id sid tid token lemma pos cord-355239-fc52dn3v 1 1 key key NN cord-355239-fc52dn3v 1 2 : : : cord-355239-fc52dn3v 2 1 cord-355239-fc52dn3v cord-355239-fc52dn3v JJ cord-355239-fc52dn3v 2 2 authors author NNS cord-355239-fc52dn3v 2 3 : : : cord-355239-fc52dn3v 2 4 Kato Kato NNP cord-355239-fc52dn3v 2 5 , , , cord-355239-fc52dn3v 2 6 Kentaro Kentaro NNP cord-355239-fc52dn3v 2 7 ; ; : cord-355239-fc52dn3v 2 8 Ishiwa Ishiwa NNP cord-355239-fc52dn3v 2 9 , , , cord-355239-fc52dn3v 3 1 Akiko Akiko NNP cord-355239-fc52dn3v 3 2 title title NN cord-355239-fc52dn3v 3 3 : : : cord-355239-fc52dn3v 3 4 The the DT cord-355239-fc52dn3v 3 5 Role role NN cord-355239-fc52dn3v 3 6 of of IN cord-355239-fc52dn3v 3 7 Carbohydrates carbohydrate NNS cord-355239-fc52dn3v 3 8 in in IN cord-355239-fc52dn3v 3 9 Infection Infection NNP cord-355239-fc52dn3v 3 10 Strategies Strategies NNPS cord-355239-fc52dn3v 3 11 of of IN cord-355239-fc52dn3v 3 12 Enteric enteric JJ cord-355239-fc52dn3v 3 13 Pathogens Pathogens NNPS cord-355239-fc52dn3v 3 14 date date NN cord-355239-fc52dn3v 3 15 : : : cord-355239-fc52dn3v 3 16 2014 2014 CD cord-355239-fc52dn3v 3 17 - - HYPH cord-355239-fc52dn3v 3 18 11 11 CD cord-355239-fc52dn3v 3 19 - - SYM cord-355239-fc52dn3v 3 20 15 15 CD cord-355239-fc52dn3v 3 21 journal journal NN cord-355239-fc52dn3v 3 22 : : : cord-355239-fc52dn3v 3 23 Trop Trop NNP cord-355239-fc52dn3v 3 24 Med Med NNP cord-355239-fc52dn3v 3 25 Health Health NNP cord-355239-fc52dn3v 3 26 DOI doi NN cord-355239-fc52dn3v 3 27 : : : cord-355239-fc52dn3v 4 1 10.2149 10.2149 CD cord-355239-fc52dn3v 4 2 / / SYM cord-355239-fc52dn3v 4 3 tmh.2014 tmh.2014 CD cord-355239-fc52dn3v 4 4 - - SYM cord-355239-fc52dn3v 4 5 25 25 CD cord-355239-fc52dn3v 4 6 sha sha NNP cord-355239-fc52dn3v 4 7 : : : cord-355239-fc52dn3v 5 1 bbe2e49fac5f007f3313b35f9b264bb4219aa67d bbe2e49fac5f007f3313b35f9b264bb4219aa67d NNS cord-355239-fc52dn3v 5 2 doc_id doc_id CD cord-355239-fc52dn3v 5 3 : : : cord-355239-fc52dn3v 5 4 355239 355239 CD cord-355239-fc52dn3v 5 5 cord_uid cord_uid NNS cord-355239-fc52dn3v 5 6 : : : cord-355239-fc52dn3v 5 7 fc52dn3v fc52dn3v JJ cord-355239-fc52dn3v 6 1 Enteric enteric JJ cord-355239-fc52dn3v 6 2 pathogens pathogen NNS cord-355239-fc52dn3v 6 3 cause cause VBP cord-355239-fc52dn3v 6 4 considerable considerable JJ cord-355239-fc52dn3v 6 5 public public JJ cord-355239-fc52dn3v 6 6 health health NN cord-355239-fc52dn3v 6 7 concerns concern NNS cord-355239-fc52dn3v 6 8 worldwide worldwide RB cord-355239-fc52dn3v 6 9 including include VBG cord-355239-fc52dn3v 6 10 tropical tropical JJ cord-355239-fc52dn3v 6 11 regions region NNS cord-355239-fc52dn3v 6 12 . . . cord-355239-fc52dn3v 7 1 Here here RB cord-355239-fc52dn3v 7 2 , , , cord-355239-fc52dn3v 7 3 we -PRON- PRP cord-355239-fc52dn3v 7 4 review review VBP cord-355239-fc52dn3v 7 5 the the DT cord-355239-fc52dn3v 7 6 roles role NNS cord-355239-fc52dn3v 7 7 of of IN cord-355239-fc52dn3v 7 8 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 7 9 in in IN cord-355239-fc52dn3v 7 10 the the DT cord-355239-fc52dn3v 7 11 infection infection NN cord-355239-fc52dn3v 7 12 strategies strategy NNS cord-355239-fc52dn3v 7 13 of of IN cord-355239-fc52dn3v 7 14 various various JJ cord-355239-fc52dn3v 7 15 enteric enteric JJ cord-355239-fc52dn3v 7 16 pathogens pathogen NNS cord-355239-fc52dn3v 7 17 including include VBG cord-355239-fc52dn3v 7 18 viruses virus NNS cord-355239-fc52dn3v 7 19 , , , cord-355239-fc52dn3v 7 20 bacteria bacteria NNS cord-355239-fc52dn3v 7 21 and and CC cord-355239-fc52dn3v 7 22 protozoa protozoan NNS cord-355239-fc52dn3v 7 23 , , , cord-355239-fc52dn3v 7 24 which which WDT cord-355239-fc52dn3v 7 25 infect infect VBP cord-355239-fc52dn3v 7 26 the the DT cord-355239-fc52dn3v 7 27 epithelial epithelial JJ cord-355239-fc52dn3v 7 28 lining lining NN cord-355239-fc52dn3v 7 29 of of IN cord-355239-fc52dn3v 7 30 the the DT cord-355239-fc52dn3v 7 31 human human JJ cord-355239-fc52dn3v 7 32 and and CC cord-355239-fc52dn3v 7 33 animal animal NN cord-355239-fc52dn3v 7 34 intestine intestine NN cord-355239-fc52dn3v 7 35 . . . cord-355239-fc52dn3v 8 1 At at IN cord-355239-fc52dn3v 8 2 host host NN cord-355239-fc52dn3v 8 3 cell cell NN cord-355239-fc52dn3v 8 4 entry entry NN cord-355239-fc52dn3v 8 5 , , , cord-355239-fc52dn3v 8 6 enteric enteric JJ cord-355239-fc52dn3v 8 7 viruses virus NNS cord-355239-fc52dn3v 8 8 , , , cord-355239-fc52dn3v 8 9 including include VBG cord-355239-fc52dn3v 8 10 norovirus norovirus NN cord-355239-fc52dn3v 8 11 , , , cord-355239-fc52dn3v 8 12 recognize recognize VBP cord-355239-fc52dn3v 8 13 mainly mainly RB cord-355239-fc52dn3v 8 14 histo histo JJ cord-355239-fc52dn3v 8 15 - - HYPH cord-355239-fc52dn3v 8 16 blood blood NN cord-355239-fc52dn3v 8 17 group group NN cord-355239-fc52dn3v 8 18 antigens antigen NNS cord-355239-fc52dn3v 8 19 . . . cord-355239-fc52dn3v 9 1 At at IN cord-355239-fc52dn3v 9 2 the the DT cord-355239-fc52dn3v 9 3 initial initial JJ cord-355239-fc52dn3v 9 4 step step NN cord-355239-fc52dn3v 9 5 of of IN cord-355239-fc52dn3v 9 6 bacterial bacterial JJ cord-355239-fc52dn3v 9 7 infections infection NNS cord-355239-fc52dn3v 9 8 , , , cord-355239-fc52dn3v 9 9 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 9 10 also also RB cord-355239-fc52dn3v 9 11 function function VBP cord-355239-fc52dn3v 9 12 as as IN cord-355239-fc52dn3v 9 13 receptors receptor NNS cord-355239-fc52dn3v 9 14 for for IN cord-355239-fc52dn3v 9 15 attachment attachment NN cord-355239-fc52dn3v 9 16 . . . cord-355239-fc52dn3v 10 1 Here here RB cord-355239-fc52dn3v 10 2 , , , cord-355239-fc52dn3v 10 3 we -PRON- PRP cord-355239-fc52dn3v 10 4 describe describe VBP cord-355239-fc52dn3v 10 5 the the DT cord-355239-fc52dn3v 10 6 function function NN cord-355239-fc52dn3v 10 7 of of IN cord-355239-fc52dn3v 10 8 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 10 9 in in IN cord-355239-fc52dn3v 10 10 infection infection NN cord-355239-fc52dn3v 10 11 by by IN cord-355239-fc52dn3v 10 12 Salmonella Salmonella NNP cord-355239-fc52dn3v 10 13 enterica enterica NN cord-355239-fc52dn3v 10 14 and and CC cord-355239-fc52dn3v 10 15 several several JJ cord-355239-fc52dn3v 10 16 bacterial bacterial JJ cord-355239-fc52dn3v 10 17 species specie NNS cord-355239-fc52dn3v 10 18 that that WDT cord-355239-fc52dn3v 10 19 produce produce VBP cord-355239-fc52dn3v 10 20 a a DT cord-355239-fc52dn3v 10 21 variety variety NN cord-355239-fc52dn3v 10 22 of of IN cord-355239-fc52dn3v 10 23 fimbrial fimbrial JJ cord-355239-fc52dn3v 10 24 adhesions adhesion NNS cord-355239-fc52dn3v 10 25 . . . cord-355239-fc52dn3v 11 1 During during IN cord-355239-fc52dn3v 11 2 invasion invasion NN cord-355239-fc52dn3v 11 3 by by IN cord-355239-fc52dn3v 11 4 enteropathogenic enteropathogenic NNP cord-355239-fc52dn3v 11 5 protozoa protozoa NNPS cord-355239-fc52dn3v 11 6 , , , cord-355239-fc52dn3v 11 7 apicomplexan apicomplexan NNP cord-355239-fc52dn3v 11 8 parasites parasite NNS cord-355239-fc52dn3v 11 9 utilize utilize VBP cord-355239-fc52dn3v 11 10 sialic sialic JJ cord-355239-fc52dn3v 11 11 acids acid NNS cord-355239-fc52dn3v 11 12 or or CC cord-355239-fc52dn3v 11 13 sulfated sulfated JJ cord-355239-fc52dn3v 11 14 glycans glycan NNS cord-355239-fc52dn3v 11 15 . . . cord-355239-fc52dn3v 12 1 Carbohydrates carbohydrate NNS cord-355239-fc52dn3v 12 2 serve serve VBP cord-355239-fc52dn3v 12 3 as as IN cord-355239-fc52dn3v 12 4 receptors receptor NNS cord-355239-fc52dn3v 12 5 for for IN cord-355239-fc52dn3v 12 6 infection infection NN cord-355239-fc52dn3v 12 7 by by IN cord-355239-fc52dn3v 12 8 these these DT cord-355239-fc52dn3v 12 9 microbes microbe NNS cord-355239-fc52dn3v 12 10 ; ; : cord-355239-fc52dn3v 12 11 however however RB cord-355239-fc52dn3v 12 12 , , , cord-355239-fc52dn3v 12 13 their -PRON- PRP$ cord-355239-fc52dn3v 12 14 usage usage NN cord-355239-fc52dn3v 12 15 of of IN cord-355239-fc52dn3v 12 16 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 12 17 varies vary VBZ cord-355239-fc52dn3v 12 18 depending depend VBG cord-355239-fc52dn3v 12 19 on on IN cord-355239-fc52dn3v 12 20 the the DT cord-355239-fc52dn3v 12 21 microbe microbe NN cord-355239-fc52dn3v 12 22 . . . cord-355239-fc52dn3v 13 1 On on IN cord-355239-fc52dn3v 13 2 the the DT cord-355239-fc52dn3v 13 3 surface surface NN cord-355239-fc52dn3v 13 4 of of IN cord-355239-fc52dn3v 13 5 the the DT cord-355239-fc52dn3v 13 6 mucosal mucosal JJ cord-355239-fc52dn3v 13 7 tissues tissue NNS cord-355239-fc52dn3v 13 8 of of IN cord-355239-fc52dn3v 13 9 the the DT cord-355239-fc52dn3v 13 10 gastrointestinal gastrointestinal JJ cord-355239-fc52dn3v 13 11 tract tract NN cord-355239-fc52dn3v 13 12 , , , cord-355239-fc52dn3v 13 13 various various JJ cord-355239-fc52dn3v 13 14 carbohydrate carbohydrate NN cord-355239-fc52dn3v 13 15 moieties moiety NNS cord-355239-fc52dn3v 13 16 are be VBP cord-355239-fc52dn3v 13 17 present present JJ cord-355239-fc52dn3v 13 18 and and CC cord-355239-fc52dn3v 13 19 play play VB cord-355239-fc52dn3v 13 20 a a DT cord-355239-fc52dn3v 13 21 crucial crucial JJ cord-355239-fc52dn3v 13 22 role role NN cord-355239-fc52dn3v 13 23 in in IN cord-355239-fc52dn3v 13 24 infection infection NN cord-355239-fc52dn3v 13 25 , , , cord-355239-fc52dn3v 13 26 representing represent VBG cord-355239-fc52dn3v 13 27 the the DT cord-355239-fc52dn3v 13 28 site site NN cord-355239-fc52dn3v 13 29 of of IN cord-355239-fc52dn3v 13 30 infection infection NN cord-355239-fc52dn3v 13 31 or or CC cord-355239-fc52dn3v 13 32 route route NN cord-355239-fc52dn3v 13 33 of of IN cord-355239-fc52dn3v 13 34 access access NN cord-355239-fc52dn3v 13 35 for for IN cord-355239-fc52dn3v 13 36 most most JJS cord-355239-fc52dn3v 13 37 microbes microbe NNS cord-355239-fc52dn3v 13 38 . . . cord-355239-fc52dn3v 14 1 During during IN cord-355239-fc52dn3v 14 2 the the DT cord-355239-fc52dn3v 14 3 infection infection NN cord-355239-fc52dn3v 14 4 and/or and/or CC cord-355239-fc52dn3v 14 5 invasion invasion NN cord-355239-fc52dn3v 14 6 process process NN cord-355239-fc52dn3v 14 7 of of IN cord-355239-fc52dn3v 14 8 the the DT cord-355239-fc52dn3v 14 9 microbes microbe NNS cord-355239-fc52dn3v 14 10 , , , cord-355239-fc52dn3v 14 11 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 14 12 function function VBP cord-355239-fc52dn3v 14 13 as as IN cord-355239-fc52dn3v 14 14 receptors receptor NNS cord-355239-fc52dn3v 14 15 for for IN cord-355239-fc52dn3v 14 16 various various JJ cord-355239-fc52dn3v 14 17 microbes microbe NNS cord-355239-fc52dn3v 14 18 , , , cord-355239-fc52dn3v 14 19 but but CC cord-355239-fc52dn3v 14 20 they -PRON- PRP cord-355239-fc52dn3v 14 21 can can MD cord-355239-fc52dn3v 14 22 also also RB cord-355239-fc52dn3v 14 23 function function VB cord-355239-fc52dn3v 14 24 as as IN cord-355239-fc52dn3v 14 25 a a DT cord-355239-fc52dn3v 14 26 barrier barrier NN cord-355239-fc52dn3v 14 27 to to IN cord-355239-fc52dn3v 14 28 infection infection NN cord-355239-fc52dn3v 14 29 . . . cord-355239-fc52dn3v 15 1 One one CD cord-355239-fc52dn3v 15 2 approach approach NN cord-355239-fc52dn3v 15 3 to to TO cord-355239-fc52dn3v 15 4 develop develop VB cord-355239-fc52dn3v 15 5 effective effective JJ cord-355239-fc52dn3v 15 6 prophylactic prophylactic JJ cord-355239-fc52dn3v 15 7 and and CC cord-355239-fc52dn3v 15 8 therapeutic therapeutic JJ cord-355239-fc52dn3v 15 9 antimicrobial antimicrobial JJ cord-355239-fc52dn3v 15 10 agents agent NNS cord-355239-fc52dn3v 15 11 is be VBZ cord-355239-fc52dn3v 15 12 to to TO cord-355239-fc52dn3v 15 13 modify modify VB cord-355239-fc52dn3v 15 14 the the DT cord-355239-fc52dn3v 15 15 drug drug NN cord-355239-fc52dn3v 15 16 structure structure NN cord-355239-fc52dn3v 15 17 . . . cord-355239-fc52dn3v 16 1 Another another DT cord-355239-fc52dn3v 16 2 approach approach NN cord-355239-fc52dn3v 16 3 is be VBZ cord-355239-fc52dn3v 16 4 to to TO cord-355239-fc52dn3v 16 5 modify modify VB cord-355239-fc52dn3v 16 6 the the DT cord-355239-fc52dn3v 16 7 mode mode NN cord-355239-fc52dn3v 16 8 of of IN cord-355239-fc52dn3v 16 9 inhibition inhibition NN cord-355239-fc52dn3v 16 10 of of IN cord-355239-fc52dn3v 16 11 infection infection NN cord-355239-fc52dn3v 16 12 depending depend VBG cord-355239-fc52dn3v 16 13 on on IN cord-355239-fc52dn3v 16 14 the the DT cord-355239-fc52dn3v 16 15 individual individual JJ cord-355239-fc52dn3v 16 16 pathogen pathogen NN cord-355239-fc52dn3v 16 17 by by IN cord-355239-fc52dn3v 16 18 using use VBG cord-355239-fc52dn3v 16 19 and and CC cord-355239-fc52dn3v 16 20 mimicking mimic VBG cord-355239-fc52dn3v 16 21 the the DT cord-355239-fc52dn3v 16 22 interactions interaction NNS cord-355239-fc52dn3v 16 23 with with IN cord-355239-fc52dn3v 16 24 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 16 25 . . . cord-355239-fc52dn3v 17 1 In in IN cord-355239-fc52dn3v 17 2 addition addition NN cord-355239-fc52dn3v 17 3 , , , cord-355239-fc52dn3v 17 4 similarities similarity NNS cord-355239-fc52dn3v 17 5 in in IN cord-355239-fc52dn3v 17 6 mode mode NN cord-355239-fc52dn3v 17 7 of of IN cord-355239-fc52dn3v 17 8 infection infection NN cord-355239-fc52dn3v 17 9 may may MD cord-355239-fc52dn3v 17 10 also also RB cord-355239-fc52dn3v 17 11 be be VB cord-355239-fc52dn3v 17 12 utilized utilize VBN cord-355239-fc52dn3v 17 13 . . . cord-355239-fc52dn3v 18 1 Our -PRON- PRP$ cord-355239-fc52dn3v 18 2 findings finding NNS cord-355239-fc52dn3v 18 3 will will MD cord-355239-fc52dn3v 18 4 be be VB cord-355239-fc52dn3v 18 5 useful useful JJ cord-355239-fc52dn3v 18 6 in in IN cord-355239-fc52dn3v 18 7 the the DT cord-355239-fc52dn3v 18 8 development development NN cord-355239-fc52dn3v 18 9 of of IN cord-355239-fc52dn3v 18 10 new new JJ cord-355239-fc52dn3v 18 11 drugs drug NNS cord-355239-fc52dn3v 18 12 for for IN cord-355239-fc52dn3v 18 13 the the DT cord-355239-fc52dn3v 18 14 treatment treatment NN cord-355239-fc52dn3v 18 15 of of IN cord-355239-fc52dn3v 18 16 enteric enteric JJ cord-355239-fc52dn3v 18 17 pathogens pathogen NNS cord-355239-fc52dn3v 18 18 . . . cord-355239-fc52dn3v 19 1 Enteric enteric JJ cord-355239-fc52dn3v 19 2 pathogens pathogen NNS cord-355239-fc52dn3v 19 3 , , , cord-355239-fc52dn3v 19 4 many many JJ cord-355239-fc52dn3v 19 5 of of IN cord-355239-fc52dn3v 19 6 which which WDT cord-355239-fc52dn3v 19 7 are be VBP cord-355239-fc52dn3v 19 8 zoonotic zoonotic JJ cord-355239-fc52dn3v 19 9 , , , cord-355239-fc52dn3v 19 10 exert exert VB cord-355239-fc52dn3v 19 11 a a DT cord-355239-fc52dn3v 19 12 major major JJ cord-355239-fc52dn3v 19 13 impact impact NN cord-355239-fc52dn3v 19 14 on on IN cord-355239-fc52dn3v 19 15 public public JJ cord-355239-fc52dn3v 19 16 health health NN cord-355239-fc52dn3v 19 17 worldwide worldwide RB cord-355239-fc52dn3v 19 18 including include VBG cord-355239-fc52dn3v 19 19 tropical tropical JJ cord-355239-fc52dn3v 19 20 regions region NNS cord-355239-fc52dn3v 19 21 . . . cord-355239-fc52dn3v 20 1 In in IN cord-355239-fc52dn3v 20 2 humans human NNS cord-355239-fc52dn3v 20 3 and and CC cord-355239-fc52dn3v 20 4 animals animal NNS cord-355239-fc52dn3v 20 5 , , , cord-355239-fc52dn3v 20 6 the the DT cord-355239-fc52dn3v 20 7 enteric enteric JJ cord-355239-fc52dn3v 20 8 pathogens pathogen NNS cord-355239-fc52dn3v 20 9 , , , cord-355239-fc52dn3v 20 10 which which WDT cord-355239-fc52dn3v 20 11 include include VBP cord-355239-fc52dn3v 20 12 viruses virus NNS cord-355239-fc52dn3v 20 13 , , , cord-355239-fc52dn3v 20 14 bacteria bacteria NNS cord-355239-fc52dn3v 20 15 and and CC cord-355239-fc52dn3v 20 16 protozoa protozoan NNS cord-355239-fc52dn3v 20 17 , , , cord-355239-fc52dn3v 20 18 infect infect VB cord-355239-fc52dn3v 20 19 the the DT cord-355239-fc52dn3v 20 20 intestine intestine NN cord-355239-fc52dn3v 20 21 epithelial epithelial JJ cord-355239-fc52dn3v 20 22 lining lining NN cord-355239-fc52dn3v 20 23 , , , cord-355239-fc52dn3v 20 24 resulting result VBG cord-355239-fc52dn3v 20 25 in in IN cord-355239-fc52dn3v 20 26 food food NN cord-355239-fc52dn3v 20 27 poisoning poisoning NN cord-355239-fc52dn3v 20 28 or or CC cord-355239-fc52dn3v 20 29 diarrheal diarrheal JJ cord-355239-fc52dn3v 20 30 disease disease NN cord-355239-fc52dn3v 20 31 . . . cord-355239-fc52dn3v 21 1 When when WRB cord-355239-fc52dn3v 21 2 enteric enteric JJ cord-355239-fc52dn3v 21 3 pathogens pathogen NNS cord-355239-fc52dn3v 21 4 enter enter VBP cord-355239-fc52dn3v 21 5 humans human NNS cord-355239-fc52dn3v 21 6 or or CC cord-355239-fc52dn3v 21 7 animals animal NNS cord-355239-fc52dn3v 21 8 via via IN cord-355239-fc52dn3v 21 9 the the DT cord-355239-fc52dn3v 21 10 oral oral JJ cord-355239-fc52dn3v 21 11 route route NN cord-355239-fc52dn3v 21 12 , , , cord-355239-fc52dn3v 21 13 they -PRON- PRP cord-355239-fc52dn3v 21 14 must must MD cord-355239-fc52dn3v 21 15 withstand withstand VB cord-355239-fc52dn3v 21 16 the the DT cord-355239-fc52dn3v 21 17 proteolytic proteolytic JJ cord-355239-fc52dn3v 21 18 conditions condition NNS cord-355239-fc52dn3v 21 19 in in IN cord-355239-fc52dn3v 21 20 the the DT cord-355239-fc52dn3v 21 21 stomach stomach NN cord-355239-fc52dn3v 21 22 before before IN cord-355239-fc52dn3v 21 23 penetrating penetrate VBG cord-355239-fc52dn3v 21 24 the the DT cord-355239-fc52dn3v 21 25 mucus mucus NN cord-355239-fc52dn3v 21 26 layer layer NN cord-355239-fc52dn3v 21 27 and and CC cord-355239-fc52dn3v 21 28 accessing access VBG cord-355239-fc52dn3v 21 29 the the DT cord-355239-fc52dn3v 21 30 underlying underlie VBG cord-355239-fc52dn3v 21 31 gut gut NN cord-355239-fc52dn3v 21 32 epithelium epithelium NN cord-355239-fc52dn3v 21 33 for for IN cord-355239-fc52dn3v 21 34 attachment attachment NN cord-355239-fc52dn3v 21 35 or or CC cord-355239-fc52dn3v 21 36 cell cell NN cord-355239-fc52dn3v 21 37 invasion invasion NN cord-355239-fc52dn3v 21 38 . . . cord-355239-fc52dn3v 22 1 Adhesion adhesion NN cord-355239-fc52dn3v 22 2 of of IN cord-355239-fc52dn3v 22 3 the the DT cord-355239-fc52dn3v 22 4 enteric enteric JJ cord-355239-fc52dn3v 22 5 pathogens pathogen NNS cord-355239-fc52dn3v 22 6 to to IN cord-355239-fc52dn3v 22 7 the the DT cord-355239-fc52dn3v 22 8 intestine intestine NN cord-355239-fc52dn3v 22 9 epithelial epithelial JJ cord-355239-fc52dn3v 22 10 tissue tissue NN cord-355239-fc52dn3v 22 11 is be VBZ cord-355239-fc52dn3v 22 12 a a DT cord-355239-fc52dn3v 22 13 prerequisite prerequisite NN cord-355239-fc52dn3v 22 14 for for IN cord-355239-fc52dn3v 22 15 the the DT cord-355239-fc52dn3v 22 16 initiation initiation NN cord-355239-fc52dn3v 22 17 of of IN cord-355239-fc52dn3v 22 18 infection infection NN cord-355239-fc52dn3v 22 19 . . . cord-355239-fc52dn3v 23 1 In in IN cord-355239-fc52dn3v 23 2 many many JJ cord-355239-fc52dn3v 23 3 systems system NNS cord-355239-fc52dn3v 23 4 it -PRON- PRP cord-355239-fc52dn3v 23 5 is be VBZ cord-355239-fc52dn3v 23 6 mediated mediate VBN cord-355239-fc52dn3v 23 7 by by IN cord-355239-fc52dn3v 23 8 lectins lectin NNS cord-355239-fc52dn3v 23 9 present present JJ cord-355239-fc52dn3v 23 10 on on IN cord-355239-fc52dn3v 23 11 the the DT cord-355239-fc52dn3v 23 12 surface surface NN cord-355239-fc52dn3v 23 13 of of IN cord-355239-fc52dn3v 23 14 the the DT cord-355239-fc52dn3v 23 15 pathogen pathogen NN cord-355239-fc52dn3v 23 16 that that WDT cord-355239-fc52dn3v 23 17 bind bind VBP cord-355239-fc52dn3v 23 18 to to IN cord-355239-fc52dn3v 23 19 complementary complementary JJ cord-355239-fc52dn3v 23 20 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 23 21 on on IN cord-355239-fc52dn3v 23 22 the the DT cord-355239-fc52dn3v 23 23 surface surface NN cord-355239-fc52dn3v 23 24 of of IN cord-355239-fc52dn3v 23 25 the the DT cord-355239-fc52dn3v 23 26 host host NN cord-355239-fc52dn3v 23 27 cells cell NNS cord-355239-fc52dn3v 23 28 . . . cord-355239-fc52dn3v 24 1 Carbohydrates carbohydrate NNS cord-355239-fc52dn3v 24 2 such such JJ cord-355239-fc52dn3v 24 3 as as IN cord-355239-fc52dn3v 24 4 heparan heparan JJ cord-355239-fc52dn3v 24 5 sulfate sulfate NN cord-355239-fc52dn3v 24 6 have have VBP cord-355239-fc52dn3v 24 7 been be VBN cord-355239-fc52dn3v 24 8 reported report VBN cord-355239-fc52dn3v 24 9 to to TO cord-355239-fc52dn3v 24 10 play play VB cord-355239-fc52dn3v 24 11 a a DT cord-355239-fc52dn3v 24 12 crucial crucial JJ cord-355239-fc52dn3v 24 13 role role NN cord-355239-fc52dn3v 24 14 in in IN cord-355239-fc52dn3v 24 15 the the DT cord-355239-fc52dn3v 24 16 entry entry NN cord-355239-fc52dn3v 24 17 or or CC cord-355239-fc52dn3v 24 18 budding budding NN cord-355239-fc52dn3v 24 19 of of IN cord-355239-fc52dn3v 24 20 viruses virus NNS cord-355239-fc52dn3v 24 21 [ [ -LRB- cord-355239-fc52dn3v 24 22 1 1 CD cord-355239-fc52dn3v 24 23 ] ] -RRB- cord-355239-fc52dn3v 24 24 , , , cord-355239-fc52dn3v 24 25 and and CC cord-355239-fc52dn3v 24 26 bacterial bacterial JJ cord-355239-fc52dn3v 24 27 lectins lectin NNS cord-355239-fc52dn3v 24 28 typically typically RB cord-355239-fc52dn3v 24 29 act act VBP cord-355239-fc52dn3v 24 30 in in IN cord-355239-fc52dn3v 24 31 the the DT cord-355239-fc52dn3v 24 32 form form NN cord-355239-fc52dn3v 24 33 of of IN cord-355239-fc52dn3v 24 34 elongated elongated JJ cord-355239-fc52dn3v 24 35 submicroscopic submicroscopic JJ cord-355239-fc52dn3v 24 36 multisubunit multisubunit NN cord-355239-fc52dn3v 24 37 protein protein NN cord-355239-fc52dn3v 24 38 appendages appendage NNS cord-355239-fc52dn3v 24 39 , , , cord-355239-fc52dn3v 24 40 known know VBN cord-355239-fc52dn3v 24 41 as as IN cord-355239-fc52dn3v 24 42 pili pili NNP cord-355239-fc52dn3v 24 43 [ [ -LRB- cord-355239-fc52dn3v 24 44 2 2 CD cord-355239-fc52dn3v 24 45 ] ] -RRB- cord-355239-fc52dn3v 24 46 . . . cord-355239-fc52dn3v 25 1 Recently recently RB cord-355239-fc52dn3v 25 2 , , , cord-355239-fc52dn3v 25 3 the the DT cord-355239-fc52dn3v 25 4 surface surface NN cord-355239-fc52dn3v 25 5 proteins protein NNS cord-355239-fc52dn3v 25 6 of of IN cord-355239-fc52dn3v 25 7 apicomplexan apicomplexan NNP cord-355239-fc52dn3v 25 8 parasites parasite NNS cord-355239-fc52dn3v 25 9 have have VBP cord-355239-fc52dn3v 25 10 also also RB cord-355239-fc52dn3v 25 11 been be VBN cord-355239-fc52dn3v 25 12 reported report VBN cord-355239-fc52dn3v 25 13 to to TO cord-355239-fc52dn3v 25 14 bind bind VB cord-355239-fc52dn3v 25 15 to to IN cord-355239-fc52dn3v 25 16 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 25 17 on on IN cord-355239-fc52dn3v 25 18 host host NN cord-355239-fc52dn3v 25 19 cells cell NNS cord-355239-fc52dn3v 25 20 [ [ -LRB- cord-355239-fc52dn3v 25 21 3 3 CD cord-355239-fc52dn3v 25 22 ] ] -RRB- cord-355239-fc52dn3v 25 23 . . . cord-355239-fc52dn3v 26 1 Thus thus RB cord-355239-fc52dn3v 26 2 the the DT cord-355239-fc52dn3v 26 3 initial initial JJ cord-355239-fc52dn3v 26 4 steps step NNS cord-355239-fc52dn3v 26 5 of of IN cord-355239-fc52dn3v 26 6 host host NN cord-355239-fc52dn3v 26 7 cell cell NN cord-355239-fc52dn3v 26 8 recognition recognition NN cord-355239-fc52dn3v 26 9 by by IN cord-355239-fc52dn3v 26 10 enteric enteric JJ cord-355239-fc52dn3v 26 11 pathogens pathogen NNS cord-355239-fc52dn3v 26 12 may may MD cord-355239-fc52dn3v 26 13 incorporate incorporate VB cord-355239-fc52dn3v 26 14 common common JJ cord-355239-fc52dn3v 26 15 strategies strategy NNS cord-355239-fc52dn3v 26 16 . . . cord-355239-fc52dn3v 27 1 Once once IN cord-355239-fc52dn3v 27 2 pathogens pathogen NNS cord-355239-fc52dn3v 27 3 invade invade VBP cord-355239-fc52dn3v 27 4 the the DT cord-355239-fc52dn3v 27 5 host host NN cord-355239-fc52dn3v 27 6 cells cell NNS cord-355239-fc52dn3v 27 7 , , , cord-355239-fc52dn3v 27 8 they -PRON- PRP cord-355239-fc52dn3v 27 9 initiate initiate VBP cord-355239-fc52dn3v 27 10 their -PRON- PRP$ cord-355239-fc52dn3v 27 11 survival survival NN cord-355239-fc52dn3v 27 12 mechanisms mechanism NNS cord-355239-fc52dn3v 27 13 to to TO cord-355239-fc52dn3v 27 14 avoid avoid VB cord-355239-fc52dn3v 27 15 extermination extermination NN cord-355239-fc52dn3v 27 16 by by IN cord-355239-fc52dn3v 27 17 host host NN cord-355239-fc52dn3v 27 18 immunity immunity NN cord-355239-fc52dn3v 27 19 . . . cord-355239-fc52dn3v 28 1 Ultimately ultimately RB cord-355239-fc52dn3v 28 2 , , , cord-355239-fc52dn3v 28 3 if if IN cord-355239-fc52dn3v 28 4 infection infection NN cord-355239-fc52dn3v 28 5 of of IN cord-355239-fc52dn3v 28 6 host host NN cord-355239-fc52dn3v 28 7 cells cell NNS cord-355239-fc52dn3v 28 8 could could MD cord-355239-fc52dn3v 28 9 be be VB cord-355239-fc52dn3v 28 10 inhibited inhibit VBN cord-355239-fc52dn3v 28 11 , , , cord-355239-fc52dn3v 28 12 proliferation proliferation NN cord-355239-fc52dn3v 28 13 of of IN cord-355239-fc52dn3v 28 14 the the DT cord-355239-fc52dn3v 28 15 pathogens pathogen NNS cord-355239-fc52dn3v 28 16 could could MD cord-355239-fc52dn3v 28 17 be be VB cord-355239-fc52dn3v 28 18 prevented prevent VBN cord-355239-fc52dn3v 28 19 and and CC cord-355239-fc52dn3v 28 20 pathogenesis pathogenesis NN cord-355239-fc52dn3v 28 21 could could MD cord-355239-fc52dn3v 28 22 be be VB cord-355239-fc52dn3v 28 23 controlled control VBN cord-355239-fc52dn3v 28 24 . . . cord-355239-fc52dn3v 29 1 Insights insight NNS cord-355239-fc52dn3v 29 2 obtained obtain VBN cord-355239-fc52dn3v 29 3 from from IN cord-355239-fc52dn3v 29 4 studies study NNS cord-355239-fc52dn3v 29 5 designed design VBN cord-355239-fc52dn3v 29 6 to to TO cord-355239-fc52dn3v 29 7 address address VB cord-355239-fc52dn3v 29 8 this this DT cord-355239-fc52dn3v 29 9 concept concept NN cord-355239-fc52dn3v 29 10 will will MD cord-355239-fc52dn3v 29 11 be be VB cord-355239-fc52dn3v 29 12 invaluable invaluable JJ cord-355239-fc52dn3v 29 13 to to TO cord-355239-fc52dn3v 29 14 develop develop VB cord-355239-fc52dn3v 29 15 novel novel JJ cord-355239-fc52dn3v 29 16 therapies therapy NNS cord-355239-fc52dn3v 29 17 using use VBG cord-355239-fc52dn3v 29 18 innovative innovative JJ cord-355239-fc52dn3v 29 19 drug drug NN cord-355239-fc52dn3v 29 20 design design NN cord-355239-fc52dn3v 29 21 and and CC cord-355239-fc52dn3v 29 22 engineered engineer VBN cord-355239-fc52dn3v 29 23 vaccine vaccine NN cord-355239-fc52dn3v 29 24 candidates candidate NNS cord-355239-fc52dn3v 29 25 to to TO cord-355239-fc52dn3v 29 26 limit limit VB cord-355239-fc52dn3v 29 27 the the DT cord-355239-fc52dn3v 29 28 infectivity infectivity NN cord-355239-fc52dn3v 29 29 of of IN cord-355239-fc52dn3v 29 30 widespread widespread JJ cord-355239-fc52dn3v 29 31 enteric enteric JJ cord-355239-fc52dn3v 29 32 pathogens pathogen NNS cord-355239-fc52dn3v 29 33 . . . cord-355239-fc52dn3v 30 1 Here here RB cord-355239-fc52dn3v 30 2 , , , cord-355239-fc52dn3v 30 3 we -PRON- PRP cord-355239-fc52dn3v 30 4 review review VBP cord-355239-fc52dn3v 30 5 the the DT cord-355239-fc52dn3v 30 6 recent recent JJ cord-355239-fc52dn3v 30 7 major major JJ cord-355239-fc52dn3v 30 8 advances advance NNS cord-355239-fc52dn3v 30 9 in in IN cord-355239-fc52dn3v 30 10 research research NN cord-355239-fc52dn3v 30 11 on on IN cord-355239-fc52dn3v 30 12 the the DT cord-355239-fc52dn3v 30 13 role role NN cord-355239-fc52dn3v 30 14 of of IN cord-355239-fc52dn3v 30 15 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 30 16 in in IN cord-355239-fc52dn3v 30 17 the the DT cord-355239-fc52dn3v 30 18 infection infection NN cord-355239-fc52dn3v 30 19 strategies strategy NNS cord-355239-fc52dn3v 30 20 of of IN cord-355239-fc52dn3v 30 21 enteric enteric JJ cord-355239-fc52dn3v 30 22 pathogenic pathogenic JJ cord-355239-fc52dn3v 30 23 viruses virus NNS cord-355239-fc52dn3v 30 24 , , , cord-355239-fc52dn3v 30 25 bacteria bacteria NNS cord-355239-fc52dn3v 30 26 and and CC cord-355239-fc52dn3v 30 27 protozoa protozoan NNS cord-355239-fc52dn3v 30 28 . . . cord-355239-fc52dn3v 31 1 We -PRON- PRP cord-355239-fc52dn3v 31 2 further further RB cord-355239-fc52dn3v 31 3 discuss discuss VBP cord-355239-fc52dn3v 31 4 how how WRB cord-355239-fc52dn3v 31 5 our -PRON- PRP$ cord-355239-fc52dn3v 31 6 knowledge knowledge NN cord-355239-fc52dn3v 31 7 regarding regard VBG cord-355239-fc52dn3v 31 8 these these DT cord-355239-fc52dn3v 31 9 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 31 10 may may MD cord-355239-fc52dn3v 31 11 influence influence VB cord-355239-fc52dn3v 31 12 prophylactic prophylactic JJ cord-355239-fc52dn3v 31 13 and and CC cord-355239-fc52dn3v 31 14 therapeutic therapeutic JJ cord-355239-fc52dn3v 31 15 drug drug NN cord-355239-fc52dn3v 31 16 development development NN cord-355239-fc52dn3v 31 17 for for IN cord-355239-fc52dn3v 31 18 the the DT cord-355239-fc52dn3v 31 19 treatment treatment NN cord-355239-fc52dn3v 31 20 of of IN cord-355239-fc52dn3v 31 21 diseases disease NNS cord-355239-fc52dn3v 31 22 caused cause VBN cord-355239-fc52dn3v 31 23 by by IN cord-355239-fc52dn3v 31 24 enteric enteric JJ cord-355239-fc52dn3v 31 25 pathogens pathogen NNS cord-355239-fc52dn3v 31 26 . . . cord-355239-fc52dn3v 32 1 Carbohydrates carbohydrate NNS cord-355239-fc52dn3v 32 2 function function VBP cord-355239-fc52dn3v 32 3 as as IN cord-355239-fc52dn3v 32 4 receptors receptor NNS cord-355239-fc52dn3v 32 5 for for IN cord-355239-fc52dn3v 32 6 virus virus NN cord-355239-fc52dn3v 32 7 entry entry NN cord-355239-fc52dn3v 32 8 . . . cord-355239-fc52dn3v 33 1 Negatively negatively RB cord-355239-fc52dn3v 33 2 charged charge VBN cord-355239-fc52dn3v 33 3 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 33 4 , , , cord-355239-fc52dn3v 33 5 which which WDT cord-355239-fc52dn3v 33 6 are be VBP cord-355239-fc52dn3v 33 7 expressed express VBN cord-355239-fc52dn3v 33 8 on on IN cord-355239-fc52dn3v 33 9 many many JJ cord-355239-fc52dn3v 33 10 types type NNS cord-355239-fc52dn3v 33 11 of of IN cord-355239-fc52dn3v 33 12 cells cell NNS cord-355239-fc52dn3v 33 13 and and CC cord-355239-fc52dn3v 33 14 tissues tissue NNS cord-355239-fc52dn3v 33 15 such such JJ cord-355239-fc52dn3v 33 16 as as IN cord-355239-fc52dn3v 33 17 sialic sialic JJ cord-355239-fc52dn3v 33 18 acid acid NN cord-355239-fc52dn3v 33 19 and and CC cord-355239-fc52dn3v 33 20 heparan heparan NN cord-355239-fc52dn3v 33 21 sulfate sulfate NN cord-355239-fc52dn3v 33 22 , , , cord-355239-fc52dn3v 33 23 are be VBP cord-355239-fc52dn3v 33 24 common common JJ cord-355239-fc52dn3v 33 25 viral viral JJ cord-355239-fc52dn3v 33 26 receptors receptor NNS cord-355239-fc52dn3v 33 27 . . . cord-355239-fc52dn3v 34 1 Orthomyxovirus Orthomyxovirus NNP cord-355239-fc52dn3v 34 2 , , , cord-355239-fc52dn3v 34 3 polyomavirus polyomavirus NNP cord-355239-fc52dn3v 34 4 , , , cord-355239-fc52dn3v 34 5 reovirus reovirus NNP cord-355239-fc52dn3v 34 6 , , , cord-355239-fc52dn3v 34 7 coronavirus coronavirus NN cord-355239-fc52dn3v 34 8 , , , cord-355239-fc52dn3v 34 9 paramyxovirus paramyxovirus NN cord-355239-fc52dn3v 34 10 and and CC cord-355239-fc52dn3v 34 11 parvovirus parvovirus NN cord-355239-fc52dn3v 34 12 recognize recognize VBP cord-355239-fc52dn3v 34 13 sialic sialic JJ cord-355239-fc52dn3v 34 14 acid acid NN cord-355239-fc52dn3v 34 15 as as IN cord-355239-fc52dn3v 34 16 a a DT cord-355239-fc52dn3v 34 17 receptor receptor NN cord-355239-fc52dn3v 34 18 . . . cord-355239-fc52dn3v 35 1 Adenoassociated adenoassociate VBN cord-355239-fc52dn3v 35 2 virus virus NN cord-355239-fc52dn3v 35 3 , , , cord-355239-fc52dn3v 35 4 herpesvirus herpesvirus NN cord-355239-fc52dn3v 35 5 and and CC cord-355239-fc52dn3v 35 6 flavivirus flavivirus NNP cord-355239-fc52dn3v 35 7 recognize recognize VB cord-355239-fc52dn3v 35 8 heparan heparan NN cord-355239-fc52dn3v 35 9 sulfate sulfate NN cord-355239-fc52dn3v 35 10 . . . cord-355239-fc52dn3v 36 1 On on IN cord-355239-fc52dn3v 36 2 the the DT cord-355239-fc52dn3v 36 3 other other JJ cord-355239-fc52dn3v 36 4 hand hand NN cord-355239-fc52dn3v 36 5 , , , cord-355239-fc52dn3v 36 6 the the DT cord-355239-fc52dn3v 36 7 enteric enteric JJ cord-355239-fc52dn3v 36 8 virus virus NN cord-355239-fc52dn3v 36 9 norovirus norovirus NN cord-355239-fc52dn3v 36 10 recognizes recognize VBZ cord-355239-fc52dn3v 36 11 histo histo JJ cord-355239-fc52dn3v 36 12 - - HYPH cord-355239-fc52dn3v 36 13 blood blood NN cord-355239-fc52dn3v 36 14 group group NN cord-355239-fc52dn3v 36 15 antigens antigen NNS cord-355239-fc52dn3v 36 16 ( ( -LRB- cord-355239-fc52dn3v 36 17 HBGAs hbga NNS cord-355239-fc52dn3v 36 18 ) ) -RRB- cord-355239-fc52dn3v 36 19 , , , cord-355239-fc52dn3v 36 20 which which WDT cord-355239-fc52dn3v 36 21 are be VBP cord-355239-fc52dn3v 36 22 not not RB cord-355239-fc52dn3v 36 23 charged charge VBN cord-355239-fc52dn3v 36 24 . . . cord-355239-fc52dn3v 37 1 Here here RB cord-355239-fc52dn3v 37 2 , , , cord-355239-fc52dn3v 37 3 we -PRON- PRP cord-355239-fc52dn3v 37 4 focus focus VBP cord-355239-fc52dn3v 37 5 on on IN cord-355239-fc52dn3v 37 6 the the DT cord-355239-fc52dn3v 37 7 association association NN cord-355239-fc52dn3v 37 8 of of IN cord-355239-fc52dn3v 37 9 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 37 10 with with IN cord-355239-fc52dn3v 37 11 norovirus norovirus NN cord-355239-fc52dn3v 37 12 as as IN cord-355239-fc52dn3v 37 13 the the DT cord-355239-fc52dn3v 37 14 virus virus NN cord-355239-fc52dn3v 37 15 enters enter VBZ cord-355239-fc52dn3v 37 16 the the DT cord-355239-fc52dn3v 37 17 host host NN cord-355239-fc52dn3v 37 18 cell cell NN cord-355239-fc52dn3v 37 19 . . . cord-355239-fc52dn3v 38 1 Norovirus Norovirus NNP cord-355239-fc52dn3v 38 2 , , , cord-355239-fc52dn3v 38 3 a a DT cord-355239-fc52dn3v 38 4 member member NN cord-355239-fc52dn3v 38 5 of of IN cord-355239-fc52dn3v 38 6 the the DT cord-355239-fc52dn3v 38 7 family family NN cord-355239-fc52dn3v 38 8 Caliciviridae Caliciviridae NNP cord-355239-fc52dn3v 38 9 , , , cord-355239-fc52dn3v 38 10 is be VBZ cord-355239-fc52dn3v 38 11 a a DT cord-355239-fc52dn3v 38 12 major major JJ cord-355239-fc52dn3v 38 13 cause cause NN cord-355239-fc52dn3v 38 14 of of IN cord-355239-fc52dn3v 38 15 acute acute JJ cord-355239-fc52dn3v 38 16 water water NN cord-355239-fc52dn3v 38 17 - - HYPH cord-355239-fc52dn3v 38 18 and and CC cord-355239-fc52dn3v 38 19 food food NN cord-355239-fc52dn3v 38 20 - - HYPH cord-355239-fc52dn3v 38 21 borne bear VBN cord-355239-fc52dn3v 38 22 gastroenteritis gastroenteritis NN cord-355239-fc52dn3v 38 23 [ [ -LRB- cord-355239-fc52dn3v 38 24 4 4 CD cord-355239-fc52dn3v 38 25 ] ] -RRB- cord-355239-fc52dn3v 38 26 . . . cord-355239-fc52dn3v 39 1 Norovirus norovirus NN cord-355239-fc52dn3v 39 2 infection infection NN cord-355239-fc52dn3v 39 3 is be VBZ cord-355239-fc52dn3v 39 4 associated associate VBN cord-355239-fc52dn3v 39 5 with with IN cord-355239-fc52dn3v 39 6 up up IN cord-355239-fc52dn3v 39 7 to to TO cord-355239-fc52dn3v 39 8 90 90 CD cord-355239-fc52dn3v 39 9 % % NN cord-355239-fc52dn3v 39 10 of of IN cord-355239-fc52dn3v 39 11 epidemic epidemic NN cord-355239-fc52dn3v 39 12 nonbacterial nonbacterial JJ cord-355239-fc52dn3v 39 13 acute acute JJ cord-355239-fc52dn3v 39 14 gastroenteritis gastroenteritis NN cord-355239-fc52dn3v 39 15 cases case NNS cord-355239-fc52dn3v 39 16 worldwide worldwide RB cord-355239-fc52dn3v 39 17 [ [ -LRB- cord-355239-fc52dn3v 39 18 5 5 CD cord-355239-fc52dn3v 39 19 ] ] -RRB- cord-355239-fc52dn3v 39 20 . . . cord-355239-fc52dn3v 40 1 Noroviruses noroviruse NNS cord-355239-fc52dn3v 40 2 are be VBP cord-355239-fc52dn3v 40 3 divided divide VBN cord-355239-fc52dn3v 40 4 into into IN cord-355239-fc52dn3v 40 5 at at RB cord-355239-fc52dn3v 40 6 least least RBS cord-355239-fc52dn3v 40 7 five five CD cord-355239-fc52dn3v 40 8 genotypes genotype NNS cord-355239-fc52dn3v 40 9 , , , cord-355239-fc52dn3v 40 10 three three CD cord-355239-fc52dn3v 40 11 of of IN cord-355239-fc52dn3v 40 12 which which WDT cord-355239-fc52dn3v 40 13 ( ( -LRB- cord-355239-fc52dn3v 40 14 genogroups genogroups NNP cord-355239-fc52dn3v 40 15 I -PRON- PRP cord-355239-fc52dn3v 40 16 , , , cord-355239-fc52dn3v 40 17 II II NNP cord-355239-fc52dn3v 40 18 , , , cord-355239-fc52dn3v 40 19 and and CC cord-355239-fc52dn3v 40 20 IV IV NNP cord-355239-fc52dn3v 40 21 ) ) -RRB- cord-355239-fc52dn3v 40 22 infect infect VBP cord-355239-fc52dn3v 40 23 humans human NNS cord-355239-fc52dn3v 40 24 . . . cord-355239-fc52dn3v 41 1 Except except IN cord-355239-fc52dn3v 41 2 for for IN cord-355239-fc52dn3v 41 3 a a DT cord-355239-fc52dn3v 41 4 few few JJ cord-355239-fc52dn3v 41 5 genotypes genotype NNS cord-355239-fc52dn3v 41 6 , , , cord-355239-fc52dn3v 41 7 all all DT cord-355239-fc52dn3v 41 8 noroviruses noroviruse NNS cord-355239-fc52dn3v 41 9 bind bind VBP cord-355239-fc52dn3v 41 10 to to IN cord-355239-fc52dn3v 41 11 HBGAs hbga NNS cord-355239-fc52dn3v 41 12 including include VBG cord-355239-fc52dn3v 41 13 ABH ABH NNP cord-355239-fc52dn3v 41 14 antigens antigen NNS cord-355239-fc52dn3v 41 15 and and CC cord-355239-fc52dn3v 41 16 Lewis Lewis NNP cord-355239-fc52dn3v 41 17 antigens antigen NNS cord-355239-fc52dn3v 41 18 [ [ -LRB- cord-355239-fc52dn3v 41 19 5 5 CD cord-355239-fc52dn3v 41 20 , , , cord-355239-fc52dn3v 41 21 6 6 CD cord-355239-fc52dn3v 41 22 ] ] -RRB- cord-355239-fc52dn3v 41 23 . . . cord-355239-fc52dn3v 42 1 In in IN cord-355239-fc52dn3v 42 2 HBGAs hbga NNS cord-355239-fc52dn3v 42 3 , , , cord-355239-fc52dn3v 42 4 carbohydrate carbohydrate NN cord-355239-fc52dn3v 42 5 core core NN cord-355239-fc52dn3v 42 6 structures structure NNS cord-355239-fc52dn3v 42 7 constitute constitute VBP cord-355239-fc52dn3v 42 8 antigenically antigenically RB cord-355239-fc52dn3v 42 9 distinct distinct JJ cord-355239-fc52dn3v 42 10 phenotypes phenotype NNS cord-355239-fc52dn3v 42 11 , , , cord-355239-fc52dn3v 42 12 namely namely RB cord-355239-fc52dn3v 42 13 type type NN cord-355239-fc52dn3v 42 14 1 1 CD cord-355239-fc52dn3v 42 15 ( ( -LRB- cord-355239-fc52dn3v 42 16 Galβ1 Galβ1 NNS cord-355239-fc52dn3v 42 17 - - HYPH cord-355239-fc52dn3v 42 18 3GlcNAcβ 3glcnacβ CD cord-355239-fc52dn3v 42 19 ) ) -RRB- cord-355239-fc52dn3v 42 20 and and CC cord-355239-fc52dn3v 42 21 type type NN cord-355239-fc52dn3v 42 22 2 2 CD cord-355239-fc52dn3v 42 23 ( ( -LRB- cord-355239-fc52dn3v 42 24 Galβ1 Galβ1 NNS cord-355239-fc52dn3v 42 25 - - HYPH cord-355239-fc52dn3v 42 26 4GlcNAcβ 4glcnacβ CD cord-355239-fc52dn3v 42 27 ) ) -RRB- cord-355239-fc52dn3v 42 28 . . . cord-355239-fc52dn3v 43 1 H h NN cord-355239-fc52dn3v 43 2 antigen antigen NN cord-355239-fc52dn3v 43 3 ( ( -LRB- cord-355239-fc52dn3v 43 4 Fuc fuc NN cord-355239-fc52dn3v 43 5 - - HYPH cord-355239-fc52dn3v 43 6 α1 α1 NNP cord-355239-fc52dn3v 43 7 - - HYPH cord-355239-fc52dn3v 43 8 2Gal 2gal CD cord-355239-fc52dn3v 43 9 ) ) -RRB- cord-355239-fc52dn3v 43 10 , , , cord-355239-fc52dn3v 43 11 i.e. i.e. FW cord-355239-fc52dn3v 43 12 , , , cord-355239-fc52dn3v 43 13 O o NN cord-355239-fc52dn3v 43 14 - - HYPH cord-355239-fc52dn3v 43 15 type type NN cord-355239-fc52dn3v 43 16 antigen antigen NN cord-355239-fc52dn3v 43 17 , , , cord-355239-fc52dn3v 43 18 is be VBZ cord-355239-fc52dn3v 43 19 generated generate VBN cord-355239-fc52dn3v 43 20 by by IN cord-355239-fc52dn3v 43 21 fucose fucose JJ cord-355239-fc52dn3v 43 22 transfer transfer NN cord-355239-fc52dn3v 43 23 to to IN cord-355239-fc52dn3v 43 24 a a DT cord-355239-fc52dn3v 43 25 galactose galactose NN cord-355239-fc52dn3v 43 26 residue residue NN cord-355239-fc52dn3v 43 27 with with IN cord-355239-fc52dn3v 43 28 an an DT cord-355239-fc52dn3v 43 29 α1 α1 NN cord-355239-fc52dn3v 43 30 - - HYPH cord-355239-fc52dn3v 43 31 2 2 CD cord-355239-fc52dn3v 43 32 linkage linkage NN cord-355239-fc52dn3v 43 33 of of IN cord-355239-fc52dn3v 43 34 type type NN cord-355239-fc52dn3v 43 35 1 1 CD cord-355239-fc52dn3v 43 36 or or CC cord-355239-fc52dn3v 43 37 type type NN cord-355239-fc52dn3v 43 38 2 2 CD cord-355239-fc52dn3v 43 39 . . . cord-355239-fc52dn3v 44 1 The the DT cord-355239-fc52dn3v 44 2 A a DT cord-355239-fc52dn3v 44 3 antigen antigen NN cord-355239-fc52dn3v 44 4 ( ( -LRB- cord-355239-fc52dn3v 44 5 GalNAc GalNAc NNP cord-355239-fc52dn3v 44 6 α1 α1 JJ cord-355239-fc52dn3v 44 7 - - HYPH cord-355239-fc52dn3v 44 8 3(Fuc 3(fuc CD cord-355239-fc52dn3v 44 9 - - HYPH cord-355239-fc52dn3v 44 10 α1 α1 NN cord-355239-fc52dn3v 44 11 - - HYPH cord-355239-fc52dn3v 44 12 2)Gal 2)gal CD cord-355239-fc52dn3v 44 13 ) ) -RRB- cord-355239-fc52dn3v 44 14 and and CC cord-355239-fc52dn3v 44 15 B b NN cord-355239-fc52dn3v 44 16 antigen antigen NN cord-355239-fc52dn3v 44 17 ( ( -LRB- cord-355239-fc52dn3v 44 18 Gal Gal NNP cord-355239-fc52dn3v 44 19 α1 α1 NN cord-355239-fc52dn3v 44 20 - - HYPH cord-355239-fc52dn3v 44 21 3(Fuc 3(fuc CD cord-355239-fc52dn3v 44 22 - - HYPH cord-355239-fc52dn3v 44 23 α1 α1 NN cord-355239-fc52dn3v 44 24 - - HYPH cord-355239-fc52dn3v 44 25 2)Gal 2)gal CD cord-355239-fc52dn3v 44 26 ) ) -RRB- cord-355239-fc52dn3v 44 27 of of IN cord-355239-fc52dn3v 44 28 HBGAs hbga NNS cord-355239-fc52dn3v 44 29 are be VBP cord-355239-fc52dn3v 44 30 generated generate VBN cord-355239-fc52dn3v 44 31 by by IN cord-355239-fc52dn3v 44 32 transfer transfer NN cord-355239-fc52dn3v 44 33 of of IN cord-355239-fc52dn3v 44 34 GalNAc galnac NN cord-355239-fc52dn3v 44 35 and and CC cord-355239-fc52dn3v 44 36 Gal Gal NNP cord-355239-fc52dn3v 44 37 , , , cord-355239-fc52dn3v 44 38 respectively respectively RB cord-355239-fc52dn3v 44 39 , , , cord-355239-fc52dn3v 44 40 to to IN cord-355239-fc52dn3v 44 41 an an DT cord-355239-fc52dn3v 44 42 H h NN cord-355239-fc52dn3v 44 43 structure structure NN cord-355239-fc52dn3v 44 44 irrespective irrespective RB cord-355239-fc52dn3v 44 45 of of IN cord-355239-fc52dn3v 44 46 the the DT cord-355239-fc52dn3v 44 47 carbohydrate carbohydrate NN cord-355239-fc52dn3v 44 48 core core NN cord-355239-fc52dn3v 44 49 structure structure NN cord-355239-fc52dn3v 44 50 . . . cord-355239-fc52dn3v 45 1 FUT1 FUT1 NNP cord-355239-fc52dn3v 45 2 and and CC cord-355239-fc52dn3v 45 3 FUT2 FUT2 NNP cord-355239-fc52dn3v 45 4 are be VBP cord-355239-fc52dn3v 45 5 α1,2FUTs α1,2fut NNS cord-355239-fc52dn3v 45 6 that that WDT cord-355239-fc52dn3v 45 7 catalyze catalyze VBP cord-355239-fc52dn3v 45 8 the the DT cord-355239-fc52dn3v 45 9 transfer transfer NN cord-355239-fc52dn3v 45 10 of of IN cord-355239-fc52dn3v 45 11 Fuc Fuc NNP cord-355239-fc52dn3v 45 12 to to IN cord-355239-fc52dn3v 45 13 the the DT