id	sid	tid	token	lemma	pos
cord-264884-ydkigome	1	1	key	key	NNP
cord-264884-ydkigome	1	2	:	:	:
cord-264884-ydkigome	1	3	cord-264884-ydkigome	cord-264884-ydkigome	NNP
cord-264884-ydkigome	2	1	authors	author	NNS
cord-264884-ydkigome	2	2	:	:	:
cord-264884-ydkigome	2	3	Villarreal	Villarreal	NNP
cord-264884-ydkigome	2	4	,	,	,
cord-264884-ydkigome	2	5	Luis	Luis	NNP
cord-264884-ydkigome	2	6	P.	P.	NNP
cord-264884-ydkigome	2	7	title	title	NN
cord-264884-ydkigome	2	8	:	:	:
cord-264884-ydkigome	3	1	The	the	DT
cord-264884-ydkigome	3	2	Widespread	Widespread	NNP
cord-264884-ydkigome	3	3	Evolutionary	evolutionary	JJ
cord-264884-ydkigome	3	4	Significance	significance	NN
cord-264884-ydkigome	3	5	of	of	IN
cord-264884-ydkigome	3	6	Viruses	virus	NNS
cord-264884-ydkigome	3	7	date	date	NN
cord-264884-ydkigome	3	8	:	:	:
cord-264884-ydkigome	3	9	2008	2008	CD
cord-264884-ydkigome	3	10	-	-	SYM
cord-264884-ydkigome	3	11	07	07	CD
cord-264884-ydkigome	3	12	-	-	HYPH
cord-264884-ydkigome	3	13	05	05	CD
cord-264884-ydkigome	3	14	journal	journal	NN
cord-264884-ydkigome	3	15	:	:	:
cord-264884-ydkigome	4	1	Origin	Origin	NNP
cord-264884-ydkigome	4	2	and	and	CC
cord-264884-ydkigome	4	3	Evolution	Evolution	NNP
cord-264884-ydkigome	4	4	of	of	IN
cord-264884-ydkigome	4	5	Viruses	virus	NNS
cord-264884-ydkigome	4	6	DOI	DOI	NNP
cord-264884-ydkigome	4	7	:	:	:
cord-264884-ydkigome	4	8	10.1016	10.1016	CD
cord-264884-ydkigome	4	9	/	/	SYM
cord-264884-ydkigome	4	10	b978	b978	NN
cord-264884-ydkigome	4	11	-	-	HYPH
cord-264884-ydkigome	4	12	0	0	CD
cord-264884-ydkigome	4	13	-	-	HYPH
cord-264884-ydkigome	4	14	12	12	CD
cord-264884-ydkigome	4	15	-	-	HYPH
cord-264884-ydkigome	4	16	374153	374153	CD
cord-264884-ydkigome	4	17	-	-	HYPH
cord-264884-ydkigome	4	18	0.00021	0.00021	CD
cord-264884-ydkigome	4	19	-	-	SYM
cord-264884-ydkigome	4	20	7	7	CD
cord-264884-ydkigome	4	21	sha	sha	NN
cord-264884-ydkigome	4	22	:	:	:
cord-264884-ydkigome	4	23	6974a925827dbe9893dcf9f3c8ac0bc69ae7c756	6974a925827dbe9893dcf9f3c8ac0bc69ae7c756	CD
cord-264884-ydkigome	4	24	doc_id	doc_id	CD
cord-264884-ydkigome	4	25	:	:	:
cord-264884-ydkigome	4	26	264884	264884	CD
cord-264884-ydkigome	4	27	cord_uid	cord_uid	NNS
cord-264884-ydkigome	4	28	:	:	:
cord-264884-ydkigome	4	29	ydkigome	ydkigome	JJ
cord-264884-ydkigome	5	1	In	in	IN
cord-264884-ydkigome	5	2	the	the	DT
cord-264884-ydkigome	5	3	last	last	JJ
cord-264884-ydkigome	5	4	30	30	CD
cord-264884-ydkigome	5	5	years	year	NNS
cord-264884-ydkigome	5	6	,	,	,
cord-264884-ydkigome	5	7	the	the	DT
cord-264884-ydkigome	5	8	study	study	NN
cord-264884-ydkigome	5	9	of	of	IN
cord-264884-ydkigome	5	10	virus	virus	NN
cord-264884-ydkigome	5	11	evolution	evolution	NN
cord-264884-ydkigome	5	12	has	have	VBZ
cord-264884-ydkigome	5	13	undergone	undergo	VBN
cord-264884-ydkigome	5	14	a	a	DT
cord-264884-ydkigome	5	15	transformation	transformation	NN
cord-264884-ydkigome	5	16	.	.	.
cord-264884-ydkigome	6	1	Originally	originally	RB
cord-264884-ydkigome	6	2	concerned	concern	VBN
cord-264884-ydkigome	6	3	with	with	IN
cord-264884-ydkigome	6	4	disease	disease	NN
cord-264884-ydkigome	6	5	and	and	CC
cord-264884-ydkigome	6	6	its	-PRON-	PRP$
cord-264884-ydkigome	6	7	emergence	emergence	NN
cord-264884-ydkigome	6	8	,	,	,
cord-264884-ydkigome	6	9	virus	virus	NN
cord-264884-ydkigome	6	10	evolution	evolution	NN
cord-264884-ydkigome	6	11	had	have	VBD
cord-264884-ydkigome	6	12	not	not	RB
cord-264884-ydkigome	6	13	been	be	VBN
cord-264884-ydkigome	6	14	well	well	RB
cord-264884-ydkigome	6	15	integrated	integrate	VBN
cord-264884-ydkigome	6	16	into	into	IN
cord-264884-ydkigome	6	17	the	the	DT
cord-264884-ydkigome	6	18	general	general	JJ
cord-264884-ydkigome	6	19	study	study	NN
cord-264884-ydkigome	6	20	of	of	IN
cord-264884-ydkigome	6	21	evolution	evolution	NN
cord-264884-ydkigome	6	22	.	.	.
cord-264884-ydkigome	7	1	This	this	DT
cord-264884-ydkigome	7	2	chapter	chapter	NN
cord-264884-ydkigome	7	3	reviews	review	VBZ
cord-264884-ydkigome	7	4	the	the	DT
cord-264884-ydkigome	7	5	developments	development	NNS
cord-264884-ydkigome	7	6	that	that	WDT
cord-264884-ydkigome	7	7	have	have	VBP
cord-264884-ydkigome	7	8	brought	bring	VBN
cord-264884-ydkigome	7	9	us	-PRON-	PRP
cord-264884-ydkigome	7	10	to	to	IN
cord-264884-ydkigome	7	11	this	this	DT
cord-264884-ydkigome	7	12	new	new	JJ
cord-264884-ydkigome	7	13	appreciation	appreciation	NN
cord-264884-ydkigome	7	14	for	for	IN
cord-264884-ydkigome	7	15	the	the	DT
cord-264884-ydkigome	7	16	general	general	JJ
cord-264884-ydkigome	7	17	significance	significance	NN
cord-264884-ydkigome	7	18	of	of	IN
cord-264884-ydkigome	7	19	virus	virus	NN
cord-264884-ydkigome	7	20	evolution	evolution	NN
cord-264884-ydkigome	7	21	to	to	IN
cord-264884-ydkigome	7	22	all	all	DT
cord-264884-ydkigome	7	23	life	life	NN
cord-264884-ydkigome	7	24	.	.	.
cord-264884-ydkigome	8	1	We	-PRON-	PRP
cord-264884-ydkigome	8	2	now	now	RB
cord-264884-ydkigome	8	3	know	know	VBP
cord-264884-ydkigome	8	4	that	that	IN
cord-264884-ydkigome	8	5	viruses	virus	NNS
cord-264884-ydkigome	8	6	numerically	numerically	RB
cord-264884-ydkigome	8	7	dominate	dominate	VBP
cord-264884-ydkigome	8	8	all	all	DT
cord-264884-ydkigome	8	9	habitats	habitat	NNS
cord-264884-ydkigome	8	10	of	of	IN
cord-264884-ydkigome	8	11	life	life	NN
cord-264884-ydkigome	8	12	,	,	,
cord-264884-ydkigome	8	13	especially	especially	RB
cord-264884-ydkigome	8	14	the	the	DT
cord-264884-ydkigome	8	15	oceans	ocean	NNS
cord-264884-ydkigome	8	16	.	.	.
cord-264884-ydkigome	9	1	Theoretical	theoretical	JJ
cord-264884-ydkigome	9	2	developments	development	NNS
cord-264884-ydkigome	9	3	in	in	IN
cord-264884-ydkigome	9	4	the	the	DT
cord-264884-ydkigome	9	5	1970s	1970	NNS
cord-264884-ydkigome	9	6	regarding	regard	VBG
cord-264884-ydkigome	9	7	quasispecies	quasispecie	NNS
cord-264884-ydkigome	9	8	,	,	,
cord-264884-ydkigome	9	9	error	error	NN
cord-264884-ydkigome	9	10	rates	rate	NNS
cord-264884-ydkigome	9	11	,	,	,
cord-264884-ydkigome	9	12	and	and	CC
cord-264884-ydkigome	9	13	error	error	NN
cord-264884-ydkigome	9	14	thresholds	threshold	NNS
cord-264884-ydkigome	9	15	have	have	VBP
cord-264884-ydkigome	9	16	yielded	yield	VBN
cord-264884-ydkigome	9	17	many	many	JJ
cord-264884-ydkigome	9	18	practical	practical	JJ
cord-264884-ydkigome	9	19	insights	insight	NNS
cord-264884-ydkigome	9	20	into	into	IN
cord-264884-ydkigome	9	21	virus	virus	NN
cord-264884-ydkigome	9	22	–	–	:
cord-264884-ydkigome	9	23	host	host	NN
cord-264884-ydkigome	9	24	dynamics	dynamic	NNS
cord-264884-ydkigome	9	25	.	.	.
cord-264884-ydkigome	10	1	The	the	DT
cord-264884-ydkigome	10	2	human	human	JJ
cord-264884-ydkigome	10	3	diseases	disease	NNS
cord-264884-ydkigome	10	4	of	of	IN
cord-264884-ydkigome	10	5	HIV-1	HIV-1	NNP
cord-264884-ydkigome	10	6	and	and	CC
cord-264884-ydkigome	10	7	hepatitis	hepatitis	NNP
cord-264884-ydkigome	10	8	C	C	NNP
cord-264884-ydkigome	10	9	virus	virus	NN
cord-264884-ydkigome	10	10	can	can	MD
cord-264884-ydkigome	10	11	not	not	RB
cord-264884-ydkigome	10	12	be	be	VB
cord-264884-ydkigome	10	13	understood	understand	VBN
cord-264884-ydkigome	10	14	without	without	IN
cord-264884-ydkigome	10	15	this	this	DT
cord-264884-ydkigome	10	16	evolutionary	evolutionary	JJ
cord-264884-ydkigome	10	17	framework	framework	NN
cord-264884-ydkigome	10	18	.	.	.
cord-264884-ydkigome	11	1	Yet	yet	CC
cord-264884-ydkigome	11	2	recent	recent	JJ
cord-264884-ydkigome	11	3	developments	development	NNS
cord-264884-ydkigome	11	4	with	with	IN
cord-264884-ydkigome	11	5	poliovirus	poliovirus	NN
cord-264884-ydkigome	11	6	demonstrate	demonstrate	VBP
cord-264884-ydkigome	11	7	that	that	IN
cord-264884-ydkigome	11	8	viral	viral	JJ
cord-264884-ydkigome	11	9	fitness	fitness	NN
cord-264884-ydkigome	11	10	can	can	MD
cord-264884-ydkigome	11	11	be	be	VB
cord-264884-ydkigome	11	12	the	the	DT
cord-264884-ydkigome	11	13	result	result	NN
cord-264884-ydkigome	11	14	of	of	IN
cord-264884-ydkigome	11	15	a	a	DT
cord-264884-ydkigome	11	16	consortia	consortia	NN
cord-264884-ydkigome	11	17	,	,	,
cord-264884-ydkigome	11	18	not	not	RB
cord-264884-ydkigome	11	19	one	one	CD
cord-264884-ydkigome	11	20	fittest	fit	JJS
cord-264884-ydkigome	11	21	type	type	NN
cord-264884-ydkigome	11	22	,	,	,
cord-264884-ydkigome	11	23	a	a	DT
cord-264884-ydkigome	11	24	basic	basic	JJ
cord-264884-ydkigome	11	25	Darwinian	darwinian	JJ
cord-264884-ydkigome	11	26	concept	concept	NN
cord-264884-ydkigome	11	27	in	in	IN
cord-264884-ydkigome	11	28	evolutionary	evolutionary	JJ
cord-264884-ydkigome	11	29	biology	biology	NN
cord-264884-ydkigome	11	30	.	.	.
cord-264884-ydkigome	12	1	Darwinian	darwinian	JJ
cord-264884-ydkigome	12	2	principles	principle	NNS
cord-264884-ydkigome	12	3	do	do	VBP
cord-264884-ydkigome	12	4	apply	apply	VB
cord-264884-ydkigome	12	5	to	to	IN
cord-264884-ydkigome	12	6	viruses	virus	NNS
cord-264884-ydkigome	12	7	,	,	,
cord-264884-ydkigome	12	8	such	such	JJ
cord-264884-ydkigome	12	9	as	as	IN
cord-264884-ydkigome	12	10	with	with	IN
cord-264884-ydkigome	12	11	Fisher	Fisher	NNP
cord-264884-ydkigome	12	12	population	population	NN
cord-264884-ydkigome	12	13	genetics	genetic	NNS
cord-264884-ydkigome	12	14	,	,	,
cord-264884-ydkigome	12	15	but	but	CC
cord-264884-ydkigome	12	16	other	other	JJ
cord-264884-ydkigome	12	17	features	feature	NNS
cord-264884-ydkigome	12	18	,	,	,
cord-264884-ydkigome	12	19	such	such	JJ
cord-264884-ydkigome	12	20	as	as	IN
cord-264884-ydkigome	12	21	reticulated	reticulated	JJ
cord-264884-ydkigome	12	22	and	and	CC
cord-264884-ydkigome	12	23	quasispecies	quasispecie	NNS
cord-264884-ydkigome	12	24	-	-	HYPH
cord-264884-ydkigome	12	25	based	base	VBN
cord-264884-ydkigome	12	26	evolution	evolution	NN
cord-264884-ydkigome	12	27	distinguish	distinguish	VBP
cord-264884-ydkigome	12	28	virus	virus	NN
cord-264884-ydkigome	12	29	evolution	evolution	NN
cord-264884-ydkigome	12	30	from	from	IN
cord-264884-ydkigome	12	31	classical	classical	JJ
cord-264884-ydkigome	12	32	studies	study	NNS
cord-264884-ydkigome	12	33	.	.	.
cord-264884-ydkigome	13	1	The	the	DT
cord-264884-ydkigome	13	2	available	available	JJ
cord-264884-ydkigome	13	3	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	13	4	tools	tool	NNS
cord-264884-ydkigome	13	5	have	have	VBP
cord-264884-ydkigome	13	6	greatly	greatly	RB
cord-264884-ydkigome	13	7	aided	aid	VBN
cord-264884-ydkigome	13	8	our	-PRON-	PRP$
cord-264884-ydkigome	13	9	analysis	analysis	NN
cord-264884-ydkigome	13	10	of	of	IN
cord-264884-ydkigome	13	11	virus	virus	NN
cord-264884-ydkigome	13	12	evolution	evolution	NN
cord-264884-ydkigome	13	13	,	,	,
cord-264884-ydkigome	13	14	but	but	CC
cord-264884-ydkigome	13	15	these	these	DT
cord-264884-ydkigome	13	16	methods	method	NNS
cord-264884-ydkigome	13	17	struggle	struggle	VBP
cord-264884-ydkigome	13	18	to	to	TO
cord-264884-ydkigome	13	19	characterize	characterize	VB
cord-264884-ydkigome	13	20	the	the	DT
cord-264884-ydkigome	13	21	role	role	NN
cord-264884-ydkigome	13	22	of	of	IN
cord-264884-ydkigome	13	23	virus	virus	NN
cord-264884-ydkigome	13	24	populations	population	NNS
cord-264884-ydkigome	13	25	.	.	.
cord-264884-ydkigome	14	1	Missing	miss	VBG
cord-264884-ydkigome	14	2	from	from	IN
cord-264884-ydkigome	14	3	many	many	JJ
cord-264884-ydkigome	14	4	of	of	IN
cord-264884-ydkigome	14	5	these	these	DT
cord-264884-ydkigome	14	6	considerations	consideration	NNS
cord-264884-ydkigome	14	7	has	have	VBZ
cord-264884-ydkigome	14	8	been	be	VBN
cord-264884-ydkigome	14	9	the	the	DT
cord-264884-ydkigome	14	10	major	major	JJ
cord-264884-ydkigome	14	11	role	role	NN
cord-264884-ydkigome	14	12	played	play	VBN
cord-264884-ydkigome	14	13	by	by	IN
cord-264884-ydkigome	14	14	persisting	persist	VBG
cord-264884-ydkigome	14	15	viruses	virus	NNS
cord-264884-ydkigome	14	16	in	in	IN
cord-264884-ydkigome	14	17	stable	stable	JJ
cord-264884-ydkigome	14	18	virus	virus	NN
cord-264884-ydkigome	14	19	evolution	evolution	NN
cord-264884-ydkigome	14	20	and	and	CC
cord-264884-ydkigome	14	21	disease	disease	NN
cord-264884-ydkigome	14	22	emergence	emergence	NN
cord-264884-ydkigome	14	23	.	.	.
cord-264884-ydkigome	15	1	In	in	IN
cord-264884-ydkigome	15	2	many	many	JJ
cord-264884-ydkigome	15	3	cases	case	NNS
cord-264884-ydkigome	15	4	,	,	,
cord-264884-ydkigome	15	5	extreme	extreme	JJ
cord-264884-ydkigome	15	6	stability	stability	NN
cord-264884-ydkigome	15	7	is	be	VBZ
cord-264884-ydkigome	15	8	seen	see	VBN
cord-264884-ydkigome	15	9	with	with	IN
cord-264884-ydkigome	15	10	persisting	persist	VBG
cord-264884-ydkigome	15	11	RNA	RNA	NNP
cord-264884-ydkigome	15	12	viruses	virus	NNS
cord-264884-ydkigome	15	13	.	.	.
cord-264884-ydkigome	16	1	Indeed	indeed	RB
cord-264884-ydkigome	16	2	,	,	,
cord-264884-ydkigome	16	3	examples	example	NNS
cord-264884-ydkigome	16	4	are	be	VBP
cord-264884-ydkigome	16	5	known	know	VBN
cord-264884-ydkigome	16	6	in	in	IN
cord-264884-ydkigome	16	7	which	which	WDT
cord-264884-ydkigome	16	8	it	-PRON-	PRP
cord-264884-ydkigome	16	9	is	be	VBZ
cord-264884-ydkigome	16	10	the	the	DT
cord-264884-ydkigome	16	11	persistently	persistently	RB
cord-264884-ydkigome	16	12	infected	infect	VBN
cord-264884-ydkigome	16	13	host	host	NN
cord-264884-ydkigome	16	14	that	that	WDT
cord-264884-ydkigome	16	15	has	have	VBZ
cord-264884-ydkigome	16	16	better	well	JJR
cord-264884-ydkigome	16	17	survival	survival	NN
cord-264884-ydkigome	16	18	.	.	.
cord-264884-ydkigome	17	1	We	-PRON-	PRP
cord-264884-ydkigome	17	2	have	have	VBP
cord-264884-ydkigome	17	3	also	also	RB
cord-264884-ydkigome	17	4	recently	recently	RB
cord-264884-ydkigome	17	5	come	come	VBN
cord-264884-ydkigome	17	6	to	to	TO
cord-264884-ydkigome	17	7	appreciate	appreciate	VB
cord-264884-ydkigome	17	8	the	the	DT
cord-264884-ydkigome	17	9	vast	vast	JJ
cord-264884-ydkigome	17	10	diversity	diversity	NN
cord-264884-ydkigome	17	11	of	of	IN
cord-264884-ydkigome	17	12	phage	phage	NN
cord-264884-ydkigome	17	13	(	(	-LRB-
cord-264884-ydkigome	17	14	DNA	dna	NN
cord-264884-ydkigome	17	15	viruses	virus	NNS
cord-264884-ydkigome	17	16	)	)	-RRB-
cord-264884-ydkigome	17	17	of	of	IN
cord-264884-ydkigome	17	18	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	17	19	as	as	IN
cord-264884-ydkigome	17	20	a	a	DT
cord-264884-ydkigome	17	21	system	system	NN
cord-264884-ydkigome	17	22	that	that	WDT
cord-264884-ydkigome	17	23	evolves	evolve	VBZ
cord-264884-ydkigome	17	24	by	by	IN
cord-264884-ydkigome	17	25	genetic	genetic	JJ
cord-264884-ydkigome	17	26	exchanges	exchange	NNS
cord-264884-ydkigome	17	27	across	across	IN
cord-264884-ydkigome	17	28	vast	vast	JJ
cord-264884-ydkigome	17	29	populations	population	NNS
cord-264884-ydkigome	17	30	(	(	-LRB-
cord-264884-ydkigome	17	31	Chapter	chapter	NN
cord-264884-ydkigome	17	32	10	10	CD
cord-264884-ydkigome	17	33	)	)	-RRB-
cord-264884-ydkigome	17	34	.	.	.
cord-264884-ydkigome	18	1	This	this	DT
cord-264884-ydkigome	18	2	has	have	VBZ
cord-264884-ydkigome	18	3	been	be	VBN
cord-264884-ydkigome	18	4	proposed	propose	VBN
cord-264884-ydkigome	18	5	to	to	TO
cord-264884-ydkigome	18	6	be	be	VB
cord-264884-ydkigome	18	7	the	the	DT
cord-264884-ydkigome	18	8	“	"	``
cord-264884-ydkigome	18	9	big	big	JJ
cord-264884-ydkigome	18	10	bang	bang	NN
cord-264884-ydkigome	18	11	”	"	''
cord-264884-ydkigome	18	12	of	of	IN
cord-264884-ydkigome	18	13	biological	biological	JJ
cord-264884-ydkigome	18	14	evolution	evolution	NN
cord-264884-ydkigome	18	15	.	.	.
cord-264884-ydkigome	19	1	In	in	IN
cord-264884-ydkigome	19	2	the	the	DT
cord-264884-ydkigome	19	3	large	large	JJ
cord-264884-ydkigome	19	4	DNA	dna	NN
cord-264884-ydkigome	19	5	viruses	virus	NNS
cord-264884-ydkigome	19	6	of	of	IN
cord-264884-ydkigome	19	7	aquatic	aquatic	JJ
cord-264884-ydkigome	19	8	microbes	microbe	NNS
cord-264884-ydkigome	19	9	we	-PRON-	PRP
cord-264884-ydkigome	19	10	see	see	VBP
cord-264884-ydkigome	19	11	surprisingly	surprisingly	RB
cord-264884-ydkigome	19	12	large	large	JJ
cord-264884-ydkigome	19	13	,	,	,
cord-264884-ydkigome	19	14	complex	complex	JJ
cord-264884-ydkigome	19	15	and	and	CC
cord-264884-ydkigome	19	16	diverse	diverse	JJ
cord-264884-ydkigome	19	17	viruses	virus	NNS
cord-264884-ydkigome	19	18	.	.	.
cord-264884-ydkigome	20	1	With	with	IN
cord-264884-ydkigome	20	2	both	both	DT
cord-264884-ydkigome	20	3	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	20	4	and	and	CC
cord-264884-ydkigome	20	5	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	20	6	DNA	dna	NN
cord-264884-ydkigome	20	7	viruses	virus	NNS
cord-264884-ydkigome	20	8	,	,	,
cord-264884-ydkigome	20	9	recombination	recombination	NN
cord-264884-ydkigome	20	10	is	be	VBZ
cord-264884-ydkigome	20	11	the	the	DT
cord-264884-ydkigome	20	12	main	main	JJ
cord-264884-ydkigome	20	13	engine	engine	NN
cord-264884-ydkigome	20	14	of	of	IN
cord-264884-ydkigome	20	15	virus	virus	NN
cord-264884-ydkigome	20	16	evolution	evolution	NN
cord-264884-ydkigome	20	17	,	,	,
cord-264884-ydkigome	20	18	and	and	CC
cord-264884-ydkigome	20	19	virus	virus	NN
cord-264884-ydkigome	20	20	host	host	NN
cord-264884-ydkigome	20	21	co	co	NN
cord-264884-ydkigome	20	22	-	-	NN
cord-264884-ydkigome	20	23	evolution	evolution	NN
cord-264884-ydkigome	20	24	is	be	VBZ
cord-264884-ydkigome	20	25	common	common	JJ
cord-264884-ydkigome	20	26	,	,	,
cord-264884-ydkigome	20	27	although	although	IN
cord-264884-ydkigome	20	28	not	not	RB
cord-264884-ydkigome	20	29	uniform	uniform	JJ
cord-264884-ydkigome	20	30	.	.	.
cord-264884-ydkigome	21	1	Viral	viral	JJ
cord-264884-ydkigome	21	2	emergence	emergence	NN
cord-264884-ydkigome	21	3	appears	appear	VBZ
cord-264884-ydkigome	21	4	to	to	TO
cord-264884-ydkigome	21	5	be	be	VB
cord-264884-ydkigome	21	6	an	an	DT
cord-264884-ydkigome	21	7	unending	unending	JJ
cord-264884-ydkigome	21	8	phenomenon	phenomenon	NN
cord-264884-ydkigome	21	9	and	and	CC
cord-264884-ydkigome	21	10	we	-PRON-	PRP
cord-264884-ydkigome	21	11	can	can	MD
cord-264884-ydkigome	21	12	currently	currently	RB
cord-264884-ydkigome	21	13	witness	witness	VB
cord-264884-ydkigome	21	14	a	a	DT
cord-264884-ydkigome	21	15	selective	selective	JJ
cord-264884-ydkigome	21	16	sweep	sweep	NN
cord-264884-ydkigome	21	17	by	by	IN
cord-264884-ydkigome	21	18	retroviruses	retrovirus	NNS
cord-264884-ydkigome	21	19	that	that	WDT
cord-264884-ydkigome	21	20	infect	infect	VBP
cord-264884-ydkigome	21	21	and	and	CC
cord-264884-ydkigome	21	22	become	become	VBP
cord-264884-ydkigome	21	23	endogenized	endogenized	NNP
cord-264884-ydkigome	21	24	in	in	IN
cord-264884-ydkigome	21	25	koala	koala	NNP
cord-264884-ydkigome	21	26	bears	bear	NNS
cord-264884-ydkigome	21	27	.	.	.
cord-264884-ydkigome	22	1	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	22	2	tools	tool	NNS
cord-264884-ydkigome	22	3	have	have	VBP
cord-264884-ydkigome	22	4	greatly	greatly	RB
cord-264884-ydkigome	22	5	aided	aid	VBN
cord-264884-ydkigome	22	6	our	-PRON-	PRP$
cord-264884-ydkigome	22	7	analysis	analysis	NN
cord-264884-ydkigome	22	8	of	of	IN
cord-264884-ydkigome	22	9	virus	virus	NN
cord-264884-ydkigome	22	10	evolution	evolution	NN
cord-264884-ydkigome	22	11	,	,	,
cord-264884-ydkigome	22	12	but	but	CC
cord-264884-ydkigome	22	13	these	these	DT
cord-264884-ydkigome	22	14	methods	method	NNS
cord-264884-ydkigome	22	15	struggle	struggle	VBP
cord-264884-ydkigome	22	16	to	to	TO
cord-264884-ydkigome	22	17	characterize	characterize	VB
cord-264884-ydkigome	22	18	the	the	DT
cord-264884-ydkigome	22	19	role	role	NN
cord-264884-ydkigome	22	20	of	of	IN
cord-264884-ydkigome	22	21	virus	virus	NN
cord-264884-ydkigome	22	22	populations	population	NNS
cord-264884-ydkigome	22	23	.	.	.
cord-264884-ydkigome	23	1	Missing	miss	VBG
cord-264884-ydkigome	23	2	from	from	IN
cord-264884-ydkigome	23	3	many	many	JJ
cord-264884-ydkigome	23	4	of	of	IN
cord-264884-ydkigome	23	5	these	these	DT
cord-264884-ydkigome	23	6	considerations	consideration	NNS
cord-264884-ydkigome	23	7	has	have	VBZ
cord-264884-ydkigome	23	8	been	be	VBN
cord-264884-ydkigome	23	9	the	the	DT
cord-264884-ydkigome	23	10	major	major	JJ
cord-264884-ydkigome	23	11	role	role	NN
cord-264884-ydkigome	23	12	played	play	VBN
cord-264884-ydkigome	23	13	by	by	IN
cord-264884-ydkigome	23	14	persisting	persist	VBG
cord-264884-ydkigome	23	15	viruses	virus	NNS
cord-264884-ydkigome	23	16	in	in	IN
cord-264884-ydkigome	23	17	stable	stable	JJ
cord-264884-ydkigome	23	18	virus	virus	NN
cord-264884-ydkigome	23	19	evolution	evolution	NN
cord-264884-ydkigome	23	20	and	and	CC
cord-264884-ydkigome	23	21	disease	disease	NN
cord-264884-ydkigome	23	22	emergence	emergence	NN
cord-264884-ydkigome	23	23	.	.	.
cord-264884-ydkigome	24	1	In	in	IN
cord-264884-ydkigome	24	2	many	many	JJ
cord-264884-ydkigome	24	3	cases	case	NNS
cord-264884-ydkigome	24	4	,	,	,
cord-264884-ydkigome	24	5	extreme	extreme	JJ
cord-264884-ydkigome	24	6	stability	stability	NN
cord-264884-ydkigome	24	7	is	be	VBZ
cord-264884-ydkigome	24	8	seen	see	VBN
cord-264884-ydkigome	24	9	with	with	IN
cord-264884-ydkigome	24	10	persisting	persist	VBG
cord-264884-ydkigome	24	11	RNA	RNA	NNP
cord-264884-ydkigome	24	12	viruses	virus	NNS
cord-264884-ydkigome	24	13	.	.	.
cord-264884-ydkigome	25	1	Indeed	indeed	RB
cord-264884-ydkigome	25	2	,	,	,
cord-264884-ydkigome	25	3	examples	example	NNS
cord-264884-ydkigome	25	4	are	be	VBP
cord-264884-ydkigome	25	5	known	know	VBN
cord-264884-ydkigome	25	6	in	in	IN
cord-264884-ydkigome	25	7	which	which	WDT
cord-264884-ydkigome	25	8	it	-PRON-	PRP
cord-264884-ydkigome	25	9	is	be	VBZ
cord-264884-ydkigome	25	10	the	the	DT
cord-264884-ydkigome	25	11	persistently	persistently	RB
cord-264884-ydkigome	25	12	infected	infect	VBN
cord-264884-ydkigome	25	13	host	host	NN
cord-264884-ydkigome	25	14	that	that	WDT
cord-264884-ydkigome	25	15	has	have	VBZ
cord-264884-ydkigome	25	16	better	well	JJR
cord-264884-ydkigome	25	17	survival	survival	NN
cord-264884-ydkigome	25	18	.	.	.
cord-264884-ydkigome	26	1	We	-PRON-	PRP
cord-264884-ydkigome	26	2	have	have	VBP
cord-264884-ydkigome	26	3	also	also	RB
cord-264884-ydkigome	26	4	recently	recently	RB
cord-264884-ydkigome	26	5	come	come	VBN
cord-264884-ydkigome	26	6	to	to	TO
cord-264884-ydkigome	26	7	appreciate	appreciate	VB
cord-264884-ydkigome	26	8	the	the	DT
cord-264884-ydkigome	26	9	vast	vast	JJ
cord-264884-ydkigome	26	10	diversity	diversity	NN
cord-264884-ydkigome	26	11	of	of	IN
cord-264884-ydkigome	26	12	phage	phage	NN
cord-264884-ydkigome	26	13	(	(	-LRB-
cord-264884-ydkigome	26	14	DNA	dna	NN
cord-264884-ydkigome	26	15	viruses	virus	NNS
cord-264884-ydkigome	26	16	)	)	-RRB-
cord-264884-ydkigome	26	17	of	of	IN
cord-264884-ydkigome	26	18	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	26	19	as	as	IN
cord-264884-ydkigome	26	20	a	a	DT
cord-264884-ydkigome	26	21	system	system	NN
cord-264884-ydkigome	26	22	that	that	WDT
cord-264884-ydkigome	26	23	evolves	evolve	VBZ
cord-264884-ydkigome	26	24	by	by	IN
cord-264884-ydkigome	26	25	genetic	genetic	JJ
cord-264884-ydkigome	26	26	exchanges	exchange	NNS
cord-264884-ydkigome	26	27	across	across	IN
cord-264884-ydkigome	26	28	vast	vast	JJ
cord-264884-ydkigome	26	29	populations	population	NNS
cord-264884-ydkigome	26	30	(	(	-LRB-
cord-264884-ydkigome	26	31	Chapter	chapter	NN
cord-264884-ydkigome	26	32	10	10	CD
cord-264884-ydkigome	26	33	)	)	-RRB-
cord-264884-ydkigome	26	34	.	.	.
cord-264884-ydkigome	27	1	This	this	DT
cord-264884-ydkigome	27	2	has	have	VBZ
cord-264884-ydkigome	27	3	been	be	VBN
cord-264884-ydkigome	27	4	proposed	propose	VBN
cord-264884-ydkigome	27	5	to	to	TO
cord-264884-ydkigome	27	6	be	be	VB
cord-264884-ydkigome	27	7	the	the	DT
cord-264884-ydkigome	27	8	"	"	``
cord-264884-ydkigome	27	9	big	big	JJ
cord-264884-ydkigome	27	10	bang	bang	NN
cord-264884-ydkigome	27	11	"	"	''
cord-264884-ydkigome	27	12	of	of	IN
cord-264884-ydkigome	27	13	biological	biological	JJ
cord-264884-ydkigome	27	14	evolution	evolution	NN
cord-264884-ydkigome	27	15	.	.	.
cord-264884-ydkigome	28	1	In	in	IN
cord-264884-ydkigome	28	2	the	the	DT
cord-264884-ydkigome	28	3	large	large	JJ
cord-264884-ydkigome	28	4	DNA	dna	NN
cord-264884-ydkigome	28	5	viruses	virus	NNS
cord-264884-ydkigome	28	6	of	of	IN
cord-264884-ydkigome	28	7	aquatic	aquatic	JJ
cord-264884-ydkigome	28	8	microbes	microbe	NNS
cord-264884-ydkigome	28	9	we	-PRON-	PRP
cord-264884-ydkigome	28	10	see	see	VBP
cord-264884-ydkigome	28	11	surprisingly	surprisingly	RB
cord-264884-ydkigome	28	12	large	large	JJ
cord-264884-ydkigome	28	13	,	,	,
cord-264884-ydkigome	28	14	complex	complex	JJ
cord-264884-ydkigome	28	15	and	and	CC
cord-264884-ydkigome	28	16	diverse	diverse	JJ
cord-264884-ydkigome	28	17	viruses	virus	NNS
cord-264884-ydkigome	28	18	.	.	.
cord-264884-ydkigome	29	1	With	with	IN
cord-264884-ydkigome	29	2	both	both	DT
cord-264884-ydkigome	29	3	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	29	4	and	and	CC
cord-264884-ydkigome	29	5	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	29	6	DNA	dna	NN
cord-264884-ydkigome	29	7	viruses	virus	NNS
cord-264884-ydkigome	29	8	,	,	,
cord-264884-ydkigome	29	9	recombination	recombination	NN
cord-264884-ydkigome	29	10	is	be	VBZ
cord-264884-ydkigome	29	11	the	the	DT
cord-264884-ydkigome	29	12	main	main	JJ
cord-264884-ydkigome	29	13	engine	engine	NN
cord-264884-ydkigome	29	14	of	of	IN
cord-264884-ydkigome	29	15	virus	virus	NN
cord-264884-ydkigome	29	16	evolution	evolution	NN
cord-264884-ydkigome	29	17	,	,	,
cord-264884-ydkigome	29	18	and	and	CC
cord-264884-ydkigome	29	19	virus	virus	NN
cord-264884-ydkigome	29	20	host	host	NN
cord-264884-ydkigome	29	21	co	co	NN
cord-264884-ydkigome	29	22	-	-	NN
cord-264884-ydkigome	29	23	evolution	evolution	NN
cord-264884-ydkigome	29	24	is	be	VBZ
cord-264884-ydkigome	29	25	common	common	JJ
cord-264884-ydkigome	29	26	,	,	,
cord-264884-ydkigome	29	27	although	although	IN
cord-264884-ydkigome	29	28	not	not	RB
cord-264884-ydkigome	29	29	uniform	uniform	JJ
cord-264884-ydkigome	29	30	.	.	.
cord-264884-ydkigome	30	1	Viral	viral	JJ
cord-264884-ydkigome	30	2	emergence	emergence	NN
cord-264884-ydkigome	30	3	appears	appear	VBZ
cord-264884-ydkigome	30	4	to	to	TO
cord-264884-ydkigome	30	5	be	be	VB
cord-264884-ydkigome	30	6	an	an	DT
cord-264884-ydkigome	30	7	unending	unending	JJ
cord-264884-ydkigome	30	8	phenomenon	phenomenon	NN
cord-264884-ydkigome	30	9	and	and	CC
cord-264884-ydkigome	30	10	we	-PRON-	PRP
cord-264884-ydkigome	30	11	can	can	MD
cord-264884-ydkigome	30	12	currently	currently	RB
cord-264884-ydkigome	30	13	witness	witness	VB
cord-264884-ydkigome	30	14	a	a	DT
cord-264884-ydkigome	30	15	selective	selective	JJ
cord-264884-ydkigome	30	16	sweep	sweep	NN
cord-264884-ydkigome	30	17	by	by	IN
cord-264884-ydkigome	30	18	retroviruses	retrovirus	NNS
cord-264884-ydkigome	30	19	that	that	WDT
cord-264884-ydkigome	30	20	infect	infect	VBP
cord-264884-ydkigome	30	21	and	and	CC
cord-264884-ydkigome	30	22	become	become	VBP
cord-264884-ydkigome	30	23	endogenized	endogenized	NNP
cord-264884-ydkigome	30	24	in	in	IN
cord-264884-ydkigome	30	25	koala	koala	NNP
cord-264884-ydkigome	30	26	bears	bear	NNS
cord-264884-ydkigome	30	27	.	.	.
cord-264884-ydkigome	31	1	Our	-PRON-	PRP$
cord-264884-ydkigome	31	2	understanding	understanding	NN
cord-264884-ydkigome	31	3	of	of	IN
cord-264884-ydkigome	31	4	virus	virus	NN
cord-264884-ydkigome	31	5	evolution	evolution	NN
cord-264884-ydkigome	31	6	has	have	VBZ
cord-264884-ydkigome	31	7	reached	reach	VBN
cord-264884-ydkigome	31	8	a	a	DT
cord-264884-ydkigome	31	9	threshold	threshold	NN
cord-264884-ydkigome	31	10	in	in	IN
cord-264884-ydkigome	31	11	that	that	IN
cord-264884-ydkigome	31	12	it	-PRON-	PRP
cord-264884-ydkigome	31	13	now	now	RB
cord-264884-ydkigome	31	14	appears	appear	VBZ
cord-264884-ydkigome	31	15	to	to	TO
cord-264884-ydkigome	31	16	provide	provide	VB
cord-264884-ydkigome	31	17	a	a	DT
cord-264884-ydkigome	31	18	much	much	RB
cord-264884-ydkigome	31	19	broader	broad	JJR
cord-264884-ydkigome	31	20	vista	vista	NNS
cord-264884-ydkigome	31	21	regarding	regard	VBG
cord-264884-ydkigome	31	22	its	-PRON-	PRP$
cord-264884-ydkigome	31	23	general	general	JJ
cord-264884-ydkigome	31	24	signifi	signifi	NNP
cord-264884-ydkigome	31	25	cance	cance	NN
cord-264884-ydkigome	31	26	and	and	CC
cord-264884-ydkigome	31	27	infl	infl	NN
cord-264884-ydkigome	31	28	uence	uence	NN
cord-264884-ydkigome	31	29	on	on	IN
cord-264884-ydkigome	31	30	host	host	NN
cord-264884-ydkigome	31	31	evolution	evolution	NN
cord-264884-ydkigome	31	32	.	.	.
cord-264884-ydkigome	32	1	Several	several	JJ
cord-264884-ydkigome	32	2	developments	development	NNS
cord-264884-ydkigome	32	3	have	have	VBP
cord-264884-ydkigome	32	4	brought	bring	VBN
cord-264884-ydkigome	32	5	us	-PRON-	PRP
cord-264884-ydkigome	32	6	to	to	IN
cord-264884-ydkigome	32	7	this	this	DT
cord-264884-ydkigome	32	8	point	point	NN
cord-264884-ydkigome	32	9	.	.	.
cord-264884-ydkigome	33	1	One	one	PRP
cord-264884-ydkigome	33	2	has	have	VBZ
cord-264884-ydkigome	33	3	been	be	VBN
cord-264884-ydkigome	33	4	the	the	DT
cord-264884-ydkigome	33	5	realization	realization	NN
cord-264884-ydkigome	33	6	that	that	IN
cord-264884-ydkigome	33	7	viruses	virus	NNS
cord-264884-ydkigome	33	8	often	often	RB
cord-264884-ydkigome	33	9	evolve	evolve	VBP
cord-264884-ydkigome	33	10	by	by	IN
cord-264884-ydkigome	33	11	processes	process	NNS
cord-264884-ydkigome	33	12	involving	involve	VBG
cord-264884-ydkigome	33	13	the	the	DT
cord-264884-ydkigome	33	14	collective	collective	JJ
cord-264884-ydkigome	33	15	action	action	NN
cord-264884-ydkigome	33	16	of	of	IN
cord-264884-ydkigome	33	17	a	a	DT
cord-264884-ydkigome	33	18	consortia	consortia	NN
cord-264884-ydkigome	33	19	,	,	,
cord-264884-ydkigome	33	20	or	or	CC
cord-264884-ydkigome	33	21	quasispecies	quasispecie	NNS
cord-264884-ydkigome	33	22	.	.	.
cord-264884-ydkigome	34	1	And	and	CC
cord-264884-ydkigome	34	2	the	the	DT
cord-264884-ydkigome	34	3	resulting	result	VBG
cord-264884-ydkigome	34	4	adaptability	adaptability	NN
cord-264884-ydkigome	34	5	and	and	CC
cord-264884-ydkigome	34	6	power	power	NN
cord-264884-ydkigome	34	7	of	of	IN
cord-264884-ydkigome	34	8	such	such	JJ
cord-264884-ydkigome	34	9	evolution	evolution	NN
cord-264884-ydkigome	34	10	is	be	VBZ
cord-264884-ydkigome	34	11	unmatched	unmatched	JJ
cord-264884-ydkigome	34	12	by	by	IN
cord-264884-ydkigome	34	13	any	any	DT
cord-264884-ydkigome	34	14	other	other	JJ
cord-264884-ydkigome	34	15	genetic	genetic	JJ
cord-264884-ydkigome	34	16	entity	entity	NN
cord-264884-ydkigome	34	17	.	.	.
cord-264884-ydkigome	35	1	Much	much	JJ
cord-264884-ydkigome	35	2	of	of	IN
cord-264884-ydkigome	35	3	this	this	DT
cord-264884-ydkigome	35	4	volume	volume	NN
cord-264884-ydkigome	35	5	is	be	VBZ
cord-264884-ydkigome	35	6	dedicated	dedicate	VBN
cord-264884-ydkigome	35	7	to	to	IN
cord-264884-ydkigome	35	8	this	this	DT
cord-264884-ydkigome	35	9	issue	issue	NN
cord-264884-ydkigome	35	10	.	.	.
cord-264884-ydkigome	36	1	In	in	IN
cord-264884-ydkigome	36	2	such	such	JJ
cord-264884-ydkigome	36	3	consortia	consortium	NNS
cord-264884-ydkigome	36	4	,	,	,
cord-264884-ydkigome	36	5	the	the	DT
cord-264884-ydkigome	36	6	concept	concept	NN
cord-264884-ydkigome	36	7	of	of	IN
cord-264884-ydkigome	36	8	a	a	DT
cord-264884-ydkigome	36	9	"	"	``
cord-264884-ydkigome	36	10	wild	wild	JJ
cord-264884-ydkigome	36	11	-	-	HYPH
cord-264884-ydkigome	36	12	type	type	NN
cord-264884-ydkigome	36	13	"	"	''
cord-264884-ydkigome	36	14	virus	virus	NN
cord-264884-ydkigome	36	15	is	be	VBZ
cord-264884-ydkigome	36	16	no	no	RB
cord-264884-ydkigome	36	17	longer	long	RBR
cord-264884-ydkigome	36	18	considered	consider	VBN
cord-264884-ydkigome	36	19	to	to	TO
cord-264884-ydkigome	36	20	be	be	VB
cord-264884-ydkigome	36	21	the	the	DT
cord-264884-ydkigome	36	22	fi	fi	NN
cord-264884-ydkigome	36	23	ttest	ttest	NN
cord-264884-ydkigome	36	24	type	type	NN
cord-264884-ydkigome	36	25	,	,	,
cord-264884-ydkigome	36	26	as	as	IN
cord-264884-ydkigome	36	27	the	the	DT
cord-264884-ydkigome	36	28	quasispecies	quasispecie	NNS
cord-264884-ydkigome	36	29	itself	-PRON-	PRP
cord-264884-ydkigome	36	30	provides	provide	VBZ
cord-264884-ydkigome	36	31	fi	fi	NNP
cord-264884-ydkigome	36	32	tness	tness	NN
cord-264884-ydkigome	36	33	(	(	-LRB-
cord-264884-ydkigome	36	34	see	see	VB
cord-264884-ydkigome	36	35	Chapters	chapter	NNS
cord-264884-ydkigome	36	36	3	3	CD
cord-264884-ydkigome	36	37	and	and	CC
cord-264884-ydkigome	36	38	4	4	CD
cord-264884-ydkigome	36	39	)	)	-RRB-
cord-264884-ydkigome	36	40	.	.	.
cord-264884-ydkigome	37	1	The	the	DT
cord-264884-ydkigome	37	2	quasispecies	quasispecie	NNS
cord-264884-ydkigome	37	3	model	model	NN
cord-264884-ydkigome	37	4	resembles	resemble	VBZ
cord-264884-ydkigome	37	5	population	population	NN
cord-264884-ydkigome	37	6	genetics	genetic	NNS
cord-264884-ydkigome	37	7	in	in	IN
cord-264884-ydkigome	37	8	some	some	DT
cord-264884-ydkigome	37	9	ways	way	NNS
cord-264884-ydkigome	37	10	,	,	,
cord-264884-ydkigome	37	11	but	but	CC
cord-264884-ydkigome	37	12	it	-PRON-	PRP
cord-264884-ydkigome	37	13	has	have	VBZ
cord-264884-ydkigome	37	14	led	lead	VBN
cord-264884-ydkigome	37	15	to	to	IN
cord-264884-ydkigome	37	16	some	some	DT
cord-264884-ydkigome	37	17	signifi	signifi	NN
cord-264884-ydkigome	37	18	ca	can	MD
cord-264884-ydkigome	37	19	nt	not	RB
cord-264884-ydkigome	37	20	departures	departure	NNS
cord-264884-ydkigome	37	21	from	from	IN
cord-264884-ydkigome	37	22	population	population	NN
cord-264884-ydkigome	37	23	genetics	genetic	NNS
cord-264884-ydkigome	37	24	,	,	,
cord-264884-ydkigome	37	25	and	and	CC
cord-264884-ydkigome	37	26	these	these	DT
cord-264884-ydkigome	37	27	departures	departure	NNS
cord-264884-ydkigome	37	28	are	be	VBP
cord-264884-ydkigome	37	29	very	very	RB
cord-264884-ydkigome	37	30	well	well	RB
cord-264884-ydkigome	37	31	supported	support	VBN
cord-264884-ydkigome	37	32	by	by	IN
cord-264884-ydkigome	37	33	experiments	experiment	NNS
cord-264884-ydkigome	37	34	.	.	.
cord-264884-ydkigome	38	1	Another	another	DT
cord-264884-ydkigome	38	2	development	development	NN
cord-264884-ydkigome	38	3	that	that	WDT
cord-264884-ydkigome	38	4	has	have	VBZ
cord-264884-ydkigome	38	5	recalibrated	recalibrate	VBN
cord-264884-ydkigome	38	6	our	-PRON-	PRP$
cord-264884-ydkigome	38	7	view	view	NN
cord-264884-ydkigome	38	8	of	of	IN
cord-264884-ydkigome	38	9	the	the	DT
cord-264884-ydkigome	38	10	overall	overall	JJ
cord-264884-ydkigome	38	11	signifi	signifi	NNP
cord-264884-ydkigome	38	12	cance	cance	NN
cord-264884-ydkigome	38	13	of	of	IN
cord-264884-ydkigome	38	14	viruses	virus	NNS
cord-264884-ydkigome	38	15	is	be	VBZ
cord-264884-ydkigome	38	16	information	information	NN
cord-264884-ydkigome	38	17	on	on	IN
cord-264884-ydkigome	38	18	the	the	DT
cord-264884-ydkigome	38	19	scale	scale	NN
cord-264884-ydkigome	38	20	and	and	CC
cord-264884-ydkigome	38	21	diversity	diversity	NN
cord-264884-ydkigome	38	22	of	of	IN
cord-264884-ydkigome	38	23	viruses	virus	NNS
cord-264884-ydkigome	38	24	.	.	.
cord-264884-ydkigome	39	1	Viruses	virus	NNS
cord-264884-ydkigome	39	2	are	be	VBP
cord-264884-ydkigome	39	3	present	present	JJ
cord-264884-ydkigome	39	4	at	at	IN
cord-264884-ydkigome	39	5	a	a	DT
cord-264884-ydkigome	39	6	previously	previously	RB
cord-264884-ydkigome	39	7	unappreciated	unappreciate	VBN
cord-264884-ydkigome	39	8	global	global	JJ
cord-264884-ydkigome	39	9	level	level	NN
cord-264884-ydkigome	39	10	and	and	CC
cord-264884-ydkigome	39	11	appear	appear	VBP
cord-264884-ydkigome	39	12	to	to	TO
cord-264884-ydkigome	39	13	have	have	VB
cord-264884-ydkigome	39	14	affected	affect	VBN
cord-264884-ydkigome	39	15	the	the	DT
cord-264884-ydkigome	39	16	evolution	evolution	NN
cord-264884-ydkigome	39	17	of	of	IN
cord-264884-ydkigome	39	18	all	all	DT
cord-264884-ydkigome	39	19	life	life	NN
cord-264884-ydkigome	39	20	on	on	IN
cord-264884-ydkigome	39	21	Earth	Earth	NNP
cord-264884-ydkigome	39	22	.	.	.
cord-264884-ydkigome	40	1	Much	much	JJ
cord-264884-ydkigome	40	2	of	of	IN
cord-264884-ydkigome	40	3	this	this	DT
cord-264884-ydkigome	40	4	realization	realization	NN
cord-264884-ydkigome	40	5	has	have	VBZ
cord-264884-ydkigome	40	6	been	be	VBN
cord-264884-ydkigome	40	7	brought	bring	VBN
cord-264884-ydkigome	40	8	about	about	RP
cord-264884-ydkigome	40	9	by	by	IN
cord-264884-ydkigome	40	10	the	the	DT
cord-264884-ydkigome	40	11	development	development	NN
cord-264884-ydkigome	40	12	of	of	IN
cord-264884-ydkigome	40	13	metagenomic	metagenomic	NNP
cord-264884-ydkigome	40	14	methods	method	NNS
cord-264884-ydkigome	40	15	as	as	IN
cord-264884-ydkigome	40	16	applied	apply	VBN
cord-264884-ydkigome	40	17	to	to	IN
cord-264884-ydkigome	40	18	various	various	JJ
cord-264884-ydkigome	40	19	habitats	habitat	NNS
cord-264884-ydkigome	40	20	.	.	.
cord-264884-ydkigome	41	1	Measurements	measurement	NNS
cord-264884-ydkigome	41	2	of	of	IN
cord-264884-ydkigome	41	3	major	major	JJ
cord-264884-ydkigome	41	4	habitats	habitat	NNS
cord-264884-ydkigome	41	5	(	(	-LRB-
cord-264884-ydkigome	41	6	the	the	DT
cord-264884-ydkigome	41	7	oceans	ocean	NNS
cord-264884-ydkigome	41	8	,	,	,
cord-264884-ydkigome	41	9	soil	soil	NN
cord-264884-ydkigome	41	10	,	,	,
cord-264884-ydkigome	41	11	extreme	extreme	JJ
cord-264884-ydkigome	41	12	environments	environment	NNS
cord-264884-ydkigome	41	13	)	)	-RRB-
cord-264884-ydkigome	41	14	have	have	VBP
cord-264884-ydkigome	41	15	established	establish	VBN
cord-264884-ydkigome	41	16	that	that	IN
cord-264884-ydkigome	41	17	our	-PRON-	PRP$
cord-264884-ydkigome	41	18	biological	biological	JJ
cord-264884-ydkigome	41	19	world	world	NN
cord-264884-ydkigome	41	20	is	be	VBZ
cord-264884-ydkigome	41	21	predominantly	predominantly	RB
cord-264884-ydkigome	41	22	viral	viral	JJ
cord-264884-ydkigome	41	23	,	,	,
cord-264884-ydkigome	41	24	in	in	IN
cord-264884-ydkigome	41	25	terms	term	NNS
cord-264884-ydkigome	41	26	of	of	IN
cord-264884-ydkigome	41	27	both	both	DT
cord-264884-ydkigome	41	28	numbers	number	NNS
cord-264884-ydkigome	41	29	and	and	CC
cord-264884-ydkigome	41	30	diversity	diversity	NN
cord-264884-ydkigome	42	1	(	(	-LRB-
cord-264884-ydkigome	42	2	Paul	Paul	NNP
cord-264884-ydkigome	42	3	et	et	NNP
cord-264884-ydkigome	42	4	al	al	NNP
cord-264884-ydkigome	42	5	.	.	NNP
cord-264884-ydkigome	42	6	,	,	,
cord-264884-ydkigome	42	7	2002	2002	CD
cord-264884-ydkigome	43	1	;	;	:
cord-264884-ydkigome	43	2	Breitbart	Breitbart	NNP
cord-264884-ydkigome	43	3	et	et	NNP
cord-264884-ydkigome	43	4	al	al	NNP
cord-264884-ydkigome	43	5	.	.	NNP
cord-264884-ydkigome	43	6	,	,	,
cord-264884-ydkigome	43	7	2003	2003	CD
cord-264884-ydkigome	43	8	;	;	:
cord-264884-ydkigome	43	9	Rohwer	Rohwer	NNP
cord-264884-ydkigome	43	10	,	,	,
cord-264884-ydkigome	43	11	2005a	2005a	CD
cord-264884-ydkigome	43	12	,	,	,
cord-264884-ydkigome	43	13	2005b	2005b	CD
cord-264884-ydkigome	43	14	;	;	:
cord-264884-ydkigome	43	15	Edwards	Edwards	NNP
cord-264884-ydkigome	43	16	and	and	CC
cord-264884-ydkigome	43	17	Rohwer	Rohwer	NNP
cord-264884-ydkigome	43	18	,	,	,
cord-264884-ydkigome	43	19	2005	2005	CD
cord-264884-ydkigome	43	20	;	;	:
cord-264884-ydkigome	43	21	Comeau	Comeau	NNP
cord-264884-ydkigome	43	22	et	et	NNP
cord-264884-ydkigome	43	23	al	al	NNP
cord-264884-ydkigome	43	24	.	.	NNP
cord-264884-ydkigome	43	25	,	,	,
cord-264884-ydkigome	43	26	2006	2006	CD
cord-264884-ydkigome	43	27	)	)	-RRB-
cord-264884-ydkigome	43	28	.	.	.
cord-264884-ydkigome	44	1	These	these	DT
cord-264884-ydkigome	44	2	two	two	CD
cord-264884-ydkigome	44	3	developments	development	NNS
cord-264884-ydkigome	44	4	would	would	MD
cord-264884-ydkigome	44	5	seem	seem	VB
cord-264884-ydkigome	44	6	reason	reason	NN
cord-264884-ydkigome	44	7	enough	enough	JJ
cord-264884-ydkigome	44	8	to	to	TO
cord-264884-ydkigome	44	9	consider	consider	VB
cord-264884-ydkigome	44	10	virus	virus	NN
cord-264884-ydkigome	44	11	evolution	evolution	NN
cord-264884-ydkigome	44	12	in	in	IN
cord-264884-ydkigome	44	13	a	a	DT
cord-264884-ydkigome	44	14	new	new	JJ
cord-264884-ydkigome	44	15	light	light	NN
cord-264884-ydkigome	44	16	.	.	.
cord-264884-ydkigome	45	1	However	however	RB
cord-264884-ydkigome	45	2	,	,	,
cord-264884-ydkigome	45	3	there	there	EX
cord-264884-ydkigome	45	4	have	have	VBP
cord-264884-ydkigome	45	5	also	also	RB
cord-264884-ydkigome	45	6	been	be	VBN
cord-264884-ydkigome	45	7	numerous	numerous	JJ
cord-264884-ydkigome	45	8	theoretical	theoretical	JJ
cord-264884-ydkigome	45	9	proposals	proposal	NNS
cord-264884-ydkigome	45	10	suggesting	suggest	VBG
cord-264884-ydkigome	45	11	viral	viral	JJ
cord-264884-ydkigome	45	12	involvement	involvement	NN
cord-264884-ydkigome	45	13	in	in	IN
cord-264884-ydkigome	45	14	some	some	DT
cord-264884-ydkigome	45	15	of	of	IN
cord-264884-ydkigome	45	16	the	the	DT
cord-264884-ydkigome	45	17	very	very	RB
cord-264884-ydkigome	45	18	earliest	early	JJS
cord-264884-ydkigome	45	19	events	event	NNS
cord-264884-ydkigome	45	20	and	and	CC
cord-264884-ydkigome	45	21	major	major	JJ
cord-264884-ydkigome	45	22	transitions	transition	NNS
cord-264884-ydkigome	45	23	in	in	IN
cord-264884-ydkigome	45	24	the	the	DT
cord-264884-ydkigome	45	25	evolution	evolution	NN
cord-264884-ydkigome	45	26	of	of	IN
cord-264884-ydkigome	45	27	life	life	NN
cord-264884-ydkigome	45	28	.	.	.
cord-264884-ydkigome	46	1	We	-PRON-	PRP
cord-264884-ydkigome	46	2	no	no	RB
cord-264884-ydkigome	46	3	longer	longer	RB
cord-264884-ydkigome	46	4	think	think	VBP
cord-264884-ydkigome	46	5	of	of	IN
cord-264884-ydkigome	46	6	viruses	virus	NNS
cord-264884-ydkigome	46	7	as	as	IN
cord-264884-ydkigome	46	8	recent	recent	JJ
cord-264884-ydkigome	46	9	agents	agent	NNS
cord-264884-ydkigome	46	10	that	that	WDT
cord-264884-ydkigome	46	11	escaped	escape	VBD
cord-264884-ydkigome	46	12	from	from	IN
cord-264884-ydkigome	46	13	the	the	DT
cord-264884-ydkigome	46	14	host	host	NN
cord-264884-ydkigome	46	15	chromosomes	chromosome	NNS
cord-264884-ydkigome	46	16	as	as	IN
cord-264884-ydkigome	46	17	run	run	VBN
cord-264884-ydkigome	46	18	away	away	RB
cord-264884-ydkigome	46	19	replicons	replicon	NNS
cord-264884-ydkigome	46	20	.	.	.
cord-264884-ydkigome	47	1	Viruses	virus	NNS
cord-264884-ydkigome	47	2	now	now	RB
cord-264884-ydkigome	47	3	appear	appear	VBP
cord-264884-ydkigome	47	4	very	very	RB
cord-264884-ydkigome	47	5	old	old	JJ
cord-264884-ydkigome	47	6	to	to	IN
cord-264884-ydkigome	47	7	us	-PRON-	PRP
cord-264884-ydkigome	48	1	and	and	CC
cord-264884-ydkigome	48	2	they	-PRON-	PRP
cord-264884-ydkigome	48	3	relate	relate	VBP
cord-264884-ydkigome	48	4	to	to	IN
cord-264884-ydkigome	48	5	and	and	CC
cord-264884-ydkigome	48	6	trace	trace	VB
cord-264884-ydkigome	48	7	all	all	DT
cord-264884-ydkigome	48	8	branches	branch	NNS
cord-264884-ydkigome	48	9	of	of	IN
cord-264884-ydkigome	48	10	life	life	NN
cord-264884-ydkigome	48	11	.	.	.
cord-264884-ydkigome	49	1	The	the	DT
cord-264884-ydkigome	49	2	last	last	JJ
cord-264884-ydkigome	49	3	30	30	CD
cord-264884-ydkigome	49	4	years	year	NNS
cord-264884-ydkigome	49	5	have	have	VBP
cord-264884-ydkigome	49	6	been	be	VBN
cord-264884-ydkigome	49	7	very	very	RB
cord-264884-ydkigome	49	8	active	active	JJ
cord-264884-ydkigome	49	9	regarding	regard	VBG
cord-264884-ydkigome	49	10	virus	virus	NN
cord-264884-ydkigome	49	11	evolution	evolution	NN
cord-264884-ydkigome	49	12	.	.	.
cord-264884-ydkigome	50	1	Major	major	JJ
cord-264884-ydkigome	50	2	developments	development	NNS
cord-264884-ydkigome	50	3	in	in	IN
cord-264884-ydkigome	50	4	theory	theory	NN
cord-264884-ydkigome	50	5	,	,	,
cord-264884-ydkigome	50	6	technology	technology	NN
cord-264884-ydkigome	50	7	,	,	,
cord-264884-ydkigome	50	8	medicine	medicine	NN
cord-264884-ydkigome	50	9	,	,	,
cord-264884-ydkigome	50	10	and	and	CC
cord-264884-ydkigome	50	11	the	the	DT
cord-264884-ydkigome	50	12	study	study	NN
cord-264884-ydkigome	50	13	of	of	IN
cord-264884-ydkigome	50	14	human	human	JJ
cord-264884-ydkigome	50	15	disease	disease	NN
cord-264884-ydkigome	50	16	with	with	IN
cord-264884-ydkigome	50	17	respect	respect	NN
cord-264884-ydkigome	50	18	to	to	IN
cord-264884-ydkigome	50	19	virus	virus	NN
cord-264884-ydkigome	50	20	evolution	evolution	NN
cord-264884-ydkigome	50	21	have	have	VBP
cord-264884-ydkigome	50	22	all	all	RB
cord-264884-ydkigome	50	23	occurred	occur	VBN
cord-264884-ydkigome	50	24	.	.	.
cord-264884-ydkigome	51	1	And	and	CC
cord-264884-ydkigome	51	2	as	as	IN
cord-264884-ydkigome	51	3	we	-PRON-	PRP
cord-264884-ydkigome	51	4	seek	seek	VBP
cord-264884-ydkigome	51	5	to	to	TO
cord-264884-ydkigome	51	6	grow	grow	VB
cord-264884-ydkigome	51	7	and	and	CC
cord-264884-ydkigome	51	8	manage	manage	VB
cord-264884-ydkigome	51	9	various	various	JJ
cord-264884-ydkigome	51	10	life	life	NN
cord-264884-ydkigome	51	11	forms	form	NNS
cord-264884-ydkigome	51	12	for	for	IN
cord-264884-ydkigome	51	13	human	human	JJ
cord-264884-ydkigome	51	14	use	use	NN
cord-264884-ydkigome	51	15	,	,	,
cord-264884-ydkigome	51	16	virus	virus	NN
cord-264884-ydkigome	51	17	evolution	evolution	NN
cord-264884-ydkigome	51	18	has	have	VBZ
cord-264884-ydkigome	51	19	also	also	RB
cord-264884-ydkigome	51	20	had	have	VBN
cord-264884-ydkigome	51	21	major	major	JJ
cord-264884-ydkigome	51	22	impact	impact	NN
cord-264884-ydkigome	51	23	on	on	IN
cord-264884-ydkigome	51	24	such	such	JJ
cord-264884-ydkigome	51	25	efforts	effort	NNS
cord-264884-ydkigome	51	26	.	.	.
cord-264884-ydkigome	52	1	As	as	IN
cord-264884-ydkigome	52	2	a	a	DT
cord-264884-ydkigome	52	3	science	science	NN
cord-264884-ydkigome	52	4	,	,	,
cord-264884-ydkigome	52	5	virus	virus	NN
cord-264884-ydkigome	52	6	evolution	evolution	NN
cord-264884-ydkigome	52	7	has	have	VBZ
cord-264884-ydkigome	52	8	benefi	benefi	NNP
cord-264884-ydkigome	52	9	tted	tte	VBN
cord-264884-ydkigome	52	10	greatly	greatly	RB
cord-264884-ydkigome	52	11	from	from	IN
cord-264884-ydkigome	52	12	traditional	traditional	JJ
cord-264884-ydkigome	52	13	evolutionary	evolutionary	JJ
cord-264884-ydkigome	52	14	biology	biology	NN
cord-264884-ydkigome	52	15	.	.	.
cord-264884-ydkigome	53	1	However	however	RB
cord-264884-ydkigome	53	2	,	,	,
cord-264884-ydkigome	53	3	since	since	IN
cord-264884-ydkigome	53	4	viruses	virus	NNS
cord-264884-ydkigome	53	5	are	be	VBP
cord-264884-ydkigome	53	6	molecular	molecular	JJ
cord-264884-ydkigome	53	7	genetic	genetic	JJ
cord-264884-ydkigome	53	8	parasites	parasite	NNS
cord-264884-ydkigome	53	9	that	that	WDT
cord-264884-ydkigome	53	10	are	be	VBP
cord-264884-ydkigome	53	11	inscrutable	inscrutable	JJ
cord-264884-ydkigome	53	12	by	by	IN
cord-264884-ydkigome	53	13	casual	casual	JJ
cord-264884-ydkigome	53	14	observation	observation	NN
cord-264884-ydkigome	53	15	,	,	,
cord-264884-ydkigome	53	16	our	-PRON-	PRP$
cord-264884-ydkigome	53	17	understanding	understanding	NN
cord-264884-ydkigome	53	18	of	of	IN
cord-264884-ydkigome	53	19	virus	virus	NN
cord-264884-ydkigome	53	20	evolution	evolution	NN
cord-264884-ydkigome	53	21	has	have	VBZ
cord-264884-ydkigome	53	22	been	be	VBN
cord-264884-ydkigome	53	23	dependent	dependent	JJ
cord-264884-ydkigome	53	24	upon	upon	IN
cord-264884-ydkigome	53	25	measuring	measure	VBG
cord-264884-ydkigome	53	26	sequence	sequence	NN
cord-264884-ydkigome	53	27	variation	variation	NN
cord-264884-ydkigome	53	28	and	and	CC
cord-264884-ydkigome	53	29	sequence	sequence	NN
cord-264884-ydkigome	53	30	diversity	diversity	NN
cord-264884-ydkigome	53	31	in	in	IN
cord-264884-ydkigome	53	32	a	a	DT
cord-264884-ydkigome	53	33	large	large	JJ
cord-264884-ydkigome	53	34	number	number	NN
cord-264884-ydkigome	53	35	of	of	IN
cord-264884-ydkigome	53	36	virus	virus	NN
cord-264884-ydkigome	53	37	genomes	genome	NNS
cord-264884-ydkigome	53	38	.	.	.
cord-264884-ydkigome	54	1	Because	because	IN
cord-264884-ydkigome	54	2	of	of	IN
cord-264884-ydkigome	54	3	this	this	DT
cord-264884-ydkigome	54	4	,	,	,
cord-264884-ydkigome	54	5	these	these	DT
cord-264884-ydkigome	54	6	small	small	JJ
cord-264884-ydkigome	54	7	genetic	genetic	JJ
cord-264884-ydkigome	54	8	parasites	parasite	NNS
cord-264884-ydkigome	54	9	have	have	VBP
cord-264884-ydkigome	54	10	been	be	VBN
cord-264884-ydkigome	54	11	the	the	DT
cord-264884-ydkigome	54	12	last	last	JJ
cord-264884-ydkigome	54	13	domain	domain	NN
cord-264884-ydkigome	54	14	of	of	IN
cord-264884-ydkigome	54	15	life	life	NN
cord-264884-ydkigome	54	16	to	to	TO
cord-264884-ydkigome	54	17	yield	yield	VB
cord-264884-ydkigome	54	18	their	-PRON-	PRP$
cord-264884-ydkigome	54	19	secrets	secret	NNS
cord-264884-ydkigome	54	20	of	of	IN
cord-264884-ydkigome	54	21	evolution	evolution	NN
cord-264884-ydkigome	54	22	.	.	.
cord-264884-ydkigome	55	1	And	and	CC
cord-264884-ydkigome	55	2	viruses	virus	NNS
cord-264884-ydkigome	55	3	harbor	harbor	VBP
cord-264884-ydkigome	55	4	some	some	DT
cord-264884-ydkigome	55	5	clearly	clearly	RB
cord-264884-ydkigome	55	6	distinct	distinct	JJ
cord-264884-ydkigome	55	7	evolutionary	evolutionary	JJ
cord-264884-ydkigome	55	8	abilities	ability	NNS
cord-264884-ydkigome	55	9	.	.	.
cord-264884-ydkigome	56	1	For	for	IN
cord-264884-ydkigome	56	2	one	one	CD
cord-264884-ydkigome	56	3	,	,	,
cord-264884-ydkigome	56	4	they	-PRON-	PRP
cord-264884-ydkigome	56	5	are	be	VBP
cord-264884-ydkigome	56	6	polyphyletic	polyphyletic	JJ
cord-264884-ydkigome	56	7	.	.	.
cord-264884-ydkigome	57	1	All	all	DT
cord-264884-ydkigome	57	2	major	major	JJ
cord-264884-ydkigome	57	3	viral	viral	JJ
cord-264884-ydkigome	57	4	lineages	lineage	NNS
cord-264884-ydkigome	57	5	have	have	VBP
cord-264884-ydkigome	57	6	their	-PRON-	PRP$
cord-264884-ydkigome	57	7	own	own	JJ
cord-264884-ydkigome	57	8	distinct	distinct	JJ
cord-264884-ydkigome	57	9	origins	origin	NNS
cord-264884-ydkigome	57	10	.	.	.
cord-264884-ydkigome	58	1	They	-PRON-	PRP
cord-264884-ydkigome	58	2	are	be	VBP
cord-264884-ydkigome	58	3	also	also	RB
cord-264884-ydkigome	58	4	difficult	difficult	JJ
cord-264884-ydkigome	58	5	if	if	IN
cord-264884-ydkigome	58	6	not	not	RB
cord-264884-ydkigome	58	7	impossible	impossible	JJ
cord-264884-ydkigome	58	8	to	to	TO
cord-264884-ydkigome	58	9	defi	defi	NNP
cord-264884-ydkigome	58	10	ne	ne	NNP
cord-264884-ydkigome	58	11	as	as	IN
cord-264884-ydkigome	58	12	species	specie	NNS
cord-264884-ydkigome	58	13	and	and	CC
cord-264884-ydkigome	58	14	are	be	VBP
cord-264884-ydkigome	58	15	able	able	JJ
cord-264884-ydkigome	58	16	to	to	TO
cord-264884-ydkigome	58	17	exchange	exchange	VB
cord-264884-ydkigome	58	18	genetic	genetic	JJ
cord-264884-ydkigome	58	19	information	information	NN
cord-264884-ydkigome	58	20	across	across	IN
cord-264884-ydkigome	58	21	normal	normal	JJ
cord-264884-ydkigome	58	22	boundaries	boundary	NNS
cord-264884-ydkigome	58	23	.	.	.
cord-264884-ydkigome	59	1	Even	even	RB
cord-264884-ydkigome	59	2	"	"	``
cord-264884-ydkigome	59	3	dead	dead	JJ
cord-264884-ydkigome	59	4	"	"	''
cord-264884-ydkigome	59	5	and	and	CC
cord-264884-ydkigome	59	6	defective	defective	JJ
cord-264884-ydkigome	59	7	viruses	virus	NNS
cord-264884-ydkigome	59	8	can	can	MD
cord-264884-ydkigome	59	9	participate	participate	VB
cord-264884-ydkigome	59	10	in	in	IN
cord-264884-ydkigome	59	11	such	such	JJ
cord-264884-ydkigome	59	12	exchanges	exchange	NNS
cord-264884-ydkigome	59	13	,	,	,
cord-264884-ydkigome	59	14	which	which	WDT
cord-264884-ydkigome	59	15	confuses	confuse	VBZ
cord-264884-ydkigome	59	16	the	the	DT
cord-264884-ydkigome	59	17	defi	defi	NNP
cord-264884-ydkigome	59	18	nitions	nition	NNS
cord-264884-ydkigome	59	19	of	of	IN
cord-264884-ydkigome	59	20	fi	fi	NNP
cord-264884-ydkigome	59	21	tness	tness	NNP
cord-264884-ydkigome	59	22	.	.	.
cord-264884-ydkigome	60	1	We	-PRON-	PRP
cord-264884-ydkigome	60	2	now	now	RB
cord-264884-ydkigome	60	3	know	know	VBP
cord-264884-ydkigome	60	4	that	that	IN
cord-264884-ydkigome	60	5	viruses	virus	NNS
cord-264884-ydkigome	60	6	can	can	MD
cord-264884-ydkigome	60	7	evolve	evolve	VB
cord-264884-ydkigome	60	8	by	by	IN
cord-264884-ydkigome	60	9	a	a	DT
cord-264884-ydkigome	60	10	consortia	consortia	NN
cord-264884-ydkigome	60	11	process	process	NN
cord-264884-ydkigome	60	12	and	and	CC
cord-264884-ydkigome	60	13	also	also	RB
cord-264884-ydkigome	60	14	exchange	exchange	VB
cord-264884-ydkigome	60	15	information	information	NN
cord-264884-ydkigome	60	16	by	by	IN
cord-264884-ydkigome	60	17	recombination	recombination	NN
cord-264884-ydkigome	60	18	across	across	IN
cord-264884-ydkigome	60	19	vast	vast	JJ
cord-264884-ydkigome	60	20	genetic	genetic	JJ
cord-264884-ydkigome	60	21	pools	pool	NNS
cord-264884-ydkigome	60	22	to	to	TO
cord-264884-ydkigome	60	23	assemble	assemble	VB
cord-264884-ydkigome	60	24	new	new	JJ
cord-264884-ydkigome	60	25	mosaic	mosaic	JJ
cord-264884-ydkigome	60	26	combinations	combination	NNS
cord-264884-ydkigome	60	27	of	of	IN
cord-264884-ydkigome	60	28	genes	gene	NNS
cord-264884-ydkigome	60	29	.	.	.
cord-264884-ydkigome	61	1	We	-PRON-	PRP
cord-264884-ydkigome	61	2	thus	thus	RB
cord-264884-ydkigome	61	3	no	no	RB
cord-264884-ydkigome	61	4	longer	longer	RB
cord-264884-ydkigome	61	5	think	think	VBP
cord-264884-ydkigome	61	6	of	of	IN
cord-264884-ydkigome	61	7	a	a	DT
cord-264884-ydkigome	61	8	specifi	specifi	NN
cord-264884-ydkigome	61	9	c	c	NN
cord-264884-ydkigome	61	10	genetic	genetic	JJ
cord-264884-ydkigome	61	11	lineage	lineage	NN
cord-264884-ydkigome	61	12	in	in	IN
cord-264884-ydkigome	61	13	understanding	understand	VBG
cord-264884-ydkigome	61	14	virus	virus	NN
cord-264884-ydkigome	61	15	evolution	evolution	NN
cord-264884-ydkigome	61	16	,	,	,
cord-264884-ydkigome	61	17	but	but	CC
cord-264884-ydkigome	61	18	instead	instead	RB
cord-264884-ydkigome	61	19	think	think	VBP
cord-264884-ydkigome	61	20	of	of	IN
cord-264884-ydkigome	61	21	a	a	DT
cord-264884-ydkigome	61	22	cloud	cloud	NN
cord-264884-ydkigome	61	23	,	,	,
cord-264884-ydkigome	61	24	matrix	matrix	NN
cord-264884-ydkigome	61	25	,	,	,
cord-264884-ydkigome	61	26	or	or	CC
cord-264884-ydkigome	61	27	a	a	DT
cord-264884-ydkigome	61	28	population	population	NN
cord-264884-ydkigome	61	29	as	as	IN
cord-264884-ydkigome	61	30	the	the	DT
cord-264884-ydkigome	61	31	basis	basis	NN
cord-264884-ydkigome	61	32	of	of	IN
cord-264884-ydkigome	61	33	virus	virus	NN
cord-264884-ydkigome	61	34	evolution	evolution	NN
cord-264884-ydkigome	61	35	.	.	.
cord-264884-ydkigome	62	1	Viruses	virus	NNS
cord-264884-ydkigome	62	2	are	be	VBP
cord-264884-ydkigome	62	3	inherently	inherently	RB
cord-264884-ydkigome	62	4	fuzzy	fuzzy	JJ
cord-264884-ydkigome	62	5	entities	entity	NNS
cord-264884-ydkigome	62	6	that	that	WDT
cord-264884-ydkigome	62	7	can	can	MD
cord-264884-ydkigome	62	8	differ	differ	VB
cord-264884-ydkigome	62	9	from	from	IN
cord-264884-ydkigome	62	10	their	-PRON-	PRP$
cord-264884-ydkigome	62	11	relatives	relative	NNS
cord-264884-ydkigome	62	12	in	in	IN
cord-264884-ydkigome	62	13	any	any	DT
cord-264884-ydkigome	62	14	specifi	specifi	NN
cord-264884-ydkigome	62	15	c	c	NN
cord-264884-ydkigome	62	16	feature	feature	NN
cord-264884-ydkigome	62	17	.	.	.
cord-264884-ydkigome	63	1	Yet	yet	CC
cord-264884-ydkigome	63	2	even	even	RB
cord-264884-ydkigome	63	3	with	with	IN
cord-264884-ydkigome	63	4	such	such	JJ
cord-264884-ydkigome	63	5	fuzziness	fuzziness	NN
cord-264884-ydkigome	63	6	,	,	,
cord-264884-ydkigome	63	7	it	-PRON-	PRP
cord-264884-ydkigome	63	8	is	be	VBZ
cord-264884-ydkigome	63	9	clear	clear	JJ
cord-264884-ydkigome	63	10	that	that	IN
cord-264884-ydkigome	63	11	common	common	JJ
cord-264884-ydkigome	63	12	themes	theme	NNS
cord-264884-ydkigome	63	13	also	also	RB
cord-264884-ydkigome	63	14	link	link	VBP
cord-264884-ydkigome	63	15	them	-PRON-	PRP
cord-264884-ydkigome	63	16	.	.	.
cord-264884-ydkigome	64	1	Patterns	pattern	NNS
cord-264884-ydkigome	64	2	of	of	IN
cord-264884-ydkigome	64	3	evolution	evolution	NN
cord-264884-ydkigome	64	4	have	have	VBP
cord-264884-ydkigome	64	5	become	become	VBN
cord-264884-ydkigome	64	6	clear	clear	JJ
cord-264884-ydkigome	64	7	.	.	.
cord-264884-ydkigome	65	1	Diversity	diversity	NN
cord-264884-ydkigome	65	2	and	and	CC
cord-264884-ydkigome	65	3	variation	variation	NN
cord-264884-ydkigome	65	4	are	be	VBP
cord-264884-ydkigome	65	5	often	often	RB
cord-264884-ydkigome	65	6	(	(	-LRB-
cord-264884-ydkigome	65	7	but	but	CC
cord-264884-ydkigome	65	8	not	not	RB
cord-264884-ydkigome	65	9	always	always	RB
cord-264884-ydkigome	65	10	)	)	-RRB-
cord-264884-ydkigome	65	11	observed	observe	VBN
cord-264884-ydkigome	65	12	.	.	.
cord-264884-ydkigome	66	1	Stability	stability	NN
cord-264884-ydkigome	66	2	and	and	CC
cord-264884-ydkigome	66	3	host	host	NN
cord-264884-ydkigome	66	4	congruence	congruence	NN
cord-264884-ydkigome	66	5	can	can	MD
cord-264884-ydkigome	66	6	also	also	RB
cord-264884-ydkigome	66	7	be	be	VB
cord-264884-ydkigome	66	8	observed	observe	VBN
cord-264884-ydkigome	66	9	.	.	.
cord-264884-ydkigome	67	1	Nevertheless	nevertheless	RB
cord-264884-ydkigome	67	2	,	,	,
cord-264884-ydkigome	67	3	the	the	DT
cord-264884-ydkigome	67	4	evolutionary	evolutionary	JJ
cord-264884-ydkigome	67	5	power	power	NN
cord-264884-ydkigome	67	6	of	of	IN
cord-264884-ydkigome	67	7	viruses	virus	NNS
cord-264884-ydkigome	67	8	has	have	VBZ
cord-264884-ydkigome	67	9	been	be	VBN
cord-264884-ydkigome	67	10	learned	learn	VBN
cord-264884-ydkigome	67	11	at	at	IN
cord-264884-ydkigome	67	12	a	a	DT
cord-264884-ydkigome	67	13	human	human	JJ
cord-264884-ydkigome	67	14	cost	cost	NN
cord-264884-ydkigome	67	15	.	.	.
cord-264884-ydkigome	68	1	The	the	DT
cord-264884-ydkigome	68	2	application	application	NN
cord-264884-ydkigome	68	3	of	of	IN
cord-264884-ydkigome	68	4	numerous	numerous	JJ
cord-264884-ydkigome	68	5	analytical	analytical	JJ
cord-264884-ydkigome	68	6	and	and	CC
cord-264884-ydkigome	68	7	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	68	8	tools	tool	NNS
cord-264884-ydkigome	68	9	have	have	VBP
cord-264884-ydkigome	68	10	provided	provide	VBN
cord-264884-ydkigome	68	11	crucial	crucial	JJ
cord-264884-ydkigome	68	12	insights	insight	NNS
cord-264884-ydkigome	68	13	into	into	IN
cord-264884-ydkigome	68	14	virus	virus	NN
cord-264884-ydkigome	68	15	origin	origin	NN
cord-264884-ydkigome	68	16	and	and	CC
cord-264884-ydkigome	68	17	evolution	evolution	NN
cord-264884-ydkigome	68	18	.	.	.
cord-264884-ydkigome	69	1	Yet	yet	CC
cord-264884-ydkigome	69	2	these	these	DT
cord-264884-ydkigome	69	3	methods	method	NNS
cord-264884-ydkigome	69	4	struggle	struggle	VBP
cord-264884-ydkigome	69	5	to	to	TO
cord-264884-ydkigome	69	6	incorporate	incorporate	VB
cord-264884-ydkigome	69	7	the	the	DT
cord-264884-ydkigome	69	8	fuzzy	fuzzy	JJ
cord-264884-ydkigome	69	9	nature	nature	NN
cord-264884-ydkigome	69	10	of	of	IN
cord-264884-ydkigome	69	11	viruses	virus	NNS
cord-264884-ydkigome	69	12	and	and	CC
cord-264884-ydkigome	69	13	have	have	VBP
cord-264884-ydkigome	69	14	clear	clear	JJ
cord-264884-ydkigome	69	15	limits	limit	NNS
cord-264884-ydkigome	69	16	,	,	,
cord-264884-ydkigome	69	17	especially	especially	RB
cord-264884-ydkigome	69	18	regarding	regard	VBG
cord-264884-ydkigome	69	19	quasispecies	quasispecie	NNS
cord-264884-ydkigome	69	20	and	and	CC
cord-264884-ydkigome	69	21	high	high	JJ
cord-264884-ydkigome	69	22	recombination	recombination	NN
cord-264884-ydkigome	69	23	rates	rate	NNS
cord-264884-ydkigome	69	24	.	.	.
cord-264884-ydkigome	70	1	Structural	structural	JJ
cord-264884-ydkigome	70	2	biology	biology	NN
cord-264884-ydkigome	70	3	now	now	RB
cord-264884-ydkigome	70	4	also	also	RB
cord-264884-ydkigome	70	5	adds	add	VBZ
cord-264884-ydkigome	70	6	tools	tool	NNS
cord-264884-ydkigome	70	7	that	that	WDT
cord-264884-ydkigome	70	8	extend	extend	VBP
cord-264884-ydkigome	70	9	our	-PRON-	PRP$
cord-264884-ydkigome	70	10	vision	vision	NN
cord-264884-ydkigome	70	11	of	of	IN
cord-264884-ydkigome	70	12	virus	virus	NN
cord-264884-ydkigome	70	13	evolution	evolution	NN
cord-264884-ydkigome	70	14	beyond	beyond	IN
cord-264884-ydkigome	70	15	what	what	WP
cord-264884-ydkigome	70	16	can	can	MD
cord-264884-ydkigome	70	17	be	be	VB
cord-264884-ydkigome	70	18	seen	see	VBN
cord-264884-ydkigome	70	19	in	in	IN
cord-264884-ydkigome	70	20	the	the	DT
cord-264884-ydkigome	70	21	genetic	genetic	JJ
cord-264884-ydkigome	70	22	sequence	sequence	NN
cord-264884-ydkigome	70	23	.	.	.
cord-264884-ydkigome	71	1	For	for	IN
cord-264884-ydkigome	71	2	example	example	NN
cord-264884-ydkigome	71	3	,	,	,
cord-264884-ydkigome	71	4	common	common	JJ
cord-264884-ydkigome	71	5	structural	structural	JJ
cord-264884-ydkigome	71	6	motifs	motif	NNS
cord-264884-ydkigome	71	7	from	from	IN
cord-264884-ydkigome	71	8	phage	phage	NN
cord-264884-ydkigome	71	9	to	to	IN
cord-264884-ydkigome	71	10	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	71	11	DNA	dna	NN
cord-264884-ydkigome	71	12	viruses	virus	NNS
cord-264884-ydkigome	71	13	(	(	-LRB-
cord-264884-ydkigome	71	14	T4	T4	NNP
cord-264884-ydkigome	71	15	and	and	CC
cord-264884-ydkigome	71	16	herpesvirus	herpesvirus	NNP
cord-264884-ydkigome	71	17	)	)	-RRB-
cord-264884-ydkigome	71	18	suggest	suggest	VBP
cord-264884-ydkigome	71	19	very	very	RB
cord-264884-ydkigome	71	20	ancient	ancient	JJ
cord-264884-ydkigome	71	21	links	link	NNS
cord-264884-ydkigome	71	22	in	in	IN
cord-264884-ydkigome	71	23	virus	virus	NN
cord-264884-ydkigome	71	24	evolution	evolution	NN
cord-264884-ydkigome	71	25	that	that	WDT
cord-264884-ydkigome	71	26	span	span	VBP
cord-264884-ydkigome	71	27	all	all	DT
cord-264884-ydkigome	71	28	domains	domain	NNS
cord-264884-ydkigome	71	29	of	of	IN
cord-264884-ydkigome	71	30	life	life	NN
cord-264884-ydkigome	71	31	(	(	-LRB-
cord-264884-ydkigome	71	32	see	see	VB
cord-264884-ydkigome	71	33	below	below	RB
cord-264884-ydkigome	71	34	)	)	-RRB-
cord-264884-ydkigome	71	35	.	.	.
cord-264884-ydkigome	72	1	Nevertheless	nevertheless	RB
cord-264884-ydkigome	72	2	,	,	,
cord-264884-ydkigome	72	3	our	-PRON-	PRP$
cord-264884-ydkigome	72	4	analytical	analytical	JJ
cord-264884-ydkigome	72	5	methods	method	NNS
cord-264884-ydkigome	72	6	are	be	VBP
cord-264884-ydkigome	72	7	currently	currently	RB
cord-264884-ydkigome	72	8	lacking	lack	VBG
cord-264884-ydkigome	72	9	as	as	IN
cord-264884-ydkigome	72	10	we	-PRON-	PRP
cord-264884-ydkigome	72	11	struggle	struggle	VBP
cord-264884-ydkigome	72	12	to	to	TO
cord-264884-ydkigome	72	13	understand	understand	VB
cord-264884-ydkigome	72	14	complex	complex	JJ
cord-264884-ydkigome	72	15	genetic	genetic	JJ
cord-264884-ydkigome	72	16	mixtures	mixture	NNS
cord-264884-ydkigome	72	17	that	that	WDT
cord-264884-ydkigome	72	18	provide	provide	VBP
cord-264884-ydkigome	72	19	fi	fi	NN
cord-264884-ydkigome	72	20	tness	tness	NN
cord-264884-ydkigome	72	21	,	,	,
cord-264884-ydkigome	72	22	reticulated	reticulated	JJ
cord-264884-ydkigome	72	23	relationships	relationship	NNS
cord-264884-ydkigome	72	24	,	,	,
cord-264884-ydkigome	72	25	polyphyletic	polyphyletic	JJ
cord-264884-ydkigome	72	26	origins	origin	NNS
cord-264884-ydkigome	72	27	,	,	,
cord-264884-ydkigome	72	28	and	and	CC
cord-264884-ydkigome	72	29	virus	virus	NN
cord-264884-ydkigome	72	30	-	-	HYPH
cord-264884-ydkigome	72	31	host	host	NN
cord-264884-ydkigome	72	32	congruence	congruence	NN
cord-264884-ydkigome	72	33	.	.	.
cord-264884-ydkigome	73	1	Virus	virus	NN
cord-264884-ydkigome	73	2	evolution	evolution	NN
cord-264884-ydkigome	73	3	has	have	VBZ
cord-264884-ydkigome	73	4	,	,	,
cord-264884-ydkigome	73	5	for	for	IN
cord-264884-ydkigome	73	6	the	the	DT
cord-264884-ydkigome	73	7	most	most	JJS
cord-264884-ydkigome	73	8	part	part	NN
cord-264884-ydkigome	73	9	,	,	,
cord-264884-ydkigome	73	10	been	be	VBN
cord-264884-ydkigome	73	11	considered	consider	VBN
cord-264884-ydkigome	73	12	to	to	TO
cord-264884-ydkigome	73	13	be	be	VB
cord-264884-ydkigome	73	14	a	a	DT
cord-264884-ydkigome	73	15	specifi	specifi	NN
cord-264884-ydkigome	73	16	c	c	NN
cord-264884-ydkigome	73	17	,	,	,
cord-264884-ydkigome	73	18	esoteric	esoteric	JJ
cord-264884-ydkigome	73	19	part	part	NN
cord-264884-ydkigome	73	20	of	of	IN
cord-264884-ydkigome	73	21	broader	broad	JJR
cord-264884-ydkigome	73	22	evolutionary	evolutionary	JJ
cord-264884-ydkigome	73	23	biology	biology	NN
cord-264884-ydkigome	73	24	and	and	CC
cord-264884-ydkigome	73	25	has	have	VBZ
cord-264884-ydkigome	73	26	been	be	VBN
cord-264884-ydkigome	73	27	given	give	VBN
cord-264884-ydkigome	73	28	limited	limited	JJ
cord-264884-ydkigome	73	29	attention	attention	NN
cord-264884-ydkigome	73	30	in	in	IN
cord-264884-ydkigome	73	31	reference	reference	NN
cord-264884-ydkigome	73	32	works	work	VBZ
cord-264884-ydkigome	73	33	on	on	IN
cord-264884-ydkigome	73	34	evolutionary	evolutionary	JJ
cord-264884-ydkigome	73	35	biology	biology	NN
cord-264884-ydkigome	73	36	(	(	-LRB-
cord-264884-ydkigome	73	37	see	see	VB
cord-264884-ydkigome	73	38	Pagel	Pagel	NNP
cord-264884-ydkigome	73	39	,	,	,
cord-264884-ydkigome	73	40	2002	2002	CD
cord-264884-ydkigome	73	41	)	)	-RRB-
cord-264884-ydkigome	73	42	.	.	.
cord-264884-ydkigome	74	1	Historically	historically	RB
cord-264884-ydkigome	74	2	,	,	,
cord-264884-ydkigome	74	3	the	the	DT
cord-264884-ydkigome	74	4	focus	focus	NN
cord-264884-ydkigome	74	5	has	have	VBZ
cord-264884-ydkigome	74	6	been	be	VBN
cord-264884-ydkigome	74	7	on	on	IN
cord-264884-ydkigome	74	8	various	various	JJ
cord-264884-ydkigome	74	9	RNA	RNA	NNP
cord-264884-ydkigome	74	10	viruses	virus	NNS
cord-264884-ydkigome	74	11	and	and	CC
cord-264884-ydkigome	74	12	some	some	DT
cord-264884-ydkigome	74	13	DNA	dna	NN
cord-264884-ydkigome	74	14	viruses	virus	NNS
cord-264884-ydkigome	74	15	that	that	WDT
cord-264884-ydkigome	74	16	cause	cause	VBP
cord-264884-ydkigome	74	17	disease	disease	NN
cord-264884-ydkigome	74	18	in	in	IN
cord-264884-ydkigome	74	19	humans	human	NNS
cord-264884-ydkigome	74	20	and	and	CC
cord-264884-ydkigome	74	21	domesticated	domesticated	JJ
cord-264884-ydkigome	74	22	animals	animal	NNS
cord-264884-ydkigome	74	23	and	and	CC
cord-264884-ydkigome	74	24	plants	plant	NNS
cord-264884-ydkigome	74	25	.	.	.
cord-264884-ydkigome	75	1	However	however	RB
cord-264884-ydkigome	75	2	,	,	,
cord-264884-ydkigome	75	3	I	-PRON-	PRP
cord-264884-ydkigome	75	4	have	have	VBP
cord-264884-ydkigome	75	5	asserted	assert	VBN
cord-264884-ydkigome	75	6	that	that	IN
cord-264884-ydkigome	75	7	all	all	DT
cord-264884-ydkigome	75	8	life	life	NN
cord-264884-ydkigome	75	9	forms	form	NNS
cord-264884-ydkigome	75	10	must	must	MD
cord-264884-ydkigome	75	11	be	be	VB
cord-264884-ydkigome	75	12	examined	examine	VBN
cord-264884-ydkigome	75	13	from	from	IN
cord-264884-ydkigome	75	14	the	the	DT
cord-264884-ydkigome	75	15	perspective	perspective	NN
cord-264884-ydkigome	75	16	of	of	IN
cord-264884-ydkigome	75	17	virus	virus	NN
cord-264884-ydkigome	75	18	evolution	evolution	NN
cord-264884-ydkigome	75	19	(	(	-LRB-
cord-264884-ydkigome	75	20	Villarreal	Villarreal	NNP
cord-264884-ydkigome	75	21	,	,	,
cord-264884-ydkigome	75	22	2005	2005	CD
cord-264884-ydkigome	75	23	)	)	-RRB-
cord-264884-ydkigome	75	24	,	,	,
cord-264884-ydkigome	75	25	not	not	RB
cord-264884-ydkigome	75	26	just	just	RB
cord-264884-ydkigome	75	27	those	those	DT
cord-264884-ydkigome	75	28	pathogens	pathogen	NNS
cord-264884-ydkigome	75	29	that	that	WDT
cord-264884-ydkigome	75	30	impact	impact	VBP
cord-264884-ydkigome	75	31	on	on	IN
cord-264884-ydkigome	75	32	us	-PRON-	PRP
cord-264884-ydkigome	75	33	.	.	.
cord-264884-ydkigome	76	1	How	how	WRB
cord-264884-ydkigome	76	2	viruses	virus	NNS
cord-264884-ydkigome	76	3	evolve	evolve	VBP
cord-264884-ydkigome	76	4	in	in	IN
cord-264884-ydkigome	76	5	a	a	DT
cord-264884-ydkigome	76	6	more	more	RBR
cord-264884-ydkigome	76	7	general	general	JJ
cord-264884-ydkigome	76	8	sense	sense	NN
cord-264884-ydkigome	76	9	informs	inform	VBZ
cord-264884-ydkigome	76	10	us	-PRON-	PRP
cord-264884-ydkigome	76	11	of	of	IN
cord-264884-ydkigome	76	12	evolutionary	evolutionary	JJ
cord-264884-ydkigome	76	13	paradigms	paradigm	NNS
cord-264884-ydkigome	76	14	that	that	WDT
cord-264884-ydkigome	76	15	have	have	VBP
cord-264884-ydkigome	76	16	not	not	RB
cord-264884-ydkigome	76	17	been	be	VBN
cord-264884-ydkigome	76	18	previously	previously	RB
cord-264884-ydkigome	76	19	well	well	RB
cord-264884-ydkigome	76	20	understood	understand	VBN
cord-264884-ydkigome	76	21	(	(	-LRB-
cord-264884-ydkigome	76	22	especially	especially	RB
cord-264884-ydkigome	76	23	the	the	DT
cord-264884-ydkigome	76	24	evolution	evolution	NN
cord-264884-ydkigome	76	25	of	of	IN
cord-264884-ydkigome	76	26	consortia	consortium	NNS
cord-264884-ydkigome	76	27	or	or	CC
cord-264884-ydkigome	76	28	the	the	DT
cord-264884-ydkigome	76	29	dynamics	dynamic	NNS
cord-264884-ydkigome	76	30	of	of	IN
cord-264884-ydkigome	76	31	vast	vast	JJ
cord-264884-ydkigome	76	32	reticulated	reticulated	JJ
cord-264884-ydkigome	76	33	gene	gene	NN
cord-264884-ydkigome	76	34	pools	pool	NNS
cord-264884-ydkigome	76	35	)	)	-RRB-
cord-264884-ydkigome	76	36	.	.	.
cord-264884-ydkigome	77	1	This	this	DT
cord-264884-ydkigome	77	2	volume	volume	NN
cord-264884-ydkigome	77	3	now	now	RB
cord-264884-ydkigome	77	4	extends	extend	VBZ
cord-264884-ydkigome	77	5	these	these	DT
cord-264884-ydkigome	77	6	traditional	traditional	JJ
cord-264884-ydkigome	77	7	topics	topic	NNS
cord-264884-ydkigome	77	8	of	of	IN
cord-264884-ydkigome	77	9	virus	virus	NN
cord-264884-ydkigome	77	10	evolution	evolution	NN
cord-264884-ydkigome	77	11	to	to	TO
cord-264884-ydkigome	77	12	include	include	VB
cord-264884-ydkigome	77	13	the	the	DT
cord-264884-ydkigome	77	14	vast	vast	JJ
cord-264884-ydkigome	77	15	virology	virology	NN
cord-264884-ydkigome	77	16	of	of	IN
cord-264884-ydkigome	77	17	the	the	DT
cord-264884-ydkigome	77	18	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	77	19	world	world	NN
cord-264884-ydkigome	77	20	.	.	.
cord-264884-ydkigome	78	1	In	in	IN
cord-264884-ydkigome	78	2	so	so	RB
cord-264884-ydkigome	78	3	doing	do	VBG
cord-264884-ydkigome	78	4	,	,	,
cord-264884-ydkigome	78	5	it	-PRON-	PRP
cord-264884-ydkigome	78	6	illuminates	illuminate	VBZ
cord-264884-ydkigome	78	7	the	the	DT
cord-264884-ydkigome	78	8	global	global	JJ
cord-264884-ydkigome	78	9	consequences	consequence	NNS
cord-264884-ydkigome	78	10	viruses	virus	NNS
cord-264884-ydkigome	78	11	have	have	VBP
cord-264884-ydkigome	78	12	had	have	VBN
cord-264884-ydkigome	78	13	on	on	IN
cord-264884-ydkigome	78	14	all	all	DT
cord-264884-ydkigome	78	15	life	life	NN
cord-264884-ydkigome	78	16	forms	form	NNS
cord-264884-ydkigome	78	17	.	.	.
cord-264884-ydkigome	79	1	Prior	prior	RB
cord-264884-ydkigome	79	2	to	to	IN
cord-264884-ydkigome	79	3	the	the	DT
cord-264884-ydkigome	79	4	1970s	1970	NNS
cord-264884-ydkigome	79	5	we	-PRON-	PRP
cord-264884-ydkigome	79	6	saw	see	VBD
cord-264884-ydkigome	79	7	some	some	DT
cord-264884-ydkigome	79	8	stunning	stunning	JJ
cord-264884-ydkigome	79	9	successes	success	NNS
cord-264884-ydkigome	79	10	in	in	IN
cord-264884-ydkigome	79	11	vaccine	vaccine	NN
cord-264884-ydkigome	79	12	control	control	NN
cord-264884-ydkigome	79	13	for	for	IN
cord-264884-ydkigome	79	14	major	major	JJ
cord-264884-ydkigome	79	15	viral	viral	JJ
cord-264884-ydkigome	79	16	human	human	JJ
cord-264884-ydkigome	79	17	diseases	disease	NNS
cord-264884-ydkigome	79	18	,	,	,
cord-264884-ydkigome	79	19	such	such	JJ
cord-264884-ydkigome	79	20	as	as	IN
cord-264884-ydkigome	79	21	polio	polio	NN
cord-264884-ydkigome	79	22	,	,	,
cord-264884-ydkigome	79	23	measles	measle	NNS
cord-264884-ydkigome	79	24	,	,	,
cord-264884-ydkigome	79	25	mumps	mumps	NN
cord-264884-ydkigome	79	26	,	,	,
cord-264884-ydkigome	79	27	infl	infl	NNP
cord-264884-ydkigome	79	28	uenza	uenza	NNP
cord-264884-ydkigome	79	29	,	,	,
cord-264884-ydkigome	79	30	and	and	CC
cord-264884-ydkigome	79	31	especially	especially	RB
cord-264884-ydkigome	79	32	smallpox	smallpox	NN
cord-264884-ydkigome	79	33	virus	virus	NN
cord-264884-ydkigome	79	34	.	.	.
cord-264884-ydkigome	80	1	Due	due	IN
cord-264884-ydkigome	80	2	to	to	IN
cord-264884-ydkigome	80	3	this	this	DT
cord-264884-ydkigome	80	4	historic	historic	JJ
cord-264884-ydkigome	80	5	success	success	NN
cord-264884-ydkigome	80	6	,	,	,
cord-264884-ydkigome	80	7	American	american	JJ
cord-264884-ydkigome	80	8	health	health	NN
cord-264884-ydkigome	80	9	agencies	agency	NNS
cord-264884-ydkigome	80	10	and	and	CC
cord-264884-ydkigome	80	11	educators	educator	NNS
cord-264884-ydkigome	80	12	considered	consider	VBD
cord-264884-ydkigome	80	13	virus	virus	NN
cord-264884-ydkigome	80	14	disease	disease	NN
cord-264884-ydkigome	80	15	as	as	IN
cord-264884-ydkigome	80	16	a	a	DT
cord-264884-ydkigome	80	17	thing	thing	NN
cord-264884-ydkigome	80	18	of	of	IN
cord-264884-ydkigome	80	19	the	the	DT
cord-264884-ydkigome	80	20	past	past	NN
cord-264884-ydkigome	80	21	,	,	,
cord-264884-ydkigome	80	22	no	no	RB
cord-264884-ydkigome	80	23	longer	long	RBR
cord-264884-ydkigome	80	24	a	a	DT
cord-264884-ydkigome	80	25	serious	serious	JJ
cord-264884-ydkigome	80	26	threat	threat	NN
cord-264884-ydkigome	80	27	.	.	.
cord-264884-ydkigome	81	1	The	the	DT
cord-264884-ydkigome	81	2	era	era	NN
cord-264884-ydkigome	81	3	of	of	IN
cord-264884-ydkigome	81	4	infectious	infectious	JJ
cord-264884-ydkigome	81	5	disease	disease	NN
cord-264884-ydkigome	81	6	that	that	WDT
cord-264884-ydkigome	81	7	they	-PRON-	PRP
cord-264884-ydkigome	81	8	represented	represent	VBD
cord-264884-ydkigome	81	9	was	be	VBD
cord-264884-ydkigome	81	10	now	now	RB
cord-264884-ydkigome	81	11	one	one	CD
cord-264884-ydkigome	81	12	for	for	IN
cord-264884-ydkigome	81	13	the	the	DT
cord-264884-ydkigome	81	14	historical	historical	JJ
cord-264884-ydkigome	81	15	record	record	NN
cord-264884-ydkigome	81	16	,	,	,
cord-264884-ydkigome	81	17	an	an	DT
cord-264884-ydkigome	81	18	unfortunate	unfortunate	JJ
cord-264884-ydkigome	81	19	part	part	NN
cord-264884-ydkigome	81	20	of	of	IN
cord-264884-ydkigome	81	21	human	human	JJ
cord-264884-ydkigome	81	22	history	history	NN
cord-264884-ydkigome	81	23	,	,	,
cord-264884-ydkigome	81	24	or	or	CC
cord-264884-ydkigome	81	25	so	so	RB
cord-264884-ydkigome	81	26	we	-PRON-	PRP
cord-264884-ydkigome	81	27	thought	think	VBD
cord-264884-ydkigome	81	28	.	.	.
cord-264884-ydkigome	82	1	In	in	IN
cord-264884-ydkigome	82	2	what	what	WP
cord-264884-ydkigome	82	3	now	now	RB
cord-264884-ydkigome	82	4	seems	seem	VBZ
cord-264884-ydkigome	82	5	to	to	TO
cord-264884-ydkigome	82	6	have	have	VB
cord-264884-ydkigome	82	7	been	be	VBN
cord-264884-ydkigome	82	8	a	a	DT
cord-264884-ydkigome	82	9	clear	clear	JJ
cord-264884-ydkigome	82	10	case	case	NN
cord-264884-ydkigome	82	11	of	of	IN
cord-264884-ydkigome	82	12	hubris	hubris	NN
cord-264884-ydkigome	82	13	and	and	CC
cord-264884-ydkigome	82	14	naivety	naivety	NN
cord-264884-ydkigome	82	15	,	,	,
cord-264884-ydkigome	82	16	we	-PRON-	PRP
cord-264884-ydkigome	82	17	have	have	VBP
cord-264884-ydkigome	82	18	been	be	VBN
cord-264884-ydkigome	82	19	humbled	humble	VBN
cord-264884-ydkigome	82	20	by	by	IN
cord-264884-ydkigome	82	21	the	the	DT
cord-264884-ydkigome	82	22	evolutionary	evolutionary	JJ
cord-264884-ydkigome	82	23	power	power	NN
cord-264884-ydkigome	82	24	of	of	IN
cord-264884-ydkigome	82	25	viruses	virus	NNS
cord-264884-ydkigome	82	26	,	,	,
cord-264884-ydkigome	82	27	which	which	WDT
cord-264884-ydkigome	82	28	was	be	VBD
cord-264884-ydkigome	82	29	woefully	woefully	RB
cord-264884-ydkigome	82	30	underappreciated	underappreciated	JJ
cord-264884-ydkigome	82	31	,	,	,
cord-264884-ydkigome	82	32	even	even	RB
cord-264884-ydkigome	82	33	by	by	IN
cord-264884-ydkigome	82	34	most	most	JJS
cord-264884-ydkigome	82	35	virologists	virologist	NNS
cord-264884-ydkigome	82	36	.	.	.
cord-264884-ydkigome	83	1	By	by	IN
cord-264884-ydkigome	83	2	the	the	DT
cord-264884-ydkigome	83	3	end	end	NN
cord-264884-ydkigome	83	4	of	of	IN
cord-264884-ydkigome	83	5	that	that	DT
cord-264884-ydkigome	83	6	decade	decade	NN
cord-264884-ydkigome	83	7	,	,	,
cord-264884-ydkigome	83	8	the	the	DT
cord-264884-ydkigome	83	9	evolution	evolution	NN
cord-264884-ydkigome	83	10	and	and	CC
cord-264884-ydkigome	83	11	emergence	emergence	NN
cord-264884-ydkigome	83	12	of	of	IN
cord-264884-ydkigome	83	13	HIV-1	HIV-1	NNP
cord-264884-ydkigome	83	14	permanently	permanently	RB
cord-264884-ydkigome	83	15	changed	change	VBD
cord-264884-ydkigome	83	16	our	-PRON-	PRP$
cord-264884-ydkigome	83	17	views	view	NNS
cord-264884-ydkigome	83	18	(	(	-LRB-
cord-264884-ydkigome	83	19	see	see	VB
cord-264884-ydkigome	83	20	Chapters	Chapters	NNPS
cord-264884-ydkigome	83	21	13	13	CD
cord-264884-ydkigome	83	22	and	and	CC
cord-264884-ydkigome	83	23	14	14	CD
cord-264884-ydkigome	83	24	)	)	-RRB-
cord-264884-ydkigome	83	25	.	.	.
cord-264884-ydkigome	84	1	This	this	DT
cord-264884-ydkigome	84	2	has	have	VBZ
cord-264884-ydkigome	84	3	also	also	RB
cord-264884-ydkigome	84	4	been	be	VBN
cord-264884-ydkigome	84	5	followed	follow	VBN
cord-264884-ydkigome	84	6	by	by	IN
cord-264884-ydkigome	84	7	a	a	DT
cord-264884-ydkigome	84	8	seemingly	seemingly	RB
cord-264884-ydkigome	84	9	never	never	RB
cord-264884-ydkigome	84	10	-	-	HYPH
cord-264884-ydkigome	84	11	ending	end	VBG
cord-264884-ydkigome	84	12	series	series	NN
cord-264884-ydkigome	84	13	of	of	IN
cord-264884-ydkigome	84	14	viral	viral	JJ
cord-264884-ydkigome	84	15	threats	threat	NNS
cord-264884-ydkigome	84	16	as	as	IN
cord-264884-ydkigome	84	17	newly	newly	RB
cord-264884-ydkigome	84	18	emerging	emerge	VBG
cord-264884-ydkigome	84	19	viral	viral	JJ
cord-264884-ydkigome	84	20	diseases	disease	NNS
cord-264884-ydkigome	84	21	have	have	VBP
cord-264884-ydkigome	84	22	come	come	VBN
cord-264884-ydkigome	84	23	to	to	IN
cord-264884-ydkigome	84	24	our	-PRON-	PRP$
cord-264884-ydkigome	84	25	attention	attention	NN
cord-264884-ydkigome	84	26	.	.	.
cord-264884-ydkigome	85	1	HIV-1	HIV-1	NNP
cord-264884-ydkigome	85	2	provides	provide	VBZ
cord-264884-ydkigome	85	3	the	the	DT
cord-264884-ydkigome	85	4	only	only	JJ
cord-264884-ydkigome	85	5	example	example	NN
cord-264884-ydkigome	85	6	of	of	IN
cord-264884-ydkigome	85	7	a	a	DT
cord-264884-ydkigome	85	8	public	public	JJ
cord-264884-ydkigome	85	9	health	health	NN
cord-264884-ydkigome	85	10	situation	situation	NN
cord-264884-ydkigome	85	11	that	that	WDT
cord-264884-ydkigome	85	12	has	have	VBZ
cord-264884-ydkigome	85	13	reversed	reverse	VBN
cord-264884-ydkigome	85	14	centuries	century	NNS
cord-264884-ydkigome	85	15	of	of	IN
cord-264884-ydkigome	85	16	progress	progress	NN
cord-264884-ydkigome	85	17	for	for	IN
cord-264884-ydkigome	85	18	extending	extend	VBG
cord-264884-ydkigome	85	19	human	human	JJ
cord-264884-ydkigome	85	20	health	health	NN
cord-264884-ydkigome	85	21	and	and	CC
cord-264884-ydkigome	85	22	lifespan	lifespan	NN
cord-264884-ydkigome	85	23	.	.	.
cord-264884-ydkigome	86	1	It	-PRON-	PRP
cord-264884-ydkigome	86	2	now	now	RB
cord-264884-ydkigome	86	3	limits	limit	VBZ
cord-264884-ydkigome	86	4	human	human	JJ
cord-264884-ydkigome	86	5	life	life	NN
cord-264884-ydkigome	86	6	expectancy	expectancy	NN
cord-264884-ydkigome	86	7	in	in	IN
cord-264884-ydkigome	86	8	many	many	JJ
cord-264884-ydkigome	86	9	parts	part	NNS
cord-264884-ydkigome	86	10	of	of	IN
cord-264884-ydkigome	86	11	the	the	DT
cord-264884-ydkigome	86	12	world	world	NN
cord-264884-ydkigome	86	13	,	,	,
cord-264884-ydkigome	86	14	especially	especially	RB
cord-264884-ydkigome	86	15	sub	sub	JJ
cord-264884-ydkigome	86	16	-	-	JJ
cord-264884-ydkigome	86	17	Saharian	saharian	JJ
cord-264884-ydkigome	86	18	Africa	Africa	NNP
cord-264884-ydkigome	86	19	.	.	.
cord-264884-ydkigome	87	1	This	this	DT
cord-264884-ydkigome	87	2	development	development	NN
cord-264884-ydkigome	87	3	could	could	MD
cord-264884-ydkigome	87	4	not	not	RB
cord-264884-ydkigome	87	5	have	have	VB
cord-264884-ydkigome	87	6	been	be	VBN
cord-264884-ydkigome	87	7	imagined	imagine	VBN
cord-264884-ydkigome	87	8	in	in	IN
cord-264884-ydkigome	87	9	the	the	DT
cord-264884-ydkigome	87	10	1970s	1970	NNS
cord-264884-ydkigome	87	11	.	.	.
cord-264884-ydkigome	88	1	We	-PRON-	PRP
cord-264884-ydkigome	88	2	are	be	VBP
cord-264884-ydkigome	88	3	much	much	RB
cord-264884-ydkigome	88	4	less	less	JJR
cord-264884-ydkigome	88	5	confi	confi	NN
cord-264884-ydkigome	88	6	dent	dent	NN
cord-264884-ydkigome	88	7	now	now	RB
cord-264884-ydkigome	88	8	about	about	IN
cord-264884-ydkigome	88	9	predicting	predict	VBG
cord-264884-ydkigome	88	10	the	the	DT
cord-264884-ydkigome	88	11	future	future	NN
cord-264884-ydkigome	88	12	of	of	IN
cord-264884-ydkigome	88	13	virus	virus	NN
cord-264884-ydkigome	88	14	evolution	evolution	NN
cord-264884-ydkigome	88	15	and	and	CC
cord-264884-ydkigome	88	16	its	-PRON-	PRP$
cord-264884-ydkigome	88	17	potential	potential	JJ
cord-264884-ydkigome	88	18	impact	impact	NN
cord-264884-ydkigome	88	19	on	on	IN
cord-264884-ydkigome	88	20	human	human	JJ
cord-264884-ydkigome	88	21	health	health	NN
cord-264884-ydkigome	88	22	.	.	.
cord-264884-ydkigome	89	1	Diseases	disease	NNS
cord-264884-ydkigome	89	2	of	of	IN
cord-264884-ydkigome	89	3	domesticated	domesticated	JJ
cord-264884-ydkigome	89	4	microbiological	microbiological	JJ
cord-264884-ydkigome	89	5	,	,	,
cord-264884-ydkigome	89	6	plant	plant	NN
cord-264884-ydkigome	89	7	,	,	,
cord-264884-ydkigome	89	8	and	and	CC
cord-264884-ydkigome	89	9	animal	animal	NN
cord-264884-ydkigome	89	10	species	specie	NNS
cord-264884-ydkigome	89	11	have	have	VBP
cord-264884-ydkigome	89	12	also	also	RB
cord-264884-ydkigome	89	13	experienced	experience	VBN
cord-264884-ydkigome	89	14	the	the	DT
cord-264884-ydkigome	89	15	trauma	trauma	NN
cord-264884-ydkigome	89	16	of	of	IN
cord-264884-ydkigome	89	17	the	the	DT
cord-264884-ydkigome	89	18	consequences	consequence	NNS
cord-264884-ydkigome	89	19	of	of	IN
cord-264884-ydkigome	89	20	emerging	emerge	VBG
cord-264884-ydkigome	89	21	viral	viral	JJ
cord-264884-ydkigome	89	22	diseases	disease	NNS
cord-264884-ydkigome	89	23	along	along	IN
cord-264884-ydkigome	89	24	with	with	IN
cord-264884-ydkigome	89	25	huge	huge	JJ
cord-264884-ydkigome	89	26	losses	loss	NNS
cord-264884-ydkigome	89	27	.	.	.
cord-264884-ydkigome	90	1	However	however	RB
cord-264884-ydkigome	90	2	,	,	,
cord-264884-ydkigome	90	3	the	the	DT
cord-264884-ydkigome	90	4	human	human	JJ
cord-264884-ydkigome	90	5	HIV-1	HIV-1	NNP
cord-264884-ydkigome	90	6	story	story	NN
cord-264884-ydkigome	90	7	may	may	MD
cord-264884-ydkigome	90	8	not	not	RB
cord-264884-ydkigome	90	9	be	be	VB
cord-264884-ydkigome	90	10	a	a	DT
cord-264884-ydkigome	90	11	fl	fl	JJ
cord-264884-ydkigome	90	12	uke	uke	NN
cord-264884-ydkigome	90	13	of	of	IN
cord-264884-ydkigome	90	14	virology	virology	NN
cord-264884-ydkigome	90	15	but	but	CC
cord-264884-ydkigome	90	16	may	may	MD
cord-264884-ydkigome	90	17	be	be	VB
cord-264884-ydkigome	90	18	telling	tell	VBG
cord-264884-ydkigome	90	19	us	-PRON-	PRP
cord-264884-ydkigome	90	20	something	something	NN
cord-264884-ydkigome	90	21	basic	basic	JJ
cord-264884-ydkigome	90	22	about	about	IN
cord-264884-ydkigome	90	23	human	human	JJ
cord-264884-ydkigome	90	24	and	and	CC
cord-264884-ydkigome	90	25	primate	primate	JJ
cord-264884-ydkigome	90	26	evolution	evolution	NN
cord-264884-ydkigome	90	27	.	.	.
cord-264884-ydkigome	91	1	As	as	IN
cord-264884-ydkigome	91	2	we	-PRON-	PRP
cord-264884-ydkigome	91	3	sought	seek	VBD
cord-264884-ydkigome	91	4	to	to	TO
cord-264884-ydkigome	91	5	understand	understand	VB
cord-264884-ydkigome	91	6	the	the	DT
cord-264884-ydkigome	91	7	origin	origin	NN
cord-264884-ydkigome	91	8	of	of	IN
cord-264884-ydkigome	91	9	this	this	DT
cord-264884-ydkigome	91	10	new	new	JJ
cord-264884-ydkigome	91	11	virus	virus	NN
cord-264884-ydkigome	91	12	,	,	,
cord-264884-ydkigome	91	13	we	-PRON-	PRP
cord-264884-ydkigome	91	14	have	have	VBP
cord-264884-ydkigome	91	15	come	come	VBN
cord-264884-ydkigome	91	16	to	to	TO
cord-264884-ydkigome	91	17	appreciate	appreciate	VB
cord-264884-ydkigome	91	18	a	a	DT
cord-264884-ydkigome	91	19	much	much	RB
cord-264884-ydkigome	91	20	broader	broad	JJR
cord-264884-ydkigome	91	21	virus	virus	NN
cord-264884-ydkigome	91	22	-	-	HYPH
cord-264884-ydkigome	91	23	host	host	NN
cord-264884-ydkigome	91	24	story	story	NN
cord-264884-ydkigome	91	25	which	which	WDT
cord-264884-ydkigome	91	26	involves	involve	VBZ
cord-264884-ydkigome	91	27	simian	simian	JJ
cord-264884-ydkigome	91	28	immunodefi	immunodefi	NNP
cord-264884-ydkigome	91	29	ciency	ciency	NNP
cord-264884-ydkigome	91	30	virus	virus	NN
cord-264884-ydkigome	91	31	(	(	-LRB-
cord-264884-ydkigome	91	32	SIV	SIV	NNP
cord-264884-ydkigome	91	33	)	)	-RRB-
cord-264884-ydkigome	91	34	,	,	,
cord-264884-ydkigome	91	35	foamy	foamy	NN
cord-264884-ydkigome	91	36	viruses	virus	NNS
cord-264884-ydkigome	91	37	,	,	,
cord-264884-ydkigome	91	38	and	and	CC
cord-264884-ydkigome	91	39	the	the	DT
cord-264884-ydkigome	91	40	speciation	speciation	NN
cord-264884-ydkigome	91	41	of	of	IN
cord-264884-ydkigome	91	42	Old	Old	NNP
cord-264884-ydkigome	91	43	World	World	NNP
cord-264884-ydkigome	91	44	primates	primate	NNS
cord-264884-ydkigome	91	45	.	.	.
cord-264884-ydkigome	92	1	We	-PRON-	PRP
cord-264884-ydkigome	92	2	have	have	VBP
cord-264884-ydkigome	92	3	also	also	RB
cord-264884-ydkigome	92	4	come	come	VBN
cord-264884-ydkigome	92	5	to	to	TO
cord-264884-ydkigome	92	6	learn	learn	VB
cord-264884-ydkigome	92	7	that	that	IN
cord-264884-ydkigome	92	8	the	the	DT
cord-264884-ydkigome	92	9	genomes	genome	NNS
cord-264884-ydkigome	92	10	of	of	IN
cord-264884-ydkigome	92	11	these	these	DT
cord-264884-ydkigome	92	12	primates	primate	NNS
cord-264884-ydkigome	92	13	show	show	VBP
cord-264884-ydkigome	92	14	much	much	JJ
cord-264884-ydkigome	92	15	evidence	evidence	NN
cord-264884-ydkigome	92	16	of	of	IN
cord-264884-ydkigome	92	17	past	past	JJ
cord-264884-ydkigome	92	18	viral	viral	JJ
cord-264884-ydkigome	92	19	interaction	interaction	NN
cord-264884-ydkigome	92	20	and	and	CC
cord-264884-ydkigome	92	21	ongoing	ongoing	JJ
cord-264884-ydkigome	92	22	endogenous	endogenous	JJ
cord-264884-ydkigome	92	23	retrovirus	retrovirus	NN
cord-264884-ydkigome	92	24	colonization	colonization	NN
cord-264884-ydkigome	92	25	.	.	.
cord-264884-ydkigome	93	1	The	the	DT
cord-264884-ydkigome	93	2	evolution	evolution	NN
cord-264884-ydkigome	93	3	of	of	IN
cord-264884-ydkigome	93	4	retroviral	retroviral	JJ
cord-264884-ydkigome	93	5	endogenization	endogenization	NN
cord-264884-ydkigome	93	6	has	have	VBZ
cord-264884-ydkigome	93	7	taken	take	VBN
cord-264884-ydkigome	93	8	on	on	RP
cord-264884-ydkigome	93	9	a	a	DT
cord-264884-ydkigome	93	10	much	much	RB
cord-264884-ydkigome	93	11	greater	great	JJR
cord-264884-ydkigome	93	12	signifi	signifi	NNP
cord-264884-ydkigome	93	13	cance	cance	NN
cord-264884-ydkigome	93	14	in	in	IN
cord-264884-ydkigome	93	15	basic	basic	JJ
cord-264884-ydkigome	93	16	evolutionary	evolutionary	JJ
cord-264884-ydkigome	93	17	biology	biology	NN
cord-264884-ydkigome	93	18	.	.	.
cord-264884-ydkigome	94	1	Thus	thus	RB
cord-264884-ydkigome	94	2	it	-PRON-	PRP
cord-264884-ydkigome	94	3	is	be	VBZ
cord-264884-ydkigome	94	4	with	with	IN
cord-264884-ydkigome	94	5	great	great	JJ
cord-264884-ydkigome	94	6	interest	interest	NN
cord-264884-ydkigome	94	7	that	that	WDT
cord-264884-ydkigome	94	8	we	-PRON-	PRP
cord-264884-ydkigome	94	9	now	now	RB
cord-264884-ydkigome	94	10	study	study	VBP
cord-264884-ydkigome	94	11	the	the	DT
cord-264884-ydkigome	94	12	ongoing	ongoing	JJ
cord-264884-ydkigome	94	13	endogenization	endogenization	NN
cord-264884-ydkigome	94	14	of	of	IN
cord-264884-ydkigome	94	15	retroviruses	retrovirus	NNS
cord-264884-ydkigome	94	16	in	in	IN
cord-264884-ydkigome	94	17	the	the	DT
cord-264884-ydkigome	94	18	koala	koala	NNP
cord-264884-ydkigome	94	19	bear	bear	NNP
cord-264884-ydkigome	94	20	genome	genome	NNP
cord-264884-ydkigome	94	21	(	(	-LRB-
cord-264884-ydkigome	94	22	see	see	VB
cord-264884-ydkigome	94	23	below	below	RB
cord-264884-ydkigome	94	24	)	)	-RRB-
cord-264884-ydkigome	94	25	.	.	.
cord-264884-ydkigome	95	1	Historically	historically	RB
cord-264884-ydkigome	95	2	,	,	,
cord-264884-ydkigome	95	3	we	-PRON-	PRP
cord-264884-ydkigome	95	4	are	be	VBP
cord-264884-ydkigome	95	5	compelled	compel	VBN
cord-264884-ydkigome	95	6	to	to	TO
cord-264884-ydkigome	95	7	study	study	VB
cord-264884-ydkigome	95	8	viruses	virus	NNS
cord-264884-ydkigome	95	9	because	because	IN
cord-264884-ydkigome	95	10	they	-PRON-	PRP
cord-264884-ydkigome	95	11	can	can	MD
cord-264884-ydkigome	95	12	cause	cause	VB
cord-264884-ydkigome	95	13	serious	serious	JJ
cord-264884-ydkigome	95	14	disease	disease	NN
cord-264884-ydkigome	95	15	.	.	.
cord-264884-ydkigome	96	1	New	new	JJ
cord-264884-ydkigome	96	2	viruses	virus	NNS
cord-264884-ydkigome	96	3	come	come	VBP
cord-264884-ydkigome	96	4	to	to	IN
cord-264884-ydkigome	96	5	our	-PRON-	PRP$
cord-264884-ydkigome	96	6	attention	attention	NN
cord-264884-ydkigome	96	7	also	also	RB
cord-264884-ydkigome	96	8	mainly	mainly	RB
cord-264884-ydkigome	96	9	because	because	IN
cord-264884-ydkigome	96	10	of	of	IN
cord-264884-ydkigome	96	11	disease	disease	NN
cord-264884-ydkigome	96	12	.	.	.
cord-264884-ydkigome	97	1	It	-PRON-	PRP
cord-264884-ydkigome	97	2	is	be	VBZ
cord-264884-ydkigome	97	3	therefore	therefore	RB
cord-264884-ydkigome	97	4	understandable	understandable	JJ
cord-264884-ydkigome	97	5	that	that	IN
cord-264884-ydkigome	97	6	most	most	JJS
cord-264884-ydkigome	97	7	evolutionary	evolutionary	JJ
cord-264884-ydkigome	97	8	biologists	biologist	NNS
cord-264884-ydkigome	97	9	mainly	mainly	RB
cord-264884-ydkigome	97	10	think	think	VBP
cord-264884-ydkigome	97	11	of	of	IN
cord-264884-ydkigome	97	12	viruses	virus	NNS
cord-264884-ydkigome	97	13	strictly	strictly	RB
cord-264884-ydkigome	97	14	as	as	IN
cord-264884-ydkigome	97	15	agents	agent	NNS
cord-264884-ydkigome	97	16	of	of	IN
cord-264884-ydkigome	97	17	disease	disease	NN
cord-264884-ydkigome	97	18	.	.	.
cord-264884-ydkigome	98	1	These	these	DT
cord-264884-ydkigome	98	2	are	be	VBP
cord-264884-ydkigome	98	3	the	the	DT
cord-264884-ydkigome	98	4	products	product	NNS
cord-264884-ydkigome	98	5	of	of	IN
cord-264884-ydkigome	98	6	run	run	NN
cord-264884-ydkigome	98	7	away	away	RB
cord-264884-ydkigome	98	8	replicons	replicon	NNS
cord-264884-ydkigome	98	9	that	that	WDT
cord-264884-ydkigome	98	10	provide	provide	VBP
cord-264884-ydkigome	98	11	negative	negative	JJ
cord-264884-ydkigome	98	12	selection	selection	NN
cord-264884-ydkigome	98	13	to	to	TO
cord-264884-ydkigome	98	14	host	host	VB
cord-264884-ydkigome	98	15	survival	survival	NN
cord-264884-ydkigome	98	16	.	.	.
cord-264884-ydkigome	99	1	In	in	IN
cord-264884-ydkigome	99	2	this	this	DT
cord-264884-ydkigome	99	3	light	light	NN
cord-264884-ydkigome	99	4	,	,	,
cord-264884-ydkigome	99	5	the	the	DT
cord-264884-ydkigome	99	6	application	application	NN
cord-264884-ydkigome	99	7	of	of	IN
cord-264884-ydkigome	99	8	predator	predator	NN
cord-264884-ydkigome	99	9	-	-	HYPH
cord-264884-ydkigome	99	10	prey	prey	NN
cord-264884-ydkigome	99	11	based	base	VBN
cord-264884-ydkigome	99	12	mathematical	mathematical	JJ
cord-264884-ydkigome	99	13	models	model	NNS
cord-264884-ydkigome	99	14	has	have	VBZ
cord-264884-ydkigome	99	15	seemed	seem	VBN
cord-264884-ydkigome	99	16	most	most	RBS
cord-264884-ydkigome	99	17	appropriate	appropriate	JJ
cord-264884-ydkigome	99	18	.	.	.
cord-264884-ydkigome	100	1	With	with	IN
cord-264884-ydkigome	100	2	such	such	JJ
cord-264884-ydkigome	100	3	viral	viral	JJ
cord-264884-ydkigome	100	4	disease	disease	NN
cord-264884-ydkigome	100	5	,	,	,
cord-264884-ydkigome	100	6	variation	variation	NN
cord-264884-ydkigome	100	7	has	have	VBZ
cord-264884-ydkigome	100	8	long	long	RB
cord-264884-ydkigome	100	9	been	be	VBN
cord-264884-ydkigome	100	10	observed	observe	VBN
cord-264884-ydkigome	100	11	and	and	CC
cord-264884-ydkigome	100	12	was	be	VBD
cord-264884-ydkigome	100	13	initially	initially	RB
cord-264884-ydkigome	100	14	used	use	VBN
cord-264884-ydkigome	100	15	for	for	IN
cord-264884-ydkigome	100	16	the	the	DT
cord-264884-ydkigome	100	17	generation	generation	NN
cord-264884-ydkigome	100	18	of	of	IN
cord-264884-ydkigome	100	19	most	most	JJS
cord-264884-ydkigome	100	20	vaccines	vaccine	NNS
cord-264884-ydkigome	100	21	.	.	.
cord-264884-ydkigome	101	1	However	however	RB
cord-264884-ydkigome	101	2	,	,	,
cord-264884-ydkigome	101	3	this	this	DT
cord-264884-ydkigome	101	4	disease	disease	NN
cord-264884-ydkigome	101	5	-	-	HYPH
cord-264884-ydkigome	101	6	centric	centric	NN
cord-264884-ydkigome	101	7	view	view	NN
cord-264884-ydkigome	101	8	has	have	VBZ
cord-264884-ydkigome	101	9	also	also	RB
cord-264884-ydkigome	101	10	occluded	occlude	VBN
cord-264884-ydkigome	101	11	another	another	DT
cord-264884-ydkigome	101	12	more	more	RBR
cord-264884-ydkigome	101	13	prevalent	prevalent	JJ
cord-264884-ydkigome	101	14	virus	virus	NN
cord-264884-ydkigome	101	15	-	-	HYPH
cord-264884-ydkigome	101	16	host	host	NN
cord-264884-ydkigome	101	17	relationship	relationship	NN
cord-264884-ydkigome	101	18	.	.	.
cord-264884-ydkigome	102	1	For	for	IN
cord-264884-ydkigome	102	2	example	example	NN
cord-264884-ydkigome	102	3	the	the	DT
cord-264884-ydkigome	102	4	emergence	emergence	NN
cord-264884-ydkigome	102	5	of	of	IN
cord-264884-ydkigome	102	6	HIV-1	HIV-1	NNP
cord-264884-ydkigome	102	7	has	have	VBZ
cord-264884-ydkigome	102	8	led	lead	VBN
cord-264884-ydkigome	102	9	us	-PRON-	PRP
cord-264884-ydkigome	102	10	conclude	conclude	VB
cord-264884-ydkigome	102	11	that	that	IN
cord-264884-ydkigome	102	12	it	-PRON-	PRP
cord-264884-ydkigome	102	13	likely	likely	RB
cord-264884-ydkigome	102	14	evolved	evolve	VBD
cord-264884-ydkigome	102	15	from	from	IN
cord-264884-ydkigome	102	16	various	various	JJ
cord-264884-ydkigome	102	17	versions	version	NNS
cord-264884-ydkigome	102	18	of	of	IN
cord-264884-ydkigome	102	19	SIV	SIV	NNP
cord-264884-ydkigome	102	20	.	.	.
cord-264884-ydkigome	103	1	But	but	CC
cord-264884-ydkigome	103	2	SIV	SIV	NNP
cord-264884-ydkigome	103	3	is	be	VBZ
cord-264884-ydkigome	103	4	not	not	RB
cord-264884-ydkigome	103	5	pathogenic	pathogenic	JJ
cord-264884-ydkigome	103	6	in	in	IN
cord-264884-ydkigome	103	7	its	-PRON-	PRP$
cord-264884-ydkigome	103	8	native	native	JJ
cord-264884-ydkigome	103	9	African	african	JJ
cord-264884-ydkigome	103	10	primate	primate	NN
cord-264884-ydkigome	103	11	host	host	NN
cord-264884-ydkigome	103	12	.	.	.
cord-264884-ydkigome	104	1	Nor	nor	CC
cord-264884-ydkigome	104	2	does	do	VBZ
cord-264884-ydkigome	104	3	it	-PRON-	PRP
cord-264884-ydkigome	104	4	show	show	VB
cord-264884-ydkigome	104	5	the	the	DT
cord-264884-ydkigome	104	6	genetic	genetic	JJ
cord-264884-ydkigome	104	7	diversifi	diversifi	NN
cord-264884-ydkigome	104	8	cation	cation	NN
cord-264884-ydkigome	104	9	of	of	IN
cord-264884-ydkigome	104	10	HIV-1	HIV-1	NNP
cord-264884-ydkigome	104	11	in	in	IN
cord-264884-ydkigome	104	12	these	these	DT
cord-264884-ydkigome	104	13	native	native	JJ
cord-264884-ydkigome	104	14	primate	primate	JJ
cord-264884-ydkigome	104	15	hosts	host	NNS
cord-264884-ydkigome	104	16	.	.	.
cord-264884-ydkigome	105	1	It	-PRON-	PRP
cord-264884-ydkigome	105	2	is	be	VBZ
cord-264884-ydkigome	105	3	a	a	DT
cord-264884-ydkigome	105	4	silent	silent	JJ
cord-264884-ydkigome	105	5	,	,	,
cord-264884-ydkigome	105	6	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	105	7	infection	infection	NN
cord-264884-ydkigome	105	8	.	.	.
cord-264884-ydkigome	106	1	Genomic	genomic	JJ
cord-264884-ydkigome	106	2	and	and	CC
cord-264884-ydkigome	106	3	metagenomic	metagenomic	NNP
cord-264884-ydkigome	106	4	analysis	analysis	NN
cord-264884-ydkigome	106	5	now	now	RB
cord-264884-ydkigome	106	6	allows	allow	VBZ
cord-264884-ydkigome	106	7	us	-PRON-	PRP
cord-264884-ydkigome	106	8	to	to	TO
cord-264884-ydkigome	106	9	identify	identify	VB
cord-264884-ydkigome	106	10	many	many	JJ
cord-264884-ydkigome	106	11	more	more	RBR
cord-264884-ydkigome	106	12	silent	silent	JJ
cord-264884-ydkigome	106	13	,	,	,
cord-264884-ydkigome	106	14	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	106	15	viruses	virus	NNS
cord-264884-ydkigome	106	16	that	that	WDT
cord-264884-ydkigome	106	17	would	would	MD
cord-264884-ydkigome	106	18	not	not	RB
cord-264884-ydkigome	106	19	have	have	VB
cord-264884-ydkigome	106	20	previously	previously	RB
cord-264884-ydkigome	106	21	been	be	VBN
cord-264884-ydkigome	106	22	observed	observe	VBN
cord-264884-ydkigome	106	23	.	.	.
cord-264884-ydkigome	107	1	We	-PRON-	PRP
cord-264884-ydkigome	107	2	now	now	RB
cord-264884-ydkigome	107	3	know	know	VBP
cord-264884-ydkigome	107	4	of	of	IN
cord-264884-ydkigome	107	5	many	many	JJ
cord-264884-ydkigome	107	6	such	such	JJ
cord-264884-ydkigome	107	7	viruses	virus	NNS
cord-264884-ydkigome	107	8	that	that	WDT
cord-264884-ydkigome	107	9	are	be	VBP
cord-264884-ydkigome	107	10	prevalent	prevalent	JJ
cord-264884-ydkigome	107	11	in	in	IN
cord-264884-ydkigome	107	12	a	a	DT
cord-264884-ydkigome	107	13	specifi	specifi	NN
cord-264884-ydkigome	107	14	c	c	NN
cord-264884-ydkigome	107	15	host	host	NN
cord-264884-ydkigome	107	16	.	.	.
cord-264884-ydkigome	108	1	Evolutionary	evolutionary	JJ
cord-264884-ydkigome	108	2	biology	biology	NN
cord-264884-ydkigome	108	3	must	must	MD
cord-264884-ydkigome	108	4	escape	escape	VB
cord-264884-ydkigome	108	5	the	the	DT
cord-264884-ydkigome	108	6	confi	confi	NNP
cord-264884-ydkigome	108	7	nes	nes	NNP
cord-264884-ydkigome	108	8	of	of	IN
cord-264884-ydkigome	108	9	disease	disease	NNP
cord-264884-ydkigome	108	10	-	-	HYPH
cord-264884-ydkigome	108	11	centric	centric	NN
cord-264884-ydkigome	108	12	thinking	thinking	NN
cord-264884-ydkigome	108	13	and	and	CC
cord-264884-ydkigome	108	14	seek	seek	VB
cord-264884-ydkigome	108	15	to	to	TO
cord-264884-ydkigome	108	16	understand	understand	VB
cord-264884-ydkigome	108	17	these	these	DT
cord-264884-ydkigome	108	18	relationships	relationship	NNS
cord-264884-ydkigome	108	19	as	as	RB
cord-264884-ydkigome	108	20	well	well	RB
cord-264884-ydkigome	108	21	.	.	.
cord-264884-ydkigome	109	1	In	in	IN
cord-264884-ydkigome	109	2	the	the	DT
cord-264884-ydkigome	109	3	last	last	JJ
cord-264884-ydkigome	109	4	ten	ten	CD
cord-264884-ydkigome	109	5	years	year	NNS
cord-264884-ydkigome	109	6	I	-PRON-	PRP
cord-264884-ydkigome	109	7	have	have	VBP
cord-264884-ydkigome	109	8	attempted	attempt	VBN
cord-264884-ydkigome	109	9	to	to	TO
cord-264884-ydkigome	109	10	provide	provide	VB
cord-264884-ydkigome	109	11	another	another	DT
cord-264884-ydkigome	109	12	view	view	NN
cord-264884-ydkigome	109	13	concerning	concern	VBG
cord-264884-ydkigome	109	14	virus	virus	NN
cord-264884-ydkigome	109	15	-	-	HYPH
cord-264884-ydkigome	109	16	host	host	NN
cord-264884-ydkigome	109	17	evolution	evolution	NN
cord-264884-ydkigome	109	18	.	.	.
cord-264884-ydkigome	110	1	I	-PRON-	PRP
cord-264884-ydkigome	110	2	have	have	VBP
cord-264884-ydkigome	110	3	argued	argue	VBN
cord-264884-ydkigome	110	4	that	that	IN
cord-264884-ydkigome	110	5	viruses	virus	NNS
cord-264884-ydkigome	110	6	often	often	RB
cord-264884-ydkigome	110	7	attain	attain	VBP
cord-264884-ydkigome	110	8	evolutionary	evolutionary	JJ
cord-264884-ydkigome	110	9	stability	stability	NN
cord-264884-ydkigome	110	10	by	by	IN
cord-264884-ydkigome	110	11	species	species	NN
cord-264884-ydkigome	110	12	-	-	HYPH
cord-264884-ydkigome	110	13	specifi	specifi	NN
cord-264884-ydkigome	110	14	c	c	NN
cord-264884-ydkigome	110	15	persistence	persistence	NN
cord-264884-ydkigome	110	16	and	and	CC
cord-264884-ydkigome	110	17	that	that	IN
cord-264884-ydkigome	110	18	such	such	JJ
cord-264884-ydkigome	110	19	states	state	NNS
cord-264884-ydkigome	110	20	apply	apply	VBP
cord-264884-ydkigome	110	21	to	to	IN
cord-264884-ydkigome	110	22	all	all	DT
cord-264884-ydkigome	110	23	domains	domain	NNS
cord-264884-ydkigome	110	24	of	of	IN
cord-264884-ydkigome	110	25	life	life	NN
cord-264884-ydkigome	110	26	,	,	,
cord-264884-ydkigome	110	27	including	include	VBG
cord-264884-ydkigome	110	28	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	110	29	.	.	.
cord-264884-ydkigome	111	1	On	on	IN
cord-264884-ydkigome	111	2	an	an	DT
cord-264884-ydkigome	111	3	evolutionary	evolutionary	JJ
cord-264884-ydkigome	111	4	time	time	NN
cord-264884-ydkigome	111	5	-	-	HYPH
cord-264884-ydkigome	111	6	scale	scale	NN
cord-264884-ydkigome	111	7	,	,	,
cord-264884-ydkigome	111	8	the	the	DT
cord-264884-ydkigome	111	9	majority	majority	NN
cord-264884-ydkigome	111	10	of	of	IN
cord-264884-ydkigome	111	11	viral	viral	JJ
cord-264884-ydkigome	111	12	lineages	lineage	NNS
cord-264884-ydkigome	111	13	tend	tend	VBP
cord-264884-ydkigome	111	14	to	to	TO
cord-264884-ydkigome	111	15	exist	exist	VB
cord-264884-ydkigome	111	16	as	as	IN
cord-264884-ydkigome	111	17	species	species	NN
cord-264884-ydkigome	111	18	-	-	HYPH
cord-264884-ydkigome	111	19	specifi	specifi	NN
cord-264884-ydkigome	111	20	c	c	NN
cord-264884-ydkigome	111	21	persistent	persistent	NN
cord-264884-ydkigome	111	22	(	(	-LRB-
cord-264884-ydkigome	111	23	aka	aka	RB
cord-264884-ydkigome	111	24	temperate	temperate	JJ
cord-264884-ydkigome	111	25	,	,	,
cord-264884-ydkigome	111	26	latent	latent	JJ
cord-264884-ydkigome	111	27	,	,	,
cord-264884-ydkigome	111	28	and	and	CC
cord-264884-ydkigome	111	29	chronic	chronic	JJ
cord-264884-ydkigome	111	30	)	)	-RRB-
cord-264884-ydkigome	111	31	infections	infection	NNS
cord-264884-ydkigome	111	32	in	in	IN
cord-264884-ydkigome	111	33	which	which	WDT
cord-264884-ydkigome	111	34	individual	individual	JJ
cord-264884-ydkigome	111	35	hosts	host	NNS
cord-264884-ydkigome	111	36	will	will	MD
cord-264884-ydkigome	111	37	be	be	VB
cord-264884-ydkigome	111	38	colonized	colonize	VBN
cord-264884-ydkigome	111	39	by	by	IN
cord-264884-ydkigome	111	40	mostly	mostly	RB
cord-264884-ydkigome	111	41	silent	silent	JJ
cord-264884-ydkigome	111	42	(	(	-LRB-
cord-264884-ydkigome	111	43	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	111	44	)	)	-RRB-
cord-264884-ydkigome	111	45	viruses	virus	NNS
cord-264884-ydkigome	111	46	for	for	IN
cord-264884-ydkigome	111	47	the	the	DT
cord-264884-ydkigome	111	48	duration	duration	NN
cord-264884-ydkigome	111	49	of	of	IN
cord-264884-ydkigome	111	50	their	-PRON-	PRP$
cord-264884-ydkigome	111	51	life	life	NN
cord-264884-ydkigome	111	52	.	.	.
cord-264884-ydkigome	112	1	Such	such	JJ
cord-264884-ydkigome	112	2	persistence	persistence	NN
cord-264884-ydkigome	112	3	can	can	MD
cord-264884-ydkigome	112	4	have	have	VB
cord-264884-ydkigome	112	5	major	major	JJ
cord-264884-ydkigome	112	6	consequences	consequence	NNS
cord-264884-ydkigome	112	7	to	to	IN
cord-264884-ydkigome	112	8	the	the	DT
cord-264884-ydkigome	112	9	evolution	evolution	NN
cord-264884-ydkigome	112	10	of	of	IN
cord-264884-ydkigome	112	11	both	both	DT
cord-264884-ydkigome	112	12	virus	virus	NN
cord-264884-ydkigome	112	13	and	and	CC
cord-264884-ydkigome	112	14	host	host	NN
cord-264884-ydkigome	112	15	,	,	,
cord-264884-ydkigome	112	16	which	which	WDT
cord-264884-ydkigome	112	17	also	also	RB
cord-264884-ydkigome	112	18	leads	lead	VBZ
cord-264884-ydkigome	112	19	us	-PRON-	PRP
cord-264884-ydkigome	112	20	to	to	TO
cord-264884-ydkigome	112	21	more	more	RBR
cord-264884-ydkigome	112	22	directly	directly	RB
cord-264884-ydkigome	112	23	link	link	VB
cord-264884-ydkigome	112	24	virus	virus	NN
cord-264884-ydkigome	112	25	evolution	evolution	NN
cord-264884-ydkigome	112	26	to	to	IN
cord-264884-ydkigome	112	27	broader	broad	JJR
cord-264884-ydkigome	112	28	issues	issue	NNS
cord-264884-ydkigome	112	29	of	of	IN
cord-264884-ydkigome	112	30	host	host	NN
cord-264884-ydkigome	112	31	evolution	evolution	NN
cord-264884-ydkigome	112	32	.	.	.
cord-264884-ydkigome	113	1	It	-PRON-	PRP
cord-264884-ydkigome	113	2	is	be	VBZ
cord-264884-ydkigome	113	3	from	from	IN
cord-264884-ydkigome	113	4	this	this	DT
cord-264884-ydkigome	113	5	perspective	perspective	NN
cord-264884-ydkigome	113	6	that	that	IN
cord-264884-ydkigome	113	7	we	-PRON-	PRP
cord-264884-ydkigome	113	8	start	start	VBP
cord-264884-ydkigome	113	9	to	to	TO
cord-264884-ydkigome	113	10	clearly	clearly	RB
cord-264884-ydkigome	113	11	see	see	VB
cord-264884-ydkigome	113	12	that	that	IN
cord-264884-ydkigome	113	13	viruses	virus	NNS
cord-264884-ydkigome	113	14	indeed	indeed	RB
cord-264884-ydkigome	113	15	belong	belong	VBP
cord-264884-ydkigome	113	16	on	on	IN
cord-264884-ydkigome	113	17	the	the	DT
cord-264884-ydkigome	113	18	tree	tree	NN
cord-264884-ydkigome	113	19	of	of	IN
cord-264884-ydkigome	113	20	life	life	NN
cord-264884-ydkigome	113	21	as	as	IN
cord-264884-ydkigome	113	22	major	major	JJ
cord-264884-ydkigome	113	23	participants	participant	NNS
cord-264884-ydkigome	113	24	(	(	-LRB-
cord-264884-ydkigome	113	25	Villarreal	Villarreal	NNP
cord-264884-ydkigome	113	26	,	,	,
cord-264884-ydkigome	113	27	2005	2005	CD
cord-264884-ydkigome	114	1	(	(	-LRB-
cord-264884-ydkigome	114	2	Villarreal	Villarreal	NNP
cord-264884-ydkigome	114	3	,	,	,
cord-264884-ydkigome	114	4	,	,	,
cord-264884-ydkigome	114	5	2006	2006	CD
cord-264884-ydkigome	114	6	.	.	.
cord-264884-ydkigome	115	1	Persisting	persist	VBG
cord-264884-ydkigome	115	2	viruses	virus	NNS
cord-264884-ydkigome	115	3	are	be	VBP
cord-264884-ydkigome	115	4	not	not	RB
cord-264884-ydkigome	115	5	simply	simply	RB
cord-264884-ydkigome	115	6	agents	agent	NNS
cord-264884-ydkigome	115	7	responsible	responsible	JJ
cord-264884-ydkigome	115	8	for	for	IN
cord-264884-ydkigome	115	9	destruction	destruction	NN
cord-264884-ydkigome	115	10	of	of	IN
cord-264884-ydkigome	115	11	life	life	NN
cord-264884-ydkigome	115	12	,	,	,
cord-264884-ydkigome	115	13	but	but	CC
cord-264884-ydkigome	115	14	are	be	VBP
cord-264884-ydkigome	115	15	also	also	RB
cord-264884-ydkigome	115	16	agents	agent	NNS
cord-264884-ydkigome	115	17	that	that	WDT
cord-264884-ydkigome	115	18	create	create	VBP
cord-264884-ydkigome	115	19	genetic	genetic	JJ
cord-264884-ydkigome	115	20	novelty	novelty	NN
cord-264884-ydkigome	115	21	on	on	IN
cord-264884-ydkigome	115	22	a	a	DT
cord-264884-ydkigome	115	23	vast	vast	JJ
cord-264884-ydkigome	115	24	scale	scale	NN
cord-264884-ydkigome	115	25	that	that	WDT
cord-264884-ydkigome	115	26	infl	infl	NN
cord-264884-ydkigome	115	27	uences	uence	NNS
cord-264884-ydkigome	115	28	all	all	DT
cord-264884-ydkigome	115	29	life	life	NN
cord-264884-ydkigome	115	30	and	and	CC
cord-264884-ydkigome	115	31	promotes	promote	VBZ
cord-264884-ydkigome	115	32	symbiosis	symbiosis	NN
cord-264884-ydkigome	116	1	(	(	-LRB-
cord-264884-ydkigome	116	2	Marquez	Marquez	NNP
cord-264884-ydkigome	116	3	et	et	NNP
cord-264884-ydkigome	116	4	al	al	NNP
cord-264884-ydkigome	116	5	.	.	.
cord-264884-ydkigome	117	1	,	,	,
cord-264884-ydkigome	117	2	2007	2007	CD
cord-264884-ydkigome	117	3	;	;	:
cord-264884-ydkigome	117	4	Ryan	Ryan	NNP
cord-264884-ydkigome	117	5	,	,	,
cord-264884-ydkigome	117	6	2007	2007	CD
cord-264884-ydkigome	117	7	;	;	:
cord-264884-ydkigome	117	8	Villarreal	Villarreal	NNP
cord-264884-ydkigome	117	9	,	,	,
cord-264884-ydkigome	117	10	2007	2007	CD
cord-264884-ydkigome	117	11	)	)	-RRB-
cord-264884-ydkigome	117	12	.	.	.
cord-264884-ydkigome	118	1	The	the	DT
cord-264884-ydkigome	118	2	persistent	persistent	JJ
cord-264884-ydkigome	118	3	lifestyle	lifestyle	NN
cord-264884-ydkigome	118	4	of	of	IN
cord-264884-ydkigome	118	5	such	such	JJ
cord-264884-ydkigome	118	6	symbiotic	symbiotic	JJ
cord-264884-ydkigome	118	7	virus	virus	NN
cord-264884-ydkigome	118	8	-	-	HYPH
cord-264884-ydkigome	118	9	host	host	NN
cord-264884-ydkigome	118	10	relationships	relationship	NNS
cord-264884-ydkigome	118	11	is	be	VBZ
cord-264884-ydkigome	118	12	not	not	RB
cord-264884-ydkigome	118	13	simply	simply	RB
cord-264884-ydkigome	118	14	a	a	DT
cord-264884-ydkigome	118	15	less	less	RBR
cord-264884-ydkigome	118	16	effi	effi	NNP
cord-264884-ydkigome	118	17	cient	cient	NN
cord-264884-ydkigome	118	18	,	,	,
cord-264884-ydkigome	118	19	acute	acute	JJ
cord-264884-ydkigome	118	20	infection	infection	NN
cord-264884-ydkigome	118	21	;	;	,
cord-264884-ydkigome	118	22	nor	nor	CC
cord-264884-ydkigome	118	23	is	be	VBZ
cord-264884-ydkigome	118	24	it	-PRON-	PRP
cord-264884-ydkigome	118	25	simply	simply	RB
cord-264884-ydkigome	118	26	a	a	DT
cord-264884-ydkigome	118	27	"	"	``
cord-264884-ydkigome	118	28	reservoir	reservoir	NN
cord-264884-ydkigome	118	29	"	"	''
cord-264884-ydkigome	118	30	for	for	IN
cord-264884-ydkigome	118	31	acute	acute	JJ
cord-264884-ydkigome	118	32	virus	virus	NN
cord-264884-ydkigome	118	33	(	(	-LRB-
cord-264884-ydkigome	118	34	as	as	IN
cord-264884-ydkigome	118	35	epidemiologists	epidemiologist	NNS
cord-264884-ydkigome	118	36	are	be	VBP
cord-264884-ydkigome	118	37	prone	prone	JJ
cord-264884-ydkigome	118	38	to	to	TO
cord-264884-ydkigome	118	39	assert	assert	VB
cord-264884-ydkigome	118	40	)	)	-RRB-
cord-264884-ydkigome	118	41	.	.	.
cord-264884-ydkigome	119	1	Neither	neither	DT
cord-264884-ydkigome	119	2	can	can	MD
cord-264884-ydkigome	119	3	it	-PRON-	PRP
cord-264884-ydkigome	119	4	be	be	VB
cord-264884-ydkigome	119	5	attributable	attributable	JJ
cord-264884-ydkigome	119	6	to	to	IN
cord-264884-ydkigome	119	7	concepts	concept	NNS
cord-264884-ydkigome	119	8	of	of	IN
cord-264884-ydkigome	119	9	selfi	selfi	NNP
cord-264884-ydkigome	119	10	sh	sh	NNP
cord-264884-ydkigome	119	11	DNA	DNA	NNP
cord-264884-ydkigome	119	12	.	.	.
cord-264884-ydkigome	120	1	Persistence	persistence	NN
cord-264884-ydkigome	120	2	represents	represent	VBZ
cord-264884-ydkigome	120	3	a	a	DT
cord-264884-ydkigome	120	4	major	major	JJ
cord-264884-ydkigome	120	5	virus	virus	NN
cord-264884-ydkigome	120	6	life	life	NN
cord-264884-ydkigome	120	7	strategy	strategy	NN
cord-264884-ydkigome	120	8	that	that	WDT
cord-264884-ydkigome	120	9	is	be	VBZ
cord-264884-ydkigome	120	10	both	both	DT
cord-264884-ydkigome	120	11	fundamental	fundamental	JJ
cord-264884-ydkigome	120	12	and	and	CC
cord-264884-ydkigome	120	13	highly	highly	RB
cord-264884-ydkigome	120	14	adapted	adapt	VBN
cord-264884-ydkigome	120	15	.	.	.
cord-264884-ydkigome	121	1	It	-PRON-	PRP
cord-264884-ydkigome	121	2	has	have	VBZ
cord-264884-ydkigome	121	3	distinct	distinct	JJ
cord-264884-ydkigome	121	4	genetic	genetic	JJ
cord-264884-ydkigome	121	5	,	,	,
cord-264884-ydkigome	121	6	fi	fi	NN
cord-264884-ydkigome	121	7	tness	tness	NN
cord-264884-ydkigome	121	8	,	,	,
cord-264884-ydkigome	121	9	and	and	CC
cord-264884-ydkigome	121	10	evolutionary	evolutionary	JJ
cord-264884-ydkigome	121	11	characteristics	characteristic	NNS
cord-264884-ydkigome	121	12	that	that	WDT
cord-264884-ydkigome	121	13	require	require	VBP
cord-264884-ydkigome	121	14	intimate	intimate	JJ
cord-264884-ydkigome	121	15	,	,	,
cord-264884-ydkigome	121	16	host	host	NN
cord-264884-ydkigome	121	17	(	(	-LRB-
cord-264884-ydkigome	121	18	tissue)-specifi	tissue)-specifi	NNP
cord-264884-ydkigome	121	19	c	c	LS
cord-264884-ydkigome	121	20	viral	viral	JJ
cord-264884-ydkigome	121	21	strategies	strategy	NNS
cord-264884-ydkigome	121	22	and	and	CC
cord-264884-ydkigome	121	23	precise	precise	JJ
cord-264884-ydkigome	121	24	gene	gene	NN
cord-264884-ydkigome	121	25	functions	function	NNS
cord-264884-ydkigome	121	26	to	to	TO
cord-264884-ydkigome	121	27	attain	attain	VB
cord-264884-ydkigome	121	28	stable	stable	JJ
cord-264884-ydkigome	121	29	maintenance	maintenance	NN
cord-264884-ydkigome	121	30	in	in	IN
cord-264884-ydkigome	121	31	the	the	DT
cord-264884-ydkigome	121	32	presence	presence	NN
cord-264884-ydkigome	121	33	of	of	IN
cord-264884-ydkigome	121	34	immunity	immunity	NN
cord-264884-ydkigome	121	35	and	and	CC
cord-264884-ydkigome	121	36	to	to	TO
cord-264884-ydkigome	121	37	allow	allow	VB
cord-264884-ydkigome	121	38	biologically	biologically	RB
cord-264884-ydkigome	121	39	controlled	control	VBN
cord-264884-ydkigome	121	40	reactivation	reactivation	NN
cord-264884-ydkigome	121	41	.	.	.
cord-264884-ydkigome	122	1	Persistence	persistence	NN
cord-264884-ydkigome	122	2	also	also	RB
cord-264884-ydkigome	122	3	must	must	MD
cord-264884-ydkigome	122	4	resist	resist	VB
cord-264884-ydkigome	122	5	displacement	displacement	NN
cord-264884-ydkigome	122	6	by	by	IN
cord-264884-ydkigome	122	7	similar	similar	JJ
cord-264884-ydkigome	122	8	viruses	virus	NNS
cord-264884-ydkigome	122	9	and	and	CC
cord-264884-ydkigome	122	10	competitors	competitor	NNS
cord-264884-ydkigome	122	11	.	.	.
cord-264884-ydkigome	123	1	It	-PRON-	PRP
cord-264884-ydkigome	123	2	is	be	VBZ
cord-264884-ydkigome	123	3	virus	virus	NN
cord-264884-ydkigome	123	4	-	-	HYPH
cord-264884-ydkigome	123	5	host	host	NN
cord-264884-ydkigome	123	6	persistence	persistence	NN
cord-264884-ydkigome	123	7	that	that	WDT
cord-264884-ydkigome	123	8	provides	provide	VBZ
cord-264884-ydkigome	123	9	the	the	DT
cord-264884-ydkigome	123	10	thread	thread	NN
cord-264884-ydkigome	123	11	that	that	WDT
cord-264884-ydkigome	123	12	allows	allow	VBZ
cord-264884-ydkigome	123	13	us	-PRON-	PRP
cord-264884-ydkigome	123	14	to	to	TO
cord-264884-ydkigome	123	15	link	link	VB
cord-264884-ydkigome	123	16	these	these	DT
cord-264884-ydkigome	123	17	polyphyletic	polyphyletic	JJ
cord-264884-ydkigome	123	18	viral	viral	JJ
cord-264884-ydkigome	123	19	lineages	lineage	NNS
cord-264884-ydkigome	123	20	(	(	-LRB-
cord-264884-ydkigome	123	21	and	and	CC
cord-264884-ydkigome	123	22	their	-PRON-	PRP$
cord-264884-ydkigome	123	23	clouds	cloud	NNS
cord-264884-ydkigome	123	24	)	)	-RRB-
cord-264884-ydkigome	123	25	with	with	IN
cord-264884-ydkigome	123	26	the	the	DT
cord-264884-ydkigome	123	27	entire	entire	JJ
cord-264884-ydkigome	123	28	tree	tree	NN
cord-264884-ydkigome	123	29	of	of	IN
cord-264884-ydkigome	123	30	life	life	NN
cord-264884-ydkigome	123	31	.	.	.
cord-264884-ydkigome	124	1	In	in	IN
cord-264884-ydkigome	124	2	turn	turn	NN
cord-264884-ydkigome	124	3	,	,	,
cord-264884-ydkigome	124	4	this	this	DT
cord-264884-ydkigome	124	5	link	link	NN
cord-264884-ydkigome	124	6	identifi	identifi	NNP
cord-264884-ydkigome	124	7	es	es	NNP
cord-264884-ydkigome	124	8	a	a	DT
cord-264884-ydkigome	124	9	much	much	RB
cord-264884-ydkigome	124	10	more	more	RBR
cord-264884-ydkigome	124	11	fundamental	fundamental	JJ
cord-264884-ydkigome	124	12	role	role	NN
cord-264884-ydkigome	124	13	for	for	IN
cord-264884-ydkigome	124	14	viruses	virus	NNS
cord-264884-ydkigome	124	15	in	in	IN
cord-264884-ydkigome	124	16	the	the	DT
cord-264884-ydkigome	124	17	evolution	evolution	NN
cord-264884-ydkigome	124	18	of	of	IN
cord-264884-ydkigome	124	19	host	host	NN
cord-264884-ydkigome	124	20	,	,	,
cord-264884-ydkigome	124	21	visible	visible	JJ
cord-264884-ydkigome	124	22	from	from	IN
cord-264884-ydkigome	124	23	the	the	DT
cord-264884-ydkigome	124	24	very	very	RB
cord-264884-ydkigome	124	25	earliest	early	JJS
cord-264884-ydkigome	124	26	to	to	IN
cord-264884-ydkigome	124	27	the	the	DT
cord-264884-ydkigome	124	28	most	most	RBS
cord-264884-ydkigome	124	29	recent	recent	JJ
cord-264884-ydkigome	124	30	events	event	NNS
cord-264884-ydkigome	124	31	in	in	IN
cord-264884-ydkigome	124	32	host	host	NN
cord-264884-ydkigome	124	33	evolution	evolution	NN
cord-264884-ydkigome	124	34	.	.	.
cord-264884-ydkigome	125	1	It	-PRON-	PRP
cord-264884-ydkigome	125	2	is	be	VBZ
cord-264884-ydkigome	125	3	from	from	IN
cord-264884-ydkigome	125	4	such	such	JJ
cord-264884-ydkigome	125	5	species	specie	NNS
cord-264884-ydkigome	125	6	-	-	HYPH
cord-264884-ydkigome	125	7	specifi	specifi	NN
cord-264884-ydkigome	125	8	c	c	NN
cord-264884-ydkigome	125	9	persistent	persistent	JJ
cord-264884-ydkigome	125	10	states	state	NNS
cord-264884-ydkigome	125	11	that	that	IN
cord-264884-ydkigome	125	12	the	the	DT
cord-264884-ydkigome	125	13	large	large	JJ
cord-264884-ydkigome	125	14	majority	majority	NN
cord-264884-ydkigome	125	15	of	of	IN
cord-264884-ydkigome	125	16	acute	acute	JJ
cord-264884-ydkigome	125	17	diseases	disease	NNS
cord-264884-ydkigome	125	18	evolve	evolve	VBP
cord-264884-ydkigome	125	19	and	and	CC
cord-264884-ydkigome	125	20	emerge	emerge	VB
cord-264884-ydkigome	125	21	by	by	IN
cord-264884-ydkigome	125	22	various	various	JJ
cord-264884-ydkigome	125	23	mechanisms	mechanism	NNS
cord-264884-ydkigome	125	24	.	.	.
cord-264884-ydkigome	126	1	We	-PRON-	PRP
cord-264884-ydkigome	126	2	know	know	VBP
cord-264884-ydkigome	126	3	much	much	JJ
cord-264884-ydkigome	126	4	about	about	IN
cord-264884-ydkigome	126	5	virus	virus	NN
cord-264884-ydkigome	126	6	replication	replication	NN
cord-264884-ydkigome	126	7	and	and	CC
cord-264884-ydkigome	126	8	disease	disease	NN
cord-264884-ydkigome	126	9	.	.	.
cord-264884-ydkigome	127	1	However	however	RB
cord-264884-ydkigome	127	2	,	,	,
cord-264884-ydkigome	127	3	our	-PRON-	PRP$
cord-264884-ydkigome	127	4	understanding	understanding	NN
cord-264884-ydkigome	127	5	of	of	IN
cord-264884-ydkigome	127	6	the	the	DT
cord-264884-ydkigome	127	7	specifi	specifi	NN
cord-264884-ydkigome	127	8	c	c	NN
cord-264884-ydkigome	127	9	mechanisms	mechanism	NNS
cord-264884-ydkigome	127	10	of	of	IN
cord-264884-ydkigome	127	11	persistence	persistence	NN
cord-264884-ydkigome	127	12	is	be	VBZ
cord-264884-ydkigome	127	13	generally	generally	RB
cord-264884-ydkigome	127	14	poor	poor	JJ
cord-264884-ydkigome	127	15	.	.	.
cord-264884-ydkigome	128	1	Persistence	persistence	NN
cord-264884-ydkigome	128	2	is	be	VBZ
cord-264884-ydkigome	128	3	a	a	DT
cord-264884-ydkigome	128	4	generally	generally	RB
cord-264884-ydkigome	128	5	silent	silent	JJ
cord-264884-ydkigome	128	6	and	and	CC
cord-264884-ydkigome	128	7	inscrutable	inscrutable	JJ
cord-264884-ydkigome	128	8	state	state	NN
cord-264884-ydkigome	128	9	,	,	,
cord-264884-ydkigome	128	10	it	-PRON-	PRP
cord-264884-ydkigome	128	11	does	do	VBZ
cord-264884-ydkigome	128	12	not	not	RB
cord-264884-ydkigome	128	13	lend	lend	VB
cord-264884-ydkigome	128	14	itself	-PRON-	PRP
cord-264884-ydkigome	128	15	to	to	IN
cord-264884-ydkigome	128	16	in	in	IN
cord-264884-ydkigome	128	17	vitro	vitro	FW
cord-264884-ydkigome	128	18	or	or	CC
cord-264884-ydkigome	128	19	cell	cell	NN
cord-264884-ydkigome	128	20	culture	culture	NN
cord-264884-ydkigome	128	21	experimental	experimental	JJ
cord-264884-ydkigome	128	22	models	model	NNS
cord-264884-ydkigome	128	23	.	.	.
cord-264884-ydkigome	129	1	We	-PRON-	PRP
cord-264884-ydkigome	129	2	are	be	VBP
cord-264884-ydkigome	129	3	left	leave	VBN
cord-264884-ydkigome	129	4	with	with	IN
cord-264884-ydkigome	129	5	but	but	CC
cord-264884-ydkigome	129	6	a	a	DT
cord-264884-ydkigome	129	7	few	few	JJ
cord-264884-ydkigome	129	8	examples	example	NNS
cord-264884-ydkigome	129	9	from	from	IN
cord-264884-ydkigome	129	10	which	which	WDT
cord-264884-ydkigome	129	11	to	to	TO
cord-264884-ydkigome	129	12	attempt	attempt	VB
cord-264884-ydkigome	129	13	to	to	TO
cord-264884-ydkigome	129	14	extrapolate	extrapolate	VB
cord-264884-ydkigome	129	15	the	the	DT
cord-264884-ydkigome	129	16	possible	possible	JJ
cord-264884-ydkigome	129	17	existence	existence	NN
cord-264884-ydkigome	129	18	of	of	IN
cord-264884-ydkigome	129	19	general	general	JJ
cord-264884-ydkigome	129	20	relationships	relationship	NNS
cord-264884-ydkigome	129	21	.	.	.
cord-264884-ydkigome	130	1	The	the	DT
cord-264884-ydkigome	130	2	study	study	NN
cord-264884-ydkigome	130	3	of	of	IN
cord-264884-ydkigome	130	4	virus	virus	NN
cord-264884-ydkigome	130	5	evolution	evolution	NN
cord-264884-ydkigome	130	6	thus	thus	RB
cord-264884-ydkigome	130	7	struggles	struggle	VBZ
cord-264884-ydkigome	130	8	to	to	TO
cord-264884-ydkigome	130	9	incorporate	incorporate	VB
cord-264884-ydkigome	130	10	concepts	concept	NNS
cord-264884-ydkigome	130	11	of	of	IN
cord-264884-ydkigome	130	12	persistence	persistence	NN
cord-264884-ydkigome	130	13	.	.	.
cord-264884-ydkigome	131	1	Another	another	DT
cord-264884-ydkigome	131	2	recent	recent	JJ
cord-264884-ydkigome	131	3	and	and	CC
cord-264884-ydkigome	131	4	major	major	JJ
cord-264884-ydkigome	131	5	development	development	NN
cord-264884-ydkigome	131	6	in	in	IN
cord-264884-ydkigome	131	7	virus	virus	NN
cord-264884-ydkigome	131	8	evolution	evolution	NN
cord-264884-ydkigome	131	9	is	be	VBZ
cord-264884-ydkigome	131	10	the	the	DT
cord-264884-ydkigome	131	11	arrival	arrival	NN
cord-264884-ydkigome	131	12	of	of	IN
cord-264884-ydkigome	131	13	various	various	JJ
cord-264884-ydkigome	131	14	proposals	proposal	NNS
cord-264884-ydkigome	131	15	suggesting	suggest	VBG
cord-264884-ydkigome	131	16	that	that	IN
cord-264884-ydkigome	131	17	viruses	virus	NNS
cord-264884-ydkigome	131	18	have	have	VBP
cord-264884-ydkigome	131	19	been	be	VBN
cord-264884-ydkigome	131	20	involved	involve	VBN
cord-264884-ydkigome	131	21	in	in	IN
cord-264884-ydkigome	131	22	some	some	DT
cord-264884-ydkigome	131	23	major	major	JJ
cord-264884-ydkigome	131	24	innovation	innovation	NN
cord-264884-ydkigome	131	25	and	and	CC
cord-264884-ydkigome	131	26	transition	transition	NN
cord-264884-ydkigome	131	27	in	in	IN
cord-264884-ydkigome	131	28	the	the	DT
cord-264884-ydkigome	131	29	evolution	evolution	NN
cord-264884-ydkigome	131	30	of	of	IN
cord-264884-ydkigome	131	31	life	life	NN
cord-264884-ydkigome	131	32	.	.	.
cord-264884-ydkigome	132	1	In	in	IN
cord-264884-ydkigome	132	2	all	all	PDT
cord-264884-ydkigome	132	3	these	these	DT
cord-264884-ydkigome	132	4	proposals	proposal	NNS
cord-264884-ydkigome	132	5	,	,	,
cord-264884-ydkigome	132	6	however	however	RB
cord-264884-ydkigome	132	7	,	,	,
cord-264884-ydkigome	132	8	it	-PRON-	PRP
cord-264884-ydkigome	132	9	is	be	VBZ
cord-264884-ydkigome	132	10	necessary	necessary	JJ
cord-264884-ydkigome	132	11	that	that	IN
cord-264884-ydkigome	132	12	the	the	DT
cord-264884-ydkigome	132	13	virus	virus	NN
cord-264884-ydkigome	132	14	in	in	IN
cord-264884-ydkigome	132	15	question	question	NN
cord-264884-ydkigome	132	16	has	have	VBZ
cord-264884-ydkigome	132	17	attained	attain	VBN
cord-264884-ydkigome	132	18	a	a	DT
cord-264884-ydkigome	132	19	stable	stable	JJ
cord-264884-ydkigome	132	20	genomic	genomic	JJ
cord-264884-ydkigome	132	21	persistence	persistence	NN
cord-264884-ydkigome	132	22	with	with	IN
cord-264884-ydkigome	132	23	its	-PRON-	PRP$
cord-264884-ydkigome	132	24	host	host	NN
cord-264884-ydkigome	132	25	.	.	.
cord-264884-ydkigome	133	1	These	these	DT
cord-264884-ydkigome	133	2	evolutionary	evolutionary	JJ
cord-264884-ydkigome	133	3	events	event	NNS
cord-264884-ydkigome	133	4	thus	thus	RB
cord-264884-ydkigome	133	5	seem	seem	VBP
cord-264884-ydkigome	133	6	to	to	TO
cord-264884-ydkigome	133	7	be	be	VB
cord-264884-ydkigome	133	8	the	the	DT
cord-264884-ydkigome	133	9	products	product	NNS
cord-264884-ydkigome	133	10	of	of	IN
cord-264884-ydkigome	133	11	viral	viral	RB
cord-264884-ydkigome	133	12	-	-	HYPH
cord-264884-ydkigome	133	13	mediated	mediate	VBN
cord-264884-ydkigome	133	14	symbiogenesis	symbiogenesis	NN
cord-264884-ydkigome	133	15	of	of	IN
cord-264884-ydkigome	133	16	host	host	NN
cord-264884-ydkigome	133	17	(	(	-LRB-
cord-264884-ydkigome	133	18	Ryan	Ryan	NNP
cord-264884-ydkigome	133	19	,	,	,
cord-264884-ydkigome	133	20	2007	2007	CD
cord-264884-ydkigome	133	21	;	;	:
cord-264884-ydkigome	133	22	Villarreal	Villarreal	NNP
cord-264884-ydkigome	133	23	,	,	,
cord-264884-ydkigome	133	24	2007	2007	CD
cord-264884-ydkigome	133	25	)	)	-RRB-
cord-264884-ydkigome	133	26	.	.	.
cord-264884-ydkigome	134	1	Proposals	proposal	NNS
cord-264884-ydkigome	134	2	include	include	VBP
cord-264884-ydkigome	134	3	the	the	DT
cord-264884-ydkigome	134	4	possibility	possibility	NN
cord-264884-ydkigome	134	5	that	that	IN
cord-264884-ydkigome	134	6	viruses	virus	NNS
cord-264884-ydkigome	134	7	may	may	MD
cord-264884-ydkigome	134	8	have	have	VB
cord-264884-ydkigome	134	9	originated	originate	VBN
cord-264884-ydkigome	134	10	the	the	DT
cord-264884-ydkigome	134	11	DNA	dna	NN
cord-264884-ydkigome	134	12	replication	replication	NN
cord-264884-ydkigome	134	13	system	system	NN
cord-264884-ydkigome	134	14	of	of	IN
cord-264884-ydkigome	134	15	all	all	DT
cord-264884-ydkigome	134	16	three	three	CD
cord-264884-ydkigome	134	17	cellular	cellular	JJ
cord-264884-ydkigome	134	18	domains	domain	NNS
cord-264884-ydkigome	134	19	(	(	-LRB-
cord-264884-ydkigome	134	20	archaea	archaea	NNS
cord-264884-ydkigome	134	21	,	,	,
cord-264884-ydkigome	134	22	bacteria	bacteria	NNS
cord-264884-ydkigome	134	23	,	,	,
cord-264884-ydkigome	134	24	eukarya	eukarya	NNP
cord-264884-ydkigome	134	25	)	)	-RRB-
cord-264884-ydkigome	134	26	of	of	IN
cord-264884-ydkigome	134	27	life	life	NN
cord-264884-ydkigome	134	28	(	(	-LRB-
cord-264884-ydkigome	134	29	Forterre	Forterre	NNP
cord-264884-ydkigome	134	30	,	,	,
cord-264884-ydkigome	134	31	1999	1999	CD
cord-264884-ydkigome	134	32	(	(	-LRB-
cord-264884-ydkigome	134	33	Forterre	Forterre	NNP
cord-264884-ydkigome	134	34	,	,	,
cord-264884-ydkigome	134	35	,	,	,
cord-264884-ydkigome	134	36	2005	2005	CD
cord-264884-ydkigome	134	37	(	(	-LRB-
cord-264884-ydkigome	134	38	Forterre	Forterre	NNP
cord-264884-ydkigome	134	39	,	,	,
cord-264884-ydkigome	134	40	,	,	,
cord-264884-ydkigome	134	41	2006a	2006a	CD
cord-264884-ydkigome	134	42	(	(	-LRB-
cord-264884-ydkigome	134	43	Forterre	Forterre	NNP
cord-264884-ydkigome	134	44	,	,	,
cord-264884-ydkigome	134	45	,	,	,
cord-264884-ydkigome	134	46	2006b	2006b	CD
cord-264884-ydkigome	134	47	Filee	Filee	NNP
cord-264884-ydkigome	134	48	et	et	NNP
cord-264884-ydkigome	134	49	al	al	NNP
cord-264884-ydkigome	134	50	.	.	NNP
cord-264884-ydkigome	134	51	,	,	,
cord-264884-ydkigome	134	52	2003	2003	CD
cord-264884-ydkigome	134	53	;	;	:
cord-264884-ydkigome	134	54	Forterre	Forterre	NNP
cord-264884-ydkigome	134	55	et	et	NNP
cord-264884-ydkigome	134	56	al	al	NNP
cord-264884-ydkigome	134	57	.	.	NNP
cord-264884-ydkigome	134	58	,	,	,
cord-264884-ydkigome	134	59	2007	2007	CD
cord-264884-ydkigome	134	60	)	)	-RRB-
cord-264884-ydkigome	134	61	.	.	.
cord-264884-ydkigome	135	1	The	the	DT
cord-264884-ydkigome	135	2	discovery	discovery	NN
cord-264884-ydkigome	135	3	and	and	CC
cord-264884-ydkigome	135	4	analysis	analysis	NN
cord-264884-ydkigome	135	5	of	of	IN
cord-264884-ydkigome	135	6	the	the	DT
cord-264884-ydkigome	135	7	largest	large	JJS
cord-264884-ydkigome	135	8	DNA	dna	NN
cord-264884-ydkigome	135	9	virus	virus	NN
cord-264884-ydkigome	135	10	(	(	-LRB-
cord-264884-ydkigome	135	11	1200	1200	CD
cord-264884-ydkigome	135	12	ORF	ORF	NNP
cord-264884-ydkigome	135	13	mimivirus	mimivirus	NNP
cord-264884-ydkigome	135	14	)	)	-RRB-
cord-264884-ydkigome	135	15	,	,	,
cord-264884-ydkigome	135	16	a	a	DT
cord-264884-ydkigome	135	17	lytic	lytic	JJ
cord-264884-ydkigome	135	18	cytoplasmic	cytoplasmic	JJ
cord-264884-ydkigome	135	19	virus	virus	NN
cord-264884-ydkigome	135	20	of	of	IN
cord-264884-ydkigome	135	21	amebae	amebae	NNP
cord-264884-ydkigome	135	22	(	(	-LRB-
cord-264884-ydkigome	135	23	a	a	DT
cord-264884-ydkigome	135	24	distant	distant	JJ
cord-264884-ydkigome	135	25	relative	relative	NN
cord-264884-ydkigome	135	26	of	of	IN
cord-264884-ydkigome	135	27	phycodnavirus	phycodnavirus	NNP
cord-264884-ydkigome	135	28	and	and	CC
cord-264884-ydkigome	135	29	poxviruses	poxviruses	NNP
cord-264884-ydkigome	135	30	)	)	-RRB-
cord-264884-ydkigome	135	31	,	,	,
cord-264884-ydkigome	135	32	has	have	VBZ
cord-264884-ydkigome	135	33	also	also	RB
cord-264884-ydkigome	135	34	led	lead	VBN
cord-264884-ydkigome	135	35	to	to	IN
cord-264884-ydkigome	135	36	proposals	proposal	NNS
cord-264884-ydkigome	135	37	that	that	IN
cord-264884-ydkigome	135	38	this	this	DT
cord-264884-ydkigome	135	39	virus	virus	NN
cord-264884-ydkigome	135	40	lineage	lineage	NN
cord-264884-ydkigome	135	41	may	may	MD
cord-264884-ydkigome	135	42	represent	represent	VB
cord-264884-ydkigome	135	43	an	an	DT
cord-264884-ydkigome	135	44	ancient	ancient	JJ
cord-264884-ydkigome	135	45	fourth	fourth	JJ
cord-264884-ydkigome	135	46	domain	domain	NN
cord-264884-ydkigome	135	47	of	of	IN
cord-264884-ydkigome	135	48	life	life	NN
cord-264884-ydkigome	135	49	(	(	-LRB-
cord-264884-ydkigome	135	50	Raoult	Raoult	NNP
cord-264884-ydkigome	135	51	et	et	FW
cord-264884-ydkigome	135	52	al	al	NNP
cord-264884-ydkigome	135	53	.	.	NNP
cord-264884-ydkigome	135	54	,	,	,
cord-264884-ydkigome	135	55	2004	2004	CD
cord-264884-ydkigome	135	56	;	;	:
cord-264884-ydkigome	135	57	Desjardins	Desjardins	NNP
cord-264884-ydkigome	135	58	et	et	FW
cord-264884-ydkigome	135	59	al	al	NNP
cord-264884-ydkigome	135	60	.	.	NNP
cord-264884-ydkigome	135	61	,	,	,
cord-264884-ydkigome	135	62	2005	2005	CD
cord-264884-ydkigome	135	63	;	;	:
cord-264884-ydkigome	136	1	Claverie	Claverie	NNP
cord-264884-ydkigome	136	2	et	et	NNP
cord-264884-ydkigome	136	3	al	al	NNP
cord-264884-ydkigome	136	4	.	.	NNP
cord-264884-ydkigome	136	5	,	,	,
cord-264884-ydkigome	136	6	2006	2006	CD
cord-264884-ydkigome	136	7	)	)	-RRB-
cord-264884-ydkigome	136	8	.	.	.
cord-264884-ydkigome	137	1	It	-PRON-	PRP
cord-264884-ydkigome	137	2	is	be	VBZ
cord-264884-ydkigome	137	3	interesting	interesting	JJ
cord-264884-ydkigome	137	4	that	that	IN
cord-264884-ydkigome	137	5	in	in	IN
cord-264884-ydkigome	137	6	an	an	DT
cord-264884-ydkigome	137	7	initial	initial	JJ
cord-264884-ydkigome	137	8	structural	structural	JJ
cord-264884-ydkigome	137	9	analysis	analysis	NN
cord-264884-ydkigome	137	10	,	,	,
cord-264884-ydkigome	137	11	the	the	DT
cord-264884-ydkigome	137	12	large	large	JJ
cord-264884-ydkigome	137	13	complex	complex	JJ
cord-264884-ydkigome	137	14	replication	replication	NN
cord-264884-ydkigome	137	15	centers	center	NNS
cord-264884-ydkigome	137	16	for	for	IN
cord-264884-ydkigome	137	17	mimivirus	mimivirus	NNP
cord-264884-ydkigome	137	18	were	be	VBD
cord-264884-ydkigome	137	19	confused	confuse	VBN
cord-264884-ydkigome	137	20	with	with	IN
cord-264884-ydkigome	137	21	the	the	DT
cord-264884-ydkigome	137	22	host	host	NN
cord-264884-ydkigome	137	23	nucleus	nucleus	NN
cord-264884-ydkigome	137	24	(	(	-LRB-
cord-264884-ydkigome	137	25	Suzan	Suzan	NNP
cord-264884-ydkigome	137	26	-	-	HYPH
cord-264884-ydkigome	137	27	Monti	Monti	NNP
cord-264884-ydkigome	137	28	et	et	NNP
cord-264884-ydkigome	137	29	al	al	NNP
cord-264884-ydkigome	137	30	.	.	NNP
cord-264884-ydkigome	137	31	,	,	,
cord-264884-ydkigome	137	32	2007	2007	CD
cord-264884-ydkigome	137	33	)	)	-RRB-
cord-264884-ydkigome	137	34	.	.	.
cord-264884-ydkigome	138	1	Thus	thus	RB
cord-264884-ydkigome	138	2	,	,	,
cord-264884-ydkigome	138	3	it	-PRON-	PRP
cord-264884-ydkigome	138	4	seems	seem	VBZ
cord-264884-ydkigome	138	5	relevant	relevant	JJ
cord-264884-ydkigome	138	6	that	that	IN
cord-264884-ydkigome	138	7	others	other	NNS
cord-264884-ydkigome	138	8	have	have	VBP
cord-264884-ydkigome	138	9	proposed	propose	VBN
cord-264884-ydkigome	138	10	that	that	IN
cord-264884-ydkigome	138	11	a	a	DT
cord-264884-ydkigome	138	12	distant	distant	JJ
cord-264884-ydkigome	138	13	relative	relative	NN
cord-264884-ydkigome	138	14	of	of	IN
cord-264884-ydkigome	138	15	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	138	16	and	and	CC
cord-264884-ydkigome	138	17	poxviruses	poxvirus	NNS
cord-264884-ydkigome	138	18	may	may	MD
cord-264884-ydkigome	138	19	have	have	VB
cord-264884-ydkigome	138	20	originated	originate	VBN
cord-264884-ydkigome	138	21	the	the	DT
cord-264884-ydkigome	138	22	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	138	23	nucleus	nucleus	NN
cord-264884-ydkigome	138	24	(	(	-LRB-
cord-264884-ydkigome	138	25	Villarreal	Villarreal	NNP
cord-264884-ydkigome	138	26	,	,	,
cord-264884-ydkigome	138	27	1999	1999	CD
cord-264884-ydkigome	138	28	;	;	:
cord-264884-ydkigome	138	29	Villarreal	Villarreal	NNP
cord-264884-ydkigome	138	30	and	and	CC
cord-264884-ydkigome	138	31	DeFilippis	DeFilippis	NNP
cord-264884-ydkigome	138	32	,	,	,
cord-264884-ydkigome	138	33	2000	2000	CD
cord-264884-ydkigome	138	34	;	;	:
cord-264884-ydkigome	138	35	Bell	Bell	NNP
cord-264884-ydkigome	138	36	,	,	,
cord-264884-ydkigome	138	37	2001	2001	CD
cord-264884-ydkigome	138	38	Bell	Bell	NNP
cord-264884-ydkigome	138	39	,	,	,
cord-264884-ydkigome	138	40	,	,	,
cord-264884-ydkigome	138	41	2006	2006	CD
cord-264884-ydkigome	138	42	Takemura	Takemura	NNP
cord-264884-ydkigome	138	43	,	,	,
cord-264884-ydkigome	138	44	2001	2001	CD
cord-264884-ydkigome	138	45	)	)	-RRB-
cord-264884-ydkigome	138	46	.	.	.
cord-264884-ydkigome	139	1	Such	such	JJ
cord-264884-ydkigome	139	2	proposals	proposal	NNS
cord-264884-ydkigome	139	3	,	,	,
cord-264884-ydkigome	139	4	although	although	IN
cord-264884-ydkigome	139	5	consistent	consistent	JJ
cord-264884-ydkigome	139	6	with	with	IN
cord-264884-ydkigome	139	7	various	various	JJ
cord-264884-ydkigome	139	8	observations	observation	NNS
cord-264884-ydkigome	139	9	,	,	,
cord-264884-ydkigome	139	10	however	however	RB
cord-264884-ydkigome	139	11	,	,	,
cord-264884-ydkigome	139	12	remain	remain	VBP
cord-264884-ydkigome	139	13	outside	outside	RB
cord-264884-ydkigome	139	14	of	of	IN
cord-264884-ydkigome	139	15	the	the	DT
cord-264884-ydkigome	139	16	consensus	consensus	NN
cord-264884-ydkigome	139	17	of	of	IN
cord-264884-ydkigome	139	18	most	most	JJS
cord-264884-ydkigome	139	19	evolutionary	evolutionary	JJ
cord-264884-ydkigome	139	20	biologists	biologist	NNS
cord-264884-ydkigome	139	21	.	.	.
cord-264884-ydkigome	140	1	Nevertheless	nevertheless	RB
cord-264884-ydkigome	140	2	,	,	,
cord-264884-ydkigome	140	3	numerous	numerous	JJ
cord-264884-ydkigome	140	4	other	other	JJ
cord-264884-ydkigome	140	5	observations	observation	NNS
cord-264884-ydkigome	140	6	continue	continue	VBP
cord-264884-ydkigome	140	7	to	to	TO
cord-264884-ydkigome	140	8	suggest	suggest	VB
cord-264884-ydkigome	140	9	viral	viral	JJ
cord-264884-ydkigome	140	10	involvement	involvement	NN
cord-264884-ydkigome	140	11	in	in	IN
cord-264884-ydkigome	140	12	other	other	JJ
cord-264884-ydkigome	140	13	major	major	JJ
cord-264884-ydkigome	140	14	host	host	NN
cord-264884-ydkigome	140	15	innovations	innovation	NNS
cord-264884-ydkigome	140	16	,	,	,
cord-264884-ydkigome	140	17	such	such	JJ
cord-264884-ydkigome	140	18	as	as	IN
cord-264884-ydkigome	140	19	a	a	DT
cord-264884-ydkigome	140	20	viral	viral	JJ
cord-264884-ydkigome	140	21	origin	origin	NN
cord-264884-ydkigome	140	22	of	of	IN
cord-264884-ydkigome	140	23	RAG1/2	RAG1/2	NNP
cord-264884-ydkigome	140	24	of	of	IN
cord-264884-ydkigome	140	25	the	the	DT
cord-264884-ydkigome	140	26	adaptive	adaptive	JJ
cord-264884-ydkigome	140	27	immune	immune	JJ
cord-264884-ydkigome	140	28	system	system	NN
cord-264884-ydkigome	141	1	(	(	-LRB-
cord-264884-ydkigome	141	2	Dreyfus	Dreyfus	NNP
cord-264884-ydkigome	141	3	et	et	NNP
cord-264884-ydkigome	141	4	al	al	NNP
cord-264884-ydkigome	141	5	.	.	NNP
cord-264884-ydkigome	141	6	,	,	,
cord-264884-ydkigome	142	1	1999	1999	CD
cord-264884-ydkigome	142	2	Kapitonov	Kapitonov	NNP
cord-264884-ydkigome	142	3	and	and	CC
cord-264884-ydkigome	142	4	Jurka	Jurka	NNP
cord-264884-ydkigome	142	5	,	,	,
cord-264884-ydkigome	142	6	2005	2005	CD
cord-264884-ydkigome	142	7	;	;	:
cord-264884-ydkigome	142	8	Fugmann	Fugmann	NNP
cord-264884-ydkigome	142	9	et	et	NNP
cord-264884-ydkigome	142	10	al	al	NNP
cord-264884-ydkigome	142	11	.	.	NNP
cord-264884-ydkigome	142	12	,	,	,
cord-264884-ydkigome	142	13	2006	2006	CD
cord-264884-ydkigome	142	14	)	)	-RRB-
cord-264884-ydkigome	142	15	or	or	CC
cord-264884-ydkigome	142	16	the	the	DT
cord-264884-ydkigome	142	17	role	role	NN
cord-264884-ydkigome	142	18	of	of	IN
cord-264884-ydkigome	142	19	endogenous	endogenous	JJ
cord-264884-ydkigome	142	20	retroviruses	retrovirus	NNS
cord-264884-ydkigome	142	21	(	(	-LRB-
cord-264884-ydkigome	142	22	ERVs	erv	NNS
cord-264884-ydkigome	142	23	)	)	-RRB-
cord-264884-ydkigome	142	24	in	in	IN
cord-264884-ydkigome	142	25	the	the	DT
cord-264884-ydkigome	142	26	evolution	evolution	NN
cord-264884-ydkigome	142	27	of	of	IN
cord-264884-ydkigome	142	28	the	the	DT
cord-264884-ydkigome	142	29	placenta	placenta	NN
cord-264884-ydkigome	142	30	(	(	-LRB-
cord-264884-ydkigome	142	31	Villarreal	Villarreal	NNP
cord-264884-ydkigome	142	32	and	and	CC
cord-264884-ydkigome	142	33	Villareal	Villareal	NNP
cord-264884-ydkigome	142	34	,	,	,
cord-264884-ydkigome	142	35	1997	1997	CD
cord-264884-ydkigome	142	36	;	;	:
cord-264884-ydkigome	142	37	Harris	Harris	NNP
cord-264884-ydkigome	142	38	,	,	,
cord-264884-ydkigome	142	39	1998	1998	CD
cord-264884-ydkigome	142	40	;	;	:
cord-264884-ydkigome	142	41	Blond	Blond	NNP
cord-264884-ydkigome	142	42	et	et	NNP
cord-264884-ydkigome	142	43	al	al	NNP
cord-264884-ydkigome	142	44	.	.	NNP
cord-264884-ydkigome	142	45	,	,	,
cord-264884-ydkigome	142	46	2000	2000	CD
cord-264884-ydkigome	142	47	;	;	:
cord-264884-ydkigome	142	48	Mi	Mi	NNP
cord-264884-ydkigome	142	49	et	et	NNP
cord-264884-ydkigome	142	50	al	al	NNP
cord-264884-ydkigome	142	51	.	.	NNP
cord-264884-ydkigome	142	52	,	,	,
cord-264884-ydkigome	142	53	2000	2000	CD
cord-264884-ydkigome	142	54	;	;	:
cord-264884-ydkigome	143	1	Dupressoir	Dupressoir	NNP
cord-264884-ydkigome	143	2	et	et	FW
cord-264884-ydkigome	143	3	al	al	NNP
cord-264884-ydkigome	143	4	.	.	NNP
cord-264884-ydkigome	143	5	,	,	,
cord-264884-ydkigome	143	6	2005	2005	CD
cord-264884-ydkigome	143	7	;	;	:
cord-264884-ydkigome	143	8	Caceres	Caceres	NNP
cord-264884-ydkigome	143	9	and	and	CC
cord-264884-ydkigome	143	10	Thomas	Thomas	NNP
cord-264884-ydkigome	143	11	,	,	,
cord-264884-ydkigome	143	12	2006	2006	CD
cord-264884-ydkigome	143	13	)	)	-RRB-
cord-264884-ydkigome	143	14	.	.	.
cord-264884-ydkigome	144	1	Such	such	JJ
cord-264884-ydkigome	144	2	possible	possible	JJ
cord-264884-ydkigome	144	3	roles	role	NNS
cord-264884-ydkigome	144	4	for	for	IN
cord-264884-ydkigome	144	5	viruses	virus	NNS
cord-264884-ydkigome	144	6	in	in	IN
cord-264884-ydkigome	144	7	host	host	NN
cord-264884-ydkigome	144	8	evolution	evolution	NN
cord-264884-ydkigome	144	9	are	be	VBP
cord-264884-ydkigome	144	10	at	at	IN
cord-264884-ydkigome	144	11	odds	odd	NNS
cord-264884-ydkigome	144	12	with	with	IN
cord-264884-ydkigome	144	13	accepted	accept	VBN
cord-264884-ydkigome	144	14	views	view	NNS
cord-264884-ydkigome	144	15	of	of	IN
cord-264884-ydkigome	144	16	virus	virus	NN
cord-264884-ydkigome	144	17	-	-	HYPH
cord-264884-ydkigome	144	18	host	host	NN
cord-264884-ydkigome	144	19	relationships	relationship	NNS
cord-264884-ydkigome	144	20	,	,	,
cord-264884-ydkigome	144	21	but	but	CC
cord-264884-ydkigome	144	22	might	may	MD
cord-264884-ydkigome	144	23	be	be	VB
cord-264884-ydkigome	144	24	the	the	DT
cord-264884-ydkigome	144	25	products	product	NNS
cord-264884-ydkigome	144	26	of	of	IN
cord-264884-ydkigome	144	27	viral	viral	JJ
cord-264884-ydkigome	144	28	symbiogenesis	symbiogenesis	NNP
cord-264884-ydkigome	144	29	.	.	.
cord-264884-ydkigome	145	1	The	the	DT
cord-264884-ydkigome	145	2	metagenomic	metagenomic	FW
cord-264884-ydkigome	145	3	viral	viral	JJ
cord-264884-ydkigome	145	4	measurements	measurement	NNS
cord-264884-ydkigome	145	5	mentioned	mention	VBN
cord-264884-ydkigome	145	6	above	above	RB
cord-264884-ydkigome	145	7	for	for	IN
cord-264884-ydkigome	145	8	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	145	9	DNA	dna	NN
cord-264884-ydkigome	145	10	viruses	virus	NNS
cord-264884-ydkigome	145	11	,	,	,
cord-264884-ydkigome	145	12	along	along	IN
cord-264884-ydkigome	145	13	with	with	IN
cord-264884-ydkigome	145	14	the	the	DT
cord-264884-ydkigome	145	15	increasing	increase	VBG
cord-264884-ydkigome	145	16	realization	realization	NN
cord-264884-ydkigome	145	17	that	that	IN
cord-264884-ydkigome	145	18	viruses	virus	NNS
cord-264884-ydkigome	145	19	and	and	CC
cord-264884-ydkigome	145	20	host	host	NN
cord-264884-ydkigome	145	21	can	can	MD
cord-264884-ydkigome	145	22	co	co	VB
cord-264884-ydkigome	145	23	-	-	VB
cord-264884-ydkigome	145	24	evolve	evolve	VB
cord-264884-ydkigome	145	25	,	,	,
cord-264884-ydkigome	145	26	has	have	VBZ
cord-264884-ydkigome	145	27	led	lead	VBN
cord-264884-ydkigome	145	28	to	to	IN
cord-264884-ydkigome	145	29	various	various	JJ
cord-264884-ydkigome	145	30	calls	call	NNS
cord-264884-ydkigome	145	31	that	that	IN
cord-264884-ydkigome	145	32	a	a	DT
cord-264884-ydkigome	145	33	viral	viral	JJ
cord-264884-ydkigome	145	34	tree	tree	NN
cord-264884-ydkigome	145	35	of	of	IN
cord-264884-ydkigome	145	36	life	life	NN
cord-264884-ydkigome	145	37	needs	need	VBZ
cord-264884-ydkigome	145	38	to	to	TO
cord-264884-ydkigome	145	39	be	be	VB
cord-264884-ydkigome	145	40	considered	consider	VBN
cord-264884-ydkigome	145	41	and	and	CC
cord-264884-ydkigome	145	42	developed	develop	VBN
cord-264884-ydkigome	145	43	(	(	-LRB-
cord-264884-ydkigome	145	44	Forterre	Forterre	NNP
cord-264884-ydkigome	145	45	,	,	,
cord-264884-ydkigome	145	46	2003	2003	CD
cord-264884-ydkigome	145	47	;	;	:
cord-264884-ydkigome	145	48	Villarreal	Villarreal	NNP
cord-264884-ydkigome	145	49	,	,	,
cord-264884-ydkigome	145	50	2006	2006	CD
cord-264884-ydkigome	145	51	;	;	:
cord-264884-ydkigome	145	52	Filee	Filee	NNP
cord-264884-ydkigome	145	53	et	et	NNP
cord-264884-ydkigome	145	54	al	al	NNP
cord-264884-ydkigome	145	55	.	.	NNP
cord-264884-ydkigome	145	56	,	,	,
cord-264884-ydkigome	145	57	2006b	2006b	CD
cord-264884-ydkigome	145	58	)	)	-RRB-
cord-264884-ydkigome	145	59	.	.	.
cord-264884-ydkigome	146	1	A	a	DT
cord-264884-ydkigome	146	2	virosphere	virosphere	NN
cord-264884-ydkigome	146	3	clearly	clearly	RB
cord-264884-ydkigome	146	4	exists	exist	VBZ
cord-264884-ydkigome	146	5	but	but	CC
cord-264884-ydkigome	146	6	its	-PRON-	PRP$
cord-264884-ydkigome	146	7	nature	nature	NN
cord-264884-ydkigome	146	8	and	and	CC
cord-264884-ydkigome	146	9	boundaries	boundary	NNS
cord-264884-ydkigome	146	10	are	be	VBP
cord-264884-ydkigome	146	11	not	not	RB
cord-264884-ydkigome	146	12	so	so	RB
cord-264884-ydkigome	146	13	clear	clear	JJ
cord-264884-ydkigome	146	14	.	.	.
cord-264884-ydkigome	147	1	Multiple	multiple	JJ
cord-264884-ydkigome	147	2	viral	viral	JJ
cord-264884-ydkigome	147	3	origins	origin	NNS
cord-264884-ydkigome	147	4	,	,	,
cord-264884-ydkigome	147	5	their	-PRON-	PRP$
cord-264884-ydkigome	147	6	diversity	diversity	NN
cord-264884-ydkigome	147	7	and	and	CC
cord-264884-ydkigome	147	8	numerical	numerical	JJ
cord-264884-ydkigome	147	9	dominance	dominance	NN
cord-264884-ydkigome	147	10	in	in	IN
cord-264884-ydkigome	147	11	distinct	distinct	JJ
cord-264884-ydkigome	147	12	and	and	CC
cord-264884-ydkigome	147	13	sometimes	sometimes	RB
cord-264884-ydkigome	147	14	harsh	harsh	JJ
cord-264884-ydkigome	147	15	environments	environment	NNS
cord-264884-ydkigome	147	16	as	as	RB
cord-264884-ydkigome	147	17	well	well	RB
cord-264884-ydkigome	147	18	as	as	IN
cord-264884-ydkigome	147	19	their	-PRON-	PRP$
cord-264884-ydkigome	147	20	presence	presence	NN
cord-264884-ydkigome	147	21	in	in	IN
cord-264884-ydkigome	147	22	host	host	NN
cord-264884-ydkigome	147	23	genomes	genome	NNS
cord-264884-ydkigome	147	24	suggest	suggest	VBP
cord-264884-ydkigome	147	25	that	that	IN
cord-264884-ydkigome	147	26	any	any	DT
cord-264884-ydkigome	147	27	viral	viral	JJ
cord-264884-ydkigome	147	28	tree	tree	NN
cord-264884-ydkigome	147	29	of	of	IN
cord-264884-ydkigome	147	30	life	life	NN
cord-264884-ydkigome	147	31	will	will	MD
cord-264884-ydkigome	147	32	be	be	VB
cord-264884-ydkigome	147	33	huge	huge	JJ
cord-264884-ydkigome	147	34	,	,	,
cord-264884-ydkigome	147	35	multidimensional	multidimensional	JJ
cord-264884-ydkigome	147	36	,	,	,
cord-264884-ydkigome	147	37	and	and	CC
cord-264884-ydkigome	147	38	connected	connect	VBN
cord-264884-ydkigome	147	39	to	to	IN
cord-264884-ydkigome	147	40	the	the	DT
cord-264884-ydkigome	147	41	host	host	NN
cord-264884-ydkigome	147	42	tree	tree	NN
cord-264884-ydkigome	147	43	of	of	IN
cord-264884-ydkigome	147	44	life	life	NN
cord-264884-ydkigome	147	45	.	.	.
