cache/cord-324216-ce3wa889.json key: cord-324216-ce3wa889 authors: Wang, Zheng; Malanoski, Anthony P; Lin, Baochuan; Kidd, Carolyn; Long, Nina C; Blaney, Kate M; Thach, Dzung C; Tibbetts, Clark; Stenger, David A title: Resequencing microarray probe design for typing genetically diverse viruses: human rhinoviruses and enteroviruses date: 2008-12-01 journal: BMC Genomics DOI: 10.1186/1471-2164-9-577 sha: doc_id: 324216 cord_uid: ce3wa889 file: cache/cord-316245-n6tmn4ph.json key: cord-316245-n6tmn4ph authors: Cui, Binglin; Zhang, Dangui; Pan, Hui; Zhang, Fan; Farrar, Jeremy; Law, Frieda; van Doorn, H Rogier; Wu, Beiyan; Ba-Thein, William title: Viral aetiology of acute respiratory infections among children and associated meteorological factors in southern China date: 2015-03-13 journal: BMC Infect Dis DOI: 10.1186/s12879-015-0863-6 sha: doc_id: 316245 cord_uid: n6tmn4ph file: cache/cord-317198-mean7sj9.json key: cord-317198-mean7sj9 authors: Giamberardin, Heloisa I.G.; Homsani, Sheila; Bricks, Lucia F.; Pacheco, Ana P.O.; Guedes, Matilde; Debur, Maria C.; Raboni, Sonia M. title: Clinical and epidemiological features of respiratory virus infections in preschool children over two consecutive influenza seasons in southern Brazil date: 2016-02-09 journal: J Med Virol DOI: 10.1002/jmv.24477 sha: doc_id: 317198 cord_uid: mean7sj9 file: cache/cord-316319-m6uha1qn.json key: cord-316319-m6uha1qn authors: Daleno, Cristina; Piralla, Antonio; Scala, Alessia; Senatore, Laura; Principi, Nicola; Esposito, Susanna title: Phylogenetic Analysis of Human Rhinovirus Isolates Collected from Otherwise Healthy Children with Community-Acquired Pneumonia during Five Successive Years date: 2013-11-19 journal: PLoS One DOI: 10.1371/journal.pone.0080614 sha: doc_id: 316319 cord_uid: m6uha1qn file: cache/cord-327344-8gi1wb76.json key: cord-327344-8gi1wb76 authors: Gambarino, Stefano; Costa, Cristina; Elia, Mariateresa; Sidoti, Francesca; Mantovani, Samantha; Gruosso, Valentina; Bergallo, Massimiliano; Cavallo, Rossana title: Development of a RT Real-Time PCR for the Detection and Quantification of Human Rhinoviruses date: 2009-03-17 journal: Mol Biotechnol DOI: 10.1007/s12033-009-9164-x sha: doc_id: 327344 cord_uid: 8gi1wb76 file: cache/cord-269922-ddpud48b.json key: cord-269922-ddpud48b authors: Waghmare, Alpana; Xie, Hu; Kuypers, Jane; Sorror, Mohamed L.; Jerome, Keith R.; Englund, Janet A.; Boeckh, Michael; Leisenring, Wendy M. title: Human Rhinovirus Infections in Hematopoietic Cell Transplant Recipients: Risk Score for Progression to Lower Respiratory Tract Infection date: 2018-12-08 journal: Biol Blood Marrow Transplant DOI: 10.1016/j.bbmt.2018.12.005 sha: doc_id: 269922 cord_uid: ddpud48b file: cache/cord-318016-987w5i6t.json key: cord-318016-987w5i6t authors: de Almeida, Marina B.; Zerbinati, Rodrigo M.; Tateno, Adriana F.; Oliveira, Cristina M.; Romão, Renata M.; Rodrigues, Joaquim C.; Pannuti, Cláudio S.; da Silva Filho, Luiz Vicente F. title: Rhinovirus C and Respiratory Exacerbations in Children with Cystic Fibrosis date: 2010-06-17 journal: Emerg Infect Dis DOI: 10.3201/eid1606.100063 sha: doc_id: 318016 cord_uid: 987w5i6t file: cache/cord-274943-fn3m14cn.json key: cord-274943-fn3m14cn authors: Philpott, Erin K; Englund, Janet A; Katz, Joanne; Tielsch, James; Khatry, Subarna; LeClerq, Stephen C; Shrestha, Laxman; Kuypers, Jane; Magaret, Amalia S; Steinhoff, Mark C; Chu, Helen Y title: Febrile Rhinovirus Illness During Pregnancy Is Associated With Low Birth Weight in Nepal date: 2017-04-06 journal: Open Forum Infect Dis DOI: 10.1093/ofid/ofx073 sha: doc_id: 274943 cord_uid: fn3m14cn file: cache/cord-225218-x32a4sp3.json key: cord-225218-x32a4sp3 authors: Filntisis, Panagiotis P.; Zlatintsi, Athanasia; Efthymiou, Niki; Kalisperakis, Emmanouil; Karantinos, Thomas; Lazaridi, Marina; Smyrnis, Nikolaos; Maragos, Petros title: Identifying differences in physical activity and autonomic function patterns between psychotic patients and controls over a long period of continuous monitoring using wearable sensors date: 2020-10-30 journal: nan DOI: nan sha: doc_id: 225218 cord_uid: x32a4sp3 file: cache/cord-327701-1qgaxcqq.json key: cord-327701-1qgaxcqq authors: Scott, E. M.; Magaret, A.; Kuypers, J.; Tielsch, J. M.; Katz, J.; Khatry, S. K.; Stewart, L.; Shrestha, L.; LeClerq, S. C.; Englund, J. A.; Chu, H. Y. title: Risk factors and patterns of household clusters of respiratory viruses in rural Nepal date: 2019-10-14 journal: Epidemiol Infect DOI: 10.1017/s0950268819001754 sha: doc_id: 327701 cord_uid: 1qgaxcqq file: cache/cord-291486-5h96msv1.json key: cord-291486-5h96msv1 authors: Kistler, Amy; Avila, Pedro C.; Rouskin, Silvi; Wang, David; Ward, Theresa; Yagi, Shigeo; Schnurr, David; Ganem, Don; DeRisi, Joseph L.; Boushey, Homer A. title: Pan-Viral Screening of Respiratory Tract Infections in Adults With and Without Asthma Reveals Unexpected Human Coronavirus and Human Rhinovirus Diversity date: 2007-09-15 journal: J Infect Dis DOI: 10.1086/520816 sha: doc_id: 291486 cord_uid: 5h96msv1 file: cache/cord-023343-y17z9w2x.json key: cord-023343-y17z9w2x authors: nan title: COPD SIG: Poster Session 1 date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_5.x sha: doc_id: 23343 cord_uid: y17z9w2x file: cache/cord-022084-hap7flng.json key: cord-022084-hap7flng authors: ARRUDA, EURICO; CINTRA, OTAVIO A.L.; HAYDEN, FREDERICK G. title: Respiratory Tract Viral Infections date: 2009-05-15 journal: Tropical Infectious Diseases DOI: 10.1016/b978-0-443-06668-9.50064-8 sha: doc_id: 22084 cord_uid: hap7flng file: cache/cord-317499-mxt7stat.json key: cord-317499-mxt7stat authors: Saraya, Takeshi; Kurai, Daisuke; Ishii, Haruyuki; Ito, Anri; Sasaki, Yoshiko; Niwa, Shoichi; Kiyota, Naoko; Tsukagoshi, Hiroyuki; Kozawa, Kunihisa; Goto, Hajime; Takizawa, Hajime title: Epidemiology of virus-induced asthma exacerbations: with special reference to the role of human rhinovirus date: 2014-05-26 journal: Front Microbiol DOI: 10.3389/fmicb.2014.00226 sha: doc_id: 317499 cord_uid: mxt7stat file: cache/cord-317548-ft7lkpzq.json key: cord-317548-ft7lkpzq authors: Proud, David title: Upper airway viral infections date: 2007-07-05 journal: Pulm Pharmacol Ther DOI: 10.1016/j.pupt.2007.06.004 sha: doc_id: 317548 cord_uid: ft7lkpzq file: cache/cord-023333-b7w9zrl6.json key: cord-023333-b7w9zrl6 authors: nan title: Oeld/Population Health SIG: Poster Session date: 2011-03-21 journal: Respirology DOI: 10.1111/j.1440-1843.2011.01937_10.x sha: doc_id: 23333 cord_uid: b7w9zrl6 file: cache/cord-284889-hth8nf5b.json key: cord-284889-hth8nf5b authors: Tsukagoshi, Hiroyuki; Ishioka, Taisei; Noda, Masahiro; Kozawa, Kunihisa; Kimura, Hirokazu title: Molecular epidemiology of respiratory viruses in virus-induced asthma date: 2013-09-12 journal: Front Microbiol DOI: 10.3389/fmicb.2013.00278 sha: doc_id: 284889 cord_uid: hth8nf5b file: cache/cord-327610-cm3vkpcn.json key: cord-327610-cm3vkpcn authors: Fukuda, Yosuke; Akimoto, Kaho; Homma, Tetsuya; Baker, Jonathan R; Ito, Kazuhiro; Barnes, Peter J; Sagara, Hironori title: Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach date: 2020-08-13 journal: J Clin Med DOI: 10.3390/jcm9082623 sha: doc_id: 327610 cord_uid: cm3vkpcn file: cache/cord-316932-fia1w9jt.json key: cord-316932-fia1w9jt authors: Ireland, D. C.; Kent, J.; Nicholson, K. G. title: Improved detection of rhinoviruses in nasal and throat swabs by seminested RT‐PCR date: 2005-12-07 journal: J Med Virol DOI: 10.1002/jmv.1890400204 sha: doc_id: 316932 cord_uid: fia1w9jt file: cache/cord-321989-1enjopig.json key: cord-321989-1enjopig authors: Li, Yanpeng; Deng, Xilong; Hu, Fengyu; Wang, Jian; Liu, Ying; Huang, Huang; Ma, Jinmin; Zhang, Jianhui; Zhang, Fuchun; Zhang, Chiyu title: Metagenomic analysis identified co-infection with human rhinovirus C and bocavirus 1 in an adult suffering from severe pneumonia date: 2017-10-31 journal: J Infect DOI: 10.1016/j.jinf.2017.10.012 sha: doc_id: 321989 cord_uid: 1enjopig file: cache/cord-328795-rs1sd42z.json key: cord-328795-rs1sd42z authors: Falsey, Ann R.; Branche, Angela R. title: Rhinoviruses date: 2016-10-24 journal: International Encyclopedia of Public Health DOI: 10.1016/b978-0-12-803678-5.00386-6 sha: doc_id: 328795 cord_uid: rs1sd42z file: cache/cord-333261-knj2rrut.json key: cord-333261-knj2rrut authors: Albright, Catherine J.; Hall, David J. title: An exercise in molecular epidemiology: Human rhinovirus prevalence and genetics date: 2011-11-11 journal: Biochem Mol Biol Educ DOI: 10.1002/bmb.20530 sha: doc_id: 333261 cord_uid: knj2rrut file: cache/cord-336713-if6f58ii.json key: cord-336713-if6f58ii authors: Yuan, Lijuan; Geyer, Annelize; Saif, Linda J title: Short-term immunoglobulin A B-cell memory resides in intestinal lymphoid tissues but not in bone marrow of gnotobiotic pigs inoculated with Wa human rotavirus date: 2001-06-01 journal: Immunology DOI: 10.1046/j.1365-2567.2001.01229.x sha: doc_id: 336713 cord_uid: if6f58ii file: cache/cord-346253-0mnsm6s4.json key: cord-346253-0mnsm6s4 authors: Ahanchian, Hamid; Jones, Carmen M; Chen, Yueh-sheng; Sly, Peter D title: Respiratory viral infections in children with asthma: do they matter and can we prevent them? date: 2012-09-13 journal: BMC Pediatr DOI: 10.1186/1471-2431-12-147 sha: doc_id: 346253 cord_uid: 0mnsm6s4 file: cache/cord-342993-deuytbml.json key: cord-342993-deuytbml authors: Maffey, Alberto F.; Barrero, Paola R.; Venialgo, Carolina; Fernández, Francisco; Fuse, Valentina A.; Saia, Mariana; Villalba, Analía; Rodríguez Fermepin, Marcelo; Teper, Alejandro M.; Mistchenko, Alicia S. title: Viruses and atypical bacteria associated with asthma exacerbations in hospitalized children date: 2010-05-06 journal: Pediatr Pulmonol DOI: 10.1002/ppul.21236 sha: doc_id: 342993 cord_uid: deuytbml file: cache/cord-345817-rrf3dbnb.json key: cord-345817-rrf3dbnb authors: WOOD, Lisa G.; POWELL, Heather; GRISSELL, Terry V.; DAVIES, Bronwyn; SHAFREN, Darren R.; WHITEHEAD, Bruce F.; HENSLEY, Michael J.; GIBSON, Peter G. title: Persistence of rhinovirus RNA and IP‐10 gene expression after acute asthma date: 2011-01-27 journal: Respirology DOI: 10.1111/j.1440-1843.2010.01897.x sha: doc_id: 345817 cord_uid: rrf3dbnb file: cache/cord-351571-gwtkrt5u.json key: cord-351571-gwtkrt5u authors: Mackay, Ian M.; Lambert, Stephen B.; Faux, Cassandra E.; Arden, Katherine E.; Nissen, Michael D.; Sloots, Theo P.; Nolan, Terence M. title: Community-Wide, Contemporaneous Circulation of a Broad Spectrum of Human Rhinoviruses in Healthy Australian Preschool-Aged Children During a 12-Month Period date: 2013-05-01 journal: J Infect Dis DOI: 10.1093/infdis/jis476 sha: doc_id: 351571 cord_uid: gwtkrt5u file: cache/cord-352273-sras8r5z.json key: cord-352273-sras8r5z authors: Saraya, Takeshi; Kimura, Hirokazu; Kurai, Daisuke; Ishii, Haruyuki; Takizawa, Hajime title: The molecular epidemiology of respiratory viruses associated with asthma attacks: A single-center observational study in Japan date: 2017-10-20 journal: Medicine (Baltimore) DOI: 10.1097/md.0000000000008204 sha: doc_id: 352273 cord_uid: sras8r5z file: cache/cord-354011-v9t2b2ca.json key: cord-354011-v9t2b2ca authors: Benkouiten, Samir; Charrel, Rémi; Belhouchat, Khadidja; Drali, Tassadit; Salez, Nicolas; Nougairede, Antoine; Zandotti, Christine; Memish, Ziad A.; al Masri, Malak; Gaillard, Catherine; Parola, Philippe; Brouqui, Philippe; Gautret, Philippe title: Circulation of Respiratory Viruses Among Pilgrims During the 2012 Hajj Pilgrimage date: 2013-10-01 journal: Clin Infect Dis DOI: 10.1093/cid/cit446 sha: doc_id: 354011 cord_uid: v9t2b2ca file: cache/cord-356027-ckdx56j1.json key: cord-356027-ckdx56j1 authors: Zheng, Shou-Yan; Xiao, Qiu-Yan; Xie, Xiao-Hong; Deng, Yu; Ren, Luo; Tian, Dai-Yin; Luo, Zheng-Xiu; Luo, Jian; Fu, Zhou; Huang, Ai-Long; Liu, En-Mei title: Association between secondary thrombocytosis and viral respiratory tract infections in children date: 2016-03-11 journal: Sci Rep DOI: 10.1038/srep22964 sha: doc_id: 356027 cord_uid: ckdx56j1 Reading metadata file and updating bibliogrpahics === updating bibliographic database Building study carrel named keyword-hrv-cord === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53368 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53146 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52842 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52820 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52905 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52850 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53460 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54534 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53028 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52913 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53073 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52930 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53060 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53454 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53664 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53349 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53682 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53807 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52795 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52801 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55762 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54362 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52966 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53251 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53303 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52971 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53150 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54541 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55595 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53469 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54346 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53283 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53510 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53933 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 52963 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54626 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54699 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54063 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54220 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54461 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55138 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54566 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55494 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55804 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54385 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55678 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55749 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 53604 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55876 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54092 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55378 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 54237 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55219 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55868 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55460 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55508 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55646 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55459 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === OMP: Error #34: System unable to allocate necessary resources for OMP thread: OMP: System error #11: Resource temporarily unavailable OMP: Hint Try decreasing the value of OMP_NUM_THREADS. /data-disk/reader-compute/reader-cord/bin/file2bib.sh: line 39: 55806 Aborted $FILE2BIB "$FILE" > "$OUTPUT" === file2bib.sh === id: cord-291238-myjyw8ei author: Longtin, Jean title: Rhinovirus Outbreaks in Long-term Care Facilities, Ontario, Canada date: 2010-09-17 pages: extension: .txt txt: ./txt/cord-291238-myjyw8ei.txt cache: ./cache/cord-291238-myjyw8ei.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-291238-myjyw8ei.txt' === file2bib.sh === id: cord-318016-987w5i6t author: de Almeida, Marina B. title: Rhinovirus C and Respiratory Exacerbations in Children with Cystic Fibrosis date: 2010-06-17 pages: extension: .txt txt: ./txt/cord-318016-987w5i6t.txt cache: ./cache/cord-318016-987w5i6t.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-318016-987w5i6t.txt' === file2bib.sh === id: cord-268093-ta6k0uyz author: Etemadi, Mohammad Reza title: Biodiversity and clinico-demographic characteristics of human rhinoviruses from hospitalized children with acute lower respiratory tract infections in Malaysia() date: 2013-08-07 pages: extension: .txt txt: ./txt/cord-268093-ta6k0uyz.txt cache: ./cache/cord-268093-ta6k0uyz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-268093-ta6k0uyz.txt' === file2bib.sh === id: cord-272125-dez1nzg4 author: Jartti, T. title: Allergic sensitization is associated with rhinovirus‐, but not other virus‐, induced wheezing in children date: 2010-10-26 pages: extension: .txt txt: ./txt/cord-272125-dez1nzg4.txt cache: ./cache/cord-272125-dez1nzg4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-272125-dez1nzg4.txt' === file2bib.sh === id: cord-009922-t1hoox6e author: Dearden, C. J. title: Direct detection of rhinoviruses by an enzyme‐linked immunosorbent assay date: 2005-12-07 pages: extension: .txt txt: ./txt/cord-009922-t1hoox6e.txt cache: ./cache/cord-009922-t1hoox6e.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-009922-t1hoox6e.txt' === file2bib.sh === id: cord-005392-0pgcfk6b author: Sidoti, Francesca title: Development of a Quantitative Real-Time Nucleic Acid Sequence-Based Amplification Assay with an Internal Control Using Molecular Beacon Probes for Selective and Sensitive Detection of Human Rhinovirus Serotypes date: 2011-07-05 pages: extension: .txt txt: ./txt/cord-005392-0pgcfk6b.txt cache: ./cache/cord-005392-0pgcfk6b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-005392-0pgcfk6b.txt' === file2bib.sh === id: cord-000374-gt2pwc9b author: Yang, Albert C. title: Clustering Heart Rate Dynamics Is Associated with β-Adrenergic Receptor Polymorphisms: Analysis by Information-Based Similarity Index date: 2011-05-04 pages: extension: .txt txt: ./txt/cord-000374-gt2pwc9b.txt cache: ./cache/cord-000374-gt2pwc9b.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-000374-gt2pwc9b.txt' === file2bib.sh === id: cord-327701-1qgaxcqq author: Scott, E. M. title: Risk factors and patterns of household clusters of respiratory viruses in rural Nepal date: 2019-10-14 pages: extension: .txt txt: ./txt/cord-327701-1qgaxcqq.txt cache: ./cache/cord-327701-1qgaxcqq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-327701-1qgaxcqq.txt' === file2bib.sh === id: cord-327344-8gi1wb76 author: Gambarino, Stefano title: Development of a RT Real-Time PCR for the Detection and Quantification of Human Rhinoviruses date: 2009-03-17 pages: extension: .txt txt: ./txt/cord-327344-8gi1wb76.txt cache: ./cache/cord-327344-8gi1wb76.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-327344-8gi1wb76.txt' === file2bib.sh === id: cord-001601-tsuz3j40 author: Ngan, Luong Thi My title: Antiviral Activity and Possible Mechanism of Action of Constituents Identified in Paeonia lactiflora Root toward Human Rhinoviruses date: 2015-04-10 pages: extension: .txt txt: ./txt/cord-001601-tsuz3j40.txt cache: ./cache/cord-001601-tsuz3j40.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-001601-tsuz3j40.txt' === file2bib.sh === id: cord-336713-if6f58ii author: Yuan, Lijuan title: Short-term immunoglobulin A B-cell memory resides in intestinal lymphoid tissues but not in bone marrow of gnotobiotic pigs inoculated with Wa human rotavirus date: 2001-06-01 pages: extension: .txt txt: ./txt/cord-336713-if6f58ii.txt cache: ./cache/cord-336713-if6f58ii.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-336713-if6f58ii.txt' === file2bib.sh === id: cord-346253-0mnsm6s4 author: Ahanchian, Hamid title: Respiratory viral infections in children with asthma: do they matter and can we prevent them? date: 2012-09-13 pages: extension: .txt txt: ./txt/cord-346253-0mnsm6s4.txt cache: ./cache/cord-346253-0mnsm6s4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 2 resourceName b'cord-346253-0mnsm6s4.txt' === file2bib.sh === id: cord-022084-hap7flng author: ARRUDA, EURICO title: Respiratory Tract Viral Infections date: 2009-05-15 pages: extension: .txt txt: ./txt/cord-022084-hap7flng.txt cache: ./cache/cord-022084-hap7flng.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-022084-hap7flng.txt' === file2bib.sh === id: cord-270892-ycc3csyh author: Rollinger, Judith M. title: The human rhinovirus: human‐pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery date: 2010-12-13 pages: extension: .txt txt: ./txt/cord-270892-ycc3csyh.txt cache: ./cache/cord-270892-ycc3csyh.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 4 resourceName b'cord-270892-ycc3csyh.txt' === file2bib.sh === id: cord-016499-5iqpl23p author: Mackay, Ian M. title: Rhinoviruses date: 2014-02-27 pages: extension: .txt txt: ./txt/cord-016499-5iqpl23p.txt cache: ./cache/cord-016499-5iqpl23p.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-016499-5iqpl23p.txt' === file2bib.sh === id: cord-023302-p9pxz44a author: nan title: Cystic Fibrosis SIG: Poster Session date: 2011-03-21 pages: extension: .txt txt: ./txt/cord-023302-p9pxz44a.txt cache: ./cache/cord-023302-p9pxz44a.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-023302-p9pxz44a.txt' === file2bib.sh === id: cord-023713-daz2vokz author: Devereux, Graham title: Epidemiology of Asthma and Allergic Airway Diseases date: 2013-09-06 pages: extension: .txt txt: ./txt/cord-023713-daz2vokz.txt cache: ./cache/cord-023713-daz2vokz.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 3 resourceName b'cord-023713-daz2vokz.txt' === file2bib.sh === id: cord-023305-5lb9kho6 author: nan title: Oliv SIG: Poster Session date: 2011-03-21 pages: extension: .txt txt: ./txt/cord-023305-5lb9kho6.txt cache: ./cache/cord-023305-5lb9kho6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-023305-5lb9kho6.txt' === file2bib.sh === id: cord-023333-b7w9zrl6 author: nan title: Oeld/Population Health SIG: Poster Session date: 2011-03-21 pages: extension: .txt txt: ./txt/cord-023333-b7w9zrl6.txt cache: ./cache/cord-023333-b7w9zrl6.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-023333-b7w9zrl6.txt' === file2bib.sh === id: cord-023314-rwjxk8v4 author: nan title: Asthma & Allergy SIG: Poster Session 1 date: 2011-03-21 pages: extension: .txt txt: ./txt/cord-023314-rwjxk8v4.txt cache: ./cache/cord-023314-rwjxk8v4.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-023314-rwjxk8v4.txt' === file2bib.sh === id: cord-023298-ysur3sjq author: nan title: Respiratory Nurses SIG: Poster Session date: 2011-03-21 pages: extension: .txt txt: ./txt/cord-023298-ysur3sjq.txt cache: ./cache/cord-023298-ysur3sjq.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-023298-ysur3sjq.txt' === file2bib.sh === id: cord-023343-y17z9w2x author: nan title: COPD SIG: Poster Session 1 date: 2011-03-21 pages: extension: .txt txt: ./txt/cord-023343-y17z9w2x.txt cache: ./cache/cord-023343-y17z9w2x.