id sid tid token lemma pos cord-291946-kq0rsuxj 1 1 key key NN cord-291946-kq0rsuxj 1 2 : : : cord-291946-kq0rsuxj 1 3 cord-291946-kq0rsuxj cord-291946-kq0rsuxj . cord-291946-kq0rsuxj 2 1 authors author NNS cord-291946-kq0rsuxj 2 2 : : : cord-291946-kq0rsuxj 2 3 Etienne Etienne NNP cord-291946-kq0rsuxj 2 4 , , , cord-291946-kq0rsuxj 2 5 Lucie Lucie NNP cord-291946-kq0rsuxj 2 6 ; ; : cord-291946-kq0rsuxj 2 7 Emerman Emerman NNP cord-291946-kq0rsuxj 2 8 , , , cord-291946-kq0rsuxj 2 9 Michael Michael NNP cord-291946-kq0rsuxj 2 10 title title NN cord-291946-kq0rsuxj 2 11 : : : cord-291946-kq0rsuxj 2 12 The the DT cord-291946-kq0rsuxj 2 13 Mongoose Mongoose NNP cord-291946-kq0rsuxj 2 14 , , , cord-291946-kq0rsuxj 2 15 the the DT cord-291946-kq0rsuxj 2 16 Pheasant Pheasant NNP cord-291946-kq0rsuxj 2 17 , , , cord-291946-kq0rsuxj 2 18 the the DT cord-291946-kq0rsuxj 2 19 Pox Pox NNP cord-291946-kq0rsuxj 2 20 , , , cord-291946-kq0rsuxj 2 21 and and CC cord-291946-kq0rsuxj 2 22 the the DT cord-291946-kq0rsuxj 2 23 Retrovirus Retrovirus NNP cord-291946-kq0rsuxj 2 24 date date NN cord-291946-kq0rsuxj 2 25 : : : cord-291946-kq0rsuxj 2 26 2013 2013 CD cord-291946-kq0rsuxj 2 27 - - SYM cord-291946-kq0rsuxj 2 28 08 08 CD cord-291946-kq0rsuxj 2 29 - - HYPH cord-291946-kq0rsuxj 2 30 27 27 CD cord-291946-kq0rsuxj 2 31 journal journal NN cord-291946-kq0rsuxj 2 32 : : : cord-291946-kq0rsuxj 3 1 PLoS PLoS NNP cord-291946-kq0rsuxj 3 2 Biol Biol NNP cord-291946-kq0rsuxj 3 3 DOI DOI NNP cord-291946-kq0rsuxj 3 4 : : : cord-291946-kq0rsuxj 3 5 10.1371 10.1371 CD cord-291946-kq0rsuxj 3 6 / / SYM cord-291946-kq0rsuxj 3 7 journal.pbio.1001641 journal.pbio.1001641 NNP cord-291946-kq0rsuxj 3 8 sha sha NNP cord-291946-kq0rsuxj 3 9 : : : cord-291946-kq0rsuxj 3 10 06c172a11ee30931ac537dfb70ce020dced50918 06c172a11ee30931ac537dfb70ce020dced50918 . cord-291946-kq0rsuxj 4 1 doc_id doc_id CD cord-291946-kq0rsuxj 4 2 : : : cord-291946-kq0rsuxj 4 3 291946 291946 CD cord-291946-kq0rsuxj 4 4 cord_uid cord_uid NNS cord-291946-kq0rsuxj 4 5 : : : cord-291946-kq0rsuxj 5 1 kq0rsuxj kq0rsuxj NNP cord-291946-kq0rsuxj 6 1 Paleovirology paleovirology NN cord-291946-kq0rsuxj 6 2 is be VBZ cord-291946-kq0rsuxj 6 3 the the DT cord-291946-kq0rsuxj 6 4 study study NN cord-291946-kq0rsuxj 6 5 of of IN cord-291946-kq0rsuxj 6 6 ancient ancient JJ cord-291946-kq0rsuxj 6 7 viruses virus NNS cord-291946-kq0rsuxj 6 8 . . . cord-291946-kq0rsuxj 7 1 The the DT cord-291946-kq0rsuxj 7 2 existence existence NN cord-291946-kq0rsuxj 7 3 of of IN cord-291946-kq0rsuxj 7 4 a a DT cord-291946-kq0rsuxj 7 5 paleovirus paleovirus NNP cord-291946-kq0rsuxj 7 6 can can MD cord-291946-kq0rsuxj 7 7 sometimes sometimes RB cord-291946-kq0rsuxj 7 8 be be VB cord-291946-kq0rsuxj 7 9 detected detect VBN cord-291946-kq0rsuxj 7 10 by by IN cord-291946-kq0rsuxj 7 11 virtue virtue NN cord-291946-kq0rsuxj 7 12 of of IN cord-291946-kq0rsuxj 7 13 its -PRON- PRP$ cord-291946-kq0rsuxj 7 14 accidental accidental JJ cord-291946-kq0rsuxj 7 15 insertion insertion NN cord-291946-kq0rsuxj 7 16 into into IN cord-291946-kq0rsuxj 7 17 the the DT cord-291946-kq0rsuxj 7 18 germline germline NN cord-291946-kq0rsuxj 7 19 of of IN cord-291946-kq0rsuxj 7 20 different different JJ cord-291946-kq0rsuxj 7 21 animal animal NN cord-291946-kq0rsuxj 7 22 species specie NNS cord-291946-kq0rsuxj 7 23 , , , cord-291946-kq0rsuxj 7 24 which which WDT cord-291946-kq0rsuxj 7 25 allows allow VBZ cord-291946-kq0rsuxj 7 26 one one CD cord-291946-kq0rsuxj 7 27 to to IN cord-291946-kq0rsuxj 7 28 date date NN cord-291946-kq0rsuxj 7 29 when when WRB cord-291946-kq0rsuxj 7 30 the the DT cord-291946-kq0rsuxj 7 31 virus virus NN cord-291946-kq0rsuxj 7 32 actually actually RB cord-291946-kq0rsuxj 7 33 existed exist VBD cord-291946-kq0rsuxj 7 34 . . . cord-291946-kq0rsuxj 8 1 However however RB cord-291946-kq0rsuxj 8 2 , , , cord-291946-kq0rsuxj 8 3 the the DT cord-291946-kq0rsuxj 8 4 ancient ancient JJ cord-291946-kq0rsuxj 8 5 and and CC cord-291946-kq0rsuxj 8 6 the the DT cord-291946-kq0rsuxj 8 7 modern modern JJ cord-291946-kq0rsuxj 8 8 often often RB cord-291946-kq0rsuxj 8 9 connect connect VBP cord-291946-kq0rsuxj 8 10 , , , cord-291946-kq0rsuxj 8 11 as as IN cord-291946-kq0rsuxj 8 12 modern modern JJ cord-291946-kq0rsuxj 8 13 viruses virus NNS cord-291946-kq0rsuxj 8 14 have have VBP cord-291946-kq0rsuxj 8 15 unexpected unexpected JJ cord-291946-kq0rsuxj 8 16 origins origin NNS cord-291946-kq0rsuxj 8 17 that that WDT cord-291946-kq0rsuxj 8 18 can can MD cord-291946-kq0rsuxj 8 19 be be VB cord-291946-kq0rsuxj 8 20 traced trace VBN cord-291946-kq0rsuxj 8 21 to to IN cord-291946-kq0rsuxj 8 22 ancient ancient JJ cord-291946-kq0rsuxj 8 23 infections infection NNS cord-291946-kq0rsuxj 8 24 . . . cord-291946-kq0rsuxj 9 1 The the DT cord-291946-kq0rsuxj 9 2 genomes genome NNS cord-291946-kq0rsuxj 9 3 of of IN cord-291946-kq0rsuxj 9 4 two two CD cord-291946-kq0rsuxj 9 5 species specie NNS cord-291946-kq0rsuxj 9 6 of of IN cord-291946-kq0rsuxj 9 7 mongooses mongoose NNS cord-291946-kq0rsuxj 9 8 and and CC cord-291946-kq0rsuxj 9 9 an an DT cord-291946-kq0rsuxj 9 10 egg egg NN cord-291946-kq0rsuxj 9 11 - - HYPH cord-291946-kq0rsuxj 9 12 laying lay VBG cord-291946-kq0rsuxj 9 13 mammal mammal NN cord-291946-kq0rsuxj 9 14 called call VBN cord-291946-kq0rsuxj 9 15 an an DT cord-291946-kq0rsuxj 9 16 echidna echidna NN cord-291946-kq0rsuxj 9 17 show show NN cord-291946-kq0rsuxj 9 18 that that IN cord-291946-kq0rsuxj 9 19 a a DT cord-291946-kq0rsuxj 9 20 virus virus NN cord-291946-kq0rsuxj 9 21 currently currently RB cord-291946-kq0rsuxj 9 22 present present JJ cord-291946-kq0rsuxj 9 23 in in IN cord-291946-kq0rsuxj 9 24 poultry poultry NN cord-291946-kq0rsuxj 9 25 , , , cord-291946-kq0rsuxj 9 26 the the DT cord-291946-kq0rsuxj 9 27 reticuloendotheliosis reticuloendotheliosis NNP cord-291946-kq0rsuxj 9 28 virus virus NN cord-291946-kq0rsuxj 9 29 ( ( -LRB- cord-291946-kq0rsuxj 9 30 REV REV NNP cord-291946-kq0rsuxj 9 31 ) ) -RRB- cord-291946-kq0rsuxj 9 32 , , , cord-291946-kq0rsuxj 9 33 is be VBZ cord-291946-kq0rsuxj 9 34 actually actually RB cord-291946-kq0rsuxj 9 35 of of IN cord-291946-kq0rsuxj 9 36 ancient ancient JJ cord-291946-kq0rsuxj 9 37 exotic exotic JJ cord-291946-kq0rsuxj 9 38 mammalian mammalian JJ cord-291946-kq0rsuxj 9 39 origin origin NN cord-291946-kq0rsuxj 9 40 . . . cord-291946-kq0rsuxj 10 1 REV REV NNP cord-291946-kq0rsuxj 10 2 apparently apparently RB cord-291946-kq0rsuxj 10 3 spread spread VBD cord-291946-kq0rsuxj 10 4 to to IN cord-291946-kq0rsuxj 10 5 poultry poultry NN cord-291946-kq0rsuxj 10 6 through through IN cord-291946-kq0rsuxj 10 7 a a DT cord-291946-kq0rsuxj 10 8 circuitous circuitous JJ cord-291946-kq0rsuxj 10 9 route route NN cord-291946-kq0rsuxj 10 10 involving involve VBG cord-291946-kq0rsuxj 10 11 the the DT cord-291946-kq0rsuxj 10 12 isolation isolation NN cord-291946-kq0rsuxj 10 13 of of IN cord-291946-kq0rsuxj 10 14 malaria malaria NN cord-291946-kq0rsuxj 10 15 parasites parasite NNS cord-291946-kq0rsuxj 10 16 from from IN cord-291946-kq0rsuxj 10 17 a a DT cord-291946-kq0rsuxj 10 18 pheasant pheasant NN cord-291946-kq0rsuxj 10 19 from from IN cord-291946-kq0rsuxj 10 20 Borneo Borneo NNP cord-291946-kq0rsuxj 10 21 housed house VBN cord-291946-kq0rsuxj 10 22 at at IN cord-291946-kq0rsuxj 10 23 the the DT cord-291946-kq0rsuxj 10 24 Bronx Bronx NNP cord-291946-kq0rsuxj 10 25 Zoo Zoo NNP cord-291946-kq0rsuxj 10 26 that that WDT cord-291946-kq0rsuxj 10 27 was be VBD cord-291946-kq0rsuxj 10 28 contaminated contaminate VBN cord-291946-kq0rsuxj 10 29 with with IN cord-291946-kq0rsuxj 10 30 REV REV NNP cord-291946-kq0rsuxj 10 31 . . . cord-291946-kq0rsuxj 11 1 Repeated repeat VBN cord-291946-kq0rsuxj 11 2 passage passage NN cord-291946-kq0rsuxj 11 3 of of IN cord-291946-kq0rsuxj 11 4 this this DT cord-291946-kq0rsuxj 11 5 virus virus NN cord-291946-kq0rsuxj 11 6 in in IN cord-291946-kq0rsuxj 11 7 poultry poultry NN cord-291946-kq0rsuxj 11 8 adapted adapt VBD cord-291946-kq0rsuxj 11 9 the the DT cord-291946-kq0rsuxj 11 10 virus virus NN cord-291946-kq0rsuxj 11 11 to to IN cord-291946-kq0rsuxj 11 12 its -PRON- PRP$ cord-291946-kq0rsuxj 11 13 new new JJ cord-291946-kq0rsuxj 11 14 host host NN cord-291946-kq0rsuxj 11 15 . . . cord-291946-kq0rsuxj 12 1 At at IN cord-291946-kq0rsuxj 12 2 some some DT cord-291946-kq0rsuxj 12 3 point point NN cord-291946-kq0rsuxj 12 4 , , , cord-291946-kq0rsuxj 12 5 the the DT cord-291946-kq0rsuxj 12 6 virus virus NN cord-291946-kq0rsuxj 12 7 got get VBD cord-291946-kq0rsuxj 12 8 inserted insert VBN cord-291946-kq0rsuxj 12 9 into into IN cord-291946-kq0rsuxj 12 10 another another DT cord-291946-kq0rsuxj 12 11 virus virus NN cord-291946-kq0rsuxj 12 12 , , , cord-291946-kq0rsuxj 12 13 called call VBN cord-291946-kq0rsuxj 12 14 fowlpox fowlpox NNP cord-291946-kq0rsuxj 12 15 virus virus NN cord-291946-kq0rsuxj 12 16 , , , cord-291946-kq0rsuxj 12 17 which which WDT cord-291946-kq0rsuxj 12 18 has have VBZ cord-291946-kq0rsuxj 12 19 spread spread VBN cord-291946-kq0rsuxj 12 20 back back RB cord-291946-kq0rsuxj 12 21 into into IN cord-291946-kq0rsuxj 12 22 the the DT cord-291946-kq0rsuxj 12 23 wild wild NN cord-291946-kq0rsuxj 12 24 . . . cord-291946-kq0rsuxj 13 1 Although although IN cord-291946-kq0rsuxj 13 2 REV REV NNP cord-291946-kq0rsuxj 13 3 may may MD cord-291946-kq0rsuxj 13 4 still still RB cord-291946-kq0rsuxj 13 5 exist exist VB cord-291946-kq0rsuxj 13 6 somewhere somewhere RB cord-291946-kq0rsuxj 13 7 in in IN cord-291946-kq0rsuxj 13 8 a a DT cord-291946-kq0rsuxj 13 9 mammalian mammalian JJ cord-291946-kq0rsuxj 13 10 host host NN cord-291946-kq0rsuxj 13 11 , , , cord-291946-kq0rsuxj 13 12 its -PRON- PRP$ cord-291946-kq0rsuxj 13 13 modern modern JJ cord-291946-kq0rsuxj 13 14 form form NN cord-291946-kq0rsuxj 13 15 links link VBZ cord-291946-kq0rsuxj 13 16 an an DT cord-291946-kq0rsuxj 13 17 8 8 CD cord-291946-kq0rsuxj 13 18 million million CD cord-291946-kq0rsuxj 13 19 - - HYPH cord-291946-kq0rsuxj 13 20 year year NN cord-291946-kq0rsuxj 13 21 - - HYPH cord-291946-kq0rsuxj 13 22 old old JJ cord-291946-kq0rsuxj 13 23 infection infection NN cord-291946-kq0rsuxj 13 24 of of IN cord-291946-kq0rsuxj 13 25 the the DT cord-291946-kq0rsuxj 13 26 ancestor ancestor NN cord-291946-kq0rsuxj 13 27 of of IN cord-291946-kq0rsuxj 13 28 a a DT cord-291946-kq0rsuxj 13 29 mongoose mongoose NN cord-291946-kq0rsuxj 13 30 to to IN cord-291946-kq0rsuxj 13 31 a a DT cord-291946-kq0rsuxj 13 32 virus virus NN cord-291946-kq0rsuxj 13 33 that that WDT cord-291946-kq0rsuxj 13 34 now now RB cord-291946-kq0rsuxj 13 35 is be VBZ cord-291946-kq0rsuxj 13 36 circulating circulate VBG cord-291946-kq0rsuxj 13 37 in in IN cord-291946-kq0rsuxj 13 38 wild wild JJ cord-291946-kq0rsuxj 13 39 birds bird NNS cord-291946-kq0rsuxj 13 40 through through IN cord-291946-kq0rsuxj 13 41 malaria malaria NN cord-291946-kq0rsuxj 13 42 studies study NNS cord-291946-kq0rsuxj 13 43 in in IN cord-291946-kq0rsuxj 13 44 the the DT cord-291946-kq0rsuxj 13 45 mid-20(th mid-20(th NNP cord-291946-kq0rsuxj 13 46 ) ) -RRB- cord-291946-kq0rsuxj 13 47 century century NN cord-291946-kq0rsuxj 13 48 . . . cord-291946-kq0rsuxj 14 1 These these DT cord-291946-kq0rsuxj 14 2 lessons lesson NNS cord-291946-kq0rsuxj 14 3 of of IN cord-291946-kq0rsuxj 14 4 ancient ancient JJ cord-291946-kq0rsuxj 14 5 and and CC cord-291946-kq0rsuxj 14 6 modern modern JJ cord-291946-kq0rsuxj 14 7 viruses virus NNS cord-291946-kq0rsuxj 14 8 have have VBP cord-291946-kq0rsuxj 14 9 implications implication NNS cord-291946-kq0rsuxj 14 10 for for IN cord-291946-kq0rsuxj 14 11 modern modern JJ cord-291946-kq0rsuxj 14 12 human human JJ cord-291946-kq0rsuxj 14 13 pandemics pandemic NNS cord-291946-kq0rsuxj 14 14 from from IN cord-291946-kq0rsuxj 14 15 viral viral JJ cord-291946-kq0rsuxj 14 16 reservoirs reservoir NNS cord-291946-kq0rsuxj 14 17 and and CC cord-291946-kq0rsuxj 14 18 for for IN cord-291946-kq0rsuxj 14 19 human human JJ cord-291946-kq0rsuxj 14 20 interventions intervention NNS cord-291946-kq0rsuxj 14 21 that that WDT cord-291946-kq0rsuxj 14 22 may may MD cord-291946-kq0rsuxj 14 23 come come VB cord-291946-kq0rsuxj 14 24 with with IN cord-291946-kq0rsuxj 14 25 unintended unintended JJ cord-291946-kq0rsuxj 14 26 consequences consequence NNS cord-291946-kq0rsuxj 14 27 . . . cord-291946-kq0rsuxj 15 1 The the DT cord-291946-kq0rsuxj 15 2 existence existence NN cord-291946-kq0rsuxj 15 3 of of IN cord-291946-kq0rsuxj 15 4 a a DT cord-291946-kq0rsuxj 15 5 paleovirus paleovirus NNP cord-291946-kq0rsuxj 15 6 can can MD cord-291946-kq0rsuxj 15 7 sometimes sometimes RB cord-291946-kq0rsuxj 15 8 be be VB cord-291946-kq0rsuxj 15 9 detected detect VBN cord-291946-kq0rsuxj 15 10 by by IN cord-291946-kq0rsuxj 15 11 virtue virtue NN cord-291946-kq0rsuxj 15 12 of of IN cord-291946-kq0rsuxj 15 13 its -PRON- PRP$ cord-291946-kq0rsuxj 15 14 accidental accidental JJ cord-291946-kq0rsuxj 15 15 insertion insertion NN cord-291946-kq0rsuxj 15 16 into into IN cord-291946-kq0rsuxj 15 17 the the DT cord-291946-kq0rsuxj 15 18 germline germline NN cord-291946-kq0rsuxj 15 19 of of IN cord-291946-kq0rsuxj 15 20 different different JJ cord-291946-kq0rsuxj 15 21 animal animal NN cord-291946-kq0rsuxj 15 22 species specie NNS cord-291946-kq0rsuxj 15 23 , , , cord-291946-kq0rsuxj 15 24 which which WDT cord-291946-kq0rsuxj 15 25 allows allow VBZ cord-291946-kq0rsuxj 15 26 one one CD cord-291946-kq0rsuxj 15 27 to to IN cord-291946-kq0rsuxj 15 28 date date NN cord-291946-kq0rsuxj 15 29 when when WRB cord-291946-kq0rsuxj 15 30 the the DT cord-291946-kq0rsuxj 15 31 virus virus NN cord-291946-kq0rsuxj 15 32 actually actually RB cord-291946-kq0rsuxj 15 33 existed exist VBD cord-291946-kq0rsuxj 15 34 . . . cord-291946-kq0rsuxj 16 1 However however RB cord-291946-kq0rsuxj 16 2 , , , cord-291946-kq0rsuxj 16 3 the the DT cord-291946-kq0rsuxj 16 4 ancient ancient JJ cord-291946-kq0rsuxj 16 5 and and CC cord-291946-kq0rsuxj 16 6 the the DT cord-291946-kq0rsuxj 16 7 modern modern JJ cord-291946-kq0rsuxj 16 8 often often RB cord-291946-kq0rsuxj 16 9 connect connect VBP cord-291946-kq0rsuxj 16 10 , , , cord-291946-kq0rsuxj 16 11 as as IN cord-291946-kq0rsuxj 16 12 modern modern JJ cord-291946-kq0rsuxj 16 13 viruses virus NNS cord-291946-kq0rsuxj 16 14 have have VBP cord-291946-kq0rsuxj 16 15 unexpected unexpected JJ cord-291946-kq0rsuxj 16 16 origins origin NNS cord-291946-kq0rsuxj 16 17 that that WDT cord-291946-kq0rsuxj 16 18 can can MD cord-291946-kq0rsuxj 16 19 be be VB cord-291946-kq0rsuxj 16 20 traced trace VBN cord-291946-kq0rsuxj 16 21 to to IN cord-291946-kq0rsuxj 16 22 ancient ancient JJ cord-291946-kq0rsuxj 16 23 infections infection NNS cord-291946-kq0rsuxj 16 24 . . . cord-291946-kq0rsuxj 17 1 The the DT cord-291946-kq0rsuxj 17 2 genomes genome NNS cord-291946-kq0rsuxj 17 3 of of IN cord-291946-kq0rsuxj 17 4 two two CD cord-291946-kq0rsuxj 17 5 species specie NNS cord-291946-kq0rsuxj 17 6 of of IN cord-291946-kq0rsuxj 17 7 mongooses mongoose NNS cord-291946-kq0rsuxj 17 8 and and CC cord-291946-kq0rsuxj 17 9 an an DT cord-291946-kq0rsuxj 17 10 egg egg NN cord-291946-kq0rsuxj 17 11 - - HYPH cord-291946-kq0rsuxj 17 12 laying lay VBG cord-291946-kq0rsuxj 17 13 mammal mammal NN cord-291946-kq0rsuxj 17 14 called call VBN cord-291946-kq0rsuxj 17 15 an an DT cord-291946-kq0rsuxj 17 16 echidna echidna NN cord-291946-kq0rsuxj 17 17 show show NN cord-291946-kq0rsuxj 17 18 that that IN cord-291946-kq0rsuxj 17 19 a a DT cord-291946-kq0rsuxj 17 20 virus virus NN cord-291946-kq0rsuxj 17 21 currently currently RB cord-291946-kq0rsuxj 17 22 present present JJ cord-291946-kq0rsuxj 17 23 in in IN cord-291946-kq0rsuxj 17 24 poultry poultry NN cord-291946-kq0rsuxj 17 25 , , , cord-291946-kq0rsuxj 17 26 the the DT cord-291946-kq0rsuxj 17 27 reticuloendotheliosis reticuloendotheliosis NNP cord-291946-kq0rsuxj 17 28 virus virus NN cord-291946-kq0rsuxj 17 29 ( ( -LRB- cord-291946-kq0rsuxj 17 30 REV REV NNP cord-291946-kq0rsuxj 17 31 ) ) -RRB- cord-291946-kq0rsuxj 17 32 , , , cord-291946-kq0rsuxj 17 33 is be VBZ cord-291946-kq0rsuxj 17 34 actually actually RB cord-291946-kq0rsuxj 17 35 of of IN cord-291946-kq0rsuxj 17 36 ancient ancient JJ cord-291946-kq0rsuxj 17 37 exotic exotic JJ cord-291946-kq0rsuxj 17 38 mammalian mammalian JJ cord-291946-kq0rsuxj 17 39 origin origin NN cord-291946-kq0rsuxj 17 40 . . . cord-291946-kq0rsuxj 18 1 REV REV NNP cord-291946-kq0rsuxj 18 2 apparently apparently RB cord-291946-kq0rsuxj 18 3 spread spread VBD cord-291946-kq0rsuxj 18 4 to to IN cord-291946-kq0rsuxj 18 5 poultry poultry NN cord-291946-kq0rsuxj 18 6 through through IN cord-291946-kq0rsuxj 18 7 a a DT cord-291946-kq0rsuxj 18 8 circuitous circuitous JJ cord-291946-kq0rsuxj 18 9 route route NN cord-291946-kq0rsuxj 18 10 involving involve VBG cord-291946-kq0rsuxj 18 11 the the DT cord-291946-kq0rsuxj 18 12 isolation isolation NN cord-291946-kq0rsuxj 18 13 of of IN cord-291946-kq0rsuxj 18 14 malaria malaria NN cord-291946-kq0rsuxj 18 15 parasites parasite NNS cord-291946-kq0rsuxj 18 16 from from IN cord-291946-kq0rsuxj 18 17 a a DT cord-291946-kq0rsuxj 18 18 pheasant pheasant NN cord-291946-kq0rsuxj 18 19 from from IN cord-291946-kq0rsuxj 18 20 Borneo Borneo NNP cord-291946-kq0rsuxj 18 21 housed house VBN cord-291946-kq0rsuxj 18 22 at at IN cord-291946-kq0rsuxj 18 23 the the DT cord-291946-kq0rsuxj 18 24 Bronx Bronx NNP cord-291946-kq0rsuxj 18 25 Zoo Zoo NNP cord-291946-kq0rsuxj 18 26 that that WDT cord-291946-kq0rsuxj 18 27 was be VBD cord-291946-kq0rsuxj 18 28 contaminated contaminate VBN cord-291946-kq0rsuxj 18 29 with