cord-264884-ydkigome	148	1	As	as	IN
cord-264884-ydkigome	148	2	discussed	discuss	VBN
cord-264884-ydkigome	148	3	below	below	IN
cord-264884-ydkigome	148	4	regarding	regard	VBG
cord-264884-ydkigome	148	5	double	double	RB
cord-264884-ydkigome	148	6	-	-	HYPH
cord-264884-ydkigome	148	7	stranded	stranded	JJ
cord-264884-ydkigome	148	8	(	(	-LRB-
cord-264884-ydkigome	148	9	ds)DNA	ds)dna	NN
cord-264884-ydkigome	148	10	viruses	virus	NNS
cord-264884-ydkigome	148	11	of	of	IN
cord-264884-ydkigome	148	12	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	148	13	,	,	,
cord-264884-ydkigome	148	14	they	-PRON-	PRP
cord-264884-ydkigome	148	15	have	have	VBP
cord-264884-ydkigome	148	16	all	all	PDT
cord-264884-ydkigome	148	17	the	the	DT
cord-264884-ydkigome	148	18	above	above	JJ
cord-264884-ydkigome	148	19	characteristics	characteristic	NNS
cord-264884-ydkigome	148	20	.	.	.
cord-264884-ydkigome	149	1	Such	such	JJ
cord-264884-ydkigome	149	2	viruses	virus	NNS
cord-264884-ydkigome	149	3	may	may	MD
cord-264884-ydkigome	149	4	represent	represent	VB
cord-264884-ydkigome	149	5	the	the	DT
cord-264884-ydkigome	149	6	big	big	JJ
cord-264884-ydkigome	149	7	bang	bang	NN
cord-264884-ydkigome	149	8	of	of	IN
cord-264884-ydkigome	149	9	biological	biological	JJ
cord-264884-ydkigome	149	10	novelty	novelty	NN
cord-264884-ydkigome	149	11	.	.	.
cord-264884-ydkigome	150	1	With	with	IN
cord-264884-ydkigome	150	2	their	-PRON-	PRP$
cord-264884-ydkigome	150	3	unmatched	unmatched	JJ
cord-264884-ydkigome	150	4	capacity	capacity	NN
cord-264884-ydkigome	150	5	to	to	TO
cord-264884-ydkigome	150	6	generate	generate	VB
cord-264884-ydkigome	150	7	diversity	diversity	NN
cord-264884-ydkigome	150	8	they	-PRON-	PRP
cord-264884-ydkigome	150	9	can	can	MD
cord-264884-ydkigome	150	10	function	function	VB
cord-264884-ydkigome	150	11	as	as	IN
cord-264884-ydkigome	150	12	the	the	DT
cord-264884-ydkigome	150	13	mass	mass	NN
cord-264884-ydkigome	150	14	creators	creator	NNS
cord-264884-ydkigome	150	15	of	of	IN
cord-264884-ydkigome	150	16	biological	biological	JJ
cord-264884-ydkigome	150	17	novelty	novelty	NN
cord-264884-ydkigome	150	18	as	as	RB
cord-264884-ydkigome	150	19	well	well	RB
cord-264884-ydkigome	150	20	as	as	IN
cord-264884-ydkigome	150	21	destroyers	destroyer	NNS
cord-264884-ydkigome	150	22	of	of	IN
cord-264884-ydkigome	150	23	most	most	JJS
cord-264884-ydkigome	150	24	species	specie	NNS
cord-264884-ydkigome	150	25	.	.	.
cord-264884-ydkigome	151	1	Surely	surely	RB
cord-264884-ydkigome	151	2	,	,	,
cord-264884-ydkigome	151	3	such	such	JJ
cord-264884-ydkigome	151	4	capacity	capacity	NN
cord-264884-ydkigome	151	5	must	must	MD
cord-264884-ydkigome	151	6	have	have	VB
cord-264884-ydkigome	151	7	had	have	VBN
cord-264884-ydkigome	151	8	big	big	JJ
cord-264884-ydkigome	151	9	infl	infl	NN
cord-264884-ydkigome	151	10	uences	uence	NNS
cord-264884-ydkigome	151	11	on	on	IN
cord-264884-ydkigome	151	12	the	the	DT
cord-264884-ydkigome	151	13	evolution	evolution	NN
cord-264884-ydkigome	151	14	of	of	IN
cord-264884-ydkigome	151	15	life	life	NN
cord-264884-ydkigome	151	16	.	.	.
cord-264884-ydkigome	152	1	Symbiosis	symbiosis	NN
cord-264884-ydkigome	152	2	,	,	,
cord-264884-ydkigome	152	3	simply	simply	RB
cord-264884-ydkigome	152	4	defi	defi	NNP
cord-264884-ydkigome	152	5	ned	ned	NNP
cord-264884-ydkigome	152	6	,	,	,
cord-264884-ydkigome	152	7	is	be	VBZ
cord-264884-ydkigome	152	8	the	the	DT
cord-264884-ydkigome	152	9	stable	stable	JJ
cord-264884-ydkigome	152	10	coexistence	coexistence	NN
cord-264884-ydkigome	152	11	of	of	IN
cord-264884-ydkigome	152	12	two	two	CD
cord-264884-ydkigome	152	13	previously	previously	RB
cord-264884-ydkigome	152	14	separate	separate	JJ
cord-264884-ydkigome	152	15	lineages	lineage	NNS
cord-264884-ydkigome	152	16	of	of	IN
cord-264884-ydkigome	152	17	organisms	organism	NNS
cord-264884-ydkigome	152	18	.	.	.
cord-264884-ydkigome	153	1	There	there	EX
cord-264884-ydkigome	153	2	can	can	MD
cord-264884-ydkigome	153	3	be	be	VB
cord-264884-ydkigome	153	4	little	little	JJ
cord-264884-ydkigome	153	5	doubt	doubt	NN
cord-264884-ydkigome	153	6	that	that	IN
cord-264884-ydkigome	153	7	many	many	JJ
cord-264884-ydkigome	153	8	temperate	temperate	JJ
cord-264884-ydkigome	153	9	phage	phage	NN
cord-264884-ydkigome	153	10	can	can	MD
cord-264884-ydkigome	153	11	stably	stably	RB
cord-264884-ydkigome	153	12	colonize	colonize	VB
cord-264884-ydkigome	153	13	a	a	DT
cord-264884-ydkigome	153	14	bacterial	bacterial	JJ
cord-264884-ydkigome	153	15	cell	cell	NN
cord-264884-ydkigome	153	16	resulting	result	VBG
cord-264884-ydkigome	153	17	in	in	IN
cord-264884-ydkigome	153	18	a	a	DT
cord-264884-ydkigome	153	19	stable	stable	JJ
cord-264884-ydkigome	153	20	descendent	descendent	NN
cord-264884-ydkigome	153	21	from	from	IN
cord-264884-ydkigome	153	22	two	two	CD
cord-264884-ydkigome	153	23	lineages	lineage	NNS
cord-264884-ydkigome	153	24	.	.	.
cord-264884-ydkigome	154	1	This	this	DT
cord-264884-ydkigome	154	2	is	be	VBZ
cord-264884-ydkigome	154	3	clearly	clearly	RB
cord-264884-ydkigome	154	4	symbiotic	symbiotic	JJ
cord-264884-ydkigome	154	5	.	.	.
cord-264884-ydkigome	155	1	Endogenous	endogenous	JJ
cord-264884-ydkigome	155	2	retroviruses	retrovirus	NNS
cord-264884-ydkigome	155	3	can	can	MD
cord-264884-ydkigome	155	4	similarly	similarly	RB
cord-264884-ydkigome	155	5	be	be	VB
cord-264884-ydkigome	155	6	found	find	VBN
cord-264884-ydkigome	155	7	to	to	TO
cord-264884-ydkigome	155	8	persist	persist	VB
cord-264884-ydkigome	155	9	in	in	IN
cord-264884-ydkigome	155	10	vertebrate	vertebrate	JJ
cord-264884-ydkigome	155	11	genomes	genome	NNS
cord-264884-ydkigome	155	12	and	and	CC
cord-264884-ydkigome	155	13	also	also	RB
cord-264884-ydkigome	155	14	appear	appear	VB
cord-264884-ydkigome	155	15	symbiotic	symbiotic	JJ
cord-264884-ydkigome	155	16	.	.	.
cord-264884-ydkigome	156	1	Yet	yet	CC
cord-264884-ydkigome	156	2	studies	study	NNS
cord-264884-ydkigome	156	3	of	of	IN
cord-264884-ydkigome	156	4	symbiosis	symbiosis	NN
cord-264884-ydkigome	156	5	seldom	seldom	RB
cord-264884-ydkigome	156	6	consider	consider	VBP
cord-264884-ydkigome	156	7	a	a	DT
cord-264884-ydkigome	156	8	role	role	NN
cord-264884-ydkigome	156	9	for	for	IN
cord-264884-ydkigome	156	10	virus	virus	NN
cord-264884-ydkigome	156	11	(	(	-LRB-
cord-264884-ydkigome	156	12	Villarreal	Villarreal	NNP
cord-264884-ydkigome	156	13	,	,	,
cord-264884-ydkigome	156	14	2007	2007	CD
cord-264884-ydkigome	156	15	)	)	-RRB-
cord-264884-ydkigome	156	16	.	.	.
cord-264884-ydkigome	157	1	How	how	WRB
cord-264884-ydkigome	157	2	important	important	JJ
cord-264884-ydkigome	157	3	are	be	VBP
cord-264884-ydkigome	157	4	viruses	virus	NNS
cord-264884-ydkigome	157	5	in	in	IN
cord-264884-ydkigome	157	6	general	general	JJ
cord-264884-ydkigome	157	7	to	to	IN
cord-264884-ydkigome	157	8	evolutionary	evolutionary	JJ
cord-264884-ydkigome	157	9	biology	biology	NN
cord-264884-ydkigome	157	10	?	?	.
cord-264884-ydkigome	158	1	The	the	DT
cord-264884-ydkigome	158	2	core	core	NN
cord-264884-ydkigome	158	3	concepts	concept	NNS
cord-264884-ydkigome	158	4	of	of	IN
cord-264884-ydkigome	158	5	evolutionary	evolutionary	JJ
cord-264884-ydkigome	158	6	biology	biology	NN
cord-264884-ydkigome	158	7	were	be	VBD
cord-264884-ydkigome	158	8	developed	develop	VBN
cord-264884-ydkigome	158	9	well	well	RB
cord-264884-ydkigome	158	10	before	before	IN
cord-264884-ydkigome	158	11	we	-PRON-	PRP
cord-264884-ydkigome	158	12	had	have	VBD
cord-264884-ydkigome	158	13	a	a	DT
cord-264884-ydkigome	158	14	modern	modern	JJ
cord-264884-ydkigome	158	15	understanding	understanding	NN
cord-264884-ydkigome	158	16	and	and	CC
cord-264884-ydkigome	158	17	defi	defi	NNP
cord-264884-ydkigome	158	18	nition	nition	NN
cord-264884-ydkigome	158	19	of	of	IN
cord-264884-ydkigome	158	20	viruses	virus	NNS
cord-264884-ydkigome	158	21	(	(	-LRB-
cord-264884-ydkigome	158	22	Luria	Luria	NNP
cord-264884-ydkigome	158	23	,	,	,
cord-264884-ydkigome	158	24	1950	1950	CD
cord-264884-ydkigome	158	25	)	)	-RRB-
cord-264884-ydkigome	158	26	.	.	.
cord-264884-ydkigome	159	1	After	after	RB
cord-264884-ydkigome	159	2	all	all	RB
cord-264884-ydkigome	159	3	,	,	,
cord-264884-ydkigome	159	4	the	the	DT
cord-264884-ydkigome	159	5	basic	basic	JJ
cord-264884-ydkigome	159	6	lysogenic	lysogenic	JJ
cord-264884-ydkigome	159	7	model	model	NN
cord-264884-ydkigome	159	8	of	of	IN
cord-264884-ydkigome	159	9	phage	phage	NN
cord-264884-ydkigome	159	10	integration	integration	NN
cord-264884-ydkigome	159	11	was	be	VBD
cord-264884-ydkigome	159	12	only	only	RB
cord-264884-ydkigome	159	13	clarifi	clarifi	FW
cord-264884-ydkigome	159	14	ed	ed	NN
cord-264884-ydkigome	159	15	in	in	IN
cord-264884-ydkigome	159	16	1962	1962	CD
cord-264884-ydkigome	159	17	when	when	WRB
cord-264884-ydkigome	159	18	developed	develop	VBN
cord-264884-ydkigome	159	19	by	by	IN
cord-264884-ydkigome	159	20	Campbell	Campbell	NNP
cord-264884-ydkigome	159	21	(	(	-LRB-
cord-264884-ydkigome	159	22	see	see	VB
cord-264884-ydkigome	159	23	Campbell	Campbell	NNP
cord-264884-ydkigome	159	24	,	,	,
cord-264884-ydkigome	159	25	2007	2007	CD
cord-264884-ydkigome	159	26	)	)	-RRB-
cord-264884-ydkigome	159	27	.	.	.
cord-264884-ydkigome	160	1	That	that	DT
cord-264884-ydkigome	160	2	cryptic	cryptic	JJ
cord-264884-ydkigome	160	3	and	and	CC
cord-264884-ydkigome	160	4	defective	defective	JJ
cord-264884-ydkigome	160	5	phage	phage	NN
cord-264884-ydkigome	160	6	are	be	VBP
cord-264884-ydkigome	160	7	ubiquitous	ubiquitous	JJ
cord-264884-ydkigome	160	8	in	in	IN
cord-264884-ydkigome	160	9	the	the	DT
cord-264884-ydkigome	160	10	genomes	genome	NNS
cord-264884-ydkigome	160	11	of	of	IN
cord-264884-ydkigome	160	12	all	all	DT
cord-264884-ydkigome	160	13	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	160	14	is	be	VBZ
cord-264884-ydkigome	160	15	generally	generally	RB
cord-264884-ydkigome	160	16	considered	consider	VBN
cord-264884-ydkigome	160	17	uninteresting	uninteresting	JJ
cord-264884-ydkigome	160	18	by	by	IN
cord-264884-ydkigome	160	19	many	many	JJ
cord-264884-ydkigome	160	20	in	in	IN
cord-264884-ydkigome	160	21	the	the	DT
cord-264884-ydkigome	160	22	fi	fi	NNP
cord-264884-ydkigome	160	23	eld	eld	NN
cord-264884-ydkigome	160	24	of	of	IN
cord-264884-ydkigome	160	25	evolutionary	evolutionary	JJ
cord-264884-ydkigome	160	26	biology	biology	NN
cord-264884-ydkigome	160	27	.	.	.
cord-264884-ydkigome	161	1	I	-PRON-	PRP
cord-264884-ydkigome	161	2	suggest	suggest	VBP
cord-264884-ydkigome	161	3	that	that	IN
cord-264884-ydkigome	161	4	the	the	DT
cord-264884-ydkigome	161	5	seemingly	seemingly	RB
cord-264884-ydkigome	161	6	applicable	applicable	JJ
cord-264884-ydkigome	161	7	concepts	concept	NNS
cord-264884-ydkigome	161	8	of	of	IN
cord-264884-ydkigome	161	9	selfi	selfi	NNP
cord-264884-ydkigome	161	10	sh	sh	NNP
cord-264884-ydkigome	161	11	DNA	DNA	NNP
cord-264884-ydkigome	161	12	effectively	effectively	RB
cord-264884-ydkigome	161	13	derailed	derail	VBD
cord-264884-ydkigome	161	14	any	any	DT
cord-264884-ydkigome	161	15	thinking	thinking	NN
cord-264884-ydkigome	161	16	that	that	IN
cord-264884-ydkigome	161	17	persisting	persist	VBG
cord-264884-ydkigome	161	18	genetic	genetic	JJ
cord-264884-ydkigome	161	19	parasites	parasite	NNS
cord-264884-ydkigome	161	20	might	may	MD
cord-264884-ydkigome	161	21	have	have	VB
cord-264884-ydkigome	161	22	a	a	DT
cord-264884-ydkigome	161	23	more	more	RBR
cord-264884-ydkigome	161	24	germinal	germinal	JJ
cord-264884-ydkigome	161	25	role	role	NN
cord-264884-ydkigome	161	26	in	in	IN
cord-264884-ydkigome	161	27	the	the	DT
cord-264884-ydkigome	161	28	evolution	evolution	NN
cord-264884-ydkigome	161	29	of	of	IN
cord-264884-ydkigome	161	30	life	life	NN
cord-264884-ydkigome	161	31	(	(	-LRB-
cord-264884-ydkigome	161	32	Doolittle	Doolittle	NNP
cord-264884-ydkigome	161	33	and	and	CC
cord-264884-ydkigome	161	34	Sapienza	Sapienza	NNP
cord-264884-ydkigome	161	35	,	,	,
cord-264884-ydkigome	161	36	1980	1980	CD
cord-264884-ydkigome	161	37	;	;	:
cord-264884-ydkigome	161	38	Orgel	Orgel	NNP
cord-264884-ydkigome	161	39	and	and	CC
cord-264884-ydkigome	161	40	Crick	Crick	NNP
cord-264884-ydkigome	161	41	,	,	,
cord-264884-ydkigome	161	42	1980	1980	CD
cord-264884-ydkigome	161	43	)	)	-RRB-
cord-264884-ydkigome	161	44	.	.	.
cord-264884-ydkigome	162	1	Yet	yet	CC
cord-264884-ydkigome	162	2	as	as	IN
cord-264884-ydkigome	162	3	outlined	outline	VBN
cord-264884-ydkigome	162	4	above	above	RB
cord-264884-ydkigome	162	5	,	,	,
cord-264884-ydkigome	162	6	virus	virus	NN
cord-264884-ydkigome	162	7	footprints	footprint	NNS
cord-264884-ydkigome	162	8	in	in	IN
cord-264884-ydkigome	162	9	major	major	JJ
cord-264884-ydkigome	162	10	evolutionary	evolutionary	JJ
cord-264884-ydkigome	162	11	transitions	transition	NNS
cord-264884-ydkigome	162	12	are	be	VBP
cord-264884-ydkigome	162	13	clear	clear	JJ
cord-264884-ydkigome	162	14	and	and	CC
cord-264884-ydkigome	162	15	a	a	DT
cord-264884-ydkigome	162	16	direct	direct	JJ
cord-264884-ydkigome	162	17	role	role	NN
cord-264884-ydkigome	162	18	in	in	IN
cord-264884-ydkigome	162	19	such	such	JJ
cord-264884-ydkigome	162	20	events	event	NNS
cord-264884-ydkigome	162	21	now	now	RB
cord-264884-ydkigome	162	22	seems	seem	VBZ
cord-264884-ydkigome	162	23	much	much	RB
cord-264884-ydkigome	162	24	more	more	RBR
cord-264884-ydkigome	162	25	plausible	plausible	JJ
cord-264884-ydkigome	162	26	.	.	.
cord-264884-ydkigome	163	1	We	-PRON-	PRP
cord-264884-ydkigome	163	2	therefore	therefore	RB
cord-264884-ydkigome	163	3	must	must	MD
cord-264884-ydkigome	163	4	seek	seek	VB
cord-264884-ydkigome	163	5	to	to	IN
cord-264884-ydkigome	163	6	defi	defi	NNP
cord-264884-ydkigome	163	7	ning	ning	NNP
cord-264884-ydkigome	163	8	the	the	DT
cord-264884-ydkigome	163	9	nature	nature	NN
cord-264884-ydkigome	163	10	of	of	IN
cord-264884-ydkigome	163	11	the	the	DT
cord-264884-ydkigome	163	12	virosphere	virosphere	NN
cord-264884-ydkigome	163	13	and	and	CC
cord-264884-ydkigome	163	14	how	how	WRB
cord-264884-ydkigome	163	15	its	-PRON-	PRP$
cord-264884-ydkigome	163	16	evolution	evolution	NN
cord-264884-ydkigome	163	17	relates	relate	VBZ
cord-264884-ydkigome	163	18	to	to	IN
cord-264884-ydkigome	163	19	the	the	DT
cord-264884-ydkigome	163	20	tree	tree	NN
cord-264884-ydkigome	163	21	of	of	IN
cord-264884-ydkigome	163	22	life	life	NN
cord-264884-ydkigome	163	23	.	.	.
cord-264884-ydkigome	164	1	This	this	DT
cord-264884-ydkigome	164	2	book	book	NN
cord-264884-ydkigome	164	3	represents	represent	VBZ
cord-264884-ydkigome	164	4	the	the	DT
cord-264884-ydkigome	164	5	fi	fi	NNP
cord-264884-ydkigome	164	6	rst	rst	NN
cord-264884-ydkigome	164	7	integration	integration	NN
cord-264884-ydkigome	164	8	of	of	IN
cord-264884-ydkigome	164	9	the	the	DT
cord-264884-ydkigome	164	10	entire	entire	JJ
cord-264884-ydkigome	164	11	fi	fi	NN
cord-264884-ydkigome	164	12	eld	eld	NN
cord-264884-ydkigome	164	13	of	of	IN
cord-264884-ydkigome	164	14	virus	virus	NN
cord-264884-ydkigome	164	15	evolution	evolution	NN
cord-264884-ydkigome	164	16	,	,	,
cord-264884-ydkigome	164	17	including	include	VBG
cord-264884-ydkigome	164	18	both	both	DT
cord-264884-ydkigome	164	19	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	164	20	and	and	CC
cord-264884-ydkigome	164	21	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	164	22	life	life	NN
cord-264884-ydkigome	164	23	forms	form	NNS
cord-264884-ydkigome	164	24	.	.	.
cord-264884-ydkigome	165	1	However	however	RB
cord-264884-ydkigome	165	2	,	,	,
cord-264884-ydkigome	165	3	because	because	IN
cord-264884-ydkigome	165	4	our	-PRON-	PRP$
cord-264884-ydkigome	165	5	understanding	understanding	NN
cord-264884-ydkigome	165	6	of	of	IN
cord-264884-ydkigome	165	7	virushost	virushost	NN
cord-264884-ydkigome	165	8	relationships	relationship	NNS
cord-264884-ydkigome	165	9	remains	remain	VBZ
cord-264884-ydkigome	165	10	uneven	uneven	JJ
cord-264884-ydkigome	165	11	,	,	,
cord-264884-ydkigome	165	12	the	the	DT
cord-264884-ydkigome	165	13	chapters	chapter	NNS
cord-264884-ydkigome	165	14	necessarily	necessarily	RB
cord-264884-ydkigome	165	15	focus	focus	VBP
cord-264884-ydkigome	165	16	on	on	IN
cord-264884-ydkigome	165	17	well	well	RB
cord-264884-ydkigome	165	18	-	-	HYPH
cord-264884-ydkigome	165	19	studied	study	VBN
cord-264884-ydkigome	165	20	models	model	NNS
cord-264884-ydkigome	165	21	(	(	-LRB-
cord-264884-ydkigome	165	22	exemplars	exemplar	NNS
cord-264884-ydkigome	165	23	)	)	-RRB-
cord-264884-ydkigome	165	24	.	.	.
cord-264884-ydkigome	166	1	These	these	DT
cord-264884-ydkigome	166	2	exemplars	exemplar	NNS
cord-264884-ydkigome	166	3	also	also	RB
cord-264884-ydkigome	166	4	tend	tend	VBP
cord-264884-ydkigome	166	5	to	to	TO
cord-264884-ydkigome	166	6	refl	refl	VB
cord-264884-ydkigome	166	7	ect	ect	NNP
cord-264884-ydkigome	166	8	a	a	DT
cord-264884-ydkigome	166	9	historic	historic	JJ
cord-264884-ydkigome	166	10	disease	disease	NN
cord-264884-ydkigome	166	11	focus	focus	NN
cord-264884-ydkigome	166	12	(	(	-LRB-
cord-264884-ydkigome	166	13	i.e.	i.e.	FW
cord-264884-ydkigome	166	14	,	,	,
cord-264884-ydkigome	166	15	E.	E.	NNP
cord-264884-ydkigome	166	16	coli	coli	NNS
cord-264884-ydkigome	166	17	,	,	,
cord-264884-ydkigome	166	18	fl	fl	NNP
cord-264884-ydkigome	166	19	owering	owering	NN
cord-264884-ydkigome	166	20	plants	plant	NNS
cord-264884-ydkigome	166	21	,	,	,
cord-264884-ydkigome	166	22	mouse	mouse	NN
cord-264884-ydkigome	166	23	,	,	,
cord-264884-ydkigome	166	24	humans	human	NNS
cord-264884-ydkigome	166	25	)	)	-RRB-
cord-264884-ydkigome	166	26	.	.	.
cord-264884-ydkigome	167	1	It	-PRON-	PRP
cord-264884-ydkigome	167	2	is	be	VBZ
cord-264884-ydkigome	167	3	unfortunate	unfortunate	JJ
cord-264884-ydkigome	167	4	that	that	IN
cord-264884-ydkigome	167	5	the	the	DT
cord-264884-ydkigome	167	6	silent	silent	JJ
cord-264884-ydkigome	167	7	species	specie	NNS
cord-264884-ydkigome	167	8	-	-	HYPH
cord-264884-ydkigome	167	9	specifi	specifi	VBN
cord-264884-ydkigome	168	1	c	c	LS
cord-264884-ydkigome	168	2	viruses	virus	NNS
cord-264884-ydkigome	168	3	that	that	WDT
cord-264884-ydkigome	168	4	tend	tend	VBP
cord-264884-ydkigome	168	5	to	to	TO
cord-264884-ydkigome	168	6	exist	exist	VB
cord-264884-ydkigome	168	7	in	in	IN
cord-264884-ydkigome	168	8	stable	stable	JJ
cord-264884-ydkigome	168	9	states	state	NNS
cord-264884-ydkigome	168	10	with	with	IN
cord-264884-ydkigome	168	11	long	long	JJ
cord-264884-ydkigome	168	12	evolutionary	evolutionary	JJ
cord-264884-ydkigome	168	13	histories	history	NNS
cord-264884-ydkigome	168	14	seldom	seldom	RB
cord-264884-ydkigome	168	15	provide	provide	VBP
cord-264884-ydkigome	168	16	our	-PRON-	PRP$
cord-264884-ydkigome	168	17	examplars	examplar	NNS
cord-264884-ydkigome	168	18	.	.	.
cord-264884-ydkigome	169	1	We	-PRON-	PRP
cord-264884-ydkigome	169	2	understand	understand	VBP
cord-264884-ydkigome	169	3	these	these	DT
cord-264884-ydkigome	169	4	infections	infection	NNS
cord-264884-ydkigome	169	5	poorly	poorly	RB
cord-264884-ydkigome	169	6	and	and	CC
cord-264884-ydkigome	169	7	lack	lack	VBP
cord-264884-ydkigome	169	8	basic	basic	JJ
cord-264884-ydkigome	169	9	defi	defi	NN
cord-264884-ydkigome	169	10	nitions	nition	NNS
cord-264884-ydkigome	169	11	concerning	concern	VBG
cord-264884-ydkigome	169	12	fi	fi	IN
cord-264884-ydkigome	169	13	tness	tness	NN
cord-264884-ydkigome	169	14	or	or	CC
cord-264884-ydkigome	169	15	selective	selective	JJ
cord-264884-ydkigome	169	16	advantages	advantage	NNS
cord-264884-ydkigome	169	17	.	.	.
cord-264884-ydkigome	170	1	Only	only	RB
cord-264884-ydkigome	170	2	metagenomics	metagenomic	NNS
cord-264884-ydkigome	170	3	tools	tool	NNS
cord-264884-ydkigome	170	4	now	now	RB
cord-264884-ydkigome	170	5	seem	seem	VBP
cord-264884-ydkigome	170	6	able	able	JJ
cord-264884-ydkigome	170	7	to	to	TO
cord-264884-ydkigome	170	8	inform	inform	VB
cord-264884-ydkigome	170	9	us	-PRON-	PRP
cord-264884-ydkigome	170	10	of	of	IN
cord-264884-ydkigome	170	11	their	-PRON-	PRP$
cord-264884-ydkigome	170	12	presence	presence	NN
cord-264884-ydkigome	170	13	,	,	,
cord-264884-ydkigome	170	14	but	but	CC
cord-264884-ydkigome	170	15	not	not	RB
cord-264884-ydkigome	170	16	their	-PRON-	PRP$
cord-264884-ydkigome	170	17	biology	biology	NN
cord-264884-ydkigome	170	18	.	.	.
cord-264884-ydkigome	171	1	Self	self	NN
cord-264884-ydkigome	171	2	-	-	HYPH
cord-264884-ydkigome	171	3	organization	organization	NN
cord-264884-ydkigome	171	4	and	and	CC
cord-264884-ydkigome	171	5	the	the	DT
cord-264884-ydkigome	171	6	evolution	evolution	NN
cord-264884-ydkigome	171	7	of	of	IN
cord-264884-ydkigome	171	8	RNA	RNA	NNP
cord-264884-ydkigome	171	9	molecules	molecule	NNS
cord-264884-ydkigome	171	10	as	as	IN
cord-264884-ydkigome	171	11	an	an	DT
cord-264884-ydkigome	171	12	origin	origin	NN
cord-264884-ydkigome	171	13	of	of	IN
cord-264884-ydkigome	171	14	biological	biological	JJ
cord-264884-ydkigome	171	15	information	information	NN
cord-264884-ydkigome	171	16	are	be	VBP
cord-264884-ydkigome	171	17	discussed	discuss	VBN
cord-264884-ydkigome	171	18	in	in	IN
cord-264884-ydkigome	171	19	Chapter	chapter	NN
cord-264884-ydkigome	171	20	1	1	CD
cord-264884-ydkigome	171	21	.	.	.
cord-264884-ydkigome	172	1	Autocatalytic	autocatalytic	JJ
cord-264884-ydkigome	172	2	chemical	chemical	NN
cord-264884-ydkigome	172	3	reactions	reaction	NNS
cord-264884-ydkigome	172	4	,	,	,
cord-264884-ydkigome	172	5	such	such	JJ
cord-264884-ydkigome	172	6	as	as	IN
cord-264884-ydkigome	172	7	replication	replication	NN
cord-264884-ydkigome	172	8	of	of	IN
cord-264884-ydkigome	172	9	RNA	RNA	NNP
cord-264884-ydkigome	172	10	,	,	,
cord-264884-ydkigome	172	11	presents	present	VBZ
cord-264884-ydkigome	172	12	issues	issue	NNS
cord-264884-ydkigome	172	13	such	such	JJ
cord-264884-ydkigome	172	14	as	as	IN
cord-264884-ydkigome	172	15	how	how	WRB
cord-264884-ydkigome	172	16	to	to	TO
cord-264884-ydkigome	172	17	optimize	optimize	VB
cord-264884-ydkigome	172	18	a	a	DT
cord-264884-ydkigome	172	19	rugged	rugged	JJ
cord-264884-ydkigome	172	20	fi	fi	IN
cord-264884-ydkigome	172	21	tness	tness	NN
cord-264884-ydkigome	172	22	landscape	landscape	NN
cord-264884-ydkigome	172	23	yet	yet	RB
cord-264884-ydkigome	172	24	allow	allow	VBP
cord-264884-ydkigome	172	25	the	the	DT
cord-264884-ydkigome	172	26	study	study	NN
cord-264884-ydkigome	172	27	of	of	IN
cord-264884-ydkigome	172	28	evolution	evolution	NN
cord-264884-ydkigome	172	29	in	in	IN
cord-264884-ydkigome	172	30	vitro	vitro	FW
cord-264884-ydkigome	172	31	with	with	IN
cord-264884-ydkigome	172	32	RNA	RNA	NNP
cord-264884-ydkigome	172	33	.	.	.
cord-264884-ydkigome	173	1	RNA	RNA	NNP
cord-264884-ydkigome	173	2	in	in	IN
cord-264884-ydkigome	173	3	vitro	vitro	FW
cord-264884-ydkigome	173	4	reduces	reduce	VBZ
cord-264884-ydkigome	173	5	genotype	genotype	NN
cord-264884-ydkigome	173	6	-	-	HYPH
cord-264884-ydkigome	173	7	phenotype	phenotype	NN
cord-264884-ydkigome	173	8	issues	issue	NNS
cord-264884-ydkigome	173	9	to	to	IN
cord-264884-ydkigome	173	10	RNA	RNA	NNP
cord-264884-ydkigome	173	11	secondary	secondary	JJ
cord-264884-ydkigome	173	12	structure	structure	NN
cord-264884-ydkigome	173	13	and	and	CC
cord-264884-ydkigome	173	14	minimal	minimal	JJ
cord-264884-ydkigome	173	15	free	free	JJ
cord-264884-ydkigome	173	16	energy	energy	NN
cord-264884-ydkigome	173	17	states	state	NNS
cord-264884-ydkigome	173	18	.	.	.
cord-264884-ydkigome	174	1	This	this	DT
cord-264884-ydkigome	174	2	allows	allow	VBZ
cord-264884-ydkigome	174	3	both	both	CC
cord-264884-ydkigome	174	4	continuity	continuity	NN
cord-264884-ydkigome	174	5	and	and	CC
cord-264884-ydkigome	174	6	discontinuity	discontinuity	NN
cord-264884-ydkigome	174	7	to	to	TO
cord-264884-ydkigome	174	8	be	be	VB
cord-264884-ydkigome	174	9	measured	measure	VBN
cord-264884-ydkigome	174	10	.	.	.
cord-264884-ydkigome	175	1	These	these	DT
cord-264884-ydkigome	175	2	same	same	JJ
cord-264884-ydkigome	175	3	issues	issue	NNS
cord-264884-ydkigome	175	4	are	be	VBP
cord-264884-ydkigome	175	5	crucial	crucial	JJ
cord-264884-ydkigome	175	6	for	for	IN
cord-264884-ydkigome	175	7	the	the	DT
cord-264884-ydkigome	175	8	study	study	NN
cord-264884-ydkigome	175	9	of	of	IN
cord-264884-ydkigome	175	10	RNA	RNA	NNP
cord-264884-ydkigome	175	11	viruses	virus	NNS
cord-264884-ydkigome	175	12	,	,	,
cord-264884-ydkigome	175	13	whose	whose	WP$
cord-264884-ydkigome	175	14	sites	site	NNS
cord-264884-ydkigome	175	15	of	of	IN
cord-264884-ydkigome	175	16	secondary	secondary	JJ
cord-264884-ydkigome	175	17	structure	structure	NN
cord-264884-ydkigome	175	18	often	often	RB
cord-264884-ydkigome	175	19	defi	defi	VBP
cord-264884-ydkigome	175	20	ne	ne	NNP
cord-264884-ydkigome	175	21	replicator	replicator	NN
cord-264884-ydkigome	175	22	identity	identity	NN
cord-264884-ydkigome	175	23	.	.	.
cord-264884-ydkigome	176	1	These	these	DT
cord-264884-ydkigome	176	2	models	model	NNS
cord-264884-ydkigome	176	3	currently	currently	RB
cord-264884-ydkigome	176	4	offer	offer	VBP
cord-264884-ydkigome	176	5	the	the	DT
cord-264884-ydkigome	176	6	best	good	JJS
cord-264884-ydkigome	176	7	system	system	NN
cord-264884-ydkigome	176	8	to	to	TO
cord-264884-ydkigome	176	9	evaluate	evaluate	VB
cord-264884-ydkigome	176	10	an	an	DT
cord-264884-ydkigome	176	11	early	early	JJ
cord-264884-ydkigome	176	12	and	and	CC
cord-264884-ydkigome	176	13	simple	simple	JJ
cord-264884-ydkigome	176	14	biological	biological	JJ
cord-264884-ydkigome	176	15	world	world	NN
cord-264884-ydkigome	176	16	for	for	IN
cord-264884-ydkigome	176	17	evolutionary	evolutionary	JJ
cord-264884-ydkigome	176	18	principles	principle	NNS
cord-264884-ydkigome	176	19	(	(	-LRB-
cord-264884-ydkigome	176	20	see	see	VB
cord-264884-ydkigome	176	21	Chapter	chapter	NN
cord-264884-ydkigome	176	22	3	3	CD
cord-264884-ydkigome	176	23	)	)	-RRB-
cord-264884-ydkigome	176	24	.	.	.
cord-264884-ydkigome	177	1	Viruses	virus	NNS
cord-264884-ydkigome	177	2	and	and	CC
cord-264884-ydkigome	177	3	viroids	viroid	NNS
cord-264884-ydkigome	177	4	with	with	IN
cord-264884-ydkigome	177	5	their	-PRON-	PRP$
cord-264884-ydkigome	177	6	RNA	RNA	NNP
cord-264884-ydkigome	177	7	genomes	genome	NNS
cord-264884-ydkigome	177	8	may	may	MD
cord-264884-ydkigome	177	9	be	be	VB
cord-264884-ydkigome	177	10	the	the	DT
cord-264884-ydkigome	177	11	only	only	JJ
cord-264884-ydkigome	177	12	extant	extant	JJ
cord-264884-ydkigome	177	13	survivors	survivor	NNS
cord-264884-ydkigome	177	14	of	of	IN
cord-264884-ydkigome	177	15	this	this	DT
cord-264884-ydkigome	177	16	pre	pre	JJ
cord-264884-ydkigome	177	17	-	-	JJ
cord-264884-ydkigome	177	18	DNA	dna	JJ
cord-264884-ydkigome	177	19	world	world	NN
cord-264884-ydkigome	177	20	.	.	.
cord-264884-ydkigome	178	1	Since	since	IN
cord-264884-ydkigome	178	2	it	-PRON-	PRP
cord-264884-ydkigome	178	3	was	be	VBD
cord-264884-ydkigome	178	4	the	the	DT
cord-264884-ydkigome	178	5	consideration	consideration	NN
cord-264884-ydkigome	178	6	of	of	IN
cord-264884-ydkigome	178	7	error	error	NN
cord-264884-ydkigome	178	8	-	-	HYPH
cord-264884-ydkigome	178	9	prone	prone	JJ
cord-264884-ydkigome	178	10	replication	replication	NN
cord-264884-ydkigome	178	11	that	that	WDT
cord-264884-ydkigome	178	12	led	lead	VBD
cord-264884-ydkigome	178	13	to	to	IN
cord-264884-ydkigome	178	14	the	the	DT
cord-264884-ydkigome	178	15	development	development	NN
cord-264884-ydkigome	178	16	of	of	IN
cord-264884-ydkigome	178	17	the	the	DT
cord-264884-ydkigome	178	18	concept	concept	NN
cord-264884-ydkigome	178	19	of	of	IN
cord-264884-ydkigome	178	20	quasispecies	quasispecie	NNS
cord-264884-ydkigome	178	21	(	(	-LRB-
cord-264884-ydkigome	178	22	see	see	VB
cord-264884-ydkigome	178	23	Chapter	chapter	NN
cord-264884-ydkigome	178	24	2	2	CD
cord-264884-ydkigome	178	25	)	)	-RRB-
cord-264884-ydkigome	178	26	,	,	,
cord-264884-ydkigome	178	27	such	such	JJ
cord-264884-ydkigome	178	28	models	model	NNS
cord-264884-ydkigome	178	29	have	have	VBP
cord-264884-ydkigome	178	30	provided	provide	VBN
cord-264884-ydkigome	178	31	a	a	DT
cord-264884-ydkigome	178	32	conceptual	conceptual	JJ
cord-264884-ydkigome	178	33	foundation	foundation	NN
cord-264884-ydkigome	178	34	which	which	WDT
cord-264884-ydkigome	178	35	led	lead	VBD
cord-264884-ydkigome	178	36	to	to	IN
cord-264884-ydkigome	178	37	several	several	JJ
cord-264884-ydkigome	178	38	basic	basic	JJ
cord-264884-ydkigome	178	39	concepts	concept	NNS
cord-264884-ydkigome	178	40	.	.	.
cord-264884-ydkigome	179	1	Chapter	chapter	NN
cord-264884-ydkigome	179	2	4	4	CD
cord-264884-ydkigome	179	3	discussed	discuss	VBD
cord-264884-ydkigome	179	4	the	the	DT
cord-264884-ydkigome	179	5	foundations	foundation	NNS
cord-264884-ydkigome	179	6	and	and	CC
cord-264884-ydkigome	179	7	various	various	JJ
cord-264884-ydkigome	179	8	aspects	aspect	NNS
cord-264884-ydkigome	179	9	of	of	IN
cord-264884-ydkigome	179	10	quasispecies	quasispecie	NNS
cord-264884-ydkigome	179	11	theory	theory	NN
cord-264884-ydkigome	179	12	.	.	.
cord-264884-ydkigome	180	1	Viruses	virus	NNS
cord-264884-ydkigome	180	2	appear	appear	VBP
cord-264884-ydkigome	180	3	to	to	TO
cord-264884-ydkigome	180	4	operate	operate	VB
cord-264884-ydkigome	180	5	close	close	RB
cord-264884-ydkigome	180	6	to	to	IN
cord-264884-ydkigome	180	7	the	the	DT
cord-264884-ydkigome	180	8	error	error	NN
cord-264884-ydkigome	180	9	threshold	threshold	NN
cord-264884-ydkigome	180	10	,	,	,
cord-264884-ydkigome	180	11	thus	thus	RB
cord-264884-ydkigome	180	12	allowing	allow	VBG
cord-264884-ydkigome	180	13	maximum	maximum	JJ
cord-264884-ydkigome	180	14	evolutionary	evolutionary	JJ
cord-264884-ydkigome	180	15	exploration	exploration	NN
cord-264884-ydkigome	180	16	(	(	-LRB-
cord-264884-ydkigome	180	17	Biebricher	Biebricher	NNP
cord-264884-ydkigome	180	18	and	and	CC
cord-264884-ydkigome	180	19	Eigen	Eigen	NNP
cord-264884-ydkigome	180	20	,	,	,
cord-264884-ydkigome	180	21	2006	2006	CD
cord-264884-ydkigome	180	22	)	)	-RRB-
cord-264884-ydkigome	180	23	.	.	.
cord-264884-ydkigome	181	1	However	however	RB
cord-264884-ydkigome	181	2	,	,	,
cord-264884-ydkigome	181	3	as	as	IN
cord-264884-ydkigome	181	4	presented	present	VBN
cord-264884-ydkigome	181	5	below	below	RB
cord-264884-ydkigome	181	6	,	,	,
cord-264884-ydkigome	181	7	the	the	DT
cord-264884-ydkigome	181	8	loss	loss	NN
cord-264884-ydkigome	181	9	of	of	IN
cord-264884-ydkigome	181	10	the	the	DT
cord-264884-ydkigome	181	11	"	"	``
cord-264884-ydkigome	181	12	fi	fi	NNP
cord-264884-ydkigome	181	13	ttest	tt	JJS
cord-264884-ydkigome	181	14	"	"	''
cord-264884-ydkigome	181	15	type	type	NN
cord-264884-ydkigome	181	16	concept	concept	NN
cord-264884-ydkigome	181	17	has	have	VBZ
cord-264884-ydkigome	181	18	also	also	RB
cord-264884-ydkigome	181	19	led	lead	VBN
cord-264884-ydkigome	181	20	to	to	TO
cord-264884-ydkigome	181	21	clear	clear	VB
cord-264884-ydkigome	181	22	experimental	experimental	JJ
cord-264884-ydkigome	181	23	evaluations	evaluation	NNS
cord-264884-ydkigome	181	24	of	of	IN
cord-264884-ydkigome	181	25	consortia	consortia	NN
cord-264884-ydkigome	181	26	-	-	HYPH
cord-264884-ydkigome	181	27	based	base	VBN
cord-264884-ydkigome	181	28	evolutionary	evolutionary	JJ
cord-264884-ydkigome	181	29	behaviors	behavior	NNS
cord-264884-ydkigome	181	30	.	.	.
cord-264884-ydkigome	182	1	Such	such	JJ
cord-264884-ydkigome	182	2	behaviors	behavior	NNS
cord-264884-ydkigome	182	3	were	be	VBD
cord-264884-ydkigome	182	4	not	not	RB
cord-264884-ydkigome	182	5	predicted	predict	VBN
cord-264884-ydkigome	182	6	by	by	IN
cord-264884-ydkigome	182	7	classical	classical	JJ
cord-264884-ydkigome	182	8	Darwinian	darwinian	JJ
cord-264884-ydkigome	182	9	models	model	NNS
cord-264884-ydkigome	182	10	.	.	.
cord-264884-ydkigome	183	1	Although	although	IN
cord-264884-ydkigome	183	2	virologists	virologist	NNS
cord-264884-ydkigome	183	3	were	be	VBD
cord-264884-ydkigome	183	4	initially	initially	RB
cord-264884-ydkigome	183	5	attracted	attract	VBN
cord-264884-ydkigome	183	6	to	to	IN
cord-264884-ydkigome	183	7	quasispecies	quasispecie	NNS
cord-264884-ydkigome	183	8	models	model	NNS
cord-264884-ydkigome	183	9	,	,	,
cord-264884-ydkigome	183	10	many	many	JJ
cord-264884-ydkigome	183	11	evolutionary	evolutionary	JJ
cord-264884-ydkigome	183	12	biologists	biologist	NNS
cord-264884-ydkigome	183	13	were	be	VBD
cord-264884-ydkigome	183	14	initially	initially	RB
cord-264884-ydkigome	183	15	hostile	hostile	JJ
cord-264884-ydkigome	183	16	to	to	IN
cord-264884-ydkigome	183	17	the	the	DT
cord-264884-ydkigome	183	18	application	application	NN
cord-264884-ydkigome	183	19	of	of	IN
cord-264884-ydkigome	183	20	the	the	DT
cord-264884-ydkigome	183	21	quasispecies	quasispecie	NNS
cord-264884-ydkigome	183	22	concept	concept	NN
cord-264884-ydkigome	183	23	to	to	IN
cord-264884-ydkigome	183	24	evolution	evolution	NN
cord-264884-ydkigome	183	25	.	.	.
cord-264884-ydkigome	184	1	It	-PRON-	PRP
cord-264884-ydkigome	184	2	was	be	VBD
cord-264884-ydkigome	184	3	thought	think	VBN
cord-264884-ydkigome	184	4	that	that	IN
cord-264884-ydkigome	184	5	the	the	DT
cord-264884-ydkigome	184	6	classical	classical	JJ
cord-264884-ydkigome	184	7	mathematical	mathematical	JJ
cord-264884-ydkigome	184	8	models	model	NNS
cord-264884-ydkigome	184	9	of	of	IN
cord-264884-ydkigome	184	10	population	population	NN
cord-264884-ydkigome	184	11	biology	biology	NN
cord-264884-ydkigome	184	12	,	,	,
cord-264884-ydkigome	184	13	as	as	IN
cord-264884-ydkigome	184	14	originally	originally	RB
cord-264884-ydkigome	184	15	developed	develop	VBN
cord-264884-ydkigome	184	16	by	by	IN
cord-264884-ydkigome	184	17	Wright	Wright	NNP
cord-264884-ydkigome	184	18	and	and	CC
cord-264884-ydkigome	184	19	Fisher	Fisher	NNP
cord-264884-ydkigome	184	20	,	,	,
cord-264884-ydkigome	184	21	and	and	CC
cord-264884-ydkigome	184	22	later	later	RB
cord-264884-ydkigome	184	23	applied	apply	VBN
cord-264884-ydkigome	184	24	by	by	IN
cord-264884-ydkigome	184	25	Kimura	Kimura	NNP
cord-264884-ydkigome	184	26	and	and	CC
cord-264884-ydkigome	184	27	Maruyama	Maruyama	NNP
cord-264884-ydkigome	184	28	to	to	IN
cord-264884-ydkigome	184	29	asexual	asexual	JJ
cord-264884-ydkigome	184	30	haploid	haploid	JJ
cord-264884-ydkigome	184	31	populations	population	NNS
cord-264884-ydkigome	184	32	at	at	IN
cord-264884-ydkigome	184	33	the	the	DT
cord-264884-ydkigome	184	34	mutationselection	mutationselection	NN
cord-264884-ydkigome	184	35	balance	balance	NN
cord-264884-ydkigome	184	36	,	,	,
cord-264884-ydkigome	184	37	had	have	VBD
cord-264884-ydkigome	184	38	already	already	RB
cord-264884-ydkigome	184	39	fully	fully	RB
cord-264884-ydkigome	184	40	developed	develop	VBN
cord-264884-ydkigome	184	41	the	the	DT
cord-264884-ydkigome	184	42	needed	needed	JJ
cord-264884-ydkigome	184	43	models	model	NNS
cord-264884-ydkigome	184	44	and	and	CC
cord-264884-ydkigome	184	45	precluded	preclude	VBD
cord-264884-ydkigome	184	46	additional	additional	JJ
cord-264884-ydkigome	184	47	need	need	NN
cord-264884-ydkigome	184	48	for	for	IN
cord-264884-ydkigome	184	49	the	the	DT
cord-264884-ydkigome	184	50	quasispecies	quasispecies	NNP
cord-264884-ydkigome	184	51	concept	concept	NN
cord-264884-ydkigome	184	52	.	.	.
cord-264884-ydkigome	185	1	The	the	DT
cord-264884-ydkigome	185	2	classical	classical	JJ
cord-264884-ydkigome	185	3	models	model	NNS
cord-264884-ydkigome	185	4	were	be	VBD
cord-264884-ydkigome	185	5	thus	thus	RB
cord-264884-ydkigome	185	6	argued	argue	VBN
cord-264884-ydkigome	185	7	to	to	TO
cord-264884-ydkigome	185	8	provide	provide	VB
cord-264884-ydkigome	185	9	adequate	adequate	JJ
cord-264884-ydkigome	185	10	mathematical	mathematical	JJ
cord-264884-ydkigome	185	11	coverage	coverage	NN
cord-264884-ydkigome	185	12	for	for	IN
cord-264884-ydkigome	185	13	viruses	virus	NNS
cord-264884-ydkigome	185	14	,	,	,
cord-264884-ydkigome	185	15	including	include	VBG
cord-264884-ydkigome	185	16	quasispecies	quasispecie	NNS
cord-264884-ydkigome	185	17	and	and	CC
cord-264884-ydkigome	185	18	error	error	NN
cord-264884-ydkigome	185	19	threshold	threshold	NN
cord-264884-ydkigome	185	20	(	(	-LRB-
cord-264884-ydkigome	185	21	Wilke	Wilke	NNP
cord-264884-ydkigome	185	22	,	,	,
cord-264884-ydkigome	185	23	2005	2005	CD
cord-264884-ydkigome	185	24	)	)	-RRB-
cord-264884-ydkigome	185	25	.	.	.
cord-264884-ydkigome	186	1	However	however	RB
cord-264884-ydkigome	186	2	,	,	,
cord-264884-ydkigome	186	3	these	these	DT
cord-264884-ydkigome	186	4	two	two	CD
cord-264884-ydkigome	186	5	approaches	approach	NNS
cord-264884-ydkigome	186	6	differ	differ	VBP
cord-264884-ydkigome	186	7	fundamentally	fundamentally	RB
cord-264884-ydkigome	186	8	with	with	IN
cord-264884-ydkigome	186	9	regard	regard	NN
cord-264884-ydkigome	186	10	to	to	IN
cord-264884-ydkigome	186	11	the	the	DT
cord-264884-ydkigome	186	12	signifi	signifi	NNP
cord-264884-ydkigome	186	13	cance	cance	NN
cord-264884-ydkigome	186	14	of	of	IN
cord-264884-ydkigome	186	15	error	error	NN
cord-264884-ydkigome	186	16	-	-	HYPH
cord-264884-ydkigome	186	17	prone	prone	JJ
cord-264884-ydkigome	186	18	replication	replication	NN
cord-264884-ydkigome	186	19	and	and	CC
cord-264884-ydkigome	186	20	it	-PRON-	PRP
cord-264884-ydkigome	186	21	was	be	VBD
cord-264884-ydkigome	186	22	the	the	DT
cord-264884-ydkigome	186	23	quasispecies	quasispecie	NNS
cord-264884-ydkigome	186	24	approach	approach	NN
cord-264884-ydkigome	186	25	that	that	WDT
cord-264884-ydkigome	186	26	led	lead	VBD
cord-264884-ydkigome	186	27	to	to	IN
cord-264884-ydkigome	186	28	the	the	DT
cord-264884-ydkigome	186	29	clear	clear	JJ
cord-264884-ydkigome	186	30	experimental	experimental	JJ
cord-264884-ydkigome	186	31	establishment	establishment	NN
cord-264884-ydkigome	186	32	that	that	WDT
cord-264884-ydkigome	186	33	quasispecies	quasispecie	VBZ
cord-264884-ydkigome	186	34	selection	selection	NN
cord-264884-ydkigome	186	35	,	,	,
cord-264884-ydkigome	186	36	per	per	FW
cord-264884-ydkigome	186	37	se	se	FW
cord-264884-ydkigome	186	38	,	,	,
cord-264884-ydkigome	186	39	is	be	VBZ
cord-264884-ydkigome	186	40	important	important	JJ
cord-264884-ydkigome	186	41	for	for	IN
cord-264884-ydkigome	186	42	viral	viral	JJ
cord-264884-ydkigome	186	43	pathology	pathology	NN
cord-264884-ydkigome	186	44	and	and	CC
cord-264884-ydkigome	186	45	fi	fi	NN
cord-264884-ydkigome	186	46	tness	tness	NNP
cord-264884-ydkigome	186	47	(	(	-LRB-
cord-264884-ydkigome	186	48	see	see	VB
cord-264884-ydkigome	186	49	below	below	RB
cord-264884-ydkigome	186	50	)	)	-RRB-
cord-264884-ydkigome	186	51	.	.	.
cord-264884-ydkigome	187	1	The	the	DT
cord-264884-ydkigome	187	2	development	development	NN
cord-264884-ydkigome	187	3	of	of	IN
cord-264884-ydkigome	187	4	quasispecies	quasispecie	NNS
cord-264884-ydkigome	187	5	theory	theory	NN
cord-264884-ydkigome	187	6	to	to	IN
cord-264884-ydkigome	187	7	virology	virology	NN
cord-264884-ydkigome	187	8	does	do	VBZ
cord-264884-ydkigome	187	9	indeed	indeed	RB
cord-264884-ydkigome	187	10	demonstrate	demonstrate	VB
cord-264884-ydkigome	187	11	distinct	distinct	JJ
cord-264884-ydkigome	187	12	differences	difference	NNS
cord-264884-ydkigome	187	13	with	with	IN
cord-264884-ydkigome	187	14	population	population	NN
cord-264884-ydkigome	187	15	genetics	genetic	NNS
cord-264884-ydkigome	187	16	.	.	.
cord-264884-ydkigome	188	1	Various	various	JJ
cord-264884-ydkigome	188	2	phenomena	phenomenon	NNS
cord-264884-ydkigome	188	3	,	,	,
cord-264884-ydkigome	188	4	such	such	JJ
cord-264884-ydkigome	188	5	as	as	IN
cord-264884-ydkigome	188	6	complementation	complementation	NN
cord-264884-ydkigome	188	7	,	,	,
cord-264884-ydkigome	188	8	cooperation	cooperation	NN
cord-264884-ydkigome	188	9	,	,	,
cord-264884-ydkigome	188	10	competition	competition	NN
cord-264884-ydkigome	188	11	,	,	,
cord-264884-ydkigome	188	12	and	and	CC
cord-264884-ydkigome	188	13	even	even	RB
cord-264884-ydkigome	188	14	defective	defective	JJ
cord-264884-ydkigome	188	15	mediated	mediate	VBN
cord-264884-ydkigome	188	16	extinction	extinction	NN
cord-264884-ydkigome	188	17	(	(	-LRB-
cord-264884-ydkigome	188	18	Domingo	Domingo	NNP
cord-264884-ydkigome	188	19	et	et	NNP
cord-264884-ydkigome	188	20	al	al	NNP
cord-264884-ydkigome	188	21	.	.	NNP
cord-264884-ydkigome	188	22	,	,	,
cord-264884-ydkigome	188	23	2001	2001	CD
cord-264884-ydkigome	188	24	,	,	,
cord-264884-ydkigome	188	25	Domingo	Domingo	NNP
cord-264884-ydkigome	188	26	2006	2006	CD
cord-264884-ydkigome	188	27	Grande	Grande	NNP
cord-264884-ydkigome	188	28	-	-	HYPH
cord-264884-ydkigome	188	29	Perez	Perez	NNP
cord-264884-ydkigome	188	30	et	et	NNP
cord-264884-ydkigome	188	31	al	al	NNP
cord-264884-ydkigome	188	32	.	.	NNP
cord-264884-ydkigome	188	33	,	,	,
cord-264884-ydkigome	188	34	2005	2005	CD
cord-264884-ydkigome	188	35	)	)	-RRB-
cord-264884-ydkigome	188	36	have	have	VBP
cord-264884-ydkigome	188	37	been	be	VBN
cord-264884-ydkigome	188	38	observed	observe	VBN
cord-264884-ydkigome	188	39	,	,	,
cord-264884-ydkigome	188	40	all	all	DT
cord-264884-ydkigome	188	41	of	of	IN
cord-264884-ydkigome	188	42	which	which	WDT
cord-264884-ydkigome	188	43	fall	fall	VBP
cord-264884-ydkigome	188	44	outside	outside	IN
cord-264884-ydkigome	188	45	of	of	IN
cord-264884-ydkigome	188	46	the	the	DT
cord-264884-ydkigome	188	47	parameters	parameter	NNS
cord-264884-ydkigome	188	48	of	of	IN
cord-264884-ydkigome	188	49	classical	classical	JJ
cord-264884-ydkigome	188	50	population	population	NN
cord-264884-ydkigome	188	51	genetics	genetics	NN
cord-264884-ydkigome	188	52	.	.	.
cord-264884-ydkigome	189	1	Viral	viral	JJ
cord-264884-ydkigome	189	2	fi	fi	NN
cord-264884-ydkigome	189	3	tness	tness	NN
cord-264884-ydkigome	189	4	has	have	VBZ
cord-264884-ydkigome	189	5	indeed	indeed	RB
cord-264884-ydkigome	189	6	been	be	VBN
cord-264884-ydkigome	189	7	shown	show	VBN
cord-264884-ydkigome	189	8	to	to	TO
cord-264884-ydkigome	189	9	be	be	VB
cord-264884-ydkigome	189	10	due	due	JJ
cord-264884-ydkigome	189	11	to	to	IN
cord-264884-ydkigome	189	12	interaction	interaction	NN
cord-264884-ydkigome	189	13	within	within	IN
cord-264884-ydkigome	189	14	a	a	DT
cord-264884-ydkigome	189	15	diverse	diverse	JJ
cord-264884-ydkigome	189	16	population	population	NN
cord-264884-ydkigome	189	17	,	,	,
cord-264884-ydkigome	189	18	and	and	CC
cord-264884-ydkigome	189	19	not	not	RB
cord-264884-ydkigome	189	20	to	to	IN
cord-264884-ydkigome	189	21	the	the	DT
cord-264884-ydkigome	189	22	fi	fi	NNP
cord-264884-ydkigome	189	23	ttest	ttest	NN
cord-264884-ydkigome	189	24	or	or	CC
cord-264884-ydkigome	189	25	master	master	NN
cord-264884-ydkigome	189	26	type	type	NN
cord-264884-ydkigome	189	27	.	.	.
cord-264884-ydkigome	190	1	And	and	CC
cord-264884-ydkigome	190	2	with	with	IN
cord-264884-ydkigome	190	3	RNA	RNA	NNP
cord-264884-ydkigome	190	4	viruses	virus	NNS
cord-264884-ydkigome	190	5	,	,	,
cord-264884-ydkigome	190	6	error	error	NN
cord-264884-ydkigome	190	7	threshold	threshold	NN
cord-264884-ydkigome	190	8	has	have	VBZ
cord-264884-ydkigome	190	9	become	become	VBN
cord-264884-ydkigome	190	10	a	a	DT
cord-264884-ydkigome	190	11	central	central	JJ
cord-264884-ydkigome	190	12	issue	issue	NN
cord-264884-ydkigome	190	13	(	(	-LRB-
cord-264884-ydkigome	190	14	Biebricher	Biebricher	NNP
cord-264884-ydkigome	190	15	and	and	CC
cord-264884-ydkigome	190	16	Eigen	Eigen	NNP
cord-264884-ydkigome	190	17	,	,	,
cord-264884-ydkigome	190	18	2005	2005	CD
cord-264884-ydkigome	190	19	)	)	-RRB-
cord-264884-ydkigome	190	20	.	.	.
cord-264884-ydkigome	191	1	The	the	DT
cord-264884-ydkigome	191	2	collective	collective	JJ
cord-264884-ydkigome	191	3	experience	experience	NN
cord-264884-ydkigome	191	4	has	have	VBZ
cord-264884-ydkigome	191	5	thus	thus	RB
cord-264884-ydkigome	191	6	made	make	VBN
cord-264884-ydkigome	191	7	clear	clear	JJ
cord-264884-ydkigome	191	8	the	the	DT
cord-264884-ydkigome	191	9	value	value	NN
cord-264884-ydkigome	191	10	of	of	IN
cord-264884-ydkigome	191	11	theory	theory	NN
cord-264884-ydkigome	191	12	to	to	IN
cord-264884-ydkigome	191	13	biology	biology	NN
cord-264884-ydkigome	191	14	.	.	.
cord-264884-ydkigome	192	1	Many	many	JJ
cord-264884-ydkigome	192	2	working	work	VBG
cord-264884-ydkigome	192	3	biologists	biologist	NNS
cord-264884-ydkigome	192	4	understand	understand	VBP
cord-264884-ydkigome	192	5	that	that	IN
cord-264884-ydkigome	192	6	life	life	NN
cord-264884-ydkigome	192	7	seems	seem	VBZ
cord-264884-ydkigome	192	8	overly	overly	RB
cord-264884-ydkigome	192	9	complex	complex	JJ
cord-264884-ydkigome	192	10	and	and	CC
cord-264884-ydkigome	192	11	defi	defi	NNP
cord-264884-ydkigome	192	12	es	es	XX
cord-264884-ydkigome	192	13	most	most	JJS
cord-264884-ydkigome	192	14	generalizations	generalization	NNS
cord-264884-ydkigome	192	15	.	.	.
cord-264884-ydkigome	193	1	Thus	thus	RB
cord-264884-ydkigome	193	2	they	-PRON-	PRP
cord-264884-ydkigome	193	3	do	do	VBP
cord-264884-ydkigome	193	4	not	not	RB
cord-264884-ydkigome	193	5	always	always	RB
cord-264884-ydkigome	193	6	appreciate	appreciate	VB
cord-264884-ydkigome	193	7	attempts	attempt	NNS
cord-264884-ydkigome	193	8	at	at	IN
cord-264884-ydkigome	193	9	general	general	JJ
cord-264884-ydkigome	193	10	theory	theory	NN
cord-264884-ydkigome	193	11	.	.	.
cord-264884-ydkigome	194	1	Although	although	IN
cord-264884-ydkigome	194	2	in	in	IN
cord-264884-ydkigome	194	3	reality	reality	NN
cord-264884-ydkigome	194	4	,	,	,
cord-264884-ydkigome	194	5	biology	biology	NN
cord-264884-ydkigome	194	6	may	may	MD
cord-264884-ydkigome	194	7	indeed	indeed	RB
cord-264884-ydkigome	194	8	often	often	RB
cord-264884-ydkigome	194	9	be	be	VB
cord-264884-ydkigome	194	10	too	too	RB
cord-264884-ydkigome	194	11	complex	complex	JJ
cord-264884-ydkigome	194	12	for	for	IN
cord-264884-ydkigome	194	13	accurate	accurate	JJ
cord-264884-ydkigome	194	14	theoretical	theoretical	JJ
cord-264884-ydkigome	194	15	predictions	prediction	NNS
cord-264884-ydkigome	194	16	,	,	,
cord-264884-ydkigome	194	17	these	these	DT
cord-264884-ydkigome	194	18	theories	theory	NNS
cord-264884-ydkigome	194	19	have	have	VBP
cord-264884-ydkigome	194	20	nevertheless	nevertheless	RB
cord-264884-ydkigome	194	21	clearly	clearly	RB
cord-264884-ydkigome	194	22	stimulated	stimulate	VBN
cord-264884-ydkigome	194	23	crucial	crucial	JJ
cord-264884-ydkigome	194	24	concepts	concept	NNS
cord-264884-ydkigome	194	25	and	and	CC
cord-264884-ydkigome	194	26	experimental	experimental	JJ
cord-264884-ydkigome	194	27	evaluation	evaluation	NN
cord-264884-ydkigome	194	28	,	,	,
cord-264884-ydkigome	194	29	and	and	CC
cord-264884-ydkigome	194	30	biologists	biologist	NNS
cord-264884-ydkigome	194	31	should	should	MD
cord-264884-ydkigome	194	32	be	be	VB
cord-264884-ydkigome	194	33	encouraged	encourage	VBN
cord-264884-ydkigome	194	34	by	by	IN
cord-264884-ydkigome	194	35	them	-PRON-	PRP
cord-264884-ydkigome	194	36	.	.	.
cord-264884-ydkigome	195	1	By	by	IN
cord-264884-ydkigome	195	2	providing	provide	VBG
cord-264884-ydkigome	195	3	new	new	JJ
cord-264884-ydkigome	195	4	ways	way	NNS
cord-264884-ydkigome	195	5	of	of	IN
cord-264884-ydkigome	195	6	thinking	thinking	NN
cord-264884-ydkigome	195	7	,	,	,
cord-264884-ydkigome	195	8	entirely	entirely	RB
cord-264884-ydkigome	195	9	new	new	JJ
cord-264884-ydkigome	195	10	experimental	experimental	JJ
cord-264884-ydkigome	195	11	approaches	approach	NNS
cord-264884-ydkigome	195	12	can	can	MD
cord-264884-ydkigome	195	13	be	be	VB
cord-264884-ydkigome	195	14	developed	develop	VBN
cord-264884-ydkigome	195	15	.	.	.
cord-264884-ydkigome	196	1	The	the	DT
cord-264884-ydkigome	196	2	existence	existence	NN
cord-264884-ydkigome	196	3	of	of	IN
cord-264884-ydkigome	196	4	error	error	NN
cord-264884-ydkigome	196	5	-	-	HYPH
cord-264884-ydkigome	196	6	prone	prone	JJ
cord-264884-ydkigome	196	7	replication	replication	NN
cord-264884-ydkigome	196	8	and	and	CC
cord-264884-ydkigome	196	9	quasispecies	quasispecie	NNS
cord-264884-ydkigome	196	10	also	also	RB
cord-264884-ydkigome	196	11	raises	raise	VBZ
cord-264884-ydkigome	196	12	the	the	DT
cord-264884-ydkigome	196	13	issue	issue	NN
cord-264884-ydkigome	196	14	of	of	IN
cord-264884-ydkigome	196	15	the	the	DT
cord-264884-ydkigome	196	16	conservation	conservation	NN
cord-264884-ydkigome	196	17	of	of	IN
cord-264884-ydkigome	196	18	information	information	NN
cord-264884-ydkigome	196	19	.	.	.
cord-264884-ydkigome	197	1	How	how	WRB
cord-264884-ydkigome	197	2	is	be	VBZ
cord-264884-ydkigome	197	3	information	information	NN
cord-264884-ydkigome	197	4	stability	stability	NN
cord-264884-ydkigome	197	5	and	and	CC
cord-264884-ydkigome	197	6	higher	high	JJR
cord-264884-ydkigome	197	7	fi	fi	NN
cord-264884-ydkigome	197	8	tness	tness	NN
cord-264884-ydkigome	197	9	attained	attain	VBD
cord-264884-ydkigome	197	10	with	with	IN
cord-264884-ydkigome	197	11	such	such	JJ
cord-264884-ydkigome	197	12	errors	error	NNS
cord-264884-ydkigome	197	13	?	?	.
cord-264884-ydkigome	198	1	How	how	WRB
cord-264884-ydkigome	198	2	can	can	MD
cord-264884-ydkigome	198	3	genetic	genetic	VB
cord-264884-ydkigome	198	4	complexity	complexity	NN
cord-264884-ydkigome	198	5	be	be	VB
cord-264884-ydkigome	198	6	created	create	VBN
cord-264884-ydkigome	198	7	in	in	IN
cord-264884-ydkigome	198	8	such	such	PDT
cord-264884-ydkigome	198	9	a	a	DT
cord-264884-ydkigome	198	10	circumstance	circumstance	NN
cord-264884-ydkigome	198	11	?	?	.
cord-264884-ydkigome	199	1	Can	Can	MD
cord-264884-ydkigome	199	2	cooperation	cooperation	NN
cord-264884-ydkigome	199	3	(	(	-LRB-
cord-264884-ydkigome	199	4	or	or	CC
cord-264884-ydkigome	199	5	consortia	consortia	NN
cord-264884-ydkigome	199	6	behavior	behavior	NN
cord-264884-ydkigome	199	7	)	)	-RRB-
cord-264884-ydkigome	199	8	result	result	VBP
cord-264884-ydkigome	199	9	from	from	IN
cord-264884-ydkigome	199	10	any	any	DT
cord-264884-ydkigome	199	11	of	of	IN
cord-264884-ydkigome	199	12	these	these	DT
cord-264884-ydkigome	199	13	models	model	NNS
cord-264884-ydkigome	199	14	?	?	.
cord-264884-ydkigome	200	1	These	these	DT
cord-264884-ydkigome	200	2	issues	issue	NNS
cord-264884-ydkigome	200	3	have	have	VBP
cord-264884-ydkigome	200	4	yet	yet	RB
cord-264884-ydkigome	200	5	to	to	TO
cord-264884-ydkigome	200	6	be	be	VB
cord-264884-ydkigome	200	7	resolved	resolve	VBN
cord-264884-ydkigome	200	8	.	.	.
cord-264884-ydkigome	201	1	Some	some	DT
cord-264884-ydkigome	201	2	interesting	interesting	JJ
cord-264884-ydkigome	201	3	suggestions	suggestion	NNS
cord-264884-ydkigome	201	4	,	,	,
cord-264884-ydkigome	201	5	however	however	RB
cord-264884-ydkigome	201	6	,	,	,
cord-264884-ydkigome	201	7	have	have	VBP
cord-264884-ydkigome	201	8	been	be	VBN
cord-264884-ydkigome	201	9	proposed	propose	VBN
cord-264884-ydkigome	201	10	.	.	.
cord-264884-ydkigome	202	1	One	one	CD
cord-264884-ydkigome	202	2	involved	involved	JJ
cord-264884-ydkigome	202	3	cooperative	cooperative	JJ
cord-264884-ydkigome	202	4	evolution	evolution	NN
cord-264884-ydkigome	202	5	that	that	WDT
cord-264884-ydkigome	202	6	results	result	VBZ
cord-264884-ydkigome	202	7	from	from	IN
cord-264884-ydkigome	202	8	ligated	ligated	JJ
cord-264884-ydkigome	202	9	genomes	genome	NNS
cord-264884-ydkigome	202	10	.	.	.
cord-264884-ydkigome	203	1	A	a	DT
cord-264884-ydkigome	203	2	model	model	NN
cord-264884-ydkigome	203	3	was	be	VBD
cord-264884-ydkigome	203	4	proposed	propose	VBN
cord-264884-ydkigome	203	5	in	in	IN
cord-264884-ydkigome	203	6	2000	2000	CD
cord-264884-ydkigome	203	7	by	by	IN
cord-264884-ydkigome	203	8	Stadler	Stadler	NNP
cord-264884-ydkigome	203	9	and	and	CC
cord-264884-ydkigome	203	10	Schuster	Schuster	NNP
cord-264884-ydkigome	203	11	in	in	IN
cord-264884-ydkigome	203	12	which	which	WDT
cord-264884-ydkigome	203	13	they	-PRON-	PRP
cord-264884-ydkigome	203	14	considered	consider	VBD
cord-264884-ydkigome	203	15	the	the	DT
cord-264884-ydkigome	203	16	dynamics	dynamic	NNS
cord-264884-ydkigome	203	17	of	of	IN
cord-264884-ydkigome	203	18	replicator	replicator	NN
cord-264884-ydkigome	203	19	networks	network	NNS
cord-264884-ydkigome	203	20	resulting	result	VBG
cord-264884-ydkigome	203	21	from	from	IN
cord-264884-ydkigome	203	22	higher	high	JJR
cord-264884-ydkigome	203	23	order	order	NN
cord-264884-ydkigome	203	24	reactions	reaction	NNS
cord-264884-ydkigome	203	25	involving	involve	VBG
cord-264884-ydkigome	203	26	the	the	DT
cord-264884-ydkigome	203	27	templated	templated	JJ
cord-264884-ydkigome	203	28	ligation	ligation	NN
cord-264884-ydkigome	203	29	of	of	IN
cord-264884-ydkigome	203	30	smaller	small	JJR
cord-264884-ydkigome	203	31	genomes	genome	NNS
cord-264884-ydkigome	203	32	(	(	-LRB-
cord-264884-ydkigome	203	33	Stadler	Stadler	NNP
cord-264884-ydkigome	203	34	et	et	NNP
cord-264884-ydkigome	203	35	al	al	NNP
cord-264884-ydkigome	203	36	.	.	NNP
cord-264884-ydkigome	203	37	,	,	,
cord-264884-ydkigome	203	38	2000	2000	CD
cord-264884-ydkigome	203	39	)	)	-RRB-
cord-264884-ydkigome	203	40	.	.	.
cord-264884-ydkigome	204	1	Although	although	IN
cord-264884-ydkigome	204	2	this	this	DT
cord-264884-ydkigome	204	3	was	be	VBD
cord-264884-ydkigome	204	4	based	base	VBN
cord-264884-ydkigome	204	5	on	on	IN
cord-264884-ydkigome	204	6	concepts	concept	NNS
cord-264884-ydkigome	204	7	such	such	JJ
cord-264884-ydkigome	204	8	as	as	IN
cord-264884-ydkigome	204	9	triple	triple	RB
cord-264884-ydkigome	204	10	-	-	HYPH
cord-264884-ydkigome	204	11	stranded	strand	VBN
cord-264884-ydkigome	204	12	nucleic	nucleic	JJ
cord-264884-ydkigome	204	13	acids	acid	NNS
cord-264884-ydkigome	204	14	,	,	,
cord-264884-ydkigome	204	15	this	this	DT
cord-264884-ydkigome	204	16	clearly	clearly	RB
cord-264884-ydkigome	204	17	has	have	VBZ
cord-264884-ydkigome	204	18	some	some	DT
cord-264884-ydkigome	204	19	elements	element	NNS
cord-264884-ydkigome	204	20	that	that	WDT
cord-264884-ydkigome	204	21	also	also	RB
cord-264884-ydkigome	204	22	resemble	resemble	VBP
cord-264884-ydkigome	204	23	the	the	DT
cord-264884-ydkigome	204	24	ligation	ligation	NN
cord-264884-ydkigome	204	25	of	of	IN
cord-264884-ydkigome	204	26	recombinational	recombinational	JJ
cord-264884-ydkigome	204	27	processes	process	NNS
cord-264884-ydkigome	204	28	for	for	IN
cord-264884-ydkigome	204	29	DNA	dna	NN
cord-264884-ydkigome	204	30	phage	phage	NN
cord-264884-ydkigome	204	31	(	(	-LRB-
cord-264884-ydkigome	204	32	presented	present	VBN
cord-264884-ydkigome	204	33	below	below	RB
cord-264884-ydkigome	204	34	)	)	-RRB-
cord-264884-ydkigome	204	35	.	.	.
cord-264884-ydkigome	205	1	A	a	DT
cord-264884-ydkigome	205	2	most	most	RBS
cord-264884-ydkigome	205	3	interesting	interesting	JJ
cord-264884-ydkigome	205	4	outcome	outcome	NN
cord-264884-ydkigome	205	5	of	of	IN
cord-264884-ydkigome	205	6	these	these	DT
cord-264884-ydkigome	205	7	models	model	NNS
cord-264884-ydkigome	205	8	is	be	VBZ
cord-264884-ydkigome	205	9	that	that	IN
cord-264884-ydkigome	205	10	,	,	,
cord-264884-ydkigome	205	11	depending	depend	VBG
cord-264884-ydkigome	205	12	on	on	IN
cord-264884-ydkigome	205	13	initial	initial	JJ
cord-264884-ydkigome	205	14	replicator	replicator	NN
cord-264884-ydkigome	205	15	concentrations	concentration	NNS
cord-264884-ydkigome	205	16	,	,	,
cord-264884-ydkigome	205	17	permanent	permanent	JJ
cord-264884-ydkigome	205	18	coexistence	coexistence	NN
cord-264884-ydkigome	205	19	of	of	IN
cord-264884-ydkigome	205	20	replicators	replicator	NNS
cord-264884-ydkigome	205	21	could	could	MD
cord-264884-ydkigome	205	22	result	result	VB
cord-264884-ydkigome	205	23	in	in	IN
cord-264884-ydkigome	205	24	a	a	DT
cord-264884-ydkigome	205	25	cooperative	cooperative	JJ
cord-264884-ydkigome	205	26	network	network	NN
cord-264884-ydkigome	205	27	.	.	.
cord-264884-ydkigome	206	1	Such	such	JJ
cord-264884-ydkigome	206	2	cooperation	cooperation	NN
cord-264884-ydkigome	206	3	is	be	VBZ
cord-264884-ydkigome	206	4	a	a	DT
cord-264884-ydkigome	206	5	rare	rare	JJ
cord-264884-ydkigome	206	6	outcome	outcome	NN
cord-264884-ydkigome	206	7	for	for	IN
cord-264884-ydkigome	206	8	most	most	JJS
cord-264884-ydkigome	206	9	models	model	NNS
cord-264884-ydkigome	206	10	and	and	CC
cord-264884-ydkigome	206	11	given	give	VBN
cord-264884-ydkigome	206	12	the	the	DT
cord-264884-ydkigome	206	13	conclusion	conclusion	NN
cord-264884-ydkigome	206	14	that	that	IN
cord-264884-ydkigome	206	15	early	early	JJ
cord-264884-ydkigome	206	16	DNA	dna	NN
cord-264884-ydkigome	206	17	based	base	VBN
cord-264884-ydkigome	206	18	life	life	NN
cord-264884-ydkigome	206	19	was	be	VBD
cord-264884-ydkigome	206	20	a	a	DT
cord-264884-ydkigome	206	21	"	"	``
cord-264884-ydkigome	206	22	horizontal	horizontal	JJ
cord-264884-ydkigome	206	23	"	"	''
cord-264884-ydkigome	206	24	consortium	consortium	NN
cord-264884-ydkigome	206	25	,	,	,
cord-264884-ydkigome	206	26	such	such	JJ
cord-264884-ydkigome	206	27	models	model	NNS
cord-264884-ydkigome	206	28	are	be	VBP
cord-264884-ydkigome	206	29	of	of	IN
cord-264884-ydkigome	206	30	special	special	JJ
cord-264884-ydkigome	206	31	interest	interest	NN
cord-264884-ydkigome	206	32	.	.	.
cord-264884-ydkigome	207	1	The	the	DT
cord-264884-ydkigome	207	2	issue	issue	NN
cord-264884-ydkigome	207	3	of	of	IN
cord-264884-ydkigome	207	4	consortia	consortium	NNS
cord-264884-ydkigome	207	5	will	will	MD
cord-264884-ydkigome	207	6	come	come	VB
cord-264884-ydkigome	207	7	up	up	RP
cord-264884-ydkigome	207	8	often	often	RB
cord-264884-ydkigome	207	9	.	.	.
cord-264884-ydkigome	208	1	Consortia	consortia	NN
cord-264884-ydkigome	208	2	selection	selection	NN
cord-264884-ydkigome	208	3	directly	directly	RB
cord-264884-ydkigome	208	4	implies	imply	VBZ
cord-264884-ydkigome	208	5	cooperation	cooperation	NN
cord-264884-ydkigome	208	6	,	,	,
cord-264884-ydkigome	208	7	but	but	CC
cord-264884-ydkigome	208	8	cooperation	cooperation	NN
cord-264884-ydkigome	208	9	of	of	IN
cord-264884-ydkigome	208	10	selfi	selfi	NNP
cord-264884-ydkigome	208	11	sh	sh	NNP
cord-264884-ydkigome	208	12	replicators	replicator	NNS
cord-264884-ydkigome	208	13	presents	present	VBZ
cord-264884-ydkigome	208	14	dilemmas	dilemma	NNS
cord-264884-ydkigome	208	15	.	.	.
cord-264884-ydkigome	209	1	Replicator	replicator	NN
cord-264884-ydkigome	209	2	networks	network	NNS
cord-264884-ydkigome	209	3	with	with	IN
cord-264884-ydkigome	209	4	interaction	interaction	NN
cord-264884-ydkigome	209	5	functions	function	NNS
cord-264884-ydkigome	209	6	that	that	WDT
cord-264884-ydkigome	209	7	give	give	VBP
cord-264884-ydkigome	209	8	highly	highly	RB
cord-264884-ydkigome	209	9	non	non	JJ
cord-264884-ydkigome	209	10	-	-	JJ
cord-264884-ydkigome	209	11	linear	linear	JJ
cord-264884-ydkigome	209	12	dynamics	dynamic	NNS
cord-264884-ydkigome	209	13	can	can	MD
cord-264884-ydkigome	209	14	result	result	VB
cord-264884-ydkigome	209	15	in	in	IN
cord-264884-ydkigome	209	16	complex	complex	JJ
cord-264884-ydkigome	209	17	mixtures	mixture	NNS
cord-264884-ydkigome	209	18	,	,	,
cord-264884-ydkigome	209	19	with	with	IN
cord-264884-ydkigome	209	20	behaviors	behavior	NNS
cord-264884-ydkigome	209	21	ranging	range	VBG
cord-264884-ydkigome	209	22	from	from	IN
cord-264884-ydkigome	209	23	survival	survival	NN
cord-264884-ydkigome	209	24	of	of	IN
cord-264884-ydkigome	209	25	the	the	DT
cord-264884-ydkigome	209	26	fi	fi	NNP
cord-264884-ydkigome	209	27	ttest	ttest	NNP
cord-264884-ydkigome	209	28	to	to	IN
cord-264884-ydkigome	209	29	also	also	RB
cord-264884-ydkigome	209	30	including	include	VBG
cord-264884-ydkigome	209	31	attainment	attainment	JJ
cord-264884-ydkigome	209	32	of	of	IN
cord-264884-ydkigome	209	33	globally	globally	RB
cord-264884-ydkigome	209	34	stable	stable	JJ
cord-264884-ydkigome	209	35	equilibrium	equilibrium	NN
cord-264884-ydkigome	209	36	tantamount	tantamount	JJ
cord-264884-ydkigome	209	37	to	to	IN
cord-264884-ydkigome	209	38	permanent	permanent	JJ
cord-264884-ydkigome	209	39	coexistence	coexistence	NN
cord-264884-ydkigome	209	40	.	.	.
cord-264884-ydkigome	210	1	The	the	DT
cord-264884-ydkigome	210	2	fi	fi	NN
cord-264884-ydkigome	210	3	tness	tness	NN
cord-264884-ydkigome	210	4	of	of	IN
cord-264884-ydkigome	210	5	populations	population	NNS
cord-264884-ydkigome	210	6	,	,	,
cord-264884-ydkigome	210	7	however	however	RB
cord-264884-ydkigome	210	8	,	,	,
cord-264884-ydkigome	210	9	is	be	VBZ
cord-264884-ydkigome	210	10	inherent	inherent	JJ
cord-264884-ydkigome	210	11	to	to	IN
cord-264884-ydkigome	210	12	current	current	JJ
cord-264884-ydkigome	210	13	quasispecies	quasispecie	NNS
cord-264884-ydkigome	210	14	concepts	concept	NNS
cord-264884-ydkigome	210	15	in	in	IN
cord-264884-ydkigome	210	16	virology	virology	NN
cord-264884-ydkigome	210	17	.	.	.
cord-264884-ydkigome	211	1	There	there	EX
cord-264884-ydkigome	211	2	may	may	MD
cord-264884-ydkigome	211	3	also	also	RB
cord-264884-ydkigome	211	4	be	be	VB
cord-264884-ydkigome	211	5	other	other	JJ
cord-264884-ydkigome	211	6	ways	way	NNS
cord-264884-ydkigome	211	7	to	to	TO
cord-264884-ydkigome	211	8	explain	explain	VB
cord-264884-ydkigome	211	9	the	the	DT
cord-264884-ydkigome	211	10	genetic	genetic	JJ
cord-264884-ydkigome	211	11	origin	origin	NN
cord-264884-ydkigome	211	12	of	of	IN
cord-264884-ydkigome	211	13	cooperation	cooperation	NN
cord-264884-ydkigome	211	14	(	(	-LRB-
cord-264884-ydkigome	211	15	such	such	JJ
cord-264884-ydkigome	211	16	as	as	IN
cord-264884-ydkigome	211	17	stable	stable	JJ
cord-264884-ydkigome	211	18	persistence	persistence	NN
cord-264884-ydkigome	211	19	involving	involve	VBG
cord-264884-ydkigome	211	20	addiction	addiction	NN
cord-264884-ydkigome	211	21	strategies	strategy	NNS
cord-264884-ydkigome	211	22	)	)	-RRB-
cord-264884-ydkigome	211	23	.	.	.
cord-264884-ydkigome	212	1	The	the	DT
cord-264884-ydkigome	212	2	stable	stable	JJ
cord-264884-ydkigome	212	3	persistence	persistence	NN
cord-264884-ydkigome	212	4	of	of	IN
cord-264884-ydkigome	212	5	a	a	DT
cord-264884-ydkigome	212	6	genetic	genetic	JJ
cord-264884-ydkigome	212	7	parasite	parasite	NN
cord-264884-ydkigome	212	8	can	can	MD
cord-264884-ydkigome	212	9	compel	compel	VB
cord-264884-ydkigome	212	10	cooperation	cooperation	NN
cord-264884-ydkigome	212	11	and	and	CC
cord-264884-ydkigome	212	12	promote	promote	VB
cord-264884-ydkigome	212	13	the	the	DT
cord-264884-ydkigome	212	14	conservation	conservation	NN
cord-264884-ydkigome	212	15	of	of	IN
cord-264884-ydkigome	212	16	information	information	NN
cord-264884-ydkigome	212	17	(	(	-LRB-
cord-264884-ydkigome	212	18	see	see	VB
cord-264884-ydkigome	212	19	below	below	RB
cord-264884-ydkigome	212	20	)	)	-RRB-
cord-264884-ydkigome	212	21	.	.	.
cord-264884-ydkigome	213	1	The	the	DT
cord-264884-ydkigome	213	2	defi	defi	FW
cord-264884-ydkigome	213	3	nitions	nition	NNS
cord-264884-ydkigome	213	4	of	of	IN
cord-264884-ydkigome	213	5	fi	fi	NNP
cord-264884-ydkigome	213	6	tness	tness	NN
cord-264884-ydkigome	213	7	with	with	IN
cord-264884-ydkigome	213	8	respect	respect	NN
cord-264884-ydkigome	213	9	to	to	IN
cord-264884-ydkigome	213	10	a	a	DT
cord-264884-ydkigome	213	11	virus	virus	NN
cord-264884-ydkigome	213	12	in	in	IN
cord-264884-ydkigome	213	13	a	a	DT
cord-264884-ydkigome	213	14	natural	natural	JJ
cord-264884-ydkigome	213	15	habitat	habitat	NN
cord-264884-ydkigome	213	16	are	be	VBP
cord-264884-ydkigome	213	17	far	far	RB
cord-264884-ydkigome	213	18	from	from	IN
cord-264884-ydkigome	213	19	clear	clear	JJ
cord-264884-ydkigome	213	20	.	.	.
cord-264884-ydkigome	214	1	Although	although	IN
cord-264884-ydkigome	214	2	the	the	DT
cord-264884-ydkigome	214	3	concept	concept	NN
cord-264884-ydkigome	214	4	of	of	IN
cord-264884-ydkigome	214	5	relative	relative	JJ
cord-264884-ydkigome	214	6	replicative	replicative	JJ
cord-264884-ydkigome	214	7	fi	fi	NN
cord-264884-ydkigome	214	8	tness	tness	NN
cord-264884-ydkigome	214	9	is	be	VBZ
cord-264884-ydkigome	214	10	often	often	RB
cord-264884-ydkigome	214	11	applied	apply	VBN
cord-264884-ydkigome	214	12	to	to	IN
cord-264884-ydkigome	214	13	lab	lab	NN
cord-264884-ydkigome	214	14	experiments	experiment	NNS
cord-264884-ydkigome	214	15	of	of	IN
cord-264884-ydkigome	214	16	virus	virus	NN
cord-264884-ydkigome	214	17	growth	growth	NN
cord-264884-ydkigome	214	18	,	,	,
cord-264884-ydkigome	214	19	we	-PRON-	PRP
cord-264884-ydkigome	214	20	know	know	VBP
cord-264884-ydkigome	214	21	many	many	JJ
cord-264884-ydkigome	214	22	situations	situation	NNS
cord-264884-ydkigome	214	23	in	in	IN
cord-264884-ydkigome	214	24	which	which	WDT
cord-264884-ydkigome	214	25	virus	virus	NN
cord-264884-ydkigome	214	26	replication	replication	NN
cord-264884-ydkigome	214	27	is	be	VBZ
cord-264884-ydkigome	214	28	not	not	RB
cord-264884-ydkigome	214	29	maximized	maximize	VBN
cord-264884-ydkigome	214	30	in	in	IN
cord-264884-ydkigome	214	31	natural	natural	JJ
cord-264884-ydkigome	214	32	settings	setting	NNS
cord-264884-ydkigome	214	33	and	and	CC
cord-264884-ydkigome	214	34	many	many	JJ
cord-264884-ydkigome	214	35	viruses	virus	NNS
cord-264884-ydkigome	214	36	can	can	MD
cord-264884-ydkigome	214	37	exist	exist	VB
cord-264884-ydkigome	214	38	in	in	IN
cord-264884-ydkigome	214	39	relatively	relatively	RB
cord-264884-ydkigome	214	40	non	non	JJ
cord-264884-ydkigome	214	41	-	-	JJ
cord-264884-ydkigome	214	42	replicative	replicative	JJ
cord-264884-ydkigome	214	43	states	state	NNS
cord-264884-ydkigome	214	44	for	for	IN
cord-264884-ydkigome	214	45	long	long	JJ
cord-264884-ydkigome	214	46	periods	period	NNS
cord-264884-ydkigome	214	47	.	.	.
cord-264884-ydkigome	215	1	Even	even	RB
cord-264884-ydkigome	215	2	in	in	IN
cord-264884-ydkigome	215	3	the	the	DT
cord-264884-ydkigome	215	4	context	context	NN
cord-264884-ydkigome	215	5	of	of	IN
cord-264884-ydkigome	215	6	an	an	DT
cord-264884-ydkigome	215	7	acutely	acutely	RB
cord-264884-ydkigome	215	8	replicating	replicate	VBG
cord-264884-ydkigome	215	9	virus	virus	NN
cord-264884-ydkigome	215	10	in	in	IN
cord-264884-ydkigome	215	11	a	a	DT
cord-264884-ydkigome	215	12	host	host	NN
cord-264884-ydkigome	215	13	organism	organism	NN
cord-264884-ydkigome	215	14	,	,	,
cord-264884-ydkigome	215	15	the	the	DT
cord-264884-ydkigome	215	16	concept	concept	NN
cord-264884-ydkigome	215	17	of	of	IN
cord-264884-ydkigome	215	18	fi	fi	NNP
cord-264884-ydkigome	215	19	tness	tness	NN
cord-264884-ydkigome	215	20	is	be	VBZ
cord-264884-ydkigome	215	21	clearly	clearly	RB
cord-264884-ydkigome	215	22	conditional	conditional	JJ
cord-264884-ydkigome	215	23	,	,	,
cord-264884-ydkigome	215	24	as	as	IN
cord-264884-ydkigome	215	25	the	the	DT
cord-264884-ydkigome	215	26	virus	virus	NN
cord-264884-ydkigome	215	27	must	must	MD
cord-264884-ydkigome	215	28	replicate	replicate	VB
cord-264884-ydkigome	215	29	through	through	IN
cord-264884-ydkigome	215	30	various	various	JJ
cord-264884-ydkigome	215	31	in	in	IN
cord-264884-ydkigome	215	32	vivo	vivo	NN
cord-264884-ydkigome	215	33	habitats	habitat	NNS
cord-264884-ydkigome	215	34	that	that	WDT
cord-264884-ydkigome	215	35	can	can	MD
cord-264884-ydkigome	215	36	have	have	VB
cord-264884-ydkigome	215	37	opposing	oppose	VBG
cord-264884-ydkigome	215	38	selection	selection	NN
cord-264884-ydkigome	215	39	.	.	.
cord-264884-ydkigome	216	1	As	as	IN
cord-264884-ydkigome	216	2	presented	present	VBN
cord-264884-ydkigome	216	3	below	below	RB
cord-264884-ydkigome	216	4	,	,	,
cord-264884-ydkigome	216	5	in	in	IN
cord-264884-ydkigome	216	6	vivo	vivo	NN
cord-264884-ydkigome	216	7	models	model	NNS
cord-264884-ydkigome	216	8	that	that	WDT
cord-264884-ydkigome	216	9	study	study	VBP
cord-264884-ydkigome	216	10	fi	fi	NN
cord-264884-ydkigome	216	11	tness	tness	NN
cord-264884-ydkigome	216	12	and	and	CC
cord-264884-ydkigome	216	13	viral	viral	JJ
cord-264884-ydkigome	216	14	diversity	diversity	NN
cord-264884-ydkigome	216	15	have	have	VBP
cord-264884-ydkigome	216	16	clearly	clearly	RB
cord-264884-ydkigome	216	17	indicated	indicate	VBN
cord-264884-ydkigome	216	18	that	that	IN
cord-264884-ydkigome	216	19	diversity	diversity	NN
cord-264884-ydkigome	216	20	per	per	FW
cord-264884-ydkigome	216	21	se	se	FW
cord-264884-ydkigome	216	22	is	be	VBZ
cord-264884-ydkigome	216	23	important	important	JJ
cord-264884-ydkigome	216	24	and	and	CC
cord-264884-ydkigome	216	25	fi	fi	IN
cord-264884-ydkigome	216	26	tness	tness	NN
cord-264884-ydkigome	216	27	is	be	VBZ
cord-264884-ydkigome	216	28	the	the	DT
cord-264884-ydkigome	216	29	result	result	NN
cord-264884-ydkigome	216	30	of	of	IN
cord-264884-ydkigome	216	31	consortia	consortium	NNS
cord-264884-ydkigome	216	32	.	.	.
cord-264884-ydkigome	217	1	How	how	WRB
cord-264884-ydkigome	217	2	do	do	VBP
cord-264884-ydkigome	217	3	we	-PRON-	PRP
cord-264884-ydkigome	217	4	defi	defi	VB
cord-264884-ydkigome	217	5	ne	ne	NNP
cord-264884-ydkigome	217	6	such	such	JJ
cord-264884-ydkigome	217	7	fi	fi	NNP
cord-264884-ydkigome	217	8	tness	tness	NN
cord-264884-ydkigome	217	9	since	since	IN
cord-264884-ydkigome	217	10	the	the	DT
cord-264884-ydkigome	217	11	mixture	mixture	NN
cord-264884-ydkigome	217	12	clearly	clearly	RB
cord-264884-ydkigome	217	13	matters	matter	VBZ
cord-264884-ydkigome	217	14	?	?	.
cord-264884-ydkigome	218	1	Also	also	RB
cord-264884-ydkigome	218	2	,	,	,
cord-264884-ydkigome	218	3	how	how	WRB
cord-264884-ydkigome	218	4	do	do	VBP
cord-264884-ydkigome	218	5	we	-PRON-	PRP
cord-264884-ydkigome	218	6	defi	defi	VB
cord-264884-ydkigome	218	7	ne	ne	NNP
cord-264884-ydkigome	218	8	information	information	NN
cord-264884-ydkigome	218	9	content	content	NN
cord-264884-ydkigome	218	10	or	or	CC
cord-264884-ydkigome	218	11	integrity	integrity	NN
cord-264884-ydkigome	218	12	of	of	IN
cord-264884-ydkigome	218	13	a	a	DT
cord-264884-ydkigome	218	14	consortia	consortia	NN
cord-264884-ydkigome	218	15	?	?	.
cord-264884-ydkigome	219	1	Currently	currently	RB
cord-264884-ydkigome	219	2	,	,	,
cord-264884-ydkigome	219	3	we	-PRON-	PRP
cord-264884-ydkigome	219	4	can	can	MD
cord-264884-ydkigome	219	5	not	not	RB
cord-264884-ydkigome	219	6	.	.	.
cord-264884-ydkigome	220	1	In	in	IN
cord-264884-ydkigome	220	2	the	the	DT
cord-264884-ydkigome	220	3	lab	lab	NN
cord-264884-ydkigome	220	4	,	,	,
cord-264884-ydkigome	220	5	the	the	DT
cord-264884-ydkigome	220	6	viability	viability	NN
cord-264884-ydkigome	220	7	of	of	IN
cord-264884-ydkigome	220	8	a	a	DT
cord-264884-ydkigome	220	9	virus	virus	NN
cord-264884-ydkigome	220	10	is	be	VBZ
cord-264884-ydkigome	220	11	usually	usually	RB
cord-264884-ydkigome	220	12	measured	measure	VBN
cord-264884-ydkigome	220	13	by	by	IN
cord-264884-ydkigome	220	14	the	the	DT
cord-264884-ydkigome	220	15	ability	ability	NN
cord-264884-ydkigome	220	16	to	to	TO
cord-264884-ydkigome	220	17	produce	produce	VB
cord-264884-ydkigome	220	18	plaques	plaque	NNS
cord-264884-ydkigome	220	19	.	.	.
cord-264884-ydkigome	221	1	This	this	DT
cord-264884-ydkigome	221	2	has	have	VBZ
cord-264884-ydkigome	221	3	been	be	VBN
cord-264884-ydkigome	221	4	a	a	DT
cord-264884-ydkigome	221	5	crucial	crucial	JJ
cord-264884-ydkigome	221	6	and	and	CC
cord-264884-ydkigome	221	7	main	main	JJ
cord-264884-ydkigome	221	8	assay	assay	NN
cord-264884-ydkigome	221	9	for	for	IN
cord-264884-ydkigome	221	10	many	many	JJ
cord-264884-ydkigome	221	11	experimental	experimental	JJ
cord-264884-ydkigome	221	12	systems	system	NNS
cord-264884-ydkigome	221	13	that	that	WDT
cord-264884-ydkigome	221	14	study	study	VBP
cord-264884-ydkigome	221	15	virus	virus	NN
cord-264884-ydkigome	221	16	population	population	NN
cord-264884-ydkigome	221	17	.	.	.
cord-264884-ydkigome	222	1	Here	here	RB
cord-264884-ydkigome	222	2	,	,	,
cord-264884-ydkigome	222	3	the	the	DT
cord-264884-ydkigome	222	4	defi	defi	NNP
cord-264884-ydkigome	222	5	nition	nition	NN
cord-264884-ydkigome	222	6	of	of	IN
cord-264884-ydkigome	222	7	fi	fi	NNP
cord-264884-ydkigome	222	8	tness	tness	NNP
cord-264884-ydkigome	222	9	seems	seem	VBZ
cord-264884-ydkigome	222	10	direct	direct	JJ
cord-264884-ydkigome	222	11	:	:	:
cord-264884-ydkigome	222	12	plaque	plaque	NN
cord-264884-ydkigome	222	13	formation	formation	NN
cord-264884-ydkigome	222	14	equals	equal	VBZ
cord-264884-ydkigome	222	15	fi	fi	IN
cord-264884-ydkigome	222	16	tness	tness	NN
cord-264884-ydkigome	222	17	.	.	.
cord-264884-ydkigome	223	1	Various	various	JJ
cord-264884-ydkigome	223	2	highly	highly	RB
cord-264884-ydkigome	223	3	useful	useful	JJ
cord-264884-ydkigome	223	4	models	model	NNS
cord-264884-ydkigome	223	5	have	have	VBP
cord-264884-ydkigome	223	6	thus	thus	RB
cord-264884-ydkigome	223	7	been	be	VBN
cord-264884-ydkigome	223	8	defi	defi	NNP
cord-264884-ydkigome	223	9	ned	ned	NNP
cord-264884-ydkigome	223	10	and	and	CC
cord-264884-ydkigome	223	11	developed	develop	VBD
cord-264884-ydkigome	223	12	that	that	WDT
cord-264884-ydkigome	223	13	depend	depend	VBP
cord-264884-ydkigome	223	14	on	on	IN
cord-264884-ydkigome	223	15	these	these	DT
cord-264884-ydkigome	223	16	plaque	plaque	NN
cord-264884-ydkigome	223	17	assays	assay	NNS
cord-264884-ydkigome	223	18	(	(	-LRB-
cord-264884-ydkigome	223	19	see	see	VB
cord-264884-ydkigome	223	20	Chapter	chapter	NN
cord-264884-ydkigome	223	21	4	4	CD
cord-264884-ydkigome	223	22	)	)	-RRB-
cord-264884-ydkigome	223	23	.	.	.
cord-264884-ydkigome	224	1	With	with	IN
cord-264884-ydkigome	224	2	this	this	DT
cord-264884-ydkigome	224	3	,	,	,
cord-264884-ydkigome	224	4	populations	population	NNS
cord-264884-ydkigome	224	5	and	and	CC
cord-264884-ydkigome	224	6	population	population	NN
cord-264884-ydkigome	224	7	growth	growth	NN
cord-264884-ydkigome	224	8	are	be	VBP
cord-264884-ydkigome	224	9	defi	defi	NNP
cord-264884-ydkigome	224	10	ned	ned	NNP
cord-264884-ydkigome	224	11	as	as	IN
cord-264884-ydkigome	224	12	relative	relative	JJ
cord-264884-ydkigome	224	13	growth	growth	NN
cord-264884-ydkigome	224	14	of	of	IN
cord-264884-ydkigome	224	15	plaque	plaque	NN
cord-264884-ydkigome	224	16	-	-	HYPH
cord-264884-ydkigome	224	17	forming	form	VBG
cord-264884-ydkigome	224	18	units	unit	NNS
cord-264884-ydkigome	224	19	.	.	.
cord-264884-ydkigome	225	1	However	however	RB
cord-264884-ydkigome	225	2	,	,	,
cord-264884-ydkigome	225	3	the	the	DT
cord-264884-ydkigome	225	4	concept	concept	NN
cord-264884-ydkigome	225	5	has	have	VBZ
cord-264884-ydkigome	225	6	always	always	RB
cord-264884-ydkigome	225	7	been	be	VBN
cord-264884-ydkigome	225	8	problematic	problematic	JJ
cord-264884-ydkigome	225	9	when	when	WRB
cord-264884-ydkigome	225	10	considered	consider	VBN
cord-264884-ydkigome	225	11	from	from	IN
cord-264884-ydkigome	225	12	a	a	DT
cord-264884-ydkigome	225	13	natural	natural	JJ
cord-264884-ydkigome	225	14	virology	virology	NN
cord-264884-ydkigome	225	15	perspective	perspective	NN
cord-264884-ydkigome	225	16	.	.	.
cord-264884-ydkigome	226	1	Plaque	plaque	NN
cord-264884-ydkigome	226	2	formation	formation	NN
cord-264884-ydkigome	226	3	is	be	VBZ
cord-264884-ydkigome	226	4	clearly	clearly	RB
cord-264884-ydkigome	226	5	not	not	RB
cord-264884-ydkigome	226	6	equal	equal	JJ
cord-264884-ydkigome	226	7	to	to	TO
cord-264884-ydkigome	226	8	fi	fi	VB
cord-264884-ydkigome	226	9	tness	tness	NN
cord-264884-ydkigome	226	10	in	in	IN
cord-264884-ydkigome	226	11	natural	natural	JJ
cord-264884-ydkigome	226	12	habitats	habitat	NNS
cord-264884-ydkigome	226	13	.	.	.
cord-264884-ydkigome	227	1	There	there	EX
cord-264884-ydkigome	227	2	are	be	VBP
cord-264884-ydkigome	227	3	many	many	JJ
cord-264884-ydkigome	227	4	examples	example	NNS
cord-264884-ydkigome	227	5	of	of	IN
cord-264884-ydkigome	227	6	highly	highly	RB
cord-264884-ydkigome	227	7	successful	successful	JJ
cord-264884-ydkigome	227	8	viruses	virus	NNS
cord-264884-ydkigome	227	9	that	that	WDT
cord-264884-ydkigome	227	10	either	either	DT
cord-264884-ydkigome	227	11	plaque	plaque	NN
cord-264884-ydkigome	227	12	poorly	poorly	RB
cord-264884-ydkigome	227	13	or	or	CC
cord-264884-ydkigome	227	14	not	not	RB
cord-264884-ydkigome	227	15	at	at	RB
cord-264884-ydkigome	227	16	all	all	RB
cord-264884-ydkigome	227	17	.	.	.
cord-264884-ydkigome	228	1	Consider	consider	VB
cord-264884-ydkigome	228	2	the	the	DT
cord-264884-ydkigome	228	3	roughly	roughly	RB
cord-264884-ydkigome	228	4	100	100	CD
cord-264884-ydkigome	228	5	types	type	NNS
cord-264884-ydkigome	228	6	of	of	IN
cord-264884-ydkigome	228	7	human	human	JJ
cord-264884-ydkigome	228	8	papillomavirus	papillomavirus	NN
cord-264884-ydkigome	228	9	(	(	-LRB-
cord-264884-ydkigome	228	10	HPV	HPV	NNP
cord-264884-ydkigome	228	11	)	)	-RRB-
cord-264884-ydkigome	228	12	,	,	,
cord-264884-ydkigome	228	13	a	a	DT
cord-264884-ydkigome	228	14	simple	simple	JJ
cord-264884-ydkigome	228	15	small	small	JJ
cord-264884-ydkigome	228	16	circular	circular	JJ
cord-264884-ydkigome	228	17	DNA	dna	NN
cord-264884-ydkigome	228	18	virus	virus	NN
cord-264884-ydkigome	228	19	of	of	IN
cord-264884-ydkigome	228	20	epithelia	epithelium	NNS
cord-264884-ydkigome	228	21	;	;	:
cord-264884-ydkigome	228	22	this	this	DT
cord-264884-ydkigome	228	23	does	do	VBZ
cord-264884-ydkigome	228	24	not	not	RB
cord-264884-ydkigome	228	25	form	form	VB
cord-264884-ydkigome	228	26	plaques	plaque	NNS
cord-264884-ydkigome	228	27	in	in	IN
cord-264884-ydkigome	228	28	any	any	DT
cord-264884-ydkigome	228	29	known	known	JJ
cord-264884-ydkigome	228	30	system	system	NN
cord-264884-ydkigome	228	31	(	(	-LRB-
cord-264884-ydkigome	228	32	Chapter	chapter	NN
cord-264884-ydkigome	228	33	18	18	CD
cord-264884-ydkigome	228	34	)	)	-RRB-
cord-264884-ydkigome	228	35	.	.	.
cord-264884-ydkigome	229	1	HPV	HPV	NNP
cord-264884-ydkigome	229	2	is	be	VBZ
cord-264884-ydkigome	229	3	clearly	clearly	RB
cord-264884-ydkigome	229	4	fi	fi	NNP
cord-264884-ydkigome	229	5	t	t	NN
cord-264884-ydkigome	229	6	,	,	,
cord-264884-ydkigome	229	7	well	well	UH
cord-264884-ydkigome	229	8	adapted	adapt	VBN
cord-264884-ydkigome	229	9	to	to	IN
cord-264884-ydkigome	229	10	,	,	,
cord-264884-ydkigome	229	11	and	and	CC
cord-264884-ydkigome	229	12	stable	stable	JJ
cord-264884-ydkigome	229	13	in	in	IN
cord-264884-ydkigome	229	14	its	-PRON-	PRP$
cord-264884-ydkigome	229	15	human	human	JJ
cord-264884-ydkigome	229	16	host	host	NN
cord-264884-ydkigome	229	17	.	.	.
cord-264884-ydkigome	230	1	In	in	IN
cord-264884-ydkigome	230	2	addition	addition	NN
cord-264884-ydkigome	230	3	,	,	,
cord-264884-ydkigome	230	4	HPV	hpv	NN
cord-264884-ydkigome	230	5	evolution	evolution	NN
cord-264884-ydkigome	230	6	is	be	VBZ
cord-264884-ydkigome	230	7	phylogenetically	phylogenetically	RB
cord-264884-ydkigome	230	8	congruent	congruent	JJ
cord-264884-ydkigome	230	9	with	with	IN
cord-264884-ydkigome	230	10	their	-PRON-	PRP$
cord-264884-ydkigome	230	11	primate	primate	JJ
cord-264884-ydkigome	230	12	host	host	NN
cord-264884-ydkigome	230	13	,	,	,
cord-264884-ydkigome	230	14	as	as	IN
cord-264884-ydkigome	230	15	are	be	VBP
cord-264884-ydkigome	230	16	most	most	RBS
cord-264884-ydkigome	230	17	persistent	persistent	JJ
cord-264884-ydkigome	230	18	viral	viral	JJ
cord-264884-ydkigome	230	19	infections	infection	NNS
cord-264884-ydkigome	230	20	.	.	.
cord-264884-ydkigome	231	1	We	-PRON-	PRP
cord-264884-ydkigome	231	2	have	have	VBP
cord-264884-ydkigome	231	3	yet	yet	RB
cord-264884-ydkigome	231	4	to	to	TO
cord-264884-ydkigome	231	5	understand	understand	VB
cord-264884-ydkigome	231	6	the	the	DT
cord-264884-ydkigome	231	7	definition	definition	NN
cord-264884-ydkigome	231	8	of	of	IN
cord-264884-ydkigome	231	9	fi	fi	NN
cord-264884-ydkigome	231	10	tness	tness	NN
cord-264884-ydkigome	231	11	in	in	IN
cord-264884-ydkigome	231	12	this	this	DT
cord-264884-ydkigome	231	13	situation	situation	NN
cord-264884-ydkigome	231	14	.	.	.
cord-264884-ydkigome	232	1	In	in	IN
cord-264884-ydkigome	232	2	some	some	DT
cord-264884-ydkigome	232	3	cases	case	NNS
cord-264884-ydkigome	232	4	,	,	,
cord-264884-ydkigome	232	5	it	-PRON-	PRP
cord-264884-ydkigome	232	6	seems	seem	VBZ
cord-264884-ydkigome	232	7	selection	selection	NN
cord-264884-ydkigome	232	8	for	for	IN
cord-264884-ydkigome	232	9	plaque	plaque	NN
cord-264884-ydkigome	232	10	propagation	propagation	NN
cord-264884-ydkigome	232	11	has	have	VBZ
cord-264884-ydkigome	232	12	clearly	clearly	RB
cord-264884-ydkigome	232	13	resulted	result	VBN
cord-264884-ydkigome	232	14	in	in	IN
cord-264884-ydkigome	232	15	loss	loss	NN
cord-264884-ydkigome	232	16	of	of	IN
cord-264884-ydkigome	232	17	highly	highly	RB
cord-264884-ydkigome	232	18	conserved	conserve	VBN
cord-264884-ydkigome	232	19	genes	gene	NNS
cord-264884-ydkigome	232	20	;	;	:
cord-264884-ydkigome	232	21	such	such	JJ
cord-264884-ydkigome	232	22	as	as	IN
cord-264884-ydkigome	232	23	with	with	IN
cord-264884-ydkigome	232	24	the	the	DT
cord-264884-ydkigome	232	25	plaque	plaque	NN
cord-264884-ydkigome	232	26	-	-	HYPH
cord-264884-ydkigome	232	27	adapted	adapt	VBN
cord-264884-ydkigome	232	28	laboratory	laboratory	NN
cord-264884-ydkigome	232	29	strains	strain	NNS
cord-264884-ydkigome	232	30	of	of	IN
cord-264884-ydkigome	232	31	cytomegalovirus	cytomegalovirus	NNP
cord-264884-ydkigome	232	32	(	(	-LRB-
cord-264884-ydkigome	232	33	CMV	CMV	NNP
cord-264884-ydkigome	232	34	)	)	-RRB-
cord-264884-ydkigome	232	35	.	.	.
cord-264884-ydkigome	233	1	The	the	DT
cord-264884-ydkigome	233	2	problem	problem	NN
cord-264884-ydkigome	233	3	posed	pose	VBN
cord-264884-ydkigome	233	4	by	by	IN
cord-264884-ydkigome	233	5	viruses	virus	NNS
cord-264884-ydkigome	233	6	with	with	IN
cord-264884-ydkigome	233	7	ineffi	ineffi	NNP
cord-264884-ydkigome	233	8	cient	cient	NNP
cord-264884-ydkigome	233	9	plaque	plaque	NN
cord-264884-ydkigome	233	10	formation	formation	NN
cord-264884-ydkigome	233	11	is	be	VBZ
cord-264884-ydkigome	233	12	not	not	RB
cord-264884-ydkigome	233	13	limited	limited	JJ
cord-264884-ydkigome	233	14	to	to	IN
cord-264884-ydkigome	233	15	DNA	dna	NN
cord-264884-ydkigome	233	16	viruses	virus	NNS
cord-264884-ydkigome	233	17	.	.	.
cord-264884-ydkigome	234	1	Many	many	JJ
cord-264884-ydkigome	234	2	persisting	persist	VBG
cord-264884-ydkigome	234	3	RNA	rna	NN
cord-264884-ydkigome	234	4	viruses	virus	NNS
cord-264884-ydkigome	234	5	also	also	RB
cord-264884-ydkigome	234	6	do	do	VBP
cord-264884-ydkigome	234	7	not	not	RB
cord-264884-ydkigome	234	8	plaque	plaque	VB
cord-264884-ydkigome	234	9	well	well	RB
cord-264884-ydkigome	234	10	or	or	CC
cord-264884-ydkigome	234	11	at	at	RB
cord-264884-ydkigome	234	12	all	all	RB
cord-264884-ydkigome	234	13	,	,	,
cord-264884-ydkigome	234	14	such	such	JJ
cord-264884-ydkigome	234	15	as	as	IN
cord-264884-ydkigome	234	16	most	most	JJS
cord-264884-ydkigome	234	17	RNA	RNA	NNP
cord-264884-ydkigome	234	18	viruses	virus	NNS
cord-264884-ydkigome	234	19	of	of	IN
cord-264884-ydkigome	234	20	plants	plant	NNS
cord-264884-ydkigome	234	21	or	or	CC
cord-264884-ydkigome	234	22	many	many	JJ
cord-264884-ydkigome	234	23	insect	insect	NN
cord-264884-ydkigome	234	24	picorna	picorna	NN
cord-264884-ydkigome	234	25	-	-	HYPH
cord-264884-ydkigome	234	26	like	like	JJ
cord-264884-ydkigome	234	27	viruses	virus	NNS
cord-264884-ydkigome	234	28	,	,	,
cord-264884-ydkigome	234	29	such	such	JJ
cord-264884-ydkigome	234	30	as	as	IN
cord-264884-ydkigome	234	31	those	those	DT
cord-264884-ydkigome	234	32	found	find	VBN
cord-264884-ydkigome	234	33	in	in	IN
cord-264884-ydkigome	234	34	Drosophila	Drosophila	NNP
cord-264884-ydkigome	234	35	and	and	CC
cord-264884-ydkigome	234	36	bees	bee	NNS
cord-264884-ydkigome	234	37	(	(	-LRB-
cord-264884-ydkigome	234	38	which	which	WDT
cord-264884-ydkigome	234	39	also	also	RB
cord-264884-ydkigome	234	40	conserve	conserve	VBP
cord-264884-ydkigome	234	41	an	an	DT
cord-264884-ydkigome	234	42	extra	extra	JJ
cord-264884-ydkigome	234	43	ORF	orf	NN
cord-264884-ydkigome	234	44	)	)	-RRB-
cord-264884-ydkigome	234	45	.	.	.
cord-264884-ydkigome	235	1	Nor	nor	CC
cord-264884-ydkigome	235	2	do	do	VBP
cord-264884-ydkigome	235	3	most	most	JJS
cord-264884-ydkigome	235	4	persistent	persistent	JJ
cord-264884-ydkigome	235	5	infections	infection	NNS
cord-264884-ydkigome	235	6	make	make	VBP
cord-264884-ydkigome	235	7	lots	lot	NNS
cord-264884-ydkigome	235	8	of	of	IN
cord-264884-ydkigome	235	9	virus	virus	NN
cord-264884-ydkigome	235	10	.	.	.
cord-264884-ydkigome	236	1	Low	low	JJ
cord-264884-ydkigome	236	2	-	-	HYPH
cord-264884-ydkigome	236	3	level	level	NN
cord-264884-ydkigome	236	4	persistence	persistence	NN
cord-264884-ydkigome	236	5	,	,	,
cord-264884-ydkigome	236	6	such	such	JJ
cord-264884-ydkigome	236	7	as	as	IN
cord-264884-ydkigome	236	8	hantavirus	hantavirus	NN
cord-264884-ydkigome	236	9	in	in	IN
cord-264884-ydkigome	236	10	rodents	rodent	NNS
cord-264884-ydkigome	236	11	,	,	,
cord-264884-ydkigome	236	12	for	for	IN
cord-264884-ydkigome	236	13	example	example	NN
cord-264884-ydkigome	236	14	,	,	,
cord-264884-ydkigome	236	15	is	be	VBZ
cord-264884-ydkigome	236	16	common	common	JJ
cord-264884-ydkigome	236	17	(	(	-LRB-
cord-264884-ydkigome	236	18	Hart	Hart	NNP
cord-264884-ydkigome	236	19	and	and	CC
cord-264884-ydkigome	236	20	Bennett	Bennett	NNP
cord-264884-ydkigome	236	21	,	,	,
cord-264884-ydkigome	236	22	1999	1999	CD
cord-264884-ydkigome	236	23	)	)	-RRB-
cord-264884-ydkigome	236	24	.	.	.
cord-264884-ydkigome	237	1	Clearly	clearly	RB
cord-264884-ydkigome	237	2	,	,	,
cord-264884-ydkigome	237	3	our	-PRON-	PRP$
cord-264884-ydkigome	237	4	simplifying	simplify	VBG
cord-264884-ydkigome	237	5	assumptions	assumption	NNS
cord-264884-ydkigome	237	6	of	of	IN
cord-264884-ydkigome	237	7	viral	viral	JJ
cord-264884-ydkigome	237	8	fi	fi	NN
cord-264884-ydkigome	237	9	tness	tness	NN
cord-264884-ydkigome	237	10	and	and	CC
cord-264884-ydkigome	237	11	population	population	NN
cord-264884-ydkigome	237	12	dynamics	dynamic	NNS
cord-264884-ydkigome	237	13	can	can	MD
cord-264884-ydkigome	237	14	not	not	RB
cord-264884-ydkigome	237	15	apply	apply	VB
cord-264884-ydkigome	237	16	to	to	IN
cord-264884-ydkigome	237	17	these	these	DT
cord-264884-ydkigome	237	18	stable	stable	JJ
cord-264884-ydkigome	237	19	evolutionary	evolutionary	JJ
cord-264884-ydkigome	237	20	states	state	NNS
cord-264884-ydkigome	237	21	.	.	.
cord-264884-ydkigome	238	1	However	however	RB
cord-264884-ydkigome	238	2	,	,	,
cord-264884-ydkigome	238	3	if	if	IN
cord-264884-ydkigome	238	4	we	-PRON-	PRP
cord-264884-ydkigome	238	5	limit	limit	VBP
cord-264884-ydkigome	238	6	our	-PRON-	PRP$
cord-264884-ydkigome	238	7	defi	defi	NNP
cord-264884-ydkigome	238	8	nition	nition	NN
cord-264884-ydkigome	238	9	of	of	IN
cord-264884-ydkigome	238	10	viral	viral	JJ
cord-264884-ydkigome	238	11	fi	fi	NN
cord-264884-ydkigome	238	12	tness	tness	NN
cord-264884-ydkigome	238	13	to	to	IN
cord-264884-ydkigome	238	14	relative	relative	JJ
cord-264884-ydkigome	238	15	replication	replication	NN
cord-264884-ydkigome	238	16	or	or	CC
cord-264884-ydkigome	238	17	plaque	plaque	NN
cord-264884-ydkigome	238	18	formation	formation	NN
cord-264884-ydkigome	238	19	we	-PRON-	PRP
cord-264884-ydkigome	238	20	can	can	MD
cord-264884-ydkigome	238	21	perform	perform	VB
cord-264884-ydkigome	238	22	some	some	DT
cord-264884-ydkigome	238	23	clear	clear	JJ
cord-264884-ydkigome	238	24	and	and	CC
cord-264884-ydkigome	238	25	quantitative	quantitative	JJ
cord-264884-ydkigome	238	26	evaluations	evaluation	NNS
cord-264884-ydkigome	238	27	.	.	.
cord-264884-ydkigome	239	1	Experimental	experimental	JJ
cord-264884-ydkigome	239	2	evaluation	evaluation	NN
cord-264884-ydkigome	239	3	forces	force	VBZ
cord-264884-ydkigome	239	4	us	-PRON-	PRP
cord-264884-ydkigome	239	5	to	to	TO
cord-264884-ydkigome	239	6	study	study	VB
cord-264884-ydkigome	239	7	fi	fi	NN
cord-264884-ydkigome	239	8	tness	tness	NN
cord-264884-ydkigome	239	9	by	by	IN
cord-264884-ydkigome	239	10	only	only	RB
cord-264884-ydkigome	239	11	those	those	DT
cord-264884-ydkigome	239	12	defi	defi	NNP
cord-264884-ydkigome	239	13	nitions	nition	NNS
cord-264884-ydkigome	239	14	that	that	IN
cord-264884-ydkigome	239	15	we	-PRON-	PRP
cord-264884-ydkigome	239	16	can	can	MD
cord-264884-ydkigome	239	17	currently	currently	RB
cord-264884-ydkigome	239	18	measure	measure	VB
cord-264884-ydkigome	239	19	.	.	.
cord-264884-ydkigome	240	1	As	as	IN
cord-264884-ydkigome	240	2	fi	fi	NNP
cord-264884-ydkigome	240	3	tness	tness	NN
cord-264884-ydkigome	240	4	appears	appear	VBZ
cord-264884-ydkigome	240	5	to	to	TO
cord-264884-ydkigome	240	6	be	be	VB
cord-264884-ydkigome	240	7	a	a	DT
cord-264884-ydkigome	240	8	relativistic	relativistic	JJ
cord-264884-ydkigome	240	9	and	and	CC
cord-264884-ydkigome	240	10	transient	transient	JJ
cord-264884-ydkigome	240	11	concept	concept	NN
cord-264884-ydkigome	240	12	,	,	,
cord-264884-ydkigome	240	13	depending	depend	VBG
cord-264884-ydkigome	240	14	very	very	RB
cord-264884-ydkigome	240	15	much	much	RB
cord-264884-ydkigome	240	16	on	on	IN
cord-264884-ydkigome	240	17	the	the	DT
cord-264884-ydkigome	240	18	tissue	tissue	NN
cord-264884-ydkigome	240	19	,	,	,
cord-264884-ydkigome	240	20	time	time	NN
cord-264884-ydkigome	240	21	,	,	,
cord-264884-ydkigome	240	22	place	place	NN
cord-264884-ydkigome	240	23	,	,	,
cord-264884-ydkigome	240	24	extant	extant	JJ
cord-264884-ydkigome	240	25	adaptive	adaptive	JJ
cord-264884-ydkigome	240	26	and	and	CC
cord-264884-ydkigome	240	27	innate	innate	JJ
cord-264884-ydkigome	240	28	immunity	immunity	NN
cord-264884-ydkigome	240	29	,	,	,
cord-264884-ydkigome	240	30	and	and	CC
cord-264884-ydkigome	240	31	competition	competition	NN
cord-264884-ydkigome	240	32	,	,	,
cord-264884-ydkigome	240	33	it	-PRON-	PRP
cord-264884-ydkigome	240	34	is	be	VBZ
cord-264884-ydkigome	240	35	likely	likely	JJ
cord-264884-ydkigome	240	36	that	that	IN
cord-264884-ydkigome	240	37	we	-PRON-	PRP
cord-264884-ydkigome	240	38	can	can	MD
cord-264884-ydkigome	240	39	only	only	RB
cord-264884-ydkigome	240	40	measure	measure	VB
cord-264884-ydkigome	240	41	with	with	IN
cord-264884-ydkigome	240	42	any	any	DT
cord-264884-ydkigome	240	43	accuracy	accuracy	NN
cord-264884-ydkigome	240	44	one	one	CD
cord-264884-ydkigome	240	45	aspect	aspect	NN
cord-264884-ydkigome	240	46	of	of	IN
cord-264884-ydkigome	240	47	fi	fi	NN
cord-264884-ydkigome	240	48	tness	tness	NN
cord-264884-ydkigome	240	49	at	at	IN
cord-264884-ydkigome	240	50	any	any	DT
cord-264884-ydkigome	240	51	one	one	CD
cord-264884-ydkigome	240	52	time	time	NN
cord-264884-ydkigome	240	53	.	.	.
cord-264884-ydkigome	241	1	HIV	HIV	NNP
cord-264884-ydkigome	241	2	infection	infection	NN
cord-264884-ydkigome	241	3	of	of	IN
cord-264884-ydkigome	241	4	humans	human	NNS
cord-264884-ydkigome	241	5	shows	show	VBZ
cord-264884-ydkigome	241	6	evidence	evidence	NN
cord-264884-ydkigome	241	7	of	of	IN
cord-264884-ydkigome	241	8	this	this	DT
cord-264884-ydkigome	241	9	in	in	IN
cord-264884-ydkigome	241	10	that	that	IN
cord-264884-ydkigome	241	11	the	the	DT
cord-264884-ydkigome	241	12	R5	R5	NNP
cord-264884-ydkigome	241	13	virus	virus	NN
cord-264884-ydkigome	241	14	is	be	VBZ
cord-264884-ydkigome	241	15	more	more	JJR
cord-264884-ydkigome	241	16	fi	fi	NN
cord-264884-ydkigome	241	17	t	t	NN
cord-264884-ydkigome	241	18	for	for	IN
cord-264884-ydkigome	241	19	transmission	transmission	NN
cord-264884-ydkigome	241	20	and	and	CC
cord-264884-ydkigome	241	21	early	early	JJ
cord-264884-ydkigome	241	22	disease	disease	NN
cord-264884-ydkigome	241	23	whereas	whereas	IN
cord-264884-ydkigome	241	24	the	the	DT
cord-264884-ydkigome	241	25	X4	X4	NNP
cord-264884-ydkigome	241	26	virus	virus	NN
cord-264884-ydkigome	241	27	is	be	VBZ
cord-264884-ydkigome	241	28	fi	fi	NNP
cord-264884-ydkigome	241	29	t	t	NN
cord-264884-ydkigome	241	30	later	later	RB
cord-264884-ydkigome	241	31	during	during	IN
cord-264884-ydkigome	241	32	the	the	DT
cord-264884-ydkigome	241	33	AIDS	AIDS	NNP
cord-264884-ydkigome	241	34	disease	disease	NN
cord-264884-ydkigome	241	35	phase	phase	NN
cord-264884-ydkigome	241	36	.	.	.
cord-264884-ydkigome	242	1	Clearly	clearly	RB
cord-264884-ydkigome	242	2	conditional	conditional	JJ
cord-264884-ydkigome	242	3	,	,	,
cord-264884-ydkigome	242	4	time	time	NN
cord-264884-ydkigome	242	5	-	-	HYPH
cord-264884-ydkigome	242	6	dependent	dependent	JJ
cord-264884-ydkigome	242	7	issues	issue	NNS
cord-264884-ydkigome	242	8	relate	relate	VBP
cord-264884-ydkigome	242	9	to	to	TO
cord-264884-ydkigome	242	10	fi	fi	VB
cord-264884-ydkigome	242	11	tness	tness	NNP
cord-264884-ydkigome	242	12	defi	defi	NNP
cord-264884-ydkigome	242	13	nitions	nitions	NNP
cord-264884-ydkigome	242	14	.	.	.
cord-264884-ydkigome	243	1	However	however	RB
cord-264884-ydkigome	243	2	,	,	,
cord-264884-ydkigome	243	3	much	much	RB
cord-264884-ydkigome	243	4	more	more	RBR
cord-264884-ydkigome	243	5	problematic	problematic	JJ
cord-264884-ydkigome	243	6	is	be	VBZ
cord-264884-ydkigome	243	7	that	that	IN
cord-264884-ydkigome	243	8	we	-PRON-	PRP
cord-264884-ydkigome	243	9	have	have	VBP
cord-264884-ydkigome	243	10	no	no	DT
cord-264884-ydkigome	243	11	theory	theory	NN
cord-264884-ydkigome	243	12	for	for	IN
cord-264884-ydkigome	243	13	viral	viral	JJ
cord-264884-ydkigome	243	14	persistence	persistence	NN
cord-264884-ydkigome	243	15	or	or	CC
cord-264884-ydkigome	243	16	its	-PRON-	PRP$
cord-264884-ydkigome	243	17	fi	fi	NN
cord-264884-ydkigome	243	18	tness	tness	NN
cord-264884-ydkigome	243	19	.	.	.
cord-264884-ydkigome	244	1	We	-PRON-	PRP
cord-264884-ydkigome	244	2	lack	lack	VBP
cord-264884-ydkigome	244	3	specifi	specifi	NN
cord-264884-ydkigome	244	4	c	c	NN
cord-264884-ydkigome	244	5	or	or	CC
cord-264884-ydkigome	244	6	measurable	measurable	JJ
cord-264884-ydkigome	244	7	parameters	parameter	NNS
cord-264884-ydkigome	244	8	other	other	JJ
cord-264884-ydkigome	244	9	than	than	IN
cord-264884-ydkigome	244	10	the	the	DT
cord-264884-ydkigome	244	11	simple	simple	JJ
cord-264884-ydkigome	244	12	maintenance	maintenance	NN
cord-264884-ydkigome	244	13	of	of	IN
cord-264884-ydkigome	244	14	genetic	genetic	JJ
cord-264884-ydkigome	244	15	material	material	NN
cord-264884-ydkigome	244	16	.	.	.
cord-264884-ydkigome	245	1	Yet	yet	CC
cord-264884-ydkigome	245	2	it	-PRON-	PRP
cord-264884-ydkigome	245	3	seems	seem	VBZ
cord-264884-ydkigome	245	4	clear	clear	JJ
cord-264884-ydkigome	245	5	that	that	IN
cord-264884-ydkigome	245	6	some	some	DT
cord-264884-ydkigome	245	7	distinguishing	distinguishing	JJ
cord-264884-ydkigome	245	8	features	feature	NNS
cord-264884-ydkigome	245	9	of	of	IN
cord-264884-ydkigome	245	10	persistence	persistence	NN
cord-264884-ydkigome	245	11	can	can	MD
cord-264884-ydkigome	245	12	already	already	RB
cord-264884-ydkigome	245	13	be	be	VB
cord-264884-ydkigome	245	14	recognized	recognize	VBN
cord-264884-ydkigome	245	15	.	.	.
cord-264884-ydkigome	246	1	For	for	IN
cord-264884-ydkigome	246	2	example	example	NN
cord-264884-ydkigome	246	3	,	,	,
cord-264884-ydkigome	246	4	the	the	DT
cord-264884-ydkigome	246	5	possible	possible	JJ
cord-264884-ydkigome	246	6	participation	participation	NN
cord-264884-ydkigome	246	7	of	of	IN
cord-264884-ydkigome	246	8	viral	viral	JJ
cord-264884-ydkigome	246	9	defectives	defective	NNS
cord-264884-ydkigome	246	10	(	(	-LRB-
cord-264884-ydkigome	246	11	normally	normally	RB
cord-264884-ydkigome	246	12	considered	consider	VBN
cord-264884-ydkigome	246	13	unfi	unfi	NNP
cord-264884-ydkigome	246	14	t	t	NNP
cord-264884-ydkigome	246	15	)	)	-RRB-
cord-264884-ydkigome	246	16	,	,	,
cord-264884-ydkigome	246	17	which	which	WDT
cord-264884-ydkigome	246	18	in	in	IN
cord-264884-ydkigome	246	19	numerous	numerous	JJ
cord-264884-ydkigome	246	20	circumstances	circumstance	NNS
cord-264884-ydkigome	246	21	can	can	MD
cord-264884-ydkigome	246	22	modify	modify	VB
cord-264884-ydkigome	246	23	or	or	CC
cord-264884-ydkigome	246	24	mediate	mediate	VB
cord-264884-ydkigome	246	25	persistence	persistence	NN
cord-264884-ydkigome	246	26	,	,	,
cord-264884-ydkigome	246	27	would	would	MD
cord-264884-ydkigome	246	28	need	need	VB
cord-264884-ydkigome	246	29	to	to	TO
cord-264884-ydkigome	246	30	be	be	VB
cord-264884-ydkigome	246	31	included	include	VBN
cord-264884-ydkigome	246	32	.	.	.
cord-264884-ydkigome	247	1	Clearly	clearly	RB
cord-264884-ydkigome	247	2	,	,	,
cord-264884-ydkigome	247	3	a	a	DT
cord-264884-ydkigome	247	4	defective	defective	JJ
cord-264884-ydkigome	247	5	role	role	NN
cord-264884-ydkigome	247	6	in	in	IN
cord-264884-ydkigome	247	7	persistence	persistence	NN
cord-264884-ydkigome	247	8	would	would	MD
cord-264884-ydkigome	247	9	also	also	RB
cord-264884-ydkigome	247	10	preclude	preclude	VB
cord-264884-ydkigome	247	11	them	-PRON-	PRP
cord-264884-ydkigome	247	12	from	from	IN
cord-264884-ydkigome	247	13	being	be	VBG
cord-264884-ydkigome	247	14	considered	consider	VBN
cord-264884-ydkigome	247	15	as	as	RB
cord-264884-ydkigome	247	16	genetic	genetic	JJ
cord-264884-ydkigome	247	17	"	"	''
cord-264884-ydkigome	247	18	junk	junk	NN
cord-264884-ydkigome	247	19	,	,	,
cord-264884-ydkigome	247	20	"	"	''
cord-264884-ydkigome	247	21	or	or	CC
cord-264884-ydkigome	247	22	selfish	selfish	JJ
cord-264884-ydkigome	247	23	elements	element	NNS
cord-264884-ydkigome	247	24	,	,	,
cord-264884-ydkigome	247	25	since	since	IN
cord-264884-ydkigome	247	26	they	-PRON-	PRP
cord-264884-ydkigome	247	27	would	would	MD
cord-264884-ydkigome	247	28	then	then	RB
cord-264884-ydkigome	247	29	matter	matter	VB
cord-264884-ydkigome	247	30	in	in	IN
cord-264884-ydkigome	247	31	measurable	measurable	JJ
cord-264884-ydkigome	247	32	ways	way	NNS
cord-264884-ydkigome	247	33	to	to	IN
cord-264884-ydkigome	247	34	the	the	DT
cord-264884-ydkigome	247	35	biological	biological	JJ
cord-264884-ydkigome	247	36	outcome	outcome	NN
cord-264884-ydkigome	247	37	of	of	IN
cord-264884-ydkigome	247	38	virus	virus	NN
cord-264884-ydkigome	247	39	persistent	persistent	JJ
cord-264884-ydkigome	247	40	infection	infection	NN
cord-264884-ydkigome	247	41	.	.	.
cord-264884-ydkigome	248	1	Persistence	persistence	NN
cord-264884-ydkigome	248	2	also	also	RB
cord-264884-ydkigome	248	3	requires	require	VBZ
cord-264884-ydkigome	248	4	an	an	DT
cord-264884-ydkigome	248	5	extended	extended	JJ
cord-264884-ydkigome	248	6	duration	duration	NN
cord-264884-ydkigome	248	7	of	of	IN
cord-264884-ydkigome	248	8	infection	infection	NN
cord-264884-ydkigome	248	9	,	,	,
cord-264884-ydkigome	248	10	not	not	RB
cord-264884-ydkigome	248	11	simply	simply	RB
cord-264884-ydkigome	248	12	maximized	maximize	VBN
cord-264884-ydkigome	248	13	replication	replication	NN
cord-264884-ydkigome	248	14	.	.	.
cord-264884-ydkigome	249	1	In	in	IN
cord-264884-ydkigome	249	2	fact	fact	NN
cord-264884-ydkigome	249	3	,	,	,
cord-264884-ydkigome	249	4	persistence	persistence	NN
cord-264884-ydkigome	249	5	generally	generally	RB
cord-264884-ydkigome	249	6	requires	require	VBZ
cord-264884-ydkigome	249	7	mechanisms	mechanism	NNS
cord-264884-ydkigome	249	8	to	to	TO
cord-264884-ydkigome	249	9	limit	limit	VB
cord-264884-ydkigome	249	10	the	the	DT
cord-264884-ydkigome	249	11	replication	replication	NN
cord-264884-ydkigome	249	12	of	of	IN
cord-264884-ydkigome	249	13	at	at	IN
cord-264884-ydkigome	249	14	least	least	JJS
cord-264884-ydkigome	249	15	the	the	DT
cord-264884-ydkigome	249	16	same	same	JJ
cord-264884-ydkigome	249	17	virus	virus	NN
cord-264884-ydkigome	249	18	for	for	IN
cord-264884-ydkigome	249	19	at	at	IN
cord-264884-ydkigome	249	20	least	least	JJS
cord-264884-ydkigome	249	21	some	some	DT
cord-264884-ydkigome	249	22	time	time	NN
cord-264884-ydkigome	249	23	.	.	.
cord-264884-ydkigome	250	1	Thus	thus	RB
cord-264884-ydkigome	250	2	,	,	,
cord-264884-ydkigome	250	3	limited	limited	JJ
cord-264884-ydkigome	250	4	replication	replication	NN
cord-264884-ydkigome	250	5	must	must	MD
cord-264884-ydkigome	250	6	be	be	VB
cord-264884-ydkigome	250	7	an	an	DT
cord-264884-ydkigome	250	8	essential	essential	JJ
cord-264884-ydkigome	250	9	element	element	NN
cord-264884-ydkigome	250	10	for	for	IN
cord-264884-ydkigome	250	11	this	this	DT
cord-264884-ydkigome	250	12	life	life	NN
cord-264884-ydkigome	250	13	strategy	strategy	NN
cord-264884-ydkigome	250	14	.	.	.
cord-264884-ydkigome	251	1	In	in	IN
cord-264884-ydkigome	251	2	my	-PRON-	PRP$
cord-264884-ydkigome	251	3	judgment	judgment	NN
cord-264884-ydkigome	251	4	,	,	,
cord-264884-ydkigome	251	5	and	and	CC
cord-264884-ydkigome	251	6	much	much	RB
cord-264884-ydkigome	251	7	like	like	IN
cord-264884-ydkigome	251	8	the	the	DT
cord-264884-ydkigome	251	9	quasispecies	quasispecies	NNP
cord-264884-ydkigome	251	10	concept	concept	NN
cord-264884-ydkigome	251	11	,	,	,
cord-264884-ydkigome	251	12	the	the	DT
cord-264884-ydkigome	251	13	concept	concept	NN
cord-264884-ydkigome	251	14	of	of	IN
cord-264884-ydkigome	251	15	persistence	persistence	NN
cord-264884-ydkigome	251	16	will	will	MD
cord-264884-ydkigome	251	17	eventually	eventually	RB
cord-264884-ydkigome	251	18	be	be	VB
cord-264884-ydkigome	251	19	recognized	recognize	VBN
cord-264884-ydkigome	251	20	for	for	IN
cord-264884-ydkigome	251	21	the	the	DT
cord-264884-ydkigome	251	22	fundamental	fundamental	JJ
cord-264884-ydkigome	251	23	(	(	-LRB-
cord-264884-ydkigome	251	24	symbiotic	symbiotic	JJ
cord-264884-ydkigome	251	25	)	)	-RRB-
cord-264884-ydkigome	251	26	force	force	NN
cord-264884-ydkigome	251	27	it	-PRON-	PRP
cord-264884-ydkigome	251	28	represents	represent	VBZ
cord-264884-ydkigome	251	29	in	in	IN
cord-264884-ydkigome	251	30	virus	virus	NN
cord-264884-ydkigome	251	31	evolution	evolution	NN
cord-264884-ydkigome	251	32	.	.	.
cord-264884-ydkigome	252	1	The	the	DT
cord-264884-ydkigome	252	2	experimental	experimental	JJ
cord-264884-ydkigome	252	3	work	work	NN
cord-264884-ydkigome	252	4	of	of	IN
cord-264884-ydkigome	252	5	Domingo	Domingo	NNP
cord-264884-ydkigome	252	6	and	and	CC
cord-264884-ydkigome	252	7	Holland	Holland	NNP
cord-264884-ydkigome	252	8	spans	span	VBZ
cord-264884-ydkigome	252	9	the	the	DT
cord-264884-ydkigome	252	10	modern	modern	JJ
cord-264884-ydkigome	252	11	assessment	assessment	NN
cord-264884-ydkigome	252	12	of	of	IN
cord-264884-ydkigome	252	13	quasispecies	quasispecies	NNP
cord-264884-ydkigome	252	14	theory	theory	NN
cord-264884-ydkigome	252	15	that	that	WDT
cord-264884-ydkigome	252	16	occurred	occur	VBD
cord-264884-ydkigome	252	17	in	in	IN
cord-264884-ydkigome	252	18	the	the	DT
cord-264884-ydkigome	252	19	1980s	1980	NNS
cord-264884-ydkigome	252	20	and	and	CC
cord-264884-ydkigome	252	21	1990s	1990	NNS
cord-264884-ydkigome	252	22	.	.	.
cord-264884-ydkigome	253	1	These	these	DT
cord-264884-ydkigome	253	2	investigators	investigator	NNS
cord-264884-ydkigome	253	3	were	be	VBD
cord-264884-ydkigome	253	4	the	the	DT
cord-264884-ydkigome	253	5	chief	chief	JJ
cord-264884-ydkigome	253	6	proponents	proponent	NNS
cord-264884-ydkigome	253	7	of	of	IN
cord-264884-ydkigome	253	8	this	this	DT
cord-264884-ydkigome	253	9	theory	theory	NN
cord-264884-ydkigome	253	10	,	,	,
cord-264884-ydkigome	253	11	bringing	bring	VBG
cord-264884-ydkigome	253	12	it	-PRON-	PRP
cord-264884-ydkigome	253	13	to	to	IN
cord-264884-ydkigome	253	14	the	the	DT
cord-264884-ydkigome	253	15	attention	attention	NN
cord-264884-ydkigome	253	16	of	of	IN
cord-264884-ydkigome	253	17	the	the	DT
cord-264884-ydkigome	253	18	broader	broad	JJR
cord-264884-ydkigome	253	19	virology	virology	NN
cord-264884-ydkigome	253	20	community	community	NN
cord-264884-ydkigome	253	21	(	(	-LRB-
cord-264884-ydkigome	253	22	Chapter	chapter	NN
cord-264884-ydkigome	253	23	4	4	CD
cord-264884-ydkigome	253	24	)	)	-RRB-
cord-264884-ydkigome	253	25	.	.	.
cord-264884-ydkigome	254	1	This	this	DT
cord-264884-ydkigome	254	2	work	work	NN
cord-264884-ydkigome	254	3	has	have	VBZ
cord-264884-ydkigome	254	4	transformed	transform	VBN
cord-264884-ydkigome	254	5	our	-PRON-	PRP$
cord-264884-ydkigome	254	6	thinking	thinking	NN
cord-264884-ydkigome	254	7	and	and	CC
cord-264884-ydkigome	254	8	laid	lay	VBD
cord-264884-ydkigome	254	9	the	the	DT
cord-264884-ydkigome	254	10	experimental	experimental	JJ
cord-264884-ydkigome	254	11	foundations	foundation	NNS
cord-264884-ydkigome	254	12	that	that	WDT
cord-264884-ydkigome	254	13	we	-PRON-	PRP
cord-264884-ydkigome	254	14	now	now	RB
cord-264884-ydkigome	254	15	build	build	VBP
cord-264884-ydkigome	254	16	upon	upon	IN
cord-264884-ydkigome	254	17	.	.	.
cord-264884-ydkigome	255	1	This	this	DT
cord-264884-ydkigome	255	2	current	current	JJ
cord-264884-ydkigome	255	3	volume	volume	NN
cord-264884-ydkigome	255	4	is	be	VBZ
cord-264884-ydkigome	255	5	an	an	DT
cord-264884-ydkigome	255	6	extension	extension	NN
cord-264884-ydkigome	255	7	from	from	IN
cord-264884-ydkigome	255	8	an	an	DT
cord-264884-ydkigome	255	9	earlier	early	JJR
cord-264884-ydkigome	255	10	book	book	NN
cord-264884-ydkigome	255	11	on	on	IN
cord-264884-ydkigome	255	12	quasispecies	quasispecie	NNS
cord-264884-ydkigome	255	13	and	and	CC
cord-264884-ydkigome	255	14	now	now	RB
cord-264884-ydkigome	255	15	encompasses	encompass	VBZ
cord-264884-ydkigome	255	16	both	both	DT
cord-264884-ydkigome	255	17	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	255	18	and	and	CC
cord-264884-ydkigome	255	19	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	255	20	viruses	virus	NNS
cord-264884-ydkigome	255	21	.	.	.
cord-264884-ydkigome	256	1	Since	since	IN
cord-264884-ydkigome	256	2	early	early	JJ
cord-264884-ydkigome	256	3	experimental	experimental	JJ
cord-264884-ydkigome	256	4	phage	phage	NN
cord-264884-ydkigome	256	5	studies	study	NNS
cord-264884-ydkigome	256	6	provided	provide	VBD
cord-264884-ydkigome	256	7	the	the	DT
cord-264884-ydkigome	256	8	foundations	foundation	NNS
cord-264884-ydkigome	256	9	for	for	IN
cord-264884-ydkigome	256	10	quasispecies	quasispecie	NNS
cord-264884-ydkigome	256	11	theory	theory	NN
cord-264884-ydkigome	257	1	(	(	-LRB-
cord-264884-ydkigome	257	2	Eigen	Eigen	NNP
cord-264884-ydkigome	257	3	et	et	FW
cord-264884-ydkigome	257	4	al	al	NNP
cord-264884-ydkigome	257	5	.	.	NNP
cord-264884-ydkigome	257	6	,	,	,
cord-264884-ydkigome	257	7	1988	1988	CD
cord-264884-ydkigome	257	8	)	)	-RRB-
cord-264884-ydkigome	257	9	,	,	,
cord-264884-ydkigome	257	10	using	use	VBG
cord-264884-ydkigome	257	11	mathematical	mathematical	JJ
cord-264884-ydkigome	257	12	descriptions	description	NNS
cord-264884-ydkigome	257	13	(	(	-LRB-
cord-264884-ydkigome	257	14	differential	differential	JJ
cord-264884-ydkigome	257	15	equations	equation	NNS
cord-264884-ydkigome	257	16	)	)	-RRB-
cord-264884-ydkigome	257	17	of	of	IN
cord-264884-ydkigome	257	18	mutation	mutation	NN
cord-264884-ydkigome	257	19	rates	rate	NNS
cord-264884-ydkigome	257	20	in	in	IN
cord-264884-ydkigome	257	21	T	t	NN
cord-264884-ydkigome	257	22	-	-	HYPH
cord-264884-ydkigome	257	23	even	even	RB
cord-264884-ydkigome	257	24	phage	phage	NN
cord-264884-ydkigome	257	25	(	(	-LRB-
cord-264884-ydkigome	257	26	Luria	Luria	NNP
cord-264884-ydkigome	257	27	and	and	CC
cord-264884-ydkigome	257	28	Delbruck	Delbruck	NNP
cord-264884-ydkigome	257	29	,	,	,
cord-264884-ydkigome	257	30	1943	1943	CD
cord-264884-ydkigome	257	31	)	)	-RRB-
cord-264884-ydkigome	257	32	,	,	,
cord-264884-ydkigome	257	33	this	this	DT
cord-264884-ydkigome	257	34	inclusion	inclusion	NN
cord-264884-ydkigome	257	35	is	be	VBZ
cord-264884-ydkigome	257	36	appropriate	appropriate	JJ
cord-264884-ydkigome	257	37	.	.	.
cord-264884-ydkigome	258	1	Interestingly	interestingly	RB
cord-264884-ydkigome	258	2	,	,	,
cord-264884-ydkigome	258	3	a	a	DT
cord-264884-ydkigome	258	4	second	second	JJ
cord-264884-ydkigome	258	5	early	early	JJ
cord-264884-ydkigome	258	6	paper	paper	NN
cord-264884-ydkigome	258	7	measuring	measure	VBG
cord-264884-ydkigome	258	8	replication	replication	NN
cord-264884-ydkigome	258	9	rates	rate	NNS
cord-264884-ydkigome	258	10	by	by	IN
cord-264884-ydkigome	258	11	these	these	DT
cord-264884-ydkigome	258	12	same	same	JJ
cord-264884-ydkigome	258	13	authors	author	NNS
cord-264884-ydkigome	258	14	also	also	RB
cord-264884-ydkigome	258	15	noted	note	VBD
cord-264884-ydkigome	258	16	the	the	DT
cord-264884-ydkigome	258	17	problems	problem	NNS
cord-264884-ydkigome	258	18	of	of	IN
cord-264884-ydkigome	258	19	viral	viral	JJ
cord-264884-ydkigome	258	20	interference	interference	NN
cord-264884-ydkigome	258	21	and	and	CC
cord-264884-ydkigome	258	22	defectives	defective	NNS
cord-264884-ydkigome	258	23	(	(	-LRB-
cord-264884-ydkigome	258	24	Delbruck	Delbruck	NNP
cord-264884-ydkigome	258	25	,	,	,
cord-264884-ydkigome	258	26	1945	1945	CD
cord-264884-ydkigome	258	27	)	)	-RRB-
cord-264884-ydkigome	258	28	.	.	.
cord-264884-ydkigome	259	1	Other	other	JJ
cord-264884-ydkigome	259	2	early	early	JJ
cord-264884-ydkigome	259	3	experiments	experiment	NNS
cord-264884-ydkigome	259	4	of	of	IN
cord-264884-ydkigome	259	5	phage	phage	NN
cord-264884-ydkigome	259	6	RNA	rna	NN
cord-264884-ydkigome	259	7	polymerase	polymerase	NN
cord-264884-ydkigome	259	8	(	(	-LRB-
cord-264884-ydkigome	259	9	Batschelet	Batschelet	NNP
cord-264884-ydkigome	259	10	et	et	NNP
cord-264884-ydkigome	259	11	al	al	NNP
cord-264884-ydkigome	259	12	.	.	NNP
cord-264884-ydkigome	259	13	,	,	,
cord-264884-ydkigome	259	14	1976	1976	CD
cord-264884-ydkigome	259	15	)	)	-RRB-
cord-264884-ydkigome	259	16	,	,	,
cord-264884-ydkigome	259	17	especially	especially	RB
cord-264884-ydkigome	259	18	with	with	IN
cord-264884-ydkigome	260	1	RNA	RNA	NNP
cord-264884-ydkigome	260	2	phage	phage	NN
cord-264884-ydkigome	260	3	Qβ	Qβ	NNP
cord-264884-ydkigome	261	1	(	(	-LRB-
cord-264884-ydkigome	261	2	Domingo	Domingo	NNP
cord-264884-ydkigome	261	3	et	et	NNP
cord-264884-ydkigome	261	4	al	al	NNP
cord-264884-ydkigome	261	5	.	.	NNP
cord-264884-ydkigome	261	6	,	,	,
cord-264884-ydkigome	261	7	1978	1978	CD
cord-264884-ydkigome	261	8	)	)	-RRB-
cord-264884-ydkigome	261	9	,	,	,
cord-264884-ydkigome	261	10	helped	help	VBD
cord-264884-ydkigome	261	11	set	set	VB
cord-264884-ydkigome	261	12	the	the	DT
cord-264884-ydkigome	261	13	stage	stage	NN
cord-264884-ydkigome	261	14	for	for	IN
cord-264884-ydkigome	261	15	the	the	DT
cord-264884-ydkigome	261	16	subsequent	subsequent	JJ
cord-264884-ydkigome	261	17	experiments	experiment	NNS
cord-264884-ydkigome	261	18	of	of	IN
cord-264884-ydkigome	261	19	the	the	DT
cord-264884-ydkigome	261	20	1980s	1980	NNS
cord-264884-ydkigome	261	21	and	and	CC
cord-264884-ydkigome	261	22	1990s	1990	NNS
cord-264884-ydkigome	261	23	.	.	.
cord-264884-ydkigome	262	1	From	from	IN
cord-264884-ydkigome	262	2	the	the	DT
cord-264884-ydkigome	262	3	test	test	NN
cord-264884-ydkigome	262	4	tube	tube	NN
cord-264884-ydkigome	262	5	to	to	IN
cord-264884-ydkigome	262	6	mouse	mouse	NN
cord-264884-ydkigome	262	7	models	model	NNS
cord-264884-ydkigome	262	8	to	to	IN
cord-264884-ydkigome	262	9	the	the	DT
cord-264884-ydkigome	262	10	study	study	NN
cord-264884-ydkigome	262	11	of	of	IN
cord-264884-ydkigome	262	12	human	human	JJ
cord-264884-ydkigome	262	13	disease	disease	NN
cord-264884-ydkigome	262	14	,	,	,
cord-264884-ydkigome	262	15	the	the	DT
cord-264884-ydkigome	262	16	work	work	NN
cord-264884-ydkigome	262	17	of	of	IN
cord-264884-ydkigome	262	18	Domingo	Domingo	NNP
cord-264884-ydkigome	262	19	and	and	CC
cord-264884-ydkigome	262	20	colleagues	colleague	NNS
cord-264884-ydkigome	262	21	has	have	VBZ
cord-264884-ydkigome	262	22	spanned	span	VBN
cord-264884-ydkigome	262	23	the	the	DT
cord-264884-ydkigome	262	24	entire	entire	JJ
cord-264884-ydkigome	262	25	history	history	NN
cord-264884-ydkigome	262	26	of	of	IN
cord-264884-ydkigome	262	27	viral	viral	JJ
cord-264884-ydkigome	262	28	quasispecies	quasispecie	NNS
cord-264884-ydkigome	262	29	(	(	-LRB-
cord-264884-ydkigome	262	30	Domingo	Domingo	NNP
cord-264884-ydkigome	262	31	and	and	CC
cord-264884-ydkigome	262	32	Gomez	Gomez	NNP
cord-264884-ydkigome	262	33	,	,	,
cord-264884-ydkigome	262	34	2007	2007	CD
cord-264884-ydkigome	262	35	;	;	:
cord-264884-ydkigome	262	36	Chapter	chapter	NN
cord-264884-ydkigome	262	37	4	4	CD
cord-264884-ydkigome	262	38	)	)	-RRB-
cord-264884-ydkigome	262	39	.	.	.
cord-264884-ydkigome	263	1	Quasispecies	Quasispecies	NNP
cord-264884-ydkigome	263	2	deals	deal	VBZ
cord-264884-ydkigome	263	3	with	with	IN
cord-264884-ydkigome	263	4	the	the	DT
cord-264884-ydkigome	263	5	products	product	NNS
cord-264884-ydkigome	263	6	of	of	IN
cord-264884-ydkigome	263	7	error	error	NN
cord-264884-ydkigome	263	8	-	-	HYPH
cord-264884-ydkigome	263	9	prone	prone	JJ
cord-264884-ydkigome	263	10	replication	replication	NN
cord-264884-ydkigome	263	11	.	.	.
cord-264884-ydkigome	264	1	However	however	RB
cord-264884-ydkigome	264	2	,	,	,
cord-264884-ydkigome	264	3	it	-PRON-	PRP
cord-264884-ydkigome	264	4	is	be	VBZ
cord-264884-ydkigome	264	5	worth	worth	JJ
cord-264884-ydkigome	264	6	repeating	repeat	VBG
cord-264884-ydkigome	264	7	that	that	IN
cord-264884-ydkigome	264	8	products	product	NNS
cord-264884-ydkigome	264	9	of	of	IN
cord-264884-ydkigome	264	10	error	error	NN
cord-264884-ydkigome	264	11	-	-	HYPH
cord-264884-ydkigome	264	12	prone	prone	JJ
cord-264884-ydkigome	264	13	replication	replication	NN
cord-264884-ydkigome	264	14	are	be	VBP
cord-264884-ydkigome	264	15	not	not	RB
cord-264884-ydkigome	264	16	behaving	behave	VBG
cord-264884-ydkigome	264	17	in	in	IN
cord-264884-ydkigome	264	18	a	a	DT
cord-264884-ydkigome	264	19	simple	simple	JJ
cord-264884-ydkigome	264	20	"	"	``
cord-264884-ydkigome	264	21	selfish	selfish	JJ
cord-264884-ydkigome	264	22	DNA	dna	NN
cord-264884-ydkigome	264	23	"	"	''
cord-264884-ydkigome	264	24	capacity	capacity	NN
cord-264884-ydkigome	264	25	and	and	CC
cord-264884-ydkigome	264	26	are	be	VBP
cord-264884-ydkigome	264	27	not	not	RB
cord-264884-ydkigome	264	28	devoid	devoid	JJ
cord-264884-ydkigome	264	29	of	of	IN
cord-264884-ydkigome	264	30	biological	biological	JJ
cord-264884-ydkigome	264	31	relevance	relevance	NN
cord-264884-ydkigome	264	32	and	and	CC
cord-264884-ydkigome	264	33	phenotype	phenotype	NN
cord-264884-ydkigome	264	34	.	.	.
cord-264884-ydkigome	265	1	In	in	IN
cord-264884-ydkigome	265	2	their	-PRON-	PRP$
cord-264884-ydkigome	265	3	complex	complex	JJ
cord-264884-ydkigome	265	4	populations	population	NNS
cord-264884-ydkigome	265	5	,	,	,
cord-264884-ydkigome	265	6	they	-PRON-	PRP
cord-264884-ydkigome	265	7	create	create	VBP
cord-264884-ydkigome	265	8	clear	clear	JJ
cord-264884-ydkigome	265	9	and	and	CC
cord-264884-ydkigome	265	10	varied	varied	JJ
cord-264884-ydkigome	265	11	affects	affect	NNS
cord-264884-ydkigome	265	12	on	on	IN
cord-264884-ydkigome	265	13	viral	viral	JJ
cord-264884-ydkigome	265	14	adaptability	adaptability	NN
cord-264884-ydkigome	265	15	,	,	,
cord-264884-ydkigome	265	16	competition	competition	NN
cord-264884-ydkigome	265	17	,	,	,
cord-264884-ydkigome	265	18	and	and	CC
cord-264884-ydkigome	265	19	fi	fi	NNP
cord-264884-ydkigome	265	20	tness	tness	NN
cord-264884-ydkigome	265	21	.	.	.
cord-264884-ydkigome	266	1	Since	since	IN
cord-264884-ydkigome	266	2	quasispecies	quasispecie	NNS
cord-264884-ydkigome	266	3	necessarily	necessarily	RB
cord-264884-ydkigome	266	4	involve	involve	VBP
cord-264884-ydkigome	266	5	defective	defective	JJ
cord-264884-ydkigome	266	6	and	and	CC
cord-264884-ydkigome	266	7	mutant	mutant	JJ
cord-264884-ydkigome	266	8	virus	virus	NN
cord-264884-ydkigome	266	9	,	,	,
cord-264884-ydkigome	266	10	it	-PRON-	PRP
cord-264884-ydkigome	266	11	is	be	VBZ
cord-264884-ydkigome	266	12	easy	easy	JJ
cord-264884-ydkigome	266	13	(	(	-LRB-
cord-264884-ydkigome	266	14	and	and	CC
cord-264884-ydkigome	266	15	common	common	JJ
cord-264884-ydkigome	266	16	)	)	-RRB-
cord-264884-ydkigome	266	17	to	to	TO
cord-264884-ydkigome	266	18	think	think	VB
cord-264884-ydkigome	266	19	of	of	IN
cord-264884-ydkigome	266	20	these	these	DT
cord-264884-ydkigome	266	21	entities	entity	NNS
cord-264884-ydkigome	266	22	simply	simply	RB
cord-264884-ydkigome	266	23	as	as	IN
cord-264884-ydkigome	266	24	genetic	genetic	JJ
cord-264884-ydkigome	266	25	junk	junk	NN
cord-264884-ydkigome	266	26	(	(	-LRB-
cord-264884-ydkigome	266	27	Villarreal	Villarreal	NNP
cord-264884-ydkigome	266	28	,	,	,
cord-264884-ydkigome	266	29	2005	2005	CD
cord-264884-ydkigome	266	30	(	(	-LRB-
cord-264884-ydkigome	266	31	Villarreal	Villarreal	NNP
cord-264884-ydkigome	266	32	,	,	,
cord-264884-ydkigome	266	33	,	,	,
cord-264884-ydkigome	266	34	2006	2006	CD
cord-264884-ydkigome	266	35	.	.	.
cord-264884-ydkigome	267	1	Defective	defective	JJ
cord-264884-ydkigome	267	2	and	and	CC
cord-264884-ydkigome	267	3	even	even	RB
cord-264884-ydkigome	267	4	lethal	lethal	JJ
cord-264884-ydkigome	267	5	or	or	CC
cord-264884-ydkigome	267	6	interfering	interfering	JJ
cord-264884-ydkigome	267	7	variation	variation	NN
cord-264884-ydkigome	267	8	in	in	IN
cord-264884-ydkigome	267	9	viral	viral	JJ
cord-264884-ydkigome	267	10	genomes	genome	NNS
cord-264884-ydkigome	267	11	can	can	MD
cord-264884-ydkigome	267	12	contribute	contribute	VB
cord-264884-ydkigome	267	13	to	to	IN
cord-264884-ydkigome	267	14	adaptability	adaptability	NN
cord-264884-ydkigome	267	15	.	.	.
cord-264884-ydkigome	268	1	Thus	thus	RB
cord-264884-ydkigome	268	2	,	,	,
cord-264884-ydkigome	268	3	viruses	virus	NNS
cord-264884-ydkigome	268	4	can	can	MD
cord-264884-ydkigome	268	5	clearly	clearly	RB
cord-264884-ydkigome	268	6	adapt	adapt	VB
cord-264884-ydkigome	268	7	as	as	IN
cord-264884-ydkigome	268	8	a	a	DT
cord-264884-ydkigome	268	9	cloud	cloud	NN
cord-264884-ydkigome	268	10	with	with	IN
cord-264884-ydkigome	268	11	a	a	DT
cord-264884-ydkigome	268	12	mutant	mutant	JJ
cord-264884-ydkigome	268	13	spectra	spectra	NN
cord-264884-ydkigome	268	14	.	.	.
cord-264884-ydkigome	269	1	In	in	IN
cord-264884-ydkigome	269	2	addition	addition	NN
cord-264884-ydkigome	269	3	,	,	,
cord-264884-ydkigome	269	4	unending	unending	JJ
cord-264884-ydkigome	269	5	competition	competition	NN
cord-264884-ydkigome	269	6	and	and	CC
cord-264884-ydkigome	269	7	exclusion	exclusion	NN
cord-264884-ydkigome	269	8	,	,	,
cord-264884-ydkigome	269	9	consistent	consistent	JJ
cord-264884-ydkigome	269	10	with	with	IN
cord-264884-ydkigome	269	11	the	the	DT
cord-264884-ydkigome	269	12	Red	Red	NNP
cord-264884-ydkigome	269	13	Queen	Queen	NNP
cord-264884-ydkigome	269	14	hypothesis	hypothesis	NN
cord-264884-ydkigome	269	15	,	,	,
cord-264884-ydkigome	269	16	has	have	VBZ
cord-264884-ydkigome	269	17	also	also	RB
cord-264884-ydkigome	269	18	been	be	VBN
cord-264884-ydkigome	269	19	observed	observe	VBN
cord-264884-ydkigome	269	20	(	(	-LRB-
cord-264884-ydkigome	269	21	Clarke	Clarke	NNP
cord-264884-ydkigome	269	22	et	et	NNP
cord-264884-ydkigome	269	23	al	al	NNP
cord-264884-ydkigome	269	24	.	.	NNP
cord-264884-ydkigome	269	25	,	,	,
cord-264884-ydkigome	269	26	1994	1994	CD
cord-264884-ydkigome	269	27	)	)	-RRB-
cord-264884-ydkigome	269	28	.	.	.
cord-264884-ydkigome	270	1	The	the	DT
cord-264884-ydkigome	270	2	poliovirus	poliovirus	NN
cord-264884-ydkigome	270	3	-	-	HYPH
cord-264884-ydkigome	270	4	mouse	mouse	NN
cord-264884-ydkigome	270	5	model	model	NN
cord-264884-ydkigome	270	6	(	(	-LRB-
cord-264884-ydkigome	270	7	see	see	VB
cord-264884-ydkigome	270	8	below	below	RB
cord-264884-ydkigome	270	9	)	)	-RRB-
cord-264884-ydkigome	270	10	in	in	IN
cord-264884-ydkigome	270	11	particular	particular	JJ
cord-264884-ydkigome	270	12	has	have	VBZ
cord-264884-ydkigome	270	13	provided	provide	VBN
cord-264884-ydkigome	270	14	a	a	DT
cord-264884-ydkigome	270	15	solid	solid	JJ
cord-264884-ydkigome	270	16	experimental	experimental	JJ
cord-264884-ydkigome	270	17	system	system	NN
cord-264884-ydkigome	270	18	for	for	IN
cord-264884-ydkigome	270	19	evaluating	evaluate	VBG
cord-264884-ydkigome	270	20	the	the	DT
cord-264884-ydkigome	270	21	adaptive	adaptive	JJ
cord-264884-ydkigome	270	22	consequence	consequence	NN
cord-264884-ydkigome	270	23	of	of	IN
cord-264884-ydkigome	270	24	quasispecies	quasispecie	NNS
cord-264884-ydkigome	270	25	.	.	.
cord-264884-ydkigome	271	1	It	-PRON-	PRP
cord-264884-ydkigome	271	2	is	be	VBZ
cord-264884-ydkigome	271	3	thus	thus	RB
cord-264884-ydkigome	271	4	ironic	ironic	JJ
cord-264884-ydkigome	271	5	that	that	IN
cord-264884-ydkigome	271	6	these	these	DT
cord-264884-ydkigome	271	7	same	same	JJ
cord-264884-ydkigome	271	8	experiments	experiment	NNS
cord-264884-ydkigome	271	9	have	have	VBP
cord-264884-ydkigome	271	10	also	also	RB
cord-264884-ydkigome	271	11	made	make	VBN
cord-264884-ydkigome	271	12	clear	clear	JJ
cord-264884-ydkigome	271	13	that	that	IN
cord-264884-ydkigome	271	14	the	the	DT
cord-264884-ydkigome	271	15	original	original	JJ
cord-264884-ydkigome	271	16	simplifying	simplify	VBG
cord-264884-ydkigome	271	17	assumptions	assumption	NNS
cord-264884-ydkigome	271	18	of	of	IN
cord-264884-ydkigome	271	19	the	the	DT
cord-264884-ydkigome	271	20	quasispecies	quasispecie	NNS
cord-264884-ydkigome	271	21	ordinary	ordinary	JJ
cord-264884-ydkigome	271	22	differential	differential	NN
cord-264884-ydkigome	271	23	as	as	IN
cord-264884-ydkigome	271	24	presented	present	VBN
cord-264884-ydkigome	271	25	by	by	IN
cord-264884-ydkigome	271	26	Eigen	Eigen	NNP
cord-264884-ydkigome	271	27	are	be	VBP
cord-264884-ydkigome	271	28	violated	violate	VBN
cord-264884-ydkigome	271	29	by	by	IN
cord-264884-ydkigome	271	30	the	the	DT
cord-264884-ydkigome	271	31	resulting	result	VBG
cord-264884-ydkigome	271	32	quasispecies	quasispecie	NNS
cord-264884-ydkigome	271	33	.	.	.
cord-264884-ydkigome	272	1	These	these	DT
cord-264884-ydkigome	272	2	products	product	NNS
cord-264884-ydkigome	272	3	of	of	IN
cord-264884-ydkigome	272	4	error	error	NN
cord-264884-ydkigome	272	5	-	-	HYPH
cord-264884-ydkigome	272	6	prone	prone	JJ
cord-264884-ydkigome	272	7	replication	replication	NN
cord-264884-ydkigome	272	8	do	do	VBP
cord-264884-ydkigome	272	9	indeed	indeed	RB
cord-264884-ydkigome	272	10	strongly	strongly	RB
cord-264884-ydkigome	272	11	interact	interact	VB
cord-264884-ydkigome	272	12	with	with	IN
cord-264884-ydkigome	272	13	each	each	DT
cord-264884-ydkigome	272	14	other	other	JJ
cord-264884-ydkigome	272	15	in	in	IN
cord-264884-ydkigome	272	16	both	both	DT
cord-264884-ydkigome	272	17	positive	positive	JJ
cord-264884-ydkigome	272	18	and	and	CC
cord-264884-ydkigome	272	19	negative	negative	JJ
cord-264884-ydkigome	272	20	ways	way	NNS
cord-264884-ydkigome	272	21	and	and	CC
cord-264884-ydkigome	272	22	such	such	JJ
cord-264884-ydkigome	272	23	interactions	interaction	NNS
cord-264884-ydkigome	272	24	contribute	contribute	VBP
cord-264884-ydkigome	272	25	signifi	signifi	NNP
cord-264884-ydkigome	272	26	cantly	cantly	RB
cord-264884-ydkigome	272	27	to	to	IN
cord-264884-ydkigome	272	28	the	the	DT
cord-264884-ydkigome	272	29	observed	observed	JJ
cord-264884-ydkigome	272	30	fi	fi	IN
cord-264884-ydkigome	272	31	tness	tness	NN
cord-264884-ydkigome	272	32	of	of	IN
cord-264884-ydkigome	272	33	the	the	DT
cord-264884-ydkigome	272	34	population	population	NN
cord-264884-ydkigome	272	35	.	.	.
cord-264884-ydkigome	273	1	Errors	error	NNS
cord-264884-ydkigome	273	2	and	and	CC
cord-264884-ydkigome	273	3	interaction	interaction	NN
cord-264884-ydkigome	273	4	are	be	VBP
cord-264884-ydkigome	273	5	important	important	JJ
cord-264884-ydkigome	273	6	for	for	IN
cord-264884-ydkigome	273	7	fi	fi	NN
cord-264884-ydkigome	273	8	tness	tness	NN
cord-264884-ydkigome	273	9	.	.	.
cord-264884-ydkigome	274	1	For	for	IN
cord-264884-ydkigome	274	2	example	example	NN
cord-264884-ydkigome	274	3	,	,	,
cord-264884-ydkigome	274	4	defectives	defective	NNS
cord-264884-ydkigome	274	5	have	have	VBP
cord-264884-ydkigome	274	6	been	be	VBN
cord-264884-ydkigome	274	7	reported	report	VBN
cord-264884-ydkigome	274	8	to	to	TO
cord-264884-ydkigome	274	9	mediate	mediate	VB
cord-264884-ydkigome	274	10	extermination	extermination	NN
cord-264884-ydkigome	274	11	of	of	IN
cord-264884-ydkigome	274	12	a	a	DT
cord-264884-ydkigome	274	13	competing	compete	VBG
cord-264884-ydkigome	274	14	wild	wild	JJ
cord-264884-ydkigome	274	15	-	-	HYPH
cord-264884-ydkigome	274	16	type	type	NN
cord-264884-ydkigome	274	17	virus	virus	NN
cord-264884-ydkigome	274	18	(	(	-LRB-
cord-264884-ydkigome	274	19	Grande	Grande	NNP
cord-264884-ydkigome	274	20	-	-	HYPH
cord-264884-ydkigome	274	21	Perez	Perez	NNP
cord-264884-ydkigome	274	22	et	et	NNP
cord-264884-ydkigome	274	23	al	al	NNP
cord-264884-ydkigome	274	24	.	.	NNP
cord-264884-ydkigome	274	25	,	,	,
cord-264884-ydkigome	274	26	2005	2005	CD
cord-264884-ydkigome	274	27	)	)	-RRB-
cord-264884-ydkigome	274	28	.	.	.
cord-264884-ydkigome	275	1	Complementation	Complementation	NNP
cord-264884-ydkigome	275	2	has	have	VBZ
cord-264884-ydkigome	275	3	also	also	RB
cord-264884-ydkigome	275	4	been	be	VBN
cord-264884-ydkigome	275	5	observed	observe	VBN
cord-264884-ydkigome	275	6	(	(	-LRB-
cord-264884-ydkigome	275	7	Garcia	Garcia	NNP
cord-264884-ydkigome	275	8	-	-	HYPH
cord-264884-ydkigome	275	9	Arriaza	Arriaza	NNP
cord-264884-ydkigome	275	10	et	et	NNP
cord-264884-ydkigome	275	11	al	al	NNP
cord-264884-ydkigome	275	12	.	.	NNP
cord-264884-ydkigome	275	13	,	,	,
cord-264884-ydkigome	275	14	2004	2004	CD
cord-264884-ydkigome	275	15	)	)	-RRB-
cord-264884-ydkigome	275	16	,	,	,
cord-264884-ydkigome	275	17	as	as	IN
cord-264884-ydkigome	275	18	has	have	VBZ
cord-264884-ydkigome	275	19	trans	trans	JJ
cord-264884-ydkigome	275	20	-dominant	-dominant	JJ
cord-264884-ydkigome	275	21	inhibition	inhibition	NN
cord-264884-ydkigome	275	22	(	(	-LRB-
cord-264884-ydkigome	275	23	Crowder	Crowder	NNP
cord-264884-ydkigome	275	24	and	and	CC
cord-264884-ydkigome	275	25	Kirkegaard	Kirkegaard	NNP
cord-264884-ydkigome	275	26	,	,	,
cord-264884-ydkigome	275	27	2005	2005	CD
cord-264884-ydkigome	275	28	)	)	-RRB-
cord-264884-ydkigome	275	29	.	.	.
cord-264884-ydkigome	276	1	Genetic	genetic	JJ
cord-264884-ydkigome	276	2	memory	memory	NN
cord-264884-ydkigome	276	3	of	of	IN
cord-264884-ydkigome	276	4	past	past	NN
cord-264884-ydkigome	276	5	selection	selection	NN
cord-264884-ydkigome	276	6	has	have	VBZ
cord-264884-ydkigome	276	7	been	be	VBN
cord-264884-ydkigome	276	8	shown	show	VBN
cord-264884-ydkigome	276	9	to	to	TO
cord-264884-ydkigome	276	10	be	be	VB
cord-264884-ydkigome	276	11	maintained	maintain	VBN
cord-264884-ydkigome	276	12	in	in	IN
cord-264884-ydkigome	276	13	a	a	DT
cord-264884-ydkigome	276	14	minority	minority	NN
cord-264884-ydkigome	276	15	of	of	IN
cord-264884-ydkigome	276	16	the	the	DT
cord-264884-ydkigome	276	17	population	population	NN
cord-264884-ydkigome	276	18	(	(	-LRB-
cord-264884-ydkigome	277	1	Ruiz	Ruiz	NNP
cord-264884-ydkigome	277	2	-	-	HYPH
cord-264884-ydkigome	277	3	Jarabo	Jarabo	NNP
cord-264884-ydkigome	277	4	et	et	NNP
cord-264884-ydkigome	277	5	al	al	NNP
cord-264884-ydkigome	277	6	.	.	NNP
cord-264884-ydkigome	277	7	,	,	,
cord-264884-ydkigome	277	8	2000	2000	CD
cord-264884-ydkigome	277	9	;	;	:
cord-264884-ydkigome	277	10	Briones	Briones	NNP
cord-264884-ydkigome	277	11	et	et	NNP
cord-264884-ydkigome	277	12	al	al	NNP
cord-264884-ydkigome	277	13	.	.	NNP
cord-264884-ydkigome	277	14	,	,	,
cord-264884-ydkigome	277	15	2006	2006	CD
cord-264884-ydkigome	277	16	)	)	-RRB-
cord-264884-ydkigome	277	17	.	.	.
cord-264884-ydkigome	278	1	Such	such	JJ
cord-264884-ydkigome	278	2	cooperative	cooperative	NN
cord-264884-ydkigome	278	3	(	(	-LRB-
cord-264884-ydkigome	278	4	consortia	consortia	NN
cord-264884-ydkigome	278	5	)	)	-RRB-
cord-264884-ydkigome	278	6	behavior	behavior	NN
cord-264884-ydkigome	278	7	,	,	,
cord-264884-ydkigome	278	8	which	which	WDT
cord-264884-ydkigome	278	9	can	can	MD
cord-264884-ydkigome	278	10	also	also	RB
cord-264884-ydkigome	278	11	depend	depend	VB
cord-264884-ydkigome	278	12	on	on	IN
cord-264884-ydkigome	278	13	unfi	unfi	NNP
cord-264884-ydkigome	278	14	t	t	NNP
cord-264884-ydkigome	278	15	or	or	CC
cord-264884-ydkigome	278	16	defective	defective	JJ
cord-264884-ydkigome	278	17	members	member	NNS
cord-264884-ydkigome	278	18	,	,	,
cord-264884-ydkigome	278	19	is	be	VBZ
cord-264884-ydkigome	278	20	at	at	IN
cord-264884-ydkigome	278	21	odds	odd	NNS
cord-264884-ydkigome	278	22	with	with	IN
cord-264884-ydkigome	278	23	classical	classical	JJ
cord-264884-ydkigome	278	24	Darwinian	darwinian	JJ
cord-264884-ydkigome	278	25	notions	notion	NNS
cord-264884-ydkigome	278	26	regarding	regard	VBG
cord-264884-ydkigome	278	27	survival	survival	NN
cord-264884-ydkigome	278	28	of	of	IN
cord-264884-ydkigome	278	29	the	the	DT
cord-264884-ydkigome	278	30	fi	fi	NNP
cord-264884-ydkigome	278	31	ttest	ttest	NNP
cord-264884-ydkigome	278	32	.	.	.
cord-264884-ydkigome	279	1	Consider	consider	VB
cord-264884-ydkigome	279	2	,	,	,
cord-264884-ydkigome	279	3	for	for	IN
cord-264884-ydkigome	279	4	example	example	NN
cord-264884-ydkigome	279	5	,	,	,
cord-264884-ydkigome	279	6	the	the	DT
cord-264884-ydkigome	279	7	fi	fi	XX
cord-264884-ydkigome	279	8	tness	tness	NN
cord-264884-ydkigome	279	9	of	of	IN
cord-264884-ydkigome	279	10	a	a	DT
cord-264884-ydkigome	279	11	defective	defective	JJ
cord-264884-ydkigome	279	12	or	or	CC
cord-264884-ydkigome	279	13	mutant	mutant	JJ
cord-264884-ydkigome	279	14	outside	outside	RB
cord-264884-ydkigome	279	15	of	of	IN
cord-264884-ydkigome	279	16	its	-PRON-	PRP$
cord-264884-ydkigome	279	17	role	role	NN
cord-264884-ydkigome	279	18	in	in	IN
cord-264884-ydkigome	279	19	a	a	DT
cord-264884-ydkigome	279	20	quasispecies	quasispecie	NNS
cord-264884-ydkigome	279	21	.	.	.
cord-264884-ydkigome	280	1	Such	such	PDT
cord-264884-ydkigome	280	2	a	a	DT
cord-264884-ydkigome	280	3	consideration	consideration	NN
cord-264884-ydkigome	280	4	ignores	ignore	VBZ
cord-264884-ydkigome	280	5	the	the	DT
cord-264884-ydkigome	280	6	very	very	JJ
cord-264884-ydkigome	280	7	nature	nature	NN
cord-264884-ydkigome	280	8	of	of	IN
cord-264884-ydkigome	280	9	a	a	DT
cord-264884-ydkigome	280	10	quasispecies	quasispecie	NNS
cord-264884-ydkigome	280	11	yet	yet	RB
cord-264884-ydkigome	281	1	it	-PRON-	PRP
cord-264884-ydkigome	281	2	is	be	VBZ
cord-264884-ydkigome	281	3	an	an	DT
cord-264884-ydkigome	281	4	issue	issue	NN
cord-264884-ydkigome	281	5	that	that	WDT
cord-264884-ydkigome	281	6	has	have	VBZ
cord-264884-ydkigome	281	7	often	often	RB
cord-264884-ydkigome	281	8	been	be	VBN
cord-264884-ydkigome	281	9	posed	pose	VBN
cord-264884-ydkigome	281	10	and	and	CC
cord-264884-ydkigome	281	11	experimentally	experimentally	RB
cord-264884-ydkigome	281	12	evaluated	evaluate	VBN
cord-264884-ydkigome	281	13	.	.	.
cord-264884-ydkigome	282	1	We	-PRON-	PRP
cord-264884-ydkigome	282	2	should	should	MD
cord-264884-ydkigome	282	3	refrain	refrain	VB
cord-264884-ydkigome	282	4	from	from	IN
cord-264884-ydkigome	282	5	thinking	think	VBG
cord-264884-ydkigome	282	6	of	of	IN
cord-264884-ydkigome	282	7	viruses	virus	NNS
cord-264884-ydkigome	282	8	simply	simply	RB
cord-264884-ydkigome	282	9	as	as	IN
cord-264884-ydkigome	282	10	fi	fi	NNP
cord-264884-ydkigome	282	11	t	t	NNP
cord-264884-ydkigome	282	12	or	or	CC
cord-264884-ydkigome	282	13	non	non	JJ
cord-264884-ydkigome	282	14	-	-	JJ
cord-264884-ydkigome	282	15	fi	fi	JJ
cord-264884-ydkigome	282	16	t	t	NN
cord-264884-ydkigome	282	17	individual	individual	JJ
cord-264884-ydkigome	282	18	types	type	NNS
cord-264884-ydkigome	282	19	since	since	IN
cord-264884-ydkigome	282	20	they	-PRON-	PRP
cord-264884-ydkigome	282	21	clearly	clearly	RB
cord-264884-ydkigome	282	22	exist	exist	VBP
cord-264884-ydkigome	282	23	in	in	IN
cord-264884-ydkigome	282	24	populations	population	NNS
cord-264884-ydkigome	282	25	that	that	WDT
cord-264884-ydkigome	282	26	provide	provide	VBP
cord-264884-ydkigome	282	27	population	population	NN
cord-264884-ydkigome	282	28	-	-	HYPH
cord-264884-ydkigome	282	29	based	base	VBN
cord-264884-ydkigome	282	30	adaptability	adaptability	NN
cord-264884-ydkigome	282	31	.	.	.
cord-264884-ydkigome	283	1	The	the	DT
cord-264884-ydkigome	283	2	selection	selection	NN
cord-264884-ydkigome	283	3	of	of	IN
cord-264884-ydkigome	283	4	viral	viral	JJ
cord-264884-ydkigome	283	5	consortia	consortium	NNS
cord-264884-ydkigome	283	6	or	or	CC
cord-264884-ydkigome	283	7	population	population	NN
cord-264884-ydkigome	283	8	raises	raise	VBZ
cord-264884-ydkigome	283	9	some	some	DT
cord-264884-ydkigome	283	10	fundamental	fundamental	JJ
cord-264884-ydkigome	283	11	issues	issue	NNS
cord-264884-ydkigome	283	12	for	for	IN
cord-264884-ydkigome	283	13	evolutionary	evolutionary	JJ
cord-264884-ydkigome	283	14	biology	biology	NN
cord-264884-ydkigome	283	15	.	.	.
cord-264884-ydkigome	284	1	This	this	DT
cord-264884-ydkigome	284	2	is	be	VBZ
cord-264884-ydkigome	284	3	essentially	essentially	RB
cord-264884-ydkigome	284	4	group	group	NN
cord-264884-ydkigome	284	5	selection	selection	NN
cord-264884-ydkigome	284	6	in	in	IN
cord-264884-ydkigome	284	7	which	which	WDT
cord-264884-ydkigome	284	8	a	a	DT
cord-264884-ydkigome	284	9	population	population	NN
cord-264884-ydkigome	284	10	,	,	,
cord-264884-ydkigome	284	11	not	not	RB
cord-264884-ydkigome	284	12	the	the	DT
cord-264884-ydkigome	284	13	fi	fi	NNP
cord-264884-ydkigome	284	14	ttest	ttest	NNP
cord-264884-ydkigome	284	15	individual	individual	NN
cord-264884-ydkigome	284	16	,	,	,
cord-264884-ydkigome	284	17	is	be	VBZ
cord-264884-ydkigome	284	18	selected	select	VBN
cord-264884-ydkigome	284	19	.	.	.
cord-264884-ydkigome	285	1	This	this	DT
cord-264884-ydkigome	285	2	view	view	NN
cord-264884-ydkigome	285	3	makes	make	VBZ
cord-264884-ydkigome	285	4	cooperation	cooperation	NN
cord-264884-ydkigome	285	5	or	or	CC
cord-264884-ydkigome	285	6	interaction	interaction	NN
cord-264884-ydkigome	285	7	of	of	IN
cord-264884-ydkigome	285	8	individual	individual	JJ
cord-264884-ydkigome	285	9	genomes	genome	NNS
cord-264884-ydkigome	285	10	a	a	DT
cord-264884-ydkigome	285	11	signifi	signifi	NN
cord-264884-ydkigome	285	12	ca	can	MD
cord-264884-ydkigome	285	13	nt	not	RB
cord-264884-ydkigome	285	14	component	component	NN
cord-264884-ydkigome	285	15	of	of	IN
cord-264884-ydkigome	285	16	selection	selection	NN
cord-264884-ydkigome	285	17	,	,	,
cord-264884-ydkigome	285	18	which	which	WDT
cord-264884-ydkigome	285	19	is	be	VBZ
cord-264884-ydkigome	285	20	not	not	RB
cord-264884-ydkigome	285	21	commonly	commonly	RB
cord-264884-ydkigome	285	22	thought	think	VBN
cord-264884-ydkigome	285	23	to	to	TO
cord-264884-ydkigome	285	24	be	be	VB
cord-264884-ydkigome	285	25	a	a	DT
cord-264884-ydkigome	285	26	general	general	JJ
cord-264884-ydkigome	285	27	or	or	CC
cord-264884-ydkigome	285	28	accepted	accepted	JJ
cord-264884-ydkigome	285	29	process	process	NN
cord-264884-ydkigome	285	30	in	in	IN
cord-264884-ydkigome	285	31	evolution	evolution	NN
cord-264884-ydkigome	285	32	.	.	.
cord-264884-ydkigome	286	1	Yet	yet	RB
cord-264884-ydkigome	286	2	population	population	NN
cord-264884-ydkigome	286	3	selection	selection	NN
cord-264884-ydkigome	286	4	is	be	VBZ
cord-264884-ydkigome	286	5	no	no	RB
cord-264884-ydkigome	286	6	longer	long	RBR
cord-264884-ydkigome	286	7	a	a	DT
cord-264884-ydkigome	286	8	contestable	contestable	JJ
cord-264884-ydkigome	286	9	issue	issue	NN
cord-264884-ydkigome	286	10	in	in	IN
cord-264884-ydkigome	286	11	RNA	RNA	NNP
cord-264884-ydkigome	286	12	virus	virus	NN
cord-264884-ydkigome	286	13	evolution	evolution	NN
cord-264884-ydkigome	286	14	(	(	-LRB-
cord-264884-ydkigome	286	15	see	see	VB
cord-264884-ydkigome	286	16	below	below	RB
cord-264884-ydkigome	286	17	)	)	-RRB-
cord-264884-ydkigome	286	18	.	.	.
cord-264884-ydkigome	287	1	I	-PRON-	PRP
cord-264884-ydkigome	287	2	expect	expect	VBP
cord-264884-ydkigome	287	3	that	that	IN
cord-264884-ydkigome	287	4	many	many	JJ
cord-264884-ydkigome	287	5	classical	classical	JJ
cord-264884-ydkigome	287	6	evolutionary	evolutionary	JJ
cord-264884-ydkigome	287	7	biologists	biologist	NNS
cord-264884-ydkigome	287	8	might	may	MD
cord-264884-ydkigome	287	9	interpret	interpret	VB
cord-264884-ydkigome	287	10	this	this	DT
cord-264884-ydkigome	287	11	as	as	IN
cord-264884-ydkigome	287	12	evidence	evidence	NN
cord-264884-ydkigome	287	13	that	that	IN
cord-264884-ydkigome	287	14	viruses	virus	NNS
cord-264884-ydkigome	287	15	really	really	RB
cord-264884-ydkigome	287	16	are	be	VBP
cord-264884-ydkigome	287	17	an	an	DT
cord-264884-ydkigome	287	18	oddity	oddity	NN
cord-264884-ydkigome	287	19	in	in	IN
cord-264884-ydkigome	287	20	this	this	DT
cord-264884-ydkigome	287	21	feature	feature	NN
cord-264884-ydkigome	287	22	and	and	CC
cord-264884-ydkigome	287	23	are	be	VBP
cord-264884-ydkigome	287	24	not	not	RB
cord-264884-ydkigome	287	25	representative	representative	JJ
cord-264884-ydkigome	287	26	of	of	IN
cord-264884-ydkigome	287	27	broader	broad	JJR
cord-264884-ydkigome	287	28	processes	process	NNS
cord-264884-ydkigome	287	29	of	of	IN
cord-264884-ydkigome	287	30	evolutionary	evolutionary	JJ
cord-264884-ydkigome	287	31	biology	biology	NN
cord-264884-ydkigome	287	32	.	.	.
cord-264884-ydkigome	288	1	Furthermore	furthermore	RB
cord-264884-ydkigome	288	2	,	,	,
cord-264884-ydkigome	288	3	viral	viral	RB
cord-264884-ydkigome	288	4	-	-	HYPH
cord-264884-ydkigome	288	5	based	base	VBN
cord-264884-ydkigome	288	6	group	group	NN
cord-264884-ydkigome	288	7	selection	selection	NN
cord-264884-ydkigome	288	8	may	may	MD
cord-264884-ydkigome	288	9	not	not	RB
cord-264884-ydkigome	288	10	be	be	VB
cord-264884-ydkigome	288	11	limited	limit	VBN
cord-264884-ydkigome	288	12	to	to	IN
cord-264884-ydkigome	288	13	quasispecies	quasispecie	NNS
cord-264884-ydkigome	288	14	-	-	HYPH
cord-264884-ydkigome	288	15	based	base	VBN
cord-264884-ydkigome	288	16	evolution	evolution	NN
cord-264884-ydkigome	288	17	.	.	.
cord-264884-ydkigome	289	1	As	as	IN
cord-264884-ydkigome	289	2	presented	present	VBN
cord-264884-ydkigome	289	3	below	below	RB
cord-264884-ydkigome	289	4	,	,	,
cord-264884-ydkigome	289	5	persistent	persistent	JJ
cord-264884-ydkigome	289	6	viral	viral	JJ
cord-264884-ydkigome	289	7	infections	infection	NNS
cord-264884-ydkigome	289	8	may	may	MD
cord-264884-ydkigome	289	9	also	also	RB
cord-264884-ydkigome	289	10	provide	provide	VB
cord-264884-ydkigome	289	11	population	population	NN
cord-264884-ydkigome	289	12	-	-	HYPH
cord-264884-ydkigome	289	13	based	base	VBN
cord-264884-ydkigome	289	14	selective	selective	JJ
cord-264884-ydkigome	289	15	advantage	advantage	NN
cord-264884-ydkigome	289	16	(	(	-LRB-
cord-264884-ydkigome	289	17	see	see	VB
cord-264884-ydkigome	289	18	below	below	RB
cord-264884-ydkigome	289	19	for	for	IN
cord-264884-ydkigome	289	20	the	the	DT
cord-264884-ydkigome	289	21	P1	P1	NNP
cord-264884-ydkigome	289	22	and	and	CC
cord-264884-ydkigome	289	23	mouse	mouse	NN
cord-264884-ydkigome	289	24	hepatitis	hepatitis	NN
cord-264884-ydkigome	289	25	virus	virus	NN
cord-264884-ydkigome	289	26	(	(	-LRB-
cord-264884-ydkigome	289	27	MHV	MHV	NNP
cord-264884-ydkigome	289	28	)	)	-RRB-
cord-264884-ydkigome	289	29	persistence	persistence	NN
cord-264884-ydkigome	289	30	exemplars	exemplar	NNS
cord-264884-ydkigome	289	31	;	;	:
cord-264884-ydkigome	289	32	Villarreal	Villarreal	NNP
cord-264884-ydkigome	289	33	,	,	,
cord-264884-ydkigome	289	34	2006	2006	CD
cord-264884-ydkigome	289	35	Villarreal	Villarreal	NNP
cord-264884-ydkigome	289	36	,	,	,
cord-264884-ydkigome	289	37	,	,	,
cord-264884-ydkigome	289	38	2007	2007	CD
cord-264884-ydkigome	289	39	.	.	.
cord-264884-ydkigome	290	1	Since	since	IN
cord-264884-ydkigome	290	2	viruses	virus	NNS
cord-264884-ydkigome	290	3	are	be	VBP
cord-264884-ydkigome	290	4	ancient	ancient	JJ
cord-264884-ydkigome	290	5	,	,	,
cord-264884-ydkigome	290	6	numerically	numerically	RB
cord-264884-ydkigome	290	7	dominant	dominant	JJ
cord-264884-ydkigome	290	8	,	,	,
cord-264884-ydkigome	290	9	and	and	CC
cord-264884-ydkigome	290	10	the	the	DT
cord-264884-ydkigome	290	11	most	most	RBS
cord-264884-ydkigome	290	12	diverse	diverse	JJ
cord-264884-ydkigome	290	13	biological	biological	JJ
cord-264884-ydkigome	290	14	entities	entity	NNS
cord-264884-ydkigome	290	15	on	on	IN
cord-264884-ydkigome	290	16	Earth	Earth	NNP
cord-264884-ydkigome	290	17	,	,	,
cord-264884-ydkigome	290	18	no	no	DT
cord-264884-ydkigome	290	19	life	life	NN
cord-264884-ydkigome	290	20	form	form	NN
cord-264884-ydkigome	290	21	can	can	MD
cord-264884-ydkigome	290	22	escape	escape	VB
cord-264884-ydkigome	290	23	exposure	exposure	NN
cord-264884-ydkigome	290	24	to	to	IN
cord-264884-ydkigome	290	25	them	-PRON-	PRP
cord-264884-ydkigome	290	26	.	.	.
cord-264884-ydkigome	291	1	All	all	DT
cord-264884-ydkigome	291	2	extant	extant	JJ
cord-264884-ydkigome	291	3	life	life	NN
cord-264884-ydkigome	291	4	forms	form	NNS
cord-264884-ydkigome	291	5	have	have	VBP
cord-264884-ydkigome	291	6	evolved	evolve	VBN
cord-264884-ydkigome	291	7	in	in	IN
cord-264884-ydkigome	291	8	a	a	DT
cord-264884-ydkigome	291	9	viral	viral	JJ
cord-264884-ydkigome	291	10	habitat	habitat	NN
cord-264884-ydkigome	291	11	.	.	.
cord-264884-ydkigome	292	1	Thus	thus	RB
cord-264884-ydkigome	292	2	we	-PRON-	PRP
cord-264884-ydkigome	292	3	should	should	MD
cord-264884-ydkigome	292	4	expect	expect	VB
cord-264884-ydkigome	292	5	that	that	IN
cord-264884-ydkigome	292	6	the	the	DT
cord-264884-ydkigome	292	7	viral	viral	JJ
cord-264884-ydkigome	292	8	footprints	footprint	NNS
cord-264884-ydkigome	292	9	(	(	-LRB-
cord-264884-ydkigome	292	10	including	include	VBG
cord-264884-ydkigome	292	11	defectives	defective	NNS
cord-264884-ydkigome	292	12	)	)	-RRB-
cord-264884-ydkigome	292	13	that	that	IN
cord-264884-ydkigome	292	14	we	-PRON-	PRP
cord-264884-ydkigome	292	15	now	now	RB
cord-264884-ydkigome	292	16	fi	fi	VBP
cord-264884-ydkigome	292	17	nd	nd	NNP
cord-264884-ydkigome	292	18	in	in	IN
cord-264884-ydkigome	292	19	all	all	DT
cord-264884-ydkigome	292	20	genomes	genome	NNS
cord-264884-ydkigome	292	21	have	have	VBP
cord-264884-ydkigome	292	22	likely	likely	RB
cord-264884-ydkigome	292	23	played	play	VBN
cord-264884-ydkigome	292	24	an	an	DT
cord-264884-ydkigome	292	25	active	active	JJ
cord-264884-ydkigome	292	26	role	role	NN
cord-264884-ydkigome	292	27	in	in	IN
cord-264884-ydkigome	292	28	their	-PRON-	PRP$
cord-264884-ydkigome	292	29	evolution	evolution	NN
cord-264884-ydkigome	292	30	;	;	:
cord-264884-ydkigome	292	31	a	a	DT
cord-264884-ydkigome	292	32	role	role	NN
cord-264884-ydkigome	292	33	,	,	,
cord-264884-ydkigome	292	34	I	-PRON-	PRP
cord-264884-ydkigome	292	35	would	would	MD
cord-264884-ydkigome	292	36	argue	argue	VB
cord-264884-ydkigome	292	37	,	,	,
cord-264884-ydkigome	292	38	that	that	DT
cord-264884-ydkigome	292	39	is	be	VBZ
cord-264884-ydkigome	292	40	fundamental	fundamental	JJ
cord-264884-ydkigome	292	41	,	,	,
cord-264884-ydkigome	292	42	dynamic	dynamic	JJ
cord-264884-ydkigome	292	43	,	,	,
cord-264884-ydkigome	292	44	and	and	CC
cord-264884-ydkigome	292	45	unending	unending	NN
cord-264884-ydkigome	292	46	.	.	.
cord-264884-ydkigome	293	1	If	if	IN
cord-264884-ydkigome	293	2	we	-PRON-	PRP
cord-264884-ydkigome	293	3	can	can	MD
cord-264884-ydkigome	293	4	accept	accept	VB
cord-264884-ydkigome	293	5	this	this	DT
cord-264884-ydkigome	293	6	assertion	assertion	NN
cord-264884-ydkigome	293	7	,	,	,
cord-264884-ydkigome	293	8	we	-PRON-	PRP
cord-264884-ydkigome	293	9	may	may	MD
cord-264884-ydkigome	293	10	start	start	VB
cord-264884-ydkigome	293	11	to	to	TO
cord-264884-ydkigome	293	12	see	see	VB
cord-264884-ydkigome	293	13	and	and	CC
cord-264884-ydkigome	293	14	appreciate	appreciate	VB
cord-264884-ydkigome	293	15	the	the	DT
cord-264884-ydkigome	293	16	vast	vast	JJ
cord-264884-ydkigome	293	17	evolutionary	evolutionary	JJ
cord-264884-ydkigome	293	18	power	power	NN
cord-264884-ydkigome	293	19	that	that	WDT
cord-264884-ydkigome	293	20	viruses	virus	NNS
cord-264884-ydkigome	293	21	can	can	MD
cord-264884-ydkigome	293	22	bring	bring	VB
cord-264884-ydkigome	293	23	to	to	TO
cord-264884-ydkigome	293	24	bear	bear	VB
cord-264884-ydkigome	293	25	onto	onto	IN
cord-264884-ydkigome	293	26	host	host	NN
cord-264884-ydkigome	293	27	evolution	evolution	NN
cord-264884-ydkigome	293	28	.	.	.
cord-264884-ydkigome	294	1	We	-PRON-	PRP
cord-264884-ydkigome	294	2	can	can	MD
cord-264884-ydkigome	294	3	start	start	VB
cord-264884-ydkigome	294	4	to	to	TO
cord-264884-ydkigome	294	5	attain	attain	VB
cord-264884-ydkigome	294	6	a	a	DT
cord-264884-ydkigome	294	7	global	global	JJ
cord-264884-ydkigome	294	8	perspective	perspective	NN
cord-264884-ydkigome	294	9	and	and	CC
cord-264884-ydkigome	294	10	appreciation	appreciation	NN
cord-264884-ydkigome	294	11	for	for	IN
cord-264884-ydkigome	294	12	their	-PRON-	PRP$
cord-264884-ydkigome	294	13	ability	ability	NN
cord-264884-ydkigome	294	14	to	to	TO
cord-264884-ydkigome	294	15	assemble	assemble	VB
cord-264884-ydkigome	294	16	genetic	genetic	JJ
cord-264884-ydkigome	294	17	function	function	NN
cord-264884-ydkigome	294	18	from	from	IN
cord-264884-ydkigome	294	19	enormous	enormous	JJ
cord-264884-ydkigome	294	20	,	,	,
cord-264884-ydkigome	294	21	complex	complex	JJ
cord-264884-ydkigome	294	22	mixtures	mixture	NNS
cord-264884-ydkigome	294	23	of	of	IN
cord-264884-ydkigome	294	24	genomes	genome	NNS
cord-264884-ydkigome	294	25	,	,	,
cord-264884-ydkigome	294	26	and	and	CC
cord-264884-ydkigome	294	27	select	select	JJ
cord-264884-ydkigome	294	28	gene	gene	NN
cord-264884-ydkigome	294	29	sets	set	NNS
cord-264884-ydkigome	294	30	needed	need	VBN
cord-264884-ydkigome	294	31	to	to	TO
cord-264884-ydkigome	294	32	solve	solve	VB
cord-264884-ydkigome	294	33	multivariant	multivariant	JJ
cord-264884-ydkigome	294	34	,	,	,
cord-264884-ydkigome	294	35	temporally	temporally	RB
cord-264884-ydkigome	294	36	dynamic	dynamic	JJ
cord-264884-ydkigome	294	37	evolutionary	evolutionary	JJ
cord-264884-ydkigome	294	38	problems	problem	NNS
cord-264884-ydkigome	294	39	.	.	.
