key: cord-341304-jdvzpvdx authors: Pata, Rama Kanth; Ahmady, Abolfazl; Kiani, Roudabeh title: Human Immunodeficiency Virus: A Dark Cloud With Silver Lining During the COVID-19 Pandemic date: 2020-07-20 journal: Cureus DOI: 10.7759/cureus.9302 sha: doc_id: 341304 cord_uid: jdvzpvdx In December 2019, China reported a cluster of pneumonia patients infected by a new virus from the coronavirus family called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus quickly spread around the world and infected millions of people, and the World Health Organization (WHO) declared coronavirus disease 2019 (COVID-19) a pandemic on March 11, 2020. Although some patients show only mild or even asymptomatic response to this infection, severe disease with rapid progression to acute respiratory distress and multiorgan failure is also commonly seen. In this report, we discuss three cases of HIV patients who survived COVID-19. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a coronavirus with a positivesense single-stranded ribonucleic acid (RNA). It is believed to have originated in bats because of the 96% genomic similarities it has with bat coronaviruses. The high incubation period (2-14 days) in conjunction with the high survivability of this virus and a high reproductive number (R0 ranging from 1.4 to 6.49, with a mean of 3.28 in one study and 2 to 3.5 in another) [1] [2] [3] have caused it to spread quickly throughout the world. On March 11, 2020 , the World Health Organization (WHO) declared the coronavirus disease 2019 (COVID-19) outbreak a global pandemic. The COVID-19 pandemic has expanded rapidly worldwide. The number of cases has skyrocketed as days passed, and mortality has rapidly increased globally. In this report, we present three cases of HIV patients who survived COVID-19. On March 22, 2020, a 67-year-old female with a past medical history of asthma, coronary artery disease (status post-coronary artery bypass graft two years ago), hypertension, hyperlipidemia, and HIV on antiretroviral medications [bictegrav/emtricit/tenofov ala (Biktarvy® 50-200-25 mg tablet, Gilead Sciences, Foster City, CA) and darunavir/cobicistat (Prezcobix® 800 mg-150 mg tablet, Janssen Pharmaceutica, Beerse, Belgium)] was brought in by emergency medical services (EMS) for progressively worsening shortening of breath associated with weakness and two episodes of watery non-bloody diarrhea for one day. She had sought medical attention two days ago at an emergency department where she had been tested for COVID-19 [reverse transcription-polymerase chain reaction (RT-PCR)]. She had been discharged on levofloxacin. She returned to the hospital for worsening of symptoms but denied any new symptoms including fever or cough. The COVID-19 RT-PCR came back positive later. Her chest CT scan showed multifocal patchy consolidations of the bilateral upper and lower lobes, and the electrocardiogram showed normal sinus rhythm with corrected QT interval (QTc) of 453 ms and T wave inversion in V2. Two sets of blood and urine cultures were negative. Other laboratory findings are presented in Table 1 (column: case 1) . She was admitted for COVID-19 pneumonia and placed on cardiac monitoring due to elevated troponin levels (0.04 ng/ml) and d-dimer (2,631 ng/ml). Additionally, she was started on IV antibiotics (ceftriaxone and azithromycin) and IV fluids. CT scan of the chest on admission incidentally showed cholelithiasis without cholecystitis likely due to acute pancreatitis; amylase and lipase were 1,562 U/L and >900 U/L respectively, and toxicology was negative for alcohol. She was kept NPO; a hepatobiliary iminodiacetic acid (HIDA) scan was performed after she refused a CT scan of the abdomen, which showed no scintigraphic evidence of biliary obstruction. In addition, heparin [5,000 units every 12 hours (Q12H)] was started as standard deep vein thrombosis (DVT) prophylaxis. She had an acute drop in hemoglobin during her stay, and a fecal occult blood test was performed, which came back positive (March 23, 2020). Therefore, heparin was discontinued, and she remained NPO in view of concomitant pancreatitis and was started on an IV proton pump inhibitor. Hemoglobin levels were monitored, and no further drop in hemoglobin level, hematemesis, or melena was observed. Her clinical condition improved, hence diet was modified based on what she could tolerate. During the first four days of admission, she had fluctuating fever spikes ( Figure 1) . Additionally, throughout her stay, she had a few episodes of drops in her oxygen saturation ( Figure 2) . Consequently, she was placed on high flow oxygen cannula (2.0 L/min), and her oxygen saturation subsequently improved ( Table 1 (column: case 2). He developed desaturation with increasing respiratory distress and altered mental status during his medical floor stay. Arterial blood gas (ABG) at 4 L nasal cannula showed hypoxia with PaO 2 of 47 mmHg and O 2 saturation of 78.5% (Figure 4) . Consequently, he was upgraded to the intensive care unit due to the impeding respiratory arrest for close monitoring and further management; however, he refused intubation. During his stay, he began