with IN cord-291946-kq0rsuxj 18 30 REV REV NNP cord-291946-kq0rsuxj 18 31 . . . cord-291946-kq0rsuxj 19 1 Repeated repeat VBN cord-291946-kq0rsuxj 19 2 passage passage NN cord-291946-kq0rsuxj 19 3 of of IN cord-291946-kq0rsuxj 19 4 this this DT cord-291946-kq0rsuxj 19 5 virus virus NN cord-291946-kq0rsuxj 19 6 in in IN cord-291946-kq0rsuxj 19 7 poultry poultry NN cord-291946-kq0rsuxj 19 8 adapted adapt VBD cord-291946-kq0rsuxj 19 9 the the DT cord-291946-kq0rsuxj 19 10 virus virus NN cord-291946-kq0rsuxj 19 11 to to IN cord-291946-kq0rsuxj 19 12 its -PRON- PRP$ cord-291946-kq0rsuxj 19 13 new new JJ cord-291946-kq0rsuxj 19 14 host host NN cord-291946-kq0rsuxj 19 15 . . . cord-291946-kq0rsuxj 20 1 At at IN cord-291946-kq0rsuxj 20 2 some some DT cord-291946-kq0rsuxj 20 3 point point NN cord-291946-kq0rsuxj 20 4 , , , cord-291946-kq0rsuxj 20 5 the the DT cord-291946-kq0rsuxj 20 6 virus virus NN cord-291946-kq0rsuxj 20 7 got get VBD cord-291946-kq0rsuxj 20 8 inserted insert VBN cord-291946-kq0rsuxj 20 9 into into IN cord-291946-kq0rsuxj 20 10 another another DT cord-291946-kq0rsuxj 20 11 virus virus NN cord-291946-kq0rsuxj 20 12 , , , cord-291946-kq0rsuxj 20 13 called call VBN cord-291946-kq0rsuxj 20 14 fowlpox fowlpox NNP cord-291946-kq0rsuxj 20 15 virus virus NN cord-291946-kq0rsuxj 20 16 , , , cord-291946-kq0rsuxj 20 17 which which WDT cord-291946-kq0rsuxj 20 18 has have VBZ cord-291946-kq0rsuxj 20 19 spread spread VBN cord-291946-kq0rsuxj 20 20 back back RB cord-291946-kq0rsuxj 20 21 into into IN cord-291946-kq0rsuxj 20 22 the the DT cord-291946-kq0rsuxj 20 23 wild wild NN cord-291946-kq0rsuxj 20 24 . . . cord-291946-kq0rsuxj 21 1 Although although IN cord-291946-kq0rsuxj 21 2 REV REV NNP cord-291946-kq0rsuxj 21 3 may may MD cord-291946-kq0rsuxj 21 4 still still RB cord-291946-kq0rsuxj 21 5 exist exist VB cord-291946-kq0rsuxj 21 6 somewhere somewhere RB cord-291946-kq0rsuxj 21 7 in in IN cord-291946-kq0rsuxj 21 8 a a DT cord-291946-kq0rsuxj 21 9 mammalian mammalian JJ cord-291946-kq0rsuxj 21 10 host host NN cord-291946-kq0rsuxj 21 11 , , , cord-291946-kq0rsuxj 21 12 its -PRON- PRP$ cord-291946-kq0rsuxj 21 13 modern modern JJ cord-291946-kq0rsuxj 21 14 form form NN cord-291946-kq0rsuxj 21 15 links link VBZ cord-291946-kq0rsuxj 21 16 an an DT cord-291946-kq0rsuxj 21 17 8 8 CD cord-291946-kq0rsuxj 21 18 million million CD cord-291946-kq0rsuxj 21 19 - - HYPH cord-291946-kq0rsuxj 21 20 year year NN cord-291946-kq0rsuxj 21 21 - - HYPH cord-291946-kq0rsuxj 21 22 old old JJ cord-291946-kq0rsuxj 21 23 infection infection NN cord-291946-kq0rsuxj 21 24 of of IN cord-291946-kq0rsuxj 21 25 the the DT cord-291946-kq0rsuxj 21 26 ancestor ancestor NN cord-291946-kq0rsuxj 21 27 of of IN cord-291946-kq0rsuxj 21 28 a a DT cord-291946-kq0rsuxj 21 29 mongoose mongoose NN cord-291946-kq0rsuxj 21 30 to to IN cord-291946-kq0rsuxj 21 31 a a DT cord-291946-kq0rsuxj 21 32 virus virus NN cord-291946-kq0rsuxj 21 33 that that WDT cord-291946-kq0rsuxj 21 34 now now RB cord-291946-kq0rsuxj 21 35 is be VBZ cord-291946-kq0rsuxj 21 36 circulating circulate VBG cord-291946-kq0rsuxj 21 37 in in IN cord-291946-kq0rsuxj 21 38 wild wild JJ cord-291946-kq0rsuxj 21 39 birds bird NNS cord-291946-kq0rsuxj 21 40 through through IN cord-291946-kq0rsuxj 21 41 malaria malaria NN cord-291946-kq0rsuxj 21 42 studies study NNS cord-291946-kq0rsuxj 21 43 in in IN cord-291946-kq0rsuxj 21 44 the the DT cord-291946-kq0rsuxj 21 45 mid-20 mid-20 NN cord-291946-kq0rsuxj 21 46 th th XX cord-291946-kq0rsuxj 21 47 century century NN cord-291946-kq0rsuxj 21 48 . . . cord-291946-kq0rsuxj 22 1 These these DT cord-291946-kq0rsuxj 22 2 lessons lesson NNS cord-291946-kq0rsuxj 22 3 of of IN cord-291946-kq0rsuxj 22 4 ancient ancient JJ cord-291946-kq0rsuxj 22 5 and and CC cord-291946-kq0rsuxj 22 6 modern modern JJ cord-291946-kq0rsuxj 22 7 viruses virus NNS cord-291946-kq0rsuxj 22 8 have have VBP cord-291946-kq0rsuxj 22 9 implications implication NNS cord-291946-kq0rsuxj 22 10 for for IN cord-291946-kq0rsuxj 22 11 modern modern JJ cord-291946-kq0rsuxj 22 12 human human JJ cord-291946-kq0rsuxj 22 13 pandemics pandemic NNS cord-291946-kq0rsuxj 22 14 from from IN cord-291946-kq0rsuxj 22 15 viral viral JJ cord-291946-kq0rsuxj 22 16 reservoirs reservoir NNS cord-291946-kq0rsuxj 22 17 and and CC cord-291946-kq0rsuxj 22 18 for for IN cord-291946-kq0rsuxj 22 19 human human JJ cord-291946-kq0rsuxj 22 20 interventions intervention NNS cord-291946-kq0rsuxj 22 21 that that WDT cord-291946-kq0rsuxj 22 22 may may MD cord-291946-kq0rsuxj 22 23 come come VB cord-291946-kq0rsuxj 22 24 with with IN cord-291946-kq0rsuxj 22 25 unintended unintended JJ cord-291946-kq0rsuxj 22 26 consequences consequence NNS cord-291946-kq0rsuxj 22 27 . . . cord-291946-kq0rsuxj 23 1 Outbreaks outbreak NNS cord-291946-kq0rsuxj 23 2 of of IN cord-291946-kq0rsuxj 23 3 ' ' '' cord-291946-kq0rsuxj 23 4 ' ' `` cord-291946-kq0rsuxj 23 5 new new JJ cord-291946-kq0rsuxj 23 6 ' ' '' cord-291946-kq0rsuxj 23 7 ' ' '' cord-291946-kq0rsuxj 23 8 viruses virus NNS cord-291946-kq0rsuxj 23 9 are be VBP cord-291946-kq0rsuxj 23 10 real real JJ cord-291946-kq0rsuxj 23 11 causes cause NNS cord-291946-kq0rsuxj 23 12 of of IN cord-291946-kq0rsuxj 23 13 concern concern NN cord-291946-kq0rsuxj 23 14 for for IN cord-291946-kq0rsuxj 23 15 human human JJ cord-291946-kq0rsuxj 23 16 and and CC cord-291946-kq0rsuxj 23 17 animal animal NN cord-291946-kq0rsuxj 23 18 health health NN cord-291946-kq0rsuxj 23 19 . . . cord-291946-kq0rsuxj 24 1 But but CC cord-291946-kq0rsuxj 24 2 where where WRB cord-291946-kq0rsuxj 24 3 do do VBP cord-291946-kq0rsuxj 24 4 they -PRON- PRP cord-291946-kq0rsuxj 24 5 come come VB cord-291946-kq0rsuxj 24 6 from from IN cord-291946-kq0rsuxj 24 7 ? ? . cord-291946-kq0rsuxj 25 1 The the DT cord-291946-kq0rsuxj 25 2 vast vast JJ cord-291946-kq0rsuxj 25 3 majority majority NN cord-291946-kq0rsuxj 25 4 of of IN cord-291946-kq0rsuxj 25 5 emerging emerge VBG cord-291946-kq0rsuxj 25 6 viruses virus NNS cord-291946-kq0rsuxj 25 7 in in IN cord-291946-kq0rsuxj 25 8 the the DT cord-291946-kq0rsuxj 25 9 human human JJ cord-291946-kq0rsuxj 25 10 population population NN cord-291946-kq0rsuxj 25 11 originate originate VBP cord-291946-kq0rsuxj 25 12 from from IN cord-291946-kq0rsuxj 25 13 other other JJ cord-291946-kq0rsuxj 25 14 animals animal NNS cord-291946-kq0rsuxj 25 15 [ [ -LRB- cord-291946-kq0rsuxj 25 16 1 1 CD cord-291946-kq0rsuxj 25 17 ] ] -RRB- cord-291946-kq0rsuxj 25 18 . . . cord-291946-kq0rsuxj 26 1 In in IN cord-291946-kq0rsuxj 26 2 fact fact NN cord-291946-kq0rsuxj 26 3 , , , cord-291946-kq0rsuxj 26 4 when when WRB cord-291946-kq0rsuxj 26 5 a a DT cord-291946-kq0rsuxj 26 6 new new JJ cord-291946-kq0rsuxj 26 7 virus virus NN cord-291946-kq0rsuxj 26 8 appears appear VBZ cord-291946-kq0rsuxj 26 9 , , , cord-291946-kq0rsuxj 26 10 it -PRON- PRP cord-291946-kq0rsuxj 26 11 is be VBZ cord-291946-kq0rsuxj 26 12 often often RB cord-291946-kq0rsuxj 26 13 a a DT cord-291946-kq0rsuxj 26 14 virus virus NN cord-291946-kq0rsuxj 26 15 that that WDT cord-291946-kq0rsuxj 26 16 already already RB cord-291946-kq0rsuxj 26 17 exists exist VBZ cord-291946-kq0rsuxj 26 18 in in IN cord-291946-kq0rsuxj 26 19 one one CD cord-291946-kq0rsuxj 26 20 species specie NNS cord-291946-kq0rsuxj 26 21 , , , cord-291946-kq0rsuxj 26 22 but but CC cord-291946-kq0rsuxj 26 23 then then RB cord-291946-kq0rsuxj 26 24 becomes become VBZ cord-291946-kq0rsuxj 26 25 established establish VBN cord-291946-kq0rsuxj 26 26 in in IN cord-291946-kq0rsuxj 26 27 another another DT cord-291946-kq0rsuxj 26 28 . . . cord-291946-kq0rsuxj 27 1 For for IN cord-291946-kq0rsuxj 27 2 example example NN cord-291946-kq0rsuxj 27 3 , , , cord-291946-kq0rsuxj 27 4 the the DT cord-291946-kq0rsuxj 27 5 transmission transmission NN cord-291946-kq0rsuxj 27 6 of of IN cord-291946-kq0rsuxj 27 7 a a DT cord-291946-kq0rsuxj 27 8 coronavirus coronavirus NN cord-291946-kq0rsuxj 27 9 ( ( -LRB- cord-291946-kq0rsuxj 27 10 CoV cov NN cord-291946-kq0rsuxj 27 11 ) ) -RRB- cord-291946-kq0rsuxj 27 12 from from IN cord-291946-kq0rsuxj 27 13 bats bat NNS cord-291946-kq0rsuxj 27 14 to to IN cord-291946-kq0rsuxj 27 15 palm palm NN cord-291946-kq0rsuxj 27 16 civets civet NNS cord-291946-kq0rsuxj 27 17 and and CC cord-291946-kq0rsuxj 27 18 raccoon raccoon NN cord-291946-kq0rsuxj 27 19 dogs dog NNS cord-291946-kq0rsuxj 27 20 and and CC cord-291946-kq0rsuxj 27 21 ultimately ultimately RB cord-291946-kq0rsuxj 27 22 to to IN cord-291946-kq0rsuxj 27 23 humans human NNS cord-291946-kq0rsuxj 27 24 led lead VBD cord-291946-kq0rsuxj 27 25 to to IN cord-291946-kq0rsuxj 27 26 the the DT cord-291946-kq0rsuxj 27 27 emergence emergence NN cord-291946-kq0rsuxj 27 28 of of IN cord-291946-kq0rsuxj 27 29 severe severe JJ cord-291946-kq0rsuxj 27 30 acute acute JJ cord-291946-kq0rsuxj 27 31 respiratory respiratory JJ cord-291946-kq0rsuxj 27 32 syndrome syndrome NN cord-291946-kq0rsuxj 27 33 ( ( -LRB- cord-291946-kq0rsuxj 27 34 SARS SARS NNP cord-291946-kq0rsuxj 27 35 - - HYPH cord-291946-kq0rsuxj 27 36 CoV CoV NNP cord-291946-kq0rsuxj 27 37 ) ) -RRB- cord-291946-kq0rsuxj 27 38 , , , cord-291946-kq0rsuxj 27 39 which which WDT cord-291946-kq0rsuxj 27 40 created create VBD cord-291946-kq0rsuxj 27 41 an an DT cord-291946-kq0rsuxj 27 42 epidemic epidemic NN cord-291946-kq0rsuxj 27 43 in in IN cord-291946-kq0rsuxj 27 44 2003 2003 CD cord-291946-kq0rsuxj 27 45 , , , cord-291946-kq0rsuxj 27 46 with with IN cord-291946-kq0rsuxj 27 47 8,000 8,000 CD cord-291946-kq0rsuxj 27 48 people people NNS cord-291946-kq0rsuxj 27 49 infected infect VBN cord-291946-kq0rsuxj 27 50 and and CC cord-291946-kq0rsuxj 27 51 700 700 CD cord-291946-kq0rsuxj 27 52 deaths death NNS cord-291946-kq0rsuxj 27 53 before before IN cord-291946-kq0rsuxj 27 54 it -PRON- PRP cord-291946-kq0rsuxj 27 55 was be VBD cord-291946-kq0rsuxj 27 56 finally finally RB cord-291946-kq0rsuxj 27 57 eliminated eliminate VBN cord-291946-kq0rsuxj 27 58 in in IN cord-291946-kq0rsuxj 27 59 humans human NNS cord-291946-kq0rsuxj 27 60 [ [ -LRB- cord-291946-kq0rsuxj 27 61 2 2 CD cord-291946-kq0rsuxj 27 62 ] ] -RRB- cord-291946-kq0rsuxj 27 63 . . . cord-291946-kq0rsuxj 28 1 Another another DT cord-291946-kq0rsuxj 28 2 example example NN cord-291946-kq0rsuxj 28 3 is be VBZ cord-291946-kq0rsuxj 28 4 the the DT cord-291946-kq0rsuxj 28 5 transmission transmission NN cord-291946-kq0rsuxj 28 6 of of IN cord-291946-kq0rsuxj 28 7 influenza influenza NN cord-291946-kq0rsuxj 28 8 virus virus NN cord-291946-kq0rsuxj 28 9 from from IN cord-291946-kq0rsuxj 28 10 birds bird NNS cord-291946-kq0rsuxj 28 11 to to IN cord-291946-kq0rsuxj 28 12 mammals mammal NNS cord-291946-kq0rsuxj 28 13 ( ( -LRB- cord-291946-kq0rsuxj 28 14 pigs pig NNS cord-291946-kq0rsuxj 28 15 and and CC cord-291946-kq0rsuxj 28 16 humans human NNS cord-291946-kq0rsuxj 28 17 ) ) -RRB- cord-291946-kq0rsuxj 28 18 in in IN cord-291946-kq0rsuxj 28 19 1918 1918 CD cord-291946-kq0rsuxj 28 20 that that WDT cord-291946-kq0rsuxj 28 21 was be VBD cord-291946-kq0rsuxj 28 22 responsible responsible JJ cord-291946-kq0rsuxj 28 23 for for IN cord-291946-kq0rsuxj 28 24 over over IN cord-291946-kq0rsuxj 28 25 100 100 CD cord-291946-kq0rsuxj 28 26 million million CD cord-291946-kq0rsuxj 28 27 deaths death NNS cord-291946-kq0rsuxj 28 28 worldwide worldwide RB cord-291946-kq0rsuxj 28 29 [ [ -LRB- cord-291946-kq0rsuxj 28 30 3 3 CD cord-291946-kq0rsuxj 28 31 ] ] -RRB- cord-291946-kq0rsuxj 28 32 , , , cord-291946-kq0rsuxj 28 33 and and CC cord-291946-kq0rsuxj 28 34 many many JJ cord-291946-kq0rsuxj 28 35 of of IN cord-291946-kq0rsuxj 28 36 the the DT cord-291946-kq0rsuxj 28 37 genes gene NNS cord-291946-kq0rsuxj 28 38 from from IN cord-291946-kq0rsuxj 28 39 this this DT cord-291946-kq0rsuxj 28 40 virus virus NN cord-291946-kq0rsuxj 28 41 continue continue VBP cord-291946-kq0rsuxj 28 42 to to TO cord-291946-kq0rsuxj 28 43 circulate circulate VB cord-291946-kq0rsuxj 28 44 in in IN cord-291946-kq0rsuxj 28 45 human human JJ cord-291946-kq0rsuxj 28 46 influenza influenza NN cord-291946-kq0rsuxj 28 47 to to IN cord-291946-kq0rsuxj 28 48 this this DT cord-291946-kq0rsuxj 28 49 day day NN cord-291946-kq0rsuxj 28 50 . . . cord-291946-kq0rsuxj 29 1 Whether whether IN cord-291946-kq0rsuxj 29 2 or or CC cord-291946-kq0rsuxj 29 3 not not RB cord-291946-kq0rsuxj 29 4 a a DT cord-291946-kq0rsuxj 29 5 virus virus NN cord-291946-kq0rsuxj 29 6 will will MD cord-291946-kq0rsuxj 29 7 ' ' '' cord-291946-kq0rsuxj 29 8 ' ' '' cord-291946-kq0rsuxj 29 9 emerge emerge VB cord-291946-kq0rsuxj 29 10 ' ' '' cord-291946-kq0rsuxj 29 11 ' ' '' cord-291946-kq0rsuxj 30 1 in in IN cord-291946-kq0rsuxj 30 2 new new JJ cord-291946-kq0rsuxj 30 3 species specie NNS cord-291946-kq0rsuxj 30 4 depends depend VBZ cord-291946-kq0rsuxj 30 5 on on IN cord-291946-kq0rsuxj 30 6 a a DT cord-291946-kq0rsuxj 30 7 complex complex JJ cord-291946-kq0rsuxj 30 8 set set NN cord-291946-kq0rsuxj 30 9 of of IN cord-291946-kq0rsuxj 30 10 requirements requirement NNS cord-291946-kq0rsuxj 30 11 including include VBG cord-291946-kq0rsuxj 30 12 contact contact NN cord-291946-kq0rsuxj 30 13 , , , cord-291946-kq0rsuxj 30 14 mode mode NN cord-291946-kq0rsuxj 30 15 of of IN cord-291946-kq0rsuxj 30 16 transmission transmission NN cord-291946-kq0rsuxj 30 17 , , , cord-291946-kq0rsuxj 30 18 and and CC cord-291946-kq0rsuxj 30 19 adaptation adaptation NN cord-291946-kq0rsuxj 30 20 to to IN cord-291946-kq0rsuxj 30 21 the the DT cord-291946-kq0rsuxj 30 22 new new JJ cord-291946-kq0rsuxj 30 23 species specie NNS cord-291946-kq0rsuxj 30 24 [ [ -LRB- cord-291946-kq0rsuxj 30 25 4 4 CD cord-291946-kq0rsuxj 30 26 , , , cord-291946-kq0rsuxj 30 27 5 5 CD cord-291946-kq0rsuxj 30 28 ] ] -RRB- cord-291946-kq0rsuxj 30 29 . . . cord-291946-kq0rsuxj 31 1 Moreover moreover RB cord-291946-kq0rsuxj 31 2 , , , cord-291946-kq0rsuxj 31 3 human human JJ cord-291946-kq0rsuxj 31 4 interventions intervention NNS cord-291946-kq0rsuxj 31 5 can can MD cord-291946-kq0rsuxj 31 6 sometimes sometimes RB cord-291946-kq0rsuxj 31 7 accidentally accidentally RB cord-291946-kq0rsuxj 31 8 facilitate facilitate VB cord-291946-kq0rsuxj 31 9 the the DT cord-291946-kq0rsuxj 31 10 transfer transfer NN cord-291946-kq0rsuxj 31 11 of of IN cord-291946-kq0rsuxj 31 12 infectious infectious JJ cord-291946-kq0rsuxj 31 13 agents agent NNS cord-291946-kq0rsuxj 31 14 to to IN cord-291946-kq0rsuxj 31 15 an an DT cord-291946-kq0rsuxj 31 16 animal animal NN cord-291946-kq0rsuxj 31 17 species species NN cord-291946-kq0rsuxj 31 18 where where WRB cord-291946-kq0rsuxj 31 19 they -PRON- PRP cord-291946-kq0rsuxj 31 20 did do VBD cord-291946-kq0rsuxj 31 21 not not RB cord-291946-kq0rsuxj 31 22 previously previously RB cord-291946-kq0rsuxj 31 23 exist exist VB cord-291946-kq0rsuxj 31 24 . . . cord-291946-kq0rsuxj 32 1 For for IN cord-291946-kq0rsuxj 32 2 example example NN cord-291946-kq0rsuxj 32 3 , , , cord-291946-kq0rsuxj 32 4 the the DT cord-291946-kq0rsuxj 32 5 spread spread NN cord-291946-kq0rsuxj 32 6 of of IN cord-291946-kq0rsuxj 32 7 ' ' '' cord-291946-kq0rsuxj 32 8 ' ' `` cord-291946-kq0rsuxj 32 9 mad mad JJ cord-291946-kq0rsuxj 32 10 cow cow NN cord-291946-kq0rsuxj 32 11 ' ' '' cord-291946-kq0rsuxj 32 12 ' ' '' cord-291946-kq0rsuxj 32 13 disease disease NN cord-291946-kq0rsuxj 32 14 from from IN cord-291946-kq0rsuxj 32 15 sheep sheep NNS cord-291946-kq0rsuxj 32 16 to to IN cord-291946-kq0rsuxj 32 17 cattle cattle NNS cord-291946-kq0rsuxj 32 18 ( ( -LRB- cord-291946-kq0rsuxj 32 19 and and CC cord-291946-kq0rsuxj 32 20 then then RB cord-291946-kq0rsuxj 32 21 subsequently subsequently RB cord-291946-kq0rsuxj 32 22 to to IN cord-291946-kq0rsuxj 32 23 humans human NNS cord-291946-kq0rsuxj 32 24 ) ) -RRB- cord-291946-kq0rsuxj 32 25 in in IN cord-291946-kq0rsuxj 32 26 the the DT cord-291946-kq0rsuxj 32 27 1980s 1980 NNS cord-291946-kq0rsuxj 32 28 occurred occur VBD cord-291946-kq0rsuxj 32 29 through through IN cord-291946-kq0rsuxj 32 30 changes change NNS cord-291946-kq0rsuxj 32 31 in in IN cord-291946-kq0rsuxj 32 32 how how WRB cord-291946-kq0rsuxj 32 33 cattle cattle NNS cord-291946-kq0rsuxj 32 34 feed feed NN cord-291946-kq0rsuxj 32 35 was be VBD cord-291946-kq0rsuxj 32 36 prepared prepare VBN cord-291946-kq0rsuxj 32 37 [ [ -LRB- cord-291946-kq0rsuxj 32 38 6 6 CD cord-291946-kq0rsuxj 32 39 ] ] -RRB- cord-291946-kq0rsuxj 32 40 . . . cord-291946-kq0rsuxj 33 1 In in IN cord-291946-kq0rsuxj 33 2 about about RB cord-291946-kq0rsuxj 33 3 the the DT cord-291946-kq0rsuxj 33 4 same same JJ cord-291946-kq0rsuxj 33 5 time time NN cord-291946-kq0rsuxj 33 6 - - HYPH cord-291946-kq0rsuxj 33 7 period period NN cord-291946-kq0rsuxj 33 8 , , , cord-291946-kq0rsuxj 33 9 the the DT cord-291946-kq0rsuxj 33 10 spread spread NN cord-291946-kq0rsuxj 33 11 of of IN cord-291946-kq0rsuxj 33 12 a a DT cord-291946-kq0rsuxj 33 13 relative relative NN cord-291946-kq0rsuxj 33 14 of of IN cord-291946-kq0rsuxj 33 15 HIV HIV NNP cord-291946-kq0rsuxj 33 16 , , , cord-291946-kq0rsuxj 33 17 the the DT cord-291946-kq0rsuxj 33 18 simian simian JJ cord-291946-kq0rsuxj 33 19 immunodeficiency immunodeficiency NN cord-291946-kq0rsuxj 33 20 virus virus NN cord-291946-kq0rsuxj 33 21 ( ( -LRB- cord-291946-kq0rsuxj 33 22 SIV SIV NNP cord-291946-kq0rsuxj 33 23 ) ) -RRB- cord-291946-kq0rsuxj 33 24 , , , cord-291946-kq0rsuxj 33 25 from from IN cord-291946-kq0rsuxj 33 26 an an DT cord-291946-kq0rsuxj 33 27 African african JJ cord-291946-kq0rsuxj 33 28 monkey monkey NN cord-291946-kq0rsuxj 33 29 species specie NNS cord-291946-kq0rsuxj 33 30 to to IN cord-291946-kq0rsuxj 33 31 a a DT cord-291946-kq0rsuxj 33 32 