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 6 resourceName b'cord-023343-y17z9w2x.txt' === file2bib.sh === id: cord-010075-72jodunj author: nan title: Paediatric SIG: Poster Session date: 2011-03-21 pages: extension: .txt txt: ./txt/cord-010075-72jodunj.txt cache: ./cache/cord-010075-72jodunj.txt Content-Encoding UTF-8 Content-Type text/plain; charset=UTF-8 X-Parsed-By ['org.apache.tika.parser.DefaultParser', 'org.apache.tika.parser.csv.TextAndCSVParser'] X-TIKA:content_handler ToTextContentHandler X-TIKA:embedded_depth 0 X-TIKA:parse_time_millis 5 resourceName b'cord-010075-72jodunj.txt' Que is empty; done keyword-hrv-cord === reduce.pl bib === id = cord-001601-tsuz3j40 author = Ngan, Luong Thi My title = Antiviral Activity and Possible Mechanism of Action of Constituents Identified in Paeonia lactiflora Root toward Human Rhinoviruses date = 2015-04-10 pages = extension = .txt mime = text/plain words = 6157 sentences = 328 flesch = 53 summary = An assessment was made of the antiviral activities and mechanisms of action of paeonol (PA) and 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG) from Paeonia lactiflora root toward HRV-2 and HRV-4 in MRC5 cells using a tetrazolium method and real-time quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay. These findings suggest that PGG and PA may block or reduce the entry of the viruses into the cells to protect the cells from the virus destruction and abate virus replication, which may play an important role in interfering with expressions of rhinovirus receptors (intercellular adhesion molecule-1 and low-density lipoprotein receptor), inflammatory cytokines (interleukin (IL)-6, IL-8, tumor necrosis factor, interferon beta, and IL-1β), and Toll-like receptor, which resulted in diminishing symptoms induced by HRV. In the presence of 100 μg/mL PA or 20 μg/mL PGG in MRC5 cell cultures infected with HRV-2, the RNA replication levels were reduced by 30.1 and 14.3 fold, respectively, compared to the levels in the cell cultures without the compounds (Fig 4A) . cache = ./cache/cord-001601-tsuz3j40.txt txt = ./txt/cord-001601-tsuz3j40.txt === reduce.pl bib === id = cord-000374-gt2pwc9b author = Yang, Albert C. title = Clustering Heart Rate Dynamics Is Associated with β-Adrenergic Receptor Polymorphisms: Analysis by Information-Based Similarity Index date = 2011-05-04 pages = extension = .txt mime = text/plain words = 5304 sentences = 279 flesch = 43 summary = With these considerations in mind, in the present study, we introduce a bottom-up genotype-phenotype analysis to investigate the association between genetic polymorphisms and autonomic control of heart rate dynamics, using three common polymorphisms in genes encoding b-adrenergic receptor (b-AR) as an example. The analyses of the present study were two-fold: 1) a nonrandomness index [17] derived from the IBS method was applied to quantify the nonlinear aspect of HRV according to b-AR genotype and to test the correlation of this index with standard HRV indices; and 2) using agglomerative hierarchical cluster analysis, we unsupervisedly categorized these subjects into clusters based on pairwise dissimilarity among heart rate dynamics, and then we investigated the association of these clustering patterns with b-AR gene polymorphisms. The data presented in this study demonstrate a significant association of a common b 2 -AR polymorphism, Arg16Gly, with the non-randomness index, a nonlinear HRV measure derived from the IBS method. cache = ./cache/cord-000374-gt2pwc9b.txt txt = ./txt/cord-000374-gt2pwc9b.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-009922-t1hoox6e author = Dearden, C. J. title = Direct detection of rhinoviruses by an enzyme‐linked immunosorbent assay date = 2005-12-07 pages = extension = .txt mime = text/plain words = 4065 sentences = 205 flesch = 55 summary = This paper describes the first enzyme‐linked immunosorbent assay for the detection of rhinovirus antigens in clinical specimens (nasal washings), either directly or following overnight cell culture amplification. Secondly, a direct ELISA system was developed in which the nasal washings or control antigen (uninfected tissue culture fluid) were added directly to each of a set of duplicate ELISA plate wells coated with either pre-or postchallenge rabbit anti HRV-EL hyperimmune serum. Figure 2 shows the results obtained with nasal washings, collected from three volunteers on consecutive days following HKV-EL or saline challenge, tested in both the cell-culture-amplified (CCA)-ELISA and direct ELISA systems. Although we would like to emphasise that our data are preliminary, both the direct and CCA-ELISAs gave a good correlation with virus isolation when used to detect rhinovirus antigens in nasal washings (obtained from 18 volunteers challenged with either HRV-EL or saline). cache = ./cache/cord-009922-t1hoox6e.txt txt = ./txt/cord-009922-t1hoox6e.txt === reduce.pl bib === === reduce.pl bib === id = cord-005392-0pgcfk6b author = Sidoti, Francesca title = Development of a Quantitative Real-Time Nucleic Acid Sequence-Based Amplification Assay with an Internal Control Using Molecular Beacon Probes for Selective and Sensitive Detection of Human Rhinovirus Serotypes date = 2011-07-05 pages = extension = .txt mime = text/plain words = 3621 sentences = 167 flesch = 41 summary = title: Development of a Quantitative Real-Time Nucleic Acid Sequence-Based Amplification Assay with an Internal Control Using Molecular Beacon Probes for Selective and Sensitive Detection of Human Rhinovirus Serotypes In this study, we developed the first quantitative real-time nucleic acid sequence-based amplification assay with an internal control using molecular beacon probes for selective and sensitive detection of human rhinovirus serotypes. Aim of this study was to develop the first quantitative real-time nucleic acid sequence-based amplification assay internally controlled using molecular beacon for selective and sensitive detection of HRV serotypes. To estimate the dynamic range of the real-time NASBA assay (range of concentrations over which the method performs in a linear manner with an acceptable level of trueness and precision), we used HRV standard dilutions from 10 8 copies/ll to 1 copy/ll. Evaluation of a real-time nucleic acid sequence-based amplification assay using molecular beacons for detection of human immunodeficiency virus type 1 cache = ./cache/cord-005392-0pgcfk6b.txt txt = ./txt/cord-005392-0pgcfk6b.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-272125-dez1nzg4 author = Jartti, T. title = Allergic sensitization is associated with rhinovirus‐, but not other virus‐, induced wheezing in children date = 2010-10-26 pages = extension = .txt mime = text/plain words = 3679 sentences = 208 flesch = 48 summary = A specific immunoglobulin E (IgE) sensitization for common food and aeroallergens and other atopy‐related variables including total IgE, blood and nasal eosinophils, exhaled nitric oxide, eczema and atopic eczema, parental allergy and asthma, number of wheezing episodes, positive asthma predictive index or asthma and use of inhaled corticosteroid were correlated with specific viral etiology. The number of sensitizations was particularly associated with sole rhinovirus etiology (odds ratio 4.59; 95% confidence interval 1.78, 11.8; adjusted to age and sex), followed by aeroallergen sensitization (respectively; 4.18; 2.00, 8.72), total IgE level (2.06; 1.32, 3.21), food allergen sensitization (2.02; 1.08, 3.78), and nasal eosinophil count (1.52; 1.08, 2.13). Log 10 Number of sensitizations were particularly associated with sole HRV etiology (odds ratio 4.59; adjusted to age and sex), followed by aeroallergen sensitization (respectively, 4.18), total IgE level (2.06), food allergen sensitization (2.02), and nasal eosinophil count (1.52) (p < 0.05 for all, Fig. 1b , Table S2 ). cache = ./cache/cord-272125-dez1nzg4.txt txt = ./txt/cord-272125-dez1nzg4.txt === reduce.pl bib === === reduce.pl bib === id = cord-023298-ysur3sjq author = nan title = Respiratory Nurses SIG: Poster Session date = 2011-03-21 pages = extension = .txt mime = text/plain words = 32008 sentences = 1914 flesch = 56 summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. cache = ./cache/cord-023298-ysur3sjq.txt txt = ./txt/cord-023298-ysur3sjq.txt === reduce.pl bib === id = cord-268093-ta6k0uyz author = Etemadi, Mohammad Reza title = Biodiversity and clinico-demographic characteristics of human rhinoviruses from hospitalized children with acute lower respiratory tract infections in Malaysia() date = 2013-08-07 pages = extension = .txt mime = text/plain words = 3354 sentences = 173 flesch = 50 summary = The presence of the new HRV-C strain in severe respiratory disease has further instilled research interest in the clinical impact, molecular biology and epidemiology of HRVs. As research of HRV is limited [8] , especially in Asian developing countries, this study aims to examine the molecular epidemiology, the demographic characteristics and clinical features including the newly discovered HRV-C species, among hospitalized children less than 5 years of age with ALRTI in Malaysia. HRV infected patients were admitted earlier compared to RSV and influenza; children with HRV presented to the hospital after a mean duration of 1.9 days (ranged 1-9 days) as compared with HRV (4.0 days, p = <0.001) and IFV-A (4.8 days, p = 0.002). Our study revealed that HRV infected children were hospitalized earlier in the course of their disease and were less febrile on presentation as compared to RSV and IFV-A infections. cache = ./cache/cord-268093-ta6k0uyz.txt txt = ./txt/cord-268093-ta6k0uyz.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-023713-daz2vokz author = Devereux, Graham title = Epidemiology of Asthma and Allergic Airway Diseases date = 2013-09-06 pages = extension = .txt mime = text/plain words = 27880 sentences = 1480 flesch = 51 summary = A systematic review and metaanalysis of the longitudinal studies relating maternal vitamin D status during pregnancy to childhood outcomes concluded that high maternal dietary vitamin D intake is associated with a reduced risk of children wheezing up to the age of 5 years (OR = 0.56; 95% CI, 0.42 to 0.73). The Dutch Prevention and Incidence of Asthma and Mite allergy (PIAMA) birth cohort study related symptom data prospectively collected annually from 3863 children up to the age of 8 years to land-use regression estimates of individual NO 2 , PM 2.5 , and soot exposures at their birth addresses. 327 A systematic review and meta-analysis of prospective birth cohort studies evaluating the effects of allergen (i.e., HDM or dietary) avoidance during pregnancy concluded that early-life allergen avoidance in isolation does not reduce the likelihood of asthma in children at age 5 years (OR = 1.22; 95% CI, 0.83 to 1.78). cache = ./cache/cord-023713-daz2vokz.txt txt = ./txt/cord-023713-daz2vokz.txt === reduce.pl bib === === reduce.pl bib === id = cord-291238-myjyw8ei author = Longtin, Jean title = Rhinovirus Outbreaks in Long-term Care Facilities, Ontario, Canada date = 2010-09-17 pages = extension = .txt mime = text/plain words = 1635 sentences = 94 flesch = 51 summary = Although the most commonly identifi ed viruses have been infl uenza virus and respiratory syncytial virus (RSV) (1), human rhinovirus (HRV) is being increasingly associated with severe respiratory disease and outbreaks in these facilities (2) (3) (4) (5) (6) . As a result, the number of outbreaks caused by HRV in long-term care facilities, and the associated illness and death, may be substantially underestimated. During the surveillance period, 297 respiratory disease outbreaks in long-term care facilities were reported to the Ontario Public Health Laboratory; we received samples from 269 facilities (Table 1) . We cautiously assume that HRV was the causative organism for 174 (59%) of the 297 respiratory outbreaks in long-term care facilities in Ontario during the surveillance period. Neighbor-joining phylogenetic tree of human rhinoviruses (HRV) isolated from 4 respiratory disease outbreaks with associated deaths in long-term care facilities, Ontario, Canada. cache = ./cache/cord-291238-myjyw8ei.txt txt = ./txt/cord-291238-myjyw8ei.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-010075-72jodunj author = nan title = Paediatric SIG: Poster Session date = 2011-03-21 pages = extension = .txt mime = text/plain words = 32008 sentences = 1913 flesch = 56 summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. cache = ./cache/cord-010075-72jodunj.txt txt = ./txt/cord-010075-72jodunj.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-023305-5lb9kho6 author = nan title = Oliv SIG: Poster Session date = 2011-03-21 pages = extension = .txt mime = text/plain words = 32008 sentences = 1916 flesch = 56 summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. cache = ./cache/cord-023305-5lb9kho6.txt txt = ./txt/cord-023305-5lb9kho6.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-016499-5iqpl23p author = Mackay, Ian M. title = Rhinoviruses date = 2014-02-27 pages = extension = .txt mime = text/plain words = 23394 sentences = 1156 flesch = 45 summary = A convenience population of 15 healthy children (1-9 years old) without asthma were followed during at least three seasons, and picornaviruses were detected in 5 % of 740 specimens (21 % of infections) not associated with symptoms, The impact of HRV typing and of sampling based only on symptoms. Clinical features and complete genome characterization of a distinct human rhinovirus genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children Comparison of results of detection of rhinovirus by PCR and viral culture in human nasal wash specimens from subjects with and without clinical symptoms of respiratory illness Detection of human rhinovirus C viral genome in blood among children with severe respiratory infections in the Philippines cache = ./cache/cord-016499-5iqpl23p.txt txt = ./txt/cord-016499-5iqpl23p.txt === reduce.pl bib === id = cord-270892-ycc3csyh author = Rollinger, Judith M. title = The human rhinovirus: human‐pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery date = 2010-12-13 pages = extension = .txt mime = text/plain words = 19628 sentences = 1166 flesch = 41 summary = [79] [80] [81] [82] Taken together, the results of natural cold studies as well as of experimental infection in human volunteers clearly demonstrate that HRV are able to replicate in the upper as well as in the lower airways. Such an anti-HRV drug would have to be (i) with broad spectrum activity because of the high number of HRV serotypes, (ii) administered very early in infection to demonstrate a good antiviral effect because of the fast infection kinetics, (iii) very safe because of the broad application by millions of people, and (iv) directed against a highly conserved target with low risk of resistance development. The HRV-induced CPE, infectious virus titers, viral protein expression, and RNA synthesis can be chosen as parameters to evaluate the anti-HRV activity of compounds in cell-culture based assays. Due to the lack of a small-animal model for HRV infection until 2008, the experimental human challenge model has to be used to approve effects of potential antiviral drugs under controlled conditions in preclinical studies. cache = ./cache/cord-270892-ycc3csyh.txt txt = ./txt/cord-270892-ycc3csyh.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-023302-p9pxz44a author = nan title = Cystic Fibrosis SIG: Poster Session date = 2011-03-21 pages = extension = .txt mime = text/plain words = 32008 sentences = 1915 flesch = 56 summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. cache = ./cache/cord-023302-p9pxz44a.txt txt = ./txt/cord-023302-p9pxz44a.txt === reduce.pl bib === id = cord-023314-rwjxk8v4 author = nan title = Asthma & Allergy SIG: Poster Session 1 date = 2011-03-21 pages = extension = .txt mime = text/plain words = 32009 sentences = 1912 flesch = 56 summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. cache = ./cache/cord-023314-rwjxk8v4.txt txt = ./txt/cord-023314-rwjxk8v4.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-327344-8gi1wb76 author = Gambarino, Stefano title = Development of a RT Real-Time PCR for the Detection and Quantification of Human Rhinoviruses date = 2009-03-17 pages = extension = .txt mime = text/plain words = 3506 sentences = 147 flesch = 38 summary = This article describes the development and optimization of a reverse transcription (RT) real-time PCR assay for quantification of HRV RNA in clinical samples. Clinical specimens originated from the Virology Unit of the Fig. 1 Standard curve (from 10 2 to 10 5 copies/reaction) and dynamic range (from 10 7 to 10 1 copies/reaction) of the real-time RT-PCR developed in this study Azienda Ospedaliero-Universitaria San Giovanni Battista, Turin, and included 110 bronchoalveolar lavages (BAL) obtained from 84 patients (M/F, 57/27; mean age, 57.8 years; range, . The performance of the RT real-time PCR developed in this study was examined over different concentrations of HRV RNA and it was found to be very sensitive with a minimum cut-off for detection of 10 0 copy/reaction and was linear up to 10 1 copies. In conclusion, the RT real-time PCR assay developed in this study could represent a useful tool for diagnosing HRV infections, quantifying the viral load and could be applicable for routine diagnostic workup of upper as well as lower respiratory tract diseases. cache = ./cache/cord-327344-8gi1wb76.txt txt = ./txt/cord-327344-8gi1wb76.txt === reduce.pl bib === id = cord-318016-987w5i6t author = de Almeida, Marina B. title = Rhinovirus C and Respiratory Exacerbations in Children with Cystic Fibrosis date = 2010-06-17 pages = extension = .txt mime = text/plain words = 1848 sentences = 101 flesch = 45 summary = To investigate a possible role for human rhinovirus C in respiratory exacerbations of children with cystic fibrosis, we conducted microbiologic testing on respiratory specimens from 103 such patients in São Paulo, Brazil, during 2006–2007. To investigate a possible role for human rhinovirus C in respiratory exacerbations of children with cystic fi brosis, we conducted microbiologic testing on respiratory specimens from 103 such patients in São Paulo, Brazil, during 2006-2007. In the study reported here, we obtained samples from patients during routine visits and exacerbations, which enabled us to identify a distinct role of different HRV subtypes. (3) , in which they used real-time nucleic acid sequence-based amplifi cation in conjunction with molecular markers to investigate the presence of 9 respiratory viruses in children with CF, described an association of viral infections with respiratory exacerbations, particularly those caused by infl uenza A, infl uenza B, and rhinovirus (3). cache = ./cache/cord-318016-987w5i6t.txt txt = ./txt/cord-318016-987w5i6t.txt === reduce.pl bib === === reduce.pl bib === id = cord-023343-y17z9w2x author = nan title = COPD SIG: Poster Session 1 date = 2011-03-21 pages = extension = .txt mime = text/plain words = 32008 sentences = 1910 flesch = 55 summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. cache = ./cache/cord-023343-y17z9w2x.txt txt = ./txt/cord-023343-y17z9w2x.txt === reduce.pl bib === id = cord-327701-1qgaxcqq author = Scott, E. M. title = Risk factors and patterns of household clusters of respiratory viruses in rural Nepal date = 2019-10-14 pages = extension = .txt mime = text/plain words = 4720 sentences = 215 flesch = 42 summary = In a prospective longitudinal study utilizing intensive weekly home-based active surveillance to evaluate the household transmission of nine respiratory viruses in rural South Asia, initial infection in young children was associated with the greatest risk of symptomatic respiratory virus household transmission with spread to infants occurring in 45% of transmission events. A higher proportion of initial infection among this group resulted in secondary cases compared to other age groups, including school-age children and mothers, a finding confirmed in our multivariable model of transmission incidence. While a model of Kenya transmission data supports immunizing school-age children to diminish transmission of the virus to infants, our study suggests that in rural South Asia, preschool-age children are more likely to transmit respiratory viruses to other household members [38] . Our study of non-influenza respiratory virus transmission within households in rural Nepal highlights the importance of targeting preschool-age children to prevent the spread of respiratory viral illness. cache = ./cache/cord-327701-1qgaxcqq.txt txt = ./txt/cord-327701-1qgaxcqq.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-022084-hap7flng author = ARRUDA, EURICO title = Respiratory Tract Viral Infections date = 2009-05-15 pages = extension = .txt mime = text/plain words = 19181 sentences = 1041 flesch = 43 summary = The Centers for Disease Control and Prevention (CDC) recommends the immunization of persons aged 50 years and older; residents of nursing homes; children and adults with chronic cardiovascular or pulmonary disease, including asthma; persons chronically ill with diabetes mellitus, renal dysfunction, or hemoglobinopathies; immunosuppressed patients including those with HIV infection; children and adolescents on chronic aspirin therapy who may develop postinfluenza Reye' s syndrome; women who will be pregnant during the influenza season; children aged 6 to 23 months; those who can transmit influenza to persons at high risk, such as health-care workers and household contacts of those at high risk including children 0 to 23 months of age; crew members of cruise ships; providers of essential services; and unimmunized travelers to areas where influenza may be circulating, including the tropics, the southern hemisphere between April and September, and those traveling in large organized tourist groups. cache = ./cache/cord-022084-hap7flng.txt txt = ./txt/cord-022084-hap7flng.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-023333-b7w9zrl6 author = nan title = Oeld/Population Health SIG: Poster Session date = 2011-03-21 pages = extension = .txt mime = text/plain words = 32009 sentences = 1914 flesch = 56 summary = Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. cache = ./cache/cord-023333-b7w9zrl6.txt txt = ./txt/cord-023333-b7w9zrl6.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-336713-if6f58ii author = Yuan, Lijuan title = Short-term immunoglobulin A B-cell memory resides in intestinal lymphoid tissues but not in bone marrow of gnotobiotic pigs inoculated with Wa human rotavirus date = 2001-06-01 pages = extension = .txt mime = text/plain words = 7543 sentences = 367 flesch = 56 summary = To investigate the development and sites of residence of intestinal memory B cells, and their role in protective immunity to reinfection with an enteric virus, we assessed the association between memory B cell and antibody-secreting cell (ASC) responses and protection using a gnotobiotic pig model for human rotavirus (HRV) infection and diarrhoea. The isotypes, quantities and tissue distribution of rotavirus-specific memory B cells and ASC were evaluated prechallenge (28 and 83 postinoculation days [PID]) and postchallenge (7 postchallenge days [PCD]), using enzyme-linked immunospot (ELISPOT) assay, in gnotobiotic pigs inoculated once with virulent or three times with attenuated HRV and challenged at PID 28 with the corresponding virulent HRV. In previous studies, 3, 4 we reported that the number of rotavirus-speci®c immunoglobulin A (IgA) antibody-secreting cells (ASC) present in the intestinal lamina propria of gnotobiotic pigs at the time of challenge (primary ASC) correlates with protection against infection and diarrhoea when challenged with human rotavirus (HRV). cache = ./cache/cord-336713-if6f58ii.txt txt = ./txt/cord-336713-if6f58ii.