cord-355239-fc52dn3v 45 14 Gal Gal NNP cord-355239-fc52dn3v 45 15 residue residue NN cord-355239-fc52dn3v 45 16 of of IN cord-355239-fc52dn3v 45 17 type type NN cord-355239-fc52dn3v 45 18 1 1 CD cord-355239-fc52dn3v 45 19 and and CC cord-355239-fc52dn3v 45 20 2 2 CD cord-355239-fc52dn3v 45 21 chains chain NNS cord-355239-fc52dn3v 45 22 , , , cord-355239-fc52dn3v 45 23 thereby thereby RB cord-355239-fc52dn3v 45 24 resulting result VBG cord-355239-fc52dn3v 45 25 in in IN cord-355239-fc52dn3v 45 26 the the DT cord-355239-fc52dn3v 45 27 synthesis synthesis NN cord-355239-fc52dn3v 45 28 of of IN cord-355239-fc52dn3v 45 29 H h NN cord-355239-fc52dn3v 45 30 type type NN cord-355239-fc52dn3v 45 31 1 1 CD cord-355239-fc52dn3v 45 32 and and CC cord-355239-fc52dn3v 45 33 H h NN cord-355239-fc52dn3v 45 34 type type NN cord-355239-fc52dn3v 45 35 2 2 CD cord-355239-fc52dn3v 45 36 , , , cord-355239-fc52dn3v 45 37 respectively respectively RB cord-355239-fc52dn3v 45 38 . . . cord-355239-fc52dn3v 46 1 HBGAs hbga NNS cord-355239-fc52dn3v 46 2 are be VBP cord-355239-fc52dn3v 46 3 found find VBN cord-355239-fc52dn3v 46 4 in in IN cord-355239-fc52dn3v 46 5 saliva saliva NN cord-355239-fc52dn3v 46 6 and and CC cord-355239-fc52dn3v 46 7 mucosal mucosal JJ cord-355239-fc52dn3v 46 8 secretions secretion NNS cord-355239-fc52dn3v 46 9 from from IN cord-355239-fc52dn3v 46 10 the the DT cord-355239-fc52dn3v 46 11 intestinal intestinal JJ cord-355239-fc52dn3v 46 12 epithelial epithelial JJ cord-355239-fc52dn3v 46 13 cells cell NNS cord-355239-fc52dn3v 46 14 of of IN cord-355239-fc52dn3v 46 15 secretors secretor NNS cord-355239-fc52dn3v 46 16 ( ( -LRB- cord-355239-fc52dn3v 46 17 i.e. i.e. FW cord-355239-fc52dn3v 46 18 , , , cord-355239-fc52dn3v 46 19 individuals individual NNS cord-355239-fc52dn3v 46 20 who who WP cord-355239-fc52dn3v 46 21 have have VBP cord-355239-fc52dn3v 46 22 the the DT cord-355239-fc52dn3v 46 23 FUT2 FUT2 NNP cord-355239-fc52dn3v 46 24 gene gene NN cord-355239-fc52dn3v 46 25 that that WDT cord-355239-fc52dn3v 46 26 encodes encode VBZ cord-355239-fc52dn3v 46 27 a a DT cord-355239-fc52dn3v 46 28 fucosyltransferase fucosyltransferase NN cord-355239-fc52dn3v 46 29 ) ) -RRB- cord-355239-fc52dn3v 46 30 . . . cord-355239-fc52dn3v 47 1 Non Non NNS cord-355239-fc52dn3v 47 2 - - NNS cord-355239-fc52dn3v 47 3 secretors secretor NNS cord-355239-fc52dn3v 47 4 , , , cord-355239-fc52dn3v 47 5 who who WP cord-355239-fc52dn3v 47 6 do do VBP cord-355239-fc52dn3v 47 7 not not RB cord-355239-fc52dn3v 47 8 express express VB cord-355239-fc52dn3v 47 9 FUT2 FUT2 NNP cord-355239-fc52dn3v 47 10 fucosyltransferase fucosyltransferase CC cord-355239-fc52dn3v 47 11 and and CC cord-355239-fc52dn3v 47 12 consequently consequently RB cord-355239-fc52dn3v 47 13 do do VBP cord-355239-fc52dn3v 47 14 not not RB cord-355239-fc52dn3v 47 15 express express VB cord-355239-fc52dn3v 47 16 H h NN cord-355239-fc52dn3v 47 17 type type NN cord-355239-fc52dn3v 47 18 1 1 CD cord-355239-fc52dn3v 47 19 or or CC cord-355239-fc52dn3v 47 20 Le Le NNP cord-355239-fc52dn3v 47 21 b b NNP cord-355239-fc52dn3v 47 22 in in IN cord-355239-fc52dn3v 47 23 the the DT cord-355239-fc52dn3v 47 24 gut gut NN cord-355239-fc52dn3v 47 25 , , , cord-355239-fc52dn3v 47 26 are be VBP cord-355239-fc52dn3v 47 27 not not RB cord-355239-fc52dn3v 47 28 infected infect VBN cord-355239-fc52dn3v 47 29 after after IN cord-355239-fc52dn3v 47 30 challenge challenge NN cord-355239-fc52dn3v 47 31 with with IN cord-355239-fc52dn3v 47 32 the the DT cord-355239-fc52dn3v 47 33 prototype prototype NN cord-355239-fc52dn3v 47 34 strain strain NN cord-355239-fc52dn3v 47 35 of of IN cord-355239-fc52dn3v 47 36 norovirus norovirus NN cord-355239-fc52dn3v 47 37 , , , cord-355239-fc52dn3v 47 38 NV/68 NV/68 NNP cord-355239-fc52dn3v 47 39 [ [ -LRB- cord-355239-fc52dn3v 47 40 5 5 CD cord-355239-fc52dn3v 47 41 , , , cord-355239-fc52dn3v 47 42 6 6 CD cord-355239-fc52dn3v 47 43 ] ] -RRB- cord-355239-fc52dn3v 47 44 . . . cord-355239-fc52dn3v 48 1 Moreover moreover RB cord-355239-fc52dn3v 48 2 , , , cord-355239-fc52dn3v 48 3 the the DT cord-355239-fc52dn3v 48 4 association association NN cord-355239-fc52dn3v 48 5 data datum NNS cord-355239-fc52dn3v 48 6 between between IN cord-355239-fc52dn3v 48 7 blood blood NN cord-355239-fc52dn3v 48 8 type type NN cord-355239-fc52dn3v 48 9 and and CC cord-355239-fc52dn3v 48 10 NV/68 nv/68 NN cord-355239-fc52dn3v 48 11 infection infection NN cord-355239-fc52dn3v 48 12 showed show VBD cord-355239-fc52dn3v 48 13 that that IN cord-355239-fc52dn3v 48 14 , , , cord-355239-fc52dn3v 48 15 among among IN cord-355239-fc52dn3v 48 16 secretor secretor NNP cord-355239-fc52dn3v 48 17 volunteers volunteer NNS cord-355239-fc52dn3v 48 18 , , , cord-355239-fc52dn3v 48 19 blood blood NN cord-355239-fc52dn3v 48 20 groups group NNS cord-355239-fc52dn3v 48 21 O o NN cord-355239-fc52dn3v 48 22 and and CC cord-355239-fc52dn3v 48 23 A a DT cord-355239-fc52dn3v 48 24 were be VBD cord-355239-fc52dn3v 48 25 associated associate VBN cord-355239-fc52dn3v 48 26 with with IN cord-355239-fc52dn3v 48 27 an an DT cord-355239-fc52dn3v 48 28 increased increase VBN cord-355239-fc52dn3v 48 29 risk risk NN cord-355239-fc52dn3v 48 30 of of IN cord-355239-fc52dn3v 48 31 infection infection NN cord-355239-fc52dn3v 48 32 , , , cord-355239-fc52dn3v 48 33 while while IN cord-355239-fc52dn3v 48 34 blood blood NN cord-355239-fc52dn3v 48 35 group group NN cord-355239-fc52dn3v 48 36 B B NNP cord-355239-fc52dn3v 48 37 was be VBD cord-355239-fc52dn3v 48 38 associated associate VBN cord-355239-fc52dn3v 48 39 with with IN cord-355239-fc52dn3v 48 40 a a DT cord-355239-fc52dn3v 48 41 decreased decreased JJ cord-355239-fc52dn3v 48 42 risk risk NN cord-355239-fc52dn3v 48 43 . . . cord-355239-fc52dn3v 49 1 On on IN cord-355239-fc52dn3v 49 2 the the DT cord-355239-fc52dn3v 49 3 other other JJ cord-355239-fc52dn3v 49 4 hand hand NN cord-355239-fc52dn3v 49 5 , , , cord-355239-fc52dn3v 49 6 epidemiological epidemiological JJ cord-355239-fc52dn3v 49 7 studies study NNS cord-355239-fc52dn3v 49 8 have have VBP cord-355239-fc52dn3v 49 9 shown show VBN cord-355239-fc52dn3v 49 10 that that IN cord-355239-fc52dn3v 49 11 some some DT cord-355239-fc52dn3v 49 12 norovirus norovirus NN cord-355239-fc52dn3v 49 13 strains strain NNS cord-355239-fc52dn3v 49 14 with with IN cord-355239-fc52dn3v 49 15 ABH ABH NNP cord-355239-fc52dn3v 49 16 phenotypes phenotype NNS cord-355239-fc52dn3v 49 17 that that WDT cord-355239-fc52dn3v 49 18 differ differ VBP cord-355239-fc52dn3v 49 19 from from IN cord-355239-fc52dn3v 49 20 that that DT cord-355239-fc52dn3v 49 21 of of IN cord-355239-fc52dn3v 49 22 NV/68 NV/68 NNS cord-355239-fc52dn3v 49 23 can can MD cord-355239-fc52dn3v 49 24 infect infect VB cord-355239-fc52dn3v 49 25 individuals individual NNS cord-355239-fc52dn3v 49 26 . . . cord-355239-fc52dn3v 50 1 GII/4 GII/4 NNP cord-355239-fc52dn3v 50 2 , , , cord-355239-fc52dn3v 50 3 which which WDT cord-355239-fc52dn3v 50 4 is be VBZ cord-355239-fc52dn3v 50 5 known know VBN cord-355239-fc52dn3v 50 6 as as IN cord-355239-fc52dn3v 50 7 a a DT cord-355239-fc52dn3v 50 8 global global JJ cord-355239-fc52dn3v 50 9 epidemic epidemic NN cord-355239-fc52dn3v 50 10 strain strain NN cord-355239-fc52dn3v 50 11 , , , cord-355239-fc52dn3v 50 12 binds bind VBZ cord-355239-fc52dn3v 50 13 more more JJR cord-355239-fc52dn3v 50 14 HBGAs hbga NNS cord-355239-fc52dn3v 50 15 than than IN cord-355239-fc52dn3v 50 16 other other JJ cord-355239-fc52dn3v 50 17 strains strain NNS cord-355239-fc52dn3v 50 18 , , , cord-355239-fc52dn3v 50 19 suggesting suggest VBG cord-355239-fc52dn3v 50 20 that that IN cord-355239-fc52dn3v 50 21 the the DT cord-355239-fc52dn3v 50 22 strength strength NN cord-355239-fc52dn3v 50 23 of of IN cord-355239-fc52dn3v 50 24 transmission transmission NN cord-355239-fc52dn3v 50 25 of of IN cord-355239-fc52dn3v 50 26 GII/4 GII/4 NNP cord-355239-fc52dn3v 50 27 strains strain NNS cord-355239-fc52dn3v 50 28 is be VBZ cord-355239-fc52dn3v 50 29 related relate VBN cord-355239-fc52dn3v 50 30 to to IN cord-355239-fc52dn3v 50 31 the the DT cord-355239-fc52dn3v 50 32 broad broad JJ cord-355239-fc52dn3v 50 33 recognition recognition NN cord-355239-fc52dn3v 50 34 of of IN cord-355239-fc52dn3v 50 35 HBGAs hbga NNS cord-355239-fc52dn3v 50 36 [ [ -LRB- cord-355239-fc52dn3v 50 37 6 6 CD cord-355239-fc52dn3v 50 38 ] ] -RRB- cord-355239-fc52dn3v 50 39 . . . cord-355239-fc52dn3v 51 1 The the DT cord-355239-fc52dn3v 51 2 recognition recognition NN cord-355239-fc52dn3v 51 3 sites site NNS cord-355239-fc52dn3v 51 4 on on IN cord-355239-fc52dn3v 51 5 HBGAs hbga NNS cord-355239-fc52dn3v 51 6 by by IN cord-355239-fc52dn3v 51 7 norovirus norovirus NN cord-355239-fc52dn3v 51 8 have have VBP cord-355239-fc52dn3v 51 9 been be VBN cord-355239-fc52dn3v 51 10 classified classify VBN cord-355239-fc52dn3v 51 11 according accord VBG cord-355239-fc52dn3v 51 12 to to IN cord-355239-fc52dn3v 51 13 the the DT cord-355239-fc52dn3v 51 14 interaction interaction NN cord-355239-fc52dn3v 51 15 of of IN cord-355239-fc52dn3v 51 16 the the DT cord-355239-fc52dn3v 51 17 virus virus NN cord-355239-fc52dn3v 51 18 with with IN cord-355239-fc52dn3v 51 19 the the DT cord-355239-fc52dn3v 51 20 H H NNP cord-355239-fc52dn3v 51 21 , , , cord-355239-fc52dn3v 51 22 A A NNP cord-355239-fc52dn3v 51 23 , , , cord-355239-fc52dn3v 51 24 B b NN cord-355239-fc52dn3v 51 25 , , , cord-355239-fc52dn3v 51 26 and and CC cord-355239-fc52dn3v 51 27 Le Le NNP cord-355239-fc52dn3v 51 28 epitopes epitopes NNP cord-355239-fc52dn3v 51 29 ( ( -LRB- cord-355239-fc52dn3v 51 30 Fig Fig NNP cord-355239-fc52dn3v 51 31 . . . cord-355239-fc52dn3v 51 32 1 1 CD cord-355239-fc52dn3v 51 33 ) ) -RRB- cord-355239-fc52dn3v 51 34 [ [ -LRB- cord-355239-fc52dn3v 51 35 6 6 CD cord-355239-fc52dn3v 51 36 , , , cord-355239-fc52dn3v 51 37 7 7 CD cord-355239-fc52dn3v 51 38 ] ] -RRB- cord-355239-fc52dn3v 51 39 . . . cord-355239-fc52dn3v 52 1 HBGAs hbga NNS cord-355239-fc52dn3v 52 2 are be VBP cord-355239-fc52dn3v 52 3 important important JJ cord-355239-fc52dn3v 52 4 factors factor NNS cord-355239-fc52dn3v 52 5 for for IN cord-355239-fc52dn3v 52 6 determining determine VBG cord-355239-fc52dn3v 52 7 host host NN cord-355239-fc52dn3v 52 8 specificity specificity NN cord-355239-fc52dn3v 52 9 , , , cord-355239-fc52dn3v 52 10 although although IN cord-355239-fc52dn3v 52 11 it -PRON- PRP cord-355239-fc52dn3v 52 12 is be VBZ cord-355239-fc52dn3v 52 13 still still RB cord-355239-fc52dn3v 52 14 unclear unclear JJ cord-355239-fc52dn3v 52 15 whether whether IN cord-355239-fc52dn3v 52 16 HBGAs hbga NNS cord-355239-fc52dn3v 52 17 act act VBP cord-355239-fc52dn3v 52 18 as as IN cord-355239-fc52dn3v 52 19 the the DT cord-355239-fc52dn3v 52 20 primary primary JJ cord-355239-fc52dn3v 52 21 receptor receptor NN cord-355239-fc52dn3v 52 22 or or CC cord-355239-fc52dn3v 52 23 enhance enhance VB cord-355239-fc52dn3v 52 24 norovirus norovirus NN cord-355239-fc52dn3v 52 25 infectivity infectivity NN cord-355239-fc52dn3v 52 26 . . . cord-355239-fc52dn3v 53 1 Researchers researcher NNS cord-355239-fc52dn3v 53 2 including include VBG cord-355239-fc52dn3v 53 3 ourselves -PRON- PRP cord-355239-fc52dn3v 53 4 have have VBP cord-355239-fc52dn3v 53 5 demonstrated demonstrate VBN cord-355239-fc52dn3v 53 6 that that IN cord-355239-fc52dn3v 53 7 feline feline JJ cord-355239-fc52dn3v 53 8 calicivirus calicivirus NNP cord-355239-fc52dn3v 53 9 ( ( -LRB- cord-355239-fc52dn3v 53 10 FCV FCV NNP cord-355239-fc52dn3v 53 11 ) ) -RRB- cord-355239-fc52dn3v 53 12 , , , cord-355239-fc52dn3v 53 13 a a DT cord-355239-fc52dn3v 53 14 member member NN cord-355239-fc52dn3v 53 15 of of IN cord-355239-fc52dn3v 53 16 the the DT cord-355239-fc52dn3v 53 17 genus genus JJ cord-355239-fc52dn3v 53 18 Vesivirus Vesivirus NNP cord-355239-fc52dn3v 53 19 , , , cord-355239-fc52dn3v 53 20 infects infect VBZ cord-355239-fc52dn3v 53 21 the the DT cord-355239-fc52dn3v 53 22 upper upper JJ cord-355239-fc52dn3v 53 23 respiratory respiratory JJ cord-355239-fc52dn3v 53 24 tract tract NN cord-355239-fc52dn3v 53 25 by by IN cord-355239-fc52dn3v 53 26 attaching attach VBG cord-355239-fc52dn3v 53 27 to to IN cord-355239-fc52dn3v 53 28 α2 α2 NN cord-355239-fc52dn3v 53 29 - - HYPH cord-355239-fc52dn3v 53 30 6linked 6linked CD cord-355239-fc52dn3v 53 31 sialic sialic JJ cord-355239-fc52dn3v 53 32 acids acid NNS cord-355239-fc52dn3v 53 33 and and CC cord-355239-fc52dn3v 53 34 using use VBG cord-355239-fc52dn3v 53 35 junctional junctional JJ cord-355239-fc52dn3v 53 36 adhesion adhesion NN cord-355239-fc52dn3v 53 37 molecule-1 molecule-1 NNP cord-355239-fc52dn3v 53 38 for for IN cord-355239-fc52dn3v 53 39 internalization internalization NN cord-355239-fc52dn3v 53 40 [ [ -LRB- cord-355239-fc52dn3v 53 41 8 8 CD cord-355239-fc52dn3v 53 42 , , , cord-355239-fc52dn3v 53 43 9 9 CD cord-355239-fc52dn3v 53 44 ] ] -RRB- cord-355239-fc52dn3v 53 45 . . . cord-355239-fc52dn3v 54 1 It -PRON- PRP cord-355239-fc52dn3v 54 2 is be VBZ cord-355239-fc52dn3v 54 3 comparatively comparatively RB cord-355239-fc52dn3v 54 4 easy easy JJ cord-355239-fc52dn3v 54 5 to to TO cord-355239-fc52dn3v 54 6 study study VB cord-355239-fc52dn3v 54 7 the the DT cord-355239-fc52dn3v 54 8 life life NN cord-355239-fc52dn3v 54 9 cycle cycle NN cord-355239-fc52dn3v 54 10 of of IN cord-355239-fc52dn3v 54 11 FCV FCV NNP cord-355239-fc52dn3v 54 12 because because IN cord-355239-fc52dn3v 54 13 the the DT cord-355239-fc52dn3v 54 14 virus virus NN cord-355239-fc52dn3v 54 15 replicates replicate VBZ cord-355239-fc52dn3v 54 16 efficiently efficiently RB cord-355239-fc52dn3v 54 17 in in IN cord-355239-fc52dn3v 54 18 cell cell NN cord-355239-fc52dn3v 54 19 culture culture NN cord-355239-fc52dn3v 54 20 without without IN cord-355239-fc52dn3v 54 21 specific specific JJ cord-355239-fc52dn3v 54 22 supplementation supplementation NN cord-355239-fc52dn3v 54 23 , , , cord-355239-fc52dn3v 54 24 whereas whereas IN cord-355239-fc52dn3v 54 25 noroviruses noroviruse NNS cord-355239-fc52dn3v 54 26 are be VBP cord-355239-fc52dn3v 54 27 not not RB cord-355239-fc52dn3v 54 28 cultivable cultivable JJ cord-355239-fc52dn3v 54 29 in in IN cord-355239-fc52dn3v 54 30 cell cell NN cord-355239-fc52dn3v 54 31 culture culture NN cord-355239-fc52dn3v 54 32 . . . cord-355239-fc52dn3v 55 1 Carbohydrates carbohydrate NNS cord-355239-fc52dn3v 55 2 also also RB cord-355239-fc52dn3v 55 3 function function VBP cord-355239-fc52dn3v 55 4 as as IN cord-355239-fc52dn3v 55 5 receptors receptor NNS cord-355239-fc52dn3v 55 6 for for IN cord-355239-fc52dn3v 55 7 bacterial bacterial JJ cord-355239-fc52dn3v 55 8 attachment attachment NN cord-355239-fc52dn3v 55 9 at at IN cord-355239-fc52dn3v 55 10 the the DT cord-355239-fc52dn3v 55 11 initial initial JJ cord-355239-fc52dn3v 55 12 step step NN cord-355239-fc52dn3v 55 13 of of IN cord-355239-fc52dn3v 55 14 infection infection NN cord-355239-fc52dn3v 55 15 . . . cord-355239-fc52dn3v 56 1 Here here RB cord-355239-fc52dn3v 56 2 , , , cord-355239-fc52dn3v 56 3 we -PRON- PRP cord-355239-fc52dn3v 56 4 describe describe VBP cord-355239-fc52dn3v 56 5 the the DT cord-355239-fc52dn3v 56 6 role role NN cord-355239-fc52dn3v 56 7 of of IN cord-355239-fc52dn3v 56 8 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 56 9 in in IN cord-355239-fc52dn3v 56 10 bacterial bacterial JJ cord-355239-fc52dn3v 56 11 infections infection NNS cord-355239-fc52dn3v 56 12 , , , cord-355239-fc52dn3v 56 13 focusing focus VBG cord-355239-fc52dn3v 56 14 on on IN cord-355239-fc52dn3v 56 15 Salmonella Salmonella NNP cord-355239-fc52dn3v 56 16 enterica enterica NN cord-355239-fc52dn3v 56 17 and and CC cord-355239-fc52dn3v 56 18 several several JJ cord-355239-fc52dn3v 56 19 assortative assortative NN cord-355239-fc52dn3v 56 20 bacterial bacterial JJ cord-355239-fc52dn3v 56 21 species specie NNS cord-355239-fc52dn3v 56 22 that that WDT cord-355239-fc52dn3v 56 23 produce produce VBP cord-355239-fc52dn3v 56 24 a a DT cord-355239-fc52dn3v 56 25 variety variety NN cord-355239-fc52dn3v 56 26 of of IN cord-355239-fc52dn3v 56 27 fimbrial fimbrial JJ cord-355239-fc52dn3v 56 28 adhesions adhesion NNS cord-355239-fc52dn3v 56 29 ( ( -LRB- cord-355239-fc52dn3v 56 30 Fig Fig NNP cord-355239-fc52dn3v 56 31 . . NNP cord-355239-fc52dn3v 56 32 2 2 CD cord-355239-fc52dn3v 56 33 ) ) -RRB- cord-355239-fc52dn3v 56 34 . . . cord-355239-fc52dn3v 57 1 Salmonella salmonella NN cord-355239-fc52dn3v 57 2 strains strain NNS cord-355239-fc52dn3v 57 3 cause cause VBP cord-355239-fc52dn3v 57 4 disease disease NN cord-355239-fc52dn3v 57 5 in in IN cord-355239-fc52dn3v 57 6 diverse diverse JJ cord-355239-fc52dn3v 57 7 mammalian mammalian JJ cord-355239-fc52dn3v 57 8 hosts host NNS cord-355239-fc52dn3v 57 9 . . . cord-355239-fc52dn3v 58 1 Some some DT cord-355239-fc52dn3v 58 2 Salmonella Salmonella NNP cord-355239-fc52dn3v 58 3 strains strain NNS cord-355239-fc52dn3v 58 4 have have VBP cord-355239-fc52dn3v 58 5 a a DT cord-355239-fc52dn3v 58 6 narrow narrow JJ cord-355239-fc52dn3v 58 7 host host NN cord-355239-fc52dn3v 58 8 range range NN cord-355239-fc52dn3v 58 9 , , , cord-355239-fc52dn3v 58 10 such such JJ cord-355239-fc52dn3v 58 11 as as IN cord-355239-fc52dn3v 58 12 Salmonella Salmonella NNP cord-355239-fc52dn3v 58 13 enterica enterica NNP cord-355239-fc52dn3v 59 1 serovar serovar NNP cord-355239-fc52dn3v 59 2 Typhi Typhi NNP cord-355239-fc52dn3v 59 3 ( ( -LRB- cord-355239-fc52dn3v 59 4 S. S. NNP cord-355239-fc52dn3v 59 5 typhi typhi NNP cord-355239-fc52dn3v 59 6 ) ) -RRB- cord-355239-fc52dn3v 59 7 and and CC cord-355239-fc52dn3v 59 8 serovar serovar NNP cord-355239-fc52dn3v 59 9 Paratyphi Paratyphi NNP cord-355239-fc52dn3v 59 10 ( ( -LRB- cord-355239-fc52dn3v 59 11 S. S. NNP cord-355239-fc52dn3v 59 12 paratyphi paratyphi NNP cord-355239-fc52dn3v 59 13 ) ) -RRB- cord-355239-fc52dn3v 59 14 , , , cord-355239-fc52dn3v 59 15 which which WDT cord-355239-fc52dn3v 59 16 cause cause VBP cord-355239-fc52dn3v 59 17 disease disease NN cord-355239-fc52dn3v 59 18 only only RB cord-355239-fc52dn3v 59 19 in in IN cord-355239-fc52dn3v 59 20 humans human NNS cord-355239-fc52dn3v 59 21 , , , cord-355239-fc52dn3v 59 22 whereas whereas IN cord-355239-fc52dn3v 59 23 strains strain NNS cord-355239-fc52dn3v 59 24 such such JJ cord-355239-fc52dn3v 59 25 as as IN cord-355239-fc52dn3v 59 26 Salmonella Salmonella NNP cord-355239-fc52dn3v 59 27 enterica enterica NNP cord-355239-fc52dn3v 60 1 serovar serovar NNP cord-355239-fc52dn3v 60 2 Typhimurium Typhimurium NNP cord-355239-fc52dn3v 60 3 ( ( -LRB- cord-355239-fc52dn3v 60 4 S. S. NNP cord-355239-fc52dn3v 60 5 typhimurium typhimurium NNP cord-355239-fc52dn3v 60 6 ) ) -RRB- cord-355239-fc52dn3v 60 7 and and CC cord-355239-fc52dn3v 60 8 serovar serovar NNP cord-355239-fc52dn3v 60 9 Enteritidis Enteritidis NNP cord-355239-fc52dn3v 60 10 ( ( -LRB- cord-355239-fc52dn3v 60 11 S. S. NNP cord-355239-fc52dn3v 60 12 entertitidis entertitidis NNP cord-355239-fc52dn3v 60 13 ) ) -RRB- cord-355239-fc52dn3v 61 1 cause cause VB cord-355239-fc52dn3v 61 2 infection infection NN cord-355239-fc52dn3v 61 3 in in IN cord-355239-fc52dn3v 61 4 numerous numerous JJ cord-355239-fc52dn3v 61 5 species specie NNS cord-355239-fc52dn3v 61 6 including include VBG cord-355239-fc52dn3v 61 7 mice mice NN cord-355239-fc52dn3v 61 8 , , , cord-355239-fc52dn3v 61 9 poultry poultry NN cord-355239-fc52dn3v 61 10 , , , cord-355239-fc52dn3v 61 11 pigs pig NNS cord-355239-fc52dn3v 61 12 , , , cord-355239-fc52dn3v 61 13 sheep sheep NN cord-355239-fc52dn3v 61 14 , , , cord-355239-fc52dn3v 61 15 cattle cattle NNS cord-355239-fc52dn3v 61 16 , , , cord-355239-fc52dn3v 61 17 horses horse NNS cord-355239-fc52dn3v 61 18 and and CC cord-355239-fc52dn3v 61 19 humans human NNS cord-355239-fc52dn3v 61 20 [ [ -LRB- cord-355239-fc52dn3v 61 21 2 2 CD cord-355239-fc52dn3v 61 22 ] ] -RRB- cord-355239-fc52dn3v 61 23 . . . cord-355239-fc52dn3v 62 1 Infected infect VBN cord-355239-fc52dn3v 62 2 orally orally RB cord-355239-fc52dn3v 62 3 , , , cord-355239-fc52dn3v 62 4 Salmonella salmonella NN cord-355239-fc52dn3v 62 5 reach reach VBP cord-355239-fc52dn3v 62 6 the the DT cord-355239-fc52dn3v 62 7 intestinal intestinal JJ cord-355239-fc52dn3v 62 8 tract tract NN cord-355239-fc52dn3v 62 9 and and CC cord-355239-fc52dn3v 62 10 then then RB cord-355239-fc52dn3v 62 11 mainly mainly RB cord-355239-fc52dn3v 62 12 attach attach VB cord-355239-fc52dn3v 62 13 to to IN cord-355239-fc52dn3v 62 14 the the DT cord-355239-fc52dn3v 62 15 M M NNP cord-355239-fc52dn3v 62 16 cells cell NNS cord-355239-fc52dn3v 62 17 of of IN cord-355239-fc52dn3v 62 18 the the DT cord-355239-fc52dn3v 62 19 intestinal intestinal JJ cord-355239-fc52dn3v 62 20 epithelium epithelium NN cord-355239-fc52dn3v 62 21 to to TO cord-355239-fc52dn3v 62 22 initiate initiate VB cord-355239-fc52dn3v 62 23 invasion invasion NN cord-355239-fc52dn3v 62 24 [ [ -LRB- cord-355239-fc52dn3v 62 25 10 10 CD cord-355239-fc52dn3v 62 26 ] ] -RRB- cord-355239-fc52dn3v 62 27 . . . cord-355239-fc52dn3v 63 1 After after IN cord-355239-fc52dn3v 63 2 colonization colonization NN cord-355239-fc52dn3v 63 3 of of IN cord-355239-fc52dn3v 63 4 the the DT cord-355239-fc52dn3v 63 5 intestinal intestinal JJ cord-355239-fc52dn3v 63 6 epithelium epithelium NN cord-355239-fc52dn3v 63 7 , , , cord-355239-fc52dn3v 63 8 Typhoid Typhoid NNP cord-355239-fc52dn3v 63 9 Salmonella Salmonella NNP cord-355239-fc52dn3v 63 10 , , , cord-355239-fc52dn3v 63 11 S. S. NNP cord-355239-fc52dn3v 63 12 typhi typhi NNP cord-355239-fc52dn3v 63 13 and and CC cord-355239-fc52dn3v 63 14 S. S. NNP cord-355239-fc52dn3v 63 15 paratyphi paratyphi NNS cord-355239-fc52dn3v 63 16 , , , cord-355239-fc52dn3v 63 17 invade invade VBP cord-355239-fc52dn3v 63 18 M M NNP cord-355239-fc52dn3v 63 19 cells cell NNS cord-355239-fc52dn3v 63 20 . . . cord-355239-fc52dn3v 64 1 However however RB cord-355239-fc52dn3v 64 2 , , , cord-355239-fc52dn3v 64 3 S. S. NNP cord-355239-fc52dn3v 64 4 typhi typhi NNP cord-355239-fc52dn3v 64 5 and and CC cord-355239-fc52dn3v 64 6 S. S. NNP cord-355239-fc52dn3v 64 7 paratyphi paratyphi NNS cord-355239-fc52dn3v 64 8 can can MD cord-355239-fc52dn3v 64 9 also also RB cord-355239-fc52dn3v 64 10 survive survive VB cord-355239-fc52dn3v 64 11 being be VBG cord-355239-fc52dn3v 64 12 engulfed engulf VBN cord-355239-fc52dn3v 64 13 by by IN cord-355239-fc52dn3v 64 14 macrophages macrophage NNS cord-355239-fc52dn3v 64 15 , , , cord-355239-fc52dn3v 64 16 which which WDT cord-355239-fc52dn3v 64 17 then then RB cord-355239-fc52dn3v 64 18 spread spread VBD cord-355239-fc52dn3v 64 19 throughout throughout IN cord-355239-fc52dn3v 64 20 the the DT cord-355239-fc52dn3v 64 21 body body NN cord-355239-fc52dn3v 64 22 via via IN cord-355239-fc52dn3v 64 23 the the DT cord-355239-fc52dn3v 64 24 lymphatic lymphatic NN cord-355239-fc52dn3v 64 25 and and CC cord-355239-fc52dn3v 64 26 blood blood NN cord-355239-fc52dn3v 64 27 systems system NNS cord-355239-fc52dn3v 64 28 . . . cord-355239-fc52dn3v 65 1 Non non JJ cord-355239-fc52dn3v 65 2 - - JJ cord-355239-fc52dn3v 65 3 typhoidal typhoidal JJ cord-355239-fc52dn3v 65 4 Salmonella Salmonella NNP cord-355239-fc52dn3v 65 5 , , , cord-355239-fc52dn3v 65 6 S. S. NNP cord-355239-fc52dn3v 65 7 typhimurium typhimurium NN cord-355239-fc52dn3v 65 8 and and CC cord-355239-fc52dn3v 65 9 S. S. NNP cord-355239-fc52dn3v 65 10 enteritidis enteritidis NN cord-355239-fc52dn3v 65 11 can can MD cord-355239-fc52dn3v 65 12 not not RB cord-355239-fc52dn3v 65 13 survive survive VB cord-355239-fc52dn3v 65 14 within within IN cord-355239-fc52dn3v 65 15 macrophages macrophage NNS cord-355239-fc52dn3v 65 16 ( ( -LRB- cord-355239-fc52dn3v 65 17 Fig Fig NNP cord-355239-fc52dn3v 65 18 . . . cord-355239-fc52dn3v 65 19 3 3 CD cord-355239-fc52dn3v 65 20 ) ) -RRB- cord-355239-fc52dn3v 65 21 . . . cord-355239-fc52dn3v 66 1 They -PRON- PRP cord-355239-fc52dn3v 66 2 cause cause VBP cord-355239-fc52dn3v 66 3 gastroenteritis gastroenteritis NN cord-355239-fc52dn3v 66 4 in in IN cord-355239-fc52dn3v 66 5 humans human NNS cord-355239-fc52dn3v 66 6 and and CC cord-355239-fc52dn3v 66 7 animals animal NNS cord-355239-fc52dn3v 66 8 by by IN cord-355239-fc52dn3v 66 9 colonizing colonize VBG cord-355239-fc52dn3v 66 10 the the DT cord-355239-fc52dn3v 66 11 intestinal intestinal JJ cord-355239-fc52dn3v 66 12 epithelium epithelium NN cord-355239-fc52dn3v 66 13 and and CC cord-355239-fc52dn3v 66 14 then then RB cord-355239-fc52dn3v 66 15 invading invade VBG cord-355239-fc52dn3v 66 16 and and CC cord-355239-fc52dn3v 66 17 destroying destroy VBG cord-355239-fc52dn3v 66 18 the the DT cord-355239-fc52dn3v 66 19 M M NNP cord-355239-fc52dn3v 66 20 cells cell NNS cord-355239-fc52dn3v 66 21 and and CC cord-355239-fc52dn3v 66 22 enterocytes enterocytes NNPS cord-355239-fc52dn3v 66 23 [ [ -LRB- cord-355239-fc52dn3v 66 24 2 2 CD cord-355239-fc52dn3v 66 25 ] ] -RRB- cord-355239-fc52dn3v 66 26 . . . cord-355239-fc52dn3v 67 1 Bacterial bacterial JJ cord-355239-fc52dn3v 67 2 adherence adherence NN cord-355239-fc52dn3v 67 3 requires require VBZ cord-355239-fc52dn3v 67 4 both both DT cord-355239-fc52dn3v 67 5 specific specific JJ cord-355239-fc52dn3v 67 6 and and CC cord-355239-fc52dn3v 67 7 nonspecific nonspecific JJ cord-355239-fc52dn3v 67 8 interactions interaction NNS cord-355239-fc52dn3v 67 9 . . . cord-355239-fc52dn3v 68 1 In in IN cord-355239-fc52dn3v 68 2 the the DT cord-355239-fc52dn3v 68 3 case case NN cord-355239-fc52dn3v 68 4 of of IN cord-355239-fc52dn3v 68 5 Salmonella Salmonella NNP cord-355239-fc52dn3v 68 6 , , , cord-355239-fc52dn3v 68 7 the the DT cord-355239-fc52dn3v 68 8 negative negative JJ cord-355239-fc52dn3v 68 9 charge charge NN cord-355239-fc52dn3v 68 10 produced produce VBN cord-355239-fc52dn3v 68 11 by by IN cord-355239-fc52dn3v 68 12 sialic sialic JJ cord-355239-fc52dn3v 68 13 acid acid NN cord-355239-fc52dn3v 68 14 on on IN cord-355239-fc52dn3v 68 15 the the DT cord-355239-fc52dn3v 68 16 surface surface NN cord-355239-fc52dn3v 68 17 of of IN cord-355239-fc52dn3v 68 18 the the DT cord-355239-fc52dn3v 68 19 host host NN cord-355239-fc52dn3v 68 20 cell cell NN cord-355239-fc52dn3v 68 21 is be VBZ cord-355239-fc52dn3v 68 22 required require VBN cord-355239-fc52dn3v 68 23 as as IN cord-355239-fc52dn3v 68 24 a a DT cord-355239-fc52dn3v 68 25 non non JJ cord-355239-fc52dn3v 68 26 - - JJ cord-355239-fc52dn3v 68 27 specific specific JJ cord-355239-fc52dn3v 68 28 adherence adherence NN cord-355239-fc52dn3v 68 29 factor factor NN cord-355239-fc52dn3v 68 30 [ [ -LRB- cord-355239-fc52dn3v 68 31 11 11 CD cord-355239-fc52dn3v 68 32 ] ] -RRB- cord-355239-fc52dn3v 68 33 . . . cord-355239-fc52dn3v 69 1 For for IN cord-355239-fc52dn3v 69 2 their -PRON- PRP$ cord-355239-fc52dn3v 69 3 specific specific JJ cord-355239-fc52dn3v 69 4 interactions interaction NNS cord-355239-fc52dn3v 69 5 , , , cord-355239-fc52dn3v 69 6 Salmonella salmonella NN cord-355239-fc52dn3v 69 7 and and CC cord-355239-fc52dn3v 69 8 assor assor NN cord-355239-fc52dn3v 69 9 - - HYPH cord-355239-fc52dn3v 69 10 tative tative NN cord-355239-fc52dn3v 69 11 bacteria bacteria NNS cord-355239-fc52dn3v 69 12 possess possess VBP cord-355239-fc52dn3v 69 13 various various JJ cord-355239-fc52dn3v 69 14 adhesion adhesion NN cord-355239-fc52dn3v 69 15 molecules molecule NNS cord-355239-fc52dn3v 69 16 such such JJ cord-355239-fc52dn3v 69 17 as as IN cord-355239-fc52dn3v 69 18 a a DT cord-355239-fc52dn3v 69 19 variety variety NN cord-355239-fc52dn3v 69 20 of of IN cord-355239-fc52dn3v 69 21 bacterial bacterial JJ cord-355239-fc52dn3v 69 22 fimbriae fimbriae NN cord-355239-fc52dn3v 69 23 . . . cord-355239-fc52dn3v 70 1 At at IN cord-355239-fc52dn3v 70 2 the the DT cord-355239-fc52dn3v 70 3 initial initial JJ cord-355239-fc52dn3v 70 4 infection infection NN cord-355239-fc52dn3v 70 5 step step NN cord-355239-fc52dn3v 70 6 , , , cord-355239-fc52dn3v 70 7 bacterial bacterial JJ cord-355239-fc52dn3v 70 8 attachment attachment NN cord-355239-fc52dn3v 70 9 is be VBZ cord-355239-fc52dn3v 70 10 mainly mainly RB cord-355239-fc52dn3v 70 11 controlled control VBN cord-355239-fc52dn3v 70 12 by by IN cord-355239-fc52dn3v 70 13 these these DT cord-355239-fc52dn3v 70 14 bacterial bacterial JJ cord-355239-fc52dn3v 70 15 fimbriae fimbriae NN cord-355239-fc52dn3v 70 16 . . . cord-355239-fc52dn3v 71 1 Individual individual JJ cord-355239-fc52dn3v 71 2 fimbria fimbria FW cord-355239-fc52dn3v 71 3 recognize recognize VB cord-355239-fc52dn3v 71 4 and and CC cord-355239-fc52dn3v 71 5 bind bind VB cord-355239-fc52dn3v 71 6 to to IN cord-355239-fc52dn3v 71 7 specific specific JJ cord-355239-fc52dn3v 71 8 receptors receptor NNS cord-355239-fc52dn3v 71 9 to to TO cord-355239-fc52dn3v 71 10 promote promote VB cord-355239-fc52dn3v 71 11 adhesion adhesion NN cord-355239-fc52dn3v 71 12 to to IN cord-355239-fc52dn3v 71 13 the the DT cord-355239-fc52dn3v 71 14 host host NN cord-355239-fc52dn3v 71 15 cell cell NN cord-355239-fc52dn3v 71 16 surface surface NN cord-355239-fc52dn3v 71 17 [ [ -LRB- cord-355239-fc52dn3v 71 18 2 2 CD cord-355239-fc52dn3v 71 19 , , , cord-355239-fc52dn3v 71 20 12 12 CD cord-355239-fc52dn3v 71 21 ] ] -RRB- cord-355239-fc52dn3v 71 22 . . . cord-355239-fc52dn3v 72 1 Long long JJ cord-355239-fc52dn3v 72 2 polar polar JJ cord-355239-fc52dn3v 72 3 fimbriae fimbriae NN cord-355239-fc52dn3v 72 4 ( ( -LRB- cord-355239-fc52dn3v 72 5 LPF LPF NNP cord-355239-fc52dn3v 72 6 ) ) -RRB- cord-355239-fc52dn3v 72 7 and and CC cord-355239-fc52dn3v 72 8 plasmid plasmid NN cord-355239-fc52dn3v 72 9 - - HYPH cord-355239-fc52dn3v 72 10 code code NN cord-355239-fc52dn3v 72 11 fimbriae fimbriae NN cord-355239-fc52dn3v 73 1 ( ( -LRB- cord-355239-fc52dn3v 73 2 PEF PEF NNP cord-355239-fc52dn3v 73 3 ) ) -RRB- cord-355239-fc52dn3v 73 4 are be VBP cord-355239-fc52dn3v 73 5 categorized categorize VBN cord-355239-fc52dn3v 73 6 as as IN cord-355239-fc52dn3v 73 7 type type NN cord-355239-fc52dn3v 73 8 4 4 CD cord-355239-fc52dn3v 73 9 fimbriae fimbriae NN cord-355239-fc52dn3v 73 10 ( ( -LRB- cord-355239-fc52dn3v 73 11 Fig Fig NNP cord-355239-fc52dn3v 73 12 . . NNP cord-355239-fc52dn3v 73 13 2 2 CD cord-355239-fc52dn3v 73 14 ) ) -RRB- cord-355239-fc52dn3v 73 15 . . . cord-355239-fc52dn3v 74 1 Std Std NNP cord-355239-fc52dn3v 74 2 fimbriae fimbriae NN cord-355239-fc52dn3v 74 3 are be VBP cord-355239-fc52dn3v 74 4 categorized categorize VBN cord-355239-fc52dn3v 74 5 as as IN cord-355239-fc52dn3v 74 6 π π NN cord-355239-fc52dn3v 74 7 - - HYPH cord-355239-fc52dn3v 74 8 fimbriae fimbriae NN cord-355239-fc52dn3v 74 9 [ [ -LRB- cord-355239-fc52dn3v 74 10 2 2 CD cord-355239-fc52dn3v 74 11 , , , cord-355239-fc52dn3v 74 12 [ [ -LRB- cord-355239-fc52dn3v 74 13 13 13 CD cord-355239-fc52dn3v 74 14 ] ] -RRB- cord-355239-fc52dn3v 74 15 [ [ -LRB- cord-355239-fc52dn3v 74 16 14 14 CD cord-355239-fc52dn3v 74 17 ] ] -RRB- cord-355239-fc52dn3v 74 18 [ [ -LRB- cord-355239-fc52dn3v 74 19 15 15 CD cord-355239-fc52dn3v 74 20 ] ] -RRB- cord-355239-fc52dn3v 74 21 . . . cord-355239-fc52dn3v 75 1 A a DT cord-355239-fc52dn3v 75 2 previous previous JJ cord-355239-fc52dn3v 75 3 report report NN cord-355239-fc52dn3v 75 4 showed show VBD cord-355239-fc52dn3v 75 5 that that IN cord-355239-fc52dn3v 75 6 when when WRB cord-355239-fc52dn3v 75 7 one one CD cord-355239-fc52dn3v 75 8 of of IN cord-355239-fc52dn3v 75 9 the the DT cord-355239-fc52dn3v 75 10 fimbriae fimbriae NN cord-355239-fc52dn3v 75 11 carried carry VBN cord-355239-fc52dn3v 75 12 by by IN cord-355239-fc52dn3v 75 13 Salmonella Salmonella NNP cord-355239-fc52dn3v 75 14 typhimurium typhimurium NNP cord-355239-fc52dn3v 75 15 was be VBD cord-355239-fc52dn3v 75 16 deleted delete VBN cord-355239-fc52dn3v 75 17 , , , cord-355239-fc52dn3v 75 18 only only RB cord-355239-fc52dn3v 75 19 virulence virulence NN cord-355239-fc52dn3v 75 20 for for IN cord-355239-fc52dn3v 75 21 mouse mouse NN cord-355239-fc52dn3v 75 22 was be VBD cord-355239-fc52dn3v 75 23 moderately moderately RB cord-355239-fc52dn3v 75 24 altered alter VBN cord-355239-fc52dn3v 75 25 , , , cord-355239-fc52dn3v 75 26 and and CC cord-355239-fc52dn3v 75 27 that that IN cord-355239-fc52dn3v 75 28 multiple multiple JJ cord-355239-fc52dn3v 75 29 fimbrial fimbrial JJ cord-355239-fc52dn3v 75 30 adhesins adhesin NNS cord-355239-fc52dn3v 75 31 were be VBD cord-355239-fc52dn3v 75 32 required require VBN cord-355239-fc52dn3v 75 33 for for IN cord-355239-fc52dn3v 75 34 full full JJ cord-355239-fc52dn3v 75 35 virulence virulence NN cord-355239-fc52dn3v 75 36 [ [ -LRB- cord-355239-fc52dn3v 75 37 16 16 CD cord-355239-fc52dn3v 75 38 ] ] -RRB- cord-355239-fc52dn3v 75 39 . . . cord-355239-fc52dn3v 76 1 For for IN cord-355239-fc52dn3v 76 2 Salmonella salmonella NN cord-355239-fc52dn3v 76 3 and and CC cord-355239-fc52dn3v 76 4 assortative assortative NN cord-355239-fc52dn3v 76 5 bacteria bacteria NNS cord-355239-fc52dn3v 76 6 , , , cord-355239-fc52dn3v 76 7 type type NN cord-355239-fc52dn3v 76 8 1 1 CD cord-355239-fc52dn3v 76 9 fimbria fimbria NN cord-355239-fc52dn3v 76 10 is be VBZ cord-355239-fc52dn3v 76 11 the the DT cord-355239-fc52dn3v 76 12 Std Std NNP cord-355239-fc52dn3v 76 13 fimbriae fimbriae NN cord-355239-fc52dn3v 76 14 are be VBP cord-355239-fc52dn3v 76 15 categorized categorize VBN cord-355239-fc52dn3v 76 16 as as IN cord-355239-fc52dn3v 76 17 π π NN cord-355239-fc52dn3v 76 18 - - HYPH cord-355239-fc52dn3v 76 19 fimbriae fimbriae NN cord-355239-fc52dn3v 76 20 . . . cord-355239-fc52dn3v 77 1 Bacterial bacterial JJ cord-355239-fc52dn3v 77 2 flagella flagellum NNS cord-355239-fc52dn3v 77 3 are be VBP cord-355239-fc52dn3v 77 4 the the DT cord-355239-fc52dn3v 77 5 moving move VBG cord-355239-fc52dn3v 77 6 apparatus apparatus NN cord-355239-fc52dn3v 77 7 of of IN cord-355239-fc52dn3v 77 8 bacteria bacteria NNS cord-355239-fc52dn3v 77 9 , , , cord-355239-fc52dn3v 77 10 but but CC cord-355239-fc52dn3v 77 11 their -PRON- PRP$ cord-355239-fc52dn3v 77 12 components component NNS cord-355239-fc52dn3v 77 13 can can MD cord-355239-fc52dn3v 77 14 also also RB cord-355239-fc52dn3v 77 15 contribute contribute VB cord-355239-fc52dn3v 77 16 to to IN cord-355239-fc52dn3v 77 17 the the DT cord-355239-fc52dn3v 77 18 binding binding NN cord-355239-fc52dn3v 77 19 to to IN cord-355239-fc52dn3v 77 20 sugar sugar NN cord-355239-fc52dn3v 77 21 - - HYPH cord-355239-fc52dn3v 77 22 containing contain VBG cord-355239-fc52dn3v 77 23 molecules molecule NNS cord-355239-fc52dn3v 77 24 . . . cord-355239-fc52dn3v 78 1 K. K. NNP cord-355239-fc52dn3v 78 2 Kato Kato NNP cord-355239-fc52dn3v 78 3 et et NNP cord-355239-fc52dn3v 78 4 al al NNP cord-355239-fc52dn3v 78 5 . . . cord-355239-fc52dn3v 79 1 43 43 CD cord-355239-fc52dn3v 79 2 best well RBS cord-355239-fc52dn3v 79 3 characterized characterize VBN cord-355239-fc52dn3v 79 4 [ [ -LRB- cord-355239-fc52dn3v 79 5 17 17 CD cord-355239-fc52dn3v 79 6 ] ] -RRB- cord-355239-fc52dn3v 79 7 . . . cord-355239-fc52dn3v 80 1 Type type NN cord-355239-fc52dn3v 80 2 1 1 CD cord-355239-fc52dn3v 80 3 fimbriae fimbriae NN cord-355239-fc52dn3v 80 4 consist consist VBP cord-355239-fc52dn3v 80 5 of of IN cord-355239-fc52dn3v 80 6 a a DT cord-355239-fc52dn3v 80 7 major major JJ cord-355239-fc52dn3v 80 8 component component NN cord-355239-fc52dn3v 80 9 ( ( -LRB- cord-355239-fc52dn3v 80 10 FimA FimA NNP cord-355239-fc52dn3v 80 11 ) ) -RRB- cord-355239-fc52dn3v 80 12 and and CC cord-355239-fc52dn3v 80 13 a a DT cord-355239-fc52dn3v 80 14 minor minor JJ cord-355239-fc52dn3v 80 15 component component NN cord-355239-fc52dn3v 80 16 ( ( -LRB- cord-355239-fc52dn3v 80 17 FimH FimH NNP cord-355239-fc52dn3v 80 18 ) ) -RRB- cord-355239-fc52dn3v 81 1 ( ( -LRB- cord-355239-fc52dn3v 81 2 Fig Fig NNP cord-355239-fc52dn3v 81 3 . . NNP cord-355239-fc52dn3v 81 4 2 2 CD cord-355239-fc52dn3v 81 5 ) ) -RRB- cord-355239-fc52dn3v 81 6 . . . cord-355239-fc52dn3v 82 1 FimH FimH NNP cord-355239-fc52dn3v 82 2 lies lie VBZ cord-355239-fc52dn3v 82 3 at at IN cord-355239-fc52dn3v 82 4 the the DT cord-355239-fc52dn3v 82 5 tip tip NN cord-355239-fc52dn3v 82 6 of of IN cord-355239-fc52dn3v 82 7 type type NN cord-355239-fc52dn3v 82 8 1 1 CD cord-355239-fc52dn3v 82 9 fimbriae fimbriae NN cord-355239-fc52dn3v 82 10 , , , cord-355239-fc52dn3v 82 11 where where WRB cord-355239-fc52dn3v 82 12 it -PRON- PRP cord-355239-fc52dn3v 82 13 mediates mediate VBZ cord-355239-fc52dn3v 82 14 binding bind VBG cord-355239-fc52dn3v 82 15 to to IN cord-355239-fc52dn3v 82 16 D d NN cord-355239-fc52dn3v 82 17 - - HYPH cord-355239-fc52dn3v 82 18 mannose mannose NN cord-355239-fc52dn3v 82 19 - - HYPH cord-355239-fc52dn3v 82 20 containing contain VBG cord-355239-fc52dn3v 82 21 structures structure NNS cord-355239-fc52dn3v 82 22 and and CC cord-355239-fc52dn3v 82 23 enables enable VBZ cord-355239-fc52dn3v 82 24 the the DT cord-355239-fc52dn3v 82 25 bacteria bacteria NNS cord-355239-fc52dn3v 82 26 to to TO cord-355239-fc52dn3v 82 27 colonize colonize VB cord-355239-fc52dn3v 82 28 various various JJ cord-355239-fc52dn3v 82 29 host host NN cord-355239-fc52dn3v 82 30 tissues tissue NNS cord-355239-fc52dn3v 82 31 [ [ -LRB- cord-355239-fc52dn3v 82 32 18 18 CD cord-355239-fc52dn3v 82 33 ] ] -RRB- cord-355239-fc52dn3v 82 34 . . . cord-355239-fc52dn3v 83 1 Type type NN cord-355239-fc52dn3v 83 2 1 1 CD cord-355239-fc52dn3v 83 3 fimbriae fimbriae NN cord-355239-fc52dn3v 83 4 are be VBP cord-355239-fc52dn3v 83 5 also also RB cord-355239-fc52dn3v 83 6 produced produce VBN cord-355239-fc52dn3v 83 7 by by IN cord-355239-fc52dn3v 83 8 other other JJ cord-355239-fc52dn3v 83 9 gram gram NN cord-355239-fc52dn3v 83 10 - - HYPH cord-355239-fc52dn3v 83 11 negative negative JJ cord-355239-fc52dn3v 83 12 bacteria bacteria NNS cord-355239-fc52dn3v 83 13 , , , cord-355239-fc52dn3v 83 14 such such JJ cord-355239-fc52dn3v 83 15 as as IN cord-355239-fc52dn3v 83 16 Escherichia Escherichia NNP cord-355239-fc52dn3v 83 17 coli coli NNS cord-355239-fc52dn3v 83 18 and and CC cord-355239-fc52dn3v 83 19 Klebsiella Klebsiella NNP cord-355239-fc52dn3v 83 20 pneumoniae pneumoniae NNS cord-355239-fc52dn3v 83 21 [ [ -LRB- cord-355239-fc52dn3v 83 22 19 19 CD cord-355239-fc52dn3v 83 23 ] ] -RRB- cord-355239-fc52dn3v 83 24 . . . cord-355239-fc52dn3v 84 1 The the DT cord-355239-fc52dn3v 84 2 FimH FimH NNP cord-355239-fc52dn3v 84 3 protein protein NN cord-355239-fc52dn3v 84 4 of of IN cord-355239-fc52dn3v 84 5 enterobacterial enterobacterial JJ cord-355239-fc52dn3v 84 6 species specie NNS cord-355239-fc52dn3v 84 7 including include VBG cord-355239-fc52dn3v 84 8 Salmonella Salmonella NNP cord-355239-fc52dn3v 84 9 recognizes recognize VBZ cord-355239-fc52dn3v 84 10 mannose mannose NN cord-355239-fc52dn3v 84 11 - - HYPH cord-355239-fc52dn3v 84 12 containing contain VBG cord-355239-fc52dn3v 84 13 oligosaccharides oligosaccharide NNS cord-355239-fc52dn3v 84 14 [ [ -LRB- cord-355239-fc52dn3v 84 15 18 18 CD cord-355239-fc52dn3v 84 16 ] ] -RRB- cord-355239-fc52dn3v 84 17 . . . cord-355239-fc52dn3v 85 1 In in IN cord-355239-fc52dn3v 85 2 the the DT cord-355239-fc52dn3v 85 3 case case NN cord-355239-fc52dn3v 85 4 of of IN cord-355239-fc52dn3v 85 5 E. E. NNP cord-355239-fc52dn3v 85 6 coli coli NNS cord-355239-fc52dn3v 85 7 , , , cord-355239-fc52dn3v 85 8 previous previous JJ cord-355239-fc52dn3v 85 9 reports report NNS cord-355239-fc52dn3v 85 10 have have VBP cord-355239-fc52dn3v 85 11 shown show VBN cord-355239-fc52dn3v 85 12 that that IN cord-355239-fc52dn3v 85 13 FimH FimH NNP cord-355239-fc52dn3v 85 14 protein protein NN cord-355239-fc52dn3v 85 15 has have VBZ cord-355239-fc52dn3v 85 16 a a DT cord-355239-fc52dn3v 85 17 considerably considerably RB cord-355239-fc52dn3v 85 18 high high JJ cord-355239-fc52dn3v 85 19 affinity affinity NN cord-355239-fc52dn3v 85 20 for for IN cord-355239-fc52dn3v 85 21 oligosaccharides oligosaccharide NNS cord-355239-fc52dn3v 85 22 containing contain VBG cord-355239-fc52dn3v 85 23 Manα1 Manα1 NNP cord-355239-fc52dn3v 85 24 - - HYPH cord-355239-fc52dn3v 85 25 3 3 CD cord-355239-fc52dn3v 85 26 , , , cord-355239-fc52dn3v 85 27 such such JJ cord-355239-fc52dn3v 85 28 as as IN cord-355239-fc52dn3v 85 29 Manα1 Manα1 NNP cord-355239-fc52dn3v 85 30 - - HYPH cord-355239-fc52dn3v 85 31 3Manβ1 3manβ1 CD cord-355239-fc52dn3v 85 32 - - HYPH cord-355239-fc52dn3v 85 33 4GlcNAc 4glcnac CD cord-355239-fc52dn3v 85 34 and and CC cord-355239-fc52dn3v 85 35 Manα1 Manα1 NNP cord-355239-fc52dn3v 85 36 - - HYPH cord-355239-fc52dn3v 85 37 6(Manα1 6(manα1 CD cord-355239-fc52dn3v 85 38 - - HYPH cord-355239-fc52dn3v 85 39 3)Manα1 3)manα1 CD cord-355239-fc52dn3v 85 40 - - HYPH cord-355239-fc52dn3v 85 41 6(Manα1 6(manα1 CD cord-355239-fc52dn3v 85 42 - - HYPH cord-355239-fc52dn3v 85 43 4)Man 4)man CD cord-355239-fc52dn3v 85 44 , , , cord-355239-fc52dn3v 85 45 which which WDT cord-355239-fc52dn3v 85 46 are be VBP cord-355239-fc52dn3v 85 47 constituents constituent NNS cord-355239-fc52dn3v 85 48 of of IN cord-355239-fc52dn3v 85 49 cell cell NN cord-355239-fc52dn3v 85 50 surface surface NN cord-355239-fc52dn3v 85 51 glycoproteins glycoprotein NNS cord-355239-fc52dn3v 85 52 [ [ -LRB- cord-355239-fc52dn3v 85 53 19 19 CD cord-355239-fc52dn3v 85 54 ] ] -RRB- cord-355239-fc52dn3v 85 55 . . . cord-355239-fc52dn3v 86 1 The the DT cord-355239-fc52dn3v 86 2 process process NN cord-355239-fc52dn3v 86 3 of of IN cord-355239-fc52dn3v 86 4 bacterial bacterial JJ cord-355239-fc52dn3v 86 5 adhesion adhesion NN cord-355239-fc52dn3v 86 6 to to IN cord-355239-fc52dn3v 86 7 the the DT cord-355239-fc52dn3v 86 8 epithelial epithelial JJ cord-355239-fc52dn3v 86 9 cell cell NN cord-355239-fc52dn3v 86 10 surface surface NN cord-355239-fc52dn3v 86 11 mediated mediate VBN cord-355239-fc52dn3v 86 12 by by IN cord-355239-fc52dn3v 86 13 Type type NN cord-355239-fc52dn3v 86 14 1 1 CD cord-355239-fc52dn3v 86 15 fimbriae fimbriae NN cord-355239-fc52dn3v 86 16 ( ( -LRB- cord-355239-fc52dn3v 86 17 FimH FimH NNP cord-355239-fc52dn3v 86 18 ) ) -RRB- cord-355239-fc52dn3v 86 19 is be VBZ cord-355239-fc52dn3v 86 20 conservative conservative JJ cord-355239-fc52dn3v 86 21 among among IN cord-355239-fc52dn3v 86 22 enterobacteria enterobacteria NNP cord-355239-fc52dn3v 86 23 . . . cord-355239-fc52dn3v 87 1 Type type NN