id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-345654-vyz6f3he	Dennehy, John J.	Evolutionary ecology of virus emergence	2016-12-30		.txt	text/plain	11475	701	43	Virus emergence requires overlap between host populations, alterations in virus genetics to permit infection of new hosts, and adaptation to novel hosts such that between‐host transmission is sustainable, all of which are the purview of the fields of ecology and evolution. I argue that, while virus acquisition of the ability to infect new hosts is not difficult, limited evolutionary trajectories to sustained virus between‐host transmission and the combined effects of mutational meltdown, bottlenecking, demographic stochasticity, density dependence, and genetic erosion in ecological sinks limit most emergence events to dead‐end spillover infections. Virus quasispecies may facilitate host range expansion Viruses are among the smallest nucleic acid-based replicating entities and possess characteristics associated with exceptionally fast evolutionary change: small genomes, short generation times, high mutation rates, large population sizes, high levels of genetic diversity, and strong selection pressures.	./cache/cord-345654-vyz6f3he.txt	./txt/cord-345654-vyz6f3he.txt