id	sid	tid	token	lemma	pos
cord-354050-kcn67stj	1	1	key	key	NN
cord-354050-kcn67stj	1	2	:	:	:
cord-354050-kcn67stj	2	1	cord-354050-kcn67stj	cord-354050-kcn67stj	NNP
cord-354050-kcn67stj	2	2	authors	author	NNS
cord-354050-kcn67stj	2	3	:	:	:
cord-354050-kcn67stj	2	4	Shi	Shi	NNP
cord-354050-kcn67stj	2	5	,	,	,
cord-354050-kcn67stj	2	6	Guoli	Guoli	NNP
cord-354050-kcn67stj	2	7	;	;	:
cord-354050-kcn67stj	2	8	Schwartz	Schwartz	NNP
cord-354050-kcn67stj	2	9	,	,	,
cord-354050-kcn67stj	2	10	Olivier	Olivier	NNP
cord-354050-kcn67stj	2	11	;	;	:
cord-354050-kcn67stj	2	12	Compton	Compton	NNP
cord-354050-kcn67stj	2	13	,	,	,
cord-354050-kcn67stj	2	14	Alex	Alex	NNP
cord-354050-kcn67stj	2	15	A.	a.	NN
cord-354050-kcn67stj	3	1	title	title	NN
cord-354050-kcn67stj	3	2	:	:	:
cord-354050-kcn67stj	3	3	More	More	JJR
cord-354050-kcn67stj	3	4	than	than	IN
cord-354050-kcn67stj	3	5	meets	meet	VBZ
cord-354050-kcn67stj	3	6	the	the	DT
cord-354050-kcn67stj	3	7	I	i	NN
cord-354050-kcn67stj	3	8	:	:	:
cord-354050-kcn67stj	3	9	the	the	DT
cord-354050-kcn67stj	3	10	diverse	diverse	JJ
cord-354050-kcn67stj	3	11	antiviral	antiviral	JJ
cord-354050-kcn67stj	3	12	and	and	CC
cord-354050-kcn67stj	3	13	cellular	cellular	JJ
cord-354050-kcn67stj	3	14	functions	function	NNS
cord-354050-kcn67stj	3	15	of	of	IN
cord-354050-kcn67stj	3	16	interferon	interferon	NN
cord-354050-kcn67stj	3	17	-	-	HYPH
cord-354050-kcn67stj	3	18	induced	induce	VBN
cord-354050-kcn67stj	3	19	transmembrane	transmembrane	NN
cord-354050-kcn67stj	3	20	proteins	protein	NNS
cord-354050-kcn67stj	3	21	date	date	NN
cord-354050-kcn67stj	3	22	:	:	:
cord-354050-kcn67stj	3	23	2017	2017	CD
cord-354050-kcn67stj	3	24	-	-	HYPH
cord-354050-kcn67stj	3	25	11	11	CD
cord-354050-kcn67stj	3	26	-	-	SYM
cord-354050-kcn67stj	3	27	21	21	CD
cord-354050-kcn67stj	3	28	journal	journal	NN
cord-354050-kcn67stj	3	29	:	:	:
cord-354050-kcn67stj	4	1	Retrovirology	Retrovirology	NNP
cord-354050-kcn67stj	4	2	DOI	DOI	NNP
cord-354050-kcn67stj	4	3	:	:	:
cord-354050-kcn67stj	4	4	10.1186	10.1186	CD
cord-354050-kcn67stj	4	5	/	/	SYM
cord-354050-kcn67stj	4	6	s12977	s12977	NN
cord-354050-kcn67stj	4	7	-	-	HYPH
cord-354050-kcn67stj	4	8	017	017	CD
cord-354050-kcn67stj	4	9	-	-	HYPH
cord-354050-kcn67stj	4	10	0377-y	0377-y	CD
cord-354050-kcn67stj	5	1	sha	sha	NNP
cord-354050-kcn67stj	5	2	:	:	:
cord-354050-kcn67stj	6	1	617ec397b4376957e6d055f1989e66b158b93f1a	617ec397b4376957e6d055f1989e66b158b93f1a	LS
cord-354050-kcn67stj	6	2	doc_id	doc_id	CD
cord-354050-kcn67stj	7	1	:	:	:
cord-354050-kcn67stj	7	2	354050	354050	CD
cord-354050-kcn67stj	7	3	cord_uid	cord_uid	NNS
cord-354050-kcn67stj	7	4	:	:	:
cord-354050-kcn67stj	7	5	kcn67stj	kcn67stj	VBN
cord-354050-kcn67stj	8	1	The	the	DT
cord-354050-kcn67stj	8	2	first	first	JJ
cord-354050-kcn67stj	8	3	responders	responder	NNS
cord-354050-kcn67stj	8	4	of	of	IN
cord-354050-kcn67stj	8	5	human	human	JJ
cord-354050-kcn67stj	8	6	antiviral	antiviral	JJ
cord-354050-kcn67stj	8	7	immunity	immunity	NN
cord-354050-kcn67stj	8	8	are	be	VBP
cord-354050-kcn67stj	8	9	components	component	NNS
cord-354050-kcn67stj	8	10	of	of	IN
cord-354050-kcn67stj	8	11	the	the	DT
cord-354050-kcn67stj	8	12	intrinsic	intrinsic	JJ
cord-354050-kcn67stj	8	13	immune	immune	JJ
cord-354050-kcn67stj	8	14	response	response	NN
cord-354050-kcn67stj	8	15	that	that	WDT
cord-354050-kcn67stj	8	16	reside	reside	VBP
cord-354050-kcn67stj	8	17	within	within	IN
cord-354050-kcn67stj	8	18	each	each	DT
cord-354050-kcn67stj	8	19	and	and	CC
cord-354050-kcn67stj	8	20	every	every	DT
cord-354050-kcn67stj	8	21	one	one	CD
cord-354050-kcn67stj	8	22	of	of	IN
cord-354050-kcn67stj	8	23	our	-PRON-	PRP$
cord-354050-kcn67stj	8	24	cells	cell	NNS
cord-354050-kcn67stj	8	25	.	.	.
cord-354050-kcn67stj	9	1	This	this	DT
cord-354050-kcn67stj	9	2	cell	cell	NN
cord-354050-kcn67stj	9	3	-	-	HYPH
cord-354050-kcn67stj	9	4	autonomous	autonomous	JJ
cord-354050-kcn67stj	9	5	arsenal	arsenal	NN
cord-354050-kcn67stj	9	6	consists	consist	NNS
cord-354050-kcn67stj	9	7	of	of	IN
cord-354050-kcn67stj	9	8	nucleic	nucleic	JJ
cord-354050-kcn67stj	9	9	acid	acid	NN
cord-354050-kcn67stj	9	10	sensors	sensor	NNS
cord-354050-kcn67stj	9	11	and	and	CC
cord-354050-kcn67stj	9	12	antiviral	antiviral	JJ
cord-354050-kcn67stj	9	13	effectors	effector	NNS
cord-354050-kcn67stj	9	14	strategically	strategically	RB
cord-354050-kcn67stj	9	15	placed	place	VBN
cord-354050-kcn67stj	9	16	by	by	IN
cord-354050-kcn67stj	9	17	evolution	evolution	NN
cord-354050-kcn67stj	9	18	to	to	TO
cord-354050-kcn67stj	9	19	detect	detect	VB
cord-354050-kcn67stj	9	20	and	and	CC
cord-354050-kcn67stj	9	21	restrict	restrict	VB
cord-354050-kcn67stj	9	22	invading	invade	VBG
cord-354050-kcn67stj	9	23	viruses	virus	NNS
cord-354050-kcn67stj	9	24	.	.	.
cord-354050-kcn67stj	10	1	While	while	IN
cord-354050-kcn67stj	10	2	some	some	DT
cord-354050-kcn67stj	10	3	factors	factor	NNS
cord-354050-kcn67stj	10	4	are	be	VBP
cord-354050-kcn67stj	10	5	present	present	JJ
cord-354050-kcn67stj	10	6	at	at	IN
cord-354050-kcn67stj	10	7	baseline	baseline	NN
cord-354050-kcn67stj	10	8	to	to	TO
cord-354050-kcn67stj	10	9	allow	allow	VB
cord-354050-kcn67stj	10	10	for	for	IN
cord-354050-kcn67stj	10	11	constant	constant	JJ
cord-354050-kcn67stj	10	12	surveillance	surveillance	NN
cord-354050-kcn67stj	10	13	of	of	IN
cord-354050-kcn67stj	10	14	the	the	DT
cord-354050-kcn67stj	10	15	cell	cell	NN
cord-354050-kcn67stj	10	16	interior	interior	NN
cord-354050-kcn67stj	10	17	,	,	,
cord-354050-kcn67stj	10	18	others	other	NNS
cord-354050-kcn67stj	10	19	are	be	VBP
cord-354050-kcn67stj	10	20	upregulated	upregulate	VBN
cord-354050-kcn67stj	10	21	by	by	IN
cord-354050-kcn67stj	10	22	cytokines	cytokine	NNS
cord-354050-kcn67stj	10	23	(	(	-LRB-
cord-354050-kcn67stj	10	24	such	such	JJ
cord-354050-kcn67stj	10	25	as	as	IN
cord-354050-kcn67stj	10	26	interferons	interferon	NNS
cord-354050-kcn67stj	10	27	)	)	-RRB-
cord-354050-kcn67stj	10	28	that	that	WDT
cord-354050-kcn67stj	10	29	signal	signal	VBP
cord-354050-kcn67stj	10	30	a	a	DT
cord-354050-kcn67stj	10	31	viral	viral	JJ
cord-354050-kcn67stj	10	32	infection	infection	NN
cord-354050-kcn67stj	10	33	underway	underway	JJ
cord-354050-kcn67stj	10	34	in	in	IN
cord-354050-kcn67stj	10	35	neighboring	neighboring	NN
cord-354050-kcn67stj	10	36	cells	cell	NNS
cord-354050-kcn67stj	10	37	.	.	.
cord-354050-kcn67stj	11	1	In	in	IN
cord-354050-kcn67stj	11	2	this	this	DT
cord-354050-kcn67stj	11	3	review	review	NN
cord-354050-kcn67stj	11	4	,	,	,
cord-354050-kcn67stj	11	5	we	-PRON-	PRP
cord-354050-kcn67stj	11	6	highlight	highlight	VBP
cord-354050-kcn67stj	11	7	the	the	DT
cord-354050-kcn67stj	11	8	multiple	multiple	JJ
cord-354050-kcn67stj	11	9	roles	role	NNS
cord-354050-kcn67stj	11	10	played	play	VBN
cord-354050-kcn67stj	11	11	by	by	IN
cord-354050-kcn67stj	11	12	the	the	DT
cord-354050-kcn67stj	11	13	interferon	interferon	NN
cord-354050-kcn67stj	11	14	-	-	HYPH
cord-354050-kcn67stj	11	15	induced	induce	VBN
cord-354050-kcn67stj	11	16	transmembrane	transmembrane	NN
cord-354050-kcn67stj	11	17	(	(	-LRB-
cord-354050-kcn67stj	11	18	IFITM	IFITM	NNP
cord-354050-kcn67stj	11	19	)	)	-RRB-
cord-354050-kcn67stj	11	20	proteins	protein	NNS
cord-354050-kcn67stj	11	21	during	during	IN
cord-354050-kcn67stj	11	22	viral	viral	JJ
cord-354050-kcn67stj	11	23	infection	infection	NN
cord-354050-kcn67stj	11	24	,	,	,
cord-354050-kcn67stj	11	25	with	with	IN
cord-354050-kcn67stj	11	26	focuses	focus	NNS
cord-354050-kcn67stj	11	27	on	on	IN
cord-354050-kcn67stj	11	28	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	11	29	and	and	CC
cord-354050-kcn67stj	11	30	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	11	31	.	.	.
cord-354050-kcn67stj	12	1	Moreover	moreover	RB
cord-354050-kcn67stj	12	2	,	,	,
cord-354050-kcn67stj	12	3	we	-PRON-	PRP
cord-354050-kcn67stj	12	4	discuss	discuss	VBP
cord-354050-kcn67stj	12	5	the	the	DT
cord-354050-kcn67stj	12	6	cellular	cellular	JJ
cord-354050-kcn67stj	12	7	pathways	pathway	NNS
cord-354050-kcn67stj	12	8	in	in	IN
cord-354050-kcn67stj	12	9	which	which	WDT
cord-354050-kcn67stj	12	10	IFITM	IFITM	NNP
cord-354050-kcn67stj	12	11	proteins	protein	NNS
cord-354050-kcn67stj	12	12	are	be	VBP
cord-354050-kcn67stj	12	13	intertwined	intertwine	VBN
cord-354050-kcn67stj	12	14	and	and	CC
cord-354050-kcn67stj	12	15	the	the	DT
cord-354050-kcn67stj	12	16	various	various	JJ
cord-354050-kcn67stj	12	17	functions	function	NNS
cord-354050-kcn67stj	12	18	they	-PRON-	PRP
cord-354050-kcn67stj	12	19	have	have	VBP
cord-354050-kcn67stj	12	20	been	be	VBN
cord-354050-kcn67stj	12	21	ascribed	ascribe	VBN
cord-354050-kcn67stj	12	22	outside	outside	IN
cord-354050-kcn67stj	12	23	the	the	DT
cord-354050-kcn67stj	12	24	context	context	NN
cord-354050-kcn67stj	12	25	of	of	IN
cord-354050-kcn67stj	12	26	infection	infection	NN
cord-354050-kcn67stj	12	27	.	.	.
cord-354050-kcn67stj	13	1	While	while	IN
cord-354050-kcn67stj	13	2	appreciated	appreciate	VBN
cord-354050-kcn67stj	13	3	as	as	IN
cord-354050-kcn67stj	13	4	broadly	broadly	RB
cord-354050-kcn67stj	13	5	-	-	HYPH
cord-354050-kcn67stj	13	6	acting	act	VBG
cord-354050-kcn67stj	13	7	,	,	,
cord-354050-kcn67stj	13	8	potent	potent	JJ
cord-354050-kcn67stj	13	9	restriction	restriction	NN
cord-354050-kcn67stj	13	10	factors	factor	NNS
cord-354050-kcn67stj	13	11	that	that	WDT
cord-354050-kcn67stj	13	12	prevent	prevent	VBP
cord-354050-kcn67stj	13	13	virus	virus	NN
cord-354050-kcn67stj	13	14	infection	infection	NN
cord-354050-kcn67stj	13	15	and	and	CC
cord-354050-kcn67stj	13	16	pathogenesis	pathogenesis	NN
cord-354050-kcn67stj	13	17	in	in	IN
cord-354050-kcn67stj	13	18	cell	cell	NN
cord-354050-kcn67stj	13	19	culture	culture	NN
cord-354050-kcn67stj	13	20	and	and	CC
cord-354050-kcn67stj	13	21	in	in	IN
cord-354050-kcn67stj	13	22	vivo	vivo	NN
cord-354050-kcn67stj	13	23	,	,	,
cord-354050-kcn67stj	13	24	questions	question	NNS
cord-354050-kcn67stj	13	25	remain	remain	VBP
cord-354050-kcn67stj	13	26	regarding	regard	VBG
cord-354050-kcn67stj	13	27	their	-PRON-	PRP$
cord-354050-kcn67stj	13	28	precise	precise	JJ
cord-354050-kcn67stj	13	29	mode	mode	NN
cord-354050-kcn67stj	13	30	of	of	IN
cord-354050-kcn67stj	13	31	action	action	NN
cord-354050-kcn67stj	13	32	and	and	CC
cord-354050-kcn67stj	13	33	importance	importance	NN
cord-354050-kcn67stj	13	34	in	in	IN
cord-354050-kcn67stj	13	35	certain	certain	JJ
cord-354050-kcn67stj	13	36	viral	viral	JJ
cord-354050-kcn67stj	13	37	contexts	context	NNS
cord-354050-kcn67stj	13	38	.	.	.
cord-354050-kcn67stj	14	1	Continued	continue	VBN
cord-354050-kcn67stj	14	2	efforts	effort	NNS
cord-354050-kcn67stj	14	3	to	to	TO
cord-354050-kcn67stj	14	4	study	study	VB
cord-354050-kcn67stj	14	5	IFITM	IFITM	NNP
cord-354050-kcn67stj	14	6	protein	protein	NN
cord-354050-kcn67stj	14	7	function	function	NN
cord-354050-kcn67stj	14	8	will	will	MD
cord-354050-kcn67stj	14	9	further	far	RBR
cord-354050-kcn67stj	14	10	cement	cement	VB
cord-354050-kcn67stj	14	11	their	-PRON-	PRP$
cord-354050-kcn67stj	14	12	status	status	NN
cord-354050-kcn67stj	14	13	as	as	IN
cord-354050-kcn67stj	14	14	critical	critical	JJ
cord-354050-kcn67stj	14	15	host	host	NN
cord-354050-kcn67stj	14	16	determinants	determinant	NNS
cord-354050-kcn67stj	14	17	of	of	IN
cord-354050-kcn67stj	14	18	virus	virus	NN
cord-354050-kcn67stj	14	19	susceptibility	susceptibility	NN
cord-354050-kcn67stj	14	20	and	and	CC
cord-354050-kcn67stj	14	21	prioritize	prioritize	VB
cord-354050-kcn67stj	14	22	them	-PRON-	PRP
cord-354050-kcn67stj	14	23	in	in	IN
cord-354050-kcn67stj	14	24	the	the	DT
cord-354050-kcn67stj	14	25	development	development	NN
cord-354050-kcn67stj	14	26	of	of	IN
cord-354050-kcn67stj	14	27	new	new	JJ
cord-354050-kcn67stj	14	28	antiviral	antiviral	JJ
cord-354050-kcn67stj	14	29	therapies	therapy	NNS
cord-354050-kcn67stj	14	30	.	.	.
cord-354050-kcn67stj	15	1	The	the	DT
cord-354050-kcn67stj	15	2	IFITM	IFITM	NNP
cord-354050-kcn67stj	15	3	protein	protein	NN
cord-354050-kcn67stj	15	4	family	family	NN
cord-354050-kcn67stj	15	5	is	be	VBZ
cord-354050-kcn67stj	15	6	encoded	encode	VBN
cord-354050-kcn67stj	15	7	by	by	IN
cord-354050-kcn67stj	15	8	five	five	CD
cord-354050-kcn67stj	15	9	genes	gene	NNS
cord-354050-kcn67stj	15	10	in	in	IN
cord-354050-kcn67stj	15	11	humans	human	NNS
cord-354050-kcn67stj	15	12	,	,	,
cord-354050-kcn67stj	15	13	including	include	VBG
cord-354050-kcn67stj	15	14	the	the	DT
cord-354050-kcn67stj	15	15	immune	immune	NN
cord-354050-kcn67stj	15	16	-	-	HYPH
cord-354050-kcn67stj	15	17	related	relate	VBN
cord-354050-kcn67stj	15	18	IFITM1	ifitm1	NN
cord-354050-kcn67stj	15	19	,	,	,
cord-354050-kcn67stj	15	20	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	15	21	,	,	,
cord-354050-kcn67stj	15	22	and	and	CC
cord-354050-kcn67stj	15	23	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	15	24	,	,	,
cord-354050-kcn67stj	15	25	as	as	RB
cord-354050-kcn67stj	15	26	well	well	RB
cord-354050-kcn67stj	15	27	as	as	IN
cord-354050-kcn67stj	15	28	IFITM5	IFITM5	NNP
cord-354050-kcn67stj	15	29	and	and	CC
cord-354050-kcn67stj	15	30	IFITM10	IFITM10	NNP
cord-354050-kcn67stj	15	31	which	which	WDT
cord-354050-kcn67stj	15	32	have	have	VBP
cord-354050-kcn67stj	15	33	no	no	DT
cord-354050-kcn67stj	15	34	characterized	characterize	VBN
cord-354050-kcn67stj	15	35	roles	role	NNS
cord-354050-kcn67stj	15	36	in	in	IN
cord-354050-kcn67stj	15	37	immunity	immunity	NN
cord-354050-kcn67stj	15	38	[	[	-LRB-
cord-354050-kcn67stj	15	39	1	1	CD
cord-354050-kcn67stj	15	40	]	]	-RRB-
cord-354050-kcn67stj	15	41	.	.	.
cord-354050-kcn67stj	16	1	Today	today	NN
cord-354050-kcn67stj	16	2	,	,	,
cord-354050-kcn67stj	16	3	IFITM	IFITM	NNP
cord-354050-kcn67stj	16	4	genes	gene	NNS
cord-354050-kcn67stj	16	5	are	be	VBP
cord-354050-kcn67stj	16	6	present	present	JJ
cord-354050-kcn67stj	16	7	in	in	IN
cord-354050-kcn67stj	16	8	many	many	JJ
cord-354050-kcn67stj	16	9	vertebrate	vertebrate	NN
cord-354050-kcn67stj	16	10	animal	animal	NN
cord-354050-kcn67stj	16	11	species	specie	NNS
cord-354050-kcn67stj	16	12	yet	yet	RB
cord-354050-kcn67stj	16	13	they	-PRON-	PRP
cord-354050-kcn67stj	16	14	likely	likely	RB
cord-354050-kcn67stj	16	15	emerged	emerge	VBD
cord-354050-kcn67stj	16	16	in	in	IN
cord-354050-kcn67stj	16	17	early	early	JJ
cord-354050-kcn67stj	16	18	unicellular	unicellular	JJ
cord-354050-kcn67stj	16	19	eukaryotes	eukaryote	NNS
cord-354050-kcn67stj	16	20	via	via	IN
cord-354050-kcn67stj	16	21	horizontal	horizontal	JJ
cord-354050-kcn67stj	16	22	gene	gene	NN
cord-354050-kcn67stj	16	23	transmission	transmission	NN
cord-354050-kcn67stj	16	24	from	from	IN
cord-354050-kcn67stj	16	25	a	a	DT
cord-354050-kcn67stj	16	26	bacterium	bacterium	NN
cord-354050-kcn67stj	16	27	[	[	-LRB-
cord-354050-kcn67stj	16	28	2	2	CD
cord-354050-kcn67stj	16	29	]	]	-RRB-
cord-354050-kcn67stj	16	30	.	.	.
cord-354050-kcn67stj	17	1	Since	since	IN
cord-354050-kcn67stj	17	2	then	then	RB
cord-354050-kcn67stj	17	3	,	,	,
cord-354050-kcn67stj	17	4	species	species	NN
cord-354050-kcn67stj	17	5	-	-	HYPH
cord-354050-kcn67stj	17	6	specific	specific	JJ
cord-354050-kcn67stj	17	7	gene	gene	NN
cord-354050-kcn67stj	17	8	expansions	expansion	NNS
cord-354050-kcn67stj	17	9	have	have	VBP
cord-354050-kcn67stj	17	10	given	give	VBN
cord-354050-kcn67stj	17	11	rise	rise	NN
cord-354050-kcn67stj	17	12	to	to	IN
cord-354050-kcn67stj	17	13	unique	unique	JJ
cord-354050-kcn67stj	17	14	IFITM	IFITM	NNP
cord-354050-kcn67stj	17	15	gene	gene	NN
cord-354050-kcn67stj	17	16	repertoires	repertoire	NNS
cord-354050-kcn67stj	17	17	that	that	WDT
cord-354050-kcn67stj	17	18	vary	vary	VBP
cord-354050-kcn67stj	17	19	at	at	IN
cord-354050-kcn67stj	17	20	the	the	DT
cord-354050-kcn67stj	17	21	level	level	NN
cord-354050-kcn67stj	17	22	of	of	IN
cord-354050-kcn67stj	17	23	sequence	sequence	NN
cord-354050-kcn67stj	17	24	and	and	CC
cord-354050-kcn67stj	17	25	copy	copy	NN
cord-354050-kcn67stj	17	26	number	number	NN
cord-354050-kcn67stj	17	27	[	[	-LRB-
cord-354050-kcn67stj	17	28	3	3	CD
cord-354050-kcn67stj	17	29	]	]	-RRB-
cord-354050-kcn67stj	17	30	[	[	-LRB-
cord-354050-kcn67stj	17	31	4	4	CD
cord-354050-kcn67stj	17	32	]	]	-RRB-
cord-354050-kcn67stj	18	1	[	[	-LRB-
cord-354050-kcn67stj	18	2	5	5	CD
cord-354050-kcn67stj	18	3	]	]	-RRB-
cord-354050-kcn67stj	18	4	.	.	.
cord-354050-kcn67stj	19	1	In	in	IN
cord-354050-kcn67stj	19	2	addition	addition	NN
cord-354050-kcn67stj	19	3	to	to	IN
cord-354050-kcn67stj	19	4	the	the	DT
cord-354050-kcn67stj	19	5	canonical	canonical	JJ
cord-354050-kcn67stj	19	6	IFITM	IFITM	NNP
cord-354050-kcn67stj	19	7	gene	gene	NN
cord-354050-kcn67stj	19	8	locus	locus	NN
cord-354050-kcn67stj	19	9	on	on	IN
cord-354050-kcn67stj	19	10	chromosome	chromosome	NN
cord-354050-kcn67stj	19	11	11	11	CD
cord-354050-kcn67stj	19	12	in	in	IN
cord-354050-kcn67stj	19	13	humans	human	NNS
cord-354050-kcn67stj	19	14	,	,	,
cord-354050-kcn67stj	19	15	there	there	EX
cord-354050-kcn67stj	19	16	are	be	VBP
cord-354050-kcn67stj	19	17	a	a	DT
cord-354050-kcn67stj	19	18	number	number	NN
cord-354050-kcn67stj	19	19	of	of	IN
cord-354050-kcn67stj	19	20	IFITM	IFITM	NNP
cord-354050-kcn67stj	19	21	-	-	HYPH
cord-354050-kcn67stj	19	22	like	like	JJ
cord-354050-kcn67stj	19	23	genes	gene	NNS
cord-354050-kcn67stj	19	24	dispersed	disperse	VBN
cord-354050-kcn67stj	19	25	throughout	throughout	IN
cord-354050-kcn67stj	19	26	our	-PRON-	PRP$
cord-354050-kcn67stj	19	27	genome	genome	NN
cord-354050-kcn67stj	19	28	for	for	IN
cord-354050-kcn67stj	19	29	which	which	WDT
cord-354050-kcn67stj	19	30	a	a	DT
cord-354050-kcn67stj	19	31	functional	functional	JJ
cord-354050-kcn67stj	19	32	understanding	understanding	NN
cord-354050-kcn67stj	19	33	is	be	VBZ
cord-354050-kcn67stj	19	34	lacking	lack	VBG
cord-354050-kcn67stj	19	35	[	[	-LRB-
cord-354050-kcn67stj	19	36	2	2	CD
cord-354050-kcn67stj	19	37	]	]	-RRB-
cord-354050-kcn67stj	19	38	.	.	.
cord-354050-kcn67stj	20	1	Despite	despite	IN
cord-354050-kcn67stj	20	2	what	what	WP
cord-354050-kcn67stj	20	3	their	-PRON-	PRP$
cord-354050-kcn67stj	20	4	name	name	NN
cord-354050-kcn67stj	20	5	implies	imply	VBZ
cord-354050-kcn67stj	20	6	,	,	,
cord-354050-kcn67stj	20	7	only	only	RB
cord-354050-kcn67stj	20	8	the	the	DT
cord-354050-kcn67stj	20	9	immune	immune	NN
cord-354050-kcn67stj	20	10	-	-	HYPH
cord-354050-kcn67stj	20	11	related	relate	VBN
cord-354050-kcn67stj	20	12	IFITM	IFITM	NNP
cord-354050-kcn67stj	20	13	genes	gene	NNS
cord-354050-kcn67stj	20	14	are	be	VBP
cord-354050-kcn67stj	20	15	interferon	interferon	NN
cord-354050-kcn67stj	20	16	-	-	HYPH
cord-354050-kcn67stj	20	17	inducible	inducible	JJ
cord-354050-kcn67stj	20	18	,	,	,
cord-354050-kcn67stj	20	19	and	and	CC
cord-354050-kcn67stj	20	20	furthermore	furthermore	RB
cord-354050-kcn67stj	20	21	,	,	,
cord-354050-kcn67stj	20	22	moderate	moderate	JJ
cord-354050-kcn67stj	20	23	to	to	IN
cord-354050-kcn67stj	20	24	high	high	JJ
cord-354050-kcn67stj	20	25	levels	level	NNS
cord-354050-kcn67stj	20	26	of	of	IN
cord-354050-kcn67stj	20	27	expression	expression	NN
cord-354050-kcn67stj	20	28	may	may	MD
cord-354050-kcn67stj	20	29	be	be	VB
cord-354050-kcn67stj	20	30	seen	see	VBN
cord-354050-kcn67stj	20	31	in	in	IN
cord-354050-kcn67stj	20	32	several	several	JJ
cord-354050-kcn67stj	20	33	tissue	tissue	NN
cord-354050-kcn67stj	20	34	types	type	NNS
cord-354050-kcn67stj	20	35	even	even	RB
cord-354050-kcn67stj	20	36	in	in	IN
cord-354050-kcn67stj	20	37	the	the	DT
cord-354050-kcn67stj	20	38	absence	absence	NN
cord-354050-kcn67stj	20	39	of	of	IN
cord-354050-kcn67stj	20	40	interferon	interferon	NN
cord-354050-kcn67stj	20	41	.	.	.
cord-354050-kcn67stj	21	1	The	the	DT
cord-354050-kcn67stj	21	2	immunological	immunological	JJ
cord-354050-kcn67stj	21	3	and	and	CC
cord-354050-kcn67stj	21	4	clinical	clinical	JJ
cord-354050-kcn67stj	21	5	importance	importance	NN
cord-354050-kcn67stj	21	6	of	of	IN
cord-354050-kcn67stj	21	7	IFITM	IFITM	NNP
cord-354050-kcn67stj	21	8	proteins	protein	NNS
cord-354050-kcn67stj	21	9	to	to	TO
cord-354050-kcn67stj	21	10	innate	innate	JJ
cord-354050-kcn67stj	21	11	immunity	immunity	NN
cord-354050-kcn67stj	21	12	is	be	VBZ
cord-354050-kcn67stj	21	13	tied	tie	VBN
cord-354050-kcn67stj	21	14	to	to	IN
cord-354050-kcn67stj	21	15	their	-PRON-	PRP$
cord-354050-kcn67stj	21	16	unique	unique	JJ
cord-354050-kcn67stj	21	17	ability	ability	NN
cord-354050-kcn67stj	21	18	to	to	TO
cord-354050-kcn67stj	21	19	inhibit	inhibit	VB
cord-354050-kcn67stj	21	20	the	the	DT
cord-354050-kcn67stj	21	21	earliest	early	JJS
cord-354050-kcn67stj	21	22	step	step	NN
cord-354050-kcn67stj	21	23	of	of	IN
cord-354050-kcn67stj	21	24	the	the	DT
cord-354050-kcn67stj	21	25	virus	virus	NN
cord-354050-kcn67stj	21	26	life	life	NN
cord-354050-kcn67stj	21	27	cycle	cycle	NN
cord-354050-kcn67stj	21	28	:	:	:
cord-354050-kcn67stj	21	29	entry	entry	NN
cord-354050-kcn67stj	21	30	into	into	IN
cord-354050-kcn67stj	21	31	cells	cell	NNS
cord-354050-kcn67stj	21	32	.	.	.
cord-354050-kcn67stj	22	1	As	as	IN
cord-354050-kcn67stj	22	2	a	a	DT
cord-354050-kcn67stj	22	3	result	result	NN
cord-354050-kcn67stj	22	4	,	,	,
cord-354050-kcn67stj	22	5	they	-PRON-	PRP
cord-354050-kcn67stj	22	6	prevent	prevent	VBP
cord-354050-kcn67stj	22	7	not	not	RB
cord-354050-kcn67stj	22	8	only	only	RB
cord-354050-kcn67stj	22	9	viral	viral	JJ
cord-354050-kcn67stj	22	10	replication	replication	NN
cord-354050-kcn67stj	22	11	but	but	CC
cord-354050-kcn67stj	22	12	also	also	RB
cord-354050-kcn67stj	22	13	the	the	DT
cord-354050-kcn67stj	22	14	sequelae	sequela	NNS
cord-354050-kcn67stj	22	15	of	of	IN
cord-354050-kcn67stj	22	16	virus	virus	NN
cord-354050-kcn67stj	22	17	-	-	HYPH
cord-354050-kcn67stj	22	18	associated	associate	VBN
cord-354050-kcn67stj	22	19	disease	disease	NN
cord-354050-kcn67stj	22	20	,	,	,
cord-354050-kcn67stj	22	21	such	such	JJ
cord-354050-kcn67stj	22	22	as	as	IN
cord-354050-kcn67stj	22	23	cytopathicity	cytopathicity	NN
cord-354050-kcn67stj	22	24	(	(	-LRB-
cord-354050-kcn67stj	22	25	cell	cell	NN
cord-354050-kcn67stj	22	26	death	death	NN
cord-354050-kcn67stj	22	27	)	)	-RRB-
cord-354050-kcn67stj	22	28	and	and	CC
cord-354050-kcn67stj	22	29	inflammation	inflammation	NN
cord-354050-kcn67stj	22	30	.	.	.
cord-354050-kcn67stj	23	1	Initially	initially	RB
cord-354050-kcn67stj	23	2	revealed	reveal	VBD
cord-354050-kcn67stj	23	3	to	to	TO
cord-354050-kcn67stj	23	4	be	be	VB
cord-354050-kcn67stj	23	5	endogenous	endogenous	JJ
cord-354050-kcn67stj	23	6	inhibitors	inhibitor	NNS
cord-354050-kcn67stj	23	7	of	of	IN
cord-354050-kcn67stj	23	8	Influenza	Influenza	NNP
cord-354050-kcn67stj	23	9	A	a	DT
cord-354050-kcn67stj	23	10	virus	virus	NN
cord-354050-kcn67stj	23	11	(	(	-LRB-
cord-354050-kcn67stj	23	12	IAV	IAV	NNP
cord-354050-kcn67stj	23	13	)	)	-RRB-
cord-354050-kcn67stj	23	14	,	,	,
cord-354050-kcn67stj	23	15	West	West	NNP
cord-354050-kcn67stj	23	16	Nile	Nile	NNP
cord-354050-kcn67stj	23	17	virus	virus	NN
cord-354050-kcn67stj	23	18	(	(	-LRB-
cord-354050-kcn67stj	23	19	WNV	WNV	NNP
cord-354050-kcn67stj	23	20	)	)	-RRB-
cord-354050-kcn67stj	23	21	,	,	,
cord-354050-kcn67stj	23	22	and	and	CC
cord-354050-kcn67stj	23	23	Dengue	Dengue	NNP
cord-354050-kcn67stj	23	24	virus	virus	NN
cord-354050-kcn67stj	23	25	,	,	,
cord-354050-kcn67stj	23	26	today	today	NN
cord-354050-kcn67stj	23	27	it	-PRON-	PRP
cord-354050-kcn67stj	23	28	is	be	VBZ
cord-354050-kcn67stj	23	29	recognized	recognize	VBN
cord-354050-kcn67stj	23	30	that	that	IN
cord-354050-kcn67stj	23	31	a	a	DT
cord-354050-kcn67stj	23	32	growing	grow	VBG
cord-354050-kcn67stj	23	33	list	list	NN
cord-354050-kcn67stj	23	34	of	of	IN
cord-354050-kcn67stj	23	35	viruses	virus	NNS
cord-354050-kcn67stj	23	36	are	be	VBP
cord-354050-kcn67stj	23	37	sensitive	sensitive	JJ
cord-354050-kcn67stj	23	38	to	to	IN
cord-354050-kcn67stj	23	39	IFITM	IFITM	NNP
cord-354050-kcn67stj	23	40	-	-	HYPH
cord-354050-kcn67stj	23	41	mediated	mediate	VBN
cord-354050-kcn67stj	23	42	restriction	restriction	NN
cord-354050-kcn67stj	23	43	[	[	-LRB-
cord-354050-kcn67stj	23	44	6	6	CD
cord-354050-kcn67stj	23	45	,	,	,
cord-354050-kcn67stj	23	46	7	7	CD
cord-354050-kcn67stj	23	47	]	]	-RRB-
cord-354050-kcn67stj	23	48	.	.	.
cord-354050-kcn67stj	24	1	The	the	DT
cord-354050-kcn67stj	24	2	use	use	NN
cord-354050-kcn67stj	24	3	of	of	IN
cord-354050-kcn67stj	24	4	retroviral	retroviral	NN
cord-354050-kcn67stj	24	5	"	"	``
cord-354050-kcn67stj	24	6	pseudotypes	pseudotype	NNS
cord-354050-kcn67stj	24	7	,	,	,
cord-354050-kcn67stj	24	8	"	"	''
cord-354050-kcn67stj	24	9	in	in	IN
cord-354050-kcn67stj	24	10	which	which	WDT
cord-354050-kcn67stj	24	11	different	different	JJ
cord-354050-kcn67stj	24	12	viral	viral	JJ
cord-354050-kcn67stj	24	13	envelope	envelope	NN
cord-354050-kcn67stj	24	14	glycoproteins	glycoprotein	NNS
cord-354050-kcn67stj	24	15	are	be	VBP
cord-354050-kcn67stj	24	16	swapped	swap	VBN
cord-354050-kcn67stj	24	17	into	into	IN
cord-354050-kcn67stj	24	18	the	the	DT
cord-354050-kcn67stj	24	19	same	same	JJ
cord-354050-kcn67stj	24	20	retrovirus	retrovirus	NN
cord-354050-kcn67stj	24	21	capsid	capsid	NN
cord-354050-kcn67stj	24	22	core	core	NN
cord-354050-kcn67stj	24	23	,	,	,
cord-354050-kcn67stj	24	24	demonstrated	demonstrate	VBD
cord-354050-kcn67stj	24	25	that	that	IN
cord-354050-kcn67stj	24	26	the	the	DT
cord-354050-kcn67stj	24	27	route	route	NN
cord-354050-kcn67stj	24	28	of	of	IN
cord-354050-kcn67stj	24	29	cellular	cellular	JJ
cord-354050-kcn67stj	24	30	entry	entry	NN
cord-354050-kcn67stj	24	31	is	be	VBZ
cord-354050-kcn67stj	24	32	a	a	DT
cord-354050-kcn67stj	24	33	major	major	JJ
cord-354050-kcn67stj	24	34	determinant	determinant	NN
cord-354050-kcn67stj	24	35	of	of	IN
cord-354050-kcn67stj	24	36	restriction	restriction	NN
cord-354050-kcn67stj	24	37	and	and	CC
cord-354050-kcn67stj	24	38	identified	identify	VBD
cord-354050-kcn67stj	24	39	strains	strain	NNS
cord-354050-kcn67stj	24	40	exhibiting	exhibit	VBG
cord-354050-kcn67stj	24	41	resistance	resistance	NN
cord-354050-kcn67stj	24	42	.	.	.
cord-354050-kcn67stj	25	1	In	in	IN
cord-354050-kcn67stj	25	2	general	general	JJ
cord-354050-kcn67stj	25	3	,	,	,
cord-354050-kcn67stj	25	4	those	those	DT
cord-354050-kcn67stj	25	5	that	that	WDT
cord-354050-kcn67stj	25	6	require	require	VBP
cord-354050-kcn67stj	25	7	a	a	DT
cord-354050-kcn67stj	25	8	pH	ph	NN
cord-354050-kcn67stj	25	9	-	-	HYPH
cord-354050-kcn67stj	25	10	dependent	dependent	JJ
cord-354050-kcn67stj	25	11	triggering	triggering	NN
cord-354050-kcn67stj	25	12	of	of	IN
cord-354050-kcn67stj	25	13	viral	viral	JJ
cord-354050-kcn67stj	25	14	fusion	fusion	NN
cord-354050-kcn67stj	25	15	machinery	machinery	NN
cord-354050-kcn67stj	25	16	in	in	IN
cord-354050-kcn67stj	25	17	endosomes	endosome	NNS
cord-354050-kcn67stj	25	18	are	be	VBP
cord-354050-kcn67stj	25	19	the	the	DT
cord-354050-kcn67stj	25	20	most	most	RBS
cord-354050-kcn67stj	25	21	affected	affect	VBN
cord-354050-kcn67stj	25	22	when	when	WRB
cord-354050-kcn67stj	25	23	IFITM	IFITM	NNP
cord-354050-kcn67stj	25	24	proteins	protein	NNS
cord-354050-kcn67stj	25	25	,	,	,
cord-354050-kcn67stj	25	26	in	in	IN
cord-354050-kcn67stj	25	27	particular	particular	JJ
cord-354050-kcn67stj	25	28	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	25	29	,	,	,
cord-354050-kcn67stj	25	30	are	be	VBP
cord-354050-kcn67stj	25	31	overexpressed	overexpresse	VBN
cord-354050-kcn67stj	25	32	or	or	CC
cord-354050-kcn67stj	25	33	silenced	silence	VBN
cord-354050-kcn67stj	25	34	in	in	IN
cord-354050-kcn67stj	25	35	cells	cell	NNS
cord-354050-kcn67stj	25	36	[	[	-LRB-
cord-354050-kcn67stj	25	37	8	8	CD
cord-354050-kcn67stj	25	38	]	]	-RRB-
cord-354050-kcn67stj	25	39	[	[	-LRB-
cord-354050-kcn67stj	25	40	9	9	CD
cord-354050-kcn67stj	25	41	]	]	-RRB-
cord-354050-kcn67stj	25	42	[	[	-LRB-
cord-354050-kcn67stj	25	43	10	10	CD
cord-354050-kcn67stj	25	44	]	]	-RRB-
cord-354050-kcn67stj	25	45	.	.	.
cord-354050-kcn67stj	26	1	These	these	DT
cord-354050-kcn67stj	26	2	findings	finding	NNS
cord-354050-kcn67stj	26	3	suggested	suggest	VBD
cord-354050-kcn67stj	26	4	that	that	IN
cord-354050-kcn67stj	26	5	IFITM	IFITM	NNP
cord-354050-kcn67stj	26	6	-	-	HYPH
cord-354050-kcn67stj	26	7	mediated	mediate	VBN
cord-354050-kcn67stj	26	8	antiviral	antiviral	JJ
cord-354050-kcn67stj	26	9	activity	activity	NN
cord-354050-kcn67stj	26	10	manifests	manifest	VBZ
cord-354050-kcn67stj	26	11	at	at	IN
cord-354050-kcn67stj	26	12	the	the	DT
cord-354050-kcn67stj	26	13	entry	entry	NN
cord-354050-kcn67stj	26	14	stage	stage	NN
cord-354050-kcn67stj	26	15	.	.	.
cord-354050-kcn67stj	27	1	The	the	DT
cord-354050-kcn67stj	27	2	subcellular	subcellular	JJ
cord-354050-kcn67stj	27	3	localization	localization	NN
cord-354050-kcn67stj	27	4	of	of	IN
cord-354050-kcn67stj	27	5	IFITM	IFITM	NNP
cord-354050-kcn67stj	27	6	proteins	protein	NNS
cord-354050-kcn67stj	27	7	is	be	VBZ
cord-354050-kcn67stj	27	8	important	important	JJ
cord-354050-kcn67stj	27	9	to	to	IN
cord-354050-kcn67stj	27	10	our	-PRON-	PRP$
cord-354050-kcn67stj	27	11	understanding	understanding	NN
cord-354050-kcn67stj	27	12	of	of	IN
cord-354050-kcn67stj	27	13	how	how	WRB
cord-354050-kcn67stj	27	14	virus	virus	NN
cord-354050-kcn67stj	27	15	entry	entry	NN
cord-354050-kcn67stj	27	16	is	be	VBZ
cord-354050-kcn67stj	27	17	inhibited	inhibit	VBN
cord-354050-kcn67stj	27	18	.	.	.
cord-354050-kcn67stj	28	1	They	-PRON-	PRP
cord-354050-kcn67stj	28	2	are	be	VBP
cord-354050-kcn67stj	28	3	regularly	regularly	RB
cord-354050-kcn67stj	28	4	detected	detect	VBN
cord-354050-kcn67stj	28	5	in	in	IN
cord-354050-kcn67stj	28	6	endosomes	endosome	NNS
cord-354050-kcn67stj	28	7	,	,	,
cord-354050-kcn67stj	28	8	lysosomes	lysosome	NNS
cord-354050-kcn67stj	28	9	,	,	,
cord-354050-kcn67stj	28	10	autophagosomes	autophagosomes	NNP
cord-354050-kcn67stj	28	11	,	,	,
cord-354050-kcn67stj	28	12	and	and	CC
cord-354050-kcn67stj	28	13	the	the	DT
cord-354050-kcn67stj	28	14	plasma	plasma	NN
cord-354050-kcn67stj	28	15	membrane	membrane	NN
cord-354050-kcn67stj	28	16	,	,	,
cord-354050-kcn67stj	28	17	and	and	CC
cord-354050-kcn67stj	28	18	the	the	DT
cord-354050-kcn67stj	28	19	extent	extent	NN
cord-354050-kcn67stj	28	20	of	of	IN
cord-354050-kcn67stj	28	21	which	which	WDT
cord-354050-kcn67stj	28	22	can	can	MD
cord-354050-kcn67stj	28	23	vary	vary	VB
cord-354050-kcn67stj	28	24	by	by	IN
cord-354050-kcn67stj	28	25	cell	cell	NN
cord-354050-kcn67stj	28	26	type	type	NN
cord-354050-kcn67stj	28	27	and	and	CC
cord-354050-kcn67stj	28	28	by	by	IN
cord-354050-kcn67stj	28	29	IFITM	IFITM	NNP
cord-354050-kcn67stj	28	30	family	family	NN
cord-354050-kcn67stj	28	31	member	member	NN
cord-354050-kcn67stj	28	32	.	.	.
cord-354050-kcn67stj	29	1	Their	-PRON-	PRP$
cord-354050-kcn67stj	29	2	presence	presence	NN
cord-354050-kcn67stj	29	3	at	at	IN
cord-354050-kcn67stj	29	4	various	various	JJ
cord-354050-kcn67stj	29	5	cellular	cellular	JJ
cord-354050-kcn67stj	29	6	compartments	compartment	NNS
cord-354050-kcn67stj	29	7	is	be	VBZ
cord-354050-kcn67stj	29	8	the	the	DT
cord-354050-kcn67stj	29	9	result	result	NN
cord-354050-kcn67stj	29	10	of	of	IN
cord-354050-kcn67stj	29	11	dynamic	dynamic	JJ
cord-354050-kcn67stj	29	12	protein	protein	NN
cord-354050-kcn67stj	29	13	trafficking	trafficking	NN
cord-354050-kcn67stj	29	14	that	that	WDT
cord-354050-kcn67stj	29	15	begins	begin	VBZ
cord-354050-kcn67stj	29	16	with	with	IN
cord-354050-kcn67stj	29	17	de	de	FW
cord-354050-kcn67stj	29	18	novo	novo	NNP
cord-354050-kcn67stj	29	19	synthesis	synthesis	NN
cord-354050-kcn67stj	29	20	in	in	IN
cord-354050-kcn67stj	29	21	the	the	DT
cord-354050-kcn67stj	29	22	endoplasmic	endoplasmic	NN
cord-354050-kcn67stj	29	23	reticulum	reticulum	NN
cord-354050-kcn67stj	29	24	and	and	CC
cord-354050-kcn67stj	29	25	ends	end	VBZ
cord-354050-kcn67stj	29	26	with	with	IN
cord-354050-kcn67stj	29	27	degradation	degradation	NN
cord-354050-kcn67stj	29	28	in	in	IN
cord-354050-kcn67stj	29	29	lysosomes	lysosome	NNS
cord-354050-kcn67stj	29	30	[	[	-LRB-
cord-354050-kcn67stj	29	31	11	11	CD
cord-354050-kcn67stj	29	32	]	]	-RRB-
cord-354050-kcn67stj	29	33	.	.	.
cord-354050-kcn67stj	30	1	Multiple	multiple	JJ
cord-354050-kcn67stj	30	2	pieces	piece	NNS
cord-354050-kcn67stj	30	3	of	of	IN
cord-354050-kcn67stj	30	4	evidence	evidence	NN
cord-354050-kcn67stj	30	5	suggest	suggest	VBP
cord-354050-kcn67stj	30	6	that	that	IN
cord-354050-kcn67stj	30	7	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	30	8	takes	take	VBZ
cord-354050-kcn67stj	30	9	on	on	RP
cord-354050-kcn67stj	30	10	a	a	DT
cord-354050-kcn67stj	30	11	type	type	NN
cord-354050-kcn67stj	30	12	II	II	NNP
cord-354050-kcn67stj	30	13	transmembrane	transmembrane	NN
cord-354050-kcn67stj	30	14	protein	protein	NN
cord-354050-kcn67stj	30	15	topology	topology	NN
cord-354050-kcn67stj	30	16	,	,	,
cord-354050-kcn67stj	30	17	with	with	IN
cord-354050-kcn67stj	30	18	a	a	DT
cord-354050-kcn67stj	30	19	cytosolic	cytosolic	JJ
cord-354050-kcn67stj	30	20	aminoterminus	aminoterminus	NN
cord-354050-kcn67stj	30	21	,	,	,
cord-354050-kcn67stj	30	22	a	a	DT
cord-354050-kcn67stj	30	23	luminal	luminal	JJ
cord-354050-kcn67stj	30	24	/	/	SYM
cord-354050-kcn67stj	30	25	extracellular	extracellular	JJ
cord-354050-kcn67stj	30	26	carboxy	carboxy	JJ
cord-354050-kcn67stj	30	27	-	-	HYPH
cord-354050-kcn67stj	30	28	terminus	terminus	NN
cord-354050-kcn67stj	30	29	,	,	,
cord-354050-kcn67stj	30	30	and	and	CC
cord-354050-kcn67stj	30	31	two	two	CD
cord-354050-kcn67stj	30	32	hydrophobic	hydrophobic	JJ
cord-354050-kcn67stj	30	33	domains	domain	NNS
cord-354050-kcn67stj	30	34	:	:	:
cord-354050-kcn67stj	30	35	one	one	CD
cord-354050-kcn67stj	30	36	intramembrane	intramembrane	NNP
cord-354050-kcn67stj	30	37	domain	domain	NN
cord-354050-kcn67stj	30	38	(	(	-LRB-
cord-354050-kcn67stj	30	39	HD1	HD1	VBZ
cord-354050-kcn67stj	30	40	)	)	-RRB-
cord-354050-kcn67stj	30	41	and	and	CC
cord-354050-kcn67stj	30	42	one	one	CD
cord-354050-kcn67stj	30	43	transmembrane	transmembrane	NN
cord-354050-kcn67stj	30	44	domain	domain	NN
cord-354050-kcn67stj	30	45	(	(	-LRB-
cord-354050-kcn67stj	30	46	HD2	HD2	NNP
cord-354050-kcn67stj	30	47	)	)	-RRB-
cord-354050-kcn67stj	30	48	[	[	-LRB-
cord-354050-kcn67stj	30	49	12	12	CD
cord-354050-kcn67stj	30	50	]	]	-RRB-
cord-354050-kcn67stj	30	51	[	[	-LRB-
cord-354050-kcn67stj	30	52	13	13	CD
cord-354050-kcn67stj	30	53	]	]	-RRB-
cord-354050-kcn67stj	30	54	[	[	-LRB-
cord-354050-kcn67stj	30	55	14	14	CD
cord-354050-kcn67stj	30	56	]	]	-RRB-
cord-354050-kcn67stj	30	57	.	.	.
cord-354050-kcn67stj	31	1	Interestingly	interestingly	RB
cord-354050-kcn67stj	31	2	,	,	,
cord-354050-kcn67stj	31	3	there	there	EX
cord-354050-kcn67stj	31	4	is	be	VBZ
cord-354050-kcn67stj	31	5	also	also	RB
cord-354050-kcn67stj	31	6	support	support	NN
cord-354050-kcn67stj	31	7	for	for	IN
cord-354050-kcn67stj	31	8	alternative	alternative	JJ
cord-354050-kcn67stj	31	9	membrane	membrane	NN
cord-354050-kcn67stj	31	10	topologies	topology	NNS
cord-354050-kcn67stj	31	11	in	in	IN
cord-354050-kcn67stj	31	12	which	which	WDT
cord-354050-kcn67stj	31	13	the	the	DT
cord-354050-kcn67stj	31	14	termini	termini	JJ
cord-354050-kcn67stj	31	15	orientations	orientation	NNS
cord-354050-kcn67stj	31	16	are	be	VBP
cord-354050-kcn67stj	31	17	reversed	reverse	VBN
cord-354050-kcn67stj	31	18	[	[	-LRB-
cord-354050-kcn67stj	31	19	13	13	CD
cord-354050-kcn67stj	31	20	]	]	-RRB-
cord-354050-kcn67stj	31	21	.	.	.
cord-354050-kcn67stj	32	1	The	the	DT
cord-354050-kcn67stj	32	2	hydrophobic	hydrophobic	JJ
cord-354050-kcn67stj	32	3	domains	domain	NNS
cord-354050-kcn67stj	32	4	of	of	IN
cord-354050-kcn67stj	32	5	IFITM	IFITM	NNP
cord-354050-kcn67stj	32	6	members	member	NNS
cord-354050-kcn67stj	32	7	ensure	ensure	VBP
cord-354050-kcn67stj	32	8	movement	movement	NN
cord-354050-kcn67stj	32	9	between	between	IN
cord-354050-kcn67stj	32	10	membrane	membrane	NN
cord-354050-kcn67stj	32	11	-	-	HYPH
cord-354050-kcn67stj	32	12	enclosed	enclose	VBN
cord-354050-kcn67stj	32	13	vesicles	vesicle	NNS
cord-354050-kcn67stj	32	14	in	in	IN
cord-354050-kcn67stj	32	15	the	the	DT
cord-354050-kcn67stj	32	16	biosynthetic	biosynthetic	JJ
cord-354050-kcn67stj	32	17	-	-	HYPH
cord-354050-kcn67stj	32	18	secretory	secretory	NN
cord-354050-kcn67stj	32	19	pathway	pathway	NN
cord-354050-kcn67stj	32	20	,	,	,
cord-354050-kcn67stj	32	21	and	and	CC
cord-354050-kcn67stj	32	22	posttranslational	posttranslational	JJ
cord-354050-kcn67stj	32	23	lipidification	lipidification	NN
cord-354050-kcn67stj	32	24	with	with	IN
cord-354050-kcn67stj	32	25	an	an	DT
cord-354050-kcn67stj	32	26	S	S	NNP
cord-354050-kcn67stj	32	27	-	-	HYPH
cord-354050-kcn67stj	32	28	palmitoyl	palmitoyl	NN
cord-354050-kcn67stj	32	29	group	group	NN
cord-354050-kcn67stj	32	30	promotes	promote	VBZ
cord-354050-kcn67stj	32	31	durable	durable	JJ
cord-354050-kcn67stj	32	32	membrane	membrane	NN
cord-354050-kcn67stj	32	33	associations	association	NNS
cord-354050-kcn67stj	32	34	[	[	-LRB-
cord-354050-kcn67stj	32	35	15	15	CD
cord-354050-kcn67stj	32	36	,	,	,
cord-354050-kcn67stj	32	37	16	16	CD
cord-354050-kcn67stj	32	38	]	]	-RRB-
cord-354050-kcn67stj	32	39	.	.	.
cord-354050-kcn67stj	33	1	After	after	IN
cord-354050-kcn67stj	33	2	passage	passage	NN
cord-354050-kcn67stj	33	3	through	through	IN
cord-354050-kcn67stj	33	4	the	the	DT
cord-354050-kcn67stj	33	5	endoplasmic	endoplasmic	NN
cord-354050-kcn67stj	33	6	reticulum	reticulum	NN
cord-354050-kcn67stj	33	7	,	,	,
cord-354050-kcn67stj	33	8	golgi	golgi	NN
cord-354050-kcn67stj	33	9	complex	complex	NN
cord-354050-kcn67stj	33	10	,	,	,
cord-354050-kcn67stj	33	11	and	and	CC
cord-354050-kcn67stj	33	12	plasma	plasma	NN
cord-354050-kcn67stj	33	13	membrane	membrane	NN
cord-354050-kcn67stj	33	14	,	,	,
cord-354050-kcn67stj	33	15	endocytic	endocytic	JJ
cord-354050-kcn67stj	33	16	sorting	sorting	NN
cord-354050-kcn67stj	33	17	motifs	motif	NNS
cord-354050-kcn67stj	33	18	in	in	IN
cord-354050-kcn67stj	33	19	the	the	DT
cord-354050-kcn67stj	33	20	amino	amino	NN
cord-354050-kcn67stj	33	21	-	-	HYPH
cord-354050-kcn67stj	33	22	terminus	terminus	NN
cord-354050-kcn67stj	33	23	of	of	IN
cord-354050-kcn67stj	33	24	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	33	25	and	and	CC
cord-354050-kcn67stj	33	26	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	33	27	allow	allow	VB
cord-354050-kcn67stj	33	28	internalization	internalization	NN
cord-354050-kcn67stj	33	29	into	into	IN
cord-354050-kcn67stj	33	30	endosomes	endosome	NNS
cord-354050-kcn67stj	33	31	,	,	,
cord-354050-kcn67stj	33	32	and	and	CC
cord-354050-kcn67stj	33	33	this	this	DT
cord-354050-kcn67stj	33	34	positioning	positioning	NN
cord-354050-kcn67stj	33	35	is	be	VBZ
cord-354050-kcn67stj	33	36	crucial	crucial	JJ
cord-354050-kcn67stj	33	37	for	for	IN
cord-354050-kcn67stj	33	38	antiviral	antiviral	JJ
cord-354050-kcn67stj	33	39	activity	activity	NN
cord-354050-kcn67stj	33	40	[	[	-LRB-
cord-354050-kcn67stj	33	41	5	5	CD
cord-354050-kcn67stj	33	42	,	,	,
cord-354050-kcn67stj	33	43	17	17	CD
cord-354050-kcn67stj	33	44	,	,	,
cord-354050-kcn67stj	33	45	18	18	CD
cord-354050-kcn67stj	33	46	]	]	-RRB-
cord-354050-kcn67stj	33	47	.	.	.
cord-354050-kcn67stj	34	1	Late	late	JJ
cord-354050-kcn67stj	34	2	endosomes	endosome	NNS
cord-354050-kcn67stj	34	3	,	,	,
cord-354050-kcn67stj	34	4	multivesicular	multivesicular	JJ
cord-354050-kcn67stj	34	5	bodies	body	NNS
cord-354050-kcn67stj	34	6	,	,	,
cord-354050-kcn67stj	34	7	and	and	CC
cord-354050-kcn67stj	34	8	lysosomes	lysosome	NNS
cord-354050-kcn67stj	34	9	form	form	VBP
cord-354050-kcn67stj	34	10	hybrid	hybrid	NN
cord-354050-kcn67stj	34	11	organelles	organelle	NNS
cord-354050-kcn67stj	34	12	in	in	IN
cord-354050-kcn67stj	34	13	cells	cell	NNS
cord-354050-kcn67stj	34	14	and	and	CC
cord-354050-kcn67stj	34	15	are	be	VBP
cord-354050-kcn67stj	34	16	nearly	nearly	RB
cord-354050-kcn67stj	34	17	indistinguishable	indistinguishable	JJ
cord-354050-kcn67stj	34	18	by	by	IN
cord-354050-kcn67stj	34	19	conventional	conventional	JJ
cord-354050-kcn67stj	34	20	methods	method	NNS
cord-354050-kcn67stj	34	21	,	,	,
cord-354050-kcn67stj	34	22	and	and	CC
cord-354050-kcn67stj	34	23	hence	hence	RB
cord-354050-kcn67stj	34	24	the	the	DT
cord-354050-kcn67stj	34	25	subcellular	subcellular	JJ
cord-354050-kcn67stj	34	26	localization	localization	NN
cord-354050-kcn67stj	34	27	of	of	IN
cord-354050-kcn67stj	34	28	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	34	29	is	be	VBZ
cord-354050-kcn67stj	34	30	often	often	RB
cord-354050-kcn67stj	34	31	described	describe	VBN
cord-354050-kcn67stj	34	32	as	as	IN
cord-354050-kcn67stj	34	33	endolysosomal	endolysosomal	NNP
cord-354050-kcn67stj	34	34	.	.	.
cord-354050-kcn67stj	35	1	However	however	RB
cord-354050-kcn67stj	35	2	,	,	,
cord-354050-kcn67stj	35	3	some	some	DT
cord-354050-kcn67stj	35	4	of	of	IN
cord-354050-kcn67stj	35	5	the	the	DT
cord-354050-kcn67stj	35	6	overlap	overlap	NN
cord-354050-kcn67stj	35	7	with	with	IN
cord-354050-kcn67stj	35	8	lysosomes	lysosome	NNS
cord-354050-kcn67stj	35	9	must	must	MD
cord-354050-kcn67stj	35	10	be	be	VB
cord-354050-kcn67stj	35	11	attributed	attribute	VBN
cord-354050-kcn67stj	35	12	to	to	IN
cord-354050-kcn67stj	35	13	the	the	DT
cord-354050-kcn67stj	35	14	degradative	degradative	JJ
cord-354050-kcn67stj	35	15	pathway	pathway	NN
cord-354050-kcn67stj	35	16	controlling	control	VBG
cord-354050-kcn67stj	35	17	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	35	18	protein	protein	NN
cord-354050-kcn67stj	35	19	turnover	turnover	NN
cord-354050-kcn67stj	35	20	,	,	,
cord-354050-kcn67stj	35	21	which	which	WDT
cord-354050-kcn67stj	35	22	is	be	VBZ
cord-354050-kcn67stj	35	23	mediated	mediate	VBN
cord-354050-kcn67stj	35	24	by	by	IN
cord-354050-kcn67stj	35	25	the	the	DT
cord-354050-kcn67stj	35	26	E3	e3	NN
cord-354050-kcn67stj	35	27	ubiquitin	ubiquitin	NN
cord-354050-kcn67stj	35	28	ligase	ligase	NN
cord-354050-kcn67stj	36	1	NEDD4	NEDD4	NNP
cord-354050-kcn67stj	37	1	[	[	-LRB-
cord-354050-kcn67stj	37	2	19	19	CD
cord-354050-kcn67stj	37	3	]	]	-RRB-
cord-354050-kcn67stj	37	4	.	.	.
