id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-288231-vg8bwed9	Haagmans, Bart L.	The Application of Genomics to Emerging Zoonotic Viral Diseases	2009-10-26		.txt	text/plain	3406	146	35	Other viruses, such as influenza A viruses and severe acute respiratory syndrome coronavirus (SARS-CoV), may need multiple genetic changes to adapt successfully to humans as a new host species; these changes might include differential receptor usage, enhanced replication, evasion of innate and adaptive host immune defenses, and/or increased efficiency of transmission. New molecular techniques such as high-throughput sequencing, mRNA expression profiling, and array-based single nucleotide polymorphism (SNP) analysis provide ways to rapidly identify emerging pathogens (Nipah virus and SARS-CoV, for example) and to analyze the diversity of their genomes as well as the host responses against them. After introduction of a new influenza A virus from an avian or porcine reservoir into the human species, viral genomics studies are essential to identify critical mutations that enable the circulating virus to spread efficiently, interact with different receptors, and cause disease in the new host.	./cache/cord-288231-vg8bwed9.txt	./txt/cord-288231-vg8bwed9.txt