id sid tid token lemma pos cord-104317-t30dg6oj 1 1 key key JJ cord-104317-t30dg6oj 1 2 : : : cord-104317-t30dg6oj 1 3 cord-104317-t30dg6oj cord-104317-t30dg6oj NNS cord-104317-t30dg6oj 1 4 authors author NNS cord-104317-t30dg6oj 1 5 : : : cord-104317-t30dg6oj 1 6 Parker Parker NNP cord-104317-t30dg6oj 1 7 , , , cord-104317-t30dg6oj 1 8 Michael Michael NNP cord-104317-t30dg6oj 1 9 T. T. NNP cord-104317-t30dg6oj 1 10 title title NN cord-104317-t30dg6oj 1 11 : : : cord-104317-t30dg6oj 2 1 An an DT cord-104317-t30dg6oj 2 2 Ecological Ecological NNP cord-104317-t30dg6oj 2 3 Framework Framework NNP cord-104317-t30dg6oj 2 4 of of IN cord-104317-t30dg6oj 2 5 the the DT cord-104317-t30dg6oj 2 6 Human Human NNP cord-104317-t30dg6oj 2 7 Virome Virome NNP cord-104317-t30dg6oj 2 8 Provides provide VBZ cord-104317-t30dg6oj 2 9 Classification Classification NNP cord-104317-t30dg6oj 2 10 of of IN cord-104317-t30dg6oj 2 11 Current Current NNP cord-104317-t30dg6oj 2 12 Knowledge Knowledge NNP cord-104317-t30dg6oj 2 13 and and CC cord-104317-t30dg6oj 2 14 Identifies identify VBZ cord-104317-t30dg6oj 2 15 Areas Areas NNP cord-104317-t30dg6oj 2 16 of of IN cord-104317-t30dg6oj 2 17 Forthcoming Forthcoming NNP cord-104317-t30dg6oj 2 18 Discovery Discovery NNP cord-104317-t30dg6oj 2 19 date date NN cord-104317-t30dg6oj 3 1 : : : cord-104317-t30dg6oj 3 2 2016 2016 CD cord-104317-t30dg6oj 3 3 - - HYPH cord-104317-t30dg6oj 3 4 09 09 CD cord-104317-t30dg6oj 3 5 - - SYM cord-104317-t30dg6oj 3 6 30 30 CD cord-104317-t30dg6oj 3 7 journal journal NN cord-104317-t30dg6oj 3 8 : : : cord-104317-t30dg6oj 4 1 Yale Yale NNP cord-104317-t30dg6oj 4 2 J J NNP cord-104317-t30dg6oj 4 3 Biol Biol NNP cord-104317-t30dg6oj 4 4 Med Med NNP cord-104317-t30dg6oj 4 5 DOI DOI NNP cord-104317-t30dg6oj 4 6 : : : cord-104317-t30dg6oj 4 7 nan nan NNP cord-104317-t30dg6oj 4 8 sha sha NNP cord-104317-t30dg6oj 4 9 : : : cord-104317-t30dg6oj 5 1 40470023462dcfcc8ed653d73a5dd255699abcad 40470023462dcfcc8ed653d73a5dd255699abcad CD cord-104317-t30dg6oj 5 2 doc_id doc_id CD cord-104317-t30dg6oj 6 1 : : : cord-104317-t30dg6oj 6 2 104317 104317 CD cord-104317-t30dg6oj 6 3 cord_uid cord_uid NNS cord-104317-t30dg6oj 6 4 : : : cord-104317-t30dg6oj 6 5 t30dg6oj t30dg6oj NNP cord-104317-t30dg6oj 7 1 Recent recent JJ cord-104317-t30dg6oj 7 2 advances advance NNS cord-104317-t30dg6oj 7 3 in in IN cord-104317-t30dg6oj 7 4 sequencing sequencing NN cord-104317-t30dg6oj 7 5 technologies technology NNS cord-104317-t30dg6oj 7 6 have have VBP cord-104317-t30dg6oj 7 7 opened open VBN cord-104317-t30dg6oj 7 8 the the DT cord-104317-t30dg6oj 7 9 door door NN cord-104317-t30dg6oj 7 10 for for IN cord-104317-t30dg6oj 7 11 the the DT cord-104317-t30dg6oj 7 12 classification classification NN cord-104317-t30dg6oj 7 13 of of IN cord-104317-t30dg6oj 7 14 the the DT cord-104317-t30dg6oj 7 15 human human JJ cord-104317-t30dg6oj 7 16 virome virome NN cord-104317-t30dg6oj 7 17 . . . cord-104317-t30dg6oj 8 1 While while IN cord-104317-t30dg6oj 8 2 taxonomic taxonomic JJ cord-104317-t30dg6oj 8 3 classification classification NN cord-104317-t30dg6oj 8 4 can can MD cord-104317-t30dg6oj 8 5 be be VB cord-104317-t30dg6oj 8 6 applied apply VBN cord-104317-t30dg6oj 8 7 to to IN cord-104317-t30dg6oj 8 8 the the DT cord-104317-t30dg6oj 8 9 viruses virus NNS cord-104317-t30dg6oj 8 10 identified identify VBN cord-104317-t30dg6oj 8 11 in in IN cord-104317-t30dg6oj 8 12 such such JJ cord-104317-t30dg6oj 8 13 studies study NNS cord-104317-t30dg6oj 8 14 , , , cord-104317-t30dg6oj 8 15 this this DT cord-104317-t30dg6oj 8 16 gives give VBZ cord-104317-t30dg6oj 8 17 no no DT cord-104317-t30dg6oj 8 18 information information NN cord-104317-t30dg6oj 8 19 as as IN cord-104317-t30dg6oj 8 20 to to IN cord-104317-t30dg6oj 8 21 the the DT cord-104317-t30dg6oj 8 22 type type NN cord-104317-t30dg6oj 8 23 of of IN cord-104317-t30dg6oj 8 24 interaction interaction NN cord-104317-t30dg6oj 8 25 the the DT cord-104317-t30dg6oj 8 26 virus virus NN cord-104317-t30dg6oj 8 27 has have VBZ cord-104317-t30dg6oj 8 28 with with IN cord-104317-t30dg6oj 8 29 the the DT cord-104317-t30dg6oj 8 30 host host NN cord-104317-t30dg6oj 8 31 . . . cord-104317-t30dg6oj 9 1 As as IN cord-104317-t30dg6oj 9 2 follow follow VB cord-104317-t30dg6oj 9 3 - - HYPH cord-104317-t30dg6oj 9 4 up up RP cord-104317-t30dg6oj 9 5 studies study NNS cord-104317-t30dg6oj 9 6 are be VBP cord-104317-t30dg6oj 9 7 performed perform VBN cord-104317-t30dg6oj 9 8 to to TO cord-104317-t30dg6oj 9 9 address address VB cord-104317-t30dg6oj 9 10 these these DT cord-104317-t30dg6oj 9 11 questions question NNS cord-104317-t30dg6oj 9 12 , , , cord-104317-t30dg6oj 9 13 the the DT cord-104317-t30dg6oj 9 14 description description NN cord-104317-t30dg6oj 9 15 of of IN cord-104317-t30dg6oj 9 16 these these DT cord-104317-t30dg6oj 9 17 virus virus NN cord-104317-t30dg6oj 9 18 - - HYPH cord-104317-t30dg6oj 9 19 host host NN cord-104317-t30dg6oj 9 20 interactions interaction NNS cord-104317-t30dg6oj 9 21 would would MD cord-104317-t30dg6oj 9 22 be be VB cord-104317-t30dg6oj 9 23 greatly greatly RB cord-104317-t30dg6oj 9 24 enriched enrich VBN cord-104317-t30dg6oj 9 25 by by IN cord-104317-t30dg6oj 9 26 applying apply VBG cord-104317-t30dg6oj 9 27 a a DT cord-104317-t30dg6oj 9 28 standard standard JJ cord-104317-t30dg6oj 9 29 set set NN cord-104317-t30dg6oj 9 30 of of IN cord-104317-t30dg6oj 9 31 definitions definition NNS cord-104317-t30dg6oj 9 32 that that WDT cord-104317-t30dg6oj 9 33 typify typify VBP cord-104317-t30dg6oj 9 34 them -PRON- PRP cord-104317-t30dg6oj 9 35 . . . cord-104317-t30dg6oj 10 1 This this DT cord-104317-t30dg6oj 10 2 paper paper NN cord-104317-t30dg6oj 10 3 describes describe VBZ cord-104317-t30dg6oj 10 4 a a DT cord-104317-t30dg6oj 10 5 framework framework NN cord-104317-t30dg6oj 10 6 with with IN cord-104317-t30dg6oj 10 7 which which WDT cord-104317-t30dg6oj 10 8 all all DT cord-104317-t30dg6oj 10 9 members member NNS cord-104317-t30dg6oj 10 10 of of IN cord-104317-t30dg6oj 10 11 the the DT cord-104317-t30dg6oj 10 12 human human JJ cord-104317-t30dg6oj 10 13 virome virome NN cord-104317-t30dg6oj 10 14 can can MD cord-104317-t30dg6oj 10 15 be be VB cord-104317-t30dg6oj 10 16 classified classify VBN cord-104317-t30dg6oj 10 17 based base VBN cord-104317-t30dg6oj 10 18 on on IN cord-104317-t30dg6oj 10 19 principles principle NNS cord-104317-t30dg6oj 10 20 of of IN cord-104317-t30dg6oj 10 21 ecology ecology NN cord-104317-t30dg6oj 10 22 . . . cord-104317-t30dg6oj 11 1 The the DT cord-104317-t30dg6oj 11 2 scaffold scaffold NN cord-104317-t30dg6oj 11 3 not not RB cord-104317-t30dg6oj 11 4 only only RB cord-104317-t30dg6oj 11 5 enables enable VBZ cord-104317-t30dg6oj 11 6 categorization categorization NN cord-104317-t30dg6oj 11 7 of of IN cord-104317-t30dg6oj 11 8 the the DT cord-104317-t30dg6oj 11 9 human human JJ cord-104317-t30dg6oj 11 10 virome virome NN cord-104317-t30dg6oj 11 11 , , , cord-104317-t30dg6oj 11 12 but but CC cord-104317-t30dg6oj 11 13 can can MD cord-104317-t30dg6oj 11 14 also also RB cord-104317-t30dg6oj 11 15 inform inform VB cord-104317-t30dg6oj 11 16 research research NN cord-104317-t30dg6oj 11 17 aimed aim VBN cord-104317-t30dg6oj 11 18 at at IN cord-104317-t30dg6oj 11 19 identifying identify VBG cord-104317-t30dg6oj 11 20 novel novel JJ cord-104317-t30dg6oj 11 21 virus virus NN cord-104317-t30dg6oj 11 22 - - HYPH cord-104317-t30dg6oj 11 23 host host NN cord-104317-t30dg6oj 11 24 interactions interaction NNS cord-104317-t30dg6oj 11 25 . . . cord-104317-t30dg6oj 12 1 The the DT cord-104317-t30dg6oj 12 2 term term NN cord-104317-t30dg6oj 12 3 " " `` cord-104317-t30dg6oj 12 4 microbiome microbiome NN cord-104317-t30dg6oj 12 5 " " '' cord-104317-t30dg6oj 12 6 was be VBD cord-104317-t30dg6oj 12 7 coined coin VBN cord-104317-t30dg6oj 12 8 by by IN cord-104317-t30dg6oj 12 9 Whipps Whipps NNP cord-104317-t30dg6oj 12 10 , , , cord-104317-t30dg6oj 12 11 Lewis Lewis NNP cord-104317-t30dg6oj 12 12 , , , cord-104317-t30dg6oj 12 13 and and CC cord-104317-t30dg6oj 12 14 Cooke Cooke NNP cord-104317-t30dg6oj 12 15 in in IN cord-104317-t30dg6oj 12 16 1988 1988 CD cord-104317-t30dg6oj 12 17 , , , cord-104317-t30dg6oj 12 18 defined define VBN cord-104317-t30dg6oj 12 19 as as IN cord-104317-t30dg6oj 12 20 " " `` cord-104317-t30dg6oj 12 21 a a DT cord-104317-t30dg6oj 12 22 characteristic characteristic JJ cord-104317-t30dg6oj 12 23 microbial microbial JJ cord-104317-t30dg6oj 12 24 community community NN cord-104317-t30dg6oj 12 25 occupying occupy VBG cord-104317-t30dg6oj 12 26 a a DT cord-104317-t30dg6oj 12 27 reasonably reasonably RB cord-104317-t30dg6oj 12 28 well well RB cord-104317-t30dg6oj 12 29 defined define VBN cord-104317-t30dg6oj 12 30 habitat habitat NN cord-104317-t30dg6oj 12 31 which which WDT cord-104317-t30dg6oj 12 32 has have VBZ cord-104317-t30dg6oj 12 33 distinct distinct JJ cord-104317-t30dg6oj 12 34 physico physico NN cord-104317-t30dg6oj 12 35 - - HYPH cord-104317-t30dg6oj 12 36 chemical chemical NN cord-104317-t30dg6oj 12 37 properties property NNS cord-104317-t30dg6oj 12 38 " " '' cord-104317-t30dg6oj 12 39 [ [ -LRB- cord-104317-t30dg6oj 12 40 1 1 CD cord-104317-t30dg6oj 12 41 ] ] -RRB- cord-104317-t30dg6oj 12 42 . . . cord-104317-t30dg6oj 13 1 Many many JJ cord-104317-t30dg6oj 13 2 attribute attribute VBP cord-104317-t30dg6oj 13 3 the the DT cord-104317-t30dg6oj 13 4 popularization popularization NN cord-104317-t30dg6oj 13 5 of of IN cord-104317-t30dg6oj 13 6 the the DT cord-104317-t30dg6oj 13 7 term term NN cord-104317-t30dg6oj 13 8 to to IN cord-104317-t30dg6oj 13 9 Nobel Nobel NNP cord-104317-t30dg6oj 13 10 laureate laureate NN cord-104317-t30dg6oj 13 11 Joshua Joshua NNP cord-104317-t30dg6oj 13 12 Lederberg Lederberg NNP cord-104317-t30dg6oj 13 13 , , , cord-104317-t30dg6oj 13 14 where where WRB cord-104317-t30dg6oj 13 15 he -PRON- PRP cord-104317-t30dg6oj 13 16 ( ( -LRB- cord-104317-t30dg6oj 13 17 anthropocentrically anthropocentrically RB cord-104317-t30dg6oj 13 18 ) ) -RRB- cord-104317-t30dg6oj 13 19 defined define VBD cord-104317-t30dg6oj 13 20 the the DT cord-104317-t30dg6oj 13 21 microbiome microbiome NN cord-104317-t30dg6oj 13 22 as as IN cord-104317-t30dg6oj 13 23 " " `` cord-104317-t30dg6oj 13 24 the the DT cord-104317-t30dg6oj 13 25 ecological ecological JJ cord-104317-t30dg6oj 13 26 community community NN cord-104317-t30dg6oj 13 27 of of IN cord-104317-t30dg6oj 13 28 commensal commensal JJ cord-104317-t30dg6oj 13 29 , , , cord-104317-t30dg6oj 13 30 symbiotic symbiotic JJ cord-104317-t30dg6oj 13 31 , , , cord-104317-t30dg6oj 13 32 and and CC cord-104317-t30dg6oj 13 33 pathogenic pathogenic JJ cord-104317-t30dg6oj 13 34 microorganisms microorganism NNS cord-104317-t30dg6oj 13 35 that that WDT cord-104317-t30dg6oj 13 36 literally literally RB cord-104317-t30dg6oj 13 37 share share VBP cord-104317-t30dg6oj 13 38 our -PRON- PRP$ cord-104317-t30dg6oj 13 39 body body NN cord-104317-t30dg6oj 13 40 space space NN cord-104317-t30dg6oj 13 41 and and CC cord-104317-t30dg6oj 13 42 have have VBP cord-104317-t30dg6oj 13 43 been be VBN cord-104317-t30dg6oj 13 44 all all RB cord-104317-t30dg6oj 13 45 but but CC cord-104317-t30dg6oj 13 46 ignored ignore VBN cord-104317-t30dg6oj 13 47 as as IN cord-104317-t30dg6oj 13 48 determinants determinant NNS cord-104317-t30dg6oj 13 49 of of IN cord-104317-t30dg6oj 13 50 health health NN cord-104317-t30dg6oj 13 51 and and CC cord-104317-t30dg6oj 13 52 disease disease NN cord-104317-t30dg6oj 13 53 " " '' cord-104317-t30dg6oj 13 54 [ [ -LRB- cord-104317-t30dg6oj 13 55 2 2 CD cord-104317-t30dg6oj 13 56 ] ] -RRB- cord-104317-t30dg6oj 13 57 . . . cord-104317-t30dg6oj 14 1 The the DT cord-104317-t30dg6oj 14 2 community community NN cord-104317-t30dg6oj 14 3 of of IN cord-104317-t30dg6oj 14 4 microorganisms microorganism NNS cord-104317-t30dg6oj 14 5 referenced reference VBN cord-104317-t30dg6oj 14 6 in in IN cord-104317-t30dg6oj 14 7 these these DT cord-104317-t30dg6oj 14 8 definitions definition NNS cord-104317-t30dg6oj 14 9 includes include VBZ cord-104317-t30dg6oj 14 10 viruses virus NNS cord-104317-t30dg6oj 14 11 , , , cord-104317-t30dg6oj 14 12 bacteria bacteria NNS cord-104317-t30dg6oj 14 13 , , , cord-104317-t30dg6oj 14 14 fungi fungus NNS cord-104317-t30dg6oj 14 15 , , , cord-104317-t30dg6oj 14 16 protozoa protozoan NNS cord-104317-t30dg6oj 14 17 , , , cord-104317-t30dg6oj 14 18 and and CC cord-104317-t30dg6oj 14 19 archaea archaea NNS cord-104317-t30dg6oj 14 20 . . . cord-104317-t30dg6oj 15 1 Within within IN cord-104317-t30dg6oj 15 2 this this DT cord-104317-t30dg6oj 15 3 community community NN cord-104317-t30dg6oj 15 4 there there EX cord-104317-t30dg6oj 15 5 is be VBZ cord-104317-t30dg6oj 15 6 an an DT cord-104317-t30dg6oj 15 7 inherent inherent JJ cord-104317-t30dg6oj 15 8 plasticity plasticity NN cord-104317-t30dg6oj 15 9 arising arise VBG cord-104317-t30dg6oj 15 10 from from IN cord-104317-t30dg6oj 15 11 the the DT cord-104317-t30dg6oj 15 12 interaction interaction NN cord-104317-t30dg6oj 15 13 of of IN cord-104317-t30dg6oj 15 14 organisms organism NNS cord-104317-t30dg6oj 15 15 with with IN cord-104317-t30dg6oj 15 16 one one CD cord-104317-t30dg6oj 15 17 another another DT cord-104317-t30dg6oj 15 18 and and CC cord-104317-t30dg6oj 15 19 with with IN cord-104317-t30dg6oj 15 20 their -PRON- PRP$ cord-104317-t30dg6oj 15 21 environment environment NN cord-104317-t30dg6oj 15 22 . . . cord-104317-t30dg6oj 16 1 Such such JJ cord-104317-t30dg6oj 16 2 meta meta JJ cord-104317-t30dg6oj 16 3 - - HYPH cord-104317-t30dg6oj 16 4 interactions interaction NNS cord-104317-t30dg6oj 16 5 lead lead VBP cord-104317-t30dg6oj 16 6 to to IN cord-104317-t30dg6oj 16 7 complex complex JJ cord-104317-t30dg6oj 16 8 repercussions repercussion NNS cord-104317-t30dg6oj 16 9 for for IN cord-104317-t30dg6oj 16 10 each each DT cord-104317-t30dg6oj 16 11 level level NN cord-104317-t30dg6oj 16 12 of of IN cord-104317-t30dg6oj 16 13 life life NN cord-104317-t30dg6oj 16 14 , , , cord-104317-t30dg6oj 16 15 and and CC cord-104317-t30dg6oj 16 16 this this DT cord-104317-t30dg6oj 16 17 review review NN cord-104317-t30dg6oj 16 18 will will MD cord-104317-t30dg6oj 16 19 focus focus VB cord-104317-t30dg6oj 16 20 on on IN cord-104317-t30dg6oj 16 21 the the DT cord-104317-t30dg6oj 16 22 consequences consequence NNS cord-104317-t30dg6oj 16 23 that that WDT cord-104317-t30dg6oj 16 24 have have VBP cord-104317-t30dg6oj 16 25 implications implication NNS cord-104317-t30dg6oj 16 26 for for IN cord-104317-t30dg6oj 16 27 human human JJ cord-104317-t30dg6oj 16 28 health health NN cord-104317-t30dg6oj 16 29 . . . cord-104317-t30dg6oj 17 1 The the DT cord-104317-t30dg6oj 17 2 viral viral JJ cord-104317-t30dg6oj 17 3 component component NN cord-104317-t30dg6oj 17 4 of of IN cord-104317-t30dg6oj 17 5 the the DT cord-104317-t30dg6oj 17 6 microbiome microbiome NN cord-104317-t30dg6oj 17 7 , , , cord-104317-t30dg6oj 17 8 termed term VBD cord-104317-t30dg6oj 17 9 the the DT cord-104317-t30dg6oj 17 10 " " `` cord-104317-t30dg6oj 17 11 virome virome JJ cord-104317-t30dg6oj 17 12 " " '' cord-104317-t30dg6oj 17 13 [ [ -LRB- cord-104317-t30dg6oj 17 14 3 3 CD cord-104317-t30dg6oj 17 15 ] ] -RRB- cord-104317-t30dg6oj 17 16 is be VBZ cord-104317-t30dg6oj 17 17 a a DT cord-104317-t30dg6oj 17 18 poorly poorly RB cord-104317-t30dg6oj 17 19 understood understand VBN cord-104317-t30dg6oj 17 20 facet facet NN cord-104317-t30dg6oj 17 21 of of IN cord-104317-t30dg6oj 17 22 the the DT cord-104317-t30dg6oj 17 23 microbiome microbiome NN cord-104317-t30dg6oj 17 24 , , , cord-104317-t30dg6oj 17 25 despite despite IN cord-104317-t30dg6oj 17 26 having have VBG cord-104317-t30dg6oj 17 27 the the DT cord-104317-t30dg6oj 17 28 potential potential NN cord-104317-t30dg6oj 17 29 to to TO cord-104317-t30dg6oj 17 30 significantly significantly RB cord-104317-t30dg6oj 17 31 impact impact VB cord-104317-t30dg6oj 17 32 human human JJ cord-104317-t30dg6oj 17 33 health health NN cord-104317-t30dg6oj 17 34 . . . cord-104317-t30dg6oj 18 1 From from IN cord-104317-t30dg6oj 18 2 a a DT cord-104317-t30dg6oj 18 3 philosophical philosophical JJ cord-104317-t30dg6oj 18 4 perspective perspective NN cord-104317-t30dg6oj 18 5 , , , cord-104317-t30dg6oj 18 6 viruses virus NNS cord-104317-t30dg6oj 18 7 were be VBD cord-104317-t30dg6oj 18 8 likely likely RB cord-104317-t30dg6oj 18 9 integral integral JJ cord-104317-t30dg6oj 18 10 to to IN cord-104317-t30dg6oj 18 11 the the DT cord-104317-t30dg6oj 18 12 very very JJ cord-104317-t30dg6oj 18 13 existence existence NN cord-104317-t30dg6oj 18 14 of of IN cord-104317-t30dg6oj 18 15 man man NN cord-104317-t30dg6oj 18 16 as as IN cord-104317-t30dg6oj 18 17 the the DT cord-104317-t30dg6oj 18 18 primordial primordial JJ cord-104317-t30dg6oj 18 19 precursor precursor NN cord-104317-t30dg6oj 18 20 to to IN cord-104317-t30dg6oj 18 21 all all DT cord-104317-t30dg6oj 18 22 current current JJ cord-104317-t30dg6oj 18 23 life life NN cord-104317-t30dg6oj 18 24 on on IN cord-104317-t30dg6oj 18 25 earth earth NN cord-104317-t30dg6oj 18 26 [ [ -LRB- cord-104317-t30dg6oj 18 27 4 4 CD cord-104317-t30dg6oj 18 28 ] ] -RRB- cord-104317-t30dg6oj 18 29 . . . cord-104317-t30dg6oj 19 1 More more RBR cord-104317-t30dg6oj 19 2 tangibly tangibly RB cord-104317-t30dg6oj 19 3 , , , cord-104317-t30dg6oj 19 4 during during IN cord-104317-t30dg6oj 19 5 the the DT cord-104317-t30dg6oj 19 6 course course NN cord-104317-t30dg6oj 19 7 of of IN cord-104317-t30dg6oj 19 8 human human JJ cord-104317-t30dg6oj 19 9 evolution evolution NN cord-104317-t30dg6oj 19 10 , , , cord-104317-t30dg6oj 19 11 the the DT cord-104317-t30dg6oj 19 12 viruses virus NNS cord-104317-t30dg6oj 19 13 in in IN cord-104317-t30dg6oj 19 14 and and CC cord-104317-t30dg6oj 19 15 around around IN cord-104317-t30dg6oj 19 16 humans human NNS cord-104317-t30dg6oj 19 17 not not RB cord-104317-t30dg6oj 19 18 only only RB cord-104317-t30dg6oj 19 19 drove drive VBD cord-104317-t30dg6oj 19 20 evolution evolution NN cord-104317-t30dg6oj 19 21 via via IN cord-104317-t30dg6oj 19 22 selective selective JJ cord-104317-t30dg6oj 19 23 pressure pressure NN cord-104317-t30dg6oj 19 24 , , , cord-104317-t30dg6oj 19 25 but but CC cord-104317-t30dg6oj 19 26 also also RB cord-104317-t30dg6oj 19 27 contributed contribute VBD cord-104317-t30dg6oj 19 28 novel novel JJ cord-104317-t30dg6oj 19 29 genetic genetic JJ cord-104317-t30dg6oj 19 30 material material NN cord-104317-t30dg6oj 19 31 . . . cord-104317-t30dg6oj 20 1 In in IN cord-104317-t30dg6oj 20 2 fact fact NN cord-104317-t30dg6oj 20 3 , , , cord-104317-t30dg6oj 20 4 approximately approximately RB cord-104317-t30dg6oj 20 5 42 42 CD cord-104317-t30dg6oj 20 6 percent percent NN cord-104317-t30dg6oj 20 7 of of IN cord-104317-t30dg6oj 20 8 the the DT cord-104317-t30dg6oj 20 9 human human JJ cord-104317-t30dg6oj 20 10 genome genome NN cord-104317-t30dg6oj 20 11 is be VBZ cord-104317-t30dg6oj 20 12 composed compose VBN cord-104317-t30dg6oj 20 13 of of IN cord-104317-t30dg6oj 20 14 viral viral JJ cord-104317-t30dg6oj 20 15 sequence sequence NN cord-104317-t30dg6oj 20 16 [ [ -LRB- cord-104317-t30dg6oj 20 17 5 5 CD cord-104317-t30dg6oj 20 18 ] ] -RRB- cord-104317-t30dg6oj 20 19 . . . cord-104317-t30dg6oj 21 1 This this DT cord-104317-t30dg6oj 21 2 role role NN cord-104317-t30dg6oj 21 3 as as IN cord-104317-t30dg6oj 21 4 a a DT cord-104317-t30dg6oj 21 5 major major JJ cord-104317-t30dg6oj 21 6 agent agent NN cord-104317-t30dg6oj 21 7 driving drive VBG cord-104317-t30dg6oj 21 8 horizontal horizontal JJ cord-104317-t30dg6oj 21 9 ( ( -LRB- cord-104317-t30dg6oj 21 10 i.e. i.e. FW cord-104317-t30dg6oj 21 11 , , , cord-104317-t30dg6oj 21 12 non non JJ cord-104317-t30dg6oj 21 13 - - JJ cord-104317-t30dg6oj 21 14 reproductive reproductive JJ cord-104317-t30dg6oj 21 15 ) ) -RRB- cord-104317-t30dg6oj 21 16 gene gene NN cord-104317-t30dg6oj 21 17 transfer transfer NN cord-104317-t30dg6oj 21 18 between between IN cord-104317-t30dg6oj 21 19 biomes biome NNS cord-104317-t30dg6oj 21 20 [ [ -LRB- cord-104317-t30dg6oj 21 21 6 6 CD cord-104317-t30dg6oj 21 22 ] ] -RRB- cord-104317-t30dg6oj 21 23 [ [ -LRB- cord-104317-t30dg6oj 21 24 7 7 CD cord-104317-t30dg6oj 21 25 ] ] -RRB- cord-104317-t30dg6oj 21 26 [ [ -LRB- cord-104317-t30dg6oj 21 27 8 8 CD cord-104317-t30dg6oj 21 28 ] ] -RRB- cord-104317-t30dg6oj 21 29 [ [ -LRB- cord-104317-t30dg6oj 21 30 9 9 CD cord-104317-t30dg6oj 21 31 ] ] -RRB- cord-104317-t30dg6oj 21 32 and and CC cord-104317-t30dg6oj 21 33 the the DT cord-104317-t30dg6oj 21 34 fact fact NN cord-104317-t30dg6oj 21 35 that that IN cord-104317-t30dg6oj 21 36 the the DT cord-104317-t30dg6oj 21 37 diversity diversity NN cord-104317-t30dg6oj 21 38 , , , cord-104317-t30dg6oj 21 39 complexity complexity NN cord-104317-t30dg6oj 21 40 , , , cord-104317-t30dg6oj 21 41 and and CC cord-104317-t30dg6oj 21 42 abundance abundance NN cord-104317-t30dg6oj 21 43 of of IN cord-104317-t30dg6oj 21 44 viruses virus NNS cord-104317-t30dg6oj 21 45 surpasses surpass VBZ cord-104317-t30dg6oj 21 46 any any DT cord-104317-t30dg6oj 21 47 other other JJ cord-104317-t30dg6oj 21 48 biological biological JJ cord-104317-t30dg6oj 21 49 entity entity NN cord-104317-t30dg6oj 21 50 make make VBP cord-104317-t30dg6oj 21 51 it -PRON- PRP cord-104317-t30dg6oj 21 52 apparent apparent JJ cord-104317-t30dg6oj 21 53 that that IN cord-104317-t30dg6oj 21 54 understanding understanding NN cord-104317-t30dg6oj 21 55 viromes virome NNS cord-104317-t30dg6oj 21 56 will will MD cord-104317-t30dg6oj 21 57 impart impart VB cord-104317-t30dg6oj 21 58 unparalleled unparalleled JJ cord-104317-t30dg6oj 21 59 understanding understanding NN cord-104317-t30dg6oj 21 60 of of IN cord-104317-t30dg6oj 21 61 the the DT cord-104317-t30dg6oj 21 62 organisms organism NNS cord-104317-t30dg6oj 21 63 they -PRON- PRP cord-104317-t30dg6oj 21 64 inhabit inhabit VBP cord-104317-t30dg6oj 21 65 [ [ -LRB- cord-104317-t30dg6oj 21 66 10 10 CD cord-104317-t30dg6oj 21 67 ] ] -RRB- cord-104317-t30dg6oj 21 68 . . . cord-104317-t30dg6oj 22 1 However however RB cord-104317-t30dg6oj 22 2 , , , cord-104317-t30dg6oj 22 3 the the DT cord-104317-t30dg6oj 22 4 obvious obvious JJ cord-104317-t30dg6oj 22 5 importance importance NN cord-104317-t30dg6oj 22 6 of of IN cord-104317-t30dg6oj 22 7 viruses virus NNS cord-104317-t30dg6oj 22 8 in in IN cord-104317-t30dg6oj 22 9 the the DT cord-104317-t30dg6oj 22 10 composition composition NN cord-104317-t30dg6oj 22 11 of of IN cord-104317-t30dg6oj 22 12 all all DT cord-104317-t30dg6oj 22 13 biomes biome NNS cord-104317-t30dg6oj 22 14 has have VBZ cord-104317-t30dg6oj 22 15 not not RB cord-104317-t30dg6oj 22 16 ( ( -LRB- cord-104317-t30dg6oj 22 17 yet yet RB cord-104317-t30dg6oj 22 18 ) ) -RRB- cord-104317-t30dg6oj 22 19 been be VBN cord-104317-t30dg6oj 22 20 met meet VBN cord-104317-t30dg6oj 22 21 with with IN cord-104317-t30dg6oj 22 22 an an DT cord-104317-t30dg6oj 22 23 appropriate appropriate JJ cord-104317-t30dg6oj 22 24 fervor fervor NN cord-104317-t30dg6oj 22 25 for for IN cord-104317-t30dg6oj 22 26 the the DT cord-104317-t30dg6oj 22 27 characterization characterization NN cord-104317-t30dg6oj 22 28 of of IN cord-104317-t30dg6oj 22 29 the the DT cord-104317-t30dg6oj 22 30 viral viral JJ cord-104317-t30dg6oj 22 31 REVIEW review NN cord-104317-t30dg6oj 23 1 Recent recent JJ cord-104317-t30dg6oj 23 2 advances advance NNS cord-104317-t30dg6oj 23 3 in in IN cord-104317-t30dg6oj 23 4 sequencing sequencing NN cord-104317-t30dg6oj 23 5 technologies technology NNS cord-104317-t30dg6oj 23 6 have have VBP cord-104317-t30dg6oj 23 7 opened open VBN cord-104317-t30dg6oj 23 8 the the DT cord-104317-t30dg6oj 23 9 door door NN cord-104317-t30dg6oj 23 10 for for IN cord-104317-t30dg6oj 23 11 the the DT cord-104317-t30dg6oj 23 12 classification classification NN cord-104317-t30dg6oj 23 13 of of IN cord-104317-t30dg6oj 23 14 the the DT cord-104317-t30dg6oj 23 15 human human JJ cord-104317-t30dg6oj 23 16 virome virome NN cord-104317-t30dg6oj 23 17 . . . cord-104317-t30dg6oj 24 1 While while IN cord-104317-t30dg6oj 24 2 taxonomic taxonomic JJ cord-104317-t30dg6oj 24 3 classification classification NN cord-104317-t30dg6oj 24 4 can can MD cord-104317-t30dg6oj 24 5 be be VB cord-104317-t30dg6oj 24 6 applied apply VBN cord-104317-t30dg6oj 24 7 to to IN cord-104317-t30dg6oj 24 8 the the DT cord-104317-t30dg6oj 24 9 viruses virus NNS cord-104317-t30dg6oj 24 10 identified identify VBN cord-104317-t30dg6oj 24 11 in in IN cord-104317-t30dg6oj 24 12 such such JJ cord-104317-t30dg6oj 24 13 studies study NNS cord-104317-t30dg6oj 24 14 , , , cord-104317-t30dg6oj 24 15 this this DT cord-104317-t30dg6oj 24 16 gives give VBZ cord-104317-t30dg6oj 24 17 no no DT cord-104317-t30dg6oj 24 18 information information NN cord-104317-t30dg6oj 24 19 as as IN cord-104317-t30dg6oj 24 20 to to IN cord-104317-t30dg6oj 24 21 the the DT cord-104317-t30dg6oj 24 22 type type NN cord-104317-t30dg6oj 24 23 of of IN cord-104317-t30dg6oj 24 24 interaction interaction NN cord-104317-t30dg6oj 24 25 the the DT cord-104317-t30dg6oj 24 26 virus virus NN cord-104317-t30dg6oj 24 27 has have VBZ cord-104317-t30dg6oj 24 28 with with IN cord-104317-t30dg6oj 24 29 the the DT cord-104317-t30dg6oj 24 30 host host NN cord-104317-t30dg6oj 24 31 . . . cord-104317-t30dg6oj 25 1 As as IN cord-104317-t30dg6oj 25 2 follow follow VB cord-104317-t30dg6oj 25 3 - - HYPH cord-104317-t30dg6oj 25 4 up up RP cord-104317-t30dg6oj 25 5 studies study NNS cord-104317-t30dg6oj 25 6 are be VBP cord-104317-t30dg6oj 25 7 performed perform VBN cord-104317-t30dg6oj 25 8 to to TO cord-104317-t30dg6oj 25 9 address address VB cord-104317-t30dg6oj 25 10 these these DT cord-104317-t30dg6oj 25 11 questions question NNS cord-104317-t30dg6oj 25 12 , , , cord-104317-t30dg6oj 25 13 the the DT cord-104317-t30dg6oj 25 14 description description NN cord-104317-t30dg6oj 25 15 of of IN cord-104317-t30dg6oj 25 16 these these DT cord-104317-t30dg6oj 25 17 virus virus NN cord-104317-t30dg6oj 25 18 - - HYPH cord-104317-t30dg6oj 25 19 host host NN cord-104317-t30dg6oj 25 20 interactions interaction NNS cord-104317-t30dg6oj 25 21 would would MD cord-104317-t30dg6oj 25 22 be be VB cord-104317-t30dg6oj 25 23 greatly greatly RB cord-104317-t30dg6oj 25 24 enriched enrich VBN cord-104317-t30dg6oj 25 25 by by IN cord-104317-t30dg6oj 25 26 applying apply VBG cord-104317-t30dg6oj 25 27 a a DT cord-104317-t30dg6oj 25 28 standard standard JJ cord-104317-t30dg6oj 25 29 set set NN cord-104317-t30dg6oj 25 30 of of IN cord-104317-t30dg6oj 25 31 definitions definition NNS cord-104317-t30dg6oj 25 32 that that WDT cord-104317-t30dg6oj 25 33 typify typify VBP cord-104317-t30dg6oj 25 34 them -PRON- PRP cord-104317-t30dg6oj 25 35 . . . cord-104317-t30dg6oj 26 1 This this DT cord-104317-t30dg6oj 26 2 paper paper NN cord-104317-t30dg6oj 26 3 describes describe VBZ cord-104317-t30dg6oj 26 4 a a DT cord-104317-t30dg6oj 26 5 framework framework NN cord-104317-t30dg6oj 26 6 with with IN cord-104317-t30dg6oj 26 7 which which WDT cord-104317-t30dg6oj 26 8 all all DT cord-104317-t30dg6oj 26 9 members member NNS cord-104317-t30dg6oj 26 10 of of IN cord-104317-t30dg6oj 26 11 the the DT cord-104317-t30dg6oj 26 12 human human JJ cord-104317-t30dg6oj 26 13 virome virome NN cord-104317-t30dg6oj 26 14 can can MD cord-104317-t30dg6oj 26 15 be be VB cord-104317-t30dg6oj 26 16 classified classify VBN cord-104317-t30dg6oj 26 17 based base VBN cord-104317-t30dg6oj 26 18 on on IN cord-104317-t30dg6oj 26 19 principles principle NNS cord-104317-t30dg6oj 26 20 of of IN cord-104317-t30dg6oj 26 21 ecology ecology NN cord-104317-t30dg6oj 26 22 . . . cord-104317-t30dg6oj 27 1 The the DT cord-104317-t30dg6oj 27 2 scaffold scaffold NN cord-104317-t30dg6oj 27 3 not not RB cord-104317-t30dg6oj 27 4 only only RB cord-104317-t30dg6oj 27 5 enables enable VBZ cord-104317-t30dg6oj 27 6 categorization categorization NN cord-104317-t30dg6oj 27 7 of of IN cord-104317-t30dg6oj 27 8 the the DT cord-104317-t30dg6oj 27 9 human human JJ cord-104317-t30dg6oj 27 10 virome virome NN cord-104317-t30dg6oj 27 11 , , , cord-104317-t30dg6oj 27 12 but but CC cord-104317-t30dg6oj 27 13 can can MD cord-104317-t30dg6oj 27 14 also also RB cord-104317-t30dg6oj 27 15 inform inform VB cord-104317-t30dg6oj 27 16 research research NN cord-104317-t30dg6oj 27 17 aimed aim VBN cord-104317-t30dg6oj 27 18 at at IN cord-104317-t30dg6oj 27 19 identifying identify VBG cord-104317-t30dg6oj 27 20 novel novel JJ cord-104317-t30dg6oj 27 21 virus virus NN cord-104317-t30dg6oj 27 22 - - HYPH cord-104317-t30dg6oj 27 23 host host NN cord-104317-t30dg6oj 27 24 interactions interaction NNS cord-104317-t30dg6oj 27 25 . . . cord-104317-t30dg6oj 28 1 component component NN cord-104317-t30dg6oj 28 2 of of IN cord-104317-t30dg6oj 28 3 microbiomes microbiome NNS cord-104317-t30dg6oj 28 4 . . . cord-104317-t30dg6oj 29 1 The the DT cord-104317-t30dg6oj 29 2 original original JJ cord-104317-t30dg6oj 29 3 explosion explosion NN cord-104317-t30dg6oj 29 4 of of IN cord-104317-t30dg6oj 29 5 microbiome microbiome NN cord-104317-t30dg6oj 29 6 information information NN cord-104317-t30dg6oj 29 7 was be VBD cord-104317-t30dg6oj 29 8 spurred spur VBN cord-104317-t30dg6oj 29 9 by by IN cord-104317-t30dg6oj 29 10 the the DT cord-104317-t30dg6oj 29 11 utilization utilization NN cord-104317-t30dg6oj 29 12 of of IN cord-104317-t30dg6oj 29 13 16S 16s JJ cord-104317-t30dg6oj 29 14 sequencing sequencing NN cord-104317-t30dg6oj 29 15 technology technology NN cord-104317-t30dg6oj 29 16 , , , cord-104317-t30dg6oj 29 17 which which WDT cord-104317-t30dg6oj 29 18 can can MD cord-104317-t30dg6oj 29 19 give give VB cord-104317-t30dg6oj 29 20 vast vast JJ cord-104317-t30dg6oj 29 21 information information NN cord-104317-t30dg6oj 29 22 about about IN cord-104317-t30dg6oj 29 23 microbial microbial JJ cord-104317-t30dg6oj 29 24 communities community NNS cord-104317-t30dg6oj 29 25 using use VBG cord-104317-t30dg6oj 29 26 universal universal JJ cord-104317-t30dg6oj 29 27 primers primer NNS cord-104317-t30dg6oj 29 28 [ [ -LRB- cord-104317-t30dg6oj 29 29 11 11 CD cord-104317-t30dg6oj 29 30 ] ] -RRB- cord-104317-t30dg6oj 29 31 . . . cord-104317-t30dg6oj 30 1 However however RB cord-104317-t30dg6oj 30 2 , , , cord-104317-t30dg6oj 30 3 this this DT cord-104317-t30dg6oj 30 4 technique technique NN cord-104317-t30dg6oj 30 5 is be VBZ cord-104317-t30dg6oj 30 6 specific specific JJ cord-104317-t30dg6oj 30 7 to to IN cord-104317-t30dg6oj 30 8 organisms organism NNS cord-104317-t30dg6oj 30 9 with with IN cord-104317-t30dg6oj 30 10 ribosomes ribosome NNS cord-104317-t30dg6oj 30 11 , , , cord-104317-t30dg6oj 30 12 so so RB cord-104317-t30dg6oj 30 13 early early JJ cord-104317-t30dg6oj 30 14 research research NN cord-104317-t30dg6oj 30 15 focused focus VBD cord-104317-t30dg6oj 30 16 on on IN cord-104317-t30dg6oj 30 17 analysis analysis NN cord-104317-t30dg6oj 30 18 of of IN cord-104317-t30dg6oj 30 19 bacterial bacterial JJ cord-104317-t30dg6oj 30 20 sequences sequence NNS cord-104317-t30dg6oj 30 21 rather rather RB cord-104317-t30dg6oj 30 22 than than IN cord-104317-t30dg6oj 30 23 much much RB cord-104317-t30dg6oj 30 24 more more RBR cord-104317-t30dg6oj 30 25 technically technically RB cord-104317-t30dg6oj 30 26 challenging challenging JJ cord-104317-t30dg6oj 30 27 viral viral JJ cord-104317-t30dg6oj 30 28 sequences sequence NNS cord-104317-t30dg6oj 30 29 [ [ -LRB- cord-104317-t30dg6oj 30 30 12 12 CD cord-104317-t30dg6oj 30 31 ] ] -RRB- cord-104317-t30dg6oj 30 32 . . . cord-104317-t30dg6oj 31 1 Thankfully thankfully RB cord-104317-t30dg6oj 31 2 , , , cord-104317-t30dg6oj 31 3 recent recent JJ cord-104317-t30dg6oj 31 4 advances advance NNS cord-104317-t30dg6oj 31 5 in in IN cord-104317-t30dg6oj 31 6 next next JJ cord-104317-t30dg6oj 31 7 generation generation NN cord-104317-t30dg6oj 31 8 sequencing sequencing NN cord-104317-t30dg6oj 31 9 technologies technology NNS cord-104317-t30dg6oj 31 10 are be VBP cord-104317-t30dg6oj 31 11 making make VBG cord-104317-t30dg6oj 31 12 virome virome NN cord-104317-t30dg6oj 31 13 characterization characterization NN cord-104317-t30dg6oj 31 14 more more RBR cord-104317-t30dg6oj 31 15 technologically technologically RB cord-104317-t30dg6oj 31 16 and and CC cord-104317-t30dg6oj 31 17 financially financially RB cord-104317-t30dg6oj 31 18 possible possible JJ cord-104317-t30dg6oj 31 19 and and CC cord-104317-t30dg6oj 31 20 will will MD cord-104317-t30dg6oj 31 21 ensure ensure VB cord-104317-t30dg6oj 31 22 an an DT cord-104317-t30dg6oj 31 23 explosion explosion NN cord-104317-t30dg6oj 31 24 of of IN cord-104317-t30dg6oj 31 25 virome virome JJ cord-104317-t30dg6oj 31 26 description description NN cord-104317-t30dg6oj 31 27 in in IN cord-104317-t30dg6oj 31 28 the the DT cord-104317-t30dg6oj 31 29 near near JJ cord-104317-t30dg6oj 31 30 future future NN cord-104317-t30dg6oj 31 31 [ [ -LRB- cord-104317-t30dg6oj 31 32 13 13 CD cord-104317-t30dg6oj 31 33 , , , cord-104317-t30dg6oj 31 34 14 14 CD cord-104317-t30dg6oj 31 35 ] ] -RRB- cord-104317-t30dg6oj 31 36 . . . cord-104317-t30dg6oj 32 1 In in IN cord-104317-t30dg6oj 32 2 an an DT cord-104317-t30dg6oj 32 3 effort effort NN cord-104317-t30dg6oj 32 4 to to TO cord-104317-t30dg6oj 32 5 facilitate facilitate VB cord-104317-t30dg6oj 32 6 such such JJ cord-104317-t30dg6oj 32 7 classification classification NN cord-104317-t30dg6oj 32 8 of of IN cord-104317-t30dg6oj 32 9 the the DT cord-104317-t30dg6oj 32 10 human human JJ cord-104317-t30dg6oj 32 11 virome virome NNP cord-104317-t30dg6oj 32 12 , , , cord-104317-t30dg6oj 32 13 it -PRON- PRP cord-104317-t30dg6oj 32 14 is be VBZ cord-104317-t30dg6oj 32 15 prudent prudent JJ cord-104317-t30dg6oj 32 16 to to TO cord-104317-t30dg6oj 32 17 use use VB cord-104317-t30dg6oj 32 18 basic basic JJ cord-104317-t30dg6oj 32 19 ecological ecological JJ cord-104317-t30dg6oj 32 20 interactions interaction NNS cord-104317-t30dg6oj 32 21 both both DT cord-104317-t30dg6oj 32 22 to to TO cord-104317-t30dg6oj 32 23 organize organize VB cord-104317-t30dg6oj 32 24 current current JJ cord-104317-t30dg6oj 32 25 knowledge knowledge NN cord-104317-t30dg6oj 32 26 as as RB cord-104317-t30dg6oj 32 27 well well RB cord-104317-t30dg6oj 32 28 as as IN cord-104317-t30dg6oj 32 29 identify identify VB cord-104317-t30dg6oj 32 30 areas area NNS cord-104317-t30dg6oj 32 31 where where WRB cord-104317-t30dg6oj 32 32 new new JJ cord-104317-t30dg6oj 32 33 information information NN cord-104317-t30dg6oj 32 34 may may MD cord-104317-t30dg6oj 32 35 be be VB cord-104317-t30dg6oj 32 36 found find VBN cord-104317-t30dg6oj 32 37 . . . cord-104317-t30dg6oj 33 1 This this DT cord-104317-t30dg6oj 33 2 review review NN cord-104317-t30dg6oj 33 3 will will MD cord-104317-t30dg6oj 33 4 build build VB cord-104317-t30dg6oj 33 5 a a DT cord-104317-t30dg6oj 33 6 framework framework NN cord-104317-t30dg6oj 33 7 of of IN cord-104317-t30dg6oj 33 8 the the DT cord-104317-t30dg6oj 33 9 human human JJ cord-104317-t30dg6oj 33 10 virome virome NN cord-104317-t30dg6oj 33 11 from from IN cord-104317-t30dg6oj 33 12 an an DT cord-104317-t30dg6oj 33 13 ecological ecological JJ cord-104317-t30dg6oj 33 14 perspective perspective NN cord-104317-t30dg6oj 33 15 , , , cord-104317-t30dg6oj 33 16 identify identify VB cord-104317-t30dg6oj 33 17 currently currently RB cord-104317-t30dg6oj 33 18 underappreciated underappreciated JJ cord-104317-t30dg6oj 33 19 and and CC cord-104317-t30dg6oj 33 20 possibly possibly RB cord-104317-t30dg6oj 33 21 undiscovered undiscovered JJ cord-104317-t30dg6oj 33 22 roles role NNS cord-104317-t30dg6oj 33 23 of of IN cord-104317-t30dg6oj 33 24 the the DT cord-104317-t30dg6oj 33 25 virome virome NN cord-104317-t30dg6oj 33 26 , , , cord-104317-t30dg6oj 33 27 and and CC cord-104317-t30dg6oj 33 28 apply apply VB cord-104317-t30dg6oj 33 29 these these DT cord-104317-t30dg6oj 33 30 principles principle NNS cord-104317-t30dg6oj 33 31 to to IN cord-104317-t30dg6oj 33 32 analysis analysis NN cord-104317-t30dg6oj 33 33 of of IN cord-104317-t30dg6oj 33 34 the the DT cord-104317-t30dg6oj 33 35 role role NN cord-104317-t30dg6oj 33 36 of of IN cord-104317-t30dg6oj 33 37 the the DT cord-104317-t30dg6oj 33 38 virome virome NNP cord-104317-t30dg6oj 33 39 in in IN cord-104317-t30dg6oj 33 40 human human JJ cord-104317-t30dg6oj 33 41 health health NN cord-104317-t30dg6oj 33 42 . . . cord-104317-t30dg6oj 34 1 Such such PDT cord-104317-t30dg6oj 34 2 a a DT cord-104317-t30dg6oj 34 3 systematic systematic JJ cord-104317-t30dg6oj 34 4 conception conception NN cord-104317-t30dg6oj 34 5 of of IN cord-104317-t30dg6oj 34 6 the the DT cord-104317-t30dg6oj 34 7 structure structure NN cord-104317-t30dg6oj 34 8 of of IN cord-104317-t30dg6oj 34 9 these these DT cord-104317-t30dg6oj 34 10 ecological ecological JJ cord-104317-t30dg6oj 34 11 interactions interaction NNS cord-104317-t30dg6oj 34 12 can can MD cord-104317-t30dg6oj 34 13 also also RB cord-104317-t30dg6oj 34 14 facilitate facilitate VB cord-104317-t30dg6oj 34 15 the the DT cord-104317-t30dg6oj 34 16 application application NN cord-104317-t30dg6oj 34 17 of of IN cord-104317-t30dg6oj 34 18 similar similar JJ cord-104317-t30dg6oj 34 19 conventions convention NNS cord-104317-t30dg6oj 34 20 to to IN cord-104317-t30dg6oj 34 21 the the DT cord-104317-t30dg6oj 34 22 other other JJ cord-104317-t30dg6oj 34 23 components component NNS cord-104317-t30dg6oj 34 24 of of IN cord-104317-t30dg6oj 34 25 the the DT cord-104317-t30dg6oj 34 26 microbiome microbiome NN cord-104317-t30dg6oj 34 27 . . . cord-104317-t30dg6oj 35 1 While while IN cord-104317-t30dg6oj 35 2 appreciation appreciation NN cord-104317-t30dg6oj 35 3 of of IN cord-104317-t30dg6oj 35 4 the the DT cord-104317-t30dg6oj 35 5 possible possible JJ cord-104317-t30dg6oj 35 6 benefits benefit NNS cord-104317-t30dg6oj 35 7 of of IN cord-104317-t30dg6oj 35 8 the the DT cord-104317-t30dg6oj 35 9 human human JJ cord-104317-t30dg6oj 35 10 microbiome microbiome NN cord-104317-t30dg6oj 35 11 accumulated accumulate VBN cord-104317-t30dg6oj 35 12 in in IN cord-104317-t30dg6oj 35 13 the the DT cord-104317-t30dg6oj 35 14 latter latter JJ cord-104317-t30dg6oj 35 15 half half NN cord-104317-t30dg6oj 35 16 of of IN cord-104317-t30dg6oj 35 17 the the DT cord-104317-t30dg6oj 35 18 20th 20th JJ cord-104317-t30dg6oj 35 19 century century NN cord-104317-t30dg6oj 35 20 , , , cord-104317-t30dg6oj 35 21 a a DT cord-104317-t30dg6oj 35 22 concordant concordant JJ cord-104317-t30dg6oj 35 23 acknowledgement acknowledgement NN cord-104317-t30dg6oj 35 24 for for IN cord-104317-t30dg6oj 35 25 the the DT cord-104317-t30dg6oj 35 26 human human JJ cord-104317-t30dg6oj 35 27 virome virome NN cord-104317-t30dg6oj 35 28 was be VBD cord-104317-t30dg6oj 35 29 not not RB cord-104317-t30dg6oj 35 30 so so RB cord-104317-t30dg6oj 35 31 quickly quickly RB cord-104317-t30dg6oj 35 32 realized realize VBN cord-104317-t30dg6oj 35 33 [ [ -LRB- cord-104317-t30dg6oj 35 34 15 15 CD cord-104317-t30dg6oj 35 35 ] ] -RRB- cord-104317-t30dg6oj 35 36 . . . cord-104317-t30dg6oj 36 1 It -PRON- PRP cord-104317-t30dg6oj 36 2 is be VBZ cord-104317-t30dg6oj 36 3 likely likely JJ cord-104317-t30dg6oj 36 4 this this DT cord-104317-t30dg6oj 36 5 was be VBD cord-104317-t30dg6oj 36 6 because because IN cord-104317-t30dg6oj 36 7 human human JJ cord-104317-t30dg6oj 36 8 viruses virus NNS cord-104317-t30dg6oj 36 9 rely rely VBP cord-104317-t30dg6oj 36 10 on on IN cord-104317-t30dg6oj 36 11 invasion invasion NN cord-104317-t30dg6oj 36 12 of of IN cord-104317-t30dg6oj 36 13 host host NN cord-104317-t30dg6oj 36 14 cells cell NNS cord-104317-t30dg6oj 36 15 to to TO cord-104317-t30dg6oj 36 16 replicate replicate VB cord-104317-t30dg6oj 36 17 and and CC cord-104317-t30dg6oj 36 18 this this DT cord-104317-t30dg6oj 36 19 provokes provoke VBZ cord-104317-t30dg6oj 36 20 an an DT cord-104317-t30dg6oj 36 21 overwhelmingly overwhelmingly RB cord-104317-t30dg6oj 36 22 negative negative JJ cord-104317-t30dg6oj 36 23 impression impression NN cord-104317-t30dg6oj 36 24 . . . cord-104317-t30dg6oj 37 1 However however RB cord-104317-t30dg6oj 37 2 , , , cord-104317-t30dg6oj 37 3 all all DT cord-104317-t30dg6oj 37 4 interactions interaction NNS cord-104317-t30dg6oj 37 5 of of IN cord-104317-t30dg6oj 37 6 viruses virus NNS cord-104317-t30dg6oj 37 7 with with IN cord-104317-t30dg6oj 37 8 their -PRON- PRP$ cord-104317-t30dg6oj 37 9 hosts host NNS cord-104317-t30dg6oj 37 10 are be VBP cord-104317-t30dg6oj 37 11 symbioses symbiose NNS cord-104317-t30dg6oj 37 12 in in IN cord-104317-t30dg6oj 37 13 the the DT cord-104317-t30dg6oj 37 14 classical classical JJ cord-104317-t30dg6oj 37 15 sense sense NN cord-104317-t30dg6oj 37 16 [ [ -LRB- cord-104317-t30dg6oj 37 17 16 16 CD cord-104317-t30dg6oj 37 18 ] ] -RRB- cord-104317-t30dg6oj 37 19 and and CC cord-104317-t30dg6oj 37 20 fall fall VB cord-104317-t30dg6oj 37 21 along along IN cord-104317-t30dg6oj 37 22 a a DT cord-104317-t30dg6oj 37 23 spectrum spectrum NN cord-104317-t30dg6oj 37 24 from from IN cord-104317-t30dg6oj 37 25 exclusively exclusively RB cord-104317-t30dg6oj 37 26 antagonistic antagonistic JJ cord-104317-t30dg6oj 37 27 to to IN cord-104317-t30dg6oj 37 28 exclusively exclusively RB cord-104317-t30dg6oj 37 29 mutualistic mutualistic JJ cord-104317-t30dg6oj 37 30 [ [ -LRB- cord-104317-t30dg6oj 37 31 17 17 CD cord-104317-t30dg6oj 37 32 ] ] -RRB- cord-104317-t30dg6oj 37 33 . . . cord-104317-t30dg6oj 38 1 In in IN cord-104317-t30dg6oj 38 2 general general JJ cord-104317-t30dg6oj 38 3 , , , cord-104317-t30dg6oj 38 4 these these DT cord-104317-t30dg6oj 38 5 interactions interaction NNS cord-104317-t30dg6oj 38 6 are be VBP cord-104317-t30dg6oj 38 7 facultative facultative JJ cord-104317-t30dg6oj 38 8 for for IN cord-104317-t30dg6oj 38 9 the the DT cord-104317-t30dg6oj 38 10 human human NN cord-104317-t30dg6oj 38 11 and and CC cord-104317-t30dg6oj 38 12 obligate obligate VB cord-104317-t30dg6oj 38 13 for for IN cord-104317-t30dg6oj 38 14 the the DT cord-104317-t30dg6oj 38 15 virus virus NN cord-104317-t30dg6oj 38 16 , , , cord-104317-t30dg6oj 38 17 but but CC cord-104317-t30dg6oj 38 18 cases case NNS cord-104317-t30dg6oj 38 19 like like IN cord-104317-t30dg6oj 38 20 the the DT cord-104317-t30dg6oj 38 21 presence presence NN cord-104317-t30dg6oj 38 22 of of IN cord-104317-t30dg6oj 38 23 viral viral JJ cord-104317-t30dg6oj 38 24 sequences sequence NNS cord-104317-t30dg6oj 38 25 in in IN cord-104317-t30dg6oj 38 26 human human JJ cord-104317-t30dg6oj 38 27 genomes genome NNS cord-104317-t30dg6oj 38 28 exemplify exemplify VBP cord-104317-t30dg6oj 38 29 where where WRB cord-104317-t30dg6oj 38 30 this this DT cord-104317-t30dg6oj 38 31 simplistic simplistic JJ cord-104317-t30dg6oj 38 32 view view NN cord-104317-t30dg6oj 38 33 breaks break VBZ cord-104317-t30dg6oj 38 34 down down RP cord-104317-t30dg6oj 38 35 [ [ -LRB- cord-104317-t30dg6oj 38 36 5 5 CD cord-104317-t30dg6oj 38 37 ] ] -RRB- cord-104317-t30dg6oj 38 38 . . . cord-104317-t30dg6oj 39 1 While while IN cord-104317-t30dg6oj 39 2 the the DT cord-104317-t30dg6oj 39 3 position position NN cord-104317-t30dg6oj 39 4 of of IN cord-104317-t30dg6oj 39 5 a a DT cord-104317-t30dg6oj 39 6 particular particular JJ cord-104317-t30dg6oj 39 7 virus virus NN cord-104317-t30dg6oj 39 8 along along IN cord-104317-t30dg6oj 39 9 this this DT cord-104317-t30dg6oj 39 10 spectrum spectrum NN cord-104317-t30dg6oj 39 11 is be VBZ cord-104317-t30dg6oj 39 12 not not RB cord-104317-t30dg6oj 39 13 fixed fix VBN cord-104317-t30dg6oj 39 14 , , , cord-104317-t30dg6oj 39 15 it -PRON- PRP cord-104317-t30dg6oj 39 16 is be VBZ cord-104317-t30dg6oj 39 17 obvious obvious JJ cord-104317-t30dg6oj 39 18 that that IN cord-104317-t30dg6oj 39 19 many many JJ cord-104317-t30dg6oj 39 20 viruses virus NNS cord-104317-t30dg6oj 39 21 have have VBP cord-104317-t30dg6oj 39 22 varied vary VBN cord-104317-t30dg6oj 39 23 , , , cord-104317-t30dg6oj 39 24 intimate intimate JJ cord-104317-t30dg6oj 39 25 relationships relationship NNS cord-104317-t30dg6oj 39 26 with with IN cord-104317-t30dg6oj 39 27 their -PRON- PRP$ cord-104317-t30dg6oj 39 28 hosts host NNS cord-104317-t30dg6oj 39 29 . . . cord-104317-t30dg6oj 40 1 Botanists botanist NNS cord-104317-t30dg6oj 40 2 and and CC cord-104317-t30dg6oj 40 3 entomologists entomologist NNS cord-104317-t30dg6oj 40 4 were be VBD cord-104317-t30dg6oj 40 5 among among IN cord-104317-t30dg6oj 40 6 the the DT cord-104317-t30dg6oj 40 7 first first JJ cord-104317-t30dg6oj 40 8 to to TO cord-104317-t30dg6oj 40 9 notice notice VB cord-104317-t30dg6oj 40 10 the the DT cord-104317-t30dg6oj 40 11 intricacy intricacy NN cord-104317-t30dg6oj 40 12 of of IN cord-104317-t30dg6oj 40 13 virus virus NN cord-104317-t30dg6oj 40 14 - - HYPH cord-104317-t30dg6oj 40 15 host host NN cord-104317-t30dg6oj 40 16 interactions interaction NNS cord-104317-t30dg6oj 40 17 , , , cord-104317-t30dg6oj 40 18 which which WDT cord-104317-t30dg6oj 40 19 challenged challenge VBD cord-104317-t30dg6oj 40 20 the the DT cord-104317-t30dg6oj 40 21 purely purely RB cord-104317-t30dg6oj 40 22 parasitic parasitic JJ cord-104317-t30dg6oj 40 23 dogma dogma NN cord-104317-t30dg6oj 40 24 of of IN cord-104317-t30dg6oj 40 25 virus virus NN cord-104317-t30dg6oj 40 26 - - HYPH cord-104317-t30dg6oj 40 27 host host NN cord-104317-t30dg6oj 40 28 interaction interaction NN cord-104317-t30dg6oj 40 29 ( ( -LRB- cord-104317-t30dg6oj 40 30 reviewed review VBN cord-104317-t30dg6oj 40 31 in in IN cord-104317-t30dg6oj 40 32 [ [ -LRB- cord-104317-t30dg6oj 40 33 17 17 CD cord-104317-t30dg6oj 40 34 ] ] -RRB- cord-104317-t30dg6oj 40 35 [ [ -LRB- cord-104317-t30dg6oj 40 36 18 18 CD cord-104317-t30dg6oj 40 37 ] ] -RRB- cord-104317-t30dg6oj 40 38 [ [ -LRB- cord-104317-t30dg6oj 40 39 19 19 CD cord-104317-t30dg6oj 40 40 ] ] -RRB- cord-104317-t30dg6oj 40 41 [ [ -LRB- cord-104317-t30dg6oj 40 42 20 20 CD cord-104317-t30dg6oj 40 43 ] ] -RRB- cord-104317-t30dg6oj 40 44 ) ) -RRB- cord-104317-t30dg6oj 40 45 . . . cord-104317-t30dg6oj 41 1 For for IN cord-104317-t30dg6oj 41 2 example example NN cord-104317-t30dg6oj 41 3 , , , cord-104317-t30dg6oj 41 4 parasitoid parasitoid NN cord-104317-t30dg6oj 41 5 wasps wasp NNS cord-104317-t30dg6oj 41 6 harboring harbor VBG cord-104317-t30dg6oj 41 7 polydnavirus polydnavirus NNP cord-104317-t30dg6oj 41 8 genomes genome NNS cord-104317-t30dg6oj 41 9 utilize utilize VBP cord-104317-t30dg6oj 41 10 virally virally RB cord-104317-t30dg6oj 41 11 packaged package VBN cord-104317-t30dg6oj 41 12 host host NN cord-104317-t30dg6oj 41 13 genes gene NNS cord-104317-t30dg6oj 41 14 to to TO cord-104317-t30dg6oj 41 15 prevent prevent VB cord-104317-t30dg6oj 41 16 rejection rejection NN cord-104317-t30dg6oj 41 17 of of IN cord-104317-t30dg6oj 41 18 wasp wasp NN cord-104317-t30dg6oj 41 19 eggs egg NNS cord-104317-t30dg6oj 41 20 introduced introduce VBN cord-104317-t30dg6oj 41 21 into into IN cord-104317-t30dg6oj 41 22 the the DT cord-104317-t30dg6oj 41 23 parasitized parasitize VBN cord-104317-t30dg6oj 41 24 caterpillar caterpillar NN cord-104317-t30dg6oj 41 25 [ [ -LRB- cord-104317-t30dg6oj 41 26 21 21 CD cord-104317-t30dg6oj 41 27 ] ] -RRB- cord-104317-t30dg6oj 41 28 . . . cord-104317-t30dg6oj 42 1 In in IN cord-104317-t30dg6oj 42 2 a a DT cord-104317-t30dg6oj 42 3 more more RBR cord-104317-t30dg6oj 42 4 benign benign JJ cord-104317-t30dg6oj 42 5 example example NN cord-104317-t30dg6oj 42 6 , , , cord-104317-t30dg6oj 42 7 the the DT cord-104317-t30dg6oj 42 8 white white JJ cord-104317-t30dg6oj 42 9 clover clover NN cord-104317-t30dg6oj 42 10 suppresses suppress VBZ cord-104317-t30dg6oj 42 11 nodulation nodulation NN cord-104317-t30dg6oj 42 12 in in IN cord-104317-t30dg6oj 42 13 conditions condition NNS cord-104317-t30dg6oj 42 14 of of IN cord-104317-t30dg6oj 42 15 sufficient sufficient JJ cord-104317-t30dg6oj 42 16 nitrogen nitrogen NN cord-104317-t30dg6oj 42 17 in in IN cord-104317-t30dg6oj 42 18 a a DT cord-104317-t30dg6oj 42 19 manner manner NN cord-104317-t30dg6oj 42 20 dependent dependent JJ cord-104317-t30dg6oj 42 21 on on IN cord-104317-t30dg6oj 42 22 viral viral JJ cord-104317-t30dg6oj 42 23 coat coat NN cord-104317-t30dg6oj 42 24 proteins protein NNS cord-104317-t30dg6oj 42 25 of of IN cord-104317-t30dg6oj 42 26 a a DT cord-104317-t30dg6oj 42 27 persistently persistently RB cord-104317-t30dg6oj 42 28 infecting infect VBG cord-104317-t30dg6oj 42 29 cryptic cryptic JJ cord-104317-t30dg6oj 42 30 virus virus NN cord-104317-t30dg6oj 42 31 [ [ -LRB- cord-104317-t30dg6oj 42 32 22 22 CD cord-104317-t30dg6oj 42 33 ] ] -RRB- cord-104317-t30dg6oj 42 34 . . . cord-104317-t30dg6oj 43 1 While while IN cord-104317-t30dg6oj 43 2 the the DT cord-104317-t30dg6oj 43 3 breadth breadth NN cord-104317-t30dg6oj 43 4 of of IN cord-104317-t30dg6oj 43 5 knowledge knowledge NN cord-104317-t30dg6oj 43 6 of of IN cord-104317-t30dg6oj 43 7 interactions interaction NNS cord-104317-t30dg6oj 43 8 types type NNS cord-104317-t30dg6oj 43 9 is be VBZ cord-104317-t30dg6oj 43 10 surely surely RB cord-104317-t30dg6oj 43 11 incomplete incomplete JJ cord-104317-t30dg6oj 43 12 , , , cord-104317-t30dg6oj 43 13 their -PRON- PRP$ cord-104317-t30dg6oj 43 14 presence presence NN cord-104317-t30dg6oj 43 15 in in IN cord-104317-t30dg6oj 43 16 other other JJ cord-104317-t30dg6oj 43 17 organisms organism NNS cord-104317-t30dg6oj 43 18 al al NNP cord-104317-t30dg6oj 43 19 - - HYPH cord-104317-t30dg6oj 43 20 ludes ludes NNP cord-104317-t30dg6oj 43 21 to to IN cord-104317-t30dg6oj 43 22 the the DT cord-104317-t30dg6oj 43 23 possibility possibility NN cord-104317-t30dg6oj 43 24 of of IN cord-104317-t30dg6oj 43 25 the the DT cord-104317-t30dg6oj 43 26 existence existence NN cord-104317-t30dg6oj 43 27 of of IN cord-104317-t30dg6oj 43 28 similar similar JJ cord-104317-t30dg6oj 43 29 interactions interaction NNS cord-104317-t30dg6oj 43 30 between between IN cord-104317-t30dg6oj 43 31 humans human NNS cord-104317-t30dg6oj 43 32 and and CC cord-104317-t30dg6oj 43 33 viruses virus NNS cord-104317-t30dg6oj 43 34 . . . cord-104317-t30dg6oj 44 1 Recent recent JJ cord-104317-t30dg6oj 44 2 reviews review NNS cord-104317-t30dg6oj 44 3 have have VBP cord-104317-t30dg6oj 44 4 addressed address VBN cord-104317-t30dg6oj 44 5 the the DT cord-104317-t30dg6oj 44 6 issue issue NN cord-104317-t30dg6oj 44 7 of of IN cord-104317-t30dg6oj 44 8 the the DT cord-104317-t30dg6oj 44 9 current current JJ cord-104317-t30dg6oj 44 10 , , , cord-104317-t30dg6oj 44 11 primarily primarily RB cord-104317-t30dg6oj 44 12 negative negative JJ cord-104317-t30dg6oj 44 13 , , , cord-104317-t30dg6oj 44 14 view view NN cord-104317-t30dg6oj 44 15 of of IN cord-104317-t30dg6oj 44 16 the the DT cord-104317-t30dg6oj 44 17 human human JJ cord-104317-t30dg6oj 44 18 virome virome NNP cord-104317-t30dg6oj 44 19 [ [ -LRB- cord-104317-t30dg6oj 44 20 18 18 CD cord-104317-t30dg6oj 44 21 , , , cord-104317-t30dg6oj 44 22 [ [ -LRB- cord-104317-t30dg6oj 44 23 23 23 CD cord-104317-t30dg6oj 44 24 ] ] -RRB- cord-104317-t30dg6oj 44 25 [ [ -LRB- cord-104317-t30dg6oj 44 26 24 24 CD cord-104317-t30dg6oj 44 27 ] ] -RRB- cord-104317-t30dg6oj 44 28 [ [ -LRB- cord-104317-t30dg6oj 44 29 25 25 CD cord-104317-t30dg6oj 44 30 ] ] -RRB- cord-104317-t30dg6oj 44 31 [ [ -LRB- cord-104317-t30dg6oj 44 32 26 26 CD cord-104317-t30dg6oj 44 33 ] ] -RRB- cord-104317-t30dg6oj 44 34 . . . cord-104317-t30dg6oj 45 1 Virologists virologist NNS cord-104317-t30dg6oj 45 2 are be VBP cord-104317-t30dg6oj 45 3 beginning begin VBG cord-104317-t30dg6oj 45 4 to to TO cord-104317-t30dg6oj 45 5 realize realize VB cord-104317-t30dg6oj 45 6 that that IN cord-104317-t30dg6oj 45 7 the the DT cord-104317-t30dg6oj 45 8 viruses virus NNS cord-104317-t30dg6oj 45 9 within within IN cord-104317-t30dg6oj 45 10 us -PRON- PRP cord-104317-t30dg6oj 45 11 may may MD cord-104317-t30dg6oj 45 12 be be VB cord-104317-t30dg6oj 45 13 more more RBR cord-104317-t30dg6oj 45 14 important important JJ cord-104317-t30dg6oj 45 15 than than IN cord-104317-t30dg6oj 45 16 previously previously RB cord-104317-t30dg6oj 45 17 appreciated appreciate VBN cord-104317-t30dg6oj 45 18 . . . cord-104317-t30dg6oj 46 1 The the DT cord-104317-t30dg6oj 46 2 discovery discovery NN cord-104317-t30dg6oj 46 3 of of IN cord-104317-t30dg6oj 46 4 intimate intimate JJ cord-104317-t30dg6oj 46 5 interactions interaction NNS cord-104317-t30dg6oj 46 6 of of IN cord-104317-t30dg6oj 46 7 viruses virus NNS cord-104317-t30dg6oj 46 8 with with IN cord-104317-t30dg6oj 46 9 humans human NNS cord-104317-t30dg6oj 46 10 , , , cord-104317-t30dg6oj 46 11 like like IN cord-104317-t30dg6oj 46 12 the the DT cord-104317-t30dg6oj 46 13 role role NN cord-104317-t30dg6oj 46 14 of of IN cord-104317-t30dg6oj 46 15 endogenous endogenous JJ cord-104317-t30dg6oj 46 16 retrovirus retrovirus NN cord-104317-t30dg6oj 46 17 ( ( -LRB- cord-104317-t30dg6oj 46 18 ERV ERV NNP cord-104317-t30dg6oj 46 19 † † NNP cord-104317-t30dg6oj 46 20 ) ) -RRB- cord-104317-t30dg6oj 46 21 syncytins syncytin NNS cord-104317-t30dg6oj 46 22 in in IN cord-104317-t30dg6oj 46 23 placentation placentation NN cord-104317-t30dg6oj 46 24 [ [ -LRB- cord-104317-t30dg6oj 46 25 27 27 CD cord-104317-t30dg6oj 46 26 ] ] -RRB- cord-104317-t30dg6oj 46 27 , , , cord-104317-t30dg6oj 46 28 are be VBP cord-104317-t30dg6oj 46 29 categorically categorically RB cord-104317-t30dg6oj 46 30 dissimilar dissimilar JJ cord-104317-t30dg6oj 46 31 to to IN cord-104317-t30dg6oj 46 32 the the DT cord-104317-t30dg6oj 46 33 classical classical JJ cord-104317-t30dg6oj 46 34 view view NN cord-104317-t30dg6oj 46 35 of of IN cord-104317-t30dg6oj 46 36 viruses virus NNS cord-104317-t30dg6oj 46 37 only only RB cord-104317-t30dg6oj 46 38 as as IN cord-104317-t30dg6oj 46 39 parasites parasite NNS cord-104317-t30dg6oj 46 40 and and CC cord-104317-t30dg6oj 46 41 brings bring VBZ cord-104317-t30dg6oj 46 42 to to TO cord-104317-t30dg6oj 46 43 issue issue VB cord-104317-t30dg6oj 46 44 how how WRB cord-104317-t30dg6oj 46 45 scientists scientist NNS cord-104317-t30dg6oj 46 46 are be VBP cord-104317-t30dg6oj 46 47 approaching approach VBG cord-104317-t30dg6oj 46 48 the the DT cord-104317-t30dg6oj 46 49 study study NN cord-104317-t30dg6oj 46 50 of of IN cord-104317-t30dg6oj 46 51 the the DT cord-104317-t30dg6oj 46 52 virome virome NNP cord-104317-t30dg6oj 46 53 . . . cord-104317-t30dg6oj 47 1 A a DT cord-104317-t30dg6oj 47 2 lack lack NN cord-104317-t30dg6oj 47 3 of of IN cord-104317-t30dg6oj 47 4 structure structure NN cord-104317-t30dg6oj 47 5 in in IN cord-104317-t30dg6oj 47 6 this this DT cord-104317-t30dg6oj 47 7 endeavor endeavor NN cord-104317-t30dg6oj 47 8 has have VBZ cord-104317-t30dg6oj 47 9 arguably arguably RB cord-104317-t30dg6oj 47 10 hindered hinder VBN cord-104317-t30dg6oj 47 11 the the DT cord-104317-t30dg6oj 47 12 true true JJ cord-104317-t30dg6oj 47 13 understanding understanding NN cord-104317-t30dg6oj 47 14 of of IN cord-104317-t30dg6oj 47 15 non non JJ cord-104317-t30dg6oj 47 16 - - JJ cord-104317-t30dg6oj 47 17 pathogenic pathogenic JJ cord-104317-t30dg6oj 47 18 consequences consequence NNS cord-104317-t30dg6oj 47 19 of of IN cord-104317-t30dg6oj 47 20 human human NN cord-104317-t30dg6oj 47 21 - - HYPH cord-104317-t30dg6oj 47 22 virome virome NN cord-104317-t30dg6oj 47 23 interactions interaction NNS cord-104317-t30dg6oj 47 24 . . . cord-104317-t30dg6oj 48 1 To to TO cord-104317-t30dg6oj 48 2 address address VB cord-104317-t30dg6oj 48 3 this this DT cord-104317-t30dg6oj 48 4 issue issue NN cord-104317-t30dg6oj 48 5 , , , cord-104317-t30dg6oj 48 6 an an DT cord-104317-t30dg6oj 48 7 ecological ecological JJ cord-104317-t30dg6oj 48 8 framework framework NN cord-104317-t30dg6oj 48 9 can can MD cord-104317-t30dg6oj 48 10 be be VB cord-104317-t30dg6oj 48 11 constructed construct VBN cord-104317-t30dg6oj 48 12 for for IN cord-104317-t30dg6oj 48 13 more more RBR cord-104317-t30dg6oj 48 14 informative informative JJ cord-104317-t30dg6oj 48 15 classification classification NN cord-104317-t30dg6oj 48 16 of of IN cord-104317-t30dg6oj 48 17 the the DT cord-104317-t30dg6oj 48 18 virome virome NN cord-104317-t30dg6oj 48 19 based base VBN cord-104317-t30dg6oj 48 20 on on IN cord-104317-t30dg6oj 48 21 how how WRB cord-104317-t30dg6oj 48 22 viruses virus NNS cord-104317-t30dg6oj 48 23 fill fill VBP cord-104317-t30dg6oj 48 24 niches niche NNS cord-104317-t30dg6oj 48 25 in in IN cord-104317-t30dg6oj 48 26 humans human NNS cord-104317-t30dg6oj 48 27 . . . cord-104317-t30dg6oj 49 1 Here here RB cord-104317-t30dg6oj 49 2 , , , cord-104317-t30dg6oj 49 3 I -PRON- PRP cord-104317-t30dg6oj 49 4 describe describe VBP cord-104317-t30dg6oj 49 5 a a DT cord-104317-t30dg6oj 49 6 conception conception NN cord-104317-t30dg6oj 49 7 of of IN cord-104317-t30dg6oj 49 8 the the DT cord-104317-t30dg6oj 49 9 human human JJ cord-104317-t30dg6oj 49 10 virome virome NN cord-104317-t30dg6oj 49 11 with with IN cord-104317-t30dg6oj 49 12 three three CD cord-104317-t30dg6oj 49 13 general general JJ cord-104317-t30dg6oj 49 14 classifications classification NNS cord-104317-t30dg6oj 49 15 of of IN cord-104317-t30dg6oj 49 16 virus virus NN cord-104317-t30dg6oj 49 17 types type NNS cord-104317-t30dg6oj 49 18 : : : cord-104317-t30dg6oj 49 19 Parasitic parasitic JJ cord-104317-t30dg6oj 49 20 , , , cord-104317-t30dg6oj 49 21 Commensal Commensal NNP cord-104317-t30dg6oj 49 22 , , , cord-104317-t30dg6oj 49 23 and and CC cord-104317-t30dg6oj 49 24 Mutualistic Mutualistic NNP cord-104317-t30dg6oj 49 25 ( ( -LRB- cord-104317-t30dg6oj 49 26 Figure figure NN cord-104317-t30dg6oj 49 27 1 1 CD cord-104317-t30dg6oj 49 28 ) ) -RRB- cord-104317-t30dg6oj 49 29 . . . cord-104317-t30dg6oj 50 1 Within within IN cord-104317-t30dg6oj 50 2 these these DT cord-104317-t30dg6oj 50 3 groupings grouping NNS cord-104317-t30dg6oj 50 4 are be VBP cord-104317-t30dg6oj 50 5 subcategories subcategorie NNS cord-104317-t30dg6oj 50 6 containing contain VBG cord-104317-t30dg6oj 50 7 more more RBR cord-104317-t30dg6oj 50 8 specific specific JJ cord-104317-t30dg6oj 50 9 characteristics characteristic NNS cord-104317-t30dg6oj 50 10 germane germane JJ cord-104317-t30dg6oj 50 11 to to IN cord-104317-t30dg6oj 50 12 different different JJ cord-104317-t30dg6oj 50 13 viral viral JJ cord-104317-t30dg6oj 50 14 groups group NNS cord-104317-t30dg6oj 50 15 . . . cord-104317-t30dg6oj 51 1 Table table NN cord-104317-t30dg6oj 51 2 1 1 CD cord-104317-t30dg6oj 51 3 illustrates illustrate VBZ cord-104317-t30dg6oj 51 4 how how WRB cord-104317-t30dg6oj 51 5 representative representative JJ cord-104317-t30dg6oj 51 6 members member NNS cord-104317-t30dg6oj 51 7 of of IN cord-104317-t30dg6oj 51 8 the the DT cord-104317-t30dg6oj 51 9 human human JJ cord-104317-t30dg6oj 51 10 virome virome NN cord-104317-t30dg6oj 51 11 spanning span VBG cord-104317-t30dg6oj 51 12 a a DT cord-104317-t30dg6oj 51 13 vast vast JJ cord-104317-t30dg6oj 51 14 array array NN cord-104317-t30dg6oj 51 15 of of IN cord-104317-t30dg6oj 51 16 families family NNS cord-104317-t30dg6oj 51 17 , , , cord-104317-t30dg6oj 51 18 replication replication NN cord-104317-t30dg6oj 51 19 schemes scheme NNS cord-104317-t30dg6oj 51 20 , , , cord-104317-t30dg6oj 51 21 genome genome NN cord-104317-t30dg6oj 51 22 architectures architecture NNS cord-104317-t30dg6oj 51 23 , , , cord-104317-t30dg6oj 51 24 and and CC cord-104317-t30dg6oj 51 25 tropisms tropism NNS cord-104317-t30dg6oj 51 26 can can MD cord-104317-t30dg6oj 51 27 be be VB cord-104317-t30dg6oj 51 28 succinctly succinctly RB cord-104317-t30dg6oj 51 29 classified classify VBN cord-104317-t30dg6oj 51 30 with with IN cord-104317-t30dg6oj 51 31 this this DT cord-104317-t30dg6oj 51 32 scheme scheme NN cord-104317-t30dg6oj 51 33 . . . cord-104317-t30dg6oj 52 1 This this DT cord-104317-t30dg6oj 52 2 arrangement arrangement NN cord-104317-t30dg6oj 52 3 provides provide VBZ cord-104317-t30dg6oj 52 4 functional functional JJ cord-104317-t30dg6oj 52 5 information information NN cord-104317-t30dg6oj 52 6 about about IN cord-104317-t30dg6oj 52 7 the the DT cord-104317-t30dg6oj 52 8 nature nature NN cord-104317-t30dg6oj 52 9 and and CC cord-104317-t30dg6oj 52 10 plasticity plasticity NN cord-104317-t30dg6oj 52 11 of of IN cord-104317-t30dg6oj 52 12 virus virus NN cord-104317-t30dg6oj 52 13 - - HYPH cord-104317-t30dg6oj 52 14 host host NN cord-104317-t30dg6oj 52 15 interaction interaction NN cord-104317-t30dg6oj 52 16 , , , cord-104317-t30dg6oj 52 17 the the DT cord-104317-t30dg6oj 52 18 most most RBS cord-104317-t30dg6oj 52 19 critical critical JJ cord-104317-t30dg6oj 52 20 defining define VBG cord-104317-t30dg6oj 52 21 characteristic characteristic NN cord-104317-t30dg6oj 52 22 of of IN cord-104317-t30dg6oj 52 23 a a DT cord-104317-t30dg6oj 52 24 virus virus NN cord-104317-t30dg6oj 52 25 in in IN cord-104317-t30dg6oj 52 26 the the DT cord-104317-t30dg6oj 52 27 context context NN cord-104317-t30dg6oj 52 28 of of IN cord-104317-t30dg6oj 52 29 human human JJ cord-104317-t30dg6oj 52 30 health health NN cord-104317-t30dg6oj 52 31 , , , cord-104317-t30dg6oj 52 32 in in IN cord-104317-t30dg6oj 52 33 a a DT cord-104317-t30dg6oj 52 34 way way NN cord-104317-t30dg6oj 52 35 absent absent JJ cord-104317-t30dg6oj 52 36 in in IN cord-104317-t30dg6oj 52 37 the the DT cord-104317-t30dg6oj 52 38 more more RBR cord-104317-t30dg6oj 52 39 classical classical JJ cord-104317-t30dg6oj 52 40 types type NNS cord-104317-t30dg6oj 52 41 of of IN cord-104317-t30dg6oj 52 42 organization organization NN cord-104317-t30dg6oj 52 43 mentioned mention VBN cord-104317-t30dg6oj 52 44 above above RB cord-104317-t30dg6oj 52 45 . . . cord-104317-t30dg6oj 53 1 In in IN cord-104317-t30dg6oj 53 2 the the DT cord-104317-t30dg6oj 53 3 rest rest NN cord-104317-t30dg6oj 53 4 of of IN cord-104317-t30dg6oj 53 5 this this DT cord-104317-t30dg6oj 53 6 review review NN cord-104317-t30dg6oj 53 7 , , , cord-104317-t30dg6oj 53 8 I -PRON- PRP cord-104317-t30dg6oj 53 9 will will MD cord-104317-t30dg6oj 53 10 characterize characterize VB cord-104317-t30dg6oj 53 11 each each DT cord-104317-t30dg6oj 53 12 grouping grouping NN cord-104317-t30dg6oj 53 13 and and CC cord-104317-t30dg6oj 53 14 provide provide VB cord-104317-t30dg6oj 53 15 examples example NNS cord-104317-t30dg6oj 53 16 from from IN cord-104317-t30dg6oj 53 17 the the DT cord-104317-t30dg6oj 53 18 literature literature NN cord-104317-t30dg6oj 53 19 supporting support VBG cord-104317-t30dg6oj 53 20 this this DT cord-104317-t30dg6oj 53 21 classification classification NN cord-104317-t30dg6oj 53 22 . . . cord-104317-t30dg6oj 54 1 The the DT cord-104317-t30dg6oj 54 2 application application NN cord-104317-t30dg6oj 54 3 of of IN cord-104317-t30dg6oj 54 4 this this DT cord-104317-t30dg6oj 54 5 scaffold scaffold NN cord-104317-t30dg6oj 54 6 will will MD cord-104317-t30dg6oj 54 7 not not RB cord-104317-t30dg6oj 54 8 only only RB cord-104317-t30dg6oj 54 9 deepen deepen VB cord-104317-t30dg6oj 54 10 the the DT cord-104317-t30dg6oj 54 11 understanding understanding NN cord-104317-t30dg6oj 54 12 of of IN cord-104317-t30dg6oj 54 13 known know VBN cord-104317-t30dg6oj 54 14 virus virus NN cord-104317-t30dg6oj 54 15 - - HYPH cord-104317-t30dg6oj 54 16 host host NN cord-104317-t30dg6oj 54 17 interactions interaction NNS cord-104317-t30dg6oj 54 18 in in IN cord-104317-t30dg6oj 54 19 the the DT cord-104317-t30dg6oj 54 20 ecological ecological JJ cord-104317-t30dg6oj 54 21 context context NN cord-104317-t30dg6oj 54 22 of of IN cord-104317-t30dg6oj 54 23 the the DT cord-104317-t30dg6oj 54 24 virome virome NN cord-104317-t30dg6oj 54 25 , , , cord-104317-t30dg6oj 54 26 but but CC cord-104317-t30dg6oj 54 27 will will MD cord-104317-t30dg6oj 54 28 also also RB cord-104317-t30dg6oj 54 29 identify identify VB cord-104317-t30dg6oj 54 30 logical logical JJ cord-104317-t30dg6oj 54 31 next next JJ cord-104317-t30dg6oj 54 32 steps step NNS cord-104317-t30dg6oj 54 33 and and CC cord-104317-t30dg6oj 54 34 gaps gap NNS cord-104317-t30dg6oj 54 35 in in IN cord-104317-t30dg6oj 54 36 current current JJ cord-104317-t30dg6oj 54 37 knowledge knowledge NN cord-104317-t30dg6oj 54 38 that that WDT cord-104317-t30dg6oj 54 39 are be VBP cord-104317-t30dg6oj 54 40 tantalizing tantalizing JJ cord-104317-t30dg6oj 54 41 areas area NNS cord-104317-t30dg6oj 54 42 for for IN cord-104317-t30dg6oj 54 43 future future JJ cord-104317-t30dg6oj 54 44 exploration exploration NN cord-104317-t30dg6oj 54 45 . . . cord-104317-t30dg6oj 55 1 The the DT cord-104317-t30dg6oj 55 2 canonical canonical JJ cord-104317-t30dg6oj 55 3 classification classification NN cord-104317-t30dg6oj 55 4 of of IN cord-104317-t30dg6oj 55 5 viruses virus NNS cord-104317-t30dg6oj 55 6 is be VBZ cord-104317-t30dg6oj 55 7 as as IN cord-104317-t30dg6oj 55 8 parasites parasite NNS cord-104317-t30dg6oj 55 9 . . . cord-104317-t30dg6oj 56 1 In in IN cord-104317-t30dg6oj 56 2 general general JJ cord-104317-t30dg6oj 56 3 , , , cord-104317-t30dg6oj 56 4 parasitic parasitic JJ cord-104317-t30dg6oj 56 5 viruses virus NNS cord-104317-t30dg6oj 56 6 are be VBP cord-104317-t30dg6oj 56 7 transmitted transmit VBN cord-104317-t30dg6oj 56 8 horizontally horizontally RB cord-104317-t30dg6oj 56 9 from from IN cord-104317-t30dg6oj 56 10 host host NN cord-104317-t30dg6oj 56 11 to to IN cord-104317-t30dg6oj 56 12 host host VB cord-104317-t30dg6oj 56 13 , , , cord-104317-t30dg6oj 56 14 and and CC cord-104317-t30dg6oj 56 15 this this DT cord-104317-t30dg6oj 56 16 process process NN cord-104317-t30dg6oj 56 17 is be VBZ cord-104317-t30dg6oj 56 18 necessary necessary JJ cord-104317-t30dg6oj 56 19 for for IN cord-104317-t30dg6oj 56 20 the the DT cord-104317-t30dg6oj 56 21 virus virus NN cord-104317-t30dg6oj 56 22 ' ' '' cord-104317-t30dg6oj 56 23 survival survival NN cord-104317-t30dg6oj 56 24 . . . cord-104317-t30dg6oj 57 1 Their -PRON- PRP$ cord-104317-t30dg6oj 57 2 obligate obligate JJ cord-104317-t30dg6oj 57 3 life life NN cord-104317-t30dg6oj 57 4 cycles cycle NNS cord-104317-t30dg6oj 57 5 necessitate necessitate VBP cord-104317-t30dg6oj 57 6 manipulation manipulation NN cord-104317-t30dg6oj 57 7 of of IN cord-104317-t30dg6oj 57 8 cellular cellular JJ cord-104317-t30dg6oj 57 9 processes process NNS cord-104317-t30dg6oj 57 10 and and CC cord-104317-t30dg6oj 57 11 have have VBP cord-104317-t30dg6oj 57 12 been be VBN cord-104317-t30dg6oj 57 13 classically classically RB cord-104317-t30dg6oj 57 14 linked link VBN cord-104317-t30dg6oj 57 15 to to IN cord-104317-t30dg6oj 57 16 disease disease NN cord-104317-t30dg6oj 57 17 manifestation manifestation NN cord-104317-t30dg6oj 57 18 . . . cord-104317-t30dg6oj 58 1 While while IN cord-104317-t30dg6oj 58 2 the the DT cord-104317-t30dg6oj 58 3 role role NN cord-104317-t30dg6oj 58 4 of of IN cord-104317-t30dg6oj 58 5 viruses virus NNS cord-104317-t30dg6oj 58 6 in in IN cord-104317-t30dg6oj 58 7 human human JJ cord-104317-t30dg6oj 58 8 disease disease NN cord-104317-t30dg6oj 58 9 was be VBD cord-104317-t30dg6oj 58 10 not not RB cord-104317-t30dg6oj 58 11 appreciated appreciate VBN cord-104317-t30dg6oj 58 12 until until IN cord-104317-t30dg6oj 58 13 the the DT cord-104317-t30dg6oj 58 14 19th 19th JJ cord-104317-t30dg6oj 58 15 century century NN cord-104317-t30dg6oj 58 16 [ [ -LRB- cord-104317-t30dg6oj 58 17 28 28 CD cord-104317-t30dg6oj 58 18 ] ] -RRB- cord-104317-t30dg6oj 58 19 , , , cord-104317-t30dg6oj 58 20 throughout throughout IN cord-104317-t30dg6oj 58 21 human human JJ cord-104317-t30dg6oj 58 22 history history NN cord-104317-t30dg6oj 58 23 , , , cord-104317-t30dg6oj 58 24 the the DT cord-104317-t30dg6oj 58 25 diseases disease NNS cord-104317-t30dg6oj 58 26 caused cause VBN cord-104317-t30dg6oj 58 27 by by IN cord-104317-t30dg6oj 58 28 particularly particularly RB cord-104317-t30dg6oj 58 29 pathogenic pathogenic JJ cord-104317-t30dg6oj 58 30 viruses virus NNS cord-104317-t30dg6oj 58 31 have have VBP cord-104317-t30dg6oj 58 32 been be VBN cord-104317-t30dg6oj 58 33 some some DT cord-104317-t30dg6oj 58 34 of of IN cord-104317-t30dg6oj 58 35 the the DT cord-104317-t30dg6oj 58 36 most most RBS cord-104317-t30dg6oj 58 37 feared fear VBN cord-104317-t30dg6oj 58 38 and and CC cord-104317-t30dg6oj 58 39 deadly deadly JJ cord-104317-t30dg6oj 58 40 . . . cord-104317-t30dg6oj 59 1 Currently currently RB cord-104317-t30dg6oj 59 2 , , , cord-104317-t30dg6oj 59 3 there there EX cord-104317-t30dg6oj 59 4 are be VBP cord-104317-t30dg6oj 59 5 129 129 CD cord-104317-t30dg6oj 59 6 known know VBN cord-104317-t30dg6oj 59 7 human human JJ cord-104317-t30dg6oj 59 8 viral viral JJ cord-104317-t30dg6oj 59 9 pathogens pathogen NNS cord-104317-t30dg6oj 59 10 [ [ -LRB- cord-104317-t30dg6oj 59 11 29 29 CD cord-104317-t30dg6oj 59 12 ] ] -RRB- cord-104317-t30dg6oj 59 13 and and CC cord-104317-t30dg6oj 59 14 at at IN cord-104317-t30dg6oj 59 15 least least JJS cord-104317-t30dg6oj 59 16 219 219 CD cord-104317-t30dg6oj 59 17 viruses virus NNS cord-104317-t30dg6oj 59 18 that that WDT cord-104317-t30dg6oj 59 19 can can MD cord-104317-t30dg6oj 59 20 infect infect VB cord-104317-t30dg6oj 59 21 humans human NNS cord-104317-t30dg6oj 59 22 [ [ -LRB- cord-104317-t30dg6oj 59 23 30 30 CD cord-104317-t30dg6oj 59 24 ] ] -RRB- cord-104317-t30dg6oj 59 25 , , , cord-104317-t30dg6oj 59 26 with with IN cord-104317-t30dg6oj 59 27 more more JJR cord-104317-t30dg6oj 59 28 being be VBG cord-104317-t30dg6oj 59 29 discovered discover VBN cord-104317-t30dg6oj 59 30 every every DT cord-104317-t30dg6oj 59 31 year year NN cord-104317-t30dg6oj 59 32 [ [ -LRB- cord-104317-t30dg6oj 59 33 31 31 CD cord-104317-t30dg6oj 59 34 , , , cord-104317-t30dg6oj 59 35 32 32 CD cord-104317-t30dg6oj 59 36 ] ] -RRB- cord-104317-t30dg6oj 59 37 . . . cord-104317-t30dg6oj 60 1 The the DT cord-104317-t30dg6oj 60 2 apparent apparent JJ cord-104317-t30dg6oj 60 3 bias bias NN cord-104317-t30dg6oj 60 4 toward toward IN cord-104317-t30dg6oj 60 5 pathogenic pathogenic JJ cord-104317-t30dg6oj 60 6 species specie NNS cord-104317-t30dg6oj 60 7 is be VBZ cord-104317-t30dg6oj 60 8 undeniably undeniably RB cord-104317-t30dg6oj 60 9 because because IN cord-104317-t30dg6oj 60 10 phenotype phenotype NN cord-104317-t30dg6oj 60 11 ( ( -LRB- cord-104317-t30dg6oj 60 12 read read VB cord-104317-t30dg6oj 60 13 : : : cord-104317-t30dg6oj 60 14 pathogenesis pathogenesis NN cord-104317-t30dg6oj 60 15 ) ) -RRB- cord-104317-t30dg6oj 60 16 has have VBZ cord-104317-t30dg6oj 60 17 traditionally traditionally RB cord-104317-t30dg6oj 60 18 been be VBN cord-104317-t30dg6oj 60 19 a a DT cord-104317-t30dg6oj 60 20 major major JJ cord-104317-t30dg6oj 60 21 factor factor NN cord-104317-t30dg6oj 60 22 in in IN cord-104317-t30dg6oj 60 23 the the DT cord-104317-t30dg6oj 60 24 discovery discovery NN cord-104317-t30dg6oj 60 25 of of IN cord-104317-t30dg6oj 60 26 new new JJ cord-104317-t30dg6oj 60 27 viruses virus NNS cord-104317-t30dg6oj 60 28 . . . cord-104317-t30dg6oj 61 1 While while IN cord-104317-t30dg6oj 61 2 parasitic parasitic JJ cord-104317-t30dg6oj 61 3 viruses virus NNS cord-104317-t30dg6oj 61 4 are be VBP cord-104317-t30dg6oj 61 5 a a DT cord-104317-t30dg6oj 61 6 morose morose JJ cord-104317-t30dg6oj 61 7 facet facet NN cord-104317-t30dg6oj 61 8 of of IN cord-104317-t30dg6oj 61 9 human human JJ cord-104317-t30dg6oj 61 10 history history NN cord-104317-t30dg6oj 61 11 , , , cord-104317-t30dg6oj 61 12 they -PRON- PRP cord-104317-t30dg6oj 61 13 have have VBP cord-104317-t30dg6oj 61 14 contributed contribute VBN cord-104317-t30dg6oj 61 15 to to TO cord-104317-t30dg6oj 61 16 man man VB cord-104317-t30dg6oj 61 17 's 's POS cord-104317-t30dg6oj 61 18 evolution evolution NN cord-104317-t30dg6oj 61 19 as as IN cord-104317-t30dg6oj 61 20 a a DT cord-104317-t30dg6oj 61 21 species species NN cord-104317-t30dg6oj 61 22 . . . cord-104317-t30dg6oj 62 1 The the DT cord-104317-t30dg6oj 62 2 biologist biologist NN cord-104317-t30dg6oj 62 3 's 's POS cord-104317-t30dg6oj 62 4 viewpoint viewpoint NN cord-104317-t30dg6oj 62 5 includes include VBZ cord-104317-t30dg6oj 62 6 the the DT cord-104317-t30dg6oj 62 7 selective selective JJ cord-104317-t30dg6oj 62 8 pressure pressure NN cord-104317-t30dg6oj 62 9 on on IN cord-104317-t30dg6oj 62 10 man man NN cord-104317-t30dg6oj 62 11 in in IN cord-104317-t30dg6oj 62 12 which which WDT cord-104317-t30dg6oj 62 13 viruses virus NNS cord-104317-t30dg6oj 62 14 kill kill VBP cord-104317-t30dg6oj 62 15 susceptible susceptible JJ cord-104317-t30dg6oj 62 16 hosts host NNS cord-104317-t30dg6oj 62 17 , , , cord-104317-t30dg6oj 62 18 leading lead VBG cord-104317-t30dg6oj 62 19 to to IN cord-104317-t30dg6oj 62 20 the the DT cord-104317-t30dg6oj 62 21 emergence emergence NN cord-104317-t30dg6oj 62 22 of of IN cord-104317-t30dg6oj 62 23 fitter fitter NN cord-104317-t30dg6oj 62 24 genotypes genotype NNS cord-104317-t30dg6oj 62 25 . . . cord-104317-t30dg6oj 63 1 Some some DT cord-104317-t30dg6oj 63 2 viruses virus NNS cord-104317-t30dg6oj 63 3 play play VBP cord-104317-t30dg6oj 63 4 a a DT cord-104317-t30dg6oj 63 5 similar similar JJ cord-104317-t30dg6oj 63 6 role role NN cord-104317-t30dg6oj 63 7 by by IN cord-104317-t30dg6oj 63 8 limiting limit VBG cord-104317-t30dg6oj 63 9 an an DT cord-104317-t30dg6oj 63 10 infected infected JJ cord-104317-t30dg6oj 63 11 host host NN cord-104317-t30dg6oj 63 12 's 's POS cord-104317-t30dg6oj 63 13 reproductive reproductive JJ cord-104317-t30dg6oj 63 14 fitness fitness NN cord-104317-t30dg6oj 63 15 [ [ -LRB- cord-104317-t30dg6oj 63 16 33 33 CD cord-104317-t30dg6oj 63 17 ] ] -RRB- cord-104317-t30dg6oj 63 18 . . . cord-104317-t30dg6oj 64 1 The the DT cord-104317-t30dg6oj 64 2 presence presence NN cord-104317-t30dg6oj 64 3 of of IN cord-104317-t30dg6oj 64 4 deadly deadly JJ cord-104317-t30dg6oj 64 5 viruses virus NNS cord-104317-t30dg6oj 64 6 has have VBZ cord-104317-t30dg6oj 64 7 also also RB cord-104317-t30dg6oj 64 8 supplied supply VBN cord-104317-t30dg6oj 64 9 pressure pressure NN cord-104317-t30dg6oj 64 10 for for IN cord-104317-t30dg6oj 64 11 behavioral behavioral JJ cord-104317-t30dg6oj 64 12 and and CC cord-104317-t30dg6oj 64 13 psychological psychological JJ cord-104317-t30dg6oj 64 14 adaptation adaptation NN cord-104317-t30dg6oj 64 15 via via IN cord-104317-t30dg6oj 64 16 influence influence NN cord-104317-t30dg6oj 64 17 on on IN cord-104317-t30dg6oj 64 18 practices practice NNS cord-104317-t30dg6oj 64 19 in in IN cord-104317-t30dg6oj 64 20 mate mate NN cord-104317-t30dg6oj 64 21 selection selection NN cord-104317-t30dg6oj 64 22 , , , cord-104317-t30dg6oj 64 23 food food NN cord-104317-t30dg6oj 64 24 preparation preparation NN cord-104317-t30dg6oj 64 25 , , , cord-104317-t30dg6oj 64 26 and and CC cord-104317-t30dg6oj 64 27 sanitation sanitation NN cord-104317-t30dg6oj 64 28 [ [ -LRB- cord-104317-t30dg6oj 64 29 34 34 CD cord-104317-t30dg6oj 64 30 ] ] -RRB- cord-104317-t30dg6oj 64 31 . . . cord-104317-t30dg6oj 65 1 A a DT cord-104317-t30dg6oj 65 2 modern modern JJ cord-104317-t30dg6oj 65 3 example example NN cord-104317-t30dg6oj 65 4 of of IN cord-104317-t30dg6oj 65 5 such such JJ cord-104317-t30dg6oj 65 6 behavioral behavioral JJ cord-104317-t30dg6oj 65 7 adaptation adaptation NN cord-104317-t30dg6oj 65 8 is be VBZ cord-104317-t30dg6oj 65 9 the the DT cord-104317-t30dg6oj 65 10 development development NN cord-104317-t30dg6oj 65 11 of of IN cord-104317-t30dg6oj 65 12 vaccination vaccination NN cord-104317-t30dg6oj 65 13 , , , cord-104317-t30dg6oj 65 14 kick kick NN cord-104317-t30dg6oj 65 15 - - HYPH cord-104317-t30dg6oj 65 16 started start VBN cord-104317-t30dg6oj 65 17 by by IN cord-104317-t30dg6oj 65 18 Edward Edward NNP cord-104317-t30dg6oj 65 19 Jenner Jenner NNP cord-104317-t30dg6oj 65 20 's 's POS cord-104317-t30dg6oj 65 21 famous famous JJ cord-104317-t30dg6oj 65 22 work work NN cord-104317-t30dg6oj 65 23 with with IN cord-104317-t30dg6oj 65 24 cowpox cowpox NN cord-104317-t30dg6oj 65 25 [ [ -LRB- cord-104317-t30dg6oj 65 26 35 35 CD cord-104317-t30dg6oj 65 27 ] ] -RRB- cord-104317-t30dg6oj 65 28 . . . cord-104317-t30dg6oj 66 1 However however RB cord-104317-t30dg6oj 66 2 , , , cord-104317-t30dg6oj 66 3 not not RB cord-104317-t30dg6oj 66 4 all all DT cord-104317-t30dg6oj 66 5 parasitic parasitic JJ cord-104317-t30dg6oj 66 6 viruses virus NNS cord-104317-t30dg6oj 66 7 are be VBP cord-104317-t30dg6oj 66 8 deadly deadly JJ cord-104317-t30dg6oj 66 9 . . . cord-104317-t30dg6oj 67 1 In in IN cord-104317-t30dg6oj 67 2 fact fact NN cord-104317-t30dg6oj 67 3 , , , cord-104317-t30dg6oj 67 4 excessive excessive JJ cord-104317-t30dg6oj 67 5 pathogenicity pathogenicity NN cord-104317-t30dg6oj 67 6 is be VBZ cord-104317-t30dg6oj 67 7 an an DT cord-104317-t30dg6oj 67 8 evolutionarily evolutionarily RB cord-104317-t30dg6oj 67 9 poor poor JJ cord-104317-t30dg6oj 67 10 strategy strategy NN cord-104317-t30dg6oj 67 11 for for IN cord-104317-t30dg6oj 67 12 a a DT cord-104317-t30dg6oj 67 13 virus virus NN cord-104317-t30dg6oj 67 14 ' ' `` cord-104317-t30dg6oj 67 15 survival survival NN cord-104317-t30dg6oj 67 16 unless unless IN cord-104317-t30dg6oj 67 17 balanced balance VBN cord-104317-t30dg6oj 67 18 with with IN cord-104317-t30dg6oj 67 19 a a DT cord-104317-t30dg6oj 67 20 number number NN cord-104317-t30dg6oj 67 21 of of IN cord-104317-t30dg6oj 67 22 other other JJ cord-104317-t30dg6oj 67 23 trade trade NN cord-104317-t30dg6oj 67 24 - - HYPH cord-104317-t30dg6oj 67 25 offs off NNS cord-104317-t30dg6oj 67 26 such such JJ cord-104317-t30dg6oj 67 27 as as IN cord-104317-t30dg6oj 67 28 transmission transmission NN cord-104317-t30dg6oj 67 29 rate rate NN cord-104317-t30dg6oj 67 30 and and CC cord-104317-t30dg6oj 67 31 recovery recovery NN cord-104317-t30dg6oj 67 32 rate rate NN cord-104317-t30dg6oj 67 33 [ [ -LRB- cord-104317-t30dg6oj 67 34 36 36 CD cord-104317-t30dg6oj 67 35 ] ] -RRB- cord-104317-t30dg6oj 67 36 . . . cord-104317-t30dg6oj 68 1 Most Most JJS cord-104317-t30dg6oj 68 2 parasitic parasitic JJ cord-104317-t30dg6oj 68 3 infections infection NNS cord-104317-t30dg6oj 68 4 occur occur VBP cord-104317-t30dg6oj 68 5 horizontally horizontally RB cord-104317-t30dg6oj 68 6 ( ( -LRB- cord-104317-t30dg6oj 68 7 though though IN cord-104317-t30dg6oj 68 8 there there EX cord-104317-t30dg6oj 68 9 are be VBP cord-104317-t30dg6oj 68 10 rare rare JJ cord-104317-t30dg6oj 68 11 exceptions exception NNS cord-104317-t30dg6oj 68 12 [ [ -LRB- cord-104317-t30dg6oj 68 13 37 37 CD cord-104317-t30dg6oj 68 14 ] ] -RRB- cord-104317-t30dg6oj 68 15 ) ) -RRB- cord-104317-t30dg6oj 68 16 and and CC cord-104317-t30dg6oj 68 17 the the DT cord-104317-t30dg6oj 68 18 equilibrium equilibrium NN cord-104317-t30dg6oj 68 19 between between IN cord-104317-t30dg6oj 68 20 pathogenicity pathogenicity NN cord-104317-t30dg6oj 68 21 and and CC cord-104317-t30dg6oj 68 22 other other JJ cord-104317-t30dg6oj 68 23 trade trade NN cord-104317-t30dg6oj 68 24 - - HYPH cord-104317-t30dg6oj 68 25 offs off NNS cord-104317-t30dg6oj 68 26 is be VBZ cord-104317-t30dg6oj 68 27 crucial crucial JJ cord-104317-t30dg6oj 68 28 to to IN cord-104317-t30dg6oj 68 29 ensuring ensure VBG cord-104317-t30dg6oj 68 30 continuation continuation NN cord-104317-t30dg6oj 68 31 of of IN cord-104317-t30dg6oj 68 32 the the DT cord-104317-t30dg6oj 68 33 viral viral JJ cord-104317-t30dg6oj 68 34 lineage lineage NN cord-104317-t30dg6oj 68 35 . . . cord-104317-t30dg6oj 69 1 While while IN cord-104317-t30dg6oj 69 2 parasitic parasitic JJ cord-104317-t30dg6oj 69 3 viruses virus NNS cord-104317-t30dg6oj 69 4 by by IN cord-104317-t30dg6oj 69 5 definition definition NN cord-104317-t30dg6oj 69 6 have have VBP cord-104317-t30dg6oj 69 7 some some DT cord-104317-t30dg6oj 69 8 level level NN cord-104317-t30dg6oj 69 9 of of IN cord-104317-t30dg6oj 69 10 pathogenic pathogenic JJ cord-104317-t30dg6oj 69 11 effect effect NN cord-104317-t30dg6oj 69 12 on on IN cord-104317-t30dg6oj 69 13 their -PRON- PRP$ cord-104317-t30dg6oj 69 14 host host NN cord-104317-t30dg6oj 69 15 , , , cord-104317-t30dg6oj 69 16 it -PRON- PRP cord-104317-t30dg6oj 69 17 is be VBZ cord-104317-t30dg6oj 69 18 not not RB cord-104317-t30dg6oj 69 19 the the DT cord-104317-t30dg6oj 69 20 intent intent NN cord-104317-t30dg6oj 69 21 of of IN cord-104317-t30dg6oj 69 22 the the DT cord-104317-t30dg6oj 69 23 virus virus NN cord-104317-t30dg6oj 69 24 to to TO cord-104317-t30dg6oj 69 25 do do VB cord-104317-t30dg6oj 69 26 so so RB cord-104317-t30dg6oj 69 27 , , , cord-104317-t30dg6oj 69 28 because because IN cord-104317-t30dg6oj 69 29 viruses virus NNS cord-104317-t30dg6oj 69 30 do do VBP cord-104317-t30dg6oj 69 31 n't not RB cord-104317-t30dg6oj 69 32 have have VB cord-104317-t30dg6oj 69 33 intentions intention NNS cord-104317-t30dg6oj 69 34 . . . cord-104317-t30dg6oj 70 1 Viral viral JJ cord-104317-t30dg6oj 70 2 genomes genome NNS cord-104317-t30dg6oj 70 3 ( ( -LRB- cord-104317-t30dg6oj 70 4 particularly particularly RB cord-104317-t30dg6oj 70 5 those those DT cord-104317-t30dg6oj 70 6 of of IN cord-104317-t30dg6oj 70 7 RNA RNA NNP cord-104317-t30dg6oj 70 8 viruses virus NNS cord-104317-t30dg6oj 70 9 ) ) -RRB- cord-104317-t30dg6oj 70 10 exist exist VBP cord-104317-t30dg6oj 70 11 as as IN cord-104317-t30dg6oj 70 12 a a DT cord-104317-t30dg6oj 70 13 pool pool NN cord-104317-t30dg6oj 70 14 of of IN cord-104317-t30dg6oj 70 15 non non JJ cord-104317-t30dg6oj 70 16 - - JJ cord-104317-t30dg6oj 70 17 identical identical JJ cord-104317-t30dg6oj 70 18 , , , cord-104317-t30dg6oj 70 19 related related JJ cord-104317-t30dg6oj 70 20 sequences sequence NNS cord-104317-t30dg6oj 70 21 , , , cord-104317-t30dg6oj 70 22 termed term VBN cord-104317-t30dg6oj 70 23 quasispecies quasispecie NNS cord-104317-t30dg6oj 70 24 , , , cord-104317-t30dg6oj 70 25 and and CC cord-104317-t30dg6oj 70 26 are be VBP cord-104317-t30dg6oj 70 27 constantly constantly RB cord-104317-t30dg6oj 70 28 adapting adapt VBG cord-104317-t30dg6oj 70 29 in in IN cord-104317-t30dg6oj 70 30 response response NN cord-104317-t30dg6oj 70 31 to to IN cord-104317-t30dg6oj 70 32 selective selective JJ cord-104317-t30dg6oj 70 33 pressures pressure NNS cord-104317-t30dg6oj 70 34 [ [ -LRB- cord-104317-t30dg6oj 70 35 38 38 CD cord-104317-t30dg6oj 70 36 ] ] -RRB- cord-104317-t30dg6oj 70 37 . . . cord-104317-t30dg6oj 71 1 In in IN cord-104317-t30dg6oj 71 2 some some DT cord-104317-t30dg6oj 71 3 cases case NNS cord-104317-t30dg6oj 71 4 , , , cord-104317-t30dg6oj 71 5 the the DT cord-104317-t30dg6oj 71 6 virus virus NN cord-104317-t30dg6oj 71 7 ' ' '' cord-104317-t30dg6oj 71 8 environment environment NN cord-104317-t30dg6oj 71 9 can can MD cord-104317-t30dg6oj 71 10 select select VB cord-104317-t30dg6oj 71 11 for for IN cord-104317-t30dg6oj 71 12 changes change NNS cord-104317-t30dg6oj 71 13 that that WDT cord-104317-t30dg6oj 71 14 create create VBP cord-104317-t30dg6oj 71 15 a a DT cord-104317-t30dg6oj 71 16 balance balance NN cord-104317-t30dg6oj 71 17 of of IN cord-104317-t30dg6oj 71 18 the the DT cord-104317-t30dg6oj 71 19 above above RB cord-104317-t30dg6oj 71 20 - - HYPH cord-104317-t30dg6oj 71 21 mentioned mention VBN cord-104317-t30dg6oj 71 22 trade trade NN cord-104317-t30dg6oj 71 23 - - HYPH cord-104317-t30dg6oj 71 24 offs off NNS cord-104317-t30dg6oj 71 25 where where WRB cord-104317-t30dg6oj 71 26 pathogenicity pathogenicity NN cord-104317-t30dg6oj 71 27 may may MD cord-104317-t30dg6oj 71 28 be be VB cord-104317-t30dg6oj 71 29 a a DT cord-104317-t30dg6oj 71 30 successful successful JJ cord-104317-t30dg6oj 71 31 , , , cord-104317-t30dg6oj 71 32 or or CC cord-104317-t30dg6oj 71 33 at at IN cord-104317-t30dg6oj 71 34 least least JJS cord-104317-t30dg6oj 71 35 not not RB cord-104317-t30dg6oj 71 36 detrimental detrimental JJ cord-104317-t30dg6oj 71 37 , , , cord-104317-t30dg6oj 71 38 strategy strategy NN cord-104317-t30dg6oj 71 39 [ [ -LRB- cord-104317-t30dg6oj 71 40 39 39 CD cord-104317-t30dg6oj 71 41 ] ] -RRB- cord-104317-t30dg6oj 71 42 . . . cord-104317-t30dg6oj 72 1 In in IN cord-104317-t30dg6oj 72 2 this this DT cord-104317-t30dg6oj 72 3 light light NN cord-104317-t30dg6oj 72 4 , , , cord-104317-t30dg6oj 72 5 I -PRON- PRP cord-104317-t30dg6oj 72 6 will will MD cord-104317-t30dg6oj 72 7 define define VB cord-104317-t30dg6oj 72 8 types type NNS cord-104317-t30dg6oj 72 9 of of IN cord-104317-t30dg6oj 72 10 parasitic parasitic JJ cord-104317-t30dg6oj 72 11 viruses virus NNS cord-104317-t30dg6oj 72 12 according accord VBG cord-104317-t30dg6oj 72 13 to to IN cord-104317-t30dg6oj 72 14 both both CC cord-104317-t30dg6oj 72 15 their -PRON- PRP$ cord-104317-t30dg6oj 72 16 degree degree NN cord-104317-t30dg6oj 72 17 of of IN cord-104317-t30dg6oj 72 18 pathogenesis pathogenesis NN cord-104317-t30dg6oj 72 19 and and CC cord-104317-t30dg6oj 72 20 the the DT cord-104317-t30dg6oj 72 21 way way NN cord-104317-t30dg6oj 72 22 in in IN cord-104317-t30dg6oj 72 23 which which WDT cord-104317-t30dg6oj 72 24 they -PRON- PRP cord-104317-t30dg6oj 72 25 interact interact VBP cord-104317-t30dg6oj 72 26 with with IN cord-104317-t30dg6oj 72 27 their -PRON- PRP$ cord-104317-t30dg6oj 72 28 host host NN cord-104317-t30dg6oj 72 29 . . . cord-104317-t30dg6oj 73 1 The the DT cord-104317-t30dg6oj 73 2 key key JJ cord-104317-t30dg6oj 73 3 characteristic characteristic NN cord-104317-t30dg6oj 73 4 of of IN cord-104317-t30dg6oj 73 5 pathogenic pathogenic JJ cord-104317-t30dg6oj 73 6 viruses virus NNS cord-104317-t30dg6oj 73 7 is be VBZ cord-104317-t30dg6oj 73 8 that that IN cord-104317-t30dg6oj 73 9 they -PRON- PRP cord-104317-t30dg6oj 73 10 cause cause VBP cord-104317-t30dg6oj 73 11 an an DT cord-104317-t30dg6oj 73 12 acute acute JJ cord-104317-t30dg6oj 73 13 disease disease NN cord-104317-t30dg6oj 73 14 in in IN cord-104317-t30dg6oj 73 15 which which WDT cord-104317-t30dg6oj 73 16 the the DT cord-104317-t30dg6oj 73 17 host host NN cord-104317-t30dg6oj 73 18 either either CC cord-104317-t30dg6oj 73 19 lives live VBZ cord-104317-t30dg6oj 73 20 or or CC cord-104317-t30dg6oj 73 21 dies die VBZ cord-104317-t30dg6oj 73 22 , , , cord-104317-t30dg6oj 73 23 with with IN cord-104317-t30dg6oj 73 24 the the DT cord-104317-t30dg6oj 73 25 virus virus NN cord-104317-t30dg6oj 73 26 simply simply RB cord-104317-t30dg6oj 73 27 using use VBG cord-104317-t30dg6oj 73 28 it -PRON- PRP cord-104317-t30dg6oj 73 29 as as IN cord-104317-t30dg6oj 73 30 a a DT cord-104317-t30dg6oj 73 31 vessel vessel NN cord-104317-t30dg6oj 73 32 to to TO cord-104317-t30dg6oj 73 33 move move VB cord-104317-t30dg6oj 73 34 to to IN cord-104317-t30dg6oj 73 35 the the DT cord-104317-t30dg6oj 73 36 next next JJ cord-104317-t30dg6oj 73 37 host host NN cord-104317-t30dg6oj 73 38 . . . cord-104317-t30dg6oj 74 1 In in IN cord-104317-t30dg6oj 74 2 these these DT cord-104317-t30dg6oj 74 3 interactions interaction NNS cord-104317-t30dg6oj 74 4 , , , cord-104317-t30dg6oj 74 5 hosts host NNS cord-104317-t30dg6oj 74 6 typically typically RB cord-104317-t30dg6oj 74 7 mount mount VBP cord-104317-t30dg6oj 74 8 strong strong JJ cord-104317-t30dg6oj 74 9 immune immune JJ cord-104317-t30dg6oj 74 10 responses response NNS cord-104317-t30dg6oj 74 11 and and CC cord-104317-t30dg6oj 74 12 literally literally RB cord-104317-t30dg6oj 74 13 fight fight VB cord-104317-t30dg6oj 74 14 for for IN cord-104317-t30dg6oj 74 15 their -PRON- PRP$ cord-104317-t30dg6oj 74 16 lives life NNS cord-104317-t30dg6oj 74 17 . . . cord-104317-t30dg6oj 75 1 This this DT cord-104317-t30dg6oj 75 2 is be VBZ cord-104317-t30dg6oj 75 3 not not RB cord-104317-t30dg6oj 75 4 to to TO cord-104317-t30dg6oj 75 5 say say VB cord-104317-t30dg6oj 75 6 that that IN cord-104317-t30dg6oj 75 7 all all DT cord-104317-t30dg6oj 75 8 pathogenic pathogenic JJ cord-104317-t30dg6oj 75 9 infections infection NNS cord-104317-t30dg6oj 75 10 are be VBP cord-104317-t30dg6oj 75 11 deadly deadly JJ cord-104317-t30dg6oj 75 12 or or CC cord-104317-t30dg6oj 75 13 resolved resolve VBN cord-104317-t30dg6oj 75 14 immediately immediately RB cord-104317-t30dg6oj 75 15 , , , cord-104317-t30dg6oj 75 16 since since IN cord-104317-t30dg6oj 75 17 the the DT cord-104317-t30dg6oj 75 18 degree degree NN cord-104317-t30dg6oj 75 19 of of IN cord-104317-t30dg6oj 75 20 pathogenicity pathogenicity NN cord-104317-t30dg6oj 75 21 and and CC cord-104317-t30dg6oj 75 22 time time NN cord-104317-t30dg6oj 75 23 to to IN cord-104317-t30dg6oj 75 24 resolution resolution NN cord-104317-t30dg6oj 75 25 vary vary VBP cord-104317-t30dg6oj 75 26 widely widely RB cord-104317-t30dg6oj 75 27 , , , cord-104317-t30dg6oj 75 28 as as IN cord-104317-t30dg6oj 75 29 will will MD cord-104317-t30dg6oj 75 30 be be VB cord-104317-t30dg6oj 75 31 discussed discuss VBN cord-104317-t30dg6oj 75 32 in in IN cord-104317-t30dg6oj 75 33 following follow VBG cord-104317-t30dg6oj 75 34 sections section NNS cord-104317-t30dg6oj 75 35 . . . cord-104317-t30dg6oj 76 1 Rather rather RB cord-104317-t30dg6oj 76 2 , , , cord-104317-t30dg6oj 76 3 the the DT cord-104317-t30dg6oj 76 4 virus virus NN cord-104317-t30dg6oj 76 5 - - HYPH cord-104317-t30dg6oj 76 6 host host NN cord-104317-t30dg6oj 76 7 interactions interaction NNS cord-104317-t30dg6oj 76 8 classified classify VBN cord-104317-t30dg6oj 76 9 here here RB cord-104317-t30dg6oj 76 10 as as IN cord-104317-t30dg6oj 76 11 " " `` cord-104317-t30dg6oj 76 12 pathogenic pathogenic JJ cord-104317-t30dg6oj 76 13 " " '' cord-104317-t30dg6oj 76 14 represent represent VBP cord-104317-t30dg6oj 76 15 perturbations perturbation NNS cord-104317-t30dg6oj 76 16 of of IN cord-104317-t30dg6oj 76 17 homeostasis homeostasis NN cord-104317-t30dg6oj 76 18 for for IN cord-104317-t30dg6oj 76 19 which which WDT cord-104317-t30dg6oj 76 20 the the DT cord-104317-t30dg6oj 76 21 only only JJ cord-104317-t30dg6oj 76 22 resolution resolution NN cord-104317-t30dg6oj 76 23 is be VBZ cord-104317-t30dg6oj 76 24 that that IN cord-104317-t30dg6oj 76 25 one one CD cord-104317-t30dg6oj 76 26 side side NN cord-104317-t30dg6oj 76 27 must must MD cord-104317-t30dg6oj 76 28 prevail prevail VB cord-104317-t30dg6oj 76 29 . . . cord-104317-t30dg6oj 77 1 Either either CC cord-104317-t30dg6oj 77 2 the the DT cord-104317-t30dg6oj 77 3 host host NN cord-104317-t30dg6oj 77 4 completely completely RB cord-104317-t30dg6oj 77 5 clears clear VBZ cord-104317-t30dg6oj 77 6 its -PRON- PRP$ cord-104317-t30dg6oj 77 7 body body NN cord-104317-t30dg6oj 77 8 of of IN cord-104317-t30dg6oj 77 9 the the DT cord-104317-t30dg6oj 77 10 virus virus NN cord-104317-t30dg6oj 77 11 , , , cord-104317-t30dg6oj 77 12 or or CC cord-104317-t30dg6oj 77 13 it -PRON- PRP cord-104317-t30dg6oj 77 14 succumbs succumb VBZ cord-104317-t30dg6oj 77 15 to to IN cord-104317-t30dg6oj 77 16 infection infection NN cord-104317-t30dg6oj 77 17 . . . cord-104317-t30dg6oj 78 1 While while IN cord-104317-t30dg6oj 78 2 this this DT cord-104317-t30dg6oj 78 3 sounds sound VBZ cord-104317-t30dg6oj 78 4 like like IN cord-104317-t30dg6oj 78 5 a a DT cord-104317-t30dg6oj 78 6 poor poor JJ cord-104317-t30dg6oj 78 7 transmission transmission NN cord-104317-t30dg6oj 78 8 strategy strategy NN cord-104317-t30dg6oj 78 9 , , , cord-104317-t30dg6oj 78 10 history history NN cord-104317-t30dg6oj 78 11 has have VBZ cord-104317-t30dg6oj 78 12 shown show VBN cord-104317-t30dg6oj 78 13 it -PRON- PRP cord-104317-t30dg6oj 78 14 can can MD cord-104317-t30dg6oj 78 15 be be VB cord-104317-t30dg6oj 78 16 quite quite RB cord-104317-t30dg6oj 78 17 effective effective JJ cord-104317-t30dg6oj 78 18 , , , cord-104317-t30dg6oj 78 19 as as RB cord-104317-t30dg6oj 78 20 long long RB cord-104317-t30dg6oj 78 21 as as IN cord-104317-t30dg6oj 78 22 the the DT cord-104317-t30dg6oj 78 23 proper proper JJ cord-104317-t30dg6oj 78 24 trade trade NN cord-104317-t30dg6oj 78 25 - - HYPH cord-104317-t30dg6oj 78 26 offs off NNS cord-104317-t30dg6oj 78 27 are be VBP cord-104317-t30dg6oj 78 28 satisfied satisfied JJ cord-104317-t30dg6oj 78 29 ( ( -LRB- cord-104317-t30dg6oj 78 30 see see VB cord-104317-t30dg6oj 78 31 The the DT cord-104317-t30dg6oj 78 32 Parasitic Parasitic NNP cord-104317-t30dg6oj 78 33 Virome Virome NNP cord-104317-t30dg6oj 78 34 , , , cord-104317-t30dg6oj 78 35 above above RB cord-104317-t30dg6oj 78 36 ) ) -RRB- cord-104317-t30dg6oj 78 37 . . . cord-104317-t30dg6oj 79 1 Influenza influenza NN cord-104317-t30dg6oj 79 2 virus virus NN cord-104317-t30dg6oj 79 3 is be VBZ cord-104317-t30dg6oj 79 4 a a DT cord-104317-t30dg6oj 79 5 prime prime JJ cord-104317-t30dg6oj 79 6 example example NN cord-104317-t30dg6oj 79 7 of of IN cord-104317-t30dg6oj 79 8 the the DT cord-104317-t30dg6oj 79 9 success success NN cord-104317-t30dg6oj 79 10 of of IN cord-104317-t30dg6oj 79 11 a a DT cord-104317-t30dg6oj 79 12 pathogenic pathogenic JJ cord-104317-t30dg6oj 79 13 strategy strategy NN cord-104317-t30dg6oj 79 14 . . . cord-104317-t30dg6oj 80 1 Most Most JJS cord-104317-t30dg6oj 80 2 humans human NNS cord-104317-t30dg6oj 80 3 can can MD cord-104317-t30dg6oj 80 4 expect expect VB cord-104317-t30dg6oj 80 5 to to TO cord-104317-t30dg6oj 80 6 be be VB cord-104317-t30dg6oj 80 7 infected infect VBN cord-104317-t30dg6oj 80 8 with with IN cord-104317-t30dg6oj 80 9 at at RB cord-104317-t30dg6oj 80 10 least least RBS cord-104317-t30dg6oj 80 11 one one CD cord-104317-t30dg6oj 80 12 influenza influenza NN cord-104317-t30dg6oj 80 13 virus virus NN cord-104317-t30dg6oj 80 14 per per IN cord-104317-t30dg6oj 80 15 year year NN cord-104317-t30dg6oj 80 16 , , , cord-104317-t30dg6oj 80 17 and and CC cord-104317-t30dg6oj 80 18 in in IN cord-104317-t30dg6oj 80 19 general general JJ cord-104317-t30dg6oj 80 20 they -PRON- PRP cord-104317-t30dg6oj 80 21 will will MD cord-104317-t30dg6oj 80 22 observe observe VB cord-104317-t30dg6oj 80 23 a a DT cord-104317-t30dg6oj 80 24 fairly fairly RB cord-104317-t30dg6oj 80 25 robust robust JJ cord-104317-t30dg6oj 80 26 set set NN cord-104317-t30dg6oj 80 27 of of IN cord-104317-t30dg6oj 80 28 symptoms symptom NNS cord-104317-t30dg6oj 80 29 including include VBG cord-104317-t30dg6oj 80 30 , , , cord-104317-t30dg6oj 80 31 but but CC cord-104317-t30dg6oj 80 32 not not RB cord-104317-t30dg6oj 80 33 limited limited JJ cord-104317-t30dg6oj 80 34 to to IN cord-104317-t30dg6oj 80 35 , , , cord-104317-t30dg6oj 80 36 fever fever NN cord-104317-t30dg6oj 80 37 , , , cord-104317-t30dg6oj 80 38 chills chill NNS cord-104317-t30dg6oj 80 39 , , , cord-104317-t30dg6oj 80 40 headache headache NN cord-104317-t30dg6oj 80 41 , , , cord-104317-t30dg6oj 80 42 nasal nasal NN cord-104317-t30dg6oj 80 43 congestion congestion NN cord-104317-t30dg6oj 80 44 , , , cord-104317-t30dg6oj 80 45 and and CC cord-104317-t30dg6oj 80 46 coughing cough VBG cord-104317-t30dg6oj 80 47 [ [ -LRB- cord-104317-t30dg6oj 80 48 40 40 CD cord-104317-t30dg6oj 80 49 ] ] -RRB- cord-104317-t30dg6oj 80 50 . . . cord-104317-t30dg6oj 81 1 While while IN cord-104317-t30dg6oj 81 2 infection infection NN cord-104317-t30dg6oj 81 3 can can MD cord-104317-t30dg6oj 81 4 be be VB cord-104317-t30dg6oj 81 5 severe severe JJ cord-104317-t30dg6oj 81 6 and and CC cord-104317-t30dg6oj 81 7 even even RB cord-104317-t30dg6oj 81 8 cause cause VB cord-104317-t30dg6oj 81 9 death death NN cord-104317-t30dg6oj 81 10 , , , cord-104317-t30dg6oj 81 11 this this DT cord-104317-t30dg6oj 81 12 is be VBZ cord-104317-t30dg6oj 81 13 typically typically RB cord-104317-t30dg6oj 81 14 limited limit VBN cord-104317-t30dg6oj 81 15 to to IN cord-104317-t30dg6oj 81 16 hosts host NNS cord-104317-t30dg6oj 81 17 in in IN cord-104317-t30dg6oj 81 18 an an DT cord-104317-t30dg6oj 81 19 immunocompromised immunocompromised JJ cord-104317-t30dg6oj 81 20 state state NN cord-104317-t30dg6oj 81 21 , , , cord-104317-t30dg6oj 81 22 as as IN cord-104317-t30dg6oj 81 23 selective selective JJ cord-104317-t30dg6oj 81 24 pressure pressure NN cord-104317-t30dg6oj 81 25 typically typically RB cord-104317-t30dg6oj 81 26 drives drive VBZ cord-104317-t30dg6oj 81 27 virus virus NN cord-104317-t30dg6oj 81 28 evolution evolution NN cord-104317-t30dg6oj 81 29 to to IN cord-104317-t30dg6oj 81 30 less less JJR cord-104317-t30dg6oj 81 31 virulence virulence NN cord-104317-t30dg6oj 81 32 [ [ -LRB- cord-104317-t30dg6oj 81 33 41 41 CD cord-104317-t30dg6oj 81 34 ] ] -RRB- cord-104317-t30dg6oj 81 35 . . . cord-104317-t30dg6oj 82 1 In in IN cord-104317-t30dg6oj 82 2 general general JJ cord-104317-t30dg6oj 82 3 , , , cord-104317-t30dg6oj 82 4 virus virus NN cord-104317-t30dg6oj 82 5 is be VBZ cord-104317-t30dg6oj 82 6 shed shed VBN cord-104317-t30dg6oj 82 7 one one CD cord-104317-t30dg6oj 82 8 to to TO cord-104317-t30dg6oj 82 9 two two CD cord-104317-t30dg6oj 82 10 days day NNS cord-104317-t30dg6oj 82 11 after after IN cord-104317-t30dg6oj 82 12 infection infection NN cord-104317-t30dg6oj 82 13 , , , cord-104317-t30dg6oj 82 14 with with IN cord-104317-t30dg6oj 82 15 symptoms symptom NNS cord-104317-t30dg6oj 82 16 usually usually RB cord-104317-t30dg6oj 82 17 presenting present VBG cord-104317-t30dg6oj 82 18 one one CD cord-104317-t30dg6oj 82 19 day day NN cord-104317-t30dg6oj 82 20 later