cord-354050-kcn67stj	38	1	Furthermore	furthermore	RB
cord-354050-kcn67stj	38	2	,	,	,
cord-354050-kcn67stj	38	3	recent	recent	JJ
cord-354050-kcn67stj	38	4	reports	report	NNS
cord-354050-kcn67stj	38	5	highlighting	highlight	VBG
cord-354050-kcn67stj	38	6	roles	role	NNS
cord-354050-kcn67stj	38	7	for	for	IN
cord-354050-kcn67stj	38	8	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	38	9	in	in	IN
cord-354050-kcn67stj	38	10	autophagy	autophagy	NN
cord-354050-kcn67stj	38	11	,	,	,
cord-354050-kcn67stj	38	12	a	a	DT
cord-354050-kcn67stj	38	13	catabolic	catabolic	JJ
cord-354050-kcn67stj	38	14	process	process	NN
cord-354050-kcn67stj	38	15	involving	involve	VBG
cord-354050-kcn67stj	38	16	the	the	DT
cord-354050-kcn67stj	38	17	degradation	degradation	NN
cord-354050-kcn67stj	38	18	of	of	IN
cord-354050-kcn67stj	38	19	cellular	cellular	JJ
cord-354050-kcn67stj	38	20	cargo	cargo	NN
cord-354050-kcn67stj	38	21	in	in	IN
cord-354050-kcn67stj	38	22	lysosomes	lysosome	NNS
cord-354050-kcn67stj	38	23	,	,	,
cord-354050-kcn67stj	38	24	may	may	MD
cord-354050-kcn67stj	38	25	explain	explain	VB
cord-354050-kcn67stj	38	26	the	the	DT
cord-354050-kcn67stj	38	27	apparent	apparent	JJ
cord-354050-kcn67stj	38	28	association	association	NN
cord-354050-kcn67stj	38	29	with	with	IN
cord-354050-kcn67stj	38	30	autophagosomes	autophagosomes	NNP
cord-354050-kcn67stj	38	31	[	[	-LRB-
cord-354050-kcn67stj	38	32	20	20	CD
cord-354050-kcn67stj	38	33	]	]	-RRB-
cord-354050-kcn67stj	38	34	.	.	.
cord-354050-kcn67stj	39	1	In	in	IN
cord-354050-kcn67stj	39	2	summary	summary	NN
cord-354050-kcn67stj	39	3	,	,	,
cord-354050-kcn67stj	39	4	while	while	IN
cord-354050-kcn67stj	39	5	endolysosomes	endolysosome	NNS
cord-354050-kcn67stj	39	6	appear	appear	VBP
cord-354050-kcn67stj	39	7	to	to	TO
cord-354050-kcn67stj	39	8	be	be	VB
cord-354050-kcn67stj	39	9	the	the	DT
cord-354050-kcn67stj	39	10	key	key	JJ
cord-354050-kcn67stj	39	11	compartment	compartment	NN
cord-354050-kcn67stj	39	12	whereby	whereby	WRB
cord-354050-kcn67stj	39	13	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	39	14	restricts	restrict	VBZ
cord-354050-kcn67stj	39	15	virus	virus	NN
cord-354050-kcn67stj	39	16	entry	entry	NN
cord-354050-kcn67stj	39	17	,	,	,
cord-354050-kcn67stj	39	18	its	-PRON-	PRP$
cord-354050-kcn67stj	39	19	detection	detection	NN
cord-354050-kcn67stj	39	20	in	in	IN
cord-354050-kcn67stj	39	21	other	other	JJ
cord-354050-kcn67stj	39	22	organelles	organelle	NNS
cord-354050-kcn67stj	39	23	may	may	MD
cord-354050-kcn67stj	39	24	be	be	VB
cord-354050-kcn67stj	39	25	indicative	indicative	JJ
cord-354050-kcn67stj	39	26	of	of	IN
cord-354050-kcn67stj	39	27	uncharacterized	uncharacterized	JJ
cord-354050-kcn67stj	39	28	cellular	cellular	JJ
cord-354050-kcn67stj	39	29	functions	function	NNS
cord-354050-kcn67stj	39	30	that	that	WDT
cord-354050-kcn67stj	39	31	are	be	VBP
cord-354050-kcn67stj	39	32	only	only	RB
cord-354050-kcn67stj	39	33	now	now	RB
cord-354050-kcn67stj	39	34	being	be	VBG
cord-354050-kcn67stj	39	35	investigated	investigate	VBN
cord-354050-kcn67stj	39	36	.	.	.
cord-354050-kcn67stj	40	1	As	as	IN
cord-354050-kcn67stj	40	2	residents	resident	NNS
cord-354050-kcn67stj	40	3	of	of	IN
cord-354050-kcn67stj	40	4	cellular	cellular	JJ
cord-354050-kcn67stj	40	5	membranes	membrane	NNS
cord-354050-kcn67stj	40	6	,	,	,
cord-354050-kcn67stj	40	7	an	an	DT
cord-354050-kcn67stj	40	8	attractive	attractive	JJ
cord-354050-kcn67stj	40	9	explanation	explanation	NN
cord-354050-kcn67stj	40	10	for	for	IN
cord-354050-kcn67stj	40	11	the	the	DT
cord-354050-kcn67stj	40	12	effects	effect	NNS
cord-354050-kcn67stj	40	13	of	of	IN
cord-354050-kcn67stj	40	14	IFITM	IFITM	NNP
cord-354050-kcn67stj	40	15	proteins	protein	NNS
cord-354050-kcn67stj	40	16	on	on	IN
cord-354050-kcn67stj	40	17	virus	virus	NN
cord-354050-kcn67stj	40	18	entry	entry	NN
cord-354050-kcn67stj	40	19	involves	involve	VBZ
cord-354050-kcn67stj	40	20	direct	direct	JJ
cord-354050-kcn67stj	40	21	modification	modification	NN
cord-354050-kcn67stj	40	22	of	of	IN
cord-354050-kcn67stj	40	23	membrane	membrane	NN
cord-354050-kcn67stj	40	24	rigidity	rigidity	NN
cord-354050-kcn67stj	40	25	and	and	CC
cord-354050-kcn67stj	40	26	curvature	curvature	NN
cord-354050-kcn67stj	40	27	,	,	,
cord-354050-kcn67stj	40	28	but	but	CC
cord-354050-kcn67stj	40	29	other	other	JJ
cord-354050-kcn67stj	40	30	indirect	indirect	JJ
cord-354050-kcn67stj	40	31	mechanisms	mechanism	NNS
cord-354050-kcn67stj	40	32	have	have	VBP
cord-354050-kcn67stj	40	33	also	also	RB
cord-354050-kcn67stj	40	34	been	be	VBN
cord-354050-kcn67stj	40	35	proposed	propose	VBN
cord-354050-kcn67stj	41	1	(	(	-LRB-
cord-354050-kcn67stj	41	2	Fig	Fig	NNP
cord-354050-kcn67stj	41	3	.	.	.
cord-354050-kcn67stj	41	4	1	1	CD
cord-354050-kcn67stj	41	5	membrane	membrane	NN
cord-354050-kcn67stj	41	6	proteins	protein	NNS
cord-354050-kcn67stj	41	7	can	can	MD
cord-354050-kcn67stj	41	8	alter	alter	VB
cord-354050-kcn67stj	41	9	the	the	DT
cord-354050-kcn67stj	41	10	shape	shape	NN
cord-354050-kcn67stj	41	11	and	and	CC
cord-354050-kcn67stj	41	12	fluidity	fluidity	NN
cord-354050-kcn67stj	41	13	of	of	IN
cord-354050-kcn67stj	41	14	lipid	lipid	NN
cord-354050-kcn67stj	41	15	bilayers	bilayer	NNS
cord-354050-kcn67stj	41	16	,	,	,
cord-354050-kcn67stj	41	17	and	and	CC
cord-354050-kcn67stj	41	18	furthermore	furthermore	RB
cord-354050-kcn67stj	41	19	,	,	,
cord-354050-kcn67stj	41	20	that	that	IN
cord-354050-kcn67stj	41	21	virus	virus	NN
cord-354050-kcn67stj	41	22	-	-	HYPH
cord-354050-kcn67stj	41	23	cell	cell	NN
cord-354050-kcn67stj	41	24	fusion	fusion	NN
cord-354050-kcn67stj	41	25	is	be	VBZ
cord-354050-kcn67stj	41	26	affected	affect	VBN
cord-354050-kcn67stj	41	27	by	by	IN
cord-354050-kcn67stj	41	28	these	these	DT
cord-354050-kcn67stj	41	29	factors	factor	NNS
cord-354050-kcn67stj	41	30	[	[	-LRB-
cord-354050-kcn67stj	41	31	21	21	CD
cord-354050-kcn67stj	41	32	]	]	-RRB-
cord-354050-kcn67stj	41	33	.	.	.
cord-354050-kcn67stj	42	1	Most	Most	JJS
cord-354050-kcn67stj	42	2	of	of	IN
cord-354050-kcn67stj	42	3	what	what	WP
cord-354050-kcn67stj	42	4	we	-PRON-	PRP
cord-354050-kcn67stj	42	5	know	know	VBP
cord-354050-kcn67stj	42	6	about	about	IN
cord-354050-kcn67stj	42	7	the	the	DT
cord-354050-kcn67stj	42	8	antiviral	antiviral	JJ
cord-354050-kcn67stj	42	9	activities	activity	NNS
cord-354050-kcn67stj	42	10	of	of	IN
cord-354050-kcn67stj	42	11	IFITM	IFITM	NNP
cord-354050-kcn67stj	42	12	proteins	protein	NNS
cord-354050-kcn67stj	42	13	results	result	NNS
cord-354050-kcn67stj	42	14	from	from	IN
cord-354050-kcn67stj	42	15	work	work	NN
cord-354050-kcn67stj	42	16	using	use	VBG
cord-354050-kcn67stj	42	17	IAV	IAV	NNP
cord-354050-kcn67stj	42	18	and	and	CC
cord-354050-kcn67stj	42	19	vesicular	vesicular	JJ
cord-354050-kcn67stj	42	20	stomatitis	stomatitis	NN
cord-354050-kcn67stj	42	21	virus	virus	NN
cord-354050-kcn67stj	42	22	(	(	-LRB-
cord-354050-kcn67stj	42	23	VSV	VSV	NNP
cord-354050-kcn67stj	42	24	)	)	-RRB-
cord-354050-kcn67stj	42	25	,	,	,
cord-354050-kcn67stj	42	26	which	which	WDT
cord-354050-kcn67stj	42	27	perform	perform	VBP
cord-354050-kcn67stj	42	28	pH	ph	NN
cord-354050-kcn67stj	42	29	-	-	HYPH
cord-354050-kcn67stj	42	30	dependent	dependent	JJ
cord-354050-kcn67stj	42	31	fusion	fusion	NN
cord-354050-kcn67stj	42	32	reactions	reaction	NNS
cord-354050-kcn67stj	42	33	in	in	IN
cord-354050-kcn67stj	42	34	endosomes	endosome	NNS
cord-354050-kcn67stj	42	35	to	to	TO
cord-354050-kcn67stj	42	36	gain	gain	VB
cord-354050-kcn67stj	42	37	access	access	NN
cord-354050-kcn67stj	42	38	to	to	IN
cord-354050-kcn67stj	42	39	the	the	DT
cord-354050-kcn67stj	42	40	cell	cell	NN
cord-354050-kcn67stj	42	41	interior	interior	NN
cord-354050-kcn67stj	42	42	[	[	-LRB-
cord-354050-kcn67stj	42	43	22	22	CD
cord-354050-kcn67stj	42	44	]	]	-RRB-
cord-354050-kcn67stj	42	45	.	.	.
cord-354050-kcn67stj	43	1	Early	early	JJ
cord-354050-kcn67stj	43	2	findings	finding	NNS
cord-354050-kcn67stj	43	3	using	use	VBG
cord-354050-kcn67stj	43	4	fluorescent	fluorescent	JJ
cord-354050-kcn67stj	43	5	microscopy	microscopy	NNS
cord-354050-kcn67stj	43	6	and	and	CC
cord-354050-kcn67stj	43	7	flow	flow	NN
cord-354050-kcn67stj	43	8	cytometry	cytometry	NN
cord-354050-kcn67stj	43	9	of	of	IN
cord-354050-kcn67stj	43	10	single	single	JJ
cord-354050-kcn67stj	43	11	cells	cell	NNS
cord-354050-kcn67stj	43	12	implicated	implicate	VBN
cord-354050-kcn67stj	43	13	IFITM3	ifitm3	PRP
cord-354050-kcn67stj	43	14	as	as	IN
cord-354050-kcn67stj	43	15	an	an	DT
cord-354050-kcn67stj	43	16	obstacle	obstacle	NN
cord-354050-kcn67stj	43	17	to	to	IN
cord-354050-kcn67stj	43	18	virus	virus	NN
cord-354050-kcn67stj	43	19	-	-	HYPH
cord-354050-kcn67stj	43	20	cell	cell	NN
cord-354050-kcn67stj	43	21	fusion	fusion	NN
cord-354050-kcn67stj	43	22	.	.	.
cord-354050-kcn67stj	44	1	When	when	WRB
cord-354050-kcn67stj	44	2	cells	cell	NNS
cord-354050-kcn67stj	44	3	overexpressing	overexpresse	VBG
cord-354050-kcn67stj	44	4	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	44	5	are	be	VBP
cord-354050-kcn67stj	44	6	challenged	challenge	VBN
cord-354050-kcn67stj	44	7	with	with	IN
cord-354050-kcn67stj	44	8	IAV	IAV	NNP
cord-354050-kcn67stj	44	9	,	,	,
cord-354050-kcn67stj	44	10	productive	productive	JJ
cord-354050-kcn67stj	44	11	infection	infection	NN
cord-354050-kcn67stj	44	12	is	be	VBZ
cord-354050-kcn67stj	44	13	inhibited	inhibit	VBN
cord-354050-kcn67stj	44	14	[	[	-LRB-
cord-354050-kcn67stj	44	15	8	8	CD
cord-354050-kcn67stj	44	16	]	]	-RRB-
cord-354050-kcn67stj	44	17	.	.	.
cord-354050-kcn67stj	45	1	Upon	upon	IN
cord-354050-kcn67stj	45	2	close	close	JJ
cord-354050-kcn67stj	45	3	examination	examination	NN
cord-354050-kcn67stj	45	4	,	,	,
cord-354050-kcn67stj	45	5	virions	virion	NNS
cord-354050-kcn67stj	45	6	undergo	undergo	VBP
cord-354050-kcn67stj	45	7	attachment	attachment	NN
cord-354050-kcn67stj	45	8	and	and	CC
cord-354050-kcn67stj	45	9	internalization	internalization	NN
cord-354050-kcn67stj	45	10	into	into	IN
cord-354050-kcn67stj	45	11	cells	cell	NNS
cord-354050-kcn67stj	45	12	before	before	IN
cord-354050-kcn67stj	45	13	becoming	become	VBG
cord-354050-kcn67stj	45	14	cleared	clear	VBN
cord-354050-kcn67stj	45	15	from	from	IN
cord-354050-kcn67stj	45	16	the	the	DT
cord-354050-kcn67stj	45	17	cell	cell	NN
cord-354050-kcn67stj	45	18	interior	interior	NN
cord-354050-kcn67stj	45	19	[	[	-LRB-
cord-354050-kcn67stj	45	20	9	9	CD
cord-354050-kcn67stj	45	21	]	]	-RRB-
cord-354050-kcn67stj	45	22	.	.	.
cord-354050-kcn67stj	46	1	Parallel	parallel	JJ
cord-354050-kcn67stj	46	2	experiments	experiment	NNS
cord-354050-kcn67stj	46	3	further	further	RB
cord-354050-kcn67stj	46	4	showed	show	VBD
cord-354050-kcn67stj	46	5	that	that	IN
cord-354050-kcn67stj	46	6	IFITM3	ifitm3	PRP
cord-354050-kcn67stj	46	7	may	may	MD
cord-354050-kcn67stj	46	8	expand	expand	VB
cord-354050-kcn67stj	46	9	the	the	DT
cord-354050-kcn67stj	46	10	size	size	NN
cord-354050-kcn67stj	46	11	and	and	CC
cord-354050-kcn67stj	46	12	acidity	acidity	NN
cord-354050-kcn67stj	46	13	of	of	IN
cord-354050-kcn67stj	46	14	the	the	DT
cord-354050-kcn67stj	46	15	endolysomal	endolysomal	NNP
cord-354050-kcn67stj	46	16	compartment	compartment	NN
cord-354050-kcn67stj	46	17	itself	-PRON-	PRP
cord-354050-kcn67stj	46	18	.	.	.
cord-354050-kcn67stj	47	1	In	in	IN
cord-354050-kcn67stj	47	2	effect	effect	NN
cord-354050-kcn67stj	47	3	,	,	,
cord-354050-kcn67stj	47	4	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	47	5	appears	appear	VBZ
cord-354050-kcn67stj	47	6	to	to	TO
cord-354050-kcn67stj	47	7	trap	trap	VB
cord-354050-kcn67stj	47	8	endocytosed	endocytose	VBN
cord-354050-kcn67stj	47	9	virions	virion	NNS
cord-354050-kcn67stj	47	10	inside	inside	IN
cord-354050-kcn67stj	47	11	vesicles	vesicle	NNS
cord-354050-kcn67stj	47	12	slated	slate	VBN
cord-354050-kcn67stj	47	13	for	for	IN
cord-354050-kcn67stj	47	14	destruction	destruction	NN
cord-354050-kcn67stj	47	15	in	in	IN
cord-354050-kcn67stj	47	16	a	a	DT
cord-354050-kcn67stj	47	17	degradative	degradative	JJ
cord-354050-kcn67stj	47	18	pathway	pathway	NN
cord-354050-kcn67stj	47	19	[	[	-LRB-
cord-354050-kcn67stj	47	20	6	6	CD
cord-354050-kcn67stj	47	21	]	]	-RRB-
cord-354050-kcn67stj	47	22	.	.	.
cord-354050-kcn67stj	48	1	It	-PRON-	PRP
cord-354050-kcn67stj	48	2	remains	remain	VBZ
cord-354050-kcn67stj	48	3	to	to	TO
cord-354050-kcn67stj	48	4	be	be	VB
cord-354050-kcn67stj	48	5	determined	determine	VBN
cord-354050-kcn67stj	48	6	whether	whether	IN
cord-354050-kcn67stj	48	7	IFITM3-containing	IFITM3-containing	NNP
cord-354050-kcn67stj	48	8	structures	structure	NNS
cord-354050-kcn67stj	48	9	represent	represent	VBP
cord-354050-kcn67stj	48	10	a	a	DT
cord-354050-kcn67stj	48	11	distinct	distinct	JJ
cord-354050-kcn67stj	48	12	,	,	,
cord-354050-kcn67stj	48	13	hostile	hostile	JJ
cord-354050-kcn67stj	48	14	subset	subset	NN
cord-354050-kcn67stj	48	15	of	of	IN
cord-354050-kcn67stj	48	16	endolysosomes	endolysosome	NNS
cord-354050-kcn67stj	48	17	that	that	WDT
cord-354050-kcn67stj	48	18	are	be	VBP
cord-354050-kcn67stj	48	19	not	not	RB
cord-354050-kcn67stj	48	20	conducive	conducive	JJ
cord-354050-kcn67stj	48	21	to	to	IN
cord-354050-kcn67stj	48	22	virus	virus	NN
cord-354050-kcn67stj	48	23	-	-	HYPH
cord-354050-kcn67stj	48	24	cell	cell	NN
cord-354050-kcn67stj	48	25	fusion	fusion	NN
cord-354050-kcn67stj	48	26	.	.	.
cord-354050-kcn67stj	49	1	Indeed	indeed	RB
cord-354050-kcn67stj	49	2	,	,	,
cord-354050-kcn67stj	49	3	an	an	DT
cord-354050-kcn67stj	49	4	article	article	NN
cord-354050-kcn67stj	49	5	reported	report	VBD
cord-354050-kcn67stj	49	6	that	that	IN
cord-354050-kcn67stj	49	7	IAV	IAV	NNP
cord-354050-kcn67stj	49	8	sensitivity	sensitivity	NN
cord-354050-kcn67stj	49	9	to	to	IN
cord-354050-kcn67stj	49	10	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	49	11	is	be	VBZ
cord-354050-kcn67stj	49	12	determined	determine	VBN
cord-354050-kcn67stj	49	13	by	by	IN
cord-354050-kcn67stj	49	14	the	the	DT
cord-354050-kcn67stj	49	15	acidic	acidic	JJ
cord-354050-kcn67stj	49	16	threshold	threshold	NN
cord-354050-kcn67stj	49	17	at	at	IN
cord-354050-kcn67stj	49	18	which	which	WDT
cord-354050-kcn67stj	49	19	viral	viral	JJ
cord-354050-kcn67stj	49	20	hemagglutinin	hemagglutinin	NN
cord-354050-kcn67stj	49	21	(	(	-LRB-
cord-354050-kcn67stj	49	22	HA	HA	NNP
cord-354050-kcn67stj	49	23	)	)	-RRB-
cord-354050-kcn67stj	49	24	triggers	trigger	VBZ
cord-354050-kcn67stj	49	25	virus	virus	NN
cord-354050-kcn67stj	49	26	-	-	HYPH
cord-354050-kcn67stj	49	27	cell	cell	NN
cord-354050-kcn67stj	49	28	fusion	fusion	NN
cord-354050-kcn67stj	49	29	in	in	IN
cord-354050-kcn67stj	49	30	endosomes	endosome	NNS
cord-354050-kcn67stj	49	31	.	.	.
cord-354050-kcn67stj	50	1	That	that	RB
cord-354050-kcn67stj	50	2	is	is	RB
cord-354050-kcn67stj	50	3	,	,	,
cord-354050-kcn67stj	50	4	HA	HA	NNP
cord-354050-kcn67stj	50	5	variants	variant	NNS
cord-354050-kcn67stj	50	6	which	which	WDT
cord-354050-kcn67stj	50	7	drive	drive	VBP
cord-354050-kcn67stj	50	8	fusion	fusion	NN
cord-354050-kcn67stj	50	9	at	at	IN
cord-354050-kcn67stj	50	10	higher	high	JJR
cord-354050-kcn67stj	50	11	pH	pH	NNP
cord-354050-kcn67stj	50	12	(	(	-LRB-
cord-354050-kcn67stj	50	13	less	less	RBR
cord-354050-kcn67stj	50	14	acidic	acidic	JJ
cord-354050-kcn67stj	50	15	)	)	-RRB-
cord-354050-kcn67stj	50	16	are	be	VBP
cord-354050-kcn67stj	50	17	more	more	RBR
cord-354050-kcn67stj	50	18	resistant	resistant	JJ
cord-354050-kcn67stj	50	19	to	to	IN
cord-354050-kcn67stj	50	20	the	the	DT
cord-354050-kcn67stj	50	21	block	block	NN
cord-354050-kcn67stj	50	22	by	by	IN
cord-354050-kcn67stj	50	23	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	50	24	,	,	,
cord-354050-kcn67stj	50	25	suggesting	suggest	VBG
cord-354050-kcn67stj	50	26	that	that	IN
cord-354050-kcn67stj	50	27	evasion	evasion	NN
cord-354050-kcn67stj	50	28	of	of	IN
cord-354050-kcn67stj	50	29	more	more	RBR
cord-354050-kcn67stj	50	30	acidic	acidic	JJ
cord-354050-kcn67stj	50	31	,	,	,
cord-354050-kcn67stj	50	32	late	late	JJ
cord-354050-kcn67stj	50	33	endosomes	endosome	NNS
cord-354050-kcn67stj	50	34	(	(	-LRB-
cord-354050-kcn67stj	50	35	where	where	WRB
cord-354050-kcn67stj	50	36	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	50	37	resides	reside	NNS
cord-354050-kcn67stj	50	38	in	in	IN
cord-354050-kcn67stj	50	39	most	most	JJS
cord-354050-kcn67stj	50	40	cell	cell	NN
cord-354050-kcn67stj	50	41	types	type	NNS
cord-354050-kcn67stj	50	42	)	)	-RRB-
cord-354050-kcn67stj	50	43	enables	enable	VBZ
cord-354050-kcn67stj	50	44	infection	infection	NN
cord-354050-kcn67stj	50	45	[	[	-LRB-
cord-354050-kcn67stj	50	46	23	23	CD
cord-354050-kcn67stj	50	47	]	]	-RRB-
cord-354050-kcn67stj	50	48	.	.	.
cord-354050-kcn67stj	51	1	This	this	DT
cord-354050-kcn67stj	51	2	assertion	assertion	NN
cord-354050-kcn67stj	51	3	is	be	VBZ
cord-354050-kcn67stj	51	4	supported	support	VBN
cord-354050-kcn67stj	51	5	further	further	RB
cord-354050-kcn67stj	51	6	by	by	IN
cord-354050-kcn67stj	51	7	the	the	DT
cord-354050-kcn67stj	51	8	observation	observation	NN
cord-354050-kcn67stj	51	9	that	that	WDT
cord-354050-kcn67stj	51	10	VSV	VSV	NNP
cord-354050-kcn67stj	51	11	infection	infection	NN
cord-354050-kcn67stj	51	12	,	,	,
cord-354050-kcn67stj	51	13	which	which	WDT
cord-354050-kcn67stj	51	14	requires	require	VBZ
cord-354050-kcn67stj	51	15	virus	virus	NN
cord-354050-kcn67stj	51	16	-	-	HYPH
cord-354050-kcn67stj	51	17	cell	cell	NN
cord-354050-kcn67stj	51	18	fusion	fusion	NN
cord-354050-kcn67stj	51	19	in	in	IN
cord-354050-kcn67stj	51	20	early	early	JJ
cord-354050-kcn67stj	51	21	endosomes	endosome	NNS
cord-354050-kcn67stj	51	22	,	,	,
cord-354050-kcn67stj	51	23	is	be	VBZ
cord-354050-kcn67stj	51	24	less	less	RBR
cord-354050-kcn67stj	51	25	affected	affect	VBN
cord-354050-kcn67stj	51	26	by	by	IN
cord-354050-kcn67stj	51	27	the	the	DT
cord-354050-kcn67stj	51	28	presence	presence	NN
cord-354050-kcn67stj	51	29	of	of	IN
cord-354050-kcn67stj	51	30	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	51	31	[	[	-LRB-
cord-354050-kcn67stj	51	32	8	8	CD
cord-354050-kcn67stj	51	33	,	,	,
cord-354050-kcn67stj	51	34	22	22	CD
cord-354050-kcn67stj	51	35	,	,	,
cord-354050-kcn67stj	51	36	24	24	CD
cord-354050-kcn67stj	51	37	]	]	-RRB-
cord-354050-kcn67stj	51	38	.	.	.
cord-354050-kcn67stj	52	1	The	the	DT
cord-354050-kcn67stj	52	2	effects	effect	NNS
cord-354050-kcn67stj	52	3	of	of	IN
cord-354050-kcn67stj	52	4	IFITM	IFITM	NNP
cord-354050-kcn67stj	52	5	proteins	protein	NNS
cord-354050-kcn67stj	52	6	on	on	IN
cord-354050-kcn67stj	52	7	the	the	DT
cord-354050-kcn67stj	52	8	makeup	makeup	NN
cord-354050-kcn67stj	52	9	of	of	IN
cord-354050-kcn67stj	52	10	the	the	DT
cord-354050-kcn67stj	52	11	cell	cell	NN
cord-354050-kcn67stj	52	12	interior	interior	NN
cord-354050-kcn67stj	52	13	may	may	MD
cord-354050-kcn67stj	52	14	present	present	VB
cord-354050-kcn67stj	52	15	important	important	JJ
cord-354050-kcn67stj	52	16	clues	clue	NNS
cord-354050-kcn67stj	52	17	about	about	IN
cord-354050-kcn67stj	52	18	its	-PRON-	PRP$
cord-354050-kcn67stj	52	19	principal	principal	JJ
cord-354050-kcn67stj	52	20	mechanism	mechanism	NN
cord-354050-kcn67stj	52	21	of	of	IN
cord-354050-kcn67stj	52	22	action	action	NN
cord-354050-kcn67stj	52	23	[	[	-LRB-
cord-354050-kcn67stj	52	24	9	9	CD
cord-354050-kcn67stj	52	25	]	]	-RRB-
cord-354050-kcn67stj	52	26	.	.	.
cord-354050-kcn67stj	53	1	Simple	simple	JJ
cord-354050-kcn67stj	53	2	experiments	experiment	NNS
cord-354050-kcn67stj	53	3	examining	examine	VBG
cord-354050-kcn67stj	53	4	cell	cell	NN
cord-354050-kcn67stj	53	5	-	-	HYPH
cord-354050-kcn67stj	53	6	cell	cell	NN
cord-354050-kcn67stj	53	7	fusion	fusion	NN
cord-354050-kcn67stj	53	8	,	,	,
cord-354050-kcn67stj	53	9	in	in	IN
cord-354050-kcn67stj	53	10	which	which	WDT
cord-354050-kcn67stj	53	11	IFITM	IFITM	NNP
cord-354050-kcn67stj	53	12	proteins	protein	NNS
cord-354050-kcn67stj	53	13	and	and	CC
cord-354050-kcn67stj	53	14	viral	viral	JJ
cord-354050-kcn67stj	53	15	envelope	envelope	NN
cord-354050-kcn67stj	53	16	proteins	protein	NNS
cord-354050-kcn67stj	53	17	are	be	VBP
cord-354050-kcn67stj	53	18	co	co	VBN
cord-354050-kcn67stj	53	19	-	-	VBN
cord-354050-kcn67stj	53	20	expressed	express	VBN
cord-354050-kcn67stj	53	21	,	,	,
cord-354050-kcn67stj	53	22	have	have	VBP
cord-354050-kcn67stj	53	23	been	be	VBN
cord-354050-kcn67stj	53	24	instrumental	instrumental	JJ
cord-354050-kcn67stj	53	25	in	in	IN
cord-354050-kcn67stj	53	26	testing	test	VBG
cord-354050-kcn67stj	53	27	different	different	JJ
cord-354050-kcn67stj	53	28	mechanistic	mechanistic	JJ
cord-354050-kcn67stj	53	29	possibilities	possibility	NNS
cord-354050-kcn67stj	53	30	.	.	.
cord-354050-kcn67stj	54	1	Initial	initial	JJ
cord-354050-kcn67stj	54	2	reports	report	NNS
cord-354050-kcn67stj	54	3	showed	show	VBD
cord-354050-kcn67stj	54	4	that	that	IN
cord-354050-kcn67stj	54	5	IFITM	IFITM	NNP
cord-354050-kcn67stj	54	6	members	member	NNS
cord-354050-kcn67stj	54	7	inhibit	inhibit	VBP
cord-354050-kcn67stj	54	8	cell	cell	NN
cord-354050-kcn67stj	54	9	-	-	HYPH
cord-354050-kcn67stj	54	10	cell	cell	NN
cord-354050-kcn67stj	54	11	fusion	fusion	NN
cord-354050-kcn67stj	54	12	mediated	mediate	VBN
cord-354050-kcn67stj	54	13	by	by	IN
cord-354050-kcn67stj	54	14	three	three	CD
cord-354050-kcn67stj	54	15	classes	class	NNS
cord-354050-kcn67stj	54	16	of	of	IN
cord-354050-kcn67stj	54	17	viral	viral	JJ
cord-354050-kcn67stj	54	18	fusion	fusion	NN
cord-354050-kcn67stj	54	19	proteins	protein	NNS
cord-354050-kcn67stj	54	20	(	(	-LRB-
cord-354050-kcn67stj	54	21	some	some	DT
cord-354050-kcn67stj	54	22	more	more	JJR
cord-354050-kcn67stj	54	23	than	than	IN
cord-354050-kcn67stj	54	24	others	other	NNS
cord-354050-kcn67stj	54	25	)	)	-RRB-
cord-354050-kcn67stj	54	26	in	in	IN
cord-354050-kcn67stj	54	27	a	a	DT
cord-354050-kcn67stj	54	28	way	way	NN
cord-354050-kcn67stj	54	29	that	that	WDT
cord-354050-kcn67stj	54	30	did	do	VBD
cord-354050-kcn67stj	54	31	not	not	RB
cord-354050-kcn67stj	54	32	affect	affect	VB
cord-354050-kcn67stj	54	33	envelope	envelope	NN
cord-354050-kcn67stj	54	34	expression	expression	NN
cord-354050-kcn67stj	54	35	itself	-PRON-	PRP
cord-354050-kcn67stj	54	36	[	[	-LRB-
cord-354050-kcn67stj	54	37	25	25	CD
cord-354050-kcn67stj	54	38	]	]	-RRB-
cord-354050-kcn67stj	54	39	.	.	.
cord-354050-kcn67stj	55	1	This	this	DT
cord-354050-kcn67stj	55	2	finding	finding	NN
cord-354050-kcn67stj	55	3	suggests	suggest	VBZ
cord-354050-kcn67stj	55	4	that	that	IN
cord-354050-kcn67stj	55	5	IFITM	IFITM	NNP
cord-354050-kcn67stj	55	6	proteins	protein	NNS
cord-354050-kcn67stj	55	7	may	may	MD
cord-354050-kcn67stj	55	8	affect	affect	VB
cord-354050-kcn67stj	55	9	the	the	DT
cord-354050-kcn67stj	55	10	physical	physical	JJ
cord-354050-kcn67stj	55	11	aspects	aspect	NNS
cord-354050-kcn67stj	55	12	of	of	IN
cord-354050-kcn67stj	55	13	membranes	membrane	NNS
cord-354050-kcn67stj	55	14	in	in	IN
cord-354050-kcn67stj	55	15	a	a	DT
cord-354050-kcn67stj	55	16	way	way	NN
cord-354050-kcn67stj	55	17	that	that	WDT
cord-354050-kcn67stj	55	18	prevents	prevent	VBZ
cord-354050-kcn67stj	55	19	fusion	fusion	NN
cord-354050-kcn67stj	55	20	by	by	IN
cord-354050-kcn67stj	55	21	diverse	diverse	JJ
cord-354050-kcn67stj	55	22	viral	viral	JJ
cord-354050-kcn67stj	55	23	fusion	fusion	NN
cord-354050-kcn67stj	55	24	proteins	protein	NNS
cord-354050-kcn67stj	55	25	.	.	.
cord-354050-kcn67stj	56	1	While	while	IN
cord-354050-kcn67stj	56	2	informative	informative	JJ
cord-354050-kcn67stj	56	3	,	,	,
cord-354050-kcn67stj	56	4	an	an	DT
cord-354050-kcn67stj	56	5	important	important	JJ
cord-354050-kcn67stj	56	6	caveat	caveat	NN
cord-354050-kcn67stj	56	7	is	be	VBZ
cord-354050-kcn67stj	56	8	that	that	IN
cord-354050-kcn67stj	56	9	cell	cell	NN
cord-354050-kcn67stj	56	10	-	-	HYPH
cord-354050-kcn67stj	56	11	cell	cell	NN
cord-354050-kcn67stj	56	12	fusion	fusion	NN
cord-354050-kcn67stj	56	13	experiments	experiment	NNS
cord-354050-kcn67stj	56	14	in	in	IN
cord-354050-kcn67stj	56	15	tissue	tissue	NN
cord-354050-kcn67stj	56	16	culture	culture	NN
cord-354050-kcn67stj	56	17	do	do	VBP
cord-354050-kcn67stj	56	18	not	not	RB
cord-354050-kcn67stj	56	19	accurately	accurately	RB
cord-354050-kcn67stj	56	20	reproduce	reproduce	VB
cord-354050-kcn67stj	56	21	the	the	DT
cord-354050-kcn67stj	56	22	true	true	JJ
cord-354050-kcn67stj	56	23	nature	nature	NN
cord-354050-kcn67stj	56	24	of	of	IN
cord-354050-kcn67stj	56	25	virus	virus	NN
cord-354050-kcn67stj	56	26	-	-	HYPH
cord-354050-kcn67stj	56	27	cell	cell	NN
cord-354050-kcn67stj	56	28	encounters	encounter	NNS
cord-354050-kcn67stj	56	29	,	,	,
cord-354050-kcn67stj	56	30	since	since	IN
cord-354050-kcn67stj	56	31	IFITM	IFITM	NNP
cord-354050-kcn67stj	56	32	and	and	CC
cord-354050-kcn67stj	56	33	viral	viral	JJ
cord-354050-kcn67stj	56	34	fusion	fusion	NN
cord-354050-kcn67stj	56	35	proteins	protein	NNS
cord-354050-kcn67stj	56	36	may	may	MD
cord-354050-kcn67stj	56	37	not	not	RB
cord-354050-kcn67stj	56	38	be	be	VB
cord-354050-kcn67stj	56	39	expressed	express	VBN
cord-354050-kcn67stj	56	40	at	at	IN
cord-354050-kcn67stj	56	41	physiologically	physiologically	RB
cord-354050-kcn67stj	56	42	relevant	relevant	JJ
cord-354050-kcn67stj	56	43	levels	level	NNS
cord-354050-kcn67stj	56	44	or	or	CC
cord-354050-kcn67stj	56	45	at	at	IN
cord-354050-kcn67stj	56	46	correct	correct	JJ
cord-354050-kcn67stj	56	47	subcellular	subcellular	JJ
cord-354050-kcn67stj	56	48	sites	site	NNS
cord-354050-kcn67stj	56	49	.	.	.
cord-354050-kcn67stj	57	1	Attempts	attempt	NNS
cord-354050-kcn67stj	57	2	at	at	IN
cord-354050-kcn67stj	57	3	identifying	identify	VBG
cord-354050-kcn67stj	57	4	the	the	DT
cord-354050-kcn67stj	57	5	precise	precise	JJ
cord-354050-kcn67stj	57	6	step	step	NN
cord-354050-kcn67stj	57	7	of	of	IN
cord-354050-kcn67stj	57	8	the	the	DT
cord-354050-kcn67stj	57	9	fusion	fusion	NN
cord-354050-kcn67stj	57	10	sequence	sequence	NN
cord-354050-kcn67stj	57	11	inhibited	inhibit	VBN
cord-354050-kcn67stj	57	12	by	by	IN
cord-354050-kcn67stj	57	13	IFITM	IFITM	NNP
cord-354050-kcn67stj	57	14	suggested	suggest	VBD
cord-354050-kcn67stj	57	15	a	a	DT
cord-354050-kcn67stj	57	16	block	block	NN
cord-354050-kcn67stj	57	17	prior	prior	RB
cord-354050-kcn67stj	57	18	to	to	IN
cord-354050-kcn67stj	57	19	hemifusion	hemifusion	NN
cord-354050-kcn67stj	57	20	,	,	,
cord-354050-kcn67stj	57	21	the	the	DT
cord-354050-kcn67stj	57	22	point	point	NN
cord-354050-kcn67stj	57	23	at	at	IN
cord-354050-kcn67stj	57	24	which	which	WDT
cord-354050-kcn67stj	57	25	lipid	lipid	NN
cord-354050-kcn67stj	57	26	mixing	mixing	NN
cord-354050-kcn67stj	57	27	begins	begin	VBZ
cord-354050-kcn67stj	57	28	between	between	IN
cord-354050-kcn67stj	57	29	leaflets	leaflet	NNS
cord-354050-kcn67stj	57	30	of	of	IN
cord-354050-kcn67stj	57	31	two	two	CD
cord-354050-kcn67stj	57	32	juxtaposed	juxtaposed	JJ
cord-354050-kcn67stj	57	33	membranes	membrane	NNS
cord-354050-kcn67stj	57	34	[	[	-LRB-
cord-354050-kcn67stj	57	35	25	25	CD
cord-354050-kcn67stj	57	36	]	]	-RRB-
cord-354050-kcn67stj	57	37	.	.	.
cord-354050-kcn67stj	58	1	However	however	RB
cord-354050-kcn67stj	58	2	,	,	,
cord-354050-kcn67stj	58	3	other	other	JJ
cord-354050-kcn67stj	58	4	techniques	technique	NNS
cord-354050-kcn67stj	58	5	including	include	VBG
cord-354050-kcn67stj	58	6	virus	virus	NN
cord-354050-kcn67stj	58	7	particle	particle	NN
cord-354050-kcn67stj	58	8	tracking	tracking	NN
cord-354050-kcn67stj	58	9	detected	detect	VBD
cord-354050-kcn67stj	58	10	lipid	lipid	NN
cord-354050-kcn67stj	58	11	mixing	mix	VBG
cord-354050-kcn67stj	58	12	between	between	IN
cord-354050-kcn67stj	58	13	cell	cell	NN
cord-354050-kcn67stj	58	14	and	and	CC
cord-354050-kcn67stj	58	15	virus	virus	NN
cord-354050-kcn67stj	58	16	in	in	IN
cord-354050-kcn67stj	58	17	the	the	DT
cord-354050-kcn67stj	58	18	presence	presence	NN
cord-354050-kcn67stj	58	19	of	of	IN
cord-354050-kcn67stj	58	20	IFITM	IFITM	NNP
cord-354050-kcn67stj	58	21	but	but	CC
cord-354050-kcn67stj	58	22	no	no	DT
cord-354050-kcn67stj	58	23	viral	viral	JJ
cord-354050-kcn67stj	58	24	escape	escape	NN
cord-354050-kcn67stj	58	25	into	into	IN
cord-354050-kcn67stj	58	26	the	the	DT
cord-354050-kcn67stj	58	27	cytoplasm	cytoplasm	NN
cord-354050-kcn67stj	58	28	,	,	,
cord-354050-kcn67stj	58	29	suggesting	suggest	VBG
cord-354050-kcn67stj	58	30	that	that	IN
cord-354050-kcn67stj	58	31	dilation	dilation	NN
cord-354050-kcn67stj	58	32	of	of	IN
cord-354050-kcn67stj	58	33	the	the	DT
cord-354050-kcn67stj	58	34	fusion	fusion	NN
cord-354050-kcn67stj	58	35	pore	pore	NN
cord-354050-kcn67stj	58	36	is	be	VBZ
cord-354050-kcn67stj	58	37	restricted	restrict	VBN
cord-354050-kcn67stj	58	38	[	[	-LRB-
cord-354050-kcn67stj	58	39	26	26	CD
cord-354050-kcn67stj	58	40	]	]	-RRB-
cord-354050-kcn67stj	58	41	.	.	.
cord-354050-kcn67stj	59	1	The	the	DT
cord-354050-kcn67stj	59	2	basis	basis	NN
cord-354050-kcn67stj	59	3	for	for	IN
cord-354050-kcn67stj	59	4	these	these	DT
cord-354050-kcn67stj	59	5	observations	observation	NNS
cord-354050-kcn67stj	59	6	may	may	MD
cord-354050-kcn67stj	59	7	lie	lie	VB
cord-354050-kcn67stj	59	8	with	with	IN
cord-354050-kcn67stj	59	9	increased	increase	VBN
cord-354050-kcn67stj	59	10	lipid	lipid	NN
cord-354050-kcn67stj	59	11	density	density	NN
cord-354050-kcn67stj	59	12	or	or	CC
cord-354050-kcn67stj	59	13	increased	increase	VBN
cord-354050-kcn67stj	59	14	positive	positive	JJ
cord-354050-kcn67stj	59	15	curvature	curvature	NN
cord-354050-kcn67stj	59	16	of	of	IN
cord-354050-kcn67stj	59	17	IFITM	IFITM	NNP
cord-354050-kcn67stj	59	18	-	-	HYPH
cord-354050-kcn67stj	59	19	containing	contain	VBG
cord-354050-kcn67stj	59	20	membranes	membrane	NNS
cord-354050-kcn67stj	59	21	[	[	-LRB-
cord-354050-kcn67stj	59	22	25	25	CD
cord-354050-kcn67stj	59	23	]	]	-RRB-
cord-354050-kcn67stj	59	24	.	.	.
cord-354050-kcn67stj	60	1	Another	another	DT
cord-354050-kcn67stj	60	2	piece	piece	NN
cord-354050-kcn67stj	60	3	of	of	IN
cord-354050-kcn67stj	60	4	evidence	evidence	NN
cord-354050-kcn67stj	60	5	in	in	IN
cord-354050-kcn67stj	60	6	support	support	NN
cord-354050-kcn67stj	60	7	of	of	IN
cord-354050-kcn67stj	60	8	IFITM	IFITM	NNP
cord-354050-kcn67stj	60	9	proteins	protein	NNS
cord-354050-kcn67stj	60	10	as	as	IN
cord-354050-kcn67stj	60	11	membrane	membrane	NN
cord-354050-kcn67stj	60	12	remodelers	remodeler	NNS
cord-354050-kcn67stj	60	13	is	be	VBZ
cord-354050-kcn67stj	60	14	the	the	DT
cord-354050-kcn67stj	60	15	finding	finding	NN
cord-354050-kcn67stj	60	16	that	that	IN
cord-354050-kcn67stj	60	17	amphotericin	amphotericin	NNS
cord-354050-kcn67stj	60	18	B	b	NN
cord-354050-kcn67stj	60	19	,	,	,
cord-354050-kcn67stj	60	20	an	an	DT
cord-354050-kcn67stj	60	21	antifungal	antifungal	JJ
cord-354050-kcn67stj	60	22	compound	compound	NN
cord-354050-kcn67stj	60	23	known	know	VBN
cord-354050-kcn67stj	60	24	to	to	TO
cord-354050-kcn67stj	60	25	enhance	enhance	VB
cord-354050-kcn67stj	60	26	membrane	membrane	NN
cord-354050-kcn67stj	60	27	fluidity	fluidity	NN
cord-354050-kcn67stj	60	28	,	,	,
cord-354050-kcn67stj	60	29	counteracts	counteract	VBZ
cord-354050-kcn67stj	60	30	the	the	DT
cord-354050-kcn67stj	60	31	activity	activity	NN
cord-354050-kcn67stj	60	32	of	of	IN
cord-354050-kcn67stj	60	33	IFITM3	ifitm3	PRP
cord-354050-kcn67stj	60	34	to	to	TO
cord-354050-kcn67stj	60	35	render	render	VB
cord-354050-kcn67stj	60	36	cells	cell	NNS
cord-354050-kcn67stj	60	37	permissive	permissive	JJ
cord-354050-kcn67stj	60	38	to	to	IN
cord-354050-kcn67stj	60	39	infection	infection	NN
cord-354050-kcn67stj	60	40	[	[	-LRB-
cord-354050-kcn67stj	60	41	27	27	CD
cord-354050-kcn67stj	60	42	]	]	-RRB-
cord-354050-kcn67stj	60	43	.	.	.
cord-354050-kcn67stj	61	1	Furthermore	furthermore	RB
cord-354050-kcn67stj	61	2	,	,	,
cord-354050-kcn67stj	61	3	the	the	DT
cord-354050-kcn67stj	61	4	discovery	discovery	NN
cord-354050-kcn67stj	61	5	of	of	IN
cord-354050-kcn67stj	61	6	an	an	DT
cord-354050-kcn67stj	61	7	amphipathic	amphipathic	JJ
cord-354050-kcn67stj	61	8	helix	helix	NN
cord-354050-kcn67stj	61	9	within	within	IN
cord-354050-kcn67stj	61	10	the	the	DT
cord-354050-kcn67stj	61	11	first	first	JJ
cord-354050-kcn67stj	61	12	hydrophobic	hydrophobic	JJ
cord-354050-kcn67stj	61	13	domain	domain	NN
cord-354050-kcn67stj	61	14	of	of	IN
cord-354050-kcn67stj	61	15	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	61	16	was	be	VBD
cord-354050-kcn67stj	61	17	found	find	VBN
cord-354050-kcn67stj	61	18	to	to	TO
cord-354050-kcn67stj	61	19	be	be	VB
cord-354050-kcn67stj	61	20	crucial	crucial	JJ
cord-354050-kcn67stj	61	21	to	to	IN
cord-354050-kcn67stj	61	22	the	the	DT
cord-354050-kcn67stj	61	23	inhibition	inhibition	NN
cord-354050-kcn67stj	61	24	of	of	IN
cord-354050-kcn67stj	61	25	virus	virus	NN
cord-354050-kcn67stj	61	26	entry	entry	NN
cord-354050-kcn67stj	61	27	[	[	-LRB-
cord-354050-kcn67stj	61	28	14	14	CD
cord-354050-kcn67stj	61	29	]	]	-RRB-
cord-354050-kcn67stj	61	30	.	.	.
cord-354050-kcn67stj	62	1	This	this	DT
cord-354050-kcn67stj	62	2	previously	previously	RB
cord-354050-kcn67stj	62	3	unappreciated	unappreciated	JJ
cord-354050-kcn67stj	62	4	structure	structure	NN
cord-354050-kcn67stj	62	5	is	be	VBZ
cord-354050-kcn67stj	62	6	positioned	position	VBN
cord-354050-kcn67stj	62	7	adjacent	adjacent	JJ
cord-354050-kcn67stj	62	8	to	to	IN
cord-354050-kcn67stj	62	9	palmitoylated	palmitoylate	VBN
cord-354050-kcn67stj	62	10	cysteine	cysteine	NN
cord-354050-kcn67stj	62	11	residues	residue	NNS
cord-354050-kcn67stj	62	12	involved	involve	VBN
cord-354050-kcn67stj	62	13	in	in	IN
cord-354050-kcn67stj	62	14	membrane	membrane	NN
cord-354050-kcn67stj	62	15	targeting	targeting	NN
cord-354050-kcn67stj	62	16	and	and	CC
cord-354050-kcn67stj	62	17	is	be	VBZ
cord-354050-kcn67stj	62	18	also	also	RB
cord-354050-kcn67stj	62	19	important	important	JJ
cord-354050-kcn67stj	62	20	for	for	IN
cord-354050-kcn67stj	62	21	the	the	DT
cord-354050-kcn67stj	62	22	inhibition	inhibition	NN
cord-354050-kcn67stj	62	23	of	of	IN
cord-354050-kcn67stj	62	24	cell	cell	NN
cord-354050-kcn67stj	62	25	-	-	HYPH
cord-354050-kcn67stj	62	26	cell	cell	NN
cord-354050-kcn67stj	62	27	fusion	fusion	NN
cord-354050-kcn67stj	62	28	.	.	.
cord-354050-kcn67stj	63	1	Based	base	VBN
cord-354050-kcn67stj	63	2	on	on	IN
cord-354050-kcn67stj	63	3	previously	previously	RB
cord-354050-kcn67stj	63	4	recognized	recognize	VBN
cord-354050-kcn67stj	63	5	functions	function	NNS
cord-354050-kcn67stj	63	6	of	of	IN
cord-354050-kcn67stj	63	7	other	other	JJ
cord-354050-kcn67stj	63	8	proteins	protein	NNS
cord-354050-kcn67stj	63	9	endowed	endow	VBN
cord-354050-kcn67stj	63	10	with	with	IN
cord-354050-kcn67stj	63	11	an	an	DT
cord-354050-kcn67stj	63	12	amphipathic	amphipathic	JJ
cord-354050-kcn67stj	63	13	helix	helix	NN
cord-354050-kcn67stj	63	14	,	,	,
cord-354050-kcn67stj	63	15	IFITM	IFITM	NNP
cord-354050-kcn67stj	63	16	proteins	protein	NNS
cord-354050-kcn67stj	63	17	may	may	MD
cord-354050-kcn67stj	63	18	sense	sense	VB
cord-354050-kcn67stj	63	19	membrane	membrane	NN
cord-354050-kcn67stj	63	20	changes	change	NNS
cord-354050-kcn67stj	63	21	occurring	occur	VBG
cord-354050-kcn67stj	63	22	during	during	IN
cord-354050-kcn67stj	63	23	virus	virus	NN
cord-354050-kcn67stj	63	24	-	-	HYPH
cord-354050-kcn67stj	63	25	driven	drive	VBN
cord-354050-kcn67stj	63	26	hemifusion	hemifusion	NN
cord-354050-kcn67stj	63	27	and	and	CC
cord-354050-kcn67stj	63	28	prevent	prevent	VB
cord-354050-kcn67stj	63	29	fusion	fusion	NN
cord-354050-kcn67stj	63	30	pore	pore	NN
cord-354050-kcn67stj	63	31	dilation	dilation	NN
cord-354050-kcn67stj	63	32	.	.	.
cord-354050-kcn67stj	64	1	These	these	DT
cord-354050-kcn67stj	64	2	latest	late	JJS
cord-354050-kcn67stj	64	3	findings	finding	NNS
cord-354050-kcn67stj	64	4	implicate	implicate	VBP
cord-354050-kcn67stj	64	5	the	the	DT
cord-354050-kcn67stj	64	6	first	first	JJ
cord-354050-kcn67stj	64	7	hydrophobic	hydrophobic	JJ
cord-354050-kcn67stj	64	8	domain	domain	NN
cord-354050-kcn67stj	64	9	(	(	-LRB-
cord-354050-kcn67stj	64	10	HD1	hd1	NN
cord-354050-kcn67stj	64	11	)	)	-RRB-
cord-354050-kcn67stj	64	12	of	of	IN
cord-354050-kcn67stj	64	13	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	64	14	as	as	IN
cord-354050-kcn67stj	64	15	the	the	DT
cord-354050-kcn67stj	64	16	functional	functional	JJ
cord-354050-kcn67stj	64	17	"	"	``
cord-354050-kcn67stj	64	18	arm	arm	NN
cord-354050-kcn67stj	64	19	"	"	''
cord-354050-kcn67stj	64	20	responsible	responsible	JJ
cord-354050-kcn67stj	64	21	for	for	IN
cord-354050-kcn67stj	64	22	its	-PRON-	PRP$
cord-354050-kcn67stj	64	23	antiviral	antiviral	JJ
cord-354050-kcn67stj	64	24	activity	activity	NN
cord-354050-kcn67stj	64	25	.	.	.
cord-354050-kcn67stj	65	1	However	however	RB
cord-354050-kcn67stj	65	2	,	,	,
cord-354050-kcn67stj	65	3	this	this	DT
cord-354050-kcn67stj	65	4	contrasts	contrast	VBZ
cord-354050-kcn67stj	65	5	with	with	IN
cord-354050-kcn67stj	65	6	a	a	DT
cord-354050-kcn67stj	65	7	previous	previous	JJ
cord-354050-kcn67stj	65	8	finding	finding	NN
cord-354050-kcn67stj	65	9	that	that	WDT
cord-354050-kcn67stj	65	10	proposed	propose	VBD
cord-354050-kcn67stj	65	11	a	a	DT
cord-354050-kcn67stj	65	12	role	role	NN
cord-354050-kcn67stj	65	13	for	for	IN
cord-354050-kcn67stj	65	14	HD2	HD2	NNP
cord-354050-kcn67stj	65	15	in	in	IN
cord-354050-kcn67stj	65	16	cholesterol	cholesterol	NN
cord-354050-kcn67stj	65	17	augmentation	augmentation	NN
cord-354050-kcn67stj	65	18	in	in	IN
cord-354050-kcn67stj	65	19	endosomes	endosome	NNS
cord-354050-kcn67stj	65	20	[	[	-LRB-
cord-354050-kcn67stj	65	21	28	28	CD
cord-354050-kcn67stj	65	22	]	]	-RRB-
cord-354050-kcn67stj	65	23	.	.	.
cord-354050-kcn67stj	66	1	Residues	residue	NNS
cord-354050-kcn67stj	66	2	within	within	IN
cord-354050-kcn67stj	66	3	HD2	HD2	NNP
cord-354050-kcn67stj	66	4	of	of	IN
cord-354050-kcn67stj	66	5	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	66	6	were	be	VBD
cord-354050-kcn67stj	66	7	reported	report	VBN
cord-354050-kcn67stj	66	8	to	to	TO
cord-354050-kcn67stj	66	9	interact	interact	VB
cord-354050-kcn67stj	66	10	with	with	IN
cord-354050-kcn67stj	66	11	the	the	DT
cord-354050-kcn67stj	66	12	vesicle	vesicle	NN
cord-354050-kcn67stj	66	13	-	-	HYPH
cord-354050-kcn67stj	66	14	associated	associate	VBN
cord-354050-kcn67stj	66	15	membrane	membrane	NN
cord-354050-kcn67stj	66	16	protein	protein	NN
cord-354050-kcn67stj	66	17	-	-	HYPH
cord-354050-kcn67stj	66	18	associated	associate	VBN
cord-354050-kcn67stj	66	19	A	a	NN
cord-354050-kcn67stj	66	20	(	(	-LRB-
cord-354050-kcn67stj	66	21	VAPA	VAPA	NNP
cord-354050-kcn67stj	66	22	)	)	-RRB-
cord-354050-kcn67stj	66	23	,	,	,
cord-354050-kcn67stj	66	24	previously	previously	RB
cord-354050-kcn67stj	66	25	linked	link	VBN
cord-354050-kcn67stj	66	26	to	to	IN
cord-354050-kcn67stj	66	27	cholesterol	cholesterol	NN
cord-354050-kcn67stj	66	28	trafficking	trafficking	NN
cord-354050-kcn67stj	66	29	.	.	.
cord-354050-kcn67stj	67	1	While	while	IN
cord-354050-kcn67stj	67	2	the	the	DT
cord-354050-kcn67stj	67	3	effects	effect	NNS
cord-354050-kcn67stj	67	4	of	of	IN
cord-354050-kcn67stj	67	5	cholesterol	cholesterol	NN
cord-354050-kcn67stj	67	6	on	on	IN
cord-354050-kcn67stj	67	7	membrane	membrane	NN
cord-354050-kcn67stj	67	8	fluidity	fluidity	NN
cord-354050-kcn67stj	67	9	and	and	CC
cord-354050-kcn67stj	67	10	virus	virus	NN
cord-354050-kcn67stj	67	11	-	-	HYPH
cord-354050-kcn67stj	67	12	cell	cell	NN
cord-354050-kcn67stj	67	13	fusion	fusion	NN
cord-354050-kcn67stj	67	14	are	be	VBP
cord-354050-kcn67stj	67	15	well	well	RB
cord-354050-kcn67stj	67	16	-	-	HYPH
cord-354050-kcn67stj	67	17	characterized	characterize	VBN
cord-354050-kcn67stj	67	18	,	,	,
cord-354050-kcn67stj	67	19	a	a	DT
cord-354050-kcn67stj	67	20	number	number	NN
cord-354050-kcn67stj	67	21	of	of	IN
cord-354050-kcn67stj	67	22	studies	study	NNS
cord-354050-kcn67stj	67	23	have	have	VBP
cord-354050-kcn67stj	67	24	failed	fail	VBN
cord-354050-kcn67stj	67	25	to	to	TO
cord-354050-kcn67stj	67	26	draw	draw	VB
cord-354050-kcn67stj	67	27	a	a	DT
cord-354050-kcn67stj	67	28	mechanistic	mechanistic	JJ
cord-354050-kcn67stj	67	29	link	link	NN
cord-354050-kcn67stj	67	30	between	between	IN
cord-354050-kcn67stj	67	31	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	67	32	activity	activity	NN
cord-354050-kcn67stj	67	33	and	and	CC
cord-354050-kcn67stj	67	34	cholesterol	cholesterol	NN
cord-354050-kcn67stj	67	35	levels	level	NNS
cord-354050-kcn67stj	67	36	[	[	-LRB-
cord-354050-kcn67stj	67	37	26	26	CD
cord-354050-kcn67stj	67	38	,	,	,
cord-354050-kcn67stj	67	39	27	27	CD
cord-354050-kcn67stj	67	40	,	,	,
cord-354050-kcn67stj	67	41	29	29	CD
cord-354050-kcn67stj	67	42	,	,	,
cord-354050-kcn67stj	67	43	30	30	CD
cord-354050-kcn67stj	67	44	]	]	-RRB-
cord-354050-kcn67stj	67	45	.	.	.
cord-354050-kcn67stj	68	1	Therefore	therefore	RB
cord-354050-kcn67stj	68	2	,	,	,
cord-354050-kcn67stj	68	3	effects	effect	NNS
cord-354050-kcn67stj	68	4	of	of	IN
cord-354050-kcn67stj	68	5	IFITM3	ifitm3	PRP
cord-354050-kcn67stj	68	6	on	on	IN
cord-354050-kcn67stj	68	7	lipid	lipid	NN
cord-354050-kcn67stj	68	8	trafficking	trafficking	NN
cord-354050-kcn67stj	68	9	may	may	MD
cord-354050-kcn67stj	68	10	not	not	RB
cord-354050-kcn67stj	68	11	underlie	underlie	VB
cord-354050-kcn67stj	68	12	virus	virus	NN
cord-354050-kcn67stj	68	13	inhibition	inhibition	NN
cord-354050-kcn67stj	68	14	,	,	,
cord-354050-kcn67stj	68	15	yet	yet	CC
cord-354050-kcn67stj	68	16	may	may	MD
cord-354050-kcn67stj	68	17	be	be	VB
cord-354050-kcn67stj	68	18	indicative	indicative	JJ
cord-354050-kcn67stj	68	19	of	of	IN
cord-354050-kcn67stj	68	20	presently	presently	RB
cord-354050-kcn67stj	68	21	uncharacterized	uncharacterized	JJ
cord-354050-kcn67stj	68	22	activities	activity	NNS
cord-354050-kcn67stj	68	23	in	in	IN
cord-354050-kcn67stj	68	24	the	the	DT
cord-354050-kcn67stj	68	25	cell	cell	NN
cord-354050-kcn67stj	68	26	.	.	.