cord-264884-ydkigome	295	1	We	-PRON-	PRP
cord-264884-ydkigome	295	2	can	can	MD
cord-264884-ydkigome	295	3	then	then	RB
cord-264884-ydkigome	295	4	seek	seek	VB
cord-264884-ydkigome	295	5	evidence	evidence	NN
cord-264884-ydkigome	295	6	for	for	IN
cord-264884-ydkigome	295	7	the	the	DT
cord-264884-ydkigome	295	8	role	role	NN
cord-264884-ydkigome	295	9	of	of	IN
cord-264884-ydkigome	295	10	viral	viral	JJ
cord-264884-ydkigome	295	11	elements	element	NNS
cord-264884-ydkigome	295	12	in	in	IN
cord-264884-ydkigome	295	13	fundamental	fundamental	JJ
cord-264884-ydkigome	295	14	host	host	NN
cord-264884-ydkigome	295	15	innovation	innovation	NN
cord-264884-ydkigome	295	16	and	and	CC
cord-264884-ydkigome	295	17	be	be	VB
cord-264884-ydkigome	295	18	open	open	JJ
cord-264884-ydkigome	295	19	to	to	IN
cord-264884-ydkigome	295	20	evaluating	evaluate	VBG
cord-264884-ydkigome	295	21	the	the	DT
cord-264884-ydkigome	295	22	occurrence	occurrence	NN
cord-264884-ydkigome	295	23	of	of	IN
cord-264884-ydkigome	295	24	viral	viral	JJ
cord-264884-ydkigome	295	25	entities	entity	NNS
cord-264884-ydkigome	295	26	from	from	IN
cord-264884-ydkigome	295	27	a	a	DT
cord-264884-ydkigome	295	28	constructive	constructive	JJ
cord-264884-ydkigome	295	29	perspective	perspective	NN
cord-264884-ydkigome	295	30	and	and	CC
cord-264884-ydkigome	295	31	not	not	RB
cord-264884-ydkigome	295	32	instinctively	instinctively	RB
cord-264884-ydkigome	295	33	dismiss	dismiss	VB
cord-264884-ydkigome	295	34	such	such	JJ
cord-264884-ydkigome	295	35	observations	observation	NNS
cord-264884-ydkigome	295	36	as	as	IN
cord-264884-ydkigome	295	37	due	due	IN
cord-264884-ydkigome	295	38	to	to	IN
cord-264884-ydkigome	295	39	coincidence	coincidence	NN
cord-264884-ydkigome	295	40	,	,	,
cord-264884-ydkigome	295	41	"	"	``
cord-264884-ydkigome	295	42	junk	junk	NN
cord-264884-ydkigome	295	43	,	,	,
cord-264884-ydkigome	295	44	"	"	''
cord-264884-ydkigome	295	45	or	or	CC
cord-264884-ydkigome	295	46	selfi	selfi	NNP
cord-264884-ydkigome	295	47	sh	sh	NNP
cord-264884-ydkigome	295	48	DNA	DNA	NNP
cord-264884-ydkigome	295	49	.	.	.
cord-264884-ydkigome	296	1	The	the	DT
cord-264884-ydkigome	296	2	advantage	advantage	NN
cord-264884-ydkigome	296	3	of	of	IN
cord-264884-ydkigome	296	4	such	such	PDT
cord-264884-ydkigome	296	5	a	a	DT
cord-264884-ydkigome	296	6	perspective	perspective	NN
cord-264884-ydkigome	296	7	is	be	VBZ
cord-264884-ydkigome	296	8	that	that	IN
cord-264884-ydkigome	296	9	it	-PRON-	PRP
cord-264884-ydkigome	296	10	will	will	MD
cord-264884-ydkigome	296	11	promote	promote	VB
cord-264884-ydkigome	296	12	the	the	DT
cord-264884-ydkigome	296	13	specifi	specifi	NNP
cord-264884-ydkigome	296	14	c	c	NNP
cord-264884-ydkigome	296	15	experimental	experimental	JJ
cord-264884-ydkigome	296	16	evaluations	evaluation	NNS
cord-264884-ydkigome	296	17	that	that	WDT
cord-264884-ydkigome	296	18	can	can	MD
cord-264884-ydkigome	296	19	better	well	RBR
cord-264884-ydkigome	296	20	assess	assess	VB
cord-264884-ydkigome	296	21	any	any	DT
cord-264884-ydkigome	296	22	constructive	constructive	JJ
cord-264884-ydkigome	296	23	role	role	NN
cord-264884-ydkigome	296	24	genetic	genetic	JJ
cord-264884-ydkigome	296	25	parasites	parasite	NNS
cord-264884-ydkigome	296	26	might	may	MD
cord-264884-ydkigome	296	27	have	have	VB
cord-264884-ydkigome	296	28	played	play	VBN
cord-264884-ydkigome	296	29	in	in	IN
cord-264884-ydkigome	296	30	host	host	NN
cord-264884-ydkigome	296	31	evolution	evolution	NN
cord-264884-ydkigome	296	32	.	.	.
cord-264884-ydkigome	297	1	For	for	IN
cord-264884-ydkigome	297	2	example	example	NN
cord-264884-ydkigome	297	3	,	,	,
cord-264884-ydkigome	297	4	there	there	EX
cord-264884-ydkigome	297	5	is	be	VBZ
cord-264884-ydkigome	297	6	much	much	JJ
cord-264884-ydkigome	297	7	reason	reason	NN
cord-264884-ydkigome	297	8	to	to	TO
cord-264884-ydkigome	297	9	think	think	VB
cord-264884-ydkigome	297	10	ERVs	erv	NNS
cord-264884-ydkigome	297	11	have	have	VBP
cord-264884-ydkigome	297	12	played	play	VBN
cord-264884-ydkigome	297	13	an	an	DT
cord-264884-ydkigome	297	14	active	active	JJ
cord-264884-ydkigome	297	15	role	role	NN
cord-264884-ydkigome	297	16	in	in	IN
cord-264884-ydkigome	297	17	human	human	JJ
cord-264884-ydkigome	297	18	evolution	evolution	NN
cord-264884-ydkigome	297	19	(	(	-LRB-
cord-264884-ydkigome	297	20	for	for	IN
cord-264884-ydkigome	297	21	references	reference	NNS
cord-264884-ydkigome	297	22	see	see	VBP
cord-264884-ydkigome	297	23	Ryan	Ryan	NNP
cord-264884-ydkigome	297	24	,	,	,
cord-264884-ydkigome	297	25	2007	2007	CD
cord-264884-ydkigome	297	26	)	)	-RRB-
cord-264884-ydkigome	297	27	.	.	.
cord-264884-ydkigome	298	1	The	the	DT
cord-264884-ydkigome	298	2	quasispecies	quasispecie	NNS
cord-264884-ydkigome	298	3	concept	concept	NN
cord-264884-ydkigome	298	4	has	have	VBZ
cord-264884-ydkigome	298	5	provided	provide	VBN
cord-264884-ydkigome	298	6	the	the	DT
cord-264884-ydkigome	298	7	foundation	foundation	NN
cord-264884-ydkigome	298	8	for	for	IN
cord-264884-ydkigome	298	9	us	-PRON-	PRP
cord-264884-ydkigome	298	10	to	to	TO
cord-264884-ydkigome	298	11	understand	understand	VB
cord-264884-ydkigome	298	12	virus	virus	NN
cord-264884-ydkigome	298	13	evolution	evolution	NN
cord-264884-ydkigome	298	14	and	and	CC
cord-264884-ydkigome	298	15	informed	inform	VBD
cord-264884-ydkigome	298	16	us	-PRON-	PRP
cord-264884-ydkigome	298	17	of	of	IN
cord-264884-ydkigome	298	18	the	the	DT
cord-264884-ydkigome	298	19	evolutionary	evolutionary	JJ
cord-264884-ydkigome	298	20	power	power	NN
cord-264884-ydkigome	298	21	viruses	virus	NNS
cord-264884-ydkigome	298	22	possess	possess	VBP
cord-264884-ydkigome	298	23	.	.	.
cord-264884-ydkigome	299	1	If	if	IN
cord-264884-ydkigome	299	2	that	that	DT
cord-264884-ydkigome	299	3	power	power	NN
cord-264884-ydkigome	299	4	also	also	RB
cord-264884-ydkigome	299	5	links	link	VBZ
cord-264884-ydkigome	299	6	to	to	TO
cord-264884-ydkigome	299	7	host	host	VB
cord-264884-ydkigome	299	8	evolution	evolution	NN
cord-264884-ydkigome	299	9	,	,	,
cord-264884-ydkigome	299	10	then	then	RB
cord-264884-ydkigome	299	11	the	the	DT
cord-264884-ydkigome	299	12	tree	tree	NN
cord-264884-ydkigome	299	13	of	of	IN
cord-264884-ydkigome	299	14	life	life	NN
cord-264884-ydkigome	299	15	becomes	become	VBZ
cord-264884-ydkigome	299	16	enriched	enrich	VBN
cord-264884-ydkigome	299	17	by	by	IN
cord-264884-ydkigome	299	18	virus	virus	NN
cord-264884-ydkigome	299	19	,	,	,
cord-264884-ydkigome	299	20	much	much	RB
cord-264884-ydkigome	299	21	larger	large	JJR
cord-264884-ydkigome	299	22	and	and	CC
cord-264884-ydkigome	299	23	more	more	RBR
cord-264884-ydkigome	299	24	dynamic	dynamic	JJ
cord-264884-ydkigome	299	25	.	.	.
cord-264884-ydkigome	300	1	The	the	DT
cord-264884-ydkigome	300	2	recent	recent	JJ
cord-264884-ydkigome	300	3	experimental	experimental	JJ
cord-264884-ydkigome	300	4	studies	study	NNS
cord-264884-ydkigome	300	5	from	from	IN
cord-264884-ydkigome	300	6	Andino	Andino	NNP
cord-264884-ydkigome	300	7	and	and	CC
cord-264884-ydkigome	300	8	colleagues	colleague	NNS
cord-264884-ydkigome	300	9	using	use	VBG
cord-264884-ydkigome	300	10	poliovirus	poliovirus	NN
cord-264884-ydkigome	300	11	in	in	IN
cord-264884-ydkigome	300	12	the	the	DT
cord-264884-ydkigome	300	13	mouse	mouse	NN
cord-264884-ydkigome	300	14	model	model	NN
cord-264884-ydkigome	300	15	should	should	MD
cord-264884-ydkigome	300	16	,	,	,
cord-264884-ydkigome	300	17	in	in	IN
cord-264884-ydkigome	300	18	my	-PRON-	PRP$
cord-264884-ydkigome	300	19	judgment	judgment	NN
cord-264884-ydkigome	300	20	,	,	,
cord-264884-ydkigome	300	21	provide	provide	VB
cord-264884-ydkigome	300	22	the	the	DT
cord-264884-ydkigome	300	23	keystone	keystone	NNP
cord-264884-ydkigome	300	24	exemplar	exemplar	NN
cord-264884-ydkigome	300	25	regarding	regard	VBG
cord-264884-ydkigome	300	26	the	the	DT
cord-264884-ydkigome	300	27	in	in	IN
cord-264884-ydkigome	300	28	vivo	vivo	NN
cord-264884-ydkigome	300	29	fi	fi	NN
cord-264884-ydkigome	300	30	tness	tness	NN
cord-264884-ydkigome	300	31	of	of	IN
cord-264884-ydkigome	300	32	quasispecies	quasispecie	NNS
cord-264884-ydkigome	300	33	(	(	-LRB-
cord-264884-ydkigome	300	34	see	see	VB
cord-264884-ydkigome	300	35	Chapters	Chapters	NNP
cord-264884-ydkigome	300	36	6	6	CD
cord-264884-ydkigome	300	37	and	and	CC
cord-264884-ydkigome	300	38	7	7	CD
cord-264884-ydkigome	300	39	;	;	:
cord-264884-ydkigome	300	40	Vignuzzi	Vignuzzi	NNP
cord-264884-ydkigome	300	41	et	et	NNP
cord-264884-ydkigome	300	42	al	al	NNP
cord-264884-ydkigome	300	43	.	.	NNP
cord-264884-ydkigome	300	44	,	,	,
cord-264884-ydkigome	300	45	2006	2006	CD
cord-264884-ydkigome	300	46	)	)	-RRB-
cord-264884-ydkigome	300	47	.	.	.
cord-264884-ydkigome	301	1	These	these	DT
cord-264884-ydkigome	301	2	studies	study	NNS
cord-264884-ydkigome	301	3	make	make	VBP
cord-264884-ydkigome	301	4	clear	clear	JJ
cord-264884-ydkigome	301	5	the	the	DT
cord-264884-ydkigome	301	6	importance	importance	NN
cord-264884-ydkigome	301	7	of	of	IN
cord-264884-ydkigome	301	8	quasispecies	quasispecie	NNS
cord-264884-ydkigome	301	9	and	and	CC
cord-264884-ydkigome	301	10	error	error	NN
cord-264884-ydkigome	301	11	-	-	HYPH
cord-264884-ydkigome	301	12	prone	prone	JJ
cord-264884-ydkigome	301	13	replication	replication	NN
cord-264884-ydkigome	301	14	.	.	.
cord-264884-ydkigome	302	1	Such	such	JJ
cord-264884-ydkigome	302	2	detailed	detail	VBN
cord-264884-ydkigome	302	3	in	in	IN
cord-264884-ydkigome	302	4	vivo	vivo	NN
cord-264884-ydkigome	302	5	experiments	experiment	NNS
cord-264884-ydkigome	302	6	were	be	VBD
cord-264884-ydkigome	302	7	made	make	VBN
cord-264884-ydkigome	302	8	possible	possible	JJ
cord-264884-ydkigome	302	9	by	by	IN
cord-264884-ydkigome	302	10	a	a	DT
cord-264884-ydkigome	302	11	long	long	JJ
cord-264884-ydkigome	302	12	and	and	CC
cord-264884-ydkigome	302	13	detailed	detailed	JJ
cord-264884-ydkigome	302	14	history	history	NN
cord-264884-ydkigome	302	15	of	of	IN
cord-264884-ydkigome	302	16	poliovirus	poliovirus	NN
cord-264884-ydkigome	302	17	studies	study	NNS
cord-264884-ydkigome	302	18	that	that	WDT
cord-264884-ydkigome	302	19	has	have	VBZ
cord-264884-ydkigome	302	20	identifi	identifi	VBN
cord-264884-ydkigome	302	21	ed	ed	NNP
cord-264884-ydkigome	302	22	the	the	DT
cord-264884-ydkigome	302	23	nature	nature	NN
cord-264884-ydkigome	302	24	of	of	IN
cord-264884-ydkigome	302	25	RNA	RNA	NNP
cord-264884-ydkigome	302	26	polymerase	polymerase	NN
cord-264884-ydkigome	302	27	fi	fi	NN
cord-264884-ydkigome	302	28	delity	delity	NNP
cord-264884-ydkigome	302	29	as	as	RB
cord-264884-ydkigome	302	30	well	well	RB
cord-264884-ydkigome	302	31	as	as	IN
cord-264884-ydkigome	302	32	developed	develop	VBN
cord-264884-ydkigome	302	33	mouse	mouse	NN
cord-264884-ydkigome	302	34	models	model	NNS
cord-264884-ydkigome	302	35	for	for	IN
cord-264884-ydkigome	302	36	the	the	DT
cord-264884-ydkigome	302	37	study	study	NN
cord-264884-ydkigome	302	38	of	of	IN
cord-264884-ydkigome	302	39	pathogenesis	pathogenesis	NN
cord-264884-ydkigome	302	40	.	.	.
cord-264884-ydkigome	303	1	Few	few	JJ
cord-264884-ydkigome	303	2	other	other	JJ
cord-264884-ydkigome	303	3	virus	virus	NN
cord-264884-ydkigome	303	4	-	-	HYPH
cord-264884-ydkigome	303	5	host	host	NN
cord-264884-ydkigome	303	6	systems	system	NNS
cord-264884-ydkigome	303	7	could	could	MD
cord-264884-ydkigome	303	8	have	have	VB
cord-264884-ydkigome	303	9	provided	provide	VBN
cord-264884-ydkigome	303	10	such	such	JJ
cord-264884-ydkigome	303	11	potential	potential	NN
cord-264884-ydkigome	303	12	for	for	IN
cord-264884-ydkigome	303	13	high	high	JJ
cord-264884-ydkigome	303	14	resolution	resolution	NN
cord-264884-ydkigome	303	15	.	.	.
cord-264884-ydkigome	304	1	These	these	DT
cord-264884-ydkigome	304	2	results	result	NNS
cord-264884-ydkigome	304	3	also	also	RB
cord-264884-ydkigome	304	4	provide	provide	VBP
cord-264884-ydkigome	304	5	the	the	DT
cord-264884-ydkigome	304	6	experimental	experimental	JJ
cord-264884-ydkigome	304	7	observations	observation	NNS
cord-264884-ydkigome	304	8	that	that	WDT
cord-264884-ydkigome	304	9	distinguish	distinguish	VBP
cord-264884-ydkigome	304	10	quasispecies	quasispecie	NNS
cord-264884-ydkigome	304	11	-	-	HYPH
cord-264884-ydkigome	304	12	based	base	VBN
cord-264884-ydkigome	304	13	evolution	evolution	NN
cord-264884-ydkigome	304	14	from	from	IN
cord-264884-ydkigome	304	15	the	the	DT
cord-264884-ydkigome	304	16	classical	classical	JJ
cord-264884-ydkigome	304	17	Fisher	Fisher	NNP
cord-264884-ydkigome	304	18	-	-	HYPH
cord-264884-ydkigome	304	19	based	base	VBN
cord-264884-ydkigome	304	20	population	population	NN
cord-264884-ydkigome	304	21	genetics	genetics	NN
cord-264884-ydkigome	304	22	.	.	.
cord-264884-ydkigome	305	1	The	the	DT
cord-264884-ydkigome	305	2	general	general	JJ
cord-264884-ydkigome	305	3	importance	importance	NN
cord-264884-ydkigome	305	4	of	of	IN
cord-264884-ydkigome	305	5	this	this	DT
cord-264884-ydkigome	305	6	story	story	NN
cord-264884-ydkigome	305	7	for	for	IN
cord-264884-ydkigome	305	8	understanding	understand	VBG
cord-264884-ydkigome	305	9	virus	virus	NN
cord-264884-ydkigome	305	10	evolution	evolution	NN
cord-264884-ydkigome	305	11	thus	thus	RB
cord-264884-ydkigome	305	12	deserves	deserve	VBZ
cord-264884-ydkigome	305	13	special	special	JJ
cord-264884-ydkigome	305	14	emphasis	emphasis	NN
cord-264884-ydkigome	305	15	.	.	.
cord-264884-ydkigome	306	1	The	the	DT
cord-264884-ydkigome	306	2	very	very	JJ
cord-264884-ydkigome	306	3	origins	origin	NNS
cord-264884-ydkigome	306	4	of	of	IN
cord-264884-ydkigome	306	5	modern	modern	JJ
cord-264884-ydkigome	306	6	animal	animal	NN
cord-264884-ydkigome	306	7	virology	virology	NN
cord-264884-ydkigome	306	8	stem	stem	NN
cord-264884-ydkigome	306	9	from	from	IN
cord-264884-ydkigome	306	10	poliovirus	poliovirus	NN
cord-264884-ydkigome	306	11	studies	study	NNS
cord-264884-ydkigome	306	12	with	with	IN
cord-264884-ydkigome	306	13	the	the	DT
cord-264884-ydkigome	306	14	need	need	NN
cord-264884-ydkigome	306	15	to	to	TO
cord-264884-ydkigome	306	16	develop	develop	VB
cord-264884-ydkigome	306	17	in	in	IN
cord-264884-ydkigome	306	18	vitro	vitro	FW
cord-264884-ydkigome	306	19	cell	cell	NN
cord-264884-ydkigome	306	20	culture	culture	NN
cord-264884-ydkigome	306	21	technology	technology	NN
cord-264884-ydkigome	306	22	in	in	IN
cord-264884-ydkigome	306	23	order	order	NN
cord-264884-ydkigome	306	24	to	to	TO
cord-264884-ydkigome	306	25	grow	grow	VB
cord-264884-ydkigome	306	26	and	and	CC
cord-264884-ydkigome	306	27	evaluate	evaluate	VB
cord-264884-ydkigome	306	28	poliovirus	poliovirus	NN
cord-264884-ydkigome	306	29	and	and	CC
cord-264884-ydkigome	306	30	generate	generate	VB
cord-264884-ydkigome	306	31	variants	variant	NNS
cord-264884-ydkigome	306	32	.	.	.
cord-264884-ydkigome	307	1	The	the	DT
cord-264884-ydkigome	307	2	live	live	JJ
cord-264884-ydkigome	307	3	poliovirus	poliovirus	NN
cord-264884-ydkigome	307	4	vaccine	vaccine	NN
cord-264884-ydkigome	307	5	is	be	VBZ
cord-264884-ydkigome	307	6	of	of	IN
cord-264884-ydkigome	307	7	special	special	JJ
cord-264884-ydkigome	307	8	interest	interest	NN
cord-264884-ydkigome	307	9	with	with	IN
cord-264884-ydkigome	307	10	regards	regard	NNS
cord-264884-ydkigome	307	11	to	to	IN
cord-264884-ydkigome	307	12	virus	virus	NN
cord-264884-ydkigome	307	13	evolution	evolution	NN
cord-264884-ydkigome	307	14	and	and	CC
cord-264884-ydkigome	307	15	adaptability	adaptability	NN
cord-264884-ydkigome	307	16	.	.	.
cord-264884-ydkigome	308	1	The	the	DT
cord-264884-ydkigome	308	2	"	"	``
cord-264884-ydkigome	308	3	live	live	JJ
cord-264884-ydkigome	308	4	"	"	''
cord-264884-ydkigome	308	5	oral	oral	JJ
cord-264884-ydkigome	308	6	Sabin	Sabin	NNP
cord-264884-ydkigome	308	7	vaccine	vaccine	NN
cord-264884-ydkigome	308	8	can	can	MD
cord-264884-ydkigome	308	9	be	be	VB
cord-264884-ydkigome	308	10	considered	consider	VBN
cord-264884-ydkigome	308	11	to	to	TO
cord-264884-ydkigome	308	12	have	have	VB
cord-264884-ydkigome	308	13	been	be	VBN
cord-264884-ydkigome	308	14	a	a	DT
cord-264884-ydkigome	308	15	miracle	miracle	NN
cord-264884-ydkigome	308	16	of	of	IN
cord-264884-ydkigome	308	17	the	the	DT
cord-264884-ydkigome	308	18	practical	practical	JJ
cord-264884-ydkigome	308	19	approach	approach	NN
cord-264884-ydkigome	308	20	to	to	IN
cord-264884-ydkigome	308	21	virology	virology	NN
cord-264884-ydkigome	308	22	developed	develop	VBN
cord-264884-ydkigome	308	23	in	in	IN
cord-264884-ydkigome	308	24	the	the	DT
cord-264884-ydkigome	308	25	1950s	1950	NNS
cord-264884-ydkigome	308	26	(	(	-LRB-
cord-264884-ydkigome	308	27	Horaud	Horaud	NNP
cord-264884-ydkigome	308	28	,	,	,
cord-264884-ydkigome	308	29	1993	1993	CD
cord-264884-ydkigome	308	30	)	)	-RRB-
cord-264884-ydkigome	308	31	in	in	IN
cord-264884-ydkigome	308	32	that	that	IN
cord-264884-ydkigome	308	33	it	-PRON-	PRP
cord-264884-ydkigome	308	34	was	be	VBD
cord-264884-ydkigome	308	35	used	use	VBN
cord-264884-ydkigome	308	36	well	well	RB
cord-264884-ydkigome	308	37	before	before	IN
cord-264884-ydkigome	308	38	our	-PRON-	PRP$
cord-264884-ydkigome	308	39	understanding	understanding	NN
cord-264884-ydkigome	308	40	of	of	IN
cord-264884-ydkigome	308	41	the	the	DT
cord-264884-ydkigome	308	42	relevant	relevant	JJ
cord-264884-ydkigome	308	43	evolutionary	evolutionary	JJ
cord-264884-ydkigome	308	44	theory	theory	NN
cord-264884-ydkigome	308	45	.	.	.
cord-264884-ydkigome	309	1	The	the	DT
cord-264884-ydkigome	309	2	Sabin	Sabin	NNP
cord-264884-ydkigome	309	3	vaccine	vaccine	NN
cord-264884-ydkigome	309	4	strain	strain	NN
cord-264884-ydkigome	309	5	was	be	VBD
cord-264884-ydkigome	309	6	the	the	DT
cord-264884-ydkigome	309	7	result	result	NN
cord-264884-ydkigome	309	8	of	of	IN
cord-264884-ydkigome	309	9	rodentadapted	rodentadapted	JJ
cord-264884-ydkigome	309	10	virus	virus	NN
cord-264884-ydkigome	309	11	and	and	CC
cord-264884-ydkigome	309	12	differs	differ	VBZ
cord-264884-ydkigome	309	13	from	from	IN
cord-264884-ydkigome	309	14	the	the	DT
cord-264884-ydkigome	309	15	neurovirulent	neurovirulent	NN
cord-264884-ydkigome	309	16	Mahoney	Mahoney	NNP
cord-264884-ydkigome	309	17	strain	strain	VBP
cord-264884-ydkigome	309	18	by	by	IN
cord-264884-ydkigome	309	19	56	56	CD
cord-264884-ydkigome	309	20	point	point	NN
cord-264884-ydkigome	309	21	mutations	mutation	NNS
cord-264884-ydkigome	309	22	(	(	-LRB-
cord-264884-ydkigome	309	23	in	in	IN
cord-264884-ydkigome	309	24	the	the	DT
cord-264884-ydkigome	309	25	consensus	consensus	NN
cord-264884-ydkigome	309	26	sequence	sequence	NN
cord-264884-ydkigome	309	27	)	)	-RRB-
cord-264884-ydkigome	309	28	,	,	,
cord-264884-ydkigome	309	29	although	although	IN
cord-264884-ydkigome	309	30	only	only	RB
cord-264884-ydkigome	309	31	a	a	DT
cord-264884-ydkigome	309	32	small	small	JJ
cord-264884-ydkigome	309	33	number	number	NN
cord-264884-ydkigome	309	34	of	of	IN
cord-264884-ydkigome	309	35	these	these	DT
cord-264884-ydkigome	309	36	mutations	mutation	NNS
cord-264884-ydkigome	309	37	were	be	VBD
cord-264884-ydkigome	309	38	needed	need	VBN
cord-264884-ydkigome	309	39	for	for	IN
cord-264884-ydkigome	309	40	neurovirulence	neurovirulence	NNP
cord-264884-ydkigome	310	1	(	(	-LRB-
cord-264884-ydkigome	310	2	Christodoulou	Christodoulou	NNP
cord-264884-ydkigome	310	3	et	et	NNP
cord-264884-ydkigome	310	4	al	al	NNP
cord-264884-ydkigome	310	5	.	.	NNP
cord-264884-ydkigome	310	6	,	,	,
cord-264884-ydkigome	310	7	1990	1990	CD
cord-264884-ydkigome	310	8	)	)	-RRB-
cord-264884-ydkigome	310	9	.	.	.
cord-264884-ydkigome	311	1	One	one	CD
cord-264884-ydkigome	311	2	of	of	IN
cord-264884-ydkigome	311	3	the	the	DT
cord-264884-ydkigome	311	4	important	important	JJ
cord-264884-ydkigome	311	5	neurovirulent	neurovirulent	NN
cord-264884-ydkigome	311	6	mutations	mutation	NNS
cord-264884-ydkigome	311	7	was	be	VBD
cord-264884-ydkigome	311	8	within	within	IN
cord-264884-ydkigome	311	9	the	the	DT
cord-264884-ydkigome	311	10	RNA	RNA	NNP
cord-264884-ydkigome	311	11	polymerase	polymerase	NN
cord-264884-ydkigome	311	12	gene	gene	NN
cord-264884-ydkigome	311	13	(	(	-LRB-
cord-264884-ydkigome	311	14	Tardy	Tardy	NNP
cord-264884-ydkigome	311	15	-	-	HYPH
cord-264884-ydkigome	311	16	Panit	Panit	NNP
cord-264884-ydkigome	311	17	et	et	FW
cord-264884-ydkigome	311	18	al	al	NNP
cord-264884-ydkigome	311	19	.	.	NNP
cord-264884-ydkigome	311	20	,	,	,
cord-264884-ydkigome	311	21	1993	1993	CD
cord-264884-ydkigome	311	22	)	)	-RRB-
cord-264884-ydkigome	311	23	.	.	.
cord-264884-ydkigome	312	1	However	however	RB
cord-264884-ydkigome	312	2	,	,	,
cord-264884-ydkigome	312	3	the	the	DT
cord-264884-ydkigome	312	4	signifi	signifi	NNP
cord-264884-ydkigome	312	5	cance	cance	NN
cord-264884-ydkigome	312	6	of	of	IN
cord-264884-ydkigome	312	7	this	this	DT
cord-264884-ydkigome	312	8	observation	observation	NN
cord-264884-ydkigome	312	9	took	take	VBD
cord-264884-ydkigome	312	10	many	many	JJ
cord-264884-ydkigome	312	11	years	year	NNS
cord-264884-ydkigome	312	12	to	to	TO
cord-264884-ydkigome	312	13	unravel	unravel	VB
cord-264884-ydkigome	312	14	and	and	CC
cord-264884-ydkigome	312	15	exploit	exploit	VB
cord-264884-ydkigome	312	16	.	.	.
cord-264884-ydkigome	313	1	In	in	IN
cord-264884-ydkigome	313	2	time	time	NN
cord-264884-ydkigome	313	3	it	-PRON-	PRP
cord-264884-ydkigome	313	4	became	become	VBD
cord-264884-ydkigome	313	5	apparent	apparent	JJ
cord-264884-ydkigome	313	6	that	that	IN
cord-264884-ydkigome	313	7	3Dpol	3Dpol	NNP
cord-264884-ydkigome	313	8	mutants	mutant	NNS
cord-264884-ydkigome	313	9	could	could	MD
cord-264884-ydkigome	313	10	affect	affect	VB
cord-264884-ydkigome	313	11	replication	replication	NN
cord-264884-ydkigome	313	12	fi	fi	NN
cord-264884-ydkigome	313	13	delity	delity	NN
cord-264884-ydkigome	313	14	.	.	.
cord-264884-ydkigome	314	1	One	one	CD
cord-264884-ydkigome	314	2	poliovirus	poliovirus	NN
cord-264884-ydkigome	314	3	point	point	NN
cord-264884-ydkigome	314	4	mutant	mutant	NN
cord-264884-ydkigome	314	5	,	,	,
cord-264884-ydkigome	314	6	3DG64S	3dg64s	CD
cord-264884-ydkigome	314	7	,	,	,
cord-264884-ydkigome	314	8	was	be	VBD
cord-264884-ydkigome	314	9	shown	show	VBN
cord-264884-ydkigome	314	10	to	to	TO
cord-264884-ydkigome	314	11	have	have	VB
cord-264884-ydkigome	314	12	enhanced	enhance	VBN
cord-264884-ydkigome	314	13	highfi	highfi	NNP
cord-264884-ydkigome	314	14	delity	delity	NNP
cord-264884-ydkigome	314	15	replication	replication	NN
cord-264884-ydkigome	314	16	and	and	CC
cord-264884-ydkigome	314	17	that	that	IN
cord-264884-ydkigome	314	18	selective	selective	JJ
cord-264884-ydkigome	314	19	pressure	pressure	NN
cord-264884-ydkigome	314	20	could	could	MD
cord-264884-ydkigome	314	21	be	be	VB
cord-264884-ydkigome	314	22	designed	design	VBN
cord-264884-ydkigome	314	23	to	to	TO
cord-264884-ydkigome	314	24	increase	increase	VB
cord-264884-ydkigome	314	25	fi	fi	NNP
cord-264884-ydkigome	314	26	delity	delity	NN
cord-264884-ydkigome	314	27	in	in	IN
cord-264884-ydkigome	314	28	RNA	RNA	NNP
cord-264884-ydkigome	314	29	polymerase	polymerase	NN
cord-264884-ydkigome	314	30	(	(	-LRB-
cord-264884-ydkigome	314	31	Pfeiffer	Pfeiffer	NNP
cord-264884-ydkigome	314	32	and	and	CC
cord-264884-ydkigome	314	33	Kirkegaard	Kirkegaard	NNP
cord-264884-ydkigome	314	34	,	,	,
cord-264884-ydkigome	314	35	2005	2005	CD
cord-264884-ydkigome	314	36	)	)	-RRB-
cord-264884-ydkigome	314	37	.	.	.
cord-264884-ydkigome	315	1	Another	another	DT
cord-264884-ydkigome	315	2	major	major	JJ
cord-264884-ydkigome	315	3	development	development	NN
cord-264884-ydkigome	315	4	was	be	VBD
cord-264884-ydkigome	315	5	the	the	DT
cord-264884-ydkigome	315	6	molecular	molecular	JJ
cord-264884-ydkigome	315	7	identifi	identifi	NNP
cord-264884-ydkigome	315	8	cation	cation	NNP
cord-264884-ydkigome	315	9	of	of	IN
cord-264884-ydkigome	315	10	the	the	DT
cord-264884-ydkigome	315	11	poliovirus	poliovirus	NN
cord-264884-ydkigome	315	12	receptor	receptor	NN
cord-264884-ydkigome	315	13	and	and	CC
cord-264884-ydkigome	315	14	the	the	DT
cord-264884-ydkigome	315	15	subsequent	subsequent	JJ
cord-264884-ydkigome	315	16	creation	creation	NN
cord-264884-ydkigome	315	17	of	of	IN
cord-264884-ydkigome	315	18	transgenic	transgenic	JJ
cord-264884-ydkigome	315	19	mice	mouse	NNS
cord-264884-ydkigome	315	20	expressing	express	VBG
cord-264884-ydkigome	315	21	this	this	DT
cord-264884-ydkigome	315	22	receptor	receptor	NN
cord-264884-ydkigome	315	23	,	,	,
cord-264884-ydkigome	315	24	making	make	VBG
cord-264884-ydkigome	315	25	them	-PRON-	PRP
cord-264884-ydkigome	315	26	susceptible	susceptible	JJ
cord-264884-ydkigome	315	27	to	to	IN
cord-264884-ydkigome	315	28	poliovirus	poliovirus	NN
cord-264884-ydkigome	315	29	infection	infection	NN
cord-264884-ydkigome	315	30	.	.	.
cord-264884-ydkigome	316	1	One	one	CD
cord-264884-ydkigome	316	2	of	of	IN
cord-264884-ydkigome	316	3	these	these	DT
cord-264884-ydkigome	316	4	transgenic	transgenic	JJ
cord-264884-ydkigome	316	5	lines	line	NNS
cord-264884-ydkigome	316	6	allowed	allow	VBD
cord-264884-ydkigome	316	7	mouse	mouse	NN
cord-264884-ydkigome	316	8	brain	brain	NN
cord-264884-ydkigome	316	9	infections	infection	NNS
cord-264884-ydkigome	316	10	with	with	IN
cord-264884-ydkigome	316	11	neurovirulent	neurovirulent	NN
cord-264884-ydkigome	316	12	versions	version	NNS
cord-264884-ydkigome	316	13	of	of	IN
cord-264884-ydkigome	316	14	poliovirus	poliovirus	NN
cord-264884-ydkigome	316	15	,	,	,
cord-264884-ydkigome	316	16	and	and	CC
cord-264884-ydkigome	316	17	has	have	VBZ
cord-264884-ydkigome	316	18	provided	provide	VBN
cord-264884-ydkigome	316	19	a	a	DT
cord-264884-ydkigome	316	20	very	very	RB
cord-264884-ydkigome	316	21	useful	useful	JJ
cord-264884-ydkigome	316	22	animal	animal	NN
cord-264884-ydkigome	316	23	model	model	NN
cord-264884-ydkigome	316	24	that	that	WDT
cord-264884-ydkigome	316	25	allowed	allow	VBD
cord-264884-ydkigome	316	26	the	the	DT
cord-264884-ydkigome	316	27	evaluation	evaluation	NN
cord-264884-ydkigome	316	28	of	of	IN
cord-264884-ydkigome	316	29	viral	viral	JJ
cord-264884-ydkigome	316	30	fi	fi	NN
cord-264884-ydkigome	316	31	tness	tness	NN
cord-264884-ydkigome	316	32	in	in	IN
cord-264884-ydkigome	316	33	the	the	DT
cord-264884-ydkigome	316	34	context	context	NN
cord-264884-ydkigome	316	35	of	of	IN
cord-264884-ydkigome	316	36	in	in	IN
cord-264884-ydkigome	316	37	vivo	vivo	NN
cord-264884-ydkigome	316	38	pathogenesis	pathogenesis	NN
cord-264884-ydkigome	316	39	.	.	.
cord-264884-ydkigome	317	1	Although	although	IN
cord-264884-ydkigome	317	2	3DG64S	3dg64s	CD
cord-264884-ydkigome	317	3	replicates	replicate	VBZ
cord-264884-ydkigome	317	4	well	well	RB
cord-264884-ydkigome	317	5	in	in	IN
cord-264884-ydkigome	317	6	culture	culture	NN
cord-264884-ydkigome	317	7	(	(	-LRB-
cord-264884-ydkigome	317	8	with	with	IN
cord-264884-ydkigome	317	9	lowered	lowered	JJ
cord-264884-ydkigome	317	10	error	error	NN
cord-264884-ydkigome	317	11	rate	rate	NN
cord-264884-ydkigome	317	12	)	)	-RRB-
cord-264884-ydkigome	317	13	,	,	,
cord-264884-ydkigome	317	14	it	-PRON-	PRP
cord-264884-ydkigome	317	15	was	be	VBD
cord-264884-ydkigome	317	16	less	less	RBR
cord-264884-ydkigome	317	17	pathogenic	pathogenic	JJ
cord-264884-ydkigome	317	18	in	in	IN
cord-264884-ydkigome	317	19	this	this	DT
cord-264884-ydkigome	317	20	mouse	mouse	NN
cord-264884-ydkigome	317	21	model	model	NN
cord-264884-ydkigome	317	22	and	and	CC
cord-264884-ydkigome	317	23	competed	compete	VBD
cord-264884-ydkigome	317	24	poorly	poorly	RB
cord-264884-ydkigome	317	25	with	with	IN
cord-264884-ydkigome	317	26	3D	3d	JJ
cord-264884-ydkigome	317	27	wild	wild	JJ
cord-264884-ydkigome	317	28	-	-	HYPH
cord-264884-ydkigome	317	29	type	type	NN
cord-264884-ydkigome	317	30	virus	virus	NN
cord-264884-ydkigome	317	31	.	.	.
cord-264884-ydkigome	318	1	It	-PRON-	PRP
cord-264884-ydkigome	318	2	seemed	seem	VBD
cord-264884-ydkigome	318	3	that	that	IN
cord-264884-ydkigome	318	4	the	the	DT
cord-264884-ydkigome	318	5	decreased	decrease	VBN
cord-264884-ydkigome	318	6	viral	viral	JJ
cord-264884-ydkigome	318	7	diversity	diversity	NN
cord-264884-ydkigome	318	8	was	be	VBD
cord-264884-ydkigome	318	9	less	less	RBR
cord-264884-ydkigome	318	10	able	able	JJ
cord-264884-ydkigome	318	11	to	to	TO
cord-264884-ydkigome	318	12	generate	generate	VB
cord-264884-ydkigome	318	13	the	the	DT
cord-264884-ydkigome	318	14	variation	variation	NN
cord-264884-ydkigome	318	15	needed	need	VBN
cord-264884-ydkigome	318	16	to	to	TO
cord-264884-ydkigome	318	17	get	get	VB
cord-264884-ydkigome	318	18	past	past	JJ
cord-264884-ydkigome	318	19	bottlenecks	bottleneck	NNS
cord-264884-ydkigome	318	20	due	due	JJ
cord-264884-ydkigome	318	21	to	to	IN
cord-264884-ydkigome	318	22	multiple	multiple	JJ
cord-264884-ydkigome	318	23	selective	selective	JJ
cord-264884-ydkigome	318	24	differences	difference	NNS
cord-264884-ydkigome	318	25	presented	present	VBN
cord-264884-ydkigome	318	26	in	in	IN
cord-264884-ydkigome	318	27	vivo	vivo	NN
cord-264884-ydkigome	318	28	in	in	IN
cord-264884-ydkigome	318	29	tissues	tissue	NNS
cord-264884-ydkigome	318	30	in	in	IN
cord-264884-ydkigome	318	31	the	the	DT
cord-264884-ydkigome	318	32	host	host	NN
cord-264884-ydkigome	318	33	,	,	,
cord-264884-ydkigome	318	34	such	such	JJ
cord-264884-ydkigome	318	35	as	as	IN
cord-264884-ydkigome	318	36	brain	brain	NN
cord-264884-ydkigome	318	37	infection	infection	NN
cord-264884-ydkigome	318	38	(	(	-LRB-
cord-264884-ydkigome	318	39	Pfeiffer	Pfeiffer	NNP
cord-264884-ydkigome	318	40	and	and	CC
cord-264884-ydkigome	318	41	Kirkegaard	Kirkegaard	NNP
cord-264884-ydkigome	318	42	,	,	,
cord-264884-ydkigome	318	43	2006	2006	CD
cord-264884-ydkigome	318	44	)	)	-RRB-
cord-264884-ydkigome	318	45	.	.	.
cord-264884-ydkigome	319	1	This	this	DT
cord-264884-ydkigome	319	2	experimental	experimental	JJ
cord-264884-ydkigome	319	3	system	system	NN
cord-264884-ydkigome	319	4	also	also	RB
cord-264884-ydkigome	319	5	makes	make	VBZ
cord-264884-ydkigome	319	6	clear	clear	JJ
cord-264884-ydkigome	319	7	the	the	DT
cord-264884-ydkigome	319	8	greater	great	JJR
cord-264884-ydkigome	319	9	complexity	complexity	NN
cord-264884-ydkigome	319	10	of	of	IN
cord-264884-ydkigome	319	11	fi	fi	NN
cord-264884-ydkigome	319	12	tness	tness	NN
cord-264884-ydkigome	319	13	in	in	IN
cord-264884-ydkigome	319	14	vivo	vivo	NN
cord-264884-ydkigome	319	15	relative	relative	NN
cord-264884-ydkigome	319	16	to	to	IN
cord-264884-ydkigome	319	17	that	that	DT
cord-264884-ydkigome	319	18	typically	typically	RB
cord-264884-ydkigome	319	19	measured	measure	VBN
cord-264884-ydkigome	319	20	in	in	IN
cord-264884-ydkigome	319	21	culture	culture	NN
cord-264884-ydkigome	319	22	.	.	.
cord-264884-ydkigome	320	1	Thus	thus	RB
cord-264884-ydkigome	320	2	it	-PRON-	PRP
cord-264884-ydkigome	320	3	seems	seem	VBZ
cord-264884-ydkigome	320	4	that	that	IN
cord-264884-ydkigome	320	5	in	in	IN
cord-264884-ydkigome	320	6	vivo	vivo	NN
cord-264884-ydkigome	320	7	there	there	EX
cord-264884-ydkigome	320	8	may	may	MD
cord-264884-ydkigome	320	9	not	not	RB
cord-264884-ydkigome	320	10	be	be	VB
cord-264884-ydkigome	320	11	one	one	CD
cord-264884-ydkigome	320	12	fi	fi	NN
cord-264884-ydkigome	320	13	tness	tness	NN
cord-264884-ydkigome	320	14	but	but	CC
cord-264884-ydkigome	320	15	several	several	JJ
cord-264884-ydkigome	320	16	that	that	WDT
cord-264884-ydkigome	320	17	can	can	MD
cord-264884-ydkigome	320	18	not	not	RB
cord-264884-ydkigome	320	19	be	be	VB
cord-264884-ydkigome	320	20	distinguished	distinguish	VBN
cord-264884-ydkigome	320	21	or	or	CC
cord-264884-ydkigome	320	22	individually	individually	RB
cord-264884-ydkigome	320	23	measured	measure	VBN
cord-264884-ydkigome	320	24	.	.	.
cord-264884-ydkigome	321	1	It	-PRON-	PRP
cord-264884-ydkigome	321	2	is	be	VBZ
cord-264884-ydkigome	321	3	likely	likely	JJ
cord-264884-ydkigome	321	4	that	that	IN
cord-264884-ydkigome	321	5	various	various	JJ
cord-264884-ydkigome	321	6	in	in	IN
cord-264884-ydkigome	321	7	vivo	vivo	NN
cord-264884-ydkigome	321	8	barriers	barrier	NNS
cord-264884-ydkigome	321	9	require	require	VBP
cord-264884-ydkigome	321	10	distinct	distinct	JJ
cord-264884-ydkigome	321	11	fi	fi	IN
cord-264884-ydkigome	321	12	tness	tness	NN
cord-264884-ydkigome	321	13	solutions	solution	NNS
cord-264884-ydkigome	321	14	that	that	WDT
cord-264884-ydkigome	321	15	tend	tend	VBP
cord-264884-ydkigome	321	16	to	to	TO
cord-264884-ydkigome	321	17	create	create	VB
cord-264884-ydkigome	321	18	bottlenecks	bottleneck	NNS
cord-264884-ydkigome	321	19	and	and	CC
cord-264884-ydkigome	321	20	that	that	IN
cord-264884-ydkigome	321	21	the	the	DT
cord-264884-ydkigome	321	22	diversity	diversity	NN
cord-264884-ydkigome	321	23	per	per	FW
cord-264884-ydkigome	321	24	se	se	FW
cord-264884-ydkigome	321	25	is	be	VBZ
cord-264884-ydkigome	321	26	essential	essential	JJ
cord-264884-ydkigome	321	27	to	to	TO
cord-264884-ydkigome	321	28	get	get	VB
cord-264884-ydkigome	321	29	past	past	IN
cord-264884-ydkigome	321	30	such	such	JJ
cord-264884-ydkigome	321	31	bottlenecks	bottleneck	NNS
cord-264884-ydkigome	321	32	.	.	.
cord-264884-ydkigome	322	1	A	a	DT
cord-264884-ydkigome	322	2	population	population	NN
cord-264884-ydkigome	322	3	,	,	,
cord-264884-ydkigome	322	4	not	not	RB
cord-264884-ydkigome	322	5	a	a	DT
cord-264884-ydkigome	322	6	clone	clone	NN
cord-264884-ydkigome	322	7	or	or	CC
cord-264884-ydkigome	322	8	a	a	DT
cord-264884-ydkigome	322	9	consensus	consensus	NN
cord-264884-ydkigome	322	10	,	,	,
cord-264884-ydkigome	322	11	appeared	appear	VBD
cord-264884-ydkigome	322	12	more	more	JJR
cord-264884-ydkigome	322	13	fi	fi	NN
cord-264884-ydkigome	322	14	t	t	NN
cord-264884-ydkigome	322	15	as	as	IN
cord-264884-ydkigome	322	16	higher	high	JJR
cord-264884-ydkigome	322	17	titer	titer	NN
cord-264884-ydkigome	322	18	infections	infection	NNS
cord-264884-ydkigome	322	19	of	of	IN
cord-264884-ydkigome	322	20	3DG64S	3dg64s	CD
cord-264884-ydkigome	322	21	also	also	RB
cord-264884-ydkigome	322	22	failed	fail	VBD
cord-264884-ydkigome	322	23	to	to	TO
cord-264884-ydkigome	322	24	be	be	VB
cord-264884-ydkigome	322	25	pathogenic	pathogenic	JJ
cord-264884-ydkigome	322	26	.	.	.
cord-264884-ydkigome	323	1	Thus	thus	RB
cord-264884-ydkigome	323	2	,	,	,
cord-264884-ydkigome	323	3	higher	high	JJR
cord-264884-ydkigome	323	4	levels	level	NNS
cord-264884-ydkigome	323	5	of	of	IN
cord-264884-ydkigome	323	6	a	a	DT
cord-264884-ydkigome	323	7	consensus	consensus	NN
cord-264884-ydkigome	323	8	virus	virus	NN
cord-264884-ydkigome	323	9	are	be	VBP
cord-264884-ydkigome	323	10	not	not	RB
cord-264884-ydkigome	323	11	equivalent	equivalent	JJ
cord-264884-ydkigome	323	12	to	to	IN
cord-264884-ydkigome	323	13	higher	high	JJR
cord-264884-ydkigome	323	14	diversity	diversity	NN
cord-264884-ydkigome	323	15	.	.	.
cord-264884-ydkigome	324	1	The	the	DT
cord-264884-ydkigome	324	2	relationship	relationship	NN
cord-264884-ydkigome	324	3	between	between	IN
cord-264884-ydkigome	324	4	RNA	RNA	NNP
cord-264884-ydkigome	324	5	polymerase	polymerase	NN
cord-264884-ydkigome	324	6	structure	structure	NN
cord-264884-ydkigome	324	7	,	,	,
cord-264884-ydkigome	324	8	error	error	NN
cord-264884-ydkigome	324	9	rates	rate	NNS
cord-264884-ydkigome	324	10	,	,	,
cord-264884-ydkigome	324	11	and	and	CC
cord-264884-ydkigome	324	12	ribavirin	ribavirin	JJ
cord-264884-ydkigome	324	13	action	action	NN
cord-264884-ydkigome	324	14	is	be	VBZ
cord-264884-ydkigome	324	15	discussed	discuss	VBN
cord-264884-ydkigome	324	16	by	by	IN
cord-264884-ydkigome	324	17	Cameron	Cameron	NNP
cord-264884-ydkigome	324	18	in	in	IN
cord-264884-ydkigome	324	19	Chapter	Chapter	NNP
cord-264884-ydkigome	324	20	6	6	CD
cord-264884-ydkigome	324	21	and	and	CC
cord-264884-ydkigome	324	22	has	have	VBZ
cord-264884-ydkigome	324	23	been	be	VBN
cord-264884-ydkigome	324	24	the	the	DT
cord-264884-ydkigome	324	25	subject	subject	NN
cord-264884-ydkigome	324	26	of	of	IN
cord-264884-ydkigome	324	27	numerous	numerous	JJ
cord-264884-ydkigome	324	28	studies	study	NNS
cord-264884-ydkigome	324	29	(	(	-LRB-
cord-264884-ydkigome	324	30	Crotty	Crotty	NNP
cord-264884-ydkigome	324	31	et	et	NNP
cord-264884-ydkigome	324	32	al	al	NNP
cord-264884-ydkigome	324	33	.	.	NNP
cord-264884-ydkigome	324	34	,	,	,
cord-264884-ydkigome	324	35	2001	2001	CD
cord-264884-ydkigome	324	36	;	;	:
cord-264884-ydkigome	324	37	Vignuzzi	Vignuzzi	NNP
cord-264884-ydkigome	324	38	et	et	NNP
cord-264884-ydkigome	324	39	al	al	NNP
cord-264884-ydkigome	324	40	.	.	NNP
cord-264884-ydkigome	324	41	,	,	,
cord-264884-ydkigome	324	42	2005	2005	CD
cord-264884-ydkigome	324	43	)	)	-RRB-
cord-264884-ydkigome	324	44	.	.	.
cord-264884-ydkigome	325	1	Knowledge	knowledge	NN
cord-264884-ydkigome	325	2	of	of	IN
cord-264884-ydkigome	325	3	the	the	DT
cord-264884-ydkigome	325	4	structure	structure	NN
cord-264884-ydkigome	325	5	and	and	CC
cord-264884-ydkigome	325	6	catalytic	catalytic	JJ
cord-264884-ydkigome	325	7	mechanism	mechanism	NN
cord-264884-ydkigome	325	8	of	of	IN
cord-264884-ydkigome	325	9	RNA	rna	NN
cord-264884-ydkigome	325	10	polymerase	polymerase	NN
cord-264884-ydkigome	325	11	function	function	NN
cord-264884-ydkigome	325	12	has	have	VBZ
cord-264884-ydkigome	325	13	allowed	allow	VBN
cord-264884-ydkigome	325	14	a	a	DT
cord-264884-ydkigome	325	15	greatly	greatly	RB
cord-264884-ydkigome	325	16	enhanced	enhanced	JJ
cord-264884-ydkigome	325	17	level	level	NN
cord-264884-ydkigome	325	18	of	of	IN
cord-264884-ydkigome	325	19	detail	detail	NN
cord-264884-ydkigome	325	20	to	to	TO
cord-264884-ydkigome	325	21	be	be	VB
cord-264884-ydkigome	325	22	considered	consider	VBN
cord-264884-ydkigome	325	23	into	into	IN
cord-264884-ydkigome	325	24	what	what	WP
cord-264884-ydkigome	325	25	affects	affect	VBZ
cord-264884-ydkigome	325	26	error	error	NN
cord-264884-ydkigome	325	27	rate	rate	NN
cord-264884-ydkigome	325	28	(	(	-LRB-
cord-264884-ydkigome	325	29	see	see	VB
cord-264884-ydkigome	325	30	Castro	Castro	NNP
cord-264884-ydkigome	325	31	et	et	NNP
cord-264884-ydkigome	325	32	al	al	NNP
cord-264884-ydkigome	325	33	.	.	NNP
cord-264884-ydkigome	325	34	,	,	,
cord-264884-ydkigome	325	35	2007	2007	CD
cord-264884-ydkigome	325	36	;	;	:
cord-264884-ydkigome	325	37	Korneeva	Korneeva	NNP
cord-264884-ydkigome	325	38	and	and	CC
cord-264884-ydkigome	325	39	Cameron	Cameron	NNP
cord-264884-ydkigome	325	40	,	,	,
cord-264884-ydkigome	325	41	2007	2007	CD
cord-264884-ydkigome	325	42	;	;	.
cord-264884-ydkigome	326	1	Marcotte	Marcotte	NNP
cord-264884-ydkigome	326	2	et	et	NNP
cord-264884-ydkigome	326	3	al	al	NNP
cord-264884-ydkigome	326	4	.	.	NNP
cord-264884-ydkigome	326	5	,	,	,
cord-264884-ydkigome	326	6	2007	2007	CD
cord-264884-ydkigome	326	7	)	)	-RRB-
cord-264884-ydkigome	326	8	.	.	.
cord-264884-ydkigome	327	1	This	this	DT
cord-264884-ydkigome	327	2	has	have	VBZ
cord-264884-ydkigome	327	3	provided	provide	VBN
cord-264884-ydkigome	327	4	insight	insight	NN
cord-264884-ydkigome	327	5	into	into	IN
cord-264884-ydkigome	327	6	the	the	DT
cord-264884-ydkigome	327	7	likely	likely	JJ
cord-264884-ydkigome	327	8	action	action	NN
cord-264884-ydkigome	327	9	of	of	IN
cord-264884-ydkigome	327	10	ribavarin	ribavarin	NNP
cord-264884-ydkigome	327	11	on	on	IN
cord-264884-ydkigome	327	12	product	product	NN
cord-264884-ydkigome	327	13	fi	fi	NN
cord-264884-ydkigome	327	14	delity	delity	NNP
cord-264884-ydkigome	327	15	(	(	-LRB-
cord-264884-ydkigome	327	16	Harki	Harki	NNP
cord-264884-ydkigome	327	17	et	et	NNP
cord-264884-ydkigome	327	18	al	al	NNP
cord-264884-ydkigome	327	19	.	.	NNP
cord-264884-ydkigome	327	20	,	,	,
cord-264884-ydkigome	327	21	2002	2002	CD
cord-264884-ydkigome	327	22	)	)	-RRB-
cord-264884-ydkigome	327	23	.	.	.
cord-264884-ydkigome	328	1	Thus	thus	RB
cord-264884-ydkigome	328	2	,	,	,
cord-264884-ydkigome	328	3	it	-PRON-	PRP
cord-264884-ydkigome	328	4	appeared	appear	VBD
cord-264884-ydkigome	328	5	that	that	IN
cord-264884-ydkigome	328	6	even	even	RB
cord-264884-ydkigome	328	7	a	a	DT
cord-264884-ydkigome	328	8	mutant	mutant	NN
cord-264884-ydkigome	328	9	of	of	IN
cord-264884-ydkigome	328	10	RNA	RNA	NNP
cord-264884-ydkigome	328	11	polymerase	polymerase	NN
cord-264884-ydkigome	328	12	with	with	IN
cord-264884-ydkigome	328	13	increased	increase	VBN
cord-264884-ydkigome	328	14	fi	fi	NN
cord-264884-ydkigome	328	15	delity	delity	NN
cord-264884-ydkigome	328	16	could	could	MD
cord-264884-ydkigome	328	17	still	still	RB
cord-264884-ydkigome	328	18	generate	generate	VB
cord-264884-ydkigome	328	19	elevated	elevated	JJ
cord-264884-ydkigome	328	20	diversity	diversity	NN
cord-264884-ydkigome	328	21	by	by	IN
cord-264884-ydkigome	328	22	various	various	JJ
cord-264884-ydkigome	328	23	methods	method	NNS
cord-264884-ydkigome	328	24	.	.	.
cord-264884-ydkigome	329	1	Such	such	JJ
cord-264884-ydkigome	329	2	control	control	NN
cord-264884-ydkigome	329	3	of	of	IN
cord-264884-ydkigome	329	4	fi	fi	NNP
cord-264884-ydkigome	329	5	delity	delity	NNP
cord-264884-ydkigome	329	6	allowed	allow	VBN
cord-264884-ydkigome	329	7	for	for	IN
cord-264884-ydkigome	329	8	the	the	DT
cord-264884-ydkigome	329	9	design	design	NN
cord-264884-ydkigome	329	10	of	of	IN
cord-264884-ydkigome	329	11	control	control	NN
cord-264884-ydkigome	329	12	experiments	experiment	NNS
cord-264884-ydkigome	329	13	in	in	IN
cord-264884-ydkigome	329	14	which	which	WDT
cord-264884-ydkigome	329	15	the	the	DT
cord-264884-ydkigome	329	16	same	same	JJ
cord-264884-ydkigome	329	17	consensus	consensus	NN
cord-264884-ydkigome	329	18	virus	virus	NN
cord-264884-ydkigome	329	19	genome	genome	NN
cord-264884-ydkigome	329	20	could	could	MD
cord-264884-ydkigome	329	21	be	be	VB
cord-264884-ydkigome	329	22	forced	force	VBN
cord-264884-ydkigome	329	23	to	to	TO
cord-264884-ydkigome	329	24	generate	generate	VB
cord-264884-ydkigome	329	25	either	either	CC
cord-264884-ydkigome	329	26	less	less	JJR
cord-264884-ydkigome	329	27	or	or	CC
cord-264884-ydkigome	329	28	more	more	RBR
cord-264884-ydkigome	329	29	diverse	diverse	JJ
cord-264884-ydkigome	329	30	progeny	progeny	JJ
cord-264884-ydkigome	329	31	populations	population	NNS
cord-264884-ydkigome	329	32	.	.	.
cord-264884-ydkigome	330	1	In	in	IN
cord-264884-ydkigome	330	2	no	no	DT
cord-264884-ydkigome	330	3	other	other	JJ
cord-264884-ydkigome	330	4	virus	virus	NN
cord-264884-ydkigome	330	5	-	-	HYPH
cord-264884-ydkigome	330	6	host	host	NN
cord-264884-ydkigome	330	7	system	system	NN
cord-264884-ydkigome	330	8	have	have	VBP
cord-264884-ydkigome	330	9	we	-PRON-	PRP
cord-264884-ydkigome	330	10	attained	attain	VBN
cord-264884-ydkigome	330	11	such	such	JJ
cord-264884-ydkigome	330	12	detailed	detailed	JJ
cord-264884-ydkigome	330	13	insight	insight	NN
cord-264884-ydkigome	330	14	into	into	IN
cord-264884-ydkigome	330	15	issues	issue	NNS
cord-264884-ydkigome	330	16	of	of	IN
cord-264884-ydkigome	330	17	error	error	NN
cord-264884-ydkigome	330	18	rate	rate	NN
cord-264884-ydkigome	330	19	as	as	IN
cord-264884-ydkigome	330	20	those	those	DT
cord-264884-ydkigome	330	21	that	that	WDT
cord-264884-ydkigome	330	22	were	be	VBD
cord-264884-ydkigome	330	23	put	put	VBN
cord-264884-ydkigome	330	24	to	to	IN
cord-264884-ydkigome	330	25	such	such	JJ
cord-264884-ydkigome	330	26	excellent	excellent	JJ
cord-264884-ydkigome	330	27	use	use	NN
cord-264884-ydkigome	330	28	in	in	IN
cord-264884-ydkigome	330	29	the	the	DT
cord-264884-ydkigome	330	30	poliovirus	poliovirus	NN
cord-264884-ydkigome	330	31	-	-	HYPH
cord-264884-ydkigome	330	32	mouse	mouse	NN
cord-264884-ydkigome	330	33	system	system	NN
cord-264884-ydkigome	330	34	.	.	.
cord-264884-ydkigome	331	1	How	how	WRB
cord-264884-ydkigome	331	2	generally	generally	RB
cord-264884-ydkigome	331	3	important	important	JJ
cord-264884-ydkigome	331	4	is	be	VBZ
cord-264884-ydkigome	331	5	this	this	DT
cord-264884-ydkigome	331	6	poliovirus	poliovirus	NN
cord-264884-ydkigome	331	7	in	in	IN
cord-264884-ydkigome	331	8	vivo	vivo	NN
cord-264884-ydkigome	331	9	quasispecies	quasispecie	NNS
cord-264884-ydkigome	331	10	result	result	VB
cord-264884-ydkigome	331	11	?	?	.
cord-264884-ydkigome	332	1	Although	although	IN
cord-264884-ydkigome	332	2	the	the	DT
cord-264884-ydkigome	332	3	poliovirus	poliovirus	NN
cord-264884-ydkigome	332	4	-	-	HYPH
cord-264884-ydkigome	332	5	mouse	mouse	NN
cord-264884-ydkigome	332	6	system	system	NN
cord-264884-ydkigome	332	7	provides	provide	VBZ
cord-264884-ydkigome	332	8	us	-PRON-	PRP
cord-264884-ydkigome	332	9	with	with	IN
cord-264884-ydkigome	332	10	a	a	DT
cord-264884-ydkigome	332	11	fi	fi	NNP
cord-264884-ydkigome	332	12	rm	rm	NNP
cord-264884-ydkigome	332	13	experimental	experimental	JJ
cord-264884-ydkigome	332	14	result	result	NN
cord-264884-ydkigome	332	15	,	,	,
cord-264884-ydkigome	332	16	it	-PRON-	PRP
cord-264884-ydkigome	332	17	seems	seem	VBZ
cord-264884-ydkigome	332	18	likely	likely	JJ
cord-264884-ydkigome	332	19	that	that	IN
cord-264884-ydkigome	332	20	the	the	DT
cord-264884-ydkigome	332	21	generality	generality	NN
cord-264884-ydkigome	332	22	of	of	IN
cord-264884-ydkigome	332	23	this	this	DT
cord-264884-ydkigome	332	24	relationship	relationship	NN
cord-264884-ydkigome	332	25	will	will	MD
cord-264884-ydkigome	332	26	be	be	VB
cord-264884-ydkigome	332	27	questioned	question	VBN
cord-264884-ydkigome	332	28	by	by	IN
cord-264884-ydkigome	332	29	evolutionary	evolutionary	JJ
cord-264884-ydkigome	332	30	biologists	biologist	NNS
cord-264884-ydkigome	332	31	for	for	IN
cord-264884-ydkigome	332	32	several	several	JJ
cord-264884-ydkigome	332	33	reasons	reason	NNS
cord-264884-ydkigome	332	34	.	.	.
cord-264884-ydkigome	333	1	For	for	IN
cord-264884-ydkigome	333	2	one	one	CD
cord-264884-ydkigome	333	3	,	,	,
cord-264884-ydkigome	333	4	this	this	DT
cord-264884-ydkigome	333	5	was	be	VBD
cord-264884-ydkigome	333	6	observed	observe	VBN
cord-264884-ydkigome	333	7	in	in	IN
cord-264884-ydkigome	333	8	a	a	DT
cord-264884-ydkigome	333	9	lab	lab	NN
cord-264884-ydkigome	333	10	constructed	construct	VBN
cord-264884-ydkigome	333	11	model	model	NN
cord-264884-ydkigome	333	12	system	system	NN
cord-264884-ydkigome	333	13	,	,	,
cord-264884-ydkigome	333	14	which	which	WDT
cord-264884-ydkigome	333	15	,	,	,
cord-264884-ydkigome	333	16	it	-PRON-	PRP
cord-264884-ydkigome	333	17	could	could	MD
cord-264884-ydkigome	333	18	be	be	VB
cord-264884-ydkigome	333	19	argued	argue	VBN
cord-264884-ydkigome	333	20	,	,	,
cord-264884-ydkigome	333	21	is	be	VBZ
cord-264884-ydkigome	333	22	not	not	RB
cord-264884-ydkigome	333	23	an	an	DT
cord-264884-ydkigome	333	24	accurate	accurate	JJ
cord-264884-ydkigome	333	25	representation	representation	NN
cord-264884-ydkigome	333	26	of	of	IN
cord-264884-ydkigome	333	27	in	in	IN
cord-264884-ydkigome	333	28	vivo	vivo	NNP
cord-264884-ydkigome	333	29	virus	virus	NN
cord-264884-ydkigome	333	30	-	-	HYPH
cord-264884-ydkigome	333	31	host	host	NN
cord-264884-ydkigome	333	32	fi	fi	NN
cord-264884-ydkigome	333	33	tness	tness	NN
cord-264884-ydkigome	333	34	.	.	.
cord-264884-ydkigome	334	1	Also	also	RB
cord-264884-ydkigome	334	2	,	,	,
cord-264884-ydkigome	334	3	as	as	IN
cord-264884-ydkigome	334	4	mentioned	mention	VBN
cord-264884-ydkigome	334	5	above	above	RB
cord-264884-ydkigome	334	6	,	,	,
cord-264884-ydkigome	334	7	group	group	NN
cord-264884-ydkigome	334	8	selection	selection	NN
cord-264884-ydkigome	334	9	is	be	VBZ
cord-264884-ydkigome	334	10	a	a	DT
cord-264884-ydkigome	334	11	process	process	NN
cord-264884-ydkigome	334	12	that	that	WDT
cord-264884-ydkigome	334	13	will	will	MD
cord-264884-ydkigome	334	14	not	not	RB
cord-264884-ydkigome	334	15	readily	readily	RB
cord-264884-ydkigome	334	16	be	be	VB
cord-264884-ydkigome	334	17	accepted	accept	VBN
cord-264884-ydkigome	334	18	as	as	IN
cord-264884-ydkigome	334	19	representative	representative	NN
cord-264884-ydkigome	334	20	by	by	IN
cord-264884-ydkigome	334	21	the	the	DT
cord-264884-ydkigome	334	22	broader	broad	JJR
cord-264884-ydkigome	334	23	community	community	NN
cord-264884-ydkigome	334	24	.	.	.
cord-264884-ydkigome	335	1	Is	be	VBZ
cord-264884-ydkigome	335	2	there	there	EX
cord-264884-ydkigome	335	3	any	any	DT
cord-264884-ydkigome	335	4	evidence	evidence	NN
cord-264884-ydkigome	335	5	that	that	IN
cord-264884-ydkigome	335	6	this	this	DT
cord-264884-ydkigome	335	7	result	result	NN
cord-264884-ydkigome	335	8	with	with	IN
cord-264884-ydkigome	335	9	poliovirus	poliovirus	NN
cord-264884-ydkigome	335	10	indeed	indeed	RB
cord-264884-ydkigome	335	11	represents	represent	VBZ
cord-264884-ydkigome	335	12	a	a	DT
cord-264884-ydkigome	335	13	general	general	JJ
cord-264884-ydkigome	335	14	virus	virus	NN
cord-264884-ydkigome	335	15	-	-	HYPH
cord-264884-ydkigome	335	16	host	host	NN
cord-264884-ydkigome	335	17	evolutionary	evolutionary	JJ
cord-264884-ydkigome	335	18	relationship	relationship	NN
cord-264884-ydkigome	335	19	in	in	IN
cord-264884-ydkigome	335	20	natural	natural	JJ
cord-264884-ydkigome	335	21	settings	setting	NNS
cord-264884-ydkigome	335	22	?	?	.
cord-264884-ydkigome	336	1	As	as	IN
cord-264884-ydkigome	336	2	presented	present	VBN
cord-264884-ydkigome	336	3	in	in	IN
cord-264884-ydkigome	336	4	Chapters	Chapters	NNPS
cord-264884-ydkigome	336	5	13	13	CD
cord-264884-ydkigome	336	6	-	-	SYM
cord-264884-ydkigome	336	7	15	15	CD
cord-264884-ydkigome	336	8	,	,	,
cord-264884-ydkigome	336	9	retroviruses	retrovirus	NNS
cord-264884-ydkigome	336	10	and	and	CC
cord-264884-ydkigome	336	11	also	also	RB
cord-264884-ydkigome	336	12	human	human	JJ
cord-264884-ydkigome	336	13	hepatitis	hepatitis	NN
cord-264884-ydkigome	336	14	virus	virus	NN
cord-264884-ydkigome	336	15	C	C	NNP
cord-264884-ydkigome	336	16	clearly	clearly	RB
cord-264884-ydkigome	336	17	exist	exist	VBP
cord-264884-ydkigome	336	18	as	as	IN
cord-264884-ydkigome	336	19	quasispecies	quasispecie	NNS
cord-264884-ydkigome	336	20	populations	population	NNS
cord-264884-ydkigome	336	21	that	that	WDT
cord-264884-ydkigome	336	22	affect	affect	VBP
cord-264884-ydkigome	336	23	disease	disease	NN
cord-264884-ydkigome	336	24	outcome	outcome	NN
cord-264884-ydkigome	336	25	.	.	.
cord-264884-ydkigome	337	1	In	in	IN
cord-264884-ydkigome	337	2	the	the	DT
cord-264884-ydkigome	337	3	case	case	NN
cord-264884-ydkigome	337	4	of	of	IN
cord-264884-ydkigome	337	5	the	the	DT
cord-264884-ydkigome	337	6	retroviruses	retrovirus	NNS
cord-264884-ydkigome	337	7	,	,	,
cord-264884-ydkigome	337	8	viral	viral	JJ
cord-264884-ydkigome	337	9	populations	population	NNS
cord-264884-ydkigome	337	10	show	show	VBP
cord-264884-ydkigome	337	11	diversity	diversity	NN
cord-264884-ydkigome	337	12	that	that	WDT
cord-264884-ydkigome	337	13	far	far	RB
cord-264884-ydkigome	337	14	exceeds	exceed	VBZ
cord-264884-ydkigome	337	15	that	that	WDT
cord-264884-ydkigome	337	16	seen	see	VBN
cord-264884-ydkigome	337	17	for	for	IN
cord-264884-ydkigome	337	18	other	other	JJ
cord-264884-ydkigome	337	19	RNA	RNA	NNP
cord-264884-ydkigome	337	20	viruses	virus	NNS
cord-264884-ydkigome	337	21	.	.	.
cord-264884-ydkigome	338	1	In	in	IN
cord-264884-ydkigome	338	2	both	both	DT
cord-264884-ydkigome	338	3	HIV-1	HIV-1	NNP
cord-264884-ydkigome	338	4	and	and	CC
cord-264884-ydkigome	338	5	HCV	HCV	NNP
cord-264884-ydkigome	338	6	there	there	EX
cord-264884-ydkigome	338	7	is	be	VBZ
cord-264884-ydkigome	338	8	clear	clear	JJ
cord-264884-ydkigome	338	9	circumstantial	circumstantial	JJ
cord-264884-ydkigome	338	10	evidence	evidence	NN
cord-264884-ydkigome	338	11	for	for	IN
cord-264884-ydkigome	338	12	the	the	DT
cord-264884-ydkigome	338	13	importance	importance	NN
cord-264884-ydkigome	338	14	of	of	IN
cord-264884-ydkigome	338	15	quasispecies	quasispecie	NNS
cord-264884-ydkigome	338	16	for	for	IN
cord-264884-ydkigome	338	17	in	in	IN
cord-264884-ydkigome	338	18	vivo	vivo	FW
cord-264884-ydkigome	338	19	disease	disease	NN
cord-264884-ydkigome	338	20	outcome	outcome	NN
cord-264884-ydkigome	338	21	,	,	,
cord-264884-ydkigome	338	22	drug	drug	NN
cord-264884-ydkigome	338	23	resistance	resistance	NN
cord-264884-ydkigome	338	24	,	,	,
cord-264884-ydkigome	338	25	and	and	CC
cord-264884-ydkigome	338	26	fi	fi	NNP
cord-264884-ydkigome	338	27	tness	tness	NN
cord-264884-ydkigome	338	28	.	.	.
cord-264884-ydkigome	339	1	In	in	IN
cord-264884-ydkigome	339	2	addition	addition	NN
cord-264884-ydkigome	339	3	,	,	,
cord-264884-ydkigome	339	4	with	with	IN
cord-264884-ydkigome	339	5	HCV	HCV	NNP
cord-264884-ydkigome	339	6	,	,	,
cord-264884-ydkigome	339	7	CNS	CNS	NNP
cord-264884-ydkigome	339	8	infection	infection	NN
cord-264884-ydkigome	339	9	may	may	MD
cord-264884-ydkigome	339	10	sometimes	sometimes	RB
cord-264884-ydkigome	339	11	result	result	VB
cord-264884-ydkigome	339	12	,	,	,
cord-264884-ydkigome	339	13	and	and	CC
cord-264884-ydkigome	339	14	such	such	JJ
cord-264884-ydkigome	339	15	brain	brain	NN
cord-264884-ydkigome	339	16	infections	infection	NNS
cord-264884-ydkigome	339	17	appear	appear	VBP
cord-264884-ydkigome	339	18	to	to	TO
cord-264884-ydkigome	339	19	be	be	VB
cord-264884-ydkigome	339	20	mediated	mediate	VBN
cord-264884-ydkigome	339	21	by	by	IN
cord-264884-ydkigome	339	22	distinct	distinct	JJ
cord-264884-ydkigome	339	23	quasispecies	quasispecie	NNS
cord-264884-ydkigome	339	24	(	(	-LRB-
cord-264884-ydkigome	339	25	Forton	Forton	NNP
cord-264884-ydkigome	339	26	et	et	FW
cord-264884-ydkigome	339	27	al	al	NNP
cord-264884-ydkigome	339	28	.	.	NNP
cord-264884-ydkigome	339	29	,	,	,
cord-264884-ydkigome	339	30	2004	2004	CD
cord-264884-ydkigome	339	31	;	;	:
cord-264884-ydkigome	340	1	Forton	Forton	NNP
cord-264884-ydkigome	340	2	et	et	FW
cord-264884-ydkigome	340	3	al	al	NNP
cord-264884-ydkigome	340	4	.	.	NNP
cord-264884-ydkigome	340	5	,	,	,
cord-264884-ydkigome	340	6	2006	2006	CD
cord-264884-ydkigome	340	7	)	)	-RRB-
cord-264884-ydkigome	340	8	,	,	,
cord-264884-ydkigome	340	9	reminiscent	reminiscent	JJ
cord-264884-ydkigome	340	10	of	of	IN
cord-264884-ydkigome	340	11	the	the	DT
cord-264884-ydkigome	340	12	polio	polio	NN
cord-264884-ydkigome	340	13	virus	virus	NN
cord-264884-ydkigome	340	14	mouse	mouse	NN
cord-264884-ydkigome	340	15	model	model	NN
cord-264884-ydkigome	340	16	.	.	.
cord-264884-ydkigome	341	1	Quasispecies	Quasispecies	NNP
cord-264884-ydkigome	341	2	memory	memory	NN
cord-264884-ydkigome	341	3	,	,	,
cord-264884-ydkigome	341	4	as	as	IN
cord-264884-ydkigome	341	5	mentioned	mention	VBN
cord-264884-ydkigome	341	6	above	above	RB
cord-264884-ydkigome	341	7	,	,	,
cord-264884-ydkigome	341	8	also	also	RB
cord-264884-ydkigome	341	9	seems	seem	VBZ
cord-264884-ydkigome	341	10	to	to	TO
cord-264884-ydkigome	341	11	be	be	VB
cord-264884-ydkigome	341	12	an	an	DT
cord-264884-ydkigome	341	13	important	important	JJ
cord-264884-ydkigome	341	14	issue	issue	NN
cord-264884-ydkigome	341	15	with	with	IN
cord-264884-ydkigome	341	16	regard	regard	NN
cord-264884-ydkigome	341	17	to	to	IN
cord-264884-ydkigome	341	18	failure	failure	NN
cord-264884-ydkigome	341	19	of	of	IN
cord-264884-ydkigome	341	20	antiretroviral	antiretroviral	JJ
cord-264884-ydkigome	341	21	therapy	therapy	NN
cord-264884-ydkigome	341	22	(	(	-LRB-
cord-264884-ydkigome	341	23	Kijak	Kijak	NNP
cord-264884-ydkigome	341	24	et	et	NNP
cord-264884-ydkigome	341	25	al	al	NNP
cord-264884-ydkigome	341	26	.	.	NNP
cord-264884-ydkigome	341	27	,	,	,
cord-264884-ydkigome	341	28	2002	2002	CD
cord-264884-ydkigome	341	29	)	)	-RRB-
cord-264884-ydkigome	342	1	and	and	CC
cord-264884-ydkigome	342	2	it	-PRON-	PRP
cord-264884-ydkigome	342	3	appears	appear	VBZ
cord-264884-ydkigome	342	4	that	that	IN
cord-264884-ydkigome	342	5	pol	pol	NN
cord-264884-ydkigome	342	6	gene	gene	NN
cord-264884-ydkigome	342	7	mutations	mutation	NNS
cord-264884-ydkigome	342	8	could	could	MD
cord-264884-ydkigome	342	9	also	also	RB
cord-264884-ydkigome	342	10	be	be	VB
cord-264884-ydkigome	342	11	involved	involve	VBN
cord-264884-ydkigome	342	12	in	in	IN
cord-264884-ydkigome	342	13	this	this	DT
cord-264884-ydkigome	342	14	(	(	-LRB-
cord-264884-ydkigome	342	15	Carobene	Carobene	NNP
cord-264884-ydkigome	342	16	et	et	NNP
cord-264884-ydkigome	342	17	al	al	NNP
cord-264884-ydkigome	342	18	.	.	NNP
cord-264884-ydkigome	342	19	,	,	,
cord-264884-ydkigome	342	20	2004	2004	CD
cord-264884-ydkigome	342	21	)	)	-RRB-
cord-264884-ydkigome	342	22	.	.	.
cord-264884-ydkigome	343	1	Measurements	measurement	NNS
cord-264884-ydkigome	343	2	of	of	IN
cord-264884-ydkigome	343	3	HIV	HIV	NNP
cord-264884-ydkigome	343	4	quasispecies	quasispecie	NNS
cord-264884-ydkigome	343	5	in	in	IN
cord-264884-ydkigome	343	6	individual	individual	JJ
cord-264884-ydkigome	343	7	patients	patient	NNS
cord-264884-ydkigome	343	8	indicates	indicate	VBZ
cord-264884-ydkigome	343	9	that	that	IN
cord-264884-ydkigome	343	10	multiple	multiple	JJ
cord-264884-ydkigome	343	11	evolutionary	evolutionary	JJ
cord-264884-ydkigome	343	12	patterns	pattern	NNS
cord-264884-ydkigome	343	13	can	can	MD
cord-264884-ydkigome	343	14	be	be	VB
cord-264884-ydkigome	343	15	found	find	VBN
cord-264884-ydkigome	343	16	in	in	IN
cord-264884-ydkigome	343	17	typical	typical	JJ
cord-264884-ydkigome	343	18	individual	individual	JJ
cord-264884-ydkigome	343	19	patients	patient	NNS
cord-264884-ydkigome	343	20	(	(	-LRB-
cord-264884-ydkigome	344	1	Casado	Casado	NNP
cord-264884-ydkigome	344	2	et	et	FW
cord-264884-ydkigome	344	3	al	al	NNP
cord-264884-ydkigome	344	4	.	.	.
cord-264884-ydkigome	345	1	,	,	,
cord-264884-ydkigome	345	2	2001	2001	CD
cord-264884-ydkigome	345	3	)	)	-RRB-
cord-264884-ydkigome	345	4	,	,	,
cord-264884-ydkigome	345	5	thus	thus	RB
cord-264884-ydkigome	345	6	mixtures	mixture	NNS
cord-264884-ydkigome	345	7	of	of	IN
cord-264884-ydkigome	345	8	HIV	HIV	NNP
cord-264884-ydkigome	345	9	exist	exist	VBP
cord-264884-ydkigome	345	10	in	in	IN
cord-264884-ydkigome	345	11	patients	patient	NNS
cord-264884-ydkigome	345	12	(	(	-LRB-
cord-264884-ydkigome	345	13	Bello	Bello	NNP
cord-264884-ydkigome	345	14	et	et	FW
cord-264884-ydkigome	345	15	al	al	NNP
cord-264884-ydkigome	345	16	.	.	.
cord-264884-ydkigome	346	1	,	,	,
cord-264884-ydkigome	346	2	2004	2004	CD
cord-264884-ydkigome	347	1	(	(	-LRB-
cord-264884-ydkigome	347	2	Bello	Bello	NNP
cord-264884-ydkigome	347	3	et	et	FW
cord-264884-ydkigome	347	4	al	al	NNP
cord-264884-ydkigome	347	5	.	.	NNP
cord-264884-ydkigome	347	6	,	,	,
cord-264884-ydkigome	347	7	,	,	,
cord-264884-ydkigome	347	8	2005	2005	CD
cord-264884-ydkigome	347	9	.	.	.
cord-264884-ydkigome	348	1	And	and	CC
cord-264884-ydkigome	348	2	HIV-1	HIV-1	NNP
cord-264884-ydkigome	348	3	recombination	recombination	NN
cord-264884-ydkigome	348	4	is	be	VBZ
cord-264884-ydkigome	348	5	clearly	clearly	RB
cord-264884-ydkigome	348	6	contributing	contribute	VBG
cord-264884-ydkigome	348	7	to	to	IN
cord-264884-ydkigome	348	8	diversity	diversity	NN
cord-264884-ydkigome	348	9	(	(	-LRB-
cord-264884-ydkigome	348	10	Kijak	Kijak	NNP
cord-264884-ydkigome	348	11	and	and	CC
cord-264884-ydkigome	348	12	McCutchan	McCutchan	NNP
cord-264884-ydkigome	348	13	,	,	,
cord-264884-ydkigome	348	14	2005	2005	CD
cord-264884-ydkigome	348	15	)	)	-RRB-
cord-264884-ydkigome	348	16	.	.	.
cord-264884-ydkigome	349	1	Thus	thus	RB
cord-264884-ydkigome	349	2	,	,	,
cord-264884-ydkigome	349	3	with	with	IN
cord-264884-ydkigome	349	4	both	both	CC
cord-264884-ydkigome	349	5	HIV-1	HIV-1	NNP
cord-264884-ydkigome	349	6	and	and	CC
cord-264884-ydkigome	349	7	HCV	HCV	NNP
cord-264884-ydkigome	349	8	,	,	,
cord-264884-ydkigome	349	9	their	-PRON-	PRP$
cord-264884-ydkigome	349	10	capacity	capacity	NN
cord-264884-ydkigome	349	11	to	to	TO
cord-264884-ydkigome	349	12	cause	cause	VB
cord-264884-ydkigome	349	13	human	human	JJ
cord-264884-ydkigome	349	14	disease	disease	NN
cord-264884-ydkigome	349	15	is	be	VBZ
cord-264884-ydkigome	349	16	clearly	clearly	RB
cord-264884-ydkigome	349	17	associated	associate	VBN
cord-264884-ydkigome	349	18	with	with	IN
cord-264884-ydkigome	349	19	quasispecies	quasispecie	NNS
cord-264884-ydkigome	349	20	compositions	composition	NNS
cord-264884-ydkigome	349	21	that	that	WDT
cord-264884-ydkigome	349	22	affect	affect	VBP
cord-264884-ydkigome	349	23	fi	fi	IN
cord-264884-ydkigome	349	24	tness	tness	NN
cord-264884-ydkigome	349	25	in	in	IN
cord-264884-ydkigome	349	26	complex	complex	JJ
cord-264884-ydkigome	349	27	ways	way	NNS
cord-264884-ydkigome	349	28	.	.	.
cord-264884-ydkigome	350	1	The	the	DT
cord-264884-ydkigome	350	2	poliovirus	poliovirus	NN
cord-264884-ydkigome	350	3	mouse	mouse	NN
cord-264884-ydkigome	350	4	system	system	NN
cord-264884-ydkigome	350	5	therefore	therefore	RB
cord-264884-ydkigome	350	6	appears	appear	VBZ
cord-264884-ydkigome	350	7	to	to	TO
cord-264884-ydkigome	350	8	refl	refl	NNP
cord-264884-ydkigome	350	9	ect	ect	NNP
cord-264884-ydkigome	350	10	quasispecies	quasispecies	NNP
cord-264884-ydkigome	350	11	issues	issue	NNS
cord-264884-ydkigome	350	12	as	as	IN
cord-264884-ydkigome	350	13	observed	observe	VBN
cord-264884-ydkigome	350	14	in	in	IN
cord-264884-ydkigome	350	15	natural	natural	JJ
cord-264884-ydkigome	350	16	virus	virus	NN
cord-264884-ydkigome	350	17	-	-	HYPH
cord-264884-ydkigome	350	18	host	host	NN
cord-264884-ydkigome	350	19	situations	situation	NNS
cord-264884-ydkigome	350	20	.	.	.
cord-264884-ydkigome	351	1	Consideration	consideration	NN
cord-264884-ydkigome	351	2	of	of	IN
cord-264884-ydkigome	351	3	retrovirus	retrovirus	NN
cord-264884-ydkigome	351	4	-	-	HYPH
cord-264884-ydkigome	351	5	host	host	NN
cord-264884-ydkigome	351	6	evolution	evolution	NN
cord-264884-ydkigome	351	7	introduces	introduce	VBZ
cord-264884-ydkigome	351	8	another	another	DT
cord-264884-ydkigome	351	9	large	large	JJ
cord-264884-ydkigome	351	10	issue	issue	NN
cord-264884-ydkigome	351	11	in	in	IN
cord-264884-ydkigome	351	12	evolution	evolution	NN
cord-264884-ydkigome	351	13	:	:	:
cord-264884-ydkigome	351	14	genomic	genomic	JJ
cord-264884-ydkigome	351	15	viruses	virus	NNS
cord-264884-ydkigome	351	16	.	.	.
cord-264884-ydkigome	352	1	Unlike	unlike	IN
cord-264884-ydkigome	352	2	poliovirus	poliovirus	NN
cord-264884-ydkigome	352	3	and	and	CC
cord-264884-ydkigome	352	4	most	most	JJS
cord-264884-ydkigome	352	5	RNA	RNA	NNP
cord-264884-ydkigome	352	6	viruses	virus	NNS
cord-264884-ydkigome	352	7	,	,	,
cord-264884-ydkigome	352	8	retroviruses	retrovirus	NNS
cord-264884-ydkigome	352	9	(	(	-LRB-
cord-264884-ydkigome	352	10	e.g.	e.g.	IN
cord-264884-ydkigome	352	11	non	non	JJ
cord-264884-ydkigome	352	12	-	-	JJ
cord-264884-ydkigome	352	13	lentivirus	lentivirus	JJ
cord-264884-ydkigome	352	14	)	)	-RRB-
cord-264884-ydkigome	352	15	have	have	VBP
cord-264884-ydkigome	352	16	colonized	colonize	VBN
cord-264884-ydkigome	352	17	the	the	DT
cord-264884-ydkigome	352	18	genomes	genome	NNS
cord-264884-ydkigome	352	19	of	of	IN
cord-264884-ydkigome	352	20	animal	animal	NN
cord-264884-ydkigome	352	21	species	specie	NNS
cord-264884-ydkigome	352	22	in	in	IN
cord-264884-ydkigome	352	23	large	large	JJ
cord-264884-ydkigome	352	24	numbers	number	NNS
cord-264884-ydkigome	352	25	and	and	CC
cord-264884-ydkigome	352	26	represent	represent	VBP
cord-264884-ydkigome	352	27	a	a	DT
cord-264884-ydkigome	352	28	large	large	JJ
cord-264884-ydkigome	352	29	fraction	fraction	NN
cord-264884-ydkigome	352	30	of	of	IN
cord-264884-ydkigome	352	31	these	these	DT
cord-264884-ydkigome	352	32	genomes	genome	NNS
cord-264884-ydkigome	352	33	.	.	.
cord-264884-ydkigome	353	1	Genomic	genomic	JJ
cord-264884-ydkigome	353	2	retroviruses	retrovirus	NNS
cord-264884-ydkigome	353	3	are	be	VBP
cord-264884-ydkigome	353	4	present	present	JJ
cord-264884-ydkigome	353	5	in	in	IN
cord-264884-ydkigome	353	6	vast	vast	JJ
cord-264884-ydkigome	353	7	numbers	number	NNS
cord-264884-ydkigome	353	8	,	,	,
cord-264884-ydkigome	353	9	most	most	JJS
cord-264884-ydkigome	353	10	of	of	IN
cord-264884-ydkigome	353	11	which	which	WDT
cord-264884-ydkigome	353	12	are	be	VBP
cord-264884-ydkigome	353	13	defective	defective	JJ
cord-264884-ydkigome	353	14	and	and	CC
cord-264884-ydkigome	353	15	mutant	mutant	JJ
cord-264884-ydkigome	353	16	copies	copy	NNS
cord-264884-ydkigome	353	17	.	.	.
cord-264884-ydkigome	354	1	In	in	IN
cord-264884-ydkigome	354	2	this	this	DT
cord-264884-ydkigome	354	3	genomic	genomic	JJ
cord-264884-ydkigome	354	4	colonization	colonization	NN
cord-264884-ydkigome	354	5	they	-PRON-	PRP
cord-264884-ydkigome	354	6	resemble	resemble	VBP
cord-264884-ydkigome	354	7	the	the	DT
cord-264884-ydkigome	354	8	dsDNA	dsdna	JJ
cord-264884-ydkigome	354	9	viruses	virus	NNS
cord-264884-ydkigome	354	10	of	of	IN
cord-264884-ydkigome	354	11	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	354	12	(	(	-LRB-
cord-264884-ydkigome	354	13	discussed	discuss	VBN
cord-264884-ydkigome	354	14	below	below	IN
cord-264884-ydkigome	354	15	)	)	-RRB-
cord-264884-ydkigome	354	16	that	that	WDT
cord-264884-ydkigome	354	17	also	also	RB
cord-264884-ydkigome	354	18	colonize	colonize	VBP
cord-264884-ydkigome	354	19	all	all	DT
cord-264884-ydkigome	354	20	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	354	21	although	although	IN
cord-264884-ydkigome	354	22	at	at	IN
cord-264884-ydkigome	354	23	a	a	DT
cord-264884-ydkigome	354	24	much	much	RB
cord-264884-ydkigome	354	25	lower	low	JJR
cord-264884-ydkigome	354	26	numbers	number	NNS
cord-264884-ydkigome	354	27	.	.	.
cord-264884-ydkigome	355	1	The	the	DT
cord-264884-ydkigome	355	2	human	human	JJ
cord-264884-ydkigome	355	3	genome	genome	NN
cord-264884-ydkigome	355	4	has	have	VBZ
cord-264884-ydkigome	355	5	fewer	few	JJR
cord-264884-ydkigome	355	6	than	than	IN
cord-264884-ydkigome	355	7	26	26	CD
cord-264884-ydkigome	355	8	000	000	CD
cord-264884-ydkigome	355	9	genes	gene	NNS
cord-264884-ydkigome	355	10	,	,	,
cord-264884-ydkigome	355	11	but	but	CC
cord-264884-ydkigome	355	12	appears	appear	VBZ
cord-264884-ydkigome	355	13	to	to	TO
cord-264884-ydkigome	355	14	have	have	VB
cord-264884-ydkigome	355	15	500	500	CD
cord-264884-ydkigome	355	16	000	000	CD
cord-264884-ydkigome	355	17	retroviral	retroviral	NN
cord-264884-ydkigome	355	18	-	-	HYPH
cord-264884-ydkigome	355	19	related	relate	VBN
cord-264884-ydkigome	355	20	LTR	LTR	NNP
cord-264884-ydkigome	355	21	elements	element	NNS
cord-264884-ydkigome	355	22	.	.	.
cord-264884-ydkigome	356	1	Some	some	DT
cord-264884-ydkigome	356	2	of	of	IN
cord-264884-ydkigome	356	3	these	these	DT
cord-264884-ydkigome	356	4	elements	element	NNS
cord-264884-ydkigome	356	5	are	be	VBP
cord-264884-ydkigome	356	6	intact	intact	JJ
cord-264884-ydkigome	356	7	and	and	CC
cord-264884-ydkigome	356	8	conserved	conserved	JJ
cord-264884-ydkigome	356	9	(	(	-LRB-
cord-264884-ydkigome	356	10	human	human	JJ
cord-264884-ydkigome	356	11	ERVs	erv	NNS
cord-264884-ydkigome	356	12	(	(	-LRB-
cord-264884-ydkigome	356	13	HERVs	HERVs	NNP
cord-264884-ydkigome	356	14	)	)	-RRB-
cord-264884-ydkigome	356	15	)	)	-RRB-
cord-264884-ydkigome	356	16	and	and	CC
cord-264884-ydkigome	356	17	this	this	DT
cord-264884-ydkigome	356	18	genomic	genomic	JJ
cord-264884-ydkigome	356	19	population	population	NN
cord-264884-ydkigome	356	20	has	have	VBZ
cord-264884-ydkigome	356	21	some	some	DT
cord-264884-ydkigome	356	22	clear	clear	JJ
cord-264884-ydkigome	356	23	characteristics	characteristic	NNS
cord-264884-ydkigome	356	24	of	of	IN
cord-264884-ydkigome	356	25	a	a	DT
cord-264884-ydkigome	356	26	viral	viral	JJ
cord-264884-ydkigome	356	27	quasispecies	quasispecie	NNS
cord-264884-ydkigome	356	28	.	.	.
cord-264884-ydkigome	357	1	Such	such	JJ
cord-264884-ydkigome	357	2	large	large	JJ
cord-264884-ydkigome	357	3	amounts	amount	NNS
cord-264884-ydkigome	357	4	of	of	IN
cord-264884-ydkigome	357	5	genetic	genetic	JJ
cord-264884-ydkigome	357	6	material	material	NN
cord-264884-ydkigome	357	7	have	have	VBP
cord-264884-ydkigome	357	8	previously	previously	RB
cord-264884-ydkigome	357	9	been	be	VBN
cord-264884-ydkigome	357	10	dismissed	dismiss	VBN
cord-264884-ydkigome	357	11	simply	simply	RB
cord-264884-ydkigome	357	12	as	as	IN
cord-264884-ydkigome	357	13	selfi	selfi	NNP
cord-264884-ydkigome	357	14	sh	sh	NNP
cord-264884-ydkigome	357	15	or	or	CC
cord-264884-ydkigome	357	16	junk	junk	NN
cord-264884-ydkigome	357	17	DNA	dna	NN
cord-264884-ydkigome	357	18	of	of	IN
cord-264884-ydkigome	357	19	no	no	DT
cord-264884-ydkigome	357	20	fi	fi	XX
cord-264884-ydkigome	357	21	tness	tness	NN
cord-264884-ydkigome	357	22	consequences	consequence	NNS
cord-264884-ydkigome	357	23	to	to	IN
cord-264884-ydkigome	357	24	the	the	DT
cord-264884-ydkigome	357	25	host	host	NN
cord-264884-ydkigome	357	26	.	.	.
cord-264884-ydkigome	358	1	However	however	RB
cord-264884-ydkigome	358	2	,	,	,
cord-264884-ydkigome	358	3	given	give	VBN
cord-264884-ydkigome	358	4	the	the	DT
cord-264884-ydkigome	358	5	importance	importance	NN
cord-264884-ydkigome	358	6	of	of	IN
cord-264884-ydkigome	358	7	quasispecies	quasispecie	NNS
cord-264884-ydkigome	358	8	mutant	mutant	JJ
cord-264884-ydkigome	358	9	genomes	genome	NNS
cord-264884-ydkigome	358	10	for	for	IN
cord-264884-ydkigome	358	11	viral	viral	JJ
cord-264884-ydkigome	358	12	fi	fi	NN
cord-264884-ydkigome	358	13	tness	tness	NN
cord-264884-ydkigome	358	14	and	and	CC
cord-264884-ydkigome	358	15	persistence	persistence	NN
cord-264884-ydkigome	358	16	,	,	,
cord-264884-ydkigome	358	17	we	-PRON-	PRP
cord-264884-ydkigome	358	18	might	may	MD
cord-264884-ydkigome	358	19	need	need	VB
cord-264884-ydkigome	358	20	to	to	TO
cord-264884-ydkigome	358	21	re	re	VB
cord-264884-ydkigome	358	22	-	-	VB
cord-264884-ydkigome	358	23	evaluate	evaluate	VB
cord-264884-ydkigome	358	24	this	this	DT
cord-264884-ydkigome	358	25	dismissal	dismissal	NN
cord-264884-ydkigome	358	26	.	.	.
cord-264884-ydkigome	359	1	Retroviruses	retrovirus	NNS
cord-264884-ydkigome	359	2	are	be	VBP
cord-264884-ydkigome	359	3	clearly	clearly	RB
cord-264884-ydkigome	359	4	part	part	NN
cord-264884-ydkigome	359	5	of	of	IN
cord-264884-ydkigome	359	6	the	the	DT
cord-264884-ydkigome	359	7	human	human	JJ
cord-264884-ydkigome	359	8	ancestry	ancestry	NN
cord-264884-ydkigome	359	9	thus	thus	RB
cord-264884-ydkigome	359	10	we	-PRON-	PRP
cord-264884-ydkigome	359	11	should	should	MD
cord-264884-ydkigome	359	12	seek	seek	VB
cord-264884-ydkigome	359	13	to	to	TO
cord-264884-ydkigome	359	14	understand	understand	VB
cord-264884-ydkigome	359	15	,	,	,
cord-264884-ydkigome	359	16	not	not	RB
cord-264884-ydkigome	359	17	dismiss	dismiss	VB
cord-264884-ydkigome	359	18	their	-PRON-	PRP$
cord-264884-ydkigome	359	19	role	role	NN
cord-264884-ydkigome	359	20	in	in	IN
cord-264884-ydkigome	359	21	human	human	JJ
cord-264884-ydkigome	359	22	evolution	evolution	NN
cord-264884-ydkigome	359	23	.	.	.
cord-264884-ydkigome	360	1	In	in	IN
cord-264884-ydkigome	360	2	contrast	contrast	NN
cord-264884-ydkigome	360	3	to	to	IN
cord-264884-ydkigome	360	4	the	the	DT
cord-264884-ydkigome	360	5	story	story	NN
cord-264884-ydkigome	360	6	above	above	RB
cord-264884-ydkigome	360	7	in	in	IN
cord-264884-ydkigome	360	8	which	which	WDT
cord-264884-ydkigome	360	9	polio	polio	NN
cord-264884-ydkigome	360	10	infection	infection	NN
cord-264884-ydkigome	360	11	of	of	IN
cord-264884-ydkigome	360	12	mouse	mouse	NN
cord-264884-ydkigome	360	13	brain	brain	NN
cord-264884-ydkigome	360	14	was	be	VBD
cord-264884-ydkigome	360	15	dependent	dependent	JJ
cord-264884-ydkigome	360	16	on	on	IN
cord-264884-ydkigome	360	17	the	the	DT
cord-264884-ydkigome	360	18	quasispecies	quasispecie	NNS
cord-264884-ydkigome	360	19	resulting	result	VBG
cord-264884-ydkigome	360	20	from	from	IN
cord-264884-ydkigome	360	21	lowered	lower	VBN
cord-264884-ydkigome	360	22	fi	fi	NN
cord-264884-ydkigome	360	23	delity	delity	NN
cord-264884-ydkigome	360	24	replication	replication	NN
cord-264884-ydkigome	360	25	,	,	,
cord-264884-ydkigome	360	26	a	a	DT
cord-264884-ydkigome	360	27	different	different	JJ
cord-264884-ydkigome	360	28	relationship	relationship	NN
cord-264884-ydkigome	360	29	has	have	VBZ
cord-264884-ydkigome	360	30	been	be	VBN
cord-264884-ydkigome	360	31	proposed	propose	VBN
cord-264884-ydkigome	360	32	for	for	IN
cord-264884-ydkigome	360	33	the	the	DT
cord-264884-ydkigome	360	34	nidoviruses	nidoviruse	NNS
cord-264884-ydkigome	360	35	.	.	.
cord-264884-ydkigome	361	1	These	these	DT
cord-264884-ydkigome	361	2	are	be	VBP
cord-264884-ydkigome	361	3	also	also	RB
cord-264884-ydkigome	361	4	positive	positive	JJ
cord-264884-ydkigome	361	5	single	single	JJ
cord-264884-ydkigome	361	6	-	-	HYPH
cord-264884-ydkigome	361	7	stranded	strand	VBN
cord-264884-ydkigome	361	8	polycistronic	polycistronic	NNP
cord-264884-ydkigome	361	9	RNA	RNA	NNP
cord-264884-ydkigome	361	10	viruses	virus	NNS
cord-264884-ydkigome	361	11	(	(	-LRB-
cord-264884-ydkigome	361	12	Gorbalenya	Gorbalenya	NNP
cord-264884-ydkigome	361	13	et	et	NNP
cord-264884-ydkigome	361	14	al	al	NNP
cord-264884-ydkigome	361	15	.	.	NNP
cord-264884-ydkigome	361	16	,	,	,
cord-264884-ydkigome	361	17	2006	2006	CD
cord-264884-ydkigome	361	18	)	)	-RRB-
cord-264884-ydkigome	361	19	.	.	.
cord-264884-ydkigome	362	1	This	this	DT
cord-264884-ydkigome	362	2	group	group	NN
cord-264884-ydkigome	362	3	of	of	IN
cord-264884-ydkigome	362	4	virus	virus	NN
cord-264884-ydkigome	362	5	includes	include	VBZ
cord-264884-ydkigome	362	6	the	the	DT
cord-264884-ydkigome	362	7	coronaviruses	coronaviruse	NNS
cord-264884-ydkigome	362	8	(	(	-LRB-
cord-264884-ydkigome	362	9	e.g.	e.g.	IN
cord-264884-ydkigome	362	10	mouse	mouse	NNP
cord-264884-ydkigome	362	11	hepatitis	hepatitis	NNP
cord-264884-ydkigome	362	12	virus	virus	NN
cord-264884-ydkigome	362	13	and	and	CC
cord-264884-ydkigome	362	14	SARS	SARS	NNP
cord-264884-ydkigome	362	15	-	-	HYPH
cord-264884-ydkigome	362	16	associated	associate	VBN
cord-264884-ydkigome	362	17	coronavirus	coronavirus	NN
cord-264884-ydkigome	362	18	)	)	-RRB-
cord-264884-ydkigome	362	19	,	,	,
cord-264884-ydkigome	362	20	which	which	WDT
cord-264884-ydkigome	362	21	are	be	VBP
cord-264884-ydkigome	362	22	the	the	DT
cord-264884-ydkigome	362	23	largest	large	JJS
cord-264884-ydkigome	362	24	RNA	rna	NN
cord-264884-ydkigome	362	25	viruses	virus	NNS
cord-264884-ydkigome	362	26	known	know	VBN
cord-264884-ydkigome	362	27	(	(	-LRB-
cord-264884-ydkigome	362	28	26	26	CD
cord-264884-ydkigome	362	29	-	-	SYM
cord-264884-ydkigome	362	30	32	32	CD
cord-264884-ydkigome	362	31	kb	kb	NNP
cord-264884-ydkigome	362	32	)	)	-RRB-
cord-264884-ydkigome	362	33	.	.	.
cord-264884-ydkigome	363	1	It	-PRON-	PRP
cord-264884-ydkigome	363	2	has	have	VBZ
cord-264884-ydkigome	363	3	been	be	VBN
cord-264884-ydkigome	363	4	proposed	propose	VBN
cord-264884-ydkigome	363	5	that	that	IN
cord-264884-ydkigome	363	6	such	such	JJ
cord-264884-ydkigome	363	7	large	large	JJ
cord-264884-ydkigome	363	8	genomes	genome	NNS
cord-264884-ydkigome	363	9	have	have	VBP
cord-264884-ydkigome	363	10	required	require	VBN
cord-264884-ydkigome	363	11	the	the	DT
cord-264884-ydkigome	363	12	adaptation	adaptation	NN
cord-264884-ydkigome	363	13	of	of	IN
cord-264884-ydkigome	363	14	a	a	DT
cord-264884-ydkigome	363	15	high	high	JJ
cord-264884-ydkigome	363	16	-	-	HYPH
cord-264884-ydkigome	363	17	fi	fi	NN
cord-264884-ydkigome	363	18	delity	delity	NN
cord-264884-ydkigome	363	19	RNA	RNA	NNP
cord-264884-ydkigome	363	20	polymerase	polymerase	NN
cord-264884-ydkigome	363	21	in	in	IN
cord-264884-ydkigome	363	22	order	order	NN
cord-264884-ydkigome	363	23	to	to	TO
cord-264884-ydkigome	363	24	increase	increase	VB
cord-264884-ydkigome	363	25	the	the	DT
cord-264884-ydkigome	363	26	error	error	NN
cord-264884-ydkigome	363	27	threshold	threshold	NN
cord-264884-ydkigome	363	28	and	and	CC
cord-264884-ydkigome	363	29	accommodate	accommodate	VB
cord-264884-ydkigome	363	30	large	large	JJ
cord-264884-ydkigome	363	31	RNA	RNA	NNP
cord-264884-ydkigome	363	32	genomes	genome	NNS
cord-264884-ydkigome	363	33	.	.	.
cord-264884-ydkigome	364	1	Based	base	VBN
cord-264884-ydkigome	364	2	on	on	IN
cord-264884-ydkigome	364	3	the	the	DT
cord-264884-ydkigome	364	4	phylogenetics	phylogenetic	NNS
cord-264884-ydkigome	364	5	of	of	IN
cord-264884-ydkigome	364	6	this	this	DT
cord-264884-ydkigome	364	7	polymerase	polymerase	NN
cord-264884-ydkigome	364	8	and	and	CC
cord-264884-ydkigome	364	9	other	other	JJ
cord-264884-ydkigome	364	10	RNA	rna	NN
cord-264884-ydkigome	364	11	-	-	HYPH
cord-264884-ydkigome	364	12	processing	processing	NN
cord-264884-ydkigome	364	13	enzymes	enzyme	NNS
cord-264884-ydkigome	364	14	,	,	,
cord-264884-ydkigome	364	15	this	this	DT
cord-264884-ydkigome	364	16	group	group	NN
cord-264884-ydkigome	364	17	of	of	IN
cord-264884-ydkigome	364	18	viruses	virus	NNS
cord-264884-ydkigome	364	19	appears	appear	VBZ
cord-264884-ydkigome	364	20	to	to	TO
cord-264884-ydkigome	364	21	be	be	VB
cord-264884-ydkigome	364	22	monophyletic	monophyletic	JJ
cord-264884-ydkigome	364	23	and	and	CC
cord-264884-ydkigome	364	24	it	-PRON-	PRP
cord-264884-ydkigome	364	25	is	be	VBZ
cord-264884-ydkigome	364	26	thought	think	VBN
cord-264884-ydkigome	364	27	that	that	IN
cord-264884-ydkigome	364	28	the	the	DT
cord-264884-ydkigome	364	29	acquisition	acquisition	NN
cord-264884-ydkigome	364	30	of	of	IN
cord-264884-ydkigome	364	31	a	a	DT
cord-264884-ydkigome	364	32	high	high	JJ
cord-264884-ydkigome	364	33	-	-	HYPH
cord-264884-ydkigome	364	34	fi	fi	NN
cord-264884-ydkigome	364	35	delity	delity	NNP
cord-264884-ydkigome	364	36	RNA	RNA	NNP
cord-264884-ydkigome	364	37	replicase	replicase	NN
cord-264884-ydkigome	364	38	was	be	VBD
cord-264884-ydkigome	364	39	central	central	JJ
cord-264884-ydkigome	364	40	to	to	IN
cord-264884-ydkigome	364	41	the	the	DT
cord-264884-ydkigome	364	42	origin	origin	NN
cord-264884-ydkigome	364	43	of	of	IN
cord-264884-ydkigome	364	44	this	this	DT
cord-264884-ydkigome	364	45	lineage	lineage	NN
cord-264884-ydkigome	364	46	.	.	.
cord-264884-ydkigome	365	1	This	this	DT
cord-264884-ydkigome	365	2	type	type	NN
cord-264884-ydkigome	365	3	of	of	IN
cord-264884-ydkigome	365	4	replicase	replicase	NN
cord-264884-ydkigome	365	5	is	be	VBZ
cord-264884-ydkigome	365	6	unique	unique	JJ
cord-264884-ydkigome	365	7	to	to	IN
cord-264884-ydkigome	365	8	RNA	RNA	NNP
cord-264884-ydkigome	365	9	viruses	virus	NNS
cord-264884-ydkigome	365	10	.	.	.
cord-264884-ydkigome	366	1	The	the	DT
cord-264884-ydkigome	366	2	monophyletic	monophyletic	JJ
cord-264884-ydkigome	366	3	view	view	NN
cord-264884-ydkigome	366	4	stems	stem	VBZ
cord-264884-ydkigome	366	5	from	from	IN
cord-264884-ydkigome	366	6	an	an	DT
cord-264884-ydkigome	366	7	analysis	analysis	NN
cord-264884-ydkigome	366	8	of	of	IN
cord-264884-ydkigome	366	9	a	a	DT
cord-264884-ydkigome	366	10	small	small	JJ
cord-264884-ydkigome	366	11	set	set	NN
cord-264884-ydkigome	366	12	of	of	IN
cord-264884-ydkigome	366	13	conserved	conserved	JJ
cord-264884-ydkigome	366	14	genes	gene	NNS
cord-264884-ydkigome	366	15	.	.	.
cord-264884-ydkigome	367	1	Overall	overall	RB
cord-264884-ydkigome	367	2	,	,	,
cord-264884-ydkigome	367	3	however	however	RB
cord-264884-ydkigome	367	4	,	,	,
cord-264884-ydkigome	367	5	these	these	DT
cord-264884-ydkigome	367	6	larger	large	JJR
cord-264884-ydkigome	367	7	genomes	genome	NNS
cord-264884-ydkigome	367	8	have	have	VBP
cord-264884-ydkigome	367	9	many	many	JJ
cord-264884-ydkigome	367	10	other	other	JJ
cord-264884-ydkigome	367	11	genes	gene	NNS
cord-264884-ydkigome	367	12	that	that	WDT
cord-264884-ydkigome	367	13	show	show	VBP
cord-264884-ydkigome	367	14	no	no	DT
cord-264884-ydkigome	367	15	similarities	similarity	NNS
cord-264884-ydkigome	367	16	to	to	IN
cord-264884-ydkigome	367	17	related	related	JJ
cord-264884-ydkigome	367	18	viruses	virus	NNS
cord-264884-ydkigome	367	19	.	.	.
cord-264884-ydkigome	368	1	The	the	DT
cord-264884-ydkigome	368	2	origins	origin	NNS
cord-264884-ydkigome	368	3	and	and	CC
cord-264884-ydkigome	368	4	evolution	evolution	NN
cord-264884-ydkigome	368	5	of	of	IN
cord-264884-ydkigome	368	6	these	these	DT
cord-264884-ydkigome	368	7	more	more	RBR
cord-264884-ydkigome	368	8	diverse	diverse	JJ
cord-264884-ydkigome	368	9	and	and	CC
cord-264884-ydkigome	368	10	numerous	numerous	JJ
cord-264884-ydkigome	368	11	genes	gene	NNS
cord-264884-ydkigome	368	12	can	can	MD
cord-264884-ydkigome	368	13	not	not	RB
cord-264884-ydkigome	368	14	be	be	VB
cord-264884-ydkigome	368	15	currently	currently	RB
cord-264884-ydkigome	368	16	traced	trace	VBN
cord-264884-ydkigome	368	17	.	.	.
cord-264884-ydkigome	369	1	This	this	DT
cord-264884-ydkigome	369	2	is	be	VBZ
cord-264884-ydkigome	369	3	an	an	DT
cord-264884-ydkigome	369	4	inherent	inherent	JJ
cord-264884-ydkigome	369	5	problem	problem	NN
cord-264884-ydkigome	369	6	in	in	IN
cord-264884-ydkigome	369	7	the	the	DT
cord-264884-ydkigome	369	8	analysis	analysis	NN
cord-264884-ydkigome	369	9	of	of	IN
cord-264884-ydkigome	369	10	virus	virus	NN
cord-264884-ydkigome	369	11	evolution	evolution	NN
cord-264884-ydkigome	369	12	:	:	:
cord-264884-ydkigome	369	13	a	a	DT
cord-264884-ydkigome	369	14	small	small	JJ
cord-264884-ydkigome	369	15	selected	select	VBN
cord-264884-ydkigome	369	16	set	set	NN
cord-264884-ydkigome	369	17	of	of	IN
cord-264884-ydkigome	369	18	hallmark	hallmark	JJ
cord-264884-ydkigome	369	19	genes	gene	NNS
cord-264884-ydkigome	369	20	with	with	IN
cord-264884-ydkigome	369	21	some	some	DT
cord-264884-ydkigome	369	22	similarity	similarity	NN
cord-264884-ydkigome	369	23	are	be	VBP
cord-264884-ydkigome	369	24	assumed	assume	VBN
cord-264884-ydkigome	369	25	to	to	TO
cord-264884-ydkigome	369	26	trace	trace	VB
cord-264884-ydkigome	369	27	an	an	DT
cord-264884-ydkigome	369	28	apparently	apparently	RB
cord-264884-ydkigome	369	29	linear	linear	JJ
cord-264884-ydkigome	369	30	(	(	-LRB-
cord-264884-ydkigome	369	31	tree	tree	NN
cord-264884-ydkigome	369	32	-	-	HYPH
cord-264884-ydkigome	369	33	based	base	VBN
cord-264884-ydkigome	369	34	)	)	-RRB-
cord-264884-ydkigome	369	35	viral	viral	JJ
cord-264884-ydkigome	369	36	lineage	lineage	NN
cord-264884-ydkigome	369	37	whereas	whereas	IN
cord-264884-ydkigome	369	38	the	the	DT
cord-264884-ydkigome	369	39	larger	large	JJR
cord-264884-ydkigome	369	40	number	number	NN
cord-264884-ydkigome	369	41	of	of	IN
cord-264884-ydkigome	369	42	genes	gene	NNS
cord-264884-ydkigome	369	43	are	be	VBP
cord-264884-ydkigome	369	44	not	not	RB
cord-264884-ydkigome	369	45	included	include	VBN
cord-264884-ydkigome	369	46	and	and	CC
cord-264884-ydkigome	369	47	can	can	MD
cord-264884-ydkigome	369	48	not	not	RB
cord-264884-ydkigome	369	49	be	be	VB
cord-264884-ydkigome	369	50	traced	trace	VBN
cord-264884-ydkigome	369	51	.	.	.
cord-264884-ydkigome	370	1	If	if	IN
cord-264884-ydkigome	370	2	most	most	JJS
cord-264884-ydkigome	370	3	of	of	IN
cord-264884-ydkigome	370	4	RNA	RNA	NNP
cord-264884-ydkigome	370	5	virus	virus	NN
cord-264884-ydkigome	370	6	evolution	evolution	NN
cord-264884-ydkigome	370	7	is	be	VBZ
cord-264884-ydkigome	370	8	indeed	indeed	RB
cord-264884-ydkigome	370	9	mediated	mediate	VBN
cord-264884-ydkigome	370	10	by	by	IN
cord-264884-ydkigome	370	11	a	a	DT
cord-264884-ydkigome	370	12	mixed	mixed	JJ
cord-264884-ydkigome	370	13	cloud	cloud	NN
cord-264884-ydkigome	370	14	of	of	IN
cord-264884-ydkigome	370	15	genomes	genome	NNS
cord-264884-ydkigome	370	16	,	,	,
cord-264884-ydkigome	370	17	any	any	DT
cord-264884-ydkigome	370	18	role	role	NN
cord-264884-ydkigome	370	19	for	for	IN
cord-264884-ydkigome	370	20	mutant	mutant	JJ
cord-264884-ydkigome	370	21	mixtures	mixture	NNS
cord-264884-ydkigome	370	22	thus	thus	RB
cord-264884-ydkigome	370	23	becomes	become	VBZ
cord-264884-ydkigome	370	24	obscure	obscure	JJ
cord-264884-ydkigome	370	25	.	.	.
cord-264884-ydkigome	371	1	But	but	CC
cord-264884-ydkigome	371	2	perhaps	perhaps	RB
cord-264884-ydkigome	371	3	there	there	EX
cord-264884-ydkigome	371	4	is	be	VBZ
cord-264884-ydkigome	371	5	little	little	JJ
cord-264884-ydkigome	371	6	else	else	RB
cord-264884-ydkigome	371	7	we	-PRON-	PRP
cord-264884-ydkigome	371	8	can	can	MD
cord-264884-ydkigome	371	9	currently	currently	RB
cord-264884-ydkigome	371	10	do	do	VB
cord-264884-ydkigome	371	11	given	give	VBN
cord-264884-ydkigome	371	12	the	the	DT
cord-264884-ydkigome	371	13	lack	lack	NN
cord-264884-ydkigome	371	14	of	of	IN
cord-264884-ydkigome	371	15	information	information	NN
cord-264884-ydkigome	371	16	.	.	.
cord-264884-ydkigome	372	1	How	how	WRB
cord-264884-ydkigome	372	2	might	may	MD
cord-264884-ydkigome	372	3	we	-PRON-	PRP
cord-264884-ydkigome	372	4	explain	explain	VB
cord-264884-ydkigome	372	5	the	the	DT
cord-264884-ydkigome	372	6	increased	increase	VBN
cord-264884-ydkigome	372	7	fi	fi	NN
cord-264884-ydkigome	372	8	delity	delity	NN
cord-264884-ydkigome	372	9	and	and	CC
cord-264884-ydkigome	372	10	genome	genome	NN
cord-264884-ydkigome	372	11	size	size	NN
cord-264884-ydkigome	372	12	of	of	IN
cord-264884-ydkigome	372	13	the	the	DT
cord-264884-ydkigome	372	14	nidoviruses	nidoviruse	NNS
cord-264884-ydkigome	372	15	?	?	.
cord-264884-ydkigome	373	1	Was	be	VBD
cord-264884-ydkigome	373	2	there	there	EX
cord-264884-ydkigome	373	3	some	some	DT
cord-264884-ydkigome	373	4	change	change	NN
cord-264884-ydkigome	373	5	in	in	IN
cord-264884-ydkigome	373	6	viral	viral	JJ
cord-264884-ydkigome	373	7	adaptation	adaptation	NN
cord-264884-ydkigome	373	8	in	in	IN
cord-264884-ydkigome	373	9	which	which	WDT
cord-264884-ydkigome	373	10	quasispecies	quasispecie	NNS
cord-264884-ydkigome	373	11	and	and	CC
cord-264884-ydkigome	373	12	generation	generation	NN
cord-264884-ydkigome	373	13	of	of	IN
cord-264884-ydkigome	373	14	mixtures	mixture	NNS
cord-264884-ydkigome	373	15	was	be	VBD
cord-264884-ydkigome	373	16	no	no	RB
cord-264884-ydkigome	373	17	longer	long	RBR
cord-264884-ydkigome	373	18	as	as	IN
cord-264884-ydkigome	373	19	important	important	JJ
cord-264884-ydkigome	373	20	for	for	IN
cord-264884-ydkigome	373	21	adaptation	adaptation	NN
cord-264884-ydkigome	373	22	?	?	.
cord-264884-ydkigome	374	1	Did	do	VBD
cord-264884-ydkigome	374	2	the	the	DT
cord-264884-ydkigome	374	3	need	need	NN
cord-264884-ydkigome	374	4	and	and	CC
cord-264884-ydkigome	374	5	selection	selection	NN
cord-264884-ydkigome	374	6	for	for	IN
cord-264884-ydkigome	374	7	a	a	DT
cord-264884-ydkigome	374	8	larger	large	JJR
cord-264884-ydkigome	374	9	genome	genome	NN
cord-264884-ydkigome	374	10	override	override	VBP
cord-264884-ydkigome	374	11	the	the	DT
cord-264884-ydkigome	374	12	use	use	NN
cord-264884-ydkigome	374	13	of	of	IN
cord-264884-ydkigome	374	14	error	error	NN
cord-264884-ydkigome	374	15	to	to	TO
cord-264884-ydkigome	374	16	generate	generate	VB
cord-264884-ydkigome	374	17	adaptability	adaptability	NN
cord-264884-ydkigome	374	18	as	as	IN
cord-264884-ydkigome	374	19	seen	see	VBN
cord-264884-ydkigome	374	20	in	in	IN
cord-264884-ydkigome	374	21	poliovirus	poliovirus	NN
cord-264884-ydkigome	374	22	and	and	CC
cord-264884-ydkigome	374	23	HIV-1	HIV-1	NNP
cord-264884-ydkigome	374	24	?	?	.
cord-264884-ydkigome	375	1	If	if	IN
cord-264884-ydkigome	375	2	so	so	RB
cord-264884-ydkigome	375	3	,	,	,
cord-264884-ydkigome	375	4	what	what	WDT
cord-264884-ydkigome	375	5	selective	selective	JJ
cord-264884-ydkigome	375	6	pressures	pressure	NNS
cord-264884-ydkigome	375	7	might	may	MD
cord-264884-ydkigome	375	8	have	have	VB
cord-264884-ydkigome	375	9	changed	change	VBN
cord-264884-ydkigome	375	10	this	this	DT
cord-264884-ydkigome	375	11	seemingly	seemingly	RB
cord-264884-ydkigome	375	12	basic	basic	JJ
cord-264884-ydkigome	375	13	feature	feature	NN
cord-264884-ydkigome	375	14	?	?	.
cord-264884-ydkigome	376	1	What	what	WP
cord-264884-ydkigome	376	2	do	do	VBP
cord-264884-ydkigome	376	3	we	-PRON-	PRP
cord-264884-ydkigome	376	4	know	know	VB
cord-264884-ydkigome	376	5	about	about	IN
cord-264884-ydkigome	376	6	the	the	DT
cord-264884-ydkigome	376	7	natural	natural	JJ
cord-264884-ydkigome	376	8	biology	biology	NN
cord-264884-ydkigome	376	9	of	of	IN
cord-264884-ydkigome	376	10	these	these	DT
cord-264884-ydkigome	376	11	viruses	virus	NNS
cord-264884-ydkigome	376	12	,	,	,
cord-264884-ydkigome	376	13	which	which	WDT
cord-264884-ydkigome	376	14	might	may	MD
cord-264884-ydkigome	376	15	provide	provide	VB
cord-264884-ydkigome	376	16	some	some	DT
cord-264884-ydkigome	376	17	insight	insight	NN
cord-264884-ydkigome	376	18	into	into	IN
cord-264884-ydkigome	376	19	this	this	DT
cord-264884-ydkigome	376	20	?	?	.
cord-264884-ydkigome	377	1	Unfortunately	unfortunately	RB
cord-264884-ydkigome	377	2	,	,	,
cord-264884-ydkigome	377	3	the	the	DT
cord-264884-ydkigome	377	4	natural	natural	JJ
cord-264884-ydkigome	377	5	distribution	distribution	NN
cord-264884-ydkigome	377	6	and	and	CC
cord-264884-ydkigome	377	7	gene	gene	NN
cord-264884-ydkigome	377	8	functions	function	NNS
cord-264884-ydkigome	377	9	of	of	IN
cord-264884-ydkigome	377	10	the	the	DT
cord-264884-ydkigome	377	11	nidoviruses	nidoviruse	NNS
cord-264884-ydkigome	377	12	are	be	VBP
cord-264884-ydkigome	377	13	generally	generally	RB
cord-264884-ydkigome	377	14	poorly	poorly	RB
cord-264884-ydkigome	377	15	understood	understand	VBN
cord-264884-ydkigome	377	16	.	.	.
cord-264884-ydkigome	378	1	In	in	IN
cord-264884-ydkigome	378	2	terms	term	NNS
cord-264884-ydkigome	378	3	of	of	IN
cord-264884-ydkigome	378	4	coronaviruses	coronaviruse	NNS
cord-264884-ydkigome	378	5	,	,	,
cord-264884-ydkigome	378	6	numerous	numerous	JJ
cord-264884-ydkigome	378	7	mammal	mammal	NN
cord-264884-ydkigome	378	8	and	and	CC
cord-264884-ydkigome	378	9	avian	avian	JJ
cord-264884-ydkigome	378	10	species	specie	NNS
cord-264884-ydkigome	378	11	can	can	MD
cord-264884-ydkigome	378	12	be	be	VB
cord-264884-ydkigome	378	13	infected	infect	VBN
cord-264884-ydkigome	378	14	and	and	CC
cord-264884-ydkigome	378	15	the	the	DT
cord-264884-ydkigome	378	16	virus	virus	NN
cord-264884-ydkigome	378	17	will	will	MD
cord-264884-ydkigome	378	18	cause	cause	VB
cord-264884-ydkigome	378	19	acute	acute	JJ
cord-264884-ydkigome	378	20	disease	disease	NN
cord-264884-ydkigome	378	21	.	.	.
cord-264884-ydkigome	379	1	In	in	IN
cord-264884-ydkigome	379	2	several	several	JJ
cord-264884-ydkigome	379	3	of	of	IN
cord-264884-ydkigome	379	4	these	these	DT
cord-264884-ydkigome	379	5	acute	acute	JJ
cord-264884-ydkigome	379	6	infections	infection	NNS
cord-264884-ydkigome	379	7	,	,	,
cord-264884-ydkigome	379	8	the	the	DT
cord-264884-ydkigome	379	9	virus	virus	NN
cord-264884-ydkigome	379	10	involved	involve	VBN
cord-264884-ydkigome	379	11	seems	seem	VBZ
cord-264884-ydkigome	379	12	to	to	TO
cord-264884-ydkigome	379	13	have	have	VB
cord-264884-ydkigome	379	14	recently	recently	RB
cord-264884-ydkigome	379	15	been	be	VBN
cord-264884-ydkigome	379	16	adapted	adapt	VBN
cord-264884-ydkigome	379	17	to	to	IN
cord-264884-ydkigome	379	18	the	the	DT
cord-264884-ydkigome	379	19	new	new	JJ
cord-264884-ydkigome	379	20	host	host	NN
cord-264884-ydkigome	379	21	from	from	IN
cord-264884-ydkigome	379	22	other	other	JJ
cord-264884-ydkigome	379	23	,	,	,
cord-264884-ydkigome	379	24	often	often	RB
cord-264884-ydkigome	379	25	unknown	unknown	JJ
cord-264884-ydkigome	379	26	sources	source	NNS
cord-264884-ydkigome	379	27	.	.	.
cord-264884-ydkigome	380	1	With	with	IN
cord-264884-ydkigome	380	2	the	the	DT
cord-264884-ydkigome	380	3	recent	recent	JJ
cord-264884-ydkigome	380	4	emergence	emergence	NN
cord-264884-ydkigome	380	5	of	of	IN
cord-264884-ydkigome	380	6	the	the	DT
cord-264884-ydkigome	380	7	SARS	SARS	NNP
cord-264884-ydkigome	380	8	virus	virus	NN
cord-264884-ydkigome	380	9	and	and	CC
cord-264884-ydkigome	380	10	human	human	JJ
cord-264884-ydkigome	380	11	infections	infection	NNS
cord-264884-ydkigome	380	12	,	,	,
cord-264884-ydkigome	380	13	however	however	RB
cord-264884-ydkigome	380	14	,	,	,
cord-264884-ydkigome	380	15	much	much	RB
cord-264884-ydkigome	380	16	greater	great	JJR
cord-264884-ydkigome	380	17	attention	attention	NN
cord-264884-ydkigome	380	18	has	have	VBZ
cord-264884-ydkigome	380	19	been	be	VBN
cord-264884-ydkigome	380	20	focussed	focusse	VBN
cord-264884-ydkigome	380	21	on	on	IN
cord-264884-ydkigome	380	22	trying	try	VBG
cord-264884-ydkigome	380	23	to	to	TO
cord-264884-ydkigome	380	24	understand	understand	VB
cord-264884-ydkigome	380	25	the	the	DT
cord-264884-ydkigome	380	26	origin	origin	NN
cord-264884-ydkigome	380	27	and	and	CC
cord-264884-ydkigome	380	28	evolution	evolution	NN
cord-264884-ydkigome	380	29	of	of	IN
cord-264884-ydkigome	380	30	this	this	DT
cord-264884-ydkigome	380	31	virus	virus	NN
cord-264884-ydkigome	380	32	.	.	.
cord-264884-ydkigome	381	1	It	-PRON-	PRP
cord-264884-ydkigome	381	2	has	have	VBZ
cord-264884-ydkigome	381	3	recently	recently	RB
cord-264884-ydkigome	381	4	become	become	VBN
cord-264884-ydkigome	381	5	clear	clear	JJ
cord-264884-ydkigome	381	6	that	that	IN
cord-264884-ydkigome	381	7	there	there	EX
cord-264884-ydkigome	381	8	indeed	indeed	RB
cord-264884-ydkigome	381	9	appears	appear	VBZ
cord-264884-ydkigome	381	10	to	to	TO
cord-264884-ydkigome	381	11	exist	exist	VB
cord-264884-ydkigome	381	12	an	an	DT
cord-264884-ydkigome	381	13	evolutionary	evolutionary	JJ
cord-264884-ydkigome	381	14	stable	stable	JJ
cord-264884-ydkigome	381	15	source	source	NN
cord-264884-ydkigome	381	16	of	of	IN
cord-264884-ydkigome	381	17	this	this	DT
cord-264884-ydkigome	381	18	virus	virus	NN
cord-264884-ydkigome	381	19	from	from	IN
cord-264884-ydkigome	381	20	which	which	WDT
cord-264884-ydkigome	381	21	adaptation	adaptation	NN
cord-264884-ydkigome	381	22	to	to	IN
cord-264884-ydkigome	381	23	humans	human	NNS
cord-264884-ydkigome	381	24	was	be	VBD
cord-264884-ydkigome	381	25	possible	possible	JJ
cord-264884-ydkigome	381	26	.	.	.
cord-264884-ydkigome	382	1	Various	various	JJ
cord-264884-ydkigome	382	2	bat	bat	NN
cord-264884-ydkigome	382	3	species	specie	NNS
cord-264884-ydkigome	382	4	have	have	VBP
cord-264884-ydkigome	382	5	been	be	VBN
cord-264884-ydkigome	382	6	found	find	VBN
cord-264884-ydkigome	382	7	to	to	TO
cord-264884-ydkigome	382	8	support	support	VB
cord-264884-ydkigome	382	9	persistent	persistent	JJ
cord-264884-ydkigome	382	10	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	382	11	infections	infection	NNS
cord-264884-ydkigome	382	12	by	by	IN
cord-264884-ydkigome	382	13	specifi	specifi	NNP
cord-264884-ydkigome	382	14	c	c	NN
cord-264884-ydkigome	382	15	versions	version	NNS
cord-264884-ydkigome	382	16	of	of	IN
cord-264884-ydkigome	382	17	SARS	SARS	NNP
cord-264884-ydkigome	382	18	viruses	virus	NNS
cord-264884-ydkigome	383	1	(	(	-LRB-
cord-264884-ydkigome	383	2	Tang	Tang	NNP
cord-264884-ydkigome	383	3	et	et	FW
cord-264884-ydkigome	383	4	al	al	NNP
cord-264884-ydkigome	383	5	.	.	NNP
cord-264884-ydkigome	383	6	,	,	,
cord-264884-ydkigome	383	7	2006	2006	CD
cord-264884-ydkigome	383	8	;	;	.
cord-264884-ydkigome	384	1	Vijaykrishna	Vijaykrishna	NNP
cord-264884-ydkigome	384	2	et	et	NNP
cord-264884-ydkigome	384	3	al	al	NNP
cord-264884-ydkigome	384	4	.	.	NNP
cord-264884-ydkigome	384	5	,	,	,
cord-264884-ydkigome	384	6	2007	2007	CD
cord-264884-ydkigome	384	7	)	)	-RRB-
cord-264884-ydkigome	384	8	.	.	.
cord-264884-ydkigome	385	1	These	these	DT
cord-264884-ydkigome	385	2	studies	study	NNS
cord-264884-ydkigome	385	3	also	also	RB
cord-264884-ydkigome	385	4	indicate	indicate	VBP
cord-264884-ydkigome	385	5	that	that	IN
cord-264884-ydkigome	385	6	there	there	EX
cord-264884-ydkigome	385	7	appear	appear	VBP
cord-264884-ydkigome	385	8	to	to	TO
cord-264884-ydkigome	385	9	be	be	VB
cord-264884-ydkigome	385	10	three	three	CD
cord-264884-ydkigome	385	11	different	different	JJ
cord-264884-ydkigome	385	12	and	and	CC
cord-264884-ydkigome	385	13	independent	independent	JJ
cord-264884-ydkigome	385	14	groups	group	NNS
cord-264884-ydkigome	385	15	of	of	IN
cord-264884-ydkigome	385	16	SARS	SARS	NNP
cord-264884-ydkigome	385	17	viruses	virus	NNS
cord-264884-ydkigome	385	18	in	in	IN
cord-264884-ydkigome	385	19	bats	bat	NNS
cord-264884-ydkigome	385	20	.	.	.
cord-264884-ydkigome	386	1	In	in	IN
cord-264884-ydkigome	386	2	fact	fact	NN
cord-264884-ydkigome	386	3	six	six	CD
cord-264884-ydkigome	386	4	novel	novel	NN
cord-264884-ydkigome	386	5	coronaviruses	coronaviruse	NNS
cord-264884-ydkigome	386	6	were	be	VBD
cord-264884-ydkigome	386	7	isolated	isolate	VBN
cord-264884-ydkigome	386	8	from	from	IN
cord-264884-ydkigome	386	9	six	six	CD
cord-264884-ydkigome	386	10	different	different	JJ
cord-264884-ydkigome	386	11	bat	bat	NN
cord-264884-ydkigome	386	12	species	specie	NNS
cord-264884-ydkigome	386	13	showing	show	VBG
cord-264884-ydkigome	386	14	an	an	DT
cord-264884-ydkigome	386	15	astonishing	astonishing	JJ
cord-264884-ydkigome	386	16	diversity	diversity	NN
cord-264884-ydkigome	386	17	in	in	IN
cord-264884-ydkigome	386	18	bats	bat	NNS
cord-264884-ydkigome	386	19	.	.	.
cord-264884-ydkigome	387	1	Furthermore	furthermore	RB
cord-264884-ydkigome	387	2	,	,	,
cord-264884-ydkigome	387	3	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	387	4	analysis	analysis	NN
cord-264884-ydkigome	387	5	indicates	indicate	VBZ
cord-264884-ydkigome	387	6	that	that	IN
cord-264884-ydkigome	387	7	all	all	DT
cord-264884-ydkigome	387	8	bat	bat	NN
cord-264884-ydkigome	387	9	coronaviruses	coronaviruse	NNS
cord-264884-ydkigome	387	10	appear	appear	VBP
cord-264884-ydkigome	387	11	to	to	TO
cord-264884-ydkigome	387	12	have	have	VB
cord-264884-ydkigome	387	13	descended	descend	VBN
cord-264884-ydkigome	387	14	from	from	IN
cord-264884-ydkigome	387	15	a	a	DT
cord-264884-ydkigome	387	16	common	common	JJ
cord-264884-ydkigome	387	17	ancestor	ancestor	NN
cord-264884-ydkigome	387	18	.	.	.
cord-264884-ydkigome	388	1	Only	only	RB
cord-264884-ydkigome	388	2	one	one	CD
cord-264884-ydkigome	388	3	of	of	IN
cord-264884-ydkigome	388	4	these	these	DT
cord-264884-ydkigome	388	5	bat	bat	NN
cord-264884-ydkigome	388	6	groups	group	NNS
cord-264884-ydkigome	388	7	includes	include	VBZ
cord-264884-ydkigome	388	8	SARS	SARS	NNP
cord-264884-ydkigome	388	9	and	and	CC
cord-264884-ydkigome	388	10	SARS	SARS	NNP
cord-264884-ydkigome	388	11	-	-	HYPH
cord-264884-ydkigome	388	12	like	like	JJ
cord-264884-ydkigome	388	13	coronaviruses	coronaviruse	NNS
cord-264884-ydkigome	388	14	that	that	WDT
cord-264884-ydkigome	388	15	adapted	adapt	VBD
cord-264884-ydkigome	388	16	to	to	IN
cord-264884-ydkigome	388	17	acute	acute	JJ
cord-264884-ydkigome	388	18	human	human	JJ
cord-264884-ydkigome	388	19	infections	infection	NNS
cord-264884-ydkigome	388	20	.	.	.
cord-264884-ydkigome	389	1	Thus	thus	RB
cord-264884-ydkigome	389	2	,	,	,
cord-264884-ydkigome	389	3	a	a	DT
cord-264884-ydkigome	389	4	prevalent	prevalent	JJ
cord-264884-ydkigome	389	5	and	and	CC
cord-264884-ydkigome	389	6	speciesspecifi	speciesspecifi	NNP
cord-264884-ydkigome	389	7	c	c	NN
cord-264884-ydkigome	389	8	persistence	persistence	NN
cord-264884-ydkigome	389	9	of	of	IN
cord-264884-ydkigome	389	10	SARS	SARS	NNP
cord-264884-ydkigome	389	11	viruses	virus	NNS
cord-264884-ydkigome	389	12	is	be	VBZ
cord-264884-ydkigome	389	13	found	find	VBN
cord-264884-ydkigome	389	14	in	in	IN
cord-264884-ydkigome	389	15	particular	particular	JJ
cord-264884-ydkigome	389	16	geographical	geographical	JJ
cord-264884-ydkigome	389	17	populations	population	NNS
cord-264884-ydkigome	389	18	.	.	.
cord-264884-ydkigome	390	1	Why	why	WRB
cord-264884-ydkigome	390	2	is	be	VBZ
cord-264884-ydkigome	390	3	this	this	DT
cord-264884-ydkigome	390	4	relationship	relationship	NN
cord-264884-ydkigome	390	5	stable	stable	JJ
cord-264884-ydkigome	390	6	?	?	.
cord-264884-ydkigome	391	1	Could	Could	MD
cord-264884-ydkigome	391	2	the	the	DT
cord-264884-ydkigome	391	3	adaptation	adaptation	NN
cord-264884-ydkigome	391	4	to	to	IN
cord-264884-ydkigome	391	5	a	a	DT
cord-264884-ydkigome	391	6	host	host	NN
cord-264884-ydkigome	391	7	-	-	HYPH
cord-264884-ydkigome	391	8	specifi	specifi	VBN
cord-264884-ydkigome	391	9	c	c	NN
cord-264884-ydkigome	391	10	persistence	persistence	NN
cord-264884-ydkigome	391	11	-	-	HYPH
cord-264884-ydkigome	391	12	based	base	VBN
cord-264884-ydkigome	391	13	basal	basal	NN
cord-264884-ydkigome	391	14	life	life	NN
cord-264884-ydkigome	391	15	strategy	strategy	NN
cord-264884-ydkigome	391	16	provide	provide	VBP
cord-264884-ydkigome	391	17	some	some	DT
cord-264884-ydkigome	391	18	explanations	explanation	NNS
cord-264884-ydkigome	391	19	for	for	IN
cord-264884-ydkigome	391	20	the	the	DT
cord-264884-ydkigome	391	21	evolution	evolution	NN
cord-264884-ydkigome	391	22	of	of	IN
cord-264884-ydkigome	391	23	the	the	DT
cord-264884-ydkigome	391	24	higher	high	JJR
cord-264884-ydkigome	391	25	fi	fi	NNP
cord-264884-ydkigome	391	26	delity	delity	NNP
cord-264884-ydkigome	391	27	RNA	RNA	NNP
cord-264884-ydkigome	391	28	replicase	replicase	NN
cord-264884-ydkigome	391	29	of	of	IN
cord-264884-ydkigome	391	30	these	these	DT
cord-264884-ydkigome	391	31	coronaviruses	coronaviruse	NNS
cord-264884-ydkigome	391	32	?	?	.
cord-264884-ydkigome	392	1	As	as	IN
cord-264884-ydkigome	392	2	I	-PRON-	PRP
cord-264884-ydkigome	392	3	have	have	VBP
cord-264884-ydkigome	392	4	argued	argue	VBN
cord-264884-ydkigome	392	5	,	,	,
cord-264884-ydkigome	392	6	persistent	persistent	JJ
cord-264884-ydkigome	392	7	viral	viral	JJ
cord-264884-ydkigome	392	8	infection	infection	NN
cord-264884-ydkigome	392	9	represents	represent	VBZ
cord-264884-ydkigome	392	10	the	the	DT
cord-264884-ydkigome	392	11	majority	majority	NN
cord-264884-ydkigome	392	12	of	of	IN
cord-264884-ydkigome	392	13	evolutionary	evolutionary	JJ
cord-264884-ydkigome	392	14	stable	stable	JJ
cord-264884-ydkigome	392	15	viral	viral	JJ
cord-264884-ydkigome	392	16	lineages	lineage	NNS
cord-264884-ydkigome	392	17	(	(	-LRB-
cord-264884-ydkigome	392	18	Villarreal	Villarreal	NNP
cord-264884-ydkigome	392	19	,	,	,
cord-264884-ydkigome	392	20	2006	2006	CD
cord-264884-ydkigome	392	21	)	)	-RRB-
cord-264884-ydkigome	392	22	.	.	.
cord-264884-ydkigome	393	1	However	however	RB
cord-264884-ydkigome	393	2	,	,	,
cord-264884-ydkigome	393	3	we	-PRON-	PRP
cord-264884-ydkigome	393	4	have	have	VBP
cord-264884-ydkigome	393	5	almost	almost	RB
cord-264884-ydkigome	393	6	no	no	DT
cord-264884-ydkigome	393	7	knowledge	knowledge	NN
cord-264884-ydkigome	393	8	regarding	regard	VBG
cord-264884-ydkigome	393	9	how	how	WRB
cord-264884-ydkigome	393	10	these	these	DT
cord-264884-ydkigome	393	11	bat	bat	NN
cord-264884-ydkigome	393	12	SARS	SARS	NNP
cord-264884-ydkigome	393	13	viruses	virus	NNS
cord-264884-ydkigome	393	14	persist	persist	VBP
cord-264884-ydkigome	393	15	and	and	CC
cord-264884-ydkigome	393	16	escape	escape	VB
cord-264884-ydkigome	393	17	elimination	elimination	NN
cord-264884-ydkigome	393	18	by	by	IN
cord-264884-ydkigome	393	19	innate	innate	JJ
cord-264884-ydkigome	393	20	and	and	CC
cord-264884-ydkigome	393	21	adaptive	adaptive	JJ
cord-264884-ydkigome	393	22	immunity	immunity	NN
cord-264884-ydkigome	393	23	and	and	CC
cord-264884-ydkigome	393	24	what	what	WP
cord-264884-ydkigome	393	25	,	,	,
cord-264884-ydkigome	393	26	if	if	IN
cord-264884-ydkigome	393	27	any	any	DT
cord-264884-ydkigome	393	28	,	,	,
cord-264884-ydkigome	393	29	role	role	NN
cord-264884-ydkigome	393	30	the	the	DT
cord-264884-ydkigome	393	31	high	high	JJ
cord-264884-ydkigome	393	32	-	-	HYPH
cord-264884-ydkigome	393	33	fi	fi	NN
cord-264884-ydkigome	393	34	delity	delity	NN
cord-264884-ydkigome	393	35	replicase	replicase	NN
cord-264884-ydkigome	393	36	(	(	-LRB-
cord-264884-ydkigome	393	37	or	or	CC
cord-264884-ydkigome	393	38	other	other	JJ
cord-264884-ydkigome	393	39	genes	gene	NNS
cord-264884-ydkigome	393	40	)	)	-RRB-
cord-264884-ydkigome	393	41	have	have	VBP
cord-264884-ydkigome	393	42	in	in	IN
cord-264884-ydkigome	393	43	this	this	DT
cord-264884-ydkigome	393	44	life	life	NN
cord-264884-ydkigome	393	45	strategy	strategy	NN
cord-264884-ydkigome	393	46	.	.	.
cord-264884-ydkigome	394	1	Although	although	IN
cord-264884-ydkigome	394	2	we	-PRON-	PRP
cord-264884-ydkigome	394	3	can	can	MD
cord-264884-ydkigome	394	4	not	not	RB
cord-264884-ydkigome	394	5	yet	yet	RB
cord-264884-ydkigome	394	6	evaluate	evaluate	VB
cord-264884-ydkigome	394	7	natural	natural	JJ
cord-264884-ydkigome	394	8	SARS	SARS	NNP
cord-264884-ydkigome	394	9	virus	virus	NN
cord-264884-ydkigome	394	10	persistence	persistence	NN
cord-264884-ydkigome	394	11	in	in	IN
cord-264884-ydkigome	394	12	native	native	JJ
cord-264884-ydkigome	394	13	bat	bat	NN
cord-264884-ydkigome	394	14	hosts	host	NNS
cord-264884-ydkigome	394	15	,	,	,
cord-264884-ydkigome	394	16	another	another	DT
cord-264884-ydkigome	394	17	coronavirus	coronavirus	NN
cord-264884-ydkigome	394	18	may	may	MD
cord-264884-ydkigome	394	19	be	be	VB
cord-264884-ydkigome	394	20	more	more	RBR
cord-264884-ydkigome	394	21	informative	informative	JJ
cord-264884-ydkigome	394	22	regarding	regard	VBG
cord-264884-ydkigome	394	23	the	the	DT
cord-264884-ydkigome	394	24	effects	effect	NNS
cord-264884-ydkigome	394	25	of	of	IN
cord-264884-ydkigome	394	26	persistence	persistence	NN
cord-264884-ydkigome	394	27	on	on	IN
cord-264884-ydkigome	394	28	host	host	NN
cord-264884-ydkigome	394	29	populations	population	NNS
cord-264884-ydkigome	394	30	.	.	.
cord-264884-ydkigome	395	1	Mouse	Mouse	NNP
cord-264884-ydkigome	395	2	hepatitis	hepatitis	NN
cord-264884-ydkigome	395	3	virus	virus	NN
cord-264884-ydkigome	395	4	(	(	-LRB-
cord-264884-ydkigome	395	5	MHV	MHV	NNP
cord-264884-ydkigome	395	6	)	)	-RRB-
cord-264884-ydkigome	395	7	may	may	MD
cord-264884-ydkigome	395	8	provide	provide	VB
cord-264884-ydkigome	395	9	our	-PRON-	PRP$
cord-264884-ydkigome	395	10	best	good	JJS
cord-264884-ydkigome	395	11	exemplar	exemplar	NN
cord-264884-ydkigome	395	12	of	of	IN
cord-264884-ydkigome	395	13	virus	virus	NN
cord-264884-ydkigome	395	14	-	-	HYPH
cord-264884-ydkigome	395	15	host	host	NN
cord-264884-ydkigome	395	16	relationships	relationship	NNS
cord-264884-ydkigome	395	17	and	and	CC
cord-264884-ydkigome	395	18	show	show	VB
cord-264884-ydkigome	395	19	how	how	WRB
cord-264884-ydkigome	395	20	the	the	DT
cord-264884-ydkigome	395	21	concept	concept	NN
cord-264884-ydkigome	395	22	of	of	IN
cord-264884-ydkigome	395	23	virus	virus	NN
cord-264884-ydkigome	395	24	addiction	addiction	NN
cord-264884-ydkigome	395	25	relates	relate	VBZ
cord-264884-ydkigome	395	26	to	to	IN
cord-264884-ydkigome	395	27	population	population	NN
cord-264884-ydkigome	395	28	persistence	persistence	NN
cord-264884-ydkigome	395	29	.	.	.
cord-264884-ydkigome	396	1	MHV	MHV	NNP
cord-264884-ydkigome	396	2	is	be	VBZ
cord-264884-ydkigome	396	3	the	the	DT
cord-264884-ydkigome	396	4	best	well	RBS
cord-264884-ydkigome	396	5	-	-	HYPH
cord-264884-ydkigome	396	6	studied	study	VBN
cord-264884-ydkigome	396	7	coronavirus	coronavirus	NN
cord-264884-ydkigome	396	8	.	.	.
cord-264884-ydkigome	397	1	As	as	IN
cord-264884-ydkigome	397	2	a	a	DT
cord-264884-ydkigome	397	3	natural	natural	JJ
cord-264884-ydkigome	397	4	and	and	CC
cord-264884-ydkigome	397	5	prevalent	prevalent	JJ
cord-264884-ydkigome	397	6	virus	virus	NN
cord-264884-ydkigome	397	7	of	of	IN
cord-264884-ydkigome	397	8	rodents	rodent	NNS
cord-264884-ydkigome	397	9	,	,	,
cord-264884-ydkigome	397	10	MHV	MHV	NNP
cord-264884-ydkigome	397	11	is	be	VBZ
cord-264884-ydkigome	397	12	our	-PRON-	PRP$
cord-264884-ydkigome	397	13	best	good	JJS
cord-264884-ydkigome	397	14	natural	natural	JJ
cord-264884-ydkigome	397	15	model	model	NN
cord-264884-ydkigome	397	16	of	of	IN
cord-264884-ydkigome	397	17	persistent	persistent	JJ
cord-264884-ydkigome	397	18	RNA	RNA	NNP
cord-264884-ydkigome	397	19	virus	virus	NN
cord-264884-ydkigome	397	20	-	-	HYPH
cord-264884-ydkigome	397	21	host	host	NN
cord-264884-ydkigome	397	22	relationships	relationship	NNS
cord-264884-ydkigome	397	23	for	for	IN
cord-264884-ydkigome	397	24	any	any	DT
cord-264884-ydkigome	397	25	mammal	mammal	NN
cord-264884-ydkigome	397	26	.	.	.
cord-264884-ydkigome	398	1	In	in	IN
cord-264884-ydkigome	398	2	general	general	JJ
cord-264884-ydkigome	398	3	,	,	,
cord-264884-ydkigome	398	4	rodents	rodent	NNS
cord-264884-ydkigome	398	5	are	be	VBP
cord-264884-ydkigome	398	6	the	the	DT
cord-264884-ydkigome	398	7	most	most	RBS
cord-264884-ydkigome	398	8	studied	study	VBN
cord-264884-ydkigome	398	9	non	non	JJ
cord-264884-ydkigome	398	10	-	-	JJ
cord-264884-ydkigome	398	11	domestic	domestic	JJ
cord-264884-ydkigome	398	12	mammals	mammal	NNS
cord-264884-ydkigome	398	13	with	with	IN
cord-264884-ydkigome	398	14	regard	regard	NN
cord-264884-ydkigome	398	15	to	to	IN
cord-264884-ydkigome	398	16	natural	natural	JJ
cord-264884-ydkigome	398	17	virus	virus	NN
cord-264884-ydkigome	398	18	distribution	distribution	NN
cord-264884-ydkigome	398	19	.	.	.
cord-264884-ydkigome	399	1	Overall	overall	RB
cord-264884-ydkigome	399	2	,	,	,
cord-264884-ydkigome	399	3	we	-PRON-	PRP
cord-264884-ydkigome	399	4	know	know	VBP
cord-264884-ydkigome	399	5	that	that	IN
cord-264884-ydkigome	399	6	wild	wild	NN
cord-264884-ydkigome	399	7	-	-	HYPH
cord-264884-ydkigome	399	8	caught	catch	VBN
cord-264884-ydkigome	399	9	rodents	rodent	NNS
cord-264884-ydkigome	399	10	seldom	seldom	RB
cord-264884-ydkigome	399	11	show	show	VBP
cord-264884-ydkigome	399	12	signs	sign	NNS
cord-264884-ydkigome	399	13	of	of	IN
cord-264884-ydkigome	399	14	acute	acute	JJ
cord-264884-ydkigome	399	15	virus	virus	NN
cord-264884-ydkigome	399	16	infection	infection	NN
cord-264884-ydkigome	399	17	(	(	-LRB-
cord-264884-ydkigome	399	18	Kashuba	Kashuba	NNP
cord-264884-ydkigome	399	19	et	et	FW
cord-264884-ydkigome	399	20	al	al	NNP
cord-264884-ydkigome	399	21	.	.	NNP
cord-264884-ydkigome	399	22	,	,	,
cord-264884-ydkigome	399	23	2005	2005	CD
cord-264884-ydkigome	399	24	)	)	-RRB-
cord-264884-ydkigome	399	25	.	.	.
cord-264884-ydkigome	400	1	However	however	RB
cord-264884-ydkigome	400	2	,	,	,
cord-264884-ydkigome	400	3	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	400	4	virus	virus	NN
cord-264884-ydkigome	400	5	persistence	persistence	NN
cord-264884-ydkigome	400	6	is	be	VBZ
cord-264884-ydkigome	400	7	ubiquitous	ubiquitous	JJ
cord-264884-ydkigome	400	8	in	in	IN
cord-264884-ydkigome	400	9	wild	wild	JJ
cord-264884-ydkigome	400	10	rodents	rodent	NNS
cord-264884-ydkigome	400	11	(	(	-LRB-
cord-264884-ydkigome	400	12	Descoteaux	Descoteaux	NNP
cord-264884-ydkigome	400	13	et	et	NNP
cord-264884-ydkigome	400	14	al	al	NNP
cord-264884-ydkigome	400	15	.	.	NNP
cord-264884-ydkigome	400	16	,	,	,
cord-264884-ydkigome	400	17	1977	1977	CD
cord-264884-ydkigome	400	18	;	;	:
cord-264884-ydkigome	400	19	Gannon	Gannon	NNP
cord-264884-ydkigome	400	20	and	and	CC
cord-264884-ydkigome	400	21	Carthew	Carthew	NNP
cord-264884-ydkigome	400	22	,	,	,
cord-264884-ydkigome	400	23	1980	1980	CD
cord-264884-ydkigome	400	24	;	;	:
cord-264884-ydkigome	400	25	Schoondermark	Schoondermark	NNP
cord-264884-ydkigome	400	26	-	-	HYPH
cord-264884-ydkigome	400	27	van	van	NNP
cord-264884-ydkigome	400	28	de	de	FW
cord-264884-ydkigome	400	29	Ven	Ven	NNP
cord-264884-ydkigome	400	30	et	et	NNP
cord-264884-ydkigome	400	31	al	al	NNP
cord-264884-ydkigome	400	32	.	.	NNP
cord-264884-ydkigome	400	33	,	,	,
cord-264884-ydkigome	400	34	2006	2006	CD
cord-264884-ydkigome	400	35	)	)	-RRB-
cord-264884-ydkigome	400	36	,	,	,
cord-264884-ydkigome	400	37	including	include	VBG
cord-264884-ydkigome	400	38	voles	vole	NNS
cord-264884-ydkigome	400	39	(	(	-LRB-
cord-264884-ydkigome	400	40	Descoteaux	Descoteaux	NNP
cord-264884-ydkigome	400	41	and	and	CC
cord-264884-ydkigome	400	42	Mihok	Mihok	NNP
cord-264884-ydkigome	400	43	,	,	,
cord-264884-ydkigome	400	44	1986	1986	CD
cord-264884-ydkigome	400	45	)	)	-RRB-
cord-264884-ydkigome	400	46	.	.	.
cord-264884-ydkigome	401	1	Some	some	DT
cord-264884-ydkigome	401	2	fi	fi	NN
cord-264884-ydkigome	401	3	eld	eld	NNP
cord-264884-ydkigome	401	4	studies	study	NNS
cord-264884-ydkigome	401	5	have	have	VBP
cord-264884-ydkigome	401	6	evaluated	evaluate	VBN
cord-264884-ydkigome	401	7	broader	broad	JJR
cord-264884-ydkigome	401	8	patterns	pattern	NNS
cord-264884-ydkigome	401	9	of	of	IN
cord-264884-ydkigome	401	10	virus	virus	NN
cord-264884-ydkigome	401	11	persistence	persistence	NN
cord-264884-ydkigome	401	12	in	in	IN
cord-264884-ydkigome	401	13	mice	mouse	NNS
cord-264884-ydkigome	401	14	(	(	-LRB-
cord-264884-ydkigome	401	15	Singleton	Singleton	NNP
cord-264884-ydkigome	401	16	et	et	FW
cord-264884-ydkigome	401	17	al	al	NNP
cord-264884-ydkigome	401	18	.	.	NNP
cord-264884-ydkigome	401	19	,	,	,
cord-264884-ydkigome	401	20	1993	1993	CD
cord-264884-ydkigome	401	21	;	;	:
cord-264884-ydkigome	401	22	Becker	Becker	NNP
cord-264884-ydkigome	401	23	et	et	NNP
cord-264884-ydkigome	401	24	al	al	NNP
cord-264884-ydkigome	401	25	.	.	NNP
cord-264884-ydkigome	401	26	,	,	,
cord-264884-ydkigome	401	27	2007	2007	CD
cord-264884-ydkigome	401	28	)	)	-RRB-
cord-264884-ydkigome	401	29	which	which	WDT
cord-264884-ydkigome	401	30	indicated	indicate	VBD
cord-264884-ydkigome	401	31	that	that	IN
cord-264884-ydkigome	401	32	wild	wild	JJ
cord-264884-ydkigome	401	33	house	house	NN
cord-264884-ydkigome	401	34	mice	mouse	NNS
cord-264884-ydkigome	401	35	are	be	VBP
cord-264884-ydkigome	401	36	highly	highly	RB
cord-264884-ydkigome	401	37	colonized	colonize	VBN
cord-264884-ydkigome	401	38	with	with	IN
cord-264884-ydkigome	401	39	MHV	MHV	NNP
cord-264884-ydkigome	401	40	(	(	-LRB-
cord-264884-ydkigome	401	41	80	80	CD
cord-264884-ydkigome	401	42	-	-	SYM
cord-264884-ydkigome	401	43	100	100	CD
cord-264884-ydkigome	401	44	%	%	NN
cord-264884-ydkigome	401	45	prevalence	prevalence	NN
cord-264884-ydkigome	401	46	)	)	-RRB-
cord-264884-ydkigome	401	47	.	.	.
cord-264884-ydkigome	402	1	In	in	IN
cord-264884-ydkigome	402	2	addition	addition	NN
cord-264884-ydkigome	402	3	to	to	IN
cord-264884-ydkigome	402	4	MHV	MHV	NNP
cord-264884-ydkigome	402	5	,	,	,
cord-264884-ydkigome	402	6	mouse	mouse	NN
cord-264884-ydkigome	402	7	cytomegalovirus	cytomegalovirus	NN
cord-264884-ydkigome	402	8	,	,	,
cord-264884-ydkigome	402	9	mouse	mouse	NN
cord-264884-ydkigome	402	10	parvovirus	parvovirus	NN
cord-264884-ydkigome	402	11	,	,	,
cord-264884-ydkigome	402	12	mouse	mouse	NN
cord-264884-ydkigome	402	13	thymic	thymic	JJ
cord-264884-ydkigome	402	14	virus	virus	NN
cord-264884-ydkigome	402	15	,	,	,
cord-264884-ydkigome	402	16	and	and	CC
cord-264884-ydkigome	402	17	mouse	mouse	NN
cord-264884-ydkigome	402	18	adenovirus	adenovirus	NN
cord-264884-ydkigome	402	19	are	be	VBP
cord-264884-ydkigome	402	20	also	also	RB
cord-264884-ydkigome	402	21	prevalent	prevalent	JJ
cord-264884-ydkigome	402	22	.	.	.
cord-264884-ydkigome	403	1	Other	other	JJ
cord-264884-ydkigome	403	2	well	well	RB
cord-264884-ydkigome	403	3	-	-	HYPH
cord-264884-ydkigome	403	4	studied	study	VBN
cord-264884-ydkigome	403	5	mouse	mouse	NN
cord-264884-ydkigome	403	6	viruses	virus	NNS
cord-264884-ydkigome	403	7	,	,	,
cord-264884-ydkigome	403	8	such	such	JJ
cord-264884-ydkigome	403	9	as	as	IN
cord-264884-ydkigome	403	10	lymphocytic	lymphocytic	JJ
cord-264884-ydkigome	403	11	choriomeningitis	choriomeningitis	NNP
cord-264884-ydkigome	403	12	virus	virus	NN
cord-264884-ydkigome	403	13	(	(	-LRB-
cord-264884-ydkigome	403	14	LCMV	LCMV	NNP
cord-264884-ydkigome	403	15	)	)	-RRB-
cord-264884-ydkigome	403	16	and	and	CC
cord-264884-ydkigome	403	17	polyomavirus	polyomavirus	NNP
cord-264884-ydkigome	403	18	(	(	-LRB-
cord-264884-ydkigome	403	19	PyV	PyV	NNP
cord-264884-ydkigome	403	20	)	)	-RRB-
cord-264884-ydkigome	403	21	,	,	,
cord-264884-ydkigome	403	22	were	be	VBD
cord-264884-ydkigome	403	23	at	at	IN
cord-264884-ydkigome	403	24	low	low	JJ
cord-264884-ydkigome	403	25	natural	natural	JJ
cord-264884-ydkigome	403	26	prevalence	prevalence	NN
cord-264884-ydkigome	403	27	.	.	.
cord-264884-ydkigome	404	1	Interestingly	interestingly	RB
cord-264884-ydkigome	404	2	,	,	,
cord-264884-ydkigome	404	3	some	some	DT
cord-264884-ydkigome	404	4	non	non	JJ
cord-264884-ydkigome	404	5	-	-	JJ
cord-264884-ydkigome	404	6	native	native	JJ
cord-264884-ydkigome	404	7	house	house	NN
cord-264884-ydkigome	404	8	mice	mouse	NNS
cord-264884-ydkigome	404	9	that	that	WDT
cord-264884-ydkigome	404	10	have	have	VBP
cord-264884-ydkigome	404	11	colonized	colonize	VBN
cord-264884-ydkigome	404	12	isolated	isolate	VBN
cord-264884-ydkigome	404	13	islands	island	NNS
cord-264884-ydkigome	404	14	may	may	MD
cord-264884-ydkigome	404	15	lack	lack	VB
cord-264884-ydkigome	404	16	MHV	MHV	NNP
cord-264884-ydkigome	404	17	(	(	-LRB-
cord-264884-ydkigome	404	18	Moro	Moro	NNP
cord-264884-ydkigome	404	19	et	et	FW
cord-264884-ydkigome	404	20	al	al	NNP
cord-264884-ydkigome	404	21	.	.	NNP
cord-264884-ydkigome	404	22	,	,	,
cord-264884-ydkigome	404	23	1999	1999	CD
cord-264884-ydkigome	404	24	)	)	-RRB-
cord-264884-ydkigome	404	25	,	,	,
cord-264884-ydkigome	404	26	although	although	IN
cord-264884-ydkigome	404	27	most	most	JJS
cord-264884-ydkigome	404	28	other	other	JJ
cord-264884-ydkigome	404	29	isolated	isolate	VBN
cord-264884-ydkigome	404	30	island	island	NN
cord-264884-ydkigome	404	31	populations	population	NNS
cord-264884-ydkigome	404	32	retain	retain	VBP
cord-264884-ydkigome	404	33	MHV	MHV	NNP
cord-264884-ydkigome	404	34	(	(	-LRB-
cord-264884-ydkigome	404	35	Moro	Moro	NNP
cord-264884-ydkigome	404	36	et	et	FW
cord-264884-ydkigome	404	37	al	al	NNP
cord-264884-ydkigome	404	38	.	.	NNP
cord-264884-ydkigome	404	39	,	,	,
cord-264884-ydkigome	404	40	2003	2003	CD
cord-264884-ydkigome	404	41	)	)	-RRB-
cord-264884-ydkigome	404	42	.	.	.
cord-264884-ydkigome	405	1	Other	other	JJ
cord-264884-ydkigome	405	2	small	small	JJ
cord-264884-ydkigome	405	3	mammals	mammal	NNS
cord-264884-ydkigome	405	4	have	have	VBP
cord-264884-ydkigome	405	5	yet	yet	RB
cord-264884-ydkigome	405	6	to	to	TO
cord-264884-ydkigome	405	7	show	show	VB
cord-264884-ydkigome	405	8	any	any	DT
cord-264884-ydkigome	405	9	viral	viral	JJ
cord-264884-ydkigome	405	10	disease	disease	NN
cord-264884-ydkigome	405	11	whatsoever	whatsoever	RB
cord-264884-ydkigome	405	12	(	(	-LRB-
cord-264884-ydkigome	405	13	hedgehogs	hedgehog	NNS
cord-264884-ydkigome	405	14	,	,	,
cord-264884-ydkigome	405	15	chinchillas	chinchilla	NNS
cord-264884-ydkigome	405	16	,	,	,
cord-264884-ydkigome	405	17	prairie	prairie	NN
cord-264884-ydkigome	405	18	dogs	dog	NNS
cord-264884-ydkigome	405	19	,	,	,
cord-264884-ydkigome	405	20	gerbils	gerbil	NNS
cord-264884-ydkigome	405	21	,	,	,
cord-264884-ydkigome	405	22	sugar	sugar	NN
cord-264884-ydkigome	405	23	gliders	glider	NNS
cord-264884-ydkigome	405	24	)	)	-RRB-
cord-264884-ydkigome	406	1	(	(	-LRB-
cord-264884-ydkigome	406	2	Kashuba	Kashuba	NNP
cord-264884-ydkigome	406	3	et	et	NNP
cord-264884-ydkigome	406	4	al	al	NNP
cord-264884-ydkigome	406	5	.	.	NNP
cord-264884-ydkigome	406	6	,	,	,
cord-264884-ydkigome	406	7	2005	2005	CD
cord-264884-ydkigome	406	8	)	)	-RRB-
cord-264884-ydkigome	406	9	.	.	.
cord-264884-ydkigome	407	1	Thus	thus	RB
cord-264884-ydkigome	407	2	,	,	,
cord-264884-ydkigome	407	3	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	407	4	persistent	persistent	JJ
cord-264884-ydkigome	407	5	viral	viral	JJ
cord-264884-ydkigome	407	6	infection	infection	NN
cord-264884-ydkigome	407	7	is	be	VBZ
cord-264884-ydkigome	407	8	clearly	clearly	RB
cord-264884-ydkigome	407	9	the	the	DT
cord-264884-ydkigome	407	10	norm	norm	NN
cord-264884-ydkigome	407	11	in	in	IN
cord-264884-ydkigome	407	12	rodents	rodent	NNS
cord-264884-ydkigome	407	13	.	.	.
cord-264884-ydkigome	408	1	Yet	yet	RB
cord-264884-ydkigome	408	2	,	,	,
cord-264884-ydkigome	408	3	in	in	IN
cord-264884-ydkigome	408	4	spite	spite	NN
cord-264884-ydkigome	408	5	of	of	IN
cord-264884-ydkigome	408	6	this	this	DT
cord-264884-ydkigome	408	7	usual	usual	JJ
cord-264884-ydkigome	408	8	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	408	9	viral	viral	JJ
cord-264884-ydkigome	408	10	persistence	persistence	NN
cord-264884-ydkigome	408	11	,	,	,
cord-264884-ydkigome	408	12	historically	historically	RB
cord-264884-ydkigome	408	13	,	,	,
cord-264884-ydkigome	408	14	some	some	DT
cord-264884-ydkigome	408	15	zoonotic	zoonotic	JJ
cord-264884-ydkigome	408	16	viral	viral	JJ
cord-264884-ydkigome	408	17	disease	disease	NN
cord-264884-ydkigome	408	18	outbreaks	outbreak	NNS
cord-264884-ydkigome	408	19	have	have	VBP
cord-264884-ydkigome	408	20	occasionally	occasionally	RB
cord-264884-ydkigome	408	21	been	be	VBN
cord-264884-ydkigome	408	22	documented	document	VBN
cord-264884-ydkigome	408	23	in	in	IN
cord-264884-ydkigome	408	24	natural	natural	JJ
cord-264884-ydkigome	408	25	populations	population	NNS
cord-264884-ydkigome	408	26	.	.	.
cord-264884-ydkigome	409	1	One	one	CD
cord-264884-ydkigome	409	2	such	such	JJ
cord-264884-ydkigome	409	3	early	early	JJ
cord-264884-ydkigome	409	4	outbreak	outbreak	NN
cord-264884-ydkigome	409	5	was	be	VBD
cord-264884-ydkigome	409	6	an	an	DT
cord-264884-ydkigome	409	7	epizootic	epizootic	JJ
cord-264884-ydkigome	409	8	diarrhea	diarrhea	NN
cord-264884-ydkigome	409	9	that	that	WDT
cord-264884-ydkigome	409	10	occurred	occur	VBD
cord-264884-ydkigome	409	11	in	in	IN
cord-264884-ydkigome	409	12	infant	infant	NN
cord-264884-ydkigome	409	13	mice	mouse	NNS
cord-264884-ydkigome	409	14	(	(	-LRB-
cord-264884-ydkigome	409	15	Adams	Adams	NNP
cord-264884-ydkigome	409	16	and	and	CC
cord-264884-ydkigome	409	17	Kraft	Kraft	NNP
cord-264884-ydkigome	409	18	,	,	,
cord-264884-ydkigome	409	19	1963	1963	CD
cord-264884-ydkigome	409	20	)	)	-RRB-
cord-264884-ydkigome	409	21	.	.	.
cord-264884-ydkigome	410	1	Later	later	RB
cord-264884-ydkigome	410	2	,	,	,
cord-264884-ydkigome	410	3	it	-PRON-	PRP
cord-264884-ydkigome	410	4	was	be	VBD
cord-264884-ydkigome	410	5	established	establish	VBN
cord-264884-ydkigome	410	6	that	that	IN
cord-264884-ydkigome	410	7	one	one	CD
cord-264884-ydkigome	410	8	such	such	JJ
cord-264884-ydkigome	410	9	infection	infection	NN
cord-264884-ydkigome	410	10	was	be	VBD
cord-264884-ydkigome	410	11	due	due	JJ
cord-264884-ydkigome	410	12	to	to	IN
cord-264884-ydkigome	410	13	mouse	mouse	NNP
cord-264884-ydkigome	410	14	hepatitis	hepatitis	NNP
cord-264884-ydkigome	410	15	virus	virus	NN
cord-264884-ydkigome	410	16	(	(	-LRB-
cord-264884-ydkigome	410	17	Carthew	Carthew	NNP
cord-264884-ydkigome	410	18	,	,	,
cord-264884-ydkigome	410	19	1977	1977	CD
cord-264884-ydkigome	410	20	;	;	.
cord-264884-ydkigome	411	1	Ishida	Ishida	NNP
cord-264884-ydkigome	411	2	et	et	NNP
cord-264884-ydkigome	411	3	al	al	NNP
cord-264884-ydkigome	411	4	.	.	NNP
cord-264884-ydkigome	411	5	,	,	,
cord-264884-ydkigome	411	6	1978	1978	CD
cord-264884-ydkigome	411	7	)	)	-RRB-
cord-264884-ydkigome	411	8	.	.	.
cord-264884-ydkigome	412	1	In	in	IN
cord-264884-ydkigome	412	2	spite	spite	NN
cord-264884-ydkigome	412	3	of	of	IN
cord-264884-ydkigome	412	4	this	this	DT
cord-264884-ydkigome	412	5	disease	disease	NN
cord-264884-ydkigome	412	6	outbreak	outbreak	NN
cord-264884-ydkigome	412	7	,	,	,
cord-264884-ydkigome	412	8	with	with	IN
cord-264884-ydkigome	412	9	MHV	MHV	NNP
cord-264884-ydkigome	412	10	,	,	,
cord-264884-ydkigome	412	11	it	-PRON-	PRP
cord-264884-ydkigome	412	12	has	have	VBZ
cord-264884-ydkigome	412	13	since	since	RB
cord-264884-ydkigome	412	14	become	become	VBN
cord-264884-ydkigome	412	15	clear	clear	JJ
cord-264884-ydkigome	412	16	that	that	IN
cord-264884-ydkigome	412	17	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	412	18	persistent	persistent	JJ
cord-264884-ydkigome	412	19	infections	infection	NNS
cord-264884-ydkigome	412	20	are	be	VBP
cord-264884-ydkigome	412	21	the	the	DT
cord-264884-ydkigome	412	22	norm	norm	NN
cord-264884-ydkigome	412	23	and	and	CC
cord-264884-ydkigome	412	24	are	be	VBP
cord-264884-ydkigome	412	25	highly	highly	RB
cord-264884-ydkigome	412	26	stable	stable	JJ
cord-264884-ydkigome	412	27	.	.	.
cord-264884-ydkigome	413	1	Yet	yet	CC
cord-264884-ydkigome	413	2	MHV	MHV	NNP
cord-264884-ydkigome	413	3	disease	disease	NN
cord-264884-ydkigome	413	4	outbreaks	outbreak	NNS
cord-264884-ydkigome	413	5	,	,	,
cord-264884-ydkigome	413	6	especially	especially	RB
cord-264884-ydkigome	413	7	in	in	IN
cord-264884-ydkigome	413	8	virus	virus	NN
cord-264884-ydkigome	413	9	-	-	HYPH
cord-264884-ydkigome	413	10	free	free	JJ
cord-264884-ydkigome	413	11	mouse	mouse	NN
cord-264884-ydkigome	413	12	facilities	facility	NNS
cord-264884-ydkigome	413	13	,	,	,
cord-264884-ydkigome	413	14	are	be	VBP
cord-264884-ydkigome	413	15	also	also	RB
cord-264884-ydkigome	413	16	common	common	JJ
cord-264884-ydkigome	413	17	and	and	CC
cord-264884-ydkigome	413	18	severe	severe	JJ
cord-264884-ydkigome	413	19	.	.	.
cord-264884-ydkigome	414	1	How	how	WRB
cord-264884-ydkigome	414	2	does	do	VBZ
cord-264884-ydkigome	414	3	MHV	MHV	NNP
cord-264884-ydkigome	414	4	attain	attain	VB
cord-264884-ydkigome	414	5	such	such	JJ
cord-264884-ydkigome	414	6	stable	stable	JJ
cord-264884-ydkigome	414	7	and	and	CC
cord-264884-ydkigome	414	8	prevalent	prevalent	JJ
cord-264884-ydkigome	414	9	persistence	persistence	NN
cord-264884-ydkigome	414	10	in	in	IN
cord-264884-ydkigome	414	11	natural	natural	JJ
cord-264884-ydkigome	414	12	population	population	NN
cord-264884-ydkigome	414	13	yet	yet	RB
cord-264884-ydkigome	414	14	retain	retain	VBP
cord-264884-ydkigome	414	15	the	the	DT
cord-264884-ydkigome	414	16	ability	ability	NN
cord-264884-ydkigome	414	17	to	to	TO
cord-264884-ydkigome	414	18	cause	cause	VB
cord-264884-ydkigome	414	19	disease	disease	NN
cord-264884-ydkigome	414	20	in	in	IN
cord-264884-ydkigome	414	21	naive	naive	JJ
cord-264884-ydkigome	414	22	populations	population	NNS
cord-264884-ydkigome	414	23	?	?	.
cord-264884-ydkigome	415	1	What	what	WP
cord-264884-ydkigome	415	2	maintains	maintain	VBZ
cord-264884-ydkigome	415	3	the	the	DT
cord-264884-ydkigome	415	4	MHV	MHV	NNP
cord-264884-ydkigome	415	5	fi	fi	NN
cord-264884-ydkigome	415	6	tness	tness	NN
cord-264884-ydkigome	415	7	of	of	IN
cord-264884-ydkigome	415	8	natural	natural	JJ
cord-264884-ydkigome	415	9	persistence	persistence	NN
cord-264884-ydkigome	415	10	?	?	.
cord-264884-ydkigome	416	1	It	-PRON-	PRP
cord-264884-ydkigome	416	2	is	be	VBZ
cord-264884-ydkigome	416	3	well	well	RB
cord-264884-ydkigome	416	4	known	know	VBN
cord-264884-ydkigome	416	5	that	that	IN
cord-264884-ydkigome	416	6	once	once	IN
cord-264884-ydkigome	416	7	MHV	MHV	NNP
cord-264884-ydkigome	416	8	is	be	VBZ
cord-264884-ydkigome	416	9	established	establish	VBN
cord-264884-ydkigome	416	10	in	in	IN
cord-264884-ydkigome	416	11	a	a	DT
cord-264884-ydkigome	416	12	mouse	mouse	NN
cord-264884-ydkigome	416	13	or	or	CC
cord-264884-ydkigome	416	14	rat	rat	NN
cord-264884-ydkigome	416	15	colony	colony	NN
cord-264884-ydkigome	416	16	it	-PRON-	PRP
cord-264884-ydkigome	416	17	can	can	MD
cord-264884-ydkigome	416	18	be	be	VB
cord-264884-ydkigome	416	19	very	very	RB
cord-264884-ydkigome	416	20	diffi	diffi	JJ
cord-264884-ydkigome	416	21	cult	cult	NN
cord-264884-ydkigome	416	22	to	to	TO
cord-264884-ydkigome	416	23	eliminate	eliminate	VB
cord-264884-ydkigome	416	24	(	(	-LRB-
cord-264884-ydkigome	416	25	Gannon	Gannon	NNP
cord-264884-ydkigome	416	26	and	and	CC
cord-264884-ydkigome	416	27	Carthew	Carthew	NNP
cord-264884-ydkigome	416	28	,	,	,
cord-264884-ydkigome	416	29	1980	1980	CD
cord-264884-ydkigome	416	30	;	;	:
cord-264884-ydkigome	416	31	Lussier	Lussier	NNP
cord-264884-ydkigome	416	32	and	and	CC
cord-264884-ydkigome	416	33	Descoteaux	Descoteaux	NNP
cord-264884-ydkigome	416	34	,	,	,
cord-264884-ydkigome	416	35	1986	1986	CD
cord-264884-ydkigome	416	36	)	)	-RRB-
cord-264884-ydkigome	416	37	,	,	,
cord-264884-ydkigome	416	38	clearly	clearly	RB
cord-264884-ydkigome	416	39	indicating	indicate	VBG
cord-264884-ydkigome	416	40	that	that	IN
cord-264884-ydkigome	416	41	stability	stability	NN
cord-264884-ydkigome	416	42	is	be	VBZ
cord-264884-ydkigome	416	43	rapidly	rapidly	RB
cord-264884-ydkigome	416	44	attained	attain	VBN
cord-264884-ydkigome	416	45	and	and	CC
cord-264884-ydkigome	416	46	likely	likely	JJ
cord-264884-ydkigome	416	47	genetically	genetically	RB
cord-264884-ydkigome	416	48	programmed	program	VBN
cord-264884-ydkigome	416	49	by	by	IN
cord-264884-ydkigome	416	50	the	the	DT
cord-264884-ydkigome	416	51	virus	virus	NN
cord-264884-ydkigome	416	52	.	.	.
cord-264884-ydkigome	417	1	I	-PRON-	PRP
cord-264884-ydkigome	417	2	propose	propose	VBP
cord-264884-ydkigome	417	3	that	that	IN
cord-264884-ydkigome	417	4	these	these	DT
cord-264884-ydkigome	417	5	stable	stable	JJ
cord-264884-ydkigome	417	6	evolutionary	evolutionary	JJ
cord-264884-ydkigome	417	7	states	state	NNS
cord-264884-ydkigome	417	8	of	of	IN
cord-264884-ydkigome	417	9	viral	viral	JJ
cord-264884-ydkigome	417	10	persistence	persistence	NN
cord-264884-ydkigome	417	11	are	be	VBP
cord-264884-ydkigome	417	12	due	due	JJ
cord-264884-ydkigome	417	13	to	to	IN
cord-264884-ydkigome	417	14	a	a	DT
cord-264884-ydkigome	417	15	strategy	strategy	NN
cord-264884-ydkigome	417	16	we	-PRON-	PRP
cord-264884-ydkigome	417	17	can	can	MD
cord-264884-ydkigome	417	18	call	call	VB
cord-264884-ydkigome	417	19	virus	virus	NN
cord-264884-ydkigome	417	20	addiction	addiction	NN
cord-264884-ydkigome	417	21	(	(	-LRB-
cord-264884-ydkigome	417	22	Villarreal	Villarreal	NNP
cord-264884-ydkigome	417	23	,	,	,
cord-264884-ydkigome	417	24	2005	2005	CD
cord-264884-ydkigome	417	25	)	)	-RRB-
cord-264884-ydkigome	417	26	and	and	CC
cord-264884-ydkigome	417	27	that	that	IN
cord-264884-ydkigome	417	28	MHV	MHV	NNP
cord-264884-ydkigome	417	29	can	can	MD
cord-264884-ydkigome	417	30	provide	provide	VB
cord-264884-ydkigome	417	31	the	the	DT
cord-264884-ydkigome	417	32	exemplar	exemplar	NN
cord-264884-ydkigome	417	33	of	of	IN
cord-264884-ydkigome	417	34	such	such	PDT
cord-264884-ydkigome	417	35	a	a	DT
cord-264884-ydkigome	417	36	state	state	NN
cord-264884-ydkigome	417	37	.	.	.
cord-264884-ydkigome	418	1	With	with	IN
cord-264884-ydkigome	418	2	MHV	MHV	NNP
cord-264884-ydkigome	418	3	,	,	,
cord-264884-ydkigome	418	4	only	only	RB
cord-264884-ydkigome	418	5	persistently	persistently	RB
cord-264884-ydkigome	418	6	infected	infected	JJ
cord-264884-ydkigome	418	7	mice	mice	NN
cord-264884-ydkigome	418	8	colonies	colony	NNS
cord-264884-ydkigome	418	9	are	be	VBP
cord-264884-ydkigome	418	10	protected	protect	VBN
cord-264884-ydkigome	418	11	from	from	IN
cord-264884-ydkigome	418	12	the	the	DT
cord-264884-ydkigome	418	13	disease	disease	NN
cord-264884-ydkigome	418	14	that	that	WDT
cord-264884-ydkigome	418	15	is	be	VBZ
cord-264884-ydkigome	418	16	otherwise	otherwise	RB
cord-264884-ydkigome	418	17	caused	cause	VBN
cord-264884-ydkigome	418	18	by	by	IN
cord-264884-ydkigome	418	19	the	the	DT
cord-264884-ydkigome	418	20	virus	virus	NN
cord-264884-ydkigome	418	21	.	.	.
cord-264884-ydkigome	419	1	In	in	IN
cord-264884-ydkigome	419	2	wild	wild	JJ
cord-264884-ydkigome	419	3	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	419	4	mice	mouse	NNS
cord-264884-ydkigome	419	5	,	,	,
cord-264884-ydkigome	419	6	MHV	MHV	NNP
cord-264884-ydkigome	419	7	is	be	VBZ
cord-264884-ydkigome	419	8	found	find	VBN
cord-264884-ydkigome	419	9	mostly	mostly	RB
cord-264884-ydkigome	419	10	as	as	IN
cord-264884-ydkigome	419	11	an	an	DT
cord-264884-ydkigome	419	12	enteric	enteric	JJ
cord-264884-ydkigome	419	13	infection	infection	NN
cord-264884-ydkigome	419	14	.	.	.
cord-264884-ydkigome	420	1	The	the	DT
cord-264884-ydkigome	420	2	CNS	CNS	NNP
cord-264884-ydkigome	420	3	demyelinated	demyelinate	VBN
cord-264884-ydkigome	420	4	disease	disease	NN
cord-264884-ydkigome	420	5	that	that	WDT
cord-264884-ydkigome	420	6	MHV	MHV	NNP
cord-264884-ydkigome	420	7	can	can	MD
cord-264884-ydkigome	420	8	induce	induce	VB
cord-264884-ydkigome	420	9	is	be	VBZ
cord-264884-ydkigome	420	10	most	most	RBS
cord-264884-ydkigome	420	11	observed	observe	VBN
cord-264884-ydkigome	420	12	in	in	IN
cord-264884-ydkigome	420	13	newborn	newborn	JJ
cord-264884-ydkigome	420	14	pups	pup	NNS
cord-264884-ydkigome	420	15	(	(	-LRB-
cord-264884-ydkigome	420	16	Homberger	Homberger	NNP
cord-264884-ydkigome	420	17	,	,	,
cord-264884-ydkigome	420	18	1997	1997	CD
cord-264884-ydkigome	420	19	;	;	:
cord-264884-ydkigome	420	20	Nash	Nash	NNP
cord-264884-ydkigome	420	21	et	et	NNP
cord-264884-ydkigome	420	22	al	al	NNP
cord-264884-ydkigome	420	23	.	.	NNP
cord-264884-ydkigome	420	24	,	,	,
cord-264884-ydkigome	420	25	2001	2001	CD
cord-264884-ydkigome	420	26	)	)	-RRB-
cord-264884-ydkigome	420	27	and	and	CC
cord-264884-ydkigome	420	28	once	once	RB
cord-264884-ydkigome	420	29	in	in	IN
cord-264884-ydkigome	420	30	the	the	DT
cord-264884-ydkigome	420	31	brain	brain	NN
cord-264884-ydkigome	420	32	,	,	,
cord-264884-ydkigome	420	33	MHV	MHV	NNP
cord-264884-ydkigome	420	34	can	can	MD
cord-264884-ydkigome	420	35	persist	persist	VB
cord-264884-ydkigome	420	36	in	in	IN
cord-264884-ydkigome	420	37	CNS	CNS	NNP
cord-264884-ydkigome	420	38	with	with	IN
cord-264884-ydkigome	420	39	recurring	recur	VBG
cord-264884-ydkigome	420	40	disease	disease	NN
cord-264884-ydkigome	420	41	(	(	-LRB-
cord-264884-ydkigome	420	42	Marten	Marten	NNP
cord-264884-ydkigome	420	43	et	et	NNP
cord-264884-ydkigome	420	44	al	al	NNP
cord-264884-ydkigome	420	45	.	.	NNP
cord-264884-ydkigome	420	46	,	,	,
cord-264884-ydkigome	420	47	2001	2001	CD
cord-264884-ydkigome	420	48	)	)	-RRB-
cord-264884-ydkigome	420	49	.	.	.
cord-264884-ydkigome	421	1	This	this	DT
cord-264884-ydkigome	421	2	recurring	recur	VBG
cord-264884-ydkigome	421	3	CNS	CNS	NNP
cord-264884-ydkigome	421	4	disease	disease	NN
cord-264884-ydkigome	421	5	is	be	VBZ
cord-264884-ydkigome	421	6	also	also	RB
cord-264884-ydkigome	421	7	associated	associate	VBN
cord-264884-ydkigome	421	8	with	with	IN
cord-264884-ydkigome	421	9	quasispecies	quasispecie	NNS
cord-264884-ydkigome	421	10	(	(	-LRB-
cord-264884-ydkigome	421	11	in	in	IN
cord-264884-ydkigome	421	12	the	the	DT
cord-264884-ydkigome	421	13	S	S	NNP
cord-264884-ydkigome	421	14	gene	gene	NN
cord-264884-ydkigome	421	15	)	)	-RRB-
cord-264884-ydkigome	421	16	and	and	CC
cord-264884-ydkigome	421	17	recombination	recombination	NN
cord-264884-ydkigome	421	18	(	(	-LRB-
cord-264884-ydkigome	421	19	Rowe	Rowe	NNP
cord-264884-ydkigome	421	20	et	et	NNP
cord-264884-ydkigome	421	21	al	al	NNP
cord-264884-ydkigome	421	22	.	.	NNP
cord-264884-ydkigome	421	23	,	,	,
cord-264884-ydkigome	421	24	1998	1998	CD
cord-264884-ydkigome	421	25	)	)	-RRB-
cord-264884-ydkigome	421	26	.	.	.
cord-264884-ydkigome	422	1	The	the	DT
cord-264884-ydkigome	422	2	most	most	RBS
cord-264884-ydkigome	422	3	serious	serious	JJ
cord-264884-ydkigome	422	4	CNS	CNS	NNP
cord-264884-ydkigome	422	5	disease	disease	NN
cord-264884-ydkigome	422	6	is	be	VBZ
cord-264884-ydkigome	422	7	in	in	IN
cord-264884-ydkigome	422	8	S	s	NN
cord-264884-ydkigome	422	9	-	-	HYPH
cord-264884-ydkigome	422	10	gene	gene	NN
cord-264884-ydkigome	422	11	variant	variant	NN
cord-264884-ydkigome	422	12	of	of	IN
cord-264884-ydkigome	422	13	MHV-4	MHV-4	NNP
cord-264884-ydkigome	422	14	(	(	-LRB-
cord-264884-ydkigome	422	15	JHM	JHM	NNP
cord-264884-ydkigome	422	16	)	)	-RRB-
cord-264884-ydkigome	422	17	,	,	,
cord-264884-ydkigome	422	18	thus	thus	RB
cord-264884-ydkigome	422	19	as	as	IN
cord-264884-ydkigome	422	20	with	with	IN
cord-264884-ydkigome	422	21	the	the	DT
cord-264884-ydkigome	422	22	poliomouse	poliomouse	NNP
cord-264884-ydkigome	422	23	model	model	NN
cord-264884-ydkigome	422	24	,	,	,
cord-264884-ydkigome	422	25	pathogenic	pathogenic	JJ
cord-264884-ydkigome	422	26	fi	fi	NN
cord-264884-ydkigome	422	27	tness	tness	NN
cord-264884-ydkigome	422	28	with	with	IN
cord-264884-ydkigome	422	29	MHV	MHV	NNP
cord-264884-ydkigome	422	30	is	be	VBZ
cord-264884-ydkigome	422	31	also	also	RB
cord-264884-ydkigome	422	32	associated	associate	VBN
cord-264884-ydkigome	422	33	with	with	IN
cord-264884-ydkigome	422	34	quasispecies	quasispecie	NNS
cord-264884-ydkigome	422	35	.	.	.
cord-264884-ydkigome	423	1	Such	such	JJ
cord-264884-ydkigome	423	2	MHV	MHV	NNP
cord-264884-ydkigome	423	3	disease	disease	NN
cord-264884-ydkigome	423	4	is	be	VBZ
cord-264884-ydkigome	423	5	the	the	DT
cord-264884-ydkigome	423	6	bane	bane	NN
cord-264884-ydkigome	423	7	of	of	IN
cord-264884-ydkigome	423	8	all	all	DT
cord-264884-ydkigome	423	9	mouse	mouse	NN
cord-264884-ydkigome	423	10	colonies	colony	NNS
cord-264884-ydkigome	423	11	(	(	-LRB-
cord-264884-ydkigome	423	12	Knobler	Knobler	NNP
cord-264884-ydkigome	423	13	et	et	NNP
cord-264884-ydkigome	423	14	al	al	NNP
cord-264884-ydkigome	423	15	.	.	NNP
cord-264884-ydkigome	423	16	,	,	,
cord-264884-ydkigome	423	17	1982	1982	CD
cord-264884-ydkigome	423	18	)	)	-RRB-
cord-264884-ydkigome	423	19	.	.	.
cord-264884-ydkigome	424	1	However	however	RB
cord-264884-ydkigome	424	2	,	,	,
cord-264884-ydkigome	424	3	once	once	RB
cord-264884-ydkigome	424	4	MHV	MHV	NNP
cord-264884-ydkigome	424	5	persistence	persistence	NN
cord-264884-ydkigome	424	6	is	be	VBZ
cord-264884-ydkigome	424	7	attained	attain	VBN
cord-264884-ydkigome	424	8	,	,	,
cord-264884-ydkigome	424	9	the	the	DT
cord-264884-ydkigome	424	10	problem	problem	NN
cord-264884-ydkigome	424	11	to	to	IN
cord-264884-ydkigome	424	12	a	a	DT
cord-264884-ydkigome	424	13	mouse	mouse	NN
cord-264884-ydkigome	424	14	facility	facility	NN
cord-264884-ydkigome	424	15	is	be	VBZ
cord-264884-ydkigome	424	16	not	not	RB
cord-264884-ydkigome	424	17	due	due	JJ
cord-264884-ydkigome	424	18	to	to	IN
cord-264884-ydkigome	424	19	acute	acute	JJ
cord-264884-ydkigome	424	20	disease	disease	NN
cord-264884-ydkigome	424	21	,	,	,
cord-264884-ydkigome	424	22	but	but	CC
cord-264884-ydkigome	424	23	because	because	IN
cord-264884-ydkigome	424	24	immunological	immunological	JJ
cord-264884-ydkigome	424	25	measurements	measurement	NNS
cord-264884-ydkigome	424	26	are	be	VBP
cord-264884-ydkigome	424	27	signifi	signifi	NNP
cord-264884-ydkigome	424	28	cantly	cantly	RB
cord-264884-ydkigome	424	29	affected	affect	VBN
cord-264884-ydkigome	424	30	by	by	IN
cord-264884-ydkigome	424	31	MHV	MHV	NNP
cord-264884-ydkigome	424	32	persistence	persistence	NN
cord-264884-ydkigome	424	33	.	.	.
cord-264884-ydkigome	425	1	Thus	thus	RB
cord-264884-ydkigome	425	2	MHV	MHV	NNP
cord-264884-ydkigome	425	3	alters	alter	VBZ
cord-264884-ydkigome	425	4	mouse	mouse	NN
cord-264884-ydkigome	425	5	molecular	molecular	JJ
cord-264884-ydkigome	425	6	identity	identity	NN
cord-264884-ydkigome	425	7	regarding	regard	VBG
cord-264884-ydkigome	425	8	immunological	immunological	JJ
cord-264884-ydkigome	425	9	(	(	-LRB-
cord-264884-ydkigome	425	10	T	t	NN
cord-264884-ydkigome	425	11	-	-	HYPH
cord-264884-ydkigome	425	12	cell	cell	NN
cord-264884-ydkigome	425	13	)	)	-RRB-
cord-264884-ydkigome	425	14	reactions	reaction	NNS
cord-264884-ydkigome	425	15	(	(	-LRB-
cord-264884-ydkigome	425	16	Wilberz	Wilberz	NNP
cord-264884-ydkigome	425	17	et	et	FW
cord-264884-ydkigome	425	18	al	al	NNP
cord-264884-ydkigome	425	19	.	.	NNP
cord-264884-ydkigome	425	20	,	,	,
cord-264884-ydkigome	425	21	1991	1991	CD
cord-264884-ydkigome	425	22	)	)	-RRB-
cord-264884-ydkigome	425	23	.	.	.
cord-264884-ydkigome	426	1	To	to	TO
cord-264884-ydkigome	426	2	establish	establish	VB
cord-264884-ydkigome	426	3	stable	stable	JJ
cord-264884-ydkigome	426	4	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	426	5	persistence	persistence	NN
cord-264884-ydkigome	426	6	,	,	,
cord-264884-ydkigome	426	7	however	however	RB
cord-264884-ydkigome	426	8	,	,	,
cord-264884-ydkigome	426	9	MHV	MHV	NNP
cord-264884-ydkigome	426	10	needs	need	VBZ
cord-264884-ydkigome	426	11	to	to	TO
cord-264884-ydkigome	426	12	infect	infect	VB
cord-264884-ydkigome	426	13	newborns	newborn	NNS
cord-264884-ydkigome	426	14	(	(	-LRB-
cord-264884-ydkigome	426	15	Weir	Weir	NNP
cord-264884-ydkigome	426	16	et	et	NNP
cord-264884-ydkigome	426	17	al	al	NNP
cord-264884-ydkigome	426	18	.	.	NNP
cord-264884-ydkigome	426	19	,	,	,
cord-264884-ydkigome	426	20	1987	1987	CD
cord-264884-ydkigome	426	21	)	)	-RRB-
cord-264884-ydkigome	426	22	,	,	,
cord-264884-ydkigome	426	23	in	in	IN
cord-264884-ydkigome	426	24	which	which	WDT
cord-264884-ydkigome	426	25	acute	acute	JJ
cord-264884-ydkigome	426	26	disease	disease	NN
cord-264884-ydkigome	426	27	is	be	VBZ
cord-264884-ydkigome	426	28	prevented	prevent	VBN
cord-264884-ydkigome	426	29	due	due	IN
cord-264884-ydkigome	426	30	to	to	IN
cord-264884-ydkigome	426	31	maternal	maternal	JJ
cord-264884-ydkigome	426	32	passive	passive	JJ
cord-264884-ydkigome	426	33	immune	immune	JJ
cord-264884-ydkigome	426	34	antibody	antibody	NN
cord-264884-ydkigome	426	35	transfer	transfer	NN
cord-264884-ydkigome	426	36	(	(	-LRB-
cord-264884-ydkigome	426	37	Gustafsson	Gustafsson	NNP
cord-264884-ydkigome	426	38	et	et	NNP
cord-264884-ydkigome	426	39	al	al	NNP
cord-264884-ydkigome	426	40	.	.	NNP
cord-264884-ydkigome	426	41	,	,	,
cord-264884-ydkigome	426	42	1996	1996	CD
cord-264884-ydkigome	426	43	)	)	-RRB-
cord-264884-ydkigome	426	44	.	.	.
cord-264884-ydkigome	427	1	Being	be	VBG
cord-264884-ydkigome	427	2	born	bear	VBN
cord-264884-ydkigome	427	3	to	to	IN
cord-264884-ydkigome	427	4	immune	immune	JJ
cord-264884-ydkigome	427	5	mothers	mother	NNS
cord-264884-ydkigome	427	6	thus	thus	RB
cord-264884-ydkigome	427	7	protects	protect	VBZ
cord-264884-ydkigome	427	8	against	against	IN
cord-264884-ydkigome	427	9	CNS	CNS	NNP
cord-264884-ydkigome	427	10	disease	disease	NN
cord-264884-ydkigome	427	11	and	and	CC
cord-264884-ydkigome	427	12	promotes	promote	VBZ
cord-264884-ydkigome	427	13	enteric	enteric	JJ
cord-264884-ydkigome	427	14	(	(	-LRB-
cord-264884-ydkigome	427	15	not	not	RB
cord-264884-ydkigome	427	16	brain	brain	NN
cord-264884-ydkigome	427	17	)	)	-RRB-
cord-264884-ydkigome	427	18	virus	virus	NN
cord-264884-ydkigome	427	19	colonization	colonization	NN
cord-264884-ydkigome	427	20	.	.	.
cord-264884-ydkigome	428	1	In	in	IN
cord-264884-ydkigome	428	2	addition	addition	NN
cord-264884-ydkigome	428	3	,	,	,
cord-264884-ydkigome	428	4	it	-PRON-	PRP
cord-264884-ydkigome	428	5	appears	appear	VBZ
cord-264884-ydkigome	428	6	that	that	IN
cord-264884-ydkigome	428	7	persistence	persistence	NN
cord-264884-ydkigome	428	8	also	also	RB
cord-264884-ydkigome	428	9	promotes	promote	VBZ
cord-264884-ydkigome	428	10	cross	cross	NN
cord-264884-ydkigome	428	11	-	-	JJ
cord-264884-ydkigome	428	12	species	species	JJ
cord-264884-ydkigome	428	13	transfer	transfer	NN
cord-264884-ydkigome	428	14	(	(	-LRB-
cord-264884-ydkigome	428	15	Baric	Baric	NNP
cord-264884-ydkigome	428	16	et	et	NNP
cord-264884-ydkigome	428	17	al	al	NNP
cord-264884-ydkigome	428	18	.	.	NNP
cord-264884-ydkigome	428	19	,	,	,
cord-264884-ydkigome	428	20	1999	1999	CD
cord-264884-ydkigome	428	21	)	)	-RRB-
cord-264884-ydkigome	428	22	.	.	.
cord-264884-ydkigome	429	1	MHV	MHV	NNP
cord-264884-ydkigome	429	2	persistence	persistence	NN
cord-264884-ydkigome	429	3	may	may	MD
cord-264884-ydkigome	429	4	involve	involve	VB
cord-264884-ydkigome	429	5	genome	genome	NN
cord-264884-ydkigome	429	6	stability	stability	NN
cord-264884-ydkigome	429	7	and	and	CC
cord-264884-ydkigome	429	8	result	result	VB
cord-264884-ydkigome	429	9	in	in	IN
cord-264884-ydkigome	429	10	a	a	DT
cord-264884-ydkigome	429	11	distinct	distinct	JJ
cord-264884-ydkigome	429	12	evolutionary	evolutionary	JJ
cord-264884-ydkigome	429	13	dynamic	dynamic	NN
cord-264884-ydkigome	429	14	.	.	.
cord-264884-ydkigome	430	1	Asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	430	2	persisting	persist	VBG
cord-264884-ydkigome	430	3	infections	infection	NNS
cord-264884-ydkigome	430	4	in	in	IN
cord-264884-ydkigome	430	5	a	a	DT
cord-264884-ydkigome	430	6	Lewis	Lewis	NNP
cord-264884-ydkigome	430	7	rat	rat	NN
cord-264884-ydkigome	430	8	,	,	,
cord-264884-ydkigome	430	9	for	for	IN
cord-264884-ydkigome	430	10	example	example	NN
cord-264884-ydkigome	430	11	,	,	,
cord-264884-ydkigome	430	12	showed	show	VBD
cord-264884-ydkigome	430	13	no	no	DT
cord-264884-ydkigome	430	14	variation	variation	NN
cord-264884-ydkigome	430	15	in	in	IN
cord-264884-ydkigome	430	16	MHV	MHV	NNP
cord-264884-ydkigome	430	17	S	S	NNP
cord-264884-ydkigome	430	18	gene	gene	NN
cord-264884-ydkigome	430	19	sequence	sequence	NN
cord-264884-ydkigome	430	20	,	,	,
cord-264884-ydkigome	430	21	and	and	CC
cord-264884-ydkigome	430	22	no	no	DT
cord-264884-ydkigome	430	23	quasispecies	quasispecie	NNS
cord-264884-ydkigome	430	24	as	as	IN
cord-264884-ydkigome	430	25	seen	see	VBN
cord-264884-ydkigome	430	26	in	in	IN
cord-264884-ydkigome	430	27	brain	brain	NN
cord-264884-ydkigome	430	28	infections	infection	NNS
cord-264884-ydkigome	431	1	(	(	-LRB-
cord-264884-ydkigome	431	2	Stuhler	Stuhler	NNP
cord-264884-ydkigome	431	3	et	et	NNP
cord-264884-ydkigome	431	4	al	al	NNP
cord-264884-ydkigome	431	5	.	.	NNP
cord-264884-ydkigome	431	6	,	,	,
cord-264884-ydkigome	431	7	1997	1997	CD
cord-264884-ydkigome	431	8	)	)	-RRB-
cord-264884-ydkigome	431	9	.	.	.
cord-264884-ydkigome	432	1	The	the	DT
cord-264884-ydkigome	432	2	need	need	NN
cord-264884-ydkigome	432	3	to	to	TO
cord-264884-ydkigome	432	4	establish	establish	VB
cord-264884-ydkigome	432	5	stable	stable	JJ
cord-264884-ydkigome	432	6	persistence	persistence	NN
cord-264884-ydkigome	432	7	could	could	MD
cord-264884-ydkigome	432	8	then	then	RB
cord-264884-ydkigome	432	9	be	be	VB
cord-264884-ydkigome	432	10	providing	provide	VBG
cord-264884-ydkigome	432	11	a	a	DT
cord-264884-ydkigome	432	12	strong	strong	JJ
cord-264884-ydkigome	432	13	selection	selection	NN
cord-264884-ydkigome	432	14	for	for	IN
cord-264884-ydkigome	432	15	increased	increase	VBN
cord-264884-ydkigome	432	16	genome	genome	NN
cord-264884-ydkigome	432	17	complexity	complexity	NN
cord-264884-ydkigome	432	18	and	and	CC
cord-264884-ydkigome	432	19	stability	stability	NN
cord-264884-ydkigome	432	20	and	and	CC
cord-264884-ydkigome	432	21	might	may	MD
cord-264884-ydkigome	432	22	better	better	RB
cord-264884-ydkigome	432	23	explain	explain	VB
cord-264884-ydkigome	432	24	the	the	DT
cord-264884-ydkigome	432	25	selection	selection	NN
cord-264884-ydkigome	432	26	for	for	IN
cord-264884-ydkigome	432	27	the	the	DT
cord-264884-ydkigome	432	28	enhanced	enhance	VBN
cord-264884-ydkigome	432	29	RNA	RNA	NNP
cord-264884-ydkigome	432	30	polymerase	polymerase	NN
cord-264884-ydkigome	432	31	fi	fi	NN
cord-264884-ydkigome	432	32	delity	delity	NN
cord-264884-ydkigome	432	33	in	in	IN
cord-264884-ydkigome	432	34	nidoviruses	nidoviruse	NNS
cord-264884-ydkigome	432	35	.	.	.
