id sid tid token lemma pos cord-319448-gt6uqfrl 1 1 key key NN cord-319448-gt6uqfrl 1 2 : : : cord-319448-gt6uqfrl 2 1 cord-319448-gt6uqfrl cord-319448-gt6uqfrl '' cord-319448-gt6uqfrl 3 1 authors author NNS cord-319448-gt6uqfrl 3 2 : : : cord-319448-gt6uqfrl 3 3 Casadevall Casadevall NNP cord-319448-gt6uqfrl 3 4 , , , cord-319448-gt6uqfrl 3 5 Arturo Arturo NNP cord-319448-gt6uqfrl 3 6 ; ; : cord-319448-gt6uqfrl 3 7 Pirofski Pirofski NNP cord-319448-gt6uqfrl 3 8 , , , cord-319448-gt6uqfrl 3 9 Liise Liise NNP cord-319448-gt6uqfrl 3 10 - - HYPH cord-319448-gt6uqfrl 3 11 anne anne NNP cord-319448-gt6uqfrl 3 12 title title NN cord-319448-gt6uqfrl 3 13 : : : cord-319448-gt6uqfrl 4 1 The the DT cord-319448-gt6uqfrl 4 2 damage damage NN cord-319448-gt6uqfrl 4 3 - - HYPH cord-319448-gt6uqfrl 4 4 response response NN cord-319448-gt6uqfrl 4 5 framework framework NN cord-319448-gt6uqfrl 4 6 of of IN cord-319448-gt6uqfrl 4 7 microbial microbial JJ cord-319448-gt6uqfrl 4 8 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 4 9 date date NN cord-319448-gt6uqfrl 4 10 : : : cord-319448-gt6uqfrl 4 11 2003 2003 CD cord-319448-gt6uqfrl 4 12 journal journal NNP cord-319448-gt6uqfrl 4 13 : : : cord-319448-gt6uqfrl 5 1 Nat Nat NNP cord-319448-gt6uqfrl 5 2 Rev Rev NNP cord-319448-gt6uqfrl 5 3 Microbiol Microbiol NNP cord-319448-gt6uqfrl 5 4 DOI DOI NNP cord-319448-gt6uqfrl 5 5 : : : cord-319448-gt6uqfrl 5 6 10.1038 10.1038 CD cord-319448-gt6uqfrl 5 7 / / SYM cord-319448-gt6uqfrl 5 8 nrmicro732 nrmicro732 NNP cord-319448-gt6uqfrl 5 9 sha sha NNP cord-319448-gt6uqfrl 5 10 : : : cord-319448-gt6uqfrl 6 1 75a206c4a2b9108911451e30ce870694ee8afffb 75a206c4a2b9108911451e30ce870694ee8afffb NNP cord-319448-gt6uqfrl 6 2 doc_id doc_id CD cord-319448-gt6uqfrl 6 3 : : : cord-319448-gt6uqfrl 6 4 319448 319448 CD cord-319448-gt6uqfrl 6 5 cord_uid cord_uid NNS cord-319448-gt6uqfrl 6 6 : : : cord-319448-gt6uqfrl 7 1 gt6uqfrl gt6uqfrl . cord-319448-gt6uqfrl 8 1 The the DT cord-319448-gt6uqfrl 8 2 late late JJ cord-319448-gt6uqfrl 8 3 twentieth twentieth JJ cord-319448-gt6uqfrl 8 4 century century NN cord-319448-gt6uqfrl 8 5 witnessed witness VBD cord-319448-gt6uqfrl 8 6 the the DT cord-319448-gt6uqfrl 8 7 emergence emergence NN cord-319448-gt6uqfrl 8 8 of of IN cord-319448-gt6uqfrl 8 9 numerous numerous JJ cord-319448-gt6uqfrl 8 10 infectious infectious JJ cord-319448-gt6uqfrl 8 11 diseases disease NNS cord-319448-gt6uqfrl 8 12 that that WDT cord-319448-gt6uqfrl 8 13 are be VBP cord-319448-gt6uqfrl 8 14 caused cause VBN cord-319448-gt6uqfrl 8 15 by by IN cord-319448-gt6uqfrl 8 16 microorganisms microorganism NNS cord-319448-gt6uqfrl 8 17 that that WDT cord-319448-gt6uqfrl 8 18 rarely rarely RB cord-319448-gt6uqfrl 8 19 cause cause VBP cord-319448-gt6uqfrl 8 20 disease disease NN cord-319448-gt6uqfrl 8 21 in in IN cord-319448-gt6uqfrl 8 22 normal normal JJ cord-319448-gt6uqfrl 8 23 , , , cord-319448-gt6uqfrl 8 24 healthy healthy JJ cord-319448-gt6uqfrl 8 25 immunocompetent immunocompetent JJ cord-319448-gt6uqfrl 8 26 hosts host NNS cord-319448-gt6uqfrl 8 27 . . . cord-319448-gt6uqfrl 9 1 The the DT cord-319448-gt6uqfrl 9 2 emergence emergence NN cord-319448-gt6uqfrl 9 3 of of IN cord-319448-gt6uqfrl 9 4 these these DT cord-319448-gt6uqfrl 9 5 diseases disease NNS cord-319448-gt6uqfrl 9 6 shows show VBZ cord-319448-gt6uqfrl 9 7 that that IN cord-319448-gt6uqfrl 9 8 the the DT cord-319448-gt6uqfrl 9 9 existing exist VBG cord-319448-gt6uqfrl 9 10 concepts concept NNS cord-319448-gt6uqfrl 9 11 of of IN cord-319448-gt6uqfrl 9 12 pathogenicity pathogenicity NN cord-319448-gt6uqfrl 9 13 and and CC cord-319448-gt6uqfrl 9 14 virulence virulence NN cord-319448-gt6uqfrl 9 15 do do VBP cord-319448-gt6uqfrl 9 16 not not RB cord-319448-gt6uqfrl 9 17 take take VB cord-319448-gt6uqfrl 9 18 into into IN cord-319448-gt6uqfrl 9 19 account account NN cord-319448-gt6uqfrl 9 20 the the DT cord-319448-gt6uqfrl 9 21 fact fact NN cord-319448-gt6uqfrl 9 22 that that IN cord-319448-gt6uqfrl 9 23 both both CC cord-319448-gt6uqfrl 9 24 the the DT cord-319448-gt6uqfrl 9 25 microorganism microorganism NN cord-319448-gt6uqfrl 9 26 and and CC cord-319448-gt6uqfrl 9 27 the the DT cord-319448-gt6uqfrl 9 28 host host NN cord-319448-gt6uqfrl 9 29 contribute contribute VBP cord-319448-gt6uqfrl 9 30 to to IN cord-319448-gt6uqfrl 9 31 microbial microbial JJ cord-319448-gt6uqfrl 9 32 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 9 33 . . . cord-319448-gt6uqfrl 10 1 To to TO cord-319448-gt6uqfrl 10 2 address address VB cord-319448-gt6uqfrl 10 3 this this DT cord-319448-gt6uqfrl 10 4 impediment impediment NN cord-319448-gt6uqfrl 10 5 to to IN cord-319448-gt6uqfrl 10 6 studies study NNS cord-319448-gt6uqfrl 10 7 of of IN cord-319448-gt6uqfrl 10 8 host host NN cord-319448-gt6uqfrl 10 9 – – : cord-319448-gt6uqfrl 10 10 microorganism microorganism NN cord-319448-gt6uqfrl 10 11 interactions interaction NNS cord-319448-gt6uqfrl 10 12 , , , cord-319448-gt6uqfrl 10 13 we -PRON- PRP cord-319448-gt6uqfrl 10 14 propose propose VBP cord-319448-gt6uqfrl 10 15 a a DT cord-319448-gt6uqfrl 10 16 new new JJ cord-319448-gt6uqfrl 10 17 theoretical theoretical JJ cord-319448-gt6uqfrl 10 18 approach approach NN cord-319448-gt6uqfrl 10 19 to to IN cord-319448-gt6uqfrl 10 20 understanding understand VBG cord-319448-gt6uqfrl 10 21 microbial microbial JJ cord-319448-gt6uqfrl 10 22 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 10 23 , , , cord-319448-gt6uqfrl 10 24 known know VBN cord-319448-gt6uqfrl 10 25 as as IN cord-319448-gt6uqfrl 10 26 the the DT cord-319448-gt6uqfrl 10 27 ' ' `` cord-319448-gt6uqfrl 10 28 damage damage NN cord-319448-gt6uqfrl 10 29 - - HYPH cord-319448-gt6uqfrl 10 30 response response NN cord-319448-gt6uqfrl 10 31 ' ' '' cord-319448-gt6uqfrl 10 32 framework framework NN cord-319448-gt6uqfrl 10 33 . . . cord-319448-gt6uqfrl 11 1 The the DT cord-319448-gt6uqfrl 11 2 ' ' `` cord-319448-gt6uqfrl 11 3 damage damage NN cord-319448-gt6uqfrl 11 4 - - HYPH cord-319448-gt6uqfrl 11 5 response response NN cord-319448-gt6uqfrl 11 6 ' ' '' cord-319448-gt6uqfrl 11 7 framework framework NN cord-319448-gt6uqfrl 11 8 of of IN cord-319448-gt6uqfrl 11 9 microbial microbial JJ cord-319448-gt6uqfrl 11 10 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 11 11 is be VBZ cord-319448-gt6uqfrl 11 12 based base VBN cord-319448-gt6uqfrl 11 13 on on IN cord-319448-gt6uqfrl 11 14 three three CD cord-319448-gt6uqfrl 11 15 tenets tenet NNS cord-319448-gt6uqfrl 11 16 1,2 1,2 CD cord-319448-gt6uqfrl 11 17 ( ( -LRB- cord-319448-gt6uqfrl 11 18 BOX box NN cord-319448-gt6uqfrl 11 19 1 1 CD cord-319448-gt6uqfrl 11 20 ) ) -RRB- cord-319448-gt6uqfrl 11 21 . . . cord-319448-gt6uqfrl 12 1 First first RB cord-319448-gt6uqfrl 12 2 , , , cord-319448-gt6uqfrl 12 3 that that IN cord-319448-gt6uqfrl 12 4 microbial microbial JJ cord-319448-gt6uqfrl 12 5 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 12 6 is be VBZ cord-319448-gt6uqfrl 12 7 the the DT cord-319448-gt6uqfrl 12 8 outcome outcome NN cord-319448-gt6uqfrl 12 9 of of IN cord-319448-gt6uqfrl 12 10 an an DT cord-319448-gt6uqfrl 12 11 interaction interaction NN cord-319448-gt6uqfrl 12 12 between between IN cord-319448-gt6uqfrl 12 13 a a DT cord-319448-gt6uqfrl 12 14 HOST host NN cord-319448-gt6uqfrl 12 15 and and CC cord-319448-gt6uqfrl 12 16 a a DT cord-319448-gt6uqfrl 12 17 microorganism microorganism NN cord-319448-gt6uqfrl 12 18 , , , cord-319448-gt6uqfrl 12 19 and and CC cord-319448-gt6uqfrl 12 20 is be VBZ cord-319448-gt6uqfrl 12 21 attributable attributable JJ cord-319448-gt6uqfrl 12 22 to to IN cord-319448-gt6uqfrl 12 23 neither neither CC cord-319448-gt6uqfrl 12 24 the the DT cord-319448-gt6uqfrl 12 25 microorganism microorganism NN cord-319448-gt6uqfrl 12 26 nor nor CC cord-319448-gt6uqfrl 12 27 the the DT cord-319448-gt6uqfrl 12 28 host host NN cord-319448-gt6uqfrl 12 29 alone alone RB cord-319448-gt6uqfrl 12 30 . . . cord-319448-gt6uqfrl 13 1 Second second RB cord-319448-gt6uqfrl 13 2 , , , cord-319448-gt6uqfrl 13 3 that that IN cord-319448-gt6uqfrl 13 4 the the DT cord-319448-gt6uqfrl 13 5 pathological pathological JJ cord-319448-gt6uqfrl 13 6 outcome outcome NN cord-319448-gt6uqfrl 13 7 of of IN cord-319448-gt6uqfrl 13 8 the the DT cord-319448-gt6uqfrl 13 9 hostmicroorganism hostmicroorganism NN cord-319448-gt6uqfrl 13 10 interaction interaction NN cord-319448-gt6uqfrl 13 11 is be VBZ cord-319448-gt6uqfrl 13 12 determined determine VBN cord-319448-gt6uqfrl 13 13 by by IN cord-319448-gt6uqfrl 13 14 the the DT cord-319448-gt6uqfrl 13 15 amount amount NN cord-319448-gt6uqfrl 13 16 of of IN cord-319448-gt6uqfrl 13 17 DAMAGE damage NN cord-319448-gt6uqfrl 13 18 to to IN cord-319448-gt6uqfrl 13 19 the the DT cord-319448-gt6uqfrl 13 20 host host NN cord-319448-gt6uqfrl 13 21 . . . cord-319448-gt6uqfrl 14 1 Third third RB cord-319448-gt6uqfrl 14 2 , , , cord-319448-gt6uqfrl 14 3 that that DT cord-319448-gt6uqfrl 14 4 damage damage NN cord-319448-gt6uqfrl 14 5 to to IN cord-319448-gt6uqfrl 14 6 the the DT cord-319448-gt6uqfrl 14 7 host host NN cord-319448-gt6uqfrl 14 8 can can MD cord-319448-gt6uqfrl 14 9 result result VB cord-319448-gt6uqfrl 14 10 from from IN cord-319448-gt6uqfrl 14 11 microbial microbial JJ cord-319448-gt6uqfrl 14 12 factors factor NNS cord-319448-gt6uqfrl 14 13 and/or and/or CC cord-319448-gt6uqfrl 14 14 the the DT cord-319448-gt6uqfrl 14 15 host host NN cord-319448-gt6uqfrl 14 16 response response NN cord-319448-gt6uqfrl 14 17 . . . cord-319448-gt6uqfrl 15 1 These these DT cord-319448-gt6uqfrl 15 2 tenets tenet NNS cord-319448-gt6uqfrl 15 3 form form VBP cord-319448-gt6uqfrl 15 4 a a DT cord-319448-gt6uqfrl 15 5 scaffold scaffold NN cord-319448-gt6uqfrl 15 6 -or -or : cord-319448-gt6uqfrl 15 7 framework framework NN cord-319448-gt6uqfrl 15 8 -on -on : cord-319448-gt6uqfrl 15 9 which which WDT cord-319448-gt6uqfrl 15 10 a a DT cord-319448-gt6uqfrl 15 11 formal formal JJ cord-319448-gt6uqfrl 15 12 theory theory NN cord-319448-gt6uqfrl 15 13 can can MD cord-319448-gt6uqfrl 15 14 be be VB cord-319448-gt6uqfrl 15 15 built build VBN cord-319448-gt6uqfrl 15 16 and and CC cord-319448-gt6uqfrl 15 17 tested test VBN cord-319448-gt6uqfrl 15 18 . . . cord-319448-gt6uqfrl 16 1 ( ( -LRB- cord-319448-gt6uqfrl 16 2 Glossary glossary JJ cord-319448-gt6uqfrl 16 3 terms term NNS cord-319448-gt6uqfrl 16 4 within within IN cord-319448-gt6uqfrl 16 5 this this DT cord-319448-gt6uqfrl 16 6 article article NN cord-319448-gt6uqfrl 16 7 are be VBP cord-319448-gt6uqfrl 16 8 defined define VBN cord-319448-gt6uqfrl 16 9 as as IN cord-319448-gt6uqfrl 16 10 applied apply VBN cord-319448-gt6uqfrl 16 11 in in IN cord-319448-gt6uqfrl 16 12 the the DT cord-319448-gt6uqfrl 16 13 damage damage NN cord-319448-gt6uqfrl 16 14 - - HYPH cord-319448-gt6uqfrl 16 15 response response NN cord-319448-gt6uqfrl 16 16 framework framework NN cord-319448-gt6uqfrl 16 17 1 1 CD cord-319448-gt6uqfrl 16 18 - - SYM cord-319448-gt6uqfrl 16 19 6 6 CD cord-319448-gt6uqfrl 16 20 . . . cord-319448-gt6uqfrl 16 21 ) ) -RRB- cord-319448-gt6uqfrl 17 1 It -PRON- PRP cord-319448-gt6uqfrl 17 2 is be VBZ cord-319448-gt6uqfrl 17 3 likely likely JJ cord-319448-gt6uqfrl 17 4 that that IN cord-319448-gt6uqfrl 17 5 relationships relationship NNS cord-319448-gt6uqfrl 17 6 have have VBP cord-319448-gt6uqfrl 17 7 existed exist VBN cord-319448-gt6uqfrl 17 8 between between IN cord-319448-gt6uqfrl 17 9 hosts host NNS cord-319448-gt6uqfrl 17 10 and and CC cord-319448-gt6uqfrl 17 11 microorganisms microorganism NNS cord-319448-gt6uqfrl 17 12 for for IN cord-319448-gt6uqfrl 17 13 as as RB cord-319448-gt6uqfrl 17 14 long long RB cord-319448-gt6uqfrl 17 15 as as IN cord-319448-gt6uqfrl 17 16 there there EX cord-319448-gt6uqfrl 17 17 have have VBP cord-319448-gt6uqfrl 17 18 been be VBN cord-319448-gt6uqfrl 17 19 interactions interaction NNS cord-319448-gt6uqfrl 17 20 between between IN cord-319448-gt6uqfrl 17 21 host host NN cord-319448-gt6uqfrl 17 22 and and CC cord-319448-gt6uqfrl 17 23 microbial microbial JJ cord-319448-gt6uqfrl 17 24 cells cell NNS cord-319448-gt6uqfrl 17 25 . . . cord-319448-gt6uqfrl 18 1 Indeed indeed RB cord-319448-gt6uqfrl 18 2 , , , cord-319448-gt6uqfrl 18 3 ancient ancient JJ cord-319448-gt6uqfrl 18 4 host host NN cord-319448-gt6uqfrl 18 5 - - HYPH cord-319448-gt6uqfrl 18 6 microorganism microorganism NN cord-319448-gt6uqfrl 18 7 interactions interaction NNS cord-319448-gt6uqfrl 18 8 , , , cord-319448-gt6uqfrl 18 9 in in IN cord-319448-gt6uqfrl 18 10 which which WDT cord-319448-gt6uqfrl 18 11 bacteria bacteria NNS cord-319448-gt6uqfrl 18 12 were be VBD cord-319448-gt6uqfrl 18 13 incorporated incorporate VBN cord-319448-gt6uqfrl 18 14 into into IN cord-319448-gt6uqfrl 18 15 a a DT cord-319448-gt6uqfrl 18 16 primordial primordial JJ cord-319448-gt6uqfrl 18 17 host host NN cord-319448-gt6uqfrl 18 18 as as IN cord-319448-gt6uqfrl 18 19 organelles organelle NNS cord-319448-gt6uqfrl 18 20 , , , cord-319448-gt6uqfrl 18 21 are be VBP cord-319448-gt6uqfrl 18 22 likely likely JJ cord-319448-gt6uqfrl 18 23 to to TO cord-319448-gt6uqfrl 18 24 have have VB cord-319448-gt6uqfrl 18 25 resulted result VBN cord-319448-gt6uqfrl 18 26 in in IN cord-319448-gt6uqfrl 18 27 the the DT cord-319448-gt6uqfrl 18 28 evolution evolution NN cord-319448-gt6uqfrl 18 29 of of IN cord-319448-gt6uqfrl 18 30 eukaryotes eukaryote NNS cord-319448-gt6uqfrl 18 31 7 7 CD cord-319448-gt6uqfrl 18 32 , , , cord-319448-gt6uqfrl 18 33 8 8 CD cord-319448-gt6uqfrl 18 34 . . . cord-319448-gt6uqfrl 19 1 The the DT cord-319448-gt6uqfrl 19 2 outcome outcome NN cord-319448-gt6uqfrl 19 3 of of IN cord-319448-gt6uqfrl 19 4 many many JJ cord-319448-gt6uqfrl 19 5 hostmicroorganism hostmicroorganism NN cord-319448-gt6uqfrl 19 6 interactions interaction NNS cord-319448-gt6uqfrl 19 7 can can MD cord-319448-gt6uqfrl 19 8 be be VB cord-319448-gt6uqfrl 19 9 either either CC cord-319448-gt6uqfrl 19 10 beneficial beneficial JJ cord-319448-gt6uqfrl 19 11 or or CC cord-319448-gt6uqfrl 19 12 detrimental detrimental JJ cord-319448-gt6uqfrl 19 13 to to IN cord-319448-gt6uqfrl 19 14 the the DT cord-319448-gt6uqfrl 19 15 microorganism microorganism NN cord-319448-gt6uqfrl 19 16 , , , cord-319448-gt6uqfrl 19 17 to to IN cord-319448-gt6uqfrl 19 18 the the DT cord-319448-gt6uqfrl 19 19 host host NN cord-319448-gt6uqfrl 19 20 , , , cord-319448-gt6uqfrl 19 21 or or CC cord-319448-gt6uqfrl 19 22 to to IN cord-319448-gt6uqfrl 19 23 both both PDT cord-319448-gt6uqfrl 19 24 the the DT cord-319448-gt6uqfrl 19 25 microorganism microorganism NN cord-319448-gt6uqfrl 19 26 and and CC cord-319448-gt6uqfrl 19 27 the the DT cord-319448-gt6uqfrl 19 28 host host NN cord-319448-gt6uqfrl 19 29 ( ( -LRB- cord-319448-gt6uqfrl 19 30 TABLE TABLE NNP cord-319448-gt6uqfrl 19 31 1 1 CD cord-319448-gt6uqfrl 19 32 ) ) -RRB- cord-319448-gt6uqfrl 19 33 . . . cord-319448-gt6uqfrl 20 1 MUTUALISM MUTUALISM NNP cord-319448-gt6uqfrl 20 2 and and CC cord-319448-gt6uqfrl 20 3 COMMENSALISM COMMENSALISM NNP cord-319448-gt6uqfrl 20 4 are be VBP cord-319448-gt6uqfrl 20 5 examples example NNS cord-319448-gt6uqfrl 20 6 of of IN cord-319448-gt6uqfrl 20 7 interactions interaction NNS cord-319448-gt6uqfrl 20 8 that that WDT cord-319448-gt6uqfrl 20 9 are be VBP cord-319448-gt6uqfrl 20 10 beneficial beneficial JJ cord-319448-gt6uqfrl 20 11 to to IN cord-319448-gt6uqfrl 20 12 both both CC cord-319448-gt6uqfrl 20 13 the the DT cord-319448-gt6uqfrl 20 14 host host NN cord-319448-gt6uqfrl 20 15 and and CC cord-319448-gt6uqfrl 20 16 the the DT cord-319448-gt6uqfrl 20 17 microorganism microorganism NN cord-319448-gt6uqfrl 20 18 . . . cord-319448-gt6uqfrl 21 1 In in IN cord-319448-gt6uqfrl 21 2 the the DT cord-319448-gt6uqfrl 21 3 case case NN cord-319448-gt6uqfrl 21 4 of of IN cord-319448-gt6uqfrl 21 5 microorganisms microorganism NNS cord-319448-gt6uqfrl 21 6 that that WDT cord-319448-gt6uqfrl 21 7 replicate replicate VBP cord-319448-gt6uqfrl 21 8 within within IN cord-319448-gt6uqfrl 21 9 their -PRON- PRP$ cord-319448-gt6uqfrl 21 10 hosts host NNS cord-319448-gt6uqfrl 21 11 , , , cord-319448-gt6uqfrl 21 12 detrimental detrimental JJ cord-319448-gt6uqfrl 21 13 outcomes outcome NNS cord-319448-gt6uqfrl 21 14 result result VBP cord-319448-gt6uqfrl 21 15 in in IN cord-319448-gt6uqfrl 21 16 the the DT cord-319448-gt6uqfrl 21 17 inability inability NN cord-319448-gt6uqfrl 21 18 to to TO cord-319448-gt6uqfrl 21 19 replicate replicate VB cord-319448-gt6uqfrl 21 20 further further RB cord-319448-gt6uqfrl 21 21 and/or and/or CC cord-319448-gt6uqfrl 21 22 death death NN cord-319448-gt6uqfrl 21 23 . . . cord-319448-gt6uqfrl 22 1 Although although IN cord-319448-gt6uqfrl 22 2 microbial microbial JJ cord-319448-gt6uqfrl 22 3 replication replication NN cord-319448-gt6uqfrl 22 4 can can MD cord-319448-gt6uqfrl 22 5 cause cause VB cord-319448-gt6uqfrl 22 6 host host NN cord-319448-gt6uqfrl 22 7 damage damage NN cord-319448-gt6uqfrl 22 8 , , , cord-319448-gt6uqfrl 22 9 and and CC cord-319448-gt6uqfrl 22 10 possibly possibly RB cord-319448-gt6uqfrl 22 11 DISEASE DISEASE NNP cord-319448-gt6uqfrl 22 12 , , , cord-319448-gt6uqfrl 22 13 host host NN cord-319448-gt6uqfrl 22 14 damage damage NN cord-319448-gt6uqfrl 22 15 and/or and/or CC cord-319448-gt6uqfrl 22 16 disease disease NN cord-319448-gt6uqfrl 22 17 are be VBP cord-319448-gt6uqfrl 22 18 not not RB cord-319448-gt6uqfrl 22 19 essential essential JJ cord-319448-gt6uqfrl 22 20 for for IN cord-319448-gt6uqfrl 22 21 microbial microbial JJ cord-319448-gt6uqfrl 22 22 survival survival NN cord-319448-gt6uqfrl 22 23 . . . cord-319448-gt6uqfrl 23 1 Furthermore furthermore RB cord-319448-gt6uqfrl 23 2 , , , cord-319448-gt6uqfrl 23 3 microbial microbial JJ cord-319448-gt6uqfrl 23 4 viability viability NN cord-319448-gt6uqfrl 23 5 is be VBZ cord-319448-gt6uqfrl 23 6 not not RB cord-319448-gt6uqfrl 23 7 a a DT cord-319448-gt6uqfrl 23 8 requirement requirement NN cord-319448-gt6uqfrl 23 9 for for IN cord-319448-gt6uqfrl 23 10 microbial microbial JJ cord-319448-gt6uqfrl 23 11 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 23 12 . . . cord-319448-gt6uqfrl 24 1 For for IN cord-319448-gt6uqfrl 24 2 example example NN cord-319448-gt6uqfrl 24 3 , , , cord-319448-gt6uqfrl 24 4 cysticercosis cysticercosis NN cord-319448-gt6uqfrl 24 5 -a -a HYPH cord-319448-gt6uqfrl 24 6 devastating devastating JJ cord-319448-gt6uqfrl 24 7 neurological neurological JJ cord-319448-gt6uqfrl 24 8 disease disease NN cord-319448-gt6uqfrl 24 9 that that WDT cord-319448-gt6uqfrl 24 10 is be VBZ cord-319448-gt6uqfrl 24 11 caused cause VBN cord-319448-gt6uqfrl 24 12 by by IN cord-319448-gt6uqfrl 24 13 the the DT cord-319448-gt6uqfrl 24 14 host host NN cord-319448-gt6uqfrl 24 15 inflammatory inflammatory JJ cord-319448-gt6uqfrl 24 16 response response NN cord-319448-gt6uqfrl 24 17 to to IN cord-319448-gt6uqfrl 24 18 the the DT cord-319448-gt6uqfrl 24 19 cestode cestode NNP cord-319448-gt6uqfrl 24 20 Taenia Taenia NNP cord-319448-gt6uqfrl 24 21 solium solium NN cord-319448-gt6uqfrl 24 22 -can -can : cord-319448-gt6uqfrl 24 23 be be VB cord-319448-gt6uqfrl 24 24 precipitated precipitate VBN cord-319448-gt6uqfrl 24 25 by by IN cord-319448-gt6uqfrl 24 26 the the DT cord-319448-gt6uqfrl 24 27 death death NN cord-319448-gt6uqfrl 24 28 of of IN cord-319448-gt6uqfrl 24 29 the the DT cord-319448-gt6uqfrl 24 30 parasite parasite NN cord-319448-gt6uqfrl 24 31 , , , cord-319448-gt6uqfrl 24 32 such such JJ cord-319448-gt6uqfrl 24 33 that that IN cord-319448-gt6uqfrl 24 34 anti anti JJ cord-319448-gt6uqfrl 24 35 - - JJ cord-319448-gt6uqfrl 24 36 helminthic helminthic JJ cord-319448-gt6uqfrl 24 37 therapy therapy NN cord-319448-gt6uqfrl 24 38 is be VBZ cord-319448-gt6uqfrl 24 39 considered consider VBN cord-319448-gt6uqfrl 24 40 to to TO cord-319448-gt6uqfrl 24 41 be be VB cord-319448-gt6uqfrl 24 42 detrimental detrimental JJ cord-319448-gt6uqfrl 24 43 in in IN cord-319448-gt6uqfrl 24 44 certain certain JJ cord-319448-gt6uqfrl 24 45 clinical clinical JJ cord-319448-gt6uqfrl 24 46 situations situation NNS cord-319448-gt6uqfrl 24 47 9 9 CD cord-319448-gt6uqfrl 24 48 . . . cord-319448-gt6uqfrl 25 1 Host host NN cord-319448-gt6uqfrl 25 2 - - HYPH cord-319448-gt6uqfrl 25 3 microorganism microorganism NN cord-319448-gt6uqfrl 25 4 interactions interaction NNS cord-319448-gt6uqfrl 25 5 that that WDT cord-319448-gt6uqfrl 25 6 result result VBP cord-319448-gt6uqfrl 25 7 in in IN cord-319448-gt6uqfrl 25 8 the the DT cord-319448-gt6uqfrl 25 9 clearance clearance NN cord-319448-gt6uqfrl 25 10 and/or and/or CC cord-319448-gt6uqfrl 25 11 control control NN cord-319448-gt6uqfrl 25 12 of of IN cord-319448-gt6uqfrl 25 13 a a DT cord-319448-gt6uqfrl 25 14 microorganism microorganism NN cord-319448-gt6uqfrl 25 15 without without IN cord-319448-gt6uqfrl 25 16 the the DT cord-319448-gt6uqfrl 25 17 development development NN cord-319448-gt6uqfrl 25 18 of of IN cord-319448-gt6uqfrl 25 19 clinically clinically RB cord-319448-gt6uqfrl 25 20 relevant relevant JJ cord-319448-gt6uqfrl 25 21 host host NN cord-319448-gt6uqfrl 25 22 damage damage NN cord-319448-gt6uqfrl 25 23 represent represent VBP cord-319448-gt6uqfrl 25 24 a a DT cord-319448-gt6uqfrl 25 25 basis basis NN cord-319448-gt6uqfrl 25 26 for for IN cord-319448-gt6uqfrl 25 27 the the DT cord-319448-gt6uqfrl 25 28 development development NN cord-319448-gt6uqfrl 25 29 of of IN cord-319448-gt6uqfrl 25 30 vaccines vaccine NNS cord-319448-gt6uqfrl 25 31 and and CC cord-319448-gt6uqfrl 25 32 immune immune JJ cord-319448-gt6uqfrl 25 33 - - HYPH cord-319448-gt6uqfrl 25 34 response response NN cord-319448-gt6uqfrl 25 35 - - HYPH cord-319448-gt6uqfrl 25 36 based base VBN cord-319448-gt6uqfrl 25 37 therapies therapy NNS cord-319448-gt6uqfrl 25 38 for for IN cord-319448-gt6uqfrl 25 39 infectious infectious JJ cord-319448-gt6uqfrl 25 40 diseases disease NNS cord-319448-gt6uqfrl 25 41 . . . cord-319448-gt6uqfrl 26 1 However however RB cord-319448-gt6uqfrl 26 2 , , , cord-319448-gt6uqfrl 26 3 host host NN cord-319448-gt6uqfrl 26 4 - - HYPH cord-319448-gt6uqfrl 26 5 induced induce VBN cord-319448-gt6uqfrl 26 6 cell cell NN cord-319448-gt6uqfrl 26 7 and/or and/or CC cord-319448-gt6uqfrl 26 8 tissue tissue NN cord-319448-gt6uqfrl 26 9 damage damage NN cord-319448-gt6uqfrl 26 10 can can MD cord-319448-gt6uqfrl 26 11 also also RB cord-319448-gt6uqfrl 26 12 produce produce VB cord-319448-gt6uqfrl 26 13 detrimental detrimental JJ cord-319448-gt6uqfrl 26 14 outcomes outcome NNS cord-319448-gt6uqfrl 26 15 , , , cord-319448-gt6uqfrl 26 16 which which WDT cord-319448-gt6uqfrl 26 17 can can MD cord-319448-gt6uqfrl 26 18 result result VB cord-319448-gt6uqfrl 26 19 in in IN cord-319448-gt6uqfrl 26 20 disease disease NN cord-319448-gt6uqfrl 26 21 or or CC cord-319448-gt6uqfrl 26 22 death death NN cord-319448-gt6uqfrl 26 23 -although -although . cord-319448-gt6uqfrl 27 1 certain certain JJ cord-319448-gt6uqfrl 27 2 manifestations manifestation NNS cord-319448-gt6uqfrl 27 3 of of IN cord-319448-gt6uqfrl 27 4 host host NN cord-319448-gt6uqfrl 27 5 damage damage NN cord-319448-gt6uqfrl 27 6 represent represent VBP cord-319448-gt6uqfrl 27 7 the the DT cord-319448-gt6uqfrl 27 8 outcome outcome NN cord-319448-gt6uqfrl 27 9 of of IN cord-319448-gt6uqfrl 27 10 a a DT cord-319448-gt6uqfrl 27 11 successful successful JJ cord-319448-gt6uqfrl 27 12 immune immune JJ cord-319448-gt6uqfrl 27 13 response response NN cord-319448-gt6uqfrl 27 14 to to IN cord-319448-gt6uqfrl 27 15 MICROBIAL microbial JJ cord-319448-gt6uqfrl 27 16 INFECTION infection NN cord-319448-gt6uqfrl 27 17 . . . cord-319448-gt6uqfrl 28 1 Some some DT cord-319448-gt6uqfrl 28 2 interactions interaction NNS cord-319448-gt6uqfrl 28 3 are be VBP cord-319448-gt6uqfrl 28 4 highly highly RB cord-319448-gt6uqfrl 28 5 complex complex JJ cord-319448-gt6uqfrl 28 6 and and CC cord-319448-gt6uqfrl 28 7 illustrate illustrate VBP cord-319448-gt6uqfrl 28 8 the the DT cord-319448-gt6uqfrl 28 9 difficulty difficulty NN cord-319448-gt6uqfrl 28 10 that that WDT cord-319448-gt6uqfrl 28 11 can can MD cord-319448-gt6uqfrl 28 12 be be VB cord-319448-gt6uqfrl 28 13 associated associate VBN cord-319448-gt6uqfrl 28 14 with with IN cord-319448-gt6uqfrl 28 15 discriminating discriminate VBG cord-319448-gt6uqfrl 28 16 between between IN cord-319448-gt6uqfrl 28 17 a a DT cord-319448-gt6uqfrl 28 18 host host NN cord-319448-gt6uqfrl 28 19 and and CC cord-319448-gt6uqfrl 28 20 a a DT cord-319448-gt6uqfrl 28 21 microorganism microorganism NN cord-319448-gt6uqfrl 28 22 . . . cord-319448-gt6uqfrl 29 1 For for IN cord-319448-gt6uqfrl 29 2 example example NN cord-319448-gt6uqfrl 29 3 , , , cord-319448-gt6uqfrl 29 4 the the DT cord-319448-gt6uqfrl 29 5 ingestion ingestion NN cord-319448-gt6uqfrl 29 6 of of IN cord-319448-gt6uqfrl 29 7 certain certain JJ cord-319448-gt6uqfrl 29 8 microorganisms microorganism NNS cord-319448-gt6uqfrl 29 9 by by IN cord-319448-gt6uqfrl 29 10 amoebae amoeba NNS cord-319448-gt6uqfrl 29 11 ( ( -LRB- cord-319448-gt6uqfrl 29 12 the the DT cord-319448-gt6uqfrl 29 13 host host NN cord-319448-gt6uqfrl 29 14 ) ) -RRB- cord-319448-gt6uqfrl 29 15 can can MD cord-319448-gt6uqfrl 29 16 be be VB cord-319448-gt6uqfrl 29 17 beneficial beneficial JJ cord-319448-gt6uqfrl 29 18 to to IN cord-319448-gt6uqfrl 29 19 the the DT cord-319448-gt6uqfrl 29 20 amoebae amoebae NN cord-319448-gt6uqfrl 29 21 , , , cord-319448-gt6uqfrl 29 22 as as IN cord-319448-gt6uqfrl 29 23 the the DT cord-319448-gt6uqfrl 29 24 microorganisms microorganism NNS cord-319448-gt6uqfrl 29 25 are be VBP cord-319448-gt6uqfrl 29 26 a a DT cord-319448-gt6uqfrl 29 27 source source NN cord-319448-gt6uqfrl 29 28 of of IN cord-319448-gt6uqfrl 29 29 food food NN cord-319448-gt6uqfrl 29 30 , , , cord-319448-gt6uqfrl 29 31 and and CC cord-319448-gt6uqfrl 29 32 detrimental detrimental JJ cord-319448-gt6uqfrl 30 1 The the DT cord-319448-gt6uqfrl 30 2 late late JJ cord-319448-gt6uqfrl 30 3 twentieth twentieth JJ cord-319448-gt6uqfrl 30 4 century century NN cord-319448-gt6uqfrl 30 5 witnessed witness VBD cord-319448-gt6uqfrl 30 6 the the DT cord-319448-gt6uqfrl 30 7 emergence emergence NN cord-319448-gt6uqfrl 30 8 of of IN cord-319448-gt6uqfrl 30 9 numerous numerous JJ cord-319448-gt6uqfrl 30 10 infectious infectious JJ cord-319448-gt6uqfrl 30 11 diseases disease NNS cord-319448-gt6uqfrl 30 12 that that WDT cord-319448-gt6uqfrl 30 13 are be VBP cord-319448-gt6uqfrl 30 14 caused cause VBN cord-319448-gt6uqfrl 30 15 by by IN cord-319448-gt6uqfrl 30 16 microorganisms microorganism NNS cord-319448-gt6uqfrl 30 17 that that WDT cord-319448-gt6uqfrl 30 18 rarely rarely RB cord-319448-gt6uqfrl 30 19 cause cause VBP cord-319448-gt6uqfrl 30 20 disease disease NN cord-319448-gt6uqfrl 30 21 in in IN cord-319448-gt6uqfrl 30 22 normal normal JJ cord-319448-gt6uqfrl 30 23 , , , cord-319448-gt6uqfrl 30 24 healthy healthy JJ cord-319448-gt6uqfrl 30 25 immunocompetent immunocompetent JJ cord-319448-gt6uqfrl 30 26 hosts host NNS cord-319448-gt6uqfrl 30 27 . . . cord-319448-gt6uqfrl 31 1 The the DT cord-319448-gt6uqfrl 31 2 emergence emergence NN cord-319448-gt6uqfrl 31 3 of of IN cord-319448-gt6uqfrl 31 4 these these DT cord-319448-gt6uqfrl 31 5 diseases disease NNS cord-319448-gt6uqfrl 31 6 shows show VBZ cord-319448-gt6uqfrl 31 7 that that IN cord-319448-gt6uqfrl 31 8 the the DT cord-319448-gt6uqfrl 31 9 existing exist VBG cord-319448-gt6uqfrl 31 10 concepts concept NNS cord-319448-gt6uqfrl 31 11 of of IN cord-319448-gt6uqfrl 31 12 pathogenicity pathogenicity NN cord-319448-gt6uqfrl 31 13 and and CC cord-319448-gt6uqfrl 31 14 virulence virulence NN cord-319448-gt6uqfrl 31 15 do do VBP cord-319448-gt6uqfrl 31 16 not not RB cord-319448-gt6uqfrl 31 17 take take VB cord-319448-gt6uqfrl 31 18 into into IN cord-319448-gt6uqfrl 31 19 account account NN cord-319448-gt6uqfrl 31 20 the the DT cord-319448-gt6uqfrl 31 21 fact fact NN cord-319448-gt6uqfrl 31 22 that that IN cord-319448-gt6uqfrl 31 23 both both CC cord-319448-gt6uqfrl 31 24 the the DT cord-319448-gt6uqfrl 31 25 microorganism microorganism NN cord-319448-gt6uqfrl 31 26 and and CC cord-319448-gt6uqfrl 31 27 the the DT cord-319448-gt6uqfrl 31 28 host host NN cord-319448-gt6uqfrl 31 29 contribute contribute VBP cord-319448-gt6uqfrl 31 30 to to IN cord-319448-gt6uqfrl 31 31 microbial microbial JJ cord-319448-gt6uqfrl 31 32 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 31 33 . . . cord-319448-gt6uqfrl 32 1 To to TO cord-319448-gt6uqfrl 32 2 address address VB cord-319448-gt6uqfrl 32 3 this this DT cord-319448-gt6uqfrl 32 4 impediment impediment NN cord-319448-gt6uqfrl 32 5 to to IN cord-319448-gt6uqfrl 32 6 studies study NNS cord-319448-gt6uqfrl 32 7 of of IN cord-319448-gt6uqfrl 32 8 host host NN cord-319448-gt6uqfrl 32 9 - - HYPH cord-319448-gt6uqfrl 32 10 microorganism microorganism NN cord-319448-gt6uqfrl 32 11 interactions interaction NNS cord-319448-gt6uqfrl 32 12 , , , cord-319448-gt6uqfrl 32 13 we -PRON- PRP cord-319448-gt6uqfrl 32 14 propose propose VBP cord-319448-gt6uqfrl 32 15 a a DT cord-319448-gt6uqfrl 32 16 new new JJ cord-319448-gt6uqfrl 32 17 theoretical theoretical JJ cord-319448-gt6uqfrl 32 18 approach approach NN cord-319448-gt6uqfrl 32 19 to to IN cord-319448-gt6uqfrl 32 20 understanding understand VBG cord-319448-gt6uqfrl 32 21 microbial microbial JJ cord-319448-gt6uqfrl 32 22 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 32 23 , , , cord-319448-gt6uqfrl 32 24 known know VBN cord-319448-gt6uqfrl 32 25 as as IN cord-319448-gt6uqfrl 32 26 the the DT cord-319448-gt6uqfrl 32 27 ' ' `` cord-319448-gt6uqfrl 32 28 damage damage NN cord-319448-gt6uqfrl 32 29 - - HYPH cord-319448-gt6uqfrl 32 30 response response NN cord-319448-gt6uqfrl 32 31 ' ' '' cord-319448-gt6uqfrl 32 32 framework framework NN cord-319448-gt6uqfrl 32 33 . . . cord-319448-gt6uqfrl 33 1 HOST HOST NNP cord-319448-gt6uqfrl 33 2 An an DT cord-319448-gt6uqfrl 33 3 entity entity NN cord-319448-gt6uqfrl 33 4 in in IN cord-319448-gt6uqfrl 33 5 which which WDT cord-319448-gt6uqfrl 33 6 microorganisms microorganism NNS cord-319448-gt6uqfrl 33 7 reside reside VBP cord-319448-gt6uqfrl 33 8 and/or and/or CC cord-319448-gt6uqfrl 33 9 replicate replicate VB cord-319448-gt6uqfrl 33 10 ; ; : cord-319448-gt6uqfrl 33 11 an an DT cord-319448-gt6uqfrl 33 12 entity entity NN cord-319448-gt6uqfrl 33 13 in in IN cord-319448-gt6uqfrl 33 14 which which WDT cord-319448-gt6uqfrl 33 15 microbial microbial JJ cord-319448-gt6uqfrl 33 16 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 33 17 occurs occur VBZ cord-319448-gt6uqfrl 33 18 . . . cord-319448-gt6uqfrl 34 1 DAMAGE damage NN cord-319448-gt6uqfrl 34 2 Disruptions disruption NNS cord-319448-gt6uqfrl 34 3 in in IN cord-319448-gt6uqfrl 34 4 the the DT cord-319448-gt6uqfrl 34 5 normal normal JJ cord-319448-gt6uqfrl 34 6 homeostatic homeostatic JJ cord-319448-gt6uqfrl 34 7 mechanisms mechanism NNS cord-319448-gt6uqfrl 34 8 of of IN cord-319448-gt6uqfrl 34 9 a a DT cord-319448-gt6uqfrl 34 10 host host NN cord-319448-gt6uqfrl 34 11 that that WDT cord-319448-gt6uqfrl 34 12 alter alter VBP cord-319448-gt6uqfrl 34 13 the the DT cord-319448-gt6uqfrl 34 14 functioning functioning NN cord-319448-gt6uqfrl 34 15 of of IN cord-319448-gt6uqfrl 34 16 cells cell NNS cord-319448-gt6uqfrl 34 17 , , , cord-319448-gt6uqfrl 34 18 tissues tissue NNS cord-319448-gt6uqfrl 34 19 or or CC cord-319448-gt6uqfrl 34 20 organs organ NNS cord-319448-gt6uqfrl 34 21 ; ; : cord-319448-gt6uqfrl 34 22 for for IN cord-319448-gt6uqfrl 34 23 microorganisms microorganism NNS cord-319448-gt6uqfrl 34 24 , , , cord-319448-gt6uqfrl 34 25 disruptions disruption NNS cord-319448-gt6uqfrl 34 26 in in IN cord-319448-gt6uqfrl 34 27 the the DT cord-319448-gt6uqfrl 34 28 normal normal JJ cord-319448-gt6uqfrl 34 29 mechanisms mechanism NNS cord-319448-gt6uqfrl 34 30 that that WDT cord-319448-gt6uqfrl 34 31 enable enable VBP cord-319448-gt6uqfrl 34 32 host host NN cord-319448-gt6uqfrl 34 33 entry entry NN cord-319448-gt6uqfrl 34 34 , , , cord-319448-gt6uqfrl 34 35 replication replication NN cord-319448-gt6uqfrl 34 36 and/or and/or CC cord-319448-gt6uqfrl 34 37 the the DT cord-319448-gt6uqfrl 34 38 ability ability NN cord-319448-gt6uqfrl 34 39 to to TO cord-319448-gt6uqfrl 34 40 establish establish VB cord-319448-gt6uqfrl 34 41 residence residence NN cord-319448-gt6uqfrl 34 42 in in IN cord-319448-gt6uqfrl 34 43 a a DT cord-319448-gt6uqfrl 34 44 host host NN cord-319448-gt6uqfrl 34 45 . . . cord-319448-gt6uqfrl 35 1 infectious infectious JJ cord-319448-gt6uqfrl 35 2 diseases disease NNS cord-319448-gt6uqfrl 35 3 that that WDT cord-319448-gt6uqfrl 35 4 are be VBP cord-319448-gt6uqfrl 35 5 caused cause VBN cord-319448-gt6uqfrl 35 6 by by IN cord-319448-gt6uqfrl 35 7 microorganisms microorganism NNS cord-319448-gt6uqfrl 35 8 that that WDT cord-319448-gt6uqfrl 35 9 have have VBP cord-319448-gt6uqfrl 35 10 been be VBN cord-319448-gt6uqfrl 35 11 referred refer VBN cord-319448-gt6uqfrl 35 12 to to IN cord-319448-gt6uqfrl 35 13 as as IN cord-319448-gt6uqfrl 35 14 ' ' `` cord-319448-gt6uqfrl 35 15 weak weak JJ cord-319448-gt6uqfrl 35 16 ' ' '' cord-319448-gt6uqfrl 35 17 , , , cord-319448-gt6uqfrl 35 18 ' ' `` cord-319448-gt6uqfrl 35 19 non'-pathogens non'-pathogen NNS cord-319448-gt6uqfrl 35 20 or or CC cord-319448-gt6uqfrl 35 21 those those DT cord-319448-gt6uqfrl 35 22 that that WDT cord-319448-gt6uqfrl 35 23 are be VBP cord-319448-gt6uqfrl 35 24 ' ' `` cord-319448-gt6uqfrl 35 25 less less RBR cord-319448-gt6uqfrl 35 26 virulent virulent JJ cord-319448-gt6uqfrl 35 27 ' ' '' cord-319448-gt6uqfrl 35 28 . . . cord-319448-gt6uqfrl 36 1 Similarly similarly RB cord-319448-gt6uqfrl 