later RBR cord-104317-t30dg6oj 82 21 , , , cord-104317-t30dg6oj 82 22 ensuring ensure VBG cord-104317-t30dg6oj 82 23 that that IN cord-104317-t30dg6oj 82 24 a a DT cord-104317-t30dg6oj 82 25 person person NN cord-104317-t30dg6oj 82 26 shedding shed VBG cord-104317-t30dg6oj 82 27 virus virus NN cord-104317-t30dg6oj 82 28 will will MD cord-104317-t30dg6oj 82 29 be be VB cord-104317-t30dg6oj 82 30 out out RB cord-104317-t30dg6oj 82 31 and and CC cord-104317-t30dg6oj 82 32 about about IN cord-104317-t30dg6oj 82 33 among among IN cord-104317-t30dg6oj 82 34 currently currently RB cord-104317-t30dg6oj 82 35 uninfected uninfected JJ cord-104317-t30dg6oj 82 36 individuals individual NNS cord-104317-t30dg6oj 82 37 [ [ -LRB- cord-104317-t30dg6oj 82 38 42 42 CD cord-104317-t30dg6oj 82 39 ] ] -RRB- cord-104317-t30dg6oj 82 40 . . . cord-104317-t30dg6oj 83 1 Severe severe JJ cord-104317-t30dg6oj 83 2 symptoms symptom NNS cord-104317-t30dg6oj 83 3 may may MD cord-104317-t30dg6oj 83 4 be be VB cord-104317-t30dg6oj 83 5 due due JJ cord-104317-t30dg6oj 83 6 to to IN cord-104317-t30dg6oj 83 7 viral viral JJ cord-104317-t30dg6oj 83 8 replication replication NN cord-104317-t30dg6oj 83 9 and and CC cord-104317-t30dg6oj 83 10 destruction destruction NN cord-104317-t30dg6oj 83 11 of of IN cord-104317-t30dg6oj 83 12 tissue tissue NN cord-104317-t30dg6oj 83 13 ; ; : cord-104317-t30dg6oj 83 14 however however RB cord-104317-t30dg6oj 83 15 , , , cord-104317-t30dg6oj 83 16 over over IN cord-104317-t30dg6oj 83 17 - - HYPH cord-104317-t30dg6oj 83 18 reaction reaction NN cord-104317-t30dg6oj 83 19 of of IN cord-104317-t30dg6oj 83 20 the the DT cord-104317-t30dg6oj 83 21 immune immune JJ cord-104317-t30dg6oj 83 22 system system NN cord-104317-t30dg6oj 83 23 is be VBZ cord-104317-t30dg6oj 83 24 often often RB cord-104317-t30dg6oj 83 25 the the DT cord-104317-t30dg6oj 83 26 cause cause NN cord-104317-t30dg6oj 83 27 [ [ -LRB- cord-104317-t30dg6oj 83 28 41 41 CD cord-104317-t30dg6oj 83 29 ] ] -RRB- cord-104317-t30dg6oj 83 30 . . . cord-104317-t30dg6oj 84 1 This this DT cord-104317-t30dg6oj 84 2 is be VBZ cord-104317-t30dg6oj 84 3 exemplified exemplify VBN cord-104317-t30dg6oj 84 4 by by IN cord-104317-t30dg6oj 84 5 secondary secondary JJ cord-104317-t30dg6oj 84 6 bacterial bacterial JJ cord-104317-t30dg6oj 84 7 pneumonia pneumonia NN cord-104317-t30dg6oj 84 8 where where WRB cord-104317-t30dg6oj 84 9 blooms bloom NNS cord-104317-t30dg6oj 84 10 of of IN cord-104317-t30dg6oj 84 11 pathogenic pathogenic JJ cord-104317-t30dg6oj 84 12 and/or and/or CC cord-104317-t30dg6oj 84 13 commensal commensal JJ cord-104317-t30dg6oj 84 14 bacteria bacteria NNS cord-104317-t30dg6oj 84 15 can can MD cord-104317-t30dg6oj 84 16 result result VB cord-104317-t30dg6oj 84 17 in in IN cord-104317-t30dg6oj 84 18 severe severe JJ cord-104317-t30dg6oj 84 19 disease disease NN cord-104317-t30dg6oj 84 20 or or CC cord-104317-t30dg6oj 84 21 death death NN cord-104317-t30dg6oj 84 22 [ [ -LRB- cord-104317-t30dg6oj 84 23 38 38 CD cord-104317-t30dg6oj 84 24 ] ] -RRB- cord-104317-t30dg6oj 84 25 [ [ -LRB- cord-104317-t30dg6oj 84 26 39 39 CD cord-104317-t30dg6oj 84 27 ] ] -RRB- cord-104317-t30dg6oj 84 28 [ [ -LRB- cord-104317-t30dg6oj 84 29 40 40 CD cord-104317-t30dg6oj 84 30 ] ] -RRB- cord-104317-t30dg6oj 84 31 [ [ -LRB- cord-104317-t30dg6oj 84 32 41 41 CD cord-104317-t30dg6oj 84 33 ] ] -RRB- cord-104317-t30dg6oj 84 34 . . . cord-104317-t30dg6oj 85 1 However however RB cord-104317-t30dg6oj 85 2 , , , cord-104317-t30dg6oj 85 3 by by IN cord-104317-t30dg6oj 85 4 the the DT cord-104317-t30dg6oj 85 5 time time NN cord-104317-t30dg6oj 85 6 a a DT cord-104317-t30dg6oj 85 7 person person NN cord-104317-t30dg6oj 85 8 has have VBZ cord-104317-t30dg6oj 85 9 become become VBN cord-104317-t30dg6oj 85 10 ill ill JJ cord-104317-t30dg6oj 85 11 , , , cord-104317-t30dg6oj 85 12 they -PRON- PRP cord-104317-t30dg6oj 85 13 have have VBP cord-104317-t30dg6oj 85 14 likely likely RB cord-104317-t30dg6oj 85 15 spread spread VB cord-104317-t30dg6oj 85 16 the the DT cord-104317-t30dg6oj 85 17 virus virus NN cord-104317-t30dg6oj 85 18 by by IN cord-104317-t30dg6oj 85 19 direct direct JJ cord-104317-t30dg6oj 85 20 contact contact NN cord-104317-t30dg6oj 85 21 with with IN cord-104317-t30dg6oj 85 22 an an DT cord-104317-t30dg6oj 85 23 uninfected uninfected JJ cord-104317-t30dg6oj 85 24 individual individual NN cord-104317-t30dg6oj 85 25 , , , cord-104317-t30dg6oj 85 26 contaminated contaminated JJ cord-104317-t30dg6oj 85 27 fomites fomite NNS cord-104317-t30dg6oj 85 28 , , , cord-104317-t30dg6oj 85 29 or or CC cord-104317-t30dg6oj 85 30 aerosolized aerosolize VBN cord-104317-t30dg6oj 85 31 respiratory respiratory JJ cord-104317-t30dg6oj 85 32 droplets droplet NNS cord-104317-t30dg6oj 85 33 [ [ -LRB- cord-104317-t30dg6oj 85 34 46 46 CD cord-104317-t30dg6oj 85 35 ] ] -RRB- cord-104317-t30dg6oj 85 36 . . . cord-104317-t30dg6oj 86 1 The the DT cord-104317-t30dg6oj 86 2 fact fact NN cord-104317-t30dg6oj 86 3 that that IN cord-104317-t30dg6oj 86 4 many many JJ cord-104317-t30dg6oj 86 5 pathogenic pathogenic JJ cord-104317-t30dg6oj 86 6 viruses virus NNS cord-104317-t30dg6oj 86 7 have have VBP cord-104317-t30dg6oj 86 8 circulated circulate VBN cord-104317-t30dg6oj 86 9 in in IN cord-104317-t30dg6oj 86 10 humans human NNS cord-104317-t30dg6oj 86 11 for for IN cord-104317-t30dg6oj 86 12 hundreds hundred NNS cord-104317-t30dg6oj 86 13 to to IN cord-104317-t30dg6oj 86 14 thousands thousand NNS cord-104317-t30dg6oj 86 15 of of IN cord-104317-t30dg6oj 86 16 years year NNS cord-104317-t30dg6oj 86 17 , , , cord-104317-t30dg6oj 86 18 despite despite IN cord-104317-t30dg6oj 86 19 our -PRON- PRP$ cord-104317-t30dg6oj 86 20 best good JJS cord-104317-t30dg6oj 86 21 efforts effort NNS cord-104317-t30dg6oj 86 22 to to TO cord-104317-t30dg6oj 86 23 eliminate eliminate VB cord-104317-t30dg6oj 86 24 them -PRON- PRP cord-104317-t30dg6oj 86 25 , , , cord-104317-t30dg6oj 86 26 speaks speak VBZ cord-104317-t30dg6oj 86 27 to to IN cord-104317-t30dg6oj 86 28 their -PRON- PRP$ cord-104317-t30dg6oj 86 29 success success NN cord-104317-t30dg6oj 86 30 . . . cord-104317-t30dg6oj 87 1 As as IN cord-104317-t30dg6oj 87 2 far far RB cord-104317-t30dg6oj 87 3 back back RB cord-104317-t30dg6oj 87 4 as as IN cord-104317-t30dg6oj 87 5 the the DT cord-104317-t30dg6oj 87 6 16th-11th 16th-11th CD cord-104317-t30dg6oj 87 7 centuries century NNS cord-104317-t30dg6oj 87 8 B.C. B.C. NNP cord-104317-t30dg6oj 87 9 , , , cord-104317-t30dg6oj 87 10 there there EX cord-104317-t30dg6oj 87 11 is be VBZ cord-104317-t30dg6oj 87 12 evidence evidence NN cord-104317-t30dg6oj 87 13 of of IN cord-104317-t30dg6oj 87 14 poliomyelitis poliomyelitis NN cord-104317-t30dg6oj 87 15 caused cause VBN cord-104317-t30dg6oj 87 16 by by IN cord-104317-t30dg6oj 87 17 poliovirus poliovirus NN cord-104317-t30dg6oj 87 18 in in IN cord-104317-t30dg6oj 87 19 Egypt Egypt NNP cord-104317-t30dg6oj 87 20 [ [ -LRB- cord-104317-t30dg6oj 87 21 47 47 CD cord-104317-t30dg6oj 87 22 ] ] -RRB- cord-104317-t30dg6oj 87 23 . . . cord-104317-t30dg6oj 88 1 A a DT cord-104317-t30dg6oj 88 2 more more RBR cord-104317-t30dg6oj 88 3 recent recent JJ cord-104317-t30dg6oj 88 4 example example NN cord-104317-t30dg6oj 88 5 is be VBZ cord-104317-t30dg6oj 88 6 measles measles NN cord-104317-t30dg6oj 88 7 virus virus NN cord-104317-t30dg6oj 88 8 , , , cord-104317-t30dg6oj 88 9 which which WDT cord-104317-t30dg6oj 88 10 appears appear VBZ cord-104317-t30dg6oj 88 11 to to TO cord-104317-t30dg6oj 88 12 have have VB cord-104317-t30dg6oj 88 13 diverged diverge VBN cord-104317-t30dg6oj 88 14 from from IN cord-104317-t30dg6oj 88 15 rinderpest rinderpest NN cord-104317-t30dg6oj 88 16 sometime sometime RB cord-104317-t30dg6oj 88 17 in in IN cord-104317-t30dg6oj 88 18 the the DT cord-104317-t30dg6oj 88 19 11th 11th JJ cord-104317-t30dg6oj 88 20 or or CC cord-104317-t30dg6oj 88 21 12th 12th JJ cord-104317-t30dg6oj 88 22 century century NN cord-104317-t30dg6oj 88 23 B.C. B.C. NNP cord-104317-t30dg6oj 89 1 [ [ -LRB- cord-104317-t30dg6oj 89 2 48 48 CD cord-104317-t30dg6oj 89 3 ] ] -RRB- cord-104317-t30dg6oj 89 4 . . . cord-104317-t30dg6oj 90 1 The the DT cord-104317-t30dg6oj 90 2 long long JJ cord-104317-t30dg6oj 90 3 histories history NNS cord-104317-t30dg6oj 90 4 of of IN cord-104317-t30dg6oj 90 5 human human JJ cord-104317-t30dg6oj 90 6 disease disease NN cord-104317-t30dg6oj 90 7 caused cause VBN cord-104317-t30dg6oj 90 8 by by IN cord-104317-t30dg6oj 90 9 these these DT cord-104317-t30dg6oj 90 10 and and CC cord-104317-t30dg6oj 90 11 other other JJ cord-104317-t30dg6oj 90 12 pathogenic pathogenic JJ cord-104317-t30dg6oj 90 13 viruses virus NNS cord-104317-t30dg6oj 90 14 made make VBD cord-104317-t30dg6oj 90 15 them -PRON- PRP cord-104317-t30dg6oj 90 16 low low JJ cord-104317-t30dg6oj 90 17 hanging hang VBG cord-104317-t30dg6oj 90 18 fruits fruit NNS cord-104317-t30dg6oj 90 19 for for IN cord-104317-t30dg6oj 90 20 study study NN cord-104317-t30dg6oj 90 21 in in IN cord-104317-t30dg6oj 90 22 the the DT cord-104317-t30dg6oj 90 23 new new JJ cord-104317-t30dg6oj 90 24 field field NN cord-104317-t30dg6oj 90 25 of of IN cord-104317-t30dg6oj 90 26 microbiology microbiology NN cord-104317-t30dg6oj 90 27 in in IN cord-104317-t30dg6oj 90 28 the the DT cord-104317-t30dg6oj 90 29 early early JJ cord-104317-t30dg6oj 90 30 19th 19th JJ cord-104317-t30dg6oj 90 31 century century NN cord-104317-t30dg6oj 90 32 [ [ -LRB- cord-104317-t30dg6oj 90 33 47 47 CD cord-104317-t30dg6oj 90 34 ] ] -RRB- cord-104317-t30dg6oj 90 35 . . . cord-104317-t30dg6oj 91 1 This this DT cord-104317-t30dg6oj 91 2 can can MD cord-104317-t30dg6oj 91 3 explain explain VB cord-104317-t30dg6oj 91 4 much much JJ cord-104317-t30dg6oj 91 5 of of IN cord-104317-t30dg6oj 91 6 the the DT cord-104317-t30dg6oj 91 7 bias bias NN cord-104317-t30dg6oj 91 8 of of IN cord-104317-t30dg6oj 91 9 current current JJ cord-104317-t30dg6oj 91 10 knowledge knowledge NN cord-104317-t30dg6oj 91 11 toward toward IN cord-104317-t30dg6oj 91 12 pathogenic pathogenic JJ cord-104317-t30dg6oj 91 13 viruses virus NNS cord-104317-t30dg6oj 91 14 . . . cord-104317-t30dg6oj 92 1 While while IN cord-104317-t30dg6oj 92 2 it -PRON- PRP cord-104317-t30dg6oj 92 3 can can MD cord-104317-t30dg6oj 92 4 be be VB cord-104317-t30dg6oj 92 5 argued argue VBN cord-104317-t30dg6oj 92 6 that that IN cord-104317-t30dg6oj 92 7 in in IN cord-104317-t30dg6oj 92 8 the the DT cord-104317-t30dg6oj 92 9 majority majority NN cord-104317-t30dg6oj 92 10 of of IN cord-104317-t30dg6oj 92 11 human human JJ cord-104317-t30dg6oj 92 12 history history NN cord-104317-t30dg6oj 92 13 these these DT cord-104317-t30dg6oj 92 14 viruses virus NNS cord-104317-t30dg6oj 92 15 were be VBD cord-104317-t30dg6oj 92 16 the the DT cord-104317-t30dg6oj 92 17 most most RBS cord-104317-t30dg6oj 92 18 formative formative JJ cord-104317-t30dg6oj 92 19 in in IN cord-104317-t30dg6oj 92 20 terms term NNS cord-104317-t30dg6oj 92 21 of of IN cord-104317-t30dg6oj 92 22 social social JJ cord-104317-t30dg6oj 92 23 , , , cord-104317-t30dg6oj 92 24 cultural cultural JJ cord-104317-t30dg6oj 92 25 , , , cord-104317-t30dg6oj 92 26 and and CC cord-104317-t30dg6oj 92 27 behavioral behavioral JJ cord-104317-t30dg6oj 92 28 characteristics characteristic NNS cord-104317-t30dg6oj 92 29 of of IN cord-104317-t30dg6oj 92 30 humans human NNS cord-104317-t30dg6oj 92 31 , , , cord-104317-t30dg6oj 92 32 it -PRON- PRP cord-104317-t30dg6oj 92 33 can can MD cord-104317-t30dg6oj 92 34 not not RB cord-104317-t30dg6oj 92 35 be be VB cord-104317-t30dg6oj 92 36 overlooked overlook VBN cord-104317-t30dg6oj 92 37 that that IN cord-104317-t30dg6oj 92 38 this this DT cord-104317-t30dg6oj 92 39 point point NN cord-104317-t30dg6oj 92 40 may may MD cord-104317-t30dg6oj 92 41 also also RB cord-104317-t30dg6oj 92 42 be be VB cord-104317-t30dg6oj 92 43 similarly similarly RB cord-104317-t30dg6oj 92 44 biased biased JJ cord-104317-t30dg6oj 92 45 . . . cord-104317-t30dg6oj 93 1 The the DT cord-104317-t30dg6oj 93 2 notion notion NN cord-104317-t30dg6oj 93 3 that that IN cord-104317-t30dg6oj 93 4 some some DT cord-104317-t30dg6oj 93 5 viruses virus NNS cord-104317-t30dg6oj 93 6 could could MD cord-104317-t30dg6oj 93 7 live live VB cord-104317-t30dg6oj 93 8 in in IN cord-104317-t30dg6oj 93 9 relative relative JJ cord-104317-t30dg6oj 93 10 homeostasis homeostasis NN cord-104317-t30dg6oj 93 11 with with IN cord-104317-t30dg6oj 93 12 the the DT cord-104317-t30dg6oj 93 13 organisms organism NNS cord-104317-t30dg6oj 93 14 they -PRON- PRP cord-104317-t30dg6oj 93 15 infect infect VBP cord-104317-t30dg6oj 93 16 is be VBZ cord-104317-t30dg6oj 93 17 very very RB cord-104317-t30dg6oj 93 18 recent recent JJ cord-104317-t30dg6oj 93 19 , , , cord-104317-t30dg6oj 93 20 and and CC cord-104317-t30dg6oj 93 21 such such JJ cord-104317-t30dg6oj 93 22 interactions interaction NNS cord-104317-t30dg6oj 93 23 may may MD cord-104317-t30dg6oj 93 24 prove prove VB cord-104317-t30dg6oj 93 25 to to TO cord-104317-t30dg6oj 93 26 be be VB cord-104317-t30dg6oj 93 27 a a DT cord-104317-t30dg6oj 93 28 renaissance renaissance NN cord-104317-t30dg6oj 93 29 in in IN cord-104317-t30dg6oj 93 30 the the DT cord-104317-t30dg6oj 93 31 thinking thinking NN cord-104317-t30dg6oj 93 32 of of IN cord-104317-t30dg6oj 93 33 the the DT cord-104317-t30dg6oj 93 34 importance importance NN cord-104317-t30dg6oj 93 35 of of IN cord-104317-t30dg6oj 93 36 different different JJ cord-104317-t30dg6oj 93 37 portions portion NNS cord-104317-t30dg6oj 93 38 of of IN cord-104317-t30dg6oj 93 39 the the DT cord-104317-t30dg6oj 93 40 virome virome NN cord-104317-t30dg6oj 93 41 . . . cord-104317-t30dg6oj 94 1 In in IN cord-104317-t30dg6oj 94 2 fact fact NN cord-104317-t30dg6oj 94 3 , , , cord-104317-t30dg6oj 94 4 some some DT cord-104317-t30dg6oj 94 5 of of IN cord-104317-t30dg6oj 94 6 the the DT cord-104317-t30dg6oj 94 7 most most RBS cord-104317-t30dg6oj 94 8 clinically clinically RB cord-104317-t30dg6oj 94 9 important important JJ cord-104317-t30dg6oj 94 10 viruses virus NNS cord-104317-t30dg6oj 94 11 of of IN cord-104317-t30dg6oj 94 12 the the DT cord-104317-t30dg6oj 94 13 last last JJ cord-104317-t30dg6oj 94 14 century century NN cord-104317-t30dg6oj 94 15 were be VBD cord-104317-t30dg6oj 94 16 not not RB cord-104317-t30dg6oj 94 17 classically classically RB cord-104317-t30dg6oj 94 18 pathogenic pathogenic JJ cord-104317-t30dg6oj 94 19 , , , cord-104317-t30dg6oj 94 20 but but CC cord-104317-t30dg6oj 94 21 rather rather RB cord-104317-t30dg6oj 94 22 , , , cord-104317-t30dg6oj 94 23 persist persist VBP cord-104317-t30dg6oj 94 24 within within IN cord-104317-t30dg6oj 94 25 the the DT cord-104317-t30dg6oj 94 26 host host NN cord-104317-t30dg6oj 94 27 in in IN cord-104317-t30dg6oj 94 28 relative relative JJ cord-104317-t30dg6oj 94 29 silence silence NN cord-104317-t30dg6oj 94 30 for for IN cord-104317-t30dg6oj 94 31 long long JJ cord-104317-t30dg6oj 94 32 periods period NNS cord-104317-t30dg6oj 94 33 of of IN cord-104317-t30dg6oj 94 34 time time NN cord-104317-t30dg6oj 94 35 . . . cord-104317-t30dg6oj 95 1 The the DT cord-104317-t30dg6oj 95 2 characteristic characteristic JJ cord-104317-t30dg6oj 95 3 strategy strategy NN cord-104317-t30dg6oj 95 4 of of IN cord-104317-t30dg6oj 95 5 persistent persistent JJ cord-104317-t30dg6oj 95 6 viruses virus NNS cord-104317-t30dg6oj 95 7 is be VBZ cord-104317-t30dg6oj 95 8 one one CD cord-104317-t30dg6oj 95 9 of of IN cord-104317-t30dg6oj 95 10 immune immune JJ cord-104317-t30dg6oj 95 11 evasion evasion NN cord-104317-t30dg6oj 95 12 and and CC cord-104317-t30dg6oj 95 13 long long JJ cord-104317-t30dg6oj 95 14 term term NN cord-104317-t30dg6oj 95 15 interaction interaction NN cord-104317-t30dg6oj 95 16 with with IN cord-104317-t30dg6oj 95 17 the the DT cord-104317-t30dg6oj 95 18 host host NN cord-104317-t30dg6oj 95 19 . . . cord-104317-t30dg6oj 96 1 Typically typically RB cord-104317-t30dg6oj 96 2 , , , cord-104317-t30dg6oj 96 3 these these DT cord-104317-t30dg6oj 96 4 viruses virus NNS cord-104317-t30dg6oj 96 5 exhibit exhibit VBP cord-104317-t30dg6oj 96 6 mild mild JJ cord-104317-t30dg6oj 96 7 and and CC cord-104317-t30dg6oj 96 8 short short RB cord-104317-t30dg6oj 96 9 - - HYPH cord-104317-t30dg6oj 96 10 lived live VBN cord-104317-t30dg6oj 96 11 acute acute JJ cord-104317-t30dg6oj 96 12 phase phase NN cord-104317-t30dg6oj 96 13 infections infection NNS cord-104317-t30dg6oj 96 14 followed follow VBN cord-104317-t30dg6oj 96 15 by by IN cord-104317-t30dg6oj 96 16 establishment establishment NN cord-104317-t30dg6oj 96 17 of of IN cord-104317-t30dg6oj 96 18 a a DT cord-104317-t30dg6oj 96 19 long long JJ cord-104317-t30dg6oj 96 20 term term NN cord-104317-t30dg6oj 96 21 niche niche NN cord-104317-t30dg6oj 96 22 within within IN cord-104317-t30dg6oj 96 23 a a DT cord-104317-t30dg6oj 96 24 host host NN cord-104317-t30dg6oj 96 25 . . . cord-104317-t30dg6oj 97 1 In in IN cord-104317-t30dg6oj 97 2 this this DT cord-104317-t30dg6oj 97 3 niche niche NN cord-104317-t30dg6oj 97 4 , , , cord-104317-t30dg6oj 97 5 the the DT cord-104317-t30dg6oj 97 6 virus virus NN cord-104317-t30dg6oj 97 7 may may MD cord-104317-t30dg6oj 97 8 go go VB cord-104317-t30dg6oj 97 9 through through IN cord-104317-t30dg6oj 97 10 stages stage NNS cord-104317-t30dg6oj 97 11 of of IN cord-104317-t30dg6oj 97 12 dormancy dormancy NN cord-104317-t30dg6oj 97 13 and and CC cord-104317-t30dg6oj 97 14 reactivation reactivation NN cord-104317-t30dg6oj 97 15 , , , cord-104317-t30dg6oj 97 16 or or CC cord-104317-t30dg6oj 97 17 slow slow JJ cord-104317-t30dg6oj 97 18 replication replication NN cord-104317-t30dg6oj 97 19 for for IN cord-104317-t30dg6oj 97 20 a a DT cord-104317-t30dg6oj 97 21 long long JJ cord-104317-t30dg6oj 97 22 period period NN cord-104317-t30dg6oj 97 23 of of IN cord-104317-t30dg6oj 97 24 time time NN cord-104317-t30dg6oj 97 25 [ [ -LRB- cord-104317-t30dg6oj 97 26 50 50 CD cord-104317-t30dg6oj 97 27 ] ] -RRB- cord-104317-t30dg6oj 97 28 . . . cord-104317-t30dg6oj 98 1 This this DT cord-104317-t30dg6oj 98 2 ability ability NN cord-104317-t30dg6oj 98 3 to to TO cord-104317-t30dg6oj 98 4 progress progress VB cord-104317-t30dg6oj 98 5 to to IN cord-104317-t30dg6oj 98 6 persistence persistence NN cord-104317-t30dg6oj 98 7 for for IN cord-104317-t30dg6oj 98 8 months month NNS cord-104317-t30dg6oj 98 9 , , , cord-104317-t30dg6oj 98 10 years year NNS cord-104317-t30dg6oj 98 11 , , , cord-104317-t30dg6oj 98 12 or or CC cord-104317-t30dg6oj 98 13 the the DT cord-104317-t30dg6oj 98 14 entire entire JJ cord-104317-t30dg6oj 98 15 life life NN cord-104317-t30dg6oj 98 16 of of IN cord-104317-t30dg6oj 98 17 the the DT cord-104317-t30dg6oj 98 18 host host NN cord-104317-t30dg6oj 98 19 clearly clearly RB cord-104317-t30dg6oj 98 20 delineates delineate VBZ cord-104317-t30dg6oj 98 21 these these DT cord-104317-t30dg6oj 98 22 viruses virus NNS cord-104317-t30dg6oj 98 23 from from IN cord-104317-t30dg6oj 98 24 the the DT cord-104317-t30dg6oj 98 25 pathogenic pathogenic JJ cord-104317-t30dg6oj 98 26 viruses virus NNS cord-104317-t30dg6oj 98 27 [ [ -LRB- cord-104317-t30dg6oj 98 28 51 51 CD cord-104317-t30dg6oj 98 29 ] ] -RRB- cord-104317-t30dg6oj 98 30 . . . cord-104317-t30dg6oj 99 1 These these DT cord-104317-t30dg6oj 99 2 relationships relationship NNS cord-104317-t30dg6oj 99 3 straddle straddle VBP cord-104317-t30dg6oj 99 4 the the DT cord-104317-t30dg6oj 99 5 border border NN cord-104317-t30dg6oj 99 6 somewhere somewhere RB cord-104317-t30dg6oj 99 7 between between IN cord-104317-t30dg6oj 99 8 symbiosis symbiosis NN cord-104317-t30dg6oj 99 9 and and CC cord-104317-t30dg6oj 99 10 pathogenesis pathogenesis NN cord-104317-t30dg6oj 99 11 , , , cord-104317-t30dg6oj 99 12 traditionally traditionally RB cord-104317-t30dg6oj 99 13 making make VBG cord-104317-t30dg6oj 99 14 it -PRON- PRP cord-104317-t30dg6oj 99 15 difficult difficult JJ cord-104317-t30dg6oj 99 16 to to TO cord-104317-t30dg6oj 99 17 classify classify VB cord-104317-t30dg6oj 99 18 them -PRON- PRP cord-104317-t30dg6oj 99 19 . . . cord-104317-t30dg6oj 100 1 In in IN cord-104317-t30dg6oj 100 2 this this DT cord-104317-t30dg6oj 100 3 context context NN cord-104317-t30dg6oj 100 4 , , , cord-104317-t30dg6oj 100 5 I -PRON- PRP cord-104317-t30dg6oj 100 6 will will MD cord-104317-t30dg6oj 100 7 typify typify VB cord-104317-t30dg6oj 100 8 long long JJ cord-104317-t30dg6oj 100 9 - - HYPH cord-104317-t30dg6oj 100 10 term term NN cord-104317-t30dg6oj 100 11 infections infection NNS cord-104317-t30dg6oj 100 12 with with IN cord-104317-t30dg6oj 100 13 well well RB cord-104317-t30dg6oj 100 14 - - HYPH cord-104317-t30dg6oj 100 15 described describe VBN cord-104317-t30dg6oj 100 16 detriment detriment NN cord-104317-t30dg6oj 100 17 to to IN cord-104317-t30dg6oj 100 18 the the DT cord-104317-t30dg6oj 100 19 host host NN cord-104317-t30dg6oj 100 20 as as IN cord-104317-t30dg6oj 100 21 persistent persistent JJ cord-104317-t30dg6oj 100 22 , , , cord-104317-t30dg6oj 100 23 and and CC cord-104317-t30dg6oj 100 24 other other JJ cord-104317-t30dg6oj 100 25 longterm longterm JJ cord-104317-t30dg6oj 100 26 interactions interaction NNS cord-104317-t30dg6oj 100 27 as as IN cord-104317-t30dg6oj 100 28 either either CC cord-104317-t30dg6oj 100 29 commensal commensal JJ cord-104317-t30dg6oj 100 30 or or CC cord-104317-t30dg6oj 100 31 mutualistic mutualistic JJ cord-104317-t30dg6oj 100 32 ( ( -LRB- cord-104317-t30dg6oj 100 33 see see VB cord-104317-t30dg6oj 100 34 respective respective JJ cord-104317-t30dg6oj 100 35 sections section NNS cord-104317-t30dg6oj 100 36 , , , cord-104317-t30dg6oj 100 37 below below RB cord-104317-t30dg6oj 100 38 ) ) -RRB- cord-104317-t30dg6oj 100 39 . . . cord-104317-t30dg6oj 101 1 While while IN cord-104317-t30dg6oj 101 2 the the DT cord-104317-t30dg6oj 101 3 virus virus NN cord-104317-t30dg6oj 101 4 has have VBZ cord-104317-t30dg6oj 101 5 a a DT cord-104317-t30dg6oj 101 6 safe safe JJ cord-104317-t30dg6oj 101 7 home home NN cord-104317-t30dg6oj 101 8 during during IN cord-104317-t30dg6oj 101 9 persistence persistence NN cord-104317-t30dg6oj 101 10 , , , cord-104317-t30dg6oj 101 11 the the DT cord-104317-t30dg6oj 101 12 question question NN cord-104317-t30dg6oj 101 13 arises arise VBZ cord-104317-t30dg6oj 101 14 that that IN cord-104317-t30dg6oj 101 15 if if IN cord-104317-t30dg6oj 101 16 a a DT cord-104317-t30dg6oj 101 17 virus virus NN cord-104317-t30dg6oj 101 18 is be VBZ cord-104317-t30dg6oj 101 19 not not RB cord-104317-t30dg6oj 101 20 replicating replicate VBG cord-104317-t30dg6oj 101 21 , , , cord-104317-t30dg6oj 101 22 or or CC cord-104317-t30dg6oj 101 23 is be VBZ cord-104317-t30dg6oj 101 24 present present JJ cord-104317-t30dg6oj 101 25 at at IN cord-104317-t30dg6oj 101 26 very very RB cord-104317-t30dg6oj 101 27 low low JJ cord-104317-t30dg6oj 101 28 levels level NNS cord-104317-t30dg6oj 101 29 , , , cord-104317-t30dg6oj 101 30 how how WRB cord-104317-t30dg6oj 101 31 is be VBZ cord-104317-t30dg6oj 101 32 it -PRON- PRP cord-104317-t30dg6oj 101 33 transmitted transmit VBN cord-104317-t30dg6oj 101 34 to to IN cord-104317-t30dg6oj 101 35 the the DT cord-104317-t30dg6oj 101 36 next next JJ cord-104317-t30dg6oj 101 37 host host NN cord-104317-t30dg6oj 101 38 ? ? . cord-104317-t30dg6oj 102 1 The the DT cord-104317-t30dg6oj 102 2 answer answer NN cord-104317-t30dg6oj 102 3 lies lie VBZ cord-104317-t30dg6oj 102 4 in in IN cord-104317-t30dg6oj 102 5 the the DT cord-104317-t30dg6oj 102 6 spread spread NN cord-104317-t30dg6oj 102 7 of of IN cord-104317-t30dg6oj 102 8 virus virus NN cord-104317-t30dg6oj 102 9 via via IN cord-104317-t30dg6oj 102 10 close close JJ cord-104317-t30dg6oj 102 11 intrahost intrahost NN cord-104317-t30dg6oj 102 12 interactions interaction NNS cord-104317-t30dg6oj 102 13 that that WDT cord-104317-t30dg6oj 102 14 may may MD cord-104317-t30dg6oj 102 15 occur occur VB cord-104317-t30dg6oj 102 16 many many JJ cord-104317-t30dg6oj 102 17 times time NNS cord-104317-t30dg6oj 102 18 during during IN cord-104317-t30dg6oj 102 19 the the DT cord-104317-t30dg6oj 102 20 host host NN cord-104317-t30dg6oj 102 21 's 's POS cord-104317-t30dg6oj 102 22 life life NN cord-104317-t30dg6oj 102 23 . . . cord-104317-t30dg6oj 103 1 The the DT cord-104317-t30dg6oj 103 2 most most RBS cord-104317-t30dg6oj 103 3 conventional conventional JJ cord-104317-t30dg6oj 103 4 method method NN cord-104317-t30dg6oj 103 5 by by IN cord-104317-t30dg6oj 103 6 which which WDT cord-104317-t30dg6oj 103 7 persistent persistent JJ cord-104317-t30dg6oj 103 8 viruses virus NNS cord-104317-t30dg6oj 103 9 are be VBP cord-104317-t30dg6oj 103 10 transmitted transmit VBN cord-104317-t30dg6oj 103 11 is be VBZ cord-104317-t30dg6oj 103 12 contact contact NN cord-104317-t30dg6oj 103 13 between between IN cord-104317-t30dg6oj 103 14 mucous mucous JJ cord-104317-t30dg6oj 103 15 membranes membrane NNS cord-104317-t30dg6oj 103 16 . . . cord-104317-t30dg6oj 104 1 This this DT cord-104317-t30dg6oj 104 2 includes include VBZ cord-104317-t30dg6oj 104 3 kissing kissing NN cord-104317-t30dg6oj 104 4 and and CC cord-104317-t30dg6oj 104 5 sexual sexual JJ cord-104317-t30dg6oj 104 6 intercourse intercourse NN cord-104317-t30dg6oj 104 7 , , , cord-104317-t30dg6oj 104 8 but but CC cord-104317-t30dg6oj 104 9 can can MD cord-104317-t30dg6oj 104 10 also also RB cord-104317-t30dg6oj 104 11 include include VB cord-104317-t30dg6oj 104 12 transmission transmission NN cord-104317-t30dg6oj 104 13 vertically vertically RB cord-104317-t30dg6oj 104 14 from from IN cord-104317-t30dg6oj 104 15 mother mother NN cord-104317-t30dg6oj 104 16 to to IN cord-104317-t30dg6oj 104 17 child child NN cord-104317-t30dg6oj 104 18 , , , cord-104317-t30dg6oj 104 19 in in IN cord-104317-t30dg6oj 104 20 rare rare JJ cord-104317-t30dg6oj 104 21 cases case NNS cord-104317-t30dg6oj 104 22 [ [ -LRB- cord-104317-t30dg6oj 104 23 37 37 CD cord-104317-t30dg6oj 104 24 ] ] -RRB- cord-104317-t30dg6oj 104 25 . . . cord-104317-t30dg6oj 105 1 The the DT cord-104317-t30dg6oj 105 2 prototypical prototypical JJ cord-104317-t30dg6oj 105 3 example example NN cord-104317-t30dg6oj 105 4 is be VBZ cord-104317-t30dg6oj 105 5 herpes herpes NNP cord-104317-t30dg6oj 105 6 simplex simplex NNP cord-104317-t30dg6oj 105 7 virus virus NN cord-104317-t30dg6oj 105 8 1 1 CD cord-104317-t30dg6oj 105 9 ( ( -LRB- cord-104317-t30dg6oj 105 10 HSV-1 HSV-1 NNP cord-104317-t30dg6oj 105 11 ) ) -RRB- cord-104317-t30dg6oj 105 12 which which WDT cord-104317-t30dg6oj 105 13 , , , cord-104317-t30dg6oj 105 14 after after IN cord-104317-t30dg6oj 105 15 an an DT cord-104317-t30dg6oj 105 16 initial initial JJ cord-104317-t30dg6oj 105 17 acute acute JJ cord-104317-t30dg6oj 105 18 or or CC cord-104317-t30dg6oj 105 19 subclinical subclinical JJ cord-104317-t30dg6oj 105 20 infection infection NN cord-104317-t30dg6oj 105 21 , , , cord-104317-t30dg6oj 105 22 moves move VBZ cord-104317-t30dg6oj 105 23 into into IN cord-104317-t30dg6oj 105 24 a a DT cord-104317-t30dg6oj 105 25 sensory sensory JJ cord-104317-t30dg6oj 105 26 neuron neuron NN cord-104317-t30dg6oj 105 27 and and CC cord-104317-t30dg6oj 105 28 enters enter VBZ cord-104317-t30dg6oj 105 29 a a DT cord-104317-t30dg6oj 105 30 period period NN cord-104317-t30dg6oj 105 31 of of IN cord-104317-t30dg6oj 105 32 latency latency NN cord-104317-t30dg6oj 105 33 [ [ -LRB- cord-104317-t30dg6oj 105 34 52 52 CD cord-104317-t30dg6oj 105 35 ] ] -RRB- cord-104317-t30dg6oj 105 36 . . . cord-104317-t30dg6oj 106 1 Later later RB cord-104317-t30dg6oj 106 2 in in IN cord-104317-t30dg6oj 106 3 life life NN cord-104317-t30dg6oj 106 4 the the DT cord-104317-t30dg6oj 106 5 virus virus NN cord-104317-t30dg6oj 106 6 can can MD cord-104317-t30dg6oj 106 7 break break VB cord-104317-t30dg6oj 106 8 latency latency NN cord-104317-t30dg6oj 106 9 , , , cord-104317-t30dg6oj 106 10 move move VB cord-104317-t30dg6oj 106 11 down down IN cord-104317-t30dg6oj 106 12 the the DT cord-104317-t30dg6oj 106 13 neuron neuron NN cord-104317-t30dg6oj 106 14 to to IN cord-104317-t30dg6oj 106 15 the the DT cord-104317-t30dg6oj 106 16 skin skin NN cord-104317-t30dg6oj 106 17 , , , cord-104317-t30dg6oj 106 18 and and CC cord-104317-t30dg6oj 106 19 begin begin VB cord-104317-t30dg6oj 106 20 to to TO cord-104317-t30dg6oj 106 21 replicate replicate VB cord-104317-t30dg6oj 106 22 , , , cord-104317-t30dg6oj 106 23 the the DT cord-104317-t30dg6oj 106 24 prototypical prototypical JJ cord-104317-t30dg6oj 106 25 presentation presentation NN cord-104317-t30dg6oj 106 26 of of IN cord-104317-t30dg6oj 106 27 which which WDT cord-104317-t30dg6oj 106 28 is be VBZ cord-104317-t30dg6oj 106 29 a a DT cord-104317-t30dg6oj 106 30 cold cold JJ cord-104317-t30dg6oj 106 31 sore sore NN cord-104317-t30dg6oj 106 32 . . . cord-104317-t30dg6oj 107 1 These these DT cord-104317-t30dg6oj 107 2 lesions lesion NNS cord-104317-t30dg6oj 107 3 release release VBP cord-104317-t30dg6oj 107 4 infectious infectious JJ cord-104317-t30dg6oj 107 5 virus virus NN cord-104317-t30dg6oj 107 6 that that WDT cord-104317-t30dg6oj 107 7 can can MD cord-104317-t30dg6oj 107 8 be be VB cord-104317-t30dg6oj 107 9 transmitted transmit VBN cord-104317-t30dg6oj 107 10 to to IN cord-104317-t30dg6oj 107 11 a a DT cord-104317-t30dg6oj 107 12 new new JJ cord-104317-t30dg6oj 107 13 host host NN cord-104317-t30dg6oj 107 14 . . . cord-104317-t30dg6oj 108 1 After after IN cord-104317-t30dg6oj 108 2 a a DT cord-104317-t30dg6oj 108 3 short short JJ cord-104317-t30dg6oj 108 4 time time NN cord-104317-t30dg6oj 108 5 , , , cord-104317-t30dg6oj 108 6 the the DT cord-104317-t30dg6oj 108 7 virus virus NN cord-104317-t30dg6oj 108 8 returns return VBZ cord-104317-t30dg6oj 108 9 to to IN cord-104317-t30dg6oj 108 10 latency latency NN cord-104317-t30dg6oj 108 11 and and CC cord-104317-t30dg6oj 108 12 the the DT cord-104317-t30dg6oj 108 13 lesion lesion NN cord-104317-t30dg6oj 108 14 will will MD cord-104317-t30dg6oj 108 15 heal heal VB cord-104317-t30dg6oj 108 16 [ [ -LRB- cord-104317-t30dg6oj 108 17 52 52 CD cord-104317-t30dg6oj 108 18 ] ] -RRB- cord-104317-t30dg6oj 108 19 . . . cord-104317-t30dg6oj 109 1 The the DT cord-104317-t30dg6oj 109 2 success success NN cord-104317-t30dg6oj 109 3 of of IN cord-104317-t30dg6oj 109 4 this this DT cord-104317-t30dg6oj 109 5 strategy strategy NN cord-104317-t30dg6oj 109 6 of of IN cord-104317-t30dg6oj 109 7 latency latency NN cord-104317-t30dg6oj 109 8 and and CC cord-104317-t30dg6oj 109 9 mild mild JJ cord-104317-t30dg6oj 109 10 pathogenic pathogenic JJ cord-104317-t30dg6oj 109 11 effect effect NN cord-104317-t30dg6oj 109 12 is be VBZ cord-104317-t30dg6oj 109 13 made make VBN cord-104317-t30dg6oj 109 14 obvious obvious JJ cord-104317-t30dg6oj 109 15 by by IN cord-104317-t30dg6oj 109 16 the the DT cord-104317-t30dg6oj 109 17 fact fact NN cord-104317-t30dg6oj 109 18 that that IN cord-104317-t30dg6oj 109 19 approximately approximately RB cord-104317-t30dg6oj 109 20 two two CD cord-104317-t30dg6oj 109 21 - - HYPH cord-104317-t30dg6oj 109 22 thirds third NNS cord-104317-t30dg6oj 109 23 of of IN cord-104317-t30dg6oj 109 24 the the DT cord-104317-t30dg6oj 109 25 world world NN cord-104317-t30dg6oj 109 26 's 's POS cord-104317-t30dg6oj 109 27 population population NN cord-104317-t30dg6oj 109 28 is be VBZ cord-104317-t30dg6oj 109 29 infected infect VBN cord-104317-t30dg6oj 109 30 with with IN cord-104317-t30dg6oj 109 31 HSV-1 HSV-1 NNS cord-104317-t30dg6oj 109 32 [ [ -LRB- cord-104317-t30dg6oj 109 33 53 53 CD cord-104317-t30dg6oj 109 34 ] ] -RRB- cord-104317-t30dg6oj 109 35 . . . cord-104317-t30dg6oj 110 1 Non non JJ cord-104317-t30dg6oj 110 2 - - JJ cord-104317-t30dg6oj 110 3 conventional conventional JJ cord-104317-t30dg6oj 110 4 methods method NNS cord-104317-t30dg6oj 110 5 of of IN cord-104317-t30dg6oj 110 6 inoculation inoculation NN cord-104317-t30dg6oj 110 7 have have VBP cord-104317-t30dg6oj 110 8 arisen arise VBN cord-104317-t30dg6oj 110 9 concomitant concomitant JJ cord-104317-t30dg6oj 110 10 with with IN cord-104317-t30dg6oj 110 11 certain certain JJ cord-104317-t30dg6oj 110 12 human human JJ cord-104317-t30dg6oj 110 13 tendencies tendency NNS cord-104317-t30dg6oj 110 14 and and CC cord-104317-t30dg6oj 110 15 interactions interaction NNS cord-104317-t30dg6oj 110 16 . . . cord-104317-t30dg6oj 111 1 The the DT cord-104317-t30dg6oj 111 2 most most RBS cord-104317-t30dg6oj 111 3 common common JJ cord-104317-t30dg6oj 111 4 examples example NNS cord-104317-t30dg6oj 111 5 include include VBP cord-104317-t30dg6oj 111 6 intravenous intravenous JJ cord-104317-t30dg6oj 111 7 drug drug NN cord-104317-t30dg6oj 111 8 use use NN cord-104317-t30dg6oj 111 9 , , , cord-104317-t30dg6oj 111 10 blood blood NN cord-104317-t30dg6oj 111 11 transfusion transfusion NN cord-104317-t30dg6oj 111 12 , , , cord-104317-t30dg6oj 111 13 and and CC cord-104317-t30dg6oj 111 14 organ organ NN cord-104317-t30dg6oj 111 15 transplantation transplantation NN cord-104317-t30dg6oj 111 16 , , , cord-104317-t30dg6oj 111 17 all all DT cord-104317-t30dg6oj 111 18 of of IN cord-104317-t30dg6oj 111 19 which which WDT cord-104317-t30dg6oj 111 20 break break VBP cord-104317-t30dg6oj 111 21 typically typically RB cord-104317-t30dg6oj 111 22 impassable impassable JJ cord-104317-t30dg6oj 111 23 barriers barrier NNS cord-104317-t30dg6oj 111 24 [ [ -LRB- cord-104317-t30dg6oj 111 25 54 54 CD cord-104317-t30dg6oj 111 26 ] ] -RRB- cord-104317-t30dg6oj 111 27 . . . cord-104317-t30dg6oj 112 1 For for IN cord-104317-t30dg6oj 112 2 viruses virus NNS cord-104317-t30dg6oj 112 3 like like IN cord-104317-t30dg6oj 112 4 hepatitis hepatitis NN cord-104317-t30dg6oj 112 5 C C NNP cord-104317-t30dg6oj 112 6 virus virus NN cord-104317-t30dg6oj 112 7 ( ( -LRB- cord-104317-t30dg6oj 112 8 HCV HCV NNP cord-104317-t30dg6oj 112 9 ) ) -RRB- cord-104317-t30dg6oj 112 10 and and CC cord-104317-t30dg6oj 112 11 human human JJ cord-104317-t30dg6oj 112 12 immunodeficiency immunodeficiency NN cord-104317-t30dg6oj 112 13 virus virus NN cord-104317-t30dg6oj 112 14 ( ( -LRB- cord-104317-t30dg6oj 112 15 HIV HIV NNP cord-104317-t30dg6oj 112 16 ) ) -RRB- cord-104317-t30dg6oj 112 17 that that WDT cord-104317-t30dg6oj 112 18 circulate circulate VBP cord-104317-t30dg6oj 112 19 in in IN cord-104317-t30dg6oj 112 20 the the DT cord-104317-t30dg6oj 112 21 blood blood NN cord-104317-t30dg6oj 112 22 of of IN cord-104317-t30dg6oj 112 23 their -PRON- PRP$ cord-104317-t30dg6oj 112 24 host host NN cord-104317-t30dg6oj 112 25 , , , cord-104317-t30dg6oj 112 26 these these DT cord-104317-t30dg6oj 112 27 disruptions disruption NNS cord-104317-t30dg6oj 112 28 of of IN cord-104317-t30dg6oj 112 29 natural natural JJ cord-104317-t30dg6oj 112 30 barriers barrier NNS cord-104317-t30dg6oj 112 31 created create VBD cord-104317-t30dg6oj 112 32 a a DT cord-104317-t30dg6oj 112 33 heyday heyday NN cord-104317-t30dg6oj 112 34 for for IN cord-104317-t30dg6oj 112 35 transmission transmission NN cord-104317-t30dg6oj 112 36 . . . cord-104317-t30dg6oj 113 1 An an DT cord-104317-t30dg6oj 113 2 important important JJ cord-104317-t30dg6oj 113 3 development development NN cord-104317-t30dg6oj 113 4 of of IN cord-104317-t30dg6oj 113 5 modern modern JJ cord-104317-t30dg6oj 113 6 medicine medicine NN cord-104317-t30dg6oj 113 7 was be VBD cord-104317-t30dg6oj 113 8 the the DT cord-104317-t30dg6oj 113 9 implementation implementation NN cord-104317-t30dg6oj 113 10 of of IN cord-104317-t30dg6oj 113 11 standard standard JJ cord-104317-t30dg6oj 113 12 blood blood NN cord-104317-t30dg6oj 113 13 screening screening NN cord-104317-t30dg6oj 113 14 for for IN cord-104317-t30dg6oj 113 15 these these DT cord-104317-t30dg6oj 113 16 and and CC cord-104317-t30dg6oj 113 17 other other JJ cord-104317-t30dg6oj 113 18 persistent persistent JJ cord-104317-t30dg6oj 113 19 viruses virus NNS cord-104317-t30dg6oj 113 20 and and CC cord-104317-t30dg6oj 113 21 has have VBZ cord-104317-t30dg6oj 113 22 led lead VBN cord-104317-t30dg6oj 113 23 to to IN cord-104317-t30dg6oj 113 24 a a DT cord-104317-t30dg6oj 113 25 decrease decrease NN cord-104317-t30dg6oj 113 26 in in IN cord-104317-t30dg6oj 113 27 medically medically RB cord-104317-t30dg6oj 113 28 acquired acquire VBN cord-104317-t30dg6oj 113 29 disease disease NN cord-104317-t30dg6oj 113 30 [ [ -LRB- cord-104317-t30dg6oj 113 31 55 55 CD cord-104317-t30dg6oj 113 32 , , , cord-104317-t30dg6oj 113 33 56 56 CD cord-104317-t30dg6oj 113 34 ] ] -RRB- cord-104317-t30dg6oj 113 35 . . . cord-104317-t30dg6oj 114 1 Because because IN cord-104317-t30dg6oj 114 2 of of IN cord-104317-t30dg6oj 114 3 the the DT cord-104317-t30dg6oj 114 4 longevity longevity NN cord-104317-t30dg6oj 114 5 of of IN cord-104317-t30dg6oj 114 6 asymptomatic asymptomatic JJ cord-104317-t30dg6oj 114 7 interaction interaction NN cord-104317-t30dg6oj 114 8 , , , cord-104317-t30dg6oj 114 9 those those DT cord-104317-t30dg6oj 114 10 who who WP cord-104317-t30dg6oj 114 11 are be VBP cord-104317-t30dg6oj 114 12 infected infect VBN cord-104317-t30dg6oj 114 13 with with IN cord-104317-t30dg6oj 114 14 persistent persistent JJ cord-104317-t30dg6oj 114 15 viruses virus NNS cord-104317-t30dg6oj 114 16 may may MD cord-104317-t30dg6oj 114 17 not not RB cord-104317-t30dg6oj 114 18 know know VB cord-104317-t30dg6oj 114 19 for for IN cord-104317-t30dg6oj 114 20 years year NNS cord-104317-t30dg6oj 114 21 . . . cord-104317-t30dg6oj 115 1 This this DT cord-104317-t30dg6oj 115 2 has have VBZ cord-104317-t30dg6oj 115 3 consequences consequence NNS cord-104317-t30dg6oj 115 4 not not RB cord-104317-t30dg6oj 115 5 only only RB cord-104317-t30dg6oj 115 6 for for IN cord-104317-t30dg6oj 115 7 transmission transmission NN cord-104317-t30dg6oj 115 8 to to IN cord-104317-t30dg6oj 115 9 others other NNS cord-104317-t30dg6oj 115 10 , , , cord-104317-t30dg6oj 115 11 but but CC cord-104317-t30dg6oj 115 12 also also RB cord-104317-t30dg6oj 115 13 for for IN cord-104317-t30dg6oj 115 14 eventual eventual JJ cord-104317-t30dg6oj 115 15 progression progression NN cord-104317-t30dg6oj 115 16 to to IN cord-104317-t30dg6oj 115 17 disease disease NN cord-104317-t30dg6oj 115 18 , , , cord-104317-t30dg6oj 115 19 as as IN cord-104317-t30dg6oj 115 20 treatment treatment NN cord-104317-t30dg6oj 115 21 is be VBZ cord-104317-t30dg6oj 115 22 delayed delay VBN cord-104317-t30dg6oj 115 23 until until IN cord-104317-t30dg6oj 115 24 symptoms symptom NNS cord-104317-t30dg6oj 115 25 emerge emerge VBP cord-104317-t30dg6oj 115 26 when when WRB cord-104317-t30dg6oj 115 27 the the DT cord-104317-t30dg6oj 115 28 damage damage NN cord-104317-t30dg6oj 115 29 is be VBZ cord-104317-t30dg6oj 115 30 often often RB cord-104317-t30dg6oj 115 31 irreparable irreparable JJ cord-104317-t30dg6oj 115 32 . . . cord-104317-t30dg6oj 116 1 For for IN cord-104317-t30dg6oj 116 2 HIV HIV NNP cord-104317-t30dg6oj 116 3 , , , cord-104317-t30dg6oj 116 4 the the DT cord-104317-t30dg6oj 116 5 condition condition NN cord-104317-t30dg6oj 116 6 of of IN cord-104317-t30dg6oj 116 7 Acquired Acquired NNP cord-104317-t30dg6oj 116 8 Immune Immune NNP cord-104317-t30dg6oj 116 9 Deficiency Deficiency NNP cord-104317-t30dg6oj 116 10 Syndrome Syndrome NNP cord-104317-t30dg6oj 116 11 ( ( -LRB- cord-104317-t30dg6oj 116 12 AIDS AIDS NNP cord-104317-t30dg6oj 116 13 ) ) -RRB- cord-104317-t30dg6oj 116 14 weakens weaken VBZ cord-104317-t30dg6oj 116 15 the the DT cord-104317-t30dg6oj 116 16 immune immune JJ cord-104317-t30dg6oj 116 17 system system NN cord-104317-t30dg6oj 116 18 drastically drastically RB cord-104317-t30dg6oj 116 19 , , , cord-104317-t30dg6oj 116 20 allowing allow VBG cord-104317-t30dg6oj 116 21 opportunistic opportunistic JJ cord-104317-t30dg6oj 116 22 microbes microbe NNS cord-104317-t30dg6oj 116 23 to to TO cord-104317-t30dg6oj 116 24 cause cause VB cord-104317-t30dg6oj 116 25 fatal fatal JJ cord-104317-t30dg6oj 116 26 disease disease NN cord-104317-t30dg6oj 116 27 [ [ -LRB- cord-104317-t30dg6oj 116 28 57 57 CD cord-104317-t30dg6oj 116 29 ] ] -RRB- cord-104317-t30dg6oj 116 30 . . . cord-104317-t30dg6oj 117 1 HCV HCV NNP cord-104317-t30dg6oj 117 2 is be VBZ cord-104317-t30dg6oj 117 3 the the DT cord-104317-t30dg6oj 117 4 most most RBS cord-104317-t30dg6oj 117 5 common common JJ cord-104317-t30dg6oj 117 6 cause cause NN cord-104317-t30dg6oj 117 7 of of IN cord-104317-t30dg6oj 117 8 chronic chronic JJ cord-104317-t30dg6oj 117 9 liver liver NN cord-104317-t30dg6oj 117 10 disease disease NN cord-104317-t30dg6oj 117 11 , , , cord-104317-t30dg6oj 117 12 cirrhosis cirrhosis NN cord-104317-t30dg6oj 117 13 , , , cord-104317-t30dg6oj 117 14 and and CC cord-104317-t30dg6oj 117 15 liver liver NN cord-104317-t30dg6oj 117 16 cancer cancer NN cord-104317-t30dg6oj 117 17 in in IN cord-104317-t30dg6oj 117 18 the the DT cord-104317-t30dg6oj 117 19 form form NN cord-104317-t30dg6oj 117 20 of of IN cord-104317-t30dg6oj 117 21 Hepatocellular Hepatocellular NNP cord-104317-t30dg6oj 117 22 Carcinoma Carcinoma NNP cord-104317-t30dg6oj 117 23 , , , cord-104317-t30dg6oj 117 24 all all DT cord-104317-t30dg6oj 117 25 caused cause VBN cord-104317-t30dg6oj 117 26 by by IN cord-104317-t30dg6oj 117 27 years year NNS cord-104317-t30dg6oj 117 28 of of IN cord-104317-t30dg6oj 117 29 persistent persistent JJ cord-104317-t30dg6oj 117 30 viral viral JJ cord-104317-t30dg6oj 117 31 presence presence NN cord-104317-t30dg6oj 117 32 [ [ -LRB- cord-104317-t30dg6oj 117 33 58 58 CD cord-104317-t30dg6oj 117 34 , , , cord-104317-t30dg6oj 117 35 59 59 CD cord-104317-t30dg6oj 117 36 ] ] -RRB- cord-104317-t30dg6oj 117 37 . . . cord-104317-t30dg6oj 118 1 The the DT cord-104317-t30dg6oj 118 2 delayed delay VBN cord-104317-t30dg6oj 118 3 onset onset NN cord-104317-t30dg6oj 118 4 and and CC cord-104317-t30dg6oj 118 5 long long JJ cord-104317-t30dg6oj 118 6 - - HYPH cord-104317-t30dg6oj 118 7 term term NN cord-104317-t30dg6oj 118 8 homeostasis homeostasis NN cord-104317-t30dg6oj 118 9 of of IN cord-104317-t30dg6oj 118 10 persistent persistent JJ cord-104317-t30dg6oj 118 11 viruses virus NNS cord-104317-t30dg6oj 118 12 within within IN cord-104317-t30dg6oj 118 13 their -PRON- PRP$ cord-104317-t30dg6oj 118 14 hosts host NNS cord-104317-t30dg6oj 118 15 makes make VBZ cord-104317-t30dg6oj 118 16 them -PRON- PRP cord-104317-t30dg6oj 118 17 a a DT cord-104317-t30dg6oj 118 18 unique unique JJ cord-104317-t30dg6oj 118 19 class class NN cord-104317-t30dg6oj 118 20 within within IN cord-104317-t30dg6oj 118 21 the the DT cord-104317-t30dg6oj 118 22 human human JJ cord-104317-t30dg6oj 118 23 virome virome NN cord-104317-t30dg6oj 118 24 . . . cord-104317-t30dg6oj 119 1 Understanding understand VBG cord-104317-t30dg6oj 119 2 the the DT cord-104317-t30dg6oj 119 3 biology biology NN cord-104317-t30dg6oj 119 4 of of IN cord-104317-t30dg6oj 119 5 these these DT cord-104317-t30dg6oj 119 6 viruses virus NNS cord-104317-t30dg6oj 119 7 and and CC cord-104317-t30dg6oj 119 8 the the DT cord-104317-t30dg6oj 119 9 development development NN cord-104317-t30dg6oj 119 10 of of IN cord-104317-t30dg6oj 119 11 methods method NNS cord-104317-t30dg6oj 119 12 to to TO cord-104317-t30dg6oj 119 13 control control VB cord-104317-t30dg6oj 119 14 and and CC cord-104317-t30dg6oj 119 15 eliminate eliminate VB cord-104317-t30dg6oj 119 16 them -PRON- PRP cord-104317-t30dg6oj 119 17 is be VBZ cord-104317-t30dg6oj 119 18 an an DT cord-104317-t30dg6oj 119 19 area area NN cord-104317-t30dg6oj 119 20 of of IN cord-104317-t30dg6oj 119 21 much much JJ cord-104317-t30dg6oj 119 22 importance importance NN cord-104317-t30dg6oj 119 23 in in IN cord-104317-t30dg6oj 119 24 future future JJ cord-104317-t30dg6oj 119 25 medical medical JJ cord-104317-t30dg6oj 119 26 science science NN cord-104317-t30dg6oj 119 27 . . . cord-104317-t30dg6oj 120 1 Additionally additionally RB cord-104317-t30dg6oj 120 2 , , , cord-104317-t30dg6oj 120 3 further further JJ cord-104317-t30dg6oj 120 4 characterization characterization NN cord-104317-t30dg6oj 120 5 of of IN cord-104317-t30dg6oj 120 6 the the DT cord-104317-t30dg6oj 120 7 human human JJ cord-104317-t30dg6oj 120 8 virome virome NNP cord-104317-t30dg6oj 120 9 is be VBZ cord-104317-t30dg6oj 120 10 likely likely JJ cord-104317-t30dg6oj 120 11 to to TO cord-104317-t30dg6oj 120 12 uncover uncover VB cord-104317-t30dg6oj 120 13 more more JJR cord-104317-t30dg6oj 120 14 viruses virus NNS cord-104317-t30dg6oj 120 15 that that WDT cord-104317-t30dg6oj 120 16 persistently persistently RB cord-104317-t30dg6oj 120 17 infect infect VBP cord-104317-t30dg6oj 120 18 humans human NNS cord-104317-t30dg6oj 120 19 [ [ -LRB- cord-104317-t30dg6oj 120 20 31 31 CD cord-104317-t30dg6oj 120 21 ] ] -RRB- cord-104317-t30dg6oj 120 22 , , , cord-104317-t30dg6oj 120 23 and and CC cord-104317-t30dg6oj 120 24 such such JJ cord-104317-t30dg6oj 120 25 discoveries discovery NNS cord-104317-t30dg6oj 120 26 could could MD cord-104317-t30dg6oj 120 27 pave pave VB cord-104317-t30dg6oj 120 28 the the DT cord-104317-t30dg6oj 120 29 way way NN cord-104317-t30dg6oj 120 30 for for IN cord-104317-t30dg6oj 120 31 the the DT cord-104317-t30dg6oj 120 32 treatment treatment NN cord-104317-t30dg6oj 120 33 of of IN cord-104317-t30dg6oj 120 34 diseases disease NNS cord-104317-t30dg6oj 120 35 of of IN cord-104317-t30dg6oj 120 36 currently currently RB cord-104317-t30dg6oj 120 37 unknown unknown JJ cord-104317-t30dg6oj 120 38 etiology etiology NN cord-104317-t30dg6oj 120 39 . . . cord-104317-t30dg6oj 121 1 As as IN cord-104317-t30dg6oj 121 2 will will MD cord-104317-t30dg6oj 121 3 be be VB cord-104317-t30dg6oj 121 4 discussed discuss VBN cord-104317-t30dg6oj 121 5 in in IN cord-104317-t30dg6oj 121 6 later later JJ cord-104317-t30dg6oj 121 7 sections section NNS cord-104317-t30dg6oj 121 8 , , , cord-104317-t30dg6oj 121 9 not not RB cord-104317-t30dg6oj 121 10 all all DT cord-104317-t30dg6oj 121 11 viruses virus NNS cord-104317-t30dg6oj 121 12 are be VBP cord-104317-t30dg6oj 121 13 pathogenic pathogenic JJ cord-104317-t30dg6oj 121 14 . . . cord-104317-t30dg6oj 122 1 Herein herein RB cord-104317-t30dg6oj 122 2 , , , cord-104317-t30dg6oj 122 3 I -PRON- PRP cord-104317-t30dg6oj 122 4 classify classify VBP cord-104317-t30dg6oj 122 5 viruses virus NNS cord-104317-t30dg6oj 122 6 that that WDT cord-104317-t30dg6oj 122 7 impact impact NN cord-104317-t30dg6oj 122 8 host host NN cord-104317-t30dg6oj 122 9 physiology physiology NN cord-104317-t30dg6oj 122 10 without without IN cord-104317-t30dg6oj 122 11 directly directly RB cord-104317-t30dg6oj 122 12 eliciting elicit VBG cord-104317-t30dg6oj 122 13 a a DT cord-104317-t30dg6oj 122 14 disease disease NN cord-104317-t30dg6oj 122 15 state state NN cord-104317-t30dg6oj 122 16 as as IN cord-104317-t30dg6oj 122 17 atypically atypically RB cord-104317-t30dg6oj 122 18 pathogenic pathogenic JJ cord-104317-t30dg6oj 122 19 viruses virus NNS cord-104317-t30dg6oj 122 20 . . . cord-104317-t30dg6oj 123 1 For for IN cord-104317-t30dg6oj 123 2 example example NN cord-104317-t30dg6oj 123 3 , , , cord-104317-t30dg6oj 123 4 some some DT cord-104317-t30dg6oj 123 5 viruses virus NNS cord-104317-t30dg6oj 123 6 infect infect VBP cord-104317-t30dg6oj 123 7 humans human NNS cord-104317-t30dg6oj 123 8 without without IN cord-104317-t30dg6oj 123 9 ever ever RB cord-104317-t30dg6oj 123 10 causing cause VBG cord-104317-t30dg6oj 123 11 disease disease NN cord-104317-t30dg6oj 123 12 while while IN cord-104317-t30dg6oj 123 13 others other NNS cord-104317-t30dg6oj 123 14 inhabit inhabit VBP cord-104317-t30dg6oj 123 15 and and CC cord-104317-t30dg6oj 123 16 change change VBP cord-104317-t30dg6oj 123 17 the the DT cord-104317-t30dg6oj 123 18 composition composition NN cord-104317-t30dg6oj 123 19 of of IN cord-104317-t30dg6oj 123 20 the the DT cord-104317-t30dg6oj 123 21 human human JJ cord-104317-t30dg6oj 123 22 microbiome microbiome NN cord-104317-t30dg6oj 123 23 without without IN cord-104317-t30dg6oj 123 24 ever ever RB cord-104317-t30dg6oj 123 25 infecting infect VBG cord-104317-t30dg6oj 123 26 human human JJ cord-104317-t30dg6oj 123 27 cells cell NNS cord-104317-t30dg6oj 123 28 . . . cord-104317-t30dg6oj 124 1 Since since IN cord-104317-t30dg6oj 124 2 our -PRON- PRP$ cord-104317-t30dg6oj 124 3 immune immune JJ cord-104317-t30dg6oj 124 4 system system NN cord-104317-t30dg6oj 124 5 ca can MD cord-104317-t30dg6oj 124 6 n't not RB cord-104317-t30dg6oj 124 7 tell tell VB cord-104317-t30dg6oj 124 8 the the DT cord-104317-t30dg6oj 124 9 difference difference NN cord-104317-t30dg6oj 