id sid tid token lemma pos cord-354029-mp5r82g4 1 1 key key NN cord-354029-mp5r82g4 1 2 : : : cord-354029-mp5r82g4 1 3 cord-354029-mp5r82g4 cord-354029-mp5r82g4 NNP cord-354029-mp5r82g4 1 4 authors author NNS cord-354029-mp5r82g4 1 5 : : : cord-354029-mp5r82g4 1 6 Earp Earp NNP cord-354029-mp5r82g4 1 7 , , , cord-354029-mp5r82g4 1 8 L. L. NNP cord-354029-mp5r82g4 1 9 J. J. NNP cord-354029-mp5r82g4 1 10 ; ; : cord-354029-mp5r82g4 1 11 Delos Delos NNP cord-354029-mp5r82g4 1 12 , , , cord-354029-mp5r82g4 1 13 S. S. NNP cord-354029-mp5r82g4 1 14 E. E. NNP cord-354029-mp5r82g4 1 15 ; ; : cord-354029-mp5r82g4 1 16 Park Park NNP cord-354029-mp5r82g4 1 17 , , , cord-354029-mp5r82g4 1 18 H. H. NNP cord-354029-mp5r82g4 1 19 E. E. NNP cord-354029-mp5r82g4 1 20 ; ; : cord-354029-mp5r82g4 1 21 White White NNP cord-354029-mp5r82g4 1 22 , , , cord-354029-mp5r82g4 1 23 J. J. NNP cord-354029-mp5r82g4 1 24 M. M. NNP cord-354029-mp5r82g4 2 1 title title NN cord-354029-mp5r82g4 2 2 : : : cord-354029-mp5r82g4 3 1 The the DT cord-354029-mp5r82g4 3 2 Many many JJ cord-354029-mp5r82g4 3 3 Mechanisms Mechanisms NNPS cord-354029-mp5r82g4 3 4 of of IN cord-354029-mp5r82g4 3 5 Viral Viral NNP cord-354029-mp5r82g4 3 6 Membrane Membrane NNP cord-354029-mp5r82g4 3 7 Fusion Fusion NNP cord-354029-mp5r82g4 3 8 Proteins protein NNS cord-354029-mp5r82g4 3 9 date date NN cord-354029-mp5r82g4 3 10 : : : cord-354029-mp5r82g4 3 11 2005 2005 CD cord-354029-mp5r82g4 3 12 journal journal NN cord-354029-mp5r82g4 3 13 : : : cord-354029-mp5r82g4 4 1 Membrane membrane NN cord-354029-mp5r82g4 4 2 Trafficking traffic VBG cord-354029-mp5r82g4 4 3 in in IN cord-354029-mp5r82g4 4 4 Viral viral JJ cord-354029-mp5r82g4 4 5 Replication replication NN cord-354029-mp5r82g4 4 6 DOI doi NN cord-354029-mp5r82g4 4 7 : : : cord-354029-mp5r82g4 5 1 10.1007/3 10.1007/3 CD cord-354029-mp5r82g4 5 2 - - HYPH cord-354029-mp5r82g4 5 3 540 540 CD cord-354029-mp5r82g4 5 4 - - HYPH cord-354029-mp5r82g4 5 5 26764 26764 CD cord-354029-mp5r82g4 5 6 - - HYPH cord-354029-mp5r82g4 5 7 6_2 6_2 CD cord-354029-mp5r82g4 6 1 sha sha NNP cord-354029-mp5r82g4 6 2 : : : cord-354029-mp5r82g4 7 1 fec68be172892ad208b7d73c0e5c249c2ea3c3e6 fec68be172892ad208b7d73c0e5c249c2ea3c3e6 NNP cord-354029-mp5r82g4 7 2 doc_id doc_id NNP cord-354029-mp5r82g4 7 3 : : : cord-354029-mp5r82g4 7 4 354029 354029 CD cord-354029-mp5r82g4 7 5 cord_uid cord_uid NNS cord-354029-mp5r82g4 7 6 : : : cord-354029-mp5r82g4 7 7 mp5r82g4 mp5r82g4 NNP cord-354029-mp5r82g4 8 1 Every every DT cord-354029-mp5r82g4 8 2 enveloped envelop VBN cord-354029-mp5r82g4 8 3 virus virus NN cord-354029-mp5r82g4 8 4 fuses fuse VBZ cord-354029-mp5r82g4 8 5 its -PRON- PRP$ cord-354029-mp5r82g4 8 6 membrane membrane NN cord-354029-mp5r82g4 8 7 with with IN cord-354029-mp5r82g4 8 8 a a DT cord-354029-mp5r82g4 8 9 host host NN cord-354029-mp5r82g4 8 10 cell cell NN cord-354029-mp5r82g4 8 11 membrane membrane NN cord-354029-mp5r82g4 8 12 , , , cord-354029-mp5r82g4 8 13 thereby thereby RB cord-354029-mp5r82g4 8 14 releasing release VBG cord-354029-mp5r82g4 8 15 its -PRON- PRP$ cord-354029-mp5r82g4 8 16 genome genome NN cord-354029-mp5r82g4 8 17 into into IN cord-354029-mp5r82g4 8 18 the the DT cord-354029-mp5r82g4 8 19 cytoplasm cytoplasm NN cord-354029-mp5r82g4 8 20 and and CC cord-354029-mp5r82g4 8 21 initiating initiate VBG cord-354029-mp5r82g4 8 22 the the DT cord-354029-mp5r82g4 8 23 viral viral JJ cord-354029-mp5r82g4 8 24 replication replication NN cord-354029-mp5r82g4 8 25 cycle cycle NN cord-354029-mp5r82g4 8 26 . . . cord-354029-mp5r82g4 9 1 In in IN cord-354029-mp5r82g4 9 2 each each DT cord-354029-mp5r82g4 9 3 case case NN cord-354029-mp5r82g4 9 4 , , , cord-354029-mp5r82g4 9 5 one one CD cord-354029-mp5r82g4 9 6 or or CC cord-354029-mp5r82g4 9 7 a a DT cord-354029-mp5r82g4 9 8 small small JJ cord-354029-mp5r82g4 9 9 set set NN cord-354029-mp5r82g4 9 10 of of IN cord-354029-mp5r82g4 9 11 viral viral JJ cord-354029-mp5r82g4 9 12 surface surface NN cord-354029-mp5r82g4 9 13 transmembrane transmembrane NN cord-354029-mp5r82g4 9 14 glycoproteins glycoprotein NNS cord-354029-mp5r82g4 9 15 mediates mediate VBZ cord-354029-mp5r82g4 9 16 fusion fusion NN cord-354029-mp5r82g4 9 17 . . . cord-354029-mp5r82g4 10 1 Viral viral JJ cord-354029-mp5r82g4 10 2 fusion fusion NN cord-354029-mp5r82g4 10 3 proteins protein NNS cord-354029-mp5r82g4 10 4 vary vary VBP cord-354029-mp5r82g4 10 5 in in IN cord-354029-mp5r82g4 10 6 their -PRON- PRP$ cord-354029-mp5r82g4 10 7 mode mode NN cord-354029-mp5r82g4 10 8 of of IN cord-354029-mp5r82g4 10 9 activation activation NN cord-354029-mp5r82g4 10 10 and and CC cord-354029-mp5r82g4 10 11 in in IN cord-354029-mp5r82g4 10 12 structural structural JJ cord-354029-mp5r82g4 10 13 class class NN cord-354029-mp5r82g4 10 14 . . . cord-354029-mp5r82g4 11 1 These these DT cord-354029-mp5r82g4 11 2 features feature NNS cord-354029-mp5r82g4 11 3 combine combine VBP cord-354029-mp5r82g4 11 4 to to TO cord-354029-mp5r82g4 11 5 yield yield VB cord-354029-mp5r82g4 11 6 many many JJ cord-354029-mp5r82g4 11 7 different different JJ cord-354029-mp5r82g4 11 8 fusion fusion NN cord-354029-mp5r82g4 11 9 mechanisms mechanism NNS cord-354029-mp5r82g4 11 10 . . . cord-354029-mp5r82g4 12 1 Despite despite IN cord-354029-mp5r82g4 12 2 their -PRON- PRP$ cord-354029-mp5r82g4 12 3 differences difference NNS cord-354029-mp5r82g4 12 4 , , , cord-354029-mp5r82g4 12 5 common common JJ cord-354029-mp5r82g4 12 6 principles principle NNS cord-354029-mp5r82g4 12 7 for for IN cord-354029-mp5r82g4 12 8 how how WRB cord-354029-mp5r82g4 12 9 fusion fusion NN cord-354029-mp5r82g4 12 10 proteins protein NNS cord-354029-mp5r82g4 12 11 function function NN cord-354029-mp5r82g4 12 12 are be VBP cord-354029-mp5r82g4 12 13 emerging emerge VBG cord-354029-mp5r82g4 12 14 : : : cord-354029-mp5r82g4 12 15 In in IN cord-354029-mp5r82g4 12 16 response response NN cord-354029-mp5r82g4 12 17 to to IN cord-354029-mp5r82g4 12 18 an an DT cord-354029-mp5r82g4 12 19 activating activate VBG cord-354029-mp5r82g4 12 20 trigger trigger NN cord-354029-mp5r82g4 12 21 , , , cord-354029-mp5r82g4 12 22 the the DT cord-354029-mp5r82g4 12 23 metastable metastable JJ cord-354029-mp5r82g4 12 24 fusion fusion NN cord-354029-mp5r82g4 12 25 protein protein NN cord-354029-mp5r82g4 12 26 converts convert VBZ cord-354029-mp5r82g4 12 27 to to IN cord-354029-mp5r82g4 12 28 an an DT cord-354029-mp5r82g4 12 29 extended extended JJ cord-354029-mp5r82g4 12 30 , , , cord-354029-mp5r82g4 12 31 in in IN cord-354029-mp5r82g4 12 32 some some DT cord-354029-mp5r82g4 12 33 cases case NNS cord-354029-mp5r82g4 12 34 rodlike rodlike JJ cord-354029-mp5r82g4 12 35 structure structure NN cord-354029-mp5r82g4 12 36 , , , cord-354029-mp5r82g4 12 37 which which WDT cord-354029-mp5r82g4 12 38 inserts insert VBZ cord-354029-mp5r82g4 12 39 into into IN cord-354029-mp5r82g4 12 40 the the DT cord-354029-mp5r82g4 12 41 target target NN cord-354029-mp5r82g4 12 42 membrane membrane NN cord-354029-mp5r82g4 12 43 via via IN cord-354029-mp5r82g4 12 44 its -PRON- PRP$ cord-354029-mp5r82g4 12 45 fusion fusion NN cord-354029-mp5r82g4 12 46 peptide peptide NN cord-354029-mp5r82g4 12 47 . . . cord-354029-mp5r82g4 13 1 A a DT cord-354029-mp5r82g4 13 2 subsequent subsequent JJ cord-354029-mp5r82g4 13 3 conformational conformational JJ cord-354029-mp5r82g4 13 4 change change NN cord-354029-mp5r82g4 13 5 causes cause VBZ cord-354029-mp5r82g4 13 6 the the DT cord-354029-mp5r82g4 13 7 fusion fusion NN cord-354029-mp5r82g4 13 8 protein protein NN cord-354029-mp5r82g4 13 9 to to TO cord-354029-mp5r82g4 13 10 fold fold VB cord-354029-mp5r82g4 13 11 back back RB cord-354029-mp5r82g4 13 12 upon upon IN cord-354029-mp5r82g4 13 13 itself -PRON- PRP cord-354029-mp5r82g4 13 14 , , , cord-354029-mp5r82g4 13 15 thereby thereby RB cord-354029-mp5r82g4 13 16 bringing bring VBG cord-354029-mp5r82g4 13 17 its -PRON- PRP$ cord-354029-mp5r82g4 13 18 fusion fusion NN cord-354029-mp5r82g4 13 19 peptide peptide NN cord-354029-mp5r82g4 13 20 and and CC cord-354029-mp5r82g4 13 21 its -PRON- PRP$ cord-354029-mp5r82g4 13 22 transmembrane transmembrane NN cord-354029-mp5r82g4 13 23 domain domain NN cord-354029-mp5r82g4 13 24 — — : cord-354029-mp5r82g4 13 25 and and CC cord-354029-mp5r82g4 13 26 their -PRON- PRP$ cord-354029-mp5r82g4 13 27 attached attach VBN cord-354029-mp5r82g4 13 28 target target NN cord-354029-mp5r82g4 13 29 and and CC cord-354029-mp5r82g4 13 30 viral viral JJ cord-354029-mp5r82g4 13 31 membranes membrane NNS cord-354029-mp5r82g4 13 32 — — : cord-354029-mp5r82g4 13 33 into into IN cord-354029-mp5r82g4 13 34 intimate intimate JJ cord-354029-mp5r82g4 13 35 contact contact NN cord-354029-mp5r82g4 13 36 . . . cord-354029-mp5r82g4 14 1 Fusion fusion NN cord-354029-mp5r82g4 14 2 ensues ensue VBZ cord-354029-mp5r82g4 14 3 as as IN cord-354029-mp5r82g4 14 4 the the DT cord-354029-mp5r82g4 14 5 initial initial JJ cord-354029-mp5r82g4 14 6 lipid lipid NN cord-354029-mp5r82g4 14 7 stalk stalk NN cord-354029-mp5r82g4 14 8 progresses progress VBZ cord-354029-mp5r82g4 14 9 through through IN cord-354029-mp5r82g4 14 10 local local JJ cord-354029-mp5r82g4 14 11 hemifusion hemifusion NN cord-354029-mp5r82g4 14 12 , , , cord-354029-mp5r82g4 14 13 and and CC cord-354029-mp5r82g4 14 14 then then RB cord-354029-mp5r82g4 14 15 opening opening NN cord-354029-mp5r82g4 14 16 and and CC cord-354029-mp5r82g4 14 17 enlargement enlargement NN cord-354029-mp5r82g4 14 18 of of IN cord-354029-mp5r82g4 14 19 a a DT cord-354029-mp5r82g4 14 20 fusion fusion NN cord-354029-mp5r82g4 14 21 pore pore NN cord-354029-mp5r82g4 14 22 . . . cord-354029-mp5r82g4 15 1 Here here RB cord-354029-mp5r82g4 15 2 we -PRON- PRP cord-354029-mp5r82g4 15 3 review review VBP cord-354029-mp5r82g4 15 4 recent recent JJ cord-354029-mp5r82g4 15 5 advances advance NNS cord-354029-mp5r82g4 15 6 in in IN cord-354029-mp5r82g4 15 7 our -PRON- PRP$ cord-354029-mp5r82g4 15 8 understanding understanding NN cord-354029-mp5r82g4 15 9 of of IN cord-354029-mp5r82g4 15 10 how how WRB cord-354029-mp5r82g4 15 11 fusion fusion NN cord-354029-mp5r82g4 15 12 proteins protein NNS cord-354029-mp5r82g4 15 13 are be VBP cord-354029-mp5r82g4 15 14 activated activate VBN cord-354029-mp5r82g4 15 15 , , , cord-354029-mp5r82g4 15 16 how how WRB cord-354029-mp5r82g4 15 17 fusion fusion NN cord-354029-mp5r82g4 15 18 proteins protein NNS cord-354029-mp5r82g4 15 19 change change VBP cord-354029-mp5r82g4 15 20 conformation conformation NN cord-354029-mp5r82g4 15 21 during during IN cord-354029-mp5r82g4 15 22 fusion fusion NN cord-354029-mp5r82g4 15 23 , , , cord-354029-mp5r82g4 15 24 and and CC cord-354029-mp5r82g4 15 25 what what WP cord-354029-mp5r82g4 15 26 is be VBZ cord-354029-mp5r82g4 15 27 happening happen VBG cord-354029-mp5r82g4 15 28 to to IN cord-354029-mp5r82g4 15 29 the the DT cord-354029-mp5r82g4 15 30 lipids lipid NNS cord-354029-mp5r82g4 15 31 during during IN cord-354029-mp5r82g4 15 32 fusion fusion NN cord-354029-mp5r82g4 15 33 . . . cord-354029-mp5r82g4 16 1 We -PRON- PRP cord-354029-mp5r82g4 16 2 also also RB cord-354029-mp5r82g4 16 3 briefly briefly RB cord-354029-mp5r82g4 16 4 discuss discuss VBP cord-354029-mp5r82g4 16 5 the the DT cord-354029-mp5r82g4 16 6 therapeutic therapeutic JJ cord-354029-mp5r82g4 16 7 potential potential NN cord-354029-mp5r82g4 16 8 of of IN cord-354029-mp5r82g4 16 9 fusion fusion NN cord-354029-mp5r82g4 16 10 inhibitors inhibitor NNS cord-354029-mp5r82g4 16 11 in in IN cord-354029-mp5r82g4 16 12 treating treat VBG cord-354029-mp5r82g4 16 13 viral viral JJ cord-354029-mp5r82g4 16 14 infections infection NNS cord-354029-mp5r82g4 16 15 . . . cord-354029-mp5r82g4 17 1 1 1 CD cord-354029-mp5r82g4 17 2 Introduction Introduction NNP cord-354029-mp5r82g4 17 3 Fusion Fusion NNP cord-354029-mp5r82g4 17 4 of of IN cord-354029-mp5r82g4 17 5 enveloped envelop VBN cord-354029-mp5r82g4 17 6 viruses virus NNS cord-354029-mp5r82g4 17 7 with with IN cord-354029-mp5r82g4 17 8 host host NN cord-354029-mp5r82g4 17 9 cells cell NNS cord-354029-mp5r82g4 17 10 remains remain VBZ cord-354029-mp5r82g4 17 11 an an DT cord-354029-mp5r82g4 17 12 important important JJ cord-354029-mp5r82g4 17 13 topic topic NN cord-354029-mp5r82g4 17 14 of of IN cord-354029-mp5r82g4 17 15 research research NN cord-354029-mp5r82g4 17 16 for for IN cord-354029-mp5r82g4 17 17 two two CD cord-354029-mp5r82g4 17 18 major major JJ cord-354029-mp5r82g4 17 19 reasons reason NNS cord-354029-mp5r82g4 17 20 . . . cord-354029-mp5r82g4 18 1 First first RB cord-354029-mp5r82g4 18 2 , , , cord-354029-mp5r82g4 18 3 it -PRON- PRP cord-354029-mp5r82g4 18 4 has have VBZ cord-354029-mp5r82g4 18 5 recently recently RB cord-354029-mp5r82g4 18 6 become become VBN cord-354029-mp5r82g4 18 7 clear clear JJ cord-354029-mp5r82g4 18 8 that that IN cord-354029-mp5r82g4 18 9 fusion fusion NN cord-354029-mp5r82g4 18 10 is be VBZ cord-354029-mp5r82g4 18 11 a a DT cord-354029-mp5r82g4 18 12 good good JJ cord-354029-mp5r82g4 18 13 target target NN cord-354029-mp5r82g4 18 14 for for IN cord-354029-mp5r82g4 18 15 therapeutic therapeutic JJ cord-354029-mp5r82g4 18 16 intervention intervention NN cord-354029-mp5r82g4 18 17 ( ( -LRB- cord-354029-mp5r82g4 18 18 Kilby Kilby NNP cord-354029-mp5r82g4 18 19 et et NNP cord-354029-mp5r82g4 18 20 al al NNP cord-354029-mp5r82g4 18 21 . . . cord-354029-mp5r82g4 18 22 1998 1998 CD cord-354029-mp5r82g4 18 23 ) ) -RRB- cord-354029-mp5r82g4 18 24 . . . cord-354029-mp5r82g4 19 1 Second second JJ cord-354029-mp5r82g4 19 2 , , , cord-354029-mp5r82g4 19 3 viral viral JJ cord-354029-mp5r82g4 19 4 fusion fusion NN cord-354029-mp5r82g4 19 5 reactions reaction NNS cord-354029-mp5r82g4 19 6 continue continue VBP cord-354029-mp5r82g4 19 7 to to TO cord-354029-mp5r82g4 19 8 serve serve VB cord-354029-mp5r82g4 19 9 as as IN cord-354029-mp5r82g4 19 10 models model NNS cord-354029-mp5r82g4 19 11 for for IN cord-354029-mp5r82g4 19 12 cellular cellular JJ cord-354029-mp5r82g4 19 13 fusion fusion NN cord-354029-mp5r82g4 19 14 events event NNS cord-354029-mp5r82g4 19 15 . . . cord-354029-mp5r82g4 20 1 Although although IN cord-354029-mp5r82g4 20 2 several several JJ cord-354029-mp5r82g4 20 3 viral viral JJ cord-354029-mp5r82g4 20 4 fusion fusion NN cord-354029-mp5r82g4 20 5 proteins protein NNS cord-354029-mp5r82g4 20 6 , , , cord-354029-mp5r82g4 20 7 such such JJ cord-354029-mp5r82g4 20 8 as as IN cord-354029-mp5r82g4 20 9 influenza influenza NN cord-354029-mp5r82g4 20 10 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 20 11 ( ( -LRB- cord-354029-mp5r82g4 20 12 HA HA NNP cord-354029-mp5r82g4 20 13 ) ) -RRB- cord-354029-mp5r82g4 20 14 and and CC cord-354029-mp5r82g4 20 15 the the DT cord-354029-mp5r82g4 20 16 human human JJ cord-354029-mp5r82g4 20 17 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 20 18 virus virus NN cord-354029-mp5r82g4 20 19 ( ( -LRB- cord-354029-mp5r82g4 20 20 HIV HIV NNP cord-354029-mp5r82g4 20 21 ) ) -RRB- cord-354029-mp5r82g4 20 22 envelope envelope NN cord-354029-mp5r82g4 20 23 glycoprotein glycoprotein NN cord-354029-mp5r82g4 20 24 ( ( -LRB- cord-354029-mp5r82g4 20 25 Env Env NNP cord-354029-mp5r82g4 20 26 ) ) -RRB- cord-354029-mp5r82g4 20 27 , , , cord-354029-mp5r82g4 20 28 have have VBP cord-354029-mp5r82g4 20 29 emerged emerge VBN cord-354029-mp5r82g4 20 30 as as IN cord-354029-mp5r82g4 20 31 paradigms paradigm NNS cord-354029-mp5r82g4 20 32 , , , cord-354029-mp5r82g4 20 33 it -PRON- PRP cord-354029-mp5r82g4 20 34 is be VBZ cord-354029-mp5r82g4 20 35 important important JJ cord-354029-mp5r82g4 20 36 to to TO cord-354029-mp5r82g4 20 37 realize realize VB cord-354029-mp5r82g4 20 38 that that IN cord-354029-mp5r82g4 20 39 there there EX cord-354029-mp5r82g4 20 40 are be VBP cord-354029-mp5r82g4 20 41 many many JJ cord-354029-mp5r82g4 20 42 distinguishing distinguish VBG cord-354029-mp5r82g4 20 43 features feature NNS cord-354029-mp5r82g4 20 44 among among IN cord-354029-mp5r82g4 20 45 viral viral JJ cord-354029-mp5r82g4 20 46 fusion fusion NN cord-354029-mp5r82g4 20 47 proteins protein NNS cord-354029-mp5r82g4 20 48 ( ( -LRB- cord-354029-mp5r82g4 20 49 Table table NN cord-354029-mp5r82g4 20 50 1 1 CD cord-354029-mp5r82g4 20 51 ) ) -RRB- cord-354029-mp5r82g4 20 52 . . . cord-354029-mp5r82g4 21 1 Viral viral JJ cord-354029-mp5r82g4 21 2 fusion fusion NN cord-354029-mp5r82g4 21 3 proteins protein NNS cord-354029-mp5r82g4 21 4 can can MD cord-354029-mp5r82g4 21 5 be be VB cord-354029-mp5r82g4 21 6 activated activate VBN cord-354029-mp5r82g4 21 7 for for IN cord-354029-mp5r82g4 21 8 fusion fusion NN cord-354029-mp5r82g4 21 9 by by IN cord-354029-mp5r82g4 21 10 different different JJ cord-354029-mp5r82g4 21 11 mechanisms mechanism NNS cord-354029-mp5r82g4 21 12 . . . cord-354029-mp5r82g4 22 1 They -PRON- PRP cord-354029-mp5r82g4 22 2 have have VBP cord-354029-mp5r82g4 22 3 also also RB cord-354029-mp5r82g4 22 4 been be VBN cord-354029-mp5r82g4 22 5 classified classify VBN cord-354029-mp5r82g4 22 6 according accord VBG cord-354029-mp5r82g4 22 7 to to IN cord-354029-mp5r82g4 22 8 structural structural JJ cord-354029-mp5r82g4 22 9 criteria criterion NNS cord-354029-mp5r82g4 22 10 . . . cord-354029-mp5r82g4 23 1 For for IN cord-354029-mp5r82g4 23 2 some some DT cord-354029-mp5r82g4 23 3 viruses virus NNS cord-354029-mp5r82g4 23 4 , , , cord-354029-mp5r82g4 23 5 the the DT cord-354029-mp5r82g4 23 6 viral viral JJ cord-354029-mp5r82g4 23 7 receptor receptor NN cord-354029-mp5r82g4 23 8 does do VBZ cord-354029-mp5r82g4 23 9 not not RB cord-354029-mp5r82g4 23 10 actively actively RB cord-354029-mp5r82g4 23 11 participate participate VB cord-354029-mp5r82g4 23 12 in in IN cord-354029-mp5r82g4 23 13 fusion fusion NN cord-354029-mp5r82g4 23 14 , , , cord-354029-mp5r82g4 23 15 whereas whereas IN cord-354029-mp5r82g4 23 16 for for IN cord-354029-mp5r82g4 23 17 others other NNS cord-354029-mp5r82g4 23 18 , , , cord-354029-mp5r82g4 23 19 one one CD cord-354029-mp5r82g4 23 20 or or CC cord-354029-mp5r82g4 23 21 more more JJR cord-354029-mp5r82g4 23 22 receptors receptor NNS cord-354029-mp5r82g4 23 23 are be VBP cord-354029-mp5r82g4 23 24 essential essential JJ cord-354029-mp5r82g4 23 25 players player NNS cord-354029-mp5r82g4 23 26 . . . cord-354029-mp5r82g4 24 1 The the DT cord-354029-mp5r82g4 24 2 location location NN cord-354029-mp5r82g4 24 3 of of IN cord-354029-mp5r82g4 24 4 the the DT cord-354029-mp5r82g4 24 5 fusion fusion NN cord-354029-mp5r82g4 24 6 peptide peptide NN cord-354029-mp5r82g4 24 7 , , , cord-354029-mp5r82g4 24 8 critical critical JJ cord-354029-mp5r82g4 24 9 for for IN cord-354029-mp5r82g4 24 10 fusion fusion NN cord-354029-mp5r82g4 24 11 , , , cord-354029-mp5r82g4 24 12 can can MD cord-354029-mp5r82g4 24 13 vary vary VB cord-354029-mp5r82g4 24 14 . . . cord-354029-mp5r82g4 25 1 Finally finally RB cord-354029-mp5r82g4 25 2 , , , cord-354029-mp5r82g4 25 3 whereas whereas IN cord-354029-mp5r82g4 25 4 some some DT cord-354029-mp5r82g4 25 5 viruses virus NNS cord-354029-mp5r82g4 25 6 require require VBP cord-354029-mp5r82g4 25 7 a a DT cord-354029-mp5r82g4 25 8 single single JJ cord-354029-mp5r82g4 25 9 viral viral JJ cord-354029-mp5r82g4 25 10 glycoprotein glycoprotein NN cord-354029-mp5r82g4 25 11 to to TO cord-354029-mp5r82g4 25 12 mediate mediate VB cord-354029-mp5r82g4 25 13 fusion fusion NN cord-354029-mp5r82g4 25 14 , , , cord-354029-mp5r82g4 25 15 others other NNS cord-354029-mp5r82g4 25 16 require require VBP cord-354029-mp5r82g4 25 17 multiple multiple JJ cord-354029-mp5r82g4 25 18 viral viral JJ cord-354029-mp5r82g4 25 19 glycoproteins glycoprotein NNS cord-354029-mp5r82g4 25 20 . . . cord-354029-mp5r82g4 26 1 There there EX cord-354029-mp5r82g4 26 2 are be VBP cord-354029-mp5r82g4 26 3 many many JJ cord-354029-mp5r82g4 26 4 excellent excellent JJ cord-354029-mp5r82g4 26 5 recent recent JJ cord-354029-mp5r82g4 26 6 reviews review NNS cord-354029-mp5r82g4 26 7 on on IN cord-354029-mp5r82g4 26 8 viral viral JJ cord-354029-mp5r82g4 26 9 fusion fusion NN cord-354029-mp5r82g4 26 10 and and CC cord-354029-mp5r82g4 26 11 the the DT cord-354029-mp5r82g4 26 12 glycoproteins glycoprotein NNS cord-354029-mp5r82g4 26 13 that that WDT cord-354029-mp5r82g4 26 14 mediate mediate VBP cord-354029-mp5r82g4 26 15 this this DT cord-354029-mp5r82g4 26 16 process process NN cord-354029-mp5r82g4 26 17 ( ( -LRB- cord-354029-mp5r82g4 26 18 Durell Durell NNP cord-354029-mp5r82g4 26 19 et et FW cord-354029-mp5r82g4 26 20 al al NNP cord-354029-mp5r82g4 26 21 . . . cord-354029-mp5r82g4 26 22 1997 1997 CD cord-354029-mp5r82g4 26 23 ; ; : cord-354029-mp5r82g4 26 24 Eckert Eckert NNP cord-354029-mp5r82g4 26 25 and and CC cord-354029-mp5r82g4 26 26 Kim Kim NNP cord-354029-mp5r82g4 26 27 2001 2001 CD cord-354029-mp5r82g4 26 28 ; ; : cord-354029-mp5r82g4 26 29 Heinz Heinz NNP cord-354029-mp5r82g4 26 30 and and CC cord-354029-mp5r82g4 26 31 Allison Allison NNP cord-354029-mp5r82g4 26 32 2001 2001 CD cord-354029-mp5r82g4 26 33 ; ; : cord-354029-mp5r82g4 26 34 Skehel Skehel NNP cord-354029-mp5r82g4 26 35 and and CC cord-354029-mp5r82g4 26 36 Wiley Wiley NNP cord-354029-mp5r82g4 26 37 2000 2000 CD cord-354029-mp5r82g4 26 38 ; ; : cord-354029-mp5r82g4 26 39 Weissenhorn Weissenhorn NNP cord-354029-mp5r82g4 26 40 et et NNP cord-354029-mp5r82g4 26 41 al al NNP cord-354029-mp5r82g4 26 42 . . . cord-354029-mp5r82g4 26 43 1999 1999 CD cord-354029-mp5r82g4 26 44 ) ) -RRB- cord-354029-mp5r82g4 26 45 . . . cord-354029-mp5r82g4 27 1 The the DT cord-354029-mp5r82g4 27 2 goal goal NN cord-354029-mp5r82g4 27 3 of of IN cord-354029-mp5r82g4 27 4 this this DT cord-354029-mp5r82g4 27 5 review review NN cord-354029-mp5r82g4 27 6 is be VBZ cord-354029-mp5r82g4 27 7 to to TO cord-354029-mp5r82g4 27 8 give give VB cord-354029-mp5r82g4 27 9 the the DT cord-354029-mp5r82g4 27 10 reader reader NN cord-354029-mp5r82g4 27 11 an an DT cord-354029-mp5r82g4 27 12 appreciation appreciation NN cord-354029-mp5r82g4 27 13 for for IN cord-354029-mp5r82g4 27 14 the the DT cord-354029-mp5r82g4 27 15 diversity diversity NN cord-354029-mp5r82g4 27 16 of of IN cord-354029-mp5r82g4 27 17 viral viral JJ cord-354029-mp5r82g4 27 18 fusion fusion NN cord-354029-mp5r82g4 27 19 mechanisms mechanism NNS cord-354029-mp5r82g4 27 20 . . . cord-354029-mp5r82g4 28 1 2 2 LS cord-354029-mp5r82g4 29 1 All all DT cord-354029-mp5r82g4 29 2 fusion fusion NN cord-354029-mp5r82g4 29 3 proteins protein NNS cord-354029-mp5r82g4 29 4 exist exist VBP cord-354029-mp5r82g4 29 5 on on IN cord-354029-mp5r82g4 29 6 virion virion NN cord-354029-mp5r82g4 29 7 surfaces surface NNS cord-354029-mp5r82g4 29 8 in in IN cord-354029-mp5r82g4 29 9 a a DT cord-354029-mp5r82g4 29 10 metastable metastable JJ cord-354029-mp5r82g4 29 11 state state NN cord-354029-mp5r82g4 29 12 in in IN cord-354029-mp5r82g4 29 13 which which WDT cord-354029-mp5r82g4 29 14 the the DT cord-354029-mp5r82g4 29 15 fusion fusion NN cord-354029-mp5r82g4 29 16 peptide peptide NN cord-354029-mp5r82g4 29 17 , , , cord-354029-mp5r82g4 29 18 a a DT cord-354029-mp5r82g4 29 19 critical critical JJ cord-354029-mp5r82g4 29 20 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 29 21 sequence sequence NN cord-354029-mp5r82g4 29 22 , , , cord-354029-mp5r82g4 29 23 is be VBZ cord-354029-mp5r82g4 29 24 hidden hide VBN cord-354029-mp5r82g4 29 25 or or CC cord-354029-mp5r82g4 29 26 shielded shield VBN cord-354029-mp5r82g4 29 27 within within IN cord-354029-mp5r82g4 29 28 the the DT cord-354029-mp5r82g4 29 29 glycoprotein glycoprotein NN cord-354029-mp5r82g4 29 30 oligomer oligomer NNP cord-354029-mp5r82g4 30 1 ( ( -LRB- cord-354029-mp5r82g4 30 2 Carr Carr NNP cord-354029-mp5r82g4 30 3 et et FW cord-354029-mp5r82g4 30 4 al al NNP cord-354029-mp5r82g4 30 5 . . . cord-354029-mp5r82g4 31 1 1997 1997 CD cord-354029-mp5r82g4 31 2 ; ; : cord-354029-mp5r82g4 31 3 Hernandez Hernandez NNP cord-354029-mp5r82g4 31 4 et et NNP cord-354029-mp5r82g4 31 5 al al NNP cord-354029-mp5r82g4 31 6 . . . cord-354029-mp5r82g4 32 1 1996 1996 CD cord-354029-mp5r82g4 32 2 ; ; : cord-354029-mp5r82g4 32 3 Rey Rey NNP cord-354029-mp5r82g4 32 4 et et NNP cord-354029-mp5r82g4 32 5 al al NNP cord-354029-mp5r82g4 32 6 . . NNP cord-354029-mp5r82g4 32 7 1995 1995 CD cord-354029-mp5r82g4 32 8 ; ; : cord-354029-mp5r82g4 32 9 Skehel Skehel NNP cord-354029-mp5r82g4 32 10 and and CC cord-354029-mp5r82g4 32 11 Wiley Wiley NNP cord-354029-mp5r82g4 32 12 2000 2000 CD cord-354029-mp5r82g4 32 13 ; ; : cord-354029-mp5r82g4 32 14 Wilson Wilson NNP cord-354029-mp5r82g4 32 15 et et NNP cord-354029-mp5r82g4 32 16 al al NNP cord-354029-mp5r82g4 32 17 . . NNP cord-354029-mp5r82g4 32 18 1981 1981 CD cord-354029-mp5r82g4 32 19 ) ) -RRB- cord-354029-mp5r82g4 32 20 . . . cord-354029-mp5r82g4 33 1 After after IN cord-354029-mp5r82g4 33 2 activation activation NN cord-354029-mp5r82g4 33 3 , , , cord-354029-mp5r82g4 33 4 the the DT cord-354029-mp5r82g4 33 5 fusion fusion NN cord-354029-mp5r82g4 33 6 peptides peptide NNS cord-354029-mp5r82g4 33 7 are be VBP cord-354029-mp5r82g4 33 8 rendered render VBN cord-354029-mp5r82g4 33 9 accessible accessible JJ cord-354029-mp5r82g4 33 10 for for IN cord-354029-mp5r82g4 33 11 interaction interaction NN cord-354029-mp5r82g4 33 12 with with IN cord-354029-mp5r82g4 33 13 a a DT cord-354029-mp5r82g4 33 14 target target NN cord-354029-mp5r82g4 33 15 membrane membrane NN cord-354029-mp5r82g4 33 16 . . . cord-354029-mp5r82g4 34 1 A a DT cord-354029-mp5r82g4 34 2 major major JJ cord-354029-mp5r82g4 34 3 distinction distinction NN cord-354029-mp5r82g4 34 4 among among IN cord-354029-mp5r82g4 34 5 viral viral JJ cord-354029-mp5r82g4 34 6 fusion fusion NN cord-354029-mp5r82g4 34 7 proteins protein NNS cord-354029-mp5r82g4 34 8 is be VBZ cord-354029-mp5r82g4 34 9 the the DT cord-354029-mp5r82g4 34 10 " " `` cord-354029-mp5r82g4 34 11 trigger trigger NN cord-354029-mp5r82g4 34 12 " " '' cord-354029-mp5r82g4 34 13 for for IN cord-354029-mp5r82g4 34 14 activation activation NN cord-354029-mp5r82g4 34 15 . . . cord-354029-mp5r82g4 35 1 There there EX cord-354029-mp5r82g4 35 2 are be VBP cord-354029-mp5r82g4 35 3 two two CD cord-354029-mp5r82g4 35 4 well well RB cord-354029-mp5r82g4 35 5 - - HYPH cord-354029-mp5r82g4 35 6 recognized recognize VBN cord-354029-mp5r82g4 35 7 mechanisms mechanism NNS cord-354029-mp5r82g4 35 8 : : : cord-354029-mp5r82g4 35 9 ( ( -LRB- cord-354029-mp5r82g4 35 10 1 1 LS cord-354029-mp5r82g4 35 11 ) ) -RRB- cord-354029-mp5r82g4 35 12 exposure exposure NN cord-354029-mp5r82g4 35 13 to to IN cord-354029-mp5r82g4 35 14 low low JJ cord-354029-mp5r82g4 35 15 pH ph NN cord-354029-mp5r82g4 35 16 and and CC cord-354029-mp5r82g4 35 17 ( ( -LRB- cord-354029-mp5r82g4 35 18 2 2 LS cord-354029-mp5r82g4 35 19 ) ) -RRB- cord-354029-mp5r82g4 35 20 specific specific JJ cord-354029-mp5r82g4 35 21 interactions interaction NNS cord-354029-mp5r82g4 35 22 with with IN cord-354029-mp5r82g4 35 23 target target NN cord-354029-mp5r82g4 35 24 cell cell NN cord-354029-mp5r82g4 35 25 receptors receptor NNS cord-354029-mp5r82g4 35 26 at at IN cord-354029-mp5r82g4 35 27 neutral neutral JJ cord-354029-mp5r82g4 36 1 pH. pH. NNP cord-354029-mp5r82g4 36 2 A a DT cord-354029-mp5r82g4 36 3 third third JJ cord-354029-mp5r82g4 36 4 mechanism mechanism NN cord-354029-mp5r82g4 36 5 involving involve VBG cord-354029-mp5r82g4 36 6 receptor receptor NN cord-354029-mp5r82g4 36 7 priming prime VBG cord-354029-mp5r82g4 36 8 at at IN cord-354029-mp5r82g4 36 9 neutral neutral JJ cord-354029-mp5r82g4 36 10 pH pH NNP cord-354029-mp5r82g4 36 11 followed follow VBN cord-354029-mp5r82g4 36 12 by by IN cord-354029-mp5r82g4 36 13 further further JJ cord-354029-mp5r82g4 36 14 activation activation NN cord-354029-mp5r82g4 36 15 at at IN cord-354029-mp5r82g4 36 16 low low JJ cord-354029-mp5r82g4 36 17 pH pH NNP cord-354029-mp5r82g4 36 18 was be VBD cord-354029-mp5r82g4 36 19 recently recently RB cord-354029-mp5r82g4 36 20 proposed propose VBN cord-354029-mp5r82g4 37 1 ( ( -LRB- cord-354029-mp5r82g4 37 2 Mothes Mothes NNP cord-354029-mp5r82g4 37 3 et et NNP cord-354029-mp5r82g4 37 4 al al NNP cord-354029-mp5r82g4 37 5 . . . cord-354029-mp5r82g4 37 6 2000 2000 CD cord-354029-mp5r82g4 37 7 ) ) -RRB- cord-354029-mp5r82g4 37 8 . . . cord-354029-mp5r82g4 38 1 Orthomyxoviruses Orthomyxoviruses NNP cord-354029-mp5r82g4 38 2 , , , cord-354029-mp5r82g4 38 3 togaviruses togaviruse NNS cord-354029-mp5r82g4 38 4 , , , cord-354029-mp5r82g4 38 5 flaviviruses flavivirus NNS cord-354029-mp5r82g4 38 6 , , , cord-354029-mp5r82g4 38 7 rhabdoviruses rhabdovirus NNS cord-354029-mp5r82g4 38 8 , , , cord-354029-mp5r82g4 38 9 bunyaviruses bunyaviruses NNP cord-354029-mp5r82g4 38 10 , , , cord-354029-mp5r82g4 38 11 arenaviruses arenaviruses NNP cord-354029-mp5r82g4 38 12 , , , cord-354029-mp5r82g4 38 13 and and CC cord-354029-mp5r82g4 38 14 , , , cord-354029-mp5r82g4 38 15 apparently apparently RB cord-354029-mp5r82g4 38 16 , , , cord-354029-mp5r82g4 38 17 filoviruses filovirus NNS cord-354029-mp5r82g4 38 18 require require VBP cord-354029-mp5r82g4 38 19 low low JJ cord-354029-mp5r82g4 38 20 pH ph NN cord-354029-mp5r82g4 38 21 to to TO cord-354029-mp5r82g4 38 22 fuse fuse VB cord-354029-mp5r82g4 38 23 with with IN cord-354029-mp5r82g4 38 24 target target NN cord-354029-mp5r82g4 38 25 membranes membrane NNS cord-354029-mp5r82g4 38 26 ( ( -LRB- cord-354029-mp5r82g4 38 27 Table table NN cord-354029-mp5r82g4 38 28 1 1 CD cord-354029-mp5r82g4 38 29 ) ) -RRB- cord-354029-mp5r82g4 39 1 ( ( -LRB- cord-354029-mp5r82g4 39 2 Doms Doms NNP cord-354029-mp5r82g4 39 3 et et FW cord-354029-mp5r82g4 39 4 al al NNP cord-354029-mp5r82g4 39 5 . . . cord-354029-mp5r82g4 40 1 1985 1985 CD cord-354029-mp5r82g4 40 2 ; ; : cord-354029-mp5r82g4 40 3 Gaudin Gaudin NNP cord-354029-mp5r82g4 40 4 et et NNP cord-354029-mp5r82g4 40 5 al al NNP cord-354029-mp5r82g4 40 6 . . . cord-354029-mp5r82g4 41 1 1999b 1999b CD cord-354029-mp5r82g4 42 1 ; ; : cord-354029-mp5r82g4 42 2 Stegmann Stegmann NNP cord-354029-mp5r82g4 42 3 et et NNP cord-354029-mp5r82g4 42 4 al al NNP cord-354029-mp5r82g4 42 5 . . NNP cord-354029-mp5r82g4 42 6 1987 1987 CD cord-354029-mp5r82g4 42 7 ; ; : cord-354029-mp5r82g4 42 8 . . . cord-354029-mp5r82g4 43 1 These these DT cord-354029-mp5r82g4 43 2 viruses virus NNS cord-354029-mp5r82g4 43 3 are be VBP cord-354029-mp5r82g4 43 4 endocytosed endocytose VBN cord-354029-mp5r82g4 43 5 after after IN cord-354029-mp5r82g4 43 6 binding bind VBG cord-354029-mp5r82g4 43 7 to to IN cord-354029-mp5r82g4 43 8 the the DT cord-354029-mp5r82g4 43 9 target target NN cord-354029-mp5r82g4 43 10 cell cell NN cord-354029-mp5r82g4 43 11 surface surface NN cord-354029-mp5r82g4 43 12 . . . cord-354029-mp5r82g4 44 1 The the DT cord-354029-mp5r82g4 44 2 low low JJ cord-354029-mp5r82g4 44 3 - - HYPH cord-354029-mp5r82g4 44 4 pH ph NN cord-354029-mp5r82g4 44 5 environment environment NN cord-354029-mp5r82g4 44 6 of of IN cord-354029-mp5r82g4 44 7 the the DT cord-354029-mp5r82g4 44 8 endosome endosome NN cord-354029-mp5r82g4 44 9 activates activate VBZ cord-354029-mp5r82g4 44 10 the the DT cord-354029-mp5r82g4 44 11 viral viral JJ cord-354029-mp5r82g4 44 12 fusion fusion NN cord-354029-mp5r82g4 44 13 protein protein NN cord-354029-mp5r82g4 44 14 to to TO cord-354029-mp5r82g4 44 15 convert convert VB cord-354029-mp5r82g4 44 16 from from IN cord-354029-mp5r82g4 44 17 a a DT cord-354029-mp5r82g4 44 18 metastable metastable JJ cord-354029-mp5r82g4 44 19 state state NN cord-354029-mp5r82g4 44 20 to to IN cord-354029-mp5r82g4 44 21 one one CD cord-354029-mp5r82g4 44 22 that that WDT cord-354029-mp5r82g4 44 23 is be VBZ cord-354029-mp5r82g4 44 24 capable capable JJ cord-354029-mp5r82g4 44 25 of of IN cord-354029-mp5r82g4 44 26 driving drive VBG cord-354029-mp5r82g4 44 27 fusion fusion NN cord-354029-mp5r82g4 44 28 . . . cord-354029-mp5r82g4 45 1 Although although IN cord-354029-mp5r82g4 45 2 the the DT cord-354029-mp5r82g4 45 3 presence presence NN cord-354029-mp5r82g4 45 4 of of IN cord-354029-mp5r82g4 45 5 a a DT cord-354029-mp5r82g4 45 6 receptor receptor NN cord-354029-mp5r82g4 45 7 may may MD cord-354029-mp5r82g4 45 8 modulate modulate VB cord-354029-mp5r82g4 45 9 the the DT cord-354029-mp5r82g4 45 10 rate rate NN cord-354029-mp5r82g4 45 11 or or CC cord-354029-mp5r82g4 45 12 extent extent NN cord-354029-mp5r82g4 45 13 of of IN cord-354029-mp5r82g4 45 14 fusion fusion NN cord-354029-mp5r82g4 45 15 Stegmann Stegmann NNP cord-354029-mp5r82g4 45 16 et et NNP cord-354029-mp5r82g4 45 17 al al NNP cord-354029-mp5r82g4 45 18 . . . cord-354029-mp5r82g4 46 1 1996 1996 CD cord-354029-mp5r82g4 46 2 ; ; : cord-354029-mp5r82g4 46 3 White White NNP cord-354029-mp5r82g4 46 4 et et NNP cord-354029-mp5r82g4 46 5 al al NNP cord-354029-mp5r82g4 46 6 . . . cord-354029-mp5r82g4 46 7 1982 1982 CD cord-354029-mp5r82g4 46 8 ) ) -RRB- cord-354029-mp5r82g4 46 9 , , , cord-354029-mp5r82g4 46 10 receptors receptor NNS cord-354029-mp5r82g4 46 11 are be VBP cord-354029-mp5r82g4 46 12 not not RB cord-354029-mp5r82g4 46 13 essential essential JJ cord-354029-mp5r82g4 46 14 for for IN cord-354029-mp5r82g4 46 15 low low JJ cord-354029-mp5r82g4 46 16 - - HYPH cord-354029-mp5r82g4 46 17 pH ph NN cord-354029-mp5r82g4 46 18 - - HYPH cord-354029-mp5r82g4 46 19 dependent dependent JJ cord-354029-mp5r82g4 46 20 fusion fusion NN cord-354029-mp5r82g4 46 21 . . . cord-354029-mp5r82g4 47 1 Low low JJ cord-354029-mp5r82g4 47 2 - - HYPH cord-354029-mp5r82g4 47 3 pH ph NN cord-354029-mp5r82g4 47 4 - - HYPH cord-354029-mp5r82g4 47 5 dependent dependent JJ cord-354029-mp5r82g4 47 6 fusion fusion NN cord-354029-mp5r82g4 47 7 generally generally RB cord-354029-mp5r82g4 