previously previously RB cord-291946-kq0rsuxj 33 33 uninfected uninfected JJ cord-291946-kq0rsuxj 33 34 Asian asian JJ cord-291946-kq0rsuxj 33 35 monkey monkey NN cord-291946-kq0rsuxj 33 36 , , , cord-291946-kq0rsuxj 33 37 took take VBD cord-291946-kq0rsuxj 33 38 place place NN cord-291946-kq0rsuxj 33 39 in in IN cord-291946-kq0rsuxj 33 40 primate primate JJ cord-291946-kq0rsuxj 33 41 centers center NNS cord-291946-kq0rsuxj 33 42 in in IN cord-291946-kq0rsuxj 33 43 the the DT cord-291946-kq0rsuxj 33 44 United United NNP cord-291946-kq0rsuxj 33 45 States States NNP cord-291946-kq0rsuxj 33 46 [ [ -LRB- cord-291946-kq0rsuxj 33 47 7 7 CD cord-291946-kq0rsuxj 33 48 ] ] -RRB- cord-291946-kq0rsuxj 33 49 . . . cord-291946-kq0rsuxj 34 1 Even even RB cord-291946-kq0rsuxj 34 2 more more RBR cord-291946-kq0rsuxj 34 3 dramatically dramatically RB cord-291946-kq0rsuxj 34 4 , , , cord-291946-kq0rsuxj 34 5 the the DT cord-291946-kq0rsuxj 34 6 epidemic epidemic NN cord-291946-kq0rsuxj 34 7 appearance appearance NN cord-291946-kq0rsuxj 34 8 of of IN cord-291946-kq0rsuxj 34 9 seemingly seemingly RB cord-291946-kq0rsuxj 34 10 ' ' '' cord-291946-kq0rsuxj 34 11 ' ' `` cord-291946-kq0rsuxj 34 12 new new JJ cord-291946-kq0rsuxj 34 13 ' ' '' cord-291946-kq0rsuxj 34 14 ' ' '' cord-291946-kq0rsuxj 34 15 viruses virus NNS cord-291946-kq0rsuxj 34 16 can can MD cord-291946-kq0rsuxj 34 17 be be VB cord-291946-kq0rsuxj 34 18 unwittingly unwittingly RB cord-291946-kq0rsuxj 34 19 aided aid VBN cord-291946-kq0rsuxj 34 20 by by IN cord-291946-kq0rsuxj 34 21 human human JJ cord-291946-kq0rsuxj 34 22 activities activity NNS cord-291946-kq0rsuxj 34 23 that that WDT cord-291946-kq0rsuxj 34 24 amplify amplify VBP cord-291946-kq0rsuxj 34 25 previously previously RB cord-291946-kq0rsuxj 34 26 rare rare JJ cord-291946-kq0rsuxj 34 27 viruses virus NNS cord-291946-kq0rsuxj 34 28 , , , cord-291946-kq0rsuxj 34 29 as as IN cord-291946-kq0rsuxj 34 30 was be VBD cord-291946-kq0rsuxj 34 31 seen see VBN cord-291946-kq0rsuxj 34 32 with with IN cord-291946-kq0rsuxj 34 33 the the DT cord-291946-kq0rsuxj 34 34 reuse reuse NN cord-291946-kq0rsuxj 34 35 of of IN cord-291946-kq0rsuxj 34 36 hypodermic hypodermic NN cord-291946-kq0rsuxj 34 37 needles needle NNS cord-291946-kq0rsuxj 34 38 in in IN cord-291946-kq0rsuxj 34 39 campaigns campaign NNS cord-291946-kq0rsuxj 34 40 against against IN cord-291946-kq0rsuxj 34 41 schistosomiasis schistosomiasis NN cord-291946-kq0rsuxj 34 42 ( ( -LRB- cord-291946-kq0rsuxj 34 43 snail snail NN cord-291946-kq0rsuxj 34 44 fever fever NN cord-291946-kq0rsuxj 34 45 ) ) -RRB- cord-291946-kq0rsuxj 34 46 that that WDT cord-291946-kq0rsuxj 34 47 led lead VBD cord-291946-kq0rsuxj 34 48 to to IN cord-291946-kq0rsuxj 34 49 the the DT cord-291946-kq0rsuxj 34 50 exponential exponential JJ cord-291946-kq0rsuxj 34 51 spread spread NN cord-291946-kq0rsuxj 34 52 of of IN cord-291946-kq0rsuxj 34 53 hepatitis hepatitis NN cord-291946-kq0rsuxj 34 54 C C NNP cord-291946-kq0rsuxj 34 55 virus virus NN cord-291946-kq0rsuxj 34 56 in in IN cord-291946-kq0rsuxj 34 57 Egypt Egypt NNP cord-291946-kq0rsuxj 34 58 in in IN cord-291946-kq0rsuxj 34 59 the the DT cord-291946-kq0rsuxj 34 60 mid-20th mid-20th NNS cord-291946-kq0rsuxj 34 61 century century NN cord-291946-kq0rsuxj 34 62 [ [ -LRB- cord-291946-kq0rsuxj 34 63 8 8 CD cord-291946-kq0rsuxj 34 64 ] ] -RRB- cord-291946-kq0rsuxj 34 65 , , , cord-291946-kq0rsuxj 34 66 as as RB cord-291946-kq0rsuxj 34 67 well well RB cord-291946-kq0rsuxj 34 68 as as IN cord-291946-kq0rsuxj 34 69 similar similar JJ cord-291946-kq0rsuxj 34 70 , , , cord-291946-kq0rsuxj 34 71 but but CC cord-291946-kq0rsuxj 34 72 more more RBR cord-291946-kq0rsuxj 34 73 speculative speculative JJ cord-291946-kq0rsuxj 34 74 , , , cord-291946-kq0rsuxj 34 75 theories theory NNS cord-291946-kq0rsuxj 34 76 for for IN cord-291946-kq0rsuxj 34 77 the the DT cord-291946-kq0rsuxj 34 78 amplification amplification NN cord-291946-kq0rsuxj 34 79 of of IN cord-291946-kq0rsuxj 34 80 HIV HIV NNP cord-291946-kq0rsuxj 34 81 in in IN cord-291946-kq0rsuxj 34 82 central central JJ cord-291946-kq0rsuxj 34 83 Africa Africa NNP cord-291946-kq0rsuxj 34 84 during during IN cord-291946-kq0rsuxj 34 85 campaigns campaign NNS cord-291946-kq0rsuxj 34 86 to to TO cord-291946-kq0rsuxj 34 87 eliminate eliminate VB cord-291946-kq0rsuxj 34 88 Trypanosoma Trypanosoma NNP cord-291946-kq0rsuxj 34 89 brucei brucei NNP cord-291946-kq0rsuxj 34 90 ( ( -LRB- cord-291946-kq0rsuxj 34 91 sleeping sleep VBG cord-291946-kq0rsuxj 34 92 sickness sickness NN cord-291946-kq0rsuxj 34 93 ) ) -RRB- cord-291946-kq0rsuxj 34 94 in in IN cord-291946-kq0rsuxj 34 95 the the DT cord-291946-kq0rsuxj 34 96 1920s 1920s CD cord-291946-kq0rsuxj 34 97 [ [ -LRB- cord-291946-kq0rsuxj 34 98 9 9 CD cord-291946-kq0rsuxj 34 99 ] ] -RRB- cord-291946-kq0rsuxj 34 100 . . . cord-291946-kq0rsuxj 35 1 Ultimately ultimately RB cord-291946-kq0rsuxj 35 2 , , , cord-291946-kq0rsuxj 35 3 though though RB cord-291946-kq0rsuxj 35 4 , , , cord-291946-kq0rsuxj 35 5 where where WRB cord-291946-kq0rsuxj 35 6 did do VBD cord-291946-kq0rsuxj 35 7 these these DT cord-291946-kq0rsuxj 35 8 viruses virus NNS cord-291946-kq0rsuxj 35 9 come come VB cord-291946-kq0rsuxj 35 10 from from IN cord-291946-kq0rsuxj 35 11 ? ? . cord-291946-kq0rsuxj 36 1 Fossils fossil NNS cord-291946-kq0rsuxj 36 2 of of IN cord-291946-kq0rsuxj 36 3 animals animal NNS cord-291946-kq0rsuxj 36 4 and and CC cord-291946-kq0rsuxj 36 5 plants plant NNS cord-291946-kq0rsuxj 36 6 have have VBP cord-291946-kq0rsuxj 36 7 been be VBN cord-291946-kq0rsuxj 36 8 used use VBN cord-291946-kq0rsuxj 36 9 to to TO cord-291946-kq0rsuxj 36 10 understand understand VB cord-291946-kq0rsuxj 36 11 the the DT cord-291946-kq0rsuxj 36 12 age age NN cord-291946-kq0rsuxj 36 13 of of IN cord-291946-kq0rsuxj 36 14 groups group NNS cord-291946-kq0rsuxj 36 15 of of IN cord-291946-kq0rsuxj 36 16 species specie NNS cord-291946-kq0rsuxj 36 17 . . . cord-291946-kq0rsuxj 37 1 Although although IN cord-291946-kq0rsuxj 37 2 no no DT cord-291946-kq0rsuxj 37 3 physical physical JJ cord-291946-kq0rsuxj 37 4 fossils fossil NNS cord-291946-kq0rsuxj 37 5 exist exist VBP cord-291946-kq0rsuxj 37 6 for for IN cord-291946-kq0rsuxj 37 7 viruses virus NNS cord-291946-kq0rsuxj 37 8 , , , cord-291946-kq0rsuxj 37 9 clues clue NNS cord-291946-kq0rsuxj 37 10 about about IN cord-291946-kq0rsuxj 37 11 virus virus NN cord-291946-kq0rsuxj 37 12 history history NN cord-291946-kq0rsuxj 37 13 can can MD cord-291946-kq0rsuxj 37 14 be be VB cord-291946-kq0rsuxj 37 15 gleaned glean VBN cord-291946-kq0rsuxj 37 16 from from IN cord-291946-kq0rsuxj 37 17 the the DT cord-291946-kq0rsuxj 37 18 remnants remnant NNS cord-291946-kq0rsuxj 37 19 of of IN cord-291946-kq0rsuxj 37 20 viral viral JJ cord-291946-kq0rsuxj 37 21 sequences sequence NNS cord-291946-kq0rsuxj 37 22 ( ( -LRB- cord-291946-kq0rsuxj 37 23 called call VBN cord-291946-kq0rsuxj 37 24 ' ' '' cord-291946-kq0rsuxj 37 25 ' ' `` cord-291946-kq0rsuxj 37 26 viral viral JJ cord-291946-kq0rsuxj 37 27 fossils fossil NNS cord-291946-kq0rsuxj 37 28 ' ' POS cord-291946-kq0rsuxj 37 29 ' ' '' cord-291946-kq0rsuxj 37 30 ) ) -RRB- cord-291946-kq0rsuxj 37 31 that that WDT cord-291946-kq0rsuxj 37 32 have have VBP cord-291946-kq0rsuxj 37 33 been be VBN cord-291946-kq0rsuxj 37 34 accidently accidently RB cord-291946-kq0rsuxj 37 35 inherited inherit VBN cord-291946-kq0rsuxj 37 36 in in IN cord-291946-kq0rsuxj 37 37 the the DT cord-291946-kq0rsuxj 37 38 genome genome NN cord-291946-kq0rsuxj 37 39 of of IN cord-291946-kq0rsuxj 37 40 the the DT cord-291946-kq0rsuxj 37 41 host host NN cord-291946-kq0rsuxj 37 42 they -PRON- PRP cord-291946-kq0rsuxj 37 43 infected infect VBD cord-291946-kq0rsuxj 37 44 in in IN cord-291946-kq0rsuxj 37 45 the the DT cord-291946-kq0rsuxj 37 46 past past NN cord-291946-kq0rsuxj 37 47 . . . cord-291946-kq0rsuxj 38 1 That that RB cord-291946-kq0rsuxj 38 2 is is RB cord-291946-kq0rsuxj 38 3 , , , cord-291946-kq0rsuxj 38 4 although although IN cord-291946-kq0rsuxj 38 5 viruses virus NNS cord-291946-kq0rsuxj 38 6 typically typically RB cord-291946-kq0rsuxj 38 7 spread spread VBN cord-291946-kq0rsuxj 38 8 between between IN cord-291946-kq0rsuxj 38 9 hosts host NNS cord-291946-kq0rsuxj 38 10 by by IN cord-291946-kq0rsuxj 38 11 transmission transmission NN cord-291946-kq0rsuxj 38 12 from from IN cord-291946-kq0rsuxj 38 13 one one CD cord-291946-kq0rsuxj 38 14 individual individual NN cord-291946-kq0rsuxj 38 15 to to IN cord-291946-kq0rsuxj 38 16 another another DT cord-291946-kq0rsuxj 38 17 ( ( -LRB- cord-291946-kq0rsuxj 38 18 called call VBN cord-291946-kq0rsuxj 38 19 horizontal horizontal JJ cord-291946-kq0rsuxj 38 20 transmission transmission NN cord-291946-kq0rsuxj 38 21 ) ) -RRB- cord-291946-kq0rsuxj 38 22 , , , cord-291946-kq0rsuxj 38 23 on on IN cord-291946-kq0rsuxj 38 24 rare rare JJ cord-291946-kq0rsuxj 38 25 occasions occasion NNS cord-291946-kq0rsuxj 38 26 viral viral JJ cord-291946-kq0rsuxj 38 27 nucleic nucleic JJ cord-291946-kq0rsuxj 38 28 acids acid NNS cord-291946-kq0rsuxj 38 29 can can MD cord-291946-kq0rsuxj 38 30 get get VB cord-291946-kq0rsuxj 38 31 integrated integrate VBN cord-291946-kq0rsuxj 38 32 into into IN cord-291946-kq0rsuxj 38 33 the the DT cord-291946-kq0rsuxj 38 34 host host NN cord-291946-kq0rsuxj 38 35 germline germline NN cord-291946-kq0rsuxj 38 36 and and CC cord-291946-kq0rsuxj 38 37 become become VBP cord-291946-kq0rsuxj 38 38 endogenous endogenous JJ cord-291946-kq0rsuxj 38 39 viral viral JJ cord-291946-kq0rsuxj 38 40 elements element NNS cord-291946-kq0rsuxj 38 41 ( ( -LRB- cord-291946-kq0rsuxj 38 42 EVEs EVEs NNP cord-291946-kq0rsuxj 38 43 ) ) -RRB- cord-291946-kq0rsuxj 38 44 [ [ -LRB- cord-291946-kq0rsuxj 38 45 10 10 CD cord-291946-kq0rsuxj 38 46 ] ] -RRB- cord-291946-kq0rsuxj 38 47 . . . cord-291946-kq0rsuxj 39 1 These these DT cord-291946-kq0rsuxj 39 2 EVEs eve NNS cord-291946-kq0rsuxj 39 3 can can MD cord-291946-kq0rsuxj 39 4 then then RB cord-291946-kq0rsuxj 39 5 be be VB cord-291946-kq0rsuxj 39 6 transmitted transmit VBN cord-291946-kq0rsuxj 39 7 from from IN cord-291946-kq0rsuxj 39 8 parent parent NN cord-291946-kq0rsuxj 39 9 to to IN cord-291946-kq0rsuxj 39 10 offspring offspring NN cord-291946-kq0rsuxj 39 11 ( ( -LRB- cord-291946-kq0rsuxj 39 12 called call VBN cord-291946-kq0rsuxj 39 13 vertical vertical JJ cord-291946-kq0rsuxj 39 14 transmission transmission NN cord-291946-kq0rsuxj 39 15 ) ) -RRB- cord-291946-kq0rsuxj 39 16 by by IN cord-291946-kq0rsuxj 39 17 inheritance inheritance NN cord-291946-kq0rsuxj 39 18 of of IN cord-291946-kq0rsuxj 39 19 chromosomes chromosome NNS cord-291946-kq0rsuxj 39 20 that that WDT cord-291946-kq0rsuxj 39 21 contain contain VBP cord-291946-kq0rsuxj 39 22 the the DT cord-291946-kq0rsuxj 39 23 viral viral JJ cord-291946-kq0rsuxj 39 24 DNA dna NN cord-291946-kq0rsuxj 39 25 . . . cord-291946-kq0rsuxj 40 1 At at IN cord-291946-kq0rsuxj 40 2 some some DT cord-291946-kq0rsuxj 40 3 rare rare JJ cord-291946-kq0rsuxj 40 4 frequency frequency NN cord-291946-kq0rsuxj 40 5 , , , cord-291946-kq0rsuxj 40 6 these these DT cord-291946-kq0rsuxj 40 7 inherited inherit VBN cord-291946-kq0rsuxj 40 8 EVEs eve NNS cord-291946-kq0rsuxj 40 9 become become VBP cord-291946-kq0rsuxj 40 10 present present JJ cord-291946-kq0rsuxj 40 11 in in IN cord-291946-kq0rsuxj 40 12 all all DT cord-291946-kq0rsuxj 40 13 members member NNS cord-291946-kq0rsuxj 40 14 of of IN cord-291946-kq0rsuxj 40 15 a a DT cord-291946-kq0rsuxj 40 16 species species NN cord-291946-kq0rsuxj 40 17 ( ( -LRB- cord-291946-kq0rsuxj 40 18 called call VBN cord-291946-kq0rsuxj 40 19 ' ' '' cord-291946-kq0rsuxj 40 20 ' ' `` cord-291946-kq0rsuxj 40 21 fixation fixation NN cord-291946-kq0rsuxj 40 22 ' ' '' cord-291946-kq0rsuxj 40 23 ' ' '' cord-291946-kq0rsuxj 40 24 ) ) -RRB- cord-291946-kq0rsuxj 40 25 and and CC cord-291946-kq0rsuxj 40 26 will will MD cord-291946-kq0rsuxj 40 27 evolve evolve VB cord-291946-kq0rsuxj 40 28 along along IN cord-291946-kq0rsuxj 40 29 with with IN cord-291946-kq0rsuxj 40 30 the the DT cord-291946-kq0rsuxj 40 31 host host NN cord-291946-kq0rsuxj 40 32 genome genome NN cord-291946-kq0rsuxj 40 33 over over IN cord-291946-kq0rsuxj 40 34 extended extended JJ cord-291946-kq0rsuxj 40 35 periods period NNS cord-291946-kq0rsuxj 40 36 of of IN cord-291946-kq0rsuxj 40 37 time time NN cord-291946-kq0rsuxj 40 38 ( ( -LRB- cord-291946-kq0rsuxj 40 39 Figure figure NN cord-291946-kq0rsuxj 40 40 1 1 CD cord-291946-kq0rsuxj 40 41 ) ) -RRB- cord-291946-kq0rsuxj 40 42 . . . cord-291946-kq0rsuxj 41 1 The the DT cord-291946-kq0rsuxj 41 2 analyses analysis NNS cord-291946-kq0rsuxj 41 3 of of IN cord-291946-kq0rsuxj 41 4 the the DT cord-291946-kq0rsuxj 41 5 host host NN cord-291946-kq0rsuxj 41 6 genomic genomic JJ cord-291946-kq0rsuxj 41 7 data datum NNS cord-291946-kq0rsuxj 41 8 can can MD cord-291946-kq0rsuxj 41 9 thus thus RB cord-291946-kq0rsuxj 41 10 reveal reveal VB cord-291946-kq0rsuxj 41 11 the the DT cord-291946-kq0rsuxj 41 12 presence presence NN cord-291946-kq0rsuxj 41 13 of of IN cord-291946-kq0rsuxj 41 14 these these DT cord-291946-kq0rsuxj 41 15 EVEs eve NNS cord-291946-kq0rsuxj 41 16 , , , cord-291946-kq0rsuxj 41 17 which which WDT cord-291946-kq0rsuxj 41 18 represent represent VBP cord-291946-kq0rsuxj 41 19 ' ' '' cord-291946-kq0rsuxj 41 20 ' ' `` cord-291946-kq0rsuxj 41 21 viral viral JJ cord-291946-kq0rsuxj 41 22 fossil fossil NN cord-291946-kq0rsuxj 41 23 records record NNS cord-291946-kq0rsuxj 41 24 ' ' '' cord-291946-kq0rsuxj 41 25 ' ' '' cord-291946-kq0rsuxj 41 26 and and CC cord-291946-kq0rsuxj 41 27 can can MD cord-291946-kq0rsuxj 41 28 provide provide VB cord-291946-kq0rsuxj 41 29 information information NN cord-291946-kq0rsuxj 41 30 on on IN cord-291946-kq0rsuxj 41 31 ancient ancient JJ cord-291946-kq0rsuxj 41 32 viruses virus NNS cord-291946-kq0rsuxj 41 33 ; ; : cord-291946-kq0rsuxj 41 34 together together RB cord-291946-kq0rsuxj 41 35 these these DT cord-291946-kq0rsuxj 41 36 analyses analysis NNS cord-291946-kq0rsuxj 41 37 are be VBP cord-291946-kq0rsuxj 41 38 known know VBN cord-291946-kq0rsuxj 41 39 as as IN cord-291946-kq0rsuxj 41 40 ' ' `` cord-291946-kq0rsuxj 41 41 ' ' `` cord-291946-kq0rsuxj 41 42 direct direct JJ cord-291946-kq0rsuxj 41 43 ' ' '' cord-291946-kq0rsuxj 41 44 ' ' `` cord-291946-kq0rsuxj 41 45 paleovirology paleovirology NN cord-291946-kq0rsuxj 41 46 ( ( -LRB- cord-291946-kq0rsuxj 41 47 in in IN cord-291946-kq0rsuxj 41 48 contrast contrast NN cord-291946-kq0rsuxj 41 49 to to IN cord-291946-kq0rsuxj 41 50 ' ' '' cord-291946-kq0rsuxj 41 51 ' ' `` cord-291946-kq0rsuxj 41 52 indirect indirect JJ cord-291946-kq0rsuxj 41 53 ' ' '' cord-291946-kq0rsuxj 41 54 ' ' '' cord-291946-kq0rsuxj 41 55 paleovirology paleovirology NN cord-291946-kq0rsuxj 41 56 , , , cord-291946-kq0rsuxj 41 57 which which WDT cord-291946-kq0rsuxj 41 58 instead instead RB cord-291946-kq0rsuxj 41 59 looks look VBZ cord-291946-kq0rsuxj 41 60 at at IN cord-291946-kq0rsuxj 41 61 the the DT cord-291946-kq0rsuxj 41 62 consequences consequence NNS cord-291946-kq0rsuxj 41 63 of of IN cord-291946-kq0rsuxj 41 64 ancient ancient JJ cord-291946-kq0rsuxj 41 65 viruses virus NNS cord-291946-kq0rsuxj 41 66 on on IN cord-291946-kq0rsuxj 41 67 the the DT cord-291946-kq0rsuxj 41 68 evolution evolution NN cord-291946-kq0rsuxj 41 69 of of IN cord-291946-kq0rsuxj 41 70 host host NN cord-291946-kq0rsuxj 41 71 genes gene NNS cord-291946-kq0rsuxj 41 72 ) ) -RRB- cord-291946-kq0rsuxj 41 73 [ [ -LRB- cord-291946-kq0rsuxj 41 74 11 11 CD cord-291946-kq0rsuxj 41 75 ] ] -RRB- cord-291946-kq0rsuxj 41 76 . . . cord-291946-kq0rsuxj 42 1 Determination determination NN cord-291946-kq0rsuxj 42 2 of of IN cord-291946-kq0rsuxj 42 3 the the DT cord-291946-kq0rsuxj 42 4 presence presence NN cord-291946-kq0rsuxj 42 5 or or CC cord-291946-kq0rsuxj 42 6 absence absence NN cord-291946-kq0rsuxj 42 7 of of IN cord-291946-kq0rsuxj 42 8 shared share VBN cord-291946-kq0rsuxj 42 9 EVEs eve NNS cord-291946-kq0rsuxj 42 10 in in IN cord-291946-kq0rsuxj 42 11 different different JJ cord-291946-kq0rsuxj 42 12 species specie NNS cord-291946-kq0rsuxj 42 13 can can MD cord-291946-kq0rsuxj 42 14 be be VB cord-291946-kq0rsuxj 42 15 used use VBN cord-291946-kq0rsuxj 42 16 to to TO cord-291946-kq0rsuxj 42 17 estimate estimate VB cord-291946-kq0rsuxj 42 18 the the DT cord-291946-kq0rsuxj 42 19 date date NN cord-291946-kq0rsuxj 42 20 of of IN cord-291946-kq0rsuxj 42 21 the the DT cord-291946-kq0rsuxj 42 22 viral viral JJ cord-291946-kq0rsuxj 42 23 insertion insertion NN cord-291946-kq0rsuxj 42 24 into into IN cord-291946-kq0rsuxj 42 25 the the DT cord-291946-kq0rsuxj 42 26 host host NN cord-291946-kq0rsuxj 42 27 genome genome NN cord-291946-kq0rsuxj 42 28 [ [ -LRB- cord-291946-kq0rsuxj 42 29 10 10 CD cord-291946-kq0rsuxj 42 30 ] ] -RRB- cord-291946-kq0rsuxj 42 31 and and CC cord-291946-kq0rsuxj 42 32 to to TO cord-291946-kq0rsuxj 42 33 infer infer VB cord-291946-kq0rsuxj 42 34 the the DT cord-291946-kq0rsuxj 42 35 presence presence NN cord-291946-kq0rsuxj 42 36 of of IN cord-291946-kq0rsuxj 42 37 an an DT cord-291946-kq0rsuxj 42 38 ancient ancient JJ cord-291946-kq0rsuxj 42 39 circulating circulate VBG cord-291946-kq0rsuxj 42 40 virus virus NN cord-291946-kq0rsuxj 42 41 among among IN cord-291946-kq0rsuxj 42 42 certain certain JJ cord-291946-kq0rsuxj 42 43 hosts host NNS cord-291946-kq0rsuxj 42 44 over over IN cord-291946-kq0rsuxj 42 45 a a DT cord-291946-kq0rsuxj 42 46 very very RB cord-291946-kq0rsuxj 42 47 long long JJ cord-291946-kq0rsuxj 42 48 period period NN cord-291946-kq0rsuxj 