id	sid	tid	token	lemma	pos
cord-277417-f71jwdzj	1	1	key	key	JJ
cord-277417-f71jwdzj	1	2	:	:	:
cord-277417-f71jwdzj	1	3	cord-277417-f71jwdzj	cord-277417-f71jwdzj	NNS
cord-277417-f71jwdzj	1	4	authors	author	NNS
cord-277417-f71jwdzj	1	5	:	:	:
cord-277417-f71jwdzj	1	6	Geoghegan	Geoghegan	NNP
cord-277417-f71jwdzj	1	7	,	,	,
cord-277417-f71jwdzj	1	8	Jemma	Jemma	NNP
cord-277417-f71jwdzj	1	9	L.	L.	NNP
cord-277417-f71jwdzj	1	10	;	;	:
cord-277417-f71jwdzj	1	11	Holmes	Holmes	NNP
cord-277417-f71jwdzj	1	12	,	,	,
cord-277417-f71jwdzj	2	1	Edward	Edward	NNP
cord-277417-f71jwdzj	2	2	C.	C.	NNP
cord-277417-f71jwdzj	2	3	title	title	NN
cord-277417-f71jwdzj	2	4	:	:	:
cord-277417-f71jwdzj	3	1	The	the	DT
cord-277417-f71jwdzj	3	2	phylogenomics	phylogenomic	NNS
cord-277417-f71jwdzj	3	3	of	of	IN
cord-277417-f71jwdzj	3	4	evolving	evolve	VBG
cord-277417-f71jwdzj	3	5	virus	virus	NN
cord-277417-f71jwdzj	3	6	virulence	virulence	NN
cord-277417-f71jwdzj	3	7	date	date	NN
cord-277417-f71jwdzj	3	8	:	:	:
cord-277417-f71jwdzj	3	9	2018	2018	CD
cord-277417-f71jwdzj	3	10	-	-	SYM
cord-277417-f71jwdzj	3	11	10	10	CD
cord-277417-f71jwdzj	3	12	-	-	SYM
cord-277417-f71jwdzj	3	13	10	10	CD
cord-277417-f71jwdzj	3	14	journal	journal	NN
cord-277417-f71jwdzj	3	15	:	:	:
cord-277417-f71jwdzj	4	1	Nat	Nat	NNP
cord-277417-f71jwdzj	4	2	Rev	Rev	NNP
cord-277417-f71jwdzj	4	3	Genet	Genet	NNP
cord-277417-f71jwdzj	4	4	DOI	DOI	NNP
cord-277417-f71jwdzj	4	5	:	:	:
cord-277417-f71jwdzj	5	1	10.1038	10.1038	CD
cord-277417-f71jwdzj	5	2	/	/	SYM
cord-277417-f71jwdzj	5	3	s41576	s41576	NNP
cord-277417-f71jwdzj	5	4	-	-	HYPH
cord-277417-f71jwdzj	5	5	018	018	CD
cord-277417-f71jwdzj	5	6	-	-	HYPH
cord-277417-f71jwdzj	5	7	0055	0055	CD
cord-277417-f71jwdzj	5	8	-	-	SYM
cord-277417-f71jwdzj	5	9	5	5	CD
cord-277417-f71jwdzj	5	10	sha	sha	NN
cord-277417-f71jwdzj	5	11	:	:	:
cord-277417-f71jwdzj	6	1	24a0a5830db6f612eb1579993fe923dd8fb58a99	24a0a5830db6f612eb1579993fe923dd8fb58a99	CD
cord-277417-f71jwdzj	7	1	doc_id	doc_id	CD
cord-277417-f71jwdzj	7	2	:	:	:
cord-277417-f71jwdzj	7	3	277417	277417	CD
cord-277417-f71jwdzj	7	4	cord_uid	cord_uid	NNS
cord-277417-f71jwdzj	7	5	:	:	:
cord-277417-f71jwdzj	8	1	f71jwdzj	f71jwdzj	NNPS
cord-277417-f71jwdzj	9	1	How	how	WRB
cord-277417-f71jwdzj	9	2	virulence	virulence	NN
cord-277417-f71jwdzj	9	3	evolves	evolve	VBZ
cord-277417-f71jwdzj	9	4	after	after	IN
cord-277417-f71jwdzj	9	5	a	a	DT
cord-277417-f71jwdzj	9	6	virus	virus	NN
cord-277417-f71jwdzj	9	7	jumps	jump	VBZ
cord-277417-f71jwdzj	9	8	to	to	IN
cord-277417-f71jwdzj	9	9	a	a	DT
cord-277417-f71jwdzj	9	10	new	new	JJ
cord-277417-f71jwdzj	9	11	host	host	NN
cord-277417-f71jwdzj	9	12	species	species	NN
cord-277417-f71jwdzj	9	13	is	be	VBZ
cord-277417-f71jwdzj	9	14	central	central	JJ
cord-277417-f71jwdzj	9	15	to	to	IN
cord-277417-f71jwdzj	9	16	disease	disease	NN
cord-277417-f71jwdzj	9	17	emergence	emergence	NN
cord-277417-f71jwdzj	9	18	.	.	.
cord-277417-f71jwdzj	10	1	Our	-PRON-	PRP$
cord-277417-f71jwdzj	10	2	current	current	JJ
cord-277417-f71jwdzj	10	3	understanding	understanding	NN
cord-277417-f71jwdzj	10	4	of	of	IN
cord-277417-f71jwdzj	10	5	virulence	virulence	NN
cord-277417-f71jwdzj	10	6	evolution	evolution	NN
cord-277417-f71jwdzj	10	7	is	be	VBZ
cord-277417-f71jwdzj	10	8	based	base	VBN
cord-277417-f71jwdzj	10	9	on	on	IN
cord-277417-f71jwdzj	10	10	insights	insight	NNS
cord-277417-f71jwdzj	10	11	drawn	draw	VBN
cord-277417-f71jwdzj	10	12	from	from	IN
cord-277417-f71jwdzj	10	13	two	two	CD
cord-277417-f71jwdzj	10	14	perspectives	perspective	NNS
cord-277417-f71jwdzj	10	15	that	that	WDT
cord-277417-f71jwdzj	10	16	have	have	VBP
cord-277417-f71jwdzj	10	17	developed	develop	VBN
cord-277417-f71jwdzj	10	18	largely	largely	RB
cord-277417-f71jwdzj	10	19	independently	independently	RB
cord-277417-f71jwdzj	10	20	:	:	:
cord-277417-f71jwdzj	10	21	long	long	RB
cord-277417-f71jwdzj	10	22	-	-	HYPH
cord-277417-f71jwdzj	10	23	standing	stand	VBG
cord-277417-f71jwdzj	10	24	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	10	25	theory	theory	NN
cord-277417-f71jwdzj	10	26	based	base	VBN
cord-277417-f71jwdzj	10	27	on	on	IN
cord-277417-f71jwdzj	10	28	limited	limited	JJ
cord-277417-f71jwdzj	10	29	real	real	JJ
cord-277417-f71jwdzj	10	30	data	datum	NNS
cord-277417-f71jwdzj	10	31	examples	example	NNS
cord-277417-f71jwdzj	10	32	that	that	WDT
cord-277417-f71jwdzj	10	33	often	often	RB
cord-277417-f71jwdzj	10	34	lack	lack	VBP
cord-277417-f71jwdzj	10	35	a	a	DT
cord-277417-f71jwdzj	10	36	genomic	genomic	JJ
cord-277417-f71jwdzj	10	37	basis	basis	NN
cord-277417-f71jwdzj	10	38	,	,	,
cord-277417-f71jwdzj	10	39	and	and	CC
cord-277417-f71jwdzj	10	40	experimental	experimental	JJ
cord-277417-f71jwdzj	10	41	studies	study	NNS
cord-277417-f71jwdzj	10	42	of	of	IN
cord-277417-f71jwdzj	10	43	virulence	virulence	NN
cord-277417-f71jwdzj	10	44	-	-	HYPH
cord-277417-f71jwdzj	10	45	determining	determine	VBG
cord-277417-f71jwdzj	10	46	mutations	mutation	NNS
cord-277417-f71jwdzj	10	47	using	use	VBG
cord-277417-f71jwdzj	10	48	cell	cell	NN
cord-277417-f71jwdzj	10	49	culture	culture	NN
cord-277417-f71jwdzj	10	50	or	or	CC
cord-277417-f71jwdzj	10	51	animal	animal	NN
cord-277417-f71jwdzj	10	52	models	model	NNS
cord-277417-f71jwdzj	10	53	.	.	.
cord-277417-f71jwdzj	11	1	A	a	DT
cord-277417-f71jwdzj	11	2	more	more	RBR
cord-277417-f71jwdzj	11	3	comprehensive	comprehensive	JJ
cord-277417-f71jwdzj	11	4	understanding	understanding	NN
cord-277417-f71jwdzj	11	5	of	of	IN
cord-277417-f71jwdzj	11	6	virulence	virulence	NN
cord-277417-f71jwdzj	11	7	mutations	mutation	NNS
cord-277417-f71jwdzj	11	8	and	and	CC
cord-277417-f71jwdzj	11	9	their	-PRON-	PRP$
cord-277417-f71jwdzj	11	10	evolution	evolution	NN
cord-277417-f71jwdzj	11	11	can	can	MD
cord-277417-f71jwdzj	11	12	be	be	VB
cord-277417-f71jwdzj	11	13	achieved	achieve	VBN
cord-277417-f71jwdzj	11	14	by	by	IN
cord-277417-f71jwdzj	11	15	bridging	bridge	VBG
cord-277417-f71jwdzj	11	16	the	the	DT
cord-277417-f71jwdzj	11	17	gap	gap	NN
cord-277417-f71jwdzj	11	18	between	between	IN
cord-277417-f71jwdzj	11	19	these	these	DT
cord-277417-f71jwdzj	11	20	two	two	CD
cord-277417-f71jwdzj	11	21	research	research	NN
cord-277417-f71jwdzj	11	22	pathways	pathway	NNS
cord-277417-f71jwdzj	11	23	through	through	IN
cord-277417-f71jwdzj	11	24	the	the	DT
cord-277417-f71jwdzj	11	25	phylogenomic	phylogenomic	NNP
cord-277417-f71jwdzj	11	26	analysis	analysis	NNP
cord-277417-f71jwdzj	11	27	of	of	IN
cord-277417-f71jwdzj	11	28	virus	virus	NN
cord-277417-f71jwdzj	11	29	genome	genome	NN
cord-277417-f71jwdzj	11	30	sequence	sequence	NN
cord-277417-f71jwdzj	11	31	data	datum	NNS
cord-277417-f71jwdzj	11	32	as	as	IN
cord-277417-f71jwdzj	11	33	a	a	DT
cord-277417-f71jwdzj	11	34	guide	guide	NN
cord-277417-f71jwdzj	11	35	to	to	IN
cord-277417-f71jwdzj	11	36	experimental	experimental	JJ
cord-277417-f71jwdzj	11	37	study	study	NN
cord-277417-f71jwdzj	11	38	.	.	.
cord-277417-f71jwdzj	12	1	Despite	despite	IN
cord-277417-f71jwdzj	12	2	many	many	JJ
cord-277417-f71jwdzj	12	3	advances	advance	NNS
cord-277417-f71jwdzj	12	4	in	in	IN
cord-277417-f71jwdzj	12	5	our	-PRON-	PRP$
cord-277417-f71jwdzj	12	6	understanding	understanding	NN
cord-277417-f71jwdzj	12	7	of	of	IN
cord-277417-f71jwdzj	12	8	virus	virus	NN
cord-277417-f71jwdzj	12	9	evolution	evolution	NN
cord-277417-f71jwdzj	12	10	,	,	,
cord-277417-f71jwdzj	12	11	how	how	WRB
cord-277417-f71jwdzj	12	12	virulence	virulence	NN
cord-277417-f71jwdzj	12	13	evolves	evolve	VBZ
cord-277417-f71jwdzj	12	14	in	in	IN
cord-277417-f71jwdzj	12	15	a	a	DT
cord-277417-f71jwdzj	12	16	virus	virus	NN
cord-277417-f71jwdzj	12	17	,	,	,
cord-277417-f71jwdzj	12	18	particularly	particularly	RB
cord-277417-f71jwdzj	12	19	following	follow	VBG
cord-277417-f71jwdzj	12	20	a	a	DT
cord-277417-f71jwdzj	12	21	jump	jump	NN
cord-277417-f71jwdzj	12	22	to	to	IN
cord-277417-f71jwdzj	12	23	a	a	DT
cord-277417-f71jwdzj	12	24	new	new	JJ
cord-277417-f71jwdzj	12	25	host	host	NN
cord-277417-f71jwdzj	12	26	species	specie	NNS
cord-277417-f71jwdzj	12	27	,	,	,
cord-277417-f71jwdzj	12	28	continues	continue	VBZ
cord-277417-f71jwdzj	12	29	to	to	TO
cord-277417-f71jwdzj	12	30	be	be	VB
cord-277417-f71jwdzj	12	31	contentious	contentious	JJ
cord-277417-f71jwdzj	12	32	.	.	.
cord-277417-f71jwdzj	13	1	Will	Will	MD
cord-277417-f71jwdzj	13	2	a	a	DT
cord-277417-f71jwdzj	13	3	virus	virus	NN
cord-277417-f71jwdzj	13	4	become	become	VB
cord-277417-f71jwdzj	13	5	more	more	RBR
cord-277417-f71jwdzj	13	6	or	or	CC
cord-277417-f71jwdzj	13	7	less	less	RBR
cord-277417-f71jwdzj	13	8	virulent	virulent	JJ
cord-277417-f71jwdzj	13	9	in	in	IN
cord-277417-f71jwdzj	13	10	a	a	DT
cord-277417-f71jwdzj	13	11	new	new	JJ
cord-277417-f71jwdzj	13	12	host	host	NN
cord-277417-f71jwdzj	13	13	?	?	.
cord-277417-f71jwdzj	14	1	What	what	WDT
cord-277417-f71jwdzj	14	2	level	level	NN
cord-277417-f71jwdzj	14	3	of	of	IN
cord-277417-f71jwdzj	14	4	virulence	virulence	NN
cord-277417-f71jwdzj	14	5	is	be	VBZ
cord-277417-f71jwdzj	14	6	optimized	optimize	VBN
cord-277417-f71jwdzj	14	7	by	by	IN
cord-277417-f71jwdzj	14	8	natural	natural	JJ
cord-277417-f71jwdzj	14	9	selection	selection	NN
cord-277417-f71jwdzj	14	10	and	and	CC
cord-277417-f71jwdzj	14	11	why	why	WRB
cord-277417-f71jwdzj	14	12	?	?	.
cord-277417-f71jwdzj	15	1	Is	be	VBZ
cord-277417-f71jwdzj	15	2	there	there	EX
cord-277417-f71jwdzj	15	3	any	any	DT
cord-277417-f71jwdzj	15	4	consistent	consistent	JJ
cord-277417-f71jwdzj	15	5	association	association	NN
cord-277417-f71jwdzj	15	6	between	between	IN
cord-277417-f71jwdzj	15	7	host	host	NN
cord-277417-f71jwdzj	15	8	-	-	HYPH
cord-277417-f71jwdzj	15	9	jumping	jumping	NN
cord-277417-f71jwdzj	15	10	and	and	CC
cord-277417-f71jwdzj	15	11	virulence	virulence	NN
cord-277417-f71jwdzj	15	12	such	such	JJ
cord-277417-f71jwdzj	15	13	that	that	IN
cord-277417-f71jwdzj	15	14	predictions	prediction	NNS
cord-277417-f71jwdzj	15	15	can	can	MD
cord-277417-f71jwdzj	15	16	be	be	VB
cord-277417-f71jwdzj	15	17	made	make	VBN
cord-277417-f71jwdzj	15	18	about	about	IN
cord-277417-f71jwdzj	15	19	how	how	WRB
cord-277417-f71jwdzj	15	20	virulence	virulence	NN
cord-277417-f71jwdzj	15	21	might	may	MD
cord-277417-f71jwdzj	15	22	evolve	evolve	VB
cord-277417-f71jwdzj	15	23	following	follow	VBG
cord-277417-f71jwdzj	15	24	emergence	emergence	NN
cord-277417-f71jwdzj	15	25	?	?	.
cord-277417-f71jwdzj	16	1	Not	not	RB
cord-277417-f71jwdzj	16	2	only	only	RB
cord-277417-f71jwdzj	16	3	will	will	MD
cord-277417-f71jwdzj	16	4	the	the	DT
cord-277417-f71jwdzj	16	5	answers	answer	NNS
cord-277417-f71jwdzj	16	6	to	to	IN
cord-277417-f71jwdzj	16	7	these	these	DT
cord-277417-f71jwdzj	16	8	questions	question	NNS
cord-277417-f71jwdzj	16	9	reveal	reveal	VB
cord-277417-f71jwdzj	16	10	fundamental	fundamental	JJ
cord-277417-f71jwdzj	16	11	aspects	aspect	NNS
cord-277417-f71jwdzj	16	12	of	of	IN
cord-277417-f71jwdzj	16	13	virus	virus	NN
cord-277417-f71jwdzj	16	14	biology	biology	NN
cord-277417-f71jwdzj	16	15	,	,	,
cord-277417-f71jwdzj	16	16	but	but	CC
cord-277417-f71jwdzj	16	17	they	-PRON-	PRP
cord-277417-f71jwdzj	16	18	also	also	RB
cord-277417-f71jwdzj	16	19	may	may	MD
cord-277417-f71jwdzj	16	20	assist	assist	VB
cord-277417-f71jwdzj	16	21	in	in	IN
cord-277417-f71jwdzj	16	22	infectious	infectious	JJ
cord-277417-f71jwdzj	16	23	disease	disease	NN
cord-277417-f71jwdzj	16	24	management	management	NN
cord-277417-f71jwdzj	16	25	and	and	CC
cord-277417-f71jwdzj	16	26	mitigation	mitigation	NN
cord-277417-f71jwdzj	16	27	,	,	,
cord-277417-f71jwdzj	16	28	particularly	particularly	RB
cord-277417-f71jwdzj	16	29	as	as	IN
cord-277417-f71jwdzj	16	30	humans	human	NNS
cord-277417-f71jwdzj	16	31	,	,	,
cord-277417-f71jwdzj	16	32	other	other	JJ
cord-277417-f71jwdzj	16	33	animals	animal	NNS
cord-277417-f71jwdzj	16	34	and	and	CC
cord-277417-f71jwdzj	16	35	plants	plant	NNS
cord-277417-f71jwdzj	16	36	face	face	VBP
cord-277417-f71jwdzj	16	37	a	a	DT
cord-277417-f71jwdzj	16	38	continual	continual	JJ
cord-277417-f71jwdzj	16	39	threat	threat	NN
cord-277417-f71jwdzj	16	40	from	from	IN
cord-277417-f71jwdzj	16	41	emerging	emerge	VBG
cord-277417-f71jwdzj	16	42	viruses	virus	NNS
cord-277417-f71jwdzj	16	43	.	.	.
cord-277417-f71jwdzj	17	1	The	the	DT
cord-277417-f71jwdzj	17	2	term	term	NN
cord-277417-f71jwdzj	17	3	'	'	``
cord-277417-f71jwdzj	17	4	virulence	virulence	NN
cord-277417-f71jwdzj	17	5	'	'	''
cord-277417-f71jwdzj	17	6	has	have	VBZ
cord-277417-f71jwdzj	17	7	different	different	JJ
cord-277417-f71jwdzj	17	8	meanings	meaning	NNS
cord-277417-f71jwdzj	17	9	depending	depend	VBG
cord-277417-f71jwdzj	17	10	on	on	IN
cord-277417-f71jwdzj	17	11	context	context	NN
cord-277417-f71jwdzj	17	12	,	,	,
cord-277417-f71jwdzj	17	13	can	can	MD
cord-277417-f71jwdzj	17	14	be	be	VB
cord-277417-f71jwdzj	17	15	assessed	assess	VBN
cord-277417-f71jwdzj	17	16	in	in	IN
cord-277417-f71jwdzj	17	17	a	a	DT
cord-277417-f71jwdzj	17	18	variety	variety	NN
cord-277417-f71jwdzj	17	19	of	of	IN
cord-277417-f71jwdzj	17	20	ways	way	NNS
cord-277417-f71jwdzj	17	21	and	and	CC
cord-277417-f71jwdzj	17	22	is	be	VBZ
cord-277417-f71jwdzj	17	23	often	often	RB
cord-277417-f71jwdzj	17	24	only	only	RB
cord-277417-f71jwdzj	17	25	an	an	DT
cord-277417-f71jwdzj	17	26	operational	operational	JJ
cord-277417-f71jwdzj	17	27	measure	measure	NN
cord-277417-f71jwdzj	17	28	1	1	CD
cord-277417-f71jwdzj	17	29	.	.	.
cord-277417-f71jwdzj	18	1	To	to	TO
cord-277417-f71jwdzj	18	2	be	be	VB
cord-277417-f71jwdzj	18	3	as	as	RB
cord-277417-f71jwdzj	18	4	general	general	JJ
cord-277417-f71jwdzj	18	5	as	as	IN
cord-277417-f71jwdzj	18	6	possible	possible	JJ
cord-277417-f71jwdzj	18	7	,	,	,
cord-277417-f71jwdzj	18	8	we	-PRON-	PRP
cord-277417-f71jwdzj	18	9	assume	assume	VBP
cord-277417-f71jwdzj	18	10	a	a	DT
cord-277417-f71jwdzj	18	11	simple	simple	JJ
cord-277417-f71jwdzj	18	12	working	work	VBG
cord-277417-f71jwdzj	18	13	definition	definition	NN
cord-277417-f71jwdzj	18	14	of	of	IN
cord-277417-f71jwdzj	18	15	virulence	virulence	NN
cord-277417-f71jwdzj	18	16	:	:	:
cord-277417-f71jwdzj	18	17	the	the	DT
cord-277417-f71jwdzj	18	18	harm	harm	NN
cord-277417-f71jwdzj	18	19	caused	cause	VBN
cord-277417-f71jwdzj	18	20	by	by	IN
cord-277417-f71jwdzj	18	21	pathogen	pathogen	NN
cord-277417-f71jwdzj	18	22	infection	infection	NN
cord-277417-f71jwdzj	18	23	,	,	,
cord-277417-f71jwdzj	18	24	particularly	particularly	RB
cord-277417-f71jwdzj	18	25	in	in	IN
cord-277417-f71jwdzj	18	26	terms	term	NNS
cord-277417-f71jwdzj	18	27	of	of	IN
cord-277417-f71jwdzj	18	28	host	host	NN
cord-277417-f71jwdzj	18	29	morbidity	morbidity	NN
cord-277417-f71jwdzj	18	30	and	and	CC
cord-277417-f71jwdzj	18	31	mortality	mortality	NN
cord-277417-f71jwdzj	18	32	.	.	.
cord-277417-f71jwdzj	19	1	Virulence	virulence	NN
cord-277417-f71jwdzj	19	2	is	be	VBZ
cord-277417-f71jwdzj	19	3	also	also	RB
cord-277417-f71jwdzj	19	4	a	a	DT
cord-277417-f71jwdzj	19	5	complex	complex	JJ
cord-277417-f71jwdzj	19	6	trait	trait	NN
cord-277417-f71jwdzj	19	7	determined	determine	VBN
cord-277417-f71jwdzj	19	8	by	by	IN
cord-277417-f71jwdzj	19	9	a	a	DT
cord-277417-f71jwdzj	19	10	combination	combination	NN
cord-277417-f71jwdzj	19	11	of	of	IN
cord-277417-f71jwdzj	19	12	pathogen	pathogen	NN
cord-277417-f71jwdzj	19	13	,	,	,
cord-277417-f71jwdzj	19	14	host	host	NN
cord-277417-f71jwdzj	19	15	and	and	CC
cord-277417-f71jwdzj	19	16	environmental	environmental	JJ
cord-277417-f71jwdzj	19	17	factors	factor	NNS
cord-277417-f71jwdzj	19	18	.	.	.
cord-277417-f71jwdzj	20	1	Although	although	IN
cord-277417-f71jwdzj	20	2	it	-PRON-	PRP
cord-277417-f71jwdzj	20	3	is	be	VBZ
cord-277417-f71jwdzj	20	4	obviously	obviously	RB
cord-277417-f71jwdzj	20	5	necessary	necessary	JJ
cord-277417-f71jwdzj	20	6	to	to	TO
cord-277417-f71jwdzj	20	7	understand	understand	VB
cord-277417-f71jwdzj	20	8	all	all	DT
cord-277417-f71jwdzj	20	9	three	three	CD
cord-277417-f71jwdzj	20	10	,	,	,
cord-277417-f71jwdzj	20	11	we	-PRON-	PRP
cord-277417-f71jwdzj	20	12	focus	focus	VBP
cord-277417-f71jwdzj	20	13	on	on	IN
cord-277417-f71jwdzj	20	14	the	the	DT
cord-277417-f71jwdzj	20	15	pathogen	pathogen	NN
cord-277417-f71jwdzj	20	16	(	(	-LRB-
cord-277417-f71jwdzj	20	17	virus	virus	NN
cord-277417-f71jwdzj	20	18	)	)	-RRB-
cord-277417-f71jwdzj	20	19	component	component	NN
cord-277417-f71jwdzj	20	20	as	as	IN
cord-277417-f71jwdzj	20	21	this	this	DT
cord-277417-f71jwdzj	20	22	is	be	VBZ
cord-277417-f71jwdzj	20	23	the	the	DT
cord-277417-f71jwdzj	20	24	most	most	RBS
cord-277417-f71jwdzj	20	25	tractable	tractable	JJ
cord-277417-f71jwdzj	20	26	,	,	,
cord-277417-f71jwdzj	20	27	with	with	IN
cord-277417-f71jwdzj	20	28	the	the	DT
cord-277417-f71jwdzj	20	29	small	small	JJ
cord-277417-f71jwdzj	20	30	genomes	genome	NNS
cord-277417-f71jwdzj	20	31	and	and	CC
cord-277417-f71jwdzj	20	32	rapid	rapid	JJ
cord-277417-f71jwdzj	20	33	replication	replication	NN
cord-277417-f71jwdzj	20	34	and	and	CC
cord-277417-f71jwdzj	20	35	evolution	evolution	NN
cord-277417-f71jwdzj	20	36	of	of	IN
cord-277417-f71jwdzj	20	37	viruses	virus	NNS
cord-277417-f71jwdzj	20	38	facilitating	facilitate	VBG
cord-277417-f71jwdzj	20	39	comparative	comparative	JJ
cord-277417-f71jwdzj	20	40	and	and	CC
cord-277417-f71jwdzj	20	41	experimental	experimental	JJ
cord-277417-f71jwdzj	20	42	studies	study	NNS
cord-277417-f71jwdzj	20	43	,	,	,
cord-277417-f71jwdzj	20	44	and	and	CC
cord-277417-f71jwdzj	20	45	because	because	IN
cord-277417-f71jwdzj	20	46	there	there	EX
cord-277417-f71jwdzj	20	47	is	be	VBZ
cord-277417-f71jwdzj	20	48	strong	strong	JJ
cord-277417-f71jwdzj	20	49	evidence	evidence	NN
cord-277417-f71jwdzj	20	50	for	for	IN
cord-277417-f71jwdzj	20	51	heritable	heritable	JJ
cord-277417-f71jwdzj	20	52	virus	virus	NN
cord-277417-f71jwdzj	20	53	genetic	genetic	JJ
cord-277417-f71jwdzj	20	54	variation	variation	NN
cord-277417-f71jwdzj	20	55	for	for	IN
cord-277417-f71jwdzj	20	56	virulence	virulence	NN
cord-277417-f71jwdzj	20	57	2	2	CD
cord-277417-f71jwdzj	20	58	.	.	.
cord-277417-f71jwdzj	21	1	Although	although	IN
cord-277417-f71jwdzj	21	2	we	-PRON-	PRP
cord-277417-f71jwdzj	21	3	purposely	purposely	RB
cord-277417-f71jwdzj	21	4	focus	focus	VBP
cord-277417-f71jwdzj	21	5	on	on	IN
cord-277417-f71jwdzj	21	6	the	the	DT
cord-277417-f71jwdzj	21	7	analysis	analysis	NN
cord-277417-f71jwdzj	21	8	of	of	IN
cord-277417-f71jwdzj	21	9	virus	virus	NN
cord-277417-f71jwdzj	21	10	genomes	genome	NNS
cord-277417-f71jwdzj	21	11	,	,	,
cord-277417-f71jwdzj	21	12	genome	genome	NN
cord-277417-f71jwdzj	21	13	-	-	HYPH
cord-277417-f71jwdzj	21	14	wide	wide	JJ
cord-277417-f71jwdzj	21	15	association	association	NN
cord-277417-f71jwdzj	21	16	studies	study	NNS
cord-277417-f71jwdzj	21	17	(	(	-LRB-
cord-277417-f71jwdzj	21	18	GWAS	GWAS	NNP
cord-277417-f71jwdzj	21	19	)	)	-RRB-
cord-277417-f71jwdzj	21	20	promise	promise	VBP
cord-277417-f71jwdzj	21	21	to	to	TO
cord-277417-f71jwdzj	21	22	open	open	VB
cord-277417-f71jwdzj	21	23	up	up	RP
cord-277417-f71jwdzj	21	24	new	new	JJ
cord-277417-f71jwdzj	21	25	ways	way	NNS
cord-277417-f71jwdzj	21	26	to	to	TO
cord-277417-f71jwdzj	21	27	explore	explore	VB
cord-277417-f71jwdzj	21	28	the	the	DT
cord-277417-f71jwdzj	21	29	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	21	30	impact	impact	NN
cord-277417-f71jwdzj	21	31	of	of	IN
cord-277417-f71jwdzj	21	32	viral	viral	JJ
cord-277417-f71jwdzj	21	33	infections	infection	NNS
cord-277417-f71jwdzj	21	34	on	on	IN
cord-277417-f71jwdzj	21	35	host	host	NN
cord-277417-f71jwdzj	21	36	genomes	genome	NNS
cord-277417-f71jwdzj	21	37	3	3	CD
cord-277417-f71jwdzj	21	38	and	and	CC
cord-277417-f71jwdzj	21	39	hence	hence	RB
cord-277417-f71jwdzj	21	40	the	the	DT
cord-277417-f71jwdzj	21	41	intimate	intimate	JJ
cord-277417-f71jwdzj	21	42	interaction	interaction	NN
cord-277417-f71jwdzj	21	43	between	between	IN
cord-277417-f71jwdzj	21	44	host	host	NN
cord-277417-f71jwdzj	21	45	and	and	CC
cord-277417-f71jwdzj	21	46	virus	virus	NN
cord-277417-f71jwdzj	21	47	4	4	CD
cord-277417-f71jwdzj	21	48	.	.	.
cord-277417-f71jwdzj	22	1	Another	another	DT
cord-277417-f71jwdzj	22	2	complexity	complexity	NN
cord-277417-f71jwdzj	22	3	in	in	IN
cord-277417-f71jwdzj	22	4	studies	study	NNS
cord-277417-f71jwdzj	22	5	of	of	IN
cord-277417-f71jwdzj	22	6	virulence	virulence	NN
cord-277417-f71jwdzj	22	7	evolution	evolution	NN
cord-277417-f71jwdzj	22	8	is	be	VBZ
cord-277417-f71jwdzj	22	9	that	that	IN
cord-277417-f71jwdzj	22	10	metagenomics	metagenomics	NN
cord-277417-f71jwdzj	22	11	is	be	VBZ
cord-277417-f71jwdzj	22	12	increasingly	increasingly	RB
cord-277417-f71jwdzj	22	13	showing	show	VBG
cord-277417-f71jwdzj	22	14	that	that	IN
cord-277417-f71jwdzj	22	15	mixed	mixed	JJ
cord-277417-f71jwdzj	22	16	(	(	-LRB-
cord-277417-f71jwdzj	22	17	that	that	RB
cord-277417-f71jwdzj	22	18	is	is	RB
cord-277417-f71jwdzj	22	19	,	,	,
cord-277417-f71jwdzj	22	20	polymicrobial	polymicrobial	JJ
cord-277417-f71jwdzj	22	21	)	)	-RRB-
cord-277417-f71jwdzj	22	22	infections	infection	NNS
cord-277417-f71jwdzj	22	23	are	be	VBP
cord-277417-f71jwdzj	22	24	commonplace	commonplace	JJ
cord-277417-f71jwdzj	22	25	5	5	CD
cord-277417-f71jwdzj	22	26	,	,	,
cord-277417-f71jwdzj	22	27	and	and	CC
cord-277417-f71jwdzj	22	28	even	even	RB
cord-277417-f71jwdzj	22	29	seemingly	seemingly	RB
cord-277417-f71jwdzj	22	30	healthy	healthy	JJ
cord-277417-f71jwdzj	22	31	hosts	host	NNS
cord-277417-f71jwdzj	22	32	can	can	MD
cord-277417-f71jwdzj	22	33	carry	carry	VB
cord-277417-f71jwdzj	22	34	multiple	multiple	JJ
cord-277417-f71jwdzj	22	35	microorganisms	microorganism	NNS
cord-277417-f71jwdzj	22	36	of	of	IN
cord-277417-f71jwdzj	22	37	the	the	DT
cord-277417-f71jwdzj	22	38	kind	kind	NN
cord-277417-f71jwdzj	22	39	often	often	RB
cord-277417-f71jwdzj	22	40	thought	think	VBD
cord-277417-f71jwdzj	22	41	to	to	TO
cord-277417-f71jwdzj	22	42	be	be	VB
cord-277417-f71jwdzj	22	43	pathogenic	pathogenic	JJ
cord-277417-f71jwdzj	22	44	6	6	CD
cord-277417-f71jwdzj	22	45	,	,	,
cord-277417-f71jwdzj	22	46	7	7	CD
cord-277417-f71jwdzj	22	47	.	.	.
cord-277417-f71jwdzj	23	1	Determining	determine	VBG
cord-277417-f71jwdzj	23	2	which	which	WDT
cord-277417-f71jwdzj	23	3	microorganism	microorganism	NN
cord-277417-f71jwdzj	23	4	is	be	VBZ
cord-277417-f71jwdzj	23	5	the	the	DT
cord-277417-f71jwdzj	23	6	cause	cause	NN
cord-277417-f71jwdzj	23	7	of	of	IN
cord-277417-f71jwdzj	23	8	a	a	DT
cord-277417-f71jwdzj	23	9	particular	particular	JJ
cord-277417-f71jwdzj	23	10	disease	disease	NN
cord-277417-f71jwdzj	23	11	syndrome	syndrome	NN
cord-277417-f71jwdzj	23	12	can	can	MD
cord-277417-f71jwdzj	23	13	be	be	VB
cord-277417-f71jwdzj	23	14	troublesome	troublesome	JJ
cord-277417-f71jwdzj	23	15	,	,	,
cord-277417-f71jwdzj	23	16	and	and	CC
cord-277417-f71jwdzj	23	17	it	-PRON-	PRP
cord-277417-f71jwdzj	23	18	is	be	VBZ
cord-277417-f71jwdzj	23	19	possible	possible	JJ
cord-277417-f71jwdzj	23	20	that	that	IN
cord-277417-f71jwdzj	23	21	overt	overt	JJ
cord-277417-f71jwdzj	23	22	illness	illness	NN
cord-277417-f71jwdzj	23	23	might	may	MD
cord-277417-f71jwdzj	23	24	result	result	VB
cord-277417-f71jwdzj	23	25	from	from	IN
cord-277417-f71jwdzj	23	26	synergistic	synergistic	JJ
cord-277417-f71jwdzj	23	27	interactions	interaction	NNS
cord-277417-f71jwdzj	23	28	between	between	IN
cord-277417-f71jwdzj	23	29	multiple	multiple	JJ
cord-277417-f71jwdzj	23	30	microorganisms	microorganism	NNS
cord-277417-f71jwdzj	23	31	that	that	WDT
cord-277417-f71jwdzj	23	32	overwhelm	overwhelm	VBP
cord-277417-f71jwdzj	23	33	the	the	DT
cord-277417-f71jwdzj	23	34	host	host	NN
cord-277417-f71jwdzj	23	35	.	.	.
cord-277417-f71jwdzj	24	1	Hence	hence	RB
cord-277417-f71jwdzj	24	2	,	,	,
cord-277417-f71jwdzj	24	3	the	the	DT
cord-277417-f71jwdzj	24	4	model	model	NN
cord-277417-f71jwdzj	24	5	of	of	IN
cord-277417-f71jwdzj	24	6	one	one	CD
cord-277417-f71jwdzj	24	7	pathogen	pathogen	NN
cord-277417-f71jwdzj	24	8	-	-	HYPH
cord-277417-f71jwdzj	24	9	one	one	CD
cord-277417-f71jwdzj	24	10	disease	disease	NN
cord-277417-f71jwdzj	24	11	that	that	WDT
cord-277417-f71jwdzj	24	12	has	have	VBZ
cord-277417-f71jwdzj	24	13	dominated	dominate	VBN
cord-277417-f71jwdzj	24	14	studies	study	NNS
cord-277417-f71jwdzj	24	15	of	of	IN
cord-277417-f71jwdzj	24	16	human	human	JJ
cord-277417-f71jwdzj	24	17	infections	infection	NNS
cord-277417-f71jwdzj	24	18	,	,	,
cord-277417-f71jwdzj	24	19	and	and	CC
cord-277417-f71jwdzj	24	20	implicitly	implicitly	RB
cord-277417-f71jwdzj	24	21	models	model	NNS
cord-277417-f71jwdzj	24	22	of	of	IN
cord-277417-f71jwdzj	24	23	virulence	virulence	NN
cord-277417-f71jwdzj	24	24	evolution	evolution	NN
cord-277417-f71jwdzj	24	25	,	,	,
cord-277417-f71jwdzj	24	26	may	may	MD
cord-277417-f71jwdzj	24	27	be	be	VB
cord-277417-f71jwdzj	24	28	overly	overly	RB
cord-277417-f71jwdzj	24	29	simplistic	simplistic	JJ
cord-277417-f71jwdzj	24	30	.	.	.
cord-277417-f71jwdzj	25	1	It	-PRON-	PRP
cord-277417-f71jwdzj	25	2	is	be	VBZ
cord-277417-f71jwdzj	25	3	also	also	RB
cord-277417-f71jwdzj	25	4	possible	possible	JJ
cord-277417-f71jwdzj	25	5	that	that	IN
cord-277417-f71jwdzj	25	6	measurements	measurement	NNS
cord-277417-f71jwdzj	25	7	of	of	IN
cord-277417-f71jwdzj	25	8	relative	relative	JJ
cord-277417-f71jwdzj	25	9	virulence	virulence	NN
cord-277417-f71jwdzj	25	10	vary	vary	VBP
cord-277417-f71jwdzj	25	11	between	between	IN
cord-277417-f71jwdzj	25	12	humans	human	NNS
cord-277417-f71jwdzj	25	13	and	and	CC
cord-277417-f71jwdzj	25	14	wildlife	wildlife	NN
cord-277417-f71jwdzj	25	15	populations	population	NNS
cord-277417-f71jwdzj	25	16	.	.	.
cord-277417-f71jwdzj	26	1	For	for	IN
cord-277417-f71jwdzj	26	2	example	example	NN
cord-277417-f71jwdzj	26	3	,	,	,
cord-277417-f71jwdzj	26	4	whereas	whereas	IN
cord-277417-f71jwdzj	26	5	dengue	dengue	NN
cord-277417-f71jwdzj	26	6	is	be	VBZ
cord-277417-f71jwdzj	26	7	considered	consider	VBN
cord-277417-f71jwdzj	26	8	an	an	DT
cord-277417-f71jwdzj	26	9	important	important	JJ
cord-277417-f71jwdzj	26	10	infectious	infectious	JJ
cord-277417-f71jwdzj	26	11	disease	disease	NN
cord-277417-f71jwdzj	26	12	of	of	IN
cord-277417-f71jwdzj	26	13	humans	human	NNS
cord-277417-f71jwdzj	26	14	,	,	,
cord-277417-f71jwdzj	26	15	the	the	DT
cord-277417-f71jwdzj	26	16	virulence	virulence	NN
cord-277417-f71jwdzj	26	17	of	of	IN
cord-277417-f71jwdzj	26	18	dengue	dengue	NN
cord-277417-f71jwdzj	26	19	virus	virus	NN
cord-277417-f71jwdzj	26	20	is	be	VBZ
cord-277417-f71jwdzj	26	21	low	low	JJ
cord-277417-f71jwdzj	26	22	in	in	IN
cord-277417-f71jwdzj	26	23	terms	term	NNS
cord-277417-f71jwdzj	26	24	of	of	IN
cord-277417-f71jwdzj	26	25	overall	overall	JJ
cord-277417-f71jwdzj	26	26	mortality	mortality	NN
cord-277417-f71jwdzj	26	27	in	in	IN
cord-277417-f71jwdzj	26	28	humans	human	NNS
cord-277417-f71jwdzj	26	29	,	,	,
cord-277417-f71jwdzj	26	30	and	and	CC
cord-277417-f71jwdzj	26	31	infections	infection	NNS
cord-277417-f71jwdzj	26	32	of	of	IN
cord-277417-f71jwdzj	26	33	equivalent	equivalent	JJ
cord-277417-f71jwdzj	26	34	severity	severity	NN
cord-277417-f71jwdzj	26	35	may	may	MD
cord-277417-f71jwdzj	26	36	go	go	VB
cord-277417-f71jwdzj	26	37	unnoticed	unnoticed	JJ
cord-277417-f71jwdzj	26	38	in	in	IN
cord-277417-f71jwdzj	26	39	wildlife	wildlife	NN
cord-277417-f71jwdzj	26	40	,	,	,
cord-277417-f71jwdzj	26	41	particularly	particularly	RB
cord-277417-f71jwdzj	26	42	as	as	IN
cord-277417-f71jwdzj	26	43	there	there	EX
cord-277417-f71jwdzj	26	44	is	be	VBZ
cord-277417-f71jwdzj	26	45	a	a	DT
cord-277417-f71jwdzj	26	46	strong	strong	JJ
cord-277417-f71jwdzj	26	47	sampling	sampling	NN
cord-277417-f71jwdzj	26	48	bias	bias	NN
cord-277417-f71jwdzj	26	49	towards	towards	IN
cord-277417-f71jwdzj	26	50	the	the	DT
cord-277417-f71jwdzj	26	51	most	most	RBS
cord-277417-f71jwdzj	26	52	virulent	virulent	JJ
cord-277417-f71jwdzj	26	53	presentations	presentation	NNS
cord-277417-f71jwdzj	26	54	.	.	.
cord-277417-f71jwdzj	27	1	Virulence	virulence	NN
cord-277417-f71jwdzj	27	2	evolution	evolution	NN
cord-277417-f71jwdzj	27	3	in	in	IN
cord-277417-f71jwdzj	27	4	viruses	virus	NNS
cord-277417-f71jwdzj	27	5	has	have	VBZ
cord-277417-f71jwdzj	27	6	traditionally	traditionally	RB
cord-277417-f71jwdzj	27	7	been	be	VBN
cord-277417-f71jwdzj	27	8	studied	study	VBN
cord-277417-f71jwdzj	27	9	from	from	IN
cord-277417-f71jwdzj	27	10	one	one	CD
cord-277417-f71jwdzj	27	11	of	of	IN
cord-277417-f71jwdzj	27	12	two	two	CD
cord-277417-f71jwdzj	27	13	separate	separate	JJ
cord-277417-f71jwdzj	27	14	research	research	NN
cord-277417-f71jwdzj	27	15	paths	path	NNS
cord-277417-f71jwdzj	27	16	-the	-the	:
cord-277417-f71jwdzj	27	17	theoretical	theoretical	JJ
cord-277417-f71jwdzj	27	18	and	and	CC
cord-277417-f71jwdzj	27	19	the	the	DT
cord-277417-f71jwdzj	27	20	empirical	empirical	JJ
cord-277417-f71jwdzj	27	21	-that	-that	NN
cord-277417-f71jwdzj	27	22	have	have	VBP
cord-277417-f71jwdzj	27	23	largely	largely	RB
cord-277417-f71jwdzj	27	24	been	be	VBN
cord-277417-f71jwdzj	27	25	pursued	pursue	VBN
cord-277417-f71jwdzj	27	26	independently	independently	RB
cord-277417-f71jwdzj	27	27	.	.	.
cord-277417-f71jwdzj	28	1	Although	although	IN
cord-277417-f71jwdzj	28	2	theory	theory	NN
cord-277417-f71jwdzj	28	3	and	and	CC
cord-277417-f71jwdzj	28	4	empiricism	empiricism	NN
cord-277417-f71jwdzj	28	5	have	have	VBP
cord-277417-f71jwdzj	28	6	each	each	DT
cord-277417-f71jwdzj	28	7	generated	generate	VBN
cord-277417-f71jwdzj	28	8	important	important	JJ
cord-277417-f71jwdzj	28	9	and	and	CC
cord-277417-f71jwdzj	28	10	parallel	parallel	JJ
cord-277417-f71jwdzj	28	11	insights	insight	NNS
cord-277417-f71jwdzj	28	12	,	,	,
cord-277417-f71jwdzj	28	13	they	-PRON-	PRP
cord-277417-f71jwdzj	28	14	have	have	VBP
cord-277417-f71jwdzj	28	15	each	each	DT
cord-277417-f71jwdzj	28	16	been	be	VBN
cord-277417-f71jwdzj	28	17	able	able	JJ
cord-277417-f71jwdzj	28	18	to	to	TO
cord-277417-f71jwdzj	28	19	paint	paint	VB
cord-277417-f71jwdzj	28	20	only	only	RB
cord-277417-f71jwdzj	28	21	a	a	DT
cord-277417-f71jwdzj	28	22	partial	partial	JJ
cord-277417-f71jwdzj	28	23	picture	picture	NN
cord-277417-f71jwdzj	28	24	of	of	IN
cord-277417-f71jwdzj	28	25	virulence	virulence	NN
cord-277417-f71jwdzj	28	26	evolution	evolution	NN
cord-277417-f71jwdzj	28	27	.	.	.
cord-277417-f71jwdzj	29	1	Few	few	JJ
cord-277417-f71jwdzj	29	2	attempts	attempt	NNS
cord-277417-f71jwdzj	29	3	have	have	VBP
cord-277417-f71jwdzj	29	4	been	be	VBN
cord-277417-f71jwdzj	29	5	made	make	VBN
cord-277417-f71jwdzj	29	6	to	to	TO
cord-277417-f71jwdzj	29	7	bridge	bridge	VB
cord-277417-f71jwdzj	29	8	this	this	DT
cord-277417-f71jwdzj	29	9	divide	divide	NN
cord-277417-f71jwdzj	29	10	8,9	8,9	CD
cord-277417-f71jwdzj	29	11	.	.	.
cord-277417-f71jwdzj	30	1	There	there	EX
cord-277417-f71jwdzj	30	2	is	be	VBZ
cord-277417-f71jwdzj	30	3	now	now	RB
cord-277417-f71jwdzj	30	4	a	a	DT
cord-277417-f71jwdzj	30	5	large	large	JJ
cord-277417-f71jwdzj	30	6	body	body	NN
cord-277417-f71jwdzj	30	7	of	of	IN
cord-277417-f71jwdzj	30	8	long	long	RB
cord-277417-f71jwdzj	30	9	-	-	HYPH
cord-277417-f71jwdzj	30	10	standing	stand	VBG
cord-277417-f71jwdzj	30	11	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	30	12	theory	theory	NN
cord-277417-f71jwdzj	30	13	that	that	WDT
cord-277417-f71jwdzj	30	14	considers	consider	VBZ
cord-277417-f71jwdzj	30	15	what	what	WDT
cord-277417-f71jwdzj	30	16	level	level	NN
cord-277417-f71jwdzj	30	17	of	of	IN
cord-277417-f71jwdzj	30	18	virulence	virulence	NN
cord-277417-f71jwdzj	30	19	maximizes	maximize	VBZ
cord-277417-f71jwdzj	30	20	pathogen	pathogen	NN
cord-277417-f71jwdzj	30	21	fitness	fitness	NN
cord-277417-f71jwdzj	30	22	under	under	IN
cord-277417-f71jwdzj	30	23	variable	variable	JJ
cord-277417-f71jwdzj	30	24	conditions	condition	NNS
cord-277417-f71jwdzj	30	25	,	,	,
cord-277417-f71jwdzj	30	26	such	such	JJ
cord-277417-f71jwdzj	30	27	as	as	IN
cord-277417-f71jwdzj	30	28	differing	differ	VBG
cord-277417-f71jwdzj	30	29	modes	mode	NNS
cord-277417-f71jwdzj	30	30	of	of	IN
cord-277417-f71jwdzj	30	31	transmission	transmission	NN
cord-277417-f71jwdzj	30	32	,	,	,
cord-277417-f71jwdzj	30	33	levels	level	NNS
cord-277417-f71jwdzj	30	34	of	of	IN
cord-277417-f71jwdzj	30	35	co	co	NN
cord-277417-f71jwdzj	30	36	-	-	NN
cord-277417-f71jwdzj	30	37	infection	infection	NN
cord-277417-f71jwdzj	30	38	,	,	,
cord-277417-f71jwdzj	30	39	selection	selection	NN
cord-277417-f71jwdzj	30	40	pressures	pressure	NNS
cord-277417-f71jwdzj	30	41	,	,	,
cord-277417-f71jwdzj	30	42	and	and	CC
cord-277417-f71jwdzj	30	43	both	both	DT
cord-277417-f71jwdzj	30	44	within	within	IN
cord-277417-f71jwdzj	30	45	and	and	CC
cord-277417-f71jwdzj	30	46	between	between	IN
cord-277417-f71jwdzj	30	47	hosts	host	NNS
cord-277417-f71jwdzj	30	48	10	10	CD
cord-277417-f71jwdzj	30	49	.	.	.
cord-277417-f71jwdzj	31	1	Although	although	IN
cord-277417-f71jwdzj	31	2	of	of	IN
cord-277417-f71jwdzj	31	3	great	great	JJ
cord-277417-f71jwdzj	31	4	value	value	NN
cord-277417-f71jwdzj	31	5	,	,	,
cord-277417-f71jwdzj	31	6	a	a	DT
cord-277417-f71jwdzj	31	7	drawback	drawback	NN
cord-277417-f71jwdzj	31	8	is	be	VBZ
cord-277417-f71jwdzj	31	9	that	that	IN
cord-277417-f71jwdzj	31	10	this	this	DT
cord-277417-f71jwdzj	31	11	work	work	NN
cord-277417-f71jwdzj	31	12	is	be	VBZ
cord-277417-f71jwdzj	31	13	unavoidably	unavoidably	RB
cord-277417-f71jwdzj	31	14	based	base	VBN
cord-277417-f71jwdzj	31	15	on	on	IN
cord-277417-f71jwdzj	31	16	a	a	DT
cord-277417-f71jwdzj	31	17	small	small	JJ
cord-277417-f71jwdzj	31	18	number	number	NN
cord-277417-f71jwdzj	31	19	of	of	IN
cord-277417-f71jwdzj	31	20	case	case	NN
cord-277417-f71jwdzj	31	21	studies	study	NNS
cord-277417-f71jwdzj	31	22	,	,	,
cord-277417-f71jwdzj	31	23	the	the	DT
cord-277417-f71jwdzj	31	24	most	most	RBS
cord-277417-f71jwdzj	31	25	famous	famous	JJ
cord-277417-f71jwdzj	31	26	of	of	IN
cord-277417-f71jwdzj	31	27	which	which	WDT
cord-277417-f71jwdzj	31	28	is	be	VBZ
cord-277417-f71jwdzj	31	29	the	the	DT
cord-277417-f71jwdzj	31	30	co	co	NN
cord-277417-f71jwdzj	31	31	-	-	NN
cord-277417-f71jwdzj	31	32	evolution	evolution	NN
cord-277417-f71jwdzj	31	33	of	of	IN
cord-277417-f71jwdzj	31	34	myxoma	myxoma	NNP
cord-277417-f71jwdzj	31	35	virus	virus	NN
cord-277417-f71jwdzj	31	36	(	(	-LRB-
cord-277417-f71jwdzj	31	37	MYXV	MYXV	NNP
cord-277417-f71jwdzj	31	38	)	)	-RRB-
cord-277417-f71jwdzj	31	39	and	and	CC
cord-277417-f71jwdzj	31	40	European	european	JJ
cord-277417-f71jwdzj	31	41	rabbits	rabbit	NNS
cord-277417-f71jwdzj	31	42	following	follow	VBG
cord-277417-f71jwdzj	31	43	the	the	DT
cord-277417-f71jwdzj	31	44	release	release	NN
cord-277417-f71jwdzj	31	45	of	of	IN
cord-277417-f71jwdzj	31	46	MYXV	MYXV	NNP
cord-277417-f71jwdzj	31	47	as	as	IN
cord-277417-f71jwdzj	31	48	a	a	DT
cord-277417-f71jwdzj	31	49	biological	biological	JJ
cord-277417-f71jwdzj	31	50	control	control	NN
cord-277417-f71jwdzj	31	51	11	11	CD
cord-277417-f71jwdzj	31	52	.	.	.
cord-277417-f71jwdzj	32	1	However	however	RB
cord-277417-f71jwdzj	32	2	,	,	,
cord-277417-f71jwdzj	32	3	the	the	DT
cord-277417-f71jwdzj	32	4	insights	insight	NNS
cord-277417-f71jwdzj	32	5	Virulence	Virulence	NNP
cord-277417-f71jwdzj	32	6	Although	although	IN
cord-277417-f71jwdzj	32	7	virulence	virulence	NN
cord-277417-f71jwdzj	32	8	can	can	MD
cord-277417-f71jwdzj	32	9	be	be	VB
cord-277417-f71jwdzj	32	10	defined	define	VBN
cord-277417-f71jwdzj	32	11	in	in	IN
cord-277417-f71jwdzj	32	12	a	a	DT
cord-277417-f71jwdzj	32	13	range	range	NN
cord-277417-f71jwdzj	32	14	of	of	IN
cord-277417-f71jwdzj	32	15	casespecific	casespecific	NN
cord-277417-f71jwdzj	32	16	ways	way	NNS
cord-277417-f71jwdzj	32	17	,	,	,
cord-277417-f71jwdzj	32	18	the	the	DT
cord-277417-f71jwdzj	32	19	simplest	simple	JJS
cord-277417-f71jwdzj	32	20	definition	definition	NN
cord-277417-f71jwdzj	32	21	is	be	VBZ
cord-277417-f71jwdzj	32	22	the	the	DT
cord-277417-f71jwdzj	32	23	severity	severity	NN
cord-277417-f71jwdzj	32	24	or	or	CC
cord-277417-f71jwdzj	32	25	harmfulness	harmfulness	NN
cord-277417-f71jwdzj	32	26	of	of	IN
cord-277417-f71jwdzj	32	27	a	a	DT
cord-277417-f71jwdzj	32	28	pathogen	pathogen	NN
cord-277417-f71jwdzj	32	29	.	.	.
cord-277417-f71jwdzj	33	1	The	the	DT
cord-277417-f71jwdzj	33	2	study	study	NN
cord-277417-f71jwdzj	33	3	of	of	IN
cord-277417-f71jwdzj	33	4	genetic	genetic	JJ
cord-277417-f71jwdzj	33	5	material	material	NN
cord-277417-f71jwdzj	33	6	recovered	recover	VBN
cord-277417-f71jwdzj	33	7	from	from	IN
cord-277417-f71jwdzj	33	8	microbial	microbial	JJ
cord-277417-f71jwdzj	33	9	(	(	-LRB-
cord-277417-f71jwdzj	33	10	including	include	VBG
cord-277417-f71jwdzj	33	11	viral	viral	JJ
cord-277417-f71jwdzj	33	12	)	)	-RRB-
cord-277417-f71jwdzj	33	13	communities	community	NNS
cord-277417-f71jwdzj	33	14	in	in	IN
cord-277417-f71jwdzj	33	15	which	which	WDT
cord-277417-f71jwdzj	33	16	genome	genome	NN
cord-277417-f71jwdzj	33	17	sequence	sequence	NN
cord-277417-f71jwdzj	33	18	data	datum	NNS
cord-277417-f71jwdzj	33	19	are	be	VBP
cord-277417-f71jwdzj	33	20	simultaneously	simultaneously	RB
cord-277417-f71jwdzj	33	21	generated	generate	VBN
cord-277417-f71jwdzj	33	22	for	for	IN
cord-277417-f71jwdzj	33	23	all	all	PDT
cord-277417-f71jwdzj	33	24	the	the	DT
cord-277417-f71jwdzj	33	25	microorganisms	microorganism	NNS
cord-277417-f71jwdzj	33	26	present	present	JJ
cord-277417-f71jwdzj	33	27	.	.	.
cord-277417-f71jwdzj	34	1	The	the	DT
cord-277417-f71jwdzj	34	2	reduction	reduction	NN
cord-277417-f71jwdzj	34	3	in	in	IN
cord-277417-f71jwdzj	34	4	numbers	number	NNS
cord-277417-f71jwdzj	34	5	or	or	CC
cord-277417-f71jwdzj	34	6	elimination	elimination	NN
cord-277417-f71jwdzj	34	7	of	of	IN
cord-277417-f71jwdzj	34	8	pest	pest	NN
cord-277417-f71jwdzj	34	9	organisms	organism	NNS
cord-277417-f71jwdzj	34	10	through	through	IN
cord-277417-f71jwdzj	34	11	the	the	DT
cord-277417-f71jwdzj	34	12	introduction	introduction	NN
cord-277417-f71jwdzj	34	13	of	of	IN
cord-277417-f71jwdzj	34	14	a	a	DT
cord-277417-f71jwdzj	34	15	pathogen	pathogen	NN
cord-277417-f71jwdzj	34	16	.	.	.
cord-277417-f71jwdzj	35	1	from	from	IN
cord-277417-f71jwdzj	35	2	examples	example	NNS
cord-277417-f71jwdzj	35	3	such	such	JJ
cord-277417-f71jwdzj	35	4	as	as	IN
cord-277417-f71jwdzj	35	5	MYXV	MYXV	NNP
cord-277417-f71jwdzj	35	6	may	may	MD
cord-277417-f71jwdzj	35	7	be	be	VB
cord-277417-f71jwdzj	35	8	insufficient	insufficient	JJ
cord-277417-f71jwdzj	35	9	to	to	TO
cord-277417-f71jwdzj	35	10	adequately	adequately	RB
cord-277417-f71jwdzj	35	11	inform	inform	VB
cord-277417-f71jwdzj	35	12	theoretical	theoretical	JJ
cord-277417-f71jwdzj	35	13	models	model	NNS
cord-277417-f71jwdzj	35	14	confronted	confront	VBN
cord-277417-f71jwdzj	35	15	with	with	IN
cord-277417-f71jwdzj	35	16	novel	novel	JJ
cord-277417-f71jwdzj	35	17	,	,	,
cord-277417-f71jwdzj	35	18	real	real	JJ
cord-277417-f71jwdzj	35	19	-	-	HYPH
cord-277417-f71jwdzj	35	20	world	world	NN
cord-277417-f71jwdzj	35	21	emergence	emergence	NN
cord-277417-f71jwdzj	35	22	events	event	NNS
cord-277417-f71jwdzj	35	23	.	.	.
cord-277417-f71jwdzj	36	1	By	by	IN
cord-277417-f71jwdzj	36	2	contrast	contrast	NN
cord-277417-f71jwdzj	36	3	,	,	,
cord-277417-f71jwdzj	36	4	empirical	empirical	JJ
cord-277417-f71jwdzj	36	5	studies	study	NNS
cord-277417-f71jwdzj	36	6	involve	involve	VBP
cord-277417-f71jwdzj	36	7	laboratorybased	laboratorybase	VBN
cord-277417-f71jwdzj	36	8	methods	method	NNS
cord-277417-f71jwdzj	36	9	to	to	TO
cord-277417-f71jwdzj	36	10	identify	identify	VB
cord-277417-f71jwdzj	36	11	the	the	DT
cord-277417-f71jwdzj	36	12	mutations	mutation	NNS
cord-277417-f71jwdzj	36	13	that	that	WDT
cord-277417-f71jwdzj	36	14	affect	affect	VBP
cord-277417-f71jwdzj	36	15	virulence	virulence	NN
cord-277417-f71jwdzj	36	16	(	(	-LRB-
cord-277417-f71jwdzj	36	17	that	that	RB
cord-277417-f71jwdzj	36	18	is	is	RB
cord-277417-f71jwdzj	36	19	,	,	,
cord-277417-f71jwdzj	36	20	virulence	virulence	NN
cord-277417-f71jwdzj	36	21	determinants	determinant	NNS
cord-277417-f71jwdzj	36	22	)	)	-RRB-
cord-277417-f71jwdzj	36	23	,	,	,
cord-277417-f71jwdzj	36	24	usually	usually	RB
cord-277417-f71jwdzj	36	25	on	on	IN
cord-277417-f71jwdzj	36	26	the	the	DT
cord-277417-f71jwdzj	36	27	basis	basis	NN
cord-277417-f71jwdzj	36	28	of	of	IN
cord-277417-f71jwdzj	36	29	a	a	DT
cord-277417-f71jwdzj	36	30	combination	combination	NN
cord-277417-f71jwdzj	36	31	of	of	IN
cord-277417-f71jwdzj	36	32	reverse	reverse	JJ
cord-277417-f71jwdzj	36	33	genetics	genetic	NNS
cord-277417-f71jwdzj	36	34	and	and	CC
cord-277417-f71jwdzj	36	35	cell	cell	NN
cord-277417-f71jwdzj	36	36	culture	culture	NN
cord-277417-f71jwdzj	36	37	and/or	and/or	CC
cord-277417-f71jwdzj	36	38	animal	animal	NN
cord-277417-f71jwdzj	36	39	models	model	NNS
cord-277417-f71jwdzj	36	40	8	8	CD
cord-277417-f71jwdzj	36	41	,	,	,
cord-277417-f71jwdzj	36	42	9	9	CD
cord-277417-f71jwdzj	36	43	,	,	,
cord-277417-f71jwdzj	36	44	[	[	-LRB-
cord-277417-f71jwdzj	36	45	12	12	CD
cord-277417-f71jwdzj	36	46	]	]	-RRB-
cord-277417-f71jwdzj	36	47	[	[	-LRB-
cord-277417-f71jwdzj	36	48	13	13	CD
cord-277417-f71jwdzj	36	49	]	]	-RRB-
cord-277417-f71jwdzj	37	1	[	[	-LRB-
cord-277417-f71jwdzj	37	2	14	14	CD
cord-277417-f71jwdzj	37	3	]	]	-RRB-
cord-277417-f71jwdzj	37	4	[	[	-LRB-
cord-277417-f71jwdzj	37	5	15	15	CD
cord-277417-f71jwdzj	37	6	]	]	-RRB-
cord-277417-f71jwdzj	37	7	[	[	-LRB-
cord-277417-f71jwdzj	37	8	16	16	CD
cord-277417-f71jwdzj	37	9	]	]	-RRB-
cord-277417-f71jwdzj	37	10	.	.	.
cord-277417-f71jwdzj	38	1	These	these	DT
cord-277417-f71jwdzj	38	2	studies	study	NNS
cord-277417-f71jwdzj	38	3	are	be	VBP
cord-277417-f71jwdzj	38	4	often	often	RB
cord-277417-f71jwdzj	38	5	very	very	RB
cord-277417-f71jwdzj	38	6	successful	successful	JJ
cord-277417-f71jwdzj	38	7	in	in	IN
cord-277417-f71jwdzj	38	8	pinpointing	pinpoint	VBG
cord-277417-f71jwdzj	38	9	causal	causal	JJ
cord-277417-f71jwdzj	38	10	mutations	mutation	NNS
cord-277417-f71jwdzj	38	11	(	(	-LRB-
cord-277417-f71jwdzj	38	12	see	see	VB
cord-277417-f71jwdzj	38	13	are	be	VBP
cord-277417-f71jwdzj	38	14	not	not	RB
cord-277417-f71jwdzj	38	15	considered	consider	VBN
cord-277417-f71jwdzj	38	16	in	in	IN
cord-277417-f71jwdzj	38	17	an	an	DT
cord-277417-f71jwdzj	38	18	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	38	19	context	context	NN
cord-277417-f71jwdzj	38	20	,	,	,
cord-277417-f71jwdzj	38	21	their	-PRON-	PRP$
cord-277417-f71jwdzj	38	22	relevance	relevance	NN
cord-277417-f71jwdzj	38	23	for	for	IN
cord-277417-f71jwdzj	38	24	general	general	JJ
cord-277417-f71jwdzj	38	25	theories	theory	NNS
cord-277417-f71jwdzj	38	26	of	of	IN
cord-277417-f71jwdzj	38	27	virulence	virulence	NN
cord-277417-f71jwdzj	38	28	evolution	evolution	NN
cord-277417-f71jwdzj	38	29	is	be	VBZ
cord-277417-f71jwdzj	38	30	usually	usually	RB
cord-277417-f71jwdzj	38	31	ignored	ignore	VBN
cord-277417-f71jwdzj	38	32	.	.	.
cord-277417-f71jwdzj	39	1	In	in	IN
cord-277417-f71jwdzj	39	2	addition	addition	NN
cord-277417-f71jwdzj	39	3	,	,	,
cord-277417-f71jwdzj	39	4	in	in	IN
cord-277417-f71jwdzj	39	5	vitro	vitro	FW
cord-277417-f71jwdzj	39	6	methods	method	NNS
cord-277417-f71jwdzj	39	7	may	may	MD
cord-277417-f71jwdzj	39	8	not	not	RB
cord-277417-f71jwdzj	39	9	reflect	reflect	VB
cord-277417-f71jwdzj	39	10	real	real	JJ
cord-277417-f71jwdzj	39	11	-	-	HYPH
cord-277417-f71jwdzj	39	12	world	world	NN
cord-277417-f71jwdzj	39	13	selection	selection	NN
cord-277417-f71jwdzj	39	14	pressures	pressure	NNS
cord-277417-f71jwdzj	39	15	,	,	,
cord-277417-f71jwdzj	39	16	there	there	EX
cord-277417-f71jwdzj	39	17	may	may	MD
cord-277417-f71jwdzj	39	18	be	be	VB
cord-277417-f71jwdzj	39	19	little	little	JJ
cord-277417-f71jwdzj	39	20	consideration	consideration	NN
cord-277417-f71jwdzj	39	21	about	about	IN
cord-277417-f71jwdzj	39	22	how	how	WRB
cord-277417-f71jwdzj	39	23	virulence	virulence	NN
cord-277417-f71jwdzj	39	24	mutations	mutation	NNS
cord-277417-f71jwdzj	39	25	affect	affect	VBP
cord-277417-f71jwdzj	39	26	inter	inter	JJ
cord-277417-f71jwdzj	39	27	-	-	JJ
cord-277417-f71jwdzj	39	28	host	host	JJ
cord-277417-f71jwdzj	39	29	transmission	transmission	NN
cord-277417-f71jwdzj	39	30	,	,	,
cord-277417-f71jwdzj	39	31	and	and	CC
cord-277417-f71jwdzj	39	32	animal	animal	NN
cord-277417-f71jwdzj	39	33	models	model	NNS
cord-277417-f71jwdzj	39	34	commonly	commonly	RB
cord-277417-f71jwdzj	39	35	differ	differ	VBP
cord-277417-f71jwdzj	39	36	from	from	IN
cord-277417-f71jwdzj	39	37	the	the	DT
cord-277417-f71jwdzj	39	38	species	specie	NNS
cord-277417-f71jwdzj	39	39	infected	infect	VBN
cord-277417-f71jwdzj	39	40	in	in	IN
cord-277417-f71jwdzj	39	41	the	the	DT
cord-277417-f71jwdzj	39	42	field	field	NN
cord-277417-f71jwdzj	39	43	.	.	.
cord-277417-f71jwdzj	40	1	For	for	IN
cord-277417-f71jwdzj	40	2	example	example	NN
cord-277417-f71jwdzj	40	3	,	,	,
cord-277417-f71jwdzj	40	4	virulence	virulence	NN
cord-277417-f71jwdzj	40	5	determinants	determinant	NNS
cord-277417-f71jwdzj	40	6	in	in	IN
cord-277417-f71jwdzj	40	7	MYXV	MYXV	NNP
cord-277417-f71jwdzj	40	8	identified	identify	VBN
cord-277417-f71jwdzj	40	9	on	on	IN
cord-277417-f71jwdzj	40	10	the	the	DT
cord-277417-f71jwdzj	40	11	basis	basis	NN
cord-277417-f71jwdzj	40	12	of	of	IN
cord-277417-f71jwdzj	40	13	in	in	FW
cord-277417-f71jwdzj	40	14	vitro	vitro	FW
cord-277417-f71jwdzj	40	15	studies	study	NNS
cord-277417-f71jwdzj	40	16	and	and	CC
cord-277417-f71jwdzj	40	17	mouse	mouse	NN
cord-277417-f71jwdzj	40	18	models	model	NNS
cord-277417-f71jwdzj	40	19	have	have	VBP
cord-277417-f71jwdzj	40	20	often	often	RB
cord-277417-f71jwdzj	40	21	not	not	RB
cord-277417-f71jwdzj	40	22	been	be	VBN
cord-277417-f71jwdzj	40	23	upheld	uphold	VBN
cord-277417-f71jwdzj	40	24	in	in	IN
cord-277417-f71jwdzj	40	25	reverse	reverse	JJ
cord-277417-f71jwdzj	40	26	genetic	genetic	JJ
cord-277417-f71jwdzj	40	27	experiments	experiment	NNS
cord-277417-f71jwdzj	40	28	using	use	VBG
cord-277417-f71jwdzj	40	29	the	the	DT
cord-277417-f71jwdzj	40	30	natural	natural	JJ
cord-277417-f71jwdzj	40	31	rabbit	rabbit	NN
cord-277417-f71jwdzj	40	32	host	host	NN
cord-277417-f71jwdzj	40	33	17	17	CD
cord-277417-f71jwdzj	40	34	.	.	.
cord-277417-f71jwdzj	41	1	Similarly	similarly	RB
cord-277417-f71jwdzj	41	2	,	,	,
cord-277417-f71jwdzj	41	3	despite	despite	IN
cord-277417-f71jwdzj	41	4	the	the	DT
cord-277417-f71jwdzj	41	5	regularity	regularity	NN
cord-277417-f71jwdzj	41	6	of	of	IN
cord-277417-f71jwdzj	41	7	their	-PRON-	PRP$
cord-277417-f71jwdzj	41	8	use	use	NN
cord-277417-f71jwdzj	41	9	,	,	,
cord-277417-f71jwdzj	41	10	there	there	EX
cord-277417-f71jwdzj	41	11	has	have	VBZ
cord-277417-f71jwdzj	41	12	been	be	VBN
cord-277417-f71jwdzj	41	13	a	a	DT
cord-277417-f71jwdzj	41	14	long	long	RB
cord-277417-f71jwdzj	41	15	-	-	HYPH
cord-277417-f71jwdzj	41	16	standing	stand	VBG
cord-277417-f71jwdzj	41	17	debate	debate	NN
cord-277417-f71jwdzj	41	18	over	over	IN
cord-277417-f71jwdzj	41	19	the	the	DT
cord-277417-f71jwdzj	41	20	validity	validity	NN
cord-277417-f71jwdzj	41	21	of	of	IN
cord-277417-f71jwdzj	41	22	ferrets	ferret	NNS
cord-277417-f71jwdzj	41	23	as	as	IN
cord-277417-f71jwdzj	41	24	accurate	accurate	JJ
cord-277417-f71jwdzj	41	25	models	model	NNS
cord-277417-f71jwdzj	41	26	for	for	IN
cord-277417-f71jwdzj	41	27	human	human	JJ
cord-277417-f71jwdzj	41	28	influenza	influenza	NN
cord-277417-f71jwdzj	41	29	18	18	CD
cord-277417-f71jwdzj	41	30	.	.	.
cord-277417-f71jwdzj	42	1	Bridging	bridge	VBG
cord-277417-f71jwdzj	42	2	the	the	DT
cord-277417-f71jwdzj	42	3	gap	gap	NN
cord-277417-f71jwdzj	42	4	between	between	IN
cord-277417-f71jwdzj	42	5	the	the	DT
cord-277417-f71jwdzj	42	6	theoretical	theoretical	JJ
cord-277417-f71jwdzj	42	7	and	and	CC
cord-277417-f71jwdzj	42	8	empirical	empirical	JJ
cord-277417-f71jwdzj	42	9	approaches	approach	NNS
cord-277417-f71jwdzj	42	10	would	would	MD
cord-277417-f71jwdzj	42	11	bring	bring	VB
cord-277417-f71jwdzj	42	12	a	a	DT
cord-277417-f71jwdzj	42	13	new	new	JJ
cord-277417-f71jwdzj	42	14	impetus	impetus	NN
cord-277417-f71jwdzj	42	15	to	to	IN
cord-277417-f71jwdzj	42	16	studies	study	NNS
cord-277417-f71jwdzj	42	17	of	of	IN
cord-277417-f71jwdzj	42	18	virulence	virulence	NN
cord-277417-f71jwdzj	42	19	evolution	evolution	NN
cord-277417-f71jwdzj	42	20	.	.	.
cord-277417-f71jwdzj	43	1	In	in	IN
cord-277417-f71jwdzj	43	2	this	this	DT
cord-277417-f71jwdzj	43	3	Review	Review	NNP
cord-277417-f71jwdzj	43	4	,	,	,
cord-277417-f71jwdzj	43	5	we	-PRON-	PRP
cord-277417-f71jwdzj	43	6	outline	outline	VBP
cord-277417-f71jwdzj	43	7	how	how	WRB
cord-277417-f71jwdzj	43	8	this	this	DT
cord-277417-f71jwdzj	43	9	can	can	MD
cord-277417-f71jwdzj	43	10	be	be	VB
cord-277417-f71jwdzj	43	11	achieved	achieve	VBN
cord-277417-f71jwdzj	43	12	within	within	IN
cord-277417-f71jwdzj	43	13	a	a	DT
cord-277417-f71jwdzj	43	14	phylogenomics	phylogenomic	NNS
cord-277417-f71jwdzj	43	15	framework	framework	NN
cord-277417-f71jwdzj	43	16	.	.	.
cord-277417-f71jwdzj	44	1	We	-PRON-	PRP
cord-277417-f71jwdzj	44	2	show	show	VBP
cord-277417-f71jwdzj	44	3	that	that	IN
cord-277417-f71jwdzj	44	4	virus	virus	NN
cord-277417-f71jwdzj	44	5	phylogenies	phylogeny	NNS
cord-277417-f71jwdzj	44	6	are	be	VBP
cord-277417-f71jwdzj	44	7	being	be	VBG
cord-277417-f71jwdzj	44	8	increasingly	increasingly	RB
cord-277417-f71jwdzj	44	9	used	use	VBN
cord-277417-f71jwdzj	44	10	to	to	TO
cord-277417-f71jwdzj	44	11	help	help	VB
cord-277417-f71jwdzj	44	12	identify	identify	VB
cord-277417-f71jwdzj	44	13	virulence	virulence	NN
cord-277417-f71jwdzj	44	14	determinants	determinant	NNS
cord-277417-f71jwdzj	44	15	and	and	CC
cord-277417-f71jwdzj	44	16	that	that	IN
cord-277417-f71jwdzj	44	17	the	the	DT
cord-277417-f71jwdzj	44	18	data	datum	NNS
cord-277417-f71jwdzj	44	19	obtained	obtain	VBN
cord-277417-f71jwdzj	44	20	can	can	MD
cord-277417-f71jwdzj	44	21	be	be	VB
cord-277417-f71jwdzj	44	22	used	use	VBN
cord-277417-f71jwdzj	44	23	to	to	TO
cord-277417-f71jwdzj	44	24	test	test	VB
cord-277417-f71jwdzj	44	25	general	general	JJ
cord-277417-f71jwdzj	44	26	theories	theory	NNS
cord-277417-f71jwdzj	44	27	of	of	IN
cord-277417-f71jwdzj	44	28	virulence	virulence	NN
cord-277417-f71jwdzj	44	29	evolution	evolution	NN
cord-277417-f71jwdzj	44	30	.	.	.
cord-277417-f71jwdzj	45	1	Such	such	JJ
cord-277417-f71jwdzj	45	2	a	a	DT
cord-277417-f71jwdzj	45	3	phylogenomic	phylogenomic	JJ
cord-277417-f71jwdzj	45	4	approach	approach	NN
cord-277417-f71jwdzj	45	5	to	to	IN
cord-277417-f71jwdzj	45	6	studying	study	VBG
cord-277417-f71jwdzj	45	7	virulence	virulence	NN
cord-277417-f71jwdzj	45	8	evolution	evolution	NN
cord-277417-f71jwdzj	45	9	is	be	VBZ
cord-277417-f71jwdzj	45	10	timely	timely	JJ
cord-277417-f71jwdzj	45	11	because	because	IN
cord-277417-f71jwdzj	45	12	of	of	IN
cord-277417-f71jwdzj	45	13	the	the	DT
cord-277417-f71jwdzj	45	14	rapidity	rapidity	NN
cord-277417-f71jwdzj	45	15	with	with	IN
cord-277417-f71jwdzj	45	16	which	which	WDT
cord-277417-f71jwdzj	45	17	virus	virus	NN
cord-277417-f71jwdzj	45	18	genome	genome	NN
cord-277417-f71jwdzj	45	19	sequence	sequence	NN
cord-277417-f71jwdzj	45	20	data	datum	NNS
cord-277417-f71jwdzj	45	21	are	be	VBP
cord-277417-f71jwdzj	45	22	now	now	RB
cord-277417-f71jwdzj	45	23	being	be	VBG
cord-277417-f71jwdzj	45	24	generated	generate	VBN
cord-277417-f71jwdzj	45	25	,	,	,
cord-277417-f71jwdzj	45	26	including	include	VBG
cord-277417-f71jwdzj	45	27	during	during	IN
cord-277417-f71jwdzj	45	28	ongoing	ongoing	JJ
cord-277417-f71jwdzj	45	29	disease	disease	NN
cord-277417-f71jwdzj	45	30	outbreaks	outbreak	NNS
cord-277417-f71jwdzj	45	31	of	of	IN
cord-277417-f71jwdzj	45	32	emerging	emerge	VBG
cord-277417-f71jwdzj	45	33	viruses	virus	NNS
cord-277417-f71jwdzj	45	34	[	[	-LRB-
cord-277417-f71jwdzj	45	35	19	19	CD
cord-277417-f71jwdzj	45	36	]	]	-RRB-
cord-277417-f71jwdzj	46	1	[	[	-LRB-
cord-277417-f71jwdzj	46	2	20	20	CD
cord-277417-f71jwdzj	46	3	]	]	-RRB-
cord-277417-f71jwdzj	46	4	[	[	-LRB-
cord-277417-f71jwdzj	46	5	21	21	CD
cord-277417-f71jwdzj	46	6	]	]	-RRB-
cord-277417-f71jwdzj	46	7	,	,	,
cord-277417-f71jwdzj	46	8	and	and	CC
cord-277417-f71jwdzj	46	9	because	because	IN
cord-277417-f71jwdzj	46	10	of	of	IN
cord-277417-f71jwdzj	46	11	the	the	DT
cord-277417-f71jwdzj	46	12	development	development	NN
cord-277417-f71jwdzj	46	13	of	of	IN
cord-277417-f71jwdzj	46	14	new	new	JJ
cord-277417-f71jwdzj	46	15	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	46	16	-	-	HYPH
cord-277417-f71jwdzj	46	17	based	base	VBN
cord-277417-f71jwdzj	46	18	methods	method	NNS
cord-277417-f71jwdzj	46	19	for	for	IN
cord-277417-f71jwdzj	46	20	studying	study	VBG
cord-277417-f71jwdzj	46	21	and	and	CC
cord-277417-f71jwdzj	46	22	visualizing	visualize	VBG
cord-277417-f71jwdzj	46	23	genomic	genomic	JJ
cord-277417-f71jwdzj	46	24	data	datum	NNS
cord-277417-f71jwdzj	46	25	[	[	-LRB-
cord-277417-f71jwdzj	46	26	22	22	CD
cord-277417-f71jwdzj	46	27	]	]	-RRB-
cord-277417-f71jwdzj	47	1	[	[	-LRB-
cord-277417-f71jwdzj	47	2	23	23	CD
cord-277417-f71jwdzj	47	3	]	]	-RRB-
cord-277417-f71jwdzj	47	4	[	[	-LRB-
cord-277417-f71jwdzj	47	5	24	24	CD
cord-277417-f71jwdzj	47	6	]	]	-RRB-
cord-277417-f71jwdzj	47	7	.	.	.
cord-277417-f71jwdzj	48	1	However	however	RB
cord-277417-f71jwdzj	48	2	,	,	,
cord-277417-f71jwdzj	48	3	the	the	DT
cord-277417-f71jwdzj	48	4	success	success	NN
cord-277417-f71jwdzj	48	5	of	of	IN
cord-277417-f71jwdzj	48	6	this	this	DT
cord-277417-f71jwdzj	48	7	approach	approach	NN
cord-277417-f71jwdzj	48	8	also	also	RB
cord-277417-f71jwdzj	48	9	requires	require	VBZ
cord-277417-f71jwdzj	48	10	that	that	IN
cord-277417-f71jwdzj	48	11	phylogenomic	phylogenomic	NNP
cord-277417-f71jwdzj	48	12	data	datum	NNS
cord-277417-f71jwdzj	48	13	are	be	VBP
cord-277417-f71jwdzj	48	14	combined	combine	VBN
cord-277417-f71jwdzj	48	15	with	with	IN
cord-277417-f71jwdzj	48	16	relevant	relevant	JJ
cord-277417-f71jwdzj	48	17	clinical	clinical	JJ
cord-277417-f71jwdzj	48	18	,	,	,
cord-277417-f71jwdzj	48	19	epidemiological	epidemiological	JJ
cord-277417-f71jwdzj	48	20	and	and	CC
cord-277417-f71jwdzj	48	21	experimental	experimental	JJ
cord-277417-f71jwdzj	48	22	metadata	metadata	NN
cord-277417-f71jwdzj	48	23	so	so	IN
cord-277417-f71jwdzj	48	24	that	that	IN
cord-277417-f71jwdzj	48	25	a	a	DT
cord-277417-f71jwdzj	48	26	direct	direct	JJ
cord-277417-f71jwdzj	48	27	link	link	NN
cord-277417-f71jwdzj	48	28	can	can	MD
cord-277417-f71jwdzj	48	29	be	be	VB
cord-277417-f71jwdzj	48	30	made	make	VBN
cord-277417-f71jwdzj	48	31	between	between	IN
cord-277417-f71jwdzj	48	32	virulence	virulence	NN
cord-277417-f71jwdzj	48	33	,	,	,
cord-277417-f71jwdzj	48	34	virus	virus	NN
cord-277417-f71jwdzj	48	35	genotype	genotype	NN
cord-277417-f71jwdzj	48	36	and	and	CC
cord-277417-f71jwdzj	48	37	phenotype	phenotype	NN
cord-277417-f71jwdzj	48	38	,	,	,
cord-277417-f71jwdzj	48	39	and	and	CC
cord-277417-f71jwdzj	48	40	population	population	NN
cord-277417-f71jwdzj	48	41	fitness	fitness	NN
cord-277417-f71jwdzj	48	42	.	.	.
cord-277417-f71jwdzj	49	1	Arguably	arguably	RB
cord-277417-f71jwdzj	49	2	the	the	DT
cord-277417-f71jwdzj	49	3	most	most	RBS
cord-277417-f71jwdzj	49	4	interesting	interesting	JJ
cord-277417-f71jwdzj	49	5	context	context	NN
cord-277417-f71jwdzj	49	6	of	of	IN
cord-277417-f71jwdzj	49	7	virulence	virulence	NN
cord-277417-f71jwdzj	49	8	evolution	evolution	NN
cord-277417-f71jwdzj	49	9	is	be	VBZ
cord-277417-f71jwdzj	49	10	following	follow	VBG
cord-277417-f71jwdzj	49	11	a	a	DT
cord-277417-f71jwdzj	49	12	host	host	NN
cord-277417-f71jwdzj	49	13	jump	jump	NN
cord-277417-f71jwdzj	49	14	as	as	IN
cord-277417-f71jwdzj	49	15	this	this	DT
cord-277417-f71jwdzj	49	16	sits	sit	VBZ
cord-277417-f71jwdzj	49	17	at	at	IN
cord-277417-f71jwdzj	49	18	the	the	DT
cord-277417-f71jwdzj	49	19	heart	heart	NN
cord-277417-f71jwdzj	49	20	of	of	IN
cord-277417-f71jwdzj	49	21	virus	virus	NN
cord-277417-f71jwdzj	49	22	emergence	emergence	NN
cord-277417-f71jwdzj	49	23	,	,	,
cord-277417-f71jwdzj	49	24	and	and	CC
cord-277417-f71jwdzj	49	25	the	the	DT
cord-277417-f71jwdzj	49	26	question	question	NN
cord-277417-f71jwdzj	49	27	of	of	IN
cord-277417-f71jwdzj	49	28	how	how	WRB
cord-277417-f71jwdzj	49	29	virulence	virulence	NN
cord-277417-f71jwdzj	49	30	will	will	MD
cord-277417-f71jwdzj	49	31	evolve	evolve	VB
cord-277417-f71jwdzj	49	32	is	be	VBZ
cord-277417-f71jwdzj	49	33	commonly	commonly	RB
cord-277417-f71jwdzj	49	34	asked	ask	VBN
cord-277417-f71jwdzj	49	35	following	follow	VBG
cord-277417-f71jwdzj	49	36	the	the	DT
cord-277417-f71jwdzj	49	37	appearance	appearance	NN
cord-277417-f71jwdzj	49	38	of	of	IN
cord-277417-f71jwdzj	49	39	a	a	DT
cord-277417-f71jwdzj	49	40	new	new	JJ
cord-277417-f71jwdzj	49	41	virus	virus	NN
cord-277417-f71jwdzj	49	42	or	or	CC
cord-277417-f71jwdzj	49	43	the	the	DT
cord-277417-f71jwdzj	49	44	emergence	emergence	NN
cord-277417-f71jwdzj	49	45	of	of	IN
cord-277417-f71jwdzj	49	46	an	an	DT
cord-277417-f71jwdzj	49	47	existing	exist	VBG
cord-277417-f71jwdzj	49	48	virus	virus	NN
cord-277417-f71jwdzj	49	49	with	with	IN
cord-277417-f71jwdzj	49	50	altered	alter	VBN
cord-277417-f71jwdzj	49	51	host	host	NN
cord-277417-f71jwdzj	49	52	range	range	NN
cord-277417-f71jwdzj	49	53	(	(	-LRB-
cord-277417-f71jwdzj	49	54	box	box	NN
cord-277417-f71jwdzj	49	55	1	1	CD
cord-277417-f71jwdzj	49	56	)	)	-RRB-
cord-277417-f71jwdzj	49	57	.	.	.
cord-277417-f71jwdzj	50	1	To	to	TO
cord-277417-f71jwdzj	50	2	make	make	VB
cord-277417-f71jwdzj	50	3	meaningful	meaningful	JJ
cord-277417-f71jwdzj	50	4	inferences	inference	NNS
cord-277417-f71jwdzj	50	5	,	,	,
cord-277417-f71jwdzj	50	6	it	-PRON-	PRP
cord-277417-f71jwdzj	50	7	is	be	VBZ
cord-277417-f71jwdzj	50	8	important	important	JJ
cord-277417-f71jwdzj	50	9	to	to	TO
cord-277417-f71jwdzj	50	10	compare	compare	VB
cord-277417-f71jwdzj	50	11	virulence	virulence	NN
cord-277417-f71jwdzj	50	12	in	in	IN
cord-277417-f71jwdzj	50	13	both	both	CC
cord-277417-f71jwdzj	50	14	the	the	DT
cord-277417-f71jwdzj	50	15	reservoir	reservoir	NN
cord-277417-f71jwdzj	50	16	(	(	-LRB-
cord-277417-f71jwdzj	50	17	that	that	RB
cord-277417-f71jwdzj	50	18	is	is	RB
cord-277417-f71jwdzj	50	19	,	,	,
cord-277417-f71jwdzj	50	20	donor	donor	NN
cord-277417-f71jwdzj	50	21	)	)	-RRB-
cord-277417-f71jwdzj	50	22	and	and	CC
cord-277417-f71jwdzj	50	23	novel	novel	NN
cord-277417-f71jwdzj	50	24	(	(	-LRB-
cord-277417-f71jwdzj	50	25	that	that	RB
cord-277417-f71jwdzj	50	26	is	is	RB
cord-277417-f71jwdzj	50	27	,	,	,
cord-277417-f71jwdzj	50	28	recipient	recipient	NN
cord-277417-f71jwdzj	50	29	)	)	-RRB-
cord-277417-f71jwdzj	50	30	host	host	NN
cord-277417-f71jwdzj	50	31	species	specie	NNS
cord-277417-f71jwdzj	50	32	.	.	.
cord-277417-f71jwdzj	51	1	Although	although	IN
cord-277417-f71jwdzj	51	2	this	this	DT
cord-277417-f71jwdzj	51	3	may	may	MD
cord-277417-f71jwdzj	51	4	sound	sound	VB
cord-277417-f71jwdzj	51	5	straightforward	straightforward	JJ
cord-277417-f71jwdzj	51	6	and	and	CC
cord-277417-f71jwdzj	51	7	is	be	VBZ
cord-277417-f71jwdzj	51	8	tractable	tractable	JJ
cord-277417-f71jwdzj	51	9	in	in	IN
cord-277417-f71jwdzj	51	10	some	some	DT
cord-277417-f71jwdzj	51	11	cases	case	NNS
cord-277417-f71jwdzj	51	12	25	25	CD
cord-277417-f71jwdzj	51	13	,	,	,
cord-277417-f71jwdzj	51	14	in	in	IN
cord-277417-f71jwdzj	51	15	reality	reality	NN
cord-277417-f71jwdzj	51	16	it	-PRON-	PRP
cord-277417-f71jwdzj	51	17	faces	face	VBZ
cord-277417-f71jwdzj	51	18	a	a	DT
cord-277417-f71jwdzj	51	19	number	number	NN
cord-277417-f71jwdzj	51	20	of	of	IN
cord-277417-f71jwdzj	51	21	difficulties	difficulty	NNS
cord-277417-f71jwdzj	51	22	.	.	.
cord-277417-f71jwdzj	52	1	In	in	IN
cord-277417-f71jwdzj	52	2	many	many	JJ
cord-277417-f71jwdzj	52	3	cases	case	NNS
cord-277417-f71jwdzj	52	4	,	,	,
cord-277417-f71jwdzj	52	5	including	include	VBG
cord-277417-f71jwdzj	52	6	common	common	JJ
cord-277417-f71jwdzj	52	7	infections	infection	NNS
cord-277417-f71jwdzj	52	8	such	such	JJ
cord-277417-f71jwdzj	52	9	as	as	IN
cord-277417-f71jwdzj	52	10	hepatitis	hepatitis	NN
cord-277417-f71jwdzj	52	11	C	C	NNP
cord-277417-f71jwdzj	52	12	virus	virus	NN
cord-277417-f71jwdzj	52	13	26	26	CD
cord-277417-f71jwdzj	52	14	,	,	,
cord-277417-f71jwdzj	52	15	as	as	RB
cord-277417-f71jwdzj	52	16	well	well	RB
cord-277417-f71jwdzj	52	17	as	as	IN
cord-277417-f71jwdzj	52	18	emerging	emerge	VBG
cord-277417-f71jwdzj	52	19	infectious	infectious	JJ
cord-277417-f71jwdzj	52	20	diseases	disease	NNS
cord-277417-f71jwdzj	52	21	such	such	JJ
cord-277417-f71jwdzj	52	22	as	as	IN
cord-277417-f71jwdzj	52	23	Zika	Zika	NNP
cord-277417-f71jwdzj	52	24	virus	virus	NN
cord-277417-f71jwdzj	52	25	(	(	-LRB-
cord-277417-f71jwdzj	52	26	ZIKV	ZIKV	NNP
cord-277417-f71jwdzj	52	27	)	)	-RRB-
cord-277417-f71jwdzj	52	28	,	,	,
cord-277417-f71jwdzj	52	29	the	the	DT
cord-277417-f71jwdzj	52	30	reservoir	reservoir	NN
cord-277417-f71jwdzj	52	31	species	species	NN
cord-277417-f71jwdzj	52	32	is	be	VBZ
cord-277417-f71jwdzj	52	33	unknown	unknown	JJ
cord-277417-f71jwdzj	52	34	or	or	CC
cord-277417-f71jwdzj	52	35	is	be	VBZ
cord-277417-f71jwdzj	52	36	at	at	IN
cord-277417-f71jwdzj	52	37	best	good	JJS
cord-277417-f71jwdzj	52	38	uncertain	uncertain	JJ
cord-277417-f71jwdzj	52	39	.	.	.
cord-277417-f71jwdzj	53	1	Even	even	RB
cord-277417-f71jwdzj	53	2	if	if	IN
cord-277417-f71jwdzj	53	3	a	a	DT
cord-277417-f71jwdzj	53	4	reservoir	reservoir	NN
cord-277417-f71jwdzj	53	5	species	species	NN
cord-277417-f71jwdzj	53	6	is	be	VBZ
cord-277417-f71jwdzj	53	7	known	know	VBN
cord-277417-f71jwdzj	53	8	,	,	,
cord-277417-f71jwdzj	53	9	we	-PRON-	PRP
cord-277417-f71jwdzj	53	10	generally	generally	RB
cord-277417-f71jwdzj	53	11	know	know	VBP
cord-277417-f71jwdzj	53	12	little	little	JJ
cord-277417-f71jwdzj	53	13	,	,	,
cord-277417-f71jwdzj	53	14	if	if	IN
cord-277417-f71jwdzj	53	15	anything	anything	NN
cord-277417-f71jwdzj	53	16	,	,	,
cord-277417-f71jwdzj	53	17	about	about	IN
cord-277417-f71jwdzj	53	18	virulence	virulence	NN
cord-277417-f71jwdzj	53	19	in	in	IN
cord-277417-f71jwdzj	53	20	that	that	DT
cord-277417-f71jwdzj	53	21	species	species	NN
cord-277417-f71jwdzj	53	22	,	,	,
cord-277417-f71jwdzj	53	23	and	and	CC
cord-277417-f71jwdzj	53	24	there	there	EX
cord-277417-f71jwdzj	53	25	is	be	VBZ
cord-277417-f71jwdzj	53	26	likely	likely	JJ
cord-277417-f71jwdzj	53	27	to	to	TO
cord-277417-f71jwdzj	53	28	be	be	VB
cord-277417-f71jwdzj	53	29	an	an	DT
cord-277417-f71jwdzj	53	30	ascertainment	ascertainment	NN
cord-277417-f71jwdzj	53	31	bias	bias	NN
cord-277417-f71jwdzj	53	32	towards	towards	IN
cord-277417-f71jwdzj	53	33	the	the	DT
cord-277417-f71jwdzj	53	34	most	most	RBS
cord-277417-f71jwdzj	53	35	virulent	virulent	JJ
cord-277417-f71jwdzj	53	36	cases	case	NNS
cord-277417-f71jwdzj	53	37	.	.	.