47 8 occurs occur VBZ cord-354029-mp5r82g4 47 9 within within IN cord-354029-mp5r82g4 47 10 seconds second NNS cord-354029-mp5r82g4 47 11 to to IN cord-354029-mp5r82g4 47 12 minutes minute NNS cord-354029-mp5r82g4 47 13 at at IN cord-354029-mp5r82g4 47 14 37C 37c CD cord-354029-mp5r82g4 47 15 but but CC cord-354029-mp5r82g4 47 16 can can MD cord-354029-mp5r82g4 47 17 also also RB cord-354029-mp5r82g4 47 18 occur occur VB cord-354029-mp5r82g4 47 19 , , , cord-354029-mp5r82g4 47 20 albeit albeit IN cord-354029-mp5r82g4 47 21 more more RBR cord-354029-mp5r82g4 47 22 slowly slowly RB cord-354029-mp5r82g4 47 23 , , , cord-354029-mp5r82g4 47 24 at at IN cord-354029-mp5r82g4 47 25 T<22C. T<22C. NNP cord-354029-mp5r82g4 47 26 Four four CD cord-354029-mp5r82g4 47 27 main main JJ cord-354029-mp5r82g4 47 28 techniques technique NNS cord-354029-mp5r82g4 47 29 have have VBP cord-354029-mp5r82g4 47 30 been be VBN cord-354029-mp5r82g4 47 31 used use VBN cord-354029-mp5r82g4 47 32 to to TO cord-354029-mp5r82g4 47 33 assess assess VB cord-354029-mp5r82g4 47 34 whether whether IN cord-354029-mp5r82g4 47 35 a a DT cord-354029-mp5r82g4 47 36 virus virus NN cord-354029-mp5r82g4 47 37 requires require VBZ cord-354029-mp5r82g4 47 38 low low JJ cord-354029-mp5r82g4 47 39 pH ph NN cord-354029-mp5r82g4 47 40 to to TO cord-354029-mp5r82g4 47 41 fuse fuse VB cord-354029-mp5r82g4 47 42 . . . cord-354029-mp5r82g4 48 1 The the DT cord-354029-mp5r82g4 48 2 first first JJ cord-354029-mp5r82g4 48 3 technique technique NN cord-354029-mp5r82g4 48 4 is be VBZ cord-354029-mp5r82g4 48 5 testing test VBG cord-354029-mp5r82g4 48 6 the the DT cord-354029-mp5r82g4 48 7 effects effect NNS cord-354029-mp5r82g4 48 8 of of IN cord-354029-mp5r82g4 48 9 agents agent NNS cord-354029-mp5r82g4 48 10 , , , cord-354029-mp5r82g4 48 11 such such JJ cord-354029-mp5r82g4 48 12 as as IN cord-354029-mp5r82g4 48 13 bafilomycin bafilomycin NNS cord-354029-mp5r82g4 48 14 , , , cord-354029-mp5r82g4 48 15 that that WDT cord-354029-mp5r82g4 48 16 inhibit inhibit VBP cord-354029-mp5r82g4 48 17 endosomal endosomal JJ cord-354029-mp5r82g4 48 18 acidification acidification NN cord-354029-mp5r82g4 48 19 . . . cord-354029-mp5r82g4 49 1 In in IN cord-354029-mp5r82g4 49 2 some some DT cord-354029-mp5r82g4 49 3 studies study NNS cord-354029-mp5r82g4 49 4 of of IN cord-354029-mp5r82g4 49 5 this this DT cord-354029-mp5r82g4 49 6 type type NN cord-354029-mp5r82g4 49 7 , , , cord-354029-mp5r82g4 49 8 fusion fusion NN cord-354029-mp5r82g4 49 9 has have VBZ cord-354029-mp5r82g4 49 10 been be VBN cord-354029-mp5r82g4 49 11 measured measure VBN cord-354029-mp5r82g4 49 12 directly directly RB cord-354029-mp5r82g4 49 13 by by IN cord-354029-mp5r82g4 49 14 assessing assess VBG cord-354029-mp5r82g4 49 15 the the DT cord-354029-mp5r82g4 49 16 transfer transfer NN cord-354029-mp5r82g4 49 17 of of IN cord-354029-mp5r82g4 49 18 fluorescent fluorescent JJ cord-354029-mp5r82g4 49 19 probes probe NNS cord-354029-mp5r82g4 49 20 from from IN cord-354029-mp5r82g4 49 21 the the DT cord-354029-mp5r82g4 49 22 virus virus NN cord-354029-mp5r82g4 49 23 to to IN cord-354029-mp5r82g4 49 24 the the DT cord-354029-mp5r82g4 49 25 target target NN cord-354029-mp5r82g4 49 26 cell cell NN cord-354029-mp5r82g4 49 27 ( ( -LRB- cord-354029-mp5r82g4 49 28 Earp Earp NNP cord-354029-mp5r82g4 49 29 et et NNP cord-354029-mp5r82g4 49 30 al al NNP cord-354029-mp5r82g4 49 31 . . NNP cord-354029-mp5r82g4 49 32 2003 2003 CD cord-354029-mp5r82g4 49 33 ; ; : cord-354029-mp5r82g4 49 34 Irurzun Irurzun NNP cord-354029-mp5r82g4 49 35 et et NNP cord-354029-mp5r82g4 49 36 al al NNP cord-354029-mp5r82g4 49 37 . . . cord-354029-mp5r82g4 49 38 1997 1997 CD cord-354029-mp5r82g4 49 39 ; ; : cord-354029-mp5r82g4 49 40 Zarkik Zarkik NNP cord-354029-mp5r82g4 49 41 et et NNP cord-354029-mp5r82g4 49 42 al al NNP cord-354029-mp5r82g4 49 43 . . . cord-354029-mp5r82g4 49 44 1997 1997 CD cord-354029-mp5r82g4 49 45 ) ) -RRB- cord-354029-mp5r82g4 49 46 . . . cord-354029-mp5r82g4 50 1 In in IN cord-354029-mp5r82g4 50 2 others other NNS cord-354029-mp5r82g4 50 3 , , , cord-354029-mp5r82g4 50 4 fusion fusion NN cord-354029-mp5r82g4 50 5 has have VBZ cord-354029-mp5r82g4 50 6 been be VBN cord-354029-mp5r82g4 50 7 inferred infer VBN cord-354029-mp5r82g4 50 8 by by IN cord-354029-mp5r82g4 50 9 monitoring monitor VBG cord-354029-mp5r82g4 50 10 postfusion postfusion NN cord-354029-mp5r82g4 50 11 events event NNS cord-354029-mp5r82g4 50 12 , , , cord-354029-mp5r82g4 50 13 such such JJ cord-354029-mp5r82g4 50 14 as as IN cord-354029-mp5r82g4 50 15 the the DT cord-354029-mp5r82g4 50 16 synthesis synthesis NN cord-354029-mp5r82g4 50 17 of of IN cord-354029-mp5r82g4 50 18 viral viral JJ cord-354029-mp5r82g4 50 19 DNA dna NN cord-354029-mp5r82g4 50 20 ( ( -LRB- cord-354029-mp5r82g4 50 21 Mothes Mothes NNP cord-354029-mp5r82g4 50 22 et et NNP cord-354029-mp5r82g4 50 23 al al NNP cord-354029-mp5r82g4 50 24 . . . cord-354029-mp5r82g4 50 25 2000 2000 CD cord-354029-mp5r82g4 50 26 ) ) -RRB- cord-354029-mp5r82g4 50 27 . . . cord-354029-mp5r82g4 51 1 A a DT cord-354029-mp5r82g4 51 2 second second JJ cord-354029-mp5r82g4 51 3 test test NN cord-354029-mp5r82g4 51 4 is be VBZ cord-354029-mp5r82g4 51 5 to to TO cord-354029-mp5r82g4 51 6 assess assess VB cord-354029-mp5r82g4 51 7 whether whether IN cord-354029-mp5r82g4 51 8 fusion fusion NN cord-354029-mp5r82g4 51 9 of of IN cord-354029-mp5r82g4 51 10 bound bind VBN cord-354029-mp5r82g4 51 11 virions virion NNS cord-354029-mp5r82g4 51 12 can can MD cord-354029-mp5r82g4 51 13 be be VB cord-354029-mp5r82g4 51 14 induced induce VBN cord-354029-mp5r82g4 51 15 by by IN cord-354029-mp5r82g4 51 16 briefly briefly RB cord-354029-mp5r82g4 51 17 warming warm VBG cord-354029-mp5r82g4 51 18 virus virus NN cord-354029-mp5r82g4 51 19 - - HYPH cord-354029-mp5r82g4 51 20 cell cell NN cord-354029-mp5r82g4 51 21 complexes complex NNS cord-354029-mp5r82g4 51 22 in in IN cord-354029-mp5r82g4 51 23 low low JJ cord-354029-mp5r82g4 51 24 - - HYPH cord-354029-mp5r82g4 51 25 pH ph NN cord-354029-mp5r82g4 51 26 medium medium NN cord-354029-mp5r82g4 51 27 ( ( -LRB- cord-354029-mp5r82g4 51 28 Mothes Mothes NNP cord-354029-mp5r82g4 51 29 et et NNP cord-354029-mp5r82g4 51 30 al al NNP cord-354029-mp5r82g4 51 31 . . . cord-354029-mp5r82g4 51 32 2000 2000 CD cord-354029-mp5r82g4 51 33 ; ; : cord-354029-mp5r82g4 51 34 . . . cord-354029-mp5r82g4 52 1 A a DT cord-354029-mp5r82g4 52 2 third third JJ cord-354029-mp5r82g4 52 3 test test NN cord-354029-mp5r82g4 52 4 is be VBZ cord-354029-mp5r82g4 52 5 to to TO cord-354029-mp5r82g4 52 6 assess assess VB cord-354029-mp5r82g4 52 7 whether whether IN cord-354029-mp5r82g4 52 8 pretreatment pretreatment NN cord-354029-mp5r82g4 52 9 of of IN cord-354029-mp5r82g4 52 10 virions virion NNS cord-354029-mp5r82g4 52 11 at at IN cord-354029-mp5r82g4 52 12 low low JJ cord-354029-mp5r82g4 52 13 pH ph NN cord-354029-mp5r82g4 52 14 ( ( -LRB- cord-354029-mp5r82g4 52 15 in in IN cord-354029-mp5r82g4 52 16 the the DT cord-354029-mp5r82g4 52 17 absence absence NN cord-354029-mp5r82g4 52 18 of of IN cord-354029-mp5r82g4 52 19 target target NN cord-354029-mp5r82g4 52 20 membranes membrane NNS cord-354029-mp5r82g4 52 21 ) ) -RRB- cord-354029-mp5r82g4 52 22 inactivates inactivate VBZ cord-354029-mp5r82g4 52 23 the the DT cord-354029-mp5r82g4 52 24 virus virus NN cord-354029-mp5r82g4 52 25 for for IN cord-354029-mp5r82g4 52 26 fusion fusion NN cord-354029-mp5r82g4 52 27 . . . cord-354029-mp5r82g4 53 1 Some some DT cord-354029-mp5r82g4 53 2 ( ( -LRB- cord-354029-mp5r82g4 53 3 Bron Bron NNP cord-354029-mp5r82g4 53 4 et et FW cord-354029-mp5r82g4 53 5 al al NNP cord-354029-mp5r82g4 53 6 . . . cord-354029-mp5r82g4 53 7 1993 1993 CD cord-354029-mp5r82g4 54 1 ; ; : cord-354029-mp5r82g4 54 2 Corver Corver NNP cord-354029-mp5r82g4 54 3 et et NNP cord-354029-mp5r82g4 54 4 al al NNP cord-354029-mp5r82g4 54 5 . . . cord-354029-mp5r82g4 55 1 2000 2000 CD cord-354029-mp5r82g4 55 2 ; ; : cord-354029-mp5r82g4 55 3 Di Di NNP cord-354029-mp5r82g4 55 4 Simone Simone NNP cord-354029-mp5r82g4 55 5 and and CC cord-354029-mp5r82g4 55 6 Buchmeier Buchmeier NNP cord-354029-mp5r82g4 55 7 1995 1995 CD cord-354029-mp5r82g4 55 8 ; ; : cord-354029-mp5r82g4 55 9 Korte Korte NNP cord-354029-mp5r82g4 55 10 et et NNP cord-354029-mp5r82g4 55 11 al al NNP cord-354029-mp5r82g4 55 12 . . . cord-354029-mp5r82g4 56 1 1999 1999 CD cord-354029-mp5r82g4 56 2 ; ; : cord-354029-mp5r82g4 56 3 Nir Nir NNP cord-354029-mp5r82g4 56 4 et et NNP cord-354029-mp5r82g4 56 5 al al NNP cord-354029-mp5r82g4 56 6 . . . cord-354029-mp5r82g4 56 7 1990 1990 CD cord-354029-mp5r82g4 57 1 ; ; : cord-354029-mp5r82g4 57 2 Stegmann Stegmann NNP cord-354029-mp5r82g4 57 3 et et NNP cord-354029-mp5r82g4 57 4 al al NNP cord-354029-mp5r82g4 57 5 . . NNP cord-354029-mp5r82g4 57 6 1987 1987 CD cord-354029-mp5r82g4 57 7 ) ) -RRB- cord-354029-mp5r82g4 57 8 , , , cord-354029-mp5r82g4 57 9 but but CC cord-354029-mp5r82g4 57 10 not not RB cord-354029-mp5r82g4 57 11 all all DT cord-354029-mp5r82g4 58 1 ( ( -LRB- cord-354029-mp5r82g4 58 2 Puri Puri NNP cord-354029-mp5r82g4 58 3 et et FW cord-354029-mp5r82g4 58 4 al al NNP cord-354029-mp5r82g4 58 5 . . . cord-354029-mp5r82g4 58 6 1988 1988 CD cord-354029-mp5r82g4 58 7 ) ) -RRB- cord-354029-mp5r82g4 58 8 , , , cord-354029-mp5r82g4 58 9 viruses virus NNS cord-354029-mp5r82g4 58 10 that that WDT cord-354029-mp5r82g4 58 11 fuse fuse VBP cord-354029-mp5r82g4 58 12 at at IN cord-354029-mp5r82g4 58 13 low low JJ cord-354029-mp5r82g4 58 14 pH ph NN cord-354029-mp5r82g4 58 15 can can MD cord-354029-mp5r82g4 58 16 be be VB cord-354029-mp5r82g4 58 17 inactivated inactivate VBN cord-354029-mp5r82g4 58 18 by by IN cord-354029-mp5r82g4 58 19 this this DT cord-354029-mp5r82g4 58 20 method method NN cord-354029-mp5r82g4 58 21 . . . cord-354029-mp5r82g4 59 1 Viral viral JJ cord-354029-mp5r82g4 59 2 fusion fusion NN cord-354029-mp5r82g4 59 3 proteins protein NNS cord-354029-mp5r82g4 59 4 that that WDT cord-354029-mp5r82g4 59 5 are be VBP cord-354029-mp5r82g4 59 6 inactivated inactivate VBN cord-354029-mp5r82g4 59 7 by by IN cord-354029-mp5r82g4 59 8 low low JJ cord-354029-mp5r82g4 59 9 pH pH NNP cord-354029-mp5r82g4 59 10 undergo undergo VB cord-354029-mp5r82g4 59 11 irreversible irreversible JJ cord-354029-mp5r82g4 59 12 conformational conformational JJ cord-354029-mp5r82g4 59 13 changes change NNS cord-354029-mp5r82g4 59 14 . . . cord-354029-mp5r82g4 60 1 In in IN cord-354029-mp5r82g4 60 2 the the DT cord-354029-mp5r82g4 60 3 case case NN cord-354029-mp5r82g4 60 4 of of IN cord-354029-mp5r82g4 60 5 X:31 X:31 NNP cord-354029-mp5r82g4 60 6 HA HA NNP cord-354029-mp5r82g4 60 7 , , , cord-354029-mp5r82g4 60 8 this this DT cord-354029-mp5r82g4 60 9 results result VBZ cord-354029-mp5r82g4 60 10 in in IN cord-354029-mp5r82g4 60 11 insertion insertion NN cord-354029-mp5r82g4 60 12 of of IN cord-354029-mp5r82g4 60 13 the the DT cord-354029-mp5r82g4 60 14 fusion fusion NN cord-354029-mp5r82g4 60 15 peptide peptide NN cord-354029-mp5r82g4 60 16 into into IN cord-354029-mp5r82g4 60 17 the the DT cord-354029-mp5r82g4 60 18 viral viral JJ cord-354029-mp5r82g4 60 19 membrane membrane NN cord-354029-mp5r82g4 60 20 ( ( -LRB- cord-354029-mp5r82g4 60 21 Korte Korte NNP cord-354029-mp5r82g4 60 22 et et NNP cord-354029-mp5r82g4 60 23 al al NNP cord-354029-mp5r82g4 60 24 . . . cord-354029-mp5r82g4 60 25 1999 1999 CD cord-354029-mp5r82g4 60 26 ; ; : cord-354029-mp5r82g4 60 27 Weber Weber NNP cord-354029-mp5r82g4 60 28 et et NNP cord-354029-mp5r82g4 60 29 al al NNP cord-354029-mp5r82g4 60 30 . . . cord-354029-mp5r82g4 60 31 1994 1994 CD cord-354029-mp5r82g4 60 32 ) ) -RRB- cord-354029-mp5r82g4 60 33 . . . cord-354029-mp5r82g4 61 1 The the DT cord-354029-mp5r82g4 61 2 fourth fourth JJ cord-354029-mp5r82g4 61 3 test test NN cord-354029-mp5r82g4 61 4 is be VBZ cord-354029-mp5r82g4 61 5 to to TO cord-354029-mp5r82g4 61 6 assess assess VB cord-354029-mp5r82g4 61 7 whether whether IN cord-354029-mp5r82g4 61 8 cells cell NNS cord-354029-mp5r82g4 61 9 expressing express VBG cord-354029-mp5r82g4 61 10 the the DT cord-354029-mp5r82g4 61 11 viral viral JJ cord-354029-mp5r82g4 61 12 fusion fusion NN cord-354029-mp5r82g4 61 13 protein protein NN cord-354029-mp5r82g4 61 14 can can MD cord-354029-mp5r82g4 61 15 fuse fuse VB cord-354029-mp5r82g4 61 16 . . . cord-354029-mp5r82g4 62 1 Cell cell NN cord-354029-mp5r82g4 62 2 - - HYPH cord-354029-mp5r82g4 62 3 cell cell NN cord-354029-mp5r82g4 62 4 fusion fusion NN cord-354029-mp5r82g4 62 5 can can MD cord-354029-mp5r82g4 62 6 be be VB cord-354029-mp5r82g4 62 7 observed observe VBN cord-354029-mp5r82g4 62 8 by by IN cord-354029-mp5r82g4 62 9 light light NN cord-354029-mp5r82g4 62 10 or or CC cord-354029-mp5r82g4 62 11 fluorescence fluorescence NN cord-354029-mp5r82g4 62 12 microscopy microscopy NNS cord-354029-mp5r82g4 62 13 ( ( -LRB- cord-354029-mp5r82g4 62 14 Frey Frey NNP cord-354029-mp5r82g4 62 15 et et NNP cord-354029-mp5r82g4 62 16 al al NNP cord-354029-mp5r82g4 62 17 . . NNP cord-354029-mp5r82g4 62 18 1995 1995 CD cord-354029-mp5r82g4 62 19 ; ; : cord-354029-mp5r82g4 62 20 Melikyan Melikyan NNP cord-354029-mp5r82g4 62 21 et et NNP cord-354029-mp5r82g4 62 22 al al NNP cord-354029-mp5r82g4 62 23 . . . cord-354029-mp5r82g4 63 1 1997b 1997b CD cord-354029-mp5r82g4 63 2 ; ; : cord-354029-mp5r82g4 63 3 Mothes Mothes NNP cord-354029-mp5r82g4 63 4 et et NNP cord-354029-mp5r82g4 63 5 al al NNP cord-354029-mp5r82g4 63 6 . . . cord-354029-mp5r82g4 63 7 2000 2000 CD cord-354029-mp5r82g4 63 8 ) ) -RRB- cord-354029-mp5r82g4 63 9 , , , cord-354029-mp5r82g4 63 10 or or CC cord-354029-mp5r82g4 63 11 it -PRON- PRP cord-354029-mp5r82g4 63 12 can can MD cord-354029-mp5r82g4 63 13 be be VB cord-354029-mp5r82g4 63 14 scored score VBN cord-354029-mp5r82g4 63 15 with with IN cord-354029-mp5r82g4 63 16 gene gene NN cord-354029-mp5r82g4 63 17 reporter reporter NN cord-354029-mp5r82g4 63 18 assays assay NNS cord-354029-mp5r82g4 63 19 that that WDT cord-354029-mp5r82g4 63 20 monitor monitor VBP cord-354029-mp5r82g4 63 21 interactions interaction NNS cord-354029-mp5r82g4 63 22 of of IN cord-354029-mp5r82g4 63 23 components component NNS cord-354029-mp5r82g4 63 24 from from IN cord-354029-mp5r82g4 63 25 the the DT cord-354029-mp5r82g4 63 26 fusing fusing NN cord-354029-mp5r82g4 63 27 cells cell NNS cord-354029-mp5r82g4 63 28 Earp Earp NNP cord-354029-mp5r82g4 63 29 et et NNP cord-354029-mp5r82g4 63 30 al al NNP cord-354029-mp5r82g4 63 31 . . . cord-354029-mp5r82g4 64 1 2003 2003 CD cord-354029-mp5r82g4 64 2 ; ; : cord-354029-mp5r82g4 64 3 Feng Feng NNP cord-354029-mp5r82g4 64 4 et et FW cord-354029-mp5r82g4 64 5 al al NNP cord-354029-mp5r82g4 64 6 . . . cord-354029-mp5r82g4 65 1 1996 1996 CD cord-354029-mp5r82g4 65 2 ; ; : cord-354029-mp5r82g4 65 3 Nussbaum Nussbaum NNP cord-354029-mp5r82g4 65 4 et et NNP cord-354029-mp5r82g4 65 5 al al NNP cord-354029-mp5r82g4 65 6 . . . cord-354029-mp5r82g4 65 7 1994 1994 CD cord-354029-mp5r82g4 65 8 ) ) -RRB- cord-354029-mp5r82g4 65 9 . . . cord-354029-mp5r82g4 66 1 Although although IN cord-354029-mp5r82g4 66 2 cellcell cellcell NN cord-354029-mp5r82g4 66 3 fusion fusion NN cord-354029-mp5r82g4 66 4 assays assay NNS cord-354029-mp5r82g4 66 5 are be VBP cord-354029-mp5r82g4 66 6 relatively relatively RB cord-354029-mp5r82g4 66 7 simple simple JJ cord-354029-mp5r82g4 66 8 to to TO cord-354029-mp5r82g4 66 9 perform perform VB cord-354029-mp5r82g4 66 10 , , , cord-354029-mp5r82g4 66 11 the the DT cord-354029-mp5r82g4 66 12 results result NNS cord-354029-mp5r82g4 66 13 do do VBP cord-354029-mp5r82g4 66 14 not not RB cord-354029-mp5r82g4 66 15 always always RB cord-354029-mp5r82g4 66 16 correlate correlate VB cord-354029-mp5r82g4 66 17 with with IN cord-354029-mp5r82g4 66 18 virus virus NN cord-354029-mp5r82g4 66 19 - - HYPH cord-354029-mp5r82g4 66 20 cell cell NN cord-354029-mp5r82g4 66 21 fusion fusion NN cord-354029-mp5r82g4 66 22 or or CC cord-354029-mp5r82g4 66 23 infection infection NN cord-354029-mp5r82g4 66 24 ( ( -LRB- cord-354029-mp5r82g4 66 25 Earp Earp NNP cord-354029-mp5r82g4 66 26 et et NNP cord-354029-mp5r82g4 66 27 al al NNP cord-354029-mp5r82g4 66 28 . . . cord-354029-mp5r82g4 67 1 2003 2003 CD cord-354029-mp5r82g4 67 2 ; ; : cord-354029-mp5r82g4 67 3 Lavillette Lavillette NNP cord-354029-mp5r82g4 67 4 et et NNP cord-354029-mp5r82g4 67 5 al al NNP cord-354029-mp5r82g4 67 6 . . . cord-354029-mp5r82g4 68 1 1998 1998 CD cord-354029-mp5r82g4 68 2 ; ; : cord-354029-mp5r82g4 68 3 Schmid Schmid NNP cord-354029-mp5r82g4 68 4 et et NNP cord-354029-mp5r82g4 68 5 al al NNP cord-354029-mp5r82g4 68 6 . . . cord-354029-mp5r82g4 68 7 2000 2000 CD cord-354029-mp5r82g4 68 8 ) ) -RRB- cord-354029-mp5r82g4 68 9 . . . cord-354029-mp5r82g4 69 1 Many many JJ cord-354029-mp5r82g4 69 2 enveloped envelop VBN cord-354029-mp5r82g4 69 3 viruses virus NNS cord-354029-mp5r82g4 69 4 do do VBP cord-354029-mp5r82g4 69 5 not not RB cord-354029-mp5r82g4 69 6 require require VB cord-354029-mp5r82g4 69 7 low low JJ cord-354029-mp5r82g4 69 8 pH ph NN cord-354029-mp5r82g4 69 9 to to TO cord-354029-mp5r82g4 69 10 fuse fuse VB cord-354029-mp5r82g4 69 11 with with IN cord-354029-mp5r82g4 69 12 target target NN cord-354029-mp5r82g4 69 13 cells cell NNS cord-354029-mp5r82g4 69 14 . . . cord-354029-mp5r82g4 70 1 This this DT cord-354029-mp5r82g4 70 2 has have VBZ cord-354029-mp5r82g4 70 3 generally generally RB cord-354029-mp5r82g4 70 4 been be VBN cord-354029-mp5r82g4 70 5 established establish VBN cord-354029-mp5r82g4 70 6 in in IN cord-354029-mp5r82g4 70 7 controlled control VBN cord-354029-mp5r82g4 70 8 experiments experiment NNS cord-354029-mp5r82g4 70 9 using use VBG cord-354029-mp5r82g4 70 10 the the DT cord-354029-mp5r82g4 70 11 approaches approach NNS cord-354029-mp5r82g4 70 12 described describe VBN cord-354029-mp5r82g4 70 13 in in IN cord-354029-mp5r82g4 70 14 Sect Sect NNP cord-354029-mp5r82g4 70 15 . . . cord-354029-mp5r82g4 71 1 2.1 2.1 CD cord-354029-mp5r82g4 71 2 . . . cord-354029-mp5r82g4 72 1 Viruses virus NNS cord-354029-mp5r82g4 72 2 that that WDT cord-354029-mp5r82g4 72 3 can can MD cord-354029-mp5r82g4 72 4 fuse fuse VB cord-354029-mp5r82g4 72 5 at at IN cord-354029-mp5r82g4 72 6 neutral neutral JJ cord-354029-mp5r82g4 72 7 pH pH NNP cord-354029-mp5r82g4 72 8 include include VBP cord-354029-mp5r82g4 72 9 paramyxoviruses paramyxovirus NNS cord-354029-mp5r82g4 72 10 , , , cord-354029-mp5r82g4 72 11 herpesviruses herpesviruses NNP cord-354029-mp5r82g4 72 12 , , , cord-354029-mp5r82g4 72 13 coronaviruses coronaviruse NNS cord-354029-mp5r82g4 72 14 , , , cord-354029-mp5r82g4 72 15 poxviruses poxvirus NNS cord-354029-mp5r82g4 72 16 , , , cord-354029-mp5r82g4 72 17 and and CC cord-354029-mp5r82g4 72 18 most most JJS cord-354029-mp5r82g4 72 19 retroviruses retrovirus NNS cord-354029-mp5r82g4 72 20 ( ( -LRB- cord-354029-mp5r82g4 72 21 Table table NN cord-354029-mp5r82g4 72 22 1 1 CD cord-354029-mp5r82g4 72 23 ) ) -RRB- cord-354029-mp5r82g4 73 1 ( ( -LRB- cord-354029-mp5r82g4 73 2 Hernandez Hernandez NNP cord-354029-mp5r82g4 73 3 et et NNP cord-354029-mp5r82g4 73 4 al al NNP cord-354029-mp5r82g4 73 5 . . . cord-354029-mp5r82g4 74 1 1997 1997 CD cord-354029-mp5r82g4 74 2 ; ; : cord-354029-mp5r82g4 74 3 McClure McClure NNP cord-354029-mp5r82g4 74 4 et et NNP cord-354029-mp5r82g4 74 5 al al NNP cord-354029-mp5r82g4 74 6 . . NNP cord-354029-mp5r82g4 74 7 1990 1990 CD cord-354029-mp5r82g4 74 8 ; ; : cord-354029-mp5r82g4 74 9 Stein Stein NNP cord-354029-mp5r82g4 74 10 et et NNP cord-354029-mp5r82g4 74 11 al al NNP cord-354029-mp5r82g4 74 12 . . NNP cord-354029-mp5r82g4 74 13 1987 1987 CD cord-354029-mp5r82g4 74 14 ; ; . cord-354029-mp5r82g4 75 1 Taguchi Taguchi NNP cord-354029-mp5r82g4 75 2 and and CC cord-354029-mp5r82g4 75 3 Matsuyama Matsuyama NNP cord-354029-mp5r82g4 75 4 2002 2002 CD cord-354029-mp5r82g4 75 5 ) ) -RRB- cord-354029-mp5r82g4 75 6 . . . cord-354029-mp5r82g4 76 1 The the DT cord-354029-mp5r82g4 76 2 fusion fusion NN cord-354029-mp5r82g4 76 3 proteins protein NNS cord-354029-mp5r82g4 76 4 of of IN cord-354029-mp5r82g4 76 5 these these DT cord-354029-mp5r82g4 76 6 viruses virus NNS cord-354029-mp5r82g4 76 7 are be VBP cord-354029-mp5r82g4 76 8 activated activate VBN cord-354029-mp5r82g4 76 9 via via IN cord-354029-mp5r82g4 76 10 specific specific JJ cord-354029-mp5r82g4 76 11 interactions interaction NNS cord-354029-mp5r82g4 76 12 with with IN cord-354029-mp5r82g4 76 13 one one CD cord-354029-mp5r82g4 76 14 or or CC cord-354029-mp5r82g4 76 15 more more JJR cord-354029-mp5r82g4 76 16 receptors receptor NNS cord-354029-mp5r82g4 76 17 in in IN cord-354029-mp5r82g4 76 18 the the DT cord-354029-mp5r82g4 76 19 target target NN cord-354029-mp5r82g4 76 20 cell cell NN cord-354029-mp5r82g4 76 21 membrane membrane NN cord-354029-mp5r82g4 76 22 ( ( -LRB- cord-354029-mp5r82g4 76 23 Hernandez Hernandez NNP cord-354029-mp5r82g4 76 24 et et NNP cord-354029-mp5r82g4 76 25 al al NNP cord-354029-mp5r82g4 76 26 . . . cord-354029-mp5r82g4 77 1 1996 1996 CD cord-354029-mp5r82g4 77 2 ; ; : cord-354029-mp5r82g4 77 3 Hunter Hunter NNP cord-354029-mp5r82g4 77 4 1997 1997 CD cord-354029-mp5r82g4 77 5 ; ; : cord-354029-mp5r82g4 77 6 Stein Stein NNP cord-354029-mp5r82g4 77 7 et et NNP cord-354029-mp5r82g4 77 8 al al NNP cord-354029-mp5r82g4 77 9 . . NNP cord-354029-mp5r82g4 77 10 1987 1987 CD cord-354029-mp5r82g4 77 11 ) ) -RRB- cord-354029-mp5r82g4 77 12 . . . cord-354029-mp5r82g4 78 1 Viruses virus NNS cord-354029-mp5r82g4 78 2 that that WDT cord-354029-mp5r82g4 78 3 can can MD cord-354029-mp5r82g4 78 4 fuse fuse VB cord-354029-mp5r82g4 78 5 at at IN cord-354029-mp5r82g4 78 6 neutral neutral JJ cord-354029-mp5r82g4 78 7 pH pH NNP cord-354029-mp5r82g4 78 8 are be VBP cord-354029-mp5r82g4 78 9 thought think VBN cord-354029-mp5r82g4 78 10 to to TO cord-354029-mp5r82g4 78 11 do do VB cord-354029-mp5r82g4 78 12 so so RB cord-354029-mp5r82g4 78 13 at at IN cord-354029-mp5r82g4 78 14 the the DT cord-354029-mp5r82g4 78 15 plasma plasma NN cord-354029-mp5r82g4 78 16 membrane membrane NN cord-354029-mp5r82g4 78 17 . . . cord-354029-mp5r82g4 79 1 However however RB cord-354029-mp5r82g4 79 2 , , , cord-354029-mp5r82g4 79 3 they -PRON- PRP cord-354029-mp5r82g4 79 4 may may MD cord-354029-mp5r82g4 79 5 also also RB cord-354029-mp5r82g4 79 6 be be VB cord-354029-mp5r82g4 79 7 able able JJ cord-354029-mp5r82g4 79 8 to to TO cord-354029-mp5r82g4 79 9 fuse fuse VB cord-354029-mp5r82g4 79 10 with with IN cord-354029-mp5r82g4 79 11 neutral neutral JJ cord-354029-mp5r82g4 79 12 - - HYPH cord-354029-mp5r82g4 79 13 pH ph NN cord-354029-mp5r82g4 79 14 intracellular intracellular JJ cord-354029-mp5r82g4 79 15 compartments compartment NNS cord-354029-mp5r82g4 79 16 ( ( -LRB- cord-354029-mp5r82g4 79 17 e.g. e.g. RB cord-354029-mp5r82g4 79 18 , , , cord-354029-mp5r82g4 79 19 caveosomes caveosome NNS cord-354029-mp5r82g4 79 20 ) ) -RRB- cord-354029-mp5r82g4 79 21 that that WDT cord-354029-mp5r82g4 79 22 can can MD cord-354029-mp5r82g4 79 23 be be VB cord-354029-mp5r82g4 79 24 accessed access VBN cord-354029-mp5r82g4 79 25 through through IN cord-354029-mp5r82g4 79 26 newly newly RB cord-354029-mp5r82g4 79 27 recognized recognize VBN cord-354029-mp5r82g4 79 28 endocytic endocytic JJ cord-354029-mp5r82g4 79 29 pathways pathway NNS cord-354029-mp5r82g4 79 30 ( ( -LRB- cord-354029-mp5r82g4 79 31 Pelkmans Pelkmans NNPS cord-354029-mp5r82g4 79 32 and and CC cord-354029-mp5r82g4 79 33 Helenius Helenius NNP cord-354029-mp5r82g4 79 34 2003 2003 CD cord-354029-mp5r82g4 79 35 ; ; : cord-354029-mp5r82g4 79 36 Shin Shin NNP cord-354029-mp5r82g4 79 37 and and CC cord-354029-mp5r82g4 79 38 Abraham Abraham NNP cord-354029-mp5r82g4 79 39 2001 2001 CD cord-354029-mp5r82g4 79 40 ) ) -RRB- cord-354029-mp5r82g4 79 41 ( ( -LRB- cord-354029-mp5r82g4 79 42 see see VB cord-354029-mp5r82g4 79 43 also also RB cord-354029-mp5r82g4 79 44 the the DT cord-354029-mp5r82g4 79 45 chapter chapter NN cord-354029-mp5r82g4 79 46 by by IN cord-354029-mp5r82g4 79 47 Sieczkarski Sieczkarski NNP cord-354029-mp5r82g4 79 48 and and CC cord-354029-mp5r82g4 79 49 Whittaker Whittaker NNP cord-354029-mp5r82g4 79 50 , , , cord-354029-mp5r82g4 79 51 this this DT cord-354029-mp5r82g4 79 52 volume volume NN cord-354029-mp5r82g4 79 53 ) ) -RRB- cord-354029-mp5r82g4 79 54 . . . cord-354029-mp5r82g4 80 1 It -PRON- PRP cord-354029-mp5r82g4 80 2 is be VBZ cord-354029-mp5r82g4 80 3 important important JJ cord-354029-mp5r82g4 80 4 to to TO cord-354029-mp5r82g4 80 5 note note VB cord-354029-mp5r82g4 80 6 , , , cord-354029-mp5r82g4 80 7 however however RB cord-354029-mp5r82g4 80 8 , , , cord-354029-mp5r82g4 80 9 that that IN cord-354029-mp5r82g4 80 10 viruses virus NNS cord-354029-mp5r82g4 80 11 that that WDT cord-354029-mp5r82g4 80 12 can can MD cord-354029-mp5r82g4 80 13 fuse fuse VB cord-354029-mp5r82g4 80 14 at at IN cord-354029-mp5r82g4 80 15 neutral neutral JJ cord-354029-mp5r82g4 80 16 pH pH NNP cord-354029-mp5r82g4 80 17 may may MD cord-354029-mp5r82g4 80 18 also also RB cord-354029-mp5r82g4 80 19 possess possess VB cord-354029-mp5r82g4 80 20 the the DT cord-354029-mp5r82g4 80 21 ability ability NN cord-354029-mp5r82g4 80 22 to to TO cord-354029-mp5r82g4 80 23 fuse fuse VB cord-354029-mp5r82g4 80 24 at at IN cord-354029-mp5r82g4 80 25 low low JJ cord-354029-mp5r82g4 80 26 pH ph NN cord-354029-mp5r82g4 81 1 ( ( -LRB- cord-354029-mp5r82g4 81 2 Earp Earp NNP cord-354029-mp5r82g4 81 3 et et NNP cord-354029-mp5r82g4 81 4 al al NNP cord-354029-mp5r82g4 81 5 . . . cord-354029-mp5r82g4 82 1 2003 2003 CD cord-354029-mp5r82g4 82 2 ; ; : cord-354029-mp5r82g4 82 3 Fackler Fackler NNP cord-354029-mp5r82g4 82 4 and and CC cord-354029-mp5r82g4 82 5 Peterlin Peterlin NNP cord-354029-mp5r82g4 82 6 2000 2000 CD cord-354029-mp5r82g4 82 7 ) ) -RRB- cord-354029-mp5r82g4 82 8 . . . cord-354029-mp5r82g4 83 1 To to IN cord-354029-mp5r82g4 83 2 date date NN cord-354029-mp5r82g4 83 3 , , , cord-354029-mp5r82g4 83 4 neutral neutral JJ cord-354029-mp5r82g4 83 5 - - HYPH cord-354029-mp5r82g4 83 6 pH ph NN cord-354029-mp5r82g4 83 7 fusion fusion NN cord-354029-mp5r82g4 83 8 has have VBZ cord-354029-mp5r82g4 83 9 been be VBN cord-354029-mp5r82g4 83 10 found find VBN cord-354029-mp5r82g4 83 11 to to TO cord-354029-mp5r82g4 83 12 display display VB cord-354029-mp5r82g4 83 13 a a DT cord-354029-mp5r82g4 83 14 sharp sharp JJ cord-354029-mp5r82g4 83 15 temperature temperature NN cord-354029-mp5r82g4 83 16 threshold threshold NN cord-354029-mp5r82g4 83 17 , , , cord-354029-mp5r82g4 83 18 with with IN cord-354029-mp5r82g4 83 19 little little JJ cord-354029-mp5r82g4 83 20 or or CC cord-354029-mp5r82g4 83 21 no no DT cord-354029-mp5r82g4 83 22 fusion fusion NN cord-354029-mp5r82g4 83 23 occurring occur VBG cord-354029-mp5r82g4 83 24 at at IN cord-354029-mp5r82g4 83 25 T<20C. T<20C. NNP cord-354029-mp5r82g4 84 1 Recently recently RB cord-354029-mp5r82g4 84 2 , , , cord-354029-mp5r82g4 84 3 a a DT cord-354029-mp5r82g4 84 4 third third JJ cord-354029-mp5r82g4 84 5 model model NN cord-354029-mp5r82g4 84 6 was be VBD cord-354029-mp5r82g4 84 7 proposed propose VBN cord-354029-mp5r82g4 84 8 for for IN cord-354029-mp5r82g4 84 9 the the DT cord-354029-mp5r82g4 84 10 activation activation NN cord-354029-mp5r82g4 84 11 of of IN cord-354029-mp5r82g4 84 12 alpharetroviruses alpharetroviruse NNS cord-354029-mp5r82g4 84 13 . . . cord-354029-mp5r82g4 85 1 In in IN cord-354029-mp5r82g4 85 2 this this DT cord-354029-mp5r82g4 85 3 model model NN cord-354029-mp5r82g4 85 4 , , , cord-354029-mp5r82g4 85 5 activation activation NN cord-354029-mp5r82g4 85 6 of of IN cord-354029-mp5r82g4 85 7 the the DT cord-354029-mp5r82g4 85 8 alpharetroviral alpharetroviral JJ cord-354029-mp5r82g4 85 9 Env Env NNP cord-354029-mp5r82g4 85 10 begins begin VBZ cord-354029-mp5r82g4 85 11 with with IN cord-354029-mp5r82g4 85 12 receptor receptor NN cord-354029-mp5r82g4 85 13 binding bind VBG cord-354029-mp5r82g4 85 14 at at IN cord-354029-mp5r82g4 85 15 neutral neutral JJ cord-354029-mp5r82g4 85 16 pH pH NNP cord-354029-mp5r82g4 85 17 ( ( -LRB- cord-354029-mp5r82g4 85 18 at at IN cord-354029-mp5r82g4 85 19 T>22C T>22C NNP cord-354029-mp5r82g4 85 20 ) ) -RRB- cord-354029-mp5r82g4 85 21 but but CC cord-354029-mp5r82g4 85 22 is be VBZ cord-354029-mp5r82g4 85 23 only only RB cord-354029-mp5r82g4 85 24 complete complete JJ cord-354029-mp5r82g4 85 25 after after IN cord-354029-mp5r82g4 85 26 exposure exposure NN cord-354029-mp5r82g4 85 27 to to IN cord-354029-mp5r82g4 85 28 low low JJ cord-354029-mp5r82g4 85 29 pH ph NN cord-354029-mp5r82g4 85 30 ( ( -LRB- cord-354029-mp5r82g4 85 31 Mothes Mothes NNP cord-354029-mp5r82g4 85 32 et et FW cord-354029-mp5r82g4 85 33 al al NNP cord-354029-mp5r82g4 85 34 . . . cord-354029-mp5r82g4 85 35 2000 2000 CD cord-354029-mp5r82g4 85 36 ) ) -RRB- cord-354029-mp5r82g4 85 37 . . . cord-354029-mp5r82g4 86 1 The the DT cord-354029-mp5r82g4 86 2 role role NN cord-354029-mp5r82g4 86 3 of of IN cord-354029-mp5r82g4 86 4 low low JJ cord-354029-mp5r82g4 86 5 pH ph NN cord-354029-mp5r82g4 86 6 in in IN cord-354029-mp5r82g4 86 7 this this DT cord-354029-mp5r82g4 86 8 " " `` cord-354029-mp5r82g4 86 9 two two CD cord-354029-mp5r82g4 86 10 - - HYPH cord-354029-mp5r82g4 86 11 step step NN cord-354029-mp5r82g4 86 12 " " '' cord-354029-mp5r82g4 86 13 model model NN cord-354029-mp5r82g4 86 14 is be VBZ cord-354029-mp5r82g4 86 15 derived derive VBN cord-354029-mp5r82g4 86 16 from from IN cord-354029-mp5r82g4 86 17 two two CD cord-354029-mp5r82g4 86 18 key key JJ cord-354029-mp5r82g4 86 19 observations observation NNS cord-354029-mp5r82g4 86 20 : : : cord-354029-mp5r82g4 86 21 ( ( -LRB- cord-354029-mp5r82g4 86 22 1 1 LS cord-354029-mp5r82g4 86 23 ) ) -RRB- cord-354029-mp5r82g4 87 1 The the DT cord-354029-mp5r82g4 87 2 continuous continuous JJ cord-354029-mp5r82g4 87 3 presence presence NN cord-354029-mp5r82g4 87 4 of of IN cord-354029-mp5r82g4 87 5 endosomal endosomal NNP cord-354029-mp5r82g4 87 6 acidification acidification NN cord-354029-mp5r82g4 87 7 inhibitors inhibitor NNS cord-354029-mp5r82g4 87 8 prevents prevent VBZ cord-354029-mp5r82g4 87 9 production production NN cord-354029-mp5r82g4 87 10 of of IN cord-354029-mp5r82g4 87 11 alpharetroviral alpharetroviral JJ cord-354029-mp5r82g4 87 12 reverse reverse JJ cord-354029-mp5r82g4 87 13 transcripts transcript NNS cord-354029-mp5r82g4 87 14 , , , cord-354029-mp5r82g4 87 15 and and CC cord-354029-mp5r82g4 87 16 ( ( -LRB- cord-354029-mp5r82g4 87 17 2 2 LS cord-354029-mp5r82g4 87 18 ) ) -RRB- cord-354029-mp5r82g4 87 19 cells cell NNS cord-354029-mp5r82g4 87 20 expressing express VBG cord-354029-mp5r82g4 87 21 Env Env NNP cord-354029-mp5r82g4 87 22 and and CC cord-354029-mp5r82g4 87 23 cells cell NNS cord-354029-mp5r82g4 87 24 expressing express VBG cord-354029-mp5r82g4 87 25 the the DT cord-354029-mp5r82g4 87 26 viral viral JJ cord-354029-mp5r82g4 87 27 receptor receptor NN cord-354029-mp5r82g4 87 28 only only RB cord-354029-mp5r82g4 87 29 form form VB cord-354029-mp5r82g4 87 30 large large JJ cord-354029-mp5r82g4 87 31 syncytia syncytia NN cord-354029-mp5r82g4 87 32 after after IN cord-354029-mp5r82g4 87 33 exposure exposure NN cord-354029-mp5r82g4 87 34 to to IN cord-354029-mp5r82g4 87 35 low low JJ cord-354029-mp5r82g4 87 36 pH ph NN cord-354029-mp5r82g4 87 37 ( ( -LRB- cord-354029-mp5r82g4 87 38 Mothes Mothes NNP cord-354029-mp5r82g4 87 39 et et FW cord-354029-mp5r82g4 87 40 al al NNP cord-354029-mp5r82g4 87 41 . . . cord-354029-mp5r82g4 87 42 2000 2000 CD cord-354029-mp5r82g4 87 43 ) ) -RRB- cord-354029-mp5r82g4 87 44 . . . cord-354029-mp5r82g4 88 1 Our -PRON- PRP$ cord-354029-mp5r82g4 88 2 recent recent JJ cord-354029-mp5r82g4 88 3 work work NN cord-354029-mp5r82g4 88 4 indicates indicate VBZ cord-354029-mp5r82g4 88 5 that that IN cord-354029-mp5r82g4 88 6 alpharetrovirus alpharetrovirus NNP cord-354029-mp5r82g4 88 7 fusion fusion NN cord-354029-mp5r82g4 88 8 can can MD cord-354029-mp5r82g4 88 9 proceed proceed VB cord-354029-mp5r82g4 88 10 to to IN cord-354029-mp5r82g4 88 11 the the DT cord-354029-mp5r82g4 88 12 lipid lipid NN cord-354029-mp5r82g4 88 13 mixing mix VBG cord-354029-mp5r82g4 88 14 stage stage NN cord-354029-mp5r82g4 88 15 at at IN cord-354029-mp5r82g4 88 16 neutral neutral JJ cord-354029-mp5r82g4 88 17 pH pH NNP cord-354029-mp5r82g4 89 1 ( ( -LRB- cord-354029-mp5r82g4 89 2 Earp Earp NNP cord-354029-mp5r82g4 89 3 et et NNP cord-354029-mp5r82g4 89 4 al al NNP cord-354029-mp5r82g4 89 5 . . NNP cord-354029-mp5r82g4 89 6 2003 2003 CD cord-354029-mp5r82g4 89 7 ) ) -RRB- cord-354029-mp5r82g4 89 8 , , , cord-354029-mp5r82g4 89 9 and and CC cord-354029-mp5r82g4 89 10 that that IN cord-354029-mp5r82g4 89 11 receptor receptor NN cord-354029-mp5r82g4 89 12 binding binding NN cord-354029-mp5r82g4 89 13 and and CC cord-354029-mp5r82g4 89 14 low low JJ cord-354029-mp5r82g4 89 15 pH ph NN cord-354029-mp5r82g4 89 16 sequentially sequentially RB cord-354029-mp5r82g4 89 17 induce induce VB cord-354029-mp5r82g4 89 18 distinct distinct JJ cord-354029-mp5r82g4 89 19 conformational conformational JJ cord-354029-mp5r82g4 89 20 changes change NNS cord-354029-mp5r82g4 89 21 in in IN cord-354029-mp5r82g4 89 22 the the DT cord-354029-mp5r82g4 89 23 alpharetrovial alpharetrovial JJ cord-354029-mp5r82g4 89 24 Env Env NNP cord-354029-mp5r82g4 89 25 ( ( -LRB- cord-354029-mp5r82g4 89 26 Matsuyama Matsuyama NNP cord-354029-mp5r82g4 89 27 et et NNP cord-354029-mp5r82g4 89 28 al al NNP cord-354029-mp5r82g4 89 29 . . . cord-354029-mp5r82g4 89 30 2004 2004 CD cord-354029-mp5r82g4 89 31 ) ) -RRB- cord-354029-mp5r82g4 89 32 . . . cord-354029-mp5r82g4 90 1 Current current JJ cord-354029-mp5r82g4 90 2 work work NN cord-354029-mp5r82g4 90 3 is be VBZ cord-354029-mp5r82g4 90 4 now now RB cord-354029-mp5r82g4 90 5 focused focus VBN cord-354029-mp5r82g4 90 6 on on IN cord-354029-mp5r82g4 90 7 determining determine VBG cord-354029-mp5r82g4 90 8 the the DT cord-354029-mp5r82g4 90 9 precise precise JJ cord-354029-mp5r82g4 90 10 role role NN cord-354029-mp5r82g4 90 11 of of IN cord-354029-mp5r82g4 90 12 low low JJ cord-354029-mp5r82g4 90 13 pH ph NN cord-354029-mp5r82g4 90 14 in in IN cord-354029-mp5r82g4 90 15 the the DT cord-354029-mp5r82g4 90 16 fusion fusion NN cord-354029-mp5r82g4 90 17 cascade cascade NN cord-354029-mp5r82g4 90 18 . . . cord-354029-mp5r82g4 91 1 All all DT cord-354029-mp5r82g4 91 2 viral viral JJ cord-354029-mp5r82g4 91 3 fusion fusion NN cord-354029-mp5r82g4 91 4 proteins protein NNS cord-354029-mp5r82g4 91 5 contain contain VBP cord-354029-mp5r82g4 91 6 a a DT cord-354029-mp5r82g4 91 7 relatively relatively RB cord-354029-mp5r82g4 91 8 large large JJ cord-354029-mp5r82g4 91 9 ectodomain ectodomain NN cord-354029-mp5r82g4 91 10 , , , cord-354029-mp5r82g4 91 11 generally generally RB cord-354029-mp5r82g4 91 12 a a DT cord-354029-mp5r82g4 91 13 single single JJ cord-354029-mp5r82g4 91 14 transmembrane transmembrane NN cord-354029-mp5r82g4 91 15 domain domain NN cord-354029-mp5r82g4 91 16 , , , cord-354029-mp5r82g4 91 17 and and CC cord-354029-mp5r82g4 91 18 all all DT cord-354029-mp5r82g4 91 19 contain contain VBP cord-354029-mp5r82g4 91 20 a a DT cord-354029-mp5r82g4 91 21 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 91 22 tail tail NN cord-354029-mp5r82g4 91 23 . . . cord-354029-mp5r82g4 92 1 So so RB cord-354029-mp5r82g4 92 2 far far RB cord-354029-mp5r82g4 92 3 , , , cord-354029-mp5r82g4 92 4 two two CD cord-354029-mp5r82g4 92 5 major major JJ cord-354029-mp5r82g4 92 6 groups group NNS cord-354029-mp5r82g4 92 7 ( ( -LRB- cord-354029-mp5r82g4 92 8 class class NN cord-354029-mp5r82g4 92 9 I i NN cord-354029-mp5r82g4 92 10 and and CC cord-354029-mp5r82g4 92 11 class class NN cord-354029-mp5r82g4 92 12 II II NNP cord-354029-mp5r82g4 92 13 ) ) -RRB- cord-354029-mp5r82g4 92 14 have have VBP cord-354029-mp5r82g4 92 15 been be VBN cord-354029-mp5r82g4 92 16 defined define VBN cord-354029-mp5r82g4 92 17 based base VBN cord-354029-mp5r82g4 92 18 on on IN cord-354029-mp5r82g4 92 19 structural structural JJ cord-354029-mp5r82g4 92 20 criteria criterion NNS cord-354029-mp5r82g4 93 1 Lescar Lescar NNP cord-354029-mp5r82g4 93 2 et et FW cord-354029-mp5r82g4 93 3 al al NNP cord-354029-mp5r82g4 93 4 . . NNP cord-354029-mp5r82g4 93 5 2001 2001 CD cord-354029-mp5r82g4 93 6 ) ) -RRB- cord-354029-mp5r82g4 94 1 ( ( -LRB- cord-354029-mp5r82g4 94 2 Tables table NNS cord-354029-mp5r82g4 94 3 1 1 CD cord-354029-mp5r82g4 94 4 _SP cord-354029-mp5r82g4 94 5 and and CC cord-354029-mp5r82g4 94 6 2 2 CD cord-354029-mp5r82g4 94 7 ) ) -RRB- cord-354029-mp5r82g4 94 8 . . . cord-354029-mp5r82g4 95 1 Class class NN cord-354029-mp5r82g4 95 2 I -PRON- PRP cord-354029-mp5r82g4 95 3 fusion fusion NN cord-354029-mp5r82g4 95 4 proteins protein NNS cord-354029-mp5r82g4 95 5 are be VBP cord-354029-mp5r82g4 95 6 synthesized synthesize VBN cord-354029-mp5r82g4 95 7 as as IN cord-354029-mp5r82g4 95 8 precursors precursor NNS cord-354029-mp5r82g4 95 9 that that WDT cord-354029-mp5r82g4 95 10 are be VBP cord-354029-mp5r82g4 95 11 cleaved cleave VBN cord-354029-mp5r82g4 95 12 into into IN cord-354029-mp5r82g4 95 13 two two CD cord-354029-mp5r82g4 95 14 subunits subunit NNS cord-354029-mp5r82g4 95 15 by by IN cord-354029-mp5r82g4 95 16 host host NN cord-354029-mp5r82g4 95 17 cell cell NN cord-354029-mp5r82g4 95 18 proteases protease NNS cord-354029-mp5r82g4 95 19 . . . cord-354029-mp5r82g4 96 1 In in IN cord-354029-mp5r82g4 96 2 some some DT cord-354029-mp5r82g4 96 3 cases case NNS cord-354029-mp5r82g4 96 4 ( ( -LRB- cord-354029-mp5r82g4 96 5 e.g. e.g. RB cord-354029-mp5r82g4 96 6 , , , cord-354029-mp5r82g4 96 7 influenza influenza NN cord-354029-mp5r82g4 96 8 HA HA NNP cord-354029-mp5r82g4 96 9 ) ) -RRB- cord-354029-mp5r82g4 96 10 , , , cord-354029-mp5r82g4 96 11 the the DT cord-354029-mp5r82g4 96 12 two two CD cord-354029-mp5r82g4 96 13 subunits subunit NNS cord-354029-mp5r82g4 96 14 remain remain VBP cord-354029-mp5r82g4 96 15 associated associate VBN cord-354029-mp5r82g4 96 16 through through IN cord-354029-mp5r82g4 96 17 a a DT cord-354029-mp5r82g4 96 18 disulfide disulfide JJ cord-354029-mp5r82g4 96 19 bond bond NN cord-354029-mp5r82g4 96 20 ; ; : cord-354029-mp5r82g4 96 21 in in IN cord-354029-mp5r82g4 96 22 others other NNS cord-354029-mp5r82g4 96 23 ( ( -LRB- cord-354029-mp5r82g4 96 24 e.g. e.g. RB cord-354029-mp5r82g4 96 25 , , , cord-354029-mp5r82g4 96 26 HIV HIV NNP cord-354029-mp5r82g4 96 27 Env Env NNP cord-354029-mp5r82g4 96 28 ) ) -RRB- cord-354029-mp5r82g4 96 29 , , , cord-354029-mp5r82g4 96 30 the the DT cord-354029-mp5r82g4 96 31 two two CD cord-354029-mp5r82g4 96 32 subunits subunit NNS cord-354029-mp5r82g4 96 33 remain remain VBP cord-354029-mp5r82g4 96 34 associated associate VBN cord-354029-mp5r82g4 96 35 through through IN cord-354029-mp5r82g4 96 36 noncovalent noncovalent JJ cord-354029-mp5r82g4 96 37 interactions interaction NNS cord-354029-mp5r82g4 96 38 . . . cord-354029-mp5r82g4 97 1 The the DT cord-354029-mp5r82g4 97 2 proteolytic proteolytic JJ cord-354029-mp5r82g4 97 3 processing processing NN cord-354029-mp5r82g4 97 4 event event NN cord-354029-mp5r82g4 97 5 that that WDT cord-354029-mp5r82g4 97 6 generates generate VBZ cord-354029-mp5r82g4 97 7 the the DT cord-354029-mp5r82g4 97 8 two two CD cord-354029-mp5r82g4 97 9 subunits subunit NNS cord-354029-mp5r82g4 97 10 is be VBZ cord-354029-mp5r82g4 97 11 critical critical JJ cord-354029-mp5r82g4 97 12 , , , cord-354029-mp5r82g4 97 13 as as IN cord-354029-mp5r82g4 97 14 it -PRON- PRP cord-354029-mp5r82g4 97 15 creates create VBZ cord-354029-mp5r82g4 97 16 the the DT cord-354029-mp5r82g4 97 17 metastable metastable JJ cord-354029-mp5r82g4 97 18 state state NN cord-354029-mp5r82g4 97 19 of of IN cord-354029-mp5r82g4 97 20 the the DT cord-354029-mp5r82g4 97 21 fusion fusion NN cord-354029-mp5r82g4 97 22 protein protein NN cord-354029-mp5r82g4 98 1 ( ( -LRB- cord-354029-mp5r82g4 98 2 Chen Chen NNP cord-354029-mp5r82g4 98 3 et et NNP cord-354029-mp5r82g4 98 4 al al NNP cord-354029-mp5r82g4 98 5 . . NNP cord-354029-mp5r82g4 98 6 1998 1998 CD cord-354029-mp5r82g4 98 7 ) ) -RRB- cord-354029-mp5r82g4 98 8 . . . cord-354029-mp5r82g4 99 1 Class class NN cord-354029-mp5r82g4 99 2 I -PRON- PRP cord-354029-mp5r82g4 99 3 fusion fusion NN cord-354029-mp5r82g4 99 4 proteins protein NNS cord-354029-mp5r82g4 99 5 exist exist VBP cord-354029-mp5r82g4 99 6 as as RB cord-354029-mp5r82g4 99 7 relatively relatively RB cord-354029-mp5r82g4 99 8 long long JJ cord-354029-mp5r82g4 99 9 trimeric trimeric JJ cord-354029-mp5r82g4 99 10 spikes spike NNS cord-354029-mp5r82g4 99 11 in in IN cord-354029-mp5r82g4 99 12 both both DT cord-354029-mp5r82g4 99 13 their -PRON- PRP$ cord-354029-mp5r82g4 99 14 metastable metastable JJ cord-354029-mp5r82g4 99 15 and and CC cord-354029-mp5r82g4 99 16 activated activate VBN cord-354029-mp5r82g4 99 17 states state NNS cord-354029-mp5r82g4 99 18 . . . cord-354029-mp5r82g4 100 1 In in IN cord-354029-mp5r82g4 100 2 their -PRON- PRP$ cord-354029-mp5r82g4 100 3 metastable metastable JJ cord-354029-mp5r82g4 100 4 states state NNS cord-354029-mp5r82g4 100 5 , , , cord-354029-mp5r82g4 100 6 they -PRON- PRP cord-354029-mp5r82g4 100 7 project project VBP cord-354029-mp5r82g4 100 8 perpendicularly perpendicularly RB cord-354029-mp5r82g4 100 9 to to IN cord-354029-mp5r82g4 100 10 the the DT cord-354029-mp5r82g4 100 11 viral viral JJ cord-354029-mp5r82g4 100 12 membrane membrane NN cord-354029-mp5r82g4 100 13 . . . cord-354029-mp5r82g4 101 1 The the DT cord-354029-mp5r82g4 101 2 activated activate VBN cord-354029-mp5r82g4 101 3 forms form NNS cord-354029-mp5r82g4 101 4 of of IN cord-354029-mp5r82g4 101 5 the the DT cord-354029-mp5r82g4 101 6 fusion fusion NN cord-354029-mp5r82g4 101 7 subunits subunit NNS cord-354029-mp5r82g4 101 8 of of IN cord-354029-mp5r82g4 101 9 known know VBN cord-354029-mp5r82g4 101 10 class class NN cord-354029-mp5r82g4 101 11 I -PRON- PRP cord-354029-mp5r82g4 101 12 fusion fusion NN cord-354029-mp5r82g4 101 13 proteins protein NNS cord-354029-mp5r82g4 101 14 are be VBP cord-354029-mp5r82g4 101 15 highly highly RB cord-354029-mp5r82g4 101 16 a a DT cord-354029-mp5r82g4 101 17 - - HYPH cord-354029-mp5r82g4 101 18 helical helical JJ cord-354029-mp5r82g4 101 19 , , , cord-354029-mp5r82g4 101 20 and and CC cord-354029-mp5r82g4 101 21 the the DT cord-354029-mp5r82g4 101 22 final final JJ cord-354029-mp5r82g4 101 23 lowestenergy lowestenergy NNP cord-354029-mp5r82g4 101 24 ( ( -LRB- cord-354029-mp5r82g4 101 25 which which WDT cord-354029-mp5r82g4 101 26 we -PRON- PRP cord-354029-mp5r82g4 101 27 will will MD cord-354029-mp5r82g4 101 28 refer refer VB cord-354029-mp5r82g4 101 29 to to IN cord-354029-mp5r82g4 101 30 as as IN cord-354029-mp5r82g4 101 31 " " `` cord-354029-mp5r82g4 101 32 postfusion postfusion NN cord-354029-mp5r82g4 101 33 " " '' cord-354029-mp5r82g4 101 34 ) ) -RRB- cord-354029-mp5r82g4 101 35 forms form NNS cord-354029-mp5r82g4 101 36 ( ( -LRB- cord-354029-mp5r82g4 101 37 Fig Fig NNP cord-354029-mp5r82g4 101 38 . . . cord-354029-mp5r82g4 101 39 1 1 LS cord-354029-mp5r82g4 101 40 ) ) -RRB- cord-354029-mp5r82g4 101 41 contain contain VBP cord-354029-mp5r82g4 101 42 " " `` cord-354029-mp5r82g4 101 43 six six CD cord-354029-mp5r82g4 101 44 - - HYPH cord-354029-mp5r82g4 101 45 helix helix NN cord-354029-mp5r82g4 101 46 bundles bundle NNS cord-354029-mp5r82g4 101 47 " " '' cord-354029-mp5r82g4 101 48 ( ( -LRB- cord-354029-mp5r82g4 101 49 Bullough Bullough NNP cord-354029-mp5r82g4 101 50 et et NNP cord-354029-mp5r82g4 101 51 al al NNP cord-354029-mp5r82g4 101 52 . . . cord-354029-mp5r82g4 101 53 1994 1994 CD cord-354029-mp5r82g4 101 54 ; ; : cord-354029-mp5r82g4 101 55 Carr Carr NNP cord-354029-mp5r82g4 101 56 and and CC cord-354029-mp5r82g4 101 57 Kim Kim NNP cord-354029-mp5r82g4 101 58 1993 1993 CD cord-354029-mp5r82g4 101 59 ) ) -RRB- cord-354029-mp5r82g4 101 60 . . . cord-354029-mp5r82g4 102 1 All all DT cord-354029-mp5r82g4 102 2 six six CD cord-354029-mp5r82g4 102 3 - - HYPH cord-354029-mp5r82g4 102 4 helix helix NN cord-354029-mp5r82g4 102 5 bundles bundle NNS cord-354029-mp5r82g4 102 6 contain contain VBP cord-354029-mp5r82g4 102 7 a a DT cord-354029-mp5r82g4 102 8 relatively relatively RB cord-354029-mp5r82g4 102 9 long long JJ cord-354029-mp5r82g4 102 10 ( ( -LRB- cord-354029-mp5r82g4 102 11 65 65 CD cord-354029-mp5r82g4 102 12 - - SYM cord-354029-mp5r82g4 102 13 115 115 CD cord-354029-mp5r82g4 102 14 ) ) -RRB- cord-354029-mp5r82g4 102 15 central central JJ cord-354029-mp5r82g4 102 16 N n CD cord-354029-mp5r82g4 102 17 - - HYPH cord-354029-mp5r82g4 102 18 terminal terminal NN cord-354029-mp5r82g4 102 19 trimeric trimeric RB cord-354029-mp5r82g4 102 20 coiled coil VBN cord-354029-mp5r82g4 102 21 - - HYPH cord-354029-mp5r82g4 102 22 coil coil NN cord-354029-mp5r82g4 102 23 . . . cord-354029-mp5r82g4 103 1 Some some DT cord-354029-mp5r82g4 103 2 ( ( -LRB- cord-354029-mp5r82g4 103 3 e.g. e.g. RB cord-354029-mp5r82g4 103 4 , , , cord-354029-mp5r82g4 103 5 HIV HIV NNP cord-354029-mp5r82g4 103 6 Env Env NNP cord-354029-mp5r82g4 103 7 , , , cord-354029-mp5r82g4 103 8 SIV SIV NNP cord-354029-mp5r82g4 103 9 Env Env NNP cord-354029-mp5r82g4 103 10 , , , cord-354029-mp5r82g4 103 11 and and CC cord-354029-mp5r82g4 103 12 paramyxovirus paramyxovirus NNP cord-354029-mp5r82g4 103 13 F F NNP cord-354029-mp5r82g4 103 14 ) ) -RRB- cord-354029-mp5r82g4 103 15 form form VBP cord-354029-mp5r82g4 103 16 six six CD cord-354029-mp5r82g4 103 17 - - HYPH cord-354029-mp5r82g4 103 18 helix helix NN cord-354029-mp5r82g4 103 19 bundles bundle NNS cord-354029-mp5r82g4 103 20 that that WDT cord-354029-mp5r82g4 103 21 extend extend VBP cord-354029-mp5r82g4 103 22 to to IN cord-354029-mp5r82g4 103 23 their -PRON- PRP$ cord-354029-mp5r82g4 103 24 membrane membrane NN cord-354029-mp5r82g4 104 1 proximal proximal JJ cord-354029-mp5r82g4 104 2 ends end VBZ cord-354029-mp5r82g4 104 3 [ [ -LRB- cord-354029-mp5r82g4 104 4 i.e. i.e. FW cord-354029-mp5r82g4 104 5 , , , cord-354029-mp5r82g4 104 6 three three CD cord-354029-mp5r82g4 104 7 C c NN cord-354029-mp5r82g4 104 8 - - HYPH cord-354029-mp5r82g4 104 9 terminal terminal NN cord-354029-mp5r82g4 104 10 helices helix NNS cord-354029-mp5r82g4 104 11 ( ( -LRB- cord-354029-mp5r82g4 104 12 Fig Fig NNP cord-354029-mp5r82g4 104 13 . . . cord-354029-mp5r82g4 104 14 1A 1a NN cord-354029-mp5r82g4 104 15 , , . cord-354029-mp5r82g4 105 1 green green NNP cord-354029-mp5r82g4 105 2 ) ) -RRB- cord-354029-mp5r82g4 105 3 pack pack VB cord-354029-mp5r82g4 105 4 in in IN cord-354029-mp5r82g4 105 5 the the DT cord-354029-mp5r82g4 105 6 grooves groove NNS cord-354029-mp5r82g4 105 7 of of IN cord-354029-mp5r82g4 105 8 the the DT cord-354029-mp5r82g4 105 9 central central JJ cord-354029-mp5r82g4 105 10 coiled coil VBN cord-354029-mp5r82g4 105 11 - - HYPH cord-354029-mp5r82g4 105 12 coil coil NN cord-354029-mp5r82g4 105 13 ( ( -LRB- cord-354029-mp5r82g4 105 14 Fig Fig NNP cord-354029-mp5r82g4 105 15 . . . cord-354029-mp5r82g4 105 16 1A 1a NN cord-354029-mp5r82g4 105 17 , , , cord-354029-mp5r82g4 105 18 blue blue NNP cord-354029-mp5r82g4 105 19 ) ) -RRB- cord-354029-mp5r82g4 105 20 ] ] -RRB- cord-354029-mp5r82g4 105 21 . . . cord-354029-mp5r82g4 106 1 Others other NNS cord-354029-mp5r82g4 106 2 display display VBP cord-354029-mp5r82g4 106 3 a a DT cord-354029-mp5r82g4 106 4 mixture mixture NN cord-354029-mp5r82g4 106 5 of of IN cord-354029-mp5r82g4 106 6 helical helical JJ cord-354029-mp5r82g4 106 7 and and CC cord-354029-mp5r82g4 106 8 nonhelical nonhelical JJ cord-354029-mp5r82g4 106 9 segments segment NNS cord-354029-mp5r82g4 106 10 that that WDT cord-354029-mp5r82g4 106 11 pack pack VBP cord-354029-mp5r82g4 106 12 into into IN cord-354029-mp5r82g4 106 13 the the DT cord-354029-mp5r82g4 106 14 grooves groove NNS cord-354029-mp5r82g4 106 15 of of IN cord-354029-mp5r82g4 106 16 the the DT cord-354029-mp5r82g4 106 17 central central JJ cord-354029-mp5r82g4 106 18 coiledcoil coiledcoil NNP cord-354029-mp5r82g4 106 19 . . . cord-354029-mp5r82g4 107 1 For for IN cord-354029-mp5r82g4 107 2 example example NN cord-354029-mp5r82g4 107 3 , , , cord-354029-mp5r82g4 107 4 the the DT cord-354029-mp5r82g4 107 5 HA2 HA2 NNP cord-354029-mp5r82g4 107 6 subunit subunit NN cord-354029-mp5r82g4 107 7 of of IN cord-354029-mp5r82g4 107 8 influenza influenza NN cord-354029-mp5r82g4 107 9 HA HA NNP cord-354029-mp5r82g4 107 10 contains contain VBZ cord-354029-mp5r82g4 107 11 a a DT cord-354029-mp5r82g4 107 12 relatively relatively RB cord-354029-mp5r82g4 107 13 small small JJ cord-354029-mp5r82g4 107 14 six six CD cord-354029-mp5r82g4 107 15 - - HYPH cord-354029-mp5r82g4 107 16 helix helix NN cord-354029-mp5r82g4 107 17 bundle bundle NN cord-354029-mp5r82g4 107 18 ( ( -LRB- cord-354029-mp5r82g4 107 19 Fig Fig NNP cord-354029-mp5r82g4 107 20 . . NNP cord-354029-mp5r82g4 107 21 1 1 CD cord-354029-mp5r82g4 107 22 , , , cord-354029-mp5r82g4 107 23 green green JJ cord-354029-mp5r82g4 107 24 / / SYM cord-354029-mp5r82g4 107 25 blue blue NN cord-354029-mp5r82g4 107 26 ) ) -RRB- cord-354029-mp5r82g4 107 27 at at IN cord-354029-mp5r82g4 107 28 its -PRON- PRP$ cord-354029-mp5r82g4 107 29 membrane membrane NN cord-354029-mp5r82g4 107 30 distal distal JJ cord-354029-mp5r82g4 107 31 end end NN cord-354029-mp5r82g4 107 32 , , , cord-354029-mp5r82g4 107 33 followed follow VBN cord-354029-mp5r82g4 107 34 by by IN cord-354029-mp5r82g4 107 35 an an DT cord-354029-mp5r82g4 107 36 extended extended JJ cord-354029-mp5r82g4 107 37 chain chain NN cord-354029-mp5r82g4 107 38 ( ( -LRB- cord-354029-mp5r82g4 107 39 Fig Fig NNP cord-354029-mp5r82g4 107 40 . . NNP cord-354029-mp5r82g4 107 41 1 1 CD cord-354029-mp5r82g4 107 42 , , , cord-354029-mp5r82g4 107 43 yellow yellow JJ cord-354029-mp5r82g4 107 44 ) ) -RRB- cord-354029-mp5r82g4 107 45 that that WDT cord-354029-mp5r82g4 107 46 packs pack VBZ cord-354029-mp5r82g4 107 47 in in IN cord-354029-mp5r82g4 107 48 the the DT cord-354029-mp5r82g4 107 49 groove groove NN cord-354029-mp5r82g4 107 50 and and CC cord-354029-mp5r82g4 107 51 extends extend VBZ cord-354029-mp5r82g4 107 52 to to IN cord-354029-mp5r82g4 107 53 the the DT cord-354029-mp5r82g4 107 54 N n CD cord-354029-mp5r82g4 107 55 - - HYPH cord-354029-mp5r82g4 107 56 terminal terminal NN cord-354029-mp5r82g4 107 57 ( ( -LRB- cord-354029-mp5r82g4 107 58 membrane membrane NN cord-354029-mp5r82g4 107 59 proximal proximal NN cord-354029-mp5r82g4 107 60 ) ) -RRB- cord-354029-mp5r82g4 107 61 end end NN cord-354029-mp5r82g4 107 62 of of IN cord-354029-mp5r82g4 107 63 its -PRON- PRP$ cord-354029-mp5r82g4 107 64 central central JJ cord-354029-mp5r82g4 107 65 coiled coil VBN cord-354029-mp5r82g4 107 66 - - HYPH cord-354029-mp5r82g4 107 67 coil coil NN cord-354029-mp5r82g4 107 68 ( ( -LRB- cord-354029-mp5r82g4 107 69 Fig fig NN cord-354029-mp5r82g4 107 70 . . . cord-354029-mp5r82g4 107 71 1B 1b CD cord-354029-mp5r82g4 107 72 ) ) -RRB- cord-354029-mp5r82g4 107 73 . . . cord-354029-mp5r82g4 108 1 Because because IN cord-354029-mp5r82g4 108 2 of of IN cord-354029-mp5r82g4 108 3 these these DT cord-354029-mp5r82g4 108 4 variations variation NNS cord-354029-mp5r82g4 108 5 , , , cord-354029-mp5r82g4 108 6 the the DT cord-354029-mp5r82g4 108 7 postfusion postfusion NN cord-354029-mp5r82g4 108 8 forms form NNS cord-354029-mp5r82g4 108 9 of of IN cord-354029-mp5r82g4 108 10 class class NN cord-354029-mp5r82g4 108 11 I -PRON- PRP cord-354029-mp5r82g4 108 12 fusion fusion NN cord-354029-mp5r82g4 108 13 proteins protein NNS cord-354029-mp5r82g4 108 14 are be VBP cord-354029-mp5r82g4 108 15 often often RB cord-354029-mp5r82g4 108 16 referred refer VBN cord-354029-mp5r82g4 108 17 to to IN cord-354029-mp5r82g4 108 18 as as IN cord-354029-mp5r82g4 108 19 " " `` cord-354029-mp5r82g4 108 20 trimers trimer NNS cord-354029-mp5r82g4 108 21 of of IN cord-354029-mp5r82g4 108 22 hairpins hairpin NNS cord-354029-mp5r82g4 108 23 " " '' cord-354029-mp5r82g4 109 1 ( ( -LRB- cord-354029-mp5r82g4 109 2 Eckert Eckert NNP cord-354029-mp5r82g4 109 3 and and CC cord-354029-mp5r82g4 109 4 Kim Kim NNP cord-354029-mp5r82g4 109 5 2001 2001 CD cord-354029-mp5r82g4 109 6 ) ) -RRB- cord-354029-mp5r82g4 109 7 . . . cord-354029-mp5r82g4 110 1 The the DT cord-354029-mp5r82g4 110 2 general general JJ cord-354029-mp5r82g4 110 3 structure structure NN cord-354029-mp5r82g4 110 4 of of IN cord-354029-mp5r82g4 110 5 class class NN cord-354029-mp5r82g4 110 6 II II NNP cord-354029-mp5r82g4 110 7 fusion fusion NN cord-354029-mp5r82g4 110 8 proteins protein NNS cord-354029-mp5r82g4 110 9 is be VBZ cord-354029-mp5r82g4 110 10 quite quite RB cord-354029-mp5r82g4 110 11 different different JJ cord-354029-mp5r82g4 110 12 from from IN cord-354029-mp5r82g4 110 13 that that DT cord-354029-mp5r82g4 110 14 of of IN cord-354029-mp5r82g4 110 15 class class NN cord-354029-mp5r82g4 110 16 I -PRON- PRP cord-354029-mp5r82g4 110 17 fusion fusion NN cord-354029-mp5r82g4 110 18 proteins protein NNS cord-354029-mp5r82g4 110 19 . . . cord-354029-mp5r82g4 111 1 A a DT cord-354029-mp5r82g4 111 2 well well RB cord-354029-mp5r82g4 111 3 - - HYPH cord-354029-mp5r82g4 111 4 characterized characterize VBN cord-354029-mp5r82g4 111 5 example example NN cord-354029-mp5r82g4 111 6 is be VBZ cord-354029-mp5r82g4 111 7 the the DT cord-354029-mp5r82g4 111 8 envelope envelope NN cord-354029-mp5r82g4 111 9 glycoprotein glycoprotein NN cord-354029-mp5r82g4 111 10 ( ( -LRB- cord-354029-mp5r82g4 111 11 E e NN cord-354029-mp5r82g4 111 12 ) ) -RRB- cord-354029-mp5r82g4 111 13 of of IN cord-354029-mp5r82g4 111 14 tick tick NN cord-354029-mp5r82g4 111 15 - - HYPH cord-354029-mp5r82g4 111 16 borne bear VBN cord-354029-mp5r82g4 111 17 encephalitis encephalitis JJ cord-354029-mp5r82g4 111 18 ( ( -LRB- cord-354029-mp5r82g4 111 19 TBE TBE NNP cord-354029-mp5r82g4 111 20 ) ) -RRB- cord-354029-mp5r82g4 111 21 virus virus NN cord-354029-mp5r82g4 111 22 . . . cord-354029-mp5r82g4 112 1 During during IN cord-354029-mp5r82g4 112 2 biosynthesis biosynthesis NN cord-354029-mp5r82g4 112 3 , , , cord-354029-mp5r82g4 112 4 TBE TBE NNP cord-354029-mp5r82g4 112 5 E e NN cord-354029-mp5r82g4 112 6 and and CC cord-354029-mp5r82g4 112 7 a a DT cord-354029-mp5r82g4 112 8 second second JJ cord-354029-mp5r82g4 112 9 viral viral JJ cord-354029-mp5r82g4 112 10 membrane membrane NN cord-354029-mp5r82g4 112 11 glycoprotein glycoprotein NN cord-354029-mp5r82g4 112 12 , , , cord-354029-mp5r82g4 112 13 the the DT cord-354029-mp5r82g4 112 14 precursor precursor NN cord-354029-mp5r82g4 112 15 to to IN cord-354029-mp5r82g4 112 16 the the DT cord-354029-mp5r82g4 112 17 membrane membrane NN cord-354029-mp5r82g4 112 18 protein protein NN cord-354029-mp5r82g4 112 19 ( ( -LRB- cord-354029-mp5r82g4 112 20 prM prM NNP cord-354029-mp5r82g4 112 21 ) ) -RRB- cord-354029-mp5r82g4 112 22 , , , cord-354029-mp5r82g4 112 23 form form NN cord-354029-mp5r82g4 112 24 heterodimers heterodimer NNS cord-354029-mp5r82g4 112 25 . . . cord-354029-mp5r82g4 113 1 As as IN cord-354029-mp5r82g4 113 2 virions virion NNS cord-354029-mp5r82g4 113 3 ma- ma- . cord-354029-mp5r82g4 114 1 [ [ -LRB- cord-354029-mp5r82g4 114 2 Lamb Lamb NNP cord-354029-mp5r82g4 114 3 1993 1993 CD cord-354029-mp5r82g4 114 4 ; ; : cord-354029-mp5r82g4 115 1 Colman Colman NNP cord-354029-mp5r82g4 115 2 and and CC cord-354029-mp5r82g4 115 3 Lawrence Lawrence NNP cord-354029-mp5r82g4 115 4 2003 2003 CD cord-354029-mp5r82g4 115 5 ] ] -RRB- cord-354029-mp5r82g4 115 6 ture ture NNP cord-354029-mp5r82g4 115 7 , , , cord-354029-mp5r82g4 115 8 a a DT cord-354029-mp5r82g4 115 9 host host NN cord-354029-mp5r82g4 115 10 cell cell NN cord-354029-mp5r82g4 115 11 protease protease NN cord-354029-mp5r82g4 115 12 cleaves cleave VBZ cord-354029-mp5r82g4 115 13 prM prm JJ cord-354029-mp5r82g4 115 14 , , , cord-354029-mp5r82g4 115 15 resulting result VBG cord-354029-mp5r82g4 115 16 in in IN cord-354029-mp5r82g4 115 17 reorganization reorganization NN cord-354029-mp5r82g4 115 18 of of IN cord-354029-mp5r82g4 115 19 proteins protein NNS cord-354029-mp5r82g4 115 20 on on IN cord-354029-mp5r82g4 115 21 the the DT cord-354029-mp5r82g4 115 22 viral viral JJ cord-354029-mp5r82g4 115 23 surface surface NN cord-354029-mp5r82g4 115 24 ( ( -LRB- cord-354029-mp5r82g4 115 25 Allison Allison NNP cord-354029-mp5r82g4 115 26 et et NNP cord-354029-mp5r82g4 115 27 al al NNP cord-354029-mp5r82g4 115 28 . . NNP cord-354029-mp5r82g4 115 29 1995 1995 CD cord-354029-mp5r82g4 115 30 ) ) -RRB- cord-354029-mp5r82g4 115 31 . . . cord-354029-mp5r82g4 116 1 After after IN cord-354029-mp5r82g4 116 2 prM prm JJ cord-354029-mp5r82g4 116 3 cleavage cleavage NN cord-354029-mp5r82g4 116 4 , , , cord-354029-mp5r82g4 116 5 the the DT cord-354029-mp5r82g4 116 6 E e NN cord-354029-mp5r82g4 116 7 proteins protein NNS cord-354029-mp5r82g4 116 8 exist exist VBP cord-354029-mp5r82g4 116 9 as as IN cord-354029-mp5r82g4 116 10 metastable metastable JJ cord-354029-mp5r82g4 116 11 homodimers homodimer NNS cord-354029-mp5r82g4 116 12 . . . cord-354029-mp5r82g4 117 1 The the DT cord-354029-mp5r82g4 117 2 ectodomains ectodomain NNS cord-354029-mp5r82g4 117 3 of of IN cord-354029-mp5r82g4 117 4 the the DT cord-354029-mp5r82g4 117 5 dimer dimer NN cord-354029-mp5r82g4 117 6 are be VBP cord-354029-mp5r82g4 117 7 oriented orient VBN cord-354029-mp5r82g4 117 8 antiparallel antiparallel RB cord-354029-mp5r82g4 117 9 to to IN cord-354029-mp5r82g4 117 10 one one CD cord-354029-mp5r82g4 117 11 another another DT cord-354029-mp5r82g4 117 12 . . . cord-354029-mp5r82g4 118 1 In in IN cord-354029-mp5r82g4 118 2 further further JJ cord-354029-mp5r82g4 118 3 contrast contrast NN cord-354029-mp5r82g4 118 4 to to IN cord-354029-mp5r82g4 118 5 the the DT cord-354029-mp5r82g4 118 6 trimeric trimeric NNP cord-354029-mp5r82g4 118 7 class class NN cord-354029-mp5r82g4 119 1 I -PRON- PRP cord-354029-mp5r82g4 119 2 fusion fusion VBP cord-354029-mp5r82g4 119 3 protein protein NN cord-354029-mp5r82g4 119 4 spikes spike NNS cord-354029-mp5r82g4 119 5 , , , cord-354029-mp5r82g4 119 6 the the DT cord-354029-mp5r82g4 119 7 ectodomains ectodomain NNS cord-354029-mp5r82g4 119 8 of of IN cord-354029-mp5r82g4 119 9 the the DT cord-354029-mp5r82g4 119 10 E e NN cord-354029-mp5r82g4 119 11 homodimer homodimer NN cord-354029-mp5r82g4 119 12 lie lie NN cord-354029-mp5r82g4 119 13 parallel parallel JJ cord-354029-mp5r82g4 119 14 to to IN cord-354029-mp5r82g4 119 15 the the DT cord-354029-mp5r82g4 119 16 viral viral JJ cord-354029-mp5r82g4 119 17 membrane membrane NN cord-354029-mp5r82g4 119 18 and and CC cord-354029-mp5r82g4 119 19 close close RB cord-354029-mp5r82g4 119 20 to to IN cord-354029-mp5r82g4 119 21 the the DT cord-354029-mp5r82g4 119 22 surface surface NN cord-354029-mp5r82g4 119 23 . . . cord-354029-mp5r82g4 120 1 The the DT cord-354029-mp5r82g4 120 2 TBE TBE NNP cord-354029-mp5r82g4 120 3 E e NN cord-354029-mp5r82g4 120 4 protein protein NN cord-354029-mp5r82g4 120 5 is be VBZ cord-354029-mp5r82g4 120 6 composed compose VBN cord-354029-mp5r82g4 120 7 mostly mostly RB cord-354029-mp5r82g4 120 8 of of IN cord-354029-mp5r82g4 120 9 b b NN cord-354029-mp5r82g4 120 10 - - HYPH cord-354029-mp5r82g4 120 11 strand strand NN cord-354029-mp5r82g4 120 12 structure structure NN cord-354029-mp5r82g4 120 13 Rey Rey NNP cord-354029-mp5r82g4 120 14 et et NNP cord-354029-mp5r82g4 120 15 al al NNP cord-354029-mp5r82g4 120 16 . . NNP cord-354029-mp5r82g4 120 17 1995 1995 CD cord-354029-mp5r82g4 120 18 ) ) -RRB- cord-354029-mp5r82g4 120 19 . . . cord-354029-mp5r82g4 121 1 The the DT cord-354029-mp5r82g4 121 2 architecture architecture NN cord-354029-mp5r82g4 121 3 of of IN cord-354029-mp5r82g4 121 4 the the DT cord-354029-mp5r82g4 121 5 Semliki Semliki NNP cord-354029-mp5r82g4 121 6 Forest Forest NNP cord-354029-mp5r82g4 121 7 virus virus NN cord-354029-mp5r82g4 121 8 ( ( -LRB- cord-354029-mp5r82g4 121 9 SFV sfv NN cord-354029-mp5r82g4 121 10 ) ) -RRB- cord-354029-mp5r82g4 121 11 spike spike NN cord-354029-mp5r82g4 121 12 , , , cord-354029-mp5r82g4 121 13 another another DT cord-354029-mp5r82g4 121 14 well well RB cord-354029-mp5r82g4 121 15 - - HYPH cord-354029-mp5r82g4 121 16 characterized characterize VBN cord-354029-mp5r82g4 121 17 class class NN cord-354029-mp5r82g4 121 18 II II NNP cord-354029-mp5r82g4 121 19 fusion fusion NN cord-354029-mp5r82g4 121 20 protein protein NN cord-354029-mp5r82g4 121 21 , , , cord-354029-mp5r82g4 121 22 is be VBZ cord-354029-mp5r82g4 121 23 similar similar JJ cord-354029-mp5r82g4 121 24 to to IN cord-354029-mp5r82g4 121 25 that that DT cord-354029-mp5r82g4 121 26 of of IN cord-354029-mp5r82g4 121 27 TBE TBE NNP cord-354029-mp5r82g4 121 28 E e NN cord-354029-mp5r82g4 121 29 , , , cord-354029-mp5r82g4 121 30 but but CC cord-354029-mp5r82g4 121 31 in in IN cord-354029-mp5r82g4 121 32 this this DT cord-354029-mp5r82g4 121 33 case case NN cord-354029-mp5r82g4 121 34 , , , cord-354029-mp5r82g4 121 35 the the DT cord-354029-mp5r82g4 121 36 metastable metastable JJ cord-354029-mp5r82g4 121 37 oligomer oligomer NN cord-354029-mp5r82g4 121 38 is be VBZ cord-354029-mp5r82g4 121 39 a a DT cord-354029-mp5r82g4 121 40 heterodimer heterodimer NN cord-354029-mp5r82g4 121 41 of of IN cord-354029-mp5r82g4 121 42 two two CD cord-354029-mp5r82g4 121 43 membrane membrane NN cord-354029-mp5r82g4 121 44 - - HYPH cord-354029-mp5r82g4 121 45 anchored anchor VBN cord-354029-mp5r82g4 121 46 proteins protein NNS cord-354029-mp5r82g4 121 47 , , , cord-354029-mp5r82g4 121 48 E1 E1 NNP cord-354029-mp5r82g4 121 49 and and CC cord-354029-mp5r82g4 121 50 E2 E2 NNP cord-354029-mp5r82g4 121 51 , , , cord-354029-mp5r82g4 121 52 with with IN cord-354029-mp5r82g4 121 53 an an DT cord-354029-mp5r82g4 121 54 associated associated JJ cord-354029-mp5r82g4 121 55 small small JJ cord-354029-mp5r82g4 121 56 protein protein NN cord-354029-mp5r82g4 121 57 ( ( -LRB- cord-354029-mp5r82g4 121 58 E3 E3 NNP cord-354029-mp5r82g4 121 59 ) ) -RRB- cord-354029-mp5r82g4 121 60 . . . cord-354029-mp5r82g4 122 1 In in IN cord-354029-mp5r82g4 122 2 Sects sect NNS cord-354029-mp5r82g4 122 3 . . . cord-354029-mp5r82g4 123 1 4.1 4.1 CD cord-354029-mp5r82g4 123 2 - - SYM cord-354029-mp5r82g4 123 3 4.4 4.4 CD cord-354029-mp5r82g4 123 4 , , , cord-354029-mp5r82g4 123 5 we -PRON- PRP cord-354029-mp5r82g4 123 6 discuss discuss VBP cord-354029-mp5r82g4 123 7 a a DT cord-354029-mp5r82g4 123 8 few few JJ cord-354029-mp5r82g4 123 9 examples example NNS cord-354029-mp5r82g4 123 10 of of IN cord-354029-mp5r82g4 123 11 viral viral JJ cord-354029-mp5r82g4 123 12 fusion fusion NN cord-354029-mp5r82g4 123 13 proteins protein NNS cord-354029-mp5r82g4 123 14 that that WDT cord-354029-mp5r82g4 123 15 employ employ VBP cord-354029-mp5r82g4 123 16 different different JJ cord-354029-mp5r82g4 123 17 fusion fusion NN cord-354029-mp5r82g4 123 18 mechanisms mechanism NNS cord-354029-mp5r82g4 123 19 in in IN cord-354029-mp5r82g4 123 20 more more JJR cord-354029-mp5r82g4 123 21 detail detail NN cord-354029-mp5r82g4 123 22 . . . cord-354029-mp5r82g4 124 1 These these DT cord-354029-mp5r82g4 124 2 will will MD cord-354029-mp5r82g4 124 3 include include VB cord-354029-mp5r82g4 124 4 _SP cord-354029-mp5r82g4 124 5 High high JJ cord-354029-mp5r82g4 124 6 - - HYPH cord-354029-mp5r82g4 124 7 resolution resolution NN cord-354029-mp5r82g4 124 8 structures structure NNS cord-354029-mp5r82g4 124 9 are be VBP cord-354029-mp5r82g4 124 10 available available JJ cord-354029-mp5r82g4 124 11 for for IN cord-354029-mp5r82g4 124 12 both both CC cord-354029-mp5r82g4 124 13 the the DT cord-354029-mp5r82g4 124 14 complete complete JJ cord-354029-mp5r82g4 124 15 native native JJ cord-354029-mp5r82g4 124 16 ( ( -LRB- cord-354029-mp5r82g4 124 17 metastable metastable JJ cord-354029-mp5r82g4 124 18 ) ) -RRB- cord-354029-mp5r82g4 125 1 ( ( -LRB- cord-354029-mp5r82g4 125 2 Wilson Wilson NNP cord-354029-mp5r82g4 125 3 et et NNP cord-354029-mp5r82g4 125 4 al al NNP cord-354029-mp5r82g4 125 5 . . NNP cord-354029-mp5r82g4 125 6 1981 1981 CD cord-354029-mp5r82g4 125 7 ) ) -RRB- cord-354029-mp5r82g4 125 8 and and CC cord-354029-mp5r82g4 125 9 activated activate VBD cord-354029-mp5r82g4 126 1 ( ( -LRB- cord-354029-mp5r82g4 126 2 Bullough Bullough NNP cord-354029-mp5r82g4 126 3 et et NNP cord-354029-mp5r82g4 126 4 al al NNP cord-354029-mp5r82g4 126 5 . . . cord-354029-mp5r82g4 126 6 1994 1994 CD cord-354029-mp5r82g4 127 1 ; ; : cord-354029-mp5r82g4 127 2 Chen Chen NNP cord-354029-mp5r82g4 127 3 et et NNP cord-354029-mp5r82g4 127 4 al al NNP cord-354029-mp5r82g4 127 5 . . . cord-354029-mp5r82g4 127 6 1999 1999 CD cord-354029-mp5r82g4 127 7 ) ) -RRB- cord-354029-mp5r82g4 127 8 forms form NNS cord-354029-mp5r82g4 127 9 of of IN cord-354029-mp5r82g4 127 10 the the DT cord-354029-mp5r82g4 127 11 influenza influenza NN cord-354029-mp5r82g4 127 12 HA HA NNP cord-354029-mp5r82g4 127 13 . . . cord-354029-mp5r82g4 128 1 On on IN cord-354029-mp5r82g4 128 2 the the DT cord-354029-mp5r82g4 128 3 viral viral JJ cord-354029-mp5r82g4 128 4 surface surface NN cord-354029-mp5r82g4 128 5 , , , cord-354029-mp5r82g4 128 6 HA HA NNP cord-354029-mp5r82g4 128 7 exists exist VBZ cord-354029-mp5r82g4 128 8 as as IN cord-354029-mp5r82g4 128 9 a a DT cord-354029-mp5r82g4 128 10 trimer trimer NN cord-354029-mp5r82g4 128 11 of of IN cord-354029-mp5r82g4 128 12 heterodimers heterodimer NNS cord-354029-mp5r82g4 128 13 ( ( -LRB- cord-354029-mp5r82g4 128 14 Fig Fig NNP cord-354029-mp5r82g4 128 15 . . . cord-354029-mp5r82g4 128 16 2A 2a CD cord-354029-mp5r82g4 128 17 ) ) -RRB- cord-354029-mp5r82g4 128 18 . . . cord-354029-mp5r82g4 129 1 Each each DT cord-354029-mp5r82g4 129 2 heterodimer heterodimer NN cord-354029-mp5r82g4 129 3 consists consist VBZ cord-354029-mp5r82g4 129 4 of of IN cord-354029-mp5r82g4 129 5 HA1 HA1 NNP cord-354029-mp5r82g4 129 6 , , , cord-354029-mp5r82g4 129 7 which which WDT cord-354029-mp5r82g4 129 8 contains contain VBZ cord-354029-mp5r82g4 129 9 the the DT cord-354029-mp5r82g4 129 10 receptor receptor NN cord-354029-mp5r82g4 129 11 binding bind VBG cord-354029-mp5r82g4 129 12 domain domain NN cord-354029-mp5r82g4 129 13 ( ( -LRB- cord-354029-mp5r82g4 129 14 Fig Fig NNP cord-354029-mp5r82g4 129 15 . . NNP cord-354029-mp5r82g4 129 16 2 2 CD cord-354029-mp5r82g4 129 17 , , , cord-354029-mp5r82g4 129 18 gray gray JJ cord-354029-mp5r82g4 129 19 ) ) -RRB- cord-354029-mp5r82g4 129 20 , , , cord-354029-mp5r82g4 129 21 and and CC cord-354029-mp5r82g4 129 22 HA2 HA2 NNP cord-354029-mp5r82g4 129 23 , , , cord-354029-mp5r82g4 129 24 which which WDT cord-354029-mp5r82g4 129 25 contains contain VBZ cord-354029-mp5r82g4 129 26 the the DT cord-354029-mp5r82g4 129 27 fusion fusion NN cord-354029-mp5r82g4 129 28 peptide peptide NN cord-354029-mp5r82g4 129 29 ( ( -LRB- cord-354029-mp5r82g4 129 30 Fig Fig NNP cord-354029-mp5r82g4 129 31 . . NNP cord-354029-mp5r82g4 129 32 2 2 CD cord-354029-mp5r82g4 129 33 , , , cord-354029-mp5r82g4 129 34 red red JJ cord-354029-mp5r82g4 129 35 ) ) -RRB- cord-354029-mp5r82g4 129 36 and and CC cord-354029-mp5r82g4 129 37 the the DT cord-354029-mp5r82g4 129 38 transmembrane transmembrane NN cord-354029-mp5r82g4 129 39 domain domain NN cord-354029-mp5r82g4 129 40 ( ( -LRB- cord-354029-mp5r82g4 129 41 located locate VBN