42 49 of of IN cord-291946-kq0rsuxj 42 50 time time NN cord-291946-kq0rsuxj 42 51 ( ( -LRB- cord-291946-kq0rsuxj 42 52 Figure figure NN cord-291946-kq0rsuxj 42 53 1 1 CD cord-291946-kq0rsuxj 42 54 ) ) -RRB- cord-291946-kq0rsuxj 42 55 . . . cord-291946-kq0rsuxj 43 1 For for IN cord-291946-kq0rsuxj 43 2 example example NN cord-291946-kq0rsuxj 43 3 , , , cord-291946-kq0rsuxj 43 4 the the DT cord-291946-kq0rsuxj 43 5 analyses analysis NNS cord-291946-kq0rsuxj 43 6 of of IN cord-291946-kq0rsuxj 43 7 EVEs eve NNS cord-291946-kq0rsuxj 43 8 among among IN cord-291946-kq0rsuxj 43 9 different different JJ cord-291946-kq0rsuxj 43 10 species specie NNS cord-291946-kq0rsuxj 43 11 showed show VBD cord-291946-kq0rsuxj 43 12 that that IN cord-291946-kq0rsuxj 43 13 a a DT cord-291946-kq0rsuxj 43 14 relative relative NN cord-291946-kq0rsuxj 43 15 of of IN cord-291946-kq0rsuxj 43 16 the the DT cord-291946-kq0rsuxj 43 17 hepatitis hepatitis NN cord-291946-kq0rsuxj 43 18 B B NNP cord-291946-kq0rsuxj 43 19 virus virus NN cord-291946-kq0rsuxj 43 20 that that WDT cord-291946-kq0rsuxj 43 21 currently currently RB cord-291946-kq0rsuxj 43 22 infects infect VBZ cord-291946-kq0rsuxj 43 23 humans human NNS cord-291946-kq0rsuxj 43 24 was be VBD cord-291946-kq0rsuxj 43 25 present present JJ cord-291946-kq0rsuxj 43 26 in in IN cord-291946-kq0rsuxj 43 27 the the DT cord-291946-kq0rsuxj 43 28 passerine passerine JJ cord-291946-kq0rsuxj 43 29 birds bird NNS cord-291946-kq0rsuxj 43 30 at at RB cord-291946-kq0rsuxj 43 31 least least RBS cord-291946-kq0rsuxj 43 32 19 19 CD cord-291946-kq0rsuxj 43 33 million million CD cord-291946-kq0rsuxj 43 34 years year NNS cord-291946-kq0rsuxj 43 35 ago ago RB cord-291946-kq0rsuxj 43 36 [ [ -LRB- cord-291946-kq0rsuxj 43 37 12 12 CD cord-291946-kq0rsuxj 43 38 ] ] -RRB- cord-291946-kq0rsuxj 43 39 . . . cord-291946-kq0rsuxj 44 1 Importantly importantly RB cord-291946-kq0rsuxj 44 2 , , , cord-291946-kq0rsuxj 44 3 because because IN cord-291946-kq0rsuxj 44 4 integration integration NN cord-291946-kq0rsuxj 44 5 in in IN cord-291946-kq0rsuxj 44 6 the the DT cord-291946-kq0rsuxj 44 7 host host NN cord-291946-kq0rsuxj 44 8 cell cell NN cord-291946-kq0rsuxj 44 9 chromosome chromosome NN cord-291946-kq0rsuxj 44 10 is be VBZ cord-291946-kq0rsuxj 44 11 an an DT cord-291946-kq0rsuxj 44 12 obligate obligate JJ cord-291946-kq0rsuxj 44 13 part part NN cord-291946-kq0rsuxj 44 14 of of IN cord-291946-kq0rsuxj 44 15 the the DT cord-291946-kq0rsuxj 44 16 lifecycle lifecycle NN cord-291946-kq0rsuxj 44 17 of of IN cord-291946-kq0rsuxj 44 18 retroviruses retrovirus NNS cord-291946-kq0rsuxj 44 19 , , , cord-291946-kq0rsuxj 44 20 the the DT cord-291946-kq0rsuxj 44 21 catalog catalog NN cord-291946-kq0rsuxj 44 22 of of IN cord-291946-kq0rsuxj 44 23 endogenous endogenous JJ cord-291946-kq0rsuxj 44 24 retroviral retroviral NN cord-291946-kq0rsuxj 44 25 elements element NNS cord-291946-kq0rsuxj 44 26 provides provide VBZ cord-291946-kq0rsuxj 44 27 an an DT cord-291946-kq0rsuxj 44 28 especially especially RB cord-291946-kq0rsuxj 44 29 rich rich JJ cord-291946-kq0rsuxj 44 30 record record NN cord-291946-kq0rsuxj 44 31 of of IN cord-291946-kq0rsuxj 44 32 past past JJ cord-291946-kq0rsuxj 44 33 retroviral retroviral JJ cord-291946-kq0rsuxj 44 34 infections infection NNS cord-291946-kq0rsuxj 44 35 ( ( -LRB- cord-291946-kq0rsuxj 44 36 for for IN cord-291946-kq0rsuxj 44 37 example example NN cord-291946-kq0rsuxj 44 38 , , , cord-291946-kq0rsuxj 44 39 [ [ -LRB- cord-291946-kq0rsuxj 44 40 13 13 CD cord-291946-kq0rsuxj 44 41 ] ] -RRB- cord-291946-kq0rsuxj 44 42 ) ) -RRB- cord-291946-kq0rsuxj 44 43 . . . cord-291946-kq0rsuxj 45 1 Among among IN cord-291946-kq0rsuxj 45 2 retroviruses retrovirus NNS cord-291946-kq0rsuxj 45 3 , , , cord-291946-kq0rsuxj 45 4 a a DT cord-291946-kq0rsuxj 45 5 group group NN cord-291946-kq0rsuxj 45 6 of of IN cord-291946-kq0rsuxj 45 7 viruses virus NNS cord-291946-kq0rsuxj 45 8 related relate VBN cord-291946-kq0rsuxj 45 9 to to IN cord-291946-kq0rsuxj 45 10 the the DT cord-291946-kq0rsuxj 45 11 reticuloendotheliosis reticuloendotheliosis NN cord-291946-kq0rsuxj 45 12 virus virus NN cord-291946-kq0rsuxj 45 13 ( ( -LRB- cord-291946-kq0rsuxj 45 14 REV REV NNP cord-291946-kq0rsuxj 45 15 ) ) -RRB- cord-291946-kq0rsuxj 45 16 has have VBZ cord-291946-kq0rsuxj 45 17 especially especially RB cord-291946-kq0rsuxj 45 18 interesting interesting JJ cord-291946-kq0rsuxj 45 19 ancestral ancestral JJ cord-291946-kq0rsuxj 45 20 origins origin NNS cord-291946-kq0rsuxj 45 21 . . . cord-291946-kq0rsuxj 46 1 REV REV NNP cord-291946-kq0rsuxj 46 2 currently currently RB cord-291946-kq0rsuxj 46 3 circulates circulate VBZ cord-291946-kq0rsuxj 46 4 in in IN cord-291946-kq0rsuxj 46 5 chickens chicken NNS cord-291946-kq0rsuxj 46 6 , , , cord-291946-kq0rsuxj 46 7 turkeys turkey NNS cord-291946-kq0rsuxj 46 8 , , , cord-291946-kq0rsuxj 46 9 pheasants pheasant NNS cord-291946-kq0rsuxj 46 10 , , , cord-291946-kq0rsuxj 46 11 ducks duck NNS cord-291946-kq0rsuxj 46 12 , , , cord-291946-kq0rsuxj 46 13 and and CC cord-291946-kq0rsuxj 46 14 geese goose NNS cord-291946-kq0rsuxj 46 15 , , , cord-291946-kq0rsuxj 46 16 where where WRB cord-291946-kq0rsuxj 46 17 it -PRON- PRP cord-291946-kq0rsuxj 46 18 sometimes sometimes RB cord-291946-kq0rsuxj 46 19 causes cause VBZ cord-291946-kq0rsuxj 46 20 disease disease NN cord-291946-kq0rsuxj 46 21 . . . cord-291946-kq0rsuxj 47 1 However however RB cord-291946-kq0rsuxj 47 2 , , , cord-291946-kq0rsuxj 47 3 its -PRON- PRP$ cord-291946-kq0rsuxj 47 4 genome genome NN cord-291946-kq0rsuxj 47 5 is be VBZ cord-291946-kq0rsuxj 47 6 not not RB cord-291946-kq0rsuxj 47 7 related relate VBN cord-291946-kq0rsuxj 47 8 to to IN cord-291946-kq0rsuxj 47 9 other other JJ cord-291946-kq0rsuxj 47 10 avian avian JJ cord-291946-kq0rsuxj 47 11 retroviruses retrovirus NNS cord-291946-kq0rsuxj 47 12 ; ; : cord-291946-kq0rsuxj 47 13 rather rather RB cord-291946-kq0rsuxj 47 14 , , , cord-291946-kq0rsuxj 47 15 it -PRON- PRP cord-291946-kq0rsuxj 47 16 is be VBZ cord-291946-kq0rsuxj 47 17 most most RBS cord-291946-kq0rsuxj 47 18 closely closely RB cord-291946-kq0rsuxj 47 19 related related JJ cord-291946-kq0rsuxj 47 20 to to IN cord-291946-kq0rsuxj 47 21 some some DT cord-291946-kq0rsuxj 47 22 mammalian mammalian JJ cord-291946-kq0rsuxj 47 23 retroviruses retrovirus NNS cord-291946-kq0rsuxj 47 24 [ [ -LRB- cord-291946-kq0rsuxj 47 25 14 14 CD cord-291946-kq0rsuxj 47 26 ] ] -RRB- cord-291946-kq0rsuxj 47 27 . . . cord-291946-kq0rsuxj 48 1 This this DT cord-291946-kq0rsuxj 48 2 is be VBZ cord-291946-kq0rsuxj 48 3 unusual unusual JJ cord-291946-kq0rsuxj 48 4 because because IN cord-291946-kq0rsuxj 48 5 retroviral retroviral JJ cord-291946-kq0rsuxj 48 6 transmissions transmission NNS cord-291946-kq0rsuxj 48 7 between between IN cord-291946-kq0rsuxj 48 8 different different JJ cord-291946-kq0rsuxj 48 9 classes class NNS cord-291946-kq0rsuxj 48 10 of of IN cord-291946-kq0rsuxj 48 11 animals animal NNS cord-291946-kq0rsuxj 48 12 ( ( -LRB- cord-291946-kq0rsuxj 48 13 e.g. e.g. RB cord-291946-kq0rsuxj 48 14 , , , cord-291946-kq0rsuxj 48 15 between between IN cord-291946-kq0rsuxj 48 16 birds bird NNS cord-291946-kq0rsuxj 48 17 and and CC cord-291946-kq0rsuxj 48 18 mammals mammal NNS cord-291946-kq0rsuxj 48 19 ) ) -RRB- cord-291946-kq0rsuxj 48 20 , , , cord-291946-kq0rsuxj 48 21 called call VBN cord-291946-kq0rsuxj 48 22 inter inter JJ cord-291946-kq0rsuxj 48 23 - - JJ cord-291946-kq0rsuxj 48 24 class class JJ cord-291946-kq0rsuxj 48 25 transmissions transmission NNS cord-291946-kq0rsuxj 48 26 , , , cord-291946-kq0rsuxj 48 27 are be VBP cord-291946-kq0rsuxj 48 28 much much RB cord-291946-kq0rsuxj 48 29 more more RBR cord-291946-kq0rsuxj 48 30 difficult difficult JJ cord-291946-kq0rsuxj 48 31 than than IN cord-291946-kq0rsuxj 48 32 those those DT cord-291946-kq0rsuxj 48 33 between between IN cord-291946-kq0rsuxj 48 34 closely closely RB cord-291946-kq0rsuxj 48 35 related relate VBN cord-291946-kq0rsuxj 48 36 species specie NNS cord-291946-kq0rsuxj 48 37 and and CC cord-291946-kq0rsuxj 48 38 are be VBP cord-291946-kq0rsuxj 48 39 often often RB cord-291946-kq0rsuxj 48 40 dead dead JJ cord-291946-kq0rsuxj 48 41 ends end NNS cord-291946-kq0rsuxj 48 42 [ [ -LRB- cord-291946-kq0rsuxj 48 43 15 15 CD cord-291946-kq0rsuxj 48 44 ] ] -RRB- cord-291946-kq0rsuxj 48 45 . . . cord-291946-kq0rsuxj 49 1 Indeed indeed RB cord-291946-kq0rsuxj 49 2 , , , cord-291946-kq0rsuxj 49 3 the the DT cord-291946-kq0rsuxj 49 4 virus virus NN cord-291946-kq0rsuxj 49 5 needs need VBZ cord-291946-kq0rsuxj 49 6 to to TO cord-291946-kq0rsuxj 49 7 adapt adapt VB cord-291946-kq0rsuxj 49 8 to to IN cord-291946-kq0rsuxj 49 9 large large JJ cord-291946-kq0rsuxj 49 10 differences difference NNS cord-291946-kq0rsuxj 49 11 between between IN cord-291946-kq0rsuxj 49 12 the the DT cord-291946-kq0rsuxj 49 13 host host NN cord-291946-kq0rsuxj 49 14 species species NN cord-291946-kq0rsuxj 49 15 that that WDT cord-291946-kq0rsuxj 49 16 will will MD cord-291946-kq0rsuxj 49 17 include include VB cord-291946-kq0rsuxj 49 18 , , , cord-291946-kq0rsuxj 49 19 among among IN cord-291946-kq0rsuxj 49 20 many many JJ cord-291946-kq0rsuxj 49 21 other other JJ cord-291946-kq0rsuxj 49 22 things thing NNS cord-291946-kq0rsuxj 49 23 , , , cord-291946-kq0rsuxj 49 24 differences difference NNS cord-291946-kq0rsuxj 49 25 in in IN cord-291946-kq0rsuxj 49 26 the the DT cord-291946-kq0rsuxj 49 27 host host NN cord-291946-kq0rsuxj 49 28 cell cell NN cord-291946-kq0rsuxj 49 29 receptors receptor NNS cord-291946-kq0rsuxj 49 30 to to TO cord-291946-kq0rsuxj 49 31 allow allow VB cord-291946-kq0rsuxj 49 32 the the DT cord-291946-kq0rsuxj 49 33 virus virus NN cord-291946-kq0rsuxj 49 34 to to TO cord-291946-kq0rsuxj 49 35 enter enter VB cord-291946-kq0rsuxj 49 36 the the DT cord-291946-kq0rsuxj 49 37 cells cell NNS cord-291946-kq0rsuxj 49 38 , , , cord-291946-kq0rsuxj 49 39 differences difference NNS cord-291946-kq0rsuxj 49 40 in in IN cord-291946-kq0rsuxj 49 41 the the DT cord-291946-kq0rsuxj 49 42 host host NN cord-291946-kq0rsuxj 49 43 cell cell NN cord-291946-kq0rsuxj 49 44 environment environment NN cord-291946-kq0rsuxj 49 45 ( ( -LRB- cord-291946-kq0rsuxj 49 46 e.g. e.g. RB cord-291946-kq0rsuxj 49 47 , , , cord-291946-kq0rsuxj 49 48 temperature temperature NN cord-291946-kq0rsuxj 49 49 ) ) -RRB- cord-291946-kq0rsuxj 49 50 that that IN cord-291946-kq0rsuxj 49 51 the the DT cord-291946-kq0rsuxj 49 52 virus virus NN cord-291946-kq0rsuxj 49 53 needs need VBZ cord-291946-kq0rsuxj 49 54 to to TO cord-291946-kq0rsuxj 49 55 replicate replicate VB cord-291946-kq0rsuxj 49 56 , , , cord-291946-kq0rsuxj 49 57 and and CC cord-291946-kq0rsuxj 49 58 different different JJ cord-291946-kq0rsuxj 49 59 sets set NNS cord-291946-kq0rsuxj 49 60 of of IN cord-291946-kq0rsuxj 49 61 immune immune JJ cord-291946-kq0rsuxj 49 62 defense defense NN cord-291946-kq0rsuxj 49 63 proteins protein NNS cord-291946-kq0rsuxj 49 64 . . . cord-291946-kq0rsuxj 50 1 One one CD cord-291946-kq0rsuxj 50 2 hypothesis hypothesis NN cord-291946-kq0rsuxj 50 3 is be VBZ cord-291946-kq0rsuxj 50 4 that that IN cord-291946-kq0rsuxj 50 5 REV REV NNP cord-291946-kq0rsuxj 50 6 may may MD cord-291946-kq0rsuxj 50 7 have have VB cord-291946-kq0rsuxj 50 8 been be VBN cord-291946-kq0rsuxj 50 9 aided aid VBN cord-291946-kq0rsuxj 50 10 in in IN cord-291946-kq0rsuxj 50 11 its -PRON- PRP$ cord-291946-kq0rsuxj 50 12 ability ability NN cord-291946-kq0rsuxj 50 13 to to TO cord-291946-kq0rsuxj 50 14 move move VB cord-291946-kq0rsuxj 50 15 between between IN cord-291946-kq0rsuxj 50 16 very very RB cord-291946-kq0rsuxj 50 17 different different JJ cord-291946-kq0rsuxj 50 18 species specie NNS cord-291946-kq0rsuxj 50 19 because because IN cord-291946-kq0rsuxj 50 20 it -PRON- PRP cord-291946-kq0rsuxj 50 21 is be VBZ cord-291946-kq0rsuxj 50 22 a a DT cord-291946-kq0rsuxj 50 23 an an DT cord-291946-kq0rsuxj 50 24 unusual unusual JJ cord-291946-kq0rsuxj 50 25 recombinant recombinant JJ cord-291946-kq0rsuxj 50 26 virus virus NN cord-291946-kq0rsuxj 50 27 between between IN cord-291946-kq0rsuxj 50 28 two two CD cord-291946-kq0rsuxj 50 29 different different JJ cord-291946-kq0rsuxj 50 30 retrovirus retrovirus NN cord-291946-kq0rsuxj 50 31 genera genera VBP cord-291946-kq0rsuxj 50 32 ; ; : cord-291946-kq0rsuxj 50 33 some some DT cord-291946-kq0rsuxj 50 34 of of IN cord-291946-kq0rsuxj 50 35 the the DT cord-291946-kq0rsuxj 50 36 REV REV NNP cord-291946-kq0rsuxj 50 37 genes gene NNS cord-291946-kq0rsuxj 50 38 are be VBP cord-291946-kq0rsuxj 50 39 related relate VBN cord-291946-kq0rsuxj 50 40 to to IN cord-291946-kq0rsuxj 50 41 gammaretroviruses gammaretroviruse NNS cord-291946-kq0rsuxj 50 42 , , , cord-291946-kq0rsuxj 50 43 while while IN cord-291946-kq0rsuxj 50 44 the the DT cord-291946-kq0rsuxj 50 45 viral viral JJ cord-291946-kq0rsuxj 50 46 gene gene NN cord-291946-kq0rsuxj 50 47 that that WDT cord-291946-kq0rsuxj 50 48 encodes encode VBZ cord-291946-kq0rsuxj 50 49 the the DT cord-291946-kq0rsuxj 50 50 protein protein NN cord-291946-kq0rsuxj 50 51 that that WDT cord-291946-kq0rsuxj 50 52 allows allow VBZ cord-291946-kq0rsuxj 50 53 it -PRON- PRP cord-291946-kq0rsuxj 50 54 to to TO cord-291946-kq0rsuxj 50 55 enter enter VB cord-291946-kq0rsuxj 50 56 cells cell NNS cord-291946-kq0rsuxj 50 57 is be VBZ cord-291946-kq0rsuxj 50 58 derived derive VBN cord-291946-kq0rsuxj 50 59 from from IN cord-291946-kq0rsuxj 50 60 beta beta NN cord-291946-kq0rsuxj 50 61 - - HYPH cord-291946-kq0rsuxj 50 62 retroviruses retrovirus NNS cord-291946-kq0rsuxj 50 63 [ [ -LRB- cord-291946-kq0rsuxj 50 64 14 14 CD cord-291946-kq0rsuxj 50 65 ] ] -RRB- cord-291946-kq0rsuxj 50 66 . . . cord-291946-kq0rsuxj 51 1 There there EX cord-291946-kq0rsuxj 51 2 are be VBP cord-291946-kq0rsuxj 51 3 several several JJ cord-291946-kq0rsuxj 51 4 important important JJ cord-291946-kq0rsuxj 51 5 biological biological JJ cord-291946-kq0rsuxj 51 6 differences difference NNS cord-291946-kq0rsuxj 51 7 between between IN cord-291946-kq0rsuxj 51 8 gammaretroviruses gammaretroviruse NNS cord-291946-kq0rsuxj 51 9 and and CC cord-291946-kq0rsuxj 51 10 beta beta NN cord-291946-kq0rsuxj 51 11 - - HYPH cord-291946-kq0rsuxj 51 12 retroviruses retrovirus NNS cord-291946-kq0rsuxj 51 13 , , , cord-291946-kq0rsuxj 51 14 but but CC cord-291946-kq0rsuxj 51 15 one one NN cord-291946-kq0rsuxj 51 16 that that WDT cord-291946-kq0rsuxj 51 17 may may MD cord-291946-kq0rsuxj 51 18 be be VB cord-291946-kq0rsuxj 51 19 important important JJ cord-291946-kq0rsuxj 51 20 in in IN cord-291946-kq0rsuxj 51 21 understanding understand VBG cord-291946-kq0rsuxj 51 22 the the DT cord-291946-kq0rsuxj 51 23 origins origin NNS cord-291946-kq0rsuxj 51 24 of of IN cord-291946-kq0rsuxj 51 25 REV REV NNP cord-291946-kq0rsuxj 51 26 is be VBZ cord-291946-kq0rsuxj 51 27 that that IN cord-291946-kq0rsuxj 51 28 the the DT cord-291946-kq0rsuxj 51 29 gammaretroviruses gammaretroviruse NNS cord-291946-kq0rsuxj 51 30 do do VBP cord-291946-kq0rsuxj 51 31 not not RB cord-291946-kq0rsuxj 51 32 generally generally RB cord-291946-kq0rsuxj 51 33 undergo undergo VB cord-291946-kq0rsuxj 51 34 inter inter JJ cord-291946-kq0rsuxj 51 35 - - JJ cord-291946-kq0rsuxj 51 36 class class JJ cord-291946-kq0rsuxj 51 37 transmissions transmission NNS cord-291946-kq0rsuxj 51 38 , , , cord-291946-kq0rsuxj 51 39 while while IN cord-291946-kq0rsuxj 51 40 the the DT cord-291946-kq0rsuxj 51 41 fossil fossil JJ cord-291946-kq0rsuxj 51 42 records record NNS cord-291946-kq0rsuxj 51 43 of of IN cord-291946-kq0rsuxj 51 44 beta beta NN cord-291946-kq0rsuxj 51 45 - - HYPH cord-291946-kq0rsuxj 51 46 retroviruses retrovirus NNS cord-291946-kq0rsuxj 51 47 show show VBP cord-291946-kq0rsuxj 51 48 more more JJR cord-291946-kq0rsuxj 51 49 propensity propensity NN cord-291946-kq0rsuxj 51 50 for for IN cord-291946-kq0rsuxj 51 51 large large JJ cord-291946-kq0rsuxj 51 52 species specie NNS cord-291946-kq0rsuxj 51 53 jumps jump VBZ cord-291946-kq0rsuxj 51 54 [ [ -LRB- cord-291946-kq0rsuxj 51 55 16 16 CD cord-291946-kq0rsuxj 51 56 ] ] -RRB- cord-291946-kq0rsuxj 51 57 [ [ -LRB- cord-291946-kq0rsuxj 51 58 17 17 CD cord-291946-kq0rsuxj 51 59 ] ] -RRB- cord-291946-kq0rsuxj 51 60 [ [ -LRB- cord-291946-kq0rsuxj 51 61 18 18 CD cord-291946-kq0rsuxj 51 62 ] ] -RRB- cord-291946-kq0rsuxj 51 63 . . . cord-291946-kq0rsuxj 52 1 Finally finally RB cord-291946-kq0rsuxj 52 2 , , , cord-291946-kq0rsuxj 52 3 REV REV NNP cord-291946-kq0rsuxj 52 4 is be VBZ cord-291946-kq0rsuxj 52 5 unusual unusual JJ cord-291946-kq0rsuxj 52 6 in in IN cord-291946-kq0rsuxj 52 7 having have VBG cord-291946-kq0rsuxj 52 8 integrated integrate VBN cord-291946-kq0rsuxj 52 9 itself -PRON- PRP cord-291946-kq0rsuxj 52 10 into into IN cord-291946-kq0rsuxj 52 11 two two CD cord-291946-kq0rsuxj 52 12 other other JJ cord-291946-kq0rsuxj 52 13 large large JJ cord-291946-kq0rsuxj 52 14 DNA dna NN cord-291946-kq0rsuxj 52 15 viruses virus NNS cord-291946-kq0rsuxj 52 16 : : : cord-291946-kq0rsuxj 52 17 a a DT cord-291946-kq0rsuxj 52 18 herpesvirus herpesvirus NN cord-291946-kq0rsuxj 52 19 , , , cord-291946-kq0rsuxj 52 20 which which WDT cord-291946-kq0rsuxj 52 21 replicates replicate VBZ cord-291946-kq0rsuxj 52 22 in in IN cord-291946-kq0rsuxj 52 23 the the DT cord-291946-kq0rsuxj 52 24 nucleus nucleus NN cord-291946-kq0rsuxj 52 25 , , , cord-291946-kq0rsuxj 52 26 and and CC cord-291946-kq0rsuxj 52 27 a a DT cord-291946-kq0rsuxj 52 28 poxvirus poxvirus NN cord-291946-kq0rsuxj 52 29 , , , cord-291946-kq0rsuxj 52 30 which which WDT cord-291946-kq0rsuxj 52 31 replicates