cord-355239-fc52dn3v 87 2 1 1 CD cord-355239-fc52dn3v 87 3 fimbriae fimbriae NN cord-355239-fc52dn3v 87 4 are be VBP cord-355239-fc52dn3v 87 5 highly highly RB cord-355239-fc52dn3v 87 6 expressed express VBN cord-355239-fc52dn3v 87 7 on on IN cord-355239-fc52dn3v 87 8 the the DT cord-355239-fc52dn3v 87 9 bacterial bacterial JJ cord-355239-fc52dn3v 87 10 surface surface NN cord-355239-fc52dn3v 87 11 , , , cord-355239-fc52dn3v 87 12 allowing allow VBG cord-355239-fc52dn3v 87 13 large large JJ cord-355239-fc52dn3v 87 14 quantities quantity NNS cord-355239-fc52dn3v 87 15 of of IN cord-355239-fc52dn3v 87 16 bacteria bacteria NNS cord-355239-fc52dn3v 87 17 to to TO cord-355239-fc52dn3v 87 18 adhere adhere VB cord-355239-fc52dn3v 87 19 via via IN cord-355239-fc52dn3v 87 20 the the DT cord-355239-fc52dn3v 87 21 FimH FimH NNP cord-355239-fc52dn3v 87 22 - - HYPH cord-355239-fc52dn3v 87 23 Mannose mannose NN cord-355239-fc52dn3v 87 24 interaction interaction NN cord-355239-fc52dn3v 87 25 ( ( -LRB- cord-355239-fc52dn3v 87 26 Fig Fig NNP cord-355239-fc52dn3v 87 27 . . . cord-355239-fc52dn3v 87 28 3 3 CD cord-355239-fc52dn3v 87 29 ) ) -RRB- cord-355239-fc52dn3v 87 30 . . . cord-355239-fc52dn3v 88 1 Type type NN cord-355239-fc52dn3v 88 2 4 4 CD cord-355239-fc52dn3v 88 3 fimbriae fimbriae NN cord-355239-fc52dn3v 88 4 are be VBP cord-355239-fc52dn3v 88 5 thin thin JJ cord-355239-fc52dn3v 88 6 and and CC cord-355239-fc52dn3v 88 7 flexible flexible JJ cord-355239-fc52dn3v 88 8 , , , cord-355239-fc52dn3v 88 9 and and CC cord-355239-fc52dn3v 88 10 generally generally RB cord-355239-fc52dn3v 88 11 expressed express VBN cord-355239-fc52dn3v 88 12 at at IN cord-355239-fc52dn3v 88 13 a a DT cord-355239-fc52dn3v 88 14 lower low JJR cord-355239-fc52dn3v 88 15 level level NN cord-355239-fc52dn3v 88 16 than than IN cord-355239-fc52dn3v 88 17 type type NN cord-355239-fc52dn3v 88 18 1 1 CD cord-355239-fc52dn3v 88 19 fimbriae fimbriae NN cord-355239-fc52dn3v 88 20 . . . cord-355239-fc52dn3v 89 1 Some some DT cord-355239-fc52dn3v 89 2 type type NN cord-355239-fc52dn3v 89 3 4 4 CD cord-355239-fc52dn3v 89 4 fimbriae fimbriae NN cord-355239-fc52dn3v 89 5 are be VBP cord-355239-fc52dn3v 89 6 only only RB cord-355239-fc52dn3v 89 7 present present JJ cord-355239-fc52dn3v 89 8 at at IN cord-355239-fc52dn3v 89 9 low low JJ cord-355239-fc52dn3v 89 10 levels level NNS cord-355239-fc52dn3v 89 11 on on IN cord-355239-fc52dn3v 89 12 the the DT cord-355239-fc52dn3v 89 13 surface surface NN cord-355239-fc52dn3v 89 14 of of IN cord-355239-fc52dn3v 89 15 bacteria bacteria NNS cord-355239-fc52dn3v 89 16 , , , cord-355239-fc52dn3v 89 17 and and CC cord-355239-fc52dn3v 89 18 are be VBP cord-355239-fc52dn3v 89 19 localized localize VBN cord-355239-fc52dn3v 89 20 at at IN cord-355239-fc52dn3v 89 21 the the DT cord-355239-fc52dn3v 89 22 bacterial bacterial JJ cord-355239-fc52dn3v 89 23 pole pole NN cord-355239-fc52dn3v 89 24 . . . cord-355239-fc52dn3v 90 1 Although although IN cord-355239-fc52dn3v 90 2 their -PRON- PRP$ cord-355239-fc52dn3v 90 3 expression expression NN cord-355239-fc52dn3v 90 4 level level NN cord-355239-fc52dn3v 90 5 is be VBZ cord-355239-fc52dn3v 90 6 low low JJ cord-355239-fc52dn3v 90 7 , , , cord-355239-fc52dn3v 90 8 type type NN cord-355239-fc52dn3v 90 9 4 4 CD cord-355239-fc52dn3v 90 10 fimbriae fimbriae NN cord-355239-fc52dn3v 90 11 frequently frequently RB cord-355239-fc52dn3v 90 12 play play VBP cord-355239-fc52dn3v 90 13 an an DT cord-355239-fc52dn3v 90 14 important important JJ cord-355239-fc52dn3v 90 15 role role NN cord-355239-fc52dn3v 90 16 in in IN cord-355239-fc52dn3v 90 17 bacterial bacterial JJ cord-355239-fc52dn3v 90 18 infection infection NN cord-355239-fc52dn3v 90 19 . . . cord-355239-fc52dn3v 91 1 Like like IN cord-355239-fc52dn3v 91 2 type type NN cord-355239-fc52dn3v 91 3 1 1 CD cord-355239-fc52dn3v 91 4 fimbriae fimbriae NN cord-355239-fc52dn3v 91 5 , , , cord-355239-fc52dn3v 91 6 type type NN cord-355239-fc52dn3v 91 7 4 4 CD cord-355239-fc52dn3v 91 8 fimbriae fimbriae NN cord-355239-fc52dn3v 91 9 are be VBP cord-355239-fc52dn3v 91 10 thought think VBN cord-355239-fc52dn3v 91 11 to to TO cord-355239-fc52dn3v 91 12 recognize recognize VB cord-355239-fc52dn3v 91 13 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 91 14 as as IN cord-355239-fc52dn3v 91 15 specific specific JJ cord-355239-fc52dn3v 91 16 receptors receptor NNS cord-355239-fc52dn3v 91 17 , , , cord-355239-fc52dn3v 91 18 but but CC cord-355239-fc52dn3v 91 19 the the DT cord-355239-fc52dn3v 91 20 receptor receptor NN cord-355239-fc52dn3v 91 21 molecules molecule NNS cord-355239-fc52dn3v 91 22 and and CC cord-355239-fc52dn3v 91 23 precise precise JJ cord-355239-fc52dn3v 91 24 functions function NNS cord-355239-fc52dn3v 91 25 of of IN cord-355239-fc52dn3v 91 26 some some DT cord-355239-fc52dn3v 91 27 type type NN cord-355239-fc52dn3v 91 28 4 4 CD cord-355239-fc52dn3v 91 29 fimbriae fimbriae NN cord-355239-fc52dn3v 91 30 have have VBP cord-355239-fc52dn3v 91 31 yet yet RB cord-355239-fc52dn3v 91 32 to to TO cord-355239-fc52dn3v 91 33 be be VB cord-355239-fc52dn3v 91 34 determined determine VBN cord-355239-fc52dn3v 91 35 . . . cord-355239-fc52dn3v 92 1 For for IN cord-355239-fc52dn3v 92 2 example example NN cord-355239-fc52dn3v 92 3 , , , cord-355239-fc52dn3v 92 4 the the DT cord-355239-fc52dn3v 92 5 function function NN cord-355239-fc52dn3v 92 6 of of IN cord-355239-fc52dn3v 92 7 the the DT cord-355239-fc52dn3v 92 8 type type NN cord-355239-fc52dn3v 92 9 4 4 CD cord-355239-fc52dn3v 92 10 fimbria fimbria NN cord-355239-fc52dn3v 92 11 bundle bundle NN cord-355239-fc52dn3v 92 12 - - HYPH cord-355239-fc52dn3v 92 13 forming form VBG cord-355239-fc52dn3v 92 14 pili pili NNP cord-355239-fc52dn3v 92 15 ( ( -LRB- cord-355239-fc52dn3v 92 16 BFP BFP NNP cord-355239-fc52dn3v 92 17 ) ) -RRB- cord-355239-fc52dn3v 92 18 , , , cord-355239-fc52dn3v 92 19 an an DT cord-355239-fc52dn3v 92 20 important important JJ cord-355239-fc52dn3v 92 21 virulence virulence NN cord-355239-fc52dn3v 92 22 factor factor NN cord-355239-fc52dn3v 92 23 for for IN cord-355239-fc52dn3v 92 24 pathogenic pathogenic JJ cord-355239-fc52dn3v 92 25 E. E. NNP cord-355239-fc52dn3v 92 26 coli coli NNS cord-355239-fc52dn3v 92 27 strains strain NNS cord-355239-fc52dn3v 92 28 , , , cord-355239-fc52dn3v 92 29 is be VBZ cord-355239-fc52dn3v 92 30 not not RB cord-355239-fc52dn3v 92 31 yet yet RB cord-355239-fc52dn3v 92 32 known know VBN cord-355239-fc52dn3v 92 33 ( ( -LRB- cord-355239-fc52dn3v 92 34 Fig fig NN cord-355239-fc52dn3v 92 35 . . NNP cord-355239-fc52dn3v 92 36 2 2 CD cord-355239-fc52dn3v 92 37 ) ) -RRB- cord-355239-fc52dn3v 92 38 . . . cord-355239-fc52dn3v 93 1 BFP BFP NNP cord-355239-fc52dn3v 93 2 may may MD cord-355239-fc52dn3v 93 3 not not RB cord-355239-fc52dn3v 93 4 be be VB cord-355239-fc52dn3v 93 5 involved involve VBN cord-355239-fc52dn3v 93 6 in in IN cord-355239-fc52dn3v 93 7 initial initial JJ cord-355239-fc52dn3v 93 8 adhesion adhesion NN cord-355239-fc52dn3v 93 9 ; ; : cord-355239-fc52dn3v 93 10 rather rather RB cord-355239-fc52dn3v 93 11 , , , cord-355239-fc52dn3v 93 12 it -PRON- PRP cord-355239-fc52dn3v 93 13 may may MD cord-355239-fc52dn3v 93 14 participate participate VB cord-355239-fc52dn3v 93 15 in in IN cord-355239-fc52dn3v 93 16 the the DT cord-355239-fc52dn3v 93 17 formation formation NN cord-355239-fc52dn3v 93 18 of of IN cord-355239-fc52dn3v 93 19 the the DT cord-355239-fc52dn3v 93 20 bacterial bacterial JJ cord-355239-fc52dn3v 93 21 colony colony NN cord-355239-fc52dn3v 93 22 by by IN cord-355239-fc52dn3v 93 23 forming form VBG cord-355239-fc52dn3v 93 24 bundles bundle NNS cord-355239-fc52dn3v 93 25 that that WDT cord-355239-fc52dn3v 93 26 link link VBP cord-355239-fc52dn3v 93 27 one one CD cord-355239-fc52dn3v 93 28 bacterium bacterium NN cord-355239-fc52dn3v 93 29 to to IN cord-355239-fc52dn3v 93 30 another another DT cord-355239-fc52dn3v 93 31 [ [ -LRB- cord-355239-fc52dn3v 93 32 20 20 CD cord-355239-fc52dn3v 93 33 ] ] -RRB- cord-355239-fc52dn3v 93 34 . . . cord-355239-fc52dn3v 94 1 Although although IN cord-355239-fc52dn3v 94 2 the the DT cord-355239-fc52dn3v 94 3 function function NN cord-355239-fc52dn3v 94 4 of of IN cord-355239-fc52dn3v 94 5 and and CC cord-355239-fc52dn3v 94 6 receptors receptor NNS cord-355239-fc52dn3v 94 7 for for IN cord-355239-fc52dn3v 94 8 type type NN cord-355239-fc52dn3v 94 9 4 4 CD cord-355239-fc52dn3v 94 10 fimbriae fimbriae NN cord-355239-fc52dn3v 94 11 remain remain VBP cord-355239-fc52dn3v 94 12 unclear unclear JJ cord-355239-fc52dn3v 94 13 , , , cord-355239-fc52dn3v 94 14 bacterial bacterial JJ cord-355239-fc52dn3v 94 15 virulence virulence NN cord-355239-fc52dn3v 94 16 has have VBZ cord-355239-fc52dn3v 94 17 been be VBN cord-355239-fc52dn3v 94 18 shown show VBN cord-355239-fc52dn3v 94 19 to to TO cord-355239-fc52dn3v 94 20 decrease decrease VB cord-355239-fc52dn3v 94 21 when when WRB cord-355239-fc52dn3v 94 22 type type NN cord-355239-fc52dn3v 94 23 4 4 CD cord-355239-fc52dn3v 94 24 fimbriae fimbriae NN cord-355239-fc52dn3v 94 25 are be VBP cord-355239-fc52dn3v 94 26 deleted delete VBN cord-355239-fc52dn3v 94 27 [ [ -LRB- cord-355239-fc52dn3v 94 28 16 16 CD cord-355239-fc52dn3v 94 29 ] ] -RRB- cord-355239-fc52dn3v 94 30 . . . cord-355239-fc52dn3v 95 1 LPF LPF NNP cord-355239-fc52dn3v 95 2 medi- medi- NNP cord-355239-fc52dn3v 96 1 Salmonella salmonella NN cord-355239-fc52dn3v 96 2 and and CC cord-355239-fc52dn3v 96 3 assortative assortative NN cord-355239-fc52dn3v 96 4 bacteria bacteria NNS cord-355239-fc52dn3v 96 5 express express VBP cord-355239-fc52dn3v 96 6 a a DT cord-355239-fc52dn3v 96 7 variety variety NN cord-355239-fc52dn3v 96 8 of of IN cord-355239-fc52dn3v 96 9 fimbriae fimbriae NN cord-355239-fc52dn3v 96 10 . . . cord-355239-fc52dn3v 97 1 The the DT cord-355239-fc52dn3v 97 2 minor minor JJ cord-355239-fc52dn3v 97 3 component component NN cord-355239-fc52dn3v 97 4 of of IN cord-355239-fc52dn3v 97 5 Type type NN cord-355239-fc52dn3v 97 6 1 1 CD cord-355239-fc52dn3v 97 7 fimbriae fimbriae NN cord-355239-fc52dn3v 97 8 , , , cord-355239-fc52dn3v 97 9 FimH FimH NNP cord-355239-fc52dn3v 97 10 , , , cord-355239-fc52dn3v 97 11 is be VBZ cord-355239-fc52dn3v 97 12 present present JJ cord-355239-fc52dn3v 97 13 at at IN cord-355239-fc52dn3v 97 14 the the DT cord-355239-fc52dn3v 97 15 tip tip NN cord-355239-fc52dn3v 97 16 of of IN cord-355239-fc52dn3v 97 17 type type NN cord-355239-fc52dn3v 97 18 1 1 CD cord-355239-fc52dn3v 97 19 fimbriae fimbriae NN cord-355239-fc52dn3v 97 20 , , , cord-355239-fc52dn3v 97 21 mediates mediate VBZ cord-355239-fc52dn3v 97 22 binding bind VBG cord-355239-fc52dn3v 97 23 to to IN cord-355239-fc52dn3v 97 24 D d NN cord-355239-fc52dn3v 97 25 - - HYPH cord-355239-fc52dn3v 97 26 mannose mannose NN cord-355239-fc52dn3v 97 27 - - HYPH cord-355239-fc52dn3v 97 28 containing contain VBG cord-355239-fc52dn3v 97 29 structures structure NNS cord-355239-fc52dn3v 97 30 and and CC cord-355239-fc52dn3v 97 31 enables enable VBZ cord-355239-fc52dn3v 97 32 bacteria bacteria NNS cord-355239-fc52dn3v 97 33 to to TO cord-355239-fc52dn3v 97 34 colonize colonize VB cord-355239-fc52dn3v 97 35 various various JJ cord-355239-fc52dn3v 97 36 host host NN cord-355239-fc52dn3v 97 37 tissues tissue NNS cord-355239-fc52dn3v 97 38 [ [ -LRB- cord-355239-fc52dn3v 97 39 18 18 CD cord-355239-fc52dn3v 97 40 ] ] -RRB- cord-355239-fc52dn3v 97 41 . . . cord-355239-fc52dn3v 98 1 Type type NN cord-355239-fc52dn3v 98 2 1 1 CD cord-355239-fc52dn3v 98 3 fimbria fimbria NN cord-355239-fc52dn3v 98 4 is be VBZ cord-355239-fc52dn3v 98 5 highly highly RB cord-355239-fc52dn3v 98 6 expressed express VBN cord-355239-fc52dn3v 98 7 on on IN cord-355239-fc52dn3v 98 8 the the DT cord-355239-fc52dn3v 98 9 bacterial bacterial JJ cord-355239-fc52dn3v 98 10 surface surface NN cord-355239-fc52dn3v 98 11 , , , cord-355239-fc52dn3v 98 12 allowing allow VBG cord-355239-fc52dn3v 98 13 large large JJ cord-355239-fc52dn3v 98 14 amounts amount NNS cord-355239-fc52dn3v 98 15 of of IN cord-355239-fc52dn3v 98 16 bacteria bacteria NNS cord-355239-fc52dn3v 98 17 to to TO cord-355239-fc52dn3v 98 18 adhere adhere VB cord-355239-fc52dn3v 98 19 via via IN cord-355239-fc52dn3v 98 20 the the DT cord-355239-fc52dn3v 98 21 FimH FimH NNP cord-355239-fc52dn3v 98 22 - - HYPH cord-355239-fc52dn3v 98 23 mannose mannose NN cord-355239-fc52dn3v 98 24 interaction interaction NN cord-355239-fc52dn3v 98 25 . . . cord-355239-fc52dn3v 99 1 The the DT cord-355239-fc52dn3v 99 2 various various JJ cord-355239-fc52dn3v 99 3 kinds kind NNS cord-355239-fc52dn3v 99 4 of of IN cord-355239-fc52dn3v 99 5 type type NN cord-355239-fc52dn3v 99 6 4 4 CD cord-355239-fc52dn3v 99 7 fimbriae fimbriae NN cord-355239-fc52dn3v 99 8 play play VBP cord-355239-fc52dn3v 99 9 an an DT cord-355239-fc52dn3v 99 10 important important JJ cord-355239-fc52dn3v 99 11 role role NN cord-355239-fc52dn3v 99 12 in in IN cord-355239-fc52dn3v 99 13 bacterial bacterial JJ cord-355239-fc52dn3v 99 14 infection infection NN cord-355239-fc52dn3v 99 15 . . . cord-355239-fc52dn3v 100 1 Plasmid plasmid NN cord-355239-fc52dn3v 100 2 - - HYPH cord-355239-fc52dn3v 100 3 encoded encode VBN cord-355239-fc52dn3v 100 4 fimbria fimbria NNP cord-355239-fc52dn3v 100 5 ( ( -LRB- cord-355239-fc52dn3v 100 6 PEF PEF NNP cord-355239-fc52dn3v 100 7 ) ) -RRB- cord-355239-fc52dn3v 100 8 is be VBZ cord-355239-fc52dn3v 100 9 required require VBN cord-355239-fc52dn3v 100 10 for for IN cord-355239-fc52dn3v 100 11 bacterial bacterial JJ cord-355239-fc52dn3v 100 12 attachment attachment NN cord-355239-fc52dn3v 100 13 to to TO cord-355239-fc52dn3v 100 14 intestinal intestinal JJ cord-355239-fc52dn3v 100 15 epithelial epithelial JJ cord-355239-fc52dn3v 100 16 cells cell NNS cord-355239-fc52dn3v 100 17 . . . cord-355239-fc52dn3v 101 1 PEF PEF NNP cord-355239-fc52dn3v 101 2 specifically specifically RB cord-355239-fc52dn3v 101 3 binds bind VBZ cord-355239-fc52dn3v 101 4 to to IN cord-355239-fc52dn3v 101 5 trisaccharide trisaccharide NN cord-355239-fc52dn3v 101 6 Galβ1 Galβ1 NNS cord-355239-fc52dn3v 101 7 - - HYPH cord-355239-fc52dn3v 101 8 4(Fucα1 4(fucα1 CD cord-355239-fc52dn3v 101 9 - - HYPH cord-355239-fc52dn3v 101 10 3)GlcNAc 3)glcnac NN cord-355239-fc52dn3v 101 11 , , , cord-355239-fc52dn3v 101 12 also also RB cord-355239-fc52dn3v 101 13 known know VBN cord-355239-fc52dn3v 101 14 as as IN cord-355239-fc52dn3v 101 15 the the DT cord-355239-fc52dn3v 101 16 Lewis Lewis NNP cord-355239-fc52dn3v 101 17 X X NNP cord-355239-fc52dn3v 101 18 ( ( -LRB- cord-355239-fc52dn3v 101 19 Le Le NNP cord-355239-fc52dn3v 101 20 X X NNP cord-355239-fc52dn3v 101 21 ) ) -RRB- cord-355239-fc52dn3v 101 22 blood blood NN cord-355239-fc52dn3v 101 23 group group NN cord-355239-fc52dn3v 101 24 antigen antigen NN cord-355239-fc52dn3v 101 25 [ [ -LRB- cord-355239-fc52dn3v 101 26 13 13 CD cord-355239-fc52dn3v 101 27 ] ] -RRB- cord-355239-fc52dn3v 101 28 . . . cord-355239-fc52dn3v 102 1 Long long JJ cord-355239-fc52dn3v 102 2 polar polar JJ cord-355239-fc52dn3v 102 3 fimbria fimbria FW cord-355239-fc52dn3v 102 4 ( ( -LRB- cord-355239-fc52dn3v 102 5 LPF LPF NNP cord-355239-fc52dn3v 102 6 ) ) -RRB- cord-355239-fc52dn3v 102 7 mediates mediate VBZ cord-355239-fc52dn3v 102 8 the the DT cord-355239-fc52dn3v 102 9 adhesion adhesion NN cord-355239-fc52dn3v 102 10 of of IN cord-355239-fc52dn3v 102 11 S. S. NNP cord-355239-fc52dn3v 102 12 typhimurium typhimurium NN cord-355239-fc52dn3v 102 13 to to IN cord-355239-fc52dn3v 102 14 murine murine JJ cord-355239-fc52dn3v 102 15 Peyer Peyer NNP cord-355239-fc52dn3v 102 16 's 's POS cord-355239-fc52dn3v 102 17 patches patch NNS cord-355239-fc52dn3v 102 18 [ [ -LRB- cord-355239-fc52dn3v 102 19 21 21 CD cord-355239-fc52dn3v 102 20 ] ] -RRB- cord-355239-fc52dn3v 102 21 . . . cord-355239-fc52dn3v 103 1 Extracellular Extracellular NNP cord-355239-fc52dn3v 103 2 matrix matrix NN cord-355239-fc52dn3v 103 3 proteins protein NNS cord-355239-fc52dn3v 103 4 ( ( -LRB- cord-355239-fc52dn3v 103 5 ECMs ECMs NNP cord-355239-fc52dn3v 103 6 ) ) -RRB- cord-355239-fc52dn3v 103 7 may may MD cord-355239-fc52dn3v 103 8 act act VB cord-355239-fc52dn3v 103 9 as as IN cord-355239-fc52dn3v 103 10 receptors receptor NNS cord-355239-fc52dn3v 103 11 for for IN cord-355239-fc52dn3v 103 12 LPF LPF NNP cord-355239-fc52dn3v 103 13 . . . cord-355239-fc52dn3v 104 1 ECMs ECMs NNP cord-355239-fc52dn3v 104 2 are be VBP cord-355239-fc52dn3v 104 3 modified modify VBN cord-355239-fc52dn3v 104 4 with with IN cord-355239-fc52dn3v 104 5 various various JJ cord-355239-fc52dn3v 104 6 carbohydrate carbohydrate NN cord-355239-fc52dn3v 104 7 moieties moiety NNS cord-355239-fc52dn3v 104 8 , , , cord-355239-fc52dn3v 104 9 and and CC cord-355239-fc52dn3v 104 10 the the DT cord-355239-fc52dn3v 104 11 presence presence NN cord-355239-fc52dn3v 104 12 of of IN cord-355239-fc52dn3v 104 13 Mannose Mannose NNP cord-355239-fc52dn3v 104 14 inhibits inhibit VBZ cord-355239-fc52dn3v 104 15 the the DT cord-355239-fc52dn3v 104 16 LPF LPF NNP cord-355239-fc52dn3v 104 17 - - HYPH cord-355239-fc52dn3v 104 18 ECM ECM NNP cord-355239-fc52dn3v 104 19 interaction interaction NN cord-355239-fc52dn3v 104 20 . . . cord-355239-fc52dn3v 105 1 Mannose mannose NN cord-355239-fc52dn3v 105 2 - - HYPH cord-355239-fc52dn3v 105 3 containing contain VBG cord-355239-fc52dn3v 105 4 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 105 5 may may MD cord-355239-fc52dn3v 105 6 participate participate VB cord-355239-fc52dn3v 105 7 in in IN cord-355239-fc52dn3v 105 8 bacterial bacterial JJ cord-355239-fc52dn3v 105 9 adhesion adhesion NN cord-355239-fc52dn3v 105 10 via via IN cord-355239-fc52dn3v 105 11 LPF LPF NNP cord-355239-fc52dn3v 105 12 [ [ -LRB- cord-355239-fc52dn3v 105 13 23 23 CD cord-355239-fc52dn3v 105 14 ] ] -RRB- cord-355239-fc52dn3v 105 15 . . . cord-355239-fc52dn3v 106 1 Std Std NNP cord-355239-fc52dn3v 106 2 fimbriae fimbriae NN cord-355239-fc52dn3v 106 3 are be VBP cord-355239-fc52dn3v 106 4 categorized categorize VBN cord-355239-fc52dn3v 106 5 as as IN cord-355239-fc52dn3v 106 6 π π NN cord-355239-fc52dn3v 106 7 - - HYPH cord-355239-fc52dn3v 106 8 fimbriae fimbriae NN cord-355239-fc52dn3v 106 9 and and CC cord-355239-fc52dn3v 106 10 are be VBP cord-355239-fc52dn3v 106 11 well well RB cord-355239-fc52dn3v 106 12 conserved conserve VBN cord-355239-fc52dn3v 106 13 among among IN cord-355239-fc52dn3v 106 14 S. S. NNP cord-355239-fc52dn3v 106 15 enterica enterica NNP cord-355239-fc52dn3v 106 16 serotypes serotype NNS cord-355239-fc52dn3v 106 17 but but CC cord-355239-fc52dn3v 106 18 absent absent JJ cord-355239-fc52dn3v 106 19 from from IN cord-355239-fc52dn3v 106 20 other other JJ cord-355239-fc52dn3v 106 21 related related JJ cord-355239-fc52dn3v 106 22 bacterial bacterial JJ cord-355239-fc52dn3v 106 23 species specie NNS cord-355239-fc52dn3v 106 24 . . . cord-355239-fc52dn3v 107 1 Std Std NNP cord-355239-fc52dn3v 107 2 fimbriae fimbriae NN cord-355239-fc52dn3v 107 3 recognize recognize VB cord-355239-fc52dn3v 107 4 and and CC cord-355239-fc52dn3v 107 5 bind bind VB cord-355239-fc52dn3v 107 6 the the DT cord-355239-fc52dn3v 107 7 H h NN cord-355239-fc52dn3v 107 8 type type NN cord-355239-fc52dn3v 107 9 2 2 CD cord-355239-fc52dn3v 107 10 histo histo JJ cord-355239-fc52dn3v 107 11 - - HYPH cord-355239-fc52dn3v 107 12 blood blood NN cord-355239-fc52dn3v 107 13 group group NN cord-355239-fc52dn3v 107 14 oligosaccharide oligosaccharide NN cord-355239-fc52dn3v 107 15 , , , cord-355239-fc52dn3v 107 16 the the DT cord-355239-fc52dn3v 107 17 terminal terminal JJ cord-355239-fc52dn3v 107 18 Fucα1 Fucα1 NNS cord-355239-fc52dn3v 107 19 - - HYPH cord-355239-fc52dn3v 107 20 2Galβ1 2galβ1 CD cord-355239-fc52dn3v 107 21 moiety moiety NN cord-355239-fc52dn3v 107 22 . . . cord-355239-fc52dn3v 108 1 S. S. NNP cord-355239-fc52dn3v 108 2 typhi typhi NNP cord-355239-fc52dn3v 108 3 and and CC cord-355239-fc52dn3v 108 4 S. S. NNP cord-355239-fc52dn3v 108 5 paratifi paratifi NN cord-355239-fc52dn3v 108 6 can can MD cord-355239-fc52dn3v 108 7 survive survive VB cord-355239-fc52dn3v 108 8 within within IN cord-355239-fc52dn3v 108 9 the the DT cord-355239-fc52dn3v 108 10 macrophages macrophage NNS cord-355239-fc52dn3v 108 11 after after IN cord-355239-fc52dn3v 108 12 they -PRON- PRP cord-355239-fc52dn3v 108 13 are be VBP cord-355239-fc52dn3v 108 14 engulfed engulf VBN cord-355239-fc52dn3v 108 15 by by IN cord-355239-fc52dn3v 108 16 phagocytosis phagocytosis NN cord-355239-fc52dn3v 108 17 . . . cord-355239-fc52dn3v 109 1 Non non JJ cord-355239-fc52dn3v 109 2 - - JJ cord-355239-fc52dn3v 109 3 typhoidal typhoidal JJ cord-355239-fc52dn3v 109 4 Salmonella Salmonella NNP cord-355239-fc52dn3v 109 5 , , , cord-355239-fc52dn3v 109 6 S. S. NNP cord-355239-fc52dn3v 109 7 typhimurium typhimurium NN cord-355239-fc52dn3v 109 8 and and CC cord-355239-fc52dn3v 109 9 S. S. NNP cord-355239-fc52dn3v 109 10 enteritidis enteritidis NN cord-355239-fc52dn3v 109 11 , , , cord-355239-fc52dn3v 109 12 however however RB cord-355239-fc52dn3v 109 13 , , , cord-355239-fc52dn3v 109 14 are be VBP cord-355239-fc52dn3v 109 15 unable unable JJ cord-355239-fc52dn3v 109 16 to to TO cord-355239-fc52dn3v 109 17 survive survive VB cord-355239-fc52dn3v 109 18 within within IN cord-355239-fc52dn3v 109 19 macrophages macrophage NNS cord-355239-fc52dn3v 109 20 . . . cord-355239-fc52dn3v 110 1 ates ates NNP cord-355239-fc52dn3v 110 2 the the DT cord-355239-fc52dn3v 110 3 adhesion adhesion NN cord-355239-fc52dn3v 110 4 of of IN cord-355239-fc52dn3v 110 5 S. S. NNP cord-355239-fc52dn3v 110 6 typhimurium typhimurium NN cord-355239-fc52dn3v 110 7 to to IN cord-355239-fc52dn3v 110 8 murine murine JJ cord-355239-fc52dn3v 110 9 Peyer Peyer NNP cord-355239-fc52dn3v 110 10 's 's POS cord-355239-fc52dn3v 110 11 patches patch NNS cord-355239-fc52dn3v 110 12 [ [ -LRB- cord-355239-fc52dn3v 110 13 21 21 CD cord-355239-fc52dn3v 110 14 ] ] -RRB- cord-355239-fc52dn3v 110 15 . . . cord-355239-fc52dn3v 111 1 LPF LPF NNP cord-355239-fc52dn3v 111 2 was be VBD cord-355239-fc52dn3v 111 3 first first RB cord-355239-fc52dn3v 111 4 described describe VBN cord-355239-fc52dn3v 111 5 in in IN cord-355239-fc52dn3v 111 6 S. S. NNP cord-355239-fc52dn3v 111 7 typhimurium typhimurium NN cord-355239-fc52dn3v 111 8 , , , cord-355239-fc52dn3v 111 9 and and CC cord-355239-fc52dn3v 111 10 is be VBZ cord-355239-fc52dn3v 111 11 found find VBN cord-355239-fc52dn3v 111 12 in in IN cord-355239-fc52dn3v 111 13 numerous numerous JJ cord-355239-fc52dn3v 111 14 pathogenic pathogenic JJ cord-355239-fc52dn3v 111 15 E. E. NNP cord-355239-fc52dn3v 111 16 coli coli NNS cord-355239-fc52dn3v 111 17 strains strain NNS cord-355239-fc52dn3v 111 18 [ [ -LRB- cord-355239-fc52dn3v 111 19 22 22 CD cord-355239-fc52dn3v 111 20 ] ] -RRB- cord-355239-fc52dn3v 111 21 . . . cord-355239-fc52dn3v 112 1 Although although IN cord-355239-fc52dn3v 112 2 its -PRON- PRP$ cord-355239-fc52dn3v 112 3 specific specific JJ cord-355239-fc52dn3v 112 4 receptor receptor NN cord-355239-fc52dn3v 112 5 remains remain VBZ cord-355239-fc52dn3v 112 6 unclear unclear JJ cord-355239-fc52dn3v 112 7 , , , cord-355239-fc52dn3v 112 8 extracellular extracellular JJ cord-355239-fc52dn3v 112 9 matrix matrix NN cord-355239-fc52dn3v 112 10 proteins protein NNS cord-355239-fc52dn3v 112 11 ( ( -LRB- cord-355239-fc52dn3v 112 12 ECMs ECMs NNP cord-355239-fc52dn3v 112 13 ) ) -RRB- cord-355239-fc52dn3v 112 14 , , , cord-355239-fc52dn3v 112 15 which which WDT cord-355239-fc52dn3v 112 16 comprise comprise VBP cord-355239-fc52dn3v 112 17 an an DT cord-355239-fc52dn3v 112 18 interlocking interlock VBG cord-355239-fc52dn3v 112 19 mesh mesh NN cord-355239-fc52dn3v 112 20 of of IN cord-355239-fc52dn3v 112 21 fibrous fibrous JJ cord-355239-fc52dn3v 112 22 proteins protein NNS cord-355239-fc52dn3v 112 23 and and CC cord-355239-fc52dn3v 112 24 glycosaminoglycans glycosaminoglycan NNS cord-355239-fc52dn3v 112 25 , , , cord-355239-fc52dn3v 112 26 may may MD cord-355239-fc52dn3v 112 27 act act VB cord-355239-fc52dn3v 112 28 as as IN cord-355239-fc52dn3v 112 29 a a DT cord-355239-fc52dn3v 112 30 receptor receptor NN cord-355239-fc52dn3v 112 31 for for IN cord-355239-fc52dn3v 112 32 LPF LPF NNP cord-355239-fc52dn3v 112 33 of of IN cord-355239-fc52dn3v 112 34 enterohemorrhagic enterohemorrhagic NNP cord-355239-fc52dn3v 112 35 E. E. NNP cord-355239-fc52dn3v 112 36 coli coli NNS cord-355239-fc52dn3v 113 1 O157 O157 NNP cord-355239-fc52dn3v 113 2 : : : cord-355239-fc52dn3v 114 1 H7 H7 NNP cord-355239-fc52dn3v 114 2 ( ( -LRB- cord-355239-fc52dn3v 114 3 Fig Fig NNP cord-355239-fc52dn3v 114 4 . . . cord-355239-fc52dn3v 114 5 3 3 CD cord-355239-fc52dn3v 114 6 ) ) -RRB- cord-355239-fc52dn3v 114 7 . . . cord-355239-fc52dn3v 115 1 ECMs ECMs NNP cord-355239-fc52dn3v 115 2 are be VBP cord-355239-fc52dn3v 115 3 modified modify VBN cord-355239-fc52dn3v 115 4 by by IN cord-355239-fc52dn3v 115 5 various various JJ cord-355239-fc52dn3v 115 6 carbohydrate carbohydrate NN cord-355239-fc52dn3v 115 7 moieties moiety NNS cord-355239-fc52dn3v 115 8 , , , cord-355239-fc52dn3v 115 9 and and CC cord-355239-fc52dn3v 115 10 the the DT cord-355239-fc52dn3v 115 11 addition addition NN cord-355239-fc52dn3v 115 12 of of IN cord-355239-fc52dn3v 115 13 mannose mannose NN cord-355239-fc52dn3v 115 14 inhibits inhibit VBZ cord-355239-fc52dn3v 115 15 LPF LPF NNP cord-355239-fc52dn3v 115 16 - - HYPH cord-355239-fc52dn3v 115 17 ECM ECM NNP cord-355239-fc52dn3v 115 18 interaction interaction NN cord-355239-fc52dn3v 115 19 . . . cord-355239-fc52dn3v 116 1 Then then RB cord-355239-fc52dn3v 116 2 mannose mannose NN cord-355239-fc52dn3v 116 3 - - HYPH cord-355239-fc52dn3v 116 4 containing contain VBG cord-355239-fc52dn3v 116 5 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 116 6 may may MD cord-355239-fc52dn3v 116 7 participate participate VB cord-355239-fc52dn3v 116 8 in in IN cord-355239-fc52dn3v 116 9 bacterial bacterial JJ cord-355239-fc52dn3v 116 10 adhesion adhesion NN cord-355239-fc52dn3v 116 11 by by IN cord-355239-fc52dn3v 116 12 LPF LPF NNP cord-355239-fc52dn3v 116 13 [ [ -LRB- cord-355239-fc52dn3v 116 14 23 23 CD cord-355239-fc52dn3v 116 15 ] ] -RRB- cord-355239-fc52dn3v 116 16 . . . cord-355239-fc52dn3v 117 1 In in IN cord-355239-fc52dn3v 117 2 some some DT cord-355239-fc52dn3v 117 3 cases case NNS cord-355239-fc52dn3v 117 4 , , , cord-355239-fc52dn3v 117 5 type type NN cord-355239-fc52dn3v 117 6 4 4 CD cord-355239-fc52dn3v 117 7 fimbriae fimbriae NN cord-355239-fc52dn3v 117 8 are be VBP cord-355239-fc52dn3v 117 9 encoded encode VBN cord-355239-fc52dn3v 117 10 on on IN cord-355239-fc52dn3v 117 11 plasmids plasmid NNS cord-355239-fc52dn3v 117 12 . . . cord-355239-fc52dn3v 118 1 Such such JJ cord-355239-fc52dn3v 118 2 plasmids plasmid NNS cord-355239-fc52dn3v 118 3 frequently frequently RB cord-355239-fc52dn3v 118 4 encode encode VBP cord-355239-fc52dn3v 118 5 virulence virulence NN cord-355239-fc52dn3v 118 6 factors factor NNS cord-355239-fc52dn3v 118 7 for for IN cord-355239-fc52dn3v 118 8 host host NN cord-355239-fc52dn3v 118 9 bacteria bacteria NNS cord-355239-fc52dn3v 118 10 , , , cord-355239-fc52dn3v 118 11 and and CC cord-355239-fc52dn3v 118 12 are be VBP cord-355239-fc52dn3v 118 13 therefore therefore RB cord-355239-fc52dn3v 118 14 called call VBN cord-355239-fc52dn3v 118 15 " " `` cord-355239-fc52dn3v 118 16 virulence virulence NN cord-355239-fc52dn3v 118 17 plasmids plasmid NNS cord-355239-fc52dn3v 118 18 " " '' cord-355239-fc52dn3v 118 19 [ [ -LRB- cord-355239-fc52dn3v 118 20 24 24 CD cord-355239-fc52dn3v 118 21 ] ] -RRB- cord-355239-fc52dn3v 118 22 . . . cord-355239-fc52dn3v 119 1 PEF PEF NNP cord-355239-fc52dn3v 119 2 is be VBZ cord-355239-fc52dn3v 119 3 required require VBN cord-355239-fc52dn3v 119 4 for for IN cord-355239-fc52dn3v 119 5 bacterial bacterial JJ cord-355239-fc52dn3v 119 6 attachment attachment NN cord-355239-fc52dn3v 119 7 to to TO cord-355239-fc52dn3v 119 8 intestinal intestinal JJ cord-355239-fc52dn3v 119 9 epithelial epithelial JJ cord-355239-fc52dn3v 119 10 cells cell NNS cord-355239-fc52dn3v 119 11 . . . cord-355239-fc52dn3v 120 1 It -PRON- PRP cord-355239-fc52dn3v 120 2 specifically specifically RB cord-355239-fc52dn3v 120 3 binds bind VBZ cord-355239-fc52dn3v 120 4 to to IN cord-355239-fc52dn3v 120 5 trisaccharide trisaccharide NN cord-355239-fc52dn3v 120 6 Galβ1 Galβ1 NNS cord-355239-fc52dn3v 120 7 - - HYPH cord-355239-fc52dn3v 120 8 4(Fucα1 4(fucα1 CD cord-355239-fc52dn3v 120 9 - - HYPH cord-355239-fc52dn3v 120 10 3)GlcNAc 3)glcnac NN cord-355239-fc52dn3v 120 11 , , , cord-355239-fc52dn3v 120 12 also also RB cord-355239-fc52dn3v 120 13 known know VBN cord-355239-fc52dn3v 120 14 as as IN cord-355239-fc52dn3v 120 15 the the DT cord-355239-fc52dn3v 120 16 Lewis Lewis NNP cord-355239-fc52dn3v 120 17 X X NNP cord-355239-fc52dn3v 120 18 ( ( -LRB- cord-355239-fc52dn3v 120 19 Le Le NNP cord-355239-fc52dn3v 120 20 X X NNP cord-355239-fc52dn3v 120 21 ) ) -RRB- cord-355239-fc52dn3v 120 22 blood blood NN cord-355239-fc52dn3v 120 23 group group NN cord-355239-fc52dn3v 120 24 antigen antigen NN cord-355239-fc52dn3v 120 25 ( ( -LRB- cord-355239-fc52dn3v 120 26 Fig Fig NNP cord-355239-fc52dn3v 120 27 . . . cord-355239-fc52dn3v 120 28 3 3 LS cord-355239-fc52dn3v 120 29 ) ) -RRB- cord-355239-fc52dn3v 120 30 [ [ -LRB- cord-355239-fc52dn3v 120 31 13 13 CD cord-355239-fc52dn3v 120 32 ] ] -RRB- cord-355239-fc52dn3v 120 33 . . . cord-355239-fc52dn3v 121 1 The the DT cord-355239-fc52dn3v 121 2 Le Le NNP cord-355239-fc52dn3v 121 3 X X NNP cord-355239-fc52dn3v 121 4 antigen antigen NN cord-355239-fc52dn3v 121 5 is be VBZ cord-355239-fc52dn3v 121 6 defined define VBN cord-355239-fc52dn3v 121 7 by by IN cord-355239-fc52dn3v 121 8 the the DT cord-355239-fc52dn3v 121 9 presence presence NN cord-355239-fc52dn3v 121 10 of of IN cord-355239-fc52dn3v 121 11 a a DT cord-355239-fc52dn3v 121 12 terminal terminal JJ cord-355239-fc52dn3v 121 13 Galβ1 Galβ1 NNS cord-355239-fc52dn3v 121 14 - - : cord-355239-fc52dn3v 121 15 4(Fucα-3)GlcNAc 4(fucα-3)glcnac CD cord-355239-fc52dn3v 121 16 moiety moiety NN cord-355239-fc52dn3v 121 17 on on IN cord-355239-fc52dn3v 121 18 saccharide saccharide JJ cord-355239-fc52dn3v 121 19 chains chain NNS cord-355239-fc52dn3v 121 20 of of IN cord-355239-fc52dn3v 121 21 glycoproteins glycoprotein NNS cord-355239-fc52dn3v 121 22 or or CC cord-355239-fc52dn3v 121 23 glycosphingolipids glycosphingolipid NNS cord-355239-fc52dn3v 121 24 ; ; : cord-355239-fc52dn3v 121 25 in in IN cord-355239-fc52dn3v 121 26 the the DT cord-355239-fc52dn3v 121 27 human human JJ cord-355239-fc52dn3v 121 28 intestine intestine NN cord-355239-fc52dn3v 121 29 , , , cord-355239-fc52dn3v 121 30 it -PRON- PRP cord-355239-fc52dn3v 121 31 is be VBZ cord-355239-fc52dn3v 121 32 expressed express VBN cord-355239-fc52dn3v 121 33 mainly mainly RB cord-355239-fc52dn3v 121 34 in in IN cord-355239-fc52dn3v 121 35 crypt crypt JJ cord-355239-fc52dn3v 121 36 epithelial epithelial JJ cord-355239-fc52dn3v 121 37 cells cell NNS cord-355239-fc52dn3v 121 38 [ [ -LRB- cord-355239-fc52dn3v 121 39 25 25 CD cord-355239-fc52dn3v 121 40 ] ] -RRB- cord-355239-fc52dn3v 121 41 . . . cord-355239-fc52dn3v 122 1 S. S. NNP cord-355239-fc52dn3v 122 2 typhimurium typhimurium NNP cord-355239-fc52dn3v 122 3 possesses possess VBZ cord-355239-fc52dn3v 122 4 PEF PEF NNP cord-355239-fc52dn3v 122 5 as as IN cord-355239-fc52dn3v 122 6 an an DT cord-355239-fc52dn3v 122 7 adhesin adhesin NN cord-355239-fc52dn3v 122 8 that that WDT cord-355239-fc52dn3v 122 9 binds bind VBZ cord-355239-fc52dn3v 122 10 to to IN cord-355239-fc52dn3v 122 11 a a DT cord-355239-fc52dn3v 122 12 crypt crypt NN cord-355239-fc52dn3v 122 13 - - HYPH cord-355239-fc52dn3v 122 14 specific specific JJ cord-355239-fc52dn3v 122 15 histo histo JJ cord-355239-fc52dn3v 122 16 - - HYPH cord-355239-fc52dn3v 122 17 blood blood NN cord-355239-fc52dn3v 122 18 group group NN cord-355239-fc52dn3v 122 19 antigen antigen NN cord-355239-fc52dn3v 122 20 that that WDT cord-355239-fc52dn3v 122 21 may may MD cord-355239-fc52dn3v 122 22 be be VB cord-355239-fc52dn3v 122 23 relevant relevant JJ cord-355239-fc52dn3v 122 24 to to IN cord-355239-fc52dn3v 122 25 the the DT cord-355239-fc52dn3v 122 26 pathogenesis pathogenesis NN cord-355239-fc52dn3v 122 27 of of IN cord-355239-fc52dn3v 122 28 human human JJ cord-355239-fc52dn3v 122 29 infections infection NNS cord-355239-fc52dn3v 122 30 . . . cord-355239-fc52dn3v 123 1 Abundant abundant JJ cord-355239-fc52dn3v 123 2 crypt crypt NN cord-355239-fc52dn3v 123 3 abscesses abscess NNS cord-355239-fc52dn3v 123 4 are be VBP cord-355239-fc52dn3v 123 5 commonly commonly RB cord-355239-fc52dn3v 123 6 found find VBN cord-355239-fc52dn3v 123 7 in in IN cord-355239-fc52dn3v 123 8 S. S. NNP cord-355239-fc52dn3v 123 9 typhimurium typhimurium NN cord-355239-fc52dn3v 123 10 patients patient NNS cord-355239-fc52dn3v 123 11 , , , cord-355239-fc52dn3v 123 12 raising raise VBG cord-355239-fc52dn3v 123 13 the the DT cord-355239-fc52dn3v 123 14 possibility possibility NN cord-355239-fc52dn3v 123 15 that that IN cord-355239-fc52dn3v 123 16 the the DT cord-355239-fc52dn3v 123 17 pathogen pathogen NN cord-355239-fc52dn3v 123 18 may may MD cord-355239-fc52dn3v 123 19 bind bind VB cord-355239-fc52dn3v 123 20 to to IN cord-355239-fc52dn3v 123 21 human human JJ cord-355239-fc52dn3v 123 22 crypt crypt NN cord-355239-fc52dn3v 123 23 epithelium epithelium NN cord-355239-fc52dn3v 123 24 at at IN cord-355239-fc52dn3v 123 25 a a DT cord-355239-fc52dn3v 123 26 later later JJ cord-355239-fc52dn3v 123 27 stage stage NN cord-355239-fc52dn3v 123 28 of of IN cord-355239-fc52dn3v 123 29 infection infection NN cord-355239-fc52dn3v 123 30 . . . cord-355239-fc52dn3v 124 1 In in IN cord-355239-fc52dn3v 124 2 a a DT cord-355239-fc52dn3v 124 3 situation situation NN cord-355239-fc52dn3v 124 4 where where WRB cord-355239-fc52dn3v 124 5 Peyer Peyer NNP cord-355239-fc52dn3v 124 6 's 's POS cord-355239-fc52dn3v 124 7 patches patch NNS cord-355239-fc52dn3v 124 8 are be VBP cord-355239-fc52dn3v 124 9 unavailable unavailable JJ cord-355239-fc52dn3v 124 10 because because IN cord-355239-fc52dn3v 124 11 of of IN cord-355239-fc52dn3v 124 12 an an DT cord-355239-fc52dn3v 124 13 inflammatory inflammatory JJ cord-355239-fc52dn3v 124 14 reaction reaction NN cord-355239-fc52dn3v 124 15 , , , cord-355239-fc52dn3v 124 16 Salmonella Salmonella NNP cord-355239-fc52dn3v 124 17 can can MD cord-355239-fc52dn3v 124 18 colonize colonize VB cord-355239-fc52dn3v 124 19 at at IN cord-355239-fc52dn3v 124 20 the the DT cord-355239-fc52dn3v 124 21 crypt crypt NN cord-355239-fc52dn3v 124 22 epithelium epithelium NN cord-355239-fc52dn3v 124 23 remaining remain VBG cord-355239-fc52dn3v 124 24 intact intact JJ cord-355239-fc52dn3v 124 25 and and CC cord-355239-fc52dn3v 124 26 persist persist VB cord-355239-fc52dn3v 124 27 on on IN cord-355239-fc52dn3v 124 28 the the DT cord-355239-fc52dn3v 124 29 surface surface NN cord-355239-fc52dn3v 124 30 of of IN cord-355239-fc52dn3v 124 31 the the DT cord-355239-fc52dn3v 124 32 host host NN cord-355239-fc52dn3v 124 33 intestinal intestinal JJ cord-355239-fc52dn3v 124 34 tract tract NN cord-355239-fc52dn3v 124 35 [ [ -LRB- cord-355239-fc52dn3v 124 36 13 13 CD cord-355239-fc52dn3v 124 37 , , , cord-355239-fc52dn3v 124 38 25 25 CD cord-355239-fc52dn3v 124 39 ] ] -RRB- cord-355239-fc52dn3v 124 40 . . . cord-355239-fc52dn3v 125 1 On on IN cord-355239-fc52dn3v 125 2 the the DT cord-355239-fc52dn3v 125 3 other other JJ cord-355239-fc52dn3v 125 4 hand hand NN cord-355239-fc52dn3v 125 5 , , , cord-355239-fc52dn3v 125 6 some some DT cord-355239-fc52dn3v 125 7 type type NN cord-355239-fc52dn3v 125 8 4 4 CD cord-355239-fc52dn3v 125 9 fimbriae fimbriae NN cord-355239-fc52dn3v 125 10 participate participate VB cord-355239-fc52dn3v 125 11 in in IN cord-355239-fc52dn3v 125 12 " " `` cord-355239-fc52dn3v 125 13 fimbria fimbria NN cord-355239-fc52dn3v 125 14 - - HYPH cord-355239-fc52dn3v 125 15 mediated mediate VBN cord-355239-fc52dn3v 125 16 ( ( -LRB- cord-355239-fc52dn3v 125 17 pilus pilus NN cord-355239-fc52dn3v 125 18 - - HYPH cord-355239-fc52dn3v 125 19 mediated mediate VBN cord-355239-fc52dn3v 125 20 ) ) -RRB- cord-355239-fc52dn3v 125 21 conjugal conjugal JJ cord-355239-fc52dn3v 125 22 transfer transfer NN cord-355239-fc52dn3v 125 23 " " '' cord-355239-fc52dn3v 125 24 of of IN cord-355239-fc52dn3v 125 25 so so RB cord-355239-fc52dn3v 125 26 - - HYPH cord-355239-fc52dn3v 125 27 called call VBN cord-355239-fc52dn3v 125 28 " " `` cord-355239-fc52dn3v 125 29 conjugative conjugative JJ cord-355239-fc52dn3v 125 30 plasmids plasmid NNS cord-355239-fc52dn3v 125 31 " " '' cord-355239-fc52dn3v 125 32 . . . cord-355239-fc52dn3v 126 1 Conjugative conjugative JJ cord-355239-fc52dn3v 126 2 plasmids plasmid NNS cord-355239-fc52dn3v 126 3 can can MD cord-355239-fc52dn3v 126 4 also also RB cord-355239-fc52dn3v 126 5 be be VB cord-355239-fc52dn3v 126 6 virulence virulence NN cord-355239-fc52dn3v 126 7 plasmids plasmid NNS cord-355239-fc52dn3v 126 8 if if IN cord-355239-fc52dn3v 126 9 they -PRON- PRP cord-355239-fc52dn3v 126 10 encode encode VBP cord-355239-fc52dn3v 126 11 not not RB cord-355239-fc52dn3v 126 12 only only RB cord-355239-fc52dn3v 126 13 the the DT cord-355239-fc52dn3v 126 14 structural structural JJ cord-355239-fc52dn3v 126 15 genes gene NNS cord-355239-fc52dn3v 126 16 of of IN cord-355239-fc52dn3v 126 17 the the DT cord-355239-fc52dn3v 126 18 fimbriae fimbriae NN cord-355239-fc52dn3v 126 19 but but CC cord-355239-fc52dn3v 126 20 also also RB cord-355239-fc52dn3v 126 21 other other JJ cord-355239-fc52dn3v 126 22 virulence virulence NN cord-355239-fc52dn3v 126 23 factors factor NNS cord-355239-fc52dn3v 126 24 , , , cord-355239-fc52dn3v 126 25 such such JJ cord-355239-fc52dn3v 126 26 as as IN cord-355239-fc52dn3v 126 27 a a DT cord-355239-fc52dn3v 126 28 drug drug NN cord-355239-fc52dn3v 126 29 resistance resistance NN cord-355239-fc52dn3v 126 30 gene gene NN cord-355239-fc52dn3v 126 31 . . . cord-355239-fc52dn3v 127 1 These these DT cord-355239-fc52dn3v 127 2 conjugative conjugative JJ cord-355239-fc52dn3v 127 3 plasmids plasmid NNS cord-355239-fc52dn3v 127 4 spread spread VBD cord-355239-fc52dn3v 127 5 to to IN cord-355239-fc52dn3v 127 6 other other JJ cord-355239-fc52dn3v 127 7 bacteria bacteria NNS cord-355239-fc52dn3v 127 8 by by IN cord-355239-fc52dn3v 127 9 horizontal horizontal JJ cord-355239-fc52dn3v 127 10 transfer transfer NN cord-355239-fc52dn3v 127 11 , , , cord-355239-fc52dn3v 127 12 and and CC cord-355239-fc52dn3v 127 13 type type NN cord-355239-fc52dn3v 127 14 4 4 CD cord-355239-fc52dn3v 127 15 fimbriae fimbriae NN cord-355239-fc52dn3v 127 16 encoded encode VBN cord-355239-fc52dn3v 127 17 on on IN cord-355239-fc52dn3v 127 18 the the DT cord-355239-fc52dn3v 127 19 plasmids plasmid NNS cord-355239-fc52dn3v 127 20 play play VBP cord-355239-fc52dn3v 127 21 an an DT cord-355239-fc52dn3v 127 22 important important JJ cord-355239-fc52dn3v 127 23 role role NN cord-355239-fc52dn3v 127 24 in in IN cord-355239-fc52dn3v 127 25 this this DT cord-355239-fc52dn3v 127 26 event event NN cord-355239-fc52dn3v 127 27 . . . cord-355239-fc52dn3v 128 1 For for IN cord-355239-fc52dn3v 128 2 example example NN cord-355239-fc52dn3v 128 3 , , , cord-355239-fc52dn3v 128 4 the the DT cord-355239-fc52dn3v 128 5 R64 r64 JJ cord-355239-fc52dn3v 128 6 plasmid plasmid NN cord-355239-fc52dn3v 128 7 , , , cord-355239-fc52dn3v 128 8 which which WDT cord-355239-fc52dn3v 128 9 encodes encode VBZ cord-355239-fc52dn3v 128 10 the the DT cord-355239-fc52dn3v 128 11 pilV pilv CD cord-355239-fc52dn3v 128 12 gene gene NN cord-355239-fc52dn3v 128 13 and and CC cord-355239-fc52dn3v 128 14 engages engage VBZ cord-355239-fc52dn3v 128 15 in in IN cord-355239-fc52dn3v 128 16 the the DT cord-355239-fc52dn3v 128 17 adhesion adhesion NN cord-355239-fc52dn3v 128 18 of of IN cord-355239-fc52dn3v 128 19 type type NN cord-355239-fc52dn3v 128 20 4 4 CD cord-355239-fc52dn3v 128 21 fimbriae fimbriae NN cord-355239-fc52dn3v 128 22 , , , cord-355239-fc52dn3v 128 23 recognizes recognize VBZ cord-355239-fc52dn3v 128 24 the the DT cord-355239-fc52dn3v 128 25 di di NN cord-355239-fc52dn3v 128 26 - - HYPH cord-355239-fc52dn3v 128 27 saccharide saccharide JJ cord-355239-fc52dn3v 128 28 moiety moiety NN cord-355239-fc52dn3v 128 29 of of IN cord-355239-fc52dn3v 128 30 bacterial bacterial JJ cord-355239-fc52dn3v 128 31 surface surface NN cord-355239-fc52dn3v 128 32 polysaccharides polysaccharide NNS cord-355239-fc52dn3v 128 33 ( ( -LRB- cord-355239-fc52dn3v 128 34 the the DT cord-355239-fc52dn3v 128 35 core core NN cord-355239-fc52dn3v 128 36 oligosaccharide oligosaccharide NN cord-355239-fc52dn3v 128 37 or or CC cord-355239-fc52dn3v 128 38 O o NN cord-355239-fc52dn3v 128 39 - - HYPH cord-355239-fc52dn3v 128 40 antigen antigen NN cord-355239-fc52dn3v 128 41 unit unit NN cord-355239-fc52dn3v 128 42 of of IN cord-355239-fc52dn3v 128 43 lipopolysaccharides lipopolysaccharides NNP cord-355239-fc52dn3v 128 44 , , , cord-355239-fc52dn3v 128 45 a a DT cord-355239-fc52dn3v 128 46 unique unique JJ cord-355239-fc52dn3v 128 47 structure structure NN cord-355239-fc52dn3v 128 48 of of IN cord-355239-fc52dn3v 128 49 the the DT cord-355239-fc52dn3v 128 50 bacterial bacterial JJ cord-355239-fc52dn3v 128 51 cell cell NN cord-355239-fc52dn3v 128 52 surface surface NN cord-355239-fc52dn3v 128 53 ) ) -RRB- cord-355239-fc52dn3v 128 54 and and CC cord-355239-fc52dn3v 128 55 determines determine VBZ cord-355239-fc52dn3v 128 56 the the DT cord-355239-fc52dn3v 128 57 recipient recipient NN cord-355239-fc52dn3v 128 58 bacteria bacteria NNS cord-355239-fc52dn3v 128 59 of of IN cord-355239-fc52dn3v 128 60 the the DT cord-355239-fc52dn3v 128 61 conjugal conjugal JJ cord-355239-fc52dn3v 128 62 transfer transfer NN cord-355239-fc52dn3v 128 63 [ [ -LRB- cord-355239-fc52dn3v 128 64 26 26 CD cord-355239-fc52dn3v 128 65 , , , cord-355239-fc52dn3v 128 66 27 27 CD cord-355239-fc52dn3v 128 67 ] ] -RRB- cord-355239-fc52dn3v 128 68 . . . cord-355239-fc52dn3v 129 1 Categorized categorize VBN cord-355239-fc52dn3v 129 2 as as IN cord-355239-fc52dn3v 129 3 π π NN