cord-354029-mp5r82g4 129 42 at at IN cord-354029-mp5r82g4 129 43 the the DT cord-354029-mp5r82g4 129 44 C C NNP cord-354029-mp5r82g4 129 45 - - HYPH cord-354029-mp5r82g4 129 46 terminus terminus NN cord-354029-mp5r82g4 129 47 ) ) -RRB- cord-354029-mp5r82g4 129 48 . . . cord-354029-mp5r82g4 130 1 In in IN cord-354029-mp5r82g4 130 2 the the DT cord-354029-mp5r82g4 130 3 native native JJ cord-354029-mp5r82g4 130 4 ( ( -LRB- cord-354029-mp5r82g4 130 5 neutral neutral JJ cord-354029-mp5r82g4 130 6 pH pH NNP cord-354029-mp5r82g4 130 7 ) ) -RRB- cord-354029-mp5r82g4 130 8 structure structure NN cord-354029-mp5r82g4 130 9 , , , cord-354029-mp5r82g4 130 10 the the DT cord-354029-mp5r82g4 130 11 fusion fusion NN cord-354029-mp5r82g4 130 12 peptide peptide NN cord-354029-mp5r82g4 130 13 is be VBZ cord-354029-mp5r82g4 130 14 buried bury VBN cord-354029-mp5r82g4 130 15 within within IN cord-354029-mp5r82g4 130 16 the the DT cord-354029-mp5r82g4 130 17 HA HA NNP cord-354029-mp5r82g4 130 18 oligomer oligomer NNP cord-354029-mp5r82g4 130 19 . . . cord-354029-mp5r82g4 131 1 Three three CD cord-354029-mp5r82g4 131 2 long long JJ cord-354029-mp5r82g4 131 3 helices helix NNS cord-354029-mp5r82g4 131 4 , , , cord-354029-mp5r82g4 131 5 one one CD cord-354029-mp5r82g4 131 6 from from IN cord-354029-mp5r82g4 131 7 each each DT cord-354029-mp5r82g4 131 8 monomer monomer NN cord-354029-mp5r82g4 131 9 , , , cord-354029-mp5r82g4 131 10 come come VB cord-354029-mp5r82g4 131 11 together together RB cord-354029-mp5r82g4 131 12 to to TO cord-354029-mp5r82g4 131 13 form form VB cord-354029-mp5r82g4 131 14 the the DT cord-354029-mp5r82g4 131 15 triple triple RB cord-354029-mp5r82g4 131 16 - - HYPH cord-354029-mp5r82g4 131 17 stranded stranded JJ cord-354029-mp5r82g4 131 18 coiled coiled JJ cord-354029-mp5r82g4 131 19 - - HYPH cord-354029-mp5r82g4 131 20 coil coil NN cord-354029-mp5r82g4 131 21 of of IN cord-354029-mp5r82g4 131 22 the the DT cord-354029-mp5r82g4 131 23 metastable metastable JJ cord-354029-mp5r82g4 131 24 trimer trimer NN cord-354029-mp5r82g4 131 25 ( ( -LRB- cord-354029-mp5r82g4 131 26 Fig Fig NNP cord-354029-mp5r82g4 131 27 . . . cord-354029-mp5r82g4 131 28 2A 2a NN cord-354029-mp5r82g4 131 29 and and CC cord-354029-mp5r82g4 131 30 B b NN cord-354029-mp5r82g4 131 31 , , , cord-354029-mp5r82g4 131 32 blue blue JJ cord-354029-mp5r82g4 131 33 and and CC cord-354029-mp5r82g4 131 34 green green JJ cord-354029-mp5r82g4 131 35 ) ) -RRB- cord-354029-mp5r82g4 131 36 . . . cord-354029-mp5r82g4 132 1 Low low JJ cord-354029-mp5r82g4 132 2 - - HYPH cord-354029-mp5r82g4 132 3 pH ph NN cord-354029-mp5r82g4 132 4 - - HYPH cord-354029-mp5r82g4 132 5 induced induce VBN cord-354029-mp5r82g4 132 6 conformational conformational JJ cord-354029-mp5r82g4 132 7 changes change NNS cord-354029-mp5r82g4 132 8 within within IN cord-354029-mp5r82g4 132 9 influenza influenza NN cord-354029-mp5r82g4 132 10 HA HA NNP cord-354029-mp5r82g4 132 11 . . . cord-354029-mp5r82g4 133 1 HA1 HA1 NNP cord-354029-mp5r82g4 133 2 is be VBZ cord-354029-mp5r82g4 133 3 depicted depict VBN cord-354029-mp5r82g4 133 4 in in IN cord-354029-mp5r82g4 133 5 gray gray JJ cord-354029-mp5r82g4 133 6 . . . cord-354029-mp5r82g4 134 1 The the DT cord-354029-mp5r82g4 134 2 fusion fusion NN cord-354029-mp5r82g4 134 3 peptide peptide NN cord-354029-mp5r82g4 134 4 is be VBZ cord-354029-mp5r82g4 134 5 red red JJ cord-354029-mp5r82g4 134 6 ( ( -LRB- cord-354029-mp5r82g4 134 7 HA2 HA2 NNP cord-354029-mp5r82g4 134 8 residues residue NNS cord-354029-mp5r82g4 134 9 1 1 CD cord-354029-mp5r82g4 134 10 - - HYPH cord-354029-mp5r82g4 134 11 24 24 CD cord-354029-mp5r82g4 134 12 ) ) -RRB- cord-354029-mp5r82g4 134 13 . . . cord-354029-mp5r82g4 135 1 The the DT cord-354029-mp5r82g4 135 2 coiled coiled JJ cord-354029-mp5r82g4 135 3 - - HYPH cord-354029-mp5r82g4 135 4 coil coil NN cord-354029-mp5r82g4 135 5 is be VBZ cord-354029-mp5r82g4 135 6 blue blue JJ cord-354029-mp5r82g4 135 7 , , , cord-354029-mp5r82g4 135 8 with with IN cord-354029-mp5r82g4 135 9 the the DT cord-354029-mp5r82g4 135 10 C C NNP cord-354029-mp5r82g4 135 11 - - HYPH cord-354029-mp5r82g4 135 12 terminal terminal NN cord-354029-mp5r82g4 135 13 helix helix NN cord-354029-mp5r82g4 135 14 colored color VBN cord-354029-mp5r82g4 135 15 green green NN cord-354029-mp5r82g4 135 16 . . . cord-354029-mp5r82g4 136 1 The the DT cord-354029-mp5r82g4 136 2 C C NNP cord-354029-mp5r82g4 136 3 - - HYPH cord-354029-mp5r82g4 136 4 terminal terminal NN cord-354029-mp5r82g4 136 5 extended extended JJ cord-354029-mp5r82g4 136 6 region region NN cord-354029-mp5r82g4 136 7 is be VBZ cord-354029-mp5r82g4 136 8 yellow yellow JJ cord-354029-mp5r82g4 136 9 . . . cord-354029-mp5r82g4 137 1 The the DT cord-354029-mp5r82g4 137 2 transmembrane transmembrane NN cord-354029-mp5r82g4 137 3 domain domain NN cord-354029-mp5r82g4 137 4 ( ( -LRB- cord-354029-mp5r82g4 137 5 not not RB cord-354029-mp5r82g4 137 6 shown show VBN cord-354029-mp5r82g4 137 7 ) ) -RRB- cord-354029-mp5r82g4 137 8 attaches attach VBZ cord-354029-mp5r82g4 137 9 to to IN cord-354029-mp5r82g4 137 10 the the DT cord-354029-mp5r82g4 137 11 C c NN cord-354029-mp5r82g4 137 12 - - HYPH cord-354029-mp5r82g4 137 13 terminal terminal NN cord-354029-mp5r82g4 137 14 end end NN cord-354029-mp5r82g4 137 15 , , , cord-354029-mp5r82g4 137 16 indicated indicate VBN cord-354029-mp5r82g4 137 17 by by IN cord-354029-mp5r82g4 137 18 " " `` cord-354029-mp5r82g4 137 19 C C NNP cord-354029-mp5r82g4 137 20 " " '' cord-354029-mp5r82g4 137 21 , , , cord-354029-mp5r82g4 137 22 of of IN cord-354029-mp5r82g4 137 23 HA2 HA2 NNP cord-354029-mp5r82g4 137 24 . . . cord-354029-mp5r82g4 138 1 A a DT cord-354029-mp5r82g4 138 2 model model NN cord-354029-mp5r82g4 138 3 for for IN cord-354029-mp5r82g4 138 4 conformational conformational JJ cord-354029-mp5r82g4 138 5 changes change NNS cord-354029-mp5r82g4 138 6 : : : cord-354029-mp5r82g4 139 1 A a DT cord-354029-mp5r82g4 140 1 In in IN cord-354029-mp5r82g4 140 2 the the DT cord-354029-mp5r82g4 140 3 native native JJ cord-354029-mp5r82g4 140 4 , , , cord-354029-mp5r82g4 140 5 metastable metastable JJ cord-354029-mp5r82g4 140 6 , , , cord-354029-mp5r82g4 140 7 structure structure NN cord-354029-mp5r82g4 140 8 of of IN cord-354029-mp5r82g4 140 9 HA HA NNP cord-354029-mp5r82g4 140 10 , , , cord-354029-mp5r82g4 140 11 the the DT cord-354029-mp5r82g4 140 12 fusion fusion NN cord-354029-mp5r82g4 140 13 peptides peptide NNS cord-354029-mp5r82g4 140 14 are be VBP cord-354029-mp5r82g4 140 15 buried bury VBN cord-354029-mp5r82g4 140 16 within within IN cord-354029-mp5r82g4 140 17 the the DT cord-354029-mp5r82g4 140 18 trimer trimer NN cord-354029-mp5r82g4 140 19 interface interface NN cord-354029-mp5r82g4 140 20 . . . cord-354029-mp5r82g4 141 1 HA1 HA1 NNP cord-354029-mp5r82g4 141 2 acts act VBZ cord-354029-mp5r82g4 141 3 as as IN cord-354029-mp5r82g4 141 4 a a DT cord-354029-mp5r82g4 141 5 clamp clamp NN cord-354029-mp5r82g4 141 6 to to TO cord-354029-mp5r82g4 141 7 hold hold VB cord-354029-mp5r82g4 141 8 HA2 HA2 NNP cord-354029-mp5r82g4 141 9 in in IN cord-354029-mp5r82g4 141 10 a a DT cord-354029-mp5r82g4 141 11 metastable metastable JJ cord-354029-mp5r82g4 141 12 state state NN cord-354029-mp5r82g4 141 13 . . . cord-354029-mp5r82g4 142 1 HA2 HA2 NNP cord-354029-mp5r82g4 142 2 is be VBZ cord-354029-mp5r82g4 142 3 largely largely RB cord-354029-mp5r82g4 142 4 shielded shield VBN cord-354029-mp5r82g4 142 5 by by IN cord-354029-mp5r82g4 142 6 HA1 HA1 NNP cord-354029-mp5r82g4 142 7 . . . cord-354029-mp5r82g4 143 1 To to TO cord-354029-mp5r82g4 143 2 illuminate illuminate VB cord-354029-mp5r82g4 143 3 the the DT cord-354029-mp5r82g4 143 4 HA2 HA2 NNP cord-354029-mp5r82g4 143 5 core core NN cord-354029-mp5r82g4 143 6 , , , cord-354029-mp5r82g4 143 7 we -PRON- PRP cord-354029-mp5r82g4 143 8 have have VBP cord-354029-mp5r82g4 143 9 cartooned cartoon VBN cord-354029-mp5r82g4 143 10 the the DT cord-354029-mp5r82g4 143 11 portion portion NN cord-354029-mp5r82g4 143 12 of of IN cord-354029-mp5r82g4 143 13 HA1 HA1 NNP cord-354029-mp5r82g4 143 14 that that WDT cord-354029-mp5r82g4 143 15 covers cover VBZ cord-354029-mp5r82g4 143 16 HA2 HA2 NNP cord-354029-mp5r82g4 143 17 as as IN cord-354029-mp5r82g4 143 18 a a DT cord-354029-mp5r82g4 143 19 simple simple JJ cord-354029-mp5r82g4 143 20 ( ( -LRB- cord-354029-mp5r82g4 143 21 gray gray JJ cord-354029-mp5r82g4 143 22 ) ) -RRB- cord-354029-mp5r82g4 143 23 line line NN cord-354029-mp5r82g4 143 24 . . . cord-354029-mp5r82g4 144 1 B b NN cord-354029-mp5r82g4 145 1 On on IN cord-354029-mp5r82g4 145 2 exposure exposure NN cord-354029-mp5r82g4 145 3 to to IN cord-354029-mp5r82g4 145 4 low low JJ cord-354029-mp5r82g4 145 5 pH ph NN cord-354029-mp5r82g4 145 6 , , , cord-354029-mp5r82g4 145 7 the the DT cord-354029-mp5r82g4 145 8 HA1 HA1 NNP cord-354029-mp5r82g4 145 9 headgroups headgroups NNP cord-354029-mp5r82g4 145 10 separate separate JJ cord-354029-mp5r82g4 145 11 , , , cord-354029-mp5r82g4 145 12 allowing allow VBG cord-354029-mp5r82g4 145 13 expulsion expulsion NN cord-354029-mp5r82g4 145 14 of of IN cord-354029-mp5r82g4 145 15 the the DT cord-354029-mp5r82g4 145 16 fusion fusion NN cord-354029-mp5r82g4 145 17 peptide peptide NN cord-354029-mp5r82g4 145 18 . . . cord-354029-mp5r82g4 146 1 C C NNP cord-354029-mp5r82g4 146 2 A a DT cord-354029-mp5r82g4 146 3 loop loop NN cord-354029-mp5r82g4 146 4 - - HYPH cord-354029-mp5r82g4 146 5 to to IN cord-354029-mp5r82g4 146 6 - - HYPH cord-354029-mp5r82g4 146 7 helix helix NN cord-354029-mp5r82g4 146 8 transition transition NN cord-354029-mp5r82g4 146 9 causes cause VBZ cord-354029-mp5r82g4 146 10 the the DT cord-354029-mp5r82g4 146 11 fusion fusion NN cord-354029-mp5r82g4 146 12 peptide peptide NN cord-354029-mp5r82g4 146 13 to to TO cord-354029-mp5r82g4 146 14 be be VB cord-354029-mp5r82g4 146 15 repositioned reposition VBN cord-354029-mp5r82g4 146 16 to to IN cord-354029-mp5r82g4 146 17 one one CD cord-354029-mp5r82g4 146 18 end end NN cord-354029-mp5r82g4 146 19 of of IN cord-354029-mp5r82g4 146 20 HA2 HA2 NNP cord-354029-mp5r82g4 146 21 , , , cord-354029-mp5r82g4 146 22 where where WRB cord-354029-mp5r82g4 146 23 it -PRON- PRP cord-354029-mp5r82g4 146 24 can can MD cord-354029-mp5r82g4 146 25 bind bind VB cord-354029-mp5r82g4 146 26 to to IN cord-354029-mp5r82g4 146 27 the the DT cord-354029-mp5r82g4 146 28 target target NN cord-354029-mp5r82g4 146 29 membrane membrane NN cord-354029-mp5r82g4 146 30 . . . cord-354029-mp5r82g4 147 1 D D NNP cord-354029-mp5r82g4 148 1 A a DT cord-354029-mp5r82g4 148 2 helix helix NN cord-354029-mp5r82g4 148 3 - - HYPH cord-354029-mp5r82g4 148 4 to to IN cord-354029-mp5r82g4 148 5 - - HYPH cord-354029-mp5r82g4 148 6 loop loop NN cord-354029-mp5r82g4 148 7 transition transition NN cord-354029-mp5r82g4 148 8 causes cause VBZ cord-354029-mp5r82g4 148 9 the the DT cord-354029-mp5r82g4 148 10 C C NNP cord-354029-mp5r82g4 148 11 - - HYPH cord-354029-mp5r82g4 148 12 terminal terminal NN cord-354029-mp5r82g4 148 13 helix helix NN cord-354029-mp5r82g4 148 14 and and CC cord-354029-mp5r82g4 148 15 the the DT cord-354029-mp5r82g4 148 16 C C NNP cord-354029-mp5r82g4 148 17 - - HYPH cord-354029-mp5r82g4 148 18 terminal terminal NN cord-354029-mp5r82g4 148 19 extended extended JJ cord-354029-mp5r82g4 148 20 region region NN cord-354029-mp5r82g4 148 21 to to TO cord-354029-mp5r82g4 148 22 reverse reverse VB cord-354029-mp5r82g4 148 23 direction direction NN cord-354029-mp5r82g4 148 24 and and CC cord-354029-mp5r82g4 148 25 bind bind VB cord-354029-mp5r82g4 148 26 to to IN cord-354029-mp5r82g4 148 27 the the DT cord-354029-mp5r82g4 148 28 grooves groove NNS cord-354029-mp5r82g4 148 29 of of IN cord-354029-mp5r82g4 148 30 the the DT cord-354029-mp5r82g4 148 31 coiled coil VBN cord-354029-mp5r82g4 148 32 - - HYPH cord-354029-mp5r82g4 148 33 coil coil NN cord-354029-mp5r82g4 148 34 in in IN cord-354029-mp5r82g4 148 35 an an DT cord-354029-mp5r82g4 148 36 antiparallel antiparallel JJ cord-354029-mp5r82g4 148 37 orientation orientation NN cord-354029-mp5r82g4 148 38 On on IN cord-354029-mp5r82g4 148 39 exposure exposure NN cord-354029-mp5r82g4 148 40 to to IN cord-354029-mp5r82g4 148 41 low low JJ cord-354029-mp5r82g4 148 42 pH ph NN cord-354029-mp5r82g4 148 43 , , , cord-354029-mp5r82g4 148 44 HA HA NNP cord-354029-mp5r82g4 148 45 undergoes undergo VBZ cord-354029-mp5r82g4 148 46 dramatic dramatic JJ cord-354029-mp5r82g4 148 47 conformational conformational JJ cord-354029-mp5r82g4 148 48 changes change NNS cord-354029-mp5r82g4 148 49 . . . cord-354029-mp5r82g4 149 1 The the DT cord-354029-mp5r82g4 149 2 globular globular JJ cord-354029-mp5r82g4 149 3 head head NN cord-354029-mp5r82g4 149 4 domains domain NNS cord-354029-mp5r82g4 149 5 separate separate JJ cord-354029-mp5r82g4 149 6 , , , cord-354029-mp5r82g4 149 7 releasing release VBG cord-354029-mp5r82g4 149 8 the the DT cord-354029-mp5r82g4 149 9 clamp clamp NN cord-354029-mp5r82g4 149 10 that that WDT cord-354029-mp5r82g4 149 11 holds hold VBZ cord-354029-mp5r82g4 149 12 HA2 HA2 NNP cord-354029-mp5r82g4 149 13 in in IN cord-354029-mp5r82g4 149 14 its -PRON- PRP$ cord-354029-mp5r82g4 149 15 metastable metastable JJ cord-354029-mp5r82g4 149 16 state state NN cord-354029-mp5r82g4 149 17 ( ( -LRB- cord-354029-mp5r82g4 149 18 Fig Fig NNP cord-354029-mp5r82g4 149 19 . . . cord-354029-mp5r82g4 149 20 2B 2b CD cord-354029-mp5r82g4 149 21 ) ) -RRB- cord-354029-mp5r82g4 149 22 . . . cord-354029-mp5r82g4 150 1 As as IN cord-354029-mp5r82g4 150 2 a a DT cord-354029-mp5r82g4 150 3 result result NN cord-354029-mp5r82g4 150 4 , , , cord-354029-mp5r82g4 150 5 the the DT cord-354029-mp5r82g4 150 6 fusion fusion NN cord-354029-mp5r82g4 150 7 peptide peptide NN cord-354029-mp5r82g4 150 8 is be VBZ cord-354029-mp5r82g4 150 9 exposed expose VBN cord-354029-mp5r82g4 151 1 ( ( -LRB- cord-354029-mp5r82g4 151 2 Fig Fig NNP cord-354029-mp5r82g4 151 3 . . . cord-354029-mp5r82g4 151 4 2C 2C NNP cord-354029-mp5r82g4 151 5 , , , cord-354029-mp5r82g4 151 6 red red NNP cord-354029-mp5r82g4 151 7 ) ) -RRB- cord-354029-mp5r82g4 151 8 at at IN cord-354029-mp5r82g4 151 9 the the DT cord-354029-mp5r82g4 151 10 top top NN cord-354029-mp5r82g4 151 11 of of IN cord-354029-mp5r82g4 151 12 an an DT cord-354029-mp5r82g4 151 13 extended extended JJ cord-354029-mp5r82g4 151 14 triple triple RB cord-354029-mp5r82g4 151 15 - - HYPH cord-354029-mp5r82g4 151 16 stranded stranded JJ cord-354029-mp5r82g4 151 17 coiled coiled JJ cord-354029-mp5r82g4 151 18 - - HYPH cord-354029-mp5r82g4 151 19 coil coil NN cord-354029-mp5r82g4 151 20 , , , cord-354029-mp5r82g4 151 21 in in IN cord-354029-mp5r82g4 151 22 a a DT cord-354029-mp5r82g4 151 23 position position NN cord-354029-mp5r82g4 151 24 where where WRB cord-354029-mp5r82g4 151 25 it -PRON- PRP cord-354029-mp5r82g4 151 26 can can MD cord-354029-mp5r82g4 151 27 interact interact VB cord-354029-mp5r82g4 151 28 with with IN cord-354029-mp5r82g4 151 29 the the DT cord-354029-mp5r82g4 151 30 target target NN cord-354029-mp5r82g4 151 31 membrane membrane NN cord-354029-mp5r82g4 151 32 . . . cord-354029-mp5r82g4 152 1 A a DT cord-354029-mp5r82g4 152 2 helix helix NN cord-354029-mp5r82g4 152 3 - - HYPH cord-354029-mp5r82g4 152 4 to to IN cord-354029-mp5r82g4 152 5 - - HYPH cord-354029-mp5r82g4 152 6 loop loop NN cord-354029-mp5r82g4 152 7 transition transition NN cord-354029-mp5r82g4 152 8 causes cause VBZ cord-354029-mp5r82g4 152 9 a a DT cord-354029-mp5r82g4 152 10 short short JJ cord-354029-mp5r82g4 152 11 helix helix NN cord-354029-mp5r82g4 153 1 ( ( -LRB- cord-354029-mp5r82g4 153 2 Fig Fig NNP cord-354029-mp5r82g4 153 3 . . . cord-354029-mp5r82g4 153 4 2D 2D NNP cord-354029-mp5r82g4 153 5 , , , cord-354029-mp5r82g4 153 6 green green NNP cord-354029-mp5r82g4 153 7 ) ) -RRB- cord-354029-mp5r82g4 153 8 and and CC cord-354029-mp5r82g4 153 9 the the DT cord-354029-mp5r82g4 153 10 C C NNP cord-354029-mp5r82g4 153 11 - - HYPH cord-354029-mp5r82g4 153 12 terminal terminal NN cord-354029-mp5r82g4 153 13 extended extended JJ cord-354029-mp5r82g4 153 14 region region NN cord-354029-mp5r82g4 153 15 ( ( -LRB- cord-354029-mp5r82g4 153 16 yellow yellow NNP cord-354029-mp5r82g4 153 17 ) ) -RRB- cord-354029-mp5r82g4 153 18 to to TO cord-354029-mp5r82g4 153 19 flip flip VB cord-354029-mp5r82g4 153 20 up up RP cord-354029-mp5r82g4 153 21 and and CC cord-354029-mp5r82g4 153 22 run run VB cord-354029-mp5r82g4 153 23 antiparallel antiparallel RB cord-354029-mp5r82g4 153 24 to to IN cord-354029-mp5r82g4 153 25 the the DT cord-354029-mp5r82g4 153 26 central central JJ cord-354029-mp5r82g4 153 27 coiled coil VBN cord-354029-mp5r82g4 153 28 - - HYPH cord-354029-mp5r82g4 153 29 coil coil NN cord-354029-mp5r82g4 153 30 ( ( -LRB- cord-354029-mp5r82g4 153 31 Bullough Bullough NNP cord-354029-mp5r82g4 153 32 et et NNP cord-354029-mp5r82g4 153 33 al al NNP cord-354029-mp5r82g4 153 34 . . . cord-354029-mp5r82g4 153 35 1994 1994 CD cord-354029-mp5r82g4 153 36 ) ) -RRB- cord-354029-mp5r82g4 153 37 . . . cord-354029-mp5r82g4 154 1 As as IN cord-354029-mp5r82g4 154 2 a a DT cord-354029-mp5r82g4 154 3 result result NN cord-354029-mp5r82g4 154 4 , , , cord-354029-mp5r82g4 154 5 the the DT cord-354029-mp5r82g4 154 6 fusion fusion NN cord-354029-mp5r82g4 154 7 peptide peptide NN cord-354029-mp5r82g4 154 8 and and CC cord-354029-mp5r82g4 154 9 transmembrane transmembrane NN cord-354029-mp5r82g4 154 10 domain domain NN cord-354029-mp5r82g4 154 11 are be VBP cord-354029-mp5r82g4 154 12 brought bring VBN cord-354029-mp5r82g4 154 13 into into IN cord-354029-mp5r82g4 154 14 close close JJ cord-354029-mp5r82g4 154 15 proximity proximity NN cord-354029-mp5r82g4 154 16 at at IN cord-354029-mp5r82g4 154 17 the the DT cord-354029-mp5r82g4 154 18 same same JJ cord-354029-mp5r82g4 154 19 end end NN cord-354029-mp5r82g4 154 20 of of IN cord-354029-mp5r82g4 154 21 the the DT cord-354029-mp5r82g4 154 22 molecule molecule NN cord-354029-mp5r82g4 154 23 ( ( -LRB- cord-354029-mp5r82g4 154 24 Fig Fig NNP cord-354029-mp5r82g4 154 25 . . . cord-354029-mp5r82g4 154 26 2D 2D NNP cord-354029-mp5r82g4 154 27 ) ) -RRB- cord-354029-mp5r82g4 154 28 . . . cord-354029-mp5r82g4 155 1 Many many JJ cord-354029-mp5r82g4 155 2 regions region NNS cord-354029-mp5r82g4 155 3 of of IN cord-354029-mp5r82g4 155 4 HA HA NNP cord-354029-mp5r82g4 155 5 are be VBP cord-354029-mp5r82g4 155 6 important important JJ cord-354029-mp5r82g4 155 7 for for IN cord-354029-mp5r82g4 155 8 fusion fusion NN cord-354029-mp5r82g4 155 9 . . . cord-354029-mp5r82g4 156 1 The the DT cord-354029-mp5r82g4 156 2 fusion fusion NN cord-354029-mp5r82g4 156 3 peptide peptide NN cord-354029-mp5r82g4 156 4 is be VBZ cord-354029-mp5r82g4 156 5 critical critical JJ cord-354029-mp5r82g4 156 6 for for IN cord-354029-mp5r82g4 156 7 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 156 8 attachment attachment NN cord-354029-mp5r82g4 156 9 of of IN cord-354029-mp5r82g4 156 10 the the DT cord-354029-mp5r82g4 156 11 virus virus NN cord-354029-mp5r82g4 156 12 to to IN cord-354029-mp5r82g4 156 13 the the DT cord-354029-mp5r82g4 156 14 target target NN cord-354029-mp5r82g4 156 15 membrane membrane NN cord-354029-mp5r82g4 156 16 ( ( -LRB- cord-354029-mp5r82g4 156 17 Sect Sect NNP cord-354029-mp5r82g4 156 18 . . . cord-354029-mp5r82g4 157 1 6.1 6.1 CD cord-354029-mp5r82g4 157 2 ) ) -RRB- cord-354029-mp5r82g4 157 3 . . . cord-354029-mp5r82g4 158 1 Mutations mutation NNS cord-354029-mp5r82g4 158 2 that that WDT cord-354029-mp5r82g4 158 3 prevent prevent VBP cord-354029-mp5r82g4 158 4 ( ( -LRB- cord-354029-mp5r82g4 158 5 1 1 CD cord-354029-mp5r82g4 158 6 ) ) -RRB- cord-354029-mp5r82g4 158 7 globular globular JJ cord-354029-mp5r82g4 158 8 head head NN cord-354029-mp5r82g4 158 9 domain domain NN cord-354029-mp5r82g4 158 10 separation separation NN cord-354029-mp5r82g4 158 11 ( ( -LRB- cord-354029-mp5r82g4 158 12 Godley Godley NNP cord-354029-mp5r82g4 158 13 et et NNP cord-354029-mp5r82g4 158 14 al al NNP cord-354029-mp5r82g4 158 15 . . NNP cord-354029-mp5r82g4 158 16 1992 1992 CD cord-354029-mp5r82g4 158 17 ; ; : cord-354029-mp5r82g4 158 18 Kemble Kemble NNP cord-354029-mp5r82g4 158 19 et et NNP cord-354029-mp5r82g4 158 20 al al NNP cord-354029-mp5r82g4 158 21 . . NNP cord-354029-mp5r82g4 158 22 1992 1992 CD cord-354029-mp5r82g4 158 23 ) ) -RRB- cord-354029-mp5r82g4 158 24 , , , cord-354029-mp5r82g4 158 25 ( ( -LRB- cord-354029-mp5r82g4 158 26 2 2 LS cord-354029-mp5r82g4 158 27 ) ) -RRB- cord-354029-mp5r82g4 158 28 the the DT cord-354029-mp5r82g4 158 29 " " `` cord-354029-mp5r82g4 158 30 B b NN cord-354029-mp5r82g4 158 31 - - HYPH cord-354029-mp5r82g4 158 32 loop"-to loop"-to NN cord-354029-mp5r82g4 158 33 helix helix NN cord-354029-mp5r82g4 158 34 transition transition NN cord-354029-mp5r82g4 159 1 ( ( -LRB- cord-354029-mp5r82g4 159 2 Gruenke Gruenke NNP cord-354029-mp5r82g4 159 3 et et NNP cord-354029-mp5r82g4 159 4 al al NNP cord-354029-mp5r82g4 159 5 . . . cord-354029-mp5r82g4 160 1 2002 2002 CD cord-354029-mp5r82g4 160 2 ; ; : cord-354029-mp5r82g4 160 3 Qiao Qiao NNP cord-354029-mp5r82g4 160 4 et et FW cord-354029-mp5r82g4 160 5 al al NNP cord-354029-mp5r82g4 160 6 . . NNP cord-354029-mp5r82g4 160 7 1998 1998 CD cord-354029-mp5r82g4 160 8 ) ) -RRB- cord-354029-mp5r82g4 160 9 , , , cord-354029-mp5r82g4 160 10 or or CC cord-354029-mp5r82g4 160 11 ( ( -LRB- cord-354029-mp5r82g4 160 12 3 3 LS cord-354029-mp5r82g4 160 13 ) ) -RRB- cord-354029-mp5r82g4 160 14 the the DT cord-354029-mp5r82g4 160 15 C C NNP cord-354029-mp5r82g4 160 16 - - HYPH cord-354029-mp5r82g4 160 17 terminal terminal NN cord-354029-mp5r82g4 160 18 extended extended JJ cord-354029-mp5r82g4 160 19 region region NN cord-354029-mp5r82g4 160 20 from from IN cord-354029-mp5r82g4 160 21 packing pack VBG cord-354029-mp5r82g4 160 22 into into IN cord-354029-mp5r82g4 160 23 the the DT cord-354029-mp5r82g4 160 24 grooves groove NNS cord-354029-mp5r82g4 160 25 of of IN cord-354029-mp5r82g4 160 26 the the DT cord-354029-mp5r82g4 160 27 final final JJ cord-354029-mp5r82g4 160 28 coiled coil VBN cord-354029-mp5r82g4 160 29 - - HYPH cord-354029-mp5r82g4 160 30 coil coil NN cord-354029-mp5r82g4 160 31 ( ( -LRB- cord-354029-mp5r82g4 160 32 Borrego Borrego NNP cord-354029-mp5r82g4 160 33 - - HYPH cord-354029-mp5r82g4 160 34 Diaz Diaz NNP cord-354029-mp5r82g4 160 35 et et NNP cord-354029-mp5r82g4 160 36 al al NNP cord-354029-mp5r82g4 160 37 . . . cord-354029-mp5r82g4 161 1 2003 2003 CD cord-354029-mp5r82g4 161 2 ; ; : cord-354029-mp5r82g4 161 3 Park Park NNP cord-354029-mp5r82g4 161 4 et et FW cord-354029-mp5r82g4 161 5 al al NNP cord-354029-mp5r82g4 161 6 . . NNP cord-354029-mp5r82g4 161 7 2003 2003 CD cord-354029-mp5r82g4 161 8 ) ) -RRB- cord-354029-mp5r82g4 161 9 ablate ablate VB cord-354029-mp5r82g4 161 10 the the DT cord-354029-mp5r82g4 161 11 ability ability NN cord-354029-mp5r82g4 161 12 of of IN cord-354029-mp5r82g4 161 13 HA HA NNP cord-354029-mp5r82g4 161 14 to to TO cord-354029-mp5r82g4 161 15 reach reach VB cord-354029-mp5r82g4 161 16 the the DT cord-354029-mp5r82g4 161 17 lipid lipid NN cord-354029-mp5r82g4 161 18 mixing mix VBG cord-354029-mp5r82g4 161 19 stage stage NN cord-354029-mp5r82g4 161 20 of of IN cord-354029-mp5r82g4 161 21 fusion fusion NN cord-354029-mp5r82g4 161 22 . . . cord-354029-mp5r82g4 162 1 In in IN cord-354029-mp5r82g4 162 2 our -PRON- PRP$ cord-354029-mp5r82g4 162 3 model model NN cord-354029-mp5r82g4 162 4 ( ( -LRB- cord-354029-mp5r82g4 162 5 Gruenke Gruenke NNP cord-354029-mp5r82g4 162 6 et et NNP cord-354029-mp5r82g4 162 7 al al NNP cord-354029-mp5r82g4 162 8 . . . cord-354029-mp5r82g4 162 9 2002 2002 CD cord-354029-mp5r82g4 162 10 ) ) -RRB- cord-354029-mp5r82g4 162 11 , , , cord-354029-mp5r82g4 162 12 conversion conversion NN cord-354029-mp5r82g4 162 13 of of IN cord-354029-mp5r82g4 162 14 HA HA NNP cord-354029-mp5r82g4 162 15 to to IN cord-354029-mp5r82g4 162 16 a a DT cord-354029-mp5r82g4 162 17 prehairpin prehairpin NN cord-354029-mp5r82g4 162 18 intermediate intermediate JJ cord-354029-mp5r82g4 162 19 ( ( -LRB- cord-354029-mp5r82g4 162 20 Fig Fig NNP cord-354029-mp5r82g4 162 21 . . . cord-354029-mp5r82g4 162 22 2C 2C NNP cord-354029-mp5r82g4 162 23 ) ) -RRB- cord-354029-mp5r82g4 162 24 allows allow VBZ cord-354029-mp5r82g4 162 25 HA HA NNP cord-354029-mp5r82g4 162 26 to to TO cord-354029-mp5r82g4 162 27 bind bind VB cord-354029-mp5r82g4 162 28 to to IN cord-354029-mp5r82g4 162 29 the the DT cord-354029-mp5r82g4 162 30 target target NN cord-354029-mp5r82g4 162 31 membrane membrane NN cord-354029-mp5r82g4 162 32 . . . cord-354029-mp5r82g4 163 1 Further further JJ cord-354029-mp5r82g4 163 2 conversion conversion NN cord-354029-mp5r82g4 163 3 to to IN cord-354029-mp5r82g4 163 4 the the DT cord-354029-mp5r82g4 163 5 hairpin hairpin JJ cord-354029-mp5r82g4 163 6 structure structure NN cord-354029-mp5r82g4 163 7 ( ( -LRB- cord-354029-mp5r82g4 163 8 Fig Fig NNP cord-354029-mp5r82g4 163 9 . . . cord-354029-mp5r82g4 163 10 2D 2D NNP cord-354029-mp5r82g4 163 11 ) ) -RRB- cord-354029-mp5r82g4 163 12 then then RB cord-354029-mp5r82g4 163 13 drives drive VBZ cord-354029-mp5r82g4 163 14 the the DT cord-354029-mp5r82g4 163 15 formation formation NN cord-354029-mp5r82g4 163 16 and and CC cord-354029-mp5r82g4 163 17 opening opening NN cord-354029-mp5r82g4 163 18 of of IN cord-354029-mp5r82g4 163 19 a a DT cord-354029-mp5r82g4 163 20 fusion fusion NN cord-354029-mp5r82g4 163 21 pore pore NN cord-354029-mp5r82g4 163 22 . . . cord-354029-mp5r82g4 164 1 Like like IN cord-354029-mp5r82g4 164 2 influenza influenza NN cord-354029-mp5r82g4 164 3 HA HA NNP cord-354029-mp5r82g4 164 4 , , , cord-354029-mp5r82g4 164 5 HIV HIV NNP cord-354029-mp5r82g4 164 6 Env Env NNP cord-354029-mp5r82g4 164 7 is be VBZ cord-354029-mp5r82g4 164 8 synthesized synthesize VBN cord-354029-mp5r82g4 164 9 as as IN cord-354029-mp5r82g4 164 10 a a DT cord-354029-mp5r82g4 164 11 single single JJ cord-354029-mp5r82g4 164 12 - - HYPH cord-354029-mp5r82g4 164 13 chain chain NN cord-354029-mp5r82g4 164 14 precursor precursor NN cord-354029-mp5r82g4 164 15 and and CC cord-354029-mp5r82g4 164 16 cleaved cleave VBD cord-354029-mp5r82g4 164 17 during during IN cord-354029-mp5r82g4 164 18 biosynthesis biosynthesis NN cord-354029-mp5r82g4 164 19 to to TO cord-354029-mp5r82g4 164 20 yield yield VB cord-354029-mp5r82g4 164 21 gp120 gp120 NNP cord-354029-mp5r82g4 164 22 and and CC cord-354029-mp5r82g4 164 23 gp41 gp41 NN cord-354029-mp5r82g4 164 24 . . . cord-354029-mp5r82g4 165 1 Native native JJ cord-354029-mp5r82g4 165 2 ( ( -LRB- cord-354029-mp5r82g4 165 3 metastable metastable JJ cord-354029-mp5r82g4 165 4 ) ) -RRB- cord-354029-mp5r82g4 166 1 HIV HIV NNP cord-354029-mp5r82g4 166 2 Env Env NNP cord-354029-mp5r82g4 166 3 is be VBZ cord-354029-mp5r82g4 166 4 a a DT cord-354029-mp5r82g4 166 5 trimer trimer NN cord-354029-mp5r82g4 166 6 of of IN cord-354029-mp5r82g4 166 7 the the DT cord-354029-mp5r82g4 166 8 heterodimers heterodimer NNS cord-354029-mp5r82g4 166 9 of of IN cord-354029-mp5r82g4 166 10 gp120 gp120 NNP cord-354029-mp5r82g4 167 1 ( ( -LRB- cord-354029-mp5r82g4 167 2 the the DT cord-354029-mp5r82g4 167 3 receptor receptor NN cord-354029-mp5r82g4 167 4 binding bind VBG cord-354029-mp5r82g4 167 5 subunit subunit NN cord-354029-mp5r82g4 167 6 ) ) -RRB- cord-354029-mp5r82g4 167 7 and and CC cord-354029-mp5r82g4 167 8 gp41 gp41 NNP cord-354029-mp5r82g4 167 9 ( ( -LRB- cord-354029-mp5r82g4 167 10 the the DT cord-354029-mp5r82g4 167 11 fusion fusion NN cord-354029-mp5r82g4 167 12 subunit subunit NN cord-354029-mp5r82g4 167 13 ) ) -RRB- cord-354029-mp5r82g4 167 14 . . . cord-354029-mp5r82g4 168 1 Env Env NNP cord-354029-mp5r82g4 168 2 is be VBZ cord-354029-mp5r82g4 168 3 activated activate VBN cord-354029-mp5r82g4 168 4 for for IN cord-354029-mp5r82g4 168 5 fusion fusion NN cord-354029-mp5r82g4 168 6 ( ( -LRB- cord-354029-mp5r82g4 168 7 at at IN cord-354029-mp5r82g4 168 8 neutral neutral JJ cord-354029-mp5r82g4 168 9 pH pH NNP cord-354029-mp5r82g4 168 10 ) ) -RRB- cord-354029-mp5r82g4 168 11 after after IN cord-354029-mp5r82g4 168 12 sequential sequential JJ cord-354029-mp5r82g4 168 13 binding binding NN cord-354029-mp5r82g4 168 14 to to IN cord-354029-mp5r82g4 168 15 CD4 CD4 NNP cord-354029-mp5r82g4 168 16 and and CC cord-354029-mp5r82g4 168 17 a a DT cord-354029-mp5r82g4 168 18 coreceptor coreceptor NN cord-354029-mp5r82g4 168 19 ( ( -LRB- cord-354029-mp5r82g4 168 20 a a DT cord-354029-mp5r82g4 168 21 chemokine chemokine NN cord-354029-mp5r82g4 168 22 receptor receptor NN cord-354029-mp5r82g4 168 23 ) ) -RRB- cord-354029-mp5r82g4 168 24 . . . cord-354029-mp5r82g4 169 1 Binding bind VBG cord-354029-mp5r82g4 169 2 of of IN cord-354029-mp5r82g4 169 3 Env Env NNP cord-354029-mp5r82g4 169 4 to to IN cord-354029-mp5r82g4 169 5 CD4 CD4 NNP cord-354029-mp5r82g4 169 6 causes cause VBZ cord-354029-mp5r82g4 169 7 conformational conformational JJ cord-354029-mp5r82g4 169 8 changes change NNS cord-354029-mp5r82g4 169 9 in in IN cord-354029-mp5r82g4 169 10 Env Env NNP cord-354029-mp5r82g4 169 11 that that DT cord-354029-mp5r82g4 169 12 permit permit NN cord-354029-mp5r82g4 169 13 binding bind VBG cord-354029-mp5r82g4 169 14 to to IN cord-354029-mp5r82g4 169 15 the the DT cord-354029-mp5r82g4 169 16 coreceptor coreceptor NN cord-354029-mp5r82g4 169 17 . . . cord-354029-mp5r82g4 170 1 After after IN cord-354029-mp5r82g4 170 2 coreceptor coreceptor NN cord-354029-mp5r82g4 170 3 binding binding NN cord-354029-mp5r82g4 170 4 , , , cord-354029-mp5r82g4 170 5 additional additional JJ cord-354029-mp5r82g4 170 6 conformational conformational JJ cord-354029-mp5r82g4 170 7 changes change NNS cord-354029-mp5r82g4 170 8 occur occur VBP cord-354029-mp5r82g4 170 9 in in IN cord-354029-mp5r82g4 170 10 Env Env NNP cord-354029-mp5r82g4 170 11 that that DT cord-354029-mp5r82g4 170 12 lead lead NN cord-354029-mp5r82g4 170 13 to to IN cord-354029-mp5r82g4 170 14 fusion fusion NN cord-354029-mp5r82g4 171 1 ( ( -LRB- cord-354029-mp5r82g4 171 2 Eckert Eckert NNP cord-354029-mp5r82g4 171 3 and and CC cord-354029-mp5r82g4 171 4 Kim Kim NNP cord-354029-mp5r82g4 171 5 2001 2001 CD cord-354029-mp5r82g4 171 6 ) ) -RRB- cord-354029-mp5r82g4 171 7 . . . cord-354029-mp5r82g4 172 1 Crystal crystal NN cord-354029-mp5r82g4 172 2 structures structure NNS cord-354029-mp5r82g4 172 3 exist exist VBP cord-354029-mp5r82g4 172 4 for for IN cord-354029-mp5r82g4 172 5 the the DT cord-354029-mp5r82g4 172 6 core core NN cord-354029-mp5r82g4 172 7 of of IN cord-354029-mp5r82g4 172 8 the the DT cord-354029-mp5r82g4 172 9 gp120 gp120 NNP cord-354029-mp5r82g4 172 10 subunit subunit NN cord-354029-mp5r82g4 173 1 ( ( -LRB- cord-354029-mp5r82g4 173 2 Kwong Kwong NNP cord-354029-mp5r82g4 173 3 et et NNP cord-354029-mp5r82g4 173 4 al al NNP cord-354029-mp5r82g4 173 5 . . . cord-354029-mp5r82g4 173 6 1998 1998 CD cord-354029-mp5r82g4 173 7 ) ) -RRB- cord-354029-mp5r82g4 173 8 as as RB cord-354029-mp5r82g4 173 9 well well RB cord-354029-mp5r82g4 173 10 as as IN cord-354029-mp5r82g4 173 11 for for IN cord-354029-mp5r82g4 173 12 the the DT cord-354029-mp5r82g4 173 13 postfusion postfusion NN cord-354029-mp5r82g4 174 1 ( ( -LRB- cord-354029-mp5r82g4 174 2 Fig Fig NNP cord-354029-mp5r82g4 174 3 . . . cord-354029-mp5r82g4 174 4 3 3 CD cord-354029-mp5r82g4 174 5 , , , cord-354029-mp5r82g4 174 6 Step Step NNP cord-354029-mp5r82g4 174 7 6 6 CD cord-354029-mp5r82g4 174 8 ) ) -RRB- cord-354029-mp5r82g4 174 9 form form NN cord-354029-mp5r82g4 174 10 of of IN cord-354029-mp5r82g4 174 11 gp41 gp41 NNP cord-354029-mp5r82g4 175 1 ( ( -LRB- cord-354029-mp5r82g4 175 2 Chan Chan NNP cord-354029-mp5r82g4 175 3 et et NNP cord-354029-mp5r82g4 175 4 al al NNP cord-354029-mp5r82g4 175 5 . . . cord-354029-mp5r82g4 176 1 1997 1997 CD cord-354029-mp5r82g4 176 2 ; ; : cord-354029-mp5r82g4 176 3 Weissenhorn Weissenhorn NNP cord-354029-mp5r82g4 176 4 et et NNP cord-354029-mp5r82g4 176 5 al al NNP cord-354029-mp5r82g4 176 6 . . . cord-354029-mp5r82g4 176 7 1997 1997 CD cord-354029-mp5r82g4 176 8 ) ) -RRB- cord-354029-mp5r82g4 176 9 . . . cord-354029-mp5r82g4 177 1 However however RB cord-354029-mp5r82g4 177 2 , , , cord-354029-mp5r82g4 177 3 there there EX cord-354029-mp5r82g4 177 4 is be VBZ cord-354029-mp5r82g4 177 5 not not RB cord-354029-mp5r82g4 177 6 yet yet RB cord-354029-mp5r82g4 177 7 a a DT cord-354029-mp5r82g4 177 8 crystal crystal JJ cord-354029-mp5r82g4 177 9 structure structure NN cord-354029-mp5r82g4 177 10 of of IN cord-354029-mp5r82g4 177 11 the the DT cord-354029-mp5r82g4 177 12 native native JJ cord-354029-mp5r82g4 177 13 ( ( -LRB- cord-354029-mp5r82g4 177 14 metastable metastable JJ cord-354029-mp5r82g4 177 15 ) ) -RRB- cord-354029-mp5r82g4 177 16 Env env NN cord-354029-mp5r82g4 177 17 trimer trimer NN cord-354029-mp5r82g4 177 18 . . . cord-354029-mp5r82g4 178 1 Therefore therefore RB cord-354029-mp5r82g4 178 2 , , , cord-354029-mp5r82g4 178 3 a a DT cord-354029-mp5r82g4 178 4 detailed detailed JJ cord-354029-mp5r82g4 178 5 picture picture NN cord-354029-mp5r82g4 178 6 of of IN cord-354029-mp5r82g4 178 7 HIV HIV NNP cord-354029-mp5r82g4 178 8 Env Env NNP cord-354029-mp5r82g4 178 9 activation activation NN cord-354029-mp5r82g4 178 10 via via IN cord-354029-mp5r82g4 178 11 receptor receptor NN cord-354029-mp5r82g4 178 12 interaction interaction NN cord-354029-mp5r82g4 178 13 is be VBZ cord-354029-mp5r82g4 178 14 not not RB cord-354029-mp5r82g4 178 15 available available JJ cord-354029-mp5r82g4 178 16 . . . cord-354029-mp5r82g4 179 1 We -PRON- PRP cord-354029-mp5r82g4 179 2 presume presume VBP cord-354029-mp5r82g4 179 3 that that IN cord-354029-mp5r82g4 179 4 the