replicate VBZ cord-291946-kq0rsuxj 52 32 in in IN cord-291946-kq0rsuxj 52 33 the the DT cord-291946-kq0rsuxj 52 34 cytoplasm cytoplasm NN cord-291946-kq0rsuxj 52 35 [ [ -LRB- cord-291946-kq0rsuxj 52 36 19 19 CD cord-291946-kq0rsuxj 52 37 , , , cord-291946-kq0rsuxj 52 38 20 20 CD cord-291946-kq0rsuxj 52 39 ] ] -RRB- cord-291946-kq0rsuxj 52 40 . . . cord-291946-kq0rsuxj 53 1 The the DT cord-291946-kq0rsuxj 53 2 concept concept NN cord-291946-kq0rsuxj 53 3 is be VBZ cord-291946-kq0rsuxj 53 4 illustrated illustrate VBN cord-291946-kq0rsuxj 53 5 with with IN cord-291946-kq0rsuxj 53 6 the the DT cord-291946-kq0rsuxj 53 7 example example NN cord-291946-kq0rsuxj 53 8 of of IN cord-291946-kq0rsuxj 53 9 the the DT cord-291946-kq0rsuxj 53 10 viral viral JJ cord-291946-kq0rsuxj 53 11 fossil fossil NN cord-291946-kq0rsuxj 53 12 record record NN cord-291946-kq0rsuxj 53 13 and and CC cord-291946-kq0rsuxj 53 14 evolutionary evolutionary JJ cord-291946-kq0rsuxj 53 15 history history NN cord-291946-kq0rsuxj 53 16 of of IN cord-291946-kq0rsuxj 53 17 the the DT cord-291946-kq0rsuxj 53 18 reticuloendotheliosis reticuloendotheliosis NNP cord-291946-kq0rsuxj 53 19 virus virus NN cord-291946-kq0rsuxj 53 20 ( ( -LRB- cord-291946-kq0rsuxj 53 21 REV REV NNP cord-291946-kq0rsuxj 53 22 ) ) -RRB- cord-291946-kq0rsuxj 53 23 . . . cord-291946-kq0rsuxj 54 1 The the DT cord-291946-kq0rsuxj 54 2 tree tree NN cord-291946-kq0rsuxj 54 3 is be VBZ cord-291946-kq0rsuxj 54 4 a a DT cord-291946-kq0rsuxj 54 5 timescaled timescaled JJ cord-291946-kq0rsuxj 54 6 representation representation NN cord-291946-kq0rsuxj 54 7 of of IN cord-291946-kq0rsuxj 54 8 a a DT cord-291946-kq0rsuxj 54 9 host host NN cord-291946-kq0rsuxj 54 10 genome genome NN cord-291946-kq0rsuxj 54 11 phylogeny phylogeny NN cord-291946-kq0rsuxj 54 12 . . . cord-291946-kq0rsuxj 55 1 Hosts host NNS cord-291946-kq0rsuxj 55 2 for for IN cord-291946-kq0rsuxj 55 3 which which WDT cord-291946-kq0rsuxj 55 4 genomic genomic JJ cord-291946-kq0rsuxj 55 5 sequences sequence NNS cord-291946-kq0rsuxj 55 6 are be VBP cord-291946-kq0rsuxj 55 7 available available JJ cord-291946-kq0rsuxj 55 8 are be VBP cord-291946-kq0rsuxj 55 9 depicted depict VBN cord-291946-kq0rsuxj 55 10 in in IN cord-291946-kq0rsuxj 55 11 white white JJ cord-291946-kq0rsuxj 55 12 , , , cord-291946-kq0rsuxj 55 13 while while IN cord-291946-kq0rsuxj 55 14 hosts host NNS cord-291946-kq0rsuxj 55 15 that that WDT cord-291946-kq0rsuxj 55 16 do do VBP cord-291946-kq0rsuxj 55 17 not not RB cord-291946-kq0rsuxj 55 18 have have VB cord-291946-kq0rsuxj 55 19 genome genome NN cord-291946-kq0rsuxj 55 20 data datum NNS cord-291946-kq0rsuxj 55 21 available available JJ cord-291946-kq0rsuxj 55 22 are be VBP cord-291946-kq0rsuxj 55 23 represented represent VBN cord-291946-kq0rsuxj 55 24 in in IN cord-291946-kq0rsuxj 55 25 plain plain JJ cord-291946-kq0rsuxj 55 26 black black NN cord-291946-kq0rsuxj 55 27 . . . cord-291946-kq0rsuxj 56 1 The the DT cord-291946-kq0rsuxj 56 2 hosts host NNS cord-291946-kq0rsuxj 56 3 that that WDT cord-291946-kq0rsuxj 56 4 harbor harbor VBP cord-291946-kq0rsuxj 56 5 a a DT cord-291946-kq0rsuxj 56 6 REV REV NNP cord-291946-kq0rsuxj 56 7 - - HYPH cord-291946-kq0rsuxj 56 8 like like JJ cord-291946-kq0rsuxj 56 9 endogenous endogenous JJ cord-291946-kq0rsuxj 56 10 element element NN cord-291946-kq0rsuxj 56 11 are be VBP cord-291946-kq0rsuxj 56 12 depicted depict VBN cord-291946-kq0rsuxj 56 13 , , , cord-291946-kq0rsuxj 56 14 as as RB cord-291946-kq0rsuxj 56 15 well well RB cord-291946-kq0rsuxj 56 16 as as IN cord-291946-kq0rsuxj 56 17 those those DT cord-291946-kq0rsuxj 56 18 from from IN cord-291946-kq0rsuxj 56 19 which which WDT cord-291946-kq0rsuxj 56 20 information information NN cord-291946-kq0rsuxj 56 21 is be VBZ cord-291946-kq0rsuxj 56 22 not not RB cord-291946-kq0rsuxj 56 23 available available JJ cord-291946-kq0rsuxj 56 24 ( ( -LRB- cord-291946-kq0rsuxj 56 25 question question NN cord-291946-kq0rsuxj 56 26 marks mark NNS cord-291946-kq0rsuxj 56 27 ) ) -RRB- cord-291946-kq0rsuxj 56 28 and and CC cord-291946-kq0rsuxj 56 29 others other NNS cord-291946-kq0rsuxj 56 30 from from IN cord-291946-kq0rsuxj 56 31 which which WDT cord-291946-kq0rsuxj 56 32 the the DT cord-291946-kq0rsuxj 56 33 EVE EVE NNP cord-291946-kq0rsuxj 56 34 is be VBZ cord-291946-kq0rsuxj 56 35 absent absent JJ cord-291946-kq0rsuxj 56 36 . . . cord-291946-kq0rsuxj 57 1 Regions region NNS cord-291946-kq0rsuxj 57 2 in in IN cord-291946-kq0rsuxj 57 3 green green JJ cord-291946-kq0rsuxj 57 4 represent represent VBP cord-291946-kq0rsuxj 57 5 the the DT cord-291946-kq0rsuxj 57 6 EVE EVE NNP cord-291946-kq0rsuxj 57 7 flanking flank VBG cord-291946-kq0rsuxj 57 8 region region NN cord-291946-kq0rsuxj 57 9 . . . cord-291946-kq0rsuxj 58 1 The the DT cord-291946-kq0rsuxj 58 2 time time NN cord-291946-kq0rsuxj 58 3 frame frame NN cord-291946-kq0rsuxj 58 4 in in IN cord-291946-kq0rsuxj 58 5 which which WDT cord-291946-kq0rsuxj 58 6 an an DT cord-291946-kq0rsuxj 58 7 exogenous exogenous JJ cord-291946-kq0rsuxj 58 8 mammalian mammalian JJ cord-291946-kq0rsuxj 58 9 virus virus NN cord-291946-kq0rsuxj 58 10 ( ( -LRB- cord-291946-kq0rsuxj 58 11 1 1 CD cord-291946-kq0rsuxj 58 12 ) ) -RRB- cord-291946-kq0rsuxj 58 13 , , , cord-291946-kq0rsuxj 58 14 here here RB cord-291946-kq0rsuxj 58 15 REV REV NNP cord-291946-kq0rsuxj 58 16 , , , cord-291946-kq0rsuxj 58 17 integrated integrate VBN cord-291946-kq0rsuxj 58 18 in in IN cord-291946-kq0rsuxj 58 19 the the DT cord-291946-kq0rsuxj 58 20 host host NN cord-291946-kq0rsuxj 58 21 germline germline NN cord-291946-kq0rsuxj 58 22 ( ( -LRB- cord-291946-kq0rsuxj 58 23 2 2 CD cord-291946-kq0rsuxj 58 24 ) ) -RRB- cord-291946-kq0rsuxj 58 25 and and CC cord-291946-kq0rsuxj 58 26 reached reach VBN cord-291946-kq0rsuxj 58 27 fixation fixation NN cord-291946-kq0rsuxj 58 28 ( ( -LRB- cord-291946-kq0rsuxj 58 29 3 3 CD cord-291946-kq0rsuxj 58 30 ) ) -RRB- cord-291946-kq0rsuxj 58 31 is be VBZ cord-291946-kq0rsuxj 58 32 represented represent VBN cord-291946-kq0rsuxj 58 33 . . . cord-291946-kq0rsuxj 59 1 The the DT cord-291946-kq0rsuxj 59 2 presence presence NN cord-291946-kq0rsuxj 59 3 of of IN cord-291946-kq0rsuxj 59 4 related related JJ cord-291946-kq0rsuxj 59 5 EVEs eve NNS cord-291946-kq0rsuxj 59 6 at at IN cord-291946-kq0rsuxj 59 7 the the DT cord-291946-kq0rsuxj 59 8 same same JJ cord-291946-kq0rsuxj 59 9 locus locus NN cord-291946-kq0rsuxj 59 10 in in IN cord-291946-kq0rsuxj 59 11 both both DT cord-291946-kq0rsuxj 59 12 mongoose mongoose NN cord-291946-kq0rsuxj 59 13 species specie NNS cord-291946-kq0rsuxj 59 14 shows show VBZ cord-291946-kq0rsuxj 59 15 that that IN cord-291946-kq0rsuxj 59 16 the the DT cord-291946-kq0rsuxj 59 17 insertion insertion NN cord-291946-kq0rsuxj 59 18 occurred occur VBD cord-291946-kq0rsuxj 59 19 before before IN cord-291946-kq0rsuxj 59 20 their -PRON- PRP$ cord-291946-kq0rsuxj 59 21 divergence divergence NN cord-291946-kq0rsuxj 59 22 , , , cord-291946-kq0rsuxj 59 23 approximately approximately RB cord-291946-kq0rsuxj 59 24 8 8 CD cord-291946-kq0rsuxj 59 25 million million CD cord-291946-kq0rsuxj 59 26 years year NNS cord-291946-kq0rsuxj 59 27 ago ago RB cord-291946-kq0rsuxj 59 28 ( ( -LRB- cord-291946-kq0rsuxj 59 29 MYA MYA NNP cord-291946-kq0rsuxj 59 30 ) ) -RRB- cord-291946-kq0rsuxj 59 31 , , , cord-291946-kq0rsuxj 59 32 while while IN cord-291946-kq0rsuxj 59 33 the the DT cord-291946-kq0rsuxj 59 34 absence absence NN cord-291946-kq0rsuxj 59 35 of of IN cord-291946-kq0rsuxj 59 36 EVE EVE NNP cord-291946-kq0rsuxj 59 37 at at IN cord-291946-kq0rsuxj 59 38 this this DT cord-291946-kq0rsuxj 59 39 site site NN cord-291946-kq0rsuxj 59 40 in in IN cord-291946-kq0rsuxj 59 41 the the DT cord-291946-kq0rsuxj 59 42 cat cat NN cord-291946-kq0rsuxj 59 43 species specie NNS cord-291946-kq0rsuxj 59 44 indicates indicate VBZ cord-291946-kq0rsuxj 59 45 that that IN cord-291946-kq0rsuxj 59 46 the the DT cord-291946-kq0rsuxj 59 47 insertion insertion NN cord-291946-kq0rsuxj 59 48 occurred occur VBD cord-291946-kq0rsuxj 59 49 after after IN cord-291946-kq0rsuxj 59 50 36 36 CD cord-291946-kq0rsuxj 59 51 MYA MYA NNP cord-291946-kq0rsuxj 59 52 . . . cord-291946-kq0rsuxj 60 1 Although although IN cord-291946-kq0rsuxj 60 2 not not RB cord-291946-kq0rsuxj 60 3 definitive definitive JJ cord-291946-kq0rsuxj 60 4 , , , cord-291946-kq0rsuxj 60 5 PCR PCR NNP cord-291946-kq0rsuxj 60 6 for for IN cord-291946-kq0rsuxj 60 7 REV REV NNP cord-291946-kq0rsuxj 60 8 in in IN cord-291946-kq0rsuxj 60 9 fossa fossa NN cord-291946-kq0rsuxj 60 10 was be VBD cord-291946-kq0rsuxj 60 11 negative negative JJ cord-291946-kq0rsuxj 60 12 [ [ -LRB- cord-291946-kq0rsuxj 60 13 21 21 CD cord-291946-kq0rsuxj 60 14 ] ] -RRB- cord-291946-kq0rsuxj 60 15 . . . cord-291946-kq0rsuxj 61 1 Here here RB cord-291946-kq0rsuxj 61 2 , , , cord-291946-kq0rsuxj 61 3 a a DT cord-291946-kq0rsuxj 61 4 more more RBR cord-291946-kq0rsuxj 61 5 recent recent JJ cord-291946-kq0rsuxj 61 6 inter inter JJ cord-291946-kq0rsuxj 61 7 - - JJ cord-291946-kq0rsuxj 61 8 class class JJ cord-291946-kq0rsuxj 61 9 transmission transmission NN cord-291946-kq0rsuxj 61 10 from from IN cord-291946-kq0rsuxj 61 11 an an DT cord-291946-kq0rsuxj 61 12 unknown unknown JJ cord-291946-kq0rsuxj 61 13 mammal mammal NN cord-291946-kq0rsuxj 61 14 was be VBD cord-291946-kq0rsuxj 61 15 the the DT cord-291946-kq0rsuxj 61 16 origin origin NN cord-291946-kq0rsuxj 61 17 of of IN cord-291946-kq0rsuxj 61 18 REV REV NNP cord-291946-kq0rsuxj 61 19 in in IN cord-291946-kq0rsuxj 61 20 birds bird NNS cord-291946-kq0rsuxj 61 21 . . . cord-291946-kq0rsuxj 62 1 Image image NN cord-291946-kq0rsuxj 62 2 Credit Credit NNP cord-291946-kq0rsuxj 62 3 : : : cord-291946-kq0rsuxj 62 4 Lucie Lucie NNP cord-291946-kq0rsuxj 62 5 Etienne Etienne NNP cord-291946-kq0rsuxj 62 6 . . . cord-291946-kq0rsuxj 63 1 doi:10.1371 doi:10.1371 NNP cord-291946-kq0rsuxj 64 1 /journal.pbio.1001641.g001 /journal.pbio.1001641.g001 . cord-291946-kq0rsuxj 65 1 In in IN cord-291946-kq0rsuxj 65 2 this this DT cord-291946-kq0rsuxj 65 3 issue issue NN cord-291946-kq0rsuxj 65 4 of of IN cord-291946-kq0rsuxj 65 5 PLOS PLOS NNP cord-291946-kq0rsuxj 65 6 Biology Biology NNP cord-291946-kq0rsuxj 65 7 , , , cord-291946-kq0rsuxj 65 8 Niewiadomska Niewiadomska NNP cord-291946-kq0rsuxj 65 9 and and CC cord-291946-kq0rsuxj 65 10 Gifford Gifford NNP cord-291946-kq0rsuxj 65 11 elucidate elucidate VBP cord-291946-kq0rsuxj 65 12 the the DT cord-291946-kq0rsuxj 65 13 complex complex JJ cord-291946-kq0rsuxj 65 14 evolutionary evolutionary JJ cord-291946-kq0rsuxj 65 15 history history NN cord-291946-kq0rsuxj 65 16 of of IN cord-291946-kq0rsuxj 65 17 REV REV NNP cord-291946-kq0rsuxj 65 18 and and CC cord-291946-kq0rsuxj 65 19 related relate VBN cord-291946-kq0rsuxj 65 20 viral viral JJ cord-291946-kq0rsuxj 65 21 strains strain NNS cord-291946-kq0rsuxj 65 22 by by IN cord-291946-kq0rsuxj 65 23 using use VBG cord-291946-kq0rsuxj 65 24 paleovirology paleovirology NN cord-291946-kq0rsuxj 65 25 and and CC cord-291946-kq0rsuxj 65 26 a a DT cord-291946-kq0rsuxj 65 27 historical historical JJ cord-291946-kq0rsuxj 65 28 review review NN cord-291946-kq0rsuxj 65 29 of of IN cord-291946-kq0rsuxj 65 30 the the DT cord-291946-kq0rsuxj 65 31 literature literature NN cord-291946-kq0rsuxj 65 32 to to TO cord-291946-kq0rsuxj 65 33 infer infer VB cord-291946-kq0rsuxj 65 34 the the DT cord-291946-kq0rsuxj 65 35 viral viral JJ cord-291946-kq0rsuxj 65 36 origin origin NN cord-291946-kq0rsuxj 65 37 , , , cord-291946-kq0rsuxj 65 38 the the DT cord-291946-kq0rsuxj 65 39 successive successive JJ cord-291946-kq0rsuxj 65 40 inter inter JJ cord-291946-kq0rsuxj 65 41 - - JJ cord-291946-kq0rsuxj 65 42 species species JJ cord-291946-kq0rsuxj 65 43 transmissions transmission NNS cord-291946-kq0rsuxj 65 44 , , , cord-291946-kq0rsuxj 65 45 and and CC cord-291946-kq0rsuxj 65 46 the the DT cord-291946-kq0rsuxj 65 47 adaptive adaptive JJ cord-291946-kq0rsuxj 65 48 events event NNS cord-291946-kq0rsuxj 65 49 that that WDT cord-291946-kq0rsuxj 65 50 led lead VBD cord-291946-kq0rsuxj 65 51 to to IN cord-291946-kq0rsuxj 65 52 the the DT cord-291946-kq0rsuxj 65 53 circulation circulation NN cord-291946-kq0rsuxj 65 54 of of IN cord-291946-kq0rsuxj 65 55 REVs rev NNS cord-291946-kq0rsuxj 65 56 in in IN cord-291946-kq0rsuxj 65 57 wild wild JJ cord-291946-kq0rsuxj 65 58 birds bird NNS cord-291946-kq0rsuxj 65 59 [ [ -LRB- cord-291946-kq0rsuxj 65 60 21 21 CD cord-291946-kq0rsuxj 65 61 ] ] -RRB- cord-291946-kq0rsuxj 65 62 . . . cord-291946-kq0rsuxj 66 1 Along along IN cord-291946-kq0rsuxj 66 2 the the DT cord-291946-kq0rsuxj 66 3 way way NN cord-291946-kq0rsuxj 66 4 , , , cord-291946-kq0rsuxj 66 5 the the DT cord-291946-kq0rsuxj 66 6 story story NN cord-291946-kq0rsuxj 66 7 takes take VBZ cord-291946-kq0rsuxj 66 8 us -PRON- PRP cord-291946-kq0rsuxj 66 9 from from IN cord-291946-kq0rsuxj 66 10 a a DT cord-291946-kq0rsuxj 66 11 mongoose mongoose NN cord-291946-kq0rsuxj 66 12 , , , cord-291946-kq0rsuxj 66 13 to to IN cord-291946-kq0rsuxj 66 14 a a DT cord-291946-kq0rsuxj 66 15 pheasant pheasant NN cord-291946-kq0rsuxj 66 16 at at IN cord-291946-kq0rsuxj 66 17 the the DT cord-291946-kq0rsuxj 66 18 Bronx Bronx NNP cord-291946-kq0rsuxj 66 19 Zoo Zoo NNP cord-291946-kq0rsuxj 66 20 , , , cord-291946-kq0rsuxj 66 21 to to IN cord-291946-kq0rsuxj 66 22 a a DT cord-291946-kq0rsuxj 66 23 duck duck NN cord-291946-kq0rsuxj 66 24 model model NN cord-291946-kq0rsuxj 66 25 of of IN cord-291946-kq0rsuxj 66 26 malaria malaria NN cord-291946-kq0rsuxj 66 27 that that WDT cord-291946-kq0rsuxj 66 28 might may MD cord-291946-kq0rsuxj 66 29 have have VB cord-291946-kq0rsuxj 66 30 led lead VBN cord-291946-kq0rsuxj 66 31 to to IN cord-291946-kq0rsuxj 66 32 contamination contamination NN cord-291946-kq0rsuxj 66 33 of of IN cord-291946-kq0rsuxj 66 34 vaccines vaccine NNS cord-291946-kq0rsuxj 66 35 of of IN cord-291946-kq0rsuxj 66 36 large large JJ cord-291946-kq0rsuxj 66 37 DNA dna NN cord-291946-kq0rsuxj 66 38 viruses virus NNS cord-291946-kq0rsuxj 66 39 of of IN cord-291946-kq0rsuxj 66 40 birds bird NNS cord-291946-kq0rsuxj 66 41 , , , cord-291946-kq0rsuxj 66 42 which which WDT cord-291946-kq0rsuxj 66 43 may may MD cord-291946-kq0rsuxj 66 44 have have VB cord-291946-kq0rsuxj 66 45 subsequently subsequently RB cord-291946-kq0rsuxj 66 46 spread spread VB cord-291946-kq0rsuxj 66 47 REV REV NNP cord-291946-kq0rsuxj 66 48 around around IN cord-291946-kq0rsuxj 66 49 the the DT cord-291946-kq0rsuxj 66 50 world world NN cord-291946-kq0rsuxj 66 51 . . . cord-291946-kq0rsuxj 67 1 The the DT cord-291946-kq0rsuxj 67 2 link link NN cord-291946-kq0rsuxj 67 3 between between IN cord-291946-kq0rsuxj 67 4 this this DT cord-291946-kq0rsuxj 67 5 avian avian JJ cord-291946-kq0rsuxj 67 6 retrovirus retrovirus NN cord-291946-kq0rsuxj 67 7 and and CC cord-291946-kq0rsuxj 67 8 endogenous endogenous JJ cord-291946-kq0rsuxj 67 9 elements element NNS cord-291946-kq0rsuxj 67 10 in in IN cord-291946-kq0rsuxj 67 11 mammals mammal NNS cord-291946-kq0rsuxj 67 12 was be VBD cord-291946-kq0rsuxj 67 13 first first RB cord-291946-kq0rsuxj 67 14 documented document VBN cord-291946-kq0rsuxj 67 15 in in IN cord-291946-kq0rsuxj 67 16 a a DT cord-291946-kq0rsuxj 67 17 screen screen NN cord-291946-kq0rsuxj 67 18 of of IN cord-291946-kq0rsuxj 67 19 available available JJ cord-291946-kq0rsuxj 67 20 animal animal NN cord-291946-kq0rsuxj 67 21 genomes genome NNS cord-291946-kq0rsuxj 67 22 in in IN cord-291946-kq0rsuxj 67 23 which which WDT cord-291946-kq0rsuxj 67 24 the the DT cord-291946-kq0rsuxj 67 25 most most RBS cord-291946-kq0rsuxj 67 26 closely closely RB cord-291946-kq0rsuxj 67 27 related related JJ cord-291946-kq0rsuxj 67 28 sequence sequence NN cord-291946-kq0rsuxj 67 29 to to IN cord-291946-kq0rsuxj 67 30 REV REV NNP cord-291946-kq0rsuxj 67 31 was be VBD cord-291946-kq0rsuxj 67 32 from from IN cord-291946-kq0rsuxj 67 33 a a DT cord-291946-kq0rsuxj 67 34 fragment fragment NN cord-291946-kq0rsuxj 67 35 of of IN cord-291946-kq0rsuxj 67 36 the the DT cord-291946-kq0rsuxj 67 37 genome genome NN cord-291946-kq0rsuxj 67 38 of of IN cord-291946-kq0rsuxj 67 39 an an DT cord-291946-kq0rsuxj 67 40 echidna echidna NN cord-291946-kq0rsuxj 67 41 , , , cord-291946-kq0rsuxj 67 42 an an DT cord-291946-kq0rsuxj 67 43 egg egg NN cord-291946-kq0rsuxj 67 44 - - HYPH cord-291946-kq0rsuxj 67 45 laying lay VBG cord-291946-kq0rsuxj 67 46 mammal mammal NN cord-291946-kq0rsuxj 67 47 from from IN cord-291946-kq0rsuxj 67 48 Australasia Australasia NNP cord-291946-kq0rsuxj 67 49 [ [ -LRB- cord-291946-kq0rsuxj 67 50 14 14 CD cord-291946-kq0rsuxj 67 51 ] ] -RRB- cord-291946-kq0rsuxj 67 52 . . . cord-291946-kq0rsuxj 68 1 Niewiadomska Niewiadomska NNP cord-291946-kq0rsuxj 68 2 and and CC cord-291946-kq0rsuxj 68 3 Gifford Gifford NNP cord-291946-kq0rsuxj 68 4 were be VBD cord-291946-kq0rsuxj 68 5 characterizing characterize VBG cord-291946-kq0rsuxj 68 6 the the DT cord-291946-kq0rsuxj 68 7 diversity diversity NN cord-291946-kq0rsuxj 68 8 of of IN cord-291946-kq0rsuxj 68 9 endogenous endogenous JJ cord-291946-kq0rsuxj 68 10 retroviral retroviral JJ cord-291946-kq0rsuxj 68 11 elements element NNS cord-291946-kq0rsuxj 68 12 in in IN cord-291946-kq0rsuxj 68 13 Malagasy Malagasy NNP cord-291946-kq0rsuxj 68 14 carnivores carnivore NNS cord-291946-kq0rsuxj 68 15 using use VBG cord-291946-kq0rsuxj 68 16 previously previously RB cord-291946-kq0rsuxj 68 17 frozen frozen JJ cord-291946-kq0rsuxj 68 18 tissue tissue NN cord-291946-kq0rsuxj 68 19 samples sample NNS cord-291946-kq0rsuxj 68 20 , , , cord-291946-kq0rsuxj 68 21 and and CC cord-291946-kq0rsuxj 68 22 fortuitously fortuitously RB cord-291946-kq0rsuxj 68 23 happened happen VBD cord-291946-kq0rsuxj 68 24 upon upon IN cord-291946-kq0rsuxj 68 25 REV REV NNP cord-291946-kq0rsuxj 68 26 - - HYPH cord-291946-kq0rsuxj 68 27 like like JJ cord-291946-kq0rsuxj 68 28 sequences sequence NNS cord-291946-kq0rsuxj 68 29 in in IN cord-291946-kq0rsuxj 68 30 the the DT cord-291946-kq0rsuxj 68 31 genome genome NN cord-291946-kq0rsuxj 68 32 of of IN cord-291946-kq0rsuxj 68 33 the the DT cord-291946-kq0rsuxj 68 34 ring ring NN cord-291946-kq0rsuxj 68 35 - - HYPH cord-291946-kq0rsuxj 68 36 tailed tailed JJ cord-291946-kq0rsuxj 68 37 mongoose mongoose NN cord-291946-kq0rsuxj 68 38 and and CC cord-291946-kq0rsuxj 68 39 the the DT cord-291946-kq0rsuxj 68 40 narrow narrow JJ cord-291946-kq0rsuxj 68 41 - - HYPH cord-291946-kq0rsuxj 68 42 striped striped JJ cord-291946-kq0rsuxj 68 43 mongoose mongoose NN cord-291946-kq0rsuxj 68 44 [ [ -LRB- cord-291946-kq0rsuxj 68 45 21 21 CD cord-291946-kq0rsuxj 68 46 ] ] -RRB- cord-291946-kq0rsuxj 68 47 . . . cord-291946-kq0rsuxj 69 1 Additional additional JJ cord-291946-kq0rsuxj 69 2 DNA dna NN cord-291946-kq0rsuxj 69 3 sequencing sequencing NN cord-291946-kq0rsuxj 69 4 identified identify VBN cord-291946-kq0rsuxj 69 5 viral viral JJ cord-291946-kq0rsuxj 69 6 sequences sequence NNS cord-291946-kq0rsuxj 69 7 that that WDT cord-291946-kq0rsuxj 69 8 were be VBD cord-291946-kq0rsuxj 69 9 similar similar JJ cord-291946-kq0rsuxj 69 10 to to IN cord-291946-kq0rsuxj 69 11 REV REV NNP cord-291946-kq0rsuxj 69 12 across across IN cord-291946-kq0rsuxj 69 13 the the DT cord-291946-kq0rsuxj 69 14 entire entire JJ cord-291946-kq0rsuxj 69 15 viral viral JJ cord-291946-kq0rsuxj 69 16 genome genome NN cord-291946-kq0rsuxj 69 17 , , , cord-291946-kq0rsuxj 69 18 including include VBG cord-291946-kq0rsuxj 69 19 the the DT cord-291946-kq0rsuxj 69 20 same same JJ cord-291946-kq0rsuxj 69 21 recombination recombination NN cord-291946-kq0rsuxj 69 22 breakpoint breakpoint NN cord-291946-kq0rsuxj 69 23 found find VBN cord-291946-kq0rsuxj 69 24 in in IN cord-291946-kq0rsuxj 69 25 modern modern JJ cord-291946-kq0rsuxj 69 26 REV REV NNP cord-291946-kq0rsuxj 69 27 . . . cord-291946-kq0rsuxj 70 1 This this DT cord-291946-kq0rsuxj 70 2 crucial crucial JJ cord-291946-kq0rsuxj 70 3 finding finding NN cord-291946-kq0rsuxj 70 4 showed show VBD cord-291946-kq0rsuxj 70 5 definitively definitively RB cord-291946-kq0rsuxj 70 6 that that IN cord-291946-kq0rsuxj 70 7 the the DT cord-291946-kq0rsuxj 70 8 endogenous endogenous JJ cord-291946-kq0rsuxj 70 9 retrovirus retrovirus NN cord-291946-kq0rsuxj 70 10 from from IN cord-291946-kq0rsuxj 70 11 mammals mammal NNS cord-291946-kq0rsuxj 70 12 and and CC cord-291946-kq0rsuxj 70 13 the the DT cord-291946-kq0rsuxj 70 14 currently currently RB cord-291946-kq0rsuxj 70 15 circulating circulate VBG cord-291946-kq0rsuxj 70 16 avian avian JJ cord-291946-kq0rsuxj 70 17 exogenous exogenous JJ cord-291946-kq0rsuxj 70 18 REVs rev NNS cord-291946-kq0rsuxj 70 19 share share VBP cord-291946-kq0rsuxj 70 20 a a DT cord-291946-kq0rsuxj 70 21 common common JJ cord-291946-kq0rsuxj 70 22 ancestor ancestor NN cord-291946-kq0rsuxj 70 23 . . . cord-291946-kq0rsuxj 71 1 To to TO cord-291946-kq0rsuxj 71 2 estimate estimate VB cord-291946-kq0rsuxj 71 3 the the DT cord-291946-kq0rsuxj 71 4 age age NN cord-291946-kq0rsuxj 71 5 of of IN cord-291946-kq0rsuxj 71 6 this this DT cord-291946-kq0rsuxj 71 7 ancient ancient JJ cord-291946-kq0rsuxj 71 8 retroviral retroviral NN cord-291946-kq0rsuxj 71 9 lineage lineage NN cord-291946-kq0rsuxj 71 10 , , , cord-291946-kq0rsuxj 71 11 the the DT cord-291946-kq0rsuxj 71 12 authors author NNS cord-291946-kq0rsuxj 71 13 showed show VBD cord-291946-kq0rsuxj 71 14 that that IN cord-291946-kq0rsuxj 71 15 the the DT cord-291946-kq0rsuxj 71 16 flanking flank VBG cord-291946-kq0rsuxj 71 17 regions region NNS cord-291946-kq0rsuxj 71 18 of of IN cord-291946-kq0rsuxj 71 19 the the DT cord-291946-kq0rsuxj 71 20 newly newly RB cord-291946-kq0rsuxj 71 21 characterized characterize VBN cord-291946-kq0rsuxj 71 22 EVEs eve NNS cord-291946-kq0rsuxj 71 23 were be VBD cord-291946-kq0rsuxj 71 24 common common JJ cord-291946-kq0rsuxj 71 25 to to IN cord-291946-kq0rsuxj 71 26 the the DT cord-291946-kq0rsuxj 71 27 two two CD cord-291946-kq0rsuxj 71 28 mongoose mongoose NN cord-291946-kq0rsuxj 71 29 species specie NNS cord-291946-kq0rsuxj 71 30 [ [ -LRB- cord-291946-kq0rsuxj 71 31 21 21 CD cord-291946-kq0rsuxj 71 32 ] ] -RRB- cord-291946-kq0rsuxj 71 33 , , , cord-291946-kq0rsuxj 71 34 thus thus RB cord-291946-kq0rsuxj 71 35 showing show VBG cord-291946-kq0rsuxj 71 36 the the DT cord-291946-kq0rsuxj 71 37 REV REV NNP cord-291946-kq0rsuxj 71 38 - - HYPH cord-291946-kq0rsuxj 71 39 like like JJ cord-291946-kq0rsuxj 71 40 retrovirus retrovirus NN cord-291946-kq0rsuxj 71 41 entered enter VBD cord-291946-kq0rsuxj 71 42 the the DT cord-291946-kq0rsuxj 71 43 germline germline NN cord-291946-kq0rsuxj 71 44 and and CC cord-291946-kq0rsuxj 71 45 reached reach VBN cord-291946-kq0rsuxj 71 46 fixation fixation NN cord-291946-kq0rsuxj 71 47 before before IN cord-291946-kq0rsuxj 71 48 the the DT cord-291946-kq0rsuxj 71 49 split split NN cord-291946-kq0rsuxj 71 50 between between IN cord-291946-kq0rsuxj 71 51 these these DT cord-291946-kq0rsuxj 71 52 two two CD cord-291946-kq0rsuxj 71 53 species specie NNS cord-291946-kq0rsuxj 71 54 during during IN cord-291946-kq0rsuxj 71 55 the the DT cord-291946-kq0rsuxj 71 56 Miocene miocene JJ cord-291946-kq0rsuxj 71 57 period period NN cord-291946-kq0rsuxj 71 58 ( ( -LRB- cord-291946-kq0rsuxj 71 59 Figure figure NN cord-291946-kq0rsuxj 71 60 1 1 CD cord-291946-kq0rsuxj 71 61 ) ) -RRB- cord-291946-kq0rsuxj 71 62 . . . cord-291946-kq0rsuxj 72 1 Therefore therefore RB cord-291946-kq0rsuxj 72 2 , , , cord-291946-kq0rsuxj 72 3 an an DT cord-291946-kq0rsuxj 72 4 exogenous exogenous JJ cord-291946-kq0rsuxj 72 5 recombinant recombinant JJ cord-291946-kq0rsuxj 72 6 REV REV NNP cord-291946-kq0rsuxj 72 7 - - HYPH cord-291946-kq0rsuxj 72 8 like like JJ cord-291946-kq0rsuxj 72 9 virus virus NN cord-291946-kq0rsuxj 72 10 was be VBD cord-291946-kq0rsuxj 72 11 circulating circulate VBG cord-291946-kq0rsuxj 72 12 in in IN cord-291946-kq0rsuxj 72 13 mammals mammal NNS cord-291946-kq0rsuxj 72 14 more more JJR cord-291946-kq0rsuxj 72 15 than than IN cord-291946-kq0rsuxj 72 16 8 8 CD cord-291946-kq0rsuxj 72 17 million million CD cord-291946-kq0rsuxj 72 18 years year NNS cord-291946-kq0rsuxj 72 19 ago ago RB cord-291946-kq0rsuxj 72 20 . . . cord-291946-kq0rsuxj 73 1 How how WRB cord-291946-kq0rsuxj 73 2 then then RB cord-291946-kq0rsuxj 73 3 did do VBD cord-291946-kq0rsuxj 73 4 this this DT cord-291946-kq0rsuxj 73 5 mammalian mammalian JJ cord-291946-kq0rsuxj 73 6 retrovirus retrovirus NN cord-291946-kq0rsuxj 73 7 get get VBP cord-291946-kq0rsuxj 73 8 into into IN cord-291946-kq0rsuxj 73 9 birds bird NNS cord-291946-kq0rsuxj 73 10 ? ? . cord-291946-kq0rsuxj 74 1 From from IN cord-291946-kq0rsuxj 74 2 here here RB cord-291946-kq0rsuxj 74 3 the the DT cord-291946-kq0rsuxj 74 4 story story NN cord-291946-kq0rsuxj 74 5 gets get VBZ cord-291946-kq0rsuxj 74 6 spectacular spectacular JJ cord-291946-kq0rsuxj 74 7 and and CC cord-291946-kq0rsuxj 74 8 strange strange JJ cord-291946-kq0rsuxj 74 9 ( ( -LRB- cord-291946-kq0rsuxj 74 10 yet yet CC cord-291946-kq0rsuxj 74 11 still still RB cord-291946-kq0rsuxj 74 12 very very RB cord-291946-kq0rsuxj 74 13 plausible plausible JJ cord-291946-kq0rsuxj 74 14 ) ) -RRB- cord-291946-kq0rsuxj 74 15 . . . cord-291946-kq0rsuxj 75 1 In in IN cord-291946-kq0rsuxj 75 2 the the DT cord-291946-kq0rsuxj 75 3 1930s 1930 NNS cord-291946-kq0rsuxj 75 4 , , , cord-291946-kq0rsuxj 75 5 the the DT cord-291946-kq0rsuxj 75 6 need need NN cord-291946-kq0rsuxj 75 7 for for IN cord-291946-kq0rsuxj 75 8 an an DT cord-291946-kq0rsuxj 75 9 experimental experimental JJ cord-291946-kq0rsuxj 75 10 model model NN cord-291946-kq0rsuxj 75 11 system system NN cord-291946-kq0rsuxj 75 12 for for IN cord-291946-kq0rsuxj 75 13 malaria malaria NN cord-291946-kq0rsuxj 75 14 research research NN cord-291946-kq0rsuxj 75 15 led lead VBD cord-291946-kq0rsuxj 75 16 Lowell Lowell NNP cord-291946-kq0rsuxj 75 17 Coggeshall Coggeshall NNP cord-291946-kq0rsuxj 75 18 to to TO cord-291946-kq0rsuxj 75 19 isolate isolate VB cord-291946-kq0rsuxj 75 20 Plasmodium plasmodium NN cord-291946-kq0rsuxj 75 21 parasites parasite NNS cord-291946-kq0rsuxj 75 22 from from IN cord-291946-kq0rsuxj 75 23 a a DT cord-291946-kq0rsuxj 75 24 pheasant pheasant NN cord-291946-kq0rsuxj 75 25 , , , cord-291946-kq0rsuxj 75 26 originally originally RB cord-291946-kq0rsuxj 75 27 from from IN cord-291946-kq0rsuxj 75 28 Borneo Borneo NNP cord-291946-kq0rsuxj 75 29 , , , cord-291946-kq0rsuxj 75 30 that that WDT cord-291946-kq0rsuxj 75 31 was be VBD cord-291946-kq0rsuxj 75 32 housed house VBN cord-291946-kq0rsuxj 75 33 at at IN cord-291946-kq0rsuxj 75 34 the the DT cord-291946-kq0rsuxj 75 35 Bronx Bronx NNP cord-291946-kq0rsuxj 75 36 Zoo Zoo NNP cord-291946-kq0rsuxj 75 37 . . . cord-291946-kq0rsuxj 76 1 For for IN cord-291946-kq0rsuxj 76 2 experimental experimental JJ cord-291946-kq0rsuxj 76 3 vaccine vaccine NN cord-291946-kq0rsuxj 76 4 and and CC cord-291946-kq0rsuxj 76 5 drug drug NN cord-291946-kq0rsuxj 76 6 research research NN cord-291946-kq0rsuxj 76 7 purposes purpose NNS cord-291946-kq0rsuxj 76 8 , , , cord-291946-kq0rsuxj 76 9 the the DT cord-291946-kq0rsuxj 76 10 Plasmodium Plasmodium NNP cord-291946-kq0rsuxj 76 11 stock stock NN cord-291946-kq0rsuxj 76 12 was be VBD cord-291946-kq0rsuxj 76 13 passaged passage VBN cord-291946-kq0rsuxj 76 14 over over IN cord-291946-kq0rsuxj 76 15 time time NN cord-291946-kq0rsuxj 76 16 in in IN cord-291946-kq0rsuxj 76 17 poultry poultry NN cord-291946-kq0rsuxj 76 18 until until IN cord-291946-kq0rsuxj 76 19 the the DT cord-291946-kq0rsuxj 76 20 1980s 1980s CD cord-291946-kq0rsuxj 76 21 and and CC cord-291946-kq0rsuxj 76 22 was be VBD cord-291946-kq0rsuxj 76 23 distributed distribute VBN cord-291946-kq0rsuxj 76 24 to to IN cord-291946-kq0rsuxj 76 25 many many JJ cord-291946-kq0rsuxj 76 26 US US NNP cord-291946-kq0rsuxj 76 27 laboratories laboratory NNS cord-291946-kq0rsuxj 76 28 . . . cord-291946-kq0rsuxj 77 1 However however RB cord-291946-kq0rsuxj 77 2 , , , cord-291946-kq0rsuxj 77 3 the the DT cord-291946-kq0rsuxj 77 4 culture culture NN cord-291946-kq0rsuxj 77 5 of of IN cord-291946-kq0rsuxj 77 6 Plasmodium Plasmodium NNP cord-291946-kq0rsuxj 77 7 lophurae lophurae NNP cord-291946-kq0rsuxj 77 8 was be VBD cord-291946-kq0rsuxj 77 9 contaminated contaminate VBN cord-291946-kq0rsuxj 77 10 with with IN cord-291946-kq0rsuxj 77 11 retroviruses retrovirus NNS cord-291946-kq0rsuxj 77 12 from from IN cord-291946-kq0rsuxj 77 13 the the DT cord-291946-kq0rsuxj 77 14 REV REV NNP cord-291946-kq0rsuxj 77 15 lineages lineage NNS cord-291946-kq0rsuxj 77 16 ( ( -LRB- cord-291946-kq0rsuxj 77 17 contamination contamination NN cord-291946-kq0rsuxj 77 18 may may MD cord-291946-kq0rsuxj 77 19 have have VB cord-291946-kq0rsuxj 77 20 existed exist VBN cord-291946-kq0rsuxj 77 21 in in IN cord-291946-kq0rsuxj 77 22 the the DT cord-291946-kq0rsuxj 77 23 pheasant pheasant NN cord-291946-kq0rsuxj 77 24 , , , cord-291946-kq0rsuxj 77 25 or or CC cord-291946-kq0rsuxj 77 26 might may MD cord-291946-kq0rsuxj 77 27 have have VB cord-291946-kq0rsuxj 77 28 been be VBN cord-291946-kq0rsuxj 77 29 acquired acquire VBN cord-291946-kq0rsuxj 77 30 during during IN cord-291946-kq0rsuxj 77 31 passage passage NN cord-291946-kq0rsuxj 77 32 ) ) -RRB- cord-291946-kq0rsuxj 77 33 . . . cord-291946-kq0rsuxj 78 1 The the DT cord-291946-kq0rsuxj 78 2 authors author NNS cord-291946-kq0rsuxj 78 3 depict depict VBP cord-291946-kq0rsuxj 78 4 a a DT cord-291946-kq0rsuxj 78 5 compelling compelling JJ cord-291946-kq0rsuxj 78 6 scenario scenario NN cord-291946-kq0rsuxj 78 7 in in IN cord-291946-kq0rsuxj 78 8 which which WDT cord-291946-kq0rsuxj 78 9 the the DT cord-291946-kq0rsuxj 78 10 zoological zoological JJ cord-291946-kq0rsuxj 78 11 park park NN cord-291946-kq0rsuxj 78 12 , , , cord-291946-kq0rsuxj 78 13 an an DT cord-291946-kq0rsuxj 78 14 environment environment NN cord-291946-kq0rsuxj 78 15 in in IN cord-291946-kq0rsuxj 78 16 which which WDT cord-291946-kq0rsuxj 78 17 exotic exotic JJ cord-291946-kq0rsuxj 78 18 animal animal NN cord-291946-kq0rsuxj 78 19 species specie NNS cord-291946-kq0rsuxj 78 20 from from IN cord-291946-kq0rsuxj 78 21 diverse diverse JJ cord-291946-kq0rsuxj 78 22 lineages lineage NNS cord-291946-kq0rsuxj 78 23 are be VBP cord-291946-kq0rsuxj 78 24 brought bring VBN cord-291946-kq0rsuxj 78 25 together together RB cord-291946-kq0rsuxj 78 26 in in IN cord-291946-kq0rsuxj 78 27 unusually unusually RB cord-291946-kq0rsuxj 78 28 close close JJ cord-291946-kq0rsuxj 78 29 proximity proximity NN cord-291946-kq0rsuxj 78 30 , , , cord-291946-kq0rsuxj 78 31 could could MD cord-291946-kq0rsuxj 78 32 have have VB cord-291946-kq0rsuxj 78 33 favored favor VBN cord-291946-kq0rsuxj 78 34 the the DT cord-291946-kq0rsuxj 78 35 inter inter JJ cord-291946-kq0rsuxj 78 36 - - JJ cord-291946-kq0rsuxj 78 37 class class JJ cord-291946-kq0rsuxj 78 38 transmission transmission NN cord-291946-kq0rsuxj 78 39 of of IN cord-291946-kq0rsuxj 78 40 REVs rev NNS cord-291946-kq0rsuxj 78 41 from from IN cord-291946-kq0rsuxj 78 42 mammals mammal NNS cord-291946-kq0rsuxj 78 43 to to IN cord-291946-kq0rsuxj 78 44 the the DT cord-291946-kq0rsuxj 78 45 pheasant pheasant NN cord-291946-kq0rsuxj 78 46 from from IN cord-291946-kq0rsuxj 78 47 which which WDT cord-291946-kq0rsuxj 78 48 Plasmodium plasmodium NN cord-291946-kq0rsuxj 78 49 was be VBD cord-291946-kq0rsuxj 78 50 isolated isolate VBN cord-291946-kq0rsuxj 78 51 . . . cord-291946-kq0rsuxj 79 1 However however RB cord-291946-kq0rsuxj 79 2 , , , cord-291946-kq0rsuxj 79 3 as as IN cord-291946-kq0rsuxj 79 4 inter inter JJ cord-291946-kq0rsuxj 79 5 - - JJ cord-291946-kq0rsuxj 79 6 class class JJ cord-291946-kq0rsuxj 79 7 transmissions transmission NNS cord-291946-kq0rsuxj 79 8 often often RB cord-291946-kq0rsuxj 79 9 result result VBP cord-291946-kq0rsuxj 79 10 in in IN cord-291946-kq0rsuxj 79 11 deadend deadend JJ cord-291946-kq0rsuxj 79 12 infections infection NNS cord-291946-kq0rsuxj 79 13 , , , cord-291946-kq0rsuxj 79 14 the the DT cord-291946-kq0rsuxj 79 15 authors author NNS cord-291946-kq0rsuxj 79 16 surmise surmise VBP cord-291946-kq0rsuxj 79 17 that that IN cord-291946-kq0rsuxj 79 18 serial serial JJ cord-291946-kq0rsuxj 79 19 passages passage NNS cord-291946-kq0rsuxj 79 20 of of IN cord-291946-kq0rsuxj 79 21 the the DT cord-291946-kq0rsuxj 79 22 retrovirus retrovirus NN cord-291946-kq0rsuxj 79 23 - - HYPH cord-291946-kq0rsuxj 79 24 containing contain VBG cord-291946-kq0rsuxj 79 25 Plasmodium Plasmodium NNP cord-291946-kq0rsuxj 79 26 stock stock NN cord-291946-kq0rsuxj 79 27 in in IN cord-291946-kq0rsuxj 79 28 poultry poultry NN cord-291946-kq0rsuxj 79 29 favored favor VBD cord-291946-kq0rsuxj 79 30 the the DT cord-291946-kq0rsuxj 79 31 adaptation adaptation NN cord-291946-kq0rsuxj 79 32 of of IN cord-291946-kq0rsuxj 79 33 the the DT cord-291946-kq0rsuxj 79 34 mammalian mammalian JJ cord-291946-kq0rsuxj 79 35 virus virus NN cord-291946-kq0rsuxj 79 36 to to TO cord-291946-kq0rsuxj 79 37 bird bird NN cord-291946-kq0rsuxj 79 38 hosts host NNS cord-291946-kq0rsuxj 79 39 . . . cord-291946-kq0rsuxj 80 1 Sometime sometime RB cord-291946-kq0rsuxj 80 2 along along IN cord-291946-kq0rsuxj 80 3 the the DT cord-291946-kq0rsuxj 80 4 way way NN cord-291946-kq0rsuxj 80 5 , , , cord-291946-kq0rsuxj 80 6 the the DT cord-291946-kq0rsuxj 80 7 REV REV NNP cord-291946-kq0rsuxj 80 8 virus virus NN cord-291946-kq0rsuxj 80 9 integrated integrate VBN cord-291946-kq0rsuxj 80 10 into into IN cord-291946-kq0rsuxj 80 11 two two CD cord-291946-kq0rsuxj 80 12 large large JJ cord-291946-kq0rsuxj 80 13 DNA dna NN cord-291946-kq0rsuxj 80 14 viruses virus NNS cord-291946-kq0rsuxj 80 15 : : : cord-291946-kq0rsuxj 80 16 a a DT cord-291946-kq0rsuxj 80 17 poxvirus poxvirus NNP cord-291946-kq0rsuxj 80 18 ( ( -LRB- cord-291946-kq0rsuxj 80 19 FWPV FWPV NNP cord-291946-kq0rsuxj 80 20 ) ) -RRB- cord-291946-kq0rsuxj 80 21 that that WDT cord-291946-kq0rsuxj 80 22 contained contain VBD cord-291946-kq0rsuxj 80 23 a a DT cord-291946-kq0rsuxj 80 24 full full JJ cord-291946-kq0rsuxj 80 25 - - HYPH cord-291946-kq0rsuxj 80 26 length length NN cord-291946-kq0rsuxj 80 27 insertion insertion NN cord-291946-kq0rsuxj 80 28 of of IN cord-291946-kq0rsuxj 80 29 REV REV NNP cord-291946-kq0rsuxj 80 30 and and CC cord-291946-kq0rsuxj 80 31 a a DT cord-291946-kq0rsuxj 80 32 herpesvirus herpesvirus NN cord-291946-kq0rsuxj 80 33 ( ( -LRB- cord-291946-kq0rsuxj 80 34 GHV-2 GHV-2 NNP cord-291946-kq0rsuxj 80 35 ) ) -RRB- cord-291946-kq0rsuxj 80 36 containing contain VBG cord-291946-kq0rsuxj 80 37 only only RB cord-291946-kq0rsuxj 80 38 a a DT cord-291946-kq0rsuxj 80 39 fragment fragment NN cord-291946-kq0rsuxj 80 40 of of IN cord-291946-kq0rsuxj 80 41 REV REV NNP cord-291946-kq0rsuxj 80 42 [ [ -LRB- cord-291946-kq0rsuxj 80 43 19 19 CD cord-291946-kq0rsuxj 80 44 , , , cord-291946-kq0rsuxj 80 45 20 20 CD cord-291946-kq0rsuxj 80 46 ] ] -RRB- cord-291946-kq0rsuxj 80 47 . . . cord-291946-kq0rsuxj 81 1 Because because IN cord-291946-kq0rsuxj 81 2 live live JJ cord-291946-kq0rsuxj 81 3 attenuated attenuated JJ cord-291946-kq0rsuxj 81 4 FWPV FWPV NNP cord-291946-kq0rsuxj 81 5 vaccines vaccine NNS cord-291946-kq0rsuxj 