id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-003806-ctass7hz	Bull, James J.	Recombinant vector vaccine evolution	2019-07-19		.txt	text/plain	8803	426	45	These models include evolution arising during the process of manufacture, the dynamics of vaccine and revertant growth, plus innate and adaptive immunity elicited during the course of infection. Here we explore how the combination of evolution during the process of vaccine manufacture and during its within-host dynamics following vaccination could affect the immune responses elicited by a recombinant vector vaccine and reduce its efficacy-the specific interaction between evolution and immunity. Again, the problem is complicated by the limited duration of the infection: reduced antigen production due to vaccine evolution depends not only on interference between the two genomes but also on overall growth and the extent to which it affects the level of immunity to vaccine and vector. The evolutionary consequences should be the same for both types of inferiority, reducing the long term generation of antigen levels within the host, but adaptive immunity would be irrelevant to vaccine evolution during manufacturing and during early growth within the host.	./cache/cord-003806-ctass7hz.txt	./txt/cord-003806-ctass7hz.txt