id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000546-0hobwqpe	Bier, Ethan	Deconstructing host-pathogen interactions in Drosophila	2011-10-06		.txt	text/plain	10025	408	39	We then focus on three related topics: (1) genome-wide RNAi screens in Drosophila cell lines infected with pathogens to identify host pathways for defense or that are exploited by pathogens (e.g. bacteria, fungi, viruses); (2) classical genetic and RNAi screens conducted in intact flies to delineate host defense pathways that are active in specific tissues (e.g. the gut) or to identify important virulence factors produced by the pathogen; and (3) analysis of the function of specific pathogen virulence factors in an intact organism. In one screen using adult flies, host defense factors that are required to protect against intestinal infection with the opportunistic broad-host-spectrum pathogen Serratia marcescens were first identified by using a large collection of fly lines in which 13,000 individual RNAi molecules were used to knock down target gene expression throughout the organism (Cronin et al., 2009) .	./cache/cord-000546-0hobwqpe.txt	./txt/cord-000546-0hobwqpe.txt