the DT cord-354029-mp5r82g4 179 5 first first JJ cord-354029-mp5r82g4 179 6 steps step NNS cord-354029-mp5r82g4 179 7 of of IN cord-354029-mp5r82g4 179 8 Env Env NNP cord-354029-mp5r82g4 179 9 activation activation NN cord-354029-mp5r82g4 179 10 are be VBP cord-354029-mp5r82g4 179 11 separation separation NN cord-354029-mp5r82g4 179 12 of of IN cord-354029-mp5r82g4 179 13 the the DT cord-354029-mp5r82g4 179 14 globular globular JJ cord-354029-mp5r82g4 179 15 head head NN cord-354029-mp5r82g4 179 16 domains domain NNS cord-354029-mp5r82g4 179 17 , , , cord-354029-mp5r82g4 179 18 expulsion expulsion NN cord-354029-mp5r82g4 179 19 of of IN cord-354029-mp5r82g4 179 20 the the DT cord-354029-mp5r82g4 179 21 fusion fusion NN cord-354029-mp5r82g4 179 22 peptide peptide NN cord-354029-mp5r82g4 179 23 , , , cord-354029-mp5r82g4 179 24 and and CC cord-354029-mp5r82g4 179 25 extension extension NN cord-354029-mp5r82g4 179 26 of of IN cord-354029-mp5r82g4 179 27 gp41 gp41 NNP cord-354029-mp5r82g4 179 28 into into IN cord-354029-mp5r82g4 179 29 a a DT cord-354029-mp5r82g4 179 30 prehairpin prehairpin NN cord-354029-mp5r82g4 179 31 intermediate intermediate JJ cord-354029-mp5r82g4 179 32 ( ( -LRB- cord-354029-mp5r82g4 179 33 Fig Fig NNP cord-354029-mp5r82g4 179 34 . . . cord-354029-mp5r82g4 179 35 3 3 CD cord-354029-mp5r82g4 179 36 , , , cord-354029-mp5r82g4 179 37 Step step NN cord-354029-mp5r82g4 179 38 1 1 CD cord-354029-mp5r82g4 179 39 ) ) -RRB- cord-354029-mp5r82g4 179 40 . . . cord-354029-mp5r82g4 180 1 Several several JJ cord-354029-mp5r82g4 180 2 lines line NNS cord-354029-mp5r82g4 180 3 of of IN cord-354029-mp5r82g4 180 4 evidence evidence NN cord-354029-mp5r82g4 180 5 indicate indicate VBP cord-354029-mp5r82g4 180 6 the the DT cord-354029-mp5r82g4 180 7 existence existence NN cord-354029-mp5r82g4 180 8 of of IN cord-354029-mp5r82g4 180 9 the the DT cord-354029-mp5r82g4 180 10 prehairpin prehairpin NNP cord-354029-mp5r82g4 180 11 intermediate intermediate JJ cord-354029-mp5r82g4 180 12 . . . cord-354029-mp5r82g4 181 1 For for IN cord-354029-mp5r82g4 181 2 example example NN cord-354029-mp5r82g4 181 3 , , , cord-354029-mp5r82g4 181 4 peptide peptide NN cord-354029-mp5r82g4 181 5 analogs analog NNS cord-354029-mp5r82g4 181 6 of of IN cord-354029-mp5r82g4 181 7 the the DT cord-354029-mp5r82g4 181 8 C C NNP cord-354029-mp5r82g4 181 9 - - HYPH cord-354029-mp5r82g4 181 10 terminal terminal NN cord-354029-mp5r82g4 181 11 helix helix NN cord-354029-mp5r82g4 182 1 ( ( -LRB- cord-354029-mp5r82g4 182 2 Fig Fig NNP cord-354029-mp5r82g4 182 3 . . . cord-354029-mp5r82g4 182 4 3 3 CD cord-354029-mp5r82g4 182 5 , , , cord-354029-mp5r82g4 182 6 green green JJ cord-354029-mp5r82g4 182 7 ) ) -RRB- cord-354029-mp5r82g4 182 8 strongly strongly RB cord-354029-mp5r82g4 182 9 inhibit inhibit VB cord-354029-mp5r82g4 182 10 HIV HIV NNP cord-354029-mp5r82g4 182 11 fusion fusion NN cord-354029-mp5r82g4 182 12 and and CC cord-354029-mp5r82g4 182 13 infection infection NN cord-354029-mp5r82g4 182 14 ( ( -LRB- cord-354029-mp5r82g4 182 15 Chan Chan NNP cord-354029-mp5r82g4 182 16 and and CC cord-354029-mp5r82g4 182 17 Kim Kim NNP cord-354029-mp5r82g4 182 18 1998 1998 CD cord-354029-mp5r82g4 182 19 ; ; : cord-354029-mp5r82g4 182 20 Kilby Kilby NNP cord-354029-mp5r82g4 182 21 et et NNP cord-354029-mp5r82g4 182 22 al al NNP cord-354029-mp5r82g4 182 23 . . . cord-354029-mp5r82g4 182 24 1998 1998 CD cord-354029-mp5r82g4 182 25 ) ) -RRB- cord-354029-mp5r82g4 182 26 . . . cord-354029-mp5r82g4 183 1 Also also RB cord-354029-mp5r82g4 183 2 , , , cord-354029-mp5r82g4 183 3 a a DT cord-354029-mp5r82g4 183 4 synthetic synthetic JJ cord-354029-mp5r82g4 183 5 peptide peptide NN cord-354029-mp5r82g4 183 6 corresponding correspond VBG cord-354029-mp5r82g4 183 7 to to IN cord-354029-mp5r82g4 183 8 the the DT cord-354029-mp5r82g4 183 9 C C NNP cord-354029-mp5r82g4 183 10 - - HYPH cord-354029-mp5r82g4 183 11 terminal terminal NN cord-354029-mp5r82g4 183 12 helix helix NN cord-354029-mp5r82g4 183 13 coimmunoprecipitates coimmunoprecipitate NNS cord-354029-mp5r82g4 183 14 with with IN cord-354029-mp5r82g4 183 15 HIV HIV NNP cord-354029-mp5r82g4 183 16 Env Env NNP cord-354029-mp5r82g4 183 17 after after IN cord-354029-mp5r82g4 183 18 engagement engagement NN cord-354029-mp5r82g4 183 19 of of IN cord-354029-mp5r82g4 183 20 receptors receptor NNS cord-354029-mp5r82g4 183 21 ( ( -LRB- cord-354029-mp5r82g4 183 22 Furuta Furuta NNP cord-354029-mp5r82g4 183 23 et et FW cord-354029-mp5r82g4 183 24 al al NNP cord-354029-mp5r82g4 183 25 . . . cord-354029-mp5r82g4 183 26 1998 1998 CD cord-354029-mp5r82g4 183 27 ; ; : cord-354029-mp5r82g4 183 28 He -PRON- PRP cord-354029-mp5r82g4 183 29 et et FW cord-354029-mp5r82g4 183 30 al al NNP cord-354029-mp5r82g4 183 31 . . NNP cord-354029-mp5r82g4 183 32 2003 2003 CD cord-354029-mp5r82g4 183 33 ) ) -RRB- cord-354029-mp5r82g4 183 34 . . . cord-354029-mp5r82g4 184 1 The the DT cord-354029-mp5r82g4 184 2 C C NNP cord-354029-mp5r82g4 184 3 - - HYPH cord-354029-mp5r82g4 184 4 terminal terminal NN cord-354029-mp5r82g4 184 5 helix helix NN cord-354029-mp5r82g4 184 6 then then RB cord-354029-mp5r82g4 184 7 packs pack VBZ cord-354029-mp5r82g4 184 8 , , , cord-354029-mp5r82g4 184 9 in in IN cord-354029-mp5r82g4 184 10 an an DT cord-354029-mp5r82g4 184 11 antiparallel antiparallel JJ cord-354029-mp5r82g4 184 12 fashion fashion NN cord-354029-mp5r82g4 184 13 , , , cord-354029-mp5r82g4 184 14 into into IN cord-354029-mp5r82g4 184 15 the the DT cord-354029-mp5r82g4 184 16 groove groove NN cord-354029-mp5r82g4 184 17 of of IN cord-354029-mp5r82g4 184 18 the the DT cord-354029-mp5r82g4 184 19 N n CD cord-354029-mp5r82g4 184 20 - - HYPH cord-354029-mp5r82g4 184 21 terminal terminal NN cord-354029-mp5r82g4 184 22 coiled coil VBN cord-354029-mp5r82g4 184 23 - - HYPH cord-354029-mp5r82g4 184 24 coil coil NN cord-354029-mp5r82g4 184 25 ( ( -LRB- cord-354029-mp5r82g4 184 26 Fig Fig NNP cord-354029-mp5r82g4 184 27 . . . cord-354029-mp5r82g4 184 28 3 3 CD cord-354029-mp5r82g4 184 29 , , , cord-354029-mp5r82g4 184 30 Step step NN cord-354029-mp5r82g4 184 31 5 5 CD cord-354029-mp5r82g4 184 32 ) ) -RRB- cord-354029-mp5r82g4 184 33 . . . cord-354029-mp5r82g4 185 1 Because because IN cord-354029-mp5r82g4 185 2 the the DT cord-354029-mp5r82g4 185 3 C c NN cord-354029-mp5r82g4 185 4 - - HYPH cord-354029-mp5r82g4 185 5 terminal terminal NN cord-354029-mp5r82g4 185 6 helices helix NNS cord-354029-mp5r82g4 185 7 of of IN cord-354029-mp5r82g4 185 8 gp41 gp41 NNP cord-354029-mp5r82g4 185 9 extend extend VBP cord-354029-mp5r82g4 185 10 along along IN cord-354029-mp5r82g4 185 11 the the DT cord-354029-mp5r82g4 185 12 entire entire JJ cord-354029-mp5r82g4 185 13 length length NN cord-354029-mp5r82g4 185 14 of of IN cord-354029-mp5r82g4 185 15 the the DT cord-354029-mp5r82g4 185 16 N n CD cord-354029-mp5r82g4 185 17 - - HYPH cord-354029-mp5r82g4 185 18 terminal terminal NN cord-354029-mp5r82g4 185 19 coiled coil VBN cord-354029-mp5r82g4 185 20 - - HYPH cord-354029-mp5r82g4 185 21 coil coil NN cord-354029-mp5r82g4 185 22 , , , cord-354029-mp5r82g4 185 23 this this DT cord-354029-mp5r82g4 185 24 packing packing NN cord-354029-mp5r82g4 185 25 would would MD cord-354029-mp5r82g4 185 26 bring bring VB cord-354029-mp5r82g4 185 27 the the DT cord-354029-mp5r82g4 185 28 fusion fusion NN cord-354029-mp5r82g4 185 29 peptide peptide NN cord-354029-mp5r82g4 185 30 and and CC cord-354029-mp5r82g4 185 31 transmembrane transmembrane NN cord-354029-mp5r82g4 185 32 domain domain NN cord-354029-mp5r82g4 185 33 very very RB cord-354029-mp5r82g4 185 34 close close JJ cord-354029-mp5r82g4 185 35 together together RB cord-354029-mp5r82g4 185 36 . . . cord-354029-mp5r82g4 186 1 The the DT cord-354029-mp5r82g4 186 2 transition transition NN cord-354029-mp5r82g4 186 3 to to IN cord-354029-mp5r82g4 186 4 the the DT cord-354029-mp5r82g4 186 5 six six CD cord-354029-mp5r82g4 186 6 - - HYPH cord-354029-mp5r82g4 186 7 helix helix NN cord-354029-mp5r82g4 186 8 bundle bundle NN cord-354029-mp5r82g4 186 9 drives drive VBZ cord-354029-mp5r82g4 186 10 membrane membrane NN cord-354029-mp5r82g4 186 11 merger merger NN cord-354029-mp5r82g4 186 12 ( ( -LRB- cord-354029-mp5r82g4 186 13 Melikyan Melikyan NNP cord-354029-mp5r82g4 186 14 et et NNP cord-354029-mp5r82g4 186 15 al al NNP cord-354029-mp5r82g4 186 16 . . NNP cord-354029-mp5r82g4 186 17 2000a 2000a CD cord-354029-mp5r82g4 186 18 ) ) -RRB- cord-354029-mp5r82g4 186 19 . . . cord-354029-mp5r82g4 187 1 Moreover moreover RB cord-354029-mp5r82g4 187 2 , , , cord-354029-mp5r82g4 187 3 complete complete VB cord-354029-mp5r82g4 187 4 six six CD cord-354029-mp5r82g4 187 5 - - HYPH cord-354029-mp5r82g4 187 6 helix helix NN cord-354029-mp5r82g4 187 7 bundles bundle NNS cord-354029-mp5r82g4 187 8 are be VBP cord-354029-mp5r82g4 187 9 needed need VBN cord-354029-mp5r82g4 187 10 to to TO cord-354029-mp5r82g4 187 11 form form VB cord-354029-mp5r82g4 187 12 " " `` cord-354029-mp5r82g4 187 13 robust robust JJ cord-354029-mp5r82g4 187 14 " " '' cord-354029-mp5r82g4 187 15 fusion fusion NN cord-354029-mp5r82g4 187 16 pores pore NNS cord-354029-mp5r82g4 187 17 . . . cord-354029-mp5r82g4 188 1 As as IN cord-354029-mp5r82g4 188 2 mentioned mention VBN cord-354029-mp5r82g4 188 3 above above RB cord-354029-mp5r82g4 188 4 , , , cord-354029-mp5r82g4 188 5 HIV HIV NNP cord-354029-mp5r82g4 188 6 studies study NNS cord-354029-mp5r82g4 188 7 , , , cord-354029-mp5r82g4 188 8 primarily primarily RB cord-354029-mp5r82g4 188 9 using use VBG cord-354029-mp5r82g4 188 10 epitope epitope NN cord-354029-mp5r82g4 188 11 accessibility accessibility NN cord-354029-mp5r82g4 188 12 assays assay NNS cord-354029-mp5r82g4 188 13 , , , cord-354029-mp5r82g4 188 14 have have VBP cord-354029-mp5r82g4 188 15 indicated indicate VBN cord-354029-mp5r82g4 188 16 that that IN cord-354029-mp5r82g4 188 17 engagement engagement NN cord-354029-mp5r82g4 188 18 of of IN cord-354029-mp5r82g4 188 19 HIV HIV NNP cord-354029-mp5r82g4 188 20 receptors receptor NNS cord-354029-mp5r82g4 188 21 induces induce VBZ cord-354029-mp5r82g4 188 22 con- con- NN cord-354029-mp5r82g4 188 23 Target Target NNP cord-354029-mp5r82g4 188 24 cell cell NN cord-354029-mp5r82g4 188 25 receptors receptor NNS cord-354029-mp5r82g4 188 26 are be VBP cord-354029-mp5r82g4 188 27 not not RB cord-354029-mp5r82g4 188 28 pictured picture VBN cord-354029-mp5r82g4 188 29 in in IN cord-354029-mp5r82g4 188 30 this this DT cord-354029-mp5r82g4 188 31 model model NN cord-354029-mp5r82g4 188 32 . . . cord-354029-mp5r82g4 189 1 On on IN cord-354029-mp5r82g4 189 2 exposure exposure NN cord-354029-mp5r82g4 189 3 to to IN cord-354029-mp5r82g4 189 4 receptor receptor NN cord-354029-mp5r82g4 189 5 and and CC cord-354029-mp5r82g4 189 6 coreceptor coreceptor NN cord-354029-mp5r82g4 189 7 at at IN cord-354029-mp5r82g4 189 8 T T NNP cord-354029-mp5r82g4 189 9 ! ! . cord-354029-mp5r82g4 190 1 22C 22C NNP cord-354029-mp5r82g4 190 2 and and CC cord-354029-mp5r82g4 190 3 neutral neutral JJ cord-354029-mp5r82g4 190 4 pH ph NN cord-354029-mp5r82g4 191 1 , , , cord-354029-mp5r82g4 191 2 Env Env NNP cord-354029-mp5r82g4 191 3 undergoes undergo VBZ cord-354029-mp5r82g4 191 4 conformational conformational JJ cord-354029-mp5r82g4 191 5 changes change NNS cord-354029-mp5r82g4 191 6 that that WDT cord-354029-mp5r82g4 191 7 result result VBP cord-354029-mp5r82g4 191 8 in in IN cord-354029-mp5r82g4 191 9 exposure exposure NN cord-354029-mp5r82g4 191 10 of of IN cord-354029-mp5r82g4 191 11 the the DT cord-354029-mp5r82g4 191 12 fusion fusion NN cord-354029-mp5r82g4 191 13 peptides peptide NNS cord-354029-mp5r82g4 191 14 ( ( -LRB- cord-354029-mp5r82g4 191 15 Step Step NNP cord-354029-mp5r82g4 191 16 1 1 CD cord-354029-mp5r82g4 191 17 ) ) -RRB- cord-354029-mp5r82g4 191 18 , , , cord-354029-mp5r82g4 191 19 which which WDT cord-354029-mp5r82g4 191 20 then then RB cord-354029-mp5r82g4 191 21 insert insert VBP cord-354029-mp5r82g4 191 22 into into IN cord-354029-mp5r82g4 191 23 the the DT cord-354029-mp5r82g4 191 24 target target NN cord-354029-mp5r82g4 191 25 membrane membrane NN cord-354029-mp5r82g4 191 26 ( ( -LRB- cord-354029-mp5r82g4 191 27 Step Step NNP cord-354029-mp5r82g4 191 28 2 2 CD cord-354029-mp5r82g4 191 29 ) ) -RRB- cord-354029-mp5r82g4 191 30 . . . cord-354029-mp5r82g4 192 1 Multiple multiple JJ cord-354029-mp5r82g4 192 2 Envs Envs NNP cord-354029-mp5r82g4 192 3 may may MD cord-354029-mp5r82g4 192 4 cluster cluster VB cord-354029-mp5r82g4 192 5 ( ( -LRB- cord-354029-mp5r82g4 192 6 Step Step NNP cord-354029-mp5r82g4 192 7 3 3 CD cord-354029-mp5r82g4 192 8 ) ) -RRB- cord-354029-mp5r82g4 192 9 to to TO cord-354029-mp5r82g4 192 10 form form VB cord-354029-mp5r82g4 192 11 a a DT cord-354029-mp5r82g4 192 12 fusion fusion NN cord-354029-mp5r82g4 192 13 site site NN cord-354029-mp5r82g4 192 14 . . . cord-354029-mp5r82g4 193 1 Additional additional JJ cord-354029-mp5r82g4 193 2 conformational conformational JJ cord-354029-mp5r82g4 193 3 changes change NNS cord-354029-mp5r82g4 193 4 ( ( -LRB- cord-354029-mp5r82g4 193 5 Steps step NNS cord-354029-mp5r82g4 193 6 4 4 CD cord-354029-mp5r82g4 193 7 and and CC cord-354029-mp5r82g4 193 8 5 5 LS cord-354029-mp5r82g4 193 9 ) ) -RRB- cord-354029-mp5r82g4 193 10 lead lead VB cord-354029-mp5r82g4 193 11 to to IN cord-354029-mp5r82g4 193 12 the the DT cord-354029-mp5r82g4 193 13 formation formation NN cord-354029-mp5r82g4 193 14 of of IN cord-354029-mp5r82g4 193 15 a a DT cord-354029-mp5r82g4 193 16 six six CD cord-354029-mp5r82g4 193 17 - - HYPH cord-354029-mp5r82g4 193 18 helix helix NN cord-354029-mp5r82g4 193 19 bundle bundle NN cord-354029-mp5r82g4 193 20 , , , cord-354029-mp5r82g4 193 21 resulting result VBG cord-354029-mp5r82g4 193 22 in in IN cord-354029-mp5r82g4 193 23 hemifusion hemifusion NN cord-354029-mp5r82g4 193 24 ( ( -LRB- cord-354029-mp5r82g4 193 25 Step step NN cord-354029-mp5r82g4 193 26 5 5 CD cord-354029-mp5r82g4 193 27 ) ) -RRB- cord-354029-mp5r82g4 193 28 ( ( -LRB- cord-354029-mp5r82g4 193 29 defined define VBN cord-354029-mp5r82g4 193 30 as as IN cord-354029-mp5r82g4 193 31 mixing mix VBG cord-354029-mp5r82g4 193 32 of of IN cord-354029-mp5r82g4 193 33 the the DT cord-354029-mp5r82g4 193 34 outer outer JJ cord-354029-mp5r82g4 193 35 leaflets leaflet NNS cord-354029-mp5r82g4 193 36 of of IN cord-354029-mp5r82g4 193 37 the the DT cord-354029-mp5r82g4 193 38 viral viral JJ cord-354029-mp5r82g4 193 39 and and CC cord-354029-mp5r82g4 193 40 cellular cellular JJ cord-354029-mp5r82g4 193 41 membranes membrane NNS cord-354029-mp5r82g4 193 42 ) ) -RRB- cord-354029-mp5r82g4 193 43 . . . cord-354029-mp5r82g4 194 1 Eventually eventually RB cord-354029-mp5r82g4 194 2 a a DT cord-354029-mp5r82g4 194 3 fusion fusion NN cord-354029-mp5r82g4 194 4 pore pore NN cord-354029-mp5r82g4 194 5 forms form NNS cord-354029-mp5r82g4 194 6 ( ( -LRB- cord-354029-mp5r82g4 194 7 Step Step NNP cord-354029-mp5r82g4 194 8 6 6 CD cord-354029-mp5r82g4 194 9 ) ) -RRB- cord-354029-mp5r82g4 194 10 and and CC cord-354029-mp5r82g4 194 11 enlarges enlarge VBZ cord-354029-mp5r82g4 194 12 ( ( -LRB- cord-354029-mp5r82g4 194 13 not not RB cord-354029-mp5r82g4 194 14 shown show VBN cord-354029-mp5r82g4 194 15 ) ) -RRB- cord-354029-mp5r82g4 194 16 formational formational JJ cord-354029-mp5r82g4 194 17 changes change NNS cord-354029-mp5r82g4 194 18 in in IN cord-354029-mp5r82g4 194 19 gp120 gp120 NNP cord-354029-mp5r82g4 194 20 and and CC cord-354029-mp5r82g4 194 21 gp41 gp41 NN cord-354029-mp5r82g4 195 1 ( ( -LRB- cord-354029-mp5r82g4 195 2 Eckert Eckert NNP cord-354029-mp5r82g4 195 3 and and CC cord-354029-mp5r82g4 195 4 Kim Kim NNP cord-354029-mp5r82g4 195 5 2001 2001 CD cord-354029-mp5r82g4 195 6 ; ; : cord-354029-mp5r82g4 195 7 Xiang Xiang NNP cord-354029-mp5r82g4 195 8 et et NNP cord-354029-mp5r82g4 195 9 al al NNP cord-354029-mp5r82g4 195 10 . . . cord-354029-mp5r82g4 195 11 2002 2002 CD cord-354029-mp5r82g4 195 12 ) ) -RRB- cord-354029-mp5r82g4 195 13 . . . cord-354029-mp5r82g4 196 1 A a DT cord-354029-mp5r82g4 196 2 remaining remaining JJ cord-354029-mp5r82g4 196 3 issue issue NN cord-354029-mp5r82g4 196 4 for for IN cord-354029-mp5r82g4 196 5 all all DT cord-354029-mp5r82g4 196 6 receptor receptor NN cord-354029-mp5r82g4 196 7 - - HYPH cord-354029-mp5r82g4 196 8 activated activate VBN cord-354029-mp5r82g4 196 9 viral viral JJ cord-354029-mp5r82g4 196 10 fusion fusion NN cord-354029-mp5r82g4 196 11 proteins protein NNS cord-354029-mp5r82g4 196 12 is be VBZ cord-354029-mp5r82g4 196 13 how how WRB cord-354029-mp5r82g4 196 14 information information NN cord-354029-mp5r82g4 196 15 is be VBZ cord-354029-mp5r82g4 196 16 transmitted transmit VBN cord-354029-mp5r82g4 196 17 ( ( -LRB- cord-354029-mp5r82g4 196 18 after after IN cord-354029-mp5r82g4 196 19 receptor receptor NN cord-354029-mp5r82g4 196 20 binding binding NN cord-354029-mp5r82g4 196 21 ) ) -RRB- cord-354029-mp5r82g4 196 22 through through IN cord-354029-mp5r82g4 196 23 the the DT cord-354029-mp5r82g4 196 24 receptor receptor NN cord-354029-mp5r82g4 196 25 binding bind VBG cord-354029-mp5r82g4 196 26 subunit subunit NN cord-354029-mp5r82g4 196 27 to to IN cord-354029-mp5r82g4 196 28 the the DT cord-354029-mp5r82g4 196 29 fusion fusion NN cord-354029-mp5r82g4 196 30 subunit subunit NN cord-354029-mp5r82g4 196 31 . . . cord-354029-mp5r82g4 197 1 Such such JJ cord-354029-mp5r82g4 197 2 transmission transmission NN cord-354029-mp5r82g4 197 3 is be VBZ cord-354029-mp5r82g4 197 4 essential essential JJ cord-354029-mp5r82g4 197 5 to to TO cord-354029-mp5r82g4 197 6 allow allow VB cord-354029-mp5r82g4 197 7 rearrangements rearrangement NNS cord-354029-mp5r82g4 197 8 in in IN cord-354029-mp5r82g4 197 9 the the DT cord-354029-mp5r82g4 197 10 fusion fusion NN cord-354029-mp5r82g4 197 11 subunit subunit NN cord-354029-mp5r82g4 197 12 ( ( -LRB- cord-354029-mp5r82g4 197 13 e.g. e.g. RB cord-354029-mp5r82g4 197 14 , , , cord-354029-mp5r82g4 197 15 six six CD cord-354029-mp5r82g4 197 16 - - HYPH cord-354029-mp5r82g4 197 17 helix helix NN cord-354029-mp5r82g4 197 18 bundle bundle NN cord-354029-mp5r82g4 197 19 formation formation NN cord-354029-mp5r82g4 197 20 ) ) -RRB- cord-354029-mp5r82g4 197 21 that that WDT cord-354029-mp5r82g4 197 22 drive drive VBP cord-354029-mp5r82g4 197 23 fusion fusion NN cord-354029-mp5r82g4 197 24 . . . cord-354029-mp5r82g4 198 1 For for IN cord-354029-mp5r82g4 198 2 HIV HIV NNP cord-354029-mp5r82g4 198 3 , , , cord-354029-mp5r82g4 198 4 part part NN cord-354029-mp5r82g4 198 5 of of IN cord-354029-mp5r82g4 198 6 the the DT cord-354029-mp5r82g4 198 7 mechanism mechanism NN cord-354029-mp5r82g4 198 8 may may MD cord-354029-mp5r82g4 198 9 involve involve VB cord-354029-mp5r82g4 198 10 reduction reduction NN cord-354029-mp5r82g4 198 11 of of IN cord-354029-mp5r82g4 198 12 one one CD cord-354029-mp5r82g4 198 13 or or CC cord-354029-mp5r82g4 198 14 more more JJR cord-354029-mp5r82g4 198 15 disulfide disulfide JJ cord-354029-mp5r82g4 198 16 bonds bond NNS cord-354029-mp5r82g4 198 17 in in IN cord-354029-mp5r82g4 198 18 gp120 gp120 NNP cord-354029-mp5r82g4 199 1 ( ( -LRB- cord-354029-mp5r82g4 199 2 Abrahamyan Abrahamyan NNP cord-354029-mp5r82g4 199 3 et et NNP cord-354029-mp5r82g4 199 4 al al NNP cord-354029-mp5r82g4 199 5 . . . cord-354029-mp5r82g4 200 1 2003 2003 CD cord-354029-mp5r82g4 200 2 ; ; : cord-354029-mp5r82g4 200 3 Barbouche Barbouche NNP cord-354029-mp5r82g4 200 4 et et NNP cord-354029-mp5r82g4 200 5 al al NNP cord-354029-mp5r82g4 200 6 . . . cord-354029-mp5r82g4 201 1 2003 2003 CD cord-354029-mp5r82g4 201 2 ; ; : cord-354029-mp5r82g4 201 3 Fenouillet Fenouillet NNP cord-354029-mp5r82g4 201 4 et et NNP cord-354029-mp5r82g4 201 5 al al NNP cord-354029-mp5r82g4 201 6 . . . cord-354029-mp5r82g4 202 1 2001 2001 CD cord-354029-mp5r82g4 202 2 ; ; : cord-354029-mp5r82g4 202 3 Gallina Gallina NNP cord-354029-mp5r82g4 202 4 et et FW cord-354029-mp5r82g4 202 5 al al NNP cord-354029-mp5r82g4 202 6 . . . cord-354029-mp5r82g4 202 7 2002 2002 CD cord-354029-mp5r82g4 202 8 ) ) -RRB- cord-354029-mp5r82g4 202 9 . . . cord-354029-mp5r82g4 203 1 In in IN cord-354029-mp5r82g4 203 2 murine murine JJ cord-354029-mp5r82g4 203 3 retroviral retroviral NN cord-354029-mp5r82g4 203 4 Envs Envs NNP cord-354029-mp5r82g4 203 5 , , , cord-354029-mp5r82g4 203 6 a a DT cord-354029-mp5r82g4 203 7 proline proline JJ cord-354029-mp5r82g4 203 8 - - HYPH cord-354029-mp5r82g4 203 9 rich rich JJ cord-354029-mp5r82g4 203 10 hinge hinge NN cord-354029-mp5r82g4 203 11 region region NN cord-354029-mp5r82g4 203 12 appears appear VBZ cord-354029-mp5r82g4 203 13 to to TO cord-354029-mp5r82g4 203 14 relay relay VB cord-354029-mp5r82g4 203 15 receptor receptor NN cord-354029-mp5r82g4 203 16 binding bind VBG cord-354029-mp5r82g4 203 17 information information NN cord-354029-mp5r82g4 203 18 from from IN cord-354029-mp5r82g4 203 19 the the DT cord-354029-mp5r82g4 203 20 N n CD cord-354029-mp5r82g4 203 21 - - HYPH cord-354029-mp5r82g4 203 22 terminal terminal NN cord-354029-mp5r82g4 203 23 to to IN cord-354029-mp5r82g4 203 24 the the DT cord-354029-mp5r82g4 203 25 C C NNP cord-354029-mp5r82g4 203 26 - - HYPH cord-354029-mp5r82g4 203 27 terminal terminal NN cord-354029-mp5r82g4 203 28 region region NN cord-354029-mp5r82g4 203 29 of of IN cord-354029-mp5r82g4 203 30 the the DT cord-354029-mp5r82g4 203 31 receptor receptor NN cord-354029-mp5r82g4 203 32 binding bind VBG cord-354029-mp5r82g4 203 33 subunits subunit NNS cord-354029-mp5r82g4 203 34 ( ( -LRB- cord-354029-mp5r82g4 203 35 SU SU NNP cord-354029-mp5r82g4 203 36 ) ) -RRB- cord-354029-mp5r82g4 204 1 ( ( -LRB- cord-354029-mp5r82g4 204 2 Barnett Barnett NNP cord-354029-mp5r82g4 204 3 and and CC cord-354029-mp5r82g4 204 4 Cunningham Cunningham NNP cord-354029-mp5r82g4 204 5 2001 2001 CD cord-354029-mp5r82g4 204 6 ; ; : cord-354029-mp5r82g4 204 7 Lavillette Lavillette NNP cord-354029-mp5r82g4 204 8 et et NNP cord-354029-mp5r82g4 204 9 al al NNP cord-354029-mp5r82g4 204 10 . . NNP cord-354029-mp5r82g4 204 11 2001 2001 CD cord-354029-mp5r82g4 204 12 ) ) -RRB- cord-354029-mp5r82g4 204 13 . . . cord-354029-mp5r82g4 205 1 Because because IN cord-354029-mp5r82g4 205 2 the the DT cord-354029-mp5r82g4 205 3 proline proline JJ cord-354029-mp5r82g4 205 4 - - HYPH cord-354029-mp5r82g4 205 5 rich rich JJ cord-354029-mp5r82g4 205 6 region region NN cord-354029-mp5r82g4 205 7 of of IN cord-354029-mp5r82g4 205 8 SU SU NNP cord-354029-mp5r82g4 205 9 is be VBZ cord-354029-mp5r82g4 205 10 linked link VBN cord-354029-mp5r82g4 205 11 to to IN cord-354029-mp5r82g4 205 12 TM TM NNP cord-354029-mp5r82g4 205 13 by by IN cord-354029-mp5r82g4 205 14 a a DT cord-354029-mp5r82g4 205 15 disulfide disulfide JJ cord-354029-mp5r82g4 205 16 bond bond NN cord-354029-mp5r82g4 205 17 ( ( -LRB- cord-354029-mp5r82g4 205 18 Pinter Pinter NNP cord-354029-mp5r82g4 205 19 et et NNP cord-354029-mp5r82g4 205 20 al al NNP cord-354029-mp5r82g4 205 21 . . . cord-354029-mp5r82g4 205 22 1997 1997 CD cord-354029-mp5r82g4 205 23 ) ) -RRB- cord-354029-mp5r82g4 205 24 , , , cord-354029-mp5r82g4 205 25 this this DT cord-354029-mp5r82g4 205 26 may may MD cord-354029-mp5r82g4 205 27 provide provide VB cord-354029-mp5r82g4 205 28 a a DT cord-354029-mp5r82g4 205 29 relay relay NN cord-354029-mp5r82g4 205 30 system system NN cord-354029-mp5r82g4 205 31 to to TO cord-354029-mp5r82g4 205 32 trigger trigger VB cord-354029-mp5r82g4 205 33 conformational conformational JJ cord-354029-mp5r82g4 205 34 changes change NNS cord-354029-mp5r82g4 205 35 in in IN cord-354029-mp5r82g4 205 36 the the DT cord-354029-mp5r82g4 205 37 fusion fusion NN cord-354029-mp5r82g4 205 38 subunit subunit NN cord-354029-mp5r82g4 205 39 . . . cord-354029-mp5r82g4 206 1 Clearly clearly RB cord-354029-mp5r82g4 206 2 , , , cord-354029-mp5r82g4 206 3 the the DT cord-354029-mp5r82g4 206 4 molecular molecular JJ cord-354029-mp5r82g4 206 5 pathways pathway NNS cord-354029-mp5r82g4 206 6 by by IN cord-354029-mp5r82g4 206 7 which which WDT cord-354029-mp5r82g4 206 8 receptor receptor NN cord-354029-mp5r82g4 206 9 - - HYPH cord-354029-mp5r82g4 206 10 activated activate VBN cord-354029-mp5r82g4 206 11 fusion fusion NN cord-354029-mp5r82g4 206 12 proteins protein NNS cord-354029-mp5r82g4 206 13 change change VBP cord-354029-mp5r82g4 206 14 from from IN cord-354029-mp5r82g4 206 15 their -PRON- PRP$ cord-354029-mp5r82g4 206 16 metastable metastable JJ cord-354029-mp5r82g4 206 17 to to IN cord-354029-mp5r82g4 206 18 their -PRON- PRP$ cord-354029-mp5r82g4 206 19 activated activate VBN cord-354029-mp5r82g4 206 20 forms form NNS cord-354029-mp5r82g4 206 21 need need VBP cord-354029-mp5r82g4 206 22 to to TO cord-354029-mp5r82g4 206 23 be be VB cord-354029-mp5r82g4 206 24 defined define VBN cord-354029-mp5r82g4 206 25 . . . cord-354029-mp5r82g4 207 1 In in IN cord-354029-mp5r82g4 207 2 Fig Fig NNP cord-354029-mp5r82g4 207 3 . . . cord-354029-mp5r82g4 208 1 3 3 LS cord-354029-mp5r82g4 208 2 , , , cord-354029-mp5r82g4 208 3 we -PRON- PRP cord-354029-mp5r82g4 208 4 show show VBP cord-354029-mp5r82g4 208 5 a a DT cord-354029-mp5r82g4 208 6 working working NN cord-354029-mp5r82g4 208 7 model model NN cord-354029-mp5r82g4 208 8 for for IN cord-354029-mp5r82g4 208 9 HIV HIV NNP cord-354029-mp5r82g4 208 10 Env Env NNP cord-354029-mp5r82g4 208 11 - - HYPH cord-354029-mp5r82g4 208 12 mediated mediate VBN cord-354029-mp5r82g4 208 13 fusion fusion NN cord-354029-mp5r82g4 208 14 . . . cord-354029-mp5r82g4 209 1 It -PRON- PRP cord-354029-mp5r82g4 209 2 is be VBZ cord-354029-mp5r82g4 209 3 derived derive VBN cord-354029-mp5r82g4 209 4 in in IN cord-354029-mp5r82g4 209 5 part part NN cord-354029-mp5r82g4 209 6 from from IN cord-354029-mp5r82g4 209 7 studies study NNS cord-354029-mp5r82g4 209 8 with with IN cord-354029-mp5r82g4 209 9 influenza influenza NN cord-354029-mp5r82g4 209 10 HA HA NNP cord-354029-mp5r82g4 209 11 , , , cord-354029-mp5r82g4 209 12 and and CC cord-354029-mp5r82g4 209 13 it -PRON- PRP cord-354029-mp5r82g4 209 14 is be VBZ cord-354029-mp5r82g4 209 15 similar similar JJ cord-354029-mp5r82g4 209 16 to to IN cord-354029-mp5r82g4 209 17 other other JJ cord-354029-mp5r82g4 209 18 HIV HIV NNP cord-354029-mp5r82g4 209 19 fusion fusion NN cord-354029-mp5r82g4 209 20 models model NNS cord-354029-mp5r82g4 209 21 ( ( -LRB- cord-354029-mp5r82g4 209 22 Eckert Eckert NNP cord-354029-mp5r82g4 209 23 and and CC cord-354029-mp5r82g4 209 24 Kim Kim NNP cord-354029-mp5r82g4 209 25 2001 2001 CD cord-354029-mp5r82g4 209 26 ) ) -RRB- cord-354029-mp5r82g4 209 27 . . . cord-354029-mp5r82g4 210 1 Our -PRON- PRP$ cord-354029-mp5r82g4 210 2 hypothesis hypothesis NN cord-354029-mp5r82g4 210 3 is be VBZ cord-354029-mp5r82g4 210 4 that that IN cord-354029-mp5r82g4 210 5 all all DT cord-354029-mp5r82g4 210 6 class class NN cord-354029-mp5r82g4 210 7 I -PRON- PRP cord-354029-mp5r82g4 210 8 fusion fusion NN cord-354029-mp5r82g4 210 9 proteins protein NNS cord-354029-mp5r82g4 210 10 will will MD cord-354029-mp5r82g4 210 11 employ employ VB cord-354029-mp5r82g4 210 12 similar similar JJ cord-354029-mp5r82g4 210 13 mechanisms mechanism NNS cord-354029-mp5r82g4 210 14 . . . cord-354029-mp5r82g4 211 1 We -PRON- PRP cord-354029-mp5r82g4 211 2 note note VBP cord-354029-mp5r82g4 211 3 , , , cord-354029-mp5r82g4 211 4 however however RB cord-354029-mp5r82g4 211 5 , , , cord-354029-mp5r82g4 211 6 that that IN cord-354029-mp5r82g4 211 7 even even RB cord-354029-mp5r82g4 211 8 in in IN cord-354029-mp5r82g4 211 9 the the DT cord-354029-mp5r82g4 211 10 case case NN cord-354029-mp5r82g4 211 11 of of IN cord-354029-mp5r82g4 211 12 influenza influenza NN cord-354029-mp5r82g4 211 13 HA HA NNP cord-354029-mp5r82g4 211 14 , , , cord-354029-mp5r82g4 211 15 alternate alternate JJ cord-354029-mp5r82g4 211 16 models model NNS cord-354029-mp5r82g4 211 17 are be VBP cord-354029-mp5r82g4 211 18 still still RB cord-354029-mp5r82g4 211 19 entertained entertain VBN cord-354029-mp5r82g4 211 20 ( ( -LRB- cord-354029-mp5r82g4 211 21 see see VB cord-354029-mp5r82g4 211 22 Fig Fig NNP cord-354029-mp5r82g4 211 23 . . NNP cord-354029-mp5r82g4 211 24 2 2 CD cord-354029-mp5r82g4 211 25 in in IN cord-354029-mp5r82g4 211 26 Jahn Jahn NNP cord-354029-mp5r82g4 211 27 et et NNP cord-354029-mp5r82g4 211 28 al al NNP cord-354029-mp5r82g4 211 29 . . NNP cord-354029-mp5r82g4 211 30 2003 2003 CD cord-354029-mp5r82g4 211 31 ) ) -RRB- cord-354029-mp5r82g4 211 32 . . . cord-354029-mp5r82g4 212 1 Furthermore furthermore RB cord-354029-mp5r82g4 212 2 , , , cord-354029-mp5r82g4 212 3 others other NNS cord-354029-mp5r82g4 212 4 have have VBP cord-354029-mp5r82g4 212 5 suggested suggest VBN cord-354029-mp5r82g4 212 6 that that IN cord-354029-mp5r82g4 212 7 different different JJ cord-354029-mp5r82g4 212 8 class class NN cord-354029-mp5r82g4 212 9 I -PRON- PRP cord-354029-mp5r82g4 212 10 fusion fusion NN cord-354029-mp5r82g4 212 11 proteins protein NNS cord-354029-mp5r82g4 212 12 may may MD cord-354029-mp5r82g4 212 13 use use VB cord-354029-mp5r82g4 212 14 fundamentally fundamentally RB cord-354029-mp5r82g4 212 15 different different JJ cord-354029-mp5r82g4 212 16 mechanisms mechanism NNS cord-354029-mp5r82g4 213 1 ( ( -LRB- cord-354029-mp5r82g4 213 2 Chen Chen NNP cord-354029-mp5r82g4 213 3 et et NNP cord-354029-mp5r82g4 213 4 al al NNP cord-354029-mp5r82g4 213 5 . . NNP cord-354029-mp5r82g4 213 6 2001a 2001a CD cord-354029-mp5r82g4 213 7 ) ) -RRB- cord-354029-mp5r82g4 213 8 . . . cord-354029-mp5r82g4 214 1 The the DT cord-354029-mp5r82g4 214 2 features feature NNS cord-354029-mp5r82g4 214 3 that that WDT cord-354029-mp5r82g4 214 4 we -PRON- PRP cord-354029-mp5r82g4 214 5 predict predict VBP cord-354029-mp5r82g4 214 6 will will MD cord-354029-mp5r82g4 214 7 be be VB cord-354029-mp5r82g4 214 8 common common JJ cord-354029-mp5r82g4 214 9 to to IN cord-354029-mp5r82g4 214 10 the the DT cord-354029-mp5r82g4 214 11 fusion fusion NN cord-354029-mp5r82g4 214 12 mechanisms mechanism NNS cord-354029-mp5r82g4 214 13 of of IN cord-354029-mp5r82g4 214 14 all all DT cord-354029-mp5r82g4 214 15 class class NN cord-354029-mp5r82g4 215 1 I -PRON- PRP cord-354029-mp5r82g4 215 2 fusion fusion NN cord-354029-mp5r82g4 215 3 proteins protein NNS cord-354029-mp5r82g4 216 1 ( ( -LRB- cord-354029-mp5r82g4 216 2 Fig Fig NNP cord-354029-mp5r82g4 216 3 . . . cord-354029-mp5r82g4 216 4 3 3 LS cord-354029-mp5r82g4 216 5 ) ) -RRB- cord-354029-mp5r82g4 216 6 include include VBP cord-354029-mp5r82g4 216 7 : : : cord-354029-mp5r82g4 216 8 ( ( -LRB- cord-354029-mp5r82g4 216 9 1 1 LS cord-354029-mp5r82g4 216 10 ) ) -RRB- cord-354029-mp5r82g4 216 11 conversion conversion NN cord-354029-mp5r82g4 216 12 from from IN cord-354029-mp5r82g4 216 13 a a DT cord-354029-mp5r82g4 216 14 metastable metastable JJ cord-354029-mp5r82g4 216 15 state state NN cord-354029-mp5r82g4 216 16 to to IN cord-354029-mp5r82g4 216 17 an an DT cord-354029-mp5r82g4 216 18 activated activate VBN cord-354029-mp5r82g4 216 19 state state NN cord-354029-mp5r82g4 216 20 , , , cord-354029-mp5r82g4 216 21 ( ( -LRB- cord-354029-mp5r82g4 216 22 2 2 LS cord-354029-mp5r82g4 216 23 ) ) -RRB- cord-354029-mp5r82g4 216 24 exposure exposure NN cord-354029-mp5r82g4 216 25 and and CC cord-354029-mp5r82g4 216 26 repositioning repositioning NN cord-354029-mp5r82g4 216 27 of of IN cord-354029-mp5r82g4 216 28 the the DT cord-354029-mp5r82g4 216 29 fusion fusion NN cord-354029-mp5r82g4 216 30 peptide peptide NN cord-354029-mp5r82g4 216 31 for for IN cord-354029-mp5r82g4 216 32 binding bind VBG cord-354029-mp5r82g4 216 33 to to IN cord-354029-mp5r82g4 216 34 the the DT cord-354029-mp5r82g4 216 35 target target NN cord-354029-mp5r82g4 216 36 bilayer bilayer NN cord-354029-mp5r82g4 216 37 , , , cord-354029-mp5r82g4 216 38 ( ( -LRB- cord-354029-mp5r82g4 216 39 3 3 LS cord-354029-mp5r82g4 216 40 ) ) -RRB- cord-354029-mp5r82g4 216 41 recruitment recruitment NN cord-354029-mp5r82g4 216 42 of of IN cord-354029-mp5r82g4 216 43 several several JJ cord-354029-mp5r82g4 216 44 activated activate VBN cord-354029-mp5r82g4 216 45 fusion fusion NN cord-354029-mp5r82g4 216 46 proteins protein NNS cord-354029-mp5r82g4 216 47 to to IN cord-354029-mp5r82g4 216 48 a a DT cord-354029-mp5r82g4 216 49 fusion fusion NN cord-354029-mp5r82g4 216 50 site site NN cord-354029-mp5r82g4 216 51 ( ( -LRB- cord-354029-mp5r82g4 216 52 Blumenthal Blumenthal NNP cord-354029-mp5r82g4 216 53 et et NNP cord-354029-mp5r82g4 216 54 al al NNP cord-354029-mp5r82g4 216 55 . . . cord-354029-mp5r82g4 216 56 1996 1996 CD cord-354029-mp5r82g4 216 57 ; ; : cord-354029-mp5r82g4 216 58 Danieli Danieli NNP cord-354029-mp5r82g4 216 59 et et NNP cord-354029-mp5r82g4 216 60 al al NNP cord-354029-mp5r82g4 216 61 . . . cord-354029-mp5r82g4 217 1 1996 1996 CD cord-354029-mp5r82g4 217 2 ; ; : cord-354029-mp5r82g4 217 3 Markovic Markovic NNP cord-354029-mp5r82g4 217 4 et et NNP cord-354029-mp5r82g4 217 5 al al NNP cord-354029-mp5r82g4 217 6 . . . cord-354029-mp5r82g4 217 7 2001 2001 CD cord-354029-mp5r82g4 218 1 ; ; : cord-354029-mp5r82g4 218 2 Markovic Markovic NNP cord-354029-mp5r82g4 218 3 et et NNP cord-354029-mp5r82g4 218 4 al al NNP cord-354029-mp5r82g4 218 5 . . NNP cord-354029-mp5r82g4 218 6 1998 1998 CD cord-354029-mp5r82g4 218 7 ) ) -RRB- cord-354029-mp5r82g4 218 8 , , , cord-354029-mp5r82g4 218 9 and and CC cord-354029-mp5r82g4 219 1 ( ( -LRB- cord-354029-mp5r82g4 219 2 4 4 LS cord-354029-mp5r82g4 219 3 ) ) -RRB- cord-354029-mp5r82g4 219 4 subsequent subsequent JJ cord-354029-mp5r82g4 219 5 conformational conformational JJ cord-354029-mp5r82g4 219 6 changes change NNS cord-354029-mp5r82g4 219 7 that that WDT cord-354029-mp5r82g4 219 8 