cord-354050-kcn67stj	69	1	Interestingly	interestingly	RB
cord-354050-kcn67stj	69	2	,	,	,
cord-354050-kcn67stj	69	3	VAPA	VAPA	NNP
cord-354050-kcn67stj	69	4	and	and	CC
cord-354050-kcn67stj	69	5	the	the	DT
cord-354050-kcn67stj	69	6	related	related	JJ
cord-354050-kcn67stj	69	7	protein	protein	NN
cord-354050-kcn67stj	69	8	VAPB	VAPB	NNP
cord-354050-kcn67stj	69	9	can	can	MD
cord-354050-kcn67stj	69	10	enhance	enhance	VB
cord-354050-kcn67stj	69	11	the	the	DT
cord-354050-kcn67stj	69	12	replication	replication	NN
cord-354050-kcn67stj	69	13	of	of	IN
cord-354050-kcn67stj	69	14	some	some	DT
cord-354050-kcn67stj	69	15	viruses	virus	NNS
cord-354050-kcn67stj	69	16	,	,	,
cord-354050-kcn67stj	69	17	most	most	RBS
cord-354050-kcn67stj	69	18	likely	likely	JJ
cord-354050-kcn67stj	69	19	through	through	IN
cord-354050-kcn67stj	69	20	the	the	DT
cord-354050-kcn67stj	69	21	manipulation	manipulation	NN
cord-354050-kcn67stj	69	22	of	of	IN
cord-354050-kcn67stj	69	23	the	the	DT
cord-354050-kcn67stj	69	24	lipid	lipid	NN
cord-354050-kcn67stj	69	25	composition	composition	NN
cord-354050-kcn67stj	69	26	of	of	IN
cord-354050-kcn67stj	69	27	cell	cell	NN
cord-354050-kcn67stj	69	28	membranes	membrane	NNS
cord-354050-kcn67stj	69	29	used	use	VBN
cord-354050-kcn67stj	69	30	for	for	IN
cord-354050-kcn67stj	69	31	virus	virus	NN
cord-354050-kcn67stj	69	32	replication	replication	NN
cord-354050-kcn67stj	69	33	[	[	-LRB-
cord-354050-kcn67stj	69	34	31	31	CD
cord-354050-kcn67stj	69	35	,	,	,
cord-354050-kcn67stj	69	36	32	32	CD
cord-354050-kcn67stj	69	37	]	]	-RRB-
cord-354050-kcn67stj	69	38	.	.	.
cord-354050-kcn67stj	70	1	Overall	overall	RB
cord-354050-kcn67stj	70	2	,	,	,
cord-354050-kcn67stj	70	3	the	the	DT
cord-354050-kcn67stj	70	4	study	study	NN
cord-354050-kcn67stj	70	5	of	of	IN
cord-354050-kcn67stj	70	6	pathogenic	pathogenic	NNP
cord-354050-kcn67stj	70	7	RNA	RNA	NNP
cord-354050-kcn67stj	70	8	viruses	virus	NNS
cord-354050-kcn67stj	70	9	demonstrating	demonstrate	VBG
cord-354050-kcn67stj	70	10	a	a	DT
cord-354050-kcn67stj	70	11	high	high	JJ
cord-354050-kcn67stj	70	12	degree	degree	NN
cord-354050-kcn67stj	70	13	of	of	IN
cord-354050-kcn67stj	70	14	sensitivity	sensitivity	NN
cord-354050-kcn67stj	70	15	to	to	IN
cord-354050-kcn67stj	70	16	IFITM	IFITM	NNP
cord-354050-kcn67stj	70	17	-	-	HYPH
cord-354050-kcn67stj	70	18	mediated	mediate	VBN
cord-354050-kcn67stj	70	19	restriction	restriction	NN
cord-354050-kcn67stj	70	20	has	have	VBZ
cord-354050-kcn67stj	70	21	provided	provide	VBN
cord-354050-kcn67stj	70	22	some	some	DT
cord-354050-kcn67stj	70	23	mechanistic	mechanistic	JJ
cord-354050-kcn67stj	70	24	insight	insight	NN
cord-354050-kcn67stj	70	25	behind	behind	IN
cord-354050-kcn67stj	70	26	the	the	DT
cord-354050-kcn67stj	70	27	block	block	NN
cord-354050-kcn67stj	70	28	they	-PRON-	PRP
cord-354050-kcn67stj	70	29	impose	impose	VBP
cord-354050-kcn67stj	70	30	to	to	IN
cord-354050-kcn67stj	70	31	virus	virus	NN
cord-354050-kcn67stj	70	32	entry	entry	NN
cord-354050-kcn67stj	70	33	.	.	.
cord-354050-kcn67stj	71	1	Nevertheless	nevertheless	RB
cord-354050-kcn67stj	71	2	,	,	,
cord-354050-kcn67stj	71	3	the	the	DT
cord-354050-kcn67stj	71	4	demonstration	demonstration	NN
cord-354050-kcn67stj	71	5	that	that	IN
cord-354050-kcn67stj	71	6	certain	certain	JJ
cord-354050-kcn67stj	71	7	viruses	virus	NNS
cord-354050-kcn67stj	71	8	are	be	VBP
cord-354050-kcn67stj	71	9	resistant	resistant	JJ
cord-354050-kcn67stj	71	10	to	to	IN
cord-354050-kcn67stj	71	11	,	,	,
cord-354050-kcn67stj	71	12	or	or	CC
cord-354050-kcn67stj	71	13	even	even	RB
cord-354050-kcn67stj	71	14	benefit	benefit	VB
cord-354050-kcn67stj	71	15	from	from	IN
cord-354050-kcn67stj	71	16	,	,	,
cord-354050-kcn67stj	71	17	the	the	DT
cord-354050-kcn67stj	71	18	IFITM	IFITM	NNP
cord-354050-kcn67stj	71	19	proteins	protein	NNS
cord-354050-kcn67stj	71	20	indicates	indicate	VBZ
cord-354050-kcn67stj	71	21	that	that	IN
cord-354050-kcn67stj	71	22	antiviral	antiviral	JJ
cord-354050-kcn67stj	71	23	activity	activity	NN
cord-354050-kcn67stj	71	24	may	may	MD
cord-354050-kcn67stj	71	25	be	be	VB
cord-354050-kcn67stj	71	26	achieved	achieve	VBN
cord-354050-kcn67stj	71	27	through	through	IN
cord-354050-kcn67stj	71	28	the	the	DT
cord-354050-kcn67stj	71	29	coordination	coordination	NN
cord-354050-kcn67stj	71	30	of	of	IN
cord-354050-kcn67stj	71	31	other	other	JJ
cord-354050-kcn67stj	71	32	cellular	cellular	JJ
cord-354050-kcn67stj	71	33	proteins	protein	NNS
cord-354050-kcn67stj	71	34	.	.	.
cord-354050-kcn67stj	72	1	IFITM	ifitm	NN
cord-354050-kcn67stj	72	2	proteins	protein	NNS
cord-354050-kcn67stj	72	3	,	,	,
cord-354050-kcn67stj	72	4	especially	especially	RB
cord-354050-kcn67stj	72	5	IFITM1	ifitm1	NN
cord-354050-kcn67stj	72	6	,	,	,
cord-354050-kcn67stj	72	7	are	be	VBP
cord-354050-kcn67stj	72	8	known	know	VBN
cord-354050-kcn67stj	72	9	to	to	TO
cord-354050-kcn67stj	72	10	reside	reside	VB
cord-354050-kcn67stj	72	11	in	in	IN
cord-354050-kcn67stj	72	12	the	the	DT
cord-354050-kcn67stj	72	13	plasma	plasma	NN
cord-354050-kcn67stj	72	14	membrane	membrane	NN
cord-354050-kcn67stj	72	15	and	and	CC
cord-354050-kcn67stj	72	16	to	to	TO
cord-354050-kcn67stj	72	17	interact	interact	VB
cord-354050-kcn67stj	72	18	with	with	IN
cord-354050-kcn67stj	72	19	transmembrane	transmembrane	NN
cord-354050-kcn67stj	72	20	proteins	protein	NNS
cord-354050-kcn67stj	72	21	,	,	,
cord-354050-kcn67stj	72	22	such	such	JJ
cord-354050-kcn67stj	72	23	as	as	IN
cord-354050-kcn67stj	72	24	tetraspanins	tetraspanin	NNS
cord-354050-kcn67stj	72	25	.	.	.
cord-354050-kcn67stj	73	1	Hepatitis	Hepatitis	NNP
cord-354050-kcn67stj	73	2	C	C	NNP
cord-354050-kcn67stj	73	3	Virus	virus	NN
cord-354050-kcn67stj	73	4	(	(	-LRB-
cord-354050-kcn67stj	73	5	HCV	HCV	NNP
cord-354050-kcn67stj	73	6	)	)	-RRB-
cord-354050-kcn67stj	73	7	utilizes	utilize	VBZ
cord-354050-kcn67stj	73	8	CD81	CD81	NNP
cord-354050-kcn67stj	73	9	and	and	CC
cord-354050-kcn67stj	73	10	occludin	occludin	NNP
cord-354050-kcn67stj	73	11	as	as	IN
cord-354050-kcn67stj	73	12	co	co	NNS
cord-354050-kcn67stj	73	13	-	-	NNS
cord-354050-kcn67stj	73	14	receptors	receptor	NNS
cord-354050-kcn67stj	73	15	,	,	,
cord-354050-kcn67stj	73	16	which	which	WDT
cord-354050-kcn67stj	73	17	are	be	VBP
cord-354050-kcn67stj	73	18	components	component	NNS
cord-354050-kcn67stj	73	19	of	of	IN
cord-354050-kcn67stj	73	20	cellular	cellular	JJ
cord-354050-kcn67stj	73	21	tight	tight	JJ
cord-354050-kcn67stj	73	22	junctions	junction	NNS
cord-354050-kcn67stj	73	23	and	and	CC
cord-354050-kcn67stj	73	24	also	also	RB
cord-354050-kcn67stj	73	25	happen	happen	VB
cord-354050-kcn67stj	73	26	to	to	TO
cord-354050-kcn67stj	73	27	interact	interact	VB
cord-354050-kcn67stj	73	28	with	with	IN
cord-354050-kcn67stj	73	29	IFITM1	IFITM1	NNP
cord-354050-kcn67stj	73	30	[	[	-LRB-
cord-354050-kcn67stj	73	31	33	33	CD
cord-354050-kcn67stj	73	32	]	]	-RRB-
cord-354050-kcn67stj	73	33	.	.	.
cord-354050-kcn67stj	74	1	Overexpression	overexpression	NN
cord-354050-kcn67stj	74	2	of	of	IN
cord-354050-kcn67stj	74	3	IFITM1	IFITM1	NNP
cord-354050-kcn67stj	74	4	leads	lead	VBZ
cord-354050-kcn67stj	74	5	to	to	IN
cord-354050-kcn67stj	74	6	inhibition	inhibition	NN
cord-354050-kcn67stj	74	7	of	of	IN
cord-354050-kcn67stj	74	8	HCV	HCV	NNP
cord-354050-kcn67stj	74	9	entry	entry	NN
cord-354050-kcn67stj	74	10	into	into	IN
cord-354050-kcn67stj	74	11	cells	cell	NNS
cord-354050-kcn67stj	74	12	as	as	RB
cord-354050-kcn67stj	74	13	well	well	RB
cord-354050-kcn67stj	74	14	as	as	IN
cord-354050-kcn67stj	74	15	disruption	disruption	NN
cord-354050-kcn67stj	74	16	of	of	IN
cord-354050-kcn67stj	74	17	tight	tight	JJ
cord-354050-kcn67stj	74	18	junction	junction	NN
cord-354050-kcn67stj	74	19	complexes	complex	NNS
cord-354050-kcn67stj	74	20	,	,	,
cord-354050-kcn67stj	74	21	suggesting	suggest	VBG
cord-354050-kcn67stj	74	22	that	that	IN
cord-354050-kcn67stj	74	23	these	these	DT
cord-354050-kcn67stj	74	24	two	two	CD
cord-354050-kcn67stj	74	25	effects	effect	NNS
cord-354050-kcn67stj	74	26	are	be	VBP
cord-354050-kcn67stj	74	27	functionally	functionally	RB
cord-354050-kcn67stj	74	28	linked	link	VBN
cord-354050-kcn67stj	74	29	[	[	-LRB-
cord-354050-kcn67stj	74	30	34	34	CD
cord-354050-kcn67stj	74	31	]	]	-RRB-
cord-354050-kcn67stj	74	32	.	.	.
cord-354050-kcn67stj	75	1	Since	since	IN
cord-354050-kcn67stj	75	2	CD81	CD81	NNP
cord-354050-kcn67stj	75	3	and	and	CC
cord-354050-kcn67stj	75	4	other	other	JJ
cord-354050-kcn67stj	75	5	tetraspanin	tetraspanin	NNS
cord-354050-kcn67stj	75	6	proteins	protein	NNS
cord-354050-kcn67stj	75	7	can	can	MD
cord-354050-kcn67stj	75	8	modulate	modulate	VB
cord-354050-kcn67stj	75	9	fusion	fusion	NN
cord-354050-kcn67stj	75	10	events	event	NNS
cord-354050-kcn67stj	75	11	in	in	IN
cord-354050-kcn67stj	75	12	multiple	multiple	JJ
cord-354050-kcn67stj	75	13	virus	virus	NN
cord-354050-kcn67stj	75	14	infections	infection	NNS
cord-354050-kcn67stj	75	15	[	[	-LRB-
cord-354050-kcn67stj	75	16	35	35	CD
cord-354050-kcn67stj	75	17	]	]	-RRB-
cord-354050-kcn67stj	75	18	[	[	-LRB-
cord-354050-kcn67stj	75	19	36	36	CD
cord-354050-kcn67stj	75	20	]	]	-RRB-
cord-354050-kcn67stj	75	21	[	[	-LRB-
cord-354050-kcn67stj	75	22	37	37	CD
cord-354050-kcn67stj	75	23	]	]	-RRB-
cord-354050-kcn67stj	75	24	[	[	-LRB-
cord-354050-kcn67stj	75	25	38	38	CD
cord-354050-kcn67stj	75	26	]	]	-RRB-
cord-354050-kcn67stj	75	27	,	,	.
cord-354050-kcn67stj	76	1	the	the	DT
cord-354050-kcn67stj	76	2	ability	ability	NN
cord-354050-kcn67stj	76	3	for	for	IN
cord-354050-kcn67stj	76	4	IFITM	IFITM	NNP
cord-354050-kcn67stj	76	5	proteins	protein	NNS
cord-354050-kcn67stj	76	6	to	to	TO
cord-354050-kcn67stj	76	7	alter	alter	VB
cord-354050-kcn67stj	76	8	the	the	DT
cord-354050-kcn67stj	76	9	location	location	NN
cord-354050-kcn67stj	76	10	or	or	CC
cord-354050-kcn67stj	76	11	clustering	clustering	NN
cord-354050-kcn67stj	76	12	of	of	IN
cord-354050-kcn67stj	76	13	membrane	membrane	NN
cord-354050-kcn67stj	76	14	protein	protein	NN
cord-354050-kcn67stj	76	15	complexes	complex	NNS
cord-354050-kcn67stj	76	16	may	may	MD
cord-354050-kcn67stj	76	17	be	be	VB
cord-354050-kcn67stj	76	18	central	central	JJ
cord-354050-kcn67stj	76	19	to	to	IN
cord-354050-kcn67stj	76	20	their	-PRON-	PRP$
cord-354050-kcn67stj	76	21	antiviral	antiviral	JJ
cord-354050-kcn67stj	76	22	activity	activity	NN
cord-354050-kcn67stj	76	23	.	.	.
cord-354050-kcn67stj	77	1	An	an	DT
cord-354050-kcn67stj	77	2	'	'	``
cord-354050-kcn67stj	77	3	indirect	indirect	JJ
cord-354050-kcn67stj	77	4	'	'	''
cord-354050-kcn67stj	77	5	mode	mode	NN
cord-354050-kcn67stj	77	6	of	of	IN
cord-354050-kcn67stj	77	7	action	action	NN
cord-354050-kcn67stj	77	8	is	be	VBZ
cord-354050-kcn67stj	77	9	in	in	IN
cord-354050-kcn67stj	77	10	agreement	agreement	NN
cord-354050-kcn67stj	77	11	with	with	IN
cord-354050-kcn67stj	77	12	the	the	DT
cord-354050-kcn67stj	77	13	observation	observation	NN
cord-354050-kcn67stj	77	14	that	that	IN
cord-354050-kcn67stj	77	15	cellular	cellular	JJ
cord-354050-kcn67stj	77	16	entry	entry	NN
cord-354050-kcn67stj	77	17	of	of	IN
cord-354050-kcn67stj	77	18	the	the	DT
cord-354050-kcn67stj	77	19	coronavirus	coronavirus	NN
cord-354050-kcn67stj	77	20	HCoV	hcov	NN
cord-354050-kcn67stj	77	21	-	-	:
cord-354050-kcn67stj	77	22	OC43	OC43	NNP
cord-354050-kcn67stj	77	23	is	be	VBZ
cord-354050-kcn67stj	77	24	promoted	promote	VBN
cord-354050-kcn67stj	77	25	by	by	IN
cord-354050-kcn67stj	77	26	IFITM	IFITM	NNP
cord-354050-kcn67stj	77	27	proteins	protein	NNS
cord-354050-kcn67stj	77	28	[	[	-LRB-
cord-354050-kcn67stj	77	29	39	39	CD
cord-354050-kcn67stj	77	30	]	]	-RRB-
cord-354050-kcn67stj	77	31	.	.	.
cord-354050-kcn67stj	78	1	This	this	DT
cord-354050-kcn67stj	78	2	exceptional	exceptional	JJ
cord-354050-kcn67stj	78	3	case	case	NN
cord-354050-kcn67stj	78	4	may	may	MD
cord-354050-kcn67stj	78	5	be	be	VB
cord-354050-kcn67stj	78	6	explained	explain	VBN
cord-354050-kcn67stj	78	7	by	by	IN
cord-354050-kcn67stj	78	8	the	the	DT
cord-354050-kcn67stj	78	9	fact	fact	NN
cord-354050-kcn67stj	78	10	that	that	IN
cord-354050-kcn67stj	78	11	different	different	JJ
cord-354050-kcn67stj	78	12	viruses	virus	NNS
cord-354050-kcn67stj	78	13	take	take	VBP
cord-354050-kcn67stj	78	14	advantage	advantage	NN
cord-354050-kcn67stj	78	15	of	of	IN
cord-354050-kcn67stj	78	16	distinct	distinct	JJ
cord-354050-kcn67stj	78	17	cellular	cellular	JJ
cord-354050-kcn67stj	78	18	receptors	receptor	NNS
cord-354050-kcn67stj	78	19	and	and	CC
cord-354050-kcn67stj	78	20	thus	thus	RB
cord-354050-kcn67stj	78	21	distinct	distinct	JJ
cord-354050-kcn67stj	78	22	entry	entry	NN
cord-354050-kcn67stj	78	23	routes	route	NNS
cord-354050-kcn67stj	78	24	that	that	WDT
cord-354050-kcn67stj	78	25	are	be	VBP
cord-354050-kcn67stj	78	26	differentially	differentially	RB
cord-354050-kcn67stj	78	27	impacted	impact	VBN
cord-354050-kcn67stj	78	28	by	by	IN
cord-354050-kcn67stj	78	29	the	the	DT
cord-354050-kcn67stj	78	30	presence	presence	NN
cord-354050-kcn67stj	78	31	of	of	IN
cord-354050-kcn67stj	78	32	IFITM	IFITM	NNP
cord-354050-kcn67stj	78	33	proteins	protein	NNS
cord-354050-kcn67stj	78	34	.	.	.
cord-354050-kcn67stj	79	1	A	a	DT
cord-354050-kcn67stj	79	2	transmembrane	transmembrane	NN
cord-354050-kcn67stj	79	3	metalloprotease	metalloprotease	NN
cord-354050-kcn67stj	79	4	known	know	VBN
cord-354050-kcn67stj	79	5	as	as	IN
cord-354050-kcn67stj	79	6	ZMP	ZMP	NNP
cord-354050-kcn67stj	79	7	-	-	HYPH
cord-354050-kcn67stj	79	8	STE24	STE24	NNP
cord-354050-kcn67stj	79	9	(	(	-LRB-
cord-354050-kcn67stj	79	10	also	also	RB
cord-354050-kcn67stj	79	11	known	know	VBN
cord-354050-kcn67stj	79	12	as	as	IN
cord-354050-kcn67stj	79	13	FACE1	face1	NN
cord-354050-kcn67stj	79	14	)	)	-RRB-
cord-354050-kcn67stj	79	15	has	have	VBZ
cord-354050-kcn67stj	79	16	recently	recently	RB
cord-354050-kcn67stj	79	17	emerged	emerge	VBN
cord-354050-kcn67stj	79	18	as	as	IN
cord-354050-kcn67stj	79	19	a	a	DT
cord-354050-kcn67stj	79	20	downstream	downstream	JJ
cord-354050-kcn67stj	79	21	effector	effector	NN
cord-354050-kcn67stj	79	22	of	of	IN
cord-354050-kcn67stj	79	23	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	79	24	[	[	-LRB-
cord-354050-kcn67stj	79	25	40	40	CD
cord-354050-kcn67stj	79	26	]	]	-RRB-
cord-354050-kcn67stj	79	27	.	.	.
cord-354050-kcn67stj	80	1	The	the	DT
cord-354050-kcn67stj	80	2	authors	author	NNS
cord-354050-kcn67stj	80	3	posit	posit	VBP
cord-354050-kcn67stj	80	4	that	that	IN
cord-354050-kcn67stj	80	5	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	80	6	traffics	traffic	VBZ
cord-354050-kcn67stj	80	7	ZMPSTE24	ZMPSTE24	NNP
cord-354050-kcn67stj	80	8	to	to	IN
cord-354050-kcn67stj	80	9	the	the	DT
cord-354050-kcn67stj	80	10	sites	site	NNS
cord-354050-kcn67stj	80	11	of	of	IN
cord-354050-kcn67stj	80	12	virus	virus	NN
cord-354050-kcn67stj	80	13	fusion	fusion	NN
cord-354050-kcn67stj	80	14	at	at	IN
cord-354050-kcn67stj	80	15	endosomes	endosome	NNS
cord-354050-kcn67stj	80	16	via	via	IN
cord-354050-kcn67stj	80	17	a	a	DT
cord-354050-kcn67stj	80	18	direct	direct	JJ
cord-354050-kcn67stj	80	19	protein	protein	NN
cord-354050-kcn67stj	80	20	-	-	HYPH
cord-354050-kcn67stj	80	21	protein	protein	NN
cord-354050-kcn67stj	80	22	interaction	interaction	NN
cord-354050-kcn67stj	80	23	.	.	.
cord-354050-kcn67stj	81	1	Importantly	importantly	RB
cord-354050-kcn67stj	81	2	,	,	,
cord-354050-kcn67stj	81	3	in	in	IN
cord-354050-kcn67stj	81	4	ZMPSTE24	zmpste24	NN
cord-354050-kcn67stj	81	5	knockout	knockout	NN
cord-354050-kcn67stj	81	6	cells	cell	NNS
cord-354050-kcn67stj	81	7	,	,	,
cord-354050-kcn67stj	81	8	IFITM3	IFITM3	''
cord-354050-kcn67stj	82	1	overexpression	overexpression	NN
cord-354050-kcn67stj	82	2	no	no	RB
cord-354050-kcn67stj	82	3	longer	long	RBR
cord-354050-kcn67stj	82	4	provides	provide	VBZ
cord-354050-kcn67stj	82	5	protection	protection	NN
cord-354050-kcn67stj	82	6	from	from	IN
cord-354050-kcn67stj	82	7	virus	virus	NN
cord-354050-kcn67stj	82	8	challenge	challenge	NN
cord-354050-kcn67stj	82	9	.	.	.
cord-354050-kcn67stj	83	1	No	no	DT
cord-354050-kcn67stj	83	2	mechanistic	mechanistic	JJ
cord-354050-kcn67stj	83	3	information	information	NN
cord-354050-kcn67stj	83	4	is	be	VBZ
cord-354050-kcn67stj	83	5	available	available	JJ
cord-354050-kcn67stj	83	6	for	for	IN
cord-354050-kcn67stj	83	7	the	the	DT
cord-354050-kcn67stj	83	8	antiviral	antiviral	JJ
cord-354050-kcn67stj	83	9	activities	activity	NNS
cord-354050-kcn67stj	83	10	of	of	IN
cord-354050-kcn67stj	83	11	ZMPSTE24	ZMPSTE24	NNP
cord-354050-kcn67stj	83	12	and	and	CC
cord-354050-kcn67stj	83	13	thus	thus	RB
cord-354050-kcn67stj	83	14	future	future	JJ
cord-354050-kcn67stj	83	15	studies	study	NNS
cord-354050-kcn67stj	83	16	must	must	MD
cord-354050-kcn67stj	83	17	address	address	VB
cord-354050-kcn67stj	83	18	the	the	DT
cord-354050-kcn67stj	83	19	specific	specific	JJ
cord-354050-kcn67stj	83	20	determinants	determinant	NNS
cord-354050-kcn67stj	83	21	of	of	IN
cord-354050-kcn67stj	83	22	how	how	WRB
cord-354050-kcn67stj	83	23	it	-PRON-	PRP
cord-354050-kcn67stj	83	24	binds	bind	VBZ
cord-354050-kcn67stj	83	25	to	to	IN
cord-354050-kcn67stj	83	26	IFITM3	ifitm3	PRP
cord-354050-kcn67stj	83	27	.	.	.
cord-354050-kcn67stj	84	1	It	-PRON-	PRP
cord-354050-kcn67stj	84	2	is	be	VBZ
cord-354050-kcn67stj	84	3	possible	possible	JJ
cord-354050-kcn67stj	84	4	that	that	IN
cord-354050-kcn67stj	84	5	domains	domain	NNS
cord-354050-kcn67stj	84	6	of	of	IN
cord-354050-kcn67stj	84	7	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	84	8	previously	previously	RB
cord-354050-kcn67stj	84	9	shown	show	VBN
cord-354050-kcn67stj	84	10	to	to	TO
cord-354050-kcn67stj	84	11	be	be	VB
cord-354050-kcn67stj	84	12	essential	essential	JJ
cord-354050-kcn67stj	84	13	for	for	IN
cord-354050-kcn67stj	84	14	antiviral	antiviral	JJ
cord-354050-kcn67stj	84	15	function	function	NN
cord-354050-kcn67stj	84	16	play	play	VBP
cord-354050-kcn67stj	84	17	roles	role	NNS
cord-354050-kcn67stj	84	18	in	in	IN
cord-354050-kcn67stj	84	19	modulating	modulate	VBG
cord-354050-kcn67stj	84	20	the	the	DT
cord-354050-kcn67stj	84	21	location	location	NN
cord-354050-kcn67stj	84	22	or	or	CC
cord-354050-kcn67stj	84	23	function	function	NN
cord-354050-kcn67stj	84	24	of	of	IN
cord-354050-kcn67stj	84	25	this	this	DT
cord-354050-kcn67stj	84	26	and	and	CC
cord-354050-kcn67stj	84	27	other	other	JJ
cord-354050-kcn67stj	84	28	cellular	cellular	JJ
cord-354050-kcn67stj	84	29	factors	factor	NNS
cord-354050-kcn67stj	84	30	,	,	,
cord-354050-kcn67stj	84	31	resulting	result	VBG
cord-354050-kcn67stj	84	32	in	in	IN
cord-354050-kcn67stj	84	33	an	an	DT
cord-354050-kcn67stj	84	34	organized	organized	JJ
cord-354050-kcn67stj	84	35	block	block	NN
cord-354050-kcn67stj	84	36	to	to	IN
cord-354050-kcn67stj	84	37	virus	virus	NN
cord-354050-kcn67stj	84	38	entry	entry	NN
cord-354050-kcn67stj	84	39	.	.	.
cord-354050-kcn67stj	85	1	The	the	DT
cord-354050-kcn67stj	85	2	path	path	NN
cord-354050-kcn67stj	85	3	to	to	IN
cord-354050-kcn67stj	85	4	identifying	identify	VBG
cord-354050-kcn67stj	85	5	the	the	DT
cord-354050-kcn67stj	85	6	roles	role	NNS
cord-354050-kcn67stj	85	7	played	play	VBN
cord-354050-kcn67stj	85	8	by	by	IN
cord-354050-kcn67stj	85	9	IFITM	IFITM	NNP
cord-354050-kcn67stj	85	10	proteins	protein	NNS
cord-354050-kcn67stj	85	11	during	during	IN
cord-354050-kcn67stj	85	12	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	85	13	infection	infection	NN
cord-354050-kcn67stj	85	14	was	be	VBD
cord-354050-kcn67stj	85	15	less	less	RBR
cord-354050-kcn67stj	85	16	straightforward	straightforward	JJ
cord-354050-kcn67stj	85	17	for	for	IN
cord-354050-kcn67stj	85	18	multiple	multiple	JJ
cord-354050-kcn67stj	85	19	reasons	reason	NNS
cord-354050-kcn67stj	85	20	.	.	.
cord-354050-kcn67stj	86	1	First	first	RB
cord-354050-kcn67stj	86	2	,	,	,
cord-354050-kcn67stj	86	3	while	while	IN
cord-354050-kcn67stj	86	4	the	the	DT
cord-354050-kcn67stj	86	5	impact	impact	NN
cord-354050-kcn67stj	86	6	of	of	IN
cord-354050-kcn67stj	86	7	IFITM	IFITM	NNP
cord-354050-kcn67stj	86	8	proteins	protein	NNS
cord-354050-kcn67stj	86	9	on	on	IN
cord-354050-kcn67stj	86	10	viruses	virus	NNS
cord-354050-kcn67stj	86	11	that	that	WDT
cord-354050-kcn67stj	86	12	require	require	VBP
cord-354050-kcn67stj	86	13	endocytosis	endocytosis	NN
cord-354050-kcn67stj	86	14	and	and	CC
cord-354050-kcn67stj	86	15	pH	ph	NN
cord-354050-kcn67stj	86	16	-	-	HYPH
cord-354050-kcn67stj	86	17	dependent	dependent	JJ
cord-354050-kcn67stj	86	18	fusion	fusion	NN
cord-354050-kcn67stj	86	19	is	be	VBZ
cord-354050-kcn67stj	86	20	clearly	clearly	RB
cord-354050-kcn67stj	86	21	appreciated	appreciate	VBN
cord-354050-kcn67stj	86	22	,	,	,
cord-354050-kcn67stj	86	23	the	the	DT
cord-354050-kcn67stj	86	24	role	role	NN
cord-354050-kcn67stj	86	25	for	for	IN
cord-354050-kcn67stj	86	26	endocytosis	endocytosis	NN
cord-354050-kcn67stj	86	27	in	in	IN
cord-354050-kcn67stj	86	28	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	86	29	cellular	cellular	JJ
cord-354050-kcn67stj	86	30	entry	entry	NN
cord-354050-kcn67stj	86	31	has	have	VBZ
cord-354050-kcn67stj	86	32	been	be	VBN
cord-354050-kcn67stj	86	33	widely	widely	RB
cord-354050-kcn67stj	86	34	debated	debate	VBN
cord-354050-kcn67stj	86	35	[	[	-LRB-
cord-354050-kcn67stj	86	36	41	41	CD
cord-354050-kcn67stj	86	37	]	]	-RRB-
cord-354050-kcn67stj	86	38	.	.	.
cord-354050-kcn67stj	87	1	Second	second	RB
cord-354050-kcn67stj	87	2	,	,	,
cord-354050-kcn67stj	87	3	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	87	4	exhibits	exhibit	VBZ
cord-354050-kcn67stj	87	5	the	the	DT
cord-354050-kcn67stj	87	6	capacity	capacity	NN
cord-354050-kcn67stj	87	7	to	to	TO
cord-354050-kcn67stj	87	8	spread	spread	VB
cord-354050-kcn67stj	87	9	between	between	IN
cord-354050-kcn67stj	87	10	cells	cell	NNS
cord-354050-kcn67stj	87	11	in	in	IN
cord-354050-kcn67stj	87	12	a	a	DT
cord-354050-kcn67stj	87	13	process	process	NN
cord-354050-kcn67stj	87	14	known	know	VBN
cord-354050-kcn67stj	87	15	as	as	IN
cord-354050-kcn67stj	87	16	cell	cell	NN
cord-354050-kcn67stj	87	17	-	-	HYPH
cord-354050-kcn67stj	87	18	to	to	IN
cord-354050-kcn67stj	87	19	-	-	HYPH
cord-354050-kcn67stj	87	20	cell	cell	NN
cord-354050-kcn67stj	87	21	transmission	transmission	NN
cord-354050-kcn67stj	87	22	,	,	,
cord-354050-kcn67stj	87	23	which	which	WDT
cord-354050-kcn67stj	87	24	likely	likely	RB
cord-354050-kcn67stj	87	25	allows	allow	VBZ
cord-354050-kcn67stj	87	26	escape	escape	NN
cord-354050-kcn67stj	87	27	from	from	IN
cord-354050-kcn67stj	87	28	immune	immune	JJ
cord-354050-kcn67stj	87	29	barriers	barrier	NNS
cord-354050-kcn67stj	87	30	[	[	-LRB-
cord-354050-kcn67stj	87	31	42	42	CD
cord-354050-kcn67stj	87	32	]	]	-RRB-
cord-354050-kcn67stj	87	33	.	.	.
cord-354050-kcn67stj	88	1	Despite	despite	IN
cord-354050-kcn67stj	88	2	these	these	DT
cord-354050-kcn67stj	88	3	challenges	challenge	NNS
cord-354050-kcn67stj	88	4	,	,	,
cord-354050-kcn67stj	88	5	the	the	DT
cord-354050-kcn67stj	88	6	study	study	NN
cord-354050-kcn67stj	88	7	of	of	IN
cord-354050-kcn67stj	88	8	IFITM	IFITM	NNP
cord-354050-kcn67stj	88	9	and	and	CC
cord-354050-kcn67stj	88	10	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	88	11	was	be	VBD
cord-354050-kcn67stj	88	12	mutually	mutually	RB
cord-354050-kcn67stj	88	13	instructive	instructive	JJ
cord-354050-kcn67stj	88	14	:	:	:
cord-354050-kcn67stj	88	15	a	a	DT
cord-354050-kcn67stj	88	16	new	new	JJ
cord-354050-kcn67stj	88	17	antiviral	antiviral	JJ
cord-354050-kcn67stj	88	18	function	function	NN
cord-354050-kcn67stj	88	19	was	be	VBD
cord-354050-kcn67stj	88	20	described	describe	VBN
cord-354050-kcn67stj	88	21	for	for	IN
cord-354050-kcn67stj	88	22	the	the	DT
cord-354050-kcn67stj	88	23	former	former	JJ
cord-354050-kcn67stj	88	24	and	and	CC
cord-354050-kcn67stj	88	25	the	the	DT
cord-354050-kcn67stj	88	26	ports	port	NNS
cord-354050-kcn67stj	88	27	of	of	IN
cord-354050-kcn67stj	88	28	cellular	cellular	JJ
cord-354050-kcn67stj	88	29	entry	entry	NN
cord-354050-kcn67stj	88	30	were	be	VBD
cord-354050-kcn67stj	88	31	defined	define	VBN
cord-354050-kcn67stj	88	32	for	for	IN
cord-354050-kcn67stj	88	33	the	the	DT
cord-354050-kcn67stj	88	34	latter	latter	JJ
cord-354050-kcn67stj	88	35	.	.	.
cord-354050-kcn67stj	89	1	In	in	IN
cord-354050-kcn67stj	89	2	the	the	DT
cord-354050-kcn67stj	89	3	first	first	JJ
cord-354050-kcn67stj	89	4	formal	formal	JJ
cord-354050-kcn67stj	89	5	description	description	NN
cord-354050-kcn67stj	89	6	of	of	IN
cord-354050-kcn67stj	89	7	the	the	DT
cord-354050-kcn67stj	89	8	antiviral	antiviral	JJ
cord-354050-kcn67stj	89	9	properties	property	NNS
cord-354050-kcn67stj	89	10	of	of	IN
cord-354050-kcn67stj	89	11	IFITM	IFITM	NNP
cord-354050-kcn67stj	89	12	family	family	NN
cord-354050-kcn67stj	89	13	members	member	NNS
cord-354050-kcn67stj	89	14	,	,	,
cord-354050-kcn67stj	89	15	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	89	16	silencing	silence	VBG
cord-354050-kcn67stj	89	17	had	have	VBD
cord-354050-kcn67stj	89	18	little	little	JJ
cord-354050-kcn67stj	89	19	to	to	IN
cord-354050-kcn67stj	89	20	no	no	DT
cord-354050-kcn67stj	89	21	effect	effect	NN
cord-354050-kcn67stj	89	22	on	on	IN
cord-354050-kcn67stj	89	23	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	89	24	infection	infection	NN
cord-354050-kcn67stj	89	25	in	in	IN
cord-354050-kcn67stj	89	26	HeLa	HeLa	NNP
cord-354050-kcn67stj	89	27	-	-	HYPH
cord-354050-kcn67stj	89	28	CD4	CD4	NNP
cord-354050-kcn67stj	89	29	cells	cell	NNS
cord-354050-kcn67stj	89	30	,	,	,
cord-354050-kcn67stj	89	31	thus	thus	RB
cord-354050-kcn67stj	89	32	grouping	group	VBG
cord-354050-kcn67stj	89	33	it	-PRON-	PRP
cord-354050-kcn67stj	89	34	with	with	IN
cord-354050-kcn67stj	89	35	another	another	DT
cord-354050-kcn67stj	89	36	retrovirus	retrovirus	NN
cord-354050-kcn67stj	89	37	(	(	-LRB-
cord-354050-kcn67stj	89	38	amphotropic	amphotropic	NNP
cord-354050-kcn67stj	89	39	Murine	Murine	NNP
cord-354050-kcn67stj	89	40	Leukemia	Leukemia	NNP
cord-354050-kcn67stj	89	41	Virus	Virus	NNP
cord-354050-kcn67stj	89	42	)	)	-RRB-
cord-354050-kcn67stj	89	43	deemed	deem	VBD
cord-354050-kcn67stj	89	44	to	to	TO
cord-354050-kcn67stj	89	45	be	be	VB
cord-354050-kcn67stj	89	46	resistant	resistant	JJ
cord-354050-kcn67stj	89	47	[	[	-LRB-
cord-354050-kcn67stj	89	48	8	8	CD
cord-354050-kcn67stj	89	49	]	]	-RRB-
cord-354050-kcn67stj	89	50	.	.	.
cord-354050-kcn67stj	90	1	Also	also	RB
cord-354050-kcn67stj	90	2	,	,	,
cord-354050-kcn67stj	90	3	in	in	IN
cord-354050-kcn67stj	90	4	the	the	DT
cord-354050-kcn67stj	90	5	paper	paper	NN
cord-354050-kcn67stj	90	6	that	that	WDT
cord-354050-kcn67stj	90	7	identified	identify	VBD
cord-354050-kcn67stj	90	8	tetherin	tetherin	NNP
cord-354050-kcn67stj	90	9	/	/	SYM
cord-354050-kcn67stj	90	10	BST-2	BST-2	NNP
cord-354050-kcn67stj	90	11	as	as	IN
cord-354050-kcn67stj	90	12	the	the	DT
cord-354050-kcn67stj	90	13	target	target	NN
cord-354050-kcn67stj	90	14	of	of	IN
cord-354050-kcn67stj	90	15	viral	viral	JJ
cord-354050-kcn67stj	90	16	accessory	accessory	NN
cord-354050-kcn67stj	90	17	protein	protein	NN
cord-354050-kcn67stj	90	18	Vpu	Vpu	NNP
cord-354050-kcn67stj	90	19	,	,	,
cord-354050-kcn67stj	90	20	which	which	WDT
cord-354050-kcn67stj	90	21	promotes	promote	VBZ
cord-354050-kcn67stj	90	22	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	90	23	release	release	NN
cord-354050-kcn67stj	90	24	from	from	IN
cord-354050-kcn67stj	90	25	cells	cell	NNS
cord-354050-kcn67stj	90	26	,	,	,
cord-354050-kcn67stj	90	27	it	-PRON-	PRP
cord-354050-kcn67stj	90	28	was	be	VBD
cord-354050-kcn67stj	90	29	shown	show	VBN
cord-354050-kcn67stj	90	30	that	that	IN
cord-354050-kcn67stj	90	31	IFITM	IFITM	NNP
cord-354050-kcn67stj	90	32	proteins	protein	NNS
cord-354050-kcn67stj	90	33	exhibited	exhibit	VBD
cord-354050-kcn67stj	90	34	no	no	DT
cord-354050-kcn67stj	90	35	impact	impact	NN
cord-354050-kcn67stj	90	36	on	on	IN
cord-354050-kcn67stj	90	37	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	90	38	egress	egress	NN
cord-354050-kcn67stj	90	39	[	[	-LRB-
cord-354050-kcn67stj	90	40	43	43	CD
cord-354050-kcn67stj	90	41	]	]	-RRB-
cord-354050-kcn67stj	90	42	.	.	.
cord-354050-kcn67stj	91	1	However	however	RB
cord-354050-kcn67stj	91	2	,	,	,
cord-354050-kcn67stj	91	3	two	two	CD
cord-354050-kcn67stj	91	4	highthroughput	highthroughput	NN
cord-354050-kcn67stj	91	5	screens	screen	NNS
cord-354050-kcn67stj	91	6	studying	study	VBG
cord-354050-kcn67stj	91	7	the	the	DT
cord-354050-kcn67stj	91	8	activities	activity	NNS
cord-354050-kcn67stj	91	9	of	of	IN
cord-354050-kcn67stj	91	10	interferon	interferon	NN
cord-354050-kcn67stj	91	11	stimulated	stimulate	VBD
cord-354050-kcn67stj	91	12	genes	gene	NNS
cord-354050-kcn67stj	91	13	(	(	-LRB-
cord-354050-kcn67stj	91	14	ISGs	ISGs	NNP
cord-354050-kcn67stj	91	15	)	)	-RRB-
cord-354050-kcn67stj	91	16	provided	provide	VBD
cord-354050-kcn67stj	91	17	evidence	evidence	NN
cord-354050-kcn67stj	91	18	that	that	IN
cord-354050-kcn67stj	91	19	IFITM	IFITM	NNP
cord-354050-kcn67stj	91	20	proteins	protein	NNS
cord-354050-kcn67stj	91	21	impact	impact	VBP
cord-354050-kcn67stj	91	22	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	91	23	replication	replication	NN
cord-354050-kcn67stj	91	24	when	when	WRB
cord-354050-kcn67stj	91	25	silenced	silence	VBN
cord-354050-kcn67stj	91	26	or	or	CC
cord-354050-kcn67stj	91	27	overexpressed	overexpresse	VBN
cord-354050-kcn67stj	91	28	[	[	-LRB-
cord-354050-kcn67stj	91	29	44	44	CD
cord-354050-kcn67stj	91	30	,	,	,
cord-354050-kcn67stj	91	31	45	45	CD
cord-354050-kcn67stj	91	32	]	]	-RRB-
cord-354050-kcn67stj	91	33	.	.	.
cord-354050-kcn67stj	92	1	Lu	Lu	NNP
cord-354050-kcn67stj	92	2	et	et	FW
cord-354050-kcn67stj	92	3	al	al	NNP
cord-354050-kcn67stj	92	4	.	.	.
cord-354050-kcn67stj	93	1	provided	provide	VBD
cord-354050-kcn67stj	93	2	the	the	DT
cord-354050-kcn67stj	93	3	first	first	JJ
cord-354050-kcn67stj	93	4	in	in	IN
cord-354050-kcn67stj	93	5	-	-	HYPH
cord-354050-kcn67stj	93	6	depth	depth	NN
cord-354050-kcn67stj	93	7	functional	functional	JJ
cord-354050-kcn67stj	93	8	demonstration	demonstration	NN
cord-354050-kcn67stj	93	9	of	of	IN
cord-354050-kcn67stj	93	10	IFITM	IFITM	NNP
cord-354050-kcn67stj	93	11	-	-	HYPH
cord-354050-kcn67stj	93	12	mediated	mediate	VBN
cord-354050-kcn67stj	93	13	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	93	14	restriction	restriction	NN
cord-354050-kcn67stj	93	15	at	at	IN
cord-354050-kcn67stj	93	16	the	the	DT
cord-354050-kcn67stj	93	17	level	level	NN
cord-354050-kcn67stj	93	18	of	of	IN
cord-354050-kcn67stj	93	19	entry	entry	NN
cord-354050-kcn67stj	93	20	in	in	IN
cord-354050-kcn67stj	93	21	T	t	NN
cord-354050-kcn67stj	93	22	cells	cell	NNS
cord-354050-kcn67stj	93	23	,	,	,
cord-354050-kcn67stj	93	24	and	and	CC
cord-354050-kcn67stj	93	25	this	this	DT
cord-354050-kcn67stj	93	26	work	work	NN
cord-354050-kcn67stj	93	27	was	be	VBD
cord-354050-kcn67stj	93	28	later	later	RB
cord-354050-kcn67stj	93	29	extended	extend	VBN
cord-354050-kcn67stj	93	30	to	to	IN
cord-354050-kcn67stj	93	31	other	other	JJ
cord-354050-kcn67stj	93	32	lentiviruses	lentiviruse	NNS
cord-354050-kcn67stj	93	33	of	of	IN
cord-354050-kcn67stj	93	34	non	non	JJ
cord-354050-kcn67stj	93	35	-	-	JJ
cord-354050-kcn67stj	93	36	human	human	JJ
cord-354050-kcn67stj	93	37	primates	primate	NNS
cord-354050-kcn67stj	93	38	[	[	-LRB-
cord-354050-kcn67stj	93	39	46	46	CD
cord-354050-kcn67stj	93	40	]	]	-RRB-
cord-354050-kcn67stj	93	41	.	.	.
cord-354050-kcn67stj	94	1	In	in	IN
cord-354050-kcn67stj	94	2	addition	addition	NN
cord-354050-kcn67stj	94	3	,	,	,
cord-354050-kcn67stj	94	4	experiments	experiment	NNS
cord-354050-kcn67stj	94	5	allowing	allow	VBG
cord-354050-kcn67stj	94	6	ongoing	ongoing	JJ
cord-354050-kcn67stj	94	7	replication	replication	NN
cord-354050-kcn67stj	94	8	in	in	IN
cord-354050-kcn67stj	94	9	tissue	tissue	NN
cord-354050-kcn67stj	94	10	culture	culture	NN
cord-354050-kcn67stj	94	11	revealed	reveal	VBD
cord-354050-kcn67stj	94	12	that	that	IN
cord-354050-kcn67stj	94	13	the	the	DT
cord-354050-kcn67stj	94	14	antiviral	antiviral	JJ
cord-354050-kcn67stj	94	15	properties	property	NNS
cord-354050-kcn67stj	94	16	of	of	IN
cord-354050-kcn67stj	94	17	IFITM	IFITM	NNP
cord-354050-kcn67stj	94	18	proteins	protein	NNS
cord-354050-kcn67stj	94	19	may	may	MD
cord-354050-kcn67stj	94	20	not	not	RB
cord-354050-kcn67stj	94	21	be	be	VB
cord-354050-kcn67stj	94	22	limited	limit	VBN
cord-354050-kcn67stj	94	23	to	to	IN
cord-354050-kcn67stj	94	24	the	the	DT
cord-354050-kcn67stj	94	25	inhibition	inhibition	NN
cord-354050-kcn67stj	94	26	of	of	IN
cord-354050-kcn67stj	94	27	virus	virus	NN
cord-354050-kcn67stj	94	28	entry	entry	NN
cord-354050-kcn67stj	94	29	(	(	-LRB-
cord-354050-kcn67stj	94	30	see	see	VB
cord-354050-kcn67stj	94	31	next	next	JJ
cord-354050-kcn67stj	94	32	section	section	NN
cord-354050-kcn67stj	94	33	)	)	-RRB-
cord-354050-kcn67stj	94	34	.	.	.
cord-354050-kcn67stj	95	1	As	as	IN
cord-354050-kcn67stj	95	2	the	the	DT
cord-354050-kcn67stj	95	3	primary	primary	JJ
cord-354050-kcn67stj	95	4	determinant	determinant	NN
cord-354050-kcn67stj	95	5	for	for	IN
cord-354050-kcn67stj	95	6	virus	virus	NN
cord-354050-kcn67stj	95	7	-	-	HYPH
cord-354050-kcn67stj	95	8	cell	cell	NN
cord-354050-kcn67stj	95	9	attachment	attachment	NN
cord-354050-kcn67stj	95	10	and	and	CC
cord-354050-kcn67stj	95	11	the	the	DT
cord-354050-kcn67stj	95	12	subsequent	subsequent	JJ
cord-354050-kcn67stj	95	13	fusion	fusion	NN
cord-354050-kcn67stj	95	14	reaction	reaction	NN
cord-354050-kcn67stj	95	15	,	,	,
cord-354050-kcn67stj	95	16	the	the	DT
cord-354050-kcn67stj	95	17	viral	viral	JJ
cord-354050-kcn67stj	95	18	envelope	envelope	NN
cord-354050-kcn67stj	95	19	glycoprotein	glycoprotein	NN
cord-354050-kcn67stj	95	20	(	(	-LRB-
cord-354050-kcn67stj	95	21	Env	Env	NNP
cord-354050-kcn67stj	95	22	)	)	-RRB-
cord-354050-kcn67stj	95	23	was	be	VBD
cord-354050-kcn67stj	95	24	suspected	suspect	VBN
cord-354050-kcn67stj	95	25	to	to	TO
cord-354050-kcn67stj	95	26	play	play	VB
cord-354050-kcn67stj	95	27	an	an	DT
cord-354050-kcn67stj	95	28	important	important	JJ
cord-354050-kcn67stj	95	29	role	role	NN
cord-354050-kcn67stj	95	30	in	in	IN
cord-354050-kcn67stj	95	31	whether	whether	IN
cord-354050-kcn67stj	95	32	or	or	CC
cord-354050-kcn67stj	95	33	not	not	RB
cord-354050-kcn67stj	95	34	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	95	35	and	and	CC
cord-354050-kcn67stj	95	36	related	related	JJ
cord-354050-kcn67stj	95	37	lentiviruses	lentiviruse	NNS
cord-354050-kcn67stj	95	38	are	be	VBP
cord-354050-kcn67stj	95	39	subject	subject	JJ
cord-354050-kcn67stj	95	40	to	to	IN
cord-354050-kcn67stj	95	41	inhibition	inhibition	NN
cord-354050-kcn67stj	95	42	by	by	IN
cord-354050-kcn67stj	95	43	IFITM	IFITM	NNP
cord-354050-kcn67stj	95	44	proteins	protein	NNS
cord-354050-kcn67stj	95	45	.	.	.
cord-354050-kcn67stj	96	1	A	a	DT
cord-354050-kcn67stj	96	2	report	report	NN
cord-354050-kcn67stj	96	3	taking	take	VBG
cord-354050-kcn67stj	96	4	advantage	advantage	NN
cord-354050-kcn67stj	96	5	of	of	IN
cord-354050-kcn67stj	96	6	retroviral	retroviral	JJ
cord-354050-kcn67stj	96	7	Env	Env	NNP
cord-354050-kcn67stj	96	8	pseudotyping	pseudotyping	NN
cord-354050-kcn67stj	96	9	provided	provide	VBD
cord-354050-kcn67stj	96	10	key	key	JJ
cord-354050-kcn67stj	96	11	insight	insight	NN
cord-354050-kcn67stj	96	12	into	into	IN
cord-354050-kcn67stj	96	13	viral	viral	JJ
cord-354050-kcn67stj	96	14	factors	factor	NNS
cord-354050-kcn67stj	96	15	that	that	WDT
cord-354050-kcn67stj	96	16	govern	govern	VBP
cord-354050-kcn67stj	96	17	susceptibility	susceptibility	NN
cord-354050-kcn67stj	96	18	and	and	CC
cord-354050-kcn67stj	96	19	resistance	resistance	NN
cord-354050-kcn67stj	96	20	.	.	.
cord-354050-kcn67stj	97	1	The	the	DT
cord-354050-kcn67stj	97	2	authors	author	NNS
cord-354050-kcn67stj	97	3	showed	show	VBD
cord-354050-kcn67stj	97	4	that	that	IN
cord-354050-kcn67stj	97	5	one	one	PRP
cord-354050-kcn67stj	97	6	can	can	MD
cord-354050-kcn67stj	97	7	decrease	decrease	VB
cord-354050-kcn67stj	97	8	sensitivity	sensitivity	NN
cord-354050-kcn67stj	97	9	to	to	IN
cord-354050-kcn67stj	97	10	IFITM	ifitm	NN
cord-354050-kcn67stj	97	11	proteins	protein	NNS
cord-354050-kcn67stj	97	12	by	by	IN
cord-354050-kcn67stj	97	13	increasing	increase	VBG
cord-354050-kcn67stj	97	14	amounts	amount	NNS
cord-354050-kcn67stj	97	15	of	of	IN
cord-354050-kcn67stj	97	16	lentiviral	lentiviral	JJ
cord-354050-kcn67stj	97	17	Env	Env	NNP
cord-354050-kcn67stj	97	18	incorporated	incorporate	VBN
cord-354050-kcn67stj	97	19	into	into	IN
cord-354050-kcn67stj	97	20	virions	virion	NNS
cord-354050-kcn67stj	97	21	[	[	-LRB-
cord-354050-kcn67stj	97	22	47	47	CD
cord-354050-kcn67stj	97	23	]	]	-RRB-
cord-354050-kcn67stj	97	24	.	.	.
cord-354050-kcn67stj	98	1	However	however	RB
cord-354050-kcn67stj	98	2	,	,	,
cord-354050-kcn67stj	98	3	they	-PRON-	PRP
cord-354050-kcn67stj	98	4	pointed	point	VBD
cord-354050-kcn67stj	98	5	out	out	RP
cord-354050-kcn67stj	98	6	that	that	IN
cord-354050-kcn67stj	98	7	the	the	DT
cord-354050-kcn67stj	98	8	capsid	capsid	JJ
cord-354050-kcn67stj	98	9	core	core	NN
cord-354050-kcn67stj	98	10	(	(	-LRB-
cord-354050-kcn67stj	98	11	vector	vector	NN
cord-354050-kcn67stj	98	12	)	)	-RRB-
cord-354050-kcn67stj	98	13	is	be	VBZ
cord-354050-kcn67stj	98	14	also	also	RB
cord-354050-kcn67stj	98	15	a	a	DT
cord-354050-kcn67stj	98	16	determinant	determinant	NN
cord-354050-kcn67stj	98	17	,	,	,
cord-354050-kcn67stj	98	18	indicating	indicate	VBG
cord-354050-kcn67stj	98	19	that	that	IN
cord-354050-kcn67stj	98	20	the	the	DT
cord-354050-kcn67stj	98	21	structure	structure	NN
cord-354050-kcn67stj	98	22	of	of	IN
cord-354050-kcn67stj	98	23	the	the	DT
cord-354050-kcn67stj	98	24	viruslike	viruslike	JJ
cord-354050-kcn67stj	98	25	particle	particle	NN
cord-354050-kcn67stj	98	26	and/or	and/or	CC
cord-354050-kcn67stj	98	27	its	-PRON-	PRP$
cord-354050-kcn67stj	98	28	coordination	coordination	NN
cord-354050-kcn67stj	98	29	with	with	IN
cord-354050-kcn67stj	98	30	Env	Env	NNP
cord-354050-kcn67stj	98	31	also	also	RB
cord-354050-kcn67stj	98	32	affects	affect	VBZ
cord-354050-kcn67stj	98	33	the	the	DT
cord-354050-kcn67stj	98	34	degree	degree	NN
cord-354050-kcn67stj	98	35	of	of	IN
cord-354050-kcn67stj	98	36	restriction	restriction	NN
cord-354050-kcn67stj	98	37	.	.	.
cord-354050-kcn67stj	99	1	Another	another	DT
cord-354050-kcn67stj	99	2	study	study	NN
cord-354050-kcn67stj	99	3	corroborated	corroborate	VBD
cord-354050-kcn67stj	99	4	the	the	DT
cord-354050-kcn67stj	99	5	importance	importance	NN
cord-354050-kcn67stj	99	6	of	of	IN
cord-354050-kcn67stj	99	7	Env	Env	NNP
cord-354050-kcn67stj	99	8	with	with	IN
cord-354050-kcn67stj	99	9	regards	regard	NNS
cord-354050-kcn67stj	99	10	to	to	IN
cord-354050-kcn67stj	99	11	inhibition	inhibition	NN
cord-354050-kcn67stj	99	12	by	by	IN
cord-354050-kcn67stj	99	13	IFITM	IFITM	NNP
cord-354050-kcn67stj	99	14	proteins	protein	NNS
cord-354050-kcn67stj	99	15	,	,	,
cord-354050-kcn67stj	99	16	this	this	DT
cord-354050-kcn67stj	99	17	time	time	NN
cord-354050-kcn67stj	99	18	via	via	IN
cord-354050-kcn67stj	99	19	examination	examination	NN
cord-354050-kcn67stj	99	20	of	of	IN
cord-354050-kcn67stj	99	21	patient	patient	NN
cord-354050-kcn67stj	99	22	-	-	HYPH
cord-354050-kcn67stj	99	23	derived	derive	VBN
cord-354050-kcn67stj	99	24	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	99	25	clones	clone	NNS
cord-354050-kcn67stj	99	26	known	know	VBN
cord-354050-kcn67stj	99	27	as	as	IN
cord-354050-kcn67stj	99	28	transmitted	transmit	VBN
cord-354050-kcn67stj	99	29	/	/	SYM
cord-354050-kcn67stj	99	30	founder	founder	NN
cord-354050-kcn67stj	99	31	(	(	-LRB-
cord-354050-kcn67stj	99	32	TF	TF	NNP
cord-354050-kcn67stj	99	33	)	)	-RRB-
cord-354050-kcn67stj	99	34	strains	strain	VBZ
cord-354050-kcn67stj	99	35	[	[	-LRB-
cord-354050-kcn67stj	99	36	48	48	CD
cord-354050-kcn67stj	99	37	]	]	-RRB-
cord-354050-kcn67stj	99	38	.	.	.
cord-354050-kcn67stj	100	1	These	these	DT
cord-354050-kcn67stj	100	2	viral	viral	JJ
cord-354050-kcn67stj	100	3	variants	variant	NNS
cord-354050-kcn67stj	100	4	represent	represent	VBP
cord-354050-kcn67stj	100	5	a	a	DT
cord-354050-kcn67stj	100	6	close	close	JJ
cord-354050-kcn67stj	100	7	approximation	approximation	NN
cord-354050-kcn67stj	100	8	of	of	IN
cord-354050-kcn67stj	100	9	the	the	DT
cord-354050-kcn67stj	100	10	viral	viral	JJ
cord-354050-kcn67stj	100	11	sequence	sequence	NN
cord-354050-kcn67stj	100	12	that	that	WDT
cord-354050-kcn67stj	100	13	seeds	seed	VBZ
cord-354050-kcn67stj	100	14	infection	infection	NN
cord-354050-kcn67stj	100	15	in	in	IN
cord-354050-kcn67stj	100	16	a	a	DT
cord-354050-kcn67stj	100	17	newlyinfected	newlyinfected	JJ
cord-354050-kcn67stj	100	18	individual	individual	NN
cord-354050-kcn67stj	100	19	,	,	,
cord-354050-kcn67stj	100	20	and	and	CC
cord-354050-kcn67stj	100	21	they	-PRON-	PRP
cord-354050-kcn67stj	100	22	tend	tend	VBP
cord-354050-kcn67stj	100	23	to	to	TO
cord-354050-kcn67stj	100	24	utilize	utilize	VB
cord-354050-kcn67stj	100	25	a	a	DT
cord-354050-kcn67stj	100	26	specific	specific	JJ
cord-354050-kcn67stj	100	27	co	co	JJ
cord-354050-kcn67stj	100	28	-	-	NN
cord-354050-kcn67stj	100	29	receptor	receptor	NN
cord-354050-kcn67stj	100	30	on	on	IN
cord-354050-kcn67stj	100	31	the	the	DT
cord-354050-kcn67stj	100	32	cell	cell	NN
cord-354050-kcn67stj	100	33	surface	surface	NN
cord-354050-kcn67stj	100	34	known	know	VBN
cord-354050-kcn67stj	100	35	as	as	IN
cord-354050-kcn67stj	100	36	CCR5	CCR5	NNP
cord-354050-kcn67stj	100	37	.	.	.
cord-354050-kcn67stj	101	1	Here	here	RB
cord-354050-kcn67stj	101	2	,	,	,
cord-354050-kcn67stj	101	3	it	-PRON-	PRP
cord-354050-kcn67stj	101	4	was	be	VBD
cord-354050-kcn67stj	101	5	revealed	reveal	VBN
cord-354050-kcn67stj	101	6	that	that	IN
cord-354050-kcn67stj	101	7	the	the	DT
cord-354050-kcn67stj	101	8	sensitivity	sensitivity	NN
cord-354050-kcn67stj	101	9	of	of	IN
cord-354050-kcn67stj	101	10	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	101	11	entry	entry	NN
cord-354050-kcn67stj	101	12	to	to	IN
cord-354050-kcn67stj	101	13	IFITMmediated	ifitmmediate	VBN
cord-354050-kcn67stj	101	14	restriction	restriction	NN
cord-354050-kcn67stj	101	15	depends	depend	VBZ
cord-354050-kcn67stj	101	16	on	on	IN
cord-354050-kcn67stj	101	17	coreceptor	coreceptor	NN
cord-354050-kcn67stj	101	18	usage	usage	NN
cord-354050-kcn67stj	101	19	and	and	CC
cord-354050-kcn67stj	101	20	the	the	DT
cord-354050-kcn67stj	101	21	subcellular	subcellular	JJ
cord-354050-kcn67stj	101	22	localization	localization	NN
cord-354050-kcn67stj	101	23	of	of	IN
cord-354050-kcn67stj	101	24	IFITM	IFITM	NNP
cord-354050-kcn67stj	101	25	in	in	IN
cord-354050-kcn67stj	101	26	the	the	DT
cord-354050-kcn67stj	101	27	host	host	NN
cord-354050-kcn67stj	101	28	cell	cell	NN
cord-354050-kcn67stj	101	29	.	.	.
cord-354050-kcn67stj	102	1	CXCR4-tropic	CXCR4-tropic	NNP
cord-354050-kcn67stj	102	2	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	102	3	strains	strain	NNS
cord-354050-kcn67stj	102	4	were	be	VBD
cord-354050-kcn67stj	102	5	shown	show	VBN
cord-354050-kcn67stj	102	6	to	to	TO
cord-354050-kcn67stj	102	7	exhibit	exhibit	VB
cord-354050-kcn67stj	102	8	sensitivity	sensitivity	NN
cord-354050-kcn67stj	102	9	to	to	IN
cord-354050-kcn67stj	102	10	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	102	11	and	and	CC
cord-354050-kcn67stj	102	12	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	102	13	,	,	,
cord-354050-kcn67stj	102	14	which	which	WDT
cord-354050-kcn67stj	102	15	are	be	VBP
cord-354050-kcn67stj	102	16	mostly	mostly	RB
cord-354050-kcn67stj	102	17	localized	localize	VBN
cord-354050-kcn67stj	102	18	to	to	IN
cord-354050-kcn67stj	102	19	endolysosomes	endolysosome	NNS
cord-354050-kcn67stj	102	20	,	,	,
cord-354050-kcn67stj	102	21	while	while	IN
cord-354050-kcn67stj	102	22	CCR5-tropic	CCR5-tropic	NNP
cord-354050-kcn67stj	102	23	strains	strain	NNS
cord-354050-kcn67stj	102	24	were	be	VBD
cord-354050-kcn67stj	102	25	sensitive	sensitive	JJ
cord-354050-kcn67stj	102	26	to	to	IN
cord-354050-kcn67stj	102	27	IFITM1	IFITM1	NNP
cord-354050-kcn67stj	102	28	at	at	IN
cord-354050-kcn67stj	102	29	the	the	DT
cord-354050-kcn67stj	102	30	plasma	plasma	NN
cord-354050-kcn67stj	102	31	membrane	membrane	NN
cord-354050-kcn67stj	102	32	.	.	.
cord-354050-kcn67stj	103	1	This	this	DT
cord-354050-kcn67stj	103	2	differential	differential	JJ
cord-354050-kcn67stj	103	3	outcome	outcome	NN
cord-354050-kcn67stj	103	4	suggests	suggest	VBZ
cord-354050-kcn67stj	103	5	that	that	IN
cord-354050-kcn67stj	103	6	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	103	7	fusion	fusion	NN
cord-354050-kcn67stj	103	8	may	may	MD
cord-354050-kcn67stj	103	9	occur	occur	VB
cord-354050-kcn67stj	103	10	in	in	IN
cord-354050-kcn67stj	103	11	endosomes	endosome	NNS
cord-354050-kcn67stj	103	12	or	or	CC
cord-354050-kcn67stj	103	13	at	at	IN
cord-354050-kcn67stj	103	14	the	the	DT
cord-354050-kcn67stj	103	15	plasma	plasma	NN
cord-354050-kcn67stj	103	16	membrane	membrane	NN
cord-354050-kcn67stj	103	17	depending	depend	VBG
cord-354050-kcn67stj	103	18	on	on	IN
cord-354050-kcn67stj	103	19	which	which	WDT
cord-354050-kcn67stj	103	20	virus	virus	NN
cord-354050-kcn67stj	103	21	coreceptor	coreceptor	NN
cord-354050-kcn67stj	103	22	is	be	VBZ
cord-354050-kcn67stj	103	23	engaged	engage	VBN
cord-354050-kcn67stj	103	24	at	at	IN
cord-354050-kcn67stj	103	25	the	the	DT
cord-354050-kcn67stj	103	26	cell	cell	NN
cord-354050-kcn67stj	103	27	surface	surface	NN
cord-354050-kcn67stj	103	28	.	.	.
cord-354050-kcn67stj	104	1	TF	TF	NNP
cord-354050-kcn67stj	104	2	strains	strain	NNS
cord-354050-kcn67stj	104	3	are	be	VBP
cord-354050-kcn67stj	104	4	relatively	relatively	RB
cord-354050-kcn67stj	104	5	resistant	resistant	JJ
cord-354050-kcn67stj	104	6	to	to	IN
cord-354050-kcn67stj	104	7	IFITM	ifitm	NN
cord-354050-kcn67stj	104	8	-	-	HYPH
cord-354050-kcn67stj	104	9	mediated	mediate	VBN
cord-354050-kcn67stj	104	10	restriction	restriction	NN
cord-354050-kcn67stj	104	11	,	,	,
cord-354050-kcn67stj	104	12	yet	yet	CC
cord-354050-kcn67stj	104	13	matched	match	VBN
cord-354050-kcn67stj	104	14	viral	viral	JJ
cord-354050-kcn67stj	104	15	clones	clone	NNS
cord-354050-kcn67stj	104	16	derived	derive	VBN
cord-354050-kcn67stj	104	17	6	6	CD
cord-354050-kcn67stj	104	18	months	month	NNS
cord-354050-kcn67stj	104	19	following	follow	VBG
cord-354050-kcn67stj	104	20	initial	initial	JJ
cord-354050-kcn67stj	104	21	infection	infection	NN
cord-354050-kcn67stj	104	22	exhibited	exhibit	VBD
cord-354050-kcn67stj	104	23	a	a	DT
cord-354050-kcn67stj	104	24	gain	gain	NN
cord-354050-kcn67stj	104	25	of	of	IN
cord-354050-kcn67stj	104	26	sensitivity	sensitivity	NN
cord-354050-kcn67stj	104	27	to	to	IN
cord-354050-kcn67stj	104	28	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	104	29	and	and	CC
cord-354050-kcn67stj	104	30	IFITM3	IFITM3	''
cord-354050-kcn67stj	104	31	[	[	-LRB-
cord-354050-kcn67stj	104	32	49	49	CD
cord-354050-kcn67stj	104	33	]	]	-RRB-
cord-354050-kcn67stj	104	34	.	.	.
cord-354050-kcn67stj	105	1	This	this	DT
cord-354050-kcn67stj	105	2	finding	finding	NN
cord-354050-kcn67stj	105	3	suggests	suggest	VBZ
cord-354050-kcn67stj	105	4	that	that	IN
cord-354050-kcn67stj	105	5	founder	founder	NN
cord-354050-kcn67stj	105	6	viruses	virus	NNS
cord-354050-kcn67stj	105	7	enter	enter	VBP
cord-354050-kcn67stj	105	8	cells	cell	NNS
cord-354050-kcn67stj	105	9	at	at	IN
cord-354050-kcn67stj	105	10	the	the	DT
cord-354050-kcn67stj	105	11	plasma	plasma	NN
cord-354050-kcn67stj	105	12	membrane	membrane	NN
cord-354050-kcn67stj	105	13	,	,	,
cord-354050-kcn67stj	105	14	while	while	IN
cord-354050-kcn67stj	105	15	viruses	virus	NNS
cord-354050-kcn67stj	105	16	isolated	isolate	VBN
cord-354050-kcn67stj	105	17	at	at	IN
cord-354050-kcn67stj	105	18	later	later	JJ
cord-354050-kcn67stj	105	19	stages	stage	NNS
cord-354050-kcn67stj	105	20	of	of	IN
cord-354050-kcn67stj	105	21	infection	infection	NN
cord-354050-kcn67stj	105	22	might	may	MD
cord-354050-kcn67stj	105	23	increasingly	increasingly	RB
cord-354050-kcn67stj	105	24	rely	rely	VB
cord-354050-kcn67stj	105	25	on	on	IN
cord-354050-kcn67stj	105	26	endosomal	endosomal	NNP
cord-354050-kcn67stj	105	27	entry	entry	NN
cord-354050-kcn67stj	105	28	.	.	.
cord-354050-kcn67stj	106	1	However	however	RB
cord-354050-kcn67stj	106	2	,	,	,
cord-354050-kcn67stj	106	3	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	106	4	and	and	CC
cord-354050-kcn67stj	106	5	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	106	6	also	also	RB
cord-354050-kcn67stj	106	7	transit	transit	VB
cord-354050-kcn67stj	106	8	to	to	IN
cord-354050-kcn67stj	106	9	the	the	DT
cord-354050-kcn67stj	106	10	plasma	plasma	NN
cord-354050-kcn67stj	106	11	membrane	membrane	NN
cord-354050-kcn67stj	106	12	before	before	IN
cord-354050-kcn67stj	106	13	endocytosis	endocytosis	NN
cord-354050-kcn67stj	106	14	,	,	,
cord-354050-kcn67stj	106	15	and	and	CC
cord-354050-kcn67stj	106	16	thus	thus	RB
cord-354050-kcn67stj	106	17	the	the	DT
cord-354050-kcn67stj	106	18	varying	vary	VBG
cord-354050-kcn67stj	106	19	sensitivity	sensitivity	NN
cord-354050-kcn67stj	106	20	of	of	IN
cord-354050-kcn67stj	106	21	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	106	22	strains	strain	NNS
cord-354050-kcn67stj	106	23	may	may	MD
cord-354050-kcn67stj	106	24	result	result	VB
cord-354050-kcn67stj	106	25	from	from	IN
cord-354050-kcn67stj	106	26	fusion	fusion	NN
cord-354050-kcn67stj	106	27	at	at	IN
cord-354050-kcn67stj	106	28	different	different	JJ
cord-354050-kcn67stj	106	29	plasma	plasma	NN
cord-354050-kcn67stj	106	30	membrane	membrane	NN
cord-354050-kcn67stj	106	31	microdomains	microdomain	NNS
cord-354050-kcn67stj	106	32	.	.	.
cord-354050-kcn67stj	107	1	Furthermore	furthermore	RB
cord-354050-kcn67stj	107	2	,	,	,
cord-354050-kcn67stj	107	3	the	the	DT
cord-354050-kcn67stj	107	4	authors	author	NNS
cord-354050-kcn67stj	107	5	show	show	VBP
cord-354050-kcn67stj	107	6	that	that	IN
cord-354050-kcn67stj	107	7	the	the	DT
cord-354050-kcn67stj	107	8	site	site	NN
cord-354050-kcn67stj	107	9	of	of	IN
cord-354050-kcn67stj	107	10	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	107	11	entry	entry	NN
cord-354050-kcn67stj	107	12	,	,	,
cord-354050-kcn67stj	107	13	as	as	IN
cord-354050-kcn67stj	107	14	inferred	infer	VBN
cord-354050-kcn67stj	107	15	by	by	IN
cord-354050-kcn67stj	107	16	sensitivity	sensitivity	NN
cord-354050-kcn67stj	107	17	to	to	IN
cord-354050-kcn67stj	107	18	IFITM	IFITM	NNP
cord-354050-kcn67stj	107	19	proteins	protein	NNS
cord-354050-kcn67stj	107	20	,	,	,
cord-354050-kcn67stj	107	21	may	may	MD
cord-354050-kcn67stj	107	22	also	also	RB
cord-354050-kcn67stj	107	23	depend	depend	VB
cord-354050-kcn67stj	107	24	on	on	IN
cord-354050-kcn67stj	107	25	cell	cell	NN
cord-354050-kcn67stj	107	26	surface	surface	NN
cord-354050-kcn67stj	107	27	levels	level	NNS
cord-354050-kcn67stj	107	28	of	of	IN
cord-354050-kcn67stj	107	29	CD4	CD4	NNP
cord-354050-kcn67stj	107	30	.	.	.
cord-354050-kcn67stj	108	1	Another	another	DT
cord-354050-kcn67stj	108	2	report	report	NN
cord-354050-kcn67stj	108	3	reinforced	reinforce	VBD
cord-354050-kcn67stj	108	4	the	the	DT
cord-354050-kcn67stj	108	5	link	link	NN
cord-354050-kcn67stj	108	6	between	between	IN
cord-354050-kcn67stj	108	7	IFITM	IFITM	NNP
cord-354050-kcn67stj	108	8	and	and	CC
cord-354050-kcn67stj	108	9	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	108	10	entry	entry	NN
cord-354050-kcn67stj	108	11	by	by	IN
cord-354050-kcn67stj	108	12	demonstrating	demonstrate	VBG
cord-354050-kcn67stj	108	13	that	that	IN
cord-354050-kcn67stj	108	14	CXCR4-tropic	CXCR4-tropic	NNP
cord-354050-kcn67stj	108	15	,	,	,
cord-354050-kcn67stj	109	1	but	but	CC
cord-354050-kcn67stj	109	2	not	not	RB
cord-354050-kcn67stj	109	3	CCR5-tropic	CCR5-tropic	NNP
cord-354050-kcn67stj	109	4	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	109	5	,	,	,
cord-354050-kcn67stj	109	6	is	be	VBZ
cord-354050-kcn67stj	109	7	hypersensitive	hypersensitive	JJ
cord-354050-kcn67stj	109	8	to	to	IN
cord-354050-kcn67stj	109	9	a	a	DT
cord-354050-kcn67stj	109	10	splice	splice	NN
cord-354050-kcn67stj	109	11	variant	variant	NN
cord-354050-kcn67stj	109	12	of	of	IN
cord-354050-kcn67stj	109	13	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	109	14	lacking	lack	VBG
cord-354050-kcn67stj	109	15	the	the	DT
cord-354050-kcn67stj	109	16	amino	amino	NN
cord-354050-kcn67stj	109	17	terminus	terminus	NN
cord-354050-kcn67stj	109	18	.	.	.
cord-354050-kcn67stj	110	1	Notably	notably	RB
cord-354050-kcn67stj	110	2	,	,	,
cord-354050-kcn67stj	110	3	this	this	DT
cord-354050-kcn67stj	110	4	IFITM	IFITM	NNP
cord-354050-kcn67stj	110	5	variant	variant	NN
cord-354050-kcn67stj	110	6	is	be	VBZ
cord-354050-kcn67stj	110	7	especially	especially	RB
cord-354050-kcn67stj	110	8	abundant	abundant	JJ
cord-354050-kcn67stj	110	9	in	in	IN
cord-354050-kcn67stj	110	10	primary	primary	JJ
cord-354050-kcn67stj	110	11	human	human	JJ
cord-354050-kcn67stj	110	12	cells	cell	NNS
cord-354050-kcn67stj	111	1	(	(	-LRB-
cord-354050-kcn67stj	111	2	CD4	CD4	NNP
cord-354050-kcn67stj	111	3	+	+	CC
cord-354050-kcn67stj	111	4	T	t	NN
cord-354050-kcn67stj	111	5	cells	cell	NNS
cord-354050-kcn67stj	111	6	and	and	CC
cord-354050-kcn67stj	111	7	monocytes	monocyte	NNS
cord-354050-kcn67stj	111	8	)	)	-RRB-
cord-354050-kcn67stj	111	9	that	that	WDT
cord-354050-kcn67stj	111	10	serve	serve	VBP
cord-354050-kcn67stj	111	11	as	as	IN
cord-354050-kcn67stj	111	12	targets	target	NNS
cord-354050-kcn67stj	111	13	for	for	IN
cord-354050-kcn67stj	111	14	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	111	15	infection	infection	NN
cord-354050-kcn67stj	111	16	in	in	IN
cord-354050-kcn67stj	111	17	vivo	vivo	NN
cord-354050-kcn67stj	111	18	[	[	-LRB-
cord-354050-kcn67stj	111	19	50	50	CD
cord-354050-kcn67stj	111	20	]	]	-RRB-
cord-354050-kcn67stj	111	21	.	.	.
cord-354050-kcn67stj	112	1	Together	together	RB
cord-354050-kcn67stj	112	2	,	,	,
cord-354050-kcn67stj	112	3	these	these	DT
cord-354050-kcn67stj	112	4	recent	recent	JJ
cord-354050-kcn67stj	112	5	data	datum	NNS
cord-354050-kcn67stj	112	6	suggest	suggest	VBP
cord-354050-kcn67stj	112	7	that	that	IN
cord-354050-kcn67stj	112	8	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	112	9	and	and	CC
cord-354050-kcn67stj	112	10	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	112	11	may	may	MD
cord-354050-kcn67stj	112	12	be	be	VB
cord-354050-kcn67stj	112	13	major	major	JJ
cord-354050-kcn67stj	112	14	selective	selective	JJ
cord-354050-kcn67stj	112	15	pressures	pressure	NNS
cord-354050-kcn67stj	112	16	responsible	responsible	JJ
cord-354050-kcn67stj	112	17	for	for	IN
cord-354050-kcn67stj	112	18	the	the	DT
cord-354050-kcn67stj	112	19	use	use	NN
cord-354050-kcn67stj	112	20	of	of	IN
cord-354050-kcn67stj	112	21	CCR5	CCR5	NNP
cord-354050-kcn67stj	112	22	during	during	IN
cord-354050-kcn67stj	112	23	primary	primary	JJ
cord-354050-kcn67stj	112	24	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	112	25	infection	infection	NN
cord-354050-kcn67stj	112	26	.	.	.
cord-354050-kcn67stj	113	1	In	in	IN
cord-354050-kcn67stj	113	2	addition	addition	NN
cord-354050-kcn67stj	113	3	to	to	IN
cord-354050-kcn67stj	113	4	restricting	restrict	VBG
cord-354050-kcn67stj	113	5	virus	virus	NN
cord-354050-kcn67stj	113	6	entry	entry	NN
cord-354050-kcn67stj	113	7	,	,	,
cord-354050-kcn67stj	113	8	recent	recent	JJ
cord-354050-kcn67stj	113	9	findings	finding	NNS
cord-354050-kcn67stj	113	10	indicate	indicate	VBP
cord-354050-kcn67stj	113	11	that	that	IN
cord-354050-kcn67stj	113	12	IFITM	IFITM	NNP
cord-354050-kcn67stj	113	13	proteins	protein	NNS
cord-354050-kcn67stj	113	14	perform	perform	VBP
cord-354050-kcn67stj	113	15	antiviral	antiviral	JJ
cord-354050-kcn67stj	113	16	functions	function	NNS
cord-354050-kcn67stj	113	17	impacting	impact	VBG
cord-354050-kcn67stj	113	18	late	late	JJ
cord-354050-kcn67stj	113	19	stages	stage	NNS
cord-354050-kcn67stj	113	20	of	of	IN
cord-354050-kcn67stj	113	21	the	the	DT
cord-354050-kcn67stj	113	22	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	113	23	life	life	NN
cord-354050-kcn67stj	113	24	cycle	cycle	NN
cord-354050-kcn67stj	113	25	.	.	.
cord-354050-kcn67stj	114	1	In	in	IN
cord-354050-kcn67stj	114	2	contrast	contrast	NN
cord-354050-kcn67stj	114	3	to	to	IN
cord-354050-kcn67stj	114	4	previous	previous	JJ
cord-354050-kcn67stj	114	5	strategies	strategy	NNS
cord-354050-kcn67stj	114	6	in	in	IN
cord-354050-kcn67stj	114	7	which	which	WDT
cord-354050-kcn67stj	114	8	infections	infection	NNS
cord-354050-kcn67stj	114	9	were	be	VBD
cord-354050-kcn67stj	114	10	launched	launch	VBN
cord-354050-kcn67stj	114	11	using	use	VBG
cord-354050-kcn67stj	114	12	only	only	JJ
cord-354050-kcn67stj	114	13	cell	cell	NN
cord-354050-kcn67stj	114	14	-	-	HYPH
cord-354050-kcn67stj	114	15	free	free	JJ
cord-354050-kcn67stj	114	16	virus	virus	NN
cord-354050-kcn67stj	114	17	preparations	preparation	NNS
cord-354050-kcn67stj	114	18	,	,	,
cord-354050-kcn67stj	114	19	the	the	DT
cord-354050-kcn67stj	114	20	use	use	NN
cord-354050-kcn67stj	114	21	of	of	IN
cord-354050-kcn67stj	114	22	cell	cell	NN
cord-354050-kcn67stj	114	23	coculture	coculture	NN
cord-354050-kcn67stj	114	24	experiments	experiment	NNS
cord-354050-kcn67stj	114	25	using	use	VBG
cord-354050-kcn67stj	114	26	infected	infected	JJ
cord-354050-kcn67stj	114	27	cells	cell	NNS
cord-354050-kcn67stj	114	28	(	(	-LRB-
cord-354050-kcn67stj	114	29	donors	donor	NNS
cord-354050-kcn67stj	114	30	)	)	-RRB-
cord-354050-kcn67stj	114	31	and	and	CC
cord-354050-kcn67stj	114	32	uninfected	uninfected	JJ
cord-354050-kcn67stj	114	33	cells	cell	NNS
cord-354050-kcn67stj	114	34	(	(	-LRB-
cord-354050-kcn67stj	114	35	targets	target	NNS
cord-354050-kcn67stj	114	36	)	)	-RRB-
cord-354050-kcn67stj	114	37	revealed	reveal	VBD
cord-354050-kcn67stj	114	38	new	new	JJ
cord-354050-kcn67stj	114	39	antiviral	antiviral	JJ
cord-354050-kcn67stj	114	40	functions	function	NNS
cord-354050-kcn67stj	114	41	[	[	-LRB-
cord-354050-kcn67stj	114	42	51	51	CD
cord-354050-kcn67stj	114	43	]	]	-RRB-
cord-354050-kcn67stj	114	44	.	.	.
cord-354050-kcn67stj	115	1	We	-PRON-	PRP
cord-354050-kcn67stj	115	2	found	find	VBD
cord-354050-kcn67stj	115	3	that	that	IN
cord-354050-kcn67stj	115	4	IFITM	IFITM	NNP
cord-354050-kcn67stj	115	5	overexpression	overexpression	NN
cord-354050-kcn67stj	115	6	in	in	IN
cord-354050-kcn67stj	115	7	targets	target	NNS
cord-354050-kcn67stj	115	8	had	have	VBD
cord-354050-kcn67stj	115	9	little	little	JJ
cord-354050-kcn67stj	115	10	to	to	IN
cord-354050-kcn67stj	115	11	no	no	DT
cord-354050-kcn67stj	115	12	consequence	consequence	NN
cord-354050-kcn67stj	115	13	for	for	IN
cord-354050-kcn67stj	115	14	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	115	15	transmission	transmission	NN
cord-354050-kcn67stj	115	16	and	and	CC
cord-354050-kcn67stj	115	17	spread	spread	VBD
cord-354050-kcn67stj	115	18	in	in	IN
cord-354050-kcn67stj	115	19	this	this	DT
cord-354050-kcn67stj	115	20	context	context	NN
cord-354050-kcn67stj	115	21	,	,	,
cord-354050-kcn67stj	115	22	while	while	IN
cord-354050-kcn67stj	115	23	,	,	,
cord-354050-kcn67stj	115	24	surprisingly	surprisingly	RB
cord-354050-kcn67stj	115	25	,	,	,
cord-354050-kcn67stj	115	26	overexpression	overexpression	NN
cord-354050-kcn67stj	115	27	in	in	IN
cord-354050-kcn67stj	115	28	donor	donor	NN
cord-354050-kcn67stj	115	29	cells	cell	NNS
cord-354050-kcn67stj	115	30	led	lead	VBD
cord-354050-kcn67stj	115	31	to	to	IN
cord-354050-kcn67stj	115	32	potent	potent	JJ
cord-354050-kcn67stj	115	33	decreases	decrease	NNS
cord-354050-kcn67stj	115	34	[	[	-LRB-
cord-354050-kcn67stj	115	35	51	51	CD
cord-354050-kcn67stj	115	36	]	]	-RRB-
cord-354050-kcn67stj	115	37	.	.	.
cord-354050-kcn67stj	116	1	Further	further	JJ
cord-354050-kcn67stj	116	2	experiments	experiment	NNS
cord-354050-kcn67stj	116	3	showed	show	VBD
cord-354050-kcn67stj	116	4	that	that	IN
cord-354050-kcn67stj	116	5	the	the	DT
cord-354050-kcn67stj	116	6	block	block	NN
cord-354050-kcn67stj	116	7	to	to	IN
cord-354050-kcn67stj	116	8	virus	virus	NN
cord-354050-kcn67stj	116	9	spread	spread	NN
cord-354050-kcn67stj	116	10	is	be	VBZ
cord-354050-kcn67stj	116	11	attributed	attribute	VBN
cord-354050-kcn67stj	116	12	to	to	IN
cord-354050-kcn67stj	116	13	an	an	DT
cord-354050-kcn67stj	116	14	inhibition	inhibition	NN
cord-354050-kcn67stj	116	15	of	of	IN
cord-354050-kcn67stj	116	16	virion	virion	NN
cord-354050-kcn67stj	116	17	infectivity	infectivity	NN
cord-354050-kcn67stj	116	18	,	,	,
cord-354050-kcn67stj	116	19	with	with	IN
cord-354050-kcn67stj	116	20	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	116	21	exhibiting	exhibit	VBG
cord-354050-kcn67stj	116	22	the	the	DT
cord-354050-kcn67stj	116	23	most	most	RBS
cord-354050-kcn67stj	116	24	potent	potent	JJ
cord-354050-kcn67stj	116	25	restriction	restriction	NN
cord-354050-kcn67stj	116	26	.	.	.
cord-354050-kcn67stj	117	1	Virus	virus	NN
cord-354050-kcn67stj	117	2	-	-	HYPH
cord-354050-kcn67stj	117	3	cell	cell	NN
cord-354050-kcn67stj	117	4	fusions	fusion	NNS
cord-354050-kcn67stj	117	5	assays	assay	NNS
cord-354050-kcn67stj	117	6	showed	show	VBD
cord-354050-kcn67stj	117	7	that	that	IN
cord-354050-kcn67stj	117	8	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	117	9	virions	virion	NNS
cord-354050-kcn67stj	117	10	produced	produce	VBN
cord-354050-kcn67stj	117	11	in	in	IN
cord-354050-kcn67stj	117	12	the	the	DT
cord-354050-kcn67stj	117	13	presence	presence	NN
cord-354050-kcn67stj	117	14	of	of	IN
cord-354050-kcn67stj	117	15	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	117	16	are	be	VBP
cord-354050-kcn67stj	117	17	less	less	RBR
cord-354050-kcn67stj	117	18	fusogenic	fusogenic	JJ
cord-354050-kcn67stj	117	19	when	when	WRB
cord-354050-kcn67stj	117	20	incubated	incubate	VBN
cord-354050-kcn67stj	117	21	with	with	IN
cord-354050-kcn67stj	117	22	fresh	fresh	JJ
cord-354050-kcn67stj	117	23	target	target	NN
cord-354050-kcn67stj	117	24	cells	cell	NNS
cord-354050-kcn67stj	117	25	,	,	,
cord-354050-kcn67stj	117	26	and	and	CC
cord-354050-kcn67stj	117	27	assessment	assessment	NN
cord-354050-kcn67stj	117	28	of	of	IN
cord-354050-kcn67stj	117	29	virion	virion	NN
cord-354050-kcn67stj	117	30	content	content	NN
cord-354050-kcn67stj	117	31	indicated	indicate	VBD
cord-354050-kcn67stj	117	32	that	that	IN
cord-354050-kcn67stj	117	33	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	117	34	incorporates	incorporate	VBZ
cord-354050-kcn67stj	117	35	into	into	IN
cord-354050-kcn67stj	117	36	the	the	DT
cord-354050-kcn67stj	117	37	viral	viral	JJ
cord-354050-kcn67stj	117	38	lipid	lipid	NN
cord-354050-kcn67stj	117	39	bilayer	bilayer	NN
cord-354050-kcn67stj	117	40	.	.	.
cord-354050-kcn67stj	118	1	This	this	DT
cord-354050-kcn67stj	118	2	antiviral	antiviral	JJ
cord-354050-kcn67stj	118	3	activity	activity	NN
cord-354050-kcn67stj	118	4	is	be	VBZ
cord-354050-kcn67stj	118	5	enhanced	enhance	VBN
cord-354050-kcn67stj	118	6	upon	upon	IN
cord-354050-kcn67stj	118	7	expression	expression	NN
cord-354050-kcn67stj	118	8	of	of	IN
cord-354050-kcn67stj	118	9	an	an	DT
cord-354050-kcn67stj	118	10	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	118	11	mutant	mutant	NN
cord-354050-kcn67stj	118	12	that	that	WDT
cord-354050-kcn67stj	118	13	is	be	VBZ
cord-354050-kcn67stj	118	14	defective	defective	JJ
cord-354050-kcn67stj	118	15	for	for	IN
cord-354050-kcn67stj	118	16	endocytosis	endocytosis	NN
cord-354050-kcn67stj	118	17	,	,	,
cord-354050-kcn67stj	118	18	indicating	indicate	VBG
cord-354050-kcn67stj	118	19	that	that	IN
cord-354050-kcn67stj	118	20	restriction	restriction	NN
cord-354050-kcn67stj	118	21	of	of	IN
cord-354050-kcn67stj	118	22	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	118	23	virion	virion	NN
cord-354050-kcn67stj	118	24	infectivity	infectivity	NN
cord-354050-kcn67stj	118	25	is	be	VBZ
cord-354050-kcn67stj	118	26	performed	perform	VBN
cord-354050-kcn67stj	118	27	at	at	IN
cord-354050-kcn67stj	118	28	the	the	DT
cord-354050-kcn67stj	118	29	plasma	plasma	NN
cord-354050-kcn67stj	118	30	membrane	membrane	NN
cord-354050-kcn67stj	118	31	[	[	-LRB-
cord-354050-kcn67stj	118	32	5	5	CD
cord-354050-kcn67stj	118	33	]	]	-RRB-
cord-354050-kcn67stj	118	34	.	.	.
cord-354050-kcn67stj	119	1	Two	two	CD
cord-354050-kcn67stj	119	2	other	other	JJ
cord-354050-kcn67stj	119	3	teams	team	NNS
cord-354050-kcn67stj	119	4	reported	report	VBD
cord-354050-kcn67stj	119	5	similar	similar	JJ
cord-354050-kcn67stj	119	6	findings	finding	NNS
cord-354050-kcn67stj	119	7	on	on	IN
cord-354050-kcn67stj	119	8	this	this	DT
cord-354050-kcn67stj	119	9	phenomenon	phenomenon	NN
cord-354050-kcn67stj	119	10	in	in	IN
cord-354050-kcn67stj	119	11	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	119	12	producing	produce	VBG
cord-354050-kcn67stj	119	13	cells	cell	NNS
cord-354050-kcn67stj	119	14	,	,	,
cord-354050-kcn67stj	119	15	with	with	IN
cord-354050-kcn67stj	119	16	one	one	CD
cord-354050-kcn67stj	119	17	adding	add	VBG
cord-354050-kcn67stj	119	18	a	a	DT
cord-354050-kcn67stj	119	19	layer	layer	NN
cord-354050-kcn67stj	119	20	of	of	IN
cord-354050-kcn67stj	119	21	mechanistic	mechanistic	JJ
cord-354050-kcn67stj	119	22	insight	insight	NN
cord-354050-kcn67stj	119	23	involving	involve	VBG
cord-354050-kcn67stj	119	24	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	119	25	Env	Env	NNP
cord-354050-kcn67stj	119	26	glycoprotein	glycoprotein	NN
cord-354050-kcn67stj	119	27	[	[	-LRB-
cord-354050-kcn67stj	119	28	52	52	CD
cord-354050-kcn67stj	119	29	]	]	-RRB-
cord-354050-kcn67stj	119	30	[	[	-LRB-
cord-354050-kcn67stj	119	31	53	53	CD
cord-354050-kcn67stj	119	32	]	]	-RRB-
cord-354050-kcn67stj	119	33	[	[	-LRB-
cord-354050-kcn67stj	119	34	54	54	CD
cord-354050-kcn67stj	119	35	]	]	-RRB-
cord-354050-kcn67stj	119	36	.	.	.
cord-354050-kcn67stj	120	1	Here	here	RB
cord-354050-kcn67stj	120	2	,	,	,
cord-354050-kcn67stj	120	3	the	the	DT
cord-354050-kcn67stj	120	4	production	production	NN
cord-354050-kcn67stj	120	5	of	of	IN
cord-354050-kcn67stj	120	6	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	120	7	particles	particle	NNS
cord-354050-kcn67stj	120	8	in	in	IN
cord-354050-kcn67stj	120	9	the	the	DT
cord-354050-kcn67stj	120	10	presence	presence	NN
cord-354050-kcn67stj	120	11	of	of	IN
cord-354050-kcn67stj	120	12	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	120	13	via	via	IN
cord-354050-kcn67stj	120	14	co	co	NN
cord-354050-kcn67stj	120	15	-	-	NN
cord-354050-kcn67stj	120	16	transfection	transfection	NN
cord-354050-kcn67stj	120	17	of	of	IN
cord-354050-kcn67stj	120	18	293	293	CD
cord-354050-kcn67stj	120	19	T	t	NN
cord-354050-kcn67stj	120	20	cells	cell	NNS
cord-354050-kcn67stj	120	21	resulted	result	VBD
cord-354050-kcn67stj	120	22	in	in	IN
cord-354050-kcn67stj	120	23	defects	defect	NNS
cord-354050-kcn67stj	120	24	in	in	IN
cord-354050-kcn67stj	120	25	Env	Env	NNP
cord-354050-kcn67stj	120	26	maturation	maturation	NN
cord-354050-kcn67stj	120	27	and	and	CC
cord-354050-kcn67stj	120	28	decreases	decrease	NNS
cord-354050-kcn67stj	120	29	in	in	IN
cord-354050-kcn67stj	120	30	virion	virion	NN
cord-354050-kcn67stj	120	31	-	-	HYPH
cord-354050-kcn67stj	120	32	associated	associate	VBN
cord-354050-kcn67stj	120	33	gp120	gp120	NNP
cord-354050-kcn67stj	120	34	,	,	,
cord-354050-kcn67stj	120	35	the	the	DT
cord-354050-kcn67stj	120	36	infectious	infectious	JJ
cord-354050-kcn67stj	120	37	form	form	NN
cord-354050-kcn67stj	120	38	of	of	IN
cord-354050-kcn67stj	120	39	Env	Env	NNP
cord-354050-kcn67stj	120	40	[	[	-LRB-
cord-354050-kcn67stj	120	41	53	53	CD
cord-354050-kcn67stj	120	42	]	]	-RRB-
cord-354050-kcn67stj	120	43	.	.	.
cord-354050-kcn67stj	121	1	The	the	DT
cord-354050-kcn67stj	121	2	authors	author	NNS
cord-354050-kcn67stj	121	3	posited	posit	VBD
cord-354050-kcn67stj	121	4	that	that	IN
cord-354050-kcn67stj	121	5	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	121	6	interferes	interfere	VBZ
cord-354050-kcn67stj	121	7	with	with	IN
cord-354050-kcn67stj	121	8	Env	Env	NNP
cord-354050-kcn67stj	121	9	via	via	IN
cord-354050-kcn67stj	121	10	a	a	DT
cord-354050-kcn67stj	121	11	proteinprotein	proteinprotein	NNP
cord-354050-kcn67stj	121	12	interaction	interaction	NN
cord-354050-kcn67stj	121	13	in	in	IN
cord-354050-kcn67stj	121	14	virus	virus	NN
cord-354050-kcn67stj	121	15	-	-	HYPH
cord-354050-kcn67stj	121	16	producing	produce	VBG
cord-354050-kcn67stj	121	17	cells	cell	NNS
cord-354050-kcn67stj	121	18	.	.	.
cord-354050-kcn67stj	122	1	Of	of	IN
cord-354050-kcn67stj	122	2	note	note	NN
cord-354050-kcn67stj	122	3	,	,	,
cord-354050-kcn67stj	122	4	this	this	DT
cord-354050-kcn67stj	122	5	relationship	relationship	NN
cord-354050-kcn67stj	122	6	between	between	IN
cord-354050-kcn67stj	122	7	antiviral	antiviral	JJ
cord-354050-kcn67stj	122	8	protein	protein	NN
cord-354050-kcn67stj	122	9	and	and	CC
cord-354050-kcn67stj	122	10	Env	Env	NNP
cord-354050-kcn67stj	122	11	appears	appear	VBZ
cord-354050-kcn67stj	122	12	to	to	TO
cord-354050-kcn67stj	122	13	hold	hold	VB
cord-354050-kcn67stj	122	14	true	true	JJ
cord-354050-kcn67stj	122	15	upon	upon	IN
cord-354050-kcn67stj	122	16	examination	examination	NN
cord-354050-kcn67stj	122	17	of	of	IN
cord-354050-kcn67stj	122	18	non	non	JJ
cord-354050-kcn67stj	122	19	-	-	JJ
cord-354050-kcn67stj	122	20	human	human	JJ
cord-354050-kcn67stj	122	21	primate	primate	NN
cord-354050-kcn67stj	122	22	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	122	23	and	and	CC
cord-354050-kcn67stj	122	24	their	-PRON-	PRP$
cord-354050-kcn67stj	122	25	lentiviral	lentiviral	JJ
cord-354050-kcn67stj	122	26	counterparts	counterpart	NNS
cord-354050-kcn67stj	122	27	[	[	-LRB-
cord-354050-kcn67stj	122	28	54	54	CD
cord-354050-kcn67stj	122	29	]	]	-RRB-
cord-354050-kcn67stj	122	30	.	.	.
cord-354050-kcn67stj	123	1	Nonetheless	nonetheless	RB
cord-354050-kcn67stj	123	2	,	,	,
cord-354050-kcn67stj	123	3	there	there	EX
cord-354050-kcn67stj	123	4	exist	exist	VBP
cord-354050-kcn67stj	123	5	certain	certain	JJ
cord-354050-kcn67stj	123	6	discrepancies	discrepancy	NNS
cord-354050-kcn67stj	123	7	that	that	WDT
cord-354050-kcn67stj	123	8	cloud	cloud	VBP
cord-354050-kcn67stj	123	9	the	the	DT
cord-354050-kcn67stj	123	10	potential	potential	JJ
cord-354050-kcn67stj	123	11	importance	importance	NN
cord-354050-kcn67stj	123	12	of	of	IN
cord-354050-kcn67stj	123	13	this	this	DT
cord-354050-kcn67stj	123	14	observation	observation	NN
cord-354050-kcn67stj	123	15	.	.	.
cord-354050-kcn67stj	124	1	First	first	RB
cord-354050-kcn67stj	124	2	,	,	,
cord-354050-kcn67stj	124	3	IFITM	IFITM	NNP
cord-354050-kcn67stj	124	4	members	member	NNS
cord-354050-kcn67stj	124	5	inhibit	inhibit	VBP
cord-354050-kcn67stj	124	6	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	124	7	infectivity	infectivity	NN
cord-354050-kcn67stj	124	8	to	to	IN
cord-354050-kcn67stj	124	9	varying	vary	VBG
cord-354050-kcn67stj	124	10	degrees	degree	NNS
cord-354050-kcn67stj	124	11	(	(	-LRB-
cord-354050-kcn67stj	124	12	IFITM3	IFITM3	''
cord-354050-kcn67stj	124	13	>	>	XX
cord-354050-kcn67stj	125	1	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	126	1	>	>	XX
cord-354050-kcn67stj	127	1	IFITM1	IFITM1	NNP
cord-354050-kcn67stj	127	2	)	)	-RRB-
cord-354050-kcn67stj	128	1	[	[	-LRB-
cord-354050-kcn67stj	128	2	51	51	CD
cord-354050-kcn67stj	128	3	]	]	-RRB-
cord-354050-kcn67stj	129	1	yet	yet	RB
cord-354050-kcn67stj	129	2	all	all	DT
cord-354050-kcn67stj	129	3	three	three	CD
cord-354050-kcn67stj	129	4	proteins	protein	NNS
cord-354050-kcn67stj	129	5	inhibit	inhibit	VBP
cord-354050-kcn67stj	129	6	certain	certain	JJ
cord-354050-kcn67stj	129	7	Env	env	NN
cord-354050-kcn67stj	129	8	proteins	protein	NNS
cord-354050-kcn67stj	129	9	to	to	IN
cord-354050-kcn67stj	129	10	a	a	DT
cord-354050-kcn67stj	129	11	similar	similar	JJ
cord-354050-kcn67stj	129	12	extent	extent	NN
cord-354050-kcn67stj	129	13	[	[	-LRB-
cord-354050-kcn67stj	129	14	55	55	CD
cord-354050-kcn67stj	129	15	]	]	-RRB-
cord-354050-kcn67stj	129	16	.	.	.
cord-354050-kcn67stj	130	1	Second	second	RB
cord-354050-kcn67stj	130	2	,	,	,
cord-354050-kcn67stj	130	3	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	130	4	overexpression	overexpression	NN
cord-354050-kcn67stj	130	5	in	in	IN
cord-354050-kcn67stj	130	6	T	T	NNP
cord-354050-kcn67stj	130	7	cells	cell	NNS
cord-354050-kcn67stj	130	8	reduces	reduce	VBZ
cord-354050-kcn67stj	130	9	virus	virus	NN
cord-354050-kcn67stj	130	10	infectivity	infectivity	NN
cord-354050-kcn67stj	130	11	but	but	CC
cord-354050-kcn67stj	130	12	has	have	VBZ
cord-354050-kcn67stj	130	13	no	no	DT
cord-354050-kcn67stj	130	14	detectable	detectable	JJ
cord-354050-kcn67stj	130	15	impact	impact	NN
cord-354050-kcn67stj	130	16	on	on	IN
cord-354050-kcn67stj	130	17	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	130	18	Env	Env	NNP
cord-354050-kcn67stj	130	19	levels	level	NNS
cord-354050-kcn67stj	130	20	in	in	IN
cord-354050-kcn67stj	130	21	infected	infected	JJ
cord-354050-kcn67stj	130	22	cells	cell	NNS
cord-354050-kcn67stj	130	23	or	or	CC
cord-354050-kcn67stj	130	24	purified	purify	VBN
cord-354050-kcn67stj	130	25	virions	virion	NNS
cord-354050-kcn67stj	130	26	[	[	-LRB-
cord-354050-kcn67stj	130	27	51	51	CD
cord-354050-kcn67stj	130	28	]	]	-RRB-
cord-354050-kcn67stj	130	29	,	,	,
cord-354050-kcn67stj	130	30	and	and	CC
cord-354050-kcn67stj	130	31	a	a	DT
cord-354050-kcn67stj	130	32	lack	lack	NN
cord-354050-kcn67stj	130	33	of	of	IN
cord-354050-kcn67stj	130	34	effect	effect	NN
cord-354050-kcn67stj	130	35	has	have	VBZ
cord-354050-kcn67stj	130	36	been	be	VBN
cord-354050-kcn67stj	130	37	reported	report	VBN
cord-354050-kcn67stj	130	38	by	by	IN
cord-354050-kcn67stj	130	39	others	other	NNS
cord-354050-kcn67stj	130	40	using	use	VBG
cord-354050-kcn67stj	130	41	diverse	diverse	JJ
cord-354050-kcn67stj	130	42	experimental	experimental	JJ
cord-354050-kcn67stj	130	43	systems	system	NNS
cord-354050-kcn67stj	130	44	[	[	-LRB-
cord-354050-kcn67stj	130	45	5	5	CD
cord-354050-kcn67stj	130	46	,	,	,
cord-354050-kcn67stj	130	47	48	48	CD
cord-354050-kcn67stj	130	48	,	,	,
cord-354050-kcn67stj	130	49	56	56	CD
cord-354050-kcn67stj	130	50	]	]	-RRB-
cord-354050-kcn67stj	130	51	.	.	.
cord-354050-kcn67stj	131	1	Third	third	RB
cord-354050-kcn67stj	131	2	,	,	,
cord-354050-kcn67stj	131	3	we	-PRON-	PRP
cord-354050-kcn67stj	131	4	now	now	RB
cord-354050-kcn67stj	131	5	know	know	VBP
cord-354050-kcn67stj	131	6	that	that	IN
cord-354050-kcn67stj	131	7	the	the	DT
cord-354050-kcn67stj	131	8	negative	negative	JJ
cord-354050-kcn67stj	131	9	"	"	``
cord-354050-kcn67stj	131	10	imprinting	imprinting	NN
cord-354050-kcn67stj	131	11	"	"	''
cord-354050-kcn67stj	131	12	of	of	IN
cord-354050-kcn67stj	131	13	virions	virion	NNS
cord-354050-kcn67stj	131	14	by	by	IN
cord-354050-kcn67stj	131	15	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	131	16	occurs	occur	NNS
cord-354050-kcn67stj	131	17	with	with	IN
cord-354050-kcn67stj	131	18	various	various	JJ
cord-354050-kcn67stj	131	19	DNA	DNA	NNP
cord-354050-kcn67stj	131	20	and	and	CC
cord-354050-kcn67stj	131	21	RNA	RNA	NNP
cord-354050-kcn67stj	131	22	viruses	virus	NNS
cord-354050-kcn67stj	131	23	,	,	,
cord-354050-kcn67stj	131	24	apparently	apparently	RB
cord-354050-kcn67stj	131	25	in	in	IN
cord-354050-kcn67stj	131	26	the	the	DT
cord-354050-kcn67stj	131	27	absence	absence	NN
cord-354050-kcn67stj	131	28	of	of	IN
cord-354050-kcn67stj	131	29	envelope	envelope	NN
cord-354050-kcn67stj	131	30	glycoprotein	glycoprotein	NN
cord-354050-kcn67stj	131	31	perturbation	perturbation	NN
cord-354050-kcn67stj	131	32	[	[	-LRB-
cord-354050-kcn67stj	131	33	56	56	CD
cord-354050-kcn67stj	131	34	]	]	-RRB-
cord-354050-kcn67stj	131	35	.	.	.
cord-354050-kcn67stj	132	1	Therefore	therefore	RB
cord-354050-kcn67stj	132	2	,	,	,
cord-354050-kcn67stj	132	3	follow	follow	VB
cord-354050-kcn67stj	132	4	-	-	HYPH
cord-354050-kcn67stj	132	5	up	up	RP
cord-354050-kcn67stj	132	6	experiments	experiment	NNS
cord-354050-kcn67stj	132	7	will	will	MD
cord-354050-kcn67stj	132	8	require	require	VB
cord-354050-kcn67stj	132	9	the	the	DT
cord-354050-kcn67stj	132	10	study	study	NN
cord-354050-kcn67stj	132	11	of	of	IN
cord-354050-kcn67stj	132	12	endogenous	endogenous	JJ
cord-354050-kcn67stj	132	13	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	132	14	in	in	IN
cord-354050-kcn67stj	132	15	various	various	JJ
cord-354050-kcn67stj	132	16	cell	cell	NN
cord-354050-kcn67stj	132	17	types	type	NNS
cord-354050-kcn67stj	132	18	as	as	RB
cord-354050-kcn67stj	132	19	well	well	RB
cord-354050-kcn67stj	132	20	as	as	IN
cord-354050-kcn67stj	132	21	the	the	DT
cord-354050-kcn67stj	132	22	effects	effect	NNS
cord-354050-kcn67stj	132	23	of	of	IN
cord-354050-kcn67stj	132	24	type	type	NN
cord-354050-kcn67stj	132	25	-	-	:
cord-354050-kcn67stj	132	26	I	-PRON-	PRP
cord-354050-kcn67stj	132	27	interferon	interferon	NN
cord-354050-kcn67stj	132	28	on	on	IN
cord-354050-kcn67stj	132	29	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	132	30	Env	Env	NNP
cord-354050-kcn67stj	132	31	maturation	maturation	NN
cord-354050-kcn67stj	132	32	and	and	CC
cord-354050-kcn67stj	132	33	virion	virion	NN
cord-354050-kcn67stj	132	34	incorporation	incorporation	NN
cord-354050-kcn67stj	132	35	.	.	.
cord-354050-kcn67stj	133	1	Overall	overall	RB
cord-354050-kcn67stj	133	2	,	,	,
cord-354050-kcn67stj	133	3	it	-PRON-	PRP
cord-354050-kcn67stj	133	4	is	be	VBZ
cord-354050-kcn67stj	133	5	unclear	unclear	JJ
cord-354050-kcn67stj	133	6	whether	whether	IN
cord-354050-kcn67stj	133	7	modification	modification	NN
cord-354050-kcn67stj	133	8	of	of	IN
cord-354050-kcn67stj	133	9	Env	Env	NNP
cord-354050-kcn67stj	133	10	is	be	VBZ
cord-354050-kcn67stj	133	11	directly	directly	RB
cord-354050-kcn67stj	133	12	responsible	responsible	JJ
cord-354050-kcn67stj	133	13	for	for	IN
cord-354050-kcn67stj	133	14	the	the	DT
cord-354050-kcn67stj	133	15	inhibition	inhibition	NN
cord-354050-kcn67stj	133	16	of	of	IN
cord-354050-kcn67stj	133	17	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	133	18	virion	virion	NN
cord-354050-kcn67stj	133	19	infectivity	infectivity	NN
cord-354050-kcn67stj	133	20	,	,	,
cord-354050-kcn67stj	133	21	nor	nor	CC
cord-354050-kcn67stj	134	1	is	be	VBZ
cord-354050-kcn67stj	134	2	it	-PRON-	PRP
cord-354050-kcn67stj	134	3	known	know	VBN
cord-354050-kcn67stj	134	4	whether	whether	IN
cord-354050-kcn67stj	134	5	the	the	DT
cord-354050-kcn67stj	134	6	virion	virion	NN
cord-354050-kcn67stj	134	7	incorporation	incorporation	NN
cord-354050-kcn67stj	134	8	of	of	IN
cord-354050-kcn67stj	134	9	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	134	10	is	be	VBZ
cord-354050-kcn67stj	134	11	critical	critical	JJ
cord-354050-kcn67stj	134	12	for	for	IN
cord-354050-kcn67stj	134	13	this	this	DT
cord-354050-kcn67stj	134	14	effect	effect	NN
cord-354050-kcn67stj	134	15	.	.	.
cord-354050-kcn67stj	135	1	It	-PRON-	PRP
cord-354050-kcn67stj	135	2	is	be	VBZ
cord-354050-kcn67stj	135	3	possible	possible	JJ
cord-354050-kcn67stj	135	4	that	that	IN
cord-354050-kcn67stj	135	5	both	both	DT
cord-354050-kcn67stj	135	6	play	play	VB
cord-354050-kcn67stj	135	7	mechanistic	mechanistic	JJ
cord-354050-kcn67stj	135	8	roles	role	NNS
cord-354050-kcn67stj	135	9	which	which	WDT
cord-354050-kcn67stj	135	10	are	be	VBP
cord-354050-kcn67stj	135	11	not	not	RB
cord-354050-kcn67stj	135	12	mutually	mutually	RB
cord-354050-kcn67stj	135	13	exclusive	exclusive	JJ
cord-354050-kcn67stj	135	14	.	.	.
cord-354050-kcn67stj	136	1	Of	of	IN
cord-354050-kcn67stj	136	2	note	note	VB
cord-354050-kcn67stj	136	3	,	,	,
cord-354050-kcn67stj	136	4	enriched	enriched	JJ
cord-354050-kcn67stj	136	5	plasma	plasma	NN
cord-354050-kcn67stj	136	6	membrane	membrane	NN
cord-354050-kcn67stj	136	7	localization	localization	NN
cord-354050-kcn67stj	136	8	of	of	IN
cord-354050-kcn67stj	136	9	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	136	10	enhances	enhance	VBZ
cord-354050-kcn67stj	136	11	both	both	CC
cord-354050-kcn67stj	136	12	anti	anti	JJ
cord-354050-kcn67stj	136	13	-	-	JJ
cord-354050-kcn67stj	136	14	HIV-1	hiv-1	JJ
cord-354050-kcn67stj	136	15	activity	activity	NN
cord-354050-kcn67stj	136	16	as	as	RB
cord-354050-kcn67stj	136	17	well	well	RB
cord-354050-kcn67stj	136	18	as	as	IN
cord-354050-kcn67stj	136	19	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	136	20	incorporation	incorporation	NN
cord-354050-kcn67stj	136	21	into	into	IN
cord-354050-kcn67stj	136	22	virions	virion	NNS
cord-354050-kcn67stj	136	23	,	,	,
cord-354050-kcn67stj	136	24	suggesting	suggest	VBG
cord-354050-kcn67stj	136	25	a	a	DT
cord-354050-kcn67stj	136	26	functional	functional	JJ
cord-354050-kcn67stj	136	27	link	link	NN
cord-354050-kcn67stj	136	28	[	[	-LRB-
cord-354050-kcn67stj	136	29	5	5	CD
cord-354050-kcn67stj	136	30	]	]	-RRB-
cord-354050-kcn67stj	136	31	.	.	.
cord-354050-kcn67stj	137	1	Nonetheless	nonetheless	RB
cord-354050-kcn67stj	137	2	,	,	,
cord-354050-kcn67stj	137	3	the	the	DT
cord-354050-kcn67stj	137	4	recent	recent	JJ
cord-354050-kcn67stj	137	5	identification	identification	NN
cord-354050-kcn67stj	137	6	of	of	IN
cord-354050-kcn67stj	137	7	Env	Env	NNP
cord-354050-kcn67stj	137	8	variants	variant	NNS
cord-354050-kcn67stj	137	9	that	that	WDT
cord-354050-kcn67stj	137	10	are	be	VBP
cord-354050-kcn67stj	137	11	resistant	resistant	JJ
cord-354050-kcn67stj	137	12	to	to	IN
cord-354050-kcn67stj	137	13	the	the	DT
cord-354050-kcn67stj	137	14	IFITM3-mediated	IFITM3-mediated	NNP
cord-354050-kcn67stj	137	15	restriction	restriction	NN
cord-354050-kcn67stj	137	16	of	of	IN
cord-354050-kcn67stj	137	17	virion	virion	NN
cord-354050-kcn67stj	137	18	infectivity	infectivity	NN
cord-354050-kcn67stj	137	19	confirms	confirm	VBZ
cord-354050-kcn67stj	137	20	this	this	DT
cord-354050-kcn67stj	137	21	viral	viral	JJ
cord-354050-kcn67stj	137	22	protein	protein	NN
cord-354050-kcn67stj	137	23	as	as	IN
cord-354050-kcn67stj	137	24	an	an	DT
cord-354050-kcn67stj	137	25	important	important	JJ
cord-354050-kcn67stj	137	26	determinant	determinant	NN
cord-354050-kcn67stj	137	27	.	.	.
cord-354050-kcn67stj	138	1	It	-PRON-	PRP
cord-354050-kcn67stj	138	2	was	be	VBD
cord-354050-kcn67stj	138	3	shown	show	VBN
cord-354050-kcn67stj	138	4	that	that	IN
cord-354050-kcn67stj	138	5	a	a	DT
cord-354050-kcn67stj	138	6	particular	particular	JJ
cord-354050-kcn67stj	138	7	CCR5-tropic	CCR5-tropic	NNP
cord-354050-kcn67stj	138	8	strain	strain	NN
cord-354050-kcn67stj	138	9	(	(	-LRB-
cord-354050-kcn67stj	138	10	AD8	AD8	NNP
cord-354050-kcn67stj	138	11	)	)	-RRB-
cord-354050-kcn67stj	138	12	of	of	IN
cord-354050-kcn67stj	138	13	Env	Env	NNP
cord-354050-kcn67stj	138	14	is	be	VBZ
cord-354050-kcn67stj	138	15	unaffected	unaffected	JJ
cord-354050-kcn67stj	138	16	by	by	IN
cord-354050-kcn67stj	138	17	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	138	18	overexpression	overexpression	NN
cord-354050-kcn67stj	138	19	in	in	IN
cord-354050-kcn67stj	138	20	virus	virus	NN
cord-354050-kcn67stj	138	21	-	-	HYPH
cord-354050-kcn67stj	138	22	producing	produce	VBG
cord-354050-kcn67stj	138	23	cells	cell	NNS
cord-354050-kcn67stj	138	24	,	,	,
cord-354050-kcn67stj	138	25	exhibiting	exhibit	VBG
cord-354050-kcn67stj	138	26	no	no	DT
cord-354050-kcn67stj	138	27	defects	defect	NNS
cord-354050-kcn67stj	138	28	in	in	IN
cord-354050-kcn67stj	138	29	virion	virion	NN
cord-354050-kcn67stj	138	30	infectivity	infectivity	NN
cord-354050-kcn67stj	138	31	.	.	.
cord-354050-kcn67stj	139	1	This	this	DT
cord-354050-kcn67stj	139	2	resistance	resistance	NN
cord-354050-kcn67stj	139	3	phenotype	phenotype	NN
cord-354050-kcn67stj	139	4	maps	map	NNS
cord-354050-kcn67stj	139	5	to	to	IN
cord-354050-kcn67stj	139	6	the	the	DT
cord-354050-kcn67stj	139	7	V3	V3	NNP
cord-354050-kcn67stj	139	8	loop	loop	NN
cord-354050-kcn67stj	139	9	of	of	IN
cord-354050-kcn67stj	139	10	gp120	gp120	NN
cord-354050-kcn67stj	139	11	and	and	CC
cord-354050-kcn67stj	139	12	is	be	VBZ
cord-354050-kcn67stj	139	13	transferrable	transferrable	JJ
cord-354050-kcn67stj	139	14	to	to	IN
cord-354050-kcn67stj	139	15	other	other	JJ
cord-354050-kcn67stj	139	16	Env	Env	NNP
cord-354050-kcn67stj	139	17	isolates	isolate	NNS
cord-354050-kcn67stj	139	18	[	[	-LRB-
cord-354050-kcn67stj	139	19	57	57	CD
cord-354050-kcn67stj	139	20	]	]	-RRB-
cord-354050-kcn67stj	139	21	.	.	.
cord-354050-kcn67stj	140	1	Another	another	DT
cord-354050-kcn67stj	140	2	feature	feature	NN
cord-354050-kcn67stj	140	3	of	of	IN
cord-354050-kcn67stj	140	4	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	140	5	strains	strain	NNS
cord-354050-kcn67stj	140	6	that	that	WDT
cord-354050-kcn67stj	140	7	are	be	VBP
cord-354050-kcn67stj	140	8	most	most	RBS
cord-354050-kcn67stj	140	9	sensitive	sensitive	JJ
cord-354050-kcn67stj	140	10	to	to	IN
cord-354050-kcn67stj	140	11	the	the	DT
cord-354050-kcn67stj	140	12	IFITM3-imposed	ifitm3-impose	VBN
cord-354050-kcn67stj	140	13	block	block	NN
cord-354050-kcn67stj	140	14	to	to	IN
cord-354050-kcn67stj	140	15	virus	virus	NN
cord-354050-kcn67stj	140	16	fusogenicity	fusogenicity	NN
cord-354050-kcn67stj	140	17	is	be	VBZ
cord-354050-kcn67stj	140	18	the	the	DT
cord-354050-kcn67stj	140	19	use	use	NN
cord-354050-kcn67stj	140	20	of	of	IN
cord-354050-kcn67stj	140	21	Env	Env	NNP
cord-354050-kcn67stj	140	22	proteins	protein	NNS
cord-354050-kcn67stj	140	23	with	with	IN
cord-354050-kcn67stj	140	24	high	high	JJ
cord-354050-kcn67stj	140	25	sensitivity	sensitivity	NN
cord-354050-kcn67stj	140	26	to	to	IN
cord-354050-kcn67stj	140	27	both	both	CC
cord-354050-kcn67stj	140	28	soluble	soluble	JJ
cord-354050-kcn67stj	140	29	CD4	CD4	NNP
cord-354050-kcn67stj	140	30	and	and	CC
cord-354050-kcn67stj	140	31	the	the	DT
cord-354050-kcn67stj	140	32	neutralizing	neutralize	VBG
cord-354050-kcn67stj	140	33	antibody	antibody	NN
cord-354050-kcn67stj	140	34	17b	17b	NNS
cord-354050-kcn67stj	140	35	,	,	,
cord-354050-kcn67stj	140	36	which	which	WDT
cord-354050-kcn67stj	140	37	recognizes	recognize	VBZ
cord-354050-kcn67stj	140	38	a	a	DT
cord-354050-kcn67stj	140	39	CD4-induced	cd4-induce	VBN
cord-354050-kcn67stj	140	40	epitope	epitope	NN
cord-354050-kcn67stj	140	41	.	.	.
