id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-351490-2fx0w30u	Russell, Clark D.	Treatable traits and therapeutic targets: Goals for systems biology in infectious disease	2017-04-27		.txt	text/plain	4149	185	34	A systems medicine approach to infection has the potential to provide new solutions to old problems: to identify host traits that are potentially amenable to therapeutic intervention, and the host immune factors that could be targeted by host-directed therapies. We suggest there are two major goals for systems biology in infection medicine: (1) to identify subgroups of patients that share treatable features; and, (2) to integrate high-throughput data from clinical and in vitro sources in order to predict tractable therapeutic targets with the potential to alter disease trajectories for individual patients. A systems medicine approach to infection has the potential to combine and integrate relevant signals from clinical, genomic, transcriptomic, proteomic and pathogen biology data to draw inferences about disease pathogenesis. A more specific host-directed therapy, recombinant human activated protein C (rhAPC), was licensed for treatment of severe sepsis based on the results of a single clinical trial [20] .	./cache/cord-351490-2fx0w30u.txt	./txt/cord-351490-2fx0w30u.txt