cord-355239-fc52dn3v 129 4 - - HYPH cord-355239-fc52dn3v 129 5 fimbriae fimbriae NNP cord-355239-fc52dn3v 129 6 , , , cord-355239-fc52dn3v 129 7 the the DT cord-355239-fc52dn3v 129 8 std std NNP cord-355239-fc52dn3v 129 9 fimbriae fimbriae NNP cord-355239-fc52dn3v 129 10 are be VBP cord-355239-fc52dn3v 129 11 well well RB cord-355239-fc52dn3v 129 12 conserved conserve VBN cord-355239-fc52dn3v 129 13 among among IN cord-355239-fc52dn3v 129 14 S. S. NNP cord-355239-fc52dn3v 129 15 enterica enterica NNP cord-355239-fc52dn3v 129 16 serotypes serotype NNS cord-355239-fc52dn3v 129 17 but but CC cord-355239-fc52dn3v 129 18 absent absent JJ cord-355239-fc52dn3v 129 19 from from IN cord-355239-fc52dn3v 129 20 related related JJ cord-355239-fc52dn3v 129 21 bacterial bacterial JJ cord-355239-fc52dn3v 129 22 species specie NNS cord-355239-fc52dn3v 129 23 ( ( -LRB- cord-355239-fc52dn3v 129 24 Fig fig NN cord-355239-fc52dn3v 129 25 . . NNP cord-355239-fc52dn3v 129 26 2 2 CD cord-355239-fc52dn3v 129 27 ) ) -RRB- cord-355239-fc52dn3v 129 28 . . . cord-355239-fc52dn3v 130 1 Std Std NNP cord-355239-fc52dn3v 130 2 fimbriae fimbriae NN cord-355239-fc52dn3v 130 3 recognize recognize VB cord-355239-fc52dn3v 130 4 and and CC cord-355239-fc52dn3v 130 5 bind bind VB cord-355239-fc52dn3v 130 6 the the DT cord-355239-fc52dn3v 130 7 H h NN cord-355239-fc52dn3v 130 8 type type NN cord-355239-fc52dn3v 130 9 2 2 CD cord-355239-fc52dn3v 130 10 histo histo JJ cord-355239-fc52dn3v 130 11 - - HYPH cord-355239-fc52dn3v 130 12 blood blood NN cord-355239-fc52dn3v 130 13 group group NN cord-355239-fc52dn3v 130 14 oligosaccharide oligosaccharide NN cord-355239-fc52dn3v 130 15 , , , cord-355239-fc52dn3v 130 16 the the DT cord-355239-fc52dn3v 130 17 terminal terminal JJ cord-355239-fc52dn3v 130 18 Fucα1 Fucα1 NNS cord-355239-fc52dn3v 130 19 - - HYPH cord-355239-fc52dn3v 130 20 2Galβ1 2galβ1 CD cord-355239-fc52dn3v 130 21 - - HYPH cord-355239-fc52dn3v 130 22 4GlcNAc 4glcnac CD cord-355239-fc52dn3v 130 23 moiety moiety NN cord-355239-fc52dn3v 130 24 . . . cord-355239-fc52dn3v 131 1 This this DT cord-355239-fc52dn3v 131 2 structure structure NN cord-355239-fc52dn3v 131 3 represents represent VBZ cord-355239-fc52dn3v 131 4 the the DT cord-355239-fc52dn3v 131 5 H h NN cord-355239-fc52dn3v 131 6 type type NN cord-355239-fc52dn3v 131 7 2 2 CD cord-355239-fc52dn3v 131 8 oligosaccharide oligosaccharide NN cord-355239-fc52dn3v 131 9 of of IN cord-355239-fc52dn3v 131 10 the the DT cord-355239-fc52dn3v 131 11 O O NNP cord-355239-fc52dn3v 131 12 blood blood NN cord-355239-fc52dn3v 131 13 group group NN cord-355239-fc52dn3v 131 14 antigen antigen NN cord-355239-fc52dn3v 131 15 [ [ -LRB- cord-355239-fc52dn3v 131 16 14 14 CD cord-355239-fc52dn3v 131 17 ] ] -RRB- cord-355239-fc52dn3v 131 18 . . . cord-355239-fc52dn3v 132 1 The the DT cord-355239-fc52dn3v 132 2 H h NN cord-355239-fc52dn3v 132 3 type type NN cord-355239-fc52dn3v 132 4 2 2 CD cord-355239-fc52dn3v 132 5 oligosaccharide oligosaccharide NN cord-355239-fc52dn3v 132 6 of of IN cord-355239-fc52dn3v 132 7 the the DT cord-355239-fc52dn3v 132 8 O O NNP cord-355239-fc52dn3v 132 9 blood blood NN cord-355239-fc52dn3v 132 10 group group NN cord-355239-fc52dn3v 132 11 antigen antigen NN cord-355239-fc52dn3v 132 12 moiety moiety NN cord-355239-fc52dn3v 132 13 is be VBZ cord-355239-fc52dn3v 132 14 expressed express VBN cord-355239-fc52dn3v 132 15 as as IN cord-355239-fc52dn3v 132 16 part part NN cord-355239-fc52dn3v 132 17 of of IN cord-355239-fc52dn3v 132 18 the the DT cord-355239-fc52dn3v 132 19 mucin mucin NN cord-355239-fc52dn3v 132 20 - - HYPH cord-355239-fc52dn3v 132 21 type type NN cord-355239-fc52dn3v 132 22 sugar sugar NN cord-355239-fc52dn3v 132 23 chains chain NNS cord-355239-fc52dn3v 132 24 of of IN cord-355239-fc52dn3v 132 25 glycoproteins glycoprotein NNS cord-355239-fc52dn3v 132 26 in in IN cord-355239-fc52dn3v 132 27 the the DT cord-355239-fc52dn3v 132 28 host host NN cord-355239-fc52dn3v 132 29 cell cell NN cord-355239-fc52dn3v 132 30 . . . cord-355239-fc52dn3v 133 1 The the DT cord-355239-fc52dn3v 133 2 terminal terminal JJ cord-355239-fc52dn3v 133 3 Fucα1 Fucα1 NNS cord-355239-fc52dn3v 133 4 - - HYPH cord-355239-fc52dn3v 133 5 2 2 CD cord-355239-fc52dn3v 133 6 moiety moiety NN cord-355239-fc52dn3v 133 7 of of IN cord-355239-fc52dn3v 133 8 H h NN cord-355239-fc52dn3v 133 9 type type NN cord-355239-fc52dn3v 133 10 2 2 CD cord-355239-fc52dn3v 133 11 oligosaccharide oligosaccharide NN cord-355239-fc52dn3v 133 12 of of IN cord-355239-fc52dn3v 133 13 the the DT cord-355239-fc52dn3v 133 14 O O NNP cord-355239-fc52dn3v 133 15 blood blood NN cord-355239-fc52dn3v 133 16 group group NN cord-355239-fc52dn3v 133 17 antigen antigen NN cord-355239-fc52dn3v 133 18 is be VBZ cord-355239-fc52dn3v 133 19 essential essential JJ cord-355239-fc52dn3v 133 20 for for IN cord-355239-fc52dn3v 133 21 the the DT cord-355239-fc52dn3v 133 22 recognition recognition NN cord-355239-fc52dn3v 133 23 of of IN cord-355239-fc52dn3v 133 24 Std Std NNP cord-355239-fc52dn3v 133 25 fimbriae fimbriae NN cord-355239-fc52dn3v 133 26 ( ( -LRB- cord-355239-fc52dn3v 133 27 Fig Fig NNP cord-355239-fc52dn3v 133 28 . . . cord-355239-fc52dn3v 133 29 3 3 CD cord-355239-fc52dn3v 133 30 ) ) -RRB- cord-355239-fc52dn3v 133 31 . . . cord-355239-fc52dn3v 134 1 Carbohydrate carbohydrate NN cord-355239-fc52dn3v 134 2 molecules molecule NNS cord-355239-fc52dn3v 134 3 act act VBP cord-355239-fc52dn3v 134 4 not not RB cord-355239-fc52dn3v 134 5 only only RB cord-355239-fc52dn3v 134 6 as as IN cord-355239-fc52dn3v 134 7 " " `` cord-355239-fc52dn3v 134 8 anchors anchor NNS cord-355239-fc52dn3v 134 9 " " '' cord-355239-fc52dn3v 134 10 for for IN cord-355239-fc52dn3v 134 11 pathogens pathogen NNS cord-355239-fc52dn3v 134 12 but but CC cord-355239-fc52dn3v 134 13 also also RB cord-355239-fc52dn3v 134 14 as as IN cord-355239-fc52dn3v 134 15 the the DT cord-355239-fc52dn3v 134 16 determinants determinant NNS cord-355239-fc52dn3v 134 17 of of IN cord-355239-fc52dn3v 134 18 host host NN cord-355239-fc52dn3v 134 19 and and CC cord-355239-fc52dn3v 134 20 tissue tissue NN cord-355239-fc52dn3v 134 21 specificity specificity NN cord-355239-fc52dn3v 134 22 . . . cord-355239-fc52dn3v 135 1 The the DT cord-355239-fc52dn3v 135 2 variety variety NN cord-355239-fc52dn3v 135 3 of of IN cord-355239-fc52dn3v 135 4 adhesion adhesion NN cord-355239-fc52dn3v 135 5 factors factor NNS cord-355239-fc52dn3v 135 6 carried carry VBN cord-355239-fc52dn3v 135 7 by by IN cord-355239-fc52dn3v 135 8 a a DT cord-355239-fc52dn3v 135 9 bacterium bacterium NN cord-355239-fc52dn3v 135 10 reflects reflect VBZ cord-355239-fc52dn3v 135 11 its -PRON- PRP$ cord-355239-fc52dn3v 135 12 pathogenic pathogenic JJ cord-355239-fc52dn3v 135 13 profile profile NN cord-355239-fc52dn3v 135 14 , , , cord-355239-fc52dn3v 135 15 magnitude magnitude NN cord-355239-fc52dn3v 135 16 of of IN cord-355239-fc52dn3v 135 17 virulence virulence NN cord-355239-fc52dn3v 135 18 , , , cord-355239-fc52dn3v 135 19 host host NN cord-355239-fc52dn3v 135 20 specificity specificity NN cord-355239-fc52dn3v 135 21 , , , cord-355239-fc52dn3v 135 22 and and CC cord-355239-fc52dn3v 135 23 tissue tissue NN cord-355239-fc52dn3v 135 24 specificity specificity NN cord-355239-fc52dn3v 135 25 . . . cord-355239-fc52dn3v 136 1 In in IN cord-355239-fc52dn3v 136 2 the the DT cord-355239-fc52dn3v 136 3 case case NN cord-355239-fc52dn3v 136 4 of of IN cord-355239-fc52dn3v 136 5 Salmonella salmonella NN cord-355239-fc52dn3v 136 6 and and CC cord-355239-fc52dn3v 136 7 assortative assortative NN cord-355239-fc52dn3v 136 8 bacteria bacteria NNS cord-355239-fc52dn3v 136 9 , , , cord-355239-fc52dn3v 136 10 the the DT cord-355239-fc52dn3v 136 11 FimH FimH NNP cord-355239-fc52dn3v 136 12 adhesins adhesin NNS cord-355239-fc52dn3v 136 13 show show VBP cord-355239-fc52dn3v 136 14 amino amino NN cord-355239-fc52dn3v 136 15 acid acid NN cord-355239-fc52dn3v 136 16 sequence sequence NN cord-355239-fc52dn3v 136 17 diversity diversity NN cord-355239-fc52dn3v 136 18 . . . cord-355239-fc52dn3v 137 1 This this DT cord-355239-fc52dn3v 137 2 diversity diversity NN cord-355239-fc52dn3v 137 3 in in IN cord-355239-fc52dn3v 137 4 FimH FimH NNP cord-355239-fc52dn3v 137 5 structure structure NN cord-355239-fc52dn3v 137 6 results result NNS cord-355239-fc52dn3v 137 7 in in IN cord-355239-fc52dn3v 137 8 the the DT cord-355239-fc52dn3v 137 9 variation variation NN cord-355239-fc52dn3v 137 10 in in IN cord-355239-fc52dn3v 137 11 affinity affinity NN cord-355239-fc52dn3v 137 12 profiles profile NNS cord-355239-fc52dn3v 137 13 . . . cord-355239-fc52dn3v 138 1 E. E. NNP cord-355239-fc52dn3v 138 2 coli coli NNS cord-355239-fc52dn3v 139 1 FimH FimH NNP cord-355239-fc52dn3v 139 2 shows show VBZ cord-355239-fc52dn3v 139 3 a a DT cord-355239-fc52dn3v 139 4 high high JJ cord-355239-fc52dn3v 139 5 affinity affinity NN cord-355239-fc52dn3v 139 6 for for IN cord-355239-fc52dn3v 139 7 aromatic aromatic JJ cord-355239-fc52dn3v 139 8 αmannosides αmannoside NNS cord-355239-fc52dn3v 139 9 as as RB cord-355239-fc52dn3v 139 10 well well RB cord-355239-fc52dn3v 139 11 as as IN cord-355239-fc52dn3v 139 12 Manα1 Manα1 NNP cord-355239-fc52dn3v 139 13 - - HYPH cord-355239-fc52dn3v 139 14 3 3 CD cord-355239-fc52dn3v 139 15 structures structure NNS cord-355239-fc52dn3v 139 16 . . . cord-355239-fc52dn3v 140 1 On on IN cord-355239-fc52dn3v 140 2 the the DT cord-355239-fc52dn3v 140 3 other other JJ cord-355239-fc52dn3v 140 4 hand hand NN cord-355239-fc52dn3v 140 5 , , , cord-355239-fc52dn3v 140 6 the the DT cord-355239-fc52dn3v 140 7 FimH FimH NNP cord-355239-fc52dn3v 140 8 of of IN cord-355239-fc52dn3v 140 9 Salmonella Salmonella NNP cord-355239-fc52dn3v 140 10 species specie NNS cord-355239-fc52dn3v 140 11 shows show VBZ cord-355239-fc52dn3v 140 12 a a DT cord-355239-fc52dn3v 140 13 high high JJ cord-355239-fc52dn3v 140 14 affinity affinity NN cord-355239-fc52dn3v 140 15 for for IN cord-355239-fc52dn3v 140 16 α α NN cord-355239-fc52dn3v 140 17 - - HYPH cord-355239-fc52dn3v 140 18 mannosides mannoside NNS cord-355239-fc52dn3v 140 19 and and CC cord-355239-fc52dn3v 140 20 a a DT cord-355239-fc52dn3v 140 21 low low JJ cord-355239-fc52dn3v 140 22 affinity affinity NN cord-355239-fc52dn3v 140 23 for for IN cord-355239-fc52dn3v 140 24 aromatic aromatic JJ cord-355239-fc52dn3v 140 25 αmannosides αmannoside NNS cord-355239-fc52dn3v 140 26 [ [ -LRB- cord-355239-fc52dn3v 140 27 19 19 CD cord-355239-fc52dn3v 140 28 ] ] -RRB- cord-355239-fc52dn3v 140 29 . . . cord-355239-fc52dn3v 141 1 In in IN cord-355239-fc52dn3v 141 2 the the DT cord-355239-fc52dn3v 141 3 case case NN cord-355239-fc52dn3v 141 4 of of IN cord-355239-fc52dn3v 141 5 Salmonella Salmonella NNP cord-355239-fc52dn3v 141 6 , , , cord-355239-fc52dn3v 141 7 allelic allelic JJ cord-355239-fc52dn3v 141 8 variation variation NN cord-355239-fc52dn3v 141 9 of of IN cord-355239-fc52dn3v 141 10 FimH FimH NNP cord-355239-fc52dn3v 141 11 adhesion adhesion NN cord-355239-fc52dn3v 141 12 directs direct VBZ cord-355239-fc52dn3v 141 13 not not RB cord-355239-fc52dn3v 141 14 only only RB cord-355239-fc52dn3v 141 15 host host NN cord-355239-fc52dn3v 141 16 cellspecific cellspecific NN cord-355239-fc52dn3v 141 17 recognition recognition NN cord-355239-fc52dn3v 141 18 but but CC cord-355239-fc52dn3v 141 19 also also RB cord-355239-fc52dn3v 141 20 distinctive distinctive JJ cord-355239-fc52dn3v 141 21 binding binding NN cord-355239-fc52dn3v 141 22 to to IN cord-355239-fc52dn3v 141 23 mammalian mammalian JJ cord-355239-fc52dn3v 141 24 and and CC cord-355239-fc52dn3v 141 25 avian avian JJ cord-355239-fc52dn3v 141 26 receptors receptor NNS cord-355239-fc52dn3v 141 27 . . . cord-355239-fc52dn3v 142 1 This this DT cord-355239-fc52dn3v 142 2 allele allele NN cord-355239-fc52dn3v 142 3 - - HYPH cord-355239-fc52dn3v 142 4 specific specific JJ cord-355239-fc52dn3v 142 5 binding bind VBG cord-355239-fc52dn3v 142 6 profile profile NN cord-355239-fc52dn3v 142 7 parallels parallel VBZ cord-355239-fc52dn3v 142 8 the the DT cord-355239-fc52dn3v 142 9 host host NN cord-355239-fc52dn3v 142 10 specificity specificity NN cord-355239-fc52dn3v 142 11 of of IN cord-355239-fc52dn3v 142 12 the the DT cord-355239-fc52dn3v 142 13 respective respective JJ cord-355239-fc52dn3v 142 14 FimH FimH NNP cord-355239-fc52dn3v 142 15 - - HYPH cord-355239-fc52dn3v 142 16 expressing express VBG cord-355239-fc52dn3v 142 17 pathogen pathogen NN cord-355239-fc52dn3v 142 18 [ [ -LRB- cord-355239-fc52dn3v 142 19 28 28 CD cord-355239-fc52dn3v 142 20 ] ] -RRB- cord-355239-fc52dn3v 142 21 . . . cord-355239-fc52dn3v 143 1 Similarly similarly RB cord-355239-fc52dn3v 143 2 , , , cord-355239-fc52dn3v 143 3 the the DT cord-355239-fc52dn3v 143 4 Lewis Lewis NNP cord-355239-fc52dn3v 143 5 b b . cord-355239-fc52dn3v 143 6 ( ( -LRB- cord-355239-fc52dn3v 143 7 Le Le NNP cord-355239-fc52dn3v 143 8 b b NNP cord-355239-fc52dn3v 143 9 ) ) -RRB- cord-355239-fc52dn3v 143 10 blood blood NN cord-355239-fc52dn3v 143 11 group group NN cord-355239-fc52dn3v 143 12 phenotype phenotype NN cord-355239-fc52dn3v 143 13 in in IN cord-355239-fc52dn3v 143 14 combination combination NN cord-355239-fc52dn3v 143 15 with with IN cord-355239-fc52dn3v 143 16 secretor secretor NN cord-355239-fc52dn3v 143 17 status status NN cord-355239-fc52dn3v 143 18 may may MD cord-355239-fc52dn3v 143 19 hinder hinder VB cord-355239-fc52dn3v 143 20 colonization colonization NN cord-355239-fc52dn3v 143 21 of of IN cord-355239-fc52dn3v 143 22 Helicobacter Helicobacter NNP cord-355239-fc52dn3v 143 23 pylori pylori NN cord-355239-fc52dn3v 143 24 in in IN cord-355239-fc52dn3v 143 25 certain certain JJ cord-355239-fc52dn3v 143 26 populations population NNS cord-355239-fc52dn3v 143 27 [ [ -LRB- cord-355239-fc52dn3v 143 28 29 29 CD cord-355239-fc52dn3v 143 29 ] ] -RRB- cord-355239-fc52dn3v 143 30 . . . cord-355239-fc52dn3v 144 1 H. H. NNP cord-355239-fc52dn3v 144 2 pylori pylori NNP cord-355239-fc52dn3v 144 3 express express NNP cord-355239-fc52dn3v 144 4 blood blood NN cord-355239-fc52dn3v 144 5 group group NN cord-355239-fc52dn3v 144 6 antigen antigen NNP cord-355239-fc52dn3v 144 7 b b NN cord-355239-fc52dn3v 144 8 - - HYPH cord-355239-fc52dn3v 144 9 binding bind VBG cord-355239-fc52dn3v 144 10 adhesion adhesion NN cord-355239-fc52dn3v 144 11 ( ( -LRB- cord-355239-fc52dn3v 144 12 BabA BabA NNP cord-355239-fc52dn3v 144 13 ) ) -RRB- cord-355239-fc52dn3v 144 14 , , , cord-355239-fc52dn3v 144 15 and and CC cord-355239-fc52dn3v 144 16 BabA BabA NNP cord-355239-fc52dn3v 144 17 binds bind VBZ cord-355239-fc52dn3v 144 18 to to IN cord-355239-fc52dn3v 144 19 Le Le NNP cord-355239-fc52dn3v 144 20 b b NNP cord-355239-fc52dn3v 144 21 antigens antigen NNS cord-355239-fc52dn3v 144 22 . . . cord-355239-fc52dn3v 145 1 Salmonella salmonella NN cord-355239-fc52dn3v 145 2 and and CC cord-355239-fc52dn3v 145 3 assortative assortative NN cord-355239-fc52dn3v 145 4 bacteria bacteria NNS cord-355239-fc52dn3v 145 5 contain contain VBP cord-355239-fc52dn3v 145 6 various various JJ cord-355239-fc52dn3v 145 7 adhesion adhesion NN cord-355239-fc52dn3v 145 8 factors factor NNS cord-355239-fc52dn3v 145 9 , , , cord-355239-fc52dn3v 145 10 including include VBG cord-355239-fc52dn3v 145 11 several several JJ cord-355239-fc52dn3v 145 12 kinds kind NNS cord-355239-fc52dn3v 145 13 of of IN cord-355239-fc52dn3v 145 14 fimbriae fimbriae NN cord-355239-fc52dn3v 145 15 , , , cord-355239-fc52dn3v 145 16 which which WDT cord-355239-fc52dn3v 145 17 contribute contribute VBP cord-355239-fc52dn3v 145 18 to to IN cord-355239-fc52dn3v 145 19 bacterial bacterial JJ cord-355239-fc52dn3v 145 20 virulence virulence NN cord-355239-fc52dn3v 145 21 ; ; : cord-355239-fc52dn3v 145 22 however however RB cord-355239-fc52dn3v 145 23 , , , cord-355239-fc52dn3v 145 24 analyses analysis NNS cord-355239-fc52dn3v 145 25 of of IN cord-355239-fc52dn3v 145 26 their -PRON- PRP$ cord-355239-fc52dn3v 145 27 specific specific JJ cord-355239-fc52dn3v 145 28 receptor receptor NN cord-355239-fc52dn3v 145 29 moieties moiety NNS cord-355239-fc52dn3v 145 30 and and CC cord-355239-fc52dn3v 145 31 functions function NNS cord-355239-fc52dn3v 145 32 are be VBP cord-355239-fc52dn3v 145 33 not not RB cord-355239-fc52dn3v 145 34 yet yet RB cord-355239-fc52dn3v 145 35 complete complete JJ cord-355239-fc52dn3v 145 36 [ [ -LRB- cord-355239-fc52dn3v 145 37 13 13 CD cord-355239-fc52dn3v 145 38 , , , cord-355239-fc52dn3v 145 39 15 15 CD cord-355239-fc52dn3v 145 40 ] ] -RRB- cord-355239-fc52dn3v 145 41 . . . cord-355239-fc52dn3v 146 1 Carbohydrate carbohydrate NN cord-355239-fc52dn3v 146 2 moieties moiety NNS cord-355239-fc52dn3v 146 3 on on IN cord-355239-fc52dn3v 146 4 the the DT cord-355239-fc52dn3v 146 5 surface surface NN cord-355239-fc52dn3v 146 6 of of IN cord-355239-fc52dn3v 146 7 pathogens pathogen NNS cord-355239-fc52dn3v 146 8 are be VBP cord-355239-fc52dn3v 146 9 also also RB cord-355239-fc52dn3v 146 10 recognized recognize VBN cord-355239-fc52dn3v 146 11 by by IN cord-355239-fc52dn3v 146 12 hosts host NNS cord-355239-fc52dn3v 146 13 and and CC cord-355239-fc52dn3v 146 14 trigger trigger NN cord-355239-fc52dn3v 146 15 host host NN cord-355239-fc52dn3v 146 16 defense defense NN cord-355239-fc52dn3v 146 17 mechanisms mechanism NNS cord-355239-fc52dn3v 146 18 . . . cord-355239-fc52dn3v 147 1 The the DT cord-355239-fc52dn3v 147 2 bacterial bacterial JJ cord-355239-fc52dn3v 147 3 surface surface NN cord-355239-fc52dn3v 147 4 is be VBZ cord-355239-fc52dn3v 147 5 covered cover VBN cord-355239-fc52dn3v 147 6 with with IN cord-355239-fc52dn3v 147 7 various various JJ cord-355239-fc52dn3v 147 8 kinds kind NNS cord-355239-fc52dn3v 147 9 of of IN cord-355239-fc52dn3v 147 10 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 147 11 . . . cord-355239-fc52dn3v 148 1 For for IN cord-355239-fc52dn3v 148 2 gram gram NN cord-355239-fc52dn3v 148 3 - - HYPH cord-355239-fc52dn3v 148 4 negative negative JJ cord-355239-fc52dn3v 148 5 bacteria bacteria NNS cord-355239-fc52dn3v 148 6 , , , cord-355239-fc52dn3v 148 7 including include VBG cord-355239-fc52dn3v 148 8 Salmonella Salmonella NNP cord-355239-fc52dn3v 148 9 , , , cord-355239-fc52dn3v 148 10 the the DT cord-355239-fc52dn3v 148 11 major major JJ cord-355239-fc52dn3v 148 12 carbohydrate carbohydrate NN cord-355239-fc52dn3v 148 13 component component NN cord-355239-fc52dn3v 148 14 of of IN cord-355239-fc52dn3v 148 15 the the DT cord-355239-fc52dn3v 148 16 bacterial bacterial JJ cord-355239-fc52dn3v 148 17 surface surface NN cord-355239-fc52dn3v 148 18 is be VBZ cord-355239-fc52dn3v 148 19 lipopolysaccharide lipopolysaccharide NN cord-355239-fc52dn3v 148 20 ( ( -LRB- cord-355239-fc52dn3v 148 21 LPS LPS NNP cord-355239-fc52dn3v 148 22 ) ) -RRB- cord-355239-fc52dn3v 148 23 . . . cord-355239-fc52dn3v 149 1 LPS LPS NNP cord-355239-fc52dn3v 149 2 is be VBZ cord-355239-fc52dn3v 149 3 categorized categorize VBN cord-355239-fc52dn3v 149 4 as as IN cord-355239-fc52dn3v 149 5 a a DT cord-355239-fc52dn3v 149 6 glycolipid glycolipid NN cord-355239-fc52dn3v 149 7 , , , cord-355239-fc52dn3v 149 8 and and CC cord-355239-fc52dn3v 149 9 is be VBZ cord-355239-fc52dn3v 149 10 a a DT cord-355239-fc52dn3v 149 11 major major JJ cord-355239-fc52dn3v 149 12 component component NN cord-355239-fc52dn3v 149 13 of of IN cord-355239-fc52dn3v 149 14 the the DT cord-355239-fc52dn3v 149 15 bacterial bacterial JJ cord-355239-fc52dn3v 149 16 outer outer JJ cord-355239-fc52dn3v 149 17 membrane membrane NN cord-355239-fc52dn3v 149 18 . . . cord-355239-fc52dn3v 150 1 Because because IN cord-355239-fc52dn3v 150 2 the the DT cord-355239-fc52dn3v 150 3 saccharide saccharide NN cord-355239-fc52dn3v 150 4 moieties moiety NNS cord-355239-fc52dn3v 150 5 of of IN cord-355239-fc52dn3v 150 6 LPS lp NNS cord-355239-fc52dn3v 150 7 differ differ VBP cord-355239-fc52dn3v 150 8 structurally structurally RB cord-355239-fc52dn3v 150 9 from from IN cord-355239-fc52dn3v 150 10 mammalian mammalian JJ cord-355239-fc52dn3v 150 11 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 150 12 , , , cord-355239-fc52dn3v 150 13 they -PRON- PRP cord-355239-fc52dn3v 150 14 function function VBP cord-355239-fc52dn3v 150 15 as as IN cord-355239-fc52dn3v 150 16 targets target NNS cord-355239-fc52dn3v 150 17 of of IN cord-355239-fc52dn3v 150 18 the the DT cord-355239-fc52dn3v 150 19 host host NN cord-355239-fc52dn3v 150 20 immune immune JJ cord-355239-fc52dn3v 150 21 response response NN cord-355239-fc52dn3v 150 22 . . . cord-355239-fc52dn3v 151 1 To to TO cord-355239-fc52dn3v 151 2 avoid avoid VB cord-355239-fc52dn3v 151 3 this this DT cord-355239-fc52dn3v 151 4 host host NN cord-355239-fc52dn3v 151 5 immune immune JJ cord-355239-fc52dn3v 151 6 response response NN cord-355239-fc52dn3v 151 7 , , , cord-355239-fc52dn3v 151 8 the the DT cord-355239-fc52dn3v 151 9 LPS lp NNS cord-355239-fc52dn3v 151 10 of of IN cord-355239-fc52dn3v 151 11 some some DT cord-355239-fc52dn3v 151 12 bacteria bacteria NNS cord-355239-fc52dn3v 151 13 , , , cord-355239-fc52dn3v 151 14 for for IN cord-355239-fc52dn3v 151 15 example example NN cord-355239-fc52dn3v 151 16 C. C. NNP cord-355239-fc52dn3v 151 17 jejuni jejuni NNP cord-355239-fc52dn3v 151 18 , , , cord-355239-fc52dn3v 151 19 is be VBZ cord-355239-fc52dn3v 151 20 structurally structurally RB cord-355239-fc52dn3v 151 21 similar similar JJ cord-355239-fc52dn3v 151 22 to to IN cord-355239-fc52dn3v 151 23 the the DT cord-355239-fc52dn3v 151 24 glycosphingolipids glycosphingolipid NNS cord-355239-fc52dn3v 151 25 of of IN cord-355239-fc52dn3v 151 26 gangliosides gangliosides NNPS cord-355239-fc52dn3v 151 27 [ [ -LRB- cord-355239-fc52dn3v 151 28 30 30 CD cord-355239-fc52dn3v 151 29 , , , cord-355239-fc52dn3v 151 30 31 31 CD cord-355239-fc52dn3v 151 31 ] ] -RRB- cord-355239-fc52dn3v 151 32 . . . cord-355239-fc52dn3v 152 1 Similarly similarly RB cord-355239-fc52dn3v 152 2 , , , cord-355239-fc52dn3v 152 3 the the DT cord-355239-fc52dn3v 152 4 LPS lp NNS cord-355239-fc52dn3v 152 5 of of IN cord-355239-fc52dn3v 152 6 most most JJS cord-355239-fc52dn3v 152 7 H. h. NN cord-355239-fc52dn3v 152 8 pylori pylori NN cord-355239-fc52dn3v 152 9 strains strain NNS cord-355239-fc52dn3v 152 10 expresses express VBZ cord-355239-fc52dn3v 152 11 the the DT cord-355239-fc52dn3v 152 12 Le Le NNP cord-355239-fc52dn3v 152 13 a a NNP cord-355239-fc52dn3v 152 14 and and CC cord-355239-fc52dn3v 152 15 Le Le NNP cord-355239-fc52dn3v 152 16 b b NNP cord-355239-fc52dn3v 152 17 antigens antigen NNS cord-355239-fc52dn3v 152 18 [ [ -LRB- cord-355239-fc52dn3v 152 19 29 29 CD cord-355239-fc52dn3v 152 20 ] ] -RRB- cord-355239-fc52dn3v 152 21 . . . cord-355239-fc52dn3v 153 1 Interestingly interestingly RB cord-355239-fc52dn3v 153 2 , , , cord-355239-fc52dn3v 153 3 the the DT cord-355239-fc52dn3v 153 4 carbohydrate carbohydrate NN cord-355239-fc52dn3v 153 5 on on IN cord-355239-fc52dn3v 153 6 the the DT cord-355239-fc52dn3v 153 7 surface surface NN cord-355239-fc52dn3v 153 8 of of IN cord-355239-fc52dn3v 153 9 the the DT cord-355239-fc52dn3v 153 10 K. K. NNP cord-355239-fc52dn3v 153 11 Kato Kato NNP cord-355239-fc52dn3v 153 12 et et NNP cord-355239-fc52dn3v 153 13 al al NNP cord-355239-fc52dn3v 153 14 . . . cord-355239-fc52dn3v 154 1 45 45 CD cord-355239-fc52dn3v 154 2 host host NN cord-355239-fc52dn3v 154 3 cell cell NN cord-355239-fc52dn3v 154 4 itself -PRON- PRP cord-355239-fc52dn3v 154 5 can can MD cord-355239-fc52dn3v 154 6 be be VB cord-355239-fc52dn3v 154 7 involved involve VBN cord-355239-fc52dn3v 154 8 in in IN cord-355239-fc52dn3v 154 9 the the DT cord-355239-fc52dn3v 154 10 host host NN cord-355239-fc52dn3v 154 11 defense defense NN cord-355239-fc52dn3v 154 12 mechanism mechanism NN cord-355239-fc52dn3v 154 13 . . . cord-355239-fc52dn3v 155 1 The the DT cord-355239-fc52dn3v 155 2 Salmonella Salmonella NNP cord-355239-fc52dn3v 155 3 flagella flagella VBZ cord-355239-fc52dn3v 155 4 component component NN cord-355239-fc52dn3v 155 5 FliC flic NN cord-355239-fc52dn3v 155 6 contributes contribute VBZ cord-355239-fc52dn3v 155 7 to to IN cord-355239-fc52dn3v 155 8 bacterial bacterial JJ cord-355239-fc52dn3v 155 9 attachment attachment NN cord-355239-fc52dn3v 155 10 to to IN cord-355239-fc52dn3v 155 11 the the DT cord-355239-fc52dn3v 155 12 host host NN cord-355239-fc52dn3v 155 13 cell cell NN cord-355239-fc52dn3v 155 14 by by IN cord-355239-fc52dn3v 155 15 interacting interact VBG cord-355239-fc52dn3v 155 16 with with IN cord-355239-fc52dn3v 155 17 ganglioside ganglioside NN cord-355239-fc52dn3v 155 18 molecules molecule NNS cord-355239-fc52dn3v 155 19 on on IN cord-355239-fc52dn3v 155 20 the the DT cord-355239-fc52dn3v 155 21 surface surface NN cord-355239-fc52dn3v 155 22 of of IN cord-355239-fc52dn3v 155 23 the the DT cord-355239-fc52dn3v 155 24 host host NN cord-355239-fc52dn3v 155 25 cell cell NN cord-355239-fc52dn3v 155 26 , , , cord-355239-fc52dn3v 155 27 but but CC cord-355239-fc52dn3v 155 28 gangliosides gangliosides NNP cord-355239-fc52dn3v 155 29 also also RB cord-355239-fc52dn3v 155 30 act act VBP cord-355239-fc52dn3v 155 31 as as IN cord-355239-fc52dn3v 155 32 co co NNS cord-355239-fc52dn3v 155 33 - - NNS cord-355239-fc52dn3v 155 34 receptors receptor NNS cord-355239-fc52dn3v 155 35 for for IN cord-355239-fc52dn3v 155 36 Salmonella Salmonella NNP cord-355239-fc52dn3v 155 37 enterica enterica NNP cord-355239-fc52dn3v 155 38 FliC FliC NNP cord-355239-fc52dn3v 155 39 and and CC cord-355239-fc52dn3v 155 40 promote promote VB cord-355239-fc52dn3v 155 41 FliC flic NN cord-355239-fc52dn3v 155 42 induction induction NN cord-355239-fc52dn3v 155 43 of of IN cord-355239-fc52dn3v 155 44 the the DT cord-355239-fc52dn3v 155 45 human human JJ cord-355239-fc52dn3v 155 46 innate innate JJ cord-355239-fc52dn3v 155 47 immune immune JJ cord-355239-fc52dn3v 155 48 response response NN cord-355239-fc52dn3v 155 49 [ [ -LRB- cord-355239-fc52dn3v 155 50 32 32 CD cord-355239-fc52dn3v 155 51 ] ] -RRB- cord-355239-fc52dn3v 155 52 . . . cord-355239-fc52dn3v 156 1 Gangliosides ganglioside NNS cord-355239-fc52dn3v 156 2 , , , cord-355239-fc52dn3v 156 3 i.e. i.e. FW cord-355239-fc52dn3v 156 4 sialic sialic JJ cord-355239-fc52dn3v 156 5 acidcontaining acidcontaining NN cord-355239-fc52dn3v 156 6 glycosphingolipids glycosphingolipid NNS cord-355239-fc52dn3v 156 7 , , , cord-355239-fc52dn3v 156 8 are be VBP cord-355239-fc52dn3v 156 9 ubiquitous ubiquitous JJ cord-355239-fc52dn3v 156 10 components component NNS cord-355239-fc52dn3v 156 11 of of IN cord-355239-fc52dn3v 156 12 eukaryotic eukaryotic JJ cord-355239-fc52dn3v 156 13 cell cell NN cord-355239-fc52dn3v 156 14 membranes membrane NNS cord-355239-fc52dn3v 156 15 that that WDT cord-355239-fc52dn3v 156 16 have have VBP cord-355239-fc52dn3v 156 17 been be VBN cord-355239-fc52dn3v 156 18 identified identify VBN cord-355239-fc52dn3v 156 19 as as IN cord-355239-fc52dn3v 156 20 receptors receptor NNS cord-355239-fc52dn3v 156 21 for for IN cord-355239-fc52dn3v 156 22 bacterial bacterial JJ cord-355239-fc52dn3v 156 23 toxins toxin NNS cord-355239-fc52dn3v 156 24 and and CC cord-355239-fc52dn3v 156 25 viruses virus NNS cord-355239-fc52dn3v 156 26 . . . cord-355239-fc52dn3v 157 1 An an DT cord-355239-fc52dn3v 157 2 in in FW cord-355239-fc52dn3v 157 3 vitro vitro FW cord-355239-fc52dn3v 157 4 assay assay NN cord-355239-fc52dn3v 157 5 showed show VBD cord-355239-fc52dn3v 157 6 that that IN cord-355239-fc52dn3v 157 7 a a DT cord-355239-fc52dn3v 157 8 nonflagellated nonflagellated JJ cord-355239-fc52dn3v 157 9 mutant mutant NN cord-355239-fc52dn3v 157 10 of of IN cord-355239-fc52dn3v 157 11 S. S. NNP cord-355239-fc52dn3v 157 12 enteritidis enteritidis NN cord-355239-fc52dn3v 157 13 , , , cord-355239-fc52dn3v 157 14 constructed construct VBN cord-355239-fc52dn3v 157 15 by by IN cord-355239-fc52dn3v 157 16 disrupting disrupt VBG cord-355239-fc52dn3v 157 17 the the DT cord-355239-fc52dn3v 157 18 fliC flic NN cord-355239-fc52dn3v 157 19 gene gene NN cord-355239-fc52dn3v 157 20 , , , cord-355239-fc52dn3v 157 21 was be VBD cord-355239-fc52dn3v 157 22 about about RB cord-355239-fc52dn3v 157 23 50-fold 50-fold JJ cord-355239-fc52dn3v 157 24 less less RBR cord-355239-fc52dn3v 157 25 invasive invasive JJ cord-355239-fc52dn3v 157 26 than than IN cord-355239-fc52dn3v 157 27 the the DT cord-355239-fc52dn3v 157 28 wild wild JJ cord-355239-fc52dn3v 157 29 - - HYPH cord-355239-fc52dn3v 157 30 type type NN cord-355239-fc52dn3v 157 31 strain strain NN cord-355239-fc52dn3v 157 32 , , , cord-355239-fc52dn3v 157 33 but but CC cord-355239-fc52dn3v 157 34 bacterial bacterial JJ cord-355239-fc52dn3v 157 35 adherence adherence NN cord-355239-fc52dn3v 157 36 was be VBD cord-355239-fc52dn3v 157 37 unaffected unaffected JJ cord-355239-fc52dn3v 157 38 [ [ -LRB- cord-355239-fc52dn3v 157 39 33 33 CD cord-355239-fc52dn3v 157 40 ] ] -RRB- cord-355239-fc52dn3v 157 41 . . . cord-355239-fc52dn3v 158 1 At at IN cord-355239-fc52dn3v 158 2 the the DT cord-355239-fc52dn3v 158 3 attachment attachment NN cord-355239-fc52dn3v 158 4 of of IN cord-355239-fc52dn3v 158 5 Salmonella Salmonella NNP cord-355239-fc52dn3v 158 6 enteritidis enteritidis NN cord-355239-fc52dn3v 158 7 FliC flic NN cord-355239-fc52dn3v 158 8 to to IN cord-355239-fc52dn3v 158 9 the the DT cord-355239-fc52dn3v 158 10 host host NN cord-355239-fc52dn3v 158 11 cell cell NN cord-355239-fc52dn3v 158 12 surface surface NN cord-355239-fc52dn3v 158 13 , , , cord-355239-fc52dn3v 158 14 gangliosides ganglioside NNS cord-355239-fc52dn3v 158 15 thus thus RB cord-355239-fc52dn3v 158 16 function function VBP cord-355239-fc52dn3v 158 17 as as IN cord-355239-fc52dn3v 158 18 receptors receptor NNS cord-355239-fc52dn3v 158 19 . . . cord-355239-fc52dn3v 159 1 On on IN cord-355239-fc52dn3v 159 2 the the DT cord-355239-fc52dn3v 159 3 other other JJ cord-355239-fc52dn3v 159 4 hand hand NN cord-355239-fc52dn3v 159 5 , , , cord-355239-fc52dn3v 159 6 the the DT cord-355239-fc52dn3v 159 7 flagella flagella NNP cord-355239-fc52dn3v 159 8 component component NN cord-355239-fc52dn3v 159 9 protein protein NN cord-355239-fc52dn3v 159 10 FliC FliC NNP cord-355239-fc52dn3v 159 11 induces induce VBZ cord-355239-fc52dn3v 159 12 the the DT cord-355239-fc52dn3v 159 13 host host NN cord-355239-fc52dn3v 159 14 innate innate JJ cord-355239-fc52dn3v 159 15 immune immune JJ cord-355239-fc52dn3v 159 16 response response NN cord-355239-fc52dn3v 159 17 by by IN cord-355239-fc52dn3v 159 18 binding bind VBG cord-355239-fc52dn3v 159 19 to to IN cord-355239-fc52dn3v 159 20 Toll Toll NNP cord-355239-fc52dn3v 159 21 - - HYPH cord-355239-fc52dn3v 159 22 like like JJ cord-355239-fc52dn3v 159 23 receptor receptor NN cord-355239-fc52dn3v 159 24 5 5 CD cord-355239-fc52dn3v 159 25 of of IN cord-355239-fc52dn3v 159 26 the the DT cord-355239-fc52dn3v 159 27 host host NN cord-355239-fc52dn3v 159 28 cell cell NN cord-355239-fc52dn3v 159 29 , , , cord-355239-fc52dn3v 159 30 and and CC cord-355239-fc52dn3v 159 31 gangliosides ganglioside NNS cord-355239-fc52dn3v 159 32 react react VBP cord-355239-fc52dn3v 159 33 as as IN cord-355239-fc52dn3v 159 34 co co NNS cord-355239-fc52dn3v 159 35 - - NNS cord-355239-fc52dn3v 159 36 receptors receptor NNS cord-355239-fc52dn3v 159 37 with with IN cord-355239-fc52dn3v 159 38 TLR5 TLR5 NNP cord-355239-fc52dn3v 159 39 on on IN cord-355239-fc52dn3v 159 40 the the DT cord-355239-fc52dn3v 159 41 FliC flic NN cord-355239-fc52dn3v 159 42 - - HYPH cord-355239-fc52dn3v 159 43 induced induce VBN cord-355239-fc52dn3v 159 44 response response NN cord-355239-fc52dn3v 159 45 . . . cord-355239-fc52dn3v 160 1 An an DT cord-355239-fc52dn3v 160 2 in in FW cord-355239-fc52dn3v 160 3 vitro vitro FW cord-355239-fc52dn3v 160 4 assay assay NN cord-355239-fc52dn3v 160 5 showed show VBD cord-355239-fc52dn3v 160 6 that that IN cord-355239-fc52dn3v 160 7 the the DT cord-355239-fc52dn3v 160 8 incorporation incorporation NN cord-355239-fc52dn3v 160 9 of of IN cord-355239-fc52dn3v 160 10 exogenous exogenous JJ cord-355239-fc52dn3v 160 11 ganglioside ganglioside NN cord-355239-fc52dn3v 160 12 GD1a GD1a NNP cord-355239-fc52dn3v 160 13 into into IN cord-355239-fc52dn3v 160 14 the the DT cord-355239-fc52dn3v 160 15 Caco-2 Caco-2 NNP cord-355239-fc52dn3v 160 16 cell cell NN cord-355239-fc52dn3v 160 17 membrane membrane NN cord-355239-fc52dn3v 160 18 increased increase VBD cord-355239-fc52dn3v 160 19 the the DT cord-355239-fc52dn3v 160 20 effect effect NN cord-355239-fc52dn3v 160 21 of of IN cord-355239-fc52dn3v 160 22 FliC. FliC. NNP cord-355239-fc52dn3v 160 23 Incubation Incubation NNP cord-355239-fc52dn3v 160 24 of of IN cord-355239-fc52dn3v 160 25 Caco-2 Caco-2 NNP cord-355239-fc52dn3v 160 26 cells cell NNS cord-355239-fc52dn3v 160 27 with with IN cord-355239-fc52dn3v 160 28 a a DT cord-355239-fc52dn3v 160 29 glucosylceramide glucosylceramide JJ cord-355239-fc52dn3v 160 30 synthase synthase NN cord-355239-fc52dn3v 160 31 inhibitor inhibitor NN cord-355239-fc52dn3v 160 32 reduced reduce VBD cord-355239-fc52dn3v 160 33 the the DT cord-355239-fc52dn3v 160 34 innate innate JJ cord-355239-fc52dn3v 160 35 immune immune JJ cord-355239-fc52dn3v 160 36 response response NN cord-355239-fc52dn3v 160 37 stimulated stimulate VBN cord-355239-fc52dn3v 160 38 by by IN cord-355239-fc52dn3v 160 39 FliC flic NN cord-355239-fc52dn3v 160 40 [ [ -LRB- cord-355239-fc52dn3v 160 41 32 32 CD cord-355239-fc52dn3v 160 42 ] ] -RRB- cord-355239-fc52dn3v 160 43 . . . cord-355239-fc52dn3v 161 1 Human human JJ cord-355239-fc52dn3v 161 2 enteropathogenic enteropathogenic JJ cord-355239-fc52dn3v 161 3 protozoas protozoas NN cord-355239-fc52dn3v 161 4 include include VBP cord-355239-fc52dn3v 161 5 the the DT cord-355239-fc52dn3v 161 6 apicomplexans apicomplexan NNS cord-355239-fc52dn3v 161 7 Toxoplasma Toxoplasma NNP cord-355239-fc52dn3v 161 8 gondii gondii NN cord-355239-fc52dn3v 161 9 and and CC cord-355239-fc52dn3v 161 10 Cryptosporidium cryptosporidium NN cord-355239-fc52dn3v 161 11 as as RB cord-355239-fc52dn3v 161 12 well well RB cord-355239-fc52dn3v 161 13 as as IN cord-355239-fc52dn3v 161 14 Giardia Giardia NNP cord-355239-fc52dn3v 161 15 and and CC cord-355239-fc52dn3v 161 16 Entamoeba Entamoeba NNP cord-355239-fc52dn3v 161 17 histolytica histolytica NNP cord-355239-fc52dn3v 161 18 . . . cord-355239-fc52dn3v 162 1 They -PRON- PRP cord-355239-fc52dn3v 162 2 are be VBP cord-355239-fc52dn3v 162 3 all all RB cord-355239-fc52dn3v 162 4 zoonotic zoonotic JJ cord-355239-fc52dn3v 162 5 pathogens pathogen NNS cord-355239-fc52dn3v 162 6 that that WDT cord-355239-fc52dn3v 162 7 invade invade VBP cord-355239-fc52dn3v 162 8 and and CC cord-355239-fc52dn3v 162 9 colonize colonize VB cord-355239-fc52dn3v 162 10 their -PRON- PRP$ cord-355239-fc52dn3v 162 11 target target NN cord-355239-fc52dn3v 162 12 tissues tissue NNS cord-355239-fc52dn3v 162 13 in in IN cord-355239-fc52dn3v 162 14 the the DT cord-355239-fc52dn3v 162 15 alimentary alimentary JJ cord-355239-fc52dn3v 162 16 tract tract NN cord-355239-fc52dn3v 162 17 of of IN cord-355239-fc52dn3v 162 18 the the DT cord-355239-fc52dn3v 162 19 human human JJ cord-355239-fc52dn3v 162 20 host host NN cord-355239-fc52dn3v 162 21 . . . cord-355239-fc52dn3v 163 1 They -PRON- PRP cord-355239-fc52dn3v 163 2 form form VBP cord-355239-fc52dn3v 163 3 hard hard JJ cord-355239-fc52dn3v 163 4 cysts cyst NNS cord-355239-fc52dn3v 163 5 that that WDT cord-355239-fc52dn3v 163 6 resist resist VBP cord-355239-fc52dn3v 163 7 degradation degradation NN cord-355239-fc52dn3v 163 8 in in IN cord-355239-fc52dn3v 163 9 the the DT cord-355239-fc52dn3v 163 10 stomach stomach NN cord-355239-fc52dn3v 163 11 . . . cord-355239-fc52dn3v 164 1 Host host NN cord-355239-fc52dn3v 164 2 - - HYPH cord-355239-fc52dn3v 164 3 derived derive VBN cord-355239-fc52dn3v 164 4 proteases protease NNS cord-355239-fc52dn3v 164 5 and and CC cord-355239-fc52dn3v 164 6 low low JJ cord-355239-fc52dn3v 164 7 pH ph NN cord-355239-fc52dn3v 164 8 trigger trigger VB cord-355239-fc52dn3v 164 9 their -PRON- PRP$ cord-355239-fc52dn3v 164 10 excystation excystation NN cord-355239-fc52dn3v 164 11 [ [ -LRB- cord-355239-fc52dn3v 164 12 34 34 CD cord-355239-fc52dn3v 164 13 ] ] -RRB- cord-355239-fc52dn3v 164 14 . . . cord-355239-fc52dn3v 165 1 In in IN cord-355239-fc52dn3v 165 2 this this DT cord-355239-fc52dn3v 165 3 section section NN cord-355239-fc52dn3v 165 4 , , , cord-355239-fc52dn3v 165 5 we -PRON- PRP cord-355239-fc52dn3v 165 6 describe describe VBP cord-355239-fc52dn3v 165 7 the the DT cord-355239-fc52dn3v 165 8 role role NN cord-355239-fc52dn3v 165 9 of of IN cord-355239-fc52dn3v 165 10 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 165 11 in in IN cord-355239-fc52dn3v 165 12 Toxoplasma Toxoplasma NNP cord-355239-fc52dn3v 165 13 gondii gondii NNP cord-355239-fc52dn3v 165 14 invasion invasion NN cord-355239-fc52dn3v 165 15 of of IN cord-355239-fc52dn3v 165 16 intestinal intestinal JJ cord-355239-fc52dn3v 165 17 epithelial epithelial JJ cord-355239-fc52dn3v 165 18 cells cell NNS cord-355239-fc52dn3v 165 19 . . . cord-355239-fc52dn3v 166 1 The the DT cord-355239-fc52dn3v 166 2 ability ability NN cord-355239-fc52dn3v 166 3 of of IN cord-355239-fc52dn3v 166 4 T. t. NN cord-355239-fc52dn3v 166 5 gondii gondii NN cord-355239-fc52dn3v 166 6 to to TO cord-355239-fc52dn3v 166 7 infect infect VB cord-355239-fc52dn3v 166 8 Chinese chinese JJ cord-355239-fc52dn3v 166 9 hamster hamster NN cord-355239-fc52dn3v 166 10 ovary ovary NN cord-355239-fc52dn3v 166 11 ( ( -LRB- cord-355239-fc52dn3v 166 12 CHO CHO NNP cord-355239-fc52dn3v 166 13 ) ) -RRB- cord-355239-fc52dn3v 166 14 cells cell NNS cord-355239-fc52dn3v 166 15 deficient deficient JJ cord-355239-fc52dn3v 166 16 in in IN cord-355239-fc52dn3v 166 17 sialic sialic JJ cord-355239-fc52dn3v 166 18 acids acid NNS cord-355239-fc52dn3v 166 19 was be VBD cord-355239-fc52dn3v 166 20 reduced reduce VBN cord-355239-fc52dn3v 166 21 by by IN cord-355239-fc52dn3v 166 22 26.9 26.9 CD cord-355239-fc52dn3v 166 23 % % NN cord-355239-fc52dn3v 166 24 compared compare VBN cord-355239-fc52dn3v 166 25 to to IN cord-355239-fc52dn3v 166 26 wild wild JJ cord-355239-fc52dn3v 166 27 - - HYPH cord-355239-fc52dn3v 166 28 type type NN cord-355239-fc52dn3v 166 29 cells cell NNS cord-355239-fc52dn3v 166 30 , , , cord-355239-fc52dn3v 166 31 indicating indicate VBG cord-355239-fc52dn3v 166 32 that that IN cord-355239-fc52dn3v 166 33 sialic sialic JJ cord-355239-fc52dn3v 166 34 acid acid NN cord-355239-fc52dn3v 166 35 is be VBZ cord-355239-fc52dn3v 166 36 critical critical JJ cord-355239-fc52dn3v 166 37 for for IN cord-355239-fc52dn3v 166 38 attachment attachment NN cord-355239-fc52dn3v 166 39 and and CC cord-355239-fc52dn3v 166 40 invasion invasion NN cord-355239-fc52dn3v 166 41 of of IN cord-355239-fc52dn3v 166 42 T. t. NN cord-355239-fc52dn3v 166 43 gondii gondii NNP cord-355239-fc52dn3v 166 44 ( ( -LRB- cord-355239-fc52dn3v 166 45 Fig Fig NNP cord-355239-fc52dn3v 166 46 . . . cord-355239-fc52dn3v 166 47 4 4 CD cord-355239-fc52dn3v 166 48 ) ) -RRB- cord-355239-fc52dn3v 167 1 [ [ -LRB- cord-355239-fc52dn3v 167 2 35 35 CD cord-355239-fc52dn3v 167 3 ] ] -RRB- cord-355239-fc52dn3v 167 4 . . . cord-355239-fc52dn3v 168 1 T. T. NNP cord-355239-fc52dn3v 168 2 gondii gondii NNP cord-355239-fc52dn3v 168 3 microneme microneme NN cord-355239-fc52dn3v 168 4 protein protein NN cord-355239-fc52dn3v 168 5 1 1 CD cord-355239-fc52dn3v 169 1 ( ( -LRB- cord-355239-fc52dn3v 169 2 TgMIC1 TgMIC1 NNP cord-355239-fc52dn3v 169 3 ) ) -RRB- cord-355239-fc52dn3v 169 4 forms form VBZ cord-355239-fc52dn3v 169 5 a a DT cord-355239-fc52dn3v 169 6 macromolecular macromolecular JJ cord-355239-fc52dn3v 169 7 complex complex NN cord-355239-fc52dn3v 169 8 with with IN cord-355239-fc52dn3v 169 9 TgMIC4 tgmic4 NN cord-355239-fc52dn3v 169 10 and and CC cord-355239-fc52dn3v 169 11 TgMIC6 tgmic6 NN cord-355239-fc52dn3v 169 12 . . . cord-355239-fc52dn3v 170 1 Single single JJ cord-355239-fc52dn3v 170 2 deletion deletion NN cord-355239-fc52dn3v 170 3 of of IN cord-355239-fc52dn3v 170 4 the the DT cord-355239-fc52dn3v 170 5 TgMIC1 TgMIC1 NNP cord-355239-fc52dn3v 170 6 gene gene NN cord-355239-fc52dn3v 170 7 significantly significantly RB cord-355239-fc52dn3v 170 8 decreases decrease VBZ cord-355239-fc52dn3v 170 9 the the DT cord-355239-fc52dn3v 170 10 invasion invasion NN cord-355239-fc52dn3v 170 11 of of IN cord-355239-fc52dn3v 170 12 host host NN cord-355239-fc52dn3v 170 13 cells cell NNS cord-355239-fc52dn3v 170 14 , , , cord-355239-fc52dn3v 170 15 suggesting suggest VBG cord-355239-fc52dn3v 170 16 an an DT cord-355239-fc52dn3v 170 17 essential essential JJ cord-355239-fc52dn3v 170 18 role role NN cord-355239-fc52dn3v 170 19 for for IN cord-355239-fc52dn3v 170 20 TgMIC1 TgMIC1 NNP cord-355239-fc52dn3v 170 21 in in IN cord-355239-fc52dn3v 170 22 host host NN cord-355239-fc52dn3v 170 23 cell cell NN cord-355239-fc52dn3v 170 24 attachment attachment NN cord-355239-fc52dn3v 170 25 and and CC cord-355239-fc52dn3v 170 26 invasion invasion NN cord-355239-fc52dn3v 170 27 of of IN cord-355239-fc52dn3v 170 28 T. t. NN cord-355239-fc52dn3v 170 29 gondii gondii NNP cord-355239-fc52dn3v 170 30 [ [ -LRB- cord-355239-fc52dn3v 170 31 36 36 CD cord-355239-fc52dn3v 170 32 ] ] -RRB- cord-355239-fc52dn3v 170 33 . . . cord-355239-fc52dn3v 171 1 Structural structural JJ cord-355239-fc52dn3v 171 2 analysis analysis NN cord-355239-fc52dn3v 171 3 of of IN cord-355239-fc52dn3v 171 4 TgMIC1 TgMIC1 NNP cord-355239-fc52dn3v 171 5 revealed reveal VBD cord-355239-fc52dn3v 171 6 a a DT cord-355239-fc52dn3v 171 7 novel novel JJ cord-355239-fc52dn3v 171 8 cellbinding cellbinding NN cord-355239-fc52dn3v 171 9 motif motif NN cord-355239-fc52dn3v 171 10 called call VBN cord-355239-fc52dn3v 171 11 microneme microneme NNP cord-355239-fc52dn3v 171 12 adhesive adhesive NN cord-355239-fc52dn3v 171 13 repeat repeat NN cord-355239-fc52dn3v 171 14 region region NN cord-355239-fc52dn3v 171 15 ( ( -LRB- cord-355239-fc52dn3v 171 16 MARR MARR NNP cord-355239-fc52dn3v 171 17 ) ) -RRB- cord-355239-fc52dn3v 171 18 , , , cord-355239-fc52dn3v 171 19 which which WDT cord-355239-fc52dn3v 171 20 provides provide VBZ cord-355239-fc52dn3v 171 21 