cord-264884-ydkigome	433	1	How	how	WRB
cord-264884-ydkigome	433	2	might	may	MD
cord-264884-ydkigome	433	3	such	such	JJ
cord-264884-ydkigome	433	4	selection	selection	NN
cord-264884-ydkigome	433	5	operate	operate	VBP
cord-264884-ydkigome	433	6	in	in	IN
cord-264884-ydkigome	433	7	natural	natural	JJ
cord-264884-ydkigome	433	8	populations	population	NNS
cord-264884-ydkigome	433	9	?	?	.
cord-264884-ydkigome	434	1	Evolutionary	evolutionary	JJ
cord-264884-ydkigome	434	2	biologists	biologist	NNS
cord-264884-ydkigome	434	3	often	often	RB
cord-264884-ydkigome	434	4	consider	consider	VBP
cord-264884-ydkigome	434	5	what	what	WP
cord-264884-ydkigome	434	6	might	may	MD
cord-264884-ydkigome	434	7	differentiate	differentiate	VB
cord-264884-ydkigome	434	8	one	one	CD
cord-264884-ydkigome	434	9	group	group	NN
cord-264884-ydkigome	434	10	from	from	IN
cord-264884-ydkigome	434	11	another	another	DT
cord-264884-ydkigome	434	12	very	very	RB
cord-264884-ydkigome	434	13	similar	similar	JJ
cord-264884-ydkigome	434	14	group	group	NN
cord-264884-ydkigome	434	15	in	in	IN
cord-264884-ydkigome	434	16	a	a	DT
cord-264884-ydkigome	434	17	way	way	NN
cord-264884-ydkigome	434	18	that	that	WDT
cord-264884-ydkigome	434	19	leads	lead	VBZ
cord-264884-ydkigome	434	20	to	to	IN
cord-264884-ydkigome	434	21	two	two	CD
cord-264884-ydkigome	434	22	isolated	isolated	JJ
cord-264884-ydkigome	434	23	and	and	CC
cord-264884-ydkigome	434	24	distinct	distinct	JJ
cord-264884-ydkigome	434	25	populations	population	NNS
cord-264884-ydkigome	434	26	.	.	.
cord-264884-ydkigome	435	1	Consider	consider	VB
cord-264884-ydkigome	435	2	two	two	CD
cord-264884-ydkigome	435	3	hypothetical	hypothetical	JJ
cord-264884-ydkigome	435	4	adjacent	adjacent	JJ
cord-264884-ydkigome	435	5	hay	hay	NN
cord-264884-ydkigome	435	6	stacks	stack	NNS
cord-264884-ydkigome	435	7	harboring	harbor	VBG
cord-264884-ydkigome	435	8	two	two	CD
cord-264884-ydkigome	435	9	Mus	Mus	NNP
cord-264884-ydkigome	435	10	musculus	musculus	NN
cord-264884-ydkigome	435	11	colonies	colony	NNS
cord-264884-ydkigome	435	12	,	,	,
cord-264884-ydkigome	435	13	one	one	CD
cord-264884-ydkigome	435	14	of	of	IN
cord-264884-ydkigome	435	15	which	which	WDT
cord-264884-ydkigome	435	16	is	be	VBZ
cord-264884-ydkigome	435	17	persistently	persistently	RB
cord-264884-ydkigome	435	18	infected	infect	VBN
cord-264884-ydkigome	435	19	with	with	IN
cord-264884-ydkigome	435	20	MHV	MHV	NNP
cord-264884-ydkigome	435	21	the	the	DT
cord-264884-ydkigome	435	22	other	other	JJ
cord-264884-ydkigome	435	23	which	which	WDT
cord-264884-ydkigome	435	24	is	be	VBZ
cord-264884-ydkigome	435	25	not	not	RB
cord-264884-ydkigome	435	26	.	.	.
cord-264884-ydkigome	436	1	What	what	WP
cord-264884-ydkigome	436	2	is	be	VBZ
cord-264884-ydkigome	436	3	the	the	DT
cord-264884-ydkigome	436	4	fi	fi	XX
cord-264884-ydkigome	436	5	tness	tness	NN
cord-264884-ydkigome	436	6	consequence	consequence	NN
cord-264884-ydkigome	436	7	to	to	IN
cord-264884-ydkigome	436	8	the	the	DT
cord-264884-ydkigome	436	9	colony	colony	NN
cord-264884-ydkigome	436	10	harboring	harbor	VBG
cord-264884-ydkigome	436	11	MHV	MHV	NNP
cord-264884-ydkigome	436	12	relative	relative	JJ
cord-264884-ydkigome	436	13	to	to	IN
cord-264884-ydkigome	436	14	its	-PRON-	PRP$
cord-264884-ydkigome	436	15	uninfected	uninfected	JJ
cord-264884-ydkigome	436	16	neighbor	neighbor	NN
cord-264884-ydkigome	436	17	?	?	.
cord-264884-ydkigome	437	1	Our	-PRON-	PRP$
cord-264884-ydkigome	437	2	experience	experience	NN
cord-264884-ydkigome	437	3	with	with	IN
cord-264884-ydkigome	437	4	MHV	MHV	NNP
cord-264884-ydkigome	437	5	in	in	IN
cord-264884-ydkigome	437	6	mouse	mouse	NN
cord-264884-ydkigome	437	7	breeding	breeding	NN
cord-264884-ydkigome	437	8	colony	colony	NN
cord-264884-ydkigome	437	9	provides	provide	VBZ
cord-264884-ydkigome	437	10	a	a	DT
cord-264884-ydkigome	437	11	clear	clear	JJ
cord-264884-ydkigome	437	12	answer	answer	NN
cord-264884-ydkigome	437	13	.	.	.
cord-264884-ydkigome	438	1	The	the	DT
cord-264884-ydkigome	438	2	colony	colony	NN
cord-264884-ydkigome	438	3	that	that	WDT
cord-264884-ydkigome	438	4	is	be	VBZ
cord-264884-ydkigome	438	5	persistently	persistently	RB
cord-264884-ydkigome	438	6	infected	infect	VBN
cord-264884-ydkigome	438	7	with	with	IN
cord-264884-ydkigome	438	8	MHV	MHV	NNP
cord-264884-ydkigome	438	9	will	will	MD
cord-264884-ydkigome	438	10	have	have	VB
cord-264884-ydkigome	438	11	a	a	DT
cord-264884-ydkigome	438	12	distinct	distinct	JJ
cord-264884-ydkigome	438	13	advantage	advantage	NN
cord-264884-ydkigome	438	14	over	over	IN
cord-264884-ydkigome	438	15	its	-PRON-	PRP$
cord-264884-ydkigome	438	16	neighbor	neighbor	NN
cord-264884-ydkigome	438	17	as	as	IN
cord-264884-ydkigome	438	18	MHV	MHV	NNP
cord-264884-ydkigome	438	19	introduced	introduce	VBD
cord-264884-ydkigome	438	20	into	into	IN
cord-264884-ydkigome	438	21	this	this	DT
cord-264884-ydkigome	438	22	uninfected	uninfected	JJ
cord-264884-ydkigome	438	23	colony	colony	NN
cord-264884-ydkigome	438	24	will	will	MD
cord-264884-ydkigome	438	25	have	have	VB
cord-264884-ydkigome	438	26	severe	severe	JJ
cord-264884-ydkigome	438	27	effects	effect	NNS
cord-264884-ydkigome	438	28	on	on	IN
cord-264884-ydkigome	438	29	the	the	DT
cord-264884-ydkigome	438	30	offspring	offspring	NN
cord-264884-ydkigome	438	31	.	.	.
cord-264884-ydkigome	439	1	Eventually	eventually	RB
cord-264884-ydkigome	439	2	,	,	,
cord-264884-ydkigome	439	3	we	-PRON-	PRP
cord-264884-ydkigome	439	4	can	can	MD
cord-264884-ydkigome	439	5	expect	expect	VB
cord-264884-ydkigome	439	6	only	only	RB
cord-264884-ydkigome	439	7	the	the	DT
cord-264884-ydkigome	439	8	MHV	MHV	NNP
cord-264884-ydkigome	439	9	-	-	HYPH
cord-264884-ydkigome	439	10	harboring	harbor	VBG
cord-264884-ydkigome	439	11	colony	colony	NN
cord-264884-ydkigome	439	12	will	will	MD
cord-264884-ydkigome	439	13	prevail	prevail	VB
cord-264884-ydkigome	439	14	in	in	IN
cord-264884-ydkigome	439	15	both	both	DT
cord-264884-ydkigome	439	16	hay	hay	NN
cord-264884-ydkigome	439	17	stacks	stack	NNS
cord-264884-ydkigome	439	18	.	.	.
cord-264884-ydkigome	440	1	This	this	DT
cord-264884-ydkigome	440	2	is	be	VBZ
cord-264884-ydkigome	440	3	a	a	DT
cord-264884-ydkigome	440	4	state	state	NN
cord-264884-ydkigome	440	5	I	-PRON-	PRP
cord-264884-ydkigome	440	6	have	have	VBP
cord-264884-ydkigome	440	7	called	call	VBN
cord-264884-ydkigome	440	8	virus	virus	NN
cord-264884-ydkigome	440	9	addiction	addiction	NN
cord-264884-ydkigome	440	10	.	.	.
cord-264884-ydkigome	441	1	Only	only	RB
cord-264884-ydkigome	441	2	mice	mouse	NNS
cord-264884-ydkigome	441	3	harboring	harbor	VBG
cord-264884-ydkigome	441	4	persistent	persistent	JJ
cord-264884-ydkigome	441	5	MHV	MHV	NNP
cord-264884-ydkigome	441	6	are	be	VBP
cord-264884-ydkigome	441	7	protected	protect	VBN
cord-264884-ydkigome	441	8	against	against	IN
cord-264884-ydkigome	441	9	the	the	DT
cord-264884-ydkigome	441	10	potential	potential	JJ
cord-264884-ydkigome	441	11	pathogenic	pathogenic	JJ
cord-264884-ydkigome	441	12	consequence	consequence	NN
cord-264884-ydkigome	441	13	of	of	IN
cord-264884-ydkigome	441	14	acute	acute	JJ
cord-264884-ydkigome	441	15	MHV	MHV	NNP
cord-264884-ydkigome	441	16	(	(	-LRB-
cord-264884-ydkigome	441	17	or	or	CC
cord-264884-ydkigome	441	18	related	related	JJ
cord-264884-ydkigome	441	19	virus	virus	NN
cord-264884-ydkigome	441	20	)	)	-RRB-
cord-264884-ydkigome	441	21	infection	infection	NN
cord-264884-ydkigome	441	22	.	.	.
cord-264884-ydkigome	442	1	The	the	DT
cord-264884-ydkigome	442	2	population	population	NN
cord-264884-ydkigome	442	3	is	be	VBZ
cord-264884-ydkigome	442	4	addicted	addict	VBN
cord-264884-ydkigome	442	5	to	to	IN
cord-264884-ydkigome	442	6	the	the	DT
cord-264884-ydkigome	442	7	virus	virus	NN
cord-264884-ydkigome	442	8	.	.	.
cord-264884-ydkigome	443	1	Such	such	JJ
cord-264884-ydkigome	443	2	a	a	DT
cord-264884-ydkigome	443	3	state	state	NN
cord-264884-ydkigome	443	4	,	,	,
cord-264884-ydkigome	443	5	however	however	RB
cord-264884-ydkigome	443	6	,	,	,
cord-264884-ydkigome	443	7	is	be	VBZ
cord-264884-ydkigome	443	8	clearly	clearly	RB
cord-264884-ydkigome	443	9	affecting	affect	VBG
cord-264884-ydkigome	443	10	colonies	colony	NNS
cord-264884-ydkigome	443	11	(	(	-LRB-
cord-264884-ydkigome	443	12	or	or	CC
cord-264884-ydkigome	443	13	groups	group	NNS
cord-264884-ydkigome	443	14	)	)	-RRB-
cord-264884-ydkigome	443	15	of	of	IN
cord-264884-ydkigome	443	16	host	host	NN
cord-264884-ydkigome	443	17	,	,	,
cord-264884-ydkigome	443	18	not	not	RB
cord-264884-ydkigome	443	19	individuals	individual	NNS
cord-264884-ydkigome	443	20	.	.	.
cord-264884-ydkigome	444	1	An	an	DT
cord-264884-ydkigome	444	2	individual	individual	NN
cord-264884-ydkigome	444	3	either	either	CC
cord-264884-ydkigome	444	4	quickly	quickly	RB
cord-264884-ydkigome	444	5	succumbs	succumb	VBZ
cord-264884-ydkigome	444	6	to	to	IN
cord-264884-ydkigome	444	7	the	the	DT
cord-264884-ydkigome	444	8	virus	virus	NN
cord-264884-ydkigome	444	9	infection	infection	NN
cord-264884-ydkigome	444	10	or	or	CC
cord-264884-ydkigome	444	11	,	,	,
cord-264884-ydkigome	444	12	if	if	IN
cord-264884-ydkigome	444	13	infected	infect	VBN
cord-264884-ydkigome	444	14	,	,	,
cord-264884-ydkigome	444	15	transmits	transmit	VBZ
cord-264884-ydkigome	444	16	it	-PRON-	PRP
cord-264884-ydkigome	444	17	to	to	IN
cord-264884-ydkigome	444	18	others	other	NNS
cord-264884-ydkigome	444	19	in	in	IN
cord-264884-ydkigome	444	20	the	the	DT
cord-264884-ydkigome	444	21	colony	colony	NN
cord-264884-ydkigome	444	22	.	.	.
cord-264884-ydkigome	445	1	A	a	DT
cord-264884-ydkigome	445	2	colony	colony	NN
cord-264884-ydkigome	445	3	is	be	VBZ
cord-264884-ydkigome	445	4	thus	thus	RB
cord-264884-ydkigome	445	5	under	under	IN
cord-264884-ydkigome	445	6	selection	selection	NN
cord-264884-ydkigome	445	7	by	by	IN
cord-264884-ydkigome	445	8	MHV	MHV	NNP
cord-264884-ydkigome	445	9	.	.	.
cord-264884-ydkigome	446	1	To	to	TO
cord-264884-ydkigome	446	2	generalize	generalize	VB
cord-264884-ydkigome	446	3	this	this	DT
cord-264884-ydkigome	446	4	state	state	NN
cord-264884-ydkigome	446	5	,	,	,
cord-264884-ydkigome	446	6	we	-PRON-	PRP
cord-264884-ydkigome	446	7	expect	expect	VBP
cord-264884-ydkigome	446	8	that	that	IN
cord-264884-ydkigome	446	9	the	the	DT
cord-264884-ydkigome	446	10	persistence	persistence	NN
cord-264884-ydkigome	446	11	of	of	IN
cord-264884-ydkigome	446	12	SARS	SARS	NNP
cord-264884-ydkigome	446	13	in	in	IN
cord-264884-ydkigome	446	14	specifi	specifi	NNP
cord-264884-ydkigome	446	15	c	c	NN
cord-264884-ydkigome	446	16	bat	bat	NN
cord-264884-ydkigome	446	17	populations	population	NNS
cord-264884-ydkigome	446	18	would	would	MD
cord-264884-ydkigome	446	19	be	be	VB
cord-264884-ydkigome	446	20	expected	expect	VBN
cord-264884-ydkigome	446	21	to	to	TO
cord-264884-ydkigome	446	22	also	also	RB
cord-264884-ydkigome	446	23	affect	affect	VB
cord-264884-ydkigome	446	24	the	the	DT
cord-264884-ydkigome	446	25	fi	fi	XX
cord-264884-ydkigome	446	26	tness	tness	NN
cord-264884-ydkigome	446	27	of	of	IN
cord-264884-ydkigome	446	28	the	the	DT
cord-264884-ydkigome	446	29	corresponding	correspond	VBG
cord-264884-ydkigome	446	30	specifi	specifi	NN
cord-264884-ydkigome	446	31	c	c	NN
cord-264884-ydkigome	446	32	bat	bat	NN
cord-264884-ydkigome	446	33	populations	population	NNS
cord-264884-ydkigome	446	34	.	.	.
cord-264884-ydkigome	447	1	Persistence	persistence	NN
cord-264884-ydkigome	447	2	is	be	VBZ
cord-264884-ydkigome	447	3	a	a	DT
cord-264884-ydkigome	447	4	more	more	RBR
cord-264884-ydkigome	447	5	demanding	demanding	JJ
cord-264884-ydkigome	447	6	phenotype	phenotype	NN
cord-264884-ydkigome	447	7	than	than	IN
cord-264884-ydkigome	447	8	acute	acute	JJ
cord-264884-ydkigome	447	9	replication	replication	NN
cord-264884-ydkigome	447	10	.	.	.
cord-264884-ydkigome	448	1	It	-PRON-	PRP
cord-264884-ydkigome	448	2	requires	require	VBZ
cord-264884-ydkigome	448	3	greater	great	JJR
cord-264884-ydkigome	448	4	gene	gene	NN
cord-264884-ydkigome	448	5	complexity	complexity	NN
cord-264884-ydkigome	448	6	to	to	TO
cord-264884-ydkigome	448	7	counter	counter	VB
cord-264884-ydkigome	448	8	host	host	NN
cord-264884-ydkigome	448	9	immunity	immunity	NN
cord-264884-ydkigome	448	10	and	and	CC
cord-264884-ydkigome	448	11	also	also	RB
cord-264884-ydkigome	448	12	to	to	TO
cord-264884-ydkigome	448	13	promote	promote	VB
cord-264884-ydkigome	448	14	self	self	NN
cord-264884-ydkigome	448	15	-	-	HYPH
cord-264884-ydkigome	448	16	regulation	regulation	NN
cord-264884-ydkigome	448	17	.	.	.
cord-264884-ydkigome	449	1	Thus	thus	RB
cord-264884-ydkigome	449	2	the	the	DT
cord-264884-ydkigome	449	3	enhanced	enhanced	JJ
cord-264884-ydkigome	449	4	fi	fi	NN
cord-264884-ydkigome	449	5	delity	delity	NN
cord-264884-ydkigome	449	6	of	of	IN
cord-264884-ydkigome	449	7	RNA	RNA	NNP
cord-264884-ydkigome	449	8	replication	replication	NN
cord-264884-ydkigome	449	9	is	be	VBZ
cord-264884-ydkigome	449	10	selected	select	VBN
cord-264884-ydkigome	449	11	in	in	IN
cord-264884-ydkigome	449	12	order	order	NN
cord-264884-ydkigome	449	13	to	to	TO
cord-264884-ydkigome	449	14	conserve	conserve	VB
cord-264884-ydkigome	449	15	this	this	DT
cord-264884-ydkigome	449	16	greater	great	JJR
cord-264884-ydkigome	449	17	genetic	genetic	JJ
cord-264884-ydkigome	449	18	complexity	complexity	NN
cord-264884-ydkigome	449	19	and	and	CC
cord-264884-ydkigome	449	20	stability	stability	NN
cord-264884-ydkigome	449	21	.	.	.
cord-264884-ydkigome	450	1	We	-PRON-	PRP
cord-264884-ydkigome	450	2	know	know	VBP
cord-264884-ydkigome	450	3	that	that	IN
cord-264884-ydkigome	450	4	the	the	DT
cord-264884-ydkigome	450	5	high	high	JJ
cord-264884-ydkigome	450	6	-	-	HYPH
cord-264884-ydkigome	450	7	fi	fi	NN
cord-264884-ydkigome	450	8	delity	delity	NN
cord-264884-ydkigome	450	9	RNA	RNA	NNP
cord-264884-ydkigome	450	10	replication	replication	NN
cord-264884-ydkigome	450	11	system	system	NN
cord-264884-ydkigome	450	12	(	(	-LRB-
cord-264884-ydkigome	450	13	including	include	VBG
cord-264884-ydkigome	450	14	RNA	RNA	NNP
cord-264884-ydkigome	450	15	pol	pol	NN
cord-264884-ydkigome	450	16	,	,	,
cord-264884-ydkigome	450	17	helicase	helicase	NNP
cord-264884-ydkigome	450	18	,	,	,
cord-264884-ydkigome	450	19	endoribonuclease	endoribonuclease	NN
cord-264884-ydkigome	450	20	,	,	,
cord-264884-ydkigome	450	21	and	and	CC
cord-264884-ydkigome	450	22	other	other	JJ
cord-264884-ydkigome	450	23	activities	activity	NNS
cord-264884-ydkigome	450	24	)	)	-RRB-
cord-264884-ydkigome	450	25	is	be	VBZ
cord-264884-ydkigome	450	26	also	also	RB
cord-264884-ydkigome	450	27	present	present	JJ
cord-264884-ydkigome	450	28	in	in	IN
cord-264884-ydkigome	450	29	an	an	DT
cord-264884-ydkigome	450	30	ancient	ancient	JJ
cord-264884-ydkigome	450	31	nidovirus	nidovirus	NN
cord-264884-ydkigome	450	32	relative	relative	NN
cord-264884-ydkigome	450	33	of	of	IN
cord-264884-ydkigome	450	34	coronaviruses	coronaviruse	NNS
cord-264884-ydkigome	450	35	,	,	,
cord-264884-ydkigome	450	36	such	such	JJ
cord-264884-ydkigome	450	37	as	as	IN
cord-264884-ydkigome	450	38	fi	fi	NNP
cord-264884-ydkigome	450	39	sh	sh	RB
cord-264884-ydkigome	450	40	-	-	HYPH
cord-264884-ydkigome	450	41	isolated	isolate	VBN
cord-264884-ydkigome	450	42	white	white	JJ
cord-264884-ydkigome	450	43	bream	bream	NN
cord-264884-ydkigome	450	44	virus	virus	NN
cord-264884-ydkigome	450	45	(	(	-LRB-
cord-264884-ydkigome	450	46	26	26	CD
cord-264884-ydkigome	450	47	kb	kb	NNP
cord-264884-ydkigome	450	48	RNA	RNA	NNP
cord-264884-ydkigome	450	49	)	)	-RRB-
cord-264884-ydkigome	450	50	.	.	.
cord-264884-ydkigome	451	1	I	-PRON-	PRP
cord-264884-ydkigome	451	2	suggest	suggest	VBP
cord-264884-ydkigome	451	3	there	there	EX
cord-264884-ydkigome	451	4	will	will	MD
cord-264884-ydkigome	451	5	also	also	RB
cord-264884-ydkigome	451	6	likely	likely	RB
cord-264884-ydkigome	451	7	be	be	VB
cord-264884-ydkigome	451	8	species	species	NN
cord-264884-ydkigome	451	9	-	-	HYPH
cord-264884-ydkigome	451	10	specifi	specifi	NN
cord-264884-ydkigome	451	11	c	c	NN
cord-264884-ydkigome	451	12	persistent	persistent	JJ
cord-264884-ydkigome	451	13	infections	infection	NNS
cord-264884-ydkigome	451	14	with	with	IN
cord-264884-ydkigome	451	15	this	this	DT
cord-264884-ydkigome	451	16	virus	virus	NN
cord-264884-ydkigome	451	17	that	that	WDT
cord-264884-ydkigome	451	18	require	require	VBP
cord-264884-ydkigome	451	19	this	this	DT
cord-264884-ydkigome	451	20	enhanced	enhance	VBN
cord-264884-ydkigome	451	21	replication	replication	NN
cord-264884-ydkigome	451	22	fi	fi	NN
cord-264884-ydkigome	451	23	delity	delity	NN
cord-264884-ydkigome	451	24	and	and	CC
cord-264884-ydkigome	451	25	maintain	maintain	VB
cord-264884-ydkigome	451	26	this	this	DT
cord-264884-ydkigome	451	27	virus	virus	NN
cord-264884-ydkigome	451	28	in	in	IN
cord-264884-ydkigome	451	29	its	-PRON-	PRP$
cord-264884-ydkigome	451	30	natural	natural	JJ
cord-264884-ydkigome	451	31	habitat	habitat	NN
cord-264884-ydkigome	451	32	.	.	.
cord-264884-ydkigome	452	1	Thus	thus	RB
cord-264884-ydkigome	452	2	,	,	,
cord-264884-ydkigome	452	3	I	-PRON-	PRP
cord-264884-ydkigome	452	4	suggest	suggest	VBP
cord-264884-ydkigome	452	5	,	,	,
cord-264884-ydkigome	452	6	an	an	DT
cord-264884-ydkigome	452	7	ancient	ancient	JJ
cord-264884-ydkigome	452	8	persistent	persistent	JJ
cord-264884-ydkigome	452	9	life	life	NN
cord-264884-ydkigome	452	10	strategy	strategy	NN
cord-264884-ydkigome	452	11	could	could	MD
cord-264884-ydkigome	452	12	more	more	RBR
cord-264884-ydkigome	452	13	easily	easily	RB
cord-264884-ydkigome	452	14	explain	explain	VB
cord-264884-ydkigome	452	15	the	the	DT
cord-264884-ydkigome	452	16	monophyletic	monophyletic	JJ
cord-264884-ydkigome	452	17	character	character	NN
cord-264884-ydkigome	452	18	of	of	IN
cord-264884-ydkigome	452	19	the	the	DT
cord-264884-ydkigome	452	20	nidovirus	nidovirus	NNP
cord-264884-ydkigome	452	21	virus	virus	NN
cord-264884-ydkigome	452	22	lineage	lineage	NN
cord-264884-ydkigome	452	23	.	.	.
cord-264884-ydkigome	453	1	It	-PRON-	PRP
cord-264884-ydkigome	453	2	is	be	VBZ
cord-264884-ydkigome	453	3	particularly	particularly	RB
cord-264884-ydkigome	453	4	interesting	interesting	JJ
cord-264884-ydkigome	453	5	that	that	IN
cord-264884-ydkigome	453	6	one	one	CD
cord-264884-ydkigome	453	7	of	of	IN
cord-264884-ydkigome	453	8	these	these	DT
cord-264884-ydkigome	453	9	unique	unique	JJ
cord-264884-ydkigome	453	10	and	and	CC
cord-264884-ydkigome	453	11	conserved	conserved	JJ
cord-264884-ydkigome	453	12	replication	replication	NN
cord-264884-ydkigome	453	13	proteins	protein	NNS
cord-264884-ydkigome	453	14	(	(	-LRB-
cord-264884-ydkigome	453	15	ADP	ADP	NNP
cord-264884-ydkigome	453	16	ribose-1-monophosphate	ribose-1-monophosphate	NNP
cord-264884-ydkigome	453	17	)	)	-RRB-
cord-264884-ydkigome	453	18	is	be	VBZ
cord-264884-ydkigome	453	19	dispensable	dispensable	JJ
cord-264884-ydkigome	453	20	for	for	IN
cord-264884-ydkigome	453	21	culture	culture	NN
cord-264884-ydkigome	453	22	growth	growth	NN
cord-264884-ydkigome	453	23	(	(	-LRB-
cord-264884-ydkigome	453	24	Putics	Putics	NNP
cord-264884-ydkigome	453	25	et	et	NNP
cord-264884-ydkigome	453	26	al	al	NNP
cord-264884-ydkigome	453	27	.	.	NNP
cord-264884-ydkigome	453	28	,	,	,
cord-264884-ydkigome	453	29	2005	2005	CD
cord-264884-ydkigome	453	30	)	)	-RRB-
cord-264884-ydkigome	453	31	.	.	.
cord-264884-ydkigome	454	1	I	-PRON-	PRP
cord-264884-ydkigome	454	2	suggest	suggest	VBP
cord-264884-ydkigome	454	3	it	-PRON-	PRP
cord-264884-ydkigome	454	4	will	will	MD
cord-264884-ydkigome	454	5	not	not	RB
cord-264884-ydkigome	454	6	be	be	VB
cord-264884-ydkigome	454	7	dispensable	dispensable	JJ
cord-264884-ydkigome	454	8	for	for	IN
cord-264884-ydkigome	454	9	persistence	persistence	NN
cord-264884-ydkigome	454	10	.	.	.
cord-264884-ydkigome	455	1	The	the	DT
cord-264884-ydkigome	455	2	HIV-1	HIV-1	NNP
cord-264884-ydkigome	455	3	pandemic	pandemic	NN
cord-264884-ydkigome	455	4	is	be	VBZ
cord-264884-ydkigome	455	5	an	an	DT
cord-264884-ydkigome	455	6	unfi	unfi	NNP
cord-264884-ydkigome	455	7	nished	nishe	VBN
cord-264884-ydkigome	455	8	story	story	NN
cord-264884-ydkigome	455	9	.	.	.
cord-264884-ydkigome	456	1	HIV-1	HIV-1	NNP
cord-264884-ydkigome	456	2	represents	represent	VBZ
cord-264884-ydkigome	456	3	a	a	DT
cord-264884-ydkigome	456	4	real	real	JJ
cord-264884-ydkigome	456	5	-	-	HYPH
cord-264884-ydkigome	456	6	time	time	NN
cord-264884-ydkigome	456	7	biological	biological	JJ
cord-264884-ydkigome	456	8	event	event	NN
cord-264884-ydkigome	456	9	in	in	IN
cord-264884-ydkigome	456	10	human	human	JJ
cord-264884-ydkigome	456	11	evolution	evolution	NN
cord-264884-ydkigome	456	12	that	that	WDT
cord-264884-ydkigome	456	13	confi	confi	NNP
cord-264884-ydkigome	456	14	rms	rms	NNP
cord-264884-ydkigome	456	15	for	for	IN
cord-264884-ydkigome	456	16	us	-PRON-	PRP
cord-264884-ydkigome	456	17	the	the	DT
cord-264884-ydkigome	456	18	importance	importance	NN
cord-264884-ydkigome	456	19	of	of	IN
cord-264884-ydkigome	456	20	quasispecies	quasispecie	NNS
cord-264884-ydkigome	456	21	and	and	CC
cord-264884-ydkigome	456	22	retroviruses	retrovirus	NNS
cord-264884-ydkigome	456	23	to	to	IN
cord-264884-ydkigome	456	24	human	human	JJ
cord-264884-ydkigome	456	25	biology	biology	NN
cord-264884-ydkigome	456	26	.	.	.
cord-264884-ydkigome	457	1	However	however	RB
cord-264884-ydkigome	457	2	,	,	,
cord-264884-ydkigome	457	3	even	even	RB
cord-264884-ydkigome	457	4	though	though	IN
cord-264884-ydkigome	457	5	its	-PRON-	PRP$
cord-264884-ydkigome	457	6	human	human	JJ
cord-264884-ydkigome	457	7	toll	toll	NN
cord-264884-ydkigome	457	8	is	be	VBZ
cord-264884-ydkigome	457	9	huge	huge	JJ
cord-264884-ydkigome	457	10	,	,	,
cord-264884-ydkigome	457	11	modern	modern	JJ
cord-264884-ydkigome	457	12	medicine	medicine	NN
cord-264884-ydkigome	457	13	and	and	CC
cord-264884-ydkigome	457	14	culture	culture	NN
cord-264884-ydkigome	457	15	has	have	VBZ
cord-264884-ydkigome	457	16	responded	respond	VBN
cord-264884-ydkigome	457	17	rapidly	rapidly	RB
cord-264884-ydkigome	457	18	enough	enough	RB
cord-264884-ydkigome	457	19	to	to	TO
cord-264884-ydkigome	457	20	limit	limit	VB
cord-264884-ydkigome	457	21	the	the	DT
cord-264884-ydkigome	457	22	impact	impact	NN
cord-264884-ydkigome	457	23	of	of	IN
cord-264884-ydkigome	457	24	HIV-1	HIV-1	NNP
cord-264884-ydkigome	457	25	to	to	IN
cord-264884-ydkigome	457	26	the	the	DT
cord-264884-ydkigome	457	27	point	point	NN
cord-264884-ydkigome	457	28	at	at	IN
cord-264884-ydkigome	457	29	which	which	WDT
cord-264884-ydkigome	457	30	it	-PRON-	PRP
cord-264884-ydkigome	457	31	will	will	MD
cord-264884-ydkigome	457	32	not	not	RB
cord-264884-ydkigome	457	33	likely	likely	RB
cord-264884-ydkigome	457	34	be	be	VB
cord-264884-ydkigome	457	35	the	the	DT
cord-264884-ydkigome	457	36	cause	cause	NN
cord-264884-ydkigome	457	37	of	of	IN
cord-264884-ydkigome	457	38	a	a	DT
cord-264884-ydkigome	457	39	selective	selective	JJ
cord-264884-ydkigome	457	40	evolutionary	evolutionary	JJ
cord-264884-ydkigome	457	41	sweep	sweep	NN
cord-264884-ydkigome	457	42	that	that	WDT
cord-264884-ydkigome	457	43	could	could	MD
cord-264884-ydkigome	457	44	have	have	VB
cord-264884-ydkigome	457	45	altered	alter	VBN
cord-264884-ydkigome	457	46	human	human	JJ
cord-264884-ydkigome	457	47	genetic	genetic	JJ
cord-264884-ydkigome	457	48	makeup	makeup	NN
cord-264884-ydkigome	457	49	(	(	-LRB-
cord-264884-ydkigome	457	50	in	in	IN
cord-264884-ydkigome	457	51	contrast	contrast	NN
cord-264884-ydkigome	457	52	to	to	IN
cord-264884-ydkigome	457	53	the	the	DT
cord-264884-ydkigome	457	54	koala	koala	NNP
cord-264884-ydkigome	457	55	bear	bear	NNP
cord-264884-ydkigome	457	56	endogenization	endogenization	NNP
cord-264884-ydkigome	457	57	presented	present	VBN
cord-264884-ydkigome	457	58	below	below	RB
cord-264884-ydkigome	457	59	)	)	-RRB-
cord-264884-ydkigome	457	60	.	.	.
cord-264884-ydkigome	458	1	As	as	IN
cord-264884-ydkigome	458	2	described	describe	VBN
cord-264884-ydkigome	458	3	earlier	early	RBR
cord-264884-ydkigome	458	4	,	,	,
cord-264884-ydkigome	458	5	its	-PRON-	PRP$
cord-264884-ydkigome	458	6	amazing	amazing	JJ
cord-264884-ydkigome	458	7	adaptability	adaptability	NN
cord-264884-ydkigome	458	8	via	via	IN
cord-264884-ydkigome	458	9	quasispecies	quasispecie	NNS
cord-264884-ydkigome	458	10	along	along	IN
cord-264884-ydkigome	458	11	with	with	IN
cord-264884-ydkigome	458	12	extensive	extensive	JJ
cord-264884-ydkigome	458	13	recombination	recombination	NN
cord-264884-ydkigome	458	14	contribute	contribute	VBP
cord-264884-ydkigome	458	15	directly	directly	RB
cord-264884-ydkigome	458	16	to	to	IN
cord-264884-ydkigome	458	17	HIV-1	HIV-1	NNP
cord-264884-ydkigome	458	18	'	'	POS
cord-264884-ydkigome	458	19	s	s	NN
cord-264884-ydkigome	458	20	diversity	diversity	NN
cord-264884-ydkigome	458	21	and	and	CC
cord-264884-ydkigome	458	22	makes	make	VBZ
cord-264884-ydkigome	458	23	it	-PRON-	PRP
cord-264884-ydkigome	458	24	the	the	DT
cord-264884-ydkigome	458	25	most	most	RBS
cord-264884-ydkigome	458	26	dynamic	dynamic	JJ
cord-264884-ydkigome	458	27	genetic	genetic	JJ
cord-264884-ydkigome	458	28	entity	entity	NN
cord-264884-ydkigome	458	29	ever	ever	RB
cord-264884-ydkigome	458	30	studied	study	VBN
cord-264884-ydkigome	458	31	.	.	.
cord-264884-ydkigome	459	1	Many	many	JJ
cord-264884-ydkigome	459	2	studies	study	NNS
cord-264884-ydkigome	459	3	track	track	VBP
cord-264884-ydkigome	459	4	the	the	DT
cord-264884-ydkigome	459	5	dominant	dominant	JJ
cord-264884-ydkigome	459	6	HIV	HIV	NNP
cord-264884-ydkigome	459	7	population	population	NN
cord-264884-ydkigome	459	8	and	and	CC
cord-264884-ydkigome	459	9	fail	fail	VB
cord-264884-ydkigome	459	10	to	to	TO
cord-264884-ydkigome	459	11	examine	examine	VB
cord-264884-ydkigome	459	12	minority	minority	NN
cord-264884-ydkigome	459	13	populations	population	NNS
cord-264884-ydkigome	459	14	.	.	.
cord-264884-ydkigome	460	1	Yet	yet	CC
cord-264884-ydkigome	460	2	it	-PRON-	PRP
cord-264884-ydkigome	460	3	is	be	VBZ
cord-264884-ydkigome	460	4	precisely	precisely	RB
cord-264884-ydkigome	460	5	these	these	DT
cord-264884-ydkigome	460	6	minority	minority	NN
cord-264884-ydkigome	460	7	populations	population	NNS
cord-264884-ydkigome	460	8	,	,	,
cord-264884-ydkigome	460	9	which	which	WDT
cord-264884-ydkigome	460	10	evolve	evolve	VBP
cord-264884-ydkigome	460	11	independently	independently	RB
cord-264884-ydkigome	460	12	of	of	IN
cord-264884-ydkigome	460	13	the	the	DT
cord-264884-ydkigome	460	14	majority	majority	NN
cord-264884-ydkigome	460	15	population	population	NN
cord-264884-ydkigome	460	16	,	,	,
cord-264884-ydkigome	460	17	that	that	WDT
cord-264884-ydkigome	460	18	can	can	MD
cord-264884-ydkigome	460	19	determine	determine	VB
cord-264884-ydkigome	460	20	drug	drug	NN
cord-264884-ydkigome	460	21	resistance	resistance	NN
cord-264884-ydkigome	460	22	phenotype	phenotype	NN
cord-264884-ydkigome	460	23	and	and	CC
cord-264884-ydkigome	460	24	biological	biological	JJ
cord-264884-ydkigome	460	25	outcome	outcome	NN
cord-264884-ydkigome	461	1	(	(	-LRB-
cord-264884-ydkigome	461	2	Charpentier	Charpentier	NNP
cord-264884-ydkigome	461	3	et	et	NNP
cord-264884-ydkigome	461	4	al	al	NNP
cord-264884-ydkigome	461	5	.	.	NNP
cord-264884-ydkigome	461	6	,	,	,
cord-264884-ydkigome	461	7	2004	2004	CD
cord-264884-ydkigome	462	1	;	;	:
cord-264884-ydkigome	462	2	Briones	Briones	NNP
cord-264884-ydkigome	462	3	et	et	NNP
cord-264884-ydkigome	462	4	al	al	NNP
cord-264884-ydkigome	462	5	.	.	NNP
cord-264884-ydkigome	462	6	,	,	,
cord-264884-ydkigome	462	7	2006	2006	CD
cord-264884-ydkigome	462	8	;	;	:
cord-264884-ydkigome	462	9	Morand	Morand	NNP
cord-264884-ydkigome	462	10	-	-	HYPH
cord-264884-ydkigome	462	11	Joubert	Joubert	NNP
cord-264884-ydkigome	462	12	et	et	NNP
cord-264884-ydkigome	462	13	al	al	NNP
cord-264884-ydkigome	462	14	.	.	NNP
cord-264884-ydkigome	462	15	,	,	,
cord-264884-ydkigome	462	16	2006	2006	CD
cord-264884-ydkigome	462	17	)	)	-RRB-
cord-264884-ydkigome	462	18	.	.	.
cord-264884-ydkigome	463	1	Clearly	clearly	RB
cord-264884-ydkigome	463	2	,	,	,
cord-264884-ydkigome	463	3	the	the	DT
cord-264884-ydkigome	463	4	specifi	specifi	NNP
cord-264884-ydkigome	463	5	c	c	NNP
cord-264884-ydkigome	463	6	makeup	makeup	NN
cord-264884-ydkigome	463	7	of	of	IN
cord-264884-ydkigome	463	8	a	a	DT
cord-264884-ydkigome	463	9	complex	complex	JJ
cord-264884-ydkigome	463	10	HIV	HIV	NNP
cord-264884-ydkigome	463	11	population	population	NN
cord-264884-ydkigome	463	12	matters	matter	VBZ
cord-264884-ydkigome	463	13	.	.	.
cord-264884-ydkigome	464	1	Furthermore	furthermore	RB
cord-264884-ydkigome	464	2	,	,	,
cord-264884-ydkigome	464	3	HIV	HIV	NNP
cord-264884-ydkigome	464	4	defectives	defective	NNS
cord-264884-ydkigome	464	5	and	and	CC
cord-264884-ydkigome	464	6	variants	variant	NNS
cord-264884-ydkigome	464	7	can	can	MD
cord-264884-ydkigome	464	8	also	also	RB
cord-264884-ydkigome	464	9	have	have	VB
cord-264884-ydkigome	464	10	major	major	JJ
cord-264884-ydkigome	464	11	consequences	consequence	NNS
cord-264884-ydkigome	464	12	.	.	.
cord-264884-ydkigome	465	1	In	in	IN
cord-264884-ydkigome	465	2	some	some	DT
cord-264884-ydkigome	465	3	cases	case	NNS
cord-264884-ydkigome	465	4	,	,	,
cord-264884-ydkigome	465	5	long	long	JJ
cord-264884-ydkigome	465	6	-	-	HYPH
cord-264884-ydkigome	465	7	term	term	NN
cord-264884-ydkigome	465	8	non	non	NNS
cord-264884-ydkigome	465	9	-	-	NNS
cord-264884-ydkigome	465	10	progressors	progressor	NNS
cord-264884-ydkigome	465	11	of	of	IN
cord-264884-ydkigome	465	12	HIV-1	HIV-1	NNP
cord-264884-ydkigome	465	13	have	have	VBP
cord-264884-ydkigome	465	14	shown	show	VBN
cord-264884-ydkigome	465	15	mixed	mixed	JJ
cord-264884-ydkigome	465	16	populations	population	NNS
cord-264884-ydkigome	465	17	and	and	CC
cord-264884-ydkigome	465	18	unusual	unusual	JJ
cord-264884-ydkigome	465	19	polymorphism	polymorphism	NN
cord-264884-ydkigome	465	20	in	in	IN
cord-264884-ydkigome	465	21	the	the	DT
cord-264884-ydkigome	465	22	early	early	JJ
cord-264884-ydkigome	465	23	phase	phase	NN
cord-264884-ydkigome	465	24	of	of	IN
cord-264884-ydkigome	465	25	HIV	HIV	NNP
cord-264884-ydkigome	465	26	infection	infection	NN
cord-264884-ydkigome	465	27	,	,	,
cord-264884-ydkigome	465	28	sometimes	sometimes	RB
cord-264884-ydkigome	465	29	contributing	contribute	VBG
cord-264884-ydkigome	465	30	to	to	IN
cord-264884-ydkigome	465	31	long	long	JJ
cord-264884-ydkigome	465	32	-	-	HYPH
cord-264884-ydkigome	465	33	term	term	NN
cord-264884-ydkigome	465	34	non	non	JJ
cord-264884-ydkigome	465	35	-	-	JJ
cord-264884-ydkigome	465	36	progression	progression	JJ
cord-264884-ydkigome	465	37	(	(	-LRB-
cord-264884-ydkigome	465	38	LTNP	LTNP	NNP
cord-264884-ydkigome	465	39	)	)	-RRB-
cord-264884-ydkigome	465	40	(	(	-LRB-
cord-264884-ydkigome	465	41	Alexander	Alexander	NNP
cord-264884-ydkigome	465	42	et	et	NNP
cord-264884-ydkigome	465	43	al	al	NNP
cord-264884-ydkigome	465	44	.	.	NNP
cord-264884-ydkigome	465	45	,	,	,
cord-264884-ydkigome	465	46	2000	2000	CD
cord-264884-ydkigome	465	47	)	)	-RRB-
cord-264884-ydkigome	465	48	.	.	.
cord-264884-ydkigome	466	1	One	one	CD
cord-264884-ydkigome	466	2	population	population	NN
cord-264884-ydkigome	466	3	of	of	IN
cord-264884-ydkigome	466	4	LTNPs	ltnp	NNS
cord-264884-ydkigome	466	5	was	be	VBD
cord-264884-ydkigome	466	6	reported	report	VBN
cord-264884-ydkigome	466	7	to	to	TO
cord-264884-ydkigome	466	8	have	have	VB
cord-264884-ydkigome	466	9	been	be	VBN
cord-264884-ydkigome	466	10	colonized	colonize	VBN
cord-264884-ydkigome	466	11	by	by	IN
cord-264884-ydkigome	466	12	an	an	DT
cord-264884-ydkigome	466	13	HIV	HIV	NNP
cord-264884-ydkigome	466	14	variant	variant	NN
cord-264884-ydkigome	466	15	that	that	WDT
cord-264884-ydkigome	466	16	showed	show	VBD
cord-264884-ydkigome	466	17	low	low	JJ
cord-264884-ydkigome	466	18	virus	virus	NN
cord-264884-ydkigome	466	19	replication	replication	NN
cord-264884-ydkigome	466	20	and	and	CC
cord-264884-ydkigome	466	21	slow	slow	JJ
cord-264884-ydkigome	466	22	or	or	CC
cord-264884-ydkigome	466	23	arrested	arrest	VBN
cord-264884-ydkigome	466	24	evolution	evolution	NN
cord-264884-ydkigome	466	25	(	(	-LRB-
cord-264884-ydkigome	466	26	Bello	Bello	NNP
cord-264884-ydkigome	466	27	et	et	FW
cord-264884-ydkigome	466	28	al	al	NNP
cord-264884-ydkigome	466	29	.	.	NNP
cord-264884-ydkigome	466	30	,	,	,
cord-264884-ydkigome	466	31	2005	2005	CD
cord-264884-ydkigome	466	32	)	)	-RRB-
cord-264884-ydkigome	466	33	.	.	.
cord-264884-ydkigome	467	1	In	in	IN
cord-264884-ydkigome	467	2	another	another	DT
cord-264884-ydkigome	467	3	case	case	NN
cord-264884-ydkigome	467	4	,	,	,
cord-264884-ydkigome	467	5	a	a	DT
cord-264884-ydkigome	467	6	stable	stable	JJ
cord-264884-ydkigome	467	7	non	non	AFX
cord-264884-ydkigome	467	8	-	-	JJ
cord-264884-ydkigome	467	9	progressor	progressor	NN
cord-264884-ydkigome	467	10	was	be	VBD
cord-264884-ydkigome	467	11	colonized	colonize	VBN
cord-264884-ydkigome	467	12	by	by	IN
cord-264884-ydkigome	467	13	a	a	DT
cord-264884-ydkigome	467	14	replication	replication	NN
cord-264884-ydkigome	467	15	incompetent	incompetent	JJ
cord-264884-ydkigome	467	16	version	version	NN
cord-264884-ydkigome	467	17	of	of	IN
cord-264884-ydkigome	467	18	HIV-1	HIV-1	NNP
cord-264884-ydkigome	468	1	(	(	-LRB-
cord-264884-ydkigome	468	2	Wang	Wang	NNP
cord-264884-ydkigome	468	3	et	et	NNP
cord-264884-ydkigome	468	4	al	al	NNP
cord-264884-ydkigome	468	5	.	.	NNP
cord-264884-ydkigome	468	6	,	,	,
cord-264884-ydkigome	468	7	2003	2003	CD
cord-264884-ydkigome	468	8	)	)	-RRB-
cord-264884-ydkigome	468	9	.	.	.
cord-264884-ydkigome	469	1	Some	some	DT
cord-264884-ydkigome	469	2	of	of	IN
cord-264884-ydkigome	469	3	these	these	DT
cord-264884-ydkigome	469	4	non	non	NNS
cord-264884-ydkigome	469	5	-	-	NNS
cord-264884-ydkigome	469	6	progressors	progressor	NNS
cord-264884-ydkigome	469	7	also	also	RB
cord-264884-ydkigome	469	8	appear	appear	VBP
cord-264884-ydkigome	469	9	to	to	TO
cord-264884-ydkigome	469	10	resist	resist	VB
cord-264884-ydkigome	469	11	super	super	NN
cord-264884-ydkigome	469	12	-	-	NN
cord-264884-ydkigome	469	13	infection	infection	NN
cord-264884-ydkigome	469	14	.	.	.
cord-264884-ydkigome	470	1	It	-PRON-	PRP
cord-264884-ydkigome	470	2	seems	seem	VBZ
cord-264884-ydkigome	470	3	clear	clear	JJ
cord-264884-ydkigome	470	4	that	that	IN
cord-264884-ydkigome	470	5	at	at	IN
cord-264884-ydkigome	470	6	least	least	JJS
cord-264884-ydkigome	470	7	in	in	IN
cord-264884-ydkigome	470	8	these	these	DT
cord-264884-ydkigome	470	9	exceptional	exceptional	JJ
cord-264884-ydkigome	470	10	situations	situation	NNS
cord-264884-ydkigome	470	11	,	,	,
cord-264884-ydkigome	470	12	non	non	JJ
cord-264884-ydkigome	470	13	-	-	JJ
cord-264884-ydkigome	470	14	majority	majority	JJ
cord-264884-ydkigome	470	15	HIVs	hiv	NNS
cord-264884-ydkigome	470	16	are	be	VBP
cord-264884-ydkigome	470	17	crucial	crucial	JJ
cord-264884-ydkigome	470	18	to	to	IN
cord-264884-ydkigome	470	19	the	the	DT
cord-264884-ydkigome	470	20	outcome	outcome	NN
cord-264884-ydkigome	470	21	.	.	.
cord-264884-ydkigome	471	1	There	there	EX
cord-264884-ydkigome	471	2	is	be	VBZ
cord-264884-ydkigome	471	3	also	also	RB
cord-264884-ydkigome	471	4	reason	reason	NN
cord-264884-ydkigome	471	5	to	to	TO
cord-264884-ydkigome	471	6	think	think	VB
cord-264884-ydkigome	471	7	that	that	IN
cord-264884-ydkigome	471	8	other	other	JJ
cord-264884-ydkigome	471	9	retroviruses	retrovirus	NNS
cord-264884-ydkigome	471	10	have	have	VBP
cord-264884-ydkigome	471	11	had	have	VBN
cord-264884-ydkigome	471	12	a	a	DT
cord-264884-ydkigome	471	13	major	major	JJ
cord-264884-ydkigome	471	14	infl	infl	NN
cord-264884-ydkigome	471	15	uence	uence	NN
cord-264884-ydkigome	471	16	on	on	IN
cord-264884-ydkigome	471	17	recent	recent	JJ
cord-264884-ydkigome	471	18	primate	primate	JJ
cord-264884-ydkigome	471	19	and	and	CC
cord-264884-ydkigome	471	20	human	human	JJ
cord-264884-ydkigome	471	21	evolution	evolution	NN
cord-264884-ydkigome	471	22	,	,	,
cord-264884-ydkigome	471	23	such	such	JJ
cord-264884-ydkigome	471	24	as	as	IN
cord-264884-ydkigome	471	25	apathogenic	apathogenic	NNP
cord-264884-ydkigome	471	26	persisting	persist	VBG
cord-264884-ydkigome	471	27	foamy	foamy	JJ
cord-264884-ydkigome	471	28	virus	virus	NN
cord-264884-ydkigome	471	29	in	in	IN
cord-264884-ydkigome	471	30	primates	primate	NNS
cord-264884-ydkigome	471	31	(	(	-LRB-
cord-264884-ydkigome	471	32	Switzer	Switzer	NNP
cord-264884-ydkigome	471	33	et	et	NNP
cord-264884-ydkigome	471	34	al	al	NNP
cord-264884-ydkigome	471	35	.	.	NNP
cord-264884-ydkigome	471	36	,	,	,
cord-264884-ydkigome	471	37	2005	2005	CD
cord-264884-ydkigome	471	38	;	;	:
cord-264884-ydkigome	471	39	Murray	Murray	NNP
cord-264884-ydkigome	471	40	and	and	CC
cord-264884-ydkigome	471	41	Linial	Linial	NNP
cord-264884-ydkigome	471	42	,	,	,
cord-264884-ydkigome	471	43	2006	2006	CD
cord-264884-ydkigome	471	44	)	)	-RRB-
cord-264884-ydkigome	471	45	.	.	.
cord-264884-ydkigome	472	1	Human	human	JJ
cord-264884-ydkigome	472	2	antiretroviral	antiretroviral	JJ
cord-264884-ydkigome	472	3	genes	gene	NNS
cord-264884-ydkigome	472	4	seem	seem	VBP
cord-264884-ydkigome	472	5	to	to	TO
cord-264884-ydkigome	472	6	have	have	VB
cord-264884-ydkigome	472	7	undergone	undergo	VBN
cord-264884-ydkigome	472	8	recent	recent	JJ
cord-264884-ydkigome	472	9	adaptations	adaptation	NNS
cord-264884-ydkigome	472	10	,	,	,
cord-264884-ydkigome	472	11	such	such	JJ
cord-264884-ydkigome	472	12	as	as	IN
cord-264884-ydkigome	472	13	APOBEC3	APOBEC3	NNP
cord-264884-ydkigome	472	14	,	,	,
cord-264884-ydkigome	472	15	which	which	WDT
cord-264884-ydkigome	472	16	can	can	MD
cord-264884-ydkigome	472	17	interfere	interfere	VB
cord-264884-ydkigome	472	18	with	with	IN
cord-264884-ydkigome	472	19	exogenous	exogenous	JJ
cord-264884-ydkigome	472	20	retroviruses	retrovirus	NNS
cord-264884-ydkigome	472	21	(	(	-LRB-
cord-264884-ydkigome	472	22	such	such	JJ
cord-264884-ydkigome	472	23	as	as	IN
cord-264884-ydkigome	472	24	MLV	MLV	NNP
cord-264884-ydkigome	472	25	and	and	CC
cord-264884-ydkigome	472	26	SIV	SIV	NNP
cord-264884-ydkigome	472	27	)	)	-RRB-
cord-264884-ydkigome	472	28	and	and	CC
cord-264884-ydkigome	472	29	underwent	undergo	VBD
cord-264884-ydkigome	472	30	an	an	DT
cord-264884-ydkigome	472	31	expansion	expansion	NN
cord-264884-ydkigome	472	32	in	in	IN
cord-264884-ydkigome	472	33	the	the	DT
cord-264884-ydkigome	472	34	hominid	hominid	JJ
cord-264884-ydkigome	472	35	lineage	lineage	NN
cord-264884-ydkigome	472	36	(	(	-LRB-
cord-264884-ydkigome	472	37	Esnault	Esnault	NNP
cord-264884-ydkigome	472	38	et	et	FW
cord-264884-ydkigome	472	39	al	al	NNP
cord-264884-ydkigome	472	40	.	.	NNP
cord-264884-ydkigome	472	41	,	,	,
cord-264884-ydkigome	472	42	2005	2005	CD
cord-264884-ydkigome	472	43	)	)	-RRB-
cord-264884-ydkigome	472	44	.	.	.
cord-264884-ydkigome	473	1	It	-PRON-	PRP
cord-264884-ydkigome	473	2	thus	thus	RB
cord-264884-ydkigome	473	3	seems	seem	VBZ
cord-264884-ydkigome	473	4	clear	clear	JJ
cord-264884-ydkigome	473	5	that	that	IN
cord-264884-ydkigome	473	6	human	human	JJ
cord-264884-ydkigome	473	7	and	and	CC
cord-264884-ydkigome	473	8	primate	primate	JJ
cord-264884-ydkigome	473	9	evolution	evolution	NN
cord-264884-ydkigome	473	10	has	have	VBZ
cord-264884-ydkigome	473	11	been	be	VBN
cord-264884-ydkigome	473	12	signifi	signifi	NNP
cord-264884-ydkigome	473	13	cantly	cantly	RB
cord-264884-ydkigome	473	14	affected	affect	VBN
cord-264884-ydkigome	473	15	by	by	IN
cord-264884-ydkigome	473	16	earlier	early	RBR
cord-264884-ydkigome	473	17	,	,	,
cord-264884-ydkigome	473	18	prevalent	prevalent	JJ
cord-264884-ydkigome	473	19	primate	primate	NN
cord-264884-ydkigome	473	20	retroviruses	retrovirus	NNS
cord-264884-ydkigome	473	21	.	.	.
cord-264884-ydkigome	474	1	Another	another	DT
cord-264884-ydkigome	474	2	important	important	JJ
cord-264884-ydkigome	474	3	human	human	JJ
cord-264884-ydkigome	474	4	-	-	HYPH
cord-264884-ydkigome	474	5	virus	virus	NN
cord-264884-ydkigome	474	6	quasispecies	quasispecie	NNS
cord-264884-ydkigome	474	7	story	story	NN
cord-264884-ydkigome	474	8	that	that	WDT
cord-264884-ydkigome	474	9	has	have	VBZ
cord-264884-ydkigome	474	10	long	long	RB
cord-264884-ydkigome	474	11	been	be	VBN
cord-264884-ydkigome	474	12	recognized	recognize	VBN
cord-264884-ydkigome	474	13	is	be	VBZ
cord-264884-ydkigome	474	14	with	with	IN
cord-264884-ydkigome	474	15	hepatitis	hepatitis	NNP
cord-264884-ydkigome	474	16	C	C	NNP
cord-264884-ydkigome	474	17	virus	virus	NN
cord-264884-ydkigome	474	18	(	(	-LRB-
cord-264884-ydkigome	474	19	HCV	HCV	NNP
cord-264884-ydkigome	474	20	)	)	-RRB-
cord-264884-ydkigome	474	21	,	,	,
cord-264884-ydkigome	474	22	(	(	-LRB-
cord-264884-ydkigome	474	23	see	see	VB
cord-264884-ydkigome	474	24	Chapter	chapter	NN
cord-264884-ydkigome	474	25	15	15	CD
cord-264884-ydkigome	474	26	;	;	:
cord-264884-ydkigome	474	27	Domingo	Domingo	NNP
cord-264884-ydkigome	474	28	and	and	CC
cord-264884-ydkigome	474	29	Gomez	Gomez	NNP
cord-264884-ydkigome	474	30	,	,	,
cord-264884-ydkigome	474	31	2007	2007	CD
cord-264884-ydkigome	474	32	)	)	-RRB-
cord-264884-ydkigome	474	33	.	.	.
cord-264884-ydkigome	475	1	HCV	HCV	NNP
cord-264884-ydkigome	475	2	seems	seem	VBZ
cord-264884-ydkigome	475	3	to	to	TO
cord-264884-ydkigome	475	4	have	have	VB
cord-264884-ydkigome	475	5	adapted	adapt	VBN
cord-264884-ydkigome	475	6	to	to	IN
cord-264884-ydkigome	475	7	humans	human	NNS
cord-264884-ydkigome	475	8	in	in	IN
cord-264884-ydkigome	475	9	the	the	DT
cord-264884-ydkigome	475	10	recent	recent	JJ
cord-264884-ydkigome	475	11	past	past	NN
cord-264884-ydkigome	475	12	,	,	,
cord-264884-ydkigome	475	13	possibly	possibly	RB
cord-264884-ydkigome	475	14	from	from	IN
cord-264884-ydkigome	475	15	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	475	16	enteric	enteric	JJ
cord-264884-ydkigome	475	17	primate	primate	NN
cord-264884-ydkigome	475	18	viruses	virus	NNS
cord-264884-ydkigome	475	19	currently	currently	RB
cord-264884-ydkigome	475	20	found	find	VBN
cord-264884-ydkigome	475	21	in	in	IN
cord-264884-ydkigome	475	22	Africa	Africa	NNP
cord-264884-ydkigome	475	23	(	(	-LRB-
cord-264884-ydkigome	475	24	Smith	Smith	NNP
cord-264884-ydkigome	475	25	et	et	NNP
cord-264884-ydkigome	475	26	al	al	NNP
cord-264884-ydkigome	475	27	.	.	NNP
cord-264884-ydkigome	475	28	,	,	,
cord-264884-ydkigome	475	29	1997	1997	CD
cord-264884-ydkigome	475	30	)	)	-RRB-
cord-264884-ydkigome	475	31	.	.	.
cord-264884-ydkigome	476	1	As	as	IN
cord-264884-ydkigome	476	2	HCV	HCV	NNP
cord-264884-ydkigome	476	3	remains	remain	VBZ
cord-264884-ydkigome	476	4	an	an	DT
cord-264884-ydkigome	476	5	infection	infection	NN
cord-264884-ydkigome	476	6	predominantly	predominantly	RB
cord-264884-ydkigome	476	7	transmitted	transmit	VBN
cord-264884-ydkigome	476	8	by	by	IN
cord-264884-ydkigome	476	9	blood	blood	NN
cord-264884-ydkigome	476	10	,	,	,
cord-264884-ydkigome	476	11	it	-PRON-	PRP
cord-264884-ydkigome	476	12	does	do	VBZ
cord-264884-ydkigome	476	13	not	not	RB
cord-264884-ydkigome	476	14	appear	appear	VB
cord-264884-ydkigome	476	15	to	to	TO
cord-264884-ydkigome	476	16	have	have	VB
cord-264884-ydkigome	476	17	fully	fully	RB
cord-264884-ydkigome	476	18	adapted	adapt	VBN
cord-264884-ydkigome	476	19	to	to	IN
cord-264884-ydkigome	476	20	the	the	DT
cord-264884-ydkigome	476	21	tissues	tissue	NNS
cord-264884-ydkigome	476	22	of	of	IN
cord-264884-ydkigome	476	23	and	and	CC
cord-264884-ydkigome	476	24	transmission	transmission	NN
cord-264884-ydkigome	476	25	within	within	IN
cord-264884-ydkigome	476	26	its	-PRON-	PRP$
cord-264884-ydkigome	476	27	human	human	JJ
cord-264884-ydkigome	476	28	host	host	NN
cord-264884-ydkigome	476	29	.	.	.
cord-264884-ydkigome	477	1	However	however	RB
cord-264884-ydkigome	477	2	,	,	,
cord-264884-ydkigome	477	3	like	like	IN
cord-264884-ydkigome	477	4	HIV-1	HIV-1	NNP
cord-264884-ydkigome	477	5	,	,	,
cord-264884-ydkigome	477	6	HCV	HCV	NNP
cord-264884-ydkigome	477	7	has	have	VBZ
cord-264884-ydkigome	477	8	long	long	RB
cord-264884-ydkigome	477	9	been	be	VBN
cord-264884-ydkigome	477	10	recognized	recognize	VBN
cord-264884-ydkigome	477	11	to	to	TO
cord-264884-ydkigome	477	12	generate	generate	VB
cord-264884-ydkigome	477	13	quasispecies	quasispecie	NNS
cord-264884-ydkigome	477	14	in	in	IN
cord-264884-ydkigome	477	15	chronically	chronically	RB
cord-264884-ydkigome	477	16	infected	infected	JJ
cord-264884-ydkigome	477	17	people	people	NNS
cord-264884-ydkigome	477	18	(	(	-LRB-
cord-264884-ydkigome	477	19	Martell	Martell	NNP
cord-264884-ydkigome	477	20	et	et	NNP
cord-264884-ydkigome	477	21	al	al	NNP
cord-264884-ydkigome	477	22	.	.	NNP
cord-264884-ydkigome	477	23	,	,	,
cord-264884-ydkigome	477	24	1992	1992	CD
cord-264884-ydkigome	477	25	)	)	-RRB-
cord-264884-ydkigome	477	26	and	and	CC
cord-264884-ydkigome	477	27	it	-PRON-	PRP
cord-264884-ydkigome	477	28	soon	soon	RB
cord-264884-ydkigome	477	29	became	become	VBD
cord-264884-ydkigome	477	30	apparent	apparent	JJ
cord-264884-ydkigome	477	31	that	that	IN
cord-264884-ydkigome	477	32	the	the	DT
cord-264884-ydkigome	477	33	viral	viral	JJ
cord-264884-ydkigome	477	34	quasispecies	quasispecie	NNS
cord-264884-ydkigome	477	35	are	be	VBP
cord-264884-ydkigome	477	36	affected	affect	VBN
cord-264884-ydkigome	477	37	by	by	IN
cord-264884-ydkigome	477	38	and	and	CC
cord-264884-ydkigome	477	39	affects	affect	VBZ
cord-264884-ydkigome	477	40	the	the	DT
cord-264884-ydkigome	477	41	outcome	outcome	NN
cord-264884-ydkigome	477	42	of	of	IN
cord-264884-ydkigome	477	43	antiviral	antiviral	JJ
cord-264884-ydkigome	477	44	therapy	therapy	NN
cord-264884-ydkigome	477	45	Hohne	Hohne	NNP
cord-264884-ydkigome	477	46	et	et	NNP
cord-264884-ydkigome	477	47	al	al	NNP
cord-264884-ydkigome	477	48	.	.	NNP
cord-264884-ydkigome	477	49	,	,	,
cord-264884-ydkigome	477	50	1994	1994	CD
cord-264884-ydkigome	477	51	;	;	:
cord-264884-ydkigome	477	52	Kurosaki	Kurosaki	NNP
cord-264884-ydkigome	477	53	et	et	NNP
cord-264884-ydkigome	477	54	al	al	NNP
cord-264884-ydkigome	477	55	.	.	NNP
cord-264884-ydkigome	477	56	,	,	,
cord-264884-ydkigome	477	57	1994	1994	CD
cord-264884-ydkigome	477	58	;	;	.
cord-264884-ydkigome	478	1	Okamoto	Okamoto	NNP
cord-264884-ydkigome	478	2	and	and	CC
cord-264884-ydkigome	478	3	Mishiro	Mishiro	NNP
cord-264884-ydkigome	478	4	,	,	,
cord-264884-ydkigome	478	5	1994	1994	CD
cord-264884-ydkigome	478	6	)	)	-RRB-
cord-264884-ydkigome	478	7	.	.	.
cord-264884-ydkigome	479	1	Thus	thus	RB
cord-264884-ydkigome	479	2	,	,	,
cord-264884-ydkigome	479	3	successful	successful	JJ
cord-264884-ydkigome	479	4	antiviral	antiviral	JJ
cord-264884-ydkigome	479	5	therapy	therapy	NN
cord-264884-ydkigome	479	6	is	be	VBZ
cord-264884-ydkigome	479	7	directly	directly	RB
cord-264884-ydkigome	479	8	correlated	correlate	VBN
cord-264884-ydkigome	479	9	with	with	IN
cord-264884-ydkigome	479	10	an	an	DT
cord-264884-ydkigome	479	11	initial	initial	JJ
cord-264884-ydkigome	479	12	dramatic	dramatic	JJ
cord-264884-ydkigome	479	13	reduction	reduction	NN
cord-264884-ydkigome	479	14	in	in	IN
cord-264884-ydkigome	479	15	genetic	genetic	JJ
cord-264884-ydkigome	479	16	diversity	diversity	NN
cord-264884-ydkigome	479	17	.	.	.
cord-264884-ydkigome	480	1	Unfortunately	unfortunately	RB
cord-264884-ydkigome	480	2	,	,	,
cord-264884-ydkigome	480	3	it	-PRON-	PRP
cord-264884-ydkigome	480	4	has	have	VBZ
cord-264884-ydkigome	480	5	become	become	VBN
cord-264884-ydkigome	480	6	clear	clear	JJ
cord-264884-ydkigome	480	7	that	that	IN
cord-264884-ydkigome	480	8	only	only	RB
cord-264884-ydkigome	480	9	a	a	DT
cord-264884-ydkigome	480	10	minority	minority	NN
cord-264884-ydkigome	480	11	of	of	IN
cord-264884-ydkigome	480	12	HCV	HCV	NNP
cord-264884-ydkigome	480	13	-	-	HYPH
cord-264884-ydkigome	480	14	infected	infect	VBN
cord-264884-ydkigome	480	15	individuals	individual	NNS
cord-264884-ydkigome	480	16	will	will	MD
cord-264884-ydkigome	480	17	respond	respond	VB
cord-264884-ydkigome	480	18	favorably	favorably	RB
cord-264884-ydkigome	480	19	to	to	IN
cord-264884-ydkigome	480	20	a	a	DT
cord-264884-ydkigome	480	21	combination	combination	NN
cord-264884-ydkigome	480	22	of	of	IN
cord-264884-ydkigome	480	23	interferon	interferon	NN
cord-264884-ydkigome	480	24	and	and	CC
cord-264884-ydkigome	480	25	ribivarin	ribivarin	NNP
cord-264884-ydkigome	480	26	.	.	.
cord-264884-ydkigome	481	1	Thus	thus	RB
cord-264884-ydkigome	481	2	it	-PRON-	PRP
cord-264884-ydkigome	481	3	seems	seem	VBZ
cord-264884-ydkigome	481	4	to	to	TO
cord-264884-ydkigome	481	5	be	be	VB
cord-264884-ydkigome	481	6	diversity	diversity	NN
cord-264884-ydkigome	481	7	per	per	FW
cord-264884-ydkigome	481	8	se	se	FW
cord-264884-ydkigome	481	9	and	and	CC
cord-264884-ydkigome	481	10	the	the	DT
cord-264884-ydkigome	481	11	resulting	result	VBG
cord-264884-ydkigome	481	12	structure	structure	NN
cord-264884-ydkigome	481	13	of	of	IN
cord-264884-ydkigome	481	14	an	an	DT
cord-264884-ydkigome	481	15	HCV	HCV	NNP
cord-264884-ydkigome	481	16	quasispecies	quasispecie	NNS
cord-264884-ydkigome	481	17	that	that	WDT
cord-264884-ydkigome	481	18	has	have	VBZ
cord-264884-ydkigome	481	19	a	a	DT
cord-264884-ydkigome	481	20	direct	direct	JJ
cord-264884-ydkigome	481	21	consequence	consequence	NN
cord-264884-ydkigome	481	22	to	to	IN
cord-264884-ydkigome	481	23	human	human	JJ
cord-264884-ydkigome	481	24	health	health	NN
cord-264884-ydkigome	481	25	.	.	.
cord-264884-ydkigome	482	1	However	however	RB
cord-264884-ydkigome	482	2	,	,	,
cord-264884-ydkigome	482	3	since	since	IN
cord-264884-ydkigome	482	4	HCV	HCV	NNP
cord-264884-ydkigome	482	5	is	be	VBZ
cord-264884-ydkigome	482	6	less	less	RBR
cord-264884-ydkigome	482	7	well	well	RB
cord-264884-ydkigome	482	8	-	-	HYPH
cord-264884-ydkigome	482	9	adapted	adapt	VBN
cord-264884-ydkigome	482	10	to	to	IN
cord-264884-ydkigome	482	11	humans	human	NNS
cord-264884-ydkigome	482	12	compared	compare	VBN
cord-264884-ydkigome	482	13	with	with	IN
cord-264884-ydkigome	482	14	HIV-1	HIV-1	NNP
cord-264884-ydkigome	482	15	,	,	,
cord-264884-ydkigome	482	16	it	-PRON-	PRP
cord-264884-ydkigome	482	17	does	do	VBZ
cord-264884-ydkigome	482	18	not	not	RB
cord-264884-ydkigome	482	19	pose	pose	VB
cord-264884-ydkigome	482	20	the	the	DT
cord-264884-ydkigome	482	21	same	same	JJ
cord-264884-ydkigome	482	22	threat	threat	NN
cord-264884-ydkigome	482	23	to	to	TO
cord-264884-ydkigome	482	24	potentially	potentially	RB
cord-264884-ydkigome	482	25	provoke	provoke	VB
cord-264884-ydkigome	482	26	an	an	DT
cord-264884-ydkigome	482	27	evolutionary	evolutionary	JJ
cord-264884-ydkigome	482	28	event	event	NN
cord-264884-ydkigome	482	29	in	in	IN
cord-264884-ydkigome	482	30	human	human	JJ
cord-264884-ydkigome	482	31	evolution	evolution	NN
cord-264884-ydkigome	482	32	.	.	.
cord-264884-ydkigome	483	1	VSV	VSV	NNP
cord-264884-ydkigome	483	2	is	be	VBZ
cord-264884-ydkigome	483	3	a	a	DT
cord-264884-ydkigome	483	4	negative	negative	JJ
cord-264884-ydkigome	483	5	-	-	HYPH
cord-264884-ydkigome	483	6	stranded	strand	VBN
cord-264884-ydkigome	483	7	RNA	RNA	NNP
cord-264884-ydkigome	483	8	virus	virus	NN
cord-264884-ydkigome	483	9	that	that	WDT
cord-264884-ydkigome	483	10	has	have	VBZ
cord-264884-ydkigome	483	11	been	be	VBN
cord-264884-ydkigome	483	12	a	a	DT
cord-264884-ydkigome	483	13	very	very	RB
cord-264884-ydkigome	483	14	important	important	JJ
cord-264884-ydkigome	483	15	experimental	experimental	JJ
cord-264884-ydkigome	483	16	model	model	NN
cord-264884-ydkigome	483	17	and	and	CC
cord-264884-ydkigome	483	18	has	have	VBZ
cord-264884-ydkigome	483	19	provided	provide	VBN
cord-264884-ydkigome	483	20	many	many	JJ
cord-264884-ydkigome	483	21	laboratory	laboratory	NN
cord-264884-ydkigome	483	22	measurements	measurement	NNS
cord-264884-ydkigome	483	23	regarding	regard	VBG
cord-264884-ydkigome	483	24	quasispecies	quasispecie	NNS
cord-264884-ydkigome	483	25	theory	theory	NN
cord-264884-ydkigome	483	26	(	(	-LRB-
cord-264884-ydkigome	483	27	see	see	VB
cord-264884-ydkigome	483	28	Chapter	chapter	NN
cord-264884-ydkigome	483	29	4	4	CD
cord-264884-ydkigome	483	30	)	)	-RRB-
cord-264884-ydkigome	483	31	.	.	.
cord-264884-ydkigome	484	1	Using	use	VBG
cord-264884-ydkigome	484	2	VSV	VSV	NNP
cord-264884-ydkigome	484	3	,	,	,
cord-264884-ydkigome	484	4	evidence	evidence	NN
cord-264884-ydkigome	484	5	supporting	support	VBG
cord-264884-ydkigome	484	6	the	the	DT
cord-264884-ydkigome	484	7	Red	Red	NNP
cord-264884-ydkigome	484	8	Queen	Queen	NNP
cord-264884-ydkigome	484	9	hypothesis	hypothesis	NN
cord-264884-ydkigome	484	10	,	,	,
cord-264884-ydkigome	484	11	involving	involve	VBG
cord-264884-ydkigome	484	12	unending	unending	JJ
cord-264884-ydkigome	484	13	adaptation	adaptation	NN
cord-264884-ydkigome	484	14	to	to	IN
cord-264884-ydkigome	484	15	greater	great	JJR
cord-264884-ydkigome	484	16	competition	competition	NN
cord-264884-ydkigome	484	17	and	and	CC
cord-264884-ydkigome	484	18	Mueller	Mueller	NNP
cord-264884-ydkigome	484	19	'	'	POS
cord-264884-ydkigome	484	20	s	s	POS
cord-264884-ydkigome	484	21	ratchet	ratchet	NN
cord-264884-ydkigome	484	22	has	have	VBZ
cord-264884-ydkigome	484	23	been	be	VBN
cord-264884-ydkigome	484	24	presented	present	VBN
cord-264884-ydkigome	484	25	(	(	-LRB-
cord-264884-ydkigome	484	26	Clarke	Clarke	NNP
cord-264884-ydkigome	484	27	et	et	NNP
cord-264884-ydkigome	484	28	al	al	NNP
cord-264884-ydkigome	484	29	.	.	.
cord-264884-ydkigome	485	1	,	,	,
cord-264884-ydkigome	485	2	1994	1994	CD
cord-264884-ydkigome	485	3	;	;	:
cord-264884-ydkigome	485	4	Novella	Novella	NNP
cord-264884-ydkigome	485	5	et	et	FW
cord-264884-ydkigome	485	6	al	al	NNP
cord-264884-ydkigome	485	7	.	.	NNP
cord-264884-ydkigome	485	8	,	,	,
cord-264884-ydkigome	485	9	1995	1995	CD
cord-264884-ydkigome	485	10	;	;	:
cord-264884-ydkigome	485	11	Elena	Elena	NNP
cord-264884-ydkigome	485	12	et	et	NNP
cord-264884-ydkigome	485	13	al	al	NNP
cord-264884-ydkigome	485	14	.	.	NNP
cord-264884-ydkigome	485	15	,	,	,
cord-264884-ydkigome	485	16	1996	1996	CD
cord-264884-ydkigome	485	17	)	)	-RRB-
cord-264884-ydkigome	485	18	.	.	.
cord-264884-ydkigome	486	1	When	when	WRB
cord-264884-ydkigome	486	2	VSV	VSV	NNP
cord-264884-ydkigome	486	3	was	be	VBD
cord-264884-ydkigome	486	4	evaluated	evaluate	VBN
cord-264884-ydkigome	486	5	as	as	IN
cord-264884-ydkigome	486	6	an	an	DT
cord-264884-ydkigome	486	7	arbovirus	arbovirus	NN
cord-264884-ydkigome	486	8	,	,	,
cord-264884-ydkigome	486	9	requiring	require	VBG
cord-264884-ydkigome	486	10	adaptation	adaptation	NN
cord-264884-ydkigome	486	11	to	to	IN
cord-264884-ydkigome	486	12	alternating	alternate	VBG
cord-264884-ydkigome	486	13	and	and	CC
cord-264884-ydkigome	486	14	opposing	oppose	VBG
cord-264884-ydkigome	486	15	fi	fi	NN
cord-264884-ydkigome	486	16	tness	tness	NN
cord-264884-ydkigome	486	17	of	of	IN
cord-264884-ydkigome	486	18	insect	insect	NN
cord-264884-ydkigome	486	19	and	and	CC
cord-264884-ydkigome	486	20	mammalian	mammalian	JJ
cord-264884-ydkigome	486	21	host	host	NN
cord-264884-ydkigome	486	22	,	,	,
cord-264884-ydkigome	486	23	it	-PRON-	PRP
cord-264884-ydkigome	486	24	was	be	VBD
cord-264884-ydkigome	486	25	also	also	RB
cord-264884-ydkigome	486	26	apparent	apparent	JJ
cord-264884-ydkigome	486	27	that	that	IN
cord-264884-ydkigome	486	28	minority	minority	NN
cord-264884-ydkigome	486	29	quasispecies	quasispecie	NNS
cord-264884-ydkigome	486	30	populations	population	NNS
cord-264884-ydkigome	486	31	were	be	VBD
cord-264884-ydkigome	486	32	responsible	responsible	JJ
cord-264884-ydkigome	486	33	for	for	IN
cord-264884-ydkigome	486	34	maintaining	maintain	VBG
cord-264884-ydkigome	486	35	the	the	DT
cord-264884-ydkigome	486	36	apparently	apparently	RB
cord-264884-ydkigome	486	37	antagonistic	antagonistic	JJ
cord-264884-ydkigome	486	38	phenotypes	phenotype	NNS
cord-264884-ydkigome	486	39	(	(	-LRB-
cord-264884-ydkigome	486	40	Novella	novella	NN
cord-264884-ydkigome	486	41	et	et	FW
cord-264884-ydkigome	486	42	al	al	NNP
cord-264884-ydkigome	486	43	.	.	NNP
cord-264884-ydkigome	486	44	,	,	,
cord-264884-ydkigome	486	45	1999	1999	CD
cord-264884-ydkigome	486	46	)	)	-RRB-
cord-264884-ydkigome	486	47	.	.	.
cord-264884-ydkigome	487	1	Thus	thus	RB
cord-264884-ydkigome	487	2	here	here	RB
cord-264884-ydkigome	487	3	too	too	RB
cord-264884-ydkigome	487	4	,	,	,
cord-264884-ydkigome	487	5	the	the	DT
cord-264884-ydkigome	487	6	consortia	consortia	NN
cord-264884-ydkigome	487	7	character	character	NN
cord-264884-ydkigome	487	8	of	of	IN
cord-264884-ydkigome	487	9	a	a	DT
cord-264884-ydkigome	487	10	quasispecies	quasispecie	NNS
cord-264884-ydkigome	487	11	is	be	VBZ
cord-264884-ydkigome	487	12	clear	clear	JJ
cord-264884-ydkigome	487	13	.	.	.
cord-264884-ydkigome	488	1	Yet	yet	CC
cord-264884-ydkigome	488	2	in	in	IN
cord-264884-ydkigome	488	3	natural	natural	JJ
cord-264884-ydkigome	488	4	settings	setting	NNS
cord-264884-ydkigome	488	5	several	several	JJ
cord-264884-ydkigome	488	6	very	very	RB
cord-264884-ydkigome	488	7	different	different	JJ
cord-264884-ydkigome	488	8	virus	virus	NN
cord-264884-ydkigome	488	9	-	-	HYPH
cord-264884-ydkigome	488	10	host	host	NN
cord-264884-ydkigome	488	11	relationships	relationship	NNS
cord-264884-ydkigome	488	12	can	can	MD
cord-264884-ydkigome	488	13	be	be	VB
cord-264884-ydkigome	488	14	seen	see	VBN
cord-264884-ydkigome	488	15	with	with	IN
cord-264884-ydkigome	488	16	rhabdoviruses	rhabdovirus	NNS
cord-264884-ydkigome	488	17	.	.	.
cord-264884-ydkigome	489	1	A	a	DT
cord-264884-ydkigome	489	2	distant	distant	JJ
cord-264884-ydkigome	489	3	relative	relative	NN
cord-264884-ydkigome	489	4	of	of	IN
cord-264884-ydkigome	489	5	VSV	VSV	NNP
cord-264884-ydkigome	489	6	(	(	-LRB-
cord-264884-ydkigome	489	7	VHSV	VHSV	NNP
cord-264884-ydkigome	489	8	)	)	-RRB-
cord-264884-ydkigome	489	9	is	be	VBZ
cord-264884-ydkigome	489	10	also	also	RB
cord-264884-ydkigome	489	11	known	know	VBN
cord-264884-ydkigome	489	12	to	to	TO
cord-264884-ydkigome	489	13	be	be	VB
cord-264884-ydkigome	489	14	responsible	responsible	JJ
cord-264884-ydkigome	489	15	for	for	IN
cord-264884-ydkigome	489	16	mass	mass	JJ
cord-264884-ydkigome	489	17	die	die	NN
cord-264884-ydkigome	489	18	-	-	HYPH
cord-264884-ydkigome	489	19	off	off	NN
cord-264884-ydkigome	489	20	of	of	IN
cord-264884-ydkigome	489	21	commercially	commercially	RB
cord-264884-ydkigome	489	22	important	important	JJ
cord-264884-ydkigome	489	23	fi	fi	NN
cord-264884-ydkigome	489	24	sh	sh	XX
cord-264884-ydkigome	490	1	(	(	-LRB-
cord-264884-ydkigome	490	2	Marty	Marty	NNP
cord-264884-ydkigome	490	3	et	et	NNP
cord-264884-ydkigome	490	4	al	al	NNP
cord-264884-ydkigome	490	5	.	.	NNP
cord-264884-ydkigome	490	6	,	,	,
cord-264884-ydkigome	490	7	2003	2003	CD
cord-264884-ydkigome	490	8	)	)	-RRB-
cord-264884-ydkigome	490	9	.	.	.
cord-264884-ydkigome	491	1	This	this	DT
cord-264884-ydkigome	491	2	virus	virus	NN
cord-264884-ydkigome	491	3	infects	infect	VBZ
cord-264884-ydkigome	491	4	many	many	JJ
cord-264884-ydkigome	491	5	teleost	teleost	NN
cord-264884-ydkigome	491	6	species	specie	NNS
cord-264884-ydkigome	491	7	and	and	CC
cord-264884-ydkigome	491	8	has	have	VBZ
cord-264884-ydkigome	491	9	shown	show	VBN
cord-264884-ydkigome	491	10	100	100	CD
cord-264884-ydkigome	491	11	%	%	NN
cord-264884-ydkigome	491	12	mortality	mortality	NN
cord-264884-ydkigome	491	13	in	in	IN
cord-264884-ydkigome	491	14	many	many	JJ
cord-264884-ydkigome	491	15	experiments	experiment	NNS
cord-264884-ydkigome	491	16	(	(	-LRB-
cord-264884-ydkigome	491	17	i.e.	i.e.	FW
cord-264884-ydkigome	491	18	with	with	IN
cord-264884-ydkigome	491	19	i.p	i.p	NNP
cord-264884-ydkigome	491	20	.	.	NNP
cord-264884-ydkigome	491	21	inoculation	inoculation	NN
cord-264884-ydkigome	491	22	)	)	-RRB-
cord-264884-ydkigome	491	23	.	.	.
cord-264884-ydkigome	492	1	In	in	IN
cord-264884-ydkigome	492	2	natural	natural	JJ
cord-264884-ydkigome	492	3	outbreaks	outbreak	NNS
cord-264884-ydkigome	492	4	,	,	,
cord-264884-ydkigome	492	5	however	however	RB
cord-264884-ydkigome	492	6	,	,	,
cord-264884-ydkigome	492	7	it	-PRON-	PRP
cord-264884-ydkigome	492	8	has	have	VBZ
cord-264884-ydkigome	492	9	also	also	RB
cord-264884-ydkigome	492	10	shown	show	VBN
cord-264884-ydkigome	492	11	surprising	surprising	JJ
cord-264884-ydkigome	492	12	genetic	genetic	JJ
cord-264884-ydkigome	492	13	stability	stability	NN
cord-264884-ydkigome	493	1	(	(	-LRB-
cord-264884-ydkigome	493	2	Einer	Einer	NNP
cord-264884-ydkigome	493	3	-	-	HYPH
cord-264884-ydkigome	493	4	Jensen	Jensen	NNP
cord-264884-ydkigome	493	5	et	et	NNP
cord-264884-ydkigome	493	6	al	al	NNP
cord-264884-ydkigome	493	7	.	.	NNP
cord-264884-ydkigome	493	8	,	,	,
cord-264884-ydkigome	493	9	2006	2006	CD
cord-264884-ydkigome	493	10	)	)	-RRB-
cord-264884-ydkigome	493	11	.	.	.
cord-264884-ydkigome	494	1	Clearly	clearly	RB
cord-264884-ydkigome	494	2	error	error	NN
cord-264884-ydkigome	494	3	-	-	HYPH
cord-264884-ydkigome	494	4	prone	prone	JJ
cord-264884-ydkigome	494	5	rhabdovirus	rhabdovirus	NN
cord-264884-ydkigome	494	6	replication	replication	NN
cord-264884-ydkigome	494	7	must	must	MD
cord-264884-ydkigome	494	8	be	be	VB
cord-264884-ydkigome	494	9	kept	keep	VBN
cord-264884-ydkigome	494	10	in	in	IN
cord-264884-ydkigome	494	11	check	check	NN
cord-264884-ydkigome	494	12	by	by	IN
cord-264884-ydkigome	494	13	purifying	purify	VBG
cord-264884-ydkigome	494	14	selection	selection	NN
cord-264884-ydkigome	494	15	in	in	IN
cord-264884-ydkigome	494	16	this	this	DT
cord-264884-ydkigome	494	17	situation	situation	NN
cord-264884-ydkigome	494	18	.	.	.
cord-264884-ydkigome	495	1	In	in	IN
cord-264884-ydkigome	495	2	contrast	contrast	NN
cord-264884-ydkigome	495	3	,	,	,
cord-264884-ydkigome	495	4	another	another	DT
cord-264884-ydkigome	495	5	rhabdovirus	rhabdovirus	NNP
cord-264884-ydkigome	495	6	,	,	,
cord-264884-ydkigome	495	7	sigma	sigma	NNP
cord-264884-ydkigome	495	8	virus	virus	NN
cord-264884-ydkigome	495	9	of	of	IN
cord-264884-ydkigome	495	10	Drosophila	Drosophila	NNP
cord-264884-ydkigome	495	11	,	,	,
cord-264884-ydkigome	495	12	is	be	VBZ
cord-264884-ydkigome	495	13	associated	associate	VBN
cord-264884-ydkigome	495	14	with	with	IN
cord-264884-ydkigome	495	15	no	no	DT
cord-264884-ydkigome	495	16	mortality	mortality	NN
cord-264884-ydkigome	495	17	but	but	CC
cord-264884-ydkigome	495	18	is	be	VBZ
cord-264884-ydkigome	495	19	a	a	DT
cord-264884-ydkigome	495	20	vertically	vertically	RB
cord-264884-ydkigome	495	21	transmitted	transmit	VBN
cord-264884-ydkigome	495	22	persisting	persist	VBG
cord-264884-ydkigome	495	23	virus	virus	NN
cord-264884-ydkigome	495	24	in	in	IN
cord-264884-ydkigome	495	25	specifi	specifi	NN
cord-264884-ydkigome	495	26	c	c	NN
cord-264884-ydkigome	495	27	Drosophila	Drosophila	NNP
cord-264884-ydkigome	495	28	populations	population	NNS
cord-264884-ydkigome	495	29	(	(	-LRB-
cord-264884-ydkigome	495	30	Fleuriet	Fleuriet	NNP
cord-264884-ydkigome	495	31	,	,	,
cord-264884-ydkigome	495	32	1996	1996	CD
cord-264884-ydkigome	495	33	)	)	-RRB-
cord-264884-ydkigome	495	34	.	.	.
cord-264884-ydkigome	496	1	Yet	yet	CC
cord-264884-ydkigome	496	2	in	in	IN
cord-264884-ydkigome	496	3	some	some	DT
cord-264884-ydkigome	496	4	recent	recent	JJ
cord-264884-ydkigome	496	5	population	population	NN
cord-264884-ydkigome	496	6	measurements	measurement	NNS
cord-264884-ydkigome	496	7	,	,	,
cord-264884-ydkigome	496	8	sigma	sigma	NNP
cord-264884-ydkigome	496	9	virus	virus	NN
cord-264884-ydkigome	496	10	infected	infect	VBD
cord-264884-ydkigome	496	11	Drosophila	Drosophila	NNP
cord-264884-ydkigome	496	12	are	be	VBP
cord-264884-ydkigome	496	13	expanding	expand	VBG
cord-264884-ydkigome	496	14	for	for	IN
cord-264884-ydkigome	496	15	unknown	unknown	JJ
cord-264884-ydkigome	496	16	reasons	reason	NNS
cord-264884-ydkigome	496	17	(	(	-LRB-
cord-264884-ydkigome	496	18	Fleuriet	Fleuriet	NNP
cord-264884-ydkigome	496	19	,	,	,
cord-264884-ydkigome	496	20	1994	1994	CD
cord-264884-ydkigome	496	21	)	)	-RRB-
cord-264884-ydkigome	496	22	.	.	.
cord-264884-ydkigome	497	1	Clearly	clearly	RB
cord-264884-ydkigome	497	2	this	this	DT
cord-264884-ydkigome	497	3	particular	particular	JJ
cord-264884-ydkigome	497	4	virus	virus	NN
cord-264884-ydkigome	497	5	-	-	HYPH
cord-264884-ydkigome	497	6	host	host	NN
cord-264884-ydkigome	497	7	persistent	persistent	JJ
cord-264884-ydkigome	497	8	relationship	relationship	NN
cord-264884-ydkigome	497	9	has	have	VBZ
cord-264884-ydkigome	497	10	some	some	DT
cord-264884-ydkigome	497	11	undefi	undefi	JJ
cord-264884-ydkigome	497	12	ned	ned	NNP
cord-264884-ydkigome	497	13	selective	selective	JJ
cord-264884-ydkigome	497	14	advantage	advantage	NN
cord-264884-ydkigome	497	15	that	that	WDT
cord-264884-ydkigome	497	16	operates	operate	VBZ
cord-264884-ydkigome	497	17	beyond	beyond	IN
cord-264884-ydkigome	497	18	the	the	DT
cord-264884-ydkigome	497	19	lab	lab	NN
cord-264884-ydkigome	497	20	-	-	HYPH
cord-264884-ydkigome	497	21	based	base	VBN
cord-264884-ydkigome	497	22	concepts	concept	NNS
cord-264884-ydkigome	497	23	as	as	IN
cord-264884-ydkigome	497	24	measured	measure	VBN
cord-264884-ydkigome	497	25	above	above	RB
cord-264884-ydkigome	497	26	.	.	.
cord-264884-ydkigome	498	1	Other	other	JJ
cord-264884-ydkigome	498	2	rhabdoviruses	rhabdovirus	NNS
cord-264884-ydkigome	498	3	also	also	RB
cord-264884-ydkigome	498	4	have	have	VBP
cord-264884-ydkigome	498	5	peculiar	peculiar	JJ
cord-264884-ydkigome	498	6	host	host	NN
cord-264884-ydkigome	498	7	-	-	HYPH
cord-264884-ydkigome	498	8	specifi	specifi	VBN
cord-264884-ydkigome	498	9	c	c	NN
cord-264884-ydkigome	498	10	relationships	relationship	NNS
cord-264884-ydkigome	498	11	,	,	,
cord-264884-ydkigome	498	12	such	such	JJ
cord-264884-ydkigome	498	13	as	as	IN
cord-264884-ydkigome	498	14	bats	bat	NNS
cord-264884-ydkigome	498	15	that	that	WDT
cord-264884-ydkigome	498	16	tend	tend	VBP
cord-264884-ydkigome	498	17	to	to	TO
cord-264884-ydkigome	498	18	support	support	VB
cord-264884-ydkigome	498	19	many	many	JJ
cord-264884-ydkigome	498	20	persistent	persistent	JJ
cord-264884-ydkigome	498	21	infections	infection	NNS
cord-264884-ydkigome	498	22	(	(	-LRB-
cord-264884-ydkigome	498	23	Badrane	Badrane	NNP
cord-264884-ydkigome	498	24	and	and	CC
cord-264884-ydkigome	498	25	Tordo	Tordo	NNP
cord-264884-ydkigome	498	26	,	,	,
cord-264884-ydkigome	498	27	2001	2001	CD
cord-264884-ydkigome	498	28	;	;	:
cord-264884-ydkigome	498	29	Li	Li	NNP
cord-264884-ydkigome	498	30	et	et	NNP
cord-264884-ydkigome	498	31	al	al	NNP
cord-264884-ydkigome	498	32	.	.	NNP
cord-264884-ydkigome	498	33	,	,	,
cord-264884-ydkigome	498	34	2005	2005	CD
cord-264884-ydkigome	498	35	)	)	-RRB-
cord-264884-ydkigome	498	36	,	,	,
cord-264884-ydkigome	498	37	or	or	CC
cord-264884-ydkigome	498	38	birds	bird	NNS
cord-264884-ydkigome	498	39	that	that	WDT
cord-264884-ydkigome	498	40	seem	seem	VBP
cord-264884-ydkigome	498	41	to	to	TO
cord-264884-ydkigome	498	42	be	be	VB
cord-264884-ydkigome	498	43	free	free	JJ
cord-264884-ydkigome	498	44	of	of	IN
cord-264884-ydkigome	498	45	almost	almost	RB
cord-264884-ydkigome	498	46	all	all	DT
cord-264884-ydkigome	498	47	rhabdoviruses	rhabdovirus	NNS
cord-264884-ydkigome	498	48	.	.	.
cord-264884-ydkigome	499	1	Clearly	clearly	RB
cord-264884-ydkigome	499	2	,	,	,
cord-264884-ydkigome	499	3	although	although	IN
cord-264884-ydkigome	499	4	VSV	VSV	NNP
cord-264884-ydkigome	499	5	lab	lab	NN
cord-264884-ydkigome	499	6	results	result	NNS
cord-264884-ydkigome	499	7	have	have	VBP
cord-264884-ydkigome	499	8	been	be	VBN
cord-264884-ydkigome	499	9	highly	highly	RB
cord-264884-ydkigome	499	10	informative	informative	JJ
cord-264884-ydkigome	499	11	,	,	,
cord-264884-ydkigome	499	12	we	-PRON-	PRP
cord-264884-ydkigome	499	13	still	still	RB
cord-264884-ydkigome	499	14	have	have	VBP
cord-264884-ydkigome	499	15	much	much	JJ
cord-264884-ydkigome	499	16	to	to	TO
cord-264884-ydkigome	499	17	learn	learn	VB
cord-264884-ydkigome	499	18	regarding	regard	VBG
cord-264884-ydkigome	499	19	natural	natural	JJ
cord-264884-ydkigome	499	20	settings	setting	NNS
cord-264884-ydkigome	499	21	that	that	WDT
cord-264884-ydkigome	499	22	affect	affect	VBP
cord-264884-ydkigome	499	23	rhabdovirus	rhabdovirus	NNP
cord-264884-ydkigome	499	24	adaptation	adaptation	NN
cord-264884-ydkigome	499	25	and	and	CC
cord-264884-ydkigome	499	26	evolution	evolution	NN
cord-264884-ydkigome	499	27	.	.	.
cord-264884-ydkigome	500	1	Another	another	DT
cord-264884-ydkigome	500	2	major	major	JJ
cord-264884-ydkigome	500	3	paradigm	paradigm	NN
cord-264884-ydkigome	500	4	for	for	IN
cord-264884-ydkigome	500	5	the	the	DT
cord-264884-ydkigome	500	6	high	high	JJ
cord-264884-ydkigome	500	7	rates	rate	NNS
cord-264884-ydkigome	500	8	of	of	IN
cord-264884-ydkigome	500	9	negative	negative	JJ
cord-264884-ydkigome	500	10	-	-	HYPH
cord-264884-ydkigome	500	11	strand	strand	NN
cord-264884-ydkigome	500	12	virus	virus	NN
cord-264884-ydkigome	500	13	evolution	evolution	NN
cord-264884-ydkigome	500	14	is	be	VBZ
cord-264884-ydkigome	500	15	found	find	VBN
cord-264884-ydkigome	500	16	with	with	IN
cord-264884-ydkigome	500	17	infl	infl	NNP
cord-264884-ydkigome	500	18	uenza	uenza	NNP
cord-264884-ydkigome	500	19	virus	virus	NN
cord-264884-ydkigome	500	20	.	.	.
cord-264884-ydkigome	501	1	Due	due	IN
cord-264884-ydkigome	501	2	to	to	IN
cord-264884-ydkigome	501	3	its	-PRON-	PRP$
cord-264884-ydkigome	501	4	history	history	NN
cord-264884-ydkigome	501	5	and	and	CC
cord-264884-ydkigome	501	6	potential	potential	NN
cord-264884-ydkigome	501	7	for	for	IN
cord-264884-ydkigome	501	8	initiating	initiate	VBG
cord-264884-ydkigome	501	9	great	great	JJ
cord-264884-ydkigome	501	10	human	human	JJ
cord-264884-ydkigome	501	11	epidemics	epidemic	NNS
cord-264884-ydkigome	501	12	,	,	,
cord-264884-ydkigome	501	13	it	-PRON-	PRP
cord-264884-ydkigome	501	14	has	have	VBZ
cord-264884-ydkigome	501	15	long	long	RB
cord-264884-ydkigome	501	16	held	hold	VBN
cord-264884-ydkigome	501	17	the	the	DT
cord-264884-ydkigome	501	18	special	special	JJ
cord-264884-ydkigome	501	19	interest	interest	NN
cord-264884-ydkigome	501	20	of	of	IN
cord-264884-ydkigome	501	21	evolutionary	evolutionary	JJ
cord-264884-ydkigome	501	22	virologists	virologist	NNS
cord-264884-ydkigome	501	23	(	(	-LRB-
cord-264884-ydkigome	501	24	see	see	VB
cord-264884-ydkigome	501	25	Chapter	chapter	NN
cord-264884-ydkigome	501	26	5	5	CD
cord-264884-ydkigome	501	27	;	;	:
cord-264884-ydkigome	501	28	Nelson	Nelson	NNP
cord-264884-ydkigome	501	29	and	and	CC
cord-264884-ydkigome	501	30	Holmes	Holmes	NNP
cord-264884-ydkigome	501	31	,	,	,
cord-264884-ydkigome	501	32	2007	2007	CD
cord-264884-ydkigome	501	33	)	)	-RRB-
cord-264884-ydkigome	501	34	.	.	.
cord-264884-ydkigome	502	1	However	however	RB
cord-264884-ydkigome	502	2	,	,	,
cord-264884-ydkigome	502	3	this	this	DT
cord-264884-ydkigome	502	4	research	research	NN
cord-264884-ydkigome	502	5	has	have	VBZ
cord-264884-ydkigome	502	6	not	not	RB
cord-264884-ydkigome	502	7	much	much	RB
cord-264884-ydkigome	502	8	emphasized	emphasize	VBN
cord-264884-ydkigome	502	9	the	the	DT
cord-264884-ydkigome	502	10	quasispecies	quasispecies	NNP
cord-264884-ydkigome	502	11	character	character	NN
cord-264884-ydkigome	502	12	of	of	IN
cord-264884-ydkigome	502	13	infl	infl	NNP
cord-264884-ydkigome	502	14	uenza	uenza	NNP
cord-264884-ydkigome	502	15	virus	virus	NN
cord-264884-ydkigome	502	16	evolution	evolution	NN
cord-264884-ydkigome	502	17	.	.	.
cord-264884-ydkigome	503	1	Instead	instead	RB
cord-264884-ydkigome	503	2	,	,	,
cord-264884-ydkigome	503	3	it	-PRON-	PRP
cord-264884-ydkigome	503	4	concentrates	concentrate	VBZ
cord-264884-ydkigome	503	5	on	on	IN
cord-264884-ydkigome	503	6	the	the	DT
cord-264884-ydkigome	503	7	evolution	evolution	NN
cord-264884-ydkigome	503	8	of	of	IN
cord-264884-ydkigome	503	9	the	the	DT
cord-264884-ydkigome	503	10	master	master	NN
cord-264884-ydkigome	503	11	template	template	NN
cord-264884-ydkigome	503	12	or	or	CC
cord-264884-ydkigome	503	13	clades	clade	NNS
cord-264884-ydkigome	503	14	of	of	IN
cord-264884-ydkigome	503	15	template	template	NN
cord-264884-ydkigome	503	16	for	for	IN
cord-264884-ydkigome	503	17	the	the	DT
cord-264884-ydkigome	503	18	purposes	purpose	NNS
cord-264884-ydkigome	503	19	of	of	IN
cord-264884-ydkigome	503	20	vaccine	vaccine	NN
cord-264884-ydkigome	503	21	development	development	NN
cord-264884-ydkigome	503	22	(	(	-LRB-
cord-264884-ydkigome	503	23	Webster	Webster	NNP
cord-264884-ydkigome	503	24	and	and	CC
cord-264884-ydkigome	503	25	Govorkova	Govorkova	NNP
cord-264884-ydkigome	503	26	,	,	,
cord-264884-ydkigome	503	27	2006	2006	CD
cord-264884-ydkigome	503	28	)	)	-RRB-
cord-264884-ydkigome	503	29	.	.	.
cord-264884-ydkigome	504	1	The	the	DT
cord-264884-ydkigome	504	2	views	view	NNS
cord-264884-ydkigome	504	3	stemming	stem	VBG
cord-264884-ydkigome	504	4	from	from	IN
cord-264884-ydkigome	504	5	this	this	DT
cord-264884-ydkigome	504	6	type	type	NN
cord-264884-ydkigome	504	7	of	of	IN
cord-264884-ydkigome	504	8	evolution	evolution	NN
cord-264884-ydkigome	504	9	have	have	VBP
cord-264884-ydkigome	504	10	lent	lend	VBN
cord-264884-ydkigome	504	11	themselves	-PRON-	PRP
cord-264884-ydkigome	504	12	well	well	JJ
cord-264884-ydkigome	504	13	to	to	TO
cord-264884-ydkigome	504	14	master	master	VB
cord-264884-ydkigome	504	15	template	template	NN
cord-264884-ydkigome	504	16	-	-	HYPH
cord-264884-ydkigome	504	17	based	base	VBN
cord-264884-ydkigome	504	18	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	504	19	analysis	analysis	NN
cord-264884-ydkigome	504	20	and	and	CC
cord-264884-ydkigome	504	21	have	have	VBP
cord-264884-ydkigome	504	22	dominated	dominate	VBN
cord-264884-ydkigome	504	23	how	how	WRB
cord-264884-ydkigome	504	24	many	many	JJ
cord-264884-ydkigome	504	25	researchers	researcher	NNS
cord-264884-ydkigome	504	26	think	think	VBP
cord-264884-ydkigome	504	27	of	of	IN
cord-264884-ydkigome	504	28	virus	virus	NN
cord-264884-ydkigome	504	29	-	-	HYPH
cord-264884-ydkigome	504	30	host	host	NN
cord-264884-ydkigome	504	31	evolution	evolution	NN
cord-264884-ydkigome	504	32	.	.	.
cord-264884-ydkigome	505	1	Thus	thus	RB
cord-264884-ydkigome	505	2	it	-PRON-	PRP
cord-264884-ydkigome	505	3	is	be	VBZ
cord-264884-ydkigome	505	4	curious	curious	JJ
cord-264884-ydkigome	505	5	,	,	,
cord-264884-ydkigome	505	6	given	give	VBN
cord-264884-ydkigome	505	7	the	the	DT
cord-264884-ydkigome	505	8	above	above	JJ
cord-264884-ydkigome	505	9	emphasis	emphasis	NN
cord-264884-ydkigome	505	10	,	,	,
cord-264884-ydkigome	505	11	that	that	IN
cord-264884-ydkigome	505	12	the	the	DT
cord-264884-ydkigome	505	13	quasispecies	quasispecies	NNP
cord-264884-ydkigome	505	14	character	character	NN
cord-264884-ydkigome	505	15	of	of	IN
cord-264884-ydkigome	505	16	infl	infl	NNP
cord-264884-ydkigome	505	17	uenza	uenza	NNP
cord-264884-ydkigome	505	18	populations	population	NNS
cord-264884-ydkigome	505	19	often	often	RB
cord-264884-ydkigome	505	20	seems	seem	VBZ
cord-264884-ydkigome	505	21	of	of	IN
cord-264884-ydkigome	505	22	low	low	JJ
cord-264884-ydkigome	505	23	relevance	relevance	NN
cord-264884-ydkigome	505	24	to	to	IN
cord-264884-ydkigome	505	25	issues	issue	NNS
cord-264884-ydkigome	505	26	of	of	IN
cord-264884-ydkigome	505	27	acute	acute	JJ
cord-264884-ydkigome	505	28	disease	disease	NN
cord-264884-ydkigome	505	29	and	and	CC
cord-264884-ydkigome	505	30	vaccination	vaccination	NN
cord-264884-ydkigome	505	31	,	,	,
cord-264884-ydkigome	505	32	other	other	JJ
cord-264884-ydkigome	505	33	then	then	RB
cord-264884-ydkigome	505	34	to	to	TO
cord-264884-ydkigome	505	35	provide	provide	VB
cord-264884-ydkigome	505	36	a	a	DT
cord-264884-ydkigome	505	37	source	source	NN
cord-264884-ydkigome	505	38	of	of	IN
cord-264884-ydkigome	505	39	diversity	diversity	NN
cord-264884-ydkigome	505	40	.	.	.
cord-264884-ydkigome	506	1	In	in	IN
cord-264884-ydkigome	506	2	some	some	DT
cord-264884-ydkigome	506	3	situations	situation	NNS
cord-264884-ydkigome	506	4	,	,	,
cord-264884-ydkigome	506	5	viral	viral	JJ
cord-264884-ydkigome	506	6	competitive	competitive	JJ
cord-264884-ydkigome	506	7	interference	interference	NN
cord-264884-ydkigome	506	8	may	may	MD
cord-264884-ydkigome	506	9	contribute	contribute	VB
cord-264884-ydkigome	506	10	to	to	TO
cord-264884-ydkigome	506	11	drift	drift	VB
cord-264884-ydkigome	506	12	variation	variation	NN
cord-264884-ydkigome	506	13	and	and	CC
cord-264884-ydkigome	506	14	displacement	displacement	NN
cord-264884-ydkigome	506	15	in	in	IN
cord-264884-ydkigome	506	16	antigenic	antigenic	JJ
cord-264884-ydkigome	506	17	epitopes	epitope	NNS
cord-264884-ydkigome	507	1	(	(	-LRB-
cord-264884-ydkigome	507	2	Levin	Levin	NNP
cord-264884-ydkigome	507	3	et	et	NNP
cord-264884-ydkigome	507	4	al	al	NNP
cord-264884-ydkigome	507	5	.	.	NNP
cord-264884-ydkigome	507	6	,	,	,
cord-264884-ydkigome	507	7	2004	2004	CD
cord-264884-ydkigome	507	8	)	)	-RRB-
cord-264884-ydkigome	507	9	.	.	.
cord-264884-ydkigome	508	1	Yet	yet	CC
cord-264884-ydkigome	508	2	outcomes	outcome	NNS
cord-264884-ydkigome	508	3	of	of	IN
cord-264884-ydkigome	508	4	individual	individual	JJ
cord-264884-ydkigome	508	5	human	human	NN
cord-264884-ydkigome	508	6	and	and	CC
cord-264884-ydkigome	508	7	bird	bird	NN
cord-264884-ydkigome	508	8	infections	infection	NNS
cord-264884-ydkigome	508	9	do	do	VBP
cord-264884-ydkigome	508	10	not	not	RB
cord-264884-ydkigome	508	11	seem	seem	VB
cord-264884-ydkigome	508	12	much	much	RB
cord-264884-ydkigome	508	13	affected	affect	VBN
cord-264884-ydkigome	508	14	by	by	IN
cord-264884-ydkigome	508	15	specifi	specifi	NNP
cord-264884-ydkigome	508	16	c	c	NNP
cord-264884-ydkigome	508	17	quasispecies	quasispecies	NNP
cord-264884-ydkigome	508	18	structures	structure	NNS
cord-264884-ydkigome	508	19	,	,	,
cord-264884-ydkigome	508	20	as	as	IN
cord-264884-ydkigome	508	21	we	-PRON-	PRP
cord-264884-ydkigome	508	22	saw	see	VBD
cord-264884-ydkigome	508	23	with	with	IN
cord-264884-ydkigome	508	24	HIV-1	HIV-1	NNP
cord-264884-ydkigome	508	25	and	and	CC
cord-264884-ydkigome	508	26	HCV	HCV	NNP
cord-264884-ydkigome	508	27	.	.	.
cord-264884-ydkigome	509	1	With	with	IN
cord-264884-ydkigome	509	2	infl	infl	NNP
cord-264884-ydkigome	509	3	uenza	uenza	NNP
cord-264884-ydkigome	509	4	,	,	,
cord-264884-ydkigome	509	5	we	-PRON-	PRP
cord-264884-ydkigome	509	6	are	be	VBP
cord-264884-ydkigome	509	7	mainly	mainly	RB
cord-264884-ydkigome	509	8	concerned	concern	VBN
cord-264884-ydkigome	509	9	with	with	IN
cord-264884-ydkigome	509	10	epidemic	epidemic	JJ
cord-264884-ydkigome	509	11	human	human	JJ
cord-264884-ydkigome	509	12	disease	disease	NN
cord-264884-ydkigome	509	13	.	.	.
cord-264884-ydkigome	510	1	However	however	RB
cord-264884-ydkigome	510	2	,	,	,
cord-264884-ydkigome	510	3	by	by	IN
cord-264884-ydkigome	510	4	shear	shear	NN
cord-264884-ydkigome	510	5	numbers	number	NNS
cord-264884-ydkigome	510	6	of	of	IN
cord-264884-ydkigome	510	7	infections	infection	NNS
cord-264884-ydkigome	510	8	and	and	CC
cord-264884-ydkigome	510	9	deaths	death	NNS
cord-264884-ydkigome	510	10	worldwide	worldwide	RB
cord-264884-ydkigome	510	11	,	,	,
cord-264884-ydkigome	510	12	it	-PRON-	PRP
cord-264884-ydkigome	510	13	must	must	MD
cord-264884-ydkigome	510	14	be	be	VB
cord-264884-ydkigome	510	15	admitted	admit	VBN
cord-264884-ydkigome	510	16	that	that	IN
cord-264884-ydkigome	510	17	infl	infl	NNP
cord-264884-ydkigome	510	18	uenza	uenza	NNP
cord-264884-ydkigome	510	19	virus	virus	NN
cord-264884-ydkigome	510	20	is	be	VBZ
cord-264884-ydkigome	510	21	really	really	RB
cord-264884-ydkigome	510	22	a	a	DT
cord-264884-ydkigome	510	23	virus	virus	NN
cord-264884-ydkigome	510	24	that	that	WDT
cord-264884-ydkigome	510	25	affects	affect	VBZ
cord-264884-ydkigome	510	26	mostly	mostly	RB
cord-264884-ydkigome	510	27	birds	bird	NNS
cord-264884-ydkigome	510	28	.	.	.
cord-264884-ydkigome	511	1	For	for	IN
cord-264884-ydkigome	511	2	example	example	NN
cord-264884-ydkigome	511	3	,	,	,
cord-264884-ydkigome	511	4	during	during	IN
cord-264884-ydkigome	511	5	the	the	DT
cord-264884-ydkigome	511	6	2005	2005	CD
cord-264884-ydkigome	511	7	outbreak	outbreak	NN
cord-264884-ydkigome	511	8	in	in	IN
cord-264884-ydkigome	511	9	China	China	NNP
cord-264884-ydkigome	511	10	,	,	,
cord-264884-ydkigome	511	11	only	only	RB
cord-264884-ydkigome	511	12	251	251	CD
cord-264884-ydkigome	511	13	humans	human	NNS
cord-264884-ydkigome	511	14	died	die	VBD
cord-264884-ydkigome	511	15	whereas	whereas	IN
cord-264884-ydkigome	511	16	230	230	CD
cord-264884-ydkigome	511	17	million	million	CD
cord-264884-ydkigome	511	18	domestic	domestic	JJ
cord-264884-ydkigome	511	19	birds	bird	NNS
cord-264884-ydkigome	511	20	died	die	VBD
cord-264884-ydkigome	511	21	(	(	-LRB-
cord-264884-ydkigome	511	22	Smith	Smith	NNP
cord-264884-ydkigome	511	23	et	et	NNP
cord-264884-ydkigome	511	24	al	al	NNP
cord-264884-ydkigome	511	25	.	.	NNP
cord-264884-ydkigome	511	26	,	,	,
cord-264884-ydkigome	511	27	2006	2006	CD
cord-264884-ydkigome	511	28	)	)	-RRB-
cord-264884-ydkigome	511	29	.	.	.
cord-264884-ydkigome	512	1	Although	although	IN
cord-264884-ydkigome	512	2	our	-PRON-	PRP$
cord-264884-ydkigome	512	3	concern	concern	NN
cord-264884-ydkigome	512	4	on	on	IN
cord-264884-ydkigome	512	5	the	the	DT
cord-264884-ydkigome	512	6	large	large	JJ
cord-264884-ydkigome	512	7	potential	potential	NN
cord-264884-ydkigome	512	8	for	for	IN
cord-264884-ydkigome	512	9	human	human	JJ
cord-264884-ydkigome	512	10	disease	disease	NN
cord-264884-ydkigome	512	11	is	be	VBZ
cord-264884-ydkigome	512	12	understandable	understandable	JJ
cord-264884-ydkigome	512	13	,	,	,
cord-264884-ydkigome	512	14	these	these	DT
cord-264884-ydkigome	512	15	numbers	number	NNS
cord-264884-ydkigome	512	16	should	should	MD
cord-264884-ydkigome	512	17	inform	inform	VB
cord-264884-ydkigome	512	18	us	-PRON-	PRP
cord-264884-ydkigome	512	19	of	of	IN
cord-264884-ydkigome	512	20	a	a	DT
cord-264884-ydkigome	512	21	more	more	RBR
cord-264884-ydkigome	512	22	basic	basic	JJ
cord-264884-ydkigome	512	23	virushost	virushost	NN
cord-264884-ydkigome	512	24	biology	biology	NN
cord-264884-ydkigome	512	25	.	.	.
cord-264884-ydkigome	513	1	In	in	IN
cord-264884-ydkigome	513	2	this	this	DT
cord-264884-ydkigome	513	3	case	case	NN
cord-264884-ydkigome	513	4	,	,	,
cord-264884-ydkigome	513	5	infl	infl	NNP
cord-264884-ydkigome	513	6	uenza	uenza	NNP
cord-264884-ydkigome	513	7	shows	show	VBZ
cord-264884-ydkigome	513	8	a	a	DT
cord-264884-ydkigome	513	9	high	high	JJ
cord-264884-ydkigome	513	10	affi	affi	JJ
cord-264884-ydkigome	513	11	nity	nity	NN
cord-264884-ydkigome	513	12	for	for	IN
cord-264884-ydkigome	513	13	various	various	JJ
cord-264884-ydkigome	513	14	birds	bird	NNS
cord-264884-ydkigome	513	15	;	;	:
cord-264884-ydkigome	513	16	migratory	migratory	JJ
cord-264884-ydkigome	513	17	water	water	NN
cord-264884-ydkigome	513	18	birds	bird	NNS
cord-264884-ydkigome	513	19	in	in	IN
cord-264884-ydkigome	513	20	particular	particular	JJ
cord-264884-ydkigome	513	21	can	can	MD
cord-264884-ydkigome	513	22	have	have	VB
cord-264884-ydkigome	513	23	high	high	JJ
cord-264884-ydkigome	513	24	prevalence	prevalence	NN
cord-264884-ydkigome	513	25	(	(	-LRB-
cord-264884-ydkigome	513	26	Wallensten	Wallensten	NNP
cord-264884-ydkigome	513	27	et	et	NNP
cord-264884-ydkigome	513	28	al	al	NNP
cord-264884-ydkigome	513	29	.	.	NNP
cord-264884-ydkigome	513	30	,	,	,
cord-264884-ydkigome	513	31	2006	2006	CD
cord-264884-ydkigome	513	32	)	)	-RRB-
cord-264884-ydkigome	513	33	.	.	.
cord-264884-ydkigome	514	1	Some	some	DT
cord-264884-ydkigome	514	2	waterfowl	waterfowl	NNS
cord-264884-ydkigome	514	3	,	,	,
cord-264884-ydkigome	514	4	such	such	JJ
cord-264884-ydkigome	514	5	as	as	IN
cord-264884-ydkigome	514	6	wild	wild	JJ
cord-264884-ydkigome	514	7	mallard	mallard	NN
cord-264884-ydkigome	514	8	ducks	duck	NNS
cord-264884-ydkigome	514	9	,	,	,
cord-264884-ydkigome	514	10	have	have	VBP
cord-264884-ydkigome	514	11	been	be	VBN
cord-264884-ydkigome	514	12	called	call	VBN
cord-264884-ydkigome	514	13	the	the	DT
cord-264884-ydkigome	514	14	stealth	stealth	NN
cord-264884-ydkigome	514	15	(	(	-LRB-
cord-264884-ydkigome	514	16	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	514	17	)	)	-RRB-
cord-264884-ydkigome	514	18	carriers	carrier	NNS
cord-264884-ydkigome	514	19	of	of	IN
cord-264884-ydkigome	514	20	infl	infl	NN
cord-264884-ydkigome	514	21	uenza	uenza	NNP
cord-264884-ydkigome	514	22	H5N1	H5N1	NNP
cord-264884-ydkigome	514	23	and	and	CC
cord-264884-ydkigome	514	24	free	free	JJ
cord-264884-ydkigome	514	25	grazing	grazing	NN
cord-264884-ydkigome	514	26	ducks	duck	NNS
cord-264884-ydkigome	514	27	seem	seem	VBP
cord-264884-ydkigome	514	28	to	to	TO
cord-264884-ydkigome	514	29	introduce	introduce	VB
cord-264884-ydkigome	514	30	virus	virus	NN
cord-264884-ydkigome	514	31	into	into	IN
cord-264884-ydkigome	514	32	domestic	domestic	JJ
cord-264884-ydkigome	514	33	bird	bird	NN
cord-264884-ydkigome	514	34	populations	population	NNS
cord-264884-ydkigome	515	1	(	(	-LRB-
cord-264884-ydkigome	515	2	Gilbert	Gilbert	NNP
cord-264884-ydkigome	515	3	et	et	NNP
cord-264884-ydkigome	515	4	al	al	NNP
cord-264884-ydkigome	515	5	.	.	NNP
cord-264884-ydkigome	515	6	,	,	,
cord-264884-ydkigome	515	7	2006	2006	CD
cord-264884-ydkigome	515	8	)	)	-RRB-
cord-264884-ydkigome	515	9	.	.	.
cord-264884-ydkigome	516	1	Thus	thus	RB
cord-264884-ydkigome	516	2	waterfowl	waterfowl	NNS
cord-264884-ydkigome	516	3	represent	represent	VBP
cord-264884-ydkigome	516	4	the	the	DT
cord-264884-ydkigome	516	5	well	well	RB
cord-264884-ydkigome	516	6	-	-	HYPH
cord-264884-ydkigome	516	7	accepted	accept	VBN
cord-264884-ydkigome	516	8	epidemiological	epidemiological	JJ
cord-264884-ydkigome	516	9	concept	concept	NN
cord-264884-ydkigome	516	10	of	of	IN
cord-264884-ydkigome	516	11	a	a	DT
cord-264884-ydkigome	516	12	reservoir	reservoir	NN
cord-264884-ydkigome	516	13	species	specie	NNS
cord-264884-ydkigome	516	14	(	(	-LRB-
cord-264884-ydkigome	516	15	Louz	Louz	NNP
cord-264884-ydkigome	516	16	et	et	FW
cord-264884-ydkigome	516	17	al	al	NNP
cord-264884-ydkigome	516	18	.	.	NNP
cord-264884-ydkigome	516	19	,	,	,
cord-264884-ydkigome	516	20	2005	2005	CD
cord-264884-ydkigome	516	21	)	)	-RRB-
cord-264884-ydkigome	516	22	.	.	.
cord-264884-ydkigome	517	1	But	but	CC
cord-264884-ydkigome	517	2	these	these	DT
cord-264884-ydkigome	517	3	wild	wild	JJ
cord-264884-ydkigome	517	4	waterfowl	waterfowl	NNS
cord-264884-ydkigome	517	5	,	,	,
cord-264884-ydkigome	517	6	shorebirds	shorebird	NNS
cord-264884-ydkigome	517	7	,	,	,
cord-264884-ydkigome	517	8	and	and	CC
cord-264884-ydkigome	517	9	gulls	gull	NNS
cord-264884-ydkigome	517	10	that	that	WDT
cord-264884-ydkigome	517	11	are	be	VBP
cord-264884-ydkigome	517	12	a	a	DT
cord-264884-ydkigome	517	13	natural	natural	JJ
cord-264884-ydkigome	517	14	host	host	NN
cord-264884-ydkigome	517	15	for	for	IN
cord-264884-ydkigome	517	16	avian	avian	JJ
cord-264884-ydkigome	517	17	infl	infl	NN
cord-264884-ydkigome	517	18	uenza	uenza	NNP
cord-264884-ydkigome	517	19	also	also	RB
cord-264884-ydkigome	517	20	seem	seem	VBP
cord-264884-ydkigome	517	21	to	to	TO
cord-264884-ydkigome	517	22	show	show	VB
cord-264884-ydkigome	517	23	a	a	DT
cord-264884-ydkigome	517	24	much	much	RB
cord-264884-ydkigome	517	25	slower	slow	JJR
cord-264884-ydkigome	517	26	rate	rate	NN
cord-264884-ydkigome	517	27	of	of	IN
cord-264884-ydkigome	517	28	evolution	evolution	NN
cord-264884-ydkigome	517	29	(	(	-LRB-
cord-264884-ydkigome	517	30	Spackman	Spackman	NNP
cord-264884-ydkigome	517	31	et	et	NNP
cord-264884-ydkigome	517	32	al	al	NNP
cord-264884-ydkigome	517	33	.	.	NNP
cord-264884-ydkigome	517	34	,	,	,
cord-264884-ydkigome	517	35	2005	2005	CD
cord-264884-ydkigome	517	36	)	)	-RRB-
cord-264884-ydkigome	517	37	.	.	.
cord-264884-ydkigome	518	1	In	in	IN
cord-264884-ydkigome	518	2	contrast	contrast	NN
cord-264884-ydkigome	518	3	,	,	,
cord-264884-ydkigome	518	4	the	the	DT
cord-264884-ydkigome	518	5	much	much	RB
cord-264884-ydkigome	518	6	higher	high	JJR
cord-264884-ydkigome	518	7	rate	rate	NN
cord-264884-ydkigome	518	8	of	of	IN
cord-264884-ydkigome	518	9	evolution	evolution	NN
cord-264884-ydkigome	518	10	as	as	IN
cord-264884-ydkigome	518	11	seen	see	VBN
cord-264884-ydkigome	518	12	in	in	IN
cord-264884-ydkigome	518	13	chickens	chicken	NNS
cord-264884-ydkigome	518	14	and	and	CC
cord-264884-ydkigome	518	15	turkeys	turkey	NNS
cord-264884-ydkigome	518	16	indicates	indicate	VBZ
cord-264884-ydkigome	518	17	that	that	IN
cord-264884-ydkigome	518	18	these	these	DT
cord-264884-ydkigome	518	19	hosts	host	NNS
cord-264884-ydkigome	518	20	should	should	MD
cord-264884-ydkigome	518	21	not	not	RB
cord-264884-ydkigome	518	22	be	be	VB
cord-264884-ydkigome	518	23	considered	consider	VBN
cord-264884-ydkigome	518	24	as	as	IN
cord-264884-ydkigome	518	25	natural	natural	JJ
cord-264884-ydkigome	518	26	reservoirs	reservoir	NNS
cord-264884-ydkigome	518	27	(	(	-LRB-
cord-264884-ydkigome	518	28	Suarez	Suarez	NNP
cord-264884-ydkigome	518	29	,	,	,
cord-264884-ydkigome	518	30	2000	2000	CD
cord-264884-ydkigome	518	31	)	)	-RRB-
cord-264884-ydkigome	518	32	.	.	.
cord-264884-ydkigome	519	1	In	in	IN
cord-264884-ydkigome	519	2	waterfowl	waterfowl	NN
cord-264884-ydkigome	519	3	,	,	,
cord-264884-ydkigome	519	4	infl	infl	NN
cord-264884-ydkigome	519	5	uenza	uenza	NNP
cord-264884-ydkigome	519	6	infections	infection	NNS
cord-264884-ydkigome	519	7	show	show	VBP
cord-264884-ydkigome	519	8	several	several	JJ
cord-264884-ydkigome	519	9	distinctions	distinction	NNS
cord-264884-ydkigome	519	10	,	,	,
cord-264884-ydkigome	519	11	such	such	JJ
cord-264884-ydkigome	519	12	as	as	IN
cord-264884-ydkigome	519	13	virus	virus	NN
cord-264884-ydkigome	519	14	co	co	NN
cord-264884-ydkigome	519	15	-	-	NN
cord-264884-ydkigome	519	16	infection	infection	NN
cord-264884-ydkigome	519	17	or	or	CC
cord-264884-ydkigome	519	18	virus	virus	NN
cord-264884-ydkigome	519	19	interference	interference	NN
cord-264884-ydkigome	519	20	(	(	-LRB-
cord-264884-ydkigome	519	21	Sharp	Sharp	NNP
cord-264884-ydkigome	519	22	et	et	FW
cord-264884-ydkigome	519	23	al	al	NNP
cord-264884-ydkigome	519	24	.	.	NNP
cord-264884-ydkigome	519	25	,	,	,
cord-264884-ydkigome	519	26	1997	1997	CD
cord-264884-ydkigome	519	27	)	)	-RRB-
cord-264884-ydkigome	519	28	as	as	RB
cord-264884-ydkigome	519	29	well	well	RB
cord-264884-ydkigome	519	30	as	as	IN
cord-264884-ydkigome	519	31	phylogenetically	phylogenetically	RB
cord-264884-ydkigome	519	32	distinguishable	distinguishable	JJ
cord-264884-ydkigome	519	33	waterfowl	waterfowl	NN
cord-264884-ydkigome	519	34	dendograms	dendogram	NNS
cord-264884-ydkigome	519	35	,	,	,
cord-264884-ydkigome	519	36	including	include	VBG
cord-264884-ydkigome	519	37	specifi	specifi	NNP
cord-264884-ydkigome	519	38	c	c	NN
cord-264884-ydkigome	519	39	M	m	CD
cord-264884-ydkigome	519	40	lineages	lineage	NNS
cord-264884-ydkigome	520	1	(	(	-LRB-
cord-264884-ydkigome	520	2	Makarova	Makarova	NNP
cord-264884-ydkigome	520	3	et	et	NNP
cord-264884-ydkigome	520	4	al	al	NNP
cord-264884-ydkigome	520	5	.	.	.
cord-264884-ydkigome	521	1	,	,	,
cord-264884-ydkigome	521	2	1998	1998	CD
cord-264884-ydkigome	521	3	;	;	:
cord-264884-ydkigome	521	4	Widjaja	Widjaja	NNP
cord-264884-ydkigome	521	5	et	et	NNP
cord-264884-ydkigome	521	6	al	al	NNP
cord-264884-ydkigome	521	7	.	.	NNP
cord-264884-ydkigome	521	8	,	,	,
cord-264884-ydkigome	521	9	2004	2004	CD
cord-264884-ydkigome	521	10	)	)	-RRB-
cord-264884-ydkigome	521	11	.	.	.
cord-264884-ydkigome	522	1	The	the	DT
cord-264884-ydkigome	522	2	diverse	diverse	JJ
cord-264884-ydkigome	522	3	and	and	CC
cord-264884-ydkigome	522	4	stable	stable	JJ
cord-264884-ydkigome	522	5	avian	avian	JJ
cord-264884-ydkigome	522	6	pool	pool	NN
cord-264884-ydkigome	522	7	of	of	IN
cord-264884-ydkigome	522	8	infl	infl	NNP
cord-264884-ydkigome	522	9	uenza	uenza	NNP
cord-264884-ydkigome	522	10	virus	virus	NN
cord-264884-ydkigome	522	11	appears	appear	VBZ
cord-264884-ydkigome	522	12	to	to	TO
cord-264884-ydkigome	522	13	be	be	VB
cord-264884-ydkigome	522	14	ancestral	ancestral	JJ
cord-264884-ydkigome	522	15	to	to	IN
cord-264884-ydkigome	522	16	the	the	DT
cord-264884-ydkigome	522	17	infl	infl	NN
cord-264884-ydkigome	522	18	uenza	uenza	NN
cord-264884-ydkigome	522	19	viruses	virus	NNS
cord-264884-ydkigome	522	20	that	that	WDT
cord-264884-ydkigome	522	21	infected	infect	VBD
cord-264884-ydkigome	522	22	human	human	JJ
cord-264884-ydkigome	522	23	populations	population	NNS
cord-264884-ydkigome	522	24	.	.	.
cord-264884-ydkigome	523	1	The	the	DT
cord-264884-ydkigome	523	2	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	523	3	methods	method	NNS
cord-264884-ydkigome	523	4	that	that	WDT
cord-264884-ydkigome	523	5	have	have	VBP
cord-264884-ydkigome	523	6	been	be	VBN
cord-264884-ydkigome	523	7	adapted	adapt	VBN
cord-264884-ydkigome	523	8	from	from	IN
cord-264884-ydkigome	523	9	evolutionary	evolutionary	JJ
cord-264884-ydkigome	523	10	biology	biology	NN
cord-264884-ydkigome	523	11	have	have	VBP
cord-264884-ydkigome	523	12	been	be	VBN
cord-264884-ydkigome	523	13	tremendously	tremendously	RB
cord-264884-ydkigome	523	14	helpful	helpful	JJ
cord-264884-ydkigome	523	15	and	and	CC
cord-264884-ydkigome	523	16	have	have	VBP
cord-264884-ydkigome	523	17	allowed	allow	VBN
cord-264884-ydkigome	523	18	us	-PRON-	PRP
cord-264884-ydkigome	523	19	to	to	TO
cord-264884-ydkigome	523	20	trace	trace	VB
cord-264884-ydkigome	523	21	the	the	DT
cord-264884-ydkigome	523	22	seemingly	seemingly	RB
cord-264884-ydkigome	523	23	untraceable	untraceable	JJ
cord-264884-ydkigome	523	24	,	,	,
cord-264884-ydkigome	523	25	virus	virus	NN
cord-264884-ydkigome	523	26	evolution	evolution	NN
cord-264884-ydkigome	523	27	(	(	-LRB-
cord-264884-ydkigome	523	28	see	see	VB
cord-264884-ydkigome	523	29	Chapter	chapter	NN
cord-264884-ydkigome	523	30	5	5	CD
cord-264884-ydkigome	523	31	)	)	-RRB-
cord-264884-ydkigome	523	32	.	.	.
cord-264884-ydkigome	524	1	Thus	thus	RB
cord-264884-ydkigome	524	2	,	,	,
cord-264884-ydkigome	524	3	we	-PRON-	PRP
cord-264884-ydkigome	524	4	have	have	VBP
cord-264884-ydkigome	524	5	often	often	RB
cord-264884-ydkigome	524	6	been	be	VBN
cord-264884-ydkigome	524	7	able	able	JJ
cord-264884-ydkigome	524	8	to	to	TO
cord-264884-ydkigome	524	9	make	make	VB
cord-264884-ydkigome	524	10	informed	informed	JJ
cord-264884-ydkigome	524	11	judgments	judgment	NNS
cord-264884-ydkigome	524	12	concerning	concern	VBG
cord-264884-ydkigome	524	13	broader	broad	JJR
cord-264884-ydkigome	524	14	patterns	pattern	NNS
cord-264884-ydkigome	524	15	of	of	IN
cord-264884-ydkigome	524	16	virus	virus	NN
cord-264884-ydkigome	524	17	evolution	evolution	NN
cord-264884-ydkigome	524	18	and	and	CC
cord-264884-ydkigome	524	19	this	this	DT
cord-264884-ydkigome	524	20	has	have	VBZ
cord-264884-ydkigome	524	21	become	become	VBN
cord-264884-ydkigome	524	22	the	the	DT
cord-264884-ydkigome	524	23	major	major	JJ
cord-264884-ydkigome	524	24	tool	tool	NN
cord-264884-ydkigome	524	25	for	for	IN
cord-264884-ydkigome	524	26	the	the	DT
cord-264884-ydkigome	524	27	current	current	JJ
cord-264884-ydkigome	524	28	study	study	NN
cord-264884-ydkigome	524	29	of	of	IN
cord-264884-ydkigome	524	30	virus	virus	NN
cord-264884-ydkigome	524	31	evolution	evolution	NN
cord-264884-ydkigome	524	32	,	,	,
cord-264884-ydkigome	524	33	such	such	JJ
cord-264884-ydkigome	524	34	as	as	IN
cord-264884-ydkigome	524	35	infl	infl	NNP
cord-264884-ydkigome	524	36	uenza	uenza	NNP
cord-264884-ydkigome	524	37	virus	virus	NN
cord-264884-ydkigome	524	38	(	(	-LRB-
cord-264884-ydkigome	524	39	Nelson	Nelson	NNP
cord-264884-ydkigome	524	40	and	and	CC
cord-264884-ydkigome	524	41	Holmes	Holmes	NNP
cord-264884-ydkigome	524	42	,	,	,
cord-264884-ydkigome	524	43	2007	2007	CD
cord-264884-ydkigome	524	44	)	)	-RRB-
cord-264884-ydkigome	524	45	.	.	.
cord-264884-ydkigome	525	1	Infl	Infl	NNP
cord-264884-ydkigome	525	2	uenza	uenza	NNP
cord-264884-ydkigome	525	3	A	A	NNP
cord-264884-ydkigome	525	4	,	,	,
cord-264884-ydkigome	525	5	for	for	IN
cord-264884-ydkigome	525	6	example	example	NN
cord-264884-ydkigome	525	7	can	can	MD
cord-264884-ydkigome	525	8	be	be	VB
cord-264884-ydkigome	525	9	seen	see	VBN
cord-264884-ydkigome	525	10	to	to	TO
cord-264884-ydkigome	525	11	show	show	VB
cord-264884-ydkigome	525	12	extended	extended	JJ
cord-264884-ydkigome	525	13	periods	period	NNS
cord-264884-ydkigome	525	14	of	of	IN
cord-264884-ydkigome	525	15	stasis	stasis	NN
cord-264884-ydkigome	525	16	followed	follow	VBN
cord-264884-ydkigome	525	17	by	by	IN
cord-264884-ydkigome	525	18	periods	period	NNS
cord-264884-ydkigome	525	19	of	of	IN
cord-264884-ydkigome	525	20	rapid	rapid	JJ
cord-264884-ydkigome	525	21	adaptation	adaptation	NN
cord-264884-ydkigome	525	22	that	that	WDT
cord-264884-ydkigome	525	23	necessitates	necessitate	VBZ
cord-264884-ydkigome	525	24	adaptations	adaptation	NNS
cord-264884-ydkigome	525	25	in	in	IN
cord-264884-ydkigome	525	26	vaccine	vaccine	NN
cord-264884-ydkigome	525	27	strategy	strategy	NN
cord-264884-ydkigome	525	28	(	(	-LRB-
cord-264884-ydkigome	525	29	Wolf	Wolf	NNP
cord-264884-ydkigome	525	30	et	et	FW
cord-264884-ydkigome	525	31	al	al	NNP
cord-264884-ydkigome	525	32	.	.	NNP
cord-264884-ydkigome	525	33	,	,	,
cord-264884-ydkigome	525	34	2006	2006	CD
cord-264884-ydkigome	525	35	)	)	-RRB-
cord-264884-ydkigome	525	36	.	.	.
cord-264884-ydkigome	526	1	However	however	RB
cord-264884-ydkigome	526	2	,	,	,
cord-264884-ydkigome	526	3	the	the	DT
cord-264884-ydkigome	526	4	evolutionary	evolutionary	JJ
cord-264884-ydkigome	526	5	variation	variation	NN
cord-264884-ydkigome	526	6	between	between	IN
cord-264884-ydkigome	526	7	seemingly	seemingly	RB
cord-264884-ydkigome	526	8	similar	similar	JJ
cord-264884-ydkigome	526	9	viruses	virus	NNS
cord-264884-ydkigome	526	10	can	can	MD
cord-264884-ydkigome	526	11	be	be	VB
cord-264884-ydkigome	526	12	surprisingly	surprisingly	RB
cord-264884-ydkigome	526	13	large	large	JJ
cord-264884-ydkigome	526	14	(	(	-LRB-
cord-264884-ydkigome	526	15	see	see	VB
cord-264884-ydkigome	526	16	above	above	IN
cord-264884-ydkigome	526	17	VSV	VSV	NNP
cord-264884-ydkigome	526	18	section	section	NN
cord-264884-ydkigome	526	19	)	)	-RRB-
cord-264884-ydkigome	526	20	.	.	.
cord-264884-ydkigome	527	1	For	for	IN
cord-264884-ydkigome	527	2	example	example	NN
cord-264884-ydkigome	527	3	,	,	,
cord-264884-ydkigome	527	4	the	the	DT
cord-264884-ydkigome	527	5	very	very	RB
cord-264884-ydkigome	527	6	different	different	JJ
cord-264884-ydkigome	527	7	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	527	8	behaviors	behavior	NNS
cord-264884-ydkigome	527	9	between	between	IN
cord-264884-ydkigome	527	10	infl	infl	NN
cord-264884-ydkigome	527	11	uenza	uenza	NNP
cord-264884-ydkigome	527	12	A	A	NNP
cord-264884-ydkigome	527	13	and	and	CC
cord-264884-ydkigome	527	14	measles	measles	NN
cord-264884-ydkigome	527	15	virus	virus	NN
cord-264884-ydkigome	527	16	,	,	,
cord-264884-ydkigome	527	17	both	both	CC
cord-264884-ydkigome	527	18	acute	acute	JJ
cord-264884-ydkigome	527	19	human	human	JJ
cord-264884-ydkigome	527	20	respiratory	respiratory	JJ
cord-264884-ydkigome	527	21	infections	infection	NNS
cord-264884-ydkigome	527	22	due	due	JJ
cord-264884-ydkigome	527	23	to	to	IN
cord-264884-ydkigome	527	24	membrane	membrane	NN
cord-264884-ydkigome	527	25	-	-	HYPH
cord-264884-ydkigome	527	26	bound	bind	VBN
cord-264884-ydkigome	527	27	negative	negative	JJ
cord-264884-ydkigome	527	28	-	-	HYPH
cord-264884-ydkigome	527	29	stranded	strand	VBN
cord-264884-ydkigome	527	30	RNA	RNA	NNP
cord-264884-ydkigome	527	31	viruses	virus	NNS
cord-264884-ydkigome	527	32	,	,	,
cord-264884-ydkigome	527	33	are	be	VBP
cord-264884-ydkigome	527	34	striking	strike	VBG
cord-264884-ydkigome	527	35	.	.	.
cord-264884-ydkigome	528	1	The	the	DT
cord-264884-ydkigome	528	2	reasons	reason	NNS
cord-264884-ydkigome	528	3	for	for	IN
cord-264884-ydkigome	528	4	the	the	DT
cord-264884-ydkigome	528	5	maintained	maintain	VBN
cord-264884-ydkigome	528	6	genetic	genetic	JJ
cord-264884-ydkigome	528	7	stability	stability	NN
cord-264884-ydkigome	528	8	of	of	IN
cord-264884-ydkigome	528	9	measles	measle	NNS
cord-264884-ydkigome	528	10	virus	virus	NN
cord-264884-ydkigome	528	11	remain	remain	VBP
cord-264884-ydkigome	528	12	poorly	poorly	RB
cord-264884-ydkigome	528	13	understood	understand	VBN
cord-264884-ydkigome	528	14	,	,	,
cord-264884-ydkigome	528	15	but	but	CC
cord-264884-ydkigome	528	16	may	may	MD
cord-264884-ydkigome	528	17	well	well	RB
cord-264884-ydkigome	528	18	involve	involve	VB
cord-264884-ydkigome	528	19	more	more	RBR
cord-264884-ydkigome	528	20	complex	complex	JJ
cord-264884-ydkigome	528	21	fi	fi	NN
cord-264884-ydkigome	528	22	tness	tness	NN
cord-264884-ydkigome	528	23	associated	associate	VBN
cord-264884-ydkigome	528	24	with	with	IN
cord-264884-ydkigome	528	25	systemic	systemic	JJ
cord-264884-ydkigome	528	26	infections	infection	NNS
cord-264884-ydkigome	528	27	.	.	.
cord-264884-ydkigome	529	1	Phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	529	2	methods	method	NNS
cord-264884-ydkigome	529	3	can	can	MD
cord-264884-ydkigome	529	4	also	also	RB
cord-264884-ydkigome	529	5	be	be	VB
cord-264884-ydkigome	529	6	highly	highly	RB
cord-264884-ydkigome	529	7	informative	informative	JJ
cord-264884-ydkigome	529	8	regarding	regard	VBG
cord-264884-ydkigome	529	9	the	the	DT
cord-264884-ydkigome	529	10	likely	likely	JJ
cord-264884-ydkigome	529	11	origins	origin	NNS
cord-264884-ydkigome	529	12	of	of	IN
cord-264884-ydkigome	529	13	viral	viral	JJ
cord-264884-ydkigome	529	14	lineages	lineage	NNS
cord-264884-ydkigome	529	15	and	and	CC
cord-264884-ydkigome	529	16	possible	possible	JJ
cord-264884-ydkigome	529	17	sources	source	NNS
cord-264884-ydkigome	529	18	of	of	IN
cord-264884-ydkigome	529	19	emergence	emergence	NN
cord-264884-ydkigome	529	20	.	.	.
cord-264884-ydkigome	530	1	For	for	IN
cord-264884-ydkigome	530	2	example	example	NN
cord-264884-ydkigome	530	3	,	,	,
cord-264884-ydkigome	530	4	the	the	DT
cord-264884-ydkigome	530	5	studies	study	NNS
cord-264884-ydkigome	530	6	of	of	IN
cord-264884-ydkigome	530	7	dengue	dengue	NN
cord-264884-ydkigome	530	8	virus	virus	NN
cord-264884-ydkigome	530	9	by	by	IN
cord-264884-ydkigome	530	10	Holmes	Holmes	NNP
cord-264884-ydkigome	530	11	and	and	CC
cord-264884-ydkigome	530	12	colleagues	colleague	NNS
cord-264884-ydkigome	530	13	suggest	suggest	VBP
cord-264884-ydkigome	530	14	that	that	IN
cord-264884-ydkigome	530	15	this	this	DT
cord-264884-ydkigome	530	16	virus	virus	NN
cord-264884-ydkigome	530	17	fi	fi	NN
cord-264884-ydkigome	530	18	rst	rst	NNP
cord-264884-ydkigome	530	19	entered	enter	VBD
cord-264884-ydkigome	530	20	its	-PRON-	PRP$
cord-264884-ydkigome	530	21	human	human	JJ
cord-264884-ydkigome	530	22	host	host	NN
cord-264884-ydkigome	530	23	about	about	IN
cord-264884-ydkigome	530	24	1000	1000	CD
cord-264884-ydkigome	530	25	years	year	NNS
cord-264884-ydkigome	530	26	ago	ago	RB
cord-264884-ydkigome	530	27	,	,	,
cord-264884-ydkigome	530	28	and	and	CC
cord-264884-ydkigome	530	29	that	that	DT
cord-264884-ydkigome	530	30	sylvatic	sylvatic	JJ
cord-264884-ydkigome	530	31	(	(	-LRB-
cord-264884-ydkigome	530	32	African	african	JJ
cord-264884-ydkigome	530	33	jungle	jungle	NN
cord-264884-ydkigome	530	34	)	)	-RRB-
cord-264884-ydkigome	530	35	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	530	36	infection	infection	NN
cord-264884-ydkigome	530	37	of	of	IN
cord-264884-ydkigome	530	38	primates	primate	NNS
cord-264884-ydkigome	530	39	may	may	MD
cord-264884-ydkigome	530	40	have	have	VB
cord-264884-ydkigome	530	41	provided	provide	VBN
cord-264884-ydkigome	530	42	the	the	DT
cord-264884-ydkigome	530	43	origin	origin	NN
cord-264884-ydkigome	530	44	of	of	IN
cord-264884-ydkigome	530	45	this	this	DT
cord-264884-ydkigome	530	46	virus	virus	NN
cord-264884-ydkigome	530	47	that	that	WDT
cord-264884-ydkigome	530	48	later	later	RB
cord-264884-ydkigome	530	49	became	become	VBD
cord-264884-ydkigome	530	50	a	a	DT
cord-264884-ydkigome	530	51	human	human	JJ
cord-264884-ydkigome	530	52	pathogen	pathogen	NN
cord-264884-ydkigome	530	53	(	(	-LRB-
cord-264884-ydkigome	530	54	Holmes	Holmes	NNP
cord-264884-ydkigome	530	55	and	and	CC
cord-264884-ydkigome	530	56	Twiddy	Twiddy	NNP
cord-264884-ydkigome	530	57	,	,	,
cord-264884-ydkigome	530	58	2003	2003	CD
cord-264884-ydkigome	530	59	;	;	:
cord-264884-ydkigome	530	60	Holmes	Holmes	NNP
cord-264884-ydkigome	530	61	,	,	,
cord-264884-ydkigome	530	62	2006	2006	CD
cord-264884-ydkigome	530	63	)	)	-RRB-
cord-264884-ydkigome	530	64	.	.	.
cord-264884-ydkigome	531	1	Such	such	JJ
cord-264884-ydkigome	531	2	insight	insight	NN
cord-264884-ydkigome	531	3	provides	provide	VBZ
cord-264884-ydkigome	531	4	valuable	valuable	JJ
cord-264884-ydkigome	531	5	clues	clue	NNS
cord-264884-ydkigome	531	6	concerning	concern	VBG
cord-264884-ydkigome	531	7	the	the	DT
cord-264884-ydkigome	531	8	likely	likely	JJ
cord-264884-ydkigome	531	9	selective	selective	JJ
cord-264884-ydkigome	531	10	pressures	pressure	NNS
cord-264884-ydkigome	531	11	that	that	WDT
cord-264884-ydkigome	531	12	may	may	MD
cord-264884-ydkigome	531	13	lead	lead	VB
cord-264884-ydkigome	531	14	to	to	IN
cord-264884-ydkigome	531	15	the	the	DT
cord-264884-ydkigome	531	16	emergence	emergence	NN
cord-264884-ydkigome	531	17	of	of	IN
cord-264884-ydkigome	531	18	dengue	dengue	NN
cord-264884-ydkigome	531	19	virus	virus	NN
cord-264884-ydkigome	531	20	.	.	.
cord-264884-ydkigome	532	1	Phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	532	2	methods	method	NNS
cord-264884-ydkigome	532	3	are	be	VBP
cord-264884-ydkigome	532	4	also	also	RB
cord-264884-ydkigome	532	5	highly	highly	RB
cord-264884-ydkigome	532	6	informative	informative	JJ
cord-264884-ydkigome	532	7	regarding	regard	VBG
cord-264884-ydkigome	532	8	classifi	classifi	NNP
cord-264884-ydkigome	532	9	cation	cation	NN
cord-264884-ydkigome	532	10	and	and	CC
cord-264884-ydkigome	532	11	taxonomy	taxonomy	NN
cord-264884-ydkigome	532	12	relationships	relationship	NNS
cord-264884-ydkigome	532	13	and	and	CC
cord-264884-ydkigome	532	14	have	have	VBP
cord-264884-ydkigome	532	15	allowed	allow	VBN
cord-264884-ydkigome	532	16	us	-PRON-	PRP
cord-264884-ydkigome	532	17	to	to	TO
cord-264884-ydkigome	532	18	understand	understand	VB
cord-264884-ydkigome	532	19	viral	viral	JJ
cord-264884-ydkigome	532	20	relationships	relationship	NNS
cord-264884-ydkigome	532	21	across	across	IN
cord-264884-ydkigome	532	22	broad	broad	JJ
cord-264884-ydkigome	532	23	species	specie	NNS
cord-264884-ydkigome	532	24	defi	defi	NNP
cord-264884-ydkigome	532	25	nitions	nitions	NNP
cord-264884-ydkigome	532	26	(	(	-LRB-
cord-264884-ydkigome	532	27	Zanotto	Zanotto	NNP
cord-264884-ydkigome	532	28	et	et	NNP
cord-264884-ydkigome	532	29	al	al	NNP
cord-264884-ydkigome	532	30	.	.	NNP
cord-264884-ydkigome	532	31	,	,	,
cord-264884-ydkigome	532	32	1996	1996	CD
cord-264884-ydkigome	532	33	)	)	-RRB-
cord-264884-ydkigome	532	34	.	.	.
cord-264884-ydkigome	533	1	However	however	RB
cord-264884-ydkigome	533	2	,	,	,
cord-264884-ydkigome	533	3	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	533	4	approaches	approach	NNS
cord-264884-ydkigome	533	5	necessarily	necessarily	RB
cord-264884-ydkigome	533	6	assume	assume	VBP
cord-264884-ydkigome	533	7	the	the	DT
cord-264884-ydkigome	533	8	master	master	NN
cord-264884-ydkigome	533	9	template	template	NN
cord-264884-ydkigome	533	10	is	be	VBZ
cord-264884-ydkigome	533	11	the	the	DT
cord-264884-ydkigome	533	12	fi	fi	NNP
cord-264884-ydkigome	533	13	ttest	ttest	NN
cord-264884-ydkigome	533	14	type	type	NN
cord-264884-ydkigome	533	15	and	and	CC
cord-264884-ydkigome	533	16	that	that	IN
cord-264884-ydkigome	533	17	mutations	mutation	NNS
cord-264884-ydkigome	533	18	or	or	CC
cord-264884-ydkigome	533	19	variants	variant	NNS
cord-264884-ydkigome	533	20	in	in	IN
cord-264884-ydkigome	533	21	the	the	DT
cord-264884-ydkigome	533	22	RNA	RNA	NNP
cord-264884-ydkigome	533	23	populations	population	NNS
cord-264884-ydkigome	533	24	are	be	VBP
cord-264884-ydkigome	533	25	a	a	DT
cord-264884-ydkigome	533	26	source	source	NN
cord-264884-ydkigome	533	27	of	of	IN
cord-264884-ydkigome	533	28	genetic	genetic	JJ
cord-264884-ydkigome	533	29	load	load	NN
cord-264884-ydkigome	533	30	that	that	WDT
cord-264884-ydkigome	533	31	are	be	VBP
cord-264884-ydkigome	533	32	deleterious	deleterious	JJ
cord-264884-ydkigome	533	33	and	and	CC
cord-264884-ydkigome	533	34	limiting	limit	VBG
cord-264884-ydkigome	533	35	to	to	IN
cord-264884-ydkigome	533	36	virus	virus	NN
cord-264884-ydkigome	533	37	adaptation	adaptation	NN
cord-264884-ydkigome	533	38	(	(	-LRB-
cord-264884-ydkigome	533	39	Pybus	Pybus	NNP
cord-264884-ydkigome	533	40	et	et	NNP
cord-264884-ydkigome	533	41	al	al	NNP
cord-264884-ydkigome	533	42	.	.	NNP
cord-264884-ydkigome	533	43	,	,	,
cord-264884-ydkigome	533	44	2007	2007	CD
cord-264884-ydkigome	533	45	)	)	-RRB-
cord-264884-ydkigome	533	46	.	.	.
cord-264884-ydkigome	534	1	Such	such	JJ
cord-264884-ydkigome	534	2	variation	variation	NN
cord-264884-ydkigome	534	3	is	be	VBZ
cord-264884-ydkigome	534	4	mostly	mostly	RB
cord-264884-ydkigome	534	5	due	due	JJ
cord-264884-ydkigome	534	6	to	to	IN
cord-264884-ydkigome	534	7	"	"	``
cord-264884-ydkigome	534	8	unfi	unfi	NNP
cord-264884-ydkigome	534	9	t	t	NNP
cord-264884-ydkigome	534	10	"	"	''
cord-264884-ydkigome	534	11	mutations	mutation	NNS
cord-264884-ydkigome	534	12	,	,	,
cord-264884-ydkigome	534	13	which	which	WDT
cord-264884-ydkigome	534	14	indicates	indicate	VBZ
cord-264884-ydkigome	534	15	that	that	IN
cord-264884-ydkigome	534	16	a	a	DT
cord-264884-ydkigome	534	17	viral	viral	JJ
cord-264884-ydkigome	534	18	cloud	cloud	NN
cord-264884-ydkigome	534	19	is	be	VBZ
cord-264884-ydkigome	534	20	mostly	mostly	RB
cord-264884-ydkigome	534	21	and	and	CC
cord-264884-ydkigome	534	22	unfi	unfi	NNP
cord-264884-ydkigome	534	23	t	t	NNP
cord-264884-ydkigome	534	24	consortia	consortia	NNP
cord-264884-ydkigome	534	25	.	.	.
cord-264884-ydkigome	535	1	It	-PRON-	PRP
cord-264884-ydkigome	535	2	would	would	MD
cord-264884-ydkigome	535	3	seem	seem	VB
cord-264884-ydkigome	535	4	that	that	IN
cord-264884-ydkigome	535	5	such	such	JJ
cord-264884-ydkigome	535	6	conclusions	conclusion	NNS
cord-264884-ydkigome	535	7	go	go	VBP
cord-264884-ydkigome	535	8	against	against	IN
cord-264884-ydkigome	535	9	the	the	DT
cord-264884-ydkigome	535	10	concept	concept	NN
cord-264884-ydkigome	535	11	of	of	IN
cord-264884-ydkigome	535	12	quasispecies	quasispecie	NNS
cord-264884-ydkigome	535	13	as	as	IN
cord-264884-ydkigome	535	14	being	be	VBG
cord-264884-ydkigome	535	15	fi	fi	NNP
cord-264884-ydkigome	535	16	t	t	NN
cord-264884-ydkigome	535	17	per	per	FW
cord-264884-ydkigome	535	18	se	se	FW
cord-264884-ydkigome	535	19	as	as	IN
cord-264884-ydkigome	535	20	described	describe	VBN
cord-264884-ydkigome	535	21	above	above	RB
cord-264884-ydkigome	535	22	.	.	.
cord-264884-ydkigome	536	1	In	in	IN
cord-264884-ydkigome	536	2	this	this	DT
cord-264884-ydkigome	536	3	consideration	consideration	NN
cord-264884-ydkigome	536	4	we	-PRON-	PRP
cord-264884-ydkigome	536	5	see	see	VBP
cord-264884-ydkigome	536	6	a	a	DT
cord-264884-ydkigome	536	7	major	major	JJ
cord-264884-ydkigome	536	8	weakness	weakness	NN
cord-264884-ydkigome	536	9	of	of	IN
cord-264884-ydkigome	536	10	extant	extant	JJ
cord-264884-ydkigome	536	11	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	536	12	methods	method	NNS
cord-264884-ydkigome	536	13	.	.	.
cord-264884-ydkigome	537	1	They	-PRON-	PRP
cord-264884-ydkigome	537	2	were	be	VBD
cord-264884-ydkigome	537	3	not	not	RB
cord-264884-ydkigome	537	4	developed	develop	VBN
cord-264884-ydkigome	537	5	to	to	TO
cord-264884-ydkigome	537	6	access	access	VB
cord-264884-ydkigome	537	7	the	the	DT
cord-264884-ydkigome	537	8	evolutionary	evolutionary	JJ
cord-264884-ydkigome	537	9	relationship	relationship	NN
cord-264884-ydkigome	537	10	and	and	CC
cord-264884-ydkigome	537	11	fi	fi	NN
cord-264884-ydkigome	537	12	tness	tness	NN
cord-264884-ydkigome	537	13	of	of	IN
cord-264884-ydkigome	537	14	interacting	interact	VBG
cord-264884-ydkigome	537	15	mixtures	mixture	NNS
cord-264884-ydkigome	537	16	.	.	.
cord-264884-ydkigome	538	1	Nor	nor	CC
cord-264884-ydkigome	538	2	were	be	VBD
cord-264884-ydkigome	538	3	they	-PRON-	PRP
cord-264884-ydkigome	538	4	designed	design	VBN
cord-264884-ydkigome	538	5	to	to	TO
cord-264884-ydkigome	538	6	follow	follow	VB
cord-264884-ydkigome	538	7	the	the	DT
cord-264884-ydkigome	538	8	evolution	evolution	NN
cord-264884-ydkigome	538	9	of	of	IN
cord-264884-ydkigome	538	10	systems	system	NNS
cord-264884-ydkigome	538	11	with	with	IN
cord-264884-ydkigome	538	12	high	high	JJ
cord-264884-ydkigome	538	13	rates	rate	NNS
cord-264884-ydkigome	538	14	of	of	IN
cord-264884-ydkigome	538	15	recombination	recombination	NN
cord-264884-ydkigome	538	16	between	between	IN
cord-264884-ydkigome	538	17	numerous	numerous	JJ
cord-264884-ydkigome	538	18	parental	parental	JJ
cord-264884-ydkigome	538	19	templates	template	NNS
cord-264884-ydkigome	538	20	.	.	.
cord-264884-ydkigome	539	1	We	-PRON-	PRP
cord-264884-ydkigome	539	2	currently	currently	RB
cord-264884-ydkigome	539	3	lack	lack	VBP
cord-264884-ydkigome	539	4	the	the	DT
cord-264884-ydkigome	539	5	analytical	analytical	JJ
cord-264884-ydkigome	539	6	tools	tool	NNS
cord-264884-ydkigome	539	7	for	for	IN
cord-264884-ydkigome	539	8	such	such	PDT
cord-264884-ydkigome	539	9	a	a	DT
cord-264884-ydkigome	539	10	population	population	NN
cord-264884-ydkigome	539	11	analysis	analysis	NN
cord-264884-ydkigome	539	12	.	.	.
cord-264884-ydkigome	540	1	Without	without	IN
cord-264884-ydkigome	540	2	such	such	JJ
cord-264884-ydkigome	540	3	tools	tool	NNS
cord-264884-ydkigome	540	4	,	,	,
cord-264884-ydkigome	540	5	however	however	RB
cord-264884-ydkigome	540	6	,	,	,
cord-264884-ydkigome	540	7	it	-PRON-	PRP
cord-264884-ydkigome	540	8	seems	seem	VBZ
cord-264884-ydkigome	540	9	we	-PRON-	PRP
cord-264884-ydkigome	540	10	can	can	MD
cord-264884-ydkigome	540	11	only	only	RB
cord-264884-ydkigome	540	12	evaluate	evaluate	VB
cord-264884-ydkigome	540	13	those	those	DT
cord-264884-ydkigome	540	14	parameters	parameter	NNS
cord-264884-ydkigome	540	15	we	-PRON-	PRP
cord-264884-ydkigome	540	16	can	can	MD
cord-264884-ydkigome	540	17	defi	defi	VB
cord-264884-ydkigome	540	18	ne	ne	NNP
cord-264884-ydkigome	540	19	and	and	CC
cord-264884-ydkigome	540	20	will	will	MD
cord-264884-ydkigome	540	21	remain	remain	VB
cord-264884-ydkigome	540	22	confused	confused	JJ
cord-264884-ydkigome	540	23	by	by	IN
cord-264884-ydkigome	540	24	those	those	DT
cord-264884-ydkigome	540	25	we	-PRON-	PRP
cord-264884-ydkigome	540	26	can	can	MD
cord-264884-ydkigome	540	27	not	not	RB
cord-264884-ydkigome	540	28	.	.	.
cord-264884-ydkigome	541	1	Evolution	evolution	NN
cord-264884-ydkigome	541	2	of	of	IN
cord-264884-ydkigome	541	3	a	a	DT
cord-264884-ydkigome	541	4	consortia	consortia	NN
cord-264884-ydkigome	541	5	thus	thus	RB
cord-264884-ydkigome	541	6	provides	provide	VBZ
cord-264884-ydkigome	541	7	a	a	DT
cord-264884-ydkigome	541	8	new	new	JJ
cord-264884-ydkigome	541	9	directions	direction	NNS
cord-264884-ydkigome	541	10	for	for	IN
cord-264884-ydkigome	541	11	theoretical	theoretical	JJ
cord-264884-ydkigome	541	12	and	and	CC
cord-264884-ydkigome	541	13	laboratory	laboratory	NN
cord-264884-ydkigome	541	14	research	research	NN
cord-264884-ydkigome	541	15	.	.	.
cord-264884-ydkigome	542	1	We	-PRON-	PRP
cord-264884-ydkigome	542	2	should	should	MD
cord-264884-ydkigome	542	3	seek	seek	VB
cord-264884-ydkigome	542	4	to	to	TO
cord-264884-ydkigome	542	5	investigate	investigate	VB
cord-264884-ydkigome	542	6	the	the	DT
cord-264884-ydkigome	542	7	mixture	mixture	NN
cord-264884-ydkigome	542	8	,	,	,
cord-264884-ydkigome	542	9	not	not	RB
cord-264884-ydkigome	542	10	just	just	RB
cord-264884-ydkigome	542	11	its	-PRON-	PRP$
cord-264884-ydkigome	542	12	average	average	NN
cord-264884-ydkigome	542	13	.	.	.
cord-264884-ydkigome	543	1	Another	another	DT
cord-264884-ydkigome	543	2	major	major	JJ
cord-264884-ydkigome	543	3	virus	virus	NN
cord-264884-ydkigome	543	4	-	-	HYPH
cord-264884-ydkigome	543	5	host	host	NN
cord-264884-ydkigome	543	6	system	system	NN
cord-264884-ydkigome	543	7	that	that	WDT
cord-264884-ydkigome	543	8	has	have	VBZ
cord-264884-ydkigome	543	9	been	be	VBN
cord-264884-ydkigome	543	10	highly	highly	RB
cord-264884-ydkigome	543	11	studied	study	VBN
cord-264884-ydkigome	543	12	is	be	VBZ
cord-264884-ydkigome	543	13	the	the	DT
cord-264884-ydkigome	543	14	viruses	virus	NNS
cord-264884-ydkigome	543	15	of	of	IN
cord-264884-ydkigome	543	16	agricultural	agricultural	JJ
cord-264884-ydkigome	543	17	plants	plant	NNS
cord-264884-ydkigome	543	18	.	.	.
cord-264884-ydkigome	544	1	Our	-PRON-	PRP$
cord-264884-ydkigome	544	2	understanding	understanding	NN
cord-264884-ydkigome	544	3	of	of	IN
cord-264884-ydkigome	544	4	plant	plant	NN
cord-264884-ydkigome	544	5	viruses	virus	NNS
cord-264884-ydkigome	544	6	has	have	VBZ
cord-264884-ydkigome	544	7	also	also	RB
cord-264884-ydkigome	544	8	been	be	VBN
cord-264884-ydkigome	544	9	highly	highly	RB
cord-264884-ydkigome	544	10	infl	infl	NN
cord-264884-ydkigome	544	11	uenced	uence	VBN
cord-264884-ydkigome	544	12	by	by	IN
cord-264884-ydkigome	544	13	disease	disease	NN
cord-264884-ydkigome	544	14	associated	associate	VBN
cord-264884-ydkigome	544	15	with	with	IN
cord-264884-ydkigome	544	16	agricultural	agricultural	JJ
cord-264884-ydkigome	544	17	domestic	domestic	JJ
cord-264884-ydkigome	544	18	species	specie	NNS
cord-264884-ydkigome	544	19	,	,	,
cord-264884-ydkigome	544	20	thus	thus	RB
cord-264884-ydkigome	544	21	natural	natural	JJ
cord-264884-ydkigome	544	22	virus	virus	NN
cord-264884-ydkigome	544	23	-	-	HYPH
cord-264884-ydkigome	544	24	plant	plant	NN
cord-264884-ydkigome	544	25	relationships	relationship	NNS
cord-264884-ydkigome	544	26	are	be	VBP
cord-264884-ydkigome	544	27	much	much	RB
cord-264884-ydkigome	544	28	less	less	RBR
cord-264884-ydkigome	544	29	understood	understand	VBN
cord-264884-ydkigome	544	30	,	,	,
cord-264884-ydkigome	544	31	although	although	IN
cord-264884-ydkigome	544	32	some	some	DT
cord-264884-ydkigome	544	33	recent	recent	JJ
cord-264884-ydkigome	544	34	fi	fi	NNP
cord-264884-ydkigome	544	35	eld	eld	NNP
cord-264884-ydkigome	544	36	studies	study	NNS
cord-264884-ydkigome	544	37	are	be	VBP
cord-264884-ydkigome	544	38	starting	start	VBG
cord-264884-ydkigome	544	39	to	to	TO
cord-264884-ydkigome	544	40	change	change	VB
cord-264884-ydkigome	544	41	this	this	DT
cord-264884-ydkigome	544	42	situation	situation	NN
cord-264884-ydkigome	544	43	(	(	-LRB-
cord-264884-ydkigome	544	44	see	see	VB
cord-264884-ydkigome	544	45	Chapter	chapter	NN
cord-264884-ydkigome	544	46	12	12	CD
cord-264884-ydkigome	544	47	)	)	-RRB-
cord-264884-ydkigome	544	48	.	.	.
cord-264884-ydkigome	545	1	We	-PRON-	PRP
cord-264884-ydkigome	545	2	currently	currently	RB
cord-264884-ydkigome	545	3	have	have	VBP
cord-264884-ydkigome	545	4	a	a	DT
cord-264884-ydkigome	545	5	rather	rather	RB
cord-264884-ydkigome	545	6	uneven	uneven	JJ
cord-264884-ydkigome	545	7	understanding	understanding	NN
cord-264884-ydkigome	545	8	of	of	IN
cord-264884-ydkigome	545	9	broader	broad	JJR
cord-264884-ydkigome	545	10	virus	virus	NN
cord-264884-ydkigome	545	11	-	-	HYPH
cord-264884-ydkigome	545	12	host	host	NN
cord-264884-ydkigome	545	13	relationships	relationship	NNS
cord-264884-ydkigome	545	14	and	and	CC
cord-264884-ydkigome	545	15	evolution	evolution	NN
cord-264884-ydkigome	545	16	in	in	IN
cord-264884-ydkigome	545	17	plants	plant	NNS
cord-264884-ydkigome	545	18	.	.	.
cord-264884-ydkigome	546	1	For	for	IN
cord-264884-ydkigome	546	2	example	example	NN
cord-264884-ydkigome	546	3	,	,	,
cord-264884-ydkigome	546	4	viruses	virus	NNS
cord-264884-ydkigome	546	5	of	of	IN
cord-264884-ydkigome	546	6	the	the	DT
cord-264884-ydkigome	546	7	more	more	JJR
cord-264884-ydkigome	546	8	ancient	ancient	JJ
cord-264884-ydkigome	546	9	ferns	fern	NNS
cord-264884-ydkigome	546	10	,	,	,
cord-264884-ydkigome	546	11	if	if	IN
cord-264884-ydkigome	546	12	they	-PRON-	PRP
cord-264884-ydkigome	546	13	exist	exist	VBP
cord-264884-ydkigome	546	14	,	,	,
cord-264884-ydkigome	546	15	are	be	VBP
cord-264884-ydkigome	546	16	essentially	essentially	RB
cord-264884-ydkigome	546	17	unknown	unknown	JJ
cord-264884-ydkigome	546	18	.	.	.
cord-264884-ydkigome	547	1	The	the	DT
cord-264884-ydkigome	547	2	prevalence	prevalence	NN
cord-264884-ydkigome	547	3	and	and	CC
cord-264884-ydkigome	547	4	diversity	diversity	NN
cord-264884-ydkigome	547	5	of	of	IN
cord-264884-ydkigome	547	6	positivestranded	positivestranded	NNP
cord-264884-ydkigome	547	7	RNA	RNA	NNP
cord-264884-ydkigome	547	8	viruses	virus	NNS
cord-264884-ydkigome	547	9	in	in	IN
cord-264884-ydkigome	547	10	plants	plant	NNS
cord-264884-ydkigome	547	11	is	be	VBZ
cord-264884-ydkigome	547	12	striking	strike	VBG
cord-264884-ydkigome	547	13	.	.	.
cord-264884-ydkigome	548	1	In	in	IN
cord-264884-ydkigome	548	2	addition	addition	NN
cord-264884-ydkigome	548	3	,	,	,
cord-264884-ydkigome	548	4	we	-PRON-	PRP
cord-264884-ydkigome	548	5	are	be	VBP
cord-264884-ydkigome	548	6	starting	start	VBG
cord-264884-ydkigome	548	7	to	to	TO
cord-264884-ydkigome	548	8	appreciate	appreciate	VB
cord-264884-ydkigome	548	9	that	that	IN
cord-264884-ydkigome	548	10	virus	virus	NN
cord-264884-ydkigome	548	11	-	-	HYPH
cord-264884-ydkigome	548	12	virus	virus	NN
cord-264884-ydkigome	548	13	interactions	interaction	NNS
cord-264884-ydkigome	548	14	are	be	VBP
cord-264884-ydkigome	548	15	also	also	RB
cord-264884-ydkigome	548	16	frequently	frequently	RB
cord-264884-ydkigome	548	17	involved	involve	VBN
cord-264884-ydkigome	548	18	,	,	,
cord-264884-ydkigome	548	19	although	although	IN
cord-264884-ydkigome	548	20	this	this	DT
cord-264884-ydkigome	548	21	issue	issue	NN
cord-264884-ydkigome	548	22	remains	remain	VBZ
cord-264884-ydkigome	548	23	poorly	poorly	RB
cord-264884-ydkigome	548	24	studied	study	VBN
cord-264884-ydkigome	548	25	.	.	.
cord-264884-ydkigome	549	1	One	one	CD
cord-264884-ydkigome	549	2	well	well	RB
cord-264884-ydkigome	549	3	-	-	HYPH
cord-264884-ydkigome	549	4	studied	study	VBN
cord-264884-ydkigome	549	5	family	family	NN
cord-264884-ydkigome	549	6	of	of	IN
cord-264884-ydkigome	549	7	plant	plant	NN
cord-264884-ydkigome	549	8	virus	virus	NN
cord-264884-ydkigome	549	9	are	be	VBP
cord-264884-ydkigome	549	10	the	the	DT
cord-264884-ydkigome	549	11	tobamoviruses	tobamoviruse	NNS
cord-264884-ydkigome	549	12	of	of	IN
cord-264884-ydkigome	549	13	angiosperms	angiosperm	NNS
cord-264884-ydkigome	549	14	(	(	-LRB-
cord-264884-ydkigome	549	15	see	see	VB
cord-264884-ydkigome	549	16	Chapter	chapter	NN
cord-264884-ydkigome	549	17	11	11	CD
cord-264884-ydkigome	549	18	;	;	:
cord-264884-ydkigome	549	19	Gibbs	Gibbs	NNP
cord-264884-ydkigome	549	20	,	,	,
cord-264884-ydkigome	549	21	1999	1999	CD
cord-264884-ydkigome	549	22	)	)	-RRB-
cord-264884-ydkigome	549	23	.	.	.
cord-264884-ydkigome	550	1	Progenitors	progenitor	NNS
cord-264884-ydkigome	550	2	of	of	IN
cord-264884-ydkigome	550	3	this	this	DT
cord-264884-ydkigome	550	4	virus	virus	NN
cord-264884-ydkigome	550	5	family	family	NN
cord-264884-ydkigome	550	6	appear	appear	VBP
cord-264884-ydkigome	550	7	to	to	TO
cord-264884-ydkigome	550	8	also	also	RB
cord-264884-ydkigome	550	9	be	be	VB
cord-264884-ydkigome	550	10	found	find	VBN
cord-264884-ydkigome	550	11	in	in	IN
cord-264884-ydkigome	550	12	algae	algae	NN
cord-264884-ydkigome	550	13	and	and	CC
cord-264884-ydkigome	550	14	fungi	fungus	NNS
cord-264884-ydkigome	550	15	consistent	consistent	JJ
cord-264884-ydkigome	550	16	with	with	IN
cord-264884-ydkigome	550	17	a	a	DT
cord-264884-ydkigome	550	18	very	very	RB
cord-264884-ydkigome	550	19	long	long	JJ
cord-264884-ydkigome	550	20	evolutionary	evolutionary	JJ
cord-264884-ydkigome	550	21	history	history	NN
cord-264884-ydkigome	550	22	.	.	.
cord-264884-ydkigome	551	1	Both	both	DT
cord-264884-ydkigome	551	2	high	high	JJ
cord-264884-ydkigome	551	3	transmission	transmission	NN
cord-264884-ydkigome	551	4	between	between	IN
cord-264884-ydkigome	551	5	host	host	NN
cord-264884-ydkigome	551	6	and	and	CC
cord-264884-ydkigome	551	7	virus	virus	NN
cord-264884-ydkigome	551	8	-	-	HYPH
cord-264884-ydkigome	551	9	host	host	NN
cord-264884-ydkigome	551	10	congruence	congruence	NN
cord-264884-ydkigome	551	11	are	be	VBP
cord-264884-ydkigome	551	12	observed	observe	VBN
cord-264884-ydkigome	551	13	with	with	IN
cord-264884-ydkigome	551	14	these	these	DT
cord-264884-ydkigome	551	15	viruses	virus	NNS
cord-264884-ydkigome	551	16	.	.	.
cord-264884-ydkigome	552	1	Virus	virus	NN
cord-264884-ydkigome	552	2	-	-	HYPH
cord-264884-ydkigome	552	3	virus	virus	NN
cord-264884-ydkigome	552	4	interactions	interaction	NNS
cord-264884-ydkigome	552	5	also	also	RB
cord-264884-ydkigome	552	6	seem	seem	VBP
cord-264884-ydkigome	552	7	to	to	TO
cord-264884-ydkigome	552	8	be	be	VB
cord-264884-ydkigome	552	9	important	important	JJ
cord-264884-ydkigome	552	10	.	.	.
cord-264884-ydkigome	553	1	For	for	IN
cord-264884-ydkigome	553	2	example	example	NN
cord-264884-ydkigome	553	3	,	,	,
cord-264884-ydkigome	553	4	tobacco	tobacco	NN
cord-264884-ydkigome	553	5	mosaic	mosaic	NN
cord-264884-ydkigome	553	6	virus	virus	NN
cord-264884-ydkigome	553	7	(	(	-LRB-
cord-264884-ydkigome	553	8	TMV	TMV	NNP
cord-264884-ydkigome	553	9	)	)	-RRB-
cord-264884-ydkigome	553	10	and	and	CC
cord-264884-ydkigome	553	11	tomato	tomato	NN
cord-264884-ydkigome	553	12	golden	golden	JJ
cord-264884-ydkigome	553	13	mosaic	mosaic	JJ
cord-264884-ydkigome	553	14	virus	virus	NN
cord-264884-ydkigome	553	15	(	(	-LRB-
cord-264884-ydkigome	553	16	TMGV	TMGV	NNP
cord-264884-ydkigome	553	17	)	)	-RRB-
cord-264884-ydkigome	553	18	appear	appear	VBP
cord-264884-ydkigome	553	19	to	to	TO
cord-264884-ydkigome	553	20	have	have	VB
cord-264884-ydkigome	553	21	shown	show	VBN
cord-264884-ydkigome	553	22	interactions	interaction	NNS
cord-264884-ydkigome	553	23	in	in	IN
cord-264884-ydkigome	553	24	Australia	Australia	NNP
cord-264884-ydkigome	553	25	which	which	WDT
cord-264884-ydkigome	553	26	have	have	VBP
cord-264884-ydkigome	553	27	apparently	apparently	RB
cord-264884-ydkigome	553	28	led	lead	VBN
cord-264884-ydkigome	553	29	to	to	IN
cord-264884-ydkigome	553	30	the	the	DT
cord-264884-ydkigome	553	31	extinction	extinction	NN
cord-264884-ydkigome	553	32	of	of	IN
cord-264884-ydkigome	553	33	TMV	TMV	NNP
cord-264884-ydkigome	553	34	,	,	,
cord-264884-ydkigome	553	35	but	but	CC
cord-264884-ydkigome	553	36	the	the	DT
cord-264884-ydkigome	553	37	retention	retention	NN
cord-264884-ydkigome	553	38	of	of	IN
cord-264884-ydkigome	553	39	TMGV	TMGV	NNP
cord-264884-ydkigome	553	40	with	with	IN
cord-264884-ydkigome	553	41	no	no	DT
cord-264884-ydkigome	553	42	increase	increase	NN
cord-264884-ydkigome	553	43	in	in	IN
cord-264884-ydkigome	553	44	genetic	genetic	JJ
cord-264884-ydkigome	553	45	diversity	diversity	NN
cord-264884-ydkigome	554	1	(	(	-LRB-
cord-264884-ydkigome	554	2	Fraile	Fraile	NNP
cord-264884-ydkigome	554	3	et	et	FW
cord-264884-ydkigome	554	4	al	al	NNP
cord-264884-ydkigome	554	5	.	.	NNP
cord-264884-ydkigome	554	6	,	,	,
cord-264884-ydkigome	554	7	1997	1997	CD
cord-264884-ydkigome	554	8	)	)	-RRB-
cord-264884-ydkigome	554	9	.	.	.
cord-264884-ydkigome	555	1	Plant	plant	NN
cord-264884-ydkigome	555	2	viruses	virus	NNS
cord-264884-ydkigome	555	3	have	have	VBP
cord-264884-ydkigome	555	4	also	also	RB
cord-264884-ydkigome	555	5	been	be	VBN
cord-264884-ydkigome	555	6	seen	see	VBN
cord-264884-ydkigome	555	7	as	as	IN
cord-264884-ydkigome	555	8	quasispecies	quasispecie	NNS
cord-264884-ydkigome	555	9	in	in	IN
cord-264884-ydkigome	555	10	some	some	DT
cord-264884-ydkigome	555	11	but	but	CC
cord-264884-ydkigome	555	12	not	not	RB
cord-264884-ydkigome	555	13	all	all	DT
cord-264884-ydkigome	555	14	settings	setting	NNS
cord-264884-ydkigome	555	15	(	(	-LRB-
cord-264884-ydkigome	555	16	see	see	VB
cord-264884-ydkigome	555	17	Chapter	chapter	NN
cord-264884-ydkigome	555	18	12	12	CD
cord-264884-ydkigome	555	19	;	;	.
cord-264884-ydkigome	556	1	Roossinck	Roossinck	NNP
cord-264884-ydkigome	556	2	,	,	,
cord-264884-ydkigome	556	3	2003	2003	CD
cord-264884-ydkigome	556	4	;	;	:
cord-264884-ydkigome	556	5	Roossinck	Roossinck	NNP
cord-264884-ydkigome	556	6	and	and	CC
cord-264884-ydkigome	556	7	Schneider	Schneider	NNP
cord-264884-ydkigome	556	8	,	,	,
cord-264884-ydkigome	556	9	2006	2006	CD
cord-264884-ydkigome	556	10	)	)	-RRB-
cord-264884-ydkigome	556	11	.	.	.
cord-264884-ydkigome	557	1	Besides	besides	IN
cord-264884-ydkigome	557	2	the	the	DT
cord-264884-ydkigome	557	3	interactions	interaction	NNS
cord-264884-ydkigome	557	4	expected	expect	VBN
cord-264884-ydkigome	557	5	for	for	IN
cord-264884-ydkigome	557	6	typical	typical	JJ
cord-264884-ydkigome	557	7	viral	viral	JJ
cord-264884-ydkigome	557	8	quasispecies	quasispecie	NNS
cord-264884-ydkigome	557	9	,	,	,
cord-264884-ydkigome	557	10	plants	plant	NNS
cord-264884-ydkigome	557	11	often	often	RB
cord-264884-ydkigome	557	12	show	show	VBP
cord-264884-ydkigome	557	13	evidence	evidence	NN
cord-264884-ydkigome	557	14	of	of	IN
cord-264884-ydkigome	557	15	more	more	RBR
cord-264884-ydkigome	557	16	extensive	extensive	JJ
cord-264884-ydkigome	557	17	mixed	mixed	JJ
cord-264884-ydkigome	557	18	virus	virus	NN
cord-264884-ydkigome	557	19	infections	infection	NNS
cord-264884-ydkigome	557	20	.	.	.
cord-264884-ydkigome	558	1	There	there	EX
cord-264884-ydkigome	558	2	are	be	VBP
cord-264884-ydkigome	558	3	,	,	,
cord-264884-ydkigome	558	4	for	for	IN
cord-264884-ydkigome	558	5	instance	instance	NN
cord-264884-ydkigome	558	6	,	,	,
cord-264884-ydkigome	558	7	many	many	JJ
cord-264884-ydkigome	558	8	examples	example	NNS
cord-264884-ydkigome	558	9	of	of	IN
cord-264884-ydkigome	558	10	satellite	satellite	NN
cord-264884-ydkigome	558	11	viruses	virus	NNS
cord-264884-ydkigome	558	12	that	that	WDT
cord-264884-ydkigome	558	13	must	must	MD
cord-264884-ydkigome	558	14	necessarily	necessarily	RB
cord-264884-ydkigome	558	15	interact	interact	VB
cord-264884-ydkigome	558	16	with	with	IN
cord-264884-ydkigome	558	17	other	other	JJ
cord-264884-ydkigome	558	18	RNA	RNA	NNP
cord-264884-ydkigome	558	19	viruses	virus	NNS
cord-264884-ydkigome	558	20	of	of	IN
cord-264884-ydkigome	558	21	plants	plant	NNS
cord-264884-ydkigome	558	22	.	.	.
cord-264884-ydkigome	559	1	It	-PRON-	PRP
cord-264884-ydkigome	559	2	is	be	VBZ
cord-264884-ydkigome	559	3	also	also	RB
cord-264884-ydkigome	559	4	clear	clear	JJ
cord-264884-ydkigome	559	5	that	that	IN
cord-264884-ydkigome	559	6	the	the	DT
cord-264884-ydkigome	559	7	subviral	subviral	JJ
cord-264884-ydkigome	559	8	elements	element	NNS
cord-264884-ydkigome	559	9	of	of	IN
cord-264884-ydkigome	559	10	even	even	RB
cord-264884-ydkigome	559	11	a	a	DT
cord-264884-ydkigome	559	12	single	single	JJ
cord-264884-ydkigome	559	13	viral	viral	JJ
cord-264884-ydkigome	559	14	lineage	lineage	NN
cord-264884-ydkigome	559	15	can	can	MD
cord-264884-ydkigome	559	16	greatly	greatly	RB
cord-264884-ydkigome	559	17	affect	affect	VB
cord-264884-ydkigome	559	18	the	the	DT
cord-264884-ydkigome	559	19	virus	virus	NN
cord-264884-ydkigome	559	20	-	-	HYPH
cord-264884-ydkigome	559	21	host	host	NN
cord-264884-ydkigome	559	22	relationship	relationship	NN
cord-264884-ydkigome	559	23	.	.	.
cord-264884-ydkigome	560	1	Such	such	JJ
cord-264884-ydkigome	560	2	subviral	subviral	JJ
cord-264884-ydkigome	560	3	elements	element	NNS
cord-264884-ydkigome	560	4	(	(	-LRB-
cord-264884-ydkigome	560	5	DIs	DIs	NNP
cord-264884-ydkigome	560	6	)	)	-RRB-
cord-264884-ydkigome	560	7	have	have	VBP
cord-264884-ydkigome	560	8	been	be	VBN
cord-264884-ydkigome	560	9	observed	observe	VBN
cord-264884-ydkigome	560	10	to	to	IN
cord-264884-ydkigome	560	11	both	both	DT
cord-264884-ydkigome	560	12	reduce	reduce	VB
cord-264884-ydkigome	560	13	and	and	CC
cord-264884-ydkigome	560	14	intensify	intensify	VB
cord-264884-ydkigome	560	15	disease	disease	NN
cord-264884-ydkigome	560	16	,	,	,
cord-264884-ydkigome	560	17	and	and	CC
cord-264884-ydkigome	560	18	also	also	RB
cord-264884-ydkigome	560	19	interact	interact	VB
cord-264884-ydkigome	560	20	with	with	IN
cord-264884-ydkigome	560	21	satellite	satellite	NN
cord-264884-ydkigome	560	22	viruses	virus	NNS
cord-264884-ydkigome	560	23	(	(	-LRB-
cord-264884-ydkigome	560	24	Qiu	Qiu	NNP
cord-264884-ydkigome	560	25	and	and	CC
cord-264884-ydkigome	560	26	Scholthof	Scholthof	NNP
cord-264884-ydkigome	560	27	,	,	,
cord-264884-ydkigome	560	28	2001	2001	CD
cord-264884-ydkigome	560	29	)	)	-RRB-
cord-264884-ydkigome	560	30	,	,	,
cord-264884-ydkigome	560	31	thus	thus	RB
cord-264884-ydkigome	560	32	virus	virus	NN
cord-264884-ydkigome	560	33	-	-	HYPH
cord-264884-ydkigome	560	34	virus	virus	NN
cord-264884-ydkigome	560	35	interactions	interaction	NNS
cord-264884-ydkigome	560	36	are	be	VBP
cord-264884-ydkigome	560	37	clearly	clearly	RB
cord-264884-ydkigome	560	38	crucial	crucial	JJ
cord-264884-ydkigome	560	39	in	in	IN
cord-264884-ydkigome	560	40	many	many	JJ
cord-264884-ydkigome	560	41	situations	situation	NNS
cord-264884-ydkigome	560	42	(	(	-LRB-
cord-264884-ydkigome	560	43	Simon	Simon	NNP
cord-264884-ydkigome	560	44	et	et	NNP
cord-264884-ydkigome	560	45	al	al	NNP
cord-264884-ydkigome	560	46	.	.	NNP
cord-264884-ydkigome	560	47	,	,	,
cord-264884-ydkigome	560	48	2004	2004	CD
cord-264884-ydkigome	560	49	)	)	-RRB-
cord-264884-ydkigome	560	50	and	and	CC
cord-264884-ydkigome	560	51	viral	viral	JJ
cord-264884-ydkigome	560	52	interactions	interaction	NNS
cord-264884-ydkigome	560	53	and	and	CC
cord-264884-ydkigome	560	54	synergism	synergism	NN
cord-264884-ydkigome	560	55	appear	appear	VBP
cord-264884-ydkigome	560	56	to	to	TO
cord-264884-ydkigome	560	57	have	have	VB
cord-264884-ydkigome	560	58	led	lead	VBN
cord-264884-ydkigome	560	59	to	to	IN
cord-264884-ydkigome	560	60	signifi	signifi	NNP
cord-264884-ydkigome	561	1	ca	can	MD
cord-264884-ydkigome	561	2	nt	not	RB
cord-264884-ydkigome	561	3	events	event	NNS
cord-264884-ydkigome	561	4	in	in	IN
cord-264884-ydkigome	561	5	plant	plant	NN
cord-264884-ydkigome	561	6	virus	virus	NN
cord-264884-ydkigome	561	7	emergence	emergence	NN
cord-264884-ydkigome	561	8	(	(	-LRB-
cord-264884-ydkigome	561	9	Fargette	Fargette	NNP
cord-264884-ydkigome	561	10	et	et	NNP
cord-264884-ydkigome	561	11	al	al	NNP
cord-264884-ydkigome	561	12	.	.	NNP
cord-264884-ydkigome	561	13	,	,	,
cord-264884-ydkigome	561	14	2006	2006	CD
cord-264884-ydkigome	561	15	)	)	-RRB-
cord-264884-ydkigome	561	16	.	.	.
cord-264884-ydkigome	562	1	Virus	virus	NN
cord-264884-ydkigome	562	2	-	-	HYPH
cord-264884-ydkigome	562	3	virus	virus	NN
cord-264884-ydkigome	562	4	interactions	interaction	NNS
cord-264884-ydkigome	562	5	are	be	VBP
cord-264884-ydkigome	562	6	not	not	RB
cord-264884-ydkigome	562	7	limited	limit	VBN
cord-264884-ydkigome	562	8	to	to	TO
cord-264884-ydkigome	562	9	plant	plant	VB
cord-264884-ydkigome	562	10	RNA	RNA	NNP
cord-264884-ydkigome	562	11	viruses	virus	NNS
cord-264884-ydkigome	562	12	.	.	.
cord-264884-ydkigome	563	1	The	the	DT
cord-264884-ydkigome	563	2	ssDNA	ssdna	JJ
cord-264884-ydkigome	563	3	plant	plant	NN
cord-264884-ydkigome	563	4	geminiviruses	geminiviruses	NNP
cord-264884-ydkigome	563	5	also	also	RB
cord-264884-ydkigome	563	6	display	display	VBP
cord-264884-ydkigome	563	7	complex	complex	JJ
cord-264884-ydkigome	563	8	interactions	interaction	NNS
cord-264884-ydkigome	563	9	with	with	IN
cord-264884-ydkigome	563	10	satellites	satellite	NNS
cord-264884-ydkigome	563	11	as	as	RB
cord-264884-ydkigome	563	12	well	well	RB
cord-264884-ydkigome	563	13	as	as	IN
cord-264884-ydkigome	563	14	high	high	JJ
cord-264884-ydkigome	563	15	diversity	diversity	NN
cord-264884-ydkigome	563	16	in	in	IN
cord-264884-ydkigome	563	17	fi	fi	NNP
cord-264884-ydkigome	563	18	eld	eld	NNP
cord-264884-ydkigome	563	19	isolates	isolate	NNS
cord-264884-ydkigome	563	20	of	of	IN
cord-264884-ydkigome	563	21	East	East	NNP
cord-264884-ydkigome	563	22	Africa	Africa	NNP
cord-264884-ydkigome	564	1	(	(	-LRB-
cord-264884-ydkigome	564	2	Ndunguru	Ndunguru	NNP
cord-264884-ydkigome	564	3	et	et	NNP
cord-264884-ydkigome	564	4	al	al	NNP
cord-264884-ydkigome	564	5	.	.	NNP
cord-264884-ydkigome	564	6	,	,	,
cord-264884-ydkigome	564	7	2005	2005	CD
cord-264884-ydkigome	564	8	)	)	-RRB-
cord-264884-ydkigome	564	9	.	.	.
cord-264884-ydkigome	565	1	Thus	thus	RB
cord-264884-ydkigome	565	2	,	,	,
cord-264884-ydkigome	565	3	plant	plant	NN
cord-264884-ydkigome	565	4	viruses	virus	NNS
cord-264884-ydkigome	565	5	seem	seem	VBP
cord-264884-ydkigome	565	6	particularly	particularly	RB
cord-264884-ydkigome	565	7	prone	prone	JJ
cord-264884-ydkigome	565	8	to	to	IN
cord-264884-ydkigome	565	9	interactions	interaction	NNS
cord-264884-ydkigome	565	10	.	.	.
cord-264884-ydkigome	566	1	More	more	RBR
cord-264884-ydkigome	566	2	recently	recently	RB
cord-264884-ydkigome	566	3	,	,	,
cord-264884-ydkigome	566	4	virus	virus	NN
cord-264884-ydkigome	566	5	-	-	HYPH
cord-264884-ydkigome	566	6	mediated	mediate	VBN
cord-264884-ydkigome	566	7	symbiosis	symbiosis	NN
cord-264884-ydkigome	566	8	with	with	IN
cord-264884-ydkigome	566	9	respect	respect	NN
cord-264884-ydkigome	566	10	to	to	IN
cord-264884-ydkigome	566	11	host	host	NN
cord-264884-ydkigome	566	12	survival	survival	NN
cord-264884-ydkigome	566	13	has	have	VBZ
cord-264884-ydkigome	566	14	been	be	VBN
cord-264884-ydkigome	566	15	reported	report	VBN
cord-264884-ydkigome	566	16	(	(	-LRB-
cord-264884-ydkigome	566	17	Roossinck	Roossinck	NNP
cord-264884-ydkigome	566	18	,	,	,
cord-264884-ydkigome	566	19	2005	2005	CD
cord-264884-ydkigome	566	20	)	)	-RRB-
cord-264884-ydkigome	566	21	(	(	-LRB-
cord-264884-ydkigome	566	22	discussed	discuss	VBN
cord-264884-ydkigome	566	23	below	below	RB
cord-264884-ydkigome	566	24	)	)	-RRB-
cord-264884-ydkigome	566	25	.	.	.
cord-264884-ydkigome	567	1	Phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	567	2	methods	method	NNS
cord-264884-ydkigome	567	3	also	also	RB
cord-264884-ydkigome	567	4	struggle	struggle	VBP
cord-264884-ydkigome	567	5	to	to	TO
cord-264884-ydkigome	567	6	address	address	VB
cord-264884-ydkigome	567	7	the	the	DT
cord-264884-ydkigome	567	8	occurrence	occurrence	NN
cord-264884-ydkigome	567	9	of	of	IN
cord-264884-ydkigome	567	10	high	high	JJ
cord-264884-ydkigome	567	11	rates	rate	NNS
cord-264884-ydkigome	567	12	of	of	IN
cord-264884-ydkigome	567	13	recombination	recombination	NN
cord-264884-ydkigome	567	14	in	in	IN
cord-264884-ydkigome	567	15	viral	viral	JJ
cord-264884-ydkigome	567	16	lineages	lineage	NNS
cord-264884-ydkigome	567	17	.	.	.
cord-264884-ydkigome	568	1	Such	such	PDT
cord-264884-ydkigome	568	2	a	a	DT
cord-264884-ydkigome	568	3	situation	situation	NN
cord-264884-ydkigome	568	4	complicates	complicate	VBZ
cord-264884-ydkigome	568	5	the	the	DT
cord-264884-ydkigome	568	6	analysis	analysis	NN
cord-264884-ydkigome	568	7	,	,	,
cord-264884-ydkigome	568	8	creating	create	VBG
cord-264884-ydkigome	568	9	hardto	hardto	VB
cord-264884-ydkigome	568	10	-	-	HYPH
cord-264884-ydkigome	568	11	defi	defi	NNP
cord-264884-ydkigome	568	12	ne	ne	NNP
cord-264884-ydkigome	568	13	,	,	,
cord-264884-ydkigome	568	14	reticulated	reticulated	JJ
cord-264884-ydkigome	568	15	trees	tree	NNS
cord-264884-ydkigome	568	16	,	,	,
cord-264884-ydkigome	568	17	although	although	IN
cord-264884-ydkigome	568	18	these	these	DT
cord-264884-ydkigome	568	19	limitations	limitation	NNS
cord-264884-ydkigome	568	20	can	can	MD
cord-264884-ydkigome	568	21	be	be	VB
cord-264884-ydkigome	568	22	partially	partially	RB
cord-264884-ydkigome	568	23	overcome	overcome	VBN
cord-264884-ydkigome	568	24	by	by	IN
cord-264884-ydkigome	568	25	using	use	VBG
cord-264884-ydkigome	568	26	sliding	slide	VBG
cord-264884-ydkigome	568	27	windows	window	NNS
cord-264884-ydkigome	568	28	for	for	IN
cord-264884-ydkigome	568	29	the	the	DT
cord-264884-ydkigome	568	30	analysis	analysis	NN
cord-264884-ydkigome	568	31	.	.	.
cord-264884-ydkigome	569	1	Such	such	JJ
cord-264884-ydkigome	569	2	approaches	approach	NNS
cord-264884-ydkigome	569	3	have	have	VBP
cord-264884-ydkigome	569	4	allowed	allow	VBN
cord-264884-ydkigome	569	5	surveys	survey	NNS
cord-264884-ydkigome	569	6	of	of	IN
cord-264884-ydkigome	569	7	recombination	recombination	NN
cord-264884-ydkigome	569	8	in	in	IN
cord-264884-ydkigome	569	9	some	some	DT
cord-264884-ydkigome	569	10	viral	viral	JJ
cord-264884-ydkigome	569	11	lineages	lineage	NNS
cord-264884-ydkigome	569	12	,	,	,
cord-264884-ydkigome	569	13	such	such	JJ
cord-264884-ydkigome	569	14	as	as	IN
cord-264884-ydkigome	569	15	with	with	IN
cord-264884-ydkigome	569	16	the	the	DT
cord-264884-ydkigome	569	17	plant	plant	NN
cord-264884-ydkigome	569	18	potyviruses	potyviruse	NNS
cord-264884-ydkigome	569	19	(	(	-LRB-
cord-264884-ydkigome	569	20	Chare	Chare	NNP
cord-264884-ydkigome	569	21	and	and	CC
cord-264884-ydkigome	569	22	Holmes	Holmes	NNP
cord-264884-ydkigome	569	23	,	,	,
cord-264884-ydkigome	569	24	2006	2006	CD
cord-264884-ydkigome	569	25	)	)	-RRB-
cord-264884-ydkigome	569	26	.	.	.
cord-264884-ydkigome	570	1	However	however	RB
cord-264884-ydkigome	570	2	,	,	,
cord-264884-ydkigome	570	3	the	the	DT
cord-264884-ydkigome	570	4	rampant	rampant	JJ
cord-264884-ydkigome	570	5	recombination	recombination	NN
cord-264884-ydkigome	570	6	and	and	CC
cord-264884-ydkigome	570	7	quasispecies	quasispecie	NNS
cord-264884-ydkigome	570	8	generation	generation	NN
cord-264884-ydkigome	570	9	of	of	IN
cord-264884-ydkigome	570	10	HIV-1	HIV-1	NNP
cord-264884-ydkigome	570	11	makes	make	VBZ
cord-264884-ydkigome	570	12	a	a	DT
cord-264884-ydkigome	570	13	quantitative	quantitative	JJ
cord-264884-ydkigome	570	14	assessment	assessment	NN
cord-264884-ydkigome	570	15	of	of	IN
cord-264884-ydkigome	570	16	the	the	DT
cord-264884-ydkigome	570	17	virus	virus	NN
cord-264884-ydkigome	570	18	population	population	NN
cord-264884-ydkigome	570	19	problematic	problematic	JJ
cord-264884-ydkigome	570	20	.	.	.
cord-264884-ydkigome	571	1	One	one	CD
cord-264884-ydkigome	571	2	proposed	propose	VBN
cord-264884-ydkigome	571	3	solution	solution	NN
cord-264884-ydkigome	571	4	is	be	VBZ
cord-264884-ydkigome	571	5	to	to	TO
cord-264884-ydkigome	571	6	use	use	VB
cord-264884-ydkigome	571	7	a	a	DT
cord-264884-ydkigome	571	8	composition	composition	NN
cord-264884-ydkigome	571	9	vector	vector	NN
cord-264884-ydkigome	571	10	method	method	NN
cord-264884-ydkigome	571	11	(	(	-LRB-
cord-264884-ydkigome	571	12	Gao	Gao	NNP
cord-264884-ydkigome	571	13	and	and	CC
cord-264884-ydkigome	571	14	Qi	Qi	NNP
cord-264884-ydkigome	571	15	,	,	,
cord-264884-ydkigome	571	16	2007	2007	CD
cord-264884-ydkigome	571	17	)	)	-RRB-
cord-264884-ydkigome	571	18	.	.	.
cord-264884-ydkigome	572	1	The	the	DT
cord-264884-ydkigome	572	2	issue	issue	NN
cord-264884-ydkigome	572	3	of	of	IN
cord-264884-ydkigome	572	4	measuring	measure	VBG
cord-264884-ydkigome	572	5	recombination	recombination	NN
cord-264884-ydkigome	572	6	and	and	CC
cord-264884-ydkigome	572	7	tracing	trace	VBG
cord-264884-ydkigome	572	8	evolution	evolution	NN
cord-264884-ydkigome	572	9	in	in	IN
cord-264884-ydkigome	572	10	large	large	JJ
cord-264884-ydkigome	572	11	populations	population	NNS
cord-264884-ydkigome	572	12	is	be	VBZ
cord-264884-ydkigome	572	13	especially	especially	RB
cord-264884-ydkigome	572	14	a	a	DT
cord-264884-ydkigome	572	15	problem	problem	NN
cord-264884-ydkigome	572	16	that	that	WDT
cord-264884-ydkigome	572	17	applies	apply	VBZ
cord-264884-ydkigome	572	18	to	to	IN
cord-264884-ydkigome	572	19	the	the	DT
cord-264884-ydkigome	572	20	DNA	dna	NN
cord-264884-ydkigome	572	21	viruses	virus	NNS
cord-264884-ydkigome	572	22	(	(	-LRB-
cord-264884-ydkigome	572	23	phage	phage	NN
cord-264884-ydkigome	572	24	)	)	-RRB-
cord-264884-ydkigome	572	25	of	of	IN
cord-264884-ydkigome	572	26	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	572	27	(	(	-LRB-
cord-264884-ydkigome	572	28	see	see	VB
cord-264884-ydkigome	572	29	below	below	RB
cord-264884-ydkigome	572	30	)	)	-RRB-
cord-264884-ydkigome	572	31	.	.	.