saturating well on a non-rebreather ( Table 3) and was downgraded to the floor. He finished a course of ceftriaxone (1 gm daily IVPB for eight days) and azithromycin (500 mg IVPB daily for seven days) and received hydroxychloroquine (400 mg PO daily) for 10 days while QTc interval and electrolytes level were monitored. Additionally, he received hemodialysis as per his schedule. On April 3, 2020, sputum culture grew Klebsiella pneumonia for which he received antibiotics (meropenem 500 mg daily for three days and ciprofloxacin 500 mg PO daily for two days). His medical condition improved ( Figure 5) , and he was downgraded to the floor after nine days of ICU care. He was eventually discharged on April 11, 2020, with a prescription of 14 days of ciprofloxacin and instructions on social distancing and follow-up appointments. presented for feeling unwell for three days, specifically complaining of headaches, myalgia, dry cough, shortness of breath, and fever. His chest CT scan showed patchy infiltrates throughout both lungs with a ground-glass pattern, more prominent at the periphery and at the lung bases ( Figure 6) . Additionally, a COVID-19 RT-PCR test was positive, and two blood cultures showed no growth. Moreover, the electrocardiogram showed sinus rhythm with a corrected QT interval (QTc) of 418 ms. Other blood test results are shown in Table 1 (column: case 3). Overall, he finished a course of ceftriaxone (1 gm daily for six days), Tamiflu® (Roche Pharma, Basel, Switzerland, 75 mg daily for 10 days), hydroxychloroquine (400 mg for five days), and azithromycin (500 mg daily for four days) while QTc interval and electrolytes level were monitored. During his admission, he had spikes of fever; consequently, he was put on vancomycin and meropenem until he was afebrile for 72 hours. Furthermore, He had a few episodes of the mild drop in his oxygen saturation for which he was put on 2 L nasal cannula, and his saturation subsequently improved ( Table 4) . His symptoms improved gradually (Figures 7, 8) , and he was discharged on April 6, 2020, and advised to practice social distancing. The leading cause of mortality in COVID-19 patients is acute respiratory distress syndrome (ARDS). Some COVID-19 patients present with a cytokine profile resembling secondary haemophagocytic lymphohistiocytosis (sHLH), a fulminant and fatal hypercytokinemia with multiorgan failure, which is most commonly triggered by a viral infection and most frequently presents with fever, cytopenias, and hyperferritinemia with the involvement of the lungs (ARDS) [4] [5] . Systemic elevation in pyrogenic cytokines such as interleukin-6 (IL-6), IL-10, and tumor necrosis factor-α (TNF-α) has been observed, suggesting that COVID-19 triggers hyper inflammation that initiates ARDS via a complex inter-relationship of cytokines and proinflammatory mediators involving humoral and cellular responses [3, 4, 6] . Data suggest that the host immune status may influence the progression of COVID-19. Some studies have shown higher levels of type I interferon (IFN-I) in HIV patients, which may help clear the COVID-19 infection. Additionally, delayed antibody response to COVID-19 in HIV patients has been reported, suggesting a possible influence of immune deficiency in HIV patients on clearance of COVID-19 [7] . The impact of multiple anti-retroviral drugs such as lopinavir-boosted ritonavir, darunavir, and remdesivir on COVID-19 has been studied. A case report by Holshue et al. showed clinical improvement in the first case of COVID-19 in the United States after the use of remdesivir [8] . Currently, Gilead Sciences has initiated two phase-3 studies investigating the efficacy of remdesivir for the treatment of COVID-19 [9] . Clinical trials have shown varying levels of effectiveness of lopinavir-boosted ritonavir on reducing mortality rates in COVID-19 patients. Some reports suggest that the addition of lopinavir/ritonavir to the initial treatment reduces the overall death rate and intubation rate [10, 11] . Additionally, Janssen has announced that even though anecdotal instances of darunavir being used for the treatment of COVID-19 have been reported, it is ineffective in treating COVID-19 patients due to its low affinity to coronavirus protease [11] [12] . We propose that HIV could have modulated the immune system in these three patients in a way that led to a less severe immune response to COVID-19. Furthermore, the lower severity of COVID-19 in these HIV patients could be explained by the effect of the anti-retroviral medications these patients were taking. In order to confirm the validity of these hypotheses and show that it was not just the heterogenicity playing a role in such less severe immune response to COVID-19, extensive retrospective studies or prospective randomized control studies should be conducted to further evaluate these hypotheses. Additionally, we recommend further studies on anti-retroviral medications and their effect on COVID-19 patients. Human subjects: Consent was obtained by all participants in this study. In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. 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