id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262585-5vjqrnwh	Hraber, Peter	Resources to Discover and Use Short Linear Motifs in Viral Proteins	2019-08-16		.txt	text/plain	5667	327	40	Viral proteins evade host immune function by molecular mimicry, often achieved by short linear motifs (SLiMs) of three to ten consecutive amino acids (AAs). Molecular mimicry varies over a continuum, from one extreme that includes sequence and structural similarity (i.e., orthologs) of entire proteins, to another extreme of chemical similarity at only a few localized sites, as is the case for short linear motifs (SLiMs). Viral SLiMs are potentially useful in synthetic biology, to provide a toolkit for new functions, for example, to modulate immune responses or to complement and interact with newly developed adjuvants in a synergistic manner [9] . Research efforts to develop broad-spectrum antiviral compounds or design broadly cross-protective vaccine immunogens benefit directly from knowledge of gene products, protein functions, and motifs involved with viral immune interference. SLiMs are useful in synthetic biology, where minor edits can alter target specificity, modulate persistence, reprogram interactions with cell-signaling domains, and alter protein function in myriad other ways.	./cache/cord-262585-5vjqrnwh.txt	./txt/cord-262585-5vjqrnwh.txt