result result VBP cord-354029-mp5r82g4 219 9 in in IN cord-354029-mp5r82g4 219 10 close close JJ cord-354029-mp5r82g4 219 11 apposition apposition NN cord-354029-mp5r82g4 219 12 of of IN cord-354029-mp5r82g4 219 13 the the DT cord-354029-mp5r82g4 219 14 fusion fusion NN cord-354029-mp5r82g4 219 15 peptide peptide NN cord-354029-mp5r82g4 219 16 and and CC cord-354029-mp5r82g4 219 17 the the DT cord-354029-mp5r82g4 219 18 transmembrane transmembrane NN cord-354029-mp5r82g4 219 19 domain domain NN cord-354029-mp5r82g4 219 20 . . . cord-354029-mp5r82g4 220 1 The the DT cord-354029-mp5r82g4 220 2 viral viral JJ cord-354029-mp5r82g4 220 3 fusion fusion NN cord-354029-mp5r82g4 220 4 proteins protein NNS cord-354029-mp5r82g4 220 5 that that WDT cord-354029-mp5r82g4 220 6 have have VBP cord-354029-mp5r82g4 220 7 thus thus RB cord-354029-mp5r82g4 220 8 far far RB cord-354029-mp5r82g4 220 9 been be VBN cord-354029-mp5r82g4 220 10 discussed discuss VBN cord-354029-mp5r82g4 220 11 in in IN cord-354029-mp5r82g4 220 12 detail detail NN cord-354029-mp5r82g4 220 13 contain contain VBP cord-354029-mp5r82g4 220 14 a a DT cord-354029-mp5r82g4 220 15 receptor receptor NN cord-354029-mp5r82g4 220 16 binding bind VBG cord-354029-mp5r82g4 220 17 domain domain NN cord-354029-mp5r82g4 220 18 ( ( -LRB- cord-354029-mp5r82g4 220 19 e.g. e.g. RB cord-354029-mp5r82g4 220 20 , , , cord-354029-mp5r82g4 220 21 the the DT cord-354029-mp5r82g4 220 22 gp120 gp120 NNP cord-354029-mp5r82g4 220 23 subunit subunit NN cord-354029-mp5r82g4 220 24 of of IN cord-354029-mp5r82g4 220 25 HIV HIV NNP cord-354029-mp5r82g4 220 26 Env Env NNP cord-354029-mp5r82g4 220 27 ) ) -RRB- cord-354029-mp5r82g4 220 28 within within IN cord-354029-mp5r82g4 220 29 the the DT cord-354029-mp5r82g4 220 30 fusion fusion NN cord-354029-mp5r82g4 220 31 protein protein NN cord-354029-mp5r82g4 220 32 spike spike NN cord-354029-mp5r82g4 220 33 . . . cord-354029-mp5r82g4 221 1 In in IN cord-354029-mp5r82g4 221 2 other other JJ cord-354029-mp5r82g4 221 3 cases case NNS cord-354029-mp5r82g4 221 4 , , , cord-354029-mp5r82g4 221 5 the the DT cord-354029-mp5r82g4 221 6 receptor receptor NN cord-354029-mp5r82g4 221 7 binding bind VBG cord-354029-mp5r82g4 221 8 do do VB cord-354029-mp5r82g4 221 9 - - HYPH cord-354029-mp5r82g4 221 10 main main NN cord-354029-mp5r82g4 221 11 resides reside NNS cord-354029-mp5r82g4 221 12 in in IN cord-354029-mp5r82g4 221 13 a a DT cord-354029-mp5r82g4 221 14 separate separate JJ cord-354029-mp5r82g4 221 15 viral viral JJ cord-354029-mp5r82g4 221 16 spike spike NN cord-354029-mp5r82g4 221 17 . . . cord-354029-mp5r82g4 222 1 Paramyxoviruses paramyxovirus NNS cord-354029-mp5r82g4 222 2 have have VBP cord-354029-mp5r82g4 222 3 an an DT cord-354029-mp5r82g4 222 4 attachment attachment NN cord-354029-mp5r82g4 222 5 protein protein NN cord-354029-mp5r82g4 222 6 spike spike NN cord-354029-mp5r82g4 222 7 and and CC cord-354029-mp5r82g4 222 8 a a DT cord-354029-mp5r82g4 222 9 separate separate JJ cord-354029-mp5r82g4 222 10 fusion fusion NN cord-354029-mp5r82g4 222 11 ( ( -LRB- cord-354029-mp5r82g4 222 12 F F NNP cord-354029-mp5r82g4 222 13 ) ) -RRB- cord-354029-mp5r82g4 222 14 protein protein NN cord-354029-mp5r82g4 222 15 spike spike NN cord-354029-mp5r82g4 222 16 . . . cord-354029-mp5r82g4 223 1 Most Most JJS cord-354029-mp5r82g4 223 2 , , , cord-354029-mp5r82g4 223 3 but but CC cord-354029-mp5r82g4 223 4 not not RB cord-354029-mp5r82g4 223 5 all all DT cord-354029-mp5r82g4 223 6 , , , cord-354029-mp5r82g4 223 7 paramyxoviruses paramyxovirus NNS cord-354029-mp5r82g4 223 8 require require VBP cord-354029-mp5r82g4 223 9 both both CC cord-354029-mp5r82g4 223 10 the the DT cord-354029-mp5r82g4 223 11 attachment attachment NN cord-354029-mp5r82g4 223 12 protein protein NN cord-354029-mp5r82g4 223 13 and and CC cord-354029-mp5r82g4 223 14 the the DT cord-354029-mp5r82g4 223 15 F F NNP cord-354029-mp5r82g4 223 16 protein protein NN cord-354029-mp5r82g4 223 17 for for IN cord-354029-mp5r82g4 223 18 fusion fusion NN cord-354029-mp5r82g4 223 19 ( ( -LRB- cord-354029-mp5r82g4 223 20 Bagai Bagai NNP cord-354029-mp5r82g4 223 21 and and CC cord-354029-mp5r82g4 223 22 Lamb Lamb NNP cord-354029-mp5r82g4 223 23 1995 1995 CD cord-354029-mp5r82g4 223 24 ; ; : cord-354029-mp5r82g4 223 25 Paterson Paterson NNP cord-354029-mp5r82g4 223 26 et et NNP cord-354029-mp5r82g4 223 27 al al NNP cord-354029-mp5r82g4 223 28 . . . cord-354029-mp5r82g4 223 29 2000 2000 CD cord-354029-mp5r82g4 223 30 ) ) -RRB- cord-354029-mp5r82g4 223 31 . . . cord-354029-mp5r82g4 224 1 In in IN cord-354029-mp5r82g4 224 2 most most JJS cord-354029-mp5r82g4 224 3 cases case NNS cord-354029-mp5r82g4 224 4 , , , cord-354029-mp5r82g4 224 5 the the DT cord-354029-mp5r82g4 224 6 attachment attachment NN cord-354029-mp5r82g4 224 7 protein protein NN cord-354029-mp5r82g4 224 8 must must MD cord-354029-mp5r82g4 224 9 come come VB cord-354029-mp5r82g4 224 10 from from IN cord-354029-mp5r82g4 224 11 the the DT cord-354029-mp5r82g4 224 12 same same JJ cord-354029-mp5r82g4 224 13 paramyxovirus paramyxovirus NN cord-354029-mp5r82g4 224 14 as as IN cord-354029-mp5r82g4 224 15 the the DT cord-354029-mp5r82g4 224 16 fusion fusion NN cord-354029-mp5r82g4 224 17 protein protein NN cord-354029-mp5r82g4 224 18 ( ( -LRB- cord-354029-mp5r82g4 224 19 Bossart Bossart NNP cord-354029-mp5r82g4 224 20 et et NNP cord-354029-mp5r82g4 224 21 al al NNP cord-354029-mp5r82g4 224 22 . . . cord-354029-mp5r82g4 224 23 2002 2002 CD cord-354029-mp5r82g4 224 24 ) ) -RRB- cord-354029-mp5r82g4 224 25 . . . cord-354029-mp5r82g4 225 1 In in IN cord-354029-mp5r82g4 225 2 the the DT cord-354029-mp5r82g4 225 3 few few JJ cord-354029-mp5r82g4 225 4 cases case NNS cord-354029-mp5r82g4 225 5 in in IN cord-354029-mp5r82g4 225 6 which which WDT cord-354029-mp5r82g4 225 7 the the DT cord-354029-mp5r82g4 225 8 F F NNP cord-354029-mp5r82g4 225 9 protein protein NN cord-354029-mp5r82g4 225 10 is be VBZ cord-354029-mp5r82g4 225 11 sufficient sufficient JJ cord-354029-mp5r82g4 225 12 , , , cord-354029-mp5r82g4 225 13 fusion fusion NN cord-354029-mp5r82g4 225 14 is be VBZ cord-354029-mp5r82g4 225 15 enhanced enhance VBN cord-354029-mp5r82g4 225 16 if if IN cord-354029-mp5r82g4 225 17 the the DT cord-354029-mp5r82g4 225 18 attachment attachment NN cord-354029-mp5r82g4 225 19 protein protein NN cord-354029-mp5r82g4 225 20 is be VBZ cord-354029-mp5r82g4 225 21 also also RB cord-354029-mp5r82g4 225 22 expressed express VBN cord-354029-mp5r82g4 225 23 ( ( -LRB- cord-354029-mp5r82g4 225 24 Bagai Bagai NNP cord-354029-mp5r82g4 225 25 and and CC cord-354029-mp5r82g4 225 26 Lamb Lamb NNP cord-354029-mp5r82g4 225 27 1995 1995 CD cord-354029-mp5r82g4 225 28 ) ) -RRB- cord-354029-mp5r82g4 225 29 . . . cord-354029-mp5r82g4 226 1 The the DT cord-354029-mp5r82g4 226 2 need need NN cord-354029-mp5r82g4 226 3 for for IN cord-354029-mp5r82g4 226 4 the the DT cord-354029-mp5r82g4 226 5 attachment attachment NN cord-354029-mp5r82g4 226 6 protein protein NN cord-354029-mp5r82g4 226 7 can can MD cord-354029-mp5r82g4 226 8 be be VB cord-354029-mp5r82g4 226 9 overcome overcome VBN cord-354029-mp5r82g4 226 10 by by IN cord-354029-mp5r82g4 226 11 mutations mutation NNS cord-354029-mp5r82g4 226 12 in in IN cord-354029-mp5r82g4 226 13 the the DT cord-354029-mp5r82g4 226 14 F F NNP cord-354029-mp5r82g4 226 15 protein protein NN cord-354029-mp5r82g4 226 16 ( ( -LRB- cord-354029-mp5r82g4 226 17 Paterson Paterson NNP cord-354029-mp5r82g4 226 18 et et NNP cord-354029-mp5r82g4 226 19 al al NNP cord-354029-mp5r82g4 226 20 . . . cord-354029-mp5r82g4 226 21 2000 2000 CD cord-354029-mp5r82g4 226 22 ; ; : cord-354029-mp5r82g4 226 23 Seth Seth NNP cord-354029-mp5r82g4 226 24 et et NNP cord-354029-mp5r82g4 226 25 al al NNP cord-354029-mp5r82g4 226 26 . . NNP cord-354029-mp5r82g4 226 27 2003 2003 CD cord-354029-mp5r82g4 226 28 ) ) -RRB- cord-354029-mp5r82g4 226 29 or or CC cord-354029-mp5r82g4 226 30 by by IN cord-354029-mp5r82g4 226 31 conducting conduct VBG cord-354029-mp5r82g4 226 32 fusion fusion NN cord-354029-mp5r82g4 226 33 reactions reaction NNS cord-354029-mp5r82g4 226 34 at at IN cord-354029-mp5r82g4 226 35 T>37C T>37C NNP cord-354029-mp5r82g4 226 36 ( ( -LRB- cord-354029-mp5r82g4 226 37 Paterson Paterson NNP cord-354029-mp5r82g4 226 38 et et NNP cord-354029-mp5r82g4 226 39 al al NNP cord-354029-mp5r82g4 226 40 . . . cord-354029-mp5r82g4 226 41 2000 2000 CD cord-354029-mp5r82g4 226 42 ; ; : cord-354029-mp5r82g4 226 43 Wharton Wharton NNP cord-354029-mp5r82g4 226 44 et et NNP cord-354029-mp5r82g4 226 45 al al NNP cord-354029-mp5r82g4 226 46 . . . cord-354029-mp5r82g4 226 47 2000 2000 CD cord-354029-mp5r82g4 226 48 ) ) -RRB- cord-354029-mp5r82g4 226 49 . . . cord-354029-mp5r82g4 227 1 Paramyxovirus paramyxovirus JJ cord-354029-mp5r82g4 227 2 fusion fusion NN cord-354029-mp5r82g4 227 3 proteins protein NNS cord-354029-mp5r82g4 227 4 thus thus RB cord-354029-mp5r82g4 227 5 represent represent VBP cord-354029-mp5r82g4 227 6 special special JJ cord-354029-mp5r82g4 227 7 cases case NNS cord-354029-mp5r82g4 227 8 of of IN cord-354029-mp5r82g4 227 9 receptor receptor NN cord-354029-mp5r82g4 227 10 - - HYPH cord-354029-mp5r82g4 227 11 activated activate VBN cord-354029-mp5r82g4 227 12 fusion fusion NN cord-354029-mp5r82g4 227 13 proteins protein NNS cord-354029-mp5r82g4 227 14 , , , cord-354029-mp5r82g4 227 15 in in IN cord-354029-mp5r82g4 227 16 which which WDT cord-354029-mp5r82g4 227 17 receptor receptor NN cord-354029-mp5r82g4 227 18 activation activation NN cord-354029-mp5r82g4 227 19 is be VBZ cord-354029-mp5r82g4 227 20 communicated communicate VBN cord-354029-mp5r82g4 227 21 from from IN cord-354029-mp5r82g4 227 22 one one CD cord-354029-mp5r82g4 227 23 viral viral JJ cord-354029-mp5r82g4 227 24 spike spike NN cord-354029-mp5r82g4 227 25 glycoprotein glycoprotein NN cord-354029-mp5r82g4 227 26 to to IN cord-354029-mp5r82g4 227 27 another another DT cord-354029-mp5r82g4 227 28 . . . cord-354029-mp5r82g4 228 1 F F NNP cord-354029-mp5r82g4 228 2 proteins protein NNS cord-354029-mp5r82g4 228 3 are be VBP cord-354029-mp5r82g4 228 4 proteolytically proteolytically RB cord-354029-mp5r82g4 228 5 cleaved cleave VBN cord-354029-mp5r82g4 228 6 during during IN cord-354029-mp5r82g4 228 7 biosynthesis biosynthesis NN cord-354029-mp5r82g4 228 8 to to TO cord-354029-mp5r82g4 228 9 generate generate VB cord-354029-mp5r82g4 228 10 two two CD cord-354029-mp5r82g4 228 11 disulfide disulfide RB cord-354029-mp5r82g4 228 12 - - HYPH cord-354029-mp5r82g4 228 13 bonded bond VBN cord-354029-mp5r82g4 228 14 subunits subunit NNS cord-354029-mp5r82g4 228 15 , , , cord-354029-mp5r82g4 228 16 F F NNP cord-354029-mp5r82g4 228 17 1 1 CD cord-354029-mp5r82g4 228 18 and and CC cord-354029-mp5r82g4 228 19 F F NNP cord-354029-mp5r82g4 228 20 2 2 CD cord-354029-mp5r82g4 229 1 ( ( -LRB- cord-354029-mp5r82g4 229 2 Begona Begona NNP cord-354029-mp5r82g4 229 3 Ruiz Ruiz NNP cord-354029-mp5r82g4 229 4 - - HYPH cord-354029-mp5r82g4 229 5 Arguello Arguello NNP cord-354029-mp5r82g4 229 6 et et NNP cord-354029-mp5r82g4 229 7 al al NNP cord-354029-mp5r82g4 229 8 . . . cord-354029-mp5r82g4 230 1 2002 2002 CD cord-354029-mp5r82g4 230 2 ; ; : cord-354029-mp5r82g4 230 3 Gonzalez Gonzalez NNP cord-354029-mp5r82g4 230 4 - - HYPH cord-354029-mp5r82g4 230 5 Reyes Reyes NNP cord-354029-mp5r82g4 230 6 et et NNP cord-354029-mp5r82g4 230 7 al al NNP cord-354029-mp5r82g4 230 8 . . . cord-354029-mp5r82g4 231 1 2001 2001 CD cord-354029-mp5r82g4 231 2 ; ; : cord-354029-mp5r82g4 231 3 Lamb Lamb NNP cord-354029-mp5r82g4 231 4 1993 1993 CD cord-354029-mp5r82g4 231 5 ) ) -RRB- cord-354029-mp5r82g4 231 6 , , , cord-354029-mp5r82g4 231 7 found find VBD cord-354029-mp5r82g4 231 8 as as IN cord-354029-mp5r82g4 231 9 metastable metastable JJ cord-354029-mp5r82g4 231 10 trimers trimer NNS cord-354029-mp5r82g4 231 11 of of IN cord-354029-mp5r82g4 231 12 dimers dimer NNS cord-354029-mp5r82g4 231 13 ( ( -LRB- cord-354029-mp5r82g4 231 14 Baker Baker NNP cord-354029-mp5r82g4 231 15 et et NNP cord-354029-mp5r82g4 231 16 al al NNP cord-354029-mp5r82g4 231 17 . . . cord-354029-mp5r82g4 231 18 1999 1999 CD cord-354029-mp5r82g4 231 19 ) ) -RRB- cord-354029-mp5r82g4 231 20 on on IN cord-354029-mp5r82g4 231 21 virions virion NNS cord-354029-mp5r82g4 231 22 . . . cord-354029-mp5r82g4 232 1 It -PRON- PRP cord-354029-mp5r82g4 232 2 has have VBZ cord-354029-mp5r82g4 232 3 been be VBN cord-354029-mp5r82g4 232 4 suggested suggest VBN cord-354029-mp5r82g4 232 5 that that IN cord-354029-mp5r82g4 232 6 binding binding NN cord-354029-mp5r82g4 232 7 of of IN cord-354029-mp5r82g4 232 8 the the DT cord-354029-mp5r82g4 232 9 attachment attachment NN cord-354029-mp5r82g4 232 10 protein protein NN cord-354029-mp5r82g4 232 11 to to IN cord-354029-mp5r82g4 232 12 a a DT cord-354029-mp5r82g4 232 13 host host NN cord-354029-mp5r82g4 232 14 cell cell NN cord-354029-mp5r82g4 232 15 receptor receptor NN cord-354029-mp5r82g4 232 16 causes cause VBZ cord-354029-mp5r82g4 232 17 conformational conformational JJ cord-354029-mp5r82g4 232 18 changes change NNS cord-354029-mp5r82g4 232 19 in in IN cord-354029-mp5r82g4 232 20 this this DT cord-354029-mp5r82g4 232 21 protein protein NN cord-354029-mp5r82g4 232 22 , , , cord-354029-mp5r82g4 232 23 which which WDT cord-354029-mp5r82g4 232 24 in in IN cord-354029-mp5r82g4 232 25 turn turn NN cord-354029-mp5r82g4 232 26 cause cause VBP cord-354029-mp5r82g4 232 27 activating activate VBG cord-354029-mp5r82g4 232 28 conformational conformational JJ cord-354029-mp5r82g4 232 29 changes change NNS cord-354029-mp5r82g4 232 30 in in IN cord-354029-mp5r82g4 232 31 the the DT cord-354029-mp5r82g4 232 32 metastable metastable JJ cord-354029-mp5r82g4 232 33 F f NN cord-354029-mp5r82g4 232 34 protein protein NN cord-354029-mp5r82g4 232 35 ( ( -LRB- cord-354029-mp5r82g4 232 36 Lamb Lamb NNP cord-354029-mp5r82g4 232 37 1993 1993 CD cord-354029-mp5r82g4 232 38 ; ; : cord-354029-mp5r82g4 232 39 Russell Russell NNP cord-354029-mp5r82g4 232 40 et et NNP cord-354029-mp5r82g4 232 41 al al NNP cord-354029-mp5r82g4 232 42 . . . cord-354029-mp5r82g4 233 1 2001 2001 CD cord-354029-mp5r82g4 233 2 ; ; : cord-354029-mp5r82g4 233 3 Takimoto Takimoto NNP cord-354029-mp5r82g4 233 4 et et NNP cord-354029-mp5r82g4 233 5 al al NNP cord-354029-mp5r82g4 233 6 . . . cord-354029-mp5r82g4 233 7 2002 2002 CD cord-354029-mp5r82g4 233 8 ) ) -RRB- cord-354029-mp5r82g4 233 9 . . . cord-354029-mp5r82g4 234 1 The the DT cord-354029-mp5r82g4 234 2 exact exact JJ cord-354029-mp5r82g4 234 3 mechanism mechanism NN cord-354029-mp5r82g4 234 4 by by IN cord-354029-mp5r82g4 234 5 which which WDT cord-354029-mp5r82g4 234 6 attachment attachment NN cord-354029-mp5r82g4 234 7 proteins protein NNS cord-354029-mp5r82g4 234 8 activate activate VBP cord-354029-mp5r82g4 234 9 F F NNP cord-354029-mp5r82g4 234 10 proteins protein NNS cord-354029-mp5r82g4 234 11 is be VBZ cord-354029-mp5r82g4 234 12 not not RB cord-354029-mp5r82g4 234 13 known know VBN cord-354029-mp5r82g4 234 14 , , , cord-354029-mp5r82g4 234 15 but but CC cord-354029-mp5r82g4 234 16 several several JJ cord-354029-mp5r82g4 234 17 groups group NNS cord-354029-mp5r82g4 234 18 have have VBP cord-354029-mp5r82g4 234 19 provided provide VBN cord-354029-mp5r82g4 234 20 evidence evidence NN cord-354029-mp5r82g4 234 21 for for IN cord-354029-mp5r82g4 234 22 cross cross NN cord-354029-mp5r82g4 234 23 talk talk NN cord-354029-mp5r82g4 234 24 between between IN cord-354029-mp5r82g4 234 25 attachment attachment NN cord-354029-mp5r82g4 234 26 and and CC cord-354029-mp5r82g4 234 27 F f NN cord-354029-mp5r82g4 234 28 proteins protein NNS cord-354029-mp5r82g4 235 1 ( ( -LRB- cord-354029-mp5r82g4 235 2 Bossart Bossart NNP cord-354029-mp5r82g4 235 3 et et NNP cord-354029-mp5r82g4 235 4 al al NNP cord-354029-mp5r82g4 235 5 . . . cord-354029-mp5r82g4 236 1 2002 2002 CD cord-354029-mp5r82g4 236 2 ; ; : cord-354029-mp5r82g4 236 3 Deng Deng NNP cord-354029-mp5r82g4 236 4 et et NNP cord-354029-mp5r82g4 236 5 al al NNP cord-354029-mp5r82g4 236 6 . . . cord-354029-mp5r82g4 237 1 1999 1999 CD cord-354029-mp5r82g4 237 2 ; ; : cord-354029-mp5r82g4 237 3 McGinnes McGinnes NNP cord-354029-mp5r82g4 237 4 et et NNP cord-354029-mp5r82g4 237 5 al al NNP cord-354029-mp5r82g4 237 6 . . . cord-354029-mp5r82g4 238 1 2002 2002 CD cord-354029-mp5r82g4 238 2 ; ; : cord-354029-mp5r82g4 238 3 Stone Stone NNP cord-354029-mp5r82g4 238 4 - - HYPH cord-354029-mp5r82g4 238 5 Hulslander Hulslander NNP cord-354029-mp5r82g4 238 6 and and CC cord-354029-mp5r82g4 238 7 Morrison Morrison NNP cord-354029-mp5r82g4 238 8 1997 1997 CD cord-354029-mp5r82g4 238 9 ; ; : cord-354029-mp5r82g4 238 10 Takimoto Takimoto NNP cord-354029-mp5r82g4 238 11 et et NNP cord-354029-mp5r82g4 238 12 al al NNP cord-354029-mp5r82g4 238 13 . . . cord-354029-mp5r82g4 238 14 2002 2002 CD cord-354029-mp5r82g4 238 15 ; ; : cord-354029-mp5r82g4 238 16 Yao Yao NNP cord-354029-mp5r82g4 238 17 et et NNP cord-354029-mp5r82g4 238 18 al al NNP cord-354029-mp5r82g4 238 19 . . . cord-354029-mp5r82g4 238 20 1997 1997 CD cord-354029-mp5r82g4 238 21 ) ) -RRB- cord-354029-mp5r82g4 238 22 . . . cord-354029-mp5r82g4 239 1 The the DT cord-354029-mp5r82g4 239 2 post post JJ cord-354029-mp5r82g4 239 3 - - JJ cord-354029-mp5r82g4 239 4 fusion fusion JJ cord-354029-mp5r82g4 239 5 form form NN cord-354029-mp5r82g4 239 6 of of IN cord-354029-mp5r82g4 239 7 the the DT cord-354029-mp5r82g4 239 8 F F NNP cord-354029-mp5r82g4 239 9 protein protein NN cord-354029-mp5r82g4 239 10 from from IN cord-354029-mp5r82g4 239 11 the the DT cord-354029-mp5r82g4 239 12 paramyxovirus paramyxovirus NNP cord-354029-mp5r82g4 239 13 SV5 SV5 NNP cord-354029-mp5r82g4 239 14 contains contain VBZ cord-354029-mp5r82g4 239 15 a a DT cord-354029-mp5r82g4 239 16 six six CD cord-354029-mp5r82g4 239 17 - - HYPH cord-354029-mp5r82g4 239 18 helix helix NN cord-354029-mp5r82g4 239 19 bundle bundle NN cord-354029-mp5r82g4 239 20 ( ( -LRB- cord-354029-mp5r82g4 239 21 Baker Baker NNP cord-354029-mp5r82g4 239 22 et et NNP cord-354029-mp5r82g4 239 23 al al NNP cord-354029-mp5r82g4 239 24 . . . cord-354029-mp5r82g4 239 25 1999 1999 CD cord-354029-mp5r82g4 239 26 ) ) -RRB- cord-354029-mp5r82g4 239 27 . . . cord-354029-mp5r82g4 240 1 Similar similar JJ cord-354029-mp5r82g4 240 2 to to IN cord-354029-mp5r82g4 240 3 HIV HIV NNP cord-354029-mp5r82g4 240 4 Env Env NNP cord-354029-mp5r82g4 240 5 Kilby Kilby NNP cord-354029-mp5r82g4 240 6 et et NNP cord-354029-mp5r82g4 240 7 al al NNP cord-354029-mp5r82g4 240 8 . . . cord-354029-mp5r82g4 241 1 1998 1998 CD cord-354029-mp5r82g4 241 2 ; ; : cord-354029-mp5r82g4 241 3 Munoz Munoz NNP cord-354029-mp5r82g4 241 4 - - HYPH cord-354029-mp5r82g4 241 5 Barroso Barroso NNP cord-354029-mp5r82g4 241 6 et et NNP cord-354029-mp5r82g4 241 7 al al NNP cord-354029-mp5r82g4 241 8 . . NNP cord-354029-mp5r82g4 241 9 1998 1998 CD cord-354029-mp5r82g4 241 10 ) ) -RRB- cord-354029-mp5r82g4 241 11 and and CC cord-354029-mp5r82g4 241 12 other other JJ cord-354029-mp5r82g4 241 13 retroviral retroviral NN cord-354029-mp5r82g4 241 14 fusion fusion NN cord-354029-mp5r82g4 241 15 proteins protein NNS cord-354029-mp5r82g4 242 1 ( ( -LRB- cord-354029-mp5r82g4 242 2 Earp Earp NNP cord-354029-mp5r82g4 242 3 et et NNP cord-354029-mp5r82g4 242 4 al al NNP cord-354029-mp5r82g4 242 5 . . . cord-354029-mp5r82g4 243 1 2003 2003 CD cord-354029-mp5r82g4 243 2 ; ; : cord-354029-mp5r82g4 243 3 Netter Netter NNP cord-354029-mp5r82g4 243 4 2002 2002 CD cord-354029-mp5r82g4 243 5 ) ) -RRB- cord-354029-mp5r82g4 243 6 , , , cord-354029-mp5r82g4 243 7 peptide peptide JJ cord-354029-mp5r82g4 243 8 analogs analog NNS cord-354029-mp5r82g4 243 9 of of IN cord-354029-mp5r82g4 243 10 the the DT cord-354029-mp5r82g4 243 11 N N NNP cord-354029-mp5r82g4 243 12 - - HYPH cord-354029-mp5r82g4 243 13 and and CC cord-354029-mp5r82g4 243 14 C c NN cord-354029-mp5r82g4 243 15 - - HYPH cord-354029-mp5r82g4 243 16 terminal terminal NN cord-354029-mp5r82g4 243 17 helices helix NNS cord-354029-mp5r82g4 243 18 of of IN cord-354029-mp5r82g4 243 19 paramyxovirus paramyxovirus NNP cord-354029-mp5r82g4 243 20 six six CD cord-354029-mp5r82g4 243 21 - - HYPH cord-354029-mp5r82g4 243 22 helix helix NN cord-354029-mp5r82g4 243 23 bundles bundle NNS cord-354029-mp5r82g4 243 24 are be VBP cord-354029-mp5r82g4 243 25 potent potent JJ cord-354029-mp5r82g4 243 26 inhibitors inhibitor NNS cord-354029-mp5r82g4 243 27 of of IN cord-354029-mp5r82g4 243 28 fusion fusion NN cord-354029-mp5r82g4 243 29 and and CC cord-354029-mp5r82g4 243 30 infection infection NN cord-354029-mp5r82g4 244 1 ( ( -LRB- cord-354029-mp5r82g4 244 2 Bossart Bossart NNP cord-354029-mp5r82g4 244 3 et et NNP cord-354029-mp5r82g4 244 4 al al NNP cord-354029-mp5r82g4 244 5 . . . cord-354029-mp5r82g4 245 1 2002 2002 CD cord-354029-mp5r82g4 245 2 ; ; : cord-354029-mp5r82g4 245 3 Joshi Joshi NNP cord-354029-mp5r82g4 245 4 et et FW cord-354029-mp5r82g4 245 5 al al NNP cord-354029-mp5r82g4 245 6 . . . cord-354029-mp5r82g4 246 1 1998 1998 CD cord-354029-mp5r82g4 246 2 ; ; : cord-354029-mp5r82g4 246 3 Lambert Lambert NNP cord-354029-mp5r82g4 246 4 et et NNP cord-354029-mp5r82g4 246 5 al al NNP cord-354029-mp5r82g4 246 6 . . . cord-354029-mp5r82g4 247 1 1996 1996 CD cord-354029-mp5r82g4 247 2 ; ; : cord-354029-mp5r82g4 247 3 Young Young NNP cord-354029-mp5r82g4 247 4 et et NNP cord-354029-mp5r82g4 247 5 al al NNP cord-354029-mp5r82g4 247 6 . . . cord-354029-mp5r82g4 247 7 1999 1999 CD cord-354029-mp5r82g4 247 8 ) ) -RRB- cord-354029-mp5r82g4 247 9 . . . cord-354029-mp5r82g4 248 1 As as IN cord-354029-mp5r82g4 248 2 is be VBZ cord-354029-mp5r82g4 248 3 also also RB cord-354029-mp5r82g4 248 4 the the DT cord-354029-mp5r82g4 248 5 case case NN cord-354029-mp5r82g4 248 6 for for IN cord-354029-mp5r82g4 248 7 HIV HIV NNP cord-354029-mp5r82g4 248 8 Env Env NNP cord-354029-mp5r82g4 248 9 Melikyan Melikyan NNP cord-354029-mp5r82g4 248 10 et et FW cord-354029-mp5r82g4 248 11 al al NNP cord-354029-mp5r82g4 248 12 . . NNP cord-354029-mp5r82g4 248 13 2000a 2000a CD cord-354029-mp5r82g4 248 14 ) ) -RRB- cord-354029-mp5r82g4 248 15 , , , cord-354029-mp5r82g4 248 16 a a DT cord-354029-mp5r82g4 248 17 recent recent JJ cord-354029-mp5r82g4 248 18 study study NN cord-354029-mp5r82g4 248 19 showed show VBD cord-354029-mp5r82g4 248 20 that that IN cord-354029-mp5r82g4 248 21 conversion conversion NN cord-354029-mp5r82g4 248 22 of of IN cord-354029-mp5r82g4 248 23 the the DT cord-354029-mp5r82g4 248 24 SV5 SV5 NNP cord-354029-mp5r82g4 248 25 F F NNP cord-354029-mp5r82g4 248 26 protein protein NN cord-354029-mp5r82g4 248 27 to to IN cord-354029-mp5r82g4 248 28 a a DT cord-354029-mp5r82g4 248 29 six six CD cord-354029-mp5r82g4 248 30 - - HYPH cord-354029-mp5r82g4 248 31 helix helix NN cord-354029-mp5r82g4 248 32 bundle bundle NN cord-354029-mp5r82g4 248 33 drives drive VBZ cord-354029-mp5r82g4 248 34 membrane membrane NN cord-354029-mp5r82g4 248 35 fusion fusion NN cord-354029-mp5r82g4 248 36 . . . cord-354029-mp5r82g4 249 1 Issues issue NNS cord-354029-mp5r82g4 249 2 yet yet RB cord-354029-mp5r82g4 249 3 to to TO cord-354029-mp5r82g4 249 4 be be VB cord-354029-mp5r82g4 249 5 addressed address VBN cord-354029-mp5r82g4 249 6 for for IN cord-354029-mp5r82g4 249 7 paramyxoviruses paramyxovirus NNS cord-354029-mp5r82g4 249 8 are be VBP cord-354029-mp5r82g4 249 9 the the DT cord-354029-mp5r82g4 249 10 structure structure NN cord-354029-mp5r82g4 249 11 of of IN cord-354029-mp5r82g4 249 12 the the DT cord-354029-mp5r82g4 249 13 complete complete JJ cord-354029-mp5r82g4 249 14 native native JJ cord-354029-mp5r82g4 249 15 ( ( -LRB- cord-354029-mp5r82g4 249 16 metastable metastable JJ cord-354029-mp5r82g4 249 17 ) ) -RRB- cord-354029-mp5r82g4 249 18 F f NN cord-354029-mp5r82g4 249 19 trimer trimer NN cord-354029-mp5r82g4 249 20 and and CC cord-354029-mp5r82g4 249 21 how how WRB cord-354029-mp5r82g4 249 22 it -PRON- PRP cord-354029-mp5r82g4 249 23 is be VBZ cord-354029-mp5r82g4 249 24 converted convert VBN cord-354029-mp5r82g4 249 25 to to IN cord-354029-mp5r82g4 249 26 its -PRON- PRP$ cord-354029-mp5r82g4 249 27 activated activate VBN cord-354029-mp5r82g4 249 28 form form NN cord-354029-mp5r82g4 249 29 . . . cord-354029-mp5r82g4 250 1 The the DT cord-354029-mp5r82g4 250 2 first first JJ cord-354029-mp5r82g4 250 3 glimpses glimpse NNS cord-354029-mp5r82g4 250 4 at at IN cord-354029-mp5r82g4 250 5 the the DT cord-354029-mp5r82g4 250 6 metastable metastable JJ cord-354029-mp5r82g4 250 7 and and CC cord-354029-mp5r82g4 250 8 postfusion postfusion NNP cord-354029-mp5r82g4 250 9 states state NNS cord-354029-mp5r82g4 250 10 of of IN cord-354029-mp5r82g4 250 11 the the DT cord-354029-mp5r82g4 250 12 F F NNP cord-354029-mp5r82g4 250 13 trimer trimer NN cord-354029-mp5r82g4 250 14 came come VBD cord-354029-mp5r82g4 250 15 from from IN cord-354029-mp5r82g4 250 16 EM EM NNP cord-354029-mp5r82g4 250 17 observations observation NNS cord-354029-mp5r82g4 250 18 of of IN cord-354029-mp5r82g4 250 19 the the DT cord-354029-mp5r82g4 250 20 respiratory respiratory JJ cord-354029-mp5r82g4 250 21 syncytial syncytial JJ cord-354029-mp5r82g4 250 22 virus virus NN cord-354029-mp5r82g4 250 23 ( ( -LRB- cord-354029-mp5r82g4 250 24 RSV RSV NNP cord-354029-mp5r82g4 250 25 ) ) -RRB- cord-354029-mp5r82g4 250 26 F F NNP cord-354029-mp5r82g4 250 27 protein protein NN cord-354029-mp5r82g4 250 28 . . . cord-354029-mp5r82g4 251 1 Preparations preparation NNS cord-354029-mp5r82g4 251 2 of of IN cord-354029-mp5r82g4 251 3 purified purify VBN cord-354029-mp5r82g4 251 4 recombinant recombinant JJ cord-354029-mp5r82g4 251 5 F F NNP cord-354029-mp5r82g4 251 6 protein protein NN cord-354029-mp5r82g4 251 7 contained contain VBD cord-354029-mp5r82g4 251 8 both both DT cord-354029-mp5r82g4 251 9 cone cone NN cord-354029-mp5r82g4 251 10 - - HYPH cord-354029-mp5r82g4 251 11 shaped shape VBN cord-354029-mp5r82g4 251 12 rods rod NNS cord-354029-mp5r82g4 251 13 and and CC cord-354029-mp5r82g4 251 14 " " `` cord-354029-mp5r82g4 251 15 lollipop"-shaped lollipop"-shaped JJ cord-354029-mp5r82g4 251 16 structures structure NNS cord-354029-mp5r82g4 251 17 . . . cord-354029-mp5r82g4 252 1 On on IN cord-354029-mp5r82g4 252 2 storage storage NN cord-354029-mp5r82g4 252 3 , , , cord-354029-mp5r82g4 252 4 there there EX cord-354029-mp5r82g4 252 5 appeared appear VBD cord-354029-mp5r82g4 252 6 to to TO cord-354029-mp5r82g4 252 7 be be VB cord-354029-mp5r82g4 252 8 a a DT cord-354029-mp5r82g4 252 9 shift shift NN cord-354029-mp5r82g4 252 10 from from IN cord-354029-mp5r82g4 252 11 the the DT cord-354029-mp5r82g4 252 12 cone cone NN cord-354029-mp5r82g4 252 13 - - HYPH cord-354029-mp5r82g4 252 14 shaped shape VBN cord-354029-mp5r82g4 252 15 to to IN cord-354029-mp5r82g4 252 16 the the DT cord-354029-mp5r82g4 252 17 " " `` cord-354029-mp5r82g4 252 18 lollipop"-shaped lollipop"-shaped JJ cord-354029-mp5r82g4 252 19 structures structure NNS cord-354029-mp5r82g4 252 20 ( ( -LRB- cord-354029-mp5r82g4 252 21 Calder Calder NNP cord-354029-mp5r82g4 252 22 et et NNP cord-354029-mp5r82g4 252 23 al al NNP cord-354029-mp5r82g4 252 24 . . . cord-354029-mp5r82g4 252 25 2000 2000 CD cord-354029-mp5r82g4 252 26 ) ) -RRB- cord-354029-mp5r82g4 252 27 . . . cord-354029-mp5r82g4 253 1 Examination examination NN cord-354029-mp5r82g4 253 2 of of IN cord-354029-mp5r82g4 253 3 F F NNP cord-354029-mp5r82g4 253 4 complexed complexed JJ cord-354029-mp5r82g4 253 5 with with IN cord-354029-mp5r82g4 253 6 specific specific JJ cord-354029-mp5r82g4 253 7 monoclonal monoclonal JJ cord-354029-mp5r82g4 253 8 antibodies antibody NNS cord-354029-mp5r82g4 253 9 suggested suggest VBD cord-354029-mp5r82g4 253 10 that that IN cord-354029-mp5r82g4 253 11 the the DT cord-354029-mp5r82g4 253 12 " " `` cord-354029-mp5r82g4 253 13 lollipop lollipop NN cord-354029-mp5r82g4 253 14 " " '' cord-354029-mp5r82g4 253 15 structures structure NNS cord-354029-mp5r82g4 253 16 contained contain VBD cord-354029-mp5r82g4 253 17 six six CD cord-354029-mp5r82g4 253 18 - - HYPH cord-354029-mp5r82g4 253 19 helix helix NN cord-354029-mp5r82g4 253 20 bundles bundle NNS cord-354029-mp5r82g4 253 21 composed compose VBN cord-354029-mp5r82g4 253 22 of of IN cord-354029-mp5r82g4 253 23 N n CD cord-354029-mp5r82g4 253 24 - - : cord-354029-mp5r82g4 253 25 and and CC cord-354029-mp5r82g4 253 26 C C NNP cord-354029-mp5r82g4 253 27 - - HYPH cord-354029-mp5r82g4 253 28 terminal terminal NN cord-354029-mp5r82g4 253 29 heptad heptad NN cord-354029-mp5r82g4 253 30 repeats repeat VBZ cord-354029-mp5r82g4 253 31 ( ( -LRB- cord-354029-mp5r82g4 253 32 Calder Calder NNP cord-354029-mp5r82g4 253 33 et et NNP cord-354029-mp5r82g4 253 34 al al NNP cord-354029-mp5r82g4 253 35 . . . cord-354029-mp5r82g4 253 36 2000 2000 CD cord-354029-mp5r82g4 253 37 ) ) -RRB- cord-354029-mp5r82g4 253 38 . . . cord-354029-mp5r82g4 254 1 A a DT cord-354029-mp5r82g4 254 2 high high JJ cord-354029-mp5r82g4 254 3 - - HYPH cord-354029-mp5r82g4 254 4 resolution resolution NN cord-354029-mp5r82g4 254 5 structure structure NN cord-354029-mp5r82g4 254 6 of of IN cord-354029-mp5r82g4 254 7 an an DT cord-354029-mp5r82g4 254 8 F F NNP cord-354029-mp5r82g4 254 9 protein protein NN cord-354029-mp5r82g4 254 10 ectodomain ectodomain NNP cord-354029-mp5r82g4 254 11 was be VBD cord-354029-mp5r82g4 254 12 recently recently RB cord-354029-mp5r82g4 254 13 presented present VBN cord-354029-mp5r82g4 255 1 ( ( -LRB- cord-354029-mp5r82g4 255 2 Chen Chen NNP cord-354029-mp5r82g4 255 3 et et NNP cord-354029-mp5r82g4 255 4 al al NNP cord-354029-mp5r82g4 255 5 . . NNP cord-354029-mp5r82g4 255 6 2001a 2001a CD cord-354029-mp5r82g4 255 7 ) ) -RRB- cord-354029-mp5r82g4 255 8 . . . cord-354029-mp5r82g4 256 1 The the DT cord-354029-mp5r82g4 256 2 protein protein NN cord-354029-mp5r82g4 256 3 used use VBD cord-354029-mp5r82g4 256 4 for for IN cord-354029-mp5r82g4 256 5 the the DT cord-354029-mp5r82g4 256 6 analysis analysis NN cord-354029-mp5r82g4 256 7 contained contain VBD cord-354029-mp5r82g4 256 8 a a DT cord-354029-mp5r82g4 256 9 mixture mixture NN cord-354029-mp5r82g4 256 10 of of IN cord-354029-mp5r82g4 256 11 precursor precursor NN cord-354029-mp5r82g4 256 12 F F NNP cord-354029-mp5r82g4 256 13 0 0 CD cord-354029-mp5r82g4 256 14 and and CC cord-354029-mp5r82g4 256 15 proteolytically proteolytically RB cord-354029-mp5r82g4 256 16 cleaved cleave VBN cord-354029-mp5r82g4 257 1 F. F. NNP cord-354029-mp5r82g4 257 2 It -PRON- PRP cord-354029-mp5r82g4 257 3 also also RB cord-354029-mp5r82g4 257 4 apparently apparently RB cord-354029-mp5r82g4 257 5 lacked lack VBD cord-354029-mp5r82g4 257 6 the the DT cord-354029-mp5r82g4 257 7 second second JJ cord-354029-mp5r82g4 257 8 heptad heptad NN cord-354029-mp5r82g4 257 9 repeat repeat NN cord-354029-mp5r82g4 257 10 , , , cord-354029-mp5r82g4 257 11 which which WDT cord-354029-mp5r82g4 257 12 forms form VBZ cord-354029-mp5r82g4 257 13 the the DT cord-354029-mp5r82g4 257 14 C C NNP cord-354029-mp5r82g4 257 15 - - HYPH cord-354029-mp5r82g4 257 16 helix helix NN cord-354029-mp5r82g4 257 17 in in IN cord-354029-mp5r82g4 257 18 the the DT cord-354029-mp5r82g4 257 19 postfusion postfusion NN cord-354029-mp5r82g4 257 20 form form NN cord-354029-mp5r82g4 257 21 . . . cord-354029-mp5r82g4 258 1 This this DT cord-354029-mp5r82g4 258 2 trimeric trimeric NNP cord-354029-mp5r82g4 258 3 F F NNP cord-354029-mp5r82g4 258 4 protein protein NN cord-354029-mp5r82g4 258 5 structure structure NN cord-354029-mp5r82g4 258 6 is be VBZ cord-354029-mp5r82g4 258 7 fundamentally fundamentally RB cord-354029-mp5r82g4 258 8 different different JJ cord-354029-mp5r82g4 258 9 from from IN cord-354029-mp5r82g4 258 10 that that DT cord-354029-mp5r82g4 258 11 of of IN cord-354029-mp5r82g4 258 12 influenza influenza NN cord-354029-mp5r82g4 258 13 HA HA NNP cord-354029-mp5r82g4 258 14 ; ; : cord-354029-mp5r82g4 258 15 the the DT cord-354029-mp5r82g4 258 16 N n CD cord-354029-mp5r82g4 258 17 - - HYPH cord-354029-mp5r82g4 258 18 terminal terminal JJ cord-354029-mp5r82g4 258 19 end end NN cord-354029-mp5r82g4 258 20 of of IN cord-354029-mp5r82g4 258 21 its -PRON- PRP$ cord-354029-mp5r82g4 258 22 coiled coiled JJ cord-354029-mp5r82g4 258 23 - - HYPH cord-354029-mp5r82g4 258 24 coil coil NN cord-354029-mp5r82g4 258 25 is be VBZ cord-354029-mp5r82g4 258 26 positioned position VBN cord-354029-mp5r82g4 258 27 near near IN cord-354029-mp5r82g4 258 28 the the DT cord-354029-mp5r82g4 258 29 viral viral JJ cord-354029-mp5r82g4 258 30 membrane membrane NN cord-354029-mp5r82g4 258 31 end end NN cord-354029-mp5r82g4 258 32 of of IN cord-354029-mp5r82g4 258 33 the the DT cord-354029-mp5r82g4 258 34 molecule molecule NN cord-354029-mp5r82g4 258 35 ( ( -LRB- cord-354029-mp5r82g4 258 36 i.e. i.e. FW cord-354029-mp5r82g4 258 37 , , , cord-354029-mp5r82g4 258 38 opposite opposite IN cord-354029-mp5r82g4 258 39 the the DT cord-354029-mp5r82g4 258 40 orientation orientation NN cord-354029-mp5r82g4 258 41 of of IN cord-354029-mp5r82g4 258 42 the the DT cord-354029-mp5r82g4 258 43 coiled coil VBN cord-354029-mp5r82g4 258 44 - - HYPH cord-354029-mp5r82g4 258 45 coil coil NN cord-354029-mp5r82g4 258 46 in in IN cord-354029-mp5r82g4 258 47 the the DT cord-354029-mp5r82g4 258 48 metastable metastable JJ cord-354029-mp5r82g4 258 49 HA HA NNP cord-354029-mp5r82g4 258 50 trimer trimer NN cord-354029-mp5r82g4 258 51 ) ) -RRB- cord-354029-mp5r82g4 258 52 . . . cord-354029-mp5r82g4 259 1 If if IN cord-354029-mp5r82g4 259 2 this this DT cord-354029-mp5r82g4 259 3 F F NNP cord-354029-mp5r82g4 259 4 protein protein NN cord-354029-mp5r82g4 259 5 structure structure NN cord-354029-mp5r82g4 