id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001247-pxzbirqd	Sun, Lu	A new unconventional HLA-A2-restricted epitope from HBV core protein elicits antiviral cytotoxic T lymphocytes	2014-03-22		.txt	text/plain	4630	259	55	Our data therefore provide insights into the structure characteristics of this unconventional epitope binding to MHC-I molecules, as well as epitope specific CTL activity that orchestrate T cell response and immune evasion in HBV infected patients. To identify immune-dominant HBV-specific CTL epitopes, especially epitopes from HBc protein, is therefore necessary for monitoring T cell responses during disease progression, as well as for developing epitope-based therapeutic vaccines against CHB (Inchauspe and Michel, 2007; Gordon et al., 2013; Liu et al., 2013a, b) . To further determine the epitope-specific CTLs, fresh PBMCs from HLA-A2 + AHB patients were stimulated with HBc141-149 peptide and detected by ex vivo IFN-γ ELISPOT assays. In this study, we identified a new HLA-A2-restricted CD8 + T cell epitope HBc141-149 by screening an overlapping 9-mer peptide pool covering HBV core protein.	./cache/cord-001247-pxzbirqd.txt	./txt/cord-001247-pxzbirqd.txt