36 2 , , , cord-319448-gt6uqfrl 36 3 the the DT cord-319448-gt6uqfrl 36 4 concept concept NN cord-319448-gt6uqfrl 36 5 of of IN cord-319448-gt6uqfrl 36 6 microbial microbial JJ cord-319448-gt6uqfrl 36 7 ' ' `` cord-319448-gt6uqfrl 36 8 opportunism opportunism NN cord-319448-gt6uqfrl 36 9 ' ' '' cord-319448-gt6uqfrl 36 10 was be VBD cord-319448-gt6uqfrl 36 11 devised devise VBN cord-319448-gt6uqfrl 36 12 to to TO cord-319448-gt6uqfrl 36 13 explain explain VB cord-319448-gt6uqfrl 36 14 the the DT cord-319448-gt6uqfrl 36 15 emergence emergence NN cord-319448-gt6uqfrl 36 16 of of IN cord-319448-gt6uqfrl 36 17 previously previously RB cord-319448-gt6uqfrl 36 18 rare rare JJ cord-319448-gt6uqfrl 36 19 infectious infectious JJ cord-319448-gt6uqfrl 36 20 diseases disease NNS cord-319448-gt6uqfrl 36 21 in in IN cord-319448-gt6uqfrl 36 22 individuals individual NNS cord-319448-gt6uqfrl 36 23 with with IN cord-319448-gt6uqfrl 36 24 impaired impaired JJ cord-319448-gt6uqfrl 36 25 immunity immunity NN cord-319448-gt6uqfrl 36 26 15 15 CD cord-319448-gt6uqfrl 36 27 , , , cord-319448-gt6uqfrl 36 28 16 16 CD cord-319448-gt6uqfrl 36 29 . . . cord-319448-gt6uqfrl 37 1 However however RB cord-319448-gt6uqfrl 37 2 , , , cord-319448-gt6uqfrl 37 3 the the DT cord-319448-gt6uqfrl 37 4 classification classification NN cord-319448-gt6uqfrl 37 5 of of IN cord-319448-gt6uqfrl 37 6 such such JJ cord-319448-gt6uqfrl 37 7 microorganisms microorganism NNS cord-319448-gt6uqfrl 37 8 as as IN cord-319448-gt6uqfrl 37 9 ' ' `` cord-319448-gt6uqfrl 37 10 opportunistic opportunistic JJ cord-319448-gt6uqfrl 37 11 ' ' '' cord-319448-gt6uqfrl 37 12 was be VBD cord-319448-gt6uqfrl 37 13 often often RB cord-319448-gt6uqfrl 37 14 inadequate inadequate JJ cord-319448-gt6uqfrl 37 15 and and CC cord-319448-gt6uqfrl 37 16 misleading misleading JJ cord-319448-gt6uqfrl 37 17 , , , cord-319448-gt6uqfrl 37 18 as as IN cord-319448-gt6uqfrl 37 19 some some DT cord-319448-gt6uqfrl 37 20 so so RB cord-319448-gt6uqfrl 37 21 - - HYPH cord-319448-gt6uqfrl 37 22 called call VBN cord-319448-gt6uqfrl 37 23 ' ' `` cord-319448-gt6uqfrl 37 24 opportunistic opportunistic JJ cord-319448-gt6uqfrl 37 25 ' ' '' cord-319448-gt6uqfrl 37 26 microorganisms microorganism NNS cord-319448-gt6uqfrl 37 27 can can MD cord-319448-gt6uqfrl 37 28 also also RB cord-319448-gt6uqfrl 37 29 cause cause VB cord-319448-gt6uqfrl 37 30 disease disease NN cord-319448-gt6uqfrl 37 31 in in IN cord-319448-gt6uqfrl 37 32 normal normal JJ cord-319448-gt6uqfrl 37 33 hosts host NNS cord-319448-gt6uqfrl 37 34 15 15 CD cord-319448-gt6uqfrl 37 35 . . . cord-319448-gt6uqfrl 38 1 Host host NN cord-319448-gt6uqfrl 38 2 failure failure NN cord-319448-gt6uqfrl 38 3 , , , cord-319448-gt6uqfrl 38 4 which which WDT cord-319448-gt6uqfrl 38 5 is be VBZ cord-319448-gt6uqfrl 38 6 a a DT cord-319448-gt6uqfrl 38 7 ' ' `` cord-319448-gt6uqfrl 38 8 host host NN cord-319448-gt6uqfrl 38 9 - - HYPH cord-319448-gt6uqfrl 38 10 centred centre VBN cord-319448-gt6uqfrl 38 11 ' ' '' cord-319448-gt6uqfrl 38 12 view view NN cord-319448-gt6uqfrl 38 13 of of IN cord-319448-gt6uqfrl 38 14 microbial microbial JJ cord-319448-gt6uqfrl 38 15 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 38 16 , , , cord-319448-gt6uqfrl 38 17 has have VBZ cord-319448-gt6uqfrl 38 18 also also RB cord-319448-gt6uqfrl 38 19 been be VBN cord-319448-gt6uqfrl 38 20 used use VBN cord-319448-gt6uqfrl 38 21 to to TO cord-319448-gt6uqfrl 38 22 explain explain VB cord-319448-gt6uqfrl 38 23 the the DT cord-319448-gt6uqfrl 38 24 occurrence occurrence NN cord-319448-gt6uqfrl 38 25 of of IN cord-319448-gt6uqfrl 38 26 diseases disease NNS cord-319448-gt6uqfrl 38 27 that that WDT cord-319448-gt6uqfrl 38 28 are be VBP cord-319448-gt6uqfrl 38 29 caused cause VBN cord-319448-gt6uqfrl 38 30 by by IN cord-319448-gt6uqfrl 38 31 microorganisms microorganism NNS cord-319448-gt6uqfrl 38 32 that that WDT cord-319448-gt6uqfrl 38 33 do do VBP cord-319448-gt6uqfrl 38 34 not not RB cord-319448-gt6uqfrl 38 35 fit fit VB cord-319448-gt6uqfrl 38 36 Koch Koch NNP cord-319448-gt6uqfrl 38 37 's 's POS cord-319448-gt6uqfrl 38 38 postulates postulate NNS cord-319448-gt6uqfrl 38 39 because because IN cord-319448-gt6uqfrl 38 40 they -PRON- PRP cord-319448-gt6uqfrl 38 41 lack lack VBP cord-319448-gt6uqfrl 38 42 virulence virulence NN cord-319448-gt6uqfrl 38 43 determinants determinant NNS cord-319448-gt6uqfrl 38 44 . . . cord-319448-gt6uqfrl 39 1 These these DT cord-319448-gt6uqfrl 39 2 microorganisms microorganism NNS cord-319448-gt6uqfrl 39 3 do do VBP cord-319448-gt6uqfrl 39 4 not not RB cord-319448-gt6uqfrl 39 5 cause cause VB cord-319448-gt6uqfrl 39 6 disease disease NN cord-319448-gt6uqfrl 39 7 in in IN cord-319448-gt6uqfrl 39 8 all all DT cord-319448-gt6uqfrl 39 9 hosts host NNS cord-319448-gt6uqfrl 39 10 17 17 CD cord-319448-gt6uqfrl 39 11 and and CC cord-319448-gt6uqfrl 39 12 so so RB cord-319448-gt6uqfrl 39 13 can can MD cord-319448-gt6uqfrl 39 14 not not RB cord-319448-gt6uqfrl 39 15 be be VB cord-319448-gt6uqfrl 39 16 explained explain VBN cord-319448-gt6uqfrl 39 17 by by IN cord-319448-gt6uqfrl 39 18 ' ' `` cord-319448-gt6uqfrl 39 19 microorganism microorganism NN cord-319448-gt6uqfrl 39 20 - - HYPH cord-319448-gt6uqfrl 39 21 centred centre VBN cord-319448-gt6uqfrl 39 22 ' ' '' cord-319448-gt6uqfrl 39 23 views view NNS cord-319448-gt6uqfrl 39 24 . . . cord-319448-gt6uqfrl 40 1 Examples example NNS cord-319448-gt6uqfrl 40 2 of of IN cord-319448-gt6uqfrl 40 3 such such JJ cord-319448-gt6uqfrl 40 4 diseases disease NNS cord-319448-gt6uqfrl 40 5 are be VBP cord-319448-gt6uqfrl 40 6 catheter catheter NN cord-319448-gt6uqfrl 40 7 - - HYPH cord-319448-gt6uqfrl 40 8 associated associate VBN cord-319448-gt6uqfrl 40 9 candidiasis candidiasis NN cord-319448-gt6uqfrl 40 10 , , , cord-319448-gt6uqfrl 40 11 Staphylococcus Staphylococcus NNP cord-319448-gt6uqfrl 40 12 epidermidis epidermidis NN cord-319448-gt6uqfrl 40 13 endocarditis endocarditis NN cord-319448-gt6uqfrl 40 14 and and CC cord-319448-gt6uqfrl 40 15 Pneumocystis Pneumocystis NNP cord-319448-gt6uqfrl 40 16 carinii carinii FW cord-319448-gt6uqfrl 40 17 pneumonia pneumonia NN cord-319448-gt6uqfrl 40 18 . . . cord-319448-gt6uqfrl 41 1 The the DT cord-319448-gt6uqfrl 41 2 study study NN cord-319448-gt6uqfrl 41 3 of of IN cord-319448-gt6uqfrl 41 4 microbial microbial JJ cord-319448-gt6uqfrl 41 5 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 41 6 has have VBZ cord-319448-gt6uqfrl 41 7 its -PRON- PRP$ cord-319448-gt6uqfrl 41 8 intellectual intellectual JJ cord-319448-gt6uqfrl 41 9 and and CC cord-319448-gt6uqfrl 41 10 scientific scientific JJ cord-319448-gt6uqfrl 41 11 origins origin NNS cord-319448-gt6uqfrl 41 12 in in IN cord-319448-gt6uqfrl 41 13 microbiology microbiology NN cord-319448-gt6uqfrl 41 14 and and CC cord-319448-gt6uqfrl 41 15 immunology immunology NN cord-319448-gt6uqfrl 41 16 -two -two : cord-319448-gt6uqfrl 41 17 fields field NNS cord-319448-gt6uqfrl 41 18 that that WDT cord-319448-gt6uqfrl 41 19 are be VBP cord-319448-gt6uqfrl 41 20 largely largely RB cord-319448-gt6uqfrl 41 21 ' ' `` cord-319448-gt6uqfrl 41 22 microorganism microorganism NN cord-319448-gt6uqfrl 41 23 - - HYPH cord-319448-gt6uqfrl 41 24 centred centre VBN cord-319448-gt6uqfrl 41 25 ' ' '' cord-319448-gt6uqfrl 41 26 and and CC cord-319448-gt6uqfrl 41 27 ' ' `` cord-319448-gt6uqfrl 41 28 host host NN cord-319448-gt6uqfrl 41 29 - - HYPH cord-319448-gt6uqfrl 41 30 centred centre VBN cord-319448-gt6uqfrl 41 31 ' ' '' cord-319448-gt6uqfrl 41 32 , , , cord-319448-gt6uqfrl 41 33 respectively respectively RB cord-319448-gt6uqfrl 41 34 . . . cord-319448-gt6uqfrl 42 1 Indeed indeed RB cord-319448-gt6uqfrl 42 2 , , , cord-319448-gt6uqfrl 42 3 an an DT cord-319448-gt6uqfrl 42 4 inherent inherent JJ cord-319448-gt6uqfrl 42 5 bias bias NN cord-319448-gt6uqfrl 42 6 towards towards IN cord-319448-gt6uqfrl 42 7 either either CC cord-319448-gt6uqfrl 42 8 the the DT cord-319448-gt6uqfrl 42 9 host host NN cord-319448-gt6uqfrl 42 10 or or CC cord-319448-gt6uqfrl 42 11 the the DT cord-319448-gt6uqfrl 42 12 microorganism microorganism NN cord-319448-gt6uqfrl 42 13 is be VBZ cord-319448-gt6uqfrl 42 14 often often RB cord-319448-gt6uqfrl 42 15 central central JJ cord-319448-gt6uqfrl 42 16 to to IN cord-319448-gt6uqfrl 42 17 the the DT cord-319448-gt6uqfrl 42 18 thinking thinking NN cord-319448-gt6uqfrl 42 19 and and CC cord-319448-gt6uqfrl 42 20 investigative investigative JJ cord-319448-gt6uqfrl 42 21 approaches approach NNS cord-319448-gt6uqfrl 42 22 of of IN cord-319448-gt6uqfrl 42 23 immunologists immunologist NNS cord-319448-gt6uqfrl 42 24 and and CC cord-319448-gt6uqfrl 42 25 microbiologists microbiologist NNS cord-319448-gt6uqfrl 42 26 , , , cord-319448-gt6uqfrl 42 27 respectively respectively RB cord-319448-gt6uqfrl 42 28 . . . cord-319448-gt6uqfrl 43 1 ' ' `` cord-319448-gt6uqfrl 43 2 Microorganism microorganism NN cord-319448-gt6uqfrl 43 3 - - HYPH cord-319448-gt6uqfrl 43 4 centred centre VBN cord-319448-gt6uqfrl 43 5 ' ' '' cord-319448-gt6uqfrl 43 6 investigators investigator NNS cord-319448-gt6uqfrl 43 7 tend tend VBP cord-319448-gt6uqfrl 43 8 to to TO cord-319448-gt6uqfrl 43 9 test test VB cord-319448-gt6uqfrl 43 10 the the DT cord-319448-gt6uqfrl 43 11 influence influence NN cord-319448-gt6uqfrl 43 12 of of IN cord-319448-gt6uqfrl 43 13 microbial microbial JJ cord-319448-gt6uqfrl 43 14 manipulations manipulation NNS cord-319448-gt6uqfrl 43 15 ( ( -LRB- cord-319448-gt6uqfrl 43 16 mutants mutant NNS cord-319448-gt6uqfrl 43 17 ) ) -RRB- cord-319448-gt6uqfrl 43 18 on on IN cord-319448-gt6uqfrl 43 19 virulence virulence NN cord-319448-gt6uqfrl 43 20 by by IN cord-319448-gt6uqfrl 43 21 holding hold VBG cord-319448-gt6uqfrl 43 22 the the DT cord-319448-gt6uqfrl 43 23 host host NN cord-319448-gt6uqfrl 43 24 variables variable NNS cord-319448-gt6uqfrl 43 25 constant constant JJ cord-319448-gt6uqfrl 43 26 -as -as CD cord-319448-gt6uqfrl 43 27 exemplified exemplify VBN cord-319448-gt6uqfrl 43 28 by by IN cord-319448-gt6uqfrl 43 29 the the DT cord-319448-gt6uqfrl 43 30 frequent frequent JJ cord-319448-gt6uqfrl 43 31 use use NN cord-319448-gt6uqfrl 43 32 of of IN cord-319448-gt6uqfrl 43 33 immunologically immunologically RB cord-319448-gt6uqfrl 43 34 naive naive JJ cord-319448-gt6uqfrl 43 35 and and CC cord-319448-gt6uqfrl 43 36 genetically genetically RB cord-319448-gt6uqfrl 43 37 inbred inbred JJ cord-319448-gt6uqfrl 43 38 hosts host NNS cord-319448-gt6uqfrl 43 39 . . . cord-319448-gt6uqfrl 44 1 The the DT cord-319448-gt6uqfrl 44 2 capacity capacity NN cord-319448-gt6uqfrl 44 3 of of IN cord-319448-gt6uqfrl 44 4 a a DT cord-319448-gt6uqfrl 44 5 defined define VBN cord-319448-gt6uqfrl 44 6 characteristic characteristic NN cord-319448-gt6uqfrl 44 7 , , , cord-319448-gt6uqfrl 44 8 or or CC cord-319448-gt6uqfrl 44 9 mutation mutation NN cord-319448-gt6uqfrl 44 10 , , , cord-319448-gt6uqfrl 44 11 to to TO cord-319448-gt6uqfrl 44 12 confer confer VB cord-319448-gt6uqfrl 44 13 virulence virulence NN cord-319448-gt6uqfrl 44 14 in in IN cord-319448-gt6uqfrl 44 15 a a DT cord-319448-gt6uqfrl 44 16 host host NN cord-319448-gt6uqfrl 44 17 is be VBZ cord-319448-gt6uqfrl 44 18 required require VBN cord-319448-gt6uqfrl 44 19 to to TO cord-319448-gt6uqfrl 44 20 fulfil fulfil VB cord-319448-gt6uqfrl 44 21 molecular molecular JJ cord-319448-gt6uqfrl 44 22 Koch Koch NNP cord-319448-gt6uqfrl 44 23 's 's POS cord-319448-gt6uqfrl 44 24 postulates postulate NNS cord-319448-gt6uqfrl 44 25 14 14 CD cord-319448-gt6uqfrl 44 26 . . . cord-319448-gt6uqfrl 45 1 By by IN cord-319448-gt6uqfrl 45 2 contrast contrast NN cord-319448-gt6uqfrl 45 3 , , , cord-319448-gt6uqfrl 45 4 the the DT cord-319448-gt6uqfrl 45 5 approach approach NN cord-319448-gt6uqfrl 45 6 of of IN cord-319448-gt6uqfrl 45 7 ' ' `` cord-319448-gt6uqfrl 45 8 hostcentred hostcentred JJ cord-319448-gt6uqfrl 45 9 ' ' '' cord-319448-gt6uqfrl 45 10 investigators investigator NNS cord-319448-gt6uqfrl 45 11 , , , cord-319448-gt6uqfrl 45 12 such such JJ cord-319448-gt6uqfrl 45 13 as as IN cord-319448-gt6uqfrl 45 14 immunologists immunologist NNS cord-319448-gt6uqfrl 45 15 , , , cord-319448-gt6uqfrl 45 16 generally generally RB cord-319448-gt6uqfrl 45 17 involves involve VBZ cord-319448-gt6uqfrl 45 18 manipulation manipulation NN cord-319448-gt6uqfrl 45 19 of of IN cord-319448-gt6uqfrl 45 20 the the DT cord-319448-gt6uqfrl 45 21 host host NN cord-319448-gt6uqfrl 45 22 as as IN cord-319448-gt6uqfrl 45 23 the the DT cord-319448-gt6uqfrl 45 24 microbial microbial JJ cord-319448-gt6uqfrl 45 25 variables variable NNS cord-319448-gt6uqfrl 45 26 are be VBP cord-319448-gt6uqfrl 45 27 held hold VBN cord-319448-gt6uqfrl 45 28 constant constant JJ cord-319448-gt6uqfrl 45 29 . . . cord-319448-gt6uqfrl 46 1 This this DT cord-319448-gt6uqfrl 46 2 is be VBZ cord-319448-gt6uqfrl 46 3 exemplified exemplify VBN cord-319448-gt6uqfrl 46 4 by by IN cord-319448-gt6uqfrl 46 5 studies study NNS cord-319448-gt6uqfrl 46 6 that that WDT cord-319448-gt6uqfrl 46 7 attempt attempt VBP cord-319448-gt6uqfrl 46 8 to to TO cord-319448-gt6uqfrl 46 9 establish establish VB cord-319448-gt6uqfrl 46 10 that that IN cord-319448-gt6uqfrl 46 11 a a DT cord-319448-gt6uqfrl 46 12 host host NN cord-319448-gt6uqfrl 46 13 component component NN cord-319448-gt6uqfrl 46 14 is be VBZ cord-319448-gt6uqfrl 46 15 essential essential JJ cord-319448-gt6uqfrl 46 16 for for IN cord-319448-gt6uqfrl 46 17 host host NN cord-319448-gt6uqfrl 46 18 defence defence NN cord-319448-gt6uqfrl 46 19 by by IN cord-319448-gt6uqfrl 46 20 comparing compare VBG cord-319448-gt6uqfrl 46 21 the the DT cord-319448-gt6uqfrl 46 22 outcome outcome NN cord-319448-gt6uqfrl 46 23 of of IN cord-319448-gt6uqfrl 46 24 infection infection NN cord-319448-gt6uqfrl 46 25 with with IN cord-319448-gt6uqfrl 46 26 the the DT cord-319448-gt6uqfrl 46 27 relevant relevant JJ cord-319448-gt6uqfrl 46 28 microorganism microorganism NN cord-319448-gt6uqfrl 46 29 in in IN cord-319448-gt6uqfrl 46 30 both both CC cord-319448-gt6uqfrl 46 31 normal normal JJ cord-319448-gt6uqfrl 46 32 ( ( -LRB- cord-319448-gt6uqfrl 46 33 wild wild JJ cord-319448-gt6uqfrl 46 34 - - HYPH cord-319448-gt6uqfrl 46 35 type type NN cord-319448-gt6uqfrl 46 36 ) ) -RRB- cord-319448-gt6uqfrl 46 37 and and CC cord-319448-gt6uqfrl 46 38 deficient deficient JJ cord-319448-gt6uqfrl 46 39 ( ( -LRB- cord-319448-gt6uqfrl 46 40 knockout knockout NN cord-319448-gt6uqfrl 46 41 ) ) -RRB- cord-319448-gt6uqfrl 46 42 mice mouse NNS cord-319448-gt6uqfrl 46 43 . . . cord-319448-gt6uqfrl 47 1 Notably notably RB cord-319448-gt6uqfrl 47 2 , , , cord-319448-gt6uqfrl 47 3 the the DT cord-319448-gt6uqfrl 47 4 field field NN cord-319448-gt6uqfrl 47 5 of of IN cord-319448-gt6uqfrl 47 6 vaccinology vaccinology NN cord-319448-gt6uqfrl 47 7 has have VBZ cord-319448-gt6uqfrl 47 8 elements element NNS cord-319448-gt6uqfrl 47 9 of of IN cord-319448-gt6uqfrl 47 10 both both DT cord-319448-gt6uqfrl 47 11 views view NNS cord-319448-gt6uqfrl 47 12 , , , cord-319448-gt6uqfrl 47 13 as as IN cord-319448-gt6uqfrl 47 14 evidenced evidence VBN cord-319448-gt6uqfrl 47 15 by by IN cord-319448-gt6uqfrl 47 16 ' ' `` cord-319448-gt6uqfrl 47 17 microorganism microorganism NN cord-319448-gt6uqfrl 47 18 - - HYPH cord-319448-gt6uqfrl 47 19 centred centre VBN cord-319448-gt6uqfrl 47 20 ' ' '' cord-319448-gt6uqfrl 47 21 approaches approach NNS cord-319448-gt6uqfrl 47 22 with with IN cord-319448-gt6uqfrl 47 23 ' ' `` cord-319448-gt6uqfrl 47 24 host host NN cord-319448-gt6uqfrl 47 25 - - HYPH cord-319448-gt6uqfrl 47 26 centred centre VBN cord-319448-gt6uqfrl 47 27 ' ' '' cord-319448-gt6uqfrl 47 28 thinking thinking NN cord-319448-gt6uqfrl 47 29 -a -a HYPH cord-319448-gt6uqfrl 47 30 distinction distinction NN cord-319448-gt6uqfrl 47 31 that that WDT cord-319448-gt6uqfrl 47 32 can can MD cord-319448-gt6uqfrl 47 33 place place VB cord-319448-gt6uqfrl 47 34 it -PRON- PRP cord-319448-gt6uqfrl 47 35 at at IN cord-319448-gt6uqfrl 47 36 odds odd NNS cord-319448-gt6uqfrl 47 37 with with IN cord-319448-gt6uqfrl 47 38 its -PRON- PRP$ cord-319448-gt6uqfrl 47 39 parental parental JJ cord-319448-gt6uqfrl 47 40 discipline discipline NN cord-319448-gt6uqfrl 47 41 of of IN cord-319448-gt6uqfrl 47 42 immunology immunology NN cord-319448-gt6uqfrl 47 43 18 18 CD cord-319448-gt6uqfrl 47 44 . . . cord-319448-gt6uqfrl 48 1 Although although IN cord-319448-gt6uqfrl 48 2 ' ' `` cord-319448-gt6uqfrl 48 3 microorganism microorganism NN cord-319448-gt6uqfrl 48 4 - - HYPH cord-319448-gt6uqfrl 48 5 centred centre VBN cord-319448-gt6uqfrl 48 6 ' ' '' cord-319448-gt6uqfrl 48 7 and and CC cord-319448-gt6uqfrl 48 8 ' ' `` cord-319448-gt6uqfrl 48 9 hostcentred hostcentre VBD cord-319448-gt6uqfrl 48 10 ' ' '' cord-319448-gt6uqfrl 48 11 views view NNS cord-319448-gt6uqfrl 48 12 of of IN cord-319448-gt6uqfrl 48 13 microbial microbial JJ cord-319448-gt6uqfrl 48 14 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 48 15 have have VBP cord-319448-gt6uqfrl 48 16 each each DT cord-319448-gt6uqfrl 48 17 provided provide VBN cord-319448-gt6uqfrl 48 18 valuable valuable JJ cord-319448-gt6uqfrl 48 19 insights insight NNS cord-319448-gt6uqfrl 48 20 into into IN cord-319448-gt6uqfrl 48 21 microbial microbial JJ cord-319448-gt6uqfrl 48 22 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 48 23 , , , cord-319448-gt6uqfrl 48 24 neither neither CC cord-319448-gt6uqfrl 48 25 simulates simulate VBZ cord-319448-gt6uqfrl 48 26 the the DT cord-319448-gt6uqfrl 48 27 reality reality NN cord-319448-gt6uqfrl 48 28 in in IN cord-319448-gt6uqfrl 48 29 which which WDT cord-319448-gt6uqfrl 48 30 each each DT cord-319448-gt6uqfrl 48 31 hostmicroorganism hostmicroorganism NN cord-319448-gt6uqfrl 48 32 interaction interaction NN cord-319448-gt6uqfrl 48 33 is be VBZ cord-319448-gt6uqfrl 48 34 unique unique JJ cord-319448-gt6uqfrl 48 35 and and CC cord-319448-gt6uqfrl 48 36 occurs occur VBZ cord-319448-gt6uqfrl 48 37 against against IN cord-319448-gt6uqfrl 48 38 a a DT cord-319448-gt6uqfrl 48 39 background background NN cord-319448-gt6uqfrl 48 40 of of IN cord-319448-gt6uqfrl 48 41 constant constant JJ cord-319448-gt6uqfrl 48 42 changes change NNS cord-319448-gt6uqfrl 48 43 in in IN cord-319448-gt6uqfrl 48 44 both both DT cord-319448-gt6uqfrl 48 45 immune immune JJ cord-319448-gt6uqfrl 48 46 function function NN cord-319448-gt6uqfrl 48 47 and and CC cord-319448-gt6uqfrl 48 48 microbial microbial JJ cord-319448-gt6uqfrl 48 49 fitness fitness NN cord-319448-gt6uqfrl 48 50 . . . cord-319448-gt6uqfrl 49 1 It -PRON- PRP cord-319448-gt6uqfrl 49 2 might may MD cord-319448-gt6uqfrl 49 3 not not RB cord-319448-gt6uqfrl 49 4 always always RB cord-319448-gt6uqfrl 49 5 be be VB cord-319448-gt6uqfrl 49 6 possible possible JJ cord-319448-gt6uqfrl 49 7 to to TO cord-319448-gt6uqfrl 49 8 account account VB cord-319448-gt6uqfrl 49 9 for for IN cord-319448-gt6uqfrl 49 10 both both DT cord-319448-gt6uqfrl 49 11 ' ' `` cord-319448-gt6uqfrl 49 12 microorganism microorganism NN cord-319448-gt6uqfrl 49 13 - - HYPH cord-319448-gt6uqfrl 49 14 centred centre VBN cord-319448-gt6uqfrl 49 15 ' ' '' cord-319448-gt6uqfrl 49 16 and and CC cord-319448-gt6uqfrl 49 17 ' ' `` cord-319448-gt6uqfrl 49 18 host host NN cord-319448-gt6uqfrl 49 19 - - HYPH cord-319448-gt6uqfrl 49 20 centred centre VBN cord-319448-gt6uqfrl 49 21 ' ' '' cord-319448-gt6uqfrl 49 22 views view NNS cord-319448-gt6uqfrl 49 23 in in IN cord-319448-gt6uqfrl 49 24 experimental experimental JJ cord-319448-gt6uqfrl 49 25 design design NN cord-319448-gt6uqfrl 49 26 . . . cord-319448-gt6uqfrl 50 1 However however RB cord-319448-gt6uqfrl 50 2 , , , cord-319448-gt6uqfrl 50 3 consideration consideration NN cord-319448-gt6uqfrl 50 4 of of IN cord-319448-gt6uqfrl 50 5 the the DT cord-319448-gt6uqfrl 50 6 possible possible JJ cord-319448-gt6uqfrl 50 7 contributions contribution NNS cord-319448-gt6uqfrl 50 8 of of IN cord-319448-gt6uqfrl 50 9 both both CC cord-319448-gt6uqfrl 50 10 the the DT cord-319448-gt6uqfrl 50 11 host host NN cord-319448-gt6uqfrl 50 12 and and CC cord-319448-gt6uqfrl 50 13 the the DT cord-319448-gt6uqfrl 50 14 microorganism microorganism NN cord-319448-gt6uqfrl 50 15 to to TO cord-319448-gt6uqfrl 50 16 host host VB cord-319448-gt6uqfrl 50 17 damage damage NN cord-319448-gt6uqfrl 50 18 could could MD cord-319448-gt6uqfrl 50 19 focus focus VB cord-319448-gt6uqfrl 50 20 studies study NNS cord-319448-gt6uqfrl 50 21 of of IN cord-319448-gt6uqfrl 50 22 microbial microbial JJ cord-319448-gt6uqfrl 50 23 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 50 24 around around IN cord-319448-gt6uqfrl 50 25 a a DT cord-319448-gt6uqfrl 50 26 common common JJ cord-319448-gt6uqfrl 50 27 principle principle NN cord-319448-gt6uqfrl 50 28 , , , cord-319448-gt6uqfrl 50 29 and and CC cord-319448-gt6uqfrl 50 30 has have VBZ cord-319448-gt6uqfrl 50 31 the the DT cord-319448-gt6uqfrl 50 32 potential potential NN cord-319448-gt6uqfrl 50 33 to to TO cord-319448-gt6uqfrl 50 34 unify unify VB cord-319448-gt6uqfrl 50 35 the the DT cord-319448-gt6uqfrl 50 36 field field NN cord-319448-gt6uqfrl 50 37 of of IN cord-319448-gt6uqfrl 50 38 microbial microbial JJ cord-319448-gt6uqfrl 50 39 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 50 40 and and CC cord-319448-gt6uqfrl 50 41 the the DT cord-319448-gt6uqfrl 50 42 allied ally VBN cord-319448-gt6uqfrl 50 43 disciplines discipline NNS cord-319448-gt6uqfrl 50 44 of of IN cord-319448-gt6uqfrl 50 45 immunology immunology NN cord-319448-gt6uqfrl 50 46 and and CC cord-319448-gt6uqfrl 50 47 vaccinology vaccinology NN cord-319448-gt6uqfrl 50 48 . . . cord-319448-gt6uqfrl 51 1 to to IN cord-319448-gt6uqfrl 51 2 the the DT cord-319448-gt6uqfrl 51 3 ingested ingest VBN cord-319448-gt6uqfrl 51 4 microorganism microorganism NN cord-319448-gt6uqfrl 51 5 . . . cord-319448-gt6uqfrl 52 1 However however RB cord-319448-gt6uqfrl 52 2 , , , cord-319448-gt6uqfrl 52 3 the the DT cord-319448-gt6uqfrl 52 4 ingestion ingestion NN cord-319448-gt6uqfrl 52 5 of of IN cord-319448-gt6uqfrl 52 6 certain certain JJ cord-319448-gt6uqfrl 52 7 microorganisms microorganism NNS cord-319448-gt6uqfrl 52 8 , , , cord-319448-gt6uqfrl 52 9 such such JJ cord-319448-gt6uqfrl 52 10 as as IN cord-319448-gt6uqfrl 52 11 Legionella Legionella NNP cord-319448-gt6uqfrl 52 12 pneumophila pneumophila NN cord-319448-gt6uqfrl 52 13 or or CC cord-319448-gt6uqfrl 52 14 Cryptococcus Cryptococcus NNP cord-319448-gt6uqfrl 52 15 neoformans neoforman NNS cord-319448-gt6uqfrl 52 16 , , , cord-319448-gt6uqfrl 52 17 by by IN cord-319448-gt6uqfrl 52 18 the the DT cord-319448-gt6uqfrl 52 19 amoeba amoeba NNP cord-319448-gt6uqfrl 52 20 Acanthamoebae Acanthamoebae NNP cord-319448-gt6uqfrl 52 21 castellanii castellanii NNP cord-319448-gt6uqfrl 52 22 can can MD cord-319448-gt6uqfrl 52 23 result result VB cord-319448-gt6uqfrl 52 24 in in IN cord-319448-gt6uqfrl 52 25 death death NN cord-319448-gt6uqfrl 52 26 of of IN cord-319448-gt6uqfrl 52 27 the the DT cord-319448-gt6uqfrl 52 28 host host NN cord-319448-gt6uqfrl 52 29 -a -a NN cord-319448-gt6uqfrl 52 30 process process NN cord-319448-gt6uqfrl 52 31 with with IN cord-319448-gt6uqfrl 52 32 striking strike VBG cord-319448-gt6uqfrl 52 33 similarities similarity NNS cord-319448-gt6uqfrl 52 34 to to IN cord-319448-gt6uqfrl 52 35 the the DT cord-319448-gt6uqfrl 52 36 interaction interaction NN cord-319448-gt6uqfrl 52 37 of of IN cord-319448-gt6uqfrl 52 38 these these DT cord-319448-gt6uqfrl 52 39 microorganisms microorganism NNS cord-319448-gt6uqfrl 52 40 with with IN cord-319448-gt6uqfrl 52 41 macrophages macrophage NNS cord-319448-gt6uqfrl 52 42 in in IN cord-319448-gt6uqfrl 52 43 mammalian mammalian JJ cord-319448-gt6uqfrl 52 44 hosts host NNS cord-319448-gt6uqfrl 52 45 10 10 CD cord-319448-gt6uqfrl 52 46 , , , cord-319448-gt6uqfrl 52 47 11 11 CD cord-319448-gt6uqfrl 52 48 . . . cord-319448-gt6uqfrl 53 1 The the DT cord-319448-gt6uqfrl 53 2 same same JJ cord-319448-gt6uqfrl 53 3 amoebae amoebae NN cord-319448-gt6uqfrl 53 4 , , , cord-319448-gt6uqfrl 53 5 however however RB cord-319448-gt6uqfrl 53 6 , , , cord-319448-gt6uqfrl 53 7 can can MD cord-319448-gt6uqfrl 53 8 be be VB cord-319448-gt6uqfrl 53 9 microorganisms microorganism NNS cord-319448-gt6uqfrl 53 10 in in IN cord-319448-gt6uqfrl 53 11 human human JJ cord-319448-gt6uqfrl 53 12 hosts host NNS cord-319448-gt6uqfrl 53 13 and and CC cord-319448-gt6uqfrl 53 14 cause cause VB cord-319448-gt6uqfrl 53 15 amoebic amoebic JJ cord-319448-gt6uqfrl 53 16 keratitis keratitis NN cord-319448-gt6uqfrl 53 17 . . . cord-319448-gt6uqfrl 54 1 Therefore therefore RB cord-319448-gt6uqfrl 54 2 , , , cord-319448-gt6uqfrl 54 3 the the DT cord-319448-gt6uqfrl 54 4 distinction distinction NN cord-319448-gt6uqfrl 54 5 between between IN cord-319448-gt6uqfrl 54 6 host host NN cord-319448-gt6uqfrl 54 7 and and CC cord-319448-gt6uqfrl 54 8 microorganism microorganism NN cord-319448-gt6uqfrl 54 9 is be VBZ cord-319448-gt6uqfrl 54 10 not not RB cord-319448-gt6uqfrl 54 11 invariant invariant JJ cord-319448-gt6uqfrl 54 12 , , , cord-319448-gt6uqfrl 54 13 yet yet CC cord-319448-gt6uqfrl 54 14 it -PRON- PRP cord-319448-gt6uqfrl 54 15 is be VBZ cord-319448-gt6uqfrl 54 16 relevant relevant JJ cord-319448-gt6uqfrl 54 17 to to IN cord-319448-gt6uqfrl 54 18 understanding understand VBG cord-319448-gt6uqfrl 54 19 the the DT cord-319448-gt6uqfrl 54 20 outcome outcome NN cord-319448-gt6uqfrl 54 21 of of IN cord-319448-gt6uqfrl 54 22 certain certain JJ cord-319448-gt6uqfrl 54 23 host host NN cord-319448-gt6uqfrl 54 24 - - HYPH cord-319448-gt6uqfrl 54 25 microorganism microorganism NN cord-319448-gt6uqfrl 54 26 interactions interaction NNS cord-319448-gt6uqfrl 54 27 . . . cord-319448-gt6uqfrl 55 1 Despite despite IN cord-319448-gt6uqfrl 55 2 being be VBG cord-319448-gt6uqfrl 55 3 the the DT cord-319448-gt6uqfrl 55 4 outcome outcome NN cord-319448-gt6uqfrl 55 5 of of IN cord-319448-gt6uqfrl 55 6 an an DT cord-319448-gt6uqfrl 55 7 interaction interaction NN cord-319448-gt6uqfrl 55 8 , , , cord-319448-gt6uqfrl 55 9 microbial microbial JJ cord-319448-gt6uqfrl 55 10 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 55 11 is be VBZ cord-319448-gt6uqfrl 55 12 often often RB cord-319448-gt6uqfrl 55 13 viewed view VBN cord-319448-gt6uqfrl 55 14 as as IN cord-319448-gt6uqfrl 55 15 a a DT cord-319448-gt6uqfrl 55 16 ' ' `` cord-319448-gt6uqfrl 55 17 microorganismcentred microorganismcentred JJ cord-319448-gt6uqfrl 55 18 ' ' '' cord-319448-gt6uqfrl 55 19 process process NN cord-319448-gt6uqfrl 55 20 . . . cord-319448-gt6uqfrl 56 1 There there EX cord-319448-gt6uqfrl 56 2 are be VBP cord-319448-gt6uqfrl 56 3 also also RB cord-319448-gt6uqfrl 56 4 proponents proponent NNS cord-319448-gt6uqfrl 56 5 of of IN cord-319448-gt6uqfrl 56 6 the the DT cord-319448-gt6uqfrl 56 7 view view NN cord-319448-gt6uqfrl 56 8 that that IN cord-319448-gt6uqfrl 56 9 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 56 10 is be VBZ cord-319448-gt6uqfrl 56 11 ' ' `` cord-319448-gt6uqfrl 56 12 host host NN cord-319448-gt6uqfrl 56 13 - - HYPH cord-319448-gt6uqfrl 56 14 centred centre VBN cord-319448-gt6uqfrl 56 15 ' ' '' cord-319448-gt6uqfrl 56 16 . . . cord-319448-gt6uqfrl 57 1 Although although IN cord-319448-gt6uqfrl 57 2 ' ' `` cord-319448-gt6uqfrl 57 3 microorganism microorganism NN cord-319448-gt6uqfrl 57 4 - - HYPH cord-319448-gt6uqfrl 57 5 centred centre VBN cord-319448-gt6uqfrl 57 6 ' ' '' cord-319448-gt6uqfrl 57 7 advocates advocate NNS cord-319448-gt6uqfrl 57 8 recognize recognize VBP cord-319448-gt6uqfrl 57 9 the the DT cord-319448-gt6uqfrl 57 10 importance importance NN cord-319448-gt6uqfrl 57 11 of of IN cord-319448-gt6uqfrl 57 12 the the DT cord-319448-gt6uqfrl 57 13 host host NN cord-319448-gt6uqfrl 57 14 , , , cord-319448-gt6uqfrl 57 15 they -PRON- PRP cord-319448-gt6uqfrl 57 16 generally generally RB cord-319448-gt6uqfrl 57 17 attribute attribute VBP cord-319448-gt6uqfrl 57 18 the the DT cord-319448-gt6uqfrl 57 19 capacity capacity NN cord-319448-gt6uqfrl 57 20 for for IN cord-319448-gt6uqfrl 57 21 pathogenicity pathogenicity NN cord-319448-gt6uqfrl 57 22 and and CC cord-319448-gt6uqfrl 57 23 VIRULENCE virulence NN cord-319448-gt6uqfrl 57 24 to to IN cord-319448-gt6uqfrl 57 25 the the DT cord-319448-gt6uqfrl 57 26 activity activity NN cord-319448-gt6uqfrl 57 27 and and CC cord-319448-gt6uqfrl 57 28 functions function NNS cord-319448-gt6uqfrl 57 29 of of IN cord-319448-gt6uqfrl 57 30 microbial microbial JJ cord-319448-gt6uqfrl 57 31 gene gene NN cord-319448-gt6uqfrl 57 32 products product NNS cord-319448-gt6uqfrl 57 33 and/or and/or CC cord-319448-gt6uqfrl 57 34 microbial microbial JJ cord-319448-gt6uqfrl 57 35 replication replication NN cord-319448-gt6uqfrl 57 36 . . . cord-319448-gt6uqfrl 58 1 Inherent inherent JJ cord-319448-gt6uqfrl 58 2 in in IN cord-319448-gt6uqfrl 58 3 this this DT cord-319448-gt6uqfrl 58 4 view view NN cord-319448-gt6uqfrl 58 5 , , , cord-319448-gt6uqfrl 58 6 is be VBZ cord-319448-gt6uqfrl 58 7 the the DT cord-319448-gt6uqfrl 58 8 belief belief NN cord-319448-gt6uqfrl 58 9 that that IN cord-319448-gt6uqfrl 58 10 microorganisms microorganism NNS cord-319448-gt6uqfrl 58 11 possess possess VBP cord-319448-gt6uqfrl 58 12 certain certain JJ cord-319448-gt6uqfrl 58 13 attributes attribute NNS cord-319448-gt6uqfrl 58 14 that that WDT cord-319448-gt6uqfrl 58 15 make make VBP cord-319448-gt6uqfrl 58 16 them -PRON- PRP cord-319448-gt6uqfrl 58 17 pathogenic pathogenic JJ cord-319448-gt6uqfrl 58 18 , , , cord-319448-gt6uqfrl 58 19 and and CC cord-319448-gt6uqfrl 58 20 that that IN cord-319448-gt6uqfrl 58 21 microorganisms microorganism NNS cord-319448-gt6uqfrl 58 22 that that WDT cord-319448-gt6uqfrl 58 23 do do VBP cord-319448-gt6uqfrl 58 24 not not RB cord-319448-gt6uqfrl 58 25 possess possess VB cord-319448-gt6uqfrl 58 26 these these DT cord-319448-gt6uqfrl 58 27 attributes attribute NNS cord-319448-gt6uqfrl 58 28 are be VBP cord-319448-gt6uqfrl 58 29 not not RB cord-319448-gt6uqfrl 58 30 pathogenic pathogenic JJ cord-319448-gt6uqfrl 58 31 ( ( -LRB- cord-319448-gt6uqfrl 58 32 non non NNS cord-319448-gt6uqfrl 58 33 - - NNS cord-319448-gt6uqfrl 58 34 pathogens pathogen NNS cord-319448-gt6uqfrl 58 35 ) ) -RRB- cord-319448-gt6uqfrl 58 36 . . . cord-319448-gt6uqfrl 58 37 ' ' '' cord-319448-gt6uqfrl 59 1 Microorganism microorganism NN cord-319448-gt6uqfrl 59 2 - - HYPH cord-319448-gt6uqfrl 59 3 centred centre VBN cord-319448-gt6uqfrl 59 4 ' ' '' cord-319448-gt6uqfrl 59 5 views view NNS cord-319448-gt6uqfrl 59 6 have have VBP cord-319448-gt6uqfrl 59 7 their -PRON- PRP$ cord-319448-gt6uqfrl 59 8 intellectual intellectual JJ cord-319448-gt6uqfrl 59 9 origin origin NN cord-319448-gt6uqfrl 59 10 in in IN cord-319448-gt6uqfrl 59 11 the the DT cord-319448-gt6uqfrl 59 12 discovery discovery NN cord-319448-gt6uqfrl 59 13 of of IN cord-319448-gt6uqfrl 59 14 virulins virulin NNS cord-319448-gt6uqfrl 59 15 at at IN cord-319448-gt6uqfrl 59 16 the the DT cord-319448-gt6uqfrl 59 17 turn turn NN cord-319448-gt6uqfrl 59 18 of of IN cord-319448-gt6uqfrl 59 19 the the DT cord-319448-gt6uqfrl 59 20 twentieth twentieth JJ cord-319448-gt6uqfrl 59 21 century century NN cord-319448-gt6uqfrl 59 22 1 1 CD cord-319448-gt6uqfrl 59 23 , , , cord-319448-gt6uqfrl 59 24 are be VBP cord-319448-gt6uqfrl 59 25 strongly strongly RB cord-319448-gt6uqfrl 59 26 supported support VBN cord-319448-gt6uqfrl 59 27 by by IN cord-319448-gt6uqfrl 59 28 the the DT cord-319448-gt6uqfrl 59 29 discovery discovery NN cord-319448-gt6uqfrl 59 30 of of IN cord-319448-gt6uqfrl 59 31 virulence virulence NN cord-319448-gt6uqfrl 59 32 genes gene NNS cord-319448-gt6uqfrl 59 33 and and CC cord-319448-gt6uqfrl 59 34 pathogenicity pathogenicity NN cord-319448-gt6uqfrl 59 35 islands island NNS cord-319448-gt6uqfrl 59 36 , , , cord-319448-gt6uqfrl 59 37 and and CC cord-319448-gt6uqfrl 59 38 are be VBP cord-319448-gt6uqfrl 59 39 common common JJ cord-319448-gt6uqfrl 59 40 in in IN cord-319448-gt6uqfrl 59 41 the the DT cord-319448-gt6uqfrl 59 42 field field NN cord-319448-gt6uqfrl 59 43 of of IN cord-319448-gt6uqfrl 59 44 bacterial bacterial JJ cord-319448-gt6uqfrl 59 45 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 59 46 12 12 CD cord-319448-gt6uqfrl 59 47 , , , cord-319448-gt6uqfrl 59 48 13 13 CD cord-319448-gt6uqfrl 59 49 . . . cord-319448-gt6uqfrl 60 1 The the DT cord-319448-gt6uqfrl 60 2 existence existence NN cord-319448-gt6uqfrl 60 3 of of IN cord-319448-gt6uqfrl 60 4 microbial microbial JJ cord-319448-gt6uqfrl 60 5 factors factor NNS cord-319448-gt6uqfrl 60 6 that that WDT cord-319448-gt6uqfrl 60 7 confer confer VBP cord-319448-gt6uqfrl 60 8 virulence virulence NN cord-319448-gt6uqfrl 60 9 , , , cord-319448-gt6uqfrl 60 10 such such JJ cord-319448-gt6uqfrl 60 11 as as IN cord-319448-gt6uqfrl 60 12 capsular capsular JJ cord-319448-gt6uqfrl 60 13 polysaccharide polysaccharide NN cord-319448-gt6uqfrl 60 14 or or CC cord-319448-gt6uqfrl 60 15 toxins toxin NNS cord-319448-gt6uqfrl 60 16 , , , cord-319448-gt6uqfrl 60 17 gives give VBZ cord-319448-gt6uqfrl 60 18 credence credence NN cord-319448-gt6uqfrl 60 19 to to IN cord-319448-gt6uqfrl 60 20 the the DT cord-319448-gt6uqfrl 60 21 concept concept NN cord-319448-gt6uqfrl 60 22 that that IN cord-319448-gt6uqfrl 60 23 individual individual JJ cord-319448-gt6uqfrl 60 24 gene gene NN cord-319448-gt6uqfrl 60 25 products product NNS cord-319448-gt6uqfrl 60 26 can can MD cord-319448-gt6uqfrl 60 27 determine determine VB cord-319448-gt6uqfrl 60 28 pathogenicity pathogenicity NN cord-319448-gt6uqfrl 60 29 . . . cord-319448-gt6uqfrl 61 1 Such such JJ cord-319448-gt6uqfrl 61 2 microbial microbial JJ cord-319448-gt6uqfrl 61 3 determinants determinant NNS cord-319448-gt6uqfrl 61 4 validate validate VBP cord-319448-gt6uqfrl 61 5 molecular molecular JJ cord-319448-gt6uqfrl 61 6 Koch Koch NNP cord-319448-gt6uqfrl 61 7 's 's POS cord-319448-gt6uqfrl 61 8 postulates postulate NNS cord-319448-gt6uqfrl 61 9 14 14 CD cord-319448-gt6uqfrl 61 10 _SP cord-319448-gt6uqfrl 61 11 . . . cord-319448-gt6uqfrl 62 1 However however RB cord-319448-gt6uqfrl 62 2 , , , cord-319448-gt6uqfrl 62 3 ' ' `` cord-319448-gt6uqfrl 62 4 microorganism microorganism NN cord-319448-gt6uqfrl 62 5 - - HYPH cord-319448-gt6uqfrl 62 6 centred centre VBN cord-319448-gt6uqfrl 62 7 ' ' '' cord-319448-gt6uqfrl 62 8 views view NNS cord-319448-gt6uqfrl 62 9 fail fail VBP cord-319448-gt6uqfrl 62 10 to to TO cord-319448-gt6uqfrl 62 11 account account VB cord-319448-gt6uqfrl 62 12 for for IN cord-319448-gt6uqfrl 62 13 the the DT cord-319448-gt6uqfrl 62 14 pathogenicity pathogenicity NN cord-319448-gt6uqfrl 62 15 of of IN cord-319448-gt6uqfrl 62 16 common common JJ cord-319448-gt6uqfrl 62 17 microorganisms microorganism NNS cord-319448-gt6uqfrl 62 18 , , , cord-319448-gt6uqfrl 62 19 such such JJ cord-319448-gt6uqfrl 62 20 as as IN cord-319448-gt6uqfrl 62 21 Candida Candida NNP cord-319448-gt6uqfrl 62 22 albicans albican NNS cord-319448-gt6uqfrl 62 23 and and CC cord-319448-gt6uqfrl 62 24 Staphylococcus Staphylococcus NNP cord-319448-gt6uqfrl 62 25 aureus aureus NN cord-319448-gt6uqfrl 62 26 , , , cord-319448-gt6uqfrl 62 27 as as IN cord-319448-gt6uqfrl 62 28 the the DT cord-319448-gt6uqfrl 62 29 strains strain NNS cord-319448-gt6uqfrl 62 30 of of IN cord-319448-gt6uqfrl 62 31 these these DT cord-319448-gt6uqfrl 62 32 microorganisms microorganism NNS cord-319448-gt6uqfrl 62 33 that that WDT cord-319448-gt6uqfrl 62 34 are be VBP cord-319448-gt6uqfrl 62 35 isolated isolate VBN cord-319448-gt6uqfrl 62 36 from from IN cord-319448-gt6uqfrl 62 37 symptomatic symptomatic JJ cord-319448-gt6uqfrl 62 38 or or CC cord-319448-gt6uqfrl 62 39 asymptomatic asymptomatic JJ cord-319448-gt6uqfrl 62 40 individuals individual NNS cord-319448-gt6uqfrl 62 41 are be VBP cord-319448-gt6uqfrl 62 42 often often RB cord-319448-gt6uqfrl 62 43 indistinguishable indistinguishable JJ cord-319448-gt6uqfrl 62 44 . . . cord-319448-gt6uqfrl 62 45 ' ' '' cord-319448-gt6uqfrl 63 1 Host host NN cord-319448-gt6uqfrl 63 2 - - HYPH cord-319448-gt6uqfrl 63 3 centred centre VBN cord-319448-gt6uqfrl 63 4 ' ' '' cord-319448-gt6uqfrl 63 5 views view NNS cord-319448-gt6uqfrl 63 6 of of IN cord-319448-gt6uqfrl 63 7 microbial microbial JJ cord-319448-gt6uqfrl 63 8 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 63 9 subscribe subscribe VBP cord-319448-gt6uqfrl 63 10 to to IN cord-319448-gt6uqfrl 63 11 the the DT cord-319448-gt6uqfrl 63 12 concept concept NN cord-319448-gt6uqfrl 63 13 that that IN cord-319448-gt6uqfrl 63 14 a a DT cord-319448-gt6uqfrl 63 15 failure failure NN cord-319448-gt6uqfrl 63 16 of of IN cord-319448-gt6uqfrl 63 17 host host NN cord-319448-gt6uqfrl 63 18 defence defence NN cord-319448-gt6uqfrl 63 19 mechanisms mechanism NNS cord-319448-gt6uqfrl 63 20 results result NNS cord-319448-gt6uqfrl 63 21 in in IN cord-319448-gt6uqfrl 63 22 susceptibility susceptibility NN cord-319448-gt6uqfrl 63 23 to to IN cord-319448-gt6uqfrl 63 24 certain certain JJ cord-319448-gt6uqfrl 63 25 microorganisms microorganism NNS cord-319448-gt6uqfrl 63 26 and and CC cord-319448-gt6uqfrl 63 27 their -PRON- PRP$ cord-319448-gt6uqfrl 63 28 ability ability NN cord-319448-gt6uqfrl 63 29 to to TO cord-319448-gt6uqfrl 63 30 establish establish VB cord-319448-gt6uqfrl 63 31 themselves -PRON- PRP cord-319448-gt6uqfrl 63 32 in in IN cord-319448-gt6uqfrl 63 33 protected protect VBN cord-319448-gt6uqfrl 63 34 niches niche NNS cord-319448-gt6uqfrl 63 35 . . . cord-319448-gt6uqfrl 64 1 ' ' `` cord-319448-gt6uqfrl 64 2 Host host NN cord-319448-gt6uqfrl 64 3 - - HYPH cord-319448-gt6uqfrl 64 4 centred centre VBN cord-319448-gt6uqfrl 64 5 ' ' '' cord-319448-gt6uqfrl 64 6 views view NNS cord-319448-gt6uqfrl 64 7 are be VBP cord-319448-gt6uqfrl 64 8 based base VBN cord-319448-gt6uqfrl 64 9 on on IN cord-319448-gt6uqfrl 64 10 the the DT cord-319448-gt6uqfrl 64 11 fact fact NN cord-319448-gt6uqfrl 64 12 that that IN cord-319448-gt6uqfrl 64 13 not not RB cord-319448-gt6uqfrl 64 14 all all DT cord-319448-gt6uqfrl 64 15 individuals individual NNS cord-319448-gt6uqfrl 64 16 in in IN cord-319448-gt6uqfrl 64 17 a a DT cord-319448-gt6uqfrl 64 18 population population NN cord-319448-gt6uqfrl 64 19 become become VBP cord-319448-gt6uqfrl 64 20 ill ill JJ cord-319448-gt6uqfrl 64 21 after after IN cord-319448-gt6uqfrl 64 22 infection infection NN cord-319448-gt6uqfrl 64 23 with with IN cord-319448-gt6uqfrl 64 24 a a DT cord-319448-gt6uqfrl 64 25 PATHOGENIC pathogenic JJ cord-319448-gt6uqfrl 64 26 MICROORGANISM microorganism NN cord-319448-gt6uqfrl 64 27 . . . cord-319448-gt6uqfrl 65 1 These these DT cord-319448-gt6uqfrl 65 2 views view NNS cord-319448-gt6uqfrl 65 3 find find VBP cord-319448-gt6uqfrl 65 4 support support NN cord-319448-gt6uqfrl 65 5 in in IN cord-319448-gt6uqfrl 65 6 the the DT cord-319448-gt6uqfrl 65 7 observation observation NN cord-319448-gt6uqfrl 65 8 that that IN cord-319448-gt6uqfrl 65 9 immunocompromised immunocompromised JJ cord-319448-gt6uqfrl 65 10 hosts host NNS cord-319448-gt6uqfrl 65 11 have have VBP cord-319448-gt6uqfrl 65 12 a a DT cord-319448-gt6uqfrl 65 13 markedly markedly RB cord-319448-gt6uqfrl 65 14 increased increase VBN cord-319448-gt6uqfrl 65 15 incidence incidence NN cord-319448-gt6uqfrl 65 16 of of IN cord-319448-gt6uqfrl 65 17 Box Box NNP cord-319448-gt6uqfrl 65 18 1 1 CD cord-319448-gt6uqfrl 65 19 | | NNS cord-319448-gt6uqfrl 66 1 Basic basic JJ cord-319448-gt6uqfrl 66 2 tenets tenet NNS cord-319448-gt6uqfrl 66 3 of of IN cord-319448-gt6uqfrl 66 4 the the DT cord-319448-gt6uqfrl 66 5 damage damage NN cord-319448-gt6uqfrl 66 6 - - HYPH cord-319448-gt6uqfrl 66 7 response response NN cord-319448-gt6uqfrl 66 8 framework framework NN cord-319448-gt6uqfrl 67 1 • • NNP cord-319448-gt6uqfrl 68 1 Microbial microbial JJ cord-319448-gt6uqfrl 68 2 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 68 3 is be VBZ cord-319448-gt6uqfrl 68 4 an an DT cord-319448-gt6uqfrl 68 5 outcome outcome NN cord-319448-gt6uqfrl 68 6 of of IN cord-319448-gt6uqfrl 68 7 an an DT cord-319448-gt6uqfrl 68 8 interaction interaction NN cord-319448-gt6uqfrl 68 9 between between IN cord-319448-gt6uqfrl 68 10 a a DT cord-319448-gt6uqfrl 68 11 host host NN cord-319448-gt6uqfrl 68 12 and and CC cord-319448-gt6uqfrl 68 13 a a DT cord-319448-gt6uqfrl 68 14 microorganism microorganism NN cord-319448-gt6uqfrl 68 15 . . . cord-319448-gt6uqfrl 69 1 • • NNP cord-319448-gt6uqfrl 70 1 The the DT cord-319448-gt6uqfrl 70 2 host host NN cord-319448-gt6uqfrl 70 3 - - HYPH cord-319448-gt6uqfrl 70 4 relevant relevant JJ cord-319448-gt6uqfrl 70 5 outcome outcome NN cord-319448-gt6uqfrl 70 6 of of IN cord-319448-gt6uqfrl 70 7 the the DT cord-319448-gt6uqfrl 70 8 host host NN cord-319448-gt6uqfrl 70 9 - - HYPH cord-319448-gt6uqfrl 70 10 microorganism microorganism NN cord-319448-gt6uqfrl 70 11 interaction interaction NN cord-319448-gt6uqfrl 70 12 is be VBZ cord-319448-gt6uqfrl 70 13 determined determine VBN cord-319448-gt6uqfrl 70 14 by by IN cord-319448-gt6uqfrl 70 15 the the DT cord-319448-gt6uqfrl 70 16 amount amount NN cord-319448-gt6uqfrl 70 17 of of IN cord-319448-gt6uqfrl 70 18 damage damage NN cord-319448-gt6uqfrl 70 19 to to IN cord-319448-gt6uqfrl 70 20 the the DT cord-319448-gt6uqfrl 70 21 host host NN cord-319448-gt6uqfrl 70 22 . . . cord-319448-gt6uqfrl 71 1 • • NNP cord-319448-gt6uqfrl 72 1 Host host NN cord-319448-gt6uqfrl 72 2 damage damage NN cord-319448-gt6uqfrl 72 3 can can MD cord-319448-gt6uqfrl 72 4 result result VB cord-319448-gt6uqfrl 72 5 from from IN cord-319448-gt6uqfrl 72 6 microbial microbial JJ cord-319448-gt6uqfrl 72 7 factors factor NNS cord-319448-gt6uqfrl 72 8 and/or and/or CC cord-319448-gt6uqfrl 72 9 the the DT cord-319448-gt6uqfrl 72 10 host host NN cord-319448-gt6uqfrl 72 11 response response NN cord-319448-gt6uqfrl 72 12 . . . cord-319448-gt6uqfrl 73 1 as as IN cord-319448-gt6uqfrl 73 2 illustrated illustrate VBN cord-319448-gt6uqfrl 73 3 by by IN cord-319448-gt6uqfrl 73 4 the the DT cord-319448-gt6uqfrl 73 5 discovery discovery NN cord-319448-gt6uqfrl 73 6 that that WDT cord-319448-gt6uqfrl 73 7 P. P. NNP cord-319448-gt6uqfrl 73 8 carinii carinii NN cord-319448-gt6uqfrl 73 9 is be VBZ cord-319448-gt6uqfrl 73 10 a a DT cord-319448-gt6uqfrl 73 11 fungus fungus NN cord-319448-gt6uqfrl 73 12 after after IN cord-319448-gt6uqfrl 73 13 many many JJ cord-319448-gt6uqfrl 73 14 years year NNS cord-319448-gt6uqfrl 73 15 of of IN cord-319448-gt6uqfrl 73 16 being be VBG cord-319448-gt6uqfrl 73 17 considered consider VBN cord-319448-gt6uqfrl 73 18 a a DT cord-319448-gt6uqfrl 73 19 protozoan protozoan NN cord-319448-gt6uqfrl 73 20 parasite parasite NN cord-319448-gt6uqfrl 73 21 19 19 CD cord-319448-gt6uqfrl 73 22 . . . cord-319448-gt6uqfrl 74 1 Classifications classification NNS cord-319448-gt6uqfrl 74 2 based base VBN cord-319448-gt6uqfrl 74 3 on on IN cord-319448-gt6uqfrl 74 4 the the DT cord-319448-gt6uqfrl 74 5 perceived perceive VBN cord-319448-gt6uqfrl 74 6 capacity capacity NN cord-319448-gt6uqfrl 74 7 of of IN cord-319448-gt6uqfrl 74 8 a a DT cord-319448-gt6uqfrl 74 9 microorganism microorganism NN cord-319448-gt6uqfrl 74 10 to to TO cord-319448-gt6uqfrl 74 11 cause cause VB cord-319448-gt6uqfrl 74 12 disease disease NN cord-319448-gt6uqfrl 74 13 are be VBP cord-319448-gt6uqfrl 74 14 also also RB cord-319448-gt6uqfrl 74 15 inadequate inadequate JJ cord-319448-gt6uqfrl 74 16 , , , cord-319448-gt6uqfrl 74 17 because because IN cord-319448-gt6uqfrl 74 18 changes change NNS cord-319448-gt6uqfrl 74 19 in in IN cord-319448-gt6uqfrl 74 20 host host NN cord-319448-gt6uqfrl 74 21 immune immune JJ cord-319448-gt6uqfrl 74 22 function function NN cord-319448-gt6uqfrl 74 23 , , , cord-319448-gt6uqfrl 74 24 ecology ecology NN cord-319448-gt6uqfrl 74 25 and/or and/or CC cord-319448-gt6uqfrl 74 26 behaviour behaviour NN cord-319448-gt6uqfrl 74 27 can can MD cord-319448-gt6uqfrl 74 28 render render VB cord-319448-gt6uqfrl 74 29 them -PRON- PRP cord-319448-gt6uqfrl 74 30 obsolete obsolete JJ cord-319448-gt6uqfrl 74 31 . . . cord-319448-gt6uqfrl 75 1 For for IN cord-319448-gt6uqfrl 75 2 example example NN cord-319448-gt6uqfrl 75 3 , , , cord-319448-gt6uqfrl 75 4 Candida Candida NNP cord-319448-gt6uqfrl 75 5 spp spp NNS cord-319448-gt6uqfrl 75 6 . . . cord-319448-gt6uqfrl 75 7 were be VBD cord-319448-gt6uqfrl 75 8 considered consider VBN cord-319448-gt6uqfrl 75 9 essentially essentially RB cord-319448-gt6uqfrl 75 10 non non JJ cord-319448-gt6uqfrl 75 11 - - JJ cord-319448-gt6uqfrl 75 12 pathogenic pathogenic JJ cord-319448-gt6uqfrl 75 13 until until IN cord-319448-gt6uqfrl 75 14 the the DT cord-319448-gt6uqfrl 75 15 mid-1950s mid-1950 NNS cord-319448-gt6uqfrl 75 16 , , , cord-319448-gt6uqfrl 75 17 when when WRB cord-319448-gt6uqfrl 75 18 the the DT cord-319448-gt6uqfrl 75 19 introduction introduction NN cord-319448-gt6uqfrl 75 20 of of IN cord-319448-gt6uqfrl 75 21 antimicrobial antimicrobial JJ cord-319448-gt6uqfrl 75 22 chemotherapy chemotherapy NN cord-319448-gt6uqfrl 75 23 and and CC cord-319448-gt6uqfrl 75 24 corticosteroids corticosteroid NNS cord-319448-gt6uqfrl 75 25 resulted result VBD cord-319448-gt6uqfrl 75 26 in in IN cord-319448-gt6uqfrl 75 27 the the DT cord-319448-gt6uqfrl 75 28 recognition recognition NN cord-319448-gt6uqfrl 75 29 that that IN cord-319448-gt6uqfrl 75 30 they -PRON- PRP cord-319448-gt6uqfrl 75 31 could could MD cord-319448-gt6uqfrl 75 32 cause cause VB cord-319448-gt6uqfrl 75 33 disease disease NN cord-319448-gt6uqfrl 75 34 in in IN cord-319448-gt6uqfrl 75 35 certain certain JJ cord-319448-gt6uqfrl 75 36 hosts host NNS cord-319448-gt6uqfrl 75 37 20 20 CD cord-319448-gt6uqfrl 75 38 . . . cord-319448-gt6uqfrl 76 1 Similarly similarly RB cord-319448-gt6uqfrl 76 2 , , , cord-319448-gt6uqfrl 76 3 immunization immunization NN cord-319448-gt6uqfrl 76 4 can can MD cord-319448-gt6uqfrl 76 5 render render VB cord-319448-gt6uqfrl 76 6 a a DT cord-319448-gt6uqfrl 76 7 pathogenic pathogenic JJ cord-319448-gt6uqfrl 76 8 microorganism microorganism NN cord-319448-gt6uqfrl 76 9 a a DT cord-319448-gt6uqfrl 76 10 ' ' `` cord-319448-gt6uqfrl 76 11 nonpathogen nonpathogen NNP cord-319448-gt6uqfrl 76 12 ' ' '' cord-319448-gt6uqfrl 76 13 , , , cord-319448-gt6uqfrl 76 14 as as IN cord-319448-gt6uqfrl 76 15 host host NN cord-319448-gt6uqfrl 76 16 immunity immunity NN cord-319448-gt6uqfrl 76 17 abrogates abrogate VBZ cord-319448-gt6uqfrl 76 18 the the DT cord-319448-gt6uqfrl 76 19 ability ability NN cord-319448-gt6uqfrl 76 20 of of IN cord-319448-gt6uqfrl 76 21 the the DT cord-319448-gt6uqfrl 76 22 relevant relevant JJ cord-319448-gt6uqfrl 76 23 microorganism microorganism NN cord-319448-gt6uqfrl 76 24 to to TO cord-319448-gt6uqfrl 76 25 cause cause VB cord-319448-gt6uqfrl 76 26 disease disease NN cord-319448-gt6uqfrl 76 27 . . . cord-319448-gt6uqfrl 77 1 For for IN cord-319448-gt6uqfrl 77 2 example example NN cord-319448-gt6uqfrl 77 3 , , , cord-319448-gt6uqfrl 77 4 variola variola NN cord-319448-gt6uqfrl 77 5 virus virus NN cord-319448-gt6uqfrl 77 6 is be VBZ cord-319448-gt6uqfrl 77 7 not not RB cord-319448-gt6uqfrl 77 8 pathogenic pathogenic JJ cord-319448-gt6uqfrl 77 9 in in IN cord-319448-gt6uqfrl 77 10 individuals individual NNS cord-319448-gt6uqfrl 77 11 immunized immunize VBN cord-319448-gt6uqfrl 77 12 with with IN cord-319448-gt6uqfrl 77 13 vaccinia vaccinia NN cord-319448-gt6uqfrl 77 14 virus virus NN cord-319448-gt6uqfrl 77 15 . . . cord-319448-gt6uqfrl 78 1 The the DT cord-319448-gt6uqfrl 78 2 central central JJ cord-319448-gt6uqfrl 78 3 tenets tenet NNS cord-319448-gt6uqfrl 78 4 of of IN cord-319448-gt6uqfrl 78 5 the the DT cord-319448-gt6uqfrl 78 6 ' ' `` cord-319448-gt6uqfrl 78 7 damage damage NN cord-319448-gt6uqfrl 78 8 - - HYPH cord-319448-gt6uqfrl 78 9 response response NN cord-319448-gt6uqfrl 78 10 ' ' '' cord-319448-gt6uqfrl 78 11 framework framework NN cord-319448-gt6uqfrl 78 12 -that -that NN cord-319448-gt6uqfrl 79 1 the the DT cord-319448-gt6uqfrl 79 2 outcome outcome NN cord-319448-gt6uqfrl 79 3 of of IN cord-319448-gt6uqfrl 79 4 microbial microbial JJ cord-319448-gt6uqfrl 79 5 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 79 6 is be VBZ cord-319448-gt6uqfrl 79 7 the the DT cord-319448-gt6uqfrl 79 8 result result NN cord-319448-gt6uqfrl 79 9 of of IN cord-319448-gt6uqfrl 79 10 a a DT cord-319448-gt6uqfrl 79 11 host host NN cord-319448-gt6uqfrl 79 12 - - HYPH cord-319448-gt6uqfrl 79 13 microorganism microorganism NN cord-319448-gt6uqfrl 79 14 interaction interaction NN cord-319448-gt6uqfrl 79 15 , , , cord-319448-gt6uqfrl 79 16 and and CC cord-319448-gt6uqfrl 79 17 that that IN cord-319448-gt6uqfrl 79 18 the the DT cord-319448-gt6uqfrl 79 19 relevant relevant JJ cord-319448-gt6uqfrl 79 20 outcome outcome NN cord-319448-gt6uqfrl 79 21 of of IN cord-319448-gt6uqfrl 79 22 this this DT cord-319448-gt6uqfrl 79 23 interaction interaction NN cord-319448-gt6uqfrl 79 24 is be VBZ cord-319448-gt6uqfrl 79 25 host host NN cord-319448-gt6uqfrl 79 26 damage damage NN cord-319448-gt6uqfrl 80 1 -provide -provide : cord-319448-gt6uqfrl 81 1 the the DT cord-319448-gt6uqfrl 81 2 basis basis NN cord-319448-gt6uqfrl 81 3 for for IN cord-319448-gt6uqfrl 81 4 a a DT cord-319448-gt6uqfrl 81 5 new new JJ cord-319448-gt6uqfrl 81 6 pathogen pathogen NN cord-319448-gt6uqfrl 81 7 - - HYPH cord-319448-gt6uqfrl 81 8 classification classification NN cord-319448-gt6uqfrl 81 9 scheme scheme NN cord-319448-gt6uqfrl 81 10 . . . cord-319448-gt6uqfrl 82 1 This this DT cord-319448-gt6uqfrl 82 2 scheme scheme NN cord-319448-gt6uqfrl 82 3 is be VBZ cord-319448-gt6uqfrl 82 4 based base VBN cord-319448-gt6uqfrl 82 5 on on IN cord-319448-gt6uqfrl 82 6 damage damage NN cord-319448-gt6uqfrl 82 7 - - HYPH cord-319448-gt6uqfrl 82 8 response response NN cord-319448-gt6uqfrl 82 9 curves curve NNS cord-319448-gt6uqfrl 82 10 , , , cord-319448-gt6uqfrl 82 11 which which WDT cord-319448-gt6uqfrl 82 12 depict depict VBP cord-319448-gt6uqfrl 82 13 the the DT cord-319448-gt6uqfrl 82 14 host host NN cord-319448-gt6uqfrl 82 15 - - HYPH cord-319448-gt6uqfrl 82 16 microorganism microorganism NN cord-319448-gt6uqfrl 82 17 interaction interaction NN cord-319448-gt6uqfrl 82 18 ( ( -LRB- cord-319448-gt6uqfrl 82 19 FIG fig NN cord-319448-gt6uqfrl 82 20 . . . cord-319448-gt6uqfrl 82 21 1 1 CD cord-319448-gt6uqfrl 82 22 ) ) -RRB- cord-319448-gt6uqfrl 82 23 . . . cord-319448-gt6uqfrl 83 1 It -PRON- PRP cord-319448-gt6uqfrl 83 2 consists consist VBZ cord-319448-gt6uqfrl 83 3 of of IN cord-319448-gt6uqfrl 83 4 six six CD cord-319448-gt6uqfrl 83 5 different different JJ cord-319448-gt6uqfrl 83 6 parabolic parabolic JJ cord-319448-gt6uqfrl 83 7 curves curve NNS cord-319448-gt6uqfrl 83 8 that that WDT cord-319448-gt6uqfrl 83 9 represent represent VBP cord-319448-gt6uqfrl 83 10 the the DT cord-319448-gt6uqfrl 83 11 amount amount NN cord-319448-gt6uqfrl 83 12 of of IN cord-319448-gt6uqfrl 83 13 host host NN cord-319448-gt6uqfrl 83 14 damage damage NN cord-319448-gt6uqfrl 83 15 as as IN cord-319448-gt6uqfrl 83 16 a a DT cord-319448-gt6uqfrl 83 17 function function NN cord-319448-gt6uqfrl 83 18 of of IN cord-319448-gt6uqfrl 83 19 the the DT cord-319448-gt6uqfrl 83 20 intensity intensity NN cord-319448-gt6uqfrl 83 21 and and CC cord-319448-gt6uqfrl 83 22 degree degree NN cord-319448-gt6uqfrl 83 23 of of IN cord-319448-gt6uqfrl 83 24 the the DT cord-319448-gt6uqfrl 83 25 host host NN cord-319448-gt6uqfrl 83 26 response response NN cord-319448-gt6uqfrl 83 27 . . . cord-319448-gt6uqfrl 84 1 Each each DT cord-319448-gt6uqfrl 84 2 type type NN cord-319448-gt6uqfrl 84 3 of of IN cord-319448-gt6uqfrl 84 4 curve curve NN cord-319448-gt6uqfrl 84 5 represents represent VBZ cord-319448-gt6uqfrl 84 6 a a DT cord-319448-gt6uqfrl 84 7 type type NN cord-319448-gt6uqfrl 84 8 or or CC cord-319448-gt6uqfrl 84 9 a a DT cord-319448-gt6uqfrl 84 10 ' ' `` cord-319448-gt6uqfrl 84 11 class class NN cord-319448-gt6uqfrl 84 12 ' ' '' cord-319448-gt6uqfrl 84 13 of of IN cord-319448-gt6uqfrl 84 14 pathogen pathogen NN cord-319448-gt6uqfrl 84 15 ( ( -LRB- cord-319448-gt6uqfrl 84 16 FIG fig NN cord-319448-gt6uqfrl 84 17 . . . cord-319448-gt6uqfrl 84 18 2 2 CD cord-319448-gt6uqfrl 84 19 ) ) -RRB- cord-319448-gt6uqfrl 84 20 . . . cord-319448-gt6uqfrl 85 1 In in IN cord-319448-gt6uqfrl 85 2 the the DT cord-319448-gt6uqfrl 85 3 absence absence NN cord-319448-gt6uqfrl 85 4 of of IN cord-319448-gt6uqfrl 85 5 a a DT cord-319448-gt6uqfrl 85 6 host host NN cord-319448-gt6uqfrl 85 7 response response NN cord-319448-gt6uqfrl 85 8 , , , cord-319448-gt6uqfrl 85 9 damage damage NN cord-319448-gt6uqfrl 85 10 is be VBZ cord-319448-gt6uqfrl 85 11 the the DT cord-319448-gt6uqfrl 85 12 result result NN cord-319448-gt6uqfrl 85 13 of of IN cord-319448-gt6uqfrl 85 14 the the DT cord-319448-gt6uqfrl 85 15 ability ability NN cord-319448-gt6uqfrl 85 16 of of IN cord-319448-gt6uqfrl 85 17 the the DT cord-319448-gt6uqfrl 85 18 microorganism microorganism NN cord-319448-gt6uqfrl 85 19 to to TO cord-319448-gt6uqfrl 85 20 induce induce VB cord-319448-gt6uqfrl 85 21 damage damage NN cord-319448-gt6uqfrl 85 22 . . . cord-319448-gt6uqfrl 86 1 However however RB cord-319448-gt6uqfrl 86 2 , , , cord-319448-gt6uqfrl 86 3 it -PRON- PRP cord-319448-gt6uqfrl 86 4 is be VBZ cord-319448-gt6uqfrl 86 5 likely likely JJ cord-319448-gt6uqfrl 86 6 that that IN cord-319448-gt6uqfrl 86 7 most most JJS cord-319448-gt6uqfrl 86 8 , , , cord-319448-gt6uqfrl 86 9 if if IN cord-319448-gt6uqfrl 86 10 not not RB cord-319448-gt6uqfrl 86 11 all all DT cord-319448-gt6uqfrl 86 12 , , , cord-319448-gt6uqfrl 86 13 hosts host NNS cord-319448-gt6uqfrl 86 14 generate generate VBP cord-319448-gt6uqfrl 86 15 some some DT cord-319448-gt6uqfrl 86 16 degree degree NN cord-319448-gt6uqfrl 86 17 of of IN cord-319448-gt6uqfrl 86 18 response response NN cord-319448-gt6uqfrl 86 19 to to IN cord-319448-gt6uqfrl 86 20 microbial microbial JJ cord-319448-gt6uqfrl 86 21 infection infection NN cord-319448-gt6uqfrl 86 22 and and CC cord-319448-gt6uqfrl 86 23 that that IN cord-319448-gt6uqfrl 86 24 many many JJ cord-319448-gt6uqfrl 86 25 mechanisms mechanism NNS cord-319448-gt6uqfrl 86 26 that that WDT cord-319448-gt6uqfrl 86 27 produce produce VBP cord-319448-gt6uqfrl 86 28 this this DT cord-319448-gt6uqfrl 86 29 response response NN cord-319448-gt6uqfrl 86 30 have have VB cord-319448-gt6uqfrl 86 31 the the DT cord-319448-gt6uqfrl 86 32 capacity capacity NN cord-319448-gt6uqfrl 86 33 to to TO cord-319448-gt6uqfrl 86 34 induce induce VB cord-319448-gt6uqfrl 86 35 host host NN cord-319448-gt6uqfrl 86 36 damage damage NN cord-319448-gt6uqfrl 86 37 . . . cord-319448-gt6uqfrl 87 1 The the DT cord-319448-gt6uqfrl 87 2 use use NN cord-319448-gt6uqfrl 87 3 of of IN cord-319448-gt6uqfrl 87 4 host host NN cord-319448-gt6uqfrl 87 5 damage damage NN cord-319448-gt6uqfrl 87 6 as as IN cord-319448-gt6uqfrl 87 7 the the DT cord-319448-gt6uqfrl 87 8 common common JJ cord-319448-gt6uqfrl 87 9 principle principle NN cord-319448-gt6uqfrl 87 10 to to TO cord-319448-gt6uqfrl 87 11 classify classify VB cord-319448-gt6uqfrl 87 12 pathogens pathogen NNS cord-319448-gt6uqfrl 87 13 allows allow VBZ cord-319448-gt6uqfrl 87 14 them -PRON- PRP cord-319448-gt6uqfrl 87 15 to to TO cord-319448-gt6uqfrl 87 16 be be VB cord-319448-gt6uqfrl 87 17 grouped group VBN cord-319448-gt6uqfrl 87 18 according accord VBG cord-319448-gt6uqfrl 87 19 to to IN cord-319448-gt6uqfrl 87 20 common common JJ cord-319448-gt6uqfrl 87 21 pathogenic pathogenic JJ cord-319448-gt6uqfrl 87 22 outcomes outcome NNS cord-319448-gt6uqfrl 87 23 . . . cord-319448-gt6uqfrl 88 1 Microorganisms microorganism NNS cord-319448-gt6uqfrl 88 2 that that WDT cord-319448-gt6uqfrl 88 3 cause cause VBP cord-319448-gt6uqfrl 88 4 similar similar JJ cord-319448-gt6uqfrl 88 5 types type NNS cord-319448-gt6uqfrl 88 6 of of IN cord-319448-gt6uqfrl 88 7 diseases disease NNS cord-319448-gt6uqfrl 88 8 can can MD cord-319448-gt6uqfrl 88 9 be be VB cord-319448-gt6uqfrl 88 10 grouped group VBN cord-319448-gt6uqfrl 88 11 together together RB cord-319448-gt6uqfrl 88 12 -despite -despite RB cord-319448-gt6uqfrl 89 1 their -PRON- PRP$ cord-319448-gt6uqfrl 89 2 differences difference NNS cord-319448-gt6uqfrl 89 3 at at IN cord-319448-gt6uqfrl 89 4 the the DT cord-319448-gt6uqfrl 89 5 level level NN cord-319448-gt6uqfrl 89 6 of of IN cord-319448-gt6uqfrl 89 7 phylogeny phylogeny NN cord-319448-gt6uqfrl 89 8 , , , cord-319448-gt6uqfrl 89 9 growth growth NN cord-319448-gt6uqfrl 89 10 characteristics characteristic NNS cord-319448-gt6uqfrl 89 11 or or CC cord-319448-gt6uqfrl 89 12 other other JJ cord-319448-gt6uqfrl 89 13 criteria criterion NNS cord-319448-gt6uqfrl 89 14 that that WDT cord-319448-gt6uqfrl 89 15 are be VBP cord-319448-gt6uqfrl 89 16 used use VBN cord-319448-gt6uqfrl 89 17 for for IN cord-319448-gt6uqfrl 89 18 pathogen pathogen NN cord-319448-gt6uqfrl 89 19 classification classification NN cord-319448-gt6uqfrl 89 20 . . . cord-319448-gt6uqfrl 90 1 The the DT cord-319448-gt6uqfrl 90 2 pathogens pathogen NNS cord-319448-gt6uqfrl 90 3 that that WDT cord-319448-gt6uqfrl 90 4 are be VBP cord-319448-gt6uqfrl 90 5 grouped group VBN cord-319448-gt6uqfrl 90 6 in in IN cord-319448-gt6uqfrl 90 7 a a DT cord-319448-gt6uqfrl 90 8 single single JJ cord-319448-gt6uqfrl 90 9 class class NN cord-319448-gt6uqfrl 90 10 might may MD cord-319448-gt6uqfrl 90 11 not not RB cord-319448-gt6uqfrl 90 12 cause cause VB cord-319448-gt6uqfrl 90 13 similar similar JJ cord-319448-gt6uqfrl 90 14 diseases disease NNS cord-319448-gt6uqfrl 90 15 , , , cord-319448-gt6uqfrl 90 16 but but CC cord-319448-gt6uqfrl 90 17 what what WP cord-319448-gt6uqfrl 90 18 they -PRON- PRP cord-319448-gt6uqfrl 90 19 have have VBP cord-319448-gt6uqfrl 90 20 in in IN cord-319448-gt6uqfrl 90 21 common common JJ cord-319448-gt6uqfrl 90 22 is be VBZ cord-319448-gt6uqfrl 90 23 the the DT cord-319448-gt6uqfrl 90 24 extent extent NN cord-319448-gt6uqfrl 90 25 to to TO cord-319448-gt6uqfrl 90 26 which which WDT cord-319448-gt6uqfrl 90 27 the the DT cord-319448-gt6uqfrl 90 28 damage damage NN cord-319448-gt6uqfrl 90 29 or or CC cord-319448-gt6uqfrl 90 30 disease disease NN cord-319448-gt6uqfrl 90 31 they -PRON- PRP cord-319448-gt6uqfrl 90 32 cause cause VBP cord-319448-gt6uqfrl 90 33 is be VBZ cord-319448-gt6uqfrl 90 34 a a DT cord-319448-gt6uqfrl 90 35 function function NN cord-319448-gt6uqfrl 90 36 of of IN cord-319448-gt6uqfrl 90 37 the the DT cord-319448-gt6uqfrl 90 38 host host NN cord-319448-gt6uqfrl 90 39 immune immune JJ cord-319448-gt6uqfrl 90 40 response response NN cord-319448-gt6uqfrl 90 41 . . . cord-319448-gt6uqfrl 91 1 Therefore therefore RB cord-319448-gt6uqfrl 91 2 , , , cord-319448-gt6uqfrl 91 3 the the DT cord-319448-gt6uqfrl 91 4 pathogen pathogen NN cord-319448-gt6uqfrl 91 5 classes class NNS cord-319448-gt6uqfrl 91 6 convey convey VBP cord-319448-gt6uqfrl 91 7 the the DT cord-319448-gt6uqfrl 91 8 relative relative JJ cord-319448-gt6uqfrl 91 9 ability ability NN cord-319448-gt6uqfrl 91 10 of of IN cord-319448-gt6uqfrl 91 11 a a DT cord-319448-gt6uqfrl 91 12 microorganism microorganism NN cord-319448-gt6uqfrl 91 13 to to TO cord-319448-gt6uqfrl 91 14 cause cause VB cord-319448-gt6uqfrl 91 15 disease disease NN cord-319448-gt6uqfrl 91 16 based base VBN cord-319448-gt6uqfrl 91 17 on on IN cord-319448-gt6uqfrl 91 18 the the DT cord-319448-gt6uqfrl 91 19 immune immune JJ cord-319448-gt6uqfrl 91 20 status status NN cord-319448-gt6uqfrl 91 21 of of IN cord-319448-gt6uqfrl 91 22 In in IN cord-319448-gt6uqfrl 91 23 the the DT cord-319448-gt6uqfrl 91 24 damage damage NN cord-319448-gt6uqfrl 91 25 - - HYPH cord-319448-gt6uqfrl 91 26 response response NN cord-319448-gt6uqfrl 91 27 framework framework NN cord-319448-gt6uqfrl 91 28 , , , cord-319448-gt6uqfrl 91 29 a a DT cord-319448-gt6uqfrl 91 30 pathogen pathogen NN cord-319448-gt6uqfrl 91 31 is be VBZ cord-319448-gt6uqfrl 91 32 defined define VBN cord-319448-gt6uqfrl 91 33 as as IN cord-319448-gt6uqfrl 91 34 a a DT cord-319448-gt6uqfrl 91 35 microorganism microorganism NN cord-319448-gt6uqfrl 91 36 that that WDT cord-319448-gt6uqfrl 91 37 is be VBZ cord-319448-gt6uqfrl 91 38 capable capable JJ cord-319448-gt6uqfrl 91 39 of of IN cord-319448-gt6uqfrl 91 40 causing cause VBG cord-319448-gt6uqfrl 91 41 damage damage NN cord-319448-gt6uqfrl 91 42 to to IN cord-319448-gt6uqfrl 91 43 a a DT cord-319448-gt6uqfrl 91 44 host host NN cord-319448-gt6uqfrl 91 45 1,3 1,3 CD cord-319448-gt6uqfrl 91 46 . . . cord-319448-gt6uqfrl 92 1 This this DT cord-319448-gt6uqfrl 92 2 definition definition NN cord-319448-gt6uqfrl 92 3 allows allow VBZ cord-319448-gt6uqfrl 92 4 the the DT cord-319448-gt6uqfrl 92 5 terms term NNS cord-319448-gt6uqfrl 92 6 that that WDT cord-319448-gt6uqfrl 92 7 have have VBP cord-319448-gt6uqfrl 92 8 been be VBN cord-319448-gt6uqfrl 92 9 used use VBN cord-319448-gt6uqfrl 92 10 to to TO cord-319448-gt6uqfrl 92 11 define define VB cord-319448-gt6uqfrl 92 12 microorganisms microorganism NNS cord-319448-gt6uqfrl 92 13 that that WDT cord-319448-gt6uqfrl 92 14 do do VBP cord-319448-gt6uqfrl 92 15 , , , cord-319448-gt6uqfrl 92 16 and and CC cord-319448-gt6uqfrl 92 17 do do VB cord-319448-gt6uqfrl 92 18 not not RB cord-319448-gt6uqfrl 92 19 cause cause VB cord-319448-gt6uqfrl 92 20 disease disease NN cord-319448-gt6uqfrl 92 21 , , , cord-319448-gt6uqfrl 92 22 such such JJ cord-319448-gt6uqfrl 92 23 as as IN cord-319448-gt6uqfrl 92 24 commensal commensal JJ cord-319448-gt6uqfrl 92 25 , , , cord-319448-gt6uqfrl 92 26 saprophyte saprophyte NNP cord-319448-gt6uqfrl 92 27 , , , cord-319448-gt6uqfrl 92 28 non non JJ cord-319448-gt6uqfrl 92 29 - - JJ cord-319448-gt6uqfrl 92 30 pathogen pathogen JJ cord-319448-gt6uqfrl 92 31 , , , cord-319448-gt6uqfrl 92 32 opportunist opportunist NN cord-319448-gt6uqfrl 92 33 and and CC cord-319448-gt6uqfrl 92 34 primary primary JJ cord-319448-gt6uqfrl 92 35 pathogen pathogen NN cord-319448-gt6uqfrl 92 36 , , , cord-319448-gt6uqfrl 92 37 to to TO cord-319448-gt6uqfrl 92 38 be be VB cord-319448-gt6uqfrl 92 39 dispensed dispense VBN cord-319448-gt6uqfrl 92 40 with with IN cord-319448-gt6uqfrl 92 41 . . . cord-319448-gt6uqfrl 93 1 This this DT cord-319448-gt6uqfrl 93 2 is be VBZ cord-319448-gt6uqfrl 93 3 a a DT cord-319448-gt6uqfrl 93 4 less less RBR cord-319448-gt6uqfrl 93 5 ambiguous ambiguous JJ cord-319448-gt6uqfrl 93 6 definition definition NN cord-319448-gt6uqfrl 93 7 of of IN cord-319448-gt6uqfrl 93 8 a a DT cord-319448-gt6uqfrl 93 9 pathogen pathogen NN cord-319448-gt6uqfrl 93 10 than than IN cord-319448-gt6uqfrl 93 11 that that DT cord-319448-gt6uqfrl 93 12 used use VBN cord-319448-gt6uqfrl 93 13 previously previously RB cord-319448-gt6uqfrl 93 14 , , , cord-319448-gt6uqfrl 93 15 as as IN cord-319448-gt6uqfrl 93 16 the the DT cord-319448-gt6uqfrl 93 17 outcome outcome NN cord-319448-gt6uqfrl 93 18 or or CC cord-319448-gt6uqfrl 93 19 possible possible JJ cord-319448-gt6uqfrl 93 20 outcomes outcome NNS cord-319448-gt6uqfrl 93 21 of of IN cord-319448-gt6uqfrl 93 22 damage damage NN cord-319448-gt6uqfrl 93 23 are be VBP cord-319448-gt6uqfrl 93 24 used use VBN cord-319448-gt6uqfrl 93 25 to to TO cord-319448-gt6uqfrl 93 26 define define VB cord-319448-gt6uqfrl 93 27 the the DT cord-319448-gt6uqfrl 93 28 pathogen pathogen NN cord-319448-gt6uqfrl 93 29 , , , cord-319448-gt6uqfrl 93 30 and and CC cord-319448-gt6uqfrl 93 31 it -PRON- PRP cord-319448-gt6uqfrl 93 32 dispenses dispense VBZ cord-319448-gt6uqfrl 93 33 with with IN cord-319448-gt6uqfrl 93 34 the the DT cord-319448-gt6uqfrl 93 35 need need NN cord-319448-gt6uqfrl 93 36 for for IN cord-319448-gt6uqfrl 93 37 modification modification NN cord-319448-gt6uqfrl 93 38 or or CC cord-319448-gt6uqfrl 93 39 qualification qualification NN cord-319448-gt6uqfrl 93 40 to to TO cord-319448-gt6uqfrl 93 41 encompass encompass VB cord-319448-gt6uqfrl 93 42 microorganisms microorganism NNS cord-319448-gt6uqfrl 93 43 that that WDT cord-319448-gt6uqfrl 93 44 cause cause VBP cord-319448-gt6uqfrl 93 45 disease disease NN cord-319448-gt6uqfrl 93 46 rarely rarely RB cord-319448-gt6uqfrl 93 47 , , , cord-319448-gt6uqfrl 93 48 or or CC cord-319448-gt6uqfrl 93 49 only only RB cord-319448-gt6uqfrl 93 50 in in IN cord-319448-gt6uqfrl 93 51 certain certain JJ cord-319448-gt6uqfrl 93 52 hosts host NNS cord-319448-gt6uqfrl 93 53 . . . cord-319448-gt6uqfrl 94 1 In in IN cord-319448-gt6uqfrl 94 2 the the DT cord-319448-gt6uqfrl 94 3 past past NN cord-319448-gt6uqfrl 94 4 , , , cord-319448-gt6uqfrl 94 5 the the DT cord-319448-gt6uqfrl 94 6 meaning meaning NN cord-319448-gt6uqfrl 94 7 of of IN cord-319448-gt6uqfrl 94 8 the the DT cord-319448-gt6uqfrl 94 9 word word NN cord-319448-gt6uqfrl 94 10 ' ' `` cord-319448-gt6uqfrl 94 11 virulence virulence NN cord-319448-gt6uqfrl 94 12 ' ' '' cord-319448-gt6uqfrl 94 13 has have VBZ cord-319448-gt6uqfrl 94 14 also also RB cord-319448-gt6uqfrl 94 15 caused cause VBN cord-319448-gt6uqfrl 94 16 confusion confusion NN cord-319448-gt6uqfrl 94 17 1 1 CD cord-319448-gt6uqfrl 94 18 . . . cord-319448-gt6uqfrl 95 1 The the DT cord-319448-gt6uqfrl 95 2 damageresponse damageresponse NN cord-319448-gt6uqfrl 95 3 framework framework NN cord-319448-gt6uqfrl 95 4 defines define VBZ cord-319448-gt6uqfrl 95 5 virulence virulence NN cord-319448-gt6uqfrl 95 6 as as IN cord-319448-gt6uqfrl 95 7 the the DT cord-319448-gt6uqfrl 95 8 relative relative JJ cord-319448-gt6uqfrl 95 9 capacity capacity NN cord-319448-gt6uqfrl 95 10 of of IN cord-319448-gt6uqfrl 95 11 a a DT cord-319448-gt6uqfrl 95 12 microorganism microorganism NN cord-319448-gt6uqfrl 95 13 to to TO cord-319448-gt6uqfrl 95 14 cause cause VB cord-319448-gt6uqfrl 95 15 damage damage NN cord-319448-gt6uqfrl 95 16 to to IN cord-319448-gt6uqfrl 95 17 a a DT cord-319448-gt6uqfrl 95 18 host host NN cord-319448-gt6uqfrl 95 19 1 1 CD cord-319448-gt6uqfrl 95 20 . . . cord-319448-gt6uqfrl 96 1 The the DT cord-319448-gt6uqfrl 96 2 word word NN cord-319448-gt6uqfrl 96 3 ' ' `` cord-319448-gt6uqfrl 96 4 relative relative JJ cord-319448-gt6uqfrl 96 5 ' ' '' cord-319448-gt6uqfrl 96 6 is be VBZ cord-319448-gt6uqfrl 96 7 included include VBN cord-319448-gt6uqfrl 96 8 because because IN cord-319448-gt6uqfrl 96 9 virulence virulence NN cord-319448-gt6uqfrl 96 10 is be VBZ cord-319448-gt6uqfrl 96 11 frequently frequently RB cord-319448-gt6uqfrl 96 12 measured measure VBN cord-319448-gt6uqfrl 96 13 in in IN cord-319448-gt6uqfrl 96 14 comparison comparison NN cord-319448-gt6uqfrl 96 15 with with IN cord-319448-gt6uqfrl 96 16 another another DT cord-319448-gt6uqfrl 96 17 microorganism microorganism NN cord-319448-gt6uqfrl 96 18 or or CC cord-319448-gt6uqfrl 96 19 a a DT cord-319448-gt6uqfrl 96 20 variant variant NN cord-319448-gt6uqfrl 96 21 of of IN cord-319448-gt6uqfrl 96 22 the the DT cord-319448-gt6uqfrl 96 23 same same JJ cord-319448-gt6uqfrl 96 24 microorganism microorganism NN cord-319448-gt6uqfrl 96 25 . . . cord-319448-gt6uqfrl 97 1 However however RB cord-319448-gt6uqfrl 97 2 , , , cord-319448-gt6uqfrl 97 3 when when WRB cord-319448-gt6uqfrl 97 4 a a DT cord-319448-gt6uqfrl 97 5 more more RBR cord-319448-gt6uqfrl 97 6 complete complete JJ cord-319448-gt6uqfrl 97 7 understanding understanding NN cord-319448-gt6uqfrl 97 8 of of IN