259 6 represents represent VBZ cord-354029-mp5r82g4 259 7 the the DT cord-354029-mp5r82g4 259 8 native native JJ cord-354029-mp5r82g4 259 9 metastable metastable JJ cord-354029-mp5r82g4 259 10 F F NNP cord-354029-mp5r82g4 259 11 trimer trimer NN cord-354029-mp5r82g4 259 12 , , , cord-354029-mp5r82g4 259 13 then then RB cord-354029-mp5r82g4 259 14 it -PRON- PRP cord-354029-mp5r82g4 259 15 suggests suggest VBZ cord-354029-mp5r82g4 259 16 a a DT cord-354029-mp5r82g4 259 17 mechanism mechanism NN cord-354029-mp5r82g4 259 18 of of IN cord-354029-mp5r82g4 259 19 fusion fusion NN cord-354029-mp5r82g4 259 20 activation activation NN cord-354029-mp5r82g4 259 21 for for IN cord-354029-mp5r82g4 259 22 F F NNP cord-354029-mp5r82g4 259 23 fundamentally fundamentally RB cord-354029-mp5r82g4 259 24 different different JJ cord-354029-mp5r82g4 259 25 from from IN cord-354029-mp5r82g4 259 26 that that DT cord-354029-mp5r82g4 259 27 for for IN cord-354029-mp5r82g4 259 28 HA HA NNP cord-354029-mp5r82g4 260 1 ( ( -LRB- cord-354029-mp5r82g4 260 2 Chen Chen NNP cord-354029-mp5r82g4 260 3 et et NNP cord-354029-mp5r82g4 260 4 al al NNP cord-354029-mp5r82g4 260 5 . . NNP cord-354029-mp5r82g4 260 6 2001a 2001a CD cord-354029-mp5r82g4 260 7 ) ) -RRB- cord-354029-mp5r82g4 260 8 . . . cord-354029-mp5r82g4 261 1 Additional additional JJ cord-354029-mp5r82g4 261 2 work work NN cord-354029-mp5r82g4 261 3 is be VBZ cord-354029-mp5r82g4 261 4 needed need VBN cord-354029-mp5r82g4 261 5 to to TO cord-354029-mp5r82g4 261 6 test test VB cord-354029-mp5r82g4 261 7 this this DT cord-354029-mp5r82g4 261 8 idea idea NN cord-354029-mp5r82g4 261 9 . . . cord-354029-mp5r82g4 262 1 All all DT cord-354029-mp5r82g4 262 2 known know VBN cord-354029-mp5r82g4 262 3 class class NN cord-354029-mp5r82g4 262 4 II II NNP cord-354029-mp5r82g4 262 5 fusion fusion NN cord-354029-mp5r82g4 262 6 proteins protein NNS cord-354029-mp5r82g4 262 7 are be VBP cord-354029-mp5r82g4 262 8 activated activate VBN cord-354029-mp5r82g4 262 9 by by IN cord-354029-mp5r82g4 262 10 low low JJ cord-354029-mp5r82g4 262 11 pH. ph. NN cord-354029-mp5r82g4 263 1 However however RB cord-354029-mp5r82g4 263 2 , , , cord-354029-mp5r82g4 263 3 the the DT cord-354029-mp5r82g4 263 4 mechanism mechanism NN cord-354029-mp5r82g4 263 5 by by IN cord-354029-mp5r82g4 263 6 which which WDT cord-354029-mp5r82g4 263 7 class class NN cord-354029-mp5r82g4 263 8 II II NNP cord-354029-mp5r82g4 263 9 fusion fusion NN cord-354029-mp5r82g4 263 10 proteins protein NNS cord-354029-mp5r82g4 263 11 are be VBP cord-354029-mp5r82g4 263 12 initially initially RB cord-354029-mp5r82g4 263 13 activated activate VBN cord-354029-mp5r82g4 263 14 is be VBZ cord-354029-mp5r82g4 263 15 quite quite RB cord-354029-mp5r82g4 263 16 different different JJ cord-354029-mp5r82g4 263 17 than than IN cord-354029-mp5r82g4 263 18 the the DT cord-354029-mp5r82g4 263 19 mechanism mechanism NN cord-354029-mp5r82g4 263 20 by by IN cord-354029-mp5r82g4 263 21 which which WDT cord-354029-mp5r82g4 263 22 class class NN cord-354029-mp5r82g4 263 23 I -PRON- PRP cord-354029-mp5r82g4 263 24 fusion fusion NN cord-354029-mp5r82g4 263 25 proteins protein NNS cord-354029-mp5r82g4 263 26 are be VBP cord-354029-mp5r82g4 263 27 initially initially RB cord-354029-mp5r82g4 263 28 activated activate VBN cord-354029-mp5r82g4 263 29 . . . cord-354029-mp5r82g4 264 1 For for IN cord-354029-mp5r82g4 264 2 example example NN cord-354029-mp5r82g4 264 3 , , , cord-354029-mp5r82g4 264 4 the the DT cord-354029-mp5r82g4 264 5 ectodomain ectodomain NN cord-354029-mp5r82g4 264 6 of of IN cord-354029-mp5r82g4 264 7 the the DT cord-354029-mp5r82g4 264 8 TBE TBE NNP cord-354029-mp5r82g4 264 9 glycoprotein glycoprotein NN cord-354029-mp5r82g4 264 10 forms form VBZ cord-354029-mp5r82g4 264 11 an an DT cord-354029-mp5r82g4 264 12 antiparallel antiparallel JJ cord-354029-mp5r82g4 264 13 dimer dimer NN cord-354029-mp5r82g4 264 14 that that WDT cord-354029-mp5r82g4 264 15 lies lie VBZ cord-354029-mp5r82g4 264 16 parallel parallel JJ cord-354029-mp5r82g4 264 17 and and CC cord-354029-mp5r82g4 264 18 close close JJ cord-354029-mp5r82g4 264 19 to to IN cord-354029-mp5r82g4 264 20 the the DT cord-354029-mp5r82g4 264 21 viral viral JJ cord-354029-mp5r82g4 264 22 membrane membrane NN cord-354029-mp5r82g4 264 23 ( ( -LRB- cord-354029-mp5r82g4 264 24 Fig Fig NNP cord-354029-mp5r82g4 264 25 . . . cord-354029-mp5r82g4 264 26 4B 4b CD cord-354029-mp5r82g4 264 27 ) ) -RRB- cord-354029-mp5r82g4 264 28 . . . cord-354029-mp5r82g4 265 1 At at IN cord-354029-mp5r82g4 265 2 low low JJ cord-354029-mp5r82g4 265 3 pH ph NN cord-354029-mp5r82g4 265 4 , , , cord-354029-mp5r82g4 265 5 the the DT cord-354029-mp5r82g4 265 6 TBE TBE NNP cord-354029-mp5r82g4 265 7 E e NN cord-354029-mp5r82g4 265 8 homodimer homodimer NN cord-354029-mp5r82g4 265 9 converts convert VBZ cord-354029-mp5r82g4 265 10 to to IN cord-354029-mp5r82g4 265 11 an an DT cord-354029-mp5r82g4 265 12 E e NN cord-354029-mp5r82g4 265 13 homotrimer homotrimer NN cord-354029-mp5r82g4 265 14 ( ( -LRB- cord-354029-mp5r82g4 265 15 Allison Allison NNP cord-354029-mp5r82g4 265 16 et et NNP cord-354029-mp5r82g4 265 17 al al NNP cord-354029-mp5r82g4 265 18 . . NNP cord-354029-mp5r82g4 265 19 1995 1995 CD cord-354029-mp5r82g4 265 20 ; ; : cord-354029-mp5r82g4 265 21 Heinz Heinz NNP cord-354029-mp5r82g4 265 22 and and CC cord-354029-mp5r82g4 265 23 Allison Allison NNP cord-354029-mp5r82g4 265 24 2001 2001 CD cord-354029-mp5r82g4 265 25 ; ; : cord-354029-mp5r82g4 265 26 Stiasny Stiasny NNP cord-354029-mp5r82g4 265 27 et et NNP cord-354029-mp5r82g4 265 28 al al NNP cord-354029-mp5r82g4 265 29 . . NNP cord-354029-mp5r82g4 265 30 2001 2001 CD cord-354029-mp5r82g4 265 31 ) ) -RRB- cord-354029-mp5r82g4 265 32 . . . cord-354029-mp5r82g4 266 1 This this DT cord-354029-mp5r82g4 266 2 transformation transformation NN cord-354029-mp5r82g4 266 3 is be VBZ cord-354029-mp5r82g4 266 4 thought think VBN cord-354029-mp5r82g4 266 5 to to TO cord-354029-mp5r82g4 266 6 occur occur VB cord-354029-mp5r82g4 266 7 in in IN cord-354029-mp5r82g4 266 8 two two CD cord-354029-mp5r82g4 266 9 steps step NNS cord-354029-mp5r82g4 266 10 : : : cord-354029-mp5r82g4 266 11 dissociation dissociation NN cord-354029-mp5r82g4 266 12 of of IN cord-354029-mp5r82g4 266 13 the the DT cord-354029-mp5r82g4 266 14 E e NN cord-354029-mp5r82g4 266 15 homodimer homodimer NN cord-354029-mp5r82g4 266 16 , , , cord-354029-mp5r82g4 266 17 followed follow VBN cord-354029-mp5r82g4 266 18 by by IN cord-354029-mp5r82g4 266 19 reassociation reassociation NN cord-354029-mp5r82g4 266 20 of of IN cord-354029-mp5r82g4 266 21 E E NNP cord-354029-mp5r82g4 266 22 trimers trimer NNS cord-354029-mp5r82g4 266 23 ( ( -LRB- cord-354029-mp5r82g4 266 24 Stiasny Stiasny NNP cord-354029-mp5r82g4 266 25 et et NNP cord-354029-mp5r82g4 266 26 al al NNP cord-354029-mp5r82g4 266 27 . . . cord-354029-mp5r82g4 266 28 1996 1996 CD cord-354029-mp5r82g4 266 29 ) ) -RRB- cord-354029-mp5r82g4 266 30 . . . cord-354029-mp5r82g4 267 1 Membrane membrane NN cord-354029-mp5r82g4 267 2 binding binding NN cord-354029-mp5r82g4 267 3 occurs occur VBZ cord-354029-mp5r82g4 267 4 after after IN cord-354029-mp5r82g4 267 5 dimer dimer NN cord-354029-mp5r82g4 267 6 dissociation dissociation NN cord-354029-mp5r82g4 267 7 and and CC cord-354029-mp5r82g4 267 8 promotes promote VBZ cord-354029-mp5r82g4 267 9 the the DT cord-354029-mp5r82g4 267 10 formation formation NN cord-354029-mp5r82g4 267 11 of of IN cord-354029-mp5r82g4 267 12 E e NN cord-354029-mp5r82g4 267 13 homotrimers homotrimer NNS cord-354029-mp5r82g4 267 14 ( ( -LRB- cord-354029-mp5r82g4 267 15 Stiasny Stiasny NNP cord-354029-mp5r82g4 267 16 et et NNP cord-354029-mp5r82g4 267 17 al al NNP cord-354029-mp5r82g4 267 18 . . . cord-354029-mp5r82g4 267 19 2002 2002 CD cord-354029-mp5r82g4 267 20 ) ) -RRB- cord-354029-mp5r82g4 267 21 . . . cord-354029-mp5r82g4 268 1 Homotrimer Homotrimer NNP cord-354029-mp5r82g4 268 2 formation formation NN cord-354029-mp5r82g4 268 3 may may MD cord-354029-mp5r82g4 268 4 involve involve VB cord-354029-mp5r82g4 268 5 interactions interaction NNS cord-354029-mp5r82g4 268 6 between between IN cord-354029-mp5r82g4 268 7 a a DT cord-354029-mp5r82g4 268 8 - - : cord-354029-mp5r82g4 268 9 helices helix NNS cord-354029-mp5r82g4 268 10 in in IN cord-354029-mp5r82g4 268 11 the the DT cord-354029-mp5r82g4 268 12 stem stem NN cord-354029-mp5r82g4 268 13 region region NN cord-354029-mp5r82g4 268 14 of of IN cord-354029-mp5r82g4 268 15 the the DT cord-354029-mp5r82g4 268 16 E e NN cord-354029-mp5r82g4 268 17 protein protein NN cord-354029-mp5r82g4 268 18 ( ( -LRB- cord-354029-mp5r82g4 268 19 Allison Allison NNP cord-354029-mp5r82g4 268 20 et et NNP cord-354029-mp5r82g4 268 21 al al NNP cord-354029-mp5r82g4 268 22 . . . cord-354029-mp5r82g4 268 23 1999 1999 CD cord-354029-mp5r82g4 268 24 ) ) -RRB- cord-354029-mp5r82g4 268 25 . . . cord-354029-mp5r82g4 269 1 The the DT cord-354029-mp5r82g4 269 2 SFV SFV NNP cord-354029-mp5r82g4 269 3 fusion fusion NN cord-354029-mp5r82g4 269 4 protein protein NN cord-354029-mp5r82g4 269 5 also also RB cord-354029-mp5r82g4 269 6 converts convert VBZ cord-354029-mp5r82g4 269 7 from from IN cord-354029-mp5r82g4 269 8 a a DT cord-354029-mp5r82g4 269 9 dimer dimer NN cord-354029-mp5r82g4 269 10 to to IN cord-354029-mp5r82g4 269 11 a a DT cord-354029-mp5r82g4 269 12 trimer trimer NN cord-354029-mp5r82g4 269 13 during during IN cord-354029-mp5r82g4 269 14 fusion fusion NN cord-354029-mp5r82g4 269 15 activation activation NN cord-354029-mp5r82g4 269 16 . . . cord-354029-mp5r82g4 270 1 On on IN cord-354029-mp5r82g4 270 2 native native JJ cord-354029-mp5r82g4 270 3 virions virion NNS cord-354029-mp5r82g4 270 4 , , , cord-354029-mp5r82g4 270 5 E1 E1 NNP cord-354029-mp5r82g4 270 6 exists exist VBZ cord-354029-mp5r82g4 270 7 as as IN cord-354029-mp5r82g4 270 8 a a DT cord-354029-mp5r82g4 270 9 tight tight JJ cord-354029-mp5r82g4 270 10 heterodimeric heterodimeric JJ cord-354029-mp5r82g4 270 11 complex complex NN cord-354029-mp5r82g4 270 12 with with IN cord-354029-mp5r82g4 270 13 a a DT cord-354029-mp5r82g4 270 14 second second JJ cord-354029-mp5r82g4 270 15 membrane membrane NN cord-354029-mp5r82g4 270 16 protein protein NN cord-354029-mp5r82g4 270 17 , , , cord-354029-mp5r82g4 270 18 E2 E2 NNP cord-354029-mp5r82g4 270 19 . . . cord-354029-mp5r82g4 271 1 On on IN cord-354029-mp5r82g4 271 2 exposure exposure NN cord-354029-mp5r82g4 271 3 to to IN cord-354029-mp5r82g4 271 4 low low JJ cord-354029-mp5r82g4 271 5 pH ph NN cord-354029-mp5r82g4 271 6 , , , cord-354029-mp5r82g4 271 7 E1 E1 NNP cord-354029-mp5r82g4 271 8 dissociates dissociate VBZ cord-354029-mp5r82g4 271 9 from from IN cord-354029-mp5r82g4 271 10 E2 E2 NNP cord-354029-mp5r82g4 271 11 , , , cord-354029-mp5r82g4 271 12 changes change VBZ cord-354029-mp5r82g4 271 13 conformation conformation NN cord-354029-mp5r82g4 271 14 , , , cord-354029-mp5r82g4 271 15 and and CC cord-354029-mp5r82g4 271 16 forms form NNS cord-354029-mp5r82g4 271 17 highly highly RB cord-354029-mp5r82g4 271 18 stable stable JJ cord-354029-mp5r82g4 271 19 E1 e1 NN cord-354029-mp5r82g4 271 20 homotrimers homotrimer NNS cord-354029-mp5r82g4 271 21 ( ( -LRB- cord-354029-mp5r82g4 271 22 Ahn Ahn NNP cord-354029-mp5r82g4 271 23 et et NNP cord-354029-mp5r82g4 271 24 al al NNP cord-354029-mp5r82g4 271 25 . . . cord-354029-mp5r82g4 271 26 1999 1999 CD cord-354029-mp5r82g4 271 27 ; ; : cord-354029-mp5r82g4 271 28 Kielian kielian JJ cord-354029-mp5r82g4 271 29 1995 1995 CD cord-354029-mp5r82g4 271 30 ; ; : cord-354029-mp5r82g4 271 31 . . . cord-354029-mp5r82g4 272 1 During during IN cord-354029-mp5r82g4 272 2 this this DT cord-354029-mp5r82g4 272 3 process process NN cord-354029-mp5r82g4 272 4 , , , cord-354029-mp5r82g4 272 5 E1 E1 NNP cord-354029-mp5r82g4 272 6 binds bind VBZ cord-354029-mp5r82g4 272 7 hydrophobically hydrophobically RB cord-354029-mp5r82g4 272 8 through through IN cord-354029-mp5r82g4 272 9 its -PRON- PRP$ cord-354029-mp5r82g4 272 10 fusion fusion NN cord-354029-mp5r82g4 272 11 peptide peptide NN cord-354029-mp5r82g4 272 12 to to TO cord-354029-mp5r82g4 272 13 target target VB cord-354029-mp5r82g4 272 14 membranes membrane NNS cord-354029-mp5r82g4 272 15 and and CC cord-354029-mp5r82g4 272 16 mediates mediate VBZ cord-354029-mp5r82g4 272 17 fu fu NN cord-354029-mp5r82g4 272 18 - - HYPH cord-354029-mp5r82g4 272 19 sion sion NN cord-354029-mp5r82g4 272 20 . . . cord-354029-mp5r82g4 273 1 Similar similar JJ cord-354029-mp5r82g4 273 2 to to IN cord-354029-mp5r82g4 273 3 TBE TBE NNP cord-354029-mp5r82g4 273 4 E E NNP cord-354029-mp5r82g4 273 5 , , , cord-354029-mp5r82g4 273 6 it -PRON- PRP cord-354029-mp5r82g4 273 7 appears appear VBZ cord-354029-mp5r82g4 273 8 that that IN cord-354029-mp5r82g4 273 9 binding bind VBG cord-354029-mp5r82g4 273 10 to to IN cord-354029-mp5r82g4 273 11 the the DT cord-354029-mp5r82g4 273 12 target target NN cord-354029-mp5r82g4 273 13 bilayer bilayer NN cord-354029-mp5r82g4 273 14 fosters foster VBZ cord-354029-mp5r82g4 273 15 formation formation NN cord-354029-mp5r82g4 273 16 of of IN cord-354029-mp5r82g4 273 17 the the DT cord-354029-mp5r82g4 273 18 activated activate VBN cord-354029-mp5r82g4 273 19 E1 E1 NNP cord-354029-mp5r82g4 273 20 homotrimer homotrimer NNP cord-354029-mp5r82g4 273 21 ( ( -LRB- cord-354029-mp5r82g4 273 22 Kielian kielian JJ cord-354029-mp5r82g4 273 23 1995 1995 CD cord-354029-mp5r82g4 273 24 ; ; : cord-354029-mp5r82g4 273 25 Kielian Kielian NNP cord-354029-mp5r82g4 273 26 et et NNP cord-354029-mp5r82g4 273 27 al al NNP cord-354029-mp5r82g4 273 28 . . . cord-354029-mp5r82g4 273 29 2000 2000 CD cord-354029-mp5r82g4 273 30 ) ) -RRB- cord-354029-mp5r82g4 273 31 ; ; : cord-354029-mp5r82g4 273 32 the the DT cord-354029-mp5r82g4 273 33 fusion fusion NN cord-354029-mp5r82g4 273 34 peptide peptide NN cord-354029-mp5r82g4 273 35 and and CC cord-354029-mp5r82g4 273 36 the the DT cord-354029-mp5r82g4 273 37 transmembrane transmembrane NN cord-354029-mp5r82g4 273 38 domain domain NN cord-354029-mp5r82g4 273 39 of of IN cord-354029-mp5r82g4 273 40 E1 e1 NN cord-354029-mp5r82g4 273 41 appear appear VBP cord-354029-mp5r82g4 273 42 to to TO cord-354029-mp5r82g4 273 43 be be VB cord-354029-mp5r82g4 273 44 important important JJ cord-354029-mp5r82g4 273 45 for for IN cord-354029-mp5r82g4 273 46 E1 E1 NNP cord-354029-mp5r82g4 273 47 homotrimer homotrimer NNP cord-354029-mp5r82g4 273 48 formation formation NN cord-354029-mp5r82g4 274 1 ( ( -LRB- cord-354029-mp5r82g4 274 2 Kielian Kielian NNP cord-354029-mp5r82g4 274 3 et et NNP cord-354029-mp5r82g4 274 4 al al NNP cord-354029-mp5r82g4 274 5 . . . cord-354029-mp5r82g4 275 1 1996 1996 CD cord-354029-mp5r82g4 276 1 ( ( -LRB- cord-354029-mp5r82g4 276 2 Kielian Kielian NNP cord-354029-mp5r82g4 276 3 et et NNP cord-354029-mp5r82g4 276 4 al al NNP cord-354029-mp5r82g4 276 5 . . . cord-354029-mp5r82g4 277 1 , , , cord-354029-mp5r82g4 277 2 2000 2000 CD cord-354029-mp5r82g4 277 3 Sjoberg Sjoberg NNP cord-354029-mp5r82g4 277 4 and and CC cord-354029-mp5r82g4 277 5 Garoff Garoff NNP cord-354029-mp5r82g4 277 6 2003 2003 CD cord-354029-mp5r82g4 277 7 ) ) -RRB- cord-354029-mp5r82g4 277 8 . . . cord-354029-mp5r82g4 278 1 Thus thus RB cord-354029-mp5r82g4 278 2 both both DT cord-354029-mp5r82g4 278 3 class class NN cord-354029-mp5r82g4 278 4 I i NN cord-354029-mp5r82g4 278 5 and and CC cord-354029-mp5r82g4 278 6 class class NN cord-354029-mp5r82g4 278 7 II ii CD cord-354029-mp5r82g4 278 8 viral viral JJ cord-354029-mp5r82g4 278 9 fusion fusion NN cord-354029-mp5r82g4 278 10 proteins protein NNS cord-354029-mp5r82g4 278 11 appear appear VBP cord-354029-mp5r82g4 278 12 to to TO cord-354029-mp5r82g4 278 13 function function VB cord-354029-mp5r82g4 278 14 as as IN cord-354029-mp5r82g4 278 15 trimers trimer NNS cord-354029-mp5r82g4 278 16 during during IN cord-354029-mp5r82g4 278 17 fusion fusion NN cord-354029-mp5r82g4 278 18 . . . cord-354029-mp5r82g4 279 1 It -PRON- PRP cord-354029-mp5r82g4 279 2 has have VBZ cord-354029-mp5r82g4 279 3 been be VBN cord-354029-mp5r82g4 279 4 proposed propose VBN cord-354029-mp5r82g4 279 5 that that IN cord-354029-mp5r82g4 279 6 activated activate VBN cord-354029-mp5r82g4 279 7 TBE TBE NNP cord-354029-mp5r82g4 279 8 E e NN cord-354029-mp5r82g4 279 9 ( ( -LRB- cord-354029-mp5r82g4 279 10 Helenius Helenius NNP cord-354029-mp5r82g4 279 11 1995 1995 CD cord-354029-mp5r82g4 279 12 ) ) -RRB- cord-354029-mp5r82g4 279 13 and and CC cord-354029-mp5r82g4 279 14 SFV SFV NNP cord-354029-mp5r82g4 279 15 E1 E1 NNP cord-354029-mp5r82g4 279 16 stand stand VBP cord-354029-mp5r82g4 279 17 up up RP cord-354029-mp5r82g4 279 18 as as IN cord-354029-mp5r82g4 279 19 trimeric trimeric JJ cord-354029-mp5r82g4 279 20 spikes spike NNS cord-354029-mp5r82g4 279 21 and and CC cord-354029-mp5r82g4 279 22 present present VBP cord-354029-mp5r82g4 279 23 their -PRON- PRP$ cord-354029-mp5r82g4 279 24 fusion fusion NN cord-354029-mp5r82g4 279 25 peptides peptide NNS cord-354029-mp5r82g4 279 26 to to IN cord-354029-mp5r82g4 279 27 the the DT cord-354029-mp5r82g4 279 28 target target NN cord-354029-mp5r82g4 279 29 membrane membrane NN cord-354029-mp5r82g4 279 30 ( ( -LRB- cord-354029-mp5r82g4 279 31 Fig Fig NNP cord-354029-mp5r82g4 279 32 . . . cord-354029-mp5r82g4 279 33 4B 4b CD cord-354029-mp5r82g4 279 34 , , , cord-354029-mp5r82g4 279 35 right right RB cord-354029-mp5r82g4 279 36 ) ) -RRB- cord-354029-mp5r82g4 279 37 . . . cord-354029-mp5r82g4 280 1 This this DT cord-354029-mp5r82g4 280 2 would would MD cord-354029-mp5r82g4 280 3 be be VB cord-354029-mp5r82g4 280 4 analogous analogous JJ cord-354029-mp5r82g4 280 5 to to IN cord-354029-mp5r82g4 280 6 Fig Fig NNP cord-354029-mp5r82g4 280 7 . . . cord-354029-mp5r82g4 281 1 3 3 LS cord-354029-mp5r82g4 281 2 , , , cord-354029-mp5r82g4 281 3 Step step NN cord-354029-mp5r82g4 281 4 1 1 CD cord-354029-mp5r82g4 281 5 . . . cord-354029-mp5r82g4 282 1 If if IN cord-354029-mp5r82g4 282 2 this this DT cord-354029-mp5r82g4 282 3 occurs occur VBZ cord-354029-mp5r82g4 282 4 , , , cord-354029-mp5r82g4 282 5 ( ( -LRB- cord-354029-mp5r82g4 282 6 Kuhm Kuhm NNP cord-354029-mp5r82g4 282 7 et et NNP cord-354029-mp5r82g4 282 8 al al NNP cord-354029-mp5r82g4 282 9 . . . cord-354029-mp5r82g4 282 10 2002 2002 CD cord-354029-mp5r82g4 282 11 ) ) -RRB- cord-354029-mp5r82g4 282 12 . . . cord-354029-mp5r82g4 283 1 Note note VB cord-354029-mp5r82g4 283 2 that that IN cord-354029-mp5r82g4 283 3 other other JJ cord-354029-mp5r82g4 283 4 possibilities possibility NNS cord-354029-mp5r82g4 283 5 for for IN cord-354029-mp5r82g4 283 6 the the DT cord-354029-mp5r82g4 283 7 dimer dimer NN cord-354029-mp5r82g4 283 8 to to IN cord-354029-mp5r82g4 283 9 trimer trimer NN cord-354029-mp5r82g4 283 10 transition transition NN cord-354029-mp5r82g4 283 11 exist exist VBP cord-354029-mp5r82g4 283 12 ( ( -LRB- cord-354029-mp5r82g4 283 13 for for IN cord-354029-mp5r82g4 283 14 example example NN cord-354029-mp5r82g4 283 15 involving involve VBG cord-354029-mp5r82g4 283 16 relative relative JJ cord-354029-mp5r82g4 283 17 movements movement NNS cord-354029-mp5r82g4 283 18 of of IN cord-354029-mp5r82g4 283 19 domains domain NNS cord-354029-mp5r82g4 283 20 about about IN cord-354029-mp5r82g4 283 21 hinge hinge NN cord-354029-mp5r82g4 283 22 regions region NNS cord-354029-mp5r82g4 283 23 ) ) -RRB- cord-354029-mp5r82g4 283 24 . . . cord-354029-mp5r82g4 284 1 For for IN cord-354029-mp5r82g4 284 2 very very RB cord-354029-mp5r82g4 284 3 recent recent JJ cord-354029-mp5r82g4 284 4 developments development NNS cord-354029-mp5r82g4 284 5 regarding regard VBG cord-354029-mp5r82g4 284 6 the the DT cord-354029-mp5r82g4 284 7 fusion fusion NN cord-354029-mp5r82g4 284 8 mechanism mechanism NN cord-354029-mp5r82g4 284 9 of of IN cord-354029-mp5r82g4 284 10 class class NN cord-354029-mp5r82g4 284 11 II II NNP cord-354029-mp5r82g4 284 12 fusion fusion NN cord-354029-mp5r82g4 284 13 proteins protein NNS cord-354029-mp5r82g4 284 14 , , , cord-354029-mp5r82g4 284 15 see see VB cord-354029-mp5r82g4 284 16 Bressanelli Bressanelli NNP cord-354029-mp5r82g4 284 17 et et NNP cord-354029-mp5r82g4 284 18 al al NNP cord-354029-mp5r82g4 284 19 . . . cord-354029-mp5r82g4 285 1 ( ( -LRB- cord-354029-mp5r82g4 285 2 2004 2004 CD cord-354029-mp5r82g4 285 3 ) ) -RRB- cord-354029-mp5r82g4 285 4 , , , cord-354029-mp5r82g4 285 5 Gibbons Gibbons NNP cord-354029-mp5r82g4 285 6 et et NNP cord-354029-mp5r82g4 285 7 al al NNP cord-354029-mp5r82g4 285 8 . . . cord-354029-mp5r82g4 286 1 ( ( -LRB- cord-354029-mp5r82g4 286 2 2004 2004 CD cord-354029-mp5r82g4 286 3 ) ) -RRB- cord-354029-mp5r82g4 286 4 and and CC cord-354029-mp5r82g4 286 5 Modis Modis NNP cord-354029-mp5r82g4 286 6 et et NNP cord-354029-mp5r82g4 286 7 al al NNP cord-354029-mp5r82g4 286 8 . . . cord-354029-mp5r82g4 287 1 ( ( -LRB- cord-354029-mp5r82g4 287 2 2004 2004 CD cord-354029-mp5r82g4 287 3 ) ) -RRB- cord-354029-mp5r82g4 287 4 then then RB cord-354029-mp5r82g4 287 5 the the DT cord-354029-mp5r82g4 287 6 spike spike NN cord-354029-mp5r82g4 287 7 would would MD cord-354029-mp5r82g4 287 8 have have VB cord-354029-mp5r82g4 287 9 to to TO cord-354029-mp5r82g4 287 10 refold refold VB cord-354029-mp5r82g4 287 11 to to TO cord-354029-mp5r82g4 287 12 bring bring VB cord-354029-mp5r82g4 287 13 the the DT cord-354029-mp5r82g4 287 14 viral viral JJ cord-354029-mp5r82g4 287 15 and and CC cord-354029-mp5r82g4 287 16 cellular cellular JJ cord-354029-mp5r82g4 287 17 membranes membrane NNS cord-354029-mp5r82g4 287 18 together together RB cord-354029-mp5r82g4 288 1 ( ( -LRB- cord-354029-mp5r82g4 288 2 e.g. e.g. RB cord-354029-mp5r82g4 288 3 , , , cord-354029-mp5r82g4 288 4 analogous analogous JJ cord-354029-mp5r82g4 288 5 to to IN cord-354029-mp5r82g4 288 6 Steps step NNS cord-354029-mp5r82g4 288 7 4 4 CD cord-354029-mp5r82g4 288 8 and and CC cord-354029-mp5r82g4 288 9 5 5 CD cord-354029-mp5r82g4 288 10 in in IN cord-354029-mp5r82g4 288 11 Fig Fig NNP cord-354029-mp5r82g4 288 12 . . . cord-354029-mp5r82g4 288 13 3 3 CD cord-354029-mp5r82g4 288 14 ) ) -RRB- cord-354029-mp5r82g4 288 15 . . . cord-354029-mp5r82g4 289 1 Very very RB cord-354029-mp5r82g4 289 2 recent recent JJ cord-354029-mp5r82g4 289 3 evidence evidence NN cord-354029-mp5r82g4 289 4 indicates indicate VBZ cord-354029-mp5r82g4 289 5 that that IN cord-354029-mp5r82g4 289 6 this this DT cord-354029-mp5r82g4 289 7 is be VBZ cord-354029-mp5r82g4 289 8 , , , cord-354029-mp5r82g4 289 9 indeed indeed RB cord-354029-mp5r82g4 289 10 , , , cord-354029-mp5r82g4 289 11 the the DT cord-354029-mp5r82g4 289 12 case case NN cord-354029-mp5r82g4 289 13 ( ( -LRB- cord-354029-mp5r82g4 289 14 Bressanelli Bressanelli NNP cord-354029-mp5r82g4 289 15 et et NNP cord-354029-mp5r82g4 289 16 al al NNP cord-354029-mp5r82g4 289 17 . . . cord-354029-mp5r82g4 289 18 2004 2004 CD cord-354029-mp5r82g4 289 19 ; ; : cord-354029-mp5r82g4 289 20 Gibbons Gibbons NNP cord-354029-mp5r82g4 289 21 et et NNP cord-354029-mp5r82g4 289 22 al al NNP cord-354029-mp5r82g4 289 23 . . . cord-354029-mp5r82g4 289 24 2004 2004 CD cord-354029-mp5r82g4 289 25 ; ; : cord-354029-mp5r82g4 289 26 Modis Modis NNP cord-354029-mp5r82g4 289 27 et et NNP cord-354029-mp5r82g4 289 28 al al NNP cord-354029-mp5r82g4 289 29 . . . cord-354029-mp5r82g4 289 30 2004 2004 CD cord-354029-mp5r82g4 289 31 ) ) -RRB- cord-354029-mp5r82g4 289 32 . . . cord-354029-mp5r82g4 290 1 Thus thus RB cord-354029-mp5r82g4 290 2 far far RB cord-354029-mp5r82g4 290 3 we -PRON- PRP cord-354029-mp5r82g4 290 4 have have VBP cord-354029-mp5r82g4 290 5 focused focus VBN cord-354029-mp5r82g4 290 6 on on IN cord-354029-mp5r82g4 290 7 the the DT cord-354029-mp5r82g4 290 8 conditions condition NNS cord-354029-mp5r82g4 290 9 that that WDT cord-354029-mp5r82g4 290 10 elicit elicit VBP cord-354029-mp5r82g4 290 11 viral viral JJ cord-354029-mp5r82g4 290 12 fusion fusion NN cord-354029-mp5r82g4 290 13 reactions reaction NNS cord-354029-mp5r82g4 290 14 and and CC cord-354029-mp5r82g4 290 15 the the DT cord-354029-mp5r82g4 290 16 conformational conformational JJ cord-354029-mp5r82g4 290 17 changes change NNS cord-354029-mp5r82g4 290 18 in in IN cord-354029-mp5r82g4 290 19 viral viral JJ cord-354029-mp5r82g4 290 20 fusion fusion NN cord-354029-mp5r82g4 290 21 proteins protein NNS cord-354029-mp5r82g4 290 22 necessary necessary JJ cord-354029-mp5r82g4 290 23 for for IN cord-354029-mp5r82g4 290 24 fusion fusion NN cord-354029-mp5r82g4 290 25 . . . cord-354029-mp5r82g4 291 1 However however RB cord-354029-mp5r82g4 291 2 , , , cord-354029-mp5r82g4 291 3 it -PRON- PRP cord-354029-mp5r82g4 291 4 is be VBZ cord-354029-mp5r82g4 291 5 the the DT cord-354029-mp5r82g4 291 6 viral viral JJ cord-354029-mp5r82g4 291 7 and and CC cord-354029-mp5r82g4 291 8 cellular cellular JJ cord-354029-mp5r82g4 291 9 bilayer bilayer NN cord-354029-mp5r82g4 291 10 membranes membrane NNS cord-354029-mp5r82g4 291 11 that that WDT cord-354029-mp5r82g4 291 12 merge merge VBP cord-354029-mp5r82g4 291 13 during during IN cord-354029-mp5r82g4 291 14 fusion fusion NN cord-354029-mp5r82g4 291 15 . . . cord-354029-mp5r82g4 292 1 Lipid lipid NN cord-354029-mp5r82g4 292 2 bilayers bilayer NNS cord-354029-mp5r82g4 292 3 are be VBP cord-354029-mp5r82g4 292 4 stable stable JJ cord-354029-mp5r82g4 292 5 structures structure NNS cord-354029-mp5r82g4 292 6 that that WDT cord-354029-mp5r82g4 292 7 do do VBP cord-354029-mp5r82g4 292 8 not not RB cord-354029-mp5r82g4 292 9 fuse fuse VB cord-354029-mp5r82g4 292 10 spontaneously spontaneously RB cord-354029-mp5r82g4 292 11 . . . cord-354029-mp5r82g4 293 1 Fusion fusion NN cord-354029-mp5r82g4 293 2 proteins protein NNS cord-354029-mp5r82g4 293 3 have have VBP cord-354029-mp5r82g4 293 4 evolved evolve VBN cord-354029-mp5r82g4 293 5 to to TO cord-354029-mp5r82g4 293 6 catalyze catalyze VB cord-354029-mp5r82g4 293 7 the the DT cord-354029-mp5r82g4 293 8 necessary necessary JJ cord-354029-mp5r82g4 293 9 lipid lipid NN cord-354029-mp5r82g4 293 10 rearrangements rearrangement NNS cord-354029-mp5r82g4 293 11 . . . cord-354029-mp5r82g4 294 1 We -PRON- PRP cord-354029-mp5r82g4 294 2 now now RB cord-354029-mp5r82g4 294 3 review review VBP cord-354029-mp5r82g4 294 4 a a DT cord-354029-mp5r82g4 294 5 lipid lipid NN cord-354029-mp5r82g4 294 6 rearrangement rearrangement NN cord-354029-mp5r82g4 294 7 model model NN cord-354029-mp5r82g4 294 8 and and CC cord-354029-mp5r82g4 294 9 focus focus VB cord-354029-mp5r82g4 294 10 on on IN cord-354029-mp5r82g4 294 11 the the DT cord-354029-mp5r82g4 294 12 roles role NNS cord-354029-mp5r82g4 294 13 of of IN cord-354029-mp5r82g4 294 14 different different JJ cord-354029-mp5r82g4 294 15 regions region NNS cord-354029-mp5r82g4 294 16 of of IN cord-354029-mp5r82g4 294 17 viral viral JJ cord-354029-mp5r82g4 294 18 fusion fusion NN cord-354029-mp5r82g4 294 19 proteins protein NNS cord-354029-mp5r82g4 294 20 in in IN cord-354029-mp5r82g4 294 21 choreographing choreograph VBG cord-354029-mp5r82g4 294 22 the the DT cord-354029-mp5r82g4 294 23 structural structural JJ cord-354029-mp5r82g4 294 24 changes change NNS cord-354029-mp5r82g4 294 25 that that WDT cord-354029-mp5r82g4 294 26 the the DT cord-354029-mp5r82g4 294 27 membranes membrane NNS cord-354029-mp5r82g4 294 28 undergo undergo VBP cord-354029-mp5r82g4 294 29 throughout throughout IN cord-354029-mp5r82g4 294 30 the the DT cord-354029-mp5r82g4 294 31 fusion fusion NN cord-354029-mp5r82g4 294 32 cascade cascade NN cord-354029-mp5r82g4 294 33 ( ( -LRB- cord-354029-mp5r82g4 294 34 Fig Fig NNP cord-354029-mp5r82g4 294 35 . . . cord-354029-mp5r82g4 294 36 3 3 CD cord-354029-mp5r82g4 294 37 ) ) -RRB- cord-354029-mp5r82g4 294 38 . . . cord-354029-mp5r82g4 295 1 The the DT cord-354029-mp5r82g4 295 2 favored favored JJ cord-354029-mp5r82g4 295 3 model model NN cord-354029-mp5r82g4 295 4 for for IN cord-354029-mp5r82g4 295 5 the the DT cord-354029-mp5r82g4 295 6 lipid lipid NN cord-354029-mp5r82g4 295 7 transition transition NN cord-354029-mp5r82g4 295 8 state state NN cord-354029-mp5r82g4 295 9 during during IN cord-354029-mp5r82g4 295 10 membrane membrane NN cord-354029-mp5r82g4 295 11 fusion fusion NN cord-354029-mp5r82g4 295 12 is be VBZ cord-354029-mp5r82g4 295 13 the the DT cord-354029-mp5r82g4 295 14 stalk stalk NN cord-354029-mp5r82g4 295 15 model model NN cord-354029-mp5r82g4 295 16 . . . cord-354029-mp5r82g4 296 1 In in IN cord-354029-mp5r82g4 296 2 this this DT cord-354029-mp5r82g4 296 3 model model NN cord-354029-mp5r82g4 296 4 , , , cord-354029-mp5r82g4 296 5 two two CD cord-354029-mp5r82g4 296 6 opposing oppose VBG cord-354029-mp5r82g4 296 7 membranes membrane NNS cord-354029-mp5r82g4 296 8 bend bend VBP cord-354029-mp5r82g4 296 9 toward toward IN cord-354029-mp5r82g4 296 10 each each DT cord-354029-mp5r82g4 296 11 other other JJ cord-354029-mp5r82g4 296 12 , , , cord-354029-mp5r82g4 296 13 creating create VBG cord-354029-mp5r82g4 296 14 " " `` cord-354029-mp5r82g4 296 15 dimples dimple NNS cord-354029-mp5r82g4 296 16 " " '' cord-354029-mp5r82g4 296 17 ( ( -LRB- cord-354029-mp5r82g4 296 18 when when WRB cord-354029-mp5r82g4 296 19 viewed view VBN cord-354029-mp5r82g4 296 20 from from IN cord-354029-mp5r82g4 296 21 the the DT cord-354029-mp5r82g4 296 22 trans trans NNP cord-354029-mp5r82g4 296 23 surface surface NN cord-354029-mp5r82g4 296 24 ) ) -RRB- cord-354029-mp5r82g4 296 25 or or CC cord-354029-mp5r82g4 296 26 " " `` cord-354029-mp5r82g4 296 27 nipples nipple NNS cord-354029-mp5r82g4 296 28 " " '' cord-354029-mp5r82g4 296 29 ( ( -LRB- cord-354029-mp5r82g4 296 30 when when WRB cord-354029-mp5r82g4 296 31 viewed view VBN cord-354029-mp5r82g4 296 32 from from IN cord-354029-mp5r82g4 296 33 the the DT cord-354029-mp5r82g4 296 34 cis cis NNP cord-354029-mp5r82g4 296 35 surface surface NN cord-354029-mp5r82g4 296 36 ) ) -RRB- cord-354029-mp5r82g4 296 37 ( ( -LRB- cord-354029-mp5r82g4 296 38 Fig fig NN cord-354029-mp5r82g4 296 39 . . . cord-354029-mp5r82g4 297 1 3 3 LS cord-354029-mp5r82g4 297 2 , , , cord-354029-mp5r82g4 297 3 Step step NN cord-354029-mp5r82g4 297 4 4 4 CD cord-354029-mp5r82g4 297 5 ) ) -RRB- cord-354029-mp5r82g4 297 6 . . . cord-354029-mp5r82g4 298 1 Nipples nipple NNS cord-354029-mp5r82g4 298 2 continue continue VBP cord-354029-mp5r82g4 298 3 to to TO cord-354029-mp5r82g4 298 4 bend bend VB cord-354029-mp5r82g4 298 5 until until IN cord-354029-mp5r82g4 298 6 they -PRON- PRP cord-354029-mp5r82g4 298 7 meet meet VBP cord-354029-mp5r82g4 298 8 . . . cord-354029-mp5r82g4 299 1 The the DT cord-354029-mp5r82g4 299 2 two two CD cord-354029-mp5r82g4 299 3 cis cis NNP cord-354029-mp5r82g4 299 4 leaflets leaflet NNS cord-354029-mp5r82g4 299 5 then then RB cord-354029-mp5r82g4 299 6 merge merge VBP cord-354029-mp5r82g4 299 7 , , , cord-354029-mp5r82g4 299 8 creating create VBG cord-354029-mp5r82g4 299 9 a a DT cord-354029-mp5r82g4 299 10 lipid lipid NN cord-354029-mp5r82g4 299 11 stalk stalk NN cord-354029-mp5r82g4 299 12 ( ( -LRB- cord-354029-mp5r82g4 299 13 see see VB cord-354029-mp5r82g4 299 14 Fig Fig NNP cord-354029-mp5r82g4 299 15 . . NNP cord-354029-mp5r82g4 299 16 2 2 CD cord-354029-mp5r82g4 299 17 in in IN cord-354029-mp5r82g4 299 18 Kozlovsky Kozlovsky NNP cord-354029-mp5r82g4 299 19 and and CC cord-354029-mp5r82g4 299 20 Kozlov Kozlov NNP cord-354029-mp5r82g4 299 21 2002 2002 CD cord-354029-mp5r82g4 299 22 ) ) -RRB- cord-354029-mp5r82g4 300 1 that that DT cord-354029-mp5r82g4 300 2 proceeds proceed VBZ cord-354029-mp5r82g4 300 3 to to IN cord-354029-mp5r82g4 300 4 a a DT cord-354029-mp5r82g4 300 5 state state NN cord-354029-mp5r82g4 300 6 of of IN cord-354029-mp5r82g4 300 7 local local JJ cord-354029-mp5r82g4 300 8 hemifusion hemifusion NN cord-354029-mp5r82g4 301 1 ( ( -LRB- cord-354029-mp5r82g4 301 2 Fig Fig NNP cord-354029-mp5r82g4 301 3 . . . cord-354029-mp5r82g4 301 4 3 3 CD cord-354029-mp5r82g4 301 5 , , , cord-354029-mp5r82g4 301 6 Step step NN cord-354029-mp5r82g4 301 7 5 5 CD cord-354029-mp5r82g4 301 8 ) ) -RRB- cord-354029-mp5r82g4 301 9 . . . cord-354029-mp5r82g4 302 1 In in IN cord-354029-mp5r82g4 302 2 a a DT cord-354029-mp5r82g4 302 3 second second JJ cord-354029-mp5r82g4 302 4 step step NN cord-354029-mp5r82g4 302 5 , , , cord-354029-mp5r82g4 302 6 transient transient JJ cord-354029-mp5r82g4 302 7 fusion fusion NN cord-354029-mp5r82g4 302 8 pores pore NNS cord-354029-mp5r82g4 302 9 form form NN cord-354029-mp5r82g4 302 10 , , , cord-354029-mp5r82g4 302 11 which which WDT cord-354029-mp5r82g4 302 12 give give VBP cord-354029-mp5r82g4 302 13 rise rise NN cord-354029-mp5r82g4 302 14 to to IN cord-354029-mp5r82g4 302 15 stable stable JJ cord-354029-mp5r82g4 302 16 pores pore NNS cord-354029-mp5r82g4 302 17 ( ( -LRB- cord-354029-mp5r82g4 302 18 Fig fig NN cord-354029-mp5r82g4 302 19 . . . cord-354029-mp5r82g4 302 20 3 3 CD cord-354029-mp5r82g4 302 21 , , , cord-354029-mp5r82g4 302 22 Step Step NNP cord-354029-mp5r82g4 302 23 6 6 CD cord-354029-mp5r82g4 302 24 ) ) -RRB- cord-354029-mp5r82g4 302 25 . . . cord-354029-mp5r82g4 303 1 The the DT cord-354029-mp5r82g4 303 2 first first JJ cord-354029-mp5r82g4 303 3 direct direct JJ cord-354029-mp5r82g4 303 4 visualization visualization NN cord-354029-mp5r82g4 303 5 of of IN cord-354029-mp5r82g4 303 6 a a DT cord-354029-mp5r82g4 303 7 lipid lipid NN cord-354029-mp5r82g4 303 8 stalk stalk NN cord-354029-mp5r82g4 303 9 intermediate intermediate JJ cord-354029-mp5r82g4 303 10 was be VBD cord-354029-mp5r82g4 303 11 achieved achieve VBN cord-354029-mp5r82g4 303 12 by by IN cord-354029-mp5r82g4 303 13 electron electron NN cord-354029-mp5r82g4 303 14 diffraction diffraction NN