cord-354050-kcn67stj	141	1	Therefore	therefore	RB
cord-354050-kcn67stj	141	2	,	,	,
cord-354050-kcn67stj	141	3	virus	virus	NN
cord-354050-kcn67stj	141	4	susceptibility	susceptibility	NN
cord-354050-kcn67stj	141	5	to	to	IN
cord-354050-kcn67stj	141	6	the	the	DT
cord-354050-kcn67stj	141	7	infectivity	infectivity	NN
cord-354050-kcn67stj	141	8	defect	defect	NN
cord-354050-kcn67stj	141	9	caused	cause	VBN
cord-354050-kcn67stj	141	10	by	by	IN
cord-354050-kcn67stj	141	11	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	141	12	is	be	VBZ
cord-354050-kcn67stj	141	13	linked	link	VBN
cord-354050-kcn67stj	141	14	to	to	TO
cord-354050-kcn67stj	141	15	conformational	conformational	JJ
cord-354050-kcn67stj	141	16	changes	change	NNS
cord-354050-kcn67stj	141	17	in	in	IN
cord-354050-kcn67stj	141	18	the	the	DT
cord-354050-kcn67stj	141	19	CD4-binding	cd4-binding	NN
cord-354050-kcn67stj	141	20	site	site	NN
cord-354050-kcn67stj	141	21	of	of	IN
cord-354050-kcn67stj	141	22	Env	Env	NNP
cord-354050-kcn67stj	141	23	,	,	,
cord-354050-kcn67stj	141	24	although	although	IN
cord-354050-kcn67stj	141	25	the	the	DT
cord-354050-kcn67stj	141	26	stability	stability	NN
cord-354050-kcn67stj	141	27	or	or	CC
cord-354050-kcn67stj	141	28	clustering	clustering	NN
cord-354050-kcn67stj	141	29	of	of	IN
cord-354050-kcn67stj	141	30	virion	virion	NN
cord-354050-kcn67stj	141	31	-	-	HYPH
cord-354050-kcn67stj	141	32	incorporated	incorporate	VBN
cord-354050-kcn67stj	141	33	Env	Env	NNP
cord-354050-kcn67stj	141	34	trimers	trimer	NNS
cord-354050-kcn67stj	141	35	may	may	MD
cord-354050-kcn67stj	141	36	also	also	RB
cord-354050-kcn67stj	141	37	be	be	VB
cord-354050-kcn67stj	141	38	involved	involve	VBN
cord-354050-kcn67stj	141	39	.	.	.
cord-354050-kcn67stj	142	1	Based	base	VBN
cord-354050-kcn67stj	142	2	on	on	IN
cord-354050-kcn67stj	142	3	what	what	WP
cord-354050-kcn67stj	142	4	we	-PRON-	PRP
cord-354050-kcn67stj	142	5	know	know	VBP
cord-354050-kcn67stj	142	6	about	about	IN
cord-354050-kcn67stj	142	7	the	the	DT
cord-354050-kcn67stj	142	8	changes	change	NNS
cord-354050-kcn67stj	142	9	to	to	IN
cord-354050-kcn67stj	142	10	cellular	cellular	JJ
cord-354050-kcn67stj	142	11	membrane	membrane	NN
cord-354050-kcn67stj	142	12	fluidity	fluidity	NN
cord-354050-kcn67stj	142	13	caused	cause	VBN
cord-354050-kcn67stj	142	14	by	by	IN
cord-354050-kcn67stj	142	15	IFITM	IFITM	NNP
cord-354050-kcn67stj	142	16	proteins	protein	NNS
cord-354050-kcn67stj	142	17	,	,	,
cord-354050-kcn67stj	142	18	it	-PRON-	PRP
cord-354050-kcn67stj	142	19	is	be	VBZ
cord-354050-kcn67stj	142	20	possible	possible	JJ
cord-354050-kcn67stj	142	21	that	that	IN
cord-354050-kcn67stj	142	22	similar	similar	JJ
cord-354050-kcn67stj	142	23	disturbances	disturbance	NNS
cord-354050-kcn67stj	142	24	in	in	IN
cord-354050-kcn67stj	142	25	the	the	DT
cord-354050-kcn67stj	142	26	viral	viral	JJ
cord-354050-kcn67stj	142	27	lipid	lipid	NN
cord-354050-kcn67stj	142	28	bilayer	bilayer	NN
cord-354050-kcn67stj	142	29	containing	contain	VBG
cord-354050-kcn67stj	142	30	Env	Env	NNP
cord-354050-kcn67stj	142	31	are	be	VBP
cord-354050-kcn67stj	142	32	involved	involve	VBN
cord-354050-kcn67stj	142	33	in	in	IN
cord-354050-kcn67stj	142	34	the	the	DT
cord-354050-kcn67stj	142	35	restriction	restriction	NN
cord-354050-kcn67stj	142	36	of	of	IN
cord-354050-kcn67stj	142	37	virion	virion	NN
cord-354050-kcn67stj	142	38	infectivity	infectivity	NN
cord-354050-kcn67stj	142	39	.	.	.
cord-354050-kcn67stj	143	1	Another	another	DT
cord-354050-kcn67stj	143	2	important	important	JJ
cord-354050-kcn67stj	143	3	observation	observation	NN
cord-354050-kcn67stj	143	4	made	make	VBN
cord-354050-kcn67stj	143	5	in	in	IN
cord-354050-kcn67stj	143	6	these	these	DT
cord-354050-kcn67stj	143	7	studies	study	NNS
cord-354050-kcn67stj	143	8	is	be	VBZ
cord-354050-kcn67stj	143	9	that	that	DT
cord-354050-kcn67stj	143	10	resistance	resistance	NN
cord-354050-kcn67stj	143	11	to	to	IN
cord-354050-kcn67stj	143	12	one	one	CD
cord-354050-kcn67stj	143	13	antiviral	antiviral	JJ
cord-354050-kcn67stj	143	14	function	function	NN
cord-354050-kcn67stj	143	15	of	of	IN
cord-354050-kcn67stj	143	16	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	143	17	is	be	VBZ
cord-354050-kcn67stj	143	18	associated	associate	VBN
cord-354050-kcn67stj	143	19	with	with	IN
cord-354050-kcn67stj	143	20	resistance	resistance	NN
cord-354050-kcn67stj	143	21	to	to	IN
cord-354050-kcn67stj	143	22	another	another	DT
cord-354050-kcn67stj	143	23	,	,	,
cord-354050-kcn67stj	143	24	since	since	IN
cord-354050-kcn67stj	143	25	the	the	DT
cord-354050-kcn67stj	143	26	AD8	AD8	NNP
cord-354050-kcn67stj	143	27	strain	strain	NN
cord-354050-kcn67stj	143	28	exhibits	exhibit	VBZ
cord-354050-kcn67stj	143	29	relatively	relatively	RB
cord-354050-kcn67stj	143	30	less	less	JJR
cord-354050-kcn67stj	143	31	sensitivity	sensitivity	NN
cord-354050-kcn67stj	143	32	to	to	IN
cord-354050-kcn67stj	143	33	the	the	DT
cord-354050-kcn67stj	143	34	effects	effect	NNS
cord-354050-kcn67stj	143	35	of	of	IN
cord-354050-kcn67stj	143	36	IFITM3	ifitm3	PRP
cord-354050-kcn67stj	143	37	in	in	IN
cord-354050-kcn67stj	143	38	both	both	DT
cord-354050-kcn67stj	143	39	target	target	NN
cord-354050-kcn67stj	143	40	cells	cell	NNS
cord-354050-kcn67stj	143	41	and	and	CC
cord-354050-kcn67stj	143	42	producer	producer	NN
cord-354050-kcn67stj	143	43	cells	cell	NNS
cord-354050-kcn67stj	143	44	,	,	,
cord-354050-kcn67stj	143	45	and	and	CC
cord-354050-kcn67stj	143	46	TF	TF	NNP
cord-354050-kcn67stj	143	47	strains	strain	NNS
cord-354050-kcn67stj	143	48	are	be	VBP
cord-354050-kcn67stj	143	49	completely	completely	RB
cord-354050-kcn67stj	143	50	resistant	resistant	JJ
cord-354050-kcn67stj	143	51	to	to	IN
cord-354050-kcn67stj	143	52	both	both	DT
cord-354050-kcn67stj	143	53	modes	mode	NNS
cord-354050-kcn67stj	143	54	of	of	IN
cord-354050-kcn67stj	143	55	restriction	restriction	NN
cord-354050-kcn67stj	143	56	[	[	-LRB-
cord-354050-kcn67stj	143	57	48	48	CD
cord-354050-kcn67stj	143	58	,	,	,
cord-354050-kcn67stj	143	59	56	56	CD
cord-354050-kcn67stj	143	60	]	]	-RRB-
cord-354050-kcn67stj	143	61	.	.	.
cord-354050-kcn67stj	144	1	Thus	thus	RB
cord-354050-kcn67stj	144	2	,	,	,
cord-354050-kcn67stj	144	3	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	144	4	performs	perform	VBZ
cord-354050-kcn67stj	144	5	at	at	RB
cord-354050-kcn67stj	144	6	least	least	JJS
cord-354050-kcn67stj	144	7	two	two	CD
cord-354050-kcn67stj	144	8	antiviral	antiviral	JJ
cord-354050-kcn67stj	144	9	activities	activity	NNS
cord-354050-kcn67stj	144	10	against	against	IN
cord-354050-kcn67stj	144	11	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	144	12	for	for	IN
cord-354050-kcn67stj	144	13	which	which	WDT
cord-354050-kcn67stj	144	14	there	there	EX
cord-354050-kcn67stj	144	15	may	may	MD
cord-354050-kcn67stj	144	16	be	be	VB
cord-354050-kcn67stj	144	17	mechanistic	mechanistic	JJ
cord-354050-kcn67stj	144	18	overlap	overlap	NN
cord-354050-kcn67stj	144	19	.	.	.
cord-354050-kcn67stj	145	1	For	for	IN
cord-354050-kcn67stj	145	2	reasons	reason	NNS
cord-354050-kcn67stj	145	3	that	that	WDT
cord-354050-kcn67stj	145	4	are	be	VBP
cord-354050-kcn67stj	145	5	not	not	RB
cord-354050-kcn67stj	145	6	yet	yet	RB
cord-354050-kcn67stj	145	7	clear	clear	JJ
cord-354050-kcn67stj	145	8	,	,	,
cord-354050-kcn67stj	145	9	CD4	CD4	NNP
cord-354050-kcn67stj	145	10	engagement	engagement	NN
cord-354050-kcn67stj	145	11	by	by	IN
cord-354050-kcn67stj	145	12	Env	Env	NNP
cord-354050-kcn67stj	145	13	is	be	VBZ
cord-354050-kcn67stj	145	14	an	an	DT
cord-354050-kcn67stj	145	15	important	important	JJ
cord-354050-kcn67stj	145	16	determinant	determinant	NN
cord-354050-kcn67stj	145	17	for	for	IN
cord-354050-kcn67stj	145	18	whether	whether	IN
cord-354050-kcn67stj	145	19	virus	virus	NN
cord-354050-kcn67stj	145	20	is	be	VBZ
cord-354050-kcn67stj	145	21	restricted	restrict	VBN
cord-354050-kcn67stj	145	22	at	at	IN
cord-354050-kcn67stj	145	23	the	the	DT
cord-354050-kcn67stj	145	24	level	level	NN
cord-354050-kcn67stj	145	25	of	of	IN
cord-354050-kcn67stj	145	26	target	target	NN
cord-354050-kcn67stj	145	27	cells	cell	NNS
cord-354050-kcn67stj	145	28	and	and	CC
cord-354050-kcn67stj	145	29	producer	producer	NN
cord-354050-kcn67stj	145	30	cells	cell	NNS
cord-354050-kcn67stj	145	31	[	[	-LRB-
cord-354050-kcn67stj	145	32	48	48	CD
cord-354050-kcn67stj	145	33	,	,	,
cord-354050-kcn67stj	145	34	55	55	CD
cord-354050-kcn67stj	145	35	]	]	-RRB-
cord-354050-kcn67stj	145	36	.	.	.
cord-354050-kcn67stj	146	1	It	-PRON-	PRP
cord-354050-kcn67stj	146	2	is	be	VBZ
cord-354050-kcn67stj	146	3	possible	possible	JJ
cord-354050-kcn67stj	146	4	that	that	IN
cord-354050-kcn67stj	146	5	CD4	CD4	NNP
cord-354050-kcn67stj	146	6	binding	bind	VBG
cord-354050-kcn67stj	146	7	and	and	CC
cord-354050-kcn67stj	146	8	the	the	DT
cord-354050-kcn67stj	146	9	conformational	conformational	JJ
cord-354050-kcn67stj	146	10	changes	change	NNS
cord-354050-kcn67stj	146	11	in	in	IN
cord-354050-kcn67stj	146	12	Env	Env	NNP
cord-354050-kcn67stj	146	13	that	that	WDT
cord-354050-kcn67stj	146	14	follow	follow	NN
cord-354050-kcn67stj	146	15	(	(	-LRB-
cord-354050-kcn67stj	146	16	which	which	WDT
cord-354050-kcn67stj	146	17	dictate	dictate	VBP
cord-354050-kcn67stj	146	18	interactions	interaction	NNS
cord-354050-kcn67stj	146	19	with	with	IN
cord-354050-kcn67stj	146	20	co	co	NNS
cord-354050-kcn67stj	146	21	-	-	NNS
cord-354050-kcn67stj	146	22	receptors	receptor	NNS
cord-354050-kcn67stj	146	23	)	)	-RRB-
cord-354050-kcn67stj	146	24	affect	affect	VBP
cord-354050-kcn67stj	146	25	the	the	DT
cord-354050-kcn67stj	146	26	route	route	NN
cord-354050-kcn67stj	146	27	and	and	CC
cord-354050-kcn67stj	146	28	kinetics	kinetic	NNS
cord-354050-kcn67stj	146	29	of	of	IN
cord-354050-kcn67stj	146	30	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	146	31	entry	entry	NN
cord-354050-kcn67stj	146	32	into	into	IN
cord-354050-kcn67stj	146	33	cells	cell	NNS
cord-354050-kcn67stj	146	34	[	[	-LRB-
cord-354050-kcn67stj	146	35	58	58	CD
cord-354050-kcn67stj	146	36	]	]	-RRB-
cord-354050-kcn67stj	146	37	,	,	,
cord-354050-kcn67stj	146	38	and	and	CC
cord-354050-kcn67stj	146	39	in	in	IN
cord-354050-kcn67stj	146	40	turn	turn	NN
cord-354050-kcn67stj	146	41	,	,	,
cord-354050-kcn67stj	146	42	affect	affect	VBP
cord-354050-kcn67stj	146	43	sensitivity	sensitivity	NN
cord-354050-kcn67stj	146	44	to	to	IN
cord-354050-kcn67stj	146	45	IFITM	ifitm	NN
cord-354050-kcn67stj	146	46	-	-	HYPH
cord-354050-kcn67stj	146	47	mediated	mediate	VBN
cord-354050-kcn67stj	146	48	antiviral	antiviral	JJ
cord-354050-kcn67stj	146	49	activities	activity	NNS
cord-354050-kcn67stj	146	50	.	.	.
cord-354050-kcn67stj	147	1	Globally	globally	RB
cord-354050-kcn67stj	147	2	,	,	,
cord-354050-kcn67stj	147	3	the	the	DT
cord-354050-kcn67stj	147	4	multiple	multiple	JJ
cord-354050-kcn67stj	147	5	constraints	constraint	NNS
cord-354050-kcn67stj	147	6	that	that	WDT
cord-354050-kcn67stj	147	7	IFITM	IFITM	NNP
cord-354050-kcn67stj	147	8	proteins	protein	NNS
cord-354050-kcn67stj	147	9	place	place	VBP
cord-354050-kcn67stj	147	10	on	on	IN
cord-354050-kcn67stj	147	11	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	147	12	Env	Env	NNP
cord-354050-kcn67stj	147	13	suggest	suggest	VBP
cord-354050-kcn67stj	147	14	that	that	IN
cord-354050-kcn67stj	147	15	these	these	DT
cord-354050-kcn67stj	147	16	cellular	cellular	JJ
cord-354050-kcn67stj	147	17	factors	factor	NNS
cord-354050-kcn67stj	147	18	contribute	contribute	VBP
cord-354050-kcn67stj	147	19	to	to	IN
cord-354050-kcn67stj	147	20	the	the	DT
cord-354050-kcn67stj	147	21	genetic	genetic	JJ
cord-354050-kcn67stj	147	22	bottleneck	bottleneck	NN
cord-354050-kcn67stj	147	23	that	that	WDT
cord-354050-kcn67stj	147	24	selects	select	VBZ
cord-354050-kcn67stj	147	25	for	for	IN
cord-354050-kcn67stj	147	26	interferon	interferon	NN
cord-354050-kcn67stj	147	27	-	-	HYPH
cord-354050-kcn67stj	147	28	resistant	resistant	JJ
cord-354050-kcn67stj	147	29	virus	virus	NN
cord-354050-kcn67stj	147	30	at	at	IN
cord-354050-kcn67stj	147	31	the	the	DT
cord-354050-kcn67stj	147	32	earliest	early	JJS
cord-354050-kcn67stj	147	33	stages	stage	NNS
cord-354050-kcn67stj	147	34	of	of	IN
cord-354050-kcn67stj	147	35	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	147	36	infection	infection	NN
cord-354050-kcn67stj	147	37	in	in	IN
cord-354050-kcn67stj	147	38	vivo	vivo	NNP
cord-354050-kcn67stj	147	39	[	[	-LRB-
cord-354050-kcn67stj	147	40	59	59	CD
cord-354050-kcn67stj	147	41	]	]	-RRB-
cord-354050-kcn67stj	147	42	.	.	.
cord-354050-kcn67stj	148	1	The	the	DT
cord-354050-kcn67stj	148	2	study	study	NN
cord-354050-kcn67stj	148	3	of	of	IN
cord-354050-kcn67stj	148	4	diverse	diverse	JJ
cord-354050-kcn67stj	148	5	viruses	virus	NNS
cord-354050-kcn67stj	148	6	has	have	VBZ
cord-354050-kcn67stj	148	7	been	be	VBN
cord-354050-kcn67stj	148	8	central	central	JJ
cord-354050-kcn67stj	148	9	to	to	IN
cord-354050-kcn67stj	148	10	discoveries	discovery	NNS
cord-354050-kcn67stj	148	11	involving	involve	VBG
cord-354050-kcn67stj	148	12	the	the	DT
cord-354050-kcn67stj	148	13	IFITM	IFITM	NNP
cord-354050-kcn67stj	148	14	protein	protein	NN
cord-354050-kcn67stj	148	15	family	family	NN
cord-354050-kcn67stj	148	16	.	.	.
cord-354050-kcn67stj	149	1	The	the	DT
cord-354050-kcn67stj	149	2	physiological	physiological	JJ
cord-354050-kcn67stj	149	3	importance	importance	NN
cord-354050-kcn67stj	149	4	of	of	IN
cord-354050-kcn67stj	149	5	IFITM	IFITM	NNP
cord-354050-kcn67stj	149	6	activity	activity	NN
cord-354050-kcn67stj	149	7	has	have	VBZ
cord-354050-kcn67stj	149	8	been	be	VBN
cord-354050-kcn67stj	149	9	clearly	clearly	RB
cord-354050-kcn67stj	149	10	demonstrated	demonstrate	VBN
cord-354050-kcn67stj	149	11	for	for	IN
cord-354050-kcn67stj	149	12	those	those	DT
cord-354050-kcn67stj	149	13	viruses	virus	NNS
cord-354050-kcn67stj	149	14	that	that	WDT
cord-354050-kcn67stj	149	15	exhibit	exhibit	VBP
cord-354050-kcn67stj	149	16	the	the	DT
cord-354050-kcn67stj	149	17	greatest	great	JJS
cord-354050-kcn67stj	149	18	sensitivity	sensitivity	NN
cord-354050-kcn67stj	149	19	in	in	IN
cord-354050-kcn67stj	149	20	cell	cell	NN
cord-354050-kcn67stj	149	21	culture	culture	NN
cord-354050-kcn67stj	149	22	experiments	experiment	NNS
cord-354050-kcn67stj	149	23	,	,	,
cord-354050-kcn67stj	149	24	such	such	JJ
cord-354050-kcn67stj	149	25	as	as	IN
cord-354050-kcn67stj	149	26	IAV	IAV	NNP
cord-354050-kcn67stj	149	27	.	.	.
cord-354050-kcn67stj	150	1	However	however	RB
cord-354050-kcn67stj	150	2	,	,	,
cord-354050-kcn67stj	150	3	additional	additional	JJ
cord-354050-kcn67stj	150	4	functions	function	NNS
cord-354050-kcn67stj	150	5	were	be	VBD
cord-354050-kcn67stj	150	6	found	find	VBN
cord-354050-kcn67stj	150	7	using	use	VBG
cord-354050-kcn67stj	150	8	viruses	virus	NNS
cord-354050-kcn67stj	150	9	that	that	WDT
cord-354050-kcn67stj	150	10	are	be	VBP
cord-354050-kcn67stj	150	11	actually	actually	RB
cord-354050-kcn67stj	150	12	resistant	resistant	JJ
cord-354050-kcn67stj	150	13	to	to	IN
cord-354050-kcn67stj	150	14	the	the	DT
cord-354050-kcn67stj	150	15	block	block	NN
cord-354050-kcn67stj	150	16	at	at	IN
cord-354050-kcn67stj	150	17	cellular	cellular	JJ
cord-354050-kcn67stj	150	18	entry	entry	NN
cord-354050-kcn67stj	150	19	.	.	.
cord-354050-kcn67stj	151	1	In	in	IN
cord-354050-kcn67stj	151	2	both	both	DT
cord-354050-kcn67stj	151	3	cases	case	NNS
cord-354050-kcn67stj	151	4	,	,	,
cord-354050-kcn67stj	151	5	the	the	DT
cord-354050-kcn67stj	151	6	use	use	NN
cord-354050-kcn67stj	151	7	of	of	IN
cord-354050-kcn67stj	151	8	transgenic	transgenic	JJ
cord-354050-kcn67stj	151	9	mice	mouse	NNS
cord-354050-kcn67stj	151	10	deficient	deficient	JJ
cord-354050-kcn67stj	151	11	for	for	IN
cord-354050-kcn67stj	151	12	the	the	DT
cord-354050-kcn67stj	151	13	murine	murine	JJ
cord-354050-kcn67stj	151	14	ifitm	ifitm	NN
cord-354050-kcn67stj	151	15	locus	locus	NN
cord-354050-kcn67stj	151	16	was	be	VBD
cord-354050-kcn67stj	151	17	central	central	JJ
cord-354050-kcn67stj	151	18	to	to	IN
cord-354050-kcn67stj	151	19	establishing	establish	VBG
cord-354050-kcn67stj	151	20	the	the	DT
cord-354050-kcn67stj	151	21	in	in	IN
cord-354050-kcn67stj	151	22	vivo	vivo	NN
cord-354050-kcn67stj	151	23	significance	significance	NN
cord-354050-kcn67stj	151	24	of	of	IN
cord-354050-kcn67stj	151	25	IFITM	IFITM	NNP
cord-354050-kcn67stj	151	26	proteins	protein	NNS
cord-354050-kcn67stj	151	27	in	in	IN
cord-354050-kcn67stj	151	28	diseased	diseased	JJ
cord-354050-kcn67stj	151	29	and	and	CC
cord-354050-kcn67stj	151	30	healthy	healthy	JJ
cord-354050-kcn67stj	151	31	states	state	NNS
cord-354050-kcn67stj	151	32	.	.	.
cord-354050-kcn67stj	152	1	Downregulation	Downregulation	NNP
cord-354050-kcn67stj	152	2	of	of	IN
cord-354050-kcn67stj	152	3	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	152	4	in	in	IN
cord-354050-kcn67stj	152	5	target	target	NN
cord-354050-kcn67stj	152	6	cells	cell	NNS
cord-354050-kcn67stj	152	7	can	can	MD
cord-354050-kcn67stj	152	8	lead	lead	VB
cord-354050-kcn67stj	152	9	to	to	IN
cord-354050-kcn67stj	152	10	increased	increase	VBN
cord-354050-kcn67stj	152	11	cytopathicity	cytopathicity	NN
cord-354050-kcn67stj	152	12	upon	upon	IN
cord-354050-kcn67stj	152	13	virus	virus	NN
cord-354050-kcn67stj	152	14	challenge	challenge	NN
cord-354050-kcn67stj	152	15	in	in	IN
cord-354050-kcn67stj	152	16	vitro	vitro	FW
cord-354050-kcn67stj	152	17	,	,	,
cord-354050-kcn67stj	152	18	which	which	WDT
cord-354050-kcn67stj	152	19	has	have	VBZ
cord-354050-kcn67stj	152	20	been	be	VBN
cord-354050-kcn67stj	152	21	attributed	attribute	VBN
cord-354050-kcn67stj	152	22	to	to	IN
cord-354050-kcn67stj	152	23	its	-PRON-	PRP$
cord-354050-kcn67stj	152	24	role	role	NN
cord-354050-kcn67stj	152	25	as	as	IN
cord-354050-kcn67stj	152	26	a	a	DT
cord-354050-kcn67stj	152	27	protective	protective	JJ
cord-354050-kcn67stj	152	28	barrier	barrier	NN
cord-354050-kcn67stj	152	29	preventing	prevent	VBG
cord-354050-kcn67stj	152	30	virus	virus	NN
cord-354050-kcn67stj	152	31	entry	entry	NN
cord-354050-kcn67stj	152	32	and	and	CC
cord-354050-kcn67stj	152	33	subsequent	subsequent	JJ
cord-354050-kcn67stj	152	34	replication	replication	NN
cord-354050-kcn67stj	152	35	[	[	-LRB-
cord-354050-kcn67stj	152	36	60	60	CD
cord-354050-kcn67stj	152	37	,	,	,
cord-354050-kcn67stj	152	38	61	61	CD
cord-354050-kcn67stj	152	39	]	]	-RRB-
cord-354050-kcn67stj	152	40	.	.	.
cord-354050-kcn67stj	153	1	Nonetheless	nonetheless	RB
cord-354050-kcn67stj	153	2	,	,	,
cord-354050-kcn67stj	153	3	in	in	IN
cord-354050-kcn67stj	153	4	vivo	vivo	NN
cord-354050-kcn67stj	153	5	experiments	experiment	NNS
cord-354050-kcn67stj	153	6	using	use	VBG
cord-354050-kcn67stj	153	7	mouseadapted	mouseadapted	JJ
cord-354050-kcn67stj	153	8	virus	virus	NN
cord-354050-kcn67stj	153	9	strains	strain	NNS
cord-354050-kcn67stj	153	10	have	have	VBP
cord-354050-kcn67stj	153	11	been	be	VBN
cord-354050-kcn67stj	153	12	critically	critically	RB
cord-354050-kcn67stj	153	13	important	important	JJ
cord-354050-kcn67stj	153	14	to	to	IN
cord-354050-kcn67stj	153	15	understanding	understand	VBG
cord-354050-kcn67stj	153	16	the	the	DT
cord-354050-kcn67stj	153	17	full	full	JJ
cord-354050-kcn67stj	153	18	spectrum	spectrum	NN
cord-354050-kcn67stj	153	19	of	of	IN
cord-354050-kcn67stj	153	20	downstream	downstream	JJ
cord-354050-kcn67stj	153	21	consequences	consequence	NNS
cord-354050-kcn67stj	153	22	resulting	result	VBG
cord-354050-kcn67stj	153	23	from	from	IN
cord-354050-kcn67stj	153	24	ifitm	ifitm	NN
cord-354050-kcn67stj	153	25	deletion	deletion	NN
cord-354050-kcn67stj	153	26	,	,	,
cord-354050-kcn67stj	153	27	ranging	range	VBG
cord-354050-kcn67stj	153	28	from	from	IN
cord-354050-kcn67stj	153	29	cell	cell	NN
cord-354050-kcn67stj	153	30	death	death	NN
cord-354050-kcn67stj	153	31	to	to	IN
cord-354050-kcn67stj	153	32	the	the	DT
cord-354050-kcn67stj	153	33	manifestation	manifestation	NN
cord-354050-kcn67stj	153	34	of	of	IN
cord-354050-kcn67stj	153	35	virus	virus	NN
cord-354050-kcn67stj	153	36	-	-	HYPH
cord-354050-kcn67stj	153	37	associated	associate	VBN
cord-354050-kcn67stj	153	38	disease	disease	NN
cord-354050-kcn67stj	153	39	propagated	propagate	VBD
cord-354050-kcn67stj	153	40	throughout	throughout	IN
cord-354050-kcn67stj	153	41	the	the	DT
cord-354050-kcn67stj	153	42	host	host	NN
cord-354050-kcn67stj	153	43	organism	organism	NN
cord-354050-kcn67stj	153	44	.	.	.
cord-354050-kcn67stj	154	1	For	for	IN
cord-354050-kcn67stj	154	2	example	example	NN
cord-354050-kcn67stj	154	3	,	,	,
cord-354050-kcn67stj	154	4	accelerated	accelerated	JJ
cord-354050-kcn67stj	154	5	disease	disease	NN
cord-354050-kcn67stj	154	6	progression	progression	NN
cord-354050-kcn67stj	154	7	and	and	CC
cord-354050-kcn67stj	154	8	mortality	mortality	NN
cord-354050-kcn67stj	154	9	are	be	VBP
cord-354050-kcn67stj	154	10	observed	observe	VBN
cord-354050-kcn67stj	154	11	in	in	IN
cord-354050-kcn67stj	154	12	IFITM3-deficient	IFITM3-deficient	NNP
cord-354050-kcn67stj	154	13	mice	mouse	NNS
cord-354050-kcn67stj	154	14	challenged	challenge	VBN
cord-354050-kcn67stj	154	15	with	with	IN
cord-354050-kcn67stj	154	16	IAV	IAV	NNP
cord-354050-kcn67stj	154	17	,	,	,
cord-354050-kcn67stj	154	18	suggesting	suggest	VBG
cord-354050-kcn67stj	154	19	that	that	IN
cord-354050-kcn67stj	154	20	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	154	21	confers	confer	VBZ
cord-354050-kcn67stj	154	22	a	a	DT
cord-354050-kcn67stj	154	23	survival	survival	NN
cord-354050-kcn67stj	154	24	advantage	advantage	NN
cord-354050-kcn67stj	154	25	to	to	IN
cord-354050-kcn67stj	154	26	cells	cell	NNS
cord-354050-kcn67stj	154	27	exposed	expose	VBN
cord-354050-kcn67stj	154	28	to	to	IN
cord-354050-kcn67stj	154	29	virus	virus	NN
cord-354050-kcn67stj	154	30	[	[	-LRB-
cord-354050-kcn67stj	154	31	62	62	CD
cord-354050-kcn67stj	154	32	,	,	,
cord-354050-kcn67stj	154	33	63	63	CD
cord-354050-kcn67stj	154	34	]	]	-RRB-
cord-354050-kcn67stj	154	35	.	.	.
cord-354050-kcn67stj	155	1	Indeed	indeed	RB
cord-354050-kcn67stj	155	2	,	,	,
cord-354050-kcn67stj	155	3	the	the	DT
cord-354050-kcn67stj	155	4	expression	expression	NN
cord-354050-kcn67stj	155	5	of	of	IN
cord-354050-kcn67stj	155	6	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	155	7	may	may	MD
cord-354050-kcn67stj	155	8	preserve	preserve	VB
cord-354050-kcn67stj	155	9	the	the	DT
cord-354050-kcn67stj	155	10	integrity	integrity	NN
cord-354050-kcn67stj	155	11	and	and	CC
cord-354050-kcn67stj	155	12	function	function	NN
cord-354050-kcn67stj	155	13	of	of	IN
cord-354050-kcn67stj	155	14	cells	cell	NNS
cord-354050-kcn67stj	155	15	that	that	WDT
cord-354050-kcn67stj	155	16	would	would	MD
cord-354050-kcn67stj	155	17	otherwise	otherwise	RB
cord-354050-kcn67stj	155	18	be	be	VB
cord-354050-kcn67stj	155	19	destroyed	destroy	VBN
cord-354050-kcn67stj	155	20	by	by	IN
cord-354050-kcn67stj	155	21	uninterrupted	uninterrupted	JJ
cord-354050-kcn67stj	155	22	viral	viral	JJ
cord-354050-kcn67stj	155	23	replication	replication	NN
cord-354050-kcn67stj	155	24	[	[	-LRB-
cord-354050-kcn67stj	155	25	64	64	CD
cord-354050-kcn67stj	155	26	]	]	-RRB-
cord-354050-kcn67stj	155	27	.	.	.
cord-354050-kcn67stj	156	1	It	-PRON-	PRP
cord-354050-kcn67stj	156	2	was	be	VBD
cord-354050-kcn67stj	156	3	reported	report	VBN
cord-354050-kcn67stj	156	4	that	that	IN
cord-354050-kcn67stj	156	5	elevated	elevated	JJ
cord-354050-kcn67stj	156	6	levels	level	NNS
cord-354050-kcn67stj	156	7	of	of	IN
cord-354050-kcn67stj	156	8	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	156	9	protein	protein	NN
cord-354050-kcn67stj	156	10	in	in	IN
cord-354050-kcn67stj	156	11	memory	memory	NN
cord-354050-kcn67stj	156	12	CD8	CD8	NNP
cord-354050-kcn67stj	156	13	+	+	CC
cord-354050-kcn67stj	156	14	T	T	NNP
cord-354050-kcn67stj	156	15	lymphocytes	lymphocyte	NNS
cord-354050-kcn67stj	156	16	,	,	,
cord-354050-kcn67stj	156	17	which	which	WDT
cord-354050-kcn67stj	156	18	kill	kill	VBP
cord-354050-kcn67stj	156	19	virus	virus	NN
cord-354050-kcn67stj	156	20	-	-	HYPH
cord-354050-kcn67stj	156	21	infected	infect	VBN
cord-354050-kcn67stj	156	22	cells	cell	NNS
cord-354050-kcn67stj	156	23	and	and	CC
cord-354050-kcn67stj	156	24	serve	serve	VBP
cord-354050-kcn67stj	156	25	as	as	IN
cord-354050-kcn67stj	156	26	important	important	JJ
cord-354050-kcn67stj	156	27	targets	target	NNS
cord-354050-kcn67stj	156	28	themselves	-PRON-	PRP
cord-354050-kcn67stj	156	29	for	for	IN
cord-354050-kcn67stj	156	30	IAV	IAV	NNP
cord-354050-kcn67stj	156	31	infection	infection	NN
cord-354050-kcn67stj	156	32	in	in	IN
cord-354050-kcn67stj	156	33	the	the	DT
cord-354050-kcn67stj	156	34	lung	lung	NN
cord-354050-kcn67stj	156	35	,	,	,
cord-354050-kcn67stj	156	36	promotes	promote	VBZ
cord-354050-kcn67stj	156	37	their	-PRON-	PRP$
cord-354050-kcn67stj	156	38	survival	survival	NN
cord-354050-kcn67stj	156	39	during	during	IN
cord-354050-kcn67stj	156	40	infection	infection	NN
cord-354050-kcn67stj	156	41	and	and	CC
cord-354050-kcn67stj	156	42	enables	enable	VBZ
cord-354050-kcn67stj	156	43	long	long	JJ
cord-354050-kcn67stj	156	44	-	-	HYPH
cord-354050-kcn67stj	156	45	term	term	NN
cord-354050-kcn67stj	156	46	defense	defense	NN
cord-354050-kcn67stj	156	47	against	against	IN
cord-354050-kcn67stj	156	48	future	future	JJ
cord-354050-kcn67stj	156	49	viral	viral	JJ
cord-354050-kcn67stj	156	50	exposures	exposure	NNS
cord-354050-kcn67stj	156	51	[	[	-LRB-
cord-354050-kcn67stj	156	52	65	65	CD
cord-354050-kcn67stj	156	53	]	]	-RRB-
cord-354050-kcn67stj	156	54	.	.	.
cord-354050-kcn67stj	157	1	In	in	IN
cord-354050-kcn67stj	157	2	a	a	DT
cord-354050-kcn67stj	157	3	murine	murine	JJ
cord-354050-kcn67stj	157	4	model	model	NN
cord-354050-kcn67stj	157	5	of	of	IN
cord-354050-kcn67stj	157	6	Chikungunya	Chikungunya	NNP
cord-354050-kcn67stj	157	7	virus	virus	NN
cord-354050-kcn67stj	157	8	(	(	-LRB-
cord-354050-kcn67stj	157	9	CHIKV	CHIKV	NNP
cord-354050-kcn67stj	157	10	)	)	-RRB-
cord-354050-kcn67stj	157	11	,	,	,
cord-354050-kcn67stj	157	12	mice	mouse	NNS
cord-354050-kcn67stj	157	13	lacking	lack	VBG
cord-354050-kcn67stj	157	14	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	157	15	sustained	sustain	VBD
cord-354050-kcn67stj	157	16	greater	great	JJR
cord-354050-kcn67stj	157	17	joint	joint	JJ
cord-354050-kcn67stj	157	18	swelling	swelling	NN
cord-354050-kcn67stj	157	19	which	which	WDT
cord-354050-kcn67stj	157	20	was	be	VBD
cord-354050-kcn67stj	157	21	correlated	correlate	VBN
cord-354050-kcn67stj	157	22	to	to	IN
cord-354050-kcn67stj	157	23	increased	increase	VBN
cord-354050-kcn67stj	157	24	viral	viral	JJ
cord-354050-kcn67stj	157	25	burden	burden	NN
cord-354050-kcn67stj	157	26	and	and	CC
cord-354050-kcn67stj	157	27	pro	pro	JJ
cord-354050-kcn67stj	157	28	-	-	JJ
cord-354050-kcn67stj	157	29	inflammatory	inflammatory	JJ
cord-354050-kcn67stj	157	30	cytokine	cytokine	NN
cord-354050-kcn67stj	157	31	production	production	NN
cord-354050-kcn67stj	157	32	[	[	-LRB-
cord-354050-kcn67stj	157	33	66	66	CD
cord-354050-kcn67stj	157	34	]	]	-RRB-
cord-354050-kcn67stj	157	35	.	.	.
cord-354050-kcn67stj	158	1	IFITM3-deficient	ifitm3-deficient	XX
cord-354050-kcn67stj	159	1	mice	mouse	NNS
cord-354050-kcn67stj	159	2	were	be	VBD
cord-354050-kcn67stj	159	3	also	also	RB
cord-354050-kcn67stj	159	4	found	find	VBN
cord-354050-kcn67stj	159	5	to	to	TO
cord-354050-kcn67stj	159	6	be	be	VB
cord-354050-kcn67stj	159	7	more	more	RBR
cord-354050-kcn67stj	159	8	vulnerable	vulnerable	JJ
cord-354050-kcn67stj	159	9	to	to	IN
cord-354050-kcn67stj	159	10	lethality	lethality	NN
cord-354050-kcn67stj	159	11	in	in	IN
cord-354050-kcn67stj	159	12	the	the	DT
cord-354050-kcn67stj	159	13	context	context	NN
cord-354050-kcn67stj	159	14	of	of	IN
cord-354050-kcn67stj	159	15	WNV	WNV	NNP
cord-354050-kcn67stj	159	16	.	.	.
cord-354050-kcn67stj	160	1	While	while	IN
cord-354050-kcn67stj	160	2	WNV	WNV	NNP
cord-354050-kcn67stj	160	3	disease	disease	NN
cord-354050-kcn67stj	160	4	is	be	VBZ
cord-354050-kcn67stj	160	5	associated	associate	VBN
cord-354050-kcn67stj	160	6	with	with	IN
cord-354050-kcn67stj	160	7	neurotropism	neurotropism	NN
cord-354050-kcn67stj	160	8	,	,	,
cord-354050-kcn67stj	160	9	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	160	10	limited	limited	JJ
cord-354050-kcn67stj	160	11	pathogenesis	pathogenesis	NN
cord-354050-kcn67stj	160	12	by	by	IN
cord-354050-kcn67stj	160	13	suppressing	suppress	VBG
cord-354050-kcn67stj	160	14	viremia	viremia	NN
cord-354050-kcn67stj	160	15	first	first	RB
cord-354050-kcn67stj	160	16	in	in	IN
cord-354050-kcn67stj	160	17	peripheral	peripheral	JJ
cord-354050-kcn67stj	160	18	organs	organ	NNS
cord-354050-kcn67stj	160	19	[	[	-LRB-
cord-354050-kcn67stj	160	20	67	67	CD
cord-354050-kcn67stj	160	21	]	]	-RRB-
cord-354050-kcn67stj	160	22	.	.	.
cord-354050-kcn67stj	161	1	Thus	thus	RB
cord-354050-kcn67stj	161	2	,	,	,
cord-354050-kcn67stj	161	3	by	by	IN
cord-354050-kcn67stj	161	4	acting	act	VBG
cord-354050-kcn67stj	161	5	as	as	IN
cord-354050-kcn67stj	161	6	the	the	DT
cord-354050-kcn67stj	161	7	first	first	JJ
cord-354050-kcn67stj	161	8	line	line	NN
cord-354050-kcn67stj	161	9	of	of	IN
cord-354050-kcn67stj	161	10	defense	defense	NN
cord-354050-kcn67stj	161	11	in	in	IN
cord-354050-kcn67stj	161	12	cells	cell	NNS
cord-354050-kcn67stj	161	13	exposed	expose	VBN
cord-354050-kcn67stj	161	14	to	to	IN
cord-354050-kcn67stj	161	15	invading	invade	VBG
cord-354050-kcn67stj	161	16	viruses	virus	NNS
cord-354050-kcn67stj	161	17	,	,	,
cord-354050-kcn67stj	161	18	IFITM	IFITM	NNP
cord-354050-kcn67stj	161	19	proteins	protein	NNS
cord-354050-kcn67stj	161	20	prevent	prevent	VBP
cord-354050-kcn67stj	161	21	a	a	DT
cord-354050-kcn67stj	161	22	plethora	plethora	NN
cord-354050-kcn67stj	161	23	of	of	IN
cord-354050-kcn67stj	161	24	adverse	adverse	JJ
cord-354050-kcn67stj	161	25	events	event	NNS
cord-354050-kcn67stj	161	26	that	that	WDT
cord-354050-kcn67stj	161	27	can	can	MD
cord-354050-kcn67stj	161	28	lead	lead	VB
cord-354050-kcn67stj	161	29	to	to	IN
cord-354050-kcn67stj	161	30	disease	disease	NN
cord-354050-kcn67stj	161	31	and	and	CC
cord-354050-kcn67stj	161	32	death	death	NN
cord-354050-kcn67stj	161	33	.	.	.
cord-354050-kcn67stj	162	1	Yet	yet	CC
cord-354050-kcn67stj	162	2	unexpected	unexpected	JJ
cord-354050-kcn67stj	162	3	antiviral	antiviral	JJ
cord-354050-kcn67stj	162	4	activities	activity	NNS
cord-354050-kcn67stj	162	5	associated	associate	VBN
cord-354050-kcn67stj	162	6	with	with	IN
cord-354050-kcn67stj	162	7	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	162	8	were	be	VBD
cord-354050-kcn67stj	162	9	revealed	reveal	VBN
cord-354050-kcn67stj	162	10	during	during	IN
cord-354050-kcn67stj	162	11	murine	murine	JJ
cord-354050-kcn67stj	162	12	cytomegalovirus	cytomegalovirus	NN
cord-354050-kcn67stj	162	13	(	(	-LRB-
cord-354050-kcn67stj	162	14	CMV	CMV	NNP
cord-354050-kcn67stj	162	15	)	)	-RRB-
cord-354050-kcn67stj	162	16	infection	infection	NN
cord-354050-kcn67stj	162	17	.	.	.
cord-354050-kcn67stj	163	1	In	in	IN
cord-354050-kcn67stj	163	2	this	this	DT
cord-354050-kcn67stj	163	3	case	case	NN
cord-354050-kcn67stj	163	4	,	,	,
cord-354050-kcn67stj	163	5	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	163	6	does	do	VBZ
cord-354050-kcn67stj	163	7	not	not	RB
cord-354050-kcn67stj	163	8	limit	limit	VB
cord-354050-kcn67stj	163	9	virus	virus	NN
cord-354050-kcn67stj	163	10	entry	entry	NN
cord-354050-kcn67stj	163	11	into	into	IN
cord-354050-kcn67stj	163	12	cells	cell	NNS
cord-354050-kcn67stj	163	13	(	(	-LRB-
cord-354050-kcn67stj	163	14	the	the	DT
cord-354050-kcn67stj	163	15	protein	protein	NN
cord-354050-kcn67stj	163	16	was	be	VBD
cord-354050-kcn67stj	163	17	previously	previously	RB
cord-354050-kcn67stj	163	18	shown	show	VBN
cord-354050-kcn67stj	163	19	to	to	TO
cord-354050-kcn67stj	163	20	facilitate	facilitate	VB
cord-354050-kcn67stj	163	21	CMV	CMV	NNP
cord-354050-kcn67stj	163	22	virion	virion	NN
cord-354050-kcn67stj	163	23	morphogenesis	morphogenesis	NN
cord-354050-kcn67stj	163	24	[	[	-LRB-
cord-354050-kcn67stj	163	25	68	68	CD
cord-354050-kcn67stj	163	26	]	]	-RRB-
cord-354050-kcn67stj	163	27	)	)	-RRB-
cord-354050-kcn67stj	163	28	.	.	.
cord-354050-kcn67stj	164	1	Rather	rather	RB
cord-354050-kcn67stj	164	2	,	,	,
cord-354050-kcn67stj	164	3	CMV	CMV	NNP
cord-354050-kcn67stj	164	4	infection	infection	NN
cord-354050-kcn67stj	164	5	in	in	IN
cord-354050-kcn67stj	164	6	IFITM3-deficient	IFITM3-deficient	NNP
cord-354050-kcn67stj	164	7	mice	mouse	NNS
cord-354050-kcn67stj	164	8	led	lead	VBD
cord-354050-kcn67stj	164	9	to	to	IN
cord-354050-kcn67stj	164	10	much	much	RB
cord-354050-kcn67stj	164	11	higher	high	JJR
cord-354050-kcn67stj	164	12	production	production	NN
cord-354050-kcn67stj	164	13	of	of	IN
cord-354050-kcn67stj	164	14	the	the	DT
cord-354050-kcn67stj	164	15	pro	pro	JJ
cord-354050-kcn67stj	164	16	-	-	JJ
cord-354050-kcn67stj	164	17	inflammatory	inflammatory	JJ
cord-354050-kcn67stj	164	18	cytokine	cytokine	NN
cord-354050-kcn67stj	164	19	interleukin-6	interleukin-6	NNP
cord-354050-kcn67stj	164	20	(	(	-LRB-
cord-354050-kcn67stj	164	21	IL-6	IL-6	NNP
cord-354050-kcn67stj	164	22	)	)	-RRB-
cord-354050-kcn67stj	164	23	[	[	-LRB-
cord-354050-kcn67stj	164	24	69	69	CD
cord-354050-kcn67stj	164	25	]	]	-RRB-
cord-354050-kcn67stj	164	26	.	.	.
cord-354050-kcn67stj	165	1	The	the	DT
cord-354050-kcn67stj	165	2	result	result	NN
cord-354050-kcn67stj	165	3	was	be	VBD
cord-354050-kcn67stj	165	4	dysregulation	dysregulation	NN
cord-354050-kcn67stj	165	5	of	of	IN
cord-354050-kcn67stj	165	6	cellular	cellular	JJ
cord-354050-kcn67stj	165	7	immunity	immunity	NN
cord-354050-kcn67stj	165	8	and	and	CC
cord-354050-kcn67stj	165	9	impaired	impaired	JJ
cord-354050-kcn67stj	165	10	control	control	NN
cord-354050-kcn67stj	165	11	of	of	IN
cord-354050-kcn67stj	165	12	virus	virus	NN
cord-354050-kcn67stj	165	13	replication	replication	NN
cord-354050-kcn67stj	165	14	,	,	,
cord-354050-kcn67stj	165	15	suggesting	suggest	VBG
cord-354050-kcn67stj	165	16	that	that	IN
cord-354050-kcn67stj	165	17	murine	murine	NN
cord-354050-kcn67stj	165	18	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	165	19	plays	play	VBZ
cord-354050-kcn67stj	165	20	a	a	DT
cord-354050-kcn67stj	165	21	part	part	NN
cord-354050-kcn67stj	165	22	in	in	IN
cord-354050-kcn67stj	165	23	regulating	regulate	VBG
cord-354050-kcn67stj	165	24	cytokine	cytokine	NN
cord-354050-kcn67stj	165	25	production	production	NN
cord-354050-kcn67stj	165	26	important	important	JJ
cord-354050-kcn67stj	165	27	for	for	IN
cord-354050-kcn67stj	165	28	resolution	resolution	NN
cord-354050-kcn67stj	165	29	of	of	IN
cord-354050-kcn67stj	165	30	virus	virus	NN
cord-354050-kcn67stj	165	31	infection	infection	NN
cord-354050-kcn67stj	165	32	.	.	.
cord-354050-kcn67stj	166	1	Another	another	DT
cord-354050-kcn67stj	166	2	example	example	NN
cord-354050-kcn67stj	166	3	in	in	IN
cord-354050-kcn67stj	166	4	which	which	WDT
cord-354050-kcn67stj	166	5	IFITM3	ifitm3	PRP
cord-354050-kcn67stj	166	6	could	could	MD
cord-354050-kcn67stj	166	7	be	be	VB
cord-354050-kcn67stj	166	8	found	find	VBN
cord-354050-kcn67stj	166	9	performing	perform	VBG
cord-354050-kcn67stj	166	10	a	a	DT
cord-354050-kcn67stj	166	11	non	non	JJ
cord-354050-kcn67stj	166	12	-	-	JJ
cord-354050-kcn67stj	166	13	canonical	canonical	JJ
cord-354050-kcn67stj	166	14	activity	activity	NN
cord-354050-kcn67stj	166	15	was	be	VBD
cord-354050-kcn67stj	166	16	in	in	IN
cord-354050-kcn67stj	166	17	the	the	DT
cord-354050-kcn67stj	166	18	setting	setting	NN
cord-354050-kcn67stj	166	19	of	of	IN
cord-354050-kcn67stj	166	20	Sendai	Sendai	NNP
cord-354050-kcn67stj	166	21	Virus	Virus	NNP
cord-354050-kcn67stj	166	22	(	(	-LRB-
cord-354050-kcn67stj	166	23	SeV	sev	NN
cord-354050-kcn67stj	166	24	)	)	-RRB-
cord-354050-kcn67stj	166	25	infection	infection	NN
cord-354050-kcn67stj	166	26	.	.	.
cord-354050-kcn67stj	167	1	This	this	DT
cord-354050-kcn67stj	167	2	murine	murine	JJ
cord-354050-kcn67stj	167	3	paramyxovirus	paramyxovirus	NN
cord-354050-kcn67stj	167	4	has	have	VBZ
cord-354050-kcn67stj	167	5	been	be	VBN
cord-354050-kcn67stj	167	6	shown	show	VBN
cord-354050-kcn67stj	167	7	to	to	TO
cord-354050-kcn67stj	167	8	be	be	VB
cord-354050-kcn67stj	167	9	insensitive	insensitive	JJ
cord-354050-kcn67stj	167	10	to	to	IN
cord-354050-kcn67stj	167	11	the	the	DT
cord-354050-kcn67stj	167	12	IFITM3-mediated	IFITM3-mediated	NNP
cord-354050-kcn67stj	167	13	block	block	NN
cord-354050-kcn67stj	167	14	to	to	IN
cord-354050-kcn67stj	167	15	virus	virus	NN
cord-354050-kcn67stj	167	16	entry	entry	NN
cord-354050-kcn67stj	167	17	[	[	-LRB-
cord-354050-kcn67stj	167	18	70	70	CD
cord-354050-kcn67stj	167	19	]	]	-RRB-
cord-354050-kcn67stj	167	20	.	.	.
cord-354050-kcn67stj	168	1	Notwithstanding	notwithstanding	IN
cord-354050-kcn67stj	168	2	,	,	,
cord-354050-kcn67stj	168	3	it	-PRON-	PRP
cord-354050-kcn67stj	168	4	was	be	VBD
cord-354050-kcn67stj	168	5	shown	show	VBN
cord-354050-kcn67stj	168	6	that	that	IN
cord-354050-kcn67stj	168	7	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	168	8	regulates	regulate	VBZ
cord-354050-kcn67stj	168	9	interferonbeta	interferonbeta	JJ
cord-354050-kcn67stj	168	10	production	production	NN
cord-354050-kcn67stj	168	11	triggered	trigger	VBN
cord-354050-kcn67stj	168	12	by	by	IN
cord-354050-kcn67stj	168	13	SeV	sev	NN
cord-354050-kcn67stj	168	14	infection	infection	NN
cord-354050-kcn67stj	168	15	in	in	IN
cord-354050-kcn67stj	168	16	human	human	JJ
cord-354050-kcn67stj	168	17	cell	cell	NN
cord-354050-kcn67stj	168	18	lines	line	NNS
cord-354050-kcn67stj	168	19	[	[	-LRB-
cord-354050-kcn67stj	168	20	71	71	CD
cord-354050-kcn67stj	168	21	]	]	-RRB-
cord-354050-kcn67stj	168	22	.	.	.
cord-354050-kcn67stj	169	1	That	that	RB
cord-354050-kcn67stj	169	2	is	is	RB
cord-354050-kcn67stj	169	3	,	,	,
cord-354050-kcn67stj	169	4	overexpression	overexpression	NN
cord-354050-kcn67stj	169	5	of	of	IN
cord-354050-kcn67stj	169	6	IFITM3	ifitm3	JJ
cord-354050-kcn67stj	169	7	inhibited	inhibited	JJ
cord-354050-kcn67stj	169	8	production	production	NN
cord-354050-kcn67stj	169	9	of	of	IN
cord-354050-kcn67stj	169	10	the	the	DT
cord-354050-kcn67stj	169	11	cytokine	cytokine	NN
cord-354050-kcn67stj	169	12	while	while	IN
cord-354050-kcn67stj	169	13	knockdown	knockdown	NN
cord-354050-kcn67stj	169	14	had	have	VBD
cord-354050-kcn67stj	169	15	the	the	DT
cord-354050-kcn67stj	169	16	opposite	opposite	JJ
cord-354050-kcn67stj	169	17	effect	effect	NN
cord-354050-kcn67stj	169	18	.	.	.
cord-354050-kcn67stj	170	1	The	the	DT
cord-354050-kcn67stj	170	2	authors	author	NNS
cord-354050-kcn67stj	170	3	propose	propose	VBP
cord-354050-kcn67stj	170	4	that	that	IN
cord-354050-kcn67stj	170	5	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	170	6	associates	associate	NNS
cord-354050-kcn67stj	170	7	with	with	IN
cord-354050-kcn67stj	170	8	the	the	DT
cord-354050-kcn67stj	170	9	transcription	transcription	NN
cord-354050-kcn67stj	170	10	factor	factor	NN
cord-354050-kcn67stj	170	11	driving	drive	VBG
cord-354050-kcn67stj	170	12	interferon	interferon	NN
cord-354050-kcn67stj	170	13	-	-	HYPH
cord-354050-kcn67stj	170	14	beta	beta	NN
cord-354050-kcn67stj	170	15	gene	gene	NN
cord-354050-kcn67stj	170	16	expression	expression	NN
cord-354050-kcn67stj	170	17	,	,	,
cord-354050-kcn67stj	170	18	IRF3	IRF3	NNP
cord-354050-kcn67stj	170	19	,	,	,
cord-354050-kcn67stj	170	20	and	and	CC
cord-354050-kcn67stj	170	21	accelerates	accelerate	VBZ
cord-354050-kcn67stj	170	22	its	-PRON-	PRP$
cord-354050-kcn67stj	170	23	turnover	turnover	NN
cord-354050-kcn67stj	170	24	in	in	IN
cord-354050-kcn67stj	170	25	autophagosomes	autophagosomes	NNP
cord-354050-kcn67stj	170	26	.	.	.
cord-354050-kcn67stj	171	1	Since	since	IN
cord-354050-kcn67stj	171	2	interferon	interferon	NN
cord-354050-kcn67stj	171	3	-	-	HYPH
cord-354050-kcn67stj	171	4	beta	beta	NN
cord-354050-kcn67stj	171	5	itself	-PRON-	PRP
cord-354050-kcn67stj	171	6	induces	induce	VBZ
cord-354050-kcn67stj	171	7	the	the	DT
cord-354050-kcn67stj	171	8	expression	expression	NN
cord-354050-kcn67stj	171	9	of	of	IN
cord-354050-kcn67stj	171	10	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	171	11	,	,	,
cord-354050-kcn67stj	171	12	this	this	DT
cord-354050-kcn67stj	171	13	implies	imply	VBZ
cord-354050-kcn67stj	171	14	a	a	DT
cord-354050-kcn67stj	171	15	role	role	NN
cord-354050-kcn67stj	171	16	in	in	IN
cord-354050-kcn67stj	171	17	negative	negative	JJ
cord-354050-kcn67stj	171	18	feedback	feedback	NN
cord-354050-kcn67stj	171	19	of	of	IN
cord-354050-kcn67stj	171	20	the	the	DT
cord-354050-kcn67stj	171	21	interferon	interferon	NN
cord-354050-kcn67stj	171	22	pathway	pathway	NN
cord-354050-kcn67stj	171	23	[	[	-LRB-
cord-354050-kcn67stj	171	24	71	71	CD
cord-354050-kcn67stj	171	25	]	]	-RRB-
cord-354050-kcn67stj	171	26	.	.	.
cord-354050-kcn67stj	172	1	This	this	DT
cord-354050-kcn67stj	172	2	finding	find	VBG
cord-354050-kcn67stj	172	3	warrants	warrant	NNS
cord-354050-kcn67stj	172	4	testing	test	VBG
cord-354050-kcn67stj	172	5	in	in	IN
cord-354050-kcn67stj	172	6	an	an	DT
cord-354050-kcn67stj	172	7	in	in	IN
cord-354050-kcn67stj	172	8	vivo	vivo	NN
cord-354050-kcn67stj	172	9	murine	murine	JJ
cord-354050-kcn67stj	172	10	model	model	NN
cord-354050-kcn67stj	172	11	,	,	,
cord-354050-kcn67stj	172	12	but	but	CC
cord-354050-kcn67stj	172	13	it	-PRON-	PRP
cord-354050-kcn67stj	172	14	seems	seem	VBZ
cord-354050-kcn67stj	172	15	likely	likely	JJ
cord-354050-kcn67stj	172	16	that	that	IN
cord-354050-kcn67stj	172	17	the	the	DT
cord-354050-kcn67stj	172	18	effects	effect	NNS
cord-354050-kcn67stj	172	19	of	of	IN
cord-354050-kcn67stj	172	20	IFITM	IFITM	NNP
cord-354050-kcn67stj	172	21	proteins	protein	NNS
cord-354050-kcn67stj	172	22	on	on	IN
cord-354050-kcn67stj	172	23	interferon	interferon	NN
cord-354050-kcn67stj	172	24	signaling	signaling	NN
cord-354050-kcn67stj	172	25	will	will	MD
cord-354050-kcn67stj	172	26	yield	yield	VB
cord-354050-kcn67stj	172	27	much	much	JJ
cord-354050-kcn67stj	172	28	interest	interest	NN
cord-354050-kcn67stj	172	29	from	from	IN
cord-354050-kcn67stj	172	30	researchers	researcher	NNS
cord-354050-kcn67stj	172	31	and	and	CC
cord-354050-kcn67stj	172	32	clinicians	clinician	NNS
cord-354050-kcn67stj	172	33	in	in	IN
cord-354050-kcn67stj	172	34	the	the	DT
cord-354050-kcn67stj	172	35	field	field	NN
cord-354050-kcn67stj	172	36	of	of	IN
cord-354050-kcn67stj	172	37	microbial	microbial	JJ
cord-354050-kcn67stj	172	38	pathogenesis	pathogenesis	NN
cord-354050-kcn67stj	172	39	.	.	.
cord-354050-kcn67stj	173	1	Naturally	naturally	RB
cord-354050-kcn67stj	173	2	occurring	occur	VBG
cord-354050-kcn67stj	173	3	variation	variation	NN
cord-354050-kcn67stj	173	4	in	in	IN
cord-354050-kcn67stj	173	5	IFITM	IFITM	NNP
cord-354050-kcn67stj	173	6	genes	gene	NNS
cord-354050-kcn67stj	173	7	has	have	VBZ
cord-354050-kcn67stj	173	8	provided	provide	VBN
cord-354050-kcn67stj	173	9	an	an	DT
cord-354050-kcn67stj	173	10	additional	additional	JJ
cord-354050-kcn67stj	173	11	genetic	genetic	JJ
cord-354050-kcn67stj	173	12	platform	platform	NN
cord-354050-kcn67stj	173	13	for	for	IN
cord-354050-kcn67stj	173	14	the	the	DT
cord-354050-kcn67stj	173	15	study	study	NN
cord-354050-kcn67stj	173	16	of	of	IN
cord-354050-kcn67stj	173	17	pathogenic	pathogenic	JJ
cord-354050-kcn67stj	173	18	virus	virus	NN
cord-354050-kcn67stj	173	19	infections	infection	NNS
cord-354050-kcn67stj	173	20	important	important	JJ
cord-354050-kcn67stj	173	21	to	to	IN
cord-354050-kcn67stj	173	22	human	human	JJ
cord-354050-kcn67stj	173	23	public	public	JJ
cord-354050-kcn67stj	173	24	health	health	NN
cord-354050-kcn67stj	173	25	.	.	.