124 10 between between IN cord-104317-t30dg6oj 124 11 harmful harmful JJ cord-104317-t30dg6oj 124 12 or or CC cord-104317-t30dg6oj 124 13 benign benign JJ cord-104317-t30dg6oj 124 14 viral viral JJ cord-104317-t30dg6oj 124 15 signatures signature NNS cord-104317-t30dg6oj 124 16 , , , cord-104317-t30dg6oj 124 17 the the DT cord-104317-t30dg6oj 124 18 mere mere JJ cord-104317-t30dg6oj 124 19 presence presence NN cord-104317-t30dg6oj 124 20 of of IN cord-104317-t30dg6oj 124 21 these these DT cord-104317-t30dg6oj 124 22 viruses virus NNS cord-104317-t30dg6oj 124 23 harbors harbor VBZ cord-104317-t30dg6oj 124 24 potential potential JJ cord-104317-t30dg6oj 124 25 to to TO cord-104317-t30dg6oj 124 26 cause cause VB cord-104317-t30dg6oj 124 27 disease disease NN cord-104317-t30dg6oj 124 28 . . . cord-104317-t30dg6oj 125 1 So so RB cord-104317-t30dg6oj 125 2 far far RB cord-104317-t30dg6oj 125 3 , , , cord-104317-t30dg6oj 125 4 this this DT cord-104317-t30dg6oj 125 5 type type NN cord-104317-t30dg6oj 125 6 of of IN cord-104317-t30dg6oj 125 7 interaction interaction NN cord-104317-t30dg6oj 125 8 has have VBZ cord-104317-t30dg6oj 125 9 not not RB cord-104317-t30dg6oj 125 10 been be VBN cord-104317-t30dg6oj 125 11 defined define VBN cord-104317-t30dg6oj 125 12 as as IN cord-104317-t30dg6oj 125 13 a a DT cord-104317-t30dg6oj 125 14 facet facet NN cord-104317-t30dg6oj 125 15 of of IN cord-104317-t30dg6oj 125 16 the the DT cord-104317-t30dg6oj 125 17 virome virome NN cord-104317-t30dg6oj 125 18 , , , cord-104317-t30dg6oj 125 19 but but CC cord-104317-t30dg6oj 125 20 in in IN cord-104317-t30dg6oj 125 21 this this DT cord-104317-t30dg6oj 125 22 section section NN cord-104317-t30dg6oj 125 23 I -PRON- PRP cord-104317-t30dg6oj 125 24 will will MD cord-104317-t30dg6oj 125 25 review review VB cord-104317-t30dg6oj 125 26 examples example NNS cord-104317-t30dg6oj 125 27 from from IN cord-104317-t30dg6oj 125 28 the the DT cord-104317-t30dg6oj 125 29 scientific scientific JJ cord-104317-t30dg6oj 125 30 literature literature NN cord-104317-t30dg6oj 125 31 that that WDT cord-104317-t30dg6oj 125 32 hint hint VBP cord-104317-t30dg6oj 125 33 at at IN cord-104317-t30dg6oj 125 34 such such JJ cord-104317-t30dg6oj 125 35 scenarios scenario NNS cord-104317-t30dg6oj 125 36 . . . cord-104317-t30dg6oj 126 1 Endogenous endogenous JJ cord-104317-t30dg6oj 126 2 retroelements retroelement NNS cord-104317-t30dg6oj 126 3 ( ( -LRB- cord-104317-t30dg6oj 126 4 EREs EREs NNP cord-104317-t30dg6oj 126 5 ) ) -RRB- cord-104317-t30dg6oj 126 6 represent represent VB cord-104317-t30dg6oj 126 7 a a DT cord-104317-t30dg6oj 126 8 unique unique JJ cord-104317-t30dg6oj 126 9 class class NN cord-104317-t30dg6oj 126 10 of of IN cord-104317-t30dg6oj 126 11 human human NN cord-104317-t30dg6oj 126 12 - - HYPH cord-104317-t30dg6oj 126 13 colonizing colonize VBG cord-104317-t30dg6oj 126 14 viral viral JJ cord-104317-t30dg6oj 126 15 material material NN cord-104317-t30dg6oj 126 16 that that WDT cord-104317-t30dg6oj 126 17 is be VBZ cord-104317-t30dg6oj 126 18 resident resident JJ cord-104317-t30dg6oj 126 19 in in IN cord-104317-t30dg6oj 126 20 the the DT cord-104317-t30dg6oj 126 21 germ germ NN cord-104317-t30dg6oj 126 22 line line NN cord-104317-t30dg6oj 126 23 and and CC cord-104317-t30dg6oj 126 24 include include VBP cord-104317-t30dg6oj 126 25 endogenous endogenous JJ cord-104317-t30dg6oj 126 26 retroviruses retrovirus NNS cord-104317-t30dg6oj 126 27 ( ( -LRB- cord-104317-t30dg6oj 126 28 ERVs ERVs NNP cord-104317-t30dg6oj 126 29 ) ) -RRB- cord-104317-t30dg6oj 126 30 , , , cord-104317-t30dg6oj 126 31 retrotransposons retrotransposon NNS cord-104317-t30dg6oj 126 32 , , , cord-104317-t30dg6oj 126 33 and and CC cord-104317-t30dg6oj 126 34 retrotranscripts retrotranscripts NNP cord-104317-t30dg6oj 126 35 [ [ -LRB- cord-104317-t30dg6oj 126 36 60 60 CD cord-104317-t30dg6oj 126 37 ] ] -RRB- cord-104317-t30dg6oj 126 38 . . . cord-104317-t30dg6oj 127 1 While while IN cord-104317-t30dg6oj 127 2 the the DT cord-104317-t30dg6oj 127 3 general general JJ cord-104317-t30dg6oj 127 4 classification classification NN cord-104317-t30dg6oj 127 5 of of IN cord-104317-t30dg6oj 127 6 these these DT cord-104317-t30dg6oj 127 7 genetic genetic JJ cord-104317-t30dg6oj 127 8 elements element NNS cord-104317-t30dg6oj 127 9 will will MD cord-104317-t30dg6oj 127 10 be be VB cord-104317-t30dg6oj 127 11 defined define VBN cord-104317-t30dg6oj 127 12 in in IN cord-104317-t30dg6oj 127 13 this this DT cord-104317-t30dg6oj 127 14 work work NN cord-104317-t30dg6oj 127 15 as as IN cord-104317-t30dg6oj 127 16 mutualistic mutualistic JJ cord-104317-t30dg6oj 127 17 ( ( -LRB- cord-104317-t30dg6oj 127 18 see see VB cord-104317-t30dg6oj 127 19 The the DT cord-104317-t30dg6oj 127 20 Mutualistic Mutualistic NNP cord-104317-t30dg6oj 127 21 Virome Virome NNP cord-104317-t30dg6oj 127 22 , , , cord-104317-t30dg6oj 127 23 below below RB cord-104317-t30dg6oj 127 24 ) ) -RRB- cord-104317-t30dg6oj 127 25 , , , cord-104317-t30dg6oj 127 26 it -PRON- PRP cord-104317-t30dg6oj 127 27 is be VBZ cord-104317-t30dg6oj 127 28 evident evident JJ cord-104317-t30dg6oj 127 29 from from IN cord-104317-t30dg6oj 127 30 a a DT cord-104317-t30dg6oj 127 31 number number NN cord-104317-t30dg6oj 127 32 of of IN cord-104317-t30dg6oj 127 33 studies study NNS cord-104317-t30dg6oj 127 34 that that WDT cord-104317-t30dg6oj 127 35 they -PRON- PRP cord-104317-t30dg6oj 127 36 can can MD cord-104317-t30dg6oj 127 37 sometimes sometimes RB cord-104317-t30dg6oj 127 38 contribute contribute VB cord-104317-t30dg6oj 127 39 to to IN cord-104317-t30dg6oj 127 40 pathogenesis pathogenesis NN cord-104317-t30dg6oj 127 41 . . . cord-104317-t30dg6oj 128 1 In in IN cord-104317-t30dg6oj 128 2 the the DT cord-104317-t30dg6oj 128 3 autoimmune autoimmune JJ cord-104317-t30dg6oj 128 4 disease disease NN cord-104317-t30dg6oj 128 5 Multiple Multiple NNP cord-104317-t30dg6oj 128 6 Sclerosis Sclerosis NNP cord-104317-t30dg6oj 128 7 ( ( -LRB- cord-104317-t30dg6oj 128 8 MS MS NNP cord-104317-t30dg6oj 128 9 ) ) -RRB- cord-104317-t30dg6oj 128 10 , , , cord-104317-t30dg6oj 128 11 human human JJ cord-104317-t30dg6oj 128 12 endogenous endogenous JJ cord-104317-t30dg6oj 128 13 retrovirus retrovirus NN cord-104317-t30dg6oj 128 14 ( ( -LRB- cord-104317-t30dg6oj 128 15 HERV HERV NNP cord-104317-t30dg6oj 128 16 ) ) -RRB- cord-104317-t30dg6oj 128 17 syncytin syncytin JJ cord-104317-t30dg6oj 128 18 expression expression NN cord-104317-t30dg6oj 128 19 is be VBZ cord-104317-t30dg6oj 128 20 upregulated upregulate VBN cord-104317-t30dg6oj 128 21 in in IN cord-104317-t30dg6oj 128 22 lesions lesion NNS cord-104317-t30dg6oj 128 23 and and CC cord-104317-t30dg6oj 128 24 leads lead VBZ cord-104317-t30dg6oj 128 25 to to IN cord-104317-t30dg6oj 128 26 an an DT cord-104317-t30dg6oj 128 27 increase increase NN cord-104317-t30dg6oj 128 28 of of IN cord-104317-t30dg6oj 128 29 cellular cellular JJ cord-104317-t30dg6oj 128 30 protein protein NN cord-104317-t30dg6oj 128 31 oxidation oxidation NN cord-104317-t30dg6oj 128 32 and and CC cord-104317-t30dg6oj 128 33 destruction destruction NN cord-104317-t30dg6oj 128 34 of of IN cord-104317-t30dg6oj 128 35 oligodendrocytes oligodendrocyte NNS cord-104317-t30dg6oj 128 36 [ [ -LRB- cord-104317-t30dg6oj 128 37 61 61 CD cord-104317-t30dg6oj 128 38 ] ] -RRB- cord-104317-t30dg6oj 128 39 . . . cord-104317-t30dg6oj 129 1 Another another DT cord-104317-t30dg6oj 129 2 possible possible JJ cord-104317-t30dg6oj 129 3 autoimmune autoimmune JJ cord-104317-t30dg6oj 129 4 contribution contribution NN cord-104317-t30dg6oj 129 5 of of IN cord-104317-t30dg6oj 129 6 EREs EREs NNP cord-104317-t30dg6oj 129 7 is be VBZ cord-104317-t30dg6oj 129 8 by by IN cord-104317-t30dg6oj 129 9 their -PRON- PRP$ cord-104317-t30dg6oj 129 10 engagement engagement NN cord-104317-t30dg6oj 129 11 of of IN cord-104317-t30dg6oj 129 12 nucleic nucleic JJ cord-104317-t30dg6oj 129 13 acid acid NN cord-104317-t30dg6oj 129 14 pattern pattern NN cord-104317-t30dg6oj 129 15 recognition recognition NN cord-104317-t30dg6oj 129 16 and and CC cord-104317-t30dg6oj 129 17 downstream downstream JJ cord-104317-t30dg6oj 129 18 immune immune JJ cord-104317-t30dg6oj 129 19 activation activation NN cord-104317-t30dg6oj 129 20 during during IN cord-104317-t30dg6oj 129 21 both both CC cord-104317-t30dg6oj 129 22 their -PRON- PRP$ cord-104317-t30dg6oj 129 23 RNA RNA NNP cord-104317-t30dg6oj 129 24 and and CC cord-104317-t30dg6oj 129 25 cDNA cdna NN cord-104317-t30dg6oj 129 26 synthesis synthesis NN cord-104317-t30dg6oj 129 27 [ [ -LRB- cord-104317-t30dg6oj 129 28 62 62 CD cord-104317-t30dg6oj 129 29 , , , cord-104317-t30dg6oj 129 30 63 63 CD cord-104317-t30dg6oj 129 31 ] ] -RRB- cord-104317-t30dg6oj 129 32 . . . cord-104317-t30dg6oj 130 1 Carcinogenesis carcinogenesis NN cord-104317-t30dg6oj 130 2 may may MD cord-104317-t30dg6oj 130 3 also also RB cord-104317-t30dg6oj 130 4 occur occur VB cord-104317-t30dg6oj 130 5 , , , cord-104317-t30dg6oj 130 6 as as IN cord-104317-t30dg6oj 130 7 exemplified exemplify VBN cord-104317-t30dg6oj 130 8 by by IN cord-104317-t30dg6oj 130 9 the the DT cord-104317-t30dg6oj 130 10 Rec Rec NNP cord-104317-t30dg6oj 130 11 protein protein NN cord-104317-t30dg6oj 130 12 of of IN cord-104317-t30dg6oj 130 13 HERV HERV NNP cord-104317-t30dg6oj 130 14 - - HYPH cord-104317-t30dg6oj 130 15 K(HML2 K(HML2 NNP cord-104317-t30dg6oj 130 16 ) ) -RRB- cord-104317-t30dg6oj 130 17 , , , cord-104317-t30dg6oj 130 18 which which WDT cord-104317-t30dg6oj 130 19 can can MD cord-104317-t30dg6oj 130 20 facilitate facilitate VB cord-104317-t30dg6oj 130 21 tumorigenesis tumorigenesis NN cord-104317-t30dg6oj 130 22 when when WRB cord-104317-t30dg6oj 130 23 expressed express VBN cord-104317-t30dg6oj 130 24 in in IN cord-104317-t30dg6oj 130 25 mice mouse NNS cord-104317-t30dg6oj 130 26 [ [ -LRB- cord-104317-t30dg6oj 130 27 64 64 CD cord-104317-t30dg6oj 130 28 ] ] -RRB- cord-104317-t30dg6oj 130 29 . . . cord-104317-t30dg6oj 131 1 A a DT cord-104317-t30dg6oj 131 2 final final JJ cord-104317-t30dg6oj 131 3 example example NN cord-104317-t30dg6oj 131 4 of of IN cord-104317-t30dg6oj 131 5 deleterious deleterious JJ cord-104317-t30dg6oj 131 6 consequences consequence NNS cord-104317-t30dg6oj 131 7 conferred confer VBN cord-104317-t30dg6oj 131 8 by by IN cord-104317-t30dg6oj 131 9 EREs EREs NNP cord-104317-t30dg6oj 131 10 is be VBZ cord-104317-t30dg6oj 131 11 their -PRON- PRP$ cord-104317-t30dg6oj 131 12 ability ability NN cord-104317-t30dg6oj 131 13 to to TO cord-104317-t30dg6oj 131 14 destabilize destabilize VB cord-104317-t30dg6oj 131 15 the the DT cord-104317-t30dg6oj 131 16 genome genome NN cord-104317-t30dg6oj 131 17 via via IN cord-104317-t30dg6oj 131 18 insertion insertion NN cord-104317-t30dg6oj 131 19 , , , cord-104317-t30dg6oj 131 20 rearrangement rearrangement NN cord-104317-t30dg6oj 131 21 , , , cord-104317-t30dg6oj 131 22 and and CC cord-104317-t30dg6oj 131 23 deletion deletion NN cord-104317-t30dg6oj 131 24 [ [ -LRB- cord-104317-t30dg6oj 131 25 65 65 CD cord-104317-t30dg6oj 131 26 ] ] -RRB- cord-104317-t30dg6oj 131 27 . . . cord-104317-t30dg6oj 132 1 Continued continued JJ cord-104317-t30dg6oj 132 2 exploration exploration NN cord-104317-t30dg6oj 132 3 is be VBZ cord-104317-t30dg6oj 132 4 necessary necessary JJ cord-104317-t30dg6oj 132 5 to to TO cord-104317-t30dg6oj 132 6 expand expand VB cord-104317-t30dg6oj 132 7 upon upon IN cord-104317-t30dg6oj 132 8 these these DT cord-104317-t30dg6oj 132 9 data datum NNS cord-104317-t30dg6oj 132 10 to to TO cord-104317-t30dg6oj 132 11 elucidate elucidate VB cord-104317-t30dg6oj 132 12 the the DT cord-104317-t30dg6oj 132 13 mechanisms mechanism NNS cord-104317-t30dg6oj 132 14 behind behind IN cord-104317-t30dg6oj 132 15 the the DT cord-104317-t30dg6oj 132 16 negative negative JJ cord-104317-t30dg6oj 132 17 impacts impact NNS cord-104317-t30dg6oj 132 18 of of IN cord-104317-t30dg6oj 132 19 EREs ere NNS cord-104317-t30dg6oj 132 20 on on IN cord-104317-t30dg6oj 132 21 human human JJ cord-104317-t30dg6oj 132 22 health health NN cord-104317-t30dg6oj 132 23 . . . cord-104317-t30dg6oj 133 1 Bacteriophages bacteriophage NNS cord-104317-t30dg6oj 133 2 ( ( -LRB- cord-104317-t30dg6oj 133 3 from from IN cord-104317-t30dg6oj 133 4 here here RB cord-104317-t30dg6oj 133 5 , , , cord-104317-t30dg6oj 133 6 referred refer VBD cord-104317-t30dg6oj 133 7 to to IN cord-104317-t30dg6oj 133 8 as as IN cord-104317-t30dg6oj 133 9 phages phage NNS cord-104317-t30dg6oj 133 10 ) ) -RRB- cord-104317-t30dg6oj 133 11 , , , cord-104317-t30dg6oj 133 12 which which WDT cord-104317-t30dg6oj 133 13 are be VBP cord-104317-t30dg6oj 133 14 canonically canonically RB cord-104317-t30dg6oj 133 15 classified classify VBN cord-104317-t30dg6oj 133 16 as as IN cord-104317-t30dg6oj 133 17 commensals commensal NNS cord-104317-t30dg6oj 133 18 ( ( -LRB- cord-104317-t30dg6oj 133 19 see see VB cord-104317-t30dg6oj 133 20 The the DT cord-104317-t30dg6oj 133 21 Commensal Commensal NNP cord-104317-t30dg6oj 133 22 Virome Virome NNP cord-104317-t30dg6oj 133 23 , , , cord-104317-t30dg6oj 133 24 below below RB cord-104317-t30dg6oj 133 25 ) ) -RRB- cord-104317-t30dg6oj 133 26 , , , cord-104317-t30dg6oj 133 27 may may MD cord-104317-t30dg6oj 133 28 also also RB cord-104317-t30dg6oj 133 29 play play VB cord-104317-t30dg6oj 133 30 an an DT cord-104317-t30dg6oj 133 31 atypically atypically RB cord-104317-t30dg6oj 133 32 negative negative JJ cord-104317-t30dg6oj 133 33 role role NN cord-104317-t30dg6oj 133 34 . . . cord-104317-t30dg6oj 134 1 While while IN cord-104317-t30dg6oj 134 2 these these DT cord-104317-t30dg6oj 134 3 viruses virus NNS cord-104317-t30dg6oj 134 4 do do VBP cord-104317-t30dg6oj 134 5 not not RB cord-104317-t30dg6oj 134 6 infect infect VB cord-104317-t30dg6oj 134 7 human human JJ cord-104317-t30dg6oj 134 8 cells cell NNS cord-104317-t30dg6oj 134 9 , , , cord-104317-t30dg6oj 134 10 the the DT cord-104317-t30dg6oj 134 11 estimated estimate VBN cord-104317-t30dg6oj 134 12 10 10 CD cord-104317-t30dg6oj 134 13 15 15 CD cord-104317-t30dg6oj 134 14 phages phage NNS cord-104317-t30dg6oj 134 15 present present JJ cord-104317-t30dg6oj 134 16 in in IN cord-104317-t30dg6oj 134 17 the the DT cord-104317-t30dg6oj 134 18 human human JJ cord-104317-t30dg6oj 134 19 gut gut NN cord-104317-t30dg6oj 134 20 [ [ -LRB- cord-104317-t30dg6oj 134 21 66 66 CD cord-104317-t30dg6oj 134 22 ] ] -RRB- cord-104317-t30dg6oj 134 23 and and CC cord-104317-t30dg6oj 134 24 those those DT cord-104317-t30dg6oj 134 25 elsewhere elsewhere RB cord-104317-t30dg6oj 134 26 on on IN cord-104317-t30dg6oj 134 27 the the DT cord-104317-t30dg6oj 134 28 body body NN cord-104317-t30dg6oj 134 29 are be VBP cord-104317-t30dg6oj 134 30 not not RB cord-104317-t30dg6oj 134 31 likely likely JJ cord-104317-t30dg6oj 134 32 to to TO cord-104317-t30dg6oj 134 33 be be VB cord-104317-t30dg6oj 134 34 completely completely RB cord-104317-t30dg6oj 134 35 benign benign JJ cord-104317-t30dg6oj 134 36 . . . cord-104317-t30dg6oj 135 1 While while IN cord-104317-t30dg6oj 135 2 it -PRON- PRP cord-104317-t30dg6oj 135 3 is be VBZ cord-104317-t30dg6oj 135 4 known know VBN cord-104317-t30dg6oj 135 5 that that IN cord-104317-t30dg6oj 135 6 phages phage NNS cord-104317-t30dg6oj 135 7 can can MD cord-104317-t30dg6oj 135 8 be be VB cord-104317-t30dg6oj 135 9 co co VBN cord-104317-t30dg6oj 135 10 - - VBN cord-104317-t30dg6oj 135 11 opted opt VBN cord-104317-t30dg6oj 135 12 for for IN cord-104317-t30dg6oj 135 13 benefit benefit NN cord-104317-t30dg6oj 135 14 to to IN cord-104317-t30dg6oj 135 15 the the DT cord-104317-t30dg6oj 135 16 host host NN cord-104317-t30dg6oj 135 17 [ [ -LRB- cord-104317-t30dg6oj 135 18 66 66 CD cord-104317-t30dg6oj 135 19 ] ] -RRB- cord-104317-t30dg6oj 135 20 , , , cord-104317-t30dg6oj 135 21 I -PRON- PRP cord-104317-t30dg6oj 135 22 postulate postulate VBP cord-104317-t30dg6oj 135 23 that that IN cord-104317-t30dg6oj 135 24 the the DT cord-104317-t30dg6oj 135 25 presence presence NN cord-104317-t30dg6oj 135 26 of of IN cord-104317-t30dg6oj 135 27 this this DT cord-104317-t30dg6oj 135 28 amount amount NN cord-104317-t30dg6oj 135 29 of of IN cord-104317-t30dg6oj 135 30 genomic genomic JJ cord-104317-t30dg6oj 135 31 and and CC cord-104317-t30dg6oj 135 32 proteinaceous proteinaceous JJ cord-104317-t30dg6oj 135 33 material material NN cord-104317-t30dg6oj 135 34 is be VBZ cord-104317-t30dg6oj 135 35 unlikely unlikely JJ cord-104317-t30dg6oj 135 36 to to TO cord-104317-t30dg6oj 135 37 be be VB cord-104317-t30dg6oj 135 38 immunologically immunologically RB cord-104317-t30dg6oj 135 39 inert inert JJ cord-104317-t30dg6oj 135 40 . . . cord-104317-t30dg6oj 136 1 An an DT cord-104317-t30dg6oj 136 2 example example NN cord-104317-t30dg6oj 136 3 of of IN cord-104317-t30dg6oj 136 4 how how WRB cord-104317-t30dg6oj 136 5 a a DT cord-104317-t30dg6oj 136 6 phage phage NN cord-104317-t30dg6oj 136 7 could could MD cord-104317-t30dg6oj 136 8 affect affect VB cord-104317-t30dg6oj 136 9 human human JJ cord-104317-t30dg6oj 136 10 health health NN cord-104317-t30dg6oj 136 11 is be VBZ cord-104317-t30dg6oj 136 12 as as IN cord-104317-t30dg6oj 136 13 an an DT cord-104317-t30dg6oj 136 14 endogenous endogenous JJ cord-104317-t30dg6oj 136 15 ligand ligand NN cord-104317-t30dg6oj 136 16 for for IN cord-104317-t30dg6oj 136 17 immune immune JJ cord-104317-t30dg6oj 136 18 activation activation NN cord-104317-t30dg6oj 136 19 . . . cord-104317-t30dg6oj 137 1 It -PRON- PRP cord-104317-t30dg6oj 137 2 is be VBZ cord-104317-t30dg6oj 137 3 known know VBN cord-104317-t30dg6oj 137 4 that that IN cord-104317-t30dg6oj 137 5 humans human NNS cord-104317-t30dg6oj 137 6 harbor harbor VBP cord-104317-t30dg6oj 137 7 antibodies antibody NNS cord-104317-t30dg6oj 137 8 to to TO cord-104317-t30dg6oj 137 9 phage phage NN cord-104317-t30dg6oj 137 10 proteins protein NNS cord-104317-t30dg6oj 137 11 [ [ -LRB- cord-104317-t30dg6oj 137 12 67 67 CD cord-104317-t30dg6oj 137 13 ] ] -RRB- cord-104317-t30dg6oj 138 1 [ [ -LRB- cord-104317-t30dg6oj 138 2 68 68 CD cord-104317-t30dg6oj 138 3 ] ] -RRB- cord-104317-t30dg6oj 138 4 [ [ -LRB- cord-104317-t30dg6oj 138 5 69 69 CD cord-104317-t30dg6oj 138 6 ] ] -RRB- cord-104317-t30dg6oj 139 1 [ [ -LRB- cord-104317-t30dg6oj 139 2 70 70 CD cord-104317-t30dg6oj 139 3 ] ] -RRB- cord-104317-t30dg6oj 139 4 and and CC cord-104317-t30dg6oj 139 5 that that IN cord-104317-t30dg6oj 139 6 phagocytic phagocytic JJ cord-104317-t30dg6oj 139 7 cells cell NNS cord-104317-t30dg6oj 139 8 of of IN cord-104317-t30dg6oj 139 9 the the DT cord-104317-t30dg6oj 139 10 immune immune JJ cord-104317-t30dg6oj 139 11 system system NN cord-104317-t30dg6oj 139 12 can can MD cord-104317-t30dg6oj 139 13 ingest ingest VB cord-104317-t30dg6oj 139 14 phages phage NNS cord-104317-t30dg6oj 139 15 [ [ -LRB- cord-104317-t30dg6oj 139 16 71 71 CD cord-104317-t30dg6oj 139 17 ] ] -RRB- cord-104317-t30dg6oj 139 18 , , . cord-104317-t30dg6oj 140 1 but but CC cord-104317-t30dg6oj 140 2 whether whether IN cord-104317-t30dg6oj 140 3 this this DT cord-104317-t30dg6oj 140 4 has have VBZ cord-104317-t30dg6oj 140 5 any any DT cord-104317-t30dg6oj 140 6 negative negative JJ cord-104317-t30dg6oj 140 7 impact impact NN cord-104317-t30dg6oj 140 8 on on IN cord-104317-t30dg6oj 140 9 health health NN cord-104317-t30dg6oj 140 10 is be VBZ cord-104317-t30dg6oj 140 11 unknown unknown JJ cord-104317-t30dg6oj 140 12 . . . cord-104317-t30dg6oj 141 1 Toll toll NN cord-104317-t30dg6oj 141 2 - - HYPH cord-104317-t30dg6oj 141 3 like like JJ cord-104317-t30dg6oj 141 4 Receptors receptor NNS cord-104317-t30dg6oj 141 5 ( ( -LRB- cord-104317-t30dg6oj 141 6 TLRs TLRs NNP cord-104317-t30dg6oj 141 7 ) ) -RRB- cord-104317-t30dg6oj 141 8 -7 -7 . cord-104317-t30dg6oj 142 1 and and CC cord-104317-t30dg6oj 142 2 -9 -9 NN cord-104317-t30dg6oj 142 3 play play VBP cord-104317-t30dg6oj 142 4 key key JJ cord-104317-t30dg6oj 142 5 roles role NNS cord-104317-t30dg6oj 142 6 in in IN cord-104317-t30dg6oj 142 7 the the DT cord-104317-t30dg6oj 142 8 production production NN cord-104317-t30dg6oj 142 9 of of IN cord-104317-t30dg6oj 142 10 autoantibodies autoantibody NNS cord-104317-t30dg6oj 142 11 , , , cord-104317-t30dg6oj 142 12 presumably presumably RB cord-104317-t30dg6oj 142 13 via via IN cord-104317-t30dg6oj 142 14 sensing sensing NN cord-104317-t30dg6oj 142 15 of of IN cord-104317-t30dg6oj 142 16 nucleic nucleic JJ cord-104317-t30dg6oj 142 17 acid acid NN cord-104317-t30dg6oj 142 18 containing contain VBG cord-104317-t30dg6oj 142 19 immune immune JJ cord-104317-t30dg6oj 142 20 complexes complex NNS cord-104317-t30dg6oj 142 21 ( ( -LRB- cord-104317-t30dg6oj 142 22 reviewed review VBN cord-104317-t30dg6oj 142 23 in in IN cord-104317-t30dg6oj 142 24 [ [ -LRB- cord-104317-t30dg6oj 142 25 72 72 CD cord-104317-t30dg6oj 142 26 ] ] -RRB- cord-104317-t30dg6oj 142 27 ) ) -RRB- cord-104317-t30dg6oj 142 28 . . . cord-104317-t30dg6oj 143 1 These these DT cord-104317-t30dg6oj 143 2 autoantibodies autoantibody NNS cord-104317-t30dg6oj 143 3 could could MD cord-104317-t30dg6oj 143 4 be be VB cord-104317-t30dg6oj 143 5 derived derive VBN cord-104317-t30dg6oj 143 6 from from IN cord-104317-t30dg6oj 143 7 any any DT cord-104317-t30dg6oj 143 8 number number NN cord-104317-t30dg6oj 143 9 of of IN cord-104317-t30dg6oj 143 10 endogenous endogenous JJ cord-104317-t30dg6oj 143 11 sources source NNS cord-104317-t30dg6oj 143 12 , , , cord-104317-t30dg6oj 143 13 including include VBG cord-104317-t30dg6oj 143 14 those those DT cord-104317-t30dg6oj 143 15 of of IN cord-104317-t30dg6oj 143 16 phages phage NNS cord-104317-t30dg6oj 143 17 . . . cord-104317-t30dg6oj 144 1 Interestingly interestingly RB cord-104317-t30dg6oj 144 2 , , , cord-104317-t30dg6oj 144 3 identifying identify VBG cord-104317-t30dg6oj 144 4 the the DT cord-104317-t30dg6oj 144 5 particular particular JJ cord-104317-t30dg6oj 144 6 nucleic nucleic JJ cord-104317-t30dg6oj 144 7 acids acid NNS cord-104317-t30dg6oj 144 8 responsible responsible JJ cord-104317-t30dg6oj 144 9 for for IN cord-104317-t30dg6oj 144 10 this this DT cord-104317-t30dg6oj 144 11 activation activation NN cord-104317-t30dg6oj 144 12 in in IN cord-104317-t30dg6oj 144 13 vivo vivo NN cord-104317-t30dg6oj 144 14 has have VBZ cord-104317-t30dg6oj 144 15 been be VBN cord-104317-t30dg6oj 144 16 challenging challenge VBG cord-104317-t30dg6oj 144 17 , , , cord-104317-t30dg6oj 144 18 though though IN cord-104317-t30dg6oj 144 19 functional functional JJ cord-104317-t30dg6oj 144 20 work work NN cord-104317-t30dg6oj 144 21 has have VBZ cord-104317-t30dg6oj 144 22 vetted vet VBN cord-104317-t30dg6oj 144 23 this this DT cord-104317-t30dg6oj 144 24 mechanism mechanism NN cord-104317-t30dg6oj 144 25 with with IN cord-104317-t30dg6oj 144 26 immune immune JJ cord-104317-t30dg6oj 144 27 complexes complex NNS cord-104317-t30dg6oj 144 28 containing contain VBG cord-104317-t30dg6oj 144 29 nucleic nucleic JJ cord-104317-t30dg6oj 144 30 acids acid NNS cord-104317-t30dg6oj 144 31 [ [ -LRB- cord-104317-t30dg6oj 144 32 73 73 CD cord-104317-t30dg6oj 144 33 , , , cord-104317-t30dg6oj 144 34 74 74 CD cord-104317-t30dg6oj 144 35 ] ] -RRB- cord-104317-t30dg6oj 144 36 . . . cord-104317-t30dg6oj 145 1 It -PRON- PRP cord-104317-t30dg6oj 145 2 is be VBZ cord-104317-t30dg6oj 145 3 possible possible JJ cord-104317-t30dg6oj 145 4 that that IN cord-104317-t30dg6oj 145 5 B b NN cord-104317-t30dg6oj 145 6 - - HYPH cord-104317-t30dg6oj 145 7 cell cell NN cord-104317-t30dg6oj 145 8 Receptor receptor NN cord-104317-t30dg6oj 145 9 ( ( -LRB- cord-104317-t30dg6oj 145 10 BCR)-mediated bcr)-mediate VBN cord-104317-t30dg6oj 145 11 endocytic endocytic JJ cord-104317-t30dg6oj 145 12 or or CC cord-104317-t30dg6oj 145 13 plasmacytoid plasmacytoid JJ cord-104317-t30dg6oj 145 14 dendritic dendritic JJ cord-104317-t30dg6oj 145 15 cell cell NN cord-104317-t30dg6oj 145 16 ( ( -LRB- cord-104317-t30dg6oj 145 17 pDC pDC NNP cord-104317-t30dg6oj 145 18 ) ) -RRB- cord-104317-t30dg6oj 145 19 phagocytic phagocytic JJ cord-104317-t30dg6oj 145 20 internalization internalization NN cord-104317-t30dg6oj 145 21 of of IN cord-104317-t30dg6oj 145 22 phages phage NNS cord-104317-t30dg6oj 145 23 could could MD cord-104317-t30dg6oj 145 24 deliver deliver VB cord-104317-t30dg6oj 145 25 ligands ligand NNS cord-104317-t30dg6oj 145 26 necessary necessary JJ cord-104317-t30dg6oj 145 27 for for IN cord-104317-t30dg6oj 145 28 these these DT cord-104317-t30dg6oj 145 29 responses response NNS cord-104317-t30dg6oj 145 30 . . . cord-104317-t30dg6oj 146 1 In in IN cord-104317-t30dg6oj 146 2 this this DT cord-104317-t30dg6oj 146 3 light light NN cord-104317-t30dg6oj 146 4 , , , cord-104317-t30dg6oj 146 5 I -PRON- PRP cord-104317-t30dg6oj 146 6 would would MD cord-104317-t30dg6oj 146 7 argue argue VB cord-104317-t30dg6oj 146 8 that that IN cord-104317-t30dg6oj 146 9 correlating correlate VBG cord-104317-t30dg6oj 146 10 phage phage NN cord-104317-t30dg6oj 146 11 localization localization NN cord-104317-t30dg6oj 146 12 and and CC cord-104317-t30dg6oj 146 13 expression expression NN cord-104317-t30dg6oj 146 14 with with IN cord-104317-t30dg6oj 146 15 disease disease NN cord-104317-t30dg6oj 146 16 state state NN cord-104317-t30dg6oj 146 17 is be VBZ cord-104317-t30dg6oj 146 18 a a DT cord-104317-t30dg6oj 146 19 particularly particularly RB cord-104317-t30dg6oj 146 20 intriguing intriguing JJ cord-104317-t30dg6oj 146 21 area area NN cord-104317-t30dg6oj 146 22 of of IN cord-104317-t30dg6oj 146 23 research research NN cord-104317-t30dg6oj 146 24 moving move VBG cord-104317-t30dg6oj 146 25 forward forward RB cord-104317-t30dg6oj 146 26 . . . cord-104317-t30dg6oj 147 1 Such such JJ cord-104317-t30dg6oj 147 2 research research NN cord-104317-t30dg6oj 147 3 may may MD cord-104317-t30dg6oj 147 4 also also RB cord-104317-t30dg6oj 147 5 elucidate elucidate VB cord-104317-t30dg6oj 147 6 mechanisms mechanism NNS cord-104317-t30dg6oj 147 7 by by IN cord-104317-t30dg6oj 147 8 which which WDT cord-104317-t30dg6oj 147 9 specific specific JJ cord-104317-t30dg6oj 147 10 bacteria bacteria NNS cord-104317-t30dg6oj 147 11 ( ( -LRB- cord-104317-t30dg6oj 147 12 and and CC cord-104317-t30dg6oj 147 13 their -PRON- PRP$ cord-104317-t30dg6oj 147 14 viral viral JJ cord-104317-t30dg6oj 147 15 cargo cargo NN cord-104317-t30dg6oj 147 16 ) ) -RRB- cord-104317-t30dg6oj 147 17 are be VBP cord-104317-t30dg6oj 147 18 linked link VBN cord-104317-t30dg6oj 147 19 to to IN cord-104317-t30dg6oj 147 20 autoimmune autoimmune JJ cord-104317-t30dg6oj 147 21 , , , cord-104317-t30dg6oj 147 22 allergic allergic JJ cord-104317-t30dg6oj 147 23 , , , cord-104317-t30dg6oj 147 24 and and CC cord-104317-t30dg6oj 147 25 pathogenic pathogenic JJ cord-104317-t30dg6oj 147 26 phenotypes phenotype NNS cord-104317-t30dg6oj 147 27 . . . cord-104317-t30dg6oj 148 1 Protozoan protozoan NN cord-104317-t30dg6oj 148 2 parasite parasite NN cord-104317-t30dg6oj 148 3 - - HYPH cord-104317-t30dg6oj 148 4 associated associate VBN cord-104317-t30dg6oj 148 5 viruses virus NNS cord-104317-t30dg6oj 148 6 have have VBP cord-104317-t30dg6oj 148 7 emerged emerge VBN cord-104317-t30dg6oj 148 8 as as IN cord-104317-t30dg6oj 148 9 another another DT cord-104317-t30dg6oj 148 10 source source NN cord-104317-t30dg6oj 148 11 of of IN cord-104317-t30dg6oj 148 12 atypically atypically RB cord-104317-t30dg6oj 148 13 pathogenic pathogenic JJ cord-104317-t30dg6oj 148 14 effects effect NNS cord-104317-t30dg6oj 148 15 in in IN cord-104317-t30dg6oj 148 16 humans human NNS cord-104317-t30dg6oj 148 17 [ [ -LRB- cord-104317-t30dg6oj 148 18 75 75 CD cord-104317-t30dg6oj 148 19 ] ] -RRB- cord-104317-t30dg6oj 148 20 . . . cord-104317-t30dg6oj 149 1 Such such JJ cord-104317-t30dg6oj 149 2 interactions interaction NNS cord-104317-t30dg6oj 149 3 are be VBP cord-104317-t30dg6oj 149 4 reminiscent reminiscent JJ cord-104317-t30dg6oj 149 5 of of IN cord-104317-t30dg6oj 149 6 the the DT cord-104317-t30dg6oj 149 7 uses use NNS cord-104317-t30dg6oj 149 8 of of IN cord-104317-t30dg6oj 149 9 viruses virus NNS cord-104317-t30dg6oj 149 10 as as IN cord-104317-t30dg6oj 149 11 agents agent NNS cord-104317-t30dg6oj 149 12 for for IN cord-104317-t30dg6oj 149 13 forwarding forward VBG cord-104317-t30dg6oj 149 14 their -PRON- PRP$ cord-104317-t30dg6oj 149 15 host host NN cord-104317-t30dg6oj 149 16 's 's POS cord-104317-t30dg6oj 149 17 survival survival NN cord-104317-t30dg6oj 149 18 in in IN cord-104317-t30dg6oj 149 19 parasitoid parasitoid NN cord-104317-t30dg6oj 149 20 wasps wasp NNS cord-104317-t30dg6oj 149 21 and and CC cord-104317-t30dg6oj 149 22 plants plant NNS cord-104317-t30dg6oj 149 23 ( ( -LRB- cord-104317-t30dg6oj 149 24 see see VB cord-104317-t30dg6oj 149 25 An an DT cord-104317-t30dg6oj 149 26 Ecological Ecological NNP cord-104317-t30dg6oj 149 27 Framework Framework NNP cord-104317-t30dg6oj 149 28 of of IN cord-104317-t30dg6oj 149 29 the the DT cord-104317-t30dg6oj 149 30 Human Human NNP cord-104317-t30dg6oj 149 31 Virome Virome NNP cord-104317-t30dg6oj 149 32 , , , cord-104317-t30dg6oj 149 33 above above RB cord-104317-t30dg6oj 149 34 ) ) -RRB- cord-104317-t30dg6oj 149 35 . . . cord-104317-t30dg6oj 150 1 The the DT cord-104317-t30dg6oj 150 2 recognition recognition NN cord-104317-t30dg6oj 150 3 of of IN cord-104317-t30dg6oj 150 4 the the DT cord-104317-t30dg6oj 150 5 Leishmania Leishmania NNP cord-104317-t30dg6oj 150 6 - - HYPH cord-104317-t30dg6oj 150 7 infecting infect VBG cord-104317-t30dg6oj 150 8 LRV1 LRV1 NNP cord-104317-t30dg6oj 150 9 virus virus NN cord-104317-t30dg6oj 150 10 by by IN cord-104317-t30dg6oj 150 11 human human JJ cord-104317-t30dg6oj 150 12 macrophages macrophage NNS cord-104317-t30dg6oj 150 13 can can MD cord-104317-t30dg6oj 150 14 promote promote VB cord-104317-t30dg6oj 150 15 inflammation inflammation NN cord-104317-t30dg6oj 150 16 , , , cord-104317-t30dg6oj 150 17 subvert subvert VB cord-104317-t30dg6oj 150 18 the the DT cord-104317-t30dg6oj 150 19 immune immune JJ cord-104317-t30dg6oj 150 20 response response NN cord-104317-t30dg6oj 150 21 , , , cord-104317-t30dg6oj 150 22 and and CC cord-104317-t30dg6oj 150 23 ultimately ultimately RB cord-104317-t30dg6oj 150 24 promote promote VB cord-104317-t30dg6oj 150 25 persistence persistence NN cord-104317-t30dg6oj 150 26 of of IN cord-104317-t30dg6oj 150 27 the the DT cord-104317-t30dg6oj 150 28 parasite parasite NN cord-104317-t30dg6oj 150 29 [ [ -LRB- cord-104317-t30dg6oj 150 30 76 76 CD cord-104317-t30dg6oj 150 31 ] ] -RRB- cord-104317-t30dg6oj 150 32 . . . cord-104317-t30dg6oj 151 1 Trichomonas Trichomonas NNP cord-104317-t30dg6oj 151 2 vaginalis vaginalis NN cord-104317-t30dg6oj 151 3 harbors harbor VBZ cord-104317-t30dg6oj 151 4 a a DT cord-104317-t30dg6oj 151 5 Trichomonasvirus Trichomonasvirus NNP cord-104317-t30dg6oj 151 6 that that WDT cord-104317-t30dg6oj 151 7 triggers trigger VBZ cord-104317-t30dg6oj 151 8 IFN IFN NNP cord-104317-t30dg6oj 151 9 responses response NNS cord-104317-t30dg6oj 151 10 via via IN cord-104317-t30dg6oj 151 11 TLR-3 TLR-3 NNP cord-104317-t30dg6oj 151 12 , , , cord-104317-t30dg6oj 151 13 leading lead VBG cord-104317-t30dg6oj 151 14 to to IN cord-104317-t30dg6oj 151 15 inflammatory inflammatory JJ cord-104317-t30dg6oj 151 16 sequelae sequela NNS cord-104317-t30dg6oj 151 17 [ [ -LRB- cord-104317-t30dg6oj 151 18 77 77 CD cord-104317-t30dg6oj 151 19 ] ] -RRB- cord-104317-t30dg6oj 151 20 . . . cord-104317-t30dg6oj 152 1 At at IN cord-104317-t30dg6oj 152 2 present present JJ cord-104317-t30dg6oj 152 3 , , , cord-104317-t30dg6oj 152 4 there there EX cord-104317-t30dg6oj 152 5 is be VBZ cord-104317-t30dg6oj 152 6 insufficient insufficient JJ cord-104317-t30dg6oj 152 7 data datum NNS cord-104317-t30dg6oj 152 8 as as IN cord-104317-t30dg6oj 152 9 to to IN cord-104317-t30dg6oj 152 10 whether whether IN cord-104317-t30dg6oj 152 11 these these DT cord-104317-t30dg6oj 152 12 are be VBP cord-104317-t30dg6oj 152 13 evolutionarily evolutionarily RB cord-104317-t30dg6oj 152 14 adapted adapt VBN cord-104317-t30dg6oj 152 15 mechanisms mechanism NNS cord-104317-t30dg6oj 152 16 meant mean VBN cord-104317-t30dg6oj 152 17 to to TO cord-104317-t30dg6oj 152 18 perturb perturb VB cord-104317-t30dg6oj 152 19 host host NN cord-104317-t30dg6oj 152 20 immunity immunity NN cord-104317-t30dg6oj 152 21 to to TO cord-104317-t30dg6oj 152 22 benefit benefit VB cord-104317-t30dg6oj 152 23 the the DT cord-104317-t30dg6oj 152 24 parasite parasite NN cord-104317-t30dg6oj 152 25 , , , cord-104317-t30dg6oj 152 26 but but CC cord-104317-t30dg6oj 152 27 the the DT cord-104317-t30dg6oj 152 28 extensive extensive JJ cord-104317-t30dg6oj 152 29 literature literature NN cord-104317-t30dg6oj 152 30 of of IN cord-104317-t30dg6oj 152 31 such such JJ cord-104317-t30dg6oj 152 32 interaction interaction NN cord-104317-t30dg6oj 152 33 in in IN cord-104317-t30dg6oj 152 34 insects insect NNS cord-104317-t30dg6oj 152 35 and and CC cord-104317-t30dg6oj 152 36 plants plant NNS cord-104317-t30dg6oj 152 37 makes make VBZ cord-104317-t30dg6oj 152 38 this this DT cord-104317-t30dg6oj 152 39 a a DT cord-104317-t30dg6oj 152 40 tantalizing tantalize VBG cord-104317-t30dg6oj 152 41 conjecture conjecture NN cord-104317-t30dg6oj 152 42 . . . cord-104317-t30dg6oj 153 1 Additional additional JJ cord-104317-t30dg6oj 153 2 characterization characterization NN cord-104317-t30dg6oj 153 3 should should MD cord-104317-t30dg6oj 153 4 explore explore VB cord-104317-t30dg6oj 153 5 the the DT cord-104317-t30dg6oj 153 6 nature nature NN cord-104317-t30dg6oj 153 7 of of IN cord-104317-t30dg6oj 153 8 the the DT cord-104317-t30dg6oj 153 9 interactions interaction NNS cord-104317-t30dg6oj 153 10 of of IN cord-104317-t30dg6oj 153 11 protozoan protozoan NN cord-104317-t30dg6oj 153 12 viruses virus NNS cord-104317-t30dg6oj 153 13 with with IN cord-104317-t30dg6oj 153 14 humans human NNS cord-104317-t30dg6oj 153 15 . . . cord-104317-t30dg6oj 154 1 While while IN cord-104317-t30dg6oj 154 2 all all PDT cord-104317-t30dg6oj 154 3 the the DT cord-104317-t30dg6oj 154 4 above above JJ cord-104317-t30dg6oj 154 5 postulates postulate NNS cord-104317-t30dg6oj 154 6 are be VBP cord-104317-t30dg6oj 154 7 conjecture conjecture JJ cord-104317-t30dg6oj 154 8 on on IN cord-104317-t30dg6oj 154 9 the the DT cord-104317-t30dg6oj 154 10 limited limited JJ cord-104317-t30dg6oj 154 11 knowledge knowledge NN cord-104317-t30dg6oj 154 12 base base NN cord-104317-t30dg6oj 154 13 regarding regard VBG cord-104317-t30dg6oj 154 14 atypically atypically RB cord-104317-t30dg6oj 154 15 pathogenic pathogenic JJ cord-104317-t30dg6oj 154 16 virus virus NN cord-104317-t30dg6oj 154 17 - - HYPH cord-104317-t30dg6oj 154 18 host host NN cord-104317-t30dg6oj 154 19 interactions interaction NNS cord-104317-t30dg6oj 154 20 , , , cord-104317-t30dg6oj 154 21 it -PRON- PRP cord-104317-t30dg6oj 154 22 must must MD cord-104317-t30dg6oj 154 23 be be VB cord-104317-t30dg6oj 154 24 noted note VBN cord-104317-t30dg6oj 154 25 that that IN cord-104317-t30dg6oj 154 26 these these DT cord-104317-t30dg6oj 154 27 are be VBP cord-104317-t30dg6oj 154 28 certainly certainly RB cord-104317-t30dg6oj 154 29 not not RB cord-104317-t30dg6oj 154 30 overlying overlying JJ cord-104317-t30dg6oj 154 31 principles principle NNS cord-104317-t30dg6oj 154 32 . . . cord-104317-t30dg6oj 155 1 Associated associated JJ cord-104317-t30dg6oj 155 2 pathologies pathology NNS cord-104317-t30dg6oj 155 3 likely likely RB cord-104317-t30dg6oj 155 4 require require VBP cord-104317-t30dg6oj 155 5 particular particular JJ cord-104317-t30dg6oj 155 6 genetic genetic JJ cord-104317-t30dg6oj 155 7 dispositions disposition NNS cord-104317-t30dg6oj 155 8 and/or and/or CC cord-104317-t30dg6oj 155 9 external external JJ cord-104317-t30dg6oj 155 10 stressor stressor NN cord-104317-t30dg6oj 155 11 states state NNS cord-104317-t30dg6oj 155 12 . . . cord-104317-t30dg6oj 156 1 It -PRON- PRP cord-104317-t30dg6oj 156 2 can can MD cord-104317-t30dg6oj 156 3 not not RB cord-104317-t30dg6oj 156 4 be be VB cord-104317-t30dg6oj 156 5 understated understate VBN cord-104317-t30dg6oj 156 6 , , , cord-104317-t30dg6oj 156 7 however however RB cord-104317-t30dg6oj 156 8 , , , cord-104317-t30dg6oj 156 9 that that IN cord-104317-t30dg6oj 156 10 a a DT cord-104317-t30dg6oj 156 11 better well JJR cord-104317-t30dg6oj 156 12 understanding understanding NN cord-104317-t30dg6oj 156 13 of of IN cord-104317-t30dg6oj 156 14 the the DT cord-104317-t30dg6oj 156 15 viruses virus NNS cord-104317-t30dg6oj 156 16 that that WDT cord-104317-t30dg6oj 156 17 typically typically RB cord-104317-t30dg6oj 156 18 inhabit inhabit VBP cord-104317-t30dg6oj 156 19 humans human NNS cord-104317-t30dg6oj 156 20 will will MD cord-104317-t30dg6oj 156 21 likely likely RB cord-104317-t30dg6oj 156 22 lead lead VB cord-104317-t30dg6oj 156 23 to to IN cord-104317-t30dg6oj 156 24 a a DT cord-104317-t30dg6oj 156 25 concomitant concomitant JJ cord-104317-t30dg6oj 156 26 rise rise NN cord-104317-t30dg6oj 156 27 in in IN cord-104317-t30dg6oj 156 28 the the DT cord-104317-t30dg6oj 156 29 cases case NNS cord-104317-t30dg6oj 156 30 of of IN cord-104317-t30dg6oj 156 31 viruses virus NNS cord-104317-t30dg6oj 156 32 identified identify VBN cord-104317-t30dg6oj 156 33 as as IN cord-104317-t30dg6oj 156 34 atypically atypically RB cord-104317-t30dg6oj 156 35 pathogenic pathogenic JJ cord-104317-t30dg6oj 156 36 . . . cord-104317-t30dg6oj 157 1 The the DT cord-104317-t30dg6oj 157 2 term term NN cord-104317-t30dg6oj 157 3 commensal commensal NN cord-104317-t30dg6oj 157 4 was be VBD cord-104317-t30dg6oj 157 5 originally originally RB cord-104317-t30dg6oj 157 6 coined coin VBN cord-104317-t30dg6oj 157 7 to to TO cord-104317-t30dg6oj 157 8 describe describe VB cord-104317-t30dg6oj 157 9 an an DT cord-104317-t30dg6oj 157 10 organism organism NN cord-104317-t30dg6oj 157 11 that that WDT cord-104317-t30dg6oj 157 12 benefitted benefit VBD cord-104317-t30dg6oj 157 13 from from IN cord-104317-t30dg6oj 157 14 being be VBG cord-104317-t30dg6oj 157 15 on on IN cord-104317-t30dg6oj 157 16 or or CC cord-104317-t30dg6oj 157 17 in in IN cord-104317-t30dg6oj 157 18 a a DT cord-104317-t30dg6oj 157 19 host host NN cord-104317-t30dg6oj 157 20 but but CC cord-104317-t30dg6oj 157 21 did do VBD cord-104317-t30dg6oj 157 22 not not RB cord-104317-t30dg6oj 157 23 have have VB cord-104317-t30dg6oj 157 24 any any DT cord-104317-t30dg6oj 157 25 direct direct JJ cord-104317-t30dg6oj 157 26 detriment detriment NN cord-104317-t30dg6oj 157 27 or or CC cord-104317-t30dg6oj 157 28 benefit benefit NN cord-104317-t30dg6oj 157 29 for for IN cord-104317-t30dg6oj 157 30 the the DT cord-104317-t30dg6oj 157 31 host host NN cord-104317-t30dg6oj 157 32 [ [ -LRB- cord-104317-t30dg6oj 157 33 78 78 CD cord-104317-t30dg6oj 157 34 ] ] -RRB- cord-104317-t30dg6oj 157 35 . . . cord-104317-t30dg6oj 158 1 As as IN cord-104317-t30dg6oj 158 2 the the DT cord-104317-t30dg6oj 158 3 field field NN cord-104317-t30dg6oj 158 4 of of IN cord-104317-t30dg6oj 158 5 microbiome microbiome NN cord-104317-t30dg6oj 158 6 research research NN cord-104317-t30dg6oj 158 7 blossomed blossom VBD cord-104317-t30dg6oj 158 8 , , , cord-104317-t30dg6oj 158 9 it -PRON- PRP cord-104317-t30dg6oj 158 10 became become VBD cord-104317-t30dg6oj 158 11 clear clear JJ cord-104317-t30dg6oj 158 12 that that IN cord-104317-t30dg6oj 158 13 many many JJ cord-104317-t30dg6oj 158 14 of of IN cord-104317-t30dg6oj 158 15 the the DT cord-104317-t30dg6oj 158 16 microbes microbe NNS cord-104317-t30dg6oj 158 17 that that WDT cord-104317-t30dg6oj 158 18 had have VBD cord-104317-t30dg6oj 158 19 originally originally RB cord-104317-t30dg6oj 158 20 been be VBN cord-104317-t30dg6oj 158 21 considered consider VBN cord-104317-t30dg6oj 158 22 commensal commensal NN cord-104317-t30dg6oj 158 23 truly truly RB cord-104317-t30dg6oj 158 24 did do VBD cord-104317-t30dg6oj 158 25 have have VB cord-104317-t30dg6oj 158 26 direct direct JJ cord-104317-t30dg6oj 158 27 effects effect NNS cord-104317-t30dg6oj 158 28 on on IN cord-104317-t30dg6oj 158 29 host host NN cord-104317-t30dg6oj 158 30 health health NN cord-104317-t30dg6oj 158 31 ( ( -LRB- cord-104317-t30dg6oj 158 32 reviewed review VBN cord-104317-t30dg6oj 158 33 in in IN cord-104317-t30dg6oj 158 34 [ [ -LRB- cord-104317-t30dg6oj 158 35 79 79 CD cord-104317-t30dg6oj 158 36 ] ] -RRB- cord-104317-t30dg6oj 158 37 ) ) -RRB- cord-104317-t30dg6oj 158 38 . . . cord-104317-t30dg6oj 159 1 These these DT cord-104317-t30dg6oj 159 2 organisms organism NNS cord-104317-t30dg6oj 159 3 may may MD cord-104317-t30dg6oj 159 4 be be VB cord-104317-t30dg6oj 159 5 more more RBR cord-104317-t30dg6oj 159 6 accurately accurately RB cord-104317-t30dg6oj 159 7 defined define VBN cord-104317-t30dg6oj 159 8 as as IN cord-104317-t30dg6oj 159 9 atypically atypically RB cord-104317-t30dg6oj 159 10 pathogenic pathogenic JJ cord-104317-t30dg6oj 159 11 or or CC cord-104317-t30dg6oj 159 12 mutualistic mutualistic JJ cord-104317-t30dg6oj 159 13 ( ( -LRB- cord-104317-t30dg6oj 159 14 see see VB cord-104317-t30dg6oj 159 15 sections section NNS cord-104317-t30dg6oj 159 16 above above RB cord-104317-t30dg6oj 159 17 and and CC cord-104317-t30dg6oj 159 18 below below RB cord-104317-t30dg6oj 159 19 , , , cord-104317-t30dg6oj 159 20 respectively respectively RB cord-104317-t30dg6oj 159 21 ) ) -RRB- cord-104317-t30dg6oj 159 22 if if IN cord-104317-t30dg6oj 159 23 these these DT cord-104317-t30dg6oj 159 24 effects effect NNS cord-104317-t30dg6oj 159 25 are be VBP cord-104317-t30dg6oj 159 26 common common JJ cord-104317-t30dg6oj 159 27 or or CC cord-104317-t30dg6oj 159 28 stable stable JJ cord-104317-t30dg6oj 159 29 , , , cord-104317-t30dg6oj 159 30 but but CC cord-104317-t30dg6oj 159 31 in in IN cord-104317-t30dg6oj 159 32 general general JJ cord-104317-t30dg6oj 159 33 , , , cord-104317-t30dg6oj 159 34 scientists scientist NNS cord-104317-t30dg6oj 159 35 have have VBP cord-104317-t30dg6oj 159 36 followed follow VBN cord-104317-t30dg6oj 159 37 the the DT cord-104317-t30dg6oj 159 38 practice practice NN cord-104317-t30dg6oj 159 39 of of IN cord-104317-t30dg6oj 159 40 innocence innocence NN cord-104317-t30dg6oj 159 41 until until IN cord-104317-t30dg6oj 159 42 proven prove VBN cord-104317-t30dg6oj 159 43 guilty guilty JJ cord-104317-t30dg6oj 159 44 . . . cord-104317-t30dg6oj 160 1 However however RB cord-104317-t30dg6oj 160 2 , , , cord-104317-t30dg6oj 160 3 it -PRON- PRP cord-104317-t30dg6oj 160 4 is be VBZ cord-104317-t30dg6oj 160 5 likely likely JJ cord-104317-t30dg6oj 160 6 that that IN cord-104317-t30dg6oj 160 7 many many JJ cord-104317-t30dg6oj 160 8 commensals commensal NNS cord-104317-t30dg6oj 160 9 exist exist VBP cord-104317-t30dg6oj 160 10 that that IN cord-104317-t30dg6oj 160 11 either either CC cord-104317-t30dg6oj 160 12 rarely rarely RB cord-104317-t30dg6oj 160 13 or or CC cord-104317-t30dg6oj 160 14 never never RB cord-104317-t30dg6oj 160 15 have have VB cord-104317-t30dg6oj 160 16 effects effect NNS cord-104317-t30dg6oj 160 17 on on IN cord-104317-t30dg6oj 160 18 the the DT cord-104317-t30dg6oj 160 19 host host NN cord-104317-t30dg6oj 160 20 . . . cord-104317-t30dg6oj 161 1 While while IN cord-104317-t30dg6oj 161 2 at at IN cord-104317-t30dg6oj 161 3 the the DT cord-104317-t30dg6oj 161 4 local local JJ cord-104317-t30dg6oj 161 5 level level NN cord-104317-t30dg6oj 161 6 some some DT cord-104317-t30dg6oj 161 7 commensal commensal JJ cord-104317-t30dg6oj 161 8 viruses virus NNS cord-104317-t30dg6oj 161 9 may may MD cord-104317-t30dg6oj 161 10 have have VB cord-104317-t30dg6oj 161 11 detrimental detrimental JJ cord-104317-t30dg6oj 161 12 effects effect NNS cord-104317-t30dg6oj 161 13 on on IN cord-104317-t30dg6oj 161 14 individual individual JJ cord-104317-t30dg6oj 161 15 cells cell NNS cord-104317-t30dg6oj 161 16 , , , cord-104317-t30dg6oj 161 17 many many JJ cord-104317-t30dg6oj 161 18 eukaryotic eukaryotic JJ cord-104317-t30dg6oj 161 19 and and CC cord-104317-t30dg6oj 161 20 prokaryotic prokaryotic JJ cord-104317-t30dg6oj 161 21 viruses virus NNS cord-104317-t30dg6oj 161 22 are be VBP cord-104317-t30dg6oj 161 23 associated associate VBN cord-104317-t30dg6oj 161 24 with with IN cord-104317-t30dg6oj 161 25 healthy healthy JJ cord-104317-t30dg6oj 161 26 human human JJ cord-104317-t30dg6oj 161 27 tissues tissue NNS cord-104317-t30dg6oj 161 28 [ [ -LRB- cord-104317-t30dg6oj 161 29 80 80 CD cord-104317-t30dg6oj 161 30 ] ] -RRB- cord-104317-t30dg6oj 162 1 [ [ -LRB- cord-104317-t30dg6oj 162 2 81 81 CD cord-104317-t30dg6oj 162 3 ] ] -RRB- cord-104317-t30dg6oj 163 1 [ [ -LRB- cord-104317-t30dg6oj 163 2 82 82 CD cord-104317-t30dg6oj 163 3 ] ] -RRB- cord-104317-t30dg6oj 164 1 [ [ -LRB- cord-104317-t30dg6oj 164 2 83 83 CD cord-104317-t30dg6oj 164 3 ] ] -RRB- cord-104317-t30dg6oj 165 1 [ [ -LRB- cord-104317-t30dg6oj 165 2 84 84 CD cord-104317-t30dg6oj 165 3 ] ] -RRB- cord-104317-t30dg6oj 165 4 [ [ -LRB- cord-104317-t30dg6oj 165 5 85 85 CD cord-104317-t30dg6oj 165 6 ] ] -RRB- cord-104317-t30dg6oj 165 7 [ [ -LRB- cord-104317-t30dg6oj 165 8 86 86 CD cord-104317-t30dg6oj 165 9 ] ] -RRB- cord-104317-t30dg6oj 165 10 [ [ -LRB- cord-104317-t30dg6oj 165 11 87 87 CD cord-104317-t30dg6oj 165 12 ] ] -RRB- cord-104317-t30dg6oj 165 13 . . . cord-104317-t30dg6oj 166 1 The the DT cord-104317-t30dg6oj 166 2 prototypical prototypical JJ cord-104317-t30dg6oj 166 3 examples example NNS cord-104317-t30dg6oj 166 4 of of IN cord-104317-t30dg6oj 166 5 commensal commensal JJ cord-104317-t30dg6oj 166 6 viruses virus NNS cord-104317-t30dg6oj 166 7 are be VBP cord-104317-t30dg6oj 166 8 phages phage NNS cord-104317-t30dg6oj 166 9 that that WDT cord-104317-t30dg6oj 166 10 infect infect VBP cord-104317-t30dg6oj 166 11 bacteria bacteria NNS cord-104317-t30dg6oj 166 12 [ [ -LRB- cord-104317-t30dg6oj 166 13 88 88 CD cord-104317-t30dg6oj 166 14 ] ] -RRB- cord-104317-t30dg6oj 166 15 . . . cord-104317-t30dg6oj 167 1 No no DT cord-104317-t30dg6oj 167 2 phages phage NNS cord-104317-t30dg6oj 167 3 are be VBP cord-104317-t30dg6oj 167 4 known know VBN cord-104317-t30dg6oj 167 5 to to TO cord-104317-t30dg6oj 167 6 infect infect VB cord-104317-t30dg6oj 167 7 human human JJ cord-104317-t30dg6oj 167 8 cells cell NNS cord-104317-t30dg6oj 167 9 and and CC cord-104317-t30dg6oj 167 10 therefore therefore RB cord-104317-t30dg6oj 167 11 their -PRON- PRP$ cord-104317-t30dg6oj 167 12 presence presence NN cord-104317-t30dg6oj 167 13 may may MD cord-104317-t30dg6oj 167 14 be be VB cord-104317-t30dg6oj 167 15 primarily primarily RB cord-104317-t30dg6oj 167 16 innocuous innocuous JJ cord-104317-t30dg6oj 167 17 . . . cord-104317-t30dg6oj 168 1 The the DT cord-104317-t30dg6oj 168 2 effect effect NN cord-104317-t30dg6oj 168 3 of of IN cord-104317-t30dg6oj 168 4 phages phage NNS cord-104317-t30dg6oj 168 5 on on IN cord-104317-t30dg6oj 168 6 the the DT cord-104317-t30dg6oj 168 7 composition composition NN cord-104317-t30dg6oj 168 8 of of IN cord-104317-t30dg6oj 168 9 the the DT cord-104317-t30dg6oj 168 10 microbiome microbiome NN cord-104317-t30dg6oj 168 11 , , , cord-104317-t30dg6oj 168 12 in in IN cord-104317-t30dg6oj 168 13 that that IN cord-104317-t30dg6oj 168 14 they -PRON- PRP cord-104317-t30dg6oj 168 15 may may MD cord-104317-t30dg6oj 168 16 kill kill VB cord-104317-t30dg6oj 168 17 or or CC cord-104317-t30dg6oj 168 18 inhibit inhibit VB cord-104317-t30dg6oj 168 19 growth growth NN cord-104317-t30dg6oj 168 20 of of IN cord-104317-t30dg6oj 168 21 some some DT cord-104317-t30dg6oj 168 22 bacteria bacteria NNS cord-104317-t30dg6oj 168 23 , , , cord-104317-t30dg6oj 168 24 could could MD cord-104317-t30dg6oj 168 25 be be VB cord-104317-t30dg6oj 168 26 considered consider VBN cord-104317-t30dg6oj 168 27 a a DT cord-104317-t30dg6oj 168 28 possible possible JJ cord-104317-t30dg6oj 168 29 detriment detriment NN cord-104317-t30dg6oj 168 30 or or CC cord-104317-t30dg6oj 168 31 benefit benefit NN cord-104317-t30dg6oj 168 32 depending depend VBG cord-104317-t30dg6oj 168 33 on on IN cord-104317-t30dg6oj 168 34 the the DT cord-104317-t30dg6oj 168 35 situation situation NN cord-104317-t30dg6oj 168 36 , , , cord-104317-t30dg6oj 168 37 albeit albeit IN cord-104317-t30dg6oj 168 38 indirect indirect JJ cord-104317-t30dg6oj 168 39 . . . cord-104317-t30dg6oj 169 1 In in IN cord-104317-t30dg6oj 169 2 fact fact NN cord-104317-t30dg6oj 169 3 , , , cord-104317-t30dg6oj 169 4 the the DT cord-104317-t30dg6oj 169 5 targeted target VBN