cord-264884-ydkigome	573	1	Cells	cell	NNS
cord-264884-ydkigome	573	2	.	.	.
cord-264884-ydkigome	574	1	Our	-PRON-	PRP$
cord-264884-ydkigome	574	2	perception	perception	NN
cord-264884-ydkigome	574	3	regarding	regard	VBG
cord-264884-ydkigome	574	4	the	the	DT
cord-264884-ydkigome	574	5	overall	overall	JJ
cord-264884-ydkigome	574	6	importance	importance	NN
cord-264884-ydkigome	574	7	of	of	IN
cord-264884-ydkigome	574	8	DNA	dna	NN
cord-264884-ydkigome	574	9	viruses	virus	NNS
cord-264884-ydkigome	574	10	of	of	IN
cord-264884-ydkigome	574	11	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	574	12	to	to	IN
cord-264884-ydkigome	574	13	the	the	DT
cord-264884-ydkigome	574	14	evolution	evolution	NN
cord-264884-ydkigome	574	15	of	of	IN
cord-264884-ydkigome	574	16	life	life	NN
cord-264884-ydkigome	574	17	on	on	IN
cord-264884-ydkigome	574	18	Earth	Earth	NNP
cord-264884-ydkigome	574	19	has	have	VBZ
cord-264884-ydkigome	574	20	undergone	undergo	VBN
cord-264884-ydkigome	574	21	a	a	DT
cord-264884-ydkigome	574	22	major	major	JJ
cord-264884-ydkigome	574	23	shift	shift	NN
cord-264884-ydkigome	574	24	in	in	IN
cord-264884-ydkigome	574	25	recent	recent	JJ
cord-264884-ydkigome	574	26	years	year	NNS
cord-264884-ydkigome	574	27	.	.	.
cord-264884-ydkigome	575	1	The	the	DT
cord-264884-ydkigome	575	2	main	main	JJ
cord-264884-ydkigome	575	3	realization	realization	NN
cord-264884-ydkigome	575	4	is	be	VBZ
cord-264884-ydkigome	575	5	that	that	IN
cord-264884-ydkigome	575	6	DNA	dna	NN
cord-264884-ydkigome	575	7	phage	phage	NN
cord-264884-ydkigome	575	8	are	be	VBP
cord-264884-ydkigome	575	9	the	the	DT
cord-264884-ydkigome	575	10	numerically	numerically	RB
cord-264884-ydkigome	575	11	dominant	dominant	JJ
cord-264884-ydkigome	575	12	genetic	genetic	JJ
cord-264884-ydkigome	575	13	entity	entity	NN
cord-264884-ydkigome	575	14	in	in	IN
cord-264884-ydkigome	575	15	most	most	JJS
cord-264884-ydkigome	575	16	habitats	habitat	NNS
cord-264884-ydkigome	575	17	on	on	IN
cord-264884-ydkigome	575	18	Earth	Earth	NNP
cord-264884-ydkigome	575	19	(	(	-LRB-
cord-264884-ydkigome	575	20	mentioned	mention	VBN
cord-264884-ydkigome	575	21	above	above	RB
cord-264884-ydkigome	575	22	)	)	-RRB-
cord-264884-ydkigome	575	23	.	.	.
cord-264884-ydkigome	576	1	In	in	IN
cord-264884-ydkigome	576	2	addition	addition	NN
cord-264884-ydkigome	576	3	,	,	,
cord-264884-ydkigome	576	4	as	as	IN
cord-264884-ydkigome	576	5	discussed	discuss	VBN
cord-264884-ydkigome	576	6	in	in	IN
cord-264884-ydkigome	576	7	Chapter	chapter	NN
cord-264884-ydkigome	576	8	10	10	CD
cord-264884-ydkigome	576	9	,	,	,
cord-264884-ydkigome	576	10	it	-PRON-	PRP
cord-264884-ydkigome	576	11	is	be	VBZ
cord-264884-ydkigome	576	12	now	now	RB
cord-264884-ydkigome	576	13	clear	clear	JJ
cord-264884-ydkigome	576	14	that	that	IN
cord-264884-ydkigome	576	15	some	some	DT
cord-264884-ydkigome	576	16	of	of	IN
cord-264884-ydkigome	576	17	these	these	DT
cord-264884-ydkigome	576	18	viruses	virus	NNS
cord-264884-ydkigome	576	19	are	be	VBP
cord-264884-ydkigome	576	20	surprisingly	surprisingly	RB
cord-264884-ydkigome	576	21	complex	complex	JJ
cord-264884-ydkigome	576	22	and	and	CC
cord-264884-ydkigome	576	23	that	that	IN
cord-264884-ydkigome	576	24	essentially	essentially	RB
cord-264884-ydkigome	576	25	the	the	DT
cord-264884-ydkigome	576	26	entire	entire	JJ
cord-264884-ydkigome	576	27	pool	pool	NN
cord-264884-ydkigome	576	28	of	of	IN
cord-264884-ydkigome	576	29	dsDNA	dsdna	JJ
cord-264884-ydkigome	576	30	viruses	virus	NNS
cord-264884-ydkigome	576	31	of	of	IN
cord-264884-ydkigome	576	32	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	576	33	may	may	MD
cord-264884-ydkigome	576	34	be	be	VB
cord-264884-ydkigome	576	35	exchanging	exchange	VBG
cord-264884-ydkigome	576	36	DNA	dna	NN
cord-264884-ydkigome	576	37	via	via	IN
cord-264884-ydkigome	576	38	recombination	recombination	NN
cord-264884-ydkigome	576	39	at	at	IN
cord-264884-ydkigome	576	40	high	high	JJ
cord-264884-ydkigome	576	41	rates	rate	NNS
cord-264884-ydkigome	576	42	.	.	.
cord-264884-ydkigome	577	1	This	this	DT
cord-264884-ydkigome	577	2	would	would	MD
cord-264884-ydkigome	577	3	constitute	constitute	VB
cord-264884-ydkigome	577	4	by	by	IN
cord-264884-ydkigome	577	5	far	far	RB
cord-264884-ydkigome	577	6	the	the	DT
cord-264884-ydkigome	577	7	largest	large	JJS
cord-264884-ydkigome	577	8	common	common	JJ
cord-264884-ydkigome	577	9	gene	gene	NN
cord-264884-ydkigome	577	10	pool	pool	NN
cord-264884-ydkigome	577	11	on	on	IN
cord-264884-ydkigome	577	12	Earth	Earth	NNP
cord-264884-ydkigome	577	13	.	.	.
cord-264884-ydkigome	578	1	Historically	historically	RB
cord-264884-ydkigome	578	2	,	,	,
cord-264884-ydkigome	578	3	the	the	DT
cord-264884-ydkigome	578	4	evolution	evolution	NN
cord-264884-ydkigome	578	5	of	of	IN
cord-264884-ydkigome	578	6	the	the	DT
cord-264884-ydkigome	578	7	DNA	dna	NN
cord-264884-ydkigome	578	8	viruses	virus	NNS
cord-264884-ydkigome	578	9	of	of	IN
cord-264884-ydkigome	578	10	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	578	11	has	have	VBZ
cord-264884-ydkigome	578	12	seldom	seldom	RB
cord-264884-ydkigome	578	13	been	be	VBN
cord-264884-ydkigome	578	14	considered	consider	VBN
cord-264884-ydkigome	578	15	in	in	IN
cord-264884-ydkigome	578	16	the	the	DT
cord-264884-ydkigome	578	17	broader	broad	JJR
cord-264884-ydkigome	578	18	context	context	NN
cord-264884-ydkigome	578	19	of	of	IN
cord-264884-ydkigome	578	20	virus	virus	NN
cord-264884-ydkigome	578	21	evolution	evolution	NN
cord-264884-ydkigome	578	22	or	or	CC
cord-264884-ydkigome	578	23	evolutionary	evolutionary	JJ
cord-264884-ydkigome	578	24	biology	biology	NN
cord-264884-ydkigome	578	25	.	.	.
cord-264884-ydkigome	579	1	Although	although	IN
cord-264884-ydkigome	579	2	it	-PRON-	PRP
cord-264884-ydkigome	579	3	has	have	VBZ
cord-264884-ydkigome	579	4	long	long	RB
cord-264884-ydkigome	579	5	been	be	VBN
cord-264884-ydkigome	579	6	realized	realize	VBN
cord-264884-ydkigome	579	7	that	that	IN
cord-264884-ydkigome	579	8	there	there	EX
cord-264884-ydkigome	579	9	are	be	VBP
cord-264884-ydkigome	579	10	many	many	JJ
cord-264884-ydkigome	579	11	basic	basic	JJ
cord-264884-ydkigome	579	12	similarities	similarity	NNS
cord-264884-ydkigome	579	13	between	between	IN
cord-264884-ydkigome	579	14	viruses	virus	NNS
cord-264884-ydkigome	579	15	of	of	IN
cord-264884-ydkigome	579	16	bacteria	bacteria	NNS
cord-264884-ydkigome	579	17	and	and	CC
cord-264884-ydkigome	579	18	eukaryotes	eukaryote	NNS
cord-264884-ydkigome	580	1	(	(	-LRB-
cord-264884-ydkigome	580	2	Luria	Luria	NNP
cord-264884-ydkigome	580	3	et	et	NNP
cord-264884-ydkigome	580	4	al	al	NNP
cord-264884-ydkigome	580	5	.	.	NNP
cord-264884-ydkigome	580	6	,	,	,
cord-264884-ydkigome	580	7	1959	1959	CD
cord-264884-ydkigome	580	8	)	)	-RRB-
cord-264884-ydkigome	580	9	,	,	,
cord-264884-ydkigome	580	10	not	not	RB
cord-264884-ydkigome	580	11	until	until	IN
cord-264884-ydkigome	580	12	structural	structural	JJ
cord-264884-ydkigome	580	13	studies	study	NNS
cord-264884-ydkigome	580	14	solved	solve	VBD
cord-264884-ydkigome	580	15	the	the	DT
cord-264884-ydkigome	580	16	capsid	capsid	JJ
cord-264884-ydkigome	580	17	genes	gene	NNS
cord-264884-ydkigome	580	18	of	of	IN
cord-264884-ydkigome	580	19	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	580	20	and	and	CC
cord-264884-ydkigome	580	21	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	580	22	viruses	virus	NNS
cord-264884-ydkigome	580	23	did	do	VBD
cord-264884-ydkigome	580	24	the	the	DT
cord-264884-ydkigome	580	25	evolutionary	evolutionary	JJ
cord-264884-ydkigome	580	26	relationships	relationship	NNS
cord-264884-ydkigome	580	27	between	between	IN
cord-264884-ydkigome	580	28	these	these	DT
cord-264884-ydkigome	580	29	viruses	virus	NNS
cord-264884-ydkigome	580	30	become	become	VBP
cord-264884-ydkigome	580	31	clear	clear	JJ
cord-264884-ydkigome	580	32	.	.	.
cord-264884-ydkigome	581	1	In	in	IN
cord-264884-ydkigome	581	2	addition	addition	NN
cord-264884-ydkigome	581	3	,	,	,
cord-264884-ydkigome	581	4	there	there	EX
cord-264884-ydkigome	581	5	have	have	VBP
cord-264884-ydkigome	581	6	been	be	VBN
cord-264884-ydkigome	581	7	a	a	DT
cord-264884-ydkigome	581	8	number	number	NN
cord-264884-ydkigome	581	9	of	of	IN
cord-264884-ydkigome	581	10	striking	striking	JJ
cord-264884-ydkigome	581	11	proposals	proposal	NNS
cord-264884-ydkigome	581	12	that	that	WDT
cord-264884-ydkigome	581	13	suggest	suggest	VBP
cord-264884-ydkigome	581	14	that	that	IN
cord-264884-ydkigome	581	15	DNA	dna	NN
cord-264884-ydkigome	581	16	viruses	virus	NNS
cord-264884-ydkigome	581	17	of	of	IN
cord-264884-ydkigome	581	18	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	581	19	may	may	MD
cord-264884-ydkigome	581	20	be	be	VB
cord-264884-ydkigome	581	21	involved	involve	VBN
cord-264884-ydkigome	581	22	in	in	IN
cord-264884-ydkigome	581	23	the	the	DT
cord-264884-ydkigome	581	24	origin	origin	NN
cord-264884-ydkigome	581	25	of	of	IN
cord-264884-ydkigome	581	26	several	several	JJ
cord-264884-ydkigome	581	27	major	major	JJ
cord-264884-ydkigome	581	28	systems	system	NNS
cord-264884-ydkigome	581	29	used	use	VBN
cord-264884-ydkigome	581	30	by	by	IN
cord-264884-ydkigome	581	31	cells	cell	NNS
cord-264884-ydkigome	581	32	and	and	CC
cord-264884-ydkigome	581	33	that	that	IN
cord-264884-ydkigome	581	34	viruses	virus	NNS
cord-264884-ydkigome	581	35	appear	appear	VBP
cord-264884-ydkigome	581	36	to	to	TO
cord-264884-ydkigome	581	37	be	be	VB
cord-264884-ydkigome	581	38	involved	involve	VBN
cord-264884-ydkigome	581	39	in	in	IN
cord-264884-ydkigome	581	40	several	several	JJ
cord-264884-ydkigome	581	41	major	major	JJ
cord-264884-ydkigome	581	42	transitions	transition	NNS
cord-264884-ydkigome	581	43	during	during	IN
cord-264884-ydkigome	581	44	host	host	NN
cord-264884-ydkigome	581	45	evolution	evolution	NN
cord-264884-ydkigome	581	46	.	.	.
cord-264884-ydkigome	582	1	Thus	thus	RB
cord-264884-ydkigome	582	2	we	-PRON-	PRP
cord-264884-ydkigome	582	3	now	now	RB
cord-264884-ydkigome	582	4	consider	consider	VBP
cord-264884-ydkigome	582	5	the	the	DT
cord-264884-ydkigome	582	6	possibility	possibility	NN
cord-264884-ydkigome	582	7	that	that	IN
cord-264884-ydkigome	582	8	these	these	DT
cord-264884-ydkigome	582	9	DNA	dna	NN
cord-264884-ydkigome	582	10	phage	phage	NN
cord-264884-ydkigome	582	11	were	be	VBD
cord-264884-ydkigome	582	12	fundamental	fundamental	JJ
cord-264884-ydkigome	582	13	to	to	IN
cord-264884-ydkigome	582	14	the	the	DT
cord-264884-ydkigome	582	15	origin	origin	NN
cord-264884-ydkigome	582	16	and	and	CC
cord-264884-ydkigome	582	17	evolution	evolution	NN
cord-264884-ydkigome	582	18	of	of	IN
cord-264884-ydkigome	582	19	life	life	NN
cord-264884-ydkigome	582	20	on	on	IN
cord-264884-ydkigome	582	21	Earth	Earth	NNP
cord-264884-ydkigome	582	22	.	.	.
cord-264884-ydkigome	583	1	It	-PRON-	PRP
cord-264884-ydkigome	583	2	now	now	RB
cord-264884-ydkigome	583	3	seems	seem	VBZ
cord-264884-ydkigome	583	4	likely	likely	JJ
cord-264884-ydkigome	583	5	that	that	IN
cord-264884-ydkigome	583	6	some	some	DT
cord-264884-ydkigome	583	7	large	large	JJ
cord-264884-ydkigome	583	8	DNA	dna	NN
cord-264884-ydkigome	583	9	viruses	virus	NNS
cord-264884-ydkigome	583	10	infecting	infect	VBG
cord-264884-ydkigome	583	11	eubacteria	eubacteria	NNP
cord-264884-ydkigome	583	12	,	,	,
cord-264884-ydkigome	583	13	archaea	archaea	NNP
cord-264884-ydkigome	583	14	,	,	,
cord-264884-ydkigome	583	15	and	and	CC
cord-264884-ydkigome	583	16	eukaryotes	eukaryote	NNS
cord-264884-ydkigome	583	17	share	share	VBP
cord-264884-ydkigome	583	18	some	some	DT
cord-264884-ydkigome	583	19	common	common	JJ
cord-264884-ydkigome	583	20	evolutionary	evolutionary	JJ
cord-264884-ydkigome	583	21	histories	history	NNS
cord-264884-ydkigome	583	22	.	.	.
cord-264884-ydkigome	584	1	It	-PRON-	PRP
cord-264884-ydkigome	584	2	also	also	RB
cord-264884-ydkigome	584	3	seems	seem	VBZ
cord-264884-ydkigome	584	4	clear	clear	JJ
cord-264884-ydkigome	584	5	that	that	IN
cord-264884-ydkigome	584	6	such	such	JJ
cord-264884-ydkigome	584	7	viruses	virus	NNS
cord-264884-ydkigome	584	8	can	can	MD
cord-264884-ydkigome	584	9	link	link	VB
cord-264884-ydkigome	584	10	all	all	DT
cord-264884-ydkigome	584	11	three	three	CD
cord-264884-ydkigome	584	12	domains	domain	NNS
cord-264884-ydkigome	584	13	of	of	IN
cord-264884-ydkigome	584	14	life	life	NN
cord-264884-ydkigome	584	15	.	.	.
cord-264884-ydkigome	585	1	This	this	DT
cord-264884-ydkigome	585	2	realization	realization	NN
cord-264884-ydkigome	585	3	was	be	VBD
cord-264884-ydkigome	585	4	not	not	RB
cord-264884-ydkigome	585	5	apparent	apparent	JJ
cord-264884-ydkigome	585	6	based	base	VBN
cord-264884-ydkigome	585	7	on	on	IN
cord-264884-ydkigome	585	8	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	585	9	sequence	sequence	NN
cord-264884-ydkigome	585	10	conservation	conservation	NN
cord-264884-ydkigome	585	11	,	,	,
cord-264884-ydkigome	585	12	which	which	WDT
cord-264884-ydkigome	585	13	is	be	VBZ
cord-264884-ydkigome	585	14	absent	absent	JJ
cord-264884-ydkigome	585	15	.	.	.
cord-264884-ydkigome	586	1	It	-PRON-	PRP
cord-264884-ydkigome	586	2	stems	stem	VBZ
cord-264884-ydkigome	586	3	from	from	IN
cord-264884-ydkigome	586	4	the	the	DT
cord-264884-ydkigome	586	5	structure	structure	NN
cord-264884-ydkigome	586	6	and	and	CC
cord-264884-ydkigome	586	7	assembly	assembly	NN
cord-264884-ydkigome	586	8	of	of	IN
cord-264884-ydkigome	586	9	virion	virion	NNP
cord-264884-ydkigome	586	10	capsids	capsid	NNS
cord-264884-ydkigome	586	11	in	in	IN
cord-264884-ydkigome	586	12	which	which	WDT
cord-264884-ydkigome	586	13	T4	T4	NNP
cord-264884-ydkigome	586	14	phage	phage	NN
cord-264884-ydkigome	586	15	,	,	,
cord-264884-ydkigome	586	16	halophage	halophage	NNP
cord-264884-ydkigome	586	17	,	,	,
cord-264884-ydkigome	586	18	and	and	CC
cord-264884-ydkigome	586	19	the	the	DT
cord-264884-ydkigome	586	20	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	586	21	all	all	DT
cord-264884-ydkigome	586	22	show	show	VBP
cord-264884-ydkigome	586	23	clear	clear	JJ
cord-264884-ydkigome	586	24	similarity	similarity	NN
cord-264884-ydkigome	586	25	as	as	RB
cord-264884-ydkigome	586	26	well	well	RB
cord-264884-ydkigome	586	27	as	as	IN
cord-264884-ydkigome	586	28	similarity	similarity	NN
cord-264884-ydkigome	586	29	in	in	IN
cord-264884-ydkigome	586	30	replication	replication	NN
cord-264884-ydkigome	586	31	strategies	strategy	NNS
cord-264884-ydkigome	586	32	.	.	.
cord-264884-ydkigome	587	1	In	in	IN
cord-264884-ydkigome	587	2	addition	addition	NN
cord-264884-ydkigome	587	3	,	,	,
cord-264884-ydkigome	587	4	phage	phage	NN
cord-264884-ydkigome	587	5	PRD1	PRD1	NNP
cord-264884-ydkigome	587	6	and	and	CC
cord-264884-ydkigome	587	7	adenoviruses	adenovirus	NNS
cord-264884-ydkigome	587	8	show	show	VBP
cord-264884-ydkigome	587	9	similar	similar	JJ
cord-264884-ydkigome	587	10	broad	broad	JJ
cord-264884-ydkigome	587	11	structural	structural	JJ
cord-264884-ydkigome	587	12	and	and	CC
cord-264884-ydkigome	587	13	strategic	strategic	JJ
cord-264884-ydkigome	587	14	conservation	conservation	NN
cord-264884-ydkigome	587	15	.	.	.
cord-264884-ydkigome	588	1	Some	some	DT
cord-264884-ydkigome	588	2	biochemical	biochemical	JJ
cord-264884-ydkigome	588	3	(	(	-LRB-
cord-264884-ydkigome	588	4	DNA	dna	NN
cord-264884-ydkigome	588	5	pol	pol	NN
cord-264884-ydkigome	588	6	family	family	NN
cord-264884-ydkigome	588	7	)	)	-RRB-
cord-264884-ydkigome	588	8	and	and	CC
cord-264884-ydkigome	588	9	genetic	genetic	JJ
cord-264884-ydkigome	588	10	similarities	similarity	NNS
cord-264884-ydkigome	588	11	(	(	-LRB-
cord-264884-ydkigome	588	12	gene	gene	NN
cord-264884-ydkigome	588	13	order	order	NN
cord-264884-ydkigome	588	14	,	,	,
cord-264884-ydkigome	588	15	gene	gene	NN
cord-264884-ydkigome	588	16	programming	programming	NN
cord-264884-ydkigome	588	17	)	)	-RRB-
cord-264884-ydkigome	588	18	are	be	VBP
cord-264884-ydkigome	588	19	also	also	RB
cord-264884-ydkigome	588	20	apparent	apparent	JJ
cord-264884-ydkigome	588	21	,	,	,
cord-264884-ydkigome	588	22	which	which	WDT
cord-264884-ydkigome	588	23	taken	take	VBN
cord-264884-ydkigome	588	24	together	together	RB
cord-264884-ydkigome	588	25	supports	support	VBZ
cord-264884-ydkigome	588	26	the	the	DT
cord-264884-ydkigome	588	27	common	common	JJ
cord-264884-ydkigome	588	28	origins	origin	NNS
cord-264884-ydkigome	588	29	of	of	IN
cord-264884-ydkigome	588	30	these	these	DT
cord-264884-ydkigome	588	31	viruses	virus	NNS
cord-264884-ydkigome	588	32	(	(	-LRB-
cord-264884-ydkigome	588	33	Hendrix	Hendrix	NNP
cord-264884-ydkigome	588	34	,	,	,
cord-264884-ydkigome	588	35	1999	1999	CD
cord-264884-ydkigome	588	36	(	(	-LRB-
cord-264884-ydkigome	588	37	Hendrix	Hendrix	NNP
cord-264884-ydkigome	588	38	,	,	,
cord-264884-ydkigome	588	39	,	,	,
cord-264884-ydkigome	588	40	2002	2002	CD
cord-264884-ydkigome	588	41	Hendrix	Hendrix	NNP
cord-264884-ydkigome	588	42	et	et	NNP
cord-264884-ydkigome	588	43	al	al	NNP
cord-264884-ydkigome	588	44	.	.	NNP
cord-264884-ydkigome	588	45	,	,	,
cord-264884-ydkigome	588	46	1999	1999	CD
cord-264884-ydkigome	588	47	Hendrix	Hendrix	NNP
cord-264884-ydkigome	588	48	et	et	NNP
cord-264884-ydkigome	588	49	al	al	NNP
cord-264884-ydkigome	588	50	.	.	NNP
cord-264884-ydkigome	588	51	,	,	,
cord-264884-ydkigome	588	52	,	,	,
cord-264884-ydkigome	588	53	2003	2003	CD
cord-264884-ydkigome	588	54	.	.	.
cord-264884-ydkigome	589	1	T4-like	t4-like	IN
cord-264884-ydkigome	589	2	viruses	virus	NNS
cord-264884-ydkigome	589	3	in	in	IN
cord-264884-ydkigome	589	4	particular	particular	JJ
cord-264884-ydkigome	589	5	seem	seem	VBP
cord-264884-ydkigome	589	6	to	to	TO
cord-264884-ydkigome	589	7	represent	represent	VB
cord-264884-ydkigome	589	8	a	a	DT
cord-264884-ydkigome	589	9	major	major	JJ
cord-264884-ydkigome	589	10	source	source	NN
cord-264884-ydkigome	589	11	of	of	IN
cord-264884-ydkigome	589	12	global	global	JJ
cord-264884-ydkigome	589	13	genetic	genetic	JJ
cord-264884-ydkigome	589	14	diversity	diversity	NN
cord-264884-ydkigome	589	15	.	.	.
cord-264884-ydkigome	590	1	This	this	DT
cord-264884-ydkigome	590	2	giant	giant	JJ
cord-264884-ydkigome	590	3	genetic	genetic	JJ
cord-264884-ydkigome	590	4	pool	pool	NN
cord-264884-ydkigome	590	5	represents	represent	VBZ
cord-264884-ydkigome	590	6	a	a	DT
cord-264884-ydkigome	590	7	huge	huge	JJ
cord-264884-ydkigome	590	8	potential	potential	NN
cord-264884-ydkigome	590	9	to	to	TO
cord-264884-ydkigome	590	10	affect	affect	VB
cord-264884-ydkigome	590	11	life	life	NN
cord-264884-ydkigome	590	12	(	(	-LRB-
cord-264884-ydkigome	590	13	Filee	Filee	NNP
cord-264884-ydkigome	590	14	et	et	FW
cord-264884-ydkigome	590	15	al	al	NNP
cord-264884-ydkigome	590	16	.	.	.
cord-264884-ydkigome	591	1	,	,	,
cord-264884-ydkigome	591	2	2005	2005	CD
cord-264884-ydkigome	591	3	)	)	-RRB-
cord-264884-ydkigome	591	4	and	and	CC
cord-264884-ydkigome	591	5	the	the	DT
cord-264884-ydkigome	591	6	viral	viral	JJ
cord-264884-ydkigome	591	7	genetic	genetic	JJ
cord-264884-ydkigome	591	8	creativity	creativity	NN
cord-264884-ydkigome	591	9	represented	represent	VBN
cord-264884-ydkigome	591	10	by	by	IN
cord-264884-ydkigome	591	11	this	this	DT
cord-264884-ydkigome	591	12	pool	pool	NN
cord-264884-ydkigome	591	13	would	would	MD
cord-264884-ydkigome	591	14	also	also	RB
cord-264884-ydkigome	591	15	be	be	VB
cord-264884-ydkigome	591	16	vast	vast	JJ
cord-264884-ydkigome	592	1	(	(	-LRB-
cord-264884-ydkigome	592	2	Nolan	Nolan	NNP
cord-264884-ydkigome	592	3	et	et	NNP
cord-264884-ydkigome	592	4	al	al	NNP
cord-264884-ydkigome	592	5	.	.	NNP
cord-264884-ydkigome	592	6	,	,	,
cord-264884-ydkigome	592	7	2006	2006	CD
cord-264884-ydkigome	592	8	)	)	-RRB-
cord-264884-ydkigome	592	9	.	.	.
cord-264884-ydkigome	593	1	Since	since	IN
cord-264884-ydkigome	593	2	T4-like	t4-like	CD
cord-264884-ydkigome	593	3	phage	phage	NN
cord-264884-ydkigome	593	4	that	that	WDT
cord-264884-ydkigome	593	5	infect	infect	VBP
cord-264884-ydkigome	593	6	cyanobacteria	cyanobacteria	NNS
cord-264884-ydkigome	593	7	also	also	RB
cord-264884-ydkigome	593	8	encode	encode	VBP
cord-264884-ydkigome	593	9	virus	virus	NN
cord-264884-ydkigome	593	10	-	-	HYPH
cord-264884-ydkigome	593	11	specifi	specifi	VBN
cord-264884-ydkigome	593	12	c	c	NN
cord-264884-ydkigome	593	13	type	type	NN
cord-264884-ydkigome	593	14	II	ii	CD
cord-264884-ydkigome	593	15	photosynthetic	photosynthetic	JJ
cord-264884-ydkigome	593	16	core	core	NN
cord-264884-ydkigome	593	17	genes	gene	NNS
cord-264884-ydkigome	593	18	,	,	,
cord-264884-ydkigome	593	19	viruses	virus	NNS
cord-264884-ydkigome	593	20	appear	appear	VBP
cord-264884-ydkigome	593	21	able	able	JJ
cord-264884-ydkigome	593	22	to	to	TO
cord-264884-ydkigome	593	23	create	create	VB
cord-264884-ydkigome	593	24	the	the	DT
cord-264884-ydkigome	593	25	most	most	RBS
cord-264884-ydkigome	593	26	complex	complex	JJ
cord-264884-ydkigome	593	27	of	of	IN
cord-264884-ydkigome	593	28	genes	gene	NNS
cord-264884-ydkigome	593	29	as	as	RB
cord-264884-ydkigome	593	30	well	well	RB
cord-264884-ydkigome	594	1	(	(	-LRB-
cord-264884-ydkigome	594	2	Clokie	Clokie	NNP
cord-264884-ydkigome	594	3	et	et	NNP
cord-264884-ydkigome	594	4	al	al	NNP
cord-264884-ydkigome	594	5	.	.	NNP
cord-264884-ydkigome	594	6	,	,	,
cord-264884-ydkigome	594	7	2006	2006	CD
cord-264884-ydkigome	595	1	;	;	:
cord-264884-ydkigome	595	2	Sullivan	Sullivan	NNP
cord-264884-ydkigome	595	3	et	et	NNP
cord-264884-ydkigome	595	4	al	al	NNP
cord-264884-ydkigome	595	5	.	.	NNP
cord-264884-ydkigome	595	6	,	,	,
cord-264884-ydkigome	595	7	2006	2006	CD
cord-264884-ydkigome	595	8	)	)	-RRB-
cord-264884-ydkigome	595	9	.	.	.
cord-264884-ydkigome	596	1	As	as	IN
cord-264884-ydkigome	596	2	presented	present	VBN
cord-264884-ydkigome	596	3	in	in	IN
cord-264884-ydkigome	596	4	Chapter	chapter	NN
cord-264884-ydkigome	596	5	10	10	CD
cord-264884-ydkigome	596	6	,	,	,
cord-264884-ydkigome	596	7	phage	phage	NN
cord-264884-ydkigome	596	8	are	be	VBP
cord-264884-ydkigome	596	9	now	now	RB
cord-264884-ydkigome	596	10	thought	think	VBN
cord-264884-ydkigome	596	11	to	to	TO
cord-264884-ydkigome	596	12	evolve	evolve	VB
cord-264884-ydkigome	596	13	by	by	IN
cord-264884-ydkigome	596	14	distinct	distinct	JJ
cord-264884-ydkigome	596	15	and	and	CC
cord-264884-ydkigome	596	16	highly	highly	RB
cord-264884-ydkigome	596	17	mosaic	mosaic	JJ
cord-264884-ydkigome	596	18	"	"	``
cord-264884-ydkigome	596	19	horizontal	horizontal	JJ
cord-264884-ydkigome	596	20	"	"	''
cord-264884-ydkigome	596	21	processes	process	NNS
cord-264884-ydkigome	596	22	of	of	IN
cord-264884-ydkigome	596	23	rampant	rampant	JJ
cord-264884-ydkigome	596	24	recombination	recombination	NN
cord-264884-ydkigome	596	25	(	(	-LRB-
cord-264884-ydkigome	596	26	Hendrix	Hendrix	NNP
cord-264884-ydkigome	596	27	,	,	,
cord-264884-ydkigome	596	28	2002	2002	CD
cord-264884-ydkigome	596	29	(	(	-LRB-
cord-264884-ydkigome	596	30	Hendrix	Hendrix	NNP
cord-264884-ydkigome	596	31	,	,	,
cord-264884-ydkigome	596	32	,	,	,
cord-264884-ydkigome	596	33	2003	2003	CD
cord-264884-ydkigome	596	34	.	.	.
cord-264884-ydkigome	597	1	Large	large	JJ
cord-264884-ydkigome	597	2	DNA	dna	NN
cord-264884-ydkigome	597	3	phage	phage	NN
cord-264884-ydkigome	597	4	appear	appear	VBP
cord-264884-ydkigome	597	5	to	to	TO
cord-264884-ydkigome	597	6	be	be	VB
cord-264884-ydkigome	597	7	ancient	ancient	JJ
cord-264884-ydkigome	597	8	,	,	,
cord-264884-ydkigome	597	9	present	present	JJ
cord-264884-ydkigome	597	10	before	before	IN
cord-264884-ydkigome	597	11	the	the	DT
cord-264884-ydkigome	597	12	split	split	NN
cord-264884-ydkigome	597	13	of	of	IN
cord-264884-ydkigome	597	14	the	the	DT
cord-264884-ydkigome	597	15	three	three	CD
cord-264884-ydkigome	597	16	main	main	JJ
cord-264884-ydkigome	597	17	branches	branch	NNS
cord-264884-ydkigome	597	18	of	of	IN
cord-264884-ydkigome	597	19	cellular	cellular	JJ
cord-264884-ydkigome	597	20	life	life	NN
cord-264884-ydkigome	597	21	:	:	:
cord-264884-ydkigome	598	1	bacteria	bacteria	NNS
cord-264884-ydkigome	598	2	,	,	,
cord-264884-ydkigome	598	3	archaea	archaea	NNS
cord-264884-ydkigome	598	4	,	,	,
cord-264884-ydkigome	598	5	and	and	CC
cord-264884-ydkigome	598	6	eukarya	eukarya	NNP
cord-264884-ydkigome	598	7	(	(	-LRB-
cord-264884-ydkigome	598	8	Benson	Benson	NNP
cord-264884-ydkigome	598	9	et	et	NNP
cord-264884-ydkigome	598	10	al	al	NNP
cord-264884-ydkigome	598	11	.	.	NNP
cord-264884-ydkigome	598	12	,	,	,
cord-264884-ydkigome	598	13	2004	2004	CD
cord-264884-ydkigome	598	14	)	)	-RRB-
cord-264884-ydkigome	598	15	.	.	.
cord-264884-ydkigome	599	1	LUCA	LUCA	NNP
cord-264884-ydkigome	599	2	,	,	,
cord-264884-ydkigome	599	3	the	the	DT
cord-264884-ydkigome	599	4	Last	last	JJ
cord-264884-ydkigome	599	5	Universal	Universal	NNP
cord-264884-ydkigome	599	6	Common	Common	NNP
cord-264884-ydkigome	599	7	Ancestor	Ancestor	NNP
cord-264884-ydkigome	599	8	,	,	,
cord-264884-ydkigome	599	9	would	would	MD
cord-264884-ydkigome	599	10	represent	represent	VB
cord-264884-ydkigome	599	11	the	the	DT
cord-264884-ydkigome	599	12	putative	putative	JJ
cord-264884-ydkigome	599	13	cell	cell	NN
cord-264884-ydkigome	599	14	ancestor	ancestor	NN
cord-264884-ydkigome	599	15	prior	prior	RB
cord-264884-ydkigome	599	16	to	to	IN
cord-264884-ydkigome	599	17	this	this	DT
cord-264884-ydkigome	599	18	split	split	NN
cord-264884-ydkigome	599	19	.	.	.
cord-264884-ydkigome	600	1	However	however	RB
cord-264884-ydkigome	600	2	,	,	,
cord-264884-ydkigome	600	3	phyogenetic	phyogenetic	JJ
cord-264884-ydkigome	600	4	analysis	analysis	NN
cord-264884-ydkigome	600	5	of	of	IN
cord-264884-ydkigome	600	6	common	common	JJ
cord-264884-ydkigome	600	7	or	or	CC
cord-264884-ydkigome	600	8	conserved	conserved	JJ
cord-264884-ydkigome	600	9	genes	gene	NNS
cord-264884-ydkigome	600	10	of	of	IN
cord-264884-ydkigome	600	11	LUCA	LUCA	NNP
cord-264884-ydkigome	600	12	identifi	identifi	NNP
cord-264884-ydkigome	600	13	es	es	NNP
cord-264884-ydkigome	600	14	only	only	RB
cord-264884-ydkigome	600	15	about	about	IN
cord-264884-ydkigome	600	16	325	325	CD
cord-264884-ydkigome	600	17	or	or	CC
cord-264884-ydkigome	600	18	fewer	few	JJR
cord-264884-ydkigome	600	19	genes	gene	NNS
cord-264884-ydkigome	600	20	in	in	IN
cord-264884-ydkigome	600	21	extant	extant	JJ
cord-264884-ydkigome	600	22	cellular	cellular	JJ
cord-264884-ydkigome	600	23	genomes	genome	NNS
cord-264884-ydkigome	600	24	(	(	-LRB-
cord-264884-ydkigome	600	25	Mushegian	Mushegian	NNP
cord-264884-ydkigome	600	26	,	,	,
cord-264884-ydkigome	600	27	1999	1999	CD
cord-264884-ydkigome	600	28	;	;	:
cord-264884-ydkigome	600	29	Koonin	Koonin	NNP
cord-264884-ydkigome	600	30	et	et	NNP
cord-264884-ydkigome	600	31	al	al	NNP
cord-264884-ydkigome	600	32	.	.	NNP
cord-264884-ydkigome	600	33	,	,	,
cord-264884-ydkigome	600	34	2001	2001	CD
cord-264884-ydkigome	600	35	;	;	:
cord-264884-ydkigome	600	36	Mirkin	Mirkin	NNP
cord-264884-ydkigome	600	37	et	et	NNP
cord-264884-ydkigome	600	38	al	al	NNP
cord-264884-ydkigome	600	39	.	.	NNP
cord-264884-ydkigome	600	40	,	,	,
cord-264884-ydkigome	600	41	2003	2003	CD
cord-264884-ydkigome	600	42	)	)	-RRB-
cord-264884-ydkigome	600	43	.	.	.
cord-264884-ydkigome	601	1	Ironically	ironically	RB
cord-264884-ydkigome	601	2	,	,	,
cord-264884-ydkigome	601	3	the	the	DT
cord-264884-ydkigome	601	4	genes	gene	NNS
cord-264884-ydkigome	601	5	needed	need	VBD
cord-264884-ydkigome	601	6	for	for	IN
cord-264884-ydkigome	601	7	DNA	dna	NN
cord-264884-ydkigome	601	8	replication	replication	NN
cord-264884-ydkigome	601	9	are	be	VBP
cord-264884-ydkigome	601	10	not	not	RB
cord-264884-ydkigome	601	11	part	part	NN
cord-264884-ydkigome	601	12	of	of	IN
cord-264884-ydkigome	601	13	this	this	DT
cord-264884-ydkigome	601	14	conserved	conserve	VBN
cord-264884-ydkigome	601	15	set	set	NN
cord-264884-ydkigome	601	16	,	,	,
cord-264884-ydkigome	601	17	calling	call	VBG
cord-264884-ydkigome	601	18	into	into	IN
cord-264884-ydkigome	601	19	question	question	NN
cord-264884-ydkigome	601	20	the	the	DT
cord-264884-ydkigome	601	21	nature	nature	NN
cord-264884-ydkigome	601	22	of	of	IN
cord-264884-ydkigome	601	23	the	the	DT
cord-264884-ydkigome	601	24	fi	fi	NNP
cord-264884-ydkigome	601	25	rst	rst	NNP
cord-264884-ydkigome	601	26	DNA	dna	NN
cord-264884-ydkigome	601	27	-	-	HYPH
cord-264884-ydkigome	601	28	based	base	VBN
cord-264884-ydkigome	601	29	cell	cell	NN
cord-264884-ydkigome	601	30	.	.	.
cord-264884-ydkigome	602	1	Large	large	JJ
cord-264884-ydkigome	602	2	-	-	HYPH
cord-264884-ydkigome	602	3	scale	scale	NN
cord-264884-ydkigome	602	4	"	"	``
cord-264884-ydkigome	602	5	horizontal	horizontal	JJ
cord-264884-ydkigome	602	6	"	"	''
cord-264884-ydkigome	602	7	transfer	transfer	NN
cord-264884-ydkigome	602	8	seems	seem	VBZ
cord-264884-ydkigome	602	9	to	to	TO
cord-264884-ydkigome	602	10	have	have	VB
cord-264884-ydkigome	602	11	clearly	clearly	RB
cord-264884-ydkigome	602	12	prevailed	prevail	VBN
cord-264884-ydkigome	602	13	early	early	RB
cord-264884-ydkigome	602	14	in	in	IN
cord-264884-ydkigome	602	15	the	the	DT
cord-264884-ydkigome	602	16	evolution	evolution	NN
cord-264884-ydkigome	602	17	of	of	IN
cord-264884-ydkigome	602	18	DNA	dna	NN
cord-264884-ydkigome	602	19	-	-	HYPH
cord-264884-ydkigome	602	20	based	base	VBN
cord-264884-ydkigome	602	21	cellular	cellular	JJ
cord-264884-ydkigome	602	22	life	life	NN
cord-264884-ydkigome	602	23	and	and	CC
cord-264884-ydkigome	602	24	it	-PRON-	PRP
cord-264884-ydkigome	602	25	has	have	VBZ
cord-264884-ydkigome	602	26	recently	recently	RB
cord-264884-ydkigome	602	27	been	be	VBN
cord-264884-ydkigome	602	28	asserted	assert	VBN
cord-264884-ydkigome	602	29	that	that	IN
cord-264884-ydkigome	602	30	LUCA	LUCA	NNP
cord-264884-ydkigome	602	31	existed	exist	VBD
cord-264884-ydkigome	602	32	in	in	IN
cord-264884-ydkigome	602	33	a	a	DT
cord-264884-ydkigome	602	34	highly	highly	RB
cord-264884-ydkigome	602	35	horizontal	horizontal	JJ
cord-264884-ydkigome	602	36	"	"	``
cord-264884-ydkigome	602	37	consortia	consortium	NNS
cord-264884-ydkigome	602	38	"	"	''
cord-264884-ydkigome	602	39	of	of	IN
cord-264884-ydkigome	602	40	cooperative	cooperative	JJ
cord-264884-ydkigome	602	41	genes	gene	NNS
cord-264884-ydkigome	602	42	that	that	WDT
cord-264884-ydkigome	602	43	developed	develop	VBD
cord-264884-ydkigome	602	44	the	the	DT
cord-264884-ydkigome	602	45	common	common	JJ
cord-264884-ydkigome	602	46	genetic	genetic	JJ
cord-264884-ydkigome	602	47	code	code	NN
cord-264884-ydkigome	602	48	(	(	-LRB-
cord-264884-ydkigome	602	49	Vetsigian	Vetsigian	NNP
cord-264884-ydkigome	602	50	et	et	FW
cord-264884-ydkigome	602	51	al	al	NNP
cord-264884-ydkigome	602	52	.	.	NNP
cord-264884-ydkigome	602	53	,	,	,
cord-264884-ydkigome	602	54	2006	2006	CD
cord-264884-ydkigome	602	55	)	)	-RRB-
cord-264884-ydkigome	602	56	.	.	.
cord-264884-ydkigome	603	1	Since	since	IN
cord-264884-ydkigome	603	2	the	the	DT
cord-264884-ydkigome	603	3	DNA	dna	NN
cord-264884-ydkigome	603	4	replication	replication	NN
cord-264884-ydkigome	603	5	proteins	protein	NNS
cord-264884-ydkigome	603	6	in	in	IN
cord-264884-ydkigome	603	7	the	the	DT
cord-264884-ydkigome	603	8	extant	extant	JJ
cord-264884-ydkigome	603	9	three	three	CD
cord-264884-ydkigome	603	10	domains	domain	NNS
cord-264884-ydkigome	603	11	of	of	IN
cord-264884-ydkigome	603	12	life	life	NN
cord-264884-ydkigome	603	13	have	have	VBP
cord-264884-ydkigome	603	14	distinct	distinct	JJ
cord-264884-ydkigome	603	15	compositions	composition	NNS
cord-264884-ydkigome	603	16	,	,	,
cord-264884-ydkigome	603	17	it	-PRON-	PRP
cord-264884-ydkigome	603	18	has	have	VBZ
cord-264884-ydkigome	603	19	been	be	VBN
cord-264884-ydkigome	603	20	proposed	propose	VBN
cord-264884-ydkigome	603	21	by	by	IN
cord-264884-ydkigome	603	22	Forterre	Forterre	NNP
cord-264884-ydkigome	603	23	that	that	IN
cord-264884-ydkigome	603	24	DNA	dna	NN
cord-264884-ydkigome	603	25	viruses	virus	NNS
cord-264884-ydkigome	603	26	and	and	CC
cord-264884-ydkigome	603	27	retroviruses	retrovirus	NNS
cord-264884-ydkigome	603	28	were	be	VBD
cord-264884-ydkigome	603	29	directly	directly	RB
cord-264884-ydkigome	603	30	involved	involve	VBN
cord-264884-ydkigome	603	31	in	in	IN
cord-264884-ydkigome	603	32	the	the	DT
cord-264884-ydkigome	603	33	invention	invention	NN
cord-264884-ydkigome	603	34	of	of	IN
cord-264884-ydkigome	603	35	the	the	DT
cord-264884-ydkigome	603	36	three	three	CD
cord-264884-ydkigome	603	37	extant	extant	JJ
cord-264884-ydkigome	603	38	cellular	cellular	JJ
cord-264884-ydkigome	603	39	DNA	dna	NN
cord-264884-ydkigome	603	40	replication	replication	NN
cord-264884-ydkigome	603	41	systems	system	NNS
cord-264884-ydkigome	603	42	.	.	.
cord-264884-ydkigome	604	1	According	accord	VBG
cord-264884-ydkigome	604	2	to	to	IN
cord-264884-ydkigome	604	3	this	this	DT
cord-264884-ydkigome	604	4	view	view	NN
cord-264884-ydkigome	604	5	,	,	,
cord-264884-ydkigome	604	6	early	early	JJ
cord-264884-ydkigome	604	7	cellular	cellular	JJ
cord-264884-ydkigome	604	8	life	life	NN
cord-264884-ydkigome	604	9	was	be	VBD
cord-264884-ydkigome	604	10	completely	completely	RB
cord-264884-ydkigome	604	11	entangled	entangle	VBN
cord-264884-ydkigome	604	12	with	with	IN
cord-264884-ydkigome	604	13	viral	viral	JJ
cord-264884-ydkigome	604	14	(	(	-LRB-
cord-264884-ydkigome	604	15	phage	phage	NN
cord-264884-ydkigome	604	16	)	)	-RRB-
cord-264884-ydkigome	604	17	lineages	lineage	NNS
cord-264884-ydkigome	604	18	;	;	:
cord-264884-ydkigome	604	19	hence	hence	RB
cord-264884-ydkigome	604	20	cells	cell	NNS
cord-264884-ydkigome	604	21	must	must	MD
cord-264884-ydkigome	604	22	have	have	VB
cord-264884-ydkigome	604	23	evolved	evolve	VBN
cord-264884-ydkigome	604	24	from	from	IN
cord-264884-ydkigome	604	25	an	an	DT
cord-264884-ydkigome	604	26	ancestral	ancestral	JJ
cord-264884-ydkigome	604	27	"	"	``
cord-264884-ydkigome	604	28	virus	virus	NN
cord-264884-ydkigome	604	29	"	"	''
cord-264884-ydkigome	604	30	-mediated	-mediated	JJ
cord-264884-ydkigome	604	31	population	population	NN
cord-264884-ydkigome	604	32	not	not	RB
cord-264884-ydkigome	604	33	a	a	DT
cord-264884-ydkigome	604	34	single	single	JJ
cord-264884-ydkigome	604	35	genetic	genetic	JJ
cord-264884-ydkigome	604	36	lineage	lineage	NN
cord-264884-ydkigome	604	37	.	.	.
cord-264884-ydkigome	605	1	Thus	thus	RB
cord-264884-ydkigome	605	2	the	the	DT
cord-264884-ydkigome	605	3	evolution	evolution	NN
cord-264884-ydkigome	605	4	of	of	IN
cord-264884-ydkigome	605	5	early	early	JJ
cord-264884-ydkigome	605	6	life	life	NN
cord-264884-ydkigome	605	7	would	would	MD
cord-264884-ydkigome	605	8	have	have	VB
cord-264884-ydkigome	605	9	clear	clear	JJ
cord-264884-ydkigome	605	10	similarity	similarity	NN
cord-264884-ydkigome	605	11	to	to	IN
cord-264884-ydkigome	605	12	the	the	DT
cord-264884-ydkigome	605	13	quasispecies	quasispecie	NNS
cord-264884-ydkigome	605	14	(	(	-LRB-
cord-264884-ydkigome	605	15	consortia	consortium	NNS
cord-264884-ydkigome	605	16	)	)	-RRB-
cord-264884-ydkigome	605	17	state	state	NN
cord-264884-ydkigome	605	18	of	of	IN
cord-264884-ydkigome	605	19	genetic	genetic	JJ
cord-264884-ydkigome	605	20	information	information	NN
cord-264884-ydkigome	605	21	as	as	IN
cord-264884-ydkigome	605	22	seen	see	VBN
cord-264884-ydkigome	605	23	in	in	IN
cord-264884-ydkigome	605	24	RNA	RNA	NNP
cord-264884-ydkigome	605	25	viruses	virus	NNS
cord-264884-ydkigome	605	26	above	above	RB
cord-264884-ydkigome	605	27	.	.	.
cord-264884-ydkigome	606	1	Thus	thus	RB
cord-264884-ydkigome	606	2	the	the	DT
cord-264884-ydkigome	606	3	huge	huge	JJ
cord-264884-ydkigome	606	4	creative	creative	JJ
cord-264884-ydkigome	606	5	and	and	CC
cord-264884-ydkigome	606	6	adaptive	adaptive	JJ
cord-264884-ydkigome	606	7	potential	potential	NN
cord-264884-ydkigome	606	8	of	of	IN
cord-264884-ydkigome	606	9	virus	virus	NN
cord-264884-ydkigome	606	10	would	would	MD
cord-264884-ydkigome	606	11	have	have	VB
cord-264884-ydkigome	606	12	been	be	VBN
cord-264884-ydkigome	606	13	directly	directly	RB
cord-264884-ydkigome	606	14	involved	involve	VBN
cord-264884-ydkigome	606	15	in	in	IN
cord-264884-ydkigome	606	16	the	the	DT
cord-264884-ydkigome	606	17	very	very	RB
cord-264884-ydkigome	606	18	earliest	early	JJS
cord-264884-ydkigome	606	19	evolution	evolution	NN
cord-264884-ydkigome	606	20	of	of	IN
cord-264884-ydkigome	606	21	life	life	NN
cord-264884-ydkigome	606	22	.	.	.
cord-264884-ydkigome	607	1	Clearly	clearly	RB
cord-264884-ydkigome	607	2	,	,	,
cord-264884-ydkigome	607	3	such	such	JJ
cord-264884-ydkigome	607	4	conjectures	conjecture	NNS
cord-264884-ydkigome	607	5	regarding	regard	VBG
cord-264884-ydkigome	607	6	the	the	DT
cord-264884-ydkigome	607	7	most	most	RBS
cord-264884-ydkigome	607	8	ancient	ancient	JJ
cord-264884-ydkigome	607	9	events	event	NNS
cord-264884-ydkigome	607	10	in	in	IN
cord-264884-ydkigome	607	11	the	the	DT
cord-264884-ydkigome	607	12	evolution	evolution	NN
cord-264884-ydkigome	607	13	of	of	IN
cord-264884-ydkigome	607	14	life	life	NN
cord-264884-ydkigome	607	15	are	be	VBP
cord-264884-ydkigome	607	16	hard	hard	JJ
cord-264884-ydkigome	607	17	to	to	TO
cord-264884-ydkigome	607	18	substantiate	substantiate	VB
cord-264884-ydkigome	607	19	.	.	.
cord-264884-ydkigome	608	1	But	but	CC
cord-264884-ydkigome	608	2	,	,	,
cord-264884-ydkigome	608	3	these	these	DT
cord-264884-ydkigome	608	4	theories	theory	NNS
cord-264884-ydkigome	608	5	are	be	VBP
cord-264884-ydkigome	608	6	as	as	RB
cord-264884-ydkigome	608	7	viable	viable	JJ
cord-264884-ydkigome	608	8	as	as	IN
cord-264884-ydkigome	608	9	any	any	DT
cord-264884-ydkigome	608	10	other	other	JJ
cord-264884-ydkigome	608	11	and	and	CC
cord-264884-ydkigome	608	12	deserve	deserve	VBP
cord-264884-ydkigome	608	13	serious	serious	JJ
cord-264884-ydkigome	608	14	consideration	consideration	NN
cord-264884-ydkigome	608	15	.	.	.
cord-264884-ydkigome	609	1	In	in	IN
cord-264884-ydkigome	609	2	spite	spite	NN
cord-264884-ydkigome	609	3	of	of	IN
cord-264884-ydkigome	609	4	this	this	DT
cord-264884-ydkigome	609	5	seemingly	seemingly	RB
cord-264884-ydkigome	609	6	unending	unending	JJ
cord-264884-ydkigome	609	7	mosaic	mosaic	JJ
cord-264884-ydkigome	609	8	exchange	exchange	NN
cord-264884-ydkigome	609	9	in	in	IN
cord-264884-ydkigome	609	10	dsDNA	dsDNA	NNP
cord-264884-ydkigome	609	11	phage	phage	NN
cord-264884-ydkigome	609	12	,	,	,
cord-264884-ydkigome	609	13	some	some	DT
cord-264884-ydkigome	609	14	phage	phage	NN
cord-264884-ydkigome	609	15	isolates	isolate	NNS
cord-264884-ydkigome	609	16	show	show	VBP
cord-264884-ydkigome	609	17	surprisingly	surprisingly	RB
cord-264884-ydkigome	609	18	stable	stable	JJ
cord-264884-ydkigome	609	19	genetic	genetic	JJ
cord-264884-ydkigome	609	20	makeup	makeup	NN
cord-264884-ydkigome	609	21	.	.	.
cord-264884-ydkigome	610	1	We	-PRON-	PRP
cord-264884-ydkigome	610	2	now	now	RB
cord-264884-ydkigome	610	3	accept	accept	VBP
cord-264884-ydkigome	610	4	that	that	IN
cord-264884-ydkigome	610	5	T4-related	t4-relate	VBN
cord-264884-ydkigome	610	6	phage	phage	NN
cord-264884-ydkigome	610	7	are	be	VBP
cord-264884-ydkigome	610	8	an	an	DT
cord-264884-ydkigome	610	9	important	important	JJ
cord-264884-ydkigome	610	10	source	source	NN
cord-264884-ydkigome	610	11	of	of	IN
cord-264884-ydkigome	610	12	the	the	DT
cord-264884-ydkigome	610	13	larger	large	JJR
cord-264884-ydkigome	610	14	global	global	JJ
cord-264884-ydkigome	610	15	phage	phage	NN
cord-264884-ydkigome	610	16	genetic	genetic	JJ
cord-264884-ydkigome	610	17	diversity	diversity	NN
cord-264884-ydkigome	610	18	and	and	CC
cord-264884-ydkigome	610	19	that	that	IN
cord-264884-ydkigome	610	20	most	most	RBS
cord-264884-ydkigome	610	21	such	such	JJ
cord-264884-ydkigome	610	22	viral	viral	JJ
cord-264884-ydkigome	610	23	genes	gene	NNS
cord-264884-ydkigome	610	24	are	be	VBP
cord-264884-ydkigome	610	25	novel	novel	JJ
cord-264884-ydkigome	611	1	(	(	-LRB-
cord-264884-ydkigome	611	2	Filee	Filee	NNP
cord-264884-ydkigome	611	3	et	et	FW
cord-264884-ydkigome	611	4	al	al	NNP
cord-264884-ydkigome	611	5	.	.	.
cord-264884-ydkigome	612	1	,	,	,
cord-264884-ydkigome	612	2	2006b	2006b	CD
cord-264884-ydkigome	612	3	;	;	:
cord-264884-ydkigome	612	4	Nolan	Nolan	NNP
cord-264884-ydkigome	612	5	et	et	NNP
cord-264884-ydkigome	612	6	al	al	NNP
cord-264884-ydkigome	612	7	.	.	NNP
cord-264884-ydkigome	612	8	,	,	,
cord-264884-ydkigome	612	9	2006	2006	CD
cord-264884-ydkigome	612	10	)	)	-RRB-
cord-264884-ydkigome	612	11	.	.	.
cord-264884-ydkigome	613	1	Yet	yet	CC
cord-264884-ydkigome	613	2	even	even	RB
cord-264884-ydkigome	613	3	with	with	IN
cord-264884-ydkigome	613	4	T4-like	t4-like	IN
cord-264884-ydkigome	613	5	viruses	virus	NNS
cord-264884-ydkigome	613	6	,	,	,
cord-264884-ydkigome	613	7	there	there	EX
cord-264884-ydkigome	613	8	can	can	MD
cord-264884-ydkigome	613	9	be	be	VB
cord-264884-ydkigome	613	10	clear	clear	JJ
cord-264884-ydkigome	613	11	barriers	barrier	NNS
cord-264884-ydkigome	613	12	to	to	IN
cord-264884-ydkigome	613	13	horizontal	horizontal	JJ
cord-264884-ydkigome	613	14	gene	gene	NN
cord-264884-ydkigome	613	15	transfer	transfer	NN
cord-264884-ydkigome	613	16	which	which	WDT
cord-264884-ydkigome	613	17	promote	promote	VBP
cord-264884-ydkigome	613	18	the	the	DT
cord-264884-ydkigome	613	19	evolution	evolution	NN
cord-264884-ydkigome	613	20	of	of	IN
cord-264884-ydkigome	613	21	stable	stable	JJ
cord-264884-ydkigome	613	22	viral	viral	JJ
cord-264884-ydkigome	613	23	lineages	lineage	NNS
cord-264884-ydkigome	613	24	(	(	-LRB-
cord-264884-ydkigome	613	25	Filee	Filee	NNP
cord-264884-ydkigome	613	26	et	et	FW
cord-264884-ydkigome	613	27	al	al	NNP
cord-264884-ydkigome	613	28	.	.	NNP
cord-264884-ydkigome	613	29	,	,	,
cord-264884-ydkigome	613	30	2006a	2006a	CD
cord-264884-ydkigome	613	31	)	)	-RRB-
cord-264884-ydkigome	613	32	.	.	.
cord-264884-ydkigome	614	1	In	in	IN
cord-264884-ydkigome	614	2	T4-type	t4-type	CD
cord-264884-ydkigome	614	3	phage	phage	NN
cord-264884-ydkigome	614	4	,	,	,
cord-264884-ydkigome	614	5	24	24	CD
cord-264884-ydkigome	614	6	similar	similar	JJ
cord-264884-ydkigome	614	7	core	core	NN
cord-264884-ydkigome	614	8	genes	gene	NNS
cord-264884-ydkigome	614	9	could	could	MD
cord-264884-ydkigome	614	10	be	be	VB
cord-264884-ydkigome	614	11	seen	see	VBN
cord-264884-ydkigome	614	12	in	in	IN
cord-264884-ydkigome	614	13	all	all	DT
cord-264884-ydkigome	614	14	genomes	genome	NNS
cord-264884-ydkigome	614	15	,	,	,
cord-264884-ydkigome	614	16	which	which	WDT
cord-264884-ydkigome	614	17	seem	seem	VBP
cord-264884-ydkigome	614	18	to	to	TO
cord-264884-ydkigome	614	19	be	be	VB
cord-264884-ydkigome	614	20	inherited	inherit	VBN
cord-264884-ydkigome	614	21	in	in	IN
cord-264884-ydkigome	614	22	gene	gene	NN
cord-264884-ydkigome	614	23	blocks	block	NNS
cord-264884-ydkigome	614	24	that	that	WDT
cord-264884-ydkigome	614	25	preclude	preclude	VBP
cord-264884-ydkigome	614	26	recombination	recombination	NN
cord-264884-ydkigome	614	27	.	.	.
cord-264884-ydkigome	615	1	However	however	RB
cord-264884-ydkigome	615	2	,	,	,
cord-264884-ydkigome	615	3	these	these	DT
cord-264884-ydkigome	615	4	blocks	block	NNS
cord-264884-ydkigome	615	5	were	be	VBD
cord-264884-ydkigome	615	6	not	not	RB
cord-264884-ydkigome	615	7	seen	see	VBN
cord-264884-ydkigome	615	8	in	in	IN
cord-264884-ydkigome	615	9	the	the	DT
cord-264884-ydkigome	615	10	broader	broad	JJR
cord-264884-ydkigome	615	11	T	t	NN
cord-264884-ydkigome	615	12	-	-	HYPH
cord-264884-ydkigome	615	13	even	even	RB
cord-264884-ydkigome	615	14	and	and	CC
cord-264884-ydkigome	615	15	pseudo	pseudo	JJ
cord-264884-ydkigome	615	16	T	t	NN
cord-264884-ydkigome	615	17	-	-	HYPH
cord-264884-ydkigome	615	18	even	even	RB
cord-264884-ydkigome	615	19	genomes	genome	NNS
cord-264884-ydkigome	615	20	.	.	.
cord-264884-ydkigome	616	1	Other	other	JJ
cord-264884-ydkigome	616	2	phage	phage	NN
cord-264884-ydkigome	616	3	also	also	RB
cord-264884-ydkigome	616	4	show	show	VBP
cord-264884-ydkigome	616	5	surprising	surprising	JJ
cord-264884-ydkigome	616	6	genetic	genetic	JJ
cord-264884-ydkigome	616	7	stability	stability	NN
cord-264884-ydkigome	616	8	when	when	WRB
cord-264884-ydkigome	616	9	repeatedly	repeatedly	RB
cord-264884-ydkigome	616	10	isolated	isolate	VBN
cord-264884-ydkigome	616	11	from	from	IN
cord-264884-ydkigome	616	12	similar	similar	JJ
cord-264884-ydkigome	616	13	habitats	habitat	NNS
cord-264884-ydkigome	616	14	,	,	,
cord-264884-ydkigome	616	15	such	such	JJ
cord-264884-ydkigome	616	16	as	as	IN
cord-264884-ydkigome	616	17	soil	soil	NN
cord-264884-ydkigome	616	18	phages	phage	NNS
cord-264884-ydkigome	616	19	of	of	IN
cord-264884-ydkigome	616	20	Burkholderia	Burkholderia	NNP
cord-264884-ydkigome	616	21	(	(	-LRB-
cord-264884-ydkigome	616	22	Summer	Summer	NNP
cord-264884-ydkigome	616	23	et	et	NNP
cord-264884-ydkigome	616	24	al	al	NNP
cord-264884-ydkigome	616	25	.	.	NNP
cord-264884-ydkigome	616	26	,	,	,
cord-264884-ydkigome	616	27	2006	2006	CD
cord-264884-ydkigome	616	28	)	)	-RRB-
cord-264884-ydkigome	616	29	and	and	CC
cord-264884-ydkigome	616	30	Bam35	Bam35	NNP
cord-264884-ydkigome	616	31	(	(	-LRB-
cord-264884-ydkigome	616	32	Saren	Saren	NNP
cord-264884-ydkigome	616	33	et	et	NNP
cord-264884-ydkigome	616	34	al	al	NNP
cord-264884-ydkigome	616	35	.	.	NNP
cord-264884-ydkigome	616	36	,	,	,
cord-264884-ydkigome	616	37	2005	2005	CD
cord-264884-ydkigome	616	38	)	)	-RRB-
cord-264884-ydkigome	616	39	as	as	RB
cord-264884-ydkigome	616	40	well	well	RB
cord-264884-ydkigome	616	41	as	as	IN
cord-264884-ydkigome	616	42	some	some	DT
cord-264884-ydkigome	616	43	hot	hot	JJ
cord-264884-ydkigome	616	44	spring	spring	NN
cord-264884-ydkigome	616	45	isolates	isolate	NNS
cord-264884-ydkigome	616	46	(	(	-LRB-
cord-264884-ydkigome	616	47	Khayat	Khayat	NNP
cord-264884-ydkigome	616	48	et	et	NNP
cord-264884-ydkigome	616	49	al	al	NNP
cord-264884-ydkigome	616	50	.	.	NNP
cord-264884-ydkigome	616	51	,	,	,
cord-264884-ydkigome	616	52	2005	2005	CD
cord-264884-ydkigome	616	53	)	)	-RRB-
cord-264884-ydkigome	616	54	.	.	.
cord-264884-ydkigome	617	1	This	this	DT
cord-264884-ydkigome	617	2	Bam35	Bam35	NNP
cord-264884-ydkigome	617	3	capsid	capsid	NN
cord-264884-ydkigome	617	4	also	also	RB
cord-264884-ydkigome	617	5	identifi	identifi	NNP
cord-264884-ydkigome	617	6	es	es	NNP
cord-264884-ydkigome	617	7	another	another	DT
cord-264884-ydkigome	617	8	structural	structural	JJ
cord-264884-ydkigome	617	9	motif	motif	NN
cord-264884-ydkigome	617	10	mentioned	mention	VBN
cord-264884-ydkigome	617	11	above	above	IN
cord-264884-ydkigome	617	12	that	that	DT
cord-264884-ydkigome	617	13	is	be	VBZ
cord-264884-ydkigome	617	14	broadly	broadly	RB
cord-264884-ydkigome	617	15	conserved	conserve	VBN
cord-264884-ydkigome	617	16	in	in	IN
cord-264884-ydkigome	617	17	evolution	evolution	NN
cord-264884-ydkigome	617	18	and	and	CC
cord-264884-ydkigome	617	19	shows	show	VBZ
cord-264884-ydkigome	617	20	clear	clear	JJ
cord-264884-ydkigome	617	21	similarity	similarity	NN
cord-264884-ydkigome	617	22	to	to	IN
cord-264884-ydkigome	617	23	that	that	DT
cord-264884-ydkigome	617	24	capsids	capsid	NNS
cord-264884-ydkigome	617	25	found	find	VBN
cord-264884-ydkigome	617	26	in	in	IN
cord-264884-ydkigome	617	27	PRD1	PRD1	NNP
cord-264884-ydkigome	617	28	and	and	CC
cord-264884-ydkigome	617	29	PBCV-1	PBCV-1	NNP
cord-264884-ydkigome	617	30	(	(	-LRB-
cord-264884-ydkigome	617	31	discussed	discuss	VBN
cord-264884-ydkigome	617	32	below	below	RB
cord-264884-ydkigome	617	33	)	)	-RRB-
cord-264884-ydkigome	617	34	.	.	.
cord-264884-ydkigome	618	1	SH1	SH1	NNP
cord-264884-ydkigome	618	2	also	also	RB
cord-264884-ydkigome	618	3	has	have	VBZ
cord-264884-ydkigome	618	4	a	a	DT
cord-264884-ydkigome	618	5	clear	clear	JJ
cord-264884-ydkigome	618	6	PRD1related	PRD1related	NNP
cord-264884-ydkigome	618	7	capsid	capsid	NN
cord-264884-ydkigome	618	8	,	,	,
cord-264884-ydkigome	618	9	membrane	membrane	NN
cord-264884-ydkigome	618	10	,	,	,
cord-264884-ydkigome	618	11	and	and	CC
cord-264884-ydkigome	618	12	genome	genome	NN
cord-264884-ydkigome	618	13	;	;	:
cord-264884-ydkigome	618	14	thus	thus	RB
cord-264884-ydkigome	618	15	this	this	DT
cord-264884-ydkigome	618	16	halophilic	halophilic	NNP
cord-264884-ydkigome	618	17	euryarchaeon	euryarchaeon	NNP
cord-264884-ydkigome	618	18	virus	virus	NN
cord-264884-ydkigome	618	19	,	,	,
cord-264884-ydkigome	618	20	although	although	IN
cord-264884-ydkigome	618	21	showing	show	VBG
cord-264884-ydkigome	618	22	no	no	DT
cord-264884-ydkigome	618	23	sequence	sequence	NN
cord-264884-ydkigome	618	24	similarity	similarity	NN
cord-264884-ydkigome	618	25	to	to	IN
cord-264884-ydkigome	618	26	PRD1	PRD1	NNP
cord-264884-ydkigome	618	27	or	or	CC
cord-264884-ydkigome	618	28	any	any	DT
cord-264884-ydkigome	618	29	other	other	JJ
cord-264884-ydkigome	618	30	bacterial	bacterial	JJ
cord-264884-ydkigome	618	31	phage	phage	NN
cord-264884-ydkigome	618	32	,	,	,
cord-264884-ydkigome	618	33	is	be	VBZ
cord-264884-ydkigome	618	34	clearly	clearly	RB
cord-264884-ydkigome	618	35	structurally	structurally	RB
cord-264884-ydkigome	618	36	related	related	JJ
cord-264884-ydkigome	619	1	(	(	-LRB-
cord-264884-ydkigome	619	2	Bamford	Bamford	NNP
cord-264884-ydkigome	619	3	et	et	NNP
cord-264884-ydkigome	619	4	al	al	NNP
cord-264884-ydkigome	619	5	.	.	NNP
cord-264884-ydkigome	619	6	,	,	,
cord-264884-ydkigome	619	7	2005a	2005a	CD
cord-264884-ydkigome	619	8	)	)	-RRB-
cord-264884-ydkigome	619	9	.	.	.
cord-264884-ydkigome	620	1	It	-PRON-	PRP
cord-264884-ydkigome	620	2	is	be	VBZ
cord-264884-ydkigome	620	3	interesting	interesting	JJ
cord-264884-ydkigome	620	4	that	that	IN
cord-264884-ydkigome	620	5	overall	overall	JJ
cord-264884-ydkigome	620	6	the	the	DT
cord-264884-ydkigome	620	7	viruses	virus	NNS
cord-264884-ydkigome	620	8	of	of	IN
cord-264884-ydkigome	620	9	hyperthermophilic	hyperthermophilic	NN
cord-264884-ydkigome	620	10	Crenarchaeota	Crenarchaeota	NNP
cord-264884-ydkigome	620	11	generally	generally	RB
cord-264884-ydkigome	620	12	show	show	VBP
cord-264884-ydkigome	620	13	no	no	DT
cord-264884-ydkigome	620	14	sequence	sequence	NN
cord-264884-ydkigome	620	15	relationship	relationship	NN
cord-264884-ydkigome	620	16	to	to	IN
cord-264884-ydkigome	620	17	phage	phage	NN
cord-264884-ydkigome	620	18	of	of	IN
cord-264884-ydkigome	620	19	bacteria	bacteria	NNS
cord-264884-ydkigome	620	20	.	.	.
cord-264884-ydkigome	621	1	In	in	IN
cord-264884-ydkigome	621	2	addition	addition	NN
cord-264884-ydkigome	621	3	,	,	,
cord-264884-ydkigome	621	4	the	the	DT
cord-264884-ydkigome	621	5	use	use	NN
cord-264884-ydkigome	621	6	of	of	IN
cord-264884-ydkigome	621	7	the	the	DT
cord-264884-ydkigome	621	8	term	term	NN
cord-264884-ydkigome	621	9	phage	phage	NN
cord-264884-ydkigome	621	10	for	for	IN
cord-264884-ydkigome	621	11	these	these	DT
cord-264884-ydkigome	621	12	viruses	virus	NNS
cord-264884-ydkigome	621	13	can	can	MD
cord-264884-ydkigome	621	14	also	also	RB
cord-264884-ydkigome	621	15	be	be	VB
cord-264884-ydkigome	621	16	questioned	question	VBN
cord-264884-ydkigome	621	17	as	as	IN
cord-264884-ydkigome	621	18	most	most	JJS
cord-264884-ydkigome	621	19	establish	establish	VBP
cord-264884-ydkigome	621	20	non	non	JJ
cord-264884-ydkigome	621	21	-	-	JJ
cord-264884-ydkigome	621	22	lytic	lytic	JJ
cord-264884-ydkigome	621	23	chronic	chronic	JJ
cord-264884-ydkigome	621	24	infections	infection	NNS
cord-264884-ydkigome	621	25	.	.	.
cord-264884-ydkigome	622	1	Many	many	JJ
cord-264884-ydkigome	622	2	of	of	IN
cord-264884-ydkigome	622	3	these	these	DT
cord-264884-ydkigome	622	4	Crenarchaeota	Crenarchaeota	NNP
cord-264884-ydkigome	622	5	viruses	virus	NNS
cord-264884-ydkigome	622	6	have	have	VBP
cord-264884-ydkigome	622	7	unique	unique	JJ
cord-264884-ydkigome	622	8	morphologies	morphology	NNS
cord-264884-ydkigome	622	9	not	not	RB
cord-264884-ydkigome	622	10	found	find	VBN
cord-264884-ydkigome	622	11	in	in	IN
cord-264884-ydkigome	622	12	any	any	DT
cord-264884-ydkigome	622	13	other	other	JJ
cord-264884-ydkigome	622	14	domain	domain	NN
cord-264884-ydkigome	622	15	of	of	IN
cord-264884-ydkigome	622	16	life	life	NN
cord-264884-ydkigome	623	1	(	(	-LRB-
cord-264884-ydkigome	623	2	Prangishvili	Prangishvili	NNP
cord-264884-ydkigome	623	3	et	et	NNP
cord-264884-ydkigome	623	4	al	al	NNP
cord-264884-ydkigome	623	5	.	.	.
cord-264884-ydkigome	624	1	,	,	,
cord-264884-ydkigome	624	2	2006a	2006a	CD
cord-264884-ydkigome	624	3	(	(	-LRB-
cord-264884-ydkigome	624	4	Prangishvili	Prangishvili	NNP
cord-264884-ydkigome	624	5	et	et	NNP
cord-264884-ydkigome	624	6	al	al	NNP
cord-264884-ydkigome	624	7	.	.	NNP
cord-264884-ydkigome	624	8	,	,	,
cord-264884-ydkigome	624	9	,	,	,
cord-264884-ydkigome	624	10	2006b	2006b	CD
cord-264884-ydkigome	625	1	Ortmann	Ortmann	NNP
cord-264884-ydkigome	625	2	et	et	NNP
cord-264884-ydkigome	625	3	al	al	NNP
cord-264884-ydkigome	625	4	.	.	NNP
cord-264884-ydkigome	625	5	,	,	,
cord-264884-ydkigome	625	6	2006	2006	CD
cord-264884-ydkigome	625	7	)	)	-RRB-
cord-264884-ydkigome	625	8	.	.	.
cord-264884-ydkigome	626	1	Some	some	DT
cord-264884-ydkigome	626	2	,	,	,
cord-264884-ydkigome	626	3	however	however	RB
cord-264884-ydkigome	626	4	,	,	,
cord-264884-ydkigome	626	5	have	have	VBP
cord-264884-ydkigome	626	6	clear	clear	JJ
cord-264884-ydkigome	626	7	structural	structural	JJ
cord-264884-ydkigome	626	8	and	and	CC
cord-264884-ydkigome	626	9	genetic	genetic	JJ
cord-264884-ydkigome	626	10	similarity	similarity	NN
cord-264884-ydkigome	626	11	to	to	IN
cord-264884-ydkigome	626	12	specifi	specifi	NNP
cord-264884-ydkigome	626	13	c	c	NN
cord-264884-ydkigome	626	14	phage	phage	NN
cord-264884-ydkigome	626	15	(	(	-LRB-
cord-264884-ydkigome	626	16	i.e.	i.e.	FW
cord-264884-ydkigome	626	17	T4	T4	NNP
cord-264884-ydkigome	626	18	)	)	-RRB-
cord-264884-ydkigome	626	19	.	.	.
cord-264884-ydkigome	627	1	Considerations	consideration	NNS
cord-264884-ydkigome	627	2	of	of	IN
cord-264884-ydkigome	627	3	phage	phage	NN
cord-264884-ydkigome	627	4	evolution	evolution	NN
cord-264884-ydkigome	627	5	and	and	CC
cord-264884-ydkigome	627	6	rampant	rampant	JJ
cord-264884-ydkigome	627	7	recombination	recombination	NN
cord-264884-ydkigome	627	8	(	(	-LRB-
cord-264884-ydkigome	627	9	especially	especially	RB
cord-264884-ydkigome	627	10	with	with	IN
cord-264884-ydkigome	627	11	T4	T4	NNP
cord-264884-ydkigome	627	12	and	and	CC
cord-264884-ydkigome	627	13	T	T	NNP
cord-264884-ydkigome	627	14	-	-	HYPH
cord-264884-ydkigome	627	15	even	even	RB
cord-264884-ydkigome	627	16	phage	phage	NN
cord-264884-ydkigome	627	17	)	)	-RRB-
cord-264884-ydkigome	627	18	often	often	RB
cord-264884-ydkigome	627	19	emphasize	emphasize	VBP
cord-264884-ydkigome	627	20	the	the	DT
cord-264884-ydkigome	627	21	viral	viral	JJ
cord-264884-ydkigome	627	22	lytic	lytic	JJ
cord-264884-ydkigome	627	23	lifestyle	lifestyle	NN
cord-264884-ydkigome	627	24	and	and	CC
cord-264884-ydkigome	627	25	host	host	NN
cord-264884-ydkigome	627	26	death	death	NN
cord-264884-ydkigome	627	27	.	.	.
cord-264884-ydkigome	628	1	In	in	IN
cord-264884-ydkigome	628	2	fact	fact	NN
cord-264884-ydkigome	628	3	this	this	DT
cord-264884-ydkigome	628	4	lytic	lytic	JJ
cord-264884-ydkigome	628	5	relationship	relationship	NN
cord-264884-ydkigome	628	6	was	be	VBD
cord-264884-ydkigome	628	7	argued	argue	VBN
cord-264884-ydkigome	628	8	by	by	IN
cord-264884-ydkigome	628	9	many	many	JJ
cord-264884-ydkigome	628	10	early	early	JJ
cord-264884-ydkigome	628	11	phage	phage	NN
cord-264884-ydkigome	628	12	researchers	researcher	NNS
cord-264884-ydkigome	628	13	to	to	TO
cord-264884-ydkigome	628	14	be	be	VB
cord-264884-ydkigome	628	15	the	the	DT
cord-264884-ydkigome	628	16	fundamental	fundamental	JJ
cord-264884-ydkigome	628	17	and	and	CC
cord-264884-ydkigome	628	18	only	only	JJ
cord-264884-ydkigome	628	19	character	character	NN
cord-264884-ydkigome	628	20	of	of	IN
cord-264884-ydkigome	628	21	phage	phage	NN
cord-264884-ydkigome	628	22	-	-	HYPH
cord-264884-ydkigome	628	23	host	host	NN
cord-264884-ydkigome	628	24	relationships	relationship	NNS
cord-264884-ydkigome	628	25	in	in	IN
cord-264884-ydkigome	628	26	general	general	JJ
cord-264884-ydkigome	628	27	.	.	.
cord-264884-ydkigome	629	1	We	-PRON-	PRP
cord-264884-ydkigome	629	2	now	now	RB
cord-264884-ydkigome	629	3	know	know	VBP
cord-264884-ydkigome	629	4	,	,	,
cord-264884-ydkigome	629	5	however	however	RB
cord-264884-ydkigome	629	6	,	,	,
cord-264884-ydkigome	629	7	that	that	IN
cord-264884-ydkigome	629	8	persisting	persist	VBG
cord-264884-ydkigome	629	9	(	(	-LRB-
cord-264884-ydkigome	629	10	temperate	temperate	JJ
cord-264884-ydkigome	629	11	)	)	-RRB-
cord-264884-ydkigome	629	12	phage	phage	NN
cord-264884-ydkigome	629	13	are	be	VBP
cord-264884-ydkigome	629	14	also	also	RB
cord-264884-ydkigome	629	15	common	common	JJ
cord-264884-ydkigome	629	16	,	,	,
cord-264884-ydkigome	629	17	some	some	DT
cord-264884-ydkigome	629	18	of	of	IN
cord-264884-ydkigome	629	19	which	which	WDT
cord-264884-ydkigome	629	20	have	have	VBP
cord-264884-ydkigome	629	21	no	no	DT
cord-264884-ydkigome	629	22	independent	independent	JJ
cord-264884-ydkigome	629	23	lytic	lytic	JJ
cord-264884-ydkigome	629	24	phase	phase	NN
cord-264884-ydkigome	629	25	.	.	.
cord-264884-ydkigome	630	1	The	the	DT
cord-264884-ydkigome	630	2	fundamental	fundamental	JJ
cord-264884-ydkigome	630	3	model	model	NN
cord-264884-ydkigome	630	4	of	of	IN
cord-264884-ydkigome	630	5	phage	phage	NN
cord-264884-ydkigome	630	6	persistence	persistence	NN
cord-264884-ydkigome	630	7	by	by	IN
cord-264884-ydkigome	630	8	unique	unique	JJ
cord-264884-ydkigome	630	9	integration	integration	NN
cord-264884-ydkigome	630	10	into	into	IN
cord-264884-ydkigome	630	11	host	host	NN
cord-264884-ydkigome	630	12	chromosomes	chromosome	NNS
cord-264884-ydkigome	630	13	(	(	-LRB-
cord-264884-ydkigome	630	14	temperate	temperate	JJ
cord-264884-ydkigome	630	15	lysogeny	lysogeny	NNP
cord-264884-ydkigome	630	16	)	)	-RRB-
cord-264884-ydkigome	630	17	marks	mark	VBZ
cord-264884-ydkigome	630	18	a	a	DT
cord-264884-ydkigome	630	19	major	major	JJ
cord-264884-ydkigome	630	20	development	development	NN
cord-264884-ydkigome	630	21	in	in	IN
cord-264884-ydkigome	630	22	our	-PRON-	PRP$
cord-264884-ydkigome	630	23	understanding	understanding	NN
cord-264884-ydkigome	630	24	of	of	IN
cord-264884-ydkigome	630	25	molecular	molecular	JJ
cord-264884-ydkigome	630	26	virology	virology	NN
cord-264884-ydkigome	630	27	and	and	CC
cord-264884-ydkigome	630	28	virus	virus	NN
cord-264884-ydkigome	630	29	-	-	HYPH
cord-264884-ydkigome	630	30	host	host	NN
cord-264884-ydkigome	630	31	relationships	relationship	NNS
cord-264884-ydkigome	630	32	which	which	WDT
cord-264884-ydkigome	630	33	was	be	VBD
cord-264884-ydkigome	630	34	fi	fi	FW
cord-264884-ydkigome	630	35	rst	rst	FW
cord-264884-ydkigome	630	36	clarifi	clarifi	NNP
cord-264884-ydkigome	630	37	ed	ed	NN
cord-264884-ydkigome	630	38	by	by	IN
cord-264884-ydkigome	630	39	Campbell	Campbell	NNP
cord-264884-ydkigome	630	40	in	in	IN
cord-264884-ydkigome	630	41	1962	1962	CD
cord-264884-ydkigome	630	42	(	(	-LRB-
cord-264884-ydkigome	630	43	see	see	VB
cord-264884-ydkigome	630	44	Campbell	Campbell	NNP
cord-264884-ydkigome	630	45	,	,	,
cord-264884-ydkigome	630	46	2007	2007	CD
cord-264884-ydkigome	630	47	.	.	.
cord-264884-ydkigome	631	1	All	all	DT
cord-264884-ydkigome	631	2	free	free	RB
cord-264884-ydkigome	631	3	-	-	HYPH
cord-264884-ydkigome	631	4	living	live	VBG
cord-264884-ydkigome	631	5	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	631	6	show	show	VBP
cord-264884-ydkigome	631	7	the	the	DT
cord-264884-ydkigome	631	8	presence	presence	NN
cord-264884-ydkigome	631	9	of	of	IN
cord-264884-ydkigome	631	10	colonized	colonize	VBN
cord-264884-ydkigome	631	11	phage	phage	NN
cord-264884-ydkigome	631	12	in	in	IN
cord-264884-ydkigome	631	13	their	-PRON-	PRP$
cord-264884-ydkigome	631	14	genomes	genome	NNS
cord-264884-ydkigome	631	15	.	.	.
cord-264884-ydkigome	632	1	Both	both	DT
cord-264884-ydkigome	632	2	complete	complete	JJ
cord-264884-ydkigome	632	3	and	and	CC
cord-264884-ydkigome	632	4	defective	defective	JJ
cord-264884-ydkigome	632	5	genomes	genome	NNS
cord-264884-ydkigome	632	6	of	of	IN
cord-264884-ydkigome	632	7	dsDNA	dsdna	JJ
cord-264884-ydkigome	632	8	viruses	virus	NNS
cord-264884-ydkigome	632	9	have	have	VBP
cord-264884-ydkigome	632	10	been	be	VBN
cord-264884-ydkigome	632	11	observed	observe	VBN
cord-264884-ydkigome	632	12	in	in	IN
cord-264884-ydkigome	632	13	the	the	DT
cord-264884-ydkigome	632	14	sequenced	sequence	VBN
cord-264884-ydkigome	632	15	DNA	dna	NN
cord-264884-ydkigome	632	16	of	of	IN
cord-264884-ydkigome	632	17	all	all	DT
cord-264884-ydkigome	632	18	free	free	JJ
cord-264884-ydkigome	632	19	living	living	NN
cord-264884-ydkigome	632	20	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	632	21	genomes	genome	NNS
cord-264884-ydkigome	632	22	(	(	-LRB-
cord-264884-ydkigome	632	23	Gelfand	Gelfand	NNP
cord-264884-ydkigome	632	24	and	and	CC
cord-264884-ydkigome	632	25	Koonin	Koonin	NNP
cord-264884-ydkigome	632	26	,	,	,
cord-264884-ydkigome	632	27	1997	1997	CD
cord-264884-ydkigome	632	28	)	)	-RRB-
cord-264884-ydkigome	633	1	(	(	-LRB-
cord-264884-ydkigome	633	2	exceptions	exception	NNS
cord-264884-ydkigome	633	3	are	be	VBP
cord-264884-ydkigome	633	4	some	some	DT
cord-264884-ydkigome	633	5	intracellular	intracellular	JJ
cord-264884-ydkigome	633	6	parasites	parasite	NNS
cord-264884-ydkigome	633	7	and	and	CC
cord-264884-ydkigome	633	8	plastids	plastid	NNS
cord-264884-ydkigome	633	9	)	)	-RRB-
cord-264884-ydkigome	633	10	.	.	.
cord-264884-ydkigome	634	1	Thus	thus	RB
cord-264884-ydkigome	634	2	,	,	,
cord-264884-ydkigome	634	3	the	the	DT
cord-264884-ydkigome	634	4	massive	massive	JJ
cord-264884-ydkigome	634	5	genetic	genetic	JJ
cord-264884-ydkigome	634	6	diversity	diversity	NN
cord-264884-ydkigome	634	7	and	and	CC
cord-264884-ydkigome	634	8	novelty	novelty	NN
cord-264884-ydkigome	634	9	of	of	IN
cord-264884-ydkigome	634	10	phage	phage	NN
cord-264884-ydkigome	634	11	evolution	evolution	NN
cord-264884-ydkigome	634	12	as	as	IN
cord-264884-ydkigome	634	13	presented	present	VBN
cord-264884-ydkigome	634	14	above	above	RB
cord-264884-ydkigome	634	15	has	have	VBZ
cord-264884-ydkigome	634	16	a	a	DT
cord-264884-ydkigome	634	17	direct	direct	JJ
cord-264884-ydkigome	634	18	conduit	conduit	NN
cord-264884-ydkigome	634	19	into	into	IN
cord-264884-ydkigome	634	20	the	the	DT
cord-264884-ydkigome	634	21	genetic	genetic	JJ
cord-264884-ydkigome	634	22	composition	composition	NN
cord-264884-ydkigome	634	23	of	of	IN
cord-264884-ydkigome	634	24	all	all	DT
cord-264884-ydkigome	634	25	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	634	26	via	via	IN
cord-264884-ydkigome	634	27	lysogeny	lysogeny	NNP
cord-264884-ydkigome	634	28	.	.	.
cord-264884-ydkigome	635	1	The	the	DT
cord-264884-ydkigome	635	2	fi	fi	NN
cord-264884-ydkigome	635	3	tness	tness	NN
cord-264884-ydkigome	635	4	and	and	CC
cord-264884-ydkigome	635	5	evolutionary	evolutionary	JJ
cord-264884-ydkigome	635	6	consequences	consequence	NNS
cord-264884-ydkigome	635	7	of	of	IN
cord-264884-ydkigome	635	8	such	such	JJ
cord-264884-ydkigome	635	9	colonization	colonization	NN
cord-264884-ydkigome	635	10	to	to	IN
cord-264884-ydkigome	635	11	the	the	DT
cord-264884-ydkigome	635	12	evolution	evolution	NN
cord-264884-ydkigome	635	13	of	of	IN
cord-264884-ydkigome	635	14	the	the	DT
cord-264884-ydkigome	635	15	host	host	NN
cord-264884-ydkigome	635	16	and	and	CC
cord-264884-ydkigome	635	17	its	-PRON-	PRP$
cord-264884-ydkigome	635	18	virus	virus	NN
cord-264884-ydkigome	635	19	should	should	MD
cord-264884-ydkigome	635	20	be	be	VB
cord-264884-ydkigome	635	21	considerable	considerable	JJ
cord-264884-ydkigome	635	22	but	but	CC
cord-264884-ydkigome	635	23	is	be	VBZ
cord-264884-ydkigome	635	24	in	in	IN
cord-264884-ydkigome	635	25	need	need	NN
cord-264884-ydkigome	635	26	of	of	IN
cord-264884-ydkigome	635	27	theoretical	theoretical	JJ
cord-264884-ydkigome	635	28	development	development	NN
cord-264884-ydkigome	635	29	.	.	.
cord-264884-ydkigome	636	1	Fitness	fitness	NN
cord-264884-ydkigome	636	2	of	of	IN
cord-264884-ydkigome	636	3	temperate	temperate	JJ
cord-264884-ydkigome	636	4	phage	phage	NN
cord-264884-ydkigome	636	5	,	,	,
cord-264884-ydkigome	636	6	however	however	RB
cord-264884-ydkigome	636	7	,	,	,
cord-264884-ydkigome	636	8	is	be	VBZ
cord-264884-ydkigome	636	9	more	more	RBR
cord-264884-ydkigome	636	10	complicated	complicated	JJ
cord-264884-ydkigome	637	1	then	then	RB
cord-264884-ydkigome	637	2	that	that	DT
cord-264884-ydkigome	637	3	of	of	IN
cord-264884-ydkigome	637	4	a	a	DT
cord-264884-ydkigome	637	5	lytic	lytic	JJ
cord-264884-ydkigome	637	6	virus	virus	NN
cord-264884-ydkigome	637	7	and	and	CC
cord-264884-ydkigome	637	8	,	,	,
cord-264884-ydkigome	637	9	like	like	IN
cord-264884-ydkigome	637	10	fi	fi	XX
cord-264884-ydkigome	637	11	tness	tness	NN
cord-264884-ydkigome	637	12	of	of	IN
cord-264884-ydkigome	637	13	persistence	persistence	NN
cord-264884-ydkigome	637	14	discussed	discuss	VBN
cord-264884-ydkigome	637	15	above	above	RB
cord-264884-ydkigome	637	16	,	,	,
cord-264884-ydkigome	637	17	can	can	MD
cord-264884-ydkigome	637	18	not	not	RB
cord-264884-ydkigome	637	19	be	be	VB
cord-264884-ydkigome	637	20	simply	simply	RB
cord-264884-ydkigome	637	21	described	describe	VBN
cord-264884-ydkigome	637	22	by	by	IN
cord-264884-ydkigome	637	23	relative	relative	JJ
cord-264884-ydkigome	637	24	replication	replication	NN
cord-264884-ydkigome	637	25	or	or	CC
cord-264884-ydkigome	637	26	effi	effi	NNP
cord-264884-ydkigome	637	27	cient	cient	NNP
cord-264884-ydkigome	637	28	virion	virion	NN
cord-264884-ydkigome	637	29	production	production	NN
cord-264884-ydkigome	637	30	.	.	.
cord-264884-ydkigome	638	1	Here	here	RB
cord-264884-ydkigome	638	2	too	too	RB
cord-264884-ydkigome	638	3	,	,	,
cord-264884-ydkigome	638	4	successful	successful	JJ
cord-264884-ydkigome	638	5	phage	phage	NN
cord-264884-ydkigome	638	6	colonization	colonization	NN
cord-264884-ydkigome	638	7	must	must	MD
cord-264884-ydkigome	638	8	inherently	inherently	RB
cord-264884-ydkigome	638	9	limit	limit	VB
cord-264884-ydkigome	638	10	the	the	DT
cord-264884-ydkigome	638	11	replication	replication	NN
cord-264884-ydkigome	638	12	of	of	IN
cord-264884-ydkigome	638	13	the	the	DT
cord-264884-ydkigome	638	14	same	same	JJ
cord-264884-ydkigome	638	15	virus	virus	NN
cord-264884-ydkigome	638	16	.	.	.
cord-264884-ydkigome	639	1	Thus	thus	RB
cord-264884-ydkigome	639	2	,	,	,
cord-264884-ydkigome	639	3	a	a	DT
cord-264884-ydkigome	639	4	temperate	temperate	JJ
cord-264884-ydkigome	639	5	lifestyle	lifestyle	NN
cord-264884-ydkigome	639	6	also	also	RB
cord-264884-ydkigome	639	7	requires	require	VBZ
cord-264884-ydkigome	639	8	an	an	DT
cord-264884-ydkigome	639	9	autoinhibitory	autoinhibitory	JJ
cord-264884-ydkigome	639	10	capacity	capacity	NN
cord-264884-ydkigome	639	11	.	.	.
cord-264884-ydkigome	640	1	This	this	DT
cord-264884-ydkigome	640	2	generally	generally	RB
cord-264884-ydkigome	640	3	involves	involve	VBZ
cord-264884-ydkigome	640	4	an	an	DT
cord-264884-ydkigome	640	5	immunity	immunity	NN
cord-264884-ydkigome	640	6	gene	gene	NN
cord-264884-ydkigome	640	7	set	set	NN
cord-264884-ydkigome	640	8	that	that	IN
cord-264884-ydkigome	640	9	not	not	RB
cord-264884-ydkigome	640	10	only	only	RB
cord-264884-ydkigome	640	11	limits	limit	VBZ
cord-264884-ydkigome	640	12	self	self	NN
cord-264884-ydkigome	640	13	-	-	HYPH
cord-264884-ydkigome	640	14	replication	replication	NN
cord-264884-ydkigome	640	15	but	but	CC
cord-264884-ydkigome	640	16	can	can	MD
cord-264884-ydkigome	640	17	also	also	RB
cord-264884-ydkigome	640	18	affect	affect	VB
cord-264884-ydkigome	640	19	replication	replication	NN
cord-264884-ydkigome	640	20	of	of	IN
cord-264884-ydkigome	640	21	other	other	JJ
cord-264884-ydkigome	640	22	temperate	temperate	JJ
cord-264884-ydkigome	640	23	and	and	CC
cord-264884-ydkigome	640	24	lytic	lytic	JJ
cord-264884-ydkigome	640	25	viruses	virus	NNS
cord-264884-ydkigome	640	26	,	,	,
cord-264884-ydkigome	640	27	i.e.	i.e.	FW
cord-264884-ydkigome	640	28	lambda	lambda	NN
cord-264884-ydkigome	640	29	(	(	-LRB-
cord-264884-ydkigome	640	30	even	even	RB
cord-264884-ydkigome	640	31	as	as	IN
cord-264884-ydkigome	640	32	a	a	DT
cord-264884-ydkigome	640	33	defective	defective	JJ
cord-264884-ydkigome	640	34	)	)	-RRB-
cord-264884-ydkigome	640	35	precludes	preclude	VBZ
cord-264884-ydkigome	640	36	T4	T4	NNP
cord-264884-ydkigome	640	37	and	and	CC
cord-264884-ydkigome	640	38	other	other	JJ
cord-264884-ydkigome	640	39	T	t	NN
cord-264884-ydkigome	640	40	-	-	HYPH
cord-264884-ydkigome	640	41	even	even	RB
cord-264884-ydkigome	640	42	phage	phage	NN
cord-264884-ydkigome	640	43	.	.	.
cord-264884-ydkigome	641	1	Uncolonized	uncolonized	JJ
cord-264884-ydkigome	641	2	hosts	host	NNS
cord-264884-ydkigome	641	3	are	be	VBP
cord-264884-ydkigome	641	4	thus	thus	RB
cord-264884-ydkigome	641	5	susceptible	susceptible	JJ
cord-264884-ydkigome	641	6	to	to	IN
cord-264884-ydkigome	641	7	lysis	lysis	NN
cord-264884-ydkigome	641	8	by	by	IN
cord-264884-ydkigome	641	9	highly	highly	RB
cord-264884-ydkigome	641	10	prevalent	prevalent	JJ
cord-264884-ydkigome	641	11	acute	acute	JJ
cord-264884-ydkigome	641	12	tailed	tailed	JJ
cord-264884-ydkigome	641	13	phage	phage	NN
cord-264884-ydkigome	641	14	.	.	.
cord-264884-ydkigome	642	1	Host	host	NN
cord-264884-ydkigome	642	2	fi	fi	IN
cord-264884-ydkigome	642	3	tness	tness	NN
cord-264884-ydkigome	642	4	is	be	VBZ
cord-264884-ydkigome	642	5	thus	thus	RB
cord-264884-ydkigome	642	6	strongly	strongly	RB
cord-264884-ydkigome	642	7	affected	affect	VBN
cord-264884-ydkigome	642	8	by	by	IN
cord-264884-ydkigome	642	9	a	a	DT
cord-264884-ydkigome	642	10	temperate	temperate	JJ
cord-264884-ydkigome	642	11	phage	phage	NN
cord-264884-ydkigome	642	12	due	due	IN
cord-264884-ydkigome	642	13	to	to	IN
cord-264884-ydkigome	642	14	its	-PRON-	PRP$
cord-264884-ydkigome	642	15	ability	ability	NN
cord-264884-ydkigome	642	16	to	to	TO
cord-264884-ydkigome	642	17	preclude	preclude	VB
cord-264884-ydkigome	642	18	and	and	CC
cord-264884-ydkigome	642	19	survive	survive	VB
cord-264884-ydkigome	642	20	other	other	JJ
cord-264884-ydkigome	642	21	competing	compete	VBG
cord-264884-ydkigome	642	22	phage	phage	NN
cord-264884-ydkigome	642	23	.	.	.
cord-264884-ydkigome	643	1	I	-PRON-	PRP
cord-264884-ydkigome	643	2	suggest	suggest	VBP
cord-264884-ydkigome	643	3	this	this	DT
cord-264884-ydkigome	643	4	situation	situation	NN
cord-264884-ydkigome	643	5	is	be	VBZ
cord-264884-ydkigome	643	6	similar	similar	JJ
cord-264884-ydkigome	643	7	to	to	IN
cord-264884-ydkigome	643	8	the	the	DT
cord-264884-ydkigome	643	9	MHV	MHV	NNP
cord-264884-ydkigome	643	10	-	-	HYPH
cord-264884-ydkigome	643	11	mouse	mouse	NN
cord-264884-ydkigome	643	12	exemplar	exemplar	NN
cord-264884-ydkigome	643	13	above	above	RB
cord-264884-ydkigome	643	14	,	,	,
cord-264884-ydkigome	643	15	in	in	IN
cord-264884-ydkigome	643	16	that	that	DT
cord-264884-ydkigome	643	17	virus	virus	NN
cord-264884-ydkigome	643	18	-	-	HYPH
cord-264884-ydkigome	643	19	colonized	colonize	VBN
cord-264884-ydkigome	643	20	hosts	host	NNS
cord-264884-ydkigome	643	21	are	be	VBP
cord-264884-ydkigome	643	22	in	in	IN
cord-264884-ydkigome	643	23	a	a	DT
cord-264884-ydkigome	643	24	state	state	NN
cord-264884-ydkigome	643	25	of	of	IN
cord-264884-ydkigome	643	26	"	"	``
cord-264884-ydkigome	643	27	virus	virus	NN
cord-264884-ydkigome	643	28	addiction	addiction	NN
cord-264884-ydkigome	643	29	"	"	''
cord-264884-ydkigome	643	30	in	in	IN
cord-264884-ydkigome	643	31	which	which	WDT
cord-264884-ydkigome	643	32	persistence	persistence	NN
cord-264884-ydkigome	643	33	is	be	VBZ
cord-264884-ydkigome	643	34	needed	need	VBN
cord-264884-ydkigome	643	35	to	to	TO
cord-264884-ydkigome	643	36	provide	provide	VB
cord-264884-ydkigome	643	37	protection	protection	NN
cord-264884-ydkigome	643	38	from	from	IN
cord-264884-ydkigome	643	39	the	the	DT
cord-264884-ydkigome	643	40	same	same	JJ
cord-264884-ydkigome	643	41	or	or	CC
cord-264884-ydkigome	643	42	similar	similar	JJ
cord-264884-ydkigome	643	43	virus	virus	NN
cord-264884-ydkigome	643	44	(	(	-LRB-
cord-264884-ydkigome	643	45	Villarreal	Villarreal	NNP
cord-264884-ydkigome	643	46	,	,	,
cord-264884-ydkigome	643	47	2005	2005	CD
cord-264884-ydkigome	644	1	(	(	-LRB-
cord-264884-ydkigome	644	2	Villarreal	Villarreal	NNP
cord-264884-ydkigome	644	3	,	,	,
cord-264884-ydkigome	644	4	,	,	,
cord-264884-ydkigome	644	5	2006	2006	CD
cord-264884-ydkigome	644	6	.	.	.
cord-264884-ydkigome	645	1	It	-PRON-	PRP
cord-264884-ydkigome	645	2	is	be	VBZ
cord-264884-ydkigome	645	3	well	well	RB
cord-264884-ydkigome	645	4	established	establish	VBN
cord-264884-ydkigome	645	5	that	that	IN
cord-264884-ydkigome	645	6	most	most	JJS
cord-264884-ydkigome	645	7	natural	natural	JJ
cord-264884-ydkigome	645	8	populations	population	NNS
cord-264884-ydkigome	645	9	of	of	IN
cord-264884-ydkigome	645	10	bacteria	bacteria	NNS
cord-264884-ydkigome	645	11	have	have	VBP
cord-264884-ydkigome	645	12	specifi	specifi	VBN
cord-264884-ydkigome	645	13	c	c	NN
cord-264884-ydkigome	645	14	patterns	pattern	NNS
cord-264884-ydkigome	645	15	of	of	IN
cord-264884-ydkigome	645	16	phage	phage	NN
cord-264884-ydkigome	645	17	colonization	colonization	NN
cord-264884-ydkigome	645	18	,	,	,
cord-264884-ydkigome	645	19	hence	hence	RB
cord-264884-ydkigome	645	20	the	the	DT
cord-264884-ydkigome	645	21	utility	utility	NN
cord-264884-ydkigome	645	22	of	of	IN
cord-264884-ydkigome	645	23	phage	phage	NN
cord-264884-ydkigome	645	24	typing	typing	NN
cord-264884-ydkigome	645	25	for	for	IN
cord-264884-ydkigome	645	26	strain	strain	NN
cord-264884-ydkigome	645	27	identifi	identifi	NNP
cord-264884-ydkigome	645	28	cation	cation	NNP
cord-264884-ydkigome	645	29	.	.	.
cord-264884-ydkigome	646	1	From	from	IN
cord-264884-ydkigome	646	2	this	this	DT
cord-264884-ydkigome	646	3	,	,	,
cord-264884-ydkigome	646	4	we	-PRON-	PRP
cord-264884-ydkigome	646	5	can	can	MD
cord-264884-ydkigome	646	6	infer	infer	VB
cord-264884-ydkigome	646	7	that	that	IN
cord-264884-ydkigome	646	8	virus	virus	NN
cord-264884-ydkigome	646	9	-	-	HYPH
cord-264884-ydkigome	646	10	virus	virus	NN
cord-264884-ydkigome	646	11	competition	competition	NN
cord-264884-ydkigome	646	12	is	be	VBZ
cord-264884-ydkigome	646	13	a	a	DT
cord-264884-ydkigome	646	14	prevalent	prevalent	JJ
cord-264884-ydkigome	646	15	and	and	CC
cord-264884-ydkigome	646	16	major	major	JJ
cord-264884-ydkigome	646	17	issue	issue	NN
cord-264884-ydkigome	646	18	regarding	regard	VBG
cord-264884-ydkigome	646	19	the	the	DT
cord-264884-ydkigome	646	20	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	646	21	fi	fi	NN
cord-264884-ydkigome	646	22	tness	tness	NN
cord-264884-ydkigome	646	23	resulting	result	VBG
cord-264884-ydkigome	646	24	from	from	IN
cord-264884-ydkigome	646	25	a	a	DT
cord-264884-ydkigome	646	26	symbiotic	symbiotic	JJ
cord-264884-ydkigome	646	27	temperate	temperate	JJ
cord-264884-ydkigome	646	28	phage	phage	NN
cord-264884-ydkigome	646	29	-	-	HYPH
cord-264884-ydkigome	646	30	host	host	NN
cord-264884-ydkigome	646	31	combination	combination	NN
cord-264884-ydkigome	646	32	.	.	.
cord-264884-ydkigome	647	1	In	in	IN
cord-264884-ydkigome	647	2	addition	addition	NN
cord-264884-ydkigome	647	3	,	,	,
cord-264884-ydkigome	647	4	such	such	JJ
cord-264884-ydkigome	647	5	virus	virus	NN
cord-264884-ydkigome	647	6	-	-	HYPH
cord-264884-ydkigome	647	7	host	host	NN
cord-264884-ydkigome	647	8	symbiosis	symbiosis	NN
cord-264884-ydkigome	647	9	can	can	MD
cord-264884-ydkigome	647	10	also	also	RB
cord-264884-ydkigome	647	11	affect	affect	VB
cord-264884-ydkigome	647	12	competition	competition	NN
cord-264884-ydkigome	647	13	with	with	IN
cord-264884-ydkigome	647	14	other	other	JJ
cord-264884-ydkigome	647	15	bacteria	bacteria	NNS
cord-264884-ydkigome	647	16	.	.	.
cord-264884-ydkigome	648	1	This	this	DT
cord-264884-ydkigome	648	2	would	would	MD
cord-264884-ydkigome	648	3	be	be	VB
cord-264884-ydkigome	648	4	very	very	RB
cord-264884-ydkigome	648	5	much	much	RB
cord-264884-ydkigome	648	6	like	like	IN
cord-264884-ydkigome	648	7	the	the	DT
cord-264884-ydkigome	648	8	virus	virus	NN
cord-264884-ydkigome	648	9	addiction	addiction	NN
cord-264884-ydkigome	648	10	concept	concept	NN
cord-264884-ydkigome	648	11	outlined	outline	VBN
cord-264884-ydkigome	648	12	above	above	RB
cord-264884-ydkigome	648	13	for	for	IN
cord-264884-ydkigome	648	14	the	the	DT
cord-264884-ydkigome	648	15	MHV	MHV	NNP
cord-264884-ydkigome	648	16	examplar	examplar	JJ
cord-264884-ydkigome	648	17	.	.	.
cord-264884-ydkigome	649	1	The	the	DT
cord-264884-ydkigome	649	2	original	original	JJ
cord-264884-ydkigome	649	3	observation	observation	NN
cord-264884-ydkigome	649	4	of	of	IN
cord-264884-ydkigome	649	5	a	a	DT
cord-264884-ydkigome	649	6	lysogenic	lysogenic	JJ
cord-264884-ydkigome	649	7	process	process	NN
cord-264884-ydkigome	649	8	and	and	CC
cord-264884-ydkigome	649	9	coining	coining	NN
cord-264884-ydkigome	649	10	of	of	IN
cord-264884-ydkigome	649	11	this	this	DT
cord-264884-ydkigome	649	12	term	term	NN
cord-264884-ydkigome	649	13	occurred	occur	VBD
cord-264884-ydkigome	649	14	in	in	IN
cord-264884-ydkigome	649	15	the	the	DT
cord-264884-ydkigome	649	16	1920s	1920	NNS
cord-264884-ydkigome	649	17	when	when	WRB
cord-264884-ydkigome	649	18	two	two	CD
cord-264884-ydkigome	649	19	pure	pure	JJ
cord-264884-ydkigome	649	20	cultures	culture	NNS
cord-264884-ydkigome	649	21	of	of	IN
cord-264884-ydkigome	649	22	bacteria	bacteria	NNS
cord-264884-ydkigome	649	23	were	be	VBD
cord-264884-ydkigome	649	24	grown	grow	VBN
cord-264884-ydkigome	649	25	together	together	RB
cord-264884-ydkigome	649	26	.	.	.
cord-264884-ydkigome	650	1	It	-PRON-	PRP
cord-264884-ydkigome	650	2	was	be	VBD
cord-264884-ydkigome	650	3	observed	observe	VBN
cord-264884-ydkigome	650	4	that	that	IN
cord-264884-ydkigome	650	5	in	in	IN
cord-264884-ydkigome	650	6	some	some	DT
cord-264884-ydkigome	650	7	combinations	combination	NNS
cord-264884-ydkigome	650	8	,	,	,
cord-264884-ydkigome	650	9	one	one	CD
cord-264884-ydkigome	650	10	strain	strain	NN
cord-264884-ydkigome	650	11	would	would	MD
cord-264884-ydkigome	650	12	lyse	lyse	VB
cord-264884-ydkigome	650	13	the	the	DT
cord-264884-ydkigome	650	14	other	other	JJ
cord-264884-ydkigome	650	15	strain	strain	NN
cord-264884-ydkigome	650	16	(	(	-LRB-
cord-264884-ydkigome	650	17	was	be	VBD
cord-264884-ydkigome	650	18	lysogenic	lysogenic	JJ
cord-264884-ydkigome	650	19	)	)	-RRB-
cord-264884-ydkigome	650	20	.	.	.
cord-264884-ydkigome	651	1	Later	later	RB
cord-264884-ydkigome	651	2	,	,	,
cord-264884-ydkigome	651	3	it	-PRON-	PRP
cord-264884-ydkigome	651	4	became	become	VBD
cord-264884-ydkigome	651	5	clear	clear	JJ
cord-264884-ydkigome	651	6	that	that	IN
cord-264884-ydkigome	651	7	such	such	JJ
cord-264884-ydkigome	651	8	lysis	lysis	NN
cord-264884-ydkigome	651	9	was	be	VBD
cord-264884-ydkigome	651	10	mediated	mediate	VBN
cord-264884-ydkigome	651	11	by	by	IN
cord-264884-ydkigome	651	12	reactivation	reactivation	NN
cord-264884-ydkigome	651	13	of	of	IN
cord-264884-ydkigome	651	14	temperate	temperate	JJ
cord-264884-ydkigome	651	15	phage	phage	NN
cord-264884-ydkigome	651	16	present	present	JJ
cord-264884-ydkigome	651	17	in	in	IN
cord-264884-ydkigome	651	18	the	the	DT
cord-264884-ydkigome	651	19	lysogenic	lysogenic	JJ
cord-264884-ydkigome	651	20	strain	strain	NN
cord-264884-ydkigome	651	21	,	,	,
cord-264884-ydkigome	651	22	but	but	CC
cord-264884-ydkigome	651	23	absent	absent	JJ
cord-264884-ydkigome	651	24	from	from	IN
cord-264884-ydkigome	651	25	the	the	DT
cord-264884-ydkigome	651	26	non	non	JJ
cord-264884-ydkigome	651	27	-	-	JJ
cord-264884-ydkigome	651	28	lysogenic	lysogenic	JJ
cord-264884-ydkigome	651	29	susceptible	susceptible	JJ
cord-264884-ydkigome	651	30	strain	strain	NN
cord-264884-ydkigome	651	31	.	.	.
cord-264884-ydkigome	652	1	In	in	IN
cord-264884-ydkigome	652	2	this	this	DT
cord-264884-ydkigome	652	3	relationship	relationship	NN
cord-264884-ydkigome	652	4	,	,	,
cord-264884-ydkigome	652	5	we	-PRON-	PRP
cord-264884-ydkigome	652	6	see	see	VBP
cord-264884-ydkigome	652	7	another	another	DT
cord-264884-ydkigome	652	8	example	example	NN
cord-264884-ydkigome	652	9	of	of	IN
cord-264884-ydkigome	652	10	group	group	NN
cord-264884-ydkigome	652	11	selection	selection	NN
cord-264884-ydkigome	652	12	operating	operate	VBG
cord-264884-ydkigome	652	13	on	on	IN
cord-264884-ydkigome	652	14	bacterial	bacterial	JJ
cord-264884-ydkigome	652	15	populations	population	NNS
cord-264884-ydkigome	652	16	harboring	harbor	VBG
cord-264884-ydkigome	652	17	a	a	DT
cord-264884-ydkigome	652	18	persistent	persistent	JJ
cord-264884-ydkigome	652	19	virus	virus	NN
cord-264884-ydkigome	652	20	.	.	.
cord-264884-ydkigome	653	1	Thus	thus	RB
cord-264884-ydkigome	653	2	,	,	,
cord-264884-ydkigome	653	3	what	what	WDT
cord-264884-ydkigome	653	4	host	host	NN
cord-264884-ydkigome	653	5	is	be	VBZ
cord-264884-ydkigome	653	6	fi	fi	NNP
cord-264884-ydkigome	653	7	t	t	NNP
cord-264884-ydkigome	653	8	depends	depend	VBZ
cord-264884-ydkigome	653	9	very	very	RB
cord-264884-ydkigome	653	10	much	much	RB
cord-264884-ydkigome	653	11	on	on	IN
cord-264884-ydkigome	653	12	the	the	DT
cord-264884-ydkigome	653	13	prevalent	prevalent	JJ
cord-264884-ydkigome	653	14	viruses	virus	NNS
cord-264884-ydkigome	653	15	it	-PRON-	PRP
cord-264884-ydkigome	653	16	will	will	MD
cord-264884-ydkigome	653	17	encounter	encounter	VB
cord-264884-ydkigome	653	18	as	as	RB
cord-264884-ydkigome	653	19	well	well	RB
cord-264884-ydkigome	653	20	as	as	IN
cord-264884-ydkigome	653	21	the	the	DT
cord-264884-ydkigome	653	22	viruses	virus	NNS
cord-264884-ydkigome	653	23	that	that	WDT
cord-264884-ydkigome	653	24	colonize	colonize	VBP
cord-264884-ydkigome	653	25	it	-PRON-	PRP
cord-264884-ydkigome	653	26	.	.	.
cord-264884-ydkigome	654	1	Bacterial	bacterial	JJ
cord-264884-ydkigome	654	2	populations	population	NNS
cord-264884-ydkigome	654	3	that	that	WDT
cord-264884-ydkigome	654	4	are	be	VBP
cord-264884-ydkigome	654	5	colonized	colonize	VBN
cord-264884-ydkigome	654	6	by	by	IN
cord-264884-ydkigome	654	7	the	the	DT
cord-264884-ydkigome	654	8	same	same	JJ
cord-264884-ydkigome	654	9	or	or	CC
cord-264884-ydkigome	654	10	similar	similar	JJ
cord-264884-ydkigome	654	11	phage	phage	NN
cord-264884-ydkigome	654	12	express	express	VBP
cord-264884-ydkigome	654	13	the	the	DT
cord-264884-ydkigome	654	14	appropriate	appropriate	JJ
cord-264884-ydkigome	654	15	immunity	immunity	NN
cord-264884-ydkigome	654	16	functions	function	NNS
cord-264884-ydkigome	654	17	and	and	CC
cord-264884-ydkigome	654	18	are	be	VBP
cord-264884-ydkigome	654	19	protected	protect	VBN
cord-264884-ydkigome	654	20	from	from	IN
cord-264884-ydkigome	654	21	lysis	lysis	NN
cord-264884-ydkigome	654	22	by	by	IN
cord-264884-ydkigome	654	23	the	the	DT
cord-264884-ydkigome	654	24	same	same	JJ
cord-264884-ydkigome	654	25	or	or	CC
cord-264884-ydkigome	654	26	similar	similar	JJ
cord-264884-ydkigome	654	27	phage	phage	NN
cord-264884-ydkigome	654	28	.	.	.
cord-264884-ydkigome	655	1	Such	such	PDT
cord-264884-ydkigome	655	2	a	a	DT
cord-264884-ydkigome	655	3	situation	situation	NN
cord-264884-ydkigome	655	4	has	have	VBZ
cord-264884-ydkigome	655	5	signifi	signifi	NNP
cord-264884-ydkigome	655	6	ca	can	MD
cord-264884-ydkigome	655	7	nt	not	RB
cord-264884-ydkigome	655	8	implication	implication	NN
cord-264884-ydkigome	655	9	for	for	IN
cord-264884-ydkigome	655	10	the	the	DT
cord-264884-ydkigome	655	11	evolution	evolution	NN
cord-264884-ydkigome	655	12	of	of	IN
cord-264884-ydkigome	655	13	immunity	immunity	NN
cord-264884-ydkigome	655	14	and	and	CC
cord-264884-ydkigome	655	15	group	group	NN
cord-264884-ydkigome	655	16	identity	identity	NN
cord-264884-ydkigome	655	17	for	for	IN
cord-264884-ydkigome	655	18	cells	cell	NNS
cord-264884-ydkigome	655	19	.	.	.
cord-264884-ydkigome	656	1	Host	host	NN
cord-264884-ydkigome	656	2	stability	stability	NN
cord-264884-ydkigome	656	3	becomes	become	VBZ
cord-264884-ydkigome	656	4	a	a	DT
cord-264884-ydkigome	656	5	major	major	JJ
cord-264884-ydkigome	656	6	fi	fi	NN
cord-264884-ydkigome	656	7	tness	tness	NN
cord-264884-ydkigome	656	8	issue	issue	NN
cord-264884-ydkigome	656	9	for	for	IN
cord-264884-ydkigome	656	10	a	a	DT
cord-264884-ydkigome	656	11	persistent	persistent	JJ
cord-264884-ydkigome	656	12	virus	virus	NN
cord-264884-ydkigome	656	13	life	life	NN
cord-264884-ydkigome	656	14	strategy	strategy	NN
cord-264884-ydkigome	656	15	.	.	.
cord-264884-ydkigome	657	1	It	-PRON-	PRP
cord-264884-ydkigome	657	2	is	be	VBZ
cord-264884-ydkigome	657	3	generally	generally	RB
cord-264884-ydkigome	657	4	thought	think	VBN
cord-264884-ydkigome	657	5	that	that	IN
cord-264884-ydkigome	657	6	a	a	DT
cord-264884-ydkigome	657	7	temperate	temperate	JJ
cord-264884-ydkigome	657	8	virus	virus	NN
cord-264884-ydkigome	657	9	attains	attain	VBZ
cord-264884-ydkigome	657	10	a	a	DT
cord-264884-ydkigome	657	11	stable	stable	JJ
cord-264884-ydkigome	657	12	colonization	colonization	NN
cord-264884-ydkigome	657	13	of	of	IN
cord-264884-ydkigome	657	14	its	-PRON-	PRP$
cord-264884-ydkigome	657	15	host	host	NN
cord-264884-ydkigome	657	16	by	by	IN
cord-264884-ydkigome	657	17	simply	simply	RB
cord-264884-ydkigome	657	18	integrating	integrate	VBG
cord-264884-ydkigome	657	19	into	into	IN
cord-264884-ydkigome	657	20	and	and	CC
cord-264884-ydkigome	657	21	become	become	VB
cord-264884-ydkigome	657	22	one	one	CD
cord-264884-ydkigome	657	23	with	with	IN
cord-264884-ydkigome	657	24	the	the	DT
cord-264884-ydkigome	657	25	host	host	NN
cord-264884-ydkigome	657	26	genome	genome	NN
cord-264884-ydkigome	657	27	.	.	.
cord-264884-ydkigome	658	1	However	however	RB
cord-264884-ydkigome	658	2	,	,	,
cord-264884-ydkigome	658	3	there	there	EX
cord-264884-ydkigome	658	4	are	be	VBP
cord-264884-ydkigome	658	5	also	also	RB
cord-264884-ydkigome	658	6	clear	clear	JJ
cord-264884-ydkigome	658	7	examples	example	NNS
cord-264884-ydkigome	658	8	of	of	IN
cord-264884-ydkigome	658	9	stable	stable	JJ
cord-264884-ydkigome	658	10	phage	phage	NN
cord-264884-ydkigome	658	11	persistence	persistence	NN
cord-264884-ydkigome	658	12	that	that	WDT
cord-264884-ydkigome	658	13	does	do	VBZ
cord-264884-ydkigome	658	14	not	not	RB
cord-264884-ydkigome	658	15	integrate	integrate	VB
cord-264884-ydkigome	658	16	and	and	CC
cord-264884-ydkigome	658	17	uses	use	VBZ
cord-264884-ydkigome	658	18	other	other	JJ
cord-264884-ydkigome	658	19	strategies	strategy	NNS
cord-264884-ydkigome	658	20	to	to	TO
cord-264884-ydkigome	658	21	attain	attain	VB
cord-264884-ydkigome	658	22	host	host	NN
cord-264884-ydkigome	658	23	stability	stability	NN
cord-264884-ydkigome	658	24	(	(	-LRB-
cord-264884-ydkigome	658	25	similar	similar	JJ
cord-264884-ydkigome	658	26	to	to	IN
cord-264884-ydkigome	658	27	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	658	28	DNA	dna	NN
cord-264884-ydkigome	658	29	viruses	virus	NNS
cord-264884-ydkigome	658	30	;	;	:
cord-264884-ydkigome	658	31	see	see	VB
cord-264884-ydkigome	658	32	below	below	RB
cord-264884-ydkigome	658	33	for	for	IN
cord-264884-ydkigome	658	34	the	the	DT
cord-264884-ydkigome	658	35	P1	P1	NNP
cord-264884-ydkigome	658	36	phage	phage	NN
cord-264884-ydkigome	658	37	exemplar	exemplar	NN
cord-264884-ydkigome	658	38	of	of	IN
cord-264884-ydkigome	658	39	this	this	DT
cord-264884-ydkigome	658	40	)	)	-RRB-
cord-264884-ydkigome	658	41	.	.	.
cord-264884-ydkigome	659	1	Like	like	IN
cord-264884-ydkigome	659	2	a	a	DT
cord-264884-ydkigome	659	3	temperate	temperate	JJ
cord-264884-ydkigome	659	4	phage	phage	NN
cord-264884-ydkigome	659	5	,	,	,
cord-264884-ydkigome	659	6	a	a	DT
cord-264884-ydkigome	659	7	host	host	NN
cord-264884-ydkigome	659	8	that	that	WDT
cord-264884-ydkigome	659	9	is	be	VBZ
cord-264884-ydkigome	659	10	colonized	colonize	VBN
cord-264884-ydkigome	659	11	by	by	IN
cord-264884-ydkigome	659	12	episomal	episomal	JJ
cord-264884-ydkigome	659	13	persisting	persist	VBG
cord-264884-ydkigome	659	14	viruses	virus	NNS
cord-264884-ydkigome	659	15	has	have	VBZ
cord-264884-ydkigome	659	16	also	also	RB
cord-264884-ydkigome	659	17	been	be	VBN
cord-264884-ydkigome	659	18	much	much	RB
cord-264884-ydkigome	659	19	affected	affect	VBN
cord-264884-ydkigome	659	20	in	in	IN
cord-264884-ydkigome	659	21	its	-PRON-	PRP$
cord-264884-ydkigome	659	22	evolutionary	evolutionary	JJ
cord-264884-ydkigome	659	23	potential	potential	NN
cord-264884-ydkigome	659	24	.	.	.
cord-264884-ydkigome	660	1	It	-PRON-	PRP
cord-264884-ydkigome	660	2	is	be	VBZ
cord-264884-ydkigome	660	3	clear	clear	JJ
cord-264884-ydkigome	660	4	that	that	IN
cord-264884-ydkigome	660	5	phage	phage	NN
cord-264884-ydkigome	660	6	can	can	MD
cord-264884-ydkigome	660	7	have	have	VB
cord-264884-ydkigome	660	8	complex	complex	JJ
cord-264884-ydkigome	660	9	effects	effect	NNS
cord-264884-ydkigome	660	10	on	on	IN
cord-264884-ydkigome	660	11	host	host	NN
cord-264884-ydkigome	660	12	populations	population	NNS
cord-264884-ydkigome	660	13	,	,	,
cord-264884-ydkigome	660	14	but	but	CC
cord-264884-ydkigome	660	15	these	these	DT
cord-264884-ydkigome	660	16	phage	phage	NN
cord-264884-ydkigome	660	17	themselves	-PRON-	PRP
cord-264884-ydkigome	660	18	often	often	RB
cord-264884-ydkigome	660	19	exist	exist	VBP
cord-264884-ydkigome	660	20	in	in	IN
cord-264884-ydkigome	660	21	complex	complex	JJ
cord-264884-ydkigome	660	22	and	and	CC
cord-264884-ydkigome	660	23	mixed	mixed	JJ
cord-264884-ydkigome	660	24	states	state	NNS
cord-264884-ydkigome	660	25	that	that	WDT
cord-264884-ydkigome	660	26	can	can	MD
cord-264884-ydkigome	660	27	be	be	VB
cord-264884-ydkigome	660	28	diffi	diffi	JJ
cord-264884-ydkigome	660	29	cult	cult	NN
cord-264884-ydkigome	660	30	to	to	TO
cord-264884-ydkigome	660	31	unravel	unravel	VB
cord-264884-ydkigome	660	32	(	(	-LRB-
cord-264884-ydkigome	660	33	Harcombe	Harcombe	NNP
cord-264884-ydkigome	660	34	and	and	CC
cord-264884-ydkigome	660	35	Bull	Bull	NNP
cord-264884-ydkigome	660	36	,	,	,
cord-264884-ydkigome	660	37	2005	2005	CD
cord-264884-ydkigome	660	38	)	)	-RRB-
cord-264884-ydkigome	660	39	.	.	.
cord-264884-ydkigome	661	1	It	-PRON-	PRP
cord-264884-ydkigome	661	2	has	have	VBZ
cord-264884-ydkigome	661	3	been	be	VBN
cord-264884-ydkigome	661	4	known	know	VBN
cord-264884-ydkigome	661	5	for	for	IN
cord-264884-ydkigome	661	6	some	some	DT
cord-264884-ydkigome	661	7	time	time	NN
cord-264884-ydkigome	661	8	that	that	WDT
cord-264884-ydkigome	661	9	the	the	DT
cord-264884-ydkigome	661	10	presence	presence	NN
cord-264884-ydkigome	661	11	of	of	IN
cord-264884-ydkigome	661	12	otherwise	otherwise	RB
cord-264884-ydkigome	661	13	silent	silent	JJ
cord-264884-ydkigome	661	14	phage	phage	NN
cord-264884-ydkigome	661	15	can	can	MD
cord-264884-ydkigome	661	16	greatly	greatly	RB
cord-264884-ydkigome	661	17	affect	affect	VB
cord-264884-ydkigome	661	18	the	the	DT
cord-264884-ydkigome	661	19	growth	growth	NN
cord-264884-ydkigome	661	20	of	of	IN
cord-264884-ydkigome	661	21	other	other	JJ
cord-264884-ydkigome	661	22	virus	virus	NN
cord-264884-ydkigome	661	23	and	and	CC
cord-264884-ydkigome	661	24	susceptibility	susceptibility	NN
cord-264884-ydkigome	661	25	of	of	IN
cord-264884-ydkigome	661	26	host	host	NN
cord-264884-ydkigome	661	27	.	.	.
cord-264884-ydkigome	662	1	One	one	CD
cord-264884-ydkigome	662	2	such	such	JJ
cord-264884-ydkigome	662	3	silent	silent	JJ
cord-264884-ydkigome	662	4	and	and	CC
cord-264884-ydkigome	662	5	common	common	JJ
cord-264884-ydkigome	662	6	phage	phage	NN
cord-264884-ydkigome	662	7	that	that	WDT
cord-264884-ydkigome	662	8	has	have	VBZ
cord-264884-ydkigome	662	9	long	long	RB
cord-264884-ydkigome	662	10	been	be	VBN
cord-264884-ydkigome	662	11	studied	study	VBN
cord-264884-ydkigome	662	12	is	be	VBZ
cord-264884-ydkigome	662	13	P1	P1	NNP
cord-264884-ydkigome	662	14	.	.	.
cord-264884-ydkigome	663	1	P1	P1	NNP
cord-264884-ydkigome	663	2	was	be	VBD
cord-264884-ydkigome	663	3	initially	initially	RB
cord-264884-ydkigome	663	4	discovered	discover	VBN
cord-264884-ydkigome	663	5	due	due	IN
cord-264884-ydkigome	663	6	to	to	IN
cord-264884-ydkigome	663	7	its	-PRON-	PRP$
cord-264884-ydkigome	663	8	effect	effect	NN
cord-264884-ydkigome	663	9	on	on	IN
cord-264884-ydkigome	663	10	T4	T4	NNP
cord-264884-ydkigome	663	11	and	and	CC
cord-264884-ydkigome	663	12	lambda	lambda	NN
cord-264884-ydkigome	663	13	.	.	.
cord-264884-ydkigome	664	1	However	however	RB
cord-264884-ydkigome	664	2	,	,	,
cord-264884-ydkigome	664	3	P1	P1	NNP
cord-264884-ydkigome	664	4	has	have	VBZ
cord-264884-ydkigome	664	5	been	be	VBN
cord-264884-ydkigome	664	6	a	a	DT
cord-264884-ydkigome	664	7	very	very	RB
cord-264884-ydkigome	664	8	interesting	interesting	JJ
cord-264884-ydkigome	664	9	model	model	NN
cord-264884-ydkigome	664	10	,	,	,
cord-264884-ydkigome	664	11	not	not	RB
cord-264884-ydkigome	664	12	because	because	IN
cord-264884-ydkigome	664	13	it	-PRON-	PRP
cord-264884-ydkigome	664	14	causes	cause	VBZ
cord-264884-ydkigome	664	15	disease	disease	NN
cord-264884-ydkigome	664	16	or	or	CC
cord-264884-ydkigome	664	17	offers	offer	VBZ
cord-264884-ydkigome	664	18	potential	potential	JJ
cord-264884-ydkigome	664	19	therapy	therapy	NN
cord-264884-ydkigome	664	20	against	against	IN
cord-264884-ydkigome	664	21	bacterial	bacterial	JJ
cord-264884-ydkigome	664	22	pathogens	pathogen	NNS
cord-264884-ydkigome	664	23	,	,	,
cord-264884-ydkigome	664	24	but	but	CC
cord-264884-ydkigome	664	25	simply	simply	RB
cord-264884-ydkigome	664	26	because	because	IN
cord-264884-ydkigome	664	27	it	-PRON-	PRP
cord-264884-ydkigome	664	28	persists	persist	VBZ
cord-264884-ydkigome	664	29	effi	effi	NNP
cord-264884-ydkigome	664	30	ciently	ciently	NNP
cord-264884-ydkigome	664	31	as	as	IN
cord-264884-ydkigome	664	32	an	an	DT
cord-264884-ydkigome	664	33	episome	episome	NN
cord-264884-ydkigome	664	34	and	and	CC
cord-264884-ydkigome	664	35	competes	compete	VBZ
cord-264884-ydkigome	664	36	effectively	effectively	RB
cord-264884-ydkigome	664	37	with	with	IN
cord-264884-ydkigome	664	38	many	many	JJ
cord-264884-ydkigome	664	39	other	other	JJ
cord-264884-ydkigome	664	40	phage	phage	NN
cord-264884-ydkigome	664	41	(	(	-LRB-
cord-264884-ydkigome	664	42	Yarmolinsky	Yarmolinsky	NNP
cord-264884-ydkigome	664	43	,	,	,
cord-264884-ydkigome	664	44	2004	2004	CD
cord-264884-ydkigome	664	45	)	)	-RRB-
cord-264884-ydkigome	664	46	.	.	.
cord-264884-ydkigome	665	1	Since	since	IN
cord-264884-ydkigome	665	2	it	-PRON-	PRP
cord-264884-ydkigome	665	3	does	do	VBZ
cord-264884-ydkigome	665	4	so	so	RB
cord-264884-ydkigome	665	5	without	without	IN
cord-264884-ydkigome	665	6	integrating	integrate	VBG
cord-264884-ydkigome	665	7	,	,	,
cord-264884-ydkigome	665	8	P1	P1	NNP
cord-264884-ydkigome	665	9	provides	provide	VBZ
cord-264884-ydkigome	665	10	us	-PRON-	PRP
cord-264884-ydkigome	665	11	with	with	IN
cord-264884-ydkigome	665	12	one	one	CD
cord-264884-ydkigome	665	13	of	of	IN
cord-264884-ydkigome	665	14	the	the	DT
cord-264884-ydkigome	665	15	only	only	JJ
cord-264884-ydkigome	665	16	well	well	RB
cord-264884-ydkigome	665	17	-	-	HYPH
cord-264884-ydkigome	665	18	studied	study	VBN
cord-264884-ydkigome	665	19	models	model	NNS
cord-264884-ydkigome	665	20	that	that	WDT
cord-264884-ydkigome	665	21	can	can	MD
cord-264884-ydkigome	665	22	inform	inform	VB
cord-264884-ydkigome	665	23	us	-PRON-	PRP
cord-264884-ydkigome	665	24	regarding	regard	VBG
cord-264884-ydkigome	665	25	the	the	DT
cord-264884-ydkigome	665	26	molecular	molecular	JJ
cord-264884-ydkigome	665	27	strategies	strategy	NNS
cord-264884-ydkigome	665	28	and	and	CC
cord-264884-ydkigome	665	29	details	detail	NNS
cord-264884-ydkigome	665	30	of	of	IN
cord-264884-ydkigome	665	31	how	how	WRB
cord-264884-ydkigome	665	32	stability	stability	NN
cord-264884-ydkigome	665	33	in	in	IN
cord-264884-ydkigome	665	34	non	non	JJ
cord-264884-ydkigome	665	35	-	-	JJ
cord-264884-ydkigome	665	36	genomic	genomic	JJ
cord-264884-ydkigome	665	37	persistence	persistence	NN
cord-264884-ydkigome	665	38	is	be	VBZ
cord-264884-ydkigome	665	39	attained	attain	VBN
cord-264884-ydkigome	665	40	.	.	.
cord-264884-ydkigome	666	1	Curiously	curiously	RB
cord-264884-ydkigome	666	2	,	,	,
cord-264884-ydkigome	666	3	a	a	DT
cord-264884-ydkigome	666	4	main	main	JJ
cord-264884-ydkigome	666	5	strategy	strategy	NN
cord-264884-ydkigome	666	6	by	by	IN
cord-264884-ydkigome	666	7	which	which	WDT
cord-264884-ydkigome	666	8	P1	P1	NNP
cord-264884-ydkigome	666	9	attains	attain	VBZ
cord-264884-ydkigome	666	10	this	this	DT
cord-264884-ydkigome	666	11	stability	stability	NN
cord-264884-ydkigome	666	12	was	be	VBD
cord-264884-ydkigome	666	13	inapparent	inapparent	JJ
cord-264884-ydkigome	666	14	and	and	CC
cord-264884-ydkigome	666	15	not	not	RB
cord-264884-ydkigome	666	16	suspected	suspect	VBN
cord-264884-ydkigome	666	17	after	after	IN
cord-264884-ydkigome	666	18	several	several	JJ
cord-264884-ydkigome	666	19	decades	decade	NNS
cord-264884-ydkigome	666	20	of	of	IN
cord-264884-ydkigome	666	21	study	study	NN
cord-264884-ydkigome	666	22	.	.	.
cord-264884-ydkigome	667	1	It	-PRON-	PRP
cord-264884-ydkigome	667	2	became	become	VBD
cord-264884-ydkigome	667	3	apparent	apparent	JJ
cord-264884-ydkigome	667	4	only	only	RB
cord-264884-ydkigome	667	5	after	after	IN
cord-264884-ydkigome	667	6	replication	replication	NN
cord-264884-ydkigome	667	7	mutations	mutation	NNS
cord-264884-ydkigome	667	8	were	be	VBD
cord-264884-ydkigome	667	9	made	make	VBN
cord-264884-ydkigome	667	10	that	that	IN
cord-264884-ydkigome	667	11	induced	induce	VBN
cord-264884-ydkigome	667	12	self	self	NN
cord-264884-ydkigome	667	13	-	-	HYPH
cord-264884-ydkigome	667	14	destruction	destruction	NN
cord-264884-ydkigome	667	15	and	and	CC
cord-264884-ydkigome	667	16	uncovered	uncover	VBD
cord-264884-ydkigome	667	17	the	the	DT
cord-264884-ydkigome	667	18	existence	existence	NN
cord-264884-ydkigome	667	19	of	of	IN
cord-264884-ydkigome	667	20	what	what	WP
cord-264884-ydkigome	667	21	came	come	VBD
cord-264884-ydkigome	667	22	to	to	TO
cord-264884-ydkigome	667	23	be	be	VB
cord-264884-ydkigome	667	24	called	call	VBN
cord-264884-ydkigome	667	25	"	"	``
cord-264884-ydkigome	667	26	addiction	addiction	NN
cord-264884-ydkigome	667	27	modules	module	NNS
cord-264884-ydkigome	667	28	"	"	''
cord-264884-ydkigome	668	1	(	(	-LRB-
cord-264884-ydkigome	668	2	Lehnherr	Lehnherr	NNP
cord-264884-ydkigome	668	3	et	et	NNP
cord-264884-ydkigome	668	4	al	al	NNP
cord-264884-ydkigome	668	5	.	.	NNP
cord-264884-ydkigome	668	6	,	,	,
cord-264884-ydkigome	668	7	1993	1993	CD
cord-264884-ydkigome	668	8	)	)	-RRB-
cord-264884-ydkigome	668	9	.	.	.
cord-264884-ydkigome	669	1	P1	P1	NNP
cord-264884-ydkigome	669	2	encodes	encode	VBZ
cord-264884-ydkigome	669	3	several	several	JJ
cord-264884-ydkigome	669	4	gene	gene	NN
cord-264884-ydkigome	669	5	pairs	pair	NNS
cord-264884-ydkigome	669	6	(	(	-LRB-
cord-264884-ydkigome	669	7	toxins/	toxins/	CD
cord-264884-ydkigome	669	8	antitoxins	antitoxin	NNS
cord-264884-ydkigome	669	9	,	,	,
cord-264884-ydkigome	669	10	such	such	JJ
cord-264884-ydkigome	669	11	as	as	IN
cord-264884-ydkigome	669	12	the	the	DT
cord-264884-ydkigome	669	13	PhD	PhD	NNP
cord-264884-ydkigome	669	14	/	/	SYM
cord-264884-ydkigome	669	15	DOC	DOC	NNP
cord-264884-ydkigome	669	16	pair	pair	NN
cord-264884-ydkigome	669	17	)	)	-RRB-
cord-264884-ydkigome	669	18	that	that	WDT
cord-264884-ydkigome	669	19	protect	protect	VBP
cord-264884-ydkigome	669	20	bacteria	bacteria	NNS
cord-264884-ydkigome	669	21	harboring	harbor	VBG
cord-264884-ydkigome	669	22	P1	P1	NNP
cord-264884-ydkigome	669	23	,	,	,
cord-264884-ydkigome	669	24	but	but	CC
cord-264884-ydkigome	669	25	kill	kill	VB
cord-264884-ydkigome	669	26	daughter	daughter	NN
cord-264884-ydkigome	669	27	bacteria	bacteria	NNS
cord-264884-ydkigome	669	28	that	that	WDT
cord-264884-ydkigome	669	29	have	have	VBP
cord-264884-ydkigome	669	30	lost	lose	VBN
cord-264884-ydkigome	669	31	the	the	DT
cord-264884-ydkigome	669	32	P1	P1	NNP
cord-264884-ydkigome	669	33	genome	genome	NN
cord-264884-ydkigome	669	34	(	(	-LRB-
cord-264884-ydkigome	669	35	Gazit	Gazit	NNP
cord-264884-ydkigome	669	36	and	and	CC
cord-264884-ydkigome	669	37	Sauer	Sauer	NNP
cord-264884-ydkigome	669	38	,	,	,
cord-264884-ydkigome	669	39	1999	1999	CD
cord-264884-ydkigome	669	40	)	)	-RRB-
cord-264884-ydkigome	669	41	.	.	.
cord-264884-ydkigome	670	1	This	this	DT
cord-264884-ydkigome	670	2	strategy	strategy	NN
cord-264884-ydkigome	670	3	compels	compel	VBZ
cord-264884-ydkigome	670	4	colonized	colonize	VBN
cord-264884-ydkigome	670	5	E.	E.	NNP
cord-264884-ydkigome	670	6	coli	coli	NNS
cord-264884-ydkigome	670	7	to	to	TO
cord-264884-ydkigome	670	8	maintain	maintain	VB
cord-264884-ydkigome	670	9	P1	P1	NNP
cord-264884-ydkigome	670	10	or	or	CC
cord-264884-ydkigome	670	11	die	die	VB
cord-264884-ydkigome	670	12	(	(	-LRB-
cord-264884-ydkigome	670	13	DOC	doc	NN
cord-264884-ydkigome	670	14	,	,	,
cord-264884-ydkigome	670	15	death	death	NN
cord-264884-ydkigome	670	16	on	on	IN
cord-264884-ydkigome	670	17	curing	cure	VBG
cord-264884-ydkigome	670	18	)	)	-RRB-
cord-264884-ydkigome	670	19	.	.	.
cord-264884-ydkigome	671	1	However	however	RB
cord-264884-ydkigome	671	2	,	,	,
cord-264884-ydkigome	671	3	these	these	DT
cord-264884-ydkigome	671	4	very	very	RB
cord-264884-ydkigome	671	5	same	same	JJ
cord-264884-ydkigome	671	6	addiction	addiction	NN
cord-264884-ydkigome	671	7	systems	system	NNS
cord-264884-ydkigome	671	8	are	be	VBP
cord-264884-ydkigome	671	9	also	also	RB
cord-264884-ydkigome	671	10	involved	involve	VBN
cord-264884-ydkigome	671	11	in	in	IN
cord-264884-ydkigome	671	12	protecting	protect	VBG
cord-264884-ydkigome	671	13	a	a	DT
cord-264884-ydkigome	671	14	P1-colonized	p1-colonize	VBN
cord-264884-ydkigome	671	15	colony	colony	NN
cord-264884-ydkigome	671	16	from	from	IN
cord-264884-ydkigome	671	17	T4	T4	NNP
cord-264884-ydkigome	671	18	and	and	CC
cord-264884-ydkigome	671	19	lambda	lambda	NN
cord-264884-ydkigome	671	20	infection	infection	NN
cord-264884-ydkigome	671	21	and	and	CC
cord-264884-ydkigome	671	22	will	will	MD
cord-264884-ydkigome	671	23	also	also	RB
cord-264884-ydkigome	671	24	induce	induce	VB
cord-264884-ydkigome	671	25	self	self	NN
cord-264884-ydkigome	671	26	-	-	HYPH
cord-264884-ydkigome	671	27	destruction	destruction	NN
cord-264884-ydkigome	671	28	when	when	WRB
cord-264884-ydkigome	671	29	cells	cell	NNS
cord-264884-ydkigome	671	30	are	be	VBP
cord-264884-ydkigome	671	31	infected	infect	VBN
cord-264884-ydkigome	671	32	by	by	IN
cord-264884-ydkigome	671	33	those	those	DT
cord-264884-ydkigome	671	34	viruses	virus	NNS
cord-264884-ydkigome	671	35	,	,	,
cord-264884-ydkigome	671	36	protecting	protect	VBG
cord-264884-ydkigome	671	37	the	the	DT
cord-264884-ydkigome	671	38	colony	colony	NN
cord-264884-ydkigome	671	39	(	(	-LRB-
cord-264884-ydkigome	671	40	population	population	NN
cord-264884-ydkigome	671	41	)	)	-RRB-
cord-264884-ydkigome	671	42	.	.	.
cord-264884-ydkigome	672	1	P1	P1	NNP
cord-264884-ydkigome	672	2	also	also	RB
cord-264884-ydkigome	672	3	provides	provide	VBZ
cord-264884-ydkigome	672	4	an	an	DT
cord-264884-ydkigome	672	5	exquisite	exquisite	JJ
cord-264884-ydkigome	672	6	level	level	NN
cord-264884-ydkigome	672	7	of	of	IN
cord-264884-ydkigome	672	8	molecular	molecular	JJ
cord-264884-ydkigome	672	9	self	self	NN
cord-264884-ydkigome	672	10	-	-	HYPH
cord-264884-ydkigome	672	11	identifi	identifi	NNP
cord-264884-ydkigome	672	12	cation	cation	NN
cord-264884-ydkigome	672	13	in	in	IN
cord-264884-ydkigome	672	14	that	that	IN
cord-264884-ydkigome	672	15	it	-PRON-	PRP
cord-264884-ydkigome	672	16	will	will	MD
cord-264884-ydkigome	672	17	recognize	recognize	VB
cord-264884-ydkigome	672	18	a	a	DT
cord-264884-ydkigome	672	19	single	single	JJ
cord-264884-ydkigome	672	20	second	second	JJ
cord-264884-ydkigome	672	21	copy	copy	NN
cord-264884-ydkigome	672	22	of	of	IN
cord-264884-ydkigome	672	23	its	-PRON-	PRP$
cord-264884-ydkigome	672	24	own	own	JJ
cord-264884-ydkigome	672	25	genome	genome	NN
cord-264884-ydkigome	672	26	(	(	-LRB-
cord-264884-ydkigome	672	27	Yarmolinsky	Yarmolinsky	NNP
cord-264884-ydkigome	672	28	,	,	,
cord-264884-ydkigome	672	29	2000	2000	CD
cord-264884-ydkigome	672	30	)	)	-RRB-
cord-264884-ydkigome	672	31	.	.	.
cord-264884-ydkigome	673	1	What	what	WP
cord-264884-ydkigome	673	2	then	then	RB
cord-264884-ydkigome	673	3	is	be	VBZ
cord-264884-ydkigome	673	4	the	the	DT
cord-264884-ydkigome	673	5	fi	fi	XX
cord-264884-ydkigome	673	6	tness	tness	NN
cord-264884-ydkigome	673	7	and	and	CC
cord-264884-ydkigome	673	8	evolutionary	evolutionary	JJ
cord-264884-ydkigome	673	9	consequence	consequence	NN
cord-264884-ydkigome	673	10	to	to	IN
cord-264884-ydkigome	673	11	E.	E.	NNP
cord-264884-ydkigome	673	12	coli	coli	NNS
cord-264884-ydkigome	673	13	harboring	harbor	VBG
cord-264884-ydkigome	673	14	P1	P1	NNP
cord-264884-ydkigome	673	15	?	?	.
cord-264884-ydkigome	674	1	Clearly	clearly	RB
cord-264884-ydkigome	674	2	it	-PRON-	PRP
cord-264884-ydkigome	674	3	is	be	VBZ
cord-264884-ydkigome	674	4	major	major	JJ
cord-264884-ydkigome	674	5	,	,	,
cord-264884-ydkigome	674	6	but	but	CC
cord-264884-ydkigome	674	7	mostly	mostly	RB
cord-264884-ydkigome	674	8	host	host	NN
cord-264884-ydkigome	674	9	fi	fi	NN
cord-264884-ydkigome	674	10	tness	tness	NNP
cord-264884-ydkigome	674	11	is	be	VBZ
cord-264884-ydkigome	674	12	affected	affect	VBN
cord-264884-ydkigome	674	13	relative	relative	JJ
cord-264884-ydkigome	674	14	to	to	IN
cord-264884-ydkigome	674	15	other	other	JJ
cord-264884-ydkigome	674	16	viruses	virus	NNS
cord-264884-ydkigome	674	17	.	.	.
cord-264884-ydkigome	675	1	Accordingly	accordingly	RB
cord-264884-ydkigome	675	2	,	,	,
cord-264884-ydkigome	675	3	when	when	WRB
cord-264884-ydkigome	675	4	contemplating	contemplate	VBG
cord-264884-ydkigome	675	5	the	the	DT
cord-264884-ydkigome	675	6	amazing	amazing	JJ
cord-264884-ydkigome	675	7	complexity	complexity	NN
cord-264884-ydkigome	675	8	of	of	IN
cord-264884-ydkigome	675	9	the	the	DT
cord-264884-ydkigome	675	10	P1	P1	NNP
cord-264884-ydkigome	675	11	immunity	immunity	NN
cord-264884-ydkigome	675	12	and	and	CC
cord-264884-ydkigome	675	13	how	how	WRB
cord-264884-ydkigome	675	14	it	-PRON-	PRP
cord-264884-ydkigome	675	15	evolved	evolve	VBD
cord-264884-ydkigome	675	16	,	,	,
cord-264884-ydkigome	675	17	Yarmolinsky	Yarmolinsky	NNP
cord-264884-ydkigome	675	18	posed	pose	VBD
cord-264884-ydkigome	675	19	the	the	DT
cord-264884-ydkigome	675	20	question	question	NN
cord-264884-ydkigome	675	21	;	;	:
cord-264884-ydkigome	675	22	"	"	``
cord-264884-ydkigome	675	23	Could	Could	MD
cord-264884-ydkigome	675	24	the	the	DT
cord-264884-ydkigome	675	25	byzantine	byzantine	JJ
cord-264884-ydkigome	675	26	complexity	complexity	NN
cord-264884-ydkigome	675	27	of	of	IN
cord-264884-ydkigome	675	28	the	the	DT
cord-264884-ydkigome	675	29	controls	control	NNS
cord-264884-ydkigome	675	30	at	at	IN
cord-264884-ydkigome	675	31	ImmI	ImmI	NNP
cord-264884-ydkigome	675	32	be	be	VB
cord-264884-ydkigome	675	33	the	the	DT
cord-264884-ydkigome	675	34	outcome	outcome	NN
cord-264884-ydkigome	675	35	,	,	,
cord-264884-ydkigome	675	36	not	not	RB
cord-264884-ydkigome	675	37	of	of	IN
cord-264884-ydkigome	675	38	successive	successive	JJ
cord-264884-ydkigome	675	39	host	host	NN
cord-264884-ydkigome	675	40	-	-	HYPH
cord-264884-ydkigome	675	41	parasite	parasite	NN
cord-264884-ydkigome	675	42	accommodations	accommodation	NNS
cord-264884-ydkigome	675	43	,	,	,
cord-264884-ydkigome	675	44	but	but	CC
cord-264884-ydkigome	675	45	of	of	IN
cord-264884-ydkigome	675	46	competition	competition	NN
cord-264884-ydkigome	675	47	among	among	IN
cord-264884-ydkigome	675	48	related	related	JJ
cord-264884-ydkigome	675	49	phages	phage	NNS
cord-264884-ydkigome	675	50	?	?	.
cord-264884-ydkigome	675	51	"	"	''
cord-264884-ydkigome	676	1	(	(	-LRB-
cord-264884-ydkigome	676	2	Yarmolinsky	Yarmolinsky	NNP
cord-264884-ydkigome	676	3	,	,	,
cord-264884-ydkigome	676	4	2004	2004	CD
cord-264884-ydkigome	676	5	)	)	-RRB-
cord-264884-ydkigome	676	6	.	.	.
cord-264884-ydkigome	677	1	If	if	IN
cord-264884-ydkigome	677	2	we	-PRON-	PRP
cord-264884-ydkigome	677	3	answer	answer	VBP
cord-264884-ydkigome	677	4	yes	yes	UH
cord-264884-ydkigome	677	5	to	to	IN
cord-264884-ydkigome	677	6	this	this	DT
cord-264884-ydkigome	677	7	question	question	NN
cord-264884-ydkigome	677	8	,	,	,
cord-264884-ydkigome	677	9	then	then	RB
cord-264884-ydkigome	677	10	we	-PRON-	PRP
cord-264884-ydkigome	677	11	would	would	MD
cord-264884-ydkigome	677	12	also	also	RB
cord-264884-ydkigome	677	13	conclude	conclude	VB
cord-264884-ydkigome	677	14	that	that	IN
cord-264884-ydkigome	677	15	virus	virus	NN
cord-264884-ydkigome	677	16	-	-	HYPH
cord-264884-ydkigome	677	17	virus	virus	NN
cord-264884-ydkigome	677	18	interactions	interaction	NNS
cord-264884-ydkigome	677	19	and	and	CC
cord-264884-ydkigome	677	20	competition	competition	NN
cord-264884-ydkigome	677	21	in	in	IN
cord-264884-ydkigome	677	22	general	general	JJ
cord-264884-ydkigome	677	23	are	be	VBP
cord-264884-ydkigome	677	24	major	major	JJ
cord-264884-ydkigome	677	25	forces	force	NNS
cord-264884-ydkigome	677	26	in	in	IN
cord-264884-ydkigome	677	27	the	the	DT
cord-264884-ydkigome	677	28	adaptability	adaptability	NN
cord-264884-ydkigome	677	29	and	and	CC
cord-264884-ydkigome	677	30	evolution	evolution	NN
cord-264884-ydkigome	677	31	of	of	IN
cord-264884-ydkigome	677	32	persisting	persist	VBG
cord-264884-ydkigome	677	33	phage	phage	NN
cord-264884-ydkigome	677	34	and	and	CC
cord-264884-ydkigome	677	35	surviving	survive	VBG
cord-264884-ydkigome	677	36	colonized	colonize	VBN
cord-264884-ydkigome	677	37	host	host	NN
cord-264884-ydkigome	677	38	.	.	.
cord-264884-ydkigome	678	1	In	in	IN
cord-264884-ydkigome	678	2	this	this	DT
cord-264884-ydkigome	678	3	light	light	NN
cord-264884-ydkigome	678	4	,	,	,
cord-264884-ydkigome	678	5	viral	viral	JJ
cord-264884-ydkigome	678	6	persistence	persistence	NN
cord-264884-ydkigome	678	7	takes	take	VBZ
cord-264884-ydkigome	678	8	on	on	RP
cord-264884-ydkigome	678	9	a	a	DT
cord-264884-ydkigome	678	10	major	major	JJ
cord-264884-ydkigome	678	11	role	role	NN
cord-264884-ydkigome	678	12	in	in	IN
cord-264884-ydkigome	678	13	virus	virus	NN
cord-264884-ydkigome	678	14	and	and	CC
cord-264884-ydkigome	678	15	host	host	NN
cord-264884-ydkigome	678	16	evolution	evolution	NN
cord-264884-ydkigome	678	17	.	.	.
cord-264884-ydkigome	679	1	The	the	DT
cord-264884-ydkigome	679	2	P1	P1	NNP
cord-264884-ydkigome	679	3	exemplar	exemplar	NN
cord-264884-ydkigome	679	4	has	have	VBZ
cord-264884-ydkigome	679	5	thus	thus	RB
cord-264884-ydkigome	679	6	provided	provide	VBN
cord-264884-ydkigome	679	7	us	-PRON-	PRP
cord-264884-ydkigome	679	8	the	the	DT
cord-264884-ydkigome	679	9	concept	concept	NN
cord-264884-ydkigome	679	10	of	of	IN
cord-264884-ydkigome	679	11	viral	viral	JJ
cord-264884-ydkigome	679	12	addiction	addiction	NN
cord-264884-ydkigome	679	13	that	that	WDT
cord-264884-ydkigome	679	14	also	also	RB
cord-264884-ydkigome	679	15	promotes	promote	VBZ
cord-264884-ydkigome	679	16	host	host	NN
cord-264884-ydkigome	679	17	group	group	NN
cord-264884-ydkigome	679	18	selection	selection	NN
cord-264884-ydkigome	679	19	.	.	.
cord-264884-ydkigome	680	1	Historically	historically	RB
cord-264884-ydkigome	680	2	,	,	,
cord-264884-ydkigome	680	3	we	-PRON-	PRP
cord-264884-ydkigome	680	4	are	be	VBP
cord-264884-ydkigome	680	5	biased	biased	JJ
cord-264884-ydkigome	680	6	to	to	TO
cord-264884-ydkigome	680	7	think	think	VB
cord-264884-ydkigome	680	8	of	of	IN
cord-264884-ydkigome	680	9	viruses	virus	NNS
cord-264884-ydkigome	680	10	(	(	-LRB-
cord-264884-ydkigome	680	11	and	and	CC
cord-264884-ydkigome	680	12	phage	phage	NN
cord-264884-ydkigome	680	13	)	)	-RRB-
cord-264884-ydkigome	680	14	as	as	IN
cord-264884-ydkigome	680	15	agents	agent	NNS
cord-264884-ydkigome	680	16	that	that	WDT
cord-264884-ydkigome	680	17	simply	simply	RB
cord-264884-ydkigome	680	18	kill	kill	VBP
cord-264884-ydkigome	680	19	their	-PRON-	PRP$
cord-264884-ydkigome	680	20	host	host	NN
cord-264884-ydkigome	680	21	.	.	.
cord-264884-ydkigome	681	1	Some	some	DT
cord-264884-ydkigome	681	2	have	have	VBP
cord-264884-ydkigome	681	3	proposed	propose	VBN
cord-264884-ydkigome	681	4	that	that	IN
cord-264884-ydkigome	681	5	the	the	DT
cord-264884-ydkigome	681	6	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	681	7	global	global	JJ
cord-264884-ydkigome	681	8	biomass	biomass	NN
cord-264884-ydkigome	681	9	is	be	VBZ
cord-264884-ydkigome	681	10	phage	phage	NN
cord-264884-ydkigome	681	11	partitioned	partition	VBN
cord-264884-ydkigome	681	12	into	into	IN
cord-264884-ydkigome	681	13	those	those	DT
cord-264884-ydkigome	681	14	populations	population	NNS
cord-264884-ydkigome	681	15	that	that	WDT
cord-264884-ydkigome	681	16	live	live	VBP
cord-264884-ydkigome	681	17	and	and	CC
cord-264884-ydkigome	681	18	those	those	DT
cord-264884-ydkigome	681	19	that	that	WDT
cord-264884-ydkigome	681	20	die	die	VBP
cord-264884-ydkigome	681	21	due	due	JJ
cord-264884-ydkigome	681	22	to	to	IN
cord-264884-ydkigome	681	23	viral	viral	JJ
cord-264884-ydkigome	681	24	lysis	lysis	NN
cord-264884-ydkigome	681	25	.	.	.
cord-264884-ydkigome	682	1	From	from	IN
cord-264884-ydkigome	682	2	such	such	PDT
cord-264884-ydkigome	682	3	a	a	DT
cord-264884-ydkigome	682	4	perspective	perspective	NN
cord-264884-ydkigome	682	5	,	,	,
cord-264884-ydkigome	682	6	viral	viral	JJ
cord-264884-ydkigome	682	7	novelity	novelity	NN
cord-264884-ydkigome	682	8	would	would	MD
cord-264884-ydkigome	682	9	seen	see	VBN
cord-264884-ydkigome	682	10	of	of	IN
cord-264884-ydkigome	682	11	little	little	JJ
cord-264884-ydkigome	682	12	relevance	relevance	NN
cord-264884-ydkigome	682	13	to	to	TO
cord-264884-ydkigome	682	14	host	host	VB
cord-264884-ydkigome	682	15	evolution	evolution	NN
cord-264884-ydkigome	682	16	.	.	.
cord-264884-ydkigome	683	1	Metagenomic	Metagenomic	NNP
cord-264884-ydkigome	683	2	projects	project	NNS
cord-264884-ydkigome	683	3	as	as	IN
cord-264884-ydkigome	683	4	noted	note	VBN
cord-264884-ydkigome	683	5	above	above	RB
cord-264884-ydkigome	683	6	,	,	,
cord-264884-ydkigome	683	7	have	have	VBP
cord-264884-ydkigome	683	8	sequenced	sequence	VBN
cord-264884-ydkigome	683	9	nearly	nearly	RB
cord-264884-ydkigome	683	10	2	2	CD
cord-264884-ydkigome	683	11	million	million	CD
cord-264884-ydkigome	683	12	phage	phage	NN
cord-264884-ydkigome	683	13	genomes	genome	NNS
cord-264884-ydkigome	683	14	and	and	CC
cord-264884-ydkigome	683	15	report	report	VBP
cord-264884-ydkigome	683	16	that	that	IN
cord-264884-ydkigome	683	17	most	most	JJS
cord-264884-ydkigome	683	18	of	of	IN
cord-264884-ydkigome	683	19	these	these	DT
cord-264884-ydkigome	683	20	phage	phage	NN
cord-264884-ydkigome	683	21	genes	gene	NNS
cord-264884-ydkigome	683	22	are	be	VBP
cord-264884-ydkigome	683	23	unique	unique	JJ
cord-264884-ydkigome	683	24	,	,	,
cord-264884-ydkigome	683	25	not	not	RB
cord-264884-ydkigome	683	26	in	in	IN
cord-264884-ydkigome	683	27	the	the	DT
cord-264884-ydkigome	683	28	database	database	NN
cord-264884-ydkigome	683	29	,	,	,
cord-264884-ydkigome	683	30	and	and	CC
cord-264884-ydkigome	683	31	likely	likely	RB
cord-264884-ydkigome	683	32	not	not	RB
cord-264884-ydkigome	683	33	derived	derive	VBN
cord-264884-ydkigome	683	34	from	from	IN
cord-264884-ydkigome	683	35	host	host	NN
cord-264884-ydkigome	683	36	(	(	-LRB-
cord-264884-ydkigome	683	37	Edwards	Edwards	NNP
cord-264884-ydkigome	683	38	and	and	CC
cord-264884-ydkigome	683	39	Rohwer	Rohwer	NNP
cord-264884-ydkigome	683	40	,	,	,
cord-264884-ydkigome	683	41	2005	2005	CD
cord-264884-ydkigome	683	42	)	)	-RRB-
cord-264884-ydkigome	683	43	.	.	.
cord-264884-ydkigome	684	1	The	the	DT
cord-264884-ydkigome	684	2	protein	protein	NN
cord-264884-ydkigome	684	3	repertoire	repertoire	NN
cord-264884-ydkigome	684	4	of	of	IN
cord-264884-ydkigome	684	5	sequenced	sequence	VBN
cord-264884-ydkigome	684	6	phage	phage	NN
cord-264884-ydkigome	684	7	indicates	indicate	VBZ
cord-264884-ydkigome	684	8	that	that	IN
cord-264884-ydkigome	684	9	80	80	CD
cord-264884-ydkigome	684	10	%	%	NN
cord-264884-ydkigome	684	11	of	of	IN
cord-264884-ydkigome	684	12	conserved	conserve	VBN
cord-264884-ydkigome	684	13	phage	phage	NN
cord-264884-ydkigome	684	14	genes	gene	NNS
cord-264884-ydkigome	684	15	are	be	VBP
cord-264884-ydkigome	684	16	specifi	specifi	VBN
cord-264884-ydkigome	684	17	c	c	NN
cord-264884-ydkigome	684	18	to	to	TO
cord-264884-ydkigome	684	19	phage	phage	VB
cord-264884-ydkigome	684	20	and	and	CC
cord-264884-ydkigome	684	21	show	show	VB
cord-264884-ydkigome	684	22	an	an	DT
cord-264884-ydkigome	684	23	evolutionary	evolutionary	JJ
cord-264884-ydkigome	684	24	independence	independence	NN
cord-264884-ydkigome	684	25	from	from	IN
cord-264884-ydkigome	684	26	genes	gene	NNS
cord-264884-ydkigome	684	27	of	of	IN
cord-264884-ydkigome	684	28	host	host	NN
cord-264884-ydkigome	684	29	.	.	.
cord-264884-ydkigome	685	1	This	this	DT
cord-264884-ydkigome	685	2	identifi	identifi	NNP
cord-264884-ydkigome	685	3	es	es	NNP
cord-264884-ydkigome	685	4	a	a	DT
cord-264884-ydkigome	685	5	massive	massive	JJ
cord-264884-ydkigome	685	6	genetic	genetic	JJ
cord-264884-ydkigome	685	7	novelty	novelty	NN
cord-264884-ydkigome	685	8	from	from	IN
cord-264884-ydkigome	685	9	virus	virus	NN
cord-264884-ydkigome	685	10	,	,	,
cord-264884-ydkigome	685	11	which	which	WDT
cord-264884-ydkigome	685	12	is	be	VBZ
cord-264884-ydkigome	685	13	especially	especially	RB
cord-264884-ydkigome	685	14	apparent	apparent	JJ
cord-264884-ydkigome	685	15	in	in	IN
cord-264884-ydkigome	685	16	large	large	JJ
cord-264884-ydkigome	685	17	DNA	dna	NN
cord-264884-ydkigome	685	18	phage	phage	NN
cord-264884-ydkigome	685	19	.	.	.
cord-264884-ydkigome	686	1	As	as	IN
cord-264884-ydkigome	686	2	just	just	RB
cord-264884-ydkigome	686	3	discussed	discuss	VBN
cord-264884-ydkigome	686	4	above	above	RB
cord-264884-ydkigome	686	5	,	,	,
cord-264884-ydkigome	686	6	however	however	RB
cord-264884-ydkigome	686	7	,	,	,
cord-264884-ydkigome	686	8	those	those	DT
cord-264884-ydkigome	686	9	hosts	host	NNS
cord-264884-ydkigome	686	10	that	that	WDT
cord-264884-ydkigome	686	11	live	live	VBP
cord-264884-ydkigome	686	12	are	be	VBP
cord-264884-ydkigome	686	13	also	also	RB
cord-264884-ydkigome	686	14	products	product	NNS
cord-264884-ydkigome	686	15	of	of	IN
cord-264884-ydkigome	686	16	phage	phage	NN
cord-264884-ydkigome	686	17	selection	selection	NN
cord-264884-ydkigome	686	18	,	,	,
cord-264884-ydkigome	686	19	and	and	CC
cord-264884-ydkigome	686	20	persisting	persist	VBG
cord-264884-ydkigome	686	21	temperate	temperate	JJ
cord-264884-ydkigome	686	22	phage	phage	NN
cord-264884-ydkigome	686	23	play	play	VBP
cord-264884-ydkigome	686	24	a	a	DT
cord-264884-ydkigome	686	25	major	major	JJ
cord-264884-ydkigome	686	26	role	role	NN
cord-264884-ydkigome	686	27	in	in	IN
cord-264884-ydkigome	686	28	this	this	DT
cord-264884-ydkigome	686	29	.	.	.
cord-264884-ydkigome	687	1	Such	such	JJ
cord-264884-ydkigome	687	2	phage	phage	NN
cord-264884-ydkigome	687	3	colonization	colonization	NN
cord-264884-ydkigome	687	4	allows	allow	VBZ
cord-264884-ydkigome	687	5	this	this	DT
cord-264884-ydkigome	687	6	massive	massive	JJ
cord-264884-ydkigome	687	7	phage	phage	NN
cord-264884-ydkigome	687	8	novelty	novelty	NN
cord-264884-ydkigome	687	9	to	to	TO
cord-264884-ydkigome	687	10	fi	fi	NNP
cord-264884-ydkigome	687	11	nd	nd	NNP
cord-264884-ydkigome	687	12	its	-PRON-	PRP$
cord-264884-ydkigome	687	13	way	way	NN
cord-264884-ydkigome	687	14	into	into	IN
cord-264884-ydkigome	687	15	host	host	NN
cord-264884-ydkigome	687	16	genomes	genome	NNS
cord-264884-ydkigome	687	17	,	,	,
cord-264884-ydkigome	687	18	which	which	WDT
cord-264884-ydkigome	687	19	allows	allow	VBZ
cord-264884-ydkigome	687	20	viral	viral	JJ
cord-264884-ydkigome	687	21	complex	complex	JJ
cord-264884-ydkigome	687	22	gene	gene	NN
cord-264884-ydkigome	687	23	sets	set	NNS
cord-264884-ydkigome	687	24	to	to	TO
cord-264884-ydkigome	687	25	be	be	VB
cord-264884-ydkigome	687	26	applied	apply	VBN
cord-264884-ydkigome	687	27	to	to	IN
cord-264884-ydkigome	687	28	novel	novel	JJ
cord-264884-ydkigome	687	29	problems	problem	NNS
cord-264884-ydkigome	687	30	of	of	IN
cord-264884-ydkigome	687	31	host	host	NN
cord-264884-ydkigome	687	32	adaptation	adaptation	NN
cord-264884-ydkigome	687	33	.	.	.
cord-264884-ydkigome	688	1	Host	host	NN
cord-264884-ydkigome	688	2	novelty	novelty	NN
cord-264884-ydkigome	688	3	can	can	MD
cord-264884-ydkigome	688	4	thus	thus	RB
cord-264884-ydkigome	688	5	be	be	VB
cord-264884-ydkigome	688	6	introduced	introduce	VBN
cord-264884-ydkigome	688	7	by	by	IN
cord-264884-ydkigome	688	8	phage	phage	NN
cord-264884-ydkigome	688	9	(	(	-LRB-
cord-264884-ydkigome	688	10	Comeau	Comeau	NNP
cord-264884-ydkigome	688	11	and	and	CC
cord-264884-ydkigome	688	12	Krisch	Krisch	NNP
cord-264884-ydkigome	688	13	,	,	,
cord-264884-ydkigome	688	14	2005	2005	CD
cord-264884-ydkigome	688	15	)	)	-RRB-
cord-264884-ydkigome	688	16	.	.	.
cord-264884-ydkigome	689	1	That	that	DT
cord-264884-ydkigome	689	2	persistence	persistence	NN
cord-264884-ydkigome	689	3	is	be	VBZ
cord-264884-ydkigome	689	4	a	a	DT
cord-264884-ydkigome	689	5	major	major	JJ
cord-264884-ydkigome	689	6	life	life	NN
cord-264884-ydkigome	689	7	strategy	strategy	NN
cord-264884-ydkigome	689	8	of	of	IN
cord-264884-ydkigome	689	9	phage	phage	NN
cord-264884-ydkigome	689	10	is	be	VBZ
cord-264884-ydkigome	689	11	confi	confi	NNP
cord-264884-ydkigome	689	12	rmed	rme	VBN
cord-264884-ydkigome	689	13	by	by	IN
cord-264884-ydkigome	689	14	the	the	DT
cord-264884-ydkigome	689	15	large	large	JJ
cord-264884-ydkigome	689	16	numbers	number	NNS
cord-264884-ydkigome	689	17	of	of	IN
cord-264884-ydkigome	689	18	genes	gene	NNS
cord-264884-ydkigome	689	19	associated	associate	VBN
cord-264884-ydkigome	689	20	with	with	IN
cord-264884-ydkigome	689	21	persistence	persistence	NN
cord-264884-ydkigome	689	22	(	(	-LRB-
cord-264884-ydkigome	689	23	i.e.	i.e.	FW
cord-264884-ydkigome	689	24	integrases	integrase	NNS
cord-264884-ydkigome	689	25	,	,	,
cord-264884-ydkigome	689	26	immunity	immunity	NN
cord-264884-ydkigome	689	27	)	)	-RRB-
cord-264884-ydkigome	689	28	observed	observe	VBN
cord-264884-ydkigome	689	29	in	in	IN
cord-264884-ydkigome	689	30	metagenomic	metagenomic	NNP
cord-264884-ydkigome	689	31	screens	screen	NNS
cord-264884-ydkigome	689	32	.	.	.
cord-264884-ydkigome	690	1	There	there	EX
cord-264884-ydkigome	690	2	is	be	VBZ
cord-264884-ydkigome	690	3	also	also	RB
cord-264884-ydkigome	690	4	much	much	JJ
cord-264884-ydkigome	690	5	practical	practical	JJ
cord-264884-ydkigome	690	6	experience	experience	NN
cord-264884-ydkigome	690	7	that	that	WDT
cord-264884-ydkigome	690	8	supports	support	VBZ
cord-264884-ydkigome	690	9	the	the	DT
cord-264884-ydkigome	690	10	crucial	crucial	JJ
cord-264884-ydkigome	690	11	role	role	NN
cord-264884-ydkigome	690	12	of	of	IN
cord-264884-ydkigome	690	13	prophage	prophage	NN
cord-264884-ydkigome	690	14	in	in	IN
cord-264884-ydkigome	690	15	host	host	NN
cord-264884-ydkigome	690	16	evolution	evolution	NN
cord-264884-ydkigome	690	17	.	.	.
cord-264884-ydkigome	691	1	One	one	CD
cord-264884-ydkigome	691	2	particularly	particularly	RB
cord-264884-ydkigome	691	3	well	well	RB
cord-264884-ydkigome	691	4	-	-	HYPH
cord-264884-ydkigome	691	5	studied	study	VBN
cord-264884-ydkigome	691	6	system	system	NN
cord-264884-ydkigome	691	7	that	that	WDT
cord-264884-ydkigome	691	8	has	have	VBZ
cord-264884-ydkigome	691	9	been	be	VBN
cord-264884-ydkigome	691	10	studied	study	VBN
cord-264884-ydkigome	691	11	for	for	IN
cord-264884-ydkigome	691	12	over	over	IN
cord-264884-ydkigome	691	13	50	50	CD
cord-264884-ydkigome	691	14	years	year	NNS
cord-264884-ydkigome	691	15	is	be	VBZ
cord-264884-ydkigome	691	16	the	the	DT
cord-264884-ydkigome	691	17	ongoing	ongoing	JJ
cord-264884-ydkigome	691	18	evaluation	evaluation	NN
cord-264884-ydkigome	691	19	of	of	IN
cord-264884-ydkigome	691	20	phage	phage	NN
cord-264884-ydkigome	691	21	evolution	evolution	NN
cord-264884-ydkigome	691	22	as	as	IN
cord-264884-ydkigome	691	23	observed	observe	VBN
cord-264884-ydkigome	691	24	in	in	IN
cord-264884-ydkigome	691	25	the	the	DT
cord-264884-ydkigome	691	26	dairy	dairy	NN
cord-264884-ydkigome	691	27	industry	industry	NN
cord-264884-ydkigome	692	1	(	(	-LRB-
cord-264884-ydkigome	692	2	Canchaya	Canchaya	NNP
cord-264884-ydkigome	692	3	et	et	NNP
cord-264884-ydkigome	692	4	al	al	NNP
cord-264884-ydkigome	692	5	.	.	.
cord-264884-ydkigome	693	1	,	,	,
cord-264884-ydkigome	693	2	2003	2003	CD
cord-264884-ydkigome	694	1	Brussow	Brussow	NNP
cord-264884-ydkigome	694	2	et	et	NNP
cord-264884-ydkigome	694	3	al	al	NNP
cord-264884-ydkigome	694	4	.	.	NNP
cord-264884-ydkigome	694	5	,	,	,
cord-264884-ydkigome	694	6	2004	2004	CD
cord-264884-ydkigome	694	7	)	)	-RRB-
cord-264884-ydkigome	694	8	.	.	.
cord-264884-ydkigome	695	1	The	the	DT
cord-264884-ydkigome	695	2	temperate	temperate	JJ
cord-264884-ydkigome	695	3	phage	phage	NN
cord-264884-ydkigome	695	4	analysis	analysis	NN
cord-264884-ydkigome	695	5	of	of	IN
cord-264884-ydkigome	695	6	these	these	DT
cord-264884-ydkigome	695	7	bacteria	bacteria	NNS
cord-264884-ydkigome	695	8	follows	follow	VBZ
cord-264884-ydkigome	695	9	a	a	DT
cord-264884-ydkigome	695	10	long	long	JJ
cord-264884-ydkigome	695	11	tradition	tradition	NN
cord-264884-ydkigome	695	12	of	of	IN
cord-264884-ydkigome	695	13	lambda	lambda	NN
cord-264884-ydkigome	695	14	and	and	CC
cord-264884-ydkigome	695	15	E.	E.	NNP
cord-264884-ydkigome	695	16	coli	coli	VBZ
cord-264884-ydkigome	695	17	studies	study	NNS
cord-264884-ydkigome	695	18	(	(	-LRB-
cord-264884-ydkigome	695	19	Campbell	Campbell	NNP
cord-264884-ydkigome	695	20	et	et	NNP
cord-264884-ydkigome	695	21	al	al	NNP
cord-264884-ydkigome	695	22	.	.	.
cord-264884-ydkigome	696	1	,	,	,
cord-264884-ydkigome	696	2	1992	1992	CD
cord-264884-ydkigome	696	3	;	;	:
cord-264884-ydkigome	696	4	Canchaya	Canchaya	NNP
cord-264884-ydkigome	696	5	et	et	NNP
cord-264884-ydkigome	696	6	al	al	NNP
cord-264884-ydkigome	696	7	.	.	NNP
cord-264884-ydkigome	696	8	,	,	,
cord-264884-ydkigome	697	1	2003	2003	CD
cord-264884-ydkigome	698	1	Canchaya	Canchaya	NNP
cord-264884-ydkigome	698	2	et	et	NNP
cord-264884-ydkigome	698	3	al	al	NNP
cord-264884-ydkigome	698	4	.	.	NNP
cord-264884-ydkigome	698	5	,	,	,
cord-264884-ydkigome	698	6	,	,	,
cord-264884-ydkigome	698	7	2004	2004	CD
cord-264884-ydkigome	698	8	.	.	.
cord-264884-ydkigome	699	1	Since	since	IN
cord-264884-ydkigome	699	2	lytic	lytic	JJ
cord-264884-ydkigome	699	3	phage	phage	NN
cord-264884-ydkigome	699	4	can	can	MD
cord-264884-ydkigome	699	5	severely	severely	RB
cord-264884-ydkigome	699	6	disrupt	disrupt	VB
cord-264884-ydkigome	699	7	dairy	dairy	NN
cord-264884-ydkigome	699	8	fermentation	fermentation	NN
cord-264884-ydkigome	699	9	,	,	,
cord-264884-ydkigome	699	10	it	-PRON-	PRP
cord-264884-ydkigome	699	11	was	be	VBD
cord-264884-ydkigome	699	12	of	of	IN
cord-264884-ydkigome	699	13	particular	particular	JJ
cord-264884-ydkigome	699	14	interest	interest	NN
cord-264884-ydkigome	699	15	to	to	TO
cord-264884-ydkigome	699	16	understand	understand	VB
cord-264884-ydkigome	699	17	and	and	CC
cord-264884-ydkigome	699	18	trace	trace	VB
cord-264884-ydkigome	699	19	their	-PRON-	PRP$
cord-264884-ydkigome	699	20	evolution	evolution	NN
cord-264884-ydkigome	699	21	.	.	.
cord-264884-ydkigome	700	1	These	these	DT
cord-264884-ydkigome	700	2	studies	study	NNS
cord-264884-ydkigome	700	3	have	have	VBP
cord-264884-ydkigome	700	4	led	lead	VBN
cord-264884-ydkigome	700	5	Brussow	Brussow	NNP
cord-264884-ydkigome	700	6	to	to	TO
cord-264884-ydkigome	700	7	conclude	conclude	VB
cord-264884-ydkigome	700	8	that	that	IN
cord-264884-ydkigome	700	9	much	much	JJ
cord-264884-ydkigome	700	10	of	of	IN
cord-264884-ydkigome	700	11	the	the	DT
cord-264884-ydkigome	700	12	more	more	RBR
cord-264884-ydkigome	700	13	recent	recent	JJ
cord-264884-ydkigome	700	14	dairy	dairy	NN
cord-264884-ydkigome	700	15	bacteria	bacteria	NNS
cord-264884-ydkigome	700	16	evolution	evolution	NN
cord-264884-ydkigome	700	17	can	can	MD
cord-264884-ydkigome	700	18	be	be	VB
cord-264884-ydkigome	700	19	considered	consider	VBN
cord-264884-ydkigome	700	20	to	to	TO
cord-264884-ydkigome	700	21	have	have	VB
cord-264884-ydkigome	700	22	resulted	result	VBN
cord-264884-ydkigome	700	23	from	from	IN
cord-264884-ydkigome	700	24	the	the	DT
cord-264884-ydkigome	700	25	action	action	NN
cord-264884-ydkigome	700	26	of	of	IN
cord-264884-ydkigome	700	27	temperate	temperate	JJ
cord-264884-ydkigome	700	28	phage	phage	NN
cord-264884-ydkigome	700	29	.	.	.
cord-264884-ydkigome	701	1	A	a	DT
cord-264884-ydkigome	701	2	similar	similar	JJ
cord-264884-ydkigome	701	3	view	view	NN
cord-264884-ydkigome	701	4	applies	apply	VBZ
cord-264884-ydkigome	701	5	to	to	IN
cord-264884-ydkigome	701	6	E.	E.	NNP
cord-264884-ydkigome	701	7	coli	coli	NNS
cord-264884-ydkigome	701	8	and	and	CC
cord-264884-ydkigome	701	9	cyanobacteria	cyanobacteria	NNS
cord-264884-ydkigome	701	10	.	.	.
cord-264884-ydkigome	702	1	In	in	IN
cord-264884-ydkigome	702	2	addition	addition	NN
cord-264884-ydkigome	702	3	,	,	,
cord-264884-ydkigome	702	4	the	the	DT
cord-264884-ydkigome	702	5	ECOR	ECOR	NNP
cord-264884-ydkigome	702	6	collection	collection	NN
cord-264884-ydkigome	702	7	of	of	IN
cord-264884-ydkigome	702	8	72	72	CD
cord-264884-ydkigome	702	9	sequenced	sequence	VBN
cord-264884-ydkigome	702	10	E.	E.	NNP
cord-264884-ydkigome	702	11	coli	coli	NNS
cord-264884-ydkigome	702	12	genomes	genome	NNS
cord-264884-ydkigome	702	13	of	of	IN
cord-264884-ydkigome	702	14	medical	medical	JJ
cord-264884-ydkigome	702	15	interest	interest	NN
cord-264884-ydkigome	702	16	shows	show	VBZ
cord-264884-ydkigome	702	17	that	that	IN
cord-264884-ydkigome	702	18	they	-PRON-	PRP
cord-264884-ydkigome	702	19	differ	differ	VBP
cord-264884-ydkigome	702	20	from	from	IN
cord-264884-ydkigome	702	21	each	each	DT
cord-264884-ydkigome	702	22	other	other	JJ
cord-264884-ydkigome	702	23	mainly	mainly	RB
cord-264884-ydkigome	702	24	due	due	IN
cord-264884-ydkigome	702	25	to	to	IN
cord-264884-ydkigome	702	26	patterns	pattern	NNS
cord-264884-ydkigome	702	27	of	of	IN
cord-264884-ydkigome	702	28	genetic	genetic	JJ
cord-264884-ydkigome	702	29	colonization	colonization	NN
cord-264884-ydkigome	702	30	,	,	,
cord-264884-ydkigome	702	31	mostly	mostly	RB
cord-264884-ydkigome	702	32	by	by	IN
cord-264884-ydkigome	702	33	prophage	prophage	NN
cord-264884-ydkigome	702	34	,	,	,
cord-264884-ydkigome	702	35	but	but	CC
cord-264884-ydkigome	702	36	they	-PRON-	PRP
cord-264884-ydkigome	702	37	also	also	RB
cord-264884-ydkigome	702	38	show	show	VBP
cord-264884-ydkigome	702	39	the	the	DT
cord-264884-ydkigome	702	40	presence	presence	NN
cord-264884-ydkigome	702	41	tRNA	trna	NN
cord-264884-ydkigome	702	42	-	-	HYPH
cord-264884-ydkigome	702	43	adjacent	adjacent	JJ
cord-264884-ydkigome	702	44	defective	defective	JJ
cord-264884-ydkigome	702	45	prophage	prophage	NN
cord-264884-ydkigome	702	46	and	and	CC
cord-264884-ydkigome	702	47	plasmid	plasmid	NN
cord-264884-ydkigome	702	48	elements	element	NNS
cord-264884-ydkigome	702	49	that	that	WDT
cord-264884-ydkigome	702	50	differentiate	differentiate	VBP
cord-264884-ydkigome	702	51	these	these	DT
cord-264884-ydkigome	702	52	strains	strain	NNS
cord-264884-ydkigome	702	53	(	(	-LRB-
cord-264884-ydkigome	702	54	Hurtado	Hurtado	NNP
cord-264884-ydkigome	702	55	and	and	CC
cord-264884-ydkigome	702	56	Rodriguez	Rodriguez	NNP
cord-264884-ydkigome	702	57	-	-	HYPH
cord-264884-ydkigome	702	58	Valera	Valera	NNP
cord-264884-ydkigome	702	59	,	,	,
cord-264884-ydkigome	702	60	1999	1999	CD
cord-264884-ydkigome	702	61	;	;	:
cord-264884-ydkigome	703	1	Mazel	Mazel	NNP
cord-264884-ydkigome	703	2	et	et	NNP
cord-264884-ydkigome	703	3	al	al	NNP
cord-264884-ydkigome	703	4	.	.	.
cord-264884-ydkigome	704	1	,	,	,
cord-264884-ydkigome	704	2	2000	2000	CD
cord-264884-ydkigome	704	3	;	;	:
cord-264884-ydkigome	704	4	Nilsson	Nilsson	NNP
cord-264884-ydkigome	704	5	et	et	NNP
cord-264884-ydkigome	704	6	al	al	NNP
cord-264884-ydkigome	704	7	.	.	NNP
cord-264884-ydkigome	704	8	,	,	,
cord-264884-ydkigome	704	9	2004	2004	CD
cord-264884-ydkigome	704	10	)	)	-RRB-
cord-264884-ydkigome	704	11	.	.	.
cord-264884-ydkigome	705	1	Cyanobacteria	Cyanobacteria	NNP
cord-264884-ydkigome	705	2	(	(	-LRB-
cord-264884-ydkigome	705	3	Prochlorococcus	Prochlorococcus	NNP
cord-264884-ydkigome	705	4	)	)	-RRB-
cord-264884-ydkigome	705	5	is	be	VBZ
cord-264884-ydkigome	705	6	major	major	JJ
cord-264884-ydkigome	705	7	model	model	NN
cord-264884-ydkigome	705	8	for	for	IN
cord-264884-ydkigome	705	9	the	the	DT
cord-264884-ydkigome	705	10	study	study	NN
cord-264884-ydkigome	705	11	of	of	IN
cord-264884-ydkigome	705	12	the	the	DT
cord-264884-ydkigome	705	13	origin	origin	NN
cord-264884-ydkigome	705	14	of	of	IN
cord-264884-ydkigome	705	15	the	the	DT
cord-264884-ydkigome	705	16	type	type	NN
cord-264884-ydkigome	705	17	II	II	NNP
cord-264884-ydkigome	705	18	(	(	-LRB-
cord-264884-ydkigome	705	19	plant	plant	NN
cord-264884-ydkigome	705	20	-	-	HYPH
cord-264884-ydkigome	705	21	like	like	JJ
cord-264884-ydkigome	705	22	)	)	-RRB-
cord-264884-ydkigome	705	23	photosynthetic	photosynthetic	JJ
cord-264884-ydkigome	705	24	system	system	NN
cord-264884-ydkigome	705	25	.	.	.
cord-264884-ydkigome	706	1	Since	since	IN
cord-264884-ydkigome	706	2	such	such	JJ
cord-264884-ydkigome	706	3	genes	gene	NNS
cord-264884-ydkigome	706	4	show	show	VBP
cord-264884-ydkigome	706	5	much	much	JJ
cord-264884-ydkigome	706	6	evidence	evidence	NN
cord-264884-ydkigome	706	7	of	of	IN
cord-264884-ydkigome	706	8	recent	recent	JJ
cord-264884-ydkigome	706	9	and	and	CC
cord-264884-ydkigome	706	10	massive	massive	JJ
cord-264884-ydkigome	706	11	horizontal	horizontal	JJ
cord-264884-ydkigome	706	12	movement	movement	NN
cord-264884-ydkigome	706	13	,	,	,
cord-264884-ydkigome	706	14	it	-PRON-	PRP
cord-264884-ydkigome	706	15	seem	seem	VBP
cord-264884-ydkigome	706	16	quite	quite	RB
cord-264884-ydkigome	706	17	likely	likely	JJ
cord-264884-ydkigome	706	18	that	that	IN
cord-264884-ydkigome	706	19	prophage	prophage	NN
cord-264884-ydkigome	706	20	are	be	VBP
cord-264884-ydkigome	706	21	mediators	mediator	NNS
cord-264884-ydkigome	706	22	of	of	IN
cord-264884-ydkigome	706	23	such	such	JJ
cord-264884-ydkigome	706	24	transfers	transfer	NNS
cord-264884-ydkigome	706	25	,	,	,
cord-264884-ydkigome	706	26	especially	especially	RB
cord-264884-ydkigome	706	27	as	as	IN
cord-264884-ydkigome	706	28	these	these	DT
cord-264884-ydkigome	706	29	phage	phage	NN
cord-264884-ydkigome	706	30	encode	encode	VBP
cord-264884-ydkigome	706	31	their	-PRON-	PRP$
cord-264884-ydkigome	706	32	own	own	JJ
cord-264884-ydkigome	706	33	version	version	NN
cord-264884-ydkigome	706	34	of	of	IN
cord-264884-ydkigome	706	35	these	these	DT
cord-264884-ydkigome	706	36	photosynthetic	photosynthetic	JJ
cord-264884-ydkigome	706	37	genes	gene	NNS
cord-264884-ydkigome	706	38	(	(	-LRB-
cord-264884-ydkigome	706	39	Lindell	Lindell	NNP
cord-264884-ydkigome	706	40	et	et	NNP
cord-264884-ydkigome	706	41	al	al	NNP
cord-264884-ydkigome	706	42	.	.	NNP
cord-264884-ydkigome	706	43	,	,	,
cord-264884-ydkigome	706	44	2004	2004	CD
cord-264884-ydkigome	706	45	;	;	:
cord-264884-ydkigome	706	46	Sullivan	Sullivan	NNP
cord-264884-ydkigome	706	47	et	et	NNP
cord-264884-ydkigome	706	48	al	al	NNP
cord-264884-ydkigome	706	49	.	.	NNP
cord-264884-ydkigome	706	50	,	,	,
cord-264884-ydkigome	706	51	2006	2006	CD
cord-264884-ydkigome	706	52	)	)	-RRB-
cord-264884-ydkigome	706	53	.	.	.
cord-264884-ydkigome	707	1	Very	very	RB
cord-264884-ydkigome	707	2	similar	similar	JJ
cord-264884-ydkigome	707	3	Prochlorococcus	Prochlorococcus	NNP
cord-264884-ydkigome	707	4	strains	strain	NNS
cord-264884-ydkigome	707	5	exist	exist	VBP
cord-264884-ydkigome	707	6	in	in	IN
cord-264884-ydkigome	707	7	distinct	distinct	JJ
cord-264884-ydkigome	707	8	oceanic	oceanic	JJ
cord-264884-ydkigome	707	9	populations	population	NNS
cord-264884-ydkigome	707	10	in	in	IN
cord-264884-ydkigome	707	11	various	various	JJ
cord-264884-ydkigome	707	12	habitats	habitat	NNS
cord-264884-ydkigome	707	13	known	know	VBN
cord-264884-ydkigome	707	14	as	as	IN
cord-264884-ydkigome	707	15	ecotypes	ecotype	NNS
cord-264884-ydkigome	707	16	.	.	.
cord-264884-ydkigome	708	1	Some	some	DT
cord-264884-ydkigome	708	2	think	think	VBP
cord-264884-ydkigome	708	3	that	that	IN
cord-264884-ydkigome	708	4	such	such	JJ
cord-264884-ydkigome	708	5	ecotypes	ecotype	NNS
cord-264884-ydkigome	708	6	represent	represent	VBP
cord-264884-ydkigome	708	7	the	the	DT
cord-264884-ydkigome	708	8	initial	initial	JJ
cord-264884-ydkigome	708	9	type	type	NN
cord-264884-ydkigome	708	10	of	of	IN
cord-264884-ydkigome	708	11	genetic	genetic	JJ
cord-264884-ydkigome	708	12	variation	variation	NN
cord-264884-ydkigome	708	13	that	that	WDT
cord-264884-ydkigome	708	14	leads	lead	VBZ
cord-264884-ydkigome	708	15	to	to	IN
cord-264884-ydkigome	708	16	speciation	speciation	NN
cord-264884-ydkigome	708	17	.	.	.
cord-264884-ydkigome	709	1	The	the	DT
cord-264884-ydkigome	709	2	sequencing	sequencing	NN
cord-264884-ydkigome	709	3	of	of	IN
cord-264884-ydkigome	709	4	six	six	CD
cord-264884-ydkigome	709	5	ecotypes	ecotype	NNS
cord-264884-ydkigome	709	6	has	have	VBZ
cord-264884-ydkigome	709	7	shown	show	VBN
cord-264884-ydkigome	709	8	that	that	IN
cord-264884-ydkigome	709	9	they	-PRON-	PRP
cord-264884-ydkigome	709	10	are	be	VBP
cord-264884-ydkigome	709	11	99	99	CD
cord-264884-ydkigome	709	12	%	%	NN
cord-264884-ydkigome	709	13	similar	similar	JJ
cord-264884-ydkigome	709	14	to	to	IN
cord-264884-ydkigome	709	15	one	one	CD
cord-264884-ydkigome	709	16	another	another	DT
cord-264884-ydkigome	709	17	,	,	,
cord-264884-ydkigome	709	18	but	but	CC
cord-264884-ydkigome	709	19	the	the	DT
cord-264884-ydkigome	709	20	genetic	genetic	JJ
cord-264884-ydkigome	709	21	variation	variation	NN
cord-264884-ydkigome	709	22	that	that	WDT
cord-264884-ydkigome	709	23	distinguishes	distinguish	VBZ
cord-264884-ydkigome	709	24	them	-PRON-	PRP
cord-264884-ydkigome	709	25	is	be	VBZ
cord-264884-ydkigome	709	26	mostly	mostly	RB
cord-264884-ydkigome	709	27	due	due	JJ
cord-264884-ydkigome	709	28	to	to	IN
cord-264884-ydkigome	709	29	patterns	pattern	NNS
cord-264884-ydkigome	709	30	of	of	IN
cord-264884-ydkigome	709	31	prophage	prophage	NN
cord-264884-ydkigome	709	32	colonization	colonization	NN
cord-264884-ydkigome	709	33	(	(	-LRB-
cord-264884-ydkigome	709	34	called	call	VBN
cord-264884-ydkigome	709	35	phage	phage	NN
cord-264884-ydkigome	709	36	islands	island	NNS
cord-264884-ydkigome	709	37	)	)	-RRB-
cord-264884-ydkigome	710	1	(	(	-LRB-
cord-264884-ydkigome	710	2	Bouman	Bouman	NNP
cord-264884-ydkigome	710	3	et	et	NNP
cord-264884-ydkigome	710	4	al	al	NNP
cord-264884-ydkigome	710	5	.	.	NNP
cord-264884-ydkigome	710	6	,	,	,
cord-264884-ydkigome	710	7	2006	2006	CD
cord-264884-ydkigome	711	1	;	;	:
cord-264884-ydkigome	711	2	Coleman	Coleman	NNP
cord-264884-ydkigome	711	3	et	et	NNP
cord-264884-ydkigome	711	4	al	al	NNP
cord-264884-ydkigome	711	5	.	.	NNP
cord-264884-ydkigome	711	6	,	,	,
cord-264884-ydkigome	711	7	2006	2006	CD
cord-264884-ydkigome	711	8	)	)	-RRB-
cord-264884-ydkigome	711	9	.	.	.
cord-264884-ydkigome	712	1	Thus	thus	RB
cord-264884-ydkigome	712	2	in	in	IN
cord-264884-ydkigome	712	3	all	all	PDT
cord-264884-ydkigome	712	4	these	these	DT
cord-264884-ydkigome	712	5	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	712	6	models	model	NNS
cord-264884-ydkigome	712	7	,	,	,
cord-264884-ydkigome	712	8	persisting	persist	VBG
cord-264884-ydkigome	712	9	viruses	virus	NNS
cord-264884-ydkigome	712	10	play	play	VBP
cord-264884-ydkigome	712	11	a	a	DT
cord-264884-ydkigome	712	12	fundamental	fundamental	JJ
cord-264884-ydkigome	712	13	role	role	NN
cord-264884-ydkigome	712	14	in	in	IN
cord-264884-ydkigome	712	15	host	host	NN
cord-264884-ydkigome	712	16	evolution	evolution	NN
cord-264884-ydkigome	712	17	and	and	CC
cord-264884-ydkigome	712	18	host	host	NN
cord-264884-ydkigome	712	19	genetic	genetic	JJ
cord-264884-ydkigome	712	20	novelty	novelty	NN
cord-264884-ydkigome	712	21	is	be	VBZ
cord-264884-ydkigome	712	22	mostly	mostly	RB
cord-264884-ydkigome	712	23	phage	phage	NN
cord-264884-ydkigome	712	24	derived	derive	VBN
cord-264884-ydkigome	712	25	.	.	.
cord-264884-ydkigome	713	1	Such	such	JJ
cord-264884-ydkigome	713	2	observations	observation	NNS
cord-264884-ydkigome	713	3	have	have	VBP
cord-264884-ydkigome	713	4	led	lead	VBN
cord-264884-ydkigome	713	5	some	some	DT
cord-264884-ydkigome	713	6	to	to	TO
cord-264884-ydkigome	713	7	propose	propose	VB
cord-264884-ydkigome	713	8	that	that	IN
cord-264884-ydkigome	713	9	"	"	``
cord-264884-ydkigome	713	10	war	war	NN
cord-264884-ydkigome	713	11	is	be	VBZ
cord-264884-ydkigome	713	12	peace	peace	NN
cord-264884-ydkigome	713	13	"	"	''
cord-264884-ydkigome	713	14	regarding	regard	VBG
cord-264884-ydkigome	713	15	virus	virus	NN
cord-264884-ydkigome	713	16	-	-	HYPH
cord-264884-ydkigome	713	17	host	host	NN
cord-264884-ydkigome	713	18	evolution	evolution	NN
cord-264884-ydkigome	713	19	(	(	-LRB-
cord-264884-ydkigome	713	20	Comeau	Comeau	NNP
cord-264884-ydkigome	713	21	and	and	CC
cord-264884-ydkigome	713	22	Krisch	Krisch	NNP
cord-264884-ydkigome	713	23	,	,	,
cord-264884-ydkigome	713	24	2005	2005	CD
cord-264884-ydkigome	713	25	)	)	-RRB-
cord-264884-ydkigome	713	26	.	.	.
cord-264884-ydkigome	714	1	Massive	massive	JJ
cord-264884-ydkigome	714	2	and	and	CC
cord-264884-ydkigome	714	3	complex	complex	JJ
cord-264884-ydkigome	714	4	innovation	innovation	NN
cord-264884-ydkigome	714	5	by	by	IN
cord-264884-ydkigome	714	6	phage	phage	NN
cord-264884-ydkigome	714	7	appears	appear	VBZ
cord-264884-ydkigome	714	8	to	to	TO
cord-264884-ydkigome	714	9	be	be	VB
cord-264884-ydkigome	714	10	a	a	DT
cord-264884-ydkigome	714	11	major	major	JJ
cord-264884-ydkigome	714	12	force	force	NN
cord-264884-ydkigome	714	13	in	in	IN
cord-264884-ydkigome	714	14	the	the	DT
cord-264884-ydkigome	714	15	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	714	16	world	world	NN
cord-264884-ydkigome	714	17	.	.	.
cord-264884-ydkigome	715	1	Prokaryotes	prokaryote	NNS
cord-264884-ydkigome	715	2	are	be	VBP
cord-264884-ydkigome	715	3	the	the	DT
cord-264884-ydkigome	715	4	most	most	RBS
cord-264884-ydkigome	715	5	adaptable	adaptable	JJ
cord-264884-ydkigome	715	6	of	of	IN
cord-264884-ydkigome	715	7	all	all	DT
cord-264884-ydkigome	715	8	cells	cell	NNS
cord-264884-ydkigome	715	9	.	.	.
cord-264884-ydkigome	716	1	If	if	IN
cord-264884-ydkigome	716	2	we	-PRON-	PRP
cord-264884-ydkigome	716	3	can	can	MD
cord-264884-ydkigome	716	4	accept	accept	VB
cord-264884-ydkigome	716	5	the	the	DT
cord-264884-ydkigome	716	6	above	above	JJ
cord-264884-ydkigome	716	7	conclusion	conclusion	NN
cord-264884-ydkigome	716	8	concerning	concern	VBG
cord-264884-ydkigome	716	9	the	the	DT
cord-264884-ydkigome	716	10	role	role	NN
cord-264884-ydkigome	716	11	for	for	IN
cord-264884-ydkigome	716	12	viruses	virus	NNS
cord-264884-ydkigome	716	13	in	in	IN
cord-264884-ydkigome	716	14	the	the	DT
cord-264884-ydkigome	716	15	evolution	evolution	NN
cord-264884-ydkigome	716	16	of	of	IN
cord-264884-ydkigome	716	17	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	716	18	,	,	,
cord-264884-ydkigome	716	19	we	-PRON-	PRP
cord-264884-ydkigome	716	20	must	must	MD
cord-264884-ydkigome	716	21	then	then	RB
cord-264884-ydkigome	716	22	ask	ask	VB
cord-264884-ydkigome	716	23	why	why	WRB
cord-264884-ydkigome	716	24	such	such	PDT
cord-264884-ydkigome	716	25	a	a	DT
cord-264884-ydkigome	716	26	successful	successful	JJ
cord-264884-ydkigome	716	27	evolutionary	evolutionary	JJ
cord-264884-ydkigome	716	28	strategy	strategy	NN
cord-264884-ydkigome	716	29	was	be	VBD
cord-264884-ydkigome	716	30	not	not	RB
cord-264884-ydkigome	716	31	apparently	apparently	RB
cord-264884-ydkigome	716	32	maintained	maintain	VBN
cord-264884-ydkigome	716	33	in	in	IN
cord-264884-ydkigome	716	34	eukaryotes	eukaryote	NNS
cord-264884-ydkigome	716	35	?	?	.
cord-264884-ydkigome	717	1	In	in	IN
cord-264884-ydkigome	717	2	eukaryotes	eukaryote	NNS
cord-264884-ydkigome	717	3	we	-PRON-	PRP
cord-264884-ydkigome	717	4	see	see	VBP
cord-264884-ydkigome	717	5	little	little	JJ
cord-264884-ydkigome	717	6	evidence	evidence	NN
cord-264884-ydkigome	717	7	that	that	IN
cord-264884-ydkigome	717	8	largescale	largescale	JJ
cord-264884-ydkigome	717	9	integration	integration	NN
cord-264884-ydkigome	717	10	by	by	IN
cord-264884-ydkigome	717	11	DNA	dna	NN
cord-264884-ydkigome	717	12	viruses	virus	NNS
cord-264884-ydkigome	717	13	is	be	VBZ
cord-264884-ydkigome	717	14	an	an	DT
cord-264884-ydkigome	717	15	important	important	JJ
cord-264884-ydkigome	717	16	evolutionary	evolutionary	JJ
cord-264884-ydkigome	717	17	process	process	NN
cord-264884-ydkigome	717	18	(	(	-LRB-
cord-264884-ydkigome	717	19	although	although	IN
cord-264884-ydkigome	717	20	the	the	DT
cord-264884-ydkigome	717	21	story	story	NN
cord-264884-ydkigome	717	22	with	with	IN
cord-264884-ydkigome	717	23	retroviruses	retrovirus	NNS
cord-264884-ydkigome	717	24	is	be	VBZ
cord-264884-ydkigome	717	25	different	different	JJ
cord-264884-ydkigome	717	26	)	)	-RRB-
cord-264884-ydkigome	717	27	.	.	.