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === id = cord-346253-0mnsm6s4 author = Ahanchian, Hamid title = Respiratory viral infections in children with asthma: do they matter and can we prevent them? date = 2012-09-13 pages = extension = .txt mime = text/plain words = 7744 sentences = 399 flesch = 35 summary = HRV are the most common viral agents [33] ; Other respiratory tract viruses detected in children with an asthma exacerbation include RSV, influenza, coronavirus, hMPV, parainfluenza virus, adenovirus, and bocavirus [34] [35] [36] . Beside importance for bone health, vitamin D plays an important role in adequate function of both the innate and adaptive immune systems including development of dendritic cells and regulatory T lymphocytes [151, 152] production of antimicrobial proteins by airway epithelium [153] , modifying the effect of intestinal flora on inflammatory disorders [107] , and modulation of the inflammatory response to viral infections [154] . In a recent study of 48 children from five to 18 years of age, with newly diagnosed asthma, vitamin D supplementation during the northern hemisphere winter months (September to July) prevented declining serum concentrations of 25(OH) D and reduced the risk of asthma exacerbation triggered by acute respiratory tract infections [161] . cache = ./cache/cord-346253-0mnsm6s4.txt txt = ./txt/cord-346253-0mnsm6s4.txt === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === === reduce.pl bib === ===== Reducing email addresses Creating transaction Updating adr table ===== Reducing keywords cord-016783-8x05oh5q cord-001601-tsuz3j40 cord-002257-30s14h9j cord-000374-gt2pwc9b cord-000483-zgapjjjw cord-009922-t1hoox6e cord-009877-3cyz6o9c cord-005392-0pgcfk6b cord-007234-hcpa8ej5 cord-258336-zs04l3s0 cord-004749-wyzb8v4a cord-004694-43yvs52a cord-018421-wy3mtafh cord-023766-qx0qdjmt cord-009773-pbm2vs5h cord-000082-jy7j8sh0 cord-272125-dez1nzg4 cord-023298-ysur3sjq 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cord-000374-gt2pwc9b cord-009922-t1hoox6e cord-000483-zgapjjjw cord-002257-30s14h9j cord-009877-3cyz6o9c cord-005392-0pgcfk6b cord-258336-zs04l3s0 cord-004749-wyzb8v4a cord-007234-hcpa8ej5 cord-018421-wy3mtafh cord-009773-pbm2vs5h cord-004694-43yvs52a cord-023766-qx0qdjmt cord-253564-3y1wdepc cord-000082-jy7j8sh0 cord-272125-dez1nzg4 cord-023713-daz2vokz cord-268093-ta6k0uyz cord-023298-ysur3sjq cord-252347-vnn4135b cord-281158-vjh9z7l4 cord-289358-4abypk6o cord-291238-myjyw8ei cord-015893-e0fofgxq cord-278438-bnjkmegh cord-275275-wy8d6cw3 cord-284875-hsa2r7ns cord-309497-3v0asfa7 cord-010160-wk8k2igu cord-010075-72jodunj cord-307333-n6jc0jy3 cord-319942-ava86u8y cord-023305-5lb9kho6 cord-290773-kgb8r561 cord-314841-b5l6epy3 cord-299537-lbx1plqx cord-307602-2cmgu7rf cord-259997-8f8di4eu cord-016499-5iqpl23p cord-270892-ycc3csyh cord-307990-skrye40w cord-023302-p9pxz44a cord-325137-6c6er06a cord-103367-fxvvndic cord-280391-5kiu2pb6 cord-287063-kheek4lx cord-023314-rwjxk8v4 cord-299672-dq1y1gkc cord-281162-2pu7x5rj cord-310171-1fmsxx2s cord-324216-ce3wa889 cord-316319-m6uha1qn cord-316245-n6tmn4ph cord-317198-mean7sj9 cord-269922-ddpud48b cord-274943-fn3m14cn cord-225218-x32a4sp3 cord-318016-987w5i6t cord-327344-8gi1wb76 cord-327701-1qgaxcqq cord-023343-y17z9w2x cord-291486-5h96msv1 cord-317499-mxt7stat cord-022084-hap7flng cord-317548-ft7lkpzq cord-023333-b7w9zrl6 cord-327610-cm3vkpcn cord-284889-hth8nf5b cord-336713-if6f58ii cord-342993-deuytbml cord-345817-rrf3dbnb cord-321989-1enjopig cord-346253-0mnsm6s4 cord-316932-fia1w9jt cord-333261-knj2rrut cord-328795-rs1sd42z cord-351571-gwtkrt5u cord-352273-sras8r5z cord-354011-v9t2b2ca cord-356027-ckdx56j1 Creating transaction Updating ent table ===== Reducing parts of speech cord-000483-zgapjjjw cord-002257-30s14h9j cord-001601-tsuz3j40 cord-000374-gt2pwc9b cord-016783-8x05oh5q cord-009922-t1hoox6e cord-009877-3cyz6o9c cord-005392-0pgcfk6b cord-007234-hcpa8ej5 cord-004694-43yvs52a cord-009773-pbm2vs5h cord-018421-wy3mtafh cord-004749-wyzb8v4a cord-258336-zs04l3s0 cord-023766-qx0qdjmt cord-000082-jy7j8sh0 cord-272125-dez1nzg4 cord-281158-vjh9z7l4 cord-253564-3y1wdepc cord-252347-vnn4135b cord-268093-ta6k0uyz cord-291238-myjyw8ei cord-289358-4abypk6o cord-010160-wk8k2igu cord-015893-e0fofgxq cord-284875-hsa2r7ns cord-309497-3v0asfa7 cord-319942-ava86u8y cord-275275-wy8d6cw3 cord-290773-kgb8r561 cord-307333-n6jc0jy3 cord-314841-b5l6epy3 cord-307602-2cmgu7rf cord-299537-lbx1plqx cord-259997-8f8di4eu cord-307990-skrye40w cord-278438-bnjkmegh cord-280391-5kiu2pb6 cord-281162-2pu7x5rj cord-023298-ysur3sjq cord-023713-daz2vokz cord-299672-dq1y1gkc cord-287063-kheek4lx cord-010075-72jodunj cord-325137-6c6er06a cord-270892-ycc3csyh cord-103367-fxvvndic cord-310171-1fmsxx2s cord-324216-ce3wa889 cord-317198-mean7sj9 cord-316245-n6tmn4ph cord-316319-m6uha1qn cord-327344-8gi1wb76 cord-016499-5iqpl23p cord-269922-ddpud48b cord-318016-987w5i6t cord-274943-fn3m14cn cord-225218-x32a4sp3 cord-327701-1qgaxcqq cord-291486-5h96msv1 cord-317499-mxt7stat cord-317548-ft7lkpzq cord-023305-5lb9kho6 cord-023314-rwjxk8v4 cord-284889-hth8nf5b cord-327610-cm3vkpcn cord-333261-knj2rrut cord-321989-1enjopig cord-316932-fia1w9jt cord-328795-rs1sd42z cord-351571-gwtkrt5u cord-342993-deuytbml cord-345817-rrf3dbnb cord-023302-p9pxz44a cord-336713-if6f58ii cord-352273-sras8r5z cord-022084-hap7flng cord-356027-ckdx56j1 cord-354011-v9t2b2ca cord-346253-0mnsm6s4 cord-023343-y17z9w2x cord-023333-b7w9zrl6 Creating transaction Updating pos table Building ./etc/reader.txt cord-016499-5iqpl23p cord-022084-hap7flng cord-284889-hth8nf5b cord-270892-ycc3csyh cord-016499-5iqpl23p cord-022084-hap7flng number of items: 82 sum of words: 367,317 average size in words: 15,970 average readability score: 49 nouns: asthma; patients; children; infection; virus; study; infections; viruses; rhinovirus; age; results; cells; years; studies; disease; cell; lung; airway; methods; data; time; subjects; treatment; detection; symptoms; risk; group; samples; analysis; exacerbations; tract; expression; days; influenza; illness; infants; response; use; levels; prevalence; cases; adults; function; rate; groups; role; number; months; strains; control verbs: used; associated; increased; showed; compared; included; detecting; induced; reported; reduce; perform; found; based; followed; determine; identify; suggest; aimed; develop; cause; assessing; required; collected; measured; related; occurs; wheeze; described; infect; obtained; hospitalized; investigate; provide; observed; support; treated; testing; examine; resulting; involve; indicated; present; predict; known; mean; considered; improve; remains; underwent; demonstrated adjectives: respiratory; viral; human; clinical; acute; positive; common; lower; high; severe; non; different; pulmonary; higher; new; molecular; epithelial; low; chronic; specific; mean; similar; antiviral; immune; healthy; syncytial; single; important; significant; early; major; young; upper; asthmatic; normal; negative; small; large; likely; allergic; first; available; stable; diagnostic; bronchial; greater; atopic; several; genetic; novel adverbs: also; however; nt; well; respectively; cantly; previously; often; significantly; frequently; prior; therefore; less; recently; particularly; highly; commonly; clinically; especially; even; currently; mainly; newly; relatively; furthermore; approximately; alone; statistically; later; usually; moreover; least; rather; directly; generally; now; still; similarly; overall; worldwide; almost; yet; strongly; first; potentially; successfully; closely; increasingly; ever; outdoors pronouns: we; it; our; their; they; its; them; i; she; us; themselves; one; itself; his; you; her; my; il-1β; he; ours; your; isg56-mrnas; pteronyssinus; mg; interferon--7; herself; em; cord-252347-vnn4135b proper nouns: HRV; PCR; RSV; COPD; RNA; C; A; signifi; ed; B; fi; CF; IFN; Confl; Fig; FEV; fl; RT; infl; CI; identifi; ARI; ±; Hospital; ASM; Health; Methods; Rhinovirus; Table; M; defi; DI; IgA; D; S; Australia; L; Nil; Asthma; AR; NIV; ned; III; ELISA; Wa; ICC; uenza; H1N1; Human; CT keywords: hrv; pcr; rsv; infection; respiratory; copd; virus; study; rna; patient; cell; airway; result; nil; method; interest; increase; fev; asm; asthma; child; rhinovirus; outbreak; ifn; viral; table; sequence; human; hrv-2; hrsv; hmpv; heart; exacerbation; elisa; asc; ari; year; vp2; visit; virochip; urti; united; turner; subject; states; sop; sirt1; sars; qpm; prevention one topic; one dimension: hrv file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393083/ titles(s): Antiviral Activity and Possible Mechanism of Action of Constituents Identified in Paeonia lactiflora Root toward Human Rhinoviruses three topics; one dimension: hrv; patients; asthma file(s): https://www.ncbi.nlm.nih.gov/pubmed/27822536/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169216/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173512/ titles(s): A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses | Oeld/Population Health SIG: Poster Session | Epidemiology of Asthma and Allergic Airway Diseases five topics; three dimensions: patients results methods; hrv respiratory viruses; asthma children respiratory; hrv cells rhinovirus; subjects hrv atopic file(s): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169216/, https://www.ncbi.nlm.nih.gov/pubmed/27822536/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173512/, https://www.ncbi.nlm.nih.gov/pubmed/11412306/, http://medrxiv.org/cgi/content/short/2020.07.05.20146571v1?rss=1 titles(s): Oeld/Population Health SIG: Poster Session | A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses | Epidemiology of Asthma and Allergic Airway Diseases | Short-term immunoglobulin A B-cell memory resides in intestinal lymphoid tissues but not in bone marrow of gnotobiotic pigs inoculated with Wa human rotavirus | Machine learning dimensionality reduction for heart rate n-variability (HRnV) based risk stratification of chest pain patients in the emergency department Type: cord title: keyword-hrv-cord date: 2021-05-25 time: 00:26 username: emorgan patron: Eric Morgan email: emorgan@nd.edu input: keywords:hrv ==== make-pages.sh htm files ==== make-pages.sh complex files ==== make-pages.sh named enities ==== making bibliographics id: cord-022084-hap7flng author: ARRUDA, EURICO title: Respiratory Tract Viral Infections date: 2009-05-15 words: 19181.0 sentences: 1041.0 pages: flesch: 43.0 cache: ./cache/cord-022084-hap7flng.txt txt: ./txt/cord-022084-hap7flng.txt summary: The Centers for Disease Control and Prevention (CDC) recommends the immunization of persons aged 50 years and older; residents of nursing homes; children and adults with chronic cardiovascular or pulmonary disease, including asthma; persons chronically ill with diabetes mellitus, renal dysfunction, or hemoglobinopathies; immunosuppressed patients including those with HIV infection; children and adolescents on chronic aspirin therapy who may develop postinfluenza Reye'' s syndrome; women who will be pregnant during the influenza season; children aged 6 to 23 months; those who can transmit influenza to persons at high risk, such as health-care workers and household contacts of those at high risk including children 0 to 23 months of age; crew members of cruise ships; providers of essential services; and unimmunized travelers to areas where influenza may be circulating, including the tropics, the southern hemisphere between April and September, and those traveling in large organized tourist groups. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7152450/ doi: 10.1016/b978-0-443-06668-9.50064-8 id: cord-346253-0mnsm6s4 author: Ahanchian, Hamid title: Respiratory viral infections in children with asthma: do they matter and can we prevent them? date: 2012-09-13 words: 7744.0 sentences: 399.0 pages: flesch: 35.0 cache: ./cache/cord-346253-0mnsm6s4.txt txt: ./txt/cord-346253-0mnsm6s4.txt summary: HRV are the most common viral agents [33] ; Other respiratory tract viruses detected in children with an asthma exacerbation include RSV, influenza, coronavirus, hMPV, parainfluenza virus, adenovirus, and bocavirus [34] [35] [36] . Beside importance for bone health, vitamin D plays an important role in adequate function of both the innate and adaptive immune systems including development of dendritic cells and regulatory T lymphocytes [151, 152] production of antimicrobial proteins by airway epithelium [153] , modifying the effect of intestinal flora on inflammatory disorders [107] , and modulation of the inflammatory response to viral infections [154] . In a recent study of 48 children from five to 18 years of age, with newly diagnosed asthma, vitamin D supplementation during the northern hemisphere winter months (September to July) prevented declining serum concentrations of 25(OH) D and reduced the risk of asthma exacerbation triggered by acute respiratory tract infections [161] . abstract: BACKGROUND: Asthma is a major public health problem with a huge social and economic burden affecting 300 million people worldwide. Viral respiratory infections are the major cause of acute asthma exacerbations and may contribute to asthma inception in high risk young children with susceptible genetic background. Acute exacerbations are associated with decreased lung growth or accelerated loss of lung function and, as such, add substantially to both the cost and morbidity associated with asthma. DISCUSSION: While the importance of preventing viral infection is well established, preventive strategies have not been well explored. Good personal hygiene, hand-washing and avoidance of cigarette smoke are likely to reduce respiratory viral infections. Eating a healthy balanced diet, active probiotic supplements and bacterial-derived products, such as OM-85, may reduce recurrent infections in susceptible children. There are no practical anti-viral therapies currently available that are suitable for widespread use. SUMMARY: Hand hygiene is the best measure to prevent the common cold. A healthy balanced diet, active probiotic supplements and immunostimulant OM-85 may reduce recurrent infections in asthmatic children. url: https://doi.org/10.1186/1471-2431-12-147 doi: 10.1186/1471-2431-12-147 id: cord-290773-kgb8r561 author: Ahn, Jong Gyun title: Clinical characteristics and cytokine profiles of children with acute lower respiratory tract infections caused by human rhinovirus date: 2018-07-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The clinical profile of human rhinovirus (HRV) with regard to lower respiratory infections remains unclear. We analyzed the clinical features and cytokine responses of HRV isolates in children with respiratory infections. Quantitative analysis and genotyping of the HRV-positive samples from 601 nasopharyngeal aspirates (NPAs) were performed using VP4/VP2 sequencing. To compare T-helper1 (Th1) type (IFN-γ, TNF-α) and Th2 type (IL-4, IL-10) cytokine responses between HRV-A, B and C, the levels of the four cytokines were measured. The HRV-positive children had shorter fever duration (P = 0.018), and higher frequencies of chest retraction (P = 0.002) and wheezing (P = 0.022) than did the HRV-negative group. HRV-A was identified in 55 cases (58.5%), HRV-B in 8 (8.5%), and HRV-C in 31 (33.0%). There were no significant differences in the clinical data or NPA cytokines levels between patients with HRV-A and HRV-C infections. HRV is an important pathogen of the lower respiratory tract in young children. HRV-A and HRV-C are the dominant species that cause respiratory difficulty in young children. url: https://www.ncbi.nlm.nih.gov/pubmed/29969445/ doi: 10.1371/journal.pone.0198624 id: cord-280391-5kiu2pb6 author: Akinloye, Oluwabukola M. title: Specific Viruses Detected in Nigerian Children in Association with Acute Respiratory Disease date: 2011-10-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Occurrence of different viruses in acute respiratory tract infections of Nigerian children was examined. Respiratory swabs were collected from 246 children referred to hospital clinics because of acute respiratory symptoms from February through May 2009. Validated real-time RT-PCR techniques revealed nucleic acids of at least one virus group in 189 specimens (77%). Human rhinoviruses and parainfluenza viruses were present each in one third of the children. Adenoviruses, enteroviruses, human metapneumovirus, human bocavirus, and influenza C virus were also relatively common. Possibly due to their seasonal occurrence, influenza A and B virus, and respiratory syncytial virus were detected rarely. We conclude that all major groups of respiratory tract viruses are causing illness in Nigerian children. url: https://www.ncbi.nlm.nih.gov/pubmed/22007241/ doi: 10.1155/2011/690286 id: cord-333261-knj2rrut author: Albright, Catherine J. title: An exercise in molecular epidemiology: Human rhinovirus prevalence and genetics date: 2011-11-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Human rhinovirus (HRV) is one of the most common human respiratory pathogens and is responsible for the majority of upper respiratory illnesses. Recently, a phylogeny was constructed from all known American Type Culture Collection (ATCC) HRV sequences. From this study, three HRV classifications (HRVA, HRVB, and HRVC) were determined and techniques for classifying new isolates of HRV were reported. The genetic change of this virus in specific populations over time is of great interest to understand the evolution and epidemiology of viruses. To facilitate the collections of HRV sequences over a number of years, a virology experiment was designed in which students test nasal lavage samples to look for HRV infection. Students will learn a variety of techniques including RNA isolation, cDNA synthesis, qPCR, and agarose gel electrophoresis as well as bioinformatic skills though examination of sequences from the HRV‐field isolates. Furthermore, students can look at symptom data from subjects to investigate correlations between symptom severity and factors such as stress and sleep patterns. Such information can be used to examine hypotheses regarding HRV mutation, symptom severity and epidemiology. BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION Vol. 39, No. 6, pp. 457–458, 2011 url: https://doi.org/10.1002/bmb.20530 doi: 10.1002/bmb.20530 id: cord-016783-8x05oh5q author: Arruda, L. Karla title: Early Interventions in Allergic Diseases date: 2010 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Atopy has been defined as the genetic predisposition to develop IgE antibody responses to a variety of common environmental allergens. Clinically, atopy is expressed by asthma, allergic rhinoconjunctivitis and atopic dermatitis. It has been recognized that the “atopic march” evolves from food allergy and atopic dermatitis in the first 2 years of life, followed by asthma and allergic rhinitis. Over the past 30 years, the prevalence of allergies and asthma has increased significantly in developed countries, and asthma is one of the most common chronic diseases in children. Evidence indicates that environmental factors acting early in life, including respiratory viral infections, exposure to pets and microbial products, day-care attendance, breast feeding, and exposure to allergens, tobacco smoke and other pollutants, are key events for establishment of sensitization and development of chronic, persistent symptoms of allergic diseases [1]. It is thought that gene—environment interactions play a crucial role in these processes. Therefore, attempts to successfully prevent development of allergic diseases should be a priority. At present, there are no genetic markers for atopy or asthma which could be used routinely in clinical practice and family history of atopy has been used to identify children genetically at-risk of developing allergic diseases. These children from high-risk families have been the focus of most of the intervention studies. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121172/ doi: 10.1007/978-4-431-99362-9_23 id: cord-309497-3v0asfa7 author: Asner, Sandra title: Respiratory viral infections in institutions from late stage of the first and second waves of pandemic influenza A (H1N1) 2009, Ontario, Canada date: 2012-02-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Please cite this paper as: Asner et al. (2012) Respiratory viral infections in institutions from late stage of the first and second waves of pandemic A (H1N1) 2009, Ontario, Canada. Influenza and Other Respiratory Viruses 6(3), e11–e15. We report the impact of respiratory viruses on various outbreak settings by using surveillance data from the late first and second wave periods of the 2009 pandemic. A total of 278/345(78·5%) outbreaks tested positive for at least one respiratory virus by multiplex PCR. We detected A(H1N1)pdm09 in 20·6% of all reported outbreaks of which 54·9% were reported by camps, schools, and day cares (CSDs) and 29·6% by long‐term care facilities (LCFTs), whereas enterovirus/human rhinovirus (ENT/HRV) accounted for 62% outbreaks of which 83·7% were reported by long‐term care facilities (LCTFs). ENT/HRV was frequently identified in LTCF outbreaks involving elderly residents, whereas in CSDs, A(H1N1)pdm09 was primarily detected. url: https://www.ncbi.nlm.nih.gov/pubmed/22353417/ doi: 10.1111/j.1750-2659.2012.00336.x id: cord-289358-4abypk6o author: Asner, Sandra A. title: Clinical severity of rhinovirus/enterovirus compared to other respiratory viruses in children date: 2014-05-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Human rhinovirus/enterovirus (HRV/ENT) infections are commonly identified in children with acute respiratory infections (ARIs), but data on their clinical severity remain limited. OBJECTIVES: We compared the clinical severity of HRV/ENT to respiratory syncytial virus (RSV), influenza A/B (FLU), and other common respiratory viruses in children. PATIENTS/METHODS: Retrospective study of children with ARIs and confirmed single positive viral infections on mid‐turbinate swabs by molecular assays. Outcome measures included hospital admission and, for inpatients, a composite endpoint consisting of intensive care admission, hospitalization >5 days, oxygen requirements or death. RESULTS: A total of 116 HRV/ENT, 102 RSV, 99 FLU, and 64 other common respiratory viruses were identified. Children with single HRV/ENT infections presented with significantly higher rates of underlying immunosuppressive conditions compared to those with RSV (37·9% versus 13·6%; P < 0·001), FLU (37·9% versus 22%; P = 0·018) or any other single viral infection (37·9% versus 22·5%; P = 0·024). In multivariable analysis adjusted for underlying conditions and age, children with HRV/ENT infections had increased odds of hospitalization compared to children with RSV infections (OR 2·6; 95% CI 1·4, 4·8; P < 0·003) or FLU infections (OR 3·0; 95% CI 1·6, 5·8; <0·001) and increased odds of severe clinical disease among inpatients (OR 3·0; 95% CI 1·6,5·6; P = 0·001) when compared to those with FLU infections. CONCLUSIONS: Children with HRV/ENT had a more severe clinical course than those with RSV and FLUA/B infections and often had significant comorbidities. These findings emphasize the importance of considering HRV/ENT infection in children presenting with severe acute respiratory tract infections. url: https://doi.org/10.1111/irv.12255 doi: 10.1111/irv.12255 id: cord-009877-3cyz6o9c author: Barclay, Wendy S. title: Evaluation of an enzyme‐linked immunosorbent assay that measures rhinovirus‐specific antibodies in human sera and nasal secretions date: 2005-12-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Rhinovirus‐specific antibodies have traditionally been detected by their ability to neutralise the homologous rhinovirus serotype in tissue culture. Recently, however, we have described an enzyme‐linked immunosorbent assay that detects rhinovirus‐specific antibodies in sera and nasal secretions [Barclay and Al‐Nakib, 1987]. Here we describe an evaluation of the ELISA in a study involving 71 adult volunteers inoculated intranasally with human rhinovirus type 2 (HRV‐2). Pre‐and post‐inoculation serum samples and pre‐inoculation nasal washings were tested for the presence of HRV‐2‐specific antibodies by ELISA. Such antibodies were associated with protection against infection when present locally in nasal secretions, but when also present in the serum they were associated with protection against both infection and the development of illness. The antibody concentrations showed strong correlation with each other and with that of antibodies detected by the neutralisation test. Following HRV‐2 infection, rises in HRV‐2‐specific IgA in sera detected by ELISA occurred more frequently than rises in neutralizing antibody. These results suggest that the ELISA is a sensitive and reliable indicator of recent infection, as well as a predictor of homologous immune status. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166658/ doi: 10.1002/jmv.1890250411 id: cord-354011-v9t2b2ca author: Benkouiten, Samir title: Circulation of Respiratory Viruses Among Pilgrims During the 2012 Hajj Pilgrimage date: 2013-10-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background. The Hajj is the oldest and largest annual mass gathering in the world and may increase the risk of spread of respiratory viruses. Methods. We performed a prospective survey among a cohort of pilgrims departing from Marseille, France, to Mecca in the Kingdom of Saudi Arabia (KSA) for the 2012 Hajj season. Nasal swabs were collected from participants and tested for 11 respiratory viruses by real-time reverse transcription polymerase chain reaction. Results. Of 165 participants sampled before departing to the KSA, 8 (4.8%) were positive for at least 1 virus (5 rhinovirus, 1 influenza C, 1 adenovirus, and 1 enterovirus). Seventy symptomatic pilgrims underwent additional nasal swabs during their pilgrimage in the KSA, of which 27 (38.6%) were positive for at least 1 virus (19 rhinovirus, 6 influenza A, 1 influenza C, 1 respiratory syncytial virus B, 1 metapneumovirus, 1 adenovirus, and 1 enterovirus). This was significantly higher than the 4.8% who were positive before departing for the KSA (P < .001). Of 154 pilgrims sampled before leaving the KSA, 17 (11%) were positive for at least 1 virus (13 rhinovirus, 3 adenovirus, 2 influenza B, and 1 enterovirus), which was also significantly higher than the percentage of positive pilgrims (4.8%), before departing for the KSA (P = .040). Conclusions. This study suggests a rapid acquisition of respiratory viruses among pilgrims during their stay in the KSA, most notably rhinovirus, and highlights the potential of spreading these infections in the pilgrims' home countries upon their return. url: https://www.ncbi.nlm.nih.gov/pubmed/23839997/ doi: 10.1093/cid/cit446 id: cord-259997-8f8di4eu author: Botti, Chiara title: Characterization of respiratory infection viruses in hospitalized children from Naples province in Southern Italy date: 2018-04-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Most acute respiratory infections (ARIs) in children are due to viral etiology, and represent an important cause of mortality and morbidity in children <5 years old in developing countries. The pathogens that cause ARIs vary geographically and by season, and viruses serve a major role. In the present study, the distribution of the seven respiratory viruses that are more prevalent in Southern European countries were retrospectively analyzed in a Southern Italy Hospital, that centralizes pediatric diseases from the Naples province. Viruses were categorized by a FilmArray Respiratory Panel, and demonstrated no substantial differences in sex, age and seasonal viruses distribution. However, all the investigated viruses had a higher detection rate in the surrounding municipalities than in the metropolitan area of Naples. In recent years, the association between air pollution and respiratory infections has become an increasing public health concern. The data in this study support this association in the surrounding areas of Naples extensively contaminated by environmental toxic agents. In these areas, characterization of the epidemiology of ARIs is required to implement a prevention and control program. url: https://www.ncbi.nlm.nih.gov/pubmed/29805499/ doi: 10.3892/etm.2018.6061 id: cord-284875-hsa2r7ns author: Bourdillon, N. title: Effects of COVID-19 lockdown on heart rate variability date: 2020-08-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Introduction: Strict lockdown rules were imposed to the French population from 17 March to 11 May 2020, which may result in limited possibilities of physical activity, modified psychological and health states. This report is focused on HRV parameters kinetics before, during and after this lockdown period. Methods: 95 participants were included in this study, who underwent regular orthostatic tests (a 5-minute supine followed by a 5-minute standing recording of heart rate (HR)) on a regular basis before, during and after the lockdown (BSL, CFN and RCV, respectively). HR, power in low- and high-frequency bands (LF, HF, respectively) and root mean square of the successive differences (RMSSD) were computed for each orthostatic test, and for each positions. Subjective well-being was assessed on a 0-10 visual analogic scale (VAS). Results: Out of the 95 participants, 19 (WB+) reported an improved well-being (i.e., increase >2 in VAS score) during CFN, contradictory to the 76 other participants (WB-). There was an increase in HR and a decrease in RMSSD when measured supine in CFN and RCV, compared to BSL in WB-, whilst opposite results were found in WB+ (i.e. decrease in HR and increase in RMSSD in CFN and RCV; increase in LF and HF in RCV). There was a moderate significant correlation between VAS and HR, RMSSD, HF, respectively, in the supine position; the higher the VAS score (i.e., subjective well-being), the higher the RMSSD and HF and the lower the HR. In standing position, HRV parameters were not modified during CFN. Conclusion: The strict COVID-19 lockdown likely had opposite effects on French population as 20% of participants improved parasympathetic activation (RMSSD, HF) and rated positively this period, whilst 80% showed altered responses and deteriorated well-being. The changes in HRV parameters during and after the lockdown period were in line with subjective well-being responses. These results confirmed the usefulness of HRV as a non-invasive means for monitoring well-being and health in the general population. url: https://doi.org/10.1101/2020.07.30.20165118 doi: 10.1101/2020.07.30.20165118 id: cord-287063-kheek4lx author: Carroll, Kecia N. title: Influence of maternal asthma on the cause and severity of infant acute respiratory tract infections date: 2012-02-14 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Respiratory syncytial virus (RSV) and rhinovirus infections are the most common significant infant respiratory tract illnesses and are associated with increased but differential risks of childhood asthma. OBJECTIVE: We sought to determine whether maternal asthma is associated with higher odds of infant respiratory tract infection with rhinovirus versus RSV and increased infection severity. METHODS: Mother-infant dyads were enrolled from 2004-2008 during an infant respiratory tract infection (104 with rhinovirus and 279 with RSV). Mothers were classified into mutually exclusive groups (atopic asthma, nonatopic asthma, and no asthma). We determined viral cause using PCR and the severity of the infant’s respiratory tract infection using the bronchiolitis severity score. Adjusted relative odds of maternal asthma with viral cause were calculated by using logistic regression. Proportional odds models assessed the association of maternal asthma and infant infection severity. RESULTS: Infants with a mother with atopic asthma compared with infants whose mothers did not have asthma were more likely to have rhinovirus versus RSV infection (adjusted odds ratio, 2.42; 95% CI, 1.19-4.90). Similarly, among infants with rhinovirus, having a mother with atopic asthma was associated with increased infection severity (adjusted odds ratio, 3.10; 95% CI, 1.21-7.98). This relationship was not seen among infants with RSV. CONCLUSIONS: Clinically significant rhinovirus infection during infancy was more strongly associated with having a mother with atopic asthma than clinically significant RSV infection. Having a mother with atopic asthma was associated with increased severity of infant rhinovirus but not RSV infections. Infants with rhinovirus were more likely to have a familial atopic predisposition, which might partly explain the subsequent increased asthma risk. url: https://www.sciencedirect.com/science/article/pii/S009167491200139X doi: 10.1016/j.jaci.2012.01.045 id: cord-010160-wk8k2igu author: Chandrasekaran, Alamelu title: Broad reactivity of the Luminex xTAG Respiratory Virus Panel (RVP) assay for the detection of human rhinoviruses date: 2012-01-04 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172171/ doi: 10.1016/j.jcv.2011.12.006 id: cord-316245-n6tmn4ph author: Cui, Binglin title: Viral aetiology of acute respiratory infections among children and associated meteorological factors in southern China date: 2015-03-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Acute respiratory infections (ARIs) are common in children and mostly caused by viruses, but the significance of the detection of multiple viruses in ARIs is unclear. This study investigated 14 respiratory viruses in ARIs among children and associated meteorological factors in Shantou, southern China. METHODS: Paired nasal/throat-flocked swabs collected from 1,074 children with ARIs, who visited outpatient walk-in clinics in a tertiary hospital between December 2010 and November 2011, were examined for fourteen respiratory viruses - influenza viruses (FluA, FluB), respiratory syncytial viruses (RSV A and B), human coronaviruses (hCoV: 229E, OC43, HKU1, NL63), human metapneumoviruses (hMPV A and B), parainfluenza viruses (PIV1-4), human rhinoviruses (HRV A, B, C), enteroviruses (EV), adenoviruses (ADV), human bocavirus (hBoV), and human parechoviruses (hPeV) - by multiplex real-time PCR. RESULTS: We identified at least one virus in 82.3% (884/1,074) and multiple viruses in 38.6% (415/1,074) of patients. EV and HRV were the most frequently detected single viruses (42.3%, 374/884 and 39.9%, 353/884 respectively) and co-detected pair (23.1%, 96/415). Overlapping seasonal trends of viruses were recorded over the year, with dual peaks for EV and single peaks for the others. By logistic regression analysis, EV was positively associated with the average temperature and humidity, hCoV, and PIV4, but negatively with HRV, PIV3, and hBoV. HRV was inversely associated with EV and PIV3. CONCLUSIONS: This study reports high viral detection and co-detection rates in pediatric ARI cases mainly due to EV and HRV. Many viruses circulated throughout the year with similar seasonal trends in association with temperature, humidity, and wind velocity. Statistically significant associations were present among the viruses. Understanding the polyviral etiology and viral interactions in the cases with multiple viruses warrants further studies. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s12879-015-0863-6) contains supplementary material, which is available to authorized users. url: https://www.ncbi.nlm.nih.gov/pubmed/25884513/ doi: 10.1186/s12879-015-0863-6 id: cord-316319-m6uha1qn author: Daleno, Cristina title: Phylogenetic Analysis of Human Rhinovirus Isolates Collected from Otherwise Healthy Children with Community-Acquired Pneumonia during Five Successive Years date: 2013-11-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: In order to evaluate the circulation of the different human rhinovirus (HRV) species and genotypes in Italian children with radiographically confirmed community-acquired pneumonia (CAP), a nasopharyngeal swab was obtained from 643 children admitted to hospital because of CAP during five consecutive winter and early spring seasons (2007-2012). Real-time reverse transcriptase polymerase chain reaction (RT-PCR) was used to identify HRV, and the HRV-positive samples were used for sequencing analysis and to reconstruct the phylogenetic tree. HRV was identified in 198 samples (42.2%), and the VP4/VP2 region was successfully amplified in 151 (76.3%). HRV-A was identified in 78 samples (51.6%), HRV-B in 14 (9.3%) and HRV-C in 59 (39.1%). Forty-seven (31.1%) of the children with HRV infection were aged <1 year, 71 (47.0%) were aged 1-3 years, and 33 (21.9%) were aged ≥4 years. Blast and phylogenetic analyses showed that the HRV strains were closely related to a total of 66 reference genotypes, corresponding to 29 HRV-A, 9 HRV-B and 28 HRV-C strains. Nucleotide variability was 37% between HRV-A and HRV-B, 37.3% between HRV-A and HRV-C, and 39.9% between HRV-B and HRV-C. A number of sequences clustered with known serotypes and, within these clusters, there were strains circulating during several seasons. The most frequently detected genotypes were HRV-A78 (n=17), HRV-A12 (n=9) and HRV-C2 (n=5). This study shows that, although it is mainly associated with HRV-A, pediatric CAP can also be diagnosed in subjects infected by HRV-C and, more rarely, by HRV-B. Moreover, a large number of genotypes may be involved in causing pediatric CAP and can be different from year to year. Although the prolonged circulation of the same genotypes can sometimes be associated with a number of CAP episodes in different years. url: https://doi.org/10.1371/journal.pone.0080614 doi: 10.1371/journal.pone.0080614 id: cord-009922-t1hoox6e author: Dearden, C. J. title: Direct detection of rhinoviruses by an enzyme‐linked immunosorbent assay date: 2005-12-07 words: 4065.0 sentences: 205.0 pages: flesch: 55.0 cache: ./cache/cord-009922-t1hoox6e.txt txt: ./txt/cord-009922-t1hoox6e.txt summary: This paper describes the first enzyme‐linked immunosorbent assay for the detection of rhinovirus antigens in clinical specimens (nasal washings), either directly or following overnight cell culture amplification. Secondly, a direct ELISA system was developed in which the nasal washings or control antigen (uninfected tissue culture fluid) were added directly to each of a set of duplicate ELISA plate wells coated with either pre-or postchallenge rabbit anti HRV-EL hyperimmune serum. Figure 2 shows the results obtained with nasal washings, collected from three volunteers on consecutive days following HKV-EL or saline challenge, tested in both the cell-culture-amplified (CCA)-ELISA and direct ELISA systems. Although we would like to emphasise that our data are preliminary, both the direct and CCA-ELISAs gave a good correlation with virus isolation when used to detect rhinovirus antigens in nasal washings (obtained from 18 volunteers challenged with either HRV-EL or saline). abstract: This paper describes the first enzyme‐linked immunosorbent assay for the detection of rhinovirus antigens in clinical specimens (nasal washings), either directly or following overnight cell culture amplification. The assay takes approximately 48 hours to perform and utilizes the same rabbit antirhinovirus hyperimmune serum as both the capture and detecting antibody. The latter has been biotin‐labelled and is detected via a streptavidin 3‐galactosidase preformed complex. This new assay has been found to be very sensitive, detecting human rhinovirus (HRV)‐EL and HRV‐2 at titres as low as 10(1.8) TCID(50) 100 μl(−1) and < 10(1) TCID(50) 100 μl(−1), respectively. Furthermore, when 57 different human rhinovirus serotypes were tested in both the HRV‐EL and HRV‐2 ELISA systems a total of 49 (86%) were found to be cross‐reactive. Of 36 clinical specimens tested by virus isolation, cell‐culture‐amplified (CCA) ELISA, and direct ELISA, 15 were positive by isolation, 11 by CCA‐ELISA, and 11 by direct ELISA. The overall correlation of the CCA and direct ELISA techniques with virus isolation was found to be 88.9% and 66.7%, respectively. The present study demonstrates that the ELISA system developed is a sensitive technique for the diagnosis of rhinovirus infections. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7166933/ doi: 10.1002/jmv.1890230211 id: cord-023713-daz2vokz author: Devereux, Graham title: Epidemiology of Asthma and Allergic Airway Diseases date: 2013-09-06 words: 27880.0 sentences: 1480.0 pages: flesch: 51.0 cache: ./cache/cord-023713-daz2vokz.txt txt: ./txt/cord-023713-daz2vokz.txt summary: A systematic review and metaanalysis of the longitudinal studies relating maternal vitamin D status during pregnancy to childhood outcomes concluded that high maternal dietary vitamin D intake is associated with a reduced risk of children wheezing up to the age of 5 years (OR = 0.56; 95% CI, 0.42 to 0.73). The Dutch Prevention and Incidence of Asthma and Mite allergy (PIAMA) birth cohort study related symptom data prospectively collected annually from 3863 children up to the age of 8 years to land-use regression estimates of individual NO 2 , PM 2.5 , and soot exposures at their birth addresses. 327 A systematic review and meta-analysis of prospective birth cohort studies evaluating the effects of allergen (i.e., HDM or dietary) avoidance during pregnancy concluded that early-life allergen avoidance in isolation does not reduce the likelihood of asthma in children at age 5 years (OR = 1.22; 95% CI, 0.83 to 1.78). abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173512/ doi: 10.1016/b978-0-323-08593-9.00049-8 id: cord-268093-ta6k0uyz author: Etemadi, Mohammad Reza title: Biodiversity and clinico-demographic characteristics of human rhinoviruses from hospitalized children with acute lower respiratory tract infections in Malaysia() date: 2013-08-07 words: 3354.0 sentences: 173.0 pages: flesch: 50.0 cache: ./cache/cord-268093-ta6k0uyz.txt txt: ./txt/cord-268093-ta6k0uyz.txt summary: The presence of the new HRV-C strain in severe respiratory disease has further instilled research interest in the clinical impact, molecular biology and epidemiology of HRVs. As research of HRV is limited [8] , especially in Asian developing countries, this study aims to examine the molecular epidemiology, the demographic characteristics and clinical features including the newly discovered HRV-C species, among hospitalized children less than 5 years of age with ALRTI in Malaysia. HRV infected patients were admitted earlier compared to RSV and influenza; children with HRV presented to the hospital after a mean duration of 1.9 days (ranged 1-9 days) as compared with HRV (4.0 days, p = <0.001) and IFV-A (4.8 days, p = 0.002). Our study revealed that HRV infected children were hospitalized earlier in the course of their disease and were less febrile on presentation as compared to RSV and IFV-A infections. abstract: BACKGROUND: There is accumulating evidence that human rhinovirus (HRV) causes acute lower respiratory tract infections (ALRTI). Recently, HRV-C was identified as a new species of HRV, but its spectrum of clinical disease is not well understood. OBJECTIVES: We investigated the molecular epidemiology, demographic and clinical characteristics of HRVs among hospitalized children with ALRIs. STUDY DESIGN: One hundred and sixty-five nasopharangeal aspirates taken from children <5 years hospitalized with ALRTIs in Serdang Hospital, Malaysia, were subject to reverse transcriptase-PCR for HRV. Phylogenetic analysis on VP4/VP2 and 5′-NCR regions was used to further characterize HRV. Other respiratory viruses were also investigated using semi-nested multiplex RT-PCR assay. Clinical parameters were analyzed between HRV, RSV and IFV-A mono-infections and between HRV species. RESULTS: HRV was detected in 54 (33%) patients for both single (36 samples) and multiple (18 samples) infections, 61.1% (22/36) represents HRV-A strains while the remaining 14 HRV-C. Strain P51was the first reported representative of HRV98. The majority of the single HRV cases were in the second half of infancy; HRV-C occurred among older children compared with HRV-A. HRV children were admitted significantly earlier and less febrile than RSV and IFV-A infection. HRV-C infected children were more likely to have rhonchi and vomiting as compared to HRV-A. Pneumonia was the most common discharge diagnosis followed by bronchiolitis and post-viral wheeze in HRV patients. CONCLUSION: Our study showed high prevalence of HRVs and detection of HRV-C among hospitalized children with ALRTIs in Malaysia. Analysis of clinical parameters suggested specific features associated with HRVs infections and specific HRV groups. url: https://api.elsevier.com/content/article/pii/S1386653213001972 doi: 10.1016/j.jcv.2013.05.017 id: cord-281162-2pu7x5rj author: Etemadi, Mohammad Reza title: Diversity of respiratory viruses detected among hospitalized children with acute lower respiratory tract infections at Hospital Serdang, Malaysia date: 2019-03-22 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: The role of respiratory viruses as the major cause of acute lower respiratory tract infections (ALRTIs) in children is becoming increasingly evident due to the use of sensitive molecular detection methods. The aim of this study was to use conventional and molecular detection methods to assess the epidemiology of respiratory viral infections in children less than five years of age that were hospitalized with ALRTIs. METHODS: The cross-sectional study was designed to investigate the occurrence of respiratory viruses including respiratory syncytisl virus (RSV), human metapneumovirus (HMPV), influenza virus A and B (IFV-A and B), parainfluenzavirus 1, 2, 3 and 4 (PIV 1, 2, 3 and 4), human rhinoviruses (HRV), human enterovirus (HEV), human coronaviruses (HCoV) 229E and OC43, human bocavirus (HBoV) and human adenovirus (HAdV) in hospitalized children with ALRTIs, at Hospital Serdang, Malaysia, from June 16 to December 21, 2009. The study was also designed in part to assess the performance of the conventional methods against molecular methods. RESULTS: Viral pathogens were detected in 158 (95.8%) of the patients. Single virus infections were detected in 114 (67.9%) patients; 46 (27.9%) were co-infected with different viruses including double-virus infections in 37 (22.4%) and triple-virus infections in 9 (5.5%) cases. Approximately 70% of samples were found to be positive using conventional methods compared with 96% using molecular methods. A wide range of respiratory viruses were detected in the study. There was a high prevalence of RSV (50.3%) infections, particularly group B viruses. Other etiological agents including HAdV, HMPV, IFV-A, PIV 1–3, HBoV, HCoV-OC43 and HEV were detected in 14.5, 9.6, 9.1, 4.8, 3.6, 2.4 and 1.8 percent of the samples, respectively. CONCLUSION: Our results demonstrated the increased sensitivity of molecular detection methods compared with conventional methods for the diagnosis of ARTIs in hospitalized children. This is the first report of HMPV infections in Malaysia. url: https://www.sciencedirect.com/science/article/pii/S0166093418305937 doi: 10.1016/j.jviromet.2019.03.013 id: cord-328795-rs1sd42z author: Falsey, Ann R. title: Rhinoviruses date: 2016-10-24 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Human rhinoviruses (HRV) are ubiquitous pathogens and the leading cause of the common cold syndrome. HRV are very diverse with more than 100 serotypes identified which cause disease in persons of all ages with the highest incidence documented in young children. Although illness is typically mild and self-limited, lost time from work and school creates a considerable economic burden. Infection of the upper airways is the most common site of infection, although lower airways disease is also well documented, as is the link between HRV infection and exacerbations of asthma. Unfortunately, effective specific antiviral treatments and vaccines remain elusive. url: https://www.sciencedirect.com/science/article/pii/B9780128036785003866 doi: 10.1016/b978-0-12-803678-5.00386-6 id: cord-314841-b5l6epy3 author: Falsey, Ann Regina title: Respiratory viral infections date: 2019-08-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Molecular analysis of respiratory viruses and the host response to both infection and vaccination have transformed our understanding of these ubiquitous pathogens. Polymerase chain reaction for the rapid and accurate diagnosis of viral infections has led to a better understanding of the epidemiology and impact of many common respiratory viruses and resulted in better patient care. Over the past decade a number of new respiratory viruses including human metapneumovirus and new coronaviruses have been discovered using molecular techniques such as random primer amplification, pan-viral array and next generation sequencing. Analysis of the host transcriptional response during respiratory viral infection using in-vitro, animal models and natural and experimental human challenge have furthered the understanding of the mechanisms and predictors of severe disease and may identify potential therapeutic targets to prevent and ameliorate illness. url: https://www.sciencedirect.com/science/article/pii/B9780128014967000095 doi: 10.1016/b978-0-12-801496-7.00009-5 id: cord-000483-zgapjjjw author: Faux, Cassandra E. title: Usefulness of Published PCR Primers in Detecting Human Rhinovirus Infection date: 2011-02-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: We conducted a preliminary comparison of the relative sensitivity of a cross-section of published human rhinovirus (HRV)–specific PCR primer pairs, varying the oligonucleotides and annealing temperature. None of the pairs could detect all HRVs in 2 panels of genotyped clinical specimens; >1 PCR is required for accurate description of HRV epidemiology. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204776/ doi: 10.3201/eid1702.101123 id: cord-225218-x32a4sp3 author: Filntisis, Panagiotis P. title: Identifying differences in physical activity and autonomic function patterns between psychotic patients and controls over a long period of continuous monitoring using wearable sensors date: 2020-10-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Digital phenotyping is a nascent multidisciplinary field that has the potential to revolutionize psychiatry and its clinical practice. In this paper, we present a rigorous statistical analysis of short-time features extracted from wearable data, during long-term continuous monitoring of patients with psychotic disorders and healthy control counterparts. Our novel analysis identifies features that fluctuate significantly between the two groups, and offers insights on several factors that differentiate them, which could be leveraged in the future for relapse prevention and individualized assistance. url: https://arxiv.org/pdf/2011.02285v1.pdf doi: nan id: cord-004749-wyzb8v4a author: Forsyth, M. title: Rhinovirus detection using probes from the 5′ and 3′ end of the genome date: 1989 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This study investigated the abilities of cDNA probes from the 5′ and 3′ ends of the genome of human rhinoviruses (HRV-) 14, 9, and 1B to detect RNA from 59 rhinovirus serotypes. The results show that probes from the 5′ end of the genomes of HRV-14, 9, and 1B detected a large number of serotypes but the detection rate was variable and depended on the degree of homology with the particular probe. In contrast, all the 3′ end probes were specific for the homologous virus. However, along HRV-9 probe detected a large number of serotypes. It was concluded that such cDNA probes would not detect all serotypes with equal efficiency. Synthetic oligonucleotides corresponding to short but highly conserved regions in the 5′ non coding region may overcome this problem. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086855/ doi: 10.1007/bf01313878 id: cord-327610-cm3vkpcn author: Fukuda, Yosuke title: Virus-Induced Asthma Exacerbations: SIRT1 Targeted Approach date: 2020-08-13 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: The prevalence of asthma has increased worldwide. Asthma exacerbations triggered by upper respiratory tract viral infections remain a major clinical problem and account for hospital admissions and time lost from work. Virus-induced asthma exacerbations cause airway inflammation, resulting in worsening asthma and deterioration in the patients’ quality of life, which may require systemic corticosteroid therapy. Despite recent advances in understanding the cellular and molecular mechanisms underlying asthma exacerbations, current therapeutic modalities are inadequate for complete prevention and treatment of these episodes. The pathological role of cellular senescence, especially that involving the silent information regulator 2 homolog sirtuin (SIRT) protein family, has recently been demonstrated in stable and exacerbated chronic respiratory disease states. This review discusses the role of SIRT1 in the pathogenesis of bronchial asthma. It also discusses the role of SIRT1 in inflammatory cells that play an important role in virus-induced asthma exacerbations. Recent studies have hypothesized that SIRT1 is one of major contributors to cellular senescence. SIRT1 levels decrease in Th2 and non-Th2-related airway inflammation, indicating the role of SIRT1 in several endotypes and phenotypes of asthma. Moreover, several models have demonstrated relationships between viral infection and SIRT1. Therefore, targeting SIRT1 is a novel strategy that may be effective for treating virus-induced asthma exacerbations in the future. url: https://doi.org/10.3390/jcm9082623 doi: 10.3390/jcm9082623 id: cord-327344-8gi1wb76 author: Gambarino, Stefano title: Development of a RT Real-Time PCR for the Detection and Quantification of Human Rhinoviruses date: 2009-03-17 words: 3506.0 sentences: 147.0 pages: flesch: 38.0 cache: ./cache/cord-327344-8gi1wb76.txt txt: ./txt/cord-327344-8gi1wb76.txt summary: This article describes the development and optimization of a reverse transcription (RT) real-time PCR assay for quantification of HRV RNA in clinical samples. Clinical specimens originated from the Virology Unit of the Fig. 1 Standard curve (from 10 2 to 10 5 copies/reaction) and dynamic range (from 10 7 to 10 1 copies/reaction) of the real-time RT-PCR developed in this study Azienda Ospedaliero-Universitaria San Giovanni Battista, Turin, and included 110 bronchoalveolar lavages (BAL) obtained from 84 patients (M/F, 57/27; mean age, 57.8 years; range, . The performance of the RT real-time PCR developed in this study was examined over different concentrations of HRV RNA and it was found to be very sensitive with a minimum cut-off for detection of 10 0 copy/reaction and was linear up to 10 1 copies. In conclusion, the RT real-time PCR assay developed in this study could represent a useful tool for diagnosing HRV infections, quantifying the viral load and could be applicable for routine diagnostic workup of upper as well as lower respiratory tract diseases. abstract: Human Rhinoviruses (HRV) are the most common viral agents, being responsible for upper as well as lower respiratory tract infections. Evidence demonstrating that HRV disease is not exclusively limited to the upper airways and may cause lower respiratory complications, together with the frequency of HRV infections and the increasing number of immunocompromised patients underline the need for including HRV in virological diagnostics of acute lower respiratory tract illness. This article describes the development and optimization of a reverse transcription (RT) real-time PCR assay for quantification of HRV RNA in clinical samples. Efficiency, sensitivity, specificity, inter- and intra-assay variability, and dynamic range have been determined. Subsequently, the assay has been validated on bronchoalveolar lavage (BAL) specimens obtained from immunocompetent and immunocompromised patients. url: https://doi.org/10.1007/s12033-009-9164-x doi: 10.1007/s12033-009-9164-x id: cord-317198-mean7sj9 author: Giamberardin, Heloisa I.G. title: Clinical and epidemiological features of respiratory virus infections in preschool children over two consecutive influenza seasons in southern Brazil date: 2016-02-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: This study reports the results of a systematic screening for respiratory viruses in pediatric outpatients from an emergency department (ED) in southern Brazil during two consecutive influenza seasons. Children eligible for enrollment in this study were aged 24–59 months and presented with acute respiratory symptoms and fever. Naso‐ and oropharyngeal swabs were collected and multiplex reverse transcription PCR (RT‐PCR) was performed to identify the respiratory viruses involved. In total, 492 children were included in this study: 248 in 2010 and 244 in 2011. In 2010, 136 samples (55%) were found to be positive for at least one virus and the most frequently detected viruses were human rhinovirus (HRV) (18%), adenovirus (AdV) (13%), and human coronavirus (CoV) (5%). In 2011, 158 samples (65%) were found to be positive for at least one virus, and the most frequently detected were HRV (29%), AdV (12%), and enterovirus (9%). Further, the presence of asthma (OR, 3.17; 95% CI, 1.86–5.46) was independently associated with HRV infection, whereas fever was associated with AdV (OR, 3.86; 95% CI, 1.31–16.52) and influenza infections (OR, 3.74; 95% CI, 1.26–16.06). Ten patients (2%) were diagnosed with pneumonia, and six of these tested positive for viral infection (4 HRV, 1 RSV, and 1 AdV). Thus, this study identified the most common respiratory viruses found in preschool children in the study region and demonstrated their high frequency, highlighting the need for improved data collection, and case management in order to stimulate preventive measures against these infections. J. Med. Virol. 88:1325–1333, 2016. © 2016 Wiley Periodicals, Inc. url: https://www.ncbi.nlm.nih.gov/pubmed/26773605/ doi: 10.1002/jmv.24477 id: cord-310171-1fmsxx2s author: Goffard, Anne title: Virus and cystic fibrosis: Rhinoviruses are associated with exacerbations in adult patients() date: 2014-02-25 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Few studies have suggested the potential role of respiratory viruses in cystic fibrosis (CF) exacerbation, but their real impact is probably underestimated. METHOD: Sixty-four sputum samples collected from 46 adult patients were included in the study: 33 samples were collected during exacerbation of CF, and 31 during the stable phase. After extraction, nucleic acids were tested for the presence of respiratory viruses. When rhinovirus (HRV) was detected, the 5′UTR and VP4/2 regions were sequenced, and phylogenetically analyzed. The characteristics of patients in exacerbation and stable phase were compared. RESULTS: Viruses were found in 25% of samples. The HRV viruses were the most frequently detected followed by coronaviruses. Only the HRV detection was significantly associated with the occurrence of CF pulmonary exacerbation (p < 0.027). Characterization of 5′UTR and VP4/2 regions of the HRV genome specified that HRV-A, -B, -C were detected. All HRV-C were recombinant HRV-Ca. CONCLUSIONS: HRV were the most frequently detected viruses; their detection was significantly associated with the occurrence of an exacerbation. The reality of viral recombination between HRV was demonstrated in CF patients for the first time, raising the role of viruses in lung microbiota. Further studies are now warranted to decipher virus impact in CF. url: https://doi.org/10.1016/j.jcv.2014.02.005 doi: 10.1016/j.jcv.2014.02.005 id: cord-307990-skrye40w author: Hai, Le Thanh title: Fatal Respiratory Infections Associated with Rhinovirus Outbreak, Vietnam date: 2012-11-17 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: During an outbreak of severe acute respiratory infections in 2 orphanages, Vietnam, 7/12 hospitalized children died. All hospitalized children and 26/43 children from outbreak orphanages tested positive for rhinovirus versus 9/40 control children (p = 0.0005). Outbreak rhinoviruses formed a distinct genetic cluster. Human rhinovirus is an underappreciated cause of severe pneumonia in vulnerable groups. url: https://www.ncbi.nlm.nih.gov/pubmed/23092635/ doi: 10.3201/eid1811.120607 id: cord-004694-43yvs52a author: Han, Tae-Hee title: Detection of human rhinovirus C in children with acute lower respiratory tract infections in South Korea date: 2009-05-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Recently, HRV-C was identified as a new species of HRV, but its spectrum of clinical disease is still not clear. The purpose of this study was to investigate the molecular epidemiology of HRVs in children with acute lower respiratory tract infections (LRTIs). A total of 54 HRV-positive samples that were negative for other respiratory viruses were sequenced. HRV-A was detected in 33, HRV-B in 4, and HRV-C in 17 of these samples. All HRV-C-positive patients showed favorable clinical outcomes. We confirmed the presence of HRV-C in children with LRTIs, but its association with clinical severity is not clear. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086646/ doi: 10.1007/s00705-009-0383-z id: cord-000082-jy7j8sh0 author: Huang, Ting title: Evidence of Recombination and Genetic Diversity in Human Rhinoviruses in Children with Acute Respiratory Infection date: 2009-07-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Human rhinoviruses (HRVs) are a highly prevalent cause of acute respiratory infection in children. They are classified into at least three species, HRV-A, HRV-B and HRV-C, which are characterized by sequencing the 5′ untranslated region (UTR) or the VP4/VP2 region of the genome. Given the increased interest for novel HRV strain identification and their worldwide distribution, we have carried out clinical and molecular diagnosis of HRV strains in a 2-year study of children with acute respiratory infection visiting one district hospital in Shanghai. METHODOLOGY/FINDINGS: We cloned and sequenced a 924-nt fragment that covered part of the 5′UTR and the VP4/VP2 capsid genes. Sixty-four HRV-infected outpatients were diagnosed amongst 827 children with acute low respiratory tract infection. Two samples were co-infected with HRV-A and HRV-B or HRV-C. By comparative analysis of the VP4/VP2 sequences of the 66 HRVs, we showed a high diversity of strains in HRV-A and HRV-B species, and a prevalence of 51.5% of strains that belonged to the recently identified HRV-C species. When analyzing a fragment of the 5′ UTR, we characterized at least two subspecies of HRV-C: HRV-Cc, which clustered differently from HRV-A and HRV-B, and HRV-Ca, which resulted from previous recombination in this region with sequences related to HRV-A. The full-length sequence of one strain of each HRV-Ca and HRV-Cc subspecies was obtained for comparative analysis. We confirmed the close relationship of their structural proteins but showed apparent additional recombination events in the 2A gene and 3′UTR of the HRV-Ca strain. Double or triple infections with HRV-C and respiratory syncytial virus and/or bocavirus were diagnosed in 33.3% of the HRV-infected patients, but no correlation with severity of clinical outcome was observed. CONCLUSION: Our study showed a high diversity of HRV strains that cause bronchitis and pneumonia in children. A predominance of HRV-C over HRV-A and HRV-B was observed, and two subspecies of HRV-C were identified, the diversity of which seemed to be related to recombination with former HRV-A strains. None of the HRV-C strains appeared to have a higher clinical impact than HRV-A or HRV-B on respiratory compromise. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2712091/ doi: 10.1371/journal.pone.0006355 id: cord-316932-fia1w9jt author: Ireland, D. C. title: Improved detection of rhinoviruses in nasal and throat swabs by seminested RT‐PCR date: 2005-12-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: A seminested RT‐PCR (nRT‐PCR) was used to detect picornavirus (PV) RNA in cell cultures inoculated with rhinoviruses (HRVs) and enteroviruses (EVs). PCR tests in which a primary "touchdown" PCR was followed by secondary reactions using PV or HRV specific primers were able to differentiate HRVs of 48 serotypes from EVs. PVnRT‐PCR and HRVnRT‐PCR were then used to test nasal and throat swabs from adult subjects with naturally acquired respiratory virus infections. The swabs were also analysed for respiratory viruses by cell culture techniques and the rates of PV identification by the two methods were compared. PVnRT‐PCR was found to be at least five times more sensitive than cell culture for the detection of PVs in these clinical specimens. Paired acute and convalescent serum samples were tested for complement fixing antibodies to adenovirus, influenza A and B, respiratory syncytial virus, parainfluenza viruses 1, 2, and 3, Myco plasma pneumoniae, and Chlamydia psittaci. An enzyme‐linked immunosorbent assay (ELISA) was used to detect rises in antibody level to coronavirus types 229E and OC43. The overall rate of pathogen identification in 159 swabs from adult asthmatics increased from 28% when only cell culture and serology were used to 57% when these methods were supplemented by PVnRT‐PCR. © 1993 Wiley‐Liss, Inc. url: https://www.ncbi.nlm.nih.gov/pubmed/8395557/ doi: 10.1002/jmv.1890400204 id: cord-272125-dez1nzg4 author: Jartti, T. title: Allergic sensitization is associated with rhinovirus‐, but not other virus‐, induced wheezing in children date: 2010-10-26 words: 3679.0 sentences: 208.0 pages: flesch: 48.0 cache: ./cache/cord-272125-dez1nzg4.txt txt: ./txt/cord-272125-dez1nzg4.txt summary: A specific immunoglobulin E (IgE) sensitization for common food and aeroallergens and other atopy‐related variables including total IgE, blood and nasal eosinophils, exhaled nitric oxide, eczema and atopic eczema, parental allergy and asthma, number of wheezing episodes, positive asthma predictive index or asthma and use of inhaled corticosteroid were correlated with specific viral etiology. The number of sensitizations was particularly associated with sole rhinovirus etiology (odds ratio 4.59; 95% confidence interval 1.78, 11.8; adjusted to age and sex), followed by aeroallergen sensitization (respectively; 4.18; 2.00, 8.72), total IgE level (2.06; 1.32, 3.21), food allergen sensitization (2.02; 1.08, 3.78), and nasal eosinophil count (1.52; 1.08, 2.13). Log 10 Number of sensitizations were particularly associated with sole HRV etiology (odds ratio 4.59; adjusted to age and sex), followed by aeroallergen sensitization (respectively, 4.18), total IgE level (2.06), food allergen sensitization (2.02), and nasal eosinophil count (1.52) (p < 0.05 for all, Fig. 1b , Table S2 ). abstract: Jartti T, Kuusipalo H, Vuorinen T, Söderlund‐Venermo M, Allander T, Waris M, Hartiala J, Ruuskanen O. Allergic sensitization is associated with rhinovirus‐, but not other virus‐, induced wheezing in children. Pediatr Allergy Immunol 2010: 21: 1008–1014. © 2010 John Wiley & Sons A/S Background: Data on the link between atopy and viral wheeze are limited. Aim: To evaluate the association between IgE sensitization and viral infection in wheezing children. Methods: This is an observational study in hospitalized wheezing children (n = 247; median age 1.6 ; interquartile range 1.1, 2.9). Eighteen respiratory viral infections were studied using all available methods. A specific immunoglobulin E (IgE) sensitization for common food and aeroallergens and other atopy‐related variables including total IgE, blood and nasal eosinophils, exhaled nitric oxide, eczema and atopic eczema, parental allergy and asthma, number of wheezing episodes, positive asthma predictive index or asthma and use of inhaled corticosteroid were correlated with specific viral etiology. Results: Atopy was closely associated with sole rhinovirus etiology (n = 58) but not with sole respiratory syncytial virus, sole enterovirus, sole human bocavirus, sole other virus, mixed viral, or virus negative etiology. The number of sensitizations was particularly associated with sole rhinovirus etiology (odds ratio 4.59; 95% confidence interval 1.78, 11.8; adjusted to age and sex), followed by aeroallergen sensitization (respectively; 4.18; 2.00, 8.72), total IgE level (2.06; 1.32, 3.21), food allergen sensitization (2.02; 1.08, 3.78), and nasal eosinophil count (1.52; 1.08, 2.13). Conclusions: According to our data, allergic sensitization is positively linked to rhinovirus‐, but not other virus‐, associated wheezing and calls attention for studies to test rhinovirus‐associated wheezing as a part of asthma risk indices. url: https://doi.org/10.1111/j.1399-3038.2010.01059.x doi: 10.1111/j.1399-3038.2010.01059.x id: cord-291486-5h96msv1 author: Kistler, Amy title: Pan-Viral Screening of Respiratory Tract Infections in Adults With and Without Asthma Reveals Unexpected Human Coronavirus and Human Rhinovirus Diversity date: 2007-09-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background. Between 50% and 80% of asthma exacerbations are associated with viral respiratory tract infections (RTIs), yet the influence of viral pathogen diversity on asthma outcomes is poorly understood because of the limited scope and throughput of conventional viral detection methods. Methods. We investigated the capability of the Virochip, a DNA microarray—based viral detection platform, to characterize viral diversity in RTIs in adults with and without asthma. Results. The Virochip detected viruses in a higher proportion of samples (65%) than did culture isolation (17%) while exhibiting high concordance (98%) with and comparable sensitivity (97%) and specificity (98%) to pathogen-specific polymerase chain reaction. A similar spectrum of viruses was identified in the RTIs of each patient subgroup; however, unexpected diversity among human coronaviruses (HCoVs) and human rhinoviruses (HRVs) was revealed. All but one of the HCoVs corresponded to the newly recognized HCoV-NL63 and HCoV-HKU1 viruses, and >20 different serotypes of HRVs were detected, including a set of 5 divergent isolates that formed a distinct genetic subgroup. Conclusions. The Virochip can detect both known and novel variants of viral pathogens present in RTIs. Given the diversity detected here, larger-scale studies will be necessary to determine whether particular substrains of viruses confer an elevated risk of asthma exacerbation. url: https://www.ncbi.nlm.nih.gov/pubmed/17703411/ doi: 10.1086/520816 id: cord-252347-vnn4135b author: Lee, Wai-Ming title: A Diverse Group of Previously Unrecognized Human Rhinoviruses Are Common Causes of Respiratory Illnesses in Infants date: 2007-10-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Human rhinoviruses (HRVs) are the most prevalent human pathogens, and consist of 101 serotypes that are classified into groups A and B according to sequence variations. HRV infections cause a wide spectrum of clinical outcomes ranging from asymptomatic infection to severe lower respiratory symptoms. Defining the role of specific strains in various HRV illnesses has been difficult because traditional serology, which requires viral culture and neutralization tests using 101 serotype-specific antisera, is insensitive and laborious. METHODS AND FINDINGS: To directly type HRVs in nasal secretions of infants with frequent respiratory illnesses, we developed a sensitive molecular typing assay based on phylogenetic comparisons of a 260-bp variable sequence in the 5' noncoding region with homologous sequences of the 101 known serotypes. Nasal samples from 26 infants were first tested with a multiplex PCR assay for respiratory viruses, and HRV was the most common virus found (108 of 181 samples). Typing was completed for 101 samples and 103 HRVs were identified. Surprisingly, 54 (52.4%) HRVs did not match any of the known serotypes and had 12–35% nucleotide divergence from the nearest reference HRVs. Of these novel viruses, 9 strains (17 HRVs) segregated from HRVA, HRVB and human enterovirus into a distinct genetic group (“C”). None of these new strains could be cultured in traditional cell lines. CONCLUSIONS: By molecular analysis, over 50% of HRV detected in sick infants were previously unrecognized strains, including 9 strains that may represent a new HRV group. These findings indicate that the number of HRV strains is considerably larger than the 101 serotypes identified with traditional diagnostic techniques, and provide evidence of a new HRV group. url: https://www.ncbi.nlm.nih.gov/pubmed/17912345/ doi: 10.1371/journal.pone.0000966 id: cord-258336-zs04l3s0 author: Leotte, Jaqueline title: Impact and seasonality of human rhinovirus infection in hospitalized patients for two consecutive years date: 2017-06-30 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Abstract Objectives To report epidemiological features, clinical characteristics, and outcomes of human rhinovirus (HRV) infections in comparison with other community acquired respiratory virus (CRV) infections in patients hospitalized for two consecutive years. Methods This was a cross-sectional study. Clinical, epidemiological, and laboratory data of patients hospitalized with acute respiratory syndrome in a tertiary care hospital from 2012 to 2013 were reviewed. Results HRV was the most common CRV observed (36%, 162/444) and was present in the majority of viral co-detections (69%, 88/128), mainly in association with human enterovirus (45%). Most HRV-infected patients were younger than 2 years (57%). Overall, patients infected with HRV had a lower frequency of severe acute respiratory infection than those infected with other CRVs (60% and 84%, respectively, p =0.006), but had more comorbidities (40% and 27%, respectively; p =0.043). However, in the adjusted analysis this association was not significant. The mortality rate within the HRV group was 3%. Detection of HRV was more prevalent during autumn and winter, with a moderately negative correlation between viral infection frequency and temperature (r =−0.636, p <0.001) but no correlation with rainfall (r =−0.036, p =0.866). Conclusion HRV is usually detected in hospitalized children with respiratory infections and is often present in viral co-detections. Comorbidities are closely associated with HRV infections. These infections show seasonal variation, with predominance during colder seasons. url: https://www.ncbi.nlm.nih.gov/pubmed/27916571/ doi: 10.1016/j.jped.2016.07.004 id: cord-299672-dq1y1gkc author: Leung, Ting Fan title: Multiplex Molecular Detection of Respiratory Pathogens in Children With Asthma Exacerbation date: 2010-02-28 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background Up to 80% of asthma exacerbations in white children are associated with viral upper respiratory infections. The relative importance of different respiratory pathogens and relevant microbiological data in Asian children are unclear. This study elucidated the epidemiology of respiratory infections in Hong Kong children with asthma exacerbation. Methods A total of 209 children aged 3-18 years with asthma exacerbations and 77 controls with stable asthma were recruited. The severity of asthma exacerbations was assessed according to Global Initiative for Asthma guideline, and subjects aged 6 years or older performed exhaled nitric oxide and spirometric measurements. Nested multiplex polymerase chain reaction was used to detect 20 different respiratory pathogens. Results Respiratory pathogens were detected in 105 (51.0%) subjects. The presence of any respiratory pathogen was associated with asthma exacerbation (odds ratio [OR], 2.77; 95% CI, 1.51–5.11; P < .001). Specifically, human rhinovirus (HRV) infection was more common among children with asthma exacerbation (OR, 2.38; 95% CI, 1.09–5.32; P = .018). All other pathogens or coinfections were not associated with asthmatic attacks. None of these respiratory infections was associated with the severity of asthma exacerbation (P > .15 for all). During peak HRV season in the winter of 2007 to 2008, this virus was detected in 46.4% of children with asthma exacerbations. Conclusions Respiratory viral infections are commonly found in children with asthma exacerbation, with HRV being the most important pathogen in our patients. Respiratory viral infection is a triggering factor for asthma exacerbation but does not correlate with its severity. url: https://doi.org/10.1378/chest.09-1250 doi: 10.1378/chest.09-1250 id: cord-321989-1enjopig author: Li, Yanpeng title: Metagenomic analysis identified co-infection with human rhinovirus C and bocavirus 1 in an adult suffering from severe pneumonia date: 2017-10-31 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: • We first present a HRV-C and HBoV1 co-infection in an adult woman with severe acute respiratory distress syndrome. • Our study suggests that HBoV1 co-infection might worsen the disease caused by HRV-C infection, and raises a question whether HRV-C-related severe pneumonia is often associated with co-infection of other respiratory viruses such as bocavirus. url: https://www.sciencedirect.com/science/article/pii/S0163445317303420 doi: 10.1016/j.jinf.2017.10.012 id: cord-103367-fxvvndic author: Liu, N. title: Machine learning dimensionality reduction for heart rate n-variability (HRnV) based risk stratification of