cord-277417-f71jwdzj	54	1	For	for	IN
cord-277417-f71jwdzj	54	2	example	example	NN
cord-277417-f71jwdzj	54	3	,	,	,
cord-277417-f71jwdzj	54	4	although	although	IN
cord-277417-f71jwdzj	54	5	species	specie	NNS
cord-277417-f71jwdzj	54	6	of	of	IN
cord-277417-f71jwdzj	54	7	fruit	fruit	NN
cord-277417-f71jwdzj	54	8	bats	bat	NNS
cord-277417-f71jwdzj	54	9	appear	appear	VBP
cord-277417-f71jwdzj	54	10	to	to	TO
cord-277417-f71jwdzj	54	11	be	be	VB
cord-277417-f71jwdzj	54	12	reservoirs	reservoir	NNS
cord-277417-f71jwdzj	54	13	for	for	IN
cord-277417-f71jwdzj	54	14	Ebola	Ebola	NNP
cord-277417-f71jwdzj	54	15	virus	virus	NN
cord-277417-f71jwdzj	54	16	(	(	-LRB-
cord-277417-f71jwdzj	54	17	EBOV	EBOV	NNP
cord-277417-f71jwdzj	54	18	)	)	-RRB-
cord-277417-f71jwdzj	55	1	27	27	CD
cord-277417-f71jwdzj	55	2	,	,	,
cord-277417-f71jwdzj	55	3	little	little	JJ
cord-277417-f71jwdzj	55	4	is	be	VBZ
cord-277417-f71jwdzj	55	5	known	know	VBN
cord-277417-f71jwdzj	55	6	about	about	IN
cord-277417-f71jwdzj	55	7	its	-PRON-	PRP$
cord-277417-f71jwdzj	55	8	virulence	virulence	NN
cord-277417-f71jwdzj	55	9	in	in	IN
cord-277417-f71jwdzj	55	10	these	these	DT
cord-277417-f71jwdzj	55	11	animals	animal	NNS
cord-277417-f71jwdzj	55	12	28	28	CD
cord-277417-f71jwdzj	55	13	,	,	,
cord-277417-f71jwdzj	55	14	as	as	IN
cord-277417-f71jwdzj	55	15	is	be	VBZ
cord-277417-f71jwdzj	55	16	true	true	JJ
cord-277417-f71jwdzj	55	17	of	of	IN
cord-277417-f71jwdzj	55	18	many	many	JJ
cord-277417-f71jwdzj	55	19	wildlife	wildlife	NN
cord-277417-f71jwdzj	55	20	infections	infection	NNS
cord-277417-f71jwdzj	55	21	.	.	.
cord-277417-f71jwdzj	56	1	The	the	DT
cord-277417-f71jwdzj	56	2	identification	identification	NN
cord-277417-f71jwdzj	56	3	of	of	IN
cord-277417-f71jwdzj	56	4	host	host	NN
cord-277417-f71jwdzj	56	5	species	specie	NNS
cord-277417-f71jwdzj	56	6	may	may	MD
cord-277417-f71jwdzj	56	7	also	also	RB
cord-277417-f71jwdzj	56	8	change	change	VB
cord-277417-f71jwdzj	56	9	with	with	IN
cord-277417-f71jwdzj	56	10	better	well	JJR
cord-277417-f71jwdzj	56	11	sampling	sampling	NN
cord-277417-f71jwdzj	56	12	,	,	,
cord-277417-f71jwdzj	56	13	which	which	WDT
cord-277417-f71jwdzj	56	14	is	be	VBZ
cord-277417-f71jwdzj	56	15	invariably	invariably	RB
cord-277417-f71jwdzj	56	16	poor	poor	JJ
cord-277417-f71jwdzj	56	17	in	in	IN
cord-277417-f71jwdzj	56	18	wildlife	wildlife	NN
cord-277417-f71jwdzj	56	19	.	.	.
cord-277417-f71jwdzj	57	1	For	for	IN
cord-277417-f71jwdzj	57	2	example	example	NN
cord-277417-f71jwdzj	57	3	,	,	,
cord-277417-f71jwdzj	57	4	it	-PRON-	PRP
cord-277417-f71jwdzj	57	5	was	be	VBD
cord-277417-f71jwdzj	57	6	long	long	RB
cord-277417-f71jwdzj	57	7	thought	think	VBN
cord-277417-f71jwdzj	57	8	that	that	IN
cord-277417-f71jwdzj	57	9	the	the	DT
cord-277417-f71jwdzj	57	10	canine	canine	JJ
cord-277417-f71jwdzj	57	11	parvovirus	parvovirus	NN
cord-277417-f71jwdzj	57	12	(	(	-LRB-
cord-277417-f71jwdzj	57	13	CPV	CPV	NNP
cord-277417-f71jwdzj	57	14	)	)	-RRB-
cord-277417-f71jwdzj	57	15	that	that	WDT
cord-277417-f71jwdzj	57	16	emerged	emerge	VBD
cord-277417-f71jwdzj	57	17	in	in	IN
cord-277417-f71jwdzj	57	18	dogs	dog	NNS
cord-277417-f71jwdzj	57	19	in	in	IN
cord-277417-f71jwdzj	57	20	the	the	DT
cord-277417-f71jwdzj	57	21	late	late	JJ
cord-277417-f71jwdzj	57	22	1970s	1970	NNS
cord-277417-f71jwdzj	57	23	had	have	VBD
cord-277417-f71jwdzj	57	24	jumped	jump	VBN
cord-277417-f71jwdzj	57	25	from	from	IN
cord-277417-f71jwdzj	57	26	cats	cat	NNS
cord-277417-f71jwdzj	57	27	infected	infect	VBN
cord-277417-f71jwdzj	57	28	by	by	IN
cord-277417-f71jwdzj	57	29	a	a	DT
cord-277417-f71jwdzj	57	30	closely	closely	RB
cord-277417-f71jwdzj	57	31	related	related	JJ
cord-277417-f71jwdzj	57	32	virus	virus	NN
cord-277417-f71jwdzj	57	33	29	29	CD
cord-277417-f71jwdzj	57	34	.	.	.
cord-277417-f71jwdzj	58	1	However	however	RB
cord-277417-f71jwdzj	58	2	,	,	,
cord-277417-f71jwdzj	58	3	more	more	RBR
cord-277417-f71jwdzj	58	4	recent	recent	JJ
cord-277417-f71jwdzj	58	5	sampling	sampling	NN
cord-277417-f71jwdzj	58	6	of	of	IN
cord-277417-f71jwdzj	58	7	wild	wild	JJ
cord-277417-f71jwdzj	58	8	carnivore	carnivore	NN
cord-277417-f71jwdzj	58	9	species	specie	NNS
cord-277417-f71jwdzj	58	10	has	have	VBZ
cord-277417-f71jwdzj	58	11	shown	show	VBN
cord-277417-f71jwdzj	58	12	this	this	DT
cord-277417-f71jwdzj	58	13	to	to	TO
cord-277417-f71jwdzj	58	14	be	be	VB
cord-277417-f71jwdzj	58	15	incorrect	incorrect	JJ
cord-277417-f71jwdzj	58	16	,	,	,
cord-277417-f71jwdzj	58	17	such	such	JJ
cord-277417-f71jwdzj	58	18	that	that	IN
cord-277417-f71jwdzj	58	19	the	the	DT
cord-277417-f71jwdzj	58	20	true	true	JJ
cord-277417-f71jwdzj	58	21	reservoir	reservoir	NN
cord-277417-f71jwdzj	58	22	species	specie	NNS
cord-277417-f71jwdzj	58	23	for	for	IN
cord-277417-f71jwdzj	58	24	CPV	CPV	NNP
cord-277417-f71jwdzj	58	25	is	be	VBZ
cord-277417-f71jwdzj	58	26	unclear	unclear	JJ
cord-277417-f71jwdzj	58	27	30	30	CD
cord-277417-f71jwdzj	58	28	.	.	.
cord-277417-f71jwdzj	59	1	Therefore	therefore	RB
cord-277417-f71jwdzj	59	2	,	,	,
cord-277417-f71jwdzj	59	3	it	-PRON-	PRP
cord-277417-f71jwdzj	59	4	is	be	VBZ
cord-277417-f71jwdzj	59	5	crucial	crucial	JJ
cord-277417-f71jwdzj	59	6	to	to	TO
cord-277417-f71jwdzj	59	7	understand	understand	VB
cord-277417-f71jwdzj	59	8	disease	disease	NN
cord-277417-f71jwdzj	59	9	processes	process	NNS
cord-277417-f71jwdzj	59	10	,	,	,
cord-277417-f71jwdzj	59	11	including	include	VBG
cord-277417-f71jwdzj	59	12	virulence	virulence	NN
cord-277417-f71jwdzj	59	13	,	,	,
cord-277417-f71jwdzj	59	14	in	in	IN
cord-277417-f71jwdzj	59	15	reservoir	reservoir	NN
cord-277417-f71jwdzj	59	16	hosts	host	NNS
cord-277417-f71jwdzj	59	17	under	under	IN
cord-277417-f71jwdzj	59	18	natural	natural	JJ
cord-277417-f71jwdzj	59	19	conditions	condition	NNS
cord-277417-f71jwdzj	59	20	,	,	,
cord-277417-f71jwdzj	59	21	which	which	WDT
cord-277417-f71jwdzj	59	22	will	will	MD
cord-277417-f71jwdzj	59	23	require	require	VB
cord-277417-f71jwdzj	59	24	more	more	RBR
cord-277417-f71jwdzj	59	25	detailed	detailed	JJ
cord-277417-f71jwdzj	59	26	studies	study	NNS
cord-277417-f71jwdzj	59	27	of	of	IN
cord-277417-f71jwdzj	59	28	animal	animal	NN
cord-277417-f71jwdzj	59	29	ecology	ecology	NN
cord-277417-f71jwdzj	59	30	.	.	.
cord-277417-f71jwdzj	60	1	Although	although	IN
cord-277417-f71jwdzj	60	2	we	-PRON-	PRP
cord-277417-f71jwdzj	60	3	currently	currently	RB
cord-277417-f71jwdzj	60	4	know	know	VBP
cord-277417-f71jwdzj	60	5	little	little	JJ
cord-277417-f71jwdzj	60	6	about	about	IN
cord-277417-f71jwdzj	60	7	virulence	virulence	NN
cord-277417-f71jwdzj	60	8	in	in	IN
cord-277417-f71jwdzj	60	9	reservoir	reservoir	NN
cord-277417-f71jwdzj	60	10	species	specie	NNS
cord-277417-f71jwdzj	60	11	,	,	,
cord-277417-f71jwdzj	60	12	comparative	comparative	JJ
cord-277417-f71jwdzj	60	13	data	datum	NNS
cord-277417-f71jwdzj	60	14	tell	tell	VBP
cord-277417-f71jwdzj	60	15	us	-PRON-	PRP
cord-277417-f71jwdzj	60	16	that	that	IN
cord-277417-f71jwdzj	60	17	,	,	,
cord-277417-f71jwdzj	60	18	on	on	IN
cord-277417-f71jwdzj	60	19	average	average	JJ
cord-277417-f71jwdzj	60	20	,	,	,
cord-277417-f71jwdzj	60	21	low	low	JJ
cord-277417-f71jwdzj	60	22	-	-	HYPH
cord-277417-f71jwdzj	60	23	virulence	virulence	NN
cord-277417-f71jwdzj	60	24	infections	infection	NNS
cord-277417-f71jwdzj	60	25	have	have	VBP
cord-277417-f71jwdzj	60	26	a	a	DT
cord-277417-f71jwdzj	60	27	greater	great	JJR
cord-277417-f71jwdzj	60	28	chance	chance	NN
cord-277417-f71jwdzj	60	29	of	of	IN
cord-277417-f71jwdzj	60	30	successfully	successfully	RB
cord-277417-f71jwdzj	60	31	establishing	establish	VBG
cord-277417-f71jwdzj	60	32	transmission	transmission	NN
cord-277417-f71jwdzj	60	33	cycles	cycle	NNS
cord-277417-f71jwdzj	60	34	in	in	IN
cord-277417-f71jwdzj	60	35	humans	human	NNS
cord-277417-f71jwdzj	60	36	than	than	IN
cord-277417-f71jwdzj	60	37	viruses	virus	NNS
cord-277417-f71jwdzj	60	38	with	with	IN
cord-277417-f71jwdzj	60	39	higher	high	JJR
cord-277417-f71jwdzj	60	40	mortality	mortality	NN
cord-277417-f71jwdzj	60	41	31	31	CD
cord-277417-f71jwdzj	60	42	.	.	.
cord-277417-f71jwdzj	61	1	This	this	DT
cord-277417-f71jwdzj	61	2	greater	great	JJR
cord-277417-f71jwdzj	61	3	chance	chance	NN
cord-277417-f71jwdzj	61	4	is	be	VBZ
cord-277417-f71jwdzj	61	5	presumably	presumably	RB
cord-277417-f71jwdzj	61	6	because	because	IN
cord-277417-f71jwdzj	61	7	high	high	JJ
cord-277417-f71jwdzj	61	8	virulence	virulence	NN
cord-277417-f71jwdzj	61	9	requires	require	VBZ
cord-277417-f71jwdzj	61	10	a	a	DT
cord-277417-f71jwdzj	61	11	greater	great	JJR
cord-277417-f71jwdzj	61	12	supply	supply	NN
cord-277417-f71jwdzj	61	13	of	of	IN
cord-277417-f71jwdzj	61	14	susceptible	susceptible	JJ
cord-277417-f71jwdzj	61	15	hosts	host	NNS
cord-277417-f71jwdzj	61	16	during	during	IN
cord-277417-f71jwdzj	61	17	the	the	DT
cord-277417-f71jwdzj	61	18	early	early	JJ
cord-277417-f71jwdzj	61	19	stages	stage	NNS
cord-277417-f71jwdzj	61	20	of	of	IN
cord-277417-f71jwdzj	61	21	emergence	emergence	NN
cord-277417-f71jwdzj	61	22	.	.	.
cord-277417-f71jwdzj	62	1	Evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	62	2	biologists	biologist	NNS
cord-277417-f71jwdzj	62	3	have	have	VBP
cord-277417-f71jwdzj	62	4	had	have	VBN
cord-277417-f71jwdzj	62	5	a	a	DT
cord-277417-f71jwdzj	62	6	long	long	JJ
cord-277417-f71jwdzj	62	7	fascination	fascination	NN
cord-277417-f71jwdzj	62	8	with	with	IN
cord-277417-f71jwdzj	62	9	virulence	virulence	NN
cord-277417-f71jwdzj	62	10	[	[	-LRB-
cord-277417-f71jwdzj	62	11	32	32	CD
cord-277417-f71jwdzj	62	12	]	]	-RRB-
cord-277417-f71jwdzj	62	13	[	[	-LRB-
cord-277417-f71jwdzj	62	14	33	33	CD
cord-277417-f71jwdzj	62	15	]	]	-RRB-
cord-277417-f71jwdzj	62	16	[	[	-LRB-
cord-277417-f71jwdzj	62	17	34	34	CD
cord-277417-f71jwdzj	62	18	]	]	-RRB-
cord-277417-f71jwdzj	62	19	[	[	-LRB-
cord-277417-f71jwdzj	62	20	35	35	CD
cord-277417-f71jwdzj	62	21	]	]	-RRB-
cord-277417-f71jwdzj	62	22	[	[	-LRB-
cord-277417-f71jwdzj	62	23	36	36	CD
cord-277417-f71jwdzj	62	24	]	]	-RRB-
cord-277417-f71jwdzj	62	25	[	[	-LRB-
cord-277417-f71jwdzj	62	26	37	37	CD
cord-277417-f71jwdzj	62	27	]	]	-RRB-
cord-277417-f71jwdzj	62	28	.	.	.
cord-277417-f71jwdzj	63	1	Because	because	IN
cord-277417-f71jwdzj	63	2	there	there	EX
cord-277417-f71jwdzj	63	3	is	be	VBZ
cord-277417-f71jwdzj	63	4	a	a	DT
cord-277417-f71jwdzj	63	5	very	very	RB
cord-277417-f71jwdzj	63	6	large	large	JJ
cord-277417-f71jwdzj	63	7	literature	literature	NN
cord-277417-f71jwdzj	63	8	base	base	NN
cord-277417-f71jwdzj	63	9	on	on	IN
cord-277417-f71jwdzj	63	10	this	this	DT
cord-277417-f71jwdzj	63	11	subject	subject	NN
cord-277417-f71jwdzj	63	12	,	,	,
cord-277417-f71jwdzj	63	13	we	-PRON-	PRP
cord-277417-f71jwdzj	63	14	necessarily	necessarily	RB
cord-277417-f71jwdzj	63	15	provide	provide	VBP
cord-277417-f71jwdzj	63	16	only	only	RB
cord-277417-f71jwdzj	63	17	a	a	DT
cord-277417-f71jwdzj	63	18	brief	brief	JJ
cord-277417-f71jwdzj	63	19	overview	overview	NN
cord-277417-f71jwdzj	63	20	here	here	RB
cord-277417-f71jwdzj	63	21	.	.	.
cord-277417-f71jwdzj	64	1	A	a	DT
cord-277417-f71jwdzj	64	2	straightforward	straightforward	JJ
cord-277417-f71jwdzj	64	3	interpretation	interpretation	NN
cord-277417-f71jwdzj	64	4	of	of	IN
cord-277417-f71jwdzj	64	5	virulence	virulence	NN
cord-277417-f71jwdzj	64	6	evolution	evolution	NN
cord-277417-f71jwdzj	64	7	is	be	VBZ
cord-277417-f71jwdzj	64	8	that	that	DT
cord-277417-f71jwdzj	64	9	natural	natural	JJ
cord-277417-f71jwdzj	64	10	selection	selection	NN
cord-277417-f71jwdzj	64	11	will	will	MD
cord-277417-f71jwdzj	64	12	optimize	optimize	VB
cord-277417-f71jwdzj	64	13	the	the	DT
cord-277417-f71jwdzj	64	14	level	level	NN
cord-277417-f71jwdzj	64	15	of	of	IN
cord-277417-f71jwdzj	64	16	virulence	virulence	NN
cord-277417-f71jwdzj	64	17	that	that	WDT
cord-277417-f71jwdzj	64	18	maximizes	maximize	VBZ
cord-277417-f71jwdzj	64	19	pathogen	pathogen	NN
cord-277417-f71jwdzj	64	20	fitness	fitness	NN
cord-277417-f71jwdzj	64	21	,	,	,
cord-277417-f71jwdzj	64	22	expressed	express	VBN
cord-277417-f71jwdzj	64	23	as	as	IN
cord-277417-f71jwdzj	64	24	the	the	DT
cord-277417-f71jwdzj	64	25	basic	basic	JJ
cord-277417-f71jwdzj	64	26	reproductive	reproductive	JJ
cord-277417-f71jwdzj	64	27	number	number	NN
cord-277417-f71jwdzj	64	28	(	(	-LRB-
cord-277417-f71jwdzj	64	29	R	r	NN
cord-277417-f71jwdzj	64	30	0	0	CD
cord-277417-f71jwdzj	64	31	)	)	-RRB-
cord-277417-f71jwdzj	64	32	1	1	CD
cord-277417-f71jwdzj	64	33	,	,	,
cord-277417-f71jwdzj	64	34	although	although	IN
cord-277417-f71jwdzj	64	35	in	in	IN
cord-277417-f71jwdzj	64	36	reality	reality	NN
cord-277417-f71jwdzj	64	37	fitness	fitness	NN
cord-277417-f71jwdzj	64	38	is	be	VBZ
cord-277417-f71jwdzj	64	39	shaped	shape	VBN
cord-277417-f71jwdzj	64	40	by	by	IN
cord-277417-f71jwdzj	64	41	a	a	DT
cord-277417-f71jwdzj	64	42	complex	complex	JJ
cord-277417-f71jwdzj	64	43	set	set	NN
cord-277417-f71jwdzj	64	44	of	of	IN
cord-277417-f71jwdzj	64	45	host	host	NN
cord-277417-f71jwdzj	64	46	-	-	HYPH
cord-277417-f71jwdzj	64	47	pathogen	pathogen	NN
cord-277417-f71jwdzj	64	48	interactions	interaction	NNS
cord-277417-f71jwdzj	64	49	38	38	CD
cord-277417-f71jwdzj	64	50	,	,	,
cord-277417-f71jwdzj	64	51	39	39	CD
cord-277417-f71jwdzj	64	52	.	.	.
cord-277417-f71jwdzj	65	1	Current	current	JJ
cord-277417-f71jwdzj	65	2	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	65	3	theory	theory	NN
cord-277417-f71jwdzj	65	4	tells	tell	VBZ
cord-277417-f71jwdzj	65	5	us	-PRON-	PRP
cord-277417-f71jwdzj	65	6	that	that	IN
cord-277417-f71jwdzj	65	7	when	when	WRB
cord-277417-f71jwdzj	65	8	a	a	DT
cord-277417-f71jwdzj	65	9	virus	virus	NN
cord-277417-f71jwdzj	65	10	jumps	jump	VBZ
cord-277417-f71jwdzj	65	11	to	to	IN
cord-277417-f71jwdzj	65	12	a	a	DT
cord-277417-f71jwdzj	65	13	new	new	JJ
cord-277417-f71jwdzj	65	14	species	specie	NNS
cord-277417-f71jwdzj	65	15	,	,	,
cord-277417-f71jwdzj	65	16	its	-PRON-	PRP$
cord-277417-f71jwdzj	65	17	initial	initial	JJ
cord-277417-f71jwdzj	65	18	virulence	virulence	NN
cord-277417-f71jwdzj	65	19	can	can	MD
cord-277417-f71jwdzj	65	20	vary	vary	VB
cord-277417-f71jwdzj	65	21	from	from	IN
cord-277417-f71jwdzj	65	22	asymptomatic	asymptomatic	JJ
cord-277417-f71jwdzj	65	23	to	to	IN
cord-277417-f71jwdzj	65	24	highly	highly	RB
cord-277417-f71jwdzj	65	25	pathogenic	pathogenic	JJ
cord-277417-f71jwdzj	65	26	,	,	,
cord-277417-f71jwdzj	65	27	and	and	CC
cord-277417-f71jwdzj	65	28	precisely	precisely	RB
cord-277417-f71jwdzj	65	29	where	where	WRB
cord-277417-f71jwdzj	65	30	it	-PRON-	PRP
cord-277417-f71jwdzj	65	31	lies	lie	VBZ
cord-277417-f71jwdzj	65	32	on	on	IN
cord-277417-f71jwdzj	65	33	this	this	DT
cord-277417-f71jwdzj	65	34	virulence	virulence	NN
cord-277417-f71jwdzj	65	35	spectrum	spectrum	NN
cord-277417-f71jwdzj	65	36	is	be	VBZ
cord-277417-f71jwdzj	65	37	difficult	difficult	JJ
cord-277417-f71jwdzj	65	38	to	to	TO
cord-277417-f71jwdzj	65	39	predict	predict	VB
cord-277417-f71jwdzj	65	40	.	.	.
cord-277417-f71jwdzj	66	1	However	however	RB
cord-277417-f71jwdzj	66	2	,	,	,
cord-277417-f71jwdzj	66	3	it	-PRON-	PRP
cord-277417-f71jwdzj	66	4	is	be	VBZ
cord-277417-f71jwdzj	66	5	possible	possible	JJ
cord-277417-f71jwdzj	66	6	that	that	IN
cord-277417-f71jwdzj	66	7	the	the	DT
cord-277417-f71jwdzj	66	8	direction	direction	NN
cord-277417-f71jwdzj	66	9	of	of	IN
cord-277417-f71jwdzj	66	10	virulence	virulence	NN
cord-277417-f71jwdzj	66	11	evolution	evolution	NN
cord-277417-f71jwdzj	66	12	can	can	MD
cord-277417-f71jwdzj	66	13	be	be	VB
cord-277417-f71jwdzj	66	14	anticipated	anticipate	VBN
cord-277417-f71jwdzj	66	15	,	,	,
cord-277417-f71jwdzj	66	16	at	at	IN
cord-277417-f71jwdzj	66	17	least	least	JJS
cord-277417-f71jwdzj	66	18	in	in	IN
cord-277417-f71jwdzj	66	19	part	part	NN
cord-277417-f71jwdzj	66	20	,	,	,
cord-277417-f71jwdzj	66	21	if	if	IN
cord-277417-f71jwdzj	66	22	the	the	DT
cord-277417-f71jwdzj	66	23	key	key	JJ
cord-277417-f71jwdzj	66	24	relationship	relationship	NN
cord-277417-f71jwdzj	66	25	between	between	IN
cord-277417-f71jwdzj	66	26	virulence	virulence	NN
cord-277417-f71jwdzj	66	27	and	and	CC
cord-277417-f71jwdzj	66	28	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	66	29	,	,	,
cord-277417-f71jwdzj	66	30	and	and	CC
cord-277417-f71jwdzj	66	31	hence	hence	RB
cord-277417-f71jwdzj	66	32	fitness	fitness	NN
cord-277417-f71jwdzj	66	33	,	,	,
cord-277417-f71jwdzj	66	34	is	be	VBZ
cord-277417-f71jwdzj	66	35	understood	understand	VBN
cord-277417-f71jwdzj	66	36	.	.	.
cord-277417-f71jwdzj	67	1	Importantly	importantly	RB
cord-277417-f71jwdzj	67	2	,	,	,
cord-277417-f71jwdzj	67	3	there	there	EX
cord-277417-f71jwdzj	67	4	is	be	VBZ
cord-277417-f71jwdzj	67	5	also	also	RB
cord-277417-f71jwdzj	67	6	evidence	evidence	NN
cord-277417-f71jwdzj	67	7	from	from	IN
cord-277417-f71jwdzj	67	8	insect	insect	NN
cord-277417-f71jwdzj	67	9	viruses	virus	NNS
cord-277417-f71jwdzj	67	10	that	that	WDT
cord-277417-f71jwdzj	67	11	host	host	VBP
cord-277417-f71jwdzj	67	12	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	67	13	is	be	VBZ
cord-277417-f71jwdzj	67	14	able	able	JJ
cord-277417-f71jwdzj	67	15	to	to	TO
cord-277417-f71jwdzj	67	16	predict	predict	VB
cord-277417-f71jwdzj	67	17	some	some	DT
cord-277417-f71jwdzj	67	18	aspects	aspect	NNS
cord-277417-f71jwdzj	67	19	of	of	IN
cord-277417-f71jwdzj	67	20	virulence	virulence	NN
cord-277417-f71jwdzj	67	21	evolution	evolution	NN
cord-277417-f71jwdzj	67	22	following	follow	VBG
cord-277417-f71jwdzj	67	23	species	specie	NNS
cord-277417-f71jwdzj	67	24	jumps	jump	VBZ
cord-277417-f71jwdzj	67	25	,	,	,
cord-277417-f71jwdzj	67	26	with	with	IN
cord-277417-f71jwdzj	67	27	related	related	JJ
cord-277417-f71jwdzj	67	28	host	host	NN
cord-277417-f71jwdzj	67	29	species	specie	NNS
cord-277417-f71jwdzj	67	30	tending	tend	VBG
cord-277417-f71jwdzj	67	31	to	to	TO
cord-277417-f71jwdzj	67	32	have	have	VB
cord-277417-f71jwdzj	67	33	similar	similar	JJ
cord-277417-f71jwdzj	67	34	levels	level	NNS
cord-277417-f71jwdzj	67	35	of	of	IN
cord-277417-f71jwdzj	67	36	virulence	virulence	NN
cord-277417-f71jwdzj	67	37	25	25	CD
cord-277417-f71jwdzj	67	38	.	.	.
cord-277417-f71jwdzj	68	1	A	a	DT
cord-277417-f71jwdzj	68	2	commonly	commonly	RB
cord-277417-f71jwdzj	68	3	stated	state	VBN
cord-277417-f71jwdzj	68	4	idea	idea	NN
cord-277417-f71jwdzj	68	5	is	be	VBZ
cord-277417-f71jwdzj	68	6	that	that	IN
cord-277417-f71jwdzj	68	7	there	there	EX
cord-277417-f71jwdzj	68	8	is	be	VBZ
cord-277417-f71jwdzj	68	9	often	often	RB
cord-277417-f71jwdzj	68	10	an	an	DT
cord-277417-f71jwdzj	68	11	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	68	12	trade	trade	NN
cord-277417-f71jwdzj	68	13	-	-	HYPH
cord-277417-f71jwdzj	68	14	off	off	NN
cord-277417-f71jwdzj	68	15	between	between	IN
cord-277417-f71jwdzj	68	16	virulence	virulence	NN
cord-277417-f71jwdzj	68	17	and	and	CC
cord-277417-f71jwdzj	68	18	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	68	19	because	because	IN
cord-277417-f71jwdzj	68	20	intra	intra	JJ
cord-277417-f71jwdzj	68	21	-	-	JJ
cord-277417-f71jwdzj	68	22	host	host	JJ
cord-277417-f71jwdzj	68	23	virus	virus	NN
cord-277417-f71jwdzj	68	24	replication	replication	NN
cord-277417-f71jwdzj	68	25	is	be	VBZ
cord-277417-f71jwdzj	68	26	necessary	necessary	JJ
cord-277417-f71jwdzj	68	27	to	to	TO
cord-277417-f71jwdzj	68	28	facilitate	facilitate	VB
cord-277417-f71jwdzj	68	29	inter	inter	JJ
cord-277417-f71jwdzj	68	30	-	-	JJ
cord-277417-f71jwdzj	68	31	host	host	JJ
cord-277417-f71jwdzj	68	32	transmission	transmission	NN
cord-277417-f71jwdzj	68	33	but	but	CC
cord-277417-f71jwdzj	68	34	may	may	MD
cord-277417-f71jwdzj	68	35	also	also	RB
cord-277417-f71jwdzj	68	36	lead	lead	VB
cord-277417-f71jwdzj	68	37	to	to	IN
cord-277417-f71jwdzj	68	38	disease	disease	NN
cord-277417-f71jwdzj	68	39	,	,	,
cord-277417-f71jwdzj	68	40	and	and	CC
cord-277417-f71jwdzj	68	41	it	-PRON-	PRP
cord-277417-f71jwdzj	68	42	is	be	VBZ
cord-277417-f71jwdzj	68	43	impossible	impossible	JJ
cord-277417-f71jwdzj	68	44	for	for	IN
cord-277417-f71jwdzj	68	45	natural	natural	JJ
cord-277417-f71jwdzj	68	46	selection	selection	NN
cord-277417-f71jwdzj	68	47	to	to	TO
cord-277417-f71jwdzj	68	48	optimize	optimize	VB
cord-277417-f71jwdzj	68	49	all	all	DT
cord-277417-f71jwdzj	68	50	traits	trait	NNS
cord-277417-f71jwdzj	68	51	simultaneously	simultaneously	RB
cord-277417-f71jwdzj	68	52	.	.	.
cord-277417-f71jwdzj	69	1	In	in	IN
cord-277417-f71jwdzj	69	2	the	the	DT
cord-277417-f71jwdzj	69	3	case	case	NN
cord-277417-f71jwdzj	69	4	of	of	IN
cord-277417-f71jwdzj	69	5	MYXV	MYXV	NNP
cord-277417-f71jwdzj	69	6	,	,	,
cord-277417-f71jwdzj	69	7	this	this	DT
cord-277417-f71jwdzj	69	8	trade	trade	NN
cord-277417-f71jwdzj	69	9	-	-	HYPH
cord-277417-f71jwdzj	69	10	off	off	NN
cord-277417-f71jwdzj	69	11	is	be	VBZ
cord-277417-f71jwdzj	69	12	thought	think	VBN
cord-277417-f71jwdzj	69	13	to	to	TO
cord-277417-f71jwdzj	69	14	lead	lead	VB
cord-277417-f71jwdzj	69	15	to	to	IN
cord-277417-f71jwdzj	69	16	'	'	``
cord-277417-f71jwdzj	69	17	intermediate	intermediate	JJ
cord-277417-f71jwdzj	69	18	'	'	''
cord-277417-f71jwdzj	69	19	virulence	virulence	NN
cord-277417-f71jwdzj	69	20	grades	grade	NNS
cord-277417-f71jwdzj	69	21	being	be	VBG
cord-277417-f71jwdzj	69	22	selectively	selectively	RB
cord-277417-f71jwdzj	69	23	advantageous	advantageous	JJ
cord-277417-f71jwdzj	69	24	:	:	:
cord-277417-f71jwdzj	69	25	higher	high	JJR
cord-277417-f71jwdzj	69	26	virulence	virulence	NN
cord-277417-f71jwdzj	69	27	may	may	MD
cord-277417-f71jwdzj	69	28	mean	mean	VB
cord-277417-f71jwdzj	69	29	that	that	IN
cord-277417-f71jwdzj	69	30	the	the	DT
cord-277417-f71jwdzj	69	31	rabbit	rabbit	NN
cord-277417-f71jwdzj	69	32	host	host	NN
cord-277417-f71jwdzj	69	33	dies	die	VBZ
cord-277417-f71jwdzj	69	34	before	before	IN
cord-277417-f71jwdzj	69	35	interhost	interhost	NN
cord-277417-f71jwdzj	69	36	transmission	transmission	NN
cord-277417-f71jwdzj	69	37	,	,	,
cord-277417-f71jwdzj	69	38	whereas	whereas	IN
cord-277417-f71jwdzj	69	39	lower	low	JJR
cord-277417-f71jwdzj	69	40	virulence	virulence	NN
cord-277417-f71jwdzj	69	41	is	be	VBZ
cord-277417-f71jwdzj	69	42	selected	select	VBN
cord-277417-f71jwdzj	69	43	against	against	IN
cord-277417-f71jwdzj	69	44	because	because	IN
cord-277417-f71jwdzj	69	45	it	-PRON-	PRP
cord-277417-f71jwdzj	69	46	does	do	VBZ
cord-277417-f71jwdzj	69	47	not	not	RB
cord-277417-f71jwdzj	69	48	increase	increase	VB
cord-277417-f71jwdzj	69	49	virus	virus	NN
cord-277417-f71jwdzj	69	50	transmission	transmission	NN
cord-277417-f71jwdzj	69	51	rates	rate	NNS
cord-277417-f71jwdzj	69	52	.	.	.
cord-277417-f71jwdzj	70	1	A	a	DT
cord-277417-f71jwdzj	70	2	similar	similar	JJ
cord-277417-f71jwdzj	70	3	trade	trade	NN
cord-277417-f71jwdzj	70	4	-	-	HYPH
cord-277417-f71jwdzj	70	5	off	off	RP
cord-277417-f71jwdzj	70	6	model	model	NN
cord-277417-f71jwdzj	70	7	has	have	VBZ
cord-277417-f71jwdzj	70	8	been	be	VBN
cord-277417-f71jwdzj	70	9	proposed	propose	VBN
cord-277417-f71jwdzj	70	10	to	to	TO
cord-277417-f71jwdzj	70	11	explain	explain	VB
cord-277417-f71jwdzj	70	12	the	the	DT
cord-277417-f71jwdzj	70	13	evolution	evolution	NN
cord-277417-f71jwdzj	70	14	of	of	IN
cord-277417-f71jwdzj	70	15	HIV	HIV	NNP
cord-277417-f71jwdzj	70	16	virulence	virulence	NN
cord-277417-f71jwdzj	70	17	40	40	CD
cord-277417-f71jwdzj	70	18	.	.	.
cord-277417-f71jwdzj	71	1	However	however	RB
cord-277417-f71jwdzj	71	2	,	,	,
cord-277417-f71jwdzj	71	3	many	many	JJ
cord-277417-f71jwdzj	71	4	doubts	doubt	NNS
cord-277417-f71jwdzj	71	5	have	have	VBP
cord-277417-f71jwdzj	71	6	been	be	VBN
cord-277417-f71jwdzj	71	7	raised	raise	VBN
cord-277417-f71jwdzj	71	8	about	about	IN
cord-277417-f71jwdzj	71	9	the	the	DT
cord-277417-f71jwdzj	71	10	general	general	JJ
cord-277417-f71jwdzj	71	11	applicability	applicability	NN
cord-277417-f71jwdzj	71	12	of	of	IN
cord-277417-f71jwdzj	71	13	the	the	DT
cord-277417-f71jwdzj	71	14	trade	trade	NN
cord-277417-f71jwdzj	71	15	-	-	HYPH
cord-277417-f71jwdzj	71	16	off	off	RP
cord-277417-f71jwdzj	71	17	model	model	NN
cord-277417-f71jwdzj	71	18	35	35	CD
cord-277417-f71jwdzj	71	19	,	,	,
cord-277417-f71jwdzj	71	20	[	[	-LRB-
cord-277417-f71jwdzj	71	21	41	41	CD
cord-277417-f71jwdzj	71	22	]	]	-RRB-
cord-277417-f71jwdzj	71	23	[	[	-LRB-
cord-277417-f71jwdzj	71	24	42	42	CD
cord-277417-f71jwdzj	71	25	]	]	-RRB-
cord-277417-f71jwdzj	71	26	[	[	-LRB-
cord-277417-f71jwdzj	71	27	43	43	CD
cord-277417-f71jwdzj	71	28	]	]	-RRB-
cord-277417-f71jwdzj	71	29	,	,	,
cord-277417-f71jwdzj	71	30	virus	virus	NN
cord-277417-f71jwdzj	71	31	fitness	fitness	NN
cord-277417-f71jwdzj	71	32	will	will	MD
cord-277417-f71jwdzj	71	33	be	be	VB
cord-277417-f71jwdzj	71	34	affected	affect	VBN
cord-277417-f71jwdzj	71	35	by	by	IN
cord-277417-f71jwdzj	71	36	traits	trait	NNS
cord-277417-f71jwdzj	71	37	other	other	JJ
cord-277417-f71jwdzj	71	38	than	than	IN
cord-277417-f71jwdzj	71	39	virulence	virulence	NN
cord-277417-f71jwdzj	71	40	and	and	CC
cord-277417-f71jwdzj	71	41	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	71	42	39	39	CD
cord-277417-f71jwdzj	71	43	,	,	,
cord-277417-f71jwdzj	71	44	41	41	CD
cord-277417-f71jwdzj	71	45	,	,	,
cord-277417-f71jwdzj	71	46	44	44	CD
cord-277417-f71jwdzj	71	47	,	,	,
cord-277417-f71jwdzj	71	48	contrary	contrary	JJ
cord-277417-f71jwdzj	71	49	results	result	NNS
cord-277417-f71jwdzj	71	50	have	have	VBP
cord-277417-f71jwdzj	71	51	been	be	VBN
cord-277417-f71jwdzj	71	52	observed	observe	VBN
cord-277417-f71jwdzj	71	53	in	in	IN
cord-277417-f71jwdzj	71	54	experimental	experimental	JJ
cord-277417-f71jwdzj	71	55	studies	study	NNS
cord-277417-f71jwdzj	71	56	45	45	CD
cord-277417-f71jwdzj	71	57	and	and	CC
cord-277417-f71jwdzj	71	58	relatively	relatively	RB
cord-277417-f71jwdzj	71	59	little	little	JJ
cord-277417-f71jwdzj	71	60	is	be	VBZ
cord-277417-f71jwdzj	71	61	known	know	VBN
cord-277417-f71jwdzj	71	62	about	about	IN
cord-277417-f71jwdzj	71	63	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	71	64	trade	trade	NN
cord-277417-f71jwdzj	71	65	-	-	HYPH
cord-277417-f71jwdzj	71	66	offs	off	NNS
cord-277417-f71jwdzj	71	67	in	in	IN
cord-277417-f71jwdzj	71	68	nature	nature	NN
cord-277417-f71jwdzj	71	69	.	.	.
cord-277417-f71jwdzj	72	1	For	for	IN
cord-277417-f71jwdzj	72	2	example	example	NN
cord-277417-f71jwdzj	72	3	,	,	,
cord-277417-f71jwdzj	72	4	in	in	IN
cord-277417-f71jwdzj	72	5	the	the	DT
cord-277417-f71jwdzj	72	6	case	case	NN
cord-277417-f71jwdzj	72	7	of	of	IN
cord-277417-f71jwdzj	72	8	the	the	DT
cord-277417-f71jwdzj	72	9	second	second	JJ
cord-277417-f71jwdzj	72	10	virus	virus	NN
cord-277417-f71jwdzj	72	11	released	release	VBN
cord-277417-f71jwdzj	72	12	as	as	IN
cord-277417-f71jwdzj	72	13	a	a	DT
cord-277417-f71jwdzj	72	14	biocontrol	biocontrol	NN
cord-277417-f71jwdzj	72	15	against	against	IN
cord-277417-f71jwdzj	72	16	European	european	JJ
cord-277417-f71jwdzj	72	17	rabbits	rabbit	NNS
cord-277417-f71jwdzj	72	18	in	in	IN
cord-277417-f71jwdzj	72	19	Australia	Australia	NNP
cord-277417-f71jwdzj	72	20	-rabbit	-rabbit	HYPH
cord-277417-f71jwdzj	72	21	haemorrhagic	haemorrhagic	JJ
cord-277417-f71jwdzj	72	22	disease	disease	NN
cord-277417-f71jwdzj	72	23	virus	virus	NN
cord-277417-f71jwdzj	72	24	(	(	-LRB-
cord-277417-f71jwdzj	72	25	RHDV	RHDV	NNP
cord-277417-f71jwdzj	72	26	)	)	-RRB-
cord-277417-f71jwdzj	73	1	-there	-there	NN
cord-277417-f71jwdzj	73	2	is	be	VBZ
cord-277417-f71jwdzj	73	3	evidence	evidence	NN
cord-277417-f71jwdzj	73	4	that	that	IN
cord-277417-f71jwdzj	73	5	virulence	virulence	NN
cord-277417-f71jwdzj	73	6	has	have	VBZ
cord-277417-f71jwdzj	73	7	increased	increase	VBN
cord-277417-f71jwdzj	73	8	through	through	IN
cord-277417-f71jwdzj	73	9	time	time	NN
cord-277417-f71jwdzj	73	10	,	,	,
cord-277417-f71jwdzj	73	11	probably	probably	RB
cord-277417-f71jwdzj	73	12	because	because	IN
cord-277417-f71jwdzj	73	13	virus	virus	NN
cord-277417-f71jwdzj	73	14	transmission	transmission	NN
cord-277417-f71jwdzj	73	15	often	often	RB
cord-277417-f71jwdzj	73	16	occurs	occur	VBZ
cord-277417-f71jwdzj	73	17	through	through	IN
cord-277417-f71jwdzj	73	18	blow	blow	NN
cord-277417-f71jwdzj	73	19	flies	fly	NNS
cord-277417-f71jwdzj	73	20	that	that	WDT
cord-277417-f71jwdzj	73	21	feed	feed	VBP
cord-277417-f71jwdzj	73	22	on	on	IN
cord-277417-f71jwdzj	73	23	animal	animal	NN
cord-277417-f71jwdzj	73	24	carcasses	carcass	NNS
cord-277417-f71jwdzj	73	25	,	,	,
cord-277417-f71jwdzj	73	26	making	make	VBG
cord-277417-f71jwdzj	73	27	host	host	NN
cord-277417-f71jwdzj	73	28	death	death	NN
cord-277417-f71jwdzj	73	29	selectively	selectively	RB
cord-277417-f71jwdzj	73	30	favourable	favourable	JJ
cord-277417-f71jwdzj	73	31	46	46	CD
cord-277417-f71jwdzj	73	32	.	.	.
cord-277417-f71jwdzj	74	1	Similarly	similarly	RB
cord-277417-f71jwdzj	74	2	,	,	,
cord-277417-f71jwdzj	74	3	experimental	experimental	JJ
cord-277417-f71jwdzj	74	4	studies	study	NNS
cord-277417-f71jwdzj	74	5	of	of	IN
cord-277417-f71jwdzj	74	6	plant	plant	NN
cord-277417-f71jwdzj	74	7	RNA	RNA	NNP
cord-277417-f71jwdzj	74	8	viruses	virus	NNS
cord-277417-f71jwdzj	74	9	have	have	VBP
cord-277417-f71jwdzj	74	10	shown	show	VBN
cord-277417-f71jwdzj	74	11	that	that	IN
cord-277417-f71jwdzj	74	12	high	high	JJ
cord-277417-f71jwdzj	74	13	virulence	virulence	NN
cord-277417-f71jwdzj	74	14	does	do	VBZ
cord-277417-f71jwdzj	74	15	not	not	RB
cord-277417-f71jwdzj	74	16	necessarily	necessarily	RB
cord-277417-f71jwdzj	74	17	impede	impede	VB
cord-277417-f71jwdzj	74	18	host	host	NN
cord-277417-f71jwdzj	74	19	adaptation	adaptation	NN
cord-277417-f71jwdzj	74	20	47	47	CD
cord-277417-f71jwdzj	74	21	and	and	CC
cord-277417-f71jwdzj	74	22	,	,	,
cord-277417-f71jwdzj	74	23	in	in	IN
cord-277417-f71jwdzj	74	24	the	the	DT
cord-277417-f71jwdzj	74	25	case	case	NN
cord-277417-f71jwdzj	74	26	of	of	IN
cord-277417-f71jwdzj	74	27	malaria	malaria	NN
cord-277417-f71jwdzj	74	28	,	,	,
cord-277417-f71jwdzj	74	29	higher	high	JJR
cord-277417-f71jwdzj	74	30	virulence	virulence	NN
cord-277417-f71jwdzj	74	31	www.nature.com/nrg	www.nature.com/nrg	NFP
cord-277417-f71jwdzj	74	32	Reverse	Reverse	NNP
cord-277417-f71jwdzj	74	33	genetics	genetic	NNS
cord-277417-f71jwdzj	74	34	experimental	experimental	JJ
cord-277417-f71jwdzj	74	35	method	method	NN
cord-277417-f71jwdzj	74	36	used	use	VBN
cord-277417-f71jwdzj	74	37	to	to	TO
cord-277417-f71jwdzj	74	38	identify	identify	VB
cord-277417-f71jwdzj	74	39	gene	gene	NN
cord-277417-f71jwdzj	74	40	function	function	NN
cord-277417-f71jwdzj	74	41	by	by	IN
cord-277417-f71jwdzj	74	42	modifying	modify	VBG
cord-277417-f71jwdzj	74	43	the	the	DT
cord-277417-f71jwdzj	74	44	sequence	sequence	NN
cord-277417-f71jwdzj	74	45	of	of	IN
cord-277417-f71jwdzj	74	46	a	a	DT
cord-277417-f71jwdzj	74	47	target	target	NN
cord-277417-f71jwdzj	74	48	gene	gene	NN
cord-277417-f71jwdzj	74	49	and	and	CC
cord-277417-f71jwdzj	74	50	analysing	analyse	VBG
cord-277417-f71jwdzj	74	51	its	-PRON-	PRP$
cord-277417-f71jwdzj	74	52	phenotypic	phenotypic	JJ
cord-277417-f71jwdzj	74	53	consequences	consequence	NNS
cord-277417-f71jwdzj	74	54	.	.	.
cord-277417-f71jwdzj	75	1	The	the	DT
cord-277417-f71jwdzj	75	2	inference	inference	NN
cord-277417-f71jwdzj	75	3	of	of	IN
cord-277417-f71jwdzj	75	4	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	75	5	patterns	pattern	NNS
cord-277417-f71jwdzj	75	6	and/or	and/or	CC
cord-277417-f71jwdzj	75	7	processes	process	NNS
cord-277417-f71jwdzj	75	8	through	through	IN
cord-277417-f71jwdzj	75	9	the	the	DT
cord-277417-f71jwdzj	75	10	comparison	comparison	NN
cord-277417-f71jwdzj	75	11	of	of	IN
cord-277417-f71jwdzj	75	12	whole	whole	JJ
cord-277417-f71jwdzj	75	13	-	-	HYPH
cord-277417-f71jwdzj	75	14	genome	genome	NN
cord-277417-f71jwdzj	75	15	sequences	sequence	NNS
cord-277417-f71jwdzj	75	16	.	.	.
cord-277417-f71jwdzj	76	1	Depiction	depiction	NN
cord-277417-f71jwdzj	76	2	of	of	IN
cord-277417-f71jwdzj	76	3	the	the	DT
cord-277417-f71jwdzj	76	4	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	76	5	history	history	NN
cord-277417-f71jwdzj	76	6	of	of	IN
cord-277417-f71jwdzj	76	7	a	a	DT
cord-277417-f71jwdzj	76	8	genetically	genetically	RB
cord-277417-f71jwdzj	76	9	related	relate	VBN
cord-277417-f71jwdzj	76	10	group	group	NN
cord-277417-f71jwdzj	76	11	of	of	IN
cord-277417-f71jwdzj	76	12	organisms	organism	NNS
cord-277417-f71jwdzj	76	13	.	.	.
cord-277417-f71jwdzj	77	1	Contains	contain	VBZ
cord-277417-f71jwdzj	77	2	branches	branch	NNS
cord-277417-f71jwdzj	77	3	and	and	CC
cord-277417-f71jwdzj	77	4	nodes	node	NNS
cord-277417-f71jwdzj	77	5	.	.	.
cord-277417-f71jwdzj	78	1	Infectious	infectious	JJ
cord-277417-f71jwdzj	78	2	diseases	disease	NNS
cord-277417-f71jwdzj	78	3	that	that	WDT
cord-277417-f71jwdzj	78	4	have	have	VBP
cord-277417-f71jwdzj	78	5	recently	recently	RB
cord-277417-f71jwdzj	78	6	appeared	appear	VBN
cord-277417-f71jwdzj	78	7	in	in	IN
cord-277417-f71jwdzj	78	8	populations	population	NNS
cord-277417-f71jwdzj	78	9	or	or	CC
cord-277417-f71jwdzj	78	10	known	know	VBN
cord-277417-f71jwdzj	78	11	diseases	disease	NNS
cord-277417-f71jwdzj	78	12	that	that	WDT
cord-277417-f71jwdzj	78	13	are	be	VBP
cord-277417-f71jwdzj	78	14	rapidly	rapidly	RB
cord-277417-f71jwdzj	78	15	increasing	increase	VBG
cord-277417-f71jwdzj	78	16	in	in	IN
cord-277417-f71jwdzj	78	17	incidence	incidence	NN
cord-277417-f71jwdzj	78	18	or	or	CC
cord-277417-f71jwdzj	78	19	geographic	geographic	JJ
cord-277417-f71jwdzj	78	20	range	range	NN
cord-277417-f71jwdzj	78	21	.	.	.
cord-277417-f71jwdzj	79	1	(	(	-LRB-
cord-277417-f71jwdzj	79	2	R	r	NN
cord-277417-f71jwdzj	79	3	0	0	CD
cord-277417-f71jwdzj	79	4	)	)	-RRB-
cord-277417-f71jwdzj	79	5	.	.	.
cord-277417-f71jwdzj	80	1	Represents	represent	VBZ
cord-277417-f71jwdzj	80	2	the	the	DT
cord-277417-f71jwdzj	80	3	number	number	NN
cord-277417-f71jwdzj	80	4	of	of	IN
cord-277417-f71jwdzj	80	5	secondary	secondary	JJ
cord-277417-f71jwdzj	80	6	infections	infection	NNS
cord-277417-f71jwdzj	80	7	caused	cause	VBN
cord-277417-f71jwdzj	80	8	by	by	IN
cord-277417-f71jwdzj	80	9	an	an	DT
cord-277417-f71jwdzj	80	10	infectious	infectious	JJ
cord-277417-f71jwdzj	80	11	host	host	NN
cord-277417-f71jwdzj	80	12	in	in	IN
cord-277417-f71jwdzj	80	13	an	an	DT
cord-277417-f71jwdzj	80	14	entirely	entirely	RB
cord-277417-f71jwdzj	80	15	susceptible	susceptible	JJ
cord-277417-f71jwdzj	80	16	population	population	NN
cord-277417-f71jwdzj	80	17	.	.	.
cord-277417-f71jwdzj	81	1	occurs	occur	VBZ
cord-277417-f71jwdzj	81	2	when	when	WRB
cord-277417-f71jwdzj	81	3	a	a	DT
cord-277417-f71jwdzj	81	4	change	change	NN
cord-277417-f71jwdzj	81	5	in	in	IN
cord-277417-f71jwdzj	81	6	one	one	CD
cord-277417-f71jwdzj	81	7	trait	trait	NN
cord-277417-f71jwdzj	81	8	increases	increase	VBZ
cord-277417-f71jwdzj	81	9	fitness	fitness	NN
cord-277417-f71jwdzj	81	10	but	but	CC
cord-277417-f71jwdzj	81	11	simultaneously	simultaneously	RB
cord-277417-f71jwdzj	81	12	reduces	reduce	VBZ
cord-277417-f71jwdzj	81	13	fitness	fitness	NN
cord-277417-f71jwdzj	81	14	because	because	IN
cord-277417-f71jwdzj	81	15	of	of	IN
cord-277417-f71jwdzj	81	16	its	-PRON-	PRP$
cord-277417-f71jwdzj	81	17	impact	impact	NN
cord-277417-f71jwdzj	81	18	on	on	IN
cord-277417-f71jwdzj	81	19	another	another	DT
cord-277417-f71jwdzj	81	20	trait	trait	NN
cord-277417-f71jwdzj	81	21	,	,	,
cord-277417-f71jwdzj	81	22	thereby	thereby	RB
cord-277417-f71jwdzj	81	23	preventing	prevent	VBG
cord-277417-f71jwdzj	81	24	the	the	DT
cord-277417-f71jwdzj	81	25	organism	organism	NN
cord-277417-f71jwdzj	81	26	from	from	IN
cord-277417-f71jwdzj	81	27	optimizing	optimize	VBG
cord-277417-f71jwdzj	81	28	both	both	DT
cord-277417-f71jwdzj	81	29	traits	trait	NNS
cord-277417-f71jwdzj	81	30	.	.	.
cord-277417-f71jwdzj	82	1	was	be	VBD
cord-277417-f71jwdzj	82	2	shown	show	VBN
cord-277417-f71jwdzj	82	3	to	to	TO
cord-277417-f71jwdzj	82	4	provide	provide	VB
cord-277417-f71jwdzj	82	5	the	the	DT
cord-277417-f71jwdzj	82	6	Plasmodium	Plasmodium	NNP
cord-277417-f71jwdzj	82	7	parasites	parasite	NNS
cord-277417-f71jwdzj	82	8	with	with	IN
cord-277417-f71jwdzj	82	9	a	a	DT
cord-277417-f71jwdzj	82	10	competitive	competitive	JJ
cord-277417-f71jwdzj	82	11	advantage	advantage	NN
cord-277417-f71jwdzj	82	12	within	within	IN
cord-277417-f71jwdzj	82	13	hosts	host	NNS
cord-277417-f71jwdzj	82	14	48	48	CD
cord-277417-f71jwdzj	82	15	.	.	.
cord-277417-f71jwdzj	83	1	Other	other	JJ
cord-277417-f71jwdzj	83	2	factors	factor	NNS
cord-277417-f71jwdzj	83	3	in	in	IN
cord-277417-f71jwdzj	83	4	addition	addition	NN
cord-277417-f71jwdzj	83	5	to	to	IN
cord-277417-f71jwdzj	83	6	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	83	7	trade	trade	NN
cord-277417-f71jwdzj	83	8	-	-	HYPH
cord-277417-f71jwdzj	83	9	offs	off	NNS
cord-277417-f71jwdzj	83	10	can	can	MD
cord-277417-f71jwdzj	83	11	shape	shape	VB
cord-277417-f71jwdzj	83	12	the	the	DT
cord-277417-f71jwdzj	83	13	level	level	NN
cord-277417-f71jwdzj	83	14	of	of	IN
cord-277417-f71jwdzj	83	15	virulence	virulence	NN
cord-277417-f71jwdzj	83	16	in	in	IN
cord-277417-f71jwdzj	83	17	an	an	DT
cord-277417-f71jwdzj	83	18	emerging	emerge	VBG
cord-277417-f71jwdzj	83	19	virus	virus	NN
cord-277417-f71jwdzj	83	20	.	.	.
cord-277417-f71jwdzj	84	1	For	for	IN
cord-277417-f71jwdzj	84	2	example	example	NN
cord-277417-f71jwdzj	84	3	,	,	,
cord-277417-f71jwdzj	84	4	'	'	''
cord-277417-f71jwdzj	84	5	short	short	JJ
cord-277417-f71jwdzj	84	6	-	-	HYPH
cord-277417-f71jwdzj	84	7	sighted	sighted	JJ
cord-277417-f71jwdzj	84	8	'	'	POS
cord-277417-f71jwdzj	84	9	virulence	virulence	NN
cord-277417-f71jwdzj	84	10	evolution	evolution	NN
cord-277417-f71jwdzj	84	11	within	within	IN
cord-277417-f71jwdzj	84	12	a	a	DT
cord-277417-f71jwdzj	84	13	single	single	JJ
cord-277417-f71jwdzj	84	14	host	host	NN
cord-277417-f71jwdzj	84	15	may	may	MD
cord-277417-f71jwdzj	84	16	be	be	VB
cord-277417-f71jwdzj	84	17	detrimental	detrimental	JJ
cord-277417-f71jwdzj	84	18	for	for	IN
cord-277417-f71jwdzj	84	19	inter	inter	JJ
cord-277417-f71jwdzj	84	20	-	-	JJ
cord-277417-f71jwdzj	84	21	host	host	JJ
cord-277417-f71jwdzj	84	22	transmission	transmission	NN
cord-277417-f71jwdzj	84	23	49	49	CD
cord-277417-f71jwdzj	84	24	,	,	,
cord-277417-f71jwdzj	84	25	and	and	CC
cord-277417-f71jwdzj	84	26	newly	newly	RB
cord-277417-f71jwdzj	84	27	emerged	emerge	VBN
cord-277417-f71jwdzj	84	28	'	'	``
cord-277417-f71jwdzj	84	29	spillover	spillover	NN
cord-277417-f71jwdzj	84	30	'	'	''
cord-277417-f71jwdzj	84	31	infections	infection	NNS
cord-277417-f71jwdzj	84	32	that	that	WDT
cord-277417-f71jwdzj	84	33	have	have	VBP
cord-277417-f71jwdzj	84	34	experienced	experience	VBN
cord-277417-f71jwdzj	84	35	only	only	RB
cord-277417-f71jwdzj	84	36	a	a	DT
cord-277417-f71jwdzj	84	37	limited	limited	JJ
cord-277417-f71jwdzj	84	38	number	number	NN
cord-277417-f71jwdzj	84	39	of	of	IN
cord-277417-f71jwdzj	84	40	transmission	transmission	NN
cord-277417-f71jwdzj	84	41	events	event	NNS
cord-277417-f71jwdzj	84	42	are	be	VBP
cord-277417-f71jwdzj	84	43	likely	likely	JJ
cord-277417-f71jwdzj	84	44	to	to	TO
cord-277417-f71jwdzj	84	45	have	have	VB
cord-277417-f71jwdzj	84	46	virulence	virulence	NN
cord-277417-f71jwdzj	84	47	levels	level	NNS
cord-277417-f71jwdzj	84	48	that	that	WDT
cord-277417-f71jwdzj	84	49	have	have	VBP
cord-277417-f71jwdzj	84	50	not	not	RB
cord-277417-f71jwdzj	84	51	yet	yet	RB
cord-277417-f71jwdzj	84	52	been	be	VBN
cord-277417-f71jwdzj	84	53	optimized	optimize	VBN
cord-277417-f71jwdzj	84	54	for	for	IN
cord-277417-f71jwdzj	84	55	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	84	56	by	by	IN
cord-277417-f71jwdzj	84	57	natural	natural	JJ
cord-277417-f71jwdzj	84	58	selection	selection	NN
cord-277417-f71jwdzj	84	59	50	50	CD
cord-277417-f71jwdzj	84	60	.	.	.
cord-277417-f71jwdzj	85	1	Accordingly	accordingly	RB
cord-277417-f71jwdzj	85	2	,	,	,
cord-277417-f71jwdzj	85	3	for	for	IN
cord-277417-f71jwdzj	85	4	spillover	spillover	NN
cord-277417-f71jwdzj	85	5	infections	infection	NNS
cord-277417-f71jwdzj	85	6	,	,	,
cord-277417-f71jwdzj	85	7	ongoing	ongoing	JJ
cord-277417-f71jwdzj	85	8	transmission	transmission	NN
cord-277417-f71jwdzj	85	9	may	may	MD
cord-277417-f71jwdzj	85	10	be	be	VB
cord-277417-f71jwdzj	85	11	largely	largely	RB
cord-277417-f71jwdzj	85	12	at	at	IN
cord-277417-f71jwdzj	85	13	the	the	DT
cord-277417-f71jwdzj	85	14	mercy	mercy	NN
cord-277417-f71jwdzj	85	15	of	of	IN
cord-277417-f71jwdzj	85	16	random	random	JJ
cord-277417-f71jwdzj	85	17	drift	drift	NN
cord-277417-f71jwdzj	85	18	effects	effect	NNS
cord-277417-f71jwdzj	85	19	,	,	,
cord-277417-f71jwdzj	85	20	including	include	VBG
cord-277417-f71jwdzj	85	21	the	the	DT
cord-277417-f71jwdzj	85	22	severe	severe	JJ
cord-277417-f71jwdzj	85	23	population	population	NN
cord-277417-f71jwdzj	85	24	bottlenecks	bottleneck	NNS
cord-277417-f71jwdzj	85	25	that	that	WDT
cord-277417-f71jwdzj	85	26	routinely	routinely	RB
cord-277417-f71jwdzj	85	27	accompany	accompany	VBP
cord-277417-f71jwdzj	85	28	such	such	JJ
cord-277417-f71jwdzj	85	29	events	event	NNS
cord-277417-f71jwdzj	85	30	51	51	CD
cord-277417-f71jwdzj	85	31	.	.	.
cord-277417-f71jwdzj	86	1	Finally	finally	RB
cord-277417-f71jwdzj	86	2	,	,	,
cord-277417-f71jwdzj	86	3	it	-PRON-	PRP
cord-277417-f71jwdzj	86	4	is	be	VBZ
cord-277417-f71jwdzj	86	5	possible	possible	JJ
cord-277417-f71jwdzj	86	6	that	that	DT
cord-277417-f71jwdzj	86	7	virulence	virulence	NN
cord-277417-f71jwdzj	86	8	may	may	MD
cord-277417-f71jwdzj	86	9	sometimes	sometimes	RB
cord-277417-f71jwdzj	86	10	simply	simply	RB
cord-277417-f71jwdzj	86	11	be	be	VB
cord-277417-f71jwdzj	86	12	a	a	DT
cord-277417-f71jwdzj	86	13	coincidental	coincidental	JJ
cord-277417-f71jwdzj	86	14	by	by	IN
cord-277417-f71jwdzj	86	15	-	-	HYPH
cord-277417-f71jwdzj	86	16	product	product	NN
cord-277417-f71jwdzj	86	17	of	of	IN
cord-277417-f71jwdzj	86	18	selection	selection	NN
cord-277417-f71jwdzj	86	19	for	for	IN
cord-277417-f71jwdzj	86	20	another	another	DT
cord-277417-f71jwdzj	86	21	trait	trait	NN
cord-277417-f71jwdzj	86	22	or	or	CC
cord-277417-f71jwdzj	86	23	selection	selection	NN
cord-277417-f71jwdzj	86	24	for	for	IN
cord-277417-f71jwdzj	86	25	transmission	transmission	NN
cord-277417-f71jwdzj	86	26	in	in	IN
cord-277417-f71jwdzj	86	27	another	another	DT
cord-277417-f71jwdzj	86	28	species	species	NN
cord-277417-f71jwdzj	86	29	.	.	.
cord-277417-f71jwdzj	87	1	Theory	theory	NN
cord-277417-f71jwdzj	87	2	therefore	therefore	RB
cord-277417-f71jwdzj	87	3	tells	tell	VBZ
cord-277417-f71jwdzj	87	4	us	-PRON-	PRP
cord-277417-f71jwdzj	87	5	that	that	IN
cord-277417-f71jwdzj	87	6	natural	natural	JJ
cord-277417-f71jwdzj	87	7	selection	selection	NN
cord-277417-f71jwdzj	87	8	can	can	MD
cord-277417-f71jwdzj	87	9	increase	increase	VB
cord-277417-f71jwdzj	87	10	or	or	CC
cord-277417-f71jwdzj	87	11	decrease	decrease	VB
cord-277417-f71jwdzj	87	12	pathogen	pathogen	NN
cord-277417-f71jwdzj	87	13	virulence	virulence	NN
cord-277417-f71jwdzj	87	14	,	,	,
cord-277417-f71jwdzj	87	15	depending	depend	VBG
cord-277417-f71jwdzj	87	16	on	on	IN
cord-277417-f71jwdzj	87	17	the	the	DT
cord-277417-f71jwdzj	87	18	particular	particular	JJ
cord-277417-f71jwdzj	87	19	combination	combination	NN
cord-277417-f71jwdzj	87	20	between	between	IN
cord-277417-f71jwdzj	87	21	host	host	NN
cord-277417-f71jwdzj	87	22	,	,	,
cord-277417-f71jwdzj	87	23	virus	virus	NN
cord-277417-f71jwdzj	87	24	and	and	CC
cord-277417-f71jwdzj	87	25	environment	environment	NN
cord-277417-f71jwdzj	87	26	1	1	CD
cord-277417-f71jwdzj	87	27	,	,	,
cord-277417-f71jwdzj	87	28	32	32	CD
cord-277417-f71jwdzj	87	29	,	,	,
cord-277417-f71jwdzj	87	30	33	33	CD
cord-277417-f71jwdzj	87	31	,	,	,
cord-277417-f71jwdzj	87	32	37	37	CD
cord-277417-f71jwdzj	87	33	,	,	,
cord-277417-f71jwdzj	87	34	41	41	CD
cord-277417-f71jwdzj	87	35	,	,	,
cord-277417-f71jwdzj	87	36	52	52	CD
cord-277417-f71jwdzj	87	37	,	,	,
cord-277417-f71jwdzj	87	38	53	53	CD
cord-277417-f71jwdzj	87	39	.	.	.
cord-277417-f71jwdzj	88	1	Although	although	IN
cord-277417-f71jwdzj	88	2	providing	provide	VBG
cord-277417-f71jwdzj	88	3	a	a	DT
cord-277417-f71jwdzj	88	4	useful	useful	JJ
cord-277417-f71jwdzj	88	5	framework	framework	NN
cord-277417-f71jwdzj	88	6	,	,	,
cord-277417-f71jwdzj	88	7	theory	theory	NN
cord-277417-f71jwdzj	88	8	can	can	MD
cord-277417-f71jwdzj	88	9	provide	provide	VB
cord-277417-f71jwdzj	88	10	only	only	RB
cord-277417-f71jwdzj	88	11	useful	useful	JJ
cord-277417-f71jwdzj	88	12	generalities	generality	NNS
cord-277417-f71jwdzj	88	13	because	because	IN
cord-277417-f71jwdzj	88	14	the	the	DT
cord-277417-f71jwdzj	88	15	relevant	relevant	JJ
cord-277417-f71jwdzj	88	16	factors	factor	NNS
cord-277417-f71jwdzj	88	17	vary	vary	VBP
cord-277417-f71jwdzj	88	18	substantially	substantially	RB
cord-277417-f71jwdzj	88	19	and	and	CC
cord-277417-f71jwdzj	88	20	need	need	VBP
cord-277417-f71jwdzj	88	21	to	to	TO
cord-277417-f71jwdzj	88	22	be	be	VB
cord-277417-f71jwdzj	88	23	assessed	assess	VBN
cord-277417-f71jwdzj	88	24	on	on	IN
cord-277417-f71jwdzj	88	25	a	a	DT
cord-277417-f71jwdzj	88	26	case	case	NN
cord-277417-f71jwdzj	88	27	-	-	HYPH
cord-277417-f71jwdzj	88	28	by	by	IN
cord-277417-f71jwdzj	88	29	-	-	HYPH
cord-277417-f71jwdzj	88	30	case	case	NN
cord-277417-f71jwdzj	88	31	basis	basis	NN
cord-277417-f71jwdzj	88	32	.	.	.
cord-277417-f71jwdzj	89	1	Virulence	virulence	NN
cord-277417-f71jwdzj	89	2	evolution	evolution	NN
cord-277417-f71jwdzj	89	3	could	could	MD
cord-277417-f71jwdzj	89	4	,	,	,
cord-277417-f71jwdzj	89	5	however	however	RB
cord-277417-f71jwdzj	89	6	,	,	,
cord-277417-f71jwdzj	89	7	be	be	VB
cord-277417-f71jwdzj	89	8	better	well	RBR
cord-277417-f71jwdzj	89	9	understood	understand	VBN
cord-277417-f71jwdzj	89	10	if	if	IN
cord-277417-f71jwdzj	89	11	its	-PRON-	PRP$
cord-277417-f71jwdzj	89	12	genomic	genomic	JJ
cord-277417-f71jwdzj	89	13	basis	basis	NN
cord-277417-f71jwdzj	89	14	were	be	VBD
cord-277417-f71jwdzj	89	15	known	know	VBN
cord-277417-f71jwdzj	89	16	.	.	.
cord-277417-f71jwdzj	90	1	Phylogenetic	phylogenetic	JJ
cord-277417-f71jwdzj	90	2	studies	study	NNS
cord-277417-f71jwdzj	90	3	of	of	IN
cord-277417-f71jwdzj	90	4	viruses	virus	NNS
cord-277417-f71jwdzj	90	5	,	,	,
cord-277417-f71jwdzj	90	6	including	include	VBG
cord-277417-f71jwdzj	90	7	those	those	DT
cord-277417-f71jwdzj	90	8	that	that	WDT
cord-277417-f71jwdzj	90	9	consider	consider	VBP
cord-277417-f71jwdzj	90	10	whole	whole	JJ
cord-277417-f71jwdzj	90	11	-	-	HYPH
cord-277417-f71jwdzj	90	12	genome	genome	NN
cord-277417-f71jwdzj	90	13	sequences	sequence	NNS
cord-277417-f71jwdzj	90	14	,	,	,
cord-277417-f71jwdzj	90	15	are	be	VBP
cord-277417-f71jwdzj	90	16	commonplace	commonplace	JJ
cord-277417-f71jwdzj	90	17	and	and	CC
cord-277417-f71jwdzj	90	18	are	be	VBP
cord-277417-f71jwdzj	90	19	often	often	RB
cord-277417-f71jwdzj	90	20	used	use	VBN
cord-277417-f71jwdzj	90	21	to	to	TO
cord-277417-f71jwdzj	90	22	understand	understand	VB
cord-277417-f71jwdzj	90	23	a	a	DT
cord-277417-f71jwdzj	90	24	variety	variety	NN
cord-277417-f71jwdzj	90	25	of	of	IN
cord-277417-f71jwdzj	90	26	aspects	aspect	NNS
cord-277417-f71jwdzj	90	27	of	of	IN
cord-277417-f71jwdzj	90	28	virus	virus	NN
cord-277417-f71jwdzj	90	29	evolution	evolution	NN
cord-277417-f71jwdzj	90	30	.	.	.
cord-277417-f71jwdzj	91	1	In	in	IN
cord-277417-f71jwdzj	91	2	particular	particular	JJ
cord-277417-f71jwdzj	91	3	,	,	,
cord-277417-f71jwdzj	91	4	virus	virus	NN
cord-277417-f71jwdzj	91	5	phylogenies	phylogeny	NNS
cord-277417-f71jwdzj	91	6	are	be	VBP
cord-277417-f71jwdzj	91	7	being	be	VBG
cord-277417-f71jwdzj	91	8	increasingly	increasingly	RB
cord-277417-f71jwdzj	91	9	used	use	VBN
cord-277417-f71jwdzj	91	10	to	to	TO
cord-277417-f71jwdzj	91	11	understand	understand	VB
cord-277417-f71jwdzj	91	12	the	the	DT
cord-277417-f71jwdzj	91	13	evolution	evolution	NN
cord-277417-f71jwdzj	91	14	of	of	IN
cord-277417-f71jwdzj	91	15	key	key	JJ
cord-277417-f71jwdzj	91	16	phenotypic	phenotypic	JJ
cord-277417-f71jwdzj	91	17	traits	trait	NNS
cord-277417-f71jwdzj	91	18	such	such	JJ
cord-277417-f71jwdzj	91	19	as	as	IN
cord-277417-f71jwdzj	91	20	virulence	virulence	NN
cord-277417-f71jwdzj	91	21	9	9	CD
cord-277417-f71jwdzj	91	22	(	(	-LRB-
cord-277417-f71jwdzj	91	23	and	and	CC
cord-277417-f71jwdzj	91	24	see	see	VB
cord-277417-f71jwdzj	91	25	the	the	DT
cord-277417-f71jwdzj	91	26	examples	example	NNS
cord-277417-f71jwdzj	91	27	described	describe	VBN
cord-277417-f71jwdzj	91	28	below	below	RB
cord-277417-f71jwdzj	91	29	)	)	-RRB-
cord-277417-f71jwdzj	91	30	.	.	.
cord-277417-f71jwdzj	92	1	Phylogenomics	Phylogenomics	NNP
cord-277417-f71jwdzj	92	2	provides	provide	VBZ
cord-277417-f71jwdzj	92	3	an	an	DT
cord-277417-f71jwdzj	92	4	informative	informative	JJ
cord-277417-f71jwdzj	92	5	way	way	NN
cord-277417-f71jwdzj	92	6	to	to	TO
cord-277417-f71jwdzj	92	7	help	help	VB
cord-277417-f71jwdzj	92	8	understand	understand	VB
cord-277417-f71jwdzj	92	9	virulence	virulence	NN
cord-277417-f71jwdzj	92	10	evolution	evolution	NN
cord-277417-f71jwdzj	92	11	and	and	CC
cord-277417-f71jwdzj	92	12	establishes	establish	VBZ
cord-277417-f71jwdzj	92	13	a	a	DT
cord-277417-f71jwdzj	92	14	set	set	NN
cord-277417-f71jwdzj	92	15	of	of	IN
cord-277417-f71jwdzj	92	16	hypotheses	hypothesis	NNS
cord-277417-f71jwdzj	92	17	that	that	WDT
cord-277417-f71jwdzj	92	18	can	can	MD
cord-277417-f71jwdzj	92	19	be	be	VB
cord-277417-f71jwdzj	92	20	tested	test	VBN
cord-277417-f71jwdzj	92	21	using	use	VBG
cord-277417-f71jwdzj	92	22	appropriate	appropriate	JJ
cord-277417-f71jwdzj	92	23	experimental	experimental	JJ
cord-277417-f71jwdzj	92	24	assays	assay	NNS
cord-277417-f71jwdzj	92	25	8	8	CD
cord-277417-f71jwdzj	92	26	,	,	,
cord-277417-f71jwdzj	92	27	9	9	CD
cord-277417-f71jwdzj	92	28	.	.	.
cord-277417-f71jwdzj	93	1	We	-PRON-	PRP
cord-277417-f71jwdzj	93	2	also	also	RB
cord-277417-f71jwdzj	93	3	believe	believe	VBP
cord-277417-f71jwdzj	93	4	that	that	IN
cord-277417-f71jwdzj	93	5	phylogenomics	phylogenomic	NNS
cord-277417-f71jwdzj	93	6	provides	provide	VBZ
cord-277417-f71jwdzj	93	7	valuable	valuable	JJ
cord-277417-f71jwdzj	93	8	information	information	NN
cord-277417-f71jwdzj	93	9	on	on	IN
cord-277417-f71jwdzj	93	10	how	how	WRB
cord-277417-f71jwdzj	93	11	natural	natural	JJ
cord-277417-f71jwdzj	93	12	selection	selection	NN
cord-277417-f71jwdzj	93	13	acts	act	VBZ
cord-277417-f71jwdzj	93	14	on	on	IN
cord-277417-f71jwdzj	93	15	virulence	virulence	NN
cord-277417-f71jwdzj	93	16	and	and	CC
cord-277417-f71jwdzj	93	17	can	can	MD
cord-277417-f71jwdzj	93	18	be	be	VB
cord-277417-f71jwdzj	93	19	used	use	VBN
cord-277417-f71jwdzj	93	20	to	to	TO
cord-277417-f71jwdzj	93	21	test	test	VB
cord-277417-f71jwdzj	93	22	general	general	JJ
cord-277417-f71jwdzj	93	23	models	model	NNS
cord-277417-f71jwdzj	93	24	of	of	IN
cord-277417-f71jwdzj	93	25	virulence	virulence	NN
cord-277417-f71jwdzj	93	26	evolution	evolution	NN
cord-277417-f71jwdzj	93	27	,	,	,
cord-277417-f71jwdzj	93	28	thereby	thereby	RB
cord-277417-f71jwdzj	93	29	providing	provide	VBG
cord-277417-f71jwdzj	93	30	a	a	DT
cord-277417-f71jwdzj	93	31	key	key	JJ
cord-277417-f71jwdzj	93	32	link	link	NN
cord-277417-f71jwdzj	93	33	between	between	IN
cord-277417-f71jwdzj	93	34	theoretical	theoretical	JJ
cord-277417-f71jwdzj	93	35	and	and	CC
cord-277417-f71jwdzj	93	36	empirical	empirical	JJ
cord-277417-f71jwdzj	93	37	approaches	approach	NNS
cord-277417-f71jwdzj	93	38	to	to	IN
cord-277417-f71jwdzj	93	39	studying	study	VBG
cord-277417-f71jwdzj	93	40	virulence	virulence	NN
cord-277417-f71jwdzj	93	41	evolution	evolution	NN
cord-277417-f71jwdzj	93	42	.	.	.
cord-277417-f71jwdzj	94	1	The	the	DT
cord-277417-f71jwdzj	94	2	crux	crux	NN
cord-277417-f71jwdzj	94	3	of	of	IN
cord-277417-f71jwdzj	94	4	this	this	DT
cord-277417-f71jwdzj	94	5	approach	approach	NN
cord-277417-f71jwdzj	94	6	involves	involve	VBZ
cord-277417-f71jwdzj	94	7	mapping	mapping	NN
cord-277417-f71jwdzj	94	8	mutations	mutation	NNS
cord-277417-f71jwdzj	94	9	 	 	_SP
cord-277417-f71jwdzj	95	1	There	there	EX
cord-277417-f71jwdzj	95	2	is	be	VBZ
cord-277417-f71jwdzj	95	3	no	no	DT
cord-277417-f71jwdzj	95	4	clear	clear	JJ
cord-277417-f71jwdzj	95	5	understanding	understanding	NN
cord-277417-f71jwdzj	95	6	on	on	IN
cord-277417-f71jwdzj	95	7	whether	whether	IN
cord-277417-f71jwdzj	95	8	emerging	emerge	VBG
cord-277417-f71jwdzj	95	9	viruses	virus	NNS
cord-277417-f71jwdzj	95	10	become	become	VBP
cord-277417-f71jwdzj	95	11	more	more	RBR
cord-277417-f71jwdzj	95	12	or	or	CC
cord-277417-f71jwdzj	95	13	less	less	RBR
cord-277417-f71jwdzj	95	14	virulent	virulent	JJ
cord-277417-f71jwdzj	95	15	following	follow	VBG
cord-277417-f71jwdzj	95	16	a	a	DT
cord-277417-f71jwdzj	95	17	jump	jump	NN
cord-277417-f71jwdzj	95	18	to	to	IN
cord-277417-f71jwdzj	95	19	a	a	DT
cord-277417-f71jwdzj	95	20	new	new	JJ
cord-277417-f71jwdzj	95	21	host	host	NN
cord-277417-f71jwdzj	95	22	.	.	.
cord-277417-f71jwdzj	96	1	Before	before	IN
cord-277417-f71jwdzj	96	2	a	a	DT
cord-277417-f71jwdzj	96	3	host	host	NN
cord-277417-f71jwdzj	96	4	jump	jump	NN
cord-277417-f71jwdzj	96	5	,	,	,
cord-277417-f71jwdzj	96	6	pathogens	pathogen	NNS
cord-277417-f71jwdzj	96	7	are	be	VBP
cord-277417-f71jwdzj	96	8	likely	likely	JJ
cord-277417-f71jwdzj	96	9	to	to	TO
cord-277417-f71jwdzj	96	10	have	have	VB
cord-277417-f71jwdzj	96	11	been	be	VBN
cord-277417-f71jwdzj	96	12	selected	select	VBN
cord-277417-f71jwdzj	96	13	to	to	TO
cord-277417-f71jwdzj	96	14	optimize	optimize	VB
cord-277417-f71jwdzj	96	15	their	-PRON-	PRP$
cord-277417-f71jwdzj	96	16	virulence	virulence	NN
cord-277417-f71jwdzj	96	17	for	for	IN
cord-277417-f71jwdzj	96	18	onward	onward	JJ
cord-277417-f71jwdzj	96	19	transmission	transmission	NN
cord-277417-f71jwdzj	96	20	in	in	IN
cord-277417-f71jwdzj	96	21	the	the	DT
cord-277417-f71jwdzj	96	22	reservoir	reservoir	NN
cord-277417-f71jwdzj	96	23	host	host	NN
cord-277417-f71jwdzj	96	24	.	.	.
cord-277417-f71jwdzj	97	1	However	however	RB
cord-277417-f71jwdzj	97	2	,	,	,
cord-277417-f71jwdzj	97	3	immediately	immediately	RB
cord-277417-f71jwdzj	97	4	following	follow	VBG
cord-277417-f71jwdzj	97	5	a	a	DT
cord-277417-f71jwdzj	97	6	host	host	NN
cord-277417-f71jwdzj	97	7	jump	jump	NN
cord-277417-f71jwdzj	97	8	,	,	,
cord-277417-f71jwdzj	97	9	the	the	DT
cord-277417-f71jwdzj	97	10	pathogen	pathogen	NN
cord-277417-f71jwdzj	97	11	is	be	VBZ
cord-277417-f71jwdzj	97	12	likely	likely	JJ
cord-277417-f71jwdzj	97	13	to	to	TO
cord-277417-f71jwdzj	97	14	be	be	VB
cord-277417-f71jwdzj	97	15	initially	initially	RB
cord-277417-f71jwdzj	97	16	poorly	poorly	RB
cord-277417-f71jwdzj	97	17	adapted	adapt	VBN
cord-277417-f71jwdzj	97	18	to	to	IN
cord-277417-f71jwdzj	97	19	the	the	DT
cord-277417-f71jwdzj	97	20	new	new	JJ
cord-277417-f71jwdzj	97	21	host	host	NN
cord-277417-f71jwdzj	97	22	,	,	,
cord-277417-f71jwdzj	97	23	which	which	WDT
cord-277417-f71jwdzj	97	24	may	may	MD
cord-277417-f71jwdzj	97	25	inhibit	inhibit	VB
cord-277417-f71jwdzj	97	26	successful	successful	JJ
cord-277417-f71jwdzj	97	27	emergence	emergence	NN
cord-277417-f71jwdzj	97	28	135	135	CD
cord-277417-f71jwdzj	97	29	,	,	,
cord-277417-f71jwdzj	97	30	and	and	CC
cord-277417-f71jwdzj	97	31	the	the	DT
cord-277417-f71jwdzj	97	32	host	host	NN
cord-277417-f71jwdzj	97	33	is	be	VBZ
cord-277417-f71jwdzj	97	34	likely	likely	JJ
cord-277417-f71jwdzj	97	35	to	to	TO
cord-277417-f71jwdzj	97	36	be	be	VB
cord-277417-f71jwdzj	97	37	poorly	poorly	RB
cord-277417-f71jwdzj	97	38	adapted	adapt	VBN
cord-277417-f71jwdzj	97	39	to	to	IN
cord-277417-f71jwdzj	97	40	the	the	DT
cord-277417-f71jwdzj	97	41	new	new	JJ
cord-277417-f71jwdzj	97	42	pathogen	pathogen	NN
cord-277417-f71jwdzj	97	43	25	25	CD
cord-277417-f71jwdzj	97	44	.	.	.
cord-277417-f71jwdzj	98	1	Indeed	indeed	RB
cord-277417-f71jwdzj	98	2	,	,	,
cord-277417-f71jwdzj	98	3	high	high	JJ
cord-277417-f71jwdzj	98	4	host	host	NN
cord-277417-f71jwdzj	98	5	mortality	mortality	NN
cord-277417-f71jwdzj	98	6	is	be	VBZ
cord-277417-f71jwdzj	98	7	associated	associate	VBN
cord-277417-f71jwdzj	98	8	with	with	IN
cord-277417-f71jwdzj	98	9	a	a	DT
cord-277417-f71jwdzj	98	10	reduced	reduce	VBN
cord-277417-f71jwdzj	98	11	likelihood	likelihood	NN
cord-277417-f71jwdzj	98	12	of	of	IN
cord-277417-f71jwdzj	98	13	successful	successful	JJ
cord-277417-f71jwdzj	98	14	onward	onward	JJ
cord-277417-f71jwdzj	98	15	transmission	transmission	NN
cord-277417-f71jwdzj	98	16	in	in	IN
cord-277417-f71jwdzj	98	17	the	the	DT
cord-277417-f71jwdzj	98	18	case	case	NN
cord-277417-f71jwdzj	98	19	of	of	IN
cord-277417-f71jwdzj	98	20	human	human	JJ
cord-277417-f71jwdzj	98	21	viruses	virus	NNS
cord-277417-f71jwdzj	98	22	31	31	CD
cord-277417-f71jwdzj	98	23	.	.	.
cord-277417-f71jwdzj	99	1	There	there	EX
cord-277417-f71jwdzj	99	2	are	be	VBP
cord-277417-f71jwdzj	99	3	three	three	CD
cord-277417-f71jwdzj	99	4	possible	possible	JJ
cord-277417-f71jwdzj	99	5	scenarios	scenario	NNS
cord-277417-f71jwdzj	99	6	for	for	IN
cord-277417-f71jwdzj	99	7	virulence	virulence	NN
cord-277417-f71jwdzj	99	8	evolution	evolution	NN
cord-277417-f71jwdzj	99	9	immediately	immediately	RB
cord-277417-f71jwdzj	99	10	following	follow	VBG
cord-277417-f71jwdzj	99	11	a	a	DT
cord-277417-f71jwdzj	99	12	host	host	NN
cord-277417-f71jwdzj	99	13	jump	jump	NN
cord-277417-f71jwdzj	99	14	(	(	-LRB-
cord-277417-f71jwdzj	99	15	the	the	DT
cord-277417-f71jwdzj	99	16	filled	fill	VBN
cord-277417-f71jwdzj	99	17	nodes	node	NNS
cord-277417-f71jwdzj	99	18	in	in	IN
cord-277417-f71jwdzj	99	19	the	the	DT
cord-277417-f71jwdzj	99	20	figure	figure	NN
cord-277417-f71jwdzj	99	21	)	)	-RRB-
cord-277417-f71jwdzj	99	22	:	:	:
cord-277417-f71jwdzj	100	1	•	•	NNP
cord-277417-f71jwdzj	101	1	Some	some	DT
cord-277417-f71jwdzj	101	2	of	of	IN
cord-277417-f71jwdzj	101	3	the	the	DT
cord-277417-f71jwdzj	101	4	most	most	RBS
cord-277417-f71jwdzj	101	5	devastating	devastating	JJ
cord-277417-f71jwdzj	101	6	epidemics	epidemic	NNS
cord-277417-f71jwdzj	101	7	have	have	VBP
cord-277417-f71jwdzj	101	8	been	be	VBN
cord-277417-f71jwdzj	101	9	associated	associate	VBN
cord-277417-f71jwdzj	101	10	with	with	IN
cord-277417-f71jwdzj	101	11	an	an	DT
cord-277417-f71jwdzj	101	12	increase	increase	NN
cord-277417-f71jwdzj	101	13	in	in	IN
cord-277417-f71jwdzj	101	14	virulence	virulence	NN
cord-277417-f71jwdzj	101	15	following	follow	VBG
cord-277417-f71jwdzj	101	16	a	a	DT
cord-277417-f71jwdzj	101	17	cross	cross	JJ
cord-277417-f71jwdzj	101	18	-	-	JJ
cord-277417-f71jwdzj	101	19	species	species	JJ
cord-277417-f71jwdzj	101	20	transmission	transmission	NN
cord-277417-f71jwdzj	101	21	event	event	NN
cord-277417-f71jwdzj	101	22	(	(	-LRB-
cord-277417-f71jwdzj	101	23	see	see	VB
cord-277417-f71jwdzj	101	24	the	the	DT
cord-277417-f71jwdzj	101	25	figure	figure	NN
cord-277417-f71jwdzj	101	26	,	,	,
cord-277417-f71jwdzj	101	27	part	part	VB
cord-277417-f71jwdzj	101	28	a	a	DT
cord-277417-f71jwdzj	101	29	)	)	-RRB-
cord-277417-f71jwdzj	101	30	.	.	.
cord-277417-f71jwdzj	102	1	For	for	IN
cord-277417-f71jwdzj	102	2	example	example	NN
cord-277417-f71jwdzj	102	3	,	,	,
cord-277417-f71jwdzj	102	4	whereas	whereas	IN
cord-277417-f71jwdzj	102	5	HIv	HIv	NNP
cord-277417-f71jwdzj	102	6	almost	almost	RB
cord-277417-f71jwdzj	102	7	invariably	invariably	RB
cord-277417-f71jwdzj	102	8	progresses	progress	VBZ
cord-277417-f71jwdzj	102	9	to	to	IN
cord-277417-f71jwdzj	102	10	AIDS	AIDS	NNP
cord-277417-f71jwdzj	102	11	if	if	IN
cord-277417-f71jwdzj	102	12	untreated	untreated	JJ
cord-277417-f71jwdzj	102	13	in	in	IN
cord-277417-f71jwdzj	102	14	humans	human	NNS
cord-277417-f71jwdzj	102	15	,	,	,
cord-277417-f71jwdzj	102	16	in	in	IN
cord-277417-f71jwdzj	102	17	African	african	JJ
cord-277417-f71jwdzj	102	18	non	non	JJ
cord-277417-f71jwdzj	102	19	-	-	JJ
cord-277417-f71jwdzj	102	20	human	human	JJ
cord-277417-f71jwdzj	102	21	primates	primate	NNS
cord-277417-f71jwdzj	102	22	,	,	,
cord-277417-f71jwdzj	102	23	the	the	DT
cord-277417-f71jwdzj	102	24	closely	closely	RB
cord-277417-f71jwdzj	102	25	related	related	JJ
cord-277417-f71jwdzj	102	26	simian	simian	JJ
cord-277417-f71jwdzj	102	27	immunodeficiency	immunodeficiency	NN
cord-277417-f71jwdzj	102	28	virus	virus	NN
cord-277417-f71jwdzj	102	29	(	(	-LRB-
cord-277417-f71jwdzj	102	30	SIv	SIv	NNS
cord-277417-f71jwdzj	102	31	)	)	-RRB-
cord-277417-f71jwdzj	102	32	persists	persist	VBZ
cord-277417-f71jwdzj	102	33	without	without	IN
cord-277417-f71jwdzj	102	34	causing	cause	VBG
cord-277417-f71jwdzj	102	35	disease	disease	NN
cord-277417-f71jwdzj	102	36	136	136	CD
cord-277417-f71jwdzj	102	37	,	,	,
cord-277417-f71jwdzj	102	38	137	137	CD
cord-277417-f71jwdzj	102	39	or	or	CC
cord-277417-f71jwdzj	102	40	is	be	VBZ
cord-277417-f71jwdzj	102	41	associated	associate	VBN
cord-277417-f71jwdzj	102	42	with	with	IN
cord-277417-f71jwdzj	102	43	less	less	JJR
cord-277417-f71jwdzj	102	44	overt	overt	JJ
cord-277417-f71jwdzj	102	45	disease	disease	NN
cord-277417-f71jwdzj	102	46	than	than	IN
cord-277417-f71jwdzj	102	47	in	in	IN
cord-277417-f71jwdzj	102	48	humans	human	NNS
cord-277417-f71jwdzj	102	49	138	138	CD
cord-277417-f71jwdzj	102	50	.	.	.
cord-277417-f71jwdzj	103	1	Similarly	similarly	RB
cord-277417-f71jwdzj	103	2	,	,	,
cord-277417-f71jwdzj	103	3	the	the	DT
cord-277417-f71jwdzj	103	4	(	(	-LRB-
cord-277417-f71jwdzj	103	5	deliberate	deliberate	JJ
cord-277417-f71jwdzj	103	6	)	)	-RRB-
cord-277417-f71jwdzj	103	7	transfer	transfer	NN
cord-277417-f71jwdzj	103	8	of	of	IN
cord-277417-f71jwdzj	103	9	myxoma	myxoma	NN
cord-277417-f71jwdzj	103	10	virus	virus	NN
cord-277417-f71jwdzj	103	11	(	(	-LRB-
cord-277417-f71jwdzj	103	12	MYXv	MYXv	NNS
cord-277417-f71jwdzj	103	13	)	)	-RRB-
cord-277417-f71jwdzj	103	14	from	from	IN
cord-277417-f71jwdzj	103	15	the	the	DT
cord-277417-f71jwdzj	103	16	South	south	JJ
cord-277417-f71jwdzj	103	17	American	american	JJ
cord-277417-f71jwdzj	103	18	tapeti	tapeti	NN
cord-277417-f71jwdzj	103	19	,	,	,
cord-277417-f71jwdzj	103	20	where	where	WRB
cord-277417-f71jwdzj	103	21	it	-PRON-	PRP
cord-277417-f71jwdzj	103	22	was	be	VBD
cord-277417-f71jwdzj	103	23	largely	largely	RB
cord-277417-f71jwdzj	103	24	benign	benign	JJ
cord-277417-f71jwdzj	103	25	,	,	,
cord-277417-f71jwdzj	103	26	initially	initially	RB
cord-277417-f71jwdzj	103	27	resulted	result	VBD
cord-277417-f71jwdzj	103	28	in	in	IN
cord-277417-f71jwdzj	103	29	mortality	mortality	NN
cord-277417-f71jwdzj	103	30	of	of	IN
cord-277417-f71jwdzj	103	31	~99	~99	CD
cord-277417-f71jwdzj	103	32	%	%	NN
cord-277417-f71jwdzj	103	33	in	in	IN
cord-277417-f71jwdzj	103	34	European	european	JJ
cord-277417-f71jwdzj	103	35	rabbits	rabbit	NNS
cord-277417-f71jwdzj	103	36	11	11	CD
cord-277417-f71jwdzj	103	37	.	.	.