cord-264884-ydkigome	718	1	Why	why	WRB
cord-264884-ydkigome	718	2	should	should	MD
cord-264884-ydkigome	718	3	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	718	4	and	and	CC
cord-264884-ydkigome	718	5	eukaryotes	eukaryote	NNS
cord-264884-ydkigome	718	6	differ	differ	VBP
cord-264884-ydkigome	718	7	is	be	VBZ
cord-264884-ydkigome	718	8	such	such	PDT
cord-264884-ydkigome	718	9	a	a	DT
cord-264884-ydkigome	718	10	fundamental	fundamental	JJ
cord-264884-ydkigome	718	11	way	way	NN
cord-264884-ydkigome	718	12	?	?	.
cord-264884-ydkigome	719	1	Nevertheless	nevertheless	RB
cord-264884-ydkigome	719	2	,	,	,
cord-264884-ydkigome	719	3	as	as	IN
cord-264884-ydkigome	719	4	noted	note	VBN
cord-264884-ydkigome	719	5	at	at	IN
cord-264884-ydkigome	719	6	the	the	DT
cord-264884-ydkigome	719	7	start	start	NN
cord-264884-ydkigome	719	8	of	of	IN
cord-264884-ydkigome	719	9	this	this	DT
cord-264884-ydkigome	719	10	section	section	NN
cord-264884-ydkigome	719	11	,	,	,
cord-264884-ydkigome	719	12	we	-PRON-	PRP
cord-264884-ydkigome	719	13	do	do	VBP
cord-264884-ydkigome	719	14	see	see	VB
cord-264884-ydkigome	719	15	good	good	JJ
cord-264884-ydkigome	719	16	evidence	evidence	NN
cord-264884-ydkigome	719	17	that	that	WDT
cord-264884-ydkigome	719	18	links	link	VBZ
cord-264884-ydkigome	719	19	the	the	DT
cord-264884-ydkigome	719	20	evolution	evolution	NN
cord-264884-ydkigome	719	21	of	of	IN
cord-264884-ydkigome	719	22	large	large	JJ
cord-264884-ydkigome	719	23	DNA	dna	NN
cord-264884-ydkigome	719	24	viruses	virus	NNS
cord-264884-ydkigome	719	25	of	of	IN
cord-264884-ydkigome	719	26	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	719	27	to	to	IN
cord-264884-ydkigome	719	28	the	the	DT
cord-264884-ydkigome	719	29	large	large	JJ
cord-264884-ydkigome	719	30	DNA	dna	NN
cord-264884-ydkigome	719	31	viruses	virus	NNS
cord-264884-ydkigome	719	32	of	of	IN
cord-264884-ydkigome	719	33	eukaryotes	eukaryote	NNS
cord-264884-ydkigome	719	34	.	.	.
cord-264884-ydkigome	720	1	In	in	IN
cord-264884-ydkigome	720	2	case	case	NN
cord-264884-ydkigome	720	3	we	-PRON-	PRP
cord-264884-ydkigome	720	4	were	be	VBD
cord-264884-ydkigome	720	5	becoming	become	VBG
cord-264884-ydkigome	720	6	comfortable	comfortable	JJ
cord-264884-ydkigome	720	7	with	with	IN
cord-264884-ydkigome	720	8	the	the	DT
cord-264884-ydkigome	720	9	apparently	apparently	RB
cord-264884-ydkigome	720	10	clear	clear	JJ
cord-264884-ydkigome	720	11	distinctions	distinction	NNS
cord-264884-ydkigome	720	12	between	between	IN
cord-264884-ydkigome	720	13	RNA	RNA	NNP
cord-264884-ydkigome	720	14	and	and	CC
cord-264884-ydkigome	720	15	DNA	dna	NN
cord-264884-ydkigome	720	16	virus	virus	NN
cord-264884-ydkigome	720	17	evolution	evolution	NN
cord-264884-ydkigome	720	18	as	as	IN
cord-264884-ydkigome	720	19	outlined	outline	VBN
cord-264884-ydkigome	720	20	above	above	IN
cord-264884-ydkigome	720	21	(	(	-LRB-
cord-264884-ydkigome	720	22	quasispecies	quasispecie	NNS
cord-264884-ydkigome	720	23	vs.	vs.	IN
cord-264884-ydkigome	720	24	domain	domain	NN
cord-264884-ydkigome	720	25	recombination	recombination	NN
cord-264884-ydkigome	720	26	respectively	respectively	RB
cord-264884-ydkigome	720	27	)	)	-RRB-
cord-264884-ydkigome	720	28	,	,	,
cord-264884-ydkigome	720	29	the	the	DT
cord-264884-ydkigome	720	30	evolution	evolution	NN
cord-264884-ydkigome	720	31	of	of	IN
cord-264884-ydkigome	720	32	the	the	DT
cord-264884-ydkigome	720	33	parvoviruses	parvovirus	NNS
cord-264884-ydkigome	720	34	informs	inform	VBZ
cord-264884-ydkigome	720	35	us	-PRON-	PRP
cord-264884-ydkigome	720	36	that	that	IN
cord-264884-ydkigome	720	37	DNA	dna	NN
cord-264884-ydkigome	720	38	viruses	virus	NNS
cord-264884-ydkigome	720	39	can	can	MD
cord-264884-ydkigome	720	40	also	also	RB
cord-264884-ydkigome	720	41	evolve	evolve	VB
cord-264884-ydkigome	720	42	by	by	IN
cord-264884-ydkigome	720	43	a	a	DT
cord-264884-ydkigome	720	44	quasispecies	quasispecie	NNS
cord-264884-ydkigome	720	45	process	process	NN
cord-264884-ydkigome	720	46	.	.	.
cord-264884-ydkigome	721	1	Parvovirus	parvovirus	NN
cord-264884-ydkigome	721	2	evolution	evolution	NN
cord-264884-ydkigome	721	3	(	(	-LRB-
cord-264884-ydkigome	721	4	see	see	VB
cord-264884-ydkigome	721	5	Chapter	chapter	NN
cord-264884-ydkigome	721	6	17	17	CD
cord-264884-ydkigome	721	7	)	)	-RRB-
cord-264884-ydkigome	721	8	can	can	MD
cord-264884-ydkigome	721	9	show	show	VB
cord-264884-ydkigome	721	10	a	a	DT
cord-264884-ydkigome	721	11	sharp	sharp	JJ
cord-264884-ydkigome	721	12	contrast	contrast	NN
cord-264884-ydkigome	721	13	to	to	IN
cord-264884-ydkigome	721	14	the	the	DT
cord-264884-ydkigome	721	15	evolutionary	evolutionary	JJ
cord-264884-ydkigome	721	16	pattern	pattern	NN
cord-264884-ydkigome	721	17	displayed	display	VBN
cord-264884-ydkigome	721	18	by	by	IN
cord-264884-ydkigome	721	19	other	other	JJ
cord-264884-ydkigome	721	20	small	small	JJ
cord-264884-ydkigome	721	21	dsDNA	dsdna	NN
cord-264884-ydkigome	721	22	viruses	virus	NNS
cord-264884-ydkigome	721	23	above	above	RB
cord-264884-ydkigome	721	24	(	(	-LRB-
cord-264884-ydkigome	721	25	HPV	HPV	NNP
cord-264884-ydkigome	721	26	,	,	,
cord-264884-ydkigome	721	27	Py	py	NN
cord-264884-ydkigome	721	28	)	)	-RRB-
cord-264884-ydkigome	721	29	.	.	.
cord-264884-ydkigome	722	1	With	with	IN
cord-264884-ydkigome	722	2	the	the	DT
cord-264884-ydkigome	722	3	emergence	emergence	NN
cord-264884-ydkigome	722	4	of	of	IN
cord-264884-ydkigome	722	5	an	an	DT
cord-264884-ydkigome	722	6	acute	acute	JJ
cord-264884-ydkigome	722	7	pandemic	pandemic	NN
cord-264884-ydkigome	722	8	in	in	IN
cord-264884-ydkigome	722	9	domestic	domestic	JJ
cord-264884-ydkigome	722	10	dogs	dog	NNS
cord-264884-ydkigome	722	11	and	and	CC
cord-264884-ydkigome	722	12	cats	cat	NNS
cord-264884-ydkigome	722	13	(	(	-LRB-
cord-264884-ydkigome	722	14	as	as	RB
cord-264884-ydkigome	722	15	well	well	RB
cord-264884-ydkigome	722	16	as	as	IN
cord-264884-ydkigome	722	17	other	other	JJ
cord-264884-ydkigome	722	18	wild	wild	JJ
cord-264884-ydkigome	722	19	carnivore	carnivore	NN
cord-264884-ydkigome	722	20	species	specie	NNS
cord-264884-ydkigome	722	21	)	)	-RRB-
cord-264884-ydkigome	722	22	,	,	,
cord-264884-ydkigome	722	23	we	-PRON-	PRP
cord-264884-ydkigome	722	24	see	see	VBP
cord-264884-ydkigome	722	25	what	what	WP
cord-264884-ydkigome	722	26	is	be	VBZ
cord-264884-ydkigome	722	27	essentially	essentially	RB
cord-264884-ydkigome	722	28	evolution	evolution	NN
cord-264884-ydkigome	722	29	driven	drive	VBN
cord-264884-ydkigome	722	30	by	by	IN
cord-264884-ydkigome	722	31	single	single	JJ
cord-264884-ydkigome	722	32	point	point	NN
cord-264884-ydkigome	722	33	mutations	mutation	NNS
cord-264884-ydkigome	722	34	,	,	,
cord-264884-ydkigome	722	35	mostly	mostly	RB
cord-264884-ydkigome	722	36	affecting	affect	VBG
cord-264884-ydkigome	722	37	the	the	DT
cord-264884-ydkigome	722	38	capsid	capsid	JJ
cord-264884-ydkigome	722	39	genes	gene	NNS
cord-264884-ydkigome	722	40	and	and	CC
cord-264884-ydkigome	722	41	host	host	NN
cord-264884-ydkigome	722	42	cell	cell	NN
cord-264884-ydkigome	722	43	receptor	receptor	NN
cord-264884-ydkigome	722	44	binding	binding	NN
cord-264884-ydkigome	722	45	.	.	.
cord-264884-ydkigome	723	1	This	this	DT
cord-264884-ydkigome	723	2	system	system	NN
cord-264884-ydkigome	723	3	provides	provide	VBZ
cord-264884-ydkigome	723	4	us	-PRON-	PRP
cord-264884-ydkigome	723	5	with	with	IN
cord-264884-ydkigome	723	6	one	one	CD
cord-264884-ydkigome	723	7	of	of	IN
cord-264884-ydkigome	723	8	the	the	DT
cord-264884-ydkigome	723	9	better	well	RBR
cord-264884-ydkigome	723	10	studied	study	VBN
cord-264884-ydkigome	723	11	examples	example	NNS
cord-264884-ydkigome	723	12	of	of	IN
cord-264884-ydkigome	723	13	the	the	DT
cord-264884-ydkigome	723	14	evolutionary	evolutionary	JJ
cord-264884-ydkigome	723	15	dynamics	dynamic	NNS
cord-264884-ydkigome	723	16	of	of	IN
cord-264884-ydkigome	723	17	an	an	DT
cord-264884-ydkigome	723	18	emergent	emergent	JJ
cord-264884-ydkigome	723	19	viral	viral	JJ
cord-264884-ydkigome	723	20	disease	disease	NN
cord-264884-ydkigome	723	21	.	.	.
cord-264884-ydkigome	724	1	In	in	IN
cord-264884-ydkigome	724	2	addition	addition	NN
cord-264884-ydkigome	724	3	,	,	,
cord-264884-ydkigome	724	4	in	in	IN
cord-264884-ydkigome	724	5	vivo	vivo	NNP
cord-264884-ydkigome	724	6	mouse	mouse	NN
cord-264884-ydkigome	724	7	studies	study	NNS
cord-264884-ydkigome	724	8	with	with	IN
cord-264884-ydkigome	724	9	minute	minute	JJ
cord-264884-ydkigome	724	10	virus	virus	NN
cord-264884-ydkigome	724	11	of	of	IN
cord-264884-ydkigome	724	12	mouse	mouse	NN
cord-264884-ydkigome	724	13	(	(	-LRB-
cord-264884-ydkigome	724	14	MVM	MVM	NNP
cord-264884-ydkigome	724	15	)	)	-RRB-
cord-264884-ydkigome	724	16	now	now	RB
cord-264884-ydkigome	724	17	make	make	VBP
cord-264884-ydkigome	724	18	it	-PRON-	PRP
cord-264884-ydkigome	724	19	clear	clear	JJ
cord-264884-ydkigome	724	20	that	that	IN
cord-264884-ydkigome	724	21	parvoviruses	parvovirus	NNS
cord-264884-ydkigome	724	22	can	can	MD
cord-264884-ydkigome	724	23	behave	behave	VB
cord-264884-ydkigome	724	24	much	much	RB
cord-264884-ydkigome	724	25	like	like	IN
cord-264884-ydkigome	724	26	RNA	RNA	NNP
cord-264884-ydkigome	724	27	viruses	virus	NNS
cord-264884-ydkigome	724	28	,	,	,
cord-264884-ydkigome	724	29	generating	generate	VBG
cord-264884-ydkigome	724	30	quasispecies	quasispecie	NNS
cord-264884-ydkigome	724	31	of	of	IN
cord-264884-ydkigome	724	32	diverse	diverse	JJ
cord-264884-ydkigome	724	33	progeny	progeny	NN
cord-264884-ydkigome	724	34	that	that	WDT
cord-264884-ydkigome	724	35	allow	allow	VBP
cord-264884-ydkigome	724	36	a	a	DT
cord-264884-ydkigome	724	37	high	high	JJ
cord-264884-ydkigome	724	38	adaptability	adaptability	NN
cord-264884-ydkigome	724	39	for	for	IN
cord-264884-ydkigome	724	40	the	the	DT
cord-264884-ydkigome	724	41	generation	generation	NN
cord-264884-ydkigome	724	42	of	of	IN
cord-264884-ydkigome	724	43	fi	fi	NN
cord-264884-ydkigome	724	44	tness	tness	NN
cord-264884-ydkigome	724	45	and	and	CC
cord-264884-ydkigome	724	46	disease	disease	NN
cord-264884-ydkigome	724	47	in	in	IN
cord-264884-ydkigome	724	48	vivo	vivo	NNP
cord-264884-ydkigome	725	1	(	(	-LRB-
cord-264884-ydkigome	725	2	Lopez	Lopez	NNP
cord-264884-ydkigome	725	3	-	-	HYPH
cord-264884-ydkigome	725	4	Bueno	Bueno	NNP
cord-264884-ydkigome	725	5	et	et	FW
cord-264884-ydkigome	725	6	al	al	NNP
cord-264884-ydkigome	725	7	.	.	NNP
cord-264884-ydkigome	725	8	,	,	,
cord-264884-ydkigome	725	9	2006	2006	CD
cord-264884-ydkigome	725	10	)	)	-RRB-
cord-264884-ydkigome	725	11	.	.	.
cord-264884-ydkigome	726	1	This	this	DT
cord-264884-ydkigome	726	2	story	story	NN
cord-264884-ydkigome	726	3	is	be	VBZ
cord-264884-ydkigome	726	4	very	very	RB
cord-264884-ydkigome	726	5	reminiscent	reminiscent	JJ
cord-264884-ydkigome	726	6	of	of	IN
cord-264884-ydkigome	726	7	the	the	DT
cord-264884-ydkigome	726	8	study	study	NN
cord-264884-ydkigome	726	9	of	of	IN
cord-264884-ydkigome	726	10	poliovirus	poliovirus	NN
cord-264884-ydkigome	726	11	in	in	IN
cord-264884-ydkigome	726	12	mice	mouse	NNS
cord-264884-ydkigome	726	13	mentioned	mention	VBN
cord-264884-ydkigome	726	14	above	above	RB
cord-264884-ydkigome	726	15	.	.	.
cord-264884-ydkigome	727	1	Human	human	JJ
cord-264884-ydkigome	727	2	studies	study	NNS
cord-264884-ydkigome	727	3	with	with	IN
cord-264884-ydkigome	727	4	B19	B19	NNP
cord-264884-ydkigome	727	5	parvovirus	parvovirus	NN
cord-264884-ydkigome	727	6	are	be	VBP
cord-264884-ydkigome	727	7	also	also	RB
cord-264884-ydkigome	727	8	consistent	consistent	JJ
cord-264884-ydkigome	727	9	with	with	IN
cord-264884-ydkigome	727	10	high	high	JJ
cord-264884-ydkigome	727	11	mutation	mutation	NN
cord-264884-ydkigome	727	12	rates	rate	NNS
cord-264884-ydkigome	727	13	(	(	-LRB-
cord-264884-ydkigome	727	14	Parsyan	Parsyan	NNP
cord-264884-ydkigome	727	15	et	et	NNP
cord-264884-ydkigome	727	16	al	al	NNP
cord-264884-ydkigome	727	17	.	.	NNP
cord-264884-ydkigome	727	18	,	,	,
cord-264884-ydkigome	727	19	2007	2007	CD
cord-264884-ydkigome	727	20	;	;	:
cord-264884-ydkigome	727	21	Shackelton	Shackelton	NNP
cord-264884-ydkigome	727	22	and	and	CC
cord-264884-ydkigome	727	23	Holmes	Holmes	NNP
cord-264884-ydkigome	727	24	,	,	,
cord-264884-ydkigome	727	25	2006	2006	CD
cord-264884-ydkigome	727	26	)	)	-RRB-
cord-264884-ydkigome	727	27	.	.	.
cord-264884-ydkigome	728	1	Although	although	IN
cord-264884-ydkigome	728	2	not	not	RB
cord-264884-ydkigome	728	3	specifi	specifi	VBN
cord-264884-ydkigome	728	4	cally	cally	RB
cord-264884-ydkigome	728	5	addressed	address	VBN
cord-264884-ydkigome	728	6	in	in	IN
cord-264884-ydkigome	728	7	this	this	DT
cord-264884-ydkigome	728	8	volume	volume	NN
cord-264884-ydkigome	728	9	,	,	,
cord-264884-ydkigome	728	10	the	the	DT
cord-264884-ydkigome	728	11	viruses	virus	NNS
cord-264884-ydkigome	728	12	of	of	IN
cord-264884-ydkigome	728	13	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	728	14	unicellular	unicellular	JJ
cord-264884-ydkigome	728	15	green	green	JJ
cord-264884-ydkigome	728	16	algae	algae	NN
cord-264884-ydkigome	728	17	are	be	VBP
cord-264884-ydkigome	728	18	of	of	IN
cord-264884-ydkigome	728	19	special	special	JJ
cord-264884-ydkigome	728	20	interest	interest	NN
cord-264884-ydkigome	728	21	from	from	IN
cord-264884-ydkigome	728	22	the	the	DT
cord-264884-ydkigome	728	23	perspective	perspective	NN
cord-264884-ydkigome	728	24	of	of	IN
cord-264884-ydkigome	728	25	DNA	dna	NN
cord-264884-ydkigome	728	26	virus	virus	NN
cord-264884-ydkigome	728	27	evolution	evolution	NN
cord-264884-ydkigome	728	28	.	.	.
cord-264884-ydkigome	729	1	These	these	DT
cord-264884-ydkigome	729	2	large	large	JJ
cord-264884-ydkigome	729	3	,	,	,
cord-264884-ydkigome	729	4	complex	complex	JJ
cord-264884-ydkigome	729	5	dsDNA	dsdna	RB
cord-264884-ydkigome	729	6	membrane	membrane	NN
cord-264884-ydkigome	729	7	-	-	HYPH
cord-264884-ydkigome	729	8	containing	contain	VBG
cord-264884-ydkigome	729	9	icosahedral	icosahedral	JJ
cord-264884-ydkigome	729	10	viruses	virus	NNS
cord-264884-ydkigome	729	11	are	be	VBP
cord-264884-ydkigome	729	12	abundant	abundant	JJ
cord-264884-ydkigome	729	13	in	in	IN
cord-264884-ydkigome	729	14	some	some	DT
cord-264884-ydkigome	729	15	water	water	NN
cord-264884-ydkigome	729	16	habitats	habitat	NNS
cord-264884-ydkigome	729	17	(	(	-LRB-
cord-264884-ydkigome	729	18	Van	Van	NNP
cord-264884-ydkigome	729	19	Etten	Etten	NNP
cord-264884-ydkigome	729	20	,	,	,
cord-264884-ydkigome	729	21	2003	2003	CD
cord-264884-ydkigome	729	22	;	;	:
cord-264884-ydkigome	729	23	Ghedin	Ghedin	NNP
cord-264884-ydkigome	729	24	and	and	CC
cord-264884-ydkigome	729	25	Claverie	Claverie	NNP
cord-264884-ydkigome	729	26	,	,	,
cord-264884-ydkigome	729	27	2005	2005	CD
cord-264884-ydkigome	729	28	)	)	-RRB-
cord-264884-ydkigome	729	29	.	.	.
cord-264884-ydkigome	730	1	The	the	DT
cord-264884-ydkigome	730	2	reason	reason	NN
cord-264884-ydkigome	730	3	they	-PRON-	PRP
cord-264884-ydkigome	730	4	deserve	deserve	VBP
cord-264884-ydkigome	730	5	special	special	JJ
cord-264884-ydkigome	730	6	attention	attention	NN
cord-264884-ydkigome	730	7	is	be	VBZ
cord-264884-ydkigome	730	8	that	that	IN
cord-264884-ydkigome	730	9	they	-PRON-	PRP
cord-264884-ydkigome	730	10	clearly	clearly	RB
cord-264884-ydkigome	730	11	have	have	VBP
cord-264884-ydkigome	730	12	many	many	JJ
cord-264884-ydkigome	730	13	features	feature	NNS
cord-264884-ydkigome	730	14	that	that	WDT
cord-264884-ydkigome	730	15	are	be	VBP
cord-264884-ydkigome	730	16	characteristic	characteristic	JJ
cord-264884-ydkigome	730	17	of	of	IN
cord-264884-ydkigome	730	18	both	both	DT
cord-264884-ydkigome	730	19	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	730	20	and	and	CC
cord-264884-ydkigome	730	21	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	730	22	viruses	virus	NNS
cord-264884-ydkigome	730	23	.	.	.
cord-264884-ydkigome	731	1	They	-PRON-	PRP
cord-264884-ydkigome	731	2	resemble	resemble	VBP
cord-264884-ydkigome	731	3	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	731	4	viruses	virus	NNS
cord-264884-ydkigome	731	5	in	in	IN
cord-264884-ydkigome	731	6	that	that	IN
cord-264884-ydkigome	731	7	their	-PRON-	PRP$
cord-264884-ydkigome	731	8	life	life	NN
cord-264884-ydkigome	731	9	cycle	cycle	NN
cord-264884-ydkigome	731	10	is	be	VBZ
cord-264884-ydkigome	731	11	clearly	clearly	RB
cord-264884-ydkigome	731	12	phagelike	phagelike	JJ
cord-264884-ydkigome	731	13	,	,	,
cord-264884-ydkigome	731	14	such	such	JJ
cord-264884-ydkigome	731	15	as	as	IN
cord-264884-ydkigome	731	16	external	external	JJ
cord-264884-ydkigome	731	17	virion	virion	NN
cord-264884-ydkigome	731	18	attachment	attachment	NN
cord-264884-ydkigome	731	19	,	,	,
cord-264884-ydkigome	731	20	injection	injection	NN
cord-264884-ydkigome	731	21	of	of	IN
cord-264884-ydkigome	731	22	DNA	dna	NN
cord-264884-ydkigome	731	23	and	and	CC
cord-264884-ydkigome	731	24	no	no	DT
cord-264884-ydkigome	731	25	pinocytosis	pinocytosis	NN
cord-264884-ydkigome	731	26	.	.	.
cord-264884-ydkigome	732	1	In	in	IN
cord-264884-ydkigome	732	2	addition	addition	NN
cord-264884-ydkigome	732	3	,	,	,
cord-264884-ydkigome	732	4	they	-PRON-	PRP
cord-264884-ydkigome	732	5	also	also	RB
cord-264884-ydkigome	732	6	encode	encode	VBP
cord-264884-ydkigome	732	7	many	many	JJ
cord-264884-ydkigome	732	8	phage	phage	NN
cord-264884-ydkigome	732	9	-	-	HYPH
cord-264884-ydkigome	732	10	like	like	JJ
cord-264884-ydkigome	732	11	genes	gene	NNS
cord-264884-ydkigome	732	12	,	,	,
cord-264884-ydkigome	732	13	such	such	JJ
cord-264884-ydkigome	732	14	as	as	IN
cord-264884-ydkigome	732	15	restriction	restriction	NN
cord-264884-ydkigome	732	16	-	-	HYPH
cord-264884-ydkigome	732	17	modifi	modifi	NN
cord-264884-ydkigome	732	18	cation	cation	NN
cord-264884-ydkigome	732	19	enzymes	enzyme	NNS
cord-264884-ydkigome	732	20	and	and	CC
cord-264884-ydkigome	732	21	homing	homing	NN
cord-264884-ydkigome	732	22	endonucleases	endonuclease	NNS
cord-264884-ydkigome	732	23	(	(	-LRB-
cord-264884-ydkigome	732	24	Filee	Filee	NNP
cord-264884-ydkigome	732	25	et	et	FW
cord-264884-ydkigome	732	26	al	al	NNP
cord-264884-ydkigome	732	27	.	.	NNP
cord-264884-ydkigome	732	28	,	,	,
cord-264884-ydkigome	732	29	2006c	2006c	CD
cord-264884-ydkigome	732	30	)	)	-RRB-
cord-264884-ydkigome	732	31	.	.	.
cord-264884-ydkigome	733	1	They	-PRON-	PRP
cord-264884-ydkigome	733	2	also	also	RB
cord-264884-ydkigome	733	3	resemble	resemble	VBP
cord-264884-ydkigome	733	4	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	733	5	viruses	virus	NNS
cord-264884-ydkigome	733	6	in	in	IN
cord-264884-ydkigome	733	7	that	that	IN
cord-264884-ydkigome	733	8	they	-PRON-	PRP
cord-264884-ydkigome	733	9	have	have	VBP
cord-264884-ydkigome	733	10	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	733	11	DNA	dna	NN
cord-264884-ydkigome	733	12	replication	replication	NN
cord-264884-ydkigome	733	13	proteins	protein	NNS
cord-264884-ydkigome	733	14	(	(	-LRB-
cord-264884-ydkigome	733	15	DNA	dna	NN
cord-264884-ydkigome	733	16	polymerase	polymerase	NN
cord-264884-ydkigome	733	17	beta	beta	NN
cord-264884-ydkigome	733	18	and	and	CC
cord-264884-ydkigome	733	19	PCNA	PCNA	NNP
cord-264884-ydkigome	733	20	;	;	:
cord-264884-ydkigome	733	21	Chen	Chen	NNP
cord-264884-ydkigome	733	22	and	and	CC
cord-264884-ydkigome	733	23	Suttle	Suttle	NNP
cord-264884-ydkigome	733	24	,	,	,
cord-264884-ydkigome	733	25	1996	1996	CD
cord-264884-ydkigome	733	26	;	;	:
cord-264884-ydkigome	734	1	Nagasaki	Nagasaki	NNP
cord-264884-ydkigome	734	2	et	et	NNP
cord-264884-ydkigome	734	3	al	al	NNP
cord-264884-ydkigome	734	4	.	.	NNP
cord-264884-ydkigome	734	5	,	,	,
cord-264884-ydkigome	734	6	2005	2005	CD
cord-264884-ydkigome	734	7	;	;	:
cord-264884-ydkigome	735	1	Villarreal	Villarreal	NNP
cord-264884-ydkigome	735	2	and	and	CC
cord-264884-ydkigome	735	3	DeFilippis	DeFilippis	NNP
cord-264884-ydkigome	735	4	,	,	,
cord-264884-ydkigome	735	5	2000	2000	CD
cord-264884-ydkigome	735	6	)	)	-RRB-
cord-264884-ydkigome	735	7	as	as	RB
cord-264884-ydkigome	735	8	well	well	RB
cord-264884-ydkigome	735	9	as	as	IN
cord-264884-ydkigome	735	10	many	many	JJ
cord-264884-ydkigome	735	11	genes	gene	NNS
cord-264884-ydkigome	735	12	associated	associate	VBN
cord-264884-ydkigome	735	13	with	with	IN
cord-264884-ydkigome	735	14	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	735	15	signal	signal	NN
cord-264884-ydkigome	735	16	transduction	transduction	NN
cord-264884-ydkigome	736	1	(	(	-LRB-
cord-264884-ydkigome	736	2	Van	Van	NNP
cord-264884-ydkigome	736	3	Etten	Etten	NNP
cord-264884-ydkigome	736	4	et	et	NNP
cord-264884-ydkigome	736	5	al	al	NNP
cord-264884-ydkigome	736	6	.	.	NNP
cord-264884-ydkigome	736	7	,	,	,
cord-264884-ydkigome	736	8	2002	2002	CD
cord-264884-ydkigome	736	9	)	)	-RRB-
cord-264884-ydkigome	736	10	.	.	.
cord-264884-ydkigome	737	1	Thus	thus	RB
cord-264884-ydkigome	737	2	they	-PRON-	PRP
cord-264884-ydkigome	737	3	represent	represent	VBP
cord-264884-ydkigome	737	4	a	a	DT
cord-264884-ydkigome	737	5	clear	clear	JJ
cord-264884-ydkigome	737	6	link	link	NN
cord-264884-ydkigome	737	7	between	between	IN
cord-264884-ydkigome	737	8	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	737	9	and	and	CC
cord-264884-ydkigome	737	10	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	737	11	DNA	dna	NN
cord-264884-ydkigome	737	12	viruses	virus	NNS
cord-264884-ydkigome	737	13	.	.	.
cord-264884-ydkigome	738	1	For	for	IN
cord-264884-ydkigome	738	2	example	example	NN
cord-264884-ydkigome	738	3	,	,	,
cord-264884-ydkigome	738	4	the	the	DT
cord-264884-ydkigome	738	5	DNA	dna	NN
cord-264884-ydkigome	738	6	polymerase	polymerase	NN
cord-264884-ydkigome	738	7	of	of	IN
cord-264884-ydkigome	738	8	paramecium	paramecium	NNP
cord-264884-ydkigome	738	9	bursaria	bursaria	NNP
cord-264884-ydkigome	738	10	chlorella	chlorella	NNP
cord-264884-ydkigome	738	11	virus	virus	NN
cord-264884-ydkigome	738	12	(	(	-LRB-
cord-264884-ydkigome	738	13	PBCV-1	PBCV-1	NNP
cord-264884-ydkigome	738	14	)	)	-RRB-
cord-264884-ydkigome	738	15	is	be	VBZ
cord-264884-ydkigome	738	16	the	the	DT
cord-264884-ydkigome	738	17	most	most	RBS
cord-264884-ydkigome	738	18	conserved	conserved	JJ
cord-264884-ydkigome	738	19	gene	gene	NN
cord-264884-ydkigome	738	20	and	and	CC
cord-264884-ydkigome	738	21	most	most	RBS
cord-264884-ydkigome	738	22	closely	closely	RB
cord-264884-ydkigome	738	23	resembles	resemble	VBZ
cord-264884-ydkigome	738	24	that	that	WDT
cord-264884-ydkigome	738	25	found	find	VBN
cord-264884-ydkigome	738	26	in	in	IN
cord-264884-ydkigome	738	27	human	human	JJ
cord-264884-ydkigome	738	28	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	738	29	and	and	CC
cord-264884-ydkigome	738	30	is	be	VBZ
cord-264884-ydkigome	738	31	distantly	distantly	RB
cord-264884-ydkigome	738	32	related	relate	VBN
cord-264884-ydkigome	738	33	to	to	IN
cord-264884-ydkigome	738	34	the	the	DT
cord-264884-ydkigome	738	35	similar	similar	JJ
cord-264884-ydkigome	738	36	family	family	NN
cord-264884-ydkigome	738	37	DNA	dna	NN
cord-264884-ydkigome	738	38	pol	pol	NN
cord-264884-ydkigome	738	39	encoded	encode	VBN
cord-264884-ydkigome	738	40	by	by	IN
cord-264884-ydkigome	738	41	T4	T4	NNP
cord-264884-ydkigome	738	42	.	.	.
cord-264884-ydkigome	739	1	This	this	DT
cord-264884-ydkigome	739	2	polymerase	polymerase	NN
cord-264884-ydkigome	739	3	is	be	VBZ
cord-264884-ydkigome	739	4	distinct	distinct	JJ
cord-264884-ydkigome	739	5	from	from	IN
cord-264884-ydkigome	739	6	that	that	DT
cord-264884-ydkigome	739	7	of	of	IN
cord-264884-ydkigome	739	8	the	the	DT
cord-264884-ydkigome	739	9	poxviruses	poxvirus	NNS
cord-264884-ydkigome	739	10	or	or	CC
cord-264884-ydkigome	739	11	PRD1	PRD1	NNP
cord-264884-ydkigome	739	12	/	/	SYM
cord-264884-ydkigome	739	13	adenoviruses	adenovirus	NNS
cord-264884-ydkigome	739	14	(	(	-LRB-
cord-264884-ydkigome	739	15	associated	associate	VBN
cord-264884-ydkigome	739	16	with	with	IN
cord-264884-ydkigome	739	17	protein	protein	NN
cord-264884-ydkigome	739	18	-	-	HYPH
cord-264884-ydkigome	739	19	primed	prime	VBN
cord-264884-ydkigome	739	20	DNA	dna	NN
cord-264884-ydkigome	739	21	replication	replication	NN
cord-264884-ydkigome	739	22	)	)	-RRB-
cord-264884-ydkigome	739	23	.	.	.
cord-264884-ydkigome	740	1	However	however	RB
cord-264884-ydkigome	740	2	,	,	,
cord-264884-ydkigome	740	3	numerous	numerous	JJ
cord-264884-ydkigome	740	4	other	other	JJ
cord-264884-ydkigome	740	5	genes	gene	NNS
cord-264884-ydkigome	740	6	of	of	IN
cord-264884-ydkigome	740	7	the	the	DT
cord-264884-ydkigome	740	8	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	740	9	are	be	VBP
cord-264884-ydkigome	740	10	similar	similar	JJ
cord-264884-ydkigome	740	11	to	to	IN
cord-264884-ydkigome	740	12	some	some	DT
cord-264884-ydkigome	740	13	genes	gene	NNS
cord-264884-ydkigome	740	14	found	find	VBN
cord-264884-ydkigome	740	15	in	in	IN
cord-264884-ydkigome	740	16	the	the	DT
cord-264884-ydkigome	740	17	mimiviruses	mimiviruse	NNS
cord-264884-ydkigome	740	18	(	(	-LRB-
cord-264884-ydkigome	740	19	giant	giant	JJ
cord-264884-ydkigome	740	20	DNA	DNA	NNP
cord-264884-ydkigome	740	21	virus	virus	NN
cord-264884-ydkigome	740	22	of	of	IN
cord-264884-ydkigome	740	23	ameba	ameba	NNP
cord-264884-ydkigome	740	24	)	)	-RRB-
cord-264884-ydkigome	740	25	,	,	,
cord-264884-ydkigome	740	26	including	include	VBG
cord-264884-ydkigome	740	27	the	the	DT
cord-264884-ydkigome	740	28	presence	presence	NN
cord-264884-ydkigome	740	29	of	of	IN
cord-264884-ydkigome	740	30	conserved	conserved	JJ
cord-264884-ydkigome	740	31	intenes	intene	NNS
cord-264884-ydkigome	740	32	in	in	IN
cord-264884-ydkigome	740	33	the	the	DT
cord-264884-ydkigome	740	34	DNA	dna	NN
cord-264884-ydkigome	740	35	pol	pol	NN
cord-264884-ydkigome	740	36	gene	gene	NN
cord-264884-ydkigome	740	37	(	(	-LRB-
cord-264884-ydkigome	740	38	Ogata	Ogata	NNP
cord-264884-ydkigome	740	39	et	et	NNP
cord-264884-ydkigome	740	40	al	al	NNP
cord-264884-ydkigome	740	41	.	.	NNP
cord-264884-ydkigome	740	42	,	,	,
cord-264884-ydkigome	740	43	2005	2005	CD
cord-264884-ydkigome	740	44	)	)	-RRB-
cord-264884-ydkigome	740	45	.	.	.
cord-264884-ydkigome	741	1	In	in	IN
cord-264884-ydkigome	741	2	view	view	NN
cord-264884-ydkigome	741	3	of	of	IN
cord-264884-ydkigome	741	4	this	this	DT
cord-264884-ydkigome	741	5	it	-PRON-	PRP
cord-264884-ydkigome	741	6	is	be	VBZ
cord-264884-ydkigome	741	7	most	most	RBS
cord-264884-ydkigome	741	8	curious	curious	JJ
cord-264884-ydkigome	741	9	that	that	IN
cord-264884-ydkigome	741	10	in	in	IN
cord-264884-ydkigome	741	11	structural	structural	JJ
cord-264884-ydkigome	741	12	similarity	similarity	NN
cord-264884-ydkigome	741	13	,	,	,
cord-264884-ydkigome	741	14	polydnavirus	polydnavirus	NNP
cord-264884-ydkigome	741	15	capsids	capsids	NNP
cord-264884-ydkigome	741	16	clearly	clearly	RB
cord-264884-ydkigome	741	17	resemble	resemble	VBP
cord-264884-ydkigome	741	18	PRD1	PRD1	NNP
cord-264884-ydkigome	741	19	capsid	capsid	NN
cord-264884-ydkigome	741	20	(	(	-LRB-
cord-264884-ydkigome	741	21	Khayat	Khayat	NNP
cord-264884-ydkigome	741	22	et	et	FW
cord-264884-ydkigome	741	23	al	al	NNP
cord-264884-ydkigome	741	24	.	.	NNP
cord-264884-ydkigome	741	25	,	,	,
cord-264884-ydkigome	741	26	2005	2005	CD
cord-264884-ydkigome	741	27	;	;	:
cord-264884-ydkigome	742	1	Nandhagopal	Nandhagopal	NNP
cord-264884-ydkigome	742	2	et	et	NNP
cord-264884-ydkigome	742	3	al	al	NNP
cord-264884-ydkigome	742	4	.	.	NNP
cord-264884-ydkigome	742	5	,	,	,
cord-264884-ydkigome	742	6	2002	2002	CD
cord-264884-ydkigome	742	7	)	)	-RRB-
cord-264884-ydkigome	742	8	.	.	.
cord-264884-ydkigome	743	1	PRD1	PRD1	NNP
cord-264884-ydkigome	743	2	contains	contain	VBZ
cord-264884-ydkigome	743	3	the	the	DT
cord-264884-ydkigome	743	4	double	double	JJ
cord-264884-ydkigome	743	5	-	-	HYPH
cord-264884-ydkigome	743	6	barrel	barrel	NN
cord-264884-ydkigome	743	7	trimer	trimer	NN
cord-264884-ydkigome	743	8	capsid	capsid	NN
cord-264884-ydkigome	743	9	structure	structure	NN
cord-264884-ydkigome	743	10	that	that	WDT
cord-264884-ydkigome	743	11	was	be	VBD
cord-264884-ydkigome	743	12	fi	fi	NNP
cord-264884-ydkigome	743	13	rst	rst	NNP
cord-264884-ydkigome	743	14	observed	observe	VBN
cord-264884-ydkigome	743	15	in	in	IN
cord-264884-ydkigome	743	16	adenovirus	adenovirus	NN
cord-264884-ydkigome	743	17	(	(	-LRB-
cord-264884-ydkigome	743	18	for	for	IN
cord-264884-ydkigome	743	19	references	reference	NNS
cord-264884-ydkigome	743	20	see	see	VBP
cord-264884-ydkigome	743	21	Saren	Saren	NNP
cord-264884-ydkigome	743	22	et	et	NNP
cord-264884-ydkigome	743	23	al	al	NNP
cord-264884-ydkigome	743	24	.	.	NNP
cord-264884-ydkigome	743	25	,	,	,
cord-264884-ydkigome	743	26	2005	2005	CD
cord-264884-ydkigome	743	27	)	)	-RRB-
cord-264884-ydkigome	743	28	.	.	.
cord-264884-ydkigome	744	1	Adenovirus	Adenovirus	NNP
cord-264884-ydkigome	744	2	also	also	RB
cord-264884-ydkigome	744	3	closely	closely	RB
cord-264884-ydkigome	744	4	resembles	resemble	VBZ
cord-264884-ydkigome	744	5	PRD1	PRD1	NNP
cord-264884-ydkigome	744	6	in	in	IN
cord-264884-ydkigome	744	7	DNA	dna	NN
cord-264884-ydkigome	744	8	replication	replication	NN
cord-264884-ydkigome	744	9	strategy	strategy	NN
cord-264884-ydkigome	744	10	(	(	-LRB-
cord-264884-ydkigome	744	11	i.e.	i.e.	FW
cord-264884-ydkigome	744	12	linear	linear	JJ
cord-264884-ydkigome	744	13	DNA	DNA	NNP
cord-264884-ydkigome	744	14	with	with	IN
cord-264884-ydkigome	744	15	covalently	covalently	RB
cord-264884-ydkigome	744	16	closed	close	VBN
cord-264884-ydkigome	744	17	ends	end	NNS
cord-264884-ydkigome	745	1	(	(	-LRB-
cord-264884-ydkigome	745	2	Benson	Benson	NNP
cord-264884-ydkigome	745	3	et	et	NNP
cord-264884-ydkigome	745	4	al	al	NNP
cord-264884-ydkigome	745	5	.	.	NNP
cord-264884-ydkigome	745	6	,	,	,
cord-264884-ydkigome	745	7	2004	2004	CD
cord-264884-ydkigome	745	8	;	;	:
cord-264884-ydkigome	745	9	Khayat	Khayat	NNP
cord-264884-ydkigome	745	10	et	et	NNP
cord-264884-ydkigome	745	11	al	al	NNP
cord-264884-ydkigome	745	12	.	.	NNP
cord-264884-ydkigome	745	13	,	,	,
cord-264884-ydkigome	745	14	2005	2005	CD
cord-264884-ydkigome	745	15	)	)	-RRB-
cord-264884-ydkigome	745	16	.	.	.
cord-264884-ydkigome	746	1	The	the	DT
cord-264884-ydkigome	746	2	lineage	lineage	NN
cord-264884-ydkigome	746	3	of	of	IN
cord-264884-ydkigome	746	4	adenovirus	adenovirus	NN
cord-264884-ydkigome	746	5	-	-	HYPH
cord-264884-ydkigome	746	6	like	like	JJ
cord-264884-ydkigome	746	7	DNA	dna	NN
cord-264884-ydkigome	746	8	viruses	virus	NNS
cord-264884-ydkigome	746	9	,	,	,
cord-264884-ydkigome	746	10	however	however	RB
cord-264884-ydkigome	746	11	,	,	,
cord-264884-ydkigome	746	12	is	be	VBZ
cord-264884-ydkigome	746	13	thought	think	VBN
cord-264884-ydkigome	746	14	to	to	TO
cord-264884-ydkigome	746	15	be	be	VB
cord-264884-ydkigome	746	16	distinct	distinct	JJ
cord-264884-ydkigome	746	17	from	from	IN
cord-264884-ydkigome	746	18	that	that	DT
cord-264884-ydkigome	746	19	herpes	herpe	NNS
cord-264884-ydkigome	746	20	and	and	CC
cord-264884-ydkigome	746	21	poxviruses	poxvirus	NNS
cord-264884-ydkigome	746	22	and	and	CC
cord-264884-ydkigome	746	23	its	-PRON-	PRP$
cord-264884-ydkigome	746	24	DNA	dna	NN
cord-264884-ydkigome	746	25	polymerase	polymerase	NN
cord-264884-ydkigome	746	26	is	be	VBZ
cord-264884-ydkigome	746	27	clearly	clearly	RB
cord-264884-ydkigome	746	28	distinct	distinct	JJ
cord-264884-ydkigome	746	29	from	from	IN
cord-264884-ydkigome	746	30	polyndavirus	polyndavirus	NNP
cord-264884-ydkigome	746	31	.	.	.
cord-264884-ydkigome	747	1	It	-PRON-	PRP
cord-264884-ydkigome	747	2	is	be	VBZ
cord-264884-ydkigome	747	3	clear	clear	JJ
cord-264884-ydkigome	747	4	that	that	IN
cord-264884-ydkigome	747	5	related	related	JJ
cord-264884-ydkigome	747	6	elements	element	NNS
cord-264884-ydkigome	747	7	of	of	IN
cord-264884-ydkigome	747	8	all	all	PDT
cord-264884-ydkigome	747	9	these	these	DT
cord-264884-ydkigome	747	10	viruses	virus	NNS
cord-264884-ydkigome	747	11	can	can	MD
cord-264884-ydkigome	747	12	be	be	VB
cord-264884-ydkigome	747	13	found	find	VBN
cord-264884-ydkigome	747	14	in	in	IN
cord-264884-ydkigome	747	15	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	747	16	.	.	.
cord-264884-ydkigome	748	1	Overall	overall	RB
cord-264884-ydkigome	748	2	,	,	,
cord-264884-ydkigome	748	3	the	the	DT
cord-264884-ydkigome	748	4	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	748	5	,	,	,
cord-264884-ydkigome	748	6	like	like	IN
cord-264884-ydkigome	748	7	phage	phage	NN
cord-264884-ydkigome	748	8	,	,	,
cord-264884-ydkigome	748	9	also	also	RB
cord-264884-ydkigome	748	10	appear	appear	VBP
cord-264884-ydkigome	748	11	to	to	TO
cord-264884-ydkigome	748	12	be	be	VB
cord-264884-ydkigome	748	13	creating	create	VBG
cord-264884-ydkigome	748	14	genes	gene	NNS
cord-264884-ydkigome	748	15	in	in	IN
cord-264884-ydkigome	748	16	large	large	JJ
cord-264884-ydkigome	748	17	numbers	number	NNS
cord-264884-ydkigome	748	18	and	and	CC
cord-264884-ydkigome	748	19	they	-PRON-	PRP
cord-264884-ydkigome	748	20	encode	encode	VBP
cord-264884-ydkigome	748	21	many	many	JJ
cord-264884-ydkigome	748	22	genes	gene	NNS
cord-264884-ydkigome	748	23	unrelated	unrelated	JJ
cord-264884-ydkigome	748	24	to	to	IN
cord-264884-ydkigome	748	25	their	-PRON-	PRP$
cord-264884-ydkigome	748	26	host	host	NN
cord-264884-ydkigome	748	27	.	.	.
cord-264884-ydkigome	749	1	What	what	WP
cord-264884-ydkigome	749	2	then	then	RB
cord-264884-ydkigome	749	3	is	be	VBZ
cord-264884-ydkigome	749	4	the	the	DT
cord-264884-ydkigome	749	5	evolutionary	evolutionary	JJ
cord-264884-ydkigome	749	6	relationship	relationship	NN
cord-264884-ydkigome	749	7	that	that	WDT
cord-264884-ydkigome	749	8	links	link	VBZ
cord-264884-ydkigome	749	9	all	all	DT
cord-264884-ydkigome	749	10	of	of	IN
cord-264884-ydkigome	749	11	these	these	DT
cord-264884-ydkigome	749	12	seemingly	seemingly	RB
cord-264884-ydkigome	749	13	distinct	distinct	JJ
cord-264884-ydkigome	749	14	viruses	virus	NNS
cord-264884-ydkigome	749	15	?	?	.
cord-264884-ydkigome	750	1	As	as	IN
cord-264884-ydkigome	750	2	outlined	outline	VBN
cord-264884-ydkigome	750	3	above	above	RB
cord-264884-ydkigome	750	4	,	,	,
cord-264884-ydkigome	750	5	the	the	DT
cord-264884-ydkigome	750	6	pattern	pattern	NN
cord-264884-ydkigome	750	7	of	of	IN
cord-264884-ydkigome	750	8	evolution	evolution	NN
cord-264884-ydkigome	750	9	of	of	IN
cord-264884-ydkigome	750	10	dsDNA	dsdna	JJ
cord-264884-ydkigome	750	11	phage	phage	NN
cord-264884-ydkigome	750	12	involves	involve	VBZ
cord-264884-ydkigome	750	13	lots	lot	NNS
cord-264884-ydkigome	750	14	of	of	IN
cord-264884-ydkigome	750	15	exchange	exchange	NN
cord-264884-ydkigome	750	16	by	by	IN
cord-264884-ydkigome	750	17	recombination	recombination	NN
cord-264884-ydkigome	750	18	from	from	IN
cord-264884-ydkigome	750	19	a	a	DT
cord-264884-ydkigome	750	20	vast	vast	JJ
cord-264884-ydkigome	750	21	gene	gene	NN
cord-264884-ydkigome	750	22	pool	pool	NN
cord-264884-ydkigome	750	23	.	.	.
cord-264884-ydkigome	751	1	This	this	DT
cord-264884-ydkigome	751	2	pool	pool	NN
cord-264884-ydkigome	751	3	resembles	resemble	VBZ
cord-264884-ydkigome	751	4	a	a	DT
cord-264884-ydkigome	751	5	cloud	cloud	NN
cord-264884-ydkigome	751	6	from	from	IN
cord-264884-ydkigome	751	7	which	which	WDT
cord-264884-ydkigome	751	8	various	various	JJ
cord-264884-ydkigome	751	9	mosaic	mosaic	JJ
cord-264884-ydkigome	751	10	subelements	subelement	NNS
cord-264884-ydkigome	751	11	and	and	CC
cord-264884-ydkigome	751	12	substrategies	substrategie	NNS
cord-264884-ydkigome	751	13	are	be	VBP
cord-264884-ydkigome	751	14	assembled	assemble	VBN
cord-264884-ydkigome	751	15	to	to	TO
cord-264884-ydkigome	751	16	allow	allow	VB
cord-264884-ydkigome	751	17	viral	viral	JJ
cord-264884-ydkigome	751	18	gene	gene	NN
cord-264884-ydkigome	751	19	acquisition	acquisition	NN
cord-264884-ydkigome	751	20	and	and	CC
cord-264884-ydkigome	751	21	novelty	novelty	NN
cord-264884-ydkigome	751	22	(	(	-LRB-
cord-264884-ydkigome	751	23	Blum	Blum	NNP
cord-264884-ydkigome	751	24	et	et	NNP
cord-264884-ydkigome	751	25	al	al	NNP
cord-264884-ydkigome	751	26	.	.	.
cord-264884-ydkigome	752	1	,	,	,
cord-264884-ydkigome	752	2	2001	2001	CD
cord-264884-ydkigome	752	3	;	;	:
cord-264884-ydkigome	752	4	Benson	Benson	NNP
cord-264884-ydkigome	752	5	et	et	NNP
cord-264884-ydkigome	752	6	al	al	NNP
cord-264884-ydkigome	752	7	.	.	NNP
cord-264884-ydkigome	752	8	,	,	,
cord-264884-ydkigome	752	9	2004	2004	CD
cord-264884-ydkigome	752	10	)	)	-RRB-
cord-264884-ydkigome	752	11	.	.	.
cord-264884-ydkigome	753	1	Does	do	VBZ
cord-264884-ydkigome	753	2	such	such	PDT
cord-264884-ydkigome	753	3	a	a	DT
cord-264884-ydkigome	753	4	distributed	distribute	VBN
cord-264884-ydkigome	753	5	pattern	pattern	NN
cord-264884-ydkigome	753	6	of	of	IN
cord-264884-ydkigome	753	7	evolution	evolution	NN
cord-264884-ydkigome	753	8	and	and	CC
cord-264884-ydkigome	753	9	gene	gene	NN
cord-264884-ydkigome	753	10	novelty	novelty	NN
cord-264884-ydkigome	753	11	also	also	RB
cord-264884-ydkigome	753	12	apply	apply	VBP
cord-264884-ydkigome	753	13	to	to	IN
cord-264884-ydkigome	753	14	the	the	DT
cord-264884-ydkigome	753	15	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	753	16	?	?	.
cord-264884-ydkigome	754	1	Recently	recently	RB
cord-264884-ydkigome	754	2	,	,	,
cord-264884-ydkigome	754	3	another	another	DT
cord-264884-ydkigome	754	4	distinct	distinct	JJ
cord-264884-ydkigome	754	5	phycodnavirus	phycodnavirus	NN
cord-264884-ydkigome	754	6	has	have	VBZ
cord-264884-ydkigome	754	7	been	be	VBN
cord-264884-ydkigome	754	8	sequenced	sequence	VBN
cord-264884-ydkigome	754	9	:	:	:
cord-264884-ydkigome	754	10	coccolithovirus	coccolithovirus	NNP
cord-264884-ydkigome	754	11	(	(	-LRB-
cord-264884-ydkigome	754	12	EhV-86	EhV-86	NNP
cord-264884-ydkigome	754	13	)	)	-RRB-
cord-264884-ydkigome	754	14	(	(	-LRB-
cord-264884-ydkigome	754	15	Allen	Allen	NNP
cord-264884-ydkigome	754	16	et	et	NNP
cord-264884-ydkigome	754	17	al	al	NNP
cord-264884-ydkigome	754	18	.	.	NNP
cord-264884-ydkigome	754	19	,	,	,
cord-264884-ydkigome	754	20	2006a	2006a	CD
cord-264884-ydkigome	754	21	(	(	-LRB-
cord-264884-ydkigome	754	22	Allen	Allen	NNP
cord-264884-ydkigome	754	23	et	et	NNP
cord-264884-ydkigome	754	24	al	al	NNP
cord-264884-ydkigome	754	25	.	.	NNP
cord-264884-ydkigome	754	26	,	,	,
cord-264884-ydkigome	754	27	,	,	,
cord-264884-ydkigome	754	28	2006b	2006b	NNS
cord-264884-ydkigome	754	29	conserves	conserve	VBZ
cord-264884-ydkigome	754	30	only	only	RB
cord-264884-ydkigome	754	31	24	24	CD
cord-264884-ydkigome	754	32	core	core	NN
cord-264884-ydkigome	754	33	genes	gene	NNS
cord-264884-ydkigome	754	34	in	in	IN
cord-264884-ydkigome	754	35	common	common	JJ
cord-264884-ydkigome	754	36	with	with	IN
cord-264884-ydkigome	754	37	PBCV-1	PBCV-1	NNS
cord-264884-ydkigome	754	38	and	and	CC
cord-264884-ydkigome	754	39	is	be	VBZ
cord-264884-ydkigome	754	40	unique	unique	JJ
cord-264884-ydkigome	754	41	to	to	IN
cord-264884-ydkigome	754	42	the	the	DT
cord-264884-ydkigome	754	43	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	754	44	in	in	IN
cord-264884-ydkigome	754	45	that	that	IN
cord-264884-ydkigome	754	46	it	-PRON-	PRP
cord-264884-ydkigome	754	47	has	have	VBZ
cord-264884-ydkigome	754	48	acquired	acquire	VBN
cord-264884-ydkigome	754	49	six	six	CD
cord-264884-ydkigome	754	50	DNAdep	DNAdep	NNP
cord-264884-ydkigome	754	51	RNA	RNA	NNP
cord-264884-ydkigome	754	52	polymerase	polymerase	NN
cord-264884-ydkigome	754	53	subunit	subunit	NN
cord-264884-ydkigome	754	54	genes	gene	NNS
cord-264884-ydkigome	754	55	,	,	,
cord-264884-ydkigome	754	56	which	which	WDT
cord-264884-ydkigome	754	57	are	be	VBP
cord-264884-ydkigome	754	58	absent	absent	JJ
cord-264884-ydkigome	754	59	in	in	IN
cord-264884-ydkigome	754	60	all	all	DT
cord-264884-ydkigome	754	61	other	other	JJ
cord-264884-ydkigome	754	62	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	754	63	.	.	.
cord-264884-ydkigome	755	1	As	as	IN
cord-264884-ydkigome	755	2	RNA	RNA	NNP
cord-264884-ydkigome	755	3	polymerase	polymerase	NN
cord-264884-ydkigome	755	4	is	be	VBZ
cord-264884-ydkigome	755	5	considered	consider	VBN
cord-264884-ydkigome	755	6	a	a	DT
cord-264884-ydkigome	755	7	core	core	JJ
cord-264884-ydkigome	755	8	viral	viral	JJ
cord-264884-ydkigome	755	9	gene	gene	NN
cord-264884-ydkigome	755	10	function	function	NN
cord-264884-ydkigome	755	11	,	,	,
cord-264884-ydkigome	755	12	it	-PRON-	PRP
cord-264884-ydkigome	755	13	is	be	VBZ
cord-264884-ydkigome	755	14	clear	clear	JJ
cord-264884-ydkigome	755	15	that	that	IN
cord-264884-ydkigome	755	16	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	755	17	can	can	MD
cord-264884-ydkigome	755	18	alter	alter	VB
cord-264884-ydkigome	755	19	some	some	DT
cord-264884-ydkigome	755	20	very	very	RB
cord-264884-ydkigome	755	21	basic	basic	JJ
cord-264884-ydkigome	755	22	molecular	molecular	JJ
cord-264884-ydkigome	755	23	functions	function	NNS
cord-264884-ydkigome	755	24	during	during	IN
cord-264884-ydkigome	755	25	their	-PRON-	PRP$
cord-264884-ydkigome	755	26	evolution	evolution	NN
cord-264884-ydkigome	755	27	.	.	.
cord-264884-ydkigome	756	1	Oceanic	oceanic	JJ
cord-264884-ydkigome	756	2	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	756	3	are	be	VBP
cord-264884-ydkigome	756	4	thought	think	VBN
cord-264884-ydkigome	756	5	to	to	TO
cord-264884-ydkigome	756	6	have	have	VB
cord-264884-ydkigome	756	7	large	large	JJ
cord-264884-ydkigome	756	8	infl	infl	NN
cord-264884-ydkigome	756	9	uence	uence	NN
cord-264884-ydkigome	756	10	on	on	IN
cord-264884-ydkigome	756	11	the	the	DT
cord-264884-ydkigome	756	12	free	free	RB
cord-264884-ydkigome	756	13	-	-	HYPH
cord-264884-ydkigome	756	14	living	live	VBG
cord-264884-ydkigome	756	15	populations	population	NNS
cord-264884-ydkigome	756	16	of	of	IN
cord-264884-ydkigome	756	17	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	756	18	algae	algae	NN
cord-264884-ydkigome	756	19	,	,	,
cord-264884-ydkigome	756	20	such	such	JJ
cord-264884-ydkigome	756	21	as	as	IN
cord-264884-ydkigome	756	22	the	the	DT
cord-264884-ydkigome	756	23	termination	termination	NN
cord-264884-ydkigome	756	24	of	of	IN
cord-264884-ydkigome	756	25	algal	algal	JJ
cord-264884-ydkigome	756	26	blooms	bloom	NNS
cord-264884-ydkigome	756	27	reported	report	VBN
cord-264884-ydkigome	756	28	for	for	IN
cord-264884-ydkigome	756	29	Emilian	Emilian	NNP
cord-264884-ydkigome	756	30	Huxley	Huxley	NNP
cord-264884-ydkigome	756	31	virus	virus	NN
cord-264884-ydkigome	756	32	(	(	-LRB-
cord-264884-ydkigome	756	33	Martinez	Martinez	NNP
cord-264884-ydkigome	756	34	et	et	NNP
cord-264884-ydkigome	756	35	al	al	NNP
cord-264884-ydkigome	756	36	.	.	NNP
cord-264884-ydkigome	756	37	,	,	,
cord-264884-ydkigome	756	38	2007	2007	CD
cord-264884-ydkigome	756	39	;	;	:
cord-264884-ydkigome	756	40	Schroeder	Schroeder	NNP
cord-264884-ydkigome	756	41	et	et	NNP
cord-264884-ydkigome	756	42	al	al	NNP
cord-264884-ydkigome	756	43	.	.	NNP
cord-264884-ydkigome	756	44	,	,	,
cord-264884-ydkigome	756	45	2003	2003	CD
cord-264884-ydkigome	756	46	)	)	-RRB-
cord-264884-ydkigome	756	47	.	.	.
cord-264884-ydkigome	757	1	However	however	RB
cord-264884-ydkigome	757	2	,	,	,
cord-264884-ydkigome	757	3	not	not	RB
cord-264884-ydkigome	757	4	all	all	DT
cord-264884-ydkigome	757	5	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	757	6	are	be	VBP
cord-264884-ydkigome	757	7	lytic	lytic	JJ
cord-264884-ydkigome	757	8	.	.	.
cord-264884-ydkigome	758	1	Another	another	DT
cord-264884-ydkigome	758	2	lineage	lineage	NN
cord-264884-ydkigome	758	3	of	of	IN
cord-264884-ydkigome	758	4	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	758	5	is	be	VBZ
cord-264884-ydkigome	758	6	represented	represent	VBN
cord-264884-ydkigome	758	7	by	by	IN
cord-264884-ydkigome	758	8	two	two	CD
cord-264884-ydkigome	758	9	viruses	virus	NNS
cord-264884-ydkigome	758	10	of	of	IN
cord-264884-ydkigome	758	11	fi	fi	NNP
cord-264884-ydkigome	758	12	lamentous	lamentous	NNP
cord-264884-ydkigome	758	13	brown	brown	NNP
cord-264884-ydkigome	758	14	algae	algae	NN
cord-264884-ydkigome	758	15	,	,	,
cord-264884-ydkigome	758	16	EsV-1	EsV-1	NNP
cord-264884-ydkigome	758	17	and	and	CC
cord-264884-ydkigome	758	18	FirrV-1	FirrV-1	NNP
cord-264884-ydkigome	758	19	(	(	-LRB-
cord-264884-ydkigome	758	20	Delaroque	Delaroque	NNP
cord-264884-ydkigome	758	21	et	et	FW
cord-264884-ydkigome	758	22	al	al	NNP
cord-264884-ydkigome	758	23	.	.	NNP
cord-264884-ydkigome	758	24	,	,	,
cord-264884-ydkigome	758	25	2003	2003	CD
cord-264884-ydkigome	758	26	)	)	-RRB-
cord-264884-ydkigome	758	27	.	.	.
cord-264884-ydkigome	759	1	Unlike	unlike	IN
cord-264884-ydkigome	759	2	the	the	DT
cord-264884-ydkigome	759	3	lytic	lytic	JJ
cord-264884-ydkigome	759	4	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	759	5	noted	note	VBN
cord-264884-ydkigome	759	6	above	above	RB
cord-264884-ydkigome	759	7	,	,	,
cord-264884-ydkigome	759	8	these	these	DT
cord-264884-ydkigome	759	9	two	two	CD
cord-264884-ydkigome	759	10	viruses	virus	NNS
cord-264884-ydkigome	759	11	are	be	VBP
cord-264884-ydkigome	759	12	"	"	``
cord-264884-ydkigome	759	13	temperate	temperate	JJ
cord-264884-ydkigome	759	14	phage	phage	NN
cord-264884-ydkigome	759	15	"	"	''
cord-264884-ydkigome	759	16	like	like	UH
cord-264884-ydkigome	759	17	.	.	.
cord-264884-ydkigome	760	1	That	that	DT
cord-264884-ydkigome	760	2	is	is	RB
cord-264884-ydkigome	760	3	they	-PRON-	PRP
cord-264884-ydkigome	760	4	exist	exist	VBP
cord-264884-ydkigome	760	5	as	as	IN
cord-264884-ydkigome	760	6	silent	silent	JJ
cord-264884-ydkigome	760	7	viruses	virus	NNS
cord-264884-ydkigome	760	8	whose	whose	WP$
cord-264884-ydkigome	760	9	DNA	dna	NN
cord-264884-ydkigome	760	10	is	be	VBZ
cord-264884-ydkigome	760	11	integrated	integrate	VBN
cord-264884-ydkigome	760	12	into	into	IN
cord-264884-ydkigome	760	13	the	the	DT
cord-264884-ydkigome	760	14	germlines	germline	NNS
cord-264884-ydkigome	760	15	of	of	IN
cord-264884-ydkigome	760	16	their	-PRON-	PRP$
cord-264884-ydkigome	760	17	host	host	NN
cord-264884-ydkigome	760	18	.	.	.
cord-264884-ydkigome	761	1	In	in	IN
cord-264884-ydkigome	761	2	this	this	DT
cord-264884-ydkigome	761	3	,	,	,
cord-264884-ydkigome	761	4	they	-PRON-	PRP
cord-264884-ydkigome	761	5	are	be	VBP
cord-264884-ydkigome	761	6	unique	unique	JJ
cord-264884-ydkigome	761	7	to	to	IN
cord-264884-ydkigome	761	8	all	all	DT
cord-264884-ydkigome	761	9	known	know	VBN
cord-264884-ydkigome	761	10	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	761	11	DNA	dna	NN
cord-264884-ydkigome	761	12	viruses	virus	NNS
cord-264884-ydkigome	761	13	;	;	:
cord-264884-ydkigome	761	14	host	host	NN
cord-264884-ydkigome	761	15	chromosome	chromosome	NN
cord-264884-ydkigome	761	16	integration	integration	NN
cord-264884-ydkigome	761	17	is	be	VBZ
cord-264884-ydkigome	761	18	a	a	DT
cord-264884-ydkigome	761	19	normal	normal	JJ
cord-264884-ydkigome	761	20	part	part	NN
cord-264884-ydkigome	761	21	of	of	IN
cord-264884-ydkigome	761	22	their	-PRON-	PRP$
cord-264884-ydkigome	761	23	persistent	persistent	JJ
cord-264884-ydkigome	761	24	life	life	NN
cord-264884-ydkigome	761	25	strategy	strategy	NN
cord-264884-ydkigome	761	26	.	.	.
cord-264884-ydkigome	762	1	EsV-1	EsV-1	NNP
cord-264884-ydkigome	762	2	has	have	VBZ
cord-264884-ydkigome	762	3	a	a	DT
cord-264884-ydkigome	762	4	335	335	CD
cord-264884-ydkigome	762	5	593-bp	593-bp	CD
cord-264884-ydkigome	762	6	genome	genome	NN
cord-264884-ydkigome	762	7	and	and	CC
cord-264884-ydkigome	762	8	encodes	encode	VBZ
cord-264884-ydkigome	762	9	231	231	CD
cord-264884-ydkigome	762	10	likely	likely	JJ
cord-264884-ydkigome	762	11	genes	gene	NNS
cord-264884-ydkigome	762	12	(	(	-LRB-
cord-264884-ydkigome	762	13	Delaroque	Delaroque	NNP
cord-264884-ydkigome	762	14	et	et	FW
cord-264884-ydkigome	762	15	al	al	NNP
cord-264884-ydkigome	762	16	.	.	NNP
cord-264884-ydkigome	762	17	,	,	,
cord-264884-ydkigome	762	18	2001	2001	CD
cord-264884-ydkigome	762	19	)	)	-RRB-
cord-264884-ydkigome	762	20	.	.	.
cord-264884-ydkigome	763	1	These	these	DT
cord-264884-ydkigome	763	2	genes	gene	NNS
cord-264884-ydkigome	763	3	are	be	VBP
cord-264884-ydkigome	763	4	mostly	mostly	RB
cord-264884-ydkigome	763	5	unique	unique	JJ
cord-264884-ydkigome	763	6	and	and	CC
cord-264884-ydkigome	763	7	only	only	RB
cord-264884-ydkigome	763	8	28	28	CD
cord-264884-ydkigome	763	9	are	be	VBP
cord-264884-ydkigome	763	10	clearly	clearly	RB
cord-264884-ydkigome	763	11	related	relate	VBN
cord-264884-ydkigome	763	12	to	to	IN
cord-264884-ydkigome	763	13	PBCV-1	PBCV-1	NNP
cord-264884-ydkigome	763	14	genes	gene	NNS
cord-264884-ydkigome	763	15	.	.	.
cord-264884-ydkigome	764	1	The	the	DT
cord-264884-ydkigome	764	2	gene	gene	NN
cord-264884-ydkigome	764	3	differences	difference	NNS
cord-264884-ydkigome	764	4	include	include	VBP
cord-264884-ydkigome	764	5	many	many	JJ
cord-264884-ydkigome	764	6	replication	replication	NN
cord-264884-ydkigome	764	7	genes	gene	NNS
cord-264884-ydkigome	764	8	and	and	CC
cord-264884-ydkigome	764	9	their	-PRON-	PRP$
cord-264884-ydkigome	764	10	gene	gene	NN
cord-264884-ydkigome	764	11	order	order	NN
cord-264884-ydkigome	764	12	is	be	VBZ
cord-264884-ydkigome	764	13	completely	completely	RB
cord-264884-ydkigome	764	14	different	different	JJ
cord-264884-ydkigome	764	15	.	.	.
cord-264884-ydkigome	765	1	Like	like	IN
cord-264884-ydkigome	765	2	the	the	DT
cord-264884-ydkigome	765	3	temperate	temperate	JJ
cord-264884-ydkigome	765	4	phage	phage	NN
cord-264884-ydkigome	765	5	-	-	HYPH
cord-264884-ydkigome	765	6	host	host	NN
cord-264884-ydkigome	765	7	evolutionary	evolutionary	JJ
cord-264884-ydkigome	765	8	relationship	relationship	NN
cord-264884-ydkigome	765	9	outlined	outline	VBN
cord-264884-ydkigome	765	10	above	above	RB
cord-264884-ydkigome	765	11	,	,	,
cord-264884-ydkigome	765	12	it	-PRON-	PRP
cord-264884-ydkigome	765	13	would	would	MD
cord-264884-ydkigome	765	14	be	be	VB
cord-264884-ydkigome	765	15	most	most	RBS
cord-264884-ydkigome	765	16	interesting	interesting	JJ
cord-264884-ydkigome	765	17	to	to	TO
cord-264884-ydkigome	765	18	understand	understand	VB
cord-264884-ydkigome	765	19	how	how	WRB
cord-264884-ydkigome	765	20	the	the	DT
cord-264884-ydkigome	765	21	integration	integration	NN
cord-264884-ydkigome	765	22	of	of	IN
cord-264884-ydkigome	765	23	these	these	DT
cord-264884-ydkigome	765	24	large	large	JJ
cord-264884-ydkigome	765	25	DNA	dna	NN
cord-264884-ydkigome	765	26	viruses	virus	NNS
cord-264884-ydkigome	765	27	has	have	VBZ
cord-264884-ydkigome	765	28	affected	affect	VBN
cord-264884-ydkigome	765	29	host	host	NN
cord-264884-ydkigome	765	30	evolution	evolution	NN
cord-264884-ydkigome	765	31	.	.	.
cord-264884-ydkigome	766	1	Thus	thus	RB
cord-264884-ydkigome	766	2	,	,	,
cord-264884-ydkigome	766	3	the	the	DT
cord-264884-ydkigome	766	4	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	766	5	appear	appear	VBP
cord-264884-ydkigome	766	6	to	to	TO
cord-264884-ydkigome	766	7	represent	represent	VB
cord-264884-ydkigome	766	8	a	a	DT
cord-264884-ydkigome	766	9	basal	basal	NN
cord-264884-ydkigome	766	10	but	but	CC
cord-264884-ydkigome	766	11	diverse	diverse	JJ
cord-264884-ydkigome	766	12	viral	viral	JJ
cord-264884-ydkigome	766	13	lineage	lineage	NN
cord-264884-ydkigome	766	14	that	that	WDT
cord-264884-ydkigome	766	15	has	have	VBZ
cord-264884-ydkigome	766	16	both	both	DT
cord-264884-ydkigome	766	17	acute	acute	JJ
cord-264884-ydkigome	766	18	and	and	CC
cord-264884-ydkigome	766	19	persistent	persistent	JJ
cord-264884-ydkigome	766	20	lifestyle	lifestyle	NN
cord-264884-ydkigome	766	21	and	and	CC
cord-264884-ydkigome	766	22	have	have	VBP
cord-264884-ydkigome	766	23	some	some	DT
cord-264884-ydkigome	766	24	clear	clear	JJ
cord-264884-ydkigome	766	25	relationships	relationship	NNS
cord-264884-ydkigome	766	26	to	to	IN
cord-264884-ydkigome	766	27	most	most	RBS
cord-264884-ydkigome	766	28	large	large	JJ
cord-264884-ydkigome	766	29	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	766	30	DNA	dna	NN
cord-264884-ydkigome	766	31	viruses	virus	NNS
cord-264884-ydkigome	766	32	and	and	CC
cord-264884-ydkigome	766	33	many	many	JJ
cord-264884-ydkigome	766	34	phage	phage	NN
cord-264884-ydkigome	766	35	.	.	.
cord-264884-ydkigome	767	1	The	the	DT
cord-264884-ydkigome	767	2	phycodnavirus	phycodnavirus	JJ
cord-264884-ydkigome	767	3	exemplar	exemplar	NN
cord-264884-ydkigome	767	4	above	above	RB
cord-264884-ydkigome	767	5	should	should	MD
cord-264884-ydkigome	767	6	leave	leave	VB
cord-264884-ydkigome	767	7	us	-PRON-	PRP
cord-264884-ydkigome	767	8	with	with	IN
cord-264884-ydkigome	767	9	several	several	JJ
cord-264884-ydkigome	767	10	impressions	impression	NNS
cord-264884-ydkigome	767	11	regarding	regard	VBG
cord-264884-ydkigome	767	12	the	the	DT
cord-264884-ydkigome	767	13	nature	nature	NN
cord-264884-ydkigome	767	14	and	and	CC
cord-264884-ydkigome	767	15	evolution	evolution	NN
cord-264884-ydkigome	767	16	of	of	IN
cord-264884-ydkigome	767	17	these	these	DT
cord-264884-ydkigome	767	18	large	large	JJ
cord-264884-ydkigome	767	19	and	and	CC
cord-264884-ydkigome	767	20	ubiquitous	ubiquitous	JJ
cord-264884-ydkigome	767	21	DNA	dna	NN
cord-264884-ydkigome	767	22	viruses	virus	NNS
cord-264884-ydkigome	767	23	of	of	IN
cord-264884-ydkigome	767	24	algae	algae	NN
cord-264884-ydkigome	767	25	,	,	,
cord-264884-ydkigome	767	26	an	an	DT
cord-264884-ydkigome	767	27	early	early	JJ
cord-264884-ydkigome	767	28	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	767	29	host	host	NN
cord-264884-ydkigome	767	30	.	.	.
cord-264884-ydkigome	768	1	They	-PRON-	PRP
cord-264884-ydkigome	768	2	show	show	VBP
cord-264884-ydkigome	768	3	clear	clear	JJ
cord-264884-ydkigome	768	4	linkages	linkage	NNS
cord-264884-ydkigome	768	5	by	by	IN
cord-264884-ydkigome	768	6	structure	structure	NN
cord-264884-ydkigome	768	7	and	and	CC
cord-264884-ydkigome	768	8	function	function	NN
cord-264884-ydkigome	768	9	to	to	IN
cord-264884-ydkigome	768	10	both	both	CC
cord-264884-ydkigome	768	11	phage	phage	NN
cord-264884-ydkigome	768	12	and	and	CC
cord-264884-ydkigome	768	13	various	various	JJ
cord-264884-ydkigome	768	14	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	768	15	DNA	dna	NN
cord-264884-ydkigome	768	16	viruses	virus	NNS
cord-264884-ydkigome	768	17	.	.	.
cord-264884-ydkigome	769	1	They	-PRON-	PRP
cord-264884-ydkigome	769	2	also	also	RB
cord-264884-ydkigome	769	3	show	show	VBP
cord-264884-ydkigome	769	4	major	major	JJ
cord-264884-ydkigome	769	5	variation	variation	NN
cord-264884-ydkigome	769	6	and	and	CC
cord-264884-ydkigome	769	7	novelty	novelty	NN
cord-264884-ydkigome	769	8	in	in	IN
cord-264884-ydkigome	769	9	their	-PRON-	PRP$
cord-264884-ydkigome	769	10	own	own	JJ
cord-264884-ydkigome	769	11	genetic	genetic	JJ
cord-264884-ydkigome	769	12	composition	composition	NN
cord-264884-ydkigome	769	13	,	,	,
cord-264884-ydkigome	769	14	including	include	VBG
cord-264884-ydkigome	769	15	their	-PRON-	PRP$
cord-264884-ydkigome	769	16	core	core	NN
cord-264884-ydkigome	769	17	genes	gene	NNS
cord-264884-ydkigome	769	18	.	.	.
cord-264884-ydkigome	770	1	In	in	IN
cord-264884-ydkigome	770	2	addition	addition	NN
cord-264884-ydkigome	770	3	,	,	,
cord-264884-ydkigome	770	4	they	-PRON-	PRP
cord-264884-ydkigome	770	5	show	show	VBP
cord-264884-ydkigome	770	6	clear	clear	JJ
cord-264884-ydkigome	770	7	relationships	relationship	NNS
cord-264884-ydkigome	770	8	to	to	IN
cord-264884-ydkigome	770	9	distinct	distinct	JJ
cord-264884-ydkigome	770	10	and	and	CC
cord-264884-ydkigome	770	11	seemingly	seemingly	RB
cord-264884-ydkigome	770	12	separate	separate	JJ
cord-264884-ydkigome	770	13	viral	viral	JJ
cord-264884-ydkigome	770	14	lineages	lineage	NNS
cord-264884-ydkigome	770	15	(	(	-LRB-
cord-264884-ydkigome	770	16	adenoviruses	adenovirus	NNS
cord-264884-ydkigome	770	17	,	,	,
cord-264884-ydkigome	770	18	herpesviruses	herpesviruses	NNP
cord-264884-ydkigome	770	19	,	,	,
cord-264884-ydkigome	770	20	poxviruses	poxvirus	NNS
cord-264884-ydkigome	770	21	,	,	,
cord-264884-ydkigome	770	22	iridoviruses	iridoviruses	NNP
cord-264884-ydkigome	770	23	)	)	-RRB-
cord-264884-ydkigome	770	24	.	.	.
cord-264884-ydkigome	771	1	The	the	DT
cord-264884-ydkigome	771	2	picture	picture	NN
cord-264884-ydkigome	771	3	we	-PRON-	PRP
cord-264884-ydkigome	771	4	are	be	VBP
cord-264884-ydkigome	771	5	left	leave	VBN
cord-264884-ydkigome	771	6	with	with	IN
cord-264884-ydkigome	771	7	is	be	VBZ
cord-264884-ydkigome	771	8	that	that	IN
cord-264884-ydkigome	771	9	they	-PRON-	PRP
cord-264884-ydkigome	771	10	seem	seem	VBP
cord-264884-ydkigome	771	11	to	to	TO
cord-264884-ydkigome	771	12	resemble	resemble	VB
cord-264884-ydkigome	771	13	phage	phage	NN
cord-264884-ydkigome	771	14	evolution	evolution	NN
cord-264884-ydkigome	771	15	in	in	IN
cord-264884-ydkigome	771	16	that	that	IN
cord-264884-ydkigome	771	17	they	-PRON-	PRP
cord-264884-ydkigome	771	18	appear	appear	VBP
cord-264884-ydkigome	771	19	to	to	TO
cord-264884-ydkigome	771	20	have	have	VB
cord-264884-ydkigome	771	21	evolved	evolve	VBN
cord-264884-ydkigome	771	22	from	from	IN
cord-264884-ydkigome	771	23	a	a	DT
cord-264884-ydkigome	771	24	diverse	diverse	JJ
cord-264884-ydkigome	771	25	pool	pool	NN
cord-264884-ydkigome	771	26	that	that	WDT
cord-264884-ydkigome	771	27	has	have	VBZ
cord-264884-ydkigome	771	28	exchanged	exchange	VBN
cord-264884-ydkigome	771	29	many	many	JJ
cord-264884-ydkigome	771	30	basic	basic	JJ
cord-264884-ydkigome	771	31	viral	viral	JJ
cord-264884-ydkigome	771	32	features	feature	NNS
cord-264884-ydkigome	771	33	and	and	CC
cord-264884-ydkigome	771	34	created	create	VBD
cord-264884-ydkigome	771	35	many	many	JJ
cord-264884-ydkigome	771	36	new	new	JJ
cord-264884-ydkigome	771	37	genes	gene	NNS
cord-264884-ydkigome	771	38	.	.	.
cord-264884-ydkigome	772	1	This	this	DT
cord-264884-ydkigome	772	2	view	view	NN
cord-264884-ydkigome	772	3	,	,	,
cord-264884-ydkigome	772	4	however	however	RB
cord-264884-ydkigome	772	5	,	,	,
cord-264884-ydkigome	772	6	contrasts	contrast	VBZ
cord-264884-ydkigome	772	7	sharply	sharply	RB
cord-264884-ydkigome	772	8	with	with	IN
cord-264884-ydkigome	772	9	the	the	DT
cord-264884-ydkigome	772	10	work	work	NN
cord-264884-ydkigome	772	11	of	of	IN
cord-264884-ydkigome	772	12	Iyer	Iyer	NNP
cord-264884-ydkigome	772	13	et	et	NNP
cord-264884-ydkigome	772	14	al	al	NNP
cord-264884-ydkigome	772	15	.	.	.
cord-264884-ydkigome	773	1	(	(	-LRB-
cord-264884-ydkigome	773	2	2001	2001	CD
cord-264884-ydkigome	773	3	Iyer	Iyer	NNP
cord-264884-ydkigome	773	4	et	et	NNP
cord-264884-ydkigome	773	5	al	al	NNP
cord-264884-ydkigome	773	6	.	.	.
cord-264884-ydkigome	774	1	(	(	-LRB-
cord-264884-ydkigome	774	2	,	,	,
cord-264884-ydkigome	774	3	2006	2006	CD
cord-264884-ydkigome	774	4	.	.	.
cord-264884-ydkigome	775	1	By	by	IN
cord-264884-ydkigome	775	2	considering	consider	VBG
cord-264884-ydkigome	775	3	the	the	DT
cord-264884-ydkigome	775	4	small	small	JJ
cord-264884-ydkigome	775	5	number	number	NN
cord-264884-ydkigome	775	6	of	of	IN
cord-264884-ydkigome	775	7	conserved	conserved	JJ
cord-264884-ydkigome	775	8	genes	gene	NNS
cord-264884-ydkigome	775	9	in	in	IN
cord-264884-ydkigome	775	10	four	four	CD
cord-264884-ydkigome	775	11	families	family	NNS
cord-264884-ydkigome	775	12	of	of	IN
cord-264884-ydkigome	775	13	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	775	14	DNA	dna	NN
cord-264884-ydkigome	775	15	viruses	virus	NNS
cord-264884-ydkigome	775	16	(	(	-LRB-
cord-264884-ydkigome	775	17	poxviruses	poxvirus	NNS
cord-264884-ydkigome	775	18	,	,	,
cord-264884-ydkigome	775	19	asfarviruses	asfarviruse	NNS
cord-264884-ydkigome	775	20	,	,	,
cord-264884-ydkigome	775	21	iridoviruses	iridoviruses	NNPS
cord-264884-ydkigome	775	22	,	,	,
cord-264884-ydkigome	775	23	phycodnaviruses	phycodnaviruses	NNP
cord-264884-ydkigome	775	24	)	)	-RRB-
cord-264884-ydkigome	775	25	,	,	,
cord-264884-ydkigome	775	26	they	-PRON-	PRP
cord-264884-ydkigome	775	27	suggest	suggest	VBP
cord-264884-ydkigome	775	28	that	that	IN
cord-264884-ydkigome	775	29	these	these	DT
cord-264884-ydkigome	775	30	viruses	virus	NNS
cord-264884-ydkigome	775	31	are	be	VBP
cord-264884-ydkigome	775	32	monophyletic	monophyletic	JJ
cord-264884-ydkigome	775	33	,	,	,
cord-264884-ydkigome	775	34	evolving	evolve	VBG
cord-264884-ydkigome	775	35	from	from	IN
cord-264884-ydkigome	775	36	a	a	DT
cord-264884-ydkigome	775	37	common	common	JJ
cord-264884-ydkigome	775	38	nucleo	nucleo	JJ
cord-264884-ydkigome	775	39	-	-	JJ
cord-264884-ydkigome	775	40	cytoplasmic	cytoplasmic	JJ
cord-264884-ydkigome	775	41	large	large	JJ
cord-264884-ydkigome	775	42	DNA	dna	NN
cord-264884-ydkigome	775	43	virus	virus	NN
cord-264884-ydkigome	775	44	(	(	-LRB-
cord-264884-ydkigome	775	45	NCLDV	NCLDV	NNP
cord-264884-ydkigome	775	46	)	)	-RRB-
cord-264884-ydkigome	775	47	with	with	IN
cord-264884-ydkigome	775	48	an	an	DT
cord-264884-ydkigome	775	49	icosahedral	icosahedral	JJ
cord-264884-ydkigome	775	50	capsid	capsid	NN
cord-264884-ydkigome	775	51	.	.	.
cord-264884-ydkigome	776	1	Given	give	VBN
cord-264884-ydkigome	776	2	the	the	DT
cord-264884-ydkigome	776	3	above	above	JJ
cord-264884-ydkigome	776	4	information	information	NN
cord-264884-ydkigome	776	5	,	,	,
cord-264884-ydkigome	776	6	I	-PRON-	PRP
cord-264884-ydkigome	776	7	fi	fi	VBP
cord-264884-ydkigome	776	8	nd	nd	NNP
cord-264884-ydkigome	776	9	this	this	DT
cord-264884-ydkigome	776	10	view	view	VBP
cord-264884-ydkigome	776	11	unhelpful	unhelpful	JJ
cord-264884-ydkigome	776	12	and	and	CC
cord-264884-ydkigome	776	13	possibly	possibly	RB
cord-264884-ydkigome	776	14	confusing	confusing	JJ
cord-264884-ydkigome	776	15	.	.	.
cord-264884-ydkigome	777	1	It	-PRON-	PRP
cord-264884-ydkigome	777	2	has	have	VBZ
cord-264884-ydkigome	777	3	numerous	numerous	JJ
cord-264884-ydkigome	777	4	problems	problem	NNS
cord-264884-ydkigome	777	5	.	.	.
cord-264884-ydkigome	778	1	The	the	DT
cord-264884-ydkigome	778	2	main	main	JJ
cord-264884-ydkigome	778	3	problem	problem	NN
cord-264884-ydkigome	778	4	is	be	VBZ
cord-264884-ydkigome	778	5	that	that	IN
cord-264884-ydkigome	778	6	it	-PRON-	PRP
cord-264884-ydkigome	778	7	fails	fail	VBZ
cord-264884-ydkigome	778	8	to	to	TO
cord-264884-ydkigome	778	9	acknowledge	acknowledge	VB
cord-264884-ydkigome	778	10	the	the	DT
cord-264884-ydkigome	778	11	clear	clear	JJ
cord-264884-ydkigome	778	12	link	link	NN
cord-264884-ydkigome	778	13	between	between	IN
cord-264884-ydkigome	778	14	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	778	15	and	and	CC
cord-264884-ydkigome	778	16	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	778	17	viruses	virus	NNS
cord-264884-ydkigome	778	18	.	.	.
cord-264884-ydkigome	779	1	Furthermore	furthermore	RB
cord-264884-ydkigome	779	2	,	,	,
cord-264884-ydkigome	779	3	by	by	IN
cord-264884-ydkigome	779	4	focussing	focusse	VBG
cord-264884-ydkigome	779	5	on	on	IN
cord-264884-ydkigome	779	6	a	a	DT
cord-264884-ydkigome	779	7	small	small	JJ
cord-264884-ydkigome	779	8	set	set	NN
cord-264884-ydkigome	779	9	of	of	IN
cord-264884-ydkigome	779	10	related	related	JJ
cord-264884-ydkigome	779	11	genes	gene	NNS
cord-264884-ydkigome	779	12	,	,	,
cord-264884-ydkigome	779	13	it	-PRON-	PRP
cord-264884-ydkigome	779	14	represents	represent	VBZ
cord-264884-ydkigome	779	15	a	a	DT
cord-264884-ydkigome	779	16	traditional	traditional	JJ
cord-264884-ydkigome	779	17	perspective	perspective	NN
cord-264884-ydkigome	779	18	as	as	IN
cord-264884-ydkigome	779	19	found	find	VBN
cord-264884-ydkigome	779	20	in	in	IN
cord-264884-ydkigome	779	21	evolutionary	evolutionary	JJ
cord-264884-ydkigome	779	22	biology	biology	NN
cord-264884-ydkigome	779	23	that	that	WDT
cord-264884-ydkigome	779	24	assumes	assume	VBZ
cord-264884-ydkigome	779	25	a	a	DT
cord-264884-ydkigome	779	26	common	common	JJ
cord-264884-ydkigome	779	27	(	(	-LRB-
cord-264884-ydkigome	779	28	fi	fi	NNP
cord-264884-ydkigome	779	29	ttest	ttest	NNP
cord-264884-ydkigome	779	30	)	)	-RRB-
cord-264884-ydkigome	779	31	linear	linear	JJ
cord-264884-ydkigome	779	32	lineage	lineage	NN
cord-264884-ydkigome	779	33	,	,	,
cord-264884-ydkigome	779	34	not	not	RB
cord-264884-ydkigome	779	35	a	a	DT
cord-264884-ydkigome	779	36	cloud	cloud	NN
cord-264884-ydkigome	779	37	,	,	,
cord-264884-ydkigome	779	38	cooperative	cooperative	JJ
cord-264884-ydkigome	779	39	,	,	,
cord-264884-ydkigome	779	40	or	or	CC
cord-264884-ydkigome	779	41	mosaic	mosaic	JJ
cord-264884-ydkigome	779	42	pool	pool	NN
cord-264884-ydkigome	779	43	as	as	IN
cord-264884-ydkigome	779	44	the	the	DT
cord-264884-ydkigome	779	45	main	main	JJ
cord-264884-ydkigome	779	46	source	source	NN
cord-264884-ydkigome	779	47	of	of	IN
cord-264884-ydkigome	779	48	novelty	novelty	NN
cord-264884-ydkigome	779	49	resulting	result	VBG
cord-264884-ydkigome	779	50	in	in	IN
cord-264884-ydkigome	779	51	the	the	DT
cord-264884-ydkigome	779	52	matrix	matrix	NN
cord-264884-ydkigome	779	53	pattern	pattern	NN
cord-264884-ydkigome	779	54	of	of	IN
cord-264884-ydkigome	779	55	virus	virus	NN
cord-264884-ydkigome	779	56	evolution	evolution	NN
cord-264884-ydkigome	779	57	.	.	.
cord-264884-ydkigome	780	1	The	the	DT
cord-264884-ydkigome	780	2	virosphere	virosphere	NN
cord-264884-ydkigome	780	3	is	be	VBZ
cord-264884-ydkigome	780	4	clearly	clearly	RB
cord-264884-ydkigome	780	5	not	not	RB
cord-264884-ydkigome	780	6	disconnected	disconnected	JJ
cord-264884-ydkigome	780	7	from	from	IN
cord-264884-ydkigome	780	8	itself	-PRON-	PRP
cord-264884-ydkigome	780	9	,	,	,
cord-264884-ydkigome	780	10	but	but	CC
cord-264884-ydkigome	780	11	it	-PRON-	PRP
cord-264884-ydkigome	780	12	is	be	VBZ
cord-264884-ydkigome	780	13	also	also	RB
cord-264884-ydkigome	780	14	clearly	clearly	RB
cord-264884-ydkigome	780	15	not	not	RB
cord-264884-ydkigome	780	16	a	a	DT
cord-264884-ydkigome	780	17	linear	linear	JJ
cord-264884-ydkigome	780	18	or	or	CC
cord-264884-ydkigome	780	19	tree	tree	NN
cord-264884-ydkigome	780	20	-	-	HYPH
cord-264884-ydkigome	780	21	like	like	JJ
cord-264884-ydkigome	780	22	evolutionary	evolutionary	JJ
cord-264884-ydkigome	780	23	system	system	NN
cord-264884-ydkigome	780	24	as	as	IN
cord-264884-ydkigome	780	25	suggested	suggest	VBN
cord-264884-ydkigome	780	26	above	above	RB
cord-264884-ydkigome	780	27	.	.	.
cord-264884-ydkigome	781	1	We	-PRON-	PRP
cord-264884-ydkigome	781	2	must	must	MD
cord-264884-ydkigome	781	3	learn	learn	VB
cord-264884-ydkigome	781	4	to	to	TO
cord-264884-ydkigome	781	5	think	think	VB
cord-264884-ydkigome	781	6	of	of	IN
cord-264884-ydkigome	781	7	virus	virus	NN
cord-264884-ydkigome	781	8	evolution	evolution	NN
cord-264884-ydkigome	781	9	in	in	IN
cord-264884-ydkigome	781	10	its	-PRON-	PRP$
cord-264884-ydkigome	781	11	own	own	JJ
cord-264884-ydkigome	781	12	terms	term	NNS
cord-264884-ydkigome	781	13	;	;	:
cord-264884-ydkigome	781	14	fuzzy	fuzzy	JJ
cord-264884-ydkigome	781	15	,	,	,
cord-264884-ydkigome	781	16	mixed	mixed	JJ
cord-264884-ydkigome	781	17	,	,	,
cord-264884-ydkigome	781	18	reticulated	reticulated	JJ
cord-264884-ydkigome	781	19	,	,	,
cord-264884-ydkigome	781	20	and	and	CC
cord-264884-ydkigome	781	21	cloud	cloud	NN
cord-264884-ydkigome	781	22	-	-	HYPH
cord-264884-ydkigome	781	23	like	like	JJ
cord-264884-ydkigome	781	24	.	.	.
cord-264884-ydkigome	782	1	As	as	IN
cord-264884-ydkigome	782	2	mentioned	mention	VBN
cord-264884-ydkigome	782	3	in	in	IN
cord-264884-ydkigome	782	4	the	the	DT
cord-264884-ydkigome	782	5	phage	phage	NN
cord-264884-ydkigome	782	6	section	section	NN
cord-264884-ydkigome	782	7	,	,	,
cord-264884-ydkigome	782	8	there	there	EX
cord-264884-ydkigome	782	9	have	have	VBP
cord-264884-ydkigome	782	10	been	be	VBN
cord-264884-ydkigome	782	11	various	various	JJ
cord-264884-ydkigome	782	12	publications	publication	NNS
cord-264884-ydkigome	782	13	that	that	WDT
cord-264884-ydkigome	782	14	suggest	suggest	VBP
cord-264884-ydkigome	782	15	a	a	DT
cord-264884-ydkigome	782	16	deep	deep	JJ
cord-264884-ydkigome	782	17	evolutionary	evolutionary	JJ
cord-264884-ydkigome	782	18	relationship	relationship	NN
cord-264884-ydkigome	782	19	between	between	IN
cord-264884-ydkigome	782	20	the	the	DT
cord-264884-ydkigome	782	21	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	782	22	and	and	CC
cord-264884-ydkigome	782	23	dsDNA	dsdna	JJ
cord-264884-ydkigome	782	24	viruses	virus	NNS
cord-264884-ydkigome	782	25	of	of	IN
cord-264884-ydkigome	782	26	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	782	27	(	(	-LRB-
cord-264884-ydkigome	782	28	Rice	Rice	NNP
cord-264884-ydkigome	782	29	et	et	NNP
cord-264884-ydkigome	782	30	al	al	NNP
cord-264884-ydkigome	782	31	.	.	.
cord-264884-ydkigome	783	1	,	,	,
cord-264884-ydkigome	783	2	2004	2004	CD
cord-264884-ydkigome	783	3	;	;	:
cord-264884-ydkigome	783	4	Khayat	Khayat	NNP
cord-264884-ydkigome	783	5	et	et	NNP
cord-264884-ydkigome	783	6	al	al	NNP
cord-264884-ydkigome	783	7	.	.	NNP
cord-264884-ydkigome	783	8	,	,	,
cord-264884-ydkigome	783	9	2005	2005	CD
cord-264884-ydkigome	783	10	;	;	:
cord-264884-ydkigome	783	11	Duda	Duda	NNP
cord-264884-ydkigome	783	12	et	et	FW
cord-264884-ydkigome	783	13	al	al	NNP
cord-264884-ydkigome	783	14	.	.	NNP
cord-264884-ydkigome	783	15	,	,	,
cord-264884-ydkigome	783	16	2006	2006	CD
cord-264884-ydkigome	784	1	;	;	:
cord-264884-ydkigome	784	2	Akita	Akita	NNP
cord-264884-ydkigome	784	3	et	et	NNP
cord-264884-ydkigome	784	4	al	al	NNP
cord-264884-ydkigome	784	5	.	.	NNP
cord-264884-ydkigome	784	6	,	,	,
cord-264884-ydkigome	784	7	2007	2007	CD
cord-264884-ydkigome	784	8	)	)	-RRB-
cord-264884-ydkigome	784	9	.	.	.
cord-264884-ydkigome	785	1	Such	such	JJ
cord-264884-ydkigome	785	2	enormously	enormously	RB
cord-264884-ydkigome	785	3	distant	distant	JJ
cord-264884-ydkigome	785	4	relationships	relationship	NNS
cord-264884-ydkigome	785	5	,	,	,
cord-264884-ydkigome	785	6	however	however	RB
cord-264884-ydkigome	785	7	,	,	,
cord-264884-ydkigome	785	8	can	can	MD
cord-264884-ydkigome	785	9	not	not	RB
cord-264884-ydkigome	785	10	now	now	RB
cord-264884-ydkigome	785	11	be	be	VB
cord-264884-ydkigome	785	12	measured	measure	VBN
cord-264884-ydkigome	785	13	by	by	IN
cord-264884-ydkigome	785	14	any	any	DT
cord-264884-ydkigome	785	15	reliable	reliable	JJ
cord-264884-ydkigome	785	16	metric	metric	NN
cord-264884-ydkigome	785	17	.	.	.
cord-264884-ydkigome	786	1	Although	although	IN
cord-264884-ydkigome	786	2	herpes	herpes	NN
cord-264884-ydkigome	786	3	-	-	HYPH
cord-264884-ydkigome	786	4	like	like	JJ
cord-264884-ydkigome	786	5	viruses	virus	NNS
cord-264884-ydkigome	786	6	are	be	VBP
cord-264884-ydkigome	786	7	found	find	VBN
cord-264884-ydkigome	786	8	in	in	IN
cord-264884-ydkigome	786	9	invertebrates	invertebrate	NNS
cord-264884-ydkigome	786	10	(	(	-LRB-
cord-264884-ydkigome	786	11	such	such	JJ
cord-264884-ydkigome	786	12	as	as	IN
cord-264884-ydkigome	786	13	ostreid	ostreid	NN
cord-264884-ydkigome	786	14	herpesvirus	herpesvirus	NNP
cord-264884-ydkigome	786	15	1	1	CD
cord-264884-ydkigome	786	16	(	(	-LRB-
cord-264884-ydkigome	786	17	OsHV-1	OsHV-1	NNP
cord-264884-ydkigome	786	18	)	)	-RRB-
cord-264884-ydkigome	786	19	)	)	-RRB-
cord-264884-ydkigome	786	20	in	in	IN
cord-264884-ydkigome	786	21	both	both	CC
cord-264884-ydkigome	786	22	lytic	lytic	JJ
cord-264884-ydkigome	786	23	and	and	CC
cord-264884-ydkigome	786	24	asymptomatic	asymptomatic	JJ
cord-264884-ydkigome	786	25	states	state	NNS
cord-264884-ydkigome	786	26	(	(	-LRB-
cord-264884-ydkigome	786	27	Barbosa	Barbosa	NNP
cord-264884-ydkigome	786	28	-	-	HYPH
cord-264884-ydkigome	786	29	Solomieu	Solomieu	NNP
cord-264884-ydkigome	786	30	et	et	NNP
cord-264884-ydkigome	786	31	al	al	NNP
cord-264884-ydkigome	786	32	.	.	NNP
cord-264884-ydkigome	786	33	,	,	,
cord-264884-ydkigome	786	34	2005	2005	CD
cord-264884-ydkigome	786	35	)	)	-RRB-
cord-264884-ydkigome	786	36	,	,	,
cord-264884-ydkigome	786	37	our	-PRON-	PRP$
cord-264884-ydkigome	786	38	interest	interest	NN
cord-264884-ydkigome	786	39	in	in	IN
cord-264884-ydkigome	786	40	their	-PRON-	PRP$
cord-264884-ydkigome	786	41	evolution	evolution	NN
cord-264884-ydkigome	786	42	has	have	VBZ
cord-264884-ydkigome	786	43	been	be	VBN
cord-264884-ydkigome	786	44	mainly	mainly	RB
cord-264884-ydkigome	786	45	focussed	focusse	VBN
cord-264884-ydkigome	786	46	on	on	IN
cord-264884-ydkigome	786	47	the	the	DT
cord-264884-ydkigome	786	48	vertebrate	vertebrate	JJ
cord-264884-ydkigome	786	49	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	786	50	.	.	.
cord-264884-ydkigome	787	1	Vertebrate	vertebrate	JJ
cord-264884-ydkigome	787	2	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	787	3	do	do	VBP
cord-264884-ydkigome	787	4	tend	tend	VB
cord-264884-ydkigome	787	5	to	to	TO
cord-264884-ydkigome	787	6	show	show	VB
cord-264884-ydkigome	787	7	clear	clear	JJ
cord-264884-ydkigome	787	8	sequence	sequence	NN
cord-264884-ydkigome	787	9	conservation	conservation	NN
cord-264884-ydkigome	787	10	that	that	WDT
cord-264884-ydkigome	787	11	suggests	suggest	VBZ
cord-264884-ydkigome	787	12	broad	broad	JJ
cord-264884-ydkigome	787	13	patterns	pattern	NNS
cord-264884-ydkigome	787	14	of	of	IN
cord-264884-ydkigome	787	15	evolution	evolution	NN
cord-264884-ydkigome	787	16	.	.	.
cord-264884-ydkigome	788	1	One	one	CD
cord-264884-ydkigome	788	2	interesting	interesting	JJ
cord-264884-ydkigome	788	3	feature	feature	NN
cord-264884-ydkigome	788	4	of	of	IN
cord-264884-ydkigome	788	5	this	this	DT
cord-264884-ydkigome	788	6	evolution	evolution	NN
cord-264884-ydkigome	788	7	is	be	VBZ
cord-264884-ydkigome	788	8	the	the	DT
cord-264884-ydkigome	788	9	apparent	apparent	JJ
cord-264884-ydkigome	788	10	link	link	NN
cord-264884-ydkigome	788	11	between	between	IN
cord-264884-ydkigome	788	12	the	the	DT
cord-264884-ydkigome	788	13	biology	biology	NN
cord-264884-ydkigome	788	14	of	of	IN
cord-264884-ydkigome	788	15	the	the	DT
cord-264884-ydkigome	788	16	virus	virus	NN
cord-264884-ydkigome	788	17	and	and	CC
cord-264884-ydkigome	788	18	its	-PRON-	PRP$
cord-264884-ydkigome	788	19	evolution	evolution	NN
cord-264884-ydkigome	788	20	.	.	.
cord-264884-ydkigome	789	1	A	a	DT
cord-264884-ydkigome	789	2	common	common	JJ
cord-264884-ydkigome	789	3	,	,	,
cord-264884-ydkigome	789	4	but	but	CC
cord-264884-ydkigome	789	5	not	not	RB
cord-264884-ydkigome	789	6	universal	universal	JJ
cord-264884-ydkigome	789	7	pattern	pattern	NN
cord-264884-ydkigome	789	8	is	be	VBZ
cord-264884-ydkigome	789	9	that	that	DT
cord-264884-ydkigome	789	10	of	of	IN
cord-264884-ydkigome	789	11	virus	virus	NN
cord-264884-ydkigome	789	12	and	and	CC
cord-264884-ydkigome	789	13	host	host	NN
cord-264884-ydkigome	789	14	co	co	NN
cord-264884-ydkigome	789	15	-	-	NN
cord-264884-ydkigome	789	16	evolution	evolution	NN
cord-264884-ydkigome	790	1	(	(	-LRB-
cord-264884-ydkigome	790	2	McGeoch	McGeoch	NNP
cord-264884-ydkigome	790	3	et	et	NNP
cord-264884-ydkigome	790	4	al	al	NNP
cord-264884-ydkigome	790	5	.	.	.
cord-264884-ydkigome	791	1	,	,	,
cord-264884-ydkigome	791	2	2000	2000	CD
cord-264884-ydkigome	792	1	(	(	-LRB-
cord-264884-ydkigome	792	2	McGeoch	McGeoch	NNP
cord-264884-ydkigome	792	3	et	et	NNP
cord-264884-ydkigome	792	4	al	al	NNP
cord-264884-ydkigome	792	5	.	.	.
cord-264884-ydkigome	793	1	,	,	,
cord-264884-ydkigome	793	2	,	,	,
cord-264884-ydkigome	793	3	2006	2006	CD
cord-264884-ydkigome	793	4	McGeoch	McGeoch	NNP
cord-264884-ydkigome	793	5	and	and	CC
cord-264884-ydkigome	793	6	Gatherer	Gatherer	NNP
cord-264884-ydkigome	793	7	,	,	,
cord-264884-ydkigome	793	8	2005	2005	CD
cord-264884-ydkigome	793	9	)	)	-RRB-
cord-264884-ydkigome	793	10	.	.	.
cord-264884-ydkigome	794	1	This	this	DT
cord-264884-ydkigome	794	2	trend	trend	NN
cord-264884-ydkigome	794	3	has	have	VBZ
cord-264884-ydkigome	794	4	maintained	maintain	VBN
cord-264884-ydkigome	794	5	several	several	JJ
cord-264884-ydkigome	794	6	biological	biological	JJ
cord-264884-ydkigome	794	7	characteristics	characteristic	NNS
cord-264884-ydkigome	794	8	,	,	,
cord-264884-ydkigome	794	9	such	such	JJ
cord-264884-ydkigome	794	10	as	as	IN
cord-264884-ydkigome	794	11	highly	highly	RB
cord-264884-ydkigome	794	12	species	species	NN
cord-264884-ydkigome	794	13	host	host	NN
cord-264884-ydkigome	794	14	-	-	:
cord-264884-ydkigome	794	15	and	and	CC
cord-264884-ydkigome	794	16	tissue	tissue	NN
cord-264884-ydkigome	794	17	-	-	HYPH
cord-264884-ydkigome	794	18	specifi	specifi	VBN
cord-264884-ydkigome	795	1	c	c	LS
cord-264884-ydkigome	795	2	persistence	persistence	NN
cord-264884-ydkigome	795	3	(	(	-LRB-
cord-264884-ydkigome	795	4	i.e.	i.e.	FW
cord-264884-ydkigome	795	5	neuronal	neuronal	JJ
cord-264884-ydkigome	795	6	and	and	CC
cord-264884-ydkigome	795	7	lymphoid	lymphoid	JJ
cord-264884-ydkigome	795	8	persistence	persistence	NN
cord-264884-ydkigome	795	9	)	)	-RRB-
cord-264884-ydkigome	795	10	.	.	.
cord-264884-ydkigome	796	1	The	the	DT
cord-264884-ydkigome	796	2	discovery	discovery	NN
cord-264884-ydkigome	796	3	of	of	IN
cord-264884-ydkigome	796	4	HHV-8	HHV-8	NNP
cord-264884-ydkigome	796	5	has	have	VBZ
cord-264884-ydkigome	796	6	further	further	RB
cord-264884-ydkigome	796	7	stimulated	stimulate	VBN
cord-264884-ydkigome	796	8	studies	study	NNS
cord-264884-ydkigome	796	9	of	of	IN
cord-264884-ydkigome	796	10	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	796	11	evolution	evolution	NN
cord-264884-ydkigome	796	12	in	in	IN
cord-264884-ydkigome	796	13	that	that	DT
cord-264884-ydkigome	796	14	HHV-8	HHV-8	NNP
cord-264884-ydkigome	796	15	appears	appear	VBZ
cord-264884-ydkigome	796	16	to	to	TO
cord-264884-ydkigome	796	17	have	have	VB
cord-264884-ydkigome	796	18	undergone	undergo	VBN
cord-264884-ydkigome	796	19	much	much	JJ
cord-264884-ydkigome	796	20	recombination	recombination	NN
cord-264884-ydkigome	796	21	with	with	IN
cord-264884-ydkigome	796	22	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	796	23	of	of	IN
cord-264884-ydkigome	796	24	related	relate	VBN
cord-264884-ydkigome	796	25	primate	primate	JJ
cord-264884-ydkigome	796	26	lineages	lineage	NNS
cord-264884-ydkigome	796	27	(	(	-LRB-
cord-264884-ydkigome	796	28	McGeoch	McGeoch	NNP
cord-264884-ydkigome	796	29	and	and	CC
cord-264884-ydkigome	796	30	Davison	Davison	NNP
cord-264884-ydkigome	796	31	,	,	,
cord-264884-ydkigome	796	32	1999	1999	CD
cord-264884-ydkigome	796	33	)	)	-RRB-
cord-264884-ydkigome	796	34	.	.	.
cord-264884-ydkigome	797	1	Thus	thus	RB
cord-264884-ydkigome	797	2	recombination	recombination	NN
cord-264884-ydkigome	797	3	seems	seem	VBZ
cord-264884-ydkigome	797	4	prevalent	prevalent	JJ
cord-264884-ydkigome	797	5	in	in	IN
cord-264884-ydkigome	797	6	herpesviruses	herpesviruses	NNP
cord-264884-ydkigome	797	7	.	.	.
cord-264884-ydkigome	798	1	The	the	DT
cord-264884-ydkigome	798	2	apparent	apparent	JJ
cord-264884-ydkigome	798	3	link	link	NN
cord-264884-ydkigome	798	4	between	between	IN
cord-264884-ydkigome	798	5	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	798	6	evolution	evolution	NN
cord-264884-ydkigome	798	7	and	and	CC
cord-264884-ydkigome	798	8	recent	recent	JJ
cord-264884-ydkigome	798	9	human	human	JJ
cord-264884-ydkigome	798	10	evolution	evolution	NN
cord-264884-ydkigome	798	11	,	,	,
cord-264884-ydkigome	798	12	as	as	RB
cord-264884-ydkigome	798	13	well	well	RB
cord-264884-ydkigome	798	14	as	as	IN
cord-264884-ydkigome	798	15	an	an	DT
cord-264884-ydkigome	798	16	apparent	apparent	JJ
cord-264884-ydkigome	798	17	link	link	NN
cord-264884-ydkigome	798	18	to	to	IN
cord-264884-ydkigome	798	19	primate	primate	JJ
cord-264884-ydkigome	798	20	retroviral	retroviral	NN
cord-264884-ydkigome	798	21	evolution	evolution	NN
cord-264884-ydkigome	798	22	,	,	,
cord-264884-ydkigome	798	23	is	be	VBZ
cord-264884-ydkigome	798	24	fascinating	fascinating	JJ
cord-264884-ydkigome	798	25	,	,	,
cord-264884-ydkigome	798	26	but	but	CC
cord-264884-ydkigome	798	27	of	of	IN
cord-264884-ydkigome	798	28	unknown	unknown	JJ
cord-264884-ydkigome	798	29	signifi	signifi	NN
cord-264884-ydkigome	798	30	cance	cance	NN
cord-264884-ydkigome	798	31	(	(	-LRB-
cord-264884-ydkigome	798	32	Kung	Kung	NNP
cord-264884-ydkigome	798	33	and	and	CC
cord-264884-ydkigome	798	34	Wood	Wood	NNP
cord-264884-ydkigome	798	35	,	,	,
cord-264884-ydkigome	798	36	1994	1994	CD
cord-264884-ydkigome	798	37	;	;	:
cord-264884-ydkigome	798	38	Lacoste	Lacoste	NNP
cord-264884-ydkigome	798	39	et	et	NNP
cord-264884-ydkigome	798	40	al	al	NNP
cord-264884-ydkigome	798	41	.	.	NNP
cord-264884-ydkigome	798	42	,	,	,
cord-264884-ydkigome	798	43	2000	2000	CD
cord-264884-ydkigome	798	44	)	)	-RRB-
cord-264884-ydkigome	798	45	.	.	.
cord-264884-ydkigome	799	1	The	the	DT
cord-264884-ydkigome	799	2	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	799	3	lineages	lineage	NNS
cord-264884-ydkigome	799	4	will	will	MD
cord-264884-ydkigome	799	5	often	often	RB
cord-264884-ydkigome	799	6	show	show	VB
cord-264884-ydkigome	799	7	the	the	DT
cord-264884-ydkigome	799	8	presence	presence	NN
cord-264884-ydkigome	799	9	of	of	IN
cord-264884-ydkigome	799	10	lineage	lineage	NN
cord-264884-ydkigome	799	11	-	-	HYPH
cord-264884-ydkigome	799	12	specifi	specifi	VBN
cord-264884-ydkigome	799	13	c	c	NN
cord-264884-ydkigome	799	14	genes	gene	NNS
cord-264884-ydkigome	799	15	.	.	.
cord-264884-ydkigome	800	1	Many	many	JJ
cord-264884-ydkigome	800	2	of	of	IN
cord-264884-ydkigome	800	3	these	these	DT
cord-264884-ydkigome	800	4	genes	gene	NNS
cord-264884-ydkigome	800	5	affect	affect	VBP
cord-264884-ydkigome	800	6	innate	innate	JJ
cord-264884-ydkigome	800	7	and	and	CC
cord-264884-ydkigome	800	8	adaptive	adaptive	JJ
cord-264884-ydkigome	800	9	host	host	NN
cord-264884-ydkigome	800	10	functions	function	NNS
cord-264884-ydkigome	800	11	,	,	,
cord-264884-ydkigome	800	12	whereas	whereas	IN
cord-264884-ydkigome	800	13	others	other	NNS
cord-264884-ydkigome	800	14	affect	affect	VBP
cord-264884-ydkigome	800	15	host	host	NN
cord-264884-ydkigome	800	16	metabolism	metabolism	NN
cord-264884-ydkigome	800	17	.	.	.
cord-264884-ydkigome	801	1	When	when	WRB
cord-264884-ydkigome	801	2	the	the	DT
cord-264884-ydkigome	801	3	source	source	NN
cord-264884-ydkigome	801	4	of	of	IN
cord-264884-ydkigome	801	5	such	such	JJ
cord-264884-ydkigome	801	6	genes	gene	NNS
cord-264884-ydkigome	801	7	has	have	VBZ
cord-264884-ydkigome	801	8	been	be	VBN
cord-264884-ydkigome	801	9	contemplated	contemplate	VBN
cord-264884-ydkigome	801	10	,	,	,
cord-264884-ydkigome	801	11	in	in	IN
cord-264884-ydkigome	801	12	contrast	contrast	NN
cord-264884-ydkigome	801	13	to	to	IN
cord-264884-ydkigome	801	14	phage	phage	NN
cord-264884-ydkigome	801	15	,	,	,
cord-264884-ydkigome	801	16	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	801	17	,	,	,
cord-264884-ydkigome	801	18	or	or	CC
cord-264884-ydkigome	801	19	baculoviruses	baculoviruse	NNS
cord-264884-ydkigome	802	1	(	(	-LRB-
cord-264884-ydkigome	802	2	Herniou	Herniou	NNP
cord-264884-ydkigome	802	3	et	et	NNP
cord-264884-ydkigome	802	4	al	al	NNP
cord-264884-ydkigome	802	5	.	.	NNP
cord-264884-ydkigome	802	6	,	,	,
cord-264884-ydkigome	802	7	2001	2001	CD
cord-264884-ydkigome	802	8	)	)	-RRB-
cord-264884-ydkigome	802	9	,	,	,
cord-264884-ydkigome	802	10	it	-PRON-	PRP
cord-264884-ydkigome	802	11	is	be	VBZ
cord-264884-ydkigome	802	12	often	often	RB
cord-264884-ydkigome	802	13	proposed	propose	VBN
cord-264884-ydkigome	802	14	that	that	IN
cord-264884-ydkigome	802	15	most	most	RBS
cord-264884-ydkigome	802	16	such	such	JJ
cord-264884-ydkigome	802	17	herpes	herpes	NN
cord-264884-ydkigome	802	18	genes	gene	NNS
cord-264884-ydkigome	802	19	originate	originate	VBP
cord-264884-ydkigome	802	20	from	from	IN
cord-264884-ydkigome	802	21	the	the	DT
cord-264884-ydkigome	802	22	host	host	NN
cord-264884-ydkigome	802	23	.	.	.
cord-264884-ydkigome	803	1	It	-PRON-	PRP
cord-264884-ydkigome	803	2	is	be	VBZ
cord-264884-ydkigome	803	3	well	well	RB
cord-264884-ydkigome	803	4	accepted	accept	VBN
cord-264884-ydkigome	803	5	that	that	IN
cord-264884-ydkigome	803	6	the	the	DT
cord-264884-ydkigome	803	7	three	three	CD
cord-264884-ydkigome	803	8	major	major	JJ
cord-264884-ydkigome	803	9	lineages	lineage	NNS
cord-264884-ydkigome	803	10	of	of	IN
cord-264884-ydkigome	803	11	herpesviruses	herpesviruses	NNP
cord-264884-ydkigome	803	12	descended	descend	VBD
cord-264884-ydkigome	803	13	from	from	IN
cord-264884-ydkigome	803	14	a	a	DT
cord-264884-ydkigome	803	15	common	common	JJ
cord-264884-ydkigome	803	16	ancestor	ancestor	NN
cord-264884-ydkigome	803	17	in	in	IN
cord-264884-ydkigome	803	18	vertebrates	vertebrate	NNS
cord-264884-ydkigome	804	1	(	(	-LRB-
cord-264884-ydkigome	804	2	McGeoch	McGeoch	NNP
cord-264884-ydkigome	804	3	et	et	NNP
cord-264884-ydkigome	804	4	al	al	NNP
cord-264884-ydkigome	804	5	.	.	NNP
cord-264884-ydkigome	804	6	,	,	,
cord-264884-ydkigome	804	7	2006	2006	CD
cord-264884-ydkigome	804	8	)	)	-RRB-
cord-264884-ydkigome	804	9	.	.	.
cord-264884-ydkigome	805	1	There	there	EX
cord-264884-ydkigome	805	2	have	have	VBP
cord-264884-ydkigome	805	3	been	be	VBN
cord-264884-ydkigome	805	4	numerous	numerous	JJ
cord-264884-ydkigome	805	5	proposals	proposal	NNS
cord-264884-ydkigome	805	6	that	that	WDT
cord-264884-ydkigome	805	7	most	most	JJS
cord-264884-ydkigome	805	8	new	new	JJ
cord-264884-ydkigome	805	9	lineage	lineage	NN
cord-264884-ydkigome	805	10	-	-	HYPH
cord-264884-ydkigome	805	11	specifi	specifi	VBN
cord-264884-ydkigome	805	12	c	c	NN
cord-264884-ydkigome	805	13	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	805	14	genes	gene	NNS
cord-264884-ydkigome	805	15	have	have	VBP
cord-264884-ydkigome	805	16	originated	originate	VBN
cord-264884-ydkigome	805	17	from	from	IN
cord-264884-ydkigome	805	18	host	host	NN
cord-264884-ydkigome	805	19	(	(	-LRB-
cord-264884-ydkigome	805	20	see	see	VB
cord-264884-ydkigome	805	21	Becker	Becker	NNP
cord-264884-ydkigome	805	22	and	and	CC
cord-264884-ydkigome	805	23	Darai	Darai	NNP
cord-264884-ydkigome	805	24	,	,	,
cord-264884-ydkigome	805	25	2000	2000	CD
cord-264884-ydkigome	805	26	)	)	-RRB-
cord-264884-ydkigome	805	27	.	.	.
cord-264884-ydkigome	806	1	This	this	DT
cord-264884-ydkigome	806	2	includes	include	VBZ
cord-264884-ydkigome	806	3	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	806	4	dUTPase	dUTPase	''
cord-264884-ydkigome	806	5	(	(	-LRB-
cord-264884-ydkigome	806	6	Davison	Davison	NNP
cord-264884-ydkigome	806	7	and	and	CC
cord-264884-ydkigome	806	8	Stow	Stow	NNP
cord-264884-ydkigome	806	9	,	,	,
cord-264884-ydkigome	806	10	2005	2005	CD
cord-264884-ydkigome	806	11	)	)	-RRB-
cord-264884-ydkigome	806	12	,	,	,
cord-264884-ydkigome	806	13	and	and	CC
cord-264884-ydkigome	806	14	viral	viral	JJ
cord-264884-ydkigome	806	15	chemokines	chemokine	NNS
cord-264884-ydkigome	806	16	and	and	CC
cord-264884-ydkigome	806	17	viral	viral	JJ
cord-264884-ydkigome	806	18	Bcl-2	Bcl-2	NNP
cord-264884-ydkigome	806	19	(	(	-LRB-
cord-264884-ydkigome	806	20	Nicholas	Nicholas	NNP
cord-264884-ydkigome	806	21	et	et	NNP
cord-264884-ydkigome	806	22	al	al	NNP
cord-264884-ydkigome	806	23	.	.	NNP
cord-264884-ydkigome	806	24	,	,	,
cord-264884-ydkigome	806	25	1998	1998	CD
cord-264884-ydkigome	806	26	)	)	-RRB-
cord-264884-ydkigome	806	27	.	.	.
cord-264884-ydkigome	807	1	In	in	IN
cord-264884-ydkigome	807	2	my	-PRON-	PRP$
cord-264884-ydkigome	807	3	evaluation	evaluation	NN
cord-264884-ydkigome	807	4	of	of	IN
cord-264884-ydkigome	807	5	such	such	JJ
cord-264884-ydkigome	807	6	claims	claim	NNS
cord-264884-ydkigome	807	7	,	,	,
cord-264884-ydkigome	807	8	however	however	RB
cord-264884-ydkigome	807	9	,	,	,
cord-264884-ydkigome	807	10	it	-PRON-	PRP
cord-264884-ydkigome	807	11	seems	seem	VBZ
cord-264884-ydkigome	807	12	clear	clear	JJ
cord-264884-ydkigome	807	13	that	that	IN
cord-264884-ydkigome	807	14	the	the	DT
cord-264884-ydkigome	807	15	possibility	possibility	NN
cord-264884-ydkigome	807	16	that	that	IN
cord-264884-ydkigome	807	17	there	there	EX
cord-264884-ydkigome	807	18	was	be	VBD
cord-264884-ydkigome	807	19	an	an	DT
cord-264884-ydkigome	807	20	ancient	ancient	JJ
cord-264884-ydkigome	807	21	viral	viral	JJ
cord-264884-ydkigome	807	22	source	source	NN
cord-264884-ydkigome	807	23	of	of	IN
cord-264884-ydkigome	807	24	such	such	JJ
cord-264884-ydkigome	807	25	genes	gene	NNS
cord-264884-ydkigome	807	26	was	be	VBD
cord-264884-ydkigome	807	27	not	not	RB
cord-264884-ydkigome	807	28	considered	consider	VBN
cord-264884-ydkigome	807	29	and	and	CC
cord-264884-ydkigome	807	30	can	can	MD
cord-264884-ydkigome	807	31	not	not	RB
cord-264884-ydkigome	807	32	now	now	RB
cord-264884-ydkigome	807	33	be	be	VB
cord-264884-ydkigome	807	34	dismissed	dismiss	VBN
cord-264884-ydkigome	807	35	.	.	.
cord-264884-ydkigome	808	1	We	-PRON-	PRP
cord-264884-ydkigome	808	2	currently	currently	RB
cord-264884-ydkigome	808	3	believe	believe	VBP
cord-264884-ydkigome	808	4	that	that	IN
cord-264884-ydkigome	808	5	ancient	ancient	JJ
cord-264884-ydkigome	808	6	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	808	7	ancestors	ancestor	NNS
cord-264884-ydkigome	808	8	can	can	MD
cord-264884-ydkigome	808	9	be	be	VB
cord-264884-ydkigome	808	10	traced	trace	VBN
cord-264884-ydkigome	808	11	to	to	IN
cord-264884-ydkigome	808	12	tailed	tailed	JJ
cord-264884-ydkigome	808	13	phage	phage	NN
cord-264884-ydkigome	808	14	(	(	-LRB-
cord-264884-ydkigome	808	15	Hendrix	Hendrix	NNP
cord-264884-ydkigome	808	16	,	,	,
cord-264884-ydkigome	808	17	1999	1999	CD
cord-264884-ydkigome	808	18	;	;	:
cord-264884-ydkigome	808	19	Bamford	Bamford	NNP
cord-264884-ydkigome	808	20	,	,	,
cord-264884-ydkigome	808	21	2003	2003	CD
cord-264884-ydkigome	808	22	;	;	:
cord-264884-ydkigome	808	23	Baker	Baker	NNP
cord-264884-ydkigome	808	24	et	et	NNP
cord-264884-ydkigome	808	25	al	al	NNP
cord-264884-ydkigome	808	26	.	.	NNP
cord-264884-ydkigome	808	27	,	,	,
cord-264884-ydkigome	808	28	2005	2005	CD
cord-264884-ydkigome	808	29	;	;	:
cord-264884-ydkigome	808	30	Duda	Duda	NNP
cord-264884-ydkigome	808	31	et	et	FW
cord-264884-ydkigome	808	32	al	al	NNP
cord-264884-ydkigome	808	33	.	.	NNP
cord-264884-ydkigome	808	34	,	,	,
cord-264884-ydkigome	808	35	2006	2006	CD
cord-264884-ydkigome	808	36	;	;	:
cord-264884-ydkigome	808	37	McGeoch	McGeoch	NNP
cord-264884-ydkigome	808	38	et	et	NNP
cord-264884-ydkigome	808	39	al	al	NNP
cord-264884-ydkigome	808	40	.	.	NNP
cord-264884-ydkigome	808	41	,	,	,
cord-264884-ydkigome	808	42	2006	2006	CD
cord-264884-ydkigome	808	43	)	)	-RRB-
cord-264884-ydkigome	808	44	.	.	.
cord-264884-ydkigome	809	1	Other	other	JJ
cord-264884-ydkigome	809	2	phage	phage	NN
cord-264884-ydkigome	809	3	lineages	lineage	NNS
cord-264884-ydkigome	809	4	also	also	RB
cord-264884-ydkigome	809	5	appear	appear	VBP
cord-264884-ydkigome	809	6	to	to	TO
cord-264884-ydkigome	809	7	trace	trace	VB
cord-264884-ydkigome	809	8	to	to	IN
cord-264884-ydkigome	809	9	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	809	10	viruses	virus	NNS
cord-264884-ydkigome	809	11	(	(	-LRB-
cord-264884-ydkigome	810	1	Bamford	Bamford	NNP
cord-264884-ydkigome	810	2	et	et	NNP
cord-264884-ydkigome	810	3	al	al	NNP
cord-264884-ydkigome	810	4	.	.	NNP
cord-264884-ydkigome	810	5	,	,	,
cord-264884-ydkigome	810	6	2005b	2005b	CD
cord-264884-ydkigome	810	7	)	)	-RRB-
cord-264884-ydkigome	810	8	.	.	.
cord-264884-ydkigome	811	1	Within	within	IN
cord-264884-ydkigome	811	2	the	the	DT
cord-264884-ydkigome	811	3	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	811	4	,	,	,
cord-264884-ydkigome	811	5	the	the	DT
cord-264884-ydkigome	811	6	same	same	JJ
cord-264884-ydkigome	811	7	T-16	T-16	NNP
cord-264884-ydkigome	811	8	icosahedral	icosahedral	JJ
cord-264884-ydkigome	811	9	structure	structure	NN
cord-264884-ydkigome	811	10	,	,	,
cord-264884-ydkigome	811	11	as	as	RB
cord-264884-ydkigome	811	12	well	well	RB
cord-264884-ydkigome	811	13	as	as	IN
cord-264884-ydkigome	811	14	invertable	invertable	JJ
cord-264884-ydkigome	811	15	DNA	dna	NN
cord-264884-ydkigome	811	16	regions	region	NNS
cord-264884-ydkigome	811	17	are	be	VBP
cord-264884-ydkigome	811	18	also	also	RB
cord-264884-ydkigome	811	19	present	present	JJ
cord-264884-ydkigome	811	20	in	in	IN
cord-264884-ydkigome	811	21	the	the	DT
cord-264884-ydkigome	811	22	very	very	RB
cord-264884-ydkigome	811	23	distant	distant	JJ
cord-264884-ydkigome	811	24	but	but	CC
cord-264884-ydkigome	811	25	much	much	RB
cord-264884-ydkigome	811	26	more	more	RBR
cord-264884-ydkigome	811	27	recognizable	recognizable	JJ
cord-264884-ydkigome	811	28	oceanic	oceanic	JJ
cord-264884-ydkigome	811	29	ostreid	ostreid	NN
cord-264884-ydkigome	811	30	herpesvirus	herpesvirus	NNP
cord-264884-ydkigome	811	31	1	1	CD
cord-264884-ydkigome	811	32	.	.	.
cord-264884-ydkigome	812	1	Given	give	VBN
cord-264884-ydkigome	812	2	the	the	DT
cord-264884-ydkigome	812	3	highly	highly	RB
cord-264884-ydkigome	812	4	diverse	diverse	JJ
cord-264884-ydkigome	812	5	and	and	CC
cord-264884-ydkigome	812	6	mosaic	mosaic	JJ
cord-264884-ydkigome	812	7	nature	nature	NN
cord-264884-ydkigome	812	8	of	of	IN
cord-264884-ydkigome	812	9	large	large	JJ
cord-264884-ydkigome	812	10	DNA	dna	NN
cord-264884-ydkigome	812	11	virus	virus	NN
cord-264884-ydkigome	812	12	evolution	evolution	NN
cord-264884-ydkigome	812	13	in	in	IN
cord-264884-ydkigome	812	14	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	812	15	and	and	CC
cord-264884-ydkigome	812	16	lower	low	JJR
cord-264884-ydkigome	812	17	eukaryotes	eukaryote	NNS
cord-264884-ydkigome	812	18	described	describe	VBN
cord-264884-ydkigome	812	19	above	above	RB
cord-264884-ydkigome	812	20	,	,	,
cord-264884-ydkigome	812	21	it	-PRON-	PRP
cord-264884-ydkigome	812	22	seem	seem	VBP
cord-264884-ydkigome	812	23	quite	quite	RB
cord-264884-ydkigome	812	24	possible	possible	JJ
cord-264884-ydkigome	812	25	that	that	IN
cord-264884-ydkigome	812	26	many	many	JJ
cord-264884-ydkigome	812	27	other	other	JJ
cord-264884-ydkigome	812	28	viral	viral	JJ
cord-264884-ydkigome	812	29	genes	gene	NNS
cord-264884-ydkigome	812	30	might	may	MD
cord-264884-ydkigome	812	31	also	also	RB
cord-264884-ydkigome	812	32	trace	trace	VB
cord-264884-ydkigome	812	33	far	far	RB
cord-264884-ydkigome	812	34	back	back	RB
cord-264884-ydkigome	812	35	in	in	IN
cord-264884-ydkigome	812	36	virus	virus	NN
cord-264884-ydkigome	812	37	evolution	evolution	NN
cord-264884-ydkigome	812	38	.	.	.
cord-264884-ydkigome	813	1	Consider	consider	VB
cord-264884-ydkigome	813	2	the	the	DT
cord-264884-ydkigome	813	3	example	example	NN
cord-264884-ydkigome	813	4	of	of	IN
cord-264884-ydkigome	813	5	dUTPase	dUTPase	NNP
cord-264884-ydkigome	813	6	in	in	IN
cord-264884-ydkigome	813	7	avian	avian	JJ
cord-264884-ydkigome	813	8	and	and	CC
cord-264884-ydkigome	813	9	mammalian	mammalian	JJ
cord-264884-ydkigome	813	10	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	813	11	(	(	-LRB-
cord-264884-ydkigome	813	12	Davison	Davison	NNP
cord-264884-ydkigome	813	13	and	and	CC
cord-264884-ydkigome	813	14	Stow	Stow	NNP
cord-264884-ydkigome	813	15	,	,	,
cord-264884-ydkigome	813	16	2005	2005	CD
cord-264884-ydkigome	813	17	;	;	:
cord-264884-ydkigome	813	18	McGeehan	McGeehan	NNP
cord-264884-ydkigome	813	19	et	et	NNP
cord-264884-ydkigome	813	20	al	al	NNP
cord-264884-ydkigome	813	21	.	.	NNP
cord-264884-ydkigome	813	22	,	,	,
cord-264884-ydkigome	813	23	2001	2001	CD
cord-264884-ydkigome	813	24	)	)	-RRB-
cord-264884-ydkigome	813	25	.	.	.
cord-264884-ydkigome	814	1	The	the	DT
cord-264884-ydkigome	814	2	current	current	JJ
cord-264884-ydkigome	814	3	view	view	NN
cord-264884-ydkigome	814	4	requires	require	VBZ
cord-264884-ydkigome	814	5	very	very	RB
cord-264884-ydkigome	814	6	complicated	complicated	JJ
cord-264884-ydkigome	814	7	gene	gene	NN
cord-264884-ydkigome	814	8	rearrangements	rearrangement	NNS
cord-264884-ydkigome	814	9	to	to	TO
cord-264884-ydkigome	814	10	account	account	VB
cord-264884-ydkigome	814	11	for	for	IN
cord-264884-ydkigome	814	12	the	the	DT
cord-264884-ydkigome	814	13	viral	viral	JJ
cord-264884-ydkigome	814	14	source	source	NN
cord-264884-ydkigome	814	15	of	of	IN
cord-264884-ydkigome	814	16	this	this	DT
cord-264884-ydkigome	814	17	gene	gene	NN
cord-264884-ydkigome	814	18	from	from	IN
cord-264884-ydkigome	814	19	its	-PRON-	PRP$
cord-264884-ydkigome	814	20	host	host	NN
cord-264884-ydkigome	814	21	.	.	.
cord-264884-ydkigome	815	1	Yet	yet	CC
cord-264884-ydkigome	815	2	we	-PRON-	PRP
cord-264884-ydkigome	815	3	know	know	VBP
cord-264884-ydkigome	815	4	that	that	IN
cord-264884-ydkigome	815	5	diverse	diverse	JJ
cord-264884-ydkigome	815	6	dUTPases	dutpase	NNS
cord-264884-ydkigome	815	7	are	be	VBP
cord-264884-ydkigome	815	8	found	find	VBN
cord-264884-ydkigome	815	9	in	in	IN
cord-264884-ydkigome	815	10	many	many	JJ
cord-264884-ydkigome	815	11	ancient	ancient	JJ
cord-264884-ydkigome	815	12	viral	viral	JJ
cord-264884-ydkigome	815	13	lineages	lineage	NNS
cord-264884-ydkigome	815	14	.	.	.
cord-264884-ydkigome	816	1	For	for	IN
cord-264884-ydkigome	816	2	example	example	NN
cord-264884-ydkigome	816	3	,	,	,
cord-264884-ydkigome	816	4	the	the	DT
cord-264884-ydkigome	816	5	ERVs	erv	NNS
cord-264884-ydkigome	816	6	present	present	JJ
cord-264884-ydkigome	816	7	in	in	IN
cord-264884-ydkigome	816	8	all	all	DT
cord-264884-ydkigome	816	9	vertebrate	vertebrate	JJ
cord-264884-ydkigome	816	10	genomes	genome	NNS
cord-264884-ydkigome	816	11	also	also	RB
cord-264884-ydkigome	816	12	conserve	conserve	VBP
cord-264884-ydkigome	816	13	dUT	dut	CD
cord-264884-ydkigome	816	14	-	-	HYPH
cord-264884-ydkigome	816	15	Pase	Pase	NNP
cord-264884-ydkigome	816	16	(	(	-LRB-
cord-264884-ydkigome	816	17	Jern	Jern	NNP
cord-264884-ydkigome	816	18	et	et	FW
cord-264884-ydkigome	816	19	al	al	NNP
cord-264884-ydkigome	816	20	.	.	NNP
cord-264884-ydkigome	816	21	,	,	,
cord-264884-ydkigome	816	22	2005	2005	CD
cord-264884-ydkigome	816	23	)	)	-RRB-
cord-264884-ydkigome	816	24	,	,	,
cord-264884-ydkigome	816	25	as	as	IN
cord-264884-ydkigome	816	26	do	do	VBP
cord-264884-ydkigome	816	27	exogenous	exogenous	JJ
cord-264884-ydkigome	816	28	retroviruses	retrovirus	NNS
cord-264884-ydkigome	816	29	(	(	-LRB-
cord-264884-ydkigome	816	30	i.e.	i.e.	FW
cord-264884-ydkigome	816	31	lentiviruses	lentiviruses	NNP
cord-264884-ydkigome	816	32	)	)	-RRB-
cord-264884-ydkigome	817	1	(	(	-LRB-
cord-264884-ydkigome	817	2	McIntosh	McIntosh	NNP
cord-264884-ydkigome	817	3	and	and	CC
cord-264884-ydkigome	817	4	Haynes	Haynes	NNP
cord-264884-ydkigome	817	5	,	,	,
cord-264884-ydkigome	817	6	1996	1996	CD
cord-264884-ydkigome	817	7	)	)	-RRB-
cord-264884-ydkigome	817	8	.	.	.
cord-264884-ydkigome	818	1	In	in	IN
cord-264884-ydkigome	818	2	fact	fact	NN
cord-264884-ydkigome	818	3	,	,	,
cord-264884-ydkigome	818	4	since	since	IN
cord-264884-ydkigome	818	5	the	the	DT
cord-264884-ydkigome	818	6	herpesviruses	herpesviruses	NNP
cord-264884-ydkigome	818	7	genes	gene	NNS
cord-264884-ydkigome	818	8	are	be	VBP
cord-264884-ydkigome	818	9	especially	especially	RB
cord-264884-ydkigome	818	10	poor	poor	JJ
cord-264884-ydkigome	818	11	in	in	IN
cord-264884-ydkigome	818	12	introns	intron	NNS
cord-264884-ydkigome	818	13	,	,	,
cord-264884-ydkigome	818	14	it	-PRON-	PRP
cord-264884-ydkigome	818	15	would	would	MD
cord-264884-ydkigome	818	16	seem	seem	VB
cord-264884-ydkigome	818	17	likely	likely	JJ
cord-264884-ydkigome	818	18	that	that	IN
cord-264884-ydkigome	818	19	any	any	DT
cord-264884-ydkigome	818	20	herpesviral	herpesviral	JJ
cord-264884-ydkigome	818	21	gene	gene	NN
cord-264884-ydkigome	818	22	acquisition	acquisition	NN
cord-264884-ydkigome	818	23	would	would	MD
cord-264884-ydkigome	818	24	necessarily	necessarily	RB
cord-264884-ydkigome	818	25	involve	involve	VB
cord-264884-ydkigome	818	26	a	a	DT
cord-264884-ydkigome	818	27	retrovirus	retrovirus	NN
cord-264884-ydkigome	818	28	via	via	IN
cord-264884-ydkigome	818	29	a	a	DT
cord-264884-ydkigome	818	30	cDNA	cdna	NN
cord-264884-ydkigome	818	31	.	.	.
cord-264884-ydkigome	819	1	The	the	DT
cord-264884-ydkigome	819	2	oceans	ocean	NNS
cord-264884-ydkigome	819	3	are	be	VBP
cord-264884-ydkigome	819	4	especially	especially	RB
cord-264884-ydkigome	819	5	fi	fi	NNP
cord-264884-ydkigome	819	6	lled	lle	VBN
cord-264884-ydkigome	819	7	with	with	IN
cord-264884-ydkigome	819	8	large	large	JJ
cord-264884-ydkigome	819	9	complex	complex	JJ
cord-264884-ydkigome	819	10	DNA	dna	NN
cord-264884-ydkigome	819	11	viruses	virus	NNS
cord-264884-ydkigome	819	12	(	(	-LRB-
cord-264884-ydkigome	819	13	such	such	JJ
cord-264884-ydkigome	819	14	as	as	IN
cord-264884-ydkigome	819	15	mimivirus	mimivirus	NNP
cord-264884-ydkigome	819	16	and	and	CC
cord-264884-ydkigome	819	17	phycodnavirus	phycodnavirus	NNP
cord-264884-ydkigome	819	18	,	,	,
cord-264884-ydkigome	819	19	plus	plus	CC
cord-264884-ydkigome	819	20	numerous	numerous	JJ
cord-264884-ydkigome	819	21	relatives	relative	NNS
cord-264884-ydkigome	819	22	of	of	IN
cord-264884-ydkigome	819	23	OsHV-1	oshv-1	CD
cord-264884-ydkigome	819	24	)	)	-RRB-
cord-264884-ydkigome	819	25	thought	think	VBD
cord-264884-ydkigome	819	26	to	to	TO
cord-264884-ydkigome	819	27	be	be	VB
cord-264884-ydkigome	819	28	ancient	ancient	JJ
cord-264884-ydkigome	819	29	ancestors	ancestor	NNS
cord-264884-ydkigome	819	30	of	of	IN
cord-264884-ydkigome	819	31	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	819	32	.	.	.
cord-264884-ydkigome	820	1	The	the	DT
cord-264884-ydkigome	820	2	phycodnavirus	phycodnavirus	NNP
cord-264884-ydkigome	820	3	(	(	-LRB-
cord-264884-ydkigome	820	4	chlorella	chlorella	NN
cord-264884-ydkigome	820	5	virus	virus	NN
cord-264884-ydkigome	820	6	,	,	,
cord-264884-ydkigome	820	7	PBCV-1	PBCV-1	NNP
cord-264884-ydkigome	820	8	)	)	-RRB-
cord-264884-ydkigome	820	9	provides	provide	VBZ
cord-264884-ydkigome	820	10	a	a	DT
cord-264884-ydkigome	820	11	clear	clear	JJ
cord-264884-ydkigome	820	12	bridge	bridge	NN
cord-264884-ydkigome	820	13	between	between	IN
cord-264884-ydkigome	820	14	phage	phage	NN
cord-264884-ydkigome	820	15	and	and	CC
cord-264884-ydkigome	820	16	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	820	17	DNA	dna	NN
cord-264884-ydkigome	820	18	viruses	virus	NNS
cord-264884-ydkigome	820	19	.	.	.
cord-264884-ydkigome	821	1	PBCV-1	PBCV-1	NNP
cord-264884-ydkigome	821	2	also	also	RB
cord-264884-ydkigome	821	3	encodes	encode	VBZ
cord-264884-ydkigome	821	4	a	a	DT
cord-264884-ydkigome	821	5	dUTPase	dutpase	NN
cord-264884-ydkigome	821	6	that	that	WDT
cord-264884-ydkigome	821	7	has	have	VBZ
cord-264884-ydkigome	821	8	the	the	DT
cord-264884-ydkigome	821	9	highly	highly	RB
cord-264884-ydkigome	821	10	conserved	conserve	VBN
cord-264884-ydkigome	821	11	motif	motif	NN
cord-264884-ydkigome	821	12	III	III	NNP
cord-264884-ydkigome	822	1	(	(	-LRB-
cord-264884-ydkigome	822	2	Zhang	Zhang	NNP
cord-264884-ydkigome	822	3	et	et	NNP
cord-264884-ydkigome	822	4	al	al	NNP
cord-264884-ydkigome	822	5	.	.	NNP
cord-264884-ydkigome	822	6	,	,	,
cord-264884-ydkigome	822	7	2005	2005	CD
cord-264884-ydkigome	822	8	)	)	-RRB-
cord-264884-ydkigome	822	9	.	.	.
cord-264884-ydkigome	823	1	Many	many	JJ
cord-264884-ydkigome	823	2	phage	phage	NN
cord-264884-ydkigome	823	3	are	be	VBP
cord-264884-ydkigome	823	4	also	also	RB
cord-264884-ydkigome	823	5	known	know	VBN
cord-264884-ydkigome	823	6	to	to	TO
cord-264884-ydkigome	823	7	encode	encode	VB
cord-264884-ydkigome	823	8	dUTPases	dutpase	NNS
cord-264884-ydkigome	823	9	of	of	IN
cord-264884-ydkigome	823	10	diverse	diverse	JJ
cord-264884-ydkigome	823	11	types	type	NNS
cord-264884-ydkigome	823	12	,	,	,
cord-264884-ydkigome	823	13	such	such	JJ
cord-264884-ydkigome	823	14	as	as	IN
cord-264884-ydkigome	823	15	B.	B.	NNP
cord-264884-ydkigome	823	16	subtilis	subtili	NNS
cord-264884-ydkigome	823	17	(	(	-LRB-
cord-264884-ydkigome	823	18	SPbeta	SPbeta	NNP
cord-264884-ydkigome	823	19	)	)	-RRB-
cord-264884-ydkigome	823	20	(	(	-LRB-
cord-264884-ydkigome	823	21	Persson	Persson	NNP
cord-264884-ydkigome	823	22	et	et	NNP
cord-264884-ydkigome	823	23	al	al	NNP
cord-264884-ydkigome	823	24	.	.	NNP
cord-264884-ydkigome	823	25	,	,	,
cord-264884-ydkigome	823	26	2005	2005	CD
cord-264884-ydkigome	823	27	)	)	-RRB-
cord-264884-ydkigome	823	28	,	,	,
cord-264884-ydkigome	823	29	and	and	CC
cord-264884-ydkigome	823	30	a	a	DT
cord-264884-ydkigome	823	31	phage	phage	NN
cord-264884-ydkigome	823	32	of	of	IN
cord-264884-ydkigome	823	33	Thermus	Thermus	NNP
cord-264884-ydkigome	823	34	thermophilus	thermophilus	NNP
cord-264884-ydkigome	824	1	(	(	-LRB-
cord-264884-ydkigome	824	2	Naryshkina	Naryshkina	NNP
cord-264884-ydkigome	824	3	et	et	NNP
cord-264884-ydkigome	824	4	al	al	NNP
cord-264884-ydkigome	824	5	.	.	NNP
cord-264884-ydkigome	824	6	,	,	,
cord-264884-ydkigome	824	7	2006	2006	CD
cord-264884-ydkigome	824	8	)	)	-RRB-
cord-264884-ydkigome	824	9	.	.	.
cord-264884-ydkigome	825	1	This	this	DT
cord-264884-ydkigome	825	2	Thermus	Thermus	NNP
cord-264884-ydkigome	825	3	phage	phage	NN
cord-264884-ydkigome	825	4	(	(	-LRB-
cord-264884-ydkigome	825	5	phiYS40	phiYS40	NNP
cord-264884-ydkigome	825	6	)	)	-RRB-
cord-264884-ydkigome	825	7	is	be	VBZ
cord-264884-ydkigome	825	8	of	of	IN
cord-264884-ydkigome	825	9	special	special	JJ
cord-264884-ydkigome	825	10	note	note	NN
cord-264884-ydkigome	825	11	since	since	IN
cord-264884-ydkigome	825	12	its	-PRON-	PRP$
cord-264884-ydkigome	825	13	dUTPase	dUTPase	``
cord-264884-ydkigome	825	14	gene	gene	NN
cord-264884-ydkigome	825	15	is	be	VBZ
cord-264884-ydkigome	825	16	clearly	clearly	RB
cord-264884-ydkigome	825	17	related	relate	VBN
cord-264884-ydkigome	825	18	to	to	IN
cord-264884-ydkigome	825	19	the	the	DT
cord-264884-ydkigome	825	20	dUTPases	dutpase	NNS
cord-264884-ydkigome	825	21	of	of	IN
cord-264884-ydkigome	825	22	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	825	23	viruses	virus	NNS
cord-264884-ydkigome	825	24	and	and	CC
cord-264884-ydkigome	825	25	has	have	VBZ
cord-264884-ydkigome	825	26	a	a	DT
cord-264884-ydkigome	825	27	version	version	NN
cord-264884-ydkigome	825	28	that	that	WDT
cord-264884-ydkigome	825	29	has	have	VBZ
cord-264884-ydkigome	825	30	undergone	undergo	VBN
cord-264884-ydkigome	825	31	multiple	multiple	JJ
cord-264884-ydkigome	825	32	events	event	NNS
cord-264884-ydkigome	825	33	of	of	IN
cord-264884-ydkigome	825	34	recombination	recombination	NN
cord-264884-ydkigome	825	35	from	from	IN
cord-264884-ydkigome	825	36	apparently	apparently	RB
cord-264884-ydkigome	825	37	distinct	distinct	JJ
cord-264884-ydkigome	825	38	phage	phage	NN
cord-264884-ydkigome	825	39	,	,	,
cord-264884-ydkigome	825	40	exactly	exactly	RB
cord-264884-ydkigome	825	41	as	as	IN
cord-264884-ydkigome	825	42	expected	expect	VBN
cord-264884-ydkigome	825	43	for	for	IN
cord-264884-ydkigome	825	44	mosaic	mosaic	JJ
cord-264884-ydkigome	825	45	phage	phage	NN
cord-264884-ydkigome	825	46	genes	gene	NNS
cord-264884-ydkigome	825	47	.	.	.
cord-264884-ydkigome	826	1	Thus	thus	RB
cord-264884-ydkigome	826	2	,	,	,
cord-264884-ydkigome	826	3	the	the	DT
cord-264884-ydkigome	826	4	origin	origin	NN
cord-264884-ydkigome	826	5	of	of	IN
cord-264884-ydkigome	826	6	new	new	JJ
cord-264884-ydkigome	826	7	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	826	8	genes	gene	NNS
cord-264884-ydkigome	826	9	might	may	MD
cord-264884-ydkigome	826	10	not	not	RB
cord-264884-ydkigome	826	11	be	be	VB
cord-264884-ydkigome	826	12	so	so	RB
cord-264884-ydkigome	826	13	different	different	JJ
cord-264884-ydkigome	826	14	than	than	IN
cord-264884-ydkigome	826	15	that	that	DT
cord-264884-ydkigome	826	16	seen	see	VBN
cord-264884-ydkigome	826	17	in	in	IN
cord-264884-ydkigome	826	18	other	other	JJ
cord-264884-ydkigome	826	19	large	large	JJ
cord-264884-ydkigome	826	20	DNA	dna	NN
cord-264884-ydkigome	826	21	viruses	virus	NNS
cord-264884-ydkigome	826	22	and	and	CC
cord-264884-ydkigome	826	23	a	a	DT
cord-264884-ydkigome	826	24	potential	potential	JJ
cord-264884-ydkigome	826	25	ancient	ancient	JJ
cord-264884-ydkigome	826	26	source	source	NN
cord-264884-ydkigome	826	27	of	of	IN
cord-264884-ydkigome	826	28	new	new	JJ
cord-264884-ydkigome	826	29	genes	gene	NNS
cord-264884-ydkigome	826	30	from	from	IN
cord-264884-ydkigome	826	31	these	these	DT
cord-264884-ydkigome	826	32	ancestral	ancestral	JJ
cord-264884-ydkigome	826	33	viruses	virus	NNS
cord-264884-ydkigome	826	34	remains	remain	VBZ
cord-264884-ydkigome	826	35	plausible	plausible	JJ
cord-264884-ydkigome	826	36	.	.	.
cord-264884-ydkigome	827	1	Similar	similar	JJ
cord-264884-ydkigome	827	2	considerations	consideration	NNS
cord-264884-ydkigome	827	3	apply	apply	VBP
cord-264884-ydkigome	827	4	to	to	IN
cord-264884-ydkigome	827	5	other	other	JJ
cord-264884-ydkigome	827	6	possible	possible	JJ
cord-264884-ydkigome	827	7	examples	example	NNS
cord-264884-ydkigome	827	8	of	of	IN
cord-264884-ydkigome	827	9	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	827	10	gene	gene	NN
cord-264884-ydkigome	827	11	capture	capture	NN
cord-264884-ydkigome	827	12	.	.	.
cord-264884-ydkigome	828	1	For	for	IN
cord-264884-ydkigome	828	2	example	example	NN
cord-264884-ydkigome	828	3	,	,	,
cord-264884-ydkigome	828	4	the	the	DT
cord-264884-ydkigome	828	5	herpes	herpes	NN
cord-264884-ydkigome	828	6	thymidylate	thymidylate	NNP
cord-264884-ydkigome	828	7	synthase	synthase	NN
cord-264884-ydkigome	828	8	(	(	-LRB-
cord-264884-ydkigome	828	9	TS	TS	NNP
cord-264884-ydkigome	828	10	)	)	-RRB-
cord-264884-ydkigome	828	11	has	have	VBZ
cord-264884-ydkigome	828	12	also	also	RB
cord-264884-ydkigome	828	13	been	be	VBN
cord-264884-ydkigome	828	14	considered	consider	VBN
cord-264884-ydkigome	828	15	to	to	TO
cord-264884-ydkigome	828	16	have	have	VB
cord-264884-ydkigome	828	17	originated	originate	VBN
cord-264884-ydkigome	828	18	by	by	IN
cord-264884-ydkigome	828	19	host	host	NN
cord-264884-ydkigome	828	20	gene	gene	NN
cord-264884-ydkigome	828	21	capture	capture	NN
cord-264884-ydkigome	828	22	)	)	-RRB-
cord-264884-ydkigome	828	23	.	.	.
cord-264884-ydkigome	829	1	Yet	yet	CC
cord-264884-ydkigome	829	2	distinct	distinct	JJ
cord-264884-ydkigome	829	3	versions	version	NNS
cord-264884-ydkigome	829	4	of	of	IN
cord-264884-ydkigome	829	5	these	these	DT
cord-264884-ydkigome	829	6	genes	gene	NNS
cord-264884-ydkigome	829	7	are	be	VBP
cord-264884-ydkigome	829	8	also	also	RB
cord-264884-ydkigome	829	9	found	find	VBN
cord-264884-ydkigome	829	10	in	in	IN
cord-264884-ydkigome	829	11	different	different	JJ
cord-264884-ydkigome	829	12	herpesviral	herpesviral	JJ
cord-264884-ydkigome	829	13	lineages	lineage	NNS
cord-264884-ydkigome	829	14	,	,	,
cord-264884-ydkigome	829	15	which	which	WDT
cord-264884-ydkigome	829	16	would	would	MD
cord-264884-ydkigome	829	17	necessitate	necessitate	VB
cord-264884-ydkigome	829	18	multiple	multiple	JJ
cord-264884-ydkigome	829	19	independent	independent	JJ
cord-264884-ydkigome	829	20	"	"	``
cord-264884-ydkigome	829	21	capture	capture	NN
cord-264884-ydkigome	829	22	"	"	''
cord-264884-ydkigome	829	23	events	event	NNS
cord-264884-ydkigome	829	24	of	of	IN
cord-264884-ydkigome	829	25	different	different	JJ
cord-264884-ydkigome	829	26	version	version	NN
cord-264884-ydkigome	829	27	of	of	IN
cord-264884-ydkigome	829	28	host	host	NN
cord-264884-ydkigome	829	29	TS	TS	NNP
cord-264884-ydkigome	829	30	genes	gene	NNS
cord-264884-ydkigome	829	31	.	.	.
cord-264884-ydkigome	830	1	TS	TS	NNP
cord-264884-ydkigome	830	2	genes	gene	NNS
cord-264884-ydkigome	830	3	are	be	VBP
cord-264884-ydkigome	830	4	present	present	JJ
cord-264884-ydkigome	830	5	in	in	IN
cord-264884-ydkigome	830	6	ancient	ancient	JJ
cord-264884-ydkigome	830	7	virus	virus	NN
cord-264884-ydkigome	830	8	sources	source	NNS
cord-264884-ydkigome	830	9	.	.	.
cord-264884-ydkigome	831	1	For	for	IN
cord-264884-ydkigome	831	2	example	example	NN
cord-264884-ydkigome	831	3	,	,	,
cord-264884-ydkigome	831	4	Bacillus	bacillus	NN
cord-264884-ydkigome	831	5	phage	phage	NN
cord-264884-ydkigome	831	6	beta	beta	NN
cord-264884-ydkigome	831	7	22	22	CD
cord-264884-ydkigome	831	8	encodes	encode	VBZ
cord-264884-ydkigome	831	9	TS	TS	NNP
cord-264884-ydkigome	831	10	,	,	,
cord-264884-ydkigome	831	11	which	which	WDT
cord-264884-ydkigome	831	12	also	also	RB
cord-264884-ydkigome	831	13	has	have	VBZ
cord-264884-ydkigome	831	14	a	a	DT
cord-264884-ydkigome	831	15	self	self	NN
cord-264884-ydkigome	831	16	-	-	HYPH
cord-264884-ydkigome	831	17	splicing	splice	VBG
cord-264884-ydkigome	831	18	intron	intron	NN
cord-264884-ydkigome	831	19	(	(	-LRB-
cord-264884-ydkigome	831	20	Bechhofer	Bechhofer	NNP
cord-264884-ydkigome	831	21	et	et	NNP
cord-264884-ydkigome	831	22	al	al	NNP
cord-264884-ydkigome	831	23	.	.	NNP
cord-264884-ydkigome	831	24	,	,	,
cord-264884-ydkigome	831	25	1994	1994	CD
cord-264884-ydkigome	831	26	)	)	-RRB-
cord-264884-ydkigome	831	27	.	.	.
cord-264884-ydkigome	832	1	Also	also	RB
cord-264884-ydkigome	832	2	,	,	,
cord-264884-ydkigome	832	3	phage	phage	NNP
cord-264884-ydkigome	832	4	phiKZ	phiKZ	NNP
cord-264884-ydkigome	832	5	has	have	VBZ
cord-264884-ydkigome	832	6	a	a	DT
cord-264884-ydkigome	832	7	highly	highly	RB
cord-264884-ydkigome	832	8	conserved	conserve	VBN
cord-264884-ydkigome	832	9	TS	ts	NN
cord-264884-ydkigome	832	10	(	(	-LRB-
cord-264884-ydkigome	832	11	Mesyanzhinov	Mesyanzhinov	NNP
cord-264884-ydkigome	832	12	et	et	NNP
cord-264884-ydkigome	832	13	al	al	NNP
cord-264884-ydkigome	832	14	.	.	NNP
cord-264884-ydkigome	832	15	,	,	,
cord-264884-ydkigome	832	16	2002	2002	CD
cord-264884-ydkigome	832	17	)	)	-RRB-
cord-264884-ydkigome	832	18	,	,	,
cord-264884-ydkigome	832	19	yet	yet	CC
cord-264884-ydkigome	832	20	this	this	DT
cord-264884-ydkigome	832	21	virus	virus	NN
cord-264884-ydkigome	832	22	lacks	lack	VBZ
cord-264884-ydkigome	832	23	a	a	DT
cord-264884-ydkigome	832	24	DNA	dna	NN
cord-264884-ydkigome	832	25	polymerase	polymerase	NN
cord-264884-ydkigome	832	26	or	or	CC
cord-264884-ydkigome	832	27	other	other	JJ
cord-264884-ydkigome	832	28	replication	replication	NN
cord-264884-ydkigome	832	29	proteins	protein	NNS
cord-264884-ydkigome	832	30	,	,	,
cord-264884-ydkigome	832	31	clearly	clearly	RB
cord-264884-ydkigome	832	32	indicating	indicate	VBG
cord-264884-ydkigome	832	33	that	that	IN
cord-264884-ydkigome	832	34	the	the	DT
cord-264884-ydkigome	832	35	viral	viral	JJ
cord-264884-ydkigome	832	36	TS	TS	NNP
cord-264884-ydkigome	832	37	genes	gene	NNS
cord-264884-ydkigome	832	38	has	have	VBZ
cord-264884-ydkigome	832	39	a	a	DT
cord-264884-ydkigome	832	40	basic	basic	JJ
cord-264884-ydkigome	832	41	viral	viral	JJ
cord-264884-ydkigome	832	42	role	role	NN
cord-264884-ydkigome	832	43	.	.	.
cord-264884-ydkigome	833	1	Similarly	similarly	RB
cord-264884-ydkigome	833	2	,	,	,
cord-264884-ydkigome	833	3	the	the	DT
cord-264884-ydkigome	833	4	cytokines	cytokine	NNS
cord-264884-ydkigome	833	5	-	-	HYPH
cord-264884-ydkigome	833	6	like	like	JJ
cord-264884-ydkigome	833	7	genes	gene	NNS
cord-264884-ydkigome	833	8	(	(	-LRB-
cord-264884-ydkigome	833	9	such	such	JJ
cord-264884-ydkigome	833	10	as	as	IN
cord-264884-ydkigome	833	11	IL-10	IL-10	NNP
cord-264884-ydkigome	833	12	)	)	-RRB-
cord-264884-ydkigome	833	13	as	as	RB
cord-264884-ydkigome	833	14	found	find	VBN
cord-264884-ydkigome	833	15	in	in	IN
cord-264884-ydkigome	833	16	poxviruses	poxvirus	NNS
cord-264884-ydkigome	833	17	and	and	CC
cord-264884-ydkigome	833	18	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	833	19	appear	appear	VBP
cord-264884-ydkigome	833	20	to	to	TO
cord-264884-ydkigome	833	21	have	have	VB
cord-264884-ydkigome	833	22	originated	originate	VBN
cord-264884-ydkigome	833	23	in	in	RP
cord-264884-ydkigome	833	24	at	at	RB
cord-264884-ydkigome	833	25	least	least	RBS
cord-264884-ydkigome	833	26	three	three	CD
cord-264884-ydkigome	833	27	independent	independent	JJ
cord-264884-ydkigome	833	28	events	event	NNS
cord-264884-ydkigome	833	29	prior	prior	RB
cord-264884-ydkigome	833	30	to	to	IN
cord-264884-ydkigome	833	31	the	the	DT
cord-264884-ydkigome	833	32	divergence	divergence	NN
cord-264884-ydkigome	833	33	of	of	IN
cord-264884-ydkigome	833	34	mammalian	mammalian	JJ
cord-264884-ydkigome	833	35	eutherian	eutherian	JJ
cord-264884-ydkigome	833	36	orders	order	NNS
cord-264884-ydkigome	833	37	.	.	.
cord-264884-ydkigome	834	1	Yet	yet	CC
cord-264884-ydkigome	834	2	it	-PRON-	PRP
cord-264884-ydkigome	834	3	is	be	VBZ
cord-264884-ydkigome	834	4	still	still	RB
cord-264884-ydkigome	834	5	presupposed	presuppose	VBN
cord-264884-ydkigome	834	6	that	that	IN
cord-264884-ydkigome	834	7	they	-PRON-	PRP
cord-264884-ydkigome	834	8	are	be	VBP
cord-264884-ydkigome	834	9	necessarily	necessarily	RB
cord-264884-ydkigome	834	10	the	the	DT
cord-264884-ydkigome	834	11	products	product	NNS
cord-264884-ydkigome	834	12	of	of	IN
cord-264884-ydkigome	834	13	host	host	NN
cord-264884-ydkigome	834	14	gene	gene	NN
cord-264884-ydkigome	834	15	capture	capture	NN
cord-264884-ydkigome	834	16	(	(	-LRB-
cord-264884-ydkigome	834	17	Hughes	Hughes	NNP
cord-264884-ydkigome	834	18	,	,	,
cord-264884-ydkigome	834	19	2002	2002	CD
cord-264884-ydkigome	834	20	)	)	-RRB-
cord-264884-ydkigome	834	21	.	.	.
cord-264884-ydkigome	835	1	Comparative	comparative	JJ
cord-264884-ydkigome	835	2	genomics	genomic	NNS
cord-264884-ydkigome	835	3	supports	support	VBZ
cord-264884-ydkigome	835	4	the	the	DT
cord-264884-ydkigome	835	5	idea	idea	NN
cord-264884-ydkigome	835	6	that	that	IN
cord-264884-ydkigome	835	7	the	the	DT
cord-264884-ydkigome	835	8	herpesviruse	herpesviruse	NN
cord-264884-ydkigome	835	9	lineages	lineage	NNS
cord-264884-ydkigome	835	10	are	be	VBP
cord-264884-ydkigome	835	11	originating	originate	VBG
cord-264884-ydkigome	835	12	viral	viral	JJ
cord-264884-ydkigome	835	13	genes	gene	NNS
cord-264884-ydkigome	835	14	.	.	.
cord-264884-ydkigome	836	1	A	a	DT
cord-264884-ydkigome	836	2	broader	broad	JJR
cord-264884-ydkigome	836	3	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	836	4	analysis	analysis	NN
cord-264884-ydkigome	836	5	of	of	IN
cord-264884-ydkigome	836	6	all	all	DT
cord-264884-ydkigome	836	7	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	836	8	genomes	genome	NNS
cord-264884-ydkigome	836	9	identifi	identifi	NNP
cord-264884-ydkigome	836	10	ed	ed	NNP
cord-264884-ydkigome	836	11	only	only	RB
cord-264884-ydkigome	836	12	17	17	CD
cord-264884-ydkigome	836	13	genes	gene	NNS
cord-264884-ydkigome	836	14	in	in	IN
cord-264884-ydkigome	836	15	common	common	JJ
cord-264884-ydkigome	836	16	to	to	IN
cord-264884-ydkigome	836	17	all	all	DT
cord-264884-ydkigome	836	18	30	30	CD
cord-264884-ydkigome	836	19	taxa	taxon	NNS
cord-264884-ydkigome	836	20	of	of	IN
cord-264884-ydkigome	836	21	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	836	22	.	.	.
cord-264884-ydkigome	837	1	Thus	thus	RB
cord-264884-ydkigome	837	2	only	only	RB
cord-264884-ydkigome	837	3	30	30	CD
cord-264884-ydkigome	837	4	genes	gene	NNS
cord-264884-ydkigome	837	5	appear	appear	VBP
cord-264884-ydkigome	837	6	to	to	TO
cord-264884-ydkigome	837	7	be	be	VB
cord-264884-ydkigome	837	8	in	in	IN
cord-264884-ydkigome	837	9	common	common	JJ
cord-264884-ydkigome	837	10	to	to	IN
cord-264884-ydkigome	837	11	all	all	PDT
cord-264884-ydkigome	837	12	the	the	DT
cord-264884-ydkigome	837	13	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	837	14	.	.	.
cord-264884-ydkigome	838	1	In	in	IN
cord-264884-ydkigome	838	2	this	this	DT
cord-264884-ydkigome	838	3	analysis	analysis	NN
cord-264884-ydkigome	838	4	,	,	,
cord-264884-ydkigome	838	5	only	only	RB
cord-264884-ydkigome	838	6	a	a	DT
cord-264884-ydkigome	838	7	few	few	JJ
cord-264884-ydkigome	838	8	genes	gene	NNS
cord-264884-ydkigome	838	9	of	of	IN
cord-264884-ydkigome	838	10	recent	recent	JJ
cord-264884-ydkigome	838	11	origin	origin	NN
cord-264884-ydkigome	838	12	could	could	MD
cord-264884-ydkigome	838	13	be	be	VB
cord-264884-ydkigome	838	14	identifi	identifi	VBN
cord-264884-ydkigome	838	15	ed	ed	NNP
cord-264884-ydkigome	838	16	as	as	IN
cord-264884-ydkigome	838	17	possibly	possibly	RB
cord-264884-ydkigome	838	18	having	have	VBG
cord-264884-ydkigome	838	19	been	be	VBN
cord-264884-ydkigome	838	20	transferred	transfer	VBN
cord-264884-ydkigome	838	21	between	between	IN
cord-264884-ydkigome	838	22	virus	virus	NN
cord-264884-ydkigome	838	23	and	and	CC
cord-264884-ydkigome	838	24	host	host	NN
cord-264884-ydkigome	838	25	(	(	-LRB-
cord-264884-ydkigome	838	26	e.g.	e.g.	IN
cord-264884-ydkigome	838	27	new	new	JJ
cord-264884-ydkigome	838	28	genes	gene	NNS
cord-264884-ydkigome	838	29	found	find	VBN
cord-264884-ydkigome	838	30	at	at	IN
cord-264884-ydkigome	838	31	tips	tip	NNS
cord-264884-ydkigome	838	32	of	of	IN
cord-264884-ydkigome	838	33	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	838	34	dendograms	dendogram	NNS
cord-264884-ydkigome	838	35	)	)	-RRB-
cord-264884-ydkigome	838	36	.	.	.
cord-264884-ydkigome	839	1	Thus	thus	RB
cord-264884-ydkigome	839	2	,	,	,
cord-264884-ydkigome	839	3	gene	gene	NN
cord-264884-ydkigome	839	4	gain	gain	NN
cord-264884-ydkigome	839	5	in	in	IN
cord-264884-ydkigome	839	6	the	the	DT
cord-264884-ydkigome	839	7	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	839	8	(	(	-LRB-
cord-264884-ydkigome	839	9	as	as	IN
cord-264884-ydkigome	839	10	in	in	IN
cord-264884-ydkigome	839	11	DNA	dna	NN
cord-264884-ydkigome	839	12	phage	phage	NN
cord-264884-ydkigome	839	13	and	and	CC
cord-264884-ydkigome	839	14	phycodnavirus	phycodnavirus	NNP
cord-264884-ydkigome	839	15	)	)	-RRB-
cord-264884-ydkigome	839	16	is	be	VBZ
cord-264884-ydkigome	839	17	prevalent	prevalent	JJ
cord-264884-ydkigome	839	18	but	but	CC
cord-264884-ydkigome	839	19	the	the	DT
cord-264884-ydkigome	839	20	origination	origination	NN
cord-264884-ydkigome	839	21	of	of	IN
cord-264884-ydkigome	839	22	such	such	JJ
cord-264884-ydkigome	839	23	genes	gene	NNS
cord-264884-ydkigome	839	24	from	from	IN
cord-264884-ydkigome	839	25	the	the	DT
cord-264884-ydkigome	839	26	host	host	NN
cord-264884-ydkigome	839	27	is	be	VBZ
cord-264884-ydkigome	839	28	not	not	RB
cord-264884-ydkigome	839	29	prevalent	prevalent	JJ
cord-264884-ydkigome	839	30	.	.	.
cord-264884-ydkigome	840	1	I	-PRON-	PRP
cord-264884-ydkigome	840	2	suggest	suggest	VBP
cord-264884-ydkigome	840	3	that	that	IN
cord-264884-ydkigome	840	4	our	-PRON-	PRP$
cord-264884-ydkigome	840	5	tendency	tendency	NN
cord-264884-ydkigome	840	6	to	to	TO
cord-264884-ydkigome	840	7	assume	assume	VB
cord-264884-ydkigome	840	8	that	that	IN
cord-264884-ydkigome	840	9	new	new	JJ
cord-264884-ydkigome	840	10	viral	viral	JJ
cord-264884-ydkigome	840	11	genes	gene	NNS
cord-264884-ydkigome	840	12	are	be	VBP
cord-264884-ydkigome	840	13	usually	usually	RB
cord-264884-ydkigome	840	14	"	"	``
cord-264884-ydkigome	840	15	stolen	steal	VBN
cord-264884-ydkigome	840	16	"	"	''
cord-264884-ydkigome	840	17	from	from	IN
cord-264884-ydkigome	840	18	the	the	DT
cord-264884-ydkigome	840	19	host	host	NN
cord-264884-ydkigome	840	20	should	should	MD
cord-264884-ydkigome	840	21	be	be	VB
cord-264884-ydkigome	840	22	revised	revise	VBN
cord-264884-ydkigome	840	23	(	(	-LRB-
cord-264884-ydkigome	840	24	Moreira	Moreira	NNP
cord-264884-ydkigome	840	25	and	and	CC
cord-264884-ydkigome	840	26	Lopez	Lopez	NNP
cord-264884-ydkigome	840	27	-	-	HYPH
cord-264884-ydkigome	840	28	Garcia	Garcia	NNP
cord-264884-ydkigome	840	29	,	,	,
cord-264884-ydkigome	840	30	2005	2005	CD
cord-264884-ydkigome	840	31	)	)	-RRB-
cord-264884-ydkigome	840	32	.	.	.
cord-264884-ydkigome	841	1	In	in	IN
cord-264884-ydkigome	841	2	contrast	contrast	NN
cord-264884-ydkigome	841	3	to	to	IN
cord-264884-ydkigome	841	4	the	the	DT
cord-264884-ydkigome	841	5	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	841	6	,	,	,
cord-264884-ydkigome	841	7	the	the	DT
cord-264884-ydkigome	841	8	poxviruses	poxvirus	NNS
cord-264884-ydkigome	841	9	evolution	evolution	NN
cord-264884-ydkigome	841	10	tend	tend	VBP
cord-264884-ydkigome	841	11	to	to	TO
cord-264884-ydkigome	841	12	have	have	VB
cord-264884-ydkigome	841	13	little	little	JJ
cord-264884-ydkigome	841	14	congruence	congruence	NN
cord-264884-ydkigome	841	15	to	to	TO
cord-264884-ydkigome	841	16	host	host	VB
cord-264884-ydkigome	841	17	evolution	evolution	NN
cord-264884-ydkigome	841	18	(	(	-LRB-
cord-264884-ydkigome	841	19	see	see	VB
cord-264884-ydkigome	841	20	Chapter	chapter	NN
cord-264884-ydkigome	841	21	19	19	CD
cord-264884-ydkigome	841	22	)	)	-RRB-
cord-264884-ydkigome	841	23	.	.	.
cord-264884-ydkigome	842	1	Yet	yet	CC
cord-264884-ydkigome	842	2	,	,	,
cord-264884-ydkigome	842	3	they	-PRON-	PRP
cord-264884-ydkigome	842	4	too	too	RB
cord-264884-ydkigome	842	5	show	show	VBP
cord-264884-ydkigome	842	6	evidence	evidence	NN
cord-264884-ydkigome	842	7	of	of	IN
cord-264884-ydkigome	842	8	ancient	ancient	JJ
cord-264884-ydkigome	842	9	linkages	linkage	NNS
cord-264884-ydkigome	842	10	to	to	IN
cord-264884-ydkigome	842	11	other	other	JJ
cord-264884-ydkigome	842	12	viruses	virus	NNS
cord-264884-ydkigome	842	13	.	.	.
cord-264884-ydkigome	843	1	The	the	DT
cord-264884-ydkigome	843	2	replication	replication	NN
cord-264884-ydkigome	843	3	of	of	IN
cord-264884-ydkigome	843	4	poxvirus	poxvirus	NNP
cord-264884-ydkigome	843	5	DNA	DNA	NNP
cord-264884-ydkigome	843	6	is	be	VBZ
cord-264884-ydkigome	843	7	distinct	distinct	JJ
cord-264884-ydkigome	843	8	in	in	IN
cord-264884-ydkigome	843	9	that	that	IN
cord-264884-ydkigome	843	10	it	-PRON-	PRP
cord-264884-ydkigome	843	11	involves	involve	VBZ
cord-264884-ydkigome	843	12	a	a	DT
cord-264884-ydkigome	843	13	linear	linear	JJ
cord-264884-ydkigome	843	14	genome	genome	NN
cord-264884-ydkigome	843	15	with	with	IN
cord-264884-ydkigome	843	16	inverted	inverted	JJ
cord-264884-ydkigome	843	17	ends	end	NNS
cord-264884-ydkigome	843	18	that	that	WDT
cord-264884-ydkigome	843	19	have	have	VBP
cord-264884-ydkigome	843	20	covalently	covalently	RB
cord-264884-ydkigome	843	21	closed	close	VBN
cord-264884-ydkigome	843	22	"	"	``
cord-264884-ydkigome	843	23	snapback	snapback	NN
cord-264884-ydkigome	843	24	"	"	''
cord-264884-ydkigome	843	25	DNA	dna	NN
cord-264884-ydkigome	843	26	.	.	.
cord-264884-ydkigome	844	1	The	the	DT
cord-264884-ydkigome	844	2	resulting	result	VBG
cord-264884-ydkigome	844	3	replication	replication	NN
cord-264884-ydkigome	844	4	structures	structure	NNS
cord-264884-ydkigome	844	5	involve	involve	VBP
cord-264884-ydkigome	844	6	head	head	NN
cord-264884-ydkigome	844	7	-	-	HYPH
cord-264884-ydkigome	844	8	to	to	IN
cord-264884-ydkigome	844	9	-	-	HYPH
cord-264884-ydkigome	844	10	tail	tail	NN
cord-264884-ydkigome	844	11	and	and	CC
cord-264884-ydkigome	844	12	tail	tail	NN
cord-264884-ydkigome	844	13	-	-	HYPH
cord-264884-ydkigome	844	14	to	to	IN
cord-264884-ydkigome	844	15	-	-	HYPH
cord-264884-ydkigome	844	16	tail	tail	NN
cord-264884-ydkigome	844	17	intermediates	intermediate	NNS
cord-264884-ydkigome	844	18	.	.	.
cord-264884-ydkigome	845	1	This	this	DT
cord-264884-ydkigome	845	2	replication	replication	NN
cord-264884-ydkigome	845	3	strategy	strategy	NN
cord-264884-ydkigome	845	4	is	be	VBZ
cord-264884-ydkigome	845	5	very	very	RB
cord-264884-ydkigome	845	6	different	different	JJ
cord-264884-ydkigome	845	7	from	from	IN
cord-264884-ydkigome	845	8	that	that	DT
cord-264884-ydkigome	845	9	used	use	VBN
cord-264884-ydkigome	845	10	by	by	IN
cord-264884-ydkigome	845	11	the	the	DT
cord-264884-ydkigome	845	12	host	host	NN
cord-264884-ydkigome	845	13	(	(	-LRB-
cord-264884-ydkigome	845	14	and	and	CC
cord-264884-ydkigome	845	15	most	most	JJS
cord-264884-ydkigome	845	16	other	other	JJ
cord-264884-ydkigome	845	17	DNA	dna	NN
cord-264884-ydkigome	845	18	viruses	virus	NNS
cord-264884-ydkigome	845	19	)	)	-RRB-
cord-264884-ydkigome	845	20	,	,	,
cord-264884-ydkigome	845	21	but	but	CC
cord-264884-ydkigome	845	22	is	be	VBZ
cord-264884-ydkigome	845	23	clearly	clearly	RB
cord-264884-ydkigome	845	24	related	relate	VBN
cord-264884-ydkigome	845	25	to	to	IN
cord-264884-ydkigome	845	26	that	that	DT
cord-264884-ydkigome	845	27	found	find	VBN
cord-264884-ydkigome	845	28	in	in	IN
cord-264884-ydkigome	845	29	other	other	JJ
cord-264884-ydkigome	845	30	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	845	31	and	and	CC
cord-264884-ydkigome	845	32	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	845	33	viruses	virus	NNS
cord-264884-ydkigome	845	34	.	.	.
cord-264884-ydkigome	846	1	Similar	similar	JJ
cord-264884-ydkigome	846	2	replication	replication	NN
cord-264884-ydkigome	846	3	mechanisms	mechanism	NNS
cord-264884-ydkigome	846	4	are	be	VBP
cord-264884-ydkigome	846	5	seen	see	VBN
cord-264884-ydkigome	846	6	in	in	IN
cord-264884-ydkigome	846	7	all	all	DT
cord-264884-ydkigome	846	8	poxviruses	poxvirus	NNS
cord-264884-ydkigome	846	9	,	,	,
cord-264884-ydkigome	846	10	as	as	RB
cord-264884-ydkigome	846	11	well	well	RB
cord-264884-ydkigome	846	12	as	as	IN
cord-264884-ydkigome	846	13	African	african	JJ
cord-264884-ydkigome	846	14	swine	swine	NN
cord-264884-ydkigome	846	15	fever	fever	NN
cord-264884-ydkigome	846	16	virus	virus	NN
cord-264884-ydkigome	846	17	and	and	CC
cord-264884-ydkigome	846	18	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	846	19	(	(	-LRB-
cord-264884-ydkigome	846	20	PBCV-1	PBCV-1	NNP
cord-264884-ydkigome	846	21	)	)	-RRB-
cord-264884-ydkigome	846	22	.	.	.
cord-264884-ydkigome	847	1	This	this	DT
cord-264884-ydkigome	847	2	exact	exact	JJ
cord-264884-ydkigome	847	3	replication	replication	NN
cord-264884-ydkigome	847	4	strategy	strategy	NN
cord-264884-ydkigome	847	5	is	be	VBZ
cord-264884-ydkigome	847	6	also	also	RB
cord-264884-ydkigome	847	7	present	present	JJ
cord-264884-ydkigome	847	8	in	in	IN
cord-264884-ydkigome	847	9	archaeal	archaeal	JJ
cord-264884-ydkigome	847	10	lipothrixviruses	lipothrixviruse	NNS
cord-264884-ydkigome	847	11	(	(	-LRB-
cord-264884-ydkigome	847	12	SIRV1	SIRV1	NNP
cord-264884-ydkigome	847	13	and	and	CC
cord-264884-ydkigome	847	14	SIRV2	SIRV2	NNP
cord-264884-ydkigome	847	15	)	)	-RRB-
cord-264884-ydkigome	847	16	which	which	WDT
cord-264884-ydkigome	847	17	has	have	VBZ
cord-264884-ydkigome	847	18	been	be	VBN
cord-264884-ydkigome	847	19	proposed	propose	VBN
cord-264884-ydkigome	847	20	to	to	TO
cord-264884-ydkigome	847	21	be	be	VB
cord-264884-ydkigome	847	22	ancestral	ancestral	JJ
cord-264884-ydkigome	847	23	to	to	IN
cord-264884-ydkigome	847	24	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	847	25	and	and	CC
cord-264884-ydkigome	847	26	poxviruses	poxvirus	NNS
cord-264884-ydkigome	848	1	(	(	-LRB-
cord-264884-ydkigome	848	2	Persson	Persson	NNP
cord-264884-ydkigome	848	3	et	et	NNP
cord-264884-ydkigome	848	4	al	al	NNP
cord-264884-ydkigome	848	5	.	.	NNP
cord-264884-ydkigome	848	6	,	,	,
cord-264884-ydkigome	848	7	2005	2005	CD
cord-264884-ydkigome	848	8	)	)	-RRB-
cord-264884-ydkigome	848	9	.	.	.
cord-264884-ydkigome	849	1	A	a	DT
cord-264884-ydkigome	849	2	similar	similar	JJ
cord-264884-ydkigome	849	3	replication	replication	NN
cord-264884-ydkigome	849	4	strategy	strategy	NN
cord-264884-ydkigome	849	5	is	be	VBZ
cord-264884-ydkigome	849	6	also	also	RB
cord-264884-ydkigome	849	7	seen	see	VBN
cord-264884-ydkigome	849	8	with	with	IN
cord-264884-ydkigome	849	9	N15	N15	NNP
cord-264884-ydkigome	849	10	(	(	-LRB-
cord-264884-ydkigome	849	11	Lobocka	Lobocka	NNP
cord-264884-ydkigome	849	12	et	et	NNP
cord-264884-ydkigome	849	13	al	al	NNP
cord-264884-ydkigome	849	14	.	.	NNP
cord-264884-ydkigome	849	15	,	,	,
cord-264884-ydkigome	849	16	1996	1996	CD
cord-264884-ydkigome	849	17	)	)	-RRB-
cord-264884-ydkigome	849	18	,	,	,
cord-264884-ydkigome	849	19	an	an	DT
cord-264884-ydkigome	849	20	unusual	unusual	JJ
cord-264884-ydkigome	849	21	phage	phage	NN
cord-264884-ydkigome	849	22	of	of	IN
cord-264884-ydkigome	849	23	E.	E.	NNP
cord-264884-ydkigome	849	24	coli	coli	NNS
cord-264884-ydkigome	849	25	that	that	WDT
cord-264884-ydkigome	849	26	persists	persist	VBZ
cord-264884-ydkigome	849	27	as	as	IN
cord-264884-ydkigome	849	28	a	a	DT
cord-264884-ydkigome	849	29	linear	linear	JJ
cord-264884-ydkigome	849	30	DNA	dna	NN
cord-264884-ydkigome	849	31	(	(	-LRB-
cord-264884-ydkigome	849	32	Casjens	Casjens	NNP
cord-264884-ydkigome	849	33	et	et	NNP
cord-264884-ydkigome	849	34	al	al	NNP
cord-264884-ydkigome	849	35	.	.	NNP
cord-264884-ydkigome	849	36	,	,	,
cord-264884-ydkigome	849	37	2004	2004	CD
cord-264884-ydkigome	849	38	)	)	-RRB-
cord-264884-ydkigome	849	39	.	.	.
cord-264884-ydkigome	850	1	Conservation	conservation	NN
cord-264884-ydkigome	850	2	of	of	IN
cord-264884-ydkigome	850	3	such	such	JJ
cord-264884-ydkigome	850	4	replication	replication	NN
cord-264884-ydkigome	850	5	similarities	similarity	NNS
cord-264884-ydkigome	850	6	clearly	clearly	RB
cord-264884-ydkigome	850	7	suggests	suggest	VBZ
cord-264884-ydkigome	850	8	ancestral	ancestral	JJ
cord-264884-ydkigome	850	9	relationships	relationship	NNS
cord-264884-ydkigome	850	10	,	,	,
cord-264884-ydkigome	850	11	but	but	CC
cord-264884-ydkigome	850	12	no	no	DT
cord-264884-ydkigome	850	13	sequence	sequence	NN
cord-264884-ydkigome	850	14	similarity	similarity	NN
cord-264884-ydkigome	850	15	can	can	MD
cord-264884-ydkigome	850	16	be	be	VB
cord-264884-ydkigome	850	17	seen	see	VBN
cord-264884-ydkigome	850	18	between	between	IN
cord-264884-ydkigome	850	19	these	these	DT
cord-264884-ydkigome	850	20	viruses	virus	NNS
cord-264884-ydkigome	850	21	.	.	.
cord-264884-ydkigome	851	1	The	the	DT
cord-264884-ydkigome	851	2	similarity	similarity	NN
cord-264884-ydkigome	851	3	between	between	IN
cord-264884-ydkigome	851	4	poxvirus	poxvirus	NNP
cord-264884-ydkigome	851	5	and	and	CC
cord-264884-ydkigome	851	6	PBCV-1	PBCV-1	NNP
cord-264884-ydkigome	851	7	DNA	DNA	NNP
cord-264884-ydkigome	851	8	replication	replication	NN
cord-264884-ydkigome	851	9	deserves	deserve	VBZ
cord-264884-ydkigome	851	10	some	some	DT
cord-264884-ydkigome	851	11	additional	additional	JJ
cord-264884-ydkigome	851	12	comment	comment	NN
cord-264884-ydkigome	851	13	.	.	.
cord-264884-ydkigome	852	1	PBVC-1	PBVC-1	NNPS
cord-264884-ydkigome	852	2	and	and	CC
cord-264884-ydkigome	852	3	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	852	4	have	have	VBP
cord-264884-ydkigome	852	5	very	very	RB
cord-264884-ydkigome	852	6	similar	similar	JJ
cord-264884-ydkigome	852	7	DNA	dna	NN
cord-264884-ydkigome	852	8	polymerase	polymerase	NN
cord-264884-ydkigome	852	9	genes	gene	NNS
cord-264884-ydkigome	852	10	,	,	,
cord-264884-ydkigome	852	11	yet	yet	CC
cord-264884-ydkigome	852	12	differ	differ	VBP
cord-264884-ydkigome	852	13	fundamentally	fundamentally	RB
cord-264884-ydkigome	852	14	in	in	IN
cord-264884-ydkigome	852	15	replication	replication	NN
cord-264884-ydkigome	852	16	strategy	strategy	NN
cord-264884-ydkigome	852	17	.	.	.
cord-264884-ydkigome	853	1	Furthermore	furthermore	RB
cord-264884-ydkigome	853	2	,	,	,
cord-264884-ydkigome	853	3	the	the	DT
cord-264884-ydkigome	853	4	poxviral	poxviral	JJ
cord-264884-ydkigome	853	5	DNA	dna	NN
cord-264884-ydkigome	853	6	polymerase	polymerase	NN
cord-264884-ydkigome	853	7	gene	gene	NN
cord-264884-ydkigome	853	8	is	be	VBZ
cord-264884-ydkigome	853	9	very	very	RB
cord-264884-ydkigome	853	10	different	different	JJ
cord-264884-ydkigome	853	11	from	from	IN
cord-264884-ydkigome	853	12	that	that	DT
cord-264884-ydkigome	853	13	found	find	VBN
cord-264884-ydkigome	853	14	in	in	IN
cord-264884-ydkigome	853	15	the	the	DT
cord-264884-ydkigome	853	16	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	853	17	.	.	.
cord-264884-ydkigome	854	1	Yet	yet	RB
cord-264884-ydkigome	854	2	,	,	,
cord-264884-ydkigome	854	3	the	the	DT
cord-264884-ydkigome	854	4	PBCV-1	PBCV-1	NNP
cord-264884-ydkigome	854	5	capsid	capsid	NN
cord-264884-ydkigome	854	6	was	be	VBD
cord-264884-ydkigome	854	7	clearly	clearly	RB
cord-264884-ydkigome	854	8	similar	similar	JJ
cord-264884-ydkigome	854	9	to	to	IN
cord-264884-ydkigome	854	10	that	that	DT
cord-264884-ydkigome	854	11	of	of	IN
cord-264884-ydkigome	854	12	adenoviruses	adenovirus	NNS
cord-264884-ydkigome	854	13	and	and	CC
cord-264884-ydkigome	854	14	PRD1	PRD1	NNP
cord-264884-ydkigome	854	15	phage	phage	NN
cord-264884-ydkigome	854	16	(	(	-LRB-
cord-264884-ydkigome	854	17	and	and	CC
cord-264884-ydkigome	854	18	iridovirus	iridovirus	NNP
cord-264884-ydkigome	854	19	capsids	capsids	NNP
cord-264884-ydkigome	854	20	)	)	-RRB-
cord-264884-ydkigome	854	21	.	.	.
cord-264884-ydkigome	855	1	How	how	WRB
cord-264884-ydkigome	855	2	then	then	RB
cord-264884-ydkigome	855	3	do	do	VBP
cord-264884-ydkigome	855	4	we	-PRON-	PRP
cord-264884-ydkigome	855	5	link	link	VB
cord-264884-ydkigome	855	6	poxvirus	poxvirus	NNP
cord-264884-ydkigome	855	7	evolution	evolution	NN
cord-264884-ydkigome	855	8	to	to	IN
cord-264884-ydkigome	855	9	other	other	JJ
cord-264884-ydkigome	855	10	more	more	JJR
cord-264884-ydkigome	855	11	ancient	ancient	JJ
cord-264884-ydkigome	855	12	DNA	dna	NN
cord-264884-ydkigome	855	13	viruses	virus	NNS
cord-264884-ydkigome	855	14	,	,	,
cord-264884-ydkigome	855	15	such	such	JJ
cord-264884-ydkigome	855	16	as	as	IN
cord-264884-ydkigome	855	17	PBCV-1	PBCV-1	NNS
cord-264884-ydkigome	855	18	which	which	WDT
cord-264884-ydkigome	855	19	has	have	VBZ
cord-264884-ydkigome	855	20	the	the	DT
cord-264884-ydkigome	855	21	same	same	JJ
cord-264884-ydkigome	855	22	DNA	dna	NN
cord-264884-ydkigome	855	23	replication	replication	NN
cord-264884-ydkigome	855	24	mechanism	mechanism	NN
cord-264884-ydkigome	855	25	,	,	,
cord-264884-ydkigome	855	26	but	but	CC
cord-264884-ydkigome	855	27	distinct	distinct	JJ
cord-264884-ydkigome	855	28	replication	replication	NN
cord-264884-ydkigome	855	29	proteins	protein	NNS
cord-264884-ydkigome	855	30	?	?	.
cord-264884-ydkigome	856	1	Such	such	JJ
cord-264884-ydkigome	856	2	observations	observation	NNS
cord-264884-ydkigome	856	3	might	may	MD
cord-264884-ydkigome	856	4	seem	seem	VB
cord-264884-ydkigome	856	5	confusing	confusing	JJ
cord-264884-ydkigome	856	6	,	,	,
cord-264884-ydkigome	856	7	but	but	CC
cord-264884-ydkigome	856	8	they	-PRON-	PRP
cord-264884-ydkigome	856	9	are	be	VBP
cord-264884-ydkigome	856	10	clearly	clearly	RB
cord-264884-ydkigome	856	11	consistent	consistent	JJ
cord-264884-ydkigome	856	12	with	with	IN
cord-264884-ydkigome	856	13	mosaic	mosaic	JJ
cord-264884-ydkigome	856	14	,	,	,
cord-264884-ydkigome	856	15	reticulated	reticulated	JJ
cord-264884-ydkigome	856	16	evolution	evolution	NN
cord-264884-ydkigome	856	17	of	of	IN
cord-264884-ydkigome	856	18	DNA	dna	NN
cord-264884-ydkigome	856	19	viruses	virus	NNS
cord-264884-ydkigome	856	20	.	.	.
cord-264884-ydkigome	857	1	Various	various	JJ
cord-264884-ydkigome	857	2	distinct	distinct	JJ
cord-264884-ydkigome	857	3	phage	phage	NN
cord-264884-ydkigome	857	4	lineages	lineage	NNS
cord-264884-ydkigome	857	5	can	can	MD
cord-264884-ydkigome	857	6	link	link	VB
cord-264884-ydkigome	857	7	in	in	IN
cord-264884-ydkigome	857	8	multiple	multiple	JJ
cord-264884-ydkigome	857	9	ways	way	NNS
cord-264884-ydkigome	857	10	to	to	IN
cord-264884-ydkigome	857	11	various	various	JJ
cord-264884-ydkigome	857	12	distinct	distinct	JJ
cord-264884-ydkigome	857	13	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	857	14	DNA	dna	NN
cord-264884-ydkigome	857	15	viruses	virus	NNS
cord-264884-ydkigome	857	16	.	.	.
cord-264884-ydkigome	858	1	The	the	DT
cord-264884-ydkigome	858	2	concept	concept	NN
cord-264884-ydkigome	858	3	of	of	IN
cord-264884-ydkigome	858	4	a	a	DT
cord-264884-ydkigome	858	5	net	net	NN
cord-264884-ydkigome	858	6	or	or	CC
cord-264884-ydkigome	858	7	matrix	matrix	NN
cord-264884-ydkigome	858	8	rather	rather	RB
cord-264884-ydkigome	858	9	than	than	IN
cord-264884-ydkigome	858	10	a	a	DT
cord-264884-ydkigome	858	11	tree	tree	NN
cord-264884-ydkigome	858	12	is	be	VBZ
cord-264884-ydkigome	858	13	thus	thus	RB
cord-264884-ydkigome	858	14	a	a	DT
cord-264884-ydkigome	858	15	better	well	JJR
cord-264884-ydkigome	858	16	way	way	NN
cord-264884-ydkigome	858	17	to	to	TO
cord-264884-ydkigome	858	18	describe	describe	VB
cord-264884-ydkigome	858	19	the	the	DT
cord-264884-ydkigome	858	20	broad	broad	JJ
cord-264884-ydkigome	858	21	topology	topology	NN
cord-264884-ydkigome	858	22	of	of	IN
cord-264884-ydkigome	858	23	DNA	dna	NN
cord-264884-ydkigome	858	24	virus	virus	NN
cord-264884-ydkigome	858	25	evolution	evolution	NN
cord-264884-ydkigome	858	26	.	.	.
cord-264884-ydkigome	859	1	The	the	DT
cord-264884-ydkigome	859	2	issue	issue	NN
cord-264884-ydkigome	859	3	of	of	IN
cord-264884-ydkigome	859	4	gene	gene	NN
cord-264884-ydkigome	859	5	gain	gain	NN
cord-264884-ydkigome	859	6	and	and	CC
cord-264884-ydkigome	859	7	gene	gene	NN
cord-264884-ydkigome	859	8	loss	loss	NN
cord-264884-ydkigome	859	9	is	be	VBZ
cord-264884-ydkigome	859	10	also	also	RB
cord-264884-ydkigome	859	11	of	of	IN
cord-264884-ydkigome	859	12	central	central	JJ
cord-264884-ydkigome	859	13	interest	interest	NN
cord-264884-ydkigome	859	14	to	to	IN
cord-264884-ydkigome	859	15	orthopoxvirus	orthopoxvirus	NNP
cord-264884-ydkigome	859	16	evolution	evolution	NN
cord-264884-ydkigome	859	17	.	.	.
cord-264884-ydkigome	860	1	Typically	typically	RB
cord-264884-ydkigome	860	2	,	,	,
cord-264884-ydkigome	860	3	we	-PRON-	PRP
cord-264884-ydkigome	860	4	seek	seek	VBP
cord-264884-ydkigome	860	5	to	to	TO
cord-264884-ydkigome	860	6	understand	understand	VB
cord-264884-ydkigome	860	7	poxviruses	poxvirus	NNS
cord-264884-ydkigome	860	8	evolution	evolution	NN
cord-264884-ydkigome	860	9	from	from	IN
cord-264884-ydkigome	860	10	the	the	DT
cord-264884-ydkigome	860	11	perspective	perspective	NN
cord-264884-ydkigome	860	12	of	of	IN
cord-264884-ydkigome	860	13	pathogenesis	pathogenesis	NN
cord-264884-ydkigome	860	14	,	,	,
cord-264884-ydkigome	860	15	such	such	JJ
cord-264884-ydkigome	860	16	as	as	IN
cord-264884-ydkigome	860	17	the	the	DT
cord-264884-ydkigome	860	18	origin	origin	NN
cord-264884-ydkigome	860	19	of	of	IN
cord-264884-ydkigome	860	20	human	human	JJ
cord-264884-ydkigome	860	21	-	-	HYPH
cord-264884-ydkigome	860	22	specifi	specifi	NN
cord-264884-ydkigome	860	23	c	c	NN
cord-264884-ydkigome	860	24	smallpox	smallpox	NN
cord-264884-ydkigome	860	25	virus	virus	NN
cord-264884-ydkigome	860	26	.	.	.
cord-264884-ydkigome	861	1	With	with	IN
cord-264884-ydkigome	861	2	the	the	DT
cord-264884-ydkigome	861	3	comparative	comparative	JJ
cord-264884-ydkigome	861	4	genomics	genomic	NNS
cord-264884-ydkigome	861	5	of	of	IN
cord-264884-ydkigome	861	6	several	several	JJ
cord-264884-ydkigome	861	7	orthopoxviruses	orthopoxviruse	NNS
cord-264884-ydkigome	861	8	now	now	RB
cord-264884-ydkigome	861	9	possible	possible	JJ
cord-264884-ydkigome	861	10	,	,	,
cord-264884-ydkigome	861	11	we	-PRON-	PRP
cord-264884-ydkigome	861	12	see	see	VBP
cord-264884-ydkigome	861	13	curious	curious	JJ
cord-264884-ydkigome	861	14	overall	overall	JJ
cord-264884-ydkigome	861	15	patterns	pattern	NNS
cord-264884-ydkigome	861	16	of	of	IN
cord-264884-ydkigome	861	17	gene	gene	NN
cord-264884-ydkigome	861	18	loss	loss	NN
cord-264884-ydkigome	861	19	in	in	IN
cord-264884-ydkigome	861	20	their	-PRON-	PRP$
cord-264884-ydkigome	861	21	evolution	evolution	NN
cord-264884-ydkigome	862	1	(	(	-LRB-
cord-264884-ydkigome	862	2	Randall	Randall	NNP
cord-264884-ydkigome	862	3	et	et	NNP
cord-264884-ydkigome	862	4	al	al	NNP
cord-264884-ydkigome	862	5	.	.	NNP
cord-264884-ydkigome	862	6	,	,	,
cord-264884-ydkigome	862	7	2004	2004	CD
cord-264884-ydkigome	862	8	)	)	-RRB-
cord-264884-ydkigome	862	9	.	.	.
cord-264884-ydkigome	863	1	For	for	IN
cord-264884-ydkigome	863	2	example	example	NN
cord-264884-ydkigome	863	3	,	,	,
cord-264884-ydkigome	863	4	comparing	compare	VBG
cord-264884-ydkigome	863	5	human	human	JJ
cord-264884-ydkigome	863	6	smallpox	smallpox	NN
cord-264884-ydkigome	863	7	to	to	IN
cord-264884-ydkigome	863	8	cowpox	cowpox	NN
cord-264884-ydkigome	863	9	DNA	dna	NN
cord-264884-ydkigome	863	10	(	(	-LRB-
cord-264884-ydkigome	863	11	a	a	DT
cord-264884-ydkigome	863	12	rodent	rodent	NN
cord-264884-ydkigome	863	13	virus	virus	NN
cord-264884-ydkigome	863	14	that	that	WDT
cord-264884-ydkigome	863	15	is	be	VBZ
cord-264884-ydkigome	863	16	phylogenetically	phylogenetically	RB
cord-264884-ydkigome	863	17	basal	basal	JJ
cord-264884-ydkigome	863	18	to	to	IN
cord-264884-ydkigome	863	19	smallpox	smallpox	NN
cord-264884-ydkigome	863	20	)	)	-RRB-
cord-264884-ydkigome	863	21	,	,	,
cord-264884-ydkigome	863	22	we	-PRON-	PRP
cord-264884-ydkigome	863	23	observe	observe	VBP
cord-264884-ydkigome	863	24	an	an	DT
cord-264884-ydkigome	863	25	overall	overall	JJ
cord-264884-ydkigome	863	26	diminution	diminution	NN
cord-264884-ydkigome	863	27	of	of	IN
cord-264884-ydkigome	863	28	gene	gene	NN
cord-264884-ydkigome	863	29	content	content	NN
cord-264884-ydkigome	863	30	in	in	IN
cord-264884-ydkigome	863	31	smallpox	smallpox	NN
cord-264884-ydkigome	863	32	virus	virus	NN
cord-264884-ydkigome	863	33	.	.	.
cord-264884-ydkigome	864	1	Several	several	JJ
cord-264884-ydkigome	864	2	poxviruses	poxvirus	NNS
cord-264884-ydkigome	864	3	seem	seem	VBP
cord-264884-ydkigome	864	4	to	to	TO
cord-264884-ydkigome	864	5	have	have	VB
cord-264884-ydkigome	864	6	also	also	RB
cord-264884-ydkigome	864	7	lost	lose	VBN
cord-264884-ydkigome	864	8	genes	gene	NNS
cord-264884-ydkigome	864	9	relative	relative	JJ
cord-264884-ydkigome	864	10	to	to	IN
cord-264884-ydkigome	864	11	cowpoxvirus	cowpoxvirus	NNP
cord-264884-ydkigome	864	12	,	,	,
cord-264884-ydkigome	864	13	especially	especially	RB
cord-264884-ydkigome	864	14	genes	gene	NNS
cord-264884-ydkigome	864	15	that	that	WDT
cord-264884-ydkigome	864	16	appear	appear	VBP
cord-264884-ydkigome	864	17	to	to	TO
cord-264884-ydkigome	864	18	affect	affect	VB
cord-264884-ydkigome	864	19	immunity	immunity	NN
cord-264884-ydkigome	864	20	(	(	-LRB-
cord-264884-ydkigome	864	21	Hughes	Hughes	NNP
cord-264884-ydkigome	864	22	and	and	CC
cord-264884-ydkigome	864	23	Friedman	Friedman	NNP
cord-264884-ydkigome	864	24	,	,	,
cord-264884-ydkigome	864	25	2005	2005	CD
cord-264884-ydkigome	864	26	)	)	-RRB-
cord-264884-ydkigome	864	27	.	.	.