chest pain patients in the emergency department date: 2020-07-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background: Chest pain is among the most common presenting complaints in the emergency department (ED). Swift and accurate risk stratification of chest pain patients in the ED may improve patient outcomes and reduce unnecessary costs. Traditional logistic regression with stepwise variable selection has been used to build risk prediction models for ED chest pain patients. In this study, we aimed to investigate if machine learning dimensionality reduction methods can achieve superior performance than the stepwise approach in deriving risk stratification models. Methods: A retrospective analysis was conducted on the data of patients >20 years old who presented to the ED of Singapore General Hospital with chest pain between September 2010 and July 2015. Variables used included demographics, medical history, laboratory findings, heart rate variability (HRV), and HRnV parameters calculated from five to six-minute electrocardiograms (ECGs). The primary outcome was 30-day major adverse cardiac events (MACE), which included death, acute myocardial infarction, and revascularization. Candidate variables identified using univariable analysis were then used to generate the stepwise logistic regression model and eight machine learning dimensionality reduction prediction models. A separate set of models was derived by excluding troponin. Receiver operating characteristic (ROC) and calibration analysis was used to compare model performance. Results: 795 patients were included in the analysis, of which 247 (31%) met the primary outcome of 30-day MACE. Patients with MACE were older and more likely to be male. All eight dimensionality reduction methods marginally but non-significantly outperformed stepwise variable selection; The multidimensional scaling algorithm performed the best with an area under the curve (AUC) of 0.901. All HRnV-based models generated in this study outperformed several existing clinical scores in ROC analysis. Conclusions: HRnV-based models using stepwise logistic regression performed better than existing chest pain scores for predicting MACE, with only marginal improvements using machine learning dimensionality reduction. Moreover, traditional stepwise approach benefits from model transparency and interpretability; in comparison, machine learning dimensionality reduction models are black boxes, making them difficult to explain in clinical practice. url: http://medrxiv.org/cgi/content/short/2020.07.05.20146571v1?rss=1 doi: 10.1101/2020.07.05.20146571 id: cord-291238-myjyw8ei author: Longtin, Jean title: Rhinovirus Outbreaks in Long-term Care Facilities, Ontario, Canada date: 2010-09-17 words: 1635.0 sentences: 94.0 pages: flesch: 51.0 cache: ./cache/cord-291238-myjyw8ei.txt txt: ./txt/cord-291238-myjyw8ei.txt summary: Although the most commonly identifi ed viruses have been infl uenza virus and respiratory syncytial virus (RSV) (1), human rhinovirus (HRV) is being increasingly associated with severe respiratory disease and outbreaks in these facilities (2) (3) (4) (5) (6) . As a result, the number of outbreaks caused by HRV in long-term care facilities, and the associated illness and death, may be substantially underestimated. During the surveillance period, 297 respiratory disease outbreaks in long-term care facilities were reported to the Ontario Public Health Laboratory; we received samples from 269 facilities (Table 1) . We cautiously assume that HRV was the causative organism for 174 (59%) of the 297 respiratory outbreaks in long-term care facilities in Ontario during the surveillance period. Neighbor-joining phylogenetic tree of human rhinoviruses (HRV) isolated from 4 respiratory disease outbreaks with associated deaths in long-term care facilities, Ontario, Canada. abstract: Diagnostic difficulties may have led to underestimation of rhinovirus infections in long-term care facilities. Using surveillance data, we found that rhinovirus caused 59% (174/297) of respiratory outbreaks in these facilities during 6 months in 2009. Disease was sometimes severe. Molecular diagnostic testing can differentiate these outbreaks from other infections such as influenza. url: https://www.ncbi.nlm.nih.gov/pubmed/20735934/ doi: 10.3201/eid1609.100476 id: cord-016499-5iqpl23p author: Mackay, Ian M. title: Rhinoviruses date: 2014-02-27 words: 23394.0 sentences: 1156.0 pages: flesch: 45.0 cache: ./cache/cord-016499-5iqpl23p.txt txt: ./txt/cord-016499-5iqpl23p.txt summary: A convenience population of 15 healthy children (1-9 years old) without asthma were followed during at least three seasons, and picornaviruses were detected in 5 % of 740 specimens (21 % of infections) not associated with symptoms, The impact of HRV typing and of sampling based only on symptoms. Clinical features and complete genome characterization of a distinct human rhinovirus genetic cluster, probably representing a previously undetected HRV species, HRV-C, associated with acute respiratory illness in children Comparison of results of detection of rhinovirus by PCR and viral culture in human nasal wash specimens from subjects with and without clinical symptoms of respiratory illness Detection of human rhinovirus C viral genome in blood among children with severe respiratory infections in the Philippines abstract: Picornaviruses, which include the human rhinoviruses (HRVs) and enteroviruses (EVs), are the most frequent cause of acute human illness worldwide. HRVs are the most prevalent cause of acute respiratory tract illnesses (ARIs) which usually commence in the upper respiratory tract (URT). ARIs are the leading cause of morbidity in children under 5 years and occur in all seasons. ARIs linked to HRV infections are associated with excessive and perhaps inappropriate antibiotic prescribing and with significant direct and indirect healthcare expenditure. ARI incidence is highest in the first 2 years of life, with up to thirteen episodes per year including up to six positive for an HRV, and it is not uncommon to average one infection per child-month. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7120790/ doi: 10.1007/978-1-4899-7448-8_29 id: cord-351571-gwtkrt5u author: Mackay, Ian M. title: Community-Wide, Contemporaneous Circulation of a Broad Spectrum of Human Rhinoviruses in Healthy Australian Preschool-Aged Children During a 12-Month Period date: 2013-05-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Human rhinovirus (HRV) replication triggers exacerbation of asthma and causes most acute respiratory illnesses (ARIs), which may manifest as influenza-like illness. The recent assignment of 60 previously unknown HRV types to a third HRV species, Human rhinovirus C, raised questions about the prevalence of these picornavirus types in the community, the extent of HRV diversity at a single site, and whether the HRVs have an equally diverse clinical impact on their hosts. We quantified HRV diversity, and there was no clinical impact attributable to HRV species and genotypes among a community population of preschool-aged children with ARI who provided respiratory samples during 2003. All HRV species were represented among 138 children with ARI, and 74 distinct HRV types were cocirculating. Fever accompanied 32.8% of HRV-positive ARI cases. HRVs were less likely than DNA viruses to be codetected with another virus, suggesting virus interference at the community level, demonstrated by the inverse correlation between influenza virus detection and HRV detection. url: https://doi.org/10.1093/infdis/jis476 doi: 10.1093/infdis/jis476 id: cord-342993-deuytbml author: Maffey, Alberto F. title: Viruses and atypical bacteria associated with asthma exacerbations in hospitalized children date: 2010-05-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES AND WORKING HYPOTHESIS: To evaluate the prevalence of respiratory viruses Mycoplasma pneumoniae and Chlamydophila pneumoniae and gain insight into their seasonal circulation pattern in children with acute asthma exacerbations in a temperate southern hemisphere region. STUDY DESIGN: Patients hospitalized between 3 months and 16 years of age were included in a 1‐year prospective, observational, cross‐sectional study. Respiratory secretions were collected and the presence of different viruses and atypical bacteria analyzed by immunofluorescence and polymerase chain reaction. RESULTS: Two hundred nine patients (118 females) aged (mean ± SD) 4.4 ± 4 years were included. A potential causative agent was detected in 78% of the patients. The most frequently detected viruses were respiratory syncytial virus (HRSV) (n = 85; 40%) and rhinovirus (HRV) (n = 52; 24.5%); M. pneumoniae and C. pneumoniae were detected in 4.5% and 2% of the cases, respectively. Patients with HRSV (vs. HRV) were hospitalized for a longer time (6.7 vs. 5.2 days, P = 0.012), required more days of oxygen supply (5.1 vs. 3.4, P = 0.005), had a longer duration of the exacerbation before hospitalization (3.6 vs. 1.9 days, P = 0.001) and were younger (3.7 vs. 5.1 years, P = 0.012). Three peaks of admissions were observed. A first peak (early autumn) caused by HRV, a second peak (winter) caused mainly by HRSV and a third one (spring), caused by HRSV, an increase in HMPV together with a second outbreak of HRV. CONCLUSIONS: Children with an acute asthma exacerbation presented a high prevalence of respiratory viruses. Most hospitalizations corresponded to seasonal increases in prevalence of HRV and HRSV. Pediatr Pulmonol. 2010; 45:619–625. © 2010 Wiley‐Liss, Inc. url: https://doi.org/10.1002/ppul.21236 doi: 10.1002/ppul.21236 id: cord-307602-2cmgu7rf author: McErlean, P. title: Characterisation of a newly identified human rhinovirus, HRV-QPM, discovered in infants with bronchiolitis date: 2007-05-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Human rhinoviruses (HRVs) are some of the earliest identified and most commonly detected viruses associated with acute respiratory tract infections (ARTIs) and yet the molecular epidemiology and genomic variation of individual serotypes remains undefined. OBJECTIVES: To molecularly characterise a novel HRV and determine its prevalence and clinical impact on a predominantly paediatric population. STUDY DESIGN: Nucleotide sequencing was employed to determine the complete HRV-QPM coding sequence. Two novel real-time RT-PCR diagnostic assays were designed and employed to retrospectively screen a well-defined population of 1244 specimen extracts to identify the prevalence of HRV-QPM during 2003. RESULTS: Phylogenetic studies of complete coding sequences defined HRV-QPM as a novel member the genus Rhinovirus residing within the previously described HRV-A2 sub-lineage. Investigation of the relatively short VP1 sequence suggest that the virus is resistant to Pleconaril, setting it apart from the HRV A species. Sixteen additional HRV-QPM strains were detected (1.4% of specimens) often as the sole micro-organism present among infants with suspected bronchiolitis. HRV-QPM was also detected in Europe during 2006, and a closely related virus circulated in the United States during 2004. CONCLUSIONS: We present the molecular characterisation and preliminary clinical impact of a newly identified HRV along with sequences representing additional new HRVs. url: https://api.elsevier.com/content/article/pii/S1386653207001278 doi: 10.1016/j.jcv.2007.03.012 id: cord-325137-6c6er06a author: Moser, Lindsey A. title: A Universal Next-Generation Sequencing Protocol To Generate Noninfectious Barcoded cDNA Libraries from High-Containment RNA Viruses date: 2016-06-07 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Several biosafety level 3 and/or 4 (BSL-3/4) pathogens are high-consequence, single-stranded RNA viruses, and their genomes, when introduced into permissive cells, are infectious. Moreover, many of these viruses are select agents (SAs), and their genomes are also considered SAs. For this reason, cDNAs and/or their derivatives must be tested to ensure the absence of infectious virus and/or viral RNA before transfer out of the BSL-3/4 and/or SA laboratory. This tremendously limits the capacity to conduct viral genomic research, particularly the application of next-generation sequencing (NGS). Here, we present a sequence-independent method to rapidly amplify viral genomic RNA while simultaneously abolishing both viral and genomic RNA infectivity across multiple single-stranded positive-sense RNA (ssRNA+) virus families. The process generates barcoded DNA amplicons that range in length from 300 to 1,000 bp, which cannot be used to rescue a virus and are stable to transport at room temperature. Our barcoding approach allows for up to 288 barcoded samples to be pooled into a single library and run across various NGS platforms without potential reconstitution of the viral genome. Our data demonstrate that this approach provides full-length genomic sequence information not only from high-titer virion preparations but it can also recover specific viral sequence from samples with limited starting material in the background of cellular RNA, and it can be used to identify pathogens from unknown samples. In summary, we describe a rapid, universal standard operating procedure that generates high-quality NGS libraries free of infectious virus and infectious viral RNA. IMPORTANCE This report establishes and validates a standard operating procedure (SOP) for select agents (SAs) and other biosafety level 3 and/or 4 (BSL-3/4) RNA viruses to rapidly generate noninfectious, barcoded cDNA amenable for next-generation sequencing (NGS). This eliminates the burden of testing all processed samples derived from high-consequence pathogens prior to transfer from high-containment laboratories to lower-containment facilities for sequencing. Our established protocol can be scaled up for high-throughput sequencing of hundreds of samples simultaneously, which can dramatically reduce the cost and effort required for NGS library construction. NGS data from this SOP can provide complete genome coverage from viral stocks and can also detect virus-specific reads from limited starting material. Our data suggest that the procedure can be implemented and easily validated by institutional biosafety committees across research laboratories. url: https://www.ncbi.nlm.nih.gov/pubmed/27822536/ doi: 10.1128/msystems.00039-15 id: cord-001601-tsuz3j40 author: Ngan, Luong Thi My title: Antiviral Activity and Possible Mechanism of Action of Constituents Identified in Paeonia lactiflora Root toward Human Rhinoviruses date: 2015-04-10 words: 6157.0 sentences: 328.0 pages: flesch: 53.0 cache: ./cache/cord-001601-tsuz3j40.txt txt: ./txt/cord-001601-tsuz3j40.txt summary: An assessment was made of the antiviral activities and mechanisms of action of paeonol (PA) and 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG) from Paeonia lactiflora root toward HRV-2 and HRV-4 in MRC5 cells using a tetrazolium method and real-time quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay. These findings suggest that PGG and PA may block or reduce the entry of the viruses into the cells to protect the cells from the virus destruction and abate virus replication, which may play an important role in interfering with expressions of rhinovirus receptors (intercellular adhesion molecule-1 and low-density lipoprotein receptor), inflammatory cytokines (interleukin (IL)-6, IL-8, tumor necrosis factor, interferon beta, and IL-1β), and Toll-like receptor, which resulted in diminishing symptoms induced by HRV. In the presence of 100 μg/mL PA or 20 μg/mL PGG in MRC5 cell cultures infected with HRV-2, the RNA replication levels were reduced by 30.1 and 14.3 fold, respectively, compared to the levels in the cell cultures without the compounds (Fig 4A) . abstract: Human rhinoviruses (HRVs) are responsible for more than half of all cases of the common cold and cost billions of USD annually in medical visits and missed school and work. An assessment was made of the antiviral activities and mechanisms of action of paeonol (PA) and 1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose (PGG) from Paeonia lactiflora root toward HRV-2 and HRV-4 in MRC5 cells using a tetrazolium method and real-time quantitative reverse transcription polymerase chain reaction and enzyme-linked immunosorbent assay. Results were compared with those of a reference control ribavirin. Based on 50% inhibitory concentration values, PGG was 13.4 and 18.0 times more active toward HRV-2 (17.89 μM) and HRV-4 (17.33 μM) in MRC5 cells, respectively, than ribavirin. The constituents had relatively high selective index values (3.3–>8.5). The 100 μg/mL PA and 20 μg/mL PGG did not interact with the HRV-4 particles. These constituents inhibited HRV-4 infection only when they were added during the virus inoculation (0 h), the adsorption period of HRVs, but not after 1 h or later. Moreover, the RNA replication levels of HRVs were remarkably reduced in the MRC5 cultures treated with these constituents. These findings suggest that PGG and PA may block or reduce the entry of the viruses into the cells to protect the cells from the virus destruction and abate virus replication, which may play an important role in interfering with expressions of rhinovirus receptors (intercellular adhesion molecule-1 and low-density lipoprotein receptor), inflammatory cytokines (interleukin (IL)-6, IL-8, tumor necrosis factor, interferon beta, and IL-1β), and Toll-like receptor, which resulted in diminishing symptoms induced by HRV. Global efforts to reduce the level of synthetic drugs justify further studies on P. lactiflora root-derived materials as potential anti-HRV products or lead molecules for the prevention or treatment of HRV. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4393083/ doi: 10.1371/journal.pone.0121629 id: cord-023766-qx0qdjmt author: Nirwan, Sonam title: Rhinovirus RNA Polymerase: Structure, Function, and Inhibitors date: 2018-11-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Human rhinovirus is responsible for causing 50% of common cold infections in infants and adults. It belongs to the picornavirus family of nonenveloped positive-strand RNA viruses. The RNA synthesis of rhinovirus is carried out by RNA-dependent RNA polymerase, also known as 3D(Pol). It catalyzes the synthesis of negative-strand RNA using a positive-strand template. The structure of the enzyme consists of three domains: palm, fingers, and thumb domains and Mg(2+) in the active site. These conserved structural features of the enzyme help in catalyzing phosphodiester bond formation between the two consecutive nucleotide units complimentary to the template RNA using a VPg primer. Owing to the presence of over 100 serotypes of the enzyme, designing specific inhibitors targeting the polymerase is a challenging task and until now no clinically approved antirhino viral drug is reported. In this review, we have given detailed information about the structure and function of the enzyme and also discussed some of the inhibitors and their in vivo activity against 3D(Pol). url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173612/ doi: 10.1016/b978-0-12-815422-9.00011-5 id: cord-274943-fn3m14cn author: Philpott, Erin K title: Febrile Rhinovirus Illness During Pregnancy Is Associated With Low Birth Weight in Nepal date: 2017-04-06 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Adverse birth outcomes, including low birth weight (LBW), defined as <2500 grams, small-for-gestational-age (SGA), and prematurity, contribute to 60%–80% of infant mortality worldwide and may be related to infections during pregnancy. The aim of this study was to assess whether febrile human rhinovirus (HRV) illness is associated with adverse birth outcomes. METHODS: Active household-based weekly surveillance was performed for respiratory illness episodes in pregnant women as part of a community-based, prospective, randomized trial of maternal influenza immunization in rural Nepal. Rhinovirus (HRV) febrile illness episodes were defined as fever plus cough, sore throat, runny nose, and/or myalgia with HRV detected on mid-nasal swab. Multivariate regression analysis evaluated the association between febrile HRV respiratory illness and adverse birth outcomes. RESULTS: Overall, 96 (3%) of 3693 pregnant women had HRV-positive febrile respiratory illnesses. Infants born to pregnant women with HRV febrile illness had a 1.6-fold increased risk of being LBW compared with those with non-HRV febrile illness (28 of 96 [38%] vs 109 of 458 [24%]; relative risk [RR], 1.6; 95% confidence interval [CI], 1.1–2.3). No difference in risk of LBW was observed between infants born to mothers with non-HRV febrile respiratory illness and those without respiratory illness during pregnancy (109 of 458 [24%] vs 552 of 2220 [25%], respectively; RR, 1.0; 95% CI, 0.8–1.2). CONCLUSIONS: Febrile illness due to rhinovirus during pregnancy was associated with increased risk of LBW in a rural South Asian population. Interventions to reduce the burden of febrile respiratory illness due to rhinovirus during pregnancy may have a significant impact on LBW and subsequent infant mortality. url: https://www.ncbi.nlm.nih.gov/pubmed/28584855/ doi: 10.1093/ofid/ofx073 id: cord-317548-ft7lkpzq author: Proud, David title: Upper airway viral infections date: 2007-07-05 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Upper airway viral infections (URI) are a major cause of absence from school and work. Although morbidity is low in most of the subjects, the complications of URI, including otitis media, sinusitis and exacerbations of asthma and chronic obstructive pulmonary disease (COPD) have an enormous health impact. Despite the major health care consequences associated with these complications, our understanding of how URI trigger upper airway symptoms and cause exacerbations of lower airway diseases remains limited. This article reviews our current understanding of the pathogenesis of URI, and of viral exacerbations of asthma and COPD, and considers host defense parameters that may regulate susceptibility to disease exacerbations. We will also consider current and potential therapeutic approaches for the treatment of URI and their lower airway complications. url: https://www.sciencedirect.com/science/article/pii/S1094553907000521 doi: 10.1016/j.pupt.2007.06.004 id: cord-319942-ava86u8y author: Rady, Hanaa I. title: Prevalence of Human rhinovirus infection in young children with acute wheezing() date: 2018-05-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: INTRODUCTION: Recurrent wheezing is one of the leading causes of chronic illness in childhood. We aimed to evaluate the prevalence of Human Rhinovirus (HRV) infection in the acute attack of wheezy chest which began after a respiratory illness. METHODOLOGY: The study was conducted on 200 children aged 2 months to 5 years presenting to the emergency department with an acute wheezy episode either for the first time or recurrent wheeze defined as >2 reports of wheezing in the first 3 years of life. All subjects were subjected to a complete history and clinical examination. Chest X-ray was done to all subjects. Nasopharyngeal and oropharyngeal swabs were obtained from all subjects and the presence of HRV was determined by PCR examination. RESULTS: By PCR method, 163 patients (81.5%) were positive for viral infection. Due to viral co-infection, 49.5% (99 cases) were +ve for Respiratory Syncytial virus followed by HRV 43.5% (87 cases). CONCLUSION: HRV was the second common viral infection in children with wheezes. Its prevalence was more in winter with higher incidence of recurrence. Compared to the other respiratory viruses, it had the higher mortality 43.7%. url: https://www.sciencedirect.com/science/article/pii/S1110663818300314 doi: 10.1016/j.epag.2018.05.001 id: cord-002257-30s14h9j author: Ratnamohan, Vigneswary M. title: Phylogenetic analysis of human rhinoviruses collected over four successive years in Sydney, Australia date: 2016-08-09 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Human rhinoviruses (HRV) cause a wide spectrum of disease, ranging from a mild influenza‐like illness (ILI) to severe respiratory infection. Molecular epidemiological data are limited for HRV circulating in the Southern Hemisphere. OBJECTIVES: To identify the species and genotypes of HRV from clinical samples collected in Sydney, Australia, from 2006 to 2009. METHODS: Combined nose and throat swabs or nasopharyngeal aspirates collected from individuals with ILI were tested for HRV using real‐time reverse‐transcriptase polymerase chain reaction (RT‐PCR). Sequencing data of 5′UTR and VP4/VP2 coding regions on RT‐PCR‐positive specimens were analysed. RESULTS: Human rhinoviruses were detected by real‐time PCR in 20.9% (116/555) of samples tested. Phylogenetic analysis of 5′UTR and VP4/VP2 on HRV‐positive samples was concordant in the grouping of HRV A and B species but not HRV C species. Eighty per cent (16/20) of sequences that grouped as HRV C in the VP4/VP2 tree clustered as HRV A, alongside some previously described C strains as subspecies C/A. Discordant branching was seen within HRV A group: two sequences clustering as A in the VP4/VP2 tree branched within the C/A subspecies in the 5′UTR tree, and one sequence showed identity to different HRV A strains in the two genes. The prevalence of HRV C and C/A species was greater in paediatric compared to adult patients (47.9% vs 25.5%, P = .032). CONCLUSION: Human rhinoviruses are a common cause of respiratory infections, and HRV C is present in the Southern Hemisphere. Sequencing of multiple HRV regions may be necessary to determine exact phylogenetic relationships. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5059946/ doi: 10.1111/irv.12404 id: cord-007234-hcpa8ej5 author: Renwick, Neil title: A Recently Identified Rhinovirus Genotype Is Associated with Severe Respiratory-Tract Infection in Children in Germany date: 2007-12-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Acute respiratory infection is a significant cause of morbidity and mortality in children worldwide. Accurate identification of causative agents is critical to case management and to prioritization in vaccine development. Sensitive multiplex diagnostics provide us with an opportunity to investigate the relative contributions of individual agents andmayalso facilitate the discovery of new pathogens. Recently, application of MassTag polymerase chain reaction (PCR) to undiagnosed infuenza-like illness in New York State led to the discovery of a novel rhinovirus genotype. Here we report the investigation, by MassTag PCR, of pediatric respiratory-tract infections in Germany, studying 97 cases for which no pathogen was identified through routine laboratory evaluation. Respiratory viruses were identified in 49 cases (51%); of the 55 identified viruses, 41 (75%) were rhinoviruses. The novel genotype represented 73% of rhinoviruses and 55% of all identified viruses. Infections with the novel genotype were associated with upper-respiratory-tract symptoms but, more frequently, with bronchitis, bronchiolitis, and pneumonia. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109967/ doi: 10.1086/524312 id: cord-270892-ycc3csyh author: Rollinger, Judith M. title: The human rhinovirus: human‐pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery date: 2010-12-13 words: 19628.0 sentences: 1166.0 pages: flesch: 41.0 cache: ./cache/cord-270892-ycc3csyh.txt txt: ./txt/cord-270892-ycc3csyh.txt summary: [79] [80] [81] [82] Taken together, the results of natural cold studies as well as of experimental infection in human volunteers clearly demonstrate that HRV are able to replicate in the upper as well as in the lower airways. Such an anti-HRV drug would have to be (i) with broad spectrum activity because of the high number of HRV serotypes, (ii) administered very early in infection to demonstrate a good antiviral effect because of the fast infection kinetics, (iii) very safe because of the broad application by millions of people, and (iv) directed against a highly conserved target with low risk of resistance development. The HRV-induced CPE, infectious virus titers, viral protein expression, and RNA synthesis can be chosen as parameters to evaluate the anti-HRV activity of compounds in cell-culture based assays. Due to the lack of a small-animal model for HRV infection until 2008, the experimental human challenge model has to be used to approve effects of potential antiviral drugs under controlled conditions in preclinical studies. abstract: As the major etiological agent of the common cold, human rhinoviruses (HRV) cause millions of lost working and school days annually. Moreover, clinical studies proved an association between harmless upper respiratory tract infections and more severe diseases e.g. sinusitis, asthma, and chronic obstructive pulmonary disease. Both the medicinal and socio‐economic impact of HRV infections and the lack of antiviral drugs substantiate the need for intensive antiviral research. A common structural feature of the approximately 100 HRV serotypes is the icosahedrally shaped capsid formed by 60 identical copies of viral capsid proteins VP1‐4. The capsid protects the single‐stranded, positive sense RNA genome of about 7,400 bases in length. Both structural as well as nonstructural proteins produced during the viral life cycle have been identified as potential targets for blocking viral replication at the step of attachment, entry, uncoating, RNA and protein synthesis by synthetic or natural compounds. Moreover, interferon and phytoceuticals were shown to protect host cells. Most of the known inhibitors of HRV replication were discovered as a result of empirical or semi‐empirical screening in cell culture. Structure–activity relationship studies are used for hit optimization and lead structure discovery. The increasing structural insight and molecular understanding of viral proteins on the one hand and the advent of innovative computer‐assisted technologies on the other hand have facilitated a rationalized access for the discovery of small chemical entities with antirhinoviral (anti‐HRV) activity. This review will (i) summarize existing structural knowledge about HRV, (ii) focus on mechanisms of anti‐HRV agents from synthetic and natural origin, and (iii) demonstrate strategies for efficient lead structure discovery. © 2009 Wiley Periodicals, Inc. Med Res Rev, 31, No. 1, 42–92, 2010 url: https://doi.org/10.1002/med.20176 doi: 10.1002/med.20176 id: cord-275275-wy8d6cw3 author: Rovida, Francesca title: Molecular detection of gastrointestinal viral infections in hospitalized patients date: 2013-09-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Gastrointestinal viral syndromes are a common cause of morbidity and mortality in humans worldwide. Etiological agents include a large number of viruses encompassing several orders, families, and genera. During the period April 2011 to April 2012, 689 stool samples from as many patients hospitalized at the Fondazione IRCCS Policlinico San Matteo of Pavia exhibiting gastrointestinal syndromes were examined for the presence of rotavirus, norovirus, astrovirus, adenovirus, rhinovirus, enterovirus, parechovirus, bocavirus, coronavirus, sapovirus, cosavirus, and aichi virus using polymerase chain reaction assays. Gastrointestinal viral agents were detected in 246 (36%) patients of the 689 analyzed. Adenovirus and norovirus were the most common viruses in this cohort, while aichi virus was the only gastrointestinal agent not detected. Surprisingly, rhinovirus was one of the most frequently detected viruses. However, a potential association with gastroenteritis remains to be confirmed. url: https://www.ncbi.nlm.nih.gov/pubmed/24035383/ doi: 10.1016/j.diagmicrobio.2013.07.020 id: cord-015893-e0fofgxq author: Ryhal, Bruce title: Viral Disease, Air Pollutants, Nanoparticles, and Asthma date: 2011-05-03 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Health care providers who treat patients with respiratory disease are often asked by their patients, “What caused my asthma? And what causes my asthma suddenly to become worse?” These questions have always been difficult to answer, and moving directly to a discussion of the management of asthma is a much easier road to take. In recent years, though, enough information has accumulated about the causes of asthma that one can weave a story containing useful advice that may help patients participate in the management of their disease. And there are also recent studies that can provide answers to the questions posed by physicians who have watched in puzzlement as their previously well-controlled asthma patients have spiraled rapidly out of control. This story has been growing increasingly complex, with an ever-expanding cast of players that sometimes creates a tangled web of interactions. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7119993/ doi: 10.1007/978-1-4419-6836-4_11 id: cord-317499-mxt7stat author: Saraya, Takeshi title: Epidemiology of virus-induced asthma exacerbations: with special reference to the role of human rhinovirus date: 2014-05-26 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Viral respiratory infections may be associated with the virus-induced asthma in adults as well as children. Particularly, human rhinovirus is strongly suggested a major candidate for the associations of the virus-induced asthma. Thus, in this review, we reviewed and focused on the epidemiology, pathophysiology, and treatment of virus-induced asthma with special reference on human rhinovirus. Furthermore, we added our preliminary data regarding the clinical and virological findings in the present review. url: https://www.ncbi.nlm.nih.gov/pubmed/24904541/ doi: 10.3389/fmicb.2014.00226 id: cord-352273-sras8r5z author: Saraya, Takeshi title: The molecular epidemiology of respiratory viruses associated with asthma attacks: A single-center observational study in Japan date: 2017-10-20 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Few reports have described the significance of viral respiratory infections (VRIs) in exacerbation of asthma in adult patients. The aim of this study was to elucidate the profiles of VRIs in adult patients with asthma along with their molecular epidemiology. A cross-sectional observational study was conducted at Kyorin University Hospital from August 2012 to May 2015. To identify respiratory pathogens in inpatients and outpatients suffering from asthma attacks, RT-PCR/sequencing/phylogenetic analysis methods were applied alongside conventional microbiological methods. Phylogenetic and pairwise distance analyses of 10 viruses were performed. A total of 106 asthma attack patients enrolled in this study in both inpatient (n = 49) and outpatient (n = 57) settings. The total 106 respiratory samples were obtained from nasopharyngeal swab (n = 68) or sputum (n = 38). Among these, patients with virus alone (n = 39), virus and bacterial (n = 5), and bacterial alone (n = 5) were identified. The ratio of virus-positive patients in inpatient or outpatient to the total cases were 31.1% (n = 33) and 10.4% (n = 11), respectively. The frequency of virus-positive patients was significantly higher in inpatients (75.3%, n = 33) than in outpatients (19.3%, n = 11). Major VRIs included human rhinovirus (HRV) (n = 24), human metapneumovirus (hMPV) (n = 9), influenza virus (Inf-V) (n = 8), and respiratory syncytial virus (RSV) (n = 3) infections with seasonal variations. HRV-A and HRV-C were the most commonly detected viruses, with wide genetic divergence on phylogenetic analysis. Asthmatic exacerbations in adults are highly associated with VRIs such as HRV-A or HRV-C, hMPV, RSV, and Inf-V infections with seasonal variations and genetic divergence, but similar frequencies of VRIs occurred in asthma attack patients throughout the seasons. url: https://doi.org/10.1097/md.0000000000008204 doi: 10.1097/md.0000000000008204 id: cord-327701-1qgaxcqq author: Scott, E. M. title: Risk factors and patterns of household clusters of respiratory viruses in rural Nepal date: 2019-10-14 words: 4720.0 sentences: 215.0 pages: flesch: 42.0 cache: ./cache/cord-327701-1qgaxcqq.txt txt: ./txt/cord-327701-1qgaxcqq.txt summary: In a prospective longitudinal study utilizing intensive weekly home-based active surveillance to evaluate the household transmission of nine respiratory viruses in rural South Asia, initial infection in young children was associated with the greatest risk of symptomatic respiratory virus household transmission with spread to infants occurring in 45% of transmission events. A higher proportion of initial infection among this group resulted in secondary cases compared to other age groups, including school-age children and mothers, a finding confirmed in our multivariable model of transmission incidence. While a model of Kenya transmission data supports immunizing school-age children to diminish transmission of the virus to infants, our study suggests that in rural South Asia, preschool-age children are more likely to transmit respiratory viruses to other household members [38] . Our study of non-influenza respiratory virus transmission within households in rural Nepal highlights the importance of targeting preschool-age children to prevent the spread of respiratory viral illness. abstract: Viral pneumonia is an important cause of death and morbidity among infants worldwide. Transmission of non-influenza respiratory viruses in households can inform preventative interventions and has not been well-characterised in South Asia. From April 2011 to April 2012, household members of pregnant women enrolled in a randomised trial of influenza vaccine in rural Nepal were surveyed weekly for respiratory illness until 180 days after birth. Nasal swabs were tested by polymerase chain reaction for respiratory viruses in symptomatic individuals. A transmission event was defined as a secondary case of the same virus within 14 days of initial infection within a household. From 555 households, 825 initial viral illness episodes occurred, resulting in 79 transmission events. The overall incidence of transmission was 1.14 events per 100 person-weeks. Risk of transmission incidence was associated with an index case age 1–4 years (incidence rate ratio (IRR) 2.35; 95% confidence interval (CI) 1.40–3.96), coinfection as initial infection (IRR 1.94; 95% CI 1.05–3.61) and no electricity in household (IRR 2.70; 95% CI 1.41–5.00). Preventive interventions targeting preschool-age children in households in resource-limited settings may decrease the risk of transmission to vulnerable household members, such as young infants. url: https://www.ncbi.nlm.nih.gov/pubmed/31607271/ doi: 10.1017/s0950268819001754 id: cord-307333-n6jc0jy3 author: Selvaggi, Carla title: Interferon lambda 1–3 expression in infants hospitalized for RSV or HRV associated bronchiolitis date: 2014-01-02 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: OBJECTIVES: The airway expression of type III interferons (IFNs) was evaluated in infants hospitalized for respiratory syncytial virus (RSV) or rhinovirus (HRV) bronchiolitis. As an additional objective we sought to determine whether a different expression of IFN lambda 1–3 was associated with different harboring viruses, the clinical course of bronchiolitis or with the levels of well established IFN stimulated genes (ISGs), such as mixovirus resistance A (MxA) and ISG56. METHODS: The analysis was undertaken in 118 infants with RSV or HRV bronchiolitis. Nasopharyngeal washes were collected for virological studies and molecular analysis of type III IFN responses. RESULTS: RSV elicited higher levels of IFN lambda subtypes when compared with HRV. A similar expression of type III IFN was found in RSVA or RSVB infected infants and in those infected with HRVA or HRVC viruses. Results also indicate that IFN lambda 1 and IFN lambda 2–3 levels were correlated with each other and with MxA and ISG56-mRNAs. In addition, a positive correlation exists between the IFN lambda1 levels and the clinical score index during RSV infection. In particular, higher IFN lambda 1 levels are associated to an increase of respiratory rate. CONCLUSIONS: These findings show that differences in the IFN lambda 1–3 levels in infants with RSV or HRV infections are present and that the expression of IFN lambda 1 correlates with the severity of RSV bronchiolitis. url: https://api.elsevier.com/content/article/pii/S016344531300399X doi: 10.1016/j.jinf.2013.12.010 id: cord-005392-0pgcfk6b author: Sidoti, Francesca title: Development of a Quantitative Real-Time Nucleic Acid Sequence-Based Amplification Assay with an Internal Control Using Molecular Beacon Probes for Selective and Sensitive Detection of Human Rhinovirus Serotypes date: 2011-07-05 words: 3621.0 sentences: 167.0 pages: flesch: 41.0 cache: ./cache/cord-005392-0pgcfk6b.txt txt: ./txt/cord-005392-0pgcfk6b.txt summary: title: Development of a Quantitative Real-Time Nucleic Acid Sequence-Based Amplification Assay with an Internal Control Using Molecular Beacon Probes for Selective and Sensitive Detection of Human Rhinovirus Serotypes In this study, we developed the first quantitative real-time nucleic acid sequence-based amplification assay with an internal control using molecular beacon probes for selective and sensitive detection of human rhinovirus serotypes. Aim of this study was to develop the first quantitative real-time nucleic acid sequence-based amplification assay internally controlled using molecular beacon for selective and sensitive detection of HRV serotypes. To estimate the dynamic range of the real-time NASBA assay (range of concentrations over which the method performs in a linear manner with an acceptable level of trueness and precision), we used HRV standard dilutions from 10 8 copies/ll to 1 copy/ll. Evaluation of a real-time nucleic acid sequence-based amplification assay using molecular beacons for detection of human immunodeficiency virus type 1 abstract: Evidence demonstrating that human rhinovirus (HRV) disease is not exclusively limited to the upper airways and may cause lower respiratory complications, together with the frequency of HRV infections and the increasing number of immunocompromised patients underline the need for rapid and accurate diagnosis of HRV infections. In this study, we developed the first quantitative real-time nucleic acid sequence-based amplification assay with an internal control using molecular beacon probes for selective and sensitive detection of human rhinovirus serotypes. We described a simple method to accurately quantify RNA target by computing the time to positivity (TTP) values for HRV RNA. Quantification capacity was assessed by plotting these TTP values against the starting number of target molecules. By using this simple method, we have significantly increased the diagnostic accuracy, precision, and trueness of real-time NASBA assay. Specificity of the method was verified in both in silico and experimental studies. Moreover, for assessment of clinical reactivity of the assay, NASBA has been validated on bronchoalveolar lavage (BAL) specimens. Our quantitative NASBA assay was found to be very specific, accurate, and precise with high repeatability and reproducibility. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7091405/ doi: 10.1007/s12033-011-9432-4 id: cord-281158-vjh9z7l4 author: Storch, Gregory A title: Respiratory Viruses in Babies: Important Insights From Down Under date: 2018-02-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: nan url: https://doi.org/10.1093/infdis/jix600 doi: 10.1093/infdis/jix600 id: cord-009773-pbm2vs5h author: TRIGG, C. J. title: Bronchial inflammation and the common cold: a comparison of atopic and non‐atopic individuals date: 2006-04-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background Cold virus infections are associated with asthma attacks and with increased bronchial responsiveness even in normal subjects. Possible mechanisms include epithelial damage, interaction with adhesion molecules or with T‐helper cell subsets. Objective To determine whether colds increase lower airway inflammation, comparing atopic with non‐atopic normal subjects. Methods Thirty healthy volunteers (15 atopic) took part. Basehne tests included viral serology. microbiological culture and polymerase chain reaction for rhinovirus infection (HRV‐PCR), histamine bronchial provocation and bronchoscopy. Twenty subjects (eight atopic) underwent repeat tests when they developed a cold. Results Forced expiratory volume in one second (FEV(1)) was significantly lower during colds (‐0.19L [95% confidence mterval ‐0.10, ‐0.29], P= 0,0004) and there was a significant increase in bronchial responsiveness (+0.62 doublings of the dose‐response slope [+0.24, +1.00], P=0.003). Eight subjects (two atopic) had a diagnosed viral infection: two HRV. three coronavirus (HCV), one HRV + HCV, one parainfluenza III(PI) and one respiratory syncytial virus (RSV) (also Haemophilus influenzae). In biopsies, during colds, total eosinophils (EG1(+)) increased significantly (geometric mean 6.73‐fold [1.12,40.46], P=O.04). Activated eosinophils (EG2(+)) only increased significantly in the subgroup without diagnosed viral infection and particularly in atopic rhinitics. T‐suppressor (CD8(+)) cells also increased significantly (median +178.3 cells mm(2), P= 0.004). Epithelial expression of intercellular adhesion molecule‐1 (ICAM‐1) expression increased in four atopic rhinitics during colds. Bronchial washings showed a significant increase in neutrophils (GM 1.53‐fold [1.04,2.25], P= 0.02). Conclusion Lower airway inflammation was present in atopic and non‐atopic normal subjects with colds. Atopic subjects differed in that they were less likely to have positive virological tests and were more likely to show activated eosinophilia in the lower airway, despite a similar spectrum of symptoms. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164830/ doi: 10.1111/j.1365-2222.1996.tb00593.x id: cord-253564-3y1wdepc author: Traves, Suzanne L title: Viral-associated exacerbations of asthma and COPD date: 2007-03-21 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Exacerbations of asthma and chronic obstructive pulmonary disease are major burdens on the healthcare system, and contribute significantly to the mortality and morbidity associated with these diseases. Upper respiratory viral infections are associated with the majority of such disease exacerbations. The past few years have seen advances in the mechanisms by which viral infections induce pro-inflammatory chemokine production, and in our understanding of host antiviral and anti-inflammatory defence pathways that might regulate responses to infection. A more comprehensive understanding of the molecular basis of these processes could elucidate new therapeutic approaches to reduce the devastating impact that these exacerbations have on quality of life and healthcare costs. url: https://api.elsevier.com/content/article/pii/S1471489207000495 doi: 10.1016/j.coph.2006.11.010 id: cord-284889-hth8nf5b author: Tsukagoshi, Hiroyuki title: Molecular epidemiology of respiratory viruses in virus-induced asthma date: 2013-09-12 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Acute respiratory illness (ARI) due to various viruses is not only the most common cause of upper respiratory infection in humans but is also a major cause of morbidity and mortality, leading to diseases such as bronchiolitis and pneumonia. Previous studies have shown that respiratory syncytial virus (RSV), human rhinovirus (HRV), human metapneumovirus (HMPV), human parainfluenza virus (HPIV), and human enterovirus infections may be associated with virus-induced asthma. For example, it has been suggested that HRV infection is detected in the acute exacerbation of asthma and infection is prolonged. Thus it is believed that the main etiological cause of asthma is ARI viruses. Furthermore, the number of asthma patients in most industrial countries has greatly increased, resulting in a morbidity rate of around 10-15% of the population. However, the relationships between viral infections, host immune response, and host factors in the pathophysiology of asthma remain unclear. To gain a better understanding of the epidemiology of virus-induced asthma, it is important to assess both the characteristics of the viruses and the host defense mechanisms. Molecular epidemiology enables us to understand the pathogenesis of microorganisms by identifying specific pathways, molecules, and genes that influence the risk of developing a disease. However, the epidemiology of various respiratory viruses associated with virus-induced asthma is not fully understood. Therefore, in this article, we review molecular epidemiological studies of RSV, HRV, HPIV, and HMPV infection associated with virus-induced asthma. url: https://doi.org/10.3389/fmicb.2013.00278 doi: 10.3389/fmicb.2013.00278 id: cord-345817-rrf3dbnb author: WOOD, Lisa G. title: Persistence of rhinovirus RNA and IP‐10 gene expression after acute asthma date: 2011-01-27 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Background and objective: Viral nucleic acid may be detected for up to 6 months after an acute asthma deterioration, but the pattern and consequences of viral persistence after acute asthma are incompletely understood. This study investigates the frequency of viral persistence after acute asthma, assesses viral infectivity and determines the host inflammatory responses to viral persistence. Methods: Adults and children presenting to hospital with acute asthma and a confirmed respiratory virus infection were studied acutely and at recovery 4–6 weeks later by clinical evaluation and induced sputum for viral and inflammatory mediator detection. Results: Viral RNA was detected during both acute asthma and recovery visits in 17 subjects (viral persistence), whereas in 22 subjects viral RNA had cleared by recovery (viral clearance). The following viruses were detected at recovery: human rhinovirus: 16; respiratory syncytial virus: 2; influenza: 2. In subjects with viral persistence, eight isolates were different to the virus detected at Visit 1. Forty‐four per cent of the human rhinovirus isolates were infective at recovery. Asthma and infection severity were similar in the viral clearance and viral persistence groups. Viral persistence was associated with elevated IL‐10 mRNA and inducible protein‐10 gene expression. Conclusions: Respiratory viral detection after acute asthma is common, and most often persistence is with non‐infective human rhinovirus. There is a host inflammatory response with an altered cytokine environment, and the viral RNA can be source of persistent infection. These effects may have longer‐term consequences in asthma. url: https://www.ncbi.nlm.nih.gov/pubmed/21054674/ doi: 10.1111/j.1440-1843.2010.01897.x id: cord-018421-wy3mtafh author: Waghmare, Alpana title: Rhinovirus, Coronavirus, Enterovirus, and Bocavirus After Hematopoietic Cell Transplantation or Solid Organ Transplantation date: 2016-02-15 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Respiratory viral infections represent a significant cause of morbidity and mortality in immunocompromised hosts. Newer molecular detection assays have allowed for the characterization of several respiratory viruses not previously recognized as having significant clinical impact in the immunocompromised population. Human rhinoviruses are the most common respiratory viruses detected in the upper respiratory tract of hematopoietic cell transplant and lung transplant recipients, and evidence on the impact on clinical outcomes is mounting. Other respiratory viruses including enteroviruses (EVs), coronaviruses (CoVs), and bocavirus may also contribute to pulmonary disease; however, data is limited in the immunocompromised population. Further studies are needed to define the epidemiology, risk factors, and clinical outcomes of these infections; this data will help inform decisions regarding development of antiviral therapy and infection prevention strategies. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7123292/ doi: 10.1007/978-3-319-28797-3_32 id: cord-269922-ddpud48b author: Waghmare, Alpana title: Human Rhinovirus Infections in Hematopoietic Cell Transplant Recipients: Risk Score for Progression to Lower Respiratory Tract Infection date: 2018-12-08 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Human rhinovirus lower respiratory tract infection (LRTI) is associated with mortality after hematopoietic cell transplantation (HCT); however, risk factors for LRTI are not well characterized. We sought to develop a risk score for progression to LRTI from upper respiratory tract infection (URTI) in HCT recipients. Risk factors for LRTI within 90 days were analyzed using Cox regression among HCT recipients with rhinovirus URTI between January 2009 and March 2016. The final multivariable model included factors with a meaningful effect on the bootstrapped optimism corrected concordance statistic. Weighted score contributions based on hazard ratios were determined. Cumulative incidence curves estimated the probability of LRTI at various score cut-offs. Of 588 rhinovirus URTI events, 100 (17%) progressed to LRTI. In a final multivariable model allogeneic grafts, prior rhinovirus URTI, low lymphocyte count, low albumin, positive cytomegalovirus serostatus, recipient statin use, and steroid use ≥2 mg/kg/day were associated with progression to LRTI. A weighted risk score cut-off with the highest sensitivity and specificity was determined. Risk scores above this cut-off were associated with progression to LRTI (cumulative incidence 28% versus 11% below cut-off; P < .001). The weighted risk score for progression to rhinovirus LRTI can help identify and stratify patients for clinical management and for future clinical trials of therapeutics in HCT recipients. url: https://api.elsevier.com/content/article/pii/S1083879118308048 doi: 10.1016/j.bbmt.2018.12.005 id: cord-299537-lbx1plqx author: Wang, Wei title: Molecular monitoring of causative viruses in child acute respiratory infection in endemo-epidemic situations in Shanghai date: 2010-09-19 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Numerous viruses are responsible for respiratory infections; however, both their distribution and genetic diversity, in a limited area and a population subgroup, have been studied only rarely during a sustained period of time. METHODS: A 2-year surveillance program of children presenting with acute respiratory infections (ARIs) was carried out to characterize the viral etiology and to assess whether using gene amplification and sequencing could be a reliable approach to monitor virus introduction and spread in a population subgroup. RESULTS: Using multiplex RT-PCR, 15 different respiratory viruses were detected within the 486 nasopharyngeal positive samples collected among 817 children aged <9-year old who presented with ARI during October 2006 to September 2008. A single virus was detected in 373 patients (45.7%), and two to four viruses in 113 patients (13.8%). The most frequent causative viruses were respiratory syncytial virus (RSV) (24.7%), human bocavirus (24.5%), and human rhinovirus (HRV) (15%). RSV was more prevalent in winter and among young infants. Cases of seasonal influenza A and B viruses were reported mainly in January and August. An increase in adenovirus infection was observed during the spring of the second year of the study. Sequence analyses showed multiple introductions of different virus subtypes and identified a high prevalence of the newly defined HRV-C species. A higher viral incidence was observed during the winter of 2008, which was unusually cold. CONCLUSIONS: This study supports the usefulness of multiplex RT-PCR for virus detection and co-infection, and for implementation of a molecular monitoring system for endemic and epidemic viral respiratory infections. url: https://www.ncbi.nlm.nih.gov/pubmed/20855230/ doi: 10.1016/j.jcv.2010.08.005 id: cord-324216-ce3wa889 author: Wang, Zheng title: Resequencing microarray probe design for typing genetically diverse viruses: human rhinoviruses and enteroviruses date: 2008-12-01 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: BACKGROUND: Febrile respiratory illness (FRI) has a high impact on public health and global economics and poses a difficult challenge for differential diagnosis. A particular issue is the detection of genetically diverse pathogens, i.e. human rhinoviruses (HRV) and enteroviruses (HEV) which are frequent causes of FRI. Resequencing Pathogen Microarray technology has demonstrated potential for differential diagnosis of several respiratory pathogens simultaneously, but a high confidence design method to select probes for genetically diverse viruses is lacking. RESULTS: Using HRV and HEV as test cases, we assess a general design strategy for detecting and serotyping genetically diverse viruses. A minimal number of probe sequences (26 for HRV and 13 for HEV), which were potentially capable of detecting all serotypes of HRV and HEV, were determined and implemented on the Resequencing Pathogen Microarray RPM-Flu v.30/31 (Tessarae RPM-Flu). The specificities of designed probes were validated using 34 HRV and 28 HEV strains. All strains were successfully detected and identified at least to species level. 33 HRV strains and 16 HEV strains could be further differentiated to serotype level. CONCLUSION: This study provides a fundamental evaluation of simultaneous detection and differential identification of genetically diverse RNA viruses with a minimal number of prototype sequences. The results demonstrated that the newly designed RPM-Flu v.30/31 can provide comprehensive and specific analysis of HRV and HEV samples which implicates that this design strategy will be applicable for other genetically diverse viruses. url: https://www.ncbi.nlm.nih.gov/pubmed/19046445/ doi: 10.1186/1471-2164-9-577 id: cord-000374-gt2pwc9b author: Yang, Albert C. title: Clustering Heart Rate Dynamics Is Associated with β-Adrenergic Receptor Polymorphisms: Analysis by Information-Based Similarity Index date: 2011-05-04 words: 5304.0 sentences: 279.0 pages: flesch: 43.0 cache: ./cache/cord-000374-gt2pwc9b.txt txt: ./txt/cord-000374-gt2pwc9b.txt summary: With these considerations in mind, in the present study, we introduce a bottom-up genotype-phenotype analysis to investigate the association between genetic polymorphisms and autonomic control of heart rate dynamics, using three common polymorphisms in genes encoding b-adrenergic receptor (b-AR) as an example. The analyses of the present study were two-fold: 1) a nonrandomness index [17] derived from the IBS method was applied to quantify the nonlinear aspect of HRV according to b-AR genotype and to test the correlation of this index with standard HRV indices; and 2) using agglomerative hierarchical cluster analysis, we unsupervisedly categorized these subjects into clusters based on pairwise dissimilarity among heart rate dynamics, and then we investigated the association of these clustering patterns with b-AR gene polymorphisms. The data presented in this study demonstrate a significant association of a common b 2 -AR polymorphism, Arg16Gly, with the non-randomness index, a nonlinear HRV measure derived from the IBS method. abstract: BACKGROUND: Genetic polymorphisms in the gene encoding the β-adrenergic receptors (β-AR) have a pivotal role in the functions of the autonomic nervous system. Using heart rate variability (HRV) as an indicator of autonomic function, we present a bottom-up genotype–phenotype analysis to investigate the association between β-AR gene polymorphisms and heart rate dynamics. METHODS: A total of 221 healthy Han Chinese adults (59 males and 162 females, aged 33.6±10.8 years, range 19 to 63 years) were recruited and genotyped for three common β-AR polymorphisms: β(1)-AR Ser49Gly, β(2)-AR Arg16Gly and β(2)-AR Gln27Glu. Each subject underwent two hours of electrocardiogram monitoring at rest. We applied an information-based similarity (IBS) index to measure the pairwise dissimilarity of heart rate dynamics among study subjects. RESULTS: With the aid of agglomerative hierarchical cluster analysis, we categorized subjects into major clusters, which were found to have significantly different distributions of β(2)-AR Arg16Gly genotype. Furthermore, the non-randomness index, a nonlinear HRV measure derived from the IBS method, was significantly lower in Arg16 homozygotes than in Gly16 carriers. The non-randomness index was negatively correlated with parasympathetic-related HRV variables and positively correlated with those HRV indices reflecting a sympathovagal shift toward sympathetic activity. CONCLUSIONS: We demonstrate a bottom-up categorization approach combining the IBS method and hierarchical cluster analysis to detect subgroups of subjects with HRV phenotypes associated with β-AR polymorphisms. Our results provide evidence that β(2)-AR polymorphisms are significantly associated with the acceleration/deceleration pattern of heart rate oscillation, reflecting the underlying mode of autonomic nervous system control. url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3087751/ doi: 10.1371/journal.pone.0019232 id: cord-278438-bnjkmegh author: Yuan, Lijuan title: Induction of mucosal immune responses and protection against enteric viruses: rotavirus infection of gnotobiotic pigs as a model date: 2002-09-10 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Enteric viruses are a major cause of diarrhea in animals and humans. Among them, rotaviruses are one of the most important causes of diarrhea in young animals and human infants. A lack of understanding of mechanisms to induce intestinal immunity and the correlates of protective immunity in neonates has impaired development of safe and effective vaccines against enteric viruses. Studies of candidate vaccines using an adult mouse model of subclinical enteric viral infections often do not predict vaccine efficacy against disease evaluated in neonatal large animals. A series of studies have been conducted using a neonatal gnotobiotic pig model of rotavirus infection and diarrhea to identify correlates of protective immunity and to evaluate traditional and novel vaccine approaches for the induction of mucosal immune responses and protection to enteric viruses. Gnotobiotic pigs recovered from infection with virulent Wa human rotavirus (HRV) (mimic natural infection) had high numbers of intestinal IgA rotavirus-specific primary antibody-secreting cells (ASCs) and memory B-cells (to recall antigen) measured by ELISPOT assay, which correlated with complete protection against rotavirus challenge. Most short-term IgA memory B-cells were resident in the ileum, the major site of rotavirus replication. Spleen, not the bone marrow, was the major resident site for longer-term IgG memory B-cells. Candidate rotavirus vaccines evaluated in pigs for their ability to induce intestinal or systemic ASC and protection against rotavirus infection and diarrhea included attenuated live virus, inactivated virus, and baculovirus-expressed double-layered rotavirus-like particles (2/6-VLPs). In combination with those candidate vaccines, various adjuvants, delivery systems, and immunization routes were tested, including incomplete Freund’s adjuvant for i.m. immunization, and a mutant Escherichia coli heat labile enterotoxin R192G (mLT) for i.n. immunization. It was shown that orally administered replicating vaccines were most effective for priming for intestinal IgA ASC and memory B-cell responses, but i.n. administered non-replicating 2/6-VLPs plus mLT were effective as booster vaccines. We conclude that protective immunity depends on the magnitude, location, viral protein-specificity, and isotype of the antibody responses induced by vaccination. Therefore highly effective enteric viral vaccines should: (i) induce sufficient levels of intestinal IgA antibodies; (ii) include viral antigens that induce neutralizing antibodies; and (iii) require the use of effective mucosal adjuvants or antigen delivery systems for non-replicating oral or i.n. vaccines. url: https://www.ncbi.nlm.nih.gov/pubmed/12072229/ doi: 10.1016/s0165-2427(02)00046-6 id: cord-336713-if6f58ii author: Yuan, Lijuan title: Short-term immunoglobulin A B-cell memory resides in intestinal lymphoid tissues but not in bone marrow of gnotobiotic pigs inoculated with Wa human rotavirus date: 2001-06-01 words: 7543.0 sentences: 367.0 pages: flesch: 56.0 cache: ./cache/cord-336713-if6f58ii.txt txt: ./txt/cord-336713-if6f58ii.txt summary: To investigate the development and sites of residence of intestinal memory B cells, and their role in protective immunity to reinfection with an enteric virus, we assessed the association between memory B cell and antibody-secreting cell (ASC) responses and protection using a gnotobiotic pig model for human rotavirus (HRV) infection and diarrhoea. The isotypes, quantities and tissue distribution of rotavirus-specific memory B cells and ASC were evaluated prechallenge (28 and 83 postinoculation days [PID]) and postchallenge (7 postchallenge days [PCD]), using enzyme-linked immunospot (ELISPOT) assay, in gnotobiotic pigs inoculated once with virulent or three times with attenuated HRV and challenged at PID 28 with the corresponding virulent HRV. In previous studies, 3, 4 we reported that the number of rotavirus-speci®c immunoglobulin A (IgA) antibody-secreting cells (ASC) present in the intestinal lamina propria of gnotobiotic pigs at the time of challenge (primary ASC) correlates with protection against infection and diarrhoea when challenged with human rotavirus (HRV). abstract: Immunological memory is important for protecting the host from reinfection. To investigate the development and sites of residence of intestinal memory B cells, and their role in protective immunity to reinfection with an enteric virus, we assessed the association between memory B cell and antibody-secreting cell (ASC) responses and protection using a gnotobiotic pig model for human rotavirus (HRV) infection and diarrhoea. The isotypes, quantities and tissue distribution of rotavirus-specific memory B cells and ASC were evaluated prechallenge (28 and 83 postinoculation days [PID]) and postchallenge (7 postchallenge days [PCD]), using enzyme-linked immunospot (ELISPOT) assay, in gnotobiotic pigs inoculated once with virulent or three times with attenuated HRV and challenged at PID 28 with the corresponding virulent HRV. Complete protection against HRV shedding and diarrhoea was associated with significantly higher numbers of immunoglobulin A (IgA) and immunoglobulin G (IgG) memory B cells and ASC in the ileum of virulent HRV-inoculated pigs at challenge. In contrast, pigs inoculated with attenuated HRV had lower numbers of IgA and IgG memory B cells and ASC in intestinal lymphoid tissues, but higher numbers in the spleen. The bone marrow had the lowest mean numbers of IgA and IgG memory B cells and ASC prechallenge in both groups of HRV-inoculated pigs. Therefore, bone marrow was not a site for IgA and IgG rotavirus-specific antibody production or for memory B cells after inoculation with live rotavirus, from 28 PID up to at least 83 PID. The effect of in vitro antigen dose was examined and it was determined to play an important role in the development of ASC from memory B cells for the different tissues examined. url: https://www.ncbi.nlm.nih.gov/pubmed/11412306/ doi: 10.1046/j.1365-2567.2001.01229.x id: cord-356027-ckdx56j1 author: Zheng, Shou-Yan title: Association between secondary thrombocytosis and viral respiratory tract infections in children date: 2016-03-11 words: nan sentences: nan pages: flesch: nan cache: txt: summary: abstract: Secondary thrombocytosis (ST) is frequently observed in children with a variety of clinical conditions. The leading cause of ST is respiratory tract infection (RTI) in children. Nasopharyngeal aspirate samples were collected and assessed for common respiratory viruses. The relationships between virus infections and secondary thrombocytosis were analyzed retrospectively. The blood platelet count and the presence of respiratory viruses were determined for 3156 RTI patients, and 817 (25.9%) cases with platelet ≥500 × 10(9)/L were considered as the thrombocytosis group. Compared with the normal group, the detection rates of respiratory syncytial virus (RSV) and human rhinovirus (HRV) were significantly higher in the thrombocytosis group (P = 0.017 and 0.042, respectively). HRV single infection was a risk factor associated with thrombocytosis [odds ratio (OR) = 1.560, 95% confidence interval (CI) = 1.108–2.197]. Furthermore, ST was more likely to occur in younger patients who had clinical manifestations of wheezing and dyspnea and who had been diagnosed with bronchiolitis. Furthermore, the course of disease lasted longer in these patients. ST is associated with viral respiratory tract infections, especially RSV and HRV infections. HRV single infection is a risk factor associated with thrombocytosis. url: https://www.ncbi.nlm.nih.gov/pubmed/26965460/ doi: 10.1038/srep22964 id: cord-318016-987w5i6t author: de Almeida, Marina B. title: Rhinovirus C and Respiratory Exacerbations in Children with Cystic Fibrosis date: 2010-06-17 words: 1848.0 sentences: 101.0 pages: flesch: 45.0 cache: ./cache/cord-318016-987w5i6t.txt txt: ./txt/cord-318016-987w5i6t.txt summary: To investigate a possible role for human rhinovirus C in respiratory exacerbations of children with cystic fibrosis, we conducted microbiologic testing on respiratory specimens from 103 such patients in São Paulo, Brazil, during 2006–2007. To investigate a possible role for human rhinovirus C in respiratory exacerbations of children with cystic fi brosis, we conducted microbiologic testing on respiratory specimens from 103 such patients in São Paulo, Brazil, during 2006-2007. In the study reported here, we obtained samples from patients during routine visits and exacerbations, which enabled us to identify a distinct role of different HRV subtypes. (3) , in which they used real-time nucleic acid sequence-based amplifi cation in conjunction with molecular markers to investigate the presence of 9 respiratory viruses in children with CF, described an association of viral infections with respiratory exacerbations, particularly those caused by infl uenza A, infl uenza B, and rhinovirus (3). abstract: To investigate a possible role for human rhinovirus C in respiratory exacerbations of children with cystic fibrosis, we conducted microbiologic testing on respiratory specimens from 103 such patients in São Paulo, Brazil, during 2006–2007. A significant association was found between the presence of human rhinovirus C and respiratory exacerbations. url: https://doi.org/10.3201/eid1606.100063 doi: 10.3201/eid1606.100063 id: cord-010075-72jodunj author: nan title: Paediatric SIG: Poster Session date: 2011-03-21 words: 32008.0 sentences: 1913.0 pages: flesch: 56.0 cache: ./cache/cord-010075-72jodunj.txt txt: ./txt/cord-010075-72jodunj.txt summary: Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169206/ doi: 10.1111/j.1440-1843.2011.01937_12.x id: cord-023298-ysur3sjq author: nan title: Respiratory Nurses SIG: Poster Session date: 2011-03-21 words: 32008.0 sentences: 1914.0 pages: flesch: 56.0 cache: ./cache/cord-023298-ysur3sjq.txt txt: ./txt/cord-023298-ysur3sjq.txt summary: Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169078/ doi: 10.1111/j.1440-1843.2011.01937_16.x id: cord-023302-p9pxz44a author: nan title: Cystic Fibrosis SIG: Poster Session date: 2011-03-21 words: 32008.0 sentences: 1915.0 pages: flesch: 56.0 cache: ./cache/cord-023302-p9pxz44a.txt txt: ./txt/cord-023302-p9pxz44a.txt summary: Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169099/ doi: 10.1111/j.1440-1843.2011.01937_7.x id: cord-023305-5lb9kho6 author: nan title: Oliv SIG: Poster Session date: 2011-03-21 words: 32008.0 sentences: 1916.0 pages: flesch: 56.0 cache: ./cache/cord-023305-5lb9kho6.txt txt: ./txt/cord-023305-5lb9kho6.txt summary: Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169107/ doi: 10.1111/j.1440-1843.2011.01937_11.x id: cord-023314-rwjxk8v4 author: nan title: Asthma & Allergy SIG: Poster Session 1 date: 2011-03-21 words: 32009.0 sentences: 1912.0 pages: flesch: 56.0 cache: ./cache/cord-023314-rwjxk8v4.txt txt: ./txt/cord-023314-rwjxk8v4.txt summary: Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169157/ doi: 10.1111/j.1440-1843.2011.01937_1.x id: cord-023333-b7w9zrl6 author: nan title: Oeld/Population Health SIG: Poster Session date: 2011-03-21 words: 32009.0 sentences: 1914.0 pages: flesch: 56.0 cache: ./cache/cord-023333-b7w9zrl6.txt txt: ./txt/cord-023333-b7w9zrl6.txt summary: Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169216/ doi: 10.1111/j.1440-1843.2011.01937_10.x id: cord-023343-y17z9w2x author: nan title: COPD SIG: Poster Session 1 date: 2011-03-21 words: 32008.0 sentences: 1910.0 pages: flesch: 55.0 cache: ./cache/cord-023343-y17z9w2x.txt txt: ./txt/cord-023343-y17z9w2x.txt summary: Expression of MR, CD91 and CD31 were decreased in patients with NEA or COPD, but not signifi cantly changed in EA Conclusion Impaired sputum-macrophage phagocytosis of apoptotic cells in NEA is associated with reduced expression of key macrophage recognition molecules. Conclusions Subjects with severe persistent asthma have an eating pattern of lower diet quality with higher intakes of fat and lower intakes of fi bre than healthy controls, which is related to lower lung function and increased airway infl ammation. Support and Confl ict of Interest Nil. Methods We performed a retrospective chart review of all adult patients who had an ICC over a 24-month period within a tertiary hospital respiratory service. The objectives of our study were to (1) determine the point prevalence and identify viruses associated with exacerbations and (2) evaluate clinical and investigational differences between viral infection positive and negative exacerbations in children with non-CF bronchiectasis. abstract: nan url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7169240/ doi: 10.1111/j.1440-1843.2011.01937_5.x ==== make-pages.sh questions [ERIC WAS HERE] ==== make-pages.sh search /data-disk/reader-compute/reader-cord/bin/make-pages.sh: line 77: /data-disk/reader-compute/reader-cord/tmp/search.htm: No such file or directory Traceback (most recent call last): File "/data-disk/reader-compute/reader-cord/bin/tsv2htm-search.py", line 51, in with open( TEMPLATE, 'r' ) as handle : htm = handle.read() FileNotFoundError: [Errno 2] No such file or directory: '/data-disk/reader-compute/reader-cord/tmp/search.htm' ==== make-pages.sh topic modeling corpus Zipping study carrel