id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007735-ejvv2lxv	Bowdish, D. M. E.	Immunomodulatory Properties of Defensins and Cathelicidins	2006		.txt	text/plain	13907	643	41	The expression of certain β-defensins is inducible upon stimulation with bacterial components or pro-inflammatory cytokines and thus these peptides are presumed to be an important component of host defence to infection or inflammation. The difficulties in assessing the role of host defence peptides in vivo are profound, as it is almost impossible to account for synergistic interactions between peptides and other factors, to assess the actual concentrations at the sites of infection and to discriminate the direct antimicrobial activity of peptides from other less direct effects such as enhancement of inflammatory mechanisms (chemotaxis and recruitment of effector cells, enhancement of nonopsonic phagocytosis, etc.). It appears that host defence peptides induce chemotaxis in two ways: first through direct chemotactic activity of PMNs and mononuclear cells mediated through CCR6 and other as yet to be identified receptors and second through inducing chemokine production which would hypothetically increase the numbers of neutrophils and monocytes at sites of infection.	./cache/cord-007735-ejvv2lxv.txt	./txt/cord-007735-ejvv2lxv.txt