id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-345157-fhmhpobi	Qi, Dan	Virus infection-induced host mRNA degradation and potential application of live cell imaging	2018-12-12		.txt	text/plain	2619	158	49	Herein, we focus on several possible mechanisms of infection-induced host RNA turnover, which seems to be a common strategy for both prokaryotic and eukaryotic viruses during the very early stage of infection and a potential application of live cell imaging on its visualization. Many viruses also impair the translation of cellular mRNA [1e3], one of the mechanisms during the shift of gene expression from host to virus, a process termed "host shutoff", in order to prevent the production of anti-viral, host protecting proteins [4] . Moreover, Gaglia et al.'s work showed that viral encoded proteins trigger host mRNA degradation by a primary endonucleolytic cleavage causing shutoff of host gene expression and a host exonuclease such as Xrn1, an important 5 0 to 3 0 exonuclease in human cells, were required in subsequent completion of host mRNA turnover [5] .	./cache/cord-345157-fhmhpobi.txt	./txt/cord-345157-fhmhpobi.txt