81 6 harboring harbor VBG cord-291946-kq0rsuxj 81 7 replicative replicative JJ cord-291946-kq0rsuxj 81 8 competent competent JJ cord-291946-kq0rsuxj 81 9 REVs rev NNS cord-291946-kq0rsuxj 81 10 were be VBD cord-291946-kq0rsuxj 81 11 used use VBN cord-291946-kq0rsuxj 81 12 in in IN cord-291946-kq0rsuxj 81 13 vaccination vaccination NN cord-291946-kq0rsuxj 81 14 campaigns campaign NNS cord-291946-kq0rsuxj 81 15 of of IN cord-291946-kq0rsuxj 81 16 poultry poultry NN cord-291946-kq0rsuxj 81 17 , , , cord-291946-kq0rsuxj 81 18 it -PRON- PRP cord-291946-kq0rsuxj 81 19 may may MD cord-291946-kq0rsuxj 81 20 have have VB cord-291946-kq0rsuxj 81 21 further further RB cord-291946-kq0rsuxj 81 22 played play VBN cord-291946-kq0rsuxj 81 23 a a DT cord-291946-kq0rsuxj 81 24 role role NN cord-291946-kq0rsuxj 81 25 in in IN cord-291946-kq0rsuxj 81 26 the the DT cord-291946-kq0rsuxj 81 27 spread spread NN cord-291946-kq0rsuxj 81 28 of of IN cord-291946-kq0rsuxj 81 29 REVs rev NNS cord-291946-kq0rsuxj 81 30 into into IN cord-291946-kq0rsuxj 81 31 wild wild JJ cord-291946-kq0rsuxj 81 32 birds bird NNS cord-291946-kq0rsuxj 81 33 around around IN cord-291946-kq0rsuxj 81 34 the the DT cord-291946-kq0rsuxj 81 35 world world NN cord-291946-kq0rsuxj 81 36 [ [ -LRB- cord-291946-kq0rsuxj 81 37 21 21 CD cord-291946-kq0rsuxj 81 38 ] ] -RRB- cord-291946-kq0rsuxj 81 39 . . . cord-291946-kq0rsuxj 82 1 Thus thus RB cord-291946-kq0rsuxj 82 2 , , , cord-291946-kq0rsuxj 82 3 REV REV NNP cord-291946-kq0rsuxj 82 4 is be VBZ cord-291946-kq0rsuxj 82 5 now now RB cord-291946-kq0rsuxj 82 6 a a DT cord-291946-kq0rsuxj 82 7 bird bird NN cord-291946-kq0rsuxj 82 8 virus virus NN cord-291946-kq0rsuxj 82 9 that that WDT cord-291946-kq0rsuxj 82 10 was be VBD cord-291946-kq0rsuxj 82 11 once once RB cord-291946-kq0rsuxj 82 12 an an DT cord-291946-kq0rsuxj 82 13 ancient ancient JJ cord-291946-kq0rsuxj 82 14 mammalian mammalian JJ cord-291946-kq0rsuxj 82 15 virus virus NN cord-291946-kq0rsuxj 82 16 ( ( -LRB- cord-291946-kq0rsuxj 82 17 Box Box NNP cord-291946-kq0rsuxj 82 18 1 1 CD cord-291946-kq0rsuxj 82 19 ) ) -RRB- cord-291946-kq0rsuxj 82 20 . . . cord-291946-kq0rsuxj 83 1 Further further JJ cord-291946-kq0rsuxj 83 2 efforts effort NNS cord-291946-kq0rsuxj 83 3 are be VBP cord-291946-kq0rsuxj 83 4 needed need VBN cord-291946-kq0rsuxj 83 5 to to TO cord-291946-kq0rsuxj 83 6 determine determine VB cord-291946-kq0rsuxj 83 7 if if IN cord-291946-kq0rsuxj 83 8 REV REV NNP cord-291946-kq0rsuxj 83 9 still still RB cord-291946-kq0rsuxj 83 10 has have VBZ cord-291946-kq0rsuxj 83 11 a a DT cord-291946-kq0rsuxj 83 12 modern modern JJ cord-291946-kq0rsuxj 83 13 mammalian mammalian JJ cord-291946-kq0rsuxj 83 14 host host NN cord-291946-kq0rsuxj 83 15 ; ; : cord-291946-kq0rsuxj 83 16 the the DT cord-291946-kq0rsuxj 83 17 authors author NNS cord-291946-kq0rsuxj 83 18 of of IN cord-291946-kq0rsuxj 83 19 this this DT cord-291946-kq0rsuxj 83 20 study study NN cord-291946-kq0rsuxj 83 21 speculate speculate VBP cord-291946-kq0rsuxj 83 22 it -PRON- PRP cord-291946-kq0rsuxj 83 23 could could MD cord-291946-kq0rsuxj 83 24 be be VB cord-291946-kq0rsuxj 83 25 a a DT cord-291946-kq0rsuxj 83 26 bat bat NN cord-291946-kq0rsuxj 83 27 species specie NNS cord-291946-kq0rsuxj 83 28 [ [ -LRB- cord-291946-kq0rsuxj 83 29 21 21 CD cord-291946-kq0rsuxj 83 30 ] ] -RRB- cord-291946-kq0rsuxj 83 31 . . . cord-291946-kq0rsuxj 84 1 Indeed indeed RB cord-291946-kq0rsuxj 84 2 , , , cord-291946-kq0rsuxj 84 3 the the DT cord-291946-kq0rsuxj 84 4 reservoir reservoir NN cord-291946-kq0rsuxj 84 5 of of IN cord-291946-kq0rsuxj 84 6 viruses virus NNS cord-291946-kq0rsuxj 84 7 is be VBZ cord-291946-kq0rsuxj 84 8 vast vast JJ cord-291946-kq0rsuxj 84 9 , , , cord-291946-kq0rsuxj 84 10 and and CC cord-291946-kq0rsuxj 84 11 recent recent JJ cord-291946-kq0rsuxj 84 12 field field NN cord-291946-kq0rsuxj 84 13 studies study NNS cord-291946-kq0rsuxj 84 14 and and CC cord-291946-kq0rsuxj 84 15 metagenomic metagenomic NNP cord-291946-kq0rsuxj 84 16 screens screen NNS cord-291946-kq0rsuxj 84 17 are be VBP cord-291946-kq0rsuxj 84 18 finding find VBG cord-291946-kq0rsuxj 84 19 relatives relative NNS cord-291946-kq0rsuxj 84 20 of of IN cord-291946-kq0rsuxj 84 21 human human JJ cord-291946-kq0rsuxj 84 22 and and CC cord-291946-kq0rsuxj 84 23 domestic domestic JJ cord-291946-kq0rsuxj 84 24 animal animal NN cord-291946-kq0rsuxj 84 25 viral viral JJ cord-291946-kq0rsuxj 84 26 pathogens pathogen NNS cord-291946-kq0rsuxj 84 27 in in IN cord-291946-kq0rsuxj 84 28 unexpected unexpected JJ cord-291946-kq0rsuxj 84 29 places place NNS cord-291946-kq0rsuxj 84 30 ( ( -LRB- cord-291946-kq0rsuxj 84 31 for for IN cord-291946-kq0rsuxj 84 32 example example NN cord-291946-kq0rsuxj 84 33 , , , cord-291946-kq0rsuxj 84 34 [ [ -LRB- cord-291946-kq0rsuxj 84 35 22 22 CD cord-291946-kq0rsuxj 84 36 ] ] -RRB- cord-291946-kq0rsuxj 84 37 ) ) -RRB- cord-291946-kq0rsuxj 84 38 . . . cord-291946-kq0rsuxj 85 1 Moreover moreover RB cord-291946-kq0rsuxj 85 2 , , , cord-291946-kq0rsuxj 85 3 it -PRON- PRP cord-291946-kq0rsuxj 85 4 will will MD cord-291946-kq0rsuxj 85 5 be be VB cord-291946-kq0rsuxj 85 6 important important JJ cord-291946-kq0rsuxj 85 7 to to TO cord-291946-kq0rsuxj 85 8 determine determine VB cord-291946-kq0rsuxj 85 9 if if IN cord-291946-kq0rsuxj 85 10 the the DT cord-291946-kq0rsuxj 85 11 ancient ancient JJ cord-291946-kq0rsuxj 85 12 exogenous exogenous JJ cord-291946-kq0rsuxj 85 13 REV REV NNP cord-291946-kq0rsuxj 85 14 had have VBD cord-291946-kq0rsuxj 85 15 a a DT cord-291946-kq0rsuxj 85 16 wider wide JJR cord-291946-kq0rsuxj 85 17 reservoir reservoir NN cord-291946-kq0rsuxj 85 18 by by IN cord-291946-kq0rsuxj 85 19 investigating investigate VBG cord-291946-kq0rsuxj 85 20 more more JJR cord-291946-kq0rsuxj 85 21 animal animal NN cord-291946-kq0rsuxj 85 22 genomes genome NNS cord-291946-kq0rsuxj 85 23 ( ( -LRB- cord-291946-kq0rsuxj 85 24 Figure figure NN cord-291946-kq0rsuxj 85 25 1 1 CD cord-291946-kq0rsuxj 85 26 ) ) -RRB- cord-291946-kq0rsuxj 85 27 . . . cord-291946-kq0rsuxj 86 1 Importantly importantly RB cord-291946-kq0rsuxj 86 2 , , , cord-291946-kq0rsuxj 86 3 the the DT cord-291946-kq0rsuxj 86 4 increasing increase VBG cord-291946-kq0rsuxj 86 5 number number NN cord-291946-kq0rsuxj 86 6 of of IN cord-291946-kq0rsuxj 86 7 full full JJ cord-291946-kq0rsuxj 86 8 - - HYPH cord-291946-kq0rsuxj 86 9 length length NN cord-291946-kq0rsuxj 86 10 genome genome NN cord-291946-kq0rsuxj 86 11 data datum NNS cord-291946-kq0rsuxj 86 12 obtained obtain VBN cord-291946-kq0rsuxj 86 13 by by IN cord-291946-kq0rsuxj 86 14 next next JJ cord-291946-kq0rsuxj 86 15 - - HYPH cord-291946-kq0rsuxj 86 16 generation generation NN cord-291946-kq0rsuxj 86 17 sequencing sequencing NN cord-291946-kq0rsuxj 86 18 from from IN cord-291946-kq0rsuxj 86 19 various various JJ cord-291946-kq0rsuxj 86 20 animal animal NN cord-291946-kq0rsuxj 86 21 species specie NNS cord-291946-kq0rsuxj 86 22 will will MD cord-291946-kq0rsuxj 86 23 reveal reveal VB cord-291946-kq0rsuxj 86 24 an an DT cord-291946-kq0rsuxj 86 25 even even RB cord-291946-kq0rsuxj 86 26 greater great JJR cord-291946-kq0rsuxj 86 27 number number NN cord-291946-kq0rsuxj 86 28 and and CC cord-291946-kq0rsuxj 86 29 genetic genetic JJ cord-291946-kq0rsuxj 86 30 diversity diversity NN cord-291946-kq0rsuxj 86 31 of of IN cord-291946-kq0rsuxj 86 32 EVEs eve NNS cord-291946-kq0rsuxj 86 33 , , , cord-291946-kq0rsuxj 86 34 which which WDT cord-291946-kq0rsuxj 86 35 will will MD cord-291946-kq0rsuxj 86 36 allow allow VB cord-291946-kq0rsuxj 86 37 us -PRON- PRP cord-291946-kq0rsuxj 86 38 to to TO cord-291946-kq0rsuxj 86 39 understand understand VB cord-291946-kq0rsuxj 86 40 better well JJR cord-291946-kq0rsuxj 86 41 the the DT cord-291946-kq0rsuxj 86 42 ancestors ancestor NNS cord-291946-kq0rsuxj 86 43 of of IN cord-291946-kq0rsuxj 86 44 the the DT cord-291946-kq0rsuxj 86 45 modern modern JJ cord-291946-kq0rsuxj 86 46 viruses virus NNS cord-291946-kq0rsuxj 86 47 and and CC cord-291946-kq0rsuxj 86 48 estimate estimate VB cord-291946-kq0rsuxj 86 49 with with IN cord-291946-kq0rsuxj 86 50 greater great JJR cord-291946-kq0rsuxj 86 51 precision precision NN cord-291946-kq0rsuxj 86 52 the the DT cord-291946-kq0rsuxj 86 53 date date NN cord-291946-kq0rsuxj 86 54 of of IN cord-291946-kq0rsuxj 86 55 their -PRON- PRP$ cord-291946-kq0rsuxj 86 56 viral viral JJ cord-291946-kq0rsuxj 86 57 insertion insertion NN cord-291946-kq0rsuxj 86 58 into into IN cord-291946-kq0rsuxj 86 59 the the DT cord-291946-kq0rsuxj 86 60 host host NN cord-291946-kq0rsuxj 86 61 germline germline NN cord-291946-kq0rsuxj 86 62 ( ( -LRB- cord-291946-kq0rsuxj 86 63 Figure figure NN cord-291946-kq0rsuxj 86 64 1 1 CD cord-291946-kq0rsuxj 86 65 ) ) -RRB- cord-291946-kq0rsuxj 86 66 . . . cord-291946-kq0rsuxj 87 1 Thus thus RB cord-291946-kq0rsuxj 87 2 , , , cord-291946-kq0rsuxj 87 3 the the DT cord-291946-kq0rsuxj 87 4 answer answer NN cord-291946-kq0rsuxj 87 5 to to IN cord-291946-kq0rsuxj 87 6 the the DT cord-291946-kq0rsuxj 87 7 question question NN cord-291946-kq0rsuxj 87 8 ' ' '' cord-291946-kq0rsuxj 87 9 ' ' '' cord-291946-kq0rsuxj 87 10 where where WRB cord-291946-kq0rsuxj 87 11 did do VBD cord-291946-kq0rsuxj 87 12 these these DT cord-291946-kq0rsuxj 87 13 viruses virus NNS cord-291946-kq0rsuxj 87 14 come come VB cord-291946-kq0rsuxj 87 15 from from IN cord-291946-kq0rsuxj 87 16 ? ? . cord-291946-kq0rsuxj 87 17 ' ' '' cord-291946-kq0rsuxj 87 18 ' ' '' cord-291946-kq0rsuxj 87 19 will will MD cord-291946-kq0rsuxj 87 20 increasingly increasingly RB cord-291946-kq0rsuxj 87 21 become become VB cord-291946-kq0rsuxj 87 22 ' ' '' cord-291946-kq0rsuxj 87 23 ' ' '' cord-291946-kq0rsuxj 87 24 they -PRON- PRP cord-291946-kq0rsuxj 87 25 came come VBD cord-291946-kq0rsuxj 87 26 from from IN cord-291946-kq0rsuxj 87 27 ancient ancient JJ cord-291946-kq0rsuxj 87 28 forms form NNS cord-291946-kq0rsuxj 87 29 of of IN cord-291946-kq0rsuxj 87 30 other other JJ cord-291946-kq0rsuxj 87 31 viruses virus NNS cord-291946-kq0rsuxj 87 32 , , , cord-291946-kq0rsuxj 87 33 ' ' '' cord-291946-kq0rsuxj 87 34 ' ' '' cord-291946-kq0rsuxj 87 35 although although IN cord-291946-kq0rsuxj 87 36 in in IN cord-291946-kq0rsuxj 87 37 some some DT cord-291946-kq0rsuxj 87 38 cases case NNS cord-291946-kq0rsuxj 87 39 , , , cord-291946-kq0rsuxj 87 40 such such JJ cord-291946-kq0rsuxj 87 41 as as IN cord-291946-kq0rsuxj 87 42 those those DT cord-291946-kq0rsuxj 87 43 described describe VBN cord-291946-kq0rsuxj 87 44 for for IN cord-291946-kq0rsuxj 87 45 REV REV NNP cord-291946-kq0rsuxj 87 46 [ [ -LRB- cord-291946-kq0rsuxj 87 47 21 21 CD cord-291946-kq0rsuxj 87 48 ] ] -RRB- cord-291946-kq0rsuxj 87 49 , , , cord-291946-kq0rsuxj 87 50 they -PRON- PRP cord-291946-kq0rsuxj 87 51 come come VBP cord-291946-kq0rsuxj 87 52 through through IN cord-291946-kq0rsuxj 87 53 a a DT cord-291946-kq0rsuxj 87 54 thoroughly thoroughly RB cord-291946-kq0rsuxj 87 55 circuitous circuitous JJ cord-291946-kq0rsuxj 87 56 route route NN cord-291946-kq0rsuxj 87 57 . . . cord-291946-kq0rsuxj 88 1 While while IN cord-291946-kq0rsuxj 88 2 the the DT cord-291946-kq0rsuxj 88 3 main main JJ cord-291946-kq0rsuxj 88 4 text text NN cord-291946-kq0rsuxj 88 5 describes describe VBZ cord-291946-kq0rsuxj 88 6 the the DT cord-291946-kq0rsuxj 88 7 origins origin NNS cord-291946-kq0rsuxj 88 8 of of IN cord-291946-kq0rsuxj 88 9 the the DT cord-291946-kq0rsuxj 88 10 reticuloendotheliosis reticuloendotheliosis NNP cord-291946-kq0rsuxj 88 11 virus virus NN cord-291946-kq0rsuxj 88 12 ( ( -LRB- cord-291946-kq0rsuxj 88 13 REV REV NNP cord-291946-kq0rsuxj 88 14 ) ) -RRB- cord-291946-kq0rsuxj 88 15 and and CC cord-291946-kq0rsuxj 88 16 its -PRON- PRP$ cord-291946-kq0rsuxj 88 17 close close JJ cord-291946-kq0rsuxj 88 18 relatives relative NNS cord-291946-kq0rsuxj 88 19 as as IN cord-291946-kq0rsuxj 88 20 pathogens pathogen NNS cord-291946-kq0rsuxj 88 21 , , , cord-291946-kq0rsuxj 88 22 the the DT cord-291946-kq0rsuxj 88 23 study study NN cord-291946-kq0rsuxj 88 24 of of IN cord-291946-kq0rsuxj 88 25 these these DT cord-291946-kq0rsuxj 88 26 retroviruses retrovirus NNS cord-291946-kq0rsuxj 88 27 has have VBZ cord-291946-kq0rsuxj 88 28 also also RB cord-291946-kq0rsuxj 88 29 contributed contribute VBN cord-291946-kq0rsuxj 88 30 to to IN cord-291946-kq0rsuxj 88 31 several several JJ cord-291946-kq0rsuxj 88 32 areas area NNS cord-291946-kq0rsuxj 88 33 of of IN cord-291946-kq0rsuxj 88 34 basic basic JJ cord-291946-kq0rsuxj 88 35 science science NN cord-291946-kq0rsuxj 88 36 and and CC cord-291946-kq0rsuxj 88 37 basic basic JJ cord-291946-kq0rsuxj 88 38 virology virology NN cord-291946-kq0rsuxj 88 39 . . . cord-291946-kq0rsuxj 89 1 The the DT cord-291946-kq0rsuxj 89 2 original original JJ cord-291946-kq0rsuxj 89 3 description description NN cord-291946-kq0rsuxj 89 4 of of IN cord-291946-kq0rsuxj 89 5 REV REV NNP cord-291946-kq0rsuxj 89 6 was be VBD cord-291946-kq0rsuxj 89 7 from from IN cord-291946-kq0rsuxj 89 8 a a DT cord-291946-kq0rsuxj 89 9 tumor tumor NN cord-291946-kq0rsuxj 89 10 taken take VBN cord-291946-kq0rsuxj 89 11 from from IN cord-291946-kq0rsuxj 89 12 a a DT cord-291946-kq0rsuxj 89 13 turkey turkey NN cord-291946-kq0rsuxj 89 14 that that WDT cord-291946-kq0rsuxj 89 15 contained contain VBD cord-291946-kq0rsuxj 89 16 two two CD cord-291946-kq0rsuxj 89 17 viruses virus NNS cord-291946-kq0rsuxj 89 18 . . . cord-291946-kq0rsuxj 90 1 One one CD cord-291946-kq0rsuxj 90 2 , , , cord-291946-kq0rsuxj 90 3 REV REV NNP cord-291946-kq0rsuxj 90 4 - - HYPH cord-291946-kq0rsuxj 90 5 A A NNP cord-291946-kq0rsuxj 90 6 , , , cord-291946-kq0rsuxj 90 7 was be VBD cord-291946-kq0rsuxj 90 8 replication replication NN cord-291946-kq0rsuxj 90 9 - - HYPH cord-291946-kq0rsuxj 90 10 competent competent JJ cord-291946-kq0rsuxj 90 11 , , , cord-291946-kq0rsuxj 90 12 and and CC cord-291946-kq0rsuxj 90 13 the the DT cord-291946-kq0rsuxj 90 14 other other JJ cord-291946-kq0rsuxj 90 15 , , , cord-291946-kq0rsuxj 90 16 REV REV NNP cord-291946-kq0rsuxj 90 17 - - HYPH cord-291946-kq0rsuxj 90 18 T T NNP cord-291946-kq0rsuxj 90 19 , , , cord-291946-kq0rsuxj 90 20 was be VBD cord-291946-kq0rsuxj 90 21 defective defective JJ cord-291946-kq0rsuxj 90 22 , , , cord-291946-kq0rsuxj 90 23 but but CC cord-291946-kq0rsuxj 90 24 carried carry VBD cord-291946-kq0rsuxj 90 25 an an DT cord-291946-kq0rsuxj 90 26 oncogene oncogene NN cord-291946-kq0rsuxj 90 27 called call VBN cord-291946-kq0rsuxj 90 28 Rel Rel NNP cord-291946-kq0rsuxj 90 29 that that WDT cord-291946-kq0rsuxj 90 30 allowed allow VBD cord-291946-kq0rsuxj 90 31 it -PRON- PRP cord-291946-kq0rsuxj 90 32 to to TO cord-291946-kq0rsuxj 90 33 transform transform VB cord-291946-kq0rsuxj 90 34 cells cell NNS cord-291946-kq0rsuxj 90 35 [ [ -LRB- cord-291946-kq0rsuxj 90 36 23 23 CD cord-291946-kq0rsuxj 90 37 , , , cord-291946-kq0rsuxj 90 38 24 24 CD cord-291946-kq0rsuxj 90 39 ] ] -RRB- cord-291946-kq0rsuxj 90 40 . . . cord-291946-kq0rsuxj 91 1 Rel Rel NNP cord-291946-kq0rsuxj 91 2 , , , cord-291946-kq0rsuxj 91 3 it -PRON- PRP cord-291946-kq0rsuxj 91 4 turns turn VBZ cord-291946-kq0rsuxj 91 5 out out RP cord-291946-kq0rsuxj 91 6 , , , cord-291946-kq0rsuxj 91 7 is be VBZ cord-291946-kq0rsuxj 91 8 a a DT cord-291946-kq0rsuxj 91 9 key key JJ cord-291946-kq0rsuxj 91 10 component component NN cord-291946-kq0rsuxj 91 11 in in IN cord-291946-kq0rsuxj 91 12 the the DT cord-291946-kq0rsuxj 91 13 innate innate JJ cord-291946-kq0rsuxj 91 14 immune immune JJ cord-291946-kq0rsuxj 91 15 signaling signal VBG cord-291946-kq0rsuxj 91 16 pathway pathway NN cord-291946-kq0rsuxj 91 17 [ [ -LRB- cord-291946-kq0rsuxj 91 18 25 25 CD cord-291946-kq0rsuxj 91 19 ] ] -RRB- cord-291946-kq0rsuxj 91 20 , , , cord-291946-kq0rsuxj 91 21 as as IN cord-291946-kq0rsuxj 91 22 a a DT cord-291946-kq0rsuxj 91 23 component component NN cord-291946-kq0rsuxj 91 24 of of IN cord-291946-kq0rsuxj 91 25 the the DT cord-291946-kq0rsuxj 91 26 NF NF NNP cord-291946-kq0rsuxj 91 27 - - HYPH cord-291946-kq0rsuxj 91 28 kB kb CD cord-291946-kq0rsuxj 91 29 transcription transcription NN cord-291946-kq0rsuxj 91 30 factor factor NN cord-291946-kq0rsuxj 91 31 [ [ -LRB- cord-291946-kq0rsuxj 91 32 26 26 CD cord-291946-kq0rsuxj 91 33 ] ] -RRB- cord-291946-kq0rsuxj 91 34 . . . cord-291946-kq0rsuxj 92 1 The the DT cord-291946-kq0rsuxj 92 2 late late JJ cord-291946-kq0rsuxj 92 3 Howard Howard NNP cord-291946-kq0rsuxj 92 4 Temin Temin NNP cord-291946-kq0rsuxj 92 5 adopted adopt VBD cord-291946-kq0rsuxj 92 6 REV REV NNP cord-291946-kq0rsuxj 92 7 and and CC cord-291946-kq0rsuxj 92 8 related relate VBN cord-291946-kq0rsuxj 92 9 viruses virus NNS cord-291946-kq0rsuxj 92 10 as as IN cord-291946-kq0rsuxj 92 11 model model NN cord-291946-kq0rsuxj 92 12 systems system NNS cord-291946-kq0rsuxj 92 13 to to TO cord-291946-kq0rsuxj 92 14 describe describe VB cord-291946-kq0rsuxj 92 15 , , , cord-291946-kq0rsuxj 92 16 among among IN cord-291946-kq0rsuxj 92 17 many many JJ cord-291946-kq0rsuxj 92 18 other other JJ cord-291946-kq0rsuxj 92 19 phenomena phenomenon NNS cord-291946-kq0rsuxj 92 20 , , , cord-291946-kq0rsuxj 92 21 the the DT cord-291946-kq0rsuxj 92 22 kinetics kinetic NNS cord-291946-kq0rsuxj 92 23 of of IN cord-291946-kq0rsuxj 92 24 retroviral retroviral JJ cord-291946-kq0rsuxj 92 25 infections infection NNS cord-291946-kq0rsuxj 92 26 [ [ -LRB- cord-291946-kq0rsuxj 92 27 27 27 CD cord-291946-kq0rsuxj 92 28 ] ] -RRB- cord-291946-kq0rsuxj 92 29 , , , cord-291946-kq0rsuxj 92 30 the the DT cord-291946-kq0rsuxj 92 31 derivation derivation NN cord-291946-kq0rsuxj 92 32 of of