cord-277417-f71jwdzj	104	1	•	•	NNP
cord-277417-f71jwdzj	105	1	No	no	DT
cord-277417-f71jwdzj	105	2	apparent	apparent	JJ
cord-277417-f71jwdzj	105	3	change	change	NN
cord-277417-f71jwdzj	105	4	in	in	IN
cord-277417-f71jwdzj	105	5	virulence	virulence	NN
cord-277417-f71jwdzj	105	6	following	follow	VBG
cord-277417-f71jwdzj	105	7	a	a	DT
cord-277417-f71jwdzj	105	8	host	host	NN
cord-277417-f71jwdzj	105	9	jump	jump	NN
cord-277417-f71jwdzj	105	10	can	can	MD
cord-277417-f71jwdzj	105	11	be	be	VB
cord-277417-f71jwdzj	105	12	seen	see	VBN
cord-277417-f71jwdzj	105	13	in	in	IN
cord-277417-f71jwdzj	105	14	H3N8	H3N8	NNP
cord-277417-f71jwdzj	105	15	influenza	influenza	NN
cord-277417-f71jwdzj	105	16	A	a	DT
cord-277417-f71jwdzj	105	17	virus	virus	NN
cord-277417-f71jwdzj	105	18	that	that	WDT
cord-277417-f71jwdzj	105	19	jumped	jump	VBD
cord-277417-f71jwdzj	105	20	from	from	IN
cord-277417-f71jwdzj	105	21	horses	horse	NNS
cord-277417-f71jwdzj	105	22	to	to	IN
cord-277417-f71jwdzj	105	23	dogs	dog	NNS
cord-277417-f71jwdzj	105	24	139	139	CD
cord-277417-f71jwdzj	105	25	,	,	,
cord-277417-f71jwdzj	105	26	140	140	CD
cord-277417-f71jwdzj	105	27	(	(	-LRB-
cord-277417-f71jwdzj	105	28	see	see	VB
cord-277417-f71jwdzj	105	29	the	the	DT
cord-277417-f71jwdzj	105	30	figure	figure	NN
cord-277417-f71jwdzj	105	31	,	,	,
cord-277417-f71jwdzj	105	32	part	part	NN
cord-277417-f71jwdzj	105	33	b	b	NN
cord-277417-f71jwdzj	105	34	)	)	-RRB-
cord-277417-f71jwdzj	105	35	.	.	.
cord-277417-f71jwdzj	106	1	Disease	Disease	NNP
cord-277417-f71jwdzj	106	2	is	be	VBZ
cord-277417-f71jwdzj	106	3	mild	mild	JJ
cord-277417-f71jwdzj	106	4	in	in	IN
cord-277417-f71jwdzj	106	5	both	both	DT
cord-277417-f71jwdzj	106	6	cases	case	NNS
cord-277417-f71jwdzj	106	7	,	,	,
cord-277417-f71jwdzj	106	8	and	and	CC
cord-277417-f71jwdzj	106	9	there	there	EX
cord-277417-f71jwdzj	106	10	are	be	VBP
cord-277417-f71jwdzj	106	11	minimal	minimal	JJ
cord-277417-f71jwdzj	106	12	biological	biological	JJ
cord-277417-f71jwdzj	106	13	differences	difference	NNS
cord-277417-f71jwdzj	106	14	between	between	IN
cord-277417-f71jwdzj	106	15	these	these	DT
cord-277417-f71jwdzj	106	16	viruses	virus	NNS
cord-277417-f71jwdzj	106	17	141	141	CD
cord-277417-f71jwdzj	106	18	.	.	.
cord-277417-f71jwdzj	107	1	Similarly	similarly	RB
cord-277417-f71jwdzj	107	2	,	,	,
cord-277417-f71jwdzj	107	3	rabies	rabies	NN
cord-277417-f71jwdzj	107	4	virus	virus	NN
cord-277417-f71jwdzj	107	5	(	(	-LRB-
cord-277417-f71jwdzj	107	6	RABv	RABv	NNP
cord-277417-f71jwdzj	107	7	)	)	-RRB-
cord-277417-f71jwdzj	107	8	causes	cause	VBZ
cord-277417-f71jwdzj	107	9	an	an	DT
cord-277417-f71jwdzj	107	10	equally	equally	RB
cord-277417-f71jwdzj	107	11	severe	severe	JJ
cord-277417-f71jwdzj	107	12	,	,	,
cord-277417-f71jwdzj	107	13	ultimately	ultimately	RB
cord-277417-f71jwdzj	107	14	fatal	fatal	JJ
cord-277417-f71jwdzj	107	15	encephalitis	encephalitis	RB
cord-277417-f71jwdzj	107	16	in	in	IN
cord-277417-f71jwdzj	107	17	foxes	fox	NNS
cord-277417-f71jwdzj	107	18	and	and	CC
cord-277417-f71jwdzj	107	19	dogs	dog	NNS
cord-277417-f71jwdzj	107	20	and	and	CC
cord-277417-f71jwdzj	107	21	following	follow	VBG
cord-277417-f71jwdzj	107	22	spillover	spillover	NN
cord-277417-f71jwdzj	107	23	to	to	IN
cord-277417-f71jwdzj	107	24	humans	human	NNS
cord-277417-f71jwdzj	107	25	142	142	CD
cord-277417-f71jwdzj	107	26	.	.	.
cord-277417-f71jwdzj	108	1	•	•	NNP
cord-277417-f71jwdzj	109	1	Cases	case	NNS
cord-277417-f71jwdzj	109	2	of	of	IN
cord-277417-f71jwdzj	109	3	decreased	decrease	VBN
cord-277417-f71jwdzj	109	4	virulence	virulence	NN
cord-277417-f71jwdzj	109	5	may	may	MD
cord-277417-f71jwdzj	109	6	be	be	VB
cord-277417-f71jwdzj	109	7	largely	largely	RB
cord-277417-f71jwdzj	109	8	overlooked	overlook	VBN
cord-277417-f71jwdzj	109	9	because	because	IN
cord-277417-f71jwdzj	109	10	avirulent	avirulent	NN
cord-277417-f71jwdzj	109	11	viruses	virus	NNS
cord-277417-f71jwdzj	109	12	will	will	MD
cord-277417-f71jwdzj	109	13	often	often	RB
cord-277417-f71jwdzj	109	14	persist	persist	VB
cord-277417-f71jwdzj	109	15	in	in	IN
cord-277417-f71jwdzj	109	16	a	a	DT
cord-277417-f71jwdzj	109	17	host	host	NN
cord-277417-f71jwdzj	109	18	population	population	NN
cord-277417-f71jwdzj	109	19	without	without	IN
cord-277417-f71jwdzj	109	20	detection	detection	NN
cord-277417-f71jwdzj	109	21	.	.	.
cord-277417-f71jwdzj	110	1	An	an	DT
cord-277417-f71jwdzj	110	2	example	example	NN
cord-277417-f71jwdzj	110	3	of	of	IN
cord-277417-f71jwdzj	110	4	decreased	decrease	VBN
cord-277417-f71jwdzj	110	5	virulence	virulence	NN
cord-277417-f71jwdzj	110	6	following	follow	VBG
cord-277417-f71jwdzj	110	7	a	a	DT
cord-277417-f71jwdzj	110	8	host	host	NN
cord-277417-f71jwdzj	110	9	jump	jump	NN
cord-277417-f71jwdzj	110	10	may	may	MD
cord-277417-f71jwdzj	110	11	be	be	VB
cord-277417-f71jwdzj	110	12	that	that	DT
cord-277417-f71jwdzj	110	13	of	of	IN
cord-277417-f71jwdzj	110	14	the	the	DT
cord-277417-f71jwdzj	110	15	infectious	infectious	JJ
cord-277417-f71jwdzj	110	16	haematopoietic	haematopoietic	JJ
cord-277417-f71jwdzj	110	17	necrosis	necrosis	NN
cord-277417-f71jwdzj	110	18	virus	virus	NN
cord-277417-f71jwdzj	110	19	(	(	-LRB-
cord-277417-f71jwdzj	110	20	IHNv	IHNv	NNP
cord-277417-f71jwdzj	110	21	)	)	-RRB-
cord-277417-f71jwdzj	110	22	that	that	WDT
cord-277417-f71jwdzj	110	23	spread	spread	VBD
cord-277417-f71jwdzj	110	24	from	from	IN
cord-277417-f71jwdzj	110	25	sockeye	sockeye	NN
cord-277417-f71jwdzj	110	26	salmon	salmon	NN
cord-277417-f71jwdzj	110	27	to	to	TO
cord-277417-f71jwdzj	110	28	rainbow	rainbow	NN
cord-277417-f71jwdzj	110	29	trout	trout	NNS
cord-277417-f71jwdzj	110	30	in	in	IN
cord-277417-f71jwdzj	110	31	North	North	NNP
cord-277417-f71jwdzj	110	32	America	America	NNP
cord-277417-f71jwdzj	110	33	and	and	CC
cord-277417-f71jwdzj	110	34	Japan	Japan	NNP
cord-277417-f71jwdzj	110	35	(	(	-LRB-
cord-277417-f71jwdzj	110	36	see	see	VB
cord-277417-f71jwdzj	110	37	the	the	DT
cord-277417-f71jwdzj	110	38	figure	figure	NN
cord-277417-f71jwdzj	110	39	,	,	,
cord-277417-f71jwdzj	110	40	part	part	NN
cord-277417-f71jwdzj	110	41	c	c	NN
cord-277417-f71jwdzj	110	42	)	)	-RRB-
cord-277417-f71jwdzj	110	43	.	.	.
cord-277417-f71jwdzj	111	1	upon	upon	IN
cord-277417-f71jwdzj	111	2	the	the	DT
cord-277417-f71jwdzj	111	3	initial	initial	JJ
cord-277417-f71jwdzj	111	4	cross	cross	JJ
cord-277417-f71jwdzj	111	5	-	-	JJ
cord-277417-f71jwdzj	111	6	species	species	JJ
cord-277417-f71jwdzj	111	7	transmission	transmission	NN
cord-277417-f71jwdzj	111	8	event	event	NN
cord-277417-f71jwdzj	111	9	in	in	IN
cord-277417-f71jwdzj	111	10	the	the	DT
cord-277417-f71jwdzj	111	11	1950s	1950	NNS
cord-277417-f71jwdzj	111	12	to	to	IN
cord-277417-f71jwdzj	111	13	1960s	1960s	CD
cord-277417-f71jwdzj	111	14	,	,	,
cord-277417-f71jwdzj	111	15	the	the	DT
cord-277417-f71jwdzj	111	16	virus	virus	NN
cord-277417-f71jwdzj	111	17	seemed	seem	VBD
cord-277417-f71jwdzj	111	18	at	at	IN
cord-277417-f71jwdzj	111	19	first	first	RB
cord-277417-f71jwdzj	111	20	to	to	TO
cord-277417-f71jwdzj	111	21	be	be	VB
cord-277417-f71jwdzj	111	22	avirulent	avirulent	JJ
cord-277417-f71jwdzj	111	23	in	in	IN
cord-277417-f71jwdzj	111	24	the	the	DT
cord-277417-f71jwdzj	111	25	new	new	JJ
cord-277417-f71jwdzj	111	26	host	host	NN
cord-277417-f71jwdzj	111	27	in	in	IN
cord-277417-f71jwdzj	111	28	contrast	contrast	NN
cord-277417-f71jwdzj	111	29	to	to	IN
cord-277417-f71jwdzj	111	30	the	the	DT
cord-277417-f71jwdzj	111	31	mortality	mortality	NN
cord-277417-f71jwdzj	111	32	seen	see	VBN
cord-277417-f71jwdzj	111	33	in	in	IN
cord-277417-f71jwdzj	111	34	sockeye	sockeye	NN
cord-277417-f71jwdzj	111	35	salmon	salmon	NN
cord-277417-f71jwdzj	111	36	.	.	.
cord-277417-f71jwdzj	112	1	Since	since	IN
cord-277417-f71jwdzj	112	2	then	then	RB
cord-277417-f71jwdzj	112	3	,	,	,
cord-277417-f71jwdzj	112	4	however	however	RB
cord-277417-f71jwdzj	112	5	,	,	,
cord-277417-f71jwdzj	112	6	virulence	virulence	NN
cord-277417-f71jwdzj	112	7	in	in	IN
cord-277417-f71jwdzj	112	8	some	some	DT
cord-277417-f71jwdzj	112	9	genotypes	genotype	NNS
cord-277417-f71jwdzj	112	10	of	of	IN
cord-277417-f71jwdzj	112	11	IHNv	IHNv	NNS
cord-277417-f71jwdzj	112	12	in	in	IN
cord-277417-f71jwdzj	112	13	rainbow	rainbow	NN
cord-277417-f71jwdzj	112	14	trout	trout	NNP
cord-277417-f71jwdzj	112	15	has	have	VBZ
cord-277417-f71jwdzj	112	16	increased	increase	VBN
cord-277417-f71jwdzj	112	17	,	,	,
cord-277417-f71jwdzj	112	18	itself	-PRON-	PRP
cord-277417-f71jwdzj	112	19	associated	associate	VBD
cord-277417-f71jwdzj	112	20	with	with	IN
cord-277417-f71jwdzj	112	21	an	an	DT
cord-277417-f71jwdzj	112	22	increase	increase	NN
cord-277417-f71jwdzj	112	23	in	in	IN
cord-277417-f71jwdzj	112	24	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	112	25	143	143	CD
cord-277417-f71jwdzj	112	26	,	,	,
cord-277417-f71jwdzj	112	27	144	144	CD
cord-277417-f71jwdzj	112	28	.	.	.
cord-277417-f71jwdzj	113	1	For	for	IN
cord-277417-f71jwdzj	113	2	many	many	JJ
cord-277417-f71jwdzj	113	3	diseases	disease	NNS
cord-277417-f71jwdzj	113	4	,	,	,
cord-277417-f71jwdzj	113	5	however	however	RB
cord-277417-f71jwdzj	113	6	,	,	,
cord-277417-f71jwdzj	113	7	the	the	DT
cord-277417-f71jwdzj	113	8	extent	extent	NN
cord-277417-f71jwdzj	113	9	of	of	IN
cord-277417-f71jwdzj	113	10	changes	change	NNS
cord-277417-f71jwdzj	113	11	in	in	IN
cord-277417-f71jwdzj	113	12	virulence	virulence	NN
cord-277417-f71jwdzj	113	13	upon	upon	IN
cord-277417-f71jwdzj	113	14	emergence	emergence	NN
cord-277417-f71jwdzj	113	15	is	be	VBZ
cord-277417-f71jwdzj	113	16	not	not	RB
cord-277417-f71jwdzj	113	17	known	know	VBN
cord-277417-f71jwdzj	113	18	,	,	,
cord-277417-f71jwdzj	113	19	in	in	IN
cord-277417-f71jwdzj	113	20	part	part	NN
cord-277417-f71jwdzj	113	21	because	because	IN
cord-277417-f71jwdzj	113	22	little	little	JJ
cord-277417-f71jwdzj	113	23	is	be	VBZ
cord-277417-f71jwdzj	113	24	usually	usually	RB
cord-277417-f71jwdzj	113	25	known	know	VBN
cord-277417-f71jwdzj	113	26	about	about	IN
cord-277417-f71jwdzj	113	27	disease	disease	NN
cord-277417-f71jwdzj	113	28	epidemiology	epidemiology	NN
cord-277417-f71jwdzj	113	29	in	in	IN
cord-277417-f71jwdzj	113	30	reservoir	reservoir	NN
cord-277417-f71jwdzj	113	31	hosts	host	NNS
cord-277417-f71jwdzj	113	32	,	,	,
cord-277417-f71jwdzj	113	33	and	and	CC
cord-277417-f71jwdzj	113	34	there	there	EX
cord-277417-f71jwdzj	113	35	is	be	VBZ
cord-277417-f71jwdzj	113	36	likely	likely	JJ
cord-277417-f71jwdzj	113	37	to	to	TO
cord-277417-f71jwdzj	113	38	be	be	VB
cord-277417-f71jwdzj	113	39	a	a	DT
cord-277417-f71jwdzj	113	40	sampling	sampling	NN
cord-277417-f71jwdzj	113	41	bias	bias	NN
cord-277417-f71jwdzj	113	42	towards	towards	IN
cord-277417-f71jwdzj	113	43	the	the	DT
cord-277417-f71jwdzj	113	44	cases	case	NNS
cord-277417-f71jwdzj	113	45	of	of	IN
cord-277417-f71jwdzj	113	46	highest	high	JJS
cord-277417-f71jwdzj	113	47	virulence	virulence	NN
cord-277417-f71jwdzj	113	48	.	.	.
cord-277417-f71jwdzj	114	1	NATuRE	NATuRE	NNP
cord-277417-f71jwdzj	115	1	REvIEwS	REvIEwS	NNP
cord-277417-f71jwdzj	115	2	|	|	NNP
cord-277417-f71jwdzj	116	1	GEnETiCs	genetics	NN
cord-277417-f71jwdzj	116	2	R	r	NN
cord-277417-f71jwdzj	116	3	e	e	NN
cord-277417-f71jwdzj	117	1	v	v	LS
cord-277417-f71jwdzj	118	1	i	i	PRP
cord-277417-f71jwdzj	119	1	e	e	NNP
cord-277417-f71jwdzj	119	2	w	w	NN
cord-277417-f71jwdzj	119	3	s	s	NNP
cord-277417-f71jwdzj	119	4	voluME	voluME	NNP
cord-277417-f71jwdzj	119	5	19	19	CD
cord-277417-f71jwdzj	119	6	|	|	NNP
cord-277417-f71jwdzj	119	7	DECEMBER	DECEMBER	NNP
cord-277417-f71jwdzj	119	8	2018	2018	CD
cord-277417-f71jwdzj	120	1	|	|	NNP
cord-277417-f71jwdzj	120	2	759	759	CD
cord-277417-f71jwdzj	121	1	The	the	DT
cord-277417-f71jwdzj	121	2	initial	initial	JJ
cord-277417-f71jwdzj	121	3	and	and	CC
cord-277417-f71jwdzj	121	4	sometimes	sometimes	RB
cord-277417-f71jwdzj	121	5	transient	transient	JJ
cord-277417-f71jwdzj	121	6	appearance	appearance	NN
cord-277417-f71jwdzj	121	7	of	of	IN
cord-277417-f71jwdzj	121	8	a	a	DT
cord-277417-f71jwdzj	121	9	pathogen	pathogen	NN
cord-277417-f71jwdzj	121	10	in	in	IN
cord-277417-f71jwdzj	121	11	a	a	DT
cord-277417-f71jwdzj	121	12	new	new	JJ
cord-277417-f71jwdzj	121	13	species	specie	NNS
cord-277417-f71jwdzj	121	14	following	follow	VBG
cord-277417-f71jwdzj	121	15	a	a	DT
cord-277417-f71jwdzj	121	16	host	host	NN
cord-277417-f71jwdzj	121	17	jump	jump	NN
cord-277417-f71jwdzj	121	18	.	.	.
cord-277417-f71jwdzj	122	1	onto	onto	IN
cord-277417-f71jwdzj	122	2	phylogenetic	phylogenetic	JJ
cord-277417-f71jwdzj	122	3	trees	tree	NNS
cord-277417-f71jwdzj	122	4	of	of	IN
cord-277417-f71jwdzj	122	5	viruses	virus	NNS
cord-277417-f71jwdzj	122	6	sampled	sample	VBN
cord-277417-f71jwdzj	122	7	within	within	IN
cord-277417-f71jwdzj	122	8	and/or	and/or	CC
cord-277417-f71jwdzj	122	9	between	between	IN
cord-277417-f71jwdzj	122	10	disease	disease	NN
cord-277417-f71jwdzj	122	11	outbreaks	outbreak	NNS
cord-277417-f71jwdzj	122	12	and	and	CC
cord-277417-f71jwdzj	122	13	from	from	IN
cord-277417-f71jwdzj	122	14	reservoir	reservoir	NN
cord-277417-f71jwdzj	122	15	and	and	CC
cord-277417-f71jwdzj	122	16	novel	novel	NN
cord-277417-f71jwdzj	122	17	hosts	host	NNS
cord-277417-f71jwdzj	122	18	.	.	.
cord-277417-f71jwdzj	123	1	The	the	DT
cord-277417-f71jwdzj	123	2	phylogenetic	phylogenetic	JJ
cord-277417-f71jwdzj	123	3	location	location	NN
cord-277417-f71jwdzj	123	4	of	of	IN
cord-277417-f71jwdzj	123	5	these	these	DT
cord-277417-f71jwdzj	123	6	changeswhether	changeswhether	NNP
cord-277417-f71jwdzj	123	7	they	-PRON-	PRP
cord-277417-f71jwdzj	123	8	fall	fall	VBP
cord-277417-f71jwdzj	123	9	on	on	IN
cord-277417-f71jwdzj	123	10	shallow	shallow	JJ
cord-277417-f71jwdzj	123	11	or	or	CC
cord-277417-f71jwdzj	123	12	deep	deep	JJ
cord-277417-f71jwdzj	123	13	nodes	node	NNS
cord-277417-f71jwdzj	123	14	(	(	-LRB-
cord-277417-f71jwdzj	123	15	branches	branch	NNS
cord-277417-f71jwdzj	123	16	)	)	-RRB-
cord-277417-f71jwdzj	124	1	and/or	and/or	CC
cord-277417-f71jwdzj	124	2	singularly	singularly	RB
cord-277417-f71jwdzj	124	3	or	or	CC
cord-277417-f71jwdzj	124	4	in	in	IN
cord-277417-f71jwdzj	124	5	parallel	parallel	JJ
cord-277417-f71jwdzj	124	6	-makes	-makes	.
cord-277417-f71jwdzj	125	1	it	-PRON-	PRP
cord-277417-f71jwdzj	125	2	possible	possible	JJ
cord-277417-f71jwdzj	125	3	to	to	TO
cord-277417-f71jwdzj	125	4	infer	infer	VB
cord-277417-f71jwdzj	125	5	,	,	,
cord-277417-f71jwdzj	125	6	at	at	IN
cord-277417-f71jwdzj	125	7	least	least	JJS
cord-277417-f71jwdzj	125	8	in	in	IN
cord-277417-f71jwdzj	125	9	broad	broad	JJ
cord-277417-f71jwdzj	125	10	terms	term	NNS
cord-277417-f71jwdzj	125	11	,	,	,
cord-277417-f71jwdzj	125	12	the	the	DT
cord-277417-f71jwdzj	125	13	selection	selection	NN
cord-277417-f71jwdzj	125	14	pressures	pressure	NNS
cord-277417-f71jwdzj	125	15	acting	act	VBG
cord-277417-f71jwdzj	125	16	on	on	IN
cord-277417-f71jwdzj	125	17	virulence	virulence	NN
cord-277417-f71jwdzj	125	18	mutations	mutation	NNS
cord-277417-f71jwdzj	125	19	and	and	CC
cord-277417-f71jwdzj	125	20	from	from	IN
cord-277417-f71jwdzj	125	21	this	this	DT
cord-277417-f71jwdzj	125	22	infer	infer	VB
cord-277417-f71jwdzj	125	23	important	important	JJ
cord-277417-f71jwdzj	125	24	aspects	aspect	NNS
cord-277417-f71jwdzj	125	25	of	of	IN
cord-277417-f71jwdzj	125	26	virulence	virulence	NN
cord-277417-f71jwdzj	125	27	evolution	evolution	NN
cord-277417-f71jwdzj	125	28	(	(	-LRB-
cord-277417-f71jwdzj	125	29	box	box	NN
cord-277417-f71jwdzj	125	30	1	1	CD
cord-277417-f71jwdzj	125	31	;	;	:
cord-277417-f71jwdzj	125	32	FIg	FIg	NNS
cord-277417-f71jwdzj	125	33	.	.	.
cord-277417-f71jwdzj	126	1	1	1	LS
cord-277417-f71jwdzj	127	1	Fig	Fig	NNP
cord-277417-f71jwdzj	127	2	.	.	.
cord-277417-f71jwdzj	128	1	1	1	LS
cord-277417-f71jwdzj	128	2	|	|	NNP
cord-277417-f71jwdzj	128	3	Phylogenomics	Phylogenomics	NNPS
cord-277417-f71jwdzj	128	4	of	of	IN
cord-277417-f71jwdzj	128	5	virulence	virulence	NN
cord-277417-f71jwdzj	128	6	evolution	evolution	NN
cord-277417-f71jwdzj	128	7	.	.	.
cord-277417-f71jwdzj	129	1	a	a	DT
cord-277417-f71jwdzj	129	2	|	|	NNP
cord-277417-f71jwdzj	129	3	A	a	DT
cord-277417-f71jwdzj	129	4	model	model	NN
cord-277417-f71jwdzj	129	5	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	129	6	with	with	IN
cord-277417-f71jwdzj	129	7	virulence	virulence	NN
cord-277417-f71jwdzj	129	8	determinants	determinant	NNS
cord-277417-f71jwdzj	129	9	mapped	map	VBN
cord-277417-f71jwdzj	129	10	to	to	IN
cord-277417-f71jwdzj	129	11	a	a	DT
cord-277417-f71jwdzj	129	12	fairly	fairly	RB
cord-277417-f71jwdzj	129	13	deep	deep	JJ
cord-277417-f71jwdzj	129	14	node	node	NN
cord-277417-f71jwdzj	129	15	suggesting	suggest	VBG
cord-277417-f71jwdzj	129	16	that	that	IN
cord-277417-f71jwdzj	129	17	higher	high	JJR
cord-277417-f71jwdzj	129	18	virulence	virulence	NN
cord-277417-f71jwdzj	129	19	has	have	VBZ
cord-277417-f71jwdzj	129	20	increased	increase	VBN
cord-277417-f71jwdzj	129	21	virus	virus	NN
cord-277417-f71jwdzj	129	22	fitness	fitness	NN
cord-277417-f71jwdzj	129	23	.	.	.
cord-277417-f71jwdzj	130	1	b	b	LS
cord-277417-f71jwdzj	130	2	|	|	NNP
cord-277417-f71jwdzj	130	3	A	a	DT
cord-277417-f71jwdzj	130	4	model	model	NN
cord-277417-f71jwdzj	130	5	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	130	6	with	with	IN
cord-277417-f71jwdzj	130	7	virulence	virulence	NN
cord-277417-f71jwdzj	130	8	traits	trait	NNS
cord-277417-f71jwdzj	130	9	mapped	map	VBN
cord-277417-f71jwdzj	130	10	to	to	IN
cord-277417-f71jwdzj	130	11	shallow	shallow	JJ
cord-277417-f71jwdzj	130	12	nodes	node	NNS
cord-277417-f71jwdzj	130	13	suggesting	suggest	VBG
cord-277417-f71jwdzj	130	14	that	that	IN
cord-277417-f71jwdzj	130	15	higher	high	JJR
cord-277417-f71jwdzj	130	16	virulence	virulence	NN
cord-277417-f71jwdzj	130	17	reduced	reduce	VBN
cord-277417-f71jwdzj	130	18	pathogen	pathogen	NN
cord-277417-f71jwdzj	130	19	fitness	fitness	NN
cord-277417-f71jwdzj	130	20	so	so	IN
cord-277417-f71jwdzj	130	21	that	that	IN
cord-277417-f71jwdzj	130	22	viruses	virus	NNS
cord-277417-f71jwdzj	130	23	with	with	IN
cord-277417-f71jwdzj	130	24	these	these	DT
cord-277417-f71jwdzj	130	25	mutations	mutation	NNS
cord-277417-f71jwdzj	130	26	are	be	VBP
cord-277417-f71jwdzj	130	27	purged	purge	VBN
cord-277417-f71jwdzj	130	28	from	from	IN
cord-277417-f71jwdzj	130	29	the	the	DT
cord-277417-f71jwdzj	130	30	population	population	NN
cord-277417-f71jwdzj	130	31	or	or	CC
cord-277417-f71jwdzj	130	32	require	require	VB
cord-277417-f71jwdzj	130	33	compensatory	compensatory	JJ
cord-277417-f71jwdzj	130	34	mutations	mutation	NNS
cord-277417-f71jwdzj	130	35	.	.	.
cord-277417-f71jwdzj	131	1	c	c	NNP
cord-277417-f71jwdzj	131	2	|	|	:
cord-277417-f71jwdzj	131	3	A	a	DT
cord-277417-f71jwdzj	131	4	model	model	NN
cord-277417-f71jwdzj	131	5	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	131	6	with	with	IN
cord-277417-f71jwdzj	131	7	a	a	DT
cord-277417-f71jwdzj	131	8	high	high	JJ
cord-277417-f71jwdzj	131	9	-	-	HYPH
cord-277417-f71jwdzj	131	10	virulence	virulence	NN
cord-277417-f71jwdzj	131	11	mutation	mutation	NN
cord-277417-f71jwdzj	131	12	arising	arise	VBG
cord-277417-f71jwdzj	131	13	multiple	multiple	JJ
cord-277417-f71jwdzj	131	14	times	time	NNS
cord-277417-f71jwdzj	131	15	independently	independently	RB
cord-277417-f71jwdzj	131	16	owing	owe	VBG
cord-277417-f71jwdzj	131	17	to	to	IN
cord-277417-f71jwdzj	131	18	parallel	parallel	JJ
cord-277417-f71jwdzj	131	19	or	or	CC
cord-277417-f71jwdzj	131	20	convergent	convergent	JJ
cord-277417-f71jwdzj	131	21	evolution	evolution	NN
cord-277417-f71jwdzj	131	22	.	.	.
cord-277417-f71jwdzj	132	1	The	the	DT
cord-277417-f71jwdzj	132	2	occurrence	occurrence	NN
cord-277417-f71jwdzj	132	3	of	of	IN
cord-277417-f71jwdzj	132	4	parallel	parallel	JJ
cord-277417-f71jwdzj	132	5	/	/	SYM
cord-277417-f71jwdzj	132	6	convergent	convergent	JJ
cord-277417-f71jwdzj	132	7	mutations	mutation	NNS
cord-277417-f71jwdzj	132	8	that	that	WDT
cord-277417-f71jwdzj	132	9	occur	occur	VBP
cord-277417-f71jwdzj	132	10	more	more	RBR
cord-277417-f71jwdzj	132	11	frequently	frequently	RB
cord-277417-f71jwdzj	132	12	than	than	IN
cord-277417-f71jwdzj	132	13	by	by	IN
cord-277417-f71jwdzj	132	14	chance	chance	NN
cord-277417-f71jwdzj	133	1	8	8	CD
cord-277417-f71jwdzj	133	2	is	be	VBZ
cord-277417-f71jwdzj	133	3	likely	likely	JJ
cord-277417-f71jwdzj	133	4	to	to	TO
cord-277417-f71jwdzj	133	5	reflect	reflect	VB
cord-277417-f71jwdzj	133	6	adaptive	adaptive	JJ
cord-277417-f71jwdzj	133	7	evolution	evolution	NN
cord-277417-f71jwdzj	133	8	(	(	-LRB-
cord-277417-f71jwdzj	133	9	FIg	FIg	NNS
cord-277417-f71jwdzj	133	10	.	.	.
cord-277417-f71jwdzj	134	1	2	2	LS
cord-277417-f71jwdzj	134	2	)	)	-RRB-
cord-277417-f71jwdzj	134	3	.	.	.
cord-277417-f71jwdzj	135	1	d	d	NNP
cord-277417-f71jwdzj	135	2	|	|	NNP
cord-277417-f71jwdzj	136	1	The	the	DT
cord-277417-f71jwdzj	136	2	relationship	relationship	NN
cord-277417-f71jwdzj	136	3	between	between	IN
cord-277417-f71jwdzj	136	4	virulence	virulence	NN
cord-277417-f71jwdzj	136	5	,	,	,
cord-277417-f71jwdzj	136	6	fitness	fitness	NN
cord-277417-f71jwdzj	136	7	and	and	CC
cord-277417-f71jwdzj	136	8	host	host	NN
cord-277417-f71jwdzj	136	9	jumps	jump	NNS
cord-277417-f71jwdzj	136	10	.	.	.
cord-277417-f71jwdzj	137	1	A	a	DT
cord-277417-f71jwdzj	137	2	virus	virus	NN
cord-277417-f71jwdzj	137	3	is	be	VBZ
cord-277417-f71jwdzj	137	4	assumed	assume	VBN
cord-277417-f71jwdzj	137	5	to	to	TO
cord-277417-f71jwdzj	137	6	be	be	VB
cord-277417-f71jwdzj	137	7	at	at	IN
cord-277417-f71jwdzj	137	8	a	a	DT
cord-277417-f71jwdzj	137	9	fitness	fitness	NN
cord-277417-f71jwdzj	137	10	peak	peak	NN
cord-277417-f71jwdzj	137	11	(	(	-LRB-
cord-277417-f71jwdzj	137	12	high	high	JJ
cord-277417-f71jwdzj	137	13	R	r	NN
cord-277417-f71jwdzj	137	14	0	0	CD
cord-277417-f71jwdzj	137	15	)	)	-RRB-
cord-277417-f71jwdzj	137	16	,	,	,
cord-277417-f71jwdzj	137	17	in	in	IN
cord-277417-f71jwdzj	137	18	this	this	DT
cord-277417-f71jwdzj	137	19	case	case	NN
cord-277417-f71jwdzj	137	20	high	high	JJ
cord-277417-f71jwdzj	137	21	virulence	virulence	NN
cord-277417-f71jwdzj	137	22	,	,	,
cord-277417-f71jwdzj	137	23	in	in	IN
cord-277417-f71jwdzj	137	24	the	the	DT
cord-277417-f71jwdzj	137	25	reservoir	reservoir	NN
cord-277417-f71jwdzj	137	26	host	host	NN
cord-277417-f71jwdzj	137	27	,	,	,
cord-277417-f71jwdzj	137	28	so	so	IN
cord-277417-f71jwdzj	137	29	that	that	IN
cord-277417-f71jwdzj	137	30	the	the	DT
cord-277417-f71jwdzj	137	31	mutations	mutation	NNS
cord-277417-f71jwdzj	137	32	determining	determine	VBG
cord-277417-f71jwdzj	137	33	both	both	CC
cord-277417-f71jwdzj	137	34	virulence	virulence	NN
cord-277417-f71jwdzj	137	35	and	and	CC
cord-277417-f71jwdzj	137	36	host	host	NN
cord-277417-f71jwdzj	137	37	range	range	NN
cord-277417-f71jwdzj	137	38	are	be	VBP
cord-277417-f71jwdzj	137	39	expected	expect	VBN
cord-277417-f71jwdzj	137	40	to	to	TO
cord-277417-f71jwdzj	137	41	be	be	VB
cord-277417-f71jwdzj	137	42	subject	subject	JJ
cord-277417-f71jwdzj	137	43	to	to	IN
cord-277417-f71jwdzj	137	44	strong	strong	JJ
cord-277417-f71jwdzj	137	45	purifying	purifying	NN
cord-277417-f71jwdzj	137	46	selection	selection	NN
cord-277417-f71jwdzj	137	47	(	(	-LRB-
cord-277417-f71jwdzj	137	48	for	for	IN
cord-277417-f71jwdzj	137	49	example	example	NN
cord-277417-f71jwdzj	137	50	,	,	,
cord-277417-f71jwdzj	137	51	a	a	DT
cord-277417-f71jwdzj	137	52	low	low	JJ
cord-277417-f71jwdzj	137	53	value	value	NN
cord-277417-f71jwdzj	137	54	of	of	IN
cord-277417-f71jwdzj	137	55	d	d	NN
cord-277417-f71jwdzj	137	56	N	N	NNP
cord-277417-f71jwdzj	137	57	/d	/d	NNP
cord-277417-f71jwdzj	137	58	S	S	NNP
cord-277417-f71jwdzj	137	59	)	)	-RRB-
cord-277417-f71jwdzj	137	60	.	.	.
cord-277417-f71jwdzj	138	1	As	as	IN
cord-277417-f71jwdzj	138	2	the	the	DT
cord-277417-f71jwdzj	138	3	virus	virus	NN
cord-277417-f71jwdzj	138	4	emerges	emerge	VBZ
cord-277417-f71jwdzj	138	5	in	in	IN
cord-277417-f71jwdzj	138	6	the	the	DT
cord-277417-f71jwdzj	138	7	new	new	JJ
cord-277417-f71jwdzj	138	8	recipient	recipient	NN
cord-277417-f71jwdzj	138	9	host	host	NN
cord-277417-f71jwdzj	138	10	,	,	,
cord-277417-f71jwdzj	138	11	it	-PRON-	PRP
cord-277417-f71jwdzj	138	12	will	will	MD
cord-277417-f71jwdzj	138	13	initially	initially	RB
cord-277417-f71jwdzj	138	14	be	be	VB
cord-277417-f71jwdzj	138	15	maladapted	maladapted	JJ
cord-277417-f71jwdzj	138	16	(	(	-LRB-
cord-277417-f71jwdzj	138	17	that	that	RB
cord-277417-f71jwdzj	138	18	is	is	RB
cord-277417-f71jwdzj	138	19	,	,	,
cord-277417-f71jwdzj	138	20	reside	reside	VB
cord-277417-f71jwdzj	138	21	in	in	IN
cord-277417-f71jwdzj	138	22	a	a	DT
cord-277417-f71jwdzj	138	23	fitness	fitness	NN
cord-277417-f71jwdzj	138	24	valley	valley	NN
cord-277417-f71jwdzj	138	25	)	)	-RRB-
cord-277417-f71jwdzj	138	26	and	and	CC
cord-277417-f71jwdzj	138	27	subject	subject	JJ
cord-277417-f71jwdzj	138	28	to	to	IN
cord-277417-f71jwdzj	138	29	genetic	genetic	JJ
cord-277417-f71jwdzj	138	30	drift	drift	NN
cord-277417-f71jwdzj	138	31	as	as	IN
cord-277417-f71jwdzj	138	32	the	the	DT
cord-277417-f71jwdzj	138	33	population	population	NN
cord-277417-f71jwdzj	138	34	is	be	VBZ
cord-277417-f71jwdzj	138	35	small	small	JJ
cord-277417-f71jwdzj	138	36	.	.	.
cord-277417-f71jwdzj	139	1	As	as	IN
cord-277417-f71jwdzj	139	2	it	-PRON-	PRP
cord-277417-f71jwdzj	139	3	adapts	adapt	VBZ
cord-277417-f71jwdzj	139	4	to	to	IN
cord-277417-f71jwdzj	139	5	the	the	DT
cord-277417-f71jwdzj	139	6	new	new	JJ
cord-277417-f71jwdzj	139	7	host	host	NN
cord-277417-f71jwdzj	139	8	,	,	,
cord-277417-f71jwdzj	139	9	virulence	virulence	NN
cord-277417-f71jwdzj	139	10	will	will	MD
cord-277417-f71jwdzj	139	11	be	be	VB
cord-277417-f71jwdzj	139	12	selectively	selectively	RB
cord-277417-f71jwdzj	139	13	optimized	optimize	VBN
cord-277417-f71jwdzj	139	14	(	(	-LRB-
cord-277417-f71jwdzj	139	15	in	in	IN
cord-277417-f71jwdzj	139	16	this	this	DT
cord-277417-f71jwdzj	139	17	case	case	NN
cord-277417-f71jwdzj	139	18	declining	decline	VBG
cord-277417-f71jwdzj	139	19	)	)	-RRB-
cord-277417-f71jwdzj	139	20	,	,	,
cord-277417-f71jwdzj	139	21	increasing	increase	VBG
cord-277417-f71jwdzj	139	22	R	r	NN
cord-277417-f71jwdzj	139	23	0	0	CD
cord-277417-f71jwdzj	139	24	and	and	CC
cord-277417-f71jwdzj	139	25	resulting	result	VBG
cord-277417-f71jwdzj	139	26	in	in	IN
cord-277417-f71jwdzj	139	27	positive	positive	JJ
cord-277417-f71jwdzj	139	28	selection	selection	NN
cord-277417-f71jwdzj	139	29	(	(	-LRB-
cord-277417-f71jwdzj	139	30	for	for	IN
cord-277417-f71jwdzj	139	31	example	example	NN
cord-277417-f71jwdzj	139	32	,	,	,
cord-277417-f71jwdzj	139	33	d	d	NNP
cord-277417-f71jwdzj	139	34	N	N	NNP
cord-277417-f71jwdzj	139	35	/d	/d	NNP
cord-277417-f71jwdzj	139	36	S	s	NN
cord-277417-f71jwdzj	139	37	>	>	XX
cord-277417-f71jwdzj	140	1	1	1	LS
cord-277417-f71jwdzj	140	2	,	,	,
cord-277417-f71jwdzj	140	3	although	although	IN
cord-277417-f71jwdzj	140	4	other	other	JJ
cord-277417-f71jwdzj	140	5	measures	measure	NNS
cord-277417-f71jwdzj	140	6	of	of	IN
cord-277417-f71jwdzj	140	7	selection	selection	NN
cord-277417-f71jwdzj	140	8	pressure	pressure	NN
cord-277417-f71jwdzj	140	9	are	be	VBP
cord-277417-f71jwdzj	140	10	available	available	JJ
cord-277417-f71jwdzj	140	11	)	)	-RRB-
cord-277417-f71jwdzj	140	12	.	.	.
cord-277417-f71jwdzj	141	1	Once	once	IN
cord-277417-f71jwdzj	141	2	the	the	DT
cord-277417-f71jwdzj	141	3	virus	virus	NN
cord-277417-f71jwdzj	141	4	becomes	become	VBZ
cord-277417-f71jwdzj	141	5	adapted	adapt	VBN
cord-277417-f71jwdzj	141	6	to	to	IN
cord-277417-f71jwdzj	141	7	the	the	DT
cord-277417-f71jwdzj	141	8	new	new	JJ
cord-277417-f71jwdzj	141	9	host	host	NN
cord-277417-f71jwdzj	141	10	,	,	,
cord-277417-f71jwdzj	141	11	the	the	DT
cord-277417-f71jwdzj	141	12	virulence	virulence	NN
cord-277417-f71jwdzj	141	13	determinants	determinant	NNS
cord-277417-f71jwdzj	141	14	are	be	VBP
cord-277417-f71jwdzj	141	15	again	again	RB
cord-277417-f71jwdzj	141	16	subject	subject	JJ
cord-277417-f71jwdzj	141	17	to	to	IN
cord-277417-f71jwdzj	141	18	purifying	purify	VBG
cord-277417-f71jwdzj	141	19	selection	selection	NN
cord-277417-f71jwdzj	141	20	.	.	.
cord-277417-f71jwdzj	142	1	The	the	DT
cord-277417-f71jwdzj	142	2	greater	great	JJR
cord-277417-f71jwdzj	142	3	the	the	DT
cord-277417-f71jwdzj	142	4	fitness	fitness	NN
cord-277417-f71jwdzj	142	5	of	of	IN
cord-277417-f71jwdzj	142	6	a	a	DT
cord-277417-f71jwdzj	142	7	virulence	virulence	NN
cord-277417-f71jwdzj	142	8	determinant	determinant	NN
cord-277417-f71jwdzj	142	9	,	,	,
cord-277417-f71jwdzj	142	10	the	the	DT
cord-277417-f71jwdzj	142	11	more	more	RBR
cord-277417-f71jwdzj	142	12	rapidly	rapidly	RB
cord-277417-f71jwdzj	142	13	it	-PRON-	PRP
cord-277417-f71jwdzj	142	14	will	will	MD
cord-277417-f71jwdzj	142	15	spread	spread	VB
cord-277417-f71jwdzj	142	16	through	through	IN
cord-277417-f71jwdzj	142	17	the	the	DT
cord-277417-f71jwdzj	142	18	virus	virus	NN
cord-277417-f71jwdzj	142	19	population	population	NN
cord-277417-f71jwdzj	142	20	and	and	CC
cord-277417-f71jwdzj	142	21	the	the	DT
cord-277417-f71jwdzj	142	22	deeper	deep	JJR
cord-277417-f71jwdzj	142	23	it	-PRON-	PRP
cord-277417-f71jwdzj	142	24	will	will	MD
cord-277417-f71jwdzj	142	25	fall	fall	VB
cord-277417-f71jwdzj	142	26	on	on	IN
cord-277417-f71jwdzj	142	27	a	a	DT
cord-277417-f71jwdzj	142	28	virus	virus	NN
cord-277417-f71jwdzj	142	29	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	142	30	(	(	-LRB-
cord-277417-f71jwdzj	142	31	that	that	RB
cord-277417-f71jwdzj	142	32	is	is	RB
cord-277417-f71jwdzj	142	33	,	,	,
cord-277417-f71jwdzj	142	34	closer	close	JJR
cord-277417-f71jwdzj	142	35	to	to	IN
cord-277417-f71jwdzj	142	36	the	the	DT
cord-277417-f71jwdzj	142	37	root	root	NN
cord-277417-f71jwdzj	142	38	of	of	IN
cord-277417-f71jwdzj	142	39	the	the	DT
cord-277417-f71jwdzj	142	40	tree	tree	NN
cord-277417-f71jwdzj	142	41	)	)	-RRB-
cord-277417-f71jwdzj	142	42	,	,	,
cord-277417-f71jwdzj	142	43	including	include	VBG
cord-277417-f71jwdzj	142	44	on	on	IN
cord-277417-f71jwdzj	142	45	the	the	DT
cord-277417-f71jwdzj	142	46	branch	branch	NN
cord-277417-f71jwdzj	142	47	linking	link	VBG
cord-277417-f71jwdzj	142	48	reservoir	reservoir	NN
cord-277417-f71jwdzj	142	49	and	and	CC
cord-277417-f71jwdzj	142	50	novel	novel	NN
cord-277417-f71jwdzj	142	51	hosts	host	NNS
cord-277417-f71jwdzj	142	52	.	.	.
cord-277417-f71jwdzj	143	1	Of	of	IN
cord-277417-f71jwdzj	143	2	particular	particular	JJ
cord-277417-f71jwdzj	143	3	importance	importance	NN
cord-277417-f71jwdzj	143	4	are	be	VBP
cord-277417-f71jwdzj	143	5	repeated	repeat	VBN
cord-277417-f71jwdzj	143	6	occurrences	occurrence	NNS
cord-277417-f71jwdzj	143	7	of	of	IN
cord-277417-f71jwdzj	143	8	the	the	DT
cord-277417-f71jwdzj	143	9	same	same	JJ
cord-277417-f71jwdzj	143	10	mutation	mutation	NN
cord-277417-f71jwdzj	143	11	falling	fall	VBG
cord-277417-f71jwdzj	143	12	on	on	IN
cord-277417-f71jwdzj	143	13	deep	deep	JJ
cord-277417-f71jwdzj	143	14	branches	branch	NNS
cord-277417-f71jwdzj	143	15	across	across	IN
cord-277417-f71jwdzj	143	16	multiple	multiple	JJ
cord-277417-f71jwdzj	143	17	outbreaks	outbreak	NNS
cord-277417-f71jwdzj	143	18	,	,	,
cord-277417-f71jwdzj	143	19	or	or	CC
cord-277417-f71jwdzj	143	20	multiple	multiple	JJ
cord-277417-f71jwdzj	143	21	cross	cross	JJ
cord-277417-f71jwdzj	143	22	-	-	JJ
cord-277417-f71jwdzj	143	23	species	species	JJ
cord-277417-f71jwdzj	143	24	transmission	transmission	NN
cord-277417-f71jwdzj	143	25	events	event	NNS
cord-277417-f71jwdzj	143	26	,	,	,
cord-277417-f71jwdzj	143	27	as	as	IN
cord-277417-f71jwdzj	143	28	both	both	DT
cord-277417-f71jwdzj	143	29	parallel	parallel	JJ
cord-277417-f71jwdzj	143	30	evolution	evolution	NN
cord-277417-f71jwdzj	143	31	and	and	CC
cord-277417-f71jwdzj	143	32	convergent	convergent	JJ
cord-277417-f71jwdzj	143	33	evolution	evolution	NN
cord-277417-f71jwdzj	143	34	can	can	MD
cord-277417-f71jwdzj	143	35	be	be	VB
cord-277417-f71jwdzj	143	36	signatures	signature	NNS
cord-277417-f71jwdzj	143	37	of	of	IN
cord-277417-f71jwdzj	143	38	adaptive	adaptive	JJ
cord-277417-f71jwdzj	143	39	evolution	evolution	NN
cord-277417-f71jwdzj	144	1	8,54	8,54	LS
cord-277417-f71jwdzj	144	2	-	-	SYM
cord-277417-f71jwdzj	144	3	57	57	CD
cord-277417-f71jwdzj	144	4	(	(	-LRB-
cord-277417-f71jwdzj	144	5	FIg	FIg	NNS
cord-277417-f71jwdzj	144	6	.	.	.
cord-277417-f71jwdzj	145	1	1	1	LS
cord-277417-f71jwdzj	145	2	)	)	-RRB-
cord-277417-f71jwdzj	145	3	.	.	.
cord-277417-f71jwdzj	146	1	For	for	IN
cord-277417-f71jwdzj	146	2	example	example	NN
cord-277417-f71jwdzj	146	3	,	,	,
cord-277417-f71jwdzj	146	4	in	in	IN
cord-277417-f71jwdzj	146	5	the	the	DT
cord-277417-f71jwdzj	146	6	case	case	NN
cord-277417-f71jwdzj	146	7	of	of	IN
cord-277417-f71jwdzj	146	8	West	West	NNP
cord-277417-f71jwdzj	146	9	Nile	Nile	NNP
cord-277417-f71jwdzj	146	10	virus	virus	NN
cord-277417-f71jwdzj	146	11	(	(	-LRB-
cord-277417-f71jwdzj	146	12	WNV	WNV	NNP
cord-277417-f71jwdzj	146	13	)	)	-RRB-
cord-277417-f71jwdzj	146	14	,	,	,
cord-277417-f71jwdzj	146	15	a	a	DT
cord-277417-f71jwdzj	146	16	single	single	JJ
cord-277417-f71jwdzj	146	17	mutation	mutation	NN
cord-277417-f71jwdzj	146	18	in	in	IN
cord-277417-f71jwdzj	146	19	the	the	DT
cord-277417-f71jwdzj	146	20	virus	virus	NN
cord-277417-f71jwdzj	146	21	helicase	helicase	NN
cord-277417-f71jwdzj	146	22	protein	protein	NN
cord-277417-f71jwdzj	146	23	repeatedly	repeatedly	RB
cord-277417-f71jwdzj	146	24	evolved	evolve	VBD
cord-277417-f71jwdzj	146	25	in	in	IN
cord-277417-f71jwdzj	146	26	high	high	JJ
cord-277417-f71jwdzj	146	27	-	-	HYPH
cord-277417-f71jwdzj	146	28	mortality	mortality	NN
cord-277417-f71jwdzj	146	29	outbreaks	outbreak	NNS
cord-277417-f71jwdzj	146	30	in	in	IN
cord-277417-f71jwdzj	146	31	birds	bird	NNS
cord-277417-f71jwdzj	146	32	,	,	,
cord-277417-f71jwdzj	146	33	which	which	WDT
cord-277417-f71jwdzj	146	34	is	be	VBZ
cord-277417-f71jwdzj	146	35	indicative	indicative	JJ
cord-277417-f71jwdzj	146	36	of	of	IN
cord-277417-f71jwdzj	146	37	a	a	DT
cord-277417-f71jwdzj	146	38	selective	selective	JJ
cord-277417-f71jwdzj	146	39	advantage	advantage	NN
cord-277417-f71jwdzj	146	40	58	58	CD
cord-277417-f71jwdzj	146	41	.	.	.
cord-277417-f71jwdzj	147	1	Similarly	similarly	RB
cord-277417-f71jwdzj	147	2	,	,	,
cord-277417-f71jwdzj	147	3	the	the	DT
cord-277417-f71jwdzj	147	4	reversion	reversion	NN
cord-277417-f71jwdzj	147	5	to	to	IN
cord-277417-f71jwdzj	147	6	virulence	virulence	NN
cord-277417-f71jwdzj	147	7	in	in	IN
cord-277417-f71jwdzj	147	8	oral	oral	JJ
cord-277417-f71jwdzj	147	9	polio	polio	NN
cord-277417-f71jwdzj	147	10	vaccine	vaccine	NN
cord-277417-f71jwdzj	147	11	(	(	-LRB-
cord-277417-f71jwdzj	147	12	OPV	OPV	NNP
cord-277417-f71jwdzj	147	13	)	)	-RRB-
cord-277417-f71jwdzj	147	14	strains	strain	NNS
cord-277417-f71jwdzj	147	15	of	of	IN
cord-277417-f71jwdzj	147	16	poliovirus	poliovirus	NN
cord-277417-f71jwdzj	147	17	has	have	VBZ
cord-277417-f71jwdzj	147	18	been	be	VBN
cord-277417-f71jwdzj	147	19	associated	associate	VBN
cord-277417-f71jwdzj	147	20	with	with	IN
cord-277417-f71jwdzj	147	21	extensive	extensive	JJ
cord-277417-f71jwdzj	147	22	parallel	parallel	JJ
cord-277417-f71jwdzj	147	23	evolution	evolution	NN
cord-277417-f71jwdzj	147	24	8	8	CD
cord-277417-f71jwdzj	147	25	,	,	,
cord-277417-f71jwdzj	147	26	and	and	CC
cord-277417-f71jwdzj	147	27	parallel	parallel	JJ
cord-277417-f71jwdzj	147	28	evolution	evolution	NN
cord-277417-f71jwdzj	147	29	was	be	VBD
cord-277417-f71jwdzj	147	30	also	also	RB
cord-277417-f71jwdzj	147	31	associated	associate	VBN
cord-277417-f71jwdzj	147	32	with	with	IN
cord-277417-f71jwdzj	147	33	hostspecific	hostspecific	NNP
cord-277417-f71jwdzj	147	34	adaptation	adaptation	NN
cord-277417-f71jwdzj	147	35	in	in	IN
cord-277417-f71jwdzj	147	36	experimental	experimental	JJ
cord-277417-f71jwdzj	147	37	studies	study	NNS
cord-277417-f71jwdzj	147	38	of	of	IN
cord-277417-f71jwdzj	147	39	crossspecies	crossspecie	NNS
cord-277417-f71jwdzj	147	40	transmission	transmission	NN
cord-277417-f71jwdzj	147	41	involving	involve	VBG
cord-277417-f71jwdzj	147	42	Drosophila	Drosophila	NNP
cord-277417-f71jwdzj	147	43	virus	virus	NN
cord-277417-f71jwdzj	147	44	C	c	NN
cord-277417-f71jwdzj	147	45	59	59	CD
cord-277417-f71jwdzj	147	46	.	.	.
cord-277417-f71jwdzj	148	1	Because	because	IN
cord-277417-f71jwdzj	148	2	adaptive	adaptive	JJ
cord-277417-f71jwdzj	148	3	evolution	evolution	NN
cord-277417-f71jwdzj	148	4	has	have	VBZ
cord-277417-f71jwdzj	148	5	been	be	VBN
cord-277417-f71jwdzj	148	6	at	at	IN
cord-277417-f71jwdzj	148	7	play	play	NN
cord-277417-f71jwdzj	148	8	,	,	,
cord-277417-f71jwdzj	148	9	phylo	phylo	JJ
cord-277417-f71jwdzj	148	10	genies	genie	NNS
cord-277417-f71jwdzj	148	11	of	of	IN
cord-277417-f71jwdzj	148	12	the	the	DT
cord-277417-f71jwdzj	148	13	sequence	sequence	NN
cord-277417-f71jwdzj	148	14	in	in	IN
cord-277417-f71jwdzj	148	15	question	question	NN
cord-277417-f71jwdzj	148	16	may	may	MD
cord-277417-f71jwdzj	148	17	have	have	VB
cord-277417-f71jwdzj	148	18	a	a	DT
cord-277417-f71jwdzj	148	19	characteristic	characteristic	JJ
cord-277417-f71jwdzj	148	20	shape	shape	NN
cord-277417-f71jwdzj	148	21	24	24	CD
cord-277417-f71jwdzj	148	22	,	,	,
cord-277417-f71jwdzj	148	23	and	and	CC
cord-277417-f71jwdzj	148	24	the	the	DT
cord-277417-f71jwdzj	148	25	sequences	sequence	NNS
cord-277417-f71jwdzj	148	26	associated	associate	VBN
cord-277417-f71jwdzj	148	27	with	with	IN
cord-277417-f71jwdzj	148	28	selected	select	VBN
cord-277417-f71jwdzj	148	29	branches	branch	NNS
cord-277417-f71jwdzj	148	30	may	may	MD
cord-277417-f71jwdzj	148	31	also	also	RB
cord-277417-f71jwdzj	148	32	contain	contain	VB
cord-277417-f71jwdzj	148	33	genomic	genomic	JJ
cord-277417-f71jwdzj	148	34	signatures	signature	NNS
cord-277417-f71jwdzj	148	35	indicative	indicative	JJ
cord-277417-f71jwdzj	148	36	of	of	IN
cord-277417-f71jwdzj	148	37	positive	positive	JJ
cord-277417-f71jwdzj	148	38	selection	selection	NN
cord-277417-f71jwdzj	148	39	,	,	,
cord-277417-f71jwdzj	148	40	such	such	JJ
cord-277417-f71jwdzj	148	41	as	as	IN
cord-277417-f71jwdzj	148	42	the	the	DT
cord-277417-f71jwdzj	148	43	rapid	rapid	JJ
cord-277417-f71jwdzj	148	44	fixation	fixation	NN
cord-277417-f71jwdzj	148	45	of	of	IN
cord-277417-f71jwdzj	148	46	amino	amino	JJ
cord-277417-f71jwdzj	148	47	acid	acid	NN
cord-277417-f71jwdzj	148	48	changes	change	NNS
cord-277417-f71jwdzj	148	49	or	or	CC
cord-277417-f71jwdzj	148	50	an	an	DT
cord-277417-f71jwdzj	148	51	increased	increase	VBN
cord-277417-f71jwdzj	148	52	rate	rate	NN
cord-277417-f71jwdzj	148	53	of	of	IN
cord-277417-f71jwdzj	148	54	nonsynonymous	nonsynonymous	JJ
cord-277417-f71jwdzj	148	55	to	to	TO
cord-277417-f71jwdzj	148	56	synonymous	synonymous	JJ
cord-277417-f71jwdzj	148	57	substitutions	substitution	NNS
cord-277417-f71jwdzj	148	58	per	per	IN
cord-277417-f71jwdzj	148	59	site	site	NN
cord-277417-f71jwdzj	148	60	(	(	-LRB-
cord-277417-f71jwdzj	148	61	ratio	ratio	NN
cord-277417-f71jwdzj	148	62	d	d	NNP
cord-277417-f71jwdzj	148	63	N	N	NNP
cord-277417-f71jwdzj	148	64	/d	/d	NNP
cord-277417-f71jwdzj	148	65	S	S	NNP
cord-277417-f71jwdzj	148	66	)	)	-RRB-
cord-277417-f71jwdzj	148	67	8	8	CD
cord-277417-f71jwdzj	148	68	,	,	,
cord-277417-f71jwdzj	148	69	60	60	CD
cord-277417-f71jwdzj	148	70	.	.	.
cord-277417-f71jwdzj	149	1	In	in	IN
cord-277417-f71jwdzj	149	2	the	the	DT
cord-277417-f71jwdzj	149	3	case	case	NN
cord-277417-f71jwdzj	149	4	of	of	IN
cord-277417-f71jwdzj	149	5	frequent	frequent	JJ
cord-277417-f71jwdzj	149	6	parallel	parallel	NN
cord-277417-f71jwdzj	149	7	or	or	CC
cord-277417-f71jwdzj	149	8	convergent	convergent	JJ
cord-277417-f71jwdzj	149	9	evolution	evolution	NN
cord-277417-f71jwdzj	149	10	for	for	IN
cord-277417-f71jwdzj	149	11	specific	specific	JJ
cord-277417-f71jwdzj	149	12	virulence	virulence	NN
cord-277417-f71jwdzj	149	13	mutations	mutation	NNS
cord-277417-f71jwdzj	149	14	,	,	,
cord-277417-f71jwdzj	149	15	it	-PRON-	PRP
cord-277417-f71jwdzj	149	16	is	be	VBZ
cord-277417-f71jwdzj	149	17	also	also	RB
cord-277417-f71jwdzj	149	18	possible	possible	JJ
cord-277417-f71jwdzj	149	19	that	that	IN
cord-277417-f71jwdzj	149	20	the	the	DT
cord-277417-f71jwdzj	149	21	amino	amino	NN
cord-277417-f71jwdzj	149	22	acid	acid	NN
cord-277417-f71jwdzj	149	23	sites	site	NNS
cord-277417-f71jwdzj	149	24	involved	involve	VBN
cord-277417-f71jwdzj	149	25	will	will	MD
cord-277417-f71jwdzj	149	26	have	have	VB
cord-277417-f71jwdzj	149	27	signatures	signature	NNS
cord-277417-f71jwdzj	149	28	of	of	IN
cord-277417-f71jwdzj	149	29	positive	positive	JJ
cord-277417-f71jwdzj	149	30	selection	selection	NN
cord-277417-f71jwdzj	149	31	,	,	,
cord-277417-f71jwdzj	149	32	such	such	JJ
cord-277417-f71jwdzj	149	33	as	as	IN
cord-277417-f71jwdzj	149	34	an	an	DT
cord-277417-f71jwdzj	149	35	elevated	elevated	JJ
cord-277417-f71jwdzj	149	36	d	d	NN
cord-277417-f71jwdzj	149	37	N	n	NN
cord-277417-f71jwdzj	149	38	/d	/d	NNP
cord-277417-f71jwdzj	149	39	S	S	NNP
cord-277417-f71jwdzj	149	40	(	(	-LRB-
cord-277417-f71jwdzj	149	41	as	as	IN
cord-277417-f71jwdzj	149	42	was	be	VBD
cord-277417-f71jwdzj	149	43	the	the	DT
cord-277417-f71jwdzj	149	44	case	case	NN
cord-277417-f71jwdzj	149	45	in	in	IN
cord-277417-f71jwdzj	149	46	WNV	WNV	NNP
cord-277417-f71jwdzj	149	47	;	;	:
cord-277417-f71jwdzj	149	48	see	see	VB
cord-277417-f71jwdzj	149	49	below	below	RB
cord-277417-f71jwdzj	149	50	)	)	-RRB-
cord-277417-f71jwdzj	149	51	.	.	.
cord-277417-f71jwdzj	150	1	Following	follow	VBG
cord-277417-f71jwdzj	150	2	the	the	DT
cord-277417-f71jwdzj	150	3	same	same	JJ
cord-277417-f71jwdzj	150	4	logic	logic	NN
cord-277417-f71jwdzj	150	5	,	,	,
cord-277417-f71jwdzj	150	6	mutations	mutation	NNS
cord-277417-f71jwdzj	150	7	that	that	WDT
cord-277417-f71jwdzj	150	8	fall	fall	VBP
cord-277417-f71jwdzj	150	9	on	on	IN
cord-277417-f71jwdzj	150	10	shallow	shallow	JJ
cord-277417-f71jwdzj	150	11	branches	branch	NNS
cord-277417-f71jwdzj	150	12	in	in	IN
cord-277417-f71jwdzj	150	13	virus	virus	NN
cord-277417-f71jwdzj	150	14	phylogenies	phylogeny	NNS
cord-277417-f71jwdzj	150	15	(	(	-LRB-
cord-277417-f71jwdzj	150	16	that	that	RB
cord-277417-f71jwdzj	150	17	is	is	RB
cord-277417-f71jwdzj	150	18	,	,	,
cord-277417-f71jwdzj	150	19	closer	close	JJR
cord-277417-f71jwdzj	150	20	to	to	IN
cord-277417-f71jwdzj	150	21	the	the	DT
cord-277417-f71jwdzj	150	22	tips	tip	NNS
cord-277417-f71jwdzj	150	23	)	)	-RRB-
cord-277417-f71jwdzj	150	24	are	be	VBP
cord-277417-f71jwdzj	150	25	present	present	JJ
cord-277417-f71jwdzj	150	26	in	in	IN
cord-277417-f71jwdzj	150	27	a	a	DT
cord-277417-f71jwdzj	150	28	smaller	small	JJR
cord-277417-f71jwdzj	150	29	proportion	proportion	NN
cord-277417-f71jwdzj	150	30	of	of	IN
cord-277417-f71jwdzj	150	31	the	the	DT
cord-277417-f71jwdzj	150	32	population	population	NN
cord-277417-f71jwdzj	150	33	and	and	CC
cord-277417-f71jwdzj	150	34	are	be	VBP
cord-277417-f71jwdzj	150	35	therefore	therefore	RB
cord-277417-f71jwdzj	150	36	more	more	RBR
cord-277417-f71jwdzj	150	37	likely	likely	JJ
cord-277417-f71jwdzj	150	38	to	to	TO
cord-277417-f71jwdzj	150	39	be	be	VB
cord-277417-f71jwdzj	150	40	of	of	IN
cord-277417-f71jwdzj	150	41	lower	low	JJR
cord-277417-f71jwdzj	150	42	fitness	fitness	NN
cord-277417-f71jwdzj	150	43	such	such	JJ
cord-277417-f71jwdzj	150	44	that	that	IN
cord-277417-f71jwdzj	150	45	they	-PRON-	PRP
cord-277417-f71jwdzj	150	46	may	may	MD
cord-277417-f71jwdzj	150	47	be	be	VB
cord-277417-f71jwdzj	150	48	removed	remove	VBN
cord-277417-f71jwdzj	150	49	by	by	IN
cord-277417-f71jwdzj	150	50	purifying	purify	VBG
cord-277417-f71jwdzj	150	51	selection	selection	NN
cord-277417-f71jwdzj	150	52	.	.	.
cord-277417-f71jwdzj	151	1	Hence	hence	RB
cord-277417-f71jwdzj	151	2	,	,	,
cord-277417-f71jwdzj	151	3	virulence	virulence	NN
cord-277417-f71jwdzj	151	4	-	-	HYPH
cord-277417-f71jwdzj	151	5	determining	determine	VBG
cord-277417-f71jwdzj	151	6	mutations	mutation	NNS
cord-277417-f71jwdzj	151	7	that	that	WDT
cord-277417-f71jwdzj	151	8	repeatedly	repeatedly	RB
cord-277417-f71jwdzj	151	9	fall	fall	VBP
cord-277417-f71jwdzj	151	10	on	on	IN
cord-277417-f71jwdzj	151	11	tip	tip	NN
cord-277417-f71jwdzj	151	12	branches	branch	NNS
cord-277417-f71jwdzj	151	13	alone	alone	RB
cord-277417-f71jwdzj	151	14	are	be	VBP
cord-277417-f71jwdzj	151	15	likely	likely	JJ
cord-277417-f71jwdzj	151	16	to	to	TO
cord-277417-f71jwdzj	151	17	inhibit	inhibit	VB
cord-277417-f71jwdzj	151	18	some	some	DT
cord-277417-f71jwdzj	151	19	other	other	JJ
cord-277417-f71jwdzj	151	20	aspect	aspect	NN
cord-277417-f71jwdzj	151	21	of	of	IN
cord-277417-f71jwdzj	151	22	pathogen	pathogen	NN
cord-277417-f71jwdzj	151	23	fitness	fitness	NN
cord-277417-f71jwdzj	151	24	,	,	,
cord-277417-f71jwdzj	151	25	thereby	thereby	RB
cord-277417-f71jwdzj	151	26	reducing	reduce	VBG
cord-277417-f71jwdzj	151	27	R	r	NN
cord-277417-f71jwdzj	151	28	0	0	CD
cord-277417-f71jwdzj	151	29	at	at	IN
cord-277417-f71jwdzj	151	30	the	the	DT
cord-277417-f71jwdzj	151	31	population	population	NN
cord-277417-f71jwdzj	151	32	scale	scale	NN
cord-277417-f71jwdzj	151	33	.	.	.
cord-277417-f71jwdzj	152	1	Although	although	IN
cord-277417-f71jwdzj	152	2	this	this	DT
cord-277417-f71jwdzj	152	3	approach	approach	NN
cord-277417-f71jwdzj	152	4	has	have	VBZ
cord-277417-f71jwdzj	152	5	a	a	DT
cord-277417-f71jwdzj	152	6	solid	solid	JJ
cord-277417-f71jwdzj	152	7	theoretical	theoretical	JJ
cord-277417-f71jwdzj	152	8	and	and	CC
cord-277417-f71jwdzj	152	9	empirical	empirical	JJ
cord-277417-f71jwdzj	152	10	basis	basis	NN
cord-277417-f71jwdzj	152	11	61,62	61,62	CD
cord-277417-f71jwdzj	152	12	,	,	,
cord-277417-f71jwdzj	152	13	a	a	DT
cord-277417-f71jwdzj	152	14	complicating	complicate	VBG
cord-277417-f71jwdzj	152	15	factor	factor	NN
cord-277417-f71jwdzj	152	16	is	be	VBZ
cord-277417-f71jwdzj	152	17	that	that	IN
cord-277417-f71jwdzj	152	18	a	a	DT
cord-277417-f71jwdzj	152	19	virulence	virulence	NN
cord-277417-f71jwdzj	152	20	-	-	HYPH
cord-277417-f71jwdzj	152	21	determining	determine	VBG
cord-277417-f71jwdzj	152	22	mutation	mutation	NN
cord-277417-f71jwdzj	152	23	that	that	WDT
cord-277417-f71jwdzj	152	24	has	have	VBZ
cord-277417-f71jwdzj	152	25	very	very	RB
cord-277417-f71jwdzj	152	26	recently	recently	RB
cord-277417-f71jwdzj	152	27	emerged	emerge	VBN
cord-277417-f71jwdzj	152	28	will	will	MD
cord-277417-f71jwdzj	152	29	necessarily	necessarily	RB
cord-277417-f71jwdzj	152	30	fall	fall	VB
cord-277417-f71jwdzj	152	31	towards	towards	IN
cord-277417-f71jwdzj	152	32	the	the	DT
cord-277417-f71jwdzj	152	33	tips	tip	NNS
cord-277417-f71jwdzj	152	34	rather	rather	RB
cord-277417-f71jwdzj	152	35	than	than	IN
cord-277417-f71jwdzj	152	36	on	on	IN
cord-277417-f71jwdzj	152	37	an	an	DT
cord-277417-f71jwdzj	152	38	internal	internal	JJ
cord-277417-f71jwdzj	152	39	branch	branch	NN
cord-277417-f71jwdzj	152	40	even	even	RB
cord-277417-f71jwdzj	152	41	if	if	IN
cord-277417-f71jwdzj	152	42	it	-PRON-	PRP
cord-277417-f71jwdzj	152	43	is	be	VBZ
cord-277417-f71jwdzj	152	44	selectively	selectively	RB
cord-277417-f71jwdzj	152	45	advantageous	advantageous	JJ
cord-277417-f71jwdzj	152	46	.	.	.
cord-277417-f71jwdzj	153	1	Similarly	similarly	RB
cord-277417-f71jwdzj	153	2	,	,	,
cord-277417-f71jwdzj	153	3	although	although	IN
cord-277417-f71jwdzj	153	4	popular	popular	JJ
cord-277417-f71jwdzj	153	5	,	,	,
cord-277417-f71jwdzj	153	6	d	d	XX
cord-277417-f71jwdzj	154	1	N	N	NNP
cord-277417-f71jwdzj	154	2	/d	/d	NNP
cord-277417-f71jwdzj	154	3	S	S	NNP
cord-277417-f71jwdzj	154	4	measures	measure	NNS
cord-277417-f71jwdzj	154	5	are	be	VBP
cord-277417-f71jwdzj	154	6	less	less	RBR
cord-277417-f71jwdzj	154	7	robust	robust	JJ
cord-277417-f71jwdzj	154	8	over	over	IN
cord-277417-f71jwdzj	154	9	short	short	JJ
cord-277417-f71jwdzj	154	10	timescales	timescale	NNS
cord-277417-f71jwdzj	154	11	,	,	,
cord-277417-f71jwdzj	154	12	such	such	JJ
cord-277417-f71jwdzj	154	13	as	as	IN
cord-277417-f71jwdzj	154	14	during	during	IN
cord-277417-f71jwdzj	154	15	outbreaks	outbreak	NNS
cord-277417-f71jwdzj	154	16	,	,	,
cord-277417-f71jwdzj	154	17	because	because	IN
cord-277417-f71jwdzj	154	18	mutations	mutation	NNS
cord-277417-f71jwdzj	154	19	may	may	MD
cord-277417-f71jwdzj	154	20	not	not	RB
cord-277417-f71jwdzj	154	21	have	have	VB
cord-277417-f71jwdzj	154	22	reached	reach	VBN
cord-277417-f71jwdzj	154	23	fixation	fixation	NN
cord-277417-f71jwdzj	154	24	by	by	IN
cord-277417-f71jwdzj	154	25	positive	positive	JJ
cord-277417-f71jwdzj	154	26	selection	selection	NN
cord-277417-f71jwdzj	154	27	or	or	CC
cord-277417-f71jwdzj	154	28	had	have	VBD
cord-277417-f71jwdzj	154	29	time	time	NN
cord-277417-f71jwdzj	154	30	to	to	TO
cord-277417-f71jwdzj	154	31	be	be	VB
cord-277417-f71jwdzj	154	32	purged	purge	VBN
cord-277417-f71jwdzj	154	33	by	by	IN
cord-277417-f71jwdzj	154	34	purifying	purify	VBG
cord-277417-f71jwdzj	154	35	selection	selection	NN
cord-277417-f71jwdzj	154	36	,	,	,
cord-277417-f71jwdzj	154	37	and	and	CC
cord-277417-f71jwdzj	154	38	it	-PRON-	PRP
cord-277417-f71jwdzj	154	39	can	can	MD
cord-277417-f71jwdzj	154	40	be	be	VB
cord-277417-f71jwdzj	154	41	difficult	difficult	JJ
cord-277417-f71jwdzj	154	42	to	to	TO
cord-277417-f71jwdzj	154	43	detect	detect	VB
cord-277417-f71jwdzj	154	44	selected	select	VBN
cord-277417-f71jwdzj	154	45	mutations	mutation	NNS
cord-277417-f71jwdzj	154	46	that	that	WDT
cord-277417-f71jwdzj	154	47	occur	occur	VBP
cord-277417-f71jwdzj	154	48	only	only	RB
cord-277417-f71jwdzj	154	49	once	once	RB
cord-277417-f71jwdzj	154	50	63	63	CD
cord-277417-f71jwdzj	154	51	,	,	,
cord-277417-f71jwdzj	154	52	64	64	CD
cord-277417-f71jwdzj	154	53	.	.	.
cord-277417-f71jwdzj	155	1	Approaches	approach	NNS
cord-277417-f71jwdzj	155	2	to	to	TO
cord-277417-f71jwdzj	155	3	detect	detect	VB
cord-277417-f71jwdzj	155	4	positive	positive	JJ
cord-277417-f71jwdzj	155	5	selection	selection	NN
cord-277417-f71jwdzj	155	6	that	that	WDT
cord-277417-f71jwdzj	155	7	do	do	VBP
cord-277417-f71jwdzj	155	8	not	not	RB
cord-277417-f71jwdzj	155	9	rely	rely	VB
cord-277417-f71jwdzj	155	10	on	on	IN
cord-277417-f71jwdzj	155	11	d	d	NNP
cord-277417-f71jwdzj	155	12	N	N	NNP
cord-277417-f71jwdzj	155	13	/d	/d	NNP
cord-277417-f71jwdzj	155	14	S	S	NNP
cord-277417-f71jwdzj	155	15	,	,	,
cord-277417-f71jwdzj	155	16	such	such	JJ
cord-277417-f71jwdzj	155	17	as	as	IN
cord-277417-f71jwdzj	155	18	those	those	DT
cord-277417-f71jwdzj	155	19	based	base	VBN
cord-277417-f71jwdzj	155	20	on	on	IN
cord-277417-f71jwdzj	155	21	tree	tree	NN
cord-277417-f71jwdzj	155	22	shape	shape	NN
cord-277417-f71jwdzj	155	23	24	24	CD
cord-277417-f71jwdzj	155	24	,	,	,
cord-277417-f71jwdzj	155	25	or	or	CC
cord-277417-f71jwdzj	155	26	tracking	tracking	NN
cord-277417-f71jwdzj	155	27	mutations	mutation	NNS
cord-277417-f71jwdzj	155	28	that	that	WDT
cord-277417-f71jwdzj	155	29	are	be	VBP
cord-277417-f71jwdzj	155	30	increasing	increase	VBG
cord-277417-f71jwdzj	155	31	in	in	IN
cord-277417-f71jwdzj	155	32	frequency	frequency	NN
cord-277417-f71jwdzj	155	33	compared	compare	VBN
cord-277417-f71jwdzj	155	34	with	with	IN
cord-277417-f71jwdzj	155	35	those	those	DT
cord-277417-f71jwdzj	155	36	thought	thought	NN
cord-277417-f71jwdzj	155	37	to	to	TO
cord-277417-f71jwdzj	155	38	be	be	VB
cord-277417-f71jwdzj	155	39	evolving	evolve	VBG
cord-277417-f71jwdzj	155	40	neutrally	neutrally	RB
cord-277417-f71jwdzj	155	41	64	64	CD
cord-277417-f71jwdzj	155	42	,	,	,
cord-277417-f71jwdzj	155	43	65	65	CD
cord-277417-f71jwdzj	155	44	,	,	,
cord-277417-f71jwdzj	155	45	may	may	MD
cord-277417-f71jwdzj	155	46	therefore	therefore	RB
cord-277417-f71jwdzj	155	47	add	add	VB
cord-277417-f71jwdzj	155	48	analytical	analytical	JJ
cord-277417-f71jwdzj	155	49	power	power	NN
cord-277417-f71jwdzj	155	50	.	.	.
cord-277417-f71jwdzj	156	1	The	the	DT
cord-277417-f71jwdzj	156	2	phylogenetic	phylogenetic	JJ
cord-277417-f71jwdzj	156	3	mapping	mapping	NN
cord-277417-f71jwdzj	156	4	of	of	IN
cord-277417-f71jwdzj	156	5	virulence	virulence	NN
cord-277417-f71jwdzj	156	6	mutations	mutation	NNS
cord-277417-f71jwdzj	156	7	can	can	MD
cord-277417-f71jwdzj	156	8	proceed	proceed	VB
cord-277417-f71jwdzj	156	9	in	in	IN
cord-277417-f71jwdzj	156	10	two	two	CD
cord-277417-f71jwdzj	156	11	ways	way	NNS
cord-277417-f71jwdzj	156	12	depending	depend	VBG
cord-277417-f71jwdzj	156	13	on	on	IN
cord-277417-f71jwdzj	156	14	the	the	DT
cord-277417-f71jwdzj	156	15	extent	extent	NN
cord-277417-f71jwdzj	156	16	of	of	IN
cord-277417-f71jwdzj	156	17	a	a	DT
cord-277417-f71jwdzj	156	18	priori	priori	FW
cord-277417-f71jwdzj	156	19	knowledge	knowledge	NN
cord-277417-f71jwdzj	156	20	.	.	.
cord-277417-f71jwdzj	157	1	In	in	IN
cord-277417-f71jwdzj	157	2	a	a	DT
cord-277417-f71jwdzj	157	3	'	'	``
cord-277417-f71jwdzj	157	4	top	top	JJ
cord-277417-f71jwdzj	157	5	-	-	HYPH
cord-277417-f71jwdzj	157	6	down	down	NN
cord-277417-f71jwdzj	157	7	'	'	''
cord-277417-f71jwdzj	157	8	approach	approach	NN
cord-277417-f71jwdzj	157	9	,	,	,
cord-277417-f71jwdzj	157	10	in	in	IN
cord-277417-f71jwdzj	157	11	which	which	WDT
cord-277417-f71jwdzj	157	12	virulence	virulence	NN
cord-277417-f71jwdzj	157	13	determinants	determinant	NNS
cord-277417-f71jwdzj	157	14	are	be	VBP
cord-277417-f71jwdzj	157	15	unknown	unknown	JJ
cord-277417-f71jwdzj	157	16	,	,	,
cord-277417-f71jwdzj	157	17	a	a	DT
cord-277417-f71jwdzj	157	18	virus	virus	NN
cord-277417-f71jwdzj	157	19	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	157	20	is	be	VBZ
cord-277417-f71jwdzj	157	21	inferred	infer	VBN
cord-277417-f71jwdzj	157	22	,	,	,
cord-277417-f71jwdzj	157	23	mutations	mutation	NNS
cord-277417-f71jwdzj	157	24	are	be	VBP
cord-277417-f71jwdzj	157	25	mapped	map	VBN
cord-277417-f71jwdzj	157	26	onto	onto	IN
cord-277417-f71jwdzj	157	27	this	this	DT
cord-277417-f71jwdzj	157	28	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	157	29	and	and	CC
cord-277417-f71jwdzj	157	30	the	the	DT
cord-277417-f71jwdzj	157	31	mutations	mutation	NNS
cord-277417-f71jwdzj	157	32	on	on	IN
cord-277417-f71jwdzj	157	33	key	key	JJ
cord-277417-f71jwdzj	157	34	branches	branch	NNS
cord-277417-f71jwdzj	157	35	are	be	VBP
cord-277417-f71jwdzj	157	36	then	then	RB
cord-277417-f71jwdzj	157	37	identified	identify	VBN
cord-277417-f71jwdzj	157	38	.	.	.
cord-277417-f71jwdzj	158	1	Such	such	JJ
cord-277417-f71jwdzj	158	2	'	'	POS
cord-277417-f71jwdzj	158	3	key	key	JJ
cord-277417-f71jwdzj	158	4	branches	branch	NNS
cord-277417-f71jwdzj	158	5	'	'	''
cord-277417-f71jwdzj	158	6	include	include	VBP
cord-277417-f71jwdzj	158	7	those	those	DT
cord-277417-f71jwdzj	158	8	directly	directly	RB
cord-277417-f71jwdzj	158	9	associated	associate	VBN
cord-277417-f71jwdzj	158	10	with	with	IN
cord-277417-f71jwdzj	158	11	cross	cross	JJ
cord-277417-f71jwdzj	158	12	-	-	JJ
cord-277417-f71jwdzj	158	13	species	species	JJ
cord-277417-f71jwdzj	158	14	transmission	transmission	NN
cord-277417-f71jwdzj	158	15	events	event	NNS
cord-277417-f71jwdzj	158	16	,	,	,
cord-277417-f71jwdzj	158	17	invasions	invasion	NNS
cord-277417-f71jwdzj	158	18	of	of	IN
cord-277417-f71jwdzj	158	19	new	new	JJ
cord-277417-f71jwdzj	158	20	geographic	geographic	JJ
cord-277417-f71jwdzj	158	21	areas	area	NNS
cord-277417-f71jwdzj	158	22	,	,	,
cord-277417-f71jwdzj	158	23	increases	increase	NNS
cord-277417-f71jwdzj	158	24	in	in	IN
cord-277417-f71jwdzj	158	25	rates	rate	NNS
cord-277417-f71jwdzj	158	26	of	of	IN
cord-277417-f71jwdzj	158	27	transmission	transmission	NN
cord-277417-f71jwdzj	158	28	,	,	,
cord-277417-f71jwdzj	158	29	spikes	spike	NNS
cord-277417-f71jwdzj	158	30	in	in	IN
cord-277417-f71jwdzj	158	31	morbidity	morbidity	NN
cord-277417-f71jwdzj	158	32	and/or	and/or	CC
cord-277417-f71jwdzj	158	33	mortality	mortality	NN
cord-277417-f71jwdzj	158	34	or	or	CC
cord-277417-f71jwdzj	158	35	clear	clear	JJ
cord-277417-f71jwdzj	158	36	instances	instance	NNS
cord-277417-f71jwdzj	158	37	of	of	IN
cord-277417-f71jwdzj	158	38	positive	positive	JJ
cord-277417-f71jwdzj	158	39	selection	selection	NN
cord-277417-f71jwdzj	158	40	.	.	.
cord-277417-f71jwdzj	159	1	The	the	DT
cord-277417-f71jwdzj	159	2	mutations	mutation	NNS
cord-277417-f71jwdzj	159	3	identified	identify	VBN
cord-277417-f71jwdzj	159	4	in	in	IN
cord-277417-f71jwdzj	159	5	this	this	DT
cord-277417-f71jwdzj	159	6	way	way	NN
cord-277417-f71jwdzj	159	7	are	be	VBP
cord-277417-f71jwdzj	159	8	candidates	candidate	NNS
cord-277417-f71jwdzj	159	9	for	for	IN
cord-277417-f71jwdzj	159	10	virulence	virulence	NN
cord-277417-f71jwdzj	159	11	determinants	determinant	NNS
cord-277417-f71jwdzj	159	12	that	that	WDT
cord-277417-f71jwdzj	159	13	can	can	MD
cord-277417-f71jwdzj	159	14	be	be	VB
cord-277417-f71jwdzj	159	15	tested	test	VBN
cord-277417-f71jwdzj	159	16	in	in	IN
cord-277417-f71jwdzj	159	17	an	an	DT
cord-277417-f71jwdzj	159	18	appropriate	appropriate	JJ
cord-277417-f71jwdzj	159	19	experimental	experimental	JJ
cord-277417-f71jwdzj	159	20	framework	framework	NN
cord-277417-f71jwdzj	159	21	8	8	CD
cord-277417-f71jwdzj	159	22	.	.	.
cord-277417-f71jwdzj	160	1	An	an	DT
cord-277417-f71jwdzj	160	2	example	example	NN
cord-277417-f71jwdzj	160	3	of	of	IN
cord-277417-f71jwdzj	160	4	this	this	DT
cord-277417-f71jwdzj	160	5	approach	approach	NN
cord-277417-f71jwdzj	160	6	is	be	VBZ
cord-277417-f71jwdzj	160	7	shown	show	VBN
cord-277417-f71jwdzj	160	8	in	in	IN
cord-277417-f71jwdzj	160	9	FIg	FIg	NNS
cord-277417-f71jwdzj	160	10	.	.	.
cord-277417-f71jwdzj	161	1	2	2	LS
cord-277417-f71jwdzj	161	2	.	.	.
cord-277417-f71jwdzj	162	1	The	the	DT
cord-277417-f71jwdzj	162	2	second	second	JJ
cord-277417-f71jwdzj	162	3	,	,	,
cord-277417-f71jwdzj	162	4	'	'	''
cord-277417-f71jwdzj	162	5	bottom	bottom	NN
cord-277417-f71jwdzj	162	6	-	-	HYPH
cord-277417-f71jwdzj	162	7	up	up	NN
cord-277417-f71jwdzj	162	8	'	'	''
cord-277417-f71jwdzj	162	9	,	,	,
cord-277417-f71jwdzj	162	10	approach	approach	NN
cord-277417-f71jwdzj	162	11	utilizes	utilize	VBZ
cord-277417-f71jwdzj	162	12	existing	exist	VBG
cord-277417-f71jwdzj	162	13	knowledge	knowledge	NN
cord-277417-f71jwdzj	162	14	of	of	IN
cord-277417-f71jwdzj	162	15	virulence	virulence	NN
cord-277417-f71jwdzj	162	16	determinants	determinant	NNS
cord-277417-f71jwdzj	162	17	,	,	,
cord-277417-f71jwdzj	162	18	such	such	JJ
cord-277417-f71jwdzj	162	19	as	as	IN
cord-277417-f71jwdzj	162	20	that	that	DT
cord-277417-f71jwdzj	162	21	determined	determine	VBN
cord-277417-f71jwdzj	162	22	by	by	IN
cord-277417-f71jwdzj	162	23	an	an	DT
cord-277417-f71jwdzj	162	24	experimental	experimental	JJ
cord-277417-f71jwdzj	162	25	study	study	NN
cord-277417-f71jwdzj	162	26	.	.	.
cord-277417-f71jwdzj	163	1	The	the	DT
cord-277417-f71jwdzj	163	2	putative	putative	JJ
cord-277417-f71jwdzj	163	3	virulence	virulence	NN
cord-277417-f71jwdzj	163	4	determinant	determinant	NN
cord-277417-f71jwdzj	163	5	is	be	VBZ
cord-277417-f71jwdzj	163	6	then	then	RB
cord-277417-f71jwdzj	163	7	mapped	map	VBN
cord-277417-f71jwdzj	163	8	onto	onto	IN
cord-277417-f71jwdzj	163	9	the	the	DT
cord-277417-f71jwdzj	163	10	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	163	11	,	,	,
cord-277417-f71jwdzj	163	12	and	and	CC
cord-277417-f71jwdzj	163	13	its	-PRON-	PRP$
cord-277417-f71jwdzj	163	14	phylogenetic	phylogenetic	JJ
cord-277417-f71jwdzj	163	15	location	location	NN
cord-277417-f71jwdzj	163	16	(	(	-LRB-
cord-277417-f71jwdzj	163	17	that	that	RB
cord-277417-f71jwdzj	163	18	is	is	RB
cord-277417-f71jwdzj	163	19	,	,	,
cord-277417-f71jwdzj	163	20	deep	deep	JJ
cord-277417-f71jwdzj	163	21	or	or	CC
cord-277417-f71jwdzj	163	22	shallow	shallow	JJ
cord-277417-f71jwdzj	163	23	branch	branch	NN
cord-277417-f71jwdzj	163	24	,	,	,
cord-277417-f71jwdzj	163	25	singular	singular	JJ
cord-277417-f71jwdzj	163	26	or	or	CC
cord-277417-f71jwdzj	163	27	parallel	parallel	JJ
cord-277417-f71jwdzj	163	28	/	/	SYM
cord-277417-f71jwdzj	163	29	convergent	convergent	JJ
cord-277417-f71jwdzj	163	30	evolution	evolution	NN
cord-277417-f71jwdzj	163	31	)	)	-RRB-
cord-277417-f71jwdzj	163	32	is	be	VBZ
cord-277417-f71jwdzj	163	33	used	use	VBN
cord-277417-f71jwdzj	163	34	to	to	TO
cord-277417-f71jwdzj	163	35	infer	infer	VB
cord-277417-f71jwdzj	163	36	how	how	WRB
cord-277417-f71jwdzj	163	37	it	-PRON-	PRP
cord-277417-f71jwdzj	163	38	affects	affect	VBZ
cord-277417-f71jwdzj	163	39	virulence	virulence	NN
cord-277417-f71jwdzj	163	40	evolution	evolution	NN
cord-277417-f71jwdzj	163	41	,	,	,
cord-277417-f71jwdzj	163	42	whether	whether	IN
cord-277417-f71jwdzj	163	43	it	-PRON-	PRP
cord-277417-f71jwdzj	163	44	is	be	VBZ
cord-277417-f71jwdzj	163	45	associated	associate	VBN
cord-277417-f71jwdzj	163	46	with	with	IN
cord-277417-f71jwdzj	163	47	reciprocal	reciprocal	JJ
cord-277417-f71jwdzj	163	48	mutations	mutation	NNS
cord-277417-f71jwdzj	163	49	that	that	WDT
cord-277417-f71jwdzj	163	50	reflect	reflect	VBP
cord-277417-f71jwdzj	163	51	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	163	52	trade	trade	NN
cord-277417-f71jwdzj	163	53	-	-	HYPH
cord-277417-f71jwdzj	163	54	offs	off	NNS
cord-277417-f71jwdzj	163	55	and	and	CC
cord-277417-f71jwdzj	163	56	the	the	DT
cord-277417-f71jwdzj	163	57	selection	selection	NN
cord-277417-f71jwdzj	163	58	pressures	pressure	VBZ
cord-277417-f71jwdzj	163	59	it	-PRON-	PRP
cord-277417-f71jwdzj	163	60	faces	face	VBZ
cord-277417-f71jwdzj	163	61	.	.	.
cord-277417-f71jwdzj	164	1	Although	although	IN
cord-277417-f71jwdzj	164	2	this	this	DT
cord-277417-f71jwdzj	164	3	phylogenomic	phylogenomic	JJ
cord-277417-f71jwdzj	164	4	approach	approach	NN
cord-277417-f71jwdzj	164	5	is	be	VBZ
cord-277417-f71jwdzj	164	6	being	be	VBG
cord-277417-f71jwdzj	164	7	increasingly	increasingly	RB
cord-277417-f71jwdzj	164	8	used	use	VBN
cord-277417-f71jwdzj	164	9	to	to	TO
cord-277417-f71jwdzj	164	10	identify	identify	VB
cord-277417-f71jwdzj	164	11	virulence	virulence	NN
cord-277417-f71jwdzj	164	12	determinants	determinant	NNS
cord-277417-f71jwdzj	164	13	,	,	,
cord-277417-f71jwdzj	164	14	and	and	CC
cord-277417-f71jwdzj	164	15	we	-PRON-	PRP
cord-277417-f71jwdzj	164	16	discuss	discuss	VBP
cord-277417-f71jwdzj	164	17	a	a	DT
cord-277417-f71jwdzj	164	18	number	number	NN
cord-277417-f71jwdzj	164	19	of	of	IN
cord-277417-f71jwdzj	164	20	real	real	JJ
cord-277417-f71jwdzj	164	21	data	datum	NNS
cord-277417-f71jwdzj	164	22	examples	example	NNS
cord-277417-f71jwdzj	164	23	below	below	RB
cord-277417-f71jwdzj	164	24	,	,	,
cord-277417-f71jwdzj	164	25	it	-PRON-	PRP
cord-277417-f71jwdzj	164	26	can	can	MD
cord-277417-f71jwdzj	164	27	be	be	VB
cord-277417-f71jwdzj	164	28	used	use	VBN
cord-277417-f71jwdzj	164	29	to	to	TO
cord-277417-f71jwdzj	164	30	make	make	VB
cord-277417-f71jwdzj	164	31	general	general	JJ
cord-277417-f71jwdzj	164	32	statements	statement	NNS
cord-277417-f71jwdzj	164	33	about	about	IN
cord-277417-f71jwdzj	164	34	the	the	DT
cord-277417-f71jwdzj	164	35	nature	nature	NN
cord-277417-f71jwdzj	164	36	of	of	IN
cord-277417-f71jwdzj	164	37	virulence	virulence	NN
cord-277417-f71jwdzj	164	38	evolution	evolution	NN
cord-277417-f71jwdzj	164	39	.	.	.
