id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319448-gt6uqfrl	Casadevall, Arturo	The damage-response framework of microbial pathogenesis	2003		.txt	text/plain	5543	256	37	Host-microorganism interactions that result in the clearance and/or control of a microorganism without the development of clinically relevant host damage represent a basis for the development of vaccines and immune-response-based therapies for infectious diseases. However, host-induced cell and/or tissue damage can also produce detrimental outcomes, which can result in disease or death -although certain manifestations of host damage represent the outcome of a successful immune response to MICROBIAL INFECTION. To address this impediment to studies of host-microorganism interactions, we propose a new theoretical approach to understanding microbial pathogenesis, known as the 'damage-response' framework. The central tenets of the 'damage-response' framework -that the outcome of microbial pathogenesis is the result of a host-microorganism interaction, and that the relevant outcome of this interaction is host damage -provide the basis for a new pathogen-classification scheme. The use of host damage to classify the outcome of a host-microorganism interaction acknowledges and accounts for the contribution of the host immune response to microbial pathogenicity and virulence.	./cache/cord-319448-gt6uqfrl.txt	./txt/cord-319448-gt6uqfrl.txt