cord-104317-t30dg6oj 169 6 utilization utilization NN cord-104317-t30dg6oj 169 7 of of IN cord-104317-t30dg6oj 169 8 phages phage NNS cord-104317-t30dg6oj 169 9 to to TO cord-104317-t30dg6oj 169 10 eliminate eliminate VB cord-104317-t30dg6oj 169 11 unwanted unwanted JJ cord-104317-t30dg6oj 169 12 bacterial bacterial JJ cord-104317-t30dg6oj 169 13 pathogens pathogen NNS cord-104317-t30dg6oj 169 14 ( ( -LRB- cord-104317-t30dg6oj 169 15 phage phage NN cord-104317-t30dg6oj 169 16 therapy therapy NN cord-104317-t30dg6oj 169 17 ) ) -RRB- cord-104317-t30dg6oj 169 18 was be VBD cord-104317-t30dg6oj 169 19 introduced introduce VBN cord-104317-t30dg6oj 169 20 in in IN cord-104317-t30dg6oj 169 21 the the DT cord-104317-t30dg6oj 169 22 early early JJ cord-104317-t30dg6oj 169 23 1900s 1900 NNS cord-104317-t30dg6oj 169 24 and and CC cord-104317-t30dg6oj 169 25 has have VBZ cord-104317-t30dg6oj 169 26 many many JJ cord-104317-t30dg6oj 169 27 potential potential JJ cord-104317-t30dg6oj 169 28 benefits benefit NNS cord-104317-t30dg6oj 169 29 including include VBG cord-104317-t30dg6oj 169 30 , , , cord-104317-t30dg6oj 169 31 but but CC cord-104317-t30dg6oj 169 32 not not RB cord-104317-t30dg6oj 169 33 limited limited JJ cord-104317-t30dg6oj 169 34 to to IN cord-104317-t30dg6oj 169 35 , , , cord-104317-t30dg6oj 169 36 low low JJ cord-104317-t30dg6oj 169 37 toxicity toxicity NN cord-104317-t30dg6oj 169 38 , , , cord-104317-t30dg6oj 169 39 treatment treatment NN cord-104317-t30dg6oj 169 40 of of IN cord-104317-t30dg6oj 169 41 antibiotic antibiotic JJ cord-104317-t30dg6oj 169 42 resistant resistant JJ cord-104317-t30dg6oj 169 43 infections infection NNS cord-104317-t30dg6oj 169 44 , , , cord-104317-t30dg6oj 169 45 and and CC cord-104317-t30dg6oj 169 46 rapid rapid JJ cord-104317-t30dg6oj 169 47 discovery discovery NN cord-104317-t30dg6oj 169 48 / / SYM cord-104317-t30dg6oj 169 49 generation generation NN cord-104317-t30dg6oj 169 50 [ [ -LRB- cord-104317-t30dg6oj 169 51 89 89 CD cord-104317-t30dg6oj 169 52 ] ] -RRB- cord-104317-t30dg6oj 169 53 . . . cord-104317-t30dg6oj 170 1 However however RB cord-104317-t30dg6oj 170 2 , , , cord-104317-t30dg6oj 170 3 concern concern NN cord-104317-t30dg6oj 170 4 over over IN cord-104317-t30dg6oj 170 5 unknown unknown JJ cord-104317-t30dg6oj 170 6 health health NN cord-104317-t30dg6oj 170 7 implications implication NNS cord-104317-t30dg6oj 170 8 and and CC cord-104317-t30dg6oj 170 9 the the DT cord-104317-t30dg6oj 170 10 rise rise NN cord-104317-t30dg6oj 170 11 of of IN cord-104317-t30dg6oj 170 12 antibiotics antibiotic NNS cord-104317-t30dg6oj 170 13 stalled stall VBD cord-104317-t30dg6oj 170 14 the the DT cord-104317-t30dg6oj 170 15 field field NN cord-104317-t30dg6oj 170 16 , , , cord-104317-t30dg6oj 170 17 though though IN cord-104317-t30dg6oj 170 18 a a DT cord-104317-t30dg6oj 170 19 renaissance renaissance NN cord-104317-t30dg6oj 170 20 has have VBZ cord-104317-t30dg6oj 170 21 been be VBN cord-104317-t30dg6oj 170 22 building build VBG cord-104317-t30dg6oj 170 23 since since IN cord-104317-t30dg6oj 170 24 the the DT cord-104317-t30dg6oj 170 25 1990s 1990 NNS cord-104317-t30dg6oj 170 26 [ [ -LRB- cord-104317-t30dg6oj 170 27 90 90 CD cord-104317-t30dg6oj 170 28 ] ] -RRB- cord-104317-t30dg6oj 170 29 . . . cord-104317-t30dg6oj 171 1 Many many JJ cord-104317-t30dg6oj 171 2 different different JJ cord-104317-t30dg6oj 171 3 levels level NNS cord-104317-t30dg6oj 171 4 of of IN cord-104317-t30dg6oj 171 5 this this DT cord-104317-t30dg6oj 171 6 application application NN cord-104317-t30dg6oj 171 7 exist exist VBP cord-104317-t30dg6oj 171 8 , , , cord-104317-t30dg6oj 171 9 such such JJ cord-104317-t30dg6oj 171 10 as as IN cord-104317-t30dg6oj 171 11 treatment treatment NN cord-104317-t30dg6oj 171 12 of of IN cord-104317-t30dg6oj 171 13 animals animal NNS cord-104317-t30dg6oj 171 14 and and CC cord-104317-t30dg6oj 171 15 plants plant NNS cord-104317-t30dg6oj 171 16 with with IN cord-104317-t30dg6oj 171 17 phages phage NNS cord-104317-t30dg6oj 171 18 to to TO cord-104317-t30dg6oj 171 19 ensure ensure VB cord-104317-t30dg6oj 171 20 better well JJR cord-104317-t30dg6oj 171 21 yield yield NN cord-104317-t30dg6oj 171 22 as as RB cord-104317-t30dg6oj 171 23 well well RB cord-104317-t30dg6oj 171 24 as as IN cord-104317-t30dg6oj 171 25 to to TO cord-104317-t30dg6oj 171 26 kill kill VB cord-104317-t30dg6oj 171 27 human human JJ cord-104317-t30dg6oj 171 28 pathogens pathogen NNS cord-104317-t30dg6oj 171 29 that that WDT cord-104317-t30dg6oj 171 30 may may MD cord-104317-t30dg6oj 171 31 grow grow VB cord-104317-t30dg6oj 171 32 on on IN cord-104317-t30dg6oj 171 33 or or CC cord-104317-t30dg6oj 171 34 in in IN cord-104317-t30dg6oj 171 35 these these DT cord-104317-t30dg6oj 171 36 food food NN cord-104317-t30dg6oj 171 37 sources source NNS cord-104317-t30dg6oj 171 38 [ [ -LRB- cord-104317-t30dg6oj 171 39 91 91 CD cord-104317-t30dg6oj 171 40 ] ] -RRB- cord-104317-t30dg6oj 171 41 . . . cord-104317-t30dg6oj 172 1 Phages phage NNS cord-104317-t30dg6oj 172 2 are be VBP cord-104317-t30dg6oj 172 3 also also RB cord-104317-t30dg6oj 172 4 known know VBN cord-104317-t30dg6oj 172 5 to to TO cord-104317-t30dg6oj 172 6 be be VB cord-104317-t30dg6oj 172 7 able able JJ cord-104317-t30dg6oj 172 8 to to TO cord-104317-t30dg6oj 172 9 stimulate stimulate VB cord-104317-t30dg6oj 172 10 and/or and/or CC cord-104317-t30dg6oj 172 11 modulate modulate VB cord-104317-t30dg6oj 172 12 immune immune JJ cord-104317-t30dg6oj 172 13 action action NN cord-104317-t30dg6oj 172 14 in in IN cord-104317-t30dg6oj 172 15 humans human NNS cord-104317-t30dg6oj 172 16 at at IN cord-104317-t30dg6oj 172 17 multiple multiple JJ cord-104317-t30dg6oj 172 18 levels level NNS cord-104317-t30dg6oj 172 19 including include VBG cord-104317-t30dg6oj 172 20 antibody antibody NN cord-104317-t30dg6oj 172 21 generation generation NN cord-104317-t30dg6oj 172 22 , , , cord-104317-t30dg6oj 172 23 development development NN cord-104317-t30dg6oj 172 24 of of IN cord-104317-t30dg6oj 172 25 adaptive adaptive JJ cord-104317-t30dg6oj 172 26 immune immune JJ cord-104317-t30dg6oj 172 27 cells cell NNS cord-104317-t30dg6oj 172 28 , , , cord-104317-t30dg6oj 172 29 and and CC cord-104317-t30dg6oj 172 30 innate innate JJ cord-104317-t30dg6oj 172 31 pattern pattern NN cord-104317-t30dg6oj 172 32 recognition recognition NN cord-104317-t30dg6oj 172 33 ( ( -LRB- cord-104317-t30dg6oj 172 34 reviewed review VBN cord-104317-t30dg6oj 172 35 in in IN cord-104317-t30dg6oj 172 36 [ [ -LRB- cord-104317-t30dg6oj 172 37 88 88 CD cord-104317-t30dg6oj 172 38 ] ] -RRB- cord-104317-t30dg6oj 172 39 ) ) -RRB- cord-104317-t30dg6oj 172 40 , , , cord-104317-t30dg6oj 172 41 and and CC cord-104317-t30dg6oj 172 42 the the DT cord-104317-t30dg6oj 172 43 possible possible JJ cord-104317-t30dg6oj 172 44 applications application NNS cord-104317-t30dg6oj 172 45 of of IN cord-104317-t30dg6oj 172 46 phages phage NNS cord-104317-t30dg6oj 172 47 in in IN cord-104317-t30dg6oj 172 48 these these DT cord-104317-t30dg6oj 172 49 contexts context NNS cord-104317-t30dg6oj 172 50 are be VBP cord-104317-t30dg6oj 172 51 intriguing intriguing JJ cord-104317-t30dg6oj 172 52 . . . cord-104317-t30dg6oj 173 1 In in IN cord-104317-t30dg6oj 173 2 the the DT cord-104317-t30dg6oj 173 3 future future NN cord-104317-t30dg6oj 173 4 , , , cord-104317-t30dg6oj 173 5 sections section NNS cord-104317-t30dg6oj 173 6 of of IN cord-104317-t30dg6oj 173 7 this this DT cord-104317-t30dg6oj 173 8 group group NN cord-104317-t30dg6oj 173 9 may may MD cord-104317-t30dg6oj 173 10 be be VB cord-104317-t30dg6oj 173 11 able able JJ cord-104317-t30dg6oj 173 12 to to TO cord-104317-t30dg6oj 173 13 re re VB cord-104317-t30dg6oj 173 14 - - VBN cord-104317-t30dg6oj 173 15 classified classify VBN cord-104317-t30dg6oj 173 16 as as IN cord-104317-t30dg6oj 173 17 atypically atypically RB cord-104317-t30dg6oj 173 18 pathogenic pathogenic JJ cord-104317-t30dg6oj 173 19 or or CC cord-104317-t30dg6oj 173 20 mutualistic mutualistic JJ cord-104317-t30dg6oj 173 21 if if IN cord-104317-t30dg6oj 173 22 their -PRON- PRP$ cord-104317-t30dg6oj 173 23 presence presence NN cord-104317-t30dg6oj 173 24 can can MD cord-104317-t30dg6oj 173 25 be be VB cord-104317-t30dg6oj 173 26 linked link VBN cord-104317-t30dg6oj 173 27 to to IN cord-104317-t30dg6oj 173 28 roles role NNS cord-104317-t30dg6oj 173 29 in in IN cord-104317-t30dg6oj 173 30 specific specific JJ cord-104317-t30dg6oj 173 31 disease disease NN cord-104317-t30dg6oj 173 32 phenotypes phenotype NNS cord-104317-t30dg6oj 173 33 , , , cord-104317-t30dg6oj 173 34 but but CC cord-104317-t30dg6oj 173 35 for for IN cord-104317-t30dg6oj 173 36 now now RB cord-104317-t30dg6oj 173 37 they -PRON- PRP cord-104317-t30dg6oj 173 38 are be VBP cord-104317-t30dg6oj 173 39 most most RBS cord-104317-t30dg6oj 173 40 appropriately appropriately RB cord-104317-t30dg6oj 173 41 classified classify VBN cord-104317-t30dg6oj 173 42 as as IN cord-104317-t30dg6oj 173 43 commensal commensal JJ cord-104317-t30dg6oj 173 44 . . . cord-104317-t30dg6oj 174 1 Viruses virus NNS cord-104317-t30dg6oj 174 2 can can MD cord-104317-t30dg6oj 174 3 also also RB cord-104317-t30dg6oj 174 4 infect infect VB cord-104317-t30dg6oj 174 5 fungal fungal JJ cord-104317-t30dg6oj 174 6 members member NNS cord-104317-t30dg6oj 174 7 of of IN cord-104317-t30dg6oj 174 8 the the DT cord-104317-t30dg6oj 174 9 human human JJ cord-104317-t30dg6oj 174 10 microbiome microbiome NN cord-104317-t30dg6oj 174 11 ( ( -LRB- cord-104317-t30dg6oj 174 12 mycoviruses mycoviruses NNP cord-104317-t30dg6oj 174 13 ) ) -RRB- cord-104317-t30dg6oj 174 14 and and CC cord-104317-t30dg6oj 174 15 protozoa protozoan NNS cord-104317-t30dg6oj 174 16 of of IN cord-104317-t30dg6oj 174 17 the the DT cord-104317-t30dg6oj 174 18 human human JJ cord-104317-t30dg6oj 174 19 macrobiome macrobiome NNP cord-104317-t30dg6oj 174 20 [ [ -LRB- cord-104317-t30dg6oj 174 21 77 77 CD cord-104317-t30dg6oj 174 22 , , , cord-104317-t30dg6oj 174 23 [ [ -LRB- cord-104317-t30dg6oj 174 24 92 92 CD cord-104317-t30dg6oj 174 25 ] ] -RRB- cord-104317-t30dg6oj 174 26 [ [ -LRB- cord-104317-t30dg6oj 174 27 93 93 CD cord-104317-t30dg6oj 174 28 ] ] -RRB- cord-104317-t30dg6oj 174 29 [ [ -LRB- cord-104317-t30dg6oj 174 30 94 94 CD cord-104317-t30dg6oj 174 31 ] ] -RRB- cord-104317-t30dg6oj 174 32 [ [ -LRB- cord-104317-t30dg6oj 174 33 95 95 CD cord-104317-t30dg6oj 174 34 ] ] -RRB- cord-104317-t30dg6oj 174 35 [ [ -LRB- cord-104317-t30dg6oj 174 36 96 96 CD cord-104317-t30dg6oj 174 37 ] ] -RRB- cord-104317-t30dg6oj 174 38 [ [ -LRB- cord-104317-t30dg6oj 174 39 97 97 CD cord-104317-t30dg6oj 174 40 ] ] -RRB- cord-104317-t30dg6oj 174 41 [ [ -LRB- cord-104317-t30dg6oj 174 42 98 98 CD cord-104317-t30dg6oj 174 43 ] ] -RRB- cord-104317-t30dg6oj 174 44 . . . cord-104317-t30dg6oj 175 1 While while IN cord-104317-t30dg6oj 175 2 much much RB cord-104317-t30dg6oj 175 3 less less JJR cord-104317-t30dg6oj 175 4 is be VBZ cord-104317-t30dg6oj 175 5 known know VBN cord-104317-t30dg6oj 175 6 about about IN cord-104317-t30dg6oj 175 7 these these DT cord-104317-t30dg6oj 175 8 particular particular JJ cord-104317-t30dg6oj 175 9 types type NNS cord-104317-t30dg6oj 175 10 of of IN cord-104317-t30dg6oj 175 11 viruses virus NNS cord-104317-t30dg6oj 175 12 , , , cord-104317-t30dg6oj 175 13 similar similar JJ cord-104317-t30dg6oj 175 14 conjectures conjecture NNS cord-104317-t30dg6oj 175 15 have have VBP cord-104317-t30dg6oj 175 16 been be VBN cord-104317-t30dg6oj 175 17 made make VBN cord-104317-t30dg6oj 175 18 as as IN cord-104317-t30dg6oj 175 19 for for IN cord-104317-t30dg6oj 175 20 phages phage NNS cord-104317-t30dg6oj 175 21 in in IN cord-104317-t30dg6oj 175 22 regard regard NN cord-104317-t30dg6oj 175 23 to to IN cord-104317-t30dg6oj 175 24 their -PRON- PRP$ cord-104317-t30dg6oj 175 25 potential potential NN cord-104317-t30dg6oj 175 26 as as IN cord-104317-t30dg6oj 175 27 both both DT cord-104317-t30dg6oj 175 28 atypical atypical JJ cord-104317-t30dg6oj 175 29 pathogens pathogen NNS cord-104317-t30dg6oj 175 30 and and CC cord-104317-t30dg6oj 175 31 mutualists mutualist NNS cord-104317-t30dg6oj 175 32 . . . cord-104317-t30dg6oj 176 1 Direct direct JJ cord-104317-t30dg6oj 176 2 effects effect NNS cord-104317-t30dg6oj 176 3 on on IN cord-104317-t30dg6oj 176 4 human human JJ cord-104317-t30dg6oj 176 5 health health NN cord-104317-t30dg6oj 176 6 are be VBP cord-104317-t30dg6oj 176 7 likely likely RB cord-104317-t30dg6oj 176 8 rare rare JJ cord-104317-t30dg6oj 176 9 , , , cord-104317-t30dg6oj 176 10 though though IN cord-104317-t30dg6oj 176 11 they -PRON- PRP cord-104317-t30dg6oj 176 12 have have VBP cord-104317-t30dg6oj 176 13 been be VBN cord-104317-t30dg6oj 176 14 observed observe VBN cord-104317-t30dg6oj 176 15 for for IN cord-104317-t30dg6oj 176 16 protozoan protozoan NN cord-104317-t30dg6oj 176 17 parasite parasite NN cord-104317-t30dg6oj 176 18 viruses virus NNS cord-104317-t30dg6oj 176 19 ( ( -LRB- cord-104317-t30dg6oj 176 20 see see VB cord-104317-t30dg6oj 176 21 Atypically atypically RB cord-104317-t30dg6oj 176 22 Pathogenic pathogenic JJ cord-104317-t30dg6oj 176 23 Viruses Viruses NNPS cord-104317-t30dg6oj 176 24 , , , cord-104317-t30dg6oj 176 25 above above RB cord-104317-t30dg6oj 176 26 ) ) -RRB- cord-104317-t30dg6oj 176 27 . . . cord-104317-t30dg6oj 177 1 The the DT cord-104317-t30dg6oj 177 2 presence presence NN cord-104317-t30dg6oj 177 3 of of IN cord-104317-t30dg6oj 177 4 these these DT cord-104317-t30dg6oj 177 5 viruses virus NNS cord-104317-t30dg6oj 177 6 may may MD cord-104317-t30dg6oj 177 7 ultimately ultimately RB cord-104317-t30dg6oj 177 8 have have VB cord-104317-t30dg6oj 177 9 an an DT cord-104317-t30dg6oj 177 10 indirect indirect JJ cord-104317-t30dg6oj 177 11 effect effect NN cord-104317-t30dg6oj 177 12 on on IN cord-104317-t30dg6oj 177 13 human human JJ cord-104317-t30dg6oj 177 14 health health NN cord-104317-t30dg6oj 177 15 of of IN cord-104317-t30dg6oj 177 16 unknown unknown JJ cord-104317-t30dg6oj 177 17 consequence consequence NN cord-104317-t30dg6oj 177 18 . . . cord-104317-t30dg6oj 178 1 Investigation investigation NN cord-104317-t30dg6oj 178 2 of of IN cord-104317-t30dg6oj 178 3 the the DT cord-104317-t30dg6oj 178 4 breadth breadth NN cord-104317-t30dg6oj 178 5 and and CC cord-104317-t30dg6oj 178 6 impact impact NN cord-104317-t30dg6oj 178 7 of of IN cord-104317-t30dg6oj 178 8 such such JJ cord-104317-t30dg6oj 178 9 viruses virus NNS cord-104317-t30dg6oj 178 10 is be VBZ cord-104317-t30dg6oj 178 11 an an DT cord-104317-t30dg6oj 178 12 interesting interesting JJ cord-104317-t30dg6oj 178 13 and and CC cord-104317-t30dg6oj 178 14 important important JJ cord-104317-t30dg6oj 178 15 area area NN cord-104317-t30dg6oj 178 16 of of IN cord-104317-t30dg6oj 178 17 future future JJ cord-104317-t30dg6oj 178 18 research research NN cord-104317-t30dg6oj 178 19 , , , cord-104317-t30dg6oj 178 20 particularly particularly RB cord-104317-t30dg6oj 178 21 for for IN cord-104317-t30dg6oj 178 22 the the DT cord-104317-t30dg6oj 178 23 benefit benefit NN cord-104317-t30dg6oj 178 24 of of IN cord-104317-t30dg6oj 178 25 the the DT cord-104317-t30dg6oj 178 26 immunocompromised immunocompromised JJ cord-104317-t30dg6oj 178 27 and and CC cord-104317-t30dg6oj 178 28 those those DT cord-104317-t30dg6oj 178 29 in in IN cord-104317-t30dg6oj 178 30 developing develop VBG cord-104317-t30dg6oj 178 31 countries country NNS cord-104317-t30dg6oj 178 32 who who WP cord-104317-t30dg6oj 178 33 are be VBP cord-104317-t30dg6oj 178 34 most most RBS cord-104317-t30dg6oj 178 35 affected affect VBN cord-104317-t30dg6oj 178 36 by by IN cord-104317-t30dg6oj 178 37 diseases disease NNS cord-104317-t30dg6oj 178 38 caused cause VBN cord-104317-t30dg6oj 178 39 by by IN cord-104317-t30dg6oj 178 40 fungi fungus NNS cord-104317-t30dg6oj 178 41 and and CC cord-104317-t30dg6oj 178 42 protozoa protozoan NNS cord-104317-t30dg6oj 178 43 . . . cord-104317-t30dg6oj 179 1 There there EX cord-104317-t30dg6oj 179 2 is be VBZ cord-104317-t30dg6oj 179 3 also also RB cord-104317-t30dg6oj 179 4 an an DT cord-104317-t30dg6oj 179 5 abundance abundance NN cord-104317-t30dg6oj 179 6 of of IN cord-104317-t30dg6oj 179 7 prototypically prototypically RB cord-104317-t30dg6oj 179 8 planttropic planttropic JJ cord-104317-t30dg6oj 179 9 viruses virus NNS cord-104317-t30dg6oj 179 10 found find VBN cord-104317-t30dg6oj 179 11 in in IN cord-104317-t30dg6oj 179 12 the the DT cord-104317-t30dg6oj 179 13 human human JJ cord-104317-t30dg6oj 179 14 gut gut NN cord-104317-t30dg6oj 179 15 [ [ -LRB- cord-104317-t30dg6oj 179 16 99 99 CD cord-104317-t30dg6oj 179 17 ] ] -RRB- cord-104317-t30dg6oj 179 18 . . . cord-104317-t30dg6oj 180 1 It -PRON- PRP cord-104317-t30dg6oj 180 2 is be VBZ cord-104317-t30dg6oj 180 3 likely likely RB cord-104317-t30dg6oj 180 4 these these DT cord-104317-t30dg6oj 180 5 viruses virus NNS cord-104317-t30dg6oj 180 6 have have VBP cord-104317-t30dg6oj 180 7 been be VBN cord-104317-t30dg6oj 180 8 acquired acquire VBN cord-104317-t30dg6oj 180 9 via via IN cord-104317-t30dg6oj 180 10 agricultural agricultural JJ cord-104317-t30dg6oj 180 11 crops crop NNS cord-104317-t30dg6oj 180 12 in in IN cord-104317-t30dg6oj 180 13 the the DT cord-104317-t30dg6oj 180 14 diet diet NN cord-104317-t30dg6oj 180 15 and and CC cord-104317-t30dg6oj 180 16 the the DT cord-104317-t30dg6oj 180 17 effect effect NN cord-104317-t30dg6oj 180 18 of of IN cord-104317-t30dg6oj 180 19 their -PRON- PRP$ cord-104317-t30dg6oj 180 20 presence presence NN cord-104317-t30dg6oj 180 21 is be VBZ cord-104317-t30dg6oj 180 22 unknown unknown JJ cord-104317-t30dg6oj 180 23 , , , cord-104317-t30dg6oj 180 24 but but CC cord-104317-t30dg6oj 180 25 assembly assembly NN cord-104317-t30dg6oj 180 26 of of IN cord-104317-t30dg6oj 180 27 plant plant NN cord-104317-t30dg6oj 180 28 viral viral JJ cord-104317-t30dg6oj 180 29 particles particle NNS cord-104317-t30dg6oj 180 30 in in IN cord-104317-t30dg6oj 180 31 Escherichia Escherichia NNP cord-104317-t30dg6oj 180 32 coli coli NNS cord-104317-t30dg6oj 180 33 has have VBZ cord-104317-t30dg6oj 180 34 been be VBN cord-104317-t30dg6oj 180 35 exhibited exhibit VBN cord-104317-t30dg6oj 180 36 , , , cord-104317-t30dg6oj 180 37 so so CC cord-104317-t30dg6oj 180 38 it -PRON- PRP cord-104317-t30dg6oj 180 39 is be VBZ cord-104317-t30dg6oj 180 40 possible possible JJ cord-104317-t30dg6oj 180 41 that that IN cord-104317-t30dg6oj 180 42 these these DT cord-104317-t30dg6oj 180 43 viruses virus NNS cord-104317-t30dg6oj 180 44 may may MD cord-104317-t30dg6oj 180 45 interact interact VB cord-104317-t30dg6oj 180 46 with with IN cord-104317-t30dg6oj 180 47 gut gut NN cord-104317-t30dg6oj 180 48 bacteria bacteria NNS cord-104317-t30dg6oj 180 49 [ [ -LRB- cord-104317-t30dg6oj 180 50 100 100 CD cord-104317-t30dg6oj 180 51 ] ] -RRB- cord-104317-t30dg6oj 180 52 . . . cord-104317-t30dg6oj 181 1 Some some DT cord-104317-t30dg6oj 181 2 commensal commensal JJ cord-104317-t30dg6oj 181 3 viruses virus NNS cord-104317-t30dg6oj 181 4 can can MD cord-104317-t30dg6oj 181 5 infect infect VB cord-104317-t30dg6oj 181 6 human human JJ cord-104317-t30dg6oj 181 7 cells cell NNS cord-104317-t30dg6oj 181 8 and and CC cord-104317-t30dg6oj 181 9 use use VB cord-104317-t30dg6oj 181 10 the the DT cord-104317-t30dg6oj 181 11 human human NN cord-104317-t30dg6oj 181 12 as as IN cord-104317-t30dg6oj 181 13 a a DT cord-104317-t30dg6oj 181 14 vessel vessel NN cord-104317-t30dg6oj 181 15 for for IN cord-104317-t30dg6oj 181 16 transmission transmission NN cord-104317-t30dg6oj 181 17 . . . cord-104317-t30dg6oj 182 1 These these DT cord-104317-t30dg6oj 182 2 viruses virus NNS cord-104317-t30dg6oj 182 3 establish establish VBP cord-104317-t30dg6oj 182 4 asymptomatic asymptomatic JJ cord-104317-t30dg6oj 182 5 infections infection NNS cord-104317-t30dg6oj 182 6 that that WDT cord-104317-t30dg6oj 182 7 do do VBP cord-104317-t30dg6oj 182 8 not not RB cord-104317-t30dg6oj 182 9 result result VB cord-104317-t30dg6oj 182 10 in in IN cord-104317-t30dg6oj 182 11 a a DT cord-104317-t30dg6oj 182 12 change change NN cord-104317-t30dg6oj 182 13 in in IN cord-104317-t30dg6oj 182 14 host host NN cord-104317-t30dg6oj 182 15 health health NN cord-104317-t30dg6oj 182 16 or or CC cord-104317-t30dg6oj 182 17 behavior behavior NN cord-104317-t30dg6oj 182 18 . . . cord-104317-t30dg6oj 183 1 This this DT cord-104317-t30dg6oj 183 2 represents represent VBZ cord-104317-t30dg6oj 183 3 a a DT cord-104317-t30dg6oj 183 4 veritable veritable JJ cord-104317-t30dg6oj 183 5 antithesis antithesis NN cord-104317-t30dg6oj 183 6 to to IN cord-104317-t30dg6oj 183 7 the the DT cord-104317-t30dg6oj 183 8 strategy strategy NN cord-104317-t30dg6oj 183 9 of of IN cord-104317-t30dg6oj 183 10 parasitic parasitic JJ cord-104317-t30dg6oj 183 11 human human JJ cord-104317-t30dg6oj 183 12 viruses virus NNS cord-104317-t30dg6oj 183 13 ( ( -LRB- cord-104317-t30dg6oj 183 14 see see VB cord-104317-t30dg6oj 183 15 The the DT cord-104317-t30dg6oj 183 16 Parasitic Parasitic NNP cord-104317-t30dg6oj 183 17 Virome Virome NNP cord-104317-t30dg6oj 183 18 , , , cord-104317-t30dg6oj 183 19 above above RB cord-104317-t30dg6oj 183 20 ) ) -RRB- cord-104317-t30dg6oj 183 21 , , , cord-104317-t30dg6oj 183 22 wherein wherein WRB cord-104317-t30dg6oj 183 23 viruses virus NNS cord-104317-t30dg6oj 183 24 have have VBP cord-104317-t30dg6oj 183 25 prioritized prioritize VBN cord-104317-t30dg6oj 183 26 trade trade NN cord-104317-t30dg6oj 183 27 - - HYPH cord-104317-t30dg6oj 183 28 offs off NNS cord-104317-t30dg6oj 183 29 other other JJ cord-104317-t30dg6oj 183 30 than than IN cord-104317-t30dg6oj 183 31 pathogenicity pathogenicity NN cord-104317-t30dg6oj 183 32 to to TO cord-104317-t30dg6oj 183 33 ensure ensure VB cord-104317-t30dg6oj 183 34 their -PRON- PRP$ cord-104317-t30dg6oj 183 35 transmission transmission NN cord-104317-t30dg6oj 183 36 to to IN cord-104317-t30dg6oj 183 37 a a DT cord-104317-t30dg6oj 183 38 new new JJ cord-104317-t30dg6oj 183 39 host host NN cord-104317-t30dg6oj 183 40 . . . cord-104317-t30dg6oj 184 1 The the DT cord-104317-t30dg6oj 184 2 most most RBS cord-104317-t30dg6oj 184 3 well well RB cord-104317-t30dg6oj 184 4 documented document VBN cord-104317-t30dg6oj 184 5 examples example NNS cord-104317-t30dg6oj 184 6 of of IN cord-104317-t30dg6oj 184 7 asymptomatic asymptomatic JJ cord-104317-t30dg6oj 184 8 infection infection NN cord-104317-t30dg6oj 184 9 of of IN cord-104317-t30dg6oj 184 10 humans human NNS cord-104317-t30dg6oj 184 11 by by IN cord-104317-t30dg6oj 184 12 commensal commensal JJ cord-104317-t30dg6oj 184 13 viruses virus NNS cord-104317-t30dg6oj 184 14 are be VBP cord-104317-t30dg6oj 184 15 the the DT cord-104317-t30dg6oj 184 16 rhinoviruses rhinovirus NNS cord-104317-t30dg6oj 184 17 and and CC cord-104317-t30dg6oj 184 18 other other JJ cord-104317-t30dg6oj 184 19 infections infection NNS cord-104317-t30dg6oj 184 20 of of IN cord-104317-t30dg6oj 184 21 the the DT cord-104317-t30dg6oj 184 22 nasopharynx nasopharynx NN cord-104317-t30dg6oj 184 23 and and CC cord-104317-t30dg6oj 184 24 upper upper JJ cord-104317-t30dg6oj 184 25 respiratory respiratory JJ cord-104317-t30dg6oj 184 26 tract tract NN cord-104317-t30dg6oj 184 27 [ [ -LRB- cord-104317-t30dg6oj 184 28 80 80 CD cord-104317-t30dg6oj 184 29 , , , cord-104317-t30dg6oj 184 30 [ [ -LRB- cord-104317-t30dg6oj 184 31 101 101 CD cord-104317-t30dg6oj 184 32 ] ] -RRB- cord-104317-t30dg6oj 184 33 [ [ -LRB- cord-104317-t30dg6oj 184 34 102 102 CD cord-104317-t30dg6oj 184 35 ] ] -RRB- cord-104317-t30dg6oj 184 36 [ [ -LRB- cord-104317-t30dg6oj 184 37 103 103 CD cord-104317-t30dg6oj 184 38 ] ] -RRB- cord-104317-t30dg6oj 184 39 [ [ -LRB- cord-104317-t30dg6oj 184 40 104 104 CD cord-104317-t30dg6oj 184 41 ] ] -RRB- cord-104317-t30dg6oj 184 42 . . . cord-104317-t30dg6oj 185 1 Many many JJ cord-104317-t30dg6oj 185 2 of of IN cord-104317-t30dg6oj 185 3 the the DT cord-104317-t30dg6oj 185 4 Human Human NNP cord-104317-t30dg6oj 185 5 Papilloma papilloma NN cord-104317-t30dg6oj 185 6 Viruses virus NNS cord-104317-t30dg6oj 185 7 ( ( -LRB- cord-104317-t30dg6oj 185 8 HPVs hpvs XX cord-104317-t30dg6oj 185 9 ) ) -RRB- cord-104317-t30dg6oj 185 10 interact interact VB cord-104317-t30dg6oj 185 11 with with IN cord-104317-t30dg6oj 185 12 human human JJ cord-104317-t30dg6oj 185 13 cells cell NNS cord-104317-t30dg6oj 185 14 as as IN cord-104317-t30dg6oj 185 15 an an DT cord-104317-t30dg6oj 185 16 asymptomatic asymptomatic JJ cord-104317-t30dg6oj 185 17 infection infection NN cord-104317-t30dg6oj 185 18 of of IN cord-104317-t30dg6oj 185 19 mucous mucous JJ cord-104317-t30dg6oj 185 20 membranes membrane NNS cord-104317-t30dg6oj 185 21 or or CC cord-104317-t30dg6oj 185 22 skin skin NN cord-104317-t30dg6oj 185 23 [ [ -LRB- cord-104317-t30dg6oj 185 24 105 105 CD cord-104317-t30dg6oj 185 25 ] ] -RRB- cord-104317-t30dg6oj 185 26 . . . cord-104317-t30dg6oj 186 1 Anelloviruses anelloviruse NNS cord-104317-t30dg6oj 186 2 are be VBP cord-104317-t30dg6oj 186 3 also also RB cord-104317-t30dg6oj 186 4 well well RB cord-104317-t30dg6oj 186 5 described describe VBN cord-104317-t30dg6oj 186 6 human human JJ cord-104317-t30dg6oj 186 7 commensals commensal NNS cord-104317-t30dg6oj 186 8 [ [ -LRB- cord-104317-t30dg6oj 186 9 106 106 CD cord-104317-t30dg6oj 186 10 ] ] -RRB- cord-104317-t30dg6oj 186 11 [ [ -LRB- cord-104317-t30dg6oj 186 12 107 107 CD cord-104317-t30dg6oj 186 13 ] ] -RRB- cord-104317-t30dg6oj 186 14 [ [ -LRB- cord-104317-t30dg6oj 186 15 108 108 CD cord-104317-t30dg6oj 186 16 ] ] -RRB- cord-104317-t30dg6oj 186 17 [ [ -LRB- cord-104317-t30dg6oj 186 18 109 109 CD cord-104317-t30dg6oj 186 19 ] ] -RRB- cord-104317-t30dg6oj 186 20 [ [ -LRB- cord-104317-t30dg6oj 186 21 110 110 CD cord-104317-t30dg6oj 186 22 ] ] -RRB- cord-104317-t30dg6oj 186 23 . . . cord-104317-t30dg6oj 187 1 While while IN cord-104317-t30dg6oj 187 2 immune immune JJ cord-104317-t30dg6oj 187 3 detection detection NN cord-104317-t30dg6oj 187 4 of of IN cord-104317-t30dg6oj 187 5 non non JJ cord-104317-t30dg6oj 187 6 - - JJ cord-104317-t30dg6oj 187 7 human human JJ cord-104317-t30dg6oj 187 8 tropic tropic NN cord-104317-t30dg6oj 187 9 commensal commensal NN cord-104317-t30dg6oj 187 10 viruses virus NNS cord-104317-t30dg6oj 187 11 is be VBZ cord-104317-t30dg6oj 187 12 avoided avoid VBN cord-104317-t30dg6oj 187 13 by by IN cord-104317-t30dg6oj 187 14 physical physical JJ cord-104317-t30dg6oj 187 15 separation separation NN cord-104317-t30dg6oj 187 16 , , , cord-104317-t30dg6oj 187 17 the the DT cord-104317-t30dg6oj 187 18 human human JJ cord-104317-t30dg6oj 187 19 - - HYPH cord-104317-t30dg6oj 187 20 tropic tropic NN cord-104317-t30dg6oj 187 21 commensal commensal NN cord-104317-t30dg6oj 187 22 viruses virus NNS cord-104317-t30dg6oj 187 23 assuredly assuredly RB cord-104317-t30dg6oj 187 24 engage engage VBP cord-104317-t30dg6oj 187 25 with with IN cord-104317-t30dg6oj 187 26 host host NN cord-104317-t30dg6oj 187 27 innate innate JJ cord-104317-t30dg6oj 187 28 and and CC cord-104317-t30dg6oj 187 29 adaptive adaptive JJ cord-104317-t30dg6oj 187 30 immune immune JJ cord-104317-t30dg6oj 187 31 responses response NNS cord-104317-t30dg6oj 187 32 , , , cord-104317-t30dg6oj 187 33 and and CC cord-104317-t30dg6oj 187 34 so so RB cord-104317-t30dg6oj 187 35 must must MD cord-104317-t30dg6oj 187 36 avoid avoid VB cord-104317-t30dg6oj 187 37 or or CC cord-104317-t30dg6oj 187 38 subvert subvert VB cord-104317-t30dg6oj 187 39 these these DT cord-104317-t30dg6oj 187 40 mechanisms mechanism NNS cord-104317-t30dg6oj 187 41 to to TO cord-104317-t30dg6oj 187 42 maintain maintain VB cord-104317-t30dg6oj 187 43 their -PRON- PRP$ cord-104317-t30dg6oj 187 44 immunological immunological JJ cord-104317-t30dg6oj 187 45 silence silence NN cord-104317-t30dg6oj 187 46 . . . cord-104317-t30dg6oj 188 1 Description description NN cord-104317-t30dg6oj 188 2 of of IN cord-104317-t30dg6oj 188 3 the the DT cord-104317-t30dg6oj 188 4 viral viral JJ cord-104317-t30dg6oj 188 5 techniques technique NNS cord-104317-t30dg6oj 188 6 enabling enable VBG cord-104317-t30dg6oj 188 7 this this DT cord-104317-t30dg6oj 188 8 evasion evasion NN cord-104317-t30dg6oj 188 9 is be VBZ cord-104317-t30dg6oj 188 10 an an DT cord-104317-t30dg6oj 188 11 important important JJ cord-104317-t30dg6oj 188 12 direction direction NN cord-104317-t30dg6oj 188 13 for for IN cord-104317-t30dg6oj 188 14 future future JJ cord-104317-t30dg6oj 188 15 research research NN cord-104317-t30dg6oj 188 16 on on IN cord-104317-t30dg6oj 188 17 these these DT cord-104317-t30dg6oj 188 18 viruses virus NNS cord-104317-t30dg6oj 188 19 , , , cord-104317-t30dg6oj 188 20 as as IN cord-104317-t30dg6oj 188 21 this this DT cord-104317-t30dg6oj 188 22 may may MD cord-104317-t30dg6oj 188 23 point point VB cord-104317-t30dg6oj 188 24 to to IN cord-104317-t30dg6oj 188 25 novel novel JJ cord-104317-t30dg6oj 188 26 avenues avenue NNS cord-104317-t30dg6oj 188 27 of of IN cord-104317-t30dg6oj 188 28 therapeutic therapeutic JJ cord-104317-t30dg6oj 188 29 intervention intervention NN cord-104317-t30dg6oj 188 30 for for IN cord-104317-t30dg6oj 188 31 suppression suppression NN cord-104317-t30dg6oj 188 32 or or CC cord-104317-t30dg6oj 188 33 activation activation NN cord-104317-t30dg6oj 188 34 of of IN cord-104317-t30dg6oj 188 35 immune immune JJ cord-104317-t30dg6oj 188 36 responses response NNS cord-104317-t30dg6oj 188 37 . . . cord-104317-t30dg6oj 189 1 While while IN cord-104317-t30dg6oj 189 2 commensal commensal JJ cord-104317-t30dg6oj 189 3 viruses virus NNS cord-104317-t30dg6oj 189 4 do do VBP cord-104317-t30dg6oj 189 5 not not RB cord-104317-t30dg6oj 189 6 have have VB cord-104317-t30dg6oj 189 7 any any DT cord-104317-t30dg6oj 189 8 direct direct JJ cord-104317-t30dg6oj 189 9 effect effect NN cord-104317-t30dg6oj 189 10 on on IN cord-104317-t30dg6oj 189 11 human human JJ cord-104317-t30dg6oj 189 12 health health NN cord-104317-t30dg6oj 189 13 during during IN cord-104317-t30dg6oj 189 14 homeostatic homeostatic JJ cord-104317-t30dg6oj 189 15 equilibrium equilibrium NN cord-104317-t30dg6oj 189 16 , , , cord-104317-t30dg6oj 189 17 perturbation perturbation NN cord-104317-t30dg6oj 189 18 of of IN cord-104317-t30dg6oj 189 19 homeostasis homeostasis NN cord-104317-t30dg6oj 189 20 may may MD cord-104317-t30dg6oj 189 21 cause cause VB cord-104317-t30dg6oj 189 22 them -PRON- PRP cord-104317-t30dg6oj 189 23 to to TO cord-104317-t30dg6oj 189 24 contribute contribute VB cord-104317-t30dg6oj 189 25 to to IN cord-104317-t30dg6oj 189 26 pathogenesis pathogenesis NN cord-104317-t30dg6oj 189 27 ( ( -LRB- cord-104317-t30dg6oj 189 28 see see VB cord-104317-t30dg6oj 189 29 Atypically atypically RB cord-104317-t30dg6oj 189 30 Pathogenic pathogenic JJ cord-104317-t30dg6oj 189 31 Viruses Viruses NNPS cord-104317-t30dg6oj 189 32 , , , cord-104317-t30dg6oj 189 33 above above RB cord-104317-t30dg6oj 189 34 ) ) -RRB- cord-104317-t30dg6oj 189 35 . . . cord-104317-t30dg6oj 190 1 Contrarily contrarily RB cord-104317-t30dg6oj 190 2 , , , cord-104317-t30dg6oj 190 3 the the DT cord-104317-t30dg6oj 190 4 presence presence NN cord-104317-t30dg6oj 190 5 of of IN cord-104317-t30dg6oj 190 6 viruses virus NNS cord-104317-t30dg6oj 190 7 from from IN cord-104317-t30dg6oj 190 8 the the DT cord-104317-t30dg6oj 190 9 final final JJ cord-104317-t30dg6oj 190 10 major major JJ cord-104317-t30dg6oj 190 11 group group NN cord-104317-t30dg6oj 190 12 of of IN cord-104317-t30dg6oj 190 13 the the DT cord-104317-t30dg6oj 190 14 human human JJ cord-104317-t30dg6oj 190 15 virome virome NN cord-104317-t30dg6oj 190 16 , , , cord-104317-t30dg6oj 190 17 mutualistic mutualistic JJ cord-104317-t30dg6oj 190 18 viruses virus NNS cord-104317-t30dg6oj 190 19 , , , cord-104317-t30dg6oj 190 20 exhibit exhibit VB cord-104317-t30dg6oj 190 21 positive positive JJ cord-104317-t30dg6oj 190 22 effects effect NNS cord-104317-t30dg6oj 190 23 on on IN cord-104317-t30dg6oj 190 24 host host NN cord-104317-t30dg6oj 190 25 health health NN cord-104317-t30dg6oj 190 26 via via IN cord-104317-t30dg6oj 190 27 an an DT cord-104317-t30dg6oj 190 28 assortment assortment NN cord-104317-t30dg6oj 190 29 of of IN cord-104317-t30dg6oj 190 30 mechanisms mechanism NNS cord-104317-t30dg6oj 190 31 . . . cord-104317-t30dg6oj 191 1 Perhaps perhaps RB cord-104317-t30dg6oj 191 2 the the DT cord-104317-t30dg6oj 191 3 most most RBS cord-104317-t30dg6oj 191 4 underappreciated underappreciated JJ cord-104317-t30dg6oj 191 5 portion portion NN cord-104317-t30dg6oj 191 6 of of IN cord-104317-t30dg6oj 191 7 the the DT cord-104317-t30dg6oj 191 8 virome virome NN cord-104317-t30dg6oj 191 9 are be VBP cord-104317-t30dg6oj 191 10 those those DT cord-104317-t30dg6oj 191 11 viruses virus NNS cord-104317-t30dg6oj 191 12 that that WDT cord-104317-t30dg6oj 191 13 have have VBP cord-104317-t30dg6oj 191 14 a a DT cord-104317-t30dg6oj 191 15 positive positive JJ cord-104317-t30dg6oj 191 16 health health NN cord-104317-t30dg6oj 191 17 benefit benefit NN cord-104317-t30dg6oj 191 18 for for IN cord-104317-t30dg6oj 191 19 humans human NNS cord-104317-t30dg6oj 191 20 . . . cord-104317-t30dg6oj 192 1 A a DT cord-104317-t30dg6oj 192 2 mutualistic mutualistic JJ cord-104317-t30dg6oj 192 3 interaction interaction NN cord-104317-t30dg6oj 192 4 is be VBZ cord-104317-t30dg6oj 192 5 one one NN cord-104317-t30dg6oj 192 6 that that WDT cord-104317-t30dg6oj 192 7 benefits benefit VBZ cord-104317-t30dg6oj 192 8 both both DT cord-104317-t30dg6oj 192 9 organisms organism NNS cord-104317-t30dg6oj 192 10 involved involve VBD cord-104317-t30dg6oj 192 11 [ [ -LRB- cord-104317-t30dg6oj 192 12 111 111 CD cord-104317-t30dg6oj 192 13 ] ] -RRB- cord-104317-t30dg6oj 192 14 . . . cord-104317-t30dg6oj 193 1 It -PRON- PRP cord-104317-t30dg6oj 193 2 is be VBZ cord-104317-t30dg6oj 193 3 reasonable reasonable JJ cord-104317-t30dg6oj 193 4 to to TO cord-104317-t30dg6oj 193 5 assume assume VB cord-104317-t30dg6oj 193 6 that that IN cord-104317-t30dg6oj 193 7 it -PRON- PRP cord-104317-t30dg6oj 193 8 may may MD cord-104317-t30dg6oj 193 9 be be VB cord-104317-t30dg6oj 193 10 beneficial beneficial JJ cord-104317-t30dg6oj 193 11 for for IN cord-104317-t30dg6oj 193 12 a a DT cord-104317-t30dg6oj 193 13 virus virus NN cord-104317-t30dg6oj 193 14 to to TO cord-104317-t30dg6oj 193 15 encourage encourage VB cord-104317-t30dg6oj 193 16 and and CC cord-104317-t30dg6oj 193 17 aid aid VB cord-104317-t30dg6oj 193 18 in in IN cord-104317-t30dg6oj 193 19 its -PRON- PRP$ cord-104317-t30dg6oj 193 20 host host NN cord-104317-t30dg6oj 193 21 's 's POS cord-104317-t30dg6oj 193 22 health health NN cord-104317-t30dg6oj 193 23 to to TO cord-104317-t30dg6oj 193 24 facilitate facilitate VB cord-104317-t30dg6oj 193 25 a a DT cord-104317-t30dg6oj 193 26 longer long RBR cord-104317-t30dg6oj 193 27 lasting lasting JJ cord-104317-t30dg6oj 193 28 and and CC cord-104317-t30dg6oj 193 29 amenable amenable JJ cord-104317-t30dg6oj 193 30 environment environment NN cord-104317-t30dg6oj 193 31 for for IN cord-104317-t30dg6oj 193 32 survival survival NN cord-104317-t30dg6oj 193 33 . . . cord-104317-t30dg6oj 194 1 But but CC cord-104317-t30dg6oj 194 2 this this DT cord-104317-t30dg6oj 194 3 is be VBZ cord-104317-t30dg6oj 194 4 a a DT cord-104317-t30dg6oj 194 5 bit bit NN cord-104317-t30dg6oj 194 6 counterintuitive counterintuitive JJ cord-104317-t30dg6oj 194 7 considering considering NN cord-104317-t30dg6oj 194 8 that that IN cord-104317-t30dg6oj 194 9 above above IN cord-104317-t30dg6oj 194 10 I -PRON- PRP cord-104317-t30dg6oj 194 11 discussed discuss VBD cord-104317-t30dg6oj 194 12 that that IN cord-104317-t30dg6oj 194 13 viruses virus NNS cord-104317-t30dg6oj 194 14 are be VBP cord-104317-t30dg6oj 194 15 intrinsically intrinsically RB cord-104317-t30dg6oj 194 16 parasitic parasitic JJ cord-104317-t30dg6oj 194 17 . . . cord-104317-t30dg6oj 195 1 This this DT cord-104317-t30dg6oj 195 2 can can MD cord-104317-t30dg6oj 195 3 be be VB cord-104317-t30dg6oj 195 4 rationalized rationalize VBN cord-104317-t30dg6oj 195 5 with with IN cord-104317-t30dg6oj 195 6 the the DT cord-104317-t30dg6oj 195 7 assertion assertion NN cord-104317-t30dg6oj 195 8 that that IN cord-104317-t30dg6oj 195 9 nearly nearly RB cord-104317-t30dg6oj 195 10 all all DT cord-104317-t30dg6oj 195 11 mutualistic mutualistic JJ cord-104317-t30dg6oj 195 12 interactions interaction NNS cord-104317-t30dg6oj 195 13 were be VBD cord-104317-t30dg6oj 195 14 probably probably RB cord-104317-t30dg6oj 195 15 at at IN cord-104317-t30dg6oj 195 16 some some DT cord-104317-t30dg6oj 195 17 point point NN cord-104317-t30dg6oj 195 18 a a DT cord-104317-t30dg6oj 195 19 form form NN cord-104317-t30dg6oj 195 20 of of IN cord-104317-t30dg6oj 195 21 parasitism parasitism NN cord-104317-t30dg6oj 195 22 , , , cord-104317-t30dg6oj 195 23 then then RB cord-104317-t30dg6oj 195 24 passed pass VBD cord-104317-t30dg6oj 195 25 through through IN cord-104317-t30dg6oj 195 26 a a DT cord-104317-t30dg6oj 195 27 commensal commensal JJ cord-104317-t30dg6oj 195 28 stage stage NN cord-104317-t30dg6oj 195 29 , , , cord-104317-t30dg6oj 195 30 and and CC cord-104317-t30dg6oj 195 31 finally finally RB cord-104317-t30dg6oj 195 32 adjusted adjust VBN cord-104317-t30dg6oj 195 33 to to IN cord-104317-t30dg6oj 195 34 mutualistic mutualistic JJ cord-104317-t30dg6oj 195 35 harmony harmony NN cord-104317-t30dg6oj 195 36 through through IN cord-104317-t30dg6oj 195 37 co co NN cord-104317-t30dg6oj 195 38 - - NN cord-104317-t30dg6oj 195 39 evolution evolution NN cord-104317-t30dg6oj 195 40 . . . cord-104317-t30dg6oj 196 1 This this DT cord-104317-t30dg6oj 196 2 stipulation stipulation NN cord-104317-t30dg6oj 196 3 is be VBZ cord-104317-t30dg6oj 196 4 based base VBN cord-104317-t30dg6oj 196 5 on on IN cord-104317-t30dg6oj 196 6 the the DT cord-104317-t30dg6oj 196 7 reasoning reasoning NN cord-104317-t30dg6oj 196 8 that that IN cord-104317-t30dg6oj 196 9 the the DT cord-104317-t30dg6oj 196 10 amount amount NN cord-104317-t30dg6oj 196 11 of of IN cord-104317-t30dg6oj 196 12 evolutionary evolutionary JJ cord-104317-t30dg6oj 196 13 change change NN cord-104317-t30dg6oj 196 14 necessitated necessitate VBN cord-104317-t30dg6oj 196 15 in in IN cord-104317-t30dg6oj 196 16 the the DT cord-104317-t30dg6oj 196 17 virus virus NN cord-104317-t30dg6oj 196 18 and/or and/or CC cord-104317-t30dg6oj 196 19 the the DT cord-104317-t30dg6oj 196 20 host host NN cord-104317-t30dg6oj 196 21 to to TO cord-104317-t30dg6oj 196 22 switch switch VB cord-104317-t30dg6oj 196 23 interaction interaction NN cord-104317-t30dg6oj 196 24 types type NNS cord-104317-t30dg6oj 196 25 requires require VBZ cord-104317-t30dg6oj 196 26 significant significant JJ cord-104317-t30dg6oj 196 27 adaptation adaptation NN cord-104317-t30dg6oj 196 28 and and CC cord-104317-t30dg6oj 196 29 thus thus RB cord-104317-t30dg6oj 196 30 is be VBZ cord-104317-t30dg6oj 196 31 more more RBR cord-104317-t30dg6oj 196 32 likely likely JJ cord-104317-t30dg6oj 196 33 to to TO cord-104317-t30dg6oj 196 34 proceed proceed VB cord-104317-t30dg6oj 196 35 stepwise stepwise JJ cord-104317-t30dg6oj 196 36 [ [ -LRB- cord-104317-t30dg6oj 196 37 112 112 CD cord-104317-t30dg6oj 196 38 ] ] -RRB- cord-104317-t30dg6oj 196 39 . . . cord-104317-t30dg6oj 197 1 A a DT cord-104317-t30dg6oj 197 2 relationship relationship NN cord-104317-t30dg6oj 197 3 must must MD cord-104317-t30dg6oj 197 4 become become VB cord-104317-t30dg6oj 197 5 sufficiently sufficiently RB cord-104317-t30dg6oj 197 6 non non JJ cord-104317-t30dg6oj 197 7 - - JJ cord-104317-t30dg6oj 197 8 pathogenic pathogenic JJ cord-104317-t30dg6oj 197 9 to to TO cord-104317-t30dg6oj 197 10 allow allow VB cord-104317-t30dg6oj 197 11 interaction interaction NN cord-104317-t30dg6oj 197 12 without without IN cord-104317-t30dg6oj 197 13 rejection rejection NN cord-104317-t30dg6oj 197 14 as as RB cord-104317-t30dg6oj 197 15 well well RB cord-104317-t30dg6oj 197 16 as as IN cord-104317-t30dg6oj 197 17 develop develop VB cord-104317-t30dg6oj 197 18 benefit benefit NN cord-104317-t30dg6oj 197 19 for for IN cord-104317-t30dg6oj 197 20 both both DT cord-104317-t30dg6oj 197 21 sides side NNS cord-104317-t30dg6oj 197 22 , , , cord-104317-t30dg6oj 197 23 and and CC cord-104317-t30dg6oj 197 24 an an DT cord-104317-t30dg6oj 197 25 intermediate intermediate JJ cord-104317-t30dg6oj 197 26 state state NN cord-104317-t30dg6oj 197 27 seems seem VBZ cord-104317-t30dg6oj 197 28 a a DT cord-104317-t30dg6oj 197 29 logical logical JJ cord-104317-t30dg6oj 197 30 platform platform NN cord-104317-t30dg6oj 197 31 for for IN cord-104317-t30dg6oj 197 32 this this DT cord-104317-t30dg6oj 197 33 . . . cord-104317-t30dg6oj 198 1 Indeed indeed RB cord-104317-t30dg6oj 198 2 , , , cord-104317-t30dg6oj 198 3 this this DT cord-104317-t30dg6oj 198 4 postulation postulation NN cord-104317-t30dg6oj 198 5 seems seem VBZ cord-104317-t30dg6oj 198 6 bolstered bolster VBN cord-104317-t30dg6oj 198 7 by by IN cord-104317-t30dg6oj 198 8 the the DT cord-104317-t30dg6oj 198 9 spectrum spectrum NN cord-104317-t30dg6oj 198 10 of of IN cord-104317-t30dg6oj 198 11 mutualistic mutualistic JJ cord-104317-t30dg6oj 198 12 relationships relationship NNS cord-104317-t30dg6oj 198 13 that that WDT cord-104317-t30dg6oj 198 14 exist exist VBP cord-104317-t30dg6oj 198 15 , , , cord-104317-t30dg6oj 198 16 spanning span VBG cord-104317-t30dg6oj 198 17 obligate obligate VBP cord-104317-t30dg6oj 198 18 to to IN cord-104317-t30dg6oj 198 19 conditional conditional JJ cord-104317-t30dg6oj 198 20 mutualistic mutualistic JJ cord-104317-t30dg6oj 198 21 benefits benefit NNS cord-104317-t30dg6oj 198 22 [ [ -LRB- cord-104317-t30dg6oj 198 23 18 18 CD cord-104317-t30dg6oj 198 24 ] ] -RRB- cord-104317-t30dg6oj 198 25 . . . cord-104317-t30dg6oj 199 1 A a DT cord-104317-t30dg6oj 199 2 classic classic JJ cord-104317-t30dg6oj 199 3 non non JJ cord-104317-t30dg6oj 199 4 - - JJ cord-104317-t30dg6oj 199 5 viral viral JJ cord-104317-t30dg6oj 199 6 example example NN cord-104317-t30dg6oj 199 7 that that WDT cord-104317-t30dg6oj 199 8 illustrates illustrate VBZ cord-104317-t30dg6oj 199 9 this this DT cord-104317-t30dg6oj 199 10 point point NN cord-104317-t30dg6oj 199 11 is be VBZ cord-104317-t30dg6oj 199 12 the the DT cord-104317-t30dg6oj 199 13 integration integration NN cord-104317-t30dg6oj 199 14 of of IN cord-104317-t30dg6oj 199 15 the the DT cord-104317-t30dg6oj 199 16 mitochondrion mitochondrion NN cord-104317-t30dg6oj 199 17 into into IN cord-104317-t30dg6oj 199 18 the the DT cord-104317-t30dg6oj 199 19 cells cell NNS cord-104317-t30dg6oj 199 20 of of IN cord-104317-t30dg6oj 199 21 ancient ancient JJ cord-104317-t30dg6oj 199 22 prokaryotes prokaryote NNS cord-104317-t30dg6oj 199 23 or or CC cord-104317-t30dg6oj 199 24 eukaryotes eukaryote NNS cord-104317-t30dg6oj 199 25 . . . cord-104317-t30dg6oj 200 1 This this DT cord-104317-t30dg6oj 200 2 kind kind NN cord-104317-t30dg6oj 200 3 of of IN cord-104317-t30dg6oj 200 4 relationship relationship NN cord-104317-t30dg6oj 200 5 is be VBZ cord-104317-t30dg6oj 200 6 considered consider VBN cord-104317-t30dg6oj 200 7 symbiogenic symbiogenic JJ cord-104317-t30dg6oj 200 8 , , , cord-104317-t30dg6oj 200 9 meaning mean VBG cord-104317-t30dg6oj 200 10 that that IN cord-104317-t30dg6oj 200 11 once once IN cord-104317-t30dg6oj 200 12 separate separate JJ cord-104317-t30dg6oj 200 13 organisms organism NNS cord-104317-t30dg6oj 200 14 have have VBP cord-104317-t30dg6oj 200 15 now now RB cord-104317-t30dg6oj 200 16 fused fuse VBN cord-104317-t30dg6oj 200 17 into into IN cord-104317-t30dg6oj 200 18 a a DT cord-104317-t30dg6oj 200 19 distinct distinct JJ cord-104317-t30dg6oj 200 20 new new JJ cord-104317-t30dg6oj 200 21 species specie NNS cord-104317-t30dg6oj 200 22 [ [ -LRB- cord-104317-t30dg6oj 200 23 18 18 CD cord-104317-t30dg6oj 200 24 ] ] -RRB- cord-104317-t30dg6oj 200 25 . . . cord-104317-t30dg6oj 201 1 Either either CC cord-104317-t30dg6oj 201 2 by by IN cord-104317-t30dg6oj 201 3 phagocytosis phagocytosis NN cord-104317-t30dg6oj 201 4 or or CC cord-104317-t30dg6oj 201 5 infection infection NN cord-104317-t30dg6oj 201 6 , , , cord-104317-t30dg6oj 201 7 an an DT cord-104317-t30dg6oj 201 8 endosymbiosis endosymbiosis NN cord-104317-t30dg6oj 201 9 was be VBD cord-104317-t30dg6oj 201 10 established establish VBN cord-104317-t30dg6oj 201 11 in in IN cord-104317-t30dg6oj 201 12 which which WDT cord-104317-t30dg6oj 201 13 the the DT cord-104317-t30dg6oj 201 14 mitochondrial mitochondrial JJ cord-104317-t30dg6oj 201 15 bacterial bacterial JJ cord-104317-t30dg6oj 201 16 progenitor progenitor NN cord-104317-t30dg6oj 201 17 supplied supply VBD cord-104317-t30dg6oj 201 18 some some DT cord-104317-t30dg6oj 201 19 benefit benefit NN cord-104317-t30dg6oj 201 20 to to IN cord-104317-t30dg6oj 201 21 its -PRON- PRP$ cord-104317-t30dg6oj 201 22 host host NN cord-104317-t30dg6oj 201 23 . . . cord-104317-t30dg6oj 202 1 Millions million NNS cord-104317-t30dg6oj 202 2 of of IN cord-104317-t30dg6oj 202 3 years year NNS cord-104317-t30dg6oj 202 4 later later RB cord-104317-t30dg6oj 202 5 , , , cord-104317-t30dg6oj 202 6 mitochondria mitochondrion NNS cord-104317-t30dg6oj 202 7 are be VBP cord-104317-t30dg6oj 202 8 part part NN cord-104317-t30dg6oj 202 9 of of IN cord-104317-t30dg6oj 202 10 all all DT cord-104317-t30dg6oj 202 11 eukaryotic eukaryotic JJ cord-104317-t30dg6oj 202 12 organisms organism NNS cord-104317-t30dg6oj 202 13 with with IN cord-104317-t30dg6oj 202 14 functions function NNS cord-104317-t30dg6oj 202 15 spanning span VBG cord-104317-t30dg6oj 202 16 energy energy NN cord-104317-t30dg6oj 202 17 production production NN cord-104317-t30dg6oj 202 18 , , , cord-104317-t30dg6oj 202 19 innate innate JJ cord-104317-t30dg6oj 202 20 immunity immunity NN cord-104317-t30dg6oj 202 21 , , , cord-104317-t30dg6oj 202 22 and and CC cord-104317-t30dg6oj 202 23 membrane membrane NN cord-104317-t30dg6oj 202 24 potential potential NN cord-104317-t30dg6oj 202 25 , , , cord-104317-t30dg6oj 202 26 to to TO cord-104317-t30dg6oj 202 27 name name VB cord-104317-t30dg6oj 202 28 a a DT cord-104317-t30dg6oj 202 29 few few JJ cord-104317-t30dg6oj 202 30 [ [ -LRB- cord-104317-t30dg6oj 202 31 113 113 CD cord-104317-t30dg6oj 202 32 , , , cord-104317-t30dg6oj 202 33 114 114 CD cord-104317-t30dg6oj 202 34 ] ] -RRB- cord-104317-t30dg6oj 202 35 . . . cord-104317-t30dg6oj 203 1 It -PRON- PRP cord-104317-t30dg6oj 203 2 is be VBZ cord-104317-t30dg6oj 203 3 now now RB cord-104317-t30dg6oj 203 4 appreciated appreciate VBN cord-104317-t30dg6oj 203 5 from from IN cord-104317-t30dg6oj 203 6 data datum NNS cord-104317-t30dg6oj 203 7 on on IN cord-104317-t30dg6oj 203 8 the the DT cord-104317-t30dg6oj 203 9 microbiome microbiome NN cord-104317-t30dg6oj 203 10 that that WDT cord-104317-t30dg6oj 203 11 it -PRON- PRP cord-104317-t30dg6oj 203 12 would would MD cord-104317-t30dg6oj 203 13 be be VB cord-104317-t30dg6oj 203 14 to to IN cord-104317-t30dg6oj 203 15 the the DT cord-104317-t30dg6oj 203 16 host host NN cord-104317-t30dg6oj 203 17 's 's POS cord-104317-t30dg6oj 203 18 benefit benefit NN cord-104317-t30dg6oj 203 19 if if IN cord-104317-t30dg6oj 203 20 the the DT cord-104317-t30dg6oj 203 21 power power NN cord-104317-t30dg6oj 203 22 of of IN cord-104317-t30dg6oj 203 23 the the DT cord-104317-t30dg6oj 203 24 genetic genetic JJ cord-104317-t30dg6oj 203 25 information information NN cord-104317-t30dg6oj 203 26 in in IN cord-104317-t30dg6oj 203 27 and and CC cord-104317-t30dg6oj 203 28 around around IN cord-104317-t30dg6oj 203 29 them -PRON- PRP cord-104317-t30dg6oj 203 30 could could MD cord-104317-t30dg6oj 203 31 be be VB cord-104317-t30dg6oj 203 32 harnessed harness VBN cord-104317-t30dg6oj 203 33 as as IN cord-104317-t30dg6oj 203 34 an an DT cord-104317-t30dg6oj 203 35 evolutionary evolutionary NN cord-104317-t30dg6oj 203 36 ( ( -LRB- cord-104317-t30dg6oj 203 37 and and CC cord-104317-t30dg6oj 203 38 medical medical JJ cord-104317-t30dg6oj 203 39 ) ) -RRB- cord-104317-t30dg6oj 203 40 tool tool NN cord-104317-t30dg6oj 203 41 for for IN cord-104317-t30dg6oj 203 42 self self NN cord-104317-t30dg6oj 203 43 - - HYPH cord-104317-t30dg6oj 203 44 betterment betterment NN cord-104317-t30dg6oj 203 45 [ [ -LRB- cord-104317-t30dg6oj 203 46 115 115 CD cord-104317-t30dg6oj 203 47 ] ] -RRB- cord-104317-t30dg6oj 203 48 [ [ -LRB- cord-104317-t30dg6oj 203 49 116 116 CD cord-104317-t30dg6oj 203 50 ] ] -RRB- cord-104317-t30dg6oj 203 51 [ [ -LRB- cord-104317-t30dg6oj 203 52 117 117 CD cord-104317-t30dg6oj 203 53 ] ] -RRB- cord-104317-t30dg6oj 203 54 . . . cord-104317-t30dg6oj 204 1 This this DT cord-104317-t30dg6oj 204 2 could could MD cord-104317-t30dg6oj 204 3 occur occur VB cord-104317-t30dg6oj 204 4 in in IN cord-104317-t30dg6oj 204 5 a a DT cord-104317-t30dg6oj 204 6 number number NN cord-104317-t30dg6oj 204 7 of of IN cord-104317-t30dg6oj 204 8 ways way NNS cord-104317-t30dg6oj 204 9 , , , cord-104317-t30dg6oj 204 10 either either CC cord-104317-t30dg6oj 204 11 through through IN cord-104317-t30dg6oj 204 12 encouraging encourage VBG cord-104317-t30dg6oj 204 13 colonization colonization NN cord-104317-t30dg6oj 204 14 by by IN cord-104317-t30dg6oj 204 15 beneficial beneficial JJ cord-104317-t30dg6oj 204 16 microbes microbe NNS cord-104317-t30dg6oj 204 17 or or CC cord-104317-t30dg6oj 204 18 even even RB cord-104317-t30dg6oj 204 19 by by IN cord-104317-t30dg6oj 204 20 integrating integrate VBG cord-104317-t30dg6oj 204 21 the the DT cord-104317-t30dg6oj 204 22 genetic genetic JJ cord-104317-t30dg6oj 204 23 material material NN cord-104317-t30dg6oj 204 24 of of IN cord-104317-t30dg6oj 204 25 these these DT cord-104317-t30dg6oj 204 26 microbes microbe NNS cord-104317-t30dg6oj 204 27 into into IN cord-104317-t30dg6oj 204 28 the the DT cord-104317-t30dg6oj 204 29 human human JJ cord-104317-t30dg6oj 204 30 genome genome NN cord-104317-t30dg6oj 204 31 . . . cord-104317-t30dg6oj 205 1 A a DT cord-104317-t30dg6oj 205 2 small small JJ cord-104317-t30dg6oj 205 3 body body NN cord-104317-t30dg6oj 205 4 of of IN cord-104317-t30dg6oj 205 5 literature literature NN cord-104317-t30dg6oj 205 6 characterizing characterize VBG cord-104317-t30dg6oj 205 7 virus virus NN cord-104317-t30dg6oj 205 8 - - HYPH cord-104317-t30dg6oj 205 9 human human JJ cord-104317-t30dg6oj 205 10 mutualism mutualism NN cord-104317-t30dg6oj 205 11 has have VBZ cord-104317-t30dg6oj 205 12 given give VBN cord-104317-t30dg6oj 205 13 a a DT cord-104317-t30dg6oj 205 14 glimpse glimpse NN cord-104317-t30dg6oj 205 15 into into IN cord-104317-t30dg6oj 205 16 this this DT cord-104317-t30dg6oj 205 17 facet facet NN cord-104317-t30dg6oj 205 18 of of IN cord-104317-t30dg6oj 205 19 the the DT cord-104317-t30dg6oj 205 20 virome virome NN cord-104317-t30dg6oj 205 21 . . . cord-104317-t30dg6oj 206 1 In in IN cord-104317-t30dg6oj 206 2 the the DT cord-104317-t30dg6oj 206 3 next next JJ cord-104317-t30dg6oj 206 4 sections section NNS cord-104317-t30dg6oj 206 5 , , , cord-104317-t30dg6oj 206 6 I -PRON- PRP cord-104317-t30dg6oj 206 7 will will MD cord-104317-t30dg6oj 206 8 review review VB cord-104317-t30dg6oj 206 9 two two CD cord-104317-t30dg6oj 206 10 levels level NNS cord-104317-t30dg6oj 206 11 of of IN cord-104317-t30dg6oj 206 12 symbiotic symbiotic JJ cord-104317-t30dg6oj 206 13 relationships relationship NNS cord-104317-t30dg6oj 206 14 and and CC cord-104317-t30dg6oj 206 15 discuss discuss VB cord-104317-t30dg6oj 206 16 important important JJ cord-104317-t30dg6oj 206 17 gaps gap NNS cord-104317-t30dg6oj 206 18 in in IN cord-104317-t30dg6oj 206 19 knowledge knowledge NN cord-104317-t30dg6oj 206 20 important important JJ cord-104317-t30dg6oj 206 21 for for IN cord-104317-t30dg6oj 206 22 the the DT cord-104317-t30dg6oj 206 23 understanding understanding NN cord-104317-t30dg6oj 206 24 and and CC cord-104317-t30dg6oj 206 25 possible possible JJ cord-104317-t30dg6oj 206 26 utilization utilization NN cord-104317-t30dg6oj 206 27 of of IN cord-104317-t30dg6oj 206 28 these these DT cord-104317-t30dg6oj 206 29 interactions interaction NNS cord-104317-t30dg6oj 206 30 for for IN cord-104317-t30dg6oj 206 31 human human JJ cord-104317-t30dg6oj 206 32 health health NN cord-104317-t30dg6oj 206 33 . . . cord-104317-t30dg6oj 207 1 Symbiotic symbiotic JJ cord-104317-t30dg6oj 207 2 viruses virus NNS cord-104317-t30dg6oj 207 3 that that WDT cord-104317-t30dg6oj 207 4 are be VBP cord-104317-t30dg6oj 207 5 transmitted transmit VBN cord-104317-t30dg6oj 207 6 vertically vertically RB cord-104317-t30dg6oj 207 7 from from IN cord-104317-t30dg6oj 207 8 parent parent NN cord-104317-t30dg6oj 207 9 to to IN cord-104317-t30dg6oj 207 10 child child NN cord-104317-t30dg6oj 207 11 in in IN cord-104317-t30dg6oj 207 12 the the DT cord-104317-t30dg6oj 207 13 germ germ NN cord-104317-t30dg6oj 207 14 line line NN cord-104317-t30dg6oj 207 15 are be VBP cord-104317-t30dg6oj 207 16 considered consider VBN cord-104317-t30dg6oj 207 17 primary primary JJ cord-104317-t30dg6oj 207 18 symbionts symbiont NNS cord-104317-t30dg6oj 207 19 [ [ -LRB- cord-104317-t30dg6oj 207 20 118 118 CD cord-104317-t30dg6oj 207 21 ] ] -RRB- cord-104317-t30dg6oj 207 22 . . . cord-104317-t30dg6oj 208 1 These these DT cord-104317-t30dg6oj 208 2 relationships relationship NNS cord-104317-t30dg6oj 208 3 are be VBP cord-104317-t30dg6oj 208 4 often often RB cord-104317-t30dg6oj 208 5 ancient ancient JJ cord-104317-t30dg6oj 208 6 and and CC cord-104317-t30dg6oj 208 7 obligate obligate VB cord-104317-t30dg6oj 208 8 for for IN cord-104317-t30dg6oj 208 9 both both DT cord-104317-t30dg6oj 208 10 parties party NNS cord-104317-t30dg6oj 208 11 [ [ -LRB- cord-104317-t30dg6oj 208 12 119 119 CD cord-104317-t30dg6oj 208 13 ] ] -RRB- cord-104317-t30dg6oj 208 14 . . . cord-104317-t30dg6oj 209 1 The the DT cord-104317-t30dg6oj 209 2 most most RBS cord-104317-t30dg6oj 209 3 obvious obvious JJ cord-104317-t30dg6oj 209 4 example example NN cord-104317-t30dg6oj 209 5 is be VBZ cord-104317-t30dg6oj 209 6 the the DT cord-104317-t30dg6oj 209 7 EREs ere NNS cord-104317-t30dg6oj 209 8 that that WDT cord-104317-t30dg6oj 209 9 have have VBP cord-104317-t30dg6oj 209 10 integrated integrate VBN cord-104317-t30dg6oj 209 11 themselves -PRON- PRP cord-104317-t30dg6oj 209 12 into into IN cord-104317-t30dg6oj 209 13 human human JJ cord-104317-t30dg6oj 209 14 genomes genome NNS cord-104317-t30dg6oj 209 15 at at IN cord-104317-t30dg6oj 209 16 many many JJ cord-104317-t30dg6oj 209 17 points point NNS cord-104317-t30dg6oj 209 18 throughout throughout IN cord-104317-t30dg6oj 209 19 millions million NNS cord-104317-t30dg6oj 209 20 of of IN cord-104317-t30dg6oj 209 21 years year NNS cord-104317-t30dg6oj 209 22 of of IN cord-104317-t30dg6oj 209 23 evolution evolution NN cord-104317-t30dg6oj 209 24 . . . cord-104317-t30dg6oj 210 1 While while IN cord-104317-t30dg6oj 210 2 some some DT cord-104317-t30dg6oj 210 3 have have VBP cord-104317-t30dg6oj 210 4 been be VBN cord-104317-t30dg6oj 210 5 inactivated inactivate VBN cord-104317-t30dg6oj 210 6 by by IN cord-104317-t30dg6oj 210 7 recombination recombination NN cord-104317-t30dg6oj 210 8 , , , cord-104317-t30dg6oj 210 9 deletions deletion NNS cord-104317-t30dg6oj 210 10 , , , cord-104317-t30dg6oj 210 11 and and CC cord-104317-t30dg6oj 210 12 random random JJ cord-104317-t30dg6oj 210 13 mutations mutation NNS cord-104317-t30dg6oj 210 14 , , , cord-104317-t30dg6oj 210 15 many many JJ cord-104317-t30dg6oj 210 16 still still RB cord-104317-t30dg6oj 210 17 appear appear VBP cord-104317-t30dg6oj 210 18 to to TO cord-104317-t30dg6oj 210 19 be be VB cord-104317-t30dg6oj 210 20 expressed express VBN cord-104317-t30dg6oj 210 21 [ [ -LRB- cord-104317-t30dg6oj 210 22 65 65 CD cord-104317-t30dg6oj 210 23 ] ] -RRB- cord-104317-t30dg6oj 210 24 . . . cord-104317-t30dg6oj 211 1 It -PRON- PRP cord-104317-t30dg6oj 211 2 is be VBZ cord-104317-t30dg6oj 211 3 also also RB cord-104317-t30dg6oj 211 4 obvious obvious JJ cord-104317-t30dg6oj 211 5 the the DT cord-104317-t30dg6oj 211 6 control control NN cord-104317-t30dg6oj 211 7 of of IN cord-104317-t30dg6oj 211 8 these these DT cord-104317-t30dg6oj 211 9 elements element NNS cord-104317-t30dg6oj 211 10 is be VBZ cord-104317-t30dg6oj 211 11 an an DT cord-104317-t30dg6oj 211 12 important important JJ cord-104317-t30dg6oj 211 13 challenge challenge NN cord-104317-t30dg6oj 211 14 for for IN cord-104317-t30dg6oj 211 15 the the DT cord-104317-t30dg6oj 211 16 host host NN cord-104317-t30dg6oj 211 17 , , , cord-104317-t30dg6oj 211 18 as as IN cord-104317-t30dg6oj 211 19 many many JJ cord-104317-t30dg6oj 211 20 strategies strategy NNS cord-104317-t30dg6oj 211 21 have have VBP cord-104317-t30dg6oj 211 22 evolved evolve VBN cord-104317-t30dg6oj 211 23 to to TO cord-104317-t30dg6oj 211 24 control control VB cord-104317-t30dg6oj 211 25 replication replication NN cord-104317-t30dg6oj 211 26 and and CC cord-104317-t30dg6oj 211 27 reinfection reinfection NN cord-104317-t30dg6oj 211 28 of of IN cord-104317-t30dg6oj 211 29 inserted insert VBN cord-104317-t30dg6oj 211 30 EREs ere NNS cord-104317-t30dg6oj 211 31 [ [ -LRB- cord-104317-t30dg6oj 211 32 120 120 CD cord-104317-t30dg6oj 211 33 , , , cord-104317-t30dg6oj 211 34 121 121 CD cord-104317-t30dg6oj 211 35 ] ] -RRB- cord-104317-t30dg6oj 211 36 . . . cord-104317-t30dg6oj 212 1 To to IN cord-104317-t30dg6oj 212 2 date date NN cord-104317-t30dg6oj 212 3 , , , cord-104317-t30dg6oj 212 4 the the DT cord-104317-t30dg6oj 212 5 role role NN cord-104317-t30dg6oj 212 6 of of IN cord-104317-t30dg6oj 212 7 most most JJS cord-104317-t30dg6oj 212 8 EREs ere NNS cord-104317-t30dg6oj 212 9 in in IN cord-104317-t30dg6oj 212 10 the the DT cord-104317-t30dg6oj 212 11 human human JJ cord-104317-t30dg6oj 212 12 genome genome NN cord-104317-t30dg6oj 212 13 is be VBZ cord-104317-t30dg6oj 212 14 unknown unknown JJ cord-104317-t30dg6oj 212 15 , , , cord-104317-t30dg6oj 212 16 but but CC cord-104317-t30dg6oj 212 17 a a DT cord-104317-t30dg6oj 212 18 few few JJ cord-104317-t30dg6oj 212 19 human human JJ cord-104317-t30dg6oj 212 20 and and CC cord-104317-t30dg6oj 212 21 mammalian mammalian JJ cord-104317-t30dg6oj 212 22 examples example NNS cord-104317-t30dg6oj 212 23 indicate indicate VBP cord-104317-t30dg6oj 212 24 that that IN cord-104317-t30dg6oj 212 25 their -PRON- PRP$ cord-104317-t30dg6oj 212 26 presence presence NN cord-104317-t30dg6oj 212 27 confers confer VBZ cord-104317-t30dg6oj 212 28 a a DT cord-104317-t30dg6oj 212 29 number number NN cord-104317-t30dg6oj 212 30 of of IN cord-104317-t30dg6oj 212 31 benefits benefit NNS cord-104317-t30dg6oj 212 32 . . . cord-104317-t30dg6oj 213 1 Some some DT cord-104317-t30dg6oj 213 2 of of IN cord-104317-t30dg6oj 213 3 the the DT cord-104317-t30dg6oj 213 4 most most RBS cord-104317-t30dg6oj 213 5 important important JJ cord-104317-t30dg6oj 213 6 effects effect NNS cord-104317-t30dg6oj 213 7 of of IN cord-104317-t30dg6oj 213 8 ERE ERE NNP cord-104317-t30dg6oj 213 9 colonization colonization NN cord-104317-t30dg6oj 213 10 come come VBP cord-104317-t30dg6oj 213 11 in in IN cord-104317-t30dg6oj 213 12 the the DT cord-104317-t30dg6oj 213 13 form form NN cord-104317-t30dg6oj 213 14 of of IN cord-104317-t30dg6oj 213 15 genomic genomic JJ cord-104317-t30dg6oj 213 16 diversity diversity NN cord-104317-t30dg6oj 213 17 and and CC cord-104317-t30dg6oj 213 18 plasticity plasticity NN cord-104317-t30dg6oj 213 19 . . . cord-104317-t30dg6oj 214 1 EREs EREs NNP cord-104317-t30dg6oj 214 2 can can MD cord-104317-t30dg6oj 214 3 not not RB cord-104317-t30dg6oj 214 4 only only RB cord-104317-t30dg6oj 214 5 insert insert VB cord-104317-t30dg6oj 214 6 new new JJ cord-104317-t30dg6oj 214 7 genetic genetic JJ cord-104317-t30dg6oj 214 8 material material NN cord-104317-t30dg6oj 214 9 , , , cord-104317-t30dg6oj 214 10 including include VBG cord-104317-t30dg6oj 214 11 protein protein NN cord-104317-t30dg6oj 214 12 coding coding NN cord-104317-t30dg6oj 214 13 genes gene NNS cord-104317-t30dg6oj 214 14 , , , cord-104317-t30dg6oj 214 15 but but CC cord-104317-t30dg6oj 214 16 also also RB cord-104317-t30dg6oj 214 17 play play VBP cord-104317-t30dg6oj 214 18 roles role NNS cord-104317-t30dg6oj 214 19 in in IN cord-104317-t30dg6oj 214 20 genetic genetic JJ cord-104317-t30dg6oj 214 21 mobility mobility NN cord-104317-t30dg6oj 214 22 and and CC cord-104317-t30dg6oj 214 23 control control NN cord-104317-t30dg6oj 214 24 . . . cord-104317-t30dg6oj 215 1 The the DT cord-104317-t30dg6oj 215 2 recombinatorial recombinatorial JJ cord-104317-t30dg6oj 215 3 ability ability NN cord-104317-t30dg6oj 215 4 of of IN cord-104317-t30dg6oj 215 5 EREs EREs NNP cord-104317-t30dg6oj 215 6 is be VBZ cord-104317-t30dg6oj 215 7 conferred confer VBN cord-104317-t30dg6oj 215 8 upon upon IN cord-104317-t30dg6oj 215 9 insertion insertion NN cord-104317-t30dg6oj 215 10 and and CC cord-104317-t30dg6oj 215 11 has have VBZ cord-104317-t30dg6oj 215 12 facilitated facilitate VBN cord-104317-t30dg6oj 215 13 recombination recombination NN cord-104317-t30dg6oj 215 14 and and CC cord-104317-t30dg6oj 215 15 duplication duplication NN cord-104317-t30dg6oj 215 16 of of IN cord-104317-t30dg6oj 215 17 large large JJ cord-104317-t30dg6oj 215 18 swathes swathe NNS cord-104317-t30dg6oj 215 19 of of IN cord-104317-t30dg6oj 215 20 genomic genomic JJ cord-104317-t30dg6oj 215 21 material material NN cord-104317-t30dg6oj 215 22 [ [ -LRB- cord-104317-t30dg6oj 215 23 122 122 CD cord-104317-t30dg6oj 215 24 , , , cord-104317-t30dg6oj 215 25 123 123 CD cord-104317-t30dg6oj 215 26 ] ] -RRB- cord-104317-t30dg6oj 215 27 . . . cord-104317-t30dg6oj 216 1 Where where WRB cord-104317-t30dg6oj 216 2 an an DT cord-104317-t30dg6oj 216 3 ERE ERE NNP cord-104317-t30dg6oj 216 4 inserts insert VBZ cord-104317-t30dg6oj 216 5 itself -PRON- PRP cord-104317-t30dg6oj 216 6 can can MD cord-104317-t30dg6oj 216 7 be be VB cord-104317-t30dg6oj 216 8 an an DT cord-104317-t30dg6oj 216 9 important important JJ cord-104317-t30dg6oj 216 10 factor factor NN cord-104317-t30dg6oj 216 11 in in IN cord-104317-t30dg6oj 216 12 how how WRB cord-104317-t30dg6oj 216 13 it -PRON- PRP cord-104317-t30dg6oj 216 14 affects affect VBZ cord-104317-t30dg6oj 216 15 the the DT cord-104317-t30dg6oj 216 16 genome genome NN cord-104317-t30dg6oj 216 17 , , , cord-104317-t30dg6oj 216 18 as as IN cord-104317-t30dg6oj 216 19 insertion insertion NN cord-104317-t30dg6oj 216 20 into into IN cord-104317-t30dg6oj 216 21 a a DT cord-104317-t30dg6oj 216 22 protein protein NN cord-104317-t30dg6oj 216 23 coding coding NN cord-104317-t30dg6oj 216 24 gene gene NN cord-104317-t30dg6oj 216 25 could could MD cord-104317-t30dg6oj 216 26 be be VB cord-104317-t30dg6oj 216 27 innocuous innocuous JJ cord-104317-t30dg6oj 216 28 or or CC cord-104317-t30dg6oj 216 29 catastrophic catastrophic JJ cord-104317-t30dg6oj 216 30 . . . cord-104317-t30dg6oj 217 1 Alternatively alternatively RB cord-104317-t30dg6oj 217 2 , , , cord-104317-t30dg6oj 217 3 insertion insertion NN cord-104317-t30dg6oj 217 4 in in IN cord-104317-t30dg6oj 217 5 or or CC cord-104317-t30dg6oj 217 6 near near IN cord-104317-t30dg6oj 217 7 promotion promotion NN cord-104317-t30dg6oj 217 8 and and CC cord-104317-t30dg6oj 217 9 regulatory regulatory JJ cord-104317-t30dg6oj 217 10 elements element NNS cord-104317-t30dg6oj 217 11 can can MD cord-104317-t30dg6oj 217 12 result result VB cord-104317-t30dg6oj 217 13 in in IN cord-104317-t30dg6oj 217 14 changes change NNS cord-104317-t30dg6oj 217 15 in in IN cord-104317-t30dg6oj 217 16 transcriptional transcriptional JJ cord-104317-t30dg6oj 217 17 control control NN cord-104317-t30dg6oj 217 18 [ [ -LRB- cord-104317-t30dg6oj 217 19 124 124 CD cord-104317-t30dg6oj 217 20 ] ] -RRB- cord-104317-t30dg6oj 217 21 , , , cord-104317-t30dg6oj 217 22 as as IN cord-104317-t30dg6oj 217 23 can can MD cord-104317-t30dg6oj 217 24 the the DT cord-104317-t30dg6oj 217 25 native native JJ cord-104317-t30dg6oj 217 26 regulatory regulatory JJ cord-104317-t30dg6oj 217 27 sequences sequence NNS cord-104317-t30dg6oj 217 28 in in IN cord-104317-t30dg6oj 217 29 the the DT cord-104317-t30dg6oj 217 30 EREs ere NNS cord-104317-t30dg6oj 217 31 themselves -PRON- PRP cord-104317-t30dg6oj 217 32 [ [ -LRB- cord-104317-t30dg6oj 217 33 125 125 CD cord-104317-t30dg6oj 217 34 , , , cord-104317-t30dg6oj 217 35 126 126 CD cord-104317-t30dg6oj 217 36 ] ] -RRB- cord-104317-t30dg6oj 217 37 . . . cord-104317-t30dg6oj 218 1 Of of RB cord-104317-t30dg6oj 218 2 course course RB cord-104317-t30dg6oj 218 3 , , , cord-104317-t30dg6oj 218 4 all all DT cord-104317-t30dg6oj 218 5 of of IN cord-104317-t30dg6oj 218 6 these these DT cord-104317-t30dg6oj 218 7 benefits benefit NNS cord-104317-t30dg6oj 218 8 can can MD cord-104317-t30dg6oj 218 9 have have VB cord-104317-t30dg6oj 218 10 similarly similarly RB cord-104317-t30dg6oj 218 11 damaging damaging JJ cord-104317-t30dg6oj 218 12 consequences consequence NNS cord-104317-t30dg6oj 218 13 , , , cord-104317-t30dg6oj 218 14 as as IN cord-104317-t30dg6oj 218 15 destabilization destabilization NN cord-104317-t30dg6oj 218 16 of of IN cord-104317-t30dg6oj 218 17 the the DT cord-104317-t30dg6oj 218 18 genome genome NN cord-104317-t30dg6oj 218 19 or or CC cord-104317-t30dg6oj 218 20 particular particular JJ cord-104317-t30dg6oj 218 21 genes gene NNS cord-104317-t30dg6oj 218 22 could could MD cord-104317-t30dg6oj 218 23 have have VB cord-104317-t30dg6oj 218 24 profound profound JJ cord-104317-t30dg6oj 218 25 negative negative JJ cord-104317-t30dg6oj 218 26 effects effect NNS cord-104317-t30dg6oj 218 27 on on IN cord-104317-t30dg6oj 218 28 the the DT cord-104317-t30dg6oj 218 29 host host NN cord-104317-t30dg6oj 218 30 ( ( -LRB- cord-104317-t30dg6oj 218 31 see see VB cord-104317-t30dg6oj 218 32 Atypically atypically RB cord-104317-t30dg6oj 218 33 Pathogenic pathogenic JJ cord-104317-t30dg6oj 218 34 Viruses Viruses NNPS cord-104317-t30dg6oj 218 35 , , , cord-104317-t30dg6oj 218 36 above above RB cord-104317-t30dg6oj 218 37 ) ) -RRB- cord-104317-t30dg6oj 218 38 . . . cord-104317-t30dg6oj 219 1 However however RB cord-104317-t30dg6oj 219 2 , , , cord-104317-t30dg6oj 219 3 natural natural JJ cord-104317-t30dg6oj 219 4 selection selection NN cord-104317-t30dg6oj 219 5 dictates dictate VBZ cord-104317-t30dg6oj 219 6 such such JJ cord-104317-t30dg6oj 219 7 effects effect NNS cord-104317-t30dg6oj 219 8 will will MD cord-104317-t30dg6oj 219 9 not not RB cord-104317-t30dg6oj 219 10 successfully successfully RB cord-104317-t30dg6oj 219 11 continue continue VB cord-104317-t30dg6oj 219 12 in in IN cord-104317-t30dg6oj 219 13 the the DT cord-104317-t30dg6oj 219 14 host host NN cord-104317-t30dg6oj 219 15 lineage lineage NN cord-104317-t30dg6oj 219 16 . . . cord-104317-t30dg6oj 220 1 EREs EREs NNP cord-104317-t30dg6oj 220 2 also also RB cord-104317-t30dg6oj 220 3 have have VBP cord-104317-t30dg6oj 220 4 important important JJ cord-104317-t30dg6oj 220 5 immunologic immunologic JJ cord-104317-t30dg6oj 220 6 and and CC cord-104317-t30dg6oj 220 7 developmental developmental JJ cord-104317-t30dg6oj 220 8 roles role NNS cord-104317-t30dg6oj 220 9 . . . cord-104317-t30dg6oj 221 1 Building build VBG cord-104317-t30dg6oj 221 2 off off IN cord-104317-t30dg6oj 221 3 of of IN cord-104317-t30dg6oj 221 4 the the DT cord-104317-t30dg6oj 221 5 transcriptional transcriptional JJ cord-104317-t30dg6oj 221 6 control control NN cord-104317-t30dg6oj 221 7 effects effect NNS cord-104317-t30dg6oj 221 8 mentioned mention VBN cord-104317-t30dg6oj 221 9 in in IN cord-104317-t30dg6oj 221 10 the the DT cord-104317-t30dg6oj 221 11 last last JJ cord-104317-t30dg6oj 221 12 paragraph paragraph NN cord-104317-t30dg6oj 221 13 , , , cord-104317-t30dg6oj 221 14 EREs ere NNS cord-104317-t30dg6oj 221 15 appear appear VBP cord-104317-t30dg6oj 221 16 to to TO cord-104317-t30dg6oj 221 17 have have VB cord-104317-t30dg6oj 221 18 a a DT cord-104317-t30dg6oj 221 19 role role NN cord-104317-t30dg6oj 221 20 in in IN cord-104317-t30dg6oj 221 21 gene gene NN cord-104317-t30dg6oj 221 22 upregulation upregulation NN cord-104317-t30dg6oj 221 23 via via IN cord-104317-t30dg6oj 221 24 pattern pattern NN cord-104317-t30dg6oj 221 25 recognition recognition NN cord-104317-t30dg6oj 221 26 during during IN cord-104317-t30dg6oj 221 27 the the DT cord-104317-t30dg6oj 221 28 initiation initiation NN cord-104317-t30dg6oj 221 29 of of IN cord-104317-t30dg6oj 221 30 adaptive adaptive JJ cord-104317-t30dg6oj 221 31 immune immune JJ cord-104317-t30dg6oj 221 32 responses response NNS cord-104317-t30dg6oj 221 33 [ [ -LRB- cord-104317-t30dg6oj 221 34 127 127 CD cord-104317-t30dg6oj 221 35 , , , cord-104317-t30dg6oj 221 36 128 128 CD cord-104317-t30dg6oj 221 37 ] ] -RRB- cord-104317-t30dg6oj 221 38 . . . cord-104317-t30dg6oj 222 1 Adaptive adaptive JJ cord-104317-t30dg6oj 222 2 responses response NNS cord-104317-t30dg6oj 222 3 to to IN cord-104317-t30dg6oj 222 4 EREs ere NNS cord-104317-t30dg6oj 222 5 can can MD cord-104317-t30dg6oj 222 6 also also RB cord-104317-t30dg6oj 222 7 play play VB cord-104317-t30dg6oj 222 8 a a DT cord-104317-t30dg6oj 222 9 role role NN cord-104317-t30dg6oj 222 10 in in IN cord-104317-t30dg6oj 222 11 restricting restrict VBG cord-104317-t30dg6oj 222 12 viruses virus NNS cord-104317-t30dg6oj 222 13 by by IN cord-104317-t30dg6oj 222 14 neutralizing neutralize VBG cord-104317-t30dg6oj 222 15 incoming incoming JJ cord-104317-t30dg6oj 222 16 exogenous exogenous JJ cord-104317-t30dg6oj 222 17 virus virus NN cord-104317-t30dg6oj 222 18 via via IN cord-104317-t30dg6oj 222 19 antibody antibody NN cord-104317-t30dg6oj 222 20 development development NN cord-104317-t30dg6oj 222 21 against against IN cord-104317-t30dg6oj 222 22 ERE ERE NNP cord-104317-t30dg6oj 222 23 surface surface NN cord-104317-t30dg6oj 222 24 glycoprotein glycoprotein NN cord-104317-t30dg6oj 222 25 antigens antigen NNS cord-104317-t30dg6oj 222 26 [ [ -LRB- cord-104317-t30dg6oj 222 27 129 129 CD cord-104317-t30dg6oj 222 28 ] ] -RRB- cord-104317-t30dg6oj 222 29 . . . cord-104317-t30dg6oj 223 1 Examples example NNS cord-104317-t30dg6oj 223 2 from from IN cord-104317-t30dg6oj 223 3 mice mouse NNS cord-104317-t30dg6oj 223 4 also also RB cord-104317-t30dg6oj 223 5 indicate indicate VBP cord-104317-t30dg6oj 223 6 that that IN cord-104317-t30dg6oj 223 7 the the DT cord-104317-t30dg6oj 223 8 expression expression NN cord-104317-t30dg6oj 223 9 of of IN cord-104317-t30dg6oj 223 10 the the DT cord-104317-t30dg6oj 223 11 ERV ERV NNP cord-104317-t30dg6oj 223 12 glycoprotein glycoprotein NN cord-104317-t30dg6oj 223 13 env env NN cord-104317-t30dg6oj 223 14 can can MD cord-104317-t30dg6oj 223 15 competitively competitively RB cord-104317-t30dg6oj 223 16 bind bind VB cord-104317-t30dg6oj 223 17 surface surface NN cord-104317-t30dg6oj 223 18 receptors receptor NNS cord-104317-t30dg6oj 223 19 important important JJ cord-104317-t30dg6oj 223 20 for for IN cord-104317-t30dg6oj 223 21 exogenous exogenous JJ cord-104317-t30dg6oj 223 22 virus virus NN cord-104317-t30dg6oj 223 23 entry entry NN cord-104317-t30dg6oj 223 24 and and CC cord-104317-t30dg6oj 223 25 that that IN cord-104317-t30dg6oj 223 26 a a DT cord-104317-t30dg6oj 223 27 short short JJ cord-104317-t30dg6oj 223 28 product product NN cord-104317-t30dg6oj 223 29 of of IN cord-104317-t30dg6oj 223 30 an an DT cord-104317-t30dg6oj 223 31 ERV ERV NNP cord-104317-t30dg6oj 223 32 gag gag NN cord-104317-t30dg6oj 223 33 gene gene NN cord-104317-t30dg6oj 223 34 can can MD cord-104317-t30dg6oj 223 35 inhibit inhibit VB cord-104317-t30dg6oj 223 36 the the DT cord-104317-t30dg6oj 223 37 nuclear nuclear JJ cord-104317-t30dg6oj 223 38 translocation translocation NN cord-104317-t30dg6oj 223 39 of of IN cord-104317-t30dg6oj 223 40 incoming incoming JJ cord-104317-t30dg6oj 223 41 capsids capsid NNS cord-104317-t30dg6oj 223 42 . . . cord-104317-t30dg6oj 224 1 [ [ -LRB- cord-104317-t30dg6oj 224 2 130 130 CD cord-104317-t30dg6oj 224 3 , , , cord-104317-t30dg6oj 224 4 131 131 CD cord-104317-t30dg6oj 224 5 ] ] -RRB- cord-104317-t30dg6oj 224 6 . . . cord-104317-t30dg6oj 225 1 Developmentally developmentally RB cord-104317-t30dg6oj 225 2 , , , cord-104317-t30dg6oj 225 3 the the DT cord-104317-t30dg6oj 225 4 acquisition acquisition NN cord-104317-t30dg6oj 225 5 of of IN cord-104317-t30dg6oj 225 6 ERV ERV NNP cord-104317-t30dg6oj 225 7 syncytins syncytins NNP cord-104317-t30dg6oj 225 8 has have VBZ cord-104317-t30dg6oj 225 9 been be VBN cord-104317-t30dg6oj 225 10 a a DT cord-104317-t30dg6oj 225 11 critical critical JJ cord-104317-t30dg6oj 225 12 step step NN cord-104317-t30dg6oj 225 13 in in IN cord-104317-t30dg6oj 225 14 the the DT cord-104317-t30dg6oj 225 15 evolution evolution NN cord-104317-t30dg6oj 225 16 of of IN cord-104317-t30dg6oj 225 17 placentation placentation NN cord-104317-t30dg6oj 225 18 in in IN cord-104317-t30dg6oj 225 19 humans human NNS cord-104317-t30dg6oj 225 20 [ [ -LRB- cord-104317-t30dg6oj 225 21 27 27 CD cord-104317-t30dg6oj 225 22 , , , cord-104317-t30dg6oj 225 23 132 132 CD cord-104317-t30dg6oj 225 24 , , , cord-104317-t30dg6oj 225 25 133 133 CD cord-104317-t30dg6oj 225 26 ] ] -RRB- cord-104317-t30dg6oj 225 27 . . . cord-104317-t30dg6oj 226 1 The the DT cord-104317-t30dg6oj 226 2 presence presence NN cord-104317-t30dg6oj 226 3 of of IN cord-104317-t30dg6oj 226 4 retroviral retroviral JJ cord-104317-t30dg6oj 226 5 nucleic nucleic JJ cord-104317-t30dg6oj 226 6 acids acid NNS cord-104317-t30dg6oj 226 7 in in IN cord-104317-t30dg6oj 226 8 human human JJ cord-104317-t30dg6oj 226 9 cells cell NNS cord-104317-t30dg6oj 226 10 also also RB cord-104317-t30dg6oj 226 11 suggests suggest VBZ cord-104317-t30dg6oj 226 12 that that IN cord-104317-t30dg6oj 226 13 ERE ERE NNP cord-104317-t30dg6oj 226 14 reverse reverse NN cord-104317-t30dg6oj 226 15 transcription transcription NN cord-104317-t30dg6oj 226 16 may may MD cord-104317-t30dg6oj 226 17 be be VB cord-104317-t30dg6oj 226 18 able able JJ cord-104317-t30dg6oj 226 19 to to TO cord-104317-t30dg6oj 226 20 activate activate VB cord-104317-t30dg6oj 226 21 host host NN cord-104317-t30dg6oj 226 22 innate innate JJ cord-104317-t30dg6oj 226 23 immunity immunity NN cord-104317-t30dg6oj 226 24 [ [ -LRB- cord-104317-t30dg6oj 226 25 62 62 CD cord-104317-t30dg6oj 226 26 ] ] -RRB- cord-104317-t30dg6oj 226 27 . . . cord-104317-t30dg6oj 227 1 Whether whether IN cord-104317-t30dg6oj 227 2 humans human NNS cord-104317-t30dg6oj 227 3 can can MD cord-104317-t30dg6oj 227 4 harness harness VB cord-104317-t30dg6oj 227 5 the the DT cord-104317-t30dg6oj 227 6 beneficial beneficial JJ cord-104317-t30dg6oj 227 7 properties property NNS cord-104317-t30dg6oj 227 8 of of IN cord-104317-t30dg6oj 227 9 EREs EREs NNP cord-104317-t30dg6oj 227 10 is be VBZ cord-104317-t30dg6oj 227 11 of of IN cord-104317-t30dg6oj 227 12 much much JJ cord-104317-t30dg6oj 227 13 scientific scientific JJ cord-104317-t30dg6oj 227 14 import import NN cord-104317-t30dg6oj 227 15 . . . cord-104317-t30dg6oj 228 1 For for IN cord-104317-t30dg6oj 228 2 years year NNS cord-104317-t30dg6oj 228 3 it -PRON- PRP cord-104317-t30dg6oj 228 4 has have VBZ cord-104317-t30dg6oj 228 5 been be VBN cord-104317-t30dg6oj 228 6 debated debate VBN cord-104317-t30dg6oj 228 7 whether whether IN cord-104317-t30dg6oj 228 8 gene gene NN cord-104317-t30dg6oj 228 9 therapy therapy NN cord-104317-t30dg6oj 228 10 using use VBG cord-104317-t30dg6oj 228 11 retroviral retroviral JJ cord-104317-t30dg6oj 228 12 vectors vector NNS cord-104317-t30dg6oj 228 13 for for IN cord-104317-t30dg6oj 228 14 insertion insertion NN cord-104317-t30dg6oj 228 15 of of IN cord-104317-t30dg6oj 228 16 genes gene NNS cord-104317-t30dg6oj 228 17 into into IN cord-104317-t30dg6oj 228 18 an an DT cord-104317-t30dg6oj 228 19 individual individual NN cord-104317-t30dg6oj 228 20 would would MD cord-104317-t30dg6oj 228 21 be be VB cord-104317-t30dg6oj 228 22 of of IN cord-104317-t30dg6oj 228 23 more more JJR cord-104317-t30dg6oj 228 24 help help NN cord-104317-t30dg6oj 228 25 than than IN cord-104317-t30dg6oj 228 26 harm harm NN cord-104317-t30dg6oj 228 27 . . . cord-104317-t30dg6oj 229 1 Overall overall RB cord-104317-t30dg6oj 229 2 the the DT cord-104317-t30dg6oj 229 3 utility utility NN cord-104317-t30dg6oj 229 4 of of IN cord-104317-t30dg6oj 229 5 such such JJ cord-104317-t30dg6oj 229 6 methods method NNS cord-104317-t30dg6oj 229 7 have have VBP cord-104317-t30dg6oj 229 8 been be VBN cord-104317-t30dg6oj 229 9 tempered temper VBN cord-104317-t30dg6oj 229 10 by by IN cord-104317-t30dg6oj 229 11 the the DT cord-104317-t30dg6oj 229 12 observed observed JJ cord-104317-t30dg6oj 229 13 oncogenic oncogenic JJ cord-104317-t30dg6oj 229 14 potential potential NN cord-104317-t30dg6oj 229 15 of of IN cord-104317-t30dg6oj 229 16 such such JJ cord-104317-t30dg6oj 229 17 therapies therapy NNS cord-104317-t30dg6oj 229 18 [ [ -LRB- cord-104317-t30dg6oj 229 19 134 134 CD cord-104317-t30dg6oj 229 20 ] ] -RRB- cord-104317-t30dg6oj 229 21 . . . cord-104317-t30dg6oj 230 1 Recently recently RB cord-104317-t30dg6oj 230 2 , , , cord-104317-t30dg6oj 230 3 studies study NNS cord-104317-t30dg6oj 230 4 with with IN cord-104317-t30dg6oj 230 5 retroviral retroviral NN cord-104317-t30dg6oj 230 6 - - HYPH cord-104317-t30dg6oj 230 7 modified modify VBN cord-104317-t30dg6oj 230 8 Chimeric Chimeric NNP cord-104317-t30dg6oj 230 9 Antigen Antigen NNP cord-104317-t30dg6oj 230 10 Receptor Receptor NNP cord-104317-t30dg6oj 230 11 T T NNP cord-104317-t30dg6oj 230 12 - - HYPH cord-104317-t30dg6oj 230 13 cells cell NNS cord-104317-t30dg6oj 230 14 ( ( -LRB- cord-104317-t30dg6oj 230 15 CAR CAR NNP cord-104317-t30dg6oj 230 16 Tcells Tcells NNP cord-104317-t30dg6oj 230 17 ) ) -RRB- cord-104317-t30dg6oj 230 18 have have VBP cord-104317-t30dg6oj 230 19 shown show VBN cord-104317-t30dg6oj 230 20 impressive impressive JJ cord-104317-t30dg6oj 230 21 application application NN cord-104317-t30dg6oj 230 22 for for IN cord-104317-t30dg6oj 230 23 the the DT cord-104317-t30dg6oj 230 24 activation activation NN cord-104317-t30dg6oj 230 25 of of IN cord-104317-t30dg6oj 230 26 adaptive adaptive JJ cord-104317-t30dg6oj 230 27 immunity immunity NN cord-104317-t30dg6oj 230 28 against against IN cord-104317-t30dg6oj 230 29 cancers cancer NNS cord-104317-t30dg6oj 230 30 , , , cord-104317-t30dg6oj 230 31 though though IN cord-104317-t30dg6oj 230 32 there there EX cord-104317-t30dg6oj 230 33 have have VBP cord-104317-t30dg6oj 230 34 also also RB cord-104317-t30dg6oj 230 35 been be VBN cord-104317-t30dg6oj 230 36 morbid morbid JJ cord-104317-t30dg6oj 230 37 failures failure NNS cord-104317-t30dg6oj 230 38 in in IN cord-104317-t30dg6oj 230 39 this this DT cord-104317-t30dg6oj 230 40 field field NN cord-104317-t30dg6oj 230 41 [ [ -LRB- cord-104317-t30dg6oj 230 42 135 135 CD cord-104317-t30dg6oj 230 43 ] ] -RRB- cord-104317-t30dg6oj 230 44 . . . cord-104317-t30dg6oj 231 1 The the DT cord-104317-t30dg6oj 231 2 application application NN cord-104317-t30dg6oj 231 3 of of IN cord-104317-t30dg6oj 231 4 retroviral retroviral NN cord-104317-t30dg6oj 231 5 - - HYPH cord-104317-t30dg6oj 231 6 modified modify VBN cord-104317-t30dg6oj 231 7 CAR car NN cord-104317-t30dg6oj 231 8 T T NNP cord-104317-t30dg6oj 231 9 - - HYPH cord-104317-t30dg6oj 231 10 cells cell NNS cord-104317-t30dg6oj 231 11 could could MD cord-104317-t30dg6oj 231 12 presumably presumably RB cord-104317-t30dg6oj 231 13 be be VB cord-104317-t30dg6oj 231 14 expanded expand VBN cord-104317-t30dg6oj 231 15 to to IN cord-104317-t30dg6oj 231 16 infectious infectious JJ cord-104317-t30dg6oj 231 17 disease disease NN cord-104317-t30dg6oj 231 18 as as RB cord-104317-t30dg6oj 231 19 well well RB cord-104317-t30dg6oj 231 20 . . . cord-104317-t30dg6oj 232 1 These these DT cord-104317-t30dg6oj 232 2 progressive progressive JJ cord-104317-t30dg6oj 232 3 areas area NNS cord-104317-t30dg6oj 232 4 of of IN cord-104317-t30dg6oj 232 5 medical medical JJ cord-104317-t30dg6oj 232 6 science science NN cord-104317-t30dg6oj 232 7 will will MD cord-104317-t30dg6oj 232 8 continue continue VB cord-104317-t30dg6oj 232 9 to to TO cord-104317-t30dg6oj 232 10 be be VB cord-104317-t30dg6oj 232 11 explored explore VBN cord-104317-t30dg6oj 232 12 and and CC cord-104317-t30dg6oj 232 13 debated debate VBN cord-104317-t30dg6oj 232 14 well well RB cord-104317-t30dg6oj 232 15 into into IN cord-104317-t30dg6oj 232 16 the the DT cord-104317-t30dg6oj 232 17 future future NN cord-104317-t30dg6oj 232 18 , , , cord-104317-t30dg6oj 232 19 and and CC cord-104317-t30dg6oj 232 20 better well JJR cord-104317-t30dg6oj 232 21 understanding understand VBG cord-104317-t30dg6oj 232 22 the the DT cord-104317-t30dg6oj 232 23 relationship relationship NN cord-104317-t30dg6oj 232 24 of of IN cord-104317-t30dg6oj 232 25 EREs ere NNS cord-104317-t30dg6oj 232 26 with with IN cord-104317-t30dg6oj 232 27 their -PRON- PRP$ cord-104317-t30dg6oj 232 28 human human JJ cord-104317-t30dg6oj 232 29 hosts host NNS cord-104317-t30dg6oj 232 30 will will MD cord-104317-t30dg6oj 232 31 be be VB cord-104317-t30dg6oj 232 32 indispensable indispensable JJ cord-104317-t30dg6oj 232 33 for for IN cord-104317-t30dg6oj 232 34 these these DT cord-104317-t30dg6oj 232 35 studies study NNS cord-104317-t30dg6oj 232 36 . . . cord-104317-t30dg6oj 233 1 Similar similar JJ cord-104317-t30dg6oj 233 2 to to IN cord-104317-t30dg6oj 233 3 the the DT cord-104317-t30dg6oj 233 4 primary primary JJ cord-104317-t30dg6oj 233 5 symbionts symbiont NNS cord-104317-t30dg6oj 233 6 , , , cord-104317-t30dg6oj 233 7 secondary secondary JJ cord-104317-t30dg6oj 233 8 symbionts symbiont NNS cord-104317-t30dg6oj 233 9 form form VBP cord-104317-t30dg6oj 233 10 mutualistic mutualistic JJ cord-104317-t30dg6oj 233 11 relationships relationship NNS cord-104317-t30dg6oj 233 12 with with IN cord-104317-t30dg6oj 233 13 their -PRON- PRP$ cord-104317-t30dg6oj 233 14 host host NN cord-104317-t30dg6oj 233 15 , , , cord-104317-t30dg6oj 233 16 but but CC cord-104317-t30dg6oj 233 17 are be VBP cord-104317-t30dg6oj 233 18 instead instead RB cord-104317-t30dg6oj 233 19 acquired acquire VBN cord-104317-t30dg6oj 233 20 via via IN cord-104317-t30dg6oj 233 21 non non JJ cord-104317-t30dg6oj 233 22 - - JJ cord-104317-t30dg6oj 233 23 germline germline JJ cord-104317-t30dg6oj 233 24 vertical vertical JJ cord-104317-t30dg6oj 233 25 transmission transmission NN cord-104317-t30dg6oj 233 26 or or CC cord-104317-t30dg6oj 233 27 horizontally horizontally RB cord-104317-t30dg6oj 233 28 during during IN cord-104317-t30dg6oj 233 29 the the DT cord-104317-t30dg6oj 233 30 post post JJ cord-104317-t30dg6oj 233 31 - - JJ cord-104317-t30dg6oj 233 32 natal natal JJ cord-104317-t30dg6oj 233 33 life life NN cord-104317-t30dg6oj 233 34 of of IN cord-104317-t30dg6oj 233 35 the the DT cord-104317-t30dg6oj 233 36 host host NN cord-104317-t30dg6oj 233 37 . . . cord-104317-t30dg6oj 234 1 A a DT cord-104317-t30dg6oj 234 2 popular popular JJ cord-104317-t30dg6oj 234 3 example example NN cord-104317-t30dg6oj 234 4 is be VBZ cord-104317-t30dg6oj 234 5 that that DT cord-104317-t30dg6oj 234 6 of of IN cord-104317-t30dg6oj 234 7 phages phage NNS cord-104317-t30dg6oj 234 8 . . . cord-104317-t30dg6oj 235 1 Beginning begin VBG cord-104317-t30dg6oj 235 2 with with IN cord-104317-t30dg6oj 235 3 the the DT cord-104317-t30dg6oj 235 4 microbial microbial JJ cord-104317-t30dg6oj 235 5 colonization colonization NN cord-104317-t30dg6oj 235 6 of of IN cord-104317-t30dg6oj 235 7 a a DT cord-104317-t30dg6oj 235 8 child child NN cord-104317-t30dg6oj 235 9 during during IN cord-104317-t30dg6oj 235 10 birth birth NN cord-104317-t30dg6oj 235 11 , , , cord-104317-t30dg6oj 235 12 phages phage NNS cord-104317-t30dg6oj 235 13 hitch hitch VBP cord-104317-t30dg6oj 235 14 a a DT cord-104317-t30dg6oj 235 15 ride ride NN cord-104317-t30dg6oj 235 16 with with IN cord-104317-t30dg6oj 235 17 their -PRON- PRP$ cord-104317-t30dg6oj 235 18 host host NN cord-104317-t30dg6oj 235 19 bacteria bacteria NNS cord-104317-t30dg6oj 235 20 . . . cord-104317-t30dg6oj 236 1 Phages phage NNS cord-104317-t30dg6oj 236 2 can can MD cord-104317-t30dg6oj 236 3 regulate regulate VB cord-104317-t30dg6oj 236 4 bacterial bacterial JJ cord-104317-t30dg6oj 236 5 species specie NNS cord-104317-t30dg6oj 236 6 in in IN cord-104317-t30dg6oj 236 7 the the DT cord-104317-t30dg6oj 236 8 gut gut NN cord-104317-t30dg6oj 236 9 , , , cord-104317-t30dg6oj 236 10 as as IN cord-104317-t30dg6oj 236 11 it -PRON- PRP cord-104317-t30dg6oj 236 12 is be VBZ cord-104317-t30dg6oj 236 13 known know VBN cord-104317-t30dg6oj 236 14 that that IN cord-104317-t30dg6oj 236 15 phages phage NNS cord-104317-t30dg6oj 236 16 can can MD cord-104317-t30dg6oj 236 17 be be VB cord-104317-t30dg6oj 236 18 coopted coopte VBN cord-104317-t30dg6oj 236 19 into into IN cord-104317-t30dg6oj 236 20 mucosal mucosal JJ cord-104317-t30dg6oj 236 21 surfaces surface NNS cord-104317-t30dg6oj 236 22 for for IN cord-104317-t30dg6oj 236 23 this this DT cord-104317-t30dg6oj 236 24 purpose purpose NN cord-104317-t30dg6oj 236 25 [ [ -LRB- cord-104317-t30dg6oj 236 26 136 136 CD cord-104317-t30dg6oj 236 27 ] ] -RRB- cord-104317-t30dg6oj 236 28 . . . cord-104317-t30dg6oj 237 1 Free free JJ cord-104317-t30dg6oj 237 2 phages phage NNS cord-104317-t30dg6oj 237 3 may may MD cord-104317-t30dg6oj 237 4 also also RB cord-104317-t30dg6oj 237 5 serve serve VB cord-104317-t30dg6oj 237 6 a a DT cord-104317-t30dg6oj 237 7 similar similar JJ cord-104317-t30dg6oj 237 8 role role NN cord-104317-t30dg6oj 237 9 as as IN cord-104317-t30dg6oj 237 10 sentinels sentinel NNS cord-104317-t30dg6oj 237 11 maintaining maintain VBG cord-104317-t30dg6oj 237 12 a a DT cord-104317-t30dg6oj 237 13 balanced balanced JJ cord-104317-t30dg6oj 237 14 microbiota microbiota NN cord-104317-t30dg6oj 237 15 . . . cord-104317-t30dg6oj 238 1 These these DT cord-104317-t30dg6oj 238 2 benefits benefit NNS cord-104317-t30dg6oj 238 3 have have VBP cord-104317-t30dg6oj 238 4 been be VBN cord-104317-t30dg6oj 238 5 studied study VBN cord-104317-t30dg6oj 238 6 extensively extensively RB cord-104317-t30dg6oj 238 7 as as IN cord-104317-t30dg6oj 238 8 possible possible JJ cord-104317-t30dg6oj 238 9 medical medical JJ cord-104317-t30dg6oj 238 10 tools tool NNS cord-104317-t30dg6oj 238 11 in in IN cord-104317-t30dg6oj 238 12 phage phage NN cord-104317-t30dg6oj 238 13 therapy therapy NN cord-104317-t30dg6oj 238 14 ( ( -LRB- cord-104317-t30dg6oj 238 15 reviewed review VBN cord-104317-t30dg6oj 238 16 in in IN cord-104317-t30dg6oj 238 17 [ [ -LRB- cord-104317-t30dg6oj 238 18 137 137 CD cord-104317-t30dg6oj 238 19 , , , cord-104317-t30dg6oj 238 20 138 138 CD cord-104317-t30dg6oj 238 21 ] ] -RRB- cord-104317-t30dg6oj 238 22 ) ) -RRB- cord-104317-t30dg6oj 238 23 and and CC cord-104317-t30dg6oj 238 24 there there EX cord-104317-t30dg6oj 238 25 has have VBZ cord-104317-t30dg6oj 238 26 recently recently RB cord-104317-t30dg6oj 238 27 been be VBN cord-104317-t30dg6oj 238 28 a a DT cord-104317-t30dg6oj 238 29 resurgence resurgence NN cord-104317-t30dg6oj 238 30 of of IN cord-104317-t30dg6oj 238 31 interest interest NN cord-104317-t30dg6oj 238 32 as as IN cord-104317-t30dg6oj 238 33 the the DT cord-104317-t30dg6oj 238 34 problem problem NN cord-104317-t30dg6oj 238 35 of of IN cord-104317-t30dg6oj 238 36 antimicrobial antimicrobial JJ cord-104317-t30dg6oj 238 37 resistance resistance NN cord-104317-t30dg6oj 238 38 has have VBZ cord-104317-t30dg6oj 238 39 become become VBN cord-104317-t30dg6oj 238 40 more more RBR cord-104317-t30dg6oj 238 41 dire dire JJ cord-104317-t30dg6oj 238 42 [ [ -LRB- cord-104317-t30dg6oj 238 43 139 139 CD cord-104317-t30dg6oj 238 44 ] ] -RRB- cord-104317-t30dg6oj 238 45 . . . cord-104317-t30dg6oj 239 1 These these DT cord-104317-t30dg6oj 239 2 same same JJ cord-104317-t30dg6oj 239 3 principles principle NNS cord-104317-t30dg6oj 239 4 can can MD cord-104317-t30dg6oj 239 5 likely likely RB cord-104317-t30dg6oj 239 6 be be VB cord-104317-t30dg6oj 239 7 extended extend VBN cord-104317-t30dg6oj 239 8 to to IN cord-104317-t30dg6oj 239 9 viruses virus NNS cord-104317-t30dg6oj 239 10 that that WDT cord-104317-t30dg6oj 239 11 parasitize parasitize VBP cord-104317-t30dg6oj 239 12 other other JJ cord-104317-t30dg6oj 239 13 microbes microbe NNS cord-104317-t30dg6oj 239 14 and and CC cord-104317-t30dg6oj 239 15 macrobes macrobe NNS cord-104317-t30dg6oj 239 16 as as RB cord-104317-t30dg6oj 239 17 well well RB cord-104317-t30dg6oj 239 18 . . . cord-104317-t30dg6oj 240 1 Other other JJ cord-104317-t30dg6oj 240 2 examples example NNS cord-104317-t30dg6oj 240 3 of of IN cord-104317-t30dg6oj 240 4 secondary secondary JJ cord-104317-t30dg6oj 240 5 symbiotic symbiotic JJ cord-104317-t30dg6oj 240 6 viruses virus NNS cord-104317-t30dg6oj 240 7 are be VBP cord-104317-t30dg6oj 240 8 isolated isolate VBN cord-104317-t30dg6oj 240 9 , , , cord-104317-t30dg6oj 240 10 but but CC cord-104317-t30dg6oj 240 11 numerous numerous JJ cord-104317-t30dg6oj 240 12 . . . cord-104317-t30dg6oj 241 1 In in IN cord-104317-t30dg6oj 241 2 general general JJ cord-104317-t30dg6oj 241 3 , , , cord-104317-t30dg6oj 241 4 these these DT cord-104317-t30dg6oj 241 5 viruses virus NNS cord-104317-t30dg6oj 241 6 likely likely RB cord-104317-t30dg6oj 241 7 compete compete VBP cord-104317-t30dg6oj 241 8 for for IN cord-104317-t30dg6oj 241 9 receptors receptor NNS cord-104317-t30dg6oj 241 10 , , , cord-104317-t30dg6oj 241 11 cellular cellular JJ cord-104317-t30dg6oj 241 12 resources resource NNS cord-104317-t30dg6oj 241 13 , , , cord-104317-t30dg6oj 241 14 or or CC cord-104317-t30dg6oj 241 15 niches niche NNS cord-104317-t30dg6oj 241 16 within within IN cord-104317-t30dg6oj 241 17 hosts host NNS cord-104317-t30dg6oj 241 18 to to TO cord-104317-t30dg6oj 241 19 confer confer VB cord-104317-t30dg6oj 241 20 protection protection NN cord-104317-t30dg6oj 241 21 . . . cord-104317-t30dg6oj 242 1 Hepatitis hepatitis NN cord-104317-t30dg6oj 242 2 G G NNP cord-104317-t30dg6oj 242 3 Virus virus NN cord-104317-t30dg6oj 242 4 ( ( -LRB- cord-104317-t30dg6oj 242 5 HGV HGV NNP cord-104317-t30dg6oj 242 6 ) ) -RRB- cord-104317-t30dg6oj 242 7 is be VBZ cord-104317-t30dg6oj 242 8 known know VBN cord-104317-t30dg6oj 242 9 to to TO cord-104317-t30dg6oj 242 10 slow slow VB cord-104317-t30dg6oj 242 11 development development NN cord-104317-t30dg6oj 242 12 of of IN cord-104317-t30dg6oj 242 13 HIV HIV NNP cord-104317-t30dg6oj 242 14 infection infection NN cord-104317-t30dg6oj 242 15 to to IN cord-104317-t30dg6oj 242 16 AIDS AIDS NNP cord-104317-t30dg6oj 242 17 pathogenesis pathogenesis NN cord-104317-t30dg6oj 242 18 [ [ -LRB- cord-104317-t30dg6oj 242 19 140 140 CD cord-104317-t30dg6oj 242 20 , , , cord-104317-t30dg6oj 242 21 141 141 CD cord-104317-t30dg6oj 242 22 ] ] -RRB- cord-104317-t30dg6oj 242 23 and and CC cord-104317-t30dg6oj 242 24 Human Human NNP cord-104317-t30dg6oj 242 25 Cytomegalovirus Cytomegalovirus NNP cord-104317-t30dg6oj 242 26 ( ( -LRB- cord-104317-t30dg6oj 242 27 HCMV HCMV NNP cord-104317-t30dg6oj 242 28 ) ) -RRB- cord-104317-t30dg6oj 242 29 infection infection NN cord-104317-t30dg6oj 242 30 can can MD cord-104317-t30dg6oj 242 31 suppress suppress VB cord-104317-t30dg6oj 242 32 HIV HIV NNP cord-104317-t30dg6oj 242 33 infection infection NN cord-104317-t30dg6oj 242 34 by by IN cord-104317-t30dg6oj 242 35 limiting limit VBG cord-104317-t30dg6oj 242 36 availability availability NN cord-104317-t30dg6oj 242 37 of of IN cord-104317-t30dg6oj 242 38 the the DT cord-104317-t30dg6oj 242 39 coreceptor coreceptor NN cord-104317-t30dg6oj 242 40 CCR5 CCR5 NNP cord-104317-t30dg6oj 242 41 on on IN cord-104317-t30dg6oj 242 42 macrophages macrophage NNS cord-104317-t30dg6oj 242 43 [ [ -LRB- cord-104317-t30dg6oj 242 44 142 142 CD cord-104317-t30dg6oj 242 45 ] ] -RRB- cord-104317-t30dg6oj 242 46 . . . cord-104317-t30dg6oj 243 1 Infection infection NN cord-104317-t30dg6oj 243 2 with with IN cord-104317-t30dg6oj 243 3 Hepatitis Hepatitis NNP cord-104317-t30dg6oj 243 4 A A NNP cord-104317-t30dg6oj 243 5 Virus virus NN cord-104317-t30dg6oj 243 6 ( ( -LRB- cord-104317-t30dg6oj 243 7 HAV hav VB cord-104317-t30dg6oj 243 8 ) ) -RRB- cord-104317-t30dg6oj 243 9 can can MD cord-104317-t30dg6oj 243 10 suppress suppress VB cord-104317-t30dg6oj 243 11 infection infection NN cord-104317-t30dg6oj 243 12 with with IN cord-104317-t30dg6oj 243 13 HCV HCV NNP cord-104317-t30dg6oj 243 14 and and CC cord-104317-t30dg6oj 243 15 may may MD cord-104317-t30dg6oj 243 16 actually actually RB cord-104317-t30dg6oj 243 17 promote promote VB cord-104317-t30dg6oj 243 18 clearance clearance NN cord-104317-t30dg6oj 243 19 [ [ -LRB- cord-104317-t30dg6oj 243 20 143 143 CD cord-104317-t30dg6oj 243 21 ] ] -RRB- cord-104317-t30dg6oj 243 22 . . . cord-104317-t30dg6oj 244 1 Evidence evidence NN cord-104317-t30dg6oj 244 2 from from IN cord-104317-t30dg6oj 244 3 mice mouse NNS cord-104317-t30dg6oj 244 4 supports support VBZ cord-104317-t30dg6oj 244 5 the the DT cord-104317-t30dg6oj 244 6 assertion assertion NN cord-104317-t30dg6oj 244 7 that that IN cord-104317-t30dg6oj 244 8 viruses virus NNS cord-104317-t30dg6oj 244 9 can can MD cord-104317-t30dg6oj 244 10 confer confer VB cord-104317-t30dg6oj 244 11 resistance resistance NN cord-104317-t30dg6oj 244 12 to to IN cord-104317-t30dg6oj 244 13 non non JJ cord-104317-t30dg6oj 244 14 - - JJ cord-104317-t30dg6oj 244 15 viral viral JJ cord-104317-t30dg6oj 244 16 disease disease NN cord-104317-t30dg6oj 244 17 as as RB cord-104317-t30dg6oj 244 18 well well RB cord-104317-t30dg6oj 244 19 , , , cord-104317-t30dg6oj 244 20 as as IN cord-104317-t30dg6oj 244 21 infection infection NN cord-104317-t30dg6oj 244 22 with with IN cord-104317-t30dg6oj 244 23 murine murine JJ cord-104317-t30dg6oj 244 24 gammaherpesvirus gammaherpesvirus JJ cord-104317-t30dg6oj 244 25 results result NNS cord-104317-t30dg6oj 244 26 in in IN cord-104317-t30dg6oj 244 27 protection protection NN cord-104317-t30dg6oj 244 28 from from IN cord-104317-t30dg6oj 244 29 challenge challenge NN cord-104317-t30dg6oj 244 30 with with IN cord-104317-t30dg6oj 244 31 Listeria Listeria NNP cord-104317-t30dg6oj 244 32 [ [ -LRB- cord-104317-t30dg6oj 244 33 144 144 CD cord-104317-t30dg6oj 244 34 ] ] -RRB- cord-104317-t30dg6oj 244 35 and and CC cord-104317-t30dg6oj 244 36 Type type NN cord-104317-t30dg6oj 244 37 1 1 CD cord-104317-t30dg6oj 244 38 Diabetes diabetes NN cord-104317-t30dg6oj 244 39 can can MD cord-104317-t30dg6oj 244 40 be be VB cord-104317-t30dg6oj 244 41 prevented prevent VBN cord-104317-t30dg6oj 244 42 in in IN cord-104317-t30dg6oj 244 43 mice mouse NNS cord-104317-t30dg6oj 244 44 infected infect VBN cord-104317-t30dg6oj 244 45 with with IN cord-104317-t30dg6oj 244 46 lymphotropic lymphotropic JJ cord-104317-t30dg6oj 244 47 viruses virus NNS cord-104317-t30dg6oj 244 48 [ [ -LRB- cord-104317-t30dg6oj 244 49 145 145 CD cord-104317-t30dg6oj 244 50 ] ] -RRB- cord-104317-t30dg6oj 244 51 . . . cord-104317-t30dg6oj 245 1 Oncolytic oncolytic JJ cord-104317-t30dg6oj 245 2 viruses virus NNS cord-104317-t30dg6oj 245 3 , , , cord-104317-t30dg6oj 245 4 which which WDT cord-104317-t30dg6oj 245 5 specifically specifically RB cord-104317-t30dg6oj 245 6 target target VBP cord-104317-t30dg6oj 245 7 , , , cord-104317-t30dg6oj 245 8 infect infect VBP cord-104317-t30dg6oj 245 9 , , , cord-104317-t30dg6oj 245 10 and and CC cord-104317-t30dg6oj 245 11 kill kill VB cord-104317-t30dg6oj 245 12 tumor tumor NN cord-104317-t30dg6oj 245 13 cells cell NNS cord-104317-t30dg6oj 245 14 are be VBP cord-104317-t30dg6oj 245 15 also also RB cord-104317-t30dg6oj 245 16 notable notable JJ cord-104317-t30dg6oj 245 17 in in IN cord-104317-t30dg6oj 245 18 both both DT cord-104317-t30dg6oj 245 19 their -PRON- PRP$ cord-104317-t30dg6oj 245 20 novelty novelty NN cord-104317-t30dg6oj 245 21 and and CC cord-104317-t30dg6oj 245 22 their -PRON- PRP$ cord-104317-t30dg6oj 245 23 clinical clinical JJ cord-104317-t30dg6oj 245 24 utility utility NN cord-104317-t30dg6oj 245 25 ( ( -LRB- cord-104317-t30dg6oj 245 26 reviewed review VBN cord-104317-t30dg6oj 245 27 in in IN cord-104317-t30dg6oj 245 28 [ [ -LRB- cord-104317-t30dg6oj 245 29 146 146 CD cord-104317-t30dg6oj 245 30 ] ] -RRB- cord-104317-t30dg6oj 245 31 [ [ -LRB- cord-104317-t30dg6oj 245 32 147 147 CD cord-104317-t30dg6oj 245 33 ] ] -RRB- cord-104317-t30dg6oj 245 34 [ [ -LRB- cord-104317-t30dg6oj 245 35 148 148 CD cord-104317-t30dg6oj 245 36 ] ] -RRB- cord-104317-t30dg6oj 245 37 ) ) -RRB- cord-104317-t30dg6oj 245 38 . . . cord-104317-t30dg6oj 246 1 Viruses virus NNS cord-104317-t30dg6oj 246 2 may may MD cord-104317-t30dg6oj 246 3 even even RB cord-104317-t30dg6oj 246 4 be be VB cord-104317-t30dg6oj 246 5 able able JJ cord-104317-t30dg6oj 246 6 to to TO cord-104317-t30dg6oj 246 7 provide provide VB cord-104317-t30dg6oj 246 8 developmental developmental JJ cord-104317-t30dg6oj 246 9 and and CC cord-104317-t30dg6oj 246 10 immunological immunological JJ cord-104317-t30dg6oj 246 11 benefits benefit NNS cord-104317-t30dg6oj 246 12 not not RB cord-104317-t30dg6oj 246 13 unlike unlike IN cord-104317-t30dg6oj 246 14 that that DT cord-104317-t30dg6oj 246 15 of of IN cord-104317-t30dg6oj 246 16 the the DT cord-104317-t30dg6oj 246 17 bacterial bacterial JJ cord-104317-t30dg6oj 246 18 microbiota microbiota NN cord-104317-t30dg6oj 246 19 , , , cord-104317-t30dg6oj 246 20 as as IN cord-104317-t30dg6oj 246 21 evidenced evidence VBN cord-104317-t30dg6oj 246 22 by by IN cord-104317-t30dg6oj 246 23 the the DT cord-104317-t30dg6oj 246 24 establishment establishment NN cord-104317-t30dg6oj 246 25 of of IN cord-104317-t30dg6oj 246 26 gut gut NN cord-104317-t30dg6oj 246 27 homeostasis homeostasis NN cord-104317-t30dg6oj 246 28 in in IN cord-104317-t30dg6oj 246 29 mice mouse NNS cord-104317-t30dg6oj 246 30 colonized colonize VBN cord-104317-t30dg6oj 246 31 with with IN cord-104317-t30dg6oj 246 32 norovirus norovirus NN cord-104317-t30dg6oj 246 33 [ [ -LRB- cord-104317-t30dg6oj 246 34 149 149 CD cord-104317-t30dg6oj 246 35 ] ] -RRB- cord-104317-t30dg6oj 246 36 . . . cord-104317-t30dg6oj 247 1 Endogenous endogenous JJ cord-104317-t30dg6oj 247 2 retroelements retroelement NNS cord-104317-t30dg6oj 247 3 could could MD cord-104317-t30dg6oj 247 4 also also RB cord-104317-t30dg6oj 247 5 presumably presumably RB cord-104317-t30dg6oj 247 6 be be VB cord-104317-t30dg6oj 247 7 included include VBN cord-104317-t30dg6oj 247 8 here here RB cord-104317-t30dg6oj 247 9 in in IN cord-104317-t30dg6oj 247 10 the the DT cord-104317-t30dg6oj 247 11 case case NN cord-104317-t30dg6oj 247 12 of of IN cord-104317-t30dg6oj 247 13 their -PRON- PRP$ cord-104317-t30dg6oj 247 14 population population NN cord-104317-t30dg6oj 247 15 of of IN cord-104317-t30dg6oj 247 16 a a DT cord-104317-t30dg6oj 247 17 nongermline nongermline NN cord-104317-t30dg6oj 247 18 subset subset VBN cord-104317-t30dg6oj 247 19 of of IN cord-104317-t30dg6oj 247 20 cells cell NNS cord-104317-t30dg6oj 247 21 within within IN cord-104317-t30dg6oj 247 22 an an DT cord-104317-t30dg6oj 247 23 individual individual NN cord-104317-t30dg6oj 247 24 and and CC cord-104317-t30dg6oj 247 25 conferral conferral JJ cord-104317-t30dg6oj 247 26 of of IN cord-104317-t30dg6oj 247 27 benefit benefit NN cord-104317-t30dg6oj 247 28 to to IN cord-104317-t30dg6oj 247 29 the the DT cord-104317-t30dg6oj 247 30 host host NN cord-104317-t30dg6oj 247 31 . . . cord-104317-t30dg6oj 248 1 One one CD cord-104317-t30dg6oj 248 2 of of IN cord-104317-t30dg6oj 248 3 the the DT cord-104317-t30dg6oj 248 4 main main JJ cord-104317-t30dg6oj 248 5 functions function NNS cord-104317-t30dg6oj 248 6 of of IN cord-104317-t30dg6oj 248 7 secondary secondary JJ cord-104317-t30dg6oj 248 8 symbionts symbiont NNS cord-104317-t30dg6oj 248 9 may may MD cord-104317-t30dg6oj 248 10 be be VB cord-104317-t30dg6oj 248 11 to to TO cord-104317-t30dg6oj 248 12 help help VB cord-104317-t30dg6oj 248 13 maintain maintain VB cord-104317-t30dg6oj 248 14 a a DT cord-104317-t30dg6oj 248 15 baseline baseline NN cord-104317-t30dg6oj 248 16 of of IN cord-104317-t30dg6oj 248 17 immune immune JJ cord-104317-t30dg6oj 248 18 activation activation NN cord-104317-t30dg6oj 248 19 in in IN cord-104317-t30dg6oj 248 20 order order NN cord-104317-t30dg6oj 248 21 to to TO cord-104317-t30dg6oj 248 22 give give VB cord-104317-t30dg6oj 248 23 the the DT cord-104317-t30dg6oj 248 24 host host NN cord-104317-t30dg6oj 248 25 a a DT cord-104317-t30dg6oj 248 26 head head NN cord-104317-t30dg6oj 248 27 start start VB cord-104317-t30dg6oj 248 28 upon upon IN cord-104317-t30dg6oj 248 29 challenge challenge NN cord-104317-t30dg6oj 248 30 with with IN cord-104317-t30dg6oj 248 31 incoming incoming JJ cord-104317-t30dg6oj 248 32 pathogens pathogen NNS cord-104317-t30dg6oj 248 33 . . . cord-104317-t30dg6oj 249 1 It -PRON- PRP cord-104317-t30dg6oj 249 2 has have VBZ cord-104317-t30dg6oj 249 3 been be VBN cord-104317-t30dg6oj 249 4 estimated estimate VBN cord-104317-t30dg6oj 249 5 that that IN cord-104317-t30dg6oj 249 6 healthy healthy JJ cord-104317-t30dg6oj 249 7 humans human NNS cord-104317-t30dg6oj 249 8 are be VBP cord-104317-t30dg6oj 249 9 infected infect VBN cord-104317-t30dg6oj 249 10 with with IN cord-104317-t30dg6oj 249 11 > > XX cord-104317-t30dg6oj 249 12 10 10 CD cord-104317-t30dg6oj 249 13 viral viral JJ cord-104317-t30dg6oj 249 14 infections infection NNS cord-104317-t30dg6oj 249 15 at at IN cord-104317-t30dg6oj 249 16 any any DT cord-104317-t30dg6oj 249 17 given give VBN cord-104317-t30dg6oj 249 18 time time NN cord-104317-t30dg6oj 249 19 [ [ -LRB- cord-104317-t30dg6oj 249 20 51 51 CD cord-104317-t30dg6oj 249 21 ] ] -RRB- cord-104317-t30dg6oj 249 22 . . . cord-104317-t30dg6oj 250 1 This this DT cord-104317-t30dg6oj 250 2 constant constant JJ cord-104317-t30dg6oj 250 3 barrage barrage NN cord-104317-t30dg6oj 250 4 of of IN cord-104317-t30dg6oj 250 5 immunogenic immunogenic JJ cord-104317-t30dg6oj 250 6 material material NN cord-104317-t30dg6oj 250 7 presumably presumably RB cord-104317-t30dg6oj 250 8 drives drive VBZ cord-104317-t30dg6oj 250 9 a a DT cord-104317-t30dg6oj 250 10 smoldering smolder VBG cord-104317-t30dg6oj 250 11 activation activation NN cord-104317-t30dg6oj 250 12 of of IN cord-104317-t30dg6oj 250 13 both both DT cord-104317-t30dg6oj 250 14 innate innate JJ cord-104317-t30dg6oj 250 15 and and CC cord-104317-t30dg6oj 250 16 adaptive adaptive JJ cord-104317-t30dg6oj 250 17 immunity immunity NN cord-104317-t30dg6oj 250 18 . . . cord-104317-t30dg6oj 251 1 From from IN cord-104317-t30dg6oj 251 2 this this DT cord-104317-t30dg6oj 251 3 , , , cord-104317-t30dg6oj 251 4 it -PRON- PRP cord-104317-t30dg6oj 251 5 may may MD cord-104317-t30dg6oj 251 6 be be VB cord-104317-t30dg6oj 251 7 concluded conclude VBN cord-104317-t30dg6oj 251 8 that that IN cord-104317-t30dg6oj 251 9 a a DT cord-104317-t30dg6oj 251 10 state state NN cord-104317-t30dg6oj 251 11 of of IN cord-104317-t30dg6oj 251 12 continual continual JJ cord-104317-t30dg6oj 251 13 challenge challenge NN cord-104317-t30dg6oj 251 14 may may MD cord-104317-t30dg6oj 251 15 be be VB cord-104317-t30dg6oj 251 16 integral integral JJ cord-104317-t30dg6oj 251 17 for for IN cord-104317-t30dg6oj 251 18 the the DT cord-104317-t30dg6oj 251 19 immune immune JJ cord-104317-t30dg6oj 251 20 system system NN cord-104317-t30dg6oj 251 21 to to TO cord-104317-t30dg6oj 251 22 be be VB cord-104317-t30dg6oj 251 23 fortified fortify VBN cord-104317-t30dg6oj 251 24 against against IN cord-104317-t30dg6oj 251 25 incoming incoming JJ cord-104317-t30dg6oj 251 26 pathogens pathogen NNS cord-104317-t30dg6oj 251 27 . . . cord-104317-t30dg6oj 252 1 While while IN cord-104317-t30dg6oj 252 2 there there EX cord-104317-t30dg6oj 252 3 is be VBZ cord-104317-t30dg6oj 252 4 a a DT cord-104317-t30dg6oj 252 5 plethora plethora NN cord-104317-t30dg6oj 252 6 of of IN cord-104317-t30dg6oj 252 7 research research NN cord-104317-t30dg6oj 252 8 about about IN cord-104317-t30dg6oj 252 9 secondary secondary JJ cord-104317-t30dg6oj 252 10 symbiotic symbiotic JJ cord-104317-t30dg6oj 252 11 bacteria bacteria NNS cord-104317-t30dg6oj 252 12 , , , cord-104317-t30dg6oj 252 13 similar similar JJ cord-104317-t30dg6oj 252 14 attention attention NN cord-104317-t30dg6oj 252 15 must must MD cord-104317-t30dg6oj 252 16 to to TO cord-104317-t30dg6oj 252 17 be be VB cord-104317-t30dg6oj 252 18 paid pay VBN cord-104317-t30dg6oj 252 19 to to IN cord-104317-t30dg6oj 252 20 the the DT cord-104317-t30dg6oj 252 21 virome virome NN cord-104317-t30dg6oj 252 22 . . . cord-104317-t30dg6oj 253 1 The the DT cord-104317-t30dg6oj 253 2 examples example NNS cord-104317-t30dg6oj 253 3 outlined outline VBN cord-104317-t30dg6oj 253 4 above above IN cord-104317-t30dg6oj 253 5 point point NN cord-104317-t30dg6oj 253 6 to to IN cord-104317-t30dg6oj 253 7 incredible incredible JJ cord-104317-t30dg6oj 253 8 benefit benefit NN cord-104317-t30dg6oj 253 9 derived derive VBN cord-104317-t30dg6oj 253 10 from from IN cord-104317-t30dg6oj 253 11 the the DT cord-104317-t30dg6oj 253 12 interaction interaction NN cord-104317-t30dg6oj 253 13 of of IN cord-104317-t30dg6oj 253 14 humans human NNS cord-104317-t30dg6oj 253 15 with with IN cord-104317-t30dg6oj 253 16 these these DT cord-104317-t30dg6oj 253 17 mutualists mutualist NNS cord-104317-t30dg6oj 253 18 , , , cord-104317-t30dg6oj 253 19 and and CC cord-104317-t30dg6oj 253 20 significant significant JJ cord-104317-t30dg6oj 253 21 effort effort NN cord-104317-t30dg6oj 253 22 must must MD cord-104317-t30dg6oj 253 23 be be VB cord-104317-t30dg6oj 253 24 made make VBN cord-104317-t30dg6oj 253 25 to to TO cord-104317-t30dg6oj 253 26 discover discover VB cord-104317-t30dg6oj 253 27 and and CC cord-104317-t30dg6oj 253 28 harness harness VB cord-104317-t30dg6oj 253 29 such such JJ cord-104317-t30dg6oj 253 30 potentially potentially RB cord-104317-t30dg6oj 253 31 impactful impactful JJ cord-104317-t30dg6oj 253 32 relationships relationship NNS cord-104317-t30dg6oj 253 33 . . . cord-104317-t30dg6oj 254 1 Moving move VBG cord-104317-t30dg6oj 254 2 forward forward RB cord-104317-t30dg6oj 254 3 , , , cord-104317-t30dg6oj 254 4 consideration consideration NN cord-104317-t30dg6oj 254 5 of of IN cord-104317-t30dg6oj 254 6 the the DT cord-104317-t30dg6oj 254 7 effects effect NNS cord-104317-t30dg6oj 254 8 of of IN cord-104317-t30dg6oj 254 9 the the DT cord-104317-t30dg6oj 254 10 human human JJ cord-104317-t30dg6oj 254 11 virome virome NN cord-104317-t30dg6oj 254 12 will will MD cord-104317-t30dg6oj 254 13 be be VB cord-104317-t30dg6oj 254 14 crucial crucial JJ cord-104317-t30dg6oj 254 15 in in IN cord-104317-t30dg6oj 254 16 disease disease NN cord-104317-t30dg6oj 254 17 treatment treatment NN cord-104317-t30dg6oj 254 18 and and CC cord-104317-t30dg6oj 254 19 discovery discovery NN cord-104317-t30dg6oj 254 20 of of IN cord-104317-t30dg6oj 254 21 disease disease NN cord-104317-t30dg6oj 254 22 etiologies etiology NNS cord-104317-t30dg6oj 254 23 . . . cord-104317-t30dg6oj 255 1 From from IN cord-104317-t30dg6oj 255 2 purely purely RB cord-104317-t30dg6oj 255 3 pathogenic pathogenic JJ cord-104317-t30dg6oj 255 4 viruses virus NNS cord-104317-t30dg6oj 255 5 to to IN cord-104317-t30dg6oj 255 6 those those DT cord-104317-t30dg6oj 255 7 mutualists mutualist NNS cord-104317-t30dg6oj 255 8 helping help VBG cord-104317-t30dg6oj 255 9 humans human NNS cord-104317-t30dg6oj 255 10 adapt adapt VB cord-104317-t30dg6oj 255 11 to to IN cord-104317-t30dg6oj 255 12 their -PRON- PRP$ cord-104317-t30dg6oj 255 13 world world NN cord-104317-t30dg6oj 255 14 , , , cord-104317-t30dg6oj 255 15 the the DT cord-104317-t30dg6oj 255 16 human human JJ cord-104317-t30dg6oj 255 17 virome virome NNP cord-104317-t30dg6oj 255 18 has have VBZ cord-104317-t30dg6oj 255 19 the the DT cord-104317-t30dg6oj 255 20 potential potential NN cord-104317-t30dg6oj 255 21 to to TO cord-104317-t30dg6oj 255 22 lend lend VB cord-104317-t30dg6oj 255 23 insight insight NN cord-104317-t30dg6oj 255 24 into into IN cord-104317-t30dg6oj 255 25 the the DT cord-104317-t30dg6oj 255 26 basic basic JJ cord-104317-t30dg6oj 255 27 and and CC cord-104317-t30dg6oj 255 28 applied applied JJ cord-104317-t30dg6oj 255 29 biology biology NN cord-104317-t30dg6oj 255 30 of of IN cord-104317-t30dg6oj 255 31 human human JJ cord-104317-t30dg6oj 255 32 health health NN cord-104317-t30dg6oj 255 33 . . . cord-104317-t30dg6oj 256 1 In in IN cord-104317-t30dg6oj 256 2 light light NN cord-104317-t30dg6oj 256 3 of of IN cord-104317-t30dg6oj 256 4 this this DT cord-104317-t30dg6oj 256 5 , , , cord-104317-t30dg6oj 256 6 further further JJ cord-104317-t30dg6oj 256 7 exploration exploration NN cord-104317-t30dg6oj 256 8 into into IN cord-104317-t30dg6oj 256 9 the the DT cord-104317-t30dg6oj 256 10 composition composition NN cord-104317-t30dg6oj 256 11 , , , cord-104317-t30dg6oj 256 12 tropism tropism NN cord-104317-t30dg6oj 256 13 , , , cord-104317-t30dg6oj 256 14 and and CC cord-104317-t30dg6oj 256 15 evolution evolution NN cord-104317-t30dg6oj 256 16 of of IN cord-104317-t30dg6oj 256 17 the the DT cord-104317-t30dg6oj 256 18 human human JJ cord-104317-t30dg6oj 256 19 virome virome NN cord-104317-t30dg6oj 256 20 will will MD cord-104317-t30dg6oj 256 21 undoubtedly undoubtedly RB cord-104317-t30dg6oj 256 22 make make VB cord-104317-t30dg6oj 256 23 way way NN cord-104317-t30dg6oj 256 24 for for IN cord-104317-t30dg6oj 256 25 innovations innovation NNS cord-104317-t30dg6oj 256 26 in in IN cord-104317-t30dg6oj 256 27 the the DT cord-104317-t30dg6oj 256 28 treatment treatment NN cord-104317-t30dg6oj 256 29 of of IN cord-104317-t30dg6oj 256 30 human human JJ cord-104317-t30dg6oj 256 31 disease disease NN cord-104317-t30dg6oj 256 32 . . . cord-104317-t30dg6oj 257 1 Throughout throughout IN cord-104317-t30dg6oj 257 2 this this DT cord-104317-t30dg6oj 257 3 manuscript manuscript NN cord-104317-t30dg6oj 257 4 , , , cord-104317-t30dg6oj 257 5 I -PRON- PRP cord-104317-t30dg6oj 257 6 have have VBP cord-104317-t30dg6oj 257 7 assembled assemble VBN cord-104317-t30dg6oj 257 8 the the DT cord-104317-t30dg6oj 257 9 components component NNS cord-104317-t30dg6oj 257 10 of of IN cord-104317-t30dg6oj 257 11 the the DT cord-104317-t30dg6oj 257 12 human human JJ cord-104317-t30dg6oj 257 13 virome virome NN cord-104317-t30dg6oj 257 14 into into IN cord-104317-t30dg6oj 257 15 broad broad JJ cord-104317-t30dg6oj 257 16 classifications classification NNS cord-104317-t30dg6oj 257 17 of of IN cord-104317-t30dg6oj 257 18 Parasitic parasitic JJ cord-104317-t30dg6oj 257 19 , , , cord-104317-t30dg6oj 257 20 Commensal Commensal NNP cord-104317-t30dg6oj 257 21 , , , cord-104317-t30dg6oj 257 22 and and CC cord-104317-t30dg6oj 257 23 Mutualistic Mutualistic NNP cord-104317-t30dg6oj 257 24 . . . cord-104317-t30dg6oj 258 1 While while IN cord-104317-t30dg6oj 258 2 these these DT cord-104317-t30dg6oj 258 3 definitions definition NNS cord-104317-t30dg6oj 258 4 are be VBP cord-104317-t30dg6oj 258 5 logical logical JJ cord-104317-t30dg6oj 258 6 , , , cord-104317-t30dg6oj 258 7 the the DT cord-104317-t30dg6oj 258 8 intermixing intermixing NN cord-104317-t30dg6oj 258 9 of of IN cord-104317-t30dg6oj 258 10 the the DT cord-104317-t30dg6oj 258 11 groups group NNS cord-104317-t30dg6oj 258 12 and and CC cord-104317-t30dg6oj 258 13 exceptions exception NNS cord-104317-t30dg6oj 258 14 to to IN cord-104317-t30dg6oj 258 15 rules rule NNS cord-104317-t30dg6oj 258 16 drives drive VBZ cord-104317-t30dg6oj 258 17 home home RB cord-104317-t30dg6oj 258 18 the the DT cord-104317-t30dg6oj 258 19 point point NN cord-104317-t30dg6oj 258 20 that that IN cord-104317-t30dg6oj 258 21 the the DT cord-104317-t30dg6oj 258 22 virome virome NNP cord-104317-t30dg6oj 258 23 has have VBZ cord-104317-t30dg6oj 258 24 inherent inherent JJ cord-104317-t30dg6oj 258 25 plasticity plasticity NN cord-104317-t30dg6oj 258 26 . . . cord-104317-t30dg6oj 259 1 Disruption disruption NN cord-104317-t30dg6oj 259 2 of of IN cord-104317-t30dg6oj 259 3 the the DT cord-104317-t30dg6oj 259 4 yin yin NNP cord-104317-t30dg6oj 259 5 and and CC cord-104317-t30dg6oj 259 6 yang yang NNP cord-104317-t30dg6oj 259 7 of of IN cord-104317-t30dg6oj 259 8 virus virus NN cord-104317-t30dg6oj 259 9 - - HYPH cord-104317-t30dg6oj 259 10 host host NN cord-104317-t30dg6oj 259 11 interactions interaction NNS cord-104317-t30dg6oj 259 12 can can MD cord-104317-t30dg6oj 259 13 contribute contribute VB cord-104317-t30dg6oj 259 14 to to IN cord-104317-t30dg6oj 259 15 this this DT cord-104317-t30dg6oj 259 16 transitory transitory JJ cord-104317-t30dg6oj 259 17 nature nature NN cord-104317-t30dg6oj 259 18 and and CC cord-104317-t30dg6oj 259 19 may may MD cord-104317-t30dg6oj 259 20 blur blur VB cord-104317-t30dg6oj 259 21 the the DT cord-104317-t30dg6oj 259 22 lines line NNS cord-104317-t30dg6oj 259 23 that that WDT cord-104317-t30dg6oj 259 24 delineate delineate VBP cord-104317-t30dg6oj 259 25 the the DT cord-104317-t30dg6oj 259 26 three three CD cord-104317-t30dg6oj 259 27 main main JJ cord-104317-t30dg6oj 259 28 groups group NNS cord-104317-t30dg6oj 259 29 . . . cord-104317-t30dg6oj 260 1 This this DT cord-104317-t30dg6oj 260 2 acknowledgement acknowledgement NN cord-104317-t30dg6oj 260 3 of of IN cord-104317-t30dg6oj 260 4 convention convention NN cord-104317-t30dg6oj 260 5 and and CC cord-104317-t30dg6oj 260 6 the the DT cord-104317-t30dg6oj 260 7 departures departure NNS cord-104317-t30dg6oj 260 8 from from IN cord-104317-t30dg6oj 260 9 it -PRON- PRP cord-104317-t30dg6oj 260 10 gives give VBZ cord-104317-t30dg6oj 260 11 both both DT cord-104317-t30dg6oj 260 12 structure structure NN cord-104317-t30dg6oj 260 13 and and CC cord-104317-t30dg6oj 260 14 flexibility flexibility NN cord-104317-t30dg6oj 260 15 to to IN cord-104317-t30dg6oj 260 16 this this DT cord-104317-t30dg6oj 260 17 conception conception NN cord-104317-t30dg6oj 260 18 of of IN cord-104317-t30dg6oj 260 19 the the DT cord-104317-t30dg6oj 260 20 human human JJ cord-104317-t30dg6oj 260 21 virome virome NN cord-104317-t30dg6oj 260 22 . . . cord-104317-t30dg6oj 261 1 The the DT cord-104317-t30dg6oj 261 2 culmination culmination NN cord-104317-t30dg6oj 261 3 of of IN cord-104317-t30dg6oj 261 4 these these DT cord-104317-t30dg6oj 261 5 ideas idea NNS cord-104317-t30dg6oj 261 6 provides provide VBZ cord-104317-t30dg6oj 261 7 a a DT cord-104317-t30dg6oj 261 8 template template NN cord-104317-t30dg6oj 261 9 that that WDT cord-104317-t30dg6oj 261 10 identifies identify VBZ cord-104317-t30dg6oj 261 11 gaps gap NNS cord-104317-t30dg6oj 261 12 in in IN cord-104317-t30dg6oj 261 13 our -PRON- PRP$ cord-104317-t30dg6oj 261 14 current current JJ cord-104317-t30dg6oj 261 15 knowledge knowledge NN cord-104317-t30dg6oj 261 16 , , , cord-104317-t30dg6oj 261 17 postulates postulate VBZ cord-104317-t30dg6oj 261 18 interactions interaction NNS cord-104317-t30dg6oj 261 19 that that WDT cord-104317-t30dg6oj 261 20 are be VBP cord-104317-t30dg6oj 261 21 currently currently RB cord-104317-t30dg6oj 261 22 unknown unknown JJ cord-104317-t30dg6oj 261 23 , , , cord-104317-t30dg6oj 261 24 and and CC cord-104317-t30dg6oj 261 25 describes describe VBZ cord-104317-t30dg6oj 261 26 future future JJ cord-104317-t30dg6oj 261 27 areas area NNS cord-104317-t30dg6oj 261 28 of of IN cord-104317-t30dg6oj 261 29 research research NN cord-104317-t30dg6oj 261 30 , , , cord-104317-t30dg6oj 261 31 the the DT cord-104317-t30dg6oj 261 32 results result NNS cord-104317-t30dg6oj 261 33 of of IN cord-104317-t30dg6oj 261 34 which which WDT cord-104317-t30dg6oj 261 35 can can MD cord-104317-t30dg6oj 261 36 then then RB cord-104317-t30dg6oj 261 37 be be VB cord-104317-t30dg6oj 261 38 classified classify VBN cord-104317-t30dg6oj 261 39 in in IN cord-104317-t30dg6oj 261 40 this this DT cord-104317-t30dg6oj 261 41 same same JJ cord-104317-t30dg6oj 261 42 manner manner NN cord-104317-t30dg6oj 261 43 . . . cord-104317-t30dg6oj 262 1 I -PRON- PRP cord-104317-t30dg6oj 262 2 look look VBP cord-104317-t30dg6oj 262 3 on on RP cord-104317-t30dg6oj 262 4 with with IN cord-104317-t30dg6oj 262 5 anticipation anticipation NN cord-104317-t30dg6oj 262 6 to to IN cord-104317-t30dg6oj 262 7 the the DT cord-104317-t30dg6oj 262 8 continuation continuation NN cord-104317-t30dg6oj 262 9 of of IN cord-104317-t30dg6oj 262 10 the the DT cord-104317-t30dg6oj 262 11 scientific scientific JJ cord-104317-t30dg6oj 262 12 soul soul NN cord-104317-t30dg6oj 262 13 search search NN cord-104317-t30dg6oj 262 14 that that WDT cord-104317-t30dg6oj 262 15 is be VBZ cord-104317-t30dg6oj 262 16 the the DT cord-104317-t30dg6oj 262 17 exploration exploration NN cord-104317-t30dg6oj 262 18 of of IN cord-104317-t30dg6oj 262 19 the the DT cord-104317-t30dg6oj 262 20 virome virome NN cord-104317-t30dg6oj 262 21 , , , cord-104317-t30dg6oj 262 22 where where WRB cord-104317-t30dg6oj 262 23 as as IN cord-104317-t30dg6oj 262 24 we -PRON- PRP cord-104317-t30dg6oj 262 25 learn learn VBP cord-104317-t30dg6oj 262 26 more more JJR cord-104317-t30dg6oj 262 27 about about IN cord-104317-t30dg6oj 262 28 viruses virus NNS cord-104317-t30dg6oj 262 29 , , , cord-104317-t30dg6oj 262 30 we -PRON- PRP cord-104317-t30dg6oj 262 31 come come VBP cord-104317-t30dg6oj 262 32 to to TO cord-104317-t30dg6oj 262 33 better better RB cord-104317-t30dg6oj 262 34 know know VB cord-104317-t30dg6oj 262 35 ourselves -PRON- PRP cord-104317-t30dg6oj 262 36 . . . cord-104317-t30dg6oj 263 1 Acknowledgments acknowledgment NNS cord-104317-t30dg6oj 263 2 : : : cord-104317-t30dg6oj 263 3 I -PRON- PRP cord-104317-t30dg6oj 263 4 would would MD cord-104317-t30dg6oj 263 5 like like VB cord-104317-t30dg6oj 263 6 to to TO cord-104317-t30dg6oj 263 7 thank thank VB cord-104317-t30dg6oj 263 8 William William NNP cord-104317-t30dg6oj 263 9 Ruff Ruff NNP cord-104317-t30dg6oj 263 10 for for IN cord-104317-t30dg6oj 263 11 thoughtful thoughtful JJ cord-104317-t30dg6oj 263 12 discussion discussion NN cord-104317-t30dg6oj 263 13 , , , cord-104317-t30dg6oj 263 14 critical critical JJ cord-104317-t30dg6oj 263 15 evaluation evaluation NN cord-104317-t30dg6oj 263 16 , , , cord-104317-t30dg6oj 263 17 and and CC cord-104317-t30dg6oj 263 18 editorial editorial JJ cord-104317-t30dg6oj 263 19 comments comment NNS cord-104317-t30dg6oj 263 20 that that WDT cord-104317-t30dg6oj 263 21 contributed contribute VBD cord-104317-t30dg6oj 263 22 to to IN cord-104317-t30dg6oj 263 23 this this DT cord-104317-t30dg6oj 263 24 manuscript manuscript NN cord-104317-t30dg6oj 263 25 . . . cord-104317-t30dg6oj 264 1 I -PRON- PRP cord-104317-t30dg6oj 264 2 would would MD cord-104317-t30dg6oj 264 3 also also RB cord-104317-t30dg6oj 264 4 like like VB cord-104317-t30dg6oj 264 5 to to TO cord-104317-t30dg6oj 264 6 thank thank VB cord-104317-t30dg6oj 264 7 Clinton Clinton NNP cord-104317-t30dg6oj 264 8 Bradfield Bradfield NNP cord-104317-t30dg6oj 264 9 and and CC cord-104317-t30dg6oj 264 10 John John NNP cord-104317-t30dg6oj 264 11 Ventura Ventura NNP cord-104317-t30dg6oj 264 12 for for IN cord-104317-t30dg6oj 264 13 editorial editorial JJ cord-104317-t30dg6oj 264 14 comments comment NNS cord-104317-t30dg6oj 264 15 and and CC cord-104317-t30dg6oj 264 16 suggestions suggestion NNS cord-104317-t30dg6oj 264 17 . . . cord-104317-t30dg6oj 265 1 This this DT cord-104317-t30dg6oj 265 2 material material NN cord-104317-t30dg6oj 265 3 is be VBZ cord-104317-t30dg6oj 265 4 based base VBN cord-104317-t30dg6oj 265 5 upon upon IN cord-104317-t30dg6oj 265 6 work work NN cord-104317-t30dg6oj 265 7 supported support VBN cord-104317-t30dg6oj 265 8 by by IN cord-104317-t30dg6oj 265 9 the the DT cord-104317-t30dg6oj 265 10 National National NNP cord-104317-t30dg6oj 265 11 Science Science NNP cord-104317-t30dg6oj 265 12 Foundation Foundation NNP cord-104317-t30dg6oj 265 13 Graduate Graduate NNP cord-104317-t30dg6oj 265 14 Research Research NNP cord-104317-t30dg6oj 265 15 Fellowship Fellowship NNP cord-104317-t30dg6oj 265 16 under under IN cord-104317-t30dg6oj 265 17 Grant Grant NNP cord-104317-t30dg6oj 265 18 No No NNP cord-104317-t30dg6oj 265 19 . . . cord-104317-t30dg6oj 265 20 DGE1122492 DGE1122492 NNS cord-104317-t30dg6oj 265 21 . . . cord-104317-t30dg6oj 266 1 Mycoparasitism mycoparasitism NN cord-104317-t30dg6oj 266 2 and and CC cord-104317-t30dg6oj 266 3 plant plant NN cord-104317-t30dg6oj 266 4 disease disease NN cord-104317-t30dg6oj 266 5 control control NN cord-104317-t30dg6oj 267 1 Ome Ome NNP cord-104317-t30dg6oj 267 2 Sweet Sweet NNP cord-104317-t30dg6oj 267 3 ' ' `` cord-104317-t30dg6oj 267 4 Omics Omics NNP cord-104317-t30dg6oj 267 5 -- -- : cord-104317-t30dg6oj 267 6 A a DT cord-104317-t30dg6oj 267 7 Genealogical Genealogical NNP cord-104317-t30dg6oj 267 8 Treasury Treasury NNP cord-104317-t30dg6oj 267 9 of of IN cord-104317-t30dg6oj 267 10 Words Words NNP cord-104317-t30dg6oj 267 11 Global Global NNP cord-104317-t30dg6oj 267 12 Screening Screening NNP cord-104317-t30dg6oj 267 13 for for IN cord-104317-t30dg6oj 267 14 Human human JJ cord-104317-t30dg6oj 267 15 Viral Viral NNP cord-104317-t30dg6oj 267 16 Pathogens Pathogens NNPS cord-104317-t30dg6oj 267 17 . . . cord-104317-t30dg6oj 268 1 Emerg Emerg NNP cord-104317-t30dg6oj 268 2 Infect infect VB cord-104317-t30dg6oj 268 3 Dis Dis NNP cord-104317-t30dg6oj 268 4 . . . cord-104317-t30dg6oj 268 5 Centers Centers NNPS cord-104317-t30dg6oj 268 6 for for IN cord-104317-t30dg6oj 268 7 Disease Disease NNP cord-104317-t30dg6oj 268 8 Control Control NNP cord-104317-t30dg6oj 268 9 and and CC cord-104317-t30dg6oj 268 10 Prevention Prevention NNP cord-104317-t30dg6oj 269 1 The the DT cord-104317-t30dg6oj 269 2 ancient ancient JJ cord-104317-t30dg6oj 269 3 Virus virus NN cord-104317-t30dg6oj 269 4 World World NNP cord-104317-t30dg6oj 269 5 and and CC cord-104317-t30dg6oj 269 6 evolution evolution NN cord-104317-t30dg6oj 269 7 of of IN cord-104317-t30dg6oj 269 8 cells cell NNS cord-104317-t30dg6oj 269 9 International International NNP cord-104317-t30dg6oj 269 10 Human Human NNP cord-104317-t30dg6oj 269 11 Genome Genome NNP cord-104317-t30dg6oj 269 12 Sequencing Sequencing NNP cord-104317-t30dg6oj 269 13 Consortium Consortium NNP cord-104317-t30dg6oj 269 14 . . . cord-104317-t30dg6oj 270 1 Initial initial JJ cord-104317-t30dg6oj 270 2 sequencing sequencing NN cord-104317-t30dg6oj 270 3 and and CC cord-104317-t30dg6oj 270 4 analysis analysis NN cord-104317-t30dg6oj 270 5 of of IN cord-104317-t30dg6oj 270 6 the the DT cord-104317-t30dg6oj 270 7 human human JJ cord-104317-t30dg6oj 270 8 genome genome NN cord-104317-t30dg6oj 271 1 The the DT cord-104317-t30dg6oj 271 2 evolutionary evolutionary JJ cord-104317-t30dg6oj 271 3 genomics genomic NNS cord-104317-t30dg6oj 271 4 of of IN cord-104317-t30dg6oj 271 5 pathogen pathogen NN cord-104317-t30dg6oj 271 6 recombination recombination NN cord-104317-t30dg6oj 271 7 Role role NN cord-104317-t30dg6oj 271 8 of of IN cord-104317-t30dg6oj 271 9 viruses virus NNS cord-104317-t30dg6oj 271 10 in in IN cord-104317-t30dg6oj 271 11 human human JJ cord-104317-t30dg6oj 271 12 evolution evolution NN cord-104317-t30dg6oj 271 13 Evolution evolution NN cord-104317-t30dg6oj 271 14 of of IN cord-104317-t30dg6oj 271 15 complexity complexity NN cord-104317-t30dg6oj 271 16 in in IN cord-104317-t30dg6oj 271 17 the the DT cord-104317-t30dg6oj 271 18 viral viral JJ cord-104317-t30dg6oj 271 19 world world NN cord-104317-t30dg6oj 271 20 : : : cord-104317-t30dg6oj 271 21 The the DT cord-104317-t30dg6oj 271 22 dawn dawn NN cord-104317-t30dg6oj 271 23 of of IN cord-104317-t30dg6oj 271 24 a a DT cord-104317-t30dg6oj 271 25 new new JJ cord-104317-t30dg6oj 271 26 vision vision NN cord-104317-t30dg6oj 271 27 Ten ten CD cord-104317-t30dg6oj 271 28 reasons reason NNS cord-104317-t30dg6oj 271 29 to to TO cord-104317-t30dg6oj 271 30 exclude exclude VB cord-104317-t30dg6oj 271 31 viruses virus NNS cord-104317-t30dg6oj 271 32 from from IN cord-104317-t30dg6oj 271 33 the the DT cord-104317-t30dg6oj 271 34 tree tree NN cord-104317-t30dg6oj 271 35 of of IN cord-104317-t30dg6oj 271 36 life life NN cord-104317-t30dg6oj 271 37 Viral Viral NNP cord-104317-t30dg6oj 271 38 metagenomics metagenomic NNS cord-104317-t30dg6oj 271 39 Experimental experimental JJ cord-104317-t30dg6oj 271 40 and and CC cord-104317-t30dg6oj 271 41 analytical analytical JJ cord-104317-t30dg6oj 271 42 tools tool NNS cord-104317-t30dg6oj 271 43 for for IN cord-104317-t30dg6oj 271 44 studying study VBG cord-104317-t30dg6oj 271 45 the the DT cord-104317-t30dg6oj 271 46 human human JJ cord-104317-t30dg6oj 271 47 microbiome microbiome NN cord-104317-t30dg6oj 271 48 Genomic Genomic NNP cord-104317-t30dg6oj 271 49 approaches approach NNS cord-104317-t30dg6oj 271 50 to to IN cord-104317-t30dg6oj 271 51 studying study VBG cord-104317-t30dg6oj 271 52 the the DT cord-104317-t30dg6oj 271 53 human human JJ cord-104317-t30dg6oj 271 54 microbiota microbiota NN cord-104317-t30dg6oj 272 1 Enhanced enhanced JJ cord-104317-t30dg6oj 272 2 virome virome NN cord-104317-t30dg6oj 272 3 sequencing sequencing NN cord-104317-t30dg6oj 272 4 through through IN cord-104317-t30dg6oj 272 5 solution solution NN cord-104317-t30dg6oj 272 6 - - HYPH cord-104317-t30dg6oj 272 7 based base VBN cord-104317-t30dg6oj 272 8 capture capture NN cord-104317-t30dg6oj 272 9 enrichment enrichment NN cord-104317-t30dg6oj 272 10 Metagenomics Metagenomics NNP cord-104317-t30dg6oj 272 11 - - HYPH cord-104317-t30dg6oj 272 12 driven drive VBN cord-104317-t30dg6oj 272 13 Virome Virome NNP cord-104317-t30dg6oj 272 14 : : : cord-104317-t30dg6oj 273 1 Current current JJ cord-104317-t30dg6oj 273 2 Procedures procedure NNS cord-104317-t30dg6oj 273 3 and and CC cord-104317-t30dg6oj 273 4 New New NNP cord-104317-t30dg6oj 273 5 Additions Additions NNPS cord-104317-t30dg6oj 274 1 The the DT cord-104317-t30dg6oj 274 2 Normal normal JJ cord-104317-t30dg6oj 274 3 Microbial microbial JJ cord-104317-t30dg6oj 274 4 Flora Flora NNP cord-104317-t30dg6oj 274 5 Die die VBP cord-104317-t30dg6oj 274 6 Erscheinung Erscheinung NNP cord-104317-t30dg6oj 274 7 der der NNP cord-104317-t30dg6oj 274 8 Symbiose Symbiose NNP cord-104317-t30dg6oj 274 9 . . . cord-104317-t30dg6oj 275 1 Vor Vor NNP cord-104317-t30dg6oj 275 2 auf auf NNP cord-104317-t30dg6oj 275 3 der der NNP cord-104317-t30dg6oj 275 4 Versammlung Versammlung NNP cord-104317-t30dg6oj 275 5 der der NNP cord-104317-t30dg6oj 275 6 Naturforscher Naturforscher NNP cord-104317-t30dg6oj 276 1 und und NNP cord-104317-t30dg6oj 277 1 Artze Artze NNP cord-104317-t30dg6oj 277 2 zu zu NNP cord-104317-t30dg6oj 277 3 Cassel Cassel NNP cord-104317-t30dg6oj 277 4 Plants Plants NNPS cord-104317-t30dg6oj 277 5 , , , cord-104317-t30dg6oj 277 6 viruses virus NNS cord-104317-t30dg6oj 277 7 and and CC cord-104317-t30dg6oj 277 8 the the DT cord-104317-t30dg6oj 277 9 environment environment NN cord-104317-t30dg6oj 277 10 : : : cord-104317-t30dg6oj 277 11 Ecology ecology NN cord-104317-t30dg6oj 277 12 and and CC cord-104317-t30dg6oj 277 13 mutualism mutualism NN cord-104317-t30dg6oj 278 1 The the DT cord-104317-t30dg6oj 278 2 good good JJ cord-104317-t30dg6oj 278 3 viruses virus NNS cord-104317-t30dg6oj 278 4 : : : cord-104317-t30dg6oj 278 5 viral viral JJ cord-104317-t30dg6oj 278 6 mutualistic mutualistic JJ cord-104317-t30dg6oj 278 7 symbioses symbiose NNS cord-104317-t30dg6oj 278 8 Plant Plant NNP cord-104317-t30dg6oj 278 9 Virus Virus NNP cord-104317-t30dg6oj 278 10 Ecology Ecology NNP cord-104317-t30dg6oj 278 11 Insect Insect NNP cord-104317-t30dg6oj 278 12 symbionts symbiont NNS cord-104317-t30dg6oj 278 13 as as IN cord-104317-t30dg6oj 278 14 hidden hidden JJ cord-104317-t30dg6oj 278 15 players player NNS cord-104317-t30dg6oj 278 16 in in IN cord-104317-t30dg6oj 278 17 insect insect NN cord-104317-t30dg6oj 278 18 - - HYPH cord-104317-t30dg6oj 278 19 plant plant NN cord-104317-t30dg6oj 278 20 interactions interaction NNS cord-104317-t30dg6oj 278 21 Polydnaviruses polydnaviruse NNS cord-104317-t30dg6oj 278 22 of of IN cord-104317-t30dg6oj 278 23 Braconid Braconid NNP cord-104317-t30dg6oj 278 24 Wasps wasp NNS cord-104317-t30dg6oj 278 25 Derive derive VBP cord-104317-t30dg6oj 278 26 from from IN cord-104317-t30dg6oj 278 27 an an DT cord-104317-t30dg6oj 278 28 Suppression suppression NN cord-104317-t30dg6oj 278 29 of of IN cord-104317-t30dg6oj 278 30 Root Root NNP cord-104317-t30dg6oj 278 31 Nodule Nodule NNP cord-104317-t30dg6oj 278 32 Formation Formation NNP cord-104317-t30dg6oj 278 33 by by IN cord-104317-t30dg6oj 278 34 Artificial Artificial NNP cord-104317-t30dg6oj 278 35 Expression Expression NNP cord-104317-t30dg6oj 278 36 of of IN cord-104317-t30dg6oj 278 37 the the DT cord-104317-t30dg6oj 278 38 TrEnodDR1 TrEnodDR1 NNP cord-104317-t30dg6oj 279 1 ( ( -LRB- cord-104317-t30dg6oj 279 2 Coat Coat NNP cord-104317-t30dg6oj 279 3 Protein Protein NNP cord-104317-t30dg6oj 279 4 of of IN cord-104317-t30dg6oj 279 5 White White NNP cord-104317-t30dg6oj 279 6 clover clover NN cord-104317-t30dg6oj 279 7 cryptic cryptic JJ cord-104317-t30dg6oj 279 8 virus virus NN cord-104317-t30dg6oj 279 9 1 1 CD cord-104317-t30dg6oj 279 10 ) ) -RRB- cord-104317-t30dg6oj 279 11 Gene gene NN cord-104317-t30dg6oj 279 12 in in IN cord-104317-t30dg6oj 279 13 Lotus Lotus NNP cord-104317-t30dg6oj 279 14 japonicus japonicus NN cord-104317-t30dg6oj 280 1 The the DT cord-104317-t30dg6oj 280 2 Virome Virome NNP cord-104317-t30dg6oj 280 3 in in IN cord-104317-t30dg6oj 280 4 Host Host NNP cord-104317-t30dg6oj 280 5 Health Health NNP cord-104317-t30dg6oj 280 6 and and CC cord-104317-t30dg6oj 280 7 Disease Disease NNP cord-104317-t30dg6oj 280 8 . . . cord-104317-t30dg6oj 281 1 Immunity immunity NN cord-104317-t30dg6oj 281 2 Move move NN cord-104317-t30dg6oj 281 3 Over over RB cord-104317-t30dg6oj 281 4 , , , cord-104317-t30dg6oj 281 5 Bacteria Bacteria NNS cord-104317-t30dg6oj 281 6 ! ! . cord-104317-t30dg6oj 282 1 Viruses virus NNS cord-104317-t30dg6oj 282 2 Make make VBP cord-104317-t30dg6oj 282 3 Their -PRON- PRP$ cord-104317-t30dg6oj 282 4 Mark mark NN cord-104317-t30dg6oj 282 5 as as IN cord-104317-t30dg6oj 282 6 Mutualistic Mutualistic NNP cord-104317-t30dg6oj 282 7 Microbial microbial JJ cord-104317-t30dg6oj 282 8 Symbionts Symbionts NNPS cord-104317-t30dg6oj 283 1 The the DT cord-104317-t30dg6oj 283 2 human human JJ cord-104317-t30dg6oj 283 3 gut gut NN cord-104317-t30dg6oj 283 4 microbiota microbiota NN cord-104317-t30dg6oj 283 5 and and CC cord-104317-t30dg6oj 283 6 virome virome NN cord-104317-t30dg6oj 283 7 : : : cord-104317-t30dg6oj 283 8 Potential potential JJ cord-104317-t30dg6oj 283 9 therapeutic therapeutic JJ cord-104317-t30dg6oj 283 10 implications implication NNS cord-104317-t30dg6oj 284 1 The the DT cord-104317-t30dg6oj 284 2 virome virome NN cord-104317-t30dg6oj 284 3 in in IN cord-104317-t30dg6oj 284 4 mammalian mammalian JJ cord-104317-t30dg6oj 284 5 physiology physiology NN cord-104317-t30dg6oj 284 6 and and CC cord-104317-t30dg6oj 284 7 disease disease NN cord-104317-t30dg6oj 285 1 The the DT cord-104317-t30dg6oj 285 2 endogenous endogenous JJ cord-104317-t30dg6oj 285 3 retroviral retroviral NN cord-104317-t30dg6oj 285 4 locus locus NN cord-104317-t30dg6oj 285 5 ERVWE1 ERVWE1 NNP cord-104317-t30dg6oj 285 6 is be VBZ cord-104317-t30dg6oj 285 7 a a DT cord-104317-t30dg6oj 285 8 bona bona JJ cord-104317-t30dg6oj 285 9 fide fide JJ cord-104317-t30dg6oj 285 10 gene gene NN cord-104317-t30dg6oj 285 11 involved involve VBN cord-104317-t30dg6oj 285 12 in in IN cord-104317-t30dg6oj 285 13 hominoid hominoid JJ cord-104317-t30dg6oj 285 14 placental placental NN cord-104317-t30dg6oj 285 15 physiology physiology NN cord-104317-t30dg6oj 286 1 The the DT cord-104317-t30dg6oj 286 2 etiology etiology NN cord-104317-t30dg6oj 286 3 of of IN cord-104317-t30dg6oj 286 4 yellow yellow JJ cord-104317-t30dg6oj 286 5 fever fever NN cord-104317-t30dg6oj 286 6 : : : cord-104317-t30dg6oj 286 7 a a DT cord-104317-t30dg6oj 286 8 supplemental supplemental JJ cord-104317-t30dg6oj 286 9 note note NN cord-104317-t30dg6oj 286 10 Human Human NNP cord-104317-t30dg6oj 286 11 Viruses Viruses NNPS cord-104317-t30dg6oj 286 12 and and CC cord-104317-t30dg6oj 286 13 Associated Associated NNP cord-104317-t30dg6oj 286 14 Pathologies Pathologies NNPS cord-104317-t30dg6oj 286 15 Human Human NNP cord-104317-t30dg6oj 286 16 viruses virus NNS cord-104317-t30dg6oj 286 17 : : : cord-104317-t30dg6oj 286 18 discovery discovery NN cord-104317-t30dg6oj 286 19 and and CC cord-104317-t30dg6oj 286 20 emergence emergence NN cord-104317-t30dg6oj 286 21 Discovery Discovery NNP cord-104317-t30dg6oj 286 22 of of IN cord-104317-t30dg6oj 286 23 a a DT cord-104317-t30dg6oj 286 24 Novel Novel NNP cord-104317-t30dg6oj 286 25 Human Human NNP cord-104317-t30dg6oj 286 26 Pegivirus Pegivirus NNP cord-104317-t30dg6oj 286 27 in in IN cord-104317-t30dg6oj 286 28 Blood blood NN cord-104317-t30dg6oj 286 29 Associated Associated NNP cord-104317-t30dg6oj 286 30 with with IN cord-104317-t30dg6oj 286 31 Hepatitis Hepatitis NNP cord-104317-t30dg6oj 286 32 C C NNP cord-104317-t30dg6oj 286 33 Virus Virus NNP cord-104317-t30dg6oj 286 34 Co Co NNP cord-104317-t30dg6oj 286 35 - - NN cord-104317-t30dg6oj 286 36 Infection infection NN cord-104317-t30dg6oj 286 37 A a NN cord-104317-t30dg6oj 287 1 Variegated Variegated NNP cord-104317-t30dg6oj 287 2 Squirrel Squirrel NNP cord-104317-t30dg6oj 287 3 Bornavirus Bornavirus NNP cord-104317-t30dg6oj 287 4 Associated Associated NNP cord-104317-t30dg6oj 287 5 with with IN cord-104317-t30dg6oj 287 6 Fatal fatal JJ cord-104317-t30dg6oj 287 7 Human Human NNP cord-104317-t30dg6oj 287 8 Encephalitis Encephalitis NNP cord-104317-t30dg6oj 287 9 Male male JJ cord-104317-t30dg6oj 287 10 infertility infertility NN cord-104317-t30dg6oj 287 11 : : : cord-104317-t30dg6oj 287 12 a a DT cord-104317-t30dg6oj 287 13 public public JJ cord-104317-t30dg6oj 287 14 health health NN cord-104317-t30dg6oj 287 15 issue issue NN cord-104317-t30dg6oj 287 16 caused cause VBN cord-104317-t30dg6oj 287 17 by by IN cord-104317-t30dg6oj 287 18 sexually sexually RB cord-104317-t30dg6oj 287 19 transmitted transmit VBN cord-104317-t30dg6oj 287 20 pathogens pathogen NNS cord-104317-t30dg6oj 287 21 Infectious Infectious NNP cord-104317-t30dg6oj 287 22 Disease Disease NNP cord-104317-t30dg6oj 287 23 and and CC cord-104317-t30dg6oj 287 24 the the DT cord-104317-t30dg6oj 287 25 Creation creation NN cord-104317-t30dg6oj 287 26 of of IN cord-104317-t30dg6oj 288 1 Culture culture NN cord-104317-t30dg6oj 288 2 An an DT cord-104317-t30dg6oj 288 3 inquiry inquiry NN cord-104317-t30dg6oj 288 4 into into IN cord-104317-t30dg6oj 288 5 the the DT cord-104317-t30dg6oj 288 6 causes cause NNS cord-104317-t30dg6oj 288 7 and and CC cord-104317-t30dg6oj 288 8 effects effect NNS cord-104317-t30dg6oj 288 9 of of IN cord-104317-t30dg6oj 288 10 the the DT cord-104317-t30dg6oj 288 11 variolae variolae NNP cord-104317-t30dg6oj 288 12 vaccinae vaccinae NNP cord-104317-t30dg6oj 288 13 , , , cord-104317-t30dg6oj 288 14 a a DT cord-104317-t30dg6oj 288 15 disease disease NN cord-104317-t30dg6oj 288 16 discovered discover VBN cord-104317-t30dg6oj 288 17 in in IN cord-104317-t30dg6oj 288 18 some some DT cord-104317-t30dg6oj 288 19 of of IN cord-104317-t30dg6oj 288 20 the the DT cord-104317-t30dg6oj 288 21 western western JJ cord-104317-t30dg6oj 288 22 counties county NNS cord-104317-t30dg6oj 288 23 of of IN cord-104317-t30dg6oj 288 24 England England NNP cord-104317-t30dg6oj 288 25 , , , cord-104317-t30dg6oj 288 26 particularly particularly RB cord-104317-t30dg6oj 288 27 Gloucestershire Gloucestershire NNP cord-104317-t30dg6oj 288 28 , , , cord-104317-t30dg6oj 288 29 and and CC cord-104317-t30dg6oj 288 30 known know VBN cord-104317-t30dg6oj 288 31 by by IN cord-104317-t30dg6oj 288 32 the the DT cord-104317-t30dg6oj 288 33 name name NN cord-104317-t30dg6oj 288 34 of of IN cord-104317-t30dg6oj 288 35 the the DT cord-104317-t30dg6oj 288 36 cow cow NN cord-104317-t30dg6oj 288 37 pox pox NN cord-104317-t30dg6oj 288 38 Coevolution Coevolution NNP cord-104317-t30dg6oj 288 39 of of IN cord-104317-t30dg6oj 288 40 hosts host NNS cord-104317-t30dg6oj 288 41 and and CC cord-104317-t30dg6oj 288 42 parasites parasite NNS cord-104317-t30dg6oj 288 43 Vertical vertical JJ cord-104317-t30dg6oj 288 44 transmission transmission NN cord-104317-t30dg6oj 288 45 of of IN cord-104317-t30dg6oj 288 46 viruses virus NNS cord-104317-t30dg6oj 288 47 What what WP cord-104317-t30dg6oj 288 48 is be VBZ cord-104317-t30dg6oj 288 49 a a DT cord-104317-t30dg6oj 288 50 quasispecies quasispecie NNS cord-104317-t30dg6oj 288 51 ? ? . cord-104317-t30dg6oj 289 1 Virulence virulence NN cord-104317-t30dg6oj 289 2 evolution evolution NN cord-104317-t30dg6oj 289 3 in in IN cord-104317-t30dg6oj 289 4 a a DT cord-104317-t30dg6oj 289 5 virus virus NN cord-104317-t30dg6oj 289 6 obeys obey VBZ cord-104317-t30dg6oj 289 7 a a DT cord-104317-t30dg6oj 289 8 trade trade NN cord-104317-t30dg6oj 289 9 - - HYPH cord-104317-t30dg6oj 289 10 off off RP cord-104317-t30dg6oj 289 11 Understanding understand VBG cord-104317-t30dg6oj 289 12 the the DT cord-104317-t30dg6oj 289 13 symptoms symptom NNS cord-104317-t30dg6oj 289 14 of of IN cord-104317-t30dg6oj 289 15 the the DT cord-104317-t30dg6oj 289 16 common common JJ cord-104317-t30dg6oj 289 17 cold cold NN cord-104317-t30dg6oj 289 18 and and CC cord-104317-t30dg6oj 289 19 influenza influenza JJ cord-104317-t30dg6oj 289 20 Time Time NNP cord-104317-t30dg6oj 289 21 Lines Lines NNP cord-104317-t30dg6oj 289 22 of of IN cord-104317-t30dg6oj 289 23 Infection Infection NNP cord-104317-t30dg6oj 289 24 and and CC cord-104317-t30dg6oj 289 25 Disease Disease NNP cord-104317-t30dg6oj 289 26 in in IN cord-104317-t30dg6oj 289 27 Human Human NNP cord-104317-t30dg6oj 289 28 Influenza Influenza NNP cord-104317-t30dg6oj 289 29 : : : cord-104317-t30dg6oj 290 1 A a DT cord-104317-t30dg6oj 290 2 Review Review NNP cord-104317-t30dg6oj 290 3 of of IN cord-104317-t30dg6oj 290 4 Volunteer Volunteer NNP cord-104317-t30dg6oj 290 5 Challenge Challenge NNP cord-104317-t30dg6oj 290 6 Studies Studies NNPS cord-104317-t30dg6oj 291 1 The the DT cord-104317-t30dg6oj 291 2 Pathology Pathology NNP cord-104317-t30dg6oj 291 3 of of IN cord-104317-t30dg6oj 291 4 Influenza Influenza NNP cord-104317-t30dg6oj 291 5 Virus Virus NNP cord-104317-t30dg6oj 291 6 Infections Infections NNPS cord-104317-t30dg6oj 291 7 Bacterial bacterial JJ cord-104317-t30dg6oj 291 8 and and CC cord-104317-t30dg6oj 291 9 viral viral JJ cord-104317-t30dg6oj 291 10 infections infection NNS cord-104317-t30dg6oj 291 11 associated associate VBN cord-104317-t30dg6oj 291 12 with with IN cord-104317-t30dg6oj 291 13 influenza influenza NN cord-104317-t30dg6oj 291 14 Into into IN cord-104317-t30dg6oj 291 15 the the DT cord-104317-t30dg6oj 291 16 Eye Eye NNP cord-104317-t30dg6oj 291 17 of of IN cord-104317-t30dg6oj 291 18 the the DT cord-104317-t30dg6oj 291 19 Cytokine Cytokine NNP cord-104317-t30dg6oj 291 20 Storm Storm NNP cord-104317-t30dg6oj 291 21 Transmission Transmission NNP cord-104317-t30dg6oj 291 22 of of IN cord-104317-t30dg6oj 291 23 Influenza Influenza NNP cord-104317-t30dg6oj 291 24 Virus Virus NNP cord-104317-t30dg6oj 291 25 via via IN cord-104317-t30dg6oj 291 26 Aerosols Aerosols NNPS cord-104317-t30dg6oj 291 27 and and CC cord-104317-t30dg6oj 291 28 Fomites Fomites NNPS cord-104317-t30dg6oj 291 29 in in IN cord-104317-t30dg6oj 291 30 the the DT cord-104317-t30dg6oj 291 31 Guinea Guinea NNP cord-104317-t30dg6oj 291 32 Pig Pig NNP cord-104317-t30dg6oj 291 33 Model Model NNP cord-104317-t30dg6oj 291 34 Medicine Medicine NNP cord-104317-t30dg6oj 291 35 in in IN cord-104317-t30dg6oj 291 36 Ancient Ancient NNP cord-104317-t30dg6oj 291 37 Egypt Egypt NNP cord-104317-t30dg6oj 291 38 . . . cord-104317-t30dg6oj 292 1 Med Med NNP cord-104317-t30dg6oj 292 2 Across Across NNP cord-104317-t30dg6oj 292 3 Cult Cult NNP cord-104317-t30dg6oj 292 4 Origin Origin NNP cord-104317-t30dg6oj 292 5 of of IN cord-104317-t30dg6oj 292 6 measles measles NNP cord-104317-t30dg6oj 292 7 virus virus NN cord-104317-t30dg6oj 292 8 : : : cord-104317-t30dg6oj 292 9 divergence divergence NN cord-104317-t30dg6oj 292 10 from from IN cord-104317-t30dg6oj 292 11 rinderpest rinderpest NN cord-104317-t30dg6oj 292 12 virus virus NN cord-104317-t30dg6oj 292 13 between between IN cord-104317-t30dg6oj 292 14 the the DT cord-104317-t30dg6oj 292 15 11(th)and 11(th)and CD cord-104317-t30dg6oj 292 16 12(th)centuries 12(th)centuries CD cord-104317-t30dg6oj 292 17 From from IN cord-104317-t30dg6oj 292 18 Contagium Contagium NNP cord-104317-t30dg6oj 292 19 Fluidum Fluidum NNP cord-104317-t30dg6oj 292 20 to to IN cord-104317-t30dg6oj 292 21 Virome Virome NNP cord-104317-t30dg6oj 292 22 Persistent persistent JJ cord-104317-t30dg6oj 292 23 Viral viral JJ cord-104317-t30dg6oj 292 24 Infections infection NNS cord-104317-t30dg6oj 292 25 Redefining redefine VBG cord-104317-t30dg6oj 292 26 Chronic chronic JJ cord-104317-t30dg6oj 292 27 Viral viral JJ cord-104317-t30dg6oj 292 28 Infection infection NN cord-104317-t30dg6oj 292 29 Fields field NNS cord-104317-t30dg6oj 292 30 Virol Virol NNP cord-104317-t30dg6oj 292 31 Global Global NNP cord-104317-t30dg6oj 292 32 and and CC cord-104317-t30dg6oj 292 33 Regional Regional NNP cord-104317-t30dg6oj 292 34 Estimates estimate NNS cord-104317-t30dg6oj 292 35 of of IN cord-104317-t30dg6oj 292 36 Prevalent Prevalent NNP cord-104317-t30dg6oj 292 37 and and CC cord-104317-t30dg6oj 292 38 Incident Incident NNP cord-104317-t30dg6oj 292 39 Herpes Herpes NNP cord-104317-t30dg6oj 292 40 Simplex Simplex NNP cord-104317-t30dg6oj 292 41 Virus Virus NNP cord-104317-t30dg6oj 292 42 Type Type NNP cord-104317-t30dg6oj 292 43 1 1 CD cord-104317-t30dg6oj 292 44 Infections infection NNS cord-104317-t30dg6oj 292 45 in in IN cord-104317-t30dg6oj 292 46 2012 2012 CD cord-104317-t30dg6oj 293 1 The the DT cord-104317-t30dg6oj 293 2 Natural natural JJ cord-104317-t30dg6oj 293 3 History history NN cord-104317-t30dg6oj 293 4 of of IN cord-104317-t30dg6oj 293 5 Hepatitis Hepatitis NNP cord-104317-t30dg6oj 293 6 C C NNP cord-104317-t30dg6oj 293 7 Virus Virus NNP cord-104317-t30dg6oj 293 8 ( ( -LRB- cord-104317-t30dg6oj 293 9 HCV HCV NNP cord-104317-t30dg6oj 293 10 ) ) -RRB- cord-104317-t30dg6oj 293 11 Infection Infection NNP cord-104317-t30dg6oj 293 12 Screening Screening NNP cord-104317-t30dg6oj 293 13 Blood blood NN cord-104317-t30dg6oj 293 14 : : : cord-104317-t30dg6oj 294 1 Public Public NNP cord-104317-t30dg6oj 294 2 Health Health NNP cord-104317-t30dg6oj 294 3 and and CC cord-104317-t30dg6oj 294 4 Medical Medical NNP cord-104317-t30dg6oj 294 5 Uncertainty Uncertainty NNP cord-104317-t30dg6oj 294 6 Current Current NNP cord-104317-t30dg6oj 294 7 and and CC cord-104317-t30dg6oj 294 8 emerging emerge VBG cord-104317-t30dg6oj 294 9 infectious infectious JJ cord-104317-t30dg6oj 294 10 risks risk NNS cord-104317-t30dg6oj 294 11 of of IN cord-104317-t30dg6oj 294 12 blood blood NN cord-104317-t30dg6oj 294 13 transfusions transfusion NNS cord-104317-t30dg6oj 294 14 AIDS AIDS NNP cord-104317-t30dg6oj 294 15 pathogenesis pathogenesis NN cord-104317-t30dg6oj 294 16 : : : cord-104317-t30dg6oj 294 17 what what WP cord-104317-t30dg6oj 294 18 have have VBP cord-104317-t30dg6oj 294 19 two two CD cord-104317-t30dg6oj 294 20 decades decade NNS cord-104317-t30dg6oj 294 21 of of IN cord-104317-t30dg6oj 294 22 HIV HIV NNP cord-104317-t30dg6oj 294 23 research research NN cord-104317-t30dg6oj 294 24 taught teach VBD cord-104317-t30dg6oj 294 25 us -PRON- PRP cord-104317-t30dg6oj 294 26 ? ? . cord-104317-t30dg6oj 295 1 Hepatitis Hepatitis NNP cord-104317-t30dg6oj 295 2 C C NNP cord-104317-t30dg6oj 295 3 virus virus NN cord-104317-t30dg6oj 295 4 contributes contribute VBZ cord-104317-t30dg6oj 295 5 to to IN cord-104317-t30dg6oj 295 6 hepatocarcinogenesis hepatocarcinogenesis NNP cord-104317-t30dg6oj 295 7 by by IN cord-104317-t30dg6oj 295 8 modulating modulate VBG cord-104317-t30dg6oj 295 9 metabolic metabolic JJ cord-104317-t30dg6oj 295 10 and and CC cord-104317-t30dg6oj 295 11 intracellular intracellular JJ cord-104317-t30dg6oj 295 12 signaling signal VBG cord-104317-t30dg6oj 295 13 pathways pathway NNS cord-104317-t30dg6oj 295 14 Association Association NNP cord-104317-t30dg6oj 295 15 Between between IN cord-104317-t30dg6oj 295 16 Hepatitis Hepatitis NNP cord-104317-t30dg6oj 295 17 C C NNP cord-104317-t30dg6oj 295 18 and and CC cord-104317-t30dg6oj 295 19 Hepatocellular Hepatocellular NNP cord-104317-t30dg6oj 295 20 Carcinoma Carcinoma NNP cord-104317-t30dg6oj 295 21 Endogenous endogenous JJ cord-104317-t30dg6oj 295 22 Retroviruses Retroviruses NNPS cord-104317-t30dg6oj 295 23 , , , cord-104317-t30dg6oj 295 24 and and CC cord-104317-t30dg6oj 295 25 the the DT cord-104317-t30dg6oj 295 26 Evolution evolution NN cord-104317-t30dg6oj 295 27 of of IN cord-104317-t30dg6oj 295 28 Retroelements Retroelements NNP cord-104317-t30dg6oj 295 29 Human Human NNP cord-104317-t30dg6oj 295 30 endogenous endogenous JJ cord-104317-t30dg6oj 295 31 retrovirus retrovirus NN cord-104317-t30dg6oj 295 32 glycoprotein glycoprotein NN cord-104317-t30dg6oj 295 33 - - HYPH cord-104317-t30dg6oj 295 34 mediated mediate VBN cord-104317-t30dg6oj 295 35 induction induction NN cord-104317-t30dg6oj 295 36 of of IN cord-104317-t30dg6oj 295 37 redox redox JJ cord-104317-t30dg6oj 295 38 reactants reactant NNS cord-104317-t30dg6oj 