cord-319448-gt6uqfrl 97 9 quantitative quantitative JJ cord-319448-gt6uqfrl 97 10 measures measure NNS cord-319448-gt6uqfrl 97 11 of of IN cord-319448-gt6uqfrl 97 12 damage damage NN cord-319448-gt6uqfrl 97 13 is be VBZ cord-319448-gt6uqfrl 97 14 available available JJ cord-319448-gt6uqfrl 97 15 , , , cord-319448-gt6uqfrl 97 16 it -PRON- PRP cord-319448-gt6uqfrl 97 17 should should MD cord-319448-gt6uqfrl 97 18 be be VB cord-319448-gt6uqfrl 97 19 possible possible JJ cord-319448-gt6uqfrl 97 20 to to TO cord-319448-gt6uqfrl 97 21 dispense dispense VB cord-319448-gt6uqfrl 97 22 with with IN cord-319448-gt6uqfrl 97 23 the the DT cord-319448-gt6uqfrl 97 24 word word NN cord-319448-gt6uqfrl 97 25 ' ' `` cord-319448-gt6uqfrl 97 26 relative relative JJ cord-319448-gt6uqfrl 97 27 ' ' '' cord-319448-gt6uqfrl 97 28 . . . cord-319448-gt6uqfrl 98 1 The the DT cord-319448-gt6uqfrl 98 2 damage damage NN cord-319448-gt6uqfrl 98 3 - - HYPH cord-319448-gt6uqfrl 98 4 response response NN cord-319448-gt6uqfrl 98 5 framework framework NN cord-319448-gt6uqfrl 98 6 definitions definition NNS cord-319448-gt6uqfrl 98 7 of of IN cord-319448-gt6uqfrl 98 8 pathogen pathogen NN cord-319448-gt6uqfrl 98 9 and and CC cord-319448-gt6uqfrl 98 10 virulence virulence NN cord-319448-gt6uqfrl 98 11 underscore underscore VBP cord-319448-gt6uqfrl 98 12 the the DT cord-319448-gt6uqfrl 98 13 concept concept NN cord-319448-gt6uqfrl 98 14 that that IN cord-319448-gt6uqfrl 98 15 only only RB cord-319448-gt6uqfrl 98 16 in in IN cord-319448-gt6uqfrl 98 17 a a DT cord-319448-gt6uqfrl 98 18 susceptible susceptible JJ cord-319448-gt6uqfrl 98 19 host host NN cord-319448-gt6uqfrl 98 20 is be VBZ cord-319448-gt6uqfrl 98 21 a a DT cord-319448-gt6uqfrl 98 22 microorganism microorganism NN cord-319448-gt6uqfrl 98 23 a a DT cord-319448-gt6uqfrl 98 24 pathogen pathogen NN cord-319448-gt6uqfrl 98 25 , , , cord-319448-gt6uqfrl 98 26 and and CC cord-319448-gt6uqfrl 98 27 virulence virulence NN cord-319448-gt6uqfrl 98 28 can can MD cord-319448-gt6uqfrl 98 29 be be VB cord-319448-gt6uqfrl 98 30 expressed express VBN cord-319448-gt6uqfrl 98 31 4 4 CD cord-319448-gt6uqfrl 98 32 . . . cord-319448-gt6uqfrl 99 1 Consequently consequently RB cord-319448-gt6uqfrl 99 2 , , , cord-319448-gt6uqfrl 99 3 neither neither CC cord-319448-gt6uqfrl 99 4 the the DT cord-319448-gt6uqfrl 99 5 characteristics characteristic NNS cord-319448-gt6uqfrl 99 6 of of IN cord-319448-gt6uqfrl 99 7 a a DT cord-319448-gt6uqfrl 99 8 pathogen pathogen NN cord-319448-gt6uqfrl 99 9 , , , cord-319448-gt6uqfrl 99 10 nor nor CC cord-319448-gt6uqfrl 99 11 virulence virulence NN cord-319448-gt6uqfrl 99 12 , , , cord-319448-gt6uqfrl 99 13 can can MD cord-319448-gt6uqfrl 99 14 be be VB cord-319448-gt6uqfrl 99 15 considered consider VBN cord-319448-gt6uqfrl 99 16 independent independent JJ cord-319448-gt6uqfrl 99 17 microbial microbial JJ cord-319448-gt6uqfrl 99 18 variables variable NNS cord-319448-gt6uqfrl 99 19 . . . cord-319448-gt6uqfrl 100 1 At at IN cord-319448-gt6uqfrl 100 2 present present JJ cord-319448-gt6uqfrl 100 3 , , , cord-319448-gt6uqfrl 100 4 microbial microbial JJ cord-319448-gt6uqfrl 100 5 classifications classification NNS cord-319448-gt6uqfrl 100 6 are be VBP cord-319448-gt6uqfrl 100 7 largely largely RB cord-319448-gt6uqfrl 100 8 based base VBN cord-319448-gt6uqfrl 100 9 on on IN cord-319448-gt6uqfrl 100 10 phylogenetic phylogenetic JJ cord-319448-gt6uqfrl 100 11 groupings grouping NNS cord-319448-gt6uqfrl 100 12 ( ( -LRB- cord-319448-gt6uqfrl 100 13 for for IN cord-319448-gt6uqfrl 100 14 example example NN cord-319448-gt6uqfrl 100 15 , , , cord-319448-gt6uqfrl 100 16 bacteria bacteria NNS cord-319448-gt6uqfrl 100 17 , , , cord-319448-gt6uqfrl 100 18 viruses virus NNS cord-319448-gt6uqfrl 100 19 , , , cord-319448-gt6uqfrl 100 20 parasites parasite NNS cord-319448-gt6uqfrl 100 21 and and CC cord-319448-gt6uqfrl 100 22 fungi fungus NNS cord-319448-gt6uqfrl 100 23 ) ) -RRB- cord-319448-gt6uqfrl 100 24 , , , cord-319448-gt6uqfrl 100 25 the the DT cord-319448-gt6uqfrl 100 26 perceived perceive VBN cord-319448-gt6uqfrl 100 27 capacity capacity NN cord-319448-gt6uqfrl 100 28 to to TO cord-319448-gt6uqfrl 100 29 cause cause VB cord-319448-gt6uqfrl 100 30 disease disease NN cord-319448-gt6uqfrl 100 31 ( ( -LRB- cord-319448-gt6uqfrl 100 32 for for IN cord-319448-gt6uqfrl 100 33 example example NN cord-319448-gt6uqfrl 100 34 , , , cord-319448-gt6uqfrl 100 35 primary primary JJ cord-319448-gt6uqfrl 100 36 pathogens pathogen NNS cord-319448-gt6uqfrl 100 37 , , , cord-319448-gt6uqfrl 100 38 saprophytes saprophyte NNS cord-319448-gt6uqfrl 100 39 , , , cord-319448-gt6uqfrl 100 40 opportunistic opportunistic JJ cord-319448-gt6uqfrl 100 41 pathogens pathogen NNS cord-319448-gt6uqfrl 100 42 or or CC cord-319448-gt6uqfrl 100 43 commensals commensal NNS cord-319448-gt6uqfrl 100 44 ) ) -RRB- cord-319448-gt6uqfrl 100 45 or or CC cord-319448-gt6uqfrl 100 46 , , , cord-319448-gt6uqfrl 100 47 for for IN cord-319448-gt6uqfrl 100 48 bacteria bacteria NNS cord-319448-gt6uqfrl 100 49 , , , cord-319448-gt6uqfrl 100 50 growth growth NN cord-319448-gt6uqfrl 100 51 or or CC cord-319448-gt6uqfrl 100 52 other other JJ cord-319448-gt6uqfrl 100 53 identifying identify VBG cord-319448-gt6uqfrl 100 54 characteristics characteristic NNS cord-319448-gt6uqfrl 100 55 ( ( -LRB- cord-319448-gt6uqfrl 100 56 for for IN cord-319448-gt6uqfrl 100 57 example example NN cord-319448-gt6uqfrl 100 58 , , , cord-319448-gt6uqfrl 100 59 whether whether IN cord-319448-gt6uqfrl 100 60 it -PRON- PRP cord-319448-gt6uqfrl 100 61 is be VBZ cord-319448-gt6uqfrl 100 62 an an DT cord-319448-gt6uqfrl 100 63 anaerobe anaerobe NN cord-319448-gt6uqfrl 100 64 , , , cord-319448-gt6uqfrl 100 65 aerobe aerobe NNS cord-319448-gt6uqfrl 100 66 or or CC cord-319448-gt6uqfrl 100 67 facultative facultative JJ cord-319448-gt6uqfrl 100 68 microorganism microorganism NN cord-319448-gt6uqfrl 100 69 , , , cord-319448-gt6uqfrl 100 70 or or CC cord-319448-gt6uqfrl 100 71 its -PRON- PRP$ cord-319448-gt6uqfrl 100 72 appearance appearance NN cord-319448-gt6uqfrl 100 73 under under IN cord-319448-gt6uqfrl 100 74 Gramstain Gramstain NNP cord-319448-gt6uqfrl 100 75 ) ) -RRB- cord-319448-gt6uqfrl 100 76 . . . cord-319448-gt6uqfrl 101 1 These these DT cord-319448-gt6uqfrl 101 2 classifications classification NNS cord-319448-gt6uqfrl 101 3 are be VBP cord-319448-gt6uqfrl 101 4 confusing confusing JJ cord-319448-gt6uqfrl 101 5 , , , cord-319448-gt6uqfrl 101 6 because because IN cord-319448-gt6uqfrl 101 7 , , , cord-319448-gt6uqfrl 101 8 in in IN cord-319448-gt6uqfrl 101 9 addition addition NN cord-319448-gt6uqfrl 101 10 to to IN cord-319448-gt6uqfrl 101 11 being be VBG cord-319448-gt6uqfrl 101 12 problematic problematic JJ cord-319448-gt6uqfrl 101 13 and and CC cord-319448-gt6uqfrl 101 14 often often RB cord-319448-gt6uqfrl 101 15 inadequate inadequate JJ cord-319448-gt6uqfrl 101 16 , , , cord-319448-gt6uqfrl 101 17 they -PRON- PRP cord-319448-gt6uqfrl 101 18 are be VBP cord-319448-gt6uqfrl 101 19 also also RB cord-319448-gt6uqfrl 101 20 overlapping overlap VBG cord-319448-gt6uqfrl 101 21 . . . cord-319448-gt6uqfrl 102 1 Phylogenetic phylogenetic JJ cord-319448-gt6uqfrl 102 2 groupings grouping NNS cord-319448-gt6uqfrl 102 3 are be VBP cord-319448-gt6uqfrl 102 4 not not RB cord-319448-gt6uqfrl 102 5 very very RB cord-319448-gt6uqfrl 102 6 useful useful JJ cord-319448-gt6uqfrl 102 7 for for IN cord-319448-gt6uqfrl 102 8 pathogen pathogen NN cord-319448-gt6uqfrl 102 9 classification classification NN cord-319448-gt6uqfrl 102 10 because because IN cord-319448-gt6uqfrl 102 11 most most JJS cord-319448-gt6uqfrl 102 12 of of IN cord-319448-gt6uqfrl 102 13 the the DT cord-319448-gt6uqfrl 102 14 members member NNS cord-319448-gt6uqfrl 102 15 of of IN cord-319448-gt6uqfrl 102 16 any any DT cord-319448-gt6uqfrl 102 17 group group NN cord-319448-gt6uqfrl 102 18 are be VBP cord-319448-gt6uqfrl 102 19 not not RB cord-319448-gt6uqfrl 102 20 pathogenic pathogenic JJ cord-319448-gt6uqfrl 102 21 in in IN cord-319448-gt6uqfrl 102 22 a a DT cord-319448-gt6uqfrl 102 23 host host NN cord-319448-gt6uqfrl 102 24 . . . cord-319448-gt6uqfrl 103 1 For for IN cord-319448-gt6uqfrl 103 2 example example NN cord-319448-gt6uqfrl 103 3 , , , cord-319448-gt6uqfrl 103 4 of of IN cord-319448-gt6uqfrl 103 5 the the DT cord-319448-gt6uqfrl 103 6 more more JJR cord-319448-gt6uqfrl 103 7 than than IN cord-319448-gt6uqfrl 103 8 150,000 150,000 CD cord-319448-gt6uqfrl 103 9 fungal fungal JJ cord-319448-gt6uqfrl 103 10 species specie NNS cord-319448-gt6uqfrl 103 11 , , , cord-319448-gt6uqfrl 103 12 only only RB cord-319448-gt6uqfrl 103 13 about about IN cord-319448-gt6uqfrl 103 14 150 150 CD cord-319448-gt6uqfrl 103 15 are be VBP cord-319448-gt6uqfrl 103 16 pathogenic pathogenic JJ cord-319448-gt6uqfrl 103 17 for for IN cord-319448-gt6uqfrl 103 18 humans human NNS cord-319448-gt6uqfrl 103 19 , , , cord-319448-gt6uqfrl 103 20 and and CC cord-319448-gt6uqfrl 103 21 these these DT cord-319448-gt6uqfrl 103 22 are be VBP cord-319448-gt6uqfrl 103 23 often often RB cord-319448-gt6uqfrl 103 24 genetically genetically RB cord-319448-gt6uqfrl 103 25 distant distant JJ cord-319448-gt6uqfrl 103 26 from from IN cord-319448-gt6uqfrl 103 27 each each DT cord-319448-gt6uqfrl 103 28 other other JJ cord-319448-gt6uqfrl 103 29 . . . cord-319448-gt6uqfrl 104 1 Phylogenetic phylogenetic JJ cord-319448-gt6uqfrl 104 2 classifications classification NNS cord-319448-gt6uqfrl 104 3 are be VBP cord-319448-gt6uqfrl 104 4 also also RB cord-319448-gt6uqfrl 104 5 subject subject JJ cord-319448-gt6uqfrl 104 6 to to IN cord-319448-gt6uqfrl 104 7 change change NN cord-319448-gt6uqfrl 104 8 , , , cord-319448-gt6uqfrl 104 9 • • XX cord-319448-gt6uqfrl 105 1 The the DT cord-319448-gt6uqfrl 105 2 phenotype phenotype NN cord-319448-gt6uqfrl 105 3 or or CC cord-319448-gt6uqfrl 105 4 property property NN cord-319448-gt6uqfrl 105 5 that that WDT cord-319448-gt6uqfrl 105 6 is be VBZ cord-319448-gt6uqfrl 105 7 under under IN cord-319448-gt6uqfrl 105 8 investigation investigation NN cord-319448-gt6uqfrl 105 9 should should MD cord-319448-gt6uqfrl 105 10 be be VB cord-319448-gt6uqfrl 105 11 associated associate VBN cord-319448-gt6uqfrl 105 12 with with IN cord-319448-gt6uqfrl 105 13 pathogenic pathogenic JJ cord-319448-gt6uqfrl 105 14 members member NNS cord-319448-gt6uqfrl 105 15 of of IN cord-319448-gt6uqfrl 105 16 a a DT cord-319448-gt6uqfrl 105 17 genus genus NN cord-319448-gt6uqfrl 105 18 or or CC cord-319448-gt6uqfrl 105 19 pathogenic pathogenic JJ cord-319448-gt6uqfrl 105 20 strains strain NNS cord-319448-gt6uqfrl 105 21 of of IN cord-319448-gt6uqfrl 105 22 a a DT cord-319448-gt6uqfrl 105 23 species specie NNS cord-319448-gt6uqfrl 105 24 . . . cord-319448-gt6uqfrl 106 1 • • NNP cord-319448-gt6uqfrl 107 1 Specific specific JJ cord-319448-gt6uqfrl 107 2 inactivation inactivation NN cord-319448-gt6uqfrl 107 3 of of IN cord-319448-gt6uqfrl 107 4 the the DT cord-319448-gt6uqfrl 107 5 gene gene NN cord-319448-gt6uqfrl 107 6 or or CC cord-319448-gt6uqfrl 107 7 genes gene NNS cord-319448-gt6uqfrl 107 8 that that WDT cord-319448-gt6uqfrl 107 9 are be VBP cord-319448-gt6uqfrl 107 10 associated associate VBN cord-319448-gt6uqfrl 107 11 with with IN cord-319448-gt6uqfrl 107 12 the the DT cord-319448-gt6uqfrl 107 13 suspected suspect VBN cord-319448-gt6uqfrl 107 14 virulence virulence NN cord-319448-gt6uqfrl 107 15 trait trait NN cord-319448-gt6uqfrl 107 16 should should MD cord-319448-gt6uqfrl 107 17 lead lead VB cord-319448-gt6uqfrl 107 18 to to IN cord-319448-gt6uqfrl 107 19 a a DT cord-319448-gt6uqfrl 107 20 measurable measurable JJ cord-319448-gt6uqfrl 107 21 loss loss NN cord-319448-gt6uqfrl 107 22 in in IN cord-319448-gt6uqfrl 107 23 pathogenicity pathogenicity NN cord-319448-gt6uqfrl 107 24 or or CC cord-319448-gt6uqfrl 107 25 virulence virulence NN cord-319448-gt6uqfrl 107 26 . . . cord-319448-gt6uqfrl 108 1 • • NNP cord-319448-gt6uqfrl 108 2 Reversion Reversion NNP cord-319448-gt6uqfrl 108 3 or or CC cord-319448-gt6uqfrl 108 4 allelic allelic JJ cord-319448-gt6uqfrl 108 5 replacement replacement NN cord-319448-gt6uqfrl 108 6 of of IN cord-319448-gt6uqfrl 108 7 the the DT cord-319448-gt6uqfrl 108 8 mutated mutate VBN cord-319448-gt6uqfrl 108 9 gene gene NN cord-319448-gt6uqfrl 108 10 should should MD cord-319448-gt6uqfrl 108 11 lead lead VB cord-319448-gt6uqfrl 108 12 to to IN cord-319448-gt6uqfrl 108 13 restoration restoration NN cord-319448-gt6uqfrl 108 14 of of IN cord-319448-gt6uqfrl 108 15 pathogenicity pathogenicity NN cord-319448-gt6uqfrl 108 16 . . . cord-319448-gt6uqfrl 109 1 downwards downwards RB cord-319448-gt6uqfrl 109 2 and and CC cord-319448-gt6uqfrl 109 3 to to IN cord-319448-gt6uqfrl 109 4 the the DT cord-319448-gt6uqfrl 109 5 left left NN cord-319448-gt6uqfrl 109 6 , , , cord-319448-gt6uqfrl 109 7 deteriorations deterioration NNS cord-319448-gt6uqfrl 109 8 in in IN cord-319448-gt6uqfrl 109 9 host host NN cord-319448-gt6uqfrl 109 10 immunity immunity NN cord-319448-gt6uqfrl 109 11 can can MD cord-319448-gt6uqfrl 109 12 shift shift VB cord-319448-gt6uqfrl 109 13 them -PRON- PRP cord-319448-gt6uqfrl 109 14 upwards upwards RB cord-319448-gt6uqfrl 109 15 , , , cord-319448-gt6uqfrl 109 16 and and CC cord-319448-gt6uqfrl 109 17 exuberant exuberant JJ cord-319448-gt6uqfrl 109 18 immune immune JJ cord-319448-gt6uqfrl 109 19 responses response NNS cord-319448-gt6uqfrl 109 20 , , , cord-319448-gt6uqfrl 109 21 such such JJ cord-319448-gt6uqfrl 109 22 as as IN cord-319448-gt6uqfrl 109 23 those those DT cord-319448-gt6uqfrl 109 24 elicited elicit VBN cord-319448-gt6uqfrl 109 25 by by IN cord-319448-gt6uqfrl 109 26 some some DT cord-319448-gt6uqfrl 109 27 vaccines vaccine NNS cord-319448-gt6uqfrl 109 28 , , , cord-319448-gt6uqfrl 109 29 can can MD cord-319448-gt6uqfrl 109 30 shift shift VB cord-319448-gt6uqfrl 109 31 them -PRON- PRP cord-319448-gt6uqfrl 109 32 upwards upwards RB cord-319448-gt6uqfrl 109 33 and and CC cord-319448-gt6uqfrl 109 34 to to IN cord-319448-gt6uqfrl 109 35 the the DT cord-319448-gt6uqfrl 109 36 right right NN cord-319448-gt6uqfrl 109 37 . . . cord-319448-gt6uqfrl 110 1 Finally finally RB cord-319448-gt6uqfrl 110 2 , , , cord-319448-gt6uqfrl 110 3 the the DT cord-319448-gt6uqfrl 110 4 damage damage NN cord-319448-gt6uqfrl 110 5 - - HYPH cord-319448-gt6uqfrl 110 6 response response NN cord-319448-gt6uqfrl 110 7 curves curve NNS cord-319448-gt6uqfrl 110 8 can can MD cord-319448-gt6uqfrl 110 9 help help VB cord-319448-gt6uqfrl 110 10 in in IN cord-319448-gt6uqfrl 110 11 the the DT cord-319448-gt6uqfrl 110 12 classification classification NN cord-319448-gt6uqfrl 110 13 of of IN cord-319448-gt6uqfrl 110 14 new new JJ cord-319448-gt6uqfrl 110 15 pathogens pathogen NNS cord-319448-gt6uqfrl 110 16 and and CC cord-319448-gt6uqfrl 110 17 diseases disease NNS cord-319448-gt6uqfrl 110 18 . . . cord-319448-gt6uqfrl 111 1 For for IN cord-319448-gt6uqfrl 111 2 example example NN cord-319448-gt6uqfrl 111 3 , , , cord-319448-gt6uqfrl 111 4 based base VBN cord-319448-gt6uqfrl 111 5 on on IN cord-319448-gt6uqfrl 111 6 the the DT cord-319448-gt6uqfrl 111 7 available available JJ cord-319448-gt6uqfrl 111 8 information information NN cord-319448-gt6uqfrl 111 9 , , , cord-319448-gt6uqfrl 111 10 the the DT cord-319448-gt6uqfrl 111 11 new new JJ cord-319448-gt6uqfrl 111 12 coronavirus coronavirus NN cord-319448-gt6uqfrl 111 13 associated associate VBN cord-319448-gt6uqfrl 111 14 with with IN cord-319448-gt6uqfrl 111 15 severe severe JJ cord-319448-gt6uqfrl 111 16 acute acute JJ cord-319448-gt6uqfrl 111 17 respiratory respiratory JJ cord-319448-gt6uqfrl 111 18 syndrome syndrome NN cord-319448-gt6uqfrl 111 19 ( ( -LRB- cord-319448-gt6uqfrl 111 20 SARS SARS NNP cord-319448-gt6uqfrl 111 21 ) ) -RRB- cord-319448-gt6uqfrl 111 22 21 21 CD cord-319448-gt6uqfrl 111 23 could could MD cord-319448-gt6uqfrl 111 24 be be VB cord-319448-gt6uqfrl 111 25 classified classify VBN cord-319448-gt6uqfrl 111 26 as as IN cord-319448-gt6uqfrl 111 27 a a DT cord-319448-gt6uqfrl 111 28 Class Class NNP cord-319448-gt6uqfrl 111 29 3- 3- NNP cord-319448-gt6uqfrl 111 30 , , , cord-319448-gt6uqfrl 111 31 4- 4- CD cord-319448-gt6uqfrl 111 32 , , , cord-319448-gt6uqfrl 111 33 5-or 5-or CD cord-319448-gt6uqfrl 111 34 6-like 6-like CD cord-319448-gt6uqfrl 111 35 pathogen pathogen NN cord-319448-gt6uqfrl 111 36 , , , cord-319448-gt6uqfrl 111 37 depending depend VBG cord-319448-gt6uqfrl 111 38 on on IN cord-319448-gt6uqfrl 111 39 the the DT cord-319448-gt6uqfrl 111 40 information information NN cord-319448-gt6uqfrl 111 41 that that WDT cord-319448-gt6uqfrl 111 42 is be VBZ cord-319448-gt6uqfrl 111 43 obtained obtain VBN cord-319448-gt6uqfrl 111 44 from from IN cord-319448-gt6uqfrl 111 45 subsequent subsequent JJ cord-319448-gt6uqfrl 111 46 studies study NNS cord-319448-gt6uqfrl 111 47 . . . cord-319448-gt6uqfrl 112 1 Pathogens pathogen NNS cord-319448-gt6uqfrl 112 2 in in IN cord-319448-gt6uqfrl 112 3 these these DT cord-319448-gt6uqfrl 112 4 classes class NNS cord-319448-gt6uqfrl 112 5 all all DT cord-319448-gt6uqfrl 112 6 cause cause VBP cord-319448-gt6uqfrl 112 7 host host NN cord-319448-gt6uqfrl 112 8 damage damage NN cord-319448-gt6uqfrl 112 9 in in IN cord-319448-gt6uqfrl 112 10 the the DT cord-319448-gt6uqfrl 112 11 setting setting NN cord-319448-gt6uqfrl 112 12 of of IN cord-319448-gt6uqfrl 112 13 strong strong JJ cord-319448-gt6uqfrl 112 14 immune immune JJ cord-319448-gt6uqfrl 112 15 responses response NNS cord-319448-gt6uqfrl 112 16 , , , cord-319448-gt6uqfrl 112 17 and and CC cord-319448-gt6uqfrl 112 18 SARS SARS NNP cord-319448-gt6uqfrl 112 19 has have VBZ cord-319448-gt6uqfrl 112 20 been be VBN cord-319448-gt6uqfrl 112 21 associated associate VBN cord-319448-gt6uqfrl 112 22 with with IN cord-319448-gt6uqfrl 112 23 lung lung NN cord-319448-gt6uqfrl 112 24 damage damage NN cord-319448-gt6uqfrl 112 25 in in IN cord-319448-gt6uqfrl 112 26 the the DT cord-319448-gt6uqfrl 112 27 setting setting NN cord-319448-gt6uqfrl 112 28 of of IN cord-319448-gt6uqfrl 112 29 apparently apparently RB cord-319448-gt6uqfrl 112 30 robust robust JJ cord-319448-gt6uqfrl 112 31 immune immune JJ cord-319448-gt6uqfrl 112 32 responses response NNS cord-319448-gt6uqfrl 112 33 . . . cord-319448-gt6uqfrl 113 1 Indeed indeed RB cord-319448-gt6uqfrl 113 2 , , , cord-319448-gt6uqfrl 113 3 the the DT cord-319448-gt6uqfrl 113 4 proposed propose VBN cord-319448-gt6uqfrl 113 5 system system NN cord-319448-gt6uqfrl 113 6 is be VBZ cord-319448-gt6uqfrl 113 7 flexible flexible JJ cord-319448-gt6uqfrl 113 8 and and CC cord-319448-gt6uqfrl 113 9 allows allow VBZ cord-319448-gt6uqfrl 113 10 pathogenic pathogenic JJ cord-319448-gt6uqfrl 113 11 microorganisms microorganism NNS cord-319448-gt6uqfrl 113 12 to to TO cord-319448-gt6uqfrl 113 13 be be VB cord-319448-gt6uqfrl 113 14 regrouped regroup VBN cord-319448-gt6uqfrl 113 15 as as IN cord-319448-gt6uqfrl 113 16 new new JJ cord-319448-gt6uqfrl 113 17 information information NN cord-319448-gt6uqfrl 113 18 becomes become VBZ cord-319448-gt6uqfrl 113 19 available available JJ cord-319448-gt6uqfrl 113 20 . . . cord-319448-gt6uqfrl 114 1 For for IN cord-319448-gt6uqfrl 114 2 example example NN cord-319448-gt6uqfrl 114 3 , , , cord-319448-gt6uqfrl 114 4 Saccharomyces Saccharomyces NNP cord-319448-gt6uqfrl 114 5 cerevisiae cerevisiae NNS cord-319448-gt6uqfrl 114 6 ( ( -LRB- cord-319448-gt6uqfrl 114 7 bakers baker NNS cord-319448-gt6uqfrl 114 8 ' ' POS cord-319448-gt6uqfrl 114 9 yeast yeast NN cord-319448-gt6uqfrl 114 10 ) ) -RRB- cord-319448-gt6uqfrl 114 11 was be VBD cord-319448-gt6uqfrl 114 12 considered consider VBN cord-319448-gt6uqfrl 114 13 to to TO cord-319448-gt6uqfrl 114 14 be be VB cord-319448-gt6uqfrl 114 15 non non JJ cord-319448-gt6uqfrl 114 16 - - JJ cord-319448-gt6uqfrl 114 17 pathogenic pathogenic JJ cord-319448-gt6uqfrl 114 18 until until IN cord-319448-gt6uqfrl 114 19 it -PRON- PRP cord-319448-gt6uqfrl 114 20 was be VBD cord-319448-gt6uqfrl 114 21 associated associate VBN cord-319448-gt6uqfrl 114 22 with with IN cord-319448-gt6uqfrl 114 23 disease disease NN cord-319448-gt6uqfrl 114 24 in in IN cord-319448-gt6uqfrl 114 25 certain certain JJ cord-319448-gt6uqfrl 114 26 patients patient NNS cord-319448-gt6uqfrl 114 27 with with IN cord-319448-gt6uqfrl 114 28 severe severe JJ cord-319448-gt6uqfrl 114 29 immune immune JJ cord-319448-gt6uqfrl 114 30 impairment impairment NN cord-319448-gt6uqfrl 114 31 22 22 CD cord-319448-gt6uqfrl 114 32 , , , cord-319448-gt6uqfrl 114 33 which which WDT cord-319448-gt6uqfrl 114 34 would would MD cord-319448-gt6uqfrl 114 35 have have VB cord-319448-gt6uqfrl 114 36 led lead VBN cord-319448-gt6uqfrl 114 37 it -PRON- PRP cord-319448-gt6uqfrl 114 38 to to TO cord-319448-gt6uqfrl 114 39 be be VB cord-319448-gt6uqfrl 114 40 categorized categorize VBN cord-319448-gt6uqfrl 114 41 as as IN cord-319448-gt6uqfrl 114 42 a a DT cord-319448-gt6uqfrl 114 43 Class class NN cord-319448-gt6uqfrl 114 44 1 1 CD cord-319448-gt6uqfrl 114 45 pathogen pathogen NN cord-319448-gt6uqfrl 114 46 . . . cord-319448-gt6uqfrl 115 1 However however RB cord-319448-gt6uqfrl 115 2 , , , cord-319448-gt6uqfrl 115 3 recent recent JJ cord-319448-gt6uqfrl 115 4 evidence evidence NN cord-319448-gt6uqfrl 115 5 indicates indicate VBZ cord-319448-gt6uqfrl 115 6 that that IN cord-319448-gt6uqfrl 115 7 certain certain JJ cord-319448-gt6uqfrl 115 8 mutations mutation NNS cord-319448-gt6uqfrl 115 9 in in IN cord-319448-gt6uqfrl 115 10 S. S. NNP cord-319448-gt6uqfrl 115 11 cerevisiae cerevisiae NNS cord-319448-gt6uqfrl 115 12 increase increase VB cord-319448-gt6uqfrl 115 13 its -PRON- PRP$ cord-319448-gt6uqfrl 115 14 virulence virulence NN cord-319448-gt6uqfrl 115 15 in in IN cord-319448-gt6uqfrl 115 16 normal normal JJ cord-319448-gt6uqfrl 115 17 mice mouse NNS cord-319448-gt6uqfrl 115 18 by by IN cord-319448-gt6uqfrl 115 19 altering alter VBG cord-319448-gt6uqfrl 115 20 its -PRON- PRP$ cord-319448-gt6uqfrl 115 21 surface surface NN cord-319448-gt6uqfrl 115 22 properties property NNS cord-319448-gt6uqfrl 115 23 to to TO cord-319448-gt6uqfrl 115 24 elicit elicit VB cord-319448-gt6uqfrl 115 25 a a DT cord-319448-gt6uqfrl 115 26 potent potent JJ cord-319448-gt6uqfrl 115 27 pro pro JJ cord-319448-gt6uqfrl 115 28 - - JJ cord-319448-gt6uqfrl 115 29 inflammatory inflammatory JJ cord-319448-gt6uqfrl 115 30 response response NN cord-319448-gt6uqfrl 115 31 that that WDT cord-319448-gt6uqfrl 115 32 damages damage VBZ cord-319448-gt6uqfrl 115 33 tissues tissue NNS cord-319448-gt6uqfrl 115 34 and and CC cord-319448-gt6uqfrl 115 35 causes cause VBZ cord-319448-gt6uqfrl 115 36 disease disease NN cord-319448-gt6uqfrl 115 37 23 23 CD cord-319448-gt6uqfrl 115 38 . . . cord-319448-gt6uqfrl 116 1 Consequently consequently RB cord-319448-gt6uqfrl 116 2 , , , cord-319448-gt6uqfrl 116 3 it -PRON- PRP cord-319448-gt6uqfrl 116 4 might may MD cord-319448-gt6uqfrl 116 5 be be VB cord-319448-gt6uqfrl 116 6 more more RBR cord-319448-gt6uqfrl 116 7 appropriate appropriate JJ cord-319448-gt6uqfrl 116 8 to to TO cord-319448-gt6uqfrl 116 9 characterize characterize VB cord-319448-gt6uqfrl 116 10 S. S. NNP cord-319448-gt6uqfrl 116 11 cerevisiae cerevisiae NNS cord-319448-gt6uqfrl 116 12 as as IN cord-319448-gt6uqfrl 116 13 a a DT cord-319448-gt6uqfrl 116 14 Class class NN cord-319448-gt6uqfrl 116 15 2 2 CD cord-319448-gt6uqfrl 116 16 or or CC cord-319448-gt6uqfrl 116 17 3 3 CD cord-319448-gt6uqfrl 116 18 pathogen pathogen NN cord-319448-gt6uqfrl 116 19 in in IN cord-319448-gt6uqfrl 116 20 mice mouse NNS cord-319448-gt6uqfrl 116 21 . . . cord-319448-gt6uqfrl 117 1 Microorganism microorganism NN cord-319448-gt6uqfrl 117 2 - - HYPH cord-319448-gt6uqfrl 117 3 mediated mediate VBN cord-319448-gt6uqfrl 117 4 damage damage NN cord-319448-gt6uqfrl 117 5 in in IN cord-319448-gt6uqfrl 117 6 a a DT cord-319448-gt6uqfrl 117 7 host host NN cord-319448-gt6uqfrl 117 8 can can MD cord-319448-gt6uqfrl 117 9 result result VB cord-319448-gt6uqfrl 117 10 from from IN cord-319448-gt6uqfrl 117 11 a a DT cord-319448-gt6uqfrl 117 12 variety variety NN cord-319448-gt6uqfrl 117 13 of of IN cord-319448-gt6uqfrl 117 14 mechanisms mechanism NNS cord-319448-gt6uqfrl 117 15 , , , cord-319448-gt6uqfrl 117 16 ranging range VBG cord-319448-gt6uqfrl 117 17 from from IN cord-319448-gt6uqfrl 117 18 replication replication NN cord-319448-gt6uqfrl 117 19 of of IN cord-319448-gt6uqfrl 117 20 the the DT cord-319448-gt6uqfrl 117 21 pathogen pathogen NN cord-319448-gt6uqfrl 117 22 , , , cord-319448-gt6uqfrl 117 23 the the DT cord-319448-gt6uqfrl 117 24 production production NN cord-319448-gt6uqfrl 117 25 of of IN cord-319448-gt6uqfrl 117 26 toxic toxic JJ cord-319448-gt6uqfrl 117 27 substances substance NNS cord-319448-gt6uqfrl 117 28 and and CC cord-319448-gt6uqfrl 117 29 subversion subversion NN cord-319448-gt6uqfrl 117 30 of of IN cord-319448-gt6uqfrl 117 31 the the DT cord-319448-gt6uqfrl 117 32 normal normal JJ cord-319448-gt6uqfrl 117 33 host host NN cord-319448-gt6uqfrl 117 34 homeostatic homeostatic JJ cord-319448-gt6uqfrl 117 35 and/or and/or CC cord-319448-gt6uqfrl 117 36 immune immune JJ cord-319448-gt6uqfrl 117 37 mechanisms mechanism NNS cord-319448-gt6uqfrl 117 38 ( ( -LRB- cord-319448-gt6uqfrl 117 39 ( ( -LRB- cord-319448-gt6uqfrl 117 40 TABLE TABLE NNP cord-319448-gt6uqfrl 117 41 2 2 CD cord-319448-gt6uqfrl 117 42 ) ) -RRB- cord-319448-gt6uqfrl 117 43 . . . cord-319448-gt6uqfrl 118 1 Notably notably RB cord-319448-gt6uqfrl 118 2 , , , cord-319448-gt6uqfrl 118 3 each each DT cord-319448-gt6uqfrl 118 4 also also RB cord-319448-gt6uqfrl 118 5 has have VBZ cord-319448-gt6uqfrl 118 6 a a DT cord-319448-gt6uqfrl 118 7 polysaccharide polysaccharide JJ cord-319448-gt6uqfrl 118 8 capsule capsule NN cord-319448-gt6uqfrl 118 9 that that WDT cord-319448-gt6uqfrl 118 10 is be VBZ cord-319448-gt6uqfrl 118 11 the the DT cord-319448-gt6uqfrl 118 12 key key JJ cord-319448-gt6uqfrl 118 13 determinant determinant NN cord-319448-gt6uqfrl 118 14 of of IN cord-319448-gt6uqfrl 118 15 their -PRON- PRP$ cord-319448-gt6uqfrl 118 16 capacity capacity NN cord-319448-gt6uqfrl 118 17 to to TO cord-319448-gt6uqfrl 118 18 induce induce VB cord-319448-gt6uqfrl 118 19 host host NN cord-319448-gt6uqfrl 118 20 damage damage NN cord-319448-gt6uqfrl 118 21 , , , cord-319448-gt6uqfrl 118 22 and and CC cord-319448-gt6uqfrl 118 23 each each DT cord-319448-gt6uqfrl 118 24 causes cause VBZ cord-319448-gt6uqfrl 118 25 a a DT cord-319448-gt6uqfrl 118 26 similar similar JJ cord-319448-gt6uqfrl 118 27 clinical clinical JJ cord-319448-gt6uqfrl 118 28 syndrome syndrome NN cord-319448-gt6uqfrl 118 29 . . . cord-319448-gt6uqfrl 119 1 P. P. NNP cord-319448-gt6uqfrl 119 2 carinii carinii NN cord-319448-gt6uqfrl 119 3 is be VBZ cord-319448-gt6uqfrl 119 4 a a DT cord-319448-gt6uqfrl 119 5 Class class NN cord-319448-gt6uqfrl 119 6 1 1 CD cord-319448-gt6uqfrl 119 7 pathogen pathogen NN cord-319448-gt6uqfrl 119 8 because because IN cord-319448-gt6uqfrl 119 9 it -PRON- PRP cord-319448-gt6uqfrl 119 10 does do VBZ cord-319448-gt6uqfrl 119 11 not not RB cord-319448-gt6uqfrl 119 12 cause cause VB cord-319448-gt6uqfrl 119 13 disease disease NN cord-319448-gt6uqfrl 119 14 in in IN cord-319448-gt6uqfrl 119 15 hosts host NNS cord-319448-gt6uqfrl 119 16 with with IN cord-319448-gt6uqfrl 119 17 normal normal JJ cord-319448-gt6uqfrl 119 18 immunity immunity NN cord-319448-gt6uqfrl 119 19 , , , cord-319448-gt6uqfrl 119 20 and and CC cord-319448-gt6uqfrl 119 21 Aspergillus aspergillus NN cord-319448-gt6uqfrl 119 22 fumigatus fumigatus NN cord-319448-gt6uqfrl 119 23 is be VBZ cord-319448-gt6uqfrl 119 24 a a DT cord-319448-gt6uqfrl 119 25 Class class NN cord-319448-gt6uqfrl 119 26 4 4 CD cord-319448-gt6uqfrl 119 27 pathogen pathogen NN cord-319448-gt6uqfrl 119 28 because because IN cord-319448-gt6uqfrl 119 29 it -PRON- PRP cord-319448-gt6uqfrl 119 30 causes cause VBZ cord-319448-gt6uqfrl 119 31 disease disease NN cord-319448-gt6uqfrl 119 32 in in IN cord-319448-gt6uqfrl 119 33 individuals individual NNS cord-319448-gt6uqfrl 119 34 with with IN cord-319448-gt6uqfrl 119 35 either either CC cord-319448-gt6uqfrl 119 36 weak weak JJ cord-319448-gt6uqfrl 119 37 or or CC cord-319448-gt6uqfrl 119 38 strong strong JJ cord-319448-gt6uqfrl 119 39 immunity immunity NN cord-319448-gt6uqfrl 119 40 . . . cord-319448-gt6uqfrl 120 1 In in IN cord-319448-gt6uqfrl 120 2 the the DT cord-319448-gt6uqfrl 120 3 case case NN cord-319448-gt6uqfrl 120 4 of of IN cord-319448-gt6uqfrl 120 5 individuals individual NNS cord-319448-gt6uqfrl 120 6 with with IN cord-319448-gt6uqfrl 120 7 strong strong JJ cord-319448-gt6uqfrl 120 8 immunity immunity NN cord-319448-gt6uqfrl 120 9 , , , cord-319448-gt6uqfrl 120 10 disease disease NN cord-319448-gt6uqfrl 120 11 results result VBZ cord-319448-gt6uqfrl 120 12 from from IN cord-319448-gt6uqfrl 120 13 an an DT cord-319448-gt6uqfrl 120 14 exuberant exuberant JJ cord-319448-gt6uqfrl 120 15 response response NN cord-319448-gt6uqfrl 120 16 to to IN cord-319448-gt6uqfrl 120 17 Aspergillus aspergillus NN cord-319448-gt6uqfrl 120 18 antigens antigen NNS cord-319448-gt6uqfrl 120 19 that that WDT cord-319448-gt6uqfrl 120 20 damages damage VBZ cord-319448-gt6uqfrl 120 21 the the DT cord-319448-gt6uqfrl 120 22 host host NN cord-319448-gt6uqfrl 120 23 through through IN cord-319448-gt6uqfrl 120 24 hypersensitivity hypersensitivity NN cord-319448-gt6uqfrl 120 25 reactions reaction NNS cord-319448-gt6uqfrl 120 26 . . . cord-319448-gt6uqfrl 121 1 The the DT cord-319448-gt6uqfrl 121 2 use use NN cord-319448-gt6uqfrl 121 3 of of IN cord-319448-gt6uqfrl 121 4 host host NN cord-319448-gt6uqfrl 121 5 damage damage NN cord-319448-gt6uqfrl 121 6 to to TO cord-319448-gt6uqfrl 121 7 classify classify VB cord-319448-gt6uqfrl 121 8 the the DT cord-319448-gt6uqfrl 121 9 outcome outcome NN cord-319448-gt6uqfrl 121 10 of of IN cord-319448-gt6uqfrl 121 11 a a DT cord-319448-gt6uqfrl 121 12 host host NN cord-319448-gt6uqfrl 121 13 - - HYPH cord-319448-gt6uqfrl 121 14 microorganism microorganism NN cord-319448-gt6uqfrl 121 15 interaction interaction NN cord-319448-gt6uqfrl 121 16 acknowledges acknowledge VBZ cord-319448-gt6uqfrl 121 17 and and CC cord-319448-gt6uqfrl 121 18 accounts account NNS cord-319448-gt6uqfrl 121 19 for for IN cord-319448-gt6uqfrl 121 20 the the DT cord-319448-gt6uqfrl 121 21 contribution contribution NN cord-319448-gt6uqfrl 121 22 of of IN cord-319448-gt6uqfrl 121 23 the the DT cord-319448-gt6uqfrl 121 24 host host NN cord-319448-gt6uqfrl 121 25 immune immune JJ cord-319448-gt6uqfrl 121 26 response response NN cord-319448-gt6uqfrl 121 27 to to IN cord-319448-gt6uqfrl 121 28 microbial microbial JJ cord-319448-gt6uqfrl 121 29 pathogenicity pathogenicity NN cord-319448-gt6uqfrl 121 30 and and CC cord-319448-gt6uqfrl 121 31 virulence virulence NN cord-319448-gt6uqfrl 121 32 . . . cord-319448-gt6uqfrl 122 1 Therefore therefore RB cord-319448-gt6uqfrl 122 2 , , , cord-319448-gt6uqfrl 122 3 the the DT cord-319448-gt6uqfrl 122 4 ' ' `` cord-319448-gt6uqfrl 122 5 damage damage NN cord-319448-gt6uqfrl 122 6 - - HYPH cord-319448-gt6uqfrl 122 7 response response NN cord-319448-gt6uqfrl 122 8 ' ' '' cord-319448-gt6uqfrl 122 9 framework framework NN cord-319448-gt6uqfrl 122 10 can can MD cord-319448-gt6uqfrl 122 11 be be VB cord-319448-gt6uqfrl 122 12 used use VBN cord-319448-gt6uqfrl 122 13 to to TO cord-319448-gt6uqfrl 122 14 characterize characterize VB cord-319448-gt6uqfrl 122 15 host host NN cord-319448-gt6uqfrl 122 16 - - HYPH cord-319448-gt6uqfrl 122 17 microorganism microorganism NN cord-319448-gt6uqfrl 122 18 interactions interaction NNS cord-319448-gt6uqfrl 122 19 that that WDT cord-319448-gt6uqfrl 122 20 are be VBP cord-319448-gt6uqfrl 122 21 either either DT cord-319448-gt6uqfrl 122 22 detrimental detrimental JJ cord-319448-gt6uqfrl 122 23 or or CC cord-319448-gt6uqfrl 122 24 beneficial beneficial JJ cord-319448-gt6uqfrl 122 25 to to IN cord-319448-gt6uqfrl 122 26 the the DT cord-319448-gt6uqfrl 122 27 host host NN cord-319448-gt6uqfrl 122 28 . . . cord-319448-gt6uqfrl 123 1 A a DT cord-319448-gt6uqfrl 123 2 benefit benefit NN cord-319448-gt6uqfrl 123 3 to to IN cord-319448-gt6uqfrl 123 4 the the DT cord-319448-gt6uqfrl 123 5 host host NN cord-319448-gt6uqfrl 123 6 is be VBZ cord-319448-gt6uqfrl 123 7 indicated indicate VBN cord-319448-gt6uqfrl 123 8 by by IN cord-319448-gt6uqfrl 123 9 the the DT cord-319448-gt6uqfrl 123 10 damage damage NN cord-319448-gt6uqfrl 123 11 - - HYPH cord-319448-gt6uqfrl 123 12 response response NN cord-319448-gt6uqfrl 123 13 curve curve NN cord-319448-gt6uqfrl 123 14 extending extend VBG cord-319448-gt6uqfrl 123 15 below below IN cord-319448-gt6uqfrl 123 16 the the DT cord-319448-gt6uqfrl 123 17 x x NN cord-319448-gt6uqfrl 123 18 - - HYPH cord-319448-gt6uqfrl 123 19 axis axis NN cord-319448-gt6uqfrl 123 20 . . . cord-319448-gt6uqfrl 124 1 The the DT cord-319448-gt6uqfrl 124 2 framework framework NN cord-319448-gt6uqfrl 124 3 is be VBZ cord-319448-gt6uqfrl 124 4 a a DT cord-319448-gt6uqfrl 124 5 flexible flexible JJ cord-319448-gt6uqfrl 124 6 system system NN cord-319448-gt6uqfrl 124 7 in in IN cord-319448-gt6uqfrl 124 8 that that IN cord-319448-gt6uqfrl 124 9 it -PRON- PRP cord-319448-gt6uqfrl 124 10 can can MD cord-319448-gt6uqfrl 124 11 accommodate accommodate VB cord-319448-gt6uqfrl 124 12 changes change NNS cord-319448-gt6uqfrl 124 13 in in IN cord-319448-gt6uqfrl 124 14 both both DT cord-319448-gt6uqfrl 124 15 host host NN cord-319448-gt6uqfrl 124 16 and and CC cord-319448-gt6uqfrl 124 17 microorganism microorganism