cord-354050-kcn67stj	174	1	Population	population	NN
cord-354050-kcn67stj	174	2	-	-	HYPH
cord-354050-kcn67stj	174	3	level	level	NN
cord-354050-kcn67stj	174	4	associations	association	NNS
cord-354050-kcn67stj	174	5	have	have	VBP
cord-354050-kcn67stj	174	6	been	be	VBN
cord-354050-kcn67stj	174	7	drawn	draw	VBN
cord-354050-kcn67stj	174	8	between	between	IN
cord-354050-kcn67stj	174	9	single	single	JJ
cord-354050-kcn67stj	174	10	-	-	HYPH
cord-354050-kcn67stj	174	11	nucleotide	nucleotide	NN
cord-354050-kcn67stj	174	12	polymorphisms	polymorphism	NNS
cord-354050-kcn67stj	174	13	(	(	-LRB-
cord-354050-kcn67stj	174	14	SNP	SNP	NNP
cord-354050-kcn67stj	174	15	)	)	-RRB-
cord-354050-kcn67stj	174	16	in	in	IN
cord-354050-kcn67stj	174	17	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	174	18	and	and	CC
cord-354050-kcn67stj	174	19	severe	severe	JJ
cord-354050-kcn67stj	174	20	outcomes	outcome	NNS
cord-354050-kcn67stj	174	21	following	follow	VBG
cord-354050-kcn67stj	174	22	IAV	IAV	NNP
cord-354050-kcn67stj	174	23	infection	infection	NN
cord-354050-kcn67stj	174	24	,	,	,
cord-354050-kcn67stj	174	25	corroborating	corroborate	VBG
cord-354050-kcn67stj	174	26	an	an	DT
cord-354050-kcn67stj	174	27	important	important	JJ
cord-354050-kcn67stj	174	28	in	in	IN
cord-354050-kcn67stj	174	29	vivo	vivo	NN
cord-354050-kcn67stj	174	30	function	function	NN
cord-354050-kcn67stj	174	31	but	but	CC
cord-354050-kcn67stj	174	32	lacking	lack	VBG
cord-354050-kcn67stj	174	33	a	a	DT
cord-354050-kcn67stj	174	34	mechanistic	mechanistic	JJ
cord-354050-kcn67stj	174	35	explanation	explanation	NN
cord-354050-kcn67stj	174	36	.	.	.
cord-354050-kcn67stj	175	1	The	the	DT
cord-354050-kcn67stj	175	2	most	most	RBS
cord-354050-kcn67stj	175	3	cited	cite	VBN
cord-354050-kcn67stj	175	4	example	example	NN
cord-354050-kcn67stj	175	5	is	be	VBZ
cord-354050-kcn67stj	175	6	rs12252-C	rs12252-C	NNP
cord-354050-kcn67stj	175	7	,	,	,
cord-354050-kcn67stj	175	8	a	a	DT
cord-354050-kcn67stj	175	9	nonsynonymous	nonsynonymous	JJ
cord-354050-kcn67stj	175	10	mutation	mutation	NN
cord-354050-kcn67stj	175	11	in	in	IN
cord-354050-kcn67stj	175	12	the	the	DT
cord-354050-kcn67stj	175	13	first	first	JJ
cord-354050-kcn67stj	175	14	coding	coding	NN
cord-354050-kcn67stj	175	15	exon	exon	NN
cord-354050-kcn67stj	175	16	of	of	IN
cord-354050-kcn67stj	175	17	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	175	18	,	,	,
cord-354050-kcn67stj	175	19	which	which	WDT
cord-354050-kcn67stj	175	20	was	be	VBD
cord-354050-kcn67stj	175	21	predicted	predict	VBN
cord-354050-kcn67stj	175	22	to	to	TO
cord-354050-kcn67stj	175	23	affect	affect	VB
cord-354050-kcn67stj	175	24	mRNA	mrna	NN
cord-354050-kcn67stj	175	25	splicing	splicing	NN
cord-354050-kcn67stj	175	26	and	and	CC
cord-354050-kcn67stj	175	27	to	to	TO
cord-354050-kcn67stj	175	28	produce	produce	VB
cord-354050-kcn67stj	175	29	protein	protein	NN
cord-354050-kcn67stj	175	30	with	with	IN
cord-354050-kcn67stj	175	31	an	an	DT
cord-354050-kcn67stj	175	32	amino	amino	NN
cord-354050-kcn67stj	175	33	-	-	HYPH
cord-354050-kcn67stj	175	34	terminal	terminal	NN
cord-354050-kcn67stj	175	35	truncation	truncation	NN
cord-354050-kcn67stj	175	36	[	[	-LRB-
cord-354050-kcn67stj	175	37	63	63	CD
cord-354050-kcn67stj	175	38	]	]	-RRB-
cord-354050-kcn67stj	175	39	.	.	.
cord-354050-kcn67stj	176	1	This	this	DT
cord-354050-kcn67stj	176	2	minor	minor	JJ
cord-354050-kcn67stj	176	3	variant	variant	NN
cord-354050-kcn67stj	176	4	was	be	VBD
cord-354050-kcn67stj	176	5	found	find	VBN
cord-354050-kcn67stj	176	6	to	to	TO
cord-354050-kcn67stj	176	7	be	be	VB
cord-354050-kcn67stj	176	8	enriched	enrich	VBN
cord-354050-kcn67stj	176	9	in	in	IN
cord-354050-kcn67stj	176	10	a	a	DT
cord-354050-kcn67stj	176	11	group	group	NN
cord-354050-kcn67stj	176	12	of	of	IN
cord-354050-kcn67stj	176	13	individuals	individual	NNS
cord-354050-kcn67stj	176	14	hospitalized	hospitalize	VBN
cord-354050-kcn67stj	176	15	following	follow	VBG
cord-354050-kcn67stj	176	16	IAV	IAV	NNP
cord-354050-kcn67stj	176	17	infection	infection	NN
cord-354050-kcn67stj	176	18	,	,	,
cord-354050-kcn67stj	176	19	and	and	CC
cord-354050-kcn67stj	176	20	it	-PRON-	PRP
cord-354050-kcn67stj	176	21	is	be	VBZ
cord-354050-kcn67stj	176	22	found	find	VBN
cord-354050-kcn67stj	176	23	at	at	IN
cord-354050-kcn67stj	176	24	relatively	relatively	RB
cord-354050-kcn67stj	176	25	high	high	JJ
cord-354050-kcn67stj	176	26	frequency	frequency	NN
cord-354050-kcn67stj	176	27	among	among	IN
cord-354050-kcn67stj	176	28	Asian	asian	JJ
cord-354050-kcn67stj	176	29	ethnic	ethnic	JJ
cord-354050-kcn67stj	176	30	groups	group	NNS
cord-354050-kcn67stj	176	31	.	.	.
cord-354050-kcn67stj	177	1	However	however	RB
cord-354050-kcn67stj	177	2	,	,	,
cord-354050-kcn67stj	177	3	the	the	DT
cord-354050-kcn67stj	177	4	reasons	reason	NNS
cord-354050-kcn67stj	177	5	for	for	IN
cord-354050-kcn67stj	177	6	the	the	DT
cord-354050-kcn67stj	177	7	disease	disease	NNP
cord-354050-kcn67stj	177	8	association	association	NNP
cord-354050-kcn67stj	177	9	has	have	VBZ
cord-354050-kcn67stj	177	10	remained	remain	VBN
cord-354050-kcn67stj	177	11	elusive	elusive	JJ
cord-354050-kcn67stj	177	12	,	,	,
cord-354050-kcn67stj	177	13	as	as	IN
cord-354050-kcn67stj	177	14	the	the	DT
cord-354050-kcn67stj	177	15	truncated	truncated	JJ
cord-354050-kcn67stj	177	16	isoform	isoform	NN
cord-354050-kcn67stj	177	17	of	of	IN
cord-354050-kcn67stj	177	18	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	177	19	predicted	predict	VBN
cord-354050-kcn67stj	177	20	to	to	TO
cord-354050-kcn67stj	177	21	result	result	VB
cord-354050-kcn67stj	177	22	from	from	IN
cord-354050-kcn67stj	177	23	the	the	DT
cord-354050-kcn67stj	177	24	SNP	SNP	NNP
cord-354050-kcn67stj	177	25	had	have	VBD
cord-354050-kcn67stj	177	26	not	not	RB
cord-354050-kcn67stj	177	27	been	be	VBN
cord-354050-kcn67stj	177	28	detected	detect	VBN
cord-354050-kcn67stj	177	29	in	in	IN
cord-354050-kcn67stj	177	30	cells	cell	NNS
cord-354050-kcn67stj	177	31	or	or	CC
cord-354050-kcn67stj	177	32	individuals	individual	NNS
cord-354050-kcn67stj	177	33	.	.	.
cord-354050-kcn67stj	178	1	It	-PRON-	PRP
cord-354050-kcn67stj	178	2	has	have	VBZ
cord-354050-kcn67stj	178	3	now	now	RB
cord-354050-kcn67stj	178	4	been	be	VBN
cord-354050-kcn67stj	178	5	reported	report	VBN
cord-354050-kcn67stj	178	6	that	that	IN
cord-354050-kcn67stj	178	7	cell	cell	NN
cord-354050-kcn67stj	178	8	lines	line	NNS
cord-354050-kcn67stj	178	9	derived	derive	VBN
cord-354050-kcn67stj	178	10	from	from	IN
cord-354050-kcn67stj	178	11	individuals	individual	NNS
cord-354050-kcn67stj	178	12	who	who	WP
cord-354050-kcn67stj	178	13	are	be	VBP
cord-354050-kcn67stj	178	14	homozygous	homozygous	JJ
cord-354050-kcn67stj	178	15	for	for	IN
cord-354050-kcn67stj	178	16	rs12252-C	rs12252-C	NNP
cord-354050-kcn67stj	178	17	express	express	VB
cord-354050-kcn67stj	178	18	a	a	DT
cord-354050-kcn67stj	178	19	mRNA	mRNA	NNP
cord-354050-kcn67stj	178	20	transcript	transcript	NN
cord-354050-kcn67stj	178	21	encoding	encode	VBG
cord-354050-kcn67stj	178	22	full	full	JJ
cord-354050-kcn67stj	178	23	-	-	HYPH
cord-354050-kcn67stj	178	24	length	length	NN
cord-354050-kcn67stj	178	25	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	178	26	,	,	,
cord-354050-kcn67stj	178	27	whereas	whereas	IN
cord-354050-kcn67stj	178	28	the	the	DT
cord-354050-kcn67stj	178	29	shorter	short	JJR
cord-354050-kcn67stj	178	30	isoform	isoform	NN
cord-354050-kcn67stj	178	31	was	be	VBD
cord-354050-kcn67stj	178	32	not	not	RB
cord-354050-kcn67stj	178	33	found	find	VBN
cord-354050-kcn67stj	178	34	[	[	-LRB-
cord-354050-kcn67stj	178	35	50	50	CD
cord-354050-kcn67stj	178	36	]	]	-RRB-
cord-354050-kcn67stj	178	37	.	.	.
cord-354050-kcn67stj	179	1	Over	over	IN
cord-354050-kcn67stj	179	2	the	the	DT
cord-354050-kcn67stj	179	3	course	course	NN
cord-354050-kcn67stj	179	4	of	of	IN
cord-354050-kcn67stj	179	5	several	several	JJ
cord-354050-kcn67stj	179	6	years	year	NNS
cord-354050-kcn67stj	179	7	,	,	,
cord-354050-kcn67stj	179	8	a	a	DT
cord-354050-kcn67stj	179	9	slew	slew	NN
cord-354050-kcn67stj	179	10	of	of	IN
cord-354050-kcn67stj	179	11	publications	publication	NNS
cord-354050-kcn67stj	179	12	has	have	VBZ
cord-354050-kcn67stj	179	13	either	either	CC
cord-354050-kcn67stj	179	14	confirmed	confirm	VBN
cord-354050-kcn67stj	179	15	or	or	CC
cord-354050-kcn67stj	179	16	refuted	refute	VBD
cord-354050-kcn67stj	179	17	the	the	DT
cord-354050-kcn67stj	179	18	genetic	genetic	JJ
cord-354050-kcn67stj	179	19	association	association	NN
cord-354050-kcn67stj	179	20	between	between	IN
cord-354050-kcn67stj	179	21	rs12252-C	rs12252-C	NNP
cord-354050-kcn67stj	179	22	and	and	CC
cord-354050-kcn67stj	179	23	IAV	IAV	NNP
cord-354050-kcn67stj	179	24	infection	infection	NN
cord-354050-kcn67stj	179	25	outcome	outcome	NN
cord-354050-kcn67stj	179	26	.	.	.
cord-354050-kcn67stj	180	1	A	a	DT
cord-354050-kcn67stj	180	2	recent	recent	JJ
cord-354050-kcn67stj	180	3	and	and	CC
cord-354050-kcn67stj	180	4	comprehensive	comprehensive	JJ
cord-354050-kcn67stj	180	5	study	study	NN
cord-354050-kcn67stj	180	6	now	now	RB
cord-354050-kcn67stj	180	7	links	link	VBZ
cord-354050-kcn67stj	180	8	an	an	DT
cord-354050-kcn67stj	180	9	additional	additional	JJ
cord-354050-kcn67stj	180	10	variant	variant	NN
cord-354050-kcn67stj	180	11	in	in	IN
cord-354050-kcn67stj	180	12	the	the	DT
cord-354050-kcn67stj	180	13	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	180	14	locus	locus	NN
cord-354050-kcn67stj	180	15	to	to	IN
cord-354050-kcn67stj	180	16	severe	severe	JJ
cord-354050-kcn67stj	180	17	influenzaassociated	influenzaassociated	JJ
cord-354050-kcn67stj	180	18	illness	illness	NN
cord-354050-kcn67stj	180	19	in	in	IN
cord-354050-kcn67stj	180	20	three	three	CD
cord-354050-kcn67stj	180	21	independent	independent	JJ
cord-354050-kcn67stj	180	22	cohorts	cohort	NNS
cord-354050-kcn67stj	180	23	,	,	,
cord-354050-kcn67stj	180	24	albeit	albeit	IN
cord-354050-kcn67stj	180	25	the	the	DT
cord-354050-kcn67stj	180	26	SNP	SNP	NNP
cord-354050-kcn67stj	180	27	identified	identify	VBD
cord-354050-kcn67stj	180	28	is	be	VBZ
cord-354050-kcn67stj	180	29	distinct	distinct	JJ
cord-354050-kcn67stj	180	30	from	from	IN
cord-354050-kcn67stj	180	31	rs12252-C.	rs12252-C.	NNP
cord-354050-kcn67stj	180	32	Known	know	VBN
cord-354050-kcn67stj	180	33	as	as	IN
cord-354050-kcn67stj	180	34	rs34481144-A	rs34481144-a	CD
cord-354050-kcn67stj	181	1	,	,	,
cord-354050-kcn67stj	181	2	it	-PRON-	PRP
cord-354050-kcn67stj	181	3	is	be	VBZ
cord-354050-kcn67stj	181	4	found	find	VBN
cord-354050-kcn67stj	181	5	in	in	IN
cord-354050-kcn67stj	181	6	the	the	DT
cord-354050-kcn67stj	181	7	5	5	CD
cord-354050-kcn67stj	181	8	'	'	POS
cord-354050-kcn67stj	181	9	untranslated	untranslated	JJ
cord-354050-kcn67stj	181	10	region	region	NN
cord-354050-kcn67stj	181	11	and	and	CC
cord-354050-kcn67stj	181	12	is	be	VBZ
cord-354050-kcn67stj	181	13	linked	link	VBN
cord-354050-kcn67stj	181	14	to	to	TO
cord-354050-kcn67stj	181	15	lower	lower	VB
cord-354050-kcn67stj	181	16	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	181	17	protein	protein	NN
cord-354050-kcn67stj	181	18	levels	level	NNS
cord-354050-kcn67stj	181	19	in	in	IN
cord-354050-kcn67stj	181	20	cells	cell	NNS
cord-354050-kcn67stj	181	21	[	[	-LRB-
cord-354050-kcn67stj	181	22	72	72	CD
cord-354050-kcn67stj	181	23	]	]	-RRB-
cord-354050-kcn67stj	181	24	.	.	.
cord-354050-kcn67stj	182	1	Experimental	experimental	JJ
cord-354050-kcn67stj	182	2	evidence	evidence	NN
cord-354050-kcn67stj	182	3	showed	show	VBD
cord-354050-kcn67stj	182	4	that	that	IN
cord-354050-kcn67stj	182	5	the	the	DT
cord-354050-kcn67stj	182	6	SNP	SNP	NNP
cord-354050-kcn67stj	182	7	controls	control	VBZ
cord-354050-kcn67stj	182	8	gene	gene	NN
cord-354050-kcn67stj	182	9	promoter	promoter	NN
cord-354050-kcn67stj	182	10	activity	activity	NN
cord-354050-kcn67stj	182	11	via	via	IN
cord-354050-kcn67stj	182	12	decreased	decrease	VBN
cord-354050-kcn67stj	182	13	binding	binding	NN
cord-354050-kcn67stj	182	14	of	of	IN
cord-354050-kcn67stj	182	15	transcription	transcription	NN
cord-354050-kcn67stj	182	16	factor	factor	NN
cord-354050-kcn67stj	182	17	IRF3	IRF3	NNP
cord-354050-kcn67stj	182	18	and	and	CC
cord-354050-kcn67stj	182	19	increased	increase	VBN
cord-354050-kcn67stj	182	20	binding	binding	NN
cord-354050-kcn67stj	182	21	of	of	IN
cord-354050-kcn67stj	182	22	CTCF	CTCF	NNP
cord-354050-kcn67stj	182	23	,	,	,
cord-354050-kcn67stj	182	24	which	which	WDT
cord-354050-kcn67stj	182	25	promote	promote	VBP
cord-354050-kcn67stj	182	26	and	and	CC
cord-354050-kcn67stj	182	27	repress	repress	VB
cord-354050-kcn67stj	182	28	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	182	29	transcription	transcription	NN
cord-354050-kcn67stj	182	30	,	,	,
cord-354050-kcn67stj	182	31	respectively	respectively	RB
cord-354050-kcn67stj	182	32	.	.	.
cord-354050-kcn67stj	183	1	In	in	IN
cord-354050-kcn67stj	183	2	agreement	agreement	NN
cord-354050-kcn67stj	183	3	with	with	IN
cord-354050-kcn67stj	183	4	the	the	DT
cord-354050-kcn67stj	183	5	previous	previous	JJ
cord-354050-kcn67stj	183	6	finding	finding	NN
cord-354050-kcn67stj	183	7	that	that	IN
cord-354050-kcn67stj	183	8	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	183	9	preserves	preserve	VBZ
cord-354050-kcn67stj	183	10	antiviral	antiviral	JJ
cord-354050-kcn67stj	183	11	CD8	CD8	NNP
cord-354050-kcn67stj	183	12	+	+	CC
cord-354050-kcn67stj	183	13	T	T	NNP
cord-354050-kcn67stj	183	14	cells	cell	NNS
cord-354050-kcn67stj	183	15	[	[	-LRB-
cord-354050-kcn67stj	183	16	65	65	CD
cord-354050-kcn67stj	183	17	]	]	-RRB-
cord-354050-kcn67stj	183	18	,	,	,
cord-354050-kcn67stj	183	19	individuals	individual	NNS
cord-354050-kcn67stj	183	20	harboring	harbor	VBG
cord-354050-kcn67stj	183	21	rs34481144-A	rs34481144-A	,
cord-354050-kcn67stj	183	22	contained	contain	VBN
cord-354050-kcn67stj	183	23	reduced	reduced	JJ
cord-354050-kcn67stj	183	24	numbers	number	NNS
cord-354050-kcn67stj	183	25	of	of	IN
cord-354050-kcn67stj	183	26	these	these	DT
cord-354050-kcn67stj	183	27	cells	cell	NNS
cord-354050-kcn67stj	183	28	in	in	IN
cord-354050-kcn67stj	183	29	lung	lung	NN
cord-354050-kcn67stj	183	30	airways	airway	NNS
cord-354050-kcn67stj	183	31	during	during	IN
cord-354050-kcn67stj	183	32	infection	infection	NN
cord-354050-kcn67stj	183	33	[	[	-LRB-
cord-354050-kcn67stj	183	34	72	72	CD
cord-354050-kcn67stj	183	35	]	]	-RRB-
cord-354050-kcn67stj	183	36	.	.	.
cord-354050-kcn67stj	184	1	The	the	DT
cord-354050-kcn67stj	184	2	evolutionary	evolutionary	JJ
cord-354050-kcn67stj	184	3	pressures	pressure	NNS
cord-354050-kcn67stj	184	4	responsible	responsible	JJ
cord-354050-kcn67stj	184	5	for	for	IN
cord-354050-kcn67stj	184	6	the	the	DT
cord-354050-kcn67stj	184	7	maintenance	maintenance	NN
cord-354050-kcn67stj	184	8	of	of	IN
cord-354050-kcn67stj	184	9	this	this	DT
cord-354050-kcn67stj	184	10	'	'	``
cord-354050-kcn67stj	184	11	defective	defective	JJ
cord-354050-kcn67stj	184	12	'	'	''
cord-354050-kcn67stj	184	13	allele	allele	NN
cord-354050-kcn67stj	184	14	in	in	IN
cord-354050-kcn67stj	184	15	humans	human	NNS
cord-354050-kcn67stj	184	16	are	be	VBP
cord-354050-kcn67stj	184	17	unclear	unclear	JJ
cord-354050-kcn67stj	184	18	,	,	,
cord-354050-kcn67stj	184	19	but	but	CC
cord-354050-kcn67stj	184	20	its	-PRON-	PRP$
cord-354050-kcn67stj	184	21	existence	existence	NN
cord-354050-kcn67stj	184	22	may	may	MD
cord-354050-kcn67stj	184	23	allude	allude	VB
cord-354050-kcn67stj	184	24	to	to	IN
cord-354050-kcn67stj	184	25	the	the	DT
cord-354050-kcn67stj	184	26	involvement	involvement	NN
cord-354050-kcn67stj	184	27	of	of	IN
cord-354050-kcn67stj	184	28	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	184	29	in	in	IN
cord-354050-kcn67stj	184	30	cellular	cellular	JJ
cord-354050-kcn67stj	184	31	processes	process	NNS
cord-354050-kcn67stj	184	32	requiring	require	VBG
cord-354050-kcn67stj	184	33	fine	fine	RB
cord-354050-kcn67stj	184	34	-	-	HYPH
cord-354050-kcn67stj	184	35	tuned	tune	VBN
cord-354050-kcn67stj	184	36	protein	protein	NN
cord-354050-kcn67stj	184	37	expression	expression	NN
cord-354050-kcn67stj	184	38	.	.	.
cord-354050-kcn67stj	185	1	Before	before	IN
cord-354050-kcn67stj	185	2	it	-PRON-	PRP
cord-354050-kcn67stj	185	3	was	be	VBD
cord-354050-kcn67stj	185	4	realized	realize	VBN
cord-354050-kcn67stj	185	5	that	that	IN
cord-354050-kcn67stj	185	6	IFITM	IFITM	NNP
cord-354050-kcn67stj	185	7	proteins	protein	NNS
cord-354050-kcn67stj	185	8	perform	perform	VBP
cord-354050-kcn67stj	185	9	broad	broad	JJ
cord-354050-kcn67stj	185	10	-	-	HYPH
cord-354050-kcn67stj	185	11	spectrum	spectrum	NN
cord-354050-kcn67stj	185	12	antiviral	antiviral	JJ
cord-354050-kcn67stj	185	13	activities	activity	NNS
cord-354050-kcn67stj	185	14	,	,	,
cord-354050-kcn67stj	185	15	they	-PRON-	PRP
cord-354050-kcn67stj	185	16	were	be	VBD
cord-354050-kcn67stj	185	17	implicated	implicate	VBN
cord-354050-kcn67stj	185	18	in	in	IN
cord-354050-kcn67stj	185	19	pathways	pathway	NNS
cord-354050-kcn67stj	185	20	important	important	JJ
cord-354050-kcn67stj	185	21	to	to	IN
cord-354050-kcn67stj	185	22	embryonic	embryonic	JJ
cord-354050-kcn67stj	185	23	development	development	NN
cord-354050-kcn67stj	185	24	and	and	CC
cord-354050-kcn67stj	185	25	cancer	cancer	NN
cord-354050-kcn67stj	185	26	(	(	-LRB-
cord-354050-kcn67stj	185	27	exhaustively	exhaustively	RB
cord-354050-kcn67stj	185	28	reviewed	review	VBN
cord-354050-kcn67stj	185	29	in	in	IN
cord-354050-kcn67stj	185	30	[	[	-LRB-
cord-354050-kcn67stj	185	31	73	73	CD
cord-354050-kcn67stj	185	32	]	]	-RRB-
cord-354050-kcn67stj	185	33	)	)	-RRB-
cord-354050-kcn67stj	185	34	.	.	.
cord-354050-kcn67stj	186	1	A	a	DT
cord-354050-kcn67stj	186	2	crucial	crucial	JJ
cord-354050-kcn67stj	186	3	contribution	contribution	NN
cord-354050-kcn67stj	186	4	to	to	IN
cord-354050-kcn67stj	186	5	developmental	developmental	JJ
cord-354050-kcn67stj	186	6	processes	process	NNS
cord-354050-kcn67stj	186	7	seems	seem	VBZ
cord-354050-kcn67stj	186	8	unlikely	unlikely	JJ
cord-354050-kcn67stj	186	9	,	,	,
cord-354050-kcn67stj	186	10	since	since	IN
cord-354050-kcn67stj	186	11	transgenic	transgenic	JJ
cord-354050-kcn67stj	186	12	mice	mouse	NNS
cord-354050-kcn67stj	186	13	in	in	IN
cord-354050-kcn67stj	186	14	which	which	WDT
cord-354050-kcn67stj	186	15	the	the	DT
cord-354050-kcn67stj	186	16	murine	murine	JJ
cord-354050-kcn67stj	186	17	ifitm	ifitm	NN
cord-354050-kcn67stj	186	18	locus	locus	NN
cord-354050-kcn67stj	186	19	is	be	VBZ
cord-354050-kcn67stj	186	20	knocked	knock	VBN
cord-354050-kcn67stj	186	21	out	out	RP
cord-354050-kcn67stj	186	22	exhibit	exhibit	NN
cord-354050-kcn67stj	186	23	no	no	DT
cord-354050-kcn67stj	186	24	obvious	obvious	JJ
cord-354050-kcn67stj	186	25	abnormalities	abnormality	NNS
cord-354050-kcn67stj	186	26	apart	apart	RB
cord-354050-kcn67stj	186	27	from	from	IN
cord-354050-kcn67stj	186	28	being	be	VBG
cord-354050-kcn67stj	186	29	fat	fat	JJ
cord-354050-kcn67stj	186	30	,	,	,
cord-354050-kcn67stj	186	31	suggesting	suggest	VBG
cord-354050-kcn67stj	186	32	a	a	DT
cord-354050-kcn67stj	186	33	metabolic	metabolic	JJ
cord-354050-kcn67stj	186	34	irregularity	irregularity	NN
cord-354050-kcn67stj	186	35	[	[	-LRB-
cord-354050-kcn67stj	186	36	74	74	CD
cord-354050-kcn67stj	186	37	]	]	-RRB-
cord-354050-kcn67stj	186	38	.	.	.
cord-354050-kcn67stj	187	1	There	there	EX
cord-354050-kcn67stj	187	2	is	be	VBZ
cord-354050-kcn67stj	187	3	ample	ample	JJ
cord-354050-kcn67stj	187	4	evidence	evidence	NN
cord-354050-kcn67stj	187	5	,	,	,
cord-354050-kcn67stj	187	6	on	on	IN
cord-354050-kcn67stj	187	7	the	the	DT
cord-354050-kcn67stj	187	8	other	other	JJ
cord-354050-kcn67stj	187	9	hand	hand	NN
cord-354050-kcn67stj	187	10	,	,	,
cord-354050-kcn67stj	187	11	for	for	IN
cord-354050-kcn67stj	187	12	both	both	DT
cord-354050-kcn67stj	187	13	positive	positive	JJ
cord-354050-kcn67stj	187	14	and	and	CC
cord-354050-kcn67stj	187	15	negative	negative	JJ
cord-354050-kcn67stj	187	16	regulation	regulation	NN
cord-354050-kcn67stj	187	17	of	of	IN
cord-354050-kcn67stj	187	18	IFITM	IFITM	NNP
cord-354050-kcn67stj	187	19	expression	expression	NN
cord-354050-kcn67stj	187	20	during	during	IN
cord-354050-kcn67stj	187	21	tumorigenesis	tumorigenesis	NN
cord-354050-kcn67stj	187	22	.	.	.
cord-354050-kcn67stj	188	1	While	while	IN
cord-354050-kcn67stj	188	2	detailed	detailed	JJ
cord-354050-kcn67stj	188	3	descriptions	description	NNS
cord-354050-kcn67stj	188	4	were	be	VBD
cord-354050-kcn67stj	188	5	previously	previously	RB
cord-354050-kcn67stj	188	6	lacking	lack	VBG
cord-354050-kcn67stj	188	7	,	,	,
cord-354050-kcn67stj	188	8	recent	recent	JJ
cord-354050-kcn67stj	188	9	developments	development	NNS
cord-354050-kcn67stj	188	10	have	have	VBP
cord-354050-kcn67stj	188	11	provided	provide	VBN
cord-354050-kcn67stj	188	12	a	a	DT
cord-354050-kcn67stj	188	13	mechanistic	mechanistic	JJ
cord-354050-kcn67stj	188	14	grounding	grounding	NN
cord-354050-kcn67stj	188	15	to	to	IN
cord-354050-kcn67stj	188	16	many	many	JJ
cord-354050-kcn67stj	188	17	observations	observation	NNS
cord-354050-kcn67stj	188	18	linking	link	VBG
cord-354050-kcn67stj	188	19	IFITM	ifitm	NN
cord-354050-kcn67stj	188	20	proteins	protein	NNS
cord-354050-kcn67stj	188	21	to	to	IN
cord-354050-kcn67stj	188	22	cell	cell	NN
cord-354050-kcn67stj	188	23	proliferation	proliferation	NN
cord-354050-kcn67stj	188	24	,	,	,
cord-354050-kcn67stj	188	25	adhesion	adhesion	NN
cord-354050-kcn67stj	188	26	,	,	,
cord-354050-kcn67stj	188	27	and	and	CC
cord-354050-kcn67stj	188	28	migration	migration	NN
cord-354050-kcn67stj	188	29	.	.	.
cord-354050-kcn67stj	189	1	In	in	IN
cord-354050-kcn67stj	189	2	addition	addition	NN
cord-354050-kcn67stj	189	3	to	to	IN
cord-354050-kcn67stj	189	4	the	the	DT
cord-354050-kcn67stj	189	5	interferon	interferon	NN
cord-354050-kcn67stj	189	6	signaling	signal	VBG
cord-354050-kcn67stj	189	7	pathways	pathway	NNS
cord-354050-kcn67stj	189	8	,	,	,
cord-354050-kcn67stj	189	9	IFITM	IFITM	NNP
cord-354050-kcn67stj	189	10	gene	gene	NN
cord-354050-kcn67stj	189	11	expression	expression	NN
cord-354050-kcn67stj	189	12	is	be	VBZ
cord-354050-kcn67stj	189	13	controlled	control	VBN
cord-354050-kcn67stj	189	14	by	by	IN
cord-354050-kcn67stj	189	15	a	a	DT
cord-354050-kcn67stj	189	16	number	number	NN
cord-354050-kcn67stj	189	17	of	of	IN
cord-354050-kcn67stj	189	18	cascades	cascade	NNS
cord-354050-kcn67stj	189	19	involved	involve	VBN
cord-354050-kcn67stj	189	20	in	in	IN
cord-354050-kcn67stj	189	21	cellular	cellular	JJ
cord-354050-kcn67stj	189	22	homeostasis	homeostasis	NN
cord-354050-kcn67stj	189	23	(	(	-LRB-
cord-354050-kcn67stj	189	24	Fig	Fig	NNP
cord-354050-kcn67stj	189	25	.	.	NNP
cord-354050-kcn67stj	189	26	2	2	CD
cord-354050-kcn67stj	189	27	)	)	-RRB-
cord-354050-kcn67stj	189	28	.	.	.
cord-354050-kcn67stj	190	1	For	for	IN
cord-354050-kcn67stj	190	2	example	example	NN
cord-354050-kcn67stj	190	3	,	,	,
cord-354050-kcn67stj	190	4	growth	growth	NN
cord-354050-kcn67stj	190	5	factor	factor	NN
cord-354050-kcn67stj	190	6	receptors	receptor	NNS
cord-354050-kcn67stj	190	7	lead	lead	VBP
cord-354050-kcn67stj	190	8	to	to	IN
cord-354050-kcn67stj	190	9	downstream	downstream	JJ
cord-354050-kcn67stj	190	10	upregulation	upregulation	NN
cord-354050-kcn67stj	190	11	of	of	IN
cord-354050-kcn67stj	190	12	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	190	13	upon	upon	IN
cord-354050-kcn67stj	190	14	triggering	trigger	VBG
cord-354050-kcn67stj	190	15	by	by	IN
cord-354050-kcn67stj	190	16	insulin	insulin	NN
cord-354050-kcn67stj	190	17	-	-	HYPH
cord-354050-kcn67stj	190	18	like	like	JJ
cord-354050-kcn67stj	190	19	growth	growth	NN
cord-354050-kcn67stj	190	20	factor-1	factor-1	NNP
cord-354050-kcn67stj	190	21	(	(	-LRB-
cord-354050-kcn67stj	190	22	IGF1	IGF1	NNP
cord-354050-kcn67stj	190	23	)	)	-RRB-
cord-354050-kcn67stj	190	24	,	,	,
cord-354050-kcn67stj	190	25	which	which	WDT
cord-354050-kcn67stj	190	26	relies	rely	VBZ
cord-354050-kcn67stj	190	27	on	on	IN
cord-354050-kcn67stj	190	28	signaling	signal	VBG
cord-354050-kcn67stj	190	29	via	via	IN
cord-354050-kcn67stj	190	30	phosphatidylinositol-3-kinase	phosphatidylinositol-3-kinase	NNP
cord-354050-kcn67stj	190	31	(	(	-LRB-
cord-354050-kcn67stj	190	32	PI3	PI3	NNP
cord-354050-kcn67stj	190	33	K	K	NNP
cord-354050-kcn67stj	190	34	)	)	-RRB-
cord-354050-kcn67stj	190	35	and	and	CC
cord-354050-kcn67stj	190	36	Akt	Akt	NNP
cord-354050-kcn67stj	190	37	kinase	kinase	NN
cord-354050-kcn67stj	190	38	.	.	.
cord-354050-kcn67stj	191	1	In	in	IN
cord-354050-kcn67stj	191	2	gastric	gastric	JJ
cord-354050-kcn67stj	191	3	cancer	cancer	NN
cord-354050-kcn67stj	191	4	cohorts	cohort	NNS
cord-354050-kcn67stj	191	5	,	,	,
cord-354050-kcn67stj	191	6	the	the	DT
cord-354050-kcn67stj	191	7	upregulation	upregulation	NN
cord-354050-kcn67stj	191	8	of	of	IN
cord-354050-kcn67stj	191	9	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	191	10	is	be	VBZ
cord-354050-kcn67stj	191	11	associated	associate	VBN
cord-354050-kcn67stj	191	12	with	with	IN
cord-354050-kcn67stj	191	13	accelerated	accelerated	JJ
cord-354050-kcn67stj	191	14	disease	disease	NN
cord-354050-kcn67stj	191	15	progression	progression	NN
cord-354050-kcn67stj	191	16	and	and	CC
cord-354050-kcn67stj	191	17	shorter	short	JJR
cord-354050-kcn67stj	191	18	survival	survival	NN
cord-354050-kcn67stj	191	19	time	time	NN
cord-354050-kcn67stj	191	20	[	[	-LRB-
cord-354050-kcn67stj	191	21	75	75	CD
cord-354050-kcn67stj	191	22	]	]	-RRB-
cord-354050-kcn67stj	191	23	.	.	.
cord-354050-kcn67stj	192	1	Silencing	silencing	NN
cord-354050-kcn67stj	192	2	of	of	IN
cord-354050-kcn67stj	192	3	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	192	4	in	in	IN
cord-354050-kcn67stj	192	5	gastric	gastric	JJ
cord-354050-kcn67stj	192	6	cancer	cancer	NN
cord-354050-kcn67stj	192	7	cells	cell	NNS
cord-354050-kcn67stj	192	8	decreased	decrease	VBD
cord-354050-kcn67stj	192	9	cell	cell	NN
cord-354050-kcn67stj	192	10	proliferation	proliferation	NN
cord-354050-kcn67stj	192	11	,	,	,
cord-354050-kcn67stj	192	12	migration	migration	NN
cord-354050-kcn67stj	192	13	,	,	,
cord-354050-kcn67stj	192	14	and	and	CC
cord-354050-kcn67stj	192	15	metastasis	metastasis	NN
cord-354050-kcn67stj	192	16	,	,	,
cord-354050-kcn67stj	192	17	while	while	IN
cord-354050-kcn67stj	192	18	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	192	19	depletion	depletion	NN
cord-354050-kcn67stj	192	20	in	in	IN
cord-354050-kcn67stj	192	21	a	a	DT
cord-354050-kcn67stj	192	22	mouse	mouse	NN
cord-354050-kcn67stj	192	23	model	model	NN
cord-354050-kcn67stj	192	24	resulted	result	VBD
cord-354050-kcn67stj	192	25	in	in	IN
cord-354050-kcn67stj	192	26	dramatic	dramatic	JJ
cord-354050-kcn67stj	192	27	decreases	decrease	NNS
cord-354050-kcn67stj	192	28	in	in	IN
cord-354050-kcn67stj	192	29	tumor	tumor	NN
cord-354050-kcn67stj	192	30	size	size	NN
cord-354050-kcn67stj	192	31	[	[	-LRB-
cord-354050-kcn67stj	192	32	75	75	CD
cord-354050-kcn67stj	192	33	]	]	-RRB-
cord-354050-kcn67stj	192	34	.	.	.
cord-354050-kcn67stj	193	1	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	193	2	has	have	VBZ
cord-354050-kcn67stj	193	3	also	also	RB
cord-354050-kcn67stj	193	4	been	be	VBN
cord-354050-kcn67stj	193	5	functionally	functionally	RB
cord-354050-kcn67stj	193	6	implicated	implicate	VBN
cord-354050-kcn67stj	193	7	in	in	IN
cord-354050-kcn67stj	193	8	this	this	DT
cord-354050-kcn67stj	193	9	cancer	cancer	NN
cord-354050-kcn67stj	193	10	type	type	NN
cord-354050-kcn67stj	193	11	,	,	,
cord-354050-kcn67stj	193	12	as	as	IN
cord-354050-kcn67stj	193	13	its	-PRON-	PRP$
cord-354050-kcn67stj	193	14	knockdown	knockdown	NN
cord-354050-kcn67stj	193	15	suppressed	suppress	VBD
cord-354050-kcn67stj	193	16	tumor	tumor	NN
cord-354050-kcn67stj	193	17	cell	cell	NN
cord-354050-kcn67stj	193	18	migration	migration	NN
cord-354050-kcn67stj	193	19	,	,	,
cord-354050-kcn67stj	193	20	invasion	invasion	NN
cord-354050-kcn67stj	193	21	and	and	CC
cord-354050-kcn67stj	193	22	proliferation	proliferation	NN
cord-354050-kcn67stj	193	23	capacity	capacity	NN
cord-354050-kcn67stj	193	24	[	[	-LRB-
cord-354050-kcn67stj	193	25	76	76	CD
cord-354050-kcn67stj	193	26	]	]	-RRB-
cord-354050-kcn67stj	193	27	.	.	.
cord-354050-kcn67stj	194	1	There	there	EX
cord-354050-kcn67stj	194	2	is	be	VBZ
cord-354050-kcn67stj	194	3	also	also	RB
cord-354050-kcn67stj	194	4	evidence	evidence	NN
cord-354050-kcn67stj	194	5	that	that	IN
cord-354050-kcn67stj	194	6	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	194	7	acts	act	VBZ
cord-354050-kcn67stj	194	8	indirectly	indirectly	RB
cord-354050-kcn67stj	194	9	to	to	TO
cord-354050-kcn67stj	194	10	affect	affect	VB
cord-354050-kcn67stj	194	11	these	these	DT
cord-354050-kcn67stj	194	12	cellular	cellular	JJ
cord-354050-kcn67stj	194	13	properties	property	NNS
cord-354050-kcn67stj	194	14	through	through	IN
cord-354050-kcn67stj	194	15	regulation	regulation	NN
cord-354050-kcn67stj	194	16	of	of	IN
cord-354050-kcn67stj	194	17	other	other	JJ
cord-354050-kcn67stj	194	18	cellular	cellular	JJ
cord-354050-kcn67stj	194	19	proteins	protein	NNS
cord-354050-kcn67stj	194	20	,	,	,
cord-354050-kcn67stj	194	21	such	such	JJ
cord-354050-kcn67stj	194	22	as	as	IN
cord-354050-kcn67stj	194	23	osteopontin	osteopontin	NNP
cord-354050-kcn67stj	194	24	[	[	-LRB-
cord-354050-kcn67stj	194	25	77	77	CD
cord-354050-kcn67stj	194	26	]	]	-RRB-
cord-354050-kcn67stj	194	27	.	.	.
cord-354050-kcn67stj	195	1	Recently	recently	RB
cord-354050-kcn67stj	195	2	,	,	,
cord-354050-kcn67stj	195	3	the	the	DT
cord-354050-kcn67stj	195	4	involvement	involvement	NN
cord-354050-kcn67stj	195	5	of	of	IN
cord-354050-kcn67stj	195	6	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	195	7	in	in	IN
cord-354050-kcn67stj	195	8	cancer	cancer	NN
cord-354050-kcn67stj	195	9	was	be	VBD
cord-354050-kcn67stj	195	10	further	further	RB
cord-354050-kcn67stj	195	11	extended	extend	VBN
cord-354050-kcn67stj	195	12	to	to	TO
cord-354050-kcn67stj	195	13	include	include	VB
cord-354050-kcn67stj	195	14	spatial	spatial	JJ
cord-354050-kcn67stj	195	15	regulation	regulation	NN
cord-354050-kcn67stj	195	16	of	of	IN
cord-354050-kcn67stj	195	17	the	the	DT
cord-354050-kcn67stj	195	18	Src	Src	NNP
cord-354050-kcn67stj	195	19	oncoprotein	oncoprotein	NNP
cord-354050-kcn67stj	195	20	.	.	.
cord-354050-kcn67stj	196	1	The	the	DT
cord-354050-kcn67stj	196	2	trafficking	trafficking	NN
cord-354050-kcn67stj	196	3	of	of	IN
cord-354050-kcn67stj	196	4	Src	Src	NNP
cord-354050-kcn67stj	196	5	between	between	IN
cord-354050-kcn67stj	196	6	focal	focal	JJ
cord-354050-kcn67stj	196	7	adhesions	adhesion	NNS
cord-354050-kcn67stj	196	8	and	and	CC
cord-354050-kcn67stj	196	9	the	the	DT
cord-354050-kcn67stj	196	10	cell	cell	NN
cord-354050-kcn67stj	196	11	interior	interior	NN
cord-354050-kcn67stj	196	12	,	,	,
cord-354050-kcn67stj	196	13	which	which	WDT
cord-354050-kcn67stj	196	14	is	be	VBZ
cord-354050-kcn67stj	196	15	regulated	regulate	VBN
cord-354050-kcn67stj	196	16	by	by	IN
cord-354050-kcn67stj	196	17	activating	activate	VBG
cord-354050-kcn67stj	196	18	molecule	molecule	NN
cord-354050-kcn67stj	196	19	in	in	IN
cord-354050-kcn67stj	196	20	Beclin1-regulated	Beclin1-regulated	NNP
cord-354050-kcn67stj	196	21	autophagy	autophagy	NN
cord-354050-kcn67stj	196	22	(	(	-LRB-
cord-354050-kcn67stj	196	23	Ambra1	Ambra1	NNP
cord-354050-kcn67stj	196	24	)	)	-RRB-
cord-354050-kcn67stj	196	25	and	and	CC
cord-354050-kcn67stj	196	26	focal	focal	JJ
cord-354050-kcn67stj	196	27	adhesion	adhesion	NN
cord-354050-kcn67stj	196	28	kinase	kinase	NN
cord-354050-kcn67stj	196	29	(	(	-LRB-
cord-354050-kcn67stj	196	30	FAK	FAK	NNP
cord-354050-kcn67stj	196	31	)	)	-RRB-
cord-354050-kcn67stj	196	32	,	,	,
cord-354050-kcn67stj	196	33	is	be	VBZ
cord-354050-kcn67stj	196	34	important	important	JJ
cord-354050-kcn67stj	196	35	for	for	IN
cord-354050-kcn67stj	196	36	cell	cell	NN
cord-354050-kcn67stj	196	37	migration	migration	NN
cord-354050-kcn67stj	196	38	and	and	CC
cord-354050-kcn67stj	196	39	metastasis	metastasis	NN
cord-354050-kcn67stj	196	40	.	.	.
cord-354050-kcn67stj	197	1	Ambra1	Ambra1	NNP
cord-354050-kcn67stj	197	2	redirects	redirect	VBZ
cord-354050-kcn67stj	197	3	Src	Src	NNP
cord-354050-kcn67stj	197	4	towards	towards	IN
cord-354050-kcn67stj	197	5	autophagosomes	autophagosomes	NNP
cord-354050-kcn67stj	197	6	to	to	IN
cord-354050-kcn67stj	197	7	disfavor	disfavor	NN
cord-354050-kcn67stj	197	8	substrate	substrate	NN
cord-354050-kcn67stj	197	9	attachment	attachment	NN
cord-354050-kcn67stj	197	10	and	and	CC
cord-354050-kcn67stj	197	11	favor	favor	NN
cord-354050-kcn67stj	197	12	cell	cell	NN
cord-354050-kcn67stj	197	13	movement	movement	NN
cord-354050-kcn67stj	197	14	in	in	IN
cord-354050-kcn67stj	197	15	an	an	DT
cord-354050-kcn67stj	197	16	IFITM3-dependent	ifitm3-dependent	CD
cord-354050-kcn67stj	197	17	manner	manner	NN
cord-354050-kcn67stj	198	1	[	[	-LRB-
cord-354050-kcn67stj	198	2	78	78	CD
cord-354050-kcn67stj	198	3	]	]	-RRB-
cord-354050-kcn67stj	198	4	(	(	-LRB-
cord-354050-kcn67stj	198	5	Fig	Fig	NNP
cord-354050-kcn67stj	198	6	.	.	NNP
cord-354050-kcn67stj	198	7	2	2	CD
cord-354050-kcn67stj	198	8	)	)	-RRB-
cord-354050-kcn67stj	198	9	.	.	.
cord-354050-kcn67stj	199	1	Collectively	collectively	RB
cord-354050-kcn67stj	199	2	,	,	,
cord-354050-kcn67stj	199	3	the	the	DT
cord-354050-kcn67stj	199	4	twin	twin	JJ
cord-354050-kcn67stj	199	5	antiviral	antiviral	JJ
cord-354050-kcn67stj	199	6	proteins	protein	NNS
cord-354050-kcn67stj	199	7	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	199	8	and	and	CC
cord-354050-kcn67stj	199	9	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	199	10	may	may	MD
cord-354050-kcn67stj	199	11	serve	serve	VB
cord-354050-kcn67stj	199	12	as	as	IN
cord-354050-kcn67stj	199	13	biomarkers	biomarker	NNS
cord-354050-kcn67stj	199	14	for	for	IN
cord-354050-kcn67stj	199	15	tumorigenic	tumorigenic	JJ
cord-354050-kcn67stj	199	16	phenotypes	phenotype	NNS
cord-354050-kcn67stj	199	17	as	as	RB
cord-354050-kcn67stj	199	18	well	well	RB
cord-354050-kcn67stj	199	19	as	as	IN
cord-354050-kcn67stj	199	20	targets	target	NNS
cord-354050-kcn67stj	199	21	for	for	IN
cord-354050-kcn67stj	199	22	anticancer	anticancer	JJ
cord-354050-kcn67stj	199	23	interventions	intervention	NNS
cord-354050-kcn67stj	199	24	.	.	.
cord-354050-kcn67stj	200	1	It	-PRON-	PRP
cord-354050-kcn67stj	200	2	remains	remain	VBZ
cord-354050-kcn67stj	200	3	to	to	TO
cord-354050-kcn67stj	200	4	be	be	VB
cord-354050-kcn67stj	200	5	determined	determine	VBN
cord-354050-kcn67stj	200	6	which	which	WDT
cord-354050-kcn67stj	200	7	domains	domain	NNS
cord-354050-kcn67stj	200	8	of	of	IN
cord-354050-kcn67stj	200	9	IFITM	IFITM	NNP
cord-354050-kcn67stj	200	10	proteins	protein	NNS
cord-354050-kcn67stj	200	11	are	be	VBP
cord-354050-kcn67stj	200	12	involved	involve	VBN
cord-354050-kcn67stj	200	13	in	in	IN
cord-354050-kcn67stj	200	14	the	the	DT
cord-354050-kcn67stj	200	15	control	control	NN
cord-354050-kcn67stj	200	16	of	of	IN
cord-354050-kcn67stj	200	17	cellular	cellular	JJ
cord-354050-kcn67stj	200	18	properties	property	NNS
cord-354050-kcn67stj	200	19	and	and	CC
cord-354050-kcn67stj	200	20	if	if	IN
cord-354050-kcn67stj	200	21	they	-PRON-	PRP
cord-354050-kcn67stj	200	22	overlap	overlap	VBP
cord-354050-kcn67stj	200	23	with	with	IN
cord-354050-kcn67stj	200	24	those	those	DT
cord-354050-kcn67stj	200	25	known	know	VBN
cord-354050-kcn67stj	200	26	to	to	TO
cord-354050-kcn67stj	200	27	be	be	VB
cord-354050-kcn67stj	200	28	involved	involve	VBN
cord-354050-kcn67stj	200	29	in	in	IN
cord-354050-kcn67stj	200	30	antiviral	antiviral	JJ
cord-354050-kcn67stj	200	31	immunity	immunity	NN
cord-354050-kcn67stj	200	32	.	.	.
cord-354050-kcn67stj	201	1	For	for	IN
cord-354050-kcn67stj	201	2	example	example	NN
cord-354050-kcn67stj	201	3	,	,	,
cord-354050-kcn67stj	201	4	just	just	RB
cord-354050-kcn67stj	201	5	as	as	IN
cord-354050-kcn67stj	201	6	the	the	DT
cord-354050-kcn67stj	201	7	subcellular	subcellular	JJ
cord-354050-kcn67stj	201	8	localization	localization	NN
cord-354050-kcn67stj	201	9	of	of	IN
cord-354050-kcn67stj	201	10	IFITM	IFITM	NNP
cord-354050-kcn67stj	201	11	proteins	protein	NNS
cord-354050-kcn67stj	201	12	is	be	VBZ
cord-354050-kcn67stj	201	13	important	important	JJ
cord-354050-kcn67stj	201	14	to	to	IN
cord-354050-kcn67stj	201	15	their	-PRON-	PRP$
cord-354050-kcn67stj	201	16	antiviral	antiviral	JJ
cord-354050-kcn67stj	201	17	activities	activity	NNS
cord-354050-kcn67stj	201	18	[	[	-LRB-
cord-354050-kcn67stj	201	19	11	11	CD
cord-354050-kcn67stj	201	20	]	]	-RRB-
cord-354050-kcn67stj	201	21	,	,	,
cord-354050-kcn67stj	201	22	it	-PRON-	PRP
cord-354050-kcn67stj	201	23	may	may	MD
cord-354050-kcn67stj	201	24	also	also	RB
cord-354050-kcn67stj	201	25	affect	affect	VB
cord-354050-kcn67stj	201	26	their	-PRON-	PRP$
cord-354050-kcn67stj	201	27	involvement	involvement	NN
cord-354050-kcn67stj	201	28	in	in	IN
cord-354050-kcn67stj	201	29	cellular	cellular	JJ
cord-354050-kcn67stj	201	30	housekeeping	housekeeping	NN
cord-354050-kcn67stj	201	31	functions	function	NNS
cord-354050-kcn67stj	201	32	.	.	.
cord-354050-kcn67stj	202	1	As	as	IN
cord-354050-kcn67stj	202	2	a	a	DT
cord-354050-kcn67stj	202	3	proof	proof	NN
cord-354050-kcn67stj	202	4	of	of	IN
cord-354050-kcn67stj	202	5	principle	principle	NN
cord-354050-kcn67stj	202	6	,	,	,
cord-354050-kcn67stj	202	7	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	202	8	can	can	MD
cord-354050-kcn67stj	202	9	act	act	VB
cord-354050-kcn67stj	202	10	as	as	IN
cord-354050-kcn67stj	202	11	a	a	DT
cord-354050-kcn67stj	202	12	cell	cell	NN
cord-354050-kcn67stj	202	13	surface	surface	NN
cord-354050-kcn67stj	202	14	receptor	receptor	NN
cord-354050-kcn67stj	202	15	for	for	IN
cord-354050-kcn67stj	202	16	a	a	DT
cord-354050-kcn67stj	202	17	secreted	secrete	VBN
cord-354050-kcn67stj	202	18	form	form	NN
cord-354050-kcn67stj	202	19	of	of	IN
cord-354050-kcn67stj	202	20	BAG3	BAG3	NNP
cord-354050-kcn67stj	202	21	,	,	,
cord-354050-kcn67stj	202	22	which	which	WDT
cord-354050-kcn67stj	202	23	promotes	promote	VBZ
cord-354050-kcn67stj	202	24	pro	pro	JJ
cord-354050-kcn67stj	202	25	-	-	JJ
cord-354050-kcn67stj	202	26	survival	survival	JJ
cord-354050-kcn67stj	202	27	signaling	signal	VBG
cord-354050-kcn67stj	202	28	through	through	IN
cord-354050-kcn67stj	202	29	the	the	DT
cord-354050-kcn67stj	202	30	PI3	pi3	NN
cord-354050-kcn67stj	202	31	K	K	NNP
cord-354050-kcn67stj	202	32	and	and	CC
cord-354050-kcn67stj	202	33	p38	p38	NN
cord-354050-kcn67stj	202	34	MAPK	MAPK	NNP
cord-354050-kcn67stj	202	35	pathways	pathway	NNS
cord-354050-kcn67stj	202	36	[	[	-LRB-
cord-354050-kcn67stj	202	37	79	79	CD
cord-354050-kcn67stj	202	38	]	]	-RRB-
cord-354050-kcn67stj	202	39	.	.	.
cord-354050-kcn67stj	203	1	Several	several	JJ
cord-354050-kcn67stj	203	2	reports	report	NNS
cord-354050-kcn67stj	203	3	highlighting	highlight	VBG
cord-354050-kcn67stj	203	4	IFITM	IFITM	NNP
cord-354050-kcn67stj	203	5	-	-	HYPH
cord-354050-kcn67stj	203	6	mediated	mediate	VBN
cord-354050-kcn67stj	203	7	impacts	impact	NNS
cord-354050-kcn67stj	203	8	on	on	IN
cord-354050-kcn67stj	203	9	basic	basic	JJ
cord-354050-kcn67stj	203	10	cellular	cellular	JJ
cord-354050-kcn67stj	203	11	processes	process	NNS
cord-354050-kcn67stj	203	12	provide	provide	VBP
cord-354050-kcn67stj	203	13	further	further	JJ
cord-354050-kcn67stj	203	14	opportunities	opportunity	NNS
cord-354050-kcn67stj	203	15	to	to	TO
cord-354050-kcn67stj	203	16	test	test	VB
cord-354050-kcn67stj	203	17	how	how	WRB
cord-354050-kcn67stj	203	18	these	these	DT
cord-354050-kcn67stj	203	19	proteins	protein	NNS
cord-354050-kcn67stj	203	20	inhibit	inhibit	VBP
cord-354050-kcn67stj	203	21	virus	virus	NN
cord-354050-kcn67stj	203	22	infections	infection	NNS
cord-354050-kcn67stj	203	23	.	.	.
cord-354050-kcn67stj	204	1	A	a	DT
cord-354050-kcn67stj	204	2	focus	focus	NN
cord-354050-kcn67stj	204	3	on	on	IN
cord-354050-kcn67stj	204	4	functional	functional	JJ
cord-354050-kcn67stj	204	5	roles	role	NNS
cord-354050-kcn67stj	204	6	of	of	IN
cord-354050-kcn67stj	204	7	endogenous	endogenous	JJ
cord-354050-kcn67stj	204	8	,	,	,
cord-354050-kcn67stj	204	9	rather	rather	RB
cord-354050-kcn67stj	204	10	than	than	IN
cord-354050-kcn67stj	204	11	overexpressed	overexpresse	VBN
cord-354050-kcn67stj	204	12	,	,	,
cord-354050-kcn67stj	204	13	IFITM	IFITM	NNP
cord-354050-kcn67stj	204	14	proteins	protein	NNS
cord-354050-kcn67stj	204	15	has	have	VBZ
cord-354050-kcn67stj	204	16	been	be	VBN
cord-354050-kcn67stj	204	17	crucial	crucial	JJ
cord-354050-kcn67stj	204	18	to	to	IN
cord-354050-kcn67stj	204	19	this	this	DT
cord-354050-kcn67stj	204	20	end	end	NN
cord-354050-kcn67stj	204	21	.	.	.
cord-354050-kcn67stj	205	1	A	a	DT
cord-354050-kcn67stj	205	2	prime	prime	JJ
cord-354050-kcn67stj	205	3	example	example	NN
cord-354050-kcn67stj	205	4	is	be	VBZ
cord-354050-kcn67stj	205	5	the	the	DT
cord-354050-kcn67stj	205	6	observation	observation	NN
cord-354050-kcn67stj	205	7	that	that	IN
cord-354050-kcn67stj	205	8	deletion	deletion	NN
cord-354050-kcn67stj	205	9	of	of	IN
cord-354050-kcn67stj	205	10	the	the	DT
cord-354050-kcn67stj	205	11	ifitm	ifitm	NN
cord-354050-kcn67stj	205	12	locus	locus	NN
cord-354050-kcn67stj	205	13	in	in	IN
cord-354050-kcn67stj	205	14	murine	murine	JJ
cord-354050-kcn67stj	205	15	cells	cell	NNS
cord-354050-kcn67stj	205	16	led	lead	VBD
cord-354050-kcn67stj	205	17	to	to	IN
cord-354050-kcn67stj	205	18	interruption	interruption	NN
cord-354050-kcn67stj	205	19	of	of	IN
cord-354050-kcn67stj	205	20	clathrin	clathrin	NN
cord-354050-kcn67stj	205	21	-	-	HYPH
cord-354050-kcn67stj	205	22	mediated	mediate	VBN
cord-354050-kcn67stj	205	23	endocytosis	endocytosis	NN
cord-354050-kcn67stj	205	24	and	and	CC
cord-354050-kcn67stj	205	25	loss	loss	NN
cord-354050-kcn67stj	205	26	of	of	IN
cord-354050-kcn67stj	205	27	acidity	acidity	NN
cord-354050-kcn67stj	205	28	within	within	IN
cord-354050-kcn67stj	205	29	endosomes	endosome	NNS
cord-354050-kcn67stj	205	30	,	,	,
cord-354050-kcn67stj	205	31	suggesting	suggest	VBG
cord-354050-kcn67stj	205	32	that	that	IN
cord-354050-kcn67stj	205	33	endogenous	endogenous	JJ
cord-354050-kcn67stj	205	34	IFITM	IFITM	NNP
cord-354050-kcn67stj	205	35	proteins	protein	NNS
cord-354050-kcn67stj	205	36	might	may	MD
cord-354050-kcn67stj	205	37	positively	positively	RB
cord-354050-kcn67stj	205	38	regulate	regulate	VB
cord-354050-kcn67stj	205	39	these	these	DT
cord-354050-kcn67stj	205	40	processes	process	NNS
cord-354050-kcn67stj	205	41	in	in	IN
cord-354050-kcn67stj	205	42	vivo	vivo	NN
cord-354050-kcn67stj	205	43	[	[	-LRB-
cord-354050-kcn67stj	205	44	80	80	CD
cord-354050-kcn67stj	205	45	]	]	-RRB-
cord-354050-kcn67stj	205	46	.	.	.
cord-354050-kcn67stj	206	1	This	this	DT
cord-354050-kcn67stj	206	2	possibility	possibility	NN
cord-354050-kcn67stj	206	3	is	be	VBZ
cord-354050-kcn67stj	206	4	further	far	RBR
cord-354050-kcn67stj	206	5	supported	support	VBN
cord-354050-kcn67stj	206	6	by	by	IN
cord-354050-kcn67stj	206	7	work	work	NN
cord-354050-kcn67stj	206	8	in	in	IN
cord-354050-kcn67stj	206	9	astrocytes	astrocyte	NNS
cord-354050-kcn67stj	206	10	showing	show	VBG
cord-354050-kcn67stj	206	11	that	that	IN
cord-354050-kcn67stj	206	12	knockdown	knockdown	NN
cord-354050-kcn67stj	206	13	of	of	IN
cord-354050-kcn67stj	206	14	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	206	15	inhibits	inhibit	VBZ
cord-354050-kcn67stj	206	16	clathrindependent	clathrindependent	NN
cord-354050-kcn67stj	206	17	endocytosis	endocytosis	NN
cord-354050-kcn67stj	206	18	[	[	-LRB-
cord-354050-kcn67stj	206	19	81	81	CD
cord-354050-kcn67stj	206	20	]	]	-RRB-
cord-354050-kcn67stj	206	21	.	.	.