cord-277417-f71jwdzj	165	1	Specifically	specifically	RB
cord-277417-f71jwdzj	165	2	,	,	,
cord-277417-f71jwdzj	165	3	a	a	DT
cord-277417-f71jwdzj	165	4	virulence	virulence	NN
cord-277417-f71jwdzj	165	5	mutation	mutation	NN
cord-277417-f71jwdzj	165	6	that	that	WDT
cord-277417-f71jwdzj	165	7	falls	fall	VBZ
cord-277417-f71jwdzj	165	8	deep	deep	RB
cord-277417-f71jwdzj	165	9	in	in	IN
cord-277417-f71jwdzj	165	10	the	the	DT
cord-277417-f71jwdzj	165	11	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	165	12	such	such	JJ
cord-277417-f71jwdzj	165	13	that	that	IN
cord-277417-f71jwdzj	165	14	it	-PRON-	PRP
cord-277417-f71jwdzj	165	15	is	be	VBZ
cord-277417-f71jwdzj	165	16	inherited	inherit	VBN
cord-277417-f71jwdzj	165	17	in	in	IN
cord-277417-f71jwdzj	165	18	all	all	DT
cord-277417-f71jwdzj	165	19	subsequent	subsequent	JJ
cord-277417-f71jwdzj	165	20	branches	branch	NNS
cord-277417-f71jwdzj	165	21	,	,	,
cord-277417-f71jwdzj	165	22	and	and	CC
cord-277417-f71jwdzj	165	23	one	one	CD
cord-277417-f71jwdzj	165	24	evolving	evolve	VBG
cord-277417-f71jwdzj	165	25	in	in	IN
cord-277417-f71jwdzj	165	26	parallel	parallel	NN
cord-277417-f71jwdzj	165	27	or	or	CC
cord-277417-f71jwdzj	165	28	with	with	IN
cord-277417-f71jwdzj	165	29	evidence	evidence	NN
cord-277417-f71jwdzj	165	30	of	of	IN
cord-277417-f71jwdzj	165	31	positive	positive	JJ
cord-277417-f71jwdzj	165	32	selection	selection	NN
cord-277417-f71jwdzj	165	33	,	,	,
cord-277417-f71jwdzj	165	34	necessarily	necessarily	RB
cord-277417-f71jwdzj	165	35	implies	imply	VBZ
cord-277417-f71jwdzj	165	36	that	that	IN
cord-277417-f71jwdzj	165	37	virulence	virulence	NN
cord-277417-f71jwdzj	165	38	is	be	VBZ
cord-277417-f71jwdzj	165	39	selectively	selectively	RB
cord-277417-f71jwdzj	165	40	advantageous	advantageous	JJ
cord-277417-f71jwdzj	165	41	.	.	.
cord-277417-f71jwdzj	166	1	Conversely	conversely	RB
cord-277417-f71jwdzj	166	2	,	,	,
cord-277417-f71jwdzj	166	3	a	a	DT
cord-277417-f71jwdzj	166	4	virulence	virulence	NN
cord-277417-f71jwdzj	166	5	determinant	determinant	NN
cord-277417-f71jwdzj	166	6	that	that	WDT
cord-277417-f71jwdzj	166	7	occurs	occur	VBZ
cord-277417-f71jwdzj	166	8	sporadically	sporadically	RB
cord-277417-f71jwdzj	166	9	on	on	IN
cord-277417-f71jwdzj	166	10	shallow	shallow	JJ
cord-277417-f71jwdzj	166	11	branches	branch	NNS
cord-277417-f71jwdzj	166	12	and	and	CC
cord-277417-f71jwdzj	166	13	is	be	VBZ
cord-277417-f71jwdzj	166	14	subject	subject	JJ
cord-277417-f71jwdzj	166	15	to	to	IN
cord-277417-f71jwdzj	166	16	strong	strong	JJ
cord-277417-f71jwdzj	166	17	purifying	purifying	NN
cord-277417-f71jwdzj	166	18	(	(	-LRB-
cord-277417-f71jwdzj	166	19	negative	negative	JJ
cord-277417-f71jwdzj	166	20	)	)	-RRB-
cord-277417-f71jwdzj	166	21	selection	selection	NN
cord-277417-f71jwdzj	166	22	suggests	suggest	VBZ
cord-277417-f71jwdzj	166	23	that	that	IN
cord-277417-f71jwdzj	166	24	virulence	virulence	NN
cord-277417-f71jwdzj	166	25	is	be	VBZ
cord-277417-f71jwdzj	166	26	not	not	RB
cord-277417-f71jwdzj	166	27	directly	directly	RB
cord-277417-f71jwdzj	166	28	beneficial	beneficial	JJ
cord-277417-f71jwdzj	166	29	,	,	,
cord-277417-f71jwdzj	166	30	probably	probably	RB
cord-277417-f71jwdzj	166	31	because	because	IN
cord-277417-f71jwdzj	166	32	it	-PRON-	PRP
cord-277417-f71jwdzj	166	33	inhibits	inhibit	VBZ
cord-277417-f71jwdzj	166	34	some	some	DT
cord-277417-f71jwdzj	166	35	other	other	JJ
cord-277417-f71jwdzj	166	36	component	component	NN
cord-277417-f71jwdzj	166	37	of	of	IN
cord-277417-f71jwdzj	166	38	overall	overall	JJ
cord-277417-f71jwdzj	166	39	fitness	fitness	NN
cord-277417-f71jwdzj	166	40	.	.	.
cord-277417-f71jwdzj	167	1	In	in	IN
cord-277417-f71jwdzj	167	2	such	such	JJ
cord-277417-f71jwdzj	167	3	cases	case	NNS
cord-277417-f71jwdzj	167	4	,	,	,
cord-277417-f71jwdzj	167	5	each	each	DT
cord-277417-f71jwdzj	167	6	instance	instance	NN
cord-277417-f71jwdzj	167	7	of	of	IN
cord-277417-f71jwdzj	167	8	high	high	JJ
cord-277417-f71jwdzj	167	9	virulence	virulence	NN
cord-277417-f71jwdzj	167	10	may	may	MD
cord-277417-f71jwdzj	167	11	represent	represent	VB
cord-277417-f71jwdzj	167	12	an	an	DT
cord-277417-f71jwdzj	167	13	independent	independent	JJ
cord-277417-f71jwdzj	167	14	and	and	CC
cord-277417-f71jwdzj	167	15	transient	transient	JJ
cord-277417-f71jwdzj	167	16	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	167	17	event	event	NN
cord-277417-f71jwdzj	167	18	.	.	.
cord-277417-f71jwdzj	168	1	If	if	IN
cord-277417-f71jwdzj	168	2	only	only	RB
cord-277417-f71jwdzj	168	3	a	a	DT
cord-277417-f71jwdzj	168	4	single	single	JJ
cord-277417-f71jwdzj	168	5	mutation	mutation	NN
cord-277417-f71jwdzj	168	6	is	be	VBZ
cord-277417-f71jwdzj	168	7	associated	associate	VBN
cord-277417-f71jwdzj	168	8	with	with	IN
cord-277417-f71jwdzj	168	9	a	a	DT
cord-277417-f71jwdzj	168	10	change	change	NN
cord-277417-f71jwdzj	168	11	in	in	IN
cord-277417-f71jwdzj	168	12	virus	virus	NN
cord-277417-f71jwdzj	168	13	virulence	virulence	NN
cord-277417-f71jwdzj	168	14	,	,	,
cord-277417-f71jwdzj	168	15	as	as	IN
cord-277417-f71jwdzj	168	16	in	in	IN
cord-277417-f71jwdzj	168	17	the	the	DT
cord-277417-f71jwdzj	168	18	case	case	NN
cord-277417-f71jwdzj	168	19	of	of	IN
cord-277417-f71jwdzj	168	20	WNV	WNV	NNP
cord-277417-f71jwdzj	168	21	,	,	,
cord-277417-f71jwdzj	168	22	then	then	RB
cord-277417-f71jwdzj	168	23	this	this	DT
cord-277417-f71jwdzj	168	24	change	change	NN
cord-277417-f71jwdzj	168	25	in	in	IN
cord-277417-f71jwdzj	168	26	virulence	virulence	NN
cord-277417-f71jwdzj	168	27	is	be	VBZ
cord-277417-f71jwdzj	168	28	likely	likely	JJ
cord-277417-f71jwdzj	168	29	to	to	TO
cord-277417-f71jwdzj	168	30	be	be	VB
cord-277417-f71jwdzj	168	31	selectively	selectively	RB
cord-277417-f71jwdzj	168	32	advantageous	advantageous	JJ
cord-277417-f71jwdzj	168	33	without	without	IN
cord-277417-f71jwdzj	168	34	an	an	DT
cord-277417-f71jwdzj	168	35	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	168	36	trade	trade	NN
cord-277417-f71jwdzj	168	37	-	-	HYPH
cord-277417-f71jwdzj	168	38	off	off	NN
cord-277417-f71jwdzj	168	39	with	with	IN
cord-277417-f71jwdzj	168	40	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	168	41	,	,	,
cord-277417-f71jwdzj	168	42	as	as	IN
cord-277417-f71jwdzj	168	43	a	a	DT
cord-277417-f71jwdzj	168	44	reduction	reduction	NN
cord-277417-f71jwdzj	168	45	in	in	IN
cord-277417-f71jwdzj	168	46	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	168	47	would	would	MD
cord-277417-f71jwdzj	168	48	probably	probably	RB
cord-277417-f71jwdzj	168	49	need	need	VB
cord-277417-f71jwdzj	168	50	to	to	TO
cord-277417-f71jwdzj	168	51	be	be	VB
cord-277417-f71jwdzj	168	52	compensated	compensate	VBN
cord-277417-f71jwdzj	168	53	for	for	IN
cord-277417-f71jwdzj	168	54	by	by	IN
cord-277417-f71jwdzj	168	55	additional	additional	JJ
cord-277417-f71jwdzj	168	56	reciprocal	reciprocal	JJ
cord-277417-f71jwdzj	168	57	mutations	mutation	NNS
cord-277417-f71jwdzj	168	58	located	locate	VBN
cord-277417-f71jwdzj	168	59	elsewhere	elsewhere	RB
cord-277417-f71jwdzj	168	60	in	in	IN
cord-277417-f71jwdzj	168	61	the	the	DT
cord-277417-f71jwdzj	168	62	genome	genome	NN
cord-277417-f71jwdzj	168	63	.	.	.
cord-277417-f71jwdzj	169	1	Hence	hence	RB
cord-277417-f71jwdzj	169	2	,	,	,
cord-277417-f71jwdzj	169	3	if	if	IN
cord-277417-f71jwdzj	169	4	multiple	multiple	JJ
cord-277417-f71jwdzj	169	5	mutations	mutation	NNS
cord-277417-f71jwdzj	169	6	fall	fall	VBP
cord-277417-f71jwdzj	169	7	on	on	IN
cord-277417-f71jwdzj	169	8	a	a	DT
cord-277417-f71jwdzj	169	9	branch	branch	NN
cord-277417-f71jwdzj	169	10	associated	associate	VBN
cord-277417-f71jwdzj	169	11	with	with	IN
cord-277417-f71jwdzj	169	12	a	a	DT
cord-277417-f71jwdzj	169	13	change	change	NN
cord-277417-f71jwdzj	169	14	in	in	IN
cord-277417-f71jwdzj	169	15	virulence	virulence	NN
cord-277417-f71jwdzj	169	16	,	,	,
cord-277417-f71jwdzj	169	17	it	-PRON-	PRP
cord-277417-f71jwdzj	169	18	is	be	VBZ
cord-277417-f71jwdzj	169	19	possible	possible	JJ
cord-277417-f71jwdzj	169	20	that	that	IN
cord-277417-f71jwdzj	169	21	some	some	DT
cord-277417-f71jwdzj	169	22	are	be	VBP
cord-277417-f71jwdzj	169	23	virulence	virulence	NN
cord-277417-f71jwdzj	169	24	determinants	determinant	NNS
cord-277417-f71jwdzj	169	25	and	and	CC
cord-277417-f71jwdzj	169	26	the	the	DT
cord-277417-f71jwdzj	169	27	others	other	NNS
cord-277417-f71jwdzj	169	28	are	be	VBP
cord-277417-f71jwdzj	169	29	associated	associate	VBN
cord-277417-f71jwdzj	169	30	with	with	IN
cord-277417-f71jwdzj	169	31	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	169	32	trade	trade	NN
cord-277417-f71jwdzj	169	33	-	-	HYPH
cord-277417-f71jwdzj	169	34	offs	off	NNS
cord-277417-f71jwdzj	169	35	on	on	IN
cord-277417-f71jwdzj	169	36	other	other	JJ
cord-277417-f71jwdzj	169	37	traits	trait	NNS
cord-277417-f71jwdzj	169	38	.	.	.
cord-277417-f71jwdzj	170	1	Although	although	IN
cord-277417-f71jwdzj	170	2	we	-PRON-	PRP
cord-277417-f71jwdzj	170	3	have	have	VBP
cord-277417-f71jwdzj	170	4	described	describe	VBN
cord-277417-f71jwdzj	170	5	it	-PRON-	PRP
cord-277417-f71jwdzj	170	6	in	in	IN
cord-277417-f71jwdzj	170	7	terms	term	NNS
cord-277417-f71jwdzj	170	8	of	of	IN
cord-277417-f71jwdzj	170	9	emerging	emerge	VBG
cord-277417-f71jwdzj	170	10	viruses	virus	NNS
cord-277417-f71jwdzj	170	11	,	,	,
cord-277417-f71jwdzj	170	12	this	this	DT
cord-277417-f71jwdzj	170	13	phylogenomic	phylogenomic	JJ
cord-277417-f71jwdzj	170	14	approach	approach	NN
cord-277417-f71jwdzj	170	15	can	can	MD
cord-277417-f71jwdzj	170	16	,	,	,
cord-277417-f71jwdzj	170	17	in	in	IN
cord-277417-f71jwdzj	170	18	theory	theory	NN
cord-277417-f71jwdzj	170	19	,	,	,
cord-277417-f71jwdzj	170	20	be	be	VB
cord-277417-f71jwdzj	170	21	applied	apply	VBN
cord-277417-f71jwdzj	170	22	to	to	IN
cord-277417-f71jwdzj	170	23	any	any	DT
cord-277417-f71jwdzj	170	24	system	system	NN
cord-277417-f71jwdzj	170	25	in	in	IN
cord-277417-f71jwdzj	170	26	which	which	WDT
cord-277417-f71jwdzj	170	27	a	a	DT
cord-277417-f71jwdzj	170	28	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	170	29	can	can	MD
cord-277417-f71jwdzj	170	30	be	be	VB
cord-277417-f71jwdzj	170	31	inferred	infer	VBN
cord-277417-f71jwdzj	170	32	and	and	CC
cord-277417-f71jwdzj	170	33	in	in	IN
cord-277417-f71jwdzj	170	34	which	which	WDT
cord-277417-f71jwdzj	170	35	it	-PRON-	PRP
cord-277417-f71jwdzj	170	36	is	be	VBZ
cord-277417-f71jwdzj	170	37	possible	possible	JJ
cord-277417-f71jwdzj	170	38	to	to	TO
cord-277417-f71jwdzj	170	39	experimentally	experimentally	RB
cord-277417-f71jwdzj	170	40	assess	assess	VB
cord-277417-f71jwdzj	170	41	the	the	DT
cord-277417-f71jwdzj	170	42	impact	impact	NN
cord-277417-f71jwdzj	170	43	of	of	IN
cord-277417-f71jwdzj	170	44	individual	individual	JJ
cord-277417-f71jwdzj	170	45	mutations	mutation	NNS
cord-277417-f71jwdzj	170	46	on	on	IN
cord-277417-f71jwdzj	170	47	virulence	virulence	NN
cord-277417-f71jwdzj	170	48	.	.	.
cord-277417-f71jwdzj	171	1	Similarly	similarly	RB
cord-277417-f71jwdzj	171	2	,	,	,
cord-277417-f71jwdzj	171	3	it	-PRON-	PRP
cord-277417-f71jwdzj	171	4	can	can	MD
cord-277417-f71jwdzj	171	5	be	be	VB
cord-277417-f71jwdzj	171	6	used	use	VBN
cord-277417-f71jwdzj	171	7	to	to	TO
cord-277417-f71jwdzj	171	8	study	study	VB
cord-277417-f71jwdzj	171	9	other	other	JJ
cord-277417-f71jwdzj	171	10	virological	virological	JJ
cord-277417-f71jwdzj	171	11	traits	trait	NNS
cord-277417-f71jwdzj	171	12	associated	associate	VBN
cord-277417-f71jwdzj	171	13	with	with	IN
cord-277417-f71jwdzj	171	14	disease	disease	NN
cord-277417-f71jwdzj	171	15	emergence	emergence	NN
cord-277417-f71jwdzj	171	16	,	,	,
cord-277417-f71jwdzj	171	17	particularly	particularly	RB
cord-277417-f71jwdzj	171	18	host	host	NN
cord-277417-f71jwdzj	171	19	range	range	NN
cord-277417-f71jwdzj	171	20	.	.	.
cord-277417-f71jwdzj	172	1	For	for	IN
cord-277417-f71jwdzj	172	2	example	example	NN
cord-277417-f71jwdzj	172	3	,	,	,
cord-277417-f71jwdzj	172	4	the	the	DT
cord-277417-f71jwdzj	172	5	repeated	repeat	VBN
cord-277417-f71jwdzj	172	6	evolution	evolution	NN
cord-277417-f71jwdzj	172	7	of	of	IN
cord-277417-f71jwdzj	172	8	the	the	DT
cord-277417-f71jwdzj	172	9	same	same	JJ
cord-277417-f71jwdzj	172	10	amino	amino	NN
cord-277417-f71jwdzj	172	11	acid	acid	NN
cord-277417-f71jwdzj	172	12	changes	change	NNS
cord-277417-f71jwdzj	172	13	following	follow	VBG
cord-277417-f71jwdzj	172	14	the	the	DT
cord-277417-f71jwdzj	172	15	cross	cross	NN
cord-277417-f71jwdzj	172	16	-	-	JJ
cord-277417-f71jwdzj	172	17	species	species	JJ
cord-277417-f71jwdzj	172	18	transmission	transmission	NN
cord-277417-f71jwdzj	172	19	of	of	IN
cord-277417-f71jwdzj	172	20	avian	avian	JJ
cord-277417-f71jwdzj	172	21	influenza	influenza	NN
cord-277417-f71jwdzj	172	22	virus	virus	NN
cord-277417-f71jwdzj	172	23	to	to	IN
cord-277417-f71jwdzj	172	24	humans	human	NNS
cord-277417-f71jwdzj	172	25	strongly	strongly	RB
cord-277417-f71jwdzj	172	26	suggests	suggest	VBZ
cord-277417-f71jwdzj	172	27	that	that	IN
cord-277417-f71jwdzj	172	28	they	-PRON-	PRP
cord-277417-f71jwdzj	172	29	directly	directly	RB
cord-277417-f71jwdzj	172	30	affect	affect	VBP
cord-277417-f71jwdzj	172	31	host	host	NN
cord-277417-f71jwdzj	172	32	range	range	NN
cord-277417-f71jwdzj	172	33	66	66	CD
cord-277417-f71jwdzj	172	34	,	,	,
cord-277417-f71jwdzj	172	35	and	and	CC
cord-277417-f71jwdzj	172	36	a	a	DT
cord-277417-f71jwdzj	172	37	similar	similar	JJ
cord-277417-f71jwdzj	172	38	approach	approach	NN
cord-277417-f71jwdzj	172	39	has	have	VBZ
cord-277417-f71jwdzj	172	40	been	be	VBN
cord-277417-f71jwdzj	172	41	used	use	VBN
cord-277417-f71jwdzj	172	42	to	to	TO
cord-277417-f71jwdzj	172	43	elucidate	elucidate	VB
cord-277417-f71jwdzj	172	44	the	the	DT
cord-277417-f71jwdzj	172	45	nature	nature	NN
cord-277417-f71jwdzj	172	46	of	of	IN
cord-277417-f71jwdzj	172	47	the	the	DT
cord-277417-f71jwdzj	172	48	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	172	49	arms	arm	NNS
cord-277417-f71jwdzj	172	50	race	race	NN
cord-277417-f71jwdzj	172	51	between	between	IN
cord-277417-f71jwdzj	172	52	viruses	virus	NNS
cord-277417-f71jwdzj	172	53	and	and	CC
cord-277417-f71jwdzj	172	54	their	-PRON-	PRP$
cord-277417-f71jwdzj	172	55	hosts	host	NNS
cord-277417-f71jwdzj	172	56	67	67	CD
cord-277417-f71jwdzj	172	57	,	,	,
cord-277417-f71jwdzj	172	58	68	68	CD
cord-277417-f71jwdzj	172	59	.	.	.
cord-277417-f71jwdzj	173	1	Critically	critically	RB
cord-277417-f71jwdzj	173	2	,	,	,
cord-277417-f71jwdzj	173	3	however	however	RB
cord-277417-f71jwdzj	173	4	,	,	,
cord-277417-f71jwdzj	173	5	the	the	DT
cord-277417-f71jwdzj	173	6	approach	approach	NN
cord-277417-f71jwdzj	173	7	described	describe	VBN
cord-277417-f71jwdzj	173	8	here	here	RB
cord-277417-f71jwdzj	173	9	should	should	MD
cord-277417-f71jwdzj	173	10	also	also	RB
cord-277417-f71jwdzj	173	11	be	be	VB
cord-277417-f71jwdzj	173	12	considered	consider	VBN
cord-277417-f71jwdzj	173	13	an	an	DT
cord-277417-f71jwdzj	173	14	idealized	idealized	JJ
cord-277417-f71jwdzj	173	15	one	one	NN
cord-277417-f71jwdzj	173	16	that	that	WDT
cord-277417-f71jwdzj	173	17	works	work	VBZ
cord-277417-f71jwdzj	173	18	best	well	RBS
cord-277417-f71jwdzj	173	19	when	when	WRB
cord-277417-f71jwdzj	173	20	a	a	DT
cord-277417-f71jwdzj	173	21	limited	limited	JJ
cord-277417-f71jwdzj	173	22	number	number	NN
cord-277417-f71jwdzj	173	23	of	of	IN
cord-277417-f71jwdzj	173	24	genomic	genomic	JJ
cord-277417-f71jwdzj	173	25	mutations	mutation	NNS
cord-277417-f71jwdzj	173	26	act	act	VBP
cord-277417-f71jwdzj	173	27	independently	independently	RB
cord-277417-f71jwdzj	173	28	to	to	TO
cord-277417-f71jwdzj	173	29	shape	shape	VB
cord-277417-f71jwdzj	173	30	virulence	virulence	NN
cord-277417-f71jwdzj	173	31	.	.	.
cord-277417-f71jwdzj	174	1	Virulence	virulence	NN
cord-277417-f71jwdzj	174	2	determinants	determinant	NNS
cord-277417-f71jwdzj	175	1	NATuRE	NATuRE	NNP
cord-277417-f71jwdzj	176	1	REvIEwS	REvIEwS	NNP
cord-277417-f71jwdzj	176	2	|	|	NNP
cord-277417-f71jwdzj	177	1	GEnETiCs	genetics	NN
cord-277417-f71jwdzj	177	2	R	r	NN
cord-277417-f71jwdzj	177	3	e	e	NN
cord-277417-f71jwdzj	178	1	v	v	LS
cord-277417-f71jwdzj	179	1	i	i	PRP
cord-277417-f71jwdzj	180	1	e	e	NNP
cord-277417-f71jwdzj	180	2	w	w	NN
cord-277417-f71jwdzj	180	3	s	s	NNP
cord-277417-f71jwdzj	180	4	voluME	voluME	NNP
cord-277417-f71jwdzj	180	5	19	19	CD
cord-277417-f71jwdzj	180	6	|	|	NNP
cord-277417-f71jwdzj	180	7	DECEMBER	DECEMBER	NNP
cord-277417-f71jwdzj	180	8	2018	2018	CD
cord-277417-f71jwdzj	181	1	|	|	NNP
cord-277417-f71jwdzj	181	2	761	761	CD
cord-277417-f71jwdzj	182	1	The	the	DT
cord-277417-f71jwdzj	182	2	transmission	transmission	NN
cord-277417-f71jwdzj	182	3	of	of	IN
cord-277417-f71jwdzj	182	4	a	a	DT
cord-277417-f71jwdzj	182	5	pathogen	pathogen	NN
cord-277417-f71jwdzj	182	6	from	from	IN
cord-277417-f71jwdzj	182	7	one	one	CD
cord-277417-f71jwdzj	182	8	host	host	NN
cord-277417-f71jwdzj	182	9	species	specie	NNS
cord-277417-f71jwdzj	182	10	to	to	IN
cord-277417-f71jwdzj	182	11	another	another	DT
cord-277417-f71jwdzj	182	12	.	.	.
cord-277417-f71jwdzj	183	1	Also	also	RB
cord-277417-f71jwdzj	183	2	called	call	VBN
cord-277417-f71jwdzj	183	3	hostjumping	hostjumpe	VBG
cord-277417-f71jwdzj	183	4	or	or	CC
cord-277417-f71jwdzj	183	5	host	host	NN
cord-277417-f71jwdzj	183	6	-	-	HYPH
cord-277417-f71jwdzj	183	7	switching	switching	NN
cord-277417-f71jwdzj	183	8	.	.	.
cord-277417-f71jwdzj	184	1	An	an	DT
cord-277417-f71jwdzj	184	2	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	184	3	process	process	NN
cord-277417-f71jwdzj	184	4	by	by	IN
cord-277417-f71jwdzj	184	5	which	which	WDT
cord-277417-f71jwdzj	184	6	two	two	CD
cord-277417-f71jwdzj	184	7	or	or	CC
cord-277417-f71jwdzj	184	8	more	more	JJR
cord-277417-f71jwdzj	184	9	separate	separate	JJ
cord-277417-f71jwdzj	184	10	lineages	lineage	NNS
cord-277417-f71jwdzj	184	11	develop	develop	VBP
cord-277417-f71jwdzj	184	12	identical	identical	JJ
cord-277417-f71jwdzj	184	13	characteristics	characteristic	NNS
cord-277417-f71jwdzj	184	14	independently	independently	RB
cord-277417-f71jwdzj	184	15	.	.	.
cord-277417-f71jwdzj	185	1	The	the	DT
cord-277417-f71jwdzj	185	2	descendants	descendant	NNS
cord-277417-f71jwdzj	185	3	of	of	IN
cord-277417-f71jwdzj	185	4	unrelated	unrelated	JJ
cord-277417-f71jwdzj	185	5	ancestors	ancestor	NNS
cord-277417-f71jwdzj	185	6	that	that	WDT
cord-277417-f71jwdzj	185	7	have	have	VBP
cord-277417-f71jwdzj	185	8	evolved	evolve	VBN
cord-277417-f71jwdzj	185	9	similar	similar	JJ
cord-277417-f71jwdzj	185	10	traits	trait	NNS
cord-277417-f71jwdzj	185	11	independently	independently	RB
cord-277417-f71jwdzj	185	12	.	.	.
cord-277417-f71jwdzj	186	1	Natural	natural	JJ
cord-277417-f71jwdzj	186	2	selection	selection	NN
cord-277417-f71jwdzj	186	3	that	that	WDT
cord-277417-f71jwdzj	186	4	leads	lead	VBZ
cord-277417-f71jwdzj	186	5	to	to	IN
cord-277417-f71jwdzj	186	6	advantageous	advantageous	JJ
cord-277417-f71jwdzj	186	7	mutations	mutation	NNS
cord-277417-f71jwdzj	186	8	spreading	spread	VBG
cord-277417-f71jwdzj	186	9	through	through	IN
cord-277417-f71jwdzj	186	10	a	a	DT
cord-277417-f71jwdzj	186	11	population	population	NN
cord-277417-f71jwdzj	186	12	.	.	.
cord-277417-f71jwdzj	187	1	Mutations	mutation	NNS
cord-277417-f71jwdzj	187	2	in	in	IN
cord-277417-f71jwdzj	187	3	coding	code	VBG
cord-277417-f71jwdzj	187	4	regions	region	NNS
cord-277417-f71jwdzj	187	5	can	can	MD
cord-277417-f71jwdzj	187	6	be	be	VB
cord-277417-f71jwdzj	187	7	either	either	CC
cord-277417-f71jwdzj	187	8	synonymous	synonymous	JJ
cord-277417-f71jwdzj	187	9	(	(	-LRB-
cord-277417-f71jwdzj	187	10	which	which	WDT
cord-277417-f71jwdzj	187	11	do	do	VBP
cord-277417-f71jwdzj	187	12	not	not	RB
cord-277417-f71jwdzj	187	13	change	change	VB
cord-277417-f71jwdzj	187	14	the	the	DT
cord-277417-f71jwdzj	187	15	amino	amino	NN
cord-277417-f71jwdzj	187	16	acid	acid	NN
cord-277417-f71jwdzj	187	17	;	;	:
cord-277417-f71jwdzj	187	18	measured	measure	VBN
cord-277417-f71jwdzj	187	19	as	as	IN
cord-277417-f71jwdzj	187	20	d	d	NNP
cord-277417-f71jwdzj	187	21	S	S	NNP
cord-277417-f71jwdzj	187	22	)	)	-RRB-
cord-277417-f71jwdzj	187	23	or	or	CC
cord-277417-f71jwdzj	187	24	non	non	JJ
cord-277417-f71jwdzj	187	25	-	-	JJ
cord-277417-f71jwdzj	187	26	synonymous	synonymous	JJ
cord-277417-f71jwdzj	187	27	(	(	-LRB-
cord-277417-f71jwdzj	187	28	which	which	WDT
cord-277417-f71jwdzj	187	29	change	change	VBP
cord-277417-f71jwdzj	187	30	the	the	DT
cord-277417-f71jwdzj	187	31	amino	amino	NN
cord-277417-f71jwdzj	187	32	acid	acid	NN
cord-277417-f71jwdzj	187	33	;	;	:
cord-277417-f71jwdzj	187	34	measured	measure	VBN
cord-277417-f71jwdzj	187	35	as	as	IN
cord-277417-f71jwdzj	187	36	d	d	NNP
cord-277417-f71jwdzj	187	37	N	N	NNP
cord-277417-f71jwdzj	187	38	)	)	-RRB-
cord-277417-f71jwdzj	187	39	.	.	.
cord-277417-f71jwdzj	188	1	The	the	DT
cord-277417-f71jwdzj	188	2	d	d	NN
cord-277417-f71jwdzj	188	3	N	N	NNP
cord-277417-f71jwdzj	188	4	/d	/d	NNP
cord-277417-f71jwdzj	188	5	S	S	NNP
cord-277417-f71jwdzj	188	6	ratio	ratio	NN
cord-277417-f71jwdzj	188	7	>	>	XX
cord-277417-f71jwdzj	189	1	1	1	CD
cord-277417-f71jwdzj	189	2	is	be	VBZ
cord-277417-f71jwdzj	189	3	sometimes	sometimes	RB
cord-277417-f71jwdzj	189	4	used	use	VBN
cord-277417-f71jwdzj	189	5	to	to	TO
cord-277417-f71jwdzj	189	6	infer	infer	VB
cord-277417-f71jwdzj	189	7	the	the	DT
cord-277417-f71jwdzj	189	8	occurrence	occurrence	NN
cord-277417-f71jwdzj	189	9	of	of	IN
cord-277417-f71jwdzj	189	10	positive	positive	JJ
cord-277417-f71jwdzj	189	11	selection	selection	NN
cord-277417-f71jwdzj	189	12	,	,	,
cord-277417-f71jwdzj	189	13	although	although	IN
cord-277417-f71jwdzj	189	14	the	the	DT
cord-277417-f71jwdzj	189	15	accuracy	accuracy	NN
cord-277417-f71jwdzj	189	16	of	of	IN
cord-277417-f71jwdzj	189	17	this	this	DT
cord-277417-f71jwdzj	189	18	measure	measure	NN
cord-277417-f71jwdzj	189	19	depends	depend	VBZ
cord-277417-f71jwdzj	189	20	on	on	IN
cord-277417-f71jwdzj	189	21	various	various	JJ
cord-277417-f71jwdzj	189	22	factors	factor	NNS
cord-277417-f71jwdzj	189	23	,	,	,
cord-277417-f71jwdzj	189	24	including	include	VBG
cord-277417-f71jwdzj	189	25	the	the	DT
cord-277417-f71jwdzj	189	26	timescale	timescale	NN
cord-277417-f71jwdzj	189	27	of	of	IN
cord-277417-f71jwdzj	189	28	sampling	sampling	NN
cord-277417-f71jwdzj	189	29	.	.	.
cord-277417-f71jwdzj	190	1	Natural	natural	JJ
cord-277417-f71jwdzj	190	2	selection	selection	NN
cord-277417-f71jwdzj	190	3	that	that	WDT
cord-277417-f71jwdzj	190	4	acts	act	VBZ
cord-277417-f71jwdzj	190	5	to	to	TO
cord-277417-f71jwdzj	190	6	remove	remove	VB
cord-277417-f71jwdzj	190	7	low	low	JJ
cord-277417-f71jwdzj	190	8	-	-	HYPH
cord-277417-f71jwdzj	190	9	fitness	fitness	NN
cord-277417-f71jwdzj	190	10	(	(	-LRB-
cord-277417-f71jwdzj	190	11	including	include	VBG
cord-277417-f71jwdzj	190	12	deleterious	deleterious	JJ
cord-277417-f71jwdzj	190	13	)	)	-RRB-
cord-277417-f71jwdzj	190	14	mutations	mutation	NNS
cord-277417-f71jwdzj	190	15	from	from	IN
cord-277417-f71jwdzj	190	16	populations	population	NNS
cord-277417-f71jwdzj	190	17	.	.	.
cord-277417-f71jwdzj	191	1	It	-PRON-	PRP
cord-277417-f71jwdzj	191	2	is	be	VBZ
cord-277417-f71jwdzj	191	3	the	the	DT
cord-277417-f71jwdzj	191	4	most	most	RBS
cord-277417-f71jwdzj	191	5	common	common	JJ
cord-277417-f71jwdzj	191	6	form	form	NN
cord-277417-f71jwdzj	191	7	of	of	IN
cord-277417-f71jwdzj	191	8	natural	natural	JJ
cord-277417-f71jwdzj	191	9	selection	selection	NN
cord-277417-f71jwdzj	191	10	and	and	CC
cord-277417-f71jwdzj	191	11	gives	give	VBZ
cord-277417-f71jwdzj	191	12	a	a	DT
cord-277417-f71jwdzj	191	13	d	d	NN
cord-277417-f71jwdzj	191	14	N	n	NN
cord-277417-f71jwdzj	191	15	/d	/d	NN
cord-277417-f71jwdzj	191	16	S	s	NN
cord-277417-f71jwdzj	191	17	<	<	XX
cord-277417-f71jwdzj	191	18	1	1	CD
cord-277417-f71jwdzj	191	19	.	.	.
cord-277417-f71jwdzj	192	1	Also	also	RB
cord-277417-f71jwdzj	192	2	called	call	VBN
cord-277417-f71jwdzj	192	3	negative	negative	JJ
cord-277417-f71jwdzj	192	4	selection	selection	NN
cord-277417-f71jwdzj	192	5	.	.	.
cord-277417-f71jwdzj	193	1	may	may	MD
cord-277417-f71jwdzj	193	2	be	be	VB
cord-277417-f71jwdzj	193	3	harder	hard	JJR
cord-277417-f71jwdzj	193	4	to	to	TO
cord-277417-f71jwdzj	193	5	identify	identify	VB
cord-277417-f71jwdzj	193	6	when	when	WRB
cord-277417-f71jwdzj	193	7	there	there	EX
cord-277417-f71jwdzj	193	8	are	be	VBP
cord-277417-f71jwdzj	193	9	more	more	RBR
cord-277417-f71jwdzj	193	10	complex	complex	JJ
cord-277417-f71jwdzj	193	11	interactions	interaction	NNS
cord-277417-f71jwdzj	193	12	between	between	IN
cord-277417-f71jwdzj	193	13	mutations	mutation	NNS
cord-277417-f71jwdzj	193	14	9	9	CD
cord-277417-f71jwdzj	193	15	,	,	,
cord-277417-f71jwdzj	193	16	which	which	WDT
cord-277417-f71jwdzj	193	17	appears	appear	VBZ
cord-277417-f71jwdzj	193	18	to	to	TO
cord-277417-f71jwdzj	193	19	be	be	VB
cord-277417-f71jwdzj	193	20	true	true	JJ
cord-277417-f71jwdzj	193	21	of	of	IN
cord-277417-f71jwdzj	193	22	MYXV	MYXV	NNP
cord-277417-f71jwdzj	193	23	(	(	-LRB-
cord-277417-f71jwdzj	193	24	box	box	NN
cord-277417-f71jwdzj	193	25	2	2	CD
cord-277417-f71jwdzj	193	26	)	)	-RRB-
cord-277417-f71jwdzj	193	27	.	.	.
cord-277417-f71jwdzj	194	1	Although	although	IN
cord-277417-f71jwdzj	194	2	epistasis	epistasis	NN
cord-277417-f71jwdzj	194	3	is	be	VBZ
cord-277417-f71jwdzj	194	4	likely	likely	JJ
cord-277417-f71jwdzj	194	5	to	to	TO
cord-277417-f71jwdzj	194	6	be	be	VB
cord-277417-f71jwdzj	194	7	commonplace	commonplace	JJ
cord-277417-f71jwdzj	194	8	in	in	IN
cord-277417-f71jwdzj	194	9	RNA	RNA	NNP
cord-277417-f71jwdzj	194	10	viruses	virus	NNS
cord-277417-f71jwdzj	194	11	69	69	CD
cord-277417-f71jwdzj	194	12	,	,	,
cord-277417-f71jwdzj	194	13	little	little	JJ
cord-277417-f71jwdzj	194	14	is	be	VBZ
cord-277417-f71jwdzj	194	15	currently	currently	RB
cord-277417-f71jwdzj	194	16	known	know	VBN
cord-277417-f71jwdzj	194	17	about	about	IN
cord-277417-f71jwdzj	194	18	whether	whether	IN
cord-277417-f71jwdzj	194	19	virulence	virulence	NN
cord-277417-f71jwdzj	194	20	mutations	mutation	NNS
cord-277417-f71jwdzj	194	21	interact	interact	VBP
cord-277417-f71jwdzj	194	22	epistatically	epistatically	RB
cord-277417-f71jwdzj	194	23	70	70	CD
cord-277417-f71jwdzj	194	24	.	.	.
cord-277417-f71jwdzj	195	1	Similarly	similarly	RB
cord-277417-f71jwdzj	195	2	,	,	,
cord-277417-f71jwdzj	195	3	this	this	DT
cord-277417-f71jwdzj	195	4	approach	approach	NN
cord-277417-f71jwdzj	195	5	may	may	MD
cord-277417-f71jwdzj	195	6	work	work	VB
cord-277417-f71jwdzj	195	7	best	well	RBS
cord-277417-f71jwdzj	195	8	for	for	IN
cord-277417-f71jwdzj	195	9	RNA	RNA	NNP
cord-277417-f71jwdzj	195	10	viruses	virus	NNS
cord-277417-f71jwdzj	195	11	because	because	IN
cord-277417-f71jwdzj	195	12	their	-PRON-	PRP$
cord-277417-f71jwdzj	195	13	constrained	constrain	VBN
cord-277417-f71jwdzj	195	14	genome	genome	NN
cord-277417-f71jwdzj	195	15	sizes	size	NNS
cord-277417-f71jwdzj	195	16	mean	mean	VBP
cord-277417-f71jwdzj	195	17	that	that	IN
cord-277417-f71jwdzj	195	18	there	there	EX
cord-277417-f71jwdzj	195	19	are	be	VBP
cord-277417-f71jwdzj	195	20	probably	probably	RB
cord-277417-f71jwdzj	195	21	a	a	DT
cord-277417-f71jwdzj	195	22	limited	limited	JJ
cord-277417-f71jwdzj	195	23	number	number	NN
cord-277417-f71jwdzj	195	24	of	of	IN
cord-277417-f71jwdzj	195	25	virulence	virulence	NN
cord-277417-f71jwdzj	195	26	determinants	determinant	NNS
cord-277417-f71jwdzj	195	27	,	,	,
cord-277417-f71jwdzj	195	28	increasing	increase	VBG
cord-277417-f71jwdzj	195	29	the	the	DT
cord-277417-f71jwdzj	195	30	likelihood	likelihood	NN
cord-277417-f71jwdzj	195	31	that	that	IN
cord-277417-f71jwdzj	195	32	they	-PRON-	PRP
cord-277417-f71jwdzj	195	33	are	be	VBP
cord-277417-f71jwdzj	195	34	subject	subject	JJ
cord-277417-f71jwdzj	195	35	to	to	IN
cord-277417-f71jwdzj	195	36	parallel	parallel	JJ
cord-277417-f71jwdzj	195	37	and/or	and/or	CC
cord-277417-f71jwdzj	195	38	convergent	convergent	JJ
cord-277417-f71jwdzj	195	39	evolution	evolution	NN
cord-277417-f71jwdzj	195	40	,	,	,
cord-277417-f71jwdzj	195	41	and	and	CC
cord-277417-f71jwdzj	195	42	rates	rate	NNS
cord-277417-f71jwdzj	195	43	of	of	IN
cord-277417-f71jwdzj	195	44	recombination	recombination	NN
cord-277417-f71jwdzj	195	45	(	(	-LRB-
cord-277417-f71jwdzj	195	46	which	which	WDT
cord-277417-f71jwdzj	195	47	complicate	complicate	VBP
cord-277417-f71jwdzj	195	48	phylogenetic	phylogenetic	JJ
cord-277417-f71jwdzj	195	49	relationships	relationship	NNS
cord-277417-f71jwdzj	195	50	)	)	-RRB-
cord-277417-f71jwdzj	195	51	are	be	VBP
cord-277417-f71jwdzj	195	52	often	often	RB
cord-277417-f71jwdzj	195	53	fairly	fairly	RB
cord-277417-f71jwdzj	195	54	low	low	JJ
cord-277417-f71jwdzj	195	55	within	within	IN
cord-277417-f71jwdzj	195	56	species	species	NN
cord-277417-f71jwdzj	195	57	71	71	CD
cord-277417-f71jwdzj	195	58	.	.	.
cord-277417-f71jwdzj	196	1	To	to	TO
cord-277417-f71jwdzj	196	2	illustrate	illustrate	VB
cord-277417-f71jwdzj	196	3	how	how	WRB
cord-277417-f71jwdzj	196	4	a	a	DT
cord-277417-f71jwdzj	196	5	phylogenomic	phylogenomic	JJ
cord-277417-f71jwdzj	196	6	approach	approach	NN
cord-277417-f71jwdzj	196	7	can	can	MD
cord-277417-f71jwdzj	196	8	shed	shed	VB
cord-277417-f71jwdzj	196	9	light	light	NN
cord-277417-f71jwdzj	196	10	on	on	IN
cord-277417-f71jwdzj	196	11	the	the	DT
cord-277417-f71jwdzj	196	12	evolution	evolution	NN
cord-277417-f71jwdzj	196	13	of	of	IN
cord-277417-f71jwdzj	196	14	virus	virus	NN
cord-277417-f71jwdzj	196	15	virulence	virulence	NN
cord-277417-f71jwdzj	196	16	,	,	,
cord-277417-f71jwdzj	196	17	we	-PRON-	PRP
cord-277417-f71jwdzj	196	18	now	now	RB
cord-277417-f71jwdzj	196	19	briefly	briefly	VBP
cord-277417-f71jwdzj	196	20	outline	outline	VBP
cord-277417-f71jwdzj	196	21	a	a	DT
cord-277417-f71jwdzj	196	22	number	number	NN
cord-277417-f71jwdzj	196	23	of	of	IN
cord-277417-f71jwdzj	196	24	cases	case	NNS
cord-277417-f71jwdzj	196	25	in	in	IN
cord-277417-f71jwdzj	196	26	which	which	WDT
cord-277417-f71jwdzj	196	27	it	-PRON-	PRP
cord-277417-f71jwdzj	196	28	can	can	MD
cord-277417-f71jwdzj	196	29	be	be	VB
cord-277417-f71jwdzj	196	30	or	or	CC
cord-277417-f71jwdzj	196	31	has	have	VBZ
cord-277417-f71jwdzj	196	32	been	be	VBN
cord-277417-f71jwdzj	196	33	applied	apply	VBN
cord-277417-f71jwdzj	196	34	.	.	.
cord-277417-f71jwdzj	197	1	We	-PRON-	PRP
cord-277417-f71jwdzj	197	2	begin	begin	VBP
cord-277417-f71jwdzj	197	3	by	by	IN
cord-277417-f71jwdzj	197	4	considering	consider	VBG
cord-277417-f71jwdzj	197	5	cases	case	NNS
cord-277417-f71jwdzj	197	6	in	in	IN
cord-277417-f71jwdzj	197	7	which	which	WDT
cord-277417-f71jwdzj	197	8	virulence	virulence	NN
cord-277417-f71jwdzj	197	9	determinants	determinant	NNS
cord-277417-f71jwdzj	197	10	have	have	VBP
cord-277417-f71jwdzj	197	11	been	be	VBN
cord-277417-f71jwdzj	197	12	successfully	successfully	RB
cord-277417-f71jwdzj	197	13	mapped	map	VBN
cord-277417-f71jwdzj	197	14	(	(	-LRB-
cord-277417-f71jwdzj	197	15	WNV	WNV	NNP
cord-277417-f71jwdzj	197	16	and	and	CC
cord-277417-f71jwdzj	197	17	avian	avian	JJ
cord-277417-f71jwdzj	197	18	influenza	influenza	NN
cord-277417-f71jwdzj	197	19	A	a	DT
cord-277417-f71jwdzj	197	20	virus	virus	NN
cord-277417-f71jwdzj	197	21	(	(	-LRB-
cord-277417-f71jwdzj	197	22	AIV	AIV	NNP
cord-277417-f71jwdzj	197	23	)	)	-RRB-
cord-277417-f71jwdzj	197	24	)	)	-RRB-
cord-277417-f71jwdzj	197	25	,	,	,
cord-277417-f71jwdzj	197	26	move	move	VB
cord-277417-f71jwdzj	197	27	on	on	RP
cord-277417-f71jwdzj	197	28	to	to	IN
cord-277417-f71jwdzj	197	29	those	those	DT
cord-277417-f71jwdzj	197	30	in	in	IN
cord-277417-f71jwdzj	197	31	which	which	WDT
cord-277417-f71jwdzj	197	32	revealing	reveal	VBG
cord-277417-f71jwdzj	197	33	the	the	DT
cord-277417-f71jwdzj	197	34	mutations	mutation	NNS
cord-277417-f71jwdzj	197	35	that	that	WDT
cord-277417-f71jwdzj	197	36	underpin	underpin	VBP
cord-277417-f71jwdzj	197	37	changes	change	NNS
cord-277417-f71jwdzj	197	38	in	in	IN
cord-277417-f71jwdzj	197	39	virulence	virulence	NN
cord-277417-f71jwdzj	197	40	has	have	VBZ
cord-277417-f71jwdzj	197	41	been	be	VBN
cord-277417-f71jwdzj	197	42	more	more	RBR
cord-277417-f71jwdzj	197	43	complex	complex	JJ
cord-277417-f71jwdzj	197	44	(	(	-LRB-
cord-277417-f71jwdzj	197	45	MYXV	MYXV	NNP
cord-277417-f71jwdzj	197	46	,	,	,
cord-277417-f71jwdzj	197	47	Marek	Marek	NNP
cord-277417-f71jwdzj	197	48	's	's	POS
cord-277417-f71jwdzj	197	49	disease	disease	NN
cord-277417-f71jwdzj	197	50	virus	virus	NN
cord-277417-f71jwdzj	197	51	(	(	-LRB-
cord-277417-f71jwdzj	197	52	MDV	MDV	NNP
cord-277417-f71jwdzj	197	53	)	)	-RRB-
cord-277417-f71jwdzj	197	54	and	and	CC
cord-277417-f71jwdzj	197	55	HIV	HIV	NNP
cord-277417-f71jwdzj	197	56	)	)	-RRB-
cord-277417-f71jwdzj	197	57	and	and	CC
cord-277417-f71jwdzj	197	58	end	end	VB
cord-277417-f71jwdzj	197	59	by	by	IN
cord-277417-f71jwdzj	197	60	examining	examine	VBG
cord-277417-f71jwdzj	197	61	virulence	virulence	NN
cord-277417-f71jwdzj	197	62	evolution	evolution	NN
cord-277417-f71jwdzj	197	63	in	in	IN
cord-277417-f71jwdzj	197	64	two	two	CD
cord-277417-f71jwdzj	197	65	recent	recent	JJ
cord-277417-f71jwdzj	197	66	disease	disease	NN
cord-277417-f71jwdzj	197	67	outbreaks	outbreak	NNS
cord-277417-f71jwdzj	197	68	(	(	-LRB-
cord-277417-f71jwdzj	197	69	EBOV	EBOV	NNP
cord-277417-f71jwdzj	197	70	and	and	CC
cord-277417-f71jwdzj	197	71	ZIKV	ZIKV	NNP
cord-277417-f71jwdzj	197	72	)	)	-RRB-
cord-277417-f71jwdzj	197	73	.	.	.
cord-277417-f71jwdzj	197	74	 	 	_SP
cord-277417-f71jwdzj	198	1	The	the	DT
cord-277417-f71jwdzj	198	2	evolution	evolution	NN
cord-277417-f71jwdzj	198	3	of	of	IN
cord-277417-f71jwdzj	198	4	virulence	virulence	NN
cord-277417-f71jwdzj	198	5	in	in	IN
cord-277417-f71jwdzj	198	6	strains	strain	NNS
cord-277417-f71jwdzj	198	7	of	of	IN
cord-277417-f71jwdzj	198	8	oral	oral	JJ
cord-277417-f71jwdzj	198	9	polio	polio	NN
cord-277417-f71jwdzj	198	10	vaccine	vaccine	NN
cord-277417-f71jwdzj	198	11	(	(	-LRB-
cord-277417-f71jwdzj	198	12	OPV	OPV	NNP
cord-277417-f71jwdzj	198	13	)	)	-RRB-
cord-277417-f71jwdzj	198	14	8	8	CD
cord-277417-f71jwdzj	198	15	.	.	.
cord-277417-f71jwdzj	199	1	OPV	OPV	NNP
cord-277417-f71jwdzj	199	2	is	be	VBZ
cord-277417-f71jwdzj	199	3	an	an	DT
cord-277417-f71jwdzj	199	4	attenuated	attenuated	JJ
cord-277417-f71jwdzj	199	5	form	form	NN
cord-277417-f71jwdzj	199	6	of	of	IN
cord-277417-f71jwdzj	199	7	poliovirus	poliovirus	NN
cord-277417-f71jwdzj	199	8	that	that	WDT
cord-277417-f71jwdzj	199	9	can	can	MD
cord-277417-f71jwdzj	199	10	occasionally	occasionally	RB
cord-277417-f71jwdzj	199	11	revert	revert	VB
cord-277417-f71jwdzj	199	12	to	to	IN
cord-277417-f71jwdzj	199	13	a	a	DT
cord-277417-f71jwdzj	199	14	virulent	virulent	JJ
cord-277417-f71jwdzj	199	15	form	form	NN
cord-277417-f71jwdzj	199	16	and	and	CC
cord-277417-f71jwdzj	199	17	cause	cause	VB
cord-277417-f71jwdzj	199	18	outbreaks	outbreak	NNS
cord-277417-f71jwdzj	199	19	of	of	IN
cord-277417-f71jwdzj	199	20	poliomyelitis	poliomyelitis	NN
cord-277417-f71jwdzj	199	21	.	.	.
cord-277417-f71jwdzj	200	1	A	a	DT
cord-277417-f71jwdzj	200	2	|	|	NNP
cord-277417-f71jwdzj	200	3	Phylogenetic	Phylogenetic	NNP
cord-277417-f71jwdzj	200	4	analysis	analysis	NN
cord-277417-f71jwdzj	200	5	of	of	IN
cord-277417-f71jwdzj	200	6	OPV	OPV	NNP
cord-277417-f71jwdzj	200	7	strains	strain	NNS
cord-277417-f71jwdzj	200	8	in	in	IN
cord-277417-f71jwdzj	200	9	nature	nature	NN
cord-277417-f71jwdzj	200	10	reveals	reveal	VBZ
cord-277417-f71jwdzj	200	11	that	that	IN
cord-277417-f71jwdzj	200	12	some	some	DT
cord-277417-f71jwdzj	200	13	mutations	mutation	NNS
cord-277417-f71jwdzj	200	14	associated	associate	VBN
cord-277417-f71jwdzj	200	15	with	with	IN
cord-277417-f71jwdzj	200	16	high	high	JJ
cord-277417-f71jwdzj	200	17	virulence	virulence	NN
cord-277417-f71jwdzj	200	18	have	have	VBP
cord-277417-f71jwdzj	200	19	experienced	experience	VBN
cord-277417-f71jwdzj	200	20	more	more	RBR
cord-277417-f71jwdzj	200	21	frequent	frequent	JJ
cord-277417-f71jwdzj	200	22	parallel	parallel	JJ
cord-277417-f71jwdzj	200	23	evolution	evolution	NN
cord-277417-f71jwdzj	200	24	than	than	IN
cord-277417-f71jwdzj	200	25	expected	expect	VBN
cord-277417-f71jwdzj	200	26	by	by	IN
cord-277417-f71jwdzj	200	27	chance	chance	NN
cord-277417-f71jwdzj	200	28	(	(	-LRB-
cord-277417-f71jwdzj	200	29	and	and	CC
cord-277417-f71jwdzj	200	30	occupy	occupy	VB
cord-277417-f71jwdzj	200	31	well	well	RB
cord-277417-f71jwdzj	200	32	supported	support	VBN
cord-277417-f71jwdzj	200	33	nodes	node	NNS
cord-277417-f71jwdzj	200	34	)	)	-RRB-
cord-277417-f71jwdzj	200	35	and	and	CC
cord-277417-f71jwdzj	200	36	hence	hence	RB
cord-277417-f71jwdzj	200	37	are	be	VBP
cord-277417-f71jwdzj	200	38	likely	likely	JJ
cord-277417-f71jwdzj	200	39	to	to	TO
cord-277417-f71jwdzj	200	40	be	be	VB
cord-277417-f71jwdzj	200	41	seletively	seletively	RB
cord-277417-f71jwdzj	200	42	favoured	favour	VBN
cord-277417-f71jwdzj	200	43	8	8	CD
cord-277417-f71jwdzj	200	44	.	.	.
cord-277417-f71jwdzj	201	1	B	b	NN
cord-277417-f71jwdzj	201	2	|	|	CD
cord-277417-f71jwdzj	202	1	Computational	computational	JJ
cord-277417-f71jwdzj	202	2	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	202	3	analysis	analysis	NN
cord-277417-f71jwdzj	202	4	then	then	RB
cord-277417-f71jwdzj	202	5	reveals	reveal	VBZ
cord-277417-f71jwdzj	202	6	that	that	IN
cord-277417-f71jwdzj	202	7	this	this	DT
cord-277417-f71jwdzj	202	8	parallel	parallel	JJ
cord-277417-f71jwdzj	202	9	evolution	evolution	NN
cord-277417-f71jwdzj	202	10	for	for	IN
cord-277417-f71jwdzj	202	11	high	high	JJ
cord-277417-f71jwdzj	202	12	virulence	virulence	NN
cord-277417-f71jwdzj	202	13	is	be	VBZ
cord-277417-f71jwdzj	202	14	associated	associate	VBN
cord-277417-f71jwdzj	202	15	with	with	IN
cord-277417-f71jwdzj	202	16	a	a	DT
cord-277417-f71jwdzj	202	17	hypothetical	hypothetical	JJ
cord-277417-f71jwdzj	202	18	threonine	threonine	NN
cord-277417-f71jwdzj	202	19	-	-	HYPH
cord-277417-f71jwdzj	202	20	to	to	IN
cord-277417-f71jwdzj	202	21	-	-	HYPH
cord-277417-f71jwdzj	202	22	proline	proline	NN
cord-277417-f71jwdzj	202	23	(	(	-LRB-
cord-277417-f71jwdzj	202	24	T	t	NN
cord-277417-f71jwdzj	202	25	-	-	HYPH
cord-277417-f71jwdzj	202	26	to	to	IN
cord-277417-f71jwdzj	202	27	-	-	HYPH
cord-277417-f71jwdzj	202	28	P	p	NN
cord-277417-f71jwdzj	202	29	)	)	-RRB-
cord-277417-f71jwdzj	202	30	amino	amino	NN
cord-277417-f71jwdzj	202	31	acid	acid	NN
cord-277417-f71jwdzj	202	32	change	change	NN
cord-277417-f71jwdzj	202	33	that	that	WDT
cord-277417-f71jwdzj	202	34	is	be	VBZ
cord-277417-f71jwdzj	202	35	subject	subject	JJ
cord-277417-f71jwdzj	202	36	to	to	IN
cord-277417-f71jwdzj	202	37	significant	significant	JJ
cord-277417-f71jwdzj	202	38	adaptive	adaptive	JJ
cord-277417-f71jwdzj	202	39	evolution	evolution	NN
cord-277417-f71jwdzj	202	40	(	(	-LRB-
cord-277417-f71jwdzj	202	41	which	which	WDT
cord-277417-f71jwdzj	202	42	can	can	MD
cord-277417-f71jwdzj	202	43	be	be	VB
cord-277417-f71jwdzj	202	44	detected	detect	VBN
cord-277417-f71jwdzj	202	45	in	in	IN
cord-277417-f71jwdzj	202	46	a	a	DT
cord-277417-f71jwdzj	202	47	variety	variety	NN
cord-277417-f71jwdzj	202	48	of	of	IN
cord-277417-f71jwdzj	202	49	ways	way	NNS
cord-277417-f71jwdzj	202	50	)	)	-RRB-
cord-277417-f71jwdzj	202	51	60	60	CD
cord-277417-f71jwdzj	202	52	,	,	,
cord-277417-f71jwdzj	202	53	63	63	CD
cord-277417-f71jwdzj	202	54	.	.	.
cord-277417-f71jwdzj	203	1	C	C	NNP
cord-277417-f71jwdzj	203	2	|	|	NNP
cord-277417-f71jwdzj	204	1	The	the	DT
cord-277417-f71jwdzj	204	2	virulence	virulence	NN
cord-277417-f71jwdzj	204	3	impact	impact	NN
cord-277417-f71jwdzj	204	4	of	of	IN
cord-277417-f71jwdzj	204	5	these	these	DT
cord-277417-f71jwdzj	204	6	mutations	mutation	NNS
cord-277417-f71jwdzj	204	7	is	be	VBZ
cord-277417-f71jwdzj	204	8	then	then	RB
cord-277417-f71jwdzj	204	9	confirmed	confirm	VBN
cord-277417-f71jwdzj	204	10	in	in	IN
cord-277417-f71jwdzj	204	11	both	both	DT
cord-277417-f71jwdzj	204	12	in	in	IN
cord-277417-f71jwdzj	204	13	vitro	vitro	FW
cord-277417-f71jwdzj	204	14	(	(	-LRB-
cord-277417-f71jwdzj	204	15	cell	cell	NN
cord-277417-f71jwdzj	204	16	culture	culture	NN
cord-277417-f71jwdzj	204	17	;	;	:
cord-277417-f71jwdzj	204	18	part	part	NN
cord-277417-f71jwdzj	204	19	Ca	Ca	NNP
cord-277417-f71jwdzj	204	20	)	)	-RRB-
cord-277417-f71jwdzj	204	21	and	and	CC
cord-277417-f71jwdzj	204	22	in	in	IN
cord-277417-f71jwdzj	204	23	vivo	vivo	NNP
cord-277417-f71jwdzj	204	24	(	(	-LRB-
cord-277417-f71jwdzj	204	25	mouse	mouse	NN
cord-277417-f71jwdzj	204	26	;	;	:
cord-277417-f71jwdzj	204	27	part	part	NN
cord-277417-f71jwdzj	204	28	Cb	Cb	NNP
cord-277417-f71jwdzj	204	29	)	)	-RRB-
cord-277417-f71jwdzj	204	30	experimental	experimental	JJ
cord-277417-f71jwdzj	204	31	studies	study	NNS
cord-277417-f71jwdzj	204	32	.	.	.
cord-277417-f71jwdzj	205	1	In	in	IN
cord-277417-f71jwdzj	205	2	all	all	DT
cord-277417-f71jwdzj	205	3	cases	case	NNS
cord-277417-f71jwdzj	205	4	,	,	,
cord-277417-f71jwdzj	205	5	the	the	DT
cord-277417-f71jwdzj	205	6	red	red	JJ
cord-277417-f71jwdzj	205	7	shading	shading	NN
cord-277417-f71jwdzj	205	8	signifies	signify	VBZ
cord-277417-f71jwdzj	205	9	increased	increase	VBN
cord-277417-f71jwdzj	205	10	virulence	virulence	NN
cord-277417-f71jwdzj	205	11	.	.	.
cord-277417-f71jwdzj	206	1	The	the	DT
cord-277417-f71jwdzj	206	2	interaction	interaction	NN
cord-277417-f71jwdzj	206	3	among	among	IN
cord-277417-f71jwdzj	206	4	genes	gene	NNS
cord-277417-f71jwdzj	206	5	at	at	IN
cord-277417-f71jwdzj	206	6	different	different	JJ
cord-277417-f71jwdzj	206	7	loci	locus	NNS
cord-277417-f71jwdzj	206	8	.	.	.
cord-277417-f71jwdzj	207	1	The	the	DT
cord-277417-f71jwdzj	207	2	function	function	NN
cord-277417-f71jwdzj	207	3	and	and	CC
cord-277417-f71jwdzj	207	4	evolution	evolution	NN
cord-277417-f71jwdzj	207	5	of	of	IN
cord-277417-f71jwdzj	207	6	one	one	CD
cord-277417-f71jwdzj	207	7	gene	gene	NN
cord-277417-f71jwdzj	207	8	may	may	MD
cord-277417-f71jwdzj	207	9	be	be	VB
cord-277417-f71jwdzj	207	10	dependent	dependent	JJ
cord-277417-f71jwdzj	207	11	on	on	IN
cord-277417-f71jwdzj	207	12	the	the	DT
cord-277417-f71jwdzj	207	13	presence	presence	NN
cord-277417-f71jwdzj	207	14	of	of	IN
cord-277417-f71jwdzj	207	15	one	one	CD
cord-277417-f71jwdzj	207	16	or	or	CC
cord-277417-f71jwdzj	207	17	more	more	JJR
cord-277417-f71jwdzj	207	18	other	other	JJ
cord-277417-f71jwdzj	207	19	genes	gene	NNS
cord-277417-f71jwdzj	207	20	.	.	.
cord-277417-f71jwdzj	208	1	analysis	analysis	NN
cord-277417-f71jwdzj	208	2	in	in	IN
cord-277417-f71jwdzj	208	3	each	each	DT
cord-277417-f71jwdzj	208	4	case	case	NN
cord-277417-f71jwdzj	208	5	has	have	VBZ
cord-277417-f71jwdzj	208	6	told	tell	VBN
cord-277417-f71jwdzj	208	7	us	-PRON-	PRP
cord-277417-f71jwdzj	208	8	about	about	IN
cord-277417-f71jwdzj	208	9	the	the	DT
cord-277417-f71jwdzj	208	10	evolution	evolution	NN
cord-277417-f71jwdzj	208	11	of	of	IN
cord-277417-f71jwdzj	208	12	virulence	virulence	NN
cord-277417-f71jwdzj	208	13	in	in	IN
cord-277417-f71jwdzj	208	14	general	general	JJ
cord-277417-f71jwdzj	208	15	.	.	.
cord-277417-f71jwdzj	209	1	In	in	IN
cord-277417-f71jwdzj	209	2	1999	1999	CD
cord-277417-f71jwdzj	209	3	,	,	,
cord-277417-f71jwdzj	209	4	a	a	DT
cord-277417-f71jwdzj	209	5	new	new	JJ
cord-277417-f71jwdzj	209	6	lineage	lineage	NN
cord-277417-f71jwdzj	209	7	of	of	IN
cord-277417-f71jwdzj	209	8	WNV	WNV	NNP
cord-277417-f71jwdzj	209	9	became	become	VBD
cord-277417-f71jwdzj	209	10	the	the	DT
cord-277417-f71jwdzj	209	11	leading	leading	JJ
cord-277417-f71jwdzj	209	12	cause	cause	NN
cord-277417-f71jwdzj	209	13	of	of	IN
cord-277417-f71jwdzj	209	14	arthropod	arthropod	NN
cord-277417-f71jwdzj	209	15	-	-	HYPH
cord-277417-f71jwdzj	209	16	borne	bear	VBN
cord-277417-f71jwdzj	209	17	viral	viral	JJ
cord-277417-f71jwdzj	209	18	encephalitis	encephalitis	RB
cord-277417-f71jwdzj	209	19	in	in	IN
cord-277417-f71jwdzj	209	20	humans	human	NNS
cord-277417-f71jwdzj	209	21	and	and	CC
cord-277417-f71jwdzj	209	22	horses	horse	NNS
cord-277417-f71jwdzj	209	23	in	in	IN
cord-277417-f71jwdzj	209	24	North	North	NNP
cord-277417-f71jwdzj	209	25	America	America	NNP
cord-277417-f71jwdzj	209	26	,	,	,
cord-277417-f71jwdzj	209	27	spreading	spread	VBG
cord-277417-f71jwdzj	209	28	from	from	IN
cord-277417-f71jwdzj	209	29	east	east	NN
cord-277417-f71jwdzj	209	30	to	to	IN
cord-277417-f71jwdzj	209	31	west	west	NN
cord-277417-f71jwdzj	209	32	across	across	IN
cord-277417-f71jwdzj	209	33	the	the	DT
cord-277417-f71jwdzj	209	34	continent	continent	NN
cord-277417-f71jwdzj	209	35	72	72	CD
cord-277417-f71jwdzj	209	36	and	and	CC
cord-277417-f71jwdzj	209	37	causing	cause	VBG
cord-277417-f71jwdzj	209	38	severe	severe	JJ
cord-277417-f71jwdzj	209	39	mortality	mortality	NN
cord-277417-f71jwdzj	209	40	in	in	IN
cord-277417-f71jwdzj	209	41	many	many	JJ
cord-277417-f71jwdzj	209	42	bird	bird	NN
cord-277417-f71jwdzj	209	43	species	specie	NNS
cord-277417-f71jwdzj	209	44	,	,	,
cord-277417-f71jwdzj	209	45	particularly	particularly	RB
cord-277417-f71jwdzj	209	46	the	the	DT
cord-277417-f71jwdzj	209	47	American	american	JJ
cord-277417-f71jwdzj	209	48	crow	crow	NN
cord-277417-f71jwdzj	209	49	73	73	CD
cord-277417-f71jwdzj	209	50	.	.	.
cord-277417-f71jwdzj	210	1	Phylogenomic	Phylogenomic	NNP
cord-277417-f71jwdzj	210	2	analysis	analysis	NN
cord-277417-f71jwdzj	210	3	revealed	reveal	VBD
cord-277417-f71jwdzj	210	4	that	that	IN
cord-277417-f71jwdzj	210	5	a	a	DT
cord-277417-f71jwdzj	210	6	single	single	JJ
cord-277417-f71jwdzj	210	7	Thr249Pro	thr249pro	NN
cord-277417-f71jwdzj	210	8	(	(	-LRB-
cord-277417-f71jwdzj	210	9	T249P	t249p	NN
cord-277417-f71jwdzj	210	10	)	)	-RRB-
cord-277417-f71jwdzj	210	11	amino	amino	NN
cord-277417-f71jwdzj	210	12	acid	acid	NN
cord-277417-f71jwdzj	210	13	substitution	substitution	NN
cord-277417-f71jwdzj	210	14	in	in	IN
cord-277417-f71jwdzj	210	15	the	the	DT
cord-277417-f71jwdzj	210	16	virus	virus	NN
cord-277417-f71jwdzj	211	1	NS3	ns3	RB
cord-277417-f71jwdzj	211	2	helicase	helicase	NNP
cord-277417-f71jwdzj	211	3	protein	protein	NN
cord-277417-f71jwdzj	211	4	was	be	VBD
cord-277417-f71jwdzj	211	5	associated	associate	VBN
cord-277417-f71jwdzj	211	6	with	with	IN
cord-277417-f71jwdzj	211	7	high	high	JJ
cord-277417-f71jwdzj	211	8	-	-	HYPH
cord-277417-f71jwdzj	211	9	virulence	virulence	NN
cord-277417-f71jwdzj	211	10	WNV	WNV	NNP
cord-277417-f71jwdzj	211	11	outbreaks	outbreak	NNS
cord-277417-f71jwdzj	211	12	in	in	IN
cord-277417-f71jwdzj	211	13	corvids	corvid	NNS
cord-277417-f71jwdzj	211	14	on	on	IN
cord-277417-f71jwdzj	211	15	multiple	multiple	JJ
cord-277417-f71jwdzj	211	16	continents	continent	NNS
cord-277417-f71jwdzj	211	17	.	.	.
cord-277417-f71jwdzj	212	1	Experimental	experimental	JJ
cord-277417-f71jwdzj	212	2	analysis	analysis	NN
cord-277417-f71jwdzj	212	3	in	in	IN
cord-277417-f71jwdzj	212	4	captive	captive	JJ
cord-277417-f71jwdzj	212	5	crows	crow	NNS
cord-277417-f71jwdzj	212	6	then	then	RB
cord-277417-f71jwdzj	212	7	showed	show	VBD
cord-277417-f71jwdzj	212	8	that	that	IN
cord-277417-f71jwdzj	212	9	this	this	DT
cord-277417-f71jwdzj	212	10	mutation	mutation	NN
cord-277417-f71jwdzj	212	11	was	be	VBD
cord-277417-f71jwdzj	212	12	sufficient	sufficient	JJ
cord-277417-f71jwdzj	212	13	to	to	TO
cord-277417-f71jwdzj	212	14	explain	explain	VB
cord-277417-f71jwdzj	212	15	the	the	DT
cord-277417-f71jwdzj	212	16	high	high	JJ
cord-277417-f71jwdzj	212	17	fatality	fatality	NN
cord-277417-f71jwdzj	212	18	rates	rate	NNS
cord-277417-f71jwdzj	212	19	in	in	IN
cord-277417-f71jwdzj	212	20	American	american	JJ
cord-277417-f71jwdzj	212	21	crows	crow	NNS
cord-277417-f71jwdzj	212	22	,	,	,
cord-277417-f71jwdzj	212	23	perhaps	perhaps	RB
cord-277417-f71jwdzj	212	24	because	because	IN
cord-277417-f71jwdzj	212	25	it	-PRON-	PRP
cord-277417-f71jwdzj	212	26	increased	increase	VBD
cord-277417-f71jwdzj	212	27	the	the	DT
cord-277417-f71jwdzj	212	28	rate	rate	NN
cord-277417-f71jwdzj	212	29	of	of	IN
cord-277417-f71jwdzj	212	30	virus	virus	NN
cord-277417-f71jwdzj	212	31	replication	replication	NN
cord-277417-f71jwdzj	212	32	58	58	CD
cord-277417-f71jwdzj	212	33	.	.	.
cord-277417-f71jwdzj	213	1	WNV	WNV	NNP
cord-277417-f71jwdzj	213	2	therefore	therefore	RB
cord-277417-f71jwdzj	213	3	provides	provide	VBZ
cord-277417-f71jwdzj	213	4	an	an	DT
cord-277417-f71jwdzj	213	5	important	important	JJ
cord-277417-f71jwdzj	213	6	example	example	NN
cord-277417-f71jwdzj	213	7	of	of	IN
cord-277417-f71jwdzj	213	8	where	where	WRB
cord-277417-f71jwdzj	213	9	a	a	DT
cord-277417-f71jwdzj	213	10	single	single	JJ
cord-277417-f71jwdzj	213	11	genetic	genetic	JJ
cord-277417-f71jwdzj	213	12	switch	switch	NN
cord-277417-f71jwdzj	213	13	controls	control	NNS
cord-277417-f71jwdzj	213	14	virulence	virulence	NN
cord-277417-f71jwdzj	213	15	,	,	,
cord-277417-f71jwdzj	213	16	which	which	WDT
cord-277417-f71jwdzj	213	17	is	be	VBZ
cord-277417-f71jwdzj	213	18	obviously	obviously	RB
cord-277417-f71jwdzj	213	19	the	the	DT
cord-277417-f71jwdzj	213	20	easiest	easy	JJS
cord-277417-f71jwdzj	213	21	scenario	scenario	NN
cord-277417-f71jwdzj	213	22	to	to	TO
cord-277417-f71jwdzj	213	23	detect	detect	VB
cord-277417-f71jwdzj	213	24	using	use	VBG
cord-277417-f71jwdzj	213	25	a	a	DT
cord-277417-f71jwdzj	213	26	phylogenomic	phylogenomic	JJ
cord-277417-f71jwdzj	213	27	approach	approach	NN
cord-277417-f71jwdzj	213	28	.	.	.
cord-277417-f71jwdzj	214	1	Of	of	IN
cord-277417-f71jwdzj	214	2	more	more	JJR
cord-277417-f71jwdzj	214	3	general	general	JJ
cord-277417-f71jwdzj	214	4	importance	importance	NN
cord-277417-f71jwdzj	214	5	was	be	VBD
cord-277417-f71jwdzj	214	6	that	that	IN
cord-277417-f71jwdzj	214	7	T249P	T249P	NNP
cord-277417-f71jwdzj	214	8	evolved	evolve	VBN
cord-277417-f71jwdzj	214	9	in	in	IN
cord-277417-f71jwdzj	214	10	parallel	parallel	NN
cord-277417-f71jwdzj	214	11	and	and	CC
cord-277417-f71jwdzj	214	12	experienced	experience	VBD
cord-277417-f71jwdzj	214	13	an	an	DT
cord-277417-f71jwdzj	214	14	elevated	elevated	JJ
cord-277417-f71jwdzj	214	15	rate	rate	NN
cord-277417-f71jwdzj	214	16	of	of	IN
cord-277417-f71jwdzj	214	17	nonsynonymous	nonsynonymous	JJ
cord-277417-f71jwdzj	214	18	change	change	NN
cord-277417-f71jwdzj	214	19	,	,	,
cord-277417-f71jwdzj	214	20	suggesting	suggest	VBG
cord-277417-f71jwdzj	214	21	that	that	IN
cord-277417-f71jwdzj	214	22	high	high	JJ
cord-277417-f71jwdzj	214	23	virulence	virulence	NN
cord-277417-f71jwdzj	214	24	was	be	VBD
cord-277417-f71jwdzj	214	25	selectively	selectively	RB
cord-277417-f71jwdzj	214	26	favoured	favour	VBN
cord-277417-f71jwdzj	214	27	in	in	IN
cord-277417-f71jwdzj	214	28	the	the	DT
cord-277417-f71jwdzj	214	29	absence	absence	NN
cord-277417-f71jwdzj	214	30	of	of	IN
cord-277417-f71jwdzj	214	31	an	an	DT
cord-277417-f71jwdzj	214	32	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	214	33	trade	trade	NN
cord-277417-f71jwdzj	214	34	-	-	HYPH
cord-277417-f71jwdzj	214	35	off	off	NN
cord-277417-f71jwdzj	214	36	as	as	IN
cord-277417-f71jwdzj	214	37	no	no	DT
cord-277417-f71jwdzj	214	38	reciprocal	reciprocal	JJ
cord-277417-f71jwdzj	214	39	mutations	mutation	NNS
cord-277417-f71jwdzj	214	40	were	be	VBD
cord-277417-f71jwdzj	214	41	observed	observe	VBN
cord-277417-f71jwdzj	214	42	elsewhere	elsewhere	RB
cord-277417-f71jwdzj	214	43	in	in	IN
cord-277417-f71jwdzj	214	44	the	the	DT
cord-277417-f71jwdzj	214	45	viral	viral	JJ
cord-277417-f71jwdzj	214	46	genome	genome	NN
cord-277417-f71jwdzj	214	47	58	58	CD
cord-277417-f71jwdzj	214	48	 	 	_SP
cord-277417-f71jwdzj	215	1	The	the	DT
cord-277417-f71jwdzj	215	2	co	co	NN
cord-277417-f71jwdzj	215	3	-	-	NN
cord-277417-f71jwdzj	215	4	evolution	evolution	NN
cord-277417-f71jwdzj	215	5	of	of	IN
cord-277417-f71jwdzj	215	6	European	european	JJ
cord-277417-f71jwdzj	215	7	rabbits	rabbit	NNS
cord-277417-f71jwdzj	215	8	(	(	-LRB-
cord-277417-f71jwdzj	215	9	Oryctolagus	Oryctolagus	NNP
cord-277417-f71jwdzj	215	10	cuniculus	cuniculus	NN
cord-277417-f71jwdzj	215	11	)	)	-RRB-
cord-277417-f71jwdzj	215	12	and	and	CC
cord-277417-f71jwdzj	215	13	the	the	DT
cord-277417-f71jwdzj	215	14	myxoma	myxoma	NNP
cord-277417-f71jwdzj	215	15	virus	virus	NN
cord-277417-f71jwdzj	215	16	(	(	-LRB-
cord-277417-f71jwdzj	215	17	MYXv	MYXv	NNS
cord-277417-f71jwdzj	215	18	)	)	-RRB-
cord-277417-f71jwdzj	215	19	released	release	VBN
cord-277417-f71jwdzj	215	20	as	as	IN
cord-277417-f71jwdzj	215	21	a	a	DT
cord-277417-f71jwdzj	215	22	biological	biological	JJ
cord-277417-f71jwdzj	215	23	control	control	NN
cord-277417-f71jwdzj	215	24	against	against	IN
cord-277417-f71jwdzj	215	25	them	-PRON-	PRP
cord-277417-f71jwdzj	215	26	is	be	VBZ
cord-277417-f71jwdzj	215	27	arguably	arguably	RB
cord-277417-f71jwdzj	215	28	the	the	DT
cord-277417-f71jwdzj	215	29	most	most	RBS
cord-277417-f71jwdzj	215	30	famous	famous	JJ
cord-277417-f71jwdzj	215	31	case	case	NN
cord-277417-f71jwdzj	215	32	study	study	NN
cord-277417-f71jwdzj	215	33	in	in	IN
cord-277417-f71jwdzj	215	34	virulence	virulence	NN
cord-277417-f71jwdzj	215	35	evolution	evolution	NN
cord-277417-f71jwdzj	215	36	.	.	.
cord-277417-f71jwdzj	216	1	Fenner	Fenner	NNP
cord-277417-f71jwdzj	216	2	and	and	CC
cord-277417-f71jwdzj	216	3	colleagues	colleague	NNS
cord-277417-f71jwdzj	216	4	93	93	CD
cord-277417-f71jwdzj	216	5	were	be	VBD
cord-277417-f71jwdzj	216	6	able	able	JJ
cord-277417-f71jwdzj	216	7	to	to	TO
cord-277417-f71jwdzj	216	8	identify	identify	VB
cord-277417-f71jwdzj	216	9	'	'	``
cord-277417-f71jwdzj	216	10	grades	grade	NNS
cord-277417-f71jwdzj	216	11	'	'	POS
cord-277417-f71jwdzj	216	12	of	of	IN
cord-277417-f71jwdzj	216	13	MYXv	MYXv	NNS
cord-277417-f71jwdzj	216	14	virulence	virulence	NN
cord-277417-f71jwdzj	216	15	using	use	VBG
cord-277417-f71jwdzj	216	16	laboratory	laboratory	NN
cord-277417-f71jwdzj	216	17	assays	assay	NNS
cord-277417-f71jwdzj	216	18	in	in	IN
cord-277417-f71jwdzj	216	19	European	european	JJ
cord-277417-f71jwdzj	216	20	rabbits	rabbit	NNS
cord-277417-f71jwdzj	216	21	.	.	.
cord-277417-f71jwdzj	217	1	The	the	DT
cord-277417-f71jwdzj	217	2	most	most	RBS
cord-277417-f71jwdzj	217	3	lethal	lethal	JJ
cord-277417-f71jwdzj	217	4	grade	grade	NN
cord-277417-f71jwdzj	217	5	I	-PRON-	PRP
cord-277417-f71jwdzj	217	6	strains	strain	VBZ
cord-277417-f71jwdzj	217	7	(	(	-LRB-
cord-277417-f71jwdzj	217	8	shaded	shade	VBN
cord-277417-f71jwdzj	217	9	red	red	NN
cord-277417-f71jwdzj	217	10	in	in	IN
cord-277417-f71jwdzj	217	11	the	the	DT
cord-277417-f71jwdzj	217	12	figure	figure	NN
cord-277417-f71jwdzj	217	13	)	)	-RRB-
cord-277417-f71jwdzj	217	14	were	be	VBD
cord-277417-f71jwdzj	217	15	characterized	characterize	VBN
cord-277417-f71jwdzj	217	16	by	by	IN
cord-277417-f71jwdzj	217	17	almost	almost	RB
cord-277417-f71jwdzj	217	18	100	100	CD
cord-277417-f71jwdzj	217	19	%	%	NN
cord-277417-f71jwdzj	217	20	mortality	mortality	NN
cord-277417-f71jwdzj	217	21	,	,	,
cord-277417-f71jwdzj	217	22	whereas	whereas	IN
cord-277417-f71jwdzj	217	23	the	the	DT
cord-277417-f71jwdzj	217	24	most	most	RBS
cord-277417-f71jwdzj	217	25	'	'	``
cord-277417-f71jwdzj	217	26	attenuated	attenuated	JJ
cord-277417-f71jwdzj	217	27	'	'	''
cord-277417-f71jwdzj	217	28	grade	grade	NN
cord-277417-f71jwdzj	217	29	v	v	IN
cord-277417-f71jwdzj	217	30	strains	strain	NNS
cord-277417-f71jwdzj	217	31	had	have	VBD
cord-277417-f71jwdzj	217	32	mortality	mortality	NN
cord-277417-f71jwdzj	217	33	<	<	XX
cord-277417-f71jwdzj	217	34	50	50	CD
cord-277417-f71jwdzj	217	35	%	%	NN
cord-277417-f71jwdzj	217	36	and	and	CC
cord-277417-f71jwdzj	217	37	longer	long	JJR
cord-277417-f71jwdzj	217	38	survival	survival	NN
cord-277417-f71jwdzj	217	39	times	time	NNS
cord-277417-f71jwdzj	217	40	.	.	.
cord-277417-f71jwdzj	218	1	Grade	grade	NN
cord-277417-f71jwdzj	218	2	I	-PRON-	PRP
cord-277417-f71jwdzj	218	3	strains	strain	NNS
cord-277417-f71jwdzj	218	4	were	be	VBD
cord-277417-f71jwdzj	218	5	released	release	VBN
cord-277417-f71jwdzj	218	6	in	in	IN
cord-277417-f71jwdzj	218	7	both	both	DT
cord-277417-f71jwdzj	218	8	Australia	Australia	NNP
cord-277417-f71jwdzj	218	9	(	(	-LRB-
cord-277417-f71jwdzj	218	10	starting	starting	NN
cord-277417-f71jwdzj	218	11	strain	strain	NN
cord-277417-f71jwdzj	218	12	,	,	,
cord-277417-f71jwdzj	218	13	SlS	SlS	NNP
cord-277417-f71jwdzj	218	14	)	)	-RRB-
cord-277417-f71jwdzj	218	15	and	and	CC
cord-277417-f71jwdzj	218	16	Europe	Europe	NNP
cord-277417-f71jwdzj	218	17	(	(	-LRB-
cord-277417-f71jwdzj	218	18	starting	start	VBG
cord-277417-f71jwdzj	218	19	strain	strain	NN
cord-277417-f71jwdzj	218	20	,	,	,
cord-277417-f71jwdzj	218	21	lausanne	lausanne	NNP
cord-277417-f71jwdzj	218	22	)	)	-RRB-
cord-277417-f71jwdzj	218	23	in	in	IN
cord-277417-f71jwdzj	218	24	the	the	DT
cord-277417-f71jwdzj	218	25	early	early	JJ
cord-277417-f71jwdzj	218	26	1950s	1950	NNS
cord-277417-f71jwdzj	218	27	,	,	,
cord-277417-f71jwdzj	218	28	and	and	CC
cord-277417-f71jwdzj	218	29	soon	soon	RB
cord-277417-f71jwdzj	218	30	after	after	IN
cord-277417-f71jwdzj	218	31	lower	low	JJR
cord-277417-f71jwdzj	218	32	virulence	virulence	NN
cord-277417-f71jwdzj	218	33	viruses	virus	NNS
cord-277417-f71jwdzj	218	34	began	begin	VBD
cord-277417-f71jwdzj	218	35	to	to	TO
cord-277417-f71jwdzj	218	36	appear	appear	VB
cord-277417-f71jwdzj	218	37	in	in	IN
cord-277417-f71jwdzj	218	38	parallel	parallel	NN
cord-277417-f71jwdzj	218	39	in	in	IN
cord-277417-f71jwdzj	218	40	both	both	DT
cord-277417-f71jwdzj	218	41	continents	continent	NNS
cord-277417-f71jwdzj	218	42	,	,	,
cord-277417-f71jwdzj	218	43	with	with	IN
cord-277417-f71jwdzj	218	44	intermediate	intermediate	JJ
cord-277417-f71jwdzj	218	45	virulence	virulence	NN
cord-277417-f71jwdzj	218	46	grades	grade	NNS
cord-277417-f71jwdzj	218	47	(	(	-LRB-
cord-277417-f71jwdzj	218	48	for	for	IN
cord-277417-f71jwdzj	218	49	example	example	NN
cord-277417-f71jwdzj	218	50	,	,	,
cord-277417-f71jwdzj	218	51	grade	grade	NN
cord-277417-f71jwdzj	218	52	III	III	NNP
cord-277417-f71jwdzj	218	53	)	)	-RRB-
cord-277417-f71jwdzj	218	54	becoming	become	VBG
cord-277417-f71jwdzj	218	55	the	the	DT
cord-277417-f71jwdzj	218	56	most	most	RBS
cord-277417-f71jwdzj	218	57	common	common	JJ
cord-277417-f71jwdzj	218	58	in	in	IN
cord-277417-f71jwdzj	218	59	the	the	DT
cord-277417-f71jwdzj	218	60	field	field	NN
cord-277417-f71jwdzj	218	61	.	.	.
cord-277417-f71jwdzj	219	1	Although	although	IN
cord-277417-f71jwdzj	219	2	of	of	IN
cord-277417-f71jwdzj	219	3	large	large	JJ
cord-277417-f71jwdzj	219	4	importance	importance	NN
cord-277417-f71jwdzj	219	5	,	,	,
cord-277417-f71jwdzj	219	6	the	the	DT
cord-277417-f71jwdzj	219	7	studies	study	NNS
cord-277417-f71jwdzj	219	8	of	of	IN
cord-277417-f71jwdzj	219	9	Fenner	Fenner	NNP
cord-277417-f71jwdzj	219	10	were	be	VBD
cord-277417-f71jwdzj	219	11	necessarily	necessarily	RB
cord-277417-f71jwdzj	219	12	limited	limit	VBN
cord-277417-f71jwdzj	219	13	in	in	IN
cord-277417-f71jwdzj	219	14	that	that	IN
cord-277417-f71jwdzj	219	15	the	the	DT
cord-277417-f71jwdzj	219	16	genetic	genetic	JJ
cord-277417-f71jwdzj	219	17	basis	basis	NN
cord-277417-f71jwdzj	219	18	of	of	IN
cord-277417-f71jwdzj	219	19	virulence	virulence	NN
cord-277417-f71jwdzj	219	20	evolution	evolution	NN
cord-277417-f71jwdzj	219	21	was	be	VBD
cord-277417-f71jwdzj	219	22	unknown	unknown	JJ
cord-277417-f71jwdzj	219	23	.	.	.
cord-277417-f71jwdzj	220	1	That	that	IN
cord-277417-f71jwdzj	220	2	the	the	DT
cord-277417-f71jwdzj	220	3	trajectory	trajectory	NN
cord-277417-f71jwdzj	220	4	of	of	IN
cord-277417-f71jwdzj	220	5	virulence	virulence	NN
cord-277417-f71jwdzj	220	6	evolution	evolution	NN
cord-277417-f71jwdzj	220	7	was	be	VBD
cord-277417-f71jwdzj	220	8	the	the	DT
cord-277417-f71jwdzj	220	9	same	same	JJ
cord-277417-f71jwdzj	220	10	in	in	IN
cord-277417-f71jwdzj	220	11	both	both	DT
cord-277417-f71jwdzj	220	12	Australia	Australia	NNP
cord-277417-f71jwdzj	220	13	and	and	CC
cord-277417-f71jwdzj	220	14	Europe	Europe	NNP
cord-277417-f71jwdzj	220	15	meant	mean	VBD
cord-277417-f71jwdzj	220	16	that	that	IN
cord-277417-f71jwdzj	220	17	the	the	DT
cord-277417-f71jwdzj	220	18	same	same	JJ
cord-277417-f71jwdzj	220	19	virulence	virulence	NN
cord-277417-f71jwdzj	220	20	determinants	determinant	NNS
cord-277417-f71jwdzj	220	21	might	may	MD
cord-277417-f71jwdzj	220	22	be	be	VB
cord-277417-f71jwdzj	220	23	involved	involve	VBN
cord-277417-f71jwdzj	220	24	on	on	IN
cord-277417-f71jwdzj	220	25	both	both	DT
cord-277417-f71jwdzj	220	26	continents	continent	NNS
cord-277417-f71jwdzj	220	27	.	.	.
cord-277417-f71jwdzj	221	1	Therefore	therefore	RB
cord-277417-f71jwdzj	221	2	,	,	,
cord-277417-f71jwdzj	221	3	it	-PRON-	PRP
cord-277417-f71jwdzj	221	4	was	be	VBD
cord-277417-f71jwdzj	221	5	a	a	DT
cord-277417-f71jwdzj	221	6	surprise	surprise	NN
cord-277417-f71jwdzj	221	7	when	when	WRB
cord-277417-f71jwdzj	221	8	the	the	DT
cord-277417-f71jwdzj	221	9	first	first	JJ
cord-277417-f71jwdzj	221	10	large	large	JJ
cord-277417-f71jwdzj	221	11	-	-	HYPH
cord-277417-f71jwdzj	221	12	scale	scale	NN
cord-277417-f71jwdzj	221	13	genome	genome	NN
cord-277417-f71jwdzj	221	14	comparisons	comparison	NNS
cord-277417-f71jwdzj	221	15	of	of	IN
cord-277417-f71jwdzj	221	16	MYXv	MYXv	NNS
cord-277417-f71jwdzj	221	17	revealed	reveal	VBD
cord-277417-f71jwdzj	221	18	that	that	IN
cord-277417-f71jwdzj	221	19	virulence	virulence	NN
cord-277417-f71jwdzj	221	20	grades	grade	NNS
cord-277417-f71jwdzj	221	21	changed	change	VBD
cord-277417-f71jwdzj	221	22	frequently	frequently	RB
cord-277417-f71jwdzj	221	23	across	across	IN
cord-277417-f71jwdzj	221	24	the	the	DT
cord-277417-f71jwdzj	221	25	virus	virus	NN
cord-277417-f71jwdzj	221	26	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	221	27	,	,	,
cord-277417-f71jwdzj	221	28	as	as	IN
cord-277417-f71jwdzj	221	29	depicted	depict	VBN
cord-277417-f71jwdzj	221	30	in	in	IN
cord-277417-f71jwdzj	221	31	the	the	DT
cord-277417-f71jwdzj	221	32	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	221	33	,	,	,
cord-277417-f71jwdzj	221	34	and	and	CC
cord-277417-f71jwdzj	221	35	that	that	IN
cord-277417-f71jwdzj	221	36	different	different	JJ
cord-277417-f71jwdzj	221	37	mutations	mutation	NNS
cord-277417-f71jwdzj	221	38	appeared	appear	VBD
cord-277417-f71jwdzj	221	39	in	in	IN
cord-277417-f71jwdzj	221	40	the	the	DT
cord-277417-f71jwdzj	221	41	Australian	australian	JJ
cord-277417-f71jwdzj	221	42	and	and	CC
cord-277417-f71jwdzj	221	43	European	european	JJ
cord-277417-f71jwdzj	221	44	epidemics	epidemic	NNS
cord-277417-f71jwdzj	221	45	(	(	-LRB-
cord-277417-f71jwdzj	221	46	depicted	depict	VBN
cord-277417-f71jwdzj	221	47	as	as	IN
cord-277417-f71jwdzj	221	48	different	different	JJ
cord-277417-f71jwdzj	221	49	filled	fill	VBN
cord-277417-f71jwdzj	221	50	shapes	shape	NNS
cord-277417-f71jwdzj	221	51	at	at	IN
cord-277417-f71jwdzj	221	52	branch	branch	NN
cord-277417-f71jwdzj	221	53	tips	tip	NNS
cord-277417-f71jwdzj	221	54	)	)	-RRB-
cord-277417-f71jwdzj	221	55	,	,	,
cord-277417-f71jwdzj	221	56	with	with	IN
cord-277417-f71jwdzj	221	57	no	no	DT
cord-277417-f71jwdzj	221	58	parallel	parallel	JJ
cord-277417-f71jwdzj	221	59	evolution	evolution	NN
cord-277417-f71jwdzj	221	60	of	of	IN
cord-277417-f71jwdzj	221	61	possible	possible	JJ
cord-277417-f71jwdzj	221	62	virulence	virulence	NN
cord-277417-f71jwdzj	221	63	determinants	determinant	NNS
cord-277417-f71jwdzj	221	64	within	within	IN
cord-277417-f71jwdzj	221	65	Australia	Australia	NNP
cord-277417-f71jwdzj	221	66	and	and	CC
cord-277417-f71jwdzj	221	67	Europe	Europe	NNP
cord-277417-f71jwdzj	221	68	94	94	CD
cord-277417-f71jwdzj	221	69	,	,	,
cord-277417-f71jwdzj	221	70	145	145	CD
cord-277417-f71jwdzj	221	71	.	.	.
cord-277417-f71jwdzj	222	1	For	for	IN
cord-277417-f71jwdzj	222	2	example	example	NN
cord-277417-f71jwdzj	222	3	,	,	,
cord-277417-f71jwdzj	222	4	there	there	EX
cord-277417-f71jwdzj	222	5	were	be	VBD
cord-277417-f71jwdzj	222	6	no	no	DT
cord-277417-f71jwdzj	222	7	mutations	mutation	NNS
cord-277417-f71jwdzj	222	8	that	that	WDT
cord-277417-f71jwdzj	222	9	were	be	VBD
cord-277417-f71jwdzj	222	10	unique	unique	JJ
cord-277417-f71jwdzj	222	11	to	to	IN
cord-277417-f71jwdzj	222	12	the	the	DT
cord-277417-f71jwdzj	222	13	most	most	RBS
cord-277417-f71jwdzj	222	14	attenuated	attenuated	JJ
cord-277417-f71jwdzj	222	15	grade	grade	NN
cord-277417-f71jwdzj	222	16	v	v	IN
cord-277417-f71jwdzj	222	17	viruses	virus	NNS
cord-277417-f71jwdzj	222	18	,	,	,
cord-277417-f71jwdzj	222	19	nor	nor	CC
cord-277417-f71jwdzj	222	20	to	to	IN
cord-277417-f71jwdzj	222	21	the	the	DT
cord-277417-f71jwdzj	222	22	highest	high	JJS
cord-277417-f71jwdzj	222	23	virulence	virulence	NN
cord-277417-f71jwdzj	222	24	grade	grade	NN
cord-277417-f71jwdzj	222	25	I	-PRON-	PRP
cord-277417-f71jwdzj	222	26	viruses	virus	NNS
cord-277417-f71jwdzj	222	27	.	.	.