a a DT cord-355239-fc52dn3v 171 22 specialized specialized JJ cord-355239-fc52dn3v 171 23 structure structure NN cord-355239-fc52dn3v 171 24 for for IN cord-355239-fc52dn3v 171 25 glycan glycan NN cord-355239-fc52dn3v 171 26 discrimination discrimination NN cord-355239-fc52dn3v 171 27 [ [ -LRB- cord-355239-fc52dn3v 171 28 37 37 CD cord-355239-fc52dn3v 171 29 ] ] -RRB- cord-355239-fc52dn3v 171 30 . . . cord-355239-fc52dn3v 172 1 Carbohydrate carbohydrate NN cord-355239-fc52dn3v 172 2 microarray microarray NN cord-355239-fc52dn3v 172 3 analyses analysis NNS cord-355239-fc52dn3v 172 4 showed show VBD cord-355239-fc52dn3v 172 5 that that IN cord-355239-fc52dn3v 172 6 TgMIC13 TgMIC13 NNP cord-355239-fc52dn3v 172 7 , , , cord-355239-fc52dn3v 172 8 TgMIC1 tgmic1 NN cord-355239-fc52dn3v 172 9 and and CC cord-355239-fc52dn3v 172 10 its -PRON- PRP$ cord-355239-fc52dn3v 172 11 homologue homologue NN cord-355239-fc52dn3v 172 12 Neospora Neospora NNP cord-355239-fc52dn3v 172 13 caninum caninum NN cord-355239-fc52dn3v 172 14 MIC1 MIC1 NNP cord-355239-fc52dn3v 172 15 share share VBP cord-355239-fc52dn3v 172 16 a a DT cord-355239-fc52dn3v 172 17 preference preference NN cord-355239-fc52dn3v 172 18 for for IN cord-355239-fc52dn3v 172 19 α2 α2 NNP cord-355239-fc52dn3v 172 20 - - : cord-355239-fc52dn3v 172 21 3-over 3-over CD cord-355239-fc52dn3v 172 22 α2 α2 NNP cord-355239-fc52dn3v 172 23 - - HYPH cord-355239-fc52dn3v 172 24 6-linked 6-linked CD cord-355239-fc52dn3v 172 25 sialyl sialyl NNP cord-355239-fc52dn3v 172 26 - - HYPH cord-355239-fc52dn3v 172 27 N n NN cord-355239-fc52dn3v 172 28 - - HYPH cord-355239-fc52dn3v 172 29 acetyllactosamine acetyllactosamine NN cord-355239-fc52dn3v 172 30 sequences sequence NNS cord-355239-fc52dn3v 172 31 [ [ -LRB- cord-355239-fc52dn3v 172 32 38 38 CD cord-355239-fc52dn3v 172 33 ] ] -RRB- cord-355239-fc52dn3v 172 34 . . . cord-355239-fc52dn3v 173 1 P104 P104 NNP cord-355239-fc52dn3v 173 2 , , , cord-355239-fc52dn3v 173 3 a a DT cord-355239-fc52dn3v 173 4 PAN PAN NNP cord-355239-fc52dn3v 173 5 / / SYM cord-355239-fc52dn3v 173 6 apple apple NN cord-355239-fc52dn3v 173 7 domain domain NN cord-355239-fc52dn3v 173 8 - - HYPH cord-355239-fc52dn3v 173 9 containing contain VBG cord-355239-fc52dn3v 173 10 protein protein NN cord-355239-fc52dn3v 173 11 expressed express VBN cord-355239-fc52dn3v 173 12 at at IN cord-355239-fc52dn3v 173 13 the the DT cord-355239-fc52dn3v 173 14 apical apical JJ cord-355239-fc52dn3v 173 15 end end NN cord-355239-fc52dn3v 173 16 of of IN cord-355239-fc52dn3v 173 17 the the DT cord-355239-fc52dn3v 173 18 extracellular extracellular JJ cord-355239-fc52dn3v 173 19 parasite parasite NN cord-355239-fc52dn3v 173 20 , , , cord-355239-fc52dn3v 173 21 functions function VBZ cord-355239-fc52dn3v 173 22 as as IN cord-355239-fc52dn3v 173 23 a a DT cord-355239-fc52dn3v 173 24 ligand ligand NN cord-355239-fc52dn3v 173 25 in in IN cord-355239-fc52dn3v 173 26 the the DT cord-355239-fc52dn3v 173 27 attachment attachment NN cord-355239-fc52dn3v 173 28 of of IN cord-355239-fc52dn3v 173 29 T. t. NN cord-355239-fc52dn3v 173 30 gondii gondii NN cord-355239-fc52dn3v 173 31 to to IN cord-355239-fc52dn3v 173 32 chondroitin chondroitin NN cord-355239-fc52dn3v 173 33 sulfate sulfate NN cord-355239-fc52dn3v 173 34 and and CC cord-355239-fc52dn3v 173 35 other other JJ cord-355239-fc52dn3v 173 36 receptors receptor NNS cord-355239-fc52dn3v 173 37 on on IN cord-355239-fc52dn3v 173 38 the the DT cord-355239-fc52dn3v 173 39 host host NN cord-355239-fc52dn3v 173 40 cell cell NN cord-355239-fc52dn3v 173 41 , , , cord-355239-fc52dn3v 173 42 facilitating facilitate VBG cord-355239-fc52dn3v 173 43 invasion invasion NN cord-355239-fc52dn3v 173 44 by by IN cord-355239-fc52dn3v 173 45 the the DT cord-355239-fc52dn3v 173 46 parasite parasite NN cord-355239-fc52dn3v 173 47 ( ( -LRB- cord-355239-fc52dn3v 173 48 Fig Fig NNP cord-355239-fc52dn3v 173 49 . . . cord-355239-fc52dn3v 173 50 4 4 LS cord-355239-fc52dn3v 173 51 ) ) -RRB- cord-355239-fc52dn3v 173 52 [ [ -LRB- cord-355239-fc52dn3v 173 53 39 39 CD cord-355239-fc52dn3v 173 54 ] ] -RRB- cord-355239-fc52dn3v 173 55 . . . cord-355239-fc52dn3v 174 1 T. T. NNP cord-355239-fc52dn3v 174 2 gondii gondii NNP cord-355239-fc52dn3v 174 3 display display NN cord-355239-fc52dn3v 174 4 GPI GPI NNP cord-355239-fc52dn3v 174 5 - - HYPH cord-355239-fc52dn3v 174 6 anchored anchor VBN cord-355239-fc52dn3v 174 7 surface surface NN cord-355239-fc52dn3v 174 8 proteins protein NNS cord-355239-fc52dn3v 174 9 identified identify VBN cord-355239-fc52dn3v 174 10 as as IN cord-355239-fc52dn3v 174 11 surface surface NN cord-355239-fc52dn3v 174 12 antigen antigen NN cord-355239-fc52dn3v 174 13 glycoprotein glycoprotein NN cord-355239-fc52dn3v 174 14 ( ( -LRB- cord-355239-fc52dn3v 174 15 SAG SAG NNP cord-355239-fc52dn3v 174 16 ) ) -RRB- cord-355239-fc52dn3v 174 17 1 1 CD cord-355239-fc52dn3v 174 18 related relate VBN cord-355239-fc52dn3v 174 19 sequences sequence NNS cord-355239-fc52dn3v 174 20 ( ( -LRB- cord-355239-fc52dn3v 174 21 SRS SRS NNP cord-355239-fc52dn3v 174 22 ) ) -RRB- cord-355239-fc52dn3v 174 23 [ [ -LRB- cord-355239-fc52dn3v 174 24 40 40 CD cord-355239-fc52dn3v 174 25 ] ] -RRB- cord-355239-fc52dn3v 174 26 . . . cord-355239-fc52dn3v 175 1 SAG1 SAG1 NNP cord-355239-fc52dn3v 175 2 , , , cord-355239-fc52dn3v 175 3 SAG2A SAG2A NNP cord-355239-fc52dn3v 175 4 and and CC cord-355239-fc52dn3v 175 5 SAG3 SAG3 NNP cord-355239-fc52dn3v 175 6 have have VBP cord-355239-fc52dn3v 175 7 some some DT cord-355239-fc52dn3v 175 8 capacity capacity NN cord-355239-fc52dn3v 175 9 for for IN cord-355239-fc52dn3v 175 10 host host NN cord-355239-fc52dn3v 175 11 cell cell NN cord-355239-fc52dn3v 175 12 attachment attachment NN cord-355239-fc52dn3v 175 13 through through IN cord-355239-fc52dn3v 175 14 glycan glycan NN cord-355239-fc52dn3v 175 15 recognition recognition NN cord-355239-fc52dn3v 175 16 ( ( -LRB- cord-355239-fc52dn3v 175 17 Fig Fig NNP cord-355239-fc52dn3v 175 18 . . . cord-355239-fc52dn3v 175 19 4 4 LS cord-355239-fc52dn3v 175 20 ) ) -RRB- cord-355239-fc52dn3v 175 21 [ [ -LRB- cord-355239-fc52dn3v 175 22 41 41 CD cord-355239-fc52dn3v 175 23 , , , cord-355239-fc52dn3v 175 24 42 42 CD cord-355239-fc52dn3v 175 25 ] ] -RRB- cord-355239-fc52dn3v 175 26 . . . cord-355239-fc52dn3v 176 1 SAG3 SAG3 NNP cord-355239-fc52dn3v 176 2 binds bind VBZ cord-355239-fc52dn3v 176 3 to to IN cord-355239-fc52dn3v 176 4 sulfated sulfated JJ cord-355239-fc52dn3v 176 5 proteoglycans proteoglycan NNS cord-355239-fc52dn3v 176 6 such such JJ cord-355239-fc52dn3v 176 7 as as IN cord-355239-fc52dn3v 176 8 heparin heparin NN cord-355239-fc52dn3v 176 9 , , , cord-355239-fc52dn3v 176 10 fucoidan fucoidan NNP cord-355239-fc52dn3v 176 11 , , , cord-355239-fc52dn3v 176 12 and and CC cord-355239-fc52dn3v 176 13 dextran dextran NN cord-355239-fc52dn3v 176 14 sulfate sulfate NN cord-355239-fc52dn3v 176 15 with with IN cord-355239-fc52dn3v 176 16 high high JJ cord-355239-fc52dn3v 176 17 affinity affinity NN cord-355239-fc52dn3v 176 18 [ [ -LRB- cord-355239-fc52dn3v 176 19 43 43 CD cord-355239-fc52dn3v 176 20 ] ] -RRB- cord-355239-fc52dn3v 176 21 . . . cord-355239-fc52dn3v 177 1 Targeted target VBN cord-355239-fc52dn3v 177 2 disruption disruption NN cord-355239-fc52dn3v 177 3 of of IN cord-355239-fc52dn3v 177 4 SAG3 SAG3 NNP cord-355239-fc52dn3v 177 5 significantly significantly RB cord-355239-fc52dn3v 177 6 reduces reduce VBZ cord-355239-fc52dn3v 177 7 host host NN cord-355239-fc52dn3v 177 8 cell cell NN cord-355239-fc52dn3v 177 9 binding binding NN cord-355239-fc52dn3v 177 10 of of IN cord-355239-fc52dn3v 177 11 T. t. NN cord-355239-fc52dn3v 177 12 gondii gondii NNP cord-355239-fc52dn3v 177 13 [ [ -LRB- cord-355239-fc52dn3v 177 14 41 41 CD cord-355239-fc52dn3v 177 15 ] ] -RRB- cord-355239-fc52dn3v 177 16 . . . cord-355239-fc52dn3v 178 1 E. E. NNP cord-355239-fc52dn3v 178 2 histolytica histolytica NNP cord-355239-fc52dn3v 178 3 fibronectin fibronectin NN cord-355239-fc52dn3v 178 4 receptor receptor NN cord-355239-fc52dn3v 178 5 ( ( -LRB- cord-355239-fc52dn3v 178 6 EhFNR EhFNR NNP cord-355239-fc52dn3v 178 7 ) ) -RRB- cord-355239-fc52dn3v 178 8 shows show VBZ cord-355239-fc52dn3v 178 9 99 99 CD cord-355239-fc52dn3v 178 10 % % NN cord-355239-fc52dn3v 178 11 homology homology NN cord-355239-fc52dn3v 178 12 to to IN cord-355239-fc52dn3v 178 13 the the DT cord-355239-fc52dn3v 178 14 intermediate intermediate JJ cord-355239-fc52dn3v 178 15 subunit-2 subunit-2 NN cord-355239-fc52dn3v 178 16 of of IN cord-355239-fc52dn3v 178 17 the the DT cord-355239-fc52dn3v 178 18 Gal/ Gal/ NNP cord-355239-fc52dn3v 178 19 GalNAc galnac NN cord-355239-fc52dn3v 178 20 - - HYPH cord-355239-fc52dn3v 178 21 specific specific JJ cord-355239-fc52dn3v 178 22 lectin lectin NN cord-355239-fc52dn3v 178 23 [ [ -LRB- cord-355239-fc52dn3v 178 24 44 44 CD cord-355239-fc52dn3v 178 25 ] ] -RRB- cord-355239-fc52dn3v 178 26 . . . cord-355239-fc52dn3v 179 1 Electron electron NN cord-355239-fc52dn3v 179 2 microscopy microscopy NN cord-355239-fc52dn3v 179 3 revealed reveal VBD cord-355239-fc52dn3v 179 4 the the DT cord-355239-fc52dn3v 179 5 close close JJ cord-355239-fc52dn3v 179 6 association association NN cord-355239-fc52dn3v 179 7 of of IN cord-355239-fc52dn3v 179 8 a a DT cord-355239-fc52dn3v 179 9 purified purify VBN cord-355239-fc52dn3v 179 10 EhFNR EhFNR NNP cord-355239-fc52dn3v 179 11 complex complex NN cord-355239-fc52dn3v 179 12 to to IN cord-355239-fc52dn3v 179 13 adhesion adhesion NN cord-355239-fc52dn3v 179 14 plates plate NNS cord-355239-fc52dn3v 179 15 and and CC cord-355239-fc52dn3v 179 16 phagocytic phagocytic JJ cord-355239-fc52dn3v 179 17 invaginations invagination NNS cord-355239-fc52dn3v 179 18 . . . cord-355239-fc52dn3v 180 1 Lipid lipid NN cord-355239-fc52dn3v 180 2 rafts raft NNS cord-355239-fc52dn3v 180 3 participate participate VBP cord-355239-fc52dn3v 180 4 in in IN cord-355239-fc52dn3v 180 5 interactions interaction NNS cord-355239-fc52dn3v 180 6 between between IN cord-355239-fc52dn3v 180 7 E. E. NNP cord-355239-fc52dn3v 180 8 histolytica histolytica NNP cord-355239-fc52dn3v 180 9 and and CC cord-355239-fc52dn3v 180 10 the the DT cord-355239-fc52dn3v 180 11 host host NN cord-355239-fc52dn3v 180 12 extracellular extracellular JJ cord-355239-fc52dn3v 180 13 matrix matrix NN cord-355239-fc52dn3v 180 14 , , , cord-355239-fc52dn3v 180 15 and and CC cord-355239-fc52dn3v 180 16 it -PRON- PRP cord-355239-fc52dn3v 180 17 appears appear VBZ cord-355239-fc52dn3v 180 18 that that IN cord-355239-fc52dn3v 180 19 raft raft NN cord-355239-fc52dn3v 180 20 - - HYPH cord-355239-fc52dn3v 180 21 associated associate VBN cord-355239-fc52dn3v 180 22 Gal/ Gal/ NNP cord-355239-fc52dn3v 180 23 GalNAc galnac NN cord-355239-fc52dn3v 180 24 lectin lectin NN cord-355239-fc52dn3v 180 25 serves serve VBZ cord-355239-fc52dn3v 180 26 as as IN cord-355239-fc52dn3v 180 27 a a DT cord-355239-fc52dn3v 180 28 collagen collagen NN cord-355239-fc52dn3v 180 29 receptor receptor NN cord-355239-fc52dn3v 180 30 [ [ -LRB- cord-355239-fc52dn3v 180 31 45 45 CD cord-355239-fc52dn3v 180 32 ] ] -RRB- cord-355239-fc52dn3v 180 33 . . . cord-355239-fc52dn3v 181 1 Cryptosporidium cryptosporidium NN cord-355239-fc52dn3v 181 2 parvum parvum NN cord-355239-fc52dn3v 181 3 surface surface VBP cord-355239-fc52dn3v 181 4 receptors receptor NNS cord-355239-fc52dn3v 181 5 , , , cord-355239-fc52dn3v 181 6 GP900 GP900 NNP cord-355239-fc52dn3v 181 7 and and CC cord-355239-fc52dn3v 181 8 proteolytic proteolytic JJ cord-355239-fc52dn3v 181 9 fragments fragment NNS cord-355239-fc52dn3v 181 10 of of IN cord-355239-fc52dn3v 181 11 the the DT cord-355239-fc52dn3v 181 12 60-kDa 60-kda CD cord-355239-fc52dn3v 181 13 precursor precursor NN cord-355239-fc52dn3v 181 14 protein protein NN cord-355239-fc52dn3v 181 15 , , , cord-355239-fc52dn3v 181 16 GP40 GP40 NNP cord-355239-fc52dn3v 181 17 and and CC cord-355239-fc52dn3v 181 18 GP15 GP15 NNP cord-355239-fc52dn3v 181 19 , , , cord-355239-fc52dn3v 181 20 are be VBP cord-355239-fc52dn3v 181 21 characterized characterize VBN cord-355239-fc52dn3v 181 22 as as IN cord-355239-fc52dn3v 181 23 mucin mucin NN cord-355239-fc52dn3v 181 24 - - HYPH cord-355239-fc52dn3v 181 25 like like JJ cord-355239-fc52dn3v 181 26 and and CC cord-355239-fc52dn3v 181 27 heavily heavily RB cord-355239-fc52dn3v 181 28 O o NN cord-355239-fc52dn3v 181 29 - - HYPH cord-355239-fc52dn3v 181 30 glycosylated glycosylate VBN cord-355239-fc52dn3v 181 31 proteins protein NNS cord-355239-fc52dn3v 181 32 [ [ -LRB- cord-355239-fc52dn3v 181 33 46 46 CD cord-355239-fc52dn3v 181 34 ] ] -RRB- cord-355239-fc52dn3v 182 1 [ [ -LRB- cord-355239-fc52dn3v 182 2 47 47 CD cord-355239-fc52dn3v 182 3 ] ] -RRB- cord-355239-fc52dn3v 182 4 [ [ -LRB- cord-355239-fc52dn3v 182 5 48 48 CD cord-355239-fc52dn3v 182 6 ] ] -RRB- cord-355239-fc52dn3v 182 7 . . . cord-355239-fc52dn3v 183 1 The the DT cord-355239-fc52dn3v 183 2 GP900 GP900 NNP cord-355239-fc52dn3v 183 3 and and CC cord-355239-fc52dn3v 183 4 GP40 GP40 NNP cord-355239-fc52dn3v 183 5 of of IN cord-355239-fc52dn3v 183 6 sporozoites sporozoite NNS cord-355239-fc52dn3v 183 7 and and CC cord-355239-fc52dn3v 183 8 merozoites merozoite NNS cord-355239-fc52dn3v 183 9 have have VBP cord-355239-fc52dn3v 183 10 carbohydrate carbohydrate NN cord-355239-fc52dn3v 183 11 residues residue NNS cord-355239-fc52dn3v 183 12 that that WDT cord-355239-fc52dn3v 183 13 are be VBP cord-355239-fc52dn3v 183 14 bound bind VBN cord-355239-fc52dn3v 183 15 by by IN cord-355239-fc52dn3v 183 16 αGalNAc αGalNAc NNP cord-355239-fc52dn3v 183 17 - - HYPH cord-355239-fc52dn3v 183 18 specific specific JJ cord-355239-fc52dn3v 183 19 lectins lectin NNS cord-355239-fc52dn3v 183 20 , , , cord-355239-fc52dn3v 183 21 suggesting suggest VBG cord-355239-fc52dn3v 183 22 that that IN cord-355239-fc52dn3v 183 23 αGalNAc αGalNAc NNP cord-355239-fc52dn3v 183 24 residues residue NNS cord-355239-fc52dn3v 183 25 are be VBP cord-355239-fc52dn3v 183 26 involved involve VBN cord-355239-fc52dn3v 183 27 in in IN cord-355239-fc52dn3v 183 28 the the DT cord-355239-fc52dn3v 183 29 attachment attachment NN cord-355239-fc52dn3v 183 30 of of IN cord-355239-fc52dn3v 183 31 parasites parasite NNS cord-355239-fc52dn3v 183 32 to to TO cord-355239-fc52dn3v 183 33 host host VB cord-355239-fc52dn3v 183 34 cells cell NNS cord-355239-fc52dn3v 183 35 via via IN cord-355239-fc52dn3v 183 36 adherence adherence NN cord-355239-fc52dn3v 183 37 to to IN cord-355239-fc52dn3v 183 38 internal internal JJ cord-355239-fc52dn3v 183 39 mucus mucus NN cord-355239-fc52dn3v 183 40 . . . cord-355239-fc52dn3v 184 1 Apicomplexan Apicomplexan NNP cord-355239-fc52dn3v 184 2 protozoan protozoan NN cord-355239-fc52dn3v 184 3 parasites parasite NNS cord-355239-fc52dn3v 184 4 also also RB cord-355239-fc52dn3v 184 5 induce induce VBP cord-355239-fc52dn3v 184 6 host host NN cord-355239-fc52dn3v 184 7 innate innate JJ cord-355239-fc52dn3v 184 8 immune immune JJ cord-355239-fc52dn3v 184 9 responses response NNS cord-355239-fc52dn3v 184 10 via via IN cord-355239-fc52dn3v 184 11 the the DT cord-355239-fc52dn3v 184 12 carbohydrate carbohydrate NN cord-355239-fc52dn3v 184 13 molecules molecule NNS cord-355239-fc52dn3v 184 14 present present JJ cord-355239-fc52dn3v 184 15 on on IN cord-355239-fc52dn3v 184 16 their -PRON- PRP$ cord-355239-fc52dn3v 184 17 cell cell NN cord-355239-fc52dn3v 184 18 surface surface NN cord-355239-fc52dn3v 184 19 [ [ -LRB- cord-355239-fc52dn3v 184 20 49 49 CD cord-355239-fc52dn3v 184 21 ] ] -RRB- cord-355239-fc52dn3v 184 22 . . . cord-355239-fc52dn3v 185 1 Glycosylphosphatidylinositol Glycosylphosphatidylinositol NNP cord-355239-fc52dn3v 185 2 ( ( -LRB- cord-355239-fc52dn3v 185 3 GPI GPI NNP cord-355239-fc52dn3v 185 4 ) ) -RRB- cord-355239-fc52dn3v 185 5 protein protein NN cord-355239-fc52dn3v 185 6 anchors anchor NNS cord-355239-fc52dn3v 185 7 are be VBP cord-355239-fc52dn3v 185 8 abundant abundant JJ cord-355239-fc52dn3v 185 9 in in IN cord-355239-fc52dn3v 185 10 the the DT cord-355239-fc52dn3v 185 11 membranes membrane NNS cord-355239-fc52dn3v 185 12 of of IN cord-355239-fc52dn3v 185 13 tachyzoites tachyzoite NNS cord-355239-fc52dn3v 185 14 and and CC cord-355239-fc52dn3v 185 15 other other JJ cord-355239-fc52dn3v 185 16 apicomplexan apicomplexan NNP cord-355239-fc52dn3v 185 17 protozoan protozoan NN cord-355239-fc52dn3v 185 18 parasites parasite NNS cord-355239-fc52dn3v 185 19 including include VBG cord-355239-fc52dn3v 185 20 Trypanosoma Trypanosoma NNP cord-355239-fc52dn3v 185 21 , , , cord-355239-fc52dn3v 185 22 Leishmania Leishmania NNP cord-355239-fc52dn3v 185 23 and and CC cord-355239-fc52dn3v 185 24 Plasmodium Plasmodium NNP cord-355239-fc52dn3v 185 25 spp spp NNS cord-355239-fc52dn3v 185 26 . . . cord-355239-fc52dn3v 186 1 , , , cord-355239-fc52dn3v 186 2 where where WRB cord-355239-fc52dn3v 186 3 they -PRON- PRP cord-355239-fc52dn3v 186 4 can can MD cord-355239-fc52dn3v 186 5 serve serve VB cord-355239-fc52dn3v 186 6 as as IN cord-355239-fc52dn3v 186 7 ligands ligand NNS cord-355239-fc52dn3v 186 8 for for IN cord-355239-fc52dn3v 186 9 innate innate JJ cord-355239-fc52dn3v 186 10 recognition recognition NN cord-355239-fc52dn3v 186 11 [ [ -LRB- cord-355239-fc52dn3v 186 12 50 50 CD cord-355239-fc52dn3v 186 13 ] ] -RRB- cord-355239-fc52dn3v 186 14 . . . cord-355239-fc52dn3v 187 1 The the DT cord-355239-fc52dn3v 187 2 GPI GPI NNP cord-355239-fc52dn3v 187 3 moieties moiety NNS cord-355239-fc52dn3v 187 4 of of IN cord-355239-fc52dn3v 187 5 T. T. NNP cord-355239-fc52dn3v 187 6 cruzi cruzi NNP cord-355239-fc52dn3v 187 7 and and CC cord-355239-fc52dn3v 187 8 P. P. NNP cord-355239-fc52dn3v 187 9 falciparum falciparum NNS cord-355239-fc52dn3v 187 10 were be VBD cord-355239-fc52dn3v 187 11 found find VBN cord-355239-fc52dn3v 187 12 to to TO cord-355239-fc52dn3v 187 13 be be VB cord-355239-fc52dn3v 187 14 TLR2 TLR2 NNP cord-355239-fc52dn3v 187 15 ligands ligand NNS cord-355239-fc52dn3v 187 16 [ [ -LRB- cord-355239-fc52dn3v 187 17 51 51 CD cord-355239-fc52dn3v 187 18 , , , cord-355239-fc52dn3v 187 19 52 52 CD cord-355239-fc52dn3v 187 20 ] ] -RRB- cord-355239-fc52dn3v 187 21 , , , cord-355239-fc52dn3v 187 22 and and CC cord-355239-fc52dn3v 187 23 T. t. NN cord-355239-fc52dn3v 187 24 gondii gondii NNP cord-355239-fc52dn3v 187 25 both both DT cord-355239-fc52dn3v 187 26 stimulate stimulate VBP cord-355239-fc52dn3v 187 27 cytokine cytokine NN cord-355239-fc52dn3v 187 28 production production NN cord-355239-fc52dn3v 187 29 in in IN cord-355239-fc52dn3v 187 30 macrophages macrophage NNS cord-355239-fc52dn3v 187 31 and and CC cord-355239-fc52dn3v 187 32 serve serve VBP cord-355239-fc52dn3v 187 33 as as IN cord-355239-fc52dn3v 187 34 TLR2 TLR2 NNP cord-355239-fc52dn3v 187 35 as as RB cord-355239-fc52dn3v 187 36 well well RB cord-355239-fc52dn3v 187 37 as as IN cord-355239-fc52dn3v 187 38 TLR4 TLR4 NNP cord-355239-fc52dn3v 187 39 agonists agonist NNS cord-355239-fc52dn3v 187 40 . . . cord-355239-fc52dn3v 188 1 In in IN cord-355239-fc52dn3v 188 2 the the DT cord-355239-fc52dn3v 188 3 case case NN cord-355239-fc52dn3v 188 4 of of IN cord-355239-fc52dn3v 188 5 T. t. NN cord-355239-fc52dn3v 188 6 gondii gondii NNP cord-355239-fc52dn3v 188 7 , , , cord-355239-fc52dn3v 188 8 GPI GPI NNP cord-355239-fc52dn3v 188 9 induces induce VBZ cord-355239-fc52dn3v 188 10 TNF TNF NNP cord-355239-fc52dn3v 188 11 - - HYPH cord-355239-fc52dn3v 188 12 α α NN cord-355239-fc52dn3v 188 13 production production NN cord-355239-fc52dn3v 188 14 in in IN cord-355239-fc52dn3v 188 15 macrophages macrophage NNS cord-355239-fc52dn3v 188 16 through through IN cord-355239-fc52dn3v 188 17 the the DT cord-355239-fc52dn3v 188 18 activation activation NN cord-355239-fc52dn3v 188 19 of of IN cord-355239-fc52dn3v 188 20 the the DT cord-355239-fc52dn3v 188 21 transcription transcription NN cord-355239-fc52dn3v 188 22 factor factor NN cord-355239-fc52dn3v 188 23 NF nf NN cord-355239-fc52dn3v 188 24 - - HYPH cord-355239-fc52dn3v 188 25 κB κB NNP cord-355239-fc52dn3v 188 26 [ [ -LRB- cord-355239-fc52dn3v 188 27 53 53 CD cord-355239-fc52dn3v 188 28 ] ] -RRB- cord-355239-fc52dn3v 188 29 . . . cord-355239-fc52dn3v 189 1 Carbohydrates carbohydrate NNS cord-355239-fc52dn3v 189 2 serve serve VBP cord-355239-fc52dn3v 189 3 as as IN cord-355239-fc52dn3v 189 4 receptors receptor NNS cord-355239-fc52dn3v 189 5 for for IN cord-355239-fc52dn3v 189 6 infections infection NNS cord-355239-fc52dn3v 189 7 by by IN cord-355239-fc52dn3v 189 8 viruses virus NNS cord-355239-fc52dn3v 189 9 , , , cord-355239-fc52dn3v 189 10 bacteria bacteria NNS cord-355239-fc52dn3v 189 11 and and CC cord-355239-fc52dn3v 189 12 protozoa protozoan NNS cord-355239-fc52dn3v 189 13 , , , cord-355239-fc52dn3v 189 14 but but CC cord-355239-fc52dn3v 189 15 the the DT cord-355239-fc52dn3v 189 16 usage usage NN cord-355239-fc52dn3v 189 17 of of IN cord-355239-fc52dn3v 189 18 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 189 19 by by IN cord-355239-fc52dn3v 189 20 these these DT cord-355239-fc52dn3v 189 21 microbes microbe NNS cord-355239-fc52dn3v 189 22 varies vary VBZ cord-355239-fc52dn3v 189 23 depending depend VBG cord-355239-fc52dn3v 189 24 on on IN cord-355239-fc52dn3v 189 25 the the DT cord-355239-fc52dn3v 189 26 microbe microbe NN cord-355239-fc52dn3v 189 27 . . . cord-355239-fc52dn3v 190 1 At at IN cord-355239-fc52dn3v 190 2 the the DT cord-355239-fc52dn3v 190 3 initial initial JJ cord-355239-fc52dn3v 190 4 infection infection NN cord-355239-fc52dn3v 190 5 step step NN cord-355239-fc52dn3v 190 6 , , , cord-355239-fc52dn3v 190 7 these these DT cord-355239-fc52dn3v 190 8 organisms organism NNS cord-355239-fc52dn3v 190 9 do do VBP cord-355239-fc52dn3v 190 10 not not RB cord-355239-fc52dn3v 190 11 simply simply RB cord-355239-fc52dn3v 190 12 utilize utilize VB cord-355239-fc52dn3v 190 13 the the DT cord-355239-fc52dn3v 190 14 electrical electrical JJ cord-355239-fc52dn3v 190 15 forces force NNS cord-355239-fc52dn3v 190 16 created create VBN cord-355239-fc52dn3v 190 17 by by IN cord-355239-fc52dn3v 190 18 the the DT cord-355239-fc52dn3v 190 19 positive positive JJ cord-355239-fc52dn3v 190 20 and and CC cord-355239-fc52dn3v 190 21 negative negative JJ cord-355239-fc52dn3v 190 22 charges charge NNS cord-355239-fc52dn3v 190 23 of of IN cord-355239-fc52dn3v 190 24 the the DT cord-355239-fc52dn3v 190 25 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 190 26 ; ; : cord-355239-fc52dn3v 190 27 rather rather RB cord-355239-fc52dn3v 190 28 , , , cord-355239-fc52dn3v 190 29 they -PRON- PRP cord-355239-fc52dn3v 190 30 make make VBP cord-355239-fc52dn3v 190 31 use use NN cord-355239-fc52dn3v 190 32 of of IN cord-355239-fc52dn3v 190 33 other other JJ cord-355239-fc52dn3v 190 34 systems system NNS cord-355239-fc52dn3v 190 35 in in IN cord-355239-fc52dn3v 190 36 certain certain JJ cord-355239-fc52dn3v 190 37 instances instance NNS cord-355239-fc52dn3v 190 38 . . . cord-355239-fc52dn3v 191 1 One one CD cord-355239-fc52dn3v 191 2 similarity similarity NN cord-355239-fc52dn3v 191 3 shared share VBN cord-355239-fc52dn3v 191 4 by by IN cord-355239-fc52dn3v 191 5 all all DT cord-355239-fc52dn3v 191 6 three three CD cord-355239-fc52dn3v 191 7 microbes microbe NNS cord-355239-fc52dn3v 191 8 regarding regard VBG cord-355239-fc52dn3v 191 9 their -PRON- PRP$ cord-355239-fc52dn3v 191 10 interactions interaction NNS cord-355239-fc52dn3v 191 11 with with IN cord-355239-fc52dn3v 191 12 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 191 13 , , , cord-355239-fc52dn3v 191 14 however however RB cord-355239-fc52dn3v 191 15 , , , cord-355239-fc52dn3v 191 16 is be VBZ cord-355239-fc52dn3v 191 17 that that DT cord-355239-fc52dn3v 191 18 heparan heparan NN cord-355239-fc52dn3v 191 19 sulfate sulfate NN cord-355239-fc52dn3v 191 20 plays play VBZ cord-355239-fc52dn3v 191 21 an an DT cord-355239-fc52dn3v 191 22 important important JJ cord-355239-fc52dn3v 191 23 role role NN cord-355239-fc52dn3v 191 24 at at IN cord-355239-fc52dn3v 191 25 entry entry NN cord-355239-fc52dn3v 191 26 or or CC cord-355239-fc52dn3v 191 27 invasion invasion NN cord-355239-fc52dn3v 191 28 of of IN cord-355239-fc52dn3v 191 29 the the DT cord-355239-fc52dn3v 191 30 host host NN cord-355239-fc52dn3v 191 31 cell cell NN cord-355239-fc52dn3v 191 32 . . . cord-355239-fc52dn3v 192 1 Blood blood NN cord-355239-fc52dn3v 192 2 group group NN cord-355239-fc52dn3v 192 3 antigen antigen NN cord-355239-fc52dn3v 192 4 oligosaccharides oligosaccharide NNS cord-355239-fc52dn3v 192 5 are be VBP cord-355239-fc52dn3v 192 6 highly highly RB cord-355239-fc52dn3v 192 7 expressed express VBN cord-355239-fc52dn3v 192 8 in in IN cord-355239-fc52dn3v 192 9 the the DT cord-355239-fc52dn3v 192 10 gastrointestinal gastrointestinal JJ cord-355239-fc52dn3v 192 11 epithelium epithelium NN cord-355239-fc52dn3v 192 12 [ [ -LRB- cord-355239-fc52dn3v 192 13 54 54 CD cord-355239-fc52dn3v 192 14 ] ] -RRB- cord-355239-fc52dn3v 192 15 . . . cord-355239-fc52dn3v 193 1 However however RB cord-355239-fc52dn3v 193 2 , , , cord-355239-fc52dn3v 193 3 there there EX cord-355239-fc52dn3v 193 4 are be VBP cord-355239-fc52dn3v 193 5 individual individual JJ cord-355239-fc52dn3v 193 6 differences difference NNS cord-355239-fc52dn3v 193 7 in in IN cord-355239-fc52dn3v 193 8 terms term NNS cord-355239-fc52dn3v 193 9 of of IN cord-355239-fc52dn3v 193 10 the the DT cord-355239-fc52dn3v 193 11 presence presence NN cord-355239-fc52dn3v 193 12 of of IN cord-355239-fc52dn3v 193 13 these these DT cord-355239-fc52dn3v 193 14 antigens antigen NNS cord-355239-fc52dn3v 193 15 . . . cord-355239-fc52dn3v 194 1 In in IN cord-355239-fc52dn3v 194 2 addition addition NN cord-355239-fc52dn3v 194 3 , , , cord-355239-fc52dn3v 194 4 there there EX cord-355239-fc52dn3v 194 5 are be VBP cord-355239-fc52dn3v 194 6 individual individual JJ cord-355239-fc52dn3v 194 7 differences difference NNS cord-355239-fc52dn3v 194 8 in in IN cord-355239-fc52dn3v 194 9 sensitivity sensitivity NN cord-355239-fc52dn3v 194 10 to to IN cord-355239-fc52dn3v 194 11 pathogens pathogen NNS cord-355239-fc52dn3v 194 12 that that WDT cord-355239-fc52dn3v 194 13 recognize recognize VBP cord-355239-fc52dn3v 194 14 and and CC cord-355239-fc52dn3v 194 15 bind bind VB cord-355239-fc52dn3v 194 16 to to IN cord-355239-fc52dn3v 194 17 blood blood NN cord-355239-fc52dn3v 194 18 group group NN cord-355239-fc52dn3v 194 19 antigens antigen NNS cord-355239-fc52dn3v 194 20 , , , cord-355239-fc52dn3v 194 21 such such JJ cord-355239-fc52dn3v 194 22 as as IN cord-355239-fc52dn3v 194 23 norovirus norovirus NN cord-355239-fc52dn3v 194 24 and and CC cord-355239-fc52dn3v 194 25 H. h. NN cord-355239-fc52dn3v 194 26 pylori pylori NN cord-355239-fc52dn3v 194 27 . . . cord-355239-fc52dn3v 195 1 These these DT cord-355239-fc52dn3v 195 2 individual individual JJ cord-355239-fc52dn3v 195 3 differences difference NNS cord-355239-fc52dn3v 195 4 in in IN cord-355239-fc52dn3v 195 5 antigen antigen NN cord-355239-fc52dn3v 195 6 expression expression NN cord-355239-fc52dn3v 195 7 profiles profile NNS cord-355239-fc52dn3v 195 8 benefit benefit VBP cord-355239-fc52dn3v 195 9 the the DT cord-355239-fc52dn3v 195 10 survival survival NN cord-355239-fc52dn3v 195 11 of of IN cord-355239-fc52dn3v 195 12 the the DT cord-355239-fc52dn3v 195 13 host host NN cord-355239-fc52dn3v 195 14 species specie NNS cord-355239-fc52dn3v 195 15 because because IN cord-355239-fc52dn3v 195 16 the the DT cord-355239-fc52dn3v 195 17 risk risk NN cord-355239-fc52dn3v 195 18 of of IN cord-355239-fc52dn3v 195 19 an an DT cord-355239-fc52dn3v 195 20 attack attack NN cord-355239-fc52dn3v 195 21 by by IN cord-355239-fc52dn3v 195 22 a a DT cord-355239-fc52dn3v 195 23 fatal fatal JJ cord-355239-fc52dn3v 195 24 virulent virulent JJ cord-355239-fc52dn3v 195 25 pathogen pathogen NN cord-355239-fc52dn3v 195 26 may may MD cord-355239-fc52dn3v 195 27 be be VB cord-355239-fc52dn3v 195 28 decreased decrease VBN cord-355239-fc52dn3v 195 29 to to TO cord-355239-fc52dn3v 195 30 avoid avoid VB cord-355239-fc52dn3v 195 31 extinction extinction NN cord-355239-fc52dn3v 195 32 . . . cord-355239-fc52dn3v 196 1 A a DT cord-355239-fc52dn3v 196 2 large large JJ cord-355239-fc52dn3v 196 3 array array NN cord-355239-fc52dn3v 196 4 of of IN cord-355239-fc52dn3v 196 5 glycoproteins glycoprotein NNS cord-355239-fc52dn3v 196 6 , , , cord-355239-fc52dn3v 196 7 glycolipids glycolipid NNS cord-355239-fc52dn3v 196 8 and and CC cord-355239-fc52dn3v 196 9 proteoglycans proteoglycan NNS cord-355239-fc52dn3v 196 10 decorate decorate VBP cord-355239-fc52dn3v 196 11 the the DT cord-355239-fc52dn3v 196 12 surface surface NN cord-355239-fc52dn3v 196 13 of of IN cord-355239-fc52dn3v 196 14 animal animal NN cord-355239-fc52dn3v 196 15 cells cell NNS cord-355239-fc52dn3v 196 16 . . . cord-355239-fc52dn3v 197 1 These these DT cord-355239-fc52dn3v 197 2 glycoconjugates glycoconjugate NNS cord-355239-fc52dn3v 197 3 mediate mediate VBP cord-355239-fc52dn3v 197 4 many many JJ cord-355239-fc52dn3v 197 5 fundamental fundamental JJ cord-355239-fc52dn3v 197 6 cellular cellular JJ cord-355239-fc52dn3v 197 7 processes process NNS cord-355239-fc52dn3v 197 8 , , , cord-355239-fc52dn3v 197 9 including include VBG cord-355239-fc52dn3v 197 10 cell cell NN cord-355239-fc52dn3v 197 11 - - HYPH cord-355239-fc52dn3v 197 12 cell cell NN cord-355239-fc52dn3v 197 13 and and CC cord-355239-fc52dn3v 197 14 cell cell NN cord-355239-fc52dn3v 197 15 - - HYPH cord-355239-fc52dn3v 197 16 matrix matrix NN cord-355239-fc52dn3v 197 17 adhesion adhesion NN cord-355239-fc52dn3v 197 18 , , , cord-355239-fc52dn3v 197 19 motility motility NN cord-355239-fc52dn3v 197 20 , , , cord-355239-fc52dn3v 197 21 growth growth NN cord-355239-fc52dn3v 197 22 and and CC cord-355239-fc52dn3v 197 23 signaling signal VBG cord-355239-fc52dn3v 197 24 [ [ -LRB- cord-355239-fc52dn3v 197 25 55 55 CD cord-355239-fc52dn3v 197 26 ] ] -RRB- cord-355239-fc52dn3v 197 27 [ [ -LRB- cord-355239-fc52dn3v 197 28 56 56 CD cord-355239-fc52dn3v 197 29 ] ] -RRB- cord-355239-fc52dn3v 197 30 [ [ -LRB- cord-355239-fc52dn3v 197 31 57 57 CD cord-355239-fc52dn3v 197 32 ] ] -RRB- cord-355239-fc52dn3v 197 33 . . . cord-355239-fc52dn3v 198 1 Mucosal Mucosal NNP cord-355239-fc52dn3v 198 2 tissues tissue NNS cord-355239-fc52dn3v 198 3 represent represent VBP cord-355239-fc52dn3v 198 4 the the DT cord-355239-fc52dn3v 198 5 site site NN cord-355239-fc52dn3v 198 6 of of IN cord-355239-fc52dn3v 198 7 infection infection NN cord-355239-fc52dn3v 198 8 or or CC cord-355239-fc52dn3v 198 9 route route NN cord-355239-fc52dn3v 198 10 of of IN cord-355239-fc52dn3v 198 11 access access NN cord-355239-fc52dn3v 198 12 for for IN cord-355239-fc52dn3v 198 13 most most JJS cord-355239-fc52dn3v 198 14 parasites parasite NNS cord-355239-fc52dn3v 198 15 , , , cord-355239-fc52dn3v 198 16 including include VBG cord-355239-fc52dn3v 198 17 viruses virus NNS cord-355239-fc52dn3v 198 18 , , , cord-355239-fc52dn3v 198 19 bacteria bacteria NNS cord-355239-fc52dn3v 198 20 and and CC cord-355239-fc52dn3v 198 21 protozoa protozoan NNS cord-355239-fc52dn3v 198 22 [ [ -LRB- cord-355239-fc52dn3v 198 23 58 58 CD cord-355239-fc52dn3v 198 24 ] ] -RRB- cord-355239-fc52dn3v 198 25 . . . cord-355239-fc52dn3v 199 1 On on IN cord-355239-fc52dn3v 199 2 the the DT cord-355239-fc52dn3v 199 3 surface surface NN cord-355239-fc52dn3v 199 4 of of IN cord-355239-fc52dn3v 199 5 the the DT cord-355239-fc52dn3v 199 6 mucosal mucosal JJ cord-355239-fc52dn3v 199 7 tissues tissue NNS cord-355239-fc52dn3v 199 8 of of IN cord-355239-fc52dn3v 199 9 the the DT cord-355239-fc52dn3v 199 10 gastrointestinal gastrointestinal JJ cord-355239-fc52dn3v 199 11 tracts tract NNS cord-355239-fc52dn3v 199 12 , , , cord-355239-fc52dn3v 199 13 various various JJ cord-355239-fc52dn3v 199 14 carbohydrate carbohydrate NN cord-355239-fc52dn3v 199 15 moieties moiety NNS cord-355239-fc52dn3v 199 16 are be VBP cord-355239-fc52dn3v 199 17 present present JJ cord-355239-fc52dn3v 199 18 and and CC cord-355239-fc52dn3v 199 19 play play VB cord-355239-fc52dn3v 199 20 a a DT cord-355239-fc52dn3v 199 21 crucial crucial JJ cord-355239-fc52dn3v 199 22 role role NN cord-355239-fc52dn3v 199 23 in in IN cord-355239-fc52dn3v 199 24 infection infection NN cord-355239-fc52dn3v 199 25 . . . cord-355239-fc52dn3v 200 1 Mucosal Mucosal NNP cord-355239-fc52dn3v 200 2 surfaces surface NNS cord-355239-fc52dn3v 200 3 are be VBP cord-355239-fc52dn3v 200 4 coated coat VBN cord-355239-fc52dn3v 200 5 with with IN cord-355239-fc52dn3v 200 6 a a DT cord-355239-fc52dn3v 200 7 layer layer NN cord-355239-fc52dn3v 200 8 of of IN cord-355239-fc52dn3v 200 9 viscous viscous JJ cord-355239-fc52dn3v 200 10 mucus mucus NN cord-355239-fc52dn3v 200 11 that that WDT cord-355239-fc52dn3v 200 12 ranges range VBZ cord-355239-fc52dn3v 200 13 in in IN cord-355239-fc52dn3v 200 14 thickness thickness NN cord-355239-fc52dn3v 200 15 from from IN cord-355239-fc52dn3v 200 16 300 300 CD cord-355239-fc52dn3v 200 17 μm μm NNS cord-355239-fc52dn3v 200 18 in in IN cord-355239-fc52dn3v 200 19 the the DT cord-355239-fc52dn3v 200 20 stomach stomach NN cord-355239-fc52dn3v 200 21 to to IN cord-355239-fc52dn3v 200 22 700 700 CD cord-355239-fc52dn3v 200 23 μm μm NNS cord-355239-fc52dn3v 200 24 in in IN cord-355239-fc52dn3v 200 25 the the DT cord-355239-fc52dn3v 200 26 intestine intestine NN cord-355239-fc52dn3v 200 27 [ [ -LRB- cord-355239-fc52dn3v 200 28 59 59 CD cord-355239-fc52dn3v 200 29 ] ] -RRB- cord-355239-fc52dn3v 201 1 [ [ -LRB- cord-355239-fc52dn3v 201 2 60 60 CD cord-355239-fc52dn3v 201 3 ] ] -RRB- cord-355239-fc52dn3v 201 4 [ [ -LRB- cord-355239-fc52dn3v 201 5 61 61 CD cord-355239-fc52dn3v 201 6 ] ] -RRB- cord-355239-fc52dn3v 201 7 . . . cord-355239-fc52dn3v 202 1 Mucin mucin NN cord-355239-fc52dn3v 202 2 glycoproteins glycoprotein NNS cord-355239-fc52dn3v 202 3 from from IN cord-355239-fc52dn3v 202 4 mucus mucus NN cord-355239-fc52dn3v 202 5 - - HYPH cord-355239-fc52dn3v 202 6 producing produce VBG cord-355239-fc52dn3v 202 7 cells cell NNS cord-355239-fc52dn3v 202 8 in in IN cord-355239-fc52dn3v 202 9 the the DT cord-355239-fc52dn3v 202 10 epithelium epithelium NN cord-355239-fc52dn3v 202 11 or or CC cord-355239-fc52dn3v 202 12 submucosal submucosal NN cord-355239-fc52dn3v 202 13 glands gland NNS cord-355239-fc52dn3v 202 14 are be VBP cord-355239-fc52dn3v 202 15 the the DT cord-355239-fc52dn3v 202 16 major major JJ cord-355239-fc52dn3v 202 17 macromolecular macromolecular JJ cord-355239-fc52dn3v 202 18 constituent constituent NN cord-355239-fc52dn3v 202 19 of of IN cord-355239-fc52dn3v 202 20 mucus mucus NN cord-355239-fc52dn3v 202 21 and and CC cord-355239-fc52dn3v 202 22 are be VBP cord-355239-fc52dn3v 202 23 responsible responsible JJ cord-355239-fc52dn3v 202 24 for for IN cord-355239-fc52dn3v 202 25 the the DT cord-355239-fc52dn3v 202 26 viscous viscous JJ cord-355239-fc52dn3v 202 27 properties property NNS cord-355239-fc52dn3v 202 28 of of IN cord-355239-fc52dn3v 202 29 the the DT cord-355239-fc52dn3v 202 30 mucus mucus NN cord-355239-fc52dn3v 202 31 gel gel NN cord-355239-fc52dn3v 202 32 . . . cord-355239-fc52dn3v 203 1 In in IN cord-355239-fc52dn3v 203 2 addition addition NN cord-355239-fc52dn3v 203 3 to to IN cord-355239-fc52dn3v 203 4 forming form VBG cord-355239-fc52dn3v 203 5 a a DT cord-355239-fc52dn3v 203 6 relatively relatively RB cord-355239-fc52dn3v 203 7 impervious impervious JJ cord-355239-fc52dn3v 203 8 gel gel NN cord-355239-fc52dn3v 203 9 , , , cord-355239-fc52dn3v 203 10 which which WDT cord-355239-fc52dn3v 203 11 acts act VBZ cord-355239-fc52dn3v 203 12 as as IN cord-355239-fc52dn3v 203 13 a a DT cord-355239-fc52dn3v 203 14 lubricant lubricant NN cord-355239-fc52dn3v 203 15 , , , cord-355239-fc52dn3v 203 16 a a DT cord-355239-fc52dn3v 203 17 physical physical JJ cord-355239-fc52dn3v 203 18 barrier barrier NN cord-355239-fc52dn3v 203 19 and and CC cord-355239-fc52dn3v 203 20 a a DT cord-355239-fc52dn3v 203 21 trap trap NN cord-355239-fc52dn3v 203 22 for for IN cord-355239-fc52dn3v 203 23 microbes microbe NNS cord-355239-fc52dn3v 203 24 , , , cord-355239-fc52dn3v 203 25 mucus mucus NN cord-355239-fc52dn3v 203 26 provides provide VBZ cord-355239-fc52dn3v 203 27 a a DT cord-355239-fc52dn3v 203 28 matrix matrix NN cord-355239-fc52dn3v 203 29 for for IN cord-355239-fc52dn3v 203 30 a a DT cord-355239-fc52dn3v 203 31 rich rich JJ cord-355239-fc52dn3v 203 32 array array NN cord-355239-fc52dn3v 203 33 of of IN cord-355239-fc52dn3v 203 34 antimicrobial antimicrobial JJ cord-355239-fc52dn3v 203 35 molecules molecule NNS cord-355239-fc52dn3v 203 36 . . . cord-355239-fc52dn3v 204 1 Underneath underneath IN cord-355239-fc52dn3v 204 2 the the DT cord-355239-fc52dn3v 204 3 mucus mucus NN cord-355239-fc52dn3v 204 4 layer layer NN cord-355239-fc52dn3v 204 5 , , , cord-355239-fc52dn3v 204 6 the the DT cord-355239-fc52dn3v 204 7 cells cell NNS cord-355239-fc52dn3v 204 8 present present VBP cord-355239-fc52dn3v 204 9 a a DT cord-355239-fc52dn3v 204 10 dense dense JJ cord-355239-fc52dn3v 204 11 forest forest NN cord-355239-fc52dn3v 204 12 of of IN cord-355239-fc52dn3v 204 13 highly highly RB cord-355239-fc52dn3v 204 14 diverse diverse JJ cord-355239-fc52dn3v 204 15 glycoproteins glycoprotein NNS cord-355239-fc52dn3v 204 16 and and CC cord-355239-fc52dn3v 204 17 glycolipids glycolipid NNS cord-355239-fc52dn3v 204 18 , , , cord-355239-fc52dn3v 204 19 which which WDT cord-355239-fc52dn3v 204 20 form form VBP cord-355239-fc52dn3v 204 21 the the DT cord-355239-fc52dn3v 204 22 glycocalyx glycocalyx NNP cord-355239-fc52dn3v 204 23 . . . cord-355239-fc52dn3v 205 1 Membrane membrane NN cord-355239-fc52dn3v 205 2 - - HYPH cord-355239-fc52dn3v 205 3 anchored anchor VBN cord-355239-fc52dn3v 205 4 cell cell NN cord-355239-fc52dn3v 205 5 - - HYPH cord-355239-fc52dn3v 205 6 surface surface NN cord-355239-fc52dn3v 205 7 mucin mucin NN cord-355239-fc52dn3v 205 8 glycoproteins glycoprotein NNS cord-355239-fc52dn3v 205 9 are be VBP cord-355239-fc52dn3v 205 10 a a DT cord-355239-fc52dn3v 205 11 major major JJ cord-355239-fc52dn3v 205 12 constituent constituent NN cord-355239-fc52dn3v 205 13 of of IN cord-355239-fc52dn3v 205 14 the the DT cord-355239-fc52dn3v 205 15 glycocalyx glycocalyx NNP cord-355239-fc52dn3v 205 16 in in IN cord-355239-fc52dn3v 205 17 all all DT cord-355239-fc52dn3v 205 18 mucosal mucosal JJ cord-355239-fc52dn3v 205 19 tissues tissue NNS cord-355239-fc52dn3v 205 20 . . . cord-355239-fc52dn3v 206 1 The the DT cord-355239-fc52dn3v 206 2 oligosaccharide oligosaccharide NN cord-355239-fc52dn3v 206 3 moieties moiety NNS cord-355239-fc52dn3v 206 4 of of IN cord-355239-fc52dn3v 206 5 the the DT cord-355239-fc52dn3v 206 6 molecules molecule NNS cord-355239-fc52dn3v 206 7 that that WDT cord-355239-fc52dn3v 206 8 form form VBP cord-355239-fc52dn3v 206 9 the the DT cord-355239-fc52dn3v 206 10 glycocalyx glycocalyx NNP cord-355239-fc52dn3v 206 11 and and CC cord-355239-fc52dn3v 206 12 the the DT cord-355239-fc52dn3v 206 13 mucus mucus NN cord-355239-fc52dn3v 206 14 layer layer NN cord-355239-fc52dn3v 206 15 are be VBP cord-355239-fc52dn3v 206 16 highly highly RB cord-355239-fc52dn3v 206 17 diverse diverse JJ cord-355239-fc52dn3v 206 18 , , , cord-355239-fc52dn3v 206 19 and and CC cord-355239-fc52dn3v 206 20 the the DT cord-355239-fc52dn3v 206 21 average average JJ cord-355239-fc52dn3v 206 22 turnover turnover NN cord-355239-fc52dn3v 206 23 time time NN cord-355239-fc52dn3v 206 24 of of IN cord-355239-fc52dn3v 206 25 the the DT cord-355239-fc52dn3v 206 26 human human JJ cord-355239-fc52dn3v 206 27 jejunal jejunal NNP cord-355239-fc52dn3v 206 28 glycocalyx glycocalyx NNP cord-355239-fc52dn3v 206 29 is be VBZ cord-355239-fc52dn3v 206 30 6 6 CD cord-355239-fc52dn3v 206 31 - - SYM cord-355239-fc52dn3v 206 32 12 12 CD cord-355239-fc52dn3v 206 33 h h NN cord-355239-fc52dn3v 206 34 [ [ -LRB- cord-355239-fc52dn3v 206 35 62 62 CD cord-355239-fc52dn3v 206 36 ] ] -RRB- cord-355239-fc52dn3v 206 37 . . . cord-355239-fc52dn3v 207 1 Consequently consequently RB cord-355239-fc52dn3v 207 2 , , , cord-355239-fc52dn3v 207 3 both both CC cord-355239-fc52dn3v 207 4 the the DT cord-355239-fc52dn3v 207 5 secreted secrete VBN cord-355239-fc52dn3v 207 6 and and CC cord-355239-fc52dn3v 207 7 adherent adherent JJ cord-355239-fc52dn3v 207 8 mucosal mucosal JJ cord-355239-fc52dn3v 207 9 barriers barrier NNS cord-355239-fc52dn3v 207 10 are be VBP cord-355239-fc52dn3v 207 11 constantly constantly RB cord-355239-fc52dn3v 207 12 renewed renew VBN cord-355239-fc52dn3v 207 13 and and CC cord-355239-fc52dn3v 207 14 can can MD cord-355239-fc52dn3v 207 15 rapidly rapidly RB cord-355239-fc52dn3v 207 16 adjust adjust VB cord-355239-fc52dn3v 207 17 to to IN cord-355239-fc52dn3v 207 18 changes change NNS cord-355239-fc52dn3v 207 19 in in IN cord-355239-fc52dn3v 207 20 the the DT cord-355239-fc52dn3v 207 21 environment environment NN cord-355239-fc52dn3v 207 22 , , , cord-355239-fc52dn3v 207 23 for for IN cord-355239-fc52dn3v 207 24 example example NN cord-355239-fc52dn3v 207 25 , , , cord-355239-fc52dn3v 207 26 in in IN cord-355239-fc52dn3v 207 27 response response NN cord-355239-fc52dn3v 207 28 to to IN cord-355239-fc52dn3v 207 29 microbial microbial JJ cord-355239-fc52dn3v 207 30 infection infection NN cord-355239-fc52dn3v 207 31 . . . cord-355239-fc52dn3v 208 1 Epithelial epithelial JJ cord-355239-fc52dn3v 208 2 mucins mucin NNS cord-355239-fc52dn3v 208 3 are be VBP cord-355239-fc52dn3v 208 4 a a DT cord-355239-fc52dn3v 208 5 heterogenous heterogenous JJ cord-355239-fc52dn3v 208 6 family family NN cord-355239-fc52dn3v 208 7 of of IN cord-355239-fc52dn3v 208 8 large large JJ cord-355239-fc52dn3v 208 9 complex complex JJ cord-355239-fc52dn3v 208 10 glycoproteins glycoprotein NNS cord-355239-fc52dn3v 208 11 containing contain VBG cord-355239-fc52dn3v 208 12 a a DT cord-355239-fc52dn3v 208 13 dense dense JJ cord-355239-fc52dn3v 208 14 array array NN cord-355239-fc52dn3v 208 15 of of IN cord-355239-fc52dn3v 208 16 Olinked Olinked NNP cord-355239-fc52dn3v 208 17 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 208 18 typically typically RB cord-355239-fc52dn3v 208 19 