cord-264884-ydkigome	865	1	I	-PRON-	PRP
cord-264884-ydkigome	865	2	suggest	suggest	VBP
cord-264884-ydkigome	865	3	that	that	IN
cord-264884-ydkigome	865	4	this	this	DT
cord-264884-ydkigome	865	5	evolutionary	evolutionary	JJ
cord-264884-ydkigome	865	6	tendency	tendency	NN
cord-264884-ydkigome	865	7	for	for	IN
cord-264884-ydkigome	865	8	gene	gene	NN
cord-264884-ydkigome	865	9	reduction	reduction	NN
cord-264884-ydkigome	865	10	is	be	VBZ
cord-264884-ydkigome	865	11	associated	associate	VBN
cord-264884-ydkigome	865	12	with	with	IN
cord-264884-ydkigome	865	13	a	a	DT
cord-264884-ydkigome	865	14	switch	switch	NN
cord-264884-ydkigome	865	15	from	from	IN
cord-264884-ydkigome	865	16	a	a	DT
cord-264884-ydkigome	865	17	more	more	RBR
cord-264884-ydkigome	865	18	demanding	demanding	JJ
cord-264884-ydkigome	865	19	species	specie	NNS
cord-264884-ydkigome	865	20	-	-	HYPH
cord-264884-ydkigome	865	21	specifi	specifi	NN
cord-264884-ydkigome	865	22	c	c	NN
cord-264884-ydkigome	865	23	persistent	persistent	JJ
cord-264884-ydkigome	865	24	life	life	NN
cord-264884-ydkigome	865	25	strategy	strategy	NN
cord-264884-ydkigome	865	26	to	to	IN
cord-264884-ydkigome	865	27	a	a	DT
cord-264884-ydkigome	865	28	less	less	RBR
cord-264884-ydkigome	865	29	demanding	demanding	JJ
cord-264884-ydkigome	865	30	,	,	,
cord-264884-ydkigome	865	31	acute	acute	JJ
cord-264884-ydkigome	865	32	life	life	NN
cord-264884-ydkigome	865	33	strategy	strategy	NN
cord-264884-ydkigome	865	34	in	in	IN
cord-264884-ydkigome	865	35	a	a	DT
cord-264884-ydkigome	865	36	new	new	JJ
cord-264884-ydkigome	865	37	host	host	NN
cord-264884-ydkigome	865	38	.	.	.
cord-264884-ydkigome	866	1	Cowpox	Cowpox	NNP
cord-264884-ydkigome	866	2	is	be	VBZ
cord-264884-ydkigome	866	3	a	a	DT
cord-264884-ydkigome	866	4	naturally	naturally	RB
cord-264884-ydkigome	866	5	persistent	persistent	JJ
cord-264884-ydkigome	866	6	infection	infection	NN
cord-264884-ydkigome	866	7	in	in	IN
cord-264884-ydkigome	866	8	rodents	rodent	NNS
cord-264884-ydkigome	866	9	(	(	-LRB-
cord-264884-ydkigome	866	10	bank	bank	NN
cord-264884-ydkigome	866	11	voles	vole	NNS
cord-264884-ydkigome	866	12	)	)	-RRB-
cord-264884-ydkigome	867	1	(	(	-LRB-
cord-264884-ydkigome	867	2	Feore	Feore	NNP
cord-264884-ydkigome	867	3	et	et	NNP
cord-264884-ydkigome	867	4	al	al	NNP
cord-264884-ydkigome	867	5	.	.	NNP
cord-264884-ydkigome	867	6	,	,	,
cord-264884-ydkigome	867	7	1997	1997	CD
cord-264884-ydkigome	867	8	;	;	:
cord-264884-ydkigome	867	9	Chantrey	Chantrey	NNP
cord-264884-ydkigome	867	10	et	et	NNP
cord-264884-ydkigome	867	11	al	al	NNP
cord-264884-ydkigome	867	12	.	.	NNP
cord-264884-ydkigome	867	13	,	,	,
cord-264884-ydkigome	867	14	1999	1999	CD
cord-264884-ydkigome	867	15	)	)	-RRB-
cord-264884-ydkigome	867	16	,	,	,
cord-264884-ydkigome	867	17	which	which	WDT
cord-264884-ydkigome	867	18	has	have	VBZ
cord-264884-ydkigome	867	19	been	be	VBN
cord-264884-ydkigome	867	20	called	call	VBN
cord-264884-ydkigome	867	21	a	a	DT
cord-264884-ydkigome	867	22	natural	natural	JJ
cord-264884-ydkigome	867	23	virus	virus	NN
cord-264884-ydkigome	867	24	reservoir	reservoir	NN
cord-264884-ydkigome	867	25	(	(	-LRB-
cord-264884-ydkigome	867	26	Hazel	Hazel	NNP
cord-264884-ydkigome	867	27	et	et	NNP
cord-264884-ydkigome	867	28	al	al	NNP
cord-264884-ydkigome	867	29	.	.	NNP
cord-264884-ydkigome	867	30	,	,	,
cord-264884-ydkigome	867	31	2000	2000	CD
cord-264884-ydkigome	867	32	)	)	-RRB-
cord-264884-ydkigome	867	33	.	.	.
cord-264884-ydkigome	868	1	Smallpox	smallpox	NN
cord-264884-ydkigome	868	2	is	be	VBZ
cord-264884-ydkigome	868	3	a	a	DT
cord-264884-ydkigome	868	4	strictly	strictly	RB
cord-264884-ydkigome	868	5	acute	acute	JJ
cord-264884-ydkigome	868	6	and	and	CC
cord-264884-ydkigome	868	7	human	human	JJ
cord-264884-ydkigome	868	8	-	-	HYPH
cord-264884-ydkigome	868	9	specifi	specifi	NN
cord-264884-ydkigome	868	10	c	c	NN
cord-264884-ydkigome	868	11	disease	disease	NN
cord-264884-ydkigome	868	12	.	.	.
cord-264884-ydkigome	869	1	Such	such	JJ
cord-264884-ydkigome	869	2	gene	gene	NN
cord-264884-ydkigome	869	3	loss	loss	NN
cord-264884-ydkigome	869	4	in	in	IN
cord-264884-ydkigome	869	5	association	association	NN
cord-264884-ydkigome	869	6	with	with	IN
cord-264884-ydkigome	869	7	lost	lose	VBN
cord-264884-ydkigome	869	8	persistence	persistence	NN
cord-264884-ydkigome	869	9	could	could	MD
cord-264884-ydkigome	869	10	be	be	VB
cord-264884-ydkigome	869	11	a	a	DT
cord-264884-ydkigome	869	12	general	general	JJ
cord-264884-ydkigome	869	13	situation	situation	NN
cord-264884-ydkigome	869	14	and	and	CC
cord-264884-ydkigome	869	15	might	may	MD
cord-264884-ydkigome	869	16	also	also	RB
cord-264884-ydkigome	869	17	explain	explain	VB
cord-264884-ydkigome	869	18	why	why	WRB
cord-264884-ydkigome	869	19	clinical	clinical	JJ
cord-264884-ydkigome	869	20	isolates	isolate	NNS
cord-264884-ydkigome	869	21	of	of	IN
cord-264884-ydkigome	869	22	human	human	JJ
cord-264884-ydkigome	869	23	cytomegalovirus	cytomegalovirus	NNP
cord-264884-ydkigome	869	24	isolates	isolate	NNS
cord-264884-ydkigome	869	25	show	show	VBP
cord-264884-ydkigome	869	26	a	a	DT
cord-264884-ydkigome	869	27	strong	strong	JJ
cord-264884-ydkigome	869	28	tendency	tendency	NN
cord-264884-ydkigome	869	29	to	to	TO
cord-264884-ydkigome	869	30	delete	delete	VB
cord-264884-ydkigome	869	31	genes	gene	NNS
cord-264884-ydkigome	869	32	with	with	IN
cord-264884-ydkigome	869	33	passage	passage	NN
cord-264884-ydkigome	869	34	in	in	IN
cord-264884-ydkigome	869	35	culture	culture	NN
cord-264884-ydkigome	870	1	(	(	-LRB-
cord-264884-ydkigome	870	2	Davison	Davison	NNP
cord-264884-ydkigome	870	3	et	et	FW
cord-264884-ydkigome	870	4	al	al	NNP
cord-264884-ydkigome	870	5	.	.	NNP
cord-264884-ydkigome	870	6	,	,	,
cord-264884-ydkigome	870	7	2003	2003	CD
cord-264884-ydkigome	870	8	)	)	-RRB-
cord-264884-ydkigome	870	9	.	.	.
cord-264884-ydkigome	871	1	Most	Most	JJS
cord-264884-ydkigome	871	2	orthopoxviruses	orthopoxviruse	NNS
cord-264884-ydkigome	871	3	are	be	VBP
cord-264884-ydkigome	871	4	not	not	RB
cord-264884-ydkigome	871	5	phylogenetically	phylogenetically	RB
cord-264884-ydkigome	871	6	congruent	congruent	JJ
cord-264884-ydkigome	871	7	with	with	IN
cord-264884-ydkigome	871	8	their	-PRON-	PRP$
cord-264884-ydkigome	871	9	vertebrate	vertebrate	JJ
cord-264884-ydkigome	871	10	host	host	NN
cord-264884-ydkigome	871	11	.	.	.
cord-264884-ydkigome	872	1	Host	host	NN
cord-264884-ydkigome	872	2	switching	switch	VBG
cord-264884-ydkigome	872	3	and	and	CC
cord-264884-ydkigome	872	4	acute	acute	JJ
cord-264884-ydkigome	872	5	replication	replication	NN
cord-264884-ydkigome	872	6	seem	seem	VBP
cord-264884-ydkigome	872	7	to	to	TO
cord-264884-ydkigome	872	8	be	be	VB
cord-264884-ydkigome	872	9	relatively	relatively	RB
cord-264884-ydkigome	872	10	common	common	JJ
cord-264884-ydkigome	872	11	but	but	CC
cord-264884-ydkigome	872	12	recent	recent	JJ
cord-264884-ydkigome	872	13	occurrences	occurrence	NNS
cord-264884-ydkigome	872	14	in	in	IN
cord-264884-ydkigome	872	15	their	-PRON-	PRP$
cord-264884-ydkigome	872	16	evolution	evolution	NN
cord-264884-ydkigome	872	17	(	(	-LRB-
cord-264884-ydkigome	872	18	Babkin	Babkin	NNP
cord-264884-ydkigome	872	19	and	and	CC
cord-264884-ydkigome	872	20	Shchelkunov	Shchelkunov	NNP
cord-264884-ydkigome	872	21	,	,	,
cord-264884-ydkigome	872	22	2006	2006	CD
cord-264884-ydkigome	872	23	)	)	-RRB-
cord-264884-ydkigome	872	24	.	.	.
cord-264884-ydkigome	873	1	The	the	DT
cord-264884-ydkigome	873	2	avian	avian	JJ
cord-264884-ydkigome	873	3	poxviruses	poxvirus	NNS
cord-264884-ydkigome	873	4	are	be	VBP
cord-264884-ydkigome	873	5	not	not	RB
cord-264884-ydkigome	873	6	as	as	RB
cord-264884-ydkigome	873	7	well	well	RB
cord-264884-ydkigome	873	8	studied	study	VBN
cord-264884-ydkigome	873	9	in	in	IN
cord-264884-ydkigome	873	10	this	this	DT
cord-264884-ydkigome	873	11	context	context	NN
cord-264884-ydkigome	873	12	,	,	,
cord-264884-ydkigome	873	13	but	but	CC
cord-264884-ydkigome	873	14	curiously	curiously	RB
cord-264884-ydkigome	873	15	have	have	VBP
cord-264884-ydkigome	873	16	signifi	signifi	VBN
cord-264884-ydkigome	873	17	cantly	cantly	RB
cord-264884-ydkigome	873	18	more	more	RBR
cord-264884-ydkigome	873	19	complex	complex	JJ
cord-264884-ydkigome	873	20	genomes	genome	NNS
cord-264884-ydkigome	873	21	than	than	IN
cord-264884-ydkigome	873	22	the	the	DT
cord-264884-ydkigome	873	23	orthopoxviruses	orthopoxviruse	NNS
cord-264884-ydkigome	873	24	(	(	-LRB-
cord-264884-ydkigome	873	25	Jarmin	Jarmin	NNP
cord-264884-ydkigome	873	26	et	et	NNP
cord-264884-ydkigome	873	27	al	al	NNP
cord-264884-ydkigome	873	28	.	.	NNP
cord-264884-ydkigome	873	29	,	,	,
cord-264884-ydkigome	873	30	2006	2006	CD
cord-264884-ydkigome	873	31	)	)	-RRB-
cord-264884-ydkigome	873	32	.	.	.
cord-264884-ydkigome	874	1	The	the	DT
cord-264884-ydkigome	874	2	entomopoxviruses	entomopoxviruse	NNS
cord-264884-ydkigome	874	3	are	be	VBP
cord-264884-ydkigome	874	4	even	even	RB
cord-264884-ydkigome	874	5	less	less	RBR
cord-264884-ydkigome	874	6	well	well	RB
cord-264884-ydkigome	874	7	understood	understand	VBN
cord-264884-ydkigome	874	8	from	from	IN
cord-264884-ydkigome	874	9	both	both	CC
cord-264884-ydkigome	874	10	a	a	DT
cord-264884-ydkigome	874	11	biological	biological	JJ
cord-264884-ydkigome	874	12	and	and	CC
cord-264884-ydkigome	874	13	molecular	molecular	JJ
cord-264884-ydkigome	874	14	perspective	perspective	NN
cord-264884-ydkigome	874	15	,	,	,
cord-264884-ydkigome	874	16	although	although	IN
cord-264884-ydkigome	874	17	they	-PRON-	PRP
cord-264884-ydkigome	874	18	do	do	VBP
cord-264884-ydkigome	874	19	conserve	conserve	VB
cord-264884-ydkigome	874	20	49	49	CD
cord-264884-ydkigome	874	21	genes	gene	NNS
cord-264884-ydkigome	874	22	found	find	VBN
cord-264884-ydkigome	874	23	in	in	IN
cord-264884-ydkigome	874	24	all	all	DT
cord-264884-ydkigome	874	25	poxvirus	poxvirus	NNP
cord-264884-ydkigome	874	26	family	family	NN
cord-264884-ydkigome	874	27	members	member	NNS
cord-264884-ydkigome	874	28	(	(	-LRB-
cord-264884-ydkigome	874	29	Gubser	Gubser	NNP
cord-264884-ydkigome	874	30	et	et	FW
cord-264884-ydkigome	874	31	al	al	NNP
cord-264884-ydkigome	874	32	.	.	NNP
cord-264884-ydkigome	874	33	,	,	,
cord-264884-ydkigome	874	34	2004	2004	CD
cord-264884-ydkigome	874	35	)	)	-RRB-
cord-264884-ydkigome	874	36	.	.	.
cord-264884-ydkigome	875	1	Clearly	clearly	RB
cord-264884-ydkigome	875	2	these	these	DT
cord-264884-ydkigome	875	3	poxviruses	poxvirus	NNS
cord-264884-ydkigome	875	4	share	share	VBP
cord-264884-ydkigome	875	5	some	some	DT
cord-264884-ydkigome	875	6	degree	degree	NN
cord-264884-ydkigome	875	7	of	of	IN
cord-264884-ydkigome	875	8	evolutionary	evolutionary	JJ
cord-264884-ydkigome	875	9	history	history	NN
cord-264884-ydkigome	875	10	.	.	.
cord-264884-ydkigome	876	1	It	-PRON-	PRP
cord-264884-ydkigome	876	2	is	be	VBZ
cord-264884-ydkigome	876	3	most	most	RBS
cord-264884-ydkigome	876	4	curious	curious	JJ
cord-264884-ydkigome	876	5	that	that	IN
cord-264884-ydkigome	876	6	entomopoxviruses	entomopoxviruse	NNS
cord-264884-ydkigome	876	7	have	have	VBP
cord-264884-ydkigome	876	8	even	even	RB
cord-264884-ydkigome	876	9	larger	large	JJR
cord-264884-ydkigome	876	10	,	,	,
cord-264884-ydkigome	876	11	more	more	RBR
cord-264884-ydkigome	876	12	diverse	diverse	JJ
cord-264884-ydkigome	876	13	and	and	CC
cord-264884-ydkigome	876	14	complex	complex	JJ
cord-264884-ydkigome	876	15	genomes	genome	NNS
cord-264884-ydkigome	876	16	than	than	IN
cord-264884-ydkigome	876	17	the	the	DT
cord-264884-ydkigome	876	18	other	other	JJ
cord-264884-ydkigome	876	19	poxviruses	poxvirus	NNS
cord-264884-ydkigome	876	20	.	.	.
cord-264884-ydkigome	877	1	Why	why	WRB
cord-264884-ydkigome	877	2	?	?	.
cord-264884-ydkigome	878	1	As	as	IN
cord-264884-ydkigome	878	2	insects	insect	NNS
cord-264884-ydkigome	878	3	lack	lack	VBP
cord-264884-ydkigome	878	4	an	an	DT
cord-264884-ydkigome	878	5	adaptive	adaptive	JJ
cord-264884-ydkigome	878	6	immune	immune	JJ
cord-264884-ydkigome	878	7	system	system	NN
cord-264884-ydkigome	878	8	(	(	-LRB-
cord-264884-ydkigome	878	9	the	the	DT
cord-264884-ydkigome	878	10	target	target	NN
cord-264884-ydkigome	878	11	of	of	IN
cord-264884-ydkigome	878	12	many	many	JJ
cord-264884-ydkigome	878	13	orthopoxvirus	orthopoxvirus	JJ
cord-264884-ydkigome	878	14	genes	gene	NNS
cord-264884-ydkigome	878	15	)	)	-RRB-
cord-264884-ydkigome	878	16	,	,	,
cord-264884-ydkigome	878	17	they	-PRON-	PRP
cord-264884-ydkigome	878	18	would	would	MD
cord-264884-ydkigome	878	19	seem	seem	VB
cord-264884-ydkigome	878	20	to	to	TO
cord-264884-ydkigome	878	21	present	present	VB
cord-264884-ydkigome	878	22	a	a	DT
cord-264884-ydkigome	878	23	simpler	simple	JJR
cord-264884-ydkigome	878	24	host	host	NN
cord-264884-ydkigome	878	25	for	for	IN
cord-264884-ydkigome	878	26	virus	virus	NN
cord-264884-ydkigome	878	27	adaptation	adaptation	NN
cord-264884-ydkigome	878	28	.	.	.
cord-264884-ydkigome	879	1	This	this	DT
cord-264884-ydkigome	879	2	group	group	NN
cord-264884-ydkigome	879	3	appears	appear	VBZ
cord-264884-ydkigome	879	4	to	to	TO
cord-264884-ydkigome	879	5	be	be	VB
cord-264884-ydkigome	879	6	the	the	DT
cord-264884-ydkigome	879	7	most	most	RBS
cord-264884-ydkigome	879	8	basal	basal	JJ
cord-264884-ydkigome	879	9	phylogenetically	phylogenetically	RB
cord-264884-ydkigome	879	10	,	,	,
cord-264884-ydkigome	879	11	but	but	CC
cord-264884-ydkigome	879	12	evolutionary	evolutionary	JJ
cord-264884-ydkigome	879	13	relationships	relationship	NNS
cord-264884-ydkigome	879	14	between	between	IN
cord-264884-ydkigome	879	15	entomopoxvirus	entomopoxvirus	NNP
cord-264884-ydkigome	879	16	and	and	CC
cord-264884-ydkigome	879	17	insect	insect	NN
cord-264884-ydkigome	879	18	evolution	evolution	NN
cord-264884-ydkigome	879	19	have	have	VBP
cord-264884-ydkigome	879	20	not	not	RB
cord-264884-ydkigome	879	21	been	be	VBN
cord-264884-ydkigome	879	22	studied	study	VBN
cord-264884-ydkigome	879	23	.	.	.
cord-264884-ydkigome	880	1	The	the	DT
cord-264884-ydkigome	880	2	enotomopoxviruses	enotomopoxviruse	NNS
cord-264884-ydkigome	880	3	are	be	VBP
cord-264884-ydkigome	880	4	particularly	particularly	RB
cord-264884-ydkigome	880	5	prevalent	prevalent	JJ
cord-264884-ydkigome	880	6	in	in	IN
cord-264884-ydkigome	880	7	grasshopper	grasshopper	NN
cord-264884-ydkigome	880	8	and	and	CC
cord-264884-ydkigome	880	9	locust	locust	NN
cord-264884-ydkigome	880	10	species	specie	NNS
cord-264884-ydkigome	880	11	,	,	,
cord-264884-ydkigome	880	12	often	often	RB
cord-264884-ydkigome	880	13	in	in	IN
cord-264884-ydkigome	880	14	unapparent	unapparent	JJ
cord-264884-ydkigome	880	15	states	state	NNS
cord-264884-ydkigome	880	16	.	.	.
cord-264884-ydkigome	881	1	Interestingly	interestingly	RB
cord-264884-ydkigome	881	2	,	,	,
cord-264884-ydkigome	881	3	within	within	IN
cord-264884-ydkigome	881	4	these	these	DT
cord-264884-ydkigome	881	5	viruses	virus	NNS
cord-264884-ydkigome	881	6	we	-PRON-	PRP
cord-264884-ydkigome	881	7	can	can	MD
cord-264884-ydkigome	881	8	fi	fi	VB
cord-264884-ydkigome	881	9	nd	nd	NNP
cord-264884-ydkigome	881	10	examples	example	NNS
cord-264884-ydkigome	881	11	of	of	IN
cord-264884-ydkigome	881	12	major	major	JJ
cord-264884-ydkigome	881	13	shifts	shift	NNS
cord-264884-ydkigome	881	14	in	in	IN
cord-264884-ydkigome	881	15	core	core	NN
cord-264884-ydkigome	881	16	replication	replication	NN
cord-264884-ydkigome	881	17	genes	gene	NNS
cord-264884-ydkigome	881	18	,	,	,
cord-264884-ydkigome	881	19	such	such	JJ
cord-264884-ydkigome	881	20	as	as	IN
cord-264884-ydkigome	881	21	the	the	DT
cord-264884-ydkigome	881	22	family	family	NN
cord-264884-ydkigome	881	23	of	of	IN
cord-264884-ydkigome	881	24	DNA	dna	NN
cord-264884-ydkigome	881	25	pol	pol	NN
cord-264884-ydkigome	881	26	gene	gene	NN
cord-264884-ydkigome	881	27	that	that	WDT
cord-264884-ydkigome	881	28	is	be	VBZ
cord-264884-ydkigome	881	29	used	use	VBN
cord-264884-ydkigome	881	30	(	(	-LRB-
cord-264884-ydkigome	881	31	a	a	DT
cord-264884-ydkigome	881	32	shift	shift	NN
cord-264884-ydkigome	881	33	from	from	IN
cord-264884-ydkigome	881	34	DNA	dna	NN
cord-264884-ydkigome	881	35	pol	pol	NN
cord-264884-ydkigome	881	36	X	X	NNP
cord-264884-ydkigome	881	37	to	to	IN
cord-264884-ydkigome	881	38	DNA	dna	NN
cord-264884-ydkigome	881	39	pol	pol	NN
cord-264884-ydkigome	881	40	B	B	NNP
cord-264884-ydkigome	881	41	in	in	IN
cord-264884-ydkigome	881	42	two	two	CD
cord-264884-ydkigome	881	43	entomopoxvirus	entomopoxvirus	NNP
cord-264884-ydkigome	881	44	lineages	lineage	NNS
cord-264884-ydkigome	881	45	)	)	-RRB-
cord-264884-ydkigome	881	46	.	.	.
cord-264884-ydkigome	882	1	We	-PRON-	PRP
cord-264884-ydkigome	882	2	can	can	MD
cord-264884-ydkigome	882	3	recall	recall	VB
cord-264884-ydkigome	882	4	that	that	IN
cord-264884-ydkigome	882	5	the	the	DT
cord-264884-ydkigome	882	6	DNA	dna	NN
cord-264884-ydkigome	882	7	pol	pol	NN
cord-264884-ydkigome	882	8	B	B	NNP
cord-264884-ydkigome	882	9	gene	gene	NN
cord-264884-ydkigome	882	10	closely	closely	RB
cord-264884-ydkigome	882	11	resembles	resemble	VBZ
cord-264884-ydkigome	882	12	that	that	WDT
cord-264884-ydkigome	882	13	found	find	VBN
cord-264884-ydkigome	882	14	in	in	IN
cord-264884-ydkigome	882	15	phycodnaviruses	phycodnaviruse	NNS
cord-264884-ydkigome	882	16	(	(	-LRB-
cord-264884-ydkigome	882	17	and	and	CC
cord-264884-ydkigome	882	18	herpesvirus	herpesvirus	NNP
cord-264884-ydkigome	882	19	)	)	-RRB-
cord-264884-ydkigome	882	20	,	,	,
cord-264884-ydkigome	882	21	but	but	CC
cord-264884-ydkigome	882	22	is	be	VBZ
cord-264884-ydkigome	882	23	distinct	distinct	JJ
cord-264884-ydkigome	882	24	from	from	IN
cord-264884-ydkigome	882	25	that	that	DT
cord-264884-ydkigome	882	26	in	in	IN
cord-264884-ydkigome	882	27	orthopoxvirus	orthopoxvirus	NNP
cord-264884-ydkigome	882	28	(	(	-LRB-
cord-264884-ydkigome	882	29	Zhu	Zhu	NNP
cord-264884-ydkigome	882	30	,	,	,
cord-264884-ydkigome	882	31	2003	2003	CD
cord-264884-ydkigome	882	32	)	)	-RRB-
cord-264884-ydkigome	882	33	.	.	.
cord-264884-ydkigome	883	1	We	-PRON-	PRP
cord-264884-ydkigome	883	2	also	also	RB
cord-264884-ydkigome	883	3	see	see	VBP
cord-264884-ydkigome	883	4	in	in	IN
cord-264884-ydkigome	883	5	the	the	DT
cord-264884-ydkigome	883	6	entomopoxviruses	entomopoxviruse	NNS
cord-264884-ydkigome	883	7	some	some	DT
cord-264884-ydkigome	883	8	clear	clear	JJ
cord-264884-ydkigome	883	9	links	link	NNS
cord-264884-ydkigome	883	10	to	to	IN
cord-264884-ydkigome	883	11	phage	phage	NN
cord-264884-ydkigome	883	12	genes	gene	NNS
cord-264884-ydkigome	883	13	,	,	,
cord-264884-ydkigome	883	14	such	such	JJ
cord-264884-ydkigome	883	15	as	as	IN
cord-264884-ydkigome	883	16	T4-like	T4-like	NNP
cord-264884-ydkigome	883	17	RNA	RNA	NNP
cord-264884-ydkigome	883	18	ligase	ligase	NN
cord-264884-ydkigome	883	19	found	find	VBD
cord-264884-ydkigome	883	20	in	in	IN
cord-264884-ydkigome	883	21	all	all	DT
cord-264884-ydkigome	883	22	entomopoxviruses	entomopoxviruse	NNS
cord-264884-ydkigome	883	23	(	(	-LRB-
cord-264884-ydkigome	883	24	Ho	Ho	NNP
cord-264884-ydkigome	883	25	and	and	CC
cord-264884-ydkigome	883	26	Shuman	Shuman	NNP
cord-264884-ydkigome	883	27	,	,	,
cord-264884-ydkigome	883	28	2002	2002	CD
cord-264884-ydkigome	883	29	)	)	-RRB-
cord-264884-ydkigome	883	30	as	as	RB
cord-264884-ydkigome	883	31	well	well	RB
cord-264884-ydkigome	883	32	as	as	IN
cord-264884-ydkigome	883	33	a	a	DT
cord-264884-ydkigome	883	34	lambdalike	lambdalike	JJ
cord-264884-ydkigome	883	35	integrase	integrase	NN
cord-264884-ydkigome	883	36	seen	see	VBN
cord-264884-ydkigome	883	37	in	in	IN
cord-264884-ydkigome	883	38	D1EPV	D1EPV	NNP
cord-264884-ydkigome	883	39	(	(	-LRB-
cord-264884-ydkigome	883	40	Hashimoto	Hashimoto	NNP
cord-264884-ydkigome	883	41	and	and	CC
cord-264884-ydkigome	883	42	Lawrence	Lawrence	NNP
cord-264884-ydkigome	883	43	,	,	,
cord-264884-ydkigome	883	44	2005	2005	CD
cord-264884-ydkigome	883	45	)	)	-RRB-
cord-264884-ydkigome	883	46	.	.	.
cord-264884-ydkigome	884	1	This	this	DT
cord-264884-ydkigome	884	2	integrase	integrase	NN
cord-264884-ydkigome	884	3	in	in	IN
cord-264884-ydkigome	884	4	D1EPV	D1EPV	NNP
cord-264884-ydkigome	884	5	implies	imply	VBZ
cord-264884-ydkigome	884	6	possible	possible	JJ
cord-264884-ydkigome	884	7	integration	integration	NN
cord-264884-ydkigome	884	8	and	and	CC
cord-264884-ydkigome	884	9	persistence	persistence	NN
cord-264884-ydkigome	884	10	,	,	,
cord-264884-ydkigome	884	11	thus	thus	RB
cord-264884-ydkigome	884	12	it	-PRON-	PRP
cord-264884-ydkigome	884	13	is	be	VBZ
cord-264884-ydkigome	884	14	most	most	JJS
cord-264884-ydkigome	884	15	signifi	signifi	NNP
cord-264884-ydkigome	884	16	ca	can	MD
cord-264884-ydkigome	884	17	nt	not	RB
cord-264884-ydkigome	884	18	that	that	IN
cord-264884-ydkigome	884	19	D1EPV	D1EPV	NNP
cord-264884-ydkigome	884	20	also	also	RB
cord-264884-ydkigome	884	21	shows	show	VBZ
cord-264884-ydkigome	884	22	a	a	DT
cord-264884-ydkigome	884	23	clear	clear	JJ
cord-264884-ydkigome	884	24	persistent	persistent	JJ
cord-264884-ydkigome	884	25	host	host	NN
cord-264884-ydkigome	884	26	infection	infection	NN
cord-264884-ydkigome	884	27	as	as	RB
cord-264884-ydkigome	884	28	well	well	RB
cord-264884-ydkigome	884	29	as	as	IN
cord-264884-ydkigome	884	30	symbiosis	symbiosis	NN
cord-264884-ydkigome	884	31	and	and	CC
cord-264884-ydkigome	884	32	apparent	apparent	JJ
cord-264884-ydkigome	884	33	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	884	34	congruence	congruence	NN
cord-264884-ydkigome	884	35	between	between	IN
cord-264884-ydkigome	884	36	virus	virus	NN
cord-264884-ydkigome	884	37	and	and	CC
cord-264884-ydkigome	884	38	host	host	NN
cord-264884-ydkigome	884	39	.	.	.
cord-264884-ydkigome	885	1	This	this	DT
cord-264884-ydkigome	885	2	virus	virus	NN
cord-264884-ydkigome	885	3	is	be	VBZ
cord-264884-ydkigome	885	4	symbiotic	symbiotic	JJ
cord-264884-ydkigome	885	5	in	in	IN
cord-264884-ydkigome	885	6	its	-PRON-	PRP$
cord-264884-ydkigome	885	7	parasitoid	parasitoid	NN
cord-264884-ydkigome	885	8	wasp	wasp	NN
cord-264884-ydkigome	885	9	host	host	NN
cord-264884-ydkigome	885	10	in	in	IN
cord-264884-ydkigome	885	11	that	that	DT
cord-264884-ydkigome	885	12	virus	virus	NN
cord-264884-ydkigome	885	13	is	be	VBZ
cord-264884-ydkigome	885	14	injected	inject	VBN
cord-264884-ydkigome	885	15	into	into	IN
cord-264884-ydkigome	885	16	larval	larval	JJ
cord-264884-ydkigome	885	17	host	host	NN
cord-264884-ydkigome	885	18	along	along	IN
cord-264884-ydkigome	885	19	with	with	IN
cord-264884-ydkigome	885	20	the	the	DT
cord-264884-ydkigome	885	21	wasp	wasp	NN
cord-264884-ydkigome	885	22	egg	egg	NN
cord-264884-ydkigome	885	23	(	(	-LRB-
cord-264884-ydkigome	885	24	and	and	CC
cord-264884-ydkigome	885	25	also	also	RB
cord-264884-ydkigome	885	26	along	along	IN
cord-264884-ydkigome	885	27	with	with	IN
cord-264884-ydkigome	885	28	a	a	DT
cord-264884-ydkigome	885	29	second	second	JJ
cord-264884-ydkigome	885	30	D1RhV	D1RhV	NNP
cord-264884-ydkigome	885	31	rhabdovirus	rhabdovirus	NNP
cord-264884-ydkigome	885	32	)	)	-RRB-
cord-264884-ydkigome	885	33	and	and	CC
cord-264884-ydkigome	885	34	virus	virus	NN
cord-264884-ydkigome	885	35	is	be	VBZ
cord-264884-ydkigome	885	36	needed	need	VBN
cord-264884-ydkigome	885	37	for	for	IN
cord-264884-ydkigome	885	38	successful	successful	JJ
cord-264884-ydkigome	885	39	host	host	NN
cord-264884-ydkigome	885	40	parasitization	parasitization	NN
cord-264884-ydkigome	885	41	.	.	.
cord-264884-ydkigome	886	1	This	this	DT
cord-264884-ydkigome	886	2	symbiosis	symbiosis	NN
cord-264884-ydkigome	886	3	is	be	VBZ
cord-264884-ydkigome	886	4	clearly	clearly	RB
cord-264884-ydkigome	886	5	very	very	RB
cord-264884-ydkigome	886	6	reminiscent	reminiscent	JJ
cord-264884-ydkigome	886	7	of	of	IN
cord-264884-ydkigome	886	8	the	the	DT
cord-264884-ydkigome	886	9	genomic	genomic	JJ
cord-264884-ydkigome	886	10	polydnaviruses	polydnaviruse	NNS
cord-264884-ydkigome	886	11	of	of	IN
cord-264884-ydkigome	886	12	other	other	JJ
cord-264884-ydkigome	886	13	parasitoid	parasitoid	NN
cord-264884-ydkigome	886	14	wasp	wasp	NN
cord-264884-ydkigome	886	15	species	specie	NNS
cord-264884-ydkigome	886	16	.	.	.
cord-264884-ydkigome	887	1	DIEPV	DIEPV	NNP
cord-264884-ydkigome	887	2	is	be	VBZ
cord-264884-ydkigome	887	3	also	also	RB
cord-264884-ydkigome	887	4	expressed	express	VBN
cord-264884-ydkigome	887	5	in	in	IN
cord-264884-ydkigome	887	6	the	the	DT
cord-264884-ydkigome	887	7	male	male	JJ
cord-264884-ydkigome	887	8	poison	poison	NN
cord-264884-ydkigome	887	9	gland	gland	NN
cord-264884-ydkigome	887	10	.	.	.
cord-264884-ydkigome	888	1	However	however	RB
cord-264884-ydkigome	888	2	,	,	,
cord-264884-ydkigome	888	3	it	-PRON-	PRP
cord-264884-ydkigome	888	4	is	be	VBZ
cord-264884-ydkigome	888	5	unknown	unknown	JJ
cord-264884-ydkigome	888	6	if	if	IN
cord-264884-ydkigome	888	7	DIEPV	DIEPV	NNP
cord-264884-ydkigome	888	8	is	be	VBZ
cord-264884-ydkigome	888	9	integrating	integrate	VBG
cord-264884-ydkigome	888	10	into	into	IN
cord-264884-ydkigome	888	11	the	the	DT
cord-264884-ydkigome	888	12	host	host	NN
cord-264884-ydkigome	888	13	DNA	dna	NN
cord-264884-ydkigome	888	14	.	.	.
cord-264884-ydkigome	889	1	Clearly	clearly	RB
cord-264884-ydkigome	889	2	,	,	,
cord-264884-ydkigome	889	3	D1EPV	d1epv	VB
cord-264884-ydkigome	889	4	it	-PRON-	PRP
cord-264884-ydkigome	889	5	is	be	VBZ
cord-264884-ydkigome	889	6	part	part	NN
cord-264884-ydkigome	889	7	of	of	IN
cord-264884-ydkigome	889	8	a	a	DT
cord-264884-ydkigome	889	9	complex	complex	JJ
cord-264884-ydkigome	889	10	virus	virus	NN
cord-264884-ydkigome	889	11	-	-	HYPH
cord-264884-ydkigome	889	12	virus	virus	NN
cord-264884-ydkigome	889	13	-	-	HYPH
cord-264884-ydkigome	889	14	host	host	NN
cord-264884-ydkigome	889	15	symbiotic	symbiotic	JJ
cord-264884-ydkigome	889	16	interaction	interaction	NN
cord-264884-ydkigome	889	17	.	.	.
cord-264884-ydkigome	890	1	The	the	DT
cord-264884-ydkigome	890	2	overall	overall	JJ
cord-264884-ydkigome	890	3	evolution	evolution	NN
cord-264884-ydkigome	890	4	of	of	IN
cord-264884-ydkigome	890	5	orthopoxviruses	orthopoxviruse	NNS
cord-264884-ydkigome	890	6	contrasts	contrast	VBZ
cord-264884-ydkigome	890	7	sharply	sharply	RB
cord-264884-ydkigome	890	8	with	with	IN
cord-264884-ydkigome	890	9	that	that	DT
cord-264884-ydkigome	890	10	of	of	IN
cord-264884-ydkigome	890	11	the	the	DT
cord-264884-ydkigome	890	12	papillomaviruses	papillomaviruse	NNS
cord-264884-ydkigome	890	13	as	as	IN
cord-264884-ydkigome	890	14	presented	present	VBN
cord-264884-ydkigome	890	15	by	by	IN
cord-264884-ydkigome	890	16	Bernard	Bernard	NNP
cord-264884-ydkigome	890	17	in	in	IN
cord-264884-ydkigome	890	18	Chapter	Chapter	NNP
cord-264884-ydkigome	890	19	18	18	CD
cord-264884-ydkigome	890	20	.	.	.
cord-264884-ydkigome	891	1	Here	here	RB
cord-264884-ydkigome	891	2	,	,	,
cord-264884-ydkigome	891	3	highly	highly	RB
cord-264884-ydkigome	891	4	species	species	NN
cord-264884-ydkigome	891	5	-	-	HYPH
cord-264884-ydkigome	891	6	specifi	specifi	NN
cord-264884-ydkigome	891	7	c	c	NN
cord-264884-ydkigome	891	8	and	and	CC
cord-264884-ydkigome	891	9	tissuespecifi	tissuespecifi	NNP
cord-264884-ydkigome	891	10	c	c	NNP
cord-264884-ydkigome	891	11	host	host	NN
cord-264884-ydkigome	891	12	infection	infection	NN
cord-264884-ydkigome	891	13	are	be	VBP
cord-264884-ydkigome	891	14	the	the	DT
cord-264884-ydkigome	891	15	norm	norm	NN
cord-264884-ydkigome	891	16	and	and	CC
cord-264884-ydkigome	891	17	the	the	DT
cord-264884-ydkigome	891	18	viral	viral	JJ
cord-264884-ydkigome	891	19	evolution	evolution	NN
cord-264884-ydkigome	891	20	is	be	VBZ
cord-264884-ydkigome	891	21	typically	typically	RB
cord-264884-ydkigome	891	22	highly	highly	RB
cord-264884-ydkigome	891	23	congruent	congruent	JJ
cord-264884-ydkigome	891	24	with	with	IN
cord-264884-ydkigome	891	25	the	the	DT
cord-264884-ydkigome	891	26	host	host	NN
cord-264884-ydkigome	891	27	(	(	-LRB-
cord-264884-ydkigome	891	28	with	with	IN
cord-264884-ydkigome	891	29	some	some	DT
cord-264884-ydkigome	891	30	exceptions	exception	NNS
cord-264884-ydkigome	891	31	)	)	-RRB-
cord-264884-ydkigome	891	32	.	.	.
cord-264884-ydkigome	892	1	The	the	DT
cord-264884-ydkigome	892	2	resolution	resolution	NN
cord-264884-ydkigome	892	3	between	between	IN
cord-264884-ydkigome	892	4	virus	virus	NN
cord-264884-ydkigome	892	5	and	and	CC
cord-264884-ydkigome	892	6	host	host	NN
cord-264884-ydkigome	892	7	can	can	MD
cord-264884-ydkigome	892	8	be	be	VB
cord-264884-ydkigome	892	9	high	high	JJ
cord-264884-ydkigome	892	10	,	,	,
cord-264884-ydkigome	892	11	in	in	IN
cord-264884-ydkigome	892	12	that	that	DT
cord-264884-ydkigome	892	13	human	human	JJ
cord-264884-ydkigome	892	14	racial	racial	JJ
cord-264884-ydkigome	892	15	and	and	CC
cord-264884-ydkigome	892	16	geographical	geographical	JJ
cord-264884-ydkigome	892	17	populations	population	NNS
cord-264884-ydkigome	892	18	,	,	,
cord-264884-ydkigome	892	19	for	for	IN
cord-264884-ydkigome	892	20	example	example	NN
cord-264884-ydkigome	892	21	,	,	,
cord-264884-ydkigome	892	22	can	can	MD
cord-264884-ydkigome	892	23	often	often	RB
cord-264884-ydkigome	892	24	be	be	VB
cord-264884-ydkigome	892	25	differentiated	differentiate	VBN
cord-264884-ydkigome	892	26	based	base	VBN
cord-264884-ydkigome	892	27	on	on	IN
cord-264884-ydkigome	892	28	the	the	DT
cord-264884-ydkigome	892	29	type	type	NN
cord-264884-ydkigome	892	30	of	of	IN
cord-264884-ydkigome	892	31	HPV	hpv	NN
cord-264884-ydkigome	892	32	they	-PRON-	PRP
cord-264884-ydkigome	892	33	harbor	harbor	VBP
cord-264884-ydkigome	892	34	.	.	.
cord-264884-ydkigome	893	1	Yet	yet	CC
cord-264884-ydkigome	893	2	here	here	RB
cord-264884-ydkigome	893	3	too	too	RB
cord-264884-ydkigome	893	4	there	there	EX
cord-264884-ydkigome	893	5	is	be	VBZ
cord-264884-ydkigome	893	6	evidence	evidence	NN
cord-264884-ydkigome	893	7	of	of	IN
cord-264884-ydkigome	893	8	signifi	signifi	NNP
cord-264884-ydkigome	893	9	ca	can	MD
cord-264884-ydkigome	893	10	nt	not	RB
cord-264884-ydkigome	893	11	shifts	shift	NNS
cord-264884-ydkigome	893	12	in	in	IN
cord-264884-ydkigome	893	13	core	core	NN
cord-264884-ydkigome	893	14	gene	gene	NN
cord-264884-ydkigome	893	15	usage	usage	NN
cord-264884-ydkigome	893	16	early	early	RB
cord-264884-ydkigome	893	17	during	during	IN
cord-264884-ydkigome	893	18	papillomavirus	papillomavirus	NN
cord-264884-ydkigome	893	19	evolution	evolution	NN
cord-264884-ydkigome	893	20	.	.	.
cord-264884-ydkigome	894	1	In	in	IN
cord-264884-ydkigome	894	2	the	the	DT
cord-264884-ydkigome	894	3	human	human	JJ
cord-264884-ydkigome	894	4	and	and	CC
cord-264884-ydkigome	894	5	rodent	rodent	NN
cord-264884-ydkigome	894	6	viruses	virus	NNS
cord-264884-ydkigome	894	7	,	,	,
cord-264884-ydkigome	894	8	a	a	DT
cord-264884-ydkigome	894	9	highly	highly	RB
cord-264884-ydkigome	894	10	conserved	conserve	VBN
cord-264884-ydkigome	894	11	gene	gene	NN
cord-264884-ydkigome	894	12	function	function	NN
cord-264884-ydkigome	894	13	associated	associate	VBN
cord-264884-ydkigome	894	14	with	with	IN
cord-264884-ydkigome	894	15	replication	replication	NN
cord-264884-ydkigome	894	16	and	and	CC
cord-264884-ydkigome	894	17	cell	cell	NN
cord-264884-ydkigome	894	18	control	control	NN
cord-264884-ydkigome	894	19	are	be	VBP
cord-264884-ydkigome	894	20	the	the	DT
cord-264884-ydkigome	894	21	E6	E6	NNP
cord-264884-ydkigome	894	22	and	and	CC
cord-264884-ydkigome	894	23	E7	E7	NNP
cord-264884-ydkigome	894	24	early	early	JJ
cord-264884-ydkigome	894	25	genes	gene	NNS
cord-264884-ydkigome	894	26	.	.	.
cord-264884-ydkigome	895	1	In	in	IN
cord-264884-ydkigome	895	2	particular	particular	JJ
cord-264884-ydkigome	895	3	,	,	,
cord-264884-ydkigome	895	4	the	the	DT
cord-264884-ydkigome	895	5	pRB	prb	NN
cord-264884-ydkigome	895	6	-	-	HYPH
cord-264884-ydkigome	895	7	binding	bind	VBG
cord-264884-ydkigome	895	8	domain	domain	NN
cord-264884-ydkigome	895	9	of	of	IN
cord-264884-ydkigome	895	10	the	the	DT
cord-264884-ydkigome	895	11	E7	E7	NNP
cord-264884-ydkigome	895	12	gene	gene	NN
cord-264884-ydkigome	895	13	is	be	VBZ
cord-264884-ydkigome	895	14	thought	think	VBN
cord-264884-ydkigome	895	15	to	to	TO
cord-264884-ydkigome	895	16	be	be	VB
cord-264884-ydkigome	895	17	central	central	JJ
cord-264884-ydkigome	895	18	to	to	IN
cord-264884-ydkigome	895	19	the	the	DT
cord-264884-ydkigome	895	20	biological	biological	JJ
cord-264884-ydkigome	895	21	strategy	strategy	NN
cord-264884-ydkigome	895	22	of	of	IN
cord-264884-ydkigome	895	23	the	the	DT
cord-264884-ydkigome	895	24	virus	virus	NN
cord-264884-ydkigome	895	25	.	.	.
cord-264884-ydkigome	896	1	Thus	thus	RB
cord-264884-ydkigome	896	2	,	,	,
cord-264884-ydkigome	896	3	it	-PRON-	PRP
cord-264884-ydkigome	896	4	is	be	VBZ
cord-264884-ydkigome	896	5	most	most	RBS
cord-264884-ydkigome	896	6	curious	curious	JJ
cord-264884-ydkigome	896	7	that	that	IN
cord-264884-ydkigome	896	8	the	the	DT
cord-264884-ydkigome	896	9	papillomaviruses	papillomaviruse	NNS
cord-264884-ydkigome	896	10	of	of	IN
cord-264884-ydkigome	896	11	lagomorphs	lagomorph	NNS
cord-264884-ydkigome	896	12	,	,	,
cord-264884-ydkigome	896	13	such	such	JJ
cord-264884-ydkigome	896	14	as	as	IN
cord-264884-ydkigome	896	15	bovine	bovine	JJ
cord-264884-ydkigome	896	16	and	and	CC
cord-264884-ydkigome	896	17	reindeer	reindeer	NN
cord-264884-ydkigome	896	18	papillomavirus	papillomavirus	NN
cord-264884-ydkigome	896	19	,	,	,
cord-264884-ydkigome	896	20	lack	lack	VBP
cord-264884-ydkigome	896	21	an	an	DT
cord-264884-ydkigome	896	22	E7	E7	NNP
cord-264884-ydkigome	896	23	Rb	Rb	NNP
cord-264884-ydkigome	896	24	-	-	HYPH
cord-264884-ydkigome	896	25	binding	bind	VBG
cord-264884-ydkigome	896	26	domain	domain	NN
cord-264884-ydkigome	896	27	and	and	CC
cord-264884-ydkigome	896	28	instead	instead	RB
cord-264884-ydkigome	896	29	appear	appear	VB
cord-264884-ydkigome	896	30	to	to	TO
cord-264884-ydkigome	896	31	use	use	VB
cord-264884-ydkigome	896	32	E5	E5	NNP
cord-264884-ydkigome	896	33	or	or	CC
cord-264884-ydkigome	896	34	E9	E9	NNP
cord-264884-ydkigome	896	35	genes	gene	NNS
cord-264884-ydkigome	896	36	for	for	IN
cord-264884-ydkigome	896	37	this	this	DT
cord-264884-ydkigome	896	38	regulatory	regulatory	JJ
cord-264884-ydkigome	896	39	function	function	NN
cord-264884-ydkigome	896	40	(	(	-LRB-
cord-264884-ydkigome	896	41	Narechania	Narechania	NNP
cord-264884-ydkigome	896	42	et	et	NNP
cord-264884-ydkigome	896	43	al	al	NNP
cord-264884-ydkigome	896	44	.	.	NNP
cord-264884-ydkigome	896	45	,	,	,
cord-264884-ydkigome	896	46	2004	2004	CD
cord-264884-ydkigome	896	47	)	)	-RRB-
cord-264884-ydkigome	896	48	.	.	.
cord-264884-ydkigome	897	1	It	-PRON-	PRP
cord-264884-ydkigome	897	2	seems	seem	VBZ
cord-264884-ydkigome	897	3	an	an	DT
cord-264884-ydkigome	897	4	early	early	JJ
cord-264884-ydkigome	897	5	but	but	CC
cord-264884-ydkigome	897	6	signifi	signifi	NNP
cord-264884-ydkigome	897	7	ca	can	MD
cord-264884-ydkigome	897	8	nt	not	RB
cord-264884-ydkigome	897	9	and	and	CC
cord-264884-ydkigome	897	10	bifurcating	bifurcate	VBG
cord-264884-ydkigome	897	11	shift	shift	NN
cord-264884-ydkigome	897	12	occurred	occur	VBD
cord-264884-ydkigome	897	13	in	in	IN
cord-264884-ydkigome	897	14	the	the	DT
cord-264884-ydkigome	897	15	molecular	molecular	JJ
cord-264884-ydkigome	897	16	strategy	strategy	NN
cord-264884-ydkigome	897	17	during	during	IN
cord-264884-ydkigome	897	18	the	the	DT
cord-264884-ydkigome	897	19	virus	virus	NN
cord-264884-ydkigome	897	20	-	-	HYPH
cord-264884-ydkigome	897	21	host	host	NN
cord-264884-ydkigome	897	22	evolution	evolution	NN
cord-264884-ydkigome	897	23	of	of	IN
cord-264884-ydkigome	897	24	this	this	DT
cord-264884-ydkigome	897	25	group	group	NN
cord-264884-ydkigome	897	26	of	of	IN
cord-264884-ydkigome	897	27	viruses	virus	NNS
cord-264884-ydkigome	897	28	for	for	IN
cord-264884-ydkigome	897	29	unknown	unknown	JJ
cord-264884-ydkigome	897	30	reasons	reason	NNS
cord-264884-ydkigome	897	31	.	.	.
cord-264884-ydkigome	898	1	Other	other	JJ
cord-264884-ydkigome	898	2	small	small	JJ
cord-264884-ydkigome	898	3	DNA	dna	NN
cord-264884-ydkigome	898	4	viruses	virus	NNS
cord-264884-ydkigome	898	5	(	(	-LRB-
cord-264884-ydkigome	898	6	JCV	JCV	NNP
cord-264884-ydkigome	898	7	,	,	,
cord-264884-ydkigome	898	8	BKV	BKV	NNP
cord-264884-ydkigome	898	9	,	,	,
cord-264884-ydkigome	898	10	Py	py	NN
cord-264884-ydkigome	898	11	)	)	-RRB-
cord-264884-ydkigome	898	12	can	can	MD
cord-264884-ydkigome	898	13	also	also	RB
cord-264884-ydkigome	898	14	show	show	VB
cord-264884-ydkigome	898	15	similar	similar	JJ
cord-264884-ydkigome	898	16	high	high	JJ
cord-264884-ydkigome	898	17	-	-	HYPH
cord-264884-ydkigome	898	18	resolution	resolution	NN
cord-264884-ydkigome	898	19	host	host	NN
cord-264884-ydkigome	898	20	congruence	congruence	NN
cord-264884-ydkigome	898	21	(	(	-LRB-
cord-264884-ydkigome	898	22	Shadan	Shadan	NNP
cord-264884-ydkigome	898	23	and	and	CC
cord-264884-ydkigome	898	24	Villarreal	Villarreal	NNP
cord-264884-ydkigome	898	25	,	,	,
cord-264884-ydkigome	898	26	1995	1995	CD
cord-264884-ydkigome	898	27	)	)	-RRB-
cord-264884-ydkigome	898	28	.	.	.
cord-264884-ydkigome	899	1	As	as	RB
cord-264884-ydkigome	899	2	well	well	RB
cord-264884-ydkigome	899	3	as	as	IN
cord-264884-ydkigome	899	4	similar	similar	JJ
cord-264884-ydkigome	899	5	curious	curious	JJ
cord-264884-ydkigome	899	6	shifts	shift	NNS
cord-264884-ydkigome	899	7	in	in	IN
cord-264884-ydkigome	899	8	basic	basic	JJ
cord-264884-ydkigome	899	9	molecular	molecular	JJ
cord-264884-ydkigome	899	10	strategies	strategy	NNS
cord-264884-ydkigome	899	11	.	.	.
cord-264884-ydkigome	900	1	For	for	IN
cord-264884-ydkigome	900	2	example	example	NN
cord-264884-ydkigome	900	3	,	,	,
cord-264884-ydkigome	900	4	the	the	DT
cord-264884-ydkigome	900	5	presence	presence	NN
cord-264884-ydkigome	900	6	of	of	IN
cord-264884-ydkigome	900	7	a	a	DT
cord-264884-ydkigome	900	8	middle	middle	JJ
cord-264884-ydkigome	900	9	Tantigen	Tantigen	NNP
cord-264884-ydkigome	900	10	in	in	IN
cord-264884-ydkigome	900	11	mouse	mouse	NN
cord-264884-ydkigome	900	12	virus	virus	NN
cord-264884-ydkigome	900	13	(	(	-LRB-
cord-264884-ydkigome	900	14	a	a	DT
cord-264884-ydkigome	900	15	third	third	JJ
cord-264884-ydkigome	900	16	early	early	JJ
cord-264884-ydkigome	900	17	gene	gene	NN
cord-264884-ydkigome	900	18	)	)	-RRB-
cord-264884-ydkigome	900	19	,	,	,
cord-264884-ydkigome	900	20	but	but	CC
cord-264884-ydkigome	900	21	its	-PRON-	PRP$
cord-264884-ydkigome	900	22	absence	absence	NN
cord-264884-ydkigome	900	23	from	from	IN
cord-264884-ydkigome	900	24	primate	primate	JJ
cord-264884-ydkigome	900	25	viruses	virus	NNS
cord-264884-ydkigome	900	26	(	(	-LRB-
cord-264884-ydkigome	900	27	Gottlieb	Gottlieb	NNP
cord-264884-ydkigome	900	28	and	and	CC
cord-264884-ydkigome	900	29	Villarreal	Villarreal	NNP
cord-264884-ydkigome	900	30	,	,	,
cord-264884-ydkigome	900	31	2001	2001	CD
cord-264884-ydkigome	900	32	)	)	-RRB-
cord-264884-ydkigome	900	33	,	,	,
cord-264884-ydkigome	900	34	clearly	clearly	RB
cord-264884-ydkigome	900	35	differentiates	differentiate	VBZ
cord-264884-ydkigome	900	36	these	these	DT
cord-264884-ydkigome	900	37	viral	viral	JJ
cord-264884-ydkigome	900	38	lineages	lineage	NNS
cord-264884-ydkigome	900	39	.	.	.
cord-264884-ydkigome	901	1	Although	although	IN
cord-264884-ydkigome	901	2	the	the	DT
cord-264884-ydkigome	901	3	origins	origin	NNS
cord-264884-ydkigome	901	4	of	of	IN
cord-264884-ydkigome	901	5	these	these	DT
cord-264884-ydkigome	901	6	entire	entire	JJ
cord-264884-ydkigome	901	7	small	small	JJ
cord-264884-ydkigome	901	8	DNA	dna	NN
cord-264884-ydkigome	901	9	viruses	virus	NNS
cord-264884-ydkigome	901	10	are	be	VBP
cord-264884-ydkigome	901	11	obscure	obscure	JJ
cord-264884-ydkigome	901	12	,	,	,
cord-264884-ydkigome	901	13	and	and	CC
cord-264884-ydkigome	901	14	any	any	DT
cord-264884-ydkigome	901	15	links	link	NNS
cord-264884-ydkigome	901	16	to	to	IN
cord-264884-ydkigome	901	17	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	901	18	viruses	virus	NNS
cord-264884-ydkigome	901	19	are	be	VBP
cord-264884-ydkigome	901	20	unknown	unknown	JJ
cord-264884-ydkigome	901	21	,	,	,
cord-264884-ydkigome	901	22	it	-PRON-	PRP
cord-264884-ydkigome	901	23	does	do	VBZ
cord-264884-ydkigome	901	24	appear	appear	VB
cord-264884-ydkigome	901	25	they	-PRON-	PRP
cord-264884-ydkigome	901	26	have	have	VBP
cord-264884-ydkigome	901	27	tended	tend	VBN
cord-264884-ydkigome	901	28	to	to	TO
cord-264884-ydkigome	901	29	retain	retain	VB
cord-264884-ydkigome	901	30	their	-PRON-	PRP$
cord-264884-ydkigome	901	31	overall	overall	JJ
cord-264884-ydkigome	901	32	biological	biological	JJ
cord-264884-ydkigome	901	33	strategy	strategy	NN
cord-264884-ydkigome	901	34	and	and	CC
cord-264884-ydkigome	901	35	show	show	VBP
cord-264884-ydkigome	901	36	a	a	DT
cord-264884-ydkigome	901	37	strong	strong	JJ
cord-264884-ydkigome	901	38	tendency	tendency	NN
cord-264884-ydkigome	901	39	for	for	IN
cord-264884-ydkigome	901	40	tissue	tissue	NN
cord-264884-ydkigome	901	41	-	-	HYPH
cord-264884-ydkigome	901	42	specifi	specifi	NN
cord-264884-ydkigome	901	43	c	c	NN
cord-264884-ydkigome	901	44	(	(	-LRB-
cord-264884-ydkigome	901	45	especially	especially	RB
cord-264884-ydkigome	901	46	kidney	kidney	NN
cord-264884-ydkigome	901	47	)	)	-RRB-
cord-264884-ydkigome	901	48	persistence	persistence	NN
cord-264884-ydkigome	901	49	and	and	CC
cord-264884-ydkigome	901	50	virus	virus	NN
cord-264884-ydkigome	901	51	-	-	HYPH
cord-264884-ydkigome	901	52	host	host	NN
cord-264884-ydkigome	901	53	congruence	congruence	NN
cord-264884-ydkigome	901	54	.	.	.
cord-264884-ydkigome	902	1	Since	since	IN
cord-264884-ydkigome	902	2	persistence	persistence	NN
cord-264884-ydkigome	902	3	requires	require	VBZ
cord-264884-ydkigome	902	4	the	the	DT
cord-264884-ydkigome	902	5	stable	stable	JJ
cord-264884-ydkigome	902	6	coexistence	coexistence	NN
cord-264884-ydkigome	902	7	of	of	IN
cord-264884-ydkigome	902	8	a	a	DT
cord-264884-ydkigome	902	9	virus	virus	NN
cord-264884-ydkigome	902	10	and	and	CC
cord-264884-ydkigome	902	11	its	-PRON-	PRP$
cord-264884-ydkigome	902	12	host	host	NN
cord-264884-ydkigome	902	13	,	,	,
cord-264884-ydkigome	902	14	it	-PRON-	PRP
cord-264884-ydkigome	902	15	also	also	RB
cord-264884-ydkigome	902	16	fi	fi	VBP
cord-264884-ydkigome	902	17	ts	ts	NNP
cord-264884-ydkigome	902	18	the	the	DT
cord-264884-ydkigome	902	19	simple	simple	JJ
cord-264884-ydkigome	902	20	defi	defi	NNP
cord-264884-ydkigome	902	21	nition	nition	NN
cord-264884-ydkigome	902	22	of	of	IN
cord-264884-ydkigome	902	23	symbiosis	symbiosis	NN
cord-264884-ydkigome	902	24	(	(	-LRB-
cord-264884-ydkigome	902	25	the	the	DT
cord-264884-ydkigome	902	26	stable	stable	JJ
cord-264884-ydkigome	902	27	living	living	NN
cord-264884-ydkigome	902	28	together	together	RB
cord-264884-ydkigome	902	29	of	of	IN
cord-264884-ydkigome	902	30	two	two	CD
cord-264884-ydkigome	902	31	distinct	distinct	JJ
cord-264884-ydkigome	902	32	lineages	lineage	NNS
cord-264884-ydkigome	902	33	of	of	IN
cord-264884-ydkigome	902	34	organisms	organism	NNS
cord-264884-ydkigome	902	35	)	)	-RRB-
cord-264884-ydkigome	902	36	.	.	.
cord-264884-ydkigome	903	1	Viral	viral	JJ
cord-264884-ydkigome	903	2	involvement	involvement	NN
cord-264884-ydkigome	903	3	in	in	IN
cord-264884-ydkigome	903	4	symbiosis	symbiosis	NN
cord-264884-ydkigome	903	5	is	be	VBZ
cord-264884-ydkigome	903	6	a	a	DT
cord-264884-ydkigome	903	7	foreign	foreign	JJ
cord-264884-ydkigome	903	8	idea	idea	NN
cord-264884-ydkigome	903	9	to	to	IN
cord-264884-ydkigome	903	10	many	many	JJ
cord-264884-ydkigome	903	11	and	and	CC
cord-264884-ydkigome	903	12	possibly	possibly	RB
cord-264884-ydkigome	903	13	presents	present	VBZ
cord-264884-ydkigome	903	14	a	a	DT
cord-264884-ydkigome	903	15	fundamentally	fundamentally	RB
cord-264884-ydkigome	903	16	different	different	JJ
cord-264884-ydkigome	903	17	view	view	NN
cord-264884-ydkigome	903	18	of	of	IN
cord-264884-ydkigome	903	19	the	the	DT
cord-264884-ydkigome	903	20	role	role	NN
cord-264884-ydkigome	903	21	viruses	virus	NNS
cord-264884-ydkigome	903	22	may	may	MD
cord-264884-ydkigome	903	23	have	have	VB
cord-264884-ydkigome	903	24	in	in	IN
cord-264884-ydkigome	903	25	host	host	NN
cord-264884-ydkigome	903	26	evolution	evolution	NN
cord-264884-ydkigome	903	27	.	.	.
cord-264884-ydkigome	904	1	A	a	DT
cord-264884-ydkigome	904	2	major	major	JJ
cord-264884-ydkigome	904	3	role	role	NN
cord-264884-ydkigome	904	4	for	for	IN
cord-264884-ydkigome	904	5	persisting	persist	VBG
cord-264884-ydkigome	904	6	(	(	-LRB-
cord-264884-ydkigome	904	7	temperate	temperate	JJ
cord-264884-ydkigome	904	8	,	,	,
cord-264884-ydkigome	904	9	cryptic	cryptic	JJ
cord-264884-ydkigome	904	10	)	)	-RRB-
cord-264884-ydkigome	904	11	viruses	virus	NNS
cord-264884-ydkigome	904	12	in	in	IN
cord-264884-ydkigome	904	13	the	the	DT
cord-264884-ydkigome	904	14	evolution	evolution	NN
cord-264884-ydkigome	904	15	of	of	IN
cord-264884-ydkigome	904	16	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	904	17	is	be	VBZ
cord-264884-ydkigome	904	18	no	no	RB
cord-264884-ydkigome	904	19	longer	long	RBR
cord-264884-ydkigome	904	20	a	a	DT
cord-264884-ydkigome	904	21	controversial	controversial	JJ
cord-264884-ydkigome	904	22	idea	idea	NN
cord-264884-ydkigome	904	23	.	.	.
cord-264884-ydkigome	905	1	Thus	thus	RB
cord-264884-ydkigome	905	2	,	,	,
cord-264884-ydkigome	905	3	at	at	IN
cord-264884-ydkigome	905	4	least	least	JJS
cord-264884-ydkigome	905	5	in	in	IN
cord-264884-ydkigome	905	6	the	the	DT
cord-264884-ydkigome	905	7	prokaryotic	prokaryotic	JJ
cord-264884-ydkigome	905	8	world	world	NN
cord-264884-ydkigome	905	9	,	,	,
cord-264884-ydkigome	905	10	virus	virus	NN
cord-264884-ydkigome	905	11	persistence	persistence	NN
cord-264884-ydkigome	905	12	can	can	MD
cord-264884-ydkigome	905	13	be	be	VB
cord-264884-ydkigome	905	14	accepted	accept	VBN
cord-264884-ydkigome	905	15	as	as	IN
cord-264884-ydkigome	905	16	adaptive	adaptive	JJ
cord-264884-ydkigome	905	17	.	.	.
cord-264884-ydkigome	906	1	In	in	IN
cord-264884-ydkigome	906	2	eukaryotes	eukaryote	NNS
cord-264884-ydkigome	906	3	,	,	,
cord-264884-ydkigome	906	4	however	however	RB
cord-264884-ydkigome	906	5	,	,	,
cord-264884-ydkigome	906	6	viral	viral	JJ
cord-264884-ydkigome	906	7	persistence	persistence	NN
cord-264884-ydkigome	906	8	is	be	VBZ
cord-264884-ydkigome	906	9	seldom	seldom	RB
cord-264884-ydkigome	906	10	considered	consider	VBN
cord-264884-ydkigome	906	11	adaptive	adaptive	JJ
cord-264884-ydkigome	906	12	.	.	.
cord-264884-ydkigome	907	1	The	the	DT
cord-264884-ydkigome	907	2	MHV	MHV	NNP
cord-264884-ydkigome	907	3	-	-	HYPH
cord-264884-ydkigome	907	4	mouse	mouse	NN
cord-264884-ydkigome	907	5	exemplar	exemplar	NN
cord-264884-ydkigome	907	6	as	as	IN
cord-264884-ydkigome	907	7	presented	present	VBN
cord-264884-ydkigome	907	8	above	above	RB
cord-264884-ydkigome	907	9	has	have	VBZ
cord-264884-ydkigome	907	10	suggested	suggest	VBN
cord-264884-ydkigome	907	11	how	how	WRB
cord-264884-ydkigome	907	12	persistence	persistence	NN
cord-264884-ydkigome	907	13	can	can	MD
cord-264884-ydkigome	907	14	directly	directly	RB
cord-264884-ydkigome	907	15	affect	affect	VB
cord-264884-ydkigome	907	16	host	host	NN
cord-264884-ydkigome	907	17	survival	survival	NN
cord-264884-ydkigome	907	18	.	.	.
cord-264884-ydkigome	908	1	Can	Can	MD
cord-264884-ydkigome	908	2	this	this	DT
cord-264884-ydkigome	908	3	be	be	VB
cord-264884-ydkigome	908	4	considered	consider	VBN
cord-264884-ydkigome	908	5	an	an	DT
cord-264884-ydkigome	908	6	example	example	NN
cord-264884-ydkigome	908	7	of	of	IN
cord-264884-ydkigome	908	8	symbiosis	symbiosis	NN
cord-264884-ydkigome	908	9	in	in	IN
cord-264884-ydkigome	908	10	the	the	DT
cord-264884-ydkigome	908	11	accepted	accepted	JJ
cord-264884-ydkigome	908	12	sense	sense	NN
cord-264884-ydkigome	908	13	?	?	.
cord-264884-ydkigome	909	1	A	a	DT
cord-264884-ydkigome	909	2	crowning	crowning	JJ
cord-264884-ydkigome	909	3	achievement	achievement	NN
cord-264884-ydkigome	909	4	in	in	IN
cord-264884-ydkigome	909	5	the	the	DT
cord-264884-ydkigome	909	6	fi	fi	NNP
cord-264884-ydkigome	909	7	eld	eld	NN
cord-264884-ydkigome	909	8	of	of	IN
cord-264884-ydkigome	909	9	symbiosis	symbiosis	NN
cord-264884-ydkigome	909	10	has	have	VBZ
cord-264884-ydkigome	909	11	been	be	VBN
cord-264884-ydkigome	909	12	to	to	TO
cord-264884-ydkigome	909	13	explain	explain	VB
cord-264884-ydkigome	909	14	the	the	DT
cord-264884-ydkigome	909	15	origin	origin	NN
cord-264884-ydkigome	909	16	of	of	IN
cord-264884-ydkigome	909	17	plastids	plastid	NNS
cord-264884-ydkigome	909	18	(	(	-LRB-
cord-264884-ydkigome	909	19	chloroplasts	chloroplast	NNS
cord-264884-ydkigome	909	20	,	,	,
cord-264884-ydkigome	909	21	mitochondria	mitochondrion	NNS
cord-264884-ydkigome	909	22	)	)	-RRB-
cord-264884-ydkigome	909	23	from	from	IN
cord-264884-ydkigome	909	24	symbiotic	symbiotic	JJ
cord-264884-ydkigome	909	25	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	909	26	in	in	IN
cord-264884-ydkigome	909	27	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	909	28	cytoplasm	cytoplasm	NN
cord-264884-ydkigome	910	1	(	(	-LRB-
cord-264884-ydkigome	910	2	Margulis	Margulis	NNP
cord-264884-ydkigome	910	3	and	and	CC
cord-264884-ydkigome	910	4	Bermudes	Bermudes	NNP
cord-264884-ydkigome	910	5	,	,	,
cord-264884-ydkigome	910	6	1985	1985	CD
cord-264884-ydkigome	910	7	)	)	-RRB-
cord-264884-ydkigome	910	8	.	.	.
cord-264884-ydkigome	911	1	This	this	DT
cord-264884-ydkigome	911	2	idea	idea	NN
cord-264884-ydkigome	911	3	involves	involve	VBZ
cord-264884-ydkigome	911	4	the	the	DT
cord-264884-ydkigome	911	5	high	high	JJ
cord-264884-ydkigome	911	6	adaptability	adaptability	NN
cord-264884-ydkigome	911	7	of	of	IN
cord-264884-ydkigome	911	8	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	911	9	to	to	TO
cord-264884-ydkigome	911	10	provide	provide	VB
cord-264884-ydkigome	911	11	innovation	innovation	NN
cord-264884-ydkigome	911	12	but	but	CC
cord-264884-ydkigome	911	13	would	would	MD
cord-264884-ydkigome	911	14	seem	seem	VB
cord-264884-ydkigome	911	15	not	not	RB
cord-264884-ydkigome	911	16	to	to	TO
cord-264884-ydkigome	911	17	involve	involve	VB
cord-264884-ydkigome	911	18	virus	virus	NN
cord-264884-ydkigome	911	19	in	in	IN
cord-264884-ydkigome	911	20	any	any	DT
cord-264884-ydkigome	911	21	way	way	NN
cord-264884-ydkigome	911	22	.	.	.
cord-264884-ydkigome	912	1	Yet	yet	CC
cord-264884-ydkigome	912	2	here	here	RB
cord-264884-ydkigome	912	3	too	too	RB
cord-264884-ydkigome	912	4	we	-PRON-	PRP
cord-264884-ydkigome	912	5	can	can	MD
cord-264884-ydkigome	912	6	fi	fi	VB
cord-264884-ydkigome	912	7	nd	nd	NNP
cord-264884-ydkigome	912	8	viral	viral	JJ
cord-264884-ydkigome	912	9	footprints	footprint	NNS
cord-264884-ydkigome	912	10	that	that	WDT
cord-264884-ydkigome	912	11	suggest	suggest	VBP
cord-264884-ydkigome	912	12	some	some	DT
cord-264884-ydkigome	912	13	involvement	involvement	NN
cord-264884-ydkigome	912	14	.	.	.
cord-264884-ydkigome	913	1	For	for	IN
cord-264884-ydkigome	913	2	example	example	NN
cord-264884-ydkigome	913	3	,	,	,
cord-264884-ydkigome	913	4	various	various	JJ
cord-264884-ydkigome	913	5	plastid	plastid	NN
cord-264884-ydkigome	913	6	-	-	HYPH
cord-264884-ydkigome	913	7	specifi	specifi	NN
cord-264884-ydkigome	913	8	c	c	NN
cord-264884-ydkigome	913	9	RNA	RNA	NNP
cord-264884-ydkigome	913	10	and	and	CC
cord-264884-ydkigome	913	11	DNA	dna	NN
cord-264884-ydkigome	913	12	polymerases	polymerase	NNS
cord-264884-ydkigome	913	13	clearly	clearly	RB
cord-264884-ydkigome	913	14	resemble	resemble	VBP
cord-264884-ydkigome	913	15	polymerases	polymerase	NNS
cord-264884-ydkigome	913	16	from	from	IN
cord-264884-ydkigome	913	17	T3	T3	NNP
cord-264884-ydkigome	913	18	/	/	SYM
cord-264884-ydkigome	913	19	T7-like	t7-like	IN
cord-264884-ydkigome	913	20	phage	phage	NN
cord-264884-ydkigome	913	21	(	(	-LRB-
cord-264884-ydkigome	913	22	Cermakian	Cermakian	NNP
cord-264884-ydkigome	913	23	et	et	FW
cord-264884-ydkigome	913	24	al	al	NNP
cord-264884-ydkigome	913	25	.	.	NNP
cord-264884-ydkigome	913	26	,	,	,
cord-264884-ydkigome	913	27	1996	1996	CD
cord-264884-ydkigome	913	28	;	;	:
cord-264884-ydkigome	913	29	Shutt	Shutt	NNP
cord-264884-ydkigome	913	30	and	and	CC
cord-264884-ydkigome	913	31	Gray	Gray	NNP
cord-264884-ydkigome	913	32	,	,	,
cord-264884-ydkigome	913	33	2006	2006	CD
cord-264884-ydkigome	913	34	)	)	-RRB-
cord-264884-ydkigome	913	35	.	.	.
cord-264884-ydkigome	914	1	Other	other	JJ
cord-264884-ydkigome	914	2	models	model	NNS
cord-264884-ydkigome	914	3	of	of	IN
cord-264884-ydkigome	914	4	symbiosis	symbiosis	NN
cord-264884-ydkigome	914	5	also	also	RB
cord-264884-ydkigome	914	6	show	show	VBP
cord-264884-ydkigome	914	7	evidence	evidence	NN
cord-264884-ydkigome	914	8	of	of	IN
cord-264884-ydkigome	914	9	a	a	DT
cord-264884-ydkigome	914	10	viral	viral	JJ
cord-264884-ydkigome	914	11	role	role	NN
cord-264884-ydkigome	914	12	,	,	,
cord-264884-ydkigome	914	13	such	such	JJ
cord-264884-ydkigome	914	14	as	as	IN
cord-264884-ydkigome	914	15	the	the	DT
cord-264884-ydkigome	914	16	sexual	sexual	JJ
cord-264884-ydkigome	914	17	isolation	isolation	NN
cord-264884-ydkigome	914	18	of	of	IN
cord-264884-ydkigome	914	19	Buchnera	Buchnera	NNP
cord-264884-ydkigome	914	20	(	(	-LRB-
cord-264884-ydkigome	914	21	Moran	Moran	NNP
cord-264884-ydkigome	914	22	et	et	NNP
cord-264884-ydkigome	914	23	al	al	NNP
cord-264884-ydkigome	914	24	.	.	NNP
cord-264884-ydkigome	914	25	,	,	,
cord-264884-ydkigome	914	26	2005	2005	CD
cord-264884-ydkigome	914	27	)	)	-RRB-
cord-264884-ydkigome	914	28	.	.	.
cord-264884-ydkigome	915	1	Another	another	DT
cord-264884-ydkigome	915	2	very	very	RB
cord-264884-ydkigome	915	3	popular	popular	JJ
cord-264884-ydkigome	915	4	topic	topic	NN
cord-264884-ydkigome	915	5	in	in	IN
cord-264884-ydkigome	915	6	the	the	DT
cord-264884-ydkigome	915	7	fi	fi	NNP
cord-264884-ydkigome	915	8	eld	eld	NN
cord-264884-ydkigome	915	9	of	of	IN
cord-264884-ydkigome	915	10	symbiosis	symbiosis	NN
cord-264884-ydkigome	915	11	is	be	VBZ
cord-264884-ydkigome	915	12	the	the	DT
cord-264884-ydkigome	915	13	symbiotic	symbiotic	JJ
cord-264884-ydkigome	915	14	origin	origin	NN
cord-264884-ydkigome	915	15	of	of	IN
cord-264884-ydkigome	915	16	the	the	DT
cord-264884-ydkigome	915	17	photosynthetic	photosynthetic	JJ
cord-264884-ydkigome	915	18	sea	sea	NN
cord-264884-ydkigome	915	19	slug	slug	NN
cord-264884-ydkigome	915	20	,	,	,
cord-264884-ydkigome	915	21	Elysa	Elysa	NNP
cord-264884-ydkigome	915	22	chlorotica	chlorotica	NNP
cord-264884-ydkigome	915	23	.	.	.
cord-264884-ydkigome	916	1	What	what	WP
cord-264884-ydkigome	916	2	could	could	MD
cord-264884-ydkigome	916	3	be	be	VB
cord-264884-ydkigome	916	4	more	more	RBR
cord-264884-ydkigome	916	5	fascinating	fascinating	JJ
cord-264884-ydkigome	916	6	than	than	IN
cord-264884-ydkigome	916	7	a	a	DT
cord-264884-ydkigome	916	8	green	green	JJ
cord-264884-ydkigome	916	9	sea	sea	NN
cord-264884-ydkigome	916	10	slug	slug	NN
cord-264884-ydkigome	916	11	-	-	:
cord-264884-ydkigome	916	12	an	an	DT
cord-264884-ydkigome	916	13	animal	animal	NN
cord-264884-ydkigome	916	14	that	that	WDT
cord-264884-ydkigome	916	15	can	can	MD
cord-264884-ydkigome	916	16	use	use	VB
cord-264884-ydkigome	916	17	light	light	NN
cord-264884-ydkigome	916	18	for	for	IN
cord-264884-ydkigome	916	19	photosynthesis	photosynthesis	NN
cord-264884-ydkigome	916	20	?	?	.
cord-264884-ydkigome	917	1	E.	E.	NNP
cord-264884-ydkigome	917	2	chlorotica	chlorotica	NNP
cord-264884-ydkigome	917	3	eats	eat	VBZ
cord-264884-ydkigome	917	4	photosynthetic	photosynthetic	JJ
cord-264884-ydkigome	917	5	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	917	6	algae	algae	NN
cord-264884-ydkigome	917	7	(	(	-LRB-
cord-264884-ydkigome	917	8	Vaucheria	Vaucheria	NNP
cord-264884-ydkigome	917	9	litorea	litorea	NNP
cord-264884-ydkigome	917	10	)	)	-RRB-
cord-264884-ydkigome	917	11	and	and	CC
cord-264884-ydkigome	917	12	retains	retain	VBZ
cord-264884-ydkigome	917	13	the	the	DT
cord-264884-ydkigome	917	14	functional	functional	JJ
cord-264884-ydkigome	917	15	chloroplast	chloroplast	NN
cord-264884-ydkigome	917	16	from	from	IN
cord-264884-ydkigome	917	17	algae	algae	NN
cord-264884-ydkigome	917	18	for	for	IN
cord-264884-ydkigome	917	19	months	month	NNS
cord-264884-ydkigome	917	20	.	.	.
cord-264884-ydkigome	918	1	Here	here	RB
cord-264884-ydkigome	918	2	too	too	RB
cord-264884-ydkigome	918	3	,	,	,
cord-264884-ydkigome	918	4	however	however	RB
cord-264884-ydkigome	918	5	,	,	,
cord-264884-ydkigome	918	6	there	there	EX
cord-264884-ydkigome	918	7	lies	lie	VBZ
cord-264884-ydkigome	918	8	a	a	DT
cord-264884-ydkigome	918	9	viral	viral	JJ
cord-264884-ydkigome	918	10	footprint	footprint	NN
cord-264884-ydkigome	918	11	.	.	.
cord-264884-ydkigome	919	1	This	this	DT
cord-264884-ydkigome	919	2	slug	slug	NN
cord-264884-ydkigome	919	3	harbors	harbor	VBZ
cord-264884-ydkigome	919	4	an	an	DT
cord-264884-ydkigome	919	5	unusual	unusual	JJ
cord-264884-ydkigome	919	6	endogenous	endogenous	JJ
cord-264884-ydkigome	919	7	retrovirus	retrovirus	NN
cord-264884-ydkigome	919	8	which	which	WDT
cord-264884-ydkigome	919	9	is	be	VBZ
cord-264884-ydkigome	919	10	expressed	express	VBN
cord-264884-ydkigome	919	11	in	in	IN
cord-264884-ydkigome	919	12	large	large	JJ
cord-264884-ydkigome	919	13	numbers	number	NNS
cord-264884-ydkigome	919	14	during	during	IN
cord-264884-ydkigome	919	15	sexual	sexual	JJ
cord-264884-ydkigome	919	16	reproduction	reproduction	NN
cord-264884-ydkigome	919	17	,	,	,
cord-264884-ydkigome	919	18	following	follow	VBG
cord-264884-ydkigome	919	19	which	which	WDT
cord-264884-ydkigome	919	20	all	all	DT
cord-264884-ydkigome	919	21	slugs	slug	NNS
cord-264884-ydkigome	919	22	die	die	VBP
cord-264884-ydkigome	919	23	via	via	IN
cord-264884-ydkigome	919	24	synchronized	synchronize	VBN
cord-264884-ydkigome	919	25	apoptosis	apoptosis	NN
cord-264884-ydkigome	919	26	and	and	CC
cord-264884-ydkigome	919	27	in	in	IN
cord-264884-ydkigome	919	28	which	which	WDT
cord-264884-ydkigome	919	29	the	the	DT
cord-264884-ydkigome	919	30	chloroplasts	chloroplast	NNS
cord-264884-ydkigome	919	31	have	have	VBP
cord-264884-ydkigome	919	32	accumulated	accumulate	VBN
cord-264884-ydkigome	919	33	numerous	numerous	JJ
cord-264884-ydkigome	919	34	viral	viral	JJ
cord-264884-ydkigome	919	35	particles	particle	NNS
cord-264884-ydkigome	919	36	(	(	-LRB-
cord-264884-ydkigome	919	37	Pierce	Pierce	NNP
cord-264884-ydkigome	919	38	et	et	NNP
cord-264884-ydkigome	919	39	al	al	NNP
cord-264884-ydkigome	919	40	.	.	NNP
cord-264884-ydkigome	919	41	,	,	,
cord-264884-ydkigome	919	42	1999	1999	CD
cord-264884-ydkigome	919	43	;	;	:
cord-264884-ydkigome	919	44	Mondy	Mondy	NNP
cord-264884-ydkigome	919	45	and	and	CC
cord-264884-ydkigome	919	46	Pierce	Pierce	NNP
cord-264884-ydkigome	919	47	,	,	,
cord-264884-ydkigome	919	48	2003	2003	CD
cord-264884-ydkigome	919	49	)	)	-RRB-
cord-264884-ydkigome	919	50	.	.	.
cord-264884-ydkigome	920	1	Since	since	IN
cord-264884-ydkigome	920	2	there	there	EX
cord-264884-ydkigome	920	3	is	be	VBZ
cord-264884-ydkigome	920	4	reason	reason	NN
cord-264884-ydkigome	920	5	to	to	TO
cord-264884-ydkigome	920	6	think	think	VB
cord-264884-ydkigome	920	7	gene	gene	NN
cord-264884-ydkigome	920	8	movement	movement	NN
cord-264884-ydkigome	920	9	from	from	IN
cord-264884-ydkigome	920	10	the	the	DT
cord-264884-ydkigome	920	11	algae	algae	NN
cord-264884-ydkigome	920	12	to	to	IN
cord-264884-ydkigome	920	13	the	the	DT
cord-264884-ydkigome	920	14	slug	slug	NN
cord-264884-ydkigome	920	15	genome	genome	NN
cord-264884-ydkigome	920	16	is	be	VBZ
cord-264884-ydkigome	920	17	involved	involve	VBN
cord-264884-ydkigome	920	18	in	in	IN
cord-264884-ydkigome	920	19	this	this	DT
cord-264884-ydkigome	920	20	symbiosis	symbiosis	NN
cord-264884-ydkigome	920	21	,	,	,
cord-264884-ydkigome	920	22	the	the	DT
cord-264884-ydkigome	920	23	presence	presence	NN
cord-264884-ydkigome	920	24	of	of	IN
cord-264884-ydkigome	920	25	this	this	DT
cord-264884-ydkigome	920	26	retrovirus	retrovirus	NN
cord-264884-ydkigome	920	27	is	be	VBZ
cord-264884-ydkigome	920	28	a	a	DT
cord-264884-ydkigome	920	29	strong	strong	JJ
cord-264884-ydkigome	920	30	candidate	candidate	NN
cord-264884-ydkigome	920	31	to	to	TO
cord-264884-ydkigome	920	32	also	also	RB
cord-264884-ydkigome	920	33	be	be	VB
cord-264884-ydkigome	920	34	involved	involve	VBN
cord-264884-ydkigome	920	35	in	in	IN
cord-264884-ydkigome	920	36	symbiogenesis	symbiogenesis	NNP
cord-264884-ydkigome	920	37	.	.	.
cord-264884-ydkigome	921	1	Clearly	clearly	RB
cord-264884-ydkigome	921	2	we	-PRON-	PRP
cord-264884-ydkigome	921	3	should	should	MD
cord-264884-ydkigome	921	4	thus	thus	RB
cord-264884-ydkigome	921	5	investigate	investigate	VB
cord-264884-ydkigome	921	6	retroviral	retroviral	JJ
cord-264884-ydkigome	921	7	elements	element	NNS
cord-264884-ydkigome	921	8	as	as	IN
cord-264884-ydkigome	921	9	possible	possible	JJ
cord-264884-ydkigome	921	10	symbiotic	symbiotic	JJ
cord-264884-ydkigome	921	11	participants	participant	NNS
cord-264884-ydkigome	921	12	and	and	CC
cord-264884-ydkigome	921	13	not	not	RB
cord-264884-ydkigome	921	14	dismiss	dismiss	VB
cord-264884-ydkigome	921	15	them	-PRON-	PRP
cord-264884-ydkigome	921	16	beforehand	beforehand	RB
cord-264884-ydkigome	921	17	as	as	RB
cord-264884-ydkigome	921	18	irrelevant	irrelevant	JJ
cord-264884-ydkigome	921	19	or	or	CC
cord-264884-ydkigome	921	20	"	"	``
cord-264884-ydkigome	921	21	junk	junk	NN
cord-264884-ydkigome	921	22	DNA	dna	NN
cord-264884-ydkigome	921	23	"	"	''
cord-264884-ydkigome	921	24	(	(	-LRB-
cord-264884-ydkigome	921	25	as	as	IN
cord-264884-ydkigome	921	26	is	be	VBZ
cord-264884-ydkigome	921	27	automatically	automatically	RB
cord-264884-ydkigome	921	28	done	do	VBN
cord-264884-ydkigome	921	29	in	in	IN
cord-264884-ydkigome	921	30	many	many	JJ
cord-264884-ydkigome	921	31	database	database	NN
cord-264884-ydkigome	921	32	screens	screen	NNS
cord-264884-ydkigome	921	33	)	)	-RRB-
cord-264884-ydkigome	921	34	.	.	.
cord-264884-ydkigome	922	1	If	if	IN
cord-264884-ydkigome	922	2	viral	viral	JJ
cord-264884-ydkigome	922	3	persistence	persistence	NN
cord-264884-ydkigome	922	4	is	be	VBZ
cord-264884-ydkigome	922	5	a	a	DT
cord-264884-ydkigome	922	6	kind	kind	NN
cord-264884-ydkigome	922	7	of	of	IN
cord-264884-ydkigome	922	8	symbiosis	symbiosis	NN
cord-264884-ydkigome	922	9	,	,	,
cord-264884-ydkigome	922	10	viruses	virus	NNS
cord-264884-ydkigome	922	11	may	may	MD
cord-264884-ydkigome	922	12	also	also	RB
cord-264884-ydkigome	922	13	mediate	mediate	VB
cord-264884-ydkigome	922	14	the	the	DT
cord-264884-ydkigome	922	15	establishment	establishment	NN
cord-264884-ydkigome	922	16	of	of	IN
cord-264884-ydkigome	922	17	other	other	JJ
cord-264884-ydkigome	922	18	symbiotic	symbiotic	JJ
cord-264884-ydkigome	922	19	relationships	relationship	NNS
cord-264884-ydkigome	922	20	(	(	-LRB-
cord-264884-ydkigome	922	21	Villarreal	Villarreal	NNP
cord-264884-ydkigome	922	22	,	,	,
cord-264884-ydkigome	922	23	2007	2007	CD
cord-264884-ydkigome	922	24	)	)	-RRB-
cord-264884-ydkigome	922	25	.	.	.
cord-264884-ydkigome	923	1	The	the	DT
cord-264884-ydkigome	923	2	recent	recent	JJ
cord-264884-ydkigome	923	3	studies	study	NNS
cord-264884-ydkigome	923	4	by	by	IN
cord-264884-ydkigome	923	5	Roossinck	Roossinck	NNP
cord-264884-ydkigome	923	6	and	and	CC
cord-264884-ydkigome	923	7	colleagues	colleague	NNS
cord-264884-ydkigome	923	8	(	(	-LRB-
cord-264884-ydkigome	923	9	see	see	VB
cord-264884-ydkigome	923	10	Chapter	chapter	NN
cord-264884-ydkigome	923	11	12	12	CD
cord-264884-ydkigome	923	12	)	)	-RRB-
cord-264884-ydkigome	923	13	,	,	,
cord-264884-ydkigome	923	14	in	in	IN
cord-264884-ydkigome	923	15	which	which	WDT
cord-264884-ydkigome	923	16	a	a	DT
cord-264884-ydkigome	923	17	persisting	persist	VBG
cord-264884-ydkigome	923	18	virus	virus	NN
cord-264884-ydkigome	923	19	,	,	,
cord-264884-ydkigome	923	20	a	a	DT
cord-264884-ydkigome	923	21	plant	plant	NN
cord-264884-ydkigome	923	22	,	,	,
cord-264884-ydkigome	923	23	and	and	CC
cord-264884-ydkigome	923	24	a	a	DT
cord-264884-ydkigome	923	25	fungus	fungus	NN
cord-264884-ydkigome	923	26	were	be	VBD
cord-264884-ydkigome	923	27	all	all	DT
cord-264884-ydkigome	923	28	symbiotically	symbiotically	RB
cord-264884-ydkigome	923	29	involved	involve	VBN
cord-264884-ydkigome	923	30	in	in	IN
cord-264884-ydkigome	923	31	altering	alter	VBG
cord-264884-ydkigome	923	32	the	the	DT
cord-264884-ydkigome	923	33	thermal	thermal	JJ
cord-264884-ydkigome	923	34	tolerance	tolerance	NN
cord-264884-ydkigome	923	35	of	of	IN
cord-264884-ydkigome	923	36	the	the	DT
cord-264884-ydkigome	923	37	plant	plant	NN
cord-264884-ydkigome	923	38	could	could	MD
cord-264884-ydkigome	923	39	be	be	VB
cord-264884-ydkigome	923	40	an	an	DT
cord-264884-ydkigome	923	41	example	example	NN
cord-264884-ydkigome	923	42	of	of	IN
cord-264884-ydkigome	923	43	this	this	DT
cord-264884-ydkigome	923	44	(	(	-LRB-
cord-264884-ydkigome	923	45	Marquez	Marquez	NNP
cord-264884-ydkigome	923	46	et	et	NNP
cord-264884-ydkigome	923	47	al	al	NNP
cord-264884-ydkigome	923	48	.	.	NNP
cord-264884-ydkigome	923	49	,	,	,
cord-264884-ydkigome	923	50	2007	2007	CD
cord-264884-ydkigome	923	51	)	)	-RRB-
cord-264884-ydkigome	923	52	.	.	.
cord-264884-ydkigome	924	1	Many	many	JJ
cord-264884-ydkigome	924	2	other	other	JJ
cord-264884-ydkigome	924	3	virus	virus	NN
cord-264884-ydkigome	924	4	-	-	HYPH
cord-264884-ydkigome	924	5	host	host	NN
cord-264884-ydkigome	924	6	relationships	relationship	NNS
cord-264884-ydkigome	924	7	should	should	MD
cord-264884-ydkigome	924	8	also	also	RB
cord-264884-ydkigome	924	9	be	be	VB
cord-264884-ydkigome	924	10	examined	examine	VBN
cord-264884-ydkigome	924	11	for	for	IN
cord-264884-ydkigome	924	12	possible	possible	JJ
cord-264884-ydkigome	924	13	symbiosis	symbiosis	NN
cord-264884-ydkigome	924	14	.	.	.
cord-264884-ydkigome	925	1	For	for	IN
cord-264884-ydkigome	925	2	example	example	NN
cord-264884-ydkigome	925	3	,	,	,
cord-264884-ydkigome	925	4	placental	placental	JJ
cord-264884-ydkigome	925	5	vertebrate	vertebrate	JJ
cord-264884-ydkigome	925	6	evolution	evolution	NN
cord-264884-ydkigome	925	7	has	have	VBZ
cord-264884-ydkigome	925	8	involved	involve	VBN
cord-264884-ydkigome	925	9	various	various	JJ
cord-264884-ydkigome	925	10	endogenous	endogenous	JJ
cord-264884-ydkigome	925	11	retroviruses	retrovirus	NNS
cord-264884-ydkigome	925	12	(	(	-LRB-
cord-264884-ydkigome	925	13	i.e.	i.e.	FW
cord-264884-ydkigome	925	14	HERV	HERV	NNP
cord-264884-ydkigome	925	15	-	-	HYPH
cord-264884-ydkigome	925	16	W	W	NNP
cord-264884-ydkigome	925	17	,	,	,
cord-264884-ydkigome	925	18	HERV	HERV	NNP
cord-264884-ydkigome	925	19	-	-	HYPH
cord-264884-ydkigome	925	20	FRD	FRD	NNP
cord-264884-ydkigome	925	21	)	)	-RRB-
cord-264884-ydkigome	925	22	.	.	.
cord-264884-ydkigome	926	1	Intact	intact	JJ
cord-264884-ydkigome	926	2	HERV	HERV	NNP
cord-264884-ydkigome	926	3	genomes	genome	NNS
cord-264884-ydkigome	926	4	,	,	,
cord-264884-ydkigome	926	5	including	include	VBG
cord-264884-ydkigome	926	6	env	env	NN
cord-264884-ydkigome	926	7	ORFs	ORFs	NNP
cord-264884-ydkigome	926	8	,	,	,
cord-264884-ydkigome	926	9	are	be	VBP
cord-264884-ydkigome	926	10	important	important	JJ
cord-264884-ydkigome	926	11	for	for	IN
cord-264884-ydkigome	926	12	placental	placental	JJ
cord-264884-ydkigome	926	13	trophoblast	trophoblast	NN
cord-264884-ydkigome	926	14	fusion	fusion	NN
cord-264884-ydkigome	926	15	(	(	-LRB-
cord-264884-ydkigome	926	16	for	for	IN
cord-264884-ydkigome	926	17	references	reference	NNS
cord-264884-ydkigome	926	18	see	see	VBP
cord-264884-ydkigome	926	19	Ryan	Ryan	NNP
cord-264884-ydkigome	926	20	,	,	,
cord-264884-ydkigome	926	21	2007	2007	CD
cord-264884-ydkigome	926	22	)	)	-RRB-
cord-264884-ydkigome	926	23	.	.	.
cord-264884-ydkigome	927	1	Some	some	DT
cord-264884-ydkigome	927	2	will	will	MD
cord-264884-ydkigome	927	3	dismiss	dismiss	VB
cord-264884-ydkigome	927	4	this	this	DT
cord-264884-ydkigome	927	5	situation	situation	NN
cord-264884-ydkigome	927	6	as	as	IN
cord-264884-ydkigome	927	7	the	the	DT
cord-264884-ydkigome	927	8	quirky	quirky	JJ
cord-264884-ydkigome	927	9	usurping	usurping	NN
cord-264884-ydkigome	927	10	of	of	IN
cord-264884-ydkigome	927	11	a	a	DT
cord-264884-ydkigome	927	12	viral	viral	JJ
cord-264884-ydkigome	927	13	gene	gene	NN
cord-264884-ydkigome	927	14	for	for	IN
cord-264884-ydkigome	927	15	host	host	NN
cord-264884-ydkigome	927	16	function	function	NN
cord-264884-ydkigome	927	17	which	which	WDT
cord-264884-ydkigome	927	18	is	be	VBZ
cord-264884-ydkigome	927	19	of	of	IN
cord-264884-ydkigome	927	20	little	little	JJ
cord-264884-ydkigome	927	21	general	general	JJ
cord-264884-ydkigome	927	22	signifi	signifi	NNP
cord-264884-ydkigome	927	23	cance	cance	NN
cord-264884-ydkigome	927	24	.	.	.
cord-264884-ydkigome	928	1	The	the	DT
cord-264884-ydkigome	928	2	specifi	specifi	NN
cord-264884-ydkigome	928	3	c	c	NN
cord-264884-ydkigome	928	4	ERV	ERV	NNP
cord-264884-ydkigome	928	5	involved	involve	VBN
cord-264884-ydkigome	928	6	is	be	VBZ
cord-264884-ydkigome	928	7	simply	simply	RB
cord-264884-ydkigome	928	8	selfi	selfi	JJ
cord-264884-ydkigome	928	9	sh	sh	NNP
cord-264884-ydkigome	928	10	and	and	CC
cord-264884-ydkigome	928	11	mostly	mostly	RB
cord-264884-ydkigome	928	12	defective	defective	JJ
cord-264884-ydkigome	928	13	genetic	genetic	JJ
cord-264884-ydkigome	928	14	material	material	NN
cord-264884-ydkigome	928	15	of	of	IN
cord-264884-ydkigome	928	16	no	no	DT
cord-264884-ydkigome	928	17	general	general	JJ
cord-264884-ydkigome	928	18	consequence	consequence	NN
cord-264884-ydkigome	928	19	.	.	.
cord-264884-ydkigome	929	1	If	if	IN
cord-264884-ydkigome	929	2	so	so	RB
cord-264884-ydkigome	929	3	,	,	,
cord-264884-ydkigome	929	4	why	why	WRB
cord-264884-ydkigome	929	5	is	be	VBZ
cord-264884-ydkigome	929	6	it	-PRON-	PRP
cord-264884-ydkigome	929	7	that	that	IN
cord-264884-ydkigome	929	8	in	in	IN
cord-264884-ydkigome	929	9	sheep	sheep	NN
cord-264884-ydkigome	929	10	a	a	DT
cord-264884-ydkigome	929	11	distinctly	distinctly	RB
cord-264884-ydkigome	929	12	different	different	JJ
cord-264884-ydkigome	929	13	lineage	lineage	NN
cord-264884-ydkigome	929	14	of	of	IN
cord-264884-ydkigome	929	15	retrovirus	retrovirus	NN
cord-264884-ydkigome	929	16	(	(	-LRB-
cord-264884-ydkigome	929	17	enJSRV	enJSRV	NNP
cord-264884-ydkigome	929	18	)	)	-RRB-
cord-264884-ydkigome	929	19	was	be	VBD
cord-264884-ydkigome	929	20	also	also	RB
cord-264884-ydkigome	929	21	selected	select	VBN
cord-264884-ydkigome	929	22	to	to	TO
cord-264884-ydkigome	929	23	provide	provide	VB
cord-264884-ydkigome	929	24	a	a	DT
cord-264884-ydkigome	929	25	related	related	JJ
cord-264884-ydkigome	929	26	placental	placental	NN
cord-264884-ydkigome	929	27	function	function	NN
cord-264884-ydkigome	929	28	to	to	IN
cord-264884-ydkigome	929	29	a	a	DT
cord-264884-ydkigome	929	30	another	another	DT
cord-264884-ydkigome	929	31	mammal	mammal	NN
cord-264884-ydkigome	929	32	with	with	IN
cord-264884-ydkigome	929	33	signifi	signifi	NNP
cord-264884-ydkigome	929	34	cantly	cantly	RB
cord-264884-ydkigome	929	35	different	different	JJ
cord-264884-ydkigome	929	36	placental	placental	JJ
cord-264884-ydkigome	929	37	reproductive	reproductive	JJ
cord-264884-ydkigome	929	38	biology	biology	NN
cord-264884-ydkigome	929	39	?	?	.
cord-264884-ydkigome	930	1	It	-PRON-	PRP
cord-264884-ydkigome	930	2	has	have	VBZ
cord-264884-ydkigome	930	3	been	be	VBN
cord-264884-ydkigome	930	4	experimentally	experimentally	RB
cord-264884-ydkigome	930	5	well	well	RB
cord-264884-ydkigome	930	6	established	establish	VBN
cord-264884-ydkigome	930	7	the	the	DT
cord-264884-ydkigome	930	8	enJSRV	enjsrv	CD
cord-264884-ydkigome	930	9	env	env	NN
cord-264884-ydkigome	930	10	is	be	VBZ
cord-264884-ydkigome	930	11	essential	essential	JJ
cord-264884-ydkigome	930	12	for	for	IN
cord-264884-ydkigome	930	13	sheep	sheep	NN
cord-264884-ydkigome	930	14	embryo	embryo	NN
cord-264884-ydkigome	930	15	implantation	implantation	NN
cord-264884-ydkigome	930	16	(	(	-LRB-
cord-264884-ydkigome	931	1	Dunlap	Dunlap	NNP
cord-264884-ydkigome	931	2	et	et	NNP
cord-264884-ydkigome	931	3	al	al	NNP
cord-264884-ydkigome	931	4	.	.	.
cord-264884-ydkigome	932	1	,	,	,
cord-264884-ydkigome	932	2	2006a	2006a	CD
cord-264884-ydkigome	933	1	(	(	-LRB-
cord-264884-ydkigome	933	2	Dunlap	Dunlap	NNP
cord-264884-ydkigome	933	3	et	et	NNP
cord-264884-ydkigome	933	4	al	al	NNP
cord-264884-ydkigome	933	5	.	.	.
cord-264884-ydkigome	934	1	,	,	,
cord-264884-ydkigome	934	2	,	,	,
cord-264884-ydkigome	934	3	2006b	2006b	CD
cord-264884-ydkigome	934	4	.	.	.
cord-264884-ydkigome	935	1	enJSRV	enJSRV	NNP
cord-264884-ydkigome	935	2	is	be	VBZ
cord-264884-ydkigome	935	3	the	the	DT
cord-264884-ydkigome	935	4	endogenous	endogenous	JJ
cord-264884-ydkigome	935	5	version	version	NN
cord-264884-ydkigome	935	6	of	of	IN
cord-264884-ydkigome	935	7	JSRV	JSRV	NNP
cord-264884-ydkigome	935	8	,	,	,
cord-264884-ydkigome	935	9	a	a	DT
cord-264884-ydkigome	935	10	problematic	problematic	JJ
cord-264884-ydkigome	935	11	sheep	sheep	NN
cord-264884-ydkigome	935	12	-	-	HYPH
cord-264884-ydkigome	935	13	specifi	specifi	NNP
cord-264884-ydkigome	935	14	c	c	NN
cord-264884-ydkigome	935	15	retrovirus	retrovirus	NN
cord-264884-ydkigome	935	16	that	that	WDT
cord-264884-ydkigome	935	17	induces	induce	VBZ
cord-264884-ydkigome	935	18	lung	lung	NN
cord-264884-ydkigome	935	19	tumors	tumor	NNS
cord-264884-ydkigome	935	20	(	(	-LRB-
cord-264884-ydkigome	935	21	responsible	responsible	JJ
cord-264884-ydkigome	935	22	for	for	IN
cord-264884-ydkigome	935	23	the	the	DT
cord-264884-ydkigome	935	24	death	death	NN
cord-264884-ydkigome	935	25	of	of	IN
cord-264884-ydkigome	935	26	Dolly	Dolly	NNP
cord-264884-ydkigome	935	27	,	,	,
cord-264884-ydkigome	935	28	the	the	DT
cord-264884-ydkigome	935	29	famous	famous	JJ
cord-264884-ydkigome	935	30	fi	fi	NN
cord-264884-ydkigome	935	31	rst	rst	NN
cord-264884-ydkigome	935	32	cloned	clone	VBN
cord-264884-ydkigome	935	33	sheep	sheep	NN
cord-264884-ydkigome	935	34	)	)	-RRB-
cord-264884-ydkigome	935	35	.	.	.
cord-264884-ydkigome	936	1	The	the	DT
cord-264884-ydkigome	936	2	endogenous	endogenous	JJ
cord-264884-ydkigome	936	3	virus	virus	NN
cord-264884-ydkigome	936	4	(	(	-LRB-
cord-264884-ydkigome	936	5	enJSRV	enJSRV	NNP
cord-264884-ydkigome	936	6	)	)	-RRB-
cord-264884-ydkigome	936	7	is	be	VBZ
cord-264884-ydkigome	936	8	present	present	JJ
cord-264884-ydkigome	936	9	in	in	IN
cord-264884-ydkigome	936	10	20	20	CD
cord-264884-ydkigome	936	11	copies	copy	NNS
cord-264884-ydkigome	936	12	in	in	IN
cord-264884-ydkigome	936	13	the	the	DT
cord-264884-ydkigome	936	14	sheep	sheep	NN
cord-264884-ydkigome	936	15	genome	genome	NN
cord-264884-ydkigome	936	16	and	and	CC
cord-264884-ydkigome	936	17	all	all	DT
cord-264884-ydkigome	936	18	sheep	sheep	NNS
cord-264884-ydkigome	936	19	have	have	VBP
cord-264884-ydkigome	936	20	this	this	DT
cord-264884-ydkigome	936	21	virus	virus	NN
cord-264884-ydkigome	936	22	.	.	.
cord-264884-ydkigome	937	1	Sheep	sheep	NN
cord-264884-ydkigome	937	2	genomes	genome	NNS
cord-264884-ydkigome	937	3	also	also	RB
cord-264884-ydkigome	937	4	encoded	encode	VBD
cord-264884-ydkigome	937	5	a	a	DT
cord-264884-ydkigome	937	6	trans	trans	JJ
cord-264884-ydkigome	937	7	-dominant	-dominant	JJ
cord-264884-ydkigome	937	8	enJRSV	enJRSV	NNP
cord-264884-ydkigome	937	9	gag	gag	NN
cord-264884-ydkigome	937	10	that	that	WDT
cord-264884-ydkigome	937	11	is	be	VBZ
cord-264884-ydkigome	937	12	inhibitory	inhibitory	JJ
cord-264884-ydkigome	937	13	to	to	IN
cord-264884-ydkigome	937	14	exogenous	exogenous	JJ
cord-264884-ydkigome	937	15	JSRV	JSRV	NNP
cord-264884-ydkigome	937	16	(	(	-LRB-
cord-264884-ydkigome	938	1	Mura	Mura	NNP
cord-264884-ydkigome	938	2	et	et	NNP
cord-264884-ydkigome	938	3	al	al	NNP
cord-264884-ydkigome	938	4	.	.	.
cord-264884-ydkigome	939	1	,	,	,
cord-264884-ydkigome	939	2	2004	2004	CD
cord-264884-ydkigome	939	3	;	;	:
cord-264884-ydkigome	939	4	Oliveira	Oliveira	NNP
cord-264884-ydkigome	939	5	et	et	NNP
cord-264884-ydkigome	939	6	al	al	NNP
cord-264884-ydkigome	939	7	.	.	NNP
cord-264884-ydkigome	939	8	,	,	,
cord-264884-ydkigome	939	9	2006	2006	CD
cord-264884-ydkigome	939	10	;	;	:
cord-264884-ydkigome	939	11	Murcia	Murcia	NNP
cord-264884-ydkigome	939	12	et	et	NNP
cord-264884-ydkigome	939	13	al	al	NNP
cord-264884-ydkigome	939	14	.	.	NNP
cord-264884-ydkigome	939	15	,	,	,
cord-264884-ydkigome	939	16	2007	2007	CD
cord-264884-ydkigome	939	17	)	)	-RRB-
cord-264884-ydkigome	939	18	.	.	.
cord-264884-ydkigome	940	1	It	-PRON-	PRP
cord-264884-ydkigome	940	2	seems	seem	VBZ
cord-264884-ydkigome	940	3	clear	clear	JJ
cord-264884-ydkigome	940	4	that	that	IN
cord-264884-ydkigome	940	5	this	this	DT
cord-264884-ydkigome	940	6	situation	situation	NN
cord-264884-ydkigome	940	7	can	can	MD
cord-264884-ydkigome	940	8	also	also	RB
cord-264884-ydkigome	940	9	be	be	VB
cord-264884-ydkigome	940	10	considered	consider	VBN
cord-264884-ydkigome	940	11	from	from	IN
cord-264884-ydkigome	940	12	the	the	DT
cord-264884-ydkigome	940	13	perspective	perspective	NN
cord-264884-ydkigome	940	14	of	of	IN
cord-264884-ydkigome	940	15	viral	viral	JJ
cord-264884-ydkigome	940	16	symbiosis	symbiosis	NN
cord-264884-ydkigome	940	17	and/or	and/or	CC
cord-264884-ydkigome	940	18	virus	virus	NN
cord-264884-ydkigome	940	19	addiction	addiction	NN
cord-264884-ydkigome	940	20	in	in	IN
cord-264884-ydkigome	940	21	host	host	NN
cord-264884-ydkigome	940	22	evolution	evolution	NN
cord-264884-ydkigome	940	23	.	.	.
cord-264884-ydkigome	941	1	We	-PRON-	PRP
cord-264884-ydkigome	941	2	should	should	MD
cord-264884-ydkigome	941	3	thus	thus	RB
cord-264884-ydkigome	941	4	seek	seek	VB
cord-264884-ydkigome	941	5	to	to	TO
cord-264884-ydkigome	941	6	understand	understand	VB
cord-264884-ydkigome	941	7	why	why	WRB
cord-264884-ydkigome	941	8	colonization	colonization	NN
cord-264884-ydkigome	941	9	by	by	IN
cord-264884-ydkigome	941	10	an	an	DT
cord-264884-ydkigome	941	11	ERV	ERV	NNP
cord-264884-ydkigome	941	12	population	population	NN
cord-264884-ydkigome	941	13	might	may	MD
cord-264884-ydkigome	941	14	generally	generally	RB
cord-264884-ydkigome	941	15	provide	provide	VB
cord-264884-ydkigome	941	16	a	a	DT
cord-264884-ydkigome	941	17	good	good	JJ
cord-264884-ydkigome	941	18	solution	solution	NN
cord-264884-ydkigome	941	19	to	to	IN
cord-264884-ydkigome	941	20	the	the	DT
cord-264884-ydkigome	941	21	evolutionary	evolutionary	JJ
cord-264884-ydkigome	941	22	demands	demand	NNS
cord-264884-ydkigome	941	23	of	of	IN
cord-264884-ydkigome	941	24	placental	placental	JJ
cord-264884-ydkigome	941	25	biology	biology	NN
cord-264884-ydkigome	941	26	.	.	.
cord-264884-ydkigome	942	1	There	there	EX
cord-264884-ydkigome	942	2	are	be	VBP
cord-264884-ydkigome	942	3	many	many	JJ
cord-264884-ydkigome	942	4	other	other	JJ
cord-264884-ydkigome	942	5	opportunities	opportunity	NNS
cord-264884-ydkigome	942	6	to	to	TO
cord-264884-ydkigome	942	7	examine	examine	VB
cord-264884-ydkigome	942	8	the	the	DT
cord-264884-ydkigome	942	9	potential	potential	JJ
cord-264884-ydkigome	942	10	role	role	NN
cord-264884-ydkigome	942	11	of	of	IN
cord-264884-ydkigome	942	12	persistent	persistent	JJ
cord-264884-ydkigome	942	13	and	and	CC
cord-264884-ydkigome	942	14	symbiotic	symbiotic	JJ
cord-264884-ydkigome	942	15	viruses	virus	NNS
cord-264884-ydkigome	942	16	in	in	IN
cord-264884-ydkigome	942	17	the	the	DT
cord-264884-ydkigome	942	18	evolution	evolution	NN
cord-264884-ydkigome	942	19	of	of	IN
cord-264884-ydkigome	942	20	viruses	virus	NNS
cord-264884-ydkigome	942	21	,	,	,
cord-264884-ydkigome	942	22	animals	animal	NNS
cord-264884-ydkigome	942	23	,	,	,
cord-264884-ydkigome	942	24	primates	primate	NNS
cord-264884-ydkigome	942	25	,	,	,
cord-264884-ydkigome	942	26	and	and	CC
cord-264884-ydkigome	942	27	humans	human	NNS
cord-264884-ydkigome	942	28	.	.	.
cord-264884-ydkigome	943	1	For	for	IN
cord-264884-ydkigome	943	2	example	example	NN
cord-264884-ydkigome	943	3	,	,	,
cord-264884-ydkigome	943	4	as	as	IN
cord-264884-ydkigome	943	5	we	-PRON-	PRP
cord-264884-ydkigome	943	6	seek	seek	VBP
cord-264884-ydkigome	943	7	to	to	TO
cord-264884-ydkigome	943	8	understand	understand	VB
cord-264884-ydkigome	943	9	the	the	DT
cord-264884-ydkigome	943	10	origins	origin	NNS
cord-264884-ydkigome	943	11	of	of	IN
cord-264884-ydkigome	943	12	the	the	DT
cord-264884-ydkigome	943	13	adaptive	adaptive	JJ
cord-264884-ydkigome	943	14	immune	immune	JJ
cord-264884-ydkigome	943	15	system	system	NN
cord-264884-ydkigome	943	16	we	-PRON-	PRP
cord-264884-ydkigome	943	17	should	should	MD
cord-264884-ydkigome	943	18	pay	pay	VB
cord-264884-ydkigome	943	19	attention	attention	NN
cord-264884-ydkigome	943	20	to	to	IN
cord-264884-ydkigome	943	21	viral	viral	JJ
cord-264884-ydkigome	943	22	footprints	footprint	NNS
cord-264884-ydkigome	943	23	.	.	.
cord-264884-ydkigome	944	1	We	-PRON-	PRP
cord-264884-ydkigome	944	2	can	can	MD
cord-264884-ydkigome	944	3	ask	ask	VB
cord-264884-ydkigome	944	4	,	,	,
cord-264884-ydkigome	944	5	for	for	IN
cord-264884-ydkigome	944	6	example	example	NN
cord-264884-ydkigome	944	7	,	,	,
cord-264884-ydkigome	944	8	why	why	WRB
cord-264884-ydkigome	944	9	the	the	DT
cord-264884-ydkigome	944	10	major	major	JJ
cord-264884-ydkigome	944	11	histocompatibility	histocompatibility	NN
cord-264884-ydkigome	944	12	complex	complex	NN
cord-264884-ydkigome	944	13	(	(	-LRB-
cord-264884-ydkigome	944	14	MHC	MHC	NNP
cord-264884-ydkigome	944	15	)	)	-RRB-
cord-264884-ydkigome	944	16	locus	locus	NN
cord-264884-ydkigome	944	17	,	,	,
cord-264884-ydkigome	944	18	the	the	DT
cord-264884-ydkigome	944	19	most	most	RBS
cord-264884-ydkigome	944	20	polymorphic	polymorphic	JJ
cord-264884-ydkigome	944	21	,	,	,
cord-264884-ydkigome	944	22	diverse	diverse	JJ
cord-264884-ydkigome	944	23	,	,	,
cord-264884-ydkigome	944	24	and	and	CC
cord-264884-ydkigome	944	25	rapidly	rapidly	RB
cord-264884-ydkigome	944	26	evolving	evolve	VBG
cord-264884-ydkigome	944	27	gene	gene	NN
cord-264884-ydkigome	944	28	set	set	VBN
cord-264884-ydkigome	944	29	in	in	IN
cord-264884-ydkigome	944	30	our	-PRON-	PRP$
cord-264884-ydkigome	944	31	chromosome	chromosome	NN
cord-264884-ydkigome	944	32	,	,	,
cord-264884-ydkigome	944	33	is	be	VBZ
cord-264884-ydkigome	944	34	so	so	RB
cord-264884-ydkigome	944	35	densely	densely	RB
cord-264884-ydkigome	944	36	colonized	colonize	VBN
cord-264884-ydkigome	944	37	with	with	IN
cord-264884-ydkigome	944	38	retroviral	retroviral	JJ
cord-264884-ydkigome	944	39	elements	element	NNS
cord-264884-ydkigome	944	40	(	(	-LRB-
cord-264884-ydkigome	944	41	Andersson	Andersson	NNP
cord-264884-ydkigome	944	42	et	et	NNP
cord-264884-ydkigome	944	43	al	al	NNP
cord-264884-ydkigome	944	44	.	.	NNP
cord-264884-ydkigome	944	45	,	,	,
cord-264884-ydkigome	944	46	1998	1998	CD
cord-264884-ydkigome	944	47	)	)	-RRB-
cord-264884-ydkigome	944	48	.	.	.
cord-264884-ydkigome	945	1	Why	why	WRB
cord-264884-ydkigome	945	2	is	be	VBZ
cord-264884-ydkigome	945	3	a	a	DT
cord-264884-ydkigome	945	4	retrovirus	retrovirus	NN
cord-264884-ydkigome	945	5	also	also	RB
cord-264884-ydkigome	945	6	the	the	DT
cord-264884-ydkigome	945	7	basic	basic	JJ
cord-264884-ydkigome	945	8	element	element	NN
cord-264884-ydkigome	945	9	of	of	IN
cord-264884-ydkigome	945	10	the	the	DT
cord-264884-ydkigome	945	11	duplication	duplication	NN
cord-264884-ydkigome	945	12	unit	unit	NN
cord-264884-ydkigome	945	13	that	that	WDT
cord-264884-ydkigome	945	14	was	be	VBD
cord-264884-ydkigome	945	15	thought	think	VBN
cord-264884-ydkigome	945	16	to	to	TO
cord-264884-ydkigome	945	17	have	have	VB
cord-264884-ydkigome	945	18	been	be	VBN
cord-264884-ydkigome	945	19	the	the	DT
cord-264884-ydkigome	945	20	progenitor	progenitor	NN
cord-264884-ydkigome	945	21	for	for	IN
cord-264884-ydkigome	945	22	the	the	DT
cord-264884-ydkigome	945	23	expansion	expansion	NN
cord-264884-ydkigome	945	24	of	of	IN
cord-264884-ydkigome	945	25	the	the	DT
cord-264884-ydkigome	945	26	MHC	MHC	NNP
cord-264884-ydkigome	945	27	class	class	NN
cord-264884-ydkigome	945	28	I	i	NN
cord-264884-ydkigome	945	29	(	(	-LRB-
cord-264884-ydkigome	945	30	and	and	CC
cord-264884-ydkigome	945	31	II	II	NNP
cord-264884-ydkigome	945	32	)	)	-RRB-
cord-264884-ydkigome	945	33	genes	gene	NNS
cord-264884-ydkigome	945	34	(	(	-LRB-
cord-264884-ydkigome	945	35	Gaudieri	Gaudieri	NNP
cord-264884-ydkigome	945	36	et	et	NNP
cord-264884-ydkigome	945	37	al	al	NNP
cord-264884-ydkigome	945	38	.	.	NNP
cord-264884-ydkigome	945	39	,	,	,
cord-264884-ydkigome	945	40	1997	1997	CD
cord-264884-ydkigome	945	41	;	;	:
cord-264884-ydkigome	945	42	Kulski	Kulski	NNP
cord-264884-ydkigome	945	43	et	et	IN
cord-264884-ydkigome	945	44	al	al	NNP
cord-264884-ydkigome	945	45	.	.	NNP
cord-264884-ydkigome	945	46	,	,	,
cord-264884-ydkigome	945	47	1998	1998	CD
cord-264884-ydkigome	946	1	Kulski	Kulski	NNP
cord-264884-ydkigome	946	2	et	et	IN
cord-264884-ydkigome	946	3	al	al	NNP
cord-264884-ydkigome	946	4	.	.	.
cord-264884-ydkigome	947	1	,	,	,
cord-264884-ydkigome	947	2	,	,	,
cord-264884-ydkigome	947	3	2005	2005	CD
cord-264884-ydkigome	947	4	?	?	.
cord-264884-ydkigome	948	1	Why	why	WRB
cord-264884-ydkigome	948	2	do	do	VBP
cord-264884-ydkigome	948	3	similar	similar	JJ
cord-264884-ydkigome	948	4	HERV	HERV	NNP
cord-264884-ydkigome	948	5	element	element	NN
cord-264884-ydkigome	948	6	(	(	-LRB-
cord-264884-ydkigome	948	7	L	l	NN
cord-264884-ydkigome	948	8	and	and	CC
cord-264884-ydkigome	948	9	16	16	CD
cord-264884-ydkigome	948	10	)	)	-RRB-
cord-264884-ydkigome	948	11	also	also	RB
cord-264884-ydkigome	948	12	differentiate	differentiate	VBP
cord-264884-ydkigome	948	13	between	between	IN
cord-264884-ydkigome	949	1	human	human	JJ
cord-264884-ydkigome	949	2	and	and	CC
cord-264884-ydkigome	949	3	chimpanzee	chimpanzee	NN
cord-264884-ydkigome	949	4	MHC	MHC	NNP
cord-264884-ydkigome	949	5	I	I	NNP
cord-264884-ydkigome	949	6	(	(	-LRB-
cord-264884-ydkigome	949	7	Watkins	Watkins	NNP
cord-264884-ydkigome	949	8	,	,	,
cord-264884-ydkigome	949	9	1995	1995	CD
cord-264884-ydkigome	949	10	;	;	:
cord-264884-ydkigome	949	11	Kulski	Kulski	NNP
cord-264884-ydkigome	949	12	et	et	IN
cord-264884-ydkigome	949	13	al	al	NNP
cord-264884-ydkigome	949	14	.	.	NNP
cord-264884-ydkigome	949	15	,	,	,
cord-264884-ydkigome	949	16	1999	1999	CD
cord-264884-ydkigome	949	17	)	)	-RRB-
cord-264884-ydkigome	949	18	?	?	.
cord-264884-ydkigome	950	1	What	what	WP
cord-264884-ydkigome	950	2	was	be	VBD
cord-264884-ydkigome	950	3	the	the	DT
cord-264884-ydkigome	950	4	role	role	NN
cord-264884-ydkigome	950	5	for	for	IN
cord-264884-ydkigome	950	6	SIV	SIV	NNP
cord-264884-ydkigome	950	7	in	in	IN
cord-264884-ydkigome	950	8	the	the	DT
cord-264884-ydkigome	950	9	evolution	evolution	NN
cord-264884-ydkigome	950	10	of	of	IN
cord-264884-ydkigome	950	11	primate	primate	NN
cord-264884-ydkigome	950	12	MHC	MHC	NNP
cord-264884-ydkigome	950	13	(	(	-LRB-
cord-264884-ydkigome	950	14	Vogel	Vogel	NNP
cord-264884-ydkigome	950	15	et	et	NNP
cord-264884-ydkigome	950	16	al	al	NNP
cord-264884-ydkigome	950	17	.	.	NNP
cord-264884-ydkigome	950	18	,	,	,
cord-264884-ydkigome	950	19	1999	1999	CD
cord-264884-ydkigome	950	20	)	)	-RRB-
cord-264884-ydkigome	950	21	?	?	.
cord-264884-ydkigome	951	1	Humans	human	NNS
cord-264884-ydkigome	951	2	and	and	CC
cord-264884-ydkigome	951	3	primates	primate	NNS
cord-264884-ydkigome	951	4	appear	appear	VBP
cord-264884-ydkigome	951	5	to	to	TO
cord-264884-ydkigome	951	6	have	have	VB
cord-264884-ydkigome	951	7	undergone	undergo	VBN
cord-264884-ydkigome	951	8	some	some	DT
cord-264884-ydkigome	951	9	signifi	signifi	NNP
cord-264884-ydkigome	951	10	ca	can	MD
cord-264884-ydkigome	951	11	nt	not	RB
cord-264884-ydkigome	951	12	and	and	CC
cord-264884-ydkigome	951	13	relatively	relatively	RB
cord-264884-ydkigome	951	14	recent	recent	JJ
cord-264884-ydkigome	951	15	evolution	evolution	NN
cord-264884-ydkigome	951	16	with	with	IN
cord-264884-ydkigome	951	17	regard	regard	NN
cord-264884-ydkigome	951	18	to	to	IN
cord-264884-ydkigome	951	19	their	-PRON-	PRP$
cord-264884-ydkigome	951	20	endogenous	endogenous	JJ
cord-264884-ydkigome	951	21	and	and	CC
cord-264884-ydkigome	951	22	exogeneous	exogeneous	JJ
cord-264884-ydkigome	951	23	retroviruses	retrovirus	NNS
cord-264884-ydkigome	951	24	.	.	.
cord-264884-ydkigome	952	1	Along	along	IN
cord-264884-ydkigome	952	2	these	these	DT
cord-264884-ydkigome	952	3	lines	line	NNS
cord-264884-ydkigome	952	4	,	,	,
cord-264884-ydkigome	952	5	APOBEC	APOBEC	NNP
cord-264884-ydkigome	952	6	-	-	HYPH
cord-264884-ydkigome	952	7	like	like	JJ
cord-264884-ydkigome	952	8	genes	gene	NNS
cord-264884-ydkigome	952	9	are	be	VBP
cord-264884-ydkigome	952	10	basic	basic	JJ
cord-264884-ydkigome	952	11	component	component	NN
cord-264884-ydkigome	952	12	of	of	IN
cord-264884-ydkigome	952	13	the	the	DT
cord-264884-ydkigome	952	14	adaptive	adaptive	JJ
cord-264884-ydkigome	952	15	immune	immune	JJ
cord-264884-ydkigome	952	16	response	response	NN
cord-264884-ydkigome	952	17	but	but	CC
cord-264884-ydkigome	952	18	they	-PRON-	PRP
cord-264884-ydkigome	952	19	are	be	VBP
cord-264884-ydkigome	952	20	also	also	RB
cord-264884-ydkigome	952	21	antiretroviral	antiretroviral	JJ
cord-264884-ydkigome	952	22	genes	gene	NNS
cord-264884-ydkigome	952	23	that	that	WDT
cord-264884-ydkigome	952	24	act	act	VBP
cord-264884-ydkigome	952	25	on	on	IN
cord-264884-ydkigome	952	26	retroviral	retroviral	NNP
cord-264884-ydkigome	952	27	cDNA	cdna	NN
cord-264884-ydkigome	952	28	and	and	CC
cord-264884-ydkigome	952	29	gag	gag	NN
cord-264884-ydkigome	952	30	(	(	-LRB-
cord-264884-ydkigome	952	31	OhAinle	OhAinle	NNP
cord-264884-ydkigome	952	32	et	et	NNP
cord-264884-ydkigome	952	33	al	al	NNP
cord-264884-ydkigome	952	34	.	.	NNP
cord-264884-ydkigome	952	35	,	,	,
cord-264884-ydkigome	952	36	2006	2006	CD
cord-264884-ydkigome	952	37	)	)	-RRB-
cord-264884-ydkigome	952	38	.	.	.
cord-264884-ydkigome	953	1	The	the	DT
cord-264884-ydkigome	953	2	APOBEC3	apobec3	DT
cord-264884-ydkigome	953	3	antiviral	antiviral	JJ
cord-264884-ydkigome	953	4	system	system	NN
cord-264884-ydkigome	953	5	has	have	VBZ
cord-264884-ydkigome	953	6	expanded	expand	VBN
cord-264884-ydkigome	953	7	recently	recently	RB
cord-264884-ydkigome	953	8	in	in	IN
cord-264884-ydkigome	953	9	humans	human	NNS
cord-264884-ydkigome	953	10	,	,	,
cord-264884-ydkigome	953	11	but	but	CC
cord-264884-ydkigome	953	12	not	not	RB
cord-264884-ydkigome	953	13	chimpanzees	chimpanzee	NNS
cord-264884-ydkigome	953	14	(	(	-LRB-
cord-264884-ydkigome	953	15	Sawyer	Sawyer	NNP
cord-264884-ydkigome	953	16	et	et	NNP
cord-264884-ydkigome	953	17	al	al	NNP
cord-264884-ydkigome	953	18	.	.	NNP
cord-264884-ydkigome	953	19	,	,	,
cord-264884-ydkigome	953	20	2004	2004	CD
cord-264884-ydkigome	953	21	;	;	:
cord-264884-ydkigome	953	22	OhAinle	OhAinle	NNP
cord-264884-ydkigome	953	23	et	et	NNP
cord-264884-ydkigome	953	24	al	al	NNP
cord-264884-ydkigome	953	25	.	.	NNP
cord-264884-ydkigome	953	26	,	,	,
cord-264884-ydkigome	953	27	2006	2006	CD
cord-264884-ydkigome	953	28	)	)	-RRB-
cord-264884-ydkigome	953	29	.	.	.
cord-264884-ydkigome	954	1	Why	why	WRB
cord-264884-ydkigome	954	2	?	?	.
cord-264884-ydkigome	955	1	All	all	DT
cord-264884-ydkigome	955	2	African	african	JJ
cord-264884-ydkigome	955	3	primates	primate	NNS
cord-264884-ydkigome	955	4	support	support	VBP
cord-264884-ydkigome	955	5	unapparent	unapparent	JJ
cord-264884-ydkigome	955	6	foamy	foamy	NN
cord-264884-ydkigome	955	7	viruses	virus	NNS
cord-264884-ydkigome	955	8	(	(	-LRB-
cord-264884-ydkigome	955	9	and	and	CC
cord-264884-ydkigome	955	10	also	also	RB
cord-264884-ydkigome	955	11	SIV	SIV	NNP
cord-264884-ydkigome	955	12	co	co	NN
cord-264884-ydkigome	955	13	-	-	NN
cord-264884-ydkigome	955	14	infection	infection	NN
cord-264884-ydkigome	955	15	)	)	-RRB-
cord-264884-ydkigome	955	16	,	,	,
cord-264884-ydkigome	955	17	but	but	CC
cord-264884-ydkigome	955	18	not	not	RB
cord-264884-ydkigome	955	19	humans	human	NNS
cord-264884-ydkigome	955	20	(	(	-LRB-
cord-264884-ydkigome	955	21	Murray	Murray	NNP
cord-264884-ydkigome	955	22	and	and	CC
cord-264884-ydkigome	955	23	Linial	Linial	NNP
cord-264884-ydkigome	955	24	,	,	,
cord-264884-ydkigome	955	25	2006	2006	CD
cord-264884-ydkigome	955	26	)	)	-RRB-
cord-264884-ydkigome	955	27	.	.	.
cord-264884-ydkigome	956	1	APOBEC3C	APOBEC3C	NNP
cord-264884-ydkigome	956	2	is	be	VBZ
cord-264884-ydkigome	956	3	active	active	JJ
cord-264884-ydkigome	956	4	against	against	IN
cord-264884-ydkigome	956	5	foamy	foamy	JJ
cord-264884-ydkigome	956	6	viruses	virus	NNS
cord-264884-ydkigome	957	1	(	(	-LRB-
cord-264884-ydkigome	957	2	Delebecque	Delebecque	NNP
cord-264884-ydkigome	957	3	et	et	FW
cord-264884-ydkigome	957	4	al	al	NNP
cord-264884-ydkigome	957	5	.	.	NNP
cord-264884-ydkigome	957	6	,	,	,
cord-264884-ydkigome	957	7	2006	2006	CD
cord-264884-ydkigome	957	8	)	)	-RRB-
cord-264884-ydkigome	957	9	.	.	.
cord-264884-ydkigome	958	1	Old	old	JJ
cord-264884-ydkigome	958	2	World	World	NNP
cord-264884-ydkigome	958	3	primates	primate	NNS
cord-264884-ydkigome	958	4	also	also	RB
cord-264884-ydkigome	958	5	underwent	undergo	VBD
cord-264884-ydkigome	958	6	an	an	DT
cord-264884-ydkigome	958	7	expansion	expansion	NN
cord-264884-ydkigome	958	8	of	of	IN
cord-264884-ydkigome	958	9	ERVL	ERVL	NNP
cord-264884-ydkigome	958	10	colonization	colonization	NN
cord-264884-ydkigome	958	11	(	(	-LRB-
cord-264884-ydkigome	958	12	a	a	DT
cord-264884-ydkigome	958	13	clear	clear	JJ
cord-264884-ydkigome	958	14	relative	relative	NN
cord-264884-ydkigome	958	15	of	of	IN
cord-264884-ydkigome	958	16	foamy	foamy	JJ
cord-264884-ydkigome	958	17	virus	virus	NN
cord-264884-ydkigome	958	18	)	)	-RRB-
cord-264884-ydkigome	959	1	(	(	-LRB-
cord-264884-ydkigome	959	2	Sawyer	Sawyer	NNP
cord-264884-ydkigome	959	3	et	et	NNP
cord-264884-ydkigome	959	4	al	al	NNP
cord-264884-ydkigome	959	5	.	.	NNP
cord-264884-ydkigome	959	6	,	,	,
cord-264884-ydkigome	959	7	2004	2004	CD
cord-264884-ydkigome	959	8	)	)	-RRB-
cord-264884-ydkigome	959	9	.	.	.
cord-264884-ydkigome	960	1	Was	be	VBD
cord-264884-ydkigome	960	2	this	this	DT
cord-264884-ydkigome	960	3	ERVL	ERVL	NNP
cord-264884-ydkigome	960	4	colonization	colonization	NN
cord-264884-ydkigome	960	5	of	of	IN
cord-264884-ydkigome	960	6	relevance	relevance	NN
cord-264884-ydkigome	960	7	to	to	IN
cord-264884-ydkigome	960	8	the	the	DT
cord-264884-ydkigome	960	9	ancient	ancient	JJ
cord-264884-ydkigome	960	10	co	co	NN
cord-264884-ydkigome	960	11	-	-	NN
cord-264884-ydkigome	960	12	speciation	speciation	NN
cord-264884-ydkigome	960	13	of	of	IN
cord-264884-ydkigome	960	14	simian	simian	JJ
cord-264884-ydkigome	960	15	foamy	foamy	NN
cord-264884-ydkigome	960	16	virus	virus	NN
cord-264884-ydkigome	960	17	and	and	CC
cord-264884-ydkigome	960	18	their	-PRON-	PRP$
cord-264884-ydkigome	960	19	primate	primate	JJ
cord-264884-ydkigome	960	20	host	host	NN
cord-264884-ydkigome	960	21	(	(	-LRB-
cord-264884-ydkigome	960	22	Switzer	Switzer	NNP
cord-264884-ydkigome	960	23	et	et	NNP
cord-264884-ydkigome	960	24	al	al	NNP
cord-264884-ydkigome	960	25	.	.	NNP
cord-264884-ydkigome	960	26	,	,	,
cord-264884-ydkigome	960	27	2005	2005	CD
cord-264884-ydkigome	960	28	)	)	-RRB-
cord-264884-ydkigome	960	29	?	?	.
cord-264884-ydkigome	961	1	What	what	WP
cord-264884-ydkigome	961	2	exactly	exactly	RB
cord-264884-ydkigome	961	3	was	be	VBD
cord-264884-ydkigome	961	4	the	the	DT
cord-264884-ydkigome	961	5	relevance	relevance	NN
cord-264884-ydkigome	961	6	of	of	IN
cord-264884-ydkigome	961	7	HERV	HERV	NNP
cord-264884-ydkigome	961	8	endogenization	endogenization	NN
cord-264884-ydkigome	961	9	to	to	IN
cord-264884-ydkigome	961	10	human	human	JJ
cord-264884-ydkigome	961	11	survival	survival	NN
cord-264884-ydkigome	961	12	and	and	CC
cord-264884-ydkigome	961	13	adaptations	adaptation	NNS
cord-264884-ydkigome	961	14	?	?	.
cord-264884-ydkigome	962	1	Curiously	curiously	RB
cord-264884-ydkigome	962	2	,	,	,
cord-264884-ydkigome	962	3	human	human	JJ
cord-264884-ydkigome	962	4	brain	brain	NN
cord-264884-ydkigome	962	5	(	(	-LRB-
cord-264884-ydkigome	962	6	neocortex	neocortex	NNP
cord-264884-ydkigome	962	7	)	)	-RRB-
cord-264884-ydkigome	962	8	specifically	specifically	RB
cord-264884-ydkigome	962	9	expresses	express	VBZ
cord-264884-ydkigome	962	10	many	many	JJ
cord-264884-ydkigome	962	11	of	of	IN
cord-264884-ydkigome	962	12	these	these	DT
cord-264884-ydkigome	962	13	more	more	JJR
cord-264884-ydkigome	962	14	recent	recent	JJ
cord-264884-ydkigome	962	15	ERVs	erv	NNS
cord-264884-ydkigome	962	16	as	as	IN
cord-264884-ydkigome	962	17	transcripts	transcript	NNS
cord-264884-ydkigome	963	1	(	(	-LRB-
cord-264884-ydkigome	963	2	Nakamura	Nakamura	NNP
cord-264884-ydkigome	963	3	et	et	NNP
cord-264884-ydkigome	963	4	al	al	NNP
cord-264884-ydkigome	963	5	.	.	NNP
cord-264884-ydkigome	963	6	,	,	,
cord-264884-ydkigome	963	7	2003	2003	CD
cord-264884-ydkigome	964	1	;	;	:
cord-264884-ydkigome	964	2	Yi	Yi	NNP
cord-264884-ydkigome	964	3	et	et	FW
cord-264884-ydkigome	964	4	al	al	NNP
cord-264884-ydkigome	964	5	.	.	NNP
cord-264884-ydkigome	964	6	,	,	,
cord-264884-ydkigome	964	7	2004	2004	CD
cord-264884-ydkigome	964	8	)	)	-RRB-
cord-264884-ydkigome	964	9	.	.	.
cord-264884-ydkigome	965	1	If	if	IN
cord-264884-ydkigome	965	2	we	-PRON-	PRP
cord-264884-ydkigome	965	3	consider	consider	VBP
cord-264884-ydkigome	965	4	these	these	DT
cord-264884-ydkigome	965	5	situations	situation	NNS
cord-264884-ydkigome	965	6	as	as	IN
cord-264884-ydkigome	965	7	possible	possible	JJ
cord-264884-ydkigome	965	8	examples	example	NNS
cord-264884-ydkigome	965	9	of	of	IN
cord-264884-ydkigome	965	10	virus	virus	NN
cord-264884-ydkigome	965	11	-	-	HYPH
cord-264884-ydkigome	965	12	mediated	mediate	VBN
cord-264884-ydkigome	965	13	symbiosis	symbiosis	NN
cord-264884-ydkigome	965	14	in	in	IN
cord-264884-ydkigome	965	15	human	human	JJ
cord-264884-ydkigome	965	16	evolution	evolution	NN
cord-264884-ydkigome	965	17	,	,	,
cord-264884-ydkigome	965	18	perhaps	perhaps	RB
cord-264884-ydkigome	965	19	they	-PRON-	PRP
cord-264884-ydkigome	965	20	may	may	MD
cord-264884-ydkigome	965	21	make	make	VB
cord-264884-ydkigome	965	22	more	more	JJR
cord-264884-ydkigome	965	23	sense	sense	NN
cord-264884-ydkigome	965	24	of	of	IN
cord-264884-ydkigome	965	25	the	the	DT
cord-264884-ydkigome	965	26	otherwise	otherwise	RB
cord-264884-ydkigome	965	27	confusing	confusing	JJ
cord-264884-ydkigome	965	28	role	role	NN
cord-264884-ydkigome	965	29	or	or	CC
cord-264884-ydkigome	965	30	HERVs	herv	NNS
cord-264884-ydkigome	965	31	.	.	.
cord-264884-ydkigome	966	1	As	as	IN
cord-264884-ydkigome	966	2	noted	note	VBN
cord-264884-ydkigome	966	3	,	,	,
cord-264884-ydkigome	966	4	all	all	DT
cord-264884-ydkigome	966	5	primates	primate	NNS
cord-264884-ydkigome	966	6	,	,	,
cord-264884-ydkigome	966	7	but	but	CC
cord-264884-ydkigome	966	8	especially	especially	RB
cord-264884-ydkigome	966	9	humans	human	NNS
cord-264884-ydkigome	966	10	show	show	VBP
cord-264884-ydkigome	966	11	much	much	JJ
cord-264884-ydkigome	966	12	evidence	evidence	NN
cord-264884-ydkigome	966	13	of	of	IN
cord-264884-ydkigome	966	14	recent	recent	JJ
cord-264884-ydkigome	966	15	endogenization	endogenization	NN
cord-264884-ydkigome	966	16	by	by	IN
cord-264884-ydkigome	966	17	retroviruses	retrovirus	NNS
cord-264884-ydkigome	966	18	.	.	.
cord-264884-ydkigome	967	1	But	but	CC
cord-264884-ydkigome	967	2	these	these	DT
cord-264884-ydkigome	967	3	events	event	NNS
cord-264884-ydkigome	967	4	mostly	mostly	RB
cord-264884-ydkigome	967	5	occurred	occur	VBD
cord-264884-ydkigome	967	6	in	in	IN
cord-264884-ydkigome	967	7	our	-PRON-	PRP$
cord-264884-ydkigome	967	8	extinct	extinct	JJ
cord-264884-ydkigome	967	9	ancestors	ancestor	NNS
cord-264884-ydkigome	967	10	and	and	CC
cord-264884-ydkigome	967	11	we	-PRON-	PRP
cord-264884-ydkigome	967	12	do	do	VBP
cord-264884-ydkigome	967	13	not	not	RB
cord-264884-ydkigome	967	14	see	see	VB
cord-264884-ydkigome	967	15	ongoing	ongoing	JJ
cord-264884-ydkigome	967	16	evidence	evidence	NN
cord-264884-ydkigome	967	17	that	that	IN
cord-264884-ydkigome	967	18	any	any	DT
cord-264884-ydkigome	967	19	HERVs	HERVs	NNPS
cord-264884-ydkigome	967	20	remain	remain	VBP
cord-264884-ydkigome	967	21	active	active	JJ
cord-264884-ydkigome	967	22	.	.	.
cord-264884-ydkigome	968	1	However	however	RB
cord-264884-ydkigome	968	2	,	,	,
cord-264884-ydkigome	968	3	we	-PRON-	PRP
cord-264884-ydkigome	968	4	are	be	VBP
cord-264884-ydkigome	968	5	currently	currently	RB
cord-264884-ydkigome	968	6	witnessing	witness	VBG
cord-264884-ydkigome	968	7	a	a	DT
cord-264884-ydkigome	968	8	related	related	JJ
cord-264884-ydkigome	968	9	virus	virus	NN
cord-264884-ydkigome	968	10	-	-	HYPH
cord-264884-ydkigome	968	11	host	host	NN
cord-264884-ydkigome	968	12	evolutionary	evolutionary	JJ
cord-264884-ydkigome	968	13	event	event	NN
cord-264884-ydkigome	968	14	of	of	IN
cord-264884-ydkigome	968	15	considerable	considerable	JJ
cord-264884-ydkigome	968	16	interest	interest	NN
cord-264884-ydkigome	968	17	.	.	.
cord-264884-ydkigome	969	1	Koala	Koala	NNP
cord-264884-ydkigome	969	2	bears	bear	VBZ
cord-264884-ydkigome	969	3	,	,	,
cord-264884-ydkigome	969	4	native	native	JJ
cord-264884-ydkigome	969	5	marsupials	marsupial	NNS
cord-264884-ydkigome	969	6	of	of	IN
cord-264884-ydkigome	969	7	Australia	Australia	NNP
cord-264884-ydkigome	969	8	,	,	,
cord-264884-ydkigome	969	9	are	be	VBP
cord-264884-ydkigome	969	10	currently	currently	RB
cord-264884-ydkigome	969	11	experiencing	experience	VBG
cord-264884-ydkigome	969	12	a	a	DT
cord-264884-ydkigome	969	13	major	major	JJ
cord-264884-ydkigome	969	14	epidemic	epidemic	NN
cord-264884-ydkigome	969	15	caused	cause	VBN
cord-264884-ydkigome	969	16	by	by	IN
cord-264884-ydkigome	969	17	a	a	DT
cord-264884-ydkigome	969	18	leukemiainducing	leukemiainduce	VBG
cord-264884-ydkigome	969	19	retrovirus	retrovirus	NN
cord-264884-ydkigome	969	20	.	.	.
cord-264884-ydkigome	970	1	As	as	IN
cord-264884-ydkigome	970	2	a	a	DT
cord-264884-ydkigome	970	3	consequence	consequence	NN
cord-264884-ydkigome	970	4	,	,	,
cord-264884-ydkigome	970	5	they	-PRON-	PRP
cord-264884-ydkigome	970	6	are	be	VBP
cord-264884-ydkigome	970	7	undergoing	undergo	VBG
cord-264884-ydkigome	970	8	massive	massive	JJ
cord-264884-ydkigome	970	9	endogenization	endogenization	NN
cord-264884-ydkigome	970	10	by	by	IN
cord-264884-ydkigome	970	11	a	a	DT
cord-264884-ydkigome	970	12	gammaretrovirus	gammaretrovirus	NN
cord-264884-ydkigome	970	13	(	(	-LRB-
cord-264884-ydkigome	970	14	MLV	MLV	NNP
cord-264884-ydkigome	970	15	-	-	HYPH
cord-264884-ydkigome	970	16	related	relate	VBN
cord-264884-ydkigome	970	17	)	)	-RRB-
cord-264884-ydkigome	970	18	.	.	.
cord-264884-ydkigome	971	1	This	this	DT
cord-264884-ydkigome	971	2	virus	virus	NN
cord-264884-ydkigome	971	3	is	be	VBZ
cord-264884-ydkigome	971	4	similar	similar	JJ
cord-264884-ydkigome	971	5	to	to	IN
cord-264884-ydkigome	971	6	Gibbon	Gibbon	NNP
cord-264884-ydkigome	971	7	ape	ape	NN
cord-264884-ydkigome	971	8	leukemia	leukemia	NN
cord-264884-ydkigome	971	9	virus	virus	NN
cord-264884-ydkigome	971	10	,	,	,
cord-264884-ydkigome	971	11	but	but	CC
cord-264884-ydkigome	971	12	most	most	RBS
cord-264884-ydkigome	971	13	likely	likely	RB
cord-264884-ydkigome	971	14	originated	originate	VBD
cord-264884-ydkigome	971	15	from	from	IN
cord-264884-ydkigome	971	16	rodent	rodent	NN
cord-264884-ydkigome	971	17	ancestry	ancestry	NN
cord-264884-ydkigome	971	18	(	(	-LRB-
cord-264884-ydkigome	971	19	Tarlinton	Tarlinton	NNP
cord-264884-ydkigome	971	20	et	et	NNP
cord-264884-ydkigome	971	21	al	al	NNP
cord-264884-ydkigome	971	22	.	.	NNP
cord-264884-ydkigome	971	23	,	,	,
cord-264884-ydkigome	971	24	2006	2006	CD
cord-264884-ydkigome	971	25	;	;	:
cord-264884-ydkigome	971	26	Fiebig	Fiebig	NNP
cord-264884-ydkigome	971	27	et	et	NNP
cord-264884-ydkigome	971	28	al	al	NNP
cord-264884-ydkigome	971	29	.	.	NNP
cord-264884-ydkigome	971	30	,	,	,
cord-264884-ydkigome	971	31	2006	2006	CD
cord-264884-ydkigome	971	32	)	)	-RRB-
cord-264884-ydkigome	971	33	.	.	.
cord-264884-ydkigome	972	1	The	the	DT
cord-264884-ydkigome	972	2	expectation	expectation	NN
cord-264884-ydkigome	972	3	is	be	VBZ
cord-264884-ydkigome	972	4	that	that	IN
cord-264884-ydkigome	972	5	extinction	extinction	NN
cord-264884-ydkigome	972	6	awaits	await	VBZ
cord-264884-ydkigome	972	7	those	those	DT
cord-264884-ydkigome	972	8	koalas	koala	NNS
cord-264884-ydkigome	972	9	that	that	WDT
cord-264884-ydkigome	972	10	do	do	VBP
cord-264884-ydkigome	972	11	not	not	RB
cord-264884-ydkigome	972	12	adapt	adapt	VB
cord-264884-ydkigome	972	13	or	or	CC
cord-264884-ydkigome	972	14	endogenize	endogenize	VB
cord-264884-ydkigome	972	15	the	the	DT
cord-264884-ydkigome	972	16	retrovirus	retrovirus	NN
cord-264884-ydkigome	972	17	successfully	successfully	RB
cord-264884-ydkigome	972	18	(	(	-LRB-
cord-264884-ydkigome	972	19	Stoye	Stoye	NNP
cord-264884-ydkigome	972	20	,	,	,
cord-264884-ydkigome	972	21	2006	2006	CD
cord-264884-ydkigome	972	22	)	)	-RRB-
cord-264884-ydkigome	972	23	.	.	.
cord-264884-ydkigome	973	1	This	this	DT
cord-264884-ydkigome	973	2	event	event	NN
cord-264884-ydkigome	973	3	has	have	VBZ
cord-264884-ydkigome	973	4	the	the	DT
cord-264884-ydkigome	973	5	appearances	appearance	NNS
cord-264884-ydkigome	973	6	of	of	IN
cord-264884-ydkigome	973	7	a	a	DT
cord-264884-ydkigome	973	8	retroviral	retroviral	NN
cord-264884-ydkigome	973	9	-	-	HYPH
cord-264884-ydkigome	973	10	driven	drive	VBN
cord-264884-ydkigome	973	11	addiction	addiction	NN
cord-264884-ydkigome	973	12	that	that	WDT
cord-264884-ydkigome	973	13	will	will	MD
cord-264884-ydkigome	973	14	result	result	VB
cord-264884-ydkigome	973	15	in	in	IN
cord-264884-ydkigome	973	16	a	a	DT
cord-264884-ydkigome	973	17	genetic	genetic	JJ
cord-264884-ydkigome	973	18	variant	variant	NN
cord-264884-ydkigome	973	19	of	of	IN
cord-264884-ydkigome	973	20	koala	koala	NN
cord-264884-ydkigome	973	21	bear	bear	NNP
cord-264884-ydkigome	973	22	that	that	WDT
cord-264884-ydkigome	973	23	has	have	VBZ
cord-264884-ydkigome	973	24	acquired	acquire	VBN
cord-264884-ydkigome	973	25	a	a	DT
cord-264884-ydkigome	973	26	new	new	JJ
cord-264884-ydkigome	973	27	antiretroviral	antiretroviral	JJ
cord-264884-ydkigome	973	28	state	state	NN
cord-264884-ydkigome	973	29	.	.	.
cord-264884-ydkigome	974	1	This	this	DT
cord-264884-ydkigome	974	2	seems	seem	VBZ
cord-264884-ydkigome	974	3	equivalent	equivalent	JJ
cord-264884-ydkigome	974	4	to	to	IN
cord-264884-ydkigome	974	5	the	the	DT
cord-264884-ydkigome	974	6	expansion	expansion	NN
cord-264884-ydkigome	974	7	of	of	IN
cord-264884-ydkigome	974	8	human	human	JJ
cord-264884-ydkigome	974	9	APOBEC3	apobec3	NN
cord-264884-ydkigome	974	10	;	;	:
cord-264884-ydkigome	974	11	or	or	CC
cord-264884-ydkigome	974	12	perhaps	perhaps	RB
cord-264884-ydkigome	974	13	a	a	DT
cord-264884-ydkigome	974	14	closer	close	JJR
cord-264884-ydkigome	974	15	analogy	analogy	NN
cord-264884-ydkigome	974	16	is	be	VBZ
cord-264884-ydkigome	974	17	the	the	DT
cord-264884-ydkigome	974	18	endogenization	endogenization	NN
cord-264884-ydkigome	974	19	of	of	IN
cord-264884-ydkigome	974	20	a	a	DT
cord-264884-ydkigome	974	21	suppressive	suppressive	JJ
cord-264884-ydkigome	974	22	gag	gag	NN
cord-264884-ydkigome	974	23	as	as	IN
cord-264884-ydkigome	974	24	occurred	occur	VBD
cord-264884-ydkigome	974	25	with	with	IN
cord-264884-ydkigome	974	26	enJSRV	enjsrv	CD
cord-264884-ydkigome	974	27	.	.	.
cord-264884-ydkigome	975	1	The	the	DT
cord-264884-ydkigome	975	2	surviving	survive	VBG
cord-264884-ydkigome	975	3	koala	koala	NN
cord-264884-ydkigome	975	4	bears	bear	NNS
cord-264884-ydkigome	975	5	will	will	MD
cord-264884-ydkigome	975	6	likely	likely	RB
cord-264884-ydkigome	975	7	tolerate	tolerate	VB
cord-264884-ydkigome	975	8	or	or	CC
cord-264884-ydkigome	975	9	be	be	VB
cord-264884-ydkigome	975	10	persistently	persistently	RB
cord-264884-ydkigome	975	11	infected	infect	VBN
cord-264884-ydkigome	975	12	with	with	IN
cord-264884-ydkigome	975	13	this	this	DT
cord-264884-ydkigome	975	14	retrovirus	retrovirus	NN
cord-264884-ydkigome	975	15	pool	pool	NN
cord-264884-ydkigome	975	16	.	.	.
cord-264884-ydkigome	976	1	The	the	DT
cord-264884-ydkigome	976	2	genome	genome	NN
cord-264884-ydkigome	976	3	of	of	IN
cord-264884-ydkigome	976	4	the	the	DT
cord-264884-ydkigome	976	5	species	specie	NNS
cord-264884-ydkigome	976	6	will	will	MD
cord-264884-ydkigome	976	7	have	have	VB
cord-264884-ydkigome	976	8	undergone	undergo	VBN
cord-264884-ydkigome	976	9	considerable	considerable	JJ
cord-264884-ydkigome	976	10	(	(	-LRB-
cord-264884-ydkigome	976	11	but	but	CC
cord-264884-ydkigome	976	12	unpredictable	unpredictable	JJ
cord-264884-ydkigome	976	13	)	)	-RRB-
cord-264884-ydkigome	976	14	genetic	genetic	JJ
cord-264884-ydkigome	976	15	perturbations	perturbation	NNS
cord-264884-ydkigome	976	16	and	and	CC
cord-264884-ydkigome	976	17	likely	likely	RB
cord-264884-ydkigome	976	18	contain	contain	VB
cord-264884-ydkigome	976	19	a	a	DT
cord-264884-ydkigome	976	20	large	large	JJ
cord-264884-ydkigome	976	21	pool	pool	NN
cord-264884-ydkigome	976	22	of	of	IN
cord-264884-ydkigome	976	23	variant	variant	NN
cord-264884-ydkigome	976	24	and	and	CC
cord-264884-ydkigome	976	25	defective	defective	JJ
cord-264884-ydkigome	976	26	retrovirus	retrovirus	NN
cord-264884-ydkigome	976	27	.	.	.
cord-264884-ydkigome	977	1	However	however	RB
cord-264884-ydkigome	977	2	,	,	,
cord-264884-ydkigome	977	3	in	in	IN
cord-264884-ydkigome	977	4	so	so	RB
cord-264884-ydkigome	977	5	doing	do	VBG
cord-264884-ydkigome	977	6	,	,	,
cord-264884-ydkigome	977	7	the	the	DT
cord-264884-ydkigome	977	8	descendent	descendent	JJ
cord-264884-ydkigome	977	9	koalas	koala	NNS
cord-264884-ydkigome	977	10	will	will	MD
cord-264884-ydkigome	977	11	likely	likely	RB
cord-264884-ydkigome	977	12	present	present	VB
cord-264884-ydkigome	977	13	a	a	DT
cord-264884-ydkigome	977	14	biological	biological	JJ
cord-264884-ydkigome	977	15	hazard	hazard	NN
cord-264884-ydkigome	977	16	to	to	IN
cord-264884-ydkigome	977	17	any	any	DT
cord-264884-ydkigome	977	18	koala	koala	NN
cord-264884-ydkigome	977	19	species	specie	NNS
cord-264884-ydkigome	977	20	that	that	WDT
cord-264884-ydkigome	977	21	remain	remain	VBP
cord-264884-ydkigome	977	22	virus	virus	NN
cord-264884-ydkigome	977	23	-	-	HYPH
cord-264884-ydkigome	977	24	free	free	JJ
cord-264884-ydkigome	977	25	(	(	-LRB-
cord-264884-ydkigome	977	26	as	as	IN
cord-264884-ydkigome	977	27	in	in	IN
cord-264884-ydkigome	977	28	virus	virus	NN
cord-264884-ydkigome	977	29	addiction	addiction	NN
cord-264884-ydkigome	977	30	)	)	-RRB-
cord-264884-ydkigome	977	31	.	.	.
cord-264884-ydkigome	978	1	Currently	currently	RB
cord-264884-ydkigome	978	2	,	,	,
cord-264884-ydkigome	978	3	one	one	CD
cord-264884-ydkigome	978	4	island	island	NN
cord-264884-ydkigome	978	5	colony	colony	NN
cord-264884-ydkigome	978	6	of	of	IN
cord-264884-ydkigome	978	7	koalas	koalas	NNPS
cord-264884-ydkigome	978	8	is	be	VBZ
cord-264884-ydkigome	978	9	suffi	suffi	NNP
cord-264884-ydkigome	978	10	ciently	ciently	RB
cord-264884-ydkigome	978	11	isolated	isolate	VBN
cord-264884-ydkigome	978	12	to	to	TO
cord-264884-ydkigome	978	13	have	have	VB
cord-264884-ydkigome	978	14	remained	remain	VBN
cord-264884-ydkigome	978	15	virus	virus	NN
cord-264884-ydkigome	978	16	-	-	HYPH
cord-264884-ydkigome	978	17	free	free	JJ
cord-264884-ydkigome	978	18	.	.	.
cord-264884-ydkigome	979	1	This	this	DT
cord-264884-ydkigome	979	2	population	population	NN
cord-264884-ydkigome	979	3	will	will	MD
cord-264884-ydkigome	979	4	henceforth	henceforth	RB
cord-264884-ydkigome	979	5	be	be	VB
cord-264884-ydkigome	979	6	under	under	IN
cord-264884-ydkigome	979	7	persistent	persistent	JJ
cord-264884-ydkigome	979	8	threat	threat	NN
cord-264884-ydkigome	979	9	from	from	IN
cord-264884-ydkigome	979	10	populations	population	NNS
cord-264884-ydkigome	979	11	of	of	IN
cord-264884-ydkigome	979	12	endogenized	endogenize	VBN
cord-264884-ydkigome	979	13	koalas	koala	NNS
cord-264884-ydkigome	979	14	,	,	,
cord-264884-ydkigome	979	15	now	now	RB
cord-264884-ydkigome	979	16	favored	favor	VBN
cord-264884-ydkigome	979	17	by	by	IN
cord-264884-ydkigome	979	18	group	group	NN
cord-264884-ydkigome	979	19	selection	selection	NN
cord-264884-ydkigome	979	20	.	.	.
cord-264884-ydkigome	980	1	From	from	IN
cord-264884-ydkigome	980	2	the	the	DT
cord-264884-ydkigome	980	3	very	very	RB
cord-264884-ydkigome	980	4	earliest	early	JJS
cord-264884-ydkigome	980	5	events	event	NNS
cord-264884-ydkigome	980	6	in	in	IN
cord-264884-ydkigome	980	7	evolution	evolution	NN
cord-264884-ydkigome	980	8	of	of	IN
cord-264884-ydkigome	980	9	prebiotic	prebiotic	JJ
cord-264884-ydkigome	980	10	replicators	replicator	NNS
cord-264884-ydkigome	980	11	to	to	IN
cord-264884-ydkigome	980	12	very	very	RB
cord-264884-ydkigome	980	13	recent	recent	JJ
cord-264884-ydkigome	980	14	events	event	NNS
cord-264884-ydkigome	980	15	in	in	IN
cord-264884-ydkigome	980	16	human	human	JJ
cord-264884-ydkigome	980	17	evolution	evolution	NN
cord-264884-ydkigome	980	18	,	,	,
cord-264884-ydkigome	980	19	including	include	VBG
cord-264884-ydkigome	980	20	the	the	DT
cord-264884-ydkigome	980	21	emergence	emergence	NN
cord-264884-ydkigome	980	22	of	of	IN
cord-264884-ydkigome	980	23	human	human	NN
cord-264884-ydkigome	980	24	-	-	HYPH
cord-264884-ydkigome	980	25	specifi	specifi	NN
cord-264884-ydkigome	980	26	c	c	NN
cord-264884-ydkigome	980	27	HIV	HIV	NNP
cord-264884-ydkigome	980	28	,	,	,
cord-264884-ydkigome	980	29	we	-PRON-	PRP
cord-264884-ydkigome	980	30	expect	expect	VBP
cord-264884-ydkigome	980	31	viral	viral	JJ
cord-264884-ydkigome	980	32	evolution	evolution	NN
cord-264884-ydkigome	980	33	to	to	TO
cord-264884-ydkigome	980	34	show	show	VB
cord-264884-ydkigome	980	35	profound	profound	JJ
cord-264884-ydkigome	980	36	effects	effect	NNS
cord-264884-ydkigome	980	37	on	on	IN
cord-264884-ydkigome	980	38	the	the	DT
cord-264884-ydkigome	980	39	evolution	evolution	NN
cord-264884-ydkigome	980	40	of	of	IN
cord-264884-ydkigome	980	41	all	all	DT
cord-264884-ydkigome	980	42	life	life	NN
cord-264884-ydkigome	980	43	.	.	.
cord-264884-ydkigome	981	1	Unlike	unlike	IN
cord-264884-ydkigome	981	2	accepted	accept	VBN
cord-264884-ydkigome	981	3	host	host	NN
cord-264884-ydkigome	981	4	evolution	evolution	NN
cord-264884-ydkigome	981	5	,	,	,
cord-264884-ydkigome	981	6	viruses	virus	NNS
cord-264884-ydkigome	981	7	also	also	RB
cord-264884-ydkigome	981	8	employ	employ	VBP
cord-264884-ydkigome	981	9	consortia	consortium	NNS
cord-264884-ydkigome	981	10	and	and	CC
cord-264884-ydkigome	981	11	mixed	mixed	JJ
cord-264884-ydkigome	981	12	populations	population	NNS
cord-264884-ydkigome	981	13	to	to	TO
cord-264884-ydkigome	981	14	evolve	evolve	VB
cord-264884-ydkigome	981	15	,	,	,
cord-264884-ydkigome	981	16	sometimes	sometimes	RB
cord-264884-ydkigome	981	17	at	at	IN
cord-264884-ydkigome	981	18	unprecedented	unprecedented	JJ
cord-264884-ydkigome	981	19	rates	rate	NNS
cord-264884-ydkigome	981	20	.	.	.
cord-264884-ydkigome	982	1	Thus	thus	RB
cord-264884-ydkigome	982	2	viruses	virus	NNS
cord-264884-ydkigome	982	3	have	have	VBP
cord-264884-ydkigome	982	4	informed	inform	VBN
cord-264884-ydkigome	982	5	us	-PRON-	PRP
cord-264884-ydkigome	982	6	of	of	IN
cord-264884-ydkigome	982	7	quasispecies	quasispecie	NNS
cord-264884-ydkigome	982	8	,	,	,
cord-264884-ydkigome	982	9	group	group	NN
cord-264884-ydkigome	982	10	dynamics	dynamic	NNS
cord-264884-ydkigome	982	11	,	,	,
cord-264884-ydkigome	982	12	and	and	CC
cord-264884-ydkigome	982	13	group	group	NN
cord-264884-ydkigome	982	14	selection	selection	NN
cord-264884-ydkigome	982	15	in	in	IN
cord-264884-ydkigome	982	16	evolution	evolution	NN
cord-264884-ydkigome	982	17	.	.	.
cord-264884-ydkigome	983	1	Virus	virus	NN
cord-264884-ydkigome	983	2	evolution	evolution	NN
cord-264884-ydkigome	983	3	should	should	MD
cord-264884-ydkigome	983	4	now	now	RB
cord-264884-ydkigome	983	5	be	be	VB
cord-264884-ydkigome	983	6	considered	consider	VBN
cord-264884-ydkigome	983	7	as	as	IN
cord-264884-ydkigome	983	8	basic	basic	JJ
cord-264884-ydkigome	983	9	science	science	NN
cord-264884-ydkigome	983	10	,	,	,
cord-264884-ydkigome	983	11	not	not	RB
cord-264884-ydkigome	983	12	just	just	RB
cord-264884-ydkigome	983	13	a	a	DT
cord-264884-ydkigome	983	14	medical	medical	JJ
cord-264884-ydkigome	983	15	concern	concern	NN
cord-264884-ydkigome	983	16	.	.	.
cord-264884-ydkigome	984	1	We	-PRON-	PRP
cord-264884-ydkigome	984	2	must	must	MD
cord-264884-ydkigome	984	3	acknowledge	acknowledge	VB
cord-264884-ydkigome	984	4	that	that	IN
cord-264884-ydkigome	984	5	the	the	DT
cord-264884-ydkigome	984	6	tree	tree	NN
cord-264884-ydkigome	984	7	of	of	IN
cord-264884-ydkigome	984	8	life	life	NN
cord-264884-ydkigome	984	9	can	can	MD
cord-264884-ydkigome	984	10	not	not	RB
cord-264884-ydkigome	984	11	be	be	VB
cord-264884-ydkigome	984	12	properly	properly	RB
cord-264884-ydkigome	984	13	understood	understand	VBN
cord-264884-ydkigome	984	14	without	without	IN
cord-264884-ydkigome	984	15	virus	virus	NN
cord-264884-ydkigome	984	16	evolution	evolution	NN
cord-264884-ydkigome	984	17	.	.	.
cord-264884-ydkigome	985	1	This	this	DT
cord-264884-ydkigome	985	2	book	book	NN
cord-264884-ydkigome	985	3	helps	help	VBZ
cord-264884-ydkigome	985	4	to	to	TO
cord-264884-ydkigome	985	5	lay	lay	VB
cord-264884-ydkigome	985	6	the	the	DT
cord-264884-ydkigome	985	7	foundation	foundation	NN
cord-264884-ydkigome	985	8	for	for	IN
cord-264884-ydkigome	985	9	such	such	JJ
cord-264884-ydkigome	985	10	understanding	understanding	NN
cord-264884-ydkigome	985	11	.	.	.
cord-264884-ydkigome	986	1	Epizootic	epizootic	JJ
cord-264884-ydkigome	986	2	diarrhea	diarrhea	NN
cord-264884-ydkigome	986	3	of	of	IN
cord-264884-ydkigome	986	4	infant	infant	NN
cord-264884-ydkigome	986	5	mice	mouse	NNS
cord-264884-ydkigome	986	6	:	:	:
cord-264884-ydkigome	987	1	indentifi	indentifi	NNP
cord-264884-ydkigome	987	2	cation	cation	NNP
cord-264884-ydkigome	987	3	of	of	IN
cord-264884-ydkigome	987	4	the	the	DT
cord-264884-ydkigome	987	5	etiologic	etiologic	NNP
cord-264884-ydkigome	987	6	agent	agent	NN
cord-264884-ydkigome	988	1	The	the	DT
cord-264884-ydkigome	988	2	crystal	crystal	JJ
cord-264884-ydkigome	988	3	structure	structure	NN
cord-264884-ydkigome	988	4	of	of	IN
cord-264884-ydkigome	988	5	a	a	DT
cord-264884-ydkigome	988	6	virus	virus	NN
cord-264884-ydkigome	988	7	-	-	HYPH
cord-264884-ydkigome	988	8	like	like	JJ
cord-264884-ydkigome	988	9	particle	particle	NN
cord-264884-ydkigome	988	10	from	from	IN
cord-264884-ydkigome	988	11	the	the	DT
cord-264884-ydkigome	988	12	hyperthermophilic	hyperthermophilic	NNP
cord-264884-ydkigome	988	13	archaeon	archaeon	NNP
cord-264884-ydkigome	989	1	Pyrococcus	Pyrococcus	NNP
cord-264884-ydkigome	989	2	furiosus	furiosus	NNP
cord-264884-ydkigome	989	3	provides	provide	VBZ
cord-264884-ydkigome	989	4	insight	insight	NN
cord-264884-ydkigome	989	5	into	into	IN
cord-264884-ydkigome	989	6	the	the	DT
cord-264884-ydkigome	989	7	evolution	evolution	NN
cord-264884-ydkigome	989	8	of	of	IN
cord-264884-ydkigome	989	9	viruses	virus	NNS
cord-264884-ydkigome	989	10	Unusual	unusual	JJ
cord-264884-ydkigome	989	11	polymorphisms	polymorphism	NNS
cord-264884-ydkigome	989	12	in	in	IN
cord-264884-ydkigome	989	13	human	human	JJ
cord-264884-ydkigome	989	14	immunodefi	immunodefi	NNP
cord-264884-ydkigome	989	15	ciency	ciency	NNP
cord-264884-ydkigome	989	16	virus	virus	NN
cord-264884-ydkigome	989	17	type	type	NN
cord-264884-ydkigome	989	18	1	1	CD
cord-264884-ydkigome	989	19	associated	associate	VBN
cord-264884-ydkigome	989	20	with	with	IN
cord-264884-ydkigome	989	21	nonprogressive	nonprogressive	JJ
cord-264884-ydkigome	989	22	infection	infection	NN
cord-264884-ydkigome	990	1	a	a	LS
cord-264884-ydkigome	990	2	)	)	-RRB-
cord-264884-ydkigome	990	3	Genome	genome	NN
cord-264884-ydkigome	990	4	comparison	comparison	NN
cord-264884-ydkigome	990	5	of	of	IN
cord-264884-ydkigome	990	6	two	two	CD
cord-264884-ydkigome	990	7	Coccolithoviruses	Coccolithoviruses	NNP
cord-264884-ydkigome	990	8	b	b	NN
cord-264884-ydkigome	990	9	)	)	-RRB-
cord-264884-ydkigome	991	1	Evolutionary	evolutionary	JJ
cord-264884-ydkigome	991	2	history	history	NN
cord-264884-ydkigome	991	3	of	of	IN
cord-264884-ydkigome	991	4	the	the	DT
cord-264884-ydkigome	991	5	Coccolithoviridae	Coccolithoviridae	NNP
cord-264884-ydkigome	991	6	Retroelements	Retroelements	NNP
cord-264884-ydkigome	991	7	in	in	IN
cord-264884-ydkigome	991	8	the	the	DT
cord-264884-ydkigome	991	9	human	human	JJ
cord-264884-ydkigome	991	10	MHC	MHC	NNP
cord-264884-ydkigome	991	11	class	class	NN
cord-264884-ydkigome	991	12	II	II	NNP
cord-264884-ydkigome	991	13	region	region	NN
cord-264884-ydkigome	991	14	Host	host	NN
cord-264884-ydkigome	991	15	switching	switch	VBG
cord-264884-ydkigome	991	16	in	in	IN
cord-264884-ydkigome	991	17	Lyssavirus	Lyssavirus	NNP
cord-264884-ydkigome	991	18	history	history	NN
cord-264884-ydkigome	991	19	from	from	IN
cord-264884-ydkigome	991	20	the	the	DT
cord-264884-ydkigome	991	21	Chiroptera	Chiroptera	NNP
cord-264884-ydkigome	991	22	to	to	IN
cord-264884-ydkigome	991	23	the	the	DT
cord-264884-ydkigome	991	24	Carnivora	Carnivora	NNP
cord-264884-ydkigome	991	25	orders	order	NNS
cord-264884-ydkigome	991	26	Common	common	JJ
cord-264884-ydkigome	991	27	ancestry	ancestry	NN
cord-264884-ydkigome	991	28	of	of	IN
cord-264884-ydkigome	991	29	herpesviruses	herpesviruses	NNP
cord-264884-ydkigome	991	30	and	and	CC
cord-264884-ydkigome	992	1	tailed	tailed	JJ
cord-264884-ydkigome	992	2	DNA	dna	NN
cord-264884-ydkigome	992	3	bacteriophages	bacteriophage	NNS
cord-264884-ydkigome	992	4	Do	do	VBP
cord-264884-ydkigome	992	5	viruses	virus	NNS
cord-264884-ydkigome	992	6	form	form	VB
cord-264884-ydkigome	992	7	lineages	lineage	NNS
cord-264884-ydkigome	992	8	across	across	IN
cord-264884-ydkigome	992	9	different	different	JJ
cord-264884-ydkigome	992	10	domains	domain	NNS
cord-264884-ydkigome	992	11	of	of	IN
cord-264884-ydkigome	992	12	life	life	NN
cord-264884-ydkigome	992	13	?	?	.
cord-264884-ydkigome	993	1	a	a	LS
cord-264884-ydkigome	993	2	)	)	-RRB-
cord-264884-ydkigome	994	1	What	what	WP
cord-264884-ydkigome	994	2	does	do	VBZ
cord-264884-ydkigome	994	3	structure	structure	NN
cord-264884-ydkigome	994	4	tell	tell	VB
cord-264884-ydkigome	994	5	us	-PRON-	PRP
cord-264884-ydkigome	994	6	about	about	IN
cord-264884-ydkigome	994	7	virus	virus	NN
cord-264884-ydkigome	994	8	evolution	evolution	NN
cord-264884-ydkigome	994	9	?	?	.
cord-264884-ydkigome	995	1	b	b	LS
cord-264884-ydkigome	995	2	)	)	-RRB-
cord-264884-ydkigome	995	3	Constituents	Constituents	NNPS
cord-264884-ydkigome	995	4	of	of	IN
cord-264884-ydkigome	995	5	SH1	SH1	NNP
cord-264884-ydkigome	995	6	,	,	,
cord-264884-ydkigome	995	7	a	a	DT
cord-264884-ydkigome	995	8	novel	novel	JJ
cord-264884-ydkigome	995	9	lipid	lipid	NN
cord-264884-ydkigome	995	10	-	-	HYPH
cord-264884-ydkigome	995	11	containing	contain	VBG
cord-264884-ydkigome	995	12	virus	virus	NN
cord-264884-ydkigome	995	13	infecting	infect	VBG
cord-264884-ydkigome	995	14	the	the	DT
cord-264884-ydkigome	995	15	halophilic	halophilic	NNP
cord-264884-ydkigome	995	16	euryarchaeon	euryarchaeon	NNP
cord-264884-ydkigome	996	1	Haloarcula	Haloarcula	NNP
cord-264884-ydkigome	996	2	hispanica	hispanica	NN
cord-264884-ydkigome	997	1	Ostreid	ostreid	NN
cord-264884-ydkigome	997	2	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	997	3	1	1	CD
cord-264884-ydkigome	997	4	(	(	-LRB-
cord-264884-ydkigome	997	5	OsHV-1	oshv-1	CD
cord-264884-ydkigome	997	6	)	)	-RRB-
cord-264884-ydkigome	997	7	detection	detection	NN
cord-264884-ydkigome	997	8	among	among	IN
cord-264884-ydkigome	997	9	three	three	CD
cord-264884-ydkigome	997	10	successive	successive	JJ
cord-264884-ydkigome	997	11	generations	generation	NNS
cord-264884-ydkigome	997	12	of	of	IN
cord-264884-ydkigome	997	13	Pacifi	Pacifi	NNP
cord-264884-ydkigome	997	14	c	c	NN
cord-264884-ydkigome	997	15	oysters	oyster	NNS
cord-264884-ydkigome	997	16	(	(	-LRB-
cord-264884-ydkigome	997	17	Crassostrea	Crassostrea	NNP
cord-264884-ydkigome	997	18	gigas	gigas	NNP
cord-264884-ydkigome	997	19	)	)	-RRB-
cord-264884-ydkigome	998	1	Persistent	persistent	JJ
cord-264884-ydkigome	998	2	infection	infection	NN
cord-264884-ydkigome	998	3	promotes	promote	VBZ
cord-264884-ydkigome	998	4	cross	cross	NN
cord-264884-ydkigome	998	5	-	-	JJ
cord-264884-ydkigome	998	6	species	species	JJ
cord-264884-ydkigome	998	7	transmissibility	transmissibility	NN
cord-264884-ydkigome	998	8	of	of	IN
cord-264884-ydkigome	998	9	mouse	mouse	NN
cord-264884-ydkigome	998	10	hepatitis	hepatitis	NNP
cord-264884-ydkigome	998	11	virus	virus	NN
cord-264884-ydkigome	999	1	The	the	DT
cord-264884-ydkigome	999	2	proportion	proportion	NN
cord-264884-ydkigome	999	3	of	of	IN
cord-264884-ydkigome	999	4	revertant	revertant	NN
cord-264884-ydkigome	999	5	and	and	CC
cord-264884-ydkigome	999	6	mutant	mutant	JJ
cord-264884-ydkigome	999	7	phage	phage	NN
cord-264884-ydkigome	999	8	in	in	IN
cord-264884-ydkigome	999	9	a	a	DT
cord-264884-ydkigome	999	10	growing	grow	VBG
cord-264884-ydkigome	999	11	population	population	NN
cord-264884-ydkigome	999	12	,	,	,
cord-264884-ydkigome	999	13	as	as	IN
cord-264884-ydkigome	999	14	a	a	DT
cord-264884-ydkigome	999	15	function	function	NN
cord-264884-ydkigome	999	16	of	of	IN
cord-264884-ydkigome	999	17	mutation	mutation	NN
cord-264884-ydkigome	999	18	and	and	CC
cord-264884-ydkigome	999	19	growth	growth	NN
cord-264884-ydkigome	999	20	rate	rate	NN
cord-264884-ydkigome	999	21	An	an	DT
cord-264884-ydkigome	999	22	intron	intron	NN
cord-264884-ydkigome	999	23	in	in	IN
cord-264884-ydkigome	999	24	the	the	DT
cord-264884-ydkigome	999	25	thymidylate	thymidylate	NNP
cord-264884-ydkigome	999	26	synthase	synthase	NN
cord-264884-ydkigome	999	27	gene	gene	NN
cord-264884-ydkigome	999	28	of	of	IN
cord-264884-ydkigome	999	29	Bacillus	Bacillus	NNP
cord-264884-ydkigome	999	30	bacteriophage	bacteriophage	NN
cord-264884-ydkigome	999	31	beta	beta	NN
cord-264884-ydkigome	999	32	22	22	CD
cord-264884-ydkigome	999	33	:	:	:
cord-264884-ydkigome	999	34	evidence	evidence	NN
cord-264884-ydkigome	999	35	for	for	IN
cord-264884-ydkigome	999	36	independent	independent	JJ
cord-264884-ydkigome	999	37	evolution	evolution	NN
cord-264884-ydkigome	999	38	of	of	IN
cord-264884-ydkigome	999	39	a	a	DT
cord-264884-ydkigome	999	40	gene	gene	NN
cord-264884-ydkigome	999	41	,	,	,
cord-264884-ydkigome	999	42	its	-PRON-	PRP$
cord-264884-ydkigome	999	43	group	group	NN
cord-264884-ydkigome	999	44	I	-PRON-	PRP
cord-264884-ydkigome	999	45	intron	intron	NN
cord-264884-ydkigome	999	46	,	,	,
cord-264884-ydkigome	999	47	and	and	CC
cord-264884-ydkigome	999	48	the	the	DT
cord-264884-ydkigome	999	49	intron	intron	NN
cord-264884-ydkigome	999	50	open	open	JJ
cord-264884-ydkigome	999	51	reading	reading	NN
cord-264884-ydkigome	999	52	frame	frame	NN
cord-264884-ydkigome	999	53	Serological	serological	JJ
cord-264884-ydkigome	999	54	survey	survey	NN
cord-264884-ydkigome	999	55	of	of	IN
cord-264884-ydkigome	999	56	virus	virus	NN
cord-264884-ydkigome	999	57	infection	infection	NN
cord-264884-ydkigome	999	58	among	among	IN
cord-264884-ydkigome	999	59	wild	wild	JJ
cord-264884-ydkigome	999	60	house	house	NN
cord-264884-ydkigome	999	61	mice	mouse	NNS
cord-264884-ydkigome	999	62	(	(	-LRB-
cord-264884-ydkigome	999	63	Mus	Mus	NNP
cord-264884-ydkigome	999	64	domesticus	domesticus	NN
cord-264884-ydkigome	999	65	)	)	-RRB-
cord-264884-ydkigome	999	66	in	in	IN
cord-264884-ydkigome	999	67	the	the	DT
cord-264884-ydkigome	999	68	UK	UK	NNP
cord-264884-ydkigome	999	69	Molecular	Molecular	NNP
cord-264884-ydkigome	999	70	Evolution	Evolution	NNP
cord-264884-ydkigome	999	71	of	of	IN
cord-264884-ydkigome	999	72	Viruses	virus	NNS
cord-264884-ydkigome	999	73	,	,	,
cord-264884-ydkigome	999	74	Past	past	NN
cord-264884-ydkigome	999	75	and	and	CC
cord-264884-ydkigome	999	76	Present	present	NN
cord-264884-ydkigome	999	77	:	:	:
cord-264884-ydkigome	999	78	Evolution	evolution	NN
cord-264884-ydkigome	999	79	of	of	IN
cord-264884-ydkigome	999	80	Viruses	Viruses	NNPS
cord-264884-ydkigome	999	81	by	by	IN
cord-264884-ydkigome	999	82	Acquisition	Acquisition	NNP
cord-264884-ydkigome	999	83	of	of	IN
cord-264884-ydkigome	999	84	Cellular	Cellular	NNP
cord-264884-ydkigome	999	85	RNA	RNA	NNP
cord-264884-ydkigome	999	86	and	and	CC
cord-264884-ydkigome	1000	1	DNA	DNA	NNP
cord-264884-ydkigome	1000	2	Viral	viral	JJ
cord-264884-ydkigome	1000	3	eukaryogenesis	eukaryogenesis	NN
cord-264884-ydkigome	1000	4	:	:	:
cord-264884-ydkigome	1000	5	was	be	VBD
cord-264884-ydkigome	1000	6	the	the	DT
cord-264884-ydkigome	1000	7	ancestor	ancestor	NN
cord-264884-ydkigome	1000	8	of	of	IN
cord-264884-ydkigome	1000	9	the	the	DT
cord-264884-ydkigome	1000	10	nucleus	nucleus	NN
cord-264884-ydkigome	1000	11	a	a	DT
cord-264884-ydkigome	1000	12	complex	complex	JJ
cord-264884-ydkigome	1000	13	DNA	dna	NN
cord-264884-ydkigome	1000	14	virus	virus	NN
cord-264884-ydkigome	1000	15	?	?	.
cord-264884-ydkigome	1001	1	Sex	sex	NN
cord-264884-ydkigome	1001	2	and	and	CC
cord-264884-ydkigome	1001	3	the	the	DT
cord-264884-ydkigome	1001	4	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	1001	5	cell	cell	NN
cord-264884-ydkigome	1001	6	cycle	cycle	NN
cord-264884-ydkigome	1001	7	is	be	VBZ
cord-264884-ydkigome	1001	8	consistent	consistent	JJ
cord-264884-ydkigome	1001	9	with	with	IN
cord-264884-ydkigome	1001	10	a	a	DT
cord-264884-ydkigome	1001	11	viral	viral	JJ
cord-264884-ydkigome	1001	12	ancestry	ancestry	NN
cord-264884-ydkigome	1001	13	for	for	IN
cord-264884-ydkigome	1001	14	the	the	DT
cord-264884-ydkigome	1001	15	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	1001	16	nucleus	nucleus	NN
cord-264884-ydkigome	1001	17	Coexistence	coexistence	NN
cord-264884-ydkigome	1001	18	of	of	IN
cord-264884-ydkigome	1001	19	recent	recent	JJ
cord-264884-ydkigome	1001	20	and	and	CC
cord-264884-ydkigome	1001	21	ancestral	ancestral	JJ
cord-264884-ydkigome	1001	22	nucleotide	nucleotide	JJ
cord-264884-ydkigome	1001	23	sequences	sequence	NNS
cord-264884-ydkigome	1001	24	in	in	IN
cord-264884-ydkigome	1001	25	viral	viral	JJ
cord-264884-ydkigome	1001	26	quasispecies	quasispecie	NNS
cord-264884-ydkigome	1001	27	of	of	IN
cord-264884-ydkigome	1001	28	human	human	JJ
cord-264884-ydkigome	1001	29	immunodefi	immunodefi	NNP
cord-264884-ydkigome	1001	30	ciency	ciency	NNP
cord-264884-ydkigome	1001	31	virus	virus	NN
cord-264884-ydkigome	1001	32	type	type	NN
cord-264884-ydkigome	1001	33	1	1	CD
cord-264884-ydkigome	1001	34	patients	patient	NNS
cord-264884-ydkigome	1002	1	A	a	DT
cord-264884-ydkigome	1002	2	subset	subset	NN
cord-264884-ydkigome	1002	3	of	of	IN
cord-264884-ydkigome	1002	4	human	human	JJ
cord-264884-ydkigome	1002	5	immunodefi	immunodefi	NNP
cord-264884-ydkigome	1002	6	ciency	ciency	NNP
cord-264884-ydkigome	1002	7	virus	virus	NN
cord-264884-ydkigome	1002	8	type	type	NN
cord-264884-ydkigome	1002	9	1	1	CD
cord-264884-ydkigome	1002	10	long	long	JJ
cord-264884-ydkigome	1002	11	-	-	HYPH
cord-264884-ydkigome	1002	12	term	term	NN
cord-264884-ydkigome	1002	13	nonprogressors	nonprogressor	NNS
cord-264884-ydkigome	1002	14	is	be	VBZ
cord-264884-ydkigome	1002	15	characterized	characterize	VBN
cord-264884-ydkigome	1002	16	by	by	IN
cord-264884-ydkigome	1002	17	the	the	DT
cord-264884-ydkigome	1002	18	unique	unique	JJ
cord-264884-ydkigome	1002	19	presence	presence	NN
cord-264884-ydkigome	1002	20	of	of	IN
cord-264884-ydkigome	1002	21	ancestral	ancestral	JJ
cord-264884-ydkigome	1002	22	sequences	sequence	NNS
cord-264884-ydkigome	1002	23	in	in	IN
cord-264884-ydkigome	1002	24	the	the	DT
cord-264884-ydkigome	1002	25	viral	viral	JJ
cord-264884-ydkigome	1002	26	population	population	NN
cord-264884-ydkigome	1002	27	Does	do	VBZ
cord-264884-ydkigome	1002	28	common	common	JJ
cord-264884-ydkigome	1002	29	architecture	architecture	NN
cord-264884-ydkigome	1002	30	reveal	reveal	VBP
cord-264884-ydkigome	1002	31	a	a	DT
cord-264884-ydkigome	1002	32	viral	viral	JJ
cord-264884-ydkigome	1002	33	lineage	lineage	NN
cord-264884-ydkigome	1002	34	spanning	span	VBG
cord-264884-ydkigome	1002	35	all	all	DT
cord-264884-ydkigome	1002	36	three	three	CD
cord-264884-ydkigome	1002	37	domains	domain	NNS
cord-264884-ydkigome	1002	38	of	of	IN
cord-264884-ydkigome	1002	39	life	life	NN
cord-264884-ydkigome	1002	40	?	?	.
cord-264884-ydkigome	1003	1	The	the	DT
cord-264884-ydkigome	1003	2	error	error	NN
cord-264884-ydkigome	1003	3	threshold	threshold	NN
cord-264884-ydkigome	1004	1	What	what	WP
cord-264884-ydkigome	1004	2	is	be	VBZ
cord-264884-ydkigome	1004	3	a	a	DT
cord-264884-ydkigome	1004	4	quasispecies	quasispecie	NNS
cord-264884-ydkigome	1004	5	An	an	DT
cord-264884-ydkigome	1004	6	envelope	envelope	NN
cord-264884-ydkigome	1004	7	glycoprotein	glycoprotein	NN
cord-264884-ydkigome	1004	8	of	of	IN
cord-264884-ydkigome	1004	9	the	the	DT
cord-264884-ydkigome	1004	10	human	human	JJ
cord-264884-ydkigome	1004	11	endogenous	endogenous	JJ
cord-264884-ydkigome	1004	12	retrovirus	retrovirus	NN
cord-264884-ydkigome	1004	13	HERV	HERV	NNP
cord-264884-ydkigome	1004	14	-	-	HYPH
cord-264884-ydkigome	1004	15	W	W	NNP
cord-264884-ydkigome	1004	16	is	be	VBZ
cord-264884-ydkigome	1004	17	expressed	express	VBN
cord-264884-ydkigome	1004	18	in	in	IN
cord-264884-ydkigome	1004	19	the	the	DT
cord-264884-ydkigome	1004	20	human	human	JJ
cord-264884-ydkigome	1004	21	placenta	placenta	NN
cord-264884-ydkigome	1004	22	and	and	CC
cord-264884-ydkigome	1004	23	fuses	fuse	NNS
cord-264884-ydkigome	1004	24	cells	cell	NNS
cord-264884-ydkigome	1004	25	expressing	express	VBG
cord-264884-ydkigome	1004	26	the	the	DT
cord-264884-ydkigome	1004	27	type	type	NN
cord-264884-ydkigome	1004	28	D	D	NNP
cord-264884-ydkigome	1004	29	mammalian	mammalian	JJ
cord-264884-ydkigome	1004	30	retrovirus	retrovirus	NN
cord-264884-ydkigome	1004	31	receptor	receptor	NN
cord-264884-ydkigome	1004	32	The	the	DT
cord-264884-ydkigome	1004	33	genome	genome	NN
cord-264884-ydkigome	1004	34	of	of	IN
cord-264884-ydkigome	1004	35	the	the	DT
cord-264884-ydkigome	1004	36	archaeal	archaeal	JJ
cord-264884-ydkigome	1004	37	virus	virus	NN
cord-264884-ydkigome	1004	38	SIRV1	SIRV1	NNP
cord-264884-ydkigome	1004	39	has	have	VBZ
cord-264884-ydkigome	1004	40	features	feature	NNS
cord-264884-ydkigome	1004	41	in	in	IN
cord-264884-ydkigome	1004	42	common	common	JJ
cord-264884-ydkigome	1004	43	with	with	IN
cord-264884-ydkigome	1004	44	genomes	genome	NNS
cord-264884-ydkigome	1004	45	of	of	IN
cord-264884-ydkigome	1004	46	eukaryal	eukaryal	NN
cord-264884-ydkigome	1004	47	viruses	virus	NNS
cord-264884-ydkigome	1004	48	Oceanographic	oceanographic	JJ
cord-264884-ydkigome	1004	49	basis	basis	NN
cord-264884-ydkigome	1004	50	of	of	IN
cord-264884-ydkigome	1004	51	the	the	DT
cord-264884-ydkigome	1004	52	global	global	JJ
cord-264884-ydkigome	1004	53	surface	surface	NN
cord-264884-ydkigome	1004	54	distribution	distribution	NN
cord-264884-ydkigome	1004	55	of	of	IN
cord-264884-ydkigome	1004	56	Prochlorococcus	Prochlorococcus	NNP
cord-264884-ydkigome	1004	57	ecotypes	ecotype	VBZ
cord-264884-ydkigome	1004	58	a	a	DT
cord-264884-ydkigome	1004	59	)	)	-RRB-
cord-264884-ydkigome	1005	1	Here	here	RB
cord-264884-ydkigome	1005	2	a	a	DT
cord-264884-ydkigome	1005	3	virus	virus	NN
cord-264884-ydkigome	1005	4	,	,	,
cord-264884-ydkigome	1005	5	there	there	EX
cord-264884-ydkigome	1005	6	a	a	DT
cord-264884-ydkigome	1005	7	virus	virus	NN
cord-264884-ydkigome	1005	8	,	,	,
cord-264884-ydkigome	1005	9	everywhere	everywhere	RB
cord-264884-ydkigome	1005	10	the	the	DT
cord-264884-ydkigome	1005	11	same	same	JJ
cord-264884-ydkigome	1005	12	virus	virus	NN
cord-264884-ydkigome	1005	13	?	?	.
cord-264884-ydkigome	1006	1	b	b	LS
cord-264884-ydkigome	1006	2	)	)	-RRB-
cord-264884-ydkigome	1006	3	Method	method	NN
cord-264884-ydkigome	1006	4	for	for	IN
cord-264884-ydkigome	1006	5	discovering	discover	VBG
cord-264884-ydkigome	1006	6	novel	novel	JJ
cord-264884-ydkigome	1006	7	DNA	dna	NN
cord-264884-ydkigome	1006	8	viruses	virus	NNS
cord-264884-ydkigome	1006	9	in	in	IN
cord-264884-ydkigome	1006	10	blood	blood	NN
cord-264884-ydkigome	1006	11	using	use	VBG
cord-264884-ydkigome	1006	12	viral	viral	JJ
cord-264884-ydkigome	1006	13	particle	particle	NN
cord-264884-ydkigome	1006	14	selection	selection	NN
cord-264884-ydkigome	1006	15	and	and	CC
cord-264884-ydkigome	1006	16	shotgun	shotgun	NN
cord-264884-ydkigome	1006	17	sequencing	sequence	VBG
cord-264884-ydkigome	1006	18	Metagenomic	Metagenomic	NNP
cord-264884-ydkigome	1006	19	analyses	analysis	NNS
cord-264884-ydkigome	1006	20	of	of	IN
cord-264884-ydkigome	1006	21	an	an	DT
cord-264884-ydkigome	1006	22	uncultured	uncultured	JJ
cord-264884-ydkigome	1006	23	viral	viral	JJ
cord-264884-ydkigome	1006	24	community	community	NN
cord-264884-ydkigome	1006	25	from	from	IN
cord-264884-ydkigome	1006	26	human	human	JJ
cord-264884-ydkigome	1006	27	feces	fece	NNS
cord-264884-ydkigome	1006	28	Minority	minority	NN
cord-264884-ydkigome	1006	29	memory	memory	NN
cord-264884-ydkigome	1006	30	genomes	genome	NNS
cord-264884-ydkigome	1006	31	can	can	MD
cord-264884-ydkigome	1006	32	infl	infl	VB
cord-264884-ydkigome	1006	33	uence	uence	VB
cord-264884-ydkigome	1006	34	the	the	DT
cord-264884-ydkigome	1006	35	evolution	evolution	NN
cord-264884-ydkigome	1006	36	of	of	IN
cord-264884-ydkigome	1006	37	HIV-1	HIV-1	NNP
cord-264884-ydkigome	1006	38	quasispecies	quasispecie	NNS
cord-264884-ydkigome	1006	39	in	in	IN
cord-264884-ydkigome	1006	40	vivo	vivo	NNP
cord-264884-ydkigome	1006	41	Phages	Phages	NNPS
cord-264884-ydkigome	1006	42	and	and	CC
cord-264884-ydkigome	1006	43	the	the	DT
cord-264884-ydkigome	1006	44	evolution	evolution	NN
cord-264884-ydkigome	1006	45	of	of	IN
cord-264884-ydkigome	1006	46	bacterial	bacterial	JJ
cord-264884-ydkigome	1006	47	pathogens	pathogen	NNS
cord-264884-ydkigome	1006	48	:	:	:
cord-264884-ydkigome	1006	49	from	from	IN
cord-264884-ydkigome	1006	50	genomic	genomic	JJ
cord-264884-ydkigome	1006	51	rearrangements	rearrangement	NNS
cord-264884-ydkigome	1006	52	to	to	IN
cord-264884-ydkigome	1006	53	lysogenic	lysogenic	JJ
cord-264884-ydkigome	1006	54	conversion	conversion	NN
cord-264884-ydkigome	1006	55	.	.	.
cord-264884-ydkigome	1007	1	Microbiol	Microbiol	NNP
cord-264884-ydkigome	1008	1	The	the	DT
cord-264884-ydkigome	1008	2	gene	gene	NN
cord-264884-ydkigome	1008	3	of	of	IN
cord-264884-ydkigome	1008	4	retroviral	retroviral	JJ
cord-264884-ydkigome	1008	5	origin	origin	NN
cord-264884-ydkigome	1008	6	Syncytin	Syncytin	NNP
cord-264884-ydkigome	1008	7	1	1	CD
cord-264884-ydkigome	1008	8	is	be	VBZ
cord-264884-ydkigome	1008	9	specifi	specifi	VBN
cord-264884-ydkigome	1008	10	c	c	NN
cord-264884-ydkigome	1008	11	to	to	IN
cord-264884-ydkigome	1008	12	hominoids	hominoid	NNS
cord-264884-ydkigome	1008	13	and	and	CC
cord-264884-ydkigome	1008	14	is	be	VBZ
cord-264884-ydkigome	1008	15	inactive	inactive	JJ
cord-264884-ydkigome	1008	16	in	in	IN
cord-264884-ydkigome	1008	17	Old	Old	NNP
cord-264884-ydkigome	1008	18	World	World	NNP
cord-264884-ydkigome	1008	19	monkeys	monkey	NNS
cord-264884-ydkigome	1008	20	Phage	phage	NN
cord-264884-ydkigome	1008	21	integration	integration	NN
cord-264884-ydkigome	1008	22	and	and	CC
cord-264884-ydkigome	1008	23	chromosome	chromosome	NN
cord-264884-ydkigome	1008	24	structure	structure	NN
cord-264884-ydkigome	1008	25	.	.	.