cord-277417-f71jwdzj	223	1	Hence	hence	RB
cord-277417-f71jwdzj	223	2	,	,	,
cord-277417-f71jwdzj	223	3	there	there	EX
cord-277417-f71jwdzj	223	4	are	be	VBP
cord-277417-f71jwdzj	223	5	multiple	multiple	JJ
cord-277417-f71jwdzj	223	6	genetic	genetic	JJ
cord-277417-f71jwdzj	223	7	routes	route	NNS
cord-277417-f71jwdzj	223	8	to	to	IN
cord-277417-f71jwdzj	223	9	attenuation	attenuation	NN
cord-277417-f71jwdzj	223	10	or	or	CC
cord-277417-f71jwdzj	223	11	virulence	virulence	NN
cord-277417-f71jwdzj	223	12	in	in	IN
cord-277417-f71jwdzj	223	13	MYXv	MYXv	NNS
cord-277417-f71jwdzj	223	14	,	,	,
cord-277417-f71jwdzj	223	15	such	such	JJ
cord-277417-f71jwdzj	223	16	that	that	IN
cord-277417-f71jwdzj	223	17	there	there	EX
cord-277417-f71jwdzj	223	18	has	have	VBZ
cord-277417-f71jwdzj	223	19	been	be	VBN
cord-277417-f71jwdzj	223	20	convergent	convergent	JJ
cord-277417-f71jwdzj	223	21	evolution	evolution	NN
cord-277417-f71jwdzj	223	22	for	for	IN
cord-277417-f71jwdzj	223	23	phenotype	phenotype	NN
cord-277417-f71jwdzj	223	24	but	but	CC
cord-277417-f71jwdzj	223	25	not	not	RB
cord-277417-f71jwdzj	223	26	genotype	genotype	NN
cord-277417-f71jwdzj	223	27	,	,	,
cord-277417-f71jwdzj	223	28	and	and	CC
cord-277417-f71jwdzj	223	29	both	both	CC
cord-277417-f71jwdzj	223	30	attenuating	attenuate	VBG
cord-277417-f71jwdzj	223	31	and	and	CC
cord-277417-f71jwdzj	223	32	virulence	virulence	NN
cord-277417-f71jwdzj	223	33	-	-	HYPH
cord-277417-f71jwdzj	223	34	restoring	restore	VBG
cord-277417-f71jwdzj	223	35	mutations	mutation	NNS
cord-277417-f71jwdzj	223	36	have	have	VBP
cord-277417-f71jwdzj	223	37	been	be	VBN
cord-277417-f71jwdzj	223	38	fixed	fix	VBN
cord-277417-f71jwdzj	223	39	in	in	IN
cord-277417-f71jwdzj	223	40	Australian	australian	JJ
cord-277417-f71jwdzj	223	41	MYXv	MYXv	NNS
cord-277417-f71jwdzj	223	42	.	.	.
cord-277417-f71jwdzj	224	1	Therefore	therefore	RB
cord-277417-f71jwdzj	224	2	,	,	,
cord-277417-f71jwdzj	224	3	there	there	EX
cord-277417-f71jwdzj	224	4	is	be	VBZ
cord-277417-f71jwdzj	224	5	no	no	DT
cord-277417-f71jwdzj	224	6	simple	simple	JJ
cord-277417-f71jwdzj	224	7	way	way	NN
cord-277417-f71jwdzj	224	8	to	to	TO
cord-277417-f71jwdzj	224	9	predict	predict	VB
cord-277417-f71jwdzj	224	10	virulence	virulence	NN
cord-277417-f71jwdzj	224	11	evolution	evolution	NN
cord-277417-f71jwdzj	224	12	from	from	IN
cord-277417-f71jwdzj	224	13	genome	genome	NN
cord-277417-f71jwdzj	224	14	-	-	HYPH
cord-277417-f71jwdzj	224	15	scale	scale	NN
cord-277417-f71jwdzj	224	16	comparisons	comparison	NNS
cord-277417-f71jwdzj	224	17	in	in	IN
cord-277417-f71jwdzj	224	18	the	the	DT
cord-277417-f71jwdzj	224	19	case	case	NN
cord-277417-f71jwdzj	224	20	of	of	IN
cord-277417-f71jwdzj	224	21	MYXv	MYXv	NNS
cord-277417-f71jwdzj	224	22	and	and	CC
cord-277417-f71jwdzj	224	23	no	no	DT
cord-277417-f71jwdzj	224	24	parallel	parallel	JJ
cord-277417-f71jwdzj	224	25	or	or	CC
cord-277417-f71jwdzj	224	26	convergent	convergent	JJ
cord-277417-f71jwdzj	224	27	evolution	evolution	NN
cord-277417-f71jwdzj	224	28	to	to	TO
cord-277417-f71jwdzj	224	29	guide	guide	VB
cord-277417-f71jwdzj	224	30	experimentation	experimentation	NN
cord-277417-f71jwdzj	224	31	.	.	.
cord-277417-f71jwdzj	225	1	Indeed	indeed	RB
cord-277417-f71jwdzj	225	2	,	,	,
cord-277417-f71jwdzj	225	3	experimentally	experimentally	RB
cord-277417-f71jwdzj	225	4	verified	verify	VBN
cord-277417-f71jwdzj	225	5	virulence	virulence	NN
cord-277417-f71jwdzj	225	6	determinants	determinant	NNS
cord-277417-f71jwdzj	225	7	in	in	IN
cord-277417-f71jwdzj	225	8	rabbits	rabbit	NNS
cord-277417-f71jwdzj	225	9	remain	remain	VBP
cord-277417-f71jwdzj	225	10	elusive	elusive	JJ
cord-277417-f71jwdzj	225	11	17	17	CD
cord-277417-f71jwdzj	225	12	.	.	.
cord-277417-f71jwdzj	226	1	The	the	DT
cord-277417-f71jwdzj	226	2	ongoing	ongoing	JJ
cord-277417-f71jwdzj	226	3	evolution	evolution	NN
cord-277417-f71jwdzj	226	4	of	of	IN
cord-277417-f71jwdzj	226	5	MYXv	MYXv	NNS
cord-277417-f71jwdzj	226	6	virulence	virulence	NN
cord-277417-f71jwdzj	226	7	reflects	reflect	VBZ
cord-277417-f71jwdzj	226	8	both	both	DT
cord-277417-f71jwdzj	226	9	mutations	mutation	NNS
cord-277417-f71jwdzj	226	10	acquired	acquire	VBN
cord-277417-f71jwdzj	226	11	in	in	IN
cord-277417-f71jwdzj	226	12	the	the	DT
cord-277417-f71jwdzj	226	13	virus	virus	NN
cord-277417-f71jwdzj	226	14	and	and	CC
cord-277417-f71jwdzj	226	15	resistance	resistance	NN
cord-277417-f71jwdzj	226	16	evolution	evolution	NN
cord-277417-f71jwdzj	226	17	in	in	IN
cord-277417-f71jwdzj	226	18	the	the	DT
cord-277417-f71jwdzj	226	19	rabbit	rabbit	NN
cord-277417-f71jwdzj	226	20	host	host	NN
cord-277417-f71jwdzj	226	21	11	11	CD
cord-277417-f71jwdzj	226	22	.	.	.
cord-277417-f71jwdzj	227	1	This	this	DT
cord-277417-f71jwdzj	227	2	co	co	JJ
cord-277417-f71jwdzj	227	3	-	-	JJ
cord-277417-f71jwdzj	227	4	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	227	5	process	process	NN
cord-277417-f71jwdzj	227	6	has	have	VBZ
cord-277417-f71jwdzj	227	7	also	also	RB
cord-277417-f71jwdzj	227	8	resulted	result	VBN
cord-277417-f71jwdzj	227	9	in	in	IN
cord-277417-f71jwdzj	227	10	a	a	DT
cord-277417-f71jwdzj	227	11	marked	marked	JJ
cord-277417-f71jwdzj	227	12	increase	increase	NN
cord-277417-f71jwdzj	227	13	in	in	IN
cord-277417-f71jwdzj	227	14	MYXv	MYXv	NNS
cord-277417-f71jwdzj	227	15	virulence	virulence	NN
cord-277417-f71jwdzj	227	16	146	146	CD
cord-277417-f71jwdzj	227	17	.	.	.
cord-277417-f71jwdzj	228	1	unlike	unlike	IN
cord-277417-f71jwdzj	228	2	viruses	virus	NNS
cord-277417-f71jwdzj	228	3	sampled	sample	VBN
cord-277417-f71jwdzj	228	4	in	in	IN
cord-277417-f71jwdzj	228	5	the	the	DT
cord-277417-f71jwdzj	228	6	1950s	1950	NNS
cord-277417-f71jwdzj	228	7	before	before	IN
cord-277417-f71jwdzj	228	8	the	the	DT
cord-277417-f71jwdzj	228	9	evolution	evolution	NN
cord-277417-f71jwdzj	228	10	of	of	IN
cord-277417-f71jwdzj	228	11	any	any	DT
cord-277417-f71jwdzj	228	12	host	host	NN
cord-277417-f71jwdzj	228	13	resistance	resistance	NN
cord-277417-f71jwdzj	228	14	,	,	,
cord-277417-f71jwdzj	228	15	most	most	JJS
cord-277417-f71jwdzj	228	16	virus	virus	NN
cord-277417-f71jwdzj	228	17	isolates	isolate	NNS
cord-277417-f71jwdzj	228	18	sampled	sample	VBN
cord-277417-f71jwdzj	228	19	in	in	IN
cord-277417-f71jwdzj	228	20	the	the	DT
cord-277417-f71jwdzj	228	21	1990s	1990	NNS
cord-277417-f71jwdzj	228	22	that	that	WDT
cord-277417-f71jwdzj	228	23	have	have	VBP
cord-277417-f71jwdzj	228	24	evolved	evolve	VBN
cord-277417-f71jwdzj	228	25	in	in	IN
cord-277417-f71jwdzj	228	26	the	the	DT
cord-277417-f71jwdzj	228	27	face	face	NN
cord-277417-f71jwdzj	228	28	of	of	IN
cord-277417-f71jwdzj	228	29	host	host	NN
cord-277417-f71jwdzj	228	30	resistance	resistance	NN
cord-277417-f71jwdzj	228	31	induce	induce	VB
cord-277417-f71jwdzj	228	32	a	a	DT
cord-277417-f71jwdzj	228	33	lethal	lethal	JJ
cord-277417-f71jwdzj	228	34	immune	immune	JJ
cord-277417-f71jwdzj	228	35	collapse	collapse	NN
cord-277417-f71jwdzj	228	36	syndrome	syndrome	NN
cord-277417-f71jwdzj	228	37	with	with	IN
cord-277417-f71jwdzj	228	38	similarities	similarity	NNS
cord-277417-f71jwdzj	228	39	to	to	TO
cord-277417-f71jwdzj	228	40	septic	septic	JJ
cord-277417-f71jwdzj	228	41	shock	shock	NN
cord-277417-f71jwdzj	228	42	146	146	CD
cord-277417-f71jwdzj	228	43	.	.	.
cord-277417-f71jwdzj	229	1	may	may	MD
cord-277417-f71jwdzj	229	2	have	have	VB
cord-277417-f71jwdzj	229	3	been	be	VBN
cord-277417-f71jwdzj	229	4	responsible	responsible	JJ
cord-277417-f71jwdzj	229	5	for	for	IN
cord-277417-f71jwdzj	229	6	a	a	DT
cord-277417-f71jwdzj	229	7	substantial	substantial	JJ
cord-277417-f71jwdzj	229	8	proportion	proportion	NN
cord-277417-f71jwdzj	229	9	for	for	IN
cord-277417-f71jwdzj	229	10	the	the	DT
cord-277417-f71jwdzj	229	11	cross	cross	JJ
cord-277417-f71jwdzj	229	12	-	-	JJ
cord-277417-f71jwdzj	229	13	continent	continent	JJ
cord-277417-f71jwdzj	229	14	spread	spread	NN
cord-277417-f71jwdzj	229	15	of	of	IN
cord-277417-f71jwdzj	229	16	the	the	DT
cord-277417-f71jwdzj	229	17	virus	virus	NN
cord-277417-f71jwdzj	229	18	74	74	CD
cord-277417-f71jwdzj	229	19	,	,	,
cord-277417-f71jwdzj	229	20	in	in	IN
cord-277417-f71jwdzj	229	21	which	which	WDT
cord-277417-f71jwdzj	229	22	case	case	NN
cord-277417-f71jwdzj	229	23	T249P	t249p	NN
cord-277417-f71jwdzj	229	24	may	may	MD
cord-277417-f71jwdzj	229	25	have	have	VB
cord-277417-f71jwdzj	229	26	been	be	VBN
cord-277417-f71jwdzj	229	27	selected	select	VBN
cord-277417-f71jwdzj	229	28	to	to	TO
cord-277417-f71jwdzj	229	29	increase	increase	VB
cord-277417-f71jwdzj	229	30	replication	replication	NN
cord-277417-f71jwdzj	229	31	(	(	-LRB-
cord-277417-f71jwdzj	229	32	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	229	33	)	)	-RRB-
cord-277417-f71jwdzj	229	34	in	in	IN
cord-277417-f71jwdzj	229	35	that	that	DT
cord-277417-f71jwdzj	229	36	species	species	NN
cord-277417-f71jwdzj	230	1	,	,	,
cord-277417-f71jwdzj	230	2	a	a	DT
cord-277417-f71jwdzj	230	3	coincidental	coincidental	JJ
cord-277417-f71jwdzj	230	4	by	by	IN
cord-277417-f71jwdzj	230	5	-	-	HYPH
cord-277417-f71jwdzj	230	6	product	product	NN
cord-277417-f71jwdzj	230	7	of	of	IN
cord-277417-f71jwdzj	230	8	which	which	WDT
cord-277417-f71jwdzj	230	9	was	be	VBD
cord-277417-f71jwdzj	230	10	heightened	heighten	VBN
cord-277417-f71jwdzj	230	11	virulence	virulence	NN
cord-277417-f71jwdzj	230	12	in	in	IN
cord-277417-f71jwdzj	230	13	crows	crow	NNS
cord-277417-f71jwdzj	230	14	.	.	.
cord-277417-f71jwdzj	231	1	Ever	ever	RB
cord-277417-f71jwdzj	231	2	since	since	IN
cord-277417-f71jwdzj	231	3	the	the	DT
cord-277417-f71jwdzj	231	4	emergence	emergence	NN
cord-277417-f71jwdzj	231	5	of	of	IN
cord-277417-f71jwdzj	231	6	the	the	DT
cord-277417-f71jwdzj	231	7	highly	highly	RB
cord-277417-f71jwdzj	231	8	pathogenic	pathogenic	JJ
cord-277417-f71jwdzj	231	9	H5N1	H5N1	NNP
cord-277417-f71jwdzj	231	10	subtype	subtype	NN
cord-277417-f71jwdzj	231	11	of	of	IN
cord-277417-f71jwdzj	231	12	influenza	influenza	NN
cord-277417-f71jwdzj	231	13	virus	virus	NN
cord-277417-f71jwdzj	231	14	,	,	,
cord-277417-f71jwdzj	231	15	there	there	EX
cord-277417-f71jwdzj	231	16	has	have	VBZ
cord-277417-f71jwdzj	231	17	been	be	VBN
cord-277417-f71jwdzj	231	18	concern	concern	NN
cord-277417-f71jwdzj	231	19	over	over	IN
cord-277417-f71jwdzj	231	20	whether	whether	IN
cord-277417-f71jwdzj	231	21	this	this	DT
cord-277417-f71jwdzj	231	22	influenza	influenza	NN
cord-277417-f71jwdzj	231	23	virus	virus	NN
cord-277417-f71jwdzj	231	24	could	could	MD
cord-277417-f71jwdzj	231	25	establish	establish	VB
cord-277417-f71jwdzj	231	26	sustained	sustained	JJ
cord-277417-f71jwdzj	231	27	transmission	transmission	NN
cord-277417-f71jwdzj	231	28	in	in	IN
cord-277417-f71jwdzj	231	29	humans	human	NNS
cord-277417-f71jwdzj	231	30	,	,	,
cord-277417-f71jwdzj	231	31	in	in	IN
cord-277417-f71jwdzj	231	32	which	which	WDT
cord-277417-f71jwdzj	231	33	it	-PRON-	PRP
cord-277417-f71jwdzj	231	34	causes	cause	VBZ
cord-277417-f71jwdzj	231	35	only	only	RB
cord-277417-f71jwdzj	231	36	sporadic	sporadic	JJ
cord-277417-f71jwdzj	231	37	spillover	spillover	NN
cord-277417-f71jwdzj	231	38	infections	infection	NNS
cord-277417-f71jwdzj	231	39	at	at	IN
cord-277417-f71jwdzj	231	40	present	present	JJ
cord-277417-f71jwdzj	231	41	75	75	CD
cord-277417-f71jwdzj	231	42	,	,	,
cord-277417-f71jwdzj	231	43	76	76	CD
cord-277417-f71jwdzj	231	44	.	.	.
cord-277417-f71jwdzj	232	1	More	more	RBR
cord-277417-f71jwdzj	232	2	recently	recently	RB
cord-277417-f71jwdzj	232	3	,	,	,
cord-277417-f71jwdzj	232	4	highly	highly	RB
cord-277417-f71jwdzj	232	5	pathogenic	pathogenic	JJ
cord-277417-f71jwdzj	232	6	H7N9	H7N9	NNP
cord-277417-f71jwdzj	232	7	has	have	VBZ
cord-277417-f71jwdzj	232	8	sporadically	sporadically	RB
cord-277417-f71jwdzj	232	9	infected	infect	VBN
cord-277417-f71jwdzj	232	10	humans	human	NNS
cord-277417-f71jwdzj	232	11	77	77	CD
cord-277417-f71jwdzj	232	12	and	and	CC
cord-277417-f71jwdzj	232	13	continues	continue	VBZ
cord-277417-f71jwdzj	232	14	to	to	TO
cord-277417-f71jwdzj	232	15	spread	spread	VB
cord-277417-f71jwdzj	232	16	through	through	IN
cord-277417-f71jwdzj	232	17	poultry	poultry	NN
cord-277417-f71jwdzj	232	18	populations	population	NNS
cord-277417-f71jwdzj	232	19	in	in	IN
cord-277417-f71jwdzj	232	20	China	China	NNP
cord-277417-f71jwdzj	232	21	78	78	CD
cord-277417-f71jwdzj	232	22	,	,	,
cord-277417-f71jwdzj	232	23	evolving	evolve	VBG
cord-277417-f71jwdzj	232	24	from	from	IN
cord-277417-f71jwdzj	232	25	a	a	DT
cord-277417-f71jwdzj	232	26	low	low	JJ
cord-277417-f71jwdzj	232	27	-	-	HYPH
cord-277417-f71jwdzj	232	28	virulence	virulence	NN
cord-277417-f71jwdzj	232	29	ancestor	ancestor	NN
cord-277417-f71jwdzj	232	30	79	79	CD
cord-277417-f71jwdzj	232	31	.	.	.
cord-277417-f71jwdzj	233	1	Although	although	IN
cord-277417-f71jwdzj	233	2	the	the	DT
cord-277417-f71jwdzj	233	3	true	true	JJ
cord-277417-f71jwdzj	233	4	number	number	NN
cord-277417-f71jwdzj	233	5	of	of	IN
cord-277417-f71jwdzj	233	6	human	human	JJ
cord-277417-f71jwdzj	233	7	cases	case	NNS
cord-277417-f71jwdzj	233	8	,	,	,
cord-277417-f71jwdzj	233	9	and	and	CC
cord-277417-f71jwdzj	233	10	hence	hence	RB
cord-277417-f71jwdzj	233	11	accurate	accurate	JJ
cord-277417-f71jwdzj	233	12	mortality	mortality	NN
cord-277417-f71jwdzj	233	13	,	,	,
cord-277417-f71jwdzj	233	14	is	be	VBZ
cord-277417-f71jwdzj	233	15	difficult	difficult	JJ
cord-277417-f71jwdzj	233	16	to	to	TO
cord-277417-f71jwdzj	233	17	ascertain	ascertain	VB
cord-277417-f71jwdzj	233	18	,	,	,
cord-277417-f71jwdzj	233	19	it	-PRON-	PRP
cord-277417-f71jwdzj	233	20	is	be	VBZ
cord-277417-f71jwdzj	233	21	clear	clear	JJ
cord-277417-f71jwdzj	233	22	that	that	IN
cord-277417-f71jwdzj	233	23	both	both	DT
cord-277417-f71jwdzj	233	24	H5N1	H5N1	NNP
cord-277417-f71jwdzj	233	25	and	and	CC
cord-277417-f71jwdzj	233	26	H7N9	H7N9	NNP
cord-277417-f71jwdzj	233	27	cause	cause	VB
cord-277417-f71jwdzj	233	28	fairly	fairly	RB
cord-277417-f71jwdzj	233	29	high	high	JJ
cord-277417-f71jwdzj	233	30	mortality	mortality	NN
cord-277417-f71jwdzj	233	31	in	in	IN
cord-277417-f71jwdzj	233	32	humans	human	NNS
cord-277417-f71jwdzj	233	33	and	and	CC
cord-277417-f71jwdzj	233	34	could	could	MD
cord-277417-f71jwdzj	233	35	have	have	VB
cord-277417-f71jwdzj	233	36	serious	serious	JJ
cord-277417-f71jwdzj	233	37	consequences	consequence	NNS
cord-277417-f71jwdzj	233	38	were	be	VBD
cord-277417-f71jwdzj	233	39	they	-PRON-	PRP
cord-277417-f71jwdzj	233	40	to	to	TO
cord-277417-f71jwdzj	233	41	trigger	trigger	VB
cord-277417-f71jwdzj	233	42	a	a	DT
cord-277417-f71jwdzj	233	43	large	large	JJ
cord-277417-f71jwdzj	233	44	-	-	HYPH
cord-277417-f71jwdzj	233	45	scale	scale	NN
cord-277417-f71jwdzj	233	46	human	human	JJ
cord-277417-f71jwdzj	233	47	epidemic	epidemic	NN
cord-277417-f71jwdzj	233	48	.	.	.
cord-277417-f71jwdzj	234	1	This	this	DT
cord-277417-f71jwdzj	234	2	concern	concern	NN
cord-277417-f71jwdzj	234	3	has	have	VBZ
cord-277417-f71jwdzj	234	4	led	lead	VBN
cord-277417-f71jwdzj	234	5	to	to	IN
cord-277417-f71jwdzj	234	6	attempts	attempt	NNS
cord-277417-f71jwdzj	234	7	to	to	TO
cord-277417-f71jwdzj	234	8	use	use	VB
cord-277417-f71jwdzj	234	9	genomic	genomic	JJ
cord-277417-f71jwdzj	234	10	data	datum	NNS
cord-277417-f71jwdzj	234	11	to	to	TO
cord-277417-f71jwdzj	234	12	help	help	VB
cord-277417-f71jwdzj	234	13	in	in	IN
cord-277417-f71jwdzj	234	14	pandemic	pandemic	JJ
cord-277417-f71jwdzj	234	15	risk	risk	NN
cord-277417-f71jwdzj	234	16	assessment	assessment	NN
cord-277417-f71jwdzj	234	17	80	80	CD
cord-277417-f71jwdzj	234	18	.	.	.
cord-277417-f71jwdzj	235	1	At	at	IN
cord-277417-f71jwdzj	235	2	the	the	DT
cord-277417-f71jwdzj	235	3	virus	virus	NN
cord-277417-f71jwdzj	235	4	subtype	subtype	NN
cord-277417-f71jwdzj	235	5	level	level	NN
cord-277417-f71jwdzj	235	6	,	,	,
cord-277417-f71jwdzj	235	7	the	the	DT
cord-277417-f71jwdzj	235	8	presence	presence	NN
cord-277417-f71jwdzj	235	9	of	of	IN
cord-277417-f71jwdzj	235	10	a	a	DT
cord-277417-f71jwdzj	235	11	run	run	NN
cord-277417-f71jwdzj	235	12	of	of	IN
cord-277417-f71jwdzj	235	13	polybasic	polybasic	JJ
cord-277417-f71jwdzj	235	14	amino	amino	NN
cord-277417-f71jwdzj	235	15	acids	acid	NNS
cord-277417-f71jwdzj	235	16	in	in	IN
cord-277417-f71jwdzj	235	17	the	the	DT
cord-277417-f71jwdzj	235	18	hinge	hinge	NN
cord-277417-f71jwdzj	235	19	region	region	NN
cord-277417-f71jwdzj	235	20	between	between	IN
cord-277417-f71jwdzj	235	21	the	the	DT
cord-277417-f71jwdzj	235	22	HA1	HA1	NNP
cord-277417-f71jwdzj	235	23	and	and	CC
cord-277417-f71jwdzj	235	24	HA2	HA2	NNP
cord-277417-f71jwdzj	235	25	subunits	subunit	NNS
cord-277417-f71jwdzj	235	26	that	that	WDT
cord-277417-f71jwdzj	235	27	make	make	VBP
cord-277417-f71jwdzj	235	28	up	up	RP
cord-277417-f71jwdzj	235	29	the	the	DT
cord-277417-f71jwdzj	235	30	haemagglutinin	haemagglutinin	NNP
cord-277417-f71jwdzj	236	1	(	(	-LRB-
cord-277417-f71jwdzj	236	2	HA	HA	NNP
cord-277417-f71jwdzj	236	3	)	)	-RRB-
cord-277417-f71jwdzj	236	4	protein	protein	NN
cord-277417-f71jwdzj	236	5	of	of	IN
cord-277417-f71jwdzj	236	6	influenza	influenza	NN
cord-277417-f71jwdzj	236	7	virus	virus	NN
cord-277417-f71jwdzj	236	8	helps	help	VBZ
cord-277417-f71jwdzj	236	9	it	-PRON-	PRP
cord-277417-f71jwdzj	236	10	establish	establish	VB
cord-277417-f71jwdzj	236	11	a	a	DT
cord-277417-f71jwdzj	236	12	systemic	systemic	JJ
cord-277417-f71jwdzj	236	13	,	,	,
cord-277417-f71jwdzj	236	14	and	and	CC
cord-277417-f71jwdzj	236	15	subsequently	subsequently	RB
cord-277417-f71jwdzj	236	16	more	more	RBR
cord-277417-f71jwdzj	236	17	serious	serious	JJ
cord-277417-f71jwdzj	236	18	,	,	,
cord-277417-f71jwdzj	236	19	infection	infection	NN
cord-277417-f71jwdzj	236	20	and	and	CC
cord-277417-f71jwdzj	236	21	thereby	thereby	RB
cord-277417-f71jwdzj	236	22	acts	act	VBZ
cord-277417-f71jwdzj	236	23	as	as	IN
cord-277417-f71jwdzj	236	24	a	a	DT
cord-277417-f71jwdzj	236	25	useful	useful	JJ
cord-277417-f71jwdzj	236	26	marker	marker	NN
cord-277417-f71jwdzj	236	27	of	of	IN
cord-277417-f71jwdzj	236	28	high	high	JJ
cord-277417-f71jwdzj	236	29	-	-	HYPH
cord-277417-f71jwdzj	236	30	virulence	virulence	NN
cord-277417-f71jwdzj	236	31	strains	strain	NNS
cord-277417-f71jwdzj	236	32	of	of	IN
cord-277417-f71jwdzj	236	33	the	the	DT
cord-277417-f71jwdzj	236	34	H5	H5	NNP
cord-277417-f71jwdzj	236	35	and	and	CC
cord-277417-f71jwdzj	236	36	H7	H7	NNP
cord-277417-f71jwdzj	236	37	AIV	AIV	NNP
cord-277417-f71jwdzj	236	38	subtypes	subtype	NNS
cord-277417-f71jwdzj	236	39	79	79	CD
cord-277417-f71jwdzj	236	40	,	,	,
cord-277417-f71jwdzj	236	41	81	81	CD
cord-277417-f71jwdzj	236	42	,	,	,
cord-277417-f71jwdzj	236	43	82	82	CD
cord-277417-f71jwdzj	236	44	.	.	.
cord-277417-f71jwdzj	237	1	This	this	DT
cord-277417-f71jwdzj	237	2	marker	marker	NN
cord-277417-f71jwdzj	237	3	makes	make	VBZ
cord-277417-f71jwdzj	237	4	it	-PRON-	PRP
cord-277417-f71jwdzj	237	5	relatively	relatively	RB
cord-277417-f71jwdzj	237	6	easy	easy	JJ
cord-277417-f71jwdzj	237	7	to	to	TO
cord-277417-f71jwdzj	237	8	distinguish	distinguish	VB
cord-277417-f71jwdzj	237	9	between	between	IN
cord-277417-f71jwdzj	237	10	potentially	potentially	RB
cord-277417-f71jwdzj	237	11	lowvirulence	lowvirulence	NN
cord-277417-f71jwdzj	237	12	and	and	CC
cord-277417-f71jwdzj	237	13	high	high	JJ
cord-277417-f71jwdzj	237	14	-	-	HYPH
cord-277417-f71jwdzj	237	15	virulence	virulence	NN
cord-277417-f71jwdzj	237	16	AIVs	aiv	NNS
cord-277417-f71jwdzj	237	17	,	,	,
cord-277417-f71jwdzj	237	18	although	although	IN
cord-277417-f71jwdzj	237	19	what	what	WP
cord-277417-f71jwdzj	237	20	triggers	trigger	VBZ
cord-277417-f71jwdzj	237	21	the	the	DT
cord-277417-f71jwdzj	237	22	evolution	evolution	NN
cord-277417-f71jwdzj	237	23	of	of	IN
cord-277417-f71jwdzj	237	24	the	the	DT
cord-277417-f71jwdzj	237	25	high	high	JJ
cord-277417-f71jwdzj	237	26	-	-	HYPH
cord-277417-f71jwdzj	237	27	pathogenicity	pathogenicity	NN
cord-277417-f71jwdzj	237	28	variants	variant	NNS
cord-277417-f71jwdzj	237	29	in	in	IN
cord-277417-f71jwdzj	237	30	these	these	DT
cord-277417-f71jwdzj	237	31	subtypes	subtype	NNS
cord-277417-f71jwdzj	237	32	is	be	VBZ
cord-277417-f71jwdzj	237	33	unclear	unclear	JJ
cord-277417-f71jwdzj	237	34	83	83	CD
cord-277417-f71jwdzj	237	35	.	.	.
cord-277417-f71jwdzj	238	1	Other	other	JJ
cord-277417-f71jwdzj	238	2	individual	individual	JJ
cord-277417-f71jwdzj	238	3	amino	amino	NN
cord-277417-f71jwdzj	238	4	acid	acid	NN
cord-277417-f71jwdzj	238	5	changes	change	NNS
cord-277417-f71jwdzj	238	6	,	,	,
cord-277417-f71jwdzj	238	7	affecting	affect	VBG
cord-277417-f71jwdzj	238	8	a	a	DT
cord-277417-f71jwdzj	238	9	variety	variety	NN
cord-277417-f71jwdzj	238	10	of	of	IN
cord-277417-f71jwdzj	238	11	gene	gene	NN
cord-277417-f71jwdzj	238	12	functions	function	NNS
cord-277417-f71jwdzj	238	13	,	,	,
cord-277417-f71jwdzj	238	14	have	have	VBP
cord-277417-f71jwdzj	238	15	also	also	RB
cord-277417-f71jwdzj	238	16	been	be	VBN
cord-277417-f71jwdzj	238	17	proposed	propose	VBN
cord-277417-f71jwdzj	238	18	as	as	IN
cord-277417-f71jwdzj	238	19	specific	specific	JJ
cord-277417-f71jwdzj	238	20	virulence	virulence	NN
cord-277417-f71jwdzj	238	21	determinants	determinant	NNS
cord-277417-f71jwdzj	238	22	for	for	IN
cord-277417-f71jwdzj	238	23	H5N1	H5N1	NNP
cord-277417-f71jwdzj	239	1	(	(	-LRB-
cord-277417-f71jwdzj	239	2	ReFS	ReFS	NNP
cord-277417-f71jwdzj	239	3	84	84	CD
cord-277417-f71jwdzj	239	4	-	-	SYM
cord-277417-f71jwdzj	239	5	86	86	CD
cord-277417-f71jwdzj	239	6	)	)	-RRB-
cord-277417-f71jwdzj	239	7	as	as	RB
cord-277417-f71jwdzj	239	8	well	well	RB
cord-277417-f71jwdzj	239	9	as	as	IN
cord-277417-f71jwdzj	239	10	in	in	IN
cord-277417-f71jwdzj	239	11	those	those	DT
cord-277417-f71jwdzj	239	12	viruses	virus	NNS
cord-277417-f71jwdzj	239	13	that	that	WDT
cord-277417-f71jwdzj	239	14	circulate	circulate	VBP
cord-277417-f71jwdzj	239	15	in	in	IN
cord-277417-f71jwdzj	239	16	human	human	JJ
cord-277417-f71jwdzj	239	17	populations	population	NNS
cord-277417-f71jwdzj	239	18	such	such	JJ
cord-277417-f71jwdzj	239	19	as	as	IN
cord-277417-f71jwdzj	239	20	seasonal	seasonal	JJ
cord-277417-f71jwdzj	239	21	H3N2	H3N2	NNP
cord-277417-f71jwdzj	239	22	(	(	-LRB-
cord-277417-f71jwdzj	239	23	ReF.	ReF.	NNP
cord-277417-f71jwdzj	239	24	87	87	CD
cord-277417-f71jwdzj	239	25	)	)	-RRB-
cord-277417-f71jwdzj	239	26	,	,	,
cord-277417-f71jwdzj	239	27	the	the	DT
cord-277417-f71jwdzj	239	28	H1N1	H1N1	NNP
cord-277417-f71jwdzj	239	29	virus	virus	NN
cord-277417-f71jwdzj	239	30	responsible	responsible	JJ
cord-277417-f71jwdzj	239	31	for	for	IN
cord-277417-f71jwdzj	239	32	the	the	DT
cord-277417-f71jwdzj	239	33	global	global	JJ
cord-277417-f71jwdzj	239	34	pandemic	pandemic	NN
cord-277417-f71jwdzj	239	35	of	of	IN
cord-277417-f71jwdzj	239	36	1918	1918	CD
cord-277417-f71jwdzj	239	37	-	-	SYM
cord-277417-f71jwdzj	239	38	1919	1919	CD
cord-277417-f71jwdzj	239	39	(	(	-LRB-
cord-277417-f71jwdzj	239	40	ReF.	ReF.	NNP
cord-277417-f71jwdzj	239	41	88	88	CD
cord-277417-f71jwdzj	239	42	)	)	-RRB-
cord-277417-f71jwdzj	239	43	(	(	-LRB-
cord-277417-f71jwdzj	239	44	in	in	IN
cord-277417-f71jwdzj	239	45	which	which	WDT
cord-277417-f71jwdzj	239	46	host	host	VBP
cord-277417-f71jwdzj	239	47	inflammatory	inflammatory	JJ
cord-277417-f71jwdzj	239	48	and	and	CC
cord-277417-f71jwdzj	239	49	cell	cell	NN
cord-277417-f71jwdzj	239	50	death	death	NN
cord-277417-f71jwdzj	239	51	responses	response	NNS
cord-277417-f71jwdzj	239	52	to	to	IN
cord-277417-f71jwdzj	239	53	infection	infection	NN
cord-277417-f71jwdzj	239	54	appear	appear	VBP
cord-277417-f71jwdzj	239	55	to	to	TO
cord-277417-f71jwdzj	239	56	play	play	VB
cord-277417-f71jwdzj	239	57	a	a	DT
cord-277417-f71jwdzj	239	58	key	key	JJ
cord-277417-f71jwdzj	239	59	role	role	NN
cord-277417-f71jwdzj	239	60	)	)	-RRB-
cord-277417-f71jwdzj	239	61	89	89	CD
cord-277417-f71jwdzj	239	62	,	,	,
cord-277417-f71jwdzj	239	63	and	and	CC
cord-277417-f71jwdzj	239	64	influenza	influenza	NN
cord-277417-f71jwdzj	239	65	B	b	NN
cord-277417-f71jwdzj	239	66	virus	virus	NN
cord-277417-f71jwdzj	239	67	90	90	CD
cord-277417-f71jwdzj	239	68	(	(	-LRB-
cord-277417-f71jwdzj	239	69	TAble	table	JJ
cord-277417-f71jwdzj	239	70	1	1	CD
cord-277417-f71jwdzj	239	71	)	)	-RRB-
cord-277417-f71jwdzj	239	72	.	.	.
cord-277417-f71jwdzj	240	1	The	the	DT
cord-277417-f71jwdzj	240	2	key	key	JJ
cord-277417-f71jwdzj	240	3	unresolved	unresolved	JJ
cord-277417-f71jwdzj	240	4	question	question	NN
cord-277417-f71jwdzj	240	5	is	be	VBZ
cord-277417-f71jwdzj	240	6	how	how	WRB
cord-277417-f71jwdzj	240	7	natural	natural	JJ
cord-277417-f71jwdzj	240	8	selection	selection	NN
cord-277417-f71jwdzj	240	9	will	will	MD
cord-277417-f71jwdzj	240	10	shape	shape	VB
cord-277417-f71jwdzj	240	11	both	both	DT
cord-277417-f71jwdzj	240	12	virulence	virulence	NN
cord-277417-f71jwdzj	240	13	and	and	CC
cord-277417-f71jwdzj	240	14	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	240	15	if	if	IN
cord-277417-f71jwdzj	240	16	an	an	DT
cord-277417-f71jwdzj	240	17	AIVlike	aivlike	JJ
cord-277417-f71jwdzj	240	18	H5N1	H5N1	NNP
cord-277417-f71jwdzj	240	19	or	or	CC
cord-277417-f71jwdzj	240	20	H7N9	H7N9	NNP
cord-277417-f71jwdzj	240	21	virus	virus	NN
cord-277417-f71jwdzj	240	22	is	be	VBZ
cord-277417-f71jwdzj	240	23	eventually	eventually	RB
cord-277417-f71jwdzj	240	24	able	able	JJ
cord-277417-f71jwdzj	240	25	to	to	TO
cord-277417-f71jwdzj	240	26	develop	develop	VB
cord-277417-f71jwdzj	240	27	sustained	sustained	JJ
cord-277417-f71jwdzj	240	28	transmission	transmission	NN
cord-277417-f71jwdzj	240	29	in	in	IN
cord-277417-f71jwdzj	240	30	humans	human	NNS
cord-277417-f71jwdzj	240	31	.	.	.
cord-277417-f71jwdzj	241	1	An	an	DT
cord-277417-f71jwdzj	241	2	added	add	VBN
cord-277417-f71jwdzj	241	3	complexity	complexity	NN
cord-277417-f71jwdzj	241	4	is	be	VBZ
cord-277417-f71jwdzj	241	5	that	that	IN
cord-277417-f71jwdzj	241	6	phylogenomic	phylogenomic	NNP
cord-277417-f71jwdzj	241	7	analyses	analysis	NNS
cord-277417-f71jwdzj	241	8	reveal	reveal	VBP
cord-277417-f71jwdzj	241	9	a	a	DT
cord-277417-f71jwdzj	241	10	consistent	consistent	JJ
cord-277417-f71jwdzj	241	11	set	set	NN
cord-277417-f71jwdzj	241	12	of	of	IN
cord-277417-f71jwdzj	241	13	mutations	mutation	NNS
cord-277417-f71jwdzj	241	14	that	that	WDT
cord-277417-f71jwdzj	241	15	distinguish	distinguish	VBP
cord-277417-f71jwdzj	241	16	human	human	JJ
cord-277417-f71jwdzj	241	17	and	and	CC
cord-277417-f71jwdzj	241	18	avian	avian	JJ
cord-277417-f71jwdzj	241	19	influenza	influenza	NN
cord-277417-f71jwdzj	241	20	viruses	virus	NNS
cord-277417-f71jwdzj	241	21	,	,	,
cord-277417-f71jwdzj	241	22	although	although	IN
cord-277417-f71jwdzj	241	23	whether	whether	IN
cord-277417-f71jwdzj	241	24	these	these	DT
cord-277417-f71jwdzj	241	25	affect	affect	VBP
cord-277417-f71jwdzj	241	26	host	host	NN
cord-277417-f71jwdzj	241	27	range	range	NN
cord-277417-f71jwdzj	241	28	alone	alone	RB
cord-277417-f71jwdzj	241	29	,	,	,
cord-277417-f71jwdzj	241	30	or	or	CC
cord-277417-f71jwdzj	241	31	both	both	DT
cord-277417-f71jwdzj	241	32	host	host	NN
cord-277417-f71jwdzj	241	33	range	range	NN
cord-277417-f71jwdzj	241	34	and	and	CC
cord-277417-f71jwdzj	241	35	virulence	virulence	NN
cord-277417-f71jwdzj	241	36	,	,	,
cord-277417-f71jwdzj	241	37	is	be	VBZ
cord-277417-f71jwdzj	241	38	unclear	unclear	JJ
cord-277417-f71jwdzj	241	39	66	66	CD
cord-277417-f71jwdzj	241	40	,	,	,
cord-277417-f71jwdzj	241	41	84	84	CD
cord-277417-f71jwdzj	241	42	.	.	.
cord-277417-f71jwdzj	242	1	The	the	DT
cord-277417-f71jwdzj	242	2	canonical	canonical	JJ
cord-277417-f71jwdzj	242	3	study	study	NN
cord-277417-f71jwdzj	242	4	of	of	IN
cord-277417-f71jwdzj	242	5	virulence	virulence	NN
cord-277417-f71jwdzj	242	6	evolution	evolution	NN
cord-277417-f71jwdzj	242	7	following	follow	VBG
cord-277417-f71jwdzj	242	8	a	a	DT
cord-277417-f71jwdzj	242	9	species	species	NN
cord-277417-f71jwdzj	242	10	jump	jump	NN
cord-277417-f71jwdzj	242	11	is	be	VBZ
cord-277417-f71jwdzj	242	12	MYXV	MYXV	NNP
cord-277417-f71jwdzj	242	13	in	in	IN
cord-277417-f71jwdzj	242	14	European	european	JJ
cord-277417-f71jwdzj	242	15	rabbits	rabbit	NNS
cord-277417-f71jwdzj	242	16	,	,	,
cord-277417-f71jwdzj	242	17	with	with	IN
cord-277417-f71jwdzj	242	18	a	a	DT
cord-277417-f71jwdzj	242	19	body	body	NN
cord-277417-f71jwdzj	242	20	of	of	IN
cord-277417-f71jwdzj	242	21	classic	classic	JJ
cord-277417-f71jwdzj	242	22	work	work	NN
cord-277417-f71jwdzj	242	23	undertaken	undertake	VBN
cord-277417-f71jwdzj	242	24	by	by	IN
cord-277417-f71jwdzj	242	25	Fenner	Fenner	NNP
cord-277417-f71jwdzj	242	26	and	and	CC
cord-277417-f71jwdzj	242	27	colleagues	colleague	NNS
cord-277417-f71jwdzj	242	28	91	91	CD
cord-277417-f71jwdzj	242	29	-	-	HYPH
cord-277417-f71jwdzj	242	30	93	93	CD
cord-277417-f71jwdzj	242	31	(	(	-LRB-
cord-277417-f71jwdzj	242	32	box	box	NN
cord-277417-f71jwdzj	242	33	2	2	CD
cord-277417-f71jwdzj	242	34	)	)	-RRB-
cord-277417-f71jwdzj	242	35	.	.	.
cord-277417-f71jwdzj	243	1	In	in	IN
cord-277417-f71jwdzj	243	2	both	both	DT
cord-277417-f71jwdzj	243	3	Australia	Australia	NNP
cord-277417-f71jwdzj	243	4	and	and	CC
cord-277417-f71jwdzj	243	5	Europe	Europe	NNP
cord-277417-f71jwdzj	243	6	,	,	,
cord-277417-f71jwdzj	243	7	highly	highly	RB
cord-277417-f71jwdzj	243	8	virulent	virulent	JJ
cord-277417-f71jwdzj	243	9	strains	strain	NNS
cord-277417-f71jwdzj	243	10	of	of	IN
cord-277417-f71jwdzj	243	11	MYXV	MYXV	NNP
cord-277417-f71jwdzj	243	12	were	be	VBD
cord-277417-f71jwdzj	243	13	used	use	VBN
cord-277417-f71jwdzj	243	14	as	as	IN
cord-277417-f71jwdzj	243	15	a	a	DT
cord-277417-f71jwdzj	243	16	biological	biological	JJ
cord-277417-f71jwdzj	243	17	control	control	NN
cord-277417-f71jwdzj	243	18	against	against	IN
cord-277417-f71jwdzj	243	19	the	the	DT
cord-277417-f71jwdzj	243	20	European	european	JJ
cord-277417-f71jwdzj	243	21	rabbit	rabbit	NN
cord-277417-f71jwdzj	243	22	population	population	NN
cord-277417-f71jwdzj	243	23	,	,	,
cord-277417-f71jwdzj	243	24	with	with	IN
cord-277417-f71jwdzj	243	25	releases	release	NNS
cord-277417-f71jwdzj	243	26	beginning	begin	VBG
cord-277417-f71jwdzj	243	27	in	in	IN
cord-277417-f71jwdzj	243	28	the	the	DT
cord-277417-f71jwdzj	243	29	early	early	JJ
cord-277417-f71jwdzj	243	30	1950s	1950	NNS
cord-277417-f71jwdzj	243	31	.	.	.
cord-277417-f71jwdzj	244	1	In	in	IN
cord-277417-f71jwdzj	244	2	both	both	DT
cord-277417-f71jwdzj	244	3	continents	continent	NNS
cord-277417-f71jwdzj	244	4	,	,	,
cord-277417-f71jwdzj	244	5	the	the	DT
cord-277417-f71jwdzj	244	6	same	same	JJ
cord-277417-f71jwdzj	244	7	trajectory	trajectory	NN
cord-277417-f71jwdzj	244	8	of	of	IN
cord-277417-f71jwdzj	244	9	virulence	virulence	NN
cord-277417-f71jwdzj	244	10	evolution	evolution	NN
cord-277417-f71jwdzj	244	11	was	be	VBD
cord-277417-f71jwdzj	244	12	observed	observe	VBN
cord-277417-f71jwdzj	244	13	:	:	:
cord-277417-f71jwdzj	244	14	virulence	virulence	NN
cord-277417-f71jwdzj	244	15	declined	decline	VBD
cord-277417-f71jwdzj	244	16	from	from	IN
cord-277417-f71jwdzj	244	17	the	the	DT
cord-277417-f71jwdzj	244	18	highly	highly	RB
cord-277417-f71jwdzj	244	19	virulent	virulent	JJ
cord-277417-f71jwdzj	245	1	(	(	-LRB-
cord-277417-f71jwdzj	245	2	that	that	DT
cord-277417-f71jwdzj	245	3	is	is	RB
cord-277417-f71jwdzj	245	4	,	,	,
cord-277417-f71jwdzj	245	5	grade	grade	NN
cord-277417-f71jwdzj	245	6	I	I	NNP
cord-277417-f71jwdzj	245	7	)	)	-RRB-
cord-277417-f71jwdzj	245	8	release	release	VBP
cord-277417-f71jwdzj	245	9	strains	strain	NNS
cord-277417-f71jwdzj	245	10	to	to	TO
cord-277417-f71jwdzj	245	11	encompass	encompass	VB
cord-277417-f71jwdzj	245	12	a	a	DT
cord-277417-f71jwdzj	245	13	far	far	RB
cord-277417-f71jwdzj	245	14	wider	wide	JJR
cord-277417-f71jwdzj	245	15	range	range	NN
cord-277417-f71jwdzj	245	16	of	of	IN
cord-277417-f71jwdzj	245	17	virulence	virulence	NN
cord-277417-f71jwdzj	245	18	grades	grade	NNS
cord-277417-f71jwdzj	245	19	,	,	,
cord-277417-f71jwdzj	245	20	including	include	VBG
cord-277417-f71jwdzj	245	21	the	the	DT
cord-277417-f71jwdzj	245	22	most	most	RBS
cord-277417-f71jwdzj	245	23	attenuated	attenuated	JJ
cord-277417-f71jwdzj	245	24	grade	grade	NN
cord-277417-f71jwdzj	245	25	V	v	NN
cord-277417-f71jwdzj	245	26	strains	strain	NNS
cord-277417-f71jwdzj	245	27	,	,	,
cord-277417-f71jwdzj	245	28	with	with	IN
cord-277417-f71jwdzj	245	29	strains	strain	NNS
cord-277417-f71jwdzj	245	30	of	of	IN
cord-277417-f71jwdzj	245	31	'	'	``
cord-277417-f71jwdzj	245	32	intermediate	intermediate	JJ
cord-277417-f71jwdzj	245	33	'	'	''
cord-277417-f71jwdzj	245	34	virulence	virulence	NN
cord-277417-f71jwdzj	245	35	the	the	DT
cord-277417-f71jwdzj	245	36	most	most	RBS
cord-277417-f71jwdzj	245	37	commonly	commonly	RB
cord-277417-f71jwdzj	245	38	sampled	sample	VBN
cord-277417-f71jwdzj	245	39	in	in	IN
cord-277417-f71jwdzj	245	40	the	the	DT
cord-277417-f71jwdzj	245	41	field	field	NN
cord-277417-f71jwdzj	245	42	.	.	.
cord-277417-f71jwdzj	246	1	This	this	DT
cord-277417-f71jwdzj	246	2	pattern	pattern	NN
cord-277417-f71jwdzj	246	3	,	,	,
cord-277417-f71jwdzj	246	4	reflecting	reflect	VBG
cord-277417-f71jwdzj	246	5	a	a	DT
cord-277417-f71jwdzj	246	6	combination	combination	NN
cord-277417-f71jwdzj	246	7	of	of	IN
cord-277417-f71jwdzj	246	8	the	the	DT
cord-277417-f71jwdzj	246	9	virus	virus	NN
cord-277417-f71jwdzj	246	10	evolving	evolve	VBG
cord-277417-f71jwdzj	246	11	more	more	RBR
cord-277417-f71jwdzj	246	12	attenuated	attenuated	JJ
cord-277417-f71jwdzj	246	13	strains	strain	NNS
cord-277417-f71jwdzj	246	14	and	and	CC
cord-277417-f71jwdzj	246	15	the	the	DT
cord-277417-f71jwdzj	246	16	host	host	NN
cord-277417-f71jwdzj	246	17	developing	develop	VBG
cord-277417-f71jwdzj	246	18	resistance	resistance	NN
cord-277417-f71jwdzj	246	19	,	,	,
cord-277417-f71jwdzj	246	20	fuelled	fuel	VBD
cord-277417-f71jwdzj	246	21	the	the	DT
cord-277417-f71jwdzj	246	22	idea	idea	NN
cord-277417-f71jwdzj	246	23	of	of	IN
cord-277417-f71jwdzj	246	24	a	a	DT
cord-277417-f71jwdzj	246	25	trade	trade	NN
cord-277417-f71jwdzj	246	26	-	-	HYPH
cord-277417-f71jwdzj	246	27	off	off	NN
cord-277417-f71jwdzj	246	28	between	between	IN
cord-277417-f71jwdzj	246	29	virulence	virulence	NN
cord-277417-f71jwdzj	246	30	and	and	CC
cord-277417-f71jwdzj	246	31	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	246	32	.	.	.
cord-277417-f71jwdzj	247	1	Sixty	sixty	CD
cord-277417-f71jwdzj	247	2	years	year	NNS
cord-277417-f71jwdzj	247	3	after	after	IN
cord-277417-f71jwdzj	247	4	the	the	DT
cord-277417-f71jwdzj	247	5	initial	initial	JJ
cord-277417-f71jwdzj	247	6	release	release	NN
cord-277417-f71jwdzj	247	7	of	of	IN
cord-277417-f71jwdzj	247	8	MYXV	MYXV	NNP
cord-277417-f71jwdzj	247	9	,	,	,
cord-277417-f71jwdzj	247	10	the	the	DT
cord-277417-f71jwdzj	247	11	first	first	JJ
cord-277417-f71jwdzj	247	12	large	large	JJ
cord-277417-f71jwdzj	247	13	-	-	HYPH
cord-277417-f71jwdzj	247	14	scale	scale	NN
cord-277417-f71jwdzj	247	15	genomic	genomic	JJ
cord-277417-f71jwdzj	247	16	studies	study	NNS
cord-277417-f71jwdzj	247	17	of	of	IN
cord-277417-f71jwdzj	247	18	its	-PRON-	PRP$
cord-277417-f71jwdzj	247	19	spread	spread	NN
cord-277417-f71jwdzj	247	20	were	be	VBD
cord-277417-f71jwdzj	247	21	performed	perform	VBN
cord-277417-f71jwdzj	247	22	(	(	-LRB-
cord-277417-f71jwdzj	247	23	box	box	NN
cord-277417-f71jwdzj	247	24	2	2	CD
cord-277417-f71jwdzj	247	25	)	)	-RRB-
cord-277417-f71jwdzj	247	26	.	.	.
cord-277417-f71jwdzj	248	1	Phylogenomic	Phylogenomic	NNP
cord-277417-f71jwdzj	248	2	analysis	analysis	NN
cord-277417-f71jwdzj	248	3	revealed	reveal	VBD
cord-277417-f71jwdzj	248	4	that	that	IN
cord-277417-f71jwdzj	248	5	the	the	DT
cord-277417-f71jwdzj	248	6	virulence	virulence	NN
cord-277417-f71jwdzj	248	7	phenotype	phenotype	NN
cord-277417-f71jwdzj	248	8	has	have	VBZ
cord-277417-f71jwdzj	248	9	changed	change	VBN
cord-277417-f71jwdzj	248	10	on	on	IN
cord-277417-f71jwdzj	248	11	a	a	DT
cord-277417-f71jwdzj	248	12	regular	regular	JJ
cord-277417-f71jwdzj	248	13	basis	basis	NN
cord-277417-f71jwdzj	248	14	94	94	CD
cord-277417-f71jwdzj	248	15	.	.	.
cord-277417-f71jwdzj	249	1	However	however	RB
cord-277417-f71jwdzj	249	2	,	,	,
cord-277417-f71jwdzj	249	3	a	a	DT
cord-277417-f71jwdzj	249	4	major	major	JJ
cord-277417-f71jwdzj	249	5	surprise	surprise	NN
cord-277417-f71jwdzj	249	6	was	be	VBD
cord-277417-f71jwdzj	249	7	that	that	IN
cord-277417-f71jwdzj	249	8	each	each	DT
cord-277417-f71jwdzj	249	9	change	change	NN
cord-277417-f71jwdzj	249	10	in	in	IN
cord-277417-f71jwdzj	249	11	virulence	virulence	NN
cord-277417-f71jwdzj	249	12	was	be	VBD
cord-277417-f71jwdzj	249	13	associated	associate	VBN
cord-277417-f71jwdzj	249	14	with	with	IN
cord-277417-f71jwdzj	249	15	a	a	DT
cord-277417-f71jwdzj	249	16	different	different	JJ
cord-277417-f71jwdzj	249	17	set	set	NN
cord-277417-f71jwdzj	249	18	of	of	IN
cord-277417-f71jwdzj	249	19	mutations	mutation	NNS
cord-277417-f71jwdzj	249	20	across	across	IN
cord-277417-f71jwdzj	249	21	multiple	multiple	JJ
cord-277417-f71jwdzj	249	22	genes	gene	NNS
cord-277417-f71jwdzj	249	23	94	94	CD
cord-277417-f71jwdzj	249	24	,	,	,
cord-277417-f71jwdzj	249	25	95	95	CD
cord-277417-f71jwdzj	249	26	.	.	.
cord-277417-f71jwdzj	250	1	Although	although	IN
cord-277417-f71jwdzj	250	2	which	which	WDT
cord-277417-f71jwdzj	250	3	mutations	mutation	NNS
cord-277417-f71jwdzj	250	4	had	have	VBD
cord-277417-f71jwdzj	250	5	the	the	DT
cord-277417-f71jwdzj	250	6	greatest	great	JJS
cord-277417-f71jwdzj	250	7	impact	impact	NN
cord-277417-f71jwdzj	250	8	on	on	IN
cord-277417-f71jwdzj	250	9	virulence	virulence	NN
cord-277417-f71jwdzj	250	10	is	be	VBZ
cord-277417-f71jwdzj	250	11	still	still	RB
cord-277417-f71jwdzj	250	12	unclear	unclear	JJ
cord-277417-f71jwdzj	250	13	and	and	CC
cord-277417-f71jwdzj	250	14	requires	require	VBZ
cord-277417-f71jwdzj	250	15	further	further	JJ
cord-277417-f71jwdzj	250	16	experimental	experimental	JJ
cord-277417-f71jwdzj	250	17	analysis	analysis	NN
cord-277417-f71jwdzj	250	18	,	,	,
cord-277417-f71jwdzj	250	19	such	such	PDT
cord-277417-f71jwdzj	250	20	a	a	DT
cord-277417-f71jwdzj	250	21	phylogenomic	phylogenomic	JJ
cord-277417-f71jwdzj	250	22	pattern	pattern	NN
cord-277417-f71jwdzj	250	23	indicates	indicate	VBZ
cord-277417-f71jwdzj	250	24	that	that	IN
cord-277417-f71jwdzj	250	25	there	there	EX
cord-277417-f71jwdzj	250	26	are	be	VBP
cord-277417-f71jwdzj	250	27	multiple	multiple	JJ
cord-277417-f71jwdzj	250	28	routes	route	NNS
cord-277417-f71jwdzj	250	29	to	to	IN
cord-277417-f71jwdzj	250	30	achieving	achieve	VBG
cord-277417-f71jwdzj	250	31	the	the	DT
cord-277417-f71jwdzj	250	32	same	same	JJ
cord-277417-f71jwdzj	250	33	levels	level	NNS
cord-277417-f71jwdzj	250	34	of	of	IN
cord-277417-f71jwdzj	250	35	virulence	virulence	NN
cord-277417-f71jwdzj	250	36	,	,	,
cord-277417-f71jwdzj	250	37	including	include	VBG
cord-277417-f71jwdzj	250	38	attenuation	attenuation	NN
cord-277417-f71jwdzj	250	39	,	,	,
cord-277417-f71jwdzj	250	40	such	such	JJ
cord-277417-f71jwdzj	250	41	that	that	IN
cord-277417-f71jwdzj	250	42	there	there	EX
cord-277417-f71jwdzj	250	43	has	have	VBZ
cord-277417-f71jwdzj	250	44	been	be	VBN
cord-277417-f71jwdzj	250	45	convergent	convergent	JJ
cord-277417-f71jwdzj	250	46	evolution	evolution	NN
cord-277417-f71jwdzj	250	47	for	for	IN
cord-277417-f71jwdzj	250	48	phenotype	phenotype	NN
cord-277417-f71jwdzj	250	49	but	but	CC
cord-277417-f71jwdzj	250	50	not	not	RB
cord-277417-f71jwdzj	250	51	genotype	genotype	NN
cord-277417-f71jwdzj	250	52	.	.	.
cord-277417-f71jwdzj	251	1	It	-PRON-	PRP
cord-277417-f71jwdzj	251	2	is	be	VBZ
cord-277417-f71jwdzj	251	3	likely	likely	JJ
cord-277417-f71jwdzj	251	4	that	that	IN
cord-277417-f71jwdzj	251	5	this	this	DT
cord-277417-f71jwdzj	251	6	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	251	7	flexibility	flexibility	NN
cord-277417-f71jwdzj	251	8	in	in	IN
cord-277417-f71jwdzj	251	9	part	part	NN
cord-277417-f71jwdzj	251	10	reflects	reflect	VBZ
cord-277417-f71jwdzj	251	11	the	the	DT
cord-277417-f71jwdzj	251	12	fairly	fairly	RB
cord-277417-f71jwdzj	251	13	large	large	JJ
cord-277417-f71jwdzj	251	14	genome	genome	NN
cord-277417-f71jwdzj	251	15	size	size	NN
cord-277417-f71jwdzj	251	16	of	of	IN
cord-277417-f71jwdzj	251	17	MYXV	MYXV	NNP
cord-277417-f71jwdzj	251	18	(	(	-LRB-
cord-277417-f71jwdzj	251	19	a	a	DT
cord-277417-f71jwdzj	251	20	double	double	RB
cord-277417-f71jwdzj	251	21	-	-	HYPH
cord-277417-f71jwdzj	251	22	stranded	stranded	JJ
cord-277417-f71jwdzj	251	23	DNA	dna	NN
cord-277417-f71jwdzj	251	24	virus	virus	NN
cord-277417-f71jwdzj	251	25	of	of	IN
cord-277417-f71jwdzj	251	26	~160,000	~160,000	CD
cord-277417-f71jwdzj	251	27	bp	bp	NNP
cord-277417-f71jwdzj	251	28	)	)	-RRB-
cord-277417-f71jwdzj	251	29	,	,	,
cord-277417-f71jwdzj	251	30	which	which	WDT
cord-277417-f71jwdzj	251	31	may	may	MD
cord-277417-f71jwdzj	251	32	mean	mean	VB
cord-277417-f71jwdzj	251	33	that	that	IN
cord-277417-f71jwdzj	251	34	there	there	EX
cord-277417-f71jwdzj	251	35	is	be	VBZ
cord-277417-f71jwdzj	251	36	a	a	DT
cord-277417-f71jwdzj	251	37	large	large	JJ
cord-277417-f71jwdzj	251	38	number	number	NN
cord-277417-f71jwdzj	251	39	of	of	IN
cord-277417-f71jwdzj	251	40	potential	potential	JJ
cord-277417-f71jwdzj	251	41	virulence	virulence	NN
cord-277417-f71jwdzj	251	42	determinants	determinant	NNS
cord-277417-f71jwdzj	251	43	that	that	WDT
cord-277417-f71jwdzj	251	44	can	can	MD
cord-277417-f71jwdzj	251	45	interact	interact	VB
cord-277417-f71jwdzj	251	46	through	through	IN
cord-277417-f71jwdzj	251	47	epistasis	epistasis	NN
cord-277417-f71jwdzj	251	48	96	96	CD
cord-277417-f71jwdzj	251	49	,	,	,
cord-277417-f71jwdzj	251	50	in	in	IN
cord-277417-f71jwdzj	251	51	turn	turn	NN
cord-277417-f71jwdzj	251	52	complicating	complicate	VBG
cord-277417-f71jwdzj	251	53	any	any	DT
cord-277417-f71jwdzj	251	54	phylogenomic	phylogenomic	NNP
cord-277417-f71jwdzj	251	55	analysis	analysis	NN
cord-277417-f71jwdzj	251	56	.	.	.
cord-277417-f71jwdzj	252	1	Marek	Marek	NNP
cord-277417-f71jwdzj	252	2	's	's	POS
cord-277417-f71jwdzj	252	3	disease	disease	NN
cord-277417-f71jwdzj	252	4	virus	virus	NN
cord-277417-f71jwdzj	252	5	.	.	.
cord-277417-f71jwdzj	253	1	Whether	whether	IN
cord-277417-f71jwdzj	253	2	'	'	``
cord-277417-f71jwdzj	253	3	imperfect	imperfect	JJ
cord-277417-f71jwdzj	253	4	'	'	''
cord-277417-f71jwdzj	253	5	(	(	-LRB-
cord-277417-f71jwdzj	253	6	that	that	RB
cord-277417-f71jwdzj	253	7	is	is	RB
cord-277417-f71jwdzj	253	8	,	,	,
cord-277417-f71jwdzj	253	9	'	'	``
cord-277417-f71jwdzj	253	10	leaky	leaky	JJ
cord-277417-f71jwdzj	253	11	'	'	''
cord-277417-f71jwdzj	253	12	)	)	-RRB-
cord-277417-f71jwdzj	253	13	vaccination	vaccination	NN
cord-277417-f71jwdzj	253	14	against	against	IN
cord-277417-f71jwdzj	253	15	infectious	infectious	JJ
cord-277417-f71jwdzj	253	16	disease	disease	NN
cord-277417-f71jwdzj	253	17	,	,	,
cord-277417-f71jwdzj	253	18	in	in	IN
cord-277417-f71jwdzj	253	19	which	which	WDT
cord-277417-f71jwdzj	253	20	disease	disease	NN
cord-277417-f71jwdzj	253	21	symptoms	symptom	NNS
cord-277417-f71jwdzj	253	22	are	be	VBP
cord-277417-f71jwdzj	253	23	reduced	reduce	VBN
cord-277417-f71jwdzj	253	24	but	but	CC
cord-277417-f71jwdzj	253	25	there	there	EX
cord-277417-f71jwdzj	253	26	is	be	VBZ
cord-277417-f71jwdzj	253	27	less	less	JJR
cord-277417-f71jwdzj	253	28	impact	impact	NN
cord-277417-f71jwdzj	253	29	on	on	IN
cord-277417-f71jwdzj	253	30	virus	virus	NN
cord-277417-f71jwdzj	253	31	replication	replication	NN
cord-277417-f71jwdzj	253	32	and	and	CC
cord-277417-f71jwdzj	253	33	transmission	transmission	NN
cord-277417-f71jwdzj	253	34	,	,	,
cord-277417-f71jwdzj	253	35	will	will	MD
cord-277417-f71jwdzj	253	36	change	change	VB
cord-277417-f71jwdzj	253	37	the	the	DT
cord-277417-f71jwdzj	253	38	selection	selection	NN
cord-277417-f71jwdzj	253	39	pressures	pressure	NNS
cord-277417-f71jwdzj	253	40	acting	act	VBG
cord-277417-f71jwdzj	253	41	on	on	IN
cord-277417-f71jwdzj	253	42	the	the	DT
cord-277417-f71jwdzj	253	43	pathogen	pathogen	NN
cord-277417-f71jwdzj	253	44	and	and	CC
cord-277417-f71jwdzj	253	45	affect	affect	VB
cord-277417-f71jwdzj	253	46	virulence	virulence	NN
cord-277417-f71jwdzj	253	47	evolution	evolution	NN
cord-277417-f71jwdzj	253	48	has	have	VBZ
cord-277417-f71jwdzj	253	49	been	be	VBN
cord-277417-f71jwdzj	253	50	the	the	DT
cord-277417-f71jwdzj	253	51	source	source	NN
cord-277417-f71jwdzj	253	52	of	of	IN
cord-277417-f71jwdzj	253	53	debate	debate	NN
cord-277417-f71jwdzj	253	54	97	97	CD
cord-277417-f71jwdzj	253	55	,	,	,
cord-277417-f71jwdzj	253	56	98	98	CD
cord-277417-f71jwdzj	253	57	.	.	.
cord-277417-f71jwdzj	254	1	Although	although	IN
cord-277417-f71jwdzj	254	2	still	still	RB
cord-277417-f71jwdzj	254	3	contentious	contentious	JJ
cord-277417-f71jwdzj	254	4	,	,	,
cord-277417-f71jwdzj	254	5	particularly	particularly	RB
cord-277417-f71jwdzj	254	6	in	in	IN
cord-277417-f71jwdzj	254	7	the	the	DT
cord-277417-f71jwdzj	254	8	case	case	NN
cord-277417-f71jwdzj	254	9	of	of	IN
cord-277417-f71jwdzj	254	10	human	human	JJ
cord-277417-f71jwdzj	254	11	disease	disease	NN
cord-277417-f71jwdzj	254	12	,	,	,
cord-277417-f71jwdzj	254	13	there	there	EX
cord-277417-f71jwdzj	254	14	is	be	VBZ
cord-277417-f71jwdzj	254	15	good	good	JJ
cord-277417-f71jwdzj	254	16	evidence	evidence	NN
cord-277417-f71jwdzj	254	17	that	that	IN
cord-277417-f71jwdzj	254	18	imperfect	imperfect	JJ
cord-277417-f71jwdzj	254	19	vaccination	vaccination	NN
cord-277417-f71jwdzj	254	20	has	have	VBZ
cord-277417-f71jwdzj	254	21	increased	increase	VBN
cord-277417-f71jwdzj	254	22	virulence	virulence	NN
cord-277417-f71jwdzj	254	23	in	in	IN
cord-277417-f71jwdzj	254	24	the	the	DT
cord-277417-f71jwdzj	254	25	case	case	NN
cord-277417-f71jwdzj	254	26	of	of	IN
cord-277417-f71jwdzj	254	27	MDV	MDV	NNP
cord-277417-f71jwdzj	254	28	,	,	,
cord-277417-f71jwdzj	254	29	a	a	DT
cord-277417-f71jwdzj	254	30	DNA	dna	NN
cord-277417-f71jwdzj	254	31	herpesvirus	herpesvirus	NN
cord-277417-f71jwdzj	254	32	that	that	WDT
cord-277417-f71jwdzj	254	33	poses	pose	VBZ
cord-277417-f71jwdzj	254	34	a	a	DT
cord-277417-f71jwdzj	254	35	major	major	JJ
cord-277417-f71jwdzj	254	36	problem	problem	NN
cord-277417-f71jwdzj	254	37	to	to	IN
cord-277417-f71jwdzj	254	38	the	the	DT
cord-277417-f71jwdzj	254	39	poultry	poultry	NN
cord-277417-f71jwdzj	254	40	industry	industry	NN
cord-277417-f71jwdzj	254	41	99	99	CD
cord-277417-f71jwdzj	254	42	.	.	.
cord-277417-f71jwdzj	255	1	In	in	IN
cord-277417-f71jwdzj	255	2	the	the	DT
cord-277417-f71jwdzj	255	3	1960s	1960	NNS
cord-277417-f71jwdzj	255	4	,	,	,
cord-277417-f71jwdzj	255	5	the	the	DT
cord-277417-f71jwdzj	255	6	appearance	appearance	NN
cord-277417-f71jwdzj	255	7	of	of	IN
cord-277417-f71jwdzj	255	8	virulent	virulent	JJ
cord-277417-f71jwdzj	255	9	MDV	MDV	NNP
cord-277417-f71jwdzj	255	10	strains	strain	NNS
cord-277417-f71jwdzj	255	11	forced	force	VBD
cord-277417-f71jwdzj	255	12	the	the	DT
cord-277417-f71jwdzj	255	13	development	development	NN
cord-277417-f71jwdzj	255	14	of	of	IN
cord-277417-f71jwdzj	255	15	the	the	DT
cord-277417-f71jwdzj	255	16	first	first	JJ
cord-277417-f71jwdzj	255	17	generation	generation	NN
cord-277417-f71jwdzj	255	18	of	of	IN
cord-277417-f71jwdzj	255	19	Marek	Marek	NNP
cord-277417-f71jwdzj	255	20	's	's	POS
cord-277417-f71jwdzj	255	21	disease	disease	NN
cord-277417-f71jwdzj	255	22	vaccines	vaccine	NNS
cord-277417-f71jwdzj	255	23	.	.	.
cord-277417-f71jwdzj	256	1	However	however	RB
cord-277417-f71jwdzj	256	2	,	,	,
cord-277417-f71jwdzj	256	3	because	because	IN
cord-277417-f71jwdzj	256	4	these	these	DT
cord-277417-f71jwdzj	256	5	vaccines	vaccine	NNS
cord-277417-f71jwdzj	256	6	were	be	VBD
cord-277417-f71jwdzj	256	7	imperfect	imperfect	JJ
cord-277417-f71jwdzj	256	8	,	,	,
cord-277417-f71jwdzj	256	9	'	'	''
cord-277417-f71jwdzj	256	10	very	very	RB
cord-277417-f71jwdzj	256	11	virulent	virulent	JJ
cord-277417-f71jwdzj	256	12	'	'	''
cord-277417-f71jwdzj	256	13	MDV	mdv	NN
cord-277417-f71jwdzj	256	14	began	begin	VBD
cord-277417-f71jwdzj	256	15	to	to	TO
cord-277417-f71jwdzj	256	16	appear	appear	VB
cord-277417-f71jwdzj	256	17	within	within	IN
cord-277417-f71jwdzj	256	18	10	10	CD
cord-277417-f71jwdzj	256	19	years	year	NNS
cord-277417-f71jwdzj	256	20	,	,	,
cord-277417-f71jwdzj	256	21	necessitating	necessitate	VBG
cord-277417-f71jwdzj	256	22	a	a	DT
cord-277417-f71jwdzj	256	23	second	second	JJ
cord-277417-f71jwdzj	256	24	-	-	HYPH
cord-277417-f71jwdzj	256	25	generation	generation	NN
cord-277417-f71jwdzj	256	26	vaccine	vaccine	NN
cord-277417-f71jwdzj	256	27	.	.	.
cord-277417-f71jwdzj	257	1	This	this	DT
cord-277417-f71jwdzj	257	2	very	very	RB
cord-277417-f71jwdzj	257	3	virulent	virulent	JJ
cord-277417-f71jwdzj	257	4	MDV	mdv	NN
cord-277417-f71jwdzj	257	5	was	be	VBD
cord-277417-f71jwdzj	257	6	followed	follow	VBN
cord-277417-f71jwdzj	257	7	,	,	,
cord-277417-f71jwdzj	257	8	more	more	RBR
cord-277417-f71jwdzj	257	9	rapidly	rapidly	RB
cord-277417-f71jwdzj	257	10	,	,	,
cord-277417-f71jwdzj	257	11	by	by	IN
cord-277417-f71jwdzj	257	12	the	the	DT
cord-277417-f71jwdzj	257	13	appearance	appearance	NN
cord-277417-f71jwdzj	257	14	of	of	IN
cord-277417-f71jwdzj	257	15	'	'	``
cord-277417-f71jwdzj	257	16	very	very	RB
cord-277417-f71jwdzj	257	17	virulent	virulent	JJ
cord-277417-f71jwdzj	257	18	plus	plus	CC
cord-277417-f71jwdzj	257	19	'	'	''
cord-277417-f71jwdzj	257	20	MDV	mdv	NN
cord-277417-f71jwdzj	257	21	,	,	,
cord-277417-f71jwdzj	257	22	requiring	require	VBG
cord-277417-f71jwdzj	257	23	a	a	DT
cord-277417-f71jwdzj	257	24	third	third	JJ
cord-277417-f71jwdzj	257	25	-	-	HYPH
cord-277417-f71jwdzj	257	26	generation	generation	NN
cord-277417-f71jwdzj	257	27	vaccine	vaccine	NN
cord-277417-f71jwdzj	257	28	(	(	-LRB-
cord-277417-f71jwdzj	257	29	FIg	FIg	NNS
cord-277417-f71jwdzj	257	30	.	.	.
cord-277417-f71jwdzj	258	1	3	3	LS
cord-277417-f71jwdzj	258	2	)	)	-RRB-
cord-277417-f71jwdzj	258	3	.	.	.
cord-277417-f71jwdzj	259	1	Imperfect	imperfect	JJ
cord-277417-f71jwdzj	259	2	MDV	MDV	NNP
cord-277417-f71jwdzj	259	3	vaccines	vaccine	NNS
cord-277417-f71jwdzj	259	4	enhance	enhance	VBP
cord-277417-f71jwdzj	259	5	virulence	virulence	NN
cord-277417-f71jwdzj	259	6	by	by	IN
cord-277417-f71jwdzj	259	7	elongating	elongate	VBG
cord-277417-f71jwdzj	259	8	the	the	DT
cord-277417-f71jwdzj	259	9	infectious	infectious	JJ
cord-277417-f71jwdzj	259	10	periods	period	NNS
cord-277417-f71jwdzj	259	11	and	and	CC
cord-277417-f71jwdzj	259	12	hence	hence	RB
cord-277417-f71jwdzj	259	13	transmission	transmission	NN
cord-277417-f71jwdzj	259	14	potential	potential	NN
cord-277417-f71jwdzj	259	15	of	of	IN
cord-277417-f71jwdzj	259	16	virulent	virulent	JJ
cord-277417-f71jwdzj	259	17	strains	strain	NNS
cord-277417-f71jwdzj	259	18	that	that	WDT
cord-277417-f71jwdzj	259	19	would	would	MD
cord-277417-f71jwdzj	259	20	have	have	VB
cord-277417-f71jwdzj	259	21	been	be	VBN
cord-277417-f71jwdzj	259	22	removed	remove	VBN
cord-277417-f71jwdzj	259	23	by	by	IN
cord-277417-f71jwdzj	259	24	natural	natural	JJ
cord-277417-f71jwdzj	259	25	selection	selection	NN
cord-277417-f71jwdzj	259	26	before	before	IN
cord-277417-f71jwdzj	259	27	transmission	transmission	NN
cord-277417-f71jwdzj	259	28	in	in	IN
cord-277417-f71jwdzj	259	29	the	the	DT
cord-277417-f71jwdzj	259	30	absence	absence	NN
cord-277417-f71jwdzj	259	31	of	of	IN
cord-277417-f71jwdzj	259	32	vaccination	vaccination	NN
cord-277417-f71jwdzj	259	33	99	99	CD
cord-277417-f71jwdzj	259	34	.	.	.
cord-277417-f71jwdzj	260	1	Although	although	IN
cord-277417-f71jwdzj	260	2	the	the	DT
cord-277417-f71jwdzj	260	3	genomic	genomic	JJ
cord-277417-f71jwdzj	260	4	basis	basis	NN
cord-277417-f71jwdzj	260	5	to	to	IN
cord-277417-f71jwdzj	260	6	MDV	MDV	NNP
cord-277417-f71jwdzj	260	7	virulence	virulence	NN
cord-277417-f71jwdzj	260	8	evolution	evolution	NN
cord-277417-f71jwdzj	260	9	is	be	VBZ
cord-277417-f71jwdzj	260	10	currently	currently	RB
cord-277417-f71jwdzj	260	11	uncertain	uncertain	JJ
cord-277417-f71jwdzj	260	12	,	,	,
cord-277417-f71jwdzj	260	13	with	with	IN
cord-277417-f71jwdzj	260	14	some	some	DT
cord-277417-f71jwdzj	260	15	causative	causative	JJ
cord-277417-f71jwdzj	260	16	amino	amino	NN
cord-277417-f71jwdzj	260	17	acid	acid	NN
cord-277417-f71jwdzj	260	18	changes	change	NNS
cord-277417-f71jwdzj	260	19	proposed	propose	VBD
cord-277417-f71jwdzj	260	20	100	100	CD
cord-277417-f71jwdzj	260	21	,	,	,
cord-277417-f71jwdzj	260	22	initial	initial	JJ
cord-277417-f71jwdzj	260	23	phylogenomic	phylogenomic	NNP
cord-277417-f71jwdzj	260	24	studies	study	NNS
cord-277417-f71jwdzj	260	25	suggest	suggest	VBP
cord-277417-f71jwdzj	260	26	that	that	IN
cord-277417-f71jwdzj	260	27	,	,	,
cord-277417-f71jwdzj	260	28	as	as	IN
cord-277417-f71jwdzj	260	29	in	in	IN
cord-277417-f71jwdzj	260	30	the	the	DT
cord-277417-f71jwdzj	260	31	case	case	NN
cord-277417-f71jwdzj	260	32	of	of	IN
cord-277417-f71jwdzj	260	33	MYXV	MYXV	NNP
cord-277417-f71jwdzj	260	34	,	,	,
cord-277417-f71jwdzj	260	35	there	there	EX
cord-277417-f71jwdzj	260	36	are	be	VBP
cord-277417-f71jwdzj	260	37	multiple	multiple	JJ
cord-277417-f71jwdzj	260	38	genetic	genetic	JJ
cord-277417-f71jwdzj	260	39	pathways	pathway	NNS
cord-277417-f71jwdzj	260	40	to	to	IN
cord-277417-f71jwdzj	260	41	high	high	JJ
cord-277417-f71jwdzj	260	42	virulence	virulence	NN
cord-277417-f71jwdzj	260	43	101	101	CD
cord-277417-f71jwdzj	260	44	(	(	-LRB-
cord-277417-f71jwdzj	260	45	and	and	CC
cord-277417-f71jwdzj	260	46	which	which	WDT
cord-277417-f71jwdzj	260	47	again	again	RB
cord-277417-f71jwdzj	260	48	may	may	MD
cord-277417-f71jwdzj	260	49	reflect	reflect	VB
cord-277417-f71jwdzj	260	50	the	the	DT
cord-277417-f71jwdzj	260	51	fairly	fairly	RB
cord-277417-f71jwdzj	260	52	large	large	JJ
cord-277417-f71jwdzj	260	53	size	size	NN
cord-277417-f71jwdzj	260	54	of	of	IN
cord-277417-f71jwdzj	260	55	the	the	DT
cord-277417-f71jwdzj	260	56	viral	viral	JJ
cord-277417-f71jwdzj	260	57	genome	genome	NN
cord-277417-f71jwdzj	260	58	)	)	-RRB-
cord-277417-f71jwdzj	260	59	.	.	.
cord-277417-f71jwdzj	261	1	Not	not	RB
cord-277417-f71jwdzj	261	2	only	only	RB
cord-277417-f71jwdzj	261	3	does	do	VBZ
cord-277417-f71jwdzj	261	4	virulence	virulence	NN
cord-277417-f71jwdzj	261	5	evolution	evolution	NN
cord-277417-f71jwdzj	261	6	in	in	IN
cord-277417-f71jwdzj	261	7	MDV	MDV	NNP
cord-277417-f71jwdzj	261	8	have	have	VBP
cord-277417-f71jwdzj	261	9	important	important	JJ
cord-277417-f71jwdzj	261	10	implications	implication	NNS
cord-277417-f71jwdzj	261	11	for	for	IN
cord-277417-f71jwdzj	261	12	vaccination	vaccination	NN
cord-277417-f71jwdzj	261	13	strategies	strategy	NNS
cord-277417-f71jwdzj	261	14	against	against	IN
cord-277417-f71jwdzj	261	15	other	other	JJ
cord-277417-f71jwdzj	261	16	diseases	disease	NNS
cord-277417-f71jwdzj	261	17	in	in	IN
cord-277417-f71jwdzj	261	18	which	which	WDT
cord-277417-f71jwdzj	261	19	vaccine	vaccine	NN
cord-277417-f71jwdzj	261	20	efficacy	efficacy	NN
cord-277417-f71jwdzj	261	21	is	be	VBZ
cord-277417-f71jwdzj	261	22	fairly	fairly	RB
cord-277417-f71jwdzj	261	23	low	low	JJ
cord-277417-f71jwdzj	261	24	102	102	CD
cord-277417-f71jwdzj	261	25	,	,	,
cord-277417-f71jwdzj	261	26	but	but	CC
cord-277417-f71jwdzj	261	27	it	-PRON-	PRP
cord-277417-f71jwdzj	261	28	also	also	RB
cord-277417-f71jwdzj	261	29	shows	show	VBZ
cord-277417-f71jwdzj	261	30	that	that	IN
cord-277417-f71jwdzj	261	31	in	in	IN
cord-277417-f71jwdzj	261	32	some	some	DT
cord-277417-f71jwdzj	261	33	circumstances	circumstance	NNS
cord-277417-f71jwdzj	261	34	increased	increase	VBD
cord-277417-f71jwdzj	261	35	virulence	virulence	NN
cord-277417-f71jwdzj	261	36	can	can	MD
cord-277417-f71jwdzj	261	37	be	be	VB
cord-277417-f71jwdzj	261	38	selectively	selectively	RB
cord-277417-f71jwdzj	261	39	advantageous	advantageous	JJ
cord-277417-f71jwdzj	261	40	.	.	.
cord-277417-f71jwdzj	262	1	Given	give	VBN
cord-277417-f71jwdzj	262	2	the	the	DT
cord-277417-f71jwdzj	262	3	importance	importance	NN
cord-277417-f71jwdzj	262	4	of	of	IN
cord-277417-f71jwdzj	262	5	HIV	HIV	NNP
cord-277417-f71jwdzj	262	6	to	to	IN
cord-277417-f71jwdzj	262	7	human	human	JJ
cord-277417-f71jwdzj	262	8	health	health	NN
cord-277417-f71jwdzj	262	9	and	and	CC
cord-277417-f71jwdzj	262	10	that	that	IN
cord-277417-f71jwdzj	262	11	it	-PRON-	PRP
cord-277417-f71jwdzj	262	12	ignited	ignite	VBD
cord-277417-f71jwdzj	262	13	much	much	JJ
cord-277417-f71jwdzj	262	14	of	of	IN
cord-277417-f71jwdzj	262	15	the	the	DT
cord-277417-f71jwdzj	262	16	research	research	NN
cord-277417-f71jwdzj	262	17	on	on	IN
cord-277417-f71jwdzj	262	18	disease	disease	NN
cord-277417-f71jwdzj	262	19	emergence	emergence	NN
cord-277417-f71jwdzj	262	20	,	,	,
cord-277417-f71jwdzj	262	21	it	-PRON-	PRP
cord-277417-f71jwdzj	262	22	is	be	VBZ
cord-277417-f71jwdzj	262	23	no	no	DT
cord-277417-f71jwdzj	262	24	surprise	surprise	NN
cord-277417-f71jwdzj	262	25	that	that	IN
cord-277417-f71jwdzj	262	26	there	there	EX
cord-277417-f71jwdzj	262	27	has	have	VBZ
cord-277417-f71jwdzj	262	28	been	be	VBN
cord-277417-f71jwdzj	262	29	considerable	considerable	JJ
cord-277417-f71jwdzj	262	30	discussion	discussion	NN
cord-277417-f71jwdzj	262	31	on	on	IN
cord-277417-f71jwdzj	262	32	the	the	DT
cord-277417-f71jwdzj	262	33	evolution	evolution	NN
cord-277417-f71jwdzj	262	34	of	of	IN
cord-277417-f71jwdzj	262	35	HIV	HIV	NNP
cord-277417-f71jwdzj	262	36	virulence	virulence	NN
cord-277417-f71jwdzj	262	37	[	[	-LRB-
cord-277417-f71jwdzj	262	38	103	103	CD
cord-277417-f71jwdzj	262	39	]	]	-RRB-
cord-277417-f71jwdzj	262	40	[	[	-LRB-
cord-277417-f71jwdzj	262	41	104	104	CD
cord-277417-f71jwdzj	262	42	]	]	-RRB-
cord-277417-f71jwdzj	262	43	[	[	-LRB-
cord-277417-f71jwdzj	262	44	105	105	CD
cord-277417-f71jwdzj	262	45	]	]	-RRB-
cord-277417-f71jwdzj	262	46	[	[	-LRB-
cord-277417-f71jwdzj	262	47	106	106	CD
cord-277417-f71jwdzj	262	48	]	]	-RRB-
cord-277417-f71jwdzj	262	49	[	[	-LRB-
cord-277417-f71jwdzj	262	50	107	107	CD
cord-277417-f71jwdzj	262	51	]	]	-RRB-
cord-277417-f71jwdzj	262	52	.	.	.
cord-277417-f71jwdzj	263	1	Indeed	indeed	RB
cord-277417-f71jwdzj	263	2	,	,	,
cord-277417-f71jwdzj	263	3	it	-PRON-	PRP
cord-277417-f71jwdzj	263	4	is	be	VBZ
cord-277417-f71jwdzj	263	5	striking	strike	VBG
cord-277417-f71jwdzj	263	6	that	that	IN
cord-277417-f71jwdzj	263	7	HIV	HIV	NNP
cord-277417-f71jwdzj	263	8	in	in	IN
cord-277417-f71jwdzj	263	9	humans	human	NNS
cord-277417-f71jwdzj	263	10	is	be	VBZ
cord-277417-f71jwdzj	263	11	markedly	markedly	RB
cord-277417-f71jwdzj	264	1	www.nature.com/nrg	www.nature.com/nrg	NNP
cord-277417-f71jwdzj	264	2	R	r	NN
cord-277417-f71jwdzj	264	3	e	e	NN
cord-277417-f71jwdzj	264	4	v	v	NN
cord-277417-f71jwdzj	265	1	i	i	PRP
cord-277417-f71jwdzj	266	1	e	e	NNP
cord-277417-f71jwdzj	266	2	w	w	NNP
cord-277417-f71jwdzj	266	3	s	s	NNP
cord-277417-f71jwdzj	267	1	764	764	CD
cord-277417-f71jwdzj	267	2	|	|	CD
cord-277417-f71jwdzj	267	3	DECEMBER	DECEMBER	NNP
cord-277417-f71jwdzj	267	4	2018	2018	CD
cord-277417-f71jwdzj	267	5	|	|	NNP
cord-277417-f71jwdzj	267	6	voluME	voluME	NNP
cord-277417-f71jwdzj	267	7	19	19	CD
cord-277417-f71jwdzj	268	1	Influenza	Influenza	NNP
cord-277417-f71jwdzj	268	2	A	a	DT
cord-277417-f71jwdzj	268	3	viruses	virus	NNS
cord-277417-f71jwdzj	268	4	are	be	VBP
cord-277417-f71jwdzj	268	5	categorized	categorize	VBN
cord-277417-f71jwdzj	268	6	into	into	IN
cord-277417-f71jwdzj	268	7	subtypes	subtype	NNS
cord-277417-f71jwdzj	268	8	on	on	IN
cord-277417-f71jwdzj	268	9	the	the	DT
cord-277417-f71jwdzj	268	10	basis	basis	NN
cord-277417-f71jwdzj	268	11	of	of	IN
cord-277417-f71jwdzj	268	12	the	the	DT
cord-277417-f71jwdzj	268	13	diversity	diversity	NN
cord-277417-f71jwdzj	268	14	in	in	IN
cord-277417-f71jwdzj	268	15	two	two	CD
cord-277417-f71jwdzj	268	16	proteins	protein	NNS
cord-277417-f71jwdzj	268	17	present	present	JJ
cord-277417-f71jwdzj	268	18	in	in	IN
cord-277417-f71jwdzj	268	19	the	the	DT
cord-277417-f71jwdzj	268	20	viral	viral	JJ
cord-277417-f71jwdzj	268	21	envelope	envelope	NN
cord-277417-f71jwdzj	268	22	:	:	:
cord-277417-f71jwdzj	268	23	haemagglutinin	haemagglutinin	NNP
cord-277417-f71jwdzj	268	24	(	(	-LRB-
cord-277417-f71jwdzj	268	25	H	H	NNP
cord-277417-f71jwdzj	268	26	or	or	CC
cord-277417-f71jwdzj	268	27	HA	HA	NNP
cord-277417-f71jwdzj	268	28	)	)	-RRB-
cord-277417-f71jwdzj	268	29	and	and	CC
cord-277417-f71jwdzj	268	30	neuraminidase	neuraminidase	NN
cord-277417-f71jwdzj	268	31	(	(	-LRB-
cord-277417-f71jwdzj	268	32	N	N	NNP
cord-277417-f71jwdzj	268	33	or	or	CC
cord-277417-f71jwdzj	268	34	NA	NA	NNP
cord-277417-f71jwdzj	268	35	)	)	-RRB-
cord-277417-f71jwdzj	268	36	.	.	.
cord-277417-f71jwdzj	269	1	more	more	RBR
cord-277417-f71jwdzj	269	2	virulent	virulent	JJ
cord-277417-f71jwdzj	269	3	than	than	IN
cord-277417-f71jwdzj	269	4	the	the	DT
cord-277417-f71jwdzj	269	5	closely	closely	RB
cord-277417-f71jwdzj	269	6	related	related	JJ
cord-277417-f71jwdzj	269	7	viruses	virus	NNS
cord-277417-f71jwdzj	269	8	that	that	WDT
cord-277417-f71jwdzj	269	9	naturally	naturally	RB
cord-277417-f71jwdzj	269	10	infect	infect	VBP
cord-277417-f71jwdzj	269	11	non	non	JJ
cord-277417-f71jwdzj	269	12	-	-	JJ
cord-277417-f71jwdzj	269	13	human	human	JJ
cord-277417-f71jwdzj	269	14	primates	primate	NNS
cord-277417-f71jwdzj	269	15	in	in	IN
cord-277417-f71jwdzj	269	16	Africa	Africa	NNP
cord-277417-f71jwdzj	269	17	(	(	-LRB-
cord-277417-f71jwdzj	269	18	box	box	NN
cord-277417-f71jwdzj	269	19	1	1	CD
cord-277417-f71jwdzj	269	20	)	)	-RRB-
cord-277417-f71jwdzj	269	21	.	.	.
cord-277417-f71jwdzj	270	1	Although	although	IN
cord-277417-f71jwdzj	270	2	there	there	EX
cord-277417-f71jwdzj	270	3	have	have	VBP
cord-277417-f71jwdzj	270	4	been	be	VBN
cord-277417-f71jwdzj	270	5	suggestions	suggestion	NNS
cord-277417-f71jwdzj	270	6	that	that	IN
cord-277417-f71jwdzj	270	7	HIV	HIV	NNP
cord-277417-f71jwdzj	270	8	has	have	VBZ
cord-277417-f71jwdzj	270	9	begun	begin	VBN
cord-277417-f71jwdzj	270	10	to	to	TO
cord-277417-f71jwdzj	270	11	evolve	evolve	VB
cord-277417-f71jwdzj	270	12	reduced	reduce	VBN
cord-277417-f71jwdzj	270	13	virulence	virulence	NN
cord-277417-f71jwdzj	270	14	108	108	CD
cord-277417-f71jwdzj	270	15	,	,	,
cord-277417-f71jwdzj	270	16	discussions	discussion	NNS
cord-277417-f71jwdzj	270	17	of	of	IN
cord-277417-f71jwdzj	270	18	the	the	DT
cord-277417-f71jwdzj	270	19	trajectory	trajectory	NN
cord-277417-f71jwdzj	270	20	of	of	IN
cord-277417-f71jwdzj	270	21	virulence	virulence	NN
cord-277417-f71jwdzj	270	22	evolution	evolution	NN
cord-277417-f71jwdzj	270	23	are	be	VBP
cord-277417-f71jwdzj	270	24	necessarily	necessarily	RB
cord-277417-f71jwdzj	270	25	complicated	complicate	VBN
cord-277417-f71jwdzj	270	26	by	by	IN
cord-277417-f71jwdzj	270	27	the	the	DT
cord-277417-f71jwdzj	270	28	fact	fact	NN
cord-277417-f71jwdzj	270	29	that	that	IN
cord-277417-f71jwdzj	270	30	antiviral	antiviral	JJ
cord-277417-f71jwdzj	270	31	therapy	therapy	NN
cord-277417-f71jwdzj	270	32	has	have	VBZ
cord-277417-f71jwdzj	270	33	greatly	greatly	RB
cord-277417-f71jwdzj	270	34	extended	extend	VBN
cord-277417-f71jwdzj	270	35	life	life	NN
cord-277417-f71jwdzj	270	36	expectancy	expectancy	NN
cord-277417-f71jwdzj	270	37	.	.	.