NN cord-319448-gt6uqfrl 124 18 . . . cord-319448-gt6uqfrl 125 1 For for IN cord-319448-gt6uqfrl 125 2 example example NN cord-319448-gt6uqfrl 125 3 , , , cord-319448-gt6uqfrl 125 4 therapeutic therapeutic JJ cord-319448-gt6uqfrl 125 5 interventions intervention NNS cord-319448-gt6uqfrl 125 6 can can MD cord-319448-gt6uqfrl 125 7 shift shift VB cord-319448-gt6uqfrl 125 8 the the DT cord-319448-gt6uqfrl 125 9 damage damage NN cord-319448-gt6uqfrl 125 10 - - HYPH cord-319448-gt6uqfrl 125 11 response response NN cord-319448-gt6uqfrl 125 12 curves curve NNS cord-319448-gt6uqfrl 126 1 The the DT cord-319448-gt6uqfrl 126 2 arrow arrow NN cord-319448-gt6uqfrl 126 3 indicates indicate VBZ cord-319448-gt6uqfrl 126 4 that that IN cord-319448-gt6uqfrl 126 5 the the DT cord-319448-gt6uqfrl 126 6 position position NN cord-319448-gt6uqfrl 126 7 of of IN cord-319448-gt6uqfrl 126 8 the the DT cord-319448-gt6uqfrl 126 9 curve curve NN cord-319448-gt6uqfrl 126 10 is be VBZ cord-319448-gt6uqfrl 126 11 variable variable JJ cord-319448-gt6uqfrl 126 12 , , , cord-319448-gt6uqfrl 126 13 and and CC cord-319448-gt6uqfrl 126 14 depends depend VBZ cord-319448-gt6uqfrl 126 15 on on IN cord-319448-gt6uqfrl 126 16 the the DT cord-319448-gt6uqfrl 126 17 particular particular JJ cord-319448-gt6uqfrl 126 18 host host NN cord-319448-gt6uqfrl 126 19 - - HYPH cord-319448-gt6uqfrl 126 20 microorganism microorganism NN cord-319448-gt6uqfrl 126 21 interaction interaction NN cord-319448-gt6uqfrl 126 22 . . . cord-319448-gt6uqfrl 127 1 The the DT cord-319448-gt6uqfrl 127 2 y y NN cord-319448-gt6uqfrl 127 3 - - HYPH cord-319448-gt6uqfrl 127 4 axis axis NN cord-319448-gt6uqfrl 127 5 denotes denote VBZ cord-319448-gt6uqfrl 127 6 host host NN cord-319448-gt6uqfrl 127 7 damage damage NN cord-319448-gt6uqfrl 127 8 as as IN cord-319448-gt6uqfrl 127 9 a a DT cord-319448-gt6uqfrl 127 10 function function NN cord-319448-gt6uqfrl 127 11 of of IN cord-319448-gt6uqfrl 127 12 the the DT cord-319448-gt6uqfrl 127 13 host host NN cord-319448-gt6uqfrl 127 14 response response NN cord-319448-gt6uqfrl 127 15 . . . cord-319448-gt6uqfrl 128 1 In in IN cord-319448-gt6uqfrl 128 2 this this DT cord-319448-gt6uqfrl 128 3 scheme scheme NN cord-319448-gt6uqfrl 128 4 , , , cord-319448-gt6uqfrl 128 5 host host NN cord-319448-gt6uqfrl 128 6 damage damage NN cord-319448-gt6uqfrl 128 7 can can MD cord-319448-gt6uqfrl 128 8 occur occur VB cord-319448-gt6uqfrl 128 9 throughout throughout IN cord-319448-gt6uqfrl 128 10 the the DT cord-319448-gt6uqfrl 128 11 host host NN cord-319448-gt6uqfrl 128 12 response response NN cord-319448-gt6uqfrl 128 13 , , , cord-319448-gt6uqfrl 128 14 but but CC cord-319448-gt6uqfrl 128 15 is be VBZ cord-319448-gt6uqfrl 128 16 magnified magnify VBN cord-319448-gt6uqfrl 128 17 at at IN cord-319448-gt6uqfrl 128 18 both both DT cord-319448-gt6uqfrl 128 19 extremes extreme NNS cord-319448-gt6uqfrl 128 20 . . . cord-319448-gt6uqfrl 129 1 The the DT cord-319448-gt6uqfrl 129 2 host host NN cord-319448-gt6uqfrl 129 3 response response NN cord-319448-gt6uqfrl 129 4 is be VBZ cord-319448-gt6uqfrl 129 5 represented represent VBN cord-319448-gt6uqfrl 129 6 by by IN cord-319448-gt6uqfrl 129 7 a a DT cord-319448-gt6uqfrl 129 8 continuum continuum NN cord-319448-gt6uqfrl 129 9 from from IN cord-319448-gt6uqfrl 129 10 ' ' `` cord-319448-gt6uqfrl 129 11 weak weak JJ cord-319448-gt6uqfrl 129 12 ' ' '' cord-319448-gt6uqfrl 129 13 to to IN cord-319448-gt6uqfrl 129 14 ' ' `` cord-319448-gt6uqfrl 129 15 strong strong JJ cord-319448-gt6uqfrl 129 16 ' ' '' cord-319448-gt6uqfrl 129 17 . . . cord-319448-gt6uqfrl 129 18 ' ' '' cord-319448-gt6uqfrl 130 1 Weak weak JJ cord-319448-gt6uqfrl 130 2 ' ' '' cord-319448-gt6uqfrl 130 3 and and CC cord-319448-gt6uqfrl 130 4 ' ' `` cord-319448-gt6uqfrl 130 5 strong strong JJ cord-319448-gt6uqfrl 130 6 ' ' '' cord-319448-gt6uqfrl 130 7 are be VBP cord-319448-gt6uqfrl 130 8 terms term NNS cord-319448-gt6uqfrl 130 9 that that WDT cord-319448-gt6uqfrl 130 10 can can MD cord-319448-gt6uqfrl 130 11 encompass encompass VB cord-319448-gt6uqfrl 130 12 both both DT cord-319448-gt6uqfrl 130 13 quantitative quantitative JJ cord-319448-gt6uqfrl 130 14 and and CC cord-319448-gt6uqfrl 130 15 qualitative qualitative JJ cord-319448-gt6uqfrl 130 16 characteristics characteristic NNS cord-319448-gt6uqfrl 130 17 of of IN cord-319448-gt6uqfrl 130 18 the the DT cord-319448-gt6uqfrl 130 19 host host NN cord-319448-gt6uqfrl 130 20 response response NN cord-319448-gt6uqfrl 130 21 and and CC cord-319448-gt6uqfrl 130 22 are be VBP cord-319448-gt6uqfrl 130 23 used use VBN cord-319448-gt6uqfrl 130 24 as as IN cord-319448-gt6uqfrl 130 25 the the DT cord-319448-gt6uqfrl 130 26 best good JJS cord-319448-gt6uqfrl 130 27 available available JJ cord-319448-gt6uqfrl 130 28 terms term NNS cord-319448-gt6uqfrl 130 29 to to TO cord-319448-gt6uqfrl 130 30 denote denote VB cord-319448-gt6uqfrl 130 31 the the DT cord-319448-gt6uqfrl 130 32 spectrum spectrum NN cord-319448-gt6uqfrl 130 33 of of IN cord-319448-gt6uqfrl 130 34 host host NN cord-319448-gt6uqfrl 130 35 response response NN cord-319448-gt6uqfrl 130 36 as as IN cord-319448-gt6uqfrl 130 37 more more RBR cord-319448-gt6uqfrl 130 38 precise precise JJ cord-319448-gt6uqfrl 130 39 terms term NNS cord-319448-gt6uqfrl 130 40 are be VBP cord-319448-gt6uqfrl 130 41 limiting limit VBG cord-319448-gt6uqfrl 130 42 . . . cord-319448-gt6uqfrl 131 1 Weak weak JJ cord-319448-gt6uqfrl 131 2 responses response NNS cord-319448-gt6uqfrl 131 3 are be VBP cord-319448-gt6uqfrl 131 4 those those DT cord-319448-gt6uqfrl 131 5 that that WDT cord-319448-gt6uqfrl 131 6 are be VBP cord-319448-gt6uqfrl 131 7 insufficient insufficient JJ cord-319448-gt6uqfrl 131 8 , , , cord-319448-gt6uqfrl 131 9 poor poor JJ cord-319448-gt6uqfrl 131 10 or or CC cord-319448-gt6uqfrl 131 11 inappropriate inappropriate JJ cord-319448-gt6uqfrl 132 1 -that -that RB cord-319448-gt6uqfrl 132 2 is be VBZ cord-319448-gt6uqfrl 132 3 , , , cord-319448-gt6uqfrl 132 4 they -PRON- PRP cord-319448-gt6uqfrl 132 5 are be VBP cord-319448-gt6uqfrl 132 6 not not RB cord-319448-gt6uqfrl 132 7 strong strong JJ cord-319448-gt6uqfrl 132 8 enough enough RB cord-319448-gt6uqfrl 132 9 to to TO cord-319448-gt6uqfrl 132 10 benefit benefit VB cord-319448-gt6uqfrl 132 11 the the DT cord-319448-gt6uqfrl 132 12 host host NN cord-319448-gt6uqfrl 132 13 . . . cord-319448-gt6uqfrl 133 1 Strong strong JJ cord-319448-gt6uqfrl 133 2 responses response NNS cord-319448-gt6uqfrl 133 3 are be VBP cord-319448-gt6uqfrl 133 4 those those DT cord-319448-gt6uqfrl 133 5 that that WDT cord-319448-gt6uqfrl 133 6 are be VBP cord-319448-gt6uqfrl 133 7 excessive excessive JJ cord-319448-gt6uqfrl 133 8 , , , cord-319448-gt6uqfrl 133 9 overly overly RB cord-319448-gt6uqfrl 133 10 robust robust JJ cord-319448-gt6uqfrl 133 11 or or CC cord-319448-gt6uqfrl 133 12 inappropriate inappropriate JJ cord-319448-gt6uqfrl 133 13 -that -that NN cord-319448-gt6uqfrl 133 14 is be VBZ cord-319448-gt6uqfrl 133 15 , , , cord-319448-gt6uqfrl 133 16 they -PRON- PRP cord-319448-gt6uqfrl 133 17 are be VBP cord-319448-gt6uqfrl 133 18 too too RB cord-319448-gt6uqfrl 133 19 strong strong JJ cord-319448-gt6uqfrl 133 20 and and CC cord-319448-gt6uqfrl 133 21 can can MD cord-319448-gt6uqfrl 133 22 damage damage VB cord-319448-gt6uqfrl 133 23 the the DT cord-319448-gt6uqfrl 133 24 host host NN cord-319448-gt6uqfrl 133 25 . . . cord-319448-gt6uqfrl 134 1 When when WRB cord-319448-gt6uqfrl 134 2 a a DT cord-319448-gt6uqfrl 134 3 threshold threshold NN cord-319448-gt6uqfrl 134 4 amount amount NN cord-319448-gt6uqfrl 134 5 of of IN cord-319448-gt6uqfrl 134 6 damage damage NN cord-319448-gt6uqfrl 134 7 is be VBZ cord-319448-gt6uqfrl 134 8 reached reach VBN cord-319448-gt6uqfrl 134 9 , , , cord-319448-gt6uqfrl 134 10 the the DT cord-319448-gt6uqfrl 134 11 host host NN cord-319448-gt6uqfrl 134 12 can can MD cord-319448-gt6uqfrl 134 13 become become VB cord-319448-gt6uqfrl 134 14 symptomatic symptomatic JJ cord-319448-gt6uqfrl 134 15 and and CC cord-319448-gt6uqfrl 134 16 if if IN cord-319448-gt6uqfrl 134 17 damage damage NN cord-319448-gt6uqfrl 134 18 is be VBZ cord-319448-gt6uqfrl 134 19 severe severe JJ cord-319448-gt6uqfrl 134 20 , , , cord-319448-gt6uqfrl 134 21 death death NN cord-319448-gt6uqfrl 134 22 can can MD cord-319448-gt6uqfrl 134 23 ensue ensue VB cord-319448-gt6uqfrl 134 24 . . . cord-319448-gt6uqfrl 135 1 Green green JJ cord-319448-gt6uqfrl 135 2 , , , cord-319448-gt6uqfrl 135 3 yellow yellow JJ cord-319448-gt6uqfrl 135 4 and and CC cord-319448-gt6uqfrl 135 5 purple purple JJ cord-319448-gt6uqfrl 135 6 represent represent VBP cord-319448-gt6uqfrl 135 7 health health NN cord-319448-gt6uqfrl 135 8 , , , cord-319448-gt6uqfrl 135 9 disease disease NN cord-319448-gt6uqfrl 135 10 and and CC cord-319448-gt6uqfrl 135 11 severe severe JJ cord-319448-gt6uqfrl 135 12 disease disease NN cord-319448-gt6uqfrl 135 13 , , , cord-319448-gt6uqfrl 135 14 respectively respectively RB cord-319448-gt6uqfrl 135 15 . . . cord-319448-gt6uqfrl 136 1 from from IN cord-319448-gt6uqfrl 136 2 the the DT cord-319448-gt6uqfrl 136 3 immune immune JJ cord-319448-gt6uqfrl 136 4 response response NN cord-319448-gt6uqfrl 136 5 of of IN cord-319448-gt6uqfrl 136 6 normal normal JJ cord-319448-gt6uqfrl 136 7 individuals individual NNS cord-319448-gt6uqfrl 136 8 to to IN cord-319448-gt6uqfrl 136 9 these these DT cord-319448-gt6uqfrl 136 10 microorganisms microorganism NNS cord-319448-gt6uqfrl 136 11 . . . cord-319448-gt6uqfrl 137 1 For for IN cord-319448-gt6uqfrl 137 2 example example NN cord-319448-gt6uqfrl 137 3 , , , cord-319448-gt6uqfrl 137 4 the the DT cord-319448-gt6uqfrl 137 5 chemokine chemokine NN cord-319448-gt6uqfrl 137 6 and and CC cord-319448-gt6uqfrl 137 7 cytokine cytokine NN cord-319448-gt6uqfrl 137 8 mediator mediator NN cord-319448-gt6uqfrl 137 9 response response NN cord-319448-gt6uqfrl 137 10 to to IN cord-319448-gt6uqfrl 137 11 S. S. NNP cord-319448-gt6uqfrl 137 12 pneumoniae pneumoniae NN cord-319448-gt6uqfrl 137 13 is be VBZ cord-319448-gt6uqfrl 137 14 responsible responsible JJ cord-319448-gt6uqfrl 137 15 for for IN cord-319448-gt6uqfrl 137 16 the the DT cord-319448-gt6uqfrl 137 17 clinical clinical JJ cord-319448-gt6uqfrl 137 18 manifestations manifestation NNS cord-319448-gt6uqfrl 137 19 of of IN cord-319448-gt6uqfrl 137 20 meningitis meningitis NN cord-319448-gt6uqfrl 137 21 . . . cord-319448-gt6uqfrl 138 1 A a DT cord-319448-gt6uqfrl 138 2 long long RB cord-319448-gt6uqfrl 138 3 - - HYPH cord-319448-gt6uqfrl 138 4 lasting last VBG cord-319448-gt6uqfrl 138 5 inflammatory inflammatory JJ cord-319448-gt6uqfrl 138 6 response response NN cord-319448-gt6uqfrl 138 7 to to IN cord-319448-gt6uqfrl 138 8 microbial microbial JJ cord-319448-gt6uqfrl 138 9 components component NNS cord-319448-gt6uqfrl 138 10 can can MD cord-319448-gt6uqfrl 138 11 result result VB cord-319448-gt6uqfrl 138 12 in in IN cord-319448-gt6uqfrl 138 13 cell cell NN cord-319448-gt6uqfrl 138 14 death death NN cord-319448-gt6uqfrl 138 15 and and CC cord-319448-gt6uqfrl 138 16 the the DT cord-319448-gt6uqfrl 138 17 replacement replacement NN cord-319448-gt6uqfrl 138 18 of of IN cord-319448-gt6uqfrl 138 19 viable viable JJ cord-319448-gt6uqfrl 138 20 cells cell NNS cord-319448-gt6uqfrl 138 21 and and CC cord-319448-gt6uqfrl 138 22 parenchyma parenchyma NN cord-319448-gt6uqfrl 138 23 with with IN cord-319448-gt6uqfrl 138 24 fibrosis fibrosis NN cord-319448-gt6uqfrl 138 25 . . . cord-319448-gt6uqfrl 139 1 Similarly similarly RB cord-319448-gt6uqfrl 139 2 , , , cord-319448-gt6uqfrl 139 3 chronic chronic JJ cord-319448-gt6uqfrl 139 4 inflammation inflammation NN cord-319448-gt6uqfrl 139 5 can can MD cord-319448-gt6uqfrl 139 6 lead lead VB cord-319448-gt6uqfrl 139 7 to to IN cord-319448-gt6uqfrl 139 8 amyloid amyloid NN cord-319448-gt6uqfrl 139 9 production production NN cord-319448-gt6uqfrl 139 10 , , , cord-319448-gt6uqfrl 139 11 as as IN cord-319448-gt6uqfrl 139 12 is be VBZ cord-319448-gt6uqfrl 139 13 observed observe VBN cord-319448-gt6uqfrl 139 14 in in IN cord-319448-gt6uqfrl 139 15 patients patient NNS cord-319448-gt6uqfrl 139 16 who who WP cord-319448-gt6uqfrl 139 17 have have VBP cord-319448-gt6uqfrl 139 18 had have VBN cord-319448-gt6uqfrl 139 19 tuberculosis tuberculosis NN cord-319448-gt6uqfrl 139 20 ( ( -LRB- cord-319448-gt6uqfrl 139 21 TB TB NNP cord-319448-gt6uqfrl 139 22 ) ) -RRB- cord-319448-gt6uqfrl 139 23 , , , cord-319448-gt6uqfrl 139 24 and and CC cord-319448-gt6uqfrl 139 25 antigen antigen NN cord-319448-gt6uqfrl 139 26 - - HYPH cord-319448-gt6uqfrl 139 27 antibody antibody NN cord-319448-gt6uqfrl 139 28 complexes complex NNS cord-319448-gt6uqfrl 139 29 that that WDT cord-319448-gt6uqfrl 139 30 form form VBP cord-319448-gt6uqfrl 139 31 in in IN cord-319448-gt6uqfrl 139 32 the the DT cord-319448-gt6uqfrl 139 33 course course NN cord-319448-gt6uqfrl 139 34 of of IN cord-319448-gt6uqfrl 139 35 the the DT cord-319448-gt6uqfrl 139 36 immune immune JJ cord-319448-gt6uqfrl 139 37 responsesuch responsesuch JJ cord-319448-gt6uqfrl 139 38 as as IN cord-319448-gt6uqfrl 139 39 those those DT cord-319448-gt6uqfrl 139 40 that that WDT cord-319448-gt6uqfrl 139 41 develop develop VBP cord-319448-gt6uqfrl 139 42 in in IN cord-319448-gt6uqfrl 139 43 staphylococcal staphylococcal JJ cord-319448-gt6uqfrl 139 44 endocarditis endocarditis NN cord-319448-gt6uqfrl 139 45 or or CC cord-319448-gt6uqfrl 139 46 rickettsial rickettsial JJ cord-319448-gt6uqfrl 139 47 diseases disease NNS cord-319448-gt6uqfrl 139 48 -can -can -LRB- cord-319448-gt6uqfrl 139 49 form form NN cord-319448-gt6uqfrl 139 50 deposits deposit NNS cord-319448-gt6uqfrl 139 51 in in IN cord-319448-gt6uqfrl 139 52 vascular vascular JJ cord-319448-gt6uqfrl 139 53 tissues tissue NNS cord-319448-gt6uqfrl 139 54 and and CC cord-319448-gt6uqfrl 139 55 other other JJ cord-319448-gt6uqfrl 139 56 organs organ NNS cord-319448-gt6uqfrl 139 57 , , , cord-319448-gt6uqfrl 139 58 which which WDT cord-319448-gt6uqfrl 139 59 trigger trigger VBP cord-319448-gt6uqfrl 139 60 inflammation inflammation NN cord-319448-gt6uqfrl 139 61 , , , cord-319448-gt6uqfrl 139 62 organ organ NN cord-319448-gt6uqfrl 139 63 damage damage NN cord-319448-gt6uqfrl 139 64 and and CC cord-319448-gt6uqfrl 139 65 dysfunction dysfunction NN cord-319448-gt6uqfrl 139 66 . . . cord-319448-gt6uqfrl 140 1 Antigenic antigenic JJ cord-319448-gt6uqfrl 140 2 mimicry mimicry NN cord-319448-gt6uqfrl 140 3 can can MD cord-319448-gt6uqfrl 140 4 evoke evoke VB cord-319448-gt6uqfrl 140 5 immune immune JJ cord-319448-gt6uqfrl 140 6 responses response NNS cord-319448-gt6uqfrl 140 7 that that WDT cord-319448-gt6uqfrl 140 8 destroy destroy VBP cord-319448-gt6uqfrl 140 9 cells cell NNS cord-319448-gt6uqfrl 140 10 and and CC cord-319448-gt6uqfrl 140 11 tissue tissue NN cord-319448-gt6uqfrl 140 12 -as -as NFP cord-319448-gt6uqfrl 140 13 exemplified exemplify VBN cord-319448-gt6uqfrl 140 14 during during IN cord-319448-gt6uqfrl 140 15 the the DT cord-319448-gt6uqfrl 140 16 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 140 17 of of IN cord-319448-gt6uqfrl 140 18 acute acute JJ cord-319448-gt6uqfrl 140 19 rheumatic rheumatic JJ cord-319448-gt6uqfrl 140 20 fever fever NN cord-319448-gt6uqfrl 140 21 and and CC cord-319448-gt6uqfrl 140 22 the the DT cord-319448-gt6uqfrl 140 23 development development NN cord-319448-gt6uqfrl 140 24 of of IN cord-319448-gt6uqfrl 140 25 haemolytic haemolytic JJ cord-319448-gt6uqfrl 140 26 anaemia anaemia NN cord-319448-gt6uqfrl 140 27 in in IN cord-319448-gt6uqfrl 140 28 the the DT cord-319448-gt6uqfrl 140 29 course course NN cord-319448-gt6uqfrl 140 30 of of IN cord-319448-gt6uqfrl 140 31 Mycoplasma Mycoplasma NNP cord-319448-gt6uqfrl 140 32 pneumonia pneumonia NN cord-319448-gt6uqfrl 140 33 . . . cord-319448-gt6uqfrl 141 1 Host host NN cord-319448-gt6uqfrl 141 2 - - HYPH cord-319448-gt6uqfrl 141 3 microorganism microorganism NN cord-319448-gt6uqfrl 141 4 contact contact NN cord-319448-gt6uqfrl 141 5 is be VBZ cord-319448-gt6uqfrl 141 6 followed follow VBN cord-319448-gt6uqfrl 141 7 by by IN cord-319448-gt6uqfrl 141 8 two two CD cord-319448-gt6uqfrl 141 9 main main JJ cord-319448-gt6uqfrl 141 10 outcomes outcome NNS cord-319448-gt6uqfrl 141 11 , , , cord-319448-gt6uqfrl 141 12 namely namely RB cord-319448-gt6uqfrl 141 13 , , , cord-319448-gt6uqfrl 141 14 the the DT cord-319448-gt6uqfrl 141 15 elimination elimination NN cord-319448-gt6uqfrl 141 16 of of IN cord-319448-gt6uqfrl 141 17 the the DT cord-319448-gt6uqfrl 141 18 microorganism microorganism NN cord-319448-gt6uqfrl 141 19 from from IN cord-319448-gt6uqfrl 141 20 the the DT cord-319448-gt6uqfrl 141 21 host host NN cord-319448-gt6uqfrl 141 22 or or CC cord-319448-gt6uqfrl 141 23 infection infection NN cord-319448-gt6uqfrl 141 24 , , , cord-319448-gt6uqfrl 141 25 which which WDT cord-319448-gt6uqfrl 141 26 can can MD cord-319448-gt6uqfrl 141 27 be be VB cord-319448-gt6uqfrl 141 28 defined define VBN cord-319448-gt6uqfrl 141 29 as as IN cord-319448-gt6uqfrl 141 30 the the DT cord-319448-gt6uqfrl 141 31 acquisition acquisition NN cord-319448-gt6uqfrl 141 32 of of IN cord-319448-gt6uqfrl 141 33 a a DT cord-319448-gt6uqfrl 141 34 microorganism microorganism NN cord-319448-gt6uqfrl 141 35 by by IN cord-319448-gt6uqfrl 141 36 a a DT cord-319448-gt6uqfrl 141 37 host host NN cord-319448-gt6uqfrl 141 38 2 2 CD cord-319448-gt6uqfrl 141 39 . . . cord-319448-gt6uqfrl 142 1 Following follow VBG cord-319448-gt6uqfrl 142 2 infection infection NN cord-319448-gt6uqfrl 142 3 by by IN cord-319448-gt6uqfrl 142 4 the the DT cord-319448-gt6uqfrl 142 5 microorganism microorganism NN cord-319448-gt6uqfrl 142 6 , , , cord-319448-gt6uqfrl 142 7 four four CD cord-319448-gt6uqfrl 142 8 main main JJ cord-319448-gt6uqfrl 142 9 outcomes outcome NNS cord-319448-gt6uqfrl 142 10 , , , cord-319448-gt6uqfrl 142 11 or or CC cord-319448-gt6uqfrl 142 12 states state NNS cord-319448-gt6uqfrl 142 13 , , , cord-319448-gt6uqfrl 142 14 are be VBP cord-319448-gt6uqfrl 142 15 possible possible JJ cord-319448-gt6uqfrl 142 16 : : : cord-319448-gt6uqfrl 142 17 commensalism commensalism NN cord-319448-gt6uqfrl 142 18 , , , cord-319448-gt6uqfrl 142 19 COLONIZATION colonization NN cord-319448-gt6uqfrl 142 20 , , , cord-319448-gt6uqfrl 142 21 persistence persistence NN cord-319448-gt6uqfrl 142 22 ( ( -LRB- cord-319448-gt6uqfrl 142 23 or or CC cord-319448-gt6uqfrl 142 24 LATENCY latency JJ cord-319448-gt6uqfrl 142 25 ) ) -RRB- cord-319448-gt6uqfrl 142 26 and and CC cord-319448-gt6uqfrl 142 27 disease disease NN cord-319448-gt6uqfrl 142 28 ( ( -LRB- cord-319448-gt6uqfrl 142 29 FIG fig NN cord-319448-gt6uqfrl 142 30 . . . cord-319448-gt6uqfrl 142 31 3 3 CD cord-319448-gt6uqfrl 142 32 ) ) -RRB- cord-319448-gt6uqfrl 142 33 . . . cord-319448-gt6uqfrl 143 1 These these DT cord-319448-gt6uqfrl 143 2 states state NNS cord-319448-gt6uqfrl 143 3 are be VBP cord-319448-gt6uqfrl 143 4 a a DT cord-319448-gt6uqfrl 143 5 consequence consequence NN cord-319448-gt6uqfrl 143 6 of of IN cord-319448-gt6uqfrl 143 7 the the DT cord-319448-gt6uqfrl 143 8 outcome outcome NN cord-319448-gt6uqfrl 143 9 of of IN cord-319448-gt6uqfrl 143 10 the the DT cord-319448-gt6uqfrl 143 11 amount amount NN cord-319448-gt6uqfrl 143 12 of of IN cord-319448-gt6uqfrl 143 13 host host NN cord-319448-gt6uqfrl 143 14 damage damage NN cord-319448-gt6uqfrl 143 15 that that WDT cord-319448-gt6uqfrl 143 16 results result VBZ cord-319448-gt6uqfrl 143 17 from from IN cord-319448-gt6uqfrl 143 18 hostmicroorganism hostmicroorganism NN cord-319448-gt6uqfrl 143 19 interactions interaction NNS cord-319448-gt6uqfrl 143 20 over over IN cord-319448-gt6uqfrl 143 21 time time NN cord-319448-gt6uqfrl 143 22 , , , cord-319448-gt6uqfrl 143 23 and and CC cord-319448-gt6uqfrl 143 24 are be VBP cord-319448-gt6uqfrl 143 25 generally generally RB cord-319448-gt6uqfrl 143 26 continuous continuous JJ cord-319448-gt6uqfrl 143 27 , , , cord-319448-gt6uqfrl 143 28 such such JJ cord-319448-gt6uqfrl 143 29 that that IN cord-319448-gt6uqfrl 143 30 when when WRB cord-319448-gt6uqfrl 143 31 damage damage NN cord-319448-gt6uqfrl 143 32 exceeds exceed VBZ cord-319448-gt6uqfrl 143 33 a a DT cord-319448-gt6uqfrl 143 34 threshold threshold NN cord-319448-gt6uqfrl 143 35 amount amount NN cord-319448-gt6uqfrl 143 36 , , , cord-319448-gt6uqfrl 143 37 another another DT cord-319448-gt6uqfrl 143 38 state state NN cord-319448-gt6uqfrl 143 39 becomes become VBZ cord-319448-gt6uqfrl 143 40 relevant relevant JJ cord-319448-gt6uqfrl 143 41 5 5 CD cord-319448-gt6uqfrl 143 42 . . . cord-319448-gt6uqfrl 144 1 For for IN cord-319448-gt6uqfrl 144 2 example example NN cord-319448-gt6uqfrl 144 3 , , , cord-319448-gt6uqfrl 144 4 the the DT cord-319448-gt6uqfrl 144 5 state state NN cord-319448-gt6uqfrl 144 6 of of IN cord-319448-gt6uqfrl 144 7 colonization colonization NN cord-319448-gt6uqfrl 144 8 becomes become VBZ cord-319448-gt6uqfrl 144 9 the the DT cord-319448-gt6uqfrl 144 10 state state NN cord-319448-gt6uqfrl 144 11 of of IN cord-319448-gt6uqfrl 144 12 disease disease NN cord-319448-gt6uqfrl 144 13 when when WRB cord-319448-gt6uqfrl 144 14 a a DT cord-319448-gt6uqfrl 144 15 critical critical JJ cord-319448-gt6uqfrl 144 16 amount amount NN cord-319448-gt6uqfrl 144 17 of of IN cord-319448-gt6uqfrl 144 18 host host NN cord-319448-gt6uqfrl 144 19 damage damage NN cord-319448-gt6uqfrl 144 20 has have VBZ cord-319448-gt6uqfrl 144 21 occurred occur VBN cord-319448-gt6uqfrl 144 22 ; ; : cord-319448-gt6uqfrl 144 23 the the DT cord-319448-gt6uqfrl 144 24 state state NN cord-319448-gt6uqfrl 144 25 of of IN cord-319448-gt6uqfrl 144 26 disease disease NN cord-319448-gt6uqfrl 144 27 can can MD cord-319448-gt6uqfrl 144 28 become become VB cord-319448-gt6uqfrl 144 29 the the DT cord-319448-gt6uqfrl 144 30 state state NN cord-319448-gt6uqfrl 144 31 of of IN cord-319448-gt6uqfrl 144 32 latency latency NN cord-319448-gt6uqfrl 144 33 ; ; : cord-319448-gt6uqfrl 144 34 and and CC cord-319448-gt6uqfrl 144 35 the the DT cord-319448-gt6uqfrl 144 36 state state NN cord-319448-gt6uqfrl 144 37 of of IN cord-319448-gt6uqfrl 144 38 latency latency NNP cord-319448-gt6uqfrl 144 39 can can MD cord-319448-gt6uqfrl 144 40 become become VB cord-319448-gt6uqfrl 144 41 the the DT cord-319448-gt6uqfrl 144 42 state state NN cord-319448-gt6uqfrl 144 43 of of IN cord-319448-gt6uqfrl 144 44 disease disease NN cord-319448-gt6uqfrl 144 45 , , , cord-319448-gt6uqfrl 144 46 again again RB cord-319448-gt6uqfrl 144 47 depending depend VBG cord-319448-gt6uqfrl 144 48 on on IN cord-319448-gt6uqfrl 144 49 the the DT cord-319448-gt6uqfrl 144 50 amount amount NN cord-319448-gt6uqfrl 144 51 of of IN cord-319448-gt6uqfrl 144 52 damage damage NN cord-319448-gt6uqfrl 144 53 resulting result VBG cord-319448-gt6uqfrl 144 54 from from IN cord-319448-gt6uqfrl 144 55 the the DT cord-319448-gt6uqfrl 144 56 host host NN cord-319448-gt6uqfrl 144 57 - - HYPH cord-319448-gt6uqfrl 144 58 microorganism microorganism NN cord-319448-gt6uqfrl 144 59 interaction interaction NN cord-319448-gt6uqfrl 144 60 . . . cord-319448-gt6uqfrl 145 1 These these DT cord-319448-gt6uqfrl 145 2 definitions definition NNS cord-319448-gt6uqfrl 145 3 make make VBP cord-319448-gt6uqfrl 145 4 no no DT cord-319448-gt6uqfrl 145 5 assumptions assumption NNS cord-319448-gt6uqfrl 145 6 about about IN cord-319448-gt6uqfrl 145 7 the the DT cord-319448-gt6uqfrl 145 8 length length NN cord-319448-gt6uqfrl 145 9 of of IN cord-319448-gt6uqfrl 145 10 time time NN cord-319448-gt6uqfrl 145 11 that that IN cord-319448-gt6uqfrl 145 12 a a DT cord-319448-gt6uqfrl 145 13 state state NN cord-319448-gt6uqfrl 145 14 predominates predominate VBZ cord-319448-gt6uqfrl 145 15 , , , cord-319448-gt6uqfrl 145 16 but but CC cord-319448-gt6uqfrl 145 17 instead instead RB cord-319448-gt6uqfrl 145 18 indicate indicate VBP cord-319448-gt6uqfrl 145 19 that that IN cord-319448-gt6uqfrl 145 20 as as IN cord-319448-gt6uqfrl 145 21 time time NN cord-319448-gt6uqfrl 145 22 progresses progress VBZ cord-319448-gt6uqfrl 145 23 , , , cord-319448-gt6uqfrl 145 24 different different JJ cord-319448-gt6uqfrl 145 25 outcomes outcome NNS cord-319448-gt6uqfrl 145 26 of of IN cord-319448-gt6uqfrl 145 27 infection infection NN cord-319448-gt6uqfrl 145 28 are be VBP cord-319448-gt6uqfrl 145 29 determined determine VBN cord-319448-gt6uqfrl 145 30 by by IN cord-319448-gt6uqfrl 145 31 the the DT cord-319448-gt6uqfrl 145 32 nature nature NN cord-319448-gt6uqfrl 145 33 and and CC cord-319448-gt6uqfrl 145 34 degree degree NN cord-319448-gt6uqfrl 145 35 of of IN cord-319448-gt6uqfrl 145 36 damage damage NN cord-319448-gt6uqfrl 145 37 that that WDT cord-319448-gt6uqfrl 145 38 results result VBZ cord-319448-gt6uqfrl 145 39 from from IN cord-319448-gt6uqfrl 145 40 the the DT cord-319448-gt6uqfrl 145 41 host host NN cord-319448-gt6uqfrl 145 42 - - HYPH cord-319448-gt6uqfrl 145 43 microorganism microorganism NN cord-319448-gt6uqfrl 145 44 interaction interaction NN cord-319448-gt6uqfrl 145 45 . . . cord-319448-gt6uqfrl 146 1 The the DT cord-319448-gt6uqfrl 146 2 role role NN cord-319448-gt6uqfrl 146 3 of of IN cord-319448-gt6uqfrl 146 4 the the DT cord-319448-gt6uqfrl 146 5 host host NN cord-319448-gt6uqfrl 146 6 response response NN cord-319448-gt6uqfrl 146 7 in in IN cord-319448-gt6uqfrl 146 8 the the DT cord-319448-gt6uqfrl 146 9 outcome outcome NN cord-319448-gt6uqfrl 146 10 of of IN cord-319448-gt6uqfrl 146 11 microbial microbial JJ cord-319448-gt6uqfrl 146 12 infection infection NN cord-319448-gt6uqfrl 146 13 is be VBZ cord-319448-gt6uqfrl 146 14 twofold twofold JJ cord-319448-gt6uqfrl 146 15 . . . cord-319448-gt6uqfrl 147 1 First first RB cord-319448-gt6uqfrl 147 2 , , , cord-319448-gt6uqfrl 147 3 it -PRON- PRP cord-319448-gt6uqfrl 147 4 defines define VBZ cord-319448-gt6uqfrl 147 5 the the DT cord-319448-gt6uqfrl 147 6 threshold threshold NN cord-319448-gt6uqfrl 147 7 that that WDT cord-319448-gt6uqfrl 147 8 distinguishes distinguish VBZ cord-319448-gt6uqfrl 147 9 host host NN cord-319448-gt6uqfrl 147 10 damage damage NN cord-319448-gt6uqfrl 147 11 from from IN cord-319448-gt6uqfrl 147 12 clinical clinical JJ cord-319448-gt6uqfrl 147 13 disease disease NN cord-319448-gt6uqfrl 147 14 , , , cord-319448-gt6uqfrl 147 15 and and CC cord-319448-gt6uqfrl 147 16 second second RB cord-319448-gt6uqfrl 147 17 , , , cord-319448-gt6uqfrl 147 18 it -PRON- PRP cord-319448-gt6uqfrl 147 19 represents represent VBZ cord-319448-gt6uqfrl 147 20 a a DT cord-319448-gt6uqfrl 147 21 factor factor NN cord-319448-gt6uqfrl 147 22 that that WDT cord-319448-gt6uqfrl 147 23 mediates mediate VBZ cord-319448-gt6uqfrl 147 24 transitions transition NNS cord-319448-gt6uqfrl 147 25 between between IN cord-319448-gt6uqfrl 147 26 the the DT cord-319448-gt6uqfrl 147 27 different different JJ cord-319448-gt6uqfrl 147 28 states state NNS cord-319448-gt6uqfrl 147 29 . . . cord-319448-gt6uqfrl 148 1 At at IN cord-319448-gt6uqfrl 148 2 present present NN cord-319448-gt6uqfrl 148 3 , , , cord-319448-gt6uqfrl 148 4 the the DT cord-319448-gt6uqfrl 148 5 inability inability NN cord-319448-gt6uqfrl 148 6 to to TO cord-319448-gt6uqfrl 148 7 precisely precisely RB cord-319448-gt6uqfrl 148 8 define define VB cord-319448-gt6uqfrl 148 9 both both DT cord-319448-gt6uqfrl 148 10 damage damage NN cord-319448-gt6uqfrl 148 11 and and CC cord-319448-gt6uqfrl 148 12 the the DT cord-319448-gt6uqfrl 148 13 threshold threshold NN cord-319448-gt6uqfrl 148 14 between between IN cord-319448-gt6uqfrl 148 15 damage damage NN cord-319448-gt6uqfrl 148 16 and and CC cord-319448-gt6uqfrl 148 17 disease disease NN cord-319448-gt6uqfrl 148 18 , , , cord-319448-gt6uqfrl 148 19 makes make VBZ cord-319448-gt6uqfrl 148 20 the the DT cord-319448-gt6uqfrl 148 21 distinction distinction NN cord-319448-gt6uqfrl 148 22 between between IN cord-319448-gt6uqfrl 148 23 certain certain JJ cord-319448-gt6uqfrl 148 24 states state NNS cord-319448-gt6uqfrl 148 25 difficult difficult JJ cord-319448-gt6uqfrl 148 26 . . . cord-319448-gt6uqfrl 149 1 For for IN cord-319448-gt6uqfrl 149 2 example example NN cord-319448-gt6uqfrl 149 3 , , , cord-319448-gt6uqfrl 149 4 distinguishing distinguish VBG cord-319448-gt6uqfrl 149 5 commensalism commensalism NN cord-319448-gt6uqfrl 149 6 from from IN cord-319448-gt6uqfrl 149 7 colonization colonization NN cord-319448-gt6uqfrl 149 8 is be VBZ cord-319448-gt6uqfrl 149 9 not not RB cord-319448-gt6uqfrl 149 10 possible possible JJ cord-319448-gt6uqfrl 149 11 when when WRB cord-319448-gt6uqfrl 149 12 the the DT cord-319448-gt6uqfrl 149 13 latter latter JJ cord-319448-gt6uqfrl 149 14 is be VBZ cord-319448-gt6uqfrl 149 15 accompanied accompany VBN cord-319448-gt6uqfrl 149 16 by by IN cord-319448-gt6uqfrl 149 17 little little JJ cord-319448-gt6uqfrl 149 18 or or CC cord-319448-gt6uqfrl 149 19 no no DT cord-319448-gt6uqfrl 149 20 damage damage NN cord-319448-gt6uqfrl 149 21 2 2 CD cord-319448-gt6uqfrl 149 22 , , , cord-319448-gt6uqfrl 149 23 5 5 CD cord-319448-gt6uqfrl 149 24 . . . cord-319448-gt6uqfrl 150 1 In in IN cord-319448-gt6uqfrl 150 2 contrast contrast NN cord-319448-gt6uqfrl 150 3 to to IN cord-319448-gt6uqfrl 150 4 microorganism microorganism NN cord-319448-gt6uqfrl 150 5 - - HYPH cord-319448-gt6uqfrl 150 6 based base VBN cord-319448-gt6uqfrl 150 7 classification classification NN cord-319448-gt6uqfrl 150 8 schemes scheme NNS cord-319448-gt6uqfrl 150 9 , , , cord-319448-gt6uqfrl 150 10 the the DT cord-319448-gt6uqfrl 150 11 damage damage NN cord-319448-gt6uqfrl 150 12 - - HYPH cord-319448-gt6uqfrl 150 13 response response NN cord-319448-gt6uqfrl 150 14 framework framework NN cord-319448-gt6uqfrl 150 15 is be VBZ cord-319448-gt6uqfrl 150 16 based base VBN cord-319448-gt6uqfrl 150 17 on on IN cord-319448-gt6uqfrl 150 18 the the DT cord-319448-gt6uqfrl 150 19 concept concept NN cord-319448-gt6uqfrl 150 20 that that IN cord-319448-gt6uqfrl 150 21 the the DT cord-319448-gt6uqfrl 150 22 fundamental fundamental JJ cord-319448-gt6uqfrl 150 23 difference difference NN cord-319448-gt6uqfrl 150 24 between between IN cord-319448-gt6uqfrl 150 25 pathogenic pathogenic JJ cord-319448-gt6uqfrl 150 26 and and CC cord-319448-gt6uqfrl 150 27 non non JJ cord-319448-gt6uqfrl 150 28 - - JJ cord-319448-gt6uqfrl 150 29 pathogenic pathogenic JJ cord-319448-gt6uqfrl 150 30 microorganisms microorganism NNS cord-319448-gt6uqfrl 150 31 is be VBZ cord-319448-gt6uqfrl 150 32 a a DT cord-319448-gt6uqfrl 150 33 function function NN cord-319448-gt6uqfrl 150 34 of of IN cord-319448-gt6uqfrl 150 35 the the DT cord-319448-gt6uqfrl 150 36 host host NN cord-319448-gt6uqfrl 150 37 response response NN cord-319448-gt6uqfrl 150 38 to to IN cord-319448-gt6uqfrl 150 39 the the DT cord-319448-gt6uqfrl 150 40 microorganism microorganism NN cord-319448-gt6uqfrl 150 41 . . . cord-319448-gt6uqfrl 151 1 An an DT cord-319448-gt6uqfrl 151 2 effective effective JJ cord-319448-gt6uqfrl 151 3 immune immune JJ cord-319448-gt6uqfrl 151 4 response response NN cord-319448-gt6uqfrl 151 5 can can MD cord-319448-gt6uqfrl 151 6 abrogate abrogate VB cord-319448-gt6uqfrl 151 7 the the DT cord-319448-gt6uqfrl 151 8 factor factor NN cord-319448-gt6uqfrl 151 9 is be VBZ cord-319448-gt6uqfrl 151 10 entirely entirely RB cord-319448-gt6uqfrl 151 11 responsible responsible JJ cord-319448-gt6uqfrl 151 12 for for IN cord-319448-gt6uqfrl 151 13 host host NN cord-319448-gt6uqfrl 151 14 damage damage NN cord-319448-gt6uqfrl 152 1 -for -for : cord-319448-gt6uqfrl 152 2 example example NN cord-319448-gt6uqfrl 152 3 , , , cord-319448-gt6uqfrl 152 4 a a DT cord-319448-gt6uqfrl 152 5 toxin toxin NN cord-319448-gt6uqfrl 152 6 that that WDT cord-319448-gt6uqfrl 152 7 causes cause VBZ cord-319448-gt6uqfrl 152 8 damage damage NN cord-319448-gt6uqfrl 152 9 irrespective irrespective RB cord-319448-gt6uqfrl 152 10 of of IN cord-319448-gt6uqfrl 152 11 the the DT cord-319448-gt6uqfrl 152 12 host host NN cord-319448-gt6uqfrl 152 13 response response NN cord-319448-gt6uqfrl 152 14 because because IN cord-319448-gt6uqfrl 152 15 toxin toxin NN cord-319448-gt6uqfrl 152 16 action action NN cord-319448-gt6uqfrl 152 17 is be VBZ cord-319448-gt6uqfrl 152 18 so so RB cord-319448-gt6uqfrl 152 19 rapid rapid JJ cord-319448-gt6uqfrl 152 20 and/or and/or CC cord-319448-gt6uqfrl 152 21 the the DT cord-319448-gt6uqfrl 152 22 amount amount NN cord-319448-gt6uqfrl 152 23 of of IN cord-319448-gt6uqfrl 152 24 toxin toxin NN cord-319448-gt6uqfrl 152 25 is be VBZ cord-319448-gt6uqfrl 152 26 insufficient insufficient JJ cord-319448-gt6uqfrl 152 27 to to TO cord-319448-gt6uqfrl 152 28 trigger trigger VB cord-319448-gt6uqfrl 152 29 an an DT cord-319448-gt6uqfrl 152 30 immune immune JJ cord-319448-gt6uqfrl 152 31 response response NN cord-319448-gt6uqfrl 152 32 . . . cord-319448-gt6uqfrl 153 1 Previously previously RB cord-319448-gt6uqfrl 153 2 , , , cord-319448-gt6uqfrl 153 3 we -PRON- PRP cord-319448-gt6uqfrl 153 4 have have VBP cord-319448-gt6uqfrl 153 5 proposed propose VBN cord-319448-gt6uqfrl 153 6 that that DT cord-319448-gt6uqfrl 153 7 toxin toxin NN cord-319448-gt6uqfrl 153 8 - - HYPH cord-319448-gt6uqfrl 153 9 producing produce VBG cord-319448-gt6uqfrl 153 10 microorganisms microorganism NNS cord-319448-gt6uqfrl 153 11 are be VBP cord-319448-gt6uqfrl 153 12 a a DT cord-319448-gt6uqfrl 153 13 variant variant NN cord-319448-gt6uqfrl 153 14 of of IN cord-319448-gt6uqfrl 153 15 Class Class NNP cord-319448-gt6uqfrl 153 16 3 3 CD cord-319448-gt6uqfrl 153 17 where where WRB cord-319448-gt6uqfrl 153 18 the the DT cord-319448-gt6uqfrl 153 19 curve curve NN cord-319448-gt6uqfrl 153 20 is be VBZ cord-319448-gt6uqfrl 153 21 flat flat JJ cord-319448-gt6uqfrl 153 22 at at IN cord-319448-gt6uqfrl 153 23 both both DT cord-319448-gt6uqfrl 153 24 ends end VBZ cord-319448-gt6uqfrl 153 25 1 1 CD cord-319448-gt6uqfrl 153 26 , , , cord-319448-gt6uqfrl 153 27 but but CC cord-319448-gt6uqfrl 153 28 here here RB cord-319448-gt6uqfrl 153 29 we -PRON- PRP cord-319448-gt6uqfrl 153 30 suggest suggest VBP cord-319448-gt6uqfrl 153 31 that that IN cord-319448-gt6uqfrl 153 32 this this DT cord-319448-gt6uqfrl 153 33 type type NN cord-319448-gt6uqfrl 153 34 of of IN cord-319448-gt6uqfrl 153 35 interaction interaction NN cord-319448-gt6uqfrl 153 36 might may MD cord-319448-gt6uqfrl 153 37 be be VB cord-319448-gt6uqfrl 153 38 unique unique JJ cord-319448-gt6uqfrl 153 39 and and CC cord-319448-gt6uqfrl 153 40 warrants warrant VBZ cord-319448-gt6uqfrl 153 41 a a DT cord-319448-gt6uqfrl 153 42 separate separate JJ cord-319448-gt6uqfrl 153 43 panel panel NN cord-319448-gt6uqfrl 153 44 . . . cord-319448-gt6uqfrl 154 1 As as IN cord-319448-gt6uqfrl 154 2 shown show VBN cord-319448-gt6uqfrl 154 3 here here RB cord-319448-gt6uqfrl 154 4 , , , cord-319448-gt6uqfrl 154 5 the the DT cord-319448-gt6uqfrl 154 6 damage damage NN cord-319448-gt6uqfrl 154 7 - - HYPH cord-319448-gt6uqfrl 154 8 response response NN cord-319448-gt6uqfrl 154 9 classification classification NN cord-319448-gt6uqfrl 154 10 scheme scheme NN cord-319448-gt6uqfrl 154 11 is be VBZ cord-319448-gt6uqfrl 154 12 flexible flexible JJ cord-319448-gt6uqfrl 154 13 and and CC cord-319448-gt6uqfrl 154 14 makes make VBZ cord-319448-gt6uqfrl 154 15 it -PRON- PRP cord-319448-gt6uqfrl 154 16 possible possible JJ cord-319448-gt6uqfrl 154 17 to to TO cord-319448-gt6uqfrl 154 18 postulate postulate VB cord-319448-gt6uqfrl 154 19 the the DT cord-319448-gt6uqfrl 154 20 existence existence NN cord-319448-gt6uqfrl 154 21 of of IN cord-319448-gt6uqfrl 154 22 pathogens pathogen NNS cord-319448-gt6uqfrl 154 23 for for IN cord-319448-gt6uqfrl 154 24 which which WDT cord-319448-gt6uqfrl 154 25 there there EX cord-319448-gt6uqfrl 154 26 are be VBP cord-319448-gt6uqfrl 154 27 no no DT cord-319448-gt6uqfrl 154 28 known know VBN cord-319448-gt6uqfrl 154 29 examples example NNS cord-319448-gt6uqfrl 154 30 at at IN cord-319448-gt6uqfrl 154 31 present present NN cord-319448-gt6uqfrl 154 32 . . . cord-319448-gt6uqfrl 155 1 Such such JJ cord-319448-gt6uqfrl 155 2 pathogens pathogen NNS cord-319448-gt6uqfrl 155 3 could could MD cord-319448-gt6uqfrl 155 4 be be VB cord-319448-gt6uqfrl 155 5 recognized recognize VBN cord-319448-gt6uqfrl 155 6 in in IN cord-319448-gt6uqfrl 155 7 the the DT cord-319448-gt6uqfrl 155 8 future future NN cord-319448-gt6uqfrl 155 9 as as IN cord-319448-gt6uqfrl 155 10 ' ' `` cord-319448-gt6uqfrl 155 11 emerging emerge VBG cord-319448-gt6uqfrl 155 12 ' ' '' cord-319448-gt6uqfrl 155 13 pathogens pathogen NNS cord-319448-gt6uqfrl 155 14 as as IN cord-319448-gt6uqfrl 155 15 shown show VBN cord-319448-gt6uqfrl 155 16 in in IN cord-319448-gt6uqfrl 155 17 c c NNP cord-319448-gt6uqfrl 155 18 and and CC cord-319448-gt6uqfrl 155 19 d. d. NNP cord-319448-gt6uqfrl 155 20 c c NNP cord-319448-gt6uqfrl 156 1 | | NNP cord-319448-gt6uqfrl 157 1 The the DT cord-319448-gt6uqfrl 157 2 Class Class NNP cord-319448-gt6uqfrl 157 3 4 4 CD cord-319448-gt6uqfrl 157 4 curve curve NN cord-319448-gt6uqfrl 157 5 is be VBZ cord-319448-gt6uqfrl 157 6 extended extend VBN cord-319448-gt6uqfrl 157 7 below below IN cord-319448-gt6uqfrl 157 8 the the DT cord-319448-gt6uqfrl 157 9 x x NN cord-319448-gt6uqfrl 157 10 - - HYPH cord-319448-gt6uqfrl 157 11 axis axis NN cord-319448-gt6uqfrl 157 12 . . . cord-319448-gt6uqfrl 158 1 Such such PDT cord-319448-gt6uqfrl 158 2 a a DT cord-319448-gt6uqfrl 158 3 theoretical theoretical JJ cord-319448-gt6uqfrl 158 4 microorganism microorganism NN cord-319448-gt6uqfrl 158 5 would would MD cord-319448-gt6uqfrl 158 6 be be VB cord-319448-gt6uqfrl 158 7 a a DT cord-319448-gt6uqfrl 158 8 commensal commensal NN cord-319448-gt6uqfrl 158 9 in in IN cord-319448-gt6uqfrl 158 10 the the DT cord-319448-gt6uqfrl 158 11 setting setting NN cord-319448-gt6uqfrl 158 12 of of IN cord-319448-gt6uqfrl 158 13 intermediate intermediate JJ cord-319448-gt6uqfrl 158 14 host host NN cord-319448-gt6uqfrl 158 15 responses response NNS cord-319448-gt6uqfrl 158 16 , , , cord-319448-gt6uqfrl 158 17 but but CC cord-319448-gt6uqfrl 158 18 pathogenic pathogenic JJ cord-319448-gt6uqfrl 158 19 in in IN cord-319448-gt6uqfrl 158 20 hosts host NNS cord-319448-gt6uqfrl 158 21 with with IN cord-319448-gt6uqfrl 158 22 either either CC cord-319448-gt6uqfrl 158 23 weak weak JJ cord-319448-gt6uqfrl 158 24 or or CC cord-319448-gt6uqfrl 158 25 strong strong JJ cord-319448-gt6uqfrl 158 26 responses response NNS cord-319448-gt6uqfrl 158 27 . . . cord-319448-gt6uqfrl 159 1 d d NNP cord-319448-gt6uqfrl 159 2 | | NNP cord-319448-gt6uqfrl 160 1 The the DT cord-319448-gt6uqfrl 160 2 inverted inverted JJ cord-319448-gt6uqfrl 160 3 parabola parabola NN cord-319448-gt6uqfrl 160 4 represents represent VBZ cord-319448-gt6uqfrl 160 5 a a DT cord-319448-gt6uqfrl 160 6 putative putative JJ cord-319448-gt6uqfrl 160 7 host host NN cord-319448-gt6uqfrl 160 8 - - HYPH cord-319448-gt6uqfrl 160 9 microorganism microorganism NN cord-319448-gt6uqfrl 160 10 interaction interaction NN cord-319448-gt6uqfrl 160 11 that that WDT cord-319448-gt6uqfrl 160 12 induces induce VBZ cord-319448-gt6uqfrl 160 13 damage damage NN cord-319448-gt6uqfrl 160 14 over over IN cord-319448-gt6uqfrl 160 15 a a DT cord-319448-gt6uqfrl 160 16 narrow narrow JJ cord-319448-gt6uqfrl 160 17 and and CC cord-319448-gt6uqfrl 160 18 limited limited JJ cord-319448-gt6uqfrl 160 19 range range NN cord-319448-gt6uqfrl 160 20 of of IN cord-319448-gt6uqfrl 160 21 responses response NNS cord-319448-gt6uqfrl 160 22 , , , cord-319448-gt6uqfrl 160 23 but but CC cord-319448-gt6uqfrl 160 24 not not RB cord-319448-gt6uqfrl 160 25 in in IN cord-319448-gt6uqfrl 160 26 the the DT cord-319448-gt6uqfrl 160 27 presence presence NN cord-319448-gt6uqfrl 160 28 of of IN cord-319448-gt6uqfrl 160 29 either either CC cord-319448-gt6uqfrl 160 30 strong strong JJ cord-319448-gt6uqfrl 160 31 or or CC cord-319448-gt6uqfrl 160 32 weak weak JJ cord-319448-gt6uqfrl 160 33 host host NN cord-319448-gt6uqfrl 160 34 responses response NNS cord-319448-gt6uqfrl 160 35 . . . cord-319448-gt6uqfrl 161 1 One one CD cord-319448-gt6uqfrl 161 2 example example NN cord-319448-gt6uqfrl 161 3 of of IN cord-319448-gt6uqfrl 161 4 such such PDT cord-319448-gt6uqfrl 161 5 a a DT cord-319448-gt6uqfrl 161 6 phenomenon phenomenon NN cord-319448-gt6uqfrl 161 7 would would MD cord-319448-gt6uqfrl 161 8 be be VB cord-319448-gt6uqfrl 161 9 an an DT cord-319448-gt6uqfrl 161 10 antibody antibody NN cord-319448-gt6uqfrl 161 11 response response NN cord-319448-gt6uqfrl 161 12 to to IN cord-319448-gt6uqfrl 161 13 a a DT cord-319448-gt6uqfrl 161 14 hypothetical hypothetical JJ cord-319448-gt6uqfrl 161 15 microorganism microorganism NN cord-319448-gt6uqfrl 161 16 , , , cord-319448-gt6uqfrl 161 17 whereby whereby WRB cord-319448-gt6uqfrl 161 18 host host NN cord-319448-gt6uqfrl 161 19 damage damage NN cord-319448-gt6uqfrl 161 20 is be VBZ cord-319448-gt6uqfrl 161 21 caused cause VBN cord-319448-gt6uqfrl 161 22 by by IN cord-319448-gt6uqfrl 161 23 antigen antigen NN cord-319448-gt6uqfrl 161 24 - - HYPH cord-319448-gt6uqfrl 161 25 antibody antibody NN cord-319448-gt6uqfrl 161 26 complexes complex NNS cord-319448-gt6uqfrl 161 27 . . . cord-319448-gt6uqfrl 162 1 Although although IN cord-319448-gt6uqfrl 162 2 we -PRON- PRP cord-319448-gt6uqfrl 162 3 can can MD cord-319448-gt6uqfrl 162 4 not not RB cord-319448-gt6uqfrl 162 5 think think VB cord-319448-gt6uqfrl 162 6 of of IN cord-319448-gt6uqfrl 162 7 a a DT cord-319448-gt6uqfrl 162 8 specific specific JJ cord-319448-gt6uqfrl 162 9 microorganism microorganism NN cord-319448-gt6uqfrl 162 10 that that WDT cord-319448-gt6uqfrl 162 11 fits fit VBZ cord-319448-gt6uqfrl 162 12 this this DT cord-319448-gt6uqfrl 162 13 description description NN cord-319448-gt6uqfrl 162 14 at at IN cord-319448-gt6uqfrl 162 15 this this DT cord-319448-gt6uqfrl 162 16 time time NN cord-319448-gt6uqfrl 162 17 , , , cord-319448-gt6uqfrl 162 18 examples example NNS cord-319448-gt6uqfrl 162 19 of of IN cord-319448-gt6uqfrl 162 20 this this DT cord-319448-gt6uqfrl 162 21 type type NN cord-319448-gt6uqfrl 162 22 of of IN cord-319448-gt6uqfrl 162 23 host host NN cord-319448-gt6uqfrl 162 24 damage damage NN cord-319448-gt6uqfrl 162 25 are be VBP cord-319448-gt6uqfrl 162 26 the the DT cord-319448-gt6uqfrl 162 27 host host NN cord-319448-gt6uqfrl 162 28 - - HYPH cord-319448-gt6uqfrl 162 29 microorganism microorganism NN cord-319448-gt6uqfrl 162 30 interactions interaction NNS cord-319448-gt6uqfrl 162 31 characterized characterize VBN cord-319448-gt6uqfrl 162 32 by by IN cord-319448-gt6uqfrl 162 33 the the DT cord-319448-gt6uqfrl 162 34 Herxheimer Herxheimer NNP cord-319448-gt6uqfrl 162 35 reaction reaction NN cord-319448-gt6uqfrl 162 36 following follow VBG cord-319448-gt6uqfrl 162 37 treatment treatment NN cord-319448-gt6uqfrl 162 38 of of IN cord-319448-gt6uqfrl 162 39 syphilis syphili NNS cord-319448-gt6uqfrl 162 40 , , , cord-319448-gt6uqfrl 162 41 the the DT cord-319448-gt6uqfrl 162 42 similar similar JJ cord-319448-gt6uqfrl 162 43 reaction reaction NN cord-319448-gt6uqfrl 162 44 that that WDT cord-319448-gt6uqfrl 162 45 can can MD cord-319448-gt6uqfrl 162 46 occur occur VB cord-319448-gt6uqfrl 162 47 after after IN cord-319448-gt6uqfrl 162 48 the the DT cord-319448-gt6uqfrl 162 49 initiation initiation NN cord-319448-gt6uqfrl 162 50 of of IN cord-319448-gt6uqfrl 162 51 therapy therapy NN cord-319448-gt6uqfrl 162 52 for for IN cord-319448-gt6uqfrl 162 53 Pneumocystis Pneumocystis NNP cord-319448-gt6uqfrl 162 54 carinii carinii FW cord-319448-gt6uqfrl 162 55 pneumonia pneumonia NN cord-319448-gt6uqfrl 162 56 , , , cord-319448-gt6uqfrl 162 57 and and CC cord-319448-gt6uqfrl 162 58 serum serum NN cord-319448-gt6uqfrl 162 59 sickness sickness NN cord-319448-gt6uqfrl 162 60 following follow VBG cord-319448-gt6uqfrl 162 61 the the DT cord-319448-gt6uqfrl 162 62 injection injection NN cord-319448-gt6uqfrl 162 63 of of IN cord-319448-gt6uqfrl 162 64 foreign foreign JJ cord-319448-gt6uqfrl 162 65 protein protein NN cord-319448-gt6uqfrl 162 66 . . . cord-319448-gt6uqfrl 163 1 this this DT cord-319448-gt6uqfrl 164 1 we -PRON- PRP cord-319448-gt6uqfrl 164 2 make make VBP cord-319448-gt6uqfrl 164 3 no no DT cord-319448-gt6uqfrl 164 4 apologies apology NNS cord-319448-gt6uqfrl 164 5 , , , cord-319448-gt6uqfrl 164 6 as as IN cord-319448-gt6uqfrl 164 7 the the DT cord-319448-gt6uqfrl 164 8 field field NN cord-319448-gt6uqfrl 164 9 of of IN cord-319448-gt6uqfrl 164 10 microbial microbial JJ cord-319448-gt6uqfrl 164 11 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 164 12 seeks seek VBZ cord-319448-gt6uqfrl 164 13 to to TO cord-319448-gt6uqfrl 164 14 understand understand VB cord-319448-gt6uqfrl 164 15 how how WRB cord-319448-gt6uqfrl 164 16 microorganisms microorganism NNS cord-319448-gt6uqfrl 164 17 cause cause VBP cord-319448-gt6uqfrl 164 18 disease disease NN cord-319448-gt6uqfrl 164 19 , , , cord-319448-gt6uqfrl 164 20 an an DT cord-319448-gt6uqfrl 164 21 outcome outcome NN cord-319448-gt6uqfrl 164 22 that that WDT cord-319448-gt6uqfrl 164 23 can can MD cord-319448-gt6uqfrl 164 24 only only RB cord-319448-gt6uqfrl 164 25 occur occur VB cord-319448-gt6uqfrl 164 26 in in IN cord-319448-gt6uqfrl 164 27 a a DT cord-319448-gt6uqfrl 164 28 susceptible susceptible JJ cord-319448-gt6uqfrl 164 29 host host NN cord-319448-gt6uqfrl 164 30 . . . cord-319448-gt6uqfrl 165 1 The the DT cord-319448-gt6uqfrl 165 2 only only JJ cord-319448-gt6uqfrl 165 3 components component NNS cord-319448-gt6uqfrl 165 4 of of IN cord-319448-gt6uqfrl 165 5 the the DT cord-319448-gt6uqfrl 165 6 damage damage NN cord-319448-gt6uqfrl 165 7 - - HYPH cord-319448-gt6uqfrl 165 8 response response NN cord-319448-gt6uqfrl 165 9 framework framework NN cord-319448-gt6uqfrl 165 10 are be VBP cord-319448-gt6uqfrl 165 11 microorganisms microorganism NNS cord-319448-gt6uqfrl 165 12 that that WDT cord-319448-gt6uqfrl 165 13 can can MD cord-319448-gt6uqfrl 165 14 cause cause VB cord-319448-gt6uqfrl 165 15 disease disease NN cord-319448-gt6uqfrl 165 16 and and CC cord-319448-gt6uqfrl 165 17 hosts host NNS cord-319448-gt6uqfrl 165 18 . . . cord-319448-gt6uqfrl 166 1 Similarly similarly RB cord-319448-gt6uqfrl 166 2 , , , cord-319448-gt6uqfrl 166 3 the the DT cord-319448-gt6uqfrl 166 4 outcomes outcome NNS cord-319448-gt6uqfrl 166 5 of of IN cord-319448-gt6uqfrl 166 6 a a DT cord-319448-gt6uqfrl 166 7 host host NN cord-319448-gt6uqfrl 166 8 - - HYPH cord-319448-gt6uqfrl 166 9 microorganism microorganism NN cord-319448-gt6uqfrl 166 10 interaction interaction NN cord-319448-gt6uqfrl 166 11 after after IN cord-319448-gt6uqfrl 166 12 initial initial JJ cord-319448-gt6uqfrl 166 13 contact contact NN cord-319448-gt6uqfrl 166 14 are be VBP cord-319448-gt6uqfrl 166 15 simplified simplify VBN cord-319448-gt6uqfrl 166 16 to to IN cord-319448-gt6uqfrl 166 17 infection infection NN cord-319448-gt6uqfrl 166 18 , , , cord-319448-gt6uqfrl 166 19 commensalism commensalism NN cord-319448-gt6uqfrl 166 20 , , , cord-319448-gt6uqfrl 166 21 colonization colonization NN cord-319448-gt6uqfrl 166 22 , , , cord-319448-gt6uqfrl 166 23 persistence persistence NN cord-319448-gt6uqfrl 166 24 ( ( -LRB- cord-319448-gt6uqfrl 166 25 latency latency NNP cord-319448-gt6uqfrl 166 26 ) ) -RRB- cord-319448-gt6uqfrl 166 27 and and CC cord-319448-gt6uqfrl 166 28 disease disease NN cord-319448-gt6uqfrl 166 29 . . . cord-319448-gt6uqfrl 167 1 The the DT cord-319448-gt6uqfrl 167 2 use use NN cord-319448-gt6uqfrl 167 3 of of IN cord-319448-gt6uqfrl 167 4 damage damage NN cord-319448-gt6uqfrl 167 5 as as IN cord-319448-gt6uqfrl 167 6 the the DT cord-319448-gt6uqfrl 167 7 common common JJ cord-319448-gt6uqfrl 167 8 classification classification NN cord-319448-gt6uqfrl 167 9 for for IN cord-319448-gt6uqfrl 167 10 microbial microbial JJ cord-319448-gt6uqfrl 167 11 pathogenicity pathogenicity NN cord-319448-gt6uqfrl 167 12 and and CC cord-319448-gt6uqfrl 167 13 virulence virulence NN cord-319448-gt6uqfrl 167 14 simplifies simplify VBZ cord-319448-gt6uqfrl 167 15 the the DT cord-319448-gt6uqfrl 167 16 lexicon lexicon NN cord-319448-gt6uqfrl 167 17 of of IN cord-319448-gt6uqfrl 167 18 microbial microbial JJ cord-319448-gt6uqfrl 167 19 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 167 20 and and CC cord-319448-gt6uqfrl 167 21 makes make VBZ cord-319448-gt6uqfrl 167 22 it -PRON- PRP cord-319448-gt6uqfrl 167 23 possible possible JJ cord-319448-gt6uqfrl 167 24 to to TO cord-319448-gt6uqfrl 167 25 discard discard VB cord-319448-gt6uqfrl 167 26 ambiguous ambiguous JJ cord-319448-gt6uqfrl 167 27 terms term NNS cord-319448-gt6uqfrl 167 28 , , , cord-319448-gt6uqfrl 167 29 such such JJ cord-319448-gt6uqfrl 167 30 as as IN cord-319448-gt6uqfrl 167 31 commensal commensal JJ cord-319448-gt6uqfrl 167 32 , , , cord-319448-gt6uqfrl 167 33 saprophyte saprophyte NNP cord-319448-gt6uqfrl 167 34 , , , cord-319448-gt6uqfrl 167 35 opportunist opportunist NN cord-319448-gt6uqfrl 167 36 , , , cord-319448-gt6uqfrl 167 37 exposure exposure NN cord-319448-gt6uqfrl 167 38 and and CC cord-319448-gt6uqfrl 167 39 carriage carriage NN cord-319448-gt6uqfrl 167 40 1,2,4,5 1,2,4,5 CD cord-319448-gt6uqfrl 167 41 . . . cord-319448-gt6uqfrl 168 1 The the DT cord-319448-gt6uqfrl 168 2 damage damage NN cord-319448-gt6uqfrl 168 3 - - HYPH cord-319448-gt6uqfrl 168 4 response response NN cord-319448-gt6uqfrl 168 5 framework framework NN cord-319448-gt6uqfrl 168 6 was be VBD cord-319448-gt6uqfrl 168 7 proposed propose VBN cord-319448-gt6uqfrl 168 8 based base VBN cord-319448-gt6uqfrl 168 9 on on IN cord-319448-gt6uqfrl 168 10 clinical clinical JJ cord-319448-gt6uqfrl 168 11 and and CC cord-319448-gt6uqfrl 168 12 experimental experimental JJ cord-319448-gt6uqfrl 168 13 observations observation NNS cord-319448-gt6uqfrl 168 14 of of IN cord-319448-gt6uqfrl 168 15 the the DT cord-319448-gt6uqfrl 168 16 outcome outcome NN cord-319448-gt6uqfrl 168 17 of of IN cord-319448-gt6uqfrl 168 18 host host NN cord-319448-gt6uqfrl 168 19 - - HYPH cord-319448-gt6uqfrl 168 20 microorganism microorganism NN cord-319448-gt6uqfrl 168 21 interactions interaction NNS cord-319448-gt6uqfrl 168 22 . . . cord-319448-gt6uqfrl 169 1 Despite despite IN cord-319448-gt6uqfrl 169 2 being be VBG cord-319448-gt6uqfrl 169 3 supported support VBN cord-319448-gt6uqfrl 169 4 by by IN cord-319448-gt6uqfrl 169 5 a a DT cord-319448-gt6uqfrl 169 6 large large JJ cord-319448-gt6uqfrl 169 7 body body NN cord-319448-gt6uqfrl 169 8 of of IN cord-319448-gt6uqfrl 169 9 observational observational JJ cord-319448-gt6uqfrl 169 10 evidence evidence NN cord-319448-gt6uqfrl 169 11 , , , cord-319448-gt6uqfrl 169 12 it -PRON- PRP cord-319448-gt6uqfrl 169 13 should should MD cord-319448-gt6uqfrl 169 14 also also RB cord-319448-gt6uqfrl 169 15 be be VB cord-319448-gt6uqfrl 169 16 subjected subject VBN cord-319448-gt6uqfrl 169 17 to to IN cord-319448-gt6uqfrl 169 18 experimental experimental JJ cord-319448-gt6uqfrl 169 19 validation validation NN cord-319448-gt6uqfrl 169 20 and/or and/or CC cord-319448-gt6uqfrl 169 21 refutation refutation NN cord-319448-gt6uqfrl 169 22 . . . cord-319448-gt6uqfrl 170 1 To to TO cord-319448-gt6uqfrl 170 2 accomplish accomplish VB cord-319448-gt6uqfrl 170 3 this this DT cord-319448-gt6uqfrl 170 4 , , , cord-319448-gt6uqfrl 170 5 it -PRON- PRP cord-319448-gt6uqfrl 170 6 will will MD cord-319448-gt6uqfrl 170 7 be be VB cord-319448-gt6uqfrl 170 8 necessary necessary JJ cord-319448-gt6uqfrl 170 9 to to TO cord-319448-gt6uqfrl 170 10 develop develop VB cord-319448-gt6uqfrl 170 11 better well JJR cord-319448-gt6uqfrl 170 12 quantitative quantitative JJ cord-319448-gt6uqfrl 170 13 and and CC cord-319448-gt6uqfrl 170 14 qualitative qualitative JJ cord-319448-gt6uqfrl 170 15 measures measure NNS cord-319448-gt6uqfrl 170 16 of of IN cord-319448-gt6uqfrl 170 17 the the DT cord-319448-gt6uqfrl 170 18 immune immune JJ cord-319448-gt6uqfrl 170 19 response response NN cord-319448-gt6uqfrl 170 20 and and CC cord-319448-gt6uqfrl 170 21 host host NN cord-319448-gt6uqfrl 170 22 damage damage NN cord-319448-gt6uqfrl 170 23 , , , cord-319448-gt6uqfrl 170 24 as as IN cord-319448-gt6uqfrl 170 25 , , , cord-319448-gt6uqfrl 170 26 at at IN cord-319448-gt6uqfrl 170 27 present present NN cord-319448-gt6uqfrl 170 28 , , , cord-319448-gt6uqfrl 170 29 the the DT cord-319448-gt6uqfrl 170 30 information information NN cord-319448-gt6uqfrl 170 31 needed need VBD cord-319448-gt6uqfrl 170 32 to to TO cord-319448-gt6uqfrl 170 33 validate validate VB cord-319448-gt6uqfrl 170 34 or or CC cord-319448-gt6uqfrl 170 35 refute refute VB cord-319448-gt6uqfrl 170 36 the the DT cord-319448-gt6uqfrl 170 37 damage damage NN cord-319448-gt6uqfrl 170 38 - - HYPH cord-319448-gt6uqfrl 170 39 response response NN cord-319448-gt6uqfrl 170 40 framework framework NN cord-319448-gt6uqfrl 170 41 is be VBZ cord-319448-gt6uqfrl 170 42 unavailable unavailable JJ cord-319448-gt6uqfrl 170 43 . . . cord-319448-gt6uqfrl 171 1 The the DT cord-319448-gt6uqfrl 171 2 damage damage NN cord-319448-gt6uqfrl 171 3 - - HYPH cord-319448-gt6uqfrl 171 4 response response NN cord-319448-gt6uqfrl 171 5 framework framework NN cord-319448-gt6uqfrl 171 6 plots plot NNS cord-319448-gt6uqfrl 171 7 damage damage NN cord-319448-gt6uqfrl 171 8 as as IN cord-319448-gt6uqfrl 171 9 a a DT cord-319448-gt6uqfrl 171 10 function function NN cord-319448-gt6uqfrl 171 11 of of IN cord-319448-gt6uqfrl 171 12 the the DT cord-319448-gt6uqfrl 171 13 immune immune JJ cord-319448-gt6uqfrl 171 14 response response NN cord-319448-gt6uqfrl 171 15 and and CC cord-319448-gt6uqfrl 171 16 uses use VBZ cord-319448-gt6uqfrl 171 17 the the DT cord-319448-gt6uqfrl 171 18 qualifiers qualifier NNS cord-319448-gt6uqfrl 171 19 ' ' POS cord-319448-gt6uqfrl 171 20 strong strong JJ cord-319448-gt6uqfrl 171 21 ' ' '' cord-319448-gt6uqfrl 171 22 and and CC cord-319448-gt6uqfrl 171 23 ' ' `` cord-319448-gt6uqfrl 171 24 weak weak JJ cord-319448-gt6uqfrl 171 25 ' ' '' cord-319448-gt6uqfrl 171 26 to to TO cord-319448-gt6uqfrl 171 27 denote denote VB cord-319448-gt6uqfrl 171 28 quantitative quantitative JJ cord-319448-gt6uqfrl 171 29 and and CC cord-319448-gt6uqfrl 171 30 qualitative qualitative JJ cord-319448-gt6uqfrl 171 31 characteristics characteristic NNS cord-319448-gt6uqfrl 171 32 of of IN cord-319448-gt6uqfrl 171 33 the the DT cord-319448-gt6uqfrl 171 34 immune immune JJ cord-319448-gt6uqfrl 171 35 response response NN cord-319448-gt6uqfrl 171 36 . . . cord-319448-gt6uqfrl 172 1 We -PRON- PRP cord-319448-gt6uqfrl 172 2 appreciate appreciate VBP cord-319448-gt6uqfrl 172 3 that that IN cord-319448-gt6uqfrl 172 4 these these DT cord-319448-gt6uqfrl 172 5 terms term NNS cord-319448-gt6uqfrl 172 6 are be VBP cord-319448-gt6uqfrl 172 7 vague vague JJ cord-319448-gt6uqfrl 172 8 and and CC cord-319448-gt6uqfrl 172 9 , , , cord-319448-gt6uqfrl 172 10 as as IN cord-319448-gt6uqfrl 172 11 such such JJ cord-319448-gt6uqfrl 172 12 , , , cord-319448-gt6uqfrl 172 13 that that IN cord-319448-gt6uqfrl 172 14 they -PRON- PRP cord-319448-gt6uqfrl 172 15 might may MD cord-319448-gt6uqfrl 172 16 seem seem VB cord-319448-gt6uqfrl 172 17 to to TO cord-319448-gt6uqfrl 172 18 oversimplify oversimplify VB cord-319448-gt6uqfrl 172 19 the the DT cord-319448-gt6uqfrl 172 20 complex complex JJ cord-319448-gt6uqfrl 172 21 , , , cord-319448-gt6uqfrl 172 22 diverse diverse JJ cord-319448-gt6uqfrl 172 23 and and CC cord-319448-gt6uqfrl 172 24 multidimensional multidimensional JJ cord-319448-gt6uqfrl 172 25 nature nature NN cord-319448-gt6uqfrl 172 26 of of IN cord-319448-gt6uqfrl 172 27 the the DT cord-319448-gt6uqfrl 172 28 host host NN cord-319448-gt6uqfrl 172 29 response response NN cord-319448-gt6uqfrl 172 30 -which -which NN cord-319448-gt6uqfrl 172 31 includes include VBZ cord-319448-gt6uqfrl 172 32 both both DT cord-319448-gt6uqfrl 172 33 humoral humoral JJ cord-319448-gt6uqfrl 172 34 and and CC cord-319448-gt6uqfrl 172 35 cellular cellular JJ cord-319448-gt6uqfrl 172 36 components component NNS cord-319448-gt6uqfrl 172 37 of of IN cord-319448-gt6uqfrl 172 38 the the DT cord-319448-gt6uqfrl 172 39 innate innate JJ cord-319448-gt6uqfrl 172 40 and and CC cord-319448-gt6uqfrl 172 41 adaptive adaptive JJ cord-319448-gt6uqfrl 172 42 immune immune JJ cord-319448-gt6uqfrl 172 43 systems system NNS cord-319448-gt6uqfrl 172 44 . . . cord-319448-gt6uqfrl 173 1 pathogenicity pathogenicity NN cord-319448-gt6uqfrl 173 2 of of IN cord-319448-gt6uqfrl 173 3 a a DT cord-319448-gt6uqfrl 173 4 microorganism microorganism NN cord-319448-gt6uqfrl 173 5 . . . cord-319448-gt6uqfrl 174 1 Even even RB cord-319448-gt6uqfrl 174 2 highly highly RB cord-319448-gt6uqfrl 174 3 virulent virulent JJ cord-319448-gt6uqfrl 174 4 toxigenic toxigenic JJ cord-319448-gt6uqfrl 174 5 microorganisms microorganism NNS cord-319448-gt6uqfrl 174 6 are be VBP cord-319448-gt6uqfrl 174 7 not not RB cord-319448-gt6uqfrl 174 8 virulent virulent JJ cord-319448-gt6uqfrl 174 9 in in IN cord-319448-gt6uqfrl 174 10 hosts host NNS cord-319448-gt6uqfrl 174 11 that that WDT cord-319448-gt6uqfrl 174 12 have have VBP cord-319448-gt6uqfrl 174 13 been be VBN cord-319448-gt6uqfrl 174 14 immunized immunize VBN cord-319448-gt6uqfrl 174 15 with with IN cord-319448-gt6uqfrl 174 16 toxoid toxoid JJ cord-319448-gt6uqfrl 174 17 vaccines vaccine NNS cord-319448-gt6uqfrl 174 18 , , , cord-319448-gt6uqfrl 174 19 such such JJ cord-319448-gt6uqfrl 174 20 as as IN cord-319448-gt6uqfrl 174 21 tetanus tetanus NN cord-319448-gt6uqfrl 174 22 toxoid toxoid NN cord-319448-gt6uqfrl 174 23 . . . cord-319448-gt6uqfrl 175 1 Therefore therefore RB cord-319448-gt6uqfrl 175 2 , , , cord-319448-gt6uqfrl 175 3 although although IN cord-319448-gt6uqfrl 175 4 the the DT cord-319448-gt6uqfrl 175 5 existence existence NN cord-319448-gt6uqfrl 175 6 of of IN cord-319448-gt6uqfrl 175 7 microbial microbial JJ cord-319448-gt6uqfrl 175 8 virulence virulence NN cord-319448-gt6uqfrl 175 9 factors factor NNS cord-319448-gt6uqfrl 175 10 is be VBZ cord-319448-gt6uqfrl 175 11 incontrovertible incontrovertible JJ cord-319448-gt6uqfrl 175 12 , , , cord-319448-gt6uqfrl 175 13 for for IN cord-319448-gt6uqfrl 175 14 many many JJ cord-319448-gt6uqfrl 175 15 microorganisms microorganism NNS cord-319448-gt6uqfrl 175 16 it -PRON- PRP cord-319448-gt6uqfrl 175 17 is be VBZ cord-319448-gt6uqfrl 175 18 the the DT cord-319448-gt6uqfrl 175 19 ability ability NN cord-319448-gt6uqfrl 175 20 of of IN cord-319448-gt6uqfrl 175 21 these these DT cord-319448-gt6uqfrl 175 22 factors factor NNS cord-319448-gt6uqfrl 175 23 to to TO cord-319448-gt6uqfrl 175 24 override override VB cord-319448-gt6uqfrl 175 25 the the DT cord-319448-gt6uqfrl 175 26 mechanisms mechanism NNS cord-319448-gt6uqfrl 175 27 of of IN cord-319448-gt6uqfrl 175 28 host host NN cord-319448-gt6uqfrl 175 29 defence defence NN cord-319448-gt6uqfrl 175 30 that that WDT cord-319448-gt6uqfrl 175 31 makes make VBZ cord-319448-gt6uqfrl 175 32 them -PRON- PRP cord-319448-gt6uqfrl 175 33 VIRULENCE virulence NN cord-319448-gt6uqfrl 175 34 FACTORS factors NN cord-319448-gt6uqfrl 175 35 . . . cord-319448-gt6uqfrl 176 1 The the DT cord-319448-gt6uqfrl 176 2 damage damage NN cord-319448-gt6uqfrl 176 3 - - HYPH cord-319448-gt6uqfrl 176 4 response response NN cord-319448-gt6uqfrl 176 5 framework framework NN cord-319448-gt6uqfrl 176 6 is be VBZ cord-319448-gt6uqfrl 176 7 neither neither DT cord-319448-gt6uqfrl 176 8 microorganism microorganism NN cord-319448-gt6uqfrl 176 9 - - HYPH cord-319448-gt6uqfrl 176 10 centred centre VBN cord-319448-gt6uqfrl 176 11 nor nor CC cord-319448-gt6uqfrl 176 12 host host NN cord-319448-gt6uqfrl 176 13 - - HYPH cord-319448-gt6uqfrl 176 14 centred centre VBN cord-319448-gt6uqfrl 176 15 . . . cord-319448-gt6uqfrl 177 1 It -PRON- PRP cord-319448-gt6uqfrl 177 2 does do VBZ cord-319448-gt6uqfrl 177 3 , , , cord-319448-gt6uqfrl 177 4 however however RB cord-319448-gt6uqfrl 177 5 , , , cord-319448-gt6uqfrl 177 6 state state NN cord-319448-gt6uqfrl 177 7 that that IN cord-319448-gt6uqfrl 177 8 the the DT cord-319448-gt6uqfrl 177 9 outcome outcome NN cord-319448-gt6uqfrl 177 10 of of IN cord-319448-gt6uqfrl 177 11 host host NN cord-319448-gt6uqfrl 177 12 - - HYPH cord-319448-gt6uqfrl 177 13 microorganism microorganism NN cord-319448-gt6uqfrl 177 14 interactions interaction NNS cord-319448-gt6uqfrl 177 15 in in IN cord-319448-gt6uqfrl 177 16 a a DT cord-319448-gt6uqfrl 177 17 host host NN cord-319448-gt6uqfrl 177 18 is be VBZ cord-319448-gt6uqfrl 177 19 the the DT cord-319448-gt6uqfrl 177 20 defining define VBG cord-319448-gt6uqfrl 177 21 aspect aspect NN cord-319448-gt6uqfrl 177 22 of of IN cord-319448-gt6uqfrl 177 23 microbial microbial JJ cord-319448-gt6uqfrl 177 24 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 177 25 . . . cord-319448-gt6uqfrl 178 1 In in IN cord-319448-gt6uqfrl 178 2 this this DT cord-319448-gt6uqfrl 178 3 regard regard NN cord-319448-gt6uqfrl 178 4 , , , cord-319448-gt6uqfrl 178 5 the the DT cord-319448-gt6uqfrl 178 6 damage damage NN cord-319448-gt6uqfrl 178 7 - - HYPH cord-319448-gt6uqfrl 178 8 response response NN cord-319448-gt6uqfrl 178 9 framework framework NN cord-319448-gt6uqfrl 178 10 might may MD cord-319448-gt6uqfrl 178 11 be be VB cord-319448-gt6uqfrl 178 12 considered consider VBN cord-319448-gt6uqfrl 178 13 to to TO cord-319448-gt6uqfrl 178 14 be be VB cord-319448-gt6uqfrl 178 15 biased bias VBN cord-319448-gt6uqfrl 178 16 towards towards IN cord-319448-gt6uqfrl 178 17 the the DT cord-319448-gt6uqfrl 178 18 host host NN cord-319448-gt6uqfrl 178 19 . . . cord-319448-gt6uqfrl 179 1 However however RB cord-319448-gt6uqfrl 179 2 , , , cord-319448-gt6uqfrl 179 3 rather rather RB cord-319448-gt6uqfrl 179 4 than than IN cord-319448-gt6uqfrl 179 5 holding hold VBG cord-319448-gt6uqfrl 179 6 the the DT cord-319448-gt6uqfrl 179 7 host host NN cord-319448-gt6uqfrl 179 8 responsible responsible JJ cord-319448-gt6uqfrl 179 9 for for IN cord-319448-gt6uqfrl 179 10 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 179 11 , , , cord-319448-gt6uqfrl 179 12 the the DT cord-319448-gt6uqfrl 179 13 damage damage NN cord-319448-gt6uqfrl 179 14 - - HYPH cord-319448-gt6uqfrl 179 15 response response NN cord-319448-gt6uqfrl 179 16 framework framework NN cord-319448-gt6uqfrl 179 17 places place VBZ cord-319448-gt6uqfrl 179 18 the the DT cord-319448-gt6uqfrl 179 19 context context NN cord-319448-gt6uqfrl 179 20 of of IN cord-319448-gt6uqfrl 179 21 microbial microbial JJ cord-319448-gt6uqfrl 179 22 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 179 23 within within IN cord-319448-gt6uqfrl 179 24 the the DT cord-319448-gt6uqfrl 179 25 host host NN cord-319448-gt6uqfrl 179 26 . . . cord-319448-gt6uqfrl 180 1 For for IN cord-319448-gt6uqfrl 180 2 COLONIZATION COLONIZATION NNP cord-319448-gt6uqfrl 180 3 A a DT cord-319448-gt6uqfrl 180 4 state state NN cord-319448-gt6uqfrl 180 5 of of IN cord-319448-gt6uqfrl 180 6 host host NN cord-319448-gt6uqfrl 180 7 - - HYPH cord-319448-gt6uqfrl 180 8 microorganism microorganism NN cord-319448-gt6uqfrl 180 9 interaction interaction NN cord-319448-gt6uqfrl 180 10 that that WDT cord-319448-gt6uqfrl 180 11 leads lead VBZ cord-319448-gt6uqfrl 180 12 to to IN cord-319448-gt6uqfrl 180 13 a a DT cord-319448-gt6uqfrl 180 14 variable variable JJ cord-319448-gt6uqfrl 180 15 amount amount NN cord-319448-gt6uqfrl 180 16 of of IN cord-319448-gt6uqfrl 180 17 host host NN cord-319448-gt6uqfrl 180 18 damage damage NN cord-319448-gt6uqfrl 180 19 , , , cord-319448-gt6uqfrl 180 20 from from IN cord-319448-gt6uqfrl 180 21 minimal minimal JJ cord-319448-gt6uqfrl 180 22 to to IN cord-319448-gt6uqfrl 180 23 great great JJ cord-319448-gt6uqfrl 180 24 , , , cord-319448-gt6uqfrl 180 25 thereby thereby RB cord-319448-gt6uqfrl 180 26 reflecting reflect VBG cord-319448-gt6uqfrl 180 27 host host NN cord-319448-gt6uqfrl 180 28 immune immune JJ cord-319448-gt6uqfrl 180 29 responses response NNS cord-319448-gt6uqfrl 180 30 that that WDT cord-319448-gt6uqfrl 180 31 have have VBP cord-319448-gt6uqfrl 180 32 the the DT cord-319448-gt6uqfrl 180 33 capacity capacity NN cord-319448-gt6uqfrl 180 34 to to TO cord-319448-gt6uqfrl 180 35 eliminate eliminate VB cord-319448-gt6uqfrl 180 36 the the DT cord-319448-gt6uqfrl 180 37 microorganism microorganism NN cord-319448-gt6uqfrl 180 38 or or CC cord-319448-gt6uqfrl 180 39 to to TO cord-319448-gt6uqfrl 180 40 promote promote VB cord-319448-gt6uqfrl 180 41 the the DT cord-319448-gt6uqfrl 180 42 development development NN cord-319448-gt6uqfrl 180 43 of of IN cord-319448-gt6uqfrl 180 44 another another DT cord-319448-gt6uqfrl 180 45 state state NN cord-319448-gt6uqfrl 180 46 . . . cord-319448-gt6uqfrl 181 1 LATENCY LATENCY NNP cord-319448-gt6uqfrl 182 1 A a DT cord-319448-gt6uqfrl 182 2 state state NN cord-319448-gt6uqfrl 182 3 of of IN cord-319448-gt6uqfrl 182 4 host host NN cord-319448-gt6uqfrl 182 5 - - HYPH cord-319448-gt6uqfrl 182 6 microorganism microorganism NN cord-319448-gt6uqfrl 182 7 interaction interaction NN cord-319448-gt6uqfrl 182 8 in in IN cord-319448-gt6uqfrl 182 9 which which WDT cord-319448-gt6uqfrl 182 10 a a DT cord-319448-gt6uqfrl 182 11 microorganism microorganism NN cord-319448-gt6uqfrl 182 12 persists persist VBZ cord-319448-gt6uqfrl 182 13 in in IN cord-319448-gt6uqfrl 182 14 a a DT cord-319448-gt6uqfrl 182 15 host host NN cord-319448-gt6uqfrl 182 16 and and CC cord-319448-gt6uqfrl 182 17 can can MD cord-319448-gt6uqfrl 182 18 be be VB cord-319448-gt6uqfrl 182 19 associated associate VBN cord-319448-gt6uqfrl 182 20 with with IN cord-319448-gt6uqfrl 182 21 damage damage NN cord-319448-gt6uqfrl 182 22 that that WDT cord-319448-gt6uqfrl 182 23 can can MD cord-319448-gt6uqfrl 182 24 be be VB cord-319448-gt6uqfrl 182 25 evident evident JJ cord-319448-gt6uqfrl 182 26 at at IN cord-319448-gt6uqfrl 182 27 the the DT cord-319448-gt6uqfrl 182 28 cellular cellular JJ cord-319448-gt6uqfrl 182 29 or or CC cord-319448-gt6uqfrl 182 30 tissue tissue NN cord-319448-gt6uqfrl 182 31 level level NN cord-319448-gt6uqfrl 182 32 , , , cord-319448-gt6uqfrl 182 33 but but CC cord-319448-gt6uqfrl 182 34 is be VBZ cord-319448-gt6uqfrl 182 35 not not RB cord-319448-gt6uqfrl 182 36 associated associate VBN cord-319448-gt6uqfrl 182 37 with with IN cord-319448-gt6uqfrl 182 38 disease disease NN cord-319448-gt6uqfrl 182 39 . . . cord-319448-gt6uqfrl 183 1 A a DT cord-319448-gt6uqfrl 183 2 microbial microbial JJ cord-319448-gt6uqfrl 183 3 component component NN cord-319448-gt6uqfrl 183 4 that that WDT cord-319448-gt6uqfrl 183 5 can can MD cord-319448-gt6uqfrl 183 6 damage damage VB cord-319448-gt6uqfrl 183 7 a a DT cord-319448-gt6uqfrl 183 8 host host NN cord-319448-gt6uqfrl 183 9 . . . cord-319448-gt6uqfrl 184 1 The the DT cord-319448-gt6uqfrl 184 2 shortcomings shortcoming NNS cord-319448-gt6uqfrl 184 3 of of IN cord-319448-gt6uqfrl 184 4 the the DT cord-319448-gt6uqfrl 184 5 terms term NNS cord-319448-gt6uqfrl 184 6 ' ' POS cord-319448-gt6uqfrl 184 7 strong strong JJ cord-319448-gt6uqfrl 184 8 ' ' '' cord-319448-gt6uqfrl 184 9 and and CC cord-319448-gt6uqfrl 184 10 ' ' `` cord-319448-gt6uqfrl 184 11 weak weak JJ cord-319448-gt6uqfrl 184 12 ' ' '' cord-319448-gt6uqfrl 184 13 are be VBP cord-319448-gt6uqfrl 184 14 evident evident JJ cord-319448-gt6uqfrl 184 15 