comprising comprise VBG cord-355239-fc52dn3v 208 20 over over IN cord-355239-fc52dn3v 208 21 70 70 CD cord-355239-fc52dn3v 208 22 % % NN cord-355239-fc52dn3v 208 23 of of IN cord-355239-fc52dn3v 208 24 their -PRON- PRP$ cord-355239-fc52dn3v 208 25 mass mass NN cord-355239-fc52dn3v 208 26 . . . cord-355239-fc52dn3v 209 1 The the DT cord-355239-fc52dn3v 209 2 carbohydrate carbohydrate NN cord-355239-fc52dn3v 209 3 structures structure NNS cord-355239-fc52dn3v 209 4 present present JJ cord-355239-fc52dn3v 209 5 on on IN cord-355239-fc52dn3v 209 6 mucosal mucosal JJ cord-355239-fc52dn3v 209 7 surfaces surface NNS cord-355239-fc52dn3v 209 8 vary vary VBP cord-355239-fc52dn3v 209 9 according accord VBG cord-355239-fc52dn3v 209 10 to to IN cord-355239-fc52dn3v 209 11 cell cell NN cord-355239-fc52dn3v 209 12 lineage lineage NN cord-355239-fc52dn3v 209 13 , , , cord-355239-fc52dn3v 209 14 tissue tissue NN cord-355239-fc52dn3v 209 15 location location NN cord-355239-fc52dn3v 209 16 and and CC cord-355239-fc52dn3v 209 17 developmental developmental JJ cord-355239-fc52dn3v 209 18 stage stage NN cord-355239-fc52dn3v 209 19 [ [ -LRB- cord-355239-fc52dn3v 209 20 58 58 CD cord-355239-fc52dn3v 209 21 ] ] -RRB- cord-355239-fc52dn3v 209 22 . . . cord-355239-fc52dn3v 210 1 Mucin mucin NN cord-355239-fc52dn3v 210 2 glycosylation glycosylation NN cord-355239-fc52dn3v 210 3 can can MD cord-355239-fc52dn3v 210 4 alter alter VB cord-355239-fc52dn3v 210 5 in in IN cord-355239-fc52dn3v 210 6 response response NN cord-355239-fc52dn3v 210 7 to to IN cord-355239-fc52dn3v 210 8 mucosal mucosal JJ cord-355239-fc52dn3v 210 9 infection infection NN cord-355239-fc52dn3v 210 10 and and CC cord-355239-fc52dn3v 210 11 inflammation inflammation NN cord-355239-fc52dn3v 210 12 , , , cord-355239-fc52dn3v 210 13 and and CC cord-355239-fc52dn3v 210 14 this this DT cord-355239-fc52dn3v 210 15 may may MD cord-355239-fc52dn3v 210 16 be be VB cord-355239-fc52dn3v 210 17 an an DT cord-355239-fc52dn3v 210 18 important important JJ cord-355239-fc52dn3v 210 19 mechanism mechanism NN cord-355239-fc52dn3v 210 20 for for IN cord-355239-fc52dn3v 210 21 unfavorable unfavorable JJ cord-355239-fc52dn3v 210 22 changes change NNS cord-355239-fc52dn3v 210 23 in in IN cord-355239-fc52dn3v 210 24 the the DT cord-355239-fc52dn3v 210 25 niche niche NN cord-355239-fc52dn3v 210 26 occupied occupy VBN cord-355239-fc52dn3v 210 27 by by IN cord-355239-fc52dn3v 210 28 mucosal mucosal JJ cord-355239-fc52dn3v 210 29 pathogens pathogen NNS cord-355239-fc52dn3v 210 30 . . . cord-355239-fc52dn3v 211 1 The the DT cord-355239-fc52dn3v 211 2 O o NN cord-355239-fc52dn3v 211 3 - - HYPH cord-355239-fc52dn3v 211 4 linked link VBN cord-355239-fc52dn3v 211 5 glycans glycan NNS cord-355239-fc52dn3v 211 6 of of IN cord-355239-fc52dn3v 211 7 muchin muchin NNP cord-355239-fc52dn3v 211 8 proteins protein NNS cord-355239-fc52dn3v 211 9 contain contain VBP cord-355239-fc52dn3v 211 10 1 1 CD cord-355239-fc52dn3v 211 11 - - SYM cord-355239-fc52dn3v 211 12 20 20 CD cord-355239-fc52dn3v 211 13 residues residue NNS cord-355239-fc52dn3v 211 14 , , , cord-355239-fc52dn3v 211 15 which which WDT cord-355239-fc52dn3v 211 16 occur occur VBP cord-355239-fc52dn3v 211 17 both both DT cord-355239-fc52dn3v 211 18 as as IN cord-355239-fc52dn3v 211 19 linear linear JJ cord-355239-fc52dn3v 211 20 and and CC cord-355239-fc52dn3v 211 21 branched branched JJ cord-355239-fc52dn3v 211 22 structures structure NNS cord-355239-fc52dn3v 211 23 [ [ -LRB- cord-355239-fc52dn3v 211 24 58 58 CD cord-355239-fc52dn3v 211 25 ] ] -RRB- cord-355239-fc52dn3v 211 26 . . . cord-355239-fc52dn3v 212 1 In in IN cord-355239-fc52dn3v 212 2 addition addition NN cord-355239-fc52dn3v 212 3 to to IN cord-355239-fc52dn3v 212 4 the the DT cord-355239-fc52dn3v 212 5 O o NN cord-355239-fc52dn3v 212 6 - - HYPH cord-355239-fc52dn3v 212 7 linked link VBN cord-355239-fc52dn3v 212 8 glycans glycan NNS cord-355239-fc52dn3v 212 9 , , , cord-355239-fc52dn3v 212 10 mucins mucin NNS cord-355239-fc52dn3v 212 11 contain contain VBP cord-355239-fc52dn3v 212 12 a a DT cord-355239-fc52dn3v 212 13 smaller small JJR cord-355239-fc52dn3v 212 14 number number NN cord-355239-fc52dn3v 212 15 of of IN cord-355239-fc52dn3v 212 16 N n NN cord-355239-fc52dn3v 212 17 - - HYPH cord-355239-fc52dn3v 212 18 linked link VBN cord-355239-fc52dn3v 212 19 oligosaccharides oligosaccharide NNS cord-355239-fc52dn3v 212 20 , , , cord-355239-fc52dn3v 212 21 which which WDT cord-355239-fc52dn3v 212 22 have have VBP cord-355239-fc52dn3v 212 23 been be VBN cord-355239-fc52dn3v 212 24 implicated implicate VBN cord-355239-fc52dn3v 212 25 in in IN cord-355239-fc52dn3v 212 26 folding folding NN cord-355239-fc52dn3v 212 27 , , , cord-355239-fc52dn3v 212 28 oligomerization oligomerization NN cord-355239-fc52dn3v 212 29 ( ( -LRB- cord-355239-fc52dn3v 212 30 MUC2 MUC2 NNP cord-355239-fc52dn3v 212 31 ) ) -RRB- cord-355239-fc52dn3v 212 32 and and CC cord-355239-fc52dn3v 212 33 surface surface NN cord-355239-fc52dn3v 212 34 localization localization NN cord-355239-fc52dn3v 212 35 ( ( -LRB- cord-355239-fc52dn3v 212 36 MUC17 MUC17 NNP cord-355239-fc52dn3v 212 37 ) ) -RRB- cord-355239-fc52dn3v 212 38 [ [ -LRB- cord-355239-fc52dn3v 212 39 63 63 CD cord-355239-fc52dn3v 212 40 ] ] -RRB- cord-355239-fc52dn3v 212 41 [ [ -LRB- cord-355239-fc52dn3v 212 42 64 64 CD cord-355239-fc52dn3v 212 43 ] ] -RRB- cord-355239-fc52dn3v 212 44 [ [ -LRB- cord-355239-fc52dn3v 212 45 65 65 CD cord-355239-fc52dn3v 212 46 ] ] -RRB- cord-355239-fc52dn3v 212 47 . . . cord-355239-fc52dn3v 213 1 The the DT cord-355239-fc52dn3v 213 2 terminal terminal JJ cord-355239-fc52dn3v 213 3 structures structure NNS cord-355239-fc52dn3v 213 4 of of IN cord-355239-fc52dn3v 213 5 mucin mucin NN cord-355239-fc52dn3v 213 6 oligosaccharides oligosaccharide NNS cord-355239-fc52dn3v 213 7 are be VBP cord-355239-fc52dn3v 213 8 highly highly RB cord-355239-fc52dn3v 213 9 heterogeneous heterogeneous JJ cord-355239-fc52dn3v 213 10 K. K. NNP cord-355239-fc52dn3v 213 11 Kato Kato NNP cord-355239-fc52dn3v 213 12 et et NNP cord-355239-fc52dn3v 213 13 al al NNP cord-355239-fc52dn3v 213 14 . . . cord-355239-fc52dn3v 214 1 and and CC cord-355239-fc52dn3v 214 2 vary vary VBP cord-355239-fc52dn3v 214 3 between between IN cord-355239-fc52dn3v 214 4 and and CC cord-355239-fc52dn3v 214 5 within within IN cord-355239-fc52dn3v 214 6 species specie NNS cord-355239-fc52dn3v 214 7 as as RB cord-355239-fc52dn3v 214 8 well well RB cord-355239-fc52dn3v 214 9 as as IN cord-355239-fc52dn3v 214 10 between between IN cord-355239-fc52dn3v 214 11 and and CC cord-355239-fc52dn3v 214 12 even even RB cord-355239-fc52dn3v 214 13 within within IN cord-355239-fc52dn3v 214 14 tissues tissue NNS cord-355239-fc52dn3v 214 15 . . . cord-355239-fc52dn3v 215 1 The the DT cord-355239-fc52dn3v 215 2 array array NN cord-355239-fc52dn3v 215 3 of of IN cord-355239-fc52dn3v 215 4 oligosaccharide oligosaccharide NN cord-355239-fc52dn3v 215 5 structures structure NNS cord-355239-fc52dn3v 215 6 on on IN cord-355239-fc52dn3v 215 7 individual individual JJ cord-355239-fc52dn3v 215 8 mucin mucin NN cord-355239-fc52dn3v 215 9 molecules molecule NNS cord-355239-fc52dn3v 215 10 is be VBZ cord-355239-fc52dn3v 215 11 also also RB cord-355239-fc52dn3v 215 12 somewhat somewhat RB cord-355239-fc52dn3v 215 13 determined determined JJ cord-355239-fc52dn3v 215 14 by by IN cord-355239-fc52dn3v 215 15 stochastic stochastic JJ cord-355239-fc52dn3v 215 16 events event NNS cord-355239-fc52dn3v 215 17 as as IN cord-355239-fc52dn3v 215 18 the the DT cord-355239-fc52dn3v 215 19 mucin mucin NN cord-355239-fc52dn3v 215 20 protein protein NN cord-355239-fc52dn3v 215 21 moves move VBZ cord-355239-fc52dn3v 215 22 through through IN cord-355239-fc52dn3v 215 23 the the DT cord-355239-fc52dn3v 215 24 Golgi Golgi NNP cord-355239-fc52dn3v 215 25 apparatus apparatus NN cord-355239-fc52dn3v 215 26 [ [ -LRB- cord-355239-fc52dn3v 215 27 66 66 CD cord-355239-fc52dn3v 215 28 ] ] -RRB- cord-355239-fc52dn3v 215 29 . . . cord-355239-fc52dn3v 216 1 The the DT cord-355239-fc52dn3v 216 2 secreted secrete VBN cord-355239-fc52dn3v 216 3 mucins mucin NNS cord-355239-fc52dn3v 216 4 themselves -PRON- PRP cord-355239-fc52dn3v 216 5 likely likely JJ cord-355239-fc52dn3v 216 6 function function VBP cord-355239-fc52dn3v 216 7 as as IN cord-355239-fc52dn3v 216 8 decoys decoy NNS cord-355239-fc52dn3v 216 9 for for IN cord-355239-fc52dn3v 216 10 adhesins adhesin NNS cord-355239-fc52dn3v 216 11 that that WDT cord-355239-fc52dn3v 216 12 have have VBP cord-355239-fc52dn3v 216 13 been be VBN cord-355239-fc52dn3v 216 14 evolved evolve VBN cord-355239-fc52dn3v 216 15 by by IN cord-355239-fc52dn3v 216 16 pathogens pathogen NNS cord-355239-fc52dn3v 216 17 to to TO cord-355239-fc52dn3v 216 18 engage engage VB cord-355239-fc52dn3v 216 19 the the DT cord-355239-fc52dn3v 216 20 cell cell NN cord-355239-fc52dn3v 216 21 surface surface NN cord-355239-fc52dn3v 216 22 , , , cord-355239-fc52dn3v 216 23 as as IN cord-355239-fc52dn3v 216 24 the the DT cord-355239-fc52dn3v 216 25 mucins mucin NNS cord-355239-fc52dn3v 216 26 express express VBP cord-355239-fc52dn3v 216 27 many many JJ cord-355239-fc52dn3v 216 28 of of IN cord-355239-fc52dn3v 216 29 the the DT cord-355239-fc52dn3v 216 30 oligosaccharide oligosaccharide NN cord-355239-fc52dn3v 216 31 structures structure NNS cord-355239-fc52dn3v 216 32 found find VBN cord-355239-fc52dn3v 216 33 on on IN cord-355239-fc52dn3v 216 34 the the DT cord-355239-fc52dn3v 216 35 cell cell NN cord-355239-fc52dn3v 216 36 surface surface NN cord-355239-fc52dn3v 216 37 and and CC cord-355239-fc52dn3v 216 38 are be VBP cord-355239-fc52dn3v 216 39 constitutively constitutively RB cord-355239-fc52dn3v 216 40 produced produce VBN cord-355239-fc52dn3v 216 41 in in IN cord-355239-fc52dn3v 216 42 large large JJ cord-355239-fc52dn3v 216 43 amounts amount NNS cord-355239-fc52dn3v 216 44 , , , cord-355239-fc52dn3v 216 45 constantly constantly RB cord-355239-fc52dn3v 216 46 washing wash VBG cord-355239-fc52dn3v 216 47 the the DT cord-355239-fc52dn3v 216 48 mucosal mucosal JJ cord-355239-fc52dn3v 216 49 surfaces surface NNS cord-355239-fc52dn3v 216 50 [ [ -LRB- cord-355239-fc52dn3v 216 51 58 58 CD cord-355239-fc52dn3v 216 52 ] ] -RRB- cord-355239-fc52dn3v 216 53 . . . cord-355239-fc52dn3v 217 1 Proteoglycans proteoglycan NNS cord-355239-fc52dn3v 217 2 are be VBP cord-355239-fc52dn3v 217 3 present present JJ cord-355239-fc52dn3v 217 4 on on IN cord-355239-fc52dn3v 217 5 the the DT cord-355239-fc52dn3v 217 6 cell cell NN cord-355239-fc52dn3v 217 7 surface surface NN cord-355239-fc52dn3v 217 8 [ [ -LRB- cord-355239-fc52dn3v 217 9 67 67 CD cord-355239-fc52dn3v 217 10 ] ] -RRB- cord-355239-fc52dn3v 217 11 and and CC cord-355239-fc52dn3v 217 12 are be VBP cord-355239-fc52dn3v 217 13 also also RB cord-355239-fc52dn3v 217 14 components component NNS cord-355239-fc52dn3v 217 15 of of IN cord-355239-fc52dn3v 217 16 glycocalyx glycocalyx NNP cord-355239-fc52dn3v 217 17 . . . cord-355239-fc52dn3v 218 1 Glycosaminoglycan glycosaminoglycan JJ cord-355239-fc52dn3v 218 2 chains chain NNS cord-355239-fc52dn3v 218 3 are be VBP cord-355239-fc52dn3v 218 4 composed compose VBN cord-355239-fc52dn3v 218 5 of of IN cord-355239-fc52dn3v 218 6 highly highly RB cord-355239-fc52dn3v 218 7 sulfated sulfated JJ cord-355239-fc52dn3v 218 8 saccharides saccharide NNS cord-355239-fc52dn3v 218 9 that that WDT cord-355239-fc52dn3v 218 10 give give VBP cord-355239-fc52dn3v 218 11 the the DT cord-355239-fc52dn3v 218 12 cell cell NN cord-355239-fc52dn3v 218 13 surface surface NN cord-355239-fc52dn3v 218 14 a a DT cord-355239-fc52dn3v 218 15 potent potent JJ cord-355239-fc52dn3v 218 16 negative negative JJ cord-355239-fc52dn3v 218 17 charge charge NN cord-355239-fc52dn3v 218 18 . . . cord-355239-fc52dn3v 219 1 One one CD cord-355239-fc52dn3v 219 2 of of IN cord-355239-fc52dn3v 219 3 the the DT cord-355239-fc52dn3v 219 4 prototypical prototypical JJ cord-355239-fc52dn3v 219 5 membrane membrane NN cord-355239-fc52dn3v 219 6 proteoglycans proteoglycan NNS cord-355239-fc52dn3v 219 7 is be VBZ cord-355239-fc52dn3v 219 8 syndecan-1 syndecan-1 NNP cord-355239-fc52dn3v 219 9 , , , cord-355239-fc52dn3v 219 10 which which WDT cord-355239-fc52dn3v 219 11 carries carry VBZ cord-355239-fc52dn3v 219 12 conserved conserved JJ cord-355239-fc52dn3v 219 13 attachment attachment NN cord-355239-fc52dn3v 219 14 sites site NNS cord-355239-fc52dn3v 219 15 for for IN cord-355239-fc52dn3v 219 16 glycosaminoglycan glycosaminoglycan JJ cord-355239-fc52dn3v 219 17 chains chain NNS cord-355239-fc52dn3v 219 18 [ [ -LRB- cord-355239-fc52dn3v 219 19 67 67 CD cord-355239-fc52dn3v 219 20 ] ] -RRB- cord-355239-fc52dn3v 219 21 . . . cord-355239-fc52dn3v 220 1 The the DT cord-355239-fc52dn3v 220 2 syndecans syndecan NNS cord-355239-fc52dn3v 220 3 exemplify exemplify VBP cord-355239-fc52dn3v 220 4 hybrid hybrid JJ cord-355239-fc52dn3v 220 5 proteoglycans proteoglycan NNS cord-355239-fc52dn3v 220 6 because because IN cord-355239-fc52dn3v 220 7 they -PRON- PRP cord-355239-fc52dn3v 220 8 contain contain VBP cord-355239-fc52dn3v 220 9 mixtures mixture NNS cord-355239-fc52dn3v 220 10 of of IN cord-355239-fc52dn3v 220 11 the the DT cord-355239-fc52dn3v 220 12 two two CD cord-355239-fc52dn3v 220 13 major major JJ cord-355239-fc52dn3v 220 14 types type NNS cord-355239-fc52dn3v 220 15 of of IN cord-355239-fc52dn3v 220 16 glycosaminoglycan glycosaminoglycan JJ cord-355239-fc52dn3v 220 17 chains chain NNS cord-355239-fc52dn3v 220 18 , , , cord-355239-fc52dn3v 220 19 heparan heparan NN cord-355239-fc52dn3v 220 20 sulfate sulfate NN cord-355239-fc52dn3v 220 21 and and CC cord-355239-fc52dn3v 220 22 chondroitin chondroitin NN cord-355239-fc52dn3v 220 23 sulfate sulfate NN cord-355239-fc52dn3v 220 24 . . . cord-355239-fc52dn3v 221 1 The the DT cord-355239-fc52dn3v 221 2 other other JJ cord-355239-fc52dn3v 221 3 major major JJ cord-355239-fc52dn3v 221 4 family family NN cord-355239-fc52dn3v 221 5 of of IN cord-355239-fc52dn3v 221 6 membrane membrane NN cord-355239-fc52dn3v 221 7 proteoglycans proteoglycan NNS cord-355239-fc52dn3v 221 8 is be VBZ cord-355239-fc52dn3v 221 9 the the DT cord-355239-fc52dn3v 221 10 glypicans glypican NNS cord-355239-fc52dn3v 221 11 , , , cord-355239-fc52dn3v 221 12 which which WDT cord-355239-fc52dn3v 221 13 contain contain VBP cord-355239-fc52dn3v 221 14 GPI GPI NNP cord-355239-fc52dn3v 221 15 anchors anchor NNS cord-355239-fc52dn3v 221 16 in in IN cord-355239-fc52dn3v 221 17 a a DT cord-355239-fc52dn3v 221 18 tissue tissue NN cord-355239-fc52dn3v 221 19 - - HYPH cord-355239-fc52dn3v 221 20 specific specific JJ cord-355239-fc52dn3v 221 21 and and CC cord-355239-fc52dn3v 221 22 temporally temporally RB cord-355239-fc52dn3v 221 23 regulated regulate VBN cord-355239-fc52dn3v 221 24 manner manner NN cord-355239-fc52dn3v 221 25 . . . cord-355239-fc52dn3v 222 1 Their -PRON- PRP$ cord-355239-fc52dn3v 222 2 presence presence NN cord-355239-fc52dn3v 222 3 in in IN cord-355239-fc52dn3v 222 4 the the DT cord-355239-fc52dn3v 222 5 basolateral basolateral JJ cord-355239-fc52dn3v 222 6 membranes membrane NNS cord-355239-fc52dn3v 222 7 of of IN cord-355239-fc52dn3v 222 8 polarized polarized JJ cord-355239-fc52dn3v 222 9 cells cell NNS cord-355239-fc52dn3v 222 10 varies vary VBZ cord-355239-fc52dn3v 222 11 [ [ -LRB- cord-355239-fc52dn3v 222 12 68 68 CD cord-355239-fc52dn3v 222 13 ] ] -RRB- cord-355239-fc52dn3v 222 14 . . . cord-355239-fc52dn3v 223 1 Glycolipids glycolipid NNS cord-355239-fc52dn3v 223 2 are be VBP cord-355239-fc52dn3v 223 3 also also RB cord-355239-fc52dn3v 223 4 a a DT cord-355239-fc52dn3v 223 5 component component NN cord-355239-fc52dn3v 223 6 of of IN cord-355239-fc52dn3v 223 7 the the DT cord-355239-fc52dn3v 223 8 cell cell NN cord-355239-fc52dn3v 223 9 membrane membrane NN cord-355239-fc52dn3v 223 10 . . . cord-355239-fc52dn3v 224 1 A a DT cord-355239-fc52dn3v 224 2 large large JJ cord-355239-fc52dn3v 224 3 variety variety NN cord-355239-fc52dn3v 224 4 of of IN cord-355239-fc52dn3v 224 5 glycolipids glycolipid NNS cord-355239-fc52dn3v 224 6 is be VBZ cord-355239-fc52dn3v 224 7 present present JJ cord-355239-fc52dn3v 224 8 on on IN cord-355239-fc52dn3v 224 9 the the DT cord-355239-fc52dn3v 224 10 surface surface NN cord-355239-fc52dn3v 224 11 of of IN cord-355239-fc52dn3v 224 12 animal animal NN cord-355239-fc52dn3v 224 13 cells cell NNS cord-355239-fc52dn3v 224 14 . . . cord-355239-fc52dn3v 225 1 The the DT cord-355239-fc52dn3v 225 2 carbohydrate carbohydrate NN cord-355239-fc52dn3v 225 3 moieties moiety NNS cord-355239-fc52dn3v 225 4 vary vary VBP cord-355239-fc52dn3v 225 5 , , , cord-355239-fc52dn3v 225 6 and and CC cord-355239-fc52dn3v 225 7 each each DT cord-355239-fc52dn3v 225 8 glycolipid glycolipid NN cord-355239-fc52dn3v 225 9 may may MD cord-355239-fc52dn3v 225 10 exhibit exhibit VB cord-355239-fc52dn3v 225 11 a a DT cord-355239-fc52dn3v 225 12 special special JJ cord-355239-fc52dn3v 225 13 function function NN cord-355239-fc52dn3v 225 14 , , , cord-355239-fc52dn3v 225 15 as as IN cord-355239-fc52dn3v 225 16 an an DT cord-355239-fc52dn3v 225 17 annular annular JJ cord-355239-fc52dn3v 225 18 lipid lipid NN cord-355239-fc52dn3v 225 19 , , , cord-355239-fc52dn3v 225 20 surface surface NN cord-355239-fc52dn3v 225 21 receptor receptor NN cord-355239-fc52dn3v 225 22 marker marker NN cord-355239-fc52dn3v 225 23 or or CC cord-355239-fc52dn3v 225 24 matrix matrix NN cord-355239-fc52dn3v 225 25 lipid lipid NN cord-355239-fc52dn3v 225 26 . . . cord-355239-fc52dn3v 226 1 For for IN cord-355239-fc52dn3v 226 2 brain brain NN cord-355239-fc52dn3v 226 3 and and CC cord-355239-fc52dn3v 226 4 neuronal neuronal JJ cord-355239-fc52dn3v 226 5 cells cell NNS cord-355239-fc52dn3v 226 6 , , , cord-355239-fc52dn3v 226 7 gangliosides ganglioside NNS cord-355239-fc52dn3v 226 8 ( ( -LRB- cord-355239-fc52dn3v 226 9 sialic sialic JJ cord-355239-fc52dn3v 226 10 acid acid NN cord-355239-fc52dn3v 226 11 - - HYPH cord-355239-fc52dn3v 226 12 bearing bear VBG cord-355239-fc52dn3v 226 13 glycolipids glycolipid NNS cord-355239-fc52dn3v 226 14 ) ) -RRB- cord-355239-fc52dn3v 226 15 are be VBP cord-355239-fc52dn3v 226 16 the the DT cord-355239-fc52dn3v 226 17 major major JJ cord-355239-fc52dn3v 226 18 cell cell NN cord-355239-fc52dn3v 226 19 surface surface NN cord-355239-fc52dn3v 226 20 determinants determinant NNS cord-355239-fc52dn3v 226 21 [ [ -LRB- cord-355239-fc52dn3v 226 22 69 69 CD cord-355239-fc52dn3v 226 23 ] ] -RRB- cord-355239-fc52dn3v 226 24 . . . cord-355239-fc52dn3v 227 1 Glycolipids glycolipids NN cord-355239-fc52dn3v 227 2 function function NN cord-355239-fc52dn3v 227 3 as as IN cord-355239-fc52dn3v 227 4 the the DT cord-355239-fc52dn3v 227 5 receptor receptor NN cord-355239-fc52dn3v 227 6 for for IN cord-355239-fc52dn3v 227 7 various various JJ cord-355239-fc52dn3v 227 8 biologic biologic JJ cord-355239-fc52dn3v 227 9 factors factor NNS cord-355239-fc52dn3v 227 10 and and CC cord-355239-fc52dn3v 227 11 also also RB cord-355239-fc52dn3v 227 12 as as IN cord-355239-fc52dn3v 227 13 the the DT cord-355239-fc52dn3v 227 14 receptor receptor NN cord-355239-fc52dn3v 227 15 for for IN cord-355239-fc52dn3v 227 16 various various JJ cord-355239-fc52dn3v 227 17 pathogens pathogen NNS cord-355239-fc52dn3v 227 18 . . . cord-355239-fc52dn3v 228 1 They -PRON- PRP cord-355239-fc52dn3v 228 2 are be VBP cord-355239-fc52dn3v 228 3 present present JJ cord-355239-fc52dn3v 228 4 at at IN cord-355239-fc52dn3v 228 5 the the DT cord-355239-fc52dn3v 228 6 undermost undermost JJ cord-355239-fc52dn3v 228 7 part part NN cord-355239-fc52dn3v 228 8 of of IN cord-355239-fc52dn3v 228 9 the the DT cord-355239-fc52dn3v 228 10 glycocalyx glycocalyx NNP cord-355239-fc52dn3v 228 11 . . . cord-355239-fc52dn3v 229 1 Pathogens pathogen NNS cord-355239-fc52dn3v 229 2 can can MD cord-355239-fc52dn3v 229 3 recognize recognize VB cord-355239-fc52dn3v 229 4 the the DT cord-355239-fc52dn3v 229 5 glycolipids glycolipid NNS cord-355239-fc52dn3v 229 6 , , , cord-355239-fc52dn3v 229 7 directly directly RB cord-355239-fc52dn3v 229 8 bind bind VB cord-355239-fc52dn3v 229 9 to to IN cord-355239-fc52dn3v 229 10 the the DT cord-355239-fc52dn3v 229 11 cell cell NN cord-355239-fc52dn3v 229 12 membrane membrane NN cord-355239-fc52dn3v 229 13 , , , cord-355239-fc52dn3v 229 14 and and CC cord-355239-fc52dn3v 229 15 invade invade VB cord-355239-fc52dn3v 229 16 the the DT cord-355239-fc52dn3v 229 17 host host NN cord-355239-fc52dn3v 229 18 cell cell NN cord-355239-fc52dn3v 229 19 . . . cord-355239-fc52dn3v 230 1 Glycolipids Glycolipids NNP cord-355239-fc52dn3v 230 2 also also RB cord-355239-fc52dn3v 230 3 function function VBP cord-355239-fc52dn3v 230 4 as as IN cord-355239-fc52dn3v 230 5 receptors receptor NNS cord-355239-fc52dn3v 230 6 for for IN cord-355239-fc52dn3v 230 7 certain certain JJ cord-355239-fc52dn3v 230 8 effector effector NN cord-355239-fc52dn3v 230 9 molecules molecule NNS cord-355239-fc52dn3v 230 10 , , , cord-355239-fc52dn3v 230 11 such such JJ cord-355239-fc52dn3v 230 12 as as IN cord-355239-fc52dn3v 230 13 bacterial bacterial JJ cord-355239-fc52dn3v 230 14 toxins toxin NNS cord-355239-fc52dn3v 230 15 , , , cord-355239-fc52dn3v 230 16 produced produce VBN cord-355239-fc52dn3v 230 17 by by IN cord-355239-fc52dn3v 230 18 pathogens pathogen NNS cord-355239-fc52dn3v 230 19 and and CC cord-355239-fc52dn3v 230 20 directly directly RB cord-355239-fc52dn3v 230 21 react react VB cord-355239-fc52dn3v 230 22 with with IN cord-355239-fc52dn3v 230 23 the the DT cord-355239-fc52dn3v 230 24 host host NN cord-355239-fc52dn3v 230 25 cell cell NN cord-355239-fc52dn3v 230 26 . . . cord-355239-fc52dn3v 231 1 For for IN cord-355239-fc52dn3v 231 2 example example NN cord-355239-fc52dn3v 231 3 , , , cord-355239-fc52dn3v 231 4 cholera cholera NN cord-355239-fc52dn3v 231 5 toxin toxin NN cord-355239-fc52dn3v 231 6 binds bind VBZ cord-355239-fc52dn3v 231 7 to to TO cord-355239-fc52dn3v 231 8 ganglioside ganglioside VB cord-355239-fc52dn3v 231 9 GM1 GM1 NNP cord-355239-fc52dn3v 231 10 [ [ -LRB- cord-355239-fc52dn3v 231 11 70 70 CD cord-355239-fc52dn3v 231 12 ] ] -RRB- cord-355239-fc52dn3v 231 13 . . . cord-355239-fc52dn3v 232 1 Thus thus RB cord-355239-fc52dn3v 232 2 , , , cord-355239-fc52dn3v 232 3 for for IN cord-355239-fc52dn3v 232 4 pathogens pathogen NNS cord-355239-fc52dn3v 232 5 living live VBG cord-355239-fc52dn3v 232 6 in in IN cord-355239-fc52dn3v 232 7 the the DT cord-355239-fc52dn3v 232 8 outer outer JJ cord-355239-fc52dn3v 232 9 mucus mucus NN cord-355239-fc52dn3v 232 10 layer layer NN cord-355239-fc52dn3v 232 11 , , , cord-355239-fc52dn3v 232 12 it -PRON- PRP cord-355239-fc52dn3v 232 13 is be VBZ cord-355239-fc52dn3v 232 14 difficult difficult JJ cord-355239-fc52dn3v 232 15 to to TO cord-355239-fc52dn3v 232 16 make make VB cord-355239-fc52dn3v 232 17 contact contact NN cord-355239-fc52dn3v 232 18 with with IN cord-355239-fc52dn3v 232 19 the the DT cord-355239-fc52dn3v 232 20 surface surface NN cord-355239-fc52dn3v 232 21 of of IN cord-355239-fc52dn3v 232 22 normal normal JJ cord-355239-fc52dn3v 232 23 epithelial epithelial JJ cord-355239-fc52dn3v 232 24 cells cell NNS cord-355239-fc52dn3v 232 25 because because IN cord-355239-fc52dn3v 232 26 of of IN cord-355239-fc52dn3v 232 27 the the DT cord-355239-fc52dn3v 232 28 huge huge JJ cord-355239-fc52dn3v 232 29 amount amount NN cord-355239-fc52dn3v 232 30 of of IN cord-355239-fc52dn3v 232 31 mucin mucin NN cord-355239-fc52dn3v 232 32 that that WDT cord-355239-fc52dn3v 232 33 functions function VBZ cord-355239-fc52dn3v 232 34 as as IN cord-355239-fc52dn3v 232 35 a a DT cord-355239-fc52dn3v 232 36 " " `` cord-355239-fc52dn3v 232 37 decoy decoy NN cord-355239-fc52dn3v 232 38 " " '' cord-355239-fc52dn3v 232 39 or or CC cord-355239-fc52dn3v 232 40 " " `` cord-355239-fc52dn3v 232 41 physical physical JJ cord-355239-fc52dn3v 232 42 barrier barrier NN cord-355239-fc52dn3v 232 43 " " '' cord-355239-fc52dn3v 232 44 . . . cord-355239-fc52dn3v 233 1 Mucosal Mucosal NNP cord-355239-fc52dn3v 233 2 pathogens pathogen NNS cord-355239-fc52dn3v 233 3 have have VBP cord-355239-fc52dn3v 233 4 , , , cord-355239-fc52dn3v 233 5 therefore therefore RB cord-355239-fc52dn3v 233 6 , , , cord-355239-fc52dn3v 233 7 developed develop VBN cord-355239-fc52dn3v 233 8 mechanisms mechanism NNS cord-355239-fc52dn3v 233 9 to to TO cord-355239-fc52dn3v 233 10 subvert subvert VB cord-355239-fc52dn3v 233 11 these these DT cord-355239-fc52dn3v 233 12 defense defense NN cord-355239-fc52dn3v 233 13 mechanisms mechanism NNS cord-355239-fc52dn3v 233 14 of of IN cord-355239-fc52dn3v 233 15 the the DT cord-355239-fc52dn3v 233 16 mucosal mucosal JJ cord-355239-fc52dn3v 233 17 layer layer NN cord-355239-fc52dn3v 233 18 . . . cord-355239-fc52dn3v 234 1 On on IN cord-355239-fc52dn3v 234 2 the the DT cord-355239-fc52dn3v 234 3 other other JJ cord-355239-fc52dn3v 234 4 hand hand NN cord-355239-fc52dn3v 234 5 , , , cord-355239-fc52dn3v 234 6 intestinal intestinal JJ cord-355239-fc52dn3v 234 7 M M NNP cord-355239-fc52dn3v 234 8 cells cell NNS cord-355239-fc52dn3v 234 9 , , , cord-355239-fc52dn3v 234 10 specifically specifically RB cord-355239-fc52dn3v 234 11 designed design VBN cord-355239-fc52dn3v 234 12 to to TO cord-355239-fc52dn3v 234 13 capture capture VB cord-355239-fc52dn3v 234 14 and and CC cord-355239-fc52dn3v 234 15 present present JJ cord-355239-fc52dn3v 234 16 microbes microbe NNS cord-355239-fc52dn3v 234 17 to to IN cord-355239-fc52dn3v 234 18 the the DT cord-355239-fc52dn3v 234 19 underlying underlying JJ cord-355239-fc52dn3v 234 20 lymphoid lymphoid JJ cord-355239-fc52dn3v 234 21 tissue tissue NN cord-355239-fc52dn3v 234 22 , , , cord-355239-fc52dn3v 234 23 can can MD cord-355239-fc52dn3v 234 24 be be VB cord-355239-fc52dn3v 234 25 regarded regard VBN cord-355239-fc52dn3v 234 26 as as IN cord-355239-fc52dn3v 234 27 a a DT cord-355239-fc52dn3v 234 28 " " `` cord-355239-fc52dn3v 234 29 hole hole NN cord-355239-fc52dn3v 234 30 " " '' cord-355239-fc52dn3v 234 31 in in IN cord-355239-fc52dn3v 234 32 the the DT cord-355239-fc52dn3v 234 33 mucin mucin NN cord-355239-fc52dn3v 234 34 barrier barrier NN cord-355239-fc52dn3v 234 35 . . . cord-355239-fc52dn3v 235 1 The the DT cord-355239-fc52dn3v 235 2 dome dome NN cord-355239-fc52dn3v 235 3 epithelium epithelium NN cord-355239-fc52dn3v 235 4 lacks lack VBZ cord-355239-fc52dn3v 235 5 goblet goblet NN cord-355239-fc52dn3v 235 6 cells cell NNS cord-355239-fc52dn3v 235 7 and and CC cord-355239-fc52dn3v 235 8 therefore therefore RB cord-355239-fc52dn3v 235 9 does do VBZ cord-355239-fc52dn3v 235 10 not not RB cord-355239-fc52dn3v 235 11 produce produce VB cord-355239-fc52dn3v 235 12 gel gel NN cord-355239-fc52dn3v 235 13 - - HYPH cord-355239-fc52dn3v 235 14 forming form VBG cord-355239-fc52dn3v 235 15 mucins mucin NNS cord-355239-fc52dn3v 235 16 . . . cord-355239-fc52dn3v 236 1 Their -PRON- PRP$ cord-355239-fc52dn3v 236 2 apical apical JJ cord-355239-fc52dn3v 236 3 cell cell NN cord-355239-fc52dn3v 236 4 surface surface NN cord-355239-fc52dn3v 236 5 has have VBZ cord-355239-fc52dn3v 236 6 only only RB cord-355239-fc52dn3v 236 7 sparse sparse JJ cord-355239-fc52dn3v 236 8 microvilli microvilli NN cord-355239-fc52dn3v 236 9 and and CC cord-355239-fc52dn3v 236 10 an an DT cord-355239-fc52dn3v 236 11 apparently apparently RB cord-355239-fc52dn3v 236 12 thin thin JJ cord-355239-fc52dn3v 236 13 glycocalyx glycocalyx NN cord-355239-fc52dn3v 236 14 [ [ -LRB- cord-355239-fc52dn3v 236 15 71 71 CD cord-355239-fc52dn3v 236 16 , , , cord-355239-fc52dn3v 236 17 72 72 CD cord-355239-fc52dn3v 236 18 ] ] -RRB- cord-355239-fc52dn3v 236 19 . . . cord-355239-fc52dn3v 237 1 M M NNP cord-355239-fc52dn3v 237 2 cells cell NNS cord-355239-fc52dn3v 237 3 are be VBP cord-355239-fc52dn3v 237 4 specialized specialized JJ cord-355239-fc52dn3v 237 5 epithelial epithelial JJ cord-355239-fc52dn3v 237 6 antigen antigen NN cord-355239-fc52dn3v 237 7 - - HYPH cord-355239-fc52dn3v 237 8 transporting transport VBG cord-355239-fc52dn3v 237 9 cells cell NNS cord-355239-fc52dn3v 237 10 that that WDT cord-355239-fc52dn3v 237 11 constitute constitute VBP cord-355239-fc52dn3v 237 12 a a DT cord-355239-fc52dn3v 237 13 minor minor JJ cord-355239-fc52dn3v 237 14 proportion proportion NN cord-355239-fc52dn3v 237 15 ( ( -LRB- cord-355239-fc52dn3v 237 16 5%~10 5%~10 CD cord-355239-fc52dn3v 237 17 % % NN cord-355239-fc52dn3v 237 18 in in IN cord-355239-fc52dn3v 237 19 humans human NNS cord-355239-fc52dn3v 237 20 and and CC cord-355239-fc52dn3v 237 21 mice mouse NNS cord-355239-fc52dn3v 237 22 ) ) -RRB- cord-355239-fc52dn3v 237 23 of of IN cord-355239-fc52dn3v 237 24 the the DT cord-355239-fc52dn3v 237 25 follicle follicle NN cord-355239-fc52dn3v 237 26 - - HYPH cord-355239-fc52dn3v 237 27 associated associate VBN cord-355239-fc52dn3v 237 28 epithelium epithelium NN cord-355239-fc52dn3v 237 29 that that WDT cord-355239-fc52dn3v 237 30 covers cover VBZ cord-355239-fc52dn3v 237 31 the the DT cord-355239-fc52dn3v 237 32 lymphoid lymphoid JJ cord-355239-fc52dn3v 237 33 follicles follicle NNS cord-355239-fc52dn3v 237 34 of of IN cord-355239-fc52dn3v 237 35 organized organized JJ cord-355239-fc52dn3v 237 36 gut gut NN cord-355239-fc52dn3v 237 37 - - HYPH cord-355239-fc52dn3v 237 38 associated associate VBN cord-355239-fc52dn3v 237 39 lymphoid lymphoid JJ cord-355239-fc52dn3v 237 40 tissue tissue NN cord-355239-fc52dn3v 237 41 such such JJ cord-355239-fc52dn3v 237 42 as as IN cord-355239-fc52dn3v 237 43 Peyer Peyer NNP cord-355239-fc52dn3v 237 44 's 's POS cord-355239-fc52dn3v 237 45 patches patch NNS cord-355239-fc52dn3v 237 46 [ [ -LRB- cord-355239-fc52dn3v 237 47 73 73 CD cord-355239-fc52dn3v 237 48 ] ] -RRB- cord-355239-fc52dn3v 237 49 [ [ -LRB- cord-355239-fc52dn3v 237 50 74 74 CD cord-355239-fc52dn3v 237 51 ] ] -RRB- cord-355239-fc52dn3v 237 52 [ [ -LRB- cord-355239-fc52dn3v 237 53 75 75 CD cord-355239-fc52dn3v 237 54 ] ] -RRB- cord-355239-fc52dn3v 237 55 [ [ -LRB- cord-355239-fc52dn3v 237 56 76 76 CD cord-355239-fc52dn3v 237 57 ] ] -RRB- cord-355239-fc52dn3v 237 58 . . . cord-355239-fc52dn3v 238 1 Glycoprotein glycoprotein NN cord-355239-fc52dn3v 238 2 2 2 CD cord-355239-fc52dn3v 238 3 ( ( -LRB- cord-355239-fc52dn3v 238 4 GP2 GP2 NNP cord-355239-fc52dn3v 238 5 ) ) -RRB- cord-355239-fc52dn3v 238 6 was be VBD cord-355239-fc52dn3v 238 7 identified identify VBN cord-355239-fc52dn3v 238 8 as as IN cord-355239-fc52dn3v 238 9 an an DT cord-355239-fc52dn3v 238 10 M M NNP cord-355239-fc52dn3v 238 11 cell cell NN cord-355239-fc52dn3v 238 12 - - HYPH cord-355239-fc52dn3v 238 13 specific specific JJ cord-355239-fc52dn3v 238 14 molecule molecule NN cord-355239-fc52dn3v 238 15 [ [ -LRB- cord-355239-fc52dn3v 238 16 77 77 CD cord-355239-fc52dn3v 238 17 ] ] -RRB- cord-355239-fc52dn3v 238 18 . . . cord-355239-fc52dn3v 239 1 The the DT cord-355239-fc52dn3v 239 2 GP2 GP2 NNP cord-355239-fc52dn3v 239 3 expressed express VBD cord-355239-fc52dn3v 239 4 on on IN cord-355239-fc52dn3v 239 5 M M NNP cord-355239-fc52dn3v 239 6 cells cell NNS cord-355239-fc52dn3v 239 7 functions function NNS cord-355239-fc52dn3v 239 8 as as IN cord-355239-fc52dn3v 239 9 a a DT cord-355239-fc52dn3v 239 10 bacterial bacterial JJ cord-355239-fc52dn3v 239 11 uptake uptake NN cord-355239-fc52dn3v 239 12 receptor receptor NN cord-355239-fc52dn3v 239 13 [ [ -LRB- cord-355239-fc52dn3v 239 14 77 77 CD cord-355239-fc52dn3v 239 15 ] ] -RRB- cord-355239-fc52dn3v 239 16 . . . cord-355239-fc52dn3v 240 1 GP2 GP2 NNP cord-355239-fc52dn3v 240 2 recognizes recognize VBZ cord-355239-fc52dn3v 240 3 FimH FimH NNP cord-355239-fc52dn3v 240 4 , , , cord-355239-fc52dn3v 240 5 a a DT cord-355239-fc52dn3v 240 6 major major JJ cord-355239-fc52dn3v 240 7 component component NN cord-355239-fc52dn3v 240 8 of of IN cord-355239-fc52dn3v 240 9 the the DT cord-355239-fc52dn3v 240 10 type type NN cord-355239-fc52dn3v 240 11 1 1 CD cord-355239-fc52dn3v 240 12 fimbriae fimbriae NN cord-355239-fc52dn3v 240 13 , , , cord-355239-fc52dn3v 240 14 which which WDT cord-355239-fc52dn3v 240 15 binds bind VBZ cord-355239-fc52dn3v 240 16 to to IN cord-355239-fc52dn3v 240 17 certain certain JJ cord-355239-fc52dn3v 240 18 glycoproteins glycoprotein NNS cord-355239-fc52dn3v 240 19 on on IN cord-355239-fc52dn3v 240 20 mammalian mammalian JJ cord-355239-fc52dn3v 240 21 cells cell NNS cord-355239-fc52dn3v 240 22 in in IN cord-355239-fc52dn3v 240 23 a a DT cord-355239-fc52dn3v 240 24 mannosedependent mannosedependent NN cord-355239-fc52dn3v 240 25 manner manner NN cord-355239-fc52dn3v 240 26 [ [ -LRB- cord-355239-fc52dn3v 240 27 78 78 CD cord-355239-fc52dn3v 240 28 ] ] -RRB- cord-355239-fc52dn3v 240 29 . . . cord-355239-fc52dn3v 241 1 Consequently consequently RB cord-355239-fc52dn3v 241 2 , , , cord-355239-fc52dn3v 241 3 even even RB cord-355239-fc52dn3v 241 4 though though IN cord-355239-fc52dn3v 241 5 M M NNP cord-355239-fc52dn3v 241 6 cells cell NNS cord-355239-fc52dn3v 241 7 constitute constitute VBP cord-355239-fc52dn3v 241 8 only only RB cord-355239-fc52dn3v 241 9 a a DT cord-355239-fc52dn3v 241 10 very very RB cord-355239-fc52dn3v 241 11 small small JJ cord-355239-fc52dn3v 241 12 percentage percentage NN cord-355239-fc52dn3v 241 13 of of IN cord-355239-fc52dn3v 241 14 mucosal mucosal JJ cord-355239-fc52dn3v 241 15 epithelial epithelial JJ cord-355239-fc52dn3v 241 16 cells cell NNS cord-355239-fc52dn3v 241 17 , , , cord-355239-fc52dn3v 241 18 they -PRON- PRP cord-355239-fc52dn3v 241 19 are be VBP cord-355239-fc52dn3v 241 20 the the DT cord-355239-fc52dn3v 241 21 major major JJ cord-355239-fc52dn3v 241 22 point point NN cord-355239-fc52dn3v 241 23 of of IN cord-355239-fc52dn3v 241 24 attachment attachment NN cord-355239-fc52dn3v 241 25 and/or and/or CC cord-355239-fc52dn3v 241 26 entry entry NN cord-355239-fc52dn3v 241 27 used use VBN cord-355239-fc52dn3v 241 28 by by IN cord-355239-fc52dn3v 241 29 numerous numerous JJ cord-355239-fc52dn3v 241 30 mucosal mucosal JJ cord-355239-fc52dn3v 241 31 pathogens pathogen NNS cord-355239-fc52dn3v 241 32 including include VBG cord-355239-fc52dn3v 241 33 bacteria bacteria NNS cord-355239-fc52dn3v 241 34 ( ( -LRB- cord-355239-fc52dn3v 241 35 e.g. e.g. RB cord-355239-fc52dn3v 241 36 , , , cord-355239-fc52dn3v 241 37 S. S. NNP cord-355239-fc52dn3v 241 38 typhimurium typhimurium NN cord-355239-fc52dn3v 241 39 , , , cord-355239-fc52dn3v 241 40 Shigella Shigella NNP cord-355239-fc52dn3v 241 41 flexneri flexneri NN cord-355239-fc52dn3v 241 42 , , , cord-355239-fc52dn3v 241 43 Yersinia Yersinia NNP cord-355239-fc52dn3v 241 44 enterocolitica enterocolitica NNP cord-355239-fc52dn3v 241 45 and and CC cord-355239-fc52dn3v 241 46 Vibrio Vibrio NNP cord-355239-fc52dn3v 241 47 cholerae cholerae NN cord-355239-fc52dn3v 241 48 ) ) -RRB- cord-355239-fc52dn3v 241 49 , , , cord-355239-fc52dn3v 241 50 viruses virus NNS cord-355239-fc52dn3v 241 51 ( ( -LRB- cord-355239-fc52dn3v 241 52 e.g. e.g. RB cord-355239-fc52dn3v 241 53 , , , cord-355239-fc52dn3v 241 54 reovirus reovirus NNP cord-355239-fc52dn3v 241 55 , , , cord-355239-fc52dn3v 241 56 HIV-1 HIV-1 NNP cord-355239-fc52dn3v 241 57 and and CC cord-355239-fc52dn3v 241 58 polio polio NN cord-355239-fc52dn3v 241 59 virus virus NN cord-355239-fc52dn3v 241 60 ) ) -RRB- cord-355239-fc52dn3v 241 61 and and CC cord-355239-fc52dn3v 241 62 parasites parasite NNS cord-355239-fc52dn3v 241 63 ( ( -LRB- cord-355239-fc52dn3v 241 64 e.g. e.g. RB cord-355239-fc52dn3v 241 65 , , , cord-355239-fc52dn3v 241 66 Cryptosporidia Cryptosporidia NNP cord-355239-fc52dn3v 241 67 ) ) -RRB- cord-355239-fc52dn3v 241 68 [ [ -LRB- cord-355239-fc52dn3v 241 69 72 72 CD cord-355239-fc52dn3v 241 70 , , , cord-355239-fc52dn3v 241 71 79 79 CD cord-355239-fc52dn3v 241 72 , , , cord-355239-fc52dn3v 241 73 80 80 CD cord-355239-fc52dn3v 241 74 ] ] -RRB- cord-355239-fc52dn3v 241 75 . . . cord-355239-fc52dn3v 242 1 During during IN cord-355239-fc52dn3v 242 2 cell cell NN cord-355239-fc52dn3v 242 3 - - HYPH cord-355239-fc52dn3v 242 4 pathogen pathogen NN cord-355239-fc52dn3v 242 5 interactions interaction NNS cord-355239-fc52dn3v 242 6 ( ( -LRB- cord-355239-fc52dn3v 242 7 i.e. i.e. FW cord-355239-fc52dn3v 242 8 , , , cord-355239-fc52dn3v 242 9 infection infection NN cord-355239-fc52dn3v 242 10 and/or and/or CC cord-355239-fc52dn3v 242 11 invasion invasion NN cord-355239-fc52dn3v 242 12 ) ) -RRB- cord-355239-fc52dn3v 242 13 , , , cord-355239-fc52dn3v 242 14 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 242 15 function function VBP cord-355239-fc52dn3v 242 16 as as IN cord-355239-fc52dn3v 242 17 receptors receptor NNS cord-355239-fc52dn3v 242 18 for for IN cord-355239-fc52dn3v 242 19 various various JJ cord-355239-fc52dn3v 242 20 pathogens pathogen NNS cord-355239-fc52dn3v 242 21 . . . cord-355239-fc52dn3v 243 1 On on IN cord-355239-fc52dn3v 243 2 the the DT cord-355239-fc52dn3v 243 3 other other JJ cord-355239-fc52dn3v 243 4 hand hand NN cord-355239-fc52dn3v 243 5 , , , cord-355239-fc52dn3v 243 6 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 243 7 ( ( -LRB- cord-355239-fc52dn3v 243 8 glycoconjugates glycoconjugate NNS cord-355239-fc52dn3v 243 9 ) ) -RRB- cord-355239-fc52dn3v 243 10 can can MD cord-355239-fc52dn3v 243 11 also also RB cord-355239-fc52dn3v 243 12 function function VB cord-355239-fc52dn3v 243 13 as as IN cord-355239-fc52dn3v 243 14 a a DT cord-355239-fc52dn3v 243 15 barrier barrier NN cord-355239-fc52dn3v 243 16 to to IN cord-355239-fc52dn3v 243 17 infection infection NN cord-355239-fc52dn3v 243 18 . . . cord-355239-fc52dn3v 244 1 On on IN cord-355239-fc52dn3v 244 2 the the DT cord-355239-fc52dn3v 244 3 surface surface NN cord-355239-fc52dn3v 244 4 of of IN cord-355239-fc52dn3v 244 5 mucosal mucosal JJ cord-355239-fc52dn3v 244 6 tissue tissue NN cord-355239-fc52dn3v 244 7 , , , cord-355239-fc52dn3v 244 8 the the DT cord-355239-fc52dn3v 244 9 glycocalyx glycocalyx NNP cord-355239-fc52dn3v 244 10 physically physically RB cord-355239-fc52dn3v 244 11 prevents prevent VBZ cord-355239-fc52dn3v 244 12 microbes microbe NNS cord-355239-fc52dn3v 244 13 from from IN cord-355239-fc52dn3v 244 14 accessing access VBG cord-355239-fc52dn3v 244 15 the the DT cord-355239-fc52dn3v 244 16 cell cell NN cord-355239-fc52dn3v 244 17 membrane membrane NN cord-355239-fc52dn3v 244 18 . . . cord-355239-fc52dn3v 245 1 Some some DT cord-355239-fc52dn3v 245 2 glycoconjugates glycoconjugate NNS cord-355239-fc52dn3v 245 3 , , , cord-355239-fc52dn3v 245 4 a a DT cord-355239-fc52dn3v 245 5 component component NN cord-355239-fc52dn3v 245 6 of of IN cord-355239-fc52dn3v 245 7 the the DT cord-355239-fc52dn3v 245 8 glycocalyx glycocalyx NNP cord-355239-fc52dn3v 245 9 , , , cord-355239-fc52dn3v 245 10 contain contain VBP cord-355239-fc52dn3v 245 11 carbohydrate carbohydrate NN cord-355239-fc52dn3v 245 12 structures structure NNS cord-355239-fc52dn3v 245 13 that that WDT cord-355239-fc52dn3v 245 14 are be VBP cord-355239-fc52dn3v 245 15 recognized recognize VBN cord-355239-fc52dn3v 245 16 by by IN cord-355239-fc52dn3v 245 17 pathogens pathogen NNS cord-355239-fc52dn3v 245 18 . . . cord-355239-fc52dn3v 246 1 Mucins mucin NNS cord-355239-fc52dn3v 246 2 often often RB cord-355239-fc52dn3v 246 3 contain contain VBP cord-355239-fc52dn3v 246 4 oligosaccharide oligosaccharide JJ cord-355239-fc52dn3v 246 5 moieties moiety NNS cord-355239-fc52dn3v 246 6 that that WDT cord-355239-fc52dn3v 246 7 correspond correspond VBP cord-355239-fc52dn3v 246 8 to to IN cord-355239-fc52dn3v 246 9 the the DT cord-355239-fc52dn3v 246 10 receptor receptor NN cord-355239-fc52dn3v 246 11 for for IN cord-355239-fc52dn3v 246 12 various various JJ cord-355239-fc52dn3v 246 13 pathogens pathogen NNS cord-355239-fc52dn3v 246 14 . . . cord-355239-fc52dn3v 247 1 On on IN cord-355239-fc52dn3v 247 2 the the DT cord-355239-fc52dn3v 247 3 surface surface NN cord-355239-fc52dn3v 247 4 of of IN cord-355239-fc52dn3v 247 5 the the DT cord-355239-fc52dn3v 247 6 mucosal mucosal JJ cord-355239-fc52dn3v 247 7 layer layer NN cord-355239-fc52dn3v 247 8 , , , cord-355239-fc52dn3v 247 9 microbes microbe NNS cord-355239-fc52dn3v 247 10 binds bind VBZ cord-355239-fc52dn3v 247 11 to to IN cord-355239-fc52dn3v 247 12 these these DT cord-355239-fc52dn3v 247 13 receptor receptor NN cord-355239-fc52dn3v 247 14 moieties moiety NNS cord-355239-fc52dn3v 247 15 and and CC cord-355239-fc52dn3v 247 16 are be VBP cord-355239-fc52dn3v 247 17 captured capture VBN cord-355239-fc52dn3v 247 18 at at IN cord-355239-fc52dn3v 247 19 the the DT cord-355239-fc52dn3v 247 20 mucus mucus NN cord-355239-fc52dn3v 247 21 layer layer NN cord-355239-fc52dn3v 247 22 , , , cord-355239-fc52dn3v 247 23 which which WDT cord-355239-fc52dn3v 247 24 consequently consequently RB cord-355239-fc52dn3v 247 25 blocks block VBZ cord-355239-fc52dn3v 247 26 the the DT cord-355239-fc52dn3v 247 27 infection infection NN cord-355239-fc52dn3v 247 28 . . . cord-355239-fc52dn3v 248 1 Moreover moreover RB cord-355239-fc52dn3v 248 2 , , , cord-355239-fc52dn3v 248 3 when when WRB cord-355239-fc52dn3v 248 4 secretory secretory JJ cord-355239-fc52dn3v 248 5 mucins mucin NNS cord-355239-fc52dn3v 248 6 containing contain VBG cord-355239-fc52dn3v 248 7 receptor receptor NN cord-355239-fc52dn3v 248 8 carbohydrate carbohydrate NN cord-355239-fc52dn3v 248 9 structures structure NNS cord-355239-fc52dn3v 248 10 " " `` cord-355239-fc52dn3v 248 11 trap trap NN cord-355239-fc52dn3v 248 12 " " '' cord-355239-fc52dn3v 248 13 pathogens pathogen NNS cord-355239-fc52dn3v 248 14 , , , cord-355239-fc52dn3v 248 15 the the DT cord-355239-fc52dn3v 248 16 pathogens pathogen NNS cord-355239-fc52dn3v 248 17 are be VBP cord-355239-fc52dn3v 248 18 also also RB cord-355239-fc52dn3v 248 19 carried carry VBN cord-355239-fc52dn3v 248 20 away away RB cord-355239-fc52dn3v 248 21 . . . cord-355239-fc52dn3v 249 1 M M NNP cord-355239-fc52dn3v 249 2 cells cell NNS cord-355239-fc52dn3v 249 3 are be VBP cord-355239-fc52dn3v 249 4 specialized specialized JJ cord-355239-fc52dn3v 249 5 epithelial epithelial JJ cord-355239-fc52dn3v 249 6 antigentransporting antigentransporting NN cord-355239-fc52dn3v 249 7 cells