cord-354050-kcn67stj	207	1	As	as	IN
cord-354050-kcn67stj	207	2	previously	previously	RB
cord-354050-kcn67stj	207	3	mentioned	mention	VBN
cord-354050-kcn67stj	207	4	,	,	,
cord-354050-kcn67stj	207	5	the	the	DT
cord-354050-kcn67stj	207	6	ifitm	ifitm	NN
cord-354050-kcn67stj	207	7	-	-	HYPH
cord-354050-kcn67stj	207	8	deficient	deficient	JJ
cord-354050-kcn67stj	207	9	mice	mouse	NNS
cord-354050-kcn67stj	207	10	exhibit	exhibit	VBP
cord-354050-kcn67stj	207	11	an	an	DT
cord-354050-kcn67stj	207	12	age	age	NN
cord-354050-kcn67stj	207	13	-	-	HYPH
cord-354050-kcn67stj	207	14	related	relate	VBN
cord-354050-kcn67stj	207	15	obesity	obesity	NN
cord-354050-kcn67stj	207	16	associated	associate	VBN
cord-354050-kcn67stj	207	17	with	with	IN
cord-354050-kcn67stj	207	18	defects	defect	NNS
cord-354050-kcn67stj	207	19	in	in	IN
cord-354050-kcn67stj	207	20	leptin	leptin	NN
cord-354050-kcn67stj	207	21	signaling	signaling	NN
cord-354050-kcn67stj	207	22	,	,	,
cord-354050-kcn67stj	207	23	which	which	WDT
cord-354050-kcn67stj	207	24	could	could	MD
cord-354050-kcn67stj	207	25	be	be	VB
cord-354050-kcn67stj	207	26	explained	explain	VBN
cord-354050-kcn67stj	207	27	by	by	IN
cord-354050-kcn67stj	207	28	disturbances	disturbance	NNS
cord-354050-kcn67stj	207	29	in	in	IN
cord-354050-kcn67stj	207	30	ligand	ligand	NN
cord-354050-kcn67stj	207	31	-	-	HYPH
cord-354050-kcn67stj	207	32	receptor	receptor	NN
cord-354050-kcn67stj	207	33	internalization	internalization	NN
cord-354050-kcn67stj	207	34	[	[	-LRB-
cord-354050-kcn67stj	207	35	74	74	CD
cord-354050-kcn67stj	207	36	]	]	-RRB-
cord-354050-kcn67stj	207	37	.	.	.
cord-354050-kcn67stj	208	1	Interestingly	interestingly	RB
cord-354050-kcn67stj	208	2	,	,	,
cord-354050-kcn67stj	208	3	the	the	DT
cord-354050-kcn67stj	208	4	IFITM	IFITM	NNP
cord-354050-kcn67stj	208	5	proteins	protein	NNS
cord-354050-kcn67stj	208	6	are	be	VBP
cord-354050-kcn67stj	208	7	also	also	RB
cord-354050-kcn67stj	208	8	involved	involve	VBN
cord-354050-kcn67stj	208	9	with	with	IN
cord-354050-kcn67stj	208	10	the	the	DT
cord-354050-kcn67stj	208	11	endocytosis	endocytosis	NN
cord-354050-kcn67stj	208	12	-	-	HYPH
cord-354050-kcn67stj	208	13	associated	associate	VBN
cord-354050-kcn67stj	208	14	protein	protein	NN
cord-354050-kcn67stj	208	15	caveolin-1	caveolin-1	NNP
cord-354050-kcn67stj	208	16	(	(	-LRB-
cord-354050-kcn67stj	208	17	CAV-1	CAV-1	NNP
cord-354050-kcn67stj	208	18	)	)	-RRB-
cord-354050-kcn67stj	208	19	,	,	,
cord-354050-kcn67stj	208	20	with	with	IN
cord-354050-kcn67stj	208	21	consequences	consequence	NNS
cord-354050-kcn67stj	208	22	for	for	IN
cord-354050-kcn67stj	208	23	cell	cell	NN
cord-354050-kcn67stj	208	24	signaling	signal	VBG
cord-354050-kcn67stj	208	25	events	event	NNS
cord-354050-kcn67stj	208	26	[	[	-LRB-
cord-354050-kcn67stj	208	27	82	82	CD
cord-354050-kcn67stj	208	28	,	,	,
cord-354050-kcn67stj	208	29	83	83	CD
cord-354050-kcn67stj	208	30	]	]	-RRB-
cord-354050-kcn67stj	208	31	.	.	.
cord-354050-kcn67stj	209	1	Together	together	RB
cord-354050-kcn67stj	209	2	,	,	,
cord-354050-kcn67stj	209	3	these	these	DT
cord-354050-kcn67stj	209	4	data	datum	NNS
cord-354050-kcn67stj	209	5	hint	hint	NN
cord-354050-kcn67stj	209	6	that	that	IN
cord-354050-kcn67stj	209	7	impacts	impact	NNS
cord-354050-kcn67stj	209	8	on	on	IN
cord-354050-kcn67stj	209	9	endocytic	endocytic	JJ
cord-354050-kcn67stj	209	10	trafficking	trafficking	NN
cord-354050-kcn67stj	209	11	may	may	MD
cord-354050-kcn67stj	209	12	also	also	RB
cord-354050-kcn67stj	209	13	contribute	contribute	VB
cord-354050-kcn67stj	209	14	to	to	IN
cord-354050-kcn67stj	209	15	the	the	DT
cord-354050-kcn67stj	209	16	mechanisms	mechanism	NNS
cord-354050-kcn67stj	209	17	by	by	IN
cord-354050-kcn67stj	209	18	which	which	WDT
cord-354050-kcn67stj	209	19	IFITM	IFITM	NNP
cord-354050-kcn67stj	209	20	proteins	protein	NNS
cord-354050-kcn67stj	209	21	inhibit	inhibit	VBP
cord-354050-kcn67stj	209	22	virus	virus	NN
cord-354050-kcn67stj	209	23	entry	entry	NN
cord-354050-kcn67stj	209	24	.	.	.
cord-354050-kcn67stj	210	1	While	while	IN
cord-354050-kcn67stj	210	2	the	the	DT
cord-354050-kcn67stj	210	3	antiviral	antiviral	JJ
cord-354050-kcn67stj	210	4	effects	effect	NNS
cord-354050-kcn67stj	210	5	of	of	IN
cord-354050-kcn67stj	210	6	IFITM	IFITM	NNP
cord-354050-kcn67stj	210	7	proteins	protein	NNS
cord-354050-kcn67stj	210	8	are	be	VBP
cord-354050-kcn67stj	210	9	generally	generally	RB
cord-354050-kcn67stj	210	10	assumed	assume	VBN
cord-354050-kcn67stj	210	11	to	to	TO
cord-354050-kcn67stj	210	12	manifest	manifest	VB
cord-354050-kcn67stj	210	13	at	at	IN
cord-354050-kcn67stj	210	14	the	the	DT
cord-354050-kcn67stj	210	15	stage	stage	NN
cord-354050-kcn67stj	210	16	of	of	IN
cord-354050-kcn67stj	210	17	virus	virus	NN
cord-354050-kcn67stj	210	18	-	-	HYPH
cord-354050-kcn67stj	210	19	cell	cell	NN
cord-354050-kcn67stj	210	20	fusion	fusion	NN
cord-354050-kcn67stj	210	21	,	,	,
cord-354050-kcn67stj	210	22	these	these	DT
cord-354050-kcn67stj	210	23	data	datum	NNS
cord-354050-kcn67stj	210	24	suggest	suggest	VBP
cord-354050-kcn67stj	210	25	that	that	IN
cord-354050-kcn67stj	210	26	an	an	DT
cord-354050-kcn67stj	210	27	effect	effect	NN
cord-354050-kcn67stj	210	28	on	on	IN
cord-354050-kcn67stj	210	29	virus	virus	NN
cord-354050-kcn67stj	210	30	internalization	internalization	NN
cord-354050-kcn67stj	210	31	must	must	MD
cord-354050-kcn67stj	210	32	be	be	VB
cord-354050-kcn67stj	210	33	carefully	carefully	RB
cord-354050-kcn67stj	210	34	considered	consider	VBN
cord-354050-kcn67stj	210	35	on	on	IN
cord-354050-kcn67stj	210	36	a	a	DT
cord-354050-kcn67stj	210	37	case	case	NN
cord-354050-kcn67stj	210	38	-	-	HYPH
cord-354050-kcn67stj	210	39	by	by	IN
cord-354050-kcn67stj	210	40	-	-	HYPH
cord-354050-kcn67stj	210	41	case	case	NN
cord-354050-kcn67stj	210	42	basis	basis	NN
cord-354050-kcn67stj	210	43	.	.	.
cord-354050-kcn67stj	211	1	For	for	IN
cord-354050-kcn67stj	211	2	example	example	NN
cord-354050-kcn67stj	211	3	,	,	,
cord-354050-kcn67stj	211	4	since	since	IN
cord-354050-kcn67stj	211	5	knockdown	knockdown	NN
cord-354050-kcn67stj	211	6	or	or	CC
cord-354050-kcn67stj	211	7	knockout	knockout	NN
cord-354050-kcn67stj	211	8	of	of	IN
cord-354050-kcn67stj	211	9	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	211	10	leads	lead	NNS
cord-354050-kcn67stj	211	11	to	to	IN
cord-354050-kcn67stj	211	12	decreases	decrease	NNS
cord-354050-kcn67stj	211	13	in	in	IN
cord-354050-kcn67stj	211	14	clathrin	clathrin	NN
cord-354050-kcn67stj	211	15	-	-	HYPH
cord-354050-kcn67stj	211	16	mediated	mediate	VBN
cord-354050-kcn67stj	211	17	endocytosis	endocytosis	NN
cord-354050-kcn67stj	211	18	and	and	CC
cord-354050-kcn67stj	211	19	increases	increase	NNS
cord-354050-kcn67stj	211	20	in	in	IN
cord-354050-kcn67stj	211	21	virus	virus	NN
cord-354050-kcn67stj	211	22	entry	entry	NN
cord-354050-kcn67stj	211	23	,	,	,
cord-354050-kcn67stj	211	24	it	-PRON-	PRP
cord-354050-kcn67stj	211	25	is	be	VBZ
cord-354050-kcn67stj	211	26	possible	possible	JJ
cord-354050-kcn67stj	211	27	that	that	IN
cord-354050-kcn67stj	211	28	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	211	29	promotes	promote	VBZ
cord-354050-kcn67stj	211	30	the	the	DT
cord-354050-kcn67stj	211	31	trafficking	trafficking	NN
cord-354050-kcn67stj	211	32	of	of	IN
cord-354050-kcn67stj	211	33	incoming	incoming	JJ
cord-354050-kcn67stj	211	34	virions	virion	NNS
cord-354050-kcn67stj	211	35	into	into	IN
cord-354050-kcn67stj	211	36	endocytic	endocytic	JJ
cord-354050-kcn67stj	211	37	pathways	pathway	NNS
cord-354050-kcn67stj	211	38	that	that	WDT
cord-354050-kcn67stj	211	39	are	be	VBP
cord-354050-kcn67stj	211	40	acidified	acidify	VBN
cord-354050-kcn67stj	211	41	,	,	,
cord-354050-kcn67stj	211	42	degradatory	degradatory	NNP
cord-354050-kcn67stj	211	43	and/or	and/or	CC
cord-354050-kcn67stj	211	44	otherwise	otherwise	RB
cord-354050-kcn67stj	211	45	non	non	JJ
cord-354050-kcn67stj	211	46	-	-	JJ
cord-354050-kcn67stj	211	47	productive	productive	JJ
cord-354050-kcn67stj	211	48	.	.	.
cord-354050-kcn67stj	212	1	Since	since	IN
cord-354050-kcn67stj	212	2	IFITM	IFITM	NNP
cord-354050-kcn67stj	212	3	proteins	protein	NNS
cord-354050-kcn67stj	212	4	share	share	VBP
cord-354050-kcn67stj	212	5	a	a	DT
cord-354050-kcn67stj	212	6	high	high	JJ
cord-354050-kcn67stj	212	7	degree	degree	NN
cord-354050-kcn67stj	212	8	of	of	IN
cord-354050-kcn67stj	212	9	sequence	sequence	NN
cord-354050-kcn67stj	212	10	homology	homology	NN
cord-354050-kcn67stj	212	11	(	(	-LRB-
cord-354050-kcn67stj	212	12	especially	especially	RB
cord-354050-kcn67stj	212	13	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	212	14	and	and	CC
cord-354050-kcn67stj	212	15	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	212	16	,	,	,
cord-354050-kcn67stj	212	17	which	which	WDT
cord-354050-kcn67stj	212	18	differ	differ	VBP
cord-354050-kcn67stj	212	19	by	by	IN
cord-354050-kcn67stj	212	20	only	only	RB
cord-354050-kcn67stj	212	21	13	13	CD
cord-354050-kcn67stj	212	22	amino	amino	JJ
cord-354050-kcn67stj	212	23	acids	acid	NNS
cord-354050-kcn67stj	212	24	)	)	-RRB-
cord-354050-kcn67stj	212	25	,	,	,
cord-354050-kcn67stj	212	26	future	future	JJ
cord-354050-kcn67stj	212	27	efforts	effort	NNS
cord-354050-kcn67stj	212	28	must	must	MD
cord-354050-kcn67stj	212	29	assess	assess	VB
cord-354050-kcn67stj	212	30	the	the	DT
cord-354050-kcn67stj	212	31	specific	specific	JJ
cord-354050-kcn67stj	212	32	or	or	CC
cord-354050-kcn67stj	212	33	redundant	redundant	JJ
cord-354050-kcn67stj	212	34	role	role	NN
cord-354050-kcn67stj	212	35	for	for	IN
cord-354050-kcn67stj	212	36	each	each	DT
cord-354050-kcn67stj	212	37	IFITM	IFITM	NNP
cord-354050-kcn67stj	212	38	family	family	NN
cord-354050-kcn67stj	212	39	member	member	NN
cord-354050-kcn67stj	212	40	when	when	WRB
cord-354050-kcn67stj	212	41	describing	describe	VBG
cord-354050-kcn67stj	212	42	new	new	JJ
cord-354050-kcn67stj	212	43	activities	activity	NNS
cord-354050-kcn67stj	212	44	.	.	.
cord-354050-kcn67stj	213	1	Only	only	RB
cord-354050-kcn67stj	213	2	then	then	RB
cord-354050-kcn67stj	213	3	can	can	MD
cord-354050-kcn67stj	213	4	the	the	DT
cord-354050-kcn67stj	213	5	functional	functional	JJ
cord-354050-kcn67stj	213	6	utility	utility	NN
cord-354050-kcn67stj	213	7	of	of	IN
cord-354050-kcn67stj	213	8	each	each	DT
cord-354050-kcn67stj	213	9	be	be	VB
cord-354050-kcn67stj	213	10	properly	properly	RB
cord-354050-kcn67stj	213	11	understood	understand	VBN
cord-354050-kcn67stj	213	12	,	,	,
cord-354050-kcn67stj	213	13	be	be	VB
cord-354050-kcn67stj	213	14	it	-PRON-	PRP
cord-354050-kcn67stj	213	15	during	during	IN
cord-354050-kcn67stj	213	16	virus	virus	NN
cord-354050-kcn67stj	213	17	infection	infection	NN
cord-354050-kcn67stj	213	18	or	or	CC
cord-354050-kcn67stj	213	19	basal	basal	JJ
cord-354050-kcn67stj	213	20	cellular	cellular	JJ
cord-354050-kcn67stj	213	21	homeostasis	homeostasis	NN
cord-354050-kcn67stj	213	22	.	.	.
cord-354050-kcn67stj	214	1	Furthermore	furthermore	RB
cord-354050-kcn67stj	214	2	,	,	,
cord-354050-kcn67stj	214	3	it	-PRON-	PRP
cord-354050-kcn67stj	214	4	is	be	VBZ
cord-354050-kcn67stj	214	5	important	important	JJ
cord-354050-kcn67stj	214	6	to	to	TO
cord-354050-kcn67stj	214	7	test	test	VB
cord-354050-kcn67stj	214	8	whether	whether	IN
cord-354050-kcn67stj	214	9	interferon	interferon	NN
cord-354050-kcn67stj	214	10	signaling	signaling	NN
cord-354050-kcn67stj	214	11	serves	serve	VBZ
cord-354050-kcn67stj	214	12	as	as	IN
cord-354050-kcn67stj	214	13	a	a	DT
cord-354050-kcn67stj	214	14	'	'	``
cord-354050-kcn67stj	214	15	switch	switch	NN
cord-354050-kcn67stj	214	16	'	'	''
cord-354050-kcn67stj	214	17	to	to	TO
cord-354050-kcn67stj	214	18	promote	promote	VB
cord-354050-kcn67stj	214	19	antiviral	antiviral	JJ
cord-354050-kcn67stj	214	20	functions	function	NNS
cord-354050-kcn67stj	214	21	over	over	IN
cord-354050-kcn67stj	214	22	housekeeping	housekeeping	NN
cord-354050-kcn67stj	214	23	ones	one	NNS
cord-354050-kcn67stj	214	24	.	.	.
cord-354050-kcn67stj	215	1	We	-PRON-	PRP
cord-354050-kcn67stj	215	2	expect	expect	VBP
cord-354050-kcn67stj	215	3	that	that	IN
cord-354050-kcn67stj	215	4	boosting	boost	VBG
cord-354050-kcn67stj	215	5	efforts	effort	NNS
cord-354050-kcn67stj	215	6	towards	towards	IN
cord-354050-kcn67stj	215	7	understanding	understand	VBG
cord-354050-kcn67stj	215	8	the	the	DT
cord-354050-kcn67stj	215	9	host	host	NN
cord-354050-kcn67stj	215	10	factors	factor	NNS
cord-354050-kcn67stj	215	11	interacting	interact	VBG
cord-354050-kcn67stj	215	12	with	with	IN
cord-354050-kcn67stj	215	13	IFITM	IFITM	NNP
cord-354050-kcn67stj	215	14	proteins	protein	NNS
cord-354050-kcn67stj	215	15	will	will	MD
cord-354050-kcn67stj	215	16	expose	expose	VB
cord-354050-kcn67stj	215	17	novel	novel	JJ
cord-354050-kcn67stj	215	18	purposes	purpose	NNS
cord-354050-kcn67stj	215	19	in	in	IN
cord-354050-kcn67stj	215	20	cells	cell	NNS
cord-354050-kcn67stj	215	21	,	,	,
cord-354050-kcn67stj	215	22	which	which	WDT
cord-354050-kcn67stj	215	23	may	may	MD
cord-354050-kcn67stj	215	24	,	,	,
cord-354050-kcn67stj	215	25	in	in	IN
cord-354050-kcn67stj	215	26	turn	turn	NN
cord-354050-kcn67stj	215	27	,	,	,
cord-354050-kcn67stj	215	28	reveal	reveal	VB
cord-354050-kcn67stj	215	29	additional	additional	JJ
cord-354050-kcn67stj	215	30	ways	way	NNS
cord-354050-kcn67stj	215	31	by	by	IN
cord-354050-kcn67stj	215	32	which	which	WDT
cord-354050-kcn67stj	215	33	these	these	DT
cord-354050-kcn67stj	215	34	proteins	protein	NNS
cord-354050-kcn67stj	215	35	interfere	interfere	VBP
cord-354050-kcn67stj	215	36	with	with	IN
cord-354050-kcn67stj	215	37	virus	virus	NN
cord-354050-kcn67stj	215	38	infections	infection	NNS
cord-354050-kcn67stj	215	39	.	.	.
cord-354050-kcn67stj	216	1	Cell	cell	NN
cord-354050-kcn67stj	216	2	-	-	HYPH
cord-354050-kcn67stj	216	3	based	base	VBN
cord-354050-kcn67stj	216	4	experiments	experiment	NNS
cord-354050-kcn67stj	216	5	have	have	VBP
cord-354050-kcn67stj	216	6	identified	identify	VBN
cord-354050-kcn67stj	216	7	many	many	JJ
cord-354050-kcn67stj	216	8	binding	bind	VBG
cord-354050-kcn67stj	216	9	partners	partner	NNS
cord-354050-kcn67stj	216	10	of	of	IN
cord-354050-kcn67stj	216	11	IFITM	IFITM	NNP
cord-354050-kcn67stj	216	12	proteins	protein	NNS
cord-354050-kcn67stj	216	13	,	,	,
cord-354050-kcn67stj	216	14	but	but	CC
cord-354050-kcn67stj	216	15	in	in	IN
cord-354050-kcn67stj	216	16	most	most	JJS
cord-354050-kcn67stj	216	17	cases	case	NNS
cord-354050-kcn67stj	216	18	,	,	,
cord-354050-kcn67stj	216	19	it	-PRON-	PRP
cord-354050-kcn67stj	216	20	is	be	VBZ
cord-354050-kcn67stj	216	21	unclear	unclear	JJ
cord-354050-kcn67stj	216	22	whether	whether	IN
cord-354050-kcn67stj	216	23	Cytokine	cytokine	JJ
cord-354050-kcn67stj	216	24	regulation	regulation	NN
cord-354050-kcn67stj	216	25	;	;	:
cord-354050-kcn67stj	216	26	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	216	27	is	be	VBZ
cord-354050-kcn67stj	216	28	a	a	DT
cord-354050-kcn67stj	216	29	negative	negative	JJ
cord-354050-kcn67stj	216	30	regulator	regulator	NN
cord-354050-kcn67stj	216	31	of	of	IN
cord-354050-kcn67stj	216	32	the	the	DT
cord-354050-kcn67stj	216	33	interferon	interferon	NN
cord-354050-kcn67stj	216	34	response	response	NN
cord-354050-kcn67stj	216	35	because	because	IN
cord-354050-kcn67stj	216	36	it	-PRON-	PRP
cord-354050-kcn67stj	216	37	accelerates	accelerate	VBZ
cord-354050-kcn67stj	216	38	the	the	DT
cord-354050-kcn67stj	216	39	turnover	turnover	NN
cord-354050-kcn67stj	216	40	of	of	IN
cord-354050-kcn67stj	216	41	IRF3	IRF3	NNP
cord-354050-kcn67stj	216	42	in	in	IN
cord-354050-kcn67stj	216	43	autophagosomes	autophagosomes	NNP
cord-354050-kcn67stj	216	44	.	.	.
cord-354050-kcn67stj	217	1	It	-PRON-	PRP
cord-354050-kcn67stj	217	2	also	also	RB
cord-354050-kcn67stj	217	3	suppresses	suppress	VBZ
cord-354050-kcn67stj	217	4	the	the	DT
cord-354050-kcn67stj	217	5	production	production	NN
cord-354050-kcn67stj	217	6	of	of	IN
cord-354050-kcn67stj	217	7	IL-6	IL-6	NNP
cord-354050-kcn67stj	217	8	,	,	,
cord-354050-kcn67stj	217	9	a	a	DT
cord-354050-kcn67stj	217	10	pro	pro	JJ
cord-354050-kcn67stj	217	11	-	-	JJ
cord-354050-kcn67stj	217	12	inflammatory	inflammatory	JJ
cord-354050-kcn67stj	217	13	cytokine	cytokine	NN
cord-354050-kcn67stj	217	14	which	which	WDT
cord-354050-kcn67stj	217	15	,	,	,
cord-354050-kcn67stj	217	16	itself	-PRON-	PRP
cord-354050-kcn67stj	217	17	,	,	,
cord-354050-kcn67stj	217	18	can	can	MD
cord-354050-kcn67stj	217	19	also	also	RB
cord-354050-kcn67stj	217	20	induce	induce	VB
cord-354050-kcn67stj	217	21	the	the	DT
cord-354050-kcn67stj	217	22	expression	expression	NN
cord-354050-kcn67stj	217	23	of	of	IN
cord-354050-kcn67stj	217	24	IFITM	IFITM	NNP
cord-354050-kcn67stj	217	25	genes	gene	NNS
cord-354050-kcn67stj	217	26	.	.	.
cord-354050-kcn67stj	218	1	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	218	2	,	,	,
cord-354050-kcn67stj	218	3	in	in	IN
cord-354050-kcn67stj	218	4	contrast	contrast	NN
cord-354050-kcn67stj	218	5	,	,	,
cord-354050-kcn67stj	218	6	promotes	promote	VBZ
cord-354050-kcn67stj	218	7	the	the	DT
cord-354050-kcn67stj	218	8	upregulation	upregulation	NN
cord-354050-kcn67stj	218	9	of	of	IN
cord-354050-kcn67stj	218	10	IL-6	IL-6	NNP
cord-354050-kcn67stj	218	11	by	by	IN
cord-354050-kcn67stj	218	12	acting	act	VBG
cord-354050-kcn67stj	218	13	as	as	IN
cord-354050-kcn67stj	218	14	a	a	DT
cord-354050-kcn67stj	218	15	cell	cell	NN
cord-354050-kcn67stj	218	16	surface	surface	NN
cord-354050-kcn67stj	218	17	receptor	receptor	NN
cord-354050-kcn67stj	218	18	for	for	IN
cord-354050-kcn67stj	218	19	secreted	secrete	VBN
cord-354050-kcn67stj	218	20	BAG3	BAG3	NNP
cord-354050-kcn67stj	218	21	.	.	.
cord-354050-kcn67stj	219	1	As	as	IN
cord-354050-kcn67stj	219	2	BAG3	BAG3	NNP
cord-354050-kcn67stj	219	3	is	be	VBZ
cord-354050-kcn67stj	219	4	also	also	RB
cord-354050-kcn67stj	219	5	a	a	DT
cord-354050-kcn67stj	219	6	well	well	RB
cord-354050-kcn67stj	219	7	-	-	HYPH
cord-354050-kcn67stj	219	8	characterized	characterize	VBN
cord-354050-kcn67stj	219	9	chaperone	chaperone	NN
cord-354050-kcn67stj	219	10	for	for	IN
cord-354050-kcn67stj	219	11	selective	selective	JJ
cord-354050-kcn67stj	219	12	autophagy	autophagy	NN
cord-354050-kcn67stj	219	13	,	,	,
cord-354050-kcn67stj	219	14	it	-PRON-	PRP
cord-354050-kcn67stj	219	15	will	will	MD
cord-354050-kcn67stj	219	16	be	be	VB
cord-354050-kcn67stj	219	17	of	of	IN
cord-354050-kcn67stj	219	18	interest	interest	NN
cord-354050-kcn67stj	219	19	to	to	TO
cord-354050-kcn67stj	219	20	determine	determine	VB
cord-354050-kcn67stj	219	21	if	if	IN
cord-354050-kcn67stj	219	22	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	219	23	also	also	RB
cord-354050-kcn67stj	219	24	participates	participate	VBZ
cord-354050-kcn67stj	219	25	with	with	IN
cord-354050-kcn67stj	219	26	BAG3	BAG3	NNP
cord-354050-kcn67stj	219	27	in	in	IN
cord-354050-kcn67stj	219	28	autophagy	autophagy	NN
cord-354050-kcn67stj	219	29	-	-	HYPH
cord-354050-kcn67stj	219	30	related	relate	VBN
cord-354050-kcn67stj	219	31	processes	process	NNS
cord-354050-kcn67stj	219	32	.	.	.
cord-354050-kcn67stj	220	1	Cell	cell	NN
cord-354050-kcn67stj	220	2	migration	migration	NN
cord-354050-kcn67stj	220	3	and	and	CC
cord-354050-kcn67stj	220	4	invasion	invasion	NN
cord-354050-kcn67stj	220	5	;	;	:
cord-354050-kcn67stj	220	6	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	220	7	is	be	VBZ
cord-354050-kcn67stj	220	8	a	a	DT
cord-354050-kcn67stj	220	9	central	central	JJ
cord-354050-kcn67stj	220	10	component	component	NN
cord-354050-kcn67stj	220	11	of	of	IN
cord-354050-kcn67stj	220	12	a	a	DT
cord-354050-kcn67stj	220	13	multi	multi	JJ
cord-354050-kcn67stj	220	14	-	-	JJ
cord-354050-kcn67stj	220	15	protein	protein	JJ
cord-354050-kcn67stj	220	16	interaction	interaction	NN
cord-354050-kcn67stj	220	17	involving	involve	VBG
cord-354050-kcn67stj	220	18	Src	Src	NNP
cord-354050-kcn67stj	220	19	,	,	,
cord-354050-kcn67stj	220	20	FAK	FAK	NNP
cord-354050-kcn67stj	220	21	,	,	,
cord-354050-kcn67stj	220	22	and	and	CC
cord-354050-kcn67stj	220	23	Ambra1	Ambra1	NNP
cord-354050-kcn67stj	220	24	,	,	,
cord-354050-kcn67stj	220	25	which	which	WDT
cord-354050-kcn67stj	220	26	is	be	VBZ
cord-354050-kcn67stj	220	27	important	important	JJ
cord-354050-kcn67stj	220	28	for	for	IN
cord-354050-kcn67stj	220	29	regulating	regulate	VBG
cord-354050-kcn67stj	220	30	cell	cell	NN
cord-354050-kcn67stj	220	31	adhesion	adhesion	NN
cord-354050-kcn67stj	220	32	and	and	CC
cord-354050-kcn67stj	220	33	movement	movement	NN
cord-354050-kcn67stj	220	34	.	.	.
cord-354050-kcn67stj	221	1	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	221	2	assists	assist	NNS
cord-354050-kcn67stj	221	3	in	in	IN
cord-354050-kcn67stj	221	4	the	the	DT
cord-354050-kcn67stj	221	5	subcellular	subcellular	JJ
cord-354050-kcn67stj	221	6	trafficking	trafficking	NN
cord-354050-kcn67stj	221	7	of	of	IN
cord-354050-kcn67stj	221	8	Src	Src	NNP
cord-354050-kcn67stj	221	9	between	between	IN
cord-354050-kcn67stj	221	10	focal	focal	JJ
cord-354050-kcn67stj	221	11	adhesion	adhesion	NN
cord-354050-kcn67stj	221	12	points	point	NNS
cord-354050-kcn67stj	221	13	and	and	CC
cord-354050-kcn67stj	221	14	autophagosomes	autophagosome	NNS
cord-354050-kcn67stj	221	15	.	.	.
cord-354050-kcn67stj	222	1	Cell	cell	NN
cord-354050-kcn67stj	222	2	growth	growth	NN
cord-354050-kcn67stj	222	3	,	,	,
cord-354050-kcn67stj	222	4	proliferation	proliferation	NN
cord-354050-kcn67stj	222	5	,	,	,
cord-354050-kcn67stj	222	6	and	and	CC
cord-354050-kcn67stj	222	7	cell	cell	NN
cord-354050-kcn67stj	222	8	cycle	cycle	NN
cord-354050-kcn67stj	222	9	regulation	regulation	NN
cord-354050-kcn67stj	223	1	;	;	:
cord-354050-kcn67stj	223	2	Interferon	interferon	NN
cord-354050-kcn67stj	223	3	signaling	signaling	NN
cord-354050-kcn67stj	223	4	is	be	VBZ
cord-354050-kcn67stj	223	5	known	know	VBN
cord-354050-kcn67stj	223	6	to	to	TO
cord-354050-kcn67stj	223	7	negatively	negatively	RB
cord-354050-kcn67stj	223	8	regulate	regulate	VB
cord-354050-kcn67stj	223	9	cell	cell	NN
cord-354050-kcn67stj	223	10	division	division	NN
cord-354050-kcn67stj	223	11	and	and	CC
cord-354050-kcn67stj	223	12	growth	growth	NN
cord-354050-kcn67stj	223	13	via	via	IN
cord-354050-kcn67stj	223	14	STAT	stat	NN
cord-354050-kcn67stj	223	15	signaling	signal	VBG
cord-354050-kcn67stj	223	16	,	,	,
cord-354050-kcn67stj	223	17	with	with	IN
cord-354050-kcn67stj	223	18	IFITM	IFITM	NNP
cord-354050-kcn67stj	223	19	proteins	protein	NNS
cord-354050-kcn67stj	223	20	serving	serve	VBG
cord-354050-kcn67stj	223	21	as	as	IN
cord-354050-kcn67stj	223	22	downstream	downstream	JJ
cord-354050-kcn67stj	223	23	effectors	effector	NNS
cord-354050-kcn67stj	223	24	.	.	.
cord-354050-kcn67stj	224	1	IFITM1	IFITM1	NNP
cord-354050-kcn67stj	224	2	interacts	interact	VBZ
cord-354050-kcn67stj	224	3	with	with	IN
cord-354050-kcn67stj	224	4	caveolin-1	caveolin-1	NNP
cord-354050-kcn67stj	224	5	(	(	-LRB-
cord-354050-kcn67stj	224	6	CAV-1	CAV-1	NNP
cord-354050-kcn67stj	224	7	)	)	-RRB-
cord-354050-kcn67stj	224	8	to	to	TO
cord-354050-kcn67stj	224	9	inhibit	inhibit	VB
cord-354050-kcn67stj	224	10	ERK	ERK	NNP
cord-354050-kcn67stj	224	11	/	/	SYM
cord-354050-kcn67stj	224	12	MAPK	MAPK	NNP
cord-354050-kcn67stj	224	13	signaling	signal	VBG
cord-354050-kcn67stj	224	14	,	,	,
cord-354050-kcn67stj	224	15	a	a	DT
cord-354050-kcn67stj	224	16	pathway	pathway	NN
cord-354050-kcn67stj	224	17	which	which	WDT
cord-354050-kcn67stj	224	18	stimulates	stimulate	VBZ
cord-354050-kcn67stj	224	19	cell	cell	NN
cord-354050-kcn67stj	224	20	proliferation	proliferation	NN
cord-354050-kcn67stj	224	21	when	when	WRB
cord-354050-kcn67stj	224	22	active	active	JJ
cord-354050-kcn67stj	224	23	.	.	.
cord-354050-kcn67stj	225	1	IFITM1	IFITM1	NNP
cord-354050-kcn67stj	225	2	also	also	RB
cord-354050-kcn67stj	225	3	stabilizes	stabilize	VBZ
cord-354050-kcn67stj	225	4	p53	p53	NN
cord-354050-kcn67stj	225	5	,	,	,
cord-354050-kcn67stj	225	6	a	a	DT
cord-354050-kcn67stj	225	7	tumor	tumor	NN
cord-354050-kcn67stj	225	8	suppressor	suppressor	NN
cord-354050-kcn67stj	225	9	with	with	IN
cord-354050-kcn67stj	225	10	anti	anti	JJ
cord-354050-kcn67stj	225	11	-	-	JJ
cord-354050-kcn67stj	225	12	proliferative	proliferative	JJ
cord-354050-kcn67stj	225	13	functions	function	NNS
cord-354050-kcn67stj	225	14	these	these	DT
cord-354050-kcn67stj	225	15	interactions	interaction	NNS
cord-354050-kcn67stj	225	16	are	be	VBP
cord-354050-kcn67stj	225	17	direct	direct	JJ
cord-354050-kcn67stj	225	18	or	or	CC
cord-354050-kcn67stj	225	19	specific	specific	JJ
cord-354050-kcn67stj	225	20	.	.	.
cord-354050-kcn67stj	226	1	Interrogation	interrogation	NN
cord-354050-kcn67stj	226	2	of	of	IN
cord-354050-kcn67stj	226	3	potential	potential	JJ
cord-354050-kcn67stj	226	4	interactors	interactor	NNS
cord-354050-kcn67stj	226	5	in	in	IN
cord-354050-kcn67stj	226	6	transgenic	transgenic	JJ
cord-354050-kcn67stj	226	7	mice	mouse	NNS
cord-354050-kcn67stj	226	8	will	will	MD
cord-354050-kcn67stj	226	9	help	help	VB
cord-354050-kcn67stj	226	10	clarify	clarify	VB
cord-354050-kcn67stj	226	11	their	-PRON-	PRP$
cord-354050-kcn67stj	226	12	precise	precise	JJ
cord-354050-kcn67stj	226	13	role	role	NN
cord-354050-kcn67stj	226	14	and	and	CC
cord-354050-kcn67stj	226	15	enable	enable	VB
cord-354050-kcn67stj	226	16	prioritization	prioritization	NN
cord-354050-kcn67stj	226	17	of	of	IN
cord-354050-kcn67stj	226	18	different	different	JJ
cord-354050-kcn67stj	226	19	hypotheses	hypothesis	NNS
cord-354050-kcn67stj	226	20	.	.	.
cord-354050-kcn67stj	227	1	In	in	IN
cord-354050-kcn67stj	227	2	general	general	JJ
cord-354050-kcn67stj	227	3	,	,	,
cord-354050-kcn67stj	227	4	increased	increase	VBN
cord-354050-kcn67stj	227	5	experimental	experimental	JJ
cord-354050-kcn67stj	227	6	crosstalk	crosstalk	NN
cord-354050-kcn67stj	227	7	between	between	IN
cord-354050-kcn67stj	227	8	virology	virology	NN
cord-354050-kcn67stj	227	9	and	and	CC
cord-354050-kcn67stj	227	10	cell	cell	NN
cord-354050-kcn67stj	227	11	biology	biology	NN
cord-354050-kcn67stj	227	12	will	will	MD
cord-354050-kcn67stj	227	13	provide	provide	VB
cord-354050-kcn67stj	227	14	much	much	JJ
cord-354050-kcn67stj	227	15	needed	need	VBN
cord-354050-kcn67stj	227	16	opportunities	opportunity	NNS
cord-354050-kcn67stj	227	17	for	for	IN
cord-354050-kcn67stj	227	18	discovery	discovery	NN
cord-354050-kcn67stj	227	19	and	and	CC
cord-354050-kcn67stj	227	20	will	will	MD
cord-354050-kcn67stj	227	21	facilitate	facilitate	VB
cord-354050-kcn67stj	227	22	the	the	DT
cord-354050-kcn67stj	227	23	development	development	NN
cord-354050-kcn67stj	227	24	of	of	IN
cord-354050-kcn67stj	227	25	host	host	NN
cord-354050-kcn67stj	227	26	-	-	HYPH
cord-354050-kcn67stj	227	27	directed	direct	VBN
cord-354050-kcn67stj	227	28	therapies	therapy	NNS
cord-354050-kcn67stj	227	29	targeting	target	VBG
cord-354050-kcn67stj	227	30	IFITM	IFITM	NNP
cord-354050-kcn67stj	227	31	proteins	protein	NNS
cord-354050-kcn67stj	227	32	in	in	IN
cord-354050-kcn67stj	227	33	the	the	DT
cord-354050-kcn67stj	227	34	setting	setting	NN
cord-354050-kcn67stj	227	35	of	of	IN
cord-354050-kcn67stj	227	36	infection	infection	NN
cord-354050-kcn67stj	227	37	and	and	CC
cord-354050-kcn67stj	227	38	cancer	cancer	NN
cord-354050-kcn67stj	227	39	.	.	.
cord-354050-kcn67stj	228	1	The	the	DT
cord-354050-kcn67stj	228	2	broad	broad	JJ
cord-354050-kcn67stj	228	3	-	-	HYPH
cord-354050-kcn67stj	228	4	spectrum	spectrum	NN
cord-354050-kcn67stj	228	5	antiviral	antiviral	JJ
cord-354050-kcn67stj	228	6	functions	function	NNS
cord-354050-kcn67stj	228	7	of	of	IN
cord-354050-kcn67stj	228	8	IFIT	IFIT	NNP
cord-354050-kcn67stj	228	9	and	and	CC
cord-354050-kcn67stj	228	10	IFITM	IFITM	NNP
cord-354050-kcn67stj	228	11	proteins	protein	NNS
cord-354050-kcn67stj	229	1	The	the	DT
cord-354050-kcn67stj	229	2	dispanins	dispanin	NNS
cord-354050-kcn67stj	229	3	:	:	:
cord-354050-kcn67stj	229	4	a	a	DT
cord-354050-kcn67stj	229	5	novel	novel	JJ
cord-354050-kcn67stj	229	6	gene	gene	NN
cord-354050-kcn67stj	229	7	family	family	NN
cord-354050-kcn67stj	229	8	of	of	IN
cord-354050-kcn67stj	229	9	ancient	ancient	JJ
cord-354050-kcn67stj	229	10	origin	origin	NN
cord-354050-kcn67stj	229	11	that	that	WDT
cord-354050-kcn67stj	229	12	contains	contain	VBZ
cord-354050-kcn67stj	229	13	14	14	CD
cord-354050-kcn67stj	229	14	human	human	JJ
cord-354050-kcn67stj	229	15	members	member	NNS
cord-354050-kcn67stj	229	16	Evolution	Evolution	NNP
cord-354050-kcn67stj	229	17	of	of	IN
cord-354050-kcn67stj	229	18	vertebrate	vertebrate	JJ
cord-354050-kcn67stj	229	19	interferon	interferon	NN
cord-354050-kcn67stj	229	20	inducible	inducible	JJ
cord-354050-kcn67stj	229	21	transmembrane	transmembrane	NN
cord-354050-kcn67stj	229	22	proteins	protein	NNS
cord-354050-kcn67stj	229	23	Evolutionary	evolutionary	JJ
cord-354050-kcn67stj	229	24	dynamics	dynamic	NNS
cord-354050-kcn67stj	229	25	of	of	IN
cord-354050-kcn67stj	229	26	the	the	DT
cord-354050-kcn67stj	229	27	interferon	interferon	NN
cord-354050-kcn67stj	229	28	-	-	HYPH
cord-354050-kcn67stj	229	29	induced	induce	VBN
cord-354050-kcn67stj	229	30	transmembrane	transmembrane	NN
cord-354050-kcn67stj	229	31	gene	gene	NN
cord-354050-kcn67stj	229	32	family	family	NN
cord-354050-kcn67stj	229	33	in	in	IN
cord-354050-kcn67stj	229	34	vertebrates	vertebrate	NNS
cord-354050-kcn67stj	230	1	Natural	natural	JJ
cord-354050-kcn67stj	230	2	mutations	mutation	NNS
cord-354050-kcn67stj	230	3	in	in	IN
cord-354050-kcn67stj	230	4	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	230	5	modulate	modulate	VB
cord-354050-kcn67stj	230	6	post	post	JJ
cord-354050-kcn67stj	230	7	-	-	JJ
cord-354050-kcn67stj	230	8	translational	translational	JJ
cord-354050-kcn67stj	230	9	regulation	regulation	NN
cord-354050-kcn67stj	230	10	and	and	CC
cord-354050-kcn67stj	230	11	toggle	toggle	NN
cord-354050-kcn67stj	230	12	antiviral	antiviral	JJ
cord-354050-kcn67stj	230	13	specificity	specificity	NN
cord-354050-kcn67stj	231	1	IFITMs	ifitm	NNS
cord-354050-kcn67stj	231	2	restrict	restrict	VBP
cord-354050-kcn67stj	231	3	the	the	DT
cord-354050-kcn67stj	231	4	replication	replication	NN
cord-354050-kcn67stj	231	5	of	of	IN
cord-354050-kcn67stj	231	6	multiple	multiple	JJ
cord-354050-kcn67stj	231	7	pathogenic	pathogenic	JJ
cord-354050-kcn67stj	231	8	viruses	virus	NNS
cord-354050-kcn67stj	231	9	IFITM	IFITM	NNP
cord-354050-kcn67stj	231	10	proteins	protein	NNS
cord-354050-kcn67stj	231	11	-	-	:
cord-354050-kcn67stj	231	12	cellular	cellular	JJ
cord-354050-kcn67stj	231	13	inhibitors	inhibitor	NNS
cord-354050-kcn67stj	231	14	of	of	IN
cord-354050-kcn67stj	231	15	viral	viral	JJ
cord-354050-kcn67stj	231	16	entry	entry	NN
cord-354050-kcn67stj	232	1	The	the	DT
cord-354050-kcn67stj	232	2	IFITM	IFITM	NNP
cord-354050-kcn67stj	232	3	proteins	protein	NNS
cord-354050-kcn67stj	232	4	mediate	mediate	VBP
cord-354050-kcn67stj	232	5	cellular	cellular	JJ
cord-354050-kcn67stj	232	6	resistance	resistance	NN
cord-354050-kcn67stj	232	7	to	to	TO
cord-354050-kcn67stj	232	8	influenza	influenza	VB
cord-354050-kcn67stj	232	9	A	a	DT
cord-354050-kcn67stj	232	10	H1N1	H1N1	NNP
cord-354050-kcn67stj	232	11	Virus	Virus	NNP
cord-354050-kcn67stj	232	12	,	,	,
cord-354050-kcn67stj	232	13	West	West	NNP
cord-354050-kcn67stj	232	14	Nile	Nile	NNP
cord-354050-kcn67stj	232	15	virus	virus	NN
cord-354050-kcn67stj	232	16	,	,	,
cord-354050-kcn67stj	232	17	and	and	CC
cord-354050-kcn67stj	232	18	dengue	dengue	NN
cord-354050-kcn67stj	232	19	virus	virus	NN
cord-354050-kcn67stj	232	20	IFITM3	IFITM3	''
cord-354050-kcn67stj	233	1	inhibits	inhibit	VBZ
cord-354050-kcn67stj	233	2	influenza	influenza	NN
cord-354050-kcn67stj	233	3	A	a	DT
cord-354050-kcn67stj	233	4	virus	virus	NN
cord-354050-kcn67stj	233	5	infection	infection	NN
cord-354050-kcn67stj	233	6	by	by	IN
cord-354050-kcn67stj	233	7	preventing	prevent	VBG
cord-354050-kcn67stj	233	8	cytosolic	cytosolic	JJ
cord-354050-kcn67stj	233	9	entry	entry	NN
cord-354050-kcn67stj	234	1	Distinct	distinct	JJ
cord-354050-kcn67stj	234	2	patterns	pattern	NNS
cord-354050-kcn67stj	234	3	of	of	IN
cord-354050-kcn67stj	234	4	IFITM	ifitm	NN
cord-354050-kcn67stj	234	5	-	-	HYPH
cord-354050-kcn67stj	234	6	mediated	mediate	VBN
cord-354050-kcn67stj	234	7	restriction	restriction	NN
cord-354050-kcn67stj	234	8	of	of	IN
cord-354050-kcn67stj	234	9	filoviruses	filovirus	NNS
cord-354050-kcn67stj	234	10	,	,	,
cord-354050-kcn67stj	234	11	SARS	SARS	NNP
cord-354050-kcn67stj	234	12	coronavirus	coronavirus	NN
cord-354050-kcn67stj	234	13	,	,	,
cord-354050-kcn67stj	234	14	and	and	CC
cord-354050-kcn67stj	234	15	influenza	influenza	NN
cord-354050-kcn67stj	234	16	A	a	DT
cord-354050-kcn67stj	234	17	virus	virus	NN
cord-354050-kcn67stj	234	18	Regulation	regulation	NN
cord-354050-kcn67stj	234	19	of	of	IN
cord-354050-kcn67stj	234	20	the	the	DT
cord-354050-kcn67stj	234	21	trafficking	trafficking	NN
cord-354050-kcn67stj	234	22	and	and	CC
cord-354050-kcn67stj	234	23	antiviral	antiviral	JJ
cord-354050-kcn67stj	234	24	activity	activity	NN
cord-354050-kcn67stj	234	25	of	of	IN
cord-354050-kcn67stj	234	26	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	234	27	by	by	IN
cord-354050-kcn67stj	234	28	post	post	JJ
cord-354050-kcn67stj	234	29	-	-	JJ
cord-354050-kcn67stj	234	30	translational	translational	JJ
cord-354050-kcn67stj	234	31	modifications	modification	NNS
cord-354050-kcn67stj	235	1	Combined	combined	JJ
cord-354050-kcn67stj	235	2	approaches	approach	NNS
cord-354050-kcn67stj	235	3	of	of	IN
cord-354050-kcn67stj	235	4	EPR	EPR	NNP
cord-354050-kcn67stj	235	5	and	and	CC
cord-354050-kcn67stj	235	6	NMR	NMR	NNP
cord-354050-kcn67stj	235	7	illustrate	illustrate	VBP
cord-354050-kcn67stj	235	8	only	only	RB
cord-354050-kcn67stj	235	9	one	one	CD
cord-354050-kcn67stj	235	10	transmembrane	transmembrane	NN
cord-354050-kcn67stj	235	11	helix	helix	NN
cord-354050-kcn67stj	235	12	in	in	IN
cord-354050-kcn67stj	235	13	the	the	DT
cord-354050-kcn67stj	235	14	human	human	NN
cord-354050-kcn67stj	236	1	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	237	1	Interferon	interferon	NN
cord-354050-kcn67stj	237	2	-	-	HYPH
cord-354050-kcn67stj	237	3	induced	induce	VBN
cord-354050-kcn67stj	237	4	transmembrane	transmembrane	NN
cord-354050-kcn67stj	237	5	protein	protein	NN
cord-354050-kcn67stj	237	6	3	3	CD
cord-354050-kcn67stj	237	7	is	be	VBZ
cord-354050-kcn67stj	237	8	a	a	DT
cord-354050-kcn67stj	237	9	type	type	NN
cord-354050-kcn67stj	237	10	II	II	NNP
cord-354050-kcn67stj	237	11	transmembrane	transmembrane	NN
cord-354050-kcn67stj	237	12	protein	protein	NN
cord-354050-kcn67stj	237	13	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	238	1	requires	require	VBZ
cord-354050-kcn67stj	238	2	an	an	DT
cord-354050-kcn67stj	238	3	amphipathic	amphipathic	JJ
cord-354050-kcn67stj	238	4	helix	helix	NN
cord-354050-kcn67stj	238	5	for	for	IN
cord-354050-kcn67stj	238	6	antiviral	antiviral	JJ
cord-354050-kcn67stj	238	7	activity	activity	NN
cord-354050-kcn67stj	239	1	Palmitoylome	palmitoylome	NN
cord-354050-kcn67stj	239	2	profiling	profiling	NN
cord-354050-kcn67stj	239	3	reveals	reveal	VBZ
cord-354050-kcn67stj	239	4	S	s	NN
cord-354050-kcn67stj	239	5	-	-	HYPH
cord-354050-kcn67stj	239	6	palmitoylation	palmitoylation	NN
cord-354050-kcn67stj	239	7	-	-	HYPH
cord-354050-kcn67stj	239	8	dependent	dependent	JJ
cord-354050-kcn67stj	239	9	antiviral	antiviral	JJ
cord-354050-kcn67stj	239	10	activity	activity	NN
cord-354050-kcn67stj	239	11	of	of	IN
cord-354050-kcn67stj	239	12	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	240	1	The	the	DT
cord-354050-kcn67stj	240	2	palmitoyltransferase	palmitoyltransferase	NN
cord-354050-kcn67stj	240	3	ZDHHC20	ZDHHC20	NNP
cord-354050-kcn67stj	240	4	enhances	enhance	VBZ
cord-354050-kcn67stj	240	5	interferoninduced	interferoninduced	JJ
cord-354050-kcn67stj	240	6	transmembrane	transmembrane	NNP
cord-354050-kcn67stj	240	7	protein	protein	NN
cord-354050-kcn67stj	240	8	3	3	CD
cord-354050-kcn67stj	240	9	(	(	-LRB-
cord-354050-kcn67stj	240	10	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	240	11	)	)	-RRB-
cord-354050-kcn67stj	240	12	palmitoylation	palmitoylation	NN
cord-354050-kcn67stj	240	13	and	and	CC
cord-354050-kcn67stj	240	14	antiviral	antiviral	JJ
cord-354050-kcn67stj	240	15	activity	activity	NN
cord-354050-kcn67stj	240	16	Phosphorylation	Phosphorylation	NNP
cord-354050-kcn67stj	240	17	of	of	IN
cord-354050-kcn67stj	240	18	the	the	DT
cord-354050-kcn67stj	240	19	antiviral	antiviral	JJ
cord-354050-kcn67stj	240	20	protein	protein	NN
cord-354050-kcn67stj	241	1	interferon	interferon	NN
cord-354050-kcn67stj	241	2	-	-	HYPH
cord-354050-kcn67stj	241	3	inducible	inducible	JJ
cord-354050-kcn67stj	241	4	transmembrane	transmembrane	NN
cord-354050-kcn67stj	241	5	protein	protein	NN
cord-354050-kcn67stj	241	6	3	3	CD
cord-354050-kcn67stj	242	1	(	(	-LRB-
cord-354050-kcn67stj	242	2	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	242	3	)	)	-RRB-
cord-354050-kcn67stj	242	4	dually	dually	RB
cord-354050-kcn67stj	242	5	regulates	regulate	VBZ
cord-354050-kcn67stj	242	6	its	-PRON-	PRP$
cord-354050-kcn67stj	242	7	endocytosis	endocytosis	NN
cord-354050-kcn67stj	242	8	and	and	CC
cord-354050-kcn67stj	242	9	ubiquitination	ubiquitination	NNP
cord-354050-kcn67stj	242	10	Identification	identification	NN
cord-354050-kcn67stj	242	11	of	of	IN
cord-354050-kcn67stj	242	12	an	an	DT
cord-354050-kcn67stj	242	13	endocytic	endocytic	JJ
cord-354050-kcn67stj	242	14	signal	signal	NN
cord-354050-kcn67stj	242	15	essential	essential	NN
cord-354050-kcn67stj	242	16	for	for	IN
cord-354050-kcn67stj	242	17	the	the	DT
cord-354050-kcn67stj	242	18	antiviral	antiviral	JJ
cord-354050-kcn67stj	242	19	action	action	NN
cord-354050-kcn67stj	242	20	of	of	IN
cord-354050-kcn67stj	242	21	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	242	22	E3	E3	NNP
cord-354050-kcn67stj	242	23	ubiquitin	ubiquitin	NN
cord-354050-kcn67stj	242	24	ligase	ligase	NN
cord-354050-kcn67stj	243	1	NEDD4	NEDD4	NNP
cord-354050-kcn67stj	243	2	promotes	promote	VBZ
cord-354050-kcn67stj	243	3	influenza	influenza	NN
cord-354050-kcn67stj	243	4	virus	virus	NN
cord-354050-kcn67stj	243	5	infection	infection	NN
cord-354050-kcn67stj	243	6	by	by	IN
cord-354050-kcn67stj	243	7	decreasing	decrease	VBG
cord-354050-kcn67stj	243	8	levels	level	NNS
cord-354050-kcn67stj	243	9	of	of	IN
cord-354050-kcn67stj	243	10	the	the	DT
cord-354050-kcn67stj	243	11	antiviral	antiviral	JJ
cord-354050-kcn67stj	243	12	protein	protein	NN
cord-354050-kcn67stj	244	1	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	245	1	A	a	DT
cord-354050-kcn67stj	245	2	balancing	balancing	NN
cord-354050-kcn67stj	245	3	act	act	NN
cord-354050-kcn67stj	245	4	between	between	IN
cord-354050-kcn67stj	245	5	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	245	6	and	and	CC
cord-354050-kcn67stj	245	7	IRF3	IRF3	NNP
cord-354050-kcn67stj	245	8	Membrane	Membrane	NNP
cord-354050-kcn67stj	245	9	curvature	curvature	NN
cord-354050-kcn67stj	245	10	and	and	CC
cord-354050-kcn67stj	245	11	its	-PRON-	PRP$
cord-354050-kcn67stj	245	12	generation	generation	NN
cord-354050-kcn67stj	245	13	by	by	IN
cord-354050-kcn67stj	245	14	BAR	bar	NN
cord-354050-kcn67stj	245	15	proteins	protein	NNS
cord-354050-kcn67stj	245	16	Acid	acid	NN
cord-354050-kcn67stj	245	17	-	-	HYPH
cord-354050-kcn67stj	245	18	dependent	dependent	JJ
cord-354050-kcn67stj	245	19	viral	viral	JJ
cord-354050-kcn67stj	245	20	entry	entry	NN
cord-354050-kcn67stj	245	21	pH	ph	NN
cord-354050-kcn67stj	245	22	optimum	optimum	NN
cord-354050-kcn67stj	245	23	of	of	IN
cord-354050-kcn67stj	245	24	hemagglutinin	hemagglutinin	NN
cord-354050-kcn67stj	245	25	-	-	HYPH
cord-354050-kcn67stj	245	26	mediated	mediate	VBN
cord-354050-kcn67stj	245	27	membrane	membrane	NN
cord-354050-kcn67stj	245	28	fusion	fusion	NN
cord-354050-kcn67stj	245	29	determines	determine	VBZ
cord-354050-kcn67stj	245	30	sensitivity	sensitivity	NN
cord-354050-kcn67stj	245	31	of	of	IN
cord-354050-kcn67stj	245	32	influenza	influenza	NN
cord-354050-kcn67stj	245	33	A	a	DT
cord-354050-kcn67stj	245	34	viruses	virus	NNS
cord-354050-kcn67stj	245	35	to	to	IN
cord-354050-kcn67stj	245	36	the	the	DT
cord-354050-kcn67stj	245	37	interferon	interferon	NN
cord-354050-kcn67stj	245	38	-	-	HYPH
cord-354050-kcn67stj	245	39	induced	induce	VBN
cord-354050-kcn67stj	245	40	antiviral	antiviral	JJ
cord-354050-kcn67stj	245	41	state	state	NN
cord-354050-kcn67stj	245	42	and	and	CC
cord-354050-kcn67stj	245	43	IFITMs	IFITMs	JJR
cord-354050-kcn67stj	245	44	Host	host	NN
cord-354050-kcn67stj	245	45	cell	cell	NN
cord-354050-kcn67stj	245	46	factors	factor	NNS
cord-354050-kcn67stj	245	47	and	and	CC
cord-354050-kcn67stj	245	48	functions	function	NNS
cord-354050-kcn67stj	245	49	involved	involve	VBN
cord-354050-kcn67stj	245	50	in	in	IN
cord-354050-kcn67stj	245	51	vesicular	vesicular	JJ
cord-354050-kcn67stj	245	52	stomatitis	stomatitis	NN
cord-354050-kcn67stj	245	53	virus	virus	NN
cord-354050-kcn67stj	245	54	entry	entry	NN
cord-354050-kcn67stj	245	55	IFITM	IFITM	NNP
cord-354050-kcn67stj	245	56	proteins	protein	NNS
cord-354050-kcn67stj	245	57	restrict	restrict	VBP
cord-354050-kcn67stj	245	58	viral	viral	JJ
cord-354050-kcn67stj	245	59	membrane	membrane	NN
cord-354050-kcn67stj	245	60	hemifusion	hemifusion	NN
cord-354050-kcn67stj	246	1	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	246	2	restricts	restrict	VBZ
cord-354050-kcn67stj	246	3	influenza	influenza	NN
cord-354050-kcn67stj	246	4	A	a	DT
cord-354050-kcn67stj	246	5	virus	virus	NN
cord-354050-kcn67stj	246	6	entry	entry	NN
cord-354050-kcn67stj	246	7	by	by	IN
cord-354050-kcn67stj	246	8	blocking	block	VBG
cord-354050-kcn67stj	246	9	the	the	DT
cord-354050-kcn67stj	246	10	formation	formation	NN
cord-354050-kcn67stj	246	11	of	of	IN
cord-354050-kcn67stj	246	12	fusion	fusion	NN
cord-354050-kcn67stj	246	13	pores	pore	NNS
cord-354050-kcn67stj	246	14	following	follow	VBG
cord-354050-kcn67stj	247	1	virus	virus	NN
cord-354050-kcn67stj	247	2	-	-	HYPH
cord-354050-kcn67stj	247	3	endosome	endosome	NN
cord-354050-kcn67stj	247	4	hemifusion	hemifusion	NN
cord-354050-kcn67stj	247	5	Amphotericin	Amphotericin	NNP
cord-354050-kcn67stj	247	6	B	B	NNP
cord-354050-kcn67stj	247	7	increases	increase	VBZ
cord-354050-kcn67stj	247	8	influenza	influenza	NN
cord-354050-kcn67stj	247	9	A	a	DT
cord-354050-kcn67stj	247	10	virus	virus	NN
cord-354050-kcn67stj	247	11	infection	infection	NN
cord-354050-kcn67stj	247	12	by	by	IN
cord-354050-kcn67stj	247	13	preventing	prevent	VBG
cord-354050-kcn67stj	247	14	IFITM3-mediated	IFITM3-mediated	NNP
cord-354050-kcn67stj	247	15	restriction	restriction	NN
cord-354050-kcn67stj	248	1	The	the	DT
cord-354050-kcn67stj	248	2	antiviral	antiviral	JJ
cord-354050-kcn67stj	248	3	effector	effector	NN
cord-354050-kcn67stj	248	4	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	248	5	disrupts	disrupt	VBZ
cord-354050-kcn67stj	248	6	intracellular	intracellular	JJ
cord-354050-kcn67stj	248	7	cholesterol	cholesterol	NN
cord-354050-kcn67stj	248	8	homeostasis	homeostasis	NN
cord-354050-kcn67stj	248	9	to	to	TO
cord-354050-kcn67stj	248	10	block	block	VB
cord-354050-kcn67stj	248	11	viral	viral	JJ
cord-354050-kcn67stj	248	12	entry	entry	NN
cord-354050-kcn67stj	248	13	IFITM	IFITM	NNP
cord-354050-kcn67stj	248	14	proteins	protein	NNS
cord-354050-kcn67stj	248	15	inhibit	inhibit	VBP
cord-354050-kcn67stj	248	16	entry	entry	NN
cord-354050-kcn67stj	248	17	driven	drive	VBN
cord-354050-kcn67stj	248	18	by	by	IN
cord-354050-kcn67stj	248	19	the	the	DT
cord-354050-kcn67stj	248	20	MERS	MERS	NNP