if if IN cord-319448-gt6uqfrl 184 16 the the DT cord-319448-gt6uqfrl 184 17 case case NN cord-319448-gt6uqfrl 184 18 of of IN cord-319448-gt6uqfrl 184 19 P. P. NNP cord-319448-gt6uqfrl 184 20 carinii carinii FW cord-319448-gt6uqfrl 184 21 pneumonia pneumonia NN cord-319448-gt6uqfrl 184 22 is be VBZ cord-319448-gt6uqfrl 184 23 considered consider VBN cord-319448-gt6uqfrl 184 24 . . . cord-319448-gt6uqfrl 185 1 This this DT cord-319448-gt6uqfrl 185 2 disease disease NN cord-319448-gt6uqfrl 185 3 occurs occur VBZ cord-319448-gt6uqfrl 185 4 almost almost RB cord-319448-gt6uqfrl 185 5 exclusively exclusively RB cord-319448-gt6uqfrl 185 6 in in IN cord-319448-gt6uqfrl 185 7 severely severely RB cord-319448-gt6uqfrl 185 8 immunocompromised immunocompromised JJ cord-319448-gt6uqfrl 185 9 individuals individual NNS cord-319448-gt6uqfrl 185 10 and and CC cord-319448-gt6uqfrl 185 11 , , , cord-319448-gt6uqfrl 185 12 consequently consequently RB cord-319448-gt6uqfrl 185 13 , , , cord-319448-gt6uqfrl 185 14 P. P. NNP cord-319448-gt6uqfrl 185 15 carinii carinii NNP cord-319448-gt6uqfrl 185 16 was be VBD cord-319448-gt6uqfrl 185 17 classified classify VBN cord-319448-gt6uqfrl 185 18 as as IN cord-319448-gt6uqfrl 185 19 a a DT cord-319448-gt6uqfrl 185 20 Class class NN cord-319448-gt6uqfrl 185 21 1 1 CD cord-319448-gt6uqfrl 185 22 pathogen pathogen NN cord-319448-gt6uqfrl 185 23 . . . cord-319448-gt6uqfrl 186 1 However however RB cord-319448-gt6uqfrl 186 2 , , , cord-319448-gt6uqfrl 186 3 clinical clinical JJ cord-319448-gt6uqfrl 186 4 experience experience NN cord-319448-gt6uqfrl 186 5 has have VBZ cord-319448-gt6uqfrl 186 6 shown show VBN cord-319448-gt6uqfrl 186 7 improved improve VBN cord-319448-gt6uqfrl 186 8 outcomes outcome NNS cord-319448-gt6uqfrl 186 9 in in IN cord-319448-gt6uqfrl 186 10 patients patient NNS cord-319448-gt6uqfrl 186 11 that that WDT cord-319448-gt6uqfrl 186 12 are be VBP cord-319448-gt6uqfrl 186 13 treated treat VBN cord-319448-gt6uqfrl 186 14 with with IN cord-319448-gt6uqfrl 186 15 corticosteroids corticosteroid NNS cord-319448-gt6uqfrl 186 16 , , , cord-319448-gt6uqfrl 186 17 which which WDT cord-319448-gt6uqfrl 186 18 indicates indicate VBZ cord-319448-gt6uqfrl 186 19 that that IN cord-319448-gt6uqfrl 186 20 lung lung NN cord-319448-gt6uqfrl 186 21 damage damage NN cord-319448-gt6uqfrl 186 22 in in IN cord-319448-gt6uqfrl 186 23 AIDS AIDS NNP cord-319448-gt6uqfrl 186 24 patients patient NNS cord-319448-gt6uqfrl 186 25 with with IN cord-319448-gt6uqfrl 186 26 P. P. NNP cord-319448-gt6uqfrl 186 27 carinii carinii FW cord-319448-gt6uqfrl 186 28 pneumonia pneumonia NN cord-319448-gt6uqfrl 186 29 is be VBZ cord-319448-gt6uqfrl 186 30 mediated mediate VBN cord-319448-gt6uqfrl 186 31 largely largely RB cord-319448-gt6uqfrl 186 32 by by IN cord-319448-gt6uqfrl 186 33 the the DT cord-319448-gt6uqfrl 186 34 residual residual JJ cord-319448-gt6uqfrl 186 35 immune immune JJ cord-319448-gt6uqfrl 186 36 system system NN cord-319448-gt6uqfrl 186 37 . . . cord-319448-gt6uqfrl 187 1 Therefore therefore RB cord-319448-gt6uqfrl 187 2 , , , cord-319448-gt6uqfrl 187 3 P. P. NNP cord-319448-gt6uqfrl 187 4 carinii carinii FW cord-319448-gt6uqfrl 187 5 pneumonia pneumonia NN cord-319448-gt6uqfrl 187 6 occurs occur VBZ cord-319448-gt6uqfrl 187 7 in in IN cord-319448-gt6uqfrl 187 8 individuals individual NNS cord-319448-gt6uqfrl 187 9 with with IN cord-319448-gt6uqfrl 187 10 impaired impair VBN cord-319448-gt6uqfrl 187 11 ( ( -LRB- cord-319448-gt6uqfrl 187 12 ' ' `` cord-319448-gt6uqfrl 187 13 weak weak JJ cord-319448-gt6uqfrl 187 14 ' ' '' cord-319448-gt6uqfrl 187 15 ) ) -RRB- cord-319448-gt6uqfrl 188 1 immune immune JJ cord-319448-gt6uqfrl 188 2 responses response NNS cord-319448-gt6uqfrl 188 3 , , , cord-319448-gt6uqfrl 188 4 but but CC cord-319448-gt6uqfrl 188 5 damage damage NN cord-319448-gt6uqfrl 188 6 is be VBZ cord-319448-gt6uqfrl 188 7 likely likely JJ cord-319448-gt6uqfrl 188 8 to to TO cord-319448-gt6uqfrl 188 9 be be VB cord-319448-gt6uqfrl 188 10 immune immune JJ cord-319448-gt6uqfrl 188 11 - - HYPH cord-319448-gt6uqfrl 188 12 mediated mediate VBN cord-319448-gt6uqfrl 188 13 . . . cord-319448-gt6uqfrl 189 1 If if IN cord-319448-gt6uqfrl 189 2 treated treat VBN cord-319448-gt6uqfrl 189 3 as as IN cord-319448-gt6uqfrl 189 4 singular singular JJ cord-319448-gt6uqfrl 189 5 parameters parameter NNS cord-319448-gt6uqfrl 189 6 , , , cord-319448-gt6uqfrl 189 7 measurements measurement NNS cord-319448-gt6uqfrl 189 8 of of IN cord-319448-gt6uqfrl 189 9 the the DT cord-319448-gt6uqfrl 189 10 immune immune JJ cord-319448-gt6uqfrl 189 11 response response NN cord-319448-gt6uqfrl 189 12 that that WDT cord-319448-gt6uqfrl 189 13 are be VBP cord-319448-gt6uqfrl 189 14 available available JJ cord-319448-gt6uqfrl 189 15 at at IN cord-319448-gt6uqfrl 189 16 present present JJ cord-319448-gt6uqfrl 189 17 , , , cord-319448-gt6uqfrl 189 18 such such JJ cord-319448-gt6uqfrl 189 19 as as IN cord-319448-gt6uqfrl 189 20 the the DT cord-319448-gt6uqfrl 189 21 amount amount NN cord-319448-gt6uqfrl 189 22 and and CC cord-319448-gt6uqfrl 189 23 type type NN cord-319448-gt6uqfrl 189 24 of of IN cord-319448-gt6uqfrl 189 25 antibody antibody NN cord-319448-gt6uqfrl 189 26 response response NN cord-319448-gt6uqfrl 189 27 , , , cord-319448-gt6uqfrl 189 28 delayed delay VBN cord-319448-gt6uqfrl 189 29 - - HYPH cord-319448-gt6uqfrl 189 30 type type NN cord-319448-gt6uqfrl 189 31 hypersensitivity hypersensitivity NN cord-319448-gt6uqfrl 189 32 , , , cord-319448-gt6uqfrl 189 33 lymphocyte lymphocyte NN cord-319448-gt6uqfrl 189 34 proliferation proliferation NN cord-319448-gt6uqfrl 189 35 , , , cord-319448-gt6uqfrl 189 36 cytokine cytokine NN cord-319448-gt6uqfrl 189 37 levels level NNS cord-319448-gt6uqfrl 189 38 or or CC cord-319448-gt6uqfrl 189 39 immunoglobulin immunoglobulin NN cord-319448-gt6uqfrl 189 40 E e NN cord-319448-gt6uqfrl 189 41 levels level NNS cord-319448-gt6uqfrl 189 42 , , , cord-319448-gt6uqfrl 189 43 are be VBP cord-319448-gt6uqfrl 189 44 too too RB cord-319448-gt6uqfrl 189 45 limited limited JJ cord-319448-gt6uqfrl 189 46 and and CC cord-319448-gt6uqfrl 189 47 one one CD cord-319448-gt6uqfrl 189 48 - - HYPH cord-319448-gt6uqfrl 189 49 dimensional dimensional JJ cord-319448-gt6uqfrl 189 50 to to TO cord-319448-gt6uqfrl 189 51 be be VB cord-319448-gt6uqfrl 189 52 useful useful JJ cord-319448-gt6uqfrl 189 53 quantitatively quantitatively RB cord-319448-gt6uqfrl 189 54 on on IN cord-319448-gt6uqfrl 189 55 the the DT cord-319448-gt6uqfrl 189 56 x x NN cord-319448-gt6uqfrl 189 57 - - HYPH cord-319448-gt6uqfrl 189 58 axis axis NN cord-319448-gt6uqfrl 189 59 of of IN cord-319448-gt6uqfrl 189 60 the the DT cord-319448-gt6uqfrl 189 61 damage damage NN cord-319448-gt6uqfrl 189 62 - - HYPH cord-319448-gt6uqfrl 189 63 response response NN cord-319448-gt6uqfrl 189 64 curves curve NNS cord-319448-gt6uqfrl 189 65 . . . cord-319448-gt6uqfrl 190 1 Even even RB cord-319448-gt6uqfrl 190 2 in in IN cord-319448-gt6uqfrl 190 3 combination combination NN cord-319448-gt6uqfrl 190 4 , , , cord-319448-gt6uqfrl 190 5 these these DT cord-319448-gt6uqfrl 190 6 parameters parameter NNS cord-319448-gt6uqfrl 190 7 are be VBP cord-319448-gt6uqfrl 190 8 not not RB cord-319448-gt6uqfrl 190 9 , , , cord-319448-gt6uqfrl 190 10 at at IN cord-319448-gt6uqfrl 190 11 present present JJ cord-319448-gt6uqfrl 190 12 , , , cord-319448-gt6uqfrl 190 13 useful useful JJ cord-319448-gt6uqfrl 190 14 as as IN cord-319448-gt6uqfrl 190 15 we -PRON- PRP cord-319448-gt6uqfrl 190 16 lack lack VBP cord-319448-gt6uqfrl 190 17 the the DT cord-319448-gt6uqfrl 190 18 knowledge knowledge NN cord-319448-gt6uqfrl 190 19 to to TO cord-319448-gt6uqfrl 190 20 devise devise VB cord-319448-gt6uqfrl 190 21 formulas formula NNS cord-319448-gt6uqfrl 190 22 that that WDT cord-319448-gt6uqfrl 190 23 could could MD cord-319448-gt6uqfrl 190 24 take take VB cord-319448-gt6uqfrl 190 25 their -PRON- PRP$ cord-319448-gt6uqfrl 190 26 relative relative JJ cord-319448-gt6uqfrl 190 27 contributions contribution NNS cord-319448-gt6uqfrl 190 28 into into IN cord-319448-gt6uqfrl 190 29 account account NN cord-319448-gt6uqfrl 190 30 . . . cord-319448-gt6uqfrl 191 1 Similarly similarly RB cord-319448-gt6uqfrl 191 2 , , , cord-319448-gt6uqfrl 191 3 measures measure NNS cord-319448-gt6uqfrl 191 4 of of IN cord-319448-gt6uqfrl 191 5 damage damage NN cord-319448-gt6uqfrl 191 6 , , , cord-319448-gt6uqfrl 191 7 such such JJ cord-319448-gt6uqfrl 191 8 as as IN cord-319448-gt6uqfrl 191 9 fever fever NN cord-319448-gt6uqfrl 191 10 , , , cord-319448-gt6uqfrl 191 11 organ organ NN cord-319448-gt6uqfrl 191 12 dysfunction dysfunction NN cord-319448-gt6uqfrl 191 13 and and CC cord-319448-gt6uqfrl 191 14 cytokine cytokine NN cord-319448-gt6uqfrl 191 15 levels level NNS cord-319448-gt6uqfrl 191 16 in in IN cord-319448-gt6uqfrl 191 17 serum serum NN cord-319448-gt6uqfrl 191 18 , , , cord-319448-gt6uqfrl 191 19 are be VBP cord-319448-gt6uqfrl 191 20 too too RB cord-319448-gt6uqfrl 191 21 insensitive insensitive JJ cord-319448-gt6uqfrl 191 22 to to TO cord-319448-gt6uqfrl 191 23 provide provide VB cord-319448-gt6uqfrl 191 24 an an DT cord-319448-gt6uqfrl 191 25 accurate accurate JJ cord-319448-gt6uqfrl 191 26 measure measure NN cord-319448-gt6uqfrl 191 27 of of IN cord-319448-gt6uqfrl 191 28 the the DT cord-319448-gt6uqfrl 191 29 amount amount NN cord-319448-gt6uqfrl 191 30 and and CC cord-319448-gt6uqfrl 191 31 quality quality NN cord-319448-gt6uqfrl 191 32 of of IN cord-319448-gt6uqfrl 191 33 damage damage NN cord-319448-gt6uqfrl 191 34 that that WDT cord-319448-gt6uqfrl 191 35 results result VBZ cord-319448-gt6uqfrl 191 36 from from IN cord-319448-gt6uqfrl 191 37 the the DT cord-319448-gt6uqfrl 191 38 host host NN cord-319448-gt6uqfrl 191 39 - - HYPH cord-319448-gt6uqfrl 191 40 microorganism microorganism NN cord-319448-gt6uqfrl 191 41 interaction interaction NN cord-319448-gt6uqfrl 191 42 . . . cord-319448-gt6uqfrl 192 1 Damage damage NN cord-319448-gt6uqfrl 192 2 , , , cord-319448-gt6uqfrl 192 3 like like IN cord-319448-gt6uqfrl 192 4 the the DT cord-319448-gt6uqfrl 192 5 immune immune JJ cord-319448-gt6uqfrl 192 6 response response NN cord-319448-gt6uqfrl 192 7 , , , cord-319448-gt6uqfrl 192 8 is be VBZ cord-319448-gt6uqfrl 192 9 the the DT cord-319448-gt6uqfrl 192 10 result result NN cord-319448-gt6uqfrl 192 11 of of IN cord-319448-gt6uqfrl 192 12 multiple multiple JJ cord-319448-gt6uqfrl 192 13 events event NNS cord-319448-gt6uqfrl 192 14 and and CC cord-319448-gt6uqfrl 192 15 their -PRON- PRP$ cord-319448-gt6uqfrl 192 16 contributions contribution NNS cord-319448-gt6uqfrl 192 17 from from IN cord-319448-gt6uqfrl 192 18 cellular cellular JJ cord-319448-gt6uqfrl 192 19 , , , cord-319448-gt6uqfrl 192 20 tissue tissue NN cord-319448-gt6uqfrl 192 21 and and CC cord-319448-gt6uqfrl 192 22 organ organ NN cord-319448-gt6uqfrl 192 23 toxicity toxicity NN cord-319448-gt6uqfrl 192 24 . . . cord-319448-gt6uqfrl 193 1 For for IN cord-319448-gt6uqfrl 193 2 example example NN cord-319448-gt6uqfrl 193 3 , , , cord-319448-gt6uqfrl 193 4 it -PRON- PRP cord-319448-gt6uqfrl 193 5 has have VBZ cord-319448-gt6uqfrl 193 6 been be VBN cord-319448-gt6uqfrl 193 7 shown show VBN cord-319448-gt6uqfrl 193 8 that that IN cord-319448-gt6uqfrl 193 9 the the DT cord-319448-gt6uqfrl 193 10 interaction interaction NN cord-319448-gt6uqfrl 193 11 of of IN cord-319448-gt6uqfrl 193 12 C. C. NNP cord-319448-gt6uqfrl 193 13 albicans albican NNS cord-319448-gt6uqfrl 193 14 with with IN cord-319448-gt6uqfrl 193 15 different different JJ cord-319448-gt6uqfrl 193 16 host host NN cord-319448-gt6uqfrl 193 17 effector effector NN cord-319448-gt6uqfrl 193 18 cell cell NN cord-319448-gt6uqfrl 193 19 receptors receptor NNS cord-319448-gt6uqfrl 193 20 can can MD cord-319448-gt6uqfrl 193 21 result result VB cord-319448-gt6uqfrl 193 22 in in IN cord-319448-gt6uqfrl 193 23 different different JJ cord-319448-gt6uqfrl 193 24 inflammatory inflammatory JJ cord-319448-gt6uqfrl 193 25 profiles profile NNS cord-319448-gt6uqfrl 193 26 , , , cord-319448-gt6uqfrl 193 27 which which WDT cord-319448-gt6uqfrl 193 28 , , , cord-319448-gt6uqfrl 193 29 in in IN cord-319448-gt6uqfrl 193 30 turn turn NN cord-319448-gt6uqfrl 193 31 , , , cord-319448-gt6uqfrl 193 32 translate translate VB cord-319448-gt6uqfrl 193 33 into into IN cord-319448-gt6uqfrl 193 34 differences difference NNS cord-319448-gt6uqfrl 193 35 in in IN cord-319448-gt6uqfrl 193 36 virulence virulence NN cord-319448-gt6uqfrl 193 37 25 25 CD cord-319448-gt6uqfrl 193 38 . . . cord-319448-gt6uqfrl 194 1 However however RB cord-319448-gt6uqfrl 194 2 , , , cord-319448-gt6uqfrl 194 3 at at IN cord-319448-gt6uqfrl 194 4 present present NN cord-319448-gt6uqfrl 194 5 , , , cord-319448-gt6uqfrl 194 6 we -PRON- PRP cord-319448-gt6uqfrl 194 7 can can MD cord-319448-gt6uqfrl 194 8 not not RB cord-319448-gt6uqfrl 194 9 predict predict VB cord-319448-gt6uqfrl 194 10 the the DT cord-319448-gt6uqfrl 194 11 point point NN cord-319448-gt6uqfrl 194 12 at at IN cord-319448-gt6uqfrl 194 13 which which WDT cord-319448-gt6uqfrl 194 14 subclinical subclinical JJ cord-319448-gt6uqfrl 194 15 damage damage NN cord-319448-gt6uqfrl 194 16 becomes become VBZ cord-319448-gt6uqfrl 194 17 clinical clinical JJ cord-319448-gt6uqfrl 194 18 disease disease NN cord-319448-gt6uqfrl 194 19 or or CC cord-319448-gt6uqfrl 194 20 , , , cord-319448-gt6uqfrl 194 21 indeed indeed RB cord-319448-gt6uqfrl 194 22 , , , cord-319448-gt6uqfrl 194 23 the the DT cord-319448-gt6uqfrl 194 24 level level NN cord-319448-gt6uqfrl 194 25 of of IN cord-319448-gt6uqfrl 194 26 disease disease NN cord-319448-gt6uqfrl 194 27 that that WDT cord-319448-gt6uqfrl 194 28 results result VBZ cord-319448-gt6uqfrl 194 29 in in IN cord-319448-gt6uqfrl 194 30 the the DT cord-319448-gt6uqfrl 194 31 death death NN cord-319448-gt6uqfrl 194 32 of of IN cord-319448-gt6uqfrl 194 33 the the DT cord-319448-gt6uqfrl 194 34 organism organism NN cord-319448-gt6uqfrl 194 35 . . . cord-319448-gt6uqfrl 195 1 Therefore therefore RB cord-319448-gt6uqfrl 195 2 , , , cord-319448-gt6uqfrl 195 3 the the DT cord-319448-gt6uqfrl 195 4 correct correct JJ cord-319448-gt6uqfrl 195 5 parameters parameter NNS cord-319448-gt6uqfrl 195 6 for for IN cord-319448-gt6uqfrl 195 7 plotting plot VBG cord-319448-gt6uqfrl 195 8 on on IN cord-319448-gt6uqfrl 195 9 the the DT cord-319448-gt6uqfrl 195 10 x x NN cord-319448-gt6uqfrl 195 11 - - : cord-319448-gt6uqfrl 195 12 and and CC cord-319448-gt6uqfrl 195 13 y y NNP cord-319448-gt6uqfrl 195 14 - - HYPH cord-319448-gt6uqfrl 195 15 axes axis NNS cord-319448-gt6uqfrl 195 16 should should MD cord-319448-gt6uqfrl 195 17 be be VB cord-319448-gt6uqfrl 195 18 functions function NNS cord-319448-gt6uqfrl 195 19 of of IN cord-319448-gt6uqfrl 195 20 multiple multiple JJ cord-319448-gt6uqfrl 195 21 variables variable NNS cord-319448-gt6uqfrl 195 22 that that WDT cord-319448-gt6uqfrl 195 23 include include VBP cord-319448-gt6uqfrl 195 24 the the DT cord-319448-gt6uqfrl 195 25 contribution contribution NN cord-319448-gt6uqfrl 195 26 of of IN cord-319448-gt6uqfrl 195 27 multiple multiple JJ cord-319448-gt6uqfrl 195 28 components component NNS cord-319448-gt6uqfrl 195 29 of of IN cord-319448-gt6uqfrl 195 30 the the DT cord-319448-gt6uqfrl 195 31 immune immune JJ cord-319448-gt6uqfrl 195 32 system system NN cord-319448-gt6uqfrl 195 33 and and CC cord-319448-gt6uqfrl 195 34 damage damage NN cord-319448-gt6uqfrl 195 35 , , , cord-319448-gt6uqfrl 195 36 respectively respectively RB cord-319448-gt6uqfrl 195 37 . . . cord-319448-gt6uqfrl 196 1 The the DT cord-319448-gt6uqfrl 196 2 damage damage NN cord-319448-gt6uqfrl 196 3 - - HYPH cord-319448-gt6uqfrl 196 4 response response NN cord-319448-gt6uqfrl 196 5 framework framework NN cord-319448-gt6uqfrl 196 6 proposes propose VBZ cord-319448-gt6uqfrl 196 7 classifications classification NNS cord-319448-gt6uqfrl 196 8 , , , cord-319448-gt6uqfrl 196 9 statements statement NNS cord-319448-gt6uqfrl 196 10 and and CC cord-319448-gt6uqfrl 196 11 predictions prediction NNS cord-319448-gt6uqfrl 196 12 that that WDT cord-319448-gt6uqfrl 196 13 are be VBP cord-319448-gt6uqfrl 196 14 , , , cord-319448-gt6uqfrl 196 15 in in IN cord-319448-gt6uqfrl 196 16 principle principle NN cord-319448-gt6uqfrl 196 17 , , , cord-319448-gt6uqfrl 196 18 amenable amenable JJ cord-319448-gt6uqfrl 196 19 to to IN cord-319448-gt6uqfrl 196 20 experimental experimental JJ cord-319448-gt6uqfrl 196 21 testing testing NN cord-319448-gt6uqfrl 196 22 . . . cord-319448-gt6uqfrl 197 1 We -PRON- PRP cord-319448-gt6uqfrl 197 2 anticipate anticipate VBP cord-319448-gt6uqfrl 197 3 that that IN cord-319448-gt6uqfrl 197 4 , , , cord-319448-gt6uqfrl 197 5 in in IN cord-319448-gt6uqfrl 197 6 the the DT cord-319448-gt6uqfrl 197 7 future future NN cord-319448-gt6uqfrl 197 8 , , , cord-319448-gt6uqfrl 197 9 accurate accurate JJ cord-319448-gt6uqfrl 197 10 measurements measurement NNS cord-319448-gt6uqfrl 197 11 of of IN cord-319448-gt6uqfrl 197 12 host host NN cord-319448-gt6uqfrl 197 13 damage damage NN cord-319448-gt6uqfrl 197 14 and and CC cord-319448-gt6uqfrl 197 15 the the DT cord-319448-gt6uqfrl 197 16 immune immune JJ cord-319448-gt6uqfrl 197 17 response response NN cord-319448-gt6uqfrl 197 18 will will MD cord-319448-gt6uqfrl 197 19 be be VB cord-319448-gt6uqfrl 197 20 available available JJ cord-319448-gt6uqfrl 197 21 , , , cord-319448-gt6uqfrl 197 22 which which WDT cord-319448-gt6uqfrl 197 23 will will MD cord-319448-gt6uqfrl 197 24 allow allow VB cord-319448-gt6uqfrl 197 25 the the DT cord-319448-gt6uqfrl 197 26 generation generation NN cord-319448-gt6uqfrl 197 27 of of IN cord-319448-gt6uqfrl 197 28 experimental experimental JJ cord-319448-gt6uqfrl 197 29 curves curve NNS cord-319448-gt6uqfrl 197 30 to to IN cord-319448-gt6uqfrl 197 31 which which WDT cord-319448-gt6uqfrl 197 32 mathematical mathematical JJ cord-319448-gt6uqfrl 197 33 functions function NNS cord-319448-gt6uqfrl 197 34 can can MD cord-319448-gt6uqfrl 197 35 then then RB cord-319448-gt6uqfrl 197 36 be be VB cord-319448-gt6uqfrl 197 37 fitted fit VBN cord-319448-gt6uqfrl 197 38 to to TO cord-319448-gt6uqfrl 197 39 formally formally RB cord-319448-gt6uqfrl 197 40 describe describe VB cord-319448-gt6uqfrl 197 41 the the DT cord-319448-gt6uqfrl 197 42 host host NN cord-319448-gt6uqfrl 197 43 - - HYPH cord-319448-gt6uqfrl 197 44 microorganism microorganism NN cord-319448-gt6uqfrl 197 45 interaction interaction NN cord-319448-gt6uqfrl 197 46 . . . cord-319448-gt6uqfrl 198 1 Any any DT cord-319448-gt6uqfrl 198 2 effort effort NN cord-319448-gt6uqfrl 198 3 to to TO cord-319448-gt6uqfrl 198 4 investigate investigate VB cord-319448-gt6uqfrl 198 5 the the DT cord-319448-gt6uqfrl 198 6 validity validity NN cord-319448-gt6uqfrl 198 7 of of IN cord-319448-gt6uqfrl 198 8 the the DT cord-319448-gt6uqfrl 198 9 damageresponse damageresponse NNP cord-319448-gt6uqfrl 198 10 framework framework NN cord-319448-gt6uqfrl 198 11 is be VBZ cord-319448-gt6uqfrl 198 12 likely likely JJ cord-319448-gt6uqfrl 198 13 to to TO cord-319448-gt6uqfrl 198 14 stimulate stimulate VB cord-319448-gt6uqfrl 198 15 research research NN cord-319448-gt6uqfrl 198 16 into into IN cord-319448-gt6uqfrl 198 17 the the DT cord-319448-gt6uqfrl 198 18 relationship relationship NN cord-319448-gt6uqfrl 198 19 between between IN cord-319448-gt6uqfrl 198 20 host host NN cord-319448-gt6uqfrl 198 21 damage damage NN cord-319448-gt6uqfrl 198 22 and and CC cord-319448-gt6uqfrl 198 23 the the DT cord-319448-gt6uqfrl 198 24 immune immune JJ cord-319448-gt6uqfrl 198 25 response response NN cord-319448-gt6uqfrl 198 26 . . . cord-319448-gt6uqfrl 199 1 Such such JJ cord-319448-gt6uqfrl 199 2 endeavours endeavour NNS cord-319448-gt6uqfrl 199 3 will will MD cord-319448-gt6uqfrl 199 4 provide provide VB cord-319448-gt6uqfrl 199 5 new new JJ cord-319448-gt6uqfrl 199 6 scientific scientific JJ cord-319448-gt6uqfrl 199 7 insights insight NNS cord-319448-gt6uqfrl 199 8 , , , cord-319448-gt6uqfrl 199 9 irrespective irrespective RB cord-319448-gt6uqfrl 199 10 of of IN cord-319448-gt6uqfrl 199 11 whether whether IN cord-319448-gt6uqfrl 199 12 the the DT cord-319448-gt6uqfrl 199 13 framework framework NN cord-319448-gt6uqfrl 199 14 is be VBZ cord-319448-gt6uqfrl 199 15 ultimately ultimately RB cord-319448-gt6uqfrl 199 16 validated validate VBN cord-319448-gt6uqfrl 199 17 or or CC cord-319448-gt6uqfrl 199 18 falsified falsify VBN cord-319448-gt6uqfrl 199 19 . . . cord-319448-gt6uqfrl 200 1 We -PRON- PRP cord-319448-gt6uqfrl 200 2 anticipate anticipate VBP cord-319448-gt6uqfrl 200 3 several several JJ cord-319448-gt6uqfrl 200 4 important important JJ cord-319448-gt6uqfrl 200 5 uses use NNS cord-319448-gt6uqfrl 200 6 of of IN cord-319448-gt6uqfrl 200 7 the the DT cord-319448-gt6uqfrl 200 8 damageresponse damageresponse NNP cord-319448-gt6uqfrl 200 9 framework framework NN cord-319448-gt6uqfrl 200 10 . . . cord-319448-gt6uqfrl 201 1 First first RB cord-319448-gt6uqfrl 201 2 , , , cord-319448-gt6uqfrl 201 3 as as IN cord-319448-gt6uqfrl 201 4 has have VBZ cord-319448-gt6uqfrl 201 5 already already RB cord-319448-gt6uqfrl 201 6 been be VBN cord-319448-gt6uqfrl 201 7 alluded allude VBN cord-319448-gt6uqfrl 201 8 to to IN cord-319448-gt6uqfrl 201 9 , , , cord-319448-gt6uqfrl 201 10 efforts effort NNS cord-319448-gt6uqfrl 201 11 to to TO cord-319448-gt6uqfrl 201 12 validate validate VB cord-319448-gt6uqfrl 201 13 or or CC cord-319448-gt6uqfrl 201 14 refute refute VB cord-319448-gt6uqfrl 201 15 the the DT cord-319448-gt6uqfrl 201 16 framework framework NN cord-319448-gt6uqfrl 201 17 will will MD cord-319448-gt6uqfrl 201 18 undoubtedly undoubtedly RB cord-319448-gt6uqfrl 201 19 foster foster VB cord-319448-gt6uqfrl 201 20 research research NN cord-319448-gt6uqfrl 201 21 into into IN cord-319448-gt6uqfrl 201 22 improved improved JJ cord-319448-gt6uqfrl 201 23 measures measure NNS cord-319448-gt6uqfrl 201 24 of of IN cord-319448-gt6uqfrl 201 25 damage damage NN cord-319448-gt6uqfrl 201 26 and and CC cord-319448-gt6uqfrl 201 27 the the DT cord-319448-gt6uqfrl 201 28 immune immune JJ cord-319448-gt6uqfrl 201 29 response response NN cord-319448-gt6uqfrl 201 30 . . . cord-319448-gt6uqfrl 202 1 Second second RB cord-319448-gt6uqfrl 202 2 , , , cord-319448-gt6uqfrl 202 3 the the DT cord-319448-gt6uqfrl 202 4 framework framework NN cord-319448-gt6uqfrl 202 5 can can MD cord-319448-gt6uqfrl 202 6 lead lead VB cord-319448-gt6uqfrl 202 7 to to IN cord-319448-gt6uqfrl 202 8 predictions prediction NNS cord-319448-gt6uqfrl 202 9 that that WDT cord-319448-gt6uqfrl 202 10 might may MD cord-319448-gt6uqfrl 202 11 enhance enhance VB cord-319448-gt6uqfrl 202 12 the the DT cord-319448-gt6uqfrl 202 13 development development NN cord-319448-gt6uqfrl 202 14 and and CC cord-319448-gt6uqfrl 202 15 predictability predictability NN cord-319448-gt6uqfrl 203 1 The the DT cord-319448-gt6uqfrl 203 2 host host NN cord-319448-gt6uqfrl 203 3 - - HYPH cord-319448-gt6uqfrl 203 4 microorganism microorganism NN cord-319448-gt6uqfrl 203 5 interaction interaction NN cord-319448-gt6uqfrl 203 6 can can MD cord-319448-gt6uqfrl 203 7 be be VB cord-319448-gt6uqfrl 203 8 depicted depict VBN cord-319448-gt6uqfrl 203 9 by by IN cord-319448-gt6uqfrl 203 10 plotting plot VBG cord-319448-gt6uqfrl 203 11 host host NN cord-319448-gt6uqfrl 203 12 damage damage NN cord-319448-gt6uqfrl 203 13 as as IN cord-319448-gt6uqfrl 203 14 a a DT cord-319448-gt6uqfrl 203 15 function function NN cord-319448-gt6uqfrl 203 16 of of IN cord-319448-gt6uqfrl 203 17 time time NN cord-319448-gt6uqfrl 203 18 . . . cord-319448-gt6uqfrl 204 1 Panels panel NNS cord-319448-gt6uqfrl 204 2 a a DT cord-319448-gt6uqfrl 204 3 - - HYPH cord-319448-gt6uqfrl 204 4 d d NN cord-319448-gt6uqfrl 204 5 show show NN cord-319448-gt6uqfrl 204 6 how how WRB cord-319448-gt6uqfrl 204 7 plotting plot VBG cord-319448-gt6uqfrl 204 8 damage damage NN cord-319448-gt6uqfrl 204 9 versus versus IN cord-319448-gt6uqfrl 204 10 time time NN cord-319448-gt6uqfrl 204 11 can can MD cord-319448-gt6uqfrl 204 12 be be VB cord-319448-gt6uqfrl 204 13 used use VBN cord-319448-gt6uqfrl 204 14 to to TO cord-319448-gt6uqfrl 204 15 denote denote VB cord-319448-gt6uqfrl 204 16 the the DT cord-319448-gt6uqfrl 204 17 states state NNS cord-319448-gt6uqfrl 204 18 of of IN cord-319448-gt6uqfrl 204 19 the the DT cord-319448-gt6uqfrl 204 20 host host NN cord-319448-gt6uqfrl 204 21 - - HYPH cord-319448-gt6uqfrl 204 22 microorganism microorganism NN cord-319448-gt6uqfrl 204 23 interaction interaction NN cord-319448-gt6uqfrl 204 24 for for IN cord-319448-gt6uqfrl 204 25 four four CD cord-319448-gt6uqfrl 204 26 different different JJ cord-319448-gt6uqfrl 204 27 pathogens pathogen NNS cord-319448-gt6uqfrl 204 28 . . . cord-319448-gt6uqfrl 205 1 Infection infection NN cord-319448-gt6uqfrl 205 2 represents represent VBZ cord-319448-gt6uqfrl 205 3 the the DT cord-319448-gt6uqfrl 205 4 acquisition acquisition NN cord-319448-gt6uqfrl 205 5 of of IN cord-319448-gt6uqfrl 205 6 the the DT cord-319448-gt6uqfrl 205 7 microorganism microorganism NN cord-319448-gt6uqfrl 205 8 by by IN cord-319448-gt6uqfrl 205 9 the the DT cord-319448-gt6uqfrl 205 10 host host NN cord-319448-gt6uqfrl 205 11 and and CC cord-319448-gt6uqfrl 205 12 is be VBZ cord-319448-gt6uqfrl 205 13 followed follow VBN cord-319448-gt6uqfrl 205 14 by by IN cord-319448-gt6uqfrl 205 15 the the DT cord-319448-gt6uqfrl 205 16 states state NNS cord-319448-gt6uqfrl 205 17 of of IN cord-319448-gt6uqfrl 205 18 commensalism commensalism NN cord-319448-gt6uqfrl 205 19 , , , cord-319448-gt6uqfrl 205 20 colonization colonization NN cord-319448-gt6uqfrl 205 21 , , , cord-319448-gt6uqfrl 205 22 latency latency NN cord-319448-gt6uqfrl 205 23 and and CC cord-319448-gt6uqfrl 205 24 disease disease NN cord-319448-gt6uqfrl 205 25 , , , cord-319448-gt6uqfrl 205 26 depending depend VBG cord-319448-gt6uqfrl 205 27 on on IN cord-319448-gt6uqfrl 205 28 the the DT cord-319448-gt6uqfrl 205 29 amount amount NN cord-319448-gt6uqfrl 205 30 of of IN cord-319448-gt6uqfrl 205 31 damage damage NN cord-319448-gt6uqfrl 205 32 to to IN cord-319448-gt6uqfrl 205 33 the the DT cord-319448-gt6uqfrl 205 34 host host NN cord-319448-gt6uqfrl 205 35 2,5 2,5 CD cord-319448-gt6uqfrl 205 36 . . . cord-319448-gt6uqfrl 206 1 These these DT cord-319448-gt6uqfrl 206 2 plots plot NNS cord-319448-gt6uqfrl 206 3 highlight highlight VBP cord-319448-gt6uqfrl 206 4 the the DT cord-319448-gt6uqfrl 206 5 fact fact NN cord-319448-gt6uqfrl 206 6 that that IN cord-319448-gt6uqfrl 206 7 for for IN cord-319448-gt6uqfrl 206 8 certain certain JJ cord-319448-gt6uqfrl 206 9 pathogens pathogen NNS cord-319448-gt6uqfrl 206 10 there there EX cord-319448-gt6uqfrl 206 11 is be VBZ cord-319448-gt6uqfrl 206 12 continuity continuity NN cord-319448-gt6uqfrl 206 13 between between IN cord-319448-gt6uqfrl 206 14 the the DT cord-319448-gt6uqfrl 206 15 various various JJ cord-319448-gt6uqfrl 206 16 states state NNS cord-319448-gt6uqfrl 206 17 . . . cord-319448-gt6uqfrl 207 1 The the DT cord-319448-gt6uqfrl 207 2 colours colour NNS cord-319448-gt6uqfrl 207 3 green green JJ cord-319448-gt6uqfrl 207 4 , , , cord-319448-gt6uqfrl 207 5 yellow yellow JJ cord-319448-gt6uqfrl 207 6 and and CC cord-319448-gt6uqfrl 207 7 purple purple JJ cord-319448-gt6uqfrl 208 1 denote denote VB cord-319448-gt6uqfrl 208 2 health health NN cord-319448-gt6uqfrl 208 3 , , , cord-319448-gt6uqfrl 208 4 disease disease NN cord-319448-gt6uqfrl 208 5 and and CC cord-319448-gt6uqfrl 208 6 severe severe JJ cord-319448-gt6uqfrl 208 7 disease disease NN cord-319448-gt6uqfrl 208 8 , , , cord-319448-gt6uqfrl 208 9 respectively respectively RB cord-319448-gt6uqfrl 208 10 , , , cord-319448-gt6uqfrl 208 11 and and CC cord-319448-gt6uqfrl 208 12 the the DT cord-319448-gt6uqfrl 208 13 relevant relevant JJ cord-319448-gt6uqfrl 208 14 states state NNS cord-319448-gt6uqfrl 208 15 for for IN cord-319448-gt6uqfrl 208 16 each each DT cord-319448-gt6uqfrl 208 17 host host NN cord-319448-gt6uqfrl 208 18 - - HYPH cord-319448-gt6uqfrl 208 19 microorganism microorganism NN cord-319448-gt6uqfrl 208 20 interaction interaction NN cord-319448-gt6uqfrl 208 21 are be VBP cord-319448-gt6uqfrl 208 22 highlighted highlight VBN cord-319448-gt6uqfrl 208 23 in in IN cord-319448-gt6uqfrl 208 24 bold bold JJ cord-319448-gt6uqfrl 208 25 . . . cord-319448-gt6uqfrl 209 1 www.nature.com/reviews/micro www.nature.com/reviews/micro NNP cord-319448-gt6uqfrl 210 1 R r NN cord-319448-gt6uqfrl 210 2 E e NN cord-319448-gt6uqfrl 210 3 V v NN cord-319448-gt6uqfrl 211 1 I -PRON- PRP cord-319448-gt6uqfrl 211 2 E e NN cord-319448-gt6uqfrl 211 3 W w NN cord-319448-gt6uqfrl 211 4 S S NNP cord-319448-gt6uqfrl 211 5 blood blood NN cord-319448-gt6uqfrl 211 6 donors donor NNS cord-319448-gt6uqfrl 211 7 26 26 CD cord-319448-gt6uqfrl 211 8 . . . cord-319448-gt6uqfrl 212 1 Recently recently RB cord-319448-gt6uqfrl 212 2 , , , cord-319448-gt6uqfrl 212 3 several several JJ cord-319448-gt6uqfrl 212 4 countries country NNS cord-319448-gt6uqfrl 212 5 have have VBP cord-319448-gt6uqfrl 212 6 been be VBN cord-319448-gt6uqfrl 212 7 affected affect VBN cord-319448-gt6uqfrl 212 8 by by IN cord-319448-gt6uqfrl 212 9 coronavirus coronavirus NN cord-319448-gt6uqfrl 212 10 - - HYPH cord-319448-gt6uqfrl 212 11 associated associate VBN cord-319448-gt6uqfrl 212 12 SARS SARS NNP cord-319448-gt6uqfrl 212 13 19 19 CD cord-319448-gt6uqfrl 212 14 . . . cord-319448-gt6uqfrl 213 1 If if IN cord-319448-gt6uqfrl 213 2 disease disease NN cord-319448-gt6uqfrl 213 3 in in IN cord-319448-gt6uqfrl 213 4 SARS SARS NNP cord-319448-gt6uqfrl 213 5 is be VBZ cord-319448-gt6uqfrl 213 6 found find VBN cord-319448-gt6uqfrl 213 7 to to TO cord-319448-gt6uqfrl 213 8 be be VB cord-319448-gt6uqfrl 213 9 associated associate VBN cord-319448-gt6uqfrl 213 10 with with IN cord-319448-gt6uqfrl 213 11 a a DT cord-319448-gt6uqfrl 213 12 large large JJ cord-319448-gt6uqfrl 213 13 viral viral JJ cord-319448-gt6uqfrl 213 14 burden burden NN cord-319448-gt6uqfrl 213 15 , , , cord-319448-gt6uqfrl 213 16 it -PRON- PRP cord-319448-gt6uqfrl 213 17 might may MD cord-319448-gt6uqfrl 213 18 be be VB cord-319448-gt6uqfrl 213 19 anticipated anticipate VBN cord-319448-gt6uqfrl 213 20 that that IN cord-319448-gt6uqfrl 213 21 the the DT cord-319448-gt6uqfrl 213 22 process process NN cord-319448-gt6uqfrl 213 23 involves involve VBZ cord-319448-gt6uqfrl 213 24 viralmediated viralmediated JJ cord-319448-gt6uqfrl 213 25 damage damage NN cord-319448-gt6uqfrl 213 26 and and CC cord-319448-gt6uqfrl 213 27 that that IN cord-319448-gt6uqfrl 213 28 antiviral antiviral JJ cord-319448-gt6uqfrl 213 29 therapy therapy NN cord-319448-gt6uqfrl 213 30 could could MD cord-319448-gt6uqfrl 213 31 be be VB cord-319448-gt6uqfrl 213 32 helpful helpful JJ cord-319448-gt6uqfrl 213 33 therapeutically therapeutically RB cord-319448-gt6uqfrl 213 34 . . . cord-319448-gt6uqfrl 214 1 However however RB cord-319448-gt6uqfrl 214 2 , , , cord-319448-gt6uqfrl 214 3 if if IN cord-319448-gt6uqfrl 214 4 disease disease NN cord-319448-gt6uqfrl 214 5 is be VBZ cord-319448-gt6uqfrl 214 6 found find VBN cord-319448-gt6uqfrl 214 7 to to TO cord-319448-gt6uqfrl 214 8 be be VB cord-319448-gt6uqfrl 214 9 associated associate VBN cord-319448-gt6uqfrl 214 10 with with IN cord-319448-gt6uqfrl 214 11 inflammation inflammation NN cord-319448-gt6uqfrl 214 12 and and CC cord-319448-gt6uqfrl 214 13 a a DT cord-319448-gt6uqfrl 214 14 paucity paucity NN cord-319448-gt6uqfrl 214 15 or or CC cord-319448-gt6uqfrl 214 16 absence absence NN cord-319448-gt6uqfrl 214 17 of of IN cord-319448-gt6uqfrl 214 18 virus virus NN cord-319448-gt6uqfrl 214 19 in in IN cord-319448-gt6uqfrl 214 20 tissues tissue NNS cord-319448-gt6uqfrl 214 21 , , , cord-319448-gt6uqfrl 214 22 then then RB cord-319448-gt6uqfrl 214 23 the the DT cord-319448-gt6uqfrl 214 24 pathogenic pathogenic JJ cord-319448-gt6uqfrl 214 25 process process NN cord-319448-gt6uqfrl 214 26 might may MD cord-319448-gt6uqfrl 214 27 reflect reflect VB cord-319448-gt6uqfrl 214 28 immune immune JJ cord-319448-gt6uqfrl 214 29 - - HYPH cord-319448-gt6uqfrl 214 30 mediated mediate VBN cord-319448-gt6uqfrl 214 31 damage damage NN cord-319448-gt6uqfrl 214 32 for for IN cord-319448-gt6uqfrl 214 33 which which WDT cord-319448-gt6uqfrl 214 34 antiinflammatory antiinflammatory JJ cord-319448-gt6uqfrl 214 35 therapy therapy NN cord-319448-gt6uqfrl 214 36 could could MD cord-319448-gt6uqfrl 214 37 be be VB cord-319448-gt6uqfrl 214 38 helpful helpful JJ cord-319448-gt6uqfrl 214 39 . . . cord-319448-gt6uqfrl 215 1 Initial initial JJ cord-319448-gt6uqfrl 215 2 reports report NNS cord-319448-gt6uqfrl 215 3 that that IN cord-319448-gt6uqfrl 215 4 corticosteroid corticosteroid NN cord-319448-gt6uqfrl 215 5 therapy therapy NN cord-319448-gt6uqfrl 215 6 might may MD cord-319448-gt6uqfrl 215 7 be be VB cord-319448-gt6uqfrl 215 8 helpful helpful JJ cord-319448-gt6uqfrl 215 9 21 21 CD cord-319448-gt6uqfrl 215 10 are be VBP cord-319448-gt6uqfrl 215 11 consistent consistent JJ cord-319448-gt6uqfrl 215 12 with with IN cord-319448-gt6uqfrl 215 13 the the DT cord-319448-gt6uqfrl 215 14 possibility possibility NN cord-319448-gt6uqfrl 215 15 that that IN cord-319448-gt6uqfrl 215 16 host host NN cord-319448-gt6uqfrl 215 17 - - HYPH cord-319448-gt6uqfrl 215 18 mediated mediate VBN cord-319448-gt6uqfrl 215 19 damage damage NN cord-319448-gt6uqfrl 215 20 is be VBZ cord-319448-gt6uqfrl 215 21 responsible responsible JJ cord-319448-gt6uqfrl 215 22 for for IN cord-319448-gt6uqfrl 215 23 the the DT cord-319448-gt6uqfrl 