cord-277417-f71jwdzj	271	1	HIV	HIV	NNP
cord-277417-f71jwdzj	271	2	virulence	virulence	NN
cord-277417-f71jwdzj	271	3	is	be	VBZ
cord-277417-f71jwdzj	271	4	often	often	RB
cord-277417-f71jwdzj	271	5	approximated	approximate	VBN
cord-277417-f71jwdzj	271	6	as	as	IN
cord-277417-f71jwdzj	271	7	the	the	DT
cord-277417-f71jwdzj	271	8	degree	degree	NN
cord-277417-f71jwdzj	271	9	of	of	IN
cord-277417-f71jwdzj	271	10	variation	variation	NN
cord-277417-f71jwdzj	271	11	in	in	IN
cord-277417-f71jwdzj	271	12	the	the	DT
cord-277417-f71jwdzj	271	13	set	set	NN
cord-277417-f71jwdzj	271	14	point	point	NN
cord-277417-f71jwdzj	271	15	viral	viral	JJ
cord-277417-f71jwdzj	271	16	load	load	NN
cord-277417-f71jwdzj	271	17	(	(	-LRB-
cord-277417-f71jwdzj	271	18	SPVL	SPVL	NNP
cord-277417-f71jwdzj	271	19	)	)	-RRB-
cord-277417-f71jwdzj	271	20	that	that	WDT
cord-277417-f71jwdzj	271	21	is	be	VBZ
cord-277417-f71jwdzj	271	22	established	establish	VBN
cord-277417-f71jwdzj	271	23	soon	soon	RB
cord-277417-f71jwdzj	271	24	after	after	IN
cord-277417-f71jwdzj	271	25	initial	initial	JJ
cord-277417-f71jwdzj	271	26	infection	infection	NN
cord-277417-f71jwdzj	271	27	104	104	CD
cord-277417-f71jwdzj	271	28	.	.	.
cord-277417-f71jwdzj	272	1	The	the	DT
cord-277417-f71jwdzj	272	2	higher	high	JJR
cord-277417-f71jwdzj	272	3	the	the	DT
cord-277417-f71jwdzj	272	4	SPVL	SPVL	NNP
cord-277417-f71jwdzj	272	5	,	,	,
cord-277417-f71jwdzj	272	6	reflecting	reflect	VBG
cord-277417-f71jwdzj	272	7	greater	great	JJR
cord-277417-f71jwdzj	272	8	levels	level	NNS
cord-277417-f71jwdzj	272	9	of	of	IN
cord-277417-f71jwdzj	272	10	virus	virus	NN
cord-277417-f71jwdzj	272	11	replication	replication	NN
cord-277417-f71jwdzj	272	12	,	,	,
cord-277417-f71jwdzj	272	13	then	then	RB
cord-277417-f71jwdzj	272	14	the	the	DT
cord-277417-f71jwdzj	272	15	more	more	RBR
cord-277417-f71jwdzj	272	16	rapidly	rapidly	RB
cord-277417-f71jwdzj	272	17	the	the	DT
cord-277417-f71jwdzj	272	18	patient	patient	NN
cord-277417-f71jwdzj	272	19	will	will	MD
cord-277417-f71jwdzj	272	20	progress	progress	VB
cord-277417-f71jwdzj	272	21	to	to	IN
cord-277417-f71jwdzj	272	22	AIDS	AIDS	NNP
cord-277417-f71jwdzj	272	23	in	in	IN
cord-277417-f71jwdzj	272	24	the	the	DT
cord-277417-f71jwdzj	272	25	absence	absence	NN
cord-277417-f71jwdzj	272	26	of	of	IN
cord-277417-f71jwdzj	272	27	antiviral	antiviral	JJ
cord-277417-f71jwdzj	272	28	therapy	therapy	NN
cord-277417-f71jwdzj	272	29	,	,	,
cord-277417-f71jwdzj	272	30	although	although	IN
cord-277417-f71jwdzj	272	31	other	other	JJ
cord-277417-f71jwdzj	272	32	studies	study	NNS
cord-277417-f71jwdzj	272	33	have	have	VBP
cord-277417-f71jwdzj	272	34	suggested	suggest	VBN
cord-277417-f71jwdzj	272	35	that	that	IN
cord-277417-f71jwdzj	272	36	the	the	DT
cord-277417-f71jwdzj	272	37	replicative	replicative	JJ
cord-277417-f71jwdzj	272	38	capacity	capacity	NN
cord-277417-f71jwdzj	272	39	of	of	IN
cord-277417-f71jwdzj	272	40	the	the	DT
cord-277417-f71jwdzj	272	41	virus	virus	NN
cord-277417-f71jwdzj	272	42	itself	-PRON-	PRP
cord-277417-f71jwdzj	272	43	is	be	VBZ
cord-277417-f71jwdzj	272	44	a	a	DT
cord-277417-f71jwdzj	272	45	more	more	RBR
cord-277417-f71jwdzj	272	46	informative	informative	JJ
cord-277417-f71jwdzj	272	47	marker	marker	NN
cord-277417-f71jwdzj	272	48	of	of	IN
cord-277417-f71jwdzj	272	49	virulence	virulence	NN
cord-277417-f71jwdzj	272	50	and	and	CC
cord-277417-f71jwdzj	272	51	is	be	VBZ
cord-277417-f71jwdzj	272	52	also	also	RB
cord-277417-f71jwdzj	272	53	a	a	DT
cord-277417-f71jwdzj	272	54	direct	direct	JJ
cord-277417-f71jwdzj	272	55	measure	measure	NN
cord-277417-f71jwdzj	272	56	of	of	IN
cord-277417-f71jwdzj	272	57	virus	virus	NN
cord-277417-f71jwdzj	272	58	fitness	fitness	NN
cord-277417-f71jwdzj	272	59	109	109	CD
cord-277417-f71jwdzj	272	60	.	.	.
cord-277417-f71jwdzj	273	1	Indeed	indeed	RB
cord-277417-f71jwdzj	273	2	,	,	,
cord-277417-f71jwdzj	273	3	some	some	DT
cord-277417-f71jwdzj	273	4	'	'	``
cord-277417-f71jwdzj	273	5	controller	controller	NN
cord-277417-f71jwdzj	273	6	'	'	''
cord-277417-f71jwdzj	273	7	individuals	individual	NNS
cord-277417-f71jwdzj	273	8	are	be	VBP
cord-277417-f71jwdzj	273	9	able	able	JJ
cord-277417-f71jwdzj	273	10	to	to	TO
cord-277417-f71jwdzj	273	11	control	control	VB
cord-277417-f71jwdzj	273	12	levels	level	NNS
cord-277417-f71jwdzj	273	13	of	of	IN
cord-277417-f71jwdzj	273	14	HIV	HIV	NNP
cord-277417-f71jwdzj	273	15	in	in	IN
cord-277417-f71jwdzj	273	16	the	the	DT
cord-277417-f71jwdzj	273	17	absence	absence	NN
cord-277417-f71jwdzj	273	18	of	of	IN
cord-277417-f71jwdzj	273	19	antiviral	antiviral	JJ
cord-277417-f71jwdzj	273	20	therapy	therapy	NN
cord-277417-f71jwdzj	273	21	,	,	,
cord-277417-f71jwdzj	273	22	and	and	CC
cord-277417-f71jwdzj	273	23	it	-PRON-	PRP
cord-277417-f71jwdzj	273	24	has	have	VBZ
cord-277417-f71jwdzj	273	25	been	be	VBN
cord-277417-f71jwdzj	273	26	shown	show	VBN
cord-277417-f71jwdzj	273	27	that	that	IN
cord-277417-f71jwdzj	273	28	this	this	DT
cord-277417-f71jwdzj	273	29	is	be	VBZ
cord-277417-f71jwdzj	273	30	in	in	IN
cord-277417-f71jwdzj	273	31	part	part	NN
cord-277417-f71jwdzj	273	32	due	due	IN
cord-277417-f71jwdzj	273	33	to	to	IN
cord-277417-f71jwdzj	273	34	infection	infection	NN
cord-277417-f71jwdzj	273	35	with	with	IN
cord-277417-f71jwdzj	273	36	viruses	virus	NNS
cord-277417-f71jwdzj	273	37	of	of	IN
cord-277417-f71jwdzj	273	38	reduced	reduce	VBN
cord-277417-f71jwdzj	273	39	replicative	replicative	JJ
cord-277417-f71jwdzj	273	40	capacity	capacity	NN
cord-277417-f71jwdzj	273	41	110	110	CD
cord-277417-f71jwdzj	273	42	.	.	.
cord-277417-f71jwdzj	274	1	Importantly	importantly	RB
cord-277417-f71jwdzj	274	2	,	,	,
cord-277417-f71jwdzj	274	3	viral	viral	JJ
cord-277417-f71jwdzj	274	4	genetic	genetic	JJ
cord-277417-f71jwdzj	274	5	variation	variation	NN
cord-277417-f71jwdzj	274	6	may	may	MD
cord-277417-f71jwdzj	274	7	play	play	VB
cord-277417-f71jwdzj	274	8	a	a	DT
cord-277417-f71jwdzj	274	9	more	more	RBR
cord-277417-f71jwdzj	274	10	important	important	JJ
cord-277417-f71jwdzj	274	11	role	role	NN
cord-277417-f71jwdzj	274	12	in	in	IN
cord-277417-f71jwdzj	274	13	shaping	shape	VBG
cord-277417-f71jwdzj	274	14	HIV	HIV	NNP
cord-277417-f71jwdzj	274	15	virulence	virulence	NN
cord-277417-f71jwdzj	274	16	than	than	IN
cord-277417-f71jwdzj	274	17	host	host	NN
cord-277417-f71jwdzj	274	18	factors	factor	NNS
cord-277417-f71jwdzj	274	19	,	,	,
cord-277417-f71jwdzj	274	20	with	with	IN
cord-277417-f71jwdzj	274	21	approximately	approximately	RB
cord-277417-f71jwdzj	274	22	one	one	CD
cord-277417-f71jwdzj	274	23	-	-	HYPH
cord-277417-f71jwdzj	274	24	third	third	NN
cord-277417-f71jwdzj	274	25	of	of	IN
cord-277417-f71jwdzj	274	26	the	the	DT
cord-277417-f71jwdzj	274	27	observed	observed	JJ
cord-277417-f71jwdzj	274	28	variability	variability	NN
cord-277417-f71jwdzj	274	29	in	in	IN
cord-277417-f71jwdzj	274	30	SPVL	SPVL	NNP
cord-277417-f71jwdzj	274	31	assigned	assign	VBN
cord-277417-f71jwdzj	274	32	to	to	IN
cord-277417-f71jwdzj	274	33	virus	virus	NN
cord-277417-f71jwdzj	274	34	factors	factor	NNS
cord-277417-f71jwdzj	274	35	111	111	CD
cord-277417-f71jwdzj	274	36	and	and	CC
cord-277417-f71jwdzj	274	37	only	only	RB
cord-277417-f71jwdzj	274	38	~13	~13	NFP
cord-277417-f71jwdzj	274	39	%	%	NN
cord-277417-f71jwdzj	274	40	seemingly	seemingly	RB
cord-277417-f71jwdzj	274	41	due	due	JJ
cord-277417-f71jwdzj	274	42	to	to	IN
cord-277417-f71jwdzj	274	43	the	the	DT
cord-277417-f71jwdzj	274	44	host	host	NN
cord-277417-f71jwdzj	274	45	112	112	CD
cord-277417-f71jwdzj	274	46	.	.	.
cord-277417-f71jwdzj	275	1	This	this	DT
cord-277417-f71jwdzj	275	2	observation	observation	NN
cord-277417-f71jwdzj	275	3	also	also	RB
cord-277417-f71jwdzj	275	4	implies	imply	VBZ
cord-277417-f71jwdzj	275	5	that	that	IN
cord-277417-f71jwdzj	275	6	SPVL	SPVL	NNP
cord-277417-f71jwdzj	275	7	,	,	,
cord-277417-f71jwdzj	275	8	and	and	CC
cord-277417-f71jwdzj	275	9	hence	hence	RB
cord-277417-f71jwdzj	275	10	virulence	virulence	NN
cord-277417-f71jwdzj	275	11	,	,	,
cord-277417-f71jwdzj	275	12	can	can	MD
cord-277417-f71jwdzj	275	13	be	be	VB
cord-277417-f71jwdzj	275	14	selectively	selectively	RB
cord-277417-f71jwdzj	275	15	optimized	optimize	VBN
cord-277417-f71jwdzj	275	16	113	113	CD
cord-277417-f71jwdzj	275	17	.	.	.
cord-277417-f71jwdzj	276	1	In	in	IN
cord-277417-f71jwdzj	276	2	support	support	NN
cord-277417-f71jwdzj	276	3	is	be	VBZ
cord-277417-f71jwdzj	276	4	evidence	evidence	NN
cord-277417-f71jwdzj	276	5	that	that	IN
cord-277417-f71jwdzj	276	6	SPVL	SPVL	NNP
cord-277417-f71jwdzj	276	7	,	,	,
cord-277417-f71jwdzj	276	8	and	and	CC
cord-277417-f71jwdzj	276	9	hence	hence	RB
cord-277417-f71jwdzj	276	10	virulence	virulence	NN
cord-277417-f71jwdzj	276	11	,	,	,
cord-277417-f71jwdzj	276	12	has	have	VBZ
cord-277417-f71jwdzj	276	13	declined	decline	VBN
cord-277417-f71jwdzj	276	14	in	in	IN
cord-277417-f71jwdzj	276	15	some	some	DT
cord-277417-f71jwdzj	276	16	African	african	JJ
cord-277417-f71jwdzj	276	17	HIV	HIV	NNP
cord-277417-f71jwdzj	276	18	subtypes	subtype	NNS
cord-277417-f71jwdzj	276	19	,	,	,
cord-277417-f71jwdzj	276	20	even	even	RB
cord-277417-f71jwdzj	276	21	accounting	account	VBG
cord-277417-f71jwdzj	276	22	for	for	IN
cord-277417-f71jwdzj	276	23	the	the	DT
cord-277417-f71jwdzj	276	24	use	use	NN
cord-277417-f71jwdzj	276	25	of	of	IN
cord-277417-f71jwdzj	276	26	antiviral	antiviral	JJ
cord-277417-f71jwdzj	276	27	therapy	therapy	NN
cord-277417-f71jwdzj	276	28	,	,	,
cord-277417-f71jwdzj	276	29	and	and	CC
cord-277417-f71jwdzj	276	30	that	that	IN
cord-277417-f71jwdzj	276	31	this	this	DT
cord-277417-f71jwdzj	276	32	reflects	reflect	VBZ
cord-277417-f71jwdzj	276	33	a	a	DT
cord-277417-f71jwdzj	276	34	trade	trade	NN
cord-277417-f71jwdzj	276	35	-	-	HYPH
cord-277417-f71jwdzj	276	36	off	off	NN
cord-277417-f71jwdzj	276	37	between	between	IN
cord-277417-f71jwdzj	276	38	virulence	virulence	NN
cord-277417-f71jwdzj	276	39	and	and	CC
cord-277417-f71jwdzj	276	40	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	276	41	114	114	CD
cord-277417-f71jwdzj	276	42	.	.	.
cord-277417-f71jwdzj	277	1	Importantly	importantly	RB
cord-277417-f71jwdzj	277	2	,	,	,
cord-277417-f71jwdzj	277	3	however	however	RB
cord-277417-f71jwdzj	277	4	,	,	,
cord-277417-f71jwdzj	277	5	despite	despite	IN
cord-277417-f71jwdzj	277	6	many	many	JJ
cord-277417-f71jwdzj	277	7	studies	study	NNS
cord-277417-f71jwdzj	277	8	into	into	IN
cord-277417-f71jwdzj	277	9	the	the	DT
cord-277417-f71jwdzj	277	10	determinants	determinant	NNS
cord-277417-f71jwdzj	277	11	of	of	IN
cord-277417-f71jwdzj	277	12	HIV	HIV	NNP
cord-277417-f71jwdzj	277	13	virulence	virulence	NN
cord-277417-f71jwdzj	277	14	,	,	,
cord-277417-f71jwdzj	277	15	the	the	DT
cord-277417-f71jwdzj	277	16	virus	virus	NN
cord-277417-f71jwdzj	277	17	genomic	genomic	JJ
cord-277417-f71jwdzj	277	18	mutations	mutation	NNS
cord-277417-f71jwdzj	277	19	responsible	responsible	JJ
cord-277417-f71jwdzj	277	20	for	for	IN
cord-277417-f71jwdzj	277	21	determining	determine	VBG
cord-277417-f71jwdzj	277	22	SPVL	SPVL	NNP
cord-277417-f71jwdzj	277	23	are	be	VBP
cord-277417-f71jwdzj	277	24	still	still	RB
cord-277417-f71jwdzj	277	25	uncertain	uncertain	JJ
cord-277417-f71jwdzj	277	26	and	and	CC
cord-277417-f71jwdzj	277	27	multiple	multiple	JJ
cord-277417-f71jwdzj	277	28	genes	gene	NNS
cord-277417-f71jwdzj	277	29	may	may	MD
cord-277417-f71jwdzj	277	30	be	be	VB
cord-277417-f71jwdzj	277	31	involved	involve	VBN
cord-277417-f71jwdzj	277	32	104	104	CD
cord-277417-f71jwdzj	277	33	.	.	.
cord-277417-f71jwdzj	278	1	The	the	DT
cord-277417-f71jwdzj	278	2	difficulty	difficulty	NN
cord-277417-f71jwdzj	278	3	in	in	IN
cord-277417-f71jwdzj	278	4	assigning	assign	VBG
cord-277417-f71jwdzj	278	5	the	the	DT
cord-277417-f71jwdzj	278	6	genetic	genetic	JJ
cord-277417-f71jwdzj	278	7	determinants	determinant	NNS
cord-277417-f71jwdzj	278	8	of	of	IN
cord-277417-f71jwdzj	278	9	SPVL	SPVL	NNP
cord-277417-f71jwdzj	278	10	may	may	MD
cord-277417-f71jwdzj	278	11	be	be	VB
cord-277417-f71jwdzj	278	12	in	in	IN
cord-277417-f71jwdzj	278	13	part	part	NN
cord-277417-f71jwdzj	278	14	due	due	IN
cord-277417-f71jwdzj	278	15	to	to	IN
cord-277417-f71jwdzj	278	16	genetic	genetic	JJ
cord-277417-f71jwdzj	278	17	variation	variation	NN
cord-277417-f71jwdzj	278	18	across	across	IN
cord-277417-f71jwdzj	278	19	viral	viral	JJ
cord-277417-f71jwdzj	278	20	populations	population	NNS
cord-277417-f71jwdzj	278	21	111	111	CD
cord-277417-f71jwdzj	278	22	.	.	.
cord-277417-f71jwdzj	279	1	For	for	IN
cord-277417-f71jwdzj	279	2	example	example	NN
cord-277417-f71jwdzj	279	3	,	,	,
cord-277417-f71jwdzj	279	4	heritability	heritability	NN
cord-277417-f71jwdzj	279	5	in	in	IN
cord-277417-f71jwdzj	279	6	SPVL	SPVL	NNP
cord-277417-f71jwdzj	279	7	was	be	VBD
cord-277417-f71jwdzj	279	8	highest	high	JJS
cord-277417-f71jwdzj	279	9	(	(	-LRB-
cord-277417-f71jwdzj	279	10	~60	~60	CD
cord-277417-f71jwdzj	279	11	%	%	NN
cord-277417-f71jwdzj	279	12	)	)	-RRB-
cord-277417-f71jwdzj	279	13	between	between	IN
cord-277417-f71jwdzj	279	14	individuals	individual	NNS
cord-277417-f71jwdzj	279	15	in	in	IN
cord-277417-f71jwdzj	279	16	the	the	DT
cord-277417-f71jwdzj	279	17	Swiss	swiss	JJ
cord-277417-f71jwdzj	279	18	HIV	HIV	NNP
cord-277417-f71jwdzj	279	19	cohort	cohort	NN
cord-277417-f71jwdzj	279	20	,	,	,
cord-277417-f71jwdzj	279	21	which	which	WDT
cord-277417-f71jwdzj	279	22	also	also	RB
cord-277417-f71jwdzj	279	23	represents	represent	VBZ
cord-277417-f71jwdzj	279	24	the	the	DT
cord-277417-f71jwdzj	279	25	most	most	RBS
cord-277417-f71jwdzj	279	26	homogenous	homogenous	JJ
cord-277417-f71jwdzj	279	27	viral	viral	JJ
cord-277417-f71jwdzj	279	28	population	population	NN
cord-277417-f71jwdzj	279	29	113	113	CD
cord-277417-f71jwdzj	279	30	Marek	Marek	NNP
cord-277417-f71jwdzj	279	31	's	's	POS
cord-277417-f71jwdzj	279	32	disease	disease	NN
cord-277417-f71jwdzj	279	33	virus	virus	NN
cord-277417-f71jwdzj	279	34	(	(	-LRB-
cord-277417-f71jwdzj	279	35	MDV	MDV	NNP
cord-277417-f71jwdzj	279	36	)	)	-RRB-
cord-277417-f71jwdzj	279	37	of	of	IN
cord-277417-f71jwdzj	279	38	chickens	chicken	NNS
cord-277417-f71jwdzj	279	39	present	present	JJ
cord-277417-f71jwdzj	279	40	on	on	IN
cord-277417-f71jwdzj	279	41	poultry	poultry	NN
cord-277417-f71jwdzj	279	42	farms	farm	NNS
cord-277417-f71jwdzj	279	43	.	.	.
cord-277417-f71jwdzj	280	1	This	this	DT
cord-277417-f71jwdzj	280	2	imperfect	imperfect	JJ
cord-277417-f71jwdzj	280	3	vaccine	vaccine	NN
cord-277417-f71jwdzj	280	4	reduced	reduce	VBN
cord-277417-f71jwdzj	280	5	disease	disease	NN
cord-277417-f71jwdzj	280	6	symptoms	symptom	NNS
cord-277417-f71jwdzj	280	7	but	but	CC
cord-277417-f71jwdzj	280	8	did	do	VBD
cord-277417-f71jwdzj	280	9	not	not	RB
cord-277417-f71jwdzj	280	10	prevent	prevent	VB
cord-277417-f71jwdzj	280	11	virus	virus	NN
cord-277417-f71jwdzj	280	12	replication	replication	NN
cord-277417-f71jwdzj	280	13	,	,	,
cord-277417-f71jwdzj	280	14	thereby	thereby	RB
cord-277417-f71jwdzj	280	15	extending	extend	VBG
cord-277417-f71jwdzj	280	16	the	the	DT
cord-277417-f71jwdzj	280	17	infectious	infectious	JJ
cord-277417-f71jwdzj	280	18	periods	period	NNS
cord-277417-f71jwdzj	280	19	,	,	,
cord-277417-f71jwdzj	280	20	and	and	CC
cord-277417-f71jwdzj	280	21	hence	hence	RB
cord-277417-f71jwdzj	280	22	potential	potential	JJ
cord-277417-f71jwdzj	280	23	for	for	IN
cord-277417-f71jwdzj	280	24	transmission	transmission	NN
cord-277417-f71jwdzj	280	25	,	,	,
cord-277417-f71jwdzj	280	26	of	of	IN
cord-277417-f71jwdzj	280	27	virulent	virulent	JJ
cord-277417-f71jwdzj	280	28	strains	strain	NNS
cord-277417-f71jwdzj	280	29	that	that	WDT
cord-277417-f71jwdzj	280	30	would	would	MD
cord-277417-f71jwdzj	280	31	have	have	VB
cord-277417-f71jwdzj	280	32	been	be	VBN
cord-277417-f71jwdzj	280	33	removed	remove	VBN
cord-277417-f71jwdzj	280	34	by	by	IN
cord-277417-f71jwdzj	280	35	natural	natural	JJ
cord-277417-f71jwdzj	280	36	selection	selection	NN
cord-277417-f71jwdzj	280	37	before	before	IN
cord-277417-f71jwdzj	280	38	transmission	transmission	NN
cord-277417-f71jwdzj	280	39	to	to	IN
cord-277417-f71jwdzj	280	40	a	a	DT
cord-277417-f71jwdzj	280	41	new	new	JJ
cord-277417-f71jwdzj	280	42	host	host	NN
cord-277417-f71jwdzj	280	43	in	in	IN
cord-277417-f71jwdzj	280	44	the	the	DT
cord-277417-f71jwdzj	280	45	pre	pre	JJ
cord-277417-f71jwdzj	280	46	-	-	JJ
cord-277417-f71jwdzj	280	47	vaccine	vaccine	JJ
cord-277417-f71jwdzj	280	48	era	era	NN
cord-277417-f71jwdzj	280	49	99	99	CD
cord-277417-f71jwdzj	280	50	.	.	.
cord-277417-f71jwdzj	281	1	Because	because	IN
cord-277417-f71jwdzj	281	2	of	of	IN
cord-277417-f71jwdzj	281	3	this	this	DT
cord-277417-f71jwdzj	281	4	,	,	,
cord-277417-f71jwdzj	281	5	'	'	''
cord-277417-f71jwdzj	281	6	very	very	RB
cord-277417-f71jwdzj	281	7	virulent	virulent	JJ
cord-277417-f71jwdzj	281	8	'	'	''
cord-277417-f71jwdzj	281	9	MDV	mdv	NN
cord-277417-f71jwdzj	281	10	began	begin	VBD
cord-277417-f71jwdzj	281	11	to	to	TO
cord-277417-f71jwdzj	281	12	appear	appear	VB
cord-277417-f71jwdzj	281	13	within	within	IN
cord-277417-f71jwdzj	281	14	10	10	CD
cord-277417-f71jwdzj	281	15	years	year	NNS
cord-277417-f71jwdzj	281	16	,	,	,
cord-277417-f71jwdzj	281	17	necessitating	necessitate	VBG
cord-277417-f71jwdzj	281	18	the	the	DT
cord-277417-f71jwdzj	281	19	development	development	NN
cord-277417-f71jwdzj	281	20	of	of	IN
cord-277417-f71jwdzj	281	21	a	a	DT
cord-277417-f71jwdzj	281	22	secondgeneration	secondgeneration	NN
cord-277417-f71jwdzj	281	23	vaccine	vaccine	NN
cord-277417-f71jwdzj	281	24	that	that	WDT
cord-277417-f71jwdzj	281	25	was	be	VBD
cord-277417-f71jwdzj	281	26	also	also	RB
cord-277417-f71jwdzj	281	27	imperfect	imperfect	JJ
cord-277417-f71jwdzj	281	28	.	.	.
cord-277417-f71jwdzj	282	1	This	this	DT
cord-277417-f71jwdzj	282	2	was	be	VBD
cord-277417-f71jwdzj	282	3	followed	follow	VBN
cord-277417-f71jwdzj	282	4	,	,	,
cord-277417-f71jwdzj	282	5	in	in	IN
cord-277417-f71jwdzj	282	6	an	an	DT
cord-277417-f71jwdzj	282	7	even	even	RB
cord-277417-f71jwdzj	282	8	shorter	short	JJR
cord-277417-f71jwdzj	282	9	period	period	NN
cord-277417-f71jwdzj	282	10	,	,	,
cord-277417-f71jwdzj	282	11	by	by	IN
cord-277417-f71jwdzj	282	12	the	the	DT
cord-277417-f71jwdzj	282	13	appearance	appearance	NN
cord-277417-f71jwdzj	282	14	of	of	IN
cord-277417-f71jwdzj	282	15	'	'	``
cord-277417-f71jwdzj	282	16	very	very	RB
cord-277417-f71jwdzj	282	17	virulent	virulent	JJ
cord-277417-f71jwdzj	282	18	plus	plus	CC
cord-277417-f71jwdzj	282	19	'	'	''
cord-277417-f71jwdzj	282	20	MDV	mdv	NN
cord-277417-f71jwdzj	282	21	,	,	,
cord-277417-f71jwdzj	282	22	requiring	require	VBG
cord-277417-f71jwdzj	282	23	a	a	DT
cord-277417-f71jwdzj	282	24	third	third	JJ
cord-277417-f71jwdzj	282	25	-	-	HYPH
cord-277417-f71jwdzj	282	26	generation	generation	NN
cord-277417-f71jwdzj	282	27	vaccine	vaccine	NN
cord-277417-f71jwdzj	282	28	.	.	.
cord-277417-f71jwdzj	283	1	Although	although	IN
cord-277417-f71jwdzj	283	2	the	the	DT
cord-277417-f71jwdzj	283	3	genomic	genomic	JJ
cord-277417-f71jwdzj	283	4	basis	basis	NN
cord-277417-f71jwdzj	283	5	of	of	IN
cord-277417-f71jwdzj	283	6	MDV	MDV	NNP
cord-277417-f71jwdzj	283	7	virulence	virulence	NN
cord-277417-f71jwdzj	283	8	is	be	VBZ
cord-277417-f71jwdzj	283	9	currently	currently	RB
cord-277417-f71jwdzj	283	10	unknown	unknown	JJ
cord-277417-f71jwdzj	283	11	,	,	,
cord-277417-f71jwdzj	283	12	the	the	DT
cord-277417-f71jwdzj	283	13	phylogenies	phylogeny	NNS
cord-277417-f71jwdzj	283	14	at	at	IN
cord-277417-f71jwdzj	283	15	the	the	DT
cord-277417-f71jwdzj	283	16	bottom	bottom	NN
cord-277417-f71jwdzj	283	17	of	of	IN
cord-277417-f71jwdzj	283	18	the	the	DT
cord-277417-f71jwdzj	283	19	figure	figure	NN
cord-277417-f71jwdzj	283	20	hypothetically	hypothetically	RB
cord-277417-f71jwdzj	283	21	assign	assign	VB
cord-277417-f71jwdzj	283	22	virulence	virulence	NN
cord-277417-f71jwdzj	283	23	to	to	IN
cord-277417-f71jwdzj	283	24	multiple	multiple	JJ
cord-277417-f71jwdzj	283	25	causative	causative	JJ
cord-277417-f71jwdzj	283	26	mutations	mutation	NNS
cord-277417-f71jwdzj	283	27	(	(	-LRB-
cord-277417-f71jwdzj	283	28	as	as	IN
cord-277417-f71jwdzj	283	29	in	in	IN
cord-277417-f71jwdzj	283	30	the	the	DT
cord-277417-f71jwdzj	283	31	case	case	NN
cord-277417-f71jwdzj	283	32	of	of	IN
cord-277417-f71jwdzj	283	33	myxoma	myxoma	NNP
cord-277417-f71jwdzj	283	34	virus	virus	NN
cord-277417-f71jwdzj	283	35	)	)	-RRB-
cord-277417-f71jwdzj	283	36	.	.	.
cord-277417-f71jwdzj	284	1	The	the	DT
cord-277417-f71jwdzj	284	2	dashed	dash	VBN
cord-277417-f71jwdzj	284	3	arrows	arrow	NNS
cord-277417-f71jwdzj	284	4	indicate	indicate	VBP
cord-277417-f71jwdzj	284	5	the	the	DT
cord-277417-f71jwdzj	284	6	evolution	evolution	NN
cord-277417-f71jwdzj	284	7	of	of	IN
cord-277417-f71jwdzj	284	8	viruses	virus	NNS
cord-277417-f71jwdzj	284	9	to	to	IN
cord-277417-f71jwdzj	284	10	the	the	DT
cord-277417-f71jwdzj	284	11	next	next	JJ
cord-277417-f71jwdzj	284	12	virulence	virulence	NN
cord-277417-f71jwdzj	284	13	grade	grade	NN
cord-277417-f71jwdzj	284	14	.	.	.
cord-277417-f71jwdzj	285	1	The	the	DT
cord-277417-f71jwdzj	285	2	amount	amount	NN
cord-277417-f71jwdzj	285	3	of	of	IN
cord-277417-f71jwdzj	285	4	phenotypic	phenotypic	JJ
cord-277417-f71jwdzj	285	5	variation	variation	NN
cord-277417-f71jwdzj	285	6	in	in	IN
cord-277417-f71jwdzj	285	7	a	a	DT
cord-277417-f71jwdzj	285	8	population	population	NN
cord-277417-f71jwdzj	285	9	that	that	WDT
cord-277417-f71jwdzj	285	10	is	be	VBZ
cord-277417-f71jwdzj	285	11	attributable	attributable	JJ
cord-277417-f71jwdzj	285	12	to	to	IN
cord-277417-f71jwdzj	285	13	individual	individual	JJ
cord-277417-f71jwdzj	285	14	genetic	genetic	JJ
cord-277417-f71jwdzj	285	15	differences	difference	NNS
cord-277417-f71jwdzj	285	16	.	.	.
cord-277417-f71jwdzj	286	1	The	the	DT
cord-277417-f71jwdzj	286	2	2013	2013	CD
cord-277417-f71jwdzj	286	3	-	-	SYM
cord-277417-f71jwdzj	286	4	2016	2016	CD
cord-277417-f71jwdzj	286	5	outbreak	outbreak	NN
cord-277417-f71jwdzj	286	6	of	of	IN
cord-277417-f71jwdzj	286	7	EBOV	EBOV	NNP
cord-277417-f71jwdzj	286	8	(	(	-LRB-
cord-277417-f71jwdzj	286	9	Makona	Makona	NNP
cord-277417-f71jwdzj	286	10	variant	variant	NN
cord-277417-f71jwdzj	286	11	)	)	-RRB-
cord-277417-f71jwdzj	286	12	in	in	IN
cord-277417-f71jwdzj	286	13	West	West	NNP
cord-277417-f71jwdzj	286	14	Africa	Africa	NNP
cord-277417-f71jwdzj	286	15	was	be	VBD
cord-277417-f71jwdzj	286	16	the	the	DT
cord-277417-f71jwdzj	286	17	largest	large	JJS
cord-277417-f71jwdzj	286	18	and	and	CC
cord-277417-f71jwdzj	286	19	longest	long	RBS
cord-277417-f71jwdzj	286	20	described	describe	VBN
cord-277417-f71jwdzj	286	21	in	in	IN
cord-277417-f71jwdzj	286	22	humans	human	NNS
cord-277417-f71jwdzj	286	23	since	since	IN
cord-277417-f71jwdzj	286	24	the	the	DT
cord-277417-f71jwdzj	286	25	first	first	JJ
cord-277417-f71jwdzj	286	26	description	description	NN
cord-277417-f71jwdzj	286	27	of	of	IN
cord-277417-f71jwdzj	286	28	the	the	DT
cord-277417-f71jwdzj	286	29	disease	disease	NN
cord-277417-f71jwdzj	286	30	in	in	IN
cord-277417-f71jwdzj	286	31	1976	1976	CD
cord-277417-f71jwdzj	286	32	,	,	,
cord-277417-f71jwdzj	286	33	with	with	IN
cord-277417-f71jwdzj	286	34	approximately	approximately	RB
cord-277417-f71jwdzj	286	35	29,000	29,000	CD
cord-277417-f71jwdzj	286	36	cases	case	NNS
cord-277417-f71jwdzj	286	37	and	and	CC
cord-277417-f71jwdzj	286	38	some	some	DT
cord-277417-f71jwdzj	286	39	11,000	11,000	CD
cord-277417-f71jwdzj	286	40	deaths	death	NNS
cord-277417-f71jwdzj	286	41	.	.	.
cord-277417-f71jwdzj	287	1	In	in	IN
cord-277417-f71jwdzj	287	2	addition	addition	NN
cord-277417-f71jwdzj	287	3	to	to	IN
cord-277417-f71jwdzj	287	4	hindering	hinder	VBG
cord-277417-f71jwdzj	287	5	attempts	attempt	NNS
cord-277417-f71jwdzj	287	6	at	at	IN
cord-277417-f71jwdzj	287	7	disease	disease	NN
cord-277417-f71jwdzj	287	8	control	control	NN
cord-277417-f71jwdzj	287	9	,	,	,
cord-277417-f71jwdzj	287	10	this	this	DT
cord-277417-f71jwdzj	287	11	elongated	elongated	JJ
cord-277417-f71jwdzj	287	12	period	period	NN
cord-277417-f71jwdzj	287	13	of	of	IN
cord-277417-f71jwdzj	287	14	transmission	transmission	NN
cord-277417-f71jwdzj	287	15	in	in	IN
cord-277417-f71jwdzj	287	16	humans	human	NNS
cord-277417-f71jwdzj	287	17	may	may	MD
cord-277417-f71jwdzj	287	18	have	have	VB
cord-277417-f71jwdzj	287	19	resulted	result	VBN
cord-277417-f71jwdzj	287	20	in	in	IN
cord-277417-f71jwdzj	287	21	different	different	JJ
cord-277417-f71jwdzj	287	22	selection	selection	NN
cord-277417-f71jwdzj	287	23	pressures	pressure	NNS
cord-277417-f71jwdzj	287	24	from	from	IN
cord-277417-f71jwdzj	287	25	those	those	DT
cord-277417-f71jwdzj	287	26	faced	face	VBN
cord-277417-f71jwdzj	287	27	in	in	IN
cord-277417-f71jwdzj	287	28	the	the	DT
cord-277417-f71jwdzj	287	29	animal	animal	NN
cord-277417-f71jwdzj	287	30	reservoir	reservoir	NN
cord-277417-f71jwdzj	287	31	.	.	.
cord-277417-f71jwdzj	288	1	This	this	DT
cord-277417-f71jwdzj	288	2	outbreak	outbreak	NN
cord-277417-f71jwdzj	288	3	also	also	RB
cord-277417-f71jwdzj	288	4	raised	raise	VBD
cord-277417-f71jwdzj	288	5	key	key	JJ
cord-277417-f71jwdzj	288	6	questions	question	NNS
cord-277417-f71jwdzj	288	7	about	about	IN
cord-277417-f71jwdzj	288	8	virulence	virulence	NN
cord-277417-f71jwdzj	288	9	evolution	evolution	NN
cord-277417-f71jwdzj	288	10	,	,	,
cord-277417-f71jwdzj	288	11	particularly	particularly	RB
cord-277417-f71jwdzj	288	12	whether	whether	IN
cord-277417-f71jwdzj	288	13	natural	natural	JJ
cord-277417-f71jwdzj	288	14	selection	selection	NN
cord-277417-f71jwdzj	288	15	would	would	MD
cord-277417-f71jwdzj	288	16	have	have	VB
cord-277417-f71jwdzj	288	17	favoured	favour	VBN
cord-277417-f71jwdzj	288	18	EBOV	EBOV	NNP
cord-277417-f71jwdzj	288	19	variants	variant	NNS
cord-277417-f71jwdzj	288	20	causing	cause	VBG
cord-277417-f71jwdzj	288	21	higher	high	JJR
cord-277417-f71jwdzj	288	22	or	or	CC
cord-277417-f71jwdzj	288	23	lower	low	JJR
cord-277417-f71jwdzj	288	24	human	human	JJ
cord-277417-f71jwdzj	288	25	case	case	NN
cord-277417-f71jwdzj	288	26	fatality	fatality	NN
cord-277417-f71jwdzj	288	27	rates	rate	NNS
cord-277417-f71jwdzj	288	28	had	have	VBD
cord-277417-f71jwdzj	288	29	the	the	DT
cord-277417-f71jwdzj	288	30	virus	virus	NN
cord-277417-f71jwdzj	288	31	not	not	RB
cord-277417-f71jwdzj	288	32	been	be	VBN
cord-277417-f71jwdzj	288	33	stamped	stamp	VBN
cord-277417-f71jwdzj	288	34	out	out	RP
cord-277417-f71jwdzj	288	35	by	by	IN
cord-277417-f71jwdzj	288	36	public	public	JJ
cord-277417-f71jwdzj	288	37	health	health	NN
cord-277417-f71jwdzj	288	38	intervention	intervention	NN
cord-277417-f71jwdzj	288	39	115	115	CD
cord-277417-f71jwdzj	288	40	.	.	.
cord-277417-f71jwdzj	289	1	Phylogenetic	phylogenetic	JJ
cord-277417-f71jwdzj	289	2	analysis	analysis	NN
cord-277417-f71jwdzj	289	3	of	of	IN
cord-277417-f71jwdzj	289	4	EBOV	EBOV	NNP
cord-277417-f71jwdzj	289	5	during	during	IN
cord-277417-f71jwdzj	289	6	the	the	DT
cord-277417-f71jwdzj	289	7	2013	2013	CD
cord-277417-f71jwdzj	289	8	-	-	SYM
cord-277417-f71jwdzj	289	9	2016	2016	CD
cord-277417-f71jwdzj	289	10	outbreak	outbreak	NN
cord-277417-f71jwdzj	289	11	revealed	reveal	VBD
cord-277417-f71jwdzj	289	12	an	an	DT
cord-277417-f71jwdzj	289	13	Ala82Val	Ala82Val	NNP
cord-277417-f71jwdzj	289	14	(	(	-LRB-
cord-277417-f71jwdzj	289	15	A82V	A82V	NNP
cord-277417-f71jwdzj	289	16	)	)	-RRB-
cord-277417-f71jwdzj	289	17	substitution	substitution	NN
cord-277417-f71jwdzj	289	18	in	in	IN
cord-277417-f71jwdzj	289	19	the	the	DT
cord-277417-f71jwdzj	289	20	virus	virus	NN
cord-277417-f71jwdzj	289	21	glycoprotein	glycoprotein	NN
cord-277417-f71jwdzj	289	22	to	to	TO
cord-277417-f71jwdzj	289	23	be	be	VB
cord-277417-f71jwdzj	289	24	of	of	IN
cord-277417-f71jwdzj	289	25	particular	particular	JJ
cord-277417-f71jwdzj	289	26	importance	importance	NN
cord-277417-f71jwdzj	289	27	70	70	CD
cord-277417-f71jwdzj	289	28	,	,	,
cord-277417-f71jwdzj	289	29	116	116	CD
cord-277417-f71jwdzj	289	30	.	.	.
cord-277417-f71jwdzj	290	1	A82V	A82V	NNP
cord-277417-f71jwdzj	290	2	is	be	VBZ
cord-277417-f71jwdzj	290	3	notable	notable	JJ
cord-277417-f71jwdzj	290	4	as	as	IN
cord-277417-f71jwdzj	290	5	it	-PRON-	PRP
cord-277417-f71jwdzj	290	6	falls	fall	VBZ
cord-277417-f71jwdzj	290	7	on	on	IN
cord-277417-f71jwdzj	290	8	a	a	DT
cord-277417-f71jwdzj	290	9	deep	deep	JJ
cord-277417-f71jwdzj	290	10	internal	internal	JJ
cord-277417-f71jwdzj	290	11	branch	branch	NN
cord-277417-f71jwdzj	290	12	of	of	IN
cord-277417-f71jwdzj	290	13	the	the	DT
cord-277417-f71jwdzj	290	14	EBOV	EBOV	NNP
cord-277417-f71jwdzj	290	15	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	290	16	,	,	,
cord-277417-f71jwdzj	290	17	compatible	compatible	JJ
cord-277417-f71jwdzj	290	18	with	with	IN
cord-277417-f71jwdzj	290	19	adaptive	adaptive	JJ
cord-277417-f71jwdzj	290	20	evolution	evolution	NN
cord-277417-f71jwdzj	290	21	,	,	,
cord-277417-f71jwdzj	290	22	whereas	whereas	IN
cord-277417-f71jwdzj	290	23	other	other	JJ
cord-277417-f71jwdzj	290	24	amino	amino	NN
cord-277417-f71jwdzj	290	25	acid	acid	NN
cord-277417-f71jwdzj	290	26	changes	change	NNS
cord-277417-f71jwdzj	290	27	are	be	VBP
cord-277417-f71jwdzj	290	28	associated	associate	VBN
cord-277417-f71jwdzj	290	29	with	with	IN
cord-277417-f71jwdzj	290	30	individual	individual	JJ
cord-277417-f71jwdzj	290	31	or	or	CC
cord-277417-f71jwdzj	290	32	only	only	JJ
cord-277417-f71jwdzj	290	33	small	small	JJ
cord-277417-f71jwdzj	290	34	clusters	cluster	NNS
cord-277417-f71jwdzj	290	35	of	of	IN
cord-277417-f71jwdzj	290	36	sequences	sequence	NNS
cord-277417-f71jwdzj	290	37	.	.	.
cord-277417-f71jwdzj	291	1	Moreover	moreover	RB
cord-277417-f71jwdzj	291	2	,	,	,
cord-277417-f71jwdzj	291	3	A82V	A82V	NNP
cord-277417-f71jwdzj	291	4	improves	improve	VBZ
cord-277417-f71jwdzj	291	5	binding	bind	VBG
cord-277417-f71jwdzj	291	6	to	to	IN
cord-277417-f71jwdzj	291	7	the	the	DT
cord-277417-f71jwdzj	291	8	human	human	JJ
cord-277417-f71jwdzj	291	9	NPC1	NPC1	NNP
cord-277417-f71jwdzj	291	10	receptor	receptor	NN
cord-277417-f71jwdzj	291	11	utilized	utilize	VBN
cord-277417-f71jwdzj	291	12	by	by	IN
cord-277417-f71jwdzj	291	13	EBOV	EBOV	NNP
cord-277417-f71jwdzj	291	14	117	117	CD
cord-277417-f71jwdzj	291	15	,	,	,
cord-277417-f71jwdzj	291	16	which	which	WDT
cord-277417-f71jwdzj	291	17	would	would	MD
cord-277417-f71jwdzj	291	18	increase	increase	VB
cord-277417-f71jwdzj	291	19	infectivity	infectivity	NN
cord-277417-f71jwdzj	291	20	in	in	IN
cord-277417-f71jwdzj	291	21	humans	human	NNS
cord-277417-f71jwdzj	291	22	,	,	,
cord-277417-f71jwdzj	291	23	at	at	IN
cord-277417-f71jwdzj	291	24	the	the	DT
cord-277417-f71jwdzj	291	25	same	same	JJ
cord-277417-f71jwdzj	291	26	time	time	NN
cord-277417-f71jwdzj	291	27	reducing	reduce	VBG
cord-277417-f71jwdzj	291	28	infectivity	infectivity	NN
cord-277417-f71jwdzj	291	29	in	in	IN
cord-277417-f71jwdzj	291	30	cells	cell	NNS
cord-277417-f71jwdzj	291	31	from	from	IN
cord-277417-f71jwdzj	291	32	the	the	DT
cord-277417-f71jwdzj	291	33	bat	bat	NN
cord-277417-f71jwdzj	291	34	reservoir	reservoir	NN
cord-277417-f71jwdzj	291	35	species	specie	VBZ
cord-277417-f71jwdzj	291	36	70	70	CD
cord-277417-f71jwdzj	291	37	,	,	,
cord-277417-f71jwdzj	291	38	116	116	CD
cord-277417-f71jwdzj	291	39	.	.	.
cord-277417-f71jwdzj	292	1	Intriguingly	intriguingly	RB
cord-277417-f71jwdzj	292	2	,	,	,
cord-277417-f71jwdzj	292	3	the	the	DT
cord-277417-f71jwdzj	292	4	appearance	appearance	NN
cord-277417-f71jwdzj	292	5	of	of	IN
cord-277417-f71jwdzj	292	6	A82V	A82V	NNP
cord-277417-f71jwdzj	292	7	on	on	IN
cord-277417-f71jwdzj	292	8	the	the	DT
cord-277417-f71jwdzj	292	9	EBOV	EBOV	NNP
cord-277417-f71jwdzj	292	10	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	292	11	is	be	VBZ
cord-277417-f71jwdzj	292	12	associated	associate	VBN
cord-277417-f71jwdzj	292	13	with	with	IN
cord-277417-f71jwdzj	292	14	two	two	CD
cord-277417-f71jwdzj	292	15	key	key	JJ
cord-277417-f71jwdzj	292	16	epidemiological	epidemiological	JJ
cord-277417-f71jwdzj	292	17	features	feature	NNS
cord-277417-f71jwdzj	292	18	:	:	:
cord-277417-f71jwdzj	292	19	an	an	DT
cord-277417-f71jwdzj	292	20	increase	increase	NN
cord-277417-f71jwdzj	292	21	in	in	IN
cord-277417-f71jwdzj	292	22	case	case	NN
cord-277417-f71jwdzj	292	23	numbers	number	NNS
cord-277417-f71jwdzj	292	24	and	and	CC
cord-277417-f71jwdzj	292	25	an	an	DT
cord-277417-f71jwdzj	292	26	increase	increase	NN
cord-277417-f71jwdzj	292	27	in	in	IN
cord-277417-f71jwdzj	292	28	mortality	mortality	NN
cord-277417-f71jwdzj	292	29	(	(	-LRB-
cord-277417-f71jwdzj	292	30	FIg	FIg	NNS
cord-277417-f71jwdzj	292	31	.	.	.
cord-277417-f71jwdzj	293	1	4	4	LS
cord-277417-f71jwdzj	293	2	)	)	-RRB-
cord-277417-f71jwdzj	293	3	.	.	.
cord-277417-f71jwdzj	294	1	If	if	IN
cord-277417-f71jwdzj	294	2	there	there	EX
cord-277417-f71jwdzj	294	3	was	be	VBD
cord-277417-f71jwdzj	294	4	indeed	indeed	RB
cord-277417-f71jwdzj	294	5	an	an	DT
cord-277417-f71jwdzj	294	6	increase	increase	NN
cord-277417-f71jwdzj	294	7	in	in	IN
cord-277417-f71jwdzj	294	8	both	both	CC
cord-277417-f71jwdzj	294	9	EBOV	EBOV	NNP
cord-277417-f71jwdzj	294	10	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	294	11	and	and	CC
cord-277417-f71jwdzj	294	12	virulence	virulence	NN
cord-277417-f71jwdzj	294	13	,	,	,
cord-277417-f71jwdzj	294	14	then	then	RB
cord-277417-f71jwdzj	294	15	higher	high	JJR
cord-277417-f71jwdzj	294	16	virulence	virulence	NN
cord-277417-f71jwdzj	294	17	is	be	VBZ
cord-277417-f71jwdzj	294	18	likely	likely	JJ
cord-277417-f71jwdzj	294	19	to	to	TO
cord-277417-f71jwdzj	294	20	have	have	VB
cord-277417-f71jwdzj	294	21	directly	directly	RB
cord-277417-f71jwdzj	294	22	increased	increase	VBN
cord-277417-f71jwdzj	294	23	viral	viral	JJ
cord-277417-f71jwdzj	294	24	fitness	fitness	NN
cord-277417-f71jwdzj	294	25	,	,	,
cord-277417-f71jwdzj	294	26	and	and	CC
cord-277417-f71jwdzj	294	27	in	in	IN
cord-277417-f71jwdzj	294	28	the	the	DT
cord-277417-f71jwdzj	294	29	absence	absence	NN
cord-277417-f71jwdzj	294	30	of	of	IN
cord-277417-f71jwdzj	294	31	an	an	DT
cord-277417-f71jwdzj	294	32	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	294	33	trade	trade	NN
cord-277417-f71jwdzj	294	34	-	-	HYPH
cord-277417-f71jwdzj	294	35	off	off	NN
cord-277417-f71jwdzj	294	36	as	as	RB
cord-277417-f71jwdzj	294	37	only	only	RB
cord-277417-f71jwdzj	294	38	a	a	DT
cord-277417-f71jwdzj	294	39	single	single	JJ
cord-277417-f71jwdzj	294	40	substitution	substitution	NN
cord-277417-f71jwdzj	294	41	was	be	VBD
cord-277417-f71jwdzj	294	42	identified	identify	VBN
cord-277417-f71jwdzj	294	43	.	.	.
cord-277417-f71jwdzj	295	1	However	however	RB
cord-277417-f71jwdzj	295	2	,	,	,
cord-277417-f71jwdzj	295	3	these	these	DT
cord-277417-f71jwdzj	295	4	apparent	apparent	JJ
cord-277417-f71jwdzj	295	5	changes	change	NNS
cord-277417-f71jwdzj	295	6	in	in	IN
cord-277417-f71jwdzj	295	7	phenotype	phenotype	NN
cord-277417-f71jwdzj	295	8	also	also	RB
cord-277417-f71jwdzj	295	9	coincided	coincide	VBD
cord-277417-f71jwdzj	295	10	with	with	IN
cord-277417-f71jwdzj	295	11	the	the	DT
cord-277417-f71jwdzj	295	12	movement	movement	NN
cord-277417-f71jwdzj	295	13	of	of	IN
cord-277417-f71jwdzj	295	14	the	the	DT
cord-277417-f71jwdzj	295	15	virus	virus	NN
cord-277417-f71jwdzj	295	16	from	from	IN
cord-277417-f71jwdzj	295	17	Guinea	Guinea	NNP
cord-277417-f71jwdzj	295	18	to	to	IN
cord-277417-f71jwdzj	295	19	Sierra	Sierra	NNP
cord-277417-f71jwdzj	295	20	Leone	Leone	NNP
cord-277417-f71jwdzj	295	21	,	,	,
cord-277417-f71jwdzj	295	22	such	such	JJ
cord-277417-f71jwdzj	295	23	that	that	IN
cord-277417-f71jwdzj	295	24	any	any	DT
cord-277417-f71jwdzj	295	25	change	change	NN
cord-277417-f71jwdzj	295	26	in	in	IN
cord-277417-f71jwdzj	295	27	case	case	NN
cord-277417-f71jwdzj	295	28	numbers	number	NNS
cord-277417-f71jwdzj	295	29	and	and	CC
cord-277417-f71jwdzj	295	30	mortality	mortality	NN
cord-277417-f71jwdzj	295	31	could	could	MD
cord-277417-f71jwdzj	295	32	in	in	IN
cord-277417-f71jwdzj	295	33	fact	fact	NN
cord-277417-f71jwdzj	295	34	be	be	VB
cord-277417-f71jwdzj	295	35	due	due	JJ
cord-277417-f71jwdzj	295	36	to	to	IN
cord-277417-f71jwdzj	295	37	a	a	DT
cord-277417-f71jwdzj	295	38	change	change	NN
cord-277417-f71jwdzj	295	39	in	in	IN
cord-277417-f71jwdzj	295	40	epidemiological	epidemiological	JJ
cord-277417-f71jwdzj	295	41	factors	factor	NNS
cord-277417-f71jwdzj	295	42	(	(	-LRB-
cord-277417-f71jwdzj	295	43	such	such	JJ
cord-277417-f71jwdzj	295	44	as	as	IN
cord-277417-f71jwdzj	295	45	access	access	NN
cord-277417-f71jwdzj	295	46	to	to	IN
cord-277417-f71jwdzj	295	47	health	health	NN
cord-277417-f71jwdzj	295	48	care	care	NN
cord-277417-f71jwdzj	295	49	or	or	CC
cord-277417-f71jwdzj	295	50	differing	differ	VBG
cord-277417-f71jwdzj	295	51	human	human	JJ
cord-277417-f71jwdzj	295	52	demographics	demographic	NNS
cord-277417-f71jwdzj	295	53	and/or	and/or	CC
cord-277417-f71jwdzj	295	54	transmission	transmission	NN
cord-277417-f71jwdzj	295	55	networks	network	NNS
cord-277417-f71jwdzj	295	56	)	)	-RRB-
cord-277417-f71jwdzj	295	57	,	,	,
cord-277417-f71jwdzj	295	58	and	and	CC
cord-277417-f71jwdzj	295	59	recent	recent	JJ
cord-277417-f71jwdzj	295	60	studies	study	NNS
cord-277417-f71jwdzj	295	61	using	use	VBG
cord-277417-f71jwdzj	295	62	animal	animal	NN
cord-277417-f71jwdzj	295	63	models	model	NNS
cord-277417-f71jwdzj	295	64	suggest	suggest	VBP
cord-277417-f71jwdzj	295	65	that	that	IN
cord-277417-f71jwdzj	295	66	A82V	A82V	NNP
cord-277417-f71jwdzj	295	67	has	have	VBZ
cord-277417-f71jwdzj	295	68	no	no	DT
cord-277417-f71jwdzj	295	69	direct	direct	JJ
cord-277417-f71jwdzj	295	70	impact	impact	NN
cord-277417-f71jwdzj	295	71	on	on	IN
cord-277417-f71jwdzj	295	72	virulence	virulence	NN
cord-277417-f71jwdzj	295	73	118	118	CD
cord-277417-f71jwdzj	295	74	.	.	.
cord-277417-f71jwdzj	296	1	ZIKV	ZIKV	NNP
cord-277417-f71jwdzj	296	2	is	be	VBZ
cord-277417-f71jwdzj	296	3	the	the	DT
cord-277417-f71jwdzj	296	4	most	most	RBS
cord-277417-f71jwdzj	296	5	recent	recent	JJ
cord-277417-f71jwdzj	296	6	emerging	emerge	VBG
cord-277417-f71jwdzj	296	7	virus	virus	NN
cord-277417-f71jwdzj	296	8	to	to	TO
cord-277417-f71jwdzj	296	9	lead	lead	VB
cord-277417-f71jwdzj	296	10	to	to	IN
cord-277417-f71jwdzj	296	11	a	a	DT
cord-277417-f71jwdzj	296	12	major	major	JJ
cord-277417-f71jwdzj	296	13	public	public	JJ
cord-277417-f71jwdzj	296	14	health	health	NN
cord-277417-f71jwdzj	296	15	scare	scare	NN
cord-277417-f71jwdzj	296	16	and	and	CC
cord-277417-f71jwdzj	296	17	is	be	VBZ
cord-277417-f71jwdzj	296	18	puzzling	puzzle	VBG
cord-277417-f71jwdzj	296	19	because	because	IN
cord-277417-f71jwdzj	296	20	a	a	DT
cord-277417-f71jwdzj	296	21	seemingly	seemingly	RB
cord-277417-f71jwdzj	296	22	benign	benign	JJ
cord-277417-f71jwdzj	296	23	virus	virus	NN
cord-277417-f71jwdzj	296	24	suddenly	suddenly	RB
cord-277417-f71jwdzj	296	25	increased	increase	VBD
cord-277417-f71jwdzj	296	26	in	in	IN
cord-277417-f71jwdzj	296	27	virulence	virulence	NN
cord-277417-f71jwdzj	296	28	,	,	,
cord-277417-f71jwdzj	296	29	causing	cause	VBG
cord-277417-f71jwdzj	296	30	severe	severe	JJ
cord-277417-f71jwdzj	296	31	neurological	neurological	JJ
cord-277417-f71jwdzj	296	32	disease	disease	NN
cord-277417-f71jwdzj	296	33	in	in	IN
cord-277417-f71jwdzj	296	34	humans	human	NNS
cord-277417-f71jwdzj	296	35	.	.	.
cord-277417-f71jwdzj	297	1	Before	before	IN
cord-277417-f71jwdzj	297	2	2007	2007	CD
cord-277417-f71jwdzj	297	3	,	,	,
cord-277417-f71jwdzj	297	4	there	there	EX
cord-277417-f71jwdzj	297	5	were	be	VBD
cord-277417-f71jwdzj	297	6	fewer	few	JJR
cord-277417-f71jwdzj	297	7	than	than	IN
cord-277417-f71jwdzj	297	8	20	20	CD
cord-277417-f71jwdzj	297	9	human	human	JJ
cord-277417-f71jwdzj	297	10	cases	case	NNS
cord-277417-f71jwdzj	297	11	of	of	IN
cord-277417-f71jwdzj	297	12	ZIKV	ZIKV	NNP
cord-277417-f71jwdzj	297	13	reported	report	VBD
cord-277417-f71jwdzj	297	14	and	and	CC
cord-277417-f71jwdzj	297	15	all	all	DT
cord-277417-f71jwdzj	297	16	were	be	VBD
cord-277417-f71jwdzj	297	17	mild	mild	JJ
cord-277417-f71jwdzj	297	18	infections	infection	NNS
cord-277417-f71jwdzj	297	19	restricted	restrict	VBN
cord-277417-f71jwdzj	297	20	to	to	IN
cord-277417-f71jwdzj	297	21	Africa	Africa	NNP
cord-277417-f71jwdzj	297	22	and	and	CC
cord-277417-f71jwdzj	297	23	Asia	Asia	NNP
cord-277417-f71jwdzj	297	24	9,119	9,119	CD
cord-277417-f71jwdzj	297	25	.	.	.
cord-277417-f71jwdzj	298	1	Consequently	consequently	RB
cord-277417-f71jwdzj	298	2	,	,	,
cord-277417-f71jwdzj	298	3	neither	neither	CC
cord-277417-f71jwdzj	298	4	the	the	DT
cord-277417-f71jwdzj	298	5	disease	disease	NN
cord-277417-f71jwdzj	298	6	caused	cause	VBN
cord-277417-f71jwdzj	298	7	by	by	IN
cord-277417-f71jwdzj	298	8	ZIKV	ZIKV	NNP
cord-277417-f71jwdzj	298	9	nor	nor	CC
cord-277417-f71jwdzj	298	10	the	the	DT
cord-277417-f71jwdzj	298	11	molecular	molecular	JJ
cord-277417-f71jwdzj	298	12	determinants	determinant	NNS
cord-277417-f71jwdzj	298	13	of	of	IN
cord-277417-f71jwdzj	298	14	ZIKV	ZIKV	NNP
cord-277417-f71jwdzj	298	15	virulence	virulence	NN
cord-277417-f71jwdzj	298	16	were	be	VBD
cord-277417-f71jwdzj	298	17	well	well	RB
cord-277417-f71jwdzj	298	18	characterized	characterize	VBN
cord-277417-f71jwdzj	298	19	,	,	,
cord-277417-f71jwdzj	298	20	and	and	CC
cord-277417-f71jwdzj	298	21	it	-PRON-	PRP
cord-277417-f71jwdzj	298	22	is	be	VBZ
cord-277417-f71jwdzj	298	23	likely	likely	JJ
cord-277417-f71jwdzj	298	24	that	that	IN
cord-277417-f71jwdzj	298	25	there	there	EX
cord-277417-f71jwdzj	298	26	was	be	VBD
cord-277417-f71jwdzj	298	27	systematic	systematic	JJ
cord-277417-f71jwdzj	298	28	under	under	IN
cord-277417-f71jwdzj	298	29	-	-	HYPH
cord-277417-f71jwdzj	298	30	reporting	reporting	NN
cord-277417-f71jwdzj	298	31	of	of	IN
cord-277417-f71jwdzj	298	32	infections	infection	NNS
cord-277417-f71jwdzj	298	33	,	,	,
cord-277417-f71jwdzj	298	34	including	include	VBG
cord-277417-f71jwdzj	298	35	those	those	DT
cord-277417-f71jwdzj	298	36	associated	associate	VBN
cord-277417-f71jwdzj	298	37	with	with	IN
cord-277417-f71jwdzj	298	38	severe	severe	JJ
cord-277417-f71jwdzj	298	39	disease	disease	NN
cord-277417-f71jwdzj	298	40	.	.	.
cord-277417-f71jwdzj	299	1	In	in	IN
cord-277417-f71jwdzj	299	2	2007	2007	CD
cord-277417-f71jwdzj	299	3	,	,	,
cord-277417-f71jwdzj	299	4	the	the	DT
cord-277417-f71jwdzj	299	5	Pacific	Pacific	NNP
cord-277417-f71jwdzj	299	6	Islands	Islands	NNPS
cord-277417-f71jwdzj	299	7	reported	report	VBD
cord-277417-f71jwdzj	299	8	the	the	DT
cord-277417-f71jwdzj	299	9	first	first	JJ
cord-277417-f71jwdzj	299	10	major	major	JJ
cord-277417-f71jwdzj	299	11	outbreaks	outbreak	NNS
cord-277417-f71jwdzj	299	12	of	of	IN
cord-277417-f71jwdzj	299	13	ZIKV	ZIKV	NNP
cord-277417-f71jwdzj	299	14	before	before	IN
cord-277417-f71jwdzj	299	15	the	the	DT
cord-277417-f71jwdzj	299	16	virus	virus	NN
cord-277417-f71jwdzj	299	17	spread	spread	VBD
cord-277417-f71jwdzj	299	18	to	to	IN
cord-277417-f71jwdzj	299	19	the	the	DT
cord-277417-f71jwdzj	299	20	Americas	Americas	NNPS
cord-277417-f71jwdzj	299	21	in	in	IN
cord-277417-f71jwdzj	299	22	2014	2014	CD
cord-277417-f71jwdzj	299	23	.	.	.
cord-277417-f71jwdzj	300	1	Although	although	IN
cord-277417-f71jwdzj	300	2	the	the	DT
cord-277417-f71jwdzj	300	3	majority	majority	NN
cord-277417-f71jwdzj	300	4	of	of	IN
cord-277417-f71jwdzj	300	5	human	human	JJ
cord-277417-f71jwdzj	300	6	infections	infection	NNS
cord-277417-f71jwdzj	300	7	range	range	VBP
cord-277417-f71jwdzj	300	8	from	from	IN
cord-277417-f71jwdzj	300	9	asymptomatic	asymptomatic	JJ
cord-277417-f71jwdzj	300	10	to	to	IN
cord-277417-f71jwdzj	300	11	mild	mild	JJ
cord-277417-f71jwdzj	300	12	,	,	,
cord-277417-f71jwdzj	300	13	the	the	DT
cord-277417-f71jwdzj	300	14	virus	virus	NN
cord-277417-f71jwdzj	300	15	was	be	VBD
cord-277417-f71jwdzj	300	16	associated	associate	VBN
cord-277417-f71jwdzj	300	17	with	with	IN
cord-277417-f71jwdzj	300	18	the	the	DT
cord-277417-f71jwdzj	300	19	neurological	neurological	JJ
cord-277417-f71jwdzj	300	20	Guillain	Guillain	NNP
cord-277417-f71jwdzj	300	21	-	-	HYPH
cord-277417-f71jwdzj	300	22	Barré	Barré	NNP
cord-277417-f71jwdzj	300	23	syndrome	syndrome	NN
cord-277417-f71jwdzj	300	24	in	in	IN
cord-277417-f71jwdzj	300	25	French	French	NNP
cord-277417-f71jwdzj	300	26	Polynesia	Polynesia	NNP
cord-277417-f71jwdzj	300	27	in	in	IN
cord-277417-f71jwdzj	300	28	2013	2013	CD
cord-277417-f71jwdzj	300	29	(	(	-LRB-
cord-277417-f71jwdzj	300	30	ReF.	ReF.	NNP
cord-277417-f71jwdzj	300	31	120	120	CD
cord-277417-f71jwdzj	300	32	)	)	-RRB-
cord-277417-f71jwdzj	300	33	,	,	,
cord-277417-f71jwdzj	300	34	and	and	CC
cord-277417-f71jwdzj	300	35	those	those	DT
cord-277417-f71jwdzj	300	36	cases	case	NNS
cord-277417-f71jwdzj	300	37	from	from	IN
cord-277417-f71jwdzj	300	38	the	the	DT
cord-277417-f71jwdzj	300	39	Americas	Americas	NNPS
cord-277417-f71jwdzj	300	40	,	,	,
cord-277417-f71jwdzj	300	41	particularly	particularly	RB
cord-277417-f71jwdzj	300	42	Brazil	Brazil	NNP
cord-277417-f71jwdzj	300	43	,	,	,
cord-277417-f71jwdzj	300	44	were	be	VBD
cord-277417-f71jwdzj	300	45	linked	link	VBN
cord-277417-f71jwdzj	300	46	to	to	IN
cord-277417-f71jwdzj	300	47	more	more	JJR
cord-277417-f71jwdzj	300	48	severe	severe	JJ
cord-277417-f71jwdzj	300	49	diseases	disease	NNS
cord-277417-f71jwdzj	300	50	,	,	,
cord-277417-f71jwdzj	300	51	including	include	VBG
cord-277417-f71jwdzj	300	52	congenital	congenital	JJ
cord-277417-f71jwdzj	300	53	abnormalities	abnormality	NNS
cord-277417-f71jwdzj	300	54	such	such	JJ
cord-277417-f71jwdzj	300	55	as	as	IN
cord-277417-f71jwdzj	300	56	microcephaly	microcephaly	NNS
cord-277417-f71jwdzj	300	57	121	121	CD
cord-277417-f71jwdzj	300	58	.	.	.
cord-277417-f71jwdzj	301	1	Phylogenetic	phylogenetic	JJ
cord-277417-f71jwdzj	301	2	analysis	analysis	NN
cord-277417-f71jwdzj	301	3	revealed	reveal	VBD
cord-277417-f71jwdzj	301	4	that	that	IN
cord-277417-f71jwdzj	301	5	the	the	DT
cord-277417-f71jwdzj	301	6	most	most	RBS
cord-277417-f71jwdzj	301	7	recent	recent	JJ
cord-277417-f71jwdzj	301	8	Zika	Zika	NNP
cord-277417-f71jwdzj	301	9	epidemics	epidemic	NNS
cord-277417-f71jwdzj	301	10	are	be	VBP
cord-277417-f71jwdzj	301	11	due	due	JJ
cord-277417-f71jwdzj	301	12	to	to	IN
cord-277417-f71jwdzj	301	13	the	the	DT
cord-277417-f71jwdzj	301	14	Asian	asian	JJ
cord-277417-f71jwdzj	301	15	lineage	lineage	NN
cord-277417-f71jwdzj	301	16	of	of	IN
cord-277417-f71jwdzj	301	17	ZIKV	ZIKV	NNP
cord-277417-f71jwdzj	301	18	,	,	,
cord-277417-f71jwdzj	301	19	rather	rather	RB
cord-277417-f71jwdzj	301	20	than	than	IN
cord-277417-f71jwdzj	301	21	the	the	DT
cord-277417-f71jwdzj	301	22	African	african	JJ
cord-277417-f71jwdzj	301	23	lineage	lineage	NN
cord-277417-f71jwdzj	301	24	122	122	CD
cord-277417-f71jwdzj	301	25	,	,	,
cord-277417-f71jwdzj	301	26	and	and	CC
cord-277417-f71jwdzj	301	27	that	that	IN
cord-277417-f71jwdzj	301	28	the	the	DT
cord-277417-f71jwdzj	301	29	virus	virus	NN
cord-277417-f71jwdzj	301	30	spread	spread	VBD
cord-277417-f71jwdzj	301	31	cryptically	cryptically	RB
cord-277417-f71jwdzj	301	32	in	in	IN
cord-277417-f71jwdzj	301	33	Brazil	Brazil	NNP
cord-277417-f71jwdzj	301	34	for	for	IN
cord-277417-f71jwdzj	301	35	at	at	IN
cord-277417-f71jwdzj	301	36	least	least	JJS
cord-277417-f71jwdzj	301	37	a	a	DT
cord-277417-f71jwdzj	301	38	year	year	NN
cord-277417-f71jwdzj	301	39	before	before	IN
cord-277417-f71jwdzj	301	40	its	-PRON-	PRP$
cord-277417-f71jwdzj	301	41	detection	detection	NN
cord-277417-f71jwdzj	301	42	20	20	CD
cord-277417-f71jwdzj	301	43	.	.	.
cord-277417-f71jwdzj	302	1	Although	although	IN
cord-277417-f71jwdzj	302	2	there	there	EX
cord-277417-f71jwdzj	302	3	are	be	VBP
cord-277417-f71jwdzj	302	4	multiple	multiple	JJ
cord-277417-f71jwdzj	302	5	amino	amino	NN
cord-277417-f71jwdzj	302	6	acid	acid	NN
cord-277417-f71jwdzj	302	7	differences	difference	NNS
cord-277417-f71jwdzj	302	8	between	between	IN
cord-277417-f71jwdzj	302	9	the	the	DT
cord-277417-f71jwdzj	302	10	African	african	JJ
cord-277417-f71jwdzj	302	11	and	and	CC
cord-277417-f71jwdzj	302	12	Asian	asian	JJ
cord-277417-f71jwdzj	302	13	lineages	lineage	NNS
cord-277417-f71jwdzj	302	14	122	122	CD
cord-277417-f71jwdzj	302	15	,	,	,
cord-277417-f71jwdzj	302	16	123	123	CD
cord-277417-f71jwdzj	302	17	,	,	,
cord-277417-f71jwdzj	302	18	it	-PRON-	PRP
cord-277417-f71jwdzj	302	19	has	have	VBZ
cord-277417-f71jwdzj	302	20	been	be	VBN
cord-277417-f71jwdzj	302	21	claimed	claim	VBN
cord-277417-f71jwdzj	302	22	that	that	IN
cord-277417-f71jwdzj	302	23	those	those	DT
cord-277417-f71jwdzj	302	24	in	in	IN
cord-277417-f71jwdzj	302	25	the	the	DT
cord-277417-f71jwdzj	302	26	Asian	asian	JJ
cord-277417-f71jwdzj	302	27	lineage	lineage	NN
cord-277417-f71jwdzj	302	28	that	that	WDT
cord-277417-f71jwdzj	302	29	spread	spread	VBD
cord-277417-f71jwdzj	302	30	through	through	IN
cord-277417-f71jwdzj	302	31	the	the	DT
cord-277417-f71jwdzj	302	32	Americas	Americas	NNPS
cord-277417-f71jwdzj	302	33	may	may	MD
cord-277417-f71jwdzj	302	34	be	be	VB
cord-277417-f71jwdzj	302	35	directly	directly	RB
cord-277417-f71jwdzj	302	36	linked	link	VBN
cord-277417-f71jwdzj	302	37	to	to	IN
cord-277417-f71jwdzj	302	38	both	both	CC
cord-277417-f71jwdzj	302	39	increased	increase	VBN
cord-277417-f71jwdzj	302	40	infectivity	infectivity	NN
cord-277417-f71jwdzj	302	41	in	in	IN
cord-277417-f71jwdzj	302	42	Aedes	Aedes	NNP
cord-277417-f71jwdzj	302	43	aegypti	aegypti	NN
cord-277417-f71jwdzj	302	44	mosquitoes	mosquitoe	VBZ
cord-277417-f71jwdzj	302	45	124	124	CD
cord-277417-f71jwdzj	302	46	and	and	CC
cord-277417-f71jwdzj	302	47	microcephaly	microcephaly	NNS
cord-277417-f71jwdzj	302	48	,	,	,
cord-277417-f71jwdzj	302	49	most	most	RBS
cord-277417-f71jwdzj	302	50	notably	notably	RB
cord-277417-f71jwdzj	302	51	a	a	DT
cord-277417-f71jwdzj	302	52	Ser139Asn	ser139asn	NN
cord-277417-f71jwdzj	302	53	(	(	-LRB-
cord-277417-f71jwdzj	302	54	S139N	s139n	NN
cord-277417-f71jwdzj	302	55	)	)	-RRB-
cord-277417-f71jwdzj	302	56	amino	amino	NN
cord-277417-f71jwdzj	302	57	acid	acid	NN
cord-277417-f71jwdzj	302	58	change	change	NN
cord-277417-f71jwdzj	302	59	in	in	IN
cord-277417-f71jwdzj	302	60	the	the	DT
cord-277417-f71jwdzj	302	61	PrM	PrM	NNP
cord-277417-f71jwdzj	302	62	protein	protein	NNP
cord-277417-f71jwdzj	302	63	125	125	CD
cord-277417-f71jwdzj	302	64	.	.	.
cord-277417-f71jwdzj	303	1	However	however	RB
cord-277417-f71jwdzj	303	2	,	,	,
cord-277417-f71jwdzj	303	3	there	there	EX
cord-277417-f71jwdzj	303	4	is	be	VBZ
cord-277417-f71jwdzj	303	5	still	still	RB
cord-277417-f71jwdzj	303	6	considerable	considerable	JJ
cord-277417-f71jwdzj	303	7	uncertainty	uncertainty	NN
cord-277417-f71jwdzj	303	8	in	in	IN
cord-277417-f71jwdzj	303	9	this	this	DT
cord-277417-f71jwdzj	303	10	area	area	NN
cord-277417-f71jwdzj	303	11	,	,	,
cord-277417-f71jwdzj	303	12	with	with	IN
cord-277417-f71jwdzj	303	13	others	other	NNS
cord-277417-f71jwdzj	303	14	arguing	argue	VBG
cord-277417-f71jwdzj	303	15	that	that	IN
cord-277417-f71jwdzj	303	16	viruses	virus	NNS
cord-277417-f71jwdzj	303	17	from	from	IN
cord-277417-f71jwdzj	303	18	both	both	DT
cord-277417-f71jwdzj	303	19	lineages	lineage	NNS
cord-277417-f71jwdzj	303	20	can	can	MD
cord-277417-f71jwdzj	303	21	cause	cause	VB
cord-277417-f71jwdzj	303	22	neurovirulence	neurovirulence	NNP
cord-277417-f71jwdzj	303	23	but	but	CC
cord-277417-f71jwdzj	303	24	that	that	IN
cord-277417-f71jwdzj	303	25	cases	case	NNS
cord-277417-f71jwdzj	303	26	often	often	RB
cord-277417-f71jwdzj	303	27	go	go	VBP
cord-277417-f71jwdzj	303	28	unreported	unreported	JJ
cord-277417-f71jwdzj	303	29	9	9	CD
cord-277417-f71jwdzj	303	30	,	,	,
cord-277417-f71jwdzj	303	31	126	126	CD
cord-277417-f71jwdzj	303	32	.	.	.
cord-277417-f71jwdzj	304	1	Hence	hence	RB
cord-277417-f71jwdzj	304	2	,	,	,
cord-277417-f71jwdzj	304	3	the	the	DT
cord-277417-f71jwdzj	304	4	case	case	NN
cord-277417-f71jwdzj	304	5	of	of	IN
cord-277417-f71jwdzj	304	6	ZIKV	ZIKV	NNP
cord-277417-f71jwdzj	304	7	highlights	highlight	VBZ
cord-277417-f71jwdzj	304	8	the	the	DT
cord-277417-f71jwdzj	304	9	difficulty	difficulty	NN
cord-277417-f71jwdzj	304	10	in	in	IN
cord-277417-f71jwdzj	304	11	assessing	assess	VBG
cord-277417-f71jwdzj	304	12	virulence	virulence	NN
cord-277417-f71jwdzj	304	13	evolution	evolution	NN
cord-277417-f71jwdzj	304	14	within	within	IN
cord-277417-f71jwdzj	304	15	a	a	DT
cord-277417-f71jwdzj	304	16	background	background	NN
cord-277417-f71jwdzj	304	17	of	of	IN
cord-277417-f71jwdzj	304	18	sparse	sparse	JJ
cord-277417-f71jwdzj	304	19	and	and	CC
cord-277417-f71jwdzj	304	20	biased	biased	JJ
cord-277417-f71jwdzj	304	21	sampling	sampling	NN
cord-277417-f71jwdzj	304	22	even	even	RB
cord-277417-f71jwdzj	304	23	with	with	IN
cord-277417-f71jwdzj	304	24	phylogenomic	phylogenomic	NNP
cord-277417-f71jwdzj	304	25	data	data	NNP
cord-277417-f71jwdzj	304	26	and	and	CC
cord-277417-f71jwdzj	304	27	shows	show	VBZ
cord-277417-f71jwdzj	304	28	the	the	DT
cord-277417-f71jwdzj	304	29	importance	importance	NN
cord-277417-f71jwdzj	304	30	of	of	IN
cord-277417-f71jwdzj	304	31	collecting	collect	VBG
cord-277417-f71jwdzj	304	32	reliable	reliable	JJ
cord-277417-f71jwdzj	304	33	,	,	,
cord-277417-f71jwdzj	304	34	real	real	JJ
cord-277417-f71jwdzj	304	35	-	-	HYPH
cord-277417-f71jwdzj	304	36	time	time	NN
cord-277417-f71jwdzj	304	37	epidemiological	epidemiological	JJ
cord-277417-f71jwdzj	304	38	data	datum	NNS
cord-277417-f71jwdzj	304	39	even	even	RB
cord-277417-f71jwdzj	304	40	in	in	IN
cord-277417-f71jwdzj	304	41	low	low	JJ
cord-277417-f71jwdzj	304	42	-	-	HYPH
cord-277417-f71jwdzj	304	43	incidence	incidence	NN
cord-277417-f71jwdzj	304	44	situations	situation	NNS
cord-277417-f71jwdzj	304	45	.	.	.
cord-277417-f71jwdzj	305	1	70	70	CD
cord-277417-f71jwdzj	305	2	,	,	,
cord-277417-f71jwdzj	305	3	116	116	CD
cord-277417-f71jwdzj	305	4	.	.	.
cord-277417-f71jwdzj	306	1	Maps	map	NNS
cord-277417-f71jwdzj	306	2	above	above	IN
cord-277417-f71jwdzj	306	3	the	the	DT
cord-277417-f71jwdzj	306	4	phylogeny	phylogeny	NN
cord-277417-f71jwdzj	306	5	show	show	VBP
cord-277417-f71jwdzj	306	6	the	the	DT
cord-277417-f71jwdzj	306	7	spread	spread	NN
cord-277417-f71jwdzj	306	8	of	of	IN
cord-277417-f71jwdzj	306	9	EBOV	EBOV	NNP
cord-277417-f71jwdzj	306	10	over	over	IN
cord-277417-f71jwdzj	306	11	the	the	DT
cord-277417-f71jwdzj	306	12	timeline	timeline	NN
cord-277417-f71jwdzj	306	13	of	of	IN
cord-277417-f71jwdzj	306	14	the	the	DT
cord-277417-f71jwdzj	306	15	outbreak	outbreak	NN
cord-277417-f71jwdzj	306	16	in	in	IN
cord-277417-f71jwdzj	306	17	the	the	DT
cord-277417-f71jwdzj	306	18	three	three	CD
cord-277417-f71jwdzj	306	19	affected	affected	JJ
cord-277417-f71jwdzj	306	20	countries	country	NNS
cord-277417-f71jwdzj	306	21	in	in	IN
cord-277417-f71jwdzj	306	22	West	West	NNP
cord-277417-f71jwdzj	306	23	Africa	Africa	NNP
cord-277417-f71jwdzj	306	24	,	,	,
cord-277417-f71jwdzj	306	25	where	where	WRB
cord-277417-f71jwdzj	306	26	blue	blue	JJ
cord-277417-f71jwdzj	306	27	-	-	HYPH
cord-277417-f71jwdzj	306	28	shaded	shade	VBN
cord-277417-f71jwdzj	306	29	regions	region	NNS
cord-277417-f71jwdzj	306	30	correspond	correspond	VBP
cord-277417-f71jwdzj	306	31	to	to	IN
cord-277417-f71jwdzj	306	32	the	the	DT
cord-277417-f71jwdzj	306	33	wild	wild	JJ
cord-277417-f71jwdzj	306	34	-	-	HYPH
cord-277417-f71jwdzj	306	35	type	type	NN
cord-277417-f71jwdzj	306	36	virus	virus	NN
cord-277417-f71jwdzj	306	37	variant	variant	NN
cord-277417-f71jwdzj	306	38	(	(	-LRB-
cord-277417-f71jwdzj	306	39	A82	A82	NNP
cord-277417-f71jwdzj	306	40	)	)	-RRB-
cord-277417-f71jwdzj	306	41	and	and	CC
cord-277417-f71jwdzj	306	42	redshaded	redshade	VBN
cord-277417-f71jwdzj	306	43	areas	area	NNS
cord-277417-f71jwdzj	306	44	correspond	correspond	VBP
cord-277417-f71jwdzj	306	45	to	to	IN
cord-277417-f71jwdzj	306	46	mutated	mutate	VBN
cord-277417-f71jwdzj	306	47	virus	virus	NN
cord-277417-f71jwdzj	306	48	variant	variant	NN
cord-277417-f71jwdzj	306	49	(	(	-LRB-
cord-277417-f71jwdzj	306	50	V82	V82	NNP
cord-277417-f71jwdzj	306	51	)	)	-RRB-
cord-277417-f71jwdzj	306	52	.	.	.
cord-277417-f71jwdzj	307	1	It	-PRON-	PRP
cord-277417-f71jwdzj	307	2	is	be	VBZ
cord-277417-f71jwdzj	307	3	possible	possible	JJ
cord-277417-f71jwdzj	307	4	that	that	IN
cord-277417-f71jwdzj	307	5	A82V	A82V	NNP
cord-277417-f71jwdzj	307	6	was	be	VBD
cord-277417-f71jwdzj	307	7	also	also	RB
cord-277417-f71jwdzj	307	8	associated	associate	VBN
cord-277417-f71jwdzj	307	9	with	with	IN
cord-277417-f71jwdzj	307	10	an	an	DT
cord-277417-f71jwdzj	307	11	increase	increase	NN
cord-277417-f71jwdzj	307	12	in	in	IN
cord-277417-f71jwdzj	307	13	both	both	CC
cord-277417-f71jwdzj	307	14	EBOV	EBOV	NNP
cord-277417-f71jwdzj	307	15	case	case	NN
cord-277417-f71jwdzj	307	16	numbers	number	NNS
cord-277417-f71jwdzj	307	17	and	and	CC
cord-277417-f71jwdzj	307	18	mortality	mortality	NN
cord-277417-f71jwdzj	307	19	(	(	-LRB-
cord-277417-f71jwdzj	307	20	that	that	RB
cord-277417-f71jwdzj	307	21	is	is	RB
cord-277417-f71jwdzj	307	22	,	,	,
cord-277417-f71jwdzj	307	23	virulence	virulence	NN
cord-277417-f71jwdzj	307	24	)	)	-RRB-
cord-277417-f71jwdzj	307	25	as	as	IN
cord-277417-f71jwdzj	307	26	the	the	DT
cord-277417-f71jwdzj	307	27	outbreak	outbreak	NN
cord-277417-f71jwdzj	307	28	progressed	progress	VBD
cord-277417-f71jwdzj	307	29	,	,	,
cord-277417-f71jwdzj	307	30	such	such	JJ
cord-277417-f71jwdzj	307	31	that	that	IN
cord-277417-f71jwdzj	307	32	increased	increase	VBN
cord-277417-f71jwdzj	307	33	virulence	virulence	NN
cord-277417-f71jwdzj	307	34	is	be	VBZ
cord-277417-f71jwdzj	307	35	directly	directly	RB
cord-277417-f71jwdzj	307	36	selectively	selectively	RB
cord-277417-f71jwdzj	307	37	advantageous	advantageous	JJ
cord-277417-f71jwdzj	307	38	,	,	,
cord-277417-f71jwdzj	307	39	although	although	IN
cord-277417-f71jwdzj	307	40	this	this	DT
cord-277417-f71jwdzj	307	41	is	be	VBZ
cord-277417-f71jwdzj	307	42	confounded	confound	VBN
cord-277417-f71jwdzj	307	43	by	by	IN
cord-277417-f71jwdzj	307	44	epidemiological	epidemiological	JJ
cord-277417-f71jwdzj	307	45	factors	factor	NNS
cord-277417-f71jwdzj	307	46	.	.	.
cord-277417-f71jwdzj	308	1	Virulence	virulence	NN
cord-277417-f71jwdzj	308	2	evolution	evolution	NN
cord-277417-f71jwdzj	308	3	has	have	VBZ
cord-277417-f71jwdzj	308	4	been	be	VBN
cord-277417-f71jwdzj	308	5	one	one	CD
cord-277417-f71jwdzj	308	6	of	of	IN
cord-277417-f71jwdzj	308	7	the	the	DT
cord-277417-f71jwdzj	308	8	longest	long	RBS
cord-277417-f71jwdzj	308	9	-	-	HYPH
cord-277417-f71jwdzj	308	10	standing	stand	VBG
cord-277417-f71jwdzj	308	11	issues	issue	NNS
cord-277417-f71jwdzj	308	12	in	in	IN
cord-277417-f71jwdzj	308	13	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	308	14	biology	biology	NN
cord-277417-f71jwdzj	308	15	.	.	.
cord-277417-f71jwdzj	309	1	Although	although	IN
cord-277417-f71jwdzj	309	2	a	a	DT
cord-277417-f71jwdzj	309	3	strong	strong	JJ
cord-277417-f71jwdzj	309	4	body	body	NN
cord-277417-f71jwdzj	309	5	of	of	IN
cord-277417-f71jwdzj	309	6	theory	theory	NN
cord-277417-f71jwdzj	309	7	has	have	VBZ
cord-277417-f71jwdzj	309	8	been	be	VBN
cord-277417-f71jwdzj	309	9	developed	develop	VBN
cord-277417-f71jwdzj	309	10	,	,	,
cord-277417-f71jwdzj	309	11	there	there	EX
cord-277417-f71jwdzj	309	12	are	be	VBP
cord-277417-f71jwdzj	309	13	few	few	JJ
cord-277417-f71jwdzj	309	14	cases	case	NNS
cord-277417-f71jwdzj	309	15	in	in	IN
cord-277417-f71jwdzj	309	16	which	which	WDT
cord-277417-f71jwdzj	309	17	we	-PRON-	PRP
cord-277417-f71jwdzj	309	18	understand	understand	VBP
cord-277417-f71jwdzj	309	19	the	the	DT
cord-277417-f71jwdzj	309	20	forces	force	NNS
cord-277417-f71jwdzj	309	21	that	that	WDT
cord-277417-f71jwdzj	309	22	have	have	VBP
cord-277417-f71jwdzj	309	23	shaped	shape	VBN
cord-277417-f71jwdzj	309	24	particular	particular	JJ
cord-277417-f71jwdzj	309	25	instances	instance	NNS
cord-277417-f71jwdzj	309	26	of	of	IN
cord-277417-f71jwdzj	309	27	virulence	virulence	NN
cord-277417-f71jwdzj	309	28	evolution	evolution	NN
cord-277417-f71jwdzj	309	29	and	and	CC
cord-277417-f71jwdzj	309	30	even	even	RB
cord-277417-f71jwdzj	309	31	fewer	few	JJR
cord-277417-f71jwdzj	309	32	in	in	IN
cord-277417-f71jwdzj	309	33	which	which	WDT
cord-277417-f71jwdzj	309	34	we	-PRON-	PRP
cord-277417-f71jwdzj	309	35	have	have	VBP
cord-277417-f71jwdzj	309	36	successfully	successfully	RB
cord-277417-f71jwdzj	309	37	linked	link	VBN
cord-277417-f71jwdzj	309	38	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	309	39	theory	theory	NN
cord-277417-f71jwdzj	309	40	with	with	IN
cord-277417-f71jwdzj	309	41	individual	individual	JJ
cord-277417-f71jwdzj	309	42	genomic	genomic	JJ
cord-277417-f71jwdzj	309	43	changes	change	NNS
cord-277417-f71jwdzj	309	44	.	.	.
cord-277417-f71jwdzj	310	1	We	-PRON-	PRP
cord-277417-f71jwdzj	310	2	believe	believe	VBP
cord-277417-f71jwdzj	310	3	that	that	IN
cord-277417-f71jwdzj	310	4	a	a	DT
cord-277417-f71jwdzj	310	5	synthesis	synthesis	NN
cord-277417-f71jwdzj	310	6	of	of	IN
cord-277417-f71jwdzj	310	7	experimental	experimental	JJ
cord-277417-f71jwdzj	310	8	studies	study	NNS
cord-277417-f71jwdzj	310	9	of	of	IN
cord-277417-f71jwdzj	310	10	virulence	virulence	NN
cord-277417-f71jwdzj	310	11	determinants	determinant	NNS
cord-277417-f71jwdzj	310	12	and	and	CC
cord-277417-f71jwdzj	310	13	long	long	RB
cord-277417-f71jwdzj	310	14	-	-	HYPH
cord-277417-f71jwdzj	310	15	standing	stand	VBG
cord-277417-f71jwdzj	310	16	theory	theory	NN
cord-277417-f71jwdzj	310	17	of	of	IN
cord-277417-f71jwdzj	310	18	virulence	virulence	NN
cord-277417-f71jwdzj	310	19	evolution	evolution	NN
cord-277417-f71jwdzj	310	20	set	set	VBN
cord-277417-f71jwdzj	310	21	within	within	IN
cord-277417-f71jwdzj	310	22	a	a	DT
cord-277417-f71jwdzj	310	23	phylogenomic	phylogenomic	JJ
cord-277417-f71jwdzj	310	24	framework	framework	NN
cord-277417-f71jwdzj	310	25	will	will	MD
cord-277417-f71jwdzj	310	26	generate	generate	VB
cord-277417-f71jwdzj	310	27	a	a	DT
cord-277417-f71jwdzj	310	28	more	more	RBR
cord-277417-f71jwdzj	310	29	comprehensive	comprehensive	JJ
cord-277417-f71jwdzj	310	30	understanding	understanding	NN
cord-277417-f71jwdzj	310	31	of	of	IN
cord-277417-f71jwdzj	310	32	virulence	virulence	NN
cord-277417-f71jwdzj	310	33	evolution	evolution	NN
cord-277417-f71jwdzj	310	34	.	.	.
cord-277417-f71jwdzj	311	1	In	in	IN
cord-277417-f71jwdzj	311	2	particular	particular	JJ
cord-277417-f71jwdzj	311	3	,	,	,
cord-277417-f71jwdzj	311	4	not	not	RB
cord-277417-f71jwdzj	311	5	only	only	RB
cord-277417-f71jwdzj	311	6	does	do	VBZ
cord-277417-f71jwdzj	311	7	a	a	DT
cord-277417-f71jwdzj	311	8	phylogenomic	phylogenomic	JJ
cord-277417-f71jwdzj	311	9	approach	approach	NN
cord-277417-f71jwdzj	311	10	enable	enable	VB
cord-277417-f71jwdzj	311	11	potential	potential	JJ
cord-277417-f71jwdzj	311	12	virulence	virulence	NN
cord-277417-f71jwdzj	311	13	determinants	determinant	NNS
cord-277417-f71jwdzj	311	14	to	to	TO
cord-277417-f71jwdzj	311	15	be	be	VB
cord-277417-f71jwdzj	311	16	identified	identify	VBN
cord-277417-f71jwdzj	311	17	,	,	,
cord-277417-f71jwdzj	311	18	which	which	WDT
cord-277417-f71jwdzj	311	19	is	be	VBZ
cord-277417-f71jwdzj	311	20	being	be	VBG
cord-277417-f71jwdzj	311	21	increasingly	increasingly	RB
cord-277417-f71jwdzj	311	22	used	use	VBN
cord-277417-f71jwdzj	311	23	in	in	IN
cord-277417-f71jwdzj	311	24	the	the	DT
cord-277417-f71jwdzj	311	25	case	case	NN
cord-277417-f71jwdzj	311	26	of	of	IN
cord-277417-f71jwdzj	311	27	emerging	emerge	VBG
cord-277417-f71jwdzj	311	28	viruses	virus	NNS
cord-277417-f71jwdzj	311	29	,	,	,
cord-277417-f71jwdzj	311	30	but	but	CC
cord-277417-f71jwdzj	311	31	this	this	DT
cord-277417-f71jwdzj	311	32	analysis	analysis	NN
cord-277417-f71jwdzj	311	33	also	also	RB
cord-277417-f71jwdzj	311	34	sheds	shed	VBZ
cord-277417-f71jwdzj	311	35	light	light	NN
cord-277417-f71jwdzj	311	36	on	on	IN
cord-277417-f71jwdzj	311	37	the	the	DT
cord-277417-f71jwdzj	311	38	models	model	NNS
cord-277417-f71jwdzj	311	39	of	of	IN
cord-277417-f71jwdzj	311	40	virulence	virulence	NN
cord-277417-f71jwdzj	311	41	evolution	evolution	NN
cord-277417-f71jwdzj	311	42	that	that	WDT
cord-277417-f71jwdzj	311	43	have	have	VBP
cord-277417-f71jwdzj	311	44	occupied	occupy	VBN
cord-277417-f71jwdzj	311	45	theoreticians	theoretician	NNS
cord-277417-f71jwdzj	311	46	for	for	IN
cord-277417-f71jwdzj	311	47	decades	decade	NNS
cord-277417-f71jwdzj	311	48	.	.	.
