id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270892-ycc3csyh	Rollinger, Judith M.	The human rhinovirus: human‐pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery	2010-12-13		.txt	text/plain	19628	1166	41	[79] [80] [81] [82] Taken together, the results of natural cold studies as well as of experimental infection in human volunteers clearly demonstrate that HRV are able to replicate in the upper as well as in the lower airways. Such an anti-HRV drug would have to be (i) with broad spectrum activity because of the high number of HRV serotypes, (ii) administered very early in infection to demonstrate a good antiviral effect because of the fast infection kinetics, (iii) very safe because of the broad application by millions of people, and (iv) directed against a highly conserved target with low risk of resistance development. The HRV-induced CPE, infectious virus titers, viral protein expression, and RNA synthesis can be chosen as parameters to evaluate the anti-HRV activity of compounds in cell-culture based assays. Due to the lack of a small-animal model for HRV infection until 2008, the experimental human challenge model has to be used to approve effects of potential antiviral drugs under controlled conditions in preclinical studies.	./cache/cord-270892-ycc3csyh.txt	./txt/cord-270892-ycc3csyh.txt