cell NNS cord-355239-fc52dn3v 249 8 scattered scatter VBN cord-355239-fc52dn3v 249 9 in in IN cord-355239-fc52dn3v 249 10 the the DT cord-355239-fc52dn3v 249 11 follicle follicle NN cord-355239-fc52dn3v 249 12 - - HYPH cord-355239-fc52dn3v 249 13 associated associate VBN cord-355239-fc52dn3v 249 14 epithelium epithelium NN cord-355239-fc52dn3v 249 15 that that WDT cord-355239-fc52dn3v 249 16 covers cover VBZ cord-355239-fc52dn3v 249 17 the the DT cord-355239-fc52dn3v 249 18 gut gut NN cord-355239-fc52dn3v 249 19 lymphoid lymphoid NN cord-355239-fc52dn3v 249 20 follicles follicle NNS cord-355239-fc52dn3v 249 21 such such JJ cord-355239-fc52dn3v 249 22 as as IN cord-355239-fc52dn3v 249 23 Peyer Peyer NNP cord-355239-fc52dn3v 249 24 's 's POS cord-355239-fc52dn3v 249 25 patches patch NNS cord-355239-fc52dn3v 249 26 . . . cord-355239-fc52dn3v 250 1 M m NN cord-355239-fc52dn3v 250 2 cells cell NNS cord-355239-fc52dn3v 250 3 can can MD cord-355239-fc52dn3v 250 4 efficiently efficiently RB cord-355239-fc52dn3v 250 5 engulf engulf VB cord-355239-fc52dn3v 250 6 particles particle NNS cord-355239-fc52dn3v 250 7 as as RB cord-355239-fc52dn3v 250 8 large large JJ cord-355239-fc52dn3v 250 9 as as IN cord-355239-fc52dn3v 250 10 bacteria bacteria NNS cord-355239-fc52dn3v 250 11 ; ; : cord-355239-fc52dn3v 250 12 however however RB cord-355239-fc52dn3v 250 13 , , , cord-355239-fc52dn3v 250 14 the the DT cord-355239-fc52dn3v 250 15 mucus mucus NN cord-355239-fc52dn3v 250 16 layer layer NN cord-355239-fc52dn3v 250 17 of of IN cord-355239-fc52dn3v 250 18 M M NNP cord-355239-fc52dn3v 250 19 cells cell NNS cord-355239-fc52dn3v 250 20 and and CC cord-355239-fc52dn3v 250 21 the the DT cord-355239-fc52dn3v 250 22 surrounding surround VBG cord-355239-fc52dn3v 250 23 area area NN cord-355239-fc52dn3v 250 24 is be VBZ cord-355239-fc52dn3v 250 25 relatively relatively RB cord-355239-fc52dn3v 250 26 thin thin JJ cord-355239-fc52dn3v 250 27 . . . cord-355239-fc52dn3v 251 1 Glycoconjugates glycoconjugate NNS cord-355239-fc52dn3v 251 2 such such JJ cord-355239-fc52dn3v 251 3 as as IN cord-355239-fc52dn3v 251 4 GP2 GP2 NNP cord-355239-fc52dn3v 251 5 are be VBP cord-355239-fc52dn3v 251 6 expressed express VBN cord-355239-fc52dn3v 251 7 on on IN cord-355239-fc52dn3v 251 8 the the DT cord-355239-fc52dn3v 251 9 surface surface NN cord-355239-fc52dn3v 251 10 of of IN cord-355239-fc52dn3v 251 11 M M NNP cord-355239-fc52dn3v 251 12 cells cell NNS cord-355239-fc52dn3v 251 13 and and CC cord-355239-fc52dn3v 251 14 function function VBP cord-355239-fc52dn3v 251 15 as as IN cord-355239-fc52dn3v 251 16 receptors receptor NNS cord-355239-fc52dn3v 251 17 for for IN cord-355239-fc52dn3v 251 18 bacterial bacterial JJ cord-355239-fc52dn3v 251 19 attachment attachment NN cord-355239-fc52dn3v 251 20 [ [ -LRB- cord-355239-fc52dn3v 251 21 74 74 CD cord-355239-fc52dn3v 251 22 ] ] -RRB- cord-355239-fc52dn3v 251 23 . . . cord-355239-fc52dn3v 252 1 In in IN cord-355239-fc52dn3v 252 2 the the DT cord-355239-fc52dn3v 252 3 case case NN cord-355239-fc52dn3v 252 4 of of IN cord-355239-fc52dn3v 252 5 the the DT cord-355239-fc52dn3v 252 6 host host NN cord-355239-fc52dn3v 252 7 - - HYPH cord-355239-fc52dn3v 252 8 parasite parasite NN cord-355239-fc52dn3v 252 9 interaction interaction NN cord-355239-fc52dn3v 252 10 , , , cord-355239-fc52dn3v 252 11 the the DT cord-355239-fc52dn3v 252 12 various various JJ cord-355239-fc52dn3v 252 13 kinds kind NNS cord-355239-fc52dn3v 252 14 of of IN cord-355239-fc52dn3v 252 15 glycoconjugates glycoconjugate NNS cord-355239-fc52dn3v 252 16 sometimes sometimes RB cord-355239-fc52dn3v 252 17 function function VBP cord-355239-fc52dn3v 252 18 as as IN cord-355239-fc52dn3v 252 19 receptors receptor NNS cord-355239-fc52dn3v 252 20 for for IN cord-355239-fc52dn3v 252 21 the the DT cord-355239-fc52dn3v 252 22 invading invade VBG cord-355239-fc52dn3v 252 23 pathogens pathogen NNS cord-355239-fc52dn3v 252 24 , , , cord-355239-fc52dn3v 252 25 but but CC cord-355239-fc52dn3v 252 26 they -PRON- PRP cord-355239-fc52dn3v 252 27 can can MD cord-355239-fc52dn3v 252 28 also also RB cord-355239-fc52dn3v 252 29 function function VB cord-355239-fc52dn3v 252 30 as as IN cord-355239-fc52dn3v 252 31 barriers barrier NNS cord-355239-fc52dn3v 252 32 48 48 CD cord-355239-fc52dn3v 252 33 Tropical Tropical NNP cord-355239-fc52dn3v 252 34 Medicine Medicine NNP cord-355239-fc52dn3v 252 35 and and CC cord-355239-fc52dn3v 252 36 Health Health NNP cord-355239-fc52dn3v 252 37 Vol Vol NNP cord-355239-fc52dn3v 252 38 . . . cord-355239-fc52dn3v 253 1 43 43 CD cord-355239-fc52dn3v 253 2 No.1 no.1 NN cord-355239-fc52dn3v 253 3 , , , cord-355239-fc52dn3v 253 4 2015 2015 CD cord-355239-fc52dn3v 253 5 and and CC cord-355239-fc52dn3v 253 6 traps trap NNS cord-355239-fc52dn3v 253 7 for for IN cord-355239-fc52dn3v 253 8 the the DT cord-355239-fc52dn3v 253 9 host host NN cord-355239-fc52dn3v 253 10 defense defense NN cord-355239-fc52dn3v 253 11 system system NN cord-355239-fc52dn3v 253 12 . . . cord-355239-fc52dn3v 254 1 In in IN cord-355239-fc52dn3v 254 2 recent recent JJ cord-355239-fc52dn3v 254 3 years year NNS cord-355239-fc52dn3v 254 4 , , , cord-355239-fc52dn3v 254 5 the the DT cord-355239-fc52dn3v 254 6 damage damage NN cord-355239-fc52dn3v 254 7 caused cause VBN cord-355239-fc52dn3v 254 8 by by IN cord-355239-fc52dn3v 254 9 enteric enteric JJ cord-355239-fc52dn3v 254 10 pathogens pathogen NNS cord-355239-fc52dn3v 254 11 , , , cord-355239-fc52dn3v 254 12 especially especially RB cord-355239-fc52dn3v 254 13 norovirus norovirus NN cord-355239-fc52dn3v 254 14 and and CC cord-355239-fc52dn3v 254 15 Salmonella Salmonella NNP cord-355239-fc52dn3v 254 16 , , , cord-355239-fc52dn3v 254 17 has have VBZ cord-355239-fc52dn3v 254 18 expanded expand VBN cord-355239-fc52dn3v 254 19 through through IN cord-355239-fc52dn3v 254 20 the the DT cord-355239-fc52dn3v 254 21 food food NN cord-355239-fc52dn3v 254 22 chain chain NN cord-355239-fc52dn3v 254 23 [ [ -LRB- cord-355239-fc52dn3v 254 24 4 4 CD cord-355239-fc52dn3v 254 25 , , , cord-355239-fc52dn3v 254 26 5 5 CD cord-355239-fc52dn3v 254 27 , , , cord-355239-fc52dn3v 254 28 81 81 CD cord-355239-fc52dn3v 254 29 ] ] -RRB- cord-355239-fc52dn3v 254 30 . . . cord-355239-fc52dn3v 255 1 These these DT cord-355239-fc52dn3v 255 2 pathogens pathogen NNS cord-355239-fc52dn3v 255 3 cause cause VBP cord-355239-fc52dn3v 255 4 food food NN cord-355239-fc52dn3v 255 5 poisoning poisoning NN cord-355239-fc52dn3v 255 6 in in IN cord-355239-fc52dn3v 255 7 humans human NNS cord-355239-fc52dn3v 255 8 and and CC cord-355239-fc52dn3v 255 9 gastrointestinal gastrointestinal JJ cord-355239-fc52dn3v 255 10 diseases disease NNS cord-355239-fc52dn3v 255 11 in in IN cord-355239-fc52dn3v 255 12 animals animal NNS cord-355239-fc52dn3v 255 13 all all RB cord-355239-fc52dn3v 255 14 over over IN cord-355239-fc52dn3v 255 15 the the DT cord-355239-fc52dn3v 255 16 world world NN cord-355239-fc52dn3v 255 17 . . . cord-355239-fc52dn3v 256 1 Even even RB cord-355239-fc52dn3v 256 2 today today NN cord-355239-fc52dn3v 256 3 , , , cord-355239-fc52dn3v 256 4 they -PRON- PRP cord-355239-fc52dn3v 256 5 are be VBP cord-355239-fc52dn3v 256 6 often often RB cord-355239-fc52dn3v 256 7 responsible responsible JJ cord-355239-fc52dn3v 256 8 for for IN cord-355239-fc52dn3v 256 9 large large JJ cord-355239-fc52dn3v 256 10 - - HYPH cord-355239-fc52dn3v 256 11 scale scale NN cord-355239-fc52dn3v 256 12 outbreaks outbreak NNS cord-355239-fc52dn3v 256 13 of of IN cord-355239-fc52dn3v 256 14 food food NN cord-355239-fc52dn3v 256 15 poisoning poisoning NN cord-355239-fc52dn3v 256 16 . . . cord-355239-fc52dn3v 257 1 Therefore therefore RB cord-355239-fc52dn3v 257 2 , , , cord-355239-fc52dn3v 257 3 the the DT cord-355239-fc52dn3v 257 4 prevention prevention NN cord-355239-fc52dn3v 257 5 and and CC cord-355239-fc52dn3v 257 6 treatment treatment NN cord-355239-fc52dn3v 257 7 of of IN cord-355239-fc52dn3v 257 8 infections infection NNS cord-355239-fc52dn3v 257 9 caused cause VBN cord-355239-fc52dn3v 257 10 by by IN cord-355239-fc52dn3v 257 11 these these DT cord-355239-fc52dn3v 257 12 pathogens pathogen NNS cord-355239-fc52dn3v 257 13 is be VBZ cord-355239-fc52dn3v 257 14 essential essential JJ cord-355239-fc52dn3v 257 15 . . . cord-355239-fc52dn3v 258 1 In in IN cord-355239-fc52dn3v 258 2 this this DT cord-355239-fc52dn3v 258 3 review review NN cord-355239-fc52dn3v 258 4 , , , cord-355239-fc52dn3v 258 5 we -PRON- PRP cord-355239-fc52dn3v 258 6 discussed discuss VBD cord-355239-fc52dn3v 258 7 the the DT cord-355239-fc52dn3v 258 8 interaction interaction NN cord-355239-fc52dn3v 258 9 between between IN cord-355239-fc52dn3v 258 10 host host NN cord-355239-fc52dn3v 258 11 cells cell NNS cord-355239-fc52dn3v 258 12 and and CC cord-355239-fc52dn3v 258 13 microbes microbe NNS cord-355239-fc52dn3v 258 14 such such JJ cord-355239-fc52dn3v 258 15 as as IN cord-355239-fc52dn3v 258 16 viruses virus NNS cord-355239-fc52dn3v 258 17 , , , cord-355239-fc52dn3v 258 18 bacteria bacteria NNS cord-355239-fc52dn3v 258 19 and and CC cord-355239-fc52dn3v 258 20 protozoa protozoan NNS cord-355239-fc52dn3v 258 21 that that WDT cord-355239-fc52dn3v 258 22 involve involve VBP cord-355239-fc52dn3v 258 23 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 258 24 such such JJ cord-355239-fc52dn3v 258 25 as as IN cord-355239-fc52dn3v 258 26 sialic sialic JJ cord-355239-fc52dn3v 258 27 acids acid NNS cord-355239-fc52dn3v 258 28 , , , cord-355239-fc52dn3v 258 29 heparan heparan NN cord-355239-fc52dn3v 258 30 sulfate sulfate NN cord-355239-fc52dn3v 258 31 , , , cord-355239-fc52dn3v 258 32 and and CC cord-355239-fc52dn3v 258 33 the the DT cord-355239-fc52dn3v 258 34 carbohydrate carbohydrate NN cord-355239-fc52dn3v 258 35 moieties moiety NNS cord-355239-fc52dn3v 258 36 of of IN cord-355239-fc52dn3v 258 37 ABH ABH NNP cord-355239-fc52dn3v 258 38 and and CC cord-355239-fc52dn3v 258 39 Lewis Lewis NNP cord-355239-fc52dn3v 258 40 antigens antigen NNS cord-355239-fc52dn3v 258 41 , , , cord-355239-fc52dn3v 258 42 mannose mannose NN cord-355239-fc52dn3v 258 43 components component NNS cord-355239-fc52dn3v 258 44 , , , cord-355239-fc52dn3v 258 45 ECMs ECMs NNP cord-355239-fc52dn3v 258 46 and and CC cord-355239-fc52dn3v 258 47 Le Le NNP cord-355239-fc52dn3v 258 48 X X NNP cord-355239-fc52dn3v 258 49 . . . cord-355239-fc52dn3v 259 1 The the DT cord-355239-fc52dn3v 259 2 development development NN cord-355239-fc52dn3v 259 3 and and CC cord-355239-fc52dn3v 259 4 use use NN cord-355239-fc52dn3v 259 5 of of IN cord-355239-fc52dn3v 259 6 drugs drug NNS cord-355239-fc52dn3v 259 7 that that WDT cord-355239-fc52dn3v 259 8 target target VBP cord-355239-fc52dn3v 259 9 these these DT cord-355239-fc52dn3v 259 10 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 259 11 is be VBZ cord-355239-fc52dn3v 259 12 anticipated anticipate VBN cord-355239-fc52dn3v 259 13 , , , cord-355239-fc52dn3v 259 14 even even RB cord-355239-fc52dn3v 259 15 though though IN cord-355239-fc52dn3v 259 16 the the DT cord-355239-fc52dn3v 259 17 microbes microbe NNS cord-355239-fc52dn3v 259 18 vary vary VBP cord-355239-fc52dn3v 259 19 widely widely RB cord-355239-fc52dn3v 259 20 and and CC cord-355239-fc52dn3v 259 21 have have VBP cord-355239-fc52dn3v 259 22 different different JJ cord-355239-fc52dn3v 259 23 modes mode NNS cord-355239-fc52dn3v 259 24 of of IN cord-355239-fc52dn3v 259 25 infection infection NN cord-355239-fc52dn3v 259 26 . . . cord-355239-fc52dn3v 260 1 Accordingly accordingly RB cord-355239-fc52dn3v 260 2 , , , cord-355239-fc52dn3v 260 3 when when WRB cord-355239-fc52dn3v 260 4 an an DT cord-355239-fc52dn3v 260 5 anti anti JJ cord-355239-fc52dn3v 260 6 - - JJ cord-355239-fc52dn3v 260 7 microbial microbial JJ cord-355239-fc52dn3v 260 8 drug drug NN cord-355239-fc52dn3v 260 9 is be VBZ cord-355239-fc52dn3v 260 10 developed develop VBN cord-355239-fc52dn3v 260 11 on on IN cord-355239-fc52dn3v 260 12 the the DT cord-355239-fc52dn3v 260 13 basis basis NN cord-355239-fc52dn3v 260 14 of of IN cord-355239-fc52dn3v 260 15 the the DT cord-355239-fc52dn3v 260 16 interaction interaction NN cord-355239-fc52dn3v 260 17 between between IN cord-355239-fc52dn3v 260 18 a a DT cord-355239-fc52dn3v 260 19 microbe microbe NN cord-355239-fc52dn3v 260 20 and and CC cord-355239-fc52dn3v 260 21 a a DT cord-355239-fc52dn3v 260 22 carbohydrate carbohydrate NN cord-355239-fc52dn3v 260 23 , , , cord-355239-fc52dn3v 260 24 host host NN cord-355239-fc52dn3v 260 25 cell cell NN cord-355239-fc52dn3v 260 26 modification modification NN cord-355239-fc52dn3v 260 27 of of IN cord-355239-fc52dn3v 260 28 the the DT cord-355239-fc52dn3v 260 29 drug drug NN cord-355239-fc52dn3v 260 30 's 's POS cord-355239-fc52dn3v 260 31 structure structure NN cord-355239-fc52dn3v 260 32 and/or and/or CC cord-355239-fc52dn3v 260 33 inhibition inhibition NN cord-355239-fc52dn3v 260 34 of of IN cord-355239-fc52dn3v 260 35 the the DT cord-355239-fc52dn3v 260 36 mode mode NN cord-355239-fc52dn3v 260 37 of of IN cord-355239-fc52dn3v 260 38 infection infection NN cord-355239-fc52dn3v 260 39 will will MD cord-355239-fc52dn3v 260 40 need need VB cord-355239-fc52dn3v 260 41 to to TO cord-355239-fc52dn3v 260 42 be be VB cord-355239-fc52dn3v 260 43 individualized individualize VBN cord-355239-fc52dn3v 260 44 while while IN cord-355239-fc52dn3v 260 45 still still RB cord-355239-fc52dn3v 260 46 taking take VBG cord-355239-fc52dn3v 260 47 advantage advantage NN cord-355239-fc52dn3v 260 48 of of IN cord-355239-fc52dn3v 260 49 the the DT cord-355239-fc52dn3v 260 50 similarities similarity NNS cord-355239-fc52dn3v 260 51 between between IN cord-355239-fc52dn3v 260 52 interactions interaction NNS cord-355239-fc52dn3v 260 53 . . . cord-355239-fc52dn3v 261 1 Moreover moreover RB cord-355239-fc52dn3v 261 2 , , , cord-355239-fc52dn3v 261 3 the the DT cord-355239-fc52dn3v 261 4 host host NN cord-355239-fc52dn3v 261 5 gastrointestinal gastrointestinal JJ cord-355239-fc52dn3v 261 6 tract tract NN cord-355239-fc52dn3v 261 7 cell cell NN cord-355239-fc52dn3v 261 8 surface surface NN cord-355239-fc52dn3v 261 9 , , , cord-355239-fc52dn3v 261 10 which which WDT cord-355239-fc52dn3v 261 11 is be VBZ cord-355239-fc52dn3v 261 12 the the DT cord-355239-fc52dn3v 261 13 object object NN cord-355239-fc52dn3v 261 14 of of IN cord-355239-fc52dn3v 261 15 microbial microbial JJ cord-355239-fc52dn3v 261 16 infection infection NN cord-355239-fc52dn3v 261 17 , , , cord-355239-fc52dn3v 261 18 is be VBZ cord-355239-fc52dn3v 261 19 composed compose VBN cord-355239-fc52dn3v 261 20 of of IN cord-355239-fc52dn3v 261 21 glycoproteins glycoprotein NNS cord-355239-fc52dn3v 261 22 , , , cord-355239-fc52dn3v 261 23 glycolipids glycolipid NNS cord-355239-fc52dn3v 261 24 , , , cord-355239-fc52dn3v 261 25 and and CC cord-355239-fc52dn3v 261 26 proteoglycans proteoglycan NNS cord-355239-fc52dn3v 261 27 . . . cord-355239-fc52dn3v 262 1 These these DT cord-355239-fc52dn3v 262 2 molecules molecule NNS cord-355239-fc52dn3v 262 3 are be VBP cord-355239-fc52dn3v 262 4 potential potential JJ cord-355239-fc52dn3v 262 5 targets target NNS cord-355239-fc52dn3v 262 6 for for IN cord-355239-fc52dn3v 262 7 carbohydrate carbohydrate NN cord-355239-fc52dn3v 262 8 drugs drug NNS cord-355239-fc52dn3v 262 9 used use VBN cord-355239-fc52dn3v 262 10 in in IN cord-355239-fc52dn3v 262 11 the the DT cord-355239-fc52dn3v 262 12 treatment treatment NN cord-355239-fc52dn3v 262 13 of of IN cord-355239-fc52dn3v 262 14 infectious infectious JJ cord-355239-fc52dn3v 262 15 diseases disease NNS cord-355239-fc52dn3v 262 16 . . . cord-355239-fc52dn3v 263 1 Oseltamivir Oseltamivir NNP cord-355239-fc52dn3v 263 2 and and CC cord-355239-fc52dn3v 263 3 zanamivir zanamivir NNP cord-355239-fc52dn3v 263 4 are be VBP cord-355239-fc52dn3v 263 5 neuraminidase neuraminidase NN cord-355239-fc52dn3v 263 6 inhibitors inhibitor NNS cord-355239-fc52dn3v 263 7 that that WDT cord-355239-fc52dn3v 263 8 competitively competitively RB cord-355239-fc52dn3v 263 9 inhibit inhibit VBP cord-355239-fc52dn3v 263 10 the the DT cord-355239-fc52dn3v 263 11 activity activity NN cord-355239-fc52dn3v 263 12 of of IN cord-355239-fc52dn3v 263 13 the the DT cord-355239-fc52dn3v 263 14 viral viral JJ cord-355239-fc52dn3v 263 15 neuraminidase neuraminidase NN cord-355239-fc52dn3v 263 16 on on IN cord-355239-fc52dn3v 263 17 the the DT cord-355239-fc52dn3v 263 18 sialic sialic JJ cord-355239-fc52dn3v 263 19 acid acid NN cord-355239-fc52dn3v 263 20 that that WDT cord-355239-fc52dn3v 263 21 is be VBZ cord-355239-fc52dn3v 263 22 found find VBN cord-355239-fc52dn3v 263 23 on on IN cord-355239-fc52dn3v 263 24 glycoproteins glycoprotein NNS cord-355239-fc52dn3v 263 25 on on IN cord-355239-fc52dn3v 263 26 the the DT cord-355239-fc52dn3v 263 27 surface surface NN cord-355239-fc52dn3v 263 28 of of IN cord-355239-fc52dn3v 263 29 host host NN cord-355239-fc52dn3v 263 30 cells cell NNS cord-355239-fc52dn3v 263 31 [ [ -LRB- cord-355239-fc52dn3v 263 32 82 82 CD cord-355239-fc52dn3v 263 33 ] ] -RRB- cord-355239-fc52dn3v 263 34 . . . cord-355239-fc52dn3v 264 1 By by IN cord-355239-fc52dn3v 264 2 blocking block VBG cord-355239-fc52dn3v 264 3 the the DT cord-355239-fc52dn3v 264 4 activity activity NN cord-355239-fc52dn3v 264 5 of of IN cord-355239-fc52dn3v 264 6 this this DT cord-355239-fc52dn3v 264 7 enzyme enzyme NN cord-355239-fc52dn3v 264 8 , , , cord-355239-fc52dn3v 264 9 they -PRON- PRP cord-355239-fc52dn3v 264 10 prevent prevent VBP cord-355239-fc52dn3v 264 11 new new JJ cord-355239-fc52dn3v 264 12 viral viral JJ cord-355239-fc52dn3v 264 13 particles particle NNS cord-355239-fc52dn3v 264 14 being be VBG cord-355239-fc52dn3v 264 15 released release VBN cord-355239-fc52dn3v 264 16 from from IN cord-355239-fc52dn3v 264 17 infected infected JJ cord-355239-fc52dn3v 264 18 cells cell NNS cord-355239-fc52dn3v 264 19 . . . cord-355239-fc52dn3v 265 1 There there EX cord-355239-fc52dn3v 265 2 are be VBP cord-355239-fc52dn3v 265 3 various various JJ cord-355239-fc52dn3v 265 4 kinds kind NNS cord-355239-fc52dn3v 265 5 of of IN cord-355239-fc52dn3v 265 6 polysaccharides polysaccharide NNS cord-355239-fc52dn3v 265 7 on on IN cord-355239-fc52dn3v 265 8 the the DT cord-355239-fc52dn3v 265 9 surface surface NN cord-355239-fc52dn3v 265 10 of of IN cord-355239-fc52dn3v 265 11 bacteria bacteria NNS cord-355239-fc52dn3v 265 12 . . . cord-355239-fc52dn3v 266 1 Lipoteichoic Lipoteichoic NNP cord-355239-fc52dn3v 266 2 acid acid NN cord-355239-fc52dn3v 266 3 ( ( -LRB- cord-355239-fc52dn3v 266 4 LTA LTA NNP cord-355239-fc52dn3v 266 5 ) ) -RRB- cord-355239-fc52dn3v 266 6 , , , cord-355239-fc52dn3v 266 7 a a DT cord-355239-fc52dn3v 266 8 type type NN cord-355239-fc52dn3v 266 9 of of IN cord-355239-fc52dn3v 266 10 glycolipid glycolipid NN cord-355239-fc52dn3v 266 11 , , , cord-355239-fc52dn3v 266 12 is be VBZ cord-355239-fc52dn3v 266 13 a a DT cord-355239-fc52dn3v 266 14 component component NN cord-355239-fc52dn3v 266 15 of of IN cord-355239-fc52dn3v 266 16 the the DT cord-355239-fc52dn3v 266 17 bacterial bacterial JJ cord-355239-fc52dn3v 266 18 cell cell NN cord-355239-fc52dn3v 266 19 wall wall NN cord-355239-fc52dn3v 266 20 of of IN cord-355239-fc52dn3v 266 21 grampositive grampositive JJ cord-355239-fc52dn3v 266 22 bacteria bacteria NNS cord-355239-fc52dn3v 266 23 . . . cord-355239-fc52dn3v 267 1 Studies study NNS cord-355239-fc52dn3v 267 2 have have VBP cord-355239-fc52dn3v 267 3 shown show VBN cord-355239-fc52dn3v 267 4 that that IN cord-355239-fc52dn3v 267 5 LTA LTA NNP cord-355239-fc52dn3v 267 6 stimulates stimulate VBZ cord-355239-fc52dn3v 267 7 the the DT cord-355239-fc52dn3v 267 8 immune immune JJ cord-355239-fc52dn3v 267 9 system system NN cord-355239-fc52dn3v 267 10 [ [ -LRB- cord-355239-fc52dn3v 267 11 83 83 CD cord-355239-fc52dn3v 267 12 , , , cord-355239-fc52dn3v 267 13 84 84 CD cord-355239-fc52dn3v 267 14 ] ] -RRB- cord-355239-fc52dn3v 267 15 . . . cord-355239-fc52dn3v 268 1 Recently recently RB cord-355239-fc52dn3v 268 2 , , , cord-355239-fc52dn3v 268 3 LTA LTA NNP cord-355239-fc52dn3v 268 4 has have VBZ cord-355239-fc52dn3v 268 5 been be VBN cord-355239-fc52dn3v 268 6 studied study VBN cord-355239-fc52dn3v 268 7 for for IN cord-355239-fc52dn3v 268 8 use use NN cord-355239-fc52dn3v 268 9 as as IN cord-355239-fc52dn3v 268 10 a a DT cord-355239-fc52dn3v 268 11 novel novel JJ cord-355239-fc52dn3v 268 12 kind kind NN cord-355239-fc52dn3v 268 13 of of RB cord-355239-fc52dn3v 268 14 biologically biologically RB cord-355239-fc52dn3v 268 15 active active JJ cord-355239-fc52dn3v 268 16 substance substance NN cord-355239-fc52dn3v 268 17 . . . cord-355239-fc52dn3v 269 1 Recently recently RB cord-355239-fc52dn3v 269 2 , , , cord-355239-fc52dn3v 269 3 sulfated sulfated JJ cord-355239-fc52dn3v 269 4 polysaccharides polysaccharide NNS cord-355239-fc52dn3v 269 5 have have VBP cord-355239-fc52dn3v 269 6 been be VBN cord-355239-fc52dn3v 269 7 analyzed analyze VBN cord-355239-fc52dn3v 269 8 as as IN cord-355239-fc52dn3v 269 9 drug drug NN cord-355239-fc52dn3v 269 10 candidates candidate NNS cord-355239-fc52dn3v 269 11 for for IN cord-355239-fc52dn3v 269 12 protozoan protozoan NN cord-355239-fc52dn3v 269 13 infectious infectious JJ cord-355239-fc52dn3v 269 14 diseases disease NNS cord-355239-fc52dn3v 269 15 [ [ -LRB- cord-355239-fc52dn3v 269 16 3 3 CD cord-355239-fc52dn3v 269 17 , , , cord-355239-fc52dn3v 269 18 85 85 CD cord-355239-fc52dn3v 269 19 , , , cord-355239-fc52dn3v 269 20 86 86 CD cord-355239-fc52dn3v 269 21 ] ] -RRB- cord-355239-fc52dn3v 269 22 . . . cord-355239-fc52dn3v 270 1 According accord VBG cord-355239-fc52dn3v 270 2 to to IN cord-355239-fc52dn3v 270 3 our -PRON- PRP$ cord-355239-fc52dn3v 270 4 data datum NNS cord-355239-fc52dn3v 270 5 , , , cord-355239-fc52dn3v 270 6 the the DT cord-355239-fc52dn3v 270 7 sulfated sulfated JJ cord-355239-fc52dn3v 270 8 positions position NNS cord-355239-fc52dn3v 270 9 in in IN cord-355239-fc52dn3v 270 10 the the DT cord-355239-fc52dn3v 270 11 carbohydrates carbohydrate NNS cord-355239-fc52dn3v 270 12 can can MD cord-355239-fc52dn3v 270 13 be be VB cord-355239-fc52dn3v 270 14 critical critical JJ cord-355239-fc52dn3v 270 15 for for IN cord-355239-fc52dn3v 270 16 the the DT cord-355239-fc52dn3v 270 17 inhibitory inhibitory JJ cord-355239-fc52dn3v 270 18 quality quality NN cord-355239-fc52dn3v 270 19 [ [ -LRB- cord-355239-fc52dn3v 270 20 3 3 CD cord-355239-fc52dn3v 270 21 ] ] -RRB- cord-355239-fc52dn3v 270 22 . . . cord-355239-fc52dn3v 271 1 Collectively collectively RB cord-355239-fc52dn3v 271 2 , , , cord-355239-fc52dn3v 271 3 these these DT cord-355239-fc52dn3v 271 4 studies study NNS cord-355239-fc52dn3v 271 5 highlight highlight VBP cord-355239-fc52dn3v 271 6 the the DT cord-355239-fc52dn3v 271 7 possibility possibility NN cord-355239-fc52dn3v 271 8 that that IN cord-355239-fc52dn3v 271 9 carbohydrate carbohydrate NN cord-355239-fc52dn3v 271 10 drugs drug NNS cord-355239-fc52dn3v 271 11 may may MD cord-355239-fc52dn3v 271 12 be be VB cord-355239-fc52dn3v 271 13 developed develop VBN cord-355239-fc52dn3v 271 14 for for IN cord-355239-fc52dn3v 271 15 the the DT cord-355239-fc52dn3v 271 16 prophylaxis prophylaxis NN cord-355239-fc52dn3v 271 17 and and CC cord-355239-fc52dn3v 271 18 treatment treatment NN cord-355239-fc52dn3v 271 19 of of IN cord-355239-fc52dn3v 271 20 parasitic parasitic JJ cord-355239-fc52dn3v 271 21 infectious infectious JJ cord-355239-fc52dn3v 271 22 diseases disease NNS cord-355239-fc52dn3v 271 23 . . . cord-355239-fc52dn3v 272 1 The the DT cord-355239-fc52dn3v 272 2 results result NNS cord-355239-fc52dn3v 272 3 of of IN cord-355239-fc52dn3v 272 4 our -PRON- PRP$ cord-355239-fc52dn3v 272 5 studies study NNS cord-355239-fc52dn3v 272 6 highlight highlight VBP cord-355239-fc52dn3v 272 7 the the DT cord-355239-fc52dn3v 272 8 possibilities possibility NNS cord-355239-fc52dn3v 272 9 for for IN cord-355239-fc52dn3v 272 10 countermeasures countermeasure NNS cord-355239-fc52dn3v 272 11 against against IN cord-355239-fc52dn3v 272 12 malaria malaria NN cord-355239-fc52dn3v 272 13 and and CC cord-355239-fc52dn3v 272 14 toxoplasmosis toxoplasmosis NN cord-355239-fc52dn3v 272 15 [ [ -LRB- cord-355239-fc52dn3v 272 16 3 3 CD cord-355239-fc52dn3v 272 17 , , , cord-355239-fc52dn3v 272 18 85 85 CD cord-355239-fc52dn3v 272 19 ] ] -RRB- cord-355239-fc52dn3v 272 20 . . . cord-355239-fc52dn3v 273 1 Heparan Heparan NNP cord-355239-fc52dn3v 273 2 sulfate sulfate NN cord-355239-fc52dn3v 273 3 glycosaminoglycans glycosaminoglycan NNS cord-355239-fc52dn3v 273 4 as as IN cord-355239-fc52dn3v 273 5 primary primary JJ cord-355239-fc52dn3v 273 6 cell cell NN cord-355239-fc52dn3v 273 7 surface surface NN cord-355239-fc52dn3v 273 8 receptors receptor NNS cord-355239-fc52dn3v 273 9 for for IN cord-355239-fc52dn3v 273 10 herpes herpes NN cord-355239-fc52dn3v 273 11 simplex simplex NNP cord-355239-fc52dn3v 273 12 virus virus NN cord-355239-fc52dn3v 273 13 Salmonella Salmonella NNP cord-355239-fc52dn3v 273 14 enterica enterica NNP cord-355239-fc52dn3v 274 1 serovar serovar NNP cord-355239-fc52dn3v 274 2 Typhimurium Typhimurium NNP cord-355239-fc52dn3v 274 3 requires require VBZ cord-355239-fc52dn3v 274 4 the the DT cord-355239-fc52dn3v 274 5 Lpf Lpf NNP cord-355239-fc52dn3v 274 6 , , , cord-355239-fc52dn3v 274 7 Pef Pef NNP cord-355239-fc52dn3v 274 8 , , , cord-355239-fc52dn3v 274 9 and and CC cord-355239-fc52dn3v 274 10 Tafi Tafi NNP cord-355239-fc52dn3v 274 11 fimbriae fimbriae NN cord-355239-fc52dn3v 274 12 for for IN cord-355239-fc52dn3v 274 13 biofilm biofilm NN cord-355239-fc52dn3v 274 14 formation formation NN cord-355239-fc52dn3v 274 15 on on IN cord-355239-fc52dn3v 274 16 HEp-2 hep-2 NN cord-355239-fc52dn3v 274 17 tissue tissue NN cord-355239-fc52dn3v 274 18 culture culture NN cord-355239-fc52dn3v 274 19 cells cell NNS cord-355239-fc52dn3v 274 20 and and CC cord-355239-fc52dn3v 274 21 chicken chicken NN cord-355239-fc52dn3v 274 22 intestinal intestinal JJ cord-355239-fc52dn3v 274 23 epithelium epithelium NN cord-355239-fc52dn3v 274 24 Analyses analysis NNS cord-355239-fc52dn3v 274 25 of of IN cord-355239-fc52dn3v 274 26 interactions interaction NNS cord-355239-fc52dn3v 274 27 between between IN cord-355239-fc52dn3v 274 28 heparin heparin NN cord-355239-fc52dn3v 274 29 and and CC cord-355239-fc52dn3v 274 30 the the DT cord-355239-fc52dn3v 274 31 apical apical JJ cord-355239-fc52dn3v 274 32 surface surface NN cord-355239-fc52dn3v 274 33 proteins protein NNS cord-355239-fc52dn3v 274 34 of of IN cord-355239-fc52dn3v 274 35 Plasmodium Plasmodium NNP cord-355239-fc52dn3v 274 36 falciparum falciparum NN cord-355239-fc52dn3v 274 37 Norovirus Norovirus NNP cord-355239-fc52dn3v 274 38 disease disease NN cord-355239-fc52dn3v 274 39 : : : cord-355239-fc52dn3v 274 40 changing change VBG cord-355239-fc52dn3v 274 41 epidemiology epidemiology NN cord-355239-fc52dn3v 274 42 and and CC cord-355239-fc52dn3v 274 43 host host NN cord-355239-fc52dn3v 274 44 susceptibility susceptibility NN cord-355239-fc52dn3v 274 45 factors factor NNS cord-355239-fc52dn3v 274 46 Human human JJ cord-355239-fc52dn3v 274 47 susceptibility susceptibility NN cord-355239-fc52dn3v 274 48 and and CC cord-355239-fc52dn3v 274 49 resistance resistance NN cord-355239-fc52dn3v 274 50 to to IN cord-355239-fc52dn3v 274 51 Norwalk Norwalk NNP cord-355239-fc52dn3v 274 52 virus virus NN cord-355239-fc52dn3v 274 53 infection infection NN cord-355239-fc52dn3v 275 1 Noroviruses noroviruse NNS cord-355239-fc52dn3v 275 2 distinguish distinguish VBP cord-355239-fc52dn3v 275 3 between between IN cord-355239-fc52dn3v 275 4 type type NN cord-355239-fc52dn3v 275 5 1 1 CD cord-355239-fc52dn3v 275 6 and and CC cord-355239-fc52dn3v 275 7 type type NN cord-355239-fc52dn3v 275 8 2 2 CD cord-355239-fc52dn3v 275 9 histo histo JJ cord-355239-fc52dn3v 275 10 - - HYPH cord-355239-fc52dn3v 275 11 blood blood NN cord-355239-fc52dn3v 275 12 group group NN cord-355239-fc52dn3v 275 13 antigens antigen NNS cord-355239-fc52dn3v 275 14 for for IN cord-355239-fc52dn3v 275 15 binding bind VBG cord-355239-fc52dn3v 275 16 Norovirus Norovirus NNP cord-355239-fc52dn3v 275 17 and and CC cord-355239-fc52dn3v 275 18 histoblood histoblood NNP cord-355239-fc52dn3v 275 19 group group NN cord-355239-fc52dn3v 275 20 antigens antigen NNS cord-355239-fc52dn3v 275 21 : : : cord-355239-fc52dn3v 275 22 demonstration demonstration NN cord-355239-fc52dn3v 275 23 of of IN cord-355239-fc52dn3v 275 24 a a DT cord-355239-fc52dn3v 275 25 wide wide JJ cord-355239-fc52dn3v 275 26 spectrum spectrum NN cord-355239-fc52dn3v 275 27 of of IN cord-355239-fc52dn3v 275 28 strain strain NN cord-355239-fc52dn3v 275 29 specificities specificity NNS cord-355239-fc52dn3v 275 30 and and CC cord-355239-fc52dn3v 275 31 classification classification NN cord-355239-fc52dn3v 275 32 of of IN cord-355239-fc52dn3v 275 33 two two CD cord-355239-fc52dn3v 275 34 major major JJ cord-355239-fc52dn3v 275 35 binding bind VBG cord-355239-fc52dn3v 275 36 groups group NNS cord-355239-fc52dn3v 275 37 among among IN cord-355239-fc52dn3v 275 38 multiple multiple JJ cord-355239-fc52dn3v 275 39 binding bind VBG cord-355239-fc52dn3v 275 40 patterns pattern NNS cord-355239-fc52dn3v 275 41 Junctional Junctional NNP cord-355239-fc52dn3v 275 42 adhesion adhesion NN cord-355239-fc52dn3v 275 43 molecule molecule NN cord-355239-fc52dn3v 275 44 1 1 CD cord-355239-fc52dn3v 275 45 is be VBZ cord-355239-fc52dn3v 275 46 a a DT cord-355239-fc52dn3v 275 47 functional functional JJ cord-355239-fc52dn3v 275 48 receptor receptor NN cord-355239-fc52dn3v 275 49 for for IN cord-355239-fc52dn3v 275 50 feline feline JJ cord-355239-fc52dn3v 275 51 calicivirus calicivirus NNP cord-355239-fc52dn3v 275 52 Alpha2,6-linked Alpha2,6-linked NNP cord-355239-fc52dn3v 275 53 sialic sialic JJ cord-355239-fc52dn3v 275 54 acid acid NN cord-355239-fc52dn3v 275 55 acts act VBZ cord-355239-fc52dn3v 275 56 as as IN cord-355239-fc52dn3v 275 57 a a DT cord-355239-fc52dn3v 275 58 receptor receptor NN cord-355239-fc52dn3v 275 59 for for IN cord-355239-fc52dn3v 275 60 Feline feline JJ cord-355239-fc52dn3v 275 61 calicivirus calicivirus NNP cord-355239-fc52dn3v 276 1 The the DT cord-355239-fc52dn3v 276 2 role role NN cord-355239-fc52dn3v 276 3 of of IN cord-355239-fc52dn3v 276 4 M M NNP cord-355239-fc52dn3v 276 5 cells cell NNS cord-355239-fc52dn3v 276 6 in in IN cord-355239-fc52dn3v 276 7 Salmonella Salmonella NNP cord-355239-fc52dn3v 276 8 infection infection NN cord-355239-fc52dn3v 276 9 Sialic Sialic NNP cord-355239-fc52dn3v 276 10 acid acid NN cord-355239-fc52dn3v 276 11 is be VBZ cord-355239-fc52dn3v 276 12 required require VBN cord-355239-fc52dn3v 276 13 for for IN cord-355239-fc52dn3v 276 14 nonspecific nonspecific JJ cord-355239-fc52dn3v 276 15 adherence adherence NN cord-355239-fc52dn3v 276 16 of of IN cord-355239-fc52dn3v 276 17 Salmonella Salmonella NNP cord-355239-fc52dn3v 276 18 enterica enterica NNP cord-355239-fc52dn3v 276 19 ssp ssp NNP cord-355239-fc52dn3v 276 20 . . . cord-355239-fc52dn3v 277 1 enterica enterica NNP cord-355239-fc52dn3v 277 2 serovar serovar NNP cord-355239-fc52dn3v 277 3 Typhi Typhi NNP cord-355239-fc52dn3v 277 4 on on IN cord-355239-fc52dn3v 277 5 Caco-2 Caco-2 NNP cord-355239-fc52dn3v 277 6 cells cell NNS cord-355239-fc52dn3v 277 7 Contribution Contribution NNP cord-355239-fc52dn3v 277 8 of of IN cord-355239-fc52dn3v 277 9 fimbrial fimbrial JJ cord-355239-fc52dn3v 277 10 operons operon NNS cord-355239-fc52dn3v 277 11 to to TO cord-355239-fc52dn3v 277 12 attachment attachment VB cord-355239-fc52dn3v 277 13 to to IN cord-355239-fc52dn3v 277 14 and and CC cord-355239-fc52dn3v 277 15 invasion invasion NN cord-355239-fc52dn3v 277 16 of of IN cord-355239-fc52dn3v 277 17 epithelial epithelial JJ cord-355239-fc52dn3v 277 18 cell cell NN cord-355239-fc52dn3v 277 19 lines line NNS cord-355239-fc52dn3v 277 20 by by IN cord-355239-fc52dn3v 277 21 Salmonella Salmonella NNP cord-355239-fc52dn3v 277 22 typhimurium typhimurium NN cord-355239-fc52dn3v 277 23 Binding bind VBG cord-355239-fc52dn3v 277 24 specificity specificity NN cord-355239-fc52dn3v 277 25 of of IN cord-355239-fc52dn3v 277 26 Salmonella Salmonella NNP cord-355239-fc52dn3v 277 27 plasmid plasmid NN cord-355239-fc52dn3v 277 28 - - HYPH cord-355239-fc52dn3v 277 29 encoded encode VBN cord-355239-fc52dn3v 277 30 fimbriae fimbriae NN cord-355239-fc52dn3v 277 31 assessed assess VBN cord-355239-fc52dn3v 277 32 by by IN cord-355239-fc52dn3v 277 33 glycomics glycomics NNP cord-355239-fc52dn3v 277 34 Salmonella Salmonella NNP cord-355239-fc52dn3v 277 35 enterica enterica NN cord-355239-fc52dn3v 277 36 serotype serotype NN cord-355239-fc52dn3v 277 37 Typhimurium Typhimurium NNP cord-355239-fc52dn3v 277 38 Std Std NNP cord-355239-fc52dn3v 277 39 fimbriae fimbriae NN cord-355239-fc52dn3v 277 40 bind bind NN cord-355239-fc52dn3v 277 41 terminal terminal NN cord-355239-fc52dn3v 278 1 alpha(1,2)fucose alpha(1,2)fucose NN cord-355239-fc52dn3v 278 2 residues residue NNS cord-355239-fc52dn3v 278 3 in in IN cord-355239-fc52dn3v 278 4 the the DT cord-355239-fc52dn3v 278 5 cecal cecal JJ cord-355239-fc52dn3v 278 6 mucosa mucosa NN cord-355239-fc52dn3v 278 7 Salmonella Salmonella NNP cord-355239-fc52dn3v 278 8 enterica enterica NNP cord-355239-fc52dn3v 279 1 serovar serovar NNP cord-355239-fc52dn3v 279 2 typhi typhi NNP cord-355239-fc52dn3v 279 3 uses use VBZ cord-355239-fc52dn3v 279 4 type type NN cord-355239-fc52dn3v 279 5 IVB IVB NNP cord-355239-fc52dn3v 279 6 pili pili NNP cord-355239-fc52dn3v 279 7 to to TO cord-355239-fc52dn3v 279 8 enter enter VB cord-355239-fc52dn3v 279 9 human human JJ cord-355239-fc52dn3v 279 10 intestinal intestinal JJ cord-355239-fc52dn3v 279 11 epithelial epithelial JJ cord-355239-fc52dn3v 279 12 cells cell NNS cord-355239-fc52dn3v 280 1 Multiple multiple JJ cord-355239-fc52dn3v 280 2 fimbrial fimbrial JJ cord-355239-fc52dn3v 280 3 adhesins adhesin NNS cord-355239-fc52dn3v 280 4 are be VBP cord-355239-fc52dn3v 280 5 required require VBN cord-355239-fc52dn3v 280 6 for for IN cord-355239-fc52dn3v 280 7 full full JJ cord-355239-fc52dn3v 280 8 virulence virulence NN cord-355239-fc52dn3v 280 9 of of IN cord-355239-fc52dn3v 280 10 Salmonella Salmonella NNP cord-355239-fc52dn3v 280 11 typhimurium typhimurium NN cord-355239-fc52dn3v 280 12 in in IN cord-355239-fc52dn3v 280 13 mice mouse NNS cord-355239-fc52dn3v 281 1 Salmonella Salmonella NNP cord-355239-fc52dn3v 281 2 enterica enterica NNP cord-355239-fc52dn3v 282 1 serovar serovar NNP cord-355239-fc52dn3v 282 2 Typhimurium Typhimurium NNP cord-355239-fc52dn3v 282 3 binds bind VBZ cord-355239-fc52dn3v 282 4 to to IN cord-355239-fc52dn3v 282 5 HeLa HeLa NNP cord-355239-fc52dn3v 282 6 cells cell NNS cord-355239-fc52dn3v 282 7 via via IN cord-355239-fc52dn3v 282 8 Fim Fim NNP cord-355239-fc52dn3v 282 9 - - HYPH cord-355239-fc52dn3v 282 10 mediated mediate VBN cord-355239-fc52dn3v 282 11 reversible reversible JJ cord-355239-fc52dn3v 282 12 adhesion adhesion NN cord-355239-fc52dn3v 282 13 and and CC cord-355239-fc52dn3v 282 14 irreversible irreversible JJ cord-355239-fc52dn3v 282 15 type type NN cord-355239-fc52dn3v 282 16 three three CD cord-355239-fc52dn3v 282 17 secretion secretion NN cord-355239-fc52dn3v 282 18 system system NN cord-355239-fc52dn3v 282 19 1-mediated 1-mediated CD cord-355239-fc52dn3v 282 20 docking dock VBG cord-355239-fc52dn3v 282 21 Direct direct JJ cord-355239-fc52dn3v 282 22 evidence evidence NN cord-355239-fc52dn3v 282 23 that that IN cord-355239-fc52dn3v 282 24 the the DT cord-355239-fc52dn3v 282 25 FimH FimH NNP cord-355239-fc52dn3v 282 26 protein protein NN cord-355239-fc52dn3v 282 27 is be VBZ cord-355239-fc52dn3v 282 28 the the DT cord-355239-fc52dn3v 282 29 mannose mannose NN cord-355239-fc52dn3v 282 30 - - HYPH cord-355239-fc52dn3v 282 31 specific specific JJ cord-355239-fc52dn3v 282 32 adhesin adhesin NN cord-355239-fc52dn3v 282 33 of of IN cord-355239-fc52dn3v 282 34 Escherichia Escherichia NNP cord-355239-fc52dn3v 282 35 coli coli VBZ cord-355239-fc52dn3v 282 36 type type NN cord-355239-fc52dn3v 282 37 1 1 CD cord-355239-fc52dn3v 282 38 fimbriae fimbriae NN cord-355239-fc52dn3v 282 39 Carbohydrates carbohydrate NNS cord-355239-fc52dn3v 282 40 as as IN cord-355239-fc52dn3v 282 41 future future JJ cord-355239-fc52dn3v 282 42 anti anti JJ cord-355239-fc52dn3v 282 43 - - JJ cord-355239-fc52dn3v 282 44 adhesion adhesion JJ cord-355239-fc52dn3v 282 45 drugs drug NNS cord-355239-fc52dn3v 282 46 for for IN cord-355239-fc52dn3v 282 47 infectious infectious JJ cord-355239-fc52dn3v 282 48 diseases disease NNS cord-355239-fc52dn3v 282 49 Role role NN cord-355239-fc52dn3v 282 50 of of IN cord-355239-fc52dn3v 282 51 intimin intimin NN cord-355239-fc52dn3v 282 52 and and CC cord-355239-fc52dn3v 282 53 bundle bundle NN cord-355239-fc52dn3v 282 54 - - HYPH cord-355239-fc52dn3v 282 55 forming form VBG cord-355239-fc52dn3v 282 56 pili pili NNP cord-355239-fc52dn3v 282 57 in in IN cord-355239-fc52dn3v 282 58 enteropathogenic enteropathogenic JJ cord-355239-fc52dn3v 282 59 Escherichia Escherichia NNP cord-355239-fc52dn3v 282 60 coli coli VBZ cord-355239-fc52dn3v 282 61 adhesion adhesion NN cord-355239-fc52dn3v 282 62 to to IN cord-355239-fc52dn3v 282 63 pediatric pediatric JJ cord-355239-fc52dn3v 282 64 intestinal intestinal JJ cord-355239-fc52dn3v 282 65 tissue tissue NN cord-355239-fc52dn3v 282 66 in in IN cord-355239-fc52dn3v 282 67 vitro vitro FW cord-355239-fc52dn3v 283 1 The the DT cord-355239-fc52dn3v 283 2 lpf lpf NNP cord-355239-fc52dn3v 283 3 fimbrial fimbrial JJ cord-355239-fc52dn3v 283 4 operon operon NN cord-355239-fc52dn3v 283 5 mediates mediate VBZ cord-355239-fc52dn3v 283 6 adhesion adhesion NN cord-355239-fc52dn3v 283 7 of of IN cord-355239-fc52dn3v 283 8 Salmonella Salmonella NNP cord-355239-fc52dn3v 283 9 typhimurium typhimurium NN cord-355239-fc52dn3v 283 10 to to IN cord-355239-fc52dn3v 283 11 murine murine JJ cord-355239-fc52dn3v 283 12 Peyer Peyer NNP cord-355239-fc52dn3v 283 13 's 's POS cord-355239-fc52dn3v 283 14 patches patch NNS cord-355239-fc52dn3v 283 15 Initial initial JJ cord-355239-fc52dn3v 283 16 adherence adherence NN cord-355239-fc52dn3v 283 17 of of IN cord-355239-fc52dn3v 283 18 EPEC EPEC NNP cord-355239-fc52dn3v 283 19 , , , cord-355239-fc52dn3v 283 20 EHEC EHEC NNP cord-355239-fc52dn3v 283 21 and and CC cord-355239-fc52dn3v 283 22 VTEC VTEC NNP cord-355239-fc52dn3v 283 23 to to TO cord-355239-fc52dn3v 283 24 host host NN cord-355239-fc52dn3v 283 25 cells cell NNS cord-355239-fc52dn3v 284 1 Long long JJ cord-355239-fc52dn3v 284 2 polar polar JJ cord-355239-fc52dn3v 284 3 fimbriae fimbriae NN cord-355239-fc52dn3v 284 4 of of IN cord-355239-fc52dn3v 284 5 enterohemorrhagic enterohemorrhagic NNP cord-355239-fc52dn3v 285 1 Escherichia Escherichia NNP cord-355239-fc52dn3v 285 2 coli coli NNS cord-355239-fc52dn3v 285 3 O157 O157 NNP cord-355239-fc52dn3v 285 4 : : : cord-355239-fc52dn3v 286 1 H7 H7 NNP cord-355239-fc52dn3v 286 2 bind bind VBP cord-355239-fc52dn3v 286 3 to to IN cord-355239-fc52dn3v 286 4 extracellular extracellular JJ cord-355239-fc52dn3v 286 5 matrix matrix NN cord-355239-fc52dn3v 286 6 proteins protein NNS cord-355239-fc52dn3v 286 7 Pathogenomics pathogenomic NNS cord-355239-fc52dn3v 286 8 of of IN cord-355239-fc52dn3v 286 9 the the DT cord-355239-fc52dn3v 286 10 virulence virulence NN cord-355239-fc52dn3v 286 11 plasmids plasmid NNS cord-355239-fc52dn3v 286 12 of of IN cord-355239-fc52dn3v 286 13 Escherichia Escherichia NNP cord-355239-fc52dn3v 286 14 coli coli VBZ cord-355239-fc52dn3v 286 15 Thin thin JJ cord-355239-fc52dn3v 286 16 pilus pilus NN cord-355239-fc52dn3v 286 17 PilV PilV NNP cord-355239-fc52dn3v 286 18 adhesins adhesin NNS cord-355239-fc52dn3v 286 19 of of IN cord-355239-fc52dn3v 286 20 plasmid plasmid NN cord-355239-fc52dn3v 287 1 R64 r64 JJ cord-355239-fc52dn3v 287 2 recognize recognize VBP cord-355239-fc52dn3v 287 3 specific specific JJ cord-355239-fc52dn3v 287 4 structures structure NNS cord-355239-fc52dn3v 287 5 of of IN cord-355239-fc52dn3v 287 6 the the DT cord-355239-fc52dn3v 287 7 lipopolysaccharide lipopolysaccharide NN cord-355239-fc52dn3v 287 8 molecules molecule NNS cord-355239-fc52dn3v 287 9 of of IN cord-355239-fc52dn3v 287 10 recipient recipient NN cord-355239-fc52dn3v 287 11 cells cell NNS cord-355239-fc52dn3v 288 1 PilV PilV NNP cord-355239-fc52dn3v 288 2 adhesins adhesin NNS cord-355239-fc52dn3v 288 3 of of IN cord-355239-fc52dn3v 288 4 plasmid plasmid NN cord-355239-fc52dn3v 288 5 R64 R64 NNP cord-355239-fc52dn3v 288 6 thin thin JJ cord-355239-fc52dn3v 288 7 pili pili NNP cord-355239-fc52dn3v 288 8 specifically specifically RB cord-355239-fc52dn3v 288 9 bind bind VB cord-355239-fc52dn3v 288 10 to to IN cord-355239-fc52dn3v 288 11 the the DT cord-355239-fc52dn3v 288 12 lipopolysaccharides lipopolysaccharide NNS cord-355239-fc52dn3v 288 13 of of IN cord-355239-fc52dn3v 288 14 recipient recipient NN cord-355239-fc52dn3v 288 15 cells cell NNS cord-355239-fc52dn3v 288 16 FimH FimH NNP cord-355239-fc52dn3v 288 17 alleles allele NNS cord-355239-fc52dn3v 288 18 direct direct JJ cord-355239-fc52dn3v 288 19 preferential preferential JJ cord-355239-fc52dn3v 288 20 binding binding NN cord-355239-fc52dn3v 288 21 of of IN cord-355239-fc52dn3v 288 22 Salmonella Salmonella NNP cord-355239-fc52dn3v 288 23 to to IN cord-355239-fc52dn3v 288 24 distinct distinct JJ cord-355239-fc52dn3v 288 25 mammalian mammalian JJ cord-355239-fc52dn3v 288 26 cells cell NNS cord-355239-fc52dn3v 288 27 or or CC cord-355239-fc52dn3v 288 28 to to IN cord-355239-fc52dn3v 288 29 avian avian JJ cord-355239-fc52dn3v 288 30 cells cell NNS cord-355239-fc52dn3v 288 31 Role role NN cord-355239-fc52dn3v 288 32 of of IN cord-355239-fc52dn3v 288 33 Lewis Lewis NNP cord-355239-fc52dn3v 288 34 A A NNP cord-355239-fc52dn3v 288 35 and and CC cord-355239-fc52dn3v 289 1 Lewis Lewis NNP cord-355239-fc52dn3v 289 2 B B NNP cord-355239-fc52dn3v 289 3 blood blood NN cord-355239-fc52dn3v 289 4 group group NN cord-355239-fc52dn3v 289 5 antigens antigen NNS cord-355239-fc52dn3v 289 6 in in IN cord-355239-fc52dn3v 289 7 Helicobacter Helicobacter NNP cord-355239-fc52dn3v 