IN cord-291946-kq0rsuxj 92 33 cell cell NN cord-291946-kq0rsuxj 92 34 lines line NNS cord-291946-kq0rsuxj 92 35 for for IN cord-291946-kq0rsuxj 92 36 making make VBG cord-291946-kq0rsuxj 92 37 gene gene NN cord-291946-kq0rsuxj 92 38 therapy therapy NN cord-291946-kq0rsuxj 92 39 vectors vector NNS cord-291946-kq0rsuxj 92 40 [ [ -LRB- cord-291946-kq0rsuxj 92 41 28 28 CD cord-291946-kq0rsuxj 92 42 ] ] -RRB- cord-291946-kq0rsuxj 92 43 , , , cord-291946-kq0rsuxj 92 44 and and CC cord-291946-kq0rsuxj 92 45 retrovirus retrovirus NN cord-291946-kq0rsuxj 92 46 mutation mutation NN cord-291946-kq0rsuxj 92 47 and and CC cord-291946-kq0rsuxj 92 48 recombination recombination NN cord-291946-kq0rsuxj 92 49 rates rate NNS cord-291946-kq0rsuxj 92 50 [ [ -LRB- cord-291946-kq0rsuxj 92 51 29 29 CD cord-291946-kq0rsuxj 92 52 , , , cord-291946-kq0rsuxj 92 53 30 30 CD cord-291946-kq0rsuxj 92 54 ] ] -RRB- cord-291946-kq0rsuxj 92 55 . . . cord-291946-kq0rsuxj 93 1 Global global JJ cord-291946-kq0rsuxj 93 2 trends trend NNS cord-291946-kq0rsuxj 93 3 in in IN cord-291946-kq0rsuxj 93 4 emerging emerge VBG cord-291946-kq0rsuxj 93 5 infectious infectious JJ cord-291946-kq0rsuxj 93 6 diseases disease NNS cord-291946-kq0rsuxj 93 7 SARS SARS NNP cord-291946-kq0rsuxj 93 8 - - HYPH cord-291946-kq0rsuxj 93 9 CoV CoV NNP cord-291946-kq0rsuxj 93 10 and and CC cord-291946-kq0rsuxj 93 11 emergent emergent JJ cord-291946-kq0rsuxj 93 12 coronaviruses coronaviruse NNS cord-291946-kq0rsuxj 93 13 : : : cord-291946-kq0rsuxj 93 14 Viral viral JJ cord-291946-kq0rsuxj 93 15 determinants determinant NNS cord-291946-kq0rsuxj 93 16 of of IN cord-291946-kq0rsuxj 93 17 interspecies interspecie NNS cord-291946-kq0rsuxj 93 18 transmission transmission NN cord-291946-kq0rsuxj 94 1 The the DT cord-291946-kq0rsuxj 94 2 great great JJ cord-291946-kq0rsuxj 94 3 influenza influenza NN cord-291946-kq0rsuxj 94 4 : : : cord-291946-kq0rsuxj 95 1 The the DT cord-291946-kq0rsuxj 95 2 story story NN cord-291946-kq0rsuxj 95 3 of of IN cord-291946-kq0rsuxj 95 4 the the DT cord-291946-kq0rsuxj 95 5 deadliest deadly JJS cord-291946-kq0rsuxj 95 6 pandemic pandemic NN cord-291946-kq0rsuxj 95 7 in in IN cord-291946-kq0rsuxj 95 8 history history NN cord-291946-kq0rsuxj 95 9 . . . cord-291946-kq0rsuxj 96 1 Penguin Penguin NNP cord-291946-kq0rsuxj 96 2 Books Books NNP cord-291946-kq0rsuxj 96 3 Crossspecies Crossspecies NNP cord-291946-kq0rsuxj 96 4 virus virus NN cord-291946-kq0rsuxj 96 5 transmission transmission NN cord-291946-kq0rsuxj 96 6 and and CC cord-291946-kq0rsuxj 96 7 the the DT cord-291946-kq0rsuxj 96 8 emergence emergence NN cord-291946-kq0rsuxj 96 9 of of IN cord-291946-kq0rsuxj 96 10 new new JJ cord-291946-kq0rsuxj 96 11 epidemic epidemic NN cord-291946-kq0rsuxj 96 12 diseases disease NNS cord-291946-kq0rsuxj 96 13 Emerging emerge VBG cord-291946-kq0rsuxj 96 14 virus virus NN cord-291946-kq0rsuxj 96 15 diseases disease NNS cord-291946-kq0rsuxj 97 1 : : : cord-291946-kq0rsuxj 97 2 Can Can MD cord-291946-kq0rsuxj 97 3 we -PRON- PRP cord-291946-kq0rsuxj 97 4 ever ever RB cord-291946-kq0rsuxj 97 5 expect expect VB cord-291946-kq0rsuxj 97 6 the the DT cord-291946-kq0rsuxj 97 7 unexpected unexpected JJ cord-291946-kq0rsuxj 97 8 ? ? . cord-291946-kq0rsuxj 98 1 How how WRB cord-291946-kq0rsuxj 98 2 the the DT cord-291946-kq0rsuxj 98 3 cows cow NNS cord-291946-kq0rsuxj 98 4 turned turn VBD cord-291946-kq0rsuxj 98 5 mad mad JJ cord-291946-kq0rsuxj 98 6 : : : cord-291946-kq0rsuxj 98 7 Unlocking unlock VBG cord-291946-kq0rsuxj 98 8 the the DT cord-291946-kq0rsuxj 98 9 mysteries mystery NNS cord-291946-kq0rsuxj 98 10 of of IN cord-291946-kq0rsuxj 98 11 mad mad JJ cord-291946-kq0rsuxj 98 12 cow cow NN cord-291946-kq0rsuxj 98 13 disease disease NN cord-291946-kq0rsuxj 98 14 . . . cord-291946-kq0rsuxj 99 1 Schneider Schneider NNP cord-291946-kq0rsuxj 99 2 E E NNP cord-291946-kq0rsuxj 99 3 , , , cord-291946-kq0rsuxj 99 4 translator translator NN cord-291946-kq0rsuxj 99 5 Molecular molecular JJ cord-291946-kq0rsuxj 99 6 epidemiology epidemiology NN cord-291946-kq0rsuxj 99 7 of of IN cord-291946-kq0rsuxj 100 1 simian simian JJ cord-291946-kq0rsuxj 100 2 immunodeficiency immunodeficiency NN cord-291946-kq0rsuxj 100 3 virus virus NN cord-291946-kq0rsuxj 100 4 SIVsm SIVsm NNP cord-291946-kq0rsuxj 100 5 in in IN cord-291946-kq0rsuxj 100 6 U.S. U.S. NNP cord-291946-kq0rsuxj 100 7 primate primate NN cord-291946-kq0rsuxj 100 8 centers center NNS cord-291946-kq0rsuxj 100 9 unravels unravel VBZ cord-291946-kq0rsuxj 100 10 the the DT cord-291946-kq0rsuxj 100 11 origin origin NN cord-291946-kq0rsuxj 100 12 of of IN cord-291946-kq0rsuxj 100 13 SIVmac SIVmac NNP cord-291946-kq0rsuxj 100 14 and and CC cord-291946-kq0rsuxj 100 15 SIVstm SIVstm NNP cord-291946-kq0rsuxj 101 1 The the DT cord-291946-kq0rsuxj 101 2 epidemiology epidemiology NN cord-291946-kq0rsuxj 101 3 and and CC cord-291946-kq0rsuxj 101 4 iatrogenic iatrogenic JJ cord-291946-kq0rsuxj 101 5 transmission transmission NN cord-291946-kq0rsuxj 101 6 of of IN cord-291946-kq0rsuxj 101 7 hepatitis hepatitis NN cord-291946-kq0rsuxj 101 8 C C NNP cord-291946-kq0rsuxj 101 9 virus virus NN cord-291946-kq0rsuxj 101 10 in in IN cord-291946-kq0rsuxj 101 11 Egypt Egypt NNP cord-291946-kq0rsuxj 101 12 : : : cord-291946-kq0rsuxj 102 1 A a DT cord-291946-kq0rsuxj 102 2 Bayesian bayesian JJ cord-291946-kq0rsuxj 102 3 coalescent coalescent NN cord-291946-kq0rsuxj 102 4 approach approach NN cord-291946-kq0rsuxj 103 1 The the DT cord-291946-kq0rsuxj 103 2 origin origin NN cord-291946-kq0rsuxj 103 3 of of IN cord-291946-kq0rsuxj 103 4 AIDS AIDS NNP cord-291946-kq0rsuxj 103 5 Endogenous endogenous JJ cord-291946-kq0rsuxj 103 6 viral viral JJ cord-291946-kq0rsuxj 103 7 elements element NNS cord-291946-kq0rsuxj 103 8 in in IN cord-291946-kq0rsuxj 103 9 animal animal NN cord-291946-kq0rsuxj 103 10 genomes genome NNS cord-291946-kq0rsuxj 103 11 Paleovirology Paleovirology NNP cord-291946-kq0rsuxj 103 12 -Ghosts -ghost VBZ cord-291946-kq0rsuxj 103 13 and and CC cord-291946-kq0rsuxj 103 14 gifts gift NNS cord-291946-kq0rsuxj 103 15 of of IN cord-291946-kq0rsuxj 103 16 viruses virus NNS cord-291946-kq0rsuxj 103 17 past past IN cord-291946-kq0rsuxj 103 18 Genomic genomic JJ cord-291946-kq0rsuxj 103 19 fossils fossil NNS cord-291946-kq0rsuxj 103 20 calibrate calibrate VBP cord-291946-kq0rsuxj 103 21 the the DT cord-291946-kq0rsuxj 103 22 long long JJ cord-291946-kq0rsuxj 103 23 - - HYPH cord-291946-kq0rsuxj 103 24 term term NN cord-291946-kq0rsuxj 103 25 evolution evolution NN cord-291946-kq0rsuxj 103 26 of of IN cord-291946-kq0rsuxj 103 27 hepadnaviruses hepadnavirus NNS cord-291946-kq0rsuxj 104 1 A a DT cord-291946-kq0rsuxj 104 2 transitional transitional JJ cord-291946-kq0rsuxj 104 3 endogenous endogenous JJ cord-291946-kq0rsuxj 104 4 lentivirus lentivirus NN cord-291946-kq0rsuxj 104 5 from from IN cord-291946-kq0rsuxj 104 6 the the DT cord-291946-kq0rsuxj 104 7 genome genome NN cord-291946-kq0rsuxj 104 8 of of IN cord-291946-kq0rsuxj 104 9 a a DT cord-291946-kq0rsuxj 104 10 basal basal NN cord-291946-kq0rsuxj 104 11 primate primate NN cord-291946-kq0rsuxj 104 12 and and CC cord-291946-kq0rsuxj 104 13 implications implication NNS cord-291946-kq0rsuxj 104 14 for for IN cord-291946-kq0rsuxj 104 15 lentivirus lentivirus NN cord-291946-kq0rsuxj 104 16 evolution evolution NN cord-291946-kq0rsuxj 104 17 Interclass Interclass NNP cord-291946-kq0rsuxj 104 18 transmission transmission NN cord-291946-kq0rsuxj 104 19 and and CC cord-291946-kq0rsuxj 104 20 phyletic phyletic JJ cord-291946-kq0rsuxj 104 21 host host NN cord-291946-kq0rsuxj 104 22 tracking tracking NN cord-291946-kq0rsuxj 104 23 in in IN cord-291946-kq0rsuxj 104 24 murine murine JJ cord-291946-kq0rsuxj 104 25 leukemia leukemia NN cord-291946-kq0rsuxj 104 26 virus virus NN cord-291946-kq0rsuxj 104 27 - - HYPH cord-291946-kq0rsuxj 104 28 related relate VBN cord-291946-kq0rsuxj 104 29 retroviruses retrovirus NNS cord-291946-kq0rsuxj 104 30 Origins origin NNS cord-291946-kq0rsuxj 104 31 of of IN cord-291946-kq0rsuxj 104 32 major major JJ cord-291946-kq0rsuxj 104 33 human human JJ cord-291946-kq0rsuxj 104 34 infectious infectious JJ cord-291946-kq0rsuxj 104 35 diseases disease NNS cord-291946-kq0rsuxj 105 1 Multiple multiple JJ cord-291946-kq0rsuxj 105 2 groups group NNS cord-291946-kq0rsuxj 105 3 of of IN cord-291946-kq0rsuxj 105 4 endogenous endogenous JJ cord-291946-kq0rsuxj 105 5 betaretroviruses betaretroviruse NNS cord-291946-kq0rsuxj 105 6 in in IN cord-291946-kq0rsuxj 105 7 mice mouse NNS cord-291946-kq0rsuxj 105 8 , , , cord-291946-kq0rsuxj 105 9 rats rat NNS cord-291946-kq0rsuxj 105 10 , , , cord-291946-kq0rsuxj 105 11 and and CC cord-291946-kq0rsuxj 105 12 other other JJ cord-291946-kq0rsuxj 105 13 mammals mammal NNS cord-291946-kq0rsuxj 105 14 Identification identification NN cord-291946-kq0rsuxj 105 15 of of IN cord-291946-kq0rsuxj 105 16 diverse diverse JJ cord-291946-kq0rsuxj 105 17 full full JJ cord-291946-kq0rsuxj 105 18 - - HYPH cord-291946-kq0rsuxj 105 19 length length NN cord-291946-kq0rsuxj 105 20 endogenous endogenous JJ cord-291946-kq0rsuxj 105 21 betaretroviruses betaretroviruse NNS cord-291946-kq0rsuxj 105 22 in in IN cord-291946-kq0rsuxj 105 23 megabats megabat NNS cord-291946-kq0rsuxj 105 24 and and CC cord-291946-kq0rsuxj 105 25 microbats microbats NNP cord-291946-kq0rsuxj 106 1 A a DT cord-291946-kq0rsuxj 106 2 novel novel JJ cord-291946-kq0rsuxj 106 3 endogenous endogenous JJ cord-291946-kq0rsuxj 106 4 betaretrovirus betaretrovirus NNP cord-291946-kq0rsuxj 106 5 group group NN cord-291946-kq0rsuxj 106 6 characterized characterize VBN cord-291946-kq0rsuxj 106 7 from from IN cord-291946-kq0rsuxj 106 8 polar polar JJ cord-291946-kq0rsuxj 106 9 bears bear NNS cord-291946-kq0rsuxj 106 10 ( ( -LRB- cord-291946-kq0rsuxj 106 11 Ursus Ursus NNP cord-291946-kq0rsuxj 106 12 maritimus maritimus NNP cord-291946-kq0rsuxj 106 13 ) ) -RRB- cord-291946-kq0rsuxj 106 14 and and CC cord-291946-kq0rsuxj 106 15 giant giant JJ cord-291946-kq0rsuxj 106 16 pandas panda NNS cord-291946-kq0rsuxj 106 17 ( ( -LRB- cord-291946-kq0rsuxj 106 18 Ailuropoda Ailuropoda NNP cord-291946-kq0rsuxj 106 19 melanoleuca melanoleuca NNP cord-291946-kq0rsuxj 106 20 ) ) -RRB- cord-291946-kq0rsuxj 107 1 Retrovirus retrovirus NN cord-291946-kq0rsuxj 107 2 insertion insertion NN cord-291946-kq0rsuxj 107 3 into into IN cord-291946-kq0rsuxj 107 4 herpesviruses herpesviruses NNP cord-291946-kq0rsuxj 107 5 Field field NN cord-291946-kq0rsuxj 107 6 and and CC cord-291946-kq0rsuxj 107 7 vaccine vaccine NN cord-291946-kq0rsuxj 107 8 strains strain NNS cord-291946-kq0rsuxj 107 9 of of IN cord-291946-kq0rsuxj 107 10 fowlpox fowlpox NNP cord-291946-kq0rsuxj 107 11 virus virus NN cord-291946-kq0rsuxj 107 12 carry carry VBP cord-291946-kq0rsuxj 107 13 integrated integrated JJ cord-291946-kq0rsuxj 107 14 sequences sequence NNS cord-291946-kq0rsuxj 107 15 from from IN cord-291946-kq0rsuxj 107 16 the the DT cord-291946-kq0rsuxj 107 17 avian avian JJ cord-291946-kq0rsuxj 107 18 retrovirus retrovirus NN cord-291946-kq0rsuxj 107 19 , , , cord-291946-kq0rsuxj 107 20 reticuloen reticuloen NNP cord-291946-kq0rsuxj 107 21 dotheliosis dotheliosis NNP cord-291946-kq0rsuxj 107 22 virus virus NN cord-291946-kq0rsuxj 108 1 The the DT cord-291946-kq0rsuxj 108 2 extraordinary extraordinary JJ cord-291946-kq0rsuxj 108 3 evolutionary evolutionary JJ cord-291946-kq0rsuxj 108 4 history history NN cord-291946-kq0rsuxj 108 5 of of IN cord-291946-kq0rsuxj 108 6 the the DT cord-291946-kq0rsuxj 108 7 reticuloendotheliosis reticuloendotheliosis NN cord-291946-kq0rsuxj 108 8 viruses virus NNS cord-291946-kq0rsuxj 108 9 Bats bat NNS cord-291946-kq0rsuxj 108 10 are be VBP cord-291946-kq0rsuxj 108 11 a a DT cord-291946-kq0rsuxj 108 12 major major JJ cord-291946-kq0rsuxj 108 13 natural natural JJ cord-291946-kq0rsuxj 108 14 reservoir reservoir NN cord-291946-kq0rsuxj 108 15 for for IN cord-291946-kq0rsuxj 108 16 hepaciviruses hepaciviruse NNS cord-291946-kq0rsuxj 108 17 and and CC cord-291946-kq0rsuxj 109 1 pegiviruses pegiviruses NNP cord-291946-kq0rsuxj 109 2 Characterization Characterization NNP cord-291946-kq0rsuxj 109 3 of of IN cord-291946-kq0rsuxj 109 4 reticuloendotheliosis reticuloendotheliosis NNP cord-291946-kq0rsuxj 109 5 virus virus NN cord-291946-kq0rsuxj 109 6 strain strain VBP cord-291946-kq0rsuxj 109 7 T T NNP cord-291946-kq0rsuxj 109 8 DNA dna NN cord-291946-kq0rsuxj 109 9 and and CC cord-291946-kq0rsuxj 109 10 isolation isolation NN cord-291946-kq0rsuxj 109 11 of of IN cord-291946-kq0rsuxj 109 12 a a DT cord-291946-kq0rsuxj 109 13 novel novel JJ cord-291946-kq0rsuxj 109 14 variant variant NN cord-291946-kq0rsuxj 109 15 of of IN cord-291946-kq0rsuxj 109 16 reticuloendotheliosis reticuloendotheliosis NNP cord-291946-kq0rsuxj 109 17 virus virus NN cord-291946-kq0rsuxj 110 1 strain strain VB cord-291946-kq0rsuxj 110 2 T T NNP cord-291946-kq0rsuxj 110 3 by by IN cord-291946-kq0rsuxj 110 4 molecular molecular JJ cord-291946-kq0rsuxj 110 5 cloning clone VBG cord-291946-kq0rsuxj 110 6 Nucleotide nucleotide JJ cord-291946-kq0rsuxj 110 7 sequence sequence NN cord-291946-kq0rsuxj 110 8 of of IN cord-291946-kq0rsuxj 110 9 v v NN cord-291946-kq0rsuxj 110 10 - - HYPH cord-291946-kq0rsuxj 110 11 rel rel NNP cord-291946-kq0rsuxj 110 12 : : : cord-291946-kq0rsuxj 111 1 The the DT cord-291946-kq0rsuxj 111 2 oncogene oncogene NN cord-291946-kq0rsuxj 111 3 of of IN cord-291946-kq0rsuxj 111 4 reticuloendotheliosis reticuloendotheliosis NN cord-291946-kq0rsuxj 111 5 virus virus NN cord-291946-kq0rsuxj 111 6 Regulated Regulated NNP cord-291946-kq0rsuxj 111 7 nuclear nuclear JJ cord-291946-kq0rsuxj 111 8 import import NN cord-291946-kq0rsuxj 111 9 of of IN cord-291946-kq0rsuxj 111 10 Rel Rel NNP cord-291946-kq0rsuxj 111 11 proteins protein NNS cord-291946-kq0rsuxj 111 12 in in IN cord-291946-kq0rsuxj 111 13 the the DT cord-291946-kq0rsuxj 111 14 Drosophila drosophila JJ cord-291946-kq0rsuxj 111 15 immune immune JJ cord-291946-kq0rsuxj 111 16 response response NN cord-291946-kq0rsuxj 111 17 NF nf NN cord-291946-kq0rsuxj 111 18 - - HYPH cord-291946-kq0rsuxj 111 19 kappa kappa NN cord-291946-kq0rsuxj 111 20 B B NNP cord-291946-kq0rsuxj 111 21 , , , cord-291946-kq0rsuxj 111 22 KBF1 KBF1 NNP cord-291946-kq0rsuxj 111 23 , , , cord-291946-kq0rsuxj 111 24 dorsal dorsal JJ cord-291946-kq0rsuxj 111 25 , , , cord-291946-kq0rsuxj 111 26 and and CC cord-291946-kq0rsuxj 111 27 related related JJ cord-291946-kq0rsuxj 111 28 matters matter NNS cord-291946-kq0rsuxj 112 1 Replication replication NN cord-291946-kq0rsuxj 112 2 of of IN cord-291946-kq0rsuxj 112 3 reticuloendotheliosis reticuloendotheliosis NN cord-291946-kq0rsuxj 112 4 viruses virus NNS cord-291946-kq0rsuxj 112 5 in in IN cord-291946-kq0rsuxj 112 6 cell cell NN cord-291946-kq0rsuxj 112 7 culture culture NN cord-291946-kq0rsuxj 112 8 : : : cord-291946-kq0rsuxj 112 9 acute acute JJ cord-291946-kq0rsuxj 112 10 infection infection NN cord-291946-kq0rsuxj 112 11 Construction construction NN cord-291946-kq0rsuxj 112 12 of of IN cord-291946-kq0rsuxj 112 13 a a DT cord-291946-kq0rsuxj 112 14 helper helper NN cord-291946-kq0rsuxj 112 15 cell cell NN cord-291946-kq0rsuxj 112 16 line line NN cord-291946-kq0rsuxj 112 17 for for IN cord-291946-kq0rsuxj 112 18 avian avian JJ cord-291946-kq0rsuxj 112 19 reticuloendotheliosis reticuloendotheliosis NN cord-291946-kq0rsuxj 112 20 virus virus NN cord-291946-kq0rsuxj 112 21 cloning clone VBG cord-291946-kq0rsuxj 112 22 vectors vector NNS cord-291946-kq0rsuxj 112 23 Lower lower RBR cord-291946-kq0rsuxj 112 24 in in IN cord-291946-kq0rsuxj 112 25 vivo vivo NN cord-291946-kq0rsuxj 112 26 mutation mutation NN cord-291946-kq0rsuxj 112 27 rate rate NN cord-291946-kq0rsuxj 112 28 of of IN cord-291946-kq0rsuxj 112 29 human human JJ cord-291946-kq0rsuxj 112 30 immunodeficiency immunodeficiency NN cord-291946-kq0rsuxj 112 31 virus virus NN cord-291946-kq0rsuxj 112 32 type type NN cord-291946-kq0rsuxj 112 33 1 1 CD cord-291946-kq0rsuxj 113 1 than than IN cord-291946-kq0rsuxj 113 2 that that DT cord-291946-kq0rsuxj 113 3 predicted predict VBD cord-291946-kq0rsuxj 113 4 from from IN cord-291946-kq0rsuxj 113 5 the the DT cord-291946-kq0rsuxj 113 6 fidelity fidelity NN cord-291946-kq0rsuxj 113 7 of of IN cord-291946-kq0rsuxj 113 8 purified purify VBN cord-291946-kq0rsuxj 113 9 reverse reverse NN cord-291946-kq0rsuxj 113 10 transcriptase transcriptase NN cord-291946-kq0rsuxj 113 11 Retroviral retroviral NN cord-291946-kq0rsuxj 113 12 recombination recombination NN cord-291946-kq0rsuxj 113 13 and and CC cord-291946-kq0rsuxj 113 14 reverse reverse VB cord-291946-kq0rsuxj 113 15 transcription transcription NN cord-291946-kq0rsuxj 114 1 We -PRON- PRP cord-291946-kq0rsuxj 114 2 thank thank VBP cord-291946-kq0rsuxj 114 3 Kristopher Kristopher NNP cord-291946-kq0rsuxj 114 4 Azarm Azarm NNP cord-291946-kq0rsuxj 114 5 , , , cord-291946-kq0rsuxj 114 6 Jesse Jesse NNP cord-291946-kq0rsuxj 114 7 Bloom Bloom NNP cord-291946-kq0rsuxj 114 8 , , , cord-291946-kq0rsuxj 114 9 Patrick Patrick NNP cord-291946-kq0rsuxj 114 10 Mitchell Mitchell NNP cord-291946-kq0rsuxj 114 11 , , , cord-291946-kq0rsuxj 114 12 Cristina Cristina NNP cord-291946-kq0rsuxj 114 13 Wittkopp Wittkopp NNP cord-291946-kq0rsuxj 114 14 , , , cord-291946-kq0rsuxj 114 15 and and CC cord-291946-kq0rsuxj 114 16 Janet Janet NNP cord-291946-kq0rsuxj 114 17 Young Young NNP cord-291946-kq0rsuxj 114 18 for for IN cord-291946-kq0rsuxj 114 19 their -PRON- PRP$ cord-291946-kq0rsuxj 114 20 comments comment NNS cord-291946-kq0rsuxj 114 21 . . .