215 24 disease disease NN cord-319448-gt6uqfrl 215 25 . . . cord-319448-gt6uqfrl 216 1 Fourth fourth RB cord-319448-gt6uqfrl 216 2 , , , cord-319448-gt6uqfrl 216 3 the the DT cord-319448-gt6uqfrl 216 4 damage damage NN cord-319448-gt6uqfrl 216 5 - - HYPH cord-319448-gt6uqfrl 216 6 response response NN cord-319448-gt6uqfrl 216 7 framework framework NN cord-319448-gt6uqfrl 216 8 promises promise VBZ cord-319448-gt6uqfrl 216 9 to to TO cord-319448-gt6uqfrl 216 10 be be VB cord-319448-gt6uqfrl 216 11 a a DT cord-319448-gt6uqfrl 216 12 useful useful JJ cord-319448-gt6uqfrl 216 13 educational educational JJ cord-319448-gt6uqfrl 216 14 tool tool NN cord-319448-gt6uqfrl 216 15 as as IN cord-319448-gt6uqfrl 216 16 it -PRON- PRP cord-319448-gt6uqfrl 216 17 avoids avoid VBZ cord-319448-gt6uqfrl 216 18 the the DT cord-319448-gt6uqfrl 216 19 ' ' `` cord-319448-gt6uqfrl 216 20 bug bug NN cord-319448-gt6uqfrl 216 21 parade parade NN cord-319448-gt6uqfrl 216 22 ' ' '' cord-319448-gt6uqfrl 216 23 that that WDT cord-319448-gt6uqfrl 216 24 students student NNS cord-319448-gt6uqfrl 216 25 of of IN cord-319448-gt6uqfrl 216 26 microbial microbial JJ cord-319448-gt6uqfrl 216 27 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 216 28 find find VBP cord-319448-gt6uqfrl 216 29 so so RB cord-319448-gt6uqfrl 216 30 unsatisfactory unsatisfactory JJ cord-319448-gt6uqfrl 216 31 , , , cord-319448-gt6uqfrl 216 32 and and CC cord-319448-gt6uqfrl 216 33 instead instead RB cord-319448-gt6uqfrl 216 34 provides provide VBZ cord-319448-gt6uqfrl 216 35 a a DT cord-319448-gt6uqfrl 216 36 more more RBR cord-319448-gt6uqfrl 216 37 straightforward straightforward JJ cord-319448-gt6uqfrl 216 38 classification classification NN cord-319448-gt6uqfrl 216 39 of of IN cord-319448-gt6uqfrl 216 40 pathogenic pathogenic JJ cord-319448-gt6uqfrl 216 41 microorganisms microorganism NNS cord-319448-gt6uqfrl 216 42 that that WDT cord-319448-gt6uqfrl 216 43 integrates integrate VBZ cord-319448-gt6uqfrl 216 44 the the DT cord-319448-gt6uqfrl 216 45 contributions contribution NNS cord-319448-gt6uqfrl 216 46 of of IN cord-319448-gt6uqfrl 216 47 both both DT cord-319448-gt6uqfrl 216 48 host host NN cord-319448-gt6uqfrl 216 49 and and CC cord-319448-gt6uqfrl 216 50 pathogen pathogen NN cord-319448-gt6uqfrl 216 51 . . . cord-319448-gt6uqfrl 217 1 Finally finally RB cord-319448-gt6uqfrl 217 2 , , , cord-319448-gt6uqfrl 217 3 the the DT cord-319448-gt6uqfrl 217 4 damage damage NN cord-319448-gt6uqfrl 217 5 - - HYPH cord-319448-gt6uqfrl 217 6 response response NN cord-319448-gt6uqfrl 217 7 framework framework NN cord-319448-gt6uqfrl 217 8 should should MD cord-319448-gt6uqfrl 217 9 provide provide VB cord-319448-gt6uqfrl 217 10 a a DT cord-319448-gt6uqfrl 217 11 mechanism mechanism NN cord-319448-gt6uqfrl 217 12 that that WDT cord-319448-gt6uqfrl 217 13 brings bring VBZ cord-319448-gt6uqfrl 217 14 together together RB cord-319448-gt6uqfrl 217 15 , , , cord-319448-gt6uqfrl 217 16 under under IN cord-319448-gt6uqfrl 217 17 one one CD cord-319448-gt6uqfrl 217 18 umbrella umbrella NN cord-319448-gt6uqfrl 217 19 , , , cord-319448-gt6uqfrl 217 20 the the DT cord-319448-gt6uqfrl 217 21 different different JJ cord-319448-gt6uqfrl 217 22 areas area NNS cord-319448-gt6uqfrl 217 23 of of IN cord-319448-gt6uqfrl 217 24 microbial microbial JJ cord-319448-gt6uqfrl 217 25 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 217 26 that that IN cord-319448-gt6uqfrl 217 27 , , , cord-319448-gt6uqfrl 217 28 at at IN cord-319448-gt6uqfrl 217 29 present present NN cord-319448-gt6uqfrl 217 30 , , , cord-319448-gt6uqfrl 217 31 are be VBP cord-319448-gt6uqfrl 217 32 isolated isolate VBN cord-319448-gt6uqfrl 217 33 from from IN cord-319448-gt6uqfrl 217 34 one one CD cord-319448-gt6uqfrl 217 35 another another DT cord-319448-gt6uqfrl 217 36 , , , cord-319448-gt6uqfrl 217 37 such such JJ cord-319448-gt6uqfrl 217 38 as as IN cord-319448-gt6uqfrl 217 39 viral viral JJ cord-319448-gt6uqfrl 217 40 and and CC cord-319448-gt6uqfrl 217 41 bacterial bacterial JJ cord-319448-gt6uqfrl 217 42 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 217 43 . . . cord-319448-gt6uqfrl 218 1 Such such JJ cord-319448-gt6uqfrl 218 2 an an DT cord-319448-gt6uqfrl 218 3 approach approach NN cord-319448-gt6uqfrl 218 4 would would MD cord-319448-gt6uqfrl 218 5 foster foster VB cord-319448-gt6uqfrl 218 6 collaboration collaboration NN cord-319448-gt6uqfrl 218 7 at at IN cord-319448-gt6uqfrl 218 8 all all PDT cord-319448-gt6uqfrl 218 9 the the DT cord-319448-gt6uqfrl 218 10 interfaces interface NNS cord-319448-gt6uqfrl 218 11 between between IN cord-319448-gt6uqfrl 218 12 microbiology microbiology NN cord-319448-gt6uqfrl 218 13 and and CC cord-319448-gt6uqfrl 218 14 immunology immunology NN cord-319448-gt6uqfrl 218 15 , , , cord-319448-gt6uqfrl 218 16 and and CC cord-319448-gt6uqfrl 218 17 ultimately ultimately RB cord-319448-gt6uqfrl 218 18 advance advance VB cord-319448-gt6uqfrl 218 19 our -PRON- PRP$ cord-319448-gt6uqfrl 218 20 understanding understanding NN cord-319448-gt6uqfrl 218 21 of of IN cord-319448-gt6uqfrl 218 22 infectious infectious JJ cord-319448-gt6uqfrl 218 23 diseases disease NNS cord-319448-gt6uqfrl 218 24 . . . cord-319448-gt6uqfrl 219 1 of of IN cord-319448-gt6uqfrl 219 2 rational rational JJ cord-319448-gt6uqfrl 219 3 vaccine vaccine NN cord-319448-gt6uqfrl 219 4 design design NN cord-319448-gt6uqfrl 219 5 . . . cord-319448-gt6uqfrl 220 1 Consider consider VB cord-319448-gt6uqfrl 220 2 TB TB NNP cord-319448-gt6uqfrl 220 3 , , , cord-319448-gt6uqfrl 220 4 a a DT cord-319448-gt6uqfrl 220 5 disease disease NN cord-319448-gt6uqfrl 220 6 for for IN cord-319448-gt6uqfrl 220 7 which which WDT cord-319448-gt6uqfrl 220 8 there there EX cord-319448-gt6uqfrl 220 9 has have VBZ cord-319448-gt6uqfrl 220 10 been be VBN cord-319448-gt6uqfrl 220 11 a a DT cord-319448-gt6uqfrl 220 12 major major JJ cord-319448-gt6uqfrl 220 13 effort effort NN cord-319448-gt6uqfrl 220 14 to to TO cord-319448-gt6uqfrl 220 15 develop develop VB cord-319448-gt6uqfrl 220 16 a a DT cord-319448-gt6uqfrl 220 17 vaccine vaccine NN cord-319448-gt6uqfrl 220 18 and/or and/or CC cord-319448-gt6uqfrl 220 19 immune immune NN cord-319448-gt6uqfrl 220 20 - - HYPH cord-319448-gt6uqfrl 220 21 based base VBN cord-319448-gt6uqfrl 220 22 therapy therapy NN cord-319448-gt6uqfrl 220 23 . . . cord-319448-gt6uqfrl 221 1 The the DT cord-319448-gt6uqfrl 221 2 causative causative JJ cord-319448-gt6uqfrl 221 3 agent agent NN cord-319448-gt6uqfrl 221 4 of of IN cord-319448-gt6uqfrl 221 5 TB TB NNP cord-319448-gt6uqfrl 221 6 , , , cord-319448-gt6uqfrl 221 7 Mycobacterium Mycobacterium NNP cord-319448-gt6uqfrl 221 8 tuberculosis tuberculosis NN cord-319448-gt6uqfrl 221 9 , , , cord-319448-gt6uqfrl 221 10 is be VBZ cord-319448-gt6uqfrl 221 11 a a DT cord-319448-gt6uqfrl 221 12 Class class NN cord-319448-gt6uqfrl 221 13 3 3 CD cord-319448-gt6uqfrl 221 14 pathogen pathogen NN cord-319448-gt6uqfrl 221 15 that that WDT cord-319448-gt6uqfrl 221 16 induces induce VBZ cord-319448-gt6uqfrl 221 17 damage damage NN cord-319448-gt6uqfrl 221 18 at at IN cord-319448-gt6uqfrl 221 19 the the DT cord-319448-gt6uqfrl 221 20 extremes extreme NNS cord-319448-gt6uqfrl 221 21 of of IN cord-319448-gt6uqfrl 221 22 the the DT cord-319448-gt6uqfrl 221 23 immune immune JJ cord-319448-gt6uqfrl 221 24 response response NN cord-319448-gt6uqfrl 221 25 . . . cord-319448-gt6uqfrl 222 1 In in IN cord-319448-gt6uqfrl 222 2 immunocompetent immunocompetent JJ cord-319448-gt6uqfrl 222 3 individuals individual NNS cord-319448-gt6uqfrl 222 4 , , , cord-319448-gt6uqfrl 222 5 damage damage NN cord-319448-gt6uqfrl 222 6 reflects reflect VBZ cord-319448-gt6uqfrl 222 7 a a DT cord-319448-gt6uqfrl 222 8 robust robust JJ cord-319448-gt6uqfrl 222 9 , , , cord-319448-gt6uqfrl 222 10 often often RB cord-319448-gt6uqfrl 222 11 helper helper NN cord-319448-gt6uqfrl 222 12 - - HYPH cord-319448-gt6uqfrl 222 13 T t NN cord-319448-gt6uqfrl 222 14 - - HYPH cord-319448-gt6uqfrl 222 15 cell-1-like cell-1-like NN cord-319448-gt6uqfrl 222 16 response response NN cord-319448-gt6uqfrl 222 17 , , , cord-319448-gt6uqfrl 222 18 whereas whereas IN cord-319448-gt6uqfrl 222 19 in in IN cord-319448-gt6uqfrl 222 20 immunocompromised immunocompromised JJ cord-319448-gt6uqfrl 222 21 individuals individual NNS cord-319448-gt6uqfrl 222 22 it -PRON- PRP cord-319448-gt6uqfrl 222 23 reflects reflect VBZ cord-319448-gt6uqfrl 222 24 an an DT cord-319448-gt6uqfrl 222 25 insufficient insufficient JJ cord-319448-gt6uqfrl 222 26 inflammatory inflammatory JJ cord-319448-gt6uqfrl 222 27 response response NN cord-319448-gt6uqfrl 222 28 . . . cord-319448-gt6uqfrl 223 1 As as IN cord-319448-gt6uqfrl 223 2 the the DT cord-319448-gt6uqfrl 223 3 basis basis NN cord-319448-gt6uqfrl 223 4 of of IN cord-319448-gt6uqfrl 223 5 host host NN cord-319448-gt6uqfrl 223 6 damage damage NN cord-319448-gt6uqfrl 223 7 differs differ VBZ cord-319448-gt6uqfrl 223 8 , , , cord-319448-gt6uqfrl 223 9 depending depend VBG cord-319448-gt6uqfrl 223 10 on on IN cord-319448-gt6uqfrl 223 11 the the DT cord-319448-gt6uqfrl 223 12 immune immune JJ cord-319448-gt6uqfrl 223 13 status status NN cord-319448-gt6uqfrl 223 14 of of IN cord-319448-gt6uqfrl 223 15 the the DT cord-319448-gt6uqfrl 223 16 individual individual NN cord-319448-gt6uqfrl 223 17 , , , cord-319448-gt6uqfrl 223 18 the the DT cord-319448-gt6uqfrl 223 19 damage damage NN cord-319448-gt6uqfrl 223 20 - - HYPH cord-319448-gt6uqfrl 223 21 response response NN cord-319448-gt6uqfrl 223 22 framework framework NN cord-319448-gt6uqfrl 223 23 would would MD cord-319448-gt6uqfrl 223 24 predict predict VB cord-319448-gt6uqfrl 223 25 that that IN cord-319448-gt6uqfrl 223 26 the the DT cord-319448-gt6uqfrl 223 27 use use NN cord-319448-gt6uqfrl 223 28 of of IN cord-319448-gt6uqfrl 223 29 different different JJ cord-319448-gt6uqfrl 223 30 types type NNS cord-319448-gt6uqfrl 223 31 of of IN cord-319448-gt6uqfrl 223 32 vaccines vaccine NNS cord-319448-gt6uqfrl 223 33 , , , cord-319448-gt6uqfrl 223 34 vaccine vaccine NN cord-319448-gt6uqfrl 223 35 antigens antigen NNS cord-319448-gt6uqfrl 223 36 or or CC cord-319448-gt6uqfrl 223 37 vaccination vaccination NN cord-319448-gt6uqfrl 223 38 strategies strategy NNS cord-319448-gt6uqfrl 223 39 might may MD cord-319448-gt6uqfrl 223 40 be be VB cord-319448-gt6uqfrl 223 41 necessary necessary JJ cord-319448-gt6uqfrl 223 42 to to TO cord-319448-gt6uqfrl 223 43 prevent prevent VB cord-319448-gt6uqfrl 223 44 TB TB NNP cord-319448-gt6uqfrl 223 45 in in IN cord-319448-gt6uqfrl 223 46 immunocompetent immunocompetent JJ cord-319448-gt6uqfrl 223 47 and and CC cord-319448-gt6uqfrl 223 48 immunocompromised immunocompromised JJ cord-319448-gt6uqfrl 223 49 individuals individual NNS cord-319448-gt6uqfrl 223 50 . . . cord-319448-gt6uqfrl 224 1 Similarly similarly RB cord-319448-gt6uqfrl 224 2 , , , cord-319448-gt6uqfrl 224 3 immune immune JJ cord-319448-gt6uqfrl 224 4 therapies therapy NNS cord-319448-gt6uqfrl 224 5 could could MD cord-319448-gt6uqfrl 224 6 be be VB cord-319448-gt6uqfrl 224 7 directed direct VBN cord-319448-gt6uqfrl 224 8 towards towards IN cord-319448-gt6uqfrl 224 9 reducing reduce VBG cord-319448-gt6uqfrl 224 10 the the DT cord-319448-gt6uqfrl 224 11 inflammatory inflammatory JJ cord-319448-gt6uqfrl 224 12 damage damage NN cord-319448-gt6uqfrl 224 13 in in IN cord-319448-gt6uqfrl 224 14 immunocompetent immunocompetent JJ cord-319448-gt6uqfrl 224 15 hosts host NNS cord-319448-gt6uqfrl 224 16 and and CC cord-319448-gt6uqfrl 224 17 enhancing enhance VBG cord-319448-gt6uqfrl 224 18 the the DT cord-319448-gt6uqfrl 224 19 immune immune JJ cord-319448-gt6uqfrl 224 20 function function NN cord-319448-gt6uqfrl 224 21 in in IN cord-319448-gt6uqfrl 224 22 immunocompromised immunocompromised JJ cord-319448-gt6uqfrl 224 23 hosts host NNS cord-319448-gt6uqfrl 224 24 . . . cord-319448-gt6uqfrl 225 1 Third third RB cord-319448-gt6uqfrl 225 2 , , , cord-319448-gt6uqfrl 225 3 the the DT cord-319448-gt6uqfrl 225 4 damage damage NN cord-319448-gt6uqfrl 225 5 - - HYPH cord-319448-gt6uqfrl 225 6 response response NN cord-319448-gt6uqfrl 225 7 framework framework NN cord-319448-gt6uqfrl 225 8 has have VBZ cord-319448-gt6uqfrl 225 9 the the DT cord-319448-gt6uqfrl 225 10 potential potential NN cord-319448-gt6uqfrl 225 11 to to TO cord-319448-gt6uqfrl 225 12 characterize characterize VB cord-319448-gt6uqfrl 225 13 new new JJ cord-319448-gt6uqfrl 225 14 and and CC cord-319448-gt6uqfrl 225 15 emerging emerge VBG cord-319448-gt6uqfrl 225 16 infectious infectious JJ cord-319448-gt6uqfrl 225 17 diseases disease NNS cord-319448-gt6uqfrl 225 18 , , , cord-319448-gt6uqfrl 225 19 thereby thereby RB cord-319448-gt6uqfrl 225 20 facilitating facilitate VBG cord-319448-gt6uqfrl 225 21 a a DT cord-319448-gt6uqfrl 225 22 more more RBR cord-319448-gt6uqfrl 225 23 rapid rapid JJ cord-319448-gt6uqfrl 225 24 and and CC cord-319448-gt6uqfrl 225 25 focused focused JJ cord-319448-gt6uqfrl 225 26 response response NN cord-319448-gt6uqfrl 225 27 by by IN cord-319448-gt6uqfrl 225 28 the the DT cord-319448-gt6uqfrl 225 29 public public JJ cord-319448-gt6uqfrl 225 30 authorities authority NNS cord-319448-gt6uqfrl 225 31 and and CC cord-319448-gt6uqfrl 225 32 research research NN cord-319448-gt6uqfrl 225 33 community community NN cord-319448-gt6uqfrl 225 34 . . . cord-319448-gt6uqfrl 226 1 Two two CD cord-319448-gt6uqfrl 226 2 recent recent JJ cord-319448-gt6uqfrl 226 3 emerging emerge VBG cord-319448-gt6uqfrl 226 4 infectious infectious JJ cord-319448-gt6uqfrl 226 5 diseases disease NNS cord-319448-gt6uqfrl 226 6 exemplify exemplify VBP cord-319448-gt6uqfrl 226 7 this this DT cord-319448-gt6uqfrl 226 8 point point NN cord-319448-gt6uqfrl 226 9 . . . cord-319448-gt6uqfrl 227 1 The the DT cord-319448-gt6uqfrl 227 2 recognition recognition NN cord-319448-gt6uqfrl 227 3 that that IN cord-319448-gt6uqfrl 227 4 the the DT cord-319448-gt6uqfrl 227 5 disease disease NN cord-319448-gt6uqfrl 227 6 - - HYPH cord-319448-gt6uqfrl 227 7 to to IN cord-319448-gt6uqfrl 227 8 - - HYPH cord-319448-gt6uqfrl 227 9 infection infection NN cord-319448-gt6uqfrl 227 10 ratio ratio NN cord-319448-gt6uqfrl 227 11 for for IN cord-319448-gt6uqfrl 227 12 West West NNP cord-319448-gt6uqfrl 227 13 Nile Nile NNP cord-319448-gt6uqfrl 227 14 virus virus NN cord-319448-gt6uqfrl 227 15 in in IN cord-319448-gt6uqfrl 227 16 endemic endemic JJ cord-319448-gt6uqfrl 227 17 areas area NNS cord-319448-gt6uqfrl 227 18 is be VBZ cord-319448-gt6uqfrl 227 19 very very RB cord-319448-gt6uqfrl 227 20 low low JJ cord-319448-gt6uqfrl 227 21 , , , cord-319448-gt6uqfrl 227 22 led lead VBD cord-319448-gt6uqfrl 227 23 to to IN cord-319448-gt6uqfrl 227 24 the the DT cord-319448-gt6uqfrl 227 25 successful successful JJ cord-319448-gt6uqfrl 227 26 experimental experimental JJ cord-319448-gt6uqfrl 227 27 use use NN cord-319448-gt6uqfrl 227 28 of of IN cord-319448-gt6uqfrl 227 29 passive passive JJ cord-319448-gt6uqfrl 227 30 antibody antibody NN cord-319448-gt6uqfrl 227 31 therapy therapy NN cord-319448-gt6uqfrl 227 32 with with IN cord-319448-gt6uqfrl 227 33 immunoglobulins immunoglobulin NNS cord-319448-gt6uqfrl 227 34 from from IN cord-319448-gt6uqfrl 227 35 asymptomatic asymptomatic JJ cord-319448-gt6uqfrl 227 36 Introduces introduce VBZ cord-319448-gt6uqfrl 227 37 the the DT cord-319448-gt6uqfrl 227 38 ' ' `` cord-319448-gt6uqfrl 227 39 damage damage NN cord-319448-gt6uqfrl 227 40 - - HYPH cord-319448-gt6uqfrl 227 41 response response NN cord-319448-gt6uqfrl 227 42 ' ' '' cord-319448-gt6uqfrl 227 43 framework framework NN cord-319448-gt6uqfrl 227 44 and and CC cord-319448-gt6uqfrl 227 45 proposes propose VBZ cord-319448-gt6uqfrl 227 46 a a DT cord-319448-gt6uqfrl 227 47 new new JJ cord-319448-gt6uqfrl 227 48 classification classification NN cord-319448-gt6uqfrl 227 49 for for IN cord-319448-gt6uqfrl 227 50 pathogens pathogen NNS cord-319448-gt6uqfrl 227 51 based base VBN cord-319448-gt6uqfrl 227 52 on on IN cord-319448-gt6uqfrl 227 53 their -PRON- PRP$ cord-319448-gt6uqfrl 227 54 ability ability NN cord-319448-gt6uqfrl 227 55 to to TO cord-319448-gt6uqfrl 227 56 damage damage VB cord-319448-gt6uqfrl 227 57 the the DT cord-319448-gt6uqfrl 227 58 host host NN cord-319448-gt6uqfrl 227 59 as as IN cord-319448-gt6uqfrl 227 60 a a DT cord-319448-gt6uqfrl 227 61 function function NN cord-319448-gt6uqfrl 227 62 of of IN cord-319448-gt6uqfrl 227 63 the the DT cord-319448-gt6uqfrl 227 64 host host NN cord-319448-gt6uqfrl 227 65 response response NN cord-319448-gt6uqfrl 227 66 Expands expand VBZ cord-319448-gt6uqfrl 227 67 the the DT cord-319448-gt6uqfrl 227 68 ' ' `` cord-319448-gt6uqfrl 227 69 damage damage NN cord-319448-gt6uqfrl 227 70 - - HYPH cord-319448-gt6uqfrl 227 71 response response NN cord-319448-gt6uqfrl 227 72 ' ' '' cord-319448-gt6uqfrl 227 73 framework framework NN cord-319448-gt6uqfrl 227 74 to to TO cord-319448-gt6uqfrl 227 75 incorporate incorporate VB cord-319448-gt6uqfrl 227 76 the the DT cord-319448-gt6uqfrl 227 77 variable variable NN cord-319448-gt6uqfrl 227 78 of of IN cord-319448-gt6uqfrl 227 79 time time NN cord-319448-gt6uqfrl 227 80 and and CC cord-319448-gt6uqfrl 227 81 proposes propose VBZ cord-319448-gt6uqfrl 227 82 that that IN cord-319448-gt6uqfrl 227 83 the the DT cord-319448-gt6uqfrl 227 84 outcome outcome NN cord-319448-gt6uqfrl 227 85 of of IN cord-319448-gt6uqfrl 227 86 the the DT cord-319448-gt6uqfrl 227 87 host host NN cord-319448-gt6uqfrl 227 88 - - HYPH cord-319448-gt6uqfrl 227 89 microorganism microorganism NN cord-319448-gt6uqfrl 227 90 interaction interaction NN cord-319448-gt6uqfrl 227 91 can can MD cord-319448-gt6uqfrl 227 92 be be VB cord-319448-gt6uqfrl 227 93 reduced reduce VBN cord-319448-gt6uqfrl 227 94 to to IN cord-319448-gt6uqfrl 227 95 four four CD cord-319448-gt6uqfrl 227 96 states state NNS cord-319448-gt6uqfrl 227 97 that that WDT cord-319448-gt6uqfrl 227 98 differ differ VBP cord-319448-gt6uqfrl 227 99 in in IN cord-319448-gt6uqfrl 227 100 the the DT cord-319448-gt6uqfrl 227 101 amount amount NN cord-319448-gt6uqfrl 227 102 of of IN cord-319448-gt6uqfrl 227 103 damage damage NN cord-319448-gt6uqfrl 227 104 incurred incur VBN cord-319448-gt6uqfrl 227 105 by by IN cord-319448-gt6uqfrl 227 106 the the DT cord-319448-gt6uqfrl 227 107 host host NN cord-319448-gt6uqfrl 227 108 as as IN cord-319448-gt6uqfrl 227 109 a a DT cord-319448-gt6uqfrl 227 110 function function NN cord-319448-gt6uqfrl 227 111 of of IN cord-319448-gt6uqfrl 227 112 time time NN cord-319448-gt6uqfrl 227 113 What what WP cord-319448-gt6uqfrl 227 114 is be VBZ cord-319448-gt6uqfrl 227 115 a a DT cord-319448-gt6uqfrl 227 116 pathogen pathogen NN cord-319448-gt6uqfrl 227 117 ? ? . cord-319448-gt6uqfrl 228 1 Discusses discusse NNS cord-319448-gt6uqfrl 229 1 limitations limitation NNS cord-319448-gt6uqfrl 229 2 of of IN cord-319448-gt6uqfrl 229 3 the the DT cord-319448-gt6uqfrl 229 4 existing exist VBG cord-319448-gt6uqfrl 229 5 concepts concept NNS cord-319448-gt6uqfrl 229 6 of of IN cord-319448-gt6uqfrl 229 7 virulence virulence NN cord-319448-gt6uqfrl 229 8 and and CC cord-319448-gt6uqfrl 229 9 problems problem NNS cord-319448-gt6uqfrl 229 10 with with IN cord-319448-gt6uqfrl 229 11 definitions definition NNS cord-319448-gt6uqfrl 229 12 of of IN cord-319448-gt6uqfrl 229 13 virulence virulence NN cord-319448-gt6uqfrl 229 14 factors factor NNS cord-319448-gt6uqfrl 229 15 Highlights highlight VBZ cord-319448-gt6uqfrl 229 16 how how WRB cord-319448-gt6uqfrl 229 17 the the DT cord-319448-gt6uqfrl 229 18 damage damage NN cord-319448-gt6uqfrl 229 19 - - HYPH cord-319448-gt6uqfrl 229 20 response response NN cord-319448-gt6uqfrl 229 21 framework framework NN cord-319448-gt6uqfrl 229 22 can can MD cord-319448-gt6uqfrl 229 23 be be VB cord-319448-gt6uqfrl 229 24 used use VBN cord-319448-gt6uqfrl 229 25 to to TO cord-319448-gt6uqfrl 229 26 classify classify VB cord-319448-gt6uqfrl 229 27 the the DT cord-319448-gt6uqfrl 229 28 host host NN cord-319448-gt6uqfrl 229 29 - - HYPH cord-319448-gt6uqfrl 229 30 microorganism microorganism NN cord-319448-gt6uqfrl 229 31 interaction interaction NN cord-319448-gt6uqfrl 229 32 in in IN cord-319448-gt6uqfrl 229 33 clinical clinical JJ cord-319448-gt6uqfrl 229 34 practice practice NN cord-319448-gt6uqfrl 230 1 On on IN cord-319448-gt6uqfrl 230 2 the the DT cord-319448-gt6uqfrl 230 3 definition definition NN cord-319448-gt6uqfrl 230 4 of of IN cord-319448-gt6uqfrl 230 5 virulence virulence NN cord-319448-gt6uqfrl 230 6 The the DT cord-319448-gt6uqfrl 230 7 origin origin NN cord-319448-gt6uqfrl 230 8 of of IN cord-319448-gt6uqfrl 230 9 plant plant NN cord-319448-gt6uqfrl 230 10 and and CC cord-319448-gt6uqfrl 230 11 animal animal NN cord-319448-gt6uqfrl 230 12 cells cell NNS cord-319448-gt6uqfrl 231 1 Symbiosis symbiosis NN cord-319448-gt6uqfrl 231 2 and and CC cord-319448-gt6uqfrl 231 3 evolution evolution NN cord-319448-gt6uqfrl 231 4 Principles Principles NNPS cord-319448-gt6uqfrl 231 5 and and CC cord-319448-gt6uqfrl 231 6 Practice practice NN cord-319448-gt6uqfrl 231 7 of of IN cord-319448-gt6uqfrl 231 8 Infectious Infectious NNP cord-319448-gt6uqfrl 231 9 Diseases Diseases NNPS cord-319448-gt6uqfrl 231 10 Legionella Legionella NNP cord-319448-gt6uqfrl 231 11 pneumophila pneumophila NN cord-319448-gt6uqfrl 231 12 pathogenesis pathogenesis NN cord-319448-gt6uqfrl 231 13 : : : cord-319448-gt6uqfrl 231 14 a a DT cord-319448-gt6uqfrl 231 15 fateful fateful JJ cord-319448-gt6uqfrl 231 16 journey journey NN cord-319448-gt6uqfrl 231 17 from from IN cord-319448-gt6uqfrl 231 18 amoebae amoebae NN cord-319448-gt6uqfrl 231 19 to to IN cord-319448-gt6uqfrl 231 20 macrophages macrophage NNS cord-319448-gt6uqfrl 232 1 Cryptococcus Cryptococcus NNP cord-319448-gt6uqfrl 232 2 neoformans neoforman VBZ cord-319448-gt6uqfrl 232 3 interactions interaction NNS cord-319448-gt6uqfrl 232 4 with with IN cord-319448-gt6uqfrl 232 5 amoebae amoeba NNS cord-319448-gt6uqfrl 232 6 suggest suggest VBP cord-319448-gt6uqfrl 232 7 an an DT cord-319448-gt6uqfrl 232 8 explanation explanation NN cord-319448-gt6uqfrl 232 9 for for IN cord-319448-gt6uqfrl 232 10 its -PRON- PRP$ cord-319448-gt6uqfrl 232 11 virulence virulence NN cord-319448-gt6uqfrl 232 12 and and CC cord-319448-gt6uqfrl 232 13 intracellular intracellular JJ cord-319448-gt6uqfrl 232 14 pathogenic pathogenic JJ cord-319448-gt6uqfrl 232 15 strategy strategy NN cord-319448-gt6uqfrl 232 16 in in IN cord-319448-gt6uqfrl 232 17 macrophages macrophage NNS cord-319448-gt6uqfrl 232 18 Common common JJ cord-319448-gt6uqfrl 232 19 themes theme NNS cord-319448-gt6uqfrl 232 20 in in IN cord-319448-gt6uqfrl 232 21 microbial microbial JJ cord-319448-gt6uqfrl 232 22 pathogenicity pathogenicity NN cord-319448-gt6uqfrl 232 23 revisited revisit VBN cord-319448-gt6uqfrl 232 24 . . . cord-319448-gt6uqfrl 233 1 Microbiol Microbiol NNP cord-319448-gt6uqfrl 233 2 Pathogenicity Pathogenicity NNP cord-319448-gt6uqfrl 233 3 islands island NNS cord-319448-gt6uqfrl 233 4 of of IN cord-319448-gt6uqfrl 233 5 virulent virulent JJ cord-319448-gt6uqfrl 233 6 bacteria bacteria NNS cord-319448-gt6uqfrl 233 7 : : : cord-319448-gt6uqfrl 233 8 structure structure NN cord-319448-gt6uqfrl 233 9 , , , cord-319448-gt6uqfrl 233 10 function function NN cord-319448-gt6uqfrl 233 11 and and CC cord-319448-gt6uqfrl 233 12 impact impact NN cord-319448-gt6uqfrl 233 13 on on IN cord-319448-gt6uqfrl 233 14 microbial microbial JJ cord-319448-gt6uqfrl 233 15 evolution evolution NN cord-319448-gt6uqfrl 233 16 Landmark Landmark NNP cord-319448-gt6uqfrl 233 17 paper paper NN cord-319448-gt6uqfrl 233 18 that that WDT cord-319448-gt6uqfrl 233 19 proposed propose VBD cord-319448-gt6uqfrl 233 20 a a DT cord-319448-gt6uqfrl 233 21 rigorous rigorous JJ cord-319448-gt6uqfrl 233 22 approach approach NN cord-319448-gt6uqfrl 233 23 to to IN cord-319448-gt6uqfrl 233 24 establishing establish VBG cord-319448-gt6uqfrl 233 25 whether whether IN cord-319448-gt6uqfrl 233 26 a a DT cord-319448-gt6uqfrl 233 27 gene gene NN cord-319448-gt6uqfrl 233 28 was be VBD cord-319448-gt6uqfrl 233 29 involved involve VBN cord-319448-gt6uqfrl 233 30 in in IN cord-319448-gt6uqfrl 233 31 microbial microbial JJ cord-319448-gt6uqfrl 233 32 virulence virulence NN cord-319448-gt6uqfrl 233 33 The the DT cord-319448-gt6uqfrl 233 34 role role NN cord-319448-gt6uqfrl 233 35 of of IN cord-319448-gt6uqfrl 233 36 opportunistic opportunistic JJ cord-319448-gt6uqfrl 233 37 bacteria bacteria NNS cord-319448-gt6uqfrl 233 38 in in IN cord-319448-gt6uqfrl 233 39 human human JJ cord-319448-gt6uqfrl 233 40 disease disease NN cord-319448-gt6uqfrl 233 41 History history NN cord-319448-gt6uqfrl 233 42 of of IN cord-319448-gt6uqfrl 233 43 opportunistic opportunistic JJ cord-319448-gt6uqfrl 233 44 infection infection NN cord-319448-gt6uqfrl 233 45 in in IN cord-319448-gt6uqfrl 233 46 the the DT cord-319448-gt6uqfrl 233 47 immunocompromised immunocompromised JJ cord-319448-gt6uqfrl 233 48 host host NN cord-319448-gt6uqfrl 233 49 An an DT cord-319448-gt6uqfrl 233 50 informative informative JJ cord-319448-gt6uqfrl 233 51 story story NN cord-319448-gt6uqfrl 233 52 of of IN cord-319448-gt6uqfrl 233 53 how how WRB cord-319448-gt6uqfrl 233 54 the the DT cord-319448-gt6uqfrl 233 55 concept concept NN cord-319448-gt6uqfrl 233 56 of of IN cord-319448-gt6uqfrl 233 57 microbial microbial JJ cord-319448-gt6uqfrl 233 58 opportunism opportunism NN cord-319448-gt6uqfrl 233 59 evolved evolve VBN cord-319448-gt6uqfrl 233 60 in in IN cord-319448-gt6uqfrl 233 61 clinical clinical JJ cord-319448-gt6uqfrl 233 62 practice practice NN cord-319448-gt6uqfrl 233 63 Pathogenicity Pathogenicity NNP cord-319448-gt6uqfrl 233 64 and and CC cord-319448-gt6uqfrl 233 65 virulence virulence NN cord-319448-gt6uqfrl 233 66 : : : cord-319448-gt6uqfrl 233 67 another another DT cord-319448-gt6uqfrl 233 68 view view NN cord-319448-gt6uqfrl 233 69 An an DT cord-319448-gt6uqfrl 233 70 excellent excellent JJ cord-319448-gt6uqfrl 233 71 discussion discussion NN cord-319448-gt6uqfrl 233 72 of of IN cord-319448-gt6uqfrl 233 73 the the DT cord-319448-gt6uqfrl 233 74 limitations limitation NNS cord-319448-gt6uqfrl 233 75 of of IN cord-319448-gt6uqfrl 233 76 Koch Koch NNP cord-319448-gt6uqfrl 233 77 's 's POS cord-319448-gt6uqfrl 233 78 postulates postulate NNS cord-319448-gt6uqfrl 233 79 Exploiting exploit VBG cord-319448-gt6uqfrl 233 80 the the DT cord-319448-gt6uqfrl 233 81 redundancy redundancy NN cord-319448-gt6uqfrl 233 82 of of IN cord-319448-gt6uqfrl 233 83 the the DT cord-319448-gt6uqfrl 233 84 immune immune JJ cord-319448-gt6uqfrl 233 85 system system NN cord-319448-gt6uqfrl 233 86 : : : cord-319448-gt6uqfrl 233 87 vaccines vaccine NNS cord-319448-gt6uqfrl 233 88 can can MD cord-319448-gt6uqfrl 233 89 mediate mediate VB cord-319448-gt6uqfrl 233 90 protection protection NN cord-319448-gt6uqfrl 233 91 by by IN cord-319448-gt6uqfrl 233 92 eliciting elicit VBG cord-319448-gt6uqfrl 233 93 ' ' `` cord-319448-gt6uqfrl 233 94 unnatural unnatural JJ cord-319448-gt6uqfrl 233 95 ' ' '' cord-319448-gt6uqfrl 233 96 immunity immunity NN cord-319448-gt6uqfrl 233 97 Ribosomal Ribosomal NNP cord-319448-gt6uqfrl 233 98 RNA RNA NNP cord-319448-gt6uqfrl 233 99 shows show VBZ cord-319448-gt6uqfrl 233 100 Pneumocystis Pneumocystis NNP cord-319448-gt6uqfrl 233 101 carinii carinii FW cord-319448-gt6uqfrl 233 102 to to TO cord-319448-gt6uqfrl 233 103 be be VB cord-319448-gt6uqfrl 233 104 a a DT cord-319448-gt6uqfrl 233 105 member member NN cord-319448-gt6uqfrl 233 106 of of IN cord-319448-gt6uqfrl 233 107 the the DT cord-319448-gt6uqfrl 233 108 fungi fungus NNS cord-319448-gt6uqfrl 233 109 Antimicrobial Antimicrobial NNP cord-319448-gt6uqfrl 233 110 therapy therapy NN cord-319448-gt6uqfrl 233 111 Severe severe JJ cord-319448-gt6uqfrl 233 112 acute acute JJ cord-319448-gt6uqfrl 233 113 respiratory respiratory JJ cord-319448-gt6uqfrl 233 114 syndrome syndrome NN cord-319448-gt6uqfrl 233 115 ( ( -LRB- cord-319448-gt6uqfrl 233 116 SARS SARS NNP cord-319448-gt6uqfrl 233 117 ) ) -RRB- cord-319448-gt6uqfrl 233 118 : : : cord-319448-gt6uqfrl 234 1 breath breath NN cord-319448-gt6uqfrl 234 2 - - HYPH cord-319448-gt6uqfrl 234 3 taking take VBG cord-319448-gt6uqfrl 234 4 progress progress NN cord-319448-gt6uqfrl 234 5 Saccharomyces saccharomyce NNS cord-319448-gt6uqfrl 234 6 cerevisiae cerevisiae NNS cord-319448-gt6uqfrl 234 7 bacteremia bacteremia NN cord-319448-gt6uqfrl 234 8 A a DT cord-319448-gt6uqfrl 234 9 Saccharomyces Saccharomyces NNP cord-319448-gt6uqfrl 234 10 cerevisiae cerevisiae NNS cord-319448-gt6uqfrl 234 11 mutant mutant JJ cord-319448-gt6uqfrl 234 12 with with IN cord-319448-gt6uqfrl 234 13 increased increase VBN cord-319448-gt6uqfrl 234 14 virulence virulence NN cord-319448-gt6uqfrl 234 15 Parasitealtered Parasitealtered NNP cord-319448-gt6uqfrl 234 16 behaviour behaviour NN cord-319448-gt6uqfrl 234 17 : : : cord-319448-gt6uqfrl 234 18 is be VBZ cord-319448-gt6uqfrl 234 19 the the DT cord-319448-gt6uqfrl 234 20 effect effect NN cord-319448-gt6uqfrl 234 21 of of IN cord-319448-gt6uqfrl 234 22 Toxoplasma toxoplasma JJ cord-319448-gt6uqfrl 234 23 gondii gondii NN cord-319448-gt6uqfrl 234 24 on on IN cord-319448-gt6uqfrl 234 25 Rattus Rattus NNP cord-319448-gt6uqfrl 234 26 norvegicus norvegicus NN cord-319448-gt6uqfrl 234 27 specific specific JJ cord-319448-gt6uqfrl 234 28 ? ? . cord-319448-gt6uqfrl 235 1 dendritic dendritic JJ cord-319448-gt6uqfrl 235 2 cells cell NNS cord-319448-gt6uqfrl 235 3 and and CC cord-319448-gt6uqfrl 235 4 receptors receptor NNS cord-319448-gt6uqfrl 235 5 : : : cord-319448-gt6uqfrl 235 6 a a DT cord-319448-gt6uqfrl 235 7 host host NN cord-319448-gt6uqfrl 235 8 perspective perspective NN cord-319448-gt6uqfrl 235 9 of of IN cord-319448-gt6uqfrl 235 10 fungal fungal JJ cord-319448-gt6uqfrl 235 11 virulence virulence NN cord-319448-gt6uqfrl 235 12 Prophylactic prophylactic JJ cord-319448-gt6uqfrl 235 13 and and CC cord-319448-gt6uqfrl 235 14 therapeutic therapeutic JJ cord-319448-gt6uqfrl 235 15 efficacy efficacy NN cord-319448-gt6uqfrl 235 16 of of IN cord-319448-gt6uqfrl 235 17 human human JJ cord-319448-gt6uqfrl 235 18 intravenous intravenous JJ cord-319448-gt6uqfrl 235 19 immunoglobulin immunoglobulin NN cord-319448-gt6uqfrl 235 20 in in IN cord-319448-gt6uqfrl 235 21 treating treat VBG cord-319448-gt6uqfrl 235 22 west west NNP cord-319448-gt6uqfrl 235 23 nile nile NNP cord-319448-gt6uqfrl 235 24 virus virus NN cord-319448-gt6uqfrl 235 25 infection infection NN cord-319448-gt6uqfrl 235 26 in in IN cord-319448-gt6uqfrl 235 27 mice mouse NNS cord-319448-gt6uqfrl 235 28 Colonization Colonization NNP cord-319448-gt6uqfrl 235 29 with with IN cord-319448-gt6uqfrl 235 30 cagA caga JJ cord-319448-gt6uqfrl 235 31 - - HYPH cord-319448-gt6uqfrl 235 32 positive positive JJ cord-319448-gt6uqfrl 235 33 Helicobacter Helicobacter NNP cord-319448-gt6uqfrl 235 34 pylori pylori NN cord-319448-gt6uqfrl 235 35 strains strain NNS cord-319448-gt6uqfrl 235 36 inversely inversely RB cord-319448-gt6uqfrl 235 37 associated associate VBN cord-319448-gt6uqfrl 235 38 with with IN cord-319448-gt6uqfrl 235 39 reflux reflux NN cord-319448-gt6uqfrl 235 40 esophagitis esophagitis NN cord-319448-gt6uqfrl 235 41 and and CC cord-319448-gt6uqfrl 235 42 Barrett Barrett NNP cord-319448-gt6uqfrl 235 43 's 's POS cord-319448-gt6uqfrl 235 44 esophagus esophagus NN cord-319448-gt6uqfrl 236 1 The the DT cord-319448-gt6uqfrl 236 2 following follow VBG cord-319448-gt6uqfrl 236 3 terms term NNS cord-319448-gt6uqfrl 236 4 in in IN cord-319448-gt6uqfrl 236 5 this this DT cord-319448-gt6uqfrl 236 6 article article NN cord-319448-gt6uqfrl 236 7 are be VBP cord-319448-gt6uqfrl 236 8 linked link VBN cord-319448-gt6uqfrl 236 9 online online RB cord-319448-gt6uqfrl 236 10 to to IN cord-319448-gt6uqfrl 236 11 : : : cord-319448-gt6uqfrl 236 12 Infectious Infectious NNP cord-319448-gt6uqfrl 236 13 Disease Disease NNP cord-319448-gt6uqfrl 236 14 Information information NN cord-319448-gt6uqfrl 236 15 : : : cord-319448-gt6uqfrl 236 16 http://www.cdc.gov/ncidod/diseases/index.htm http://www.cdc.gov/ncidod/diseases/index.htm ADD cord-319448-gt6uqfrl 237 1 candidiasis candidiasis NN cord-319448-gt6uqfrl 237 2 | | NNP cord-319448-gt6uqfrl 237 3 Cryptococcus Cryptococcus NNP cord-319448-gt6uqfrl 237 4 neoformans neoforman VBZ cord-319448-gt6uqfrl 237 5 | | NNP cord-319448-gt6uqfrl 238 1 cysticercosis cysticercosis NNP cord-319448-gt6uqfrl 238 2 | | NNP cord-319448-gt6uqfrl 238 3 Legionella Legionella NNP cord-319448-gt6uqfrl 239 1 pneumophila pneumophila NNP cord-319448-gt6uqfrl 239 2 | | NNP cord-319448-gt6uqfrl 239 3 meningitis meningitis NN cord-319448-gt6uqfrl 239 4 | | HYPH cord-319448-gt6uqfrl 239 5 Mycoplasma Mycoplasma NNP cord-319448-gt6uqfrl 239 6 pneumonia pneumonia NN cord-319448-gt6uqfrl 239 7 | | : cord-319448-gt6uqfrl 239 8 Pneumocystis Pneumocystis NNP cord-319448-gt6uqfrl 239 9 carinii carinii FW cord-319448-gt6uqfrl 239 10 pneumonia pneumonia NN cord-319448-gt6uqfrl 239 11 | | : cord-319448-gt6uqfrl 239 12 syphilis syphili NNS cord-319448-gt6uqfrl 239 13 | | NNP cord-319448-gt6uqfrl 239 14 tuberculosis tuberculosis NN cord-319448-gt6uqfrl 239 15 Access Access NNP cord-319448-gt6uqfrl 239 16 to to IN cord-319448-gt6uqfrl 239 17 this this DT cord-319448-gt6uqfrl 239 18 interactive interactive JJ cord-319448-gt6uqfrl 239 19 links link NNS cord-319448-gt6uqfrl 239 20 box box NN cord-319448-gt6uqfrl 239 21 is be VBZ cord-319448-gt6uqfrl 239 22 free free JJ cord-319448-gt6uqfrl 239 23 online online RB cord-319448-gt6uqfrl 239 24 . . .