289 8 pylori pylori NN cord-355239-fc52dn3v 289 9 infection infection NN cord-355239-fc52dn3v 289 10 Chemical chemical JJ cord-355239-fc52dn3v 289 11 structures structure NNS cord-355239-fc52dn3v 289 12 of of IN cord-355239-fc52dn3v 289 13 the the DT cord-355239-fc52dn3v 289 14 core core NN cord-355239-fc52dn3v 289 15 regions region NNS cord-355239-fc52dn3v 289 16 of of IN cord-355239-fc52dn3v 289 17 Campylobacter Campylobacter NNP cord-355239-fc52dn3v 289 18 jejuni jejuni NNP cord-355239-fc52dn3v 289 19 serotypes serotypes NN cord-355239-fc52dn3v 289 20 O:1 O:1 NNP cord-355239-fc52dn3v 289 21 , , , cord-355239-fc52dn3v 289 22 O:4 O:4 NNP cord-355239-fc52dn3v 289 23 , , , cord-355239-fc52dn3v 289 24 O:23 O:23 NNP cord-355239-fc52dn3v 289 25 , , , cord-355239-fc52dn3v 289 26 and and CC cord-355239-fc52dn3v 289 27 O:36 O:36 NNP cord-355239-fc52dn3v 289 28 lipopolysaccharides lipopolysaccharides NNP cord-355239-fc52dn3v 290 1 Expression expression NN cord-355239-fc52dn3v 290 2 of of IN cord-355239-fc52dn3v 290 3 the the DT cord-355239-fc52dn3v 290 4 human human JJ cord-355239-fc52dn3v 290 5 cell cell NN cord-355239-fc52dn3v 290 6 surface surface NN cord-355239-fc52dn3v 290 7 glycoconjugates glycoconjugate NNS cord-355239-fc52dn3v 291 1 Lewis Lewis NNP cord-355239-fc52dn3v 291 2 x x NNP cord-355239-fc52dn3v 291 3 and and CC cord-355239-fc52dn3v 291 4 Lewis Lewis NNP cord-355239-fc52dn3v 291 5 y y NNP cord-355239-fc52dn3v 291 6 by by IN cord-355239-fc52dn3v 291 7 Helicobacter Helicobacter NNP cord-355239-fc52dn3v 291 8 pylori pylori NN cord-355239-fc52dn3v 291 9 isolates isolate NNS cord-355239-fc52dn3v 291 10 is be VBZ cord-355239-fc52dn3v 291 11 related relate VBN cord-355239-fc52dn3v 291 12 to to IN cord-355239-fc52dn3v 291 13 cagA caga CD cord-355239-fc52dn3v 291 14 status status NN cord-355239-fc52dn3v 291 15 Gangliosides Gangliosides NNP cord-355239-fc52dn3v 291 16 act act VBP cord-355239-fc52dn3v 291 17 as as IN cord-355239-fc52dn3v 291 18 co co NNS cord-355239-fc52dn3v 291 19 - - NNS cord-355239-fc52dn3v 291 20 receptors receptor NNS cord-355239-fc52dn3v 291 21 for for IN cord-355239-fc52dn3v 291 22 Salmonella Salmonella NNP cord-355239-fc52dn3v 291 23 enteritidis enteritidis NN cord-355239-fc52dn3v 291 24 FliC flic NN cord-355239-fc52dn3v 291 25 and and CC cord-355239-fc52dn3v 291 26 promote promote VB cord-355239-fc52dn3v 291 27 FliC flic NN cord-355239-fc52dn3v 291 28 induction induction NN cord-355239-fc52dn3v 291 29 of of IN cord-355239-fc52dn3v 291 30 human human JJ cord-355239-fc52dn3v 291 31 beta beta NN cord-355239-fc52dn3v 291 32 - - HYPH cord-355239-fc52dn3v 291 33 defensin-2 defensin-2 NN cord-355239-fc52dn3v 291 34 expression expression NN cord-355239-fc52dn3v 291 35 in in IN cord-355239-fc52dn3v 291 36 Caco-2 Caco-2 NNP cord-355239-fc52dn3v 291 37 cells cell NNS cord-355239-fc52dn3v 292 1 Inactivation inactivation NN cord-355239-fc52dn3v 292 2 of of IN cord-355239-fc52dn3v 292 3 the the DT cord-355239-fc52dn3v 292 4 flagellin flagellin JJ cord-355239-fc52dn3v 292 5 gene gene NN cord-355239-fc52dn3v 292 6 of of IN cord-355239-fc52dn3v 292 7 Salmonella Salmonella NNP cord-355239-fc52dn3v 292 8 enterica enterica NNP cord-355239-fc52dn3v 292 9 serotype serotype NN cord-355239-fc52dn3v 292 10 enteritidis enteritidis NN cord-355239-fc52dn3v 292 11 strongly strongly RB cord-355239-fc52dn3v 292 12 reduces reduce VBZ cord-355239-fc52dn3v 292 13 invasion invasion NN cord-355239-fc52dn3v 292 14 into into IN cord-355239-fc52dn3v 292 15 differentiated differentiated JJ cord-355239-fc52dn3v 292 16 Caco-2 caco-2 NN cord-355239-fc52dn3v 292 17 cells cell NNS cord-355239-fc52dn3v 292 18 Active active JJ cord-355239-fc52dn3v 292 19 invasion invasion NN cord-355239-fc52dn3v 292 20 and/or and/or CC cord-355239-fc52dn3v 292 21 encapsulation encapsulation NN cord-355239-fc52dn3v 292 22 ? ? . cord-355239-fc52dn3v 293 1 A a DT cord-355239-fc52dn3v 293 2 reappraisal reappraisal NN cord-355239-fc52dn3v 293 3 of of IN cord-355239-fc52dn3v 293 4 host host NN cord-355239-fc52dn3v 293 5 - - HYPH cord-355239-fc52dn3v 293 6 cell cell NN cord-355239-fc52dn3v 293 7 parasitism parasitism NN cord-355239-fc52dn3v 293 8 by by IN cord-355239-fc52dn3v 293 9 Cryptosporidium cryptosporidium NN cord-355239-fc52dn3v 293 10 Host host NN cord-355239-fc52dn3v 293 11 cell cell NN cord-355239-fc52dn3v 293 12 surface surface NN cord-355239-fc52dn3v 293 13 sialic sialic NN cord-355239-fc52dn3v 293 14 acid acid NN cord-355239-fc52dn3v 293 15 residues residue NNS cord-355239-fc52dn3v 293 16 are be VBP cord-355239-fc52dn3v 293 17 involved involve VBN cord-355239-fc52dn3v 293 18 on on IN cord-355239-fc52dn3v 293 19 the the DT cord-355239-fc52dn3v 293 20 process process NN cord-355239-fc52dn3v 293 21 of of IN cord-355239-fc52dn3v 293 22 penetration penetration NN cord-355239-fc52dn3v 293 23 of of IN cord-355239-fc52dn3v 293 24 Toxoplasma toxoplasma JJ cord-355239-fc52dn3v 293 25 gondii gondii NN cord-355239-fc52dn3v 293 26 into into IN cord-355239-fc52dn3v 293 27 mammalian mammalian JJ cord-355239-fc52dn3v 293 28 cells cell NNS cord-355239-fc52dn3v 293 29 Synergistic synergistic JJ cord-355239-fc52dn3v 293 30 role role NN cord-355239-fc52dn3v 293 31 of of IN cord-355239-fc52dn3v 293 32 micronemal micronemal JJ cord-355239-fc52dn3v 293 33 proteins protein NNS cord-355239-fc52dn3v 293 34 in in IN cord-355239-fc52dn3v 293 35 Toxoplasma toxoplasma JJ cord-355239-fc52dn3v 293 36 gondii gondii NN cord-355239-fc52dn3v 293 37 virulence virulence NN cord-355239-fc52dn3v 293 38 Atomic atomic JJ cord-355239-fc52dn3v 293 39 resolution resolution NN cord-355239-fc52dn3v 293 40 insight insight NN cord-355239-fc52dn3v 293 41 into into IN cord-355239-fc52dn3v 293 42 host host NN cord-355239-fc52dn3v 293 43 cell cell NN cord-355239-fc52dn3v 293 44 recognition recognition NN cord-355239-fc52dn3v 293 45 by by IN cord-355239-fc52dn3v 293 46 Toxoplasma Toxoplasma NNP cord-355239-fc52dn3v 293 47 gondii gondii NNP cord-355239-fc52dn3v 293 48 Members Members NNPS cord-355239-fc52dn3v 293 49 of of IN cord-355239-fc52dn3v 293 50 a a DT cord-355239-fc52dn3v 293 51 novel novel JJ cord-355239-fc52dn3v 293 52 protein protein NN cord-355239-fc52dn3v 293 53 family family NN cord-355239-fc52dn3v 293 54 containing contain VBG cord-355239-fc52dn3v 293 55 microneme microneme NNP cord-355239-fc52dn3v 293 56 adhesive adhesive NNP cord-355239-fc52dn3v 293 57 repeat repeat NN cord-355239-fc52dn3v 293 58 domains domain NNS cord-355239-fc52dn3v 293 59 act act VBP cord-355239-fc52dn3v 293 60 as as IN cord-355239-fc52dn3v 293 61 sialic sialic JJ cord-355239-fc52dn3v 293 62 acid acid NN cord-355239-fc52dn3v 293 63 - - HYPH cord-355239-fc52dn3v 293 64 binding bind VBG cord-355239-fc52dn3v 293 65 lectins lectin NNS cord-355239-fc52dn3v 293 66 during during IN cord-355239-fc52dn3v 293 67 host host NN cord-355239-fc52dn3v 293 68 cell cell NN cord-355239-fc52dn3v 293 69 invasion invasion NN cord-355239-fc52dn3v 293 70 by by IN cord-355239-fc52dn3v 293 71 apicomplexan apicomplexan NNP cord-355239-fc52dn3v 293 72 parasites parasite NNS cord-355239-fc52dn3v 294 1 A a DT cord-355239-fc52dn3v 294 2 novel novel JJ cord-355239-fc52dn3v 294 3 PAN PAN NNP cord-355239-fc52dn3v 294 4 / / SYM cord-355239-fc52dn3v 294 5 apple apple NN cord-355239-fc52dn3v 294 6 domain domain NN cord-355239-fc52dn3v 294 7 - - HYPH cord-355239-fc52dn3v 294 8 containing contain VBG cord-355239-fc52dn3v 294 9 protein protein NN cord-355239-fc52dn3v 294 10 from from IN cord-355239-fc52dn3v 294 11 Toxoplasma Toxoplasma NNP cord-355239-fc52dn3v 294 12 gondii gondii NN cord-355239-fc52dn3v 294 13 : : : cord-355239-fc52dn3v 294 14 characterization characterization NN cord-355239-fc52dn3v 294 15 and and CC cord-355239-fc52dn3v 294 16 receptor receptor NN cord-355239-fc52dn3v 294 17 identification identification NN cord-355239-fc52dn3v 295 1 The the DT cord-355239-fc52dn3v 295 2 surface surface NN cord-355239-fc52dn3v 295 3 of of IN cord-355239-fc52dn3v 295 4 Toxoplasma toxoplasma NN cord-355239-fc52dn3v 295 5 : : : cord-355239-fc52dn3v 295 6 more more JJR cord-355239-fc52dn3v 295 7 and and CC cord-355239-fc52dn3v 295 8 less less RBR cord-355239-fc52dn3v 295 9 Targeted targeted JJ cord-355239-fc52dn3v 295 10 disruption disruption NN cord-355239-fc52dn3v 295 11 of of IN cord-355239-fc52dn3v 295 12 the the DT cord-355239-fc52dn3v 295 13 glycosylphosphatidylinositolanchored glycosylphosphatidylinositolanchored NNP cord-355239-fc52dn3v 295 14 surface surface NN cord-355239-fc52dn3v 295 15 antigen antigen NN cord-355239-fc52dn3v 295 16 SAG3 SAG3 NNP cord-355239-fc52dn3v 295 17 gene gene NN cord-355239-fc52dn3v 295 18 in in IN cord-355239-fc52dn3v 295 19 Toxoplasma Toxoplasma NNP cord-355239-fc52dn3v 295 20 gondii gondii NNP cord-355239-fc52dn3v 295 21 decreases decrease VBZ cord-355239-fc52dn3v 295 22 host host NN cord-355239-fc52dn3v 295 23 cell cell NN cord-355239-fc52dn3v 295 24 adhesion adhesion NN cord-355239-fc52dn3v 295 25 and and CC cord-355239-fc52dn3v 295 26 drastically drastically RB cord-355239-fc52dn3v 295 27 reduces reduce VBZ cord-355239-fc52dn3v 295 28 virulence virulence NN cord-355239-fc52dn3v 295 29 in in IN cord-355239-fc52dn3v 295 30 mice mouse NNS cord-355239-fc52dn3v 296 1 Toxoplasma Toxoplasma NNP cord-355239-fc52dn3v 296 2 gondii gondii NNP cord-355239-fc52dn3v 296 3 : : : cord-355239-fc52dn3v 296 4 the the DT cord-355239-fc52dn3v 296 5 role role NN cord-355239-fc52dn3v 296 6 of of IN cord-355239-fc52dn3v 296 7 parasite parasite NN cord-355239-fc52dn3v 296 8 surface surface NN cord-355239-fc52dn3v 296 9 and and CC cord-355239-fc52dn3v 296 10 secreted secrete VBN cord-355239-fc52dn3v 296 11 proteins protein NNS cord-355239-fc52dn3v 296 12 in in IN cord-355239-fc52dn3v 296 13 host host NN cord-355239-fc52dn3v 296 14 cell cell NN cord-355239-fc52dn3v 296 15 invasion invasion NN cord-355239-fc52dn3v 297 1 The the DT cord-355239-fc52dn3v 297 2 surface surface NN cord-355239-fc52dn3v 297 3 anti-50 anti-50 XX cord-355239-fc52dn3v 297 4 gen gen NNP cord-355239-fc52dn3v 297 5 SAG3 SAG3 NNP cord-355239-fc52dn3v 297 6 mediates mediate VBZ cord-355239-fc52dn3v 297 7 the the DT cord-355239-fc52dn3v 297 8 attachment attachment NN cord-355239-fc52dn3v 297 9 of of IN cord-355239-fc52dn3v 297 10 Toxoplasma toxoplasma JJ cord-355239-fc52dn3v 297 11 gondii gondii NNS cord-355239-fc52dn3v 297 12 to to IN cord-355239-fc52dn3v 297 13 cell cell NN cord-355239-fc52dn3v 297 14 - - HYPH cord-355239-fc52dn3v 297 15 surface surface NN cord-355239-fc52dn3v 297 16 proteoglycans proteoglycan NNS cord-355239-fc52dn3v 297 17 Physical physical JJ cord-355239-fc52dn3v 297 18 , , , cord-355239-fc52dn3v 297 19 structural structural JJ cord-355239-fc52dn3v 297 20 , , , cord-355239-fc52dn3v 297 21 and and CC cord-355239-fc52dn3v 297 22 functional functional JJ cord-355239-fc52dn3v 297 23 properties property NNS cord-355239-fc52dn3v 297 24 of of IN cord-355239-fc52dn3v 297 25 the the DT cord-355239-fc52dn3v 297 26 beta1 beta1 NN cord-355239-fc52dn3v 297 27 integrin integrin NN cord-355239-fc52dn3v 297 28 - - HYPH cord-355239-fc52dn3v 297 29 like like JJ cord-355239-fc52dn3v 297 30 fibronectin fibronectin NN cord-355239-fc52dn3v 297 31 receptor receptor NN cord-355239-fc52dn3v 297 32 ( ( -LRB- cord-355239-fc52dn3v 297 33 beta1EhFNR beta1EhFNR NNP cord-355239-fc52dn3v 297 34 ) ) -RRB- cord-355239-fc52dn3v 297 35 in in IN cord-355239-fc52dn3v 297 36 Entamoeba Entamoeba NNP cord-355239-fc52dn3v 297 37 histolytica histolytica NNP cord-355239-fc52dn3v 297 38 Entamoeba Entamoeba NNP cord-355239-fc52dn3v 297 39 histolytica histolytica NNP cord-355239-fc52dn3v 297 40 : : : cord-355239-fc52dn3v 297 41 lipid lipid NN cord-355239-fc52dn3v 297 42 rafts raft NNS cord-355239-fc52dn3v 297 43 are be VBP cord-355239-fc52dn3v 297 44 involved involve VBN cord-355239-fc52dn3v 297 45 in in IN cord-355239-fc52dn3v 297 46 adhesion adhesion NN cord-355239-fc52dn3v 297 47 of of IN cord-355239-fc52dn3v 297 48 trophozoites trophozoite NNS cord-355239-fc52dn3v 297 49 to to TO cord-355239-fc52dn3v 297 50 host host VB cord-355239-fc52dn3v 297 51 extracellular extracellular JJ cord-355239-fc52dn3v 297 52 matrix matrix NN cord-355239-fc52dn3v 297 53 components component NNS cord-355239-fc52dn3v 298 1 A a DT cord-355239-fc52dn3v 299 1 novel novel JJ cord-355239-fc52dn3v 299 2 multidomain multidomain NN cord-355239-fc52dn3v 299 3 mucin mucin NN cord-355239-fc52dn3v 299 4 - - HYPH cord-355239-fc52dn3v 299 5 like like JJ cord-355239-fc52dn3v 299 6 glycoprotein glycoprotein NN cord-355239-fc52dn3v 299 7 of of IN cord-355239-fc52dn3v 299 8 Cryptosporidium Cryptosporidium NNP cord-355239-fc52dn3v 299 9 parvum parvum NNP cord-355239-fc52dn3v 299 10 mediates mediate VBZ cord-355239-fc52dn3v 299 11 invasion invasion NN cord-355239-fc52dn3v 299 12 Mediation Mediation NNP cord-355239-fc52dn3v 299 13 of of IN cord-355239-fc52dn3v 299 14 Cryptosporidium Cryptosporidium NNP cord-355239-fc52dn3v 299 15 parvum parvum NN cord-355239-fc52dn3v 299 16 infection infection NN cord-355239-fc52dn3v 299 17 in in IN cord-355239-fc52dn3v 299 18 vitro vitro FW cord-355239-fc52dn3v 299 19 by by IN cord-355239-fc52dn3v 299 20 mucin mucin NN cord-355239-fc52dn3v 299 21 - - HYPH cord-355239-fc52dn3v 299 22 like like JJ cord-355239-fc52dn3v 299 23 glycoproteins glycoprotein NNS cord-355239-fc52dn3v 299 24 defined define VBN cord-355239-fc52dn3v 299 25 by by IN cord-355239-fc52dn3v 299 26 a a DT cord-355239-fc52dn3v 299 27 neutralizing neutralize VBG cord-355239-fc52dn3v 299 28 monoclonal monoclonal JJ cord-355239-fc52dn3v 299 29 antibody antibody NN cord-355239-fc52dn3v 299 30 Cloning cloning NN cord-355239-fc52dn3v 299 31 and and CC cord-355239-fc52dn3v 299 32 sequence sequence NN cord-355239-fc52dn3v 299 33 analysis analysis NN cord-355239-fc52dn3v 299 34 of of IN cord-355239-fc52dn3v 299 35 a a DT cord-355239-fc52dn3v 299 36 highly highly RB cord-355239-fc52dn3v 299 37 polymorphic polymorphic JJ cord-355239-fc52dn3v 299 38 Cryptosporidium cryptosporidium NN cord-355239-fc52dn3v 299 39 parvum parvum NN cord-355239-fc52dn3v 299 40 gene gene NN cord-355239-fc52dn3v 299 41 encoding encode VBG cord-355239-fc52dn3v 299 42 a a DT cord-355239-fc52dn3v 299 43 60-kilodalton 60-kilodalton CD cord-355239-fc52dn3v 299 44 glycoprotein glycoprotein NN cord-355239-fc52dn3v 299 45 and and CC cord-355239-fc52dn3v 299 46 characterization characterization NN cord-355239-fc52dn3v 299 47 of of IN cord-355239-fc52dn3v 299 48 its -PRON- PRP$ cord-355239-fc52dn3v 299 49 15-and 15-and CD cord-355239-fc52dn3v 299 50 45-kilodalton 45-kilodalton CD cord-355239-fc52dn3v 299 51 zoite zoite NNP cord-355239-fc52dn3v 299 52 surface surface NN cord-355239-fc52dn3v 299 53 antigen antigen NN cord-355239-fc52dn3v 299 54 products product NNS cord-355239-fc52dn3v 299 55 Toll toll NN cord-355239-fc52dn3v 299 56 - - HYPH cord-355239-fc52dn3v 299 57 like like JJ cord-355239-fc52dn3v 299 58 receptor receptor NN cord-355239-fc52dn3v 299 59 recognition recognition NN cord-355239-fc52dn3v 299 60 of of IN cord-355239-fc52dn3v 299 61 Toxoplasma Toxoplasma NNP cord-355239-fc52dn3v 299 62 gondii gondii NN cord-355239-fc52dn3v 299 63 Signaling signaling NN cord-355239-fc52dn3v 299 64 of of IN cord-355239-fc52dn3v 299 65 immune immune JJ cord-355239-fc52dn3v 299 66 system system NN cord-355239-fc52dn3v 299 67 cells cell NNS cord-355239-fc52dn3v 299 68 by by IN cord-355239-fc52dn3v 299 69 glycosylphosphatidylinositol glycosylphosphatidylinositol NNP cord-355239-fc52dn3v 299 70 ( ( -LRB- cord-355239-fc52dn3v 299 71 GPI GPI NNP cord-355239-fc52dn3v 299 72 ) ) -RRB- cord-355239-fc52dn3v 299 73 anchor anchor NN cord-355239-fc52dn3v 299 74 and and CC cord-355239-fc52dn3v 299 75 related related JJ cord-355239-fc52dn3v 299 76 structures structure NNS cord-355239-fc52dn3v 299 77 derived derive VBN cord-355239-fc52dn3v 299 78 from from IN cord-355239-fc52dn3v 299 79 parasitic parasitic JJ cord-355239-fc52dn3v 299 80 protozoa protozoan NNS cord-355239-fc52dn3v 299 81 Impaired impaired JJ cord-355239-fc52dn3v 299 82 production production NN cord-355239-fc52dn3v 299 83 of of IN cord-355239-fc52dn3v 299 84 proinflammatory proinflammatory JJ cord-355239-fc52dn3v 299 85 cytokines cytokine NNS cord-355239-fc52dn3v 299 86 and and CC cord-355239-fc52dn3v 299 87 host host NN cord-355239-fc52dn3v 299 88 resistance resistance NN cord-355239-fc52dn3v 299 89 to to IN cord-355239-fc52dn3v 299 90 acute acute JJ cord-355239-fc52dn3v 299 91 infection infection NN cord-355239-fc52dn3v 299 92 with with IN cord-355239-fc52dn3v 299 93 Trypanosoma Trypanosoma NNP cord-355239-fc52dn3v 299 94 cruzi cruzi NNP cord-355239-fc52dn3v 299 95 in in IN cord-355239-fc52dn3v 299 96 mice mouse NNS cord-355239-fc52dn3v 299 97 lacking lack VBG cord-355239-fc52dn3v 299 98 functional functional JJ cord-355239-fc52dn3v 299 99 myeloid myeloid JJ cord-355239-fc52dn3v 299 100 differentiation differentiation NN cord-355239-fc52dn3v 299 101 factor factor NN cord-355239-fc52dn3v 299 102 88 88 CD cord-355239-fc52dn3v 299 103 Induction induction NN cord-355239-fc52dn3v 299 104 of of IN cord-355239-fc52dn3v 299 105 proinflammatory proinflammatory JJ cord-355239-fc52dn3v 299 106 responses response NNS cord-355239-fc52dn3v 299 107 in in IN cord-355239-fc52dn3v 299 108 macrophages macrophage NNS cord-355239-fc52dn3v 299 109 by by IN cord-355239-fc52dn3v 299 110 the the DT cord-355239-fc52dn3v 299 111 glycosylphosphatidylinositols glycosylphosphatidylinositol NNS cord-355239-fc52dn3v 299 112 of of IN cord-355239-fc52dn3v 299 113 Plasmodium Plasmodium NNP cord-355239-fc52dn3v 299 114 falciparum falciparum NNS cord-355239-fc52dn3v 299 115 : : : cord-355239-fc52dn3v 299 116 cell cell NN cord-355239-fc52dn3v 299 117 signaling signal VBG cord-355239-fc52dn3v 299 118 receptors receptor NNS cord-355239-fc52dn3v 299 119 , , , cord-355239-fc52dn3v 299 120 glycosylphosphatidylinositol glycosylphosphatidylinositol NNP cord-355239-fc52dn3v 299 121 ( ( -LRB- cord-355239-fc52dn3v 299 122 GPI GPI NNP cord-355239-fc52dn3v 299 123 ) ) -RRB- cord-355239-fc52dn3v 299 124 structural structural JJ cord-355239-fc52dn3v 299 125 requirement requirement NN cord-355239-fc52dn3v 299 126 , , , cord-355239-fc52dn3v 299 127 and and CC cord-355239-fc52dn3v 299 128 regulation regulation NN cord-355239-fc52dn3v 299 129 of of IN cord-355239-fc52dn3v 299 130 GPI GPI NNP cord-355239-fc52dn3v 299 131 activity activity NN cord-355239-fc52dn3v 299 132 Activation Activation NNP cord-355239-fc52dn3v 299 133 of of IN cord-355239-fc52dn3v 299 134 TLR2 TLR2 NNP cord-355239-fc52dn3v 299 135 and and CC cord-355239-fc52dn3v 299 136 TLR4 TLR4 NNP cord-355239-fc52dn3v 299 137 by by IN cord-355239-fc52dn3v 299 138 glycosylphosphatidylinositols glycosylphosphatidylinositol NNS cord-355239-fc52dn3v 299 139 derived derive VBN cord-355239-fc52dn3v 299 140 from from IN cord-355239-fc52dn3v 299 141 Toxoplasma Toxoplasma NNP cord-355239-fc52dn3v 299 142 gondii gondii NNP cord-355239-fc52dn3v 299 143 Tissue tissue NN cord-355239-fc52dn3v 299 144 distribution distribution NN cord-355239-fc52dn3v 299 145 of of IN cord-355239-fc52dn3v 299 146 histo histo JJ cord-355239-fc52dn3v 299 147 - - HYPH cord-355239-fc52dn3v 299 148 blood blood NN cord-355239-fc52dn3v 299 149 group group NN cord-355239-fc52dn3v 299 150 antigens antigen NNS cord-355239-fc52dn3v 299 151 Genetic genetic JJ cord-355239-fc52dn3v 299 152 analysis analysis NN cord-355239-fc52dn3v 299 153 of of IN cord-355239-fc52dn3v 299 154 proteoglycan proteoglycan JJ cord-355239-fc52dn3v 299 155 structure structure NN cord-355239-fc52dn3v 299 156 , , , cord-355239-fc52dn3v 299 157 function function NN cord-355239-fc52dn3v 299 158 and and CC cord-355239-fc52dn3v 299 159 metabolism metabolism NN cord-355239-fc52dn3v 300 1 Microbial microbial JJ cord-355239-fc52dn3v 300 2 adherence adherence NN cord-355239-fc52dn3v 300 3 to to IN cord-355239-fc52dn3v 300 4 and and CC cord-355239-fc52dn3v 300 5 invasion invasion NN cord-355239-fc52dn3v 300 6 through through IN cord-355239-fc52dn3v 300 7 proteoglycans proteoglycan NNS cord-355239-fc52dn3v 300 8 Biological biological JJ cord-355239-fc52dn3v 300 9 roles role NNS cord-355239-fc52dn3v 300 10 of of IN cord-355239-fc52dn3v 300 11 oligosaccharides oligosaccharide NNS cord-355239-fc52dn3v 301 1 : : : cord-355239-fc52dn3v 301 2 all all DT cord-355239-fc52dn3v 301 3 of of IN cord-355239-fc52dn3v 301 4 the the DT cord-355239-fc52dn3v 301 5 theories theory NNS cord-355239-fc52dn3v 301 6 are be VBP cord-355239-fc52dn3v 301 7 correct correct JJ cord-355239-fc52dn3v 301 8 Mucins mucin NNS cord-355239-fc52dn3v 301 9 in in IN cord-355239-fc52dn3v 301 10 the the DT cord-355239-fc52dn3v 301 11 mucosal mucosal JJ cord-355239-fc52dn3v 301 12 barrier barrier NN cord-355239-fc52dn3v 301 13 to to IN cord-355239-fc52dn3v 301 14 infection infection NN cord-355239-fc52dn3v 302 1 The the DT cord-355239-fc52dn3v 302 2 adherent adherent JJ cord-355239-fc52dn3v 302 3 gastrointestinal gastrointestinal JJ cord-355239-fc52dn3v 302 4 mucus mucus NN cord-355239-fc52dn3v 302 5 gel gel NN cord-355239-fc52dn3v 302 6 layer layer NN cord-355239-fc52dn3v 302 7 : : : cord-355239-fc52dn3v 302 8 thickness thickness NN cord-355239-fc52dn3v 302 9 and and CC cord-355239-fc52dn3v 302 10 physical physical JJ cord-355239-fc52dn3v 302 11 state state NN cord-355239-fc52dn3v 302 12 in in IN cord-355239-fc52dn3v 302 13 vivo vivo NNP cord-355239-fc52dn3v 302 14 A a DT cord-355239-fc52dn3v 302 15 novel novel JJ cord-355239-fc52dn3v 302 16 method method NN cord-355239-fc52dn3v 302 17 for for IN cord-355239-fc52dn3v 302 18 the the DT cord-355239-fc52dn3v 302 19 visualization visualization NN cord-355239-fc52dn3v 302 20 of of IN cord-355239-fc52dn3v 302 21 the the DT cord-355239-fc52dn3v 302 22 in in IN cord-355239-fc52dn3v 302 23 situ situ JJ cord-355239-fc52dn3v 302 24 mucus mucus NN cord-355239-fc52dn3v 302 25 layer layer NN cord-355239-fc52dn3v 302 26 in in IN cord-355239-fc52dn3v 302 27 rat rat NN cord-355239-fc52dn3v 302 28 and and CC cord-355239-fc52dn3v 302 29 man man NN cord-355239-fc52dn3v 302 30 Colonic colonic JJ cord-355239-fc52dn3v 302 31 mucin mucin NN cord-355239-fc52dn3v 302 32 : : : cord-355239-fc52dn3v 302 33 methods method NNS cord-355239-fc52dn3v 302 34 of of IN cord-355239-fc52dn3v 302 35 measuring measure VBG cord-355239-fc52dn3v 302 36 mucus mucus NN cord-355239-fc52dn3v 302 37 thickness thickness NN cord-355239-fc52dn3v 302 38 Functional functional JJ cord-355239-fc52dn3v 302 39 morphology morphology NN cord-355239-fc52dn3v 302 40 of of IN cord-355239-fc52dn3v 302 41 the the DT cord-355239-fc52dn3v 302 42 mucosa mucosa NN cord-355239-fc52dn3v 302 43 of of IN cord-355239-fc52dn3v 302 44 the the DT cord-355239-fc52dn3v 302 45 small small JJ cord-355239-fc52dn3v 302 46 intestine intestine NN cord-355239-fc52dn3v 303 1 N n NN cord-355239-fc52dn3v 303 2 - - HYPH cord-355239-fc52dn3v 303 3 glycosylation glycosylation NN cord-355239-fc52dn3v 303 4 is be VBZ cord-355239-fc52dn3v 303 5 required require VBN cord-355239-fc52dn3v 303 6 for for IN cord-355239-fc52dn3v 303 7 the the DT cord-355239-fc52dn3v 303 8 surface surface NN cord-355239-fc52dn3v 303 9 localization localization NN cord-355239-fc52dn3v 303 10 of of IN cord-355239-fc52dn3v 303 11 MUC17 MUC17 NNP cord-355239-fc52dn3v 303 12 mucin mucin NN cord-355239-fc52dn3v 303 13 Characterization characterization NN cord-355239-fc52dn3v 303 14 of of IN cord-355239-fc52dn3v 303 15 the the DT cord-355239-fc52dn3v 303 16 oligosaccharides oligosaccharide NNS cord-355239-fc52dn3v 303 17 associated associate VBN cord-355239-fc52dn3v 303 18 with with IN cord-355239-fc52dn3v 303 19 the the DT cord-355239-fc52dn3v 303 20 human human JJ cord-355239-fc52dn3v 303 21 ovarian ovarian JJ cord-355239-fc52dn3v 303 22 tumor tumor NN cord-355239-fc52dn3v 303 23 marker marker NN cord-355239-fc52dn3v 303 24 CA125 CA125 NNP cord-355239-fc52dn3v 303 25 Roles role NNS cord-355239-fc52dn3v 303 26 of of IN cord-355239-fc52dn3v 303 27 calreticulin calreticulin NNP cord-355239-fc52dn3v 303 28 and and CC cord-355239-fc52dn3v 303 29 calnexin calnexin NNP cord-355239-fc52dn3v 303 30 during during IN cord-355239-fc52dn3v 303 31 mucin mucin NN cord-355239-fc52dn3v 303 32 synthesis synthesis NN cord-355239-fc52dn3v 303 33 in in IN cord-355239-fc52dn3v 303 34 LS180 LS180 NNP cord-355239-fc52dn3v 303 35 and and CC cord-355239-fc52dn3v 303 36 HT29 HT29 NNP cord-355239-fc52dn3v 303 37 / / SYM cord-355239-fc52dn3v 303 38 A1 A1 NNP cord-355239-fc52dn3v 303 39 human human JJ cord-355239-fc52dn3v 303 40 colonic colonic JJ cord-355239-fc52dn3v 303 41 adenocarcinoma adenocarcinoma NN cord-355239-fc52dn3v 303 42 cells cell NNS cord-355239-fc52dn3v 303 43 Kinetic Kinetic NNP cord-355239-fc52dn3v 303 44 modeling modeling NN cord-355239-fc52dn3v 303 45 confirms confirm VBZ cord-355239-fc52dn3v 303 46 the the DT cord-355239-fc52dn3v 303 47 biosynthesis biosynthesis NN cord-355239-fc52dn3v 303 48 of of IN cord-355239-fc52dn3v 303 49 mucin mucin NN cord-355239-fc52dn3v 303 50 core core NN cord-355239-fc52dn3v 303 51 1 1 CD cord-355239-fc52dn3v 303 52 ( ( -LRB- cord-355239-fc52dn3v 303 53 beta beta NN cord-355239-fc52dn3v 303 54 - - HYPH cord-355239-fc52dn3v 303 55 Gal(1 gal(1 NN cord-355239-fc52dn3v 303 56 - - HYPH cord-355239-fc52dn3v 303 57 3 3 CD cord-355239-fc52dn3v 303 58 ) ) -RRB- cord-355239-fc52dn3v 304 1 alpha alpha JJ cord-355239-fc52dn3v 304 2 - - HYPH cord-355239-fc52dn3v 304 3 GalNAc galnac NN cord-355239-fc52dn3v 304 4 - - HYPH cord-355239-fc52dn3v 304 5 O O NNP cord-355239-fc52dn3v 304 6 - - HYPH cord-355239-fc52dn3v 304 7 Ser Ser NNP cord-355239-fc52dn3v 304 8 / / SYM cord-355239-fc52dn3v 304 9 Thr Thr NNP cord-355239-fc52dn3v 304 10 ) ) -RRB- cord-355239-fc52dn3v 304 11 O o NN cord-355239-fc52dn3v 304 12 - - HYPH cord-355239-fc52dn3v 304 13 glycan glycan NN cord-355239-fc52dn3v 304 14 structures structure NNS cord-355239-fc52dn3v 304 15 are be VBP cord-355239-fc52dn3v 304 16 modulated modulate VBN cord-355239-fc52dn3v 304 17 by by IN cord-355239-fc52dn3v 304 18 neighboring neighbor VBG cord-355239-fc52dn3v 304 19 glycosylation glycosylation NN cord-355239-fc52dn3v 304 20 effects effect NNS cord-355239-fc52dn3v 304 21 Biology biology NN cord-355239-fc52dn3v 304 22 of of IN cord-355239-fc52dn3v 304 23 the the DT cord-355239-fc52dn3v 304 24 syndecans syndecan NNS cord-355239-fc52dn3v 304 25 : : : cord-355239-fc52dn3v 304 26 a a DT cord-355239-fc52dn3v 304 27 family family NN cord-355239-fc52dn3v 304 28 of of IN cord-355239-fc52dn3v 304 29 transmembrane transmembrane NN cord-355239-fc52dn3v 304 30 heparan heparan NN cord-355239-fc52dn3v 304 31 sulfate sulfate NN cord-355239-fc52dn3v 304 32 proteoglycans proteoglycan VBZ cord-355239-fc52dn3v 304 33 Integral integral JJ cord-355239-fc52dn3v 304 34 membrane membrane NN cord-355239-fc52dn3v 304 35 heparan heparan NN cord-355239-fc52dn3v 304 36 sulfate sulfate NN cord-355239-fc52dn3v 304 37 proteoglycans proteoglycan VBZ cord-355239-fc52dn3v 304 38 Glycolipids Glycolipids NNP cord-355239-fc52dn3v 304 39 at at IN cord-355239-fc52dn3v 304 40 the the DT cord-355239-fc52dn3v 304 41 cell cell NN cord-355239-fc52dn3v 304 42 surface surface NN cord-355239-fc52dn3v 304 43 and and CC cord-355239-fc52dn3v 304 44 their -PRON- PRP$ cord-355239-fc52dn3v 304 45 biological biological JJ cord-355239-fc52dn3v 304 46 functions function NNS cord-355239-fc52dn3v 304 47 Studies Studies NNPS cord-355239-fc52dn3v 304 48 on on IN cord-355239-fc52dn3v 304 49 the the DT cord-355239-fc52dn3v 304 50 molecular molecular JJ cord-355239-fc52dn3v 304 51 mechanism mechanism NN cord-355239-fc52dn3v 304 52 of of IN cord-355239-fc52dn3v 304 53 anion anion NN cord-355239-fc52dn3v 304 54 transport transport NN cord-355239-fc52dn3v 304 55 across across IN cord-355239-fc52dn3v 304 56 the the DT cord-355239-fc52dn3v 304 57 red red JJ cord-355239-fc52dn3v 304 58 blood blood NN cord-355239-fc52dn3v 304 59 cell cell NN cord-355239-fc52dn3v 304 60 membrane membrane NN cord-355239-fc52dn3v 305 1 The the DT cord-355239-fc52dn3v 305 2 composition composition NN cord-355239-fc52dn3v 305 3 and and CC cord-355239-fc52dn3v 305 4 function function NN cord-355239-fc52dn3v 305 5 of of IN cord-355239-fc52dn3v 305 6 M M NNP cord-355239-fc52dn3v 305 7 cell cell NN cord-355239-fc52dn3v 305 8 apical apical JJ cord-355239-fc52dn3v 305 9 membranes membrane NNS cord-355239-fc52dn3v 305 10 : : : cord-355239-fc52dn3v 305 11 implications implication NNS cord-355239-fc52dn3v 305 12 for for IN cord-355239-fc52dn3v 305 13 microbial microbial JJ cord-355239-fc52dn3v 305 14 pathogenesis pathogenesis NN cord-355239-fc52dn3v 305 15 M m CD cord-355239-fc52dn3v 305 16 cells cell NNS cord-355239-fc52dn3v 305 17 and and CC cord-355239-fc52dn3v 305 18 the the DT cord-355239-fc52dn3v 305 19 pathogenesis pathogenesis NN cord-355239-fc52dn3v 305 20 of of IN cord-355239-fc52dn3v 305 21 mucosal mucosal JJ cord-355239-fc52dn3v 305 22 and and CC cord-355239-fc52dn3v 305 23 systemic systemic JJ cord-355239-fc52dn3v 305 24 infections infection NNS cord-355239-fc52dn3v 305 25 Epithelial epithelial JJ cord-355239-fc52dn3v 305 26 M M NNP cord-355239-fc52dn3v 305 27 cells cell NNS cord-355239-fc52dn3v 305 28 : : : cord-355239-fc52dn3v 305 29 differentiation differentiation NN cord-355239-fc52dn3v 305 30 and and CC cord-355239-fc52dn3v 305 31 function function NN cord-355239-fc52dn3v 306 1 Glycoprotein glycoprotein NN cord-355239-fc52dn3v 306 2 2 2 CD cord-355239-fc52dn3v 306 3 ( ( -LRB- cord-355239-fc52dn3v 306 4 GP2 GP2 NNP cord-355239-fc52dn3v 306 5 ) ) -RRB- cord-355239-fc52dn3v 306 6 : : : cord-355239-fc52dn3v 306 7 grabbing grab VBG cord-355239-fc52dn3v 306 8 the the DT cord-355239-fc52dn3v 306 9 FimH FimH NNP cord-355239-fc52dn3v 306 10 bacteria bacteria NNS cord-355239-fc52dn3v 306 11 into into IN cord-355239-fc52dn3v 306 12 M M NNP cord-355239-fc52dn3v 306 13 cells cell NNS cord-355239-fc52dn3v 306 14 for for IN cord-355239-fc52dn3v 306 15 mucosal mucosal JJ cord-355239-fc52dn3v 306 16 immunity immunity NN cord-355239-fc52dn3v 306 17 Uptake uptake NN cord-355239-fc52dn3v 306 18 and and CC cord-355239-fc52dn3v 306 19 transport transport NN cord-355239-fc52dn3v 306 20 of of IN cord-355239-fc52dn3v 306 21 intestinal intestinal JJ cord-355239-fc52dn3v 306 22 macromolecules macromolecule NNS cord-355239-fc52dn3v 306 23 and and CC cord-355239-fc52dn3v 306 24 microorganisms microorganism NNS cord-355239-fc52dn3v 306 25 by by IN cord-355239-fc52dn3v 306 26 M M NNP cord-355239-fc52dn3v 306 27 cells cell NNS cord-355239-fc52dn3v 306 28 in in IN cord-355239-fc52dn3v 306 29 Peyer Peyer NNP cord-355239-fc52dn3v 306 30 's 's POS cord-355239-fc52dn3v 306 31 patches patch NNS cord-355239-fc52dn3v 306 32 -a -a : cord-355239-fc52dn3v 306 33 personal personal JJ cord-355239-fc52dn3v 306 34 and and CC cord-355239-fc52dn3v 306 35 historical historical JJ cord-355239-fc52dn3v 306 36 perspective perspective NN cord-355239-fc52dn3v 306 37 Structure structure NN cord-355239-fc52dn3v 306 38 and and CC cord-355239-fc52dn3v 306 39 functon functon NN cord-355239-fc52dn3v 306 40 of of IN cord-355239-fc52dn3v 306 41 intestinal intestinal JJ cord-355239-fc52dn3v 306 42 mucosal mucosal JJ cord-355239-fc52dn3v 306 43 eptihelium eptihelium NNP cord-355239-fc52dn3v 306 44 Uptake Uptake NNP cord-355239-fc52dn3v 306 45 through through IN cord-355239-fc52dn3v 306 46 glycoprotein glycoprotein NN cord-355239-fc52dn3v 306 47 2 2 CD cord-355239-fc52dn3v 306 48 of of IN cord-355239-fc52dn3v 306 49 FimH(+ fimh(+ NN cord-355239-fc52dn3v 306 50 ) ) -RRB- cord-355239-fc52dn3v 307 1 bacteria bacteria NNS cord-355239-fc52dn3v 307 2 by by IN cord-355239-fc52dn3v 307 3 M M NNP cord-355239-fc52dn3v 307 4 cells cell NNS cord-355239-fc52dn3v 307 5 initiates initiate VBZ cord-355239-fc52dn3v 307 6 mucosal mucosal JJ cord-355239-fc52dn3v 307 7 immune immune JJ cord-355239-fc52dn3v 307 8 response response NN cord-355239-fc52dn3v 307 9 Bacterial bacterial JJ cord-355239-fc52dn3v 307 10 adhesion adhesion NN cord-355239-fc52dn3v 307 11 and and CC cord-355239-fc52dn3v 307 12 entry entry NN cord-355239-fc52dn3v 307 13 into into IN cord-355239-fc52dn3v 307 14 host host NN cord-355239-fc52dn3v 307 15 cells cell NNS cord-355239-fc52dn3v 307 16 Entry Entry NNP cord-355239-fc52dn3v 307 17 of of IN cord-355239-fc52dn3v 307 18 microbes microbe NNS cord-355239-fc52dn3v 307 19 into into IN cord-355239-fc52dn3v 307 20 the the DT cord-355239-fc52dn3v 307 21 host host NN cord-355239-fc52dn3v 307 22 : : : cord-355239-fc52dn3v 307 23 using use VBG cord-355239-fc52dn3v 307 24 M M NNP cord-355239-fc52dn3v 307 25 cells cell NNS cord-355239-fc52dn3v 307 26 to to TO cord-355239-fc52dn3v 307 27 break break VB cord-355239-fc52dn3v 307 28 the the DT cord-355239-fc52dn3v 307 29 mucosal mucosal JJ cord-355239-fc52dn3v 307 30 barrier barrier NN cord-355239-fc52dn3v 307 31 Cellular cellular JJ cord-355239-fc52dn3v 307 32 routes route NNS cord-355239-fc52dn3v 307 33 of of IN cord-355239-fc52dn3v 307 34 invasion invasion NN cord-355239-fc52dn3v 307 35 by by IN cord-355239-fc52dn3v 307 36 enteropathogens enteropathogens NNP cord-355239-fc52dn3v 307 37 Salmonella Salmonella NNP cord-355239-fc52dn3v 307 38 and and CC cord-355239-fc52dn3v 307 39 produce produce VB cord-355239-fc52dn3v 307 40 : : : cord-355239-fc52dn3v 307 41 survival survival NN cord-355239-fc52dn3v 307 42 in in IN cord-355239-fc52dn3v 307 43 the the DT cord-355239-fc52dn3v 307 44 plant plant NN cord-355239-fc52dn3v 307 45 environment environment NN cord-355239-fc52dn3v 307 46 and and CC cord-355239-fc52dn3v 307 47 implications implication NNS cord-355239-fc52dn3v 307 48 in in IN cord-355239-fc52dn3v 307 49 food food NN cord-355239-fc52dn3v 307 50 safety safety NN cord-355239-fc52dn3v 307 51 Neuraminidase Neuraminidase NNP cord-355239-fc52dn3v 307 52 inhibitors inhibitor NNS cord-355239-fc52dn3v 307 53 for for IN cord-355239-fc52dn3v 307 54 influenza influenza NN cord-355239-fc52dn3v 307 55 B b NN cord-355239-fc52dn3v 307 56 virus virus NN cord-355239-fc52dn3v 307 57 infection infection NN cord-355239-fc52dn3v 307 58 : : : cord-355239-fc52dn3v 307 59 efficacy efficacy NN cord-355239-fc52dn3v 307 60 and and CC cord-355239-fc52dn3v 307 61 resistance resistance NN cord-355239-fc52dn3v 307 62 Lipotechoic Lipotechoic NNP cord-355239-fc52dn3v 307 63 acid acid NN cord-355239-fc52dn3v 307 64 in in IN cord-355239-fc52dn3v 307 65 lactobacilli lactobacilli NN cord-355239-fc52dn3v 307 66 : : : cord-355239-fc52dn3v 307 67 D D NNP cord-355239-fc52dn3v 307 68 - - HYPH cord-355239-fc52dn3v 307 69 alanine alanine NNP cord-355239-fc52dn3v 307 70 makes make VBZ cord-355239-fc52dn3v 307 71 the the DT cord-355239-fc52dn3v 307 72 difference difference NN cord-355239-fc52dn3v 307 73 Structure structure NN cord-355239-fc52dn3v 307 74 - - HYPH cord-355239-fc52dn3v 307 75 function function NN cord-355239-fc52dn3v 307 76 relationship relationship NN cord-355239-fc52dn3v 307 77 of of IN cord-355239-fc52dn3v 307 78 cytokine cytokine NN cord-355239-fc52dn3v 307 79 induction induction NN cord-355239-fc52dn3v 307 80 by by IN cord-355239-fc52dn3v 307 81 lipoteichoic lipoteichoic NNP cord-355239-fc52dn3v 307 82 acid acid NN cord-355239-fc52dn3v 307 83 from from IN cord-355239-fc52dn3v 307 84 Staphylococcus Staphylococcus NNP cord-355239-fc52dn3v 307 85 aureus aureus NN cord-355239-fc52dn3v 307 86 Effects effect NNS cord-355239-fc52dn3v 307 87 of of IN cord-355239-fc52dn3v 307 88 dextran dextran NN cord-355239-fc52dn3v 307 89 sulfates sulfate NNS cord-355239-fc52dn3v 307 90 on on IN cord-355239-fc52dn3v 307 91 the the DT cord-355239-fc52dn3v 307 92 acute acute JJ cord-355239-fc52dn3v 307 93 infection infection NN cord-355239-fc52dn3v 307 94 and and CC cord-355239-fc52dn3v 307 95 growth growth NN cord-355239-fc52dn3v 307 96 stages stage NNS cord-355239-fc52dn3v 307 97 of of IN cord-355239-fc52dn3v 307 98 Toxoplasma toxoplasma NN cord-355239-fc52dn3v 307 99 gondii gondii NNP cord-355239-fc52dn3v 307 100 Gellan Gellan NNP cord-355239-fc52dn3v 307 101 sulfate sulfate NN cord-355239-fc52dn3v 307 102 inhibits inhibit VBZ cord-355239-fc52dn3v 307 103 Plasmodium plasmodium NN cord-355239-fc52dn3v 307 104 falciparum falciparum NN cord-355239-fc52dn3v 307 105 growth growth NN cord-355239-fc52dn3v 307 106 and and CC cord-355239-fc52dn3v 307 107 invasion invasion NN cord-355239-fc52dn3v 307 108 of of IN cord-355239-fc52dn3v 307 109 red red JJ cord-355239-fc52dn3v 307 110 blood blood NN cord-355239-fc52dn3v 307 111 cells cell NNS cord-355239-fc52dn3v 308 1 in in IN cord-355239-fc52dn3v 308 2 vitro vitro FW cord-355239-fc52dn3v 309 1 This this DT cord-355239-fc52dn3v 309 2 study study NN cord-355239-fc52dn3v 309 3 was be VBD cord-355239-fc52dn3v 309 4 supported support VBN cord-355239-fc52dn3v 309 5 by by IN cord-355239-fc52dn3v 309 6 Grants grant NNS cord-355239-fc52dn3v 309 7 - - HYPH cord-355239-fc52dn3v 309 8 in in IN cord-355239-fc52dn3v 309 9 - - HYPH cord-355239-fc52dn3v 309 10 Aid aid NN cord-355239-fc52dn3v 309 11 for for IN cord-355239-fc52dn3v 309 12 Young Young NNP cord-355239-fc52dn3v 309 13 Scientists Scientists NNPS cord-355239-fc52dn3v 309 14 , , , cord-355239-fc52dn3v 309 15 and and CC cord-355239-fc52dn3v 309 16 Scientific Scientific NNP cord-355239-fc52dn3v 309 17 Research Research NNP cord-355239-fc52dn3v 309 18 on on IN cord-355239-fc52dn3v 309 19 Innovative Innovative NNP cord-355239-fc52dn3v 309 20 Areas area NNS cord-355239-fc52dn3v 309 21 ( ( -LRB- cord-355239-fc52dn3v 309 22 3308 3308 CD cord-355239-fc52dn3v 309 23 ) ) -RRB- cord-355239-fc52dn3v 309 24 from from IN cord-355239-fc52dn3v 309 25 the the DT cord-355239-fc52dn3v 309 26 Ministry Ministry NNP cord-355239-fc52dn3v 309 27 of of IN cord-355239-fc52dn3v 309 28 Education Education NNP cord-355239-fc52dn3v 309 29 , , , cord-355239-fc52dn3v 309 30 Culture Culture NNP cord-355239-fc52dn3v 309 31 , , , cord-355239-fc52dn3v 309 32 Science Science NNP cord-355239-fc52dn3v 309 33 , , , cord-355239-fc52dn3v 309 34 Sports Sports NNPS cord-355239-fc52dn3v 309 35 , , , cord-355239-fc52dn3v 309 36 and and CC cord-355239-fc52dn3v 309 37 Technology Technology NNP cord-355239-fc52dn3v 309 38 ( ( -LRB- cord-355239-fc52dn3v 309 39 MEXT MEXT NNP cord-355239-fc52dn3v 309 40 ) ) -RRB- cord-355239-fc52dn3v 309 41 and and CC cord-355239-fc52dn3v 309 42 for for IN cord-355239-fc52dn3v 309 43 Research Research NNP cord-355239-fc52dn3v 309 44 on on IN cord-355239-fc52dn3v 309 45 global global JJ cord-355239-fc52dn3v 309 46 health health NN cord-355239-fc52dn3v 309 47 issues issue NNS cord-355239-fc52dn3v 309 48 from from IN cord-355239-fc52dn3v 309 49 the the DT cord-355239-fc52dn3v 309 50 Ministry Ministry NNP cord-355239-fc52dn3v 309 51 of of IN cord-355239-fc52dn3v 309 52 Health Health NNP cord-355239-fc52dn3v 309 53 , , , cord-355239-fc52dn3v 309 54 Labour Labour NNP cord-355239-fc52dn3v 309 55 and and CC cord-355239-fc52dn3v 309 56 Welfare Welfare NNP cord-355239-fc52dn3v 309 57 of of IN cord-355239-fc52dn3v 309 58 Japan Japan NNP cord-355239-fc52dn3v 309 59 , , , cord-355239-fc52dn3v 309 60 the the DT cord-355239-fc52dn3v 309 61 Program Program NNP cord-355239-fc52dn3v 309 62 for for IN cord-355239-fc52dn3v 309 63 Promotion Promotion NNP cord-355239-fc52dn3v 309 64 of of IN cord-355239-fc52dn3v 309 65 Basic Basic NNP cord-355239-fc52dn3v 309 66 and and CC cord-355239-fc52dn3v 309 67 Applied Applied NNP cord-355239-fc52dn3v 309 68 Researches Researches NNPS cord-355239-fc52dn3v 309 69 for for IN cord-355239-fc52dn3v 309 70 Innovations Innovations NNPS cord-355239-fc52dn3v 309 71 in in IN cord-355239-fc52dn3v 309 72 Bio Bio NNP cord-355239-fc52dn3v 309 73 - - HYPH cord-355239-fc52dn3v 309 74 oriented orient VBN cord-355239-fc52dn3v 309 75 Industry Industry NNP cord-355239-fc52dn3v 309 76 ( ( -LRB- cord-355239-fc52dn3v 309 77 BRAIN BRAIN NNP cord-355239-fc52dn3v 309 78 ) ) -RRB- cord-355239-fc52dn3v 309 79 , , , cord-355239-fc52dn3v 309 80 the the DT cord-355239-fc52dn3v 309 81 Science Science NNP cord-355239-fc52dn3v 309 82 and and CC cord-355239-fc52dn3v 309 83 Technology Technology NNP cord-355239-fc52dn3v 309 84 Research Research NNP cord-355239-fc52dn3v 309 85 Promotion Promotion NNP cord-355239-fc52dn3v 309 86 Program Program NNP cord-355239-fc52dn3v 309 87 for for IN cord-355239-fc52dn3v 309 88 Agriculture Agriculture NNP cord-355239-fc52dn3v 309 89 , , , cord-355239-fc52dn3v 309 90 Forestry Forestry NNP cord-355239-fc52dn3v 309 91 , , , cord-355239-fc52dn3v 309 92 Fisheries Fisheries NNP cord-355239-fc52dn3v 309 93 and and CC cord-355239-fc52dn3v 309 94 Food Food NNP cord-355239-fc52dn3v 309 95 Industry Industry NNP cord-355239-fc52dn3v 309 96 , , , cord-355239-fc52dn3v 309 97 The the DT cord-355239-fc52dn3v 309 98 Naito Naito NNP cord-355239-fc52dn3v 309 99 Foundation Foundation NNP cord-355239-fc52dn3v 309 100 , , , cord-355239-fc52dn3v 309 101 and and CC cord-355239-fc52dn3v 309 102 the the DT cord-355239-fc52dn3v 309 103 Program Program NNP cord-355239-fc52dn3v 309 104 to to TO cord-355239-fc52dn3v 309 105 Disseminate disseminate VB cord-355239-fc52dn3v 309 106 Tenure tenure NN cord-355239-fc52dn3v 309 107 Tracking Tracking NNP cord-355239-fc52dn3v 309 108 System system NN cord-355239-fc52dn3v 309 109 from from IN cord-355239-fc52dn3v 309 110 the the DT cord-355239-fc52dn3v 309 111 Japan Japan NNP cord-355239-fc52dn3v 309 112 Science Science NNP cord-355239-fc52dn3v 309 113 and and CC cord-355239-fc52dn3v 309 114 Technology Technology NNP cord-355239-fc52dn3v 309 115 Agency Agency NNP cord-355239-fc52dn3v 309 116 ( ( -LRB- cord-355239-fc52dn3v 309 117 JST JST NNP cord-355239-fc52dn3v 309 118 ) ) -RRB- cord-355239-fc52dn3v 309 119 . . . cord-355239-fc52dn3v 310 1 We -PRON- PRP cord-355239-fc52dn3v 310 2 thank thank VBP cord-355239-fc52dn3v 310 3 Mr. Mr. NNP cord-355239-fc52dn3v 310 4 Tatsuya Tatsuya NNP cord-355239-fc52dn3v 310 5 Iwanaga Iwanaga NNP cord-355239-fc52dn3v 310 6 for for IN cord-355239-fc52dn3v 310 7 his -PRON- PRP$ cord-355239-fc52dn3v 310 8 help help NN cord-355239-fc52dn3v 310 9 with with IN cord-355239-fc52dn3v 310 10 the the DT cord-355239-fc52dn3v 310 11 illustrations illustration NNS cord-355239-fc52dn3v 310 12 . . .