id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-326554-iphe3rni	Joshi, Amit	In-Silico Proteomic Exploratory Quest: Crafting T-Cell Epitope Vaccine Against Whipple’s Disease	2020-05-18		.txt	text/plain	3216	189	49	This Immuno-Informatics approach leads us in the prediction of two epitopes: VLMVSAFPL and IRYLAALHL interacting with 4 and 6 HLA DRB1 alleles of MHC Class II respectively. Nowadays epitope based vaccines provide better options in search of good treatment strategy for such type of harmful and rare malady, even if the individuals are genetically predisposed as in case of classical Whipple's disease (Trotta et al. Immune Epitope Database (IEDB) analysis Resource tool of population coverage was used to predict population coverage of the putative epitopes that are exhibiting interaction to HLA alleles and based on MHC-II restriction data (Bui et al. PatchDock tool was deployed for interaction between selected structures of epitopes and HLA DRB1 proteins. Still no one has used vaccine based treatments for Whipple's disease, as it is thought to be rare and possess reduced genome but considered one of the harmful pathogen of human ( Raoult et al.	./cache/cord-326554-iphe3rni.txt	./txt/cord-326554-iphe3rni.txt