cord-277417-f71jwdzj	312	1	Recent	recent	JJ
cord-277417-f71jwdzj	312	2	advances	advance	NNS
cord-277417-f71jwdzj	312	3	in	in	IN
cord-277417-f71jwdzj	312	4	real	real	JJ
cord-277417-f71jwdzj	312	5	-	-	HYPH
cord-277417-f71jwdzj	312	6	time	time	NN
cord-277417-f71jwdzj	312	7	genomics	genomic	NNS
cord-277417-f71jwdzj	312	8	during	during	IN
cord-277417-f71jwdzj	312	9	disease	disease	NN
cord-277417-f71jwdzj	312	10	outbreaks	outbreak	NNS
cord-277417-f71jwdzj	312	11	127	127	CD
cord-277417-f71jwdzj	312	12	,	,	,
cord-277417-f71jwdzj	312	13	128	128	CD
cord-277417-f71jwdzj	312	14	and	and	CC
cord-277417-f71jwdzj	312	15	the	the	DT
cord-277417-f71jwdzj	312	16	increased	increase	VBN
cord-277417-f71jwdzj	312	17	demand	demand	NN
cord-277417-f71jwdzj	312	18	for	for	IN
cord-277417-f71jwdzj	312	19	precision	precision	NN
cord-277417-f71jwdzj	312	20	in	in	IN
cord-277417-f71jwdzj	312	21	public	public	JJ
cord-277417-f71jwdzj	312	22	health	health	NN
cord-277417-f71jwdzj	312	23	interventions	intervention	NNS
cord-277417-f71jwdzj	312	24	may	may	MD
cord-277417-f71jwdzj	312	25	help	help	VB
cord-277417-f71jwdzj	312	26	in	in	IN
cord-277417-f71jwdzj	312	27	the	the	DT
cord-277417-f71jwdzj	312	28	development	development	NN
cord-277417-f71jwdzj	312	29	of	of	IN
cord-277417-f71jwdzj	312	30	a	a	DT
cord-277417-f71jwdzj	312	31	new	new	JJ
cord-277417-f71jwdzj	312	32	understanding	understanding	NN
cord-277417-f71jwdzj	312	33	of	of	IN
cord-277417-f71jwdzj	312	34	the	the	DT
cord-277417-f71jwdzj	312	35	evolution	evolution	NN
cord-277417-f71jwdzj	312	36	of	of	IN
cord-277417-f71jwdzj	312	37	pathogen	pathogen	NN
cord-277417-f71jwdzj	312	38	virulence	virulence	NN
cord-277417-f71jwdzj	312	39	.	.	.
cord-277417-f71jwdzj	313	1	We	-PRON-	PRP
cord-277417-f71jwdzj	313	2	contend	contend	VBP
cord-277417-f71jwdzj	313	3	that	that	IN
cord-277417-f71jwdzj	313	4	this	this	DT
cord-277417-f71jwdzj	313	5	can	can	MD
cord-277417-f71jwdzj	313	6	be	be	VB
cord-277417-f71jwdzj	313	7	achieved	achieve	VBN
cord-277417-f71jwdzj	313	8	within	within	IN
cord-277417-f71jwdzj	313	9	a	a	DT
cord-277417-f71jwdzj	313	10	phylogenomic	phylogenomic	JJ
cord-277417-f71jwdzj	313	11	framework	framework	NN
cord-277417-f71jwdzj	313	12	as	as	RB
cord-277417-f71jwdzj	313	13	long	long	RB
cord-277417-f71jwdzj	313	14	as	as	IN
cord-277417-f71jwdzj	313	15	relevant	relevant	JJ
cord-277417-f71jwdzj	313	16	data	datum	NNS
cord-277417-f71jwdzj	313	17	are	be	VBP
cord-277417-f71jwdzj	313	18	available	available	JJ
cord-277417-f71jwdzj	313	19	and	and	CC
cord-277417-f71jwdzj	313	20	strong	strong	JJ
cord-277417-f71jwdzj	313	21	links	link	NNS
cord-277417-f71jwdzj	313	22	are	be	VBP
cord-277417-f71jwdzj	313	23	made	make	VBN
cord-277417-f71jwdzj	313	24	between	between	IN
cord-277417-f71jwdzj	313	25	genomics	genomic	NNS
cord-277417-f71jwdzj	313	26	,	,	,
cord-277417-f71jwdzj	313	27	phylogenetics	phylogenetic	NNS
cord-277417-f71jwdzj	313	28	,	,	,
cord-277417-f71jwdzj	313	29	epidemiology	epidemiology	NN
cord-277417-f71jwdzj	313	30	,	,	,
cord-277417-f71jwdzj	313	31	and	and	CC
cord-277417-f71jwdzj	313	32	experimental	experimental	JJ
cord-277417-f71jwdzj	313	33	studies	study	NNS
cord-277417-f71jwdzj	313	34	of	of	IN
cord-277417-f71jwdzj	313	35	virus	virus	NN
cord-277417-f71jwdzj	313	36	virulence	virulence	NN
cord-277417-f71jwdzj	313	37	and	and	CC
cord-277417-f71jwdzj	313	38	fitness	fitness	NN
cord-277417-f71jwdzj	313	39	.	.	.
cord-277417-f71jwdzj	314	1	Therefore	therefore	RB
cord-277417-f71jwdzj	314	2	,	,	,
cord-277417-f71jwdzj	314	3	it	-PRON-	PRP
cord-277417-f71jwdzj	314	4	is	be	VBZ
cord-277417-f71jwdzj	314	5	critically	critically	RB
cord-277417-f71jwdzj	314	6	important	important	JJ
cord-277417-f71jwdzj	314	7	to	to	TO
cord-277417-f71jwdzj	314	8	collect	collect	VB
cord-277417-f71jwdzj	314	9	clinical	clinical	JJ
cord-277417-f71jwdzj	314	10	(	(	-LRB-
cord-277417-f71jwdzj	314	11	that	that	RB
cord-277417-f71jwdzj	314	12	is	is	RB
cord-277417-f71jwdzj	314	13	,	,	,
cord-277417-f71jwdzj	314	14	disease	disease	NN
cord-277417-f71jwdzj	314	15	symptoms	symptom	NNS
cord-277417-f71jwdzj	314	16	and	and	CC
cord-277417-f71jwdzj	314	17	severity	severity	NN
cord-277417-f71jwdzj	314	18	)	)	-RRB-
cord-277417-f71jwdzj	314	19	and	and	CC
cord-277417-f71jwdzj	314	20	epidemiological	epidemiological	JJ
cord-277417-f71jwdzj	314	21	(	(	-LRB-
cord-277417-f71jwdzj	315	1	that	that	DT
cord-277417-f71jwdzj	315	2	is	is	RB
cord-277417-f71jwdzj	315	3	,	,	,
cord-277417-f71jwdzj	315	4	time	time	NN
cord-277417-f71jwdzj	315	5	and	and	CC
cord-277417-f71jwdzj	315	6	place	place	NN
cord-277417-f71jwdzj	315	7	of	of	IN
cord-277417-f71jwdzj	315	8	sampling	sampling	NN
cord-277417-f71jwdzj	315	9	)	)	-RRB-
cord-277417-f71jwdzj	315	10	metadata	metadata	NN
cord-277417-f71jwdzj	315	11	concurrently	concurrently	RB
cord-277417-f71jwdzj	315	12	with	with	IN
cord-277417-f71jwdzj	315	13	the	the	DT
cord-277417-f71jwdzj	315	14	sequencing	sequencing	NN
cord-277417-f71jwdzj	315	15	of	of	IN
cord-277417-f71jwdzj	315	16	virus	virus	NN
cord-277417-f71jwdzj	315	17	genomes	genome	NNS
cord-277417-f71jwdzj	315	18	and	and	CC
cord-277417-f71jwdzj	315	19	to	to	TO
cord-277417-f71jwdzj	315	20	sample	sample	VB
cord-277417-f71jwdzj	315	21	across	across	IN
cord-277417-f71jwdzj	315	22	a	a	DT
cord-277417-f71jwdzj	315	23	range	range	NN
cord-277417-f71jwdzj	315	24	of	of	IN
cord-277417-f71jwdzj	315	25	clinical	clinical	JJ
cord-277417-f71jwdzj	315	26	syndromes	syndrome	NNS
cord-277417-f71jwdzj	315	27	,	,	,
cord-277417-f71jwdzj	315	28	not	not	RB
cord-277417-f71jwdzj	315	29	just	just	RB
cord-277417-f71jwdzj	315	30	those	those	DT
cord-277417-f71jwdzj	315	31	associated	associate	VBN
cord-277417-f71jwdzj	315	32	with	with	IN
cord-277417-f71jwdzj	315	33	severe	severe	JJ
cord-277417-f71jwdzj	315	34	disease	disease	NN
cord-277417-f71jwdzj	315	35	.	.	.
cord-277417-f71jwdzj	316	1	We	-PRON-	PRP
cord-277417-f71jwdzj	316	2	also	also	RB
cord-277417-f71jwdzj	316	3	stress	stress	VBP
cord-277417-f71jwdzj	316	4	the	the	DT
cord-277417-f71jwdzj	316	5	value	value	NN
cord-277417-f71jwdzj	316	6	of	of	IN
cord-277417-f71jwdzj	316	7	gathering	gather	VBG
cord-277417-f71jwdzj	316	8	concurrent	concurrent	JJ
cord-277417-f71jwdzj	316	9	and	and	CC
cord-277417-f71jwdzj	316	10	historical	historical	JJ
cord-277417-f71jwdzj	316	11	data	datum	NNS
cord-277417-f71jwdzj	316	12	from	from	IN
cord-277417-f71jwdzj	316	13	likely	likely	JJ
cord-277417-f71jwdzj	316	14	reservoir	reservoir	NN
cord-277417-f71jwdzj	316	15	species	specie	NNS
cord-277417-f71jwdzj	316	16	as	as	IN
cord-277417-f71jwdzj	316	17	these	these	DT
cord-277417-f71jwdzj	316	18	will	will	MD
cord-277417-f71jwdzj	316	19	provide	provide	VB
cord-277417-f71jwdzj	316	20	a	a	DT
cord-277417-f71jwdzj	316	21	more	more	RBR
cord-277417-f71jwdzj	316	22	complete	complete	JJ
cord-277417-f71jwdzj	316	23	insight	insight	NN
cord-277417-f71jwdzj	316	24	into	into	IN
cord-277417-f71jwdzj	316	25	virulence	virulence	NN
cord-277417-f71jwdzj	316	26	evolution	evolution	NN
cord-277417-f71jwdzj	316	27	and	and	CC
cord-277417-f71jwdzj	316	28	determining	determine	VBG
cord-277417-f71jwdzj	316	29	the	the	DT
cord-277417-f71jwdzj	316	30	full	full	JJ
cord-277417-f71jwdzj	316	31	range	range	NN
cord-277417-f71jwdzj	316	32	of	of	IN
cord-277417-f71jwdzj	316	33	microorganisms	microorganism	NNS
cord-277417-f71jwdzj	316	34	that	that	WDT
cord-277417-f71jwdzj	316	35	infect	infect	VBP
cord-277417-f71jwdzj	316	36	a	a	DT
cord-277417-f71jwdzj	316	37	particular	particular	JJ
cord-277417-f71jwdzj	316	38	species	specie	NNS
cord-277417-f71jwdzj	316	39	,	,	,
cord-277417-f71jwdzj	316	40	as	as	RB
cord-277417-f71jwdzj	316	41	well	well	RB
cord-277417-f71jwdzj	316	42	as	as	IN
cord-277417-f71jwdzj	316	43	their	-PRON-	PRP$
cord-277417-f71jwdzj	316	44	interactions	interaction	NNS
cord-277417-f71jwdzj	316	45	,	,	,
cord-277417-f71jwdzj	316	46	as	as	IN
cord-277417-f71jwdzj	316	47	assigning	assign	VBG
cord-277417-f71jwdzj	316	48	disease	disease	NN
cord-277417-f71jwdzj	316	49	syndromes	syndrome	NNS
cord-277417-f71jwdzj	316	50	to	to	IN
cord-277417-f71jwdzj	316	51	individual	individual	JJ
cord-277417-f71jwdzj	316	52	pathogens	pathogen	NNS
cord-277417-f71jwdzj	316	53	may	may	MD
cord-277417-f71jwdzj	316	54	often	often	RB
cord-277417-f71jwdzj	316	55	be	be	VB
cord-277417-f71jwdzj	316	56	difficult	difficult	JJ
cord-277417-f71jwdzj	316	57	.	.	.
cord-277417-f71jwdzj	317	1	Thankfully	thankfully	RB
cord-277417-f71jwdzj	317	2	,	,	,
cord-277417-f71jwdzj	317	3	advances	advance	VBZ
cord-277417-f71jwdzj	317	4	in	in	IN
cord-277417-f71jwdzj	317	5	metagenomics	metagenomic	NNS
cord-277417-f71jwdzj	317	6	now	now	RB
cord-277417-f71jwdzj	317	7	make	make	VBP
cord-277417-f71jwdzj	317	8	the	the	DT
cord-277417-f71jwdzj	317	9	latter	latter	JJ
cord-277417-f71jwdzj	317	10	task	task	NN
cord-277417-f71jwdzj	317	11	feasible	feasible	JJ
cord-277417-f71jwdzj	317	12	6	6	CD
cord-277417-f71jwdzj	317	13	,	,	,
cord-277417-f71jwdzj	317	14	7	7	CD
cord-277417-f71jwdzj	317	15	,	,	,
cord-277417-f71jwdzj	317	16	129	129	CD
cord-277417-f71jwdzj	317	17	.	.	.
cord-277417-f71jwdzj	318	1	Similarly	similarly	RB
cord-277417-f71jwdzj	318	2	,	,	,
cord-277417-f71jwdzj	318	3	there	there	EX
cord-277417-f71jwdzj	318	4	is	be	VBZ
cord-277417-f71jwdzj	318	5	a	a	DT
cord-277417-f71jwdzj	318	6	marked	marked	JJ
cord-277417-f71jwdzj	318	7	lack	lack	NN
cord-277417-f71jwdzj	318	8	of	of	IN
cord-277417-f71jwdzj	318	9	good	good	JJ
cord-277417-f71jwdzj	318	10	virulence	virulence	NN
cord-277417-f71jwdzj	318	11	grading	grading	NN
cord-277417-f71jwdzj	318	12	schemes	scheme	NNS
cord-277417-f71jwdzj	318	13	among	among	IN
cord-277417-f71jwdzj	318	14	viral	viral	JJ
cord-277417-f71jwdzj	318	15	infections	infection	NNS
cord-277417-f71jwdzj	318	16	.	.	.
cord-277417-f71jwdzj	319	1	Although	although	IN
cord-277417-f71jwdzj	319	2	such	such	JJ
cord-277417-f71jwdzj	319	3	schemes	scheme	NNS
cord-277417-f71jwdzj	319	4	can	can	MD
cord-277417-f71jwdzj	319	5	sometimes	sometimes	RB
cord-277417-f71jwdzj	319	6	be	be	VB
cord-277417-f71jwdzj	319	7	simplistic	simplistic	JJ
cord-277417-f71jwdzj	319	8	,	,	,
cord-277417-f71jwdzj	319	9	assuming	assume	VBG
cord-277417-f71jwdzj	319	10	discrete	discrete	JJ
cord-277417-f71jwdzj	319	11	virulence	virulence	NN
cord-277417-f71jwdzj	319	12	categories	category	NNS
cord-277417-f71jwdzj	319	13	that	that	WDT
cord-277417-f71jwdzj	319	14	may	may	MD
cord-277417-f71jwdzj	319	15	not	not	RB
cord-277417-f71jwdzj	319	16	exist	exist	VB
cord-277417-f71jwdzj	319	17	in	in	IN
cord-277417-f71jwdzj	319	18	nature	nature	NN
cord-277417-f71jwdzj	319	19	and	and	CC
cord-277417-f71jwdzj	319	20	incorporating	incorporate	VBG
cord-277417-f71jwdzj	319	21	degrees	degree	NNS
cord-277417-f71jwdzj	319	22	of	of	IN
cord-277417-f71jwdzj	319	23	subjectivity	subjectivity	NN
cord-277417-f71jwdzj	319	24	,	,	,
cord-277417-f71jwdzj	319	25	the	the	DT
cord-277417-f71jwdzj	319	26	case	case	NN
cord-277417-f71jwdzj	319	27	of	of	IN
cord-277417-f71jwdzj	319	28	MYXV	MYXV	NNP
cord-277417-f71jwdzj	319	29	shows	show	VBZ
cord-277417-f71jwdzj	319	30	that	that	IN
cord-277417-f71jwdzj	319	31	they	-PRON-	PRP
cord-277417-f71jwdzj	319	32	are	be	VBP
cord-277417-f71jwdzj	319	33	key	key	JJ
cord-277417-f71jwdzj	319	34	to	to	IN
cord-277417-f71jwdzj	319	35	considering	consider	VBG
cord-277417-f71jwdzj	319	36	the	the	DT
cord-277417-f71jwdzj	319	37	relationship	relationship	NN
cord-277417-f71jwdzj	319	38	between	between	IN
cord-277417-f71jwdzj	319	39	genotype	genotype	NN
cord-277417-f71jwdzj	319	40	and	and	CC
cord-277417-f71jwdzj	319	41	phenotype	phenotype	NN
cord-277417-f71jwdzj	319	42	that	that	WDT
cord-277417-f71jwdzj	319	43	is	be	VBZ
cord-277417-f71jwdzj	319	44	essential	essential	JJ
cord-277417-f71jwdzj	319	45	to	to	IN
cord-277417-f71jwdzj	319	46	understanding	understanding	JJ
cord-277417-f71jwdzj	319	47	virulence	virulence	NN
cord-277417-f71jwdzj	319	48	evolution	evolution	NN
cord-277417-f71jwdzj	319	49	.	.	.
cord-277417-f71jwdzj	320	1	Finally	finally	RB
cord-277417-f71jwdzj	320	2	,	,	,
cord-277417-f71jwdzj	320	3	it	-PRON-	PRP
cord-277417-f71jwdzj	320	4	is	be	VBZ
cord-277417-f71jwdzj	320	5	possible	possible	JJ
cord-277417-f71jwdzj	320	6	that	that	IN
cord-277417-f71jwdzj	320	7	an	an	DT
cord-277417-f71jwdzj	320	8	increased	increase	VBN
cord-277417-f71jwdzj	320	9	understanding	understanding	NN
cord-277417-f71jwdzj	320	10	of	of	IN
cord-277417-f71jwdzj	320	11	virulence	virulence	NN
cord-277417-f71jwdzj	320	12	evolution	evolution	NN
cord-277417-f71jwdzj	320	13	drawn	draw	VBN
cord-277417-f71jwdzj	320	14	from	from	IN
cord-277417-f71jwdzj	320	15	a	a	DT
cord-277417-f71jwdzj	320	16	phylogenomic	phylogenomic	JJ
cord-277417-f71jwdzj	320	17	approach	approach	NN
cord-277417-f71jwdzj	320	18	may	may	MD
cord-277417-f71jwdzj	320	19	contribute	contribute	VB
cord-277417-f71jwdzj	320	20	to	to	IN
cord-277417-f71jwdzj	320	21	new	new	JJ
cord-277417-f71jwdzj	320	22	strategies	strategy	NNS
cord-277417-f71jwdzj	320	23	for	for	IN
cord-277417-f71jwdzj	320	24	pathogen	pathogen	NN
cord-277417-f71jwdzj	320	25	control	control	NN
cord-277417-f71jwdzj	320	26	and	and	CC
cord-277417-f71jwdzj	320	27	eradication	eradication	NN
cord-277417-f71jwdzj	320	28	,	,	,
cord-277417-f71jwdzj	320	29	and	and	CC
cord-277417-f71jwdzj	320	30	there	there	EX
cord-277417-f71jwdzj	320	31	is	be	VBZ
cord-277417-f71jwdzj	320	32	a	a	DT
cord-277417-f71jwdzj	320	33	clear	clear	JJ
cord-277417-f71jwdzj	320	34	potential	potential	NN
cord-277417-f71jwdzj	320	35	for	for	IN
cord-277417-f71jwdzj	320	36	this	this	DT
cord-277417-f71jwdzj	320	37	framework	framework	NN
cord-277417-f71jwdzj	320	38	to	to	TO
cord-277417-f71jwdzj	320	39	inform	inform	VB
cord-277417-f71jwdzj	320	40	and	and	CC
cord-277417-f71jwdzj	320	41	improve	improve	VB
cord-277417-f71jwdzj	320	42	the	the	DT
cord-277417-f71jwdzj	320	43	fields	field	NNS
cord-277417-f71jwdzj	320	44	of	of	IN
cord-277417-f71jwdzj	320	45	disease	disease	NN
cord-277417-f71jwdzj	320	46	management	management	NN
cord-277417-f71jwdzj	320	47	and	and	CC
cord-277417-f71jwdzj	320	48	the	the	DT
cord-277417-f71jwdzj	320	49	biological	biological	JJ
cord-277417-f71jwdzj	320	50	control	control	NN
cord-277417-f71jwdzj	320	51	of	of	IN
cord-277417-f71jwdzj	320	52	invasive	invasive	JJ
cord-277417-f71jwdzj	320	53	pests	pest	NNS
cord-277417-f71jwdzj	320	54	.	.	.
cord-277417-f71jwdzj	321	1	Although	although	IN
cord-277417-f71jwdzj	321	2	predicting	predict	VBG
cord-277417-f71jwdzj	321	3	where	where	WRB
cord-277417-f71jwdzj	321	4	and	and	CC
cord-277417-f71jwdzj	321	5	when	when	WRB
cord-277417-f71jwdzj	321	6	a	a	DT
cord-277417-f71jwdzj	321	7	new	new	JJ
cord-277417-f71jwdzj	321	8	disease	disease	NN
cord-277417-f71jwdzj	321	9	might	may	MD
cord-277417-f71jwdzj	321	10	emerge	emerge	VB
cord-277417-f71jwdzj	321	11	is	be	VBZ
cord-277417-f71jwdzj	321	12	clearly	clearly	RB
cord-277417-f71jwdzj	321	13	unfeasible	unfeasible	JJ
cord-277417-f71jwdzj	321	14	because	because	IN
cord-277417-f71jwdzj	321	15	of	of	IN
cord-277417-f71jwdzj	321	16	the	the	DT
cord-277417-f71jwdzj	321	17	immense	immense	JJ
cord-277417-f71jwdzj	321	18	complexities	complexity	NNS
cord-277417-f71jwdzj	321	19	involved	involve	VBD
cord-277417-f71jwdzj	321	20	54	54	CD
cord-277417-f71jwdzj	321	21	,	,	,
cord-277417-f71jwdzj	321	22	130	130	CD
cord-277417-f71jwdzj	321	23	,	,	,
cord-277417-f71jwdzj	321	24	predicting	predict	VBG
cord-277417-f71jwdzj	321	25	the	the	DT
cord-277417-f71jwdzj	321	26	overall	overall	JJ
cord-277417-f71jwdzj	321	27	trajectory	trajectory	NN
cord-277417-f71jwdzj	321	28	of	of	IN
cord-277417-f71jwdzj	321	29	the	the	DT
cord-277417-f71jwdzj	321	30	virulence	virulence	NN
cord-277417-f71jwdzj	321	31	evolution	evolution	NN
cord-277417-f71jwdzj	321	32	of	of	IN
cord-277417-f71jwdzj	321	33	a	a	DT
cord-277417-f71jwdzj	321	34	virus	virus	NN
cord-277417-f71jwdzj	321	35	in	in	IN
cord-277417-f71jwdzj	321	36	a	a	DT
cord-277417-f71jwdzj	321	37	novel	novel	JJ
cord-277417-f71jwdzj	321	38	host	host	NN
cord-277417-f71jwdzj	321	39	may	may	MD
cord-277417-f71jwdzj	321	40	be	be	VB
cord-277417-f71jwdzj	321	41	more	more	RBR
cord-277417-f71jwdzj	321	42	achievable	achievable	JJ
cord-277417-f71jwdzj	321	43	.	.	.
cord-277417-f71jwdzj	322	1	Once	once	RB
cord-277417-f71jwdzj	322	2	again	again	RB
cord-277417-f71jwdzj	322	3	,	,	,
cord-277417-f71jwdzj	322	4	biocontrol	biocontrol	NN
cord-277417-f71jwdzj	322	5	presents	present	VBZ
cord-277417-f71jwdzj	322	6	a	a	DT
cord-277417-f71jwdzj	322	7	compelling	compelling	JJ
cord-277417-f71jwdzj	322	8	example	example	NN
cord-277417-f71jwdzj	322	9	.	.	.
cord-277417-f71jwdzj	323	1	Although	although	IN
cord-277417-f71jwdzj	323	2	controversial	controversial	JJ
cord-277417-f71jwdzj	323	3	[	[	-LRB-
cord-277417-f71jwdzj	323	4	131	131	CD
cord-277417-f71jwdzj	323	5	]	]	-RRB-
cord-277417-f71jwdzj	324	1	[	[	-LRB-
cord-277417-f71jwdzj	324	2	132	132	CD
cord-277417-f71jwdzj	324	3	]	]	-RRB-
cord-277417-f71jwdzj	324	4	[	[	-LRB-
cord-277417-f71jwdzj	324	5	133	133	CD
cord-277417-f71jwdzj	324	6	]	]	-RRB-
cord-277417-f71jwdzj	324	7	,	,	,
cord-277417-f71jwdzj	324	8	the	the	DT
cord-277417-f71jwdzj	324	9	proposed	propose	VBN
cord-277417-f71jwdzj	324	10	release	release	NN
cord-277417-f71jwdzj	324	11	of	of	IN
cord-277417-f71jwdzj	324	12	cyprinid	cyprinid	JJ
cord-277417-f71jwdzj	324	13	herpesvirus	herpesvirus	NNP
cord-277417-f71jwdzj	324	14	3	3	CD
cord-277417-f71jwdzj	324	15	(	(	-LRB-
cord-277417-f71jwdzj	324	16	CyHV-3	CyHV-3	NFP
cord-277417-f71jwdzj	324	17	)	)	-RRB-
cord-277417-f71jwdzj	324	18	as	as	IN
cord-277417-f71jwdzj	324	19	a	a	DT
cord-277417-f71jwdzj	324	20	biological	biological	JJ
cord-277417-f71jwdzj	324	21	control	control	NN
cord-277417-f71jwdzj	324	22	against	against	IN
cord-277417-f71jwdzj	324	23	invasive	invasive	JJ
cord-277417-f71jwdzj	324	24	common	common	JJ
cord-277417-f71jwdzj	324	25	carp	carp	NN
cord-277417-f71jwdzj	325	1	(	(	-LRB-
cord-277417-f71jwdzj	325	2	Cyprinus	Cyprinus	NNP
cord-277417-f71jwdzj	325	3	carpio	carpio	NNP
cord-277417-f71jwdzj	325	4	L.	L.	NNP
cord-277417-f71jwdzj	325	5	)	)	-RRB-
cord-277417-f71jwdzj	325	6	in	in	IN
cord-277417-f71jwdzj	325	7	Australia	Australia	NNP
cord-277417-f71jwdzj	325	8	may	may	MD
cord-277417-f71jwdzj	325	9	present	present	VB
cord-277417-f71jwdzj	325	10	a	a	DT
cord-277417-f71jwdzj	325	11	unique	unique	JJ
cord-277417-f71jwdzj	325	12	opportunity	opportunity	NN
cord-277417-f71jwdzj	325	13	to	to	TO
cord-277417-f71jwdzj	325	14	follow	follow	VB
cord-277417-f71jwdzj	325	15	,	,	,
cord-277417-f71jwdzj	325	16	in	in	IN
cord-277417-f71jwdzj	325	17	real	real	JJ
cord-277417-f71jwdzj	325	18	time	time	NN
cord-277417-f71jwdzj	325	19	,	,	,
cord-277417-f71jwdzj	325	20	the	the	DT
cord-277417-f71jwdzj	325	21	co	co	NN
cord-277417-f71jwdzj	325	22	-	-	NN
cord-277417-f71jwdzj	325	23	evolution	evolution	NN
cord-277417-f71jwdzj	325	24	between	between	IN
cord-277417-f71jwdzj	325	25	host	host	NN
cord-277417-f71jwdzj	325	26	and	and	CC
cord-277417-f71jwdzj	325	27	virus	virus	NN
cord-277417-f71jwdzj	325	28	at	at	IN
cord-277417-f71jwdzj	325	29	both	both	CC
cord-277417-f71jwdzj	325	30	the	the	DT
cord-277417-f71jwdzj	325	31	genotypic	genotypic	JJ
cord-277417-f71jwdzj	325	32	and	and	CC
cord-277417-f71jwdzj	325	33	phenotypic	phenotypic	JJ
cord-277417-f71jwdzj	325	34	scales	scale	NNS
cord-277417-f71jwdzj	325	35	.	.	.
cord-277417-f71jwdzj	326	1	Both	both	DT
cord-277417-f71jwdzj	326	2	theory	theory	NN
cord-277417-f71jwdzj	326	3	and	and	CC
cord-277417-f71jwdzj	326	4	virus	virus	NN
cord-277417-f71jwdzj	326	5	natural	natural	JJ
cord-277417-f71jwdzj	326	6	history	history	NN
cord-277417-f71jwdzj	326	7	predict	predict	VBP
cord-277417-f71jwdzj	326	8	that	that	IN
cord-277417-f71jwdzj	326	9	CyHV-3	CyHV-3	NNP
cord-277417-f71jwdzj	326	10	virulence	virulence	NN
cord-277417-f71jwdzj	326	11	will	will	MD
cord-277417-f71jwdzj	326	12	decline	decline	VB
cord-277417-f71jwdzj	326	13	with	with	IN
cord-277417-f71jwdzj	326	14	time	time	NN
cord-277417-f71jwdzj	326	15	134	134	CD
cord-277417-f71jwdzj	326	16	,	,	,
cord-277417-f71jwdzj	326	17	and	and	CC
cord-277417-f71jwdzj	326	18	it	-PRON-	PRP
cord-277417-f71jwdzj	326	19	will	will	MD
cord-277417-f71jwdzj	326	20	be	be	VB
cord-277417-f71jwdzj	326	21	interesting	interesting	JJ
cord-277417-f71jwdzj	326	22	and	and	CC
cord-277417-f71jwdzj	326	23	informative	informative	JJ
cord-277417-f71jwdzj	326	24	to	to	TO
cord-277417-f71jwdzj	326	25	see	see	VB
cord-277417-f71jwdzj	326	26	how	how	WRB
cord-277417-f71jwdzj	326	27	any	any	DT
cord-277417-f71jwdzj	326	28	such	such	JJ
cord-277417-f71jwdzj	326	29	virulence	virulence	NN
cord-277417-f71jwdzj	326	30	evolution	evolution	NN
cord-277417-f71jwdzj	326	31	is	be	VBZ
cord-277417-f71jwdzj	326	32	manifest	manifest	JJ
cord-277417-f71jwdzj	326	33	in	in	IN
cord-277417-f71jwdzj	326	34	phylogenomic	phylogenomic	NNP
cord-277417-f71jwdzj	326	35	data	datum	NNS
cord-277417-f71jwdzj	326	36	.	.	.
cord-277417-f71jwdzj	327	1	This	this	DT
cord-277417-f71jwdzj	327	2	review	review	NN
cord-277417-f71jwdzj	327	3	provides	provide	VBZ
cord-277417-f71jwdzj	327	4	insight	insight	NN
cord-277417-f71jwdzj	327	5	into	into	IN
cord-277417-f71jwdzj	327	6	how	how	WRB
cord-277417-f71jwdzj	327	7	virulence	virulence	NN
cord-277417-f71jwdzj	327	8	theory	theory	NN
cord-277417-f71jwdzj	327	9	might	may	MD
cord-277417-f71jwdzj	327	10	be	be	VB
cord-277417-f71jwdzj	327	11	united	unite	VBN
cord-277417-f71jwdzj	327	12	with	with	IN
cord-277417-f71jwdzj	327	13	empirical	empirical	JJ
cord-277417-f71jwdzj	327	14	data	datum	NNS
cord-277417-f71jwdzj	327	15	and	and	CC
cord-277417-f71jwdzj	327	16	what	what	WP
cord-277417-f71jwdzj	327	17	is	be	VBZ
cord-277417-f71jwdzj	327	18	needed	need	VBN
cord-277417-f71jwdzj	327	19	to	to	TO
cord-277417-f71jwdzj	327	20	better	better	RB
cord-277417-f71jwdzj	327	21	understand	understand	VB
cord-277417-f71jwdzj	327	22	the	the	DT
cord-277417-f71jwdzj	327	23	relationship	relationship	NN
cord-277417-f71jwdzj	327	24	between	between	IN
cord-277417-f71jwdzj	327	25	virulence	virulence	NN
cord-277417-f71jwdzj	327	26	and	and	CC
cord-277417-f71jwdzj	327	27	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	327	28	Elevated	elevated	JJ
cord-277417-f71jwdzj	327	29	virulence	virulence	NN
cord-277417-f71jwdzj	327	30	of	of	IN
cord-277417-f71jwdzj	327	31	an	an	DT
cord-277417-f71jwdzj	327	32	emerging	emerge	VBG
cord-277417-f71jwdzj	327	33	viral	viral	JJ
cord-277417-f71jwdzj	327	34	genotype	genotype	NN
cord-277417-f71jwdzj	327	35	as	as	IN
cord-277417-f71jwdzj	327	36	a	a	DT
cord-277417-f71jwdzj	327	37	driver	driver	NN
cord-277417-f71jwdzj	327	38	of	of	IN
cord-277417-f71jwdzj	327	39	honeybee	honeybee	NN
cord-277417-f71jwdzj	327	40	loss	loss	NN
cord-277417-f71jwdzj	327	41	Microbial	microbial	JJ
cord-277417-f71jwdzj	327	42	genome	genome	NN
cord-277417-f71jwdzj	327	43	-	-	HYPH
cord-277417-f71jwdzj	327	44	wide	wide	JJ
cord-277417-f71jwdzj	327	45	association	association	NN
cord-277417-f71jwdzj	327	46	studies	study	NNS
cord-277417-f71jwdzj	327	47	:	:	:
cord-277417-f71jwdzj	327	48	lessons	lesson	NNS
cord-277417-f71jwdzj	327	49	from	from	IN
cord-277417-f71jwdzj	327	50	human	human	JJ
cord-277417-f71jwdzj	327	51	GWAS	GWAS	NNP
cord-277417-f71jwdzj	327	52	Genome	Genome	NNP
cord-277417-f71jwdzj	327	53	-	-	HYPH
cord-277417-f71jwdzj	327	54	to	to	IN
cord-277417-f71jwdzj	327	55	-	-	HYPH
cord-277417-f71jwdzj	327	56	genome	genome	NN
cord-277417-f71jwdzj	327	57	analysis	analysis	NN
cord-277417-f71jwdzj	327	58	highlights	highlight	VBZ
cord-277417-f71jwdzj	327	59	the	the	DT
cord-277417-f71jwdzj	327	60	effect	effect	NN
cord-277417-f71jwdzj	327	61	of	of	IN
cord-277417-f71jwdzj	327	62	the	the	DT
cord-277417-f71jwdzj	327	63	human	human	JJ
cord-277417-f71jwdzj	327	64	innate	innate	JJ
cord-277417-f71jwdzj	327	65	and	and	CC
cord-277417-f71jwdzj	327	66	adaptive	adaptive	JJ
cord-277417-f71jwdzj	327	67	immune	immune	JJ
cord-277417-f71jwdzj	327	68	systems	system	NNS
cord-277417-f71jwdzj	327	69	on	on	IN
cord-277417-f71jwdzj	327	70	the	the	DT
cord-277417-f71jwdzj	327	71	hepatitis	hepatitis	NN
cord-277417-f71jwdzj	327	72	C	C	NNP
cord-277417-f71jwdzj	327	73	virus	virus	NN
cord-277417-f71jwdzj	328	1	Unbiased	unbiased	JJ
cord-277417-f71jwdzj	328	2	parallel	parallel	JJ
cord-277417-f71jwdzj	328	3	detection	detection	NN
cord-277417-f71jwdzj	328	4	of	of	IN
cord-277417-f71jwdzj	328	5	viral	viral	JJ
cord-277417-f71jwdzj	328	6	pathogens	pathogen	NNS
cord-277417-f71jwdzj	328	7	in	in	IN
cord-277417-f71jwdzj	328	8	clinical	clinical	JJ
cord-277417-f71jwdzj	328	9	samples	sample	NNS
cord-277417-f71jwdzj	328	10	by	by	IN
cord-277417-f71jwdzj	328	11	use	use	NN
cord-277417-f71jwdzj	328	12	of	of	IN
cord-277417-f71jwdzj	328	13	a	a	DT
cord-277417-f71jwdzj	328	14	metagenomic	metagenomic	JJ
cord-277417-f71jwdzj	328	15	approach	approach	NN
cord-277417-f71jwdzj	328	16	Redefining	redefine	VBG
cord-277417-f71jwdzj	328	17	the	the	DT
cord-277417-f71jwdzj	328	18	invertebrate	invertebrate	NN
cord-277417-f71jwdzj	328	19	virosphere	virosphere	NN
cord-277417-f71jwdzj	329	1	The	the	DT
cord-277417-f71jwdzj	329	2	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	329	3	history	history	NN
cord-277417-f71jwdzj	329	4	of	of	IN
cord-277417-f71jwdzj	329	5	vertebrate	vertebrate	JJ
cord-277417-f71jwdzj	329	6	RNA	RNA	NNP
cord-277417-f71jwdzj	329	7	viruses	virus	NNS
cord-277417-f71jwdzj	330	1	This	this	DT
cord-277417-f71jwdzj	330	2	study	study	NN
cord-277417-f71jwdzj	330	3	is	be	VBZ
cord-277417-f71jwdzj	330	4	a	a	DT
cord-277417-f71jwdzj	330	5	powerful	powerful	JJ
cord-277417-f71jwdzj	330	6	example	example	NN
cord-277417-f71jwdzj	330	7	of	of	IN
cord-277417-f71jwdzj	330	8	the	the	DT
cord-277417-f71jwdzj	330	9	analytical	analytical	JJ
cord-277417-f71jwdzj	330	10	approach	approach	NN
cord-277417-f71jwdzj	330	11	outlined	outline	VBN
cord-277417-f71jwdzj	330	12	here	here	RB
cord-277417-f71jwdzj	330	13	.	.	.
cord-277417-f71jwdzj	331	1	The	the	DT
cord-277417-f71jwdzj	331	2	authors	author	NNS
cord-277417-f71jwdzj	331	3	use	use	VBP
cord-277417-f71jwdzj	331	4	phylogenetics	phylogenetic	NNS
cord-277417-f71jwdzj	331	5	and	and	CC
cord-277417-f71jwdzj	331	6	experimental	experimental	JJ
cord-277417-f71jwdzj	331	7	study	study	NN
cord-277417-f71jwdzj	331	8	to	to	TO
cord-277417-f71jwdzj	331	9	describe	describe	VB
cord-277417-f71jwdzj	331	10	the	the	DT
cord-277417-f71jwdzj	331	11	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	331	12	pathways	pathway	NNS
cord-277417-f71jwdzj	331	13	by	by	IN
cord-277417-f71jwdzj	331	14	which	which	WDT
cord-277417-f71jwdzj	331	15	OPV	OPV	NNP
cord-277417-f71jwdzj	331	16	strains	strain	NNS
cord-277417-f71jwdzj	331	17	become	become	VBP
cord-277417-f71jwdzj	331	18	pathogenic	pathogenic	JJ
cord-277417-f71jwdzj	331	19	and	and	CC
cord-277417-f71jwdzj	331	20	propose	propose	VB
cord-277417-f71jwdzj	331	21	a	a	DT
cord-277417-f71jwdzj	331	22	framework	framework	NN
cord-277417-f71jwdzj	331	23	for	for	IN
cord-277417-f71jwdzj	331	24	vaccine	vaccine	NN
cord-277417-f71jwdzj	331	25	design	design	NN
cord-277417-f71jwdzj	332	1	Did	do	VBD
cord-277417-f71jwdzj	332	2	Zika	Zika	NNP
cord-277417-f71jwdzj	332	3	virus	virus	NN
cord-277417-f71jwdzj	332	4	mutate	mutate	VB
cord-277417-f71jwdzj	332	5	to	to	TO
cord-277417-f71jwdzj	332	6	cause	cause	VB
cord-277417-f71jwdzj	332	7	severe	severe	JJ
cord-277417-f71jwdzj	332	8	outbreaks	outbreak	NNS
cord-277417-f71jwdzj	332	9	?	?	.
cord-277417-f71jwdzj	333	1	Within	within	IN
cord-277417-f71jwdzj	333	2	-	-	HYPH
cord-277417-f71jwdzj	333	3	host	host	NN
cord-277417-f71jwdzj	333	4	parasite	parasite	NN
cord-277417-f71jwdzj	333	5	cooperation	cooperation	NN
cord-277417-f71jwdzj	333	6	and	and	CC
cord-277417-f71jwdzj	333	7	the	the	DT
cord-277417-f71jwdzj	333	8	evolution	evolution	NN
cord-277417-f71jwdzj	333	9	of	of	IN
cord-277417-f71jwdzj	333	10	virulence	virulence	NN
cord-277417-f71jwdzj	333	11	Myxoma	Myxoma	NNP
cord-277417-f71jwdzj	333	12	virus	virus	NN
cord-277417-f71jwdzj	333	13	and	and	CC
cord-277417-f71jwdzj	333	14	the	the	DT
cord-277417-f71jwdzj	333	15	leporipoxviruses	leporipoxviruse	NNS
cord-277417-f71jwdzj	333	16	:	:	:
cord-277417-f71jwdzj	333	17	an	an	DT
cord-277417-f71jwdzj	333	18	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	333	19	paradigm	paradigm	NN
cord-277417-f71jwdzj	333	20	Molecular	molecular	JJ
cord-277417-f71jwdzj	333	21	determinants	determinant	NNS
cord-277417-f71jwdzj	333	22	of	of	IN
cord-277417-f71jwdzj	333	23	Ebola	Ebola	NNP
cord-277417-f71jwdzj	333	24	virus	virus	NN
cord-277417-f71jwdzj	333	25	virulence	virulence	NN
cord-277417-f71jwdzj	333	26	in	in	IN
cord-277417-f71jwdzj	333	27	mice	mouse	NNS
cord-277417-f71jwdzj	334	1	The	the	DT
cord-277417-f71jwdzj	334	2	PDZ	pdz	NN
cord-277417-f71jwdzj	334	3	-	-	HYPH
cord-277417-f71jwdzj	334	4	binding	bind	VBG
cord-277417-f71jwdzj	334	5	motif	motif	NN
cord-277417-f71jwdzj	334	6	of	of	IN
cord-277417-f71jwdzj	334	7	severe	severe	JJ
cord-277417-f71jwdzj	334	8	acute	acute	JJ
cord-277417-f71jwdzj	334	9	respiratory	respiratory	JJ
cord-277417-f71jwdzj	334	10	syndrome	syndrome	NN
cord-277417-f71jwdzj	334	11	coronavirus	coronavirus	NN
cord-277417-f71jwdzj	334	12	envelope	envelope	NN
cord-277417-f71jwdzj	334	13	protein	protein	NN
cord-277417-f71jwdzj	334	14	is	be	VBZ
cord-277417-f71jwdzj	334	15	a	a	DT
cord-277417-f71jwdzj	334	16	determinant	determinant	NN
cord-277417-f71jwdzj	334	17	of	of	IN
cord-277417-f71jwdzj	334	18	viral	viral	JJ
cord-277417-f71jwdzj	334	19	pathogenesis	pathogenesis	NN
cord-277417-f71jwdzj	335	1	The	the	DT
cord-277417-f71jwdzj	335	2	role	role	NN
cord-277417-f71jwdzj	335	3	of	of	IN
cord-277417-f71jwdzj	335	4	VP1	vp1	NN
cord-277417-f71jwdzj	335	5	amino	amino	NN
cord-277417-f71jwdzj	335	6	acid	acid	NN
cord-277417-f71jwdzj	335	7	residue	residue	NN
cord-277417-f71jwdzj	335	8	145	145	CD
cord-277417-f71jwdzj	335	9	of	of	IN
cord-277417-f71jwdzj	335	10	enterovirus	enterovirus	NN
cord-277417-f71jwdzj	335	11	71	71	CD
cord-277417-f71jwdzj	335	12	in	in	IN
cord-277417-f71jwdzj	335	13	viral	viral	JJ
cord-277417-f71jwdzj	335	14	fitness	fitness	NN
cord-277417-f71jwdzj	335	15	and	and	CC
cord-277417-f71jwdzj	335	16	pathogenesis	pathogenesis	NN
cord-277417-f71jwdzj	335	17	in	in	IN
cord-277417-f71jwdzj	335	18	a	a	DT
cord-277417-f71jwdzj	335	19	cynomolgus	cynomolgus	NNP
cord-277417-f71jwdzj	335	20	monkey	monkey	NN
cord-277417-f71jwdzj	335	21	model	model	NN
cord-277417-f71jwdzj	335	22	Molecular	molecular	JJ
cord-277417-f71jwdzj	335	23	determinants	determinant	NNS
cord-277417-f71jwdzj	335	24	of	of	IN
cord-277417-f71jwdzj	335	25	infectious	infectious	JJ
cord-277417-f71jwdzj	335	26	pancreatic	pancreatic	JJ
cord-277417-f71jwdzj	335	27	necrosis	necrosis	NN
cord-277417-f71jwdzj	335	28	virus	virus	NN
cord-277417-f71jwdzj	335	29	virulence	virulence	NN
cord-277417-f71jwdzj	335	30	and	and	CC
cord-277417-f71jwdzj	335	31	cell	cell	NN
cord-277417-f71jwdzj	335	32	culture	culture	NN
cord-277417-f71jwdzj	335	33	adaptation	adaptation	NN
cord-277417-f71jwdzj	335	34	Virulence	virulence	NN
cord-277417-f71jwdzj	335	35	determinants	determinant	NNS
cord-277417-f71jwdzj	335	36	of	of	IN
cord-277417-f71jwdzj	335	37	pandemic	pandemic	NN
cord-277417-f71jwdzj	335	38	A(H1N1)2009	A(H1N1)2009	NNP
cord-277417-f71jwdzj	335	39	influenza	influenza	NN
cord-277417-f71jwdzj	335	40	virus	virus	NN
cord-277417-f71jwdzj	335	41	in	in	IN
cord-277417-f71jwdzj	335	42	a	a	DT
cord-277417-f71jwdzj	335	43	mouse	mouse	NN
cord-277417-f71jwdzj	335	44	model	model	NN
cord-277417-f71jwdzj	335	45	Reverse	Reverse	NNP
cord-277417-f71jwdzj	335	46	engineering	engineering	NN
cord-277417-f71jwdzj	335	47	field	field	NN
cord-277417-f71jwdzj	335	48	isolates	isolate	NNS
cord-277417-f71jwdzj	335	49	of	of	IN
cord-277417-f71jwdzj	335	50	myxoma	myxoma	NNP
cord-277417-f71jwdzj	335	51	virus	virus	NN
cord-277417-f71jwdzj	335	52	demonstrates	demonstrate	VBZ
cord-277417-f71jwdzj	335	53	that	that	IN
cord-277417-f71jwdzj	335	54	some	some	DT
cord-277417-f71jwdzj	335	55	gene	gene	NN
cord-277417-f71jwdzj	335	56	disruptions	disruption	NNS
cord-277417-f71jwdzj	335	57	or	or	CC
cord-277417-f71jwdzj	335	58	loss	loss	NN
cord-277417-f71jwdzj	335	59	of	of	IN
cord-277417-f71jwdzj	335	60	function	function	NN
cord-277417-f71jwdzj	335	61	do	do	VBP
cord-277417-f71jwdzj	335	62	not	not	RB
cord-277417-f71jwdzj	335	63	explain	explain	VB
cord-277417-f71jwdzj	335	64	virulence	virulence	NN
cord-277417-f71jwdzj	335	65	changes	change	NNS
cord-277417-f71jwdzj	335	66	observed	observe	VBN
cord-277417-f71jwdzj	335	67	in	in	IN
cord-277417-f71jwdzj	335	68	the	the	DT
cord-277417-f71jwdzj	335	69	field	field	NN
cord-277417-f71jwdzj	335	70	Using	use	VBG
cord-277417-f71jwdzj	335	71	ferrets	ferret	NNS
cord-277417-f71jwdzj	335	72	as	as	IN
cord-277417-f71jwdzj	335	73	an	an	DT
cord-277417-f71jwdzj	335	74	animal	animal	NN
cord-277417-f71jwdzj	335	75	model	model	NN
cord-277417-f71jwdzj	335	76	for	for	IN
cord-277417-f71jwdzj	335	77	investigating	investigate	VBG
cord-277417-f71jwdzj	335	78	influenza	influenza	NN
cord-277417-f71jwdzj	335	79	antiviral	antiviral	JJ
cord-277417-f71jwdzj	335	80	effectiveness	effectiveness	NN
cord-277417-f71jwdzj	335	81	Virus	virus	NN
cord-277417-f71jwdzj	335	82	genomes	genome	NNS
cord-277417-f71jwdzj	335	83	reveal	reveal	VBP
cord-277417-f71jwdzj	335	84	factors	factor	NNS
cord-277417-f71jwdzj	335	85	that	that	WDT
cord-277417-f71jwdzj	335	86	spread	spread	VBP
cord-277417-f71jwdzj	335	87	and	and	CC
cord-277417-f71jwdzj	335	88	sustained	sustain	VBD
cord-277417-f71jwdzj	335	89	the	the	DT
cord-277417-f71jwdzj	335	90	Ebola	Ebola	NNP
cord-277417-f71jwdzj	335	91	epidemic	epidemic	NN
cord-277417-f71jwdzj	335	92	Epidemic	epidemic	NN
cord-277417-f71jwdzj	335	93	establishment	establishment	NN
cord-277417-f71jwdzj	335	94	and	and	CC
cord-277417-f71jwdzj	335	95	cryptic	cryptic	JJ
cord-277417-f71jwdzj	335	96	transmission	transmission	NN
cord-277417-f71jwdzj	335	97	of	of	IN
cord-277417-f71jwdzj	335	98	Zika	Zika	NNP
cord-277417-f71jwdzj	335	99	virus	virus	NN
cord-277417-f71jwdzj	335	100	in	in	IN
cord-277417-f71jwdzj	335	101	Brazil	Brazil	NNP
cord-277417-f71jwdzj	335	102	and	and	CC
cord-277417-f71jwdzj	335	103	the	the	DT
cord-277417-f71jwdzj	335	104	Americas	Americas	NNPS
cord-277417-f71jwdzj	336	1	The	the	DT
cord-277417-f71jwdzj	336	2	evolution	evolution	NN
cord-277417-f71jwdzj	336	3	of	of	IN
cord-277417-f71jwdzj	336	4	Ebola	Ebola	NNP
cord-277417-f71jwdzj	336	5	virus	virus	NN
cord-277417-f71jwdzj	336	6	:	:	:
cord-277417-f71jwdzj	336	7	insights	insight	NNS
cord-277417-f71jwdzj	336	8	from	from	IN
cord-277417-f71jwdzj	336	9	the	the	DT
cord-277417-f71jwdzj	336	10	2013	2013	CD
cord-277417-f71jwdzj	336	11	-	-	SYM
cord-277417-f71jwdzj	336	12	2016	2016	CD
cord-277417-f71jwdzj	336	13	epidemic	epidemic	NN
cord-277417-f71jwdzj	336	14	Nextstrain	Nextstrain	NNP
cord-277417-f71jwdzj	336	15	:	:	:
cord-277417-f71jwdzj	336	16	real	real	JJ
cord-277417-f71jwdzj	336	17	-	-	HYPH
cord-277417-f71jwdzj	336	18	time	time	NN
cord-277417-f71jwdzj	336	19	tracking	tracking	NN
cord-277417-f71jwdzj	336	20	of	of	IN
cord-277417-f71jwdzj	336	21	pathogen	pathogen	NN
cord-277417-f71jwdzj	336	22	evolution	evolution	NN
cord-277417-f71jwdzj	337	1	Can	Can	MD
cord-277417-f71jwdzj	337	2	we	-PRON-	PRP
cord-277417-f71jwdzj	337	3	read	read	VB
cord-277417-f71jwdzj	337	4	the	the	DT
cord-277417-f71jwdzj	337	5	future	future	NN
cord-277417-f71jwdzj	337	6	from	from	IN
cord-277417-f71jwdzj	337	7	a	a	DT
cord-277417-f71jwdzj	337	8	tree	tree	NN
cord-277417-f71jwdzj	337	9	?	?	.
cord-277417-f71jwdzj	338	1	eLife	eLife	NNP
cord-277417-f71jwdzj	338	2	Predicting	predict	VBG
cord-277417-f71jwdzj	338	3	evolution	evolution	NN
cord-277417-f71jwdzj	338	4	from	from	IN
cord-277417-f71jwdzj	338	5	the	the	DT
cord-277417-f71jwdzj	338	6	shape	shape	NN
cord-277417-f71jwdzj	338	7	of	of	IN
cord-277417-f71jwdzj	338	8	genealogical	genealogical	JJ
cord-277417-f71jwdzj	338	9	trees	tree	NNS
cord-277417-f71jwdzj	339	1	This	this	DT
cord-277417-f71jwdzj	339	2	study	study	NN
cord-277417-f71jwdzj	339	3	combines	combine	VBZ
cord-277417-f71jwdzj	339	4	experimental	experimental	JJ
cord-277417-f71jwdzj	339	5	cross	cross	JJ
cord-277417-f71jwdzj	339	6	-	-	JJ
cord-277417-f71jwdzj	339	7	species	species	JJ
cord-277417-f71jwdzj	339	8	transmission	transmission	NN
cord-277417-f71jwdzj	339	9	and	and	CC
cord-277417-f71jwdzj	339	10	phylogenetics	phylogenetic	NNS
cord-277417-f71jwdzj	339	11	to	to	TO
cord-277417-f71jwdzj	339	12	reveal	reveal	VB
cord-277417-f71jwdzj	339	13	the	the	DT
cord-277417-f71jwdzj	339	14	nature	nature	NN
cord-277417-f71jwdzj	339	15	of	of	IN
cord-277417-f71jwdzj	339	16	virulence	virulence	NN
cord-277417-f71jwdzj	339	17	evolution	evolution	NN
cord-277417-f71jwdzj	339	18	in	in	IN
cord-277417-f71jwdzj	339	19	a	a	DT
cord-277417-f71jwdzj	339	20	Drosophila	Drosophila	NNP
cord-277417-f71jwdzj	339	21	virus	virus	NN
cord-277417-f71jwdzj	339	22	Differential	differential	JJ
cord-277417-f71jwdzj	339	23	infection	infection	NN
cord-277417-f71jwdzj	339	24	patterns	pattern	NNS
cord-277417-f71jwdzj	339	25	and	and	CC
cord-277417-f71jwdzj	339	26	recent	recent	JJ
cord-277417-f71jwdzj	339	27	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	339	28	origins	origin	NNS
cord-277417-f71jwdzj	339	29	of	of	IN
cord-277417-f71jwdzj	339	30	equine	equine	JJ
cord-277417-f71jwdzj	339	31	hepaciviruses	hepaciviruse	NNS
cord-277417-f71jwdzj	339	32	in	in	IN
cord-277417-f71jwdzj	339	33	donkeys	donkey	NNS
cord-277417-f71jwdzj	339	34	Fruit	Fruit	NNP
cord-277417-f71jwdzj	339	35	bats	bat	NNS
cord-277417-f71jwdzj	339	36	as	as	IN
cord-277417-f71jwdzj	339	37	reservoirs	reservoir	NNS
cord-277417-f71jwdzj	339	38	of	of	IN
cord-277417-f71jwdzj	339	39	Ebola	Ebola	NNP
cord-277417-f71jwdzj	339	40	virus	virus	NN
cord-277417-f71jwdzj	339	41	Bat	bat	NN
cord-277417-f71jwdzj	339	42	-	-	HYPH
cord-277417-f71jwdzj	339	43	man	man	NN
cord-277417-f71jwdzj	339	44	disease	disease	NN
cord-277417-f71jwdzj	339	45	transmission	transmission	NN
cord-277417-f71jwdzj	339	46	:	:	:
cord-277417-f71jwdzj	339	47	zoonotic	zoonotic	JJ
cord-277417-f71jwdzj	339	48	pathogens	pathogen	NNS
cord-277417-f71jwdzj	339	49	from	from	IN
cord-277417-f71jwdzj	339	50	wildlife	wildlife	NN
cord-277417-f71jwdzj	339	51	reservoirs	reservoir	NNS
cord-277417-f71jwdzj	339	52	to	to	IN
cord-277417-f71jwdzj	340	1	human	human	JJ
cord-277417-f71jwdzj	340	2	populations	population	NNS
cord-277417-f71jwdzj	340	3	Evolution	Evolution	NNP
cord-277417-f71jwdzj	340	4	of	of	IN
cord-277417-f71jwdzj	340	5	canine	canine	JJ
cord-277417-f71jwdzj	340	6	parvovirus	parvovirus	NN
cord-277417-f71jwdzj	340	7	involved	involve	VBN
cord-277417-f71jwdzj	340	8	loss	loss	NN
cord-277417-f71jwdzj	340	9	and	and	CC
cord-277417-f71jwdzj	340	10	gain	gain	NN
cord-277417-f71jwdzj	340	11	of	of	IN
cord-277417-f71jwdzj	340	12	feline	feline	JJ
cord-277417-f71jwdzj	340	13	host	host	NN
cord-277417-f71jwdzj	340	14	range	range	NN
cord-277417-f71jwdzj	340	15	Host	host	NN
cord-277417-f71jwdzj	340	16	-	-	HYPH
cord-277417-f71jwdzj	340	17	specific	specific	JJ
cord-277417-f71jwdzj	340	18	parvovirus	parvovirus	NN
cord-277417-f71jwdzj	340	19	evolution	evolution	NN
cord-277417-f71jwdzj	340	20	in	in	IN
cord-277417-f71jwdzj	340	21	nature	nature	NN
cord-277417-f71jwdzj	340	22	is	be	VBZ
cord-277417-f71jwdzj	340	23	recapitulated	recapitulate	VBN
cord-277417-f71jwdzj	340	24	by	by	IN
cord-277417-f71jwdzj	340	25	in	in	FW
cord-277417-f71jwdzj	340	26	vitro	vitro	FW
cord-277417-f71jwdzj	340	27	adaptation	adaptation	NN
cord-277417-f71jwdzj	340	28	to	to	IN
cord-277417-f71jwdzj	340	29	different	different	JJ
cord-277417-f71jwdzj	340	30	carnivore	carnivore	NN
cord-277417-f71jwdzj	340	31	species	specie	NNS
cord-277417-f71jwdzj	341	1	Virological	virological	JJ
cord-277417-f71jwdzj	341	2	factors	factor	NNS
cord-277417-f71jwdzj	341	3	that	that	WDT
cord-277417-f71jwdzj	341	4	increase	increase	VBP
cord-277417-f71jwdzj	341	5	the	the	DT
cord-277417-f71jwdzj	341	6	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	341	7	of	of	IN
cord-277417-f71jwdzj	341	8	emerging	emerge	VBG
cord-277417-f71jwdzj	341	9	human	human	NN
cord-277417-f71jwdzj	341	10	viruses	virus	NNS
cord-277417-f71jwdzj	341	11	Coevolution	Coevolution	NNP
cord-277417-f71jwdzj	341	12	of	of	IN
cord-277417-f71jwdzj	341	13	hosts	host	NNS
cord-277417-f71jwdzj	341	14	and	and	CC
cord-277417-f71jwdzj	341	15	parasites	parasite	NNS
cord-277417-f71jwdzj	341	16	Evolution	Evolution	NNP
cord-277417-f71jwdzj	341	17	in	in	IN
cord-277417-f71jwdzj	341	18	Health	Health	NNP
cord-277417-f71jwdzj	341	19	and	and	CC
cord-277417-f71jwdzj	341	20	Disease	Disease	NNP
cord-277417-f71jwdzj	341	21	Challenging	challenge	VBG
cord-277417-f71jwdzj	341	22	the	the	DT
cord-277417-f71jwdzj	341	23	trade	trade	NN
cord-277417-f71jwdzj	341	24	-	-	HYPH
cord-277417-f71jwdzj	341	25	off	off	RP
cord-277417-f71jwdzj	341	26	model	model	NN
cord-277417-f71jwdzj	341	27	for	for	IN
cord-277417-f71jwdzj	341	28	the	the	DT
cord-277417-f71jwdzj	341	29	evolution	evolution	NN
cord-277417-f71jwdzj	341	30	of	of	IN
cord-277417-f71jwdzj	341	31	virulence	virulence	NN
cord-277417-f71jwdzj	341	32	:	:	:
cord-277417-f71jwdzj	341	33	is	be	VBZ
cord-277417-f71jwdzj	341	34	virulence	virulence	NN
cord-277417-f71jwdzj	341	35	management	management	NN
cord-277417-f71jwdzj	341	36	feasible	feasible	JJ
cord-277417-f71jwdzj	341	37	?	?	.
cord-277417-f71jwdzj	342	1	Evolution	evolution	NN
cord-277417-f71jwdzj	342	2	of	of	IN
cord-277417-f71jwdzj	342	3	Infectious	Infectious	NNP
cord-277417-f71jwdzj	342	4	Diseases	Diseases	NNPS
cord-277417-f71jwdzj	343	1	The	the	DT
cord-277417-f71jwdzj	343	2	evolution	evolution	NN
cord-277417-f71jwdzj	343	3	of	of	IN
cord-277417-f71jwdzj	343	4	virulence	virulence	NN
cord-277417-f71jwdzj	343	5	Relationship	relationship	NN
cord-277417-f71jwdzj	343	6	between	between	IN
cord-277417-f71jwdzj	343	7	within	within	IN
cord-277417-f71jwdzj	343	8	-	-	HYPH
cord-277417-f71jwdzj	343	9	host	host	NN
cord-277417-f71jwdzj	343	10	fitness	fitness	NN
cord-277417-f71jwdzj	343	11	and	and	CC
cord-277417-f71jwdzj	343	12	virulence	virulence	NN
cord-277417-f71jwdzj	343	13	in	in	IN
cord-277417-f71jwdzj	343	14	the	the	DT
cord-277417-f71jwdzj	343	15	vesicular	vesicular	JJ
cord-277417-f71jwdzj	343	16	stomatitis	stomatitis	NN
cord-277417-f71jwdzj	343	17	virus	virus	NN
cord-277417-f71jwdzj	343	18	:	:	:
cord-277417-f71jwdzj	343	19	correlation	correlation	NN
cord-277417-f71jwdzj	343	20	with	with	IN
cord-277417-f71jwdzj	343	21	partial	partial	JJ
cord-277417-f71jwdzj	343	22	decoupling	decoupling	NN
cord-277417-f71jwdzj	343	23	This	this	DT
cord-277417-f71jwdzj	343	24	article	article	NN
cord-277417-f71jwdzj	343	25	argues	argue	VBZ
cord-277417-f71jwdzj	343	26	that	that	IN
cord-277417-f71jwdzj	343	27	current	current	JJ
cord-277417-f71jwdzj	343	28	formulations	formulation	NNS
cord-277417-f71jwdzj	343	29	of	of	IN
cord-277417-f71jwdzj	343	30	R	r	NN
cord-277417-f71jwdzj	343	31	0	0	CD
cord-277417-f71jwdzj	343	32	are	be	VBP
cord-277417-f71jwdzj	343	33	too	too	RB
cord-277417-f71jwdzj	343	34	simplistic	simplistic	JJ
cord-277417-f71jwdzj	343	35	to	to	TO
cord-277417-f71jwdzj	343	36	understand	understand	VB
cord-277417-f71jwdzj	343	37	pathogen	pathogen	NN
cord-277417-f71jwdzj	343	38	evolution	evolution	NN
cord-277417-f71jwdzj	343	39	and	and	CC
cord-277417-f71jwdzj	343	40	that	that	IN
cord-277417-f71jwdzj	343	41	a	a	DT
cord-277417-f71jwdzj	343	42	more	more	RBR
cord-277417-f71jwdzj	343	43	complex	complex	JJ
cord-277417-f71jwdzj	343	44	Variation	variation	NN
cord-277417-f71jwdzj	343	45	in	in	IN
cord-277417-f71jwdzj	343	46	HIV-1	HIV-1	NNP
cord-277417-f71jwdzj	343	47	set	set	NN
cord-277417-f71jwdzj	343	48	-	-	HYPH
cord-277417-f71jwdzj	343	49	point	point	NN
cord-277417-f71jwdzj	343	50	viral	viral	JJ
cord-277417-f71jwdzj	343	51	load	load	NN
cord-277417-f71jwdzj	343	52	:	:	:
cord-277417-f71jwdzj	343	53	epidemiological	epidemiological	JJ
cord-277417-f71jwdzj	343	54	analysis	analysis	NN
cord-277417-f71jwdzj	343	55	and	and	CC
cord-277417-f71jwdzj	343	56	an	an	DT
cord-277417-f71jwdzj	343	57	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	343	58	hypothesis	hypothesis	NN
cord-277417-f71jwdzj	343	59	Virulence	virulence	NN
cord-277417-f71jwdzj	343	60	evolution	evolution	NN
cord-277417-f71jwdzj	343	61	and	and	CC
cord-277417-f71jwdzj	343	62	the	the	DT
cord-277417-f71jwdzj	343	63	trade	trade	NN
cord-277417-f71jwdzj	343	64	-	-	HYPH
cord-277417-f71jwdzj	343	65	off	off	RP
cord-277417-f71jwdzj	343	66	hypothesis	hypothesis	NN
cord-277417-f71jwdzj	343	67	:	:	:
cord-277417-f71jwdzj	343	68	history	history	NN
cord-277417-f71jwdzj	343	69	,	,	,
cord-277417-f71jwdzj	343	70	current	current	JJ
cord-277417-f71jwdzj	343	71	state	state	NN
cord-277417-f71jwdzj	343	72	of	of	IN
cord-277417-f71jwdzj	343	73	affairs	affair	NNS
cord-277417-f71jwdzj	343	74	&	&	CC
cord-277417-f71jwdzj	343	75	the	the	DT
cord-277417-f71jwdzj	343	76	future	future	NN
cord-277417-f71jwdzj	344	1	This	this	DT
cord-277417-f71jwdzj	344	2	paper	paper	NN
cord-277417-f71jwdzj	344	3	provides	provide	VBZ
cord-277417-f71jwdzj	344	4	an	an	DT
cord-277417-f71jwdzj	344	5	overview	overview	NN
cord-277417-f71jwdzj	344	6	of	of	IN
cord-277417-f71jwdzj	344	7	the	the	DT
cord-277417-f71jwdzj	344	8	theory	theory	NN
cord-277417-f71jwdzj	344	9	that	that	IN
cord-277417-f71jwdzj	344	10	there	there	EX
cord-277417-f71jwdzj	344	11	is	be	VBZ
cord-277417-f71jwdzj	344	12	a	a	DT
cord-277417-f71jwdzj	344	13	trade	trade	NN
cord-277417-f71jwdzj	344	14	-	-	HYPH
cord-277417-f71jwdzj	344	15	off	off	NN
cord-277417-f71jwdzj	344	16	between	between	IN
cord-277417-f71jwdzj	344	17	virulence	virulence	NN
cord-277417-f71jwdzj	344	18	and	and	CC
cord-277417-f71jwdzj	344	19	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	344	20	,	,	,
cord-277417-f71jwdzj	344	21	highlighting	highlight	VBG
cord-277417-f71jwdzj	344	22	areas	area	NNS
cord-277417-f71jwdzj	344	23	in	in	IN
cord-277417-f71jwdzj	344	24	which	which	WDT
cord-277417-f71jwdzj	344	25	the	the	DT
cord-277417-f71jwdzj	344	26	theory	theory	NN
cord-277417-f71jwdzj	344	27	has	have	VBZ
cord-277417-f71jwdzj	344	28	been	be	VBN
cord-277417-f71jwdzj	344	29	challenged	challenge	VBN
cord-277417-f71jwdzj	344	30	and	and	CC
cord-277417-f71jwdzj	344	31	extended	extend	VBN
cord-277417-f71jwdzj	344	32	over	over	IN
cord-277417-f71jwdzj	344	33	the	the	DT
cord-277417-f71jwdzj	344	34	past	past	JJ
cord-277417-f71jwdzj	344	35	20	20	CD
cord-277417-f71jwdzj	344	36	years	year	NNS
cord-277417-f71jwdzj	344	37	Adaptive	adaptive	JJ
cord-277417-f71jwdzj	344	38	virulence	virulence	NN
cord-277417-f71jwdzj	344	39	evolution	evolution	NN
cord-277417-f71jwdzj	344	40	:	:	:
cord-277417-f71jwdzj	344	41	the	the	DT
cord-277417-f71jwdzj	344	42	good	good	JJ
cord-277417-f71jwdzj	344	43	old	old	JJ
cord-277417-f71jwdzj	344	44	fitness	fitness	NN
cord-277417-f71jwdzj	344	45	-	-	HYPH
cord-277417-f71jwdzj	344	46	based	base	VBN
cord-277417-f71jwdzj	344	47	approach	approach	NN
cord-277417-f71jwdzj	344	48	Virulence	virulence	NN
cord-277417-f71jwdzj	344	49	and	and	CC
cord-277417-f71jwdzj	344	50	transmissibility	transmissibility	NN
cord-277417-f71jwdzj	344	51	of	of	IN
cord-277417-f71jwdzj	344	52	pathogens	pathogen	NNS
cord-277417-f71jwdzj	344	53	:	:	:
cord-277417-f71jwdzj	344	54	what	what	WP
cord-277417-f71jwdzj	344	55	is	be	VBZ
cord-277417-f71jwdzj	344	56	the	the	DT
cord-277417-f71jwdzj	344	57	relationship	relationship	NN
cord-277417-f71jwdzj	344	58	?	?	.
cord-277417-f71jwdzj	345	1	Size	size	NN
cord-277417-f71jwdzj	345	2	of	of	IN
cord-277417-f71jwdzj	345	3	genetic	genetic	JJ
cord-277417-f71jwdzj	345	4	bottlenecks	bottleneck	NNS
cord-277417-f71jwdzj	345	5	leading	lead	VBG
cord-277417-f71jwdzj	345	6	to	to	IN
cord-277417-f71jwdzj	345	7	virus	virus	NN
cord-277417-f71jwdzj	345	8	fitness	fitness	NN
cord-277417-f71jwdzj	345	9	loss	loss	NN
cord-277417-f71jwdzj	345	10	is	be	VBZ
cord-277417-f71jwdzj	345	11	determined	determine	VBN
cord-277417-f71jwdzj	345	12	by	by	IN
cord-277417-f71jwdzj	345	13	mean	mean	JJ
cord-277417-f71jwdzj	345	14	initial	initial	JJ
cord-277417-f71jwdzj	345	15	population	population	NN
cord-277417-f71jwdzj	345	16	fitness	fitness	NN
cord-277417-f71jwdzj	345	17	Virulence	Virulence	NNP
cord-277417-f71jwdzj	345	18	evolution	evolution	NN
cord-277417-f71jwdzj	345	19	of	of	IN
cord-277417-f71jwdzj	345	20	a	a	DT
cord-277417-f71jwdzj	345	21	generalist	generalist	JJ
cord-277417-f71jwdzj	345	22	plant	plant	NN
cord-277417-f71jwdzj	345	23	virus	virus	NN
cord-277417-f71jwdzj	345	24	in	in	IN
cord-277417-f71jwdzj	345	25	a	a	DT
cord-277417-f71jwdzj	345	26	heterogeneous	heterogeneous	JJ
cord-277417-f71jwdzj	345	27	host	host	NN
cord-277417-f71jwdzj	345	28	system	system	NN
cord-277417-f71jwdzj	345	29	Virus	virus	NN
cord-277417-f71jwdzj	345	30	biocontrol	biocontrol	NN
cord-277417-f71jwdzj	345	31	:	:	:
cord-277417-f71jwdzj	345	32	grand	grand	JJ
cord-277417-f71jwdzj	345	33	experiments	experiment	NNS
cord-277417-f71jwdzj	345	34	in	in	IN
cord-277417-f71jwdzj	345	35	disease	disease	NN
cord-277417-f71jwdzj	345	36	emergence	emergence	NN
cord-277417-f71jwdzj	345	37	and	and	CC
cord-277417-f71jwdzj	345	38	evolution	evolution	NN
cord-277417-f71jwdzj	345	39	High	high	JJ
cord-277417-f71jwdzj	345	40	virulence	virulence	NN
cord-277417-f71jwdzj	345	41	does	do	VBZ
cord-277417-f71jwdzj	345	42	not	not	RB
cord-277417-f71jwdzj	345	43	necessarily	necessarily	RB
cord-277417-f71jwdzj	345	44	impede	impede	VB
cord-277417-f71jwdzj	345	45	viral	viral	JJ
cord-277417-f71jwdzj	345	46	adaptation	adaptation	NN
cord-277417-f71jwdzj	345	47	to	to	IN
cord-277417-f71jwdzj	345	48	a	a	DT
cord-277417-f71jwdzj	345	49	new	new	JJ
cord-277417-f71jwdzj	345	50	host	host	NN
cord-277417-f71jwdzj	345	51	:	:	:
cord-277417-f71jwdzj	345	52	a	a	DT
cord-277417-f71jwdzj	345	53	case	case	NN
cord-277417-f71jwdzj	345	54	study	study	NN
cord-277417-f71jwdzj	345	55	using	use	VBG
cord-277417-f71jwdzj	345	56	a	a	DT
cord-277417-f71jwdzj	345	57	plant	plant	NN
cord-277417-f71jwdzj	345	58	RNA	RNA	NNP
cord-277417-f71jwdzj	345	59	virus	virus	NN
cord-277417-f71jwdzj	345	60	Virulence	virulence	NN
cord-277417-f71jwdzj	345	61	and	and	CC
cord-277417-f71jwdzj	345	62	competitive	competitive	JJ
cord-277417-f71jwdzj	345	63	ability	ability	NN
cord-277417-f71jwdzj	345	64	in	in	IN
cord-277417-f71jwdzj	345	65	genetically	genetically	RB
cord-277417-f71jwdzj	345	66	diverse	diverse	JJ
cord-277417-f71jwdzj	345	67	malaria	malaria	NN
cord-277417-f71jwdzj	345	68	infections	infection	NNS
cord-277417-f71jwdzj	345	69	Short	short	JJ
cord-277417-f71jwdzj	345	70	-	-	HYPH
cord-277417-f71jwdzj	345	71	sighted	sighted	JJ
cord-277417-f71jwdzj	345	72	evolution	evolution	NN
cord-277417-f71jwdzj	345	73	and	and	CC
cord-277417-f71jwdzj	345	74	the	the	DT
cord-277417-f71jwdzj	345	75	virulence	virulence	NN
cord-277417-f71jwdzj	345	76	of	of	IN
cord-277417-f71jwdzj	345	77	pathogenic	pathogenic	JJ
cord-277417-f71jwdzj	345	78	microorganisms	microorganism	NNS
cord-277417-f71jwdzj	345	79	Epidemic	epidemic	NN
cord-277417-f71jwdzj	345	80	dynamics	dynamic	NNS
cord-277417-f71jwdzj	345	81	at	at	IN
cord-277417-f71jwdzj	345	82	the	the	DT
cord-277417-f71jwdzj	345	83	human	human	JJ
cord-277417-f71jwdzj	345	84	-	-	HYPH
cord-277417-f71jwdzj	345	85	animal	animal	NN
cord-277417-f71jwdzj	345	86	interface	interface	NN
cord-277417-f71jwdzj	345	87	Transmission	transmission	NN
cord-277417-f71jwdzj	345	88	bottlenecks	bottleneck	NNS
cord-277417-f71jwdzj	345	89	as	as	IN
cord-277417-f71jwdzj	345	90	determinants	determinant	NNS
cord-277417-f71jwdzj	345	91	of	of	IN
cord-277417-f71jwdzj	345	92	virulence	virulence	NN
cord-277417-f71jwdzj	345	93	in	in	IN
cord-277417-f71jwdzj	345	94	rapidly	rapidly	RB
cord-277417-f71jwdzj	345	95	evolving	evolve	VBG
cord-277417-f71jwdzj	345	96	pathogens	pathogen	NNS
cord-277417-f71jwdzj	345	97	Transient	transient	JJ
cord-277417-f71jwdzj	345	98	virulence	virulence	NN
cord-277417-f71jwdzj	345	99	of	of	IN
cord-277417-f71jwdzj	345	100	emerging	emerge	VBG
cord-277417-f71jwdzj	345	101	pathogens	pathogen	NNS
cord-277417-f71jwdzj	345	102	Evolution	evolution	NN
cord-277417-f71jwdzj	345	103	of	of	IN
cord-277417-f71jwdzj	345	104	virulence	virulence	NN
cord-277417-f71jwdzj	345	105	in	in	IN
cord-277417-f71jwdzj	345	106	opportunistic	opportunistic	JJ
cord-277417-f71jwdzj	345	107	pathogens	pathogen	NNS
cord-277417-f71jwdzj	345	108	:	:	:
cord-277417-f71jwdzj	345	109	generalism	generalism	NN
cord-277417-f71jwdzj	345	110	,	,	,
cord-277417-f71jwdzj	345	111	plasticity	plasticity	NN
cord-277417-f71jwdzj	345	112	,	,	,
cord-277417-f71jwdzj	345	113	and	and	CC
cord-277417-f71jwdzj	345	114	control	control	VB
cord-277417-f71jwdzj	345	115	This	this	DT
cord-277417-f71jwdzj	345	116	article	article	NN
cord-277417-f71jwdzj	345	117	discusses	discuss	VBZ
cord-277417-f71jwdzj	345	118	what	what	WDT
cord-277417-f71jwdzj	345	119	aspects	aspect	NNS
cord-277417-f71jwdzj	345	120	of	of	IN
cord-277417-f71jwdzj	345	121	virus	virus	NN
cord-277417-f71jwdzj	345	122	evolution	evolution	NN
cord-277417-f71jwdzj	345	123	might	may	MD
cord-277417-f71jwdzj	345	124	be	be	VB
cord-277417-f71jwdzj	345	125	predictable	predictable	JJ
cord-277417-f71jwdzj	345	126	,	,	,
cord-277417-f71jwdzj	345	127	including	include	VBG
cord-277417-f71jwdzj	345	128	virulence	virulence	NN
cord-277417-f71jwdzj	345	129	,	,	,
cord-277417-f71jwdzj	345	130	and	and	CC
cord-277417-f71jwdzj	345	131	how	how	WRB
cord-277417-f71jwdzj	345	132	this	this	DT
cord-277417-f71jwdzj	345	133	can	can	MD
cord-277417-f71jwdzj	345	134	be	be	VB
cord-277417-f71jwdzj	345	135	tested	test	VBN
cord-277417-f71jwdzj	345	136	and	and	CC
cord-277417-f71jwdzj	345	137	highlights	highlight	VBZ
cord-277417-f71jwdzj	345	138	the	the	DT
cord-277417-f71jwdzj	345	139	importance	importance	NN
cord-277417-f71jwdzj	345	140	of	of	IN
cord-277417-f71jwdzj	345	141	parallel	parallel	JJ
cord-277417-f71jwdzj	345	142	evolution	evolution	NN
cord-277417-f71jwdzj	345	143	as	as	IN
cord-277417-f71jwdzj	345	144	a	a	DT
cord-277417-f71jwdzj	345	145	marker	marker	NN
cord-277417-f71jwdzj	345	146	of	of	IN
cord-277417-f71jwdzj	345	147	adaptation	adaptation	NN
cord-277417-f71jwdzj	345	148	Mutation	mutation	NN
cord-277417-f71jwdzj	345	149	driven	drive	VBD
cord-277417-f71jwdzj	345	150	parallel	parallel	JJ
cord-277417-f71jwdzj	345	151	evolution	evolution	NN
cord-277417-f71jwdzj	345	152	during	during	IN
cord-277417-f71jwdzj	345	153	viral	viral	JJ
cord-277417-f71jwdzj	345	154	adaptation	adaptation	NN
cord-277417-f71jwdzj	346	1	Convergent	convergent	JJ
cord-277417-f71jwdzj	346	2	evolution	evolution	NN
cord-277417-f71jwdzj	346	3	of	of	IN
cord-277417-f71jwdzj	346	4	lysozyme	lysozyme	NNS
cord-277417-f71jwdzj	346	5	sequences	sequence	NNS
cord-277417-f71jwdzj	346	6	?	?	.
cord-277417-f71jwdzj	347	1	Population	population	NN
cord-277417-f71jwdzj	347	2	size	size	NN
cord-277417-f71jwdzj	347	3	changes	change	NNS
cord-277417-f71jwdzj	347	4	and	and	CC
cord-277417-f71jwdzj	347	5	selection	selection	NN
cord-277417-f71jwdzj	347	6	drive	drive	NN
cord-277417-f71jwdzj	347	7	patterns	pattern	NNS
cord-277417-f71jwdzj	347	8	of	of	IN
cord-277417-f71jwdzj	347	9	parallel	parallel	JJ
cord-277417-f71jwdzj	347	10	evolution	evolution	NN
cord-277417-f71jwdzj	347	11	in	in	IN
cord-277417-f71jwdzj	347	12	a	a	DT
cord-277417-f71jwdzj	347	13	host	host	NN
cord-277417-f71jwdzj	347	14	-	-	HYPH
cord-277417-f71jwdzj	347	15	virus	virus	NN
cord-277417-f71jwdzj	347	16	system	system	NN
cord-277417-f71jwdzj	348	1	A	a	DT
cord-277417-f71jwdzj	348	2	single	single	JJ
cord-277417-f71jwdzj	348	3	positively	positively	RB
cord-277417-f71jwdzj	348	4	selected	select	VBN
cord-277417-f71jwdzj	348	5	West	West	NNP
cord-277417-f71jwdzj	348	6	Nile	Nile	NNP
cord-277417-f71jwdzj	348	7	viral	viral	JJ
cord-277417-f71jwdzj	348	8	mutation	mutation	NN
cord-277417-f71jwdzj	348	9	confers	confer	VBZ
cord-277417-f71jwdzj	348	10	increased	increase	VBN
cord-277417-f71jwdzj	348	11	avian	avian	JJ
cord-277417-f71jwdzj	348	12	virogenesis	virogenesis	NN
cord-277417-f71jwdzj	348	13	in	in	IN
cord-277417-f71jwdzj	348	14	American	american	JJ
cord-277417-f71jwdzj	348	15	crows	crow	NNS
cord-277417-f71jwdzj	348	16	This	this	DT
cord-277417-f71jwdzj	348	17	study	study	NN
cord-277417-f71jwdzj	348	18	demonstrates	demonstrate	VBZ
cord-277417-f71jwdzj	348	19	that	that	IN
cord-277417-f71jwdzj	348	20	positive	positive	JJ
cord-277417-f71jwdzj	348	21	selection	selection	NN
cord-277417-f71jwdzj	348	22	on	on	IN
cord-277417-f71jwdzj	348	23	a	a	DT
cord-277417-f71jwdzj	348	24	single	single	JJ
cord-277417-f71jwdzj	348	25	amino	amino	NN
cord-277417-f71jwdzj	348	26	acid	acid	NN
cord-277417-f71jwdzj	348	27	substitution	substitution	NN
cord-277417-f71jwdzj	348	28	within	within	IN
cord-277417-f71jwdzj	348	29	the	the	DT
cord-277417-f71jwdzj	348	30	genome	genome	NN
cord-277417-f71jwdzj	348	31	of	of	IN
cord-277417-f71jwdzj	348	32	WNV	WNV	NNP
cord-277417-f71jwdzj	348	33	was	be	VBD
cord-277417-f71jwdzj	348	34	responsible	responsible	JJ
cord-277417-f71jwdzj	348	35	for	for	IN
cord-277417-f71jwdzj	348	36	increased	increase	VBN
cord-277417-f71jwdzj	348	37	virulence	virulence	NN
cord-277417-f71jwdzj	348	38	in	in	IN
cord-277417-f71jwdzj	348	39	the	the	DT
cord-277417-f71jwdzj	348	40	American	american	JJ
cord-277417-f71jwdzj	348	41	crow	crow	NN
cord-277417-f71jwdzj	348	42	Host	host	NN
cord-277417-f71jwdzj	348	43	shifts	shift	NNS
cord-277417-f71jwdzj	348	44	result	result	VBP
cord-277417-f71jwdzj	348	45	in	in	IN
cord-277417-f71jwdzj	348	46	parallel	parallel	JJ
cord-277417-f71jwdzj	348	47	genetic	genetic	JJ
cord-277417-f71jwdzj	348	48	changes	change	NNS
cord-277417-f71jwdzj	348	49	when	when	WRB
cord-277417-f71jwdzj	348	50	viruses	virus	NNS
cord-277417-f71jwdzj	348	51	evolve	evolve	VBP
cord-277417-f71jwdzj	348	52	in	in	IN
cord-277417-f71jwdzj	348	53	closely	closely	RB
cord-277417-f71jwdzj	348	54	related	relate	VBN
cord-277417-f71jwdzj	348	55	species	specie	NNS
cord-277417-f71jwdzj	349	1	Datamonkey	Datamonkey	NNP
cord-277417-f71jwdzj	349	2	2.0	2.0	CD
cord-277417-f71jwdzj	349	3	:	:	:
cord-277417-f71jwdzj	349	4	a	a	DT
cord-277417-f71jwdzj	349	5	modern	modern	JJ
cord-277417-f71jwdzj	349	6	web	web	NN
cord-277417-f71jwdzj	349	7	application	application	NN
cord-277417-f71jwdzj	349	8	for	for	IN
cord-277417-f71jwdzj	349	9	characterizing	characterize	VBG
cord-277417-f71jwdzj	349	10	selective	selective	JJ
cord-277417-f71jwdzj	349	11	and	and	CC
cord-277417-f71jwdzj	349	12	other	other	JJ
cord-277417-f71jwdzj	349	13	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	349	14	processes	process	NNS
cord-277417-f71jwdzj	350	1	The	the	DT
cord-277417-f71jwdzj	350	2	population	population	NN
cord-277417-f71jwdzj	350	3	genetics	genetics	NN
cord-277417-f71jwdzj	350	4	of	of	IN
cord-277417-f71jwdzj	350	5	dN/	dN/	NNP
cord-277417-f71jwdzj	351	1	dS	dS	NNP
cord-277417-f71jwdzj	351	2	Phylogenetic	phylogenetic	JJ
cord-277417-f71jwdzj	351	3	evidence	evidence	NN
cord-277417-f71jwdzj	351	4	for	for	IN
cord-277417-f71jwdzj	351	5	deleterious	deleterious	JJ
cord-277417-f71jwdzj	351	6	mutation	mutation	NN
cord-277417-f71jwdzj	351	7	load	load	NN
cord-277417-f71jwdzj	351	8	in	in	IN
cord-277417-f71jwdzj	351	9	RNA	RNA	NNP
cord-277417-f71jwdzj	351	10	viruses	virus	NNS
cord-277417-f71jwdzj	351	11	and	and	CC
cord-277417-f71jwdzj	351	12	its	-PRON-	PRP$
cord-277417-f71jwdzj	351	13	contribution	contribution	NN
cord-277417-f71jwdzj	351	14	to	to	IN
cord-277417-f71jwdzj	351	15	viral	viral	JJ
cord-277417-f71jwdzj	351	16	evolution	evolution	NN
cord-277417-f71jwdzj	351	17	The	the	DT
cord-277417-f71jwdzj	351	18	genomic	genomic	JJ
cord-277417-f71jwdzj	351	19	rate	rate	NN
cord-277417-f71jwdzj	351	20	of	of	IN
cord-277417-f71jwdzj	351	21	molecular	molecular	JJ
cord-277417-f71jwdzj	351	22	adaptation	adaptation	NN
cord-277417-f71jwdzj	351	23	of	of	IN
cord-277417-f71jwdzj	351	24	the	the	DT
cord-277417-f71jwdzj	351	25	human	human	JJ
cord-277417-f71jwdzj	351	26	influenza	influenza	NN
cord-277417-f71jwdzj	351	27	A	a	DT
cord-277417-f71jwdzj	351	28	virus	virus	NN
cord-277417-f71jwdzj	351	29	Pathogen	pathogen	NN
cord-277417-f71jwdzj	351	30	population	population	NN
cord-277417-f71jwdzj	351	31	bottlenecks	bottleneck	NNS
cord-277417-f71jwdzj	351	32	and	and	CC
cord-277417-f71jwdzj	351	33	adaptive	adaptive	JJ
cord-277417-f71jwdzj	351	34	landscapes	landscape	NNS
cord-277417-f71jwdzj	351	35	:	:	:
cord-277417-f71jwdzj	351	36	overcoming	overcome	VBG
cord-277417-f71jwdzj	351	37	the	the	DT
cord-277417-f71jwdzj	351	38	barriers	barrier	NNS
cord-277417-f71jwdzj	351	39	to	to	IN
cord-277417-f71jwdzj	351	40	disease	disease	NN
cord-277417-f71jwdzj	351	41	emergence	emergence	NN
cord-277417-f71jwdzj	351	42	Dynamics	dynamic	NNS
cord-277417-f71jwdzj	351	43	of	of	IN
cord-277417-f71jwdzj	351	44	molecular	molecular	JJ
cord-277417-f71jwdzj	351	45	evolution	evolution	NN
cord-277417-f71jwdzj	351	46	in	in	IN
cord-277417-f71jwdzj	351	47	RNA	RNA	NNP
cord-277417-f71jwdzj	351	48	virus	virus	NN
cord-277417-f71jwdzj	351	49	populations	population	NNS
cord-277417-f71jwdzj	351	50	depend	depend	VBP
cord-277417-f71jwdzj	351	51	on	on	IN
cord-277417-f71jwdzj	351	52	sudden	sudden	JJ
cord-277417-f71jwdzj	351	53	versus	versus	IN
cord-277417-f71jwdzj	351	54	gradual	gradual	JJ
cord-277417-f71jwdzj	351	55	environmental	environmental	JJ
cord-277417-f71jwdzj	351	56	change	change	NN
cord-277417-f71jwdzj	351	57	Characterization	characterization	NN
cord-277417-f71jwdzj	351	58	of	of	IN
cord-277417-f71jwdzj	351	59	the	the	DT
cord-277417-f71jwdzj	351	60	1918	1918	CD
cord-277417-f71jwdzj	351	61	influenza	influenza	NN
cord-277417-f71jwdzj	351	62	virus	virus	NN
cord-277417-f71jwdzj	351	63	polymerase	polymerase	NN
cord-277417-f71jwdzj	351	64	genes	gene	NNS
cord-277417-f71jwdzj	351	65	Ancient	ancient	JJ
cord-277417-f71jwdzj	351	66	adaptive	adaptive	JJ
cord-277417-f71jwdzj	351	67	evolution	evolution	NN
cord-277417-f71jwdzj	351	68	of	of	IN
cord-277417-f71jwdzj	351	69	the	the	DT
cord-277417-f71jwdzj	351	70	primate	primate	JJ
cord-277417-f71jwdzj	351	71	antiviral	antiviral	JJ
cord-277417-f71jwdzj	351	72	DNA	dna	NN
cord-277417-f71jwdzj	351	73	-	-	HYPH
cord-277417-f71jwdzj	351	74	editing	editing	NN
cord-277417-f71jwdzj	351	75	enzyme	enzyme	NN
cord-277417-f71jwdzj	352	1	APOBEC3	APOBEC3	NNP
cord-277417-f71jwdzj	352	2	G	G	NNP
cord-277417-f71jwdzj	352	3	Positive	Positive	NNP
cord-277417-f71jwdzj	352	4	selection	selection	NN
cord-277417-f71jwdzj	352	5	of	of	IN
cord-277417-f71jwdzj	352	6	primate	primate	JJ
cord-277417-f71jwdzj	352	7	TRIM5alpha	TRIM5alpha	NNP
cord-277417-f71jwdzj	352	8	identifies	identify	VBZ
cord-277417-f71jwdzj	352	9	a	a	DT
cord-277417-f71jwdzj	352	10	critical	critical	JJ
cord-277417-f71jwdzj	352	11	species	species	NN
cord-277417-f71jwdzj	352	12	-	-	HYPH
cord-277417-f71jwdzj	352	13	specific	specific	JJ
cord-277417-f71jwdzj	352	14	retroviral	retroviral	NN
cord-277417-f71jwdzj	352	15	restriction	restriction	NN
cord-277417-f71jwdzj	352	16	domain	domain	NN
cord-277417-f71jwdzj	352	17	Emerging	emerge	VBG
cord-277417-f71jwdzj	352	18	viruses	virus	NNS
cord-277417-f71jwdzj	352	19	:	:	:
cord-277417-f71jwdzj	353	1	why	why	WRB
cord-277417-f71jwdzj	353	2	they	-PRON-	PRP
cord-277417-f71jwdzj	353	3	are	be	VBP
cord-277417-f71jwdzj	353	4	not	not	RB
cord-277417-f71jwdzj	353	5	jacks	jack	NNS
cord-277417-f71jwdzj	353	6	of	of	IN
cord-277417-f71jwdzj	353	7	all	all	DT
cord-277417-f71jwdzj	353	8	trades	trade	NNS
cord-277417-f71jwdzj	353	9	?	?	.
cord-277417-f71jwdzj	354	1	Human	human	JJ
cord-277417-f71jwdzj	354	2	adaptation	adaptation	NN
cord-277417-f71jwdzj	354	3	of	of	IN
cord-277417-f71jwdzj	354	4	Ebola	Ebola	NNP
cord-277417-f71jwdzj	354	5	virus	virus	NN
cord-277417-f71jwdzj	354	6	during	during	IN
cord-277417-f71jwdzj	354	7	the	the	DT
cord-277417-f71jwdzj	354	8	West	west	JJ
cord-277417-f71jwdzj	354	9	African	african	JJ
cord-277417-f71jwdzj	354	10	outbreak	outbreak	NN
cord-277417-f71jwdzj	355	1	Why	why	WRB
cord-277417-f71jwdzj	355	2	do	do	VBP
cord-277417-f71jwdzj	355	3	RNA	RNA	NNP
cord-277417-f71jwdzj	355	4	viruses	virus	NNS
cord-277417-f71jwdzj	355	5	recombine	recombine	VB
cord-277417-f71jwdzj	355	6	?	?	.