295 39 causes cause VBZ cord-104317-t30dg6oj 295 40 oligodendrocyte oligodendrocyte NNP cord-104317-t30dg6oj 295 41 death death NN cord-104317-t30dg6oj 295 42 and and CC cord-104317-t30dg6oj 295 43 demyelination demyelination NN cord-104317-t30dg6oj 296 1 The the DT cord-104317-t30dg6oj 296 2 enemy enemy NN cord-104317-t30dg6oj 296 3 within within IN cord-104317-t30dg6oj 296 4 : : : cord-104317-t30dg6oj 296 5 endogenous endogenous JJ cord-104317-t30dg6oj 296 6 retroelements retroelement NNS cord-104317-t30dg6oj 296 7 and and CC cord-104317-t30dg6oj 296 8 autoimmune autoimmune JJ cord-104317-t30dg6oj 296 9 disease disease NN cord-104317-t30dg6oj 297 1 The the DT cord-104317-t30dg6oj 297 2 potential potential JJ cord-104317-t30dg6oj 297 3 role role NN cord-104317-t30dg6oj 297 4 of of IN cord-104317-t30dg6oj 297 5 retroviruses retrovirus NNS cord-104317-t30dg6oj 297 6 in in IN cord-104317-t30dg6oj 297 7 autoimmunity autoimmunity NN cord-104317-t30dg6oj 297 8 Human human JJ cord-104317-t30dg6oj 297 9 endogenous endogenous JJ cord-104317-t30dg6oj 297 10 retrovirus retrovirus NN cord-104317-t30dg6oj 297 11 rec rec NN cord-104317-t30dg6oj 297 12 interferes interfere VBZ cord-104317-t30dg6oj 297 13 with with IN cord-104317-t30dg6oj 297 14 germ germ NN cord-104317-t30dg6oj 297 15 cell cell NN cord-104317-t30dg6oj 297 16 development development NN cord-104317-t30dg6oj 297 17 in in IN cord-104317-t30dg6oj 297 18 mice mouse NNS cord-104317-t30dg6oj 297 19 and and CC cord-104317-t30dg6oj 297 20 may may MD cord-104317-t30dg6oj 297 21 cause cause VB cord-104317-t30dg6oj 297 22 carcinoma carcinoma NN cord-104317-t30dg6oj 297 23 in in IN cord-104317-t30dg6oj 297 24 situ situ NN cord-104317-t30dg6oj 297 25 , , , cord-104317-t30dg6oj 297 26 the the DT cord-104317-t30dg6oj 297 27 predecessor predecessor NN cord-104317-t30dg6oj 297 28 lesion lesion NN cord-104317-t30dg6oj 297 29 of of IN cord-104317-t30dg6oj 297 30 germ germ NN cord-104317-t30dg6oj 297 31 cell cell NN cord-104317-t30dg6oj 297 32 tumors tumor NNS cord-104317-t30dg6oj 297 33 Exploiting exploit VBG cord-104317-t30dg6oj 297 34 gut gut NN cord-104317-t30dg6oj 297 35 bacteriophages bacteriophage NNS cord-104317-t30dg6oj 297 36 for for IN cord-104317-t30dg6oj 297 37 human human JJ cord-104317-t30dg6oj 297 38 health health NN cord-104317-t30dg6oj 298 1 The the DT cord-104317-t30dg6oj 298 2 development development NN cord-104317-t30dg6oj 298 3 of of IN cord-104317-t30dg6oj 298 4 the the DT cord-104317-t30dg6oj 298 5 phage phage NN cord-104317-t30dg6oj 298 6 - - HYPH cord-104317-t30dg6oj 298 7 inactivating inactivate VBG cord-104317-t30dg6oj 298 8 properties property NNS cord-104317-t30dg6oj 298 9 of of IN cord-104317-t30dg6oj 298 10 serum serum NN cord-104317-t30dg6oj 298 11 during during IN cord-104317-t30dg6oj 298 12 the the DT cord-104317-t30dg6oj 298 13 course course NN cord-104317-t30dg6oj 298 14 of of IN cord-104317-t30dg6oj 298 15 specific specific JJ cord-104317-t30dg6oj 298 16 immunization immunization NN cord-104317-t30dg6oj 298 17 of of IN cord-104317-t30dg6oj 298 18 an an DT cord-104317-t30dg6oj 298 19 animal animal NN cord-104317-t30dg6oj 298 20 : : : cord-104317-t30dg6oj 298 21 reversible reversible JJ cord-104317-t30dg6oj 298 22 and and CC cord-104317-t30dg6oj 298 23 irreversible irreversible JJ cord-104317-t30dg6oj 298 24 inactivation inactivation NN cord-104317-t30dg6oj 298 25 Prevention prevention NN cord-104317-t30dg6oj 298 26 of of IN cord-104317-t30dg6oj 298 27 Staphylococcal Staphylococcal NNP cord-104317-t30dg6oj 298 28 Bacteriophage Bacteriophage NNP cord-104317-t30dg6oj 298 29 Activity Activity NNP cord-104317-t30dg6oj 298 30 by by IN cord-104317-t30dg6oj 298 31 Antigen Antigen NNP cord-104317-t30dg6oj 298 32 A A NNP cord-104317-t30dg6oj 298 33 Precipitins Precipitins NNP cord-104317-t30dg6oj 298 34 in in IN cord-104317-t30dg6oj 298 35 Human Human NNP cord-104317-t30dg6oj 298 36 Sera Sera NNP cord-104317-t30dg6oj 299 1 The the DT cord-104317-t30dg6oj 299 2 recognition recognition NN cord-104317-t30dg6oj 299 3 and and CC cord-104317-t30dg6oj 299 4 classification classification NN cord-104317-t30dg6oj 299 5 of of IN cord-104317-t30dg6oj 299 6 immunodeficiency immunodeficiency NN cord-104317-t30dg6oj 299 7 diseases disease NNS cord-104317-t30dg6oj 299 8 with with IN cord-104317-t30dg6oj 299 9 bacteriophage bacteriophage NN cord-104317-t30dg6oj 299 10 phiChi phiChi NNP cord-104317-t30dg6oj 299 11 174 174 CD cord-104317-t30dg6oj 299 12 Immunogenic immunogenic JJ cord-104317-t30dg6oj 299 13 effect effect NN cord-104317-t30dg6oj 299 14 of of IN cord-104317-t30dg6oj 299 15 bacteriophage bacteriophage NN cord-104317-t30dg6oj 299 16 in in IN cord-104317-t30dg6oj 299 17 patients patient NNS cord-104317-t30dg6oj 299 18 subjected subject VBN cord-104317-t30dg6oj 299 19 to to IN cord-104317-t30dg6oj 299 20 phage phage NN cord-104317-t30dg6oj 299 21 therapy therapy NN cord-104317-t30dg6oj 300 1 Some some DT cord-104317-t30dg6oj 300 2 properties property NNS cord-104317-t30dg6oj 300 3 of of IN cord-104317-t30dg6oj 300 4 dendritic dendritic JJ cord-104317-t30dg6oj 300 5 macrophages macrophage NNS cord-104317-t30dg6oj 300 6 from from IN cord-104317-t30dg6oj 300 7 peripheral peripheral JJ cord-104317-t30dg6oj 300 8 lymph lymph NN cord-104317-t30dg6oj 300 9 Toll toll NN cord-104317-t30dg6oj 300 10 - - HYPH cord-104317-t30dg6oj 300 11 like like JJ cord-104317-t30dg6oj 300 12 receptors receptor NNS cord-104317-t30dg6oj 300 13 in in IN cord-104317-t30dg6oj 300 14 systemic systemic JJ cord-104317-t30dg6oj 300 15 autoimmune autoimmune JJ cord-104317-t30dg6oj 300 16 disease disease NN cord-104317-t30dg6oj 301 1 Toll toll NN cord-104317-t30dg6oj 301 2 - - HYPH cord-104317-t30dg6oj 301 3 like like JJ cord-104317-t30dg6oj 301 4 Receptor Receptor NNP cord-104317-t30dg6oj 301 5 9-Dependent 9-Dependent NNP cord-104317-t30dg6oj 301 6 and and CC cord-104317-t30dg6oj 301 7 -Independent -Independent . cord-104317-t30dg6oj 301 8 Dendritic Dendritic NNP cord-104317-t30dg6oj 301 9 Cell Cell NNP cord-104317-t30dg6oj 301 10 Activation Activation NNP cord-104317-t30dg6oj 301 11 by by IN cord-104317-t30dg6oj 301 12 Chromatin Chromatin NNP cord-104317-t30dg6oj 301 13 - - HYPH cord-104317-t30dg6oj 301 14 Immunoglobulin Immunoglobulin NNP cord-104317-t30dg6oj 301 15 G G NNP cord-104317-t30dg6oj 301 16 Complexes Complexes NNP cord-104317-t30dg6oj 301 17 U1 U1 NNP cord-104317-t30dg6oj 301 18 small small JJ cord-104317-t30dg6oj 301 19 nuclear nuclear JJ cord-104317-t30dg6oj 301 20 ribonucleoprotein ribonucleoprotein NN cord-104317-t30dg6oj 301 21 immune immune JJ cord-104317-t30dg6oj 301 22 complexes complex NNS cord-104317-t30dg6oj 301 23 induce induce VBP cord-104317-t30dg6oj 301 24 type type NN cord-104317-t30dg6oj 302 1 I -PRON- PRP cord-104317-t30dg6oj 302 2 interferon interferon VBD cord-104317-t30dg6oj 302 3 in in IN cord-104317-t30dg6oj 302 4 plasmacytoid plasmacytoid NNP cord-104317-t30dg6oj 302 5 dendritic dendritic JJ cord-104317-t30dg6oj 302 6 cells cell NNS cord-104317-t30dg6oj 302 7 through through IN cord-104317-t30dg6oj 302 8 TLR7 TLR7 NNP cord-104317-t30dg6oj 302 9 Holobiont Holobiont NNP cord-104317-t30dg6oj 302 10 - - HYPH cord-104317-t30dg6oj 302 11 Holobiont Holobiont NNP cord-104317-t30dg6oj 302 12 Interactions interaction NNS cord-104317-t30dg6oj 303 1 : : : cord-104317-t30dg6oj 303 2 Redefining redefine VBG cord-104317-t30dg6oj 303 3 Host host JJ cord-104317-t30dg6oj 303 4 - - HYPH cord-104317-t30dg6oj 303 5 Parasite Parasite NNP cord-104317-t30dg6oj 303 6 Interactions Interactions NNPS cord-104317-t30dg6oj 303 7 Leishmania Leishmania NNP cord-104317-t30dg6oj 303 8 RNA RNA NNP cord-104317-t30dg6oj 303 9 Virus Virus NNP cord-104317-t30dg6oj 303 10 Controls control VBZ cord-104317-t30dg6oj 303 11 the the DT cord-104317-t30dg6oj 303 12 Severity severity NN cord-104317-t30dg6oj 303 13 of of IN cord-104317-t30dg6oj 303 14 Mucocutaneous Mucocutaneous NNP cord-104317-t30dg6oj 303 15 Leishmaniasis leishmaniasis NN cord-104317-t30dg6oj 303 16 Endobiont Endobiont NNP cord-104317-t30dg6oj 303 17 Viruses virus NNS cord-104317-t30dg6oj 303 18 Sensed sense VBN cord-104317-t30dg6oj 303 19 by by IN cord-104317-t30dg6oj 303 20 the the DT cord-104317-t30dg6oj 303 21 Human Human NNP cord-104317-t30dg6oj 303 22 Host Host NNP cord-104317-t30dg6oj 303 23 -Beyond -Beyond . cord-104317-t30dg6oj 303 24 Conventional Conventional NNP cord-104317-t30dg6oj 303 25 Antiparasitic Antiparasitic NNP cord-104317-t30dg6oj 303 26 Therapy Therapy NNP cord-104317-t30dg6oj 303 27 Host Host NNP cord-104317-t30dg6oj 303 28 - - HYPH cord-104317-t30dg6oj 303 29 Pathogen Pathogen NNP cord-104317-t30dg6oj 303 30 Interactions Interactions NNPS cord-104317-t30dg6oj 303 31 : : : cord-104317-t30dg6oj 304 1 Basic basic JJ cord-104317-t30dg6oj 304 2 Concepts concept NNS cord-104317-t30dg6oj 304 3 of of IN cord-104317-t30dg6oj 304 4 Microbial Microbial NNP cord-104317-t30dg6oj 304 5 Commensalism Commensalism NNP cord-104317-t30dg6oj 304 6 , , , cord-104317-t30dg6oj 304 7 Colonization Colonization NNP cord-104317-t30dg6oj 304 8 , , , cord-104317-t30dg6oj 304 9 Infection Infection NNP cord-104317-t30dg6oj 304 10 , , , cord-104317-t30dg6oj 304 11 and and CC cord-104317-t30dg6oj 304 12 Disease Disease NNP cord-104317-t30dg6oj 305 1 The the DT cord-104317-t30dg6oj 305 2 normal normal JJ cord-104317-t30dg6oj 305 3 microflora microflora NN cord-104317-t30dg6oj 305 4 : : : cord-104317-t30dg6oj 305 5 an an DT cord-104317-t30dg6oj 305 6 introduction introduction NN cord-104317-t30dg6oj 305 7 Human Human NNP cord-104317-t30dg6oj 305 8 picornavirus picornavirus NN cord-104317-t30dg6oj 305 9 and and CC cord-104317-t30dg6oj 305 10 coronavirus coronavirus NN cord-104317-t30dg6oj 305 11 RNA RNA NNP cord-104317-t30dg6oj 305 12 in in IN cord-104317-t30dg6oj 305 13 nasopharynx nasopharynx NN cord-104317-t30dg6oj 305 14 of of IN cord-104317-t30dg6oj 305 15 children child NNS cord-104317-t30dg6oj 305 16 without without IN cord-104317-t30dg6oj 305 17 concurrent concurrent JJ cord-104317-t30dg6oj 305 18 respiratory respiratory JJ cord-104317-t30dg6oj 305 19 symptoms symptom NNS cord-104317-t30dg6oj 305 20 RNA RNA NNP cord-104317-t30dg6oj 305 21 Viral Viral NNP cord-104317-t30dg6oj 305 22 Community Community NNP cord-104317-t30dg6oj 305 23 in in IN cord-104317-t30dg6oj 305 24 Human Human NNP cord-104317-t30dg6oj 305 25 Feces fece NNS cord-104317-t30dg6oj 305 26 : : : cord-104317-t30dg6oj 305 27 Prevalence prevalence NN cord-104317-t30dg6oj 305 28 of of IN cord-104317-t30dg6oj 305 29 Plant plant NN cord-104317-t30dg6oj 305 30 Pathogenic pathogenic JJ cord-104317-t30dg6oj 305 31 Viruses virus NNS cord-104317-t30dg6oj 305 32 Viruses virus NNS cord-104317-t30dg6oj 305 33 in in IN cord-104317-t30dg6oj 305 34 the the DT cord-104317-t30dg6oj 305 35 fecal fecal JJ cord-104317-t30dg6oj 305 36 microbiota microbiota NN cord-104317-t30dg6oj 305 37 of of IN cord-104317-t30dg6oj 305 38 monozygotic monozygotic JJ cord-104317-t30dg6oj 305 39 twins twin NNS cord-104317-t30dg6oj 305 40 and and CC cord-104317-t30dg6oj 305 41 their -PRON- PRP$ cord-104317-t30dg6oj 305 42 mothers mother NNS cord-104317-t30dg6oj 305 43 Variability Variability NNP cord-104317-t30dg6oj 305 44 and and CC cord-104317-t30dg6oj 305 45 Diversity Diversity NNP cord-104317-t30dg6oj 305 46 of of IN cord-104317-t30dg6oj 305 47 Nasopharyngeal Nasopharyngeal NNP cord-104317-t30dg6oj 305 48 Microbiota Microbiota NNP cord-104317-t30dg6oj 305 49 in in IN cord-104317-t30dg6oj 305 50 Children Children NNPS cord-104317-t30dg6oj 305 51 : : : cord-104317-t30dg6oj 306 1 A a DT cord-104317-t30dg6oj 306 2 Metagenomic Metagenomic NNP cord-104317-t30dg6oj 306 3 Analysis Analysis NNP cord-104317-t30dg6oj 307 1 The the DT cord-104317-t30dg6oj 307 2 human human JJ cord-104317-t30dg6oj 307 3 gut gut NN cord-104317-t30dg6oj 307 4 virome virome NNP cord-104317-t30dg6oj 307 5 : : : cord-104317-t30dg6oj 308 1 Inter inter JJ cord-104317-t30dg6oj 308 2 - - JJ cord-104317-t30dg6oj 308 3 individual individual JJ cord-104317-t30dg6oj 308 4 variation variation NN cord-104317-t30dg6oj 308 5 and and CC cord-104317-t30dg6oj 308 6 dynamic dynamic JJ cord-104317-t30dg6oj 308 7 response response NN cord-104317-t30dg6oj 308 8 to to TO cord-104317-t30dg6oj 308 9 diet diet VB cord-104317-t30dg6oj 308 10 Merkel Merkel NNP cord-104317-t30dg6oj 308 11 Cell Cell NNP cord-104317-t30dg6oj 308 12 Polyomavirus Polyomavirus NNP cord-104317-t30dg6oj 308 13 and and CC cord-104317-t30dg6oj 308 14 Two two CD cord-104317-t30dg6oj 308 15 Novel Novel NNP cord-104317-t30dg6oj 308 16 Polyomaviruses Polyomaviruses NNPS cord-104317-t30dg6oj 308 17 Are be VBP cord-104317-t30dg6oj 308 18 Chronically chronically RB cord-104317-t30dg6oj 308 19 Shed shed VBN cord-104317-t30dg6oj 308 20 from from IN cord-104317-t30dg6oj 308 21 Human Human NNP cord-104317-t30dg6oj 308 22 Skin skin NN cord-104317-t30dg6oj 308 23 Human human NN cord-104317-t30dg6oj 308 24 Skin skin NN cord-104317-t30dg6oj 308 25 Microbiota Microbiota NNP cord-104317-t30dg6oj 308 26 : : : cord-104317-t30dg6oj 308 27 High high JJ cord-104317-t30dg6oj 308 28 Diversity diversity NN cord-104317-t30dg6oj 308 29 of of IN cord-104317-t30dg6oj 308 30 DNA dna NN cord-104317-t30dg6oj 308 31 Viruses virus NNS cord-104317-t30dg6oj 308 32 Identified identify VBN cord-104317-t30dg6oj 308 33 on on IN cord-104317-t30dg6oj 308 34 the the DT cord-104317-t30dg6oj 308 35 Human human JJ cord-104317-t30dg6oj 308 36 Skin skin NN cord-104317-t30dg6oj 308 37 by by IN cord-104317-t30dg6oj 308 38 Evidence evidence NN cord-104317-t30dg6oj 308 39 of of IN cord-104317-t30dg6oj 308 40 a a DT cord-104317-t30dg6oj 308 41 robust robust JJ cord-104317-t30dg6oj 308 42 resident resident JJ cord-104317-t30dg6oj 308 43 bacteriophage bacteriophage NN cord-104317-t30dg6oj 308 44 population population NN cord-104317-t30dg6oj 308 45 revealed reveal VBD cord-104317-t30dg6oj 308 46 through through IN cord-104317-t30dg6oj 308 47 analysis analysis NN cord-104317-t30dg6oj 308 48 of of IN cord-104317-t30dg6oj 308 49 the the DT cord-104317-t30dg6oj 308 50 human human JJ cord-104317-t30dg6oj 308 51 salivary salivary NN cord-104317-t30dg6oj 308 52 virome virome NNP cord-104317-t30dg6oj 308 53 Resident Resident NNP cord-104317-t30dg6oj 308 54 viruses virus NNS cord-104317-t30dg6oj 308 55 and and CC cord-104317-t30dg6oj 308 56 their -PRON- PRP$ cord-104317-t30dg6oj 308 57 interactions interaction NNS cord-104317-t30dg6oj 308 58 with with IN cord-104317-t30dg6oj 308 59 the the DT cord-104317-t30dg6oj 308 60 immune immune JJ cord-104317-t30dg6oj 308 61 system system NN cord-104317-t30dg6oj 308 62 Pros pro NNS cord-104317-t30dg6oj 308 63 and and CC cord-104317-t30dg6oj 308 64 cons con NNS cord-104317-t30dg6oj 308 65 of of IN cord-104317-t30dg6oj 308 66 phage phage NN cord-104317-t30dg6oj 308 67 therapy therapy NN cord-104317-t30dg6oj 308 68 Phage Phage NNP cord-104317-t30dg6oj 308 69 treatment treatment NN cord-104317-t30dg6oj 308 70 of of IN cord-104317-t30dg6oj 308 71 human human JJ cord-104317-t30dg6oj 308 72 infections infection NNS cord-104317-t30dg6oj 309 1 Phage Phage NNP cord-104317-t30dg6oj 309 2 Therapy Therapy NNP cord-104317-t30dg6oj 309 3 in in IN cord-104317-t30dg6oj 309 4 the the DT cord-104317-t30dg6oj 309 5 Food Food NNP cord-104317-t30dg6oj 309 6 Industry Industry NNP cord-104317-t30dg6oj 309 7 Complete complete JJ cord-104317-t30dg6oj 309 8 nucleotide nucleotide JJ cord-104317-t30dg6oj 309 9 sequences sequence NNS cord-104317-t30dg6oj 309 10 of of IN cord-104317-t30dg6oj 309 11 four four CD cord-104317-t30dg6oj 309 12 dsRNAs dsRNAs NNPS cord-104317-t30dg6oj 309 13 associated associate VBN cord-104317-t30dg6oj 309 14 with with IN cord-104317-t30dg6oj 309 15 a a DT cord-104317-t30dg6oj 309 16 new new JJ cord-104317-t30dg6oj 309 17 chrysovirus chrysovirus NN cord-104317-t30dg6oj 309 18 infecting infect VBG cord-104317-t30dg6oj 309 19 Aspergillus Aspergillus NNP cord-104317-t30dg6oj 309 20 fumigatus fumigatus NN cord-104317-t30dg6oj 309 21 Mycoviruses mycoviruse NNS cord-104317-t30dg6oj 309 22 : : : cord-104317-t30dg6oj 309 23 future future JJ cord-104317-t30dg6oj 309 24 therapeutic therapeutic JJ cord-104317-t30dg6oj 309 25 agents agent NNS cord-104317-t30dg6oj 309 26 of of IN cord-104317-t30dg6oj 309 27 invasive invasive JJ cord-104317-t30dg6oj 309 28 fungal fungal JJ cord-104317-t30dg6oj 309 29 infections infection NNS cord-104317-t30dg6oj 309 30 in in IN cord-104317-t30dg6oj 309 31 humans human NNS cord-104317-t30dg6oj 309 32 ? ? . cord-104317-t30dg6oj 310 1 Complete complete JJ cord-104317-t30dg6oj 310 2 nucleotide nucleotide JJ cord-104317-t30dg6oj 310 3 sequences sequence NNS cord-104317-t30dg6oj 310 4 of of IN cord-104317-t30dg6oj 310 5 two two CD cord-104317-t30dg6oj 310 6 dsRNAs dsrna NNS cord-104317-t30dg6oj 310 7 associated associate VBN cord-104317-t30dg6oj 310 8 with with IN cord-104317-t30dg6oj 310 9 a a DT cord-104317-t30dg6oj 310 10 new new JJ cord-104317-t30dg6oj 310 11 partitivirus partitivirus NN cord-104317-t30dg6oj 310 12 infecting infect VBG cord-104317-t30dg6oj 310 13 Aspergillus aspergillus NN cord-104317-t30dg6oj 310 14 fumigatus fumigatus NN cord-104317-t30dg6oj 310 15 Double Double NNP cord-104317-t30dg6oj 310 16 - - HYPH cord-104317-t30dg6oj 310 17 Stranded strand VBN cord-104317-t30dg6oj 310 18 RNA RNA NNP cord-104317-t30dg6oj 310 19 Mycovirus Mycovirus NNP cord-104317-t30dg6oj 310 20 Infection Infection NNP cord-104317-t30dg6oj 310 21 of of IN cord-104317-t30dg6oj 310 22 Aspergillus aspergillus NN cord-104317-t30dg6oj 310 23 fumigatus fumigatus NN cord-104317-t30dg6oj 310 24 Is be VBZ cord-104317-t30dg6oj 310 25 Not not RB cord-104317-t30dg6oj 310 26 Dependent dependent JJ cord-104317-t30dg6oj 310 27 on on IN cord-104317-t30dg6oj 310 28 the the DT cord-104317-t30dg6oj 310 29 Genetic genetic JJ cord-104317-t30dg6oj 310 30 Make make NN cord-104317-t30dg6oj 310 31 - - HYPH cord-104317-t30dg6oj 310 32 Up up NN cord-104317-t30dg6oj 310 33 of of IN cord-104317-t30dg6oj 310 34 the the DT cord-104317-t30dg6oj 310 35 Host Host NNP cord-104317-t30dg6oj 310 36 A A NNP cord-104317-t30dg6oj 310 37 novel novel JJ cord-104317-t30dg6oj 310 38 mycovirus mycovirus NN cord-104317-t30dg6oj 310 39 from from IN cord-104317-t30dg6oj 310 40 Aspergillus Aspergillus NNP cord-104317-t30dg6oj 310 41 fumigatus fumigatus NN cord-104317-t30dg6oj 311 1 contains contain VBZ cord-104317-t30dg6oj 311 2 four four CD cord-104317-t30dg6oj 311 3 unique unique JJ cord-104317-t30dg6oj 311 4 dsRNAs dsRNAs NNPS cord-104317-t30dg6oj 311 5 as as IN cord-104317-t30dg6oj 311 6 its -PRON- PRP$ cord-104317-t30dg6oj 311 7 genome genome NN cord-104317-t30dg6oj 311 8 and and CC cord-104317-t30dg6oj 311 9 is be VBZ cord-104317-t30dg6oj 311 10 infectious infectious JJ cord-104317-t30dg6oj 311 11 as as IN cord-104317-t30dg6oj 311 12 dsRNA dsrna NN cord-104317-t30dg6oj 312 1 Viruses virus NNS cord-104317-t30dg6oj 312 2 of of IN cord-104317-t30dg6oj 312 3 parasitic parasitic JJ cord-104317-t30dg6oj 312 4 protozoa protozoan NNS cord-104317-t30dg6oj 312 5 . . . cord-104317-t30dg6oj 313 1 Parasitol Parasitol NNP cord-104317-t30dg6oj 314 1 Today today NN cord-104317-t30dg6oj 314 2 Nibert Nibert NNP cord-104317-t30dg6oj 314 3 ML ML NNP cord-104317-t30dg6oj 314 4 . . . cord-104317-t30dg6oj 315 1 Structure structure NN cord-104317-t30dg6oj 315 2 of of IN cord-104317-t30dg6oj 315 3 a a DT cord-104317-t30dg6oj 315 4 Protozoan Protozoan NNP cord-104317-t30dg6oj 315 5 Virus virus NN cord-104317-t30dg6oj 315 6 from from IN cord-104317-t30dg6oj 315 7 the the DT cord-104317-t30dg6oj 315 8 Human Human NNP cord-104317-t30dg6oj 315 9 Genitourinary Genitourinary NNP cord-104317-t30dg6oj 315 10 Parasite Parasite NNP cord-104317-t30dg6oj 315 11 Trichomonas Trichomonas NNP cord-104317-t30dg6oj 315 12 vaginalis vaginalis NN cord-104317-t30dg6oj 315 13 RNA RNA NNP cord-104317-t30dg6oj 315 14 Viral Viral NNP cord-104317-t30dg6oj 315 15 Community Community NNP cord-104317-t30dg6oj 315 16 in in IN cord-104317-t30dg6oj 315 17 Human Human NNP cord-104317-t30dg6oj 315 18 Feces fece NNS cord-104317-t30dg6oj 315 19 : : : cord-104317-t30dg6oj 315 20 Prevalence prevalence NN cord-104317-t30dg6oj 315 21 of of IN cord-104317-t30dg6oj 315 22 Plant Plant NNP cord-104317-t30dg6oj 315 23 Pathogenic Pathogenic NNP cord-104317-t30dg6oj 315 24 Viruses Viruses NNPS cord-104317-t30dg6oj 315 25 Expression expression NN cord-104317-t30dg6oj 315 26 of of IN cord-104317-t30dg6oj 315 27 tobacco tobacco NN cord-104317-t30dg6oj 315 28 mosaic mosaic NNP cord-104317-t30dg6oj 315 29 virus virus NN cord-104317-t30dg6oj 315 30 coat coat NN cord-104317-t30dg6oj 315 31 protein protein NN cord-104317-t30dg6oj 315 32 and and CC cord-104317-t30dg6oj 315 33 assembly assembly NN cord-104317-t30dg6oj 315 34 of of IN cord-104317-t30dg6oj 315 35 pseudovirus pseudovirus NNP cord-104317-t30dg6oj 315 36 particles particle NNS cord-104317-t30dg6oj 315 37 in in IN cord-104317-t30dg6oj 315 38 Escherichia Escherichia NNP cord-104317-t30dg6oj 315 39 coli coli VBZ cord-104317-t30dg6oj 315 40 Predominance predominance NN cord-104317-t30dg6oj 315 41 of of IN cord-104317-t30dg6oj 315 42 rhinovirus rhinovirus NN cord-104317-t30dg6oj 315 43 in in IN cord-104317-t30dg6oj 315 44 the the DT cord-104317-t30dg6oj 315 45 nose nose NN cord-104317-t30dg6oj 315 46 of of IN cord-104317-t30dg6oj 315 47 symptomatic symptomatic JJ cord-104317-t30dg6oj 315 48 and and CC cord-104317-t30dg6oj 315 49 asymptomatic asymptomatic JJ cord-104317-t30dg6oj 315 50 infants infant NNS cord-104317-t30dg6oj 315 51 Identification identification NN cord-104317-t30dg6oj 315 52 of of IN cord-104317-t30dg6oj 315 53 Respiratory respiratory JJ cord-104317-t30dg6oj 315 54 Viruses virus NNS cord-104317-t30dg6oj 315 55 in in IN cord-104317-t30dg6oj 315 56 Asymptomatic asymptomatic JJ cord-104317-t30dg6oj 315 57 Subjects subject NNS cord-104317-t30dg6oj 315 58 : : : cord-104317-t30dg6oj 315 59 Asymptomatic asymptomatic JJ cord-104317-t30dg6oj 315 60 Respiratory respiratory JJ cord-104317-t30dg6oj 315 61 Viral Viral NNP cord-104317-t30dg6oj 315 62 Infections Infections NNPS cord-104317-t30dg6oj 315 63 Human Human NNP cord-104317-t30dg6oj 315 64 Rhinoviruses Rhinoviruses NNP cord-104317-t30dg6oj 315 65 Viral Viral NNP cord-104317-t30dg6oj 315 66 and and CC cord-104317-t30dg6oj 315 67 Bacterial bacterial JJ cord-104317-t30dg6oj 315 68 Interactions Interactions NNPS cord-104317-t30dg6oj 315 69 in in IN cord-104317-t30dg6oj 315 70 the the DT cord-104317-t30dg6oj 315 71 Upper Upper NNP cord-104317-t30dg6oj 315 72 Respiratory Respiratory NNP cord-104317-t30dg6oj 315 73 Tract tract NN cord-104317-t30dg6oj 316 1 The the DT cord-104317-t30dg6oj 316 2 Ubiquity Ubiquity NNP cord-104317-t30dg6oj 316 3 and and CC cord-104317-t30dg6oj 316 4 Impressive Impressive NNP cord-104317-t30dg6oj 316 5 Genomic Genomic NNP cord-104317-t30dg6oj 316 6 Diversity Diversity NNP cord-104317-t30dg6oj 316 7 of of IN cord-104317-t30dg6oj 316 8 Human human JJ cord-104317-t30dg6oj 316 9 Skin skin NN cord-104317-t30dg6oj 316 10 Papillomaviruses Papillomaviruses NNPS cord-104317-t30dg6oj 316 11 Suggest suggest VBP cord-104317-t30dg6oj 316 12 a a DT cord-104317-t30dg6oj 316 13 Commensalic Commensalic NNP cord-104317-t30dg6oj 316 14 Nature nature NN cord-104317-t30dg6oj 316 15 of of IN cord-104317-t30dg6oj 316 16 These these DT cord-104317-t30dg6oj 316 17 Viruses virus NNS cord-104317-t30dg6oj 317 1 A a DT cord-104317-t30dg6oj 317 2 Novel Novel NNP cord-104317-t30dg6oj 317 3 DNA dna NN cord-104317-t30dg6oj 317 4 Virus virus NN cord-104317-t30dg6oj 317 5 ( ( -LRB- cord-104317-t30dg6oj 317 6 TTV TTV NNP cord-104317-t30dg6oj 317 7 ) ) -RRB- cord-104317-t30dg6oj 318 1 Associated associate VBN cord-104317-t30dg6oj 318 2 with with IN cord-104317-t30dg6oj 318 3 Elevated elevated JJ cord-104317-t30dg6oj 318 4 Transaminase Transaminase NNP cord-104317-t30dg6oj 318 5 Levels Levels NNPS cord-104317-t30dg6oj 318 6 in in IN cord-104317-t30dg6oj 318 7 Posttransfusion Posttransfusion NNP cord-104317-t30dg6oj 318 8 Hepatitis Hepatitis NNP cord-104317-t30dg6oj 318 9 of of IN cord-104317-t30dg6oj 318 10 Unknown Unknown NNP cord-104317-t30dg6oj 318 11 Etiology Etiology NNP cord-104317-t30dg6oj 318 12 Identification identification NN cord-104317-t30dg6oj 318 13 of of IN cord-104317-t30dg6oj 318 14 a a DT cord-104317-t30dg6oj 318 15 new new JJ cord-104317-t30dg6oj 318 16 human human JJ cord-104317-t30dg6oj 318 17 DNA dna NN cord-104317-t30dg6oj 318 18 virus virus NN cord-104317-t30dg6oj 318 19 ( ( -LRB- cord-104317-t30dg6oj 318 20 TTV TTV NNP cord-104317-t30dg6oj 318 21 - - HYPH cord-104317-t30dg6oj 318 22 like like JJ cord-104317-t30dg6oj 318 23 mini mini JJ cord-104317-t30dg6oj 318 24 virus virus NN cord-104317-t30dg6oj 318 25 , , , cord-104317-t30dg6oj 318 26 TLMV TLMV NNP cord-104317-t30dg6oj 318 27 ) ) -RRB- cord-104317-t30dg6oj 318 28 intermediately intermediately RB cord-104317-t30dg6oj 318 29 related relate VBD cord-104317-t30dg6oj 318 30 to to IN cord-104317-t30dg6oj 318 31 TT TT NNP cord-104317-t30dg6oj 318 32 virus virus NN cord-104317-t30dg6oj 318 33 and and CC cord-104317-t30dg6oj 318 34 chicken chicken NN cord-104317-t30dg6oj 318 35 anemia anemia NN cord-104317-t30dg6oj 318 36 virus virus NN cord-104317-t30dg6oj 318 37 New new JJ cord-104317-t30dg6oj 318 38 DNA dna NN cord-104317-t30dg6oj 318 39 Viruses virus NNS cord-104317-t30dg6oj 318 40 Identified identify VBN cord-104317-t30dg6oj 318 41 in in IN cord-104317-t30dg6oj 318 42 Patients patient NNS cord-104317-t30dg6oj 318 43 with with IN cord-104317-t30dg6oj 318 44 Acute acute JJ cord-104317-t30dg6oj 318 45 Viral Viral NNP cord-104317-t30dg6oj 318 46 Infection Infection NNP cord-104317-t30dg6oj 318 47 Syndrome Syndrome NNP cord-104317-t30dg6oj 318 48 Identification Identification NNP cord-104317-t30dg6oj 318 49 and and CC cord-104317-t30dg6oj 318 50 genomic genomic JJ cord-104317-t30dg6oj 318 51 characterization characterization NN cord-104317-t30dg6oj 318 52 of of IN cord-104317-t30dg6oj 318 53 a a DT cord-104317-t30dg6oj 318 54 novel novel JJ cord-104317-t30dg6oj 318 55 human human NN cord-104317-t30dg6oj 318 56 torque torque NN cord-104317-t30dg6oj 318 57 teno teno NNP cord-104317-t30dg6oj 318 58 virus virus NN cord-104317-t30dg6oj 318 59 of of IN cord-104317-t30dg6oj 318 60 3.2 3.2 CD cord-104317-t30dg6oj 318 61 kb kb NNP cord-104317-t30dg6oj 318 62 Transfusion Transfusion NNP cord-104317-t30dg6oj 318 63 transmission transmission NN cord-104317-t30dg6oj 318 64 of of IN cord-104317-t30dg6oj 318 65 highly highly RB cord-104317-t30dg6oj 318 66 prevalent prevalent JJ cord-104317-t30dg6oj 318 67 commensal commensal JJ cord-104317-t30dg6oj 318 68 human human NN cord-104317-t30dg6oj 318 69 viruses virus NNS cord-104317-t30dg6oj 318 70 Our -PRON- PRP$ cord-104317-t30dg6oj 318 71 Current current JJ cord-104317-t30dg6oj 318 72 Understanding understanding NN cord-104317-t30dg6oj 318 73 of of IN cord-104317-t30dg6oj 318 74 Mutualism Mutualism NNP cord-104317-t30dg6oj 318 75 Transmission Transmission NNP cord-104317-t30dg6oj 318 76 Modes Modes NNPS cord-104317-t30dg6oj 318 77 and and CC cord-104317-t30dg6oj 318 78 Evolution evolution NN cord-104317-t30dg6oj 318 79 of of IN cord-104317-t30dg6oj 318 80 the the DT cord-104317-t30dg6oj 318 81 Parasitism Parasitism NNP cord-104317-t30dg6oj 318 82 - - HYPH cord-104317-t30dg6oj 318 83 Mutualism Mutualism NNP cord-104317-t30dg6oj 318 84 Continuuma Continuuma NNP cord-104317-t30dg6oj 318 85 The the DT cord-104317-t30dg6oj 318 86 Origin Origin NNP cord-104317-t30dg6oj 318 87 of of IN cord-104317-t30dg6oj 318 88 Mitochondria Mitochondria NNP cord-104317-t30dg6oj 318 89 . . . cord-104317-t30dg6oj 319 1 Nat Nat NNP cord-104317-t30dg6oj 319 2 Educ Educ NNP cord-104317-t30dg6oj 319 3 . . . cord-104317-t30dg6oj 320 1 These these DT cord-104317-t30dg6oj 320 2 functional functional JJ cord-104317-t30dg6oj 320 3 types type NNS cord-104317-t30dg6oj 320 4 do do VBP cord-104317-t30dg6oj 320 5 not not RB cord-104317-t30dg6oj 320 6 correspond correspond VB cord-104317-t30dg6oj 320 7 to to IN cord-104317-t30dg6oj 320 8 natural natural JJ cord-104317-t30dg6oj 320 9 groups group NNS cord-104317-t30dg6oj 320 10 , , , cord-104317-t30dg6oj 320 11 because because IN cord-104317-t30dg6oj 320 12 they -PRON- PRP cord-104317-t30dg6oj 320 13 occur occur VBP cord-104317-t30dg6oj 320 14 in in IN cord-104317-t30dg6oj 320 15 an an DT cord-104317-t30dg6oj 320 16 interleaved interleaved JJ cord-104317-t30dg6oj 320 17 manner manner NN cord-104317-t30dg6oj 320 18 across across IN cord-104317-t30dg6oj 320 19 the the DT cord-104317-t30dg6oj 320 20 tree tree NN cord-104317-t30dg6oj 320 21 of of IN cord-104317-t30dg6oj 320 22 eukaryotic eukaryotic JJ cord-104317-t30dg6oj 320 23 life life NN cord-104317-t30dg6oj 320 24 . . . cord-104317-t30dg6oj 321 1 Instead instead RB cord-104317-t30dg6oj 321 2 they -PRON- PRP cord-104317-t30dg6oj 321 3 correspond correspond VBP cord-104317-t30dg6oj 321 4 to to IN cord-104317-t30dg6oj 321 5 ecological ecological JJ cord-104317-t30dg6oj 321 6 specializations specialization NNS cord-104317-t30dg6oj 321 7 Mitochondrial Mitochondrial NNP cord-104317-t30dg6oj 321 8 Evolution Evolution NNP cord-104317-t30dg6oj 321 9 . . . cord-104317-t30dg6oj 322 1 Cold Cold NNP cord-104317-t30dg6oj 322 2 Spring Spring NNP cord-104317-t30dg6oj 322 3 Harb Harb NNP cord-104317-t30dg6oj 322 4 Perspect Perspect NNP cord-104317-t30dg6oj 323 1 A a DT cord-104317-t30dg6oj 323 2 unified unified JJ cord-104317-t30dg6oj 323 3 initiative initiative NN cord-104317-t30dg6oj 323 4 to to TO cord-104317-t30dg6oj 323 5 harness harness VB cord-104317-t30dg6oj 323 6 Earth Earth NNP cord-104317-t30dg6oj 323 7 's 's POS cord-104317-t30dg6oj 323 8 microbiomes microbiome NNS cord-104317-t30dg6oj 324 1 The the DT cord-104317-t30dg6oj 324 2 microbiome microbiome NN cord-104317-t30dg6oj 324 3 revolution revolution NN cord-104317-t30dg6oj 324 4 Taking take VBG cord-104317-t30dg6oj 324 5 it -PRON- PRP cord-104317-t30dg6oj 324 6 Personally personally RB cord-104317-t30dg6oj 325 1 : : : cord-104317-t30dg6oj 325 2 Personalized personalized JJ cord-104317-t30dg6oj 325 3 Utilization utilization NN cord-104317-t30dg6oj 325 4 of of IN cord-104317-t30dg6oj 325 5 the the DT cord-104317-t30dg6oj 325 6 Human Human NNP cord-104317-t30dg6oj 325 7 Microbiome Microbiome NNP cord-104317-t30dg6oj 325 8 in in IN cord-104317-t30dg6oj 325 9 Health Health NNP cord-104317-t30dg6oj 325 10 and and CC cord-104317-t30dg6oj 325 11 Disease Disease NNP cord-104317-t30dg6oj 325 12 Immunity Immunity NNP cord-104317-t30dg6oj 325 13 and and CC cord-104317-t30dg6oj 325 14 symbiosis symbiosis NN cord-104317-t30dg6oj 325 15 Bacterial bacterial JJ cord-104317-t30dg6oj 325 16 symbionts symbiont NNS cord-104317-t30dg6oj 325 17 as as IN cord-104317-t30dg6oj 325 18 mediators mediator NNS cord-104317-t30dg6oj 325 19 of of IN cord-104317-t30dg6oj 325 20 ecologically ecologically RB cord-104317-t30dg6oj 325 21 important important JJ cord-104317-t30dg6oj 325 22 traits trait NNS cord-104317-t30dg6oj 325 23 of of IN cord-104317-t30dg6oj 325 24 insect insect NN cord-104317-t30dg6oj 325 25 hosts host NNS cord-104317-t30dg6oj 325 26 The the DT cord-104317-t30dg6oj 325 27 mouse mouse NN cord-104317-t30dg6oj 325 28 " " `` cord-104317-t30dg6oj 325 29 xenotropic xenotropic NNP cord-104317-t30dg6oj 325 30 " " '' cord-104317-t30dg6oj 325 31 gammaretroviruses gammaretroviruse NNS cord-104317-t30dg6oj 325 32 and and CC cord-104317-t30dg6oj 325 33 their -PRON- PRP$ cord-104317-t30dg6oj 325 34 XPR1 XPR1 NNP cord-104317-t30dg6oj 325 35 receptor receptor NN cord-104317-t30dg6oj 325 36 Studies study NNS cord-104317-t30dg6oj 325 37 of of IN cord-104317-t30dg6oj 325 38 endogenous endogenous JJ cord-104317-t30dg6oj 325 39 retroviruses retrovirus NNS cord-104317-t30dg6oj 325 40 reveal reveal VBP cord-104317-t30dg6oj 325 41 a a DT cord-104317-t30dg6oj 325 42 continuing continue VBG cord-104317-t30dg6oj 325 43 evolutionary evolutionary JJ cord-104317-t30dg6oj 325 44 saga saga NN cord-104317-t30dg6oj 325 45 Evidence evidence NN cord-104317-t30dg6oj 325 46 for for IN cord-104317-t30dg6oj 325 47 genomic genomic JJ cord-104317-t30dg6oj 325 48 rearrangements rearrangement NNS cord-104317-t30dg6oj 325 49 mediated mediate VBN cord-104317-t30dg6oj 325 50 by by IN cord-104317-t30dg6oj 325 51 human human JJ cord-104317-t30dg6oj 325 52 endogenous endogenous JJ cord-104317-t30dg6oj 325 53 retroviruses retrovirus NNS cord-104317-t30dg6oj 325 54 during during IN cord-104317-t30dg6oj 325 55 primate primate JJ cord-104317-t30dg6oj 325 56 evolution evolution NN cord-104317-t30dg6oj 325 57 Retroelements Retroelements NNP cord-104317-t30dg6oj 325 58 and and CC cord-104317-t30dg6oj 325 59 their -PRON- PRP$ cord-104317-t30dg6oj 325 60 impact impact NN cord-104317-t30dg6oj 325 61 on on IN cord-104317-t30dg6oj 325 62 genome genome NN cord-104317-t30dg6oj 325 63 evolution evolution NN cord-104317-t30dg6oj 325 64 and and CC cord-104317-t30dg6oj 325 65 functioning function VBG cord-104317-t30dg6oj 325 66 Retroelements Retroelements NNP cord-104317-t30dg6oj 325 67 and and CC cord-104317-t30dg6oj 325 68 the the DT cord-104317-t30dg6oj 325 69 human human JJ cord-104317-t30dg6oj 325 70 genome genome NN cord-104317-t30dg6oj 325 71 : : : cord-104317-t30dg6oj 326 1 New new JJ cord-104317-t30dg6oj 326 2 perspectives perspective NNS cord-104317-t30dg6oj 326 3 on on IN cord-104317-t30dg6oj 326 4 an an DT cord-104317-t30dg6oj 326 5 old old JJ cord-104317-t30dg6oj 326 6 relation relation NN cord-104317-t30dg6oj 326 7 Endogenous endogenous JJ cord-104317-t30dg6oj 326 8 retroviral retroviral NN cord-104317-t30dg6oj 326 9 sequences sequence NNS cord-104317-t30dg6oj 326 10 are be VBP cord-104317-t30dg6oj 326 11 required require VBN cord-104317-t30dg6oj 326 12 for for IN cord-104317-t30dg6oj 326 13 tissue tissue NN cord-104317-t30dg6oj 326 14 - - HYPH cord-104317-t30dg6oj 326 15 specific specific JJ cord-104317-t30dg6oj 326 16 expression expression NN cord-104317-t30dg6oj 326 17 of of IN cord-104317-t30dg6oj 326 18 a a DT cord-104317-t30dg6oj 326 19 human human JJ cord-104317-t30dg6oj 326 20 salivary salivary NN cord-104317-t30dg6oj 326 21 amylase amylase NN cord-104317-t30dg6oj 326 22 gene gene NN cord-104317-t30dg6oj 326 23 HERV HERV NNP cord-104317-t30dg6oj 326 24 - - HYPH cord-104317-t30dg6oj 326 25 H H NNP cord-104317-t30dg6oj 326 26 RNA RNA NNP cord-104317-t30dg6oj 326 27 is be VBZ cord-104317-t30dg6oj 326 28 abundant abundant JJ cord-104317-t30dg6oj 326 29 in in IN cord-104317-t30dg6oj 326 30 human human JJ cord-104317-t30dg6oj 326 31 embryonic embryonic JJ cord-104317-t30dg6oj 326 32 stem stem NN cord-104317-t30dg6oj 326 33 cells cell NNS cord-104317-t30dg6oj 326 34 and and CC cord-104317-t30dg6oj 326 35 a a DT cord-104317-t30dg6oj 326 36 precise precise JJ cord-104317-t30dg6oj 326 37 marker marker NN cord-104317-t30dg6oj 326 38 for for IN cord-104317-t30dg6oj 326 39 pluripotency pluripotency NN cord-104317-t30dg6oj 326 40 Microarray Microarray NNP cord-104317-t30dg6oj 326 41 analysis analysis NN cord-104317-t30dg6oj 326 42 reveals reveal VBZ cord-104317-t30dg6oj 326 43 global global JJ cord-104317-t30dg6oj 326 44 modulation modulation NN cord-104317-t30dg6oj 326 45 of of IN cord-104317-t30dg6oj 326 46 endogenous endogenous JJ cord-104317-t30dg6oj 326 47 retroelement retroelement NN cord-104317-t30dg6oj 326 48 transcription transcription NN cord-104317-t30dg6oj 326 49 by by IN cord-104317-t30dg6oj 326 50 microbes microbe NNS cord-104317-t30dg6oj 326 51 MAVS MAVS NNP cord-104317-t30dg6oj 326 52 , , , cord-104317-t30dg6oj 326 53 cGAS cgas NN cord-104317-t30dg6oj 326 54 , , , cord-104317-t30dg6oj 326 55 and and CC cord-104317-t30dg6oj 326 56 endogenous endogenous JJ cord-104317-t30dg6oj 326 57 retroviruses retrovirus NNS cord-104317-t30dg6oj 326 58 in in IN cord-104317-t30dg6oj 326 59 T T NNP cord-104317-t30dg6oj 326 60 - - HYPH cord-104317-t30dg6oj 326 61 independent independent JJ cord-104317-t30dg6oj 326 62 B B NNP cord-104317-t30dg6oj 326 63 cell cell NN cord-104317-t30dg6oj 326 64 responses response NNS cord-104317-t30dg6oj 326 65 Interactions interaction NNS cord-104317-t30dg6oj 326 66 between between IN cord-104317-t30dg6oj 326 67 exogenous exogenous JJ cord-104317-t30dg6oj 326 68 and and CC cord-104317-t30dg6oj 326 69 endogenous endogenous JJ cord-104317-t30dg6oj 326 70 retroviruses retrovirus NNS cord-104317-t30dg6oj 327 1 Positional positional JJ cord-104317-t30dg6oj 327 2 cloning cloning NN cord-104317-t30dg6oj 327 3 of of IN cord-104317-t30dg6oj 327 4 the the DT cord-104317-t30dg6oj 327 5 mouse mouse NN cord-104317-t30dg6oj 327 6 retrovirus retrovirus NN cord-104317-t30dg6oj 327 7 restriction restriction NN cord-104317-t30dg6oj 327 8 gene gene NN cord-104317-t30dg6oj 327 9 Fv1 Fv1 NNP cord-104317-t30dg6oj 327 10 Rmcf2 Rmcf2 NNP cord-104317-t30dg6oj 327 11 , , , cord-104317-t30dg6oj 327 12 a a DT cord-104317-t30dg6oj 327 13 xenotropic xenotropic NNP cord-104317-t30dg6oj 327 14 provirus provirus NN cord-104317-t30dg6oj 327 15 in in IN cord-104317-t30dg6oj 327 16 the the DT cord-104317-t30dg6oj 327 17 Asian asian JJ cord-104317-t30dg6oj 327 18 mouse mouse NN cord-104317-t30dg6oj 327 19 species specie NNS cord-104317-t30dg6oj 327 20 Mus Mus NNP cord-104317-t30dg6oj 327 21 castaneus castaneu NNS cord-104317-t30dg6oj 327 22 , , , cord-104317-t30dg6oj 327 23 blocks block VBZ cord-104317-t30dg6oj 327 24 infection infection NN cord-104317-t30dg6oj 327 25 by by IN cord-104317-t30dg6oj 327 26 polytropic polytropic NNP cord-104317-t30dg6oj 327 27 mouse mouse NN cord-104317-t30dg6oj 327 28 gammaretroviruses gammaretroviruse NNS cord-104317-t30dg6oj 327 29 From from IN cord-104317-t30dg6oj 327 30 ancestral ancestral JJ cord-104317-t30dg6oj 327 31 infectious infectious JJ cord-104317-t30dg6oj 327 32 retroviruses retrovirus NNS cord-104317-t30dg6oj 327 33 to to IN cord-104317-t30dg6oj 327 34 bona bona FW cord-104317-t30dg6oj 327 35 fide fide JJ cord-104317-t30dg6oj 327 36 cellular cellular JJ cord-104317-t30dg6oj 327 37 genes gene NNS cord-104317-t30dg6oj 327 38 : : : cord-104317-t30dg6oj 327 39 Role role NN cord-104317-t30dg6oj 327 40 of of IN cord-104317-t30dg6oj 327 41 the the DT cord-104317-t30dg6oj 327 42 captured capture VBN cord-104317-t30dg6oj 327 43 syncytins syncytin NNS cord-104317-t30dg6oj 327 44 in in IN cord-104317-t30dg6oj 327 45 placentation placentation NN cord-104317-t30dg6oj 327 46 Retroviruses retrovirus NNS cord-104317-t30dg6oj 327 47 and and CC cord-104317-t30dg6oj 327 48 the the DT cord-104317-t30dg6oj 327 49 Placenta Placenta NNP cord-104317-t30dg6oj 327 50 Retroviral Retroviral NNP cord-104317-t30dg6oj 327 51 gene gene NN cord-104317-t30dg6oj 327 52 therapy therapy NN cord-104317-t30dg6oj 327 53 : : : cord-104317-t30dg6oj 327 54 safety safety NN cord-104317-t30dg6oj 327 55 issues issue NNS cord-104317-t30dg6oj 327 56 and and CC cord-104317-t30dg6oj 327 57 possible possible JJ cord-104317-t30dg6oj 327 58 solutions solution NNS cord-104317-t30dg6oj 327 59 Decade decade NN cord-104317-t30dg6oj 327 60 - - HYPH cord-104317-t30dg6oj 327 61 Long Long NNP cord-104317-t30dg6oj 327 62 Safety Safety NNP cord-104317-t30dg6oj 327 63 and and CC cord-104317-t30dg6oj 327 64 Function Function NNP cord-104317-t30dg6oj 327 65 of of IN cord-104317-t30dg6oj 327 66 Retroviral Retroviral NNP cord-104317-t30dg6oj 327 67 - - HYPH cord-104317-t30dg6oj 327 68 Modified modify VBN cord-104317-t30dg6oj 327 69 Chimeric Chimeric NNP cord-104317-t30dg6oj 327 70 Antigen Antigen NNP cord-104317-t30dg6oj 327 71 Receptor Receptor NNP cord-104317-t30dg6oj 327 72 T T NNP cord-104317-t30dg6oj 327 73 Cells cell NNS cord-104317-t30dg6oj 327 74 Bacteriophage Bacteriophage NNP cord-104317-t30dg6oj 327 75 adhering adhere VBG cord-104317-t30dg6oj 327 76 to to IN cord-104317-t30dg6oj 327 77 mucus mucus NN cord-104317-t30dg6oj 327 78 provide provide VB cord-104317-t30dg6oj 327 79 a a DT cord-104317-t30dg6oj 327 80 non non JJ cord-104317-t30dg6oj 327 81 - - JJ cord-104317-t30dg6oj 327 82 host host JJ cord-104317-t30dg6oj 327 83 - - HYPH cord-104317-t30dg6oj 327 84 derived derive VBN cord-104317-t30dg6oj 327 85 immunity immunity NN cord-104317-t30dg6oj 327 86 Reinventing reinvent VBG cord-104317-t30dg6oj 327 87 phage phage NN cord-104317-t30dg6oj 327 88 therapy therapy NN cord-104317-t30dg6oj 327 89 : : : cord-104317-t30dg6oj 327 90 are be VBP cord-104317-t30dg6oj 327 91 the the DT cord-104317-t30dg6oj 327 92 parts part NNS cord-104317-t30dg6oj 327 93 greater great JJR cord-104317-t30dg6oj 327 94 than than IN cord-104317-t30dg6oj 327 95 the the DT cord-104317-t30dg6oj 327 96 sum sum NN cord-104317-t30dg6oj 327 97 ? ? . cord-104317-t30dg6oj 328 1 The the DT cord-104317-t30dg6oj 328 2 next next JJ cord-104317-t30dg6oj 328 3 generation generation NN cord-104317-t30dg6oj 328 4 of of IN cord-104317-t30dg6oj 328 5 bacteriophage bacteriophage NN cord-104317-t30dg6oj 328 6 therapy therapy NN cord-104317-t30dg6oj 328 7 Going go VBG cord-104317-t30dg6oj 328 8 viral viral JJ cord-104317-t30dg6oj 329 1 : : : cord-104317-t30dg6oj 329 2 next next JJ cord-104317-t30dg6oj 329 3 - - HYPH cord-104317-t30dg6oj 329 4 generation generation NN cord-104317-t30dg6oj 329 5 sequencing sequencing NN cord-104317-t30dg6oj 329 6 applied apply VBN cord-104317-t30dg6oj 329 7 to to IN cord-104317-t30dg6oj 329 8 phage phage NN cord-104317-t30dg6oj 329 9 populations population NNS cord-104317-t30dg6oj 329 10 in in IN cord-104317-t30dg6oj 329 11 the the DT cord-104317-t30dg6oj 329 12 human human JJ cord-104317-t30dg6oj 329 13 gut gut NN cord-104317-t30dg6oj 329 14 GB GB NNP cord-104317-t30dg6oj 329 15 Virus virus NN cord-104317-t30dg6oj 329 16 C C NNP cord-104317-t30dg6oj 329 17 / / SYM cord-104317-t30dg6oj 329 18 Hepatitis Hepatitis NNP cord-104317-t30dg6oj 329 19 G G NNP cord-104317-t30dg6oj 329 20 Virus virus NN cord-104317-t30dg6oj 329 21 Infection infection NN cord-104317-t30dg6oj 329 22 : : : cord-104317-t30dg6oj 329 23 A a DT cord-104317-t30dg6oj 329 24 Favorable favorable JJ cord-104317-t30dg6oj 329 25 Prognostic prognostic JJ cord-104317-t30dg6oj 329 26 Factor factor NN cord-104317-t30dg6oj 329 27 in in IN cord-104317-t30dg6oj 329 28 Human Human NNP cord-104317-t30dg6oj 329 29 Immunodeficiency Immunodeficiency NNP cord-104317-t30dg6oj 329 30 Virus Virus NNP cord-104317-t30dg6oj 329 31 - - HYPH cord-104317-t30dg6oj 329 32 Infected infect VBN cord-104317-t30dg6oj 329 33 Patients patient NNS cord-104317-t30dg6oj 329 34 ? ? . cord-104317-t30dg6oj 330 1 Infection infection NN cord-104317-t30dg6oj 330 2 with with IN cord-104317-t30dg6oj 330 3 GB GB NNP cord-104317-t30dg6oj 330 4 Virus virus NN cord-104317-t30dg6oj 330 5 C C NNP cord-104317-t30dg6oj 330 6 and and CC cord-104317-t30dg6oj 330 7 Reduced reduce VBN cord-104317-t30dg6oj 330 8 Mortality mortality NN cord-104317-t30dg6oj 330 9 among among IN cord-104317-t30dg6oj 330 10 HIV HIV NNP cord-104317-t30dg6oj 330 11 - - HYPH cord-104317-t30dg6oj 330 12 Infected Infected NNP cord-104317-t30dg6oj 330 13 Patients Patients NNPS cord-104317-t30dg6oj 330 14 Human human JJ cord-104317-t30dg6oj 330 15 cytomegalovirus cytomegalovirus NN cord-104317-t30dg6oj 330 16 modulation modulation NN cord-104317-t30dg6oj 330 17 of of IN cord-104317-t30dg6oj 330 18 CCR5 ccr5 JJ cord-104317-t30dg6oj 330 19 expression expression NN cord-104317-t30dg6oj 330 20 on on IN cord-104317-t30dg6oj 330 21 myeloid myeloid JJ cord-104317-t30dg6oj 330 22 cells cell NNS cord-104317-t30dg6oj 330 23 affects affect VBZ cord-104317-t30dg6oj 330 24 susceptibility susceptibility NN cord-104317-t30dg6oj 330 25 to to IN cord-104317-t30dg6oj 330 26 human human JJ cord-104317-t30dg6oj 330 27 immunodeficiency immunodeficiency NN cord-104317-t30dg6oj 330 28 virus virus NN cord-104317-t30dg6oj 330 29 type type NN cord-104317-t30dg6oj 330 30 1 1 CD cord-104317-t30dg6oj 330 31 infection infection NN cord-104317-t30dg6oj 331 1 Hepatitis Hepatitis NNP cord-104317-t30dg6oj 331 2 A a DT cord-104317-t30dg6oj 331 3 virus virus NN cord-104317-t30dg6oj 331 4 infection infection NN cord-104317-t30dg6oj 331 5 suppresses suppress VBZ cord-104317-t30dg6oj 331 6 hepatitis hepatitis NN cord-104317-t30dg6oj 331 7 C c NN cord-104317-t30dg6oj 331 8 virus virus NN cord-104317-t30dg6oj 331 9 replication replication NN cord-104317-t30dg6oj 331 10 and and CC cord-104317-t30dg6oj 331 11 may may MD cord-104317-t30dg6oj 331 12 lead lead VB cord-104317-t30dg6oj 331 13 to to IN cord-104317-t30dg6oj 331 14 clearance clearance NN cord-104317-t30dg6oj 331 15 of of IN cord-104317-t30dg6oj 331 16 HCV HCV NNP cord-104317-t30dg6oj 331 17 Herpesvirus Herpesvirus NNP cord-104317-t30dg6oj 331 18 latency latency NN cord-104317-t30dg6oj 331 19 confers confer VBZ cord-104317-t30dg6oj 331 20 symbiotic symbiotic JJ cord-104317-t30dg6oj 331 21 protection protection NN cord-104317-t30dg6oj 331 22 from from IN cord-104317-t30dg6oj 331 23 bacterial bacterial JJ cord-104317-t30dg6oj 331 24 infection infection NN cord-104317-t30dg6oj 331 25 Prevention Prevention NNP cord-104317-t30dg6oj 331 26 of of IN cord-104317-t30dg6oj 331 27 type type NN cord-104317-t30dg6oj 331 28 I -PRON- PRP cord-104317-t30dg6oj 331 29 diabetes diabete VBZ cord-104317-t30dg6oj 331 30 in in IN cord-104317-t30dg6oj 331 31 nonobese nonobese JJ cord-104317-t30dg6oj 331 32 diabetic diabetic JJ cord-104317-t30dg6oj 331 33 mice mouse NNS cord-104317-t30dg6oj 331 34 by by IN cord-104317-t30dg6oj 331 35 virus virus NN cord-104317-t30dg6oj 331 36 infection infection NN cord-104317-t30dg6oj 332 1 Recent recent JJ cord-104317-t30dg6oj 332 2 progress progress NN cord-104317-t30dg6oj 332 3 in in IN cord-104317-t30dg6oj 332 4 the the DT cord-104317-t30dg6oj 332 5 battle battle NN cord-104317-t30dg6oj 332 6 between between IN cord-104317-t30dg6oj 332 7 oncolytic oncolytic JJ cord-104317-t30dg6oj 332 8 viruses virus NNS cord-104317-t30dg6oj 332 9 and and CC cord-104317-t30dg6oj 332 10 tumours tumour NNS cord-104317-t30dg6oj 333 1 Gene gene NN cord-104317-t30dg6oj 333 2 therapy therapy NN cord-104317-t30dg6oj 333 3 progress progress NN cord-104317-t30dg6oj 333 4 and and CC cord-104317-t30dg6oj 333 5 prospects prospect NNS cord-104317-t30dg6oj 333 6 cancer cancer NN cord-104317-t30dg6oj 333 7 : : : cord-104317-t30dg6oj 333 8 oncolytic oncolytic NN cord-104317-t30dg6oj 333 9 viruses virus NNS cord-104317-t30dg6oj 333 10 Apoptin Apoptin NNP cord-104317-t30dg6oj 333 11 , , , cord-104317-t30dg6oj 333 12 a a DT cord-104317-t30dg6oj 333 13 tumor tumor NN cord-104317-t30dg6oj 333 14 - - HYPH cord-104317-t30dg6oj 333 15 selective selective JJ cord-104317-t30dg6oj 333 16 killer killer NN cord-104317-t30dg6oj 334 1 An an DT cord-104317-t30dg6oj 334 2 enteric enteric JJ cord-104317-t30dg6oj 334 3 virus virus NN cord-104317-t30dg6oj 334 4 can can MD cord-104317-t30dg6oj 334 5 replace replace VB cord-104317-t30dg6oj 334 6 the the DT cord-104317-t30dg6oj 334 7 beneficial beneficial JJ cord-104317-t30dg6oj 334 8 function function NN cord-104317-t30dg6oj 334 9 of of IN cord-104317-t30dg6oj 334 10 commensal commensal JJ cord-104317-t30dg6oj 334 11 bacteria bacteria NNS cord-104317-t30dg6oj 335 1 Any any DT cord-104317-t30dg6oj 335 2 opinion opinion NN cord-104317-t30dg6oj 335 3 , , , cord-104317-t30dg6oj 335 4 findings finding NNS cord-104317-t30dg6oj 335 5 , , , cord-104317-t30dg6oj 335 6 and and CC cord-104317-t30dg6oj 335 7 conclusions conclusion NNS cord-104317-t30dg6oj 335 8 or or CC cord-104317-t30dg6oj 335 9 recommendations recommendation NNS cord-104317-t30dg6oj 335 10 expressed express VBN cord-104317-t30dg6oj 335 11 in in IN cord-104317-t30dg6oj 335 12 this this DT cord-104317-t30dg6oj 335 13 material material NN cord-104317-t30dg6oj 335 14 are be VBP cord-104317-t30dg6oj 335 15 those those DT cord-104317-t30dg6oj 335 16 of of IN cord-104317-t30dg6oj 335 17 the the DT cord-104317-t30dg6oj 335 18 authors author NNS cord-104317-t30dg6oj 335 19 and and CC cord-104317-t30dg6oj 335 20 do do VBP cord-104317-t30dg6oj 335 21 not not RB cord-104317-t30dg6oj 335 22 necessarily necessarily RB cord-104317-t30dg6oj 335 23 reflect reflect VB cord-104317-t30dg6oj 335 24 the the DT cord-104317-t30dg6oj 335 25 views view NNS cord-104317-t30dg6oj 335 26 of of IN cord-104317-t30dg6oj 335 27 the the DT cord-104317-t30dg6oj 335 28 National National NNP cord-104317-t30dg6oj 335 29 Science Science NNP cord-104317-t30dg6oj 335 30 Foundation Foundation NNP cord-104317-t30dg6oj 335 31 . . .