cord-264884-ydkigome	1009	1	A	a	DT
cord-264884-ydkigome	1009	2	personal	personal	JJ
cord-264884-ydkigome	1009	3	history	history	NN
cord-264884-ydkigome	1010	1	Lambdoid	Lambdoid	NNP
cord-264884-ydkigome	1010	2	phages	phage	NNS
cord-264884-ydkigome	1010	3	as	as	IN
cord-264884-ydkigome	1010	4	elements	element	NNS
cord-264884-ydkigome	1010	5	of	of	IN
cord-264884-ydkigome	1010	6	bacterial	bacterial	JJ
cord-264884-ydkigome	1010	7	genomes	genome	NNS
cord-264884-ydkigome	1010	8	Phage	Phage	NNP
cord-264884-ydkigome	1010	9	as	as	IN
cord-264884-ydkigome	1010	10	agents	agent	NNS
cord-264884-ydkigome	1010	11	of	of	IN
cord-264884-ydkigome	1010	12	lateral	lateral	JJ
cord-264884-ydkigome	1010	13	gene	gene	NN
cord-264884-ydkigome	1010	14	transfer	transfer	NN
cord-264884-ydkigome	1011	1	The	the	DT
cord-264884-ydkigome	1011	2	impact	impact	NN
cord-264884-ydkigome	1011	3	of	of	IN
cord-264884-ydkigome	1011	4	prophages	prophage	NNS
cord-264884-ydkigome	1011	5	on	on	IN
cord-264884-ydkigome	1011	6	bacterial	bacterial	JJ
cord-264884-ydkigome	1011	7	chromosomes	chromosome	NNS
cord-264884-ydkigome	1011	8	Differences	difference	NNS
cord-264884-ydkigome	1011	9	in	in	IN
cord-264884-ydkigome	1011	10	frequencies	frequency	NNS
cord-264884-ydkigome	1011	11	of	of	IN
cord-264884-ydkigome	1011	12	drug	drug	NN
cord-264884-ydkigome	1011	13	resistance	resistance	NN
cord-264884-ydkigome	1011	14	-	-	HYPH
cord-264884-ydkigome	1011	15	associated	associate	VBN
cord-264884-ydkigome	1011	16	mutations	mutation	NNS
cord-264884-ydkigome	1011	17	in	in	IN
cord-264884-ydkigome	1011	18	the	the	DT
cord-264884-ydkigome	1011	19	HIV-1	HIV-1	NNP
cord-264884-ydkigome	1011	20	pol	pol	NN
cord-264884-ydkigome	1011	21	gene	gene	NN
cord-264884-ydkigome	1011	22	of	of	IN
cord-264884-ydkigome	1011	23	B	B	NNP
cord-264884-ydkigome	1011	24	subtype	subtype	NN
cord-264884-ydkigome	1011	25	and	and	CC
cord-264884-ydkigome	1011	26	BF	BF	NNP
cord-264884-ydkigome	1011	27	intersubtype	intersubtype	NN
cord-264884-ydkigome	1011	28	recombinant	recombinant	NN
cord-264884-ydkigome	1011	29	samples	sample	VBZ
cord-264884-ydkigome	1011	30	Lethal	lethal	JJ
cord-264884-ydkigome	1011	31	intestinal	intestinal	JJ
cord-264884-ydkigome	1011	32	virus	virus	NN
cord-264884-ydkigome	1011	33	of	of	IN
cord-264884-ydkigome	1011	34	infant	infant	NN
cord-264884-ydkigome	1011	35	mice	mouse	NNS
cord-264884-ydkigome	1011	36	is	be	VBZ
cord-264884-ydkigome	1011	37	mouse	mouse	NNP
cord-264884-ydkigome	1011	38	hepatitis	hepatitis	NNP
cord-264884-ydkigome	1011	39	virus	virus	NN
cord-264884-ydkigome	1012	1	Different	different	JJ
cord-264884-ydkigome	1012	2	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1012	3	patterns	pattern	NNS
cord-264884-ydkigome	1012	4	are	be	VBP
cord-264884-ydkigome	1012	5	found	find	VBN
cord-264884-ydkigome	1012	6	within	within	IN
cord-264884-ydkigome	1012	7	human	human	JJ
cord-264884-ydkigome	1012	8	immunodefi	immunodefi	NNP
cord-264884-ydkigome	1012	9	ciency	ciency	NNP
cord-264884-ydkigome	1012	10	virus	virus	NN
cord-264884-ydkigome	1012	11	type	type	NN
cord-264884-ydkigome	1012	12	1-infected	1-infected	CD
cord-264884-ydkigome	1012	13	patients	patient	NNS
cord-264884-ydkigome	1013	1	The	the	DT
cord-264884-ydkigome	1013	2	pK02	pk02	JJ
cord-264884-ydkigome	1013	3	linear	linear	JJ
cord-264884-ydkigome	1013	4	plasmid	plasmid	NN
cord-264884-ydkigome	1013	5	prophage	prophage	NN
cord-264884-ydkigome	1013	6	of	of	IN
cord-264884-ydkigome	1013	7	Klebsiella	Klebsiella	NNP
cord-264884-ydkigome	1013	8	oxytoca	oxytoca	VBZ
cord-264884-ydkigome	1013	9	Two	two	CD
cord-264884-ydkigome	1013	10	proton	proton	NN
cord-264884-ydkigome	1013	11	transfers	transfer	NNS
cord-264884-ydkigome	1013	12	in	in	IN
cord-264884-ydkigome	1013	13	the	the	DT
cord-264884-ydkigome	1013	14	transition	transition	NN
cord-264884-ydkigome	1013	15	state	state	NN
cord-264884-ydkigome	1013	16	for	for	IN
cord-264884-ydkigome	1013	17	nucleotidyl	nucleotidyl	NNP
cord-264884-ydkigome	1013	18	transfer	transfer	NN
cord-264884-ydkigome	1013	19	catalyzed	catalyze	VBN
cord-264884-ydkigome	1013	20	by	by	IN
cord-264884-ydkigome	1013	21	RNA	RNA	NNP
cord-264884-ydkigome	1013	22	-	-	:
cord-264884-ydkigome	1013	23	and	and	CC
cord-264884-ydkigome	1013	24	DNA	dna	NN
cord-264884-ydkigome	1013	25	-	-	HYPH
cord-264884-ydkigome	1013	26	dependent	dependent	JJ
cord-264884-ydkigome	1013	27	RNA	RNA	NNP
cord-264884-ydkigome	1013	28	and	and	CC
cord-264884-ydkigome	1013	29	DNA	dna	NN
cord-264884-ydkigome	1013	30	polymerases	polymerase	NNS
cord-264884-ydkigome	1014	1	Sequences	sequence	NNS
cord-264884-ydkigome	1014	2	homologous	homologous	JJ
cord-264884-ydkigome	1014	3	to	to	IN
cord-264884-ydkigome	1014	4	yeast	yeast	NN
cord-264884-ydkigome	1014	5	mitochondrial	mitochondrial	NN
cord-264884-ydkigome	1014	6	and	and	CC
cord-264884-ydkigome	1014	7	bacteriophage	bacteriophage	NN
cord-264884-ydkigome	1014	8	T3	T3	NNP
cord-264884-ydkigome	1014	9	and	and	CC
cord-264884-ydkigome	1015	1	T7	T7	NNP
cord-264884-ydkigome	1015	2	RNA	RNA	NNP
cord-264884-ydkigome	1015	3	polymerases	polymerase	NNS
cord-264884-ydkigome	1015	4	are	be	VBP
cord-264884-ydkigome	1015	5	widespread	widespread	JJ
cord-264884-ydkigome	1015	6	throughout	throughout	IN
cord-264884-ydkigome	1015	7	the	the	DT
cord-264884-ydkigome	1015	8	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	1015	9	lineage	lineage	NN
cord-264884-ydkigome	1015	10	Cowpox	Cowpox	NNP
cord-264884-ydkigome	1015	11	:	:	:
cord-264884-ydkigome	1015	12	reservoir	reservoir	NNP
cord-264884-ydkigome	1015	13	hosts	host	NNS
cord-264884-ydkigome	1015	14	and	and	CC
cord-264884-ydkigome	1015	15	geographic	geographic	JJ
cord-264884-ydkigome	1015	16	range	range	NN
cord-264884-ydkigome	1016	1	A	a	DT
cord-264884-ydkigome	1016	2	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	1016	3	survey	survey	NN
cord-264884-ydkigome	1016	4	of	of	IN
cord-264884-ydkigome	1016	5	recombination	recombination	NN
cord-264884-ydkigome	1016	6	frequency	frequency	NN
cord-264884-ydkigome	1016	7	in	in	IN
cord-264884-ydkigome	1016	8	plant	plant	NN
cord-264884-ydkigome	1016	9	RNA	RNA	NNP
cord-264884-ydkigome	1016	10	viruses	virus	NNS
cord-264884-ydkigome	1016	11	Role	role	NN
cord-264884-ydkigome	1016	12	of	of	IN
cord-264884-ydkigome	1016	13	minority	minority	NN
cord-264884-ydkigome	1016	14	populations	population	NNS
cord-264884-ydkigome	1016	15	of	of	IN
cord-264884-ydkigome	1016	16	human	human	JJ
cord-264884-ydkigome	1016	17	immunodefi	immunodefi	NNP
cord-264884-ydkigome	1016	18	ciency	ciency	NNP
cord-264884-ydkigome	1016	19	virus	virus	NN
cord-264884-ydkigome	1016	20	type	type	NN
cord-264884-ydkigome	1016	21	1	1	CD
cord-264884-ydkigome	1016	22	in	in	IN
cord-264884-ydkigome	1016	23	the	the	DT
cord-264884-ydkigome	1016	24	evolution	evolution	NN
cord-264884-ydkigome	1016	25	of	of	IN
cord-264884-ydkigome	1016	26	viral	viral	JJ
cord-264884-ydkigome	1016	27	resistance	resistance	NN
cord-264884-ydkigome	1016	28	to	to	IN
cord-264884-ydkigome	1016	29	protease	protease	NN
cord-264884-ydkigome	1016	30	inhibitors	inhibitor	NNS
cord-264884-ydkigome	1016	31	Extensive	extensive	JJ
cord-264884-ydkigome	1016	32	recombination	recombination	NN
cord-264884-ydkigome	1016	33	among	among	IN
cord-264884-ydkigome	1016	34	human	human	JJ
cord-264884-ydkigome	1016	35	immunodefi	immunodefi	NNP
cord-264884-ydkigome	1016	36	ciency	ciency	NNP
cord-264884-ydkigome	1016	37	virus	virus	NNP
cord-264884-ydkigome	1016	38	type	type	NN
cord-264884-ydkigome	1016	39	1	1	CD
cord-264884-ydkigome	1016	40	quasispecies	quasispecie	NNS
cord-264884-ydkigome	1016	41	makes	make	VBZ
cord-264884-ydkigome	1016	42	an	an	DT
cord-264884-ydkigome	1016	43	important	important	JJ
cord-264884-ydkigome	1016	44	contribution	contribution	NN
cord-264884-ydkigome	1016	45	to	to	IN
cord-264884-ydkigome	1016	46	viral	viral	JJ
cord-264884-ydkigome	1016	47	diversity	diversity	NN
cord-264884-ydkigome	1016	48	in	in	IN
cord-264884-ydkigome	1016	49	individual	individual	JJ
cord-264884-ydkigome	1016	50	patients	patient	NNS
cord-264884-ydkigome	1016	51	Evolutionary	evolutionary	JJ
cord-264884-ydkigome	1016	52	relationships	relationship	NNS
cord-264884-ydkigome	1016	53	among	among	IN
cord-264884-ydkigome	1016	54	large	large	JJ
cord-264884-ydkigome	1016	55	double	double	RB
cord-264884-ydkigome	1016	56	-	-	HYPH
cord-264884-ydkigome	1016	57	stranded	strand	VBN
cord-264884-ydkigome	1016	58	DNA	dna	NN
cord-264884-ydkigome	1016	59	viruses	virus	NNS
cord-264884-ydkigome	1016	60	that	that	WDT
cord-264884-ydkigome	1016	61	infect	infect	VBP
cord-264884-ydkigome	1016	62	microalgae	microalgae	NN
cord-264884-ydkigome	1016	63	and	and	CC
cord-264884-ydkigome	1016	64	other	other	JJ
cord-264884-ydkigome	1016	65	organisms	organism	NNS
cord-264884-ydkigome	1016	66	as	as	IN
cord-264884-ydkigome	1016	67	inferred	infer	VBN
cord-264884-ydkigome	1016	68	from	from	IN
cord-264884-ydkigome	1016	69	DNA	dna	NN
cord-264884-ydkigome	1016	70	polymerase	polymerase	NN
cord-264884-ydkigome	1016	71	genes	gene	NNS
cord-264884-ydkigome	1017	1	The	the	DT
cord-264884-ydkigome	1017	2	thymidylate	thymidylate	NN
cord-264884-ydkigome	1017	3	synthase	synthase	NN
cord-264884-ydkigome	1017	4	gene	gene	NN
cord-264884-ydkigome	1017	5	of	of	IN
cord-264884-ydkigome	1017	6	Hz-1	Hz-1	NNP
cord-264884-ydkigome	1017	7	virus	virus	NN
cord-264884-ydkigome	1017	8	:	:	:
cord-264884-ydkigome	1017	9	a	a	DT
cord-264884-ydkigome	1017	10	gene	gene	NN
cord-264884-ydkigome	1017	11	captured	capture	VBN
cord-264884-ydkigome	1017	12	from	from	IN
cord-264884-ydkigome	1017	13	its	-PRON-	PRP$
cord-264884-ydkigome	1017	14	lepidopteran	lepidopteran	JJ
cord-264884-ydkigome	1017	15	host	host	NN
cord-264884-ydkigome	1017	16	Mapping	mapping	NN
cord-264884-ydkigome	1017	17	of	of	IN
cord-264884-ydkigome	1017	18	mutations	mutation	NNS
cord-264884-ydkigome	1017	19	associated	associate	VBN
cord-264884-ydkigome	1017	20	with	with	IN
cord-264884-ydkigome	1017	21	neurovirulence	neurovirulence	NNP
cord-264884-ydkigome	1017	22	in	in	IN
cord-264884-ydkigome	1017	23	monkeys	monkey	NNS
cord-264884-ydkigome	1017	24	infected	infect	VBN
cord-264884-ydkigome	1017	25	with	with	IN
cord-264884-ydkigome	1017	26	Sabin	Sabin	NNP
cord-264884-ydkigome	1017	27	1	1	CD
cord-264884-ydkigome	1017	28	poliovirus	poliovirus	NN
cord-264884-ydkigome	1017	29	revertants	revertant	NNS
cord-264884-ydkigome	1017	30	selected	select	VBN
cord-264884-ydkigome	1017	31	at	at	IN
cord-264884-ydkigome	1017	32	high	high	JJ
cord-264884-ydkigome	1017	33	temperature	temperature	NN
cord-264884-ydkigome	1018	1	The	the	DT
cord-264884-ydkigome	1018	2	red	red	JJ
cord-264884-ydkigome	1018	3	queen	queen	NN
cord-264884-ydkigome	1018	4	reigns	reign	VBZ
cord-264884-ydkigome	1018	5	in	in	IN
cord-264884-ydkigome	1018	6	the	the	DT
cord-264884-ydkigome	1018	7	kingdom	kingdom	NN
cord-264884-ydkigome	1018	8	of	of	IN
cord-264884-ydkigome	1018	9	RNA	RNA	NNP
cord-264884-ydkigome	1018	10	viruses	virus	NNS
cord-264884-ydkigome	1018	11	Mimivirus	Mimivirus	NNP
cord-264884-ydkigome	1018	12	and	and	CC
cord-264884-ydkigome	1018	13	the	the	DT
cord-264884-ydkigome	1018	14	emerging	emerge	VBG
cord-264884-ydkigome	1018	15	concept	concept	NN
cord-264884-ydkigome	1018	16	of	of	IN
cord-264884-ydkigome	1018	17	"	"	``
cord-264884-ydkigome	1018	18	giant	giant	JJ
cord-264884-ydkigome	1018	19	"	"	''
cord-264884-ydkigome	1018	20	virus	virus	NN
cord-264884-ydkigome	1018	21	Transcription	transcription	NN
cord-264884-ydkigome	1018	22	of	of	IN
cord-264884-ydkigome	1018	23	a	a	DT
cord-264884-ydkigome	1018	24	'	'	``
cord-264884-ydkigome	1018	25	photosynthetic	photosynthetic	JJ
cord-264884-ydkigome	1018	26	'	'	''
cord-264884-ydkigome	1018	27	T4-type	t4-type	CD
cord-264884-ydkigome	1018	28	phage	phage	NN
cord-264884-ydkigome	1018	29	during	during	IN
cord-264884-ydkigome	1018	30	infection	infection	NN
cord-264884-ydkigome	1018	31	of	of	IN
cord-264884-ydkigome	1018	32	a	a	DT
cord-264884-ydkigome	1018	33	marine	marine	JJ
cord-264884-ydkigome	1018	34	cyanobacterium	cyanobacterium	NN
cord-264884-ydkigome	1018	35	Genomic	Genomic	NNP
cord-264884-ydkigome	1018	36	islands	island	NNS
cord-264884-ydkigome	1018	37	and	and	CC
cord-264884-ydkigome	1018	38	the	the	DT
cord-264884-ydkigome	1018	39	ecology	ecology	NN
cord-264884-ydkigome	1018	40	and	and	CC
cord-264884-ydkigome	1018	41	evolution	evolution	NN
cord-264884-ydkigome	1018	42	of	of	IN
cord-264884-ydkigome	1018	43	Prochlorococcus	Prochlorococcus	NNP
cord-264884-ydkigome	1018	44	War	War	NNP
cord-264884-ydkigome	1019	1	is	be	VBZ
cord-264884-ydkigome	1019	2	peacedispatches	peacedispatche	NNS
cord-264884-ydkigome	1019	3	from	from	IN
cord-264884-ydkigome	1019	4	the	the	DT
cord-264884-ydkigome	1019	5	bacterial	bacterial	JJ
cord-264884-ydkigome	1019	6	and	and	CC
cord-264884-ydkigome	1019	7	phage	phage	NN
cord-264884-ydkigome	1020	1	killing	kill	VBG
cord-264884-ydkigome	1020	2	fi	fi	NNP
cord-264884-ydkigome	1020	3	elds	elds	NNP
cord-264884-ydkigome	1020	4	Genetic	genetic	JJ
cord-264884-ydkigome	1020	5	richness	richness	NN
cord-264884-ydkigome	1020	6	of	of	IN
cord-264884-ydkigome	1020	7	vibriophages	vibriophage	NNS
cord-264884-ydkigome	1020	8	isolated	isolate	VBN
cord-264884-ydkigome	1020	9	in	in	IN
cord-264884-ydkigome	1020	10	a	a	DT
cord-264884-ydkigome	1020	11	coastal	coastal	JJ
cord-264884-ydkigome	1020	12	environment	environment	NN
cord-264884-ydkigome	1020	13	Implications	implication	NNS
cord-264884-ydkigome	1020	14	of	of	IN
cord-264884-ydkigome	1020	15	high	high	JJ
cord-264884-ydkigome	1020	16	RNA	RNA	NNP
cord-264884-ydkigome	1020	17	virus	virus	NN
cord-264884-ydkigome	1020	18	mutation	mutation	NN
cord-264884-ydkigome	1020	19	rates	rate	NNS
cord-264884-ydkigome	1020	20	:	:	:
cord-264884-ydkigome	1020	21	lethal	lethal	JJ
cord-264884-ydkigome	1020	22	mutagenesis	mutagenesis	NN
cord-264884-ydkigome	1020	23	and	and	CC
cord-264884-ydkigome	1020	24	the	the	DT
cord-264884-ydkigome	1020	25	antiviral	antiviral	JJ
cord-264884-ydkigome	1020	26	drug	drug	NN
cord-264884-ydkigome	1021	1	ribavirin	ribavirin	NNP
cord-264884-ydkigome	1021	2	RNA	RNA	NNP
cord-264884-ydkigome	1021	3	virus	virus	NN
cord-264884-ydkigome	1021	4	error	error	NN
cord-264884-ydkigome	1021	5	catastrophe	catastrophe	NN
cord-264884-ydkigome	1021	6	:	:	:
cord-264884-ydkigome	1021	7	direct	direct	JJ
cord-264884-ydkigome	1021	8	molecular	molecular	JJ
cord-264884-ydkigome	1021	9	test	test	NN
cord-264884-ydkigome	1021	10	by	by	IN
cord-264884-ydkigome	1021	11	using	use	VBG
cord-264884-ydkigome	1021	12	ribavirin	ribavirin	JJ
cord-264884-ydkigome	1021	13	Poliovirus	Poliovirus	NNP
cord-264884-ydkigome	1021	14	pathogenesis	pathogenesis	NN
cord-264884-ydkigome	1021	15	in	in	IN
cord-264884-ydkigome	1021	16	a	a	DT
cord-264884-ydkigome	1021	17	new	new	JJ
cord-264884-ydkigome	1021	18	poliovirus	poliovirus	NN
cord-264884-ydkigome	1021	19	receptor	receptor	NN
cord-264884-ydkigome	1021	20	transgenic	transgenic	JJ
cord-264884-ydkigome	1021	21	mouse	mouse	NN
cord-264884-ydkigome	1021	22	model	model	NN
cord-264884-ydkigome	1021	23	:	:	:
cord-264884-ydkigome	1021	24	age	age	NN
cord-264884-ydkigome	1021	25	-	-	HYPH
cord-264884-ydkigome	1021	26	dependent	dependent	JJ
cord-264884-ydkigome	1021	27	paralysis	paralysis	NN
cord-264884-ydkigome	1021	28	and	and	CC
cord-264884-ydkigome	1021	29	a	a	DT
cord-264884-ydkigome	1021	30	mucosal	mucosal	JJ
cord-264884-ydkigome	1021	31	route	route	NN
cord-264884-ydkigome	1021	32	of	of	IN
cord-264884-ydkigome	1021	33	infection	infection	NN
cord-264884-ydkigome	1021	34	Trans	trans	JJ
cord-264884-ydkigome	1021	35	-	-	JJ
cord-264884-ydkigome	1021	36	dominant	dominant	JJ
cord-264884-ydkigome	1021	37	inhibition	inhibition	NN
cord-264884-ydkigome	1021	38	of	of	IN
cord-264884-ydkigome	1021	39	RNA	RNA	NNP
cord-264884-ydkigome	1021	40	viral	viral	JJ
cord-264884-ydkigome	1021	41	replication	replication	NN
cord-264884-ydkigome	1021	42	can	can	MD
cord-264884-ydkigome	1021	43	slow	slow	VB
cord-264884-ydkigome	1021	44	growth	growth	NN
cord-264884-ydkigome	1021	45	of	of	IN
cord-264884-ydkigome	1021	46	drug	drug	NN
cord-264884-ydkigome	1021	47	-	-	HYPH
cord-264884-ydkigome	1021	48	resistant	resistant	JJ
cord-264884-ydkigome	1021	49	viruses	virus	NNS
cord-264884-ydkigome	1022	1	New	new	JJ
cord-264884-ydkigome	1022	2	genes	gene	NNS
cord-264884-ydkigome	1022	3	from	from	IN
cord-264884-ydkigome	1022	4	old	old	JJ
cord-264884-ydkigome	1022	5	:	:	:
cord-264884-ydkigome	1022	6	redeployment	redeployment	NN
cord-264884-ydkigome	1022	7	of	of	IN
cord-264884-ydkigome	1022	8	dUTPase	dUTPase	NNP
cord-264884-ydkigome	1022	9	by	by	IN
cord-264884-ydkigome	1022	10	herpesviruses	herpesviruses	NNP
cord-264884-ydkigome	1023	1	The	the	DT
cord-264884-ydkigome	1023	2	human	human	JJ
cord-264884-ydkigome	1023	3	cytomegalovirus	cytomegalovirus	NN
cord-264884-ydkigome	1023	4	genome	genome	NN
cord-264884-ydkigome	1023	5	revisited	revisit	VBD
cord-264884-ydkigome	1023	6	:	:	:
cord-264884-ydkigome	1023	7	comparison	comparison	NN
cord-264884-ydkigome	1023	8	with	with	IN
cord-264884-ydkigome	1023	9	the	the	DT
cord-264884-ydkigome	1023	10	chimpanzee	chimpanzee	NN
cord-264884-ydkigome	1023	11	cytomegalovirus	cytomegalovirus	NN
cord-264884-ydkigome	1023	12	genome	genome	NN
cord-264884-ydkigome	1023	13	A	a	DT
cord-264884-ydkigome	1023	14	novel	novel	JJ
cord-264884-ydkigome	1023	15	class	class	NN
cord-264884-ydkigome	1023	16	of	of	IN
cord-264884-ydkigome	1023	17	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	1023	18	with	with	IN
cord-264884-ydkigome	1023	19	bivalve	bivalve	JJ
cord-264884-ydkigome	1023	20	hosts	host	NNS
cord-264884-ydkigome	1024	1	The	the	DT
cord-264884-ydkigome	1024	2	complete	complete	JJ
cord-264884-ydkigome	1024	3	DNA	dna	NN
cord-264884-ydkigome	1024	4	sequence	sequence	NN
cord-264884-ydkigome	1024	5	of	of	IN
cord-264884-ydkigome	1024	6	the	the	DT
cord-264884-ydkigome	1024	7	Ectocarpus	Ectocarpus	NNP
cord-264884-ydkigome	1024	8	siliculosus	siliculosus	XX
cord-264884-ydkigome	1025	1	Virus	Virus	NNP
cord-264884-ydkigome	1025	2	EsV-1	EsV-1	NNP
cord-264884-ydkigome	1025	3	genome	genome	NN
cord-264884-ydkigome	1025	4	Comparisons	comparison	NNS
cord-264884-ydkigome	1025	5	of	of	IN
cord-264884-ydkigome	1025	6	two	two	CD
cord-264884-ydkigome	1025	7	large	large	JJ
cord-264884-ydkigome	1025	8	phaeoviral	phaeoviral	JJ
cord-264884-ydkigome	1025	9	genomes	genome	NNS
cord-264884-ydkigome	1025	10	and	and	CC
cord-264884-ydkigome	1025	11	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1025	12	implications	implication	NNS
cord-264884-ydkigome	1025	13	Interference	interference	NN
cord-264884-ydkigome	1025	14	between	between	IN
cord-264884-ydkigome	1025	15	bacterial	bacterial	JJ
cord-264884-ydkigome	1025	16	viruses	virus	NNS
cord-264884-ydkigome	1025	17	:	:	:
cord-264884-ydkigome	1025	18	III	III	NNP
cord-264884-ydkigome	1025	19	.	.	.
cord-264884-ydkigome	1026	1	The	the	DT
cord-264884-ydkigome	1026	2	mutual	mutual	JJ
cord-264884-ydkigome	1026	3	exclusion	exclusion	NN
cord-264884-ydkigome	1026	4	effect	effect	NN
cord-264884-ydkigome	1026	5	and	and	CC
cord-264884-ydkigome	1026	6	the	the	DT
cord-264884-ydkigome	1026	7	depressor	depressor	NN
cord-264884-ydkigome	1026	8	effect	effect	NN
cord-264884-ydkigome	1026	9	Restriction	restriction	NN
cord-264884-ydkigome	1026	10	of	of	IN
cord-264884-ydkigome	1026	11	foamy	foamy	NN
cord-264884-ydkigome	1026	12	viruses	virus	NNS
cord-264884-ydkigome	1026	13	by	by	IN
cord-264884-ydkigome	1026	14	APOBEC	APOBEC	NNP
cord-264884-ydkigome	1026	15	cytidine	cytidine	NNP
cord-264884-ydkigome	1027	1	deaminases	deaminases	NNP
cord-264884-ydkigome	1027	2	Serologic	Serologic	NNP
cord-264884-ydkigome	1027	3	study	study	NN
cord-264884-ydkigome	1027	4	on	on	IN
cord-264884-ydkigome	1027	5	the	the	DT
cord-264884-ydkigome	1027	6	prevalence	prevalence	NN
cord-264884-ydkigome	1027	7	of	of	IN
cord-264884-ydkigome	1027	8	murine	murine	JJ
cord-264884-ydkigome	1027	9	viruses	virus	NNS
cord-264884-ydkigome	1027	10	in	in	IN
cord-264884-ydkigome	1027	11	a	a	DT
cord-264884-ydkigome	1027	12	population	population	NN
cord-264884-ydkigome	1027	13	of	of	IN
cord-264884-ydkigome	1027	14	wild	wild	JJ
cord-264884-ydkigome	1027	15	meadow	meadow	NN
cord-264884-ydkigome	1027	16	voles	vole	NNS
cord-264884-ydkigome	1027	17	(	(	-LRB-
cord-264884-ydkigome	1027	18	Microtus	Microtus	NNP
cord-264884-ydkigome	1027	19	pennsylvanicus	pennsylvanicus	NNP
cord-264884-ydkigome	1027	20	)	)	-RRB-
cord-264884-ydkigome	1028	1	Serologic	Serologic	NNP
cord-264884-ydkigome	1028	2	study	study	NN
cord-264884-ydkigome	1028	3	on	on	IN
cord-264884-ydkigome	1028	4	the	the	DT
cord-264884-ydkigome	1028	5	prevalence	prevalence	NN
cord-264884-ydkigome	1028	6	of	of	IN
cord-264884-ydkigome	1028	7	murine	murine	JJ
cord-264884-ydkigome	1028	8	viruses	virus	NNS
cord-264884-ydkigome	1028	9	in	in	IN
cord-264884-ydkigome	1028	10	fi	fi	NNP
cord-264884-ydkigome	1028	11	ve	ve	VBD
cord-264884-ydkigome	1028	12	Canadian	canadian	JJ
cord-264884-ydkigome	1028	13	mouse	mouse	NN
cord-264884-ydkigome	1028	14	colonies	colony	NNS
cord-264884-ydkigome	1029	1	New	new	JJ
cord-264884-ydkigome	1029	2	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1029	3	frontiers	frontier	NNS
cord-264884-ydkigome	1029	4	from	from	IN
cord-264884-ydkigome	1029	5	unusual	unusual	JJ
cord-264884-ydkigome	1029	6	virus	virus	NN
cord-264884-ydkigome	1029	7	genomes	genome	NNS
cord-264884-ydkigome	1029	8	Quasispecies	Quasispecies	NNPS
cord-264884-ydkigome	1029	9	and	and	CC
cord-264884-ydkigome	1029	10	RNA	RNA	NNP
cord-264884-ydkigome	1029	11	Virus	Virus	NNP
cord-264884-ydkigome	1029	12	Evolution	Evolution	NNP
cord-264884-ydkigome	1029	13	:	:	:
cord-264884-ydkigome	1030	1	Principles	principle	NNS
cord-264884-ydkigome	1030	2	and	and	CC
cord-264884-ydkigome	1030	3	Consequences	Consequences	NNPS
cord-264884-ydkigome	1030	4	Quasispecies	Quasispecies	NNPS
cord-264884-ydkigome	1030	5	:	:	:
cord-264884-ydkigome	1030	6	concept	concept	NN
cord-264884-ydkigome	1030	7	and	and	CC
cord-264884-ydkigome	1030	8	implications	implication	NNS
cord-264884-ydkigome	1030	9	for	for	IN
cord-264884-ydkigome	1030	10	virology	virology	NN
cord-264884-ydkigome	1030	11	Quasispecies	Quasispecies	NNPS
cord-264884-ydkigome	1030	12	and	and	CC
cord-264884-ydkigome	1030	13	its	-PRON-	PRP$
cord-264884-ydkigome	1030	14	impact	impact	NN
cord-264884-ydkigome	1030	15	on	on	IN
cord-264884-ydkigome	1030	16	viral	viral	JJ
cord-264884-ydkigome	1030	17	hepatitis	hepatitis	NN
cord-264884-ydkigome	1030	18	Nucleotide	Nucleotide	NNP
cord-264884-ydkigome	1030	19	sequence	sequence	NN
cord-264884-ydkigome	1030	20	heterogeneity	heterogeneity	NN
cord-264884-ydkigome	1030	21	of	of	IN
cord-264884-ydkigome	1030	22	an	an	DT
cord-264884-ydkigome	1030	23	RNA	RNA	NNP
cord-264884-ydkigome	1030	24	phage	phage	NN
cord-264884-ydkigome	1030	25	population	population	NN
cord-264884-ydkigome	1030	26	Origin	Origin	NNP
cord-264884-ydkigome	1030	27	and	and	CC
cord-264884-ydkigome	1030	28	Evolution	Evolution	NNP
cord-264884-ydkigome	1030	29	of	of	IN
cord-264884-ydkigome	1030	30	Viruses	virus	NNS
cord-264884-ydkigome	1031	1	Selfi	Selfi	NNP
cord-264884-ydkigome	1031	2	sh	sh	NN
cord-264884-ydkigome	1031	3	genes	gene	NNS
cord-264884-ydkigome	1031	4	,	,	,
cord-264884-ydkigome	1031	5	the	the	DT
cord-264884-ydkigome	1031	6	phenotype	phenotype	NN
cord-264884-ydkigome	1031	7	paradigm	paradigm	NN
cord-264884-ydkigome	1031	8	and	and	CC
cord-264884-ydkigome	1031	9	genome	genome	NN
cord-264884-ydkigome	1031	10	evolution	evolution	NN
cord-264884-ydkigome	1031	11	Asymmetric	Asymmetric	NNP
cord-264884-ydkigome	1031	12	DDE	DDE	NNP
cord-264884-ydkigome	1031	13	(	(	-LRB-
cord-264884-ydkigome	1031	14	D35E)-like	d35e)-like	IN
cord-264884-ydkigome	1031	15	sequences	sequence	NNS
cord-264884-ydkigome	1031	16	in	in	IN
cord-264884-ydkigome	1031	17	the	the	DT
cord-264884-ydkigome	1031	18	RAG	rag	NN
cord-264884-ydkigome	1031	19	proteins	protein	NNS
cord-264884-ydkigome	1031	20	:	:	:
cord-264884-ydkigome	1031	21	implications	implication	NNS
cord-264884-ydkigome	1031	22	for	for	IN
cord-264884-ydkigome	1031	23	V(D)J	V(D)J	NNP
cord-264884-ydkigome	1031	24	recombination	recombination	NN
cord-264884-ydkigome	1031	25	and	and	CC
cord-264884-ydkigome	1031	26	retroviral	retroviral	JJ
cord-264884-ydkigome	1031	27	pathogenesis	pathogenesis	NN
cord-264884-ydkigome	1031	28	Shared	share	VBN
cord-264884-ydkigome	1031	29	architecture	architecture	NN
cord-264884-ydkigome	1031	30	of	of	IN
cord-264884-ydkigome	1031	31	bacteriophage	bacteriophage	NN
cord-264884-ydkigome	1031	32	SP01	SP01	NNP
cord-264884-ydkigome	1031	33	and	and	CC
cord-264884-ydkigome	1031	34	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	1031	35	capsids	capsid	VBZ
cord-264884-ydkigome	1031	36	a	a	DT
cord-264884-ydkigome	1031	37	)	)	-RRB-
cord-264884-ydkigome	1031	38	Ovine	ovine	JJ
cord-264884-ydkigome	1031	39	endogenous	endogenous	JJ
cord-264884-ydkigome	1031	40	betaretroviruses	betaretroviruse	NNS
cord-264884-ydkigome	1031	41	(	(	-LRB-
cord-264884-ydkigome	1031	42	enJSRVs	enJSRVs	NNP
cord-264884-ydkigome	1031	43	)	)	-RRB-
cord-264884-ydkigome	1031	44	and	and	CC
cord-264884-ydkigome	1031	45	placental	placental	JJ
cord-264884-ydkigome	1031	46	morphogenesis	morphogenesis	NN
cord-264884-ydkigome	1031	47	b	b	NN
cord-264884-ydkigome	1031	48	)	)	-RRB-
cord-264884-ydkigome	1032	1	Endogenous	endogenous	JJ
cord-264884-ydkigome	1032	2	retroviruses	retrovirus	NNS
cord-264884-ydkigome	1032	3	regulate	regulate	VBP
cord-264884-ydkigome	1032	4	periimplantation	periimplantation	NN
cord-264884-ydkigome	1032	5	placental	placental	NN
cord-264884-ydkigome	1032	6	growth	growth	NN
cord-264884-ydkigome	1032	7	and	and	CC
cord-264884-ydkigome	1032	8	differentiation	differentiation	NN
cord-264884-ydkigome	1033	1	Syncytin	Syncytin	NNP
cord-264884-ydkigome	1033	2	-	-	HYPH
cord-264884-ydkigome	1033	3	A	A	NNP
cord-264884-ydkigome	1033	4	and	and	CC
cord-264884-ydkigome	1033	5	syncytin	syncytin	NN
cord-264884-ydkigome	1033	6	-	-	HYPH
cord-264884-ydkigome	1033	7	B	b	NN
cord-264884-ydkigome	1033	8	,	,	,
cord-264884-ydkigome	1033	9	two	two	CD
cord-264884-ydkigome	1033	10	fusogenic	fusogenic	JJ
cord-264884-ydkigome	1033	11	placentaspecifi	placentaspecifi	NNP
cord-264884-ydkigome	1033	12	c	c	NNP
cord-264884-ydkigome	1033	13	murine	murine	NN
cord-264884-ydkigome	1033	14	envelope	envelope	NN
cord-264884-ydkigome	1033	15	genes	gene	NNS
cord-264884-ydkigome	1033	16	of	of	IN
cord-264884-ydkigome	1033	17	retroviral	retroviral	JJ
cord-264884-ydkigome	1033	18	origin	origin	NN
cord-264884-ydkigome	1033	19	conserved	conserve	VBN
cord-264884-ydkigome	1033	20	in	in	IN
cord-264884-ydkigome	1033	21	Muridae	Muridae	NNP
cord-264884-ydkigome	1033	22	Viral	Viral	NNP
cord-264884-ydkigome	1033	23	metagenomics	metagenomic	NNS
cord-264884-ydkigome	1034	1	Molecular	molecular	JJ
cord-264884-ydkigome	1034	2	quasi	quasi	JJ
cord-264884-ydkigome	1034	3	-	-	HYPH
cord-264884-ydkigome	1034	4	species	species	JJ
cord-264884-ydkigome	1034	5	Genetic	genetic	JJ
cord-264884-ydkigome	1034	6	stability	stability	NN
cord-264884-ydkigome	1034	7	of	of	IN
cord-264884-ydkigome	1034	8	the	the	DT
cord-264884-ydkigome	1034	9	VHSV	VHSV	NNP
cord-264884-ydkigome	1034	10	consensus	consensus	NN
cord-264884-ydkigome	1034	11	sequence	sequence	NN
cord-264884-ydkigome	1034	12	of	of	IN
cord-264884-ydkigome	1034	13	G	g	NN
cord-264884-ydkigome	1034	14	-	-	HYPH
cord-264884-ydkigome	1034	15	gene	gene	NN
cord-264884-ydkigome	1034	16	in	in	IN
cord-264884-ydkigome	1034	17	diagnostic	diagnostic	JJ
cord-264884-ydkigome	1034	18	samples	sample	NNS
cord-264884-ydkigome	1034	19	from	from	IN
cord-264884-ydkigome	1034	20	an	an	DT
cord-264884-ydkigome	1034	21	acute	acute	JJ
cord-264884-ydkigome	1034	22	outbreak	outbreak	NN
cord-264884-ydkigome	1034	23	Evolution	evolution	NN
cord-264884-ydkigome	1034	24	of	of	IN
cord-264884-ydkigome	1034	25	fi	fi	NN
cord-264884-ydkigome	1034	26	tness	tness	NN
cord-264884-ydkigome	1034	27	in	in	IN
cord-264884-ydkigome	1034	28	experimental	experimental	JJ
cord-264884-ydkigome	1034	29	populations	population	NNS
cord-264884-ydkigome	1034	30	of	of	IN
cord-264884-ydkigome	1034	31	vesicular	vesicular	JJ
cord-264884-ydkigome	1034	32	stomatitis	stomatitis	NN
cord-264884-ydkigome	1034	33	virus	virus	NN
cord-264884-ydkigome	1034	34	Fluctuation	fluctuation	NN
cord-264884-ydkigome	1034	35	of	of	IN
cord-264884-ydkigome	1034	36	hepatitis	hepatitis	NN
cord-264884-ydkigome	1034	37	C	C	NNP
cord-264884-ydkigome	1034	38	virus	virus	NN
cord-264884-ydkigome	1034	39	quasispecies	quasispecie	VBZ
cord-264884-ydkigome	1034	40	in	in	IN
cord-264884-ydkigome	1034	41	persistent	persistent	JJ
cord-264884-ydkigome	1034	42	infection	infection	NN
cord-264884-ydkigome	1034	43	and	and	CC
cord-264884-ydkigome	1034	44	interferon	interferon	NN
cord-264884-ydkigome	1034	45	treatment	treatment	NN
cord-264884-ydkigome	1034	46	revealed	reveal	VBN
cord-264884-ydkigome	1034	47	by	by	IN
cord-264884-ydkigome	1034	48	single	single	JJ
cord-264884-ydkigome	1034	49	-	-	HYPH
cord-264884-ydkigome	1034	50	strand	strand	NN
cord-264884-ydkigome	1034	51	conformation	conformation	NN
cord-264884-ydkigome	1034	52	polymorphism	polymorphism	NN
cord-264884-ydkigome	1034	53	analysis	analysis	NN
cord-264884-ydkigome	1035	1	APOBEC3	APOBEC3	NNP
cord-264884-ydkigome	1036	1	G	g	NN
cord-264884-ydkigome	1036	2	cytidine	cytidine	NN
cord-264884-ydkigome	1036	3	deaminase	deaminase	NN
cord-264884-ydkigome	1036	4	inhibits	inhibit	VBZ
cord-264884-ydkigome	1036	5	retrotransposition	retrotransposition	NN
cord-264884-ydkigome	1036	6	of	of	IN
cord-264884-ydkigome	1036	7	endogenous	endogenous	JJ
cord-264884-ydkigome	1036	8	retroviruses	retrovirus	NNS
cord-264884-ydkigome	1036	9	Molecular	molecular	JJ
cord-264884-ydkigome	1036	10	ecology	ecology	NN
cord-264884-ydkigome	1036	11	and	and	CC
cord-264884-ydkigome	1036	12	emergence	emergence	NN
cord-264884-ydkigome	1036	13	of	of	IN
cord-264884-ydkigome	1036	14	tropical	tropical	JJ
cord-264884-ydkigome	1036	15	plant	plant	NN
cord-264884-ydkigome	1036	16	viruses	virus	NNS
cord-264884-ydkigome	1037	1	The	the	DT
cord-264884-ydkigome	1037	2	effect	effect	NN
cord-264884-ydkigome	1037	3	of	of	IN
cord-264884-ydkigome	1037	4	cowpox	cowpox	NN
cord-264884-ydkigome	1037	5	virus	virus	NN
cord-264884-ydkigome	1037	6	infection	infection	NN
cord-264884-ydkigome	1037	7	on	on	IN
cord-264884-ydkigome	1037	8	fecundity	fecundity	NN
cord-264884-ydkigome	1037	9	in	in	IN
cord-264884-ydkigome	1037	10	bank	bank	NN
cord-264884-ydkigome	1037	11	voles	vole	NNS
cord-264884-ydkigome	1037	12	and	and	CC
cord-264884-ydkigome	1037	13	wood	wood	NN
cord-264884-ydkigome	1037	14	mice	mouse	NNS
cord-264884-ydkigome	1038	1	Transspecies	transspecie	NNS
cord-264884-ydkigome	1038	2	transmission	transmission	NN
cord-264884-ydkigome	1038	3	of	of	IN
cord-264884-ydkigome	1038	4	the	the	DT
cord-264884-ydkigome	1038	5	endogenous	endogenous	JJ
cord-264884-ydkigome	1038	6	koala	koala	NN
cord-264884-ydkigome	1038	7	retrovirus	retrovirus	NN
cord-264884-ydkigome	1039	1	The	the	DT
cord-264884-ydkigome	1039	2	role	role	NN
cord-264884-ydkigome	1039	3	played	play	VBN
cord-264884-ydkigome	1039	4	by	by	IN
cord-264884-ydkigome	1039	5	viruses	virus	NNS
cord-264884-ydkigome	1039	6	in	in	IN
cord-264884-ydkigome	1039	7	the	the	DT
cord-264884-ydkigome	1039	8	evolution	evolution	NN
cord-264884-ydkigome	1039	9	of	of	IN
cord-264884-ydkigome	1039	10	their	-PRON-	PRP$
cord-264884-ydkigome	1039	11	hosts	host	NNS
cord-264884-ydkigome	1039	12	:	:	:
cord-264884-ydkigome	1039	13	a	a	DT
cord-264884-ydkigome	1039	14	view	view	NN
cord-264884-ydkigome	1039	15	based	base	VBN
cord-264884-ydkigome	1039	16	on	on	IN
cord-264884-ydkigome	1040	1	informational	informational	JJ
cord-264884-ydkigome	1040	2	protein	protein	NN
cord-264884-ydkigome	1040	3	phylogenies	phylogeny	NNS
cord-264884-ydkigome	1040	4	Marine	Marine	NNP
cord-264884-ydkigome	1040	5	T4-type	T4-type	NNS
cord-264884-ydkigome	1040	6	bacteriophages	bacteriophage	NNS
cord-264884-ydkigome	1040	7	,	,	,
cord-264884-ydkigome	1040	8	a	a	DT
cord-264884-ydkigome	1040	9	ubiquitous	ubiquitous	JJ
cord-264884-ydkigome	1040	10	component	component	NN
cord-264884-ydkigome	1040	11	of	of	IN
cord-264884-ydkigome	1040	12	the	the	DT
cord-264884-ydkigome	1040	13	dark	dark	JJ
cord-264884-ydkigome	1040	14	matter	matter	NN
cord-264884-ydkigome	1040	15	of	of	IN
cord-264884-ydkigome	1040	16	the	the	DT
cord-264884-ydkigome	1040	17	biosphere	biosphere	NN
cord-264884-ydkigome	1040	18	a	a	DT
cord-264884-ydkigome	1040	19	)	)	-RRB-
cord-264884-ydkigome	1041	1	A	a	DT
cord-264884-ydkigome	1041	2	selective	selective	JJ
cord-264884-ydkigome	1041	3	barrier	barrier	NN
cord-264884-ydkigome	1041	4	to	to	IN
cord-264884-ydkigome	1041	5	horizontal	horizontal	JJ
cord-264884-ydkigome	1041	6	gene	gene	NN
cord-264884-ydkigome	1041	7	transfer	transfer	NN
cord-264884-ydkigome	1041	8	in	in	IN
cord-264884-ydkigome	1041	9	the	the	DT
cord-264884-ydkigome	1041	10	T4-type	t4-type	CD
cord-264884-ydkigome	1041	11	bacteriophages	bacteriophage	NNS
cord-264884-ydkigome	1041	12	that	that	WDT
cord-264884-ydkigome	1041	13	has	have	VBZ
cord-264884-ydkigome	1041	14	preserved	preserve	VBN
cord-264884-ydkigome	1041	15	a	a	DT
cord-264884-ydkigome	1041	16	core	core	NN
cord-264884-ydkigome	1041	17	genome	genome	NN
cord-264884-ydkigome	1041	18	with	with	IN
cord-264884-ydkigome	1041	19	the	the	DT
cord-264884-ydkigome	1041	20	viral	viral	JJ
cord-264884-ydkigome	1041	21	replication	replication	NN
cord-264884-ydkigome	1041	22	and	and	CC
cord-264884-ydkigome	1041	23	structural	structural	JJ
cord-264884-ydkigome	1041	24	genes	gene	NNS
cord-264884-ydkigome	1042	1	b	b	LS
cord-264884-ydkigome	1042	2	)	)	-RRB-
cord-264884-ydkigome	1043	1	T4-type	T4-type	NNP
cord-264884-ydkigome	1043	2	bacteriophages	bacteriophage	NNS
cord-264884-ydkigome	1043	3	:	:	:
cord-264884-ydkigome	1043	4	ubiquitous	ubiquitous	JJ
cord-264884-ydkigome	1043	5	components	component	NNS
cord-264884-ydkigome	1043	6	of	of	IN
cord-264884-ydkigome	1043	7	the	the	DT
cord-264884-ydkigome	1043	8	"	"	``
cord-264884-ydkigome	1043	9	dark	dark	JJ
cord-264884-ydkigome	1043	10	matter	matter	NN
cord-264884-ydkigome	1043	11	"	"	''
cord-264884-ydkigome	1043	12	of	of	IN
cord-264884-ydkigome	1043	13	the	the	DT
cord-264884-ydkigome	1043	14	biosphere	biosphere	NN
cord-264884-ydkigome	1043	15	c	c	NN
cord-264884-ydkigome	1043	16	)	)	-RRB-
cord-264884-ydkigome	1044	1	I	-PRON-	PRP
cord-264884-ydkigome	1044	2	am	be	VBP
cord-264884-ydkigome	1044	3	what	what	WP
cord-264884-ydkigome	1044	4	I	-PRON-	PRP
cord-264884-ydkigome	1044	5	eat	eat	VBP
cord-264884-ydkigome	1045	1	and	and	CC
cord-264884-ydkigome	1045	2	I	-PRON-	PRP
cord-264884-ydkigome	1045	3	eat	eat	VBP
cord-264884-ydkigome	1045	4	what	what	WP
cord-264884-ydkigome	1045	5	I	-PRON-	PRP
cord-264884-ydkigome	1045	6	am	be	VBP
cord-264884-ydkigome	1045	7	:	:	:
cord-264884-ydkigome	1045	8	acquisition	acquisition	NN
cord-264884-ydkigome	1045	9	of	of	IN
cord-264884-ydkigome	1045	10	bacterial	bacterial	JJ
cord-264884-ydkigome	1045	11	genes	gene	NNS
cord-264884-ydkigome	1045	12	by	by	IN
cord-264884-ydkigome	1045	13	giant	giant	JJ
cord-264884-ydkigome	1045	14	viruses	virus	NNS
cord-264884-ydkigome	1045	15	Female	female	JJ
cord-264884-ydkigome	1045	16	characteristics	characteristic	NNS
cord-264884-ydkigome	1045	17	in	in	IN
cord-264884-ydkigome	1045	18	the	the	DT
cord-264884-ydkigome	1045	19	Drosophila	Drosophila	NNP
cord-264884-ydkigome	1045	20	melanogaster	melanogaster	NN
cord-264884-ydkigome	1045	21	sigma	sigma	NN
cord-264884-ydkigome	1045	22	-	-	HYPH
cord-264884-ydkigome	1045	23	virus	virus	NN
cord-264884-ydkigome	1045	24	system	system	NN
cord-264884-ydkigome	1045	25	in	in	IN
cord-264884-ydkigome	1045	26	natural	natural	JJ
cord-264884-ydkigome	1045	27	-	-	HYPH
cord-264884-ydkigome	1045	28	populations	population	NNS
cord-264884-ydkigome	1045	29	from	from	IN
cord-264884-ydkigome	1045	30	Languedoc	Languedoc	NNP
cord-264884-ydkigome	1045	31	(	(	-LRB-
cord-264884-ydkigome	1045	32	Southern	Southern	NNP
cord-264884-ydkigome	1045	33	France	France	NNP
cord-264884-ydkigome	1045	34	)	)	-RRB-
cord-264884-ydkigome	1045	35	Polymorphism	polymorphism	NN
cord-264884-ydkigome	1045	36	of	of	IN
cord-264884-ydkigome	1045	37	the	the	DT
cord-264884-ydkigome	1045	38	Drosophila	Drosophila	NNP
cord-264884-ydkigome	1045	39	melanogaster	melanogaster	NN
cord-264884-ydkigome	1045	40	Sigma	Sigma	NNP
cord-264884-ydkigome	1045	41	virus	virus	NN
cord-264884-ydkigome	1045	42	system	system	NN
cord-264884-ydkigome	1045	43	Displacement	displacement	NN
cord-264884-ydkigome	1045	44	of	of	IN
cord-264884-ydkigome	1045	45	cellular	cellular	JJ
cord-264884-ydkigome	1045	46	proteins	protein	NNS
cord-264884-ydkigome	1045	47	by	by	IN
cord-264884-ydkigome	1045	48	functional	functional	JJ
cord-264884-ydkigome	1045	49	analogues	analogue	NNS
cord-264884-ydkigome	1045	50	from	from	IN
cord-264884-ydkigome	1045	51	plasmids	plasmid	NNS
cord-264884-ydkigome	1045	52	or	or	CC
cord-264884-ydkigome	1045	53	viruses	virus	NNS
cord-264884-ydkigome	1045	54	could	could	MD
cord-264884-ydkigome	1045	55	explain	explain	VB
cord-264884-ydkigome	1045	56	puzzling	puzzle	VBG
cord-264884-ydkigome	1045	57	phylogenies	phylogeny	NNS
cord-264884-ydkigome	1045	58	of	of	IN
cord-264884-ydkigome	1045	59	many	many	JJ
cord-264884-ydkigome	1045	60	DNA	dna	NN
cord-264884-ydkigome	1045	61	informational	informational	JJ
cord-264884-ydkigome	1045	62	proteins	protein	NNS
cord-264884-ydkigome	1046	1	The	the	DT
cord-264884-ydkigome	1046	2	great	great	JJ
cord-264884-ydkigome	1046	3	virus	virus	NN
cord-264884-ydkigome	1046	4	comeback	comeback	NN
cord-264884-ydkigome	1046	5	-	-	:
cord-264884-ydkigome	1046	6	from	from	IN
cord-264884-ydkigome	1046	7	an	an	DT
cord-264884-ydkigome	1046	8	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1046	9	perspective	perspective	NN
cord-264884-ydkigome	1047	1	The	the	DT
cord-264884-ydkigome	1047	2	two	two	CD
cord-264884-ydkigome	1047	3	ages	age	NNS
cord-264884-ydkigome	1047	4	of	of	IN
cord-264884-ydkigome	1047	5	the	the	DT
cord-264884-ydkigome	1047	6	RNA	RNA	NNP
cord-264884-ydkigome	1047	7	world	world	NN
cord-264884-ydkigome	1047	8	and	and	CC
cord-264884-ydkigome	1047	9	the	the	DT
cord-264884-ydkigome	1047	10	transition	transition	NN
cord-264884-ydkigome	1047	11	to	to	IN
cord-264884-ydkigome	1047	12	the	the	DT
cord-264884-ydkigome	1047	13	DNA	dna	NN
cord-264884-ydkigome	1047	14	world	world	NN
cord-264884-ydkigome	1047	15	:	:	:
cord-264884-ydkigome	1047	16	a	a	DT
cord-264884-ydkigome	1047	17	story	story	NN
cord-264884-ydkigome	1047	18	of	of	IN
cord-264884-ydkigome	1047	19	viruses	virus	NNS
cord-264884-ydkigome	1047	20	and	and	CC
cord-264884-ydkigome	1047	21	cells	cell	NNS
cord-264884-ydkigome	1047	22	a	a	LS
cord-264884-ydkigome	1047	23	)	)	-RRB-
cord-264884-ydkigome	1048	1	The	the	DT
cord-264884-ydkigome	1048	2	origin	origin	NN
cord-264884-ydkigome	1048	3	of	of	IN
cord-264884-ydkigome	1048	4	viruses	virus	NNS
cord-264884-ydkigome	1048	5	and	and	CC
cord-264884-ydkigome	1048	6	their	-PRON-	PRP$
cord-264884-ydkigome	1048	7	possible	possible	JJ
cord-264884-ydkigome	1048	8	roles	role	NNS
cord-264884-ydkigome	1048	9	in	in	IN
cord-264884-ydkigome	1048	10	major	major	JJ
cord-264884-ydkigome	1048	11	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1048	12	transitions	transition	NNS
cord-264884-ydkigome	1048	13	b	b	LS
cord-264884-ydkigome	1048	14	)	)	-RRB-
cord-264884-ydkigome	1049	1	Three	three	CD
cord-264884-ydkigome	1049	2	RNA	RNA	NNP
cord-264884-ydkigome	1049	3	cells	cell	NNS
cord-264884-ydkigome	1049	4	for	for	IN
cord-264884-ydkigome	1049	5	ribosomal	ribosomal	JJ
cord-264884-ydkigome	1049	6	lineages	lineage	NNS
cord-264884-ydkigome	1049	7	and	and	CC
cord-264884-ydkigome	1049	8	three	three	CD
cord-264884-ydkigome	1049	9	DNA	dna	NN
cord-264884-ydkigome	1049	10	viruses	virus	NNS
cord-264884-ydkigome	1050	1	to	to	TO
cord-264884-ydkigome	1050	2	replicate	replicate	VB
cord-264884-ydkigome	1050	3	their	-PRON-	PRP$
cord-264884-ydkigome	1050	4	genomes	genome	NNS
cord-264884-ydkigome	1050	5	:	:	:
cord-264884-ydkigome	1050	6	A	a	DT
cord-264884-ydkigome	1050	7	hypothesis	hypothesis	NN
cord-264884-ydkigome	1050	8	for	for	IN
cord-264884-ydkigome	1050	9	the	the	DT
cord-264884-ydkigome	1050	10	origin	origin	NN
cord-264884-ydkigome	1050	11	of	of	IN
cord-264884-ydkigome	1050	12	cellular	cellular	JJ
cord-264884-ydkigome	1050	13	domain	domain	NN
cord-264884-ydkigome	1050	14	Luca	Luca	NNP
cord-264884-ydkigome	1050	15	:	:	:
cord-264884-ydkigome	1050	16	the	the	DT
cord-264884-ydkigome	1050	17	last	last	JJ
cord-264884-ydkigome	1050	18	universal	universal	JJ
cord-264884-ydkigome	1050	19	common	common	JJ
cord-264884-ydkigome	1050	20	ancestor	ancestor	NN
cord-264884-ydkigome	1050	21	Origin	Origin	NNP
cord-264884-ydkigome	1050	22	and	and	CC
cord-264884-ydkigome	1050	23	evolution	evolution	NN
cord-264884-ydkigome	1050	24	of	of	IN
cord-264884-ydkigome	1050	25	DNA	dna	NN
cord-264884-ydkigome	1050	26	topoisomerases	topoisomerase	NNS
cord-264884-ydkigome	1050	27	Identifi	Identifi	NNP
cord-264884-ydkigome	1050	28	cation	cation	NN
cord-264884-ydkigome	1050	29	of	of	IN
cord-264884-ydkigome	1050	30	unique	unique	JJ
cord-264884-ydkigome	1050	31	hepatitis	hepatitis	NN
cord-264884-ydkigome	1050	32	C	C	NNP
cord-264884-ydkigome	1050	33	virus	virus	NN
cord-264884-ydkigome	1050	34	quasispecies	quasispecie	VBZ
cord-264884-ydkigome	1050	35	in	in	IN
cord-264884-ydkigome	1050	36	the	the	DT
cord-264884-ydkigome	1050	37	central	central	JJ
cord-264884-ydkigome	1050	38	nervous	nervous	JJ
cord-264884-ydkigome	1050	39	system	system	NN
cord-264884-ydkigome	1050	40	and	and	CC
cord-264884-ydkigome	1050	41	comparative	comparative	JJ
cord-264884-ydkigome	1050	42	analysis	analysis	NN
cord-264884-ydkigome	1050	43	of	of	IN
cord-264884-ydkigome	1050	44	internal	internal	JJ
cord-264884-ydkigome	1050	45	translational	translational	JJ
cord-264884-ydkigome	1050	46	effi	effi	NNP
cord-264884-ydkigome	1050	47	ciency	ciency	NNP
cord-264884-ydkigome	1050	48	of	of	IN
cord-264884-ydkigome	1050	49	brain	brain	NN
cord-264884-ydkigome	1050	50	,	,	,
cord-264884-ydkigome	1050	51	liver	liver	NN
cord-264884-ydkigome	1050	52	and	and	CC
cord-264884-ydkigome	1050	53	serum	serum	NN
cord-264884-ydkigome	1051	1	variants	variant	NNS
cord-264884-ydkigome	1052	1	Central	central	JJ
cord-264884-ydkigome	1052	2	nervous	nervous	JJ
cord-264884-ydkigome	1052	3	system	system	NN
cord-264884-ydkigome	1052	4	changes	change	NNS
cord-264884-ydkigome	1052	5	in	in	IN
cord-264884-ydkigome	1052	6	hepatitis	hepatitis	NN
cord-264884-ydkigome	1052	7	C	C	NNP
cord-264884-ydkigome	1052	8	virus	virus	NN
cord-264884-ydkigome	1052	9	infection	infection	NN
cord-264884-ydkigome	1053	1	A	a	DT
cord-264884-ydkigome	1053	2	century	century	NN
cord-264884-ydkigome	1053	3	of	of	IN
cord-264884-ydkigome	1053	4	tobamo	tobamo	NNP
cord-264884-ydkigome	1053	5	virus	virus	NN
cord-264884-ydkigome	1053	6	evolution	evolution	NN
cord-264884-ydkigome	1053	7	in	in	IN
cord-264884-ydkigome	1053	8	an	an	DT
cord-264884-ydkigome	1053	9	Australian	australian	JJ
cord-264884-ydkigome	1053	10	population	population	NN
cord-264884-ydkigome	1053	11	of	of	IN
cord-264884-ydkigome	1053	12	Nicotiana	Nicotiana	NNP
cord-264884-ydkigome	1053	13	glauca	glauca	NNP
cord-264884-ydkigome	1054	1	An	an	DT
cord-264884-ydkigome	1054	2	ancient	ancient	JJ
cord-264884-ydkigome	1054	3	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1054	4	origin	origin	NN
cord-264884-ydkigome	1054	5	of	of	IN
cord-264884-ydkigome	1054	6	the	the	DT
cord-264884-ydkigome	1054	7	Rag1/2	Rag1/2	NNP
cord-264884-ydkigome	1054	8	gene	gene	NN
cord-264884-ydkigome	1054	9	locus	locus	NN
cord-264884-ydkigome	1054	10	Prevalence	prevalence	NN
cord-264884-ydkigome	1054	11	of	of	IN
cord-264884-ydkigome	1054	12	indigenous	indigenous	JJ
cord-264884-ydkigome	1054	13	viruses	virus	NNS
cord-264884-ydkigome	1054	14	in	in	IN
cord-264884-ydkigome	1054	15	laboratory	laboratory	NN
cord-264884-ydkigome	1054	16	animal	animal	NN
cord-264884-ydkigome	1054	17	colonies	colony	NNS
cord-264884-ydkigome	1054	18	in	in	IN
cord-264884-ydkigome	1054	19	the	the	DT
cord-264884-ydkigome	1054	20	United	United	NNP
cord-264884-ydkigome	1054	21	Kingdom	Kingdom	NNP
cord-264884-ydkigome	1054	22	1978	1978	CD
cord-264884-ydkigome	1054	23	-	-	SYM
cord-264884-ydkigome	1054	24	1979	1979	CD
cord-264884-ydkigome	1054	25	Whole	Whole	NNP
cord-264884-ydkigome	1054	26	genome	genome	NN
cord-264884-ydkigome	1054	27	molecular	molecular	JJ
cord-264884-ydkigome	1054	28	phylogeny	phylogeny	NN
cord-264884-ydkigome	1054	29	of	of	IN
cord-264884-ydkigome	1054	30	large	large	JJ
cord-264884-ydkigome	1054	31	dsDNA	dsdna	JJ
cord-264884-ydkigome	1054	32	viruses	virus	NNS
cord-264884-ydkigome	1054	33	using	use	VBG
cord-264884-ydkigome	1054	34	composition	composition	NN
cord-264884-ydkigome	1054	35	vector	vector	NN
cord-264884-ydkigome	1054	36	method	method	NN
cord-264884-ydkigome	1054	37	Evolutionary	evolutionary	JJ
cord-264884-ydkigome	1054	38	transition	transition	NN
cord-264884-ydkigome	1054	39	toward	toward	IN
cord-264884-ydkigome	1054	40	defective	defective	JJ
cord-264884-ydkigome	1054	41	RNAs	rna	NNS
cord-264884-ydkigome	1054	42	that	that	WDT
cord-264884-ydkigome	1054	43	are	be	VBP
cord-264884-ydkigome	1054	44	infectious	infectious	JJ
cord-264884-ydkigome	1054	45	by	by	IN
cord-264884-ydkigome	1054	46	complementation	complementation	NN
cord-264884-ydkigome	1054	47	Retroelements	retroelement	NNS
cord-264884-ydkigome	1054	48	and	and	CC
cord-264884-ydkigome	1054	49	segmental	segmental	JJ
cord-264884-ydkigome	1054	50	duplications	duplication	NNS
cord-264884-ydkigome	1054	51	in	in	IN
cord-264884-ydkigome	1054	52	the	the	DT
cord-264884-ydkigome	1054	53	generation	generation	NN
cord-264884-ydkigome	1054	54	of	of	IN
cord-264884-ydkigome	1054	55	diversity	diversity	NN
cord-264884-ydkigome	1054	56	within	within	IN
cord-264884-ydkigome	1054	57	the	the	DT
cord-264884-ydkigome	1054	58	MHC	MHC	NNP
cord-264884-ydkigome	1055	1	The	the	DT
cord-264884-ydkigome	1055	2	Doc	Doc	NNP
cord-264884-ydkigome	1055	3	toxin	toxin	NN
cord-264884-ydkigome	1055	4	and	and	CC
cord-264884-ydkigome	1055	5	Phd	Phd	NNP
cord-264884-ydkigome	1055	6	antidote	antidote	NN
cord-264884-ydkigome	1055	7	proteins	protein	NNS
cord-264884-ydkigome	1055	8	of	of	IN
cord-264884-ydkigome	1055	9	the	the	DT
cord-264884-ydkigome	1055	10	bacteriophage	bacteriophage	NN
cord-264884-ydkigome	1055	11	P1	P1	NNP
cord-264884-ydkigome	1055	12	plasmid	plasmid	NN
cord-264884-ydkigome	1055	13	addiction	addiction	NN
cord-264884-ydkigome	1055	14	system	system	NN
cord-264884-ydkigome	1055	15	form	form	VBP
cord-264884-ydkigome	1055	16	a	a	DT
cord-264884-ydkigome	1055	17	heterotrimeric	heterotrimeric	JJ
cord-264884-ydkigome	1055	18	complex	complex	NN
cord-264884-ydkigome	1055	19	Avoidance	avoidance	NN
cord-264884-ydkigome	1055	20	of	of	IN
cord-264884-ydkigome	1055	21	palindromic	palindromic	JJ
cord-264884-ydkigome	1055	22	words	word	NNS
cord-264884-ydkigome	1055	23	in	in	IN
cord-264884-ydkigome	1055	24	bacterial	bacterial	JJ
cord-264884-ydkigome	1055	25	and	and	CC
cord-264884-ydkigome	1055	26	archaeal	archaeal	JJ
cord-264884-ydkigome	1055	27	genomes	genome	NNS
cord-264884-ydkigome	1055	28	:	:	:
cord-264884-ydkigome	1055	29	a	a	DT
cord-264884-ydkigome	1055	30	close	close	JJ
cord-264884-ydkigome	1055	31	connection	connection	NN
cord-264884-ydkigome	1055	32	with	with	IN
cord-264884-ydkigome	1055	33	restriction	restriction	NN
cord-264884-ydkigome	1055	34	enzymes	enzyme	NNS
cord-264884-ydkigome	1055	35	Mimivirus	Mimivirus	NNP
cord-264884-ydkigome	1055	36	relatives	relative	NNS
cord-264884-ydkigome	1055	37	in	in	IN
cord-264884-ydkigome	1055	38	the	the	DT
cord-264884-ydkigome	1055	39	Sargasso	Sargasso	NNP
cord-264884-ydkigome	1055	40	sea	sea	NN
cord-264884-ydkigome	1055	41	Evolution	evolution	NN
cord-264884-ydkigome	1055	42	and	and	CC
cord-264884-ydkigome	1055	43	origins	origin	NNS
cord-264884-ydkigome	1055	44	of	of	IN
cord-264884-ydkigome	1055	45	tobamoviruses	tobamoviruses	NNP
cord-264884-ydkigome	1055	46	Free	Free	NNP
cord-264884-ydkigome	1055	47	-	-	HYPH
cord-264884-ydkigome	1055	48	grazing	graze	VBG
cord-264884-ydkigome	1055	49	ducks	duck	NNS
cord-264884-ydkigome	1055	50	and	and	CC
cord-264884-ydkigome	1055	51	highly	highly	RB
cord-264884-ydkigome	1055	52	pathogenic	pathogenic	JJ
cord-264884-ydkigome	1055	53	avian	avian	JJ
cord-264884-ydkigome	1055	54	infl	infl	NN
cord-264884-ydkigome	1055	55	uenza	uenza	NNP
cord-264884-ydkigome	1055	56	Nidovirales	Nidovirales	NNP
cord-264884-ydkigome	1055	57	:	:	:
cord-264884-ydkigome	1055	58	evolving	evolve	VBG
cord-264884-ydkigome	1055	59	the	the	DT
cord-264884-ydkigome	1055	60	largest	large	JJS
cord-264884-ydkigome	1055	61	RNA	RNA	NNP
cord-264884-ydkigome	1055	62	virus	virus	NN
cord-264884-ydkigome	1055	63	genome	genome	NN
cord-264884-ydkigome	1055	64	Natural	natural	JJ
cord-264884-ydkigome	1055	65	biology	biology	NN
cord-264884-ydkigome	1055	66	of	of	IN
cord-264884-ydkigome	1055	67	polyomavirus	polyomavirus	NNP
cord-264884-ydkigome	1055	68	middle	middle	NNP
cord-264884-ydkigome	1055	69	T	T	NNP
cord-264884-ydkigome	1055	70	antigen	antigen	NN
cord-264884-ydkigome	1055	71	.	.	.
cord-264884-ydkigome	1056	1	Microbiol	Microbiol	NNP
cord-264884-ydkigome	1056	2	Suppression	Suppression	NNP
cord-264884-ydkigome	1056	3	of	of	IN
cord-264884-ydkigome	1056	4	viral	viral	JJ
cord-264884-ydkigome	1056	5	infectivity	infectivity	NN
cord-264884-ydkigome	1056	6	through	through	IN
cord-264884-ydkigome	1056	7	lethal	lethal	JJ
cord-264884-ydkigome	1056	8	defection	defection	NN
cord-264884-ydkigome	1056	9	Poxvirus	Poxvirus	NNP
cord-264884-ydkigome	1056	10	genomes	genome	NNS
cord-264884-ydkigome	1056	11	:	:	:
cord-264884-ydkigome	1056	12	a	a	DT
cord-264884-ydkigome	1056	13	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	1056	14	analysis	analysis	NN
cord-264884-ydkigome	1057	1	Maternal	maternal	JJ
cord-264884-ydkigome	1057	2	antibodies	antibody	NNS
cord-264884-ydkigome	1057	3	protect	protect	VBP
cord-264884-ydkigome	1057	4	immunoglobulin	immunoglobulin	NN
cord-264884-ydkigome	1057	5	defi	defi	FW
cord-264884-ydkigome	1057	6	cient	cient	NN
cord-264884-ydkigome	1057	7	neonatal	neonatal	JJ
cord-264884-ydkigome	1057	8	mice	mouse	NNS
cord-264884-ydkigome	1057	9	from	from	IN
cord-264884-ydkigome	1057	10	mouse	mouse	NNP
cord-264884-ydkigome	1057	11	hepatitis	hepatitis	NNP
cord-264884-ydkigome	1057	12	virus	virus	NN
cord-264884-ydkigome	1057	13	(	(	-LRB-
cord-264884-ydkigome	1057	14	MHV)-associated	mhv)-associate	VBN
cord-264884-ydkigome	1057	15	wasting	waste	VBG
cord-264884-ydkigome	1057	16	syndrome	syndrome	NN
cord-264884-ydkigome	1058	1	The	the	DT
cord-264884-ydkigome	1058	2	viriosphere	viriosphere	NN
cord-264884-ydkigome	1058	3	,	,	,
cord-264884-ydkigome	1058	4	diversity	diversity	NN
cord-264884-ydkigome	1058	5	and	and	CC
cord-264884-ydkigome	1058	6	genetic	genetic	JJ
cord-264884-ydkigome	1058	7	exchange	exchange	NN
cord-264884-ydkigome	1058	8	within	within	IN
cord-264884-ydkigome	1058	9	phage	phage	NN
cord-264884-ydkigome	1058	10	communities	community	NNS
cord-264884-ydkigome	1058	11	Impact	Impact	NNP
cord-264884-ydkigome	1058	12	of	of	IN
cord-264884-ydkigome	1058	13	phages	phage	NNS
cord-264884-ydkigome	1058	14	on	on	IN
cord-264884-ydkigome	1058	15	two	two	CD
cord-264884-ydkigome	1058	16	-	-	HYPH
cord-264884-ydkigome	1058	17	species	species	NN
cord-264884-ydkigome	1058	18	bacterial	bacterial	JJ
cord-264884-ydkigome	1058	19	communities	community	NNS
cord-264884-ydkigome	1058	20	Synthesis	Synthesis	NNP
cord-264884-ydkigome	1058	21	and	and	CC
cord-264884-ydkigome	1058	22	antiviral	antiviral	JJ
cord-264884-ydkigome	1058	23	evaluation	evaluation	NN
cord-264884-ydkigome	1058	24	of	of	IN
cord-264884-ydkigome	1058	25	a	a	DT
cord-264884-ydkigome	1058	26	mutagenic	mutagenic	JJ
cord-264884-ydkigome	1058	27	and	and	CC
cord-264884-ydkigome	1058	28	non	non	JJ
cord-264884-ydkigome	1058	29	-	-	JJ
cord-264884-ydkigome	1058	30	hydrogen	hydrogen	JJ
cord-264884-ydkigome	1058	31	bonding	bonding	NN
cord-264884-ydkigome	1058	32	ribonucleoside	ribonucleoside	NN
cord-264884-ydkigome	1058	33	analogue	analogue	NN
cord-264884-ydkigome	1058	34	:	:	:
cord-264884-ydkigome	1058	35	1-beta	1-beta	CD
cord-264884-ydkigome	1058	36	-	-	HYPH
cord-264884-ydkigome	1058	37	D	d	NN
cord-264884-ydkigome	1058	38	-	-	HYPH
cord-264884-ydkigome	1058	39	Ribofuranosyl-3-nitropyrrole	Ribofuranosyl-3-nitropyrrole	NNP
cord-264884-ydkigome	1058	40	Placental	placental	JJ
cord-264884-ydkigome	1058	41	endogenous	endogenous	JJ
cord-264884-ydkigome	1058	42	retrovirus	retrovirus	NN
cord-264884-ydkigome	1058	43	(	(	-LRB-
cord-264884-ydkigome	1058	44	ERV	ERV	NNP
cord-264884-ydkigome	1058	45	)	)	-RRB-
cord-264884-ydkigome	1058	46	:	:	:
cord-264884-ydkigome	1058	47	structural	structural	JJ
cord-264884-ydkigome	1058	48	,	,	,
cord-264884-ydkigome	1058	49	functional	functional	JJ
cord-264884-ydkigome	1058	50	and	and	CC
cord-264884-ydkigome	1058	51	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1058	52	signifi	signifi	NNP
cord-264884-ydkigome	1058	53	cance	cance	NNP
cord-264884-ydkigome	1058	54	Hantavirus	Hantavirus	NNP
cord-264884-ydkigome	1058	55	infections	infection	NNS
cord-264884-ydkigome	1058	56	:	:	:
cord-264884-ydkigome	1058	57	epidemiology	epidemiology	NN
cord-264884-ydkigome	1058	58	and	and	CC
cord-264884-ydkigome	1058	59	pathogenesis	pathogenesis	NN
cord-264884-ydkigome	1058	60	Comparative	comparative	JJ
cord-264884-ydkigome	1058	61	analysis	analysis	NN
cord-264884-ydkigome	1058	62	of	of	IN
cord-264884-ydkigome	1058	63	selected	select	VBN
cord-264884-ydkigome	1058	64	genes	gene	NNS
cord-264884-ydkigome	1058	65	from	from	IN
cord-264884-ydkigome	1058	66	Diachasmimorpha	Diachasmimorpha	NNP
cord-264884-ydkigome	1058	67	longicaudata	longicaudata	NNP
cord-264884-ydkigome	1058	68	entomopoxvirus	entomopoxvirus	NNP
cord-264884-ydkigome	1058	69	and	and	CC
cord-264884-ydkigome	1058	70	other	other	JJ
cord-264884-ydkigome	1058	71	poxviruses	poxvirus	NNS
cord-264884-ydkigome	1059	1	A	a	DT
cord-264884-ydkigome	1059	2	longitudinal	longitudinal	JJ
cord-264884-ydkigome	1059	3	study	study	NN
cord-264884-ydkigome	1059	4	of	of	IN
cord-264884-ydkigome	1059	5	an	an	DT
cord-264884-ydkigome	1059	6	endemic	endemic	JJ
cord-264884-ydkigome	1059	7	disease	disease	NN
cord-264884-ydkigome	1059	8	in	in	IN
cord-264884-ydkigome	1059	9	its	-PRON-	PRP$
cord-264884-ydkigome	1059	10	wildlife	wildlife	NN
cord-264884-ydkigome	1059	11	reservoir	reservoir	NN
cord-264884-ydkigome	1059	12	:	:	:
cord-264884-ydkigome	1059	13	cowpox	cowpox	NN
cord-264884-ydkigome	1059	14	and	and	CC
cord-264884-ydkigome	1059	15	wild	wild	JJ
cord-264884-ydkigome	1059	16	rodents	rodent	NNS
cord-264884-ydkigome	1060	1	Evolution	evolution	NN
cord-264884-ydkigome	1060	2	:	:	:
cord-264884-ydkigome	1060	3	the	the	DT
cord-264884-ydkigome	1060	4	long	long	JJ
cord-264884-ydkigome	1060	5	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1060	6	reach	reach	NN
cord-264884-ydkigome	1060	7	of	of	IN
cord-264884-ydkigome	1060	8	viruses	virus	NNS
cord-264884-ydkigome	1060	9	Bacteriophages	bacteriophage	NNS
cord-264884-ydkigome	1060	10	:	:	:
cord-264884-ydkigome	1060	11	evolution	evolution	NN
cord-264884-ydkigome	1060	12	of	of	IN
cord-264884-ydkigome	1060	13	the	the	DT
cord-264884-ydkigome	1060	14	majority	majority	NN
cord-264884-ydkigome	1060	15	.	.	.
cord-264884-ydkigome	1061	1	Theor	Theor	NNP
cord-264884-ydkigome	1061	2	Bacteriophage	Bacteriophage	NNP
cord-264884-ydkigome	1061	3	genomics	genomic	NNS
cord-264884-ydkigome	1061	4	Bacteriophages	bacteriophage	NNS
cord-264884-ydkigome	1061	5	with	with	IN
cord-264884-ydkigome	1061	6	tails	tail	NNS
cord-264884-ydkigome	1061	7	:	:	:
cord-264884-ydkigome	1062	1	chasing	chase	VBG
cord-264884-ydkigome	1062	2	their	-PRON-	PRP$
cord-264884-ydkigome	1062	3	origins	origin	NNS
cord-264884-ydkigome	1062	4	and	and	CC
cord-264884-ydkigome	1062	5	evolution	evolution	NN
cord-264884-ydkigome	1062	6	Evolutionary	evolutionary	JJ
cord-264884-ydkigome	1062	7	relationships	relationship	NNS
cord-264884-ydkigome	1062	8	among	among	IN
cord-264884-ydkigome	1062	9	diverse	diverse	JJ
cord-264884-ydkigome	1062	10	bacteriophages	bacteriophage	NNS
cord-264884-ydkigome	1062	11	and	and	CC
cord-264884-ydkigome	1062	12	prophages	prophage	VBZ
cord-264884-ydkigome	1062	13	:	:	:
cord-264884-ydkigome	1062	14	all	all	PDT
cord-264884-ydkigome	1062	15	the	the	DT
cord-264884-ydkigome	1062	16	world	world	NN
cord-264884-ydkigome	1062	17	'	'	''
cord-264884-ydkigome	1062	18	s	s	NN
cord-264884-ydkigome	1063	1	a	a	DT
cord-264884-ydkigome	1063	2	phage	phage	NN
cord-264884-ydkigome	1063	3	Use	use	NN
cord-264884-ydkigome	1063	4	of	of	IN
cord-264884-ydkigome	1063	5	whole	whole	JJ
cord-264884-ydkigome	1063	6	genome	genome	NN
cord-264884-ydkigome	1063	7	sequence	sequence	NN
cord-264884-ydkigome	1063	8	data	datum	NNS
cord-264884-ydkigome	1063	9	to	to	TO
cord-264884-ydkigome	1063	10	infer	infer	VB
cord-264884-ydkigome	1063	11	baculovirus	baculovirus	NNP
cord-264884-ydkigome	1063	12	phylogeny	phylogeny	NN
cord-264884-ydkigome	1063	13	Bacteriophage	Bacteriophage	NNP
cord-264884-ydkigome	1063	14	T4	T4	NNP
cord-264884-ydkigome	1063	15	RNA	RNA	NNP
cord-264884-ydkigome	1063	16	ligase	ligase	NN
cord-264884-ydkigome	1063	17	2	2	CD
cord-264884-ydkigome	1063	18	(	(	-LRB-
cord-264884-ydkigome	1063	19	gp24.1	gp24.1	ADD
cord-264884-ydkigome	1063	20	)	)	-RRB-
cord-264884-ydkigome	1064	1	exemplifi	exemplifi	NNP
cord-264884-ydkigome	1064	2	es	es	NNP
cord-264884-ydkigome	1064	3	a	a	DT
cord-264884-ydkigome	1064	4	family	family	NN
cord-264884-ydkigome	1064	5	of	of	IN
cord-264884-ydkigome	1064	6	RNA	RNA	NNP
cord-264884-ydkigome	1064	7	ligases	ligase	NNS
cord-264884-ydkigome	1064	8	found	find	VBN
cord-264884-ydkigome	1064	9	in	in	IN
cord-264884-ydkigome	1064	10	all	all	DT
cord-264884-ydkigome	1064	11	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	1064	12	domains	domain	NNS
cord-264884-ydkigome	1064	13	Sequence	sequence	NN
cord-264884-ydkigome	1064	14	variability	variability	NN
cord-264884-ydkigome	1064	15	in	in	IN
cord-264884-ydkigome	1064	16	the	the	DT
cord-264884-ydkigome	1064	17	env	env	NN
cord-264884-ydkigome	1064	18	-	-	HYPH
cord-264884-ydkigome	1064	19	coding	code	VBG
cord-264884-ydkigome	1064	20	region	region	NN
cord-264884-ydkigome	1064	21	of	of	IN
cord-264884-ydkigome	1064	22	hepatitis	hepatitis	NNP
cord-264884-ydkigome	1064	23	C	C	NNP
cord-264884-ydkigome	1064	24	virus	virus	NN
cord-264884-ydkigome	1064	25	isolated	isolate	VBN
cord-264884-ydkigome	1064	26	from	from	IN
cord-264884-ydkigome	1064	27	patients	patient	NNS
cord-264884-ydkigome	1064	28	infected	infect	VBN
cord-264884-ydkigome	1064	29	during	during	IN
cord-264884-ydkigome	1064	30	a	a	DT
cord-264884-ydkigome	1064	31	single	single	JJ
cord-264884-ydkigome	1064	32	source	source	NN
cord-264884-ydkigome	1064	33	outbreak	outbreak	NN
cord-264884-ydkigome	1064	34	The	the	DT
cord-264884-ydkigome	1064	35	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1064	36	biology	biology	NN
cord-264884-ydkigome	1064	37	of	of	IN
cord-264884-ydkigome	1064	38	dengue	dengue	NN
cord-264884-ydkigome	1064	39	virus	virus	NN
cord-264884-ydkigome	1065	1	The	the	DT
cord-264884-ydkigome	1065	2	origin	origin	NN
cord-264884-ydkigome	1065	3	,	,	,
cord-264884-ydkigome	1065	4	emergence	emergence	NN
cord-264884-ydkigome	1065	5	and	and	CC
cord-264884-ydkigome	1065	6	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1065	7	genetics	genetic	NNS
cord-264884-ydkigome	1065	8	of	of	IN
cord-264884-ydkigome	1065	9	dengue	dengue	NN
cord-264884-ydkigome	1065	10	virus	virus	NN
cord-264884-ydkigome	1065	11	Enterotropic	Enterotropic	NNP
cord-264884-ydkigome	1065	12	mouse	mouse	NN
cord-264884-ydkigome	1065	13	hepatitis	hepatitis	NN
cord-264884-ydkigome	1065	14	virus	virus	NN
cord-264884-ydkigome	1065	15	Albert	Albert	NNP
cord-264884-ydkigome	1065	16	B.	B.	NNP
cord-264884-ydkigome	1065	17	Sabin	Sabin	NNP
cord-264884-ydkigome	1065	18	and	and	CC
cord-264884-ydkigome	1065	19	the	the	DT
cord-264884-ydkigome	1065	20	development	development	NN
cord-264884-ydkigome	1065	21	of	of	IN
cord-264884-ydkigome	1065	22	oral	oral	JJ
cord-264884-ydkigome	1065	23	poliovaccine	poliovaccine	NNP
cord-264884-ydkigome	1065	24	Origin	Origin	NNP
cord-264884-ydkigome	1065	25	and	and	CC
cord-264884-ydkigome	1065	26	evolution	evolution	NN
cord-264884-ydkigome	1065	27	of	of	IN
cord-264884-ydkigome	1065	28	viral	viral	JJ
cord-264884-ydkigome	1065	29	interleukin-10	interleukin-10	NN
cord-264884-ydkigome	1065	30	and	and	CC
cord-264884-ydkigome	1065	31	other	other	JJ
cord-264884-ydkigome	1065	32	DNA	dna	NN
cord-264884-ydkigome	1065	33	virus	virus	NN
cord-264884-ydkigome	1065	34	genes	gene	NNS
cord-264884-ydkigome	1065	35	with	with	IN
cord-264884-ydkigome	1065	36	vertebrate	vertebrate	JJ
cord-264884-ydkigome	1065	37	homologues	homologue	NNS
cord-264884-ydkigome	1065	38	Poxvirus	Poxvirus	NNP
cord-264884-ydkigome	1065	39	genome	genome	NN
cord-264884-ydkigome	1065	40	evolution	evolution	NN
cord-264884-ydkigome	1065	41	by	by	IN
cord-264884-ydkigome	1065	42	gene	gene	NN
cord-264884-ydkigome	1065	43	gain	gain	NN
cord-264884-ydkigome	1065	44	and	and	CC
cord-264884-ydkigome	1065	45	loss	loss	NN
cord-264884-ydkigome	1065	46	Accessory	accessory	NN
cord-264884-ydkigome	1065	47	DNA	dna	NN
cord-264884-ydkigome	1065	48	in	in	IN
cord-264884-ydkigome	1065	49	the	the	DT
cord-264884-ydkigome	1065	50	genomes	genome	NNS
cord-264884-ydkigome	1065	51	of	of	IN
cord-264884-ydkigome	1065	52	representatives	representative	NNS
cord-264884-ydkigome	1065	53	of	of	IN
cord-264884-ydkigome	1065	54	the	the	DT
cord-264884-ydkigome	1065	55	Escherichia	Escherichia	NNP
cord-264884-ydkigome	1065	56	coli	coli	NNS
cord-264884-ydkigome	1065	57	reference	reference	NN
cord-264884-ydkigome	1065	58	collection	collection	NN
cord-264884-ydkigome	1065	59	Isolation	isolation	NN
cord-264884-ydkigome	1065	60	of	of	IN
cord-264884-ydkigome	1065	61	mouse	mouse	NN
cord-264884-ydkigome	1065	62	hepatitis	hepatitis	NN
cord-264884-ydkigome	1065	63	virus	virus	NN
cord-264884-ydkigome	1065	64	from	from	IN
cord-264884-ydkigome	1065	65	infant	infant	NN
cord-264884-ydkigome	1065	66	mice	mouse	NNS
cord-264884-ydkigome	1065	67	with	with	IN
cord-264884-ydkigome	1065	68	fatal	fatal	JJ
cord-264884-ydkigome	1065	69	diarrhea	diarrhea	NN
cord-264884-ydkigome	1066	1	Common	common	JJ
cord-264884-ydkigome	1066	2	origin	origin	NN
cord-264884-ydkigome	1066	3	of	of	IN
cord-264884-ydkigome	1066	4	four	four	CD
cord-264884-ydkigome	1066	5	diverse	diverse	JJ
cord-264884-ydkigome	1066	6	families	family	NNS
cord-264884-ydkigome	1066	7	of	of	IN
cord-264884-ydkigome	1066	8	large	large	JJ
cord-264884-ydkigome	1066	9	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	1066	10	DNA	dna	NN
cord-264884-ydkigome	1066	11	viruses	virus	NNS
cord-264884-ydkigome	1066	12	Evolutionary	evolutionary	JJ
cord-264884-ydkigome	1066	13	genomics	genomic	NNS
cord-264884-ydkigome	1066	14	of	of	IN
cord-264884-ydkigome	1066	15	nucleo	nucleo	JJ
cord-264884-ydkigome	1066	16	-	-	JJ
cord-264884-ydkigome	1066	17	cytoplasmic	cytoplasmic	JJ
cord-264884-ydkigome	1066	18	large	large	JJ
cord-264884-ydkigome	1066	19	DNA	dna	NN
cord-264884-ydkigome	1066	20	viruses	virus	NNS
cord-264884-ydkigome	1066	21	Avipoxvirus	Avipoxvirus	NNP
cord-264884-ydkigome	1066	22	phylogenetics	phylogenetic	NNS
cord-264884-ydkigome	1066	23	:	:	:
cord-264884-ydkigome	1066	24	identifi	identifi	NNP
cord-264884-ydkigome	1066	25	cation	cation	NNP
cord-264884-ydkigome	1066	26	of	of	IN
cord-264884-ydkigome	1066	27	a	a	DT
cord-264884-ydkigome	1066	28	PCR	PCR	NNP
cord-264884-ydkigome	1066	29	length	length	NN
cord-264884-ydkigome	1066	30	polymorphism	polymorphism	NN
cord-264884-ydkigome	1066	31	that	that	WDT
cord-264884-ydkigome	1066	32	discriminates	discriminate	VBZ
cord-264884-ydkigome	1066	33	between	between	IN
cord-264884-ydkigome	1066	34	the	the	DT
cord-264884-ydkigome	1066	35	two	two	CD
cord-264884-ydkigome	1066	36	major	major	JJ
cord-264884-ydkigome	1066	37	clades	clade	NNS
cord-264884-ydkigome	1066	38	Use	use	VBP
cord-264884-ydkigome	1066	39	of	of	IN
cord-264884-ydkigome	1066	40	endogenous	endogenous	JJ
cord-264884-ydkigome	1066	41	retroviral	retroviral	NN
cord-264884-ydkigome	1066	42	sequences	sequence	NNS
cord-264884-ydkigome	1066	43	(	(	-LRB-
cord-264884-ydkigome	1066	44	ERVs	ERVs	NNP
cord-264884-ydkigome	1066	45	)	)	-RRB-
cord-264884-ydkigome	1066	46	and	and	CC
cord-264884-ydkigome	1066	47	structural	structural	JJ
cord-264884-ydkigome	1066	48	markers	marker	NNS
cord-264884-ydkigome	1066	49	for	for	IN
cord-264884-ydkigome	1066	50	retroviral	retroviral	JJ
cord-264884-ydkigome	1066	51	phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	1066	52	inference	inference	NN
cord-264884-ydkigome	1066	53	and	and	CC
cord-264884-ydkigome	1066	54	taxonomy	taxonomy	NN
cord-264884-ydkigome	1066	55	RAG1	RAG1	NNP
cord-264884-ydkigome	1066	56	core	core	NN
cord-264884-ydkigome	1066	57	and	and	CC
cord-264884-ydkigome	1066	58	V(D)J	V(D)J	NNP
cord-264884-ydkigome	1066	59	recombination	recombination	NN
cord-264884-ydkigome	1066	60	signal	signal	NN
cord-264884-ydkigome	1066	61	sequences	sequence	NNS
cord-264884-ydkigome	1066	62	were	be	VBD
cord-264884-ydkigome	1066	63	derived	derive	VBN
cord-264884-ydkigome	1066	64	from	from	IN
cord-264884-ydkigome	1066	65	Transib	Transib	NNP
cord-264884-ydkigome	1066	66	transposons	transposon	NNS
cord-264884-ydkigome	1066	67	Small	small	JJ
cord-264884-ydkigome	1066	68	mammal	mammal	NN
cord-264884-ydkigome	1066	69	virology	virology	NN
cord-264884-ydkigome	1066	70	Structure	structure	NN
cord-264884-ydkigome	1066	71	of	of	IN
cord-264884-ydkigome	1066	72	an	an	DT
cord-264884-ydkigome	1066	73	archaeal	archaeal	JJ
cord-264884-ydkigome	1066	74	virus	virus	NN
cord-264884-ydkigome	1066	75	capsid	capsid	NN
cord-264884-ydkigome	1066	76	protein	protein	NN
cord-264884-ydkigome	1066	77	reveals	reveal	VBZ
cord-264884-ydkigome	1066	78	a	a	DT
cord-264884-ydkigome	1066	79	common	common	JJ
cord-264884-ydkigome	1066	80	ancestry	ancestry	NN
cord-264884-ydkigome	1066	81	to	to	IN
cord-264884-ydkigome	1066	82	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	1066	83	and	and	CC
cord-264884-ydkigome	1066	84	bacterial	bacterial	JJ
cord-264884-ydkigome	1066	85	viruses	virus	NNS
cord-264884-ydkigome	1066	86	HIV	HIV	NNP
cord-264884-ydkigome	1066	87	diversity	diversity	NN
cord-264884-ydkigome	1066	88	,	,	,
cord-264884-ydkigome	1066	89	molecular	molecular	JJ
cord-264884-ydkigome	1066	90	epidemiology	epidemiology	NN
cord-264884-ydkigome	1066	91	and	and	CC
cord-264884-ydkigome	1066	92	the	the	DT
cord-264884-ydkigome	1066	93	role	role	NN
cord-264884-ydkigome	1066	94	of	of	IN
cord-264884-ydkigome	1066	95	recombination	recombination	NN
cord-264884-ydkigome	1066	96	Origin	Origin	NNP
cord-264884-ydkigome	1066	97	of	of	IN
cord-264884-ydkigome	1066	98	human	human	JJ
cord-264884-ydkigome	1066	99	immunodefi	immunodefi	NNP
cord-264884-ydkigome	1066	100	ciency	ciency	NNP
cord-264884-ydkigome	1066	101	virus	virus	NNP
cord-264884-ydkigome	1066	102	type	type	NN
cord-264884-ydkigome	1066	103	1	1	CD
cord-264884-ydkigome	1066	104	quasispecies	quasispecie	NNS
cord-264884-ydkigome	1066	105	emerging	emerge	VBG
cord-264884-ydkigome	1066	106	after	after	IN
cord-264884-ydkigome	1066	107	antiretroviral	antiretroviral	JJ
cord-264884-ydkigome	1066	108	treatment	treatment	NN
cord-264884-ydkigome	1066	109	interruption	interruption	NN
cord-264884-ydkigome	1066	110	in	in	IN
cord-264884-ydkigome	1066	111	patients	patient	NNS
cord-264884-ydkigome	1066	112	with	with	IN
cord-264884-ydkigome	1066	113	therapeutic	therapeutic	JJ
cord-264884-ydkigome	1066	114	failure	failure	NN
cord-264884-ydkigome	1066	115	Virus	Virus	NNP
cord-264884-ydkigome	1066	116	persistence	persistence	NN
cord-264884-ydkigome	1066	117	and	and	CC
cord-264884-ydkigome	1066	118	recurring	recur	VBG
cord-264884-ydkigome	1066	119	demyelination	demyelination	NN
cord-264884-ydkigome	1066	120	produced	produce	VBN
cord-264884-ydkigome	1066	121	by	by	IN
cord-264884-ydkigome	1066	122	a	a	DT
cord-264884-ydkigome	1066	123	temperature	temperature	NN
cord-264884-ydkigome	1066	124	-	-	HYPH
cord-264884-ydkigome	1066	125	sensitive	sensitive	JJ
cord-264884-ydkigome	1066	126	mutant	mutant	NN
cord-264884-ydkigome	1066	127	of	of	IN
cord-264884-ydkigome	1066	128	MHV-4	MHV-4	NNP
cord-264884-ydkigome	1066	129	Horizontal	horizontal	JJ
cord-264884-ydkigome	1066	130	gene	gene	NN
cord-264884-ydkigome	1066	131	transfer	transfer	NN
cord-264884-ydkigome	1066	132	in	in	IN
cord-264884-ydkigome	1066	133	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	1066	134	:	:	:
cord-264884-ydkigome	1066	135	quantifi	quantifi	NNP
cord-264884-ydkigome	1066	136	cation	cation	NNP
cord-264884-ydkigome	1066	137	and	and	CC
cord-264884-ydkigome	1066	138	classifi	classifi	NNP
cord-264884-ydkigome	1066	139	cation	cation	NN
cord-264884-ydkigome	1066	140	Structurefunction	Structurefunction	NNP
cord-264884-ydkigome	1066	141	relationships	relationship	NNS
cord-264884-ydkigome	1066	142	of	of	IN
cord-264884-ydkigome	1066	143	the	the	DT
cord-264884-ydkigome	1066	144	viral	viral	JJ
cord-264884-ydkigome	1066	145	RNA	RNA	NNP
cord-264884-ydkigome	1066	146	-	-	HYPH
cord-264884-ydkigome	1066	147	dependent	dependent	JJ
cord-264884-ydkigome	1066	148	RNA	RNA	NNP
cord-264884-ydkigome	1066	149	polymerase	polymerase	NN
cord-264884-ydkigome	1066	150	:	:	:
cord-264884-ydkigome	1066	151	Fidelity	fidelity	NN
cord-264884-ydkigome	1066	152	,	,	,
cord-264884-ydkigome	1066	153	replication	replication	NN
cord-264884-ydkigome	1066	154	speed	speed	NN
cord-264884-ydkigome	1066	155	and	and	CC
cord-264884-ydkigome	1066	156	initiation	initiation	NN
cord-264884-ydkigome	1066	157	mechanism	mechanism	NN
cord-264884-ydkigome	1066	158	determined	determine	VBN
cord-264884-ydkigome	1066	159	by	by	IN
cord-264884-ydkigome	1066	160	a	a	DT
cord-264884-ydkigome	1066	161	residue	residue	NN
cord-264884-ydkigome	1066	162	in	in	IN
cord-264884-ydkigome	1066	163	the	the	DT
cord-264884-ydkigome	1066	164	ribose	ribose	NN
cord-264884-ydkigome	1066	165	-	-	HYPH
cord-264884-ydkigome	1066	166	binding	bind	VBG
cord-264884-ydkigome	1066	167	pocket	pocket	NN
cord-264884-ydkigome	1067	1	The	the	DT
cord-264884-ydkigome	1067	2	evolution	evolution	NN
cord-264884-ydkigome	1067	3	of	of	IN
cord-264884-ydkigome	1067	4	MHC	MHC	NNP
cord-264884-ydkigome	1067	5	diversity	diversity	NN
cord-264884-ydkigome	1067	6	by	by	IN
cord-264884-ydkigome	1067	7	segmental	segmental	JJ
cord-264884-ydkigome	1067	8	duplication	duplication	NN
cord-264884-ydkigome	1067	9	and	and	CC
cord-264884-ydkigome	1067	10	transposition	transposition	NN
cord-264884-ydkigome	1067	11	of	of	IN
cord-264884-ydkigome	1067	12	retroelements	retroelement	NNS
cord-264884-ydkigome	1067	13	Comparison	comparison	NN
cord-264884-ydkigome	1067	14	between	between	IN
cord-264884-ydkigome	1067	15	two	two	CD
cord-264884-ydkigome	1067	16	human	human	JJ
cord-264884-ydkigome	1067	17	endogenous	endogenous	JJ
cord-264884-ydkigome	1067	18	retrovirus	retrovirus	NN
cord-264884-ydkigome	1067	19	(	(	-LRB-
cord-264884-ydkigome	1067	20	HERV)-rich	herv)-rich	CD
cord-264884-ydkigome	1067	21	regions	region	NNS
cord-264884-ydkigome	1067	22	within	within	IN
cord-264884-ydkigome	1067	23	the	the	DT
cord-264884-ydkigome	1067	24	major	major	JJ
cord-264884-ydkigome	1067	25	histocompatibility	histocompatibility	NN
cord-264884-ydkigome	1067	26	complex	complex	NN
cord-264884-ydkigome	1067	27	ERVK9	ERVK9	NNP
cord-264884-ydkigome	1067	28	,	,	,
cord-264884-ydkigome	1067	29	transposons	transposon	NNS
cord-264884-ydkigome	1067	30	and	and	CC
cord-264884-ydkigome	1067	31	the	the	DT
cord-264884-ydkigome	1067	32	evolution	evolution	NN
cord-264884-ydkigome	1067	33	of	of	IN
cord-264884-ydkigome	1067	34	MHC	MHC	NNP
cord-264884-ydkigome	1067	35	class	class	NN
cord-264884-ydkigome	1067	36	I	-PRON-	PRP
cord-264884-ydkigome	1067	37	duplicons	duplicon	VBZ
cord-264884-ydkigome	1067	38	within	within	IN
cord-264884-ydkigome	1067	39	the	the	DT
cord-264884-ydkigome	1067	40	alpha	alpha	NN
cord-264884-ydkigome	1067	41	-	-	HYPH
cord-264884-ydkigome	1067	42	block	block	NN
cord-264884-ydkigome	1067	43	of	of	IN
cord-264884-ydkigome	1067	44	the	the	DT
cord-264884-ydkigome	1067	45	human	human	JJ
cord-264884-ydkigome	1067	46	and	and	CC
cord-264884-ydkigome	1067	47	chimpanzee	chimpanzee	NN
cord-264884-ydkigome	1067	48	Interactions	interaction	NNS
cord-264884-ydkigome	1067	49	between	between	IN
cord-264884-ydkigome	1067	50	Retroviruses	retrovirus	NNS
cord-264884-ydkigome	1067	51	and	and	CC
cord-264884-ydkigome	1067	52	Herpesviruses	Herpesviruses	NNP
cord-264884-ydkigome	1067	53	.	.	.
cord-264884-ydkigome	1068	1	Singapore	Singapore	NNP
cord-264884-ydkigome	1068	2	;	;	:
cord-264884-ydkigome	1068	3	River	River	NNP
cord-264884-ydkigome	1068	4	Edge	Edge	NNP
cord-264884-ydkigome	1068	5	Evolution	Evolution	NNP
cord-264884-ydkigome	1068	6	and	and	CC
cord-264884-ydkigome	1068	7	selection	selection	NN
cord-264884-ydkigome	1068	8	of	of	IN
cord-264884-ydkigome	1068	9	hepatitis	hepatitis	NN
cord-264884-ydkigome	1068	10	C	C	NNP
cord-264884-ydkigome	1068	11	virus	virus	NN
cord-264884-ydkigome	1068	12	variants	variant	NNS
cord-264884-ydkigome	1068	13	in	in	IN
cord-264884-ydkigome	1068	14	patients	patient	NNS
cord-264884-ydkigome	1068	15	with	with	IN
cord-264884-ydkigome	1068	16	chronic	chronic	JJ
cord-264884-ydkigome	1068	17	hepatitis	hepatitis	NN
cord-264884-ydkigome	1068	18	C	C	NNP
cord-264884-ydkigome	1068	19	KSHV	KSHV	NNP
cord-264884-ydkigome	1068	20	-	-	HYPH
cord-264884-ydkigome	1068	21	like	like	JJ
cord-264884-ydkigome	1068	22	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	1068	23	in	in	IN
cord-264884-ydkigome	1068	24	chimps	chimp	NNS
cord-264884-ydkigome	1068	25	and	and	CC
cord-264884-ydkigome	1068	26	gorillas	gorilla	NNS
cord-264884-ydkigome	1068	27	Plasmid	Plasmid	NNP
cord-264884-ydkigome	1068	28	addiction	addiction	NN
cord-264884-ydkigome	1068	29	genes	gene	NNS
cord-264884-ydkigome	1068	30	of	of	IN
cord-264884-ydkigome	1068	31	bacteriophage	bacteriophage	NN
cord-264884-ydkigome	1068	32	P1	p1	NN
cord-264884-ydkigome	1068	33	:	:	:
cord-264884-ydkigome	1068	34	doc	doc	NN
cord-264884-ydkigome	1068	35	,	,	,
cord-264884-ydkigome	1068	36	which	which	WDT
cord-264884-ydkigome	1068	37	causes	cause	VBZ
cord-264884-ydkigome	1068	38	cell	cell	NN
cord-264884-ydkigome	1068	39	death	death	NN
cord-264884-ydkigome	1068	40	on	on	IN
cord-264884-ydkigome	1068	41	curing	curing	NN
cord-264884-ydkigome	1068	42	of	of	IN
cord-264884-ydkigome	1068	43	prophage	prophage	NN
cord-264884-ydkigome	1068	44	and	and	CC
cord-264884-ydkigome	1068	45	phd	phd	NNP
cord-264884-ydkigome	1068	46	,	,	,
cord-264884-ydkigome	1068	47	which	which	WDT
cord-264884-ydkigome	1068	48	prevents	prevent	VBZ
cord-264884-ydkigome	1068	49	host	host	NN
cord-264884-ydkigome	1068	50	death	death	NN
cord-264884-ydkigome	1068	51	when	when	WRB
cord-264884-ydkigome	1068	52	prophage	prophage	NN
cord-264884-ydkigome	1068	53	is	be	VBZ
cord-264884-ydkigome	1068	54	retained	retain	VBN
cord-264884-ydkigome	1068	55	Evolution	evolution	NN
cord-264884-ydkigome	1068	56	and	and	CC
cord-264884-ydkigome	1068	57	persistence	persistence	NN
cord-264884-ydkigome	1068	58	of	of	IN
cord-264884-ydkigome	1069	1	infl	infl	NNP
cord-264884-ydkigome	1069	2	uenza	uenza	NNP
cord-264884-ydkigome	1069	3	A	A	NNP
cord-264884-ydkigome	1069	4	and	and	CC
cord-264884-ydkigome	1069	5	other	other	JJ
cord-264884-ydkigome	1069	6	diseases	disease	NNS
cord-264884-ydkigome	1069	7	Bats	bat	NNS
cord-264884-ydkigome	1069	8	are	be	VBP
cord-264884-ydkigome	1069	9	natural	natural	JJ
cord-264884-ydkigome	1069	10	reservoirs	reservoir	NNS
cord-264884-ydkigome	1069	11	of	of	IN
cord-264884-ydkigome	1069	12	SARS	SARS	NNP
cord-264884-ydkigome	1069	13	-	-	HYPH
cord-264884-ydkigome	1069	14	like	like	JJ
cord-264884-ydkigome	1069	15	coronaviruses	coronaviruse	NNS
cord-264884-ydkigome	1069	16	Transfer	Transfer	NNP
cord-264884-ydkigome	1069	17	of	of	IN
cord-264884-ydkigome	1069	18	photosynthesis	photosynthesis	NN
cord-264884-ydkigome	1069	19	genes	gene	NNS
cord-264884-ydkigome	1069	20	to	to	IN
cord-264884-ydkigome	1069	21	and	and	CC
cord-264884-ydkigome	1069	22	from	from	IN
cord-264884-ydkigome	1069	23	Prochlorococcus	Prochlorococcus	NNP
cord-264884-ydkigome	1069	24	viruses	virus	NNS
cord-264884-ydkigome	1070	1	Protein	protein	NN
cord-264884-ydkigome	1070	2	repertoire	repertoire	NN
cord-264884-ydkigome	1070	3	of	of	IN
cord-264884-ydkigome	1070	4	double	double	RB
cord-264884-ydkigome	1070	5	-	-	HYPH
cord-264884-ydkigome	1070	6	stranded	strand	VBN
cord-264884-ydkigome	1070	7	DNA	dna	NN
cord-264884-ydkigome	1070	8	bacteriophages	bacteriophage	NNS
cord-264884-ydkigome	1070	9	Characterization	characterization	NN
cord-264884-ydkigome	1070	10	of	of	IN
cord-264884-ydkigome	1070	11	the	the	DT
cord-264884-ydkigome	1070	12	primary	primary	JJ
cord-264884-ydkigome	1070	13	immunity	immunity	NN
cord-264884-ydkigome	1070	14	region	region	NN
cord-264884-ydkigome	1070	15	of	of	IN
cord-264884-ydkigome	1070	16	the	the	DT
cord-264884-ydkigome	1070	17	Escherichia	Escherichia	NNP
cord-264884-ydkigome	1070	18	coli	coli	NNS
cord-264884-ydkigome	1070	19	linear	linear	JJ
cord-264884-ydkigome	1070	20	plasmid	plasmid	NN
cord-264884-ydkigome	1070	21	prophage	prophage	NN
cord-264884-ydkigome	1070	22	N15	N15	NNP
cord-264884-ydkigome	1070	23	Parvovirus	Parvovirus	NNP
cord-264884-ydkigome	1070	24	variation	variation	NN
cord-264884-ydkigome	1070	25	for	for	IN
cord-264884-ydkigome	1070	26	disease	disease	NN
cord-264884-ydkigome	1070	27	:	:	:
cord-264884-ydkigome	1070	28	a	a	DT
cord-264884-ydkigome	1070	29	difference	difference	NN
cord-264884-ydkigome	1070	30	with	with	IN
cord-264884-ydkigome	1070	31	RNA	RNA	NNP
cord-264884-ydkigome	1070	32	viruses	virus	NNS
cord-264884-ydkigome	1070	33	?	?	.
cord-264884-ydkigome	1071	1	Cross	cross	NN
cord-264884-ydkigome	1071	2	-	-	NNS
cord-264884-ydkigome	1071	3	species	species	JJ
cord-264884-ydkigome	1071	4	transfer	transfer	NN
cord-264884-ydkigome	1071	5	of	of	IN
cord-264884-ydkigome	1071	6	viruses	virus	NNS
cord-264884-ydkigome	1071	7	:	:	:
cord-264884-ydkigome	1071	8	implications	implication	NNS
cord-264884-ydkigome	1071	9	for	for	IN
cord-264884-ydkigome	1071	10	the	the	DT
cord-264884-ydkigome	1071	11	use	use	NN
cord-264884-ydkigome	1071	12	of	of	IN
cord-264884-ydkigome	1071	13	viral	viral	JJ
cord-264884-ydkigome	1071	14	vectors	vector	NNS
cord-264884-ydkigome	1071	15	in	in	IN
cord-264884-ydkigome	1071	16	biomedical	biomedical	JJ
cord-264884-ydkigome	1071	17	research	research	NN
cord-264884-ydkigome	1071	18	,	,	,
cord-264884-ydkigome	1071	19	gene	gene	NN
cord-264884-ydkigome	1071	20	therapy	therapy	NN
cord-264884-ydkigome	1071	21	and	and	CC
cord-264884-ydkigome	1071	22	as	as	IN
cord-264884-ydkigome	1071	23	live	live	NN
cord-264884-ydkigome	1071	24	-	-	HYPH
cord-264884-ydkigome	1071	25	virus	virus	NN
cord-264884-ydkigome	1071	26	vaccines	vaccine	NNS
cord-264884-ydkigome	1071	27	Bacteriophage	Bacteriophage	NNP
cord-264884-ydkigome	1071	28	:	:	:
cord-264884-ydkigome	1071	29	an	an	DT
cord-264884-ydkigome	1071	30	essay	essay	NN
cord-264884-ydkigome	1071	31	on	on	IN
cord-264884-ydkigome	1071	32	virus	virus	NN
cord-264884-ydkigome	1071	33	reproduction	reproduction	NN
cord-264884-ydkigome	1071	34	Mutations	mutation	NNS
cord-264884-ydkigome	1071	35	of	of	IN
cord-264884-ydkigome	1071	36	bacteria	bacteria	NNS
cord-264884-ydkigome	1071	37	from	from	IN
cord-264884-ydkigome	1071	38	virus	virus	NN
cord-264884-ydkigome	1071	39	sensitivity	sensitivity	NN
cord-264884-ydkigome	1071	40	to	to	IN
cord-264884-ydkigome	1071	41	virus	virus	NN
cord-264884-ydkigome	1071	42	resistance	resistance	NN
cord-264884-ydkigome	1071	43	Virus	virus	NN
cord-264884-ydkigome	1071	44	growth	growth	NN
cord-264884-ydkigome	1071	45	and	and	CC
cord-264884-ydkigome	1071	46	variation	variation	NN
cord-264884-ydkigome	1071	47	:	:	:
cord-264884-ydkigome	1071	48	Ninth	ninth	JJ
cord-264884-ydkigome	1071	49	symposium	symposium	NN
cord-264884-ydkigome	1071	50	of	of	IN
cord-264884-ydkigome	1071	51	the	the	DT
cord-264884-ydkigome	1071	52	society	society	NN
cord-264884-ydkigome	1071	53	for	for	IN
cord-264884-ydkigome	1071	54	general	general	JJ
cord-264884-ydkigome	1071	55	microbiology	microbiology	NN
cord-264884-ydkigome	1071	56	Prevalence	prevalence	NN
cord-264884-ydkigome	1071	57	of	of	IN
cord-264884-ydkigome	1071	58	natural	natural	JJ
cord-264884-ydkigome	1071	59	virus	virus	NN
cord-264884-ydkigome	1071	60	infections	infection	NNS
cord-264884-ydkigome	1071	61	in	in	IN
cord-264884-ydkigome	1071	62	laboratory	laboratory	NN
cord-264884-ydkigome	1071	63	mice	mouse	NNS
cord-264884-ydkigome	1071	64	and	and	CC
cord-264884-ydkigome	1071	65	rats	rat	NNS
cord-264884-ydkigome	1071	66	used	use	VBN
cord-264884-ydkigome	1071	67	in	in	IN
cord-264884-ydkigome	1071	68	Canada	Canada	NNP
cord-264884-ydkigome	1071	69	Different	different	JJ
cord-264884-ydkigome	1071	70	patterns	pattern	NNS
cord-264884-ydkigome	1071	71	of	of	IN
cord-264884-ydkigome	1071	72	molecular	molecular	JJ
cord-264884-ydkigome	1071	73	evolution	evolution	NN
cord-264884-ydkigome	1071	74	of	of	IN
cord-264884-ydkigome	1071	75	infl	infl	NN
cord-264884-ydkigome	1071	76	uenza	uenza	NNP
cord-264884-ydkigome	1071	77	A	a	DT
cord-264884-ydkigome	1071	78	viruses	virus	NNS
cord-264884-ydkigome	1071	79	in	in	IN
cord-264884-ydkigome	1071	80	avian	avian	JJ
cord-264884-ydkigome	1071	81	and	and	CC
cord-264884-ydkigome	1071	82	human	human	JJ
cord-264884-ydkigome	1071	83	populations	population	NNS
cord-264884-ydkigome	1071	84	Crystal	Crystal	NNP
cord-264884-ydkigome	1071	85	structure	structure	NN
cord-264884-ydkigome	1071	86	of	of	IN
cord-264884-ydkigome	1071	87	poliovirus	poliovirus	NN
cord-264884-ydkigome	1071	88	3CD	3cd	CD
cord-264884-ydkigome	1071	89	protein	protein	NN
cord-264884-ydkigome	1071	90	:	:	:
cord-264884-ydkigome	1071	91	virally	virally	RB
cord-264884-ydkigome	1071	92	encoded	encode	VBN
cord-264884-ydkigome	1071	93	protease	protease	NN
cord-264884-ydkigome	1071	94	and	and	CC
cord-264884-ydkigome	1071	95	precursor	precursor	NN
cord-264884-ydkigome	1071	96	to	to	IN
cord-264884-ydkigome	1071	97	the	the	DT
cord-264884-ydkigome	1071	98	RNA	RNA	NNP
cord-264884-ydkigome	1071	99	-	-	HYPH
cord-264884-ydkigome	1071	100	dependent	dependent	JJ
cord-264884-ydkigome	1071	101	RNA	RNA	NNP
cord-264884-ydkigome	1071	102	polymerase	polymerase	NN
cord-264884-ydkigome	1071	103	Symbiosis	symbiosis	NN
cord-264884-ydkigome	1071	104	as	as	IN
cord-264884-ydkigome	1071	105	a	a	DT
cord-264884-ydkigome	1071	106	mechanism	mechanism	NN
cord-264884-ydkigome	1071	107	of	of	IN
cord-264884-ydkigome	1071	108	evolution	evolution	NN
cord-264884-ydkigome	1071	109	:	:	:
cord-264884-ydkigome	1071	110	status	status	NN
cord-264884-ydkigome	1071	111	of	of	IN
cord-264884-ydkigome	1071	112	cell	cell	NN
cord-264884-ydkigome	1071	113	symbiosis	symbiosis	NN
cord-264884-ydkigome	1071	114	theory	theory	NN
cord-264884-ydkigome	1072	1	A	a	DT
cord-264884-ydkigome	1072	2	virus	virus	NN
cord-264884-ydkigome	1072	3	in	in	IN
cord-264884-ydkigome	1072	4	a	a	DT
cord-264884-ydkigome	1072	5	fungus	fungus	NN
cord-264884-ydkigome	1072	6	in	in	IN
cord-264884-ydkigome	1072	7	a	a	DT
cord-264884-ydkigome	1072	8	plant	plant	NN
cord-264884-ydkigome	1072	9	:	:	:
cord-264884-ydkigome	1072	10	three	three	CD
cord-264884-ydkigome	1072	11	-	-	HYPH
cord-264884-ydkigome	1072	12	way	way	NN
cord-264884-ydkigome	1072	13	symbiosis	symbiosis	NN
cord-264884-ydkigome	1072	14	required	require	VBN
cord-264884-ydkigome	1072	15	for	for	IN
cord-264884-ydkigome	1072	16	thermal	thermal	JJ
cord-264884-ydkigome	1072	17	tolerance	tolerance	NN
cord-264884-ydkigome	1072	18	Hepatitis	Hepatitis	NNP
cord-264884-ydkigome	1072	19	C	C	NNP
cord-264884-ydkigome	1072	20	virus	virus	NN
cord-264884-ydkigome	1072	21	(	(	-LRB-
cord-264884-ydkigome	1072	22	HCV	HCV	NNP
cord-264884-ydkigome	1072	23	)	)	-RRB-
cord-264884-ydkigome	1072	24	circulates	circulate	VBZ
cord-264884-ydkigome	1072	25	as	as	IN
cord-264884-ydkigome	1072	26	a	a	DT
cord-264884-ydkigome	1072	27	population	population	NN
cord-264884-ydkigome	1072	28	of	of	IN
cord-264884-ydkigome	1072	29	different	different	JJ
cord-264884-ydkigome	1072	30	but	but	CC
cord-264884-ydkigome	1072	31	closely	closely	RB
cord-264884-ydkigome	1072	32	related	related	JJ
cord-264884-ydkigome	1072	33	genomes	genome	NNS
cord-264884-ydkigome	1072	34	:	:	:
cord-264884-ydkigome	1072	35	quasispecies	quasispecie	NNS
cord-264884-ydkigome	1072	36	nature	nature	NN
cord-264884-ydkigome	1072	37	of	of	IN
cord-264884-ydkigome	1072	38	HCV	HCV	NNP
cord-264884-ydkigome	1072	39	genome	genome	NN
cord-264884-ydkigome	1072	40	distribution	distribution	NN
cord-264884-ydkigome	1072	41	MHV	MHV	NNP
cord-264884-ydkigome	1072	42	infection	infection	NN
cord-264884-ydkigome	1072	43	of	of	IN
cord-264884-ydkigome	1072	44	the	the	DT
cord-264884-ydkigome	1072	45	CNS	CNS	NNP
cord-264884-ydkigome	1072	46	:	:	:
cord-264884-ydkigome	1072	47	mechanisms	mechanism	NNS
cord-264884-ydkigome	1072	48	of	of	IN
cord-264884-ydkigome	1072	49	immunemediated	immunemediated	JJ
cord-264884-ydkigome	1072	50	control	control	NN
cord-264884-ydkigome	1072	51	Molecular	molecular	JJ
cord-264884-ydkigome	1072	52	dynamics	dynamic	NNS
cord-264884-ydkigome	1072	53	of	of	IN
cord-264884-ydkigome	1072	54	Emiliania	Emiliania	NNP
cord-264884-ydkigome	1072	55	huxleyi	huxleyi	NNP
cord-264884-ydkigome	1072	56	and	and	CC
cord-264884-ydkigome	1072	57	cooccurring	cooccurre	VBG
cord-264884-ydkigome	1072	58	viruses	virus	NNS
cord-264884-ydkigome	1072	59	during	during	IN
cord-264884-ydkigome	1072	60	two	two	CD
cord-264884-ydkigome	1072	61	separate	separate	JJ
cord-264884-ydkigome	1072	62	mesocosm	mesocosm	NN
cord-264884-ydkigome	1072	63	studies	study	NNS
cord-264884-ydkigome	1072	64	Role	role	NN
cord-264884-ydkigome	1072	65	of	of	IN
cord-264884-ydkigome	1072	66	disease	disease	NN
cord-264884-ydkigome	1072	67	in	in	IN
cord-264884-ydkigome	1072	68	abundance	abundance	NN
cord-264884-ydkigome	1072	69	of	of	IN
cord-264884-ydkigome	1072	70	a	a	DT
cord-264884-ydkigome	1072	71	Pacifi	Pacifi	NNP
cord-264884-ydkigome	1072	72	c	c	NN
cord-264884-ydkigome	1072	73	herring	herring	NN
cord-264884-ydkigome	1072	74	(	(	-LRB-
cord-264884-ydkigome	1072	75	Clupea	Clupea	NNP
cord-264884-ydkigome	1072	76	pallasi	pallasi	NNP
cord-264884-ydkigome	1072	77	)	)	-RRB-
cord-264884-ydkigome	1072	78	population	population	NN
cord-264884-ydkigome	1072	79	.	.	.
cord-264884-ydkigome	1073	1	Can	Can	MD
cord-264884-ydkigome	1073	2	Antibiotic	antibiotic	JJ
cord-264884-ydkigome	1073	3	resistance	resistance	NN
cord-264884-ydkigome	1073	4	in	in	IN
cord-264884-ydkigome	1073	5	the	the	DT
cord-264884-ydkigome	1073	6	ECOR	ECOR	NNP
cord-264884-ydkigome	1073	7	collection	collection	NN
cord-264884-ydkigome	1073	8	:	:	:
cord-264884-ydkigome	1073	9	integrons	integrons	NNP
cord-264884-ydkigome	1073	10	and	and	CC
cord-264884-ydkigome	1073	11	identifi	identifi	NNP
cord-264884-ydkigome	1073	12	cation	cation	NNP
cord-264884-ydkigome	1073	13	of	of	IN
cord-264884-ydkigome	1073	14	a	a	DT
cord-264884-ydkigome	1073	15	novel	novel	JJ
cord-264884-ydkigome	1073	16	aad	aad	NNP
cord-264884-ydkigome	1073	17	gene	gene	NN
cord-264884-ydkigome	1073	18	Evolution	Evolution	NNP
cord-264884-ydkigome	1073	19	of	of	IN
cord-264884-ydkigome	1073	20	the	the	DT
cord-264884-ydkigome	1073	21	dUTPase	dUTPase	NNP
cord-264884-ydkigome	1073	22	gene	gene	NN
cord-264884-ydkigome	1073	23	of	of	IN
cord-264884-ydkigome	1073	24	mammalian	mammalian	JJ
cord-264884-ydkigome	1073	25	and	and	CC
cord-264884-ydkigome	1073	26	avian	avian	JJ
cord-264884-ydkigome	1073	27	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	1074	1	The	the	DT
cord-264884-ydkigome	1074	2	descent	descent	NN
cord-264884-ydkigome	1074	3	of	of	IN
cord-264884-ydkigome	1074	4	human	human	JJ
cord-264884-ydkigome	1074	5	herpesvirus	herpesvirus	NNP
cord-264884-ydkigome	1074	6	8	8	CD
cord-264884-ydkigome	1074	7	Integrating	integrate	VBG
cord-264884-ydkigome	1074	8	reptilian	reptilian	JJ
cord-264884-ydkigome	1074	9	herpesviruses	herpesviruse	NNS
cord-264884-ydkigome	1074	10	into	into	IN
cord-264884-ydkigome	1074	11	the	the	DT
cord-264884-ydkigome	1074	12	family	family	NN
cord-264884-ydkigome	1074	13	herpesviridae	herpesviridae	NN
cord-264884-ydkigome	1074	14	Toward	toward	IN
cord-264884-ydkigome	1074	15	a	a	DT
cord-264884-ydkigome	1074	16	comprehensive	comprehensive	JJ
cord-264884-ydkigome	1074	17	phylogeny	phylogeny	NN
cord-264884-ydkigome	1074	18	for	for	IN
cord-264884-ydkigome	1074	19	mammalian	mammalian	JJ
cord-264884-ydkigome	1074	20	and	and	CC
cord-264884-ydkigome	1074	21	avian	avian	JJ
cord-264884-ydkigome	1074	22	herpesviruses	herpesviruses	FW
cord-264884-ydkigome	1074	23	Topics	topic	NNS
cord-264884-ydkigome	1074	24	in	in	IN
cord-264884-ydkigome	1074	25	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	1074	26	genomics	genomic	NNS
cord-264884-ydkigome	1074	27	and	and	CC
cord-264884-ydkigome	1074	28	evolution	evolution	NN
cord-264884-ydkigome	1074	29	HIV	HIV	NNP
cord-264884-ydkigome	1074	30	and	and	CC
cord-264884-ydkigome	1074	31	human	human	JJ
cord-264884-ydkigome	1074	32	endogenous	endogenous	JJ
cord-264884-ydkigome	1074	33	retroviruses	retrovirus	NNS
cord-264884-ydkigome	1074	34	:	:	:
cord-264884-ydkigome	1074	35	an	an	DT
cord-264884-ydkigome	1074	36	hypothesis	hypothesis	NN
cord-264884-ydkigome	1074	37	with	with	IN
cord-264884-ydkigome	1074	38	therapeutic	therapeutic	JJ
cord-264884-ydkigome	1074	39	implications	implication	NNS
cord-264884-ydkigome	1075	1	The	the	DT
cord-264884-ydkigome	1075	2	genome	genome	NN
cord-264884-ydkigome	1075	3	of	of	IN
cord-264884-ydkigome	1075	4	bacteriophage	bacteriophage	NN
cord-264884-ydkigome	1075	5	phiKZ	phiKZ	NNP
cord-264884-ydkigome	1075	6	of	of	IN
cord-264884-ydkigome	1075	7	Pseudomonas	Pseudomonas	NNP
cord-264884-ydkigome	1075	8	aeruginosa	aeruginosa	NNP
cord-264884-ydkigome	1075	9	Syncytin	Syncytin	NNP
cord-264884-ydkigome	1075	10	is	be	VBZ
cord-264884-ydkigome	1075	11	a	a	DT
cord-264884-ydkigome	1075	12	captive	captive	JJ
cord-264884-ydkigome	1075	13	retroviral	retroviral	NN
cord-264884-ydkigome	1075	14	envelope	envelope	NN
cord-264884-ydkigome	1075	15	protein	protein	NN
cord-264884-ydkigome	1075	16	involved	involve	VBN
cord-264884-ydkigome	1075	17	in	in	IN
cord-264884-ydkigome	1075	18	human	human	JJ
cord-264884-ydkigome	1075	19	placental	placental	NN
cord-264884-ydkigome	1075	20	morphogenesis	morphogenesis	NN
cord-264884-ydkigome	1075	21	Algorithms	Algorithms	NNP
cord-264884-ydkigome	1075	22	for	for	IN
cord-264884-ydkigome	1075	23	computing	compute	VBG
cord-264884-ydkigome	1075	24	parsimonious	parsimonious	JJ
cord-264884-ydkigome	1075	25	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1075	26	scenarios	scenario	NNS
cord-264884-ydkigome	1075	27	for	for	IN
cord-264884-ydkigome	1075	28	genome	genome	NN
cord-264884-ydkigome	1075	29	evolution	evolution	NN
cord-264884-ydkigome	1075	30	,	,	,
cord-264884-ydkigome	1075	31	the	the	DT
cord-264884-ydkigome	1075	32	last	last	JJ
cord-264884-ydkigome	1075	33	universal	universal	JJ
cord-264884-ydkigome	1075	34	common	common	JJ
cord-264884-ydkigome	1075	35	ancestor	ancestor	NN
cord-264884-ydkigome	1075	36	and	and	CC
cord-264884-ydkigome	1075	37	dominance	dominance	NN
cord-264884-ydkigome	1075	38	of	of	IN
cord-264884-ydkigome	1075	39	horizontal	horizontal	JJ
cord-264884-ydkigome	1075	40	gene	gene	NN
cord-264884-ydkigome	1075	41	transfer	transfer	NN
cord-264884-ydkigome	1075	42	in	in	IN
cord-264884-ydkigome	1075	43	the	the	DT
cord-264884-ydkigome	1075	44	evolution	evolution	NN
cord-264884-ydkigome	1075	45	of	of	IN
cord-264884-ydkigome	1075	46	prokaryotes	prokaryote	NNS
cord-264884-ydkigome	1075	47	Apoptotic	Apoptotic	NNP
cord-264884-ydkigome	1075	48	-	-	HYPH
cord-264884-ydkigome	1075	49	like	like	JJ
cord-264884-ydkigome	1075	50	morphology	morphology	NN
cord-264884-ydkigome	1075	51	is	be	VBZ
cord-264884-ydkigome	1075	52	associated	associate	VBN
cord-264884-ydkigome	1075	53	with	with	IN
cord-264884-ydkigome	1075	54	annual	annual	JJ
cord-264884-ydkigome	1075	55	synchronized	synchronized	JJ
cord-264884-ydkigome	1075	56	death	death	NN
cord-264884-ydkigome	1075	57	in	in	IN
cord-264884-ydkigome	1075	58	kleptoplastic	kleptoplastic	JJ
cord-264884-ydkigome	1075	59	sea	sea	NN
cord-264884-ydkigome	1075	60	slugs	slug	NNS
cord-264884-ydkigome	1076	1	(	(	-LRB-
cord-264884-ydkigome	1076	2	Elysia	Elysia	NNP
cord-264884-ydkigome	1076	3	chlorotica	chlorotica	NNP
cord-264884-ydkigome	1076	4	)	)	-RRB-
cord-264884-ydkigome	1077	1	The	the	DT
cord-264884-ydkigome	1077	2	players	player	NNS
cord-264884-ydkigome	1077	3	in	in	IN
cord-264884-ydkigome	1077	4	a	a	DT
cord-264884-ydkigome	1077	5	mutualistic	mutualistic	JJ
cord-264884-ydkigome	1077	6	symbiosis	symbiosis	NN
cord-264884-ydkigome	1077	7	:	:	:
cord-264884-ydkigome	1077	8	insects	insect	NNS
cord-264884-ydkigome	1077	9	,	,	,
cord-264884-ydkigome	1077	10	bacteria	bacteria	NNS
cord-264884-ydkigome	1077	11	,	,	,
cord-264884-ydkigome	1077	12	viruses	virus	NNS
cord-264884-ydkigome	1077	13	and	and	CC
cord-264884-ydkigome	1077	14	virulence	virulence	NN
cord-264884-ydkigome	1077	15	genes	gene	NNS
cord-264884-ydkigome	1077	16	Low	low	JJ
cord-264884-ydkigome	1077	17	genetic	genetic	JJ
cord-264884-ydkigome	1077	18	barrier	barrier	NN
cord-264884-ydkigome	1077	19	to	to	IN
cord-264884-ydkigome	1077	20	large	large	JJ
cord-264884-ydkigome	1077	21	increases	increase	NNS
cord-264884-ydkigome	1077	22	in	in	IN
cord-264884-ydkigome	1077	23	HIV-1	HIV-1	NNP
cord-264884-ydkigome	1077	24	cross	cross	NN
cord-264884-ydkigome	1077	25	-	-	NN
cord-264884-ydkigome	1077	26	resistance	resistance	NN
cord-264884-ydkigome	1077	27	to	to	IN
cord-264884-ydkigome	1077	28	protease	protease	NN
cord-264884-ydkigome	1077	29	inhibitors	inhibitor	NNS
cord-264884-ydkigome	1077	30	during	during	IN
cord-264884-ydkigome	1077	31	salvage	salvage	NN
cord-264884-ydkigome	1077	32	therapy	therapy	NN
cord-264884-ydkigome	1077	33	Comment	comment	NN
cord-264884-ydkigome	1077	34	on	on	IN
cord-264884-ydkigome	1077	35	'	'	''
cord-264884-ydkigome	1077	36	The	the	DT
cord-264884-ydkigome	1077	37	1.2-megabase	1.2-megabase	CD
cord-264884-ydkigome	1077	38	genome	genome	NN
cord-264884-ydkigome	1077	39	sequence	sequence	NN
cord-264884-ydkigome	1077	40	of	of	IN
cord-264884-ydkigome	1077	41	Mimivirus	Mimivirus	NNP
cord-264884-ydkigome	1077	42	Murine	Murine	NNP
cord-264884-ydkigome	1077	43	viruses	virus	NNS
cord-264884-ydkigome	1077	44	in	in	IN
cord-264884-ydkigome	1077	45	an	an	DT
cord-264884-ydkigome	1077	46	island	island	NN
cord-264884-ydkigome	1077	47	population	population	NN
cord-264884-ydkigome	1077	48	of	of	IN
cord-264884-ydkigome	1077	49	introduced	introduce	VBN
cord-264884-ydkigome	1077	50	house	house	NN
cord-264884-ydkigome	1077	51	mice	mouse	NNS
cord-264884-ydkigome	1077	52	and	and	CC
cord-264884-ydkigome	1077	53	endemic	endemic	JJ
cord-264884-ydkigome	1077	54	short	short	JJ
cord-264884-ydkigome	1077	55	-	-	HYPH
cord-264884-ydkigome	1077	56	tailed	tailed	JJ
cord-264884-ydkigome	1077	57	mice	mouse	NNS
cord-264884-ydkigome	1077	58	in	in	IN
cord-264884-ydkigome	1077	59	Western	Western	NNP
cord-264884-ydkigome	1077	60	Australia	Australia	NNP
cord-264884-ydkigome	1077	61	Pathogens	Pathogens	NNPS
cord-264884-ydkigome	1077	62	of	of	IN
cord-264884-ydkigome	1077	63	house	house	NN
cord-264884-ydkigome	1077	64	mice	mouse	NNS
cord-264884-ydkigome	1077	65	on	on	IN
cord-264884-ydkigome	1077	66	arid	arid	JJ
cord-264884-ydkigome	1077	67	Boullanger	Boullanger	NNP
cord-264884-ydkigome	1077	68	Island	Island	NNP
cord-264884-ydkigome	1077	69	and	and	CC
cord-264884-ydkigome	1077	70	subantarctic	subantarctic	JJ
cord-264884-ydkigome	1077	71	Macquarie	Macquarie	NNP
cord-264884-ydkigome	1077	72	Island	Island	NNP
cord-264884-ydkigome	1078	1	Late	late	JJ
cord-264884-ydkigome	1078	2	viral	viral	JJ
cord-264884-ydkigome	1078	3	interference	interference	NN
cord-264884-ydkigome	1078	4	induced	induce	VBN
cord-264884-ydkigome	1078	5	by	by	IN
cord-264884-ydkigome	1078	6	transdominant	transdominant	JJ
cord-264884-ydkigome	1078	7	Gag	Gag	NNP
cord-264884-ydkigome	1078	8	of	of	IN
cord-264884-ydkigome	1078	9	an	an	DT
cord-264884-ydkigome	1078	10	endogenous	endogenous	JJ
cord-264884-ydkigome	1078	11	retrovirus	retrovirus	NN
cord-264884-ydkigome	1079	1	The	the	DT
cord-264884-ydkigome	1079	2	transdominant	transdominant	JJ
cord-264884-ydkigome	1079	3	endogenous	endogenous	JJ
cord-264884-ydkigome	1079	4	retrovirus	retrovirus	NN
cord-264884-ydkigome	1079	5	enJS56A1	enjs56a1	CD
cord-264884-ydkigome	1079	6	associates	associate	NNS
cord-264884-ydkigome	1079	7	with	with	IN
cord-264884-ydkigome	1079	8	and	and	CC
cord-264884-ydkigome	1079	9	blocks	block	VBZ
cord-264884-ydkigome	1079	10	intracellular	intracellular	JJ
cord-264884-ydkigome	1079	11	traffi	traffi	NNP
cord-264884-ydkigome	1079	12	cking	cking	NN
cord-264884-ydkigome	1079	13	of	of	IN
cord-264884-ydkigome	1079	14	Jaagsiekte	Jaagsiekte	NNP
cord-264884-ydkigome	1079	15	sheep	sheep	NN
cord-264884-ydkigome	1079	16	retrovirus	retrovirus	NN
cord-264884-ydkigome	1079	17	Gag	Gag	NNP
cord-264884-ydkigome	1079	18	Foamy	Foamy	NNP
cord-264884-ydkigome	1079	19	virus	virus	NN
cord-264884-ydkigome	1079	20	infection	infection	NN
cord-264884-ydkigome	1079	21	in	in	IN
cord-264884-ydkigome	1079	22	primates	primate	NNS
cord-264884-ydkigome	1080	1	The	the	DT
cord-264884-ydkigome	1080	2	minimal	minimal	JJ
cord-264884-ydkigome	1080	3	genome	genome	NN
cord-264884-ydkigome	1080	4	concept	concept	NN
cord-264884-ydkigome	1080	5	Algal	algal	JJ
cord-264884-ydkigome	1080	6	viruses	virus	NNS
cord-264884-ydkigome	1080	7	with	with	IN
cord-264884-ydkigome	1080	8	distinct	distinct	JJ
cord-264884-ydkigome	1080	9	intraspecies	intraspecie	NNS
cord-264884-ydkigome	1080	10	host	host	NN
cord-264884-ydkigome	1080	11	specifi	specifi	NN
cord-264884-ydkigome	1080	12	cities	city	NNS
cord-264884-ydkigome	1080	13	include	include	VBP
cord-264884-ydkigome	1080	14	identical	identical	JJ
cord-264884-ydkigome	1080	15	intein	intein	NNP
cord-264884-ydkigome	1080	16	elements	element	NNS
cord-264884-ydkigome	1080	17	Human	human	JJ
cord-264884-ydkigome	1080	18	endogenous	endogenous	JJ
cord-264884-ydkigome	1080	19	retroviruses	retrovirus	NNS
cord-264884-ydkigome	1080	20	with	with	IN
cord-264884-ydkigome	1080	21	transcriptional	transcriptional	JJ
cord-264884-ydkigome	1080	22	potential	potential	NN
cord-264884-ydkigome	1080	23	in	in	IN
cord-264884-ydkigome	1080	24	the	the	DT
cord-264884-ydkigome	1080	25	brain	brain	NN
cord-264884-ydkigome	1081	1	The	the	DT
cord-264884-ydkigome	1081	2	structure	structure	NN
cord-264884-ydkigome	1081	3	and	and	CC
cord-264884-ydkigome	1081	4	evolution	evolution	NN
cord-264884-ydkigome	1081	5	of	of	IN
cord-264884-ydkigome	1081	6	the	the	DT
cord-264884-ydkigome	1081	7	major	major	JJ
cord-264884-ydkigome	1081	8	capsid	capsid	NN
cord-264884-ydkigome	1081	9	protein	protein	NN
cord-264884-ydkigome	1081	10	of	of	IN
cord-264884-ydkigome	1081	11	a	a	DT
cord-264884-ydkigome	1081	12	large	large	JJ
cord-264884-ydkigome	1081	13	,	,	,
cord-264884-ydkigome	1081	14	lipidcontaining	lipidcontaine	VBG
cord-264884-ydkigome	1081	15	DNA	dna	NN
cord-264884-ydkigome	1081	16	virus	virus	NN
cord-264884-ydkigome	1081	17	Lack	lack	NN
cord-264884-ydkigome	1081	18	of	of	IN
cord-264884-ydkigome	1081	19	the	the	DT
cord-264884-ydkigome	1081	20	canonical	canonical	JJ
cord-264884-ydkigome	1081	21	pRB	prb	NN
cord-264884-ydkigome	1081	22	-	-	HYPH
cord-264884-ydkigome	1081	23	binding	bind	VBG
cord-264884-ydkigome	1081	24	domain	domain	NN
cord-264884-ydkigome	1081	25	in	in	IN
cord-264884-ydkigome	1081	26	the	the	DT
cord-264884-ydkigome	1081	27	E7	E7	NNP
cord-264884-ydkigome	1081	28	ORF	ORF	NNP
cord-264884-ydkigome	1081	29	of	of	IN
cord-264884-ydkigome	1081	30	artiodactyl	artiodactyl	NN
cord-264884-ydkigome	1081	31	papillomaviruses	papillomaviruse	NNS
cord-264884-ydkigome	1081	32	is	be	VBZ
cord-264884-ydkigome	1081	33	associated	associate	VBN
cord-264884-ydkigome	1081	34	with	with	IN
cord-264884-ydkigome	1081	35	the	the	DT
cord-264884-ydkigome	1081	36	development	development	NN
cord-264884-ydkigome	1081	37	of	of	IN
cord-264884-ydkigome	1081	38	fi	fi	NNP
cord-264884-ydkigome	1081	39	bropapillomas	bropapillomas	NNP
cord-264884-ydkigome	1081	40	Thermus	Thermus	NNP
cord-264884-ydkigome	1081	41	thermophilus	thermophilus	NN
cord-264884-ydkigome	1081	42	bacteriophage	bacteriophage	NN
cord-264884-ydkigome	1081	43	phiYS40	phiYS40	NNP
cord-264884-ydkigome	1081	44	genome	genome	NN
cord-264884-ydkigome	1081	45	and	and	CC
cord-264884-ydkigome	1081	46	proteomic	proteomic	JJ
cord-264884-ydkigome	1081	47	characterization	characterization	NN
cord-264884-ydkigome	1081	48	of	of	IN
cord-264884-ydkigome	1081	49	virions	virion	NNS
cord-264884-ydkigome	1081	50	Natural	natural	JJ
cord-264884-ydkigome	1081	51	history	history	NN
cord-264884-ydkigome	1081	52	of	of	IN
cord-264884-ydkigome	1081	53	murine	murine	JJ
cord-264884-ydkigome	1081	54	gamma	gamma	NN
cord-264884-ydkigome	1081	55	-	-	HYPH
cord-264884-ydkigome	1081	56	herpesvirus	herpesvirus	NN
cord-264884-ydkigome	1081	57	infection	infection	NN
cord-264884-ydkigome	1081	58	Molecular	molecular	JJ
cord-264884-ydkigome	1081	59	biodiversity	biodiversity	NN
cord-264884-ydkigome	1081	60	of	of	IN
cord-264884-ydkigome	1081	61	cassava	cassava	NN
cord-264884-ydkigome	1081	62	begomoviruses	begomoviruse	NNS
cord-264884-ydkigome	1081	63	in	in	IN
cord-264884-ydkigome	1081	64	Tanzania	Tanzania	NNP
cord-264884-ydkigome	1081	65	:	:	:
cord-264884-ydkigome	1081	66	evolution	evolution	NN
cord-264884-ydkigome	1081	67	of	of	IN
cord-264884-ydkigome	1081	68	cassava	cassava	NN
cord-264884-ydkigome	1081	69	geminiviruses	geminiviruse	NNS
cord-264884-ydkigome	1081	70	in	in	IN
cord-264884-ydkigome	1081	71	Africa	Africa	NNP
cord-264884-ydkigome	1081	72	and	and	CC
cord-264884-ydkigome	1081	73	evidence	evidence	NN
cord-264884-ydkigome	1081	74	for	for	IN
cord-264884-ydkigome	1081	75	East	East	NNP
cord-264884-ydkigome	1081	76	Africa	Africa	NNP
cord-264884-ydkigome	1081	77	being	be	VBG
cord-264884-ydkigome	1081	78	a	a	DT
cord-264884-ydkigome	1081	79	center	center	NN
cord-264884-ydkigome	1081	80	of	of	IN
cord-264884-ydkigome	1081	81	diversity	diversity	NN
cord-264884-ydkigome	1081	82	of	of	IN
cord-264884-ydkigome	1081	83	cassava	cassava	NN
cord-264884-ydkigome	1081	84	geminiviruses	geminiviruse	NNS
cord-264884-ydkigome	1082	1	The	the	DT
cord-264884-ydkigome	1082	2	evolution	evolution	NN
cord-264884-ydkigome	1082	3	of	of	IN
cord-264884-ydkigome	1082	4	epidemic	epidemic	NN
cord-264884-ydkigome	1082	5	infl	infl	XX
cord-264884-ydkigome	1082	6	uenza	uenza	NNP
cord-264884-ydkigome	1082	7	Novel	Novel	NNP
cord-264884-ydkigome	1082	8	organizational	organizational	JJ
cord-264884-ydkigome	1082	9	features	feature	NNS
cord-264884-ydkigome	1082	10	,	,	,
cord-264884-ydkigome	1082	11	captured	capture	VBD
cord-264884-ydkigome	1082	12	cellular	cellular	JJ
cord-264884-ydkigome	1082	13	genes	gene	NNS
cord-264884-ydkigome	1082	14	and	and	CC
cord-264884-ydkigome	1082	15	strain	strain	VB
cord-264884-ydkigome	1082	16	variability	variability	NN
cord-264884-ydkigome	1082	17	within	within	IN
cord-264884-ydkigome	1082	18	the	the	DT
cord-264884-ydkigome	1082	19	genome	genome	NN
cord-264884-ydkigome	1082	20	of	of	IN
cord-264884-ydkigome	1082	21	KSHV	KSHV	NNP
cord-264884-ydkigome	1082	22	/	/	SYM
cord-264884-ydkigome	1082	23	HHV8	HHV8	NNP
cord-264884-ydkigome	1082	24	Site	site	NN
cord-264884-ydkigome	1082	25	-	-	HYPH
cord-264884-ydkigome	1082	26	specifi	specifi	NN
cord-264884-ydkigome	1082	27	c	c	NN
cord-264884-ydkigome	1082	28	recombination	recombination	NN
cord-264884-ydkigome	1082	29	links	link	VBZ
cord-264884-ydkigome	1082	30	the	the	DT
cord-264884-ydkigome	1082	31	evolution	evolution	NN
cord-264884-ydkigome	1082	32	of	of	IN
cord-264884-ydkigome	1082	33	P2-like	p2-like	IN
cord-264884-ydkigome	1082	34	coliphages	coliphage	NNS
cord-264884-ydkigome	1082	35	and	and	CC
cord-264884-ydkigome	1082	36	pathogenic	pathogenic	JJ
cord-264884-ydkigome	1082	37	enterobacteria	enterobacteria	JJ
cord-264884-ydkigome	1082	38	Genetic	genetic	JJ
cord-264884-ydkigome	1082	39	diversity	diversity	NN
cord-264884-ydkigome	1082	40	among	among	IN
cord-264884-ydkigome	1082	41	fi	fi	NNP
cord-264884-ydkigome	1082	42	ve	ve	NNP
cord-264884-ydkigome	1082	43	T4-like	t4-like	IN
cord-264884-ydkigome	1082	44	bacteriophages	bacteriophage	NNS
cord-264884-ydkigome	1083	1	Exponential	exponential	JJ
cord-264884-ydkigome	1083	2	increases	increase	NNS
cord-264884-ydkigome	1083	3	of	of	IN
cord-264884-ydkigome	1083	4	RNA	RNA	NNP
cord-264884-ydkigome	1083	5	virus	virus	NN
cord-264884-ydkigome	1083	6	fi	fi	NN
cord-264884-ydkigome	1083	7	tness	tness	NN
cord-264884-ydkigome	1083	8	during	during	IN
cord-264884-ydkigome	1083	9	large	large	JJ
cord-264884-ydkigome	1083	10	population	population	NN
cord-264884-ydkigome	1083	11	transmissions	transmission	NNS
cord-264884-ydkigome	1083	12	Lack	lack	NN
cord-264884-ydkigome	1083	13	of	of	IN
cord-264884-ydkigome	1083	14	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1083	15	stasis	stasis	NN
cord-264884-ydkigome	1083	16	during	during	IN
cord-264884-ydkigome	1083	17	alternating	alternate	VBG
cord-264884-ydkigome	1083	18	replication	replication	NN
cord-264884-ydkigome	1083	19	of	of	IN
cord-264884-ydkigome	1083	20	an	an	DT
cord-264884-ydkigome	1083	21	arbovirus	arbovirus	NN
cord-264884-ydkigome	1083	22	in	in	IN
cord-264884-ydkigome	1083	23	insect	insect	NN
cord-264884-ydkigome	1083	24	and	and	CC
cord-264884-ydkigome	1083	25	mammalian	mammalian	JJ
cord-264884-ydkigome	1083	26	cells	cell	NNS
cord-264884-ydkigome	1084	1	A	a	DT
cord-264884-ydkigome	1084	2	new	new	JJ
cord-264884-ydkigome	1084	3	example	example	NN
cord-264884-ydkigome	1084	4	of	of	IN
cord-264884-ydkigome	1084	5	viral	viral	JJ
cord-264884-ydkigome	1084	6	intein	intein	NN
cord-264884-ydkigome	1084	7	in	in	IN
cord-264884-ydkigome	1084	8	Mimivirus	Mimivirus	NNP
cord-264884-ydkigome	1084	9	Adaptive	Adaptive	NNP
cord-264884-ydkigome	1084	10	evolution	evolution	NN
cord-264884-ydkigome	1084	11	and	and	CC
cord-264884-ydkigome	1084	12	antiviral	antiviral	JJ
cord-264884-ydkigome	1084	13	activity	activity	NN
cord-264884-ydkigome	1084	14	of	of	IN
cord-264884-ydkigome	1084	15	the	the	DT
cord-264884-ydkigome	1084	16	conserved	conserved	JJ
cord-264884-ydkigome	1084	17	mammalian	mammalian	JJ
cord-264884-ydkigome	1084	18	cytidine	cytidine	NN
cord-264884-ydkigome	1084	19	deaminase	deaminase	NNP
cord-264884-ydkigome	1084	20	APOBEC3H	APOBEC3H	NNP
cord-264884-ydkigome	1084	21	Genetic	genetic	JJ
cord-264884-ydkigome	1084	22	heterogeneity	heterogeneity	NN
cord-264884-ydkigome	1084	23	of	of	IN
cord-264884-ydkigome	1084	24	hepatitis	hepatitis	NN
cord-264884-ydkigome	1084	25	C	C	NNP
cord-264884-ydkigome	1084	26	virus	virus	NN
cord-264884-ydkigome	1085	1	In	in	IN
cord-264884-ydkigome	1085	2	vitro	vitro	FW
cord-264884-ydkigome	1085	3	characterization	characterization	NN
cord-264884-ydkigome	1085	4	of	of	IN
cord-264884-ydkigome	1085	5	a	a	DT
cord-264884-ydkigome	1085	6	koala	koala	NN
cord-264884-ydkigome	1085	7	retrovirus	retrovirus	NN
cord-264884-ydkigome	1085	8	Selfi	Selfi	NNP
cord-264884-ydkigome	1085	9	sh	sh	NN
cord-264884-ydkigome	1085	10	DNA	DNA	NNP
cord-264884-ydkigome	1085	11	:	:	:
cord-264884-ydkigome	1085	12	the	the	DT
cord-264884-ydkigome	1085	13	ultimate	ultimate	JJ
cord-264884-ydkigome	1085	14	parasite	parasite	NN
cord-264884-ydkigome	1085	15	Hot	hot	JJ
cord-264884-ydkigome	1085	16	crenarchaeal	crenarchaeal	NN
cord-264884-ydkigome	1085	17	viruses	virus	NNS
cord-264884-ydkigome	1085	18	reveal	reveal	VBP
cord-264884-ydkigome	1085	19	deep	deep	JJ
cord-264884-ydkigome	1085	20	evolutionary	evolutionary	JJ
cord-264884-ydkigome	1085	21	connections	connection	NNS
cord-264884-ydkigome	1085	22	Encyclopedia	Encyclopedia	NNP
cord-264884-ydkigome	1085	23	of	of	IN
cord-264884-ydkigome	1085	24	Evolution	Evolution	NNP
cord-264884-ydkigome	1085	25	Identifi	Identifi	NNP
cord-264884-ydkigome	1085	26	cation	cation	NN
cord-264884-ydkigome	1085	27	and	and	CC
cord-264884-ydkigome	1085	28	genetic	genetic	JJ
cord-264884-ydkigome	1085	29	diversity	diversity	NN
cord-264884-ydkigome	1085	30	of	of	IN
cord-264884-ydkigome	1085	31	two	two	CD
cord-264884-ydkigome	1085	32	human	human	JJ
cord-264884-ydkigome	1085	33	parvovirus	parvovirus	NN
cord-264884-ydkigome	1085	34	B19	B19	NNP
cord-264884-ydkigome	1085	35	genotype	genotype	NN
cord-264884-ydkigome	1085	36	3	3	CD
cord-264884-ydkigome	1085	37	subtypes	subtype	NNS
cord-264884-ydkigome	1086	1	Marine	marine	JJ
cord-264884-ydkigome	1086	2	phage	phage	NN
cord-264884-ydkigome	1086	3	genomics	genomic	NNS
cord-264884-ydkigome	1086	4	Cloning	cloning	NN
cord-264884-ydkigome	1086	5	,	,	,
cord-264884-ydkigome	1086	6	expression	expression	NN
cord-264884-ydkigome	1086	7	,	,	,
cord-264884-ydkigome	1086	8	purifi	purifi	NNP
cord-264884-ydkigome	1086	9	cation	cation	NN
cord-264884-ydkigome	1086	10	and	and	CC
cord-264884-ydkigome	1086	11	characterisation	characterisation	NN
cord-264884-ydkigome	1086	12	of	of	IN
cord-264884-ydkigome	1086	13	the	the	DT
cord-264884-ydkigome	1086	14	dUTPase	dUTPase	NNP
cord-264884-ydkigome	1086	15	encoded	encode	VBN
cord-264884-ydkigome	1086	16	by	by	IN
cord-264884-ydkigome	1086	17	the	the	DT
cord-264884-ydkigome	1086	18	integrated	integrated	JJ
cord-264884-ydkigome	1086	19	Bacillus	Bacillus	NNP
cord-264884-ydkigome	1086	20	subtilis	subtili	NNS
cord-264884-ydkigome	1086	21	temperate	temperate	JJ
cord-264884-ydkigome	1086	22	bacteriophage	bacteriophage	NN
cord-264884-ydkigome	1087	1	SPbeta	spbeta	JJ
cord-264884-ydkigome	1087	2	Increased	increase	VBN
cord-264884-ydkigome	1087	3	fi	fi	NN
cord-264884-ydkigome	1087	4	delity	delity	NN
cord-264884-ydkigome	1087	5	reduces	reduce	VBZ
cord-264884-ydkigome	1087	6	poliovirus	poliovirus	NN
cord-264884-ydkigome	1087	7	fi	fi	IN
cord-264884-ydkigome	1087	8	tness	tness	NN
cord-264884-ydkigome	1087	9	and	and	CC
cord-264884-ydkigome	1087	10	virulence	virulence	NN
cord-264884-ydkigome	1087	11	under	under	IN
cord-264884-ydkigome	1087	12	selective	selective	JJ
cord-264884-ydkigome	1087	13	pressure	pressure	NN
cord-264884-ydkigome	1087	14	in	in	IN
cord-264884-ydkigome	1087	15	mice	mouse	NNS
cord-264884-ydkigome	1088	1	Bottleneckmediated	Bottleneckmediated	NNP
cord-264884-ydkigome	1088	2	quasispecies	quasispecie	VBZ
cord-264884-ydkigome	1088	3	restriction	restriction	NN
cord-264884-ydkigome	1088	4	during	during	IN
cord-264884-ydkigome	1088	5	spread	spread	NN
cord-264884-ydkigome	1088	6	of	of	IN
cord-264884-ydkigome	1088	7	an	an	DT
cord-264884-ydkigome	1088	8	RNA	RNA	NNP
cord-264884-ydkigome	1088	9	virus	virus	NN
cord-264884-ydkigome	1088	10	from	from	IN
cord-264884-ydkigome	1088	11	inoculation	inoculation	NN
cord-264884-ydkigome	1088	12	site	site	NN
cord-264884-ydkigome	1088	13	to	to	TO
cord-264884-ydkigome	1088	14	brain	brain	VB
cord-264884-ydkigome	1088	15	Annual	annual	JJ
cord-264884-ydkigome	1088	16	viral	viral	JJ
cord-264884-ydkigome	1088	17	expression	expression	NN
cord-264884-ydkigome	1088	18	in	in	IN
cord-264884-ydkigome	1088	19	a	a	DT
cord-264884-ydkigome	1088	20	sea	sea	NN
cord-264884-ydkigome	1088	21	slug	slug	NN
cord-264884-ydkigome	1088	22	population	population	NN
cord-264884-ydkigome	1088	23	:	:	:
cord-264884-ydkigome	1088	24	Life	life	NN
cord-264884-ydkigome	1088	25	cycle	cycle	NN
cord-264884-ydkigome	1088	26	control	control	NN
cord-264884-ydkigome	1088	27	and	and	CC
cord-264884-ydkigome	1088	28	symbiotic	symbiotic	JJ
cord-264884-ydkigome	1088	29	chloroplast	chloroplast	NN
cord-264884-ydkigome	1088	30	maintenance	maintenance	NN
cord-264884-ydkigome	1088	31	a	a	NN
cord-264884-ydkigome	1088	32	)	)	-RRB-
cord-264884-ydkigome	1088	33	Viruses	virus	NNS
cord-264884-ydkigome	1088	34	of	of	IN
cord-264884-ydkigome	1088	35	the	the	DT
cord-264884-ydkigome	1088	36	Archaea	Archaea	NNP
cord-264884-ydkigome	1088	37	:	:	:
cord-264884-ydkigome	1088	38	a	a	DT
cord-264884-ydkigome	1088	39	unifying	unifying	JJ
cord-264884-ydkigome	1088	40	view	view	NN
cord-264884-ydkigome	1088	41	b	b	NN
cord-264884-ydkigome	1088	42	)	)	-RRB-
cord-264884-ydkigome	1089	1	Evolutionary	evolutionary	JJ
cord-264884-ydkigome	1089	2	genomics	genomic	NNS
cord-264884-ydkigome	1089	3	of	of	IN
cord-264884-ydkigome	1089	4	archaeal	archaeal	JJ
cord-264884-ydkigome	1089	5	viruses	virus	NNS
cord-264884-ydkigome	1089	6	:	:	:
cord-264884-ydkigome	1089	7	unique	unique	JJ
cord-264884-ydkigome	1089	8	viral	viral	JJ
cord-264884-ydkigome	1089	9	genomes	genome	NNS
cord-264884-ydkigome	1089	10	in	in	IN
cord-264884-ydkigome	1089	11	the	the	DT
cord-264884-ydkigome	1089	12	third	third	JJ
cord-264884-ydkigome	1089	13	domain	domain	NN
cord-264884-ydkigome	1089	14	of	of	IN
cord-264884-ydkigome	1089	15	life	life	NN
cord-264884-ydkigome	1089	16	ADP	ADP	NNP
cord-264884-ydkigome	1089	17	-	-	HYPH
cord-264884-ydkigome	1089	18	ribose-1	ribose-1	NNP
cord-264884-ydkigome	1090	1	"	"	``
cord-264884-ydkigome	1090	2	-monophosphatase	-monophosphatase	NN
cord-264884-ydkigome	1090	3	:	:	:
cord-264884-ydkigome	1091	1	a	a	DT
cord-264884-ydkigome	1091	2	conserved	conserved	JJ
cord-264884-ydkigome	1091	3	coronavirus	coronavirus	NN
cord-264884-ydkigome	1091	4	enzyme	enzyme	NN
cord-264884-ydkigome	1091	5	that	that	WDT
cord-264884-ydkigome	1091	6	is	be	VBZ
cord-264884-ydkigome	1091	7	dispensable	dispensable	JJ
cord-264884-ydkigome	1091	8	for	for	IN
cord-264884-ydkigome	1091	9	viral	viral	JJ
cord-264884-ydkigome	1091	10	replication	replication	NN
cord-264884-ydkigome	1091	11	in	in	IN
cord-264884-ydkigome	1091	12	tissue	tissue	NN
cord-264884-ydkigome	1091	13	culture	culture	NN
cord-264884-ydkigome	1092	1	Phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	1092	2	evidence	evidence	NN
cord-264884-ydkigome	1092	3	for	for	IN
cord-264884-ydkigome	1092	4	deleterious	deleterious	JJ
cord-264884-ydkigome	1092	5	mutation	mutation	NN
cord-264884-ydkigome	1092	6	load	load	NN
cord-264884-ydkigome	1092	7	in	in	IN
cord-264884-ydkigome	1092	8	RNA	RNA	NNP
cord-264884-ydkigome	1092	9	viruses	virus	NNS
cord-264884-ydkigome	1092	10	and	and	CC
cord-264884-ydkigome	1092	11	its	-PRON-	PRP$
cord-264884-ydkigome	1092	12	contribution	contribution	NN
cord-264884-ydkigome	1092	13	to	to	IN
cord-264884-ydkigome	1092	14	viral	viral	JJ
cord-264884-ydkigome	1092	15	evolution	evolution	NN
cord-264884-ydkigome	1092	16	Defective	defective	JJ
cord-264884-ydkigome	1092	17	interfering	interfere	VBG
cord-264884-ydkigome	1092	18	RNAs	rna	NNS
cord-264884-ydkigome	1092	19	of	of	IN
cord-264884-ydkigome	1092	20	a	a	DT
cord-264884-ydkigome	1092	21	satellite	satellite	NN
cord-264884-ydkigome	1092	22	virus	virus	NN
cord-264884-ydkigome	1092	23	Structural	structural	JJ
cord-264884-ydkigome	1092	24	proteomics	proteomic	NNS
cord-264884-ydkigome	1092	25	of	of	IN
cord-264884-ydkigome	1092	26	the	the	DT
cord-264884-ydkigome	1092	27	poxvirus	poxvirus	NNP
cord-264884-ydkigome	1092	28	family	family	NN
cord-264884-ydkigome	1093	1	The	the	DT
cord-264884-ydkigome	1093	2	1.2-megabase	1.2-megabase	CD
cord-264884-ydkigome	1093	3	genome	genome	NN
cord-264884-ydkigome	1093	4	sequence	sequence	NN
cord-264884-ydkigome	1093	5	of	of	IN
cord-264884-ydkigome	1093	6	Mimivirus	Mimivirus	NNP
cord-264884-ydkigome	1094	1	The	the	DT
cord-264884-ydkigome	1094	2	structure	structure	NN
cord-264884-ydkigome	1094	3	of	of	IN
cord-264884-ydkigome	1094	4	a	a	DT
cord-264884-ydkigome	1094	5	thermophilic	thermophilic	JJ
cord-264884-ydkigome	1094	6	archaeal	archaeal	JJ
cord-264884-ydkigome	1094	7	virus	virus	NN
cord-264884-ydkigome	1094	8	shows	show	VBZ
cord-264884-ydkigome	1094	9	a	a	DT
cord-264884-ydkigome	1094	10	double	double	RB
cord-264884-ydkigome	1094	11	-	-	HYPH
cord-264884-ydkigome	1094	12	stranded	strand	VBN
cord-264884-ydkigome	1094	13	DNA	dna	NN
cord-264884-ydkigome	1094	14	viral	viral	JJ
cord-264884-ydkigome	1094	15	capsid	capsid	NN
cord-264884-ydkigome	1094	16	type	type	NN
cord-264884-ydkigome	1094	17	that	that	WDT
cord-264884-ydkigome	1094	18	spans	span	VBZ
cord-264884-ydkigome	1094	19	all	all	DT
cord-264884-ydkigome	1094	20	domains	domain	NNS
cord-264884-ydkigome	1094	21	of	of	IN
cord-264884-ydkigome	1094	22	life	life	NN
cord-264884-ydkigome	1094	23	Plant	Plant	NNP
cord-264884-ydkigome	1094	24	RNA	RNA	NNP
cord-264884-ydkigome	1094	25	virus	virus	NN
cord-264884-ydkigome	1094	26	evolution	evolution	NN
cord-264884-ydkigome	1094	27	Symbiosis	Symbiosis	NNP
cord-264884-ydkigome	1094	28	versus	versus	IN
cord-264884-ydkigome	1094	29	competition	competition	NN
cord-264884-ydkigome	1094	30	in	in	IN
cord-264884-ydkigome	1094	31	plant	plant	NN
cord-264884-ydkigome	1094	32	virus	virus	NN
cord-264884-ydkigome	1094	33	evolution	evolution	NN
cord-264884-ydkigome	1094	34	Mutant	mutant	JJ
cord-264884-ydkigome	1094	35	clouds	cloud	NNS
cord-264884-ydkigome	1094	36	and	and	CC
cord-264884-ydkigome	1094	37	occupation	occupation	NN
cord-264884-ydkigome	1094	38	of	of	IN
cord-264884-ydkigome	1094	39	sequence	sequence	NN
cord-264884-ydkigome	1094	40	space	space	NN
cord-264884-ydkigome	1094	41	in	in	IN
cord-264884-ydkigome	1094	42	plant	plant	NN
cord-264884-ydkigome	1094	43	RNA	RNA	NNP
cord-264884-ydkigome	1094	44	viruses	virus	NNS
cord-264884-ydkigome	1094	45	Quasispecies	Quasispecies	NNP
cord-264884-ydkigome	1094	46	development	development	NN
cord-264884-ydkigome	1094	47	by	by	IN
cord-264884-ydkigome	1094	48	high	high	JJ
cord-264884-ydkigome	1094	49	frequency	frequency	NN
cord-264884-ydkigome	1094	50	RNA	RNA	NNP
cord-264884-ydkigome	1094	51	recombination	recombination	NN
cord-264884-ydkigome	1094	52	during	during	IN
cord-264884-ydkigome	1094	53	MHV	MHV	NNP
cord-264884-ydkigome	1094	54	persistence	persistence	NN
cord-264884-ydkigome	1094	55	Memory	memory	NN
cord-264884-ydkigome	1094	56	in	in	IN
cord-264884-ydkigome	1094	57	viral	viral	JJ
cord-264884-ydkigome	1094	58	quasispecies	quasispecie	NNS
cord-264884-ydkigome	1094	59	Viruses	virus	NNS
cord-264884-ydkigome	1094	60	as	as	IN
cord-264884-ydkigome	1094	61	symbionts	symbiont	NNS
cord-264884-ydkigome	1094	62	A	a	DT
cord-264884-ydkigome	1094	63	snapshot	snapshot	NN
cord-264884-ydkigome	1094	64	of	of	IN
cord-264884-ydkigome	1094	65	viral	viral	JJ
cord-264884-ydkigome	1094	66	evolution	evolution	NN
cord-264884-ydkigome	1094	67	from	from	IN
cord-264884-ydkigome	1094	68	genome	genome	NN
cord-264884-ydkigome	1094	69	analysis	analysis	NN
cord-264884-ydkigome	1094	70	of	of	IN
cord-264884-ydkigome	1094	71	the	the	DT
cord-264884-ydkigome	1094	72	tectiviridae	tectiviridae	NN
cord-264884-ydkigome	1094	73	family	family	NN
cord-264884-ydkigome	1094	74	Prevalence	prevalence	NN
cord-264884-ydkigome	1094	75	of	of	IN
cord-264884-ydkigome	1094	76	naturally	naturally	RB
cord-264884-ydkigome	1094	77	occurring	occur	VBG
cord-264884-ydkigome	1094	78	viral	viral	JJ
cord-264884-ydkigome	1094	79	infections	infection	NNS
cord-264884-ydkigome	1094	80	,	,	,
cord-264884-ydkigome	1094	81	Mycoplasma	Mycoplasma	NNP
cord-264884-ydkigome	1094	82	pulmonis	pulmonis	NN
cord-264884-ydkigome	1094	83	and	and	CC
cord-264884-ydkigome	1094	84	Clostridium	Clostridium	NNP
cord-264884-ydkigome	1094	85	piliforme	piliforme	NN
cord-264884-ydkigome	1094	86	in	in	IN
cord-264884-ydkigome	1094	87	laboratory	laboratory	NN
cord-264884-ydkigome	1094	88	rodents	rodent	NNS
cord-264884-ydkigome	1094	89	in	in	IN
cord-264884-ydkigome	1094	90	Western	Western	NNP
cord-264884-ydkigome	1094	91	Europe	Europe	NNP
cord-264884-ydkigome	1094	92	screened	screen	VBD
cord-264884-ydkigome	1094	93	from	from	IN
cord-264884-ydkigome	1094	94	Virus	virus	NN
cord-264884-ydkigome	1094	95	succession	succession	NN
cord-264884-ydkigome	1094	96	observed	observe	VBD
cord-264884-ydkigome	1094	97	during	during	IN
cord-264884-ydkigome	1094	98	an	an	DT
cord-264884-ydkigome	1094	99	Emiliania	Emiliania	NNP
cord-264884-ydkigome	1094	100	huxleyi	huxleyi	NN
cord-264884-ydkigome	1094	101	bloom	bloom	NN
cord-264884-ydkigome	1094	102	Phylogenetic	phylogenetic	JJ
cord-264884-ydkigome	1094	103	evidence	evidence	NN
cord-264884-ydkigome	1094	104	for	for	IN
cord-264884-ydkigome	1094	105	the	the	DT
cord-264884-ydkigome	1094	106	rapid	rapid	JJ
cord-264884-ydkigome	1094	107	evolution	evolution	NN
cord-264884-ydkigome	1094	108	of	of	IN
cord-264884-ydkigome	1094	109	human	human	JJ
cord-264884-ydkigome	1094	110	B19	B19	NNP
cord-264884-ydkigome	1094	111	erythrovirus	erythrovirus	NNP
cord-264884-ydkigome	1095	1	The	the	DT
cord-264884-ydkigome	1095	2	evolution	evolution	NN
cord-264884-ydkigome	1095	3	of	of	IN
cord-264884-ydkigome	1095	4	small	small	JJ
cord-264884-ydkigome	1095	5	DNA	dna	NN
cord-264884-ydkigome	1095	6	viruses	virus	NNS
cord-264884-ydkigome	1095	7	of	of	IN
cord-264884-ydkigome	1095	8	eukaryotes	eukaryote	NNS
cord-264884-ydkigome	1095	9	:	:	:
cord-264884-ydkigome	1096	1	Past	past	JJ
cord-264884-ydkigome	1096	2	and	and	CC
cord-264884-ydkigome	1096	3	present	present	JJ
cord-264884-ydkigome	1096	4	considerations	consideration	NNS
cord-264884-ydkigome	1096	5	Coinfection	Coinfection	NNP
cord-264884-ydkigome	1096	6	of	of	IN
cord-264884-ydkigome	1096	7	wild	wild	JJ
cord-264884-ydkigome	1096	8	ducks	duck	NNS
cord-264884-ydkigome	1096	9	by	by	IN
cord-264884-ydkigome	1096	10	infl	infl	NNP
cord-264884-ydkigome	1096	11	uenza	uenza	NNP
cord-264884-ydkigome	1096	12	a	a	DT
cord-264884-ydkigome	1096	13	viruses	virus	NNS
cord-264884-ydkigome	1096	14	:	:	:
cord-264884-ydkigome	1096	15	Distribution	distribution	NN
cord-264884-ydkigome	1096	16	patterns	pattern	NNS
cord-264884-ydkigome	1096	17	and	and	CC
cord-264884-ydkigome	1096	18	biological	biological	JJ
cord-264884-ydkigome	1096	19	signifi	signifi	NN
cord-264884-ydkigome	1096	20	cance	cance	NN
cord-264884-ydkigome	1096	21	Bacteriophage	Bacteriophage	NNP
cord-264884-ydkigome	1096	22	origins	origin	NNS
cord-264884-ydkigome	1096	23	of	of	IN
cord-264884-ydkigome	1096	24	mitochondrial	mitochondrial	JJ
cord-264884-ydkigome	1096	25	replication	replication	NN
cord-264884-ydkigome	1096	26	and	and	CC
cord-264884-ydkigome	1096	27	transcription	transcription	NN
cord-264884-ydkigome	1096	28	proteins	protein	NNS
cord-264884-ydkigome	1096	29	Plant	Plant	NNP
cord-264884-ydkigome	1096	30	virus	virus	NN
cord-264884-ydkigome	1096	31	satellite	satellite	NN
cord-264884-ydkigome	1096	32	and	and	CC
cord-264884-ydkigome	1096	33	defective	defective	JJ
cord-264884-ydkigome	1096	34	interfering	interfere	VBG
cord-264884-ydkigome	1096	35	RNAs	rna	NNS
cord-264884-ydkigome	1096	36	:	:	:
cord-264884-ydkigome	1096	37	new	new	JJ
cord-264884-ydkigome	1096	38	paradigms	paradigm	NNS
cord-264884-ydkigome	1096	39	for	for	IN
cord-264884-ydkigome	1096	40	a	a	DT
cord-264884-ydkigome	1096	41	new	new	JJ
cord-264884-ydkigome	1096	42	century	century	NN
cord-264884-ydkigome	1096	43	Prevalence	prevalence	NN
cord-264884-ydkigome	1096	44	of	of	IN
cord-264884-ydkigome	1096	45	viral	viral	JJ
cord-264884-ydkigome	1096	46	antibodies	antibody	NNS
cord-264884-ydkigome	1096	47	and	and	CC
cord-264884-ydkigome	1096	48	helminths	helminth	NNS
cord-264884-ydkigome	1096	49	in	in	IN
cord-264884-ydkigome	1096	50	fi	fi	NNP
cord-264884-ydkigome	1096	51	eld	eld	NNP
cord-264884-ydkigome	1096	52	populations	population	NNS
cord-264884-ydkigome	1096	53	of	of	IN
cord-264884-ydkigome	1096	54	house	house	NN
cord-264884-ydkigome	1096	55	mice	mouse	NNS
cord-264884-ydkigome	1096	56	(	(	-LRB-
cord-264884-ydkigome	1096	57	Mus	Mus	NNP
cord-264884-ydkigome	1096	58	domesticus	domesticus	NN
cord-264884-ydkigome	1096	59	)	)	-RRB-
cord-264884-ydkigome	1096	60	in	in	IN
cord-264884-ydkigome	1096	61	southeastern	southeastern	JJ
cord-264884-ydkigome	1096	62	Australia	Australia	NNP
cord-264884-ydkigome	1097	1	The	the	DT
cord-264884-ydkigome	1097	2	origin	origin	NN
cord-264884-ydkigome	1097	3	of	of	IN
cord-264884-ydkigome	1097	4	hepatitis	hepatitis	NNP
cord-264884-ydkigome	1097	5	C	C	NNP
cord-264884-ydkigome	1097	6	virus	virus	NN
cord-264884-ydkigome	1097	7	genotypes	genotype	NNS
cord-264884-ydkigome	1097	8	Emergence	emergence	NN
cord-264884-ydkigome	1097	9	and	and	CC
cord-264884-ydkigome	1097	10	predominance	predominance	NN
cord-264884-ydkigome	1097	11	of	of	IN
cord-264884-ydkigome	1097	12	an	an	DT
cord-264884-ydkigome	1097	13	H5N1	H5N1	NNP
cord-264884-ydkigome	1097	14	infl	infl	NN
cord-264884-ydkigome	1097	15	uenza	uenza	NN
cord-264884-ydkigome	1097	16	variant	variant	NN
cord-264884-ydkigome	1097	17	in	in	IN
cord-264884-ydkigome	1097	18	China	China	NNP
cord-264884-ydkigome	1097	19	Phylogenetic	Phylogenetic	NNP
cord-264884-ydkigome	1097	20	analyses	analysis	NNS
cord-264884-ydkigome	1097	21	of	of	IN
cord-264884-ydkigome	1097	22	type	type	NN
cord-264884-ydkigome	1097	23	A	a	DT
cord-264884-ydkigome	1097	24	infl	infl	NN
cord-264884-ydkigome	1097	25	uenza	uenza	NN
cord-264884-ydkigome	1097	26	genes	gene	NNS
cord-264884-ydkigome	1097	27	in	in	IN
cord-264884-ydkigome	1097	28	natural	natural	JJ
cord-264884-ydkigome	1097	29	reservoir	reservoir	NN
cord-264884-ydkigome	1097	30	species	specie	NNS
cord-264884-ydkigome	1097	31	in	in	IN
cord-264884-ydkigome	1097	32	North	North	NNP
cord-264884-ydkigome	1097	33	America	America	NNP
cord-264884-ydkigome	1097	34	reveals	reveal	VBZ
cord-264884-ydkigome	1097	35	genetic	genetic	JJ
cord-264884-ydkigome	1097	36	variation	variation	NN
cord-264884-ydkigome	1097	37	Dynamics	dynamic	NNS
cord-264884-ydkigome	1097	38	of	of	IN
cord-264884-ydkigome	1097	39	autocatalytic	autocatalytic	JJ
cord-264884-ydkigome	1097	40	replicator	replicator	NN
cord-264884-ydkigome	1097	41	networks	network	NNS
cord-264884-ydkigome	1097	42	based	base	VBN
cord-264884-ydkigome	1097	43	on	on	IN
cord-264884-ydkigome	1097	44	higher	high	JJR
cord-264884-ydkigome	1097	45	-	-	HYPH
cord-264884-ydkigome	1097	46	order	order	NN
cord-264884-ydkigome	1097	47	ligation	ligation	NN
cord-264884-ydkigome	1097	48	reactions	reaction	NNS
cord-264884-ydkigome	1097	49	Koala	Koala	NNP
cord-264884-ydkigome	1097	50	retrovirus	retrovirus	NN
cord-264884-ydkigome	1097	51	:	:	:
cord-264884-ydkigome	1097	52	a	a	DT
cord-264884-ydkigome	1097	53	genome	genome	NN
cord-264884-ydkigome	1097	54	invasion	invasion	NN
cord-264884-ydkigome	1097	55	in	in	IN
cord-264884-ydkigome	1097	56	real	real	JJ
cord-264884-ydkigome	1097	57	time	time	NN
cord-264884-ydkigome	1098	1	No	no	DT
cord-264884-ydkigome	1098	2	evidence	evidence	NN
cord-264884-ydkigome	1098	3	for	for	IN
cord-264884-ydkigome	1098	4	quasispecies	quasispecie	NNS
cord-264884-ydkigome	1098	5	populations	population	NNS
cord-264884-ydkigome	1098	6	during	during	IN
cord-264884-ydkigome	1098	7	persistence	persistence	NN
cord-264884-ydkigome	1098	8	of	of	IN
cord-264884-ydkigome	1098	9	the	the	DT
cord-264884-ydkigome	1098	10	coronavirus	coronavirus	NN
cord-264884-ydkigome	1098	11	mouse	mouse	NN
cord-264884-ydkigome	1098	12	hepatitis	hepatitis	NN
cord-264884-ydkigome	1098	13	virus	virus	NN
cord-264884-ydkigome	1098	14	JHM	JHM	NNP
cord-264884-ydkigome	1098	15	:	:	:
cord-264884-ydkigome	1098	16	sequence	sequence	NN
cord-264884-ydkigome	1098	17	conservation	conservation	NN
cord-264884-ydkigome	1098	18	within	within	IN
cord-264884-ydkigome	1098	19	the	the	DT
cord-264884-ydkigome	1098	20	surface	surface	NN
cord-264884-ydkigome	1098	21	glycoprotein	glycoprotein	NN
cord-264884-ydkigome	1098	22	gene	gene	NN
cord-264884-ydkigome	1098	23	S	S	NNP
cord-264884-ydkigome	1098	24	in	in	IN
cord-264884-ydkigome	1098	25	Lewis	Lewis	NNP
cord-264884-ydkigome	1098	26	rats	rat	NNS
cord-264884-ydkigome	1099	1	Evolution	evolution	NN
cord-264884-ydkigome	1099	2	of	of	IN
cord-264884-ydkigome	1099	3	avian	avian	JJ
cord-264884-ydkigome	1099	4	infl	infl	NN
cord-264884-ydkigome	1099	5	uenza	uenza	NN
cord-264884-ydkigome	1099	6	viruses	virus	NNS
cord-264884-ydkigome	1099	7	Prevalence	prevalence	NN
cord-264884-ydkigome	1099	8	and	and	CC
cord-264884-ydkigome	1099	9	evolution	evolution	NN
cord-264884-ydkigome	1099	10	of	of	IN
cord-264884-ydkigome	1099	11	core	core	NN
cord-264884-ydkigome	1099	12	photosystem	photosystem	NN
cord-264884-ydkigome	1099	13	II	II	NNP
cord-264884-ydkigome	1099	14	genes	gene	NNS
cord-264884-ydkigome	1099	15	in	in	IN
cord-264884-ydkigome	1099	16	marine	marine	JJ
cord-264884-ydkigome	1099	17	cyanobacterial	cyanobacterial	JJ
cord-264884-ydkigome	1099	18	viruses	virus	NNS
cord-264884-ydkigome	1099	19	and	and	CC
cord-264884-ydkigome	1099	20	their	-PRON-	PRP$
cord-264884-ydkigome	1099	21	hosts	host	NNS
cord-264884-ydkigome	1100	1	Ultrastructural	ultrastructural	JJ
cord-264884-ydkigome	1100	2	characterization	characterization	NN
cord-264884-ydkigome	1100	3	of	of	IN
cord-264884-ydkigome	1100	4	the	the	DT
cord-264884-ydkigome	1100	5	giant	giant	JJ
cord-264884-ydkigome	1100	6	volcano	volcano	NN
cord-264884-ydkigome	1100	7	-	-	HYPH
cord-264884-ydkigome	1100	8	like	like	JJ
cord-264884-ydkigome	1100	9	virus	virus	NN
cord-264884-ydkigome	1100	10	factory	factory	NN
cord-264884-ydkigome	1100	11	of	of	IN
cord-264884-ydkigome	1100	12	Acanthamoeba	Acanthamoeba	NNP
cord-264884-ydkigome	1100	13	polyphaga	polyphaga	NNP
cord-264884-ydkigome	1100	14	mimivirus	mimivirus	NNP
cord-264884-ydkigome	1100	15	Ancient	Ancient	NNP
cord-264884-ydkigome	1100	16	co	co	NN
cord-264884-ydkigome	1100	17	-	-	NN
cord-264884-ydkigome	1100	18	speciation	speciation	NN
cord-264884-ydkigome	1100	19	of	of	IN
cord-264884-ydkigome	1100	20	simian	simian	JJ
cord-264884-ydkigome	1100	21	foamy	foamy	NN
cord-264884-ydkigome	1100	22	viruses	virus	NNS
cord-264884-ydkigome	1100	23	and	and	CC
cord-264884-ydkigome	1100	24	primates	primate	NNS
cord-264884-ydkigome	1100	25	Poxviruses	Poxviruses	NNPS
cord-264884-ydkigome	1100	26	and	and	CC
cord-264884-ydkigome	1100	27	the	the	DT
cord-264884-ydkigome	1100	28	origin	origin	NN
cord-264884-ydkigome	1100	29	of	of	IN
cord-264884-ydkigome	1100	30	the	the	DT
cord-264884-ydkigome	1100	31	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	1100	32	nucleus	nucleus	NN
cord-264884-ydkigome	1100	33	Prevalence	prevalence	NN
cord-264884-ydkigome	1100	34	and	and	CC
cord-264884-ydkigome	1100	35	genetic	genetic	JJ
cord-264884-ydkigome	1100	36	diversity	diversity	NN
cord-264884-ydkigome	1100	37	of	of	IN
cord-264884-ydkigome	1100	38	coronaviruses	coronaviruse	NNS
cord-264884-ydkigome	1100	39	in	in	IN
cord-264884-ydkigome	1100	40	bats	bat	NNS
cord-264884-ydkigome	1100	41	from	from	IN
cord-264884-ydkigome	1100	42	A	a	DT
cord-264884-ydkigome	1100	43	mutation	mutation	NN
cord-264884-ydkigome	1100	44	in	in	IN
cord-264884-ydkigome	1100	45	the	the	DT
cord-264884-ydkigome	1100	46	RNA	RNA	NNP
cord-264884-ydkigome	1100	47	polymerase	polymerase	NN
cord-264884-ydkigome	1100	48	of	of	IN
cord-264884-ydkigome	1100	49	poliovirus	poliovirus	NN
cord-264884-ydkigome	1100	50	type	type	NN
cord-264884-ydkigome	1100	51	1	1	CD
cord-264884-ydkigome	1100	52	contributes	contribute	VBZ
cord-264884-ydkigome	1100	53	to	to	IN
cord-264884-ydkigome	1100	54	attenuation	attenuation	NN
cord-264884-ydkigome	1100	55	in	in	IN
cord-264884-ydkigome	1100	56	mice	mouse	NNS
cord-264884-ydkigome	1100	57	Retroviral	retroviral	JJ
cord-264884-ydkigome	1100	58	invasion	invasion	NN
cord-264884-ydkigome	1100	59	of	of	IN
cord-264884-ydkigome	1100	60	the	the	DT
cord-264884-ydkigome	1100	61	koala	koala	NN
cord-264884-ydkigome	1100	62	genome	genome	NN
cord-264884-ydkigome	1100	63	Unusual	unusual	JJ
cord-264884-ydkigome	1100	64	life	life	NN
cord-264884-ydkigome	1100	65	style	style	NN
cord-264884-ydkigome	1100	66	of	of	IN
cord-264884-ydkigome	1100	67	giant	giant	JJ
cord-264884-ydkigome	1100	68	chlorella	chlorella	NN
cord-264884-ydkigome	1100	69	viruses	virus	NNS
cord-264884-ydkigome	1101	1	Phycodnaviridae	phycodnaviridae	NN
cord-264884-ydkigome	1101	2	-	-	HYPH
cord-264884-ydkigome	1101	3	large	large	JJ
cord-264884-ydkigome	1101	4	DNA	dna	NN
cord-264884-ydkigome	1101	5	algal	algal	NN
cord-264884-ydkigome	1101	6	viruses	virus	NNS
cord-264884-ydkigome	1102	1	Collective	collective	JJ
cord-264884-ydkigome	1102	2	evolution	evolution	NN
cord-264884-ydkigome	1102	3	and	and	CC
cord-264884-ydkigome	1102	4	the	the	DT
cord-264884-ydkigome	1102	5	genetic	genetic	JJ
cord-264884-ydkigome	1102	6	code	code	NN
cord-264884-ydkigome	1102	7	Ribavirin	ribavirin	NN
cord-264884-ydkigome	1102	8	and	and	CC
cord-264884-ydkigome	1102	9	lethal	lethal	JJ
cord-264884-ydkigome	1102	10	mutagenesis	mutagenesis	NN
cord-264884-ydkigome	1102	11	of	of	IN
cord-264884-ydkigome	1102	12	poliovirus	poliovirus	NN
cord-264884-ydkigome	1102	13	:	:	:
cord-264884-ydkigome	1102	14	molecular	molecular	JJ
cord-264884-ydkigome	1102	15	mechanisms	mechanism	NNS
cord-264884-ydkigome	1102	16	,	,	,
cord-264884-ydkigome	1102	17	resistance	resistance	NN
cord-264884-ydkigome	1102	18	and	and	CC
cord-264884-ydkigome	1102	19	biological	biological	JJ
cord-264884-ydkigome	1102	20	implications	implication	NNS
cord-264884-ydkigome	1103	1	Quasispecies	Quasispecies	NNP
cord-264884-ydkigome	1103	2	diversity	diversity	NN
cord-264884-ydkigome	1103	3	determines	determine	VBZ
cord-264884-ydkigome	1103	4	pathogenesis	pathogenesis	NN
cord-264884-ydkigome	1103	5	through	through	IN
cord-264884-ydkigome	1103	6	cooperative	cooperative	JJ
cord-264884-ydkigome	1103	7	interactions	interaction	NNS
cord-264884-ydkigome	1103	8	in	in	IN
cord-264884-ydkigome	1103	9	a	a	DT
cord-264884-ydkigome	1103	10	viral	viral	JJ
cord-264884-ydkigome	1103	11	population	population	NN
cord-264884-ydkigome	1103	12	Evolutionary	evolutionary	JJ
cord-264884-ydkigome	1103	13	insights	insight	NNS
cord-264884-ydkigome	1103	14	into	into	IN
cord-264884-ydkigome	1103	15	the	the	DT
cord-264884-ydkigome	1103	16	ecology	ecology	NN
cord-264884-ydkigome	1103	17	of	of	IN
cord-264884-ydkigome	1103	18	coronaviruses	coronaviruse	NNS
cord-264884-ydkigome	1103	19	DNA	DNA	NNP
cord-264884-ydkigome	1103	20	virus	virus	NN
cord-264884-ydkigome	1103	21	contribution	contribution	NN
cord-264884-ydkigome	1103	22	to	to	TO
cord-264884-ydkigome	1103	23	host	host	VB
cord-264884-ydkigome	1103	24	evolution	evolution	NN
cord-264884-ydkigome	1103	25	Viruses	virus	NNS
cord-264884-ydkigome	1103	26	and	and	CC
cord-264884-ydkigome	1103	27	the	the	DT
cord-264884-ydkigome	1103	28	Evolution	Evolution	NNP
cord-264884-ydkigome	1103	29	of	of	IN
cord-264884-ydkigome	1103	30	Life	Life	NNP
cord-264884-ydkigome	1104	1	How	how	WRB
cord-264884-ydkigome	1104	2	viruses	virus	NNS
cord-264884-ydkigome	1104	3	shape	shape	VBP
cord-264884-ydkigome	1104	4	the	the	DT
cord-264884-ydkigome	1104	5	tree	tree	NN
cord-264884-ydkigome	1104	6	of	of	IN
cord-264884-ydkigome	1104	7	life	life	NN
cord-264884-ydkigome	1104	8	Virus	Virus	NNP
cord-264884-ydkigome	1104	9	-	-	HYPH
cord-264884-ydkigome	1104	10	host	host	NN
cord-264884-ydkigome	1104	11	symbiosis	symbiosis	NN
cord-264884-ydkigome	1104	12	mediated	mediate	VBN
cord-264884-ydkigome	1104	13	by	by	IN
cord-264884-ydkigome	1104	14	persistence	persistence	NN
cord-264884-ydkigome	1104	15	A	a	DT
cord-264884-ydkigome	1104	16	hypothesis	hypothesis	NN
cord-264884-ydkigome	1104	17	for	for	IN
cord-264884-ydkigome	1104	18	DNA	dna	NN
cord-264884-ydkigome	1104	19	viruses	virus	NNS
cord-264884-ydkigome	1104	20	as	as	IN
cord-264884-ydkigome	1104	21	the	the	DT
cord-264884-ydkigome	1104	22	origin	origin	NN
cord-264884-ydkigome	1104	23	of	of	IN
cord-264884-ydkigome	1104	24	eukaryotic	eukaryotic	JJ
cord-264884-ydkigome	1104	25	replication	replication	NN
cord-264884-ydkigome	1104	26	proteins	protein	NNS
cord-264884-ydkigome	1104	27	On	on	IN
cord-264884-ydkigome	1104	28	viruses	virus	NNS
cord-264884-ydkigome	1104	29	,	,	,
cord-264884-ydkigome	1104	30	sex	sex	NN
cord-264884-ydkigome	1104	31	and	and	CC
cord-264884-ydkigome	1104	32	motherhood	motherhood	NN
cord-264884-ydkigome	1104	33	Acute	acute	JJ
cord-264884-ydkigome	1104	34	and	and	CC
cord-264884-ydkigome	1104	35	persistent	persistent	JJ
cord-264884-ydkigome	1104	36	viral	viral	JJ
cord-264884-ydkigome	1104	37	life	life	NN
cord-264884-ydkigome	1104	38	strategies	strategy	NNS
cord-264884-ydkigome	1104	39	and	and	CC
cord-264884-ydkigome	1104	40	their	-PRON-	PRP$
cord-264884-ydkigome	1104	41	relationship	relationship	NN
cord-264884-ydkigome	1104	42	to	to	IN
cord-264884-ydkigome	1104	43	emerging	emerge	VBG
cord-264884-ydkigome	1104	44	diseases	disease	NNS
cord-264884-ydkigome	1104	45	Major	major	JJ
cord-264884-ydkigome	1104	46	histocompatibility	histocompatibility	NN
cord-264884-ydkigome	1104	47	complex	complex	NN
cord-264884-ydkigome	1104	48	class	class	NN
cord-264884-ydkigome	1105	1	I	-PRON-	PRP
cord-264884-ydkigome	1105	2	genes	gene	NNS
cord-264884-ydkigome	1105	3	in	in	IN
cord-264884-ydkigome	1105	4	primates	primate	NNS
cord-264884-ydkigome	1105	5	:	:	:
cord-264884-ydkigome	1105	6	co	co	NN
cord-264884-ydkigome	1105	7	-	-	NN
cord-264884-ydkigome	1105	8	evolution	evolution	NN
cord-264884-ydkigome	1105	9	with	with	IN
cord-264884-ydkigome	1105	10	pathogens	pathogen	NNS
cord-264884-ydkigome	1106	1	High	high	JJ
cord-264884-ydkigome	1106	2	prevalence	prevalence	NN
cord-264884-ydkigome	1106	3	of	of	IN
cord-264884-ydkigome	1106	4	infl	infl	NN
cord-264884-ydkigome	1106	5	uenza	uenza	NNP
cord-264884-ydkigome	1106	6	A	a	DT
cord-264884-ydkigome	1106	7	virus	virus	NN
cord-264884-ydkigome	1106	8	in	in	IN
cord-264884-ydkigome	1106	9	ducks	duck	NNS
cord-264884-ydkigome	1106	10	caught	catch	VBN
cord-264884-ydkigome	1106	11	during	during	IN
cord-264884-ydkigome	1106	12	spring	spring	NN
cord-264884-ydkigome	1106	13	migration	migration	NN
cord-264884-ydkigome	1106	14	through	through	IN
cord-264884-ydkigome	1106	15	Sweden	Sweden	NNP
cord-264884-ydkigome	1106	16	First	First	NNP
cord-264884-ydkigome	1106	17	demonstration	demonstration	NN
cord-264884-ydkigome	1106	18	of	of	IN
cord-264884-ydkigome	1106	19	a	a	DT
cord-264884-ydkigome	1106	20	lack	lack	NN
cord-264884-ydkigome	1106	21	of	of	IN
cord-264884-ydkigome	1106	22	viral	viral	JJ
cord-264884-ydkigome	1106	23	sequence	sequence	NN
cord-264884-ydkigome	1106	24	evolution	evolution	NN
cord-264884-ydkigome	1106	25	in	in	IN
cord-264884-ydkigome	1106	26	a	a	DT
cord-264884-ydkigome	1106	27	nonprogressor	nonprogressor	NN
cord-264884-ydkigome	1106	28	,	,	,
cord-264884-ydkigome	1106	29	defi	defi	NNP
cord-264884-ydkigome	1106	30	ning	ning	NNP
cord-264884-ydkigome	1106	31	replication	replication	NN
cord-264884-ydkigome	1106	32	-	-	HYPH
cord-264884-ydkigome	1106	33	incompetent	incompetent	JJ
cord-264884-ydkigome	1106	34	HIV-1	HIV-1	NNP
cord-264884-ydkigome	1106	35	infection	infection	NN
cord-264884-ydkigome	1106	36	Phylogenetic	Phylogenetic	NNP
cord-264884-ydkigome	1106	37	analysis	analysis	NN
cord-264884-ydkigome	1106	38	,	,	,
cord-264884-ydkigome	1106	39	genome	genome	NN
cord-264884-ydkigome	1106	40	evolution	evolution	NN
cord-264884-ydkigome	1106	41	and	and	CC
cord-264884-ydkigome	1106	42	the	the	DT
cord-264884-ydkigome	1106	43	rate	rate	NN
cord-264884-ydkigome	1106	44	of	of	IN
cord-264884-ydkigome	1106	45	gene	gene	NN
cord-264884-ydkigome	1106	46	gain	gain	NN
cord-264884-ydkigome	1106	47	in	in	IN
cord-264884-ydkigome	1106	48	the	the	DT
cord-264884-ydkigome	1106	49	Herpesviridae	Herpesviridae	NNP
cord-264884-ydkigome	1107	1	The	the	DT
cord-264884-ydkigome	1107	2	evolution	evolution	NN
cord-264884-ydkigome	1107	3	of	of	IN
cord-264884-ydkigome	1107	4	major	major	JJ
cord-264884-ydkigome	1107	5	histocompatibility	histocompatibility	NN
cord-264884-ydkigome	1107	6	class	class	NN
cord-264884-ydkigome	1107	7	I	-PRON-	PRP
cord-264884-ydkigome	1107	8	genes	gene	NNS
cord-264884-ydkigome	1107	9	in	in	IN
cord-264884-ydkigome	1107	10	primates	primate	NNS
cord-264884-ydkigome	1107	11	H5N1	H5N1	NNP
cord-264884-ydkigome	1107	12	infl	infl	XX
cord-264884-ydkigome	1107	13	uenza	uenza	RB
cord-264884-ydkigome	1107	14	-	-	:
cord-264884-ydkigome	1107	15	continuing	continue	VBG
cord-264884-ydkigome	1107	16	evolution	evolution	NN
cord-264884-ydkigome	1107	17	and	and	CC
cord-264884-ydkigome	1107	18	spread	spread	VBD
cord-264884-ydkigome	1107	19	Elimination	Elimination	NNP
cord-264884-ydkigome	1107	20	of	of	IN
cord-264884-ydkigome	1107	21	mouse	mouse	NN
cord-264884-ydkigome	1107	22	hepatitis	hepatitis	NN
cord-264884-ydkigome	1107	23	virus	virus	NN
cord-264884-ydkigome	1107	24	from	from	IN
cord-264884-ydkigome	1107	25	a	a	DT
cord-264884-ydkigome	1107	26	breeding	breeding	NN
cord-264884-ydkigome	1107	27	colony	colony	NN
cord-264884-ydkigome	1107	28	by	by	IN
cord-264884-ydkigome	1107	29	temporary	temporary	JJ
cord-264884-ydkigome	1107	30	cessation	cessation	NN
cord-264884-ydkigome	1107	31	of	of	IN
cord-264884-ydkigome	1107	32	breeding	breed	VBG
cord-264884-ydkigome	1107	33	Matrix	Matrix	NNP
cord-264884-ydkigome	1107	34	gene	gene	NN
cord-264884-ydkigome	1107	35	of	of	IN
cord-264884-ydkigome	1107	36	infl	infl	NNP
cord-264884-ydkigome	1107	37	uenza	uenza	NNP
cord-264884-ydkigome	1107	38	a	a	DT
cord-264884-ydkigome	1107	39	viruses	virus	NNS
cord-264884-ydkigome	1107	40	isolated	isolate	VBN
cord-264884-ydkigome	1107	41	from	from	IN
cord-264884-ydkigome	1107	42	wild	wild	JJ
cord-264884-ydkigome	1107	43	aquatic	aquatic	JJ
cord-264884-ydkigome	1107	44	birds	bird	NNS
cord-264884-ydkigome	1107	45	:	:	:
cord-264884-ydkigome	1108	1	Ecology	ecology	NN
cord-264884-ydkigome	1108	2	and	and	CC
cord-264884-ydkigome	1108	3	emergence	emergence	NN
cord-264884-ydkigome	1108	4	of	of	IN
cord-264884-ydkigome	1108	5	infl	infl	NN
cord-264884-ydkigome	1108	6	uenza	uenza	NNP
cord-264884-ydkigome	1108	7	A	a	DT
cord-264884-ydkigome	1108	8	viruses	virus	NNS
cord-264884-ydkigome	1108	9	Persistent	persistent	JJ
cord-264884-ydkigome	1108	10	MHV	MHV	NNP
cord-264884-ydkigome	1108	11	(	(	-LRB-
cord-264884-ydkigome	1108	12	mouse	mouse	NN
cord-264884-ydkigome	1108	13	hepatitis	hepatitis	NN
cord-264884-ydkigome	1108	14	virus	virus	NN
cord-264884-ydkigome	1108	15	)	)	-RRB-
cord-264884-ydkigome	1108	16	infection	infection	NN
cord-264884-ydkigome	1108	17	reduces	reduce	VBZ
cord-264884-ydkigome	1108	18	the	the	DT
cord-264884-ydkigome	1108	19	incidence	incidence	NN
cord-264884-ydkigome	1108	20	of	of	IN
cord-264884-ydkigome	1108	21	diabetes	diabetes	NN
cord-264884-ydkigome	1108	22	mellitus	mellitus	NN
cord-264884-ydkigome	1108	23	in	in	IN
cord-264884-ydkigome	1108	24	non	non	JJ
cord-264884-ydkigome	1108	25	-	-	JJ
cord-264884-ydkigome	1108	26	obese	obese	JJ
cord-264884-ydkigome	1108	27	diabetic	diabetic	JJ
cord-264884-ydkigome	1108	28	mice	mouse	NNS
cord-264884-ydkigome	1108	29	Long	long	JJ
cord-264884-ydkigome	1108	30	intervals	interval	NNS
cord-264884-ydkigome	1108	31	of	of	IN
cord-264884-ydkigome	1108	32	stasis	stasis	NN
cord-264884-ydkigome	1108	33	punctuated	punctuate	VBN
cord-264884-ydkigome	1108	34	by	by	IN
cord-264884-ydkigome	1108	35	bursts	burst	NNS
cord-264884-ydkigome	1108	36	of	of	IN
cord-264884-ydkigome	1108	37	positive	positive	JJ
cord-264884-ydkigome	1108	38	selection	selection	NN
cord-264884-ydkigome	1108	39	in	in	IN
cord-264884-ydkigome	1108	40	the	the	DT
cord-264884-ydkigome	1108	41	seasonal	seasonal	JJ
cord-264884-ydkigome	1108	42	evolution	evolution	NN
cord-264884-ydkigome	1108	43	of	of	IN
cord-264884-ydkigome	1108	44	infl	infl	NN
cord-264884-ydkigome	1108	45	uenza	uenza	NNP
cord-264884-ydkigome	1108	46	A	a	DT
cord-264884-ydkigome	1108	47	virus	virus	NN
cord-264884-ydkigome	1108	48	Bacteriophage	bacteriophage	NN
cord-264884-ydkigome	1108	49	P1	P1	NNP
cord-264884-ydkigome	1108	50	in	in	IN
cord-264884-ydkigome	1108	51	retrospect	retrospect	NN
cord-264884-ydkigome	1108	52	and	and	CC
cord-264884-ydkigome	1108	53	in	in	IN
cord-264884-ydkigome	1108	54	prospect	prospect	JJ
cord-264884-ydkigome	1108	55	Human	human	JJ
cord-264884-ydkigome	1108	56	endogenous	endogenous	JJ
cord-264884-ydkigome	1108	57	retroviral	retroviral	NN
cord-264884-ydkigome	1108	58	elements	element	NNS
cord-264884-ydkigome	1108	59	belonging	belong	VBG
cord-264884-ydkigome	1108	60	to	to	IN
cord-264884-ydkigome	1108	61	the	the	DT
cord-264884-ydkigome	1108	62	HERV	HERV	NNP
cord-264884-ydkigome	1108	63	-	-	HYPH
cord-264884-ydkigome	1108	64	S	S	NNP
cord-264884-ydkigome	1108	65	family	family	NN
cord-264884-ydkigome	1108	66	from	from	IN
cord-264884-ydkigome	1108	67	human	human	JJ
cord-264884-ydkigome	1108	68	tissues	tissue	NNS
cord-264884-ydkigome	1108	69	,	,	,
cord-264884-ydkigome	1108	70	cancer	cancer	NN
cord-264884-ydkigome	1108	71	cells	cell	NNS
cord-264884-ydkigome	1108	72	and	and	CC
cord-264884-ydkigome	1108	73	primates	primate	NNS
cord-264884-ydkigome	1108	74	:	:	:
cord-264884-ydkigome	1108	75	expression	expression	NN
cord-264884-ydkigome	1108	76	,	,	,
cord-264884-ydkigome	1108	77	structure	structure	NN
cord-264884-ydkigome	1108	78	,	,	,
cord-264884-ydkigome	1108	79	phylogeny	phylogeny	NN
cord-264884-ydkigome	1108	80	and	and	CC
cord-264884-ydkigome	1108	81	evolution	evolution	NN
cord-264884-ydkigome	1108	82	A	a	DT
cord-264884-ydkigome	1108	83	reevaluation	reevaluation	NN
cord-264884-ydkigome	1108	84	of	of	IN
cord-264884-ydkigome	1108	85	the	the	DT
cord-264884-ydkigome	1108	86	higher	high	JJR
cord-264884-ydkigome	1108	87	taxonomy	taxonomy	NN
cord-264884-ydkigome	1108	88	of	of	IN
cord-264884-ydkigome	1108	89	viruses	virus	NNS
cord-264884-ydkigome	1108	90	based	base	VBN
cord-264884-ydkigome	1108	91	on	on	IN
cord-264884-ydkigome	1108	92	RNA	RNA	NNP
cord-264884-ydkigome	1108	93	polymerases	polymerase	NNS
cord-264884-ydkigome	1109	1	Chlorella	chlorella	NN
cord-264884-ydkigome	1109	2	virus	virus	NN
cord-264884-ydkigome	1109	3	-	-	HYPH
cord-264884-ydkigome	1109	4	encoded	encode	VBN
cord-264884-ydkigome	1109	5	deoxyuridine	deoxyuridine	NN
cord-264884-ydkigome	1109	6	triphosphatases	triphosphatase	NNS
cord-264884-ydkigome	1109	7	exhibit	exhibit	VBP
cord-264884-ydkigome	1109	8	different	different	JJ
cord-264884-ydkigome	1109	9	temperature	temperature	NN
cord-264884-ydkigome	1109	10	optima	optima	NNP
cord-264884-ydkigome	1109	11	Persistence	Persistence	NNP
cord-264884-ydkigome	1109	12	of	of	IN
cord-264884-ydkigome	1109	13	extraordinarily	extraordinarily	RB
cord-264884-ydkigome	1109	14	low	low	JJ
cord-264884-ydkigome	1109	15	levels	level	NNS
cord-264884-ydkigome	1109	16	of	of	IN
cord-264884-ydkigome	1109	17	genetically	genetically	RB
cord-264884-ydkigome	1109	18	homogeneous	homogeneous	JJ
cord-264884-ydkigome	1109	19	human	human	JJ
cord-264884-ydkigome	1109	20	immunodefi	immunodefi	NNP
cord-264884-ydkigome	1109	21	ciency	ciency	NNP
cord-264884-ydkigome	1109	22	virus	virus	NN
cord-264884-ydkigome	1109	23	type	type	NN
cord-264884-ydkigome	1109	24	1	1	CD
cord-264884-ydkigome	1109	25	in	in	IN
cord-264884-ydkigome	1109	26	exposed	expose	VBN
cord-264884-ydkigome	1109	27	seronegative	seronegative	JJ
cord-264884-ydkigome	1109	28	individuals	individual	NNS