cord-354050-kcn67stj	248	21	-	-	HYPH
cord-354050-kcn67stj	248	22	coronavirus	coronavirus	NN
cord-354050-kcn67stj	248	23	spike	spike	NN
cord-354050-kcn67stj	248	24	protein	protein	NN
cord-354050-kcn67stj	248	25	:	:	:
cord-354050-kcn67stj	248	26	evidence	evidence	NN
cord-354050-kcn67stj	248	27	for	for	IN
cord-354050-kcn67stj	248	28	cholesterol	cholesterol	NN
cord-354050-kcn67stj	248	29	-	-	HYPH
cord-354050-kcn67stj	248	30	independent	independent	JJ
cord-354050-kcn67stj	248	31	mechanisms	mechanism	NNS
cord-354050-kcn67stj	249	1	The	the	DT
cord-354050-kcn67stj	249	2	interferon	interferon	NN
cord-354050-kcn67stj	249	3	-	-	HYPH
cord-354050-kcn67stj	249	4	induced	induce	VBN
cord-354050-kcn67stj	249	5	transmembrane	transmembrane	NN
cord-354050-kcn67stj	249	6	proteins	protein	NNS
cord-354050-kcn67stj	249	7	,	,	,
cord-354050-kcn67stj	249	8	IFITM1	IFITM1	NNP
cord-354050-kcn67stj	249	9	,	,	,
cord-354050-kcn67stj	249	10	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	249	11	,	,	,
cord-354050-kcn67stj	249	12	and	and	CC
cord-354050-kcn67stj	249	13	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	249	14	inhibit	inhibit	VBP
cord-354050-kcn67stj	249	15	hepatitis	hepatitis	NN
cord-354050-kcn67stj	249	16	C	C	NNP
cord-354050-kcn67stj	249	17	virus	virus	NN
cord-354050-kcn67stj	249	18	entry	entry	NN
cord-354050-kcn67stj	250	1	Rhinovirus	rhinovirus	NN
cord-354050-kcn67stj	250	2	uses	use	VBZ
cord-354050-kcn67stj	250	3	a	a	DT
cord-354050-kcn67stj	250	4	phosphatidylinositol	phosphatidylinositol	JJ
cord-354050-kcn67stj	250	5	4-phosphate	4-phosphate	CD
cord-354050-kcn67stj	250	6	/	/	SYM
cord-354050-kcn67stj	250	7	cholesterol	cholesterol	NN
cord-354050-kcn67stj	250	8	counter	counter	NN
cord-354050-kcn67stj	250	9	-	-	NN
cord-354050-kcn67stj	250	10	current	current	JJ
cord-354050-kcn67stj	250	11	for	for	IN
cord-354050-kcn67stj	250	12	the	the	DT
cord-354050-kcn67stj	250	13	formation	formation	NN
cord-354050-kcn67stj	250	14	of	of	IN
cord-354050-kcn67stj	250	15	replication	replication	NN
cord-354050-kcn67stj	250	16	compartments	compartment	NNS
cord-354050-kcn67stj	250	17	at	at	IN
cord-354050-kcn67stj	250	18	the	the	DT
cord-354050-kcn67stj	250	19	ER	ER	NNP
cord-354050-kcn67stj	250	20	-	-	HYPH
cord-354050-kcn67stj	250	21	Golgi	Golgi	NNP
cord-354050-kcn67stj	250	22	interface	interface	NN
cord-354050-kcn67stj	250	23	Noroviruses	Noroviruses	NNP
cord-354050-kcn67stj	250	24	co	co	NN
cord-354050-kcn67stj	250	25	-	-	NN
cord-354050-kcn67stj	250	26	opt	opt	VB
cord-354050-kcn67stj	250	27	the	the	DT
cord-354050-kcn67stj	250	28	function	function	NN
cord-354050-kcn67stj	250	29	of	of	IN
cord-354050-kcn67stj	250	30	host	host	NN
cord-354050-kcn67stj	250	31	proteins	protein	NNS
cord-354050-kcn67stj	250	32	VAPA	VAPA	NNP
cord-354050-kcn67stj	250	33	and	and	CC
cord-354050-kcn67stj	250	34	VAPB	vapb	NN
cord-354050-kcn67stj	250	35	for	for	IN
cord-354050-kcn67stj	250	36	replication	replication	NN
cord-354050-kcn67stj	250	37	via	via	IN
cord-354050-kcn67stj	250	38	a	a	DT
cord-354050-kcn67stj	250	39	phenylalaninephenylalanine	phenylalaninephenylalanine	JJ
cord-354050-kcn67stj	250	40	-	-	HYPH
cord-354050-kcn67stj	250	41	acidic	acidic	JJ
cord-354050-kcn67stj	250	42	-	-	HYPH
cord-354050-kcn67stj	250	43	tract	tract	NN
cord-354050-kcn67stj	250	44	-	-	HYPH
cord-354050-kcn67stj	250	45	motif	motif	NN
cord-354050-kcn67stj	250	46	mimic	mimic	VBP
cord-354050-kcn67stj	250	47	in	in	IN
cord-354050-kcn67stj	250	48	nonstructural	nonstructural	JJ
cord-354050-kcn67stj	250	49	viral	viral	JJ
cord-354050-kcn67stj	250	50	protein	protein	NN
cord-354050-kcn67stj	250	51	NS1/2	NS1/2	NNP
cord-354050-kcn67stj	250	52	CD81	CD81	NNP
cord-354050-kcn67stj	250	53	(	(	-LRB-
cord-354050-kcn67stj	250	54	TAPA-1	TAPA-1	NNP
cord-354050-kcn67stj	250	55	)	)	-RRB-
cord-354050-kcn67stj	250	56	:	:	:
cord-354050-kcn67stj	250	57	a	a	DT
cord-354050-kcn67stj	250	58	molecule	molecule	NN
cord-354050-kcn67stj	250	59	involved	involve	VBN
cord-354050-kcn67stj	250	60	in	in	IN
cord-354050-kcn67stj	250	61	signal	signal	NN
cord-354050-kcn67stj	250	62	transduction	transduction	NN
cord-354050-kcn67stj	250	63	and	and	CC
cord-354050-kcn67stj	250	64	cell	cell	NN
cord-354050-kcn67stj	250	65	adhesion	adhesion	NN
cord-354050-kcn67stj	250	66	in	in	IN
cord-354050-kcn67stj	250	67	the	the	DT
cord-354050-kcn67stj	250	68	immune	immune	JJ
cord-354050-kcn67stj	250	69	system	system	NN
cord-354050-kcn67stj	251	1	IFITM1	IFITM1	NNP
cord-354050-kcn67stj	251	2	is	be	VBZ
cord-354050-kcn67stj	251	3	a	a	DT
cord-354050-kcn67stj	251	4	tight	tight	JJ
cord-354050-kcn67stj	251	5	junction	junction	NN
cord-354050-kcn67stj	251	6	protein	protein	NN
cord-354050-kcn67stj	251	7	that	that	WDT
cord-354050-kcn67stj	251	8	inhibits	inhibit	VBZ
cord-354050-kcn67stj	251	9	hepatitis	hepatitis	NN
cord-354050-kcn67stj	251	10	C	C	NNP
cord-354050-kcn67stj	251	11	virus	virus	NN
cord-354050-kcn67stj	251	12	entry	entry	NN
cord-354050-kcn67stj	252	1	The	the	DT
cord-354050-kcn67stj	252	2	role	role	NN
cord-354050-kcn67stj	252	3	of	of	IN
cord-354050-kcn67stj	252	4	tetraspanins	tetraspanin	NNS
cord-354050-kcn67stj	252	5	in	in	IN
cord-354050-kcn67stj	252	6	fusion	fusion	NN
cord-354050-kcn67stj	252	7	Evidence	evidence	NN
cord-354050-kcn67stj	252	8	showing	show	VBG
cord-354050-kcn67stj	252	9	that	that	IN
cord-354050-kcn67stj	252	10	tetraspanins	tetraspanin	NNS
cord-354050-kcn67stj	252	11	inhibit	inhibit	VBP
cord-354050-kcn67stj	252	12	HIV-1-induced	hiv-1-induced	JJ
cord-354050-kcn67stj	252	13	cell	cell	NN
cord-354050-kcn67stj	252	14	-	-	HYPH
cord-354050-kcn67stj	252	15	cell	cell	NN
cord-354050-kcn67stj	252	16	fusion	fusion	NN
cord-354050-kcn67stj	252	17	at	at	IN
cord-354050-kcn67stj	252	18	a	a	DT
cord-354050-kcn67stj	252	19	post	post	JJ
cord-354050-kcn67stj	252	20	-	-	JJ
cord-354050-kcn67stj	252	21	hemifusion	hemifusion	JJ
cord-354050-kcn67stj	252	22	stage	stage	NN
cord-354050-kcn67stj	252	23	Tetraspanins	Tetraspanins	NNP
cord-354050-kcn67stj	252	24	CD9	CD9	NNP
cord-354050-kcn67stj	252	25	and	and	CC
cord-354050-kcn67stj	252	26	CD81	CD81	NNP
cord-354050-kcn67stj	252	27	function	function	NN
cord-354050-kcn67stj	252	28	to	to	TO
cord-354050-kcn67stj	252	29	prevent	prevent	VB
cord-354050-kcn67stj	252	30	the	the	DT
cord-354050-kcn67stj	252	31	fusion	fusion	NN
cord-354050-kcn67stj	252	32	of	of	IN
cord-354050-kcn67stj	252	33	mononuclear	mononuclear	JJ
cord-354050-kcn67stj	252	34	phagocytes	phagocyte	NNS
cord-354050-kcn67stj	252	35	Formation	Formation	NNP
cord-354050-kcn67stj	252	36	of	of	IN
cord-354050-kcn67stj	252	37	syncytia	syncytia	NN
cord-354050-kcn67stj	252	38	is	be	VBZ
cord-354050-kcn67stj	252	39	repressed	repress	VBN
cord-354050-kcn67stj	252	40	by	by	IN
cord-354050-kcn67stj	252	41	tetraspanins	tetraspanin	NNS
cord-354050-kcn67stj	252	42	in	in	IN
cord-354050-kcn67stj	252	43	human	human	JJ
cord-354050-kcn67stj	252	44	immunodeficiency	immunodeficiency	NN
cord-354050-kcn67stj	252	45	virus	virus	NN
cord-354050-kcn67stj	252	46	type	type	NN
cord-354050-kcn67stj	252	47	1-producing	1-producing	CD
cord-354050-kcn67stj	252	48	cells	cell	NNS
cord-354050-kcn67stj	253	1	Interferon	interferon	NN
cord-354050-kcn67stj	253	2	induction	induction	NN
cord-354050-kcn67stj	253	3	of	of	IN
cord-354050-kcn67stj	253	4	IFITM	IFITM	NNP
cord-354050-kcn67stj	253	5	proteins	protein	NNS
cord-354050-kcn67stj	253	6	promotes	promote	VBZ
cord-354050-kcn67stj	253	7	infection	infection	NN
cord-354050-kcn67stj	253	8	by	by	IN
cord-354050-kcn67stj	253	9	human	human	JJ
cord-354050-kcn67stj	253	10	coronavirus	coronavirus	NN
cord-354050-kcn67stj	253	11	OC43	OC43	NNP
cord-354050-kcn67stj	253	12	ZMPSTE24	ZMPSTE24	NNP
cord-354050-kcn67stj	253	13	defends	defend	VBZ
cord-354050-kcn67stj	253	14	against	against	IN
cord-354050-kcn67stj	253	15	influenza	influenza	NN
cord-354050-kcn67stj	253	16	and	and	CC
cord-354050-kcn67stj	253	17	other	other	JJ
cord-354050-kcn67stj	253	18	pathogenic	pathogenic	JJ
cord-354050-kcn67stj	253	19	viruses	virus	NNS
cord-354050-kcn67stj	253	20	On	on	IN
cord-354050-kcn67stj	253	21	the	the	DT
cord-354050-kcn67stj	253	22	whereabouts	whereabouts	NN
cord-354050-kcn67stj	253	23	of	of	IN
cord-354050-kcn67stj	253	24	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	253	25	cellular	cellular	JJ
cord-354050-kcn67stj	253	26	entry	entry	NN
cord-354050-kcn67stj	253	27	and	and	CC
cord-354050-kcn67stj	253	28	its	-PRON-	PRP$
cord-354050-kcn67stj	253	29	fusion	fusion	NN
cord-354050-kcn67stj	253	30	ports	port	NNS
cord-354050-kcn67stj	254	1	Unique	unique	JJ
cord-354050-kcn67stj	254	2	features	feature	NNS
cord-354050-kcn67stj	254	3	of	of	IN
cord-354050-kcn67stj	254	4	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	254	5	spread	spread	VBD
cord-354050-kcn67stj	254	6	through	through	IN
cord-354050-kcn67stj	254	7	T	T	NNP
cord-354050-kcn67stj	254	8	cell	cell	NN
cord-354050-kcn67stj	254	9	virological	virological	JJ
cord-354050-kcn67stj	254	10	synapses	synapsis	NNS
cord-354050-kcn67stj	255	1	Tetherin	Tetherin	NNP
cord-354050-kcn67stj	255	2	inhibits	inhibit	VBZ
cord-354050-kcn67stj	255	3	retrovirus	retrovirus	NN
cord-354050-kcn67stj	255	4	release	release	NN
cord-354050-kcn67stj	255	5	and	and	CC
cord-354050-kcn67stj	255	6	is	be	VBZ
cord-354050-kcn67stj	255	7	antagonized	antagonize	VBN
cord-354050-kcn67stj	255	8	by	by	IN
cord-354050-kcn67stj	256	1	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	256	2	Vpu	Vpu	NNP
cord-354050-kcn67stj	256	3	The	the	DT
cord-354050-kcn67stj	256	4	IFITM	IFITM	NNP
cord-354050-kcn67stj	256	5	proteins	protein	NNS
cord-354050-kcn67stj	256	6	inhibit	inhibit	VBP
cord-354050-kcn67stj	256	7	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	256	8	infection	infection	NN
cord-354050-kcn67stj	257	1	A	a	DT
cord-354050-kcn67stj	257	2	diverse	diverse	JJ
cord-354050-kcn67stj	257	3	range	range	NN
cord-354050-kcn67stj	257	4	of	of	IN
cord-354050-kcn67stj	257	5	gene	gene	NN
cord-354050-kcn67stj	257	6	products	product	NNS
cord-354050-kcn67stj	257	7	are	be	VBP
cord-354050-kcn67stj	257	8	effectors	effector	NNS
cord-354050-kcn67stj	257	9	of	of	IN
cord-354050-kcn67stj	257	10	the	the	DT
cord-354050-kcn67stj	257	11	type	type	NN
cord-354050-kcn67stj	258	1	I	-PRON-	PRP
cord-354050-kcn67stj	258	2	interferon	interferon	VBP
cord-354050-kcn67stj	258	3	antiviral	antiviral	JJ
cord-354050-kcn67stj	258	4	response	response	NN
cord-354050-kcn67stj	259	1	Primate	primate	JJ
cord-354050-kcn67stj	259	2	lentiviruses	lentiviruse	NNS
cord-354050-kcn67stj	259	3	are	be	VBP
cord-354050-kcn67stj	259	4	differentially	differentially	RB
cord-354050-kcn67stj	259	5	inhibited	inhibit	VBN
cord-354050-kcn67stj	259	6	by	by	IN
cord-354050-kcn67stj	259	7	interferon	interferon	NN
cord-354050-kcn67stj	259	8	-	-	HYPH
cord-354050-kcn67stj	259	9	induced	induce	VBN
cord-354050-kcn67stj	259	10	transmembrane	transmembrane	NN
cord-354050-kcn67stj	259	11	proteins	protein	NNS
cord-354050-kcn67stj	259	12	Virion	Virion	NNP
cord-354050-kcn67stj	259	13	background	background	NN
cord-354050-kcn67stj	259	14	and	and	CC
cord-354050-kcn67stj	259	15	efficiency	efficiency	NN
cord-354050-kcn67stj	259	16	of	of	IN
cord-354050-kcn67stj	259	17	virion	virion	NN
cord-354050-kcn67stj	259	18	incorporation	incorporation	NN
cord-354050-kcn67stj	259	19	determine	determine	VBP
cord-354050-kcn67stj	259	20	susceptibility	susceptibility	NN
cord-354050-kcn67stj	259	21	of	of	IN
cord-354050-kcn67stj	259	22	simian	simian	JJ
cord-354050-kcn67stj	259	23	immunodeficiency	immunodeficiency	NN
cord-354050-kcn67stj	259	24	virus	virus	NN
cord-354050-kcn67stj	259	25	env	env	NN
cord-354050-kcn67stj	259	26	-	-	HYPH
cord-354050-kcn67stj	259	27	driven	drive	VBN
cord-354050-kcn67stj	259	28	viral	viral	JJ
cord-354050-kcn67stj	259	29	entry	entry	NN
cord-354050-kcn67stj	259	30	to	to	IN
cord-354050-kcn67stj	259	31	inhibition	inhibition	NN
cord-354050-kcn67stj	259	32	by	by	IN
cord-354050-kcn67stj	259	33	IFITM	IFITM	NNP
cord-354050-kcn67stj	259	34	proteins	protein	NNS
cord-354050-kcn67stj	259	35	Resistance	Resistance	NNP
cord-354050-kcn67stj	259	36	of	of	IN
cord-354050-kcn67stj	259	37	transmitted	transmit	VBN
cord-354050-kcn67stj	259	38	founder	founder	NN
cord-354050-kcn67stj	259	39	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	259	40	to	to	IN
cord-354050-kcn67stj	259	41	IFITM	IFITM	NNP
cord-354050-kcn67stj	259	42	-	-	HYPH
cord-354050-kcn67stj	259	43	mediated	mediate	VBN
cord-354050-kcn67stj	259	44	restriction	restriction	NN
cord-354050-kcn67stj	259	45	Coupling	coupling	NN
cord-354050-kcn67stj	259	46	of	of	IN
cord-354050-kcn67stj	259	47	replication	replication	NN
cord-354050-kcn67stj	259	48	and	and	CC
cord-354050-kcn67stj	259	49	assembly	assembly	NN
cord-354050-kcn67stj	259	50	in	in	IN
cord-354050-kcn67stj	259	51	flaviviruses	flavivirus	NNS
cord-354050-kcn67stj	260	1	Δ20	Δ20	NNP
cord-354050-kcn67stj	260	2	IFITM2	ifitm2	XX
cord-354050-kcn67stj	260	3	differentially	differentially	RB
cord-354050-kcn67stj	260	4	restricts	restrict	VBZ
cord-354050-kcn67stj	260	5	X4	X4	NNP
cord-354050-kcn67stj	260	6	and	and	CC
cord-354050-kcn67stj	260	7	R5	R5	NNP
cord-354050-kcn67stj	260	8	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	260	9	IFITM	IFITM	NNP
cord-354050-kcn67stj	260	10	proteins	protein	NNS
cord-354050-kcn67stj	260	11	incorporated	incorporate	VBN
cord-354050-kcn67stj	260	12	into	into	IN
cord-354050-kcn67stj	260	13	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	260	14	virions	virion	NNS
cord-354050-kcn67stj	260	15	impair	impair	VBP
cord-354050-kcn67stj	260	16	viral	viral	JJ
cord-354050-kcn67stj	260	17	fusion	fusion	NN
cord-354050-kcn67stj	260	18	and	and	CC
cord-354050-kcn67stj	260	19	spread	spread	VBD
cord-354050-kcn67stj	260	20	IFITM	IFITM	NNP
cord-354050-kcn67stj	260	21	proteins	protein	NNS
cord-354050-kcn67stj	260	22	are	be	VBP
cord-354050-kcn67stj	260	23	incorporated	incorporate	VBN
cord-354050-kcn67stj	260	24	onto	onto	IN
cord-354050-kcn67stj	260	25	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	260	26	virion	virion	NN
cord-354050-kcn67stj	260	27	particles	particle	NNS
cord-354050-kcn67stj	260	28	and	and	CC
cord-354050-kcn67stj	260	29	negatively	negatively	RB
cord-354050-kcn67stj	260	30	imprint	imprint	VB
cord-354050-kcn67stj	260	31	their	-PRON-	PRP$
cord-354050-kcn67stj	260	32	infectivity	infectivity	NN
cord-354050-kcn67stj	260	33	IFITM	IFITM	NNP
cord-354050-kcn67stj	260	34	proteins	protein	NNS
cord-354050-kcn67stj	260	35	restrict	restrict	VBP
cord-354050-kcn67stj	260	36	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	260	37	infection	infection	NN
cord-354050-kcn67stj	260	38	by	by	IN
cord-354050-kcn67stj	260	39	antagonizing	antagonize	VBG
cord-354050-kcn67stj	260	40	the	the	DT
cord-354050-kcn67stj	260	41	envelope	envelope	NN
cord-354050-kcn67stj	260	42	glycoprotein	glycoprotein	NN
cord-354050-kcn67stj	260	43	Nonhuman	nonhuman	JJ
cord-354050-kcn67stj	260	44	primate	primate	JJ
cord-354050-kcn67stj	260	45	IFITM	IFITM	NNP
cord-354050-kcn67stj	260	46	proteins	protein	NNS
cord-354050-kcn67stj	260	47	are	be	VBP
cord-354050-kcn67stj	260	48	potent	potent	JJ
cord-354050-kcn67stj	260	49	inhibitors	inhibitor	NNS
cord-354050-kcn67stj	260	50	of	of	IN
cord-354050-kcn67stj	260	51	HIV	HIV	NNP
cord-354050-kcn67stj	260	52	and	and	CC
cord-354050-kcn67stj	260	53	SIV	SIV	NNP
cord-354050-kcn67stj	261	1	The	the	DT
cord-354050-kcn67stj	261	2	V3	V3	NNP
cord-354050-kcn67stj	261	3	loop	loop	NN
cord-354050-kcn67stj	261	4	of	of	IN
cord-354050-kcn67stj	261	5	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	261	6	Env	Env	NNP
cord-354050-kcn67stj	261	7	determines	determine	VBZ
cord-354050-kcn67stj	261	8	viral	viral	JJ
cord-354050-kcn67stj	261	9	susceptibility	susceptibility	NN
cord-354050-kcn67stj	261	10	to	to	IN
cord-354050-kcn67stj	261	11	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	261	12	impairment	impairment	NN
cord-354050-kcn67stj	261	13	of	of	IN
cord-354050-kcn67stj	261	14	viral	viral	JJ
cord-354050-kcn67stj	261	15	infectivity	infectivity	NN
cord-354050-kcn67stj	261	16	Interference	Interference	NNP
cord-354050-kcn67stj	261	17	with	with	IN
cord-354050-kcn67stj	261	18	the	the	DT
cord-354050-kcn67stj	261	19	production	production	NN
cord-354050-kcn67stj	261	20	of	of	IN
cord-354050-kcn67stj	261	21	infectious	infectious	JJ
cord-354050-kcn67stj	261	22	viral	viral	JJ
cord-354050-kcn67stj	261	23	particles	particle	NNS
cord-354050-kcn67stj	261	24	and	and	CC
cord-354050-kcn67stj	261	25	bimodal	bimodal	JJ
cord-354050-kcn67stj	261	26	inhibition	inhibition	NN
cord-354050-kcn67stj	261	27	of	of	IN
cord-354050-kcn67stj	261	28	replication	replication	NN
cord-354050-kcn67stj	261	29	are	be	VBP
cord-354050-kcn67stj	261	30	broadly	broadly	RB
cord-354050-kcn67stj	261	31	conserved	conserve	VBN
cord-354050-kcn67stj	261	32	antiviral	antiviral	JJ
cord-354050-kcn67stj	261	33	properties	property	NNS
cord-354050-kcn67stj	261	34	of	of	IN
cord-354050-kcn67stj	261	35	IFITMs	ifitm	NNS
cord-354050-kcn67stj	262	1	The	the	DT
cord-354050-kcn67stj	262	2	V3-loop	V3-loop	NNS
cord-354050-kcn67stj	262	3	of	of	IN
cord-354050-kcn67stj	262	4	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	262	5	Env	Env	NNP
cord-354050-kcn67stj	262	6	determines	determine	VBZ
cord-354050-kcn67stj	262	7	viral	viral	JJ
cord-354050-kcn67stj	262	8	susceptibility	susceptibility	NN
cord-354050-kcn67stj	262	9	to	to	IN
cord-354050-kcn67stj	262	10	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	262	11	impairment	impairment	NN
cord-354050-kcn67stj	262	12	of	of	IN
cord-354050-kcn67stj	262	13	viral	viral	JJ
cord-354050-kcn67stj	262	14	infectivity	infectivity	NN
cord-354050-kcn67stj	262	15	Delineating	delineate	VBG
cord-354050-kcn67stj	262	16	CD4	CD4	NNP
cord-354050-kcn67stj	262	17	dependency	dependency	NN
cord-354050-kcn67stj	262	18	of	of	IN
cord-354050-kcn67stj	262	19	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	262	20	:	:	:
cord-354050-kcn67stj	262	21	adaptation	adaptation	NN
cord-354050-kcn67stj	262	22	to	to	TO
cord-354050-kcn67stj	262	23	infect	infect	VB
cord-354050-kcn67stj	262	24	low	low	JJ
cord-354050-kcn67stj	262	25	level	level	NN
cord-354050-kcn67stj	262	26	CD4	CD4	NNP
cord-354050-kcn67stj	262	27	expressing	express	VBG
cord-354050-kcn67stj	262	28	target	target	NN
cord-354050-kcn67stj	262	29	cells	cell	NNS
cord-354050-kcn67stj	262	30	widens	widen	VBZ
cord-354050-kcn67stj	262	31	cellular	cellular	JJ
cord-354050-kcn67stj	262	32	tropism	tropism	NN
cord-354050-kcn67stj	262	33	but	but	CC
cord-354050-kcn67stj	262	34	severely	severely	RB
cord-354050-kcn67stj	262	35	impacts	impact	VBZ
cord-354050-kcn67stj	262	36	on	on	IN
cord-354050-kcn67stj	262	37	envelope	envelope	NN
cord-354050-kcn67stj	262	38	functionality	functionality	NN
cord-354050-kcn67stj	262	39	Resistance	resistance	NN
cord-354050-kcn67stj	262	40	to	to	TO
cord-354050-kcn67stj	262	41	type	type	NN
cord-354050-kcn67stj	262	42	1	1	CD
cord-354050-kcn67stj	262	43	interferons	interferon	NNS
cord-354050-kcn67stj	262	44	is	be	VBZ
cord-354050-kcn67stj	262	45	a	a	DT
cord-354050-kcn67stj	262	46	major	major	JJ
cord-354050-kcn67stj	262	47	determinant	determinant	NN
cord-354050-kcn67stj	262	48	of	of	IN
cord-354050-kcn67stj	262	49	HIV-1	HIV-1	NNP
cord-354050-kcn67stj	262	50	transmission	transmission	NN
cord-354050-kcn67stj	262	51	fitness	fitness	NN
cord-354050-kcn67stj	263	1	The	the	DT
cord-354050-kcn67stj	263	2	IFITMs	ifitm	NNS
cord-354050-kcn67stj	263	3	inhibit	inhibit	VBP
cord-354050-kcn67stj	264	1	Zika	Zika	NNP
cord-354050-kcn67stj	264	2	virus	virus	NN
cord-354050-kcn67stj	264	3	replication	replication	NN
cord-354050-kcn67stj	264	4	Zika	Zika	NNP
cord-354050-kcn67stj	264	5	virus	virus	NN
cord-354050-kcn67stj	264	6	induces	induce	VBZ
cord-354050-kcn67stj	264	7	massive	massive	JJ
cord-354050-kcn67stj	264	8	cytoplasmic	cytoplasmic	JJ
cord-354050-kcn67stj	264	9	vacuolization	vacuolization	NN
cord-354050-kcn67stj	264	10	and	and	CC
cord-354050-kcn67stj	264	11	paraptosis	paraptosis	NN
cord-354050-kcn67stj	264	12	-	-	HYPH
cord-354050-kcn67stj	264	13	like	like	JJ
cord-354050-kcn67stj	264	14	death	death	NN
cord-354050-kcn67stj	264	15	in	in	IN
cord-354050-kcn67stj	264	16	infected	infected	JJ
cord-354050-kcn67stj	264	17	cells	cell	NNS
cord-354050-kcn67stj	265	1	Ifitm3	Ifitm3	NNP
cord-354050-kcn67stj	265	2	limits	limit	VBZ
cord-354050-kcn67stj	265	3	the	the	DT
cord-354050-kcn67stj	265	4	severity	severity	NN
cord-354050-kcn67stj	265	5	of	of	IN
cord-354050-kcn67stj	265	6	acute	acute	JJ
cord-354050-kcn67stj	265	7	influenza	influenza	NN
cord-354050-kcn67stj	265	8	in	in	IN
cord-354050-kcn67stj	265	9	mice	mouse	NNS
cord-354050-kcn67stj	266	1	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	266	2	restricts	restrict	VBZ
cord-354050-kcn67stj	266	3	the	the	DT
cord-354050-kcn67stj	266	4	morbidity	morbidity	NN
cord-354050-kcn67stj	266	5	and	and	CC
cord-354050-kcn67stj	266	6	mortality	mortality	NN
cord-354050-kcn67stj	266	7	associated	associate	VBN
cord-354050-kcn67stj	266	8	with	with	IN
cord-354050-kcn67stj	266	9	influenza	influenza	JJ
cord-354050-kcn67stj	266	10	Respiratory	respiratory	JJ
cord-354050-kcn67stj	266	11	DC	DC	NNP
cord-354050-kcn67stj	266	12	Use	Use	NNP
cord-354050-kcn67stj	266	13	IFITM3	IFITM3	''
cord-354050-kcn67stj	266	14	to	to	TO
cord-354050-kcn67stj	266	15	avoid	avoid	VB
cord-354050-kcn67stj	266	16	direct	direct	JJ
cord-354050-kcn67stj	266	17	viral	viral	JJ
cord-354050-kcn67stj	266	18	infection	infection	NN
cord-354050-kcn67stj	266	19	and	and	CC
cord-354050-kcn67stj	266	20	safeguard	safeguard	NN
cord-354050-kcn67stj	266	21	virus	virus	NN
cord-354050-kcn67stj	266	22	-	-	HYPH
cord-354050-kcn67stj	266	23	specific	specific	JJ
cord-354050-kcn67stj	266	24	CD8	CD8	NNP
cord-354050-kcn67stj	266	25	+	+	CC
cord-354050-kcn67stj	266	26	T	t	NN
cord-354050-kcn67stj	266	27	cell	cell	NN
cord-354050-kcn67stj	266	28	priming	prime	VBG
cord-354050-kcn67stj	266	29	Enhanced	enhanced	JJ
cord-354050-kcn67stj	266	30	survival	survival	NN
cord-354050-kcn67stj	266	31	of	of	IN
cord-354050-kcn67stj	266	32	lung	lung	NN
cord-354050-kcn67stj	266	33	tissue	tissue	NN
cord-354050-kcn67stj	266	34	-	-	HYPH
cord-354050-kcn67stj	266	35	resident	resident	NN
cord-354050-kcn67stj	266	36	memory	memory	NN
cord-354050-kcn67stj	266	37	CD8	CD8	NNP
cord-354050-kcn67stj	266	38	+	+	CC
cord-354050-kcn67stj	266	39	T	T	NNP
cord-354050-kcn67stj	266	40	cells	cell	NNS
cord-354050-kcn67stj	266	41	during	during	IN
cord-354050-kcn67stj	266	42	infection	infection	NN
cord-354050-kcn67stj	266	43	with	with	IN
cord-354050-kcn67stj	266	44	influenza	influenza	NN
cord-354050-kcn67stj	266	45	virus	virus	NN
cord-354050-kcn67stj	266	46	due	due	IN
cord-354050-kcn67stj	266	47	to	to	IN
cord-354050-kcn67stj	266	48	selective	selective	JJ
cord-354050-kcn67stj	266	49	expression	expression	NN
cord-354050-kcn67stj	266	50	of	of	IN
cord-354050-kcn67stj	266	51	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	267	1	The	the	DT
cord-354050-kcn67stj	267	2	interferonstimulated	interferonstimulate	VBN
cord-354050-kcn67stj	267	3	gene	gene	NN
cord-354050-kcn67stj	267	4	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	267	5	restricts	restrict	VBZ
cord-354050-kcn67stj	267	6	infection	infection	NN
cord-354050-kcn67stj	267	7	and	and	CC
cord-354050-kcn67stj	267	8	pathogenesis	pathogenesis	NN
cord-354050-kcn67stj	267	9	of	of	IN
cord-354050-kcn67stj	267	10	arthritogenic	arthritogenic	NNP
cord-354050-kcn67stj	267	11	and	and	CC
cord-354050-kcn67stj	267	12	encephalitic	encephalitic	NNP
cord-354050-kcn67stj	267	13	alphaviruses	alphavirus	NNS
cord-354050-kcn67stj	268	1	The	the	DT
cord-354050-kcn67stj	268	2	interferon	interferon	NN
cord-354050-kcn67stj	268	3	-	-	HYPH
cord-354050-kcn67stj	268	4	stimulated	stimulate	VBN
cord-354050-kcn67stj	268	5	gene	gene	NN
cord-354050-kcn67stj	268	6	Ifitm3	Ifitm3	NNP
cord-354050-kcn67stj	268	7	restricts	restrict	VBZ
cord-354050-kcn67stj	268	8	west	west	NNP
cord-354050-kcn67stj	268	9	nile	nile	NNP
cord-354050-kcn67stj	268	10	virus	virus	NN
cord-354050-kcn67stj	268	11	infection	infection	NN
cord-354050-kcn67stj	268	12	and	and	CC
cord-354050-kcn67stj	268	13	pathogenesis	pathogenesis	NN
cord-354050-kcn67stj	268	14	Human	human	JJ
cord-354050-kcn67stj	268	15	cytomegalovirus	cytomegalovirus	NN
cord-354050-kcn67stj	268	16	exploits	exploit	VBZ
cord-354050-kcn67stj	268	17	interferon	interferon	NN
cord-354050-kcn67stj	268	18	-	-	HYPH
cord-354050-kcn67stj	268	19	induced	induce	VBN
cord-354050-kcn67stj	268	20	transmembrane	transmembrane	NN
cord-354050-kcn67stj	268	21	proteins	protein	NNS
cord-354050-kcn67stj	268	22	to	to	TO
cord-354050-kcn67stj	268	23	facilitate	facilitate	VB
cord-354050-kcn67stj	268	24	morphogenesis	morphogenesis	NN
cord-354050-kcn67stj	268	25	of	of	IN
cord-354050-kcn67stj	268	26	the	the	DT
cord-354050-kcn67stj	268	27	virion	virion	NNP
cord-354050-kcn67stj	268	28	assembly	assembly	NNP
cord-354050-kcn67stj	268	29	compartment	compartment	NN
cord-354050-kcn67stj	269	1	The	the	DT
cord-354050-kcn67stj	269	2	antiviral	antiviral	JJ
cord-354050-kcn67stj	269	3	restriction	restriction	NN
cord-354050-kcn67stj	269	4	factor	factor	NN
cord-354050-kcn67stj	269	5	IFN	IFN	NNP
cord-354050-kcn67stj	269	6	-	-	HYPH
cord-354050-kcn67stj	269	7	induced	induce	VBN
cord-354050-kcn67stj	269	8	transmembrane	transmembrane	NN
cord-354050-kcn67stj	269	9	protein	protein	NN
cord-354050-kcn67stj	269	10	3	3	CD
cord-354050-kcn67stj	269	11	prevents	prevent	VBZ
cord-354050-kcn67stj	269	12	cytokine	cytokine	NN
cord-354050-kcn67stj	269	13	-	-	HYPH
cord-354050-kcn67stj	269	14	driven	drive	VBN
cord-354050-kcn67stj	269	15	CMV	CMV	NNP
cord-354050-kcn67stj	269	16	pathogenesis	pathogenesis	NN
cord-354050-kcn67stj	269	17	Palmitoylation	Palmitoylation	NNP
cord-354050-kcn67stj	269	18	on	on	IN
cord-354050-kcn67stj	269	19	conserved	conserved	JJ
cord-354050-kcn67stj	269	20	and	and	CC
cord-354050-kcn67stj	269	21	nonconserved	nonconserved	JJ
cord-354050-kcn67stj	269	22	cysteines	cysteine	NNS
cord-354050-kcn67stj	269	23	of	of	IN
cord-354050-kcn67stj	269	24	murine	murine	JJ
cord-354050-kcn67stj	269	25	IFITM1	IFITM1	NNP
cord-354050-kcn67stj	269	26	regulates	regulate	VBZ
cord-354050-kcn67stj	269	27	its	-PRON-	PRP$
cord-354050-kcn67stj	269	28	stability	stability	NN
cord-354050-kcn67stj	269	29	and	and	CC
cord-354050-kcn67stj	269	30	anti	anti	JJ
cord-354050-kcn67stj	269	31	-	-	JJ
cord-354050-kcn67stj	269	32	influenza	influenza	JJ
cord-354050-kcn67stj	269	33	A	a	DT
cord-354050-kcn67stj	269	34	virus	virus	NN
cord-354050-kcn67stj	269	35	activity	activity	NN
cord-354050-kcn67stj	270	1	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	270	2	inhibits	inhibit	VBZ
cord-354050-kcn67stj	270	3	virus	virus	NN
cord-354050-kcn67stj	270	4	-	-	HYPH
cord-354050-kcn67stj	270	5	triggered	trigger	VBN
cord-354050-kcn67stj	270	6	induction	induction	NN
cord-354050-kcn67stj	270	7	of	of	IN
cord-354050-kcn67stj	270	8	type	type	NN
cord-354050-kcn67stj	271	1	I	-PRON-	PRP
cord-354050-kcn67stj	271	2	interferon	interferon	RB
cord-354050-kcn67stj	272	1	by	by	IN
cord-354050-kcn67stj	272	2	mediating	mediate	VBG
cord-354050-kcn67stj	272	3	Submit	submit	VB
cord-354050-kcn67stj	272	4	your	-PRON-	PRP$
cord-354050-kcn67stj	272	5	next	next	JJ
cord-354050-kcn67stj	272	6	manuscript	manuscript	NN
cord-354050-kcn67stj	272	7	to	to	IN
cord-354050-kcn67stj	272	8	BioMed	BioMed	NNP
cord-354050-kcn67stj	272	9	Central	Central	NNP
cord-354050-kcn67stj	272	10	and	and	CC
cord-354050-kcn67stj	272	11	we	-PRON-	PRP
cord-354050-kcn67stj	272	12	will	will	MD
cord-354050-kcn67stj	272	13	help	help	VB
cord-354050-kcn67stj	272	14	you	-PRON-	PRP
cord-354050-kcn67stj	272	15	at	at	IN
cord-354050-kcn67stj	272	16	every	every	DT
cord-354050-kcn67stj	272	17	step	step	NN
cord-354050-kcn67stj	272	18	:	:	:
cord-354050-kcn67stj	273	1	autophagosome	autophagosome	NN
cord-354050-kcn67stj	273	2	-	-	HYPH
cord-354050-kcn67stj	273	3	dependent	dependent	JJ
cord-354050-kcn67stj	273	4	degradation	degradation	NN
cord-354050-kcn67stj	273	5	of	of	IN
cord-354050-kcn67stj	273	6	IRF3	IRF3	NNP
cord-354050-kcn67stj	273	7	SNP	SNP	NNP
cord-354050-kcn67stj	273	8	-	-	HYPH
cord-354050-kcn67stj	273	9	mediated	mediate	VBN
cord-354050-kcn67stj	273	10	disruption	disruption	NN
cord-354050-kcn67stj	273	11	of	of	IN
cord-354050-kcn67stj	273	12	CTCF	CTCF	NNP
cord-354050-kcn67stj	273	13	binding	bind	VBG
cord-354050-kcn67stj	273	14	at	at	IN
cord-354050-kcn67stj	273	15	the	the	DT
cord-354050-kcn67stj	273	16	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	273	17	promoter	promoter	NN
cord-354050-kcn67stj	273	18	is	be	VBZ
cord-354050-kcn67stj	273	19	associated	associate	VBN
cord-354050-kcn67stj	273	20	with	with	IN
cord-354050-kcn67stj	273	21	risk	risk	NN
cord-354050-kcn67stj	273	22	of	of	IN
cord-354050-kcn67stj	273	23	severe	severe	JJ
cord-354050-kcn67stj	273	24	influenza	influenza	NN
cord-354050-kcn67stj	273	25	in	in	IN
cord-354050-kcn67stj	273	26	humans	human	NNS
cord-354050-kcn67stj	274	1	The	the	DT
cord-354050-kcn67stj	274	2	small	small	JJ
cord-354050-kcn67stj	274	3	interferon	interferon	NN
cord-354050-kcn67stj	274	4	-	-	HYPH
cord-354050-kcn67stj	274	5	induced	induce	VBN
cord-354050-kcn67stj	274	6	transmembrane	transmembrane	NN
cord-354050-kcn67stj	274	7	genes	gene	NNS
cord-354050-kcn67stj	274	8	and	and	CC
cord-354050-kcn67stj	274	9	proteins	protein	NNS
cord-354050-kcn67stj	274	10	Age	age	NN
cord-354050-kcn67stj	274	11	-	-	HYPH
cord-354050-kcn67stj	274	12	related	relate	VBN
cord-354050-kcn67stj	274	13	onset	onset	NN
cord-354050-kcn67stj	274	14	of	of	IN
cord-354050-kcn67stj	274	15	obesity	obesity	NN
cord-354050-kcn67stj	274	16	corresponds	correspond	VBZ
cord-354050-kcn67stj	274	17	with	with	IN
cord-354050-kcn67stj	274	18	metabolic	metabolic	JJ
cord-354050-kcn67stj	274	19	dysregulation	dysregulation	NN
cord-354050-kcn67stj	274	20	and	and	CC
cord-354050-kcn67stj	274	21	altered	alter	VBN
cord-354050-kcn67stj	274	22	microglia	microglia	JJ
cord-354050-kcn67stj	274	23	morphology	morphology	NN
cord-354050-kcn67stj	274	24	in	in	IN
cord-354050-kcn67stj	274	25	mice	mouse	NNS
cord-354050-kcn67stj	274	26	deficient	deficient	JJ
cord-354050-kcn67stj	274	27	for	for	IN
cord-354050-kcn67stj	274	28	Ifitm	Ifitm	NNP
cord-354050-kcn67stj	274	29	proteins	protein	NNS
cord-354050-kcn67stj	275	1	IGF1	IGF1	NNP
cord-354050-kcn67stj	275	2	/	/	SYM
cord-354050-kcn67stj	275	3	IGF1R	IGF1R	NNP
cord-354050-kcn67stj	275	4	/	/	SYM
cord-354050-kcn67stj	275	5	STAT3	STAT3	NNP
cord-354050-kcn67stj	275	6	signaling	signal	VBG
cord-354050-kcn67stj	275	7	-	-	HYPH
cord-354050-kcn67stj	275	8	inducible	inducible	JJ
cord-354050-kcn67stj	276	1	IFITM2	IFITM2	NNP
cord-354050-kcn67stj	276	2	promotes	promote	VBZ
cord-354050-kcn67stj	276	3	gastric	gastric	JJ
cord-354050-kcn67stj	276	4	cancer	cancer	NN
cord-354050-kcn67stj	276	5	growth	growth	NN
cord-354050-kcn67stj	276	6	and	and	CC
cord-354050-kcn67stj	276	7	metastasis	metastasis	NN
cord-354050-kcn67stj	276	8	Mechanism	mechanism	NN
cord-354050-kcn67stj	276	9	and	and	CC
cord-354050-kcn67stj	276	10	biological	biological	JJ
cord-354050-kcn67stj	276	11	significance	significance	NN
cord-354050-kcn67stj	276	12	of	of	IN
cord-354050-kcn67stj	276	13	the	the	DT
cord-354050-kcn67stj	276	14	overexpression	overexpression	NN
cord-354050-kcn67stj	276	15	of	of	IN
cord-354050-kcn67stj	276	16	IFITM3	ifitm3	PRP
cord-354050-kcn67stj	276	17	in	in	IN
cord-354050-kcn67stj	276	18	gastric	gastric	JJ
cord-354050-kcn67stj	276	19	cancer	cancer	NN
cord-354050-kcn67stj	277	1	Interferon	interferon	NN
cord-354050-kcn67stj	277	2	-	-	HYPH
cord-354050-kcn67stj	277	3	induced	induce	VBN
cord-354050-kcn67stj	277	4	transmembrane	transmembrane	NN
cord-354050-kcn67stj	277	5	3	3	CD
cord-354050-kcn67stj	277	6	binds	bind	VBZ
cord-354050-kcn67stj	277	7	osteopontin	osteopontin	NNP
cord-354050-kcn67stj	277	8	in	in	IN
cord-354050-kcn67stj	277	9	vitro	vitro	FW
cord-354050-kcn67stj	277	10	:	:	:
cord-354050-kcn67stj	277	11	expressed	express	VBN
cord-354050-kcn67stj	277	12	in	in	IN
cord-354050-kcn67stj	277	13	vivo	vivo	NNP
cord-354050-kcn67stj	277	14	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	277	15	reduced	reduce	VBN
cord-354050-kcn67stj	277	16	OPN	OPN	NNP
cord-354050-kcn67stj	277	17	expression	expression	NN
cord-354050-kcn67stj	277	18	Ambra1	Ambra1	NNP
cord-354050-kcn67stj	277	19	spatially	spatially	RB
cord-354050-kcn67stj	277	20	regulates	regulate	VBZ
cord-354050-kcn67stj	277	21	Src	Src	NNP
cord-354050-kcn67stj	277	22	activity	activity	NN
cord-354050-kcn67stj	277	23	and	and	CC
cord-354050-kcn67stj	277	24	Src	Src	NNP
cord-354050-kcn67stj	277	25	/	/	SYM
cord-354050-kcn67stj	277	26	FAK	FAK	NNP
cord-354050-kcn67stj	277	27	-	-	HYPH
cord-354050-kcn67stj	277	28	mediated	mediate	VBN
cord-354050-kcn67stj	277	29	cancer	cancer	NN
cord-354050-kcn67stj	277	30	cell	cell	NN
cord-354050-kcn67stj	277	31	invasion	invasion	NN
cord-354050-kcn67stj	277	32	via	via	IN
cord-354050-kcn67stj	277	33	trafficking	trafficking	NN
cord-354050-kcn67stj	277	34	networks	network	NNS
cord-354050-kcn67stj	278	1	BAG3	BAG3	NNP
cord-354050-kcn67stj	278	2	promotes	promote	VBZ
cord-354050-kcn67stj	278	3	pancreatic	pancreatic	JJ
cord-354050-kcn67stj	278	4	ductal	ductal	JJ
cord-354050-kcn67stj	278	5	adenocarcinoma	adenocarcinoma	NN
cord-354050-kcn67stj	278	6	growth	growth	NN
cord-354050-kcn67stj	278	7	by	by	IN
cord-354050-kcn67stj	278	8	activating	activate	VBG
cord-354050-kcn67stj	278	9	stromal	stromal	JJ
cord-354050-kcn67stj	278	10	macrophages	macrophage	NNS
cord-354050-kcn67stj	279	1	Interferon	interferon	NN
cord-354050-kcn67stj	279	2	-	-	HYPH
cord-354050-kcn67stj	279	3	inducible	inducible	JJ
cord-354050-kcn67stj	279	4	transmembrane	transmembrane	NN
cord-354050-kcn67stj	279	5	proteins	protein	NNS
cord-354050-kcn67stj	279	6	of	of	IN
cord-354050-kcn67stj	279	7	the	the	DT
cord-354050-kcn67stj	279	8	innate	innate	JJ
cord-354050-kcn67stj	279	9	immune	immune	JJ
cord-354050-kcn67stj	279	10	response	response	NN
cord-354050-kcn67stj	279	11	act	act	NN
cord-354050-kcn67stj	279	12	as	as	IN
cord-354050-kcn67stj	279	13	membrane	membrane	NN
cord-354050-kcn67stj	279	14	organizers	organizer	NNS
cord-354050-kcn67stj	279	15	by	by	IN
cord-354050-kcn67stj	279	16	influencing	influence	VBG
cord-354050-kcn67stj	279	17	clathrin	clathrin	NN
cord-354050-kcn67stj	279	18	and	and	CC
cord-354050-kcn67stj	279	19	v	v	LS
cord-354050-kcn67stj	279	20	-	-	HYPH
cord-354050-kcn67stj	279	21	ATPase	atpase	NN
cord-354050-kcn67stj	279	22	localization	localization	NN
cord-354050-kcn67stj	279	23	and	and	CC
cord-354050-kcn67stj	279	24	function	function	NN
cord-354050-kcn67stj	280	1	Astroglial	Astroglial	NNP
cord-354050-kcn67stj	280	2	IFITM3	IFITM3	NNP
cord-354050-kcn67stj	280	3	mediates	mediate	VBZ
cord-354050-kcn67stj	280	4	neuronal	neuronal	JJ
cord-354050-kcn67stj	280	5	impairments	impairment	NNS
cord-354050-kcn67stj	280	6	following	follow	VBG
cord-354050-kcn67stj	280	7	neonatal	neonatal	JJ
cord-354050-kcn67stj	280	8	immune	immune	JJ
cord-354050-kcn67stj	280	9	challenge	challenge	NN
cord-354050-kcn67stj	280	10	in	in	IN
cord-354050-kcn67stj	280	11	mice	mouse	NNS
cord-354050-kcn67stj	280	12	Binding	Binding	NNP
cord-354050-kcn67stj	280	13	of	of	IN
cord-354050-kcn67stj	280	14	IFITM1	IFITM1	NNP
cord-354050-kcn67stj	280	15	enhances	enhance	VBZ
cord-354050-kcn67stj	280	16	the	the	DT
cord-354050-kcn67stj	280	17	inhibiting	inhibit	VBG
cord-354050-kcn67stj	280	18	effect	effect	NN
cord-354050-kcn67stj	280	19	of	of	IN
cord-354050-kcn67stj	280	20	caveolin-1	caveolin-1	NNP
cord-354050-kcn67stj	280	21	on	on	IN
cord-354050-kcn67stj	280	22	ERK	ERK	NNP
cord-354050-kcn67stj	280	23	activation	activation	NN
cord-354050-kcn67stj	281	1	IFITM1	IFITM1	NNP
cord-354050-kcn67stj	281	2	promotes	promote	VBZ
cord-354050-kcn67stj	281	3	the	the	DT
cord-354050-kcn67stj	281	4	metastasis	metastasis	NN
cord-354050-kcn67stj	281	5	of	of	IN
cord-354050-kcn67stj	281	6	human	human	JJ
cord-354050-kcn67stj	281	7	colorectal	colorectal	JJ
cord-354050-kcn67stj	281	8	cancer	cancer	NN
cord-354050-kcn67stj	281	9	via	via	IN
cord-354050-kcn67stj	281	10	CAV-1	CAV-1	NNP
cord-354050-kcn67stj	282	1	We	-PRON-	PRP
cord-354050-kcn67stj	282	2	thank	thank	VBP
cord-354050-kcn67stj	282	3	the	the	DT
cord-354050-kcn67stj	282	4	late	late	JJ
cord-354050-kcn67stj	282	5	Mark	Mark	NNP
cord-354050-kcn67stj	282	6	Wainberg	Wainberg	NNP
cord-354050-kcn67stj	282	7	for	for	IN
cord-354050-kcn67stj	282	8	his	-PRON-	PRP$
cord-354050-kcn67stj	282	9	support	support	NN
cord-354050-kcn67stj	282	10	and	and	CC
cord-354050-kcn67stj	282	11	for	for	IN
cord-354050-kcn67stj	282	12	his	-PRON-	PRP$
cord-354050-kcn67stj	282	13	efforts	effort	NNS
cord-354050-kcn67stj	282	14	at	at	IN
cord-354050-kcn67stj	282	15	the	the	DT
cord-354050-kcn67stj	282	16	Retrovirology	Retrovirology	NNP
cord-354050-kcn67stj	282	17	journal	journal	NN
cord-354050-kcn67stj	282	18	.	.	.
cord-354050-kcn67stj	283	1	OS	OS	NNP
cord-354050-kcn67stj	283	2	and	and	CC
cord-354050-kcn67stj	283	3	AAC	AAC	NNP
cord-354050-kcn67stj	283	4	conceived	conceive	VBD
cord-354050-kcn67stj	283	5	the	the	DT
cord-354050-kcn67stj	283	6	manuscript	manuscript	NN
cord-354050-kcn67stj	283	7	.	.	.
cord-354050-kcn67stj	284	1	GS	GS	NNP
cord-354050-kcn67stj	284	2	OS	OS	NNP
cord-354050-kcn67stj	284	3	and	and	CC
cord-354050-kcn67stj	284	4	AAC	AAC	NNP
cord-354050-kcn67stj	284	5	wrote	write	VBD
cord-354050-kcn67stj	284	6	and	and	CC
cord-354050-kcn67stj	284	7	edited	edit	VBD
cord-354050-kcn67stj	284	8	the	the	DT
cord-354050-kcn67stj	284	9	manuscript	manuscript	NN
cord-354050-kcn67stj	284	10	.	.	.
cord-354050-kcn67stj	285	1	All	all	DT
cord-354050-kcn67stj	285	2	authors	author	NNS
cord-354050-kcn67stj	285	3	read	read	VBP
cord-354050-kcn67stj	285	4	and	and	CC
cord-354050-kcn67stj	285	5	approved	approve	VBD
cord-354050-kcn67stj	285	6	the	the	DT
cord-354050-kcn67stj	285	7	final	final	JJ
cord-354050-kcn67stj	285	8	manuscript	manuscript	NN
cord-354050-kcn67stj	285	9	.	.	.
cord-354050-kcn67stj	285	10	 	 	_SP
cord-354050-kcn67stj	286	1	The	the	DT
cord-354050-kcn67stj	286	2	authors	author	NNS
cord-354050-kcn67stj	286	3	hereby	hereby	RB
cord-354050-kcn67stj	286	4	state	state	VBP
cord-354050-kcn67stj	286	5	that	that	IN
cord-354050-kcn67stj	286	6	no	no	DT
cord-354050-kcn67stj	286	7	competing	compete	VBG
cord-354050-kcn67stj	286	8	interests	interest	NNS
cord-354050-kcn67stj	286	9	exist	exist	VBP
cord-354050-kcn67stj	286	10	.	.	.
cord-354050-kcn67stj	287	1	Not	not	RB
cord-354050-kcn67stj	287	2	applicable	applicable	JJ
cord-354050-kcn67stj	287	3	.	.	.
cord-354050-kcn67stj	288	1	All	all	DT
cord-354050-kcn67stj	288	2	authors	author	NNS
cord-354050-kcn67stj	288	3	consent	consent	VBP
cord-354050-kcn67stj	288	4	to	to	IN
cord-354050-kcn67stj	288	5	the	the	DT
cord-354050-kcn67stj	288	6	publication	publication	NN
cord-354050-kcn67stj	288	7	of	of	IN
cord-354050-kcn67stj	288	8	this	this	DT
cord-354050-kcn67stj	288	9	manuscript	manuscript	NN
cord-354050-kcn67stj	288	10	.	.	.
cord-354050-kcn67stj	289	1	Not	not	RB
cord-354050-kcn67stj	289	2	applicable	applicable	JJ
cord-354050-kcn67stj	289	3	.	.	.
cord-354050-kcn67stj	290	1	Work	work	VB
cord-354050-kcn67stj	290	2	in	in	IN
cord-354050-kcn67stj	290	3	the	the	DT
cord-354050-kcn67stj	290	4	lab	lab	NN
cord-354050-kcn67stj	290	5	of	of	IN
cord-354050-kcn67stj	290	6	AAC	AAC	NNP
cord-354050-kcn67stj	290	7	is	be	VBZ
cord-354050-kcn67stj	290	8	supported	support	VBN
cord-354050-kcn67stj	290	9	by	by	IN
cord-354050-kcn67stj	290	10	the	the	DT
cord-354050-kcn67stj	290	11	Intramural	Intramural	NNP
cord-354050-kcn67stj	290	12	Research	Research	NNP
cord-354050-kcn67stj	290	13	Program	Program	NNP
cord-354050-kcn67stj	290	14	of	of	IN
cord-354050-kcn67stj	290	15	the	the	DT
cord-354050-kcn67stj	290	16	NIH	NIH	NNP
cord-354050-kcn67stj	290	17	,	,	,
cord-354050-kcn67stj	290	18	National	National	NNP
cord-354050-kcn67stj	290	19	Cancer	Cancer	NNP
cord-354050-kcn67stj	290	20	Institute	Institute	NNP
cord-354050-kcn67stj	290	21	,	,	,
cord-354050-kcn67stj	290	22	Center	Center	NNP
cord-354050-kcn67stj	290	23	for	for	IN
cord-354050-kcn67stj	290	24	Cancer	Cancer	NNP
cord-354050-kcn67stj	290	25	Research	Research	NNP
cord-354050-kcn67stj	290	26	.	.	.
cord-354050-kcn67stj	291	1	Work	work	VB
cord-354050-kcn67stj	291	2	in	in	IN
cord-354050-kcn67stj	291	3	the	the	DT
cord-354050-kcn67stj	291	4	lab	lab	NN
cord-354050-kcn67stj	291	5	of	of	IN
cord-354050-kcn67stj	291	6	OS	OS	NNP
cord-354050-kcn67stj	291	7	is	be	VBZ
cord-354050-kcn67stj	291	8	supported	support	VBN
cord-354050-kcn67stj	291	9	by	by	IN
cord-354050-kcn67stj	291	10	grants	grant	NNS
cord-354050-kcn67stj	291	11	from	from	IN
cord-354050-kcn67stj	291	12	the	the	DT
cord-354050-kcn67stj	291	13	ANRS	ANRS	NNP
cord-354050-kcn67stj	291	14	,	,	,
cord-354050-kcn67stj	291	15	the	the	DT
cord-354050-kcn67stj	291	16	Vaccine	Vaccine	NNP
cord-354050-kcn67stj	291	17	Research	Research	NNP
cord-354050-kcn67stj	291	18	Institute	Institute	NNP
cord-354050-kcn67stj	291	19	,	,	,
cord-354050-kcn67stj	291	20	the	the	DT
cord-354050-kcn67stj	291	21	"	"	``
cord-354050-kcn67stj	291	22	CHIKV	CHIKV	NNP
cord-354050-kcn67stj	291	23	-	-	HYPH
cord-354050-kcn67stj	291	24	Viro	Viro	NNP
cord-354050-kcn67stj	291	25	-	-	HYPH
cord-354050-kcn67stj	291	26	Immuno	Immuno	NNP
cord-354050-kcn67stj	291	27	"	"	''
cord-354050-kcn67stj	291	28	ANR-14-CE14	anr-14-ce14	NN
cord-354050-kcn67stj	291	29	-	-	HYPH
cord-354050-kcn67stj	291	30	0015	0015	CD
cord-354050-kcn67stj	291	31	-	-	HYPH
cord-354050-kcn67stj	291	32	01	01	CD
cord-354050-kcn67stj	291	33	and	and	CC
cord-354050-kcn67stj	291	34	"	"	``
cord-354050-kcn67stj	291	35	TIMTAMDEN	TIMTAMDEN	NNP
cord-354050-kcn67stj	291	36	"	"	''
cord-354050-kcn67stj	291	37	ANR-14-CE14	anr-14-ce14	NN
cord-354050-kcn67stj	291	38	-	-	HYPH
cord-354050-kcn67stj	291	39	0029	0029	CD
cord-354050-kcn67stj	291	40	projects	project	NNS
cord-354050-kcn67stj	291	41	,	,	,
cord-354050-kcn67stj	291	42	the	the	DT
cord-354050-kcn67stj	291	43	Labex	Labex	NNP
cord-354050-kcn67stj	291	44	IBEID	IBEID	NNP
cord-354050-kcn67stj	291	45	program	program	NN
cord-354050-kcn67stj	291	46	ANR-10-IHUB-0002	ANR-10-IHUB-0002	NNP
cord-354050-kcn67stj	291	47	,	,	,
cord-354050-kcn67stj	291	48	a	a	DT
cord-354050-kcn67stj	291	49	Gilead	Gilead	NNP
cord-354050-kcn67stj	291	50	HIV	HIV	NNP
cord-354050-kcn67stj	291	51	Cure	Cure	NNP
cord-354050-kcn67stj	291	52	Grant	Grant	NNP
cord-354050-kcn67stj	291	53	and	and	CC
cord-354050-kcn67stj	291	54	Institut	Institut	NNP
cord-354050-kcn67stj	291	55	Pasteur	Pasteur	NNP
cord-354050-kcn67stj	291	56	.	.	.
cord-354050-kcn67stj	292	1	Springer	Springer	NNP
cord-354050-kcn67stj	292	2	Nature	Nature	NNP
cord-354050-kcn67stj	292	3	remains	remain	VBZ
cord-354050-kcn67stj	292	4	neutral	neutral	JJ
cord-354050-kcn67stj	292	5	with	with	IN
cord-354050-kcn67stj	292	6	regard	regard	NN
cord-354050-kcn67stj	292	7	to	to	IN
cord-354050-kcn67stj	292	8	jurisdictional	jurisdictional	JJ
cord-354050-kcn67stj	292	9	claims	claim	NNS
cord-354050-kcn67stj	292	10	in	in	IN
cord-354050-kcn67stj	292	11	published	publish	VBN
cord-354050-kcn67stj	292	12	maps	map	NNS
cord-354050-kcn67stj	292	13	and	and	CC
cord-354050-kcn67stj	292	14	institutional	institutional	JJ
cord-354050-kcn67stj	292	15	affiliations	affiliation	NNS
cord-354050-kcn67stj	292	16	.	.	.
cord-354050-kcn67stj	292	17	 	 	_SP