cord-277417-f71jwdzj	356	1	Fluid	fluid	JJ
cord-277417-f71jwdzj	356	2	spatial	spatial	JJ
cord-277417-f71jwdzj	356	3	dynamics	dynamic	NNS
cord-277417-f71jwdzj	356	4	of	of	IN
cord-277417-f71jwdzj	356	5	West	West	NNP
cord-277417-f71jwdzj	356	6	Nile	Nile	NNP
cord-277417-f71jwdzj	356	7	virus	virus	NN
cord-277417-f71jwdzj	356	8	in	in	IN
cord-277417-f71jwdzj	356	9	the	the	DT
cord-277417-f71jwdzj	356	10	USA	USA	NNP
cord-277417-f71jwdzj	356	11	:	:	:
cord-277417-f71jwdzj	357	1	rapid	rapid	JJ
cord-277417-f71jwdzj	357	2	spread	spread	NN
cord-277417-f71jwdzj	357	3	in	in	IN
cord-277417-f71jwdzj	357	4	a	a	DT
cord-277417-f71jwdzj	357	5	permissive	permissive	JJ
cord-277417-f71jwdzj	357	6	host	host	NN
cord-277417-f71jwdzj	357	7	environment	environment	NN
cord-277417-f71jwdzj	357	8	Nile	Nile	NNP
cord-277417-f71jwdzj	357	9	virus	virus	NN
cord-277417-f71jwdzj	357	10	emergence	emergence	NN
cord-277417-f71jwdzj	357	11	and	and	CC
cord-277417-f71jwdzj	357	12	large	large	JJ
cord-277417-f71jwdzj	357	13	-	-	HYPH
cord-277417-f71jwdzj	357	14	scale	scale	NN
cord-277417-f71jwdzj	357	15	declines	decline	NNS
cord-277417-f71jwdzj	357	16	of	of	IN
cord-277417-f71jwdzj	357	17	North	north	JJ
cord-277417-f71jwdzj	357	18	American	american	JJ
cord-277417-f71jwdzj	357	19	bird	bird	NN
cord-277417-f71jwdzj	357	20	populations	population	NNS
cord-277417-f71jwdzj	358	1	Globalization	globalization	NN
cord-277417-f71jwdzj	358	2	,	,	,
cord-277417-f71jwdzj	358	3	land	land	NN
cord-277417-f71jwdzj	358	4	use	use	NN
cord-277417-f71jwdzj	358	5	,	,	,
cord-277417-f71jwdzj	358	6	and	and	CC
cord-277417-f71jwdzj	358	7	the	the	DT
cord-277417-f71jwdzj	358	8	invasion	invasion	NN
cord-277417-f71jwdzj	358	9	of	of	IN
cord-277417-f71jwdzj	358	10	West	West	NNP
cord-277417-f71jwdzj	358	11	Nile	Nile	NNP
cord-277417-f71jwdzj	358	12	virus	virus	NN
cord-277417-f71jwdzj	358	13	H5N1	H5N1	NNP
cord-277417-f71jwdzj	358	14	influenza	influenza	NN
cord-277417-f71jwdzj	358	15	:	:	:
cord-277417-f71jwdzj	358	16	a	a	DT
cord-277417-f71jwdzj	358	17	protean	protean	JJ
cord-277417-f71jwdzj	358	18	pandemic	pandemic	NN
cord-277417-f71jwdzj	358	19	threat	threat	NN
cord-277417-f71jwdzj	358	20	Are	be	VBP
cord-277417-f71jwdzj	358	21	we	-PRON-	PRP
cord-277417-f71jwdzj	358	22	ready	ready	JJ
cord-277417-f71jwdzj	358	23	for	for	IN
cord-277417-f71jwdzj	358	24	pandemic	pandemic	NN
cord-277417-f71jwdzj	358	25	influenza	influenza	NN
cord-277417-f71jwdzj	358	26	?	?	.
cord-277417-f71jwdzj	359	1	Dissemination	dissemination	NN
cord-277417-f71jwdzj	359	2	,	,	,
cord-277417-f71jwdzj	359	3	divergence	divergence	NN
cord-277417-f71jwdzj	359	4	and	and	CC
cord-277417-f71jwdzj	359	5	establishment	establishment	NN
cord-277417-f71jwdzj	359	6	of	of	IN
cord-277417-f71jwdzj	359	7	H7N9	H7N9	NNP
cord-277417-f71jwdzj	359	8	influenza	influenza	NN
cord-277417-f71jwdzj	359	9	viruses	virus	NNS
cord-277417-f71jwdzj	359	10	in	in	IN
cord-277417-f71jwdzj	359	11	China	China	NNP
cord-277417-f71jwdzj	359	12	Genesis	Genesis	NNP
cord-277417-f71jwdzj	359	13	and	and	CC
cord-277417-f71jwdzj	359	14	spread	spread	VBD
cord-277417-f71jwdzj	359	15	of	of	IN
cord-277417-f71jwdzj	359	16	newly	newly	RB
cord-277417-f71jwdzj	359	17	emerged	emerge	VBN
cord-277417-f71jwdzj	359	18	highly	highly	RB
cord-277417-f71jwdzj	359	19	pathogenic	pathogenic	JJ
cord-277417-f71jwdzj	359	20	H7N9	H7N9	NNP
cord-277417-f71jwdzj	359	21	avian	avian	JJ
cord-277417-f71jwdzj	359	22	viruses	virus	NNS
cord-277417-f71jwdzj	359	23	in	in	IN
cord-277417-f71jwdzj	359	24	mainland	mainland	NN
cord-277417-f71jwdzj	359	25	China	China	NNP
cord-277417-f71jwdzj	359	26	Emergence	Emergence	NNP
cord-277417-f71jwdzj	359	27	and	and	CC
cord-277417-f71jwdzj	359	28	adaptation	adaptation	NN
cord-277417-f71jwdzj	359	29	of	of	IN
cord-277417-f71jwdzj	359	30	a	a	DT
cord-277417-f71jwdzj	359	31	novel	novel	NN
cord-277417-f71jwdzj	359	32	highly	highly	RB
cord-277417-f71jwdzj	359	33	pathogenic	pathogenic	JJ
cord-277417-f71jwdzj	359	34	H7N9	H7N9	NNP
cord-277417-f71jwdzj	359	35	influenza	influenza	NN
cord-277417-f71jwdzj	359	36	virus	virus	NN
cord-277417-f71jwdzj	359	37	in	in	IN
cord-277417-f71jwdzj	359	38	birds	bird	NNS
cord-277417-f71jwdzj	359	39	and	and	CC
cord-277417-f71jwdzj	359	40	humans	human	NNS
cord-277417-f71jwdzj	359	41	from	from	IN
cord-277417-f71jwdzj	359	42	a	a	DT
cord-277417-f71jwdzj	359	43	2013	2013	CD
cord-277417-f71jwdzj	359	44	human	human	NN
cord-277417-f71jwdzj	359	45	-	-	HYPH
cord-277417-f71jwdzj	359	46	infecting	infect	VBG
cord-277417-f71jwdzj	359	47	low	low	JJ
cord-277417-f71jwdzj	359	48	pathogenic	pathogenic	JJ
cord-277417-f71jwdzj	359	49	ancestor	ancestor	NN
cord-277417-f71jwdzj	359	50	Viral	viral	JJ
cord-277417-f71jwdzj	359	51	factors	factor	NNS
cord-277417-f71jwdzj	359	52	in	in	IN
cord-277417-f71jwdzj	359	53	influenza	influenza	NN
cord-277417-f71jwdzj	359	54	pandemic	pandemic	JJ
cord-277417-f71jwdzj	359	55	risk	risk	NN
cord-277417-f71jwdzj	359	56	assessment	assessment	NN
cord-277417-f71jwdzj	359	57	Influenza	Influenza	NNP
cord-277417-f71jwdzj	359	58	type	type	NN
cord-277417-f71jwdzj	359	59	A	a	NN
cord-277417-f71jwdzj	359	60	in	in	IN
cord-277417-f71jwdzj	359	61	humans	human	NNS
cord-277417-f71jwdzj	359	62	,	,	,
cord-277417-f71jwdzj	359	63	mammals	mammal	NNS
cord-277417-f71jwdzj	359	64	and	and	CC
cord-277417-f71jwdzj	359	65	birds	bird	NNS
cord-277417-f71jwdzj	359	66	:	:	:
cord-277417-f71jwdzj	359	67	determinants	determinant	NNS
cord-277417-f71jwdzj	359	68	of	of	IN
cord-277417-f71jwdzj	359	69	virus	virus	NN
cord-277417-f71jwdzj	359	70	virulence	virulence	NN
cord-277417-f71jwdzj	359	71	,	,	,
cord-277417-f71jwdzj	359	72	host	host	NN
cord-277417-f71jwdzj	359	73	-	-	HYPH
cord-277417-f71jwdzj	359	74	range	range	NN
cord-277417-f71jwdzj	359	75	and	and	CC
cord-277417-f71jwdzj	359	76	interspecies	interspecie	NNS
cord-277417-f71jwdzj	359	77	transmission	transmission	NN
cord-277417-f71jwdzj	359	78	Influenza	influenza	NN
cord-277417-f71jwdzj	359	79	:	:	:
cord-277417-f71jwdzj	359	80	lessons	lesson	NNS
cord-277417-f71jwdzj	359	81	from	from	IN
cord-277417-f71jwdzj	359	82	past	past	JJ
cord-277417-f71jwdzj	359	83	pandemics	pandemic	NNS
cord-277417-f71jwdzj	359	84	,	,	,
cord-277417-f71jwdzj	359	85	warnings	warning	NNS
cord-277417-f71jwdzj	359	86	from	from	IN
cord-277417-f71jwdzj	359	87	current	current	JJ
cord-277417-f71jwdzj	359	88	incidents	incident	NNS
cord-277417-f71jwdzj	359	89	Emergence	Emergence	NNP
cord-277417-f71jwdzj	359	90	of	of	IN
cord-277417-f71jwdzj	359	91	a	a	DT
cord-277417-f71jwdzj	359	92	highly	highly	RB
cord-277417-f71jwdzj	359	93	pathogenic	pathogenic	JJ
cord-277417-f71jwdzj	359	94	avian	avian	JJ
cord-277417-f71jwdzj	359	95	influenza	influenza	NN
cord-277417-f71jwdzj	359	96	virus	virus	NN
cord-277417-f71jwdzj	359	97	from	from	IN
cord-277417-f71jwdzj	359	98	a	a	DT
cord-277417-f71jwdzj	359	99	low	low	JJ
cord-277417-f71jwdzj	359	100	pathogenic	pathogenic	JJ
cord-277417-f71jwdzj	359	101	progenitor	progenitor	NN
cord-277417-f71jwdzj	360	1	The	the	DT
cord-277417-f71jwdzj	360	2	potential	potential	NN
cord-277417-f71jwdzj	360	3	for	for	IN
cord-277417-f71jwdzj	360	4	respiratory	respiratory	JJ
cord-277417-f71jwdzj	360	5	droplet	droplet	NN
cord-277417-f71jwdzj	360	6	-	-	HYPH
cord-277417-f71jwdzj	360	7	transmissible	transmissible	JJ
cord-277417-f71jwdzj	360	8	A	A	NNP
cord-277417-f71jwdzj	360	9	/	/	SYM
cord-277417-f71jwdzj	360	10	H5N1	H5N1	NNP
cord-277417-f71jwdzj	360	11	influenza	influenza	NN
cord-277417-f71jwdzj	360	12	virus	virus	NN
cord-277417-f71jwdzj	360	13	to	to	TO
cord-277417-f71jwdzj	360	14	evolve	evolve	VB
cord-277417-f71jwdzj	360	15	in	in	IN
cord-277417-f71jwdzj	360	16	a	a	DT
cord-277417-f71jwdzj	360	17	mammalian	mammalian	JJ
cord-277417-f71jwdzj	360	18	host	host	NN
cord-277417-f71jwdzj	360	19	Molecular	molecular	JJ
cord-277417-f71jwdzj	360	20	basis	basis	NN
cord-277417-f71jwdzj	360	21	for	for	IN
cord-277417-f71jwdzj	360	22	high	high	JJ
cord-277417-f71jwdzj	360	23	virulence	virulence	NN
cord-277417-f71jwdzj	360	24	of	of	IN
cord-277417-f71jwdzj	360	25	Hong	Hong	NNP
cord-277417-f71jwdzj	360	26	Kong	Kong	NNP
cord-277417-f71jwdzj	360	27	H5N1	H5N1	NNP
cord-277417-f71jwdzj	361	1	influenza	influenza	NN
cord-277417-f71jwdzj	361	2	A	a	DT
cord-277417-f71jwdzj	361	3	viruses	virus	NNS
cord-277417-f71jwdzj	362	1	Enhanced	enhanced	JJ
cord-277417-f71jwdzj	362	2	virulence	virulence	NN
cord-277417-f71jwdzj	362	3	of	of	IN
cord-277417-f71jwdzj	362	4	clade	clade	NN
cord-277417-f71jwdzj	362	5	2.3.2.1	2.3.2.1	CD
cord-277417-f71jwdzj	362	6	highly	highly	RB
cord-277417-f71jwdzj	362	7	pathogenic	pathogenic	JJ
cord-277417-f71jwdzj	362	8	avian	avian	JJ
cord-277417-f71jwdzj	362	9	influenza	influenza	NN
cord-277417-f71jwdzj	362	10	A	a	DT
cord-277417-f71jwdzj	362	11	H5N1	H5N1	NNP
cord-277417-f71jwdzj	362	12	viruses	virus	NNS
cord-277417-f71jwdzj	362	13	in	in	IN
cord-277417-f71jwdzj	363	1	ferrets	ferret	NNS
cord-277417-f71jwdzj	363	2	NS1	ns1	VBP
cord-277417-f71jwdzj	363	3	protein	protein	NN
cord-277417-f71jwdzj	363	4	amino	amino	NN
cord-277417-f71jwdzj	363	5	acid	acid	NN
cord-277417-f71jwdzj	363	6	changes	change	NNS
cord-277417-f71jwdzj	364	1	D189N	D189N	NNP
cord-277417-f71jwdzj	364	2	and	and	CC
cord-277417-f71jwdzj	364	3	V194I	V194I	NNS
cord-277417-f71jwdzj	364	4	affect	affect	VBP
cord-277417-f71jwdzj	364	5	interferon	interferon	NN
cord-277417-f71jwdzj	364	6	responses	response	NNS
cord-277417-f71jwdzj	364	7	,	,	,
cord-277417-f71jwdzj	364	8	thermosensitivity	thermosensitivity	NN
cord-277417-f71jwdzj	364	9	,	,	,
cord-277417-f71jwdzj	364	10	and	and	CC
cord-277417-f71jwdzj	364	11	virulence	virulence	NN
cord-277417-f71jwdzj	364	12	of	of	IN
cord-277417-f71jwdzj	364	13	circulating	circulate	VBG
cord-277417-f71jwdzj	364	14	H3N2	H3N2	NNP
cord-277417-f71jwdzj	364	15	human	human	JJ
cord-277417-f71jwdzj	364	16	influenza	influenza	NN
cord-277417-f71jwdzj	364	17	A	a	DT
cord-277417-f71jwdzj	364	18	viruses	virus	NNS
cord-277417-f71jwdzj	365	1	A	a	DT
cord-277417-f71jwdzj	365	2	new	new	JJ
cord-277417-f71jwdzj	365	3	influenza	influenza	NN
cord-277417-f71jwdzj	365	4	virus	virus	NN
cord-277417-f71jwdzj	365	5	virulence	virulence	NN
cord-277417-f71jwdzj	365	6	determinant	determinant	NN
cord-277417-f71jwdzj	365	7	:	:	:
cord-277417-f71jwdzj	366	1	the	the	DT
cord-277417-f71jwdzj	366	2	NS1	NS1	NNP
cord-277417-f71jwdzj	366	3	protein	protein	NN
cord-277417-f71jwdzj	366	4	four	four	CD
cord-277417-f71jwdzj	366	5	C	c	NN
cord-277417-f71jwdzj	366	6	-	-	HYPH
cord-277417-f71jwdzj	366	7	terminal	terminal	NN
cord-277417-f71jwdzj	366	8	residues	residue	NNS
cord-277417-f71jwdzj	366	9	modulate	modulate	VBP
cord-277417-f71jwdzj	366	10	pathogenicity	pathogenicity	NN
cord-277417-f71jwdzj	367	1	This	this	DT
cord-277417-f71jwdzj	367	2	paper	paper	NN
cord-277417-f71jwdzj	367	3	presents	present	VBZ
cord-277417-f71jwdzj	367	4	a	a	DT
cord-277417-f71jwdzj	367	5	comprehensive	comprehensive	JJ
cord-277417-f71jwdzj	367	6	study	study	NN
cord-277417-f71jwdzj	367	7	of	of	IN
cord-277417-f71jwdzj	367	8	the	the	DT
cord-277417-f71jwdzj	367	9	virulence	virulence	NN
cord-277417-f71jwdzj	367	10	of	of	IN
cord-277417-f71jwdzj	367	11	the	the	DT
cord-277417-f71jwdzj	367	12	1918	1918	CD
cord-277417-f71jwdzj	367	13	influenza	influenza	NN
cord-277417-f71jwdzj	367	14	virus	virus	NN
cord-277417-f71jwdzj	367	15	in	in	IN
cord-277417-f71jwdzj	367	16	a	a	DT
cord-277417-f71jwdzj	367	17	mouse	mouse	NN
cord-277417-f71jwdzj	367	18	model	model	NN
cord-277417-f71jwdzj	367	19	,	,	,
cord-277417-f71jwdzj	367	20	revealing	reveal	VBG
cord-277417-f71jwdzj	367	21	the	the	DT
cord-277417-f71jwdzj	367	22	importance	importance	NN
cord-277417-f71jwdzj	367	23	of	of	IN
cord-277417-f71jwdzj	367	24	virus	virus	NN
cord-277417-f71jwdzj	367	25	-	-	HYPH
cord-277417-f71jwdzj	367	26	host	host	NN
cord-277417-f71jwdzj	367	27	interactions	interaction	NNS
cord-277417-f71jwdzj	367	28	involving	involve	VBG
cord-277417-f71jwdzj	367	29	a	a	DT
cord-277417-f71jwdzj	367	30	wide	wide	JJ
cord-277417-f71jwdzj	367	31	set	set	NN
cord-277417-f71jwdzj	367	32	of	of	IN
cord-277417-f71jwdzj	367	33	interacting	interact	VBG
cord-277417-f71jwdzj	367	34	virus	virus	NN
cord-277417-f71jwdzj	367	35	genes	gene	NNS
cord-277417-f71jwdzj	368	1	A	a	DT
cord-277417-f71jwdzj	368	2	single	single	JJ
cord-277417-f71jwdzj	368	3	amino	amino	NN
cord-277417-f71jwdzj	368	4	acid	acid	NN
cord-277417-f71jwdzj	368	5	in	in	IN
cord-277417-f71jwdzj	368	6	the	the	DT
cord-277417-f71jwdzj	368	7	polymerase	polymerase	NN
cord-277417-f71jwdzj	368	8	acidic	acidic	JJ
cord-277417-f71jwdzj	368	9	protein	protein	NN
cord-277417-f71jwdzj	368	10	determines	determine	VBZ
cord-277417-f71jwdzj	368	11	the	the	DT
cord-277417-f71jwdzj	368	12	pathogenicity	pathogenicity	NN
cord-277417-f71jwdzj	368	13	of	of	IN
cord-277417-f71jwdzj	368	14	influenza	influenza	NN
cord-277417-f71jwdzj	368	15	B	b	NN
cord-277417-f71jwdzj	368	16	viruses	virus	NNS
cord-277417-f71jwdzj	368	17	Biological	biological	JJ
cord-277417-f71jwdzj	368	18	control	control	NN
cord-277417-f71jwdzj	368	19	as	as	IN
cord-277417-f71jwdzj	368	20	exemplified	exemplify	VBN
cord-277417-f71jwdzj	368	21	by	by	IN
cord-277417-f71jwdzj	368	22	smallpox	smallpox	NN
cord-277417-f71jwdzj	368	23	eradication	eradication	NN
cord-277417-f71jwdzj	368	24	and	and	CC
cord-277417-f71jwdzj	368	25	myxomatosis	myxomatosis	NN
cord-277417-f71jwdzj	368	26	A	a	DT
cord-277417-f71jwdzj	368	27	comparison	comparison	NN
cord-277417-f71jwdzj	368	28	of	of	IN
cord-277417-f71jwdzj	368	29	the	the	DT
cord-277417-f71jwdzj	368	30	virulence	virulence	NN
cord-277417-f71jwdzj	368	31	for	for	IN
cord-277417-f71jwdzj	368	32	European	european	JJ
cord-277417-f71jwdzj	368	33	rabbits	rabbit	NNS
cord-277417-f71jwdzj	368	34	(	(	-LRB-
cord-277417-f71jwdzj	368	35	Oryctolagus	Oryctolagus	NNP
cord-277417-f71jwdzj	368	36	cuniculus	cuniculus	NN
cord-277417-f71jwdzj	368	37	)	)	-RRB-
cord-277417-f71jwdzj	368	38	of	of	IN
cord-277417-f71jwdzj	368	39	strains	strain	NNS
cord-277417-f71jwdzj	368	40	of	of	IN
cord-277417-f71jwdzj	368	41	myxoma	myxoma	NNP
cord-277417-f71jwdzj	368	42	virus	virus	NN
cord-277417-f71jwdzj	368	43	recovered	recover	VBN
cord-277417-f71jwdzj	368	44	in	in	IN
cord-277417-f71jwdzj	368	45	the	the	DT
cord-277417-f71jwdzj	368	46	field	field	NN
cord-277417-f71jwdzj	368	47	in	in	IN
cord-277417-f71jwdzj	368	48	Australia	Australia	NNP
cord-277417-f71jwdzj	368	49	,	,	,
cord-277417-f71jwdzj	368	50	Europe	Europe	NNP
cord-277417-f71jwdzj	368	51	and	and	CC
cord-277417-f71jwdzj	368	52	America	America	NNP
cord-277417-f71jwdzj	368	53	Evolutionary	Evolutionary	NNP
cord-277417-f71jwdzj	368	54	history	history	NN
cord-277417-f71jwdzj	368	55	and	and	CC
cord-277417-f71jwdzj	368	56	attenuation	attenuation	NN
cord-277417-f71jwdzj	368	57	of	of	IN
cord-277417-f71jwdzj	368	58	myxoma	myxoma	NN
cord-277417-f71jwdzj	368	59	virus	virus	NN
cord-277417-f71jwdzj	368	60	on	on	IN
cord-277417-f71jwdzj	368	61	two	two	CD
cord-277417-f71jwdzj	368	62	continents	continent	NNS
cord-277417-f71jwdzj	368	63	This	this	DT
cord-277417-f71jwdzj	368	64	article	article	NN
cord-277417-f71jwdzj	368	65	presents	present	VBZ
cord-277417-f71jwdzj	368	66	the	the	DT
cord-277417-f71jwdzj	368	67	first	first	JJ
cord-277417-f71jwdzj	368	68	large	large	JJ
cord-277417-f71jwdzj	368	69	-	-	HYPH
cord-277417-f71jwdzj	368	70	scale	scale	NN
cord-277417-f71jwdzj	368	71	phylogenomic	phylogenomic	JJ
cord-277417-f71jwdzj	368	72	analysis	analysis	NN
cord-277417-f71jwdzj	368	73	of	of	IN
cord-277417-f71jwdzj	368	74	MYXV	MYXV	NNP
cord-277417-f71jwdzj	368	75	and	and	CC
cord-277417-f71jwdzj	368	76	shows	show	VBZ
cord-277417-f71jwdzj	368	77	that	that	IN
cord-277417-f71jwdzj	368	78	,	,	,
cord-277417-f71jwdzj	368	79	despite	despite	IN
cord-277417-f71jwdzj	368	80	parallel	parallel	JJ
cord-277417-f71jwdzj	368	81	evolution	evolution	NN
cord-277417-f71jwdzj	368	82	at	at	IN
cord-277417-f71jwdzj	368	83	the	the	DT
cord-277417-f71jwdzj	368	84	phenotypic	phenotypic	NN
cord-277417-f71jwdzj	368	85	(	(	-LRB-
cord-277417-f71jwdzj	368	86	that	that	RB
cord-277417-f71jwdzj	368	87	is	is	RB
cord-277417-f71jwdzj	368	88	,	,	,
cord-277417-f71jwdzj	368	89	virulence	virulence	NN
cord-277417-f71jwdzj	368	90	grade	grade	NN
cord-277417-f71jwdzj	368	91	)	)	-RRB-
cord-277417-f71jwdzj	368	92	level	level	NN
cord-277417-f71jwdzj	368	93	,	,	,
cord-277417-f71jwdzj	368	94	different	different	JJ
cord-277417-f71jwdzj	368	95	virus	virus	NN
cord-277417-f71jwdzj	368	96	mutations	mutation	NNS
cord-277417-f71jwdzj	368	97	were	be	VBD
cord-277417-f71jwdzj	368	98	responsible	responsible	JJ
cord-277417-f71jwdzj	368	99	for	for	IN
cord-277417-f71jwdzj	368	100	evolution	evolution	NN
cord-277417-f71jwdzj	368	101	Genome	Genome	NNP
cord-277417-f71jwdzj	368	102	scale	scale	NN
cord-277417-f71jwdzj	368	103	evolution	evolution	NN
cord-277417-f71jwdzj	368	104	of	of	IN
cord-277417-f71jwdzj	368	105	myxoma	myxoma	NN
cord-277417-f71jwdzj	368	106	virus	virus	NN
cord-277417-f71jwdzj	368	107	(	(	-LRB-
cord-277417-f71jwdzj	368	108	MYXV	MYXV	NNP
cord-277417-f71jwdzj	368	109	)	)	-RRB-
cord-277417-f71jwdzj	369	1	reveals	reveal	VBZ
cord-277417-f71jwdzj	369	2	host	host	NN
cord-277417-f71jwdzj	369	3	-	-	HYPH
cord-277417-f71jwdzj	369	4	pathogen	pathogen	NN
cord-277417-f71jwdzj	369	5	adaptation	adaptation	NN
cord-277417-f71jwdzj	369	6	and	and	CC
cord-277417-f71jwdzj	369	7	rapid	rapid	JJ
cord-277417-f71jwdzj	369	8	geographic	geographic	JJ
cord-277417-f71jwdzj	369	9	spread	spread	NN
cord-277417-f71jwdzj	369	10	Mechanisms	Mechanisms	NNPS
cord-277417-f71jwdzj	369	11	of	of	IN
cord-277417-f71jwdzj	369	12	genetic	genetic	JJ
cord-277417-f71jwdzj	369	13	robustness	robustness	NN
cord-277417-f71jwdzj	369	14	in	in	IN
cord-277417-f71jwdzj	369	15	RNA	RNA	NNP
cord-277417-f71jwdzj	369	16	viruses	virus	NNS
cord-277417-f71jwdzj	370	1	Imperfect	imperfect	JJ
cord-277417-f71jwdzj	370	2	vaccines	vaccine	NNS
cord-277417-f71jwdzj	370	3	and	and	CC
cord-277417-f71jwdzj	370	4	the	the	DT
cord-277417-f71jwdzj	370	5	evolution	evolution	NN
cord-277417-f71jwdzj	370	6	of	of	IN
cord-277417-f71jwdzj	370	7	pathogen	pathogen	NN
cord-277417-f71jwdzj	370	8	virulence	virulence	NN
cord-277417-f71jwdzj	370	9	Imperfect	imperfect	JJ
cord-277417-f71jwdzj	370	10	vaccines	vaccine	NNS
cord-277417-f71jwdzj	370	11	and	and	CC
cord-277417-f71jwdzj	370	12	imperfect	imperfect	JJ
cord-277417-f71jwdzj	370	13	models	model	NNS
cord-277417-f71jwdzj	371	1	This	this	DT
cord-277417-f71jwdzj	371	2	paper	paper	NN
cord-277417-f71jwdzj	371	3	presents	present	VBZ
cord-277417-f71jwdzj	371	4	a	a	DT
cord-277417-f71jwdzj	371	5	clear	clear	JJ
cord-277417-f71jwdzj	371	6	demonstration	demonstration	NN
cord-277417-f71jwdzj	371	7	that	that	WDT
cord-277417-f71jwdzj	371	8	imperfect	imperfect	JJ
cord-277417-f71jwdzj	371	9	vaccination	vaccination	NN
cord-277417-f71jwdzj	371	10	was	be	VBD
cord-277417-f71jwdzj	371	11	responsible	responsible	JJ
cord-277417-f71jwdzj	371	12	for	for	IN
cord-277417-f71jwdzj	371	13	increased	increase	VBN
cord-277417-f71jwdzj	371	14	virulence	virulence	NN
cord-277417-f71jwdzj	371	15	in	in	IN
cord-277417-f71jwdzj	371	16	the	the	DT
cord-277417-f71jwdzj	371	17	case	case	NN
cord-277417-f71jwdzj	371	18	of	of	IN
cord-277417-f71jwdzj	371	19	the	the	DT
cord-277417-f71jwdzj	371	20	MDV	MDV	NNP
cord-277417-f71jwdzj	371	21	of	of	IN
cord-277417-f71jwdzj	371	22	chickens	chicken	NNS
cord-277417-f71jwdzj	371	23	and	and	CC
cord-277417-f71jwdzj	371	24	considers	consider	VBZ
cord-277417-f71jwdzj	371	25	the	the	DT
cord-277417-f71jwdzj	371	26	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	371	27	implications	implication	NNS
cord-277417-f71jwdzj	371	28	of	of	IN
cord-277417-f71jwdzj	371	29	imperfect	imperfect	JJ
cord-277417-f71jwdzj	371	30	vaccination	vaccination	NN
cord-277417-f71jwdzj	371	31	in	in	IN
cord-277417-f71jwdzj	371	32	general	general	JJ
cord-277417-f71jwdzj	371	33	vLIP	vLIP	NNP
cord-277417-f71jwdzj	371	34	,	,	,
cord-277417-f71jwdzj	371	35	a	a	DT
cord-277417-f71jwdzj	371	36	viral	viral	JJ
cord-277417-f71jwdzj	371	37	lipase	lipase	NN
cord-277417-f71jwdzj	371	38	homologue	homologue	NN
cord-277417-f71jwdzj	371	39	,	,	,
cord-277417-f71jwdzj	371	40	is	be	VBZ
cord-277417-f71jwdzj	371	41	a	a	DT
cord-277417-f71jwdzj	371	42	virulence	virulence	NN
cord-277417-f71jwdzj	371	43	factor	factor	NN
cord-277417-f71jwdzj	371	44	of	of	IN
cord-277417-f71jwdzj	371	45	Marek	Marek	NNP
cord-277417-f71jwdzj	371	46	's	's	POS
cord-277417-f71jwdzj	371	47	disease	disease	NN
cord-277417-f71jwdzj	371	48	virus	virus	NN
cord-277417-f71jwdzj	372	1	A	a	DT
cord-277417-f71jwdzj	372	2	phylogenomic	phylogenomic	JJ
cord-277417-f71jwdzj	372	3	analysis	analysis	NN
cord-277417-f71jwdzj	372	4	of	of	IN
cord-277417-f71jwdzj	372	5	Marek	Marek	NNP
cord-277417-f71jwdzj	372	6	's	's	POS
cord-277417-f71jwdzj	372	7	disease	disease	NN
cord-277417-f71jwdzj	372	8	virus	virus	NN
cord-277417-f71jwdzj	372	9	reveals	reveal	VBZ
cord-277417-f71jwdzj	372	10	independent	independent	JJ
cord-277417-f71jwdzj	372	11	paths	path	NNS
cord-277417-f71jwdzj	372	12	to	to	IN
cord-277417-f71jwdzj	372	13	virulence	virulence	NN
cord-277417-f71jwdzj	372	14	in	in	IN
cord-277417-f71jwdzj	372	15	Eurasia	Eurasia	NNP
cord-277417-f71jwdzj	372	16	and	and	CC
cord-277417-f71jwdzj	372	17	North	North	NNP
cord-277417-f71jwdzj	372	18	America	America	NNP
cord-277417-f71jwdzj	372	19	Immunity	Immunity	NNP
cord-277417-f71jwdzj	372	20	promotes	promote	VBZ
cord-277417-f71jwdzj	372	21	virulence	virulence	NN
cord-277417-f71jwdzj	372	22	evolution	evolution	NN
cord-277417-f71jwdzj	372	23	in	in	IN
cord-277417-f71jwdzj	372	24	a	a	DT
cord-277417-f71jwdzj	372	25	malaria	malaria	NN
cord-277417-f71jwdzj	372	26	model	model	NN
cord-277417-f71jwdzj	372	27	Has	have	VBZ
cord-277417-f71jwdzj	372	28	the	the	DT
cord-277417-f71jwdzj	372	29	rate	rate	NN
cord-277417-f71jwdzj	372	30	of	of	IN
cord-277417-f71jwdzj	372	31	progression	progression	NN
cord-277417-f71jwdzj	372	32	to	to	IN
cord-277417-f71jwdzj	372	33	AIDS	AIDS	NNP
cord-277417-f71jwdzj	372	34	changed	change	VBN
cord-277417-f71jwdzj	372	35	in	in	IN
cord-277417-f71jwdzj	372	36	recent	recent	JJ
cord-277417-f71jwdzj	372	37	years	year	NNS
cord-277417-f71jwdzj	372	38	?	?	.
cord-277417-f71jwdzj	373	1	Virulence	virulence	NN
cord-277417-f71jwdzj	373	2	and	and	CC
cord-277417-f71jwdzj	373	3	pathogenesis	pathogenesis	NN
cord-277417-f71jwdzj	373	4	of	of	IN
cord-277417-f71jwdzj	373	5	HIV-1	HIV-1	NNP
cord-277417-f71jwdzj	373	6	infection	infection	NN
cord-277417-f71jwdzj	373	7	:	:	:
cord-277417-f71jwdzj	373	8	an	an	DT
cord-277417-f71jwdzj	373	9	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	373	10	perspective	perspective	NN
cord-277417-f71jwdzj	374	1	This	this	DT
cord-277417-f71jwdzj	374	2	key	key	JJ
cord-277417-f71jwdzj	374	3	study	study	NN
cord-277417-f71jwdzj	374	4	of	of	IN
cord-277417-f71jwdzj	374	5	the	the	DT
cord-277417-f71jwdzj	374	6	evolution	evolution	NN
cord-277417-f71jwdzj	374	7	of	of	IN
cord-277417-f71jwdzj	374	8	HIV	HIV	NNP
cord-277417-f71jwdzj	374	9	virulence	virulence	NN
cord-277417-f71jwdzj	374	10	focuses	focus	VBZ
cord-277417-f71jwdzj	374	11	on	on	IN
cord-277417-f71jwdzj	374	12	the	the	DT
cord-277417-f71jwdzj	374	13	factors	factor	NNS
cord-277417-f71jwdzj	374	14	that	that	WDT
cord-277417-f71jwdzj	374	15	determine	determine	VBP
cord-277417-f71jwdzj	374	16	the	the	DT
cord-277417-f71jwdzj	374	17	SPVL	SPVL	NNP
cord-277417-f71jwdzj	374	18	and	and	CC
cord-277417-f71jwdzj	374	19	shows	show	VBZ
cord-277417-f71jwdzj	374	20	the	the	DT
cord-277417-f71jwdzj	374	21	importance	importance	NN
cord-277417-f71jwdzj	374	22	of	of	IN
cord-277417-f71jwdzj	374	23	virus	virus	NN
cord-277417-f71jwdzj	374	24	genetic	genetic	JJ
cord-277417-f71jwdzj	374	25	traits	trait	NNS
cord-277417-f71jwdzj	374	26	in	in	IN
cord-277417-f71jwdzj	374	27	shaping	shape	VBG
cord-277417-f71jwdzj	374	28	SPVL	SPVL	NNS
cord-277417-f71jwdzj	374	29	and	and	CC
cord-277417-f71jwdzj	374	30	hence	hence	RB
cord-277417-f71jwdzj	374	31	disease	disease	NN
cord-277417-f71jwdzj	374	32	severity	severity	NN
cord-277417-f71jwdzj	375	1	Temporal	temporal	JJ
cord-277417-f71jwdzj	375	2	trends	trend	NNS
cord-277417-f71jwdzj	375	3	of	of	IN
cord-277417-f71jwdzj	375	4	initial	initial	JJ
cord-277417-f71jwdzj	375	5	CD4	CD4	NNP
cord-277417-f71jwdzj	375	6	cell	cell	NN
cord-277417-f71jwdzj	375	7	counts	count	VBZ
cord-277417-f71jwdzj	375	8	following	follow	VBG
cord-277417-f71jwdzj	375	9	human	human	JJ
cord-277417-f71jwdzj	375	10	immunodeficiency	immunodeficiency	NN
cord-277417-f71jwdzj	375	11	virus	virus	NN
cord-277417-f71jwdzj	375	12	seroconversion	seroconversion	NN
cord-277417-f71jwdzj	375	13	in	in	IN
cord-277417-f71jwdzj	375	14	Italy	Italy	NNP
cord-277417-f71jwdzj	375	15	,	,	,
cord-277417-f71jwdzj	375	16	1985	1985	CD
cord-277417-f71jwdzj	375	17	-	-	SYM
cord-277417-f71jwdzj	375	18	1992	1992	CD
cord-277417-f71jwdzj	375	19	.	.	.
cord-277417-f71jwdzj	376	1	The	the	DT
cord-277417-f71jwdzj	376	2	human	human	JJ
cord-277417-f71jwdzj	376	3	immunodeficiency	immunodeficiency	NN
cord-277417-f71jwdzj	376	4	virus	virus	NN
cord-277417-f71jwdzj	376	5	Italian	italian	JJ
cord-277417-f71jwdzj	376	6	seroconversion	seroconversion	NN
cord-277417-f71jwdzj	376	7	study	study	NN
cord-277417-f71jwdzj	376	8	Is	be	VBZ
cord-277417-f71jwdzj	376	9	the	the	DT
cord-277417-f71jwdzj	376	10	virulence	virulence	NN
cord-277417-f71jwdzj	376	11	of	of	IN
cord-277417-f71jwdzj	376	12	HIV	HIV	NNP
cord-277417-f71jwdzj	376	13	changing	change	VBG
cord-277417-f71jwdzj	376	14	?	?	.
cord-277417-f71jwdzj	377	1	A	a	DT
cord-277417-f71jwdzj	377	2	meta	meta	JJ
cord-277417-f71jwdzj	377	3	-	-	HYPH
cord-277417-f71jwdzj	377	4	analysis	analysis	NN
cord-277417-f71jwdzj	377	5	of	of	IN
cord-277417-f71jwdzj	377	6	trends	trend	NNS
cord-277417-f71jwdzj	377	7	in	in	IN
cord-277417-f71jwdzj	377	8	prognostic	prognostic	JJ
cord-277417-f71jwdzj	377	9	markers	marker	NNS
cord-277417-f71jwdzj	377	10	of	of	IN
cord-277417-f71jwdzj	377	11	HIV	HIV	NNP
cord-277417-f71jwdzj	377	12	disease	disease	NN
cord-277417-f71jwdzj	377	13	progression	progression	NN
cord-277417-f71jwdzj	377	14	and	and	CC
cord-277417-f71jwdzj	377	15	transmission	transmission	NNP
cord-277417-f71jwdzj	377	16	Association	Association	NNP
cord-277417-f71jwdzj	377	17	between	between	IN
cord-277417-f71jwdzj	377	18	the	the	DT
cord-277417-f71jwdzj	377	19	rate	rate	NN
cord-277417-f71jwdzj	377	20	of	of	IN
cord-277417-f71jwdzj	377	21	CD4	CD4	NNP
cord-277417-f71jwdzj	377	22	+	+	CC
cord-277417-f71jwdzj	377	23	T	T	NNP
cord-277417-f71jwdzj	377	24	cell	cell	NN
cord-277417-f71jwdzj	377	25	decrease	decrease	NN
cord-277417-f71jwdzj	377	26	and	and	CC
cord-277417-f71jwdzj	377	27	the	the	DT
cord-277417-f71jwdzj	377	28	year	year	NN
cord-277417-f71jwdzj	377	29	of	of	IN
cord-277417-f71jwdzj	377	30	human	human	NNP
cord-277417-f71jwdzj	377	31	immunodeficeny	immunodeficeny	NNP
cord-277417-f71jwdzj	377	32	virus	virus	NN
cord-277417-f71jwdzj	377	33	(	(	-LRB-
cord-277417-f71jwdzj	377	34	HIV	HIV	NNP
cord-277417-f71jwdzj	377	35	)	)	-RRB-
cord-277417-f71jwdzj	377	36	type	type	NN
cord-277417-f71jwdzj	377	37	1	1	CD
cord-277417-f71jwdzj	377	38	seroconversion	seroconversion	NN
cord-277417-f71jwdzj	377	39	among	among	IN
cord-277417-f71jwdzj	377	40	persons	person	NNS
cord-277417-f71jwdzj	377	41	enrolled	enrol	VBN
cord-277417-f71jwdzj	377	42	in	in	IN
cord-277417-f71jwdzj	377	43	the	the	DT
cord-277417-f71jwdzj	377	44	Swiss	swiss	JJ
cord-277417-f71jwdzj	377	45	HIV	HIV	NNP
cord-277417-f71jwdzj	377	46	cohort	cohort	NN
cord-277417-f71jwdzj	377	47	study	study	NN
cord-277417-f71jwdzj	377	48	Is	be	VBZ
cord-277417-f71jwdzj	377	49	HIV-1	HIV-1	NNP
cord-277417-f71jwdzj	377	50	evolving	evolve	VBG
cord-277417-f71jwdzj	377	51	to	to	IN
cord-277417-f71jwdzj	377	52	a	a	DT
cord-277417-f71jwdzj	377	53	less	less	RBR
cord-277417-f71jwdzj	377	54	virulent	virulent	JJ
cord-277417-f71jwdzj	377	55	form	form	NN
cord-277417-f71jwdzj	377	56	in	in	IN
cord-277417-f71jwdzj	377	57	humans	human	NNS
cord-277417-f71jwdzj	377	58	?	?	.
cord-277417-f71jwdzj	378	1	Replicative	replicative	JJ
cord-277417-f71jwdzj	378	2	fitness	fitness	NN
cord-277417-f71jwdzj	378	3	of	of	IN
cord-277417-f71jwdzj	378	4	transmitted	transmit	VBN
cord-277417-f71jwdzj	378	5	HIV-1	HIV-1	NNP
cord-277417-f71jwdzj	378	6	drives	drive	VBZ
cord-277417-f71jwdzj	378	7	acute	acute	JJ
cord-277417-f71jwdzj	378	8	immune	immune	JJ
cord-277417-f71jwdzj	378	9	activation	activation	NN
cord-277417-f71jwdzj	378	10	,	,	,
cord-277417-f71jwdzj	378	11	proviral	proviral	JJ
cord-277417-f71jwdzj	378	12	load	load	NN
cord-277417-f71jwdzj	378	13	in	in	IN
cord-277417-f71jwdzj	378	14	memory	memory	NN
cord-277417-f71jwdzj	379	1	CD4	CD4	NNP
cord-277417-f71jwdzj	379	2	+	+	CC
cord-277417-f71jwdzj	379	3	T	t	NN
cord-277417-f71jwdzj	379	4	cells	cell	NNS
cord-277417-f71jwdzj	379	5	,	,	,
cord-277417-f71jwdzj	379	6	and	and	CC
cord-277417-f71jwdzj	379	7	disease	disease	NN
cord-277417-f71jwdzj	379	8	progression	progression	NN
cord-277417-f71jwdzj	380	1	Impaired	impair	VBN
cord-277417-f71jwdzj	380	2	replication	replication	NN
cord-277417-f71jwdzj	380	3	capacity	capacity	NN
cord-277417-f71jwdzj	380	4	of	of	IN
cord-277417-f71jwdzj	380	5	acute/	acute/	NNS
cord-277417-f71jwdzj	380	6	early	early	JJ
cord-277417-f71jwdzj	380	7	viruses	virus	NNS
cord-277417-f71jwdzj	380	8	in	in	IN
cord-277417-f71jwdzj	380	9	persons	person	NNS
cord-277417-f71jwdzj	380	10	who	who	WP
cord-277417-f71jwdzj	380	11	become	become	VBP
cord-277417-f71jwdzj	380	12	HIV	HIV	NNP
cord-277417-f71jwdzj	380	13	controllers	controller	NNS
cord-277417-f71jwdzj	380	14	Viral	viral	JJ
cord-277417-f71jwdzj	380	15	genetic	genetic	JJ
cord-277417-f71jwdzj	380	16	variation	variation	NN
cord-277417-f71jwdzj	380	17	accounts	account	VBZ
cord-277417-f71jwdzj	380	18	for	for	IN
cord-277417-f71jwdzj	380	19	a	a	DT
cord-277417-f71jwdzj	380	20	third	third	NN
cord-277417-f71jwdzj	380	21	of	of	IN
cord-277417-f71jwdzj	380	22	variability	variability	NN
cord-277417-f71jwdzj	380	23	in	in	IN
cord-277417-f71jwdzj	380	24	HIV-1	HIV-1	NNP
cord-277417-f71jwdzj	380	25	set	set	NN
cord-277417-f71jwdzj	380	26	-	-	HYPH
cord-277417-f71jwdzj	380	27	point	point	NN
cord-277417-f71jwdzj	380	28	viral	viral	JJ
cord-277417-f71jwdzj	380	29	load	load	NN
cord-277417-f71jwdzj	380	30	in	in	IN
cord-277417-f71jwdzj	380	31	Europe	Europe	NNP
cord-277417-f71jwdzj	380	32	Common	common	JJ
cord-277417-f71jwdzj	380	33	genetic	genetic	JJ
cord-277417-f71jwdzj	380	34	variation	variation	NN
cord-277417-f71jwdzj	380	35	and	and	CC
cord-277417-f71jwdzj	380	36	the	the	DT
cord-277417-f71jwdzj	380	37	control	control	NN
cord-277417-f71jwdzj	380	38	of	of	IN
cord-277417-f71jwdzj	380	39	HIV-1	HIV-1	NNP
cord-277417-f71jwdzj	380	40	in	in	IN
cord-277417-f71jwdzj	380	41	humans	human	NNS
cord-277417-f71jwdzj	380	42	Phylogenetic	Phylogenetic	NNP
cord-277417-f71jwdzj	380	43	approach	approach	NN
cord-277417-f71jwdzj	380	44	reveals	reveal	VBZ
cord-277417-f71jwdzj	380	45	that	that	IN
cord-277417-f71jwdzj	380	46	virus	virus	NN
cord-277417-f71jwdzj	380	47	genotype	genotype	NN
cord-277417-f71jwdzj	380	48	largely	largely	RB
cord-277417-f71jwdzj	380	49	determines	determine	VBZ
cord-277417-f71jwdzj	380	50	HIV	HIV	NNP
cord-277417-f71jwdzj	380	51	set	set	NN
cord-277417-f71jwdzj	380	52	-	-	HYPH
cord-277417-f71jwdzj	380	53	point	point	NN
cord-277417-f71jwdzj	380	54	viral	viral	JJ
cord-277417-f71jwdzj	380	55	load	load	NN
cord-277417-f71jwdzj	380	56	A	a	DT
cord-277417-f71jwdzj	380	57	transmission	transmission	NN
cord-277417-f71jwdzj	380	58	-	-	HYPH
cord-277417-f71jwdzj	380	59	virulence	virulence	NN
cord-277417-f71jwdzj	380	60	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	380	61	trade	trade	NN
cord-277417-f71jwdzj	380	62	-	-	HYPH
cord-277417-f71jwdzj	380	63	off	off	RP
cord-277417-f71jwdzj	380	64	explains	explain	VBZ
cord-277417-f71jwdzj	380	65	attenuation	attenuation	NN
cord-277417-f71jwdzj	380	66	of	of	IN
cord-277417-f71jwdzj	380	67	HIV-1	HIV-1	NNP
cord-277417-f71jwdzj	380	68	in	in	IN
cord-277417-f71jwdzj	380	69	Uganda	Uganda	NNP
cord-277417-f71jwdzj	381	1	Can	Can	MD
cord-277417-f71jwdzj	381	2	Ebola	Ebola	NNP
cord-277417-f71jwdzj	381	3	virus	virus	NN
cord-277417-f71jwdzj	381	4	evolve	evolve	VB
cord-277417-f71jwdzj	381	5	to	to	TO
cord-277417-f71jwdzj	381	6	be	be	VB
cord-277417-f71jwdzj	381	7	less	less	RBR
cord-277417-f71jwdzj	381	8	virulent	virulent	JJ
cord-277417-f71jwdzj	381	9	in	in	IN
cord-277417-f71jwdzj	381	10	humans	human	NNS
cord-277417-f71jwdzj	381	11	?	?	.
cord-277417-f71jwdzj	382	1	This	this	DT
cord-277417-f71jwdzj	382	2	study	study	NN
cord-277417-f71jwdzj	382	3	uses	use	VBZ
cord-277417-f71jwdzj	382	4	a	a	DT
cord-277417-f71jwdzj	382	5	combination	combination	NN
cord-277417-f71jwdzj	382	6	of	of	IN
cord-277417-f71jwdzj	382	7	phylogenetics	phylogenetic	NNS
cord-277417-f71jwdzj	382	8	and	and	CC
cord-277417-f71jwdzj	382	9	experimental	experimental	JJ
cord-277417-f71jwdzj	382	10	study	study	NN
cord-277417-f71jwdzj	382	11	to	to	TO
cord-277417-f71jwdzj	382	12	demonstrate	demonstrate	VB
cord-277417-f71jwdzj	382	13	the	the	DT
cord-277417-f71jwdzj	382	14	importance	importance	NN
cord-277417-f71jwdzj	382	15	of	of	IN
cord-277417-f71jwdzj	382	16	the	the	DT
cord-277417-f71jwdzj	382	17	A82V	A82V	NNP
cord-277417-f71jwdzj	382	18	substitution	substitution	NN
cord-277417-f71jwdzj	382	19	in	in	IN
cord-277417-f71jwdzj	382	20	the	the	DT
cord-277417-f71jwdzj	382	21	EBOV	EBOV	NNP
cord-277417-f71jwdzj	382	22	glycoprotein	glycoprotein	NN
cord-277417-f71jwdzj	382	23	to	to	IN
cord-277417-f71jwdzj	382	24	viral	viral	JJ
cord-277417-f71jwdzj	382	25	infectivity	infectivity	NN
cord-277417-f71jwdzj	382	26	and	and	CC
cord-277417-f71jwdzj	382	27	suggests	suggest	VBZ
cord-277417-f71jwdzj	382	28	that	that	IN
cord-277417-f71jwdzj	382	29	A82V	A82V	NNP
cord-277417-f71jwdzj	382	30	has	have	VBZ
cord-277417-f71jwdzj	382	31	increased	increase	VBN
cord-277417-f71jwdzj	383	1	virus	virus	NN
cord-277417-f71jwdzj	383	2	virulence	virulence	NN
cord-277417-f71jwdzj	383	3	Filovirus	Filovirus	NNP
cord-277417-f71jwdzj	383	4	receptor	receptor	NN
cord-277417-f71jwdzj	383	5	NPC1	NPC1	NNP
cord-277417-f71jwdzj	383	6	contributes	contribute	VBZ
cord-277417-f71jwdzj	383	7	to	to	IN
cord-277417-f71jwdzj	383	8	species	species	NN
cord-277417-f71jwdzj	383	9	-	-	HYPH
cord-277417-f71jwdzj	383	10	specific	specific	JJ
cord-277417-f71jwdzj	383	11	patterns	pattern	NNS
cord-277417-f71jwdzj	383	12	of	of	IN
cord-277417-f71jwdzj	383	13	ebolavirus	ebolavirus	NN
cord-277417-f71jwdzj	383	14	susceptibility	susceptibility	NN
cord-277417-f71jwdzj	383	15	in	in	IN
cord-277417-f71jwdzj	383	16	bats	bat	NNS
cord-277417-f71jwdzj	384	1	Recently	recently	RB
cord-277417-f71jwdzj	384	2	identified	identify	VBN
cord-277417-f71jwdzj	384	3	mutations	mutation	NNS
cord-277417-f71jwdzj	384	4	in	in	IN
cord-277417-f71jwdzj	384	5	the	the	DT
cord-277417-f71jwdzj	384	6	Ebola	Ebola	NNP
cord-277417-f71jwdzj	384	7	virus	virus	NN
cord-277417-f71jwdzj	384	8	-	-	:
cord-277417-f71jwdzj	384	9	Makona	Makona	NNP
cord-277417-f71jwdzj	384	10	genome	genome	NN
cord-277417-f71jwdzj	384	11	do	do	VBP
cord-277417-f71jwdzj	384	12	not	not	RB
cord-277417-f71jwdzj	384	13	alter	alter	VB
cord-277417-f71jwdzj	384	14	pathogenicity	pathogenicity	NN
cord-277417-f71jwdzj	384	15	in	in	IN
cord-277417-f71jwdzj	384	16	animal	animal	NN
cord-277417-f71jwdzj	384	17	models	model	NNS
cord-277417-f71jwdzj	384	18	Zika	Zika	NNP
cord-277417-f71jwdzj	384	19	fever	fever	NN
cord-277417-f71jwdzj	384	20	and	and	CC
cord-277417-f71jwdzj	384	21	congenital	congenital	JJ
cord-277417-f71jwdzj	384	22	Zika	Zika	NNP
cord-277417-f71jwdzj	384	23	syndrome	syndrome	NN
cord-277417-f71jwdzj	384	24	:	:	:
cord-277417-f71jwdzj	384	25	an	an	DT
cord-277417-f71jwdzj	384	26	unexpected	unexpected	JJ
cord-277417-f71jwdzj	384	27	emerging	emerge	VBG
cord-277417-f71jwdzj	384	28	arboviral	arboviral	JJ
cord-277417-f71jwdzj	384	29	disease	disease	NN
cord-277417-f71jwdzj	384	30	Guillain	Guillain	NNP
cord-277417-f71jwdzj	384	31	-	-	HYPH
cord-277417-f71jwdzj	384	32	Barré	Barré	NNP
cord-277417-f71jwdzj	384	33	syndrome	syndrome	NN
cord-277417-f71jwdzj	384	34	outbreak	outbreak	NN
cord-277417-f71jwdzj	384	35	associated	associate	VBN
cord-277417-f71jwdzj	384	36	with	with	IN
cord-277417-f71jwdzj	384	37	Zika	Zika	NNP
cord-277417-f71jwdzj	384	38	virus	virus	NN
cord-277417-f71jwdzj	384	39	infection	infection	NN
cord-277417-f71jwdzj	384	40	in	in	IN
cord-277417-f71jwdzj	384	41	French	French	NNP
cord-277417-f71jwdzj	384	42	Polynesia	Polynesia	NNP
cord-277417-f71jwdzj	384	43	:	:	:
cord-277417-f71jwdzj	384	44	a	a	DT
cord-277417-f71jwdzj	384	45	case	case	NN
cord-277417-f71jwdzj	384	46	-	-	HYPH
cord-277417-f71jwdzj	384	47	control	control	NN
cord-277417-f71jwdzj	384	48	study	study	NN
cord-277417-f71jwdzj	384	49	Zika	Zika	NNP
cord-277417-f71jwdzj	384	50	virus	virus	NN
cord-277417-f71jwdzj	384	51	in	in	IN
cord-277417-f71jwdzj	384	52	the	the	DT
cord-277417-f71jwdzj	384	53	Americas	Americas	NNPS
cord-277417-f71jwdzj	384	54	-yet	-yet	VBZ
cord-277417-f71jwdzj	384	55	another	another	DT
cord-277417-f71jwdzj	384	56	arbovirus	arbovirus	NN
cord-277417-f71jwdzj	384	57	threat	threat	NN
cord-277417-f71jwdzj	384	58	Differential	differential	JJ
cord-277417-f71jwdzj	384	59	virulence	virulence	NN
cord-277417-f71jwdzj	384	60	between	between	IN
cord-277417-f71jwdzj	384	61	Asian	asian	JJ
cord-277417-f71jwdzj	384	62	and	and	CC
cord-277417-f71jwdzj	384	63	African	african	JJ
cord-277417-f71jwdzj	384	64	lineages	lineage	NNS
cord-277417-f71jwdzj	384	65	of	of	IN
cord-277417-f71jwdzj	384	66	Zika	Zika	NNP
cord-277417-f71jwdzj	384	67	virus	virus	NN
cord-277417-f71jwdzj	384	68	Genomic	genomic	JJ
cord-277417-f71jwdzj	384	69	insights	insight	NNS
cord-277417-f71jwdzj	384	70	into	into	IN
cord-277417-f71jwdzj	384	71	Zika	Zika	NNP
cord-277417-f71jwdzj	384	72	virus	virus	NN
cord-277417-f71jwdzj	384	73	emergence	emergence	NN
cord-277417-f71jwdzj	384	74	and	and	CC
cord-277417-f71jwdzj	384	75	spread	spread	VBD
cord-277417-f71jwdzj	384	76	Evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	384	77	enhancement	enhancement	NN
cord-277417-f71jwdzj	384	78	of	of	IN
cord-277417-f71jwdzj	384	79	Zika	Zika	NNP
cord-277417-f71jwdzj	384	80	virus	virus	NN
cord-277417-f71jwdzj	384	81	infectivity	infectivity	NN
cord-277417-f71jwdzj	384	82	in	in	IN
cord-277417-f71jwdzj	384	83	Aedes	Aedes	NNP
cord-277417-f71jwdzj	384	84	aegypti	aegypti	NN
cord-277417-f71jwdzj	385	1	mosquitoes	mosquito	NNS
cord-277417-f71jwdzj	386	1	The	the	DT
cord-277417-f71jwdzj	386	2	results	result	NNS
cord-277417-f71jwdzj	386	3	of	of	IN
cord-277417-f71jwdzj	386	4	this	this	DT
cord-277417-f71jwdzj	386	5	study	study	NN
cord-277417-f71jwdzj	386	6	suggest	suggest	VBP
cord-277417-f71jwdzj	386	7	that	that	IN
cord-277417-f71jwdzj	386	8	a	a	DT
cord-277417-f71jwdzj	386	9	mutation	mutation	NN
cord-277417-f71jwdzj	386	10	in	in	IN
cord-277417-f71jwdzj	386	11	the	the	DT
cord-277417-f71jwdzj	386	12	NS1	ns1	NN
cord-277417-f71jwdzj	386	13	protein	protein	NN
cord-277417-f71jwdzj	386	14	in	in	IN
cord-277417-f71jwdzj	386	15	the	the	DT
cord-277417-f71jwdzj	386	16	ZIKV	ZIKV	NNP
cord-277417-f71jwdzj	386	17	associated	associate	VBN
cord-277417-f71jwdzj	386	18	with	with	IN
cord-277417-f71jwdzj	386	19	the	the	DT
cord-277417-f71jwdzj	386	20	recent	recent	JJ
cord-277417-f71jwdzj	386	21	outbreak	outbreak	NN
cord-277417-f71jwdzj	386	22	in	in	IN
cord-277417-f71jwdzj	386	23	the	the	DT
cord-277417-f71jwdzj	386	24	Americas	Americas	NNPS
cord-277417-f71jwdzj	386	25	causes	cause	VBZ
cord-277417-f71jwdzj	386	26	increased	increase	VBN
cord-277417-f71jwdzj	386	27	infectivity	infectivity	NN
cord-277417-f71jwdzj	386	28	in	in	IN
cord-277417-f71jwdzj	386	29	Aedes	Aedes	NNP
cord-277417-f71jwdzj	386	30	aegypti	aegypti	NN
cord-277417-f71jwdzj	386	31	mosquitoes	mosquitoe	VBZ
cord-277417-f71jwdzj	386	32	A	a	DT
cord-277417-f71jwdzj	386	33	single	single	JJ
cord-277417-f71jwdzj	386	34	mutation	mutation	NN
cord-277417-f71jwdzj	386	35	in	in	IN
cord-277417-f71jwdzj	386	36	the	the	DT
cord-277417-f71jwdzj	386	37	prM	prm	JJ
cord-277417-f71jwdzj	386	38	protein	protein	NN
cord-277417-f71jwdzj	386	39	of	of	IN
cord-277417-f71jwdzj	386	40	Zika	Zika	NNP
cord-277417-f71jwdzj	386	41	virus	virus	NN
cord-277417-f71jwdzj	386	42	contributes	contribute	VBZ
cord-277417-f71jwdzj	386	43	to	to	IN
cord-277417-f71jwdzj	386	44	fetal	fetal	JJ
cord-277417-f71jwdzj	386	45	microcephaly	microcephaly	NNS
cord-277417-f71jwdzj	386	46	Replication	replication	NN
cord-277417-f71jwdzj	386	47	of	of	IN
cord-277417-f71jwdzj	386	48	early	early	JJ
cord-277417-f71jwdzj	386	49	and	and	CC
cord-277417-f71jwdzj	386	50	recent	recent	JJ
cord-277417-f71jwdzj	386	51	Zika	Zika	NNP
cord-277417-f71jwdzj	386	52	virus	virus	NN
cord-277417-f71jwdzj	386	53	isolates	isolate	VBZ
cord-277417-f71jwdzj	386	54	throughout	throughout	IN
cord-277417-f71jwdzj	386	55	mouse	mouse	NN
cord-277417-f71jwdzj	386	56	brain	brain	NN
cord-277417-f71jwdzj	386	57	development	development	NN
cord-277417-f71jwdzj	387	1	The	the	DT
cord-277417-f71jwdzj	387	2	genomics	genomic	NNS
cord-277417-f71jwdzj	387	3	of	of	IN
cord-277417-f71jwdzj	387	4	emerging	emerge	VBG
cord-277417-f71jwdzj	387	5	pathogens	pathogen	NNS
cord-277417-f71jwdzj	387	6	Towards	towards	IN
cord-277417-f71jwdzj	387	7	a	a	DT
cord-277417-f71jwdzj	387	8	genomicsinformed	genomicsinformed	NN
cord-277417-f71jwdzj	387	9	,	,	,
cord-277417-f71jwdzj	387	10	real	real	JJ
cord-277417-f71jwdzj	387	11	-	-	HYPH
cord-277417-f71jwdzj	387	12	time	time	NN
cord-277417-f71jwdzj	387	13	,	,	,
cord-277417-f71jwdzj	387	14	global	global	JJ
cord-277417-f71jwdzj	387	15	pathogen	pathogen	NN
cord-277417-f71jwdzj	387	16	surveillance	surveillance	NN
cord-277417-f71jwdzj	387	17	system	system	NN
cord-277417-f71jwdzj	387	18	Metatranscriptomics	Metatranscriptomics	NNP
cord-277417-f71jwdzj	387	19	and	and	CC
cord-277417-f71jwdzj	387	20	the	the	DT
cord-277417-f71jwdzj	387	21	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	387	22	biology	biology	NN
cord-277417-f71jwdzj	387	23	of	of	IN
cord-277417-f71jwdzj	387	24	RNA	RNA	NNP
cord-277417-f71jwdzj	387	25	viruses	virus	NNS
cord-277417-f71jwdzj	388	1	Predicting	predict	VBG
cord-277417-f71jwdzj	388	2	virus	virus	NN
cord-277417-f71jwdzj	388	3	emergence	emergence	NN
cord-277417-f71jwdzj	388	4	amidst	amidst	IN
cord-277417-f71jwdzj	388	5	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	388	6	noise	noise	NN
cord-277417-f71jwdzj	388	7	Biocontrol	biocontrol	NN
cord-277417-f71jwdzj	388	8	of	of	IN
cord-277417-f71jwdzj	388	9	common	common	JJ
cord-277417-f71jwdzj	388	10	carp	carp	NN
cord-277417-f71jwdzj	388	11	in	in	IN
cord-277417-f71jwdzj	388	12	Australia	Australia	NNP
cord-277417-f71jwdzj	388	13	poses	pose	VBZ
cord-277417-f71jwdzj	388	14	risks	risk	NNS
cord-277417-f71jwdzj	388	15	to	to	IN
cord-277417-f71jwdzj	388	16	biosecurity	biosecurity	NN
cord-277417-f71jwdzj	388	17	Biocontrol	biocontrol	NN
cord-277417-f71jwdzj	388	18	of	of	IN
cord-277417-f71jwdzj	388	19	invasive	invasive	JJ
cord-277417-f71jwdzj	388	20	carp	carp	NN
cord-277417-f71jwdzj	388	21	:	:	:
cord-277417-f71jwdzj	388	22	risks	risk	NNS
cord-277417-f71jwdzj	388	23	abound	abound	VBP
cord-277417-f71jwdzj	388	24	Safe	safe	JJ
cord-277417-f71jwdzj	388	25	and	and	CC
cord-277417-f71jwdzj	388	26	effective	effective	JJ
cord-277417-f71jwdzj	388	27	biocontrol	biocontrol	NN
cord-277417-f71jwdzj	388	28	of	of	IN
cord-277417-f71jwdzj	388	29	common	common	JJ
cord-277417-f71jwdzj	388	30	carp	carp	NN
cord-277417-f71jwdzj	388	31	Cyprinid	Cyprinid	NNP
cord-277417-f71jwdzj	388	32	herpesvirus	herpesvirus	NN
cord-277417-f71jwdzj	388	33	3	3	CD
cord-277417-f71jwdzj	388	34	and	and	CC
cord-277417-f71jwdzj	388	35	its	-PRON-	PRP$
cord-277417-f71jwdzj	388	36	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	388	37	future	future	NN
cord-277417-f71jwdzj	388	38	as	as	IN
cord-277417-f71jwdzj	388	39	a	a	DT
cord-277417-f71jwdzj	388	40	biological	biological	JJ
cord-277417-f71jwdzj	388	41	control	control	NN
cord-277417-f71jwdzj	388	42	agent	agent	NN
cord-277417-f71jwdzj	388	43	for	for	IN
cord-277417-f71jwdzj	388	44	carp	carp	NN
cord-277417-f71jwdzj	388	45	in	in	IN
cord-277417-f71jwdzj	388	46	Australia	Australia	NNP
cord-277417-f71jwdzj	388	47	Virulence	Virulence	NNP
cord-277417-f71jwdzj	388	48	evolution	evolution	NN
cord-277417-f71jwdzj	388	49	in	in	IN
cord-277417-f71jwdzj	388	50	emerging	emerge	VBG
cord-277417-f71jwdzj	388	51	infectious	infectious	JJ
cord-277417-f71jwdzj	388	52	diseases	disease	NNS
cord-277417-f71jwdzj	389	1	Natural	natural	JJ
cord-277417-f71jwdzj	389	2	SIV	SIV	NNP
cord-277417-f71jwdzj	389	3	hosts	host	NNS
cord-277417-f71jwdzj	389	4	:	:	:
cord-277417-f71jwdzj	390	1	Showing	show	VBG
cord-277417-f71jwdzj	390	2	AIDS	AIDS	NNP
cord-277417-f71jwdzj	390	3	the	the	DT
cord-277417-f71jwdzj	390	4	door	door	NN
cord-277417-f71jwdzj	390	5	Understanding	understand	VBG
cord-277417-f71jwdzj	390	6	the	the	DT
cord-277417-f71jwdzj	390	7	benign	benign	JJ
cord-277417-f71jwdzj	390	8	nature	nature	NN
cord-277417-f71jwdzj	390	9	of	of	IN
cord-277417-f71jwdzj	390	10	SIV	SIV	NNP
cord-277417-f71jwdzj	390	11	infection	infection	NN
cord-277417-f71jwdzj	390	12	in	in	IN
cord-277417-f71jwdzj	390	13	natural	natural	JJ
cord-277417-f71jwdzj	390	14	hosts	host	NNS
cord-277417-f71jwdzj	391	1	The	the	DT
cord-277417-f71jwdzj	391	2	results	result	NNS
cord-277417-f71jwdzj	391	3	of	of	IN
cord-277417-f71jwdzj	391	4	this	this	DT
cord-277417-f71jwdzj	391	5	study	study	NN
cord-277417-f71jwdzj	391	6	suggest	suggest	VBP
cord-277417-f71jwdzj	391	7	that	that	IN
cord-277417-f71jwdzj	391	8	simian	simian	JJ
cord-277417-f71jwdzj	391	9	immunodeficiency	immunodeficiency	NN
cord-277417-f71jwdzj	391	10	virus	virus	NN
cord-277417-f71jwdzj	391	11	in	in	IN
cord-277417-f71jwdzj	391	12	chimpanzees	chimpanzee	NNS
cord-277417-f71jwdzj	391	13	,	,	,
cord-277417-f71jwdzj	391	14	which	which	WDT
cord-277417-f71jwdzj	391	15	is	be	VBZ
cord-277417-f71jwdzj	391	16	the	the	DT
cord-277417-f71jwdzj	391	17	ancestor	ancestor	NN
cord-277417-f71jwdzj	391	18	of	of	IN
cord-277417-f71jwdzj	391	19	HIV	HIV	NNP
cord-277417-f71jwdzj	391	20	,	,	,
cord-277417-f71jwdzj	391	21	increases	increase	VBZ
cord-277417-f71jwdzj	391	22	mortality	mortality	NN
cord-277417-f71jwdzj	391	23	in	in	IN
cord-277417-f71jwdzj	391	24	these	these	DT
cord-277417-f71jwdzj	391	25	animals	animal	NNS
cord-277417-f71jwdzj	392	1	Transmission	transmission	NN
cord-277417-f71jwdzj	392	2	of	of	IN
cord-277417-f71jwdzj	392	3	equine	equine	JJ
cord-277417-f71jwdzj	392	4	influenza	influenza	NN
cord-277417-f71jwdzj	392	5	virus	virus	NN
cord-277417-f71jwdzj	392	6	to	to	IN
cord-277417-f71jwdzj	392	7	dogs	dog	NNS
cord-277417-f71jwdzj	392	8	Influenza	Influenza	NNP
cord-277417-f71jwdzj	392	9	virus	virus	NN
cord-277417-f71jwdzj	392	10	reservoirs	reservoir	NNS
cord-277417-f71jwdzj	392	11	and	and	CC
cord-277417-f71jwdzj	392	12	intermediate	intermediate	JJ
cord-277417-f71jwdzj	392	13	hosts	host	NNS
cord-277417-f71jwdzj	392	14	:	:	:
cord-277417-f71jwdzj	393	1	dogs	dog	NNS
cord-277417-f71jwdzj	393	2	,	,	,
cord-277417-f71jwdzj	393	3	horses	horse	NNS
cord-277417-f71jwdzj	393	4	,	,	,
cord-277417-f71jwdzj	393	5	and	and	CC
cord-277417-f71jwdzj	393	6	new	new	JJ
cord-277417-f71jwdzj	393	7	possibilities	possibility	NNS
cord-277417-f71jwdzj	393	8	for	for	IN
cord-277417-f71jwdzj	393	9	influenza	influenza	NN
cord-277417-f71jwdzj	393	10	virus	virus	NN
cord-277417-f71jwdzj	393	11	exposure	exposure	NN
cord-277417-f71jwdzj	393	12	of	of	IN
cord-277417-f71jwdzj	393	13	humans	human	NNS
cord-277417-f71jwdzj	393	14	Equine	equine	JJ
cord-277417-f71jwdzj	393	15	and	and	CC
cord-277417-f71jwdzj	393	16	canine	canine	JJ
cord-277417-f71jwdzj	393	17	influenza	influenza	NN
cord-277417-f71jwdzj	393	18	viruses	virus	NNS
cord-277417-f71jwdzj	393	19	H3N8	H3N8	NNP
cord-277417-f71jwdzj	393	20	viruses	virus	NNS
cord-277417-f71jwdzj	393	21	show	show	VBP
cord-277417-f71jwdzj	393	22	minimal	minimal	JJ
cord-277417-f71jwdzj	393	23	biological	biological	JJ
cord-277417-f71jwdzj	393	24	differences	difference	NNS
cord-277417-f71jwdzj	393	25	despite	despite	IN
cord-277417-f71jwdzj	393	26	phylogenetic	phylogenetic	JJ
cord-277417-f71jwdzj	393	27	divergence	divergence	NN
cord-277417-f71jwdzj	393	28	Rabies	Rabies	NNP
cord-277417-f71jwdzj	393	29	,	,	,
cord-277417-f71jwdzj	393	30	still	still	RB
cord-277417-f71jwdzj	393	31	neglected	neglect	VBN
cord-277417-f71jwdzj	393	32	after	after	IN
cord-277417-f71jwdzj	393	33	125	125	CD
cord-277417-f71jwdzj	393	34	years	year	NNS
cord-277417-f71jwdzj	393	35	of	of	IN
cord-277417-f71jwdzj	393	36	vaccination	vaccination	NN
cord-277417-f71jwdzj	393	37	Virulence	virulence	NN
cord-277417-f71jwdzj	393	38	comparisons	comparison	NNS
cord-277417-f71jwdzj	393	39	of	of	IN
cord-277417-f71jwdzj	393	40	infectious	infectious	JJ
cord-277417-f71jwdzj	393	41	hematopoietic	hematopoietic	JJ
cord-277417-f71jwdzj	393	42	necrosis	necrosis	NN
cord-277417-f71jwdzj	393	43	virus	virus	NN
cord-277417-f71jwdzj	393	44	U	U	NNP
cord-277417-f71jwdzj	393	45	and	and	CC
cord-277417-f71jwdzj	393	46	M	m	CD
cord-277417-f71jwdzj	393	47	genogroups	genogroup	NNS
cord-277417-f71jwdzj	393	48	in	in	IN
cord-277417-f71jwdzj	393	49	sockeye	sockeye	NN
cord-277417-f71jwdzj	393	50	slamon	slamon	NN
cord-277417-f71jwdzj	393	51	and	and	CC
cord-277417-f71jwdzj	393	52	rainbow	rainbow	NN
cord-277417-f71jwdzj	393	53	trout	trout	NN
cord-277417-f71jwdzj	393	54	Differential	differential	JJ
cord-277417-f71jwdzj	393	55	virulence	virulence	NN
cord-277417-f71jwdzj	393	56	mechanisms	mechanism	NNS
cord-277417-f71jwdzj	393	57	of	of	IN
cord-277417-f71jwdzj	393	58	infectious	infectious	JJ
cord-277417-f71jwdzj	393	59	hematopoietic	hematopoietic	JJ
cord-277417-f71jwdzj	393	60	necrosis	necrosis	NN
cord-277417-f71jwdzj	393	61	virus	virus	NN
cord-277417-f71jwdzj	393	62	in	in	IN
cord-277417-f71jwdzj	393	63	rainbow	rainbow	NN
cord-277417-f71jwdzj	393	64	trout	trout	NNP
cord-277417-f71jwdzj	394	1	(	(	-LRB-
cord-277417-f71jwdzj	394	2	Oncorhynchus	Oncorhynchus	NNP
cord-277417-f71jwdzj	394	3	mykiss	mykiss	NN
cord-277417-f71jwdzj	394	4	)	)	-RRB-
cord-277417-f71jwdzj	394	5	include	include	VBP
cord-277417-f71jwdzj	394	6	host	host	NN
cord-277417-f71jwdzj	394	7	entry	entry	NN
cord-277417-f71jwdzj	394	8	and	and	CC
cord-277417-f71jwdzj	394	9	virus	virus	NN
cord-277417-f71jwdzj	394	10	replication	replication	NN
cord-277417-f71jwdzj	394	11	kinetics	kinetics	NNP
cord-277417-f71jwdzj	395	1	The	the	DT
cord-277417-f71jwdzj	395	2	evolution	evolution	NN
cord-277417-f71jwdzj	395	3	of	of	IN
cord-277417-f71jwdzj	395	4	myxoma	myxoma	NNP
cord-277417-f71jwdzj	395	5	virus	virus	NN
cord-277417-f71jwdzj	395	6	:	:	:
cord-277417-f71jwdzj	395	7	genomic	genomic	JJ
cord-277417-f71jwdzj	395	8	and	and	CC
cord-277417-f71jwdzj	395	9	phenotypic	phenotypic	JJ
cord-277417-f71jwdzj	395	10	characterization	characterization	NN
cord-277417-f71jwdzj	395	11	of	of	IN
cord-277417-f71jwdzj	395	12	isolates	isolate	NNS
cord-277417-f71jwdzj	395	13	from	from	IN
cord-277417-f71jwdzj	395	14	Great	Great	NNP
cord-277417-f71jwdzj	395	15	Britain	Britain	NNP
cord-277417-f71jwdzj	395	16	reveals	reveal	VBZ
cord-277417-f71jwdzj	395	17	multiple	multiple	JJ
cord-277417-f71jwdzj	395	18	successful	successful	JJ
cord-277417-f71jwdzj	395	19	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	395	20	pathways	pathway	NNS
cord-277417-f71jwdzj	395	21	distinct	distinct	JJ
cord-277417-f71jwdzj	395	22	from	from	IN
cord-277417-f71jwdzj	395	23	those	those	DT
cord-277417-f71jwdzj	395	24	in	in	IN
cord-277417-f71jwdzj	395	25	Australia	Australia	NNP
cord-277417-f71jwdzj	396	1	Next	next	JJ
cord-277417-f71jwdzj	396	2	step	step	NN
cord-277417-f71jwdzj	396	3	in	in	IN
cord-277417-f71jwdzj	396	4	the	the	DT
cord-277417-f71jwdzj	396	5	ongoing	ongoing	JJ
cord-277417-f71jwdzj	396	6	arms	arm	NNS
cord-277417-f71jwdzj	396	7	race	race	NN
cord-277417-f71jwdzj	396	8	between	between	IN
cord-277417-f71jwdzj	396	9	myxoma	myxoma	NNP
cord-277417-f71jwdzj	396	10	virus	virus	NN
cord-277417-f71jwdzj	396	11	and	and	CC
cord-277417-f71jwdzj	396	12	wild	wild	JJ
cord-277417-f71jwdzj	396	13	rabbits	rabbit	NNS
cord-277417-f71jwdzj	396	14	in	in	IN
cord-277417-f71jwdzj	396	15	Australia	Australia	NNP
cord-277417-f71jwdzj	396	16	is	be	VBZ
cord-277417-f71jwdzj	396	17	a	a	DT
cord-277417-f71jwdzj	396	18	novel	novel	JJ
cord-277417-f71jwdzj	396	19	disease	disease	NN
cord-277417-f71jwdzj	396	20	phenotype	phenotype	NN
cord-277417-f71jwdzj	397	1	A	a	DT
cord-277417-f71jwdzj	397	2	single	single	JJ
cord-277417-f71jwdzj	397	3	-	-	HYPH
cord-277417-f71jwdzj	397	4	amino	amino	NN
cord-277417-f71jwdzj	397	5	-	-	HYPH
cord-277417-f71jwdzj	397	6	acid	acid	NN
cord-277417-f71jwdzj	397	7	substitution	substitution	NN
cord-277417-f71jwdzj	397	8	in	in	IN
cord-277417-f71jwdzj	397	9	the	the	DT
cord-277417-f71jwdzj	397	10	NS1	ns1	NN
cord-277417-f71jwdzj	397	11	protein	protein	NN
cord-277417-f71jwdzj	397	12	changes	change	VBZ
cord-277417-f71jwdzj	397	13	the	the	DT
cord-277417-f71jwdzj	397	14	pathogenicity	pathogenicity	NN
cord-277417-f71jwdzj	397	15	of	of	IN
cord-277417-f71jwdzj	397	16	H5N1	H5N1	NNP
cord-277417-f71jwdzj	397	17	avian	avian	JJ
cord-277417-f71jwdzj	397	18	influenza	influenza	NN
cord-277417-f71jwdzj	397	19	viruses	virus	NNS
cord-277417-f71jwdzj	397	20	in	in	IN
cord-277417-f71jwdzj	397	21	mice	mouse	NNS
cord-277417-f71jwdzj	398	1	A	a	DT
cord-277417-f71jwdzj	398	2	single	single	JJ
cord-277417-f71jwdzj	398	3	amino	amino	NN
cord-277417-f71jwdzj	398	4	acid	acid	NN
cord-277417-f71jwdzj	398	5	in	in	IN
cord-277417-f71jwdzj	398	6	the	the	DT
cord-277417-f71jwdzj	398	7	stalk	stalk	NN
cord-277417-f71jwdzj	398	8	region	region	NN
cord-277417-f71jwdzj	398	9	of	of	IN
cord-277417-f71jwdzj	398	10	the	the	DT
cord-277417-f71jwdzj	398	11	H1N1pdm	H1N1pdm	NNP
cord-277417-f71jwdzj	398	12	influenza	influenza	NN
cord-277417-f71jwdzj	398	13	virus	virus	NN
cord-277417-f71jwdzj	399	1	HA	HA	NNP
cord-277417-f71jwdzj	399	2	protein	protein	NN
cord-277417-f71jwdzj	399	3	affects	affect	VBZ
cord-277417-f71jwdzj	399	4	viral	viral	JJ
cord-277417-f71jwdzj	399	5	fusion	fusion	NN
cord-277417-f71jwdzj	399	6	,	,	,
cord-277417-f71jwdzj	399	7	stability	stability	NN
cord-277417-f71jwdzj	399	8	and	and	CC
cord-277417-f71jwdzj	399	9	infectivity	infectivity	NN
cord-277417-f71jwdzj	399	10	Genetic	genetic	JJ
cord-277417-f71jwdzj	399	11	determinants	determinant	NNS
cord-277417-f71jwdzj	399	12	of	of	IN
cord-277417-f71jwdzj	399	13	Japanese	japanese	JJ
cord-277417-f71jwdzj	399	14	encephalitis	encephalitis	RB
cord-277417-f71jwdzj	399	15	virus	virus	NN
cord-277417-f71jwdzj	399	16	vaccine	vaccine	NN
cord-277417-f71jwdzj	400	1	strain	strain	VB
cord-277417-f71jwdzj	400	2	SA14	SA14	NNP
cord-277417-f71jwdzj	400	3	-	-	HYPH
cord-277417-f71jwdzj	400	4	14	14	CD
cord-277417-f71jwdzj	400	5	-	-	SYM
cord-277417-f71jwdzj	400	6	2	2	CD
cord-277417-f71jwdzj	401	1	that	that	IN
cord-277417-f71jwdzj	401	2	govern	govern	VBP
cord-277417-f71jwdzj	401	3	attenuation	attenuation	NN
cord-277417-f71jwdzj	401	4	of	of	IN
cord-277417-f71jwdzj	401	5	virulence	virulence	NN
cord-277417-f71jwdzj	401	6	in	in	IN
cord-277417-f71jwdzj	401	7	mice	mouse	NNS
cord-277417-f71jwdzj	401	8	Effect	effect	NN
cord-277417-f71jwdzj	401	9	of	of	IN
cord-277417-f71jwdzj	401	10	an	an	DT
cord-277417-f71jwdzj	401	11	88-amino	88-amino	CD
cord-277417-f71jwdzj	401	12	-	-	HYPH
cord-277417-f71jwdzj	401	13	acid	acid	NN
cord-277417-f71jwdzj	401	14	deletion	deletion	NN
cord-277417-f71jwdzj	401	15	in	in	IN
cord-277417-f71jwdzj	401	16	nsp2	nsp2	NN
cord-277417-f71jwdzj	401	17	of	of	IN
cord-277417-f71jwdzj	401	18	porcine	porcine	JJ
cord-277417-f71jwdzj	401	19	reproductive	reproductive	JJ
cord-277417-f71jwdzj	401	20	and	and	CC
cord-277417-f71jwdzj	401	21	respiratory	respiratory	JJ
cord-277417-f71jwdzj	401	22	syndrome	syndrome	NN
cord-277417-f71jwdzj	401	23	virus	virus	NN
cord-277417-f71jwdzj	401	24	on	on	IN
cord-277417-f71jwdzj	401	25	virus	virus	NN
cord-277417-f71jwdzj	401	26	replication	replication	NN
cord-277417-f71jwdzj	401	27	and	and	CC
cord-277417-f71jwdzj	401	28	cytokine	cytokine	NN
cord-277417-f71jwdzj	401	29	responses	response	NNS
cord-277417-f71jwdzj	401	30	in	in	IN
cord-277417-f71jwdzj	401	31	vitro	vitro	FW
cord-277417-f71jwdzj	402	1	The	the	DT
cord-277417-f71jwdzj	402	2	glutamic	glutamic	NN
cord-277417-f71jwdzj	402	3	residue	residue	NN
cord-277417-f71jwdzj	402	4	at	at	IN
cord-277417-f71jwdzj	402	5	position	position	NN
cord-277417-f71jwdzj	402	6	402	402	CD
cord-277417-f71jwdzj	402	7	in	in	IN
cord-277417-f71jwdzj	403	1	the	the	DT
cord-277417-f71jwdzj	403	2	C	C	NNP
cord-277417-f71jwdzj	403	3	-	-	HYPH
cord-277417-f71jwdzj	403	4	terminus	terminus	NN
cord-277417-f71jwdzj	403	5	of	of	IN
cord-277417-f71jwdzj	403	6	Newcastle	Newcastle	NNP
cord-277417-f71jwdzj	403	7	disease	disease	NN
cord-277417-f71jwdzj	403	8	virus	virus	NN
cord-277417-f71jwdzj	403	9	nucleoprotein	nucleoprotein	NNP
cord-277417-f71jwdzj	403	10	is	be	VBZ
cord-277417-f71jwdzj	403	11	critical	critical	JJ
cord-277417-f71jwdzj	403	12	for	for	IN
cord-277417-f71jwdzj	403	13	the	the	DT
cord-277417-f71jwdzj	403	14	virus	virus	NN
cord-277417-f71jwdzj	403	15	Low	low	JJ
cord-277417-f71jwdzj	403	16	evolutionary	evolutionary	JJ
cord-277417-f71jwdzj	403	17	rate	rate	NN
cord-277417-f71jwdzj	403	18	of	of	IN
cord-277417-f71jwdzj	403	19	infectious	infectious	JJ
cord-277417-f71jwdzj	403	20	pancreatic	pancreatic	JJ
cord-277417-f71jwdzj	403	21	necrosis	necrosis	NN
cord-277417-f71jwdzj	403	22	virus	virus	NN
cord-277417-f71jwdzj	403	23	(	(	-LRB-
cord-277417-f71jwdzj	403	24	IPNV	IPNV	NNP
cord-277417-f71jwdzj	403	25	)	)	-RRB-
cord-277417-f71jwdzj	403	26	in	in	IN
cord-277417-f71jwdzj	403	27	Italy	Italy	NNP
cord-277417-f71jwdzj	403	28	is	be	VBZ
cord-277417-f71jwdzj	403	29	associated	associate	VBN
cord-277417-f71jwdzj	403	30	with	with	IN
cord-277417-f71jwdzj	403	31	reduced	reduce	VBN
cord-277417-f71jwdzj	403	32	virulence	virulence	NN
cord-277417-f71jwdzj	403	33	in	in	IN
cord-277417-f71jwdzj	403	34	trout	trout	NN
cord-277417-f71jwdzj	403	35	Characterization	characterization	NN
cord-277417-f71jwdzj	403	36	of	of	IN
cord-277417-f71jwdzj	403	37	an	an	DT
cord-277417-f71jwdzj	403	38	antigenic	antigenic	JJ
cord-277417-f71jwdzj	403	39	determinant	determinant	NN
cord-277417-f71jwdzj	403	40	of	of	IN
cord-277417-f71jwdzj	403	41	the	the	DT
cord-277417-f71jwdzj	403	42	glycoprotein	glycoprotein	NN
cord-277417-f71jwdzj	403	43	that	that	WDT
cord-277417-f71jwdzj	403	44	correlates	correlate	VBZ
cord-277417-f71jwdzj	403	45	with	with	IN
cord-277417-f71jwdzj	403	46	pathogenicity	pathogenicity	NN
cord-277417-f71jwdzj	403	47	of	of	IN
cord-277417-f71jwdzj	403	48	rabies	rabies	NN
cord-277417-f71jwdzj	403	49	virus	virus	NN
cord-277417-f71jwdzj	403	50	M148R	M148R	NNP
cord-277417-f71jwdzj	403	51	and	and	CC
cord-277417-f71jwdzj	403	52	M149R	M149R	NNPS
cord-277417-f71jwdzj	403	53	are	be	VBP
cord-277417-f71jwdzj	403	54	two	two	CD
cord-277417-f71jwdzj	403	55	virulence	virulence	NN
cord-277417-f71jwdzj	403	56	factors	factor	NNS
cord-277417-f71jwdzj	403	57	for	for	IN
cord-277417-f71jwdzj	403	58	myxoma	myxoma	NNP
cord-277417-f71jwdzj	403	59	virus	virus	NN
cord-277417-f71jwdzj	403	60	pathogenesis	pathogenesis	NN
cord-277417-f71jwdzj	403	61	in	in	IN
cord-277417-f71jwdzj	403	62	the	the	DT
cord-277417-f71jwdzj	403	63	European	european	JJ
cord-277417-f71jwdzj	403	64	rabbit	rabbit	NN
cord-277417-f71jwdzj	403	65	Genetic	genetic	JJ
cord-277417-f71jwdzj	403	66	and	and	CC
cord-277417-f71jwdzj	403	67	structural	structural	JJ
cord-277417-f71jwdzj	403	68	analysis	analysis	NN
cord-277417-f71jwdzj	403	69	of	of	IN
cord-277417-f71jwdzj	403	70	a	a	DT
cord-277417-f71jwdzj	403	71	virulence	virulence	NN
cord-277417-f71jwdzj	403	72	determinant	determinant	NN
cord-277417-f71jwdzj	403	73	in	in	IN
cord-277417-f71jwdzj	403	74	polyomavirus	polyomavirus	JJ
cord-277417-f71jwdzj	403	75	VP1	VP1	NNP
cord-277417-f71jwdzj	403	76	Sheeppox	Sheeppox	NNP
cord-277417-f71jwdzj	403	77	virus	virus	NN
cord-277417-f71jwdzj	403	78	kelch	kelch	NN
cord-277417-f71jwdzj	403	79	-	-	HYPH
cord-277417-f71jwdzj	403	80	like	like	JJ
cord-277417-f71jwdzj	403	81	gene	gene	NN
cord-277417-f71jwdzj	403	82	SPPV-019	SPPV-019	NNP
cord-277417-f71jwdzj	403	83	affects	affect	VBZ
cord-277417-f71jwdzj	404	1	virus	virus	NN
cord-277417-f71jwdzj	404	2	virulence	virulence	NN
cord-277417-f71jwdzj	404	3	RElaTED	relate	VBN
cord-277417-f71jwdzj	404	4	links	link	VBZ
cord-277417-f71jwdzj	404	5	National	National	NNP
cord-277417-f71jwdzj	404	6	Geographic	Geographic	NNP
cord-277417-f71jwdzj	404	7	:	:	:
cord-277417-f71jwdzj	405	1	leaky	leaky	JJ
cord-277417-f71jwdzj	405	2	vaccines	vaccine	NNS
cord-277417-f71jwdzj	405	3	enhance	enhance	VBP
cord-277417-f71jwdzj	405	4	spread	spread	NN
cord-277417-f71jwdzj	405	5	of	of	IN
cord-277417-f71jwdzj	405	6	deadlier	deadly	JJR
cord-277417-f71jwdzj	405	7	chicken	chicken	NN
cord-277417-f71jwdzj	405	8	viruses	virus	NNS
cord-277417-f71jwdzj	406	1	Both	both	DT
cord-277417-f71jwdzj	406	2	authors	author	NNS
cord-277417-f71jwdzj	406	3	contributed	contribute	VBD
cord-277417-f71jwdzj	406	4	to	to	IN
cord-277417-f71jwdzj	406	5	all	all	DT
cord-277417-f71jwdzj	406	6	aspects	aspect	NNS
cord-277417-f71jwdzj	406	7	of	of	IN
cord-277417-f71jwdzj	406	8	the	the	DT
cord-277417-f71jwdzj	406	9	manuscript	manuscript	NN
cord-277417-f71jwdzj	406	10	.	.	.
cord-277417-f71jwdzj	407	1	The	the	DT
cord-277417-f71jwdzj	407	2	authors	author	NNS
cord-277417-f71jwdzj	407	3	declare	declare	VBP
cord-277417-f71jwdzj	407	4	no	no	DT
cord-277417-f71jwdzj	407	5	competing	compete	VBG
cord-277417-f71jwdzj	407	6	interests	interest	NNS
cord-277417-f71jwdzj	407	7	.	.	.
cord-277417-f71jwdzj	408	1	Springer	Springer	NNP
cord-277417-f71jwdzj	408	2	Nature	Nature	NNP
cord-277417-f71jwdzj	408	3	remains	remain	VBZ
cord-277417-f71jwdzj	408	4	neutral	neutral	JJ
cord-277417-f71jwdzj	408	5	with	with	IN
cord-277417-f71jwdzj	408	6	regard	regard	NN
cord-277417-f71jwdzj	408	7	to	to	IN
cord-277417-f71jwdzj	408	8	jurisdictional	jurisdictional	JJ
cord-277417-f71jwdzj	408	9	claims	claim	NNS
cord-277417-f71jwdzj	408	10	in	in	IN
cord-277417-f71jwdzj	408	11	published	publish	VBN
cord-277417-f71jwdzj	408	12	maps	map	NNS
cord-277417-f71jwdzj	408	13	and	and	CC
cord-277417-f71jwdzj	408	14	institutional	institutional	JJ
cord-277417-f71jwdzj	408	15	affiliations	affiliation	NNS
cord-277417-f71jwdzj	408	16	.	.	.
cord-277417-f71jwdzj	409	1	Nature	Nature	NNP
cord-277417-f71jwdzj	409	2	Reviews	Reviews	NNPS
cord-277417-f71jwdzj	409	3	Genetics	Genetics	NNP
cord-277417-f71jwdzj	409	4	thanks	thank	NNS
cord-277417-f71jwdzj	409	5	S.	S.	NNP
cord-277417-f71jwdzj	409	6	Alizon	Alizon	NNP
cord-277417-f71jwdzj	409	7	and	and	CC
cord-277417-f71jwdzj	409	8	the	the	DT
cord-277417-f71jwdzj	409	9	other	other	JJ
cord-277417-f71jwdzj	409	10	,	,	,
cord-277417-f71jwdzj	409	11	anonymous	anonymous	JJ
cord-277417-f71jwdzj	409	12	reviewer(s	reviewer(s	NNP
cord-277417-f71jwdzj	409	13	)	)	-RRB-
cord-277417-f71jwdzj	409	14	for	for	IN
cord-277417-f71jwdzj	409	15	their	-PRON-	PRP$
cord-277417-f71jwdzj	409	16	contribution	contribution	NN
cord-277417-f71jwdzj	409	17	to	to	IN
cord-277417-f71jwdzj	409	18	the	the	DT
cord-277417-f71jwdzj	409	19	peer	peer	NN
cord-277417-f71jwdzj	409	20	review	review	NN
cord-277417-f71jwdzj	409	21	of	of	IN
cord-277417-f71jwdzj	409	22	this	this	DT
cord-277417-f71jwdzj	409	23	work	work	NN
cord-277417-f71jwdzj	409	24	.	.	.