cord-354029-mp5r82g4 303 15 studies study NNS cord-354029-mp5r82g4 303 16 of of IN cord-354029-mp5r82g4 303 17 the the DT cord-354029-mp5r82g4 303 18 effect effect NN cord-354029-mp5r82g4 303 19 of of IN cord-354029-mp5r82g4 303 20 sequential sequential JJ cord-354029-mp5r82g4 303 21 dehydration dehydration NN cord-354029-mp5r82g4 303 22 on on IN cord-354029-mp5r82g4 303 23 lipid lipid NN cord-354029-mp5r82g4 303 24 bilayers bilayer NNS cord-354029-mp5r82g4 303 25 composed compose VBN cord-354029-mp5r82g4 303 26 of of IN cord-354029-mp5r82g4 303 27 a a DT cord-354029-mp5r82g4 303 28 lipid lipid NN cord-354029-mp5r82g4 303 29 that that WDT cord-354029-mp5r82g4 303 30 has have VBZ cord-354029-mp5r82g4 303 31 negative negative JJ cord-354029-mp5r82g4 303 32 spontaneous spontaneous JJ cord-354029-mp5r82g4 303 33 curvature curvature NN cord-354029-mp5r82g4 303 34 ( ( -LRB- cord-354029-mp5r82g4 303 35 Yang Yang NNP cord-354029-mp5r82g4 303 36 and and CC cord-354029-mp5r82g4 303 37 Huang Huang NNP cord-354029-mp5r82g4 303 38 2002 2002 CD cord-354029-mp5r82g4 303 39 ) ) -RRB- cord-354029-mp5r82g4 303 40 . . . cord-354029-mp5r82g4 304 1 The the DT cord-354029-mp5r82g4 304 2 stalk stalk NN cord-354029-mp5r82g4 304 3 intermediate intermediate NN cord-354029-mp5r82g4 304 4 was be VBD cord-354029-mp5r82g4 304 5 stable stable JJ cord-354029-mp5r82g4 304 6 at at IN cord-354029-mp5r82g4 304 7 intermediate intermediate JJ cord-354029-mp5r82g4 304 8 relative relative JJ cord-354029-mp5r82g4 304 9 humidities humidity NNS cord-354029-mp5r82g4 304 10 . . . cord-354029-mp5r82g4 305 1 The the DT cord-354029-mp5r82g4 305 2 results result NNS cord-354029-mp5r82g4 305 3 suggested suggest VBD cord-354029-mp5r82g4 305 4 that that IN cord-354029-mp5r82g4 305 5 both both CC cord-354029-mp5r82g4 305 6 the the DT cord-354029-mp5r82g4 305 7 formation formation NN cord-354029-mp5r82g4 305 8 of of IN cord-354029-mp5r82g4 305 9 a a DT cord-354029-mp5r82g4 305 10 lipid lipid NN cord-354029-mp5r82g4 305 11 stalk stalk NN cord-354029-mp5r82g4 305 12 and and CC cord-354029-mp5r82g4 305 13 its -PRON- PRP$ cord-354029-mp5r82g4 305 14 transition transition NN cord-354029-mp5r82g4 305 15 to to IN cord-354029-mp5r82g4 305 16 a a DT cord-354029-mp5r82g4 305 17 conformation conformation NN cord-354029-mp5r82g4 305 18 that that WDT cord-354029-mp5r82g4 305 19 can can MD cord-354029-mp5r82g4 305 20 be be VB cord-354029-mp5r82g4 305 21 equated equate VBN cord-354029-mp5r82g4 305 22 with with IN cord-354029-mp5r82g4 305 23 pore pore NN cord-354029-mp5r82g4 305 24 formation formation NN cord-354029-mp5r82g4 305 25 require require VBP cord-354029-mp5r82g4 305 26 external external JJ cord-354029-mp5r82g4 305 27 forces force NNS cord-354029-mp5r82g4 305 28 . . . cord-354029-mp5r82g4 306 1 Cellular cellular JJ cord-354029-mp5r82g4 306 2 membranes membrane NNS cord-354029-mp5r82g4 306 3 do do VBP cord-354029-mp5r82g4 306 4 not not RB cord-354029-mp5r82g4 306 5 have have VB cord-354029-mp5r82g4 306 6 spontaneous spontaneous JJ cord-354029-mp5r82g4 306 7 negative negative JJ cord-354029-mp5r82g4 306 8 curvature curvature NN cord-354029-mp5r82g4 306 9 and and CC cord-354029-mp5r82g4 306 10 are be VBP cord-354029-mp5r82g4 306 11 highly highly RB cord-354029-mp5r82g4 306 12 hydrated hydrated JJ cord-354029-mp5r82g4 306 13 . . . cord-354029-mp5r82g4 307 1 Membrane membrane NN cord-354029-mp5r82g4 307 2 curvature curvature NN cord-354029-mp5r82g4 307 3 can can MD cord-354029-mp5r82g4 307 4 be be VB cord-354029-mp5r82g4 307 5 promoted promote VBN cord-354029-mp5r82g4 307 6 by by IN cord-354029-mp5r82g4 307 7 introducing introduce VBG cord-354029-mp5r82g4 307 8 defects defect NNS cord-354029-mp5r82g4 307 9 into into IN cord-354029-mp5r82g4 307 10 the the DT cord-354029-mp5r82g4 307 11 contacting contact VBG cord-354029-mp5r82g4 307 12 bilayers bilayer NNS cord-354029-mp5r82g4 307 13 . . . cord-354029-mp5r82g4 308 1 Thus thus RB cord-354029-mp5r82g4 308 2 roles role NNS cord-354029-mp5r82g4 308 3 for for IN cord-354029-mp5r82g4 308 4 the the DT cord-354029-mp5r82g4 308 5 fusion fusion NN cord-354029-mp5r82g4 308 6 protein protein NN cord-354029-mp5r82g4 308 7 include include VBP cord-354029-mp5r82g4 308 8 pulling pull VBG cord-354029-mp5r82g4 308 9 the the DT cord-354029-mp5r82g4 308 10 fusing fuse VBG cord-354029-mp5r82g4 308 11 bilayers bilayer NNS cord-354029-mp5r82g4 308 12 toward toward IN cord-354029-mp5r82g4 308 13 one one CD cord-354029-mp5r82g4 308 14 another another DT cord-354029-mp5r82g4 308 15 ( ( -LRB- cord-354029-mp5r82g4 308 16 dimpling dimple VBG cord-354029-mp5r82g4 308 17 ) ) -RRB- cord-354029-mp5r82g4 308 18 , , , cord-354029-mp5r82g4 308 19 dehydrating dehydrate VBG cord-354029-mp5r82g4 308 20 the the DT cord-354029-mp5r82g4 308 21 membranes membrane NNS cord-354029-mp5r82g4 308 22 , , , cord-354029-mp5r82g4 308 23 and and CC cord-354029-mp5r82g4 308 24 creating create VBG cord-354029-mp5r82g4 308 25 membrane membrane NN cord-354029-mp5r82g4 308 26 defects defect NNS cord-354029-mp5r82g4 308 27 that that WDT cord-354029-mp5r82g4 308 28 lower lower VBP cord-354029-mp5r82g4 308 29 the the DT cord-354029-mp5r82g4 308 30 energy energy NN cord-354029-mp5r82g4 308 31 barrier barrier NN cord-354029-mp5r82g4 308 32 for for IN cord-354029-mp5r82g4 308 33 stalk stalk NN cord-354029-mp5r82g4 308 34 and and CC cord-354029-mp5r82g4 308 35 pore pore NN cord-354029-mp5r82g4 308 36 formation formation NN cord-354029-mp5r82g4 308 37 . . . cord-354029-mp5r82g4 309 1 Two two CD cord-354029-mp5r82g4 309 2 intermediates intermediate NNS cord-354029-mp5r82g4 309 3 in in IN cord-354029-mp5r82g4 309 4 HIV HIV NNP cord-354029-mp5r82g4 309 5 fusion fusion NN cord-354029-mp5r82g4 309 6 have have VBP cord-354029-mp5r82g4 309 7 been be VBN cord-354029-mp5r82g4 309 8 trapped trap VBN cord-354029-mp5r82g4 309 9 : : : cord-354029-mp5r82g4 309 10 one one CD cord-354029-mp5r82g4 309 11 in in IN cord-354029-mp5r82g4 309 12 which which WDT cord-354029-mp5r82g4 309 13 the the DT cord-354029-mp5r82g4 309 14 two two CD cord-354029-mp5r82g4 309 15 membranes membrane NNS cord-354029-mp5r82g4 309 16 are be VBP cord-354029-mp5r82g4 309 17 joined join VBN cord-354029-mp5r82g4 309 18 by by IN cord-354029-mp5r82g4 309 19 activated activate VBN cord-354029-mp5r82g4 309 20 Envs Envs NNP cord-354029-mp5r82g4 309 21 , , , cord-354029-mp5r82g4 309 22 but but CC cord-354029-mp5r82g4 309 23 are be VBP cord-354029-mp5r82g4 309 24 not not RB cord-354029-mp5r82g4 309 25 yet yet RB cord-354029-mp5r82g4 309 26 fused fuse VBN cord-354029-mp5r82g4 309 27 ( ( -LRB- cord-354029-mp5r82g4 309 28 Melikyan Melikyan NNP cord-354029-mp5r82g4 309 29 et et NNP cord-354029-mp5r82g4 309 30 al al NNP cord-354029-mp5r82g4 309 31 . . NNP cord-354029-mp5r82g4 309 32 2000a 2000a CD cord-354029-mp5r82g4 309 33 ) ) -RRB- cord-354029-mp5r82g4 309 34 , , , cord-354029-mp5r82g4 309 35 and and CC cord-354029-mp5r82g4 309 36 one one CD cord-354029-mp5r82g4 309 37 in in IN cord-354029-mp5r82g4 309 38 which which WDT cord-354029-mp5r82g4 309 39 small small JJ cord-354029-mp5r82g4 309 40 , , , cord-354029-mp5r82g4 309 41 " " `` cord-354029-mp5r82g4 309 42 labile labile JJ cord-354029-mp5r82g4 309 43 " " '' cord-354029-mp5r82g4 309 44 pores pore NNS cord-354029-mp5r82g4 309 45 have have VBP cord-354029-mp5r82g4 309 46 formed form VBN cord-354029-mp5r82g4 309 47 that that WDT cord-354029-mp5r82g4 309 48 can can MD cord-354029-mp5r82g4 309 49 either either CC cord-354029-mp5r82g4 309 50 expand expand VB cord-354029-mp5r82g4 309 51 into into IN cord-354029-mp5r82g4 309 52 stable stable JJ cord-354029-mp5r82g4 309 53 , , , cord-354029-mp5r82g4 309 54 " " `` cord-354029-mp5r82g4 309 55 robust robust JJ cord-354029-mp5r82g4 309 56 " " '' cord-354029-mp5r82g4 309 57 pores pore NNS cord-354029-mp5r82g4 309 58 or or CC cord-354029-mp5r82g4 309 59 return return VB cord-354029-mp5r82g4 309 60 to to IN cord-354029-mp5r82g4 309 61 the the DT cord-354029-mp5r82g4 309 62 prefusion prefusion NN cord-354029-mp5r82g4 309 63 state state NN cord-354029-mp5r82g4 309 64 . . . cord-354029-mp5r82g4 310 1 These these DT cord-354029-mp5r82g4 310 2 observations observation NNS cord-354029-mp5r82g4 310 3 suggest suggest VBP cord-354029-mp5r82g4 310 4 a a DT cord-354029-mp5r82g4 310 5 role role NN cord-354029-mp5r82g4 310 6 for for IN cord-354029-mp5r82g4 310 7 the the DT cord-354029-mp5r82g4 310 8 fusion fusion NN cord-354029-mp5r82g4 310 9 protein protein NN cord-354029-mp5r82g4 310 10 in in IN cord-354029-mp5r82g4 310 11 formation formation NN cord-354029-mp5r82g4 310 12 and and CC cord-354029-mp5r82g4 310 13 stabilization stabilization NN cord-354029-mp5r82g4 310 14 of of IN cord-354029-mp5r82g4 310 15 both both CC cord-354029-mp5r82g4 310 16 the the DT cord-354029-mp5r82g4 310 17 fusion fusion NN cord-354029-mp5r82g4 310 18 stalk stalk NN cord-354029-mp5r82g4 310 19 and and CC cord-354029-mp5r82g4 310 20 the the DT cord-354029-mp5r82g4 310 21 fusion fusion NN cord-354029-mp5r82g4 310 22 pore pore NN cord-354029-mp5r82g4 310 23 . . . cord-354029-mp5r82g4 311 1 The the DT cord-354029-mp5r82g4 311 2 mechanism mechanism NN cord-354029-mp5r82g4 311 3 by by IN cord-354029-mp5r82g4 311 4 which which WDT cord-354029-mp5r82g4 311 5 a a DT cord-354029-mp5r82g4 311 6 small small JJ cord-354029-mp5r82g4 311 7 pore pore NN cord-354029-mp5r82g4 311 8 enlarges enlarge VBZ cord-354029-mp5r82g4 311 9 is be VBZ cord-354029-mp5r82g4 311 10 not not RB cord-354029-mp5r82g4 311 11 known know VBN cord-354029-mp5r82g4 311 12 . . . cord-354029-mp5r82g4 312 1 However however RB cord-354029-mp5r82g4 312 2 , , , cord-354029-mp5r82g4 312 3 several several JJ cord-354029-mp5r82g4 312 4 possibilities possibility NNS cord-354029-mp5r82g4 312 5 have have VBP cord-354029-mp5r82g4 312 6 been be VBN cord-354029-mp5r82g4 312 7 proposed propose VBN cord-354029-mp5r82g4 312 8 . . . cord-354029-mp5r82g4 313 1 One one CD cord-354029-mp5r82g4 313 2 is be VBZ cord-354029-mp5r82g4 313 3 that that IN cord-354029-mp5r82g4 313 4 the the DT cord-354029-mp5r82g4 313 5 initial initial JJ cord-354029-mp5r82g4 313 6 fusion fusion NN cord-354029-mp5r82g4 313 7 pore pore NN cord-354029-mp5r82g4 313 8 is be VBZ cord-354029-mp5r82g4 313 9 formed form VBN cord-354029-mp5r82g4 313 10 by by IN cord-354029-mp5r82g4 313 11 a a DT cord-354029-mp5r82g4 313 12 small small JJ cord-354029-mp5r82g4 313 13 number number NN cord-354029-mp5r82g4 313 14 of of IN cord-354029-mp5r82g4 313 15 activated activate VBN cord-354029-mp5r82g4 313 16 fusion fusion NN cord-354029-mp5r82g4 313 17 proteins protein NNS cord-354029-mp5r82g4 313 18 . . . cord-354029-mp5r82g4 314 1 Additional additional JJ cord-354029-mp5r82g4 314 2 activated activate VBN cord-354029-mp5r82g4 314 3 fusion fusion NN cord-354029-mp5r82g4 314 4 proteins protein NNS cord-354029-mp5r82g4 314 5 then then RB cord-354029-mp5r82g4 314 6 move move VBP cord-354029-mp5r82g4 314 7 into into IN cord-354029-mp5r82g4 314 8 the the DT cord-354029-mp5r82g4 314 9 fusion fusion NN cord-354029-mp5r82g4 314 10 site site NN cord-354029-mp5r82g4 314 11 to to TO cord-354029-mp5r82g4 314 12 buttress buttress VB cord-354029-mp5r82g4 314 13 and and CC cord-354029-mp5r82g4 314 14 stabilize stabilize VB cord-354029-mp5r82g4 314 15 the the DT cord-354029-mp5r82g4 314 16 pore pore NN cord-354029-mp5r82g4 314 17 , , , cord-354029-mp5r82g4 314 18 thereby thereby RB cord-354029-mp5r82g4 314 19 allowing allow VBG cord-354029-mp5r82g4 314 20 it -PRON- PRP cord-354029-mp5r82g4 314 21 to to TO cord-354029-mp5r82g4 314 22 expand expand VB cord-354029-mp5r82g4 314 23 ( ( -LRB- cord-354029-mp5r82g4 314 24 Kozlov Kozlov NNP cord-354029-mp5r82g4 314 25 and and CC cord-354029-mp5r82g4 314 26 Chernomordik Chernomordik NNP cord-354029-mp5r82g4 314 27 2002 2002 CD cord-354029-mp5r82g4 314 28 ) ) -RRB- cord-354029-mp5r82g4 314 29 . . . cord-354029-mp5r82g4 315 1 Another another DT cord-354029-mp5r82g4 315 2 possibility possibility NN cord-354029-mp5r82g4 315 3 is be VBZ cord-354029-mp5r82g4 315 4 that that IN cord-354029-mp5r82g4 315 5 multiple multiple JJ cord-354029-mp5r82g4 315 6 small small JJ cord-354029-mp5r82g4 315 7 fusion fusion NN cord-354029-mp5r82g4 315 8 pores pore NNS cord-354029-mp5r82g4 315 9 coalesce coalesce VBP cord-354029-mp5r82g4 315 10 to to TO cord-354029-mp5r82g4 315 11 form form VB cord-354029-mp5r82g4 315 12 larger large JJR cord-354029-mp5r82g4 315 13 ones one NNS cord-354029-mp5r82g4 315 14 . . . cord-354029-mp5r82g4 316 1 This this DT cord-354029-mp5r82g4 316 2 was be VBD cord-354029-mp5r82g4 316 3 supported support VBN cord-354029-mp5r82g4 316 4 by by IN cord-354029-mp5r82g4 316 5 EM EM NNP cord-354029-mp5r82g4 316 6 visualization visualization NN cord-354029-mp5r82g4 316 7 of of IN cord-354029-mp5r82g4 316 8 HA HA NNP cord-354029-mp5r82g4 316 9 - - HYPH cord-354029-mp5r82g4 316 10 mediated mediate VBN cord-354029-mp5r82g4 316 11 fusion fusion NN cord-354029-mp5r82g4 316 12 , , , cord-354029-mp5r82g4 316 13 in in IN cord-354029-mp5r82g4 316 14 which which WDT cord-354029-mp5r82g4 316 15 multiple multiple JJ cord-354029-mp5r82g4 316 16 dimples dimple NNS cord-354029-mp5r82g4 316 17 / / SYM cord-354029-mp5r82g4 316 18 nipples nipple NNS cord-354029-mp5r82g4 316 19 were be VBD cord-354029-mp5r82g4 316 20 arranged arrange VBN cord-354029-mp5r82g4 316 21 circularly circularly RB cord-354029-mp5r82g4 316 22 and and CC cord-354029-mp5r82g4 316 23 lipid lipid NN cord-354029-mp5r82g4 316 24 fragments fragment NNS cord-354029-mp5r82g4 316 25 were be VBD cord-354029-mp5r82g4 316 26 seen see VBN cord-354029-mp5r82g4 316 27 at at IN cord-354029-mp5r82g4 316 28 the the DT cord-354029-mp5r82g4 316 29 center center NN cord-354029-mp5r82g4 316 30 of of IN cord-354029-mp5r82g4 316 31 a a DT cord-354029-mp5r82g4 316 32 fusion fusion NN cord-354029-mp5r82g4 316 33 ring ring NN cord-354029-mp5r82g4 316 34 ( ( -LRB- cord-354029-mp5r82g4 316 35 Kanaseki Kanaseki NNP cord-354029-mp5r82g4 316 36 et et NNP cord-354029-mp5r82g4 316 37 al al NNP cord-354029-mp5r82g4 316 38 . . . cord-354029-mp5r82g4 316 39 1997 1997 CD cord-354029-mp5r82g4 316 40 ) ) -RRB- cord-354029-mp5r82g4 316 41 . . . cord-354029-mp5r82g4 317 1 As as IN cord-354029-mp5r82g4 317 2 discussed discuss VBN cord-354029-mp5r82g4 317 3 above above RB cord-354029-mp5r82g4 317 4 , , , cord-354029-mp5r82g4 317 5 roles role NNS cord-354029-mp5r82g4 317 6 for for IN cord-354029-mp5r82g4 317 7 the the DT cord-354029-mp5r82g4 317 8 fusion fusion NN cord-354029-mp5r82g4 317 9 protein protein NN cord-354029-mp5r82g4 317 10 in in IN cord-354029-mp5r82g4 317 11 the the DT cord-354029-mp5r82g4 317 12 fusion fusion NN cord-354029-mp5r82g4 317 13 cascade cascade NN cord-354029-mp5r82g4 317 14 ( ( -LRB- cord-354029-mp5r82g4 317 15 Fig Fig NNP cord-354029-mp5r82g4 317 16 . . . cord-354029-mp5r82g4 317 17 3 3 LS cord-354029-mp5r82g4 317 18 ) ) -RRB- cord-354029-mp5r82g4 317 19 include include VBP cord-354029-mp5r82g4 317 20 pulling pull VBG cord-354029-mp5r82g4 317 21 the the DT cord-354029-mp5r82g4 317 22 fusing fuse VBG cord-354029-mp5r82g4 317 23 bilayers bilayer NNS cord-354029-mp5r82g4 317 24 toward toward IN cord-354029-mp5r82g4 317 25 one one CD cord-354029-mp5r82g4 317 26 another another DT cord-354029-mp5r82g4 317 27 ( ( -LRB- cord-354029-mp5r82g4 317 28 dimpling dimple VBG cord-354029-mp5r82g4 317 29 ) ) -RRB- cord-354029-mp5r82g4 317 30 and and CC cord-354029-mp5r82g4 317 31 creating create VBG cord-354029-mp5r82g4 317 32 membrane membrane NN cord-354029-mp5r82g4 317 33 defects defect NNS cord-354029-mp5r82g4 317 34 that that WDT cord-354029-mp5r82g4 317 35 lower lower VBP cord-354029-mp5r82g4 317 36 the the DT cord-354029-mp5r82g4 317 37 energy energy NN cord-354029-mp5r82g4 317 38 barriers barrier NNS cord-354029-mp5r82g4 317 39 for for IN cord-354029-mp5r82g4 317 40 stalk stalk NN cord-354029-mp5r82g4 317 41 formation formation NN cord-354029-mp5r82g4 317 42 and and CC cord-354029-mp5r82g4 317 43 fusion fusion NN cord-354029-mp5r82g4 317 44 pore pore NN cord-354029-mp5r82g4 317 45 opening opening NN cord-354029-mp5r82g4 317 46 / / SYM cord-354029-mp5r82g4 317 47 enlargement enlargement NN cord-354029-mp5r82g4 317 48 . . . cord-354029-mp5r82g4 318 1 The the DT cord-354029-mp5r82g4 318 2 fusion fusion NN cord-354029-mp5r82g4 318 3 peptide peptide NN cord-354029-mp5r82g4 318 4 and and CC cord-354029-mp5r82g4 318 5 the the DT cord-354029-mp5r82g4 318 6 transmembrane transmembrane NN cord-354029-mp5r82g4 318 7 domain domain NN cord-354029-mp5r82g4 318 8 must must MD cord-354029-mp5r82g4 318 9 remain remain VB cord-354029-mp5r82g4 318 10 stably stably RB cord-354029-mp5r82g4 318 11 associated associate VBN cord-354029-mp5r82g4 318 12 with with IN cord-354029-mp5r82g4 318 13 the the DT cord-354029-mp5r82g4 318 14 target target NN cord-354029-mp5r82g4 318 15 and and CC cord-354029-mp5r82g4 318 16 viral viral JJ cord-354029-mp5r82g4 318 17 membranes membrane NNS cord-354029-mp5r82g4 318 18 , , , cord-354029-mp5r82g4 318 19 respectively respectively RB cord-354029-mp5r82g4 318 20 , , , cord-354029-mp5r82g4 318 21 for for IN cord-354029-mp5r82g4 318 22 fusion fusion NN cord-354029-mp5r82g4 318 23 to to TO cord-354029-mp5r82g4 318 24 occur occur VB cord-354029-mp5r82g4 318 25 . . . cord-354029-mp5r82g4 319 1 Once once IN cord-354029-mp5r82g4 319 2 the the DT cord-354029-mp5r82g4 319 3 fusion fusion NN cord-354029-mp5r82g4 319 4 peptide peptide NN cord-354029-mp5r82g4 319 5 is be VBZ cord-354029-mp5r82g4 319 6 stably stably RB cord-354029-mp5r82g4 319 7 associated associate VBN cord-354029-mp5r82g4 319 8 with with IN cord-354029-mp5r82g4 319 9 the the DT cord-354029-mp5r82g4 319 10 target target NN cord-354029-mp5r82g4 319 11 bilayer bilayer NN cord-354029-mp5r82g4 319 12 ( ( -LRB- cord-354029-mp5r82g4 319 13 Fig Fig NNP cord-354029-mp5r82g4 319 14 . . . cord-354029-mp5r82g4 319 15 3 3 CD cord-354029-mp5r82g4 319 16 , , , cord-354029-mp5r82g4 319 17 Step step NN cord-354029-mp5r82g4 319 18 2 2 CD cord-354029-mp5r82g4 319 19 ) ) -RRB- cord-354029-mp5r82g4 319 20 , , , cord-354029-mp5r82g4 319 21 we -PRON- PRP cord-354029-mp5r82g4 319 22 envision envision VBP cord-354029-mp5r82g4 319 23 that that IN cord-354029-mp5r82g4 319 24 rearrangements rearrangement NNS cord-354029-mp5r82g4 319 25 in in IN cord-354029-mp5r82g4 319 26 the the DT cord-354029-mp5r82g4 319 27 fusion fusion NN cord-354029-mp5r82g4 319 28 protein protein NN cord-354029-mp5r82g4 319 29 ectodomain ectodomain NNP cord-354029-mp5r82g4 319 30 that that WDT cord-354029-mp5r82g4 319 31 bring bring VBP cord-354029-mp5r82g4 319 32 the the DT cord-354029-mp5r82g4 319 33 fusion fusion NN cord-354029-mp5r82g4 319 34 peptide peptide NN cord-354029-mp5r82g4 319 35 and and CC cord-354029-mp5r82g4 319 36 transmembrane transmembrane NN cord-354029-mp5r82g4 319 37 domains domain NNS cord-354029-mp5r82g4 319 38 close close VBP cord-354029-mp5r82g4 319 39 together together RB cord-354029-mp5r82g4 320 1 ( ( -LRB- cord-354029-mp5r82g4 320 2 Fig Fig NNP cord-354029-mp5r82g4 320 3 . . . cord-354029-mp5r82g4 320 4 3 3 CD cord-354029-mp5r82g4 320 5 , , , cord-354029-mp5r82g4 320 6 Step step NN cord-354029-mp5r82g4 320 7 4 4 CD cord-354029-mp5r82g4 320 8 ) ) -RRB- cord-354029-mp5r82g4 320 9 result result VBP cord-354029-mp5r82g4 320 10 in in IN cord-354029-mp5r82g4 320 11 dimpling dimpling NN cord-354029-mp5r82g4 320 12 of of IN cord-354029-mp5r82g4 320 13 membranes membrane NNS cord-354029-mp5r82g4 320 14 toward toward IN cord-354029-mp5r82g4 320 15 one one CD cord-354029-mp5r82g4 320 16 another another DT cord-354029-mp5r82g4 320 17 . . . cord-354029-mp5r82g4 321 1 In in IN cord-354029-mp5r82g4 321 2 addition addition NN cord-354029-mp5r82g4 321 3 to to IN cord-354029-mp5r82g4 321 4 serving serve VBG cord-354029-mp5r82g4 321 5 as as IN cord-354029-mp5r82g4 321 6 critical critical JJ cord-354029-mp5r82g4 321 7 membrane membrane NN cord-354029-mp5r82g4 321 8 anchors anchor NNS cord-354029-mp5r82g4 321 9 , , , cord-354029-mp5r82g4 321 10 the the DT cord-354029-mp5r82g4 321 11 fusion fusion NN cord-354029-mp5r82g4 321 12 peptide peptide NN cord-354029-mp5r82g4 321 13 and and CC cord-354029-mp5r82g4 321 14 the the DT cord-354029-mp5r82g4 321 15 transmembrane transmembrane NN cord-354029-mp5r82g4 321 16 domain domain NN cord-354029-mp5r82g4 321 17 likely likely RB cord-354029-mp5r82g4 321 18 create create VBP cord-354029-mp5r82g4 321 19 membrane membrane NN cord-354029-mp5r82g4 321 20 defects defect NNS cord-354029-mp5r82g4 321 21 that that WDT cord-354029-mp5r82g4 321 22 facilitate facilitate VBP cord-354029-mp5r82g4 321 23 the the DT cord-354029-mp5r82g4 321 24 next next JJ cord-354029-mp5r82g4 321 25 stages stage NNS cord-354029-mp5r82g4 321 26 of of IN cord-354029-mp5r82g4 321 27 fusion fusion NN cord-354029-mp5r82g4 321 28 . . . cord-354029-mp5r82g4 322 1 Here here RB cord-354029-mp5r82g4 322 2 , , , cord-354029-mp5r82g4 322 3 we -PRON- PRP cord-354029-mp5r82g4 322 4 review review VBP cord-354029-mp5r82g4 322 5 information information NN cord-354029-mp5r82g4 322 6 about about IN cord-354029-mp5r82g4 322 7 the the DT cord-354029-mp5r82g4 322 8 structure structure NN cord-354029-mp5r82g4 322 9 and and CC cord-354029-mp5r82g4 322 10 function function NN cord-354029-mp5r82g4 322 11 of of IN cord-354029-mp5r82g4 322 12 the the DT cord-354029-mp5r82g4 322 13 fusion fusion NN cord-354029-mp5r82g4 322 14 peptide peptide NN cord-354029-mp5r82g4 322 15 and and CC cord-354029-mp5r82g4 322 16 the the DT cord-354029-mp5r82g4 322 17 transmembrane transmembrane NN cord-354029-mp5r82g4 322 18 domain domain NN cord-354029-mp5r82g4 322 19 during during IN cord-354029-mp5r82g4 322 20 fusion fusion NN cord-354029-mp5r82g4 322 21 . . . cord-354029-mp5r82g4 323 1 We -PRON- PRP cord-354029-mp5r82g4 323 2 also also RB cord-354029-mp5r82g4 323 3 review review VBP cord-354029-mp5r82g4 323 4 evidence evidence NN cord-354029-mp5r82g4 323 5 that that IN cord-354029-mp5r82g4 323 6 juxtamembrane juxtamembrane NNP cord-354029-mp5r82g4 323 7 sequences sequences NNP cord-354029-mp5r82g4 323 8 , , , cord-354029-mp5r82g4 323 9 on on IN cord-354029-mp5r82g4 323 10 both both DT cord-354029-mp5r82g4 323 11 sides side NNS cord-354029-mp5r82g4 323 12 of of IN cord-354029-mp5r82g4 323 13 the the DT cord-354029-mp5r82g4 323 14 transmembrane transmembrane NN cord-354029-mp5r82g4 323 15 domain domain NN cord-354029-mp5r82g4 323 16 , , , cord-354029-mp5r82g4 323 17 participate participate VB cord-354029-mp5r82g4 323 18 in in IN cord-354029-mp5r82g4 323 19 fusion fusion NN cord-354029-mp5r82g4 323 20 . . . cord-354029-mp5r82g4 324 1 Fusion fusion NN cord-354029-mp5r82g4 324 2 peptides peptide NNS cord-354029-mp5r82g4 324 3 are be VBP cord-354029-mp5r82g4 324 4 relatively relatively RB cord-354029-mp5r82g4 324 5 apolar apolar JJ cord-354029-mp5r82g4 324 6 sequences sequence NNS cord-354029-mp5r82g4 324 7 that that WDT cord-354029-mp5r82g4 324 8 interact interact VBP cord-354029-mp5r82g4 324 9 with with IN cord-354029-mp5r82g4 324 10 membranes membrane NNS cord-354029-mp5r82g4 324 11 and and CC cord-354029-mp5r82g4 324 12 are be VBP cord-354029-mp5r82g4 324 13 central central JJ cord-354029-mp5r82g4 324 14 to to IN cord-354029-mp5r82g4 324 15 viral viral JJ cord-354029-mp5r82g4 324 16 fusion fusion NN cord-354029-mp5r82g4 324 17 reactions reaction NNS cord-354029-mp5r82g4 324 18 ( ( -LRB- cord-354029-mp5r82g4 324 19 Martin Martin NNP cord-354029-mp5r82g4 324 20 and and CC cord-354029-mp5r82g4 324 21 Ruysschaert Ruysschaert NNP cord-354029-mp5r82g4 324 22 2000 2000 CD cord-354029-mp5r82g4 324 23 ; ; : cord-354029-mp5r82g4 325 1 Martin Martin NNP cord-354029-mp5r82g4 325 2 et et NNP cord-354029-mp5r82g4 325 3 al al NNP cord-354029-mp5r82g4 325 4 . . . cord-354029-mp5r82g4 326 1 1999 1999 CD cord-354029-mp5r82g4 326 2 ; ; : cord-354029-mp5r82g4 326 3 Skehel Skehel NNP cord-354029-mp5r82g4 326 4 et et NNP cord-354029-mp5r82g4 326 5 al al NNP cord-354029-mp5r82g4 326 6 . . . cord-354029-mp5r82g4 327 1 2001 2001 CD cord-354029-mp5r82g4 327 2 ; ; : cord-354029-mp5r82g4 327 3 White White NNP cord-354029-mp5r82g4 327 4 1990 1990 CD cord-354029-mp5r82g4 327 5 ) ) -RRB- cord-354029-mp5r82g4 327 6 . . . cord-354029-mp5r82g4 328 1 They -PRON- PRP cord-354029-mp5r82g4 328 2 have have VBP cord-354029-mp5r82g4 328 3 been be VBN cord-354029-mp5r82g4 328 4 Fig Fig NNP cord-354029-mp5r82g4 328 5 . . . cord-354029-mp5r82g4 329 1 5A 5a NN cord-354029-mp5r82g4 329 2 , , , cord-354029-mp5r82g4 329 3 B. B. NNP cord-354029-mp5r82g4 329 4 Characteristics Characteristics NNP cord-354029-mp5r82g4 329 5 of of IN cord-354029-mp5r82g4 329 6 viral viral JJ cord-354029-mp5r82g4 329 7 fusion fusion NN cord-354029-mp5r82g4 329 8 peptides peptide NNS cord-354029-mp5r82g4 329 9 . . . cord-354029-mp5r82g4 330 1 A a DT cord-354029-mp5r82g4 330 2 Selected select VBN cord-354029-mp5r82g4 330 3 viral viral JJ cord-354029-mp5r82g4 330 4 fusion fusion NN cord-354029-mp5r82g4 330 5 peptide peptide NN cord-354029-mp5r82g4 330 6 sequences sequence NNS cord-354029-mp5r82g4 330 7 . . . cord-354029-mp5r82g4 331 1 N n CD cord-354029-mp5r82g4 331 2 - - HYPH cord-354029-mp5r82g4 331 3 terminal terminal NN cord-354029-mp5r82g4 331 4 ) ) -RRB- cord-354029-mp5r82g4 331 5 and and CC cord-354029-mp5r82g4 331 6 internal internal JJ cord-354029-mp5r82g4 331 7 fusion fusion NN cord-354029-mp5r82g4 331 8 peptide peptide NN cord-354029-mp5r82g4 331 9 sequences sequence NNS cord-354029-mp5r82g4 331 10 are be VBP cord-354029-mp5r82g4 331 11 aligned align VBN cord-354029-mp5r82g4 331 12 according accord VBG cord-354029-mp5r82g4 331 13 to to IN cord-354029-mp5r82g4 331 14 their -PRON- PRP$ cord-354029-mp5r82g4 331 15 first first JJ cord-354029-mp5r82g4 331 16 noncharged noncharged JJ cord-354029-mp5r82g4 331 17 residue residue NN cord-354029-mp5r82g4 331 18 . . . cord-354029-mp5r82g4 332 1 B B NNP cord-354029-mp5r82g4 332 2 Model Model NNP cord-354029-mp5r82g4 332 3 of of IN cord-354029-mp5r82g4 332 4 HA HA NNP cord-354029-mp5r82g4 332 5 fusion fusion NN cord-354029-mp5r82g4 332 6 peptide peptide NN cord-354029-mp5r82g4 332 7 structure structure NN cord-354029-mp5r82g4 332 8 in in IN cord-354029-mp5r82g4 332 9 target target NN cord-354029-mp5r82g4 332 10 membrane membrane NN cord-354029-mp5r82g4 332 11 at at IN cord-354029-mp5r82g4 332 12 pH pH NNP cord-354029-mp5r82g4 332 13 5 5 CD cord-354029-mp5r82g4 332 14 ( ( -LRB- cord-354029-mp5r82g4 332 15 adapted adapt VBN cord-354029-mp5r82g4 332 16 from from IN cord-354029-mp5r82g4 332 17 Tamm Tamm NNP cord-354029-mp5r82g4 332 18 et et NNP cord-354029-mp5r82g4 332 19 al al NNP cord-354029-mp5r82g4 332 20 . . . cord-354029-mp5r82g4 332 21 2002 2002 CD cord-354029-mp5r82g4 332 22 ) ) -RRB- cord-354029-mp5r82g4 332 23 . . . cord-354029-mp5r82g4 333 1 The the DT cord-354029-mp5r82g4 333 2 fusion fusion NN cord-354029-mp5r82g4 333 3 peptide peptide NN cord-354029-mp5r82g4 333 4 ( ( -LRB- cord-354029-mp5r82g4 333 5 red red NNP cord-354029-mp5r82g4 333 6 ) ) -RRB- cord-354029-mp5r82g4 333 7 resides reside VBZ cord-354029-mp5r82g4 333 8 in in IN cord-354029-mp5r82g4 333 9 the the DT cord-354029-mp5r82g4 333 10 target target NN cord-354029-mp5r82g4 333 11 membrane membrane NN cord-354029-mp5r82g4 333 12 in in IN cord-354029-mp5r82g4 333 13 a a DT cord-354029-mp5r82g4 333 14 kinked kinked JJ cord-354029-mp5r82g4 333 15 structure structure NN cord-354029-mp5r82g4 333 16 composed compose VBN cord-354029-mp5r82g4 333 17 of of IN cord-354029-mp5r82g4 333 18 two two CD cord-354029-mp5r82g4 333 19 a a DT cord-354029-mp5r82g4 333 20 - - : cord-354029-mp5r82g4 333 21 helices helix NNS cord-354029-mp5r82g4 333 22 , , , cord-354029-mp5r82g4 333 23 each each DT cord-354029-mp5r82g4 333 24 penetrating penetrate VBG cord-354029-mp5r82g4 333 25 the the DT cord-354029-mp5r82g4 333 26 outer outer JJ cord-354029-mp5r82g4 333 27 leaflet leaflet NN cord-354029-mp5r82g4 333 28 . . . cord-354029-mp5r82g4 334 1 The the DT cord-354029-mp5r82g4 334 2 glycine glycine NN cord-354029-mp5r82g4 334 3 ridge ridge NN cord-354029-mp5r82g4 334 4 is be VBZ cord-354029-mp5r82g4 334 5 depicted depict VBN cord-354029-mp5r82g4 334 6 by by IN cord-354029-mp5r82g4 334 7 a a DT cord-354029-mp5r82g4 334 8 yellow yellow JJ cord-354029-mp5r82g4 334 9 box box NN cord-354029-mp5r82g4 334 10 , , , cord-354029-mp5r82g4 334 11 the the DT cord-354029-mp5r82g4 334 12 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 334 13 interior interior JJ cord-354029-mp5r82g4 334 14 face face NN cord-354029-mp5r82g4 334 15 by by IN cord-354029-mp5r82g4 334 16 cyan cyan NN cord-354029-mp5r82g4 334 17 ovals oval NNS cord-354029-mp5r82g4 334 18 , , , cord-354029-mp5r82g4 334 19 and and CC cord-354029-mp5r82g4 334 20 the the DT cord-354029-mp5r82g4 334 21 surface surface NN cord-354029-mp5r82g4 334 22 charged charge VBN cord-354029-mp5r82g4 334 23 residues residue NNS cord-354029-mp5r82g4 334 24 by by IN cord-354029-mp5r82g4 334 25 blue blue JJ cord-354029-mp5r82g4 334 26 squares square NNS cord-354029-mp5r82g4 334 27 . . . cord-354029-mp5r82g4 334 28 " " `` cord-354029-mp5r82g4 334 29 C C NNP cord-354029-mp5r82g4 334 30 " " '' cord-354029-mp5r82g4 334 31 denotes denote VBZ cord-354029-mp5r82g4 334 32 the the DT cord-354029-mp5r82g4 334 33 direction direction NN cord-354029-mp5r82g4 334 34 of of IN cord-354029-mp5r82g4 334 35 the the DT cord-354029-mp5r82g4 334 36 HA2 HA2 NNP cord-354029-mp5r82g4 334 37 ectodomain ectodomain NNP cord-354029-mp5r82g4 334 38 classified classify VBD cord-354029-mp5r82g4 334 39 as as IN cord-354029-mp5r82g4 334 40 N n CD cord-354029-mp5r82g4 334 41 - - HYPH cord-354029-mp5r82g4 334 42 terminal terminal JJ cord-354029-mp5r82g4 334 43 or or CC cord-354029-mp5r82g4 334 44 internal internal JJ cord-354029-mp5r82g4 334 45 depending depending NN cord-354029-mp5r82g4 334 46 on on IN cord-354029-mp5r82g4 334 47 their -PRON- PRP$ cord-354029-mp5r82g4 334 48 location location NN cord-354029-mp5r82g4 334 49 within within IN cord-354029-mp5r82g4 334 50 the the DT cord-354029-mp5r82g4 334 51 fusion fusion NN cord-354029-mp5r82g4 334 52 subunit subunit NN cord-354029-mp5r82g4 334 53 ( ( -LRB- cord-354029-mp5r82g4 334 54 Table table NN cord-354029-mp5r82g4 334 55 1 1 CD cord-354029-mp5r82g4 334 56 ) ) -RRB- cord-354029-mp5r82g4 334 57 . . . cord-354029-mp5r82g4 335 1 Although although IN cord-354029-mp5r82g4 335 2 fusion fusion NN cord-354029-mp5r82g4 335 3 peptides peptide NNS cord-354029-mp5r82g4 335 4 are be VBP cord-354029-mp5r82g4 335 5 highly highly RB cord-354029-mp5r82g4 335 6 conserved conserve VBN cord-354029-mp5r82g4 335 7 within within IN cord-354029-mp5r82g4 335 8 each each DT cord-354029-mp5r82g4 335 9 virus virus NN cord-354029-mp5r82g4 335 10 family family NN cord-354029-mp5r82g4 335 11 , , , cord-354029-mp5r82g4 335 12 there there EX cord-354029-mp5r82g4 335 13 is be VBZ cord-354029-mp5r82g4 335 14 little little JJ cord-354029-mp5r82g4 335 15 sequence sequence NN cord-354029-mp5r82g4 335 16 similarity similarity NN cord-354029-mp5r82g4 335 17 between between IN cord-354029-mp5r82g4 335 18 fusion fusion NN cord-354029-mp5r82g4 335 19 peptides peptide NNS cord-354029-mp5r82g4 335 20 of of IN cord-354029-mp5r82g4 335 21 different different JJ cord-354029-mp5r82g4 335 22 families family NNS cord-354029-mp5r82g4 335 23 ( ( -LRB- cord-354029-mp5r82g4 335 24 Fig Fig NNP cord-354029-mp5r82g4 335 25 . . . cord-354029-mp5r82g4 335 26 5A 5a CD cord-354029-mp5r82g4 335 27 ) ) -RRB- cord-354029-mp5r82g4 335 28 . . . cord-354029-mp5r82g4 336 1 Generally generally RB cord-354029-mp5r82g4 336 2 , , , cord-354029-mp5r82g4 336 3 however however RB cord-354029-mp5r82g4 336 4 , , , cord-354029-mp5r82g4 336 5 fusion fusion NN cord-354029-mp5r82g4 336 6 peptides peptide NNS cord-354029-mp5r82g4 336 7 contain contain VBP cord-354029-mp5r82g4 336 8 a a DT cord-354029-mp5r82g4 336 9 high high JJ cord-354029-mp5r82g4 336 10 percentage percentage NN cord-354029-mp5r82g4 336 11 of of IN cord-354029-mp5r82g4 336 12 glycines glycine NNS cord-354029-mp5r82g4 336 13 and/or and/or CC cord-354029-mp5r82g4 336 14 alanines alanine NNS cord-354029-mp5r82g4 336 15 , , , cord-354029-mp5r82g4 336 16 as as RB cord-354029-mp5r82g4 336 17 well well RB cord-354029-mp5r82g4 336 18 as as IN cord-354029-mp5r82g4 336 19 several several JJ cord-354029-mp5r82g4 336 20 critical critical JJ cord-354029-mp5r82g4 336 21 bulky bulky JJ cord-354029-mp5r82g4 336 22 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 336 23 residues residue NNS cord-354029-mp5r82g4 336 24 ( ( -LRB- cord-354029-mp5r82g4 336 25 Martin Martin NNP cord-354029-mp5r82g4 336 26 and and CC cord-354029-mp5r82g4 336 27 Ruysschaert Ruysschaert NNP cord-354029-mp5r82g4 336 28 2000 2000 CD cord-354029-mp5r82g4 336 29 ; ; : cord-354029-mp5r82g4 336 30 Martin Martin NNP cord-354029-mp5r82g4 336 31 et et NNP cord-354029-mp5r82g4 336 32 al al NNP cord-354029-mp5r82g4 336 33 . . . cord-354029-mp5r82g4 336 34 1999 1999 CD cord-354029-mp5r82g4 336 35 ; ; : cord-354029-mp5r82g4 336 36 Skehel Skehel NNP cord-354029-mp5r82g4 336 37 et et NNP cord-354029-mp5r82g4 336 38 al al NNP cord-354029-mp5r82g4 336 39 . . NNP cord-354029-mp5r82g4 336 40 2001 2001 CD cord-354029-mp5r82g4 336 41 ; ; . cord-354029-mp5r82g4 337 1 Tamm Tamm NNP cord-354029-mp5r82g4 337 2 and and CC cord-354029-mp5r82g4 337 3 Han Han NNP cord-354029-mp5r82g4 337 4 2000 2000 CD cord-354029-mp5r82g4 337 5 ; ; : cord-354029-mp5r82g4 337 6 Tamm Tamm NNP cord-354029-mp5r82g4 337 7 et et NNP cord-354029-mp5r82g4 337 8 al al NNP cord-354029-mp5r82g4 337 9 . . . cord-354029-mp5r82g4 337 10 2002 2002 CD cord-354029-mp5r82g4 337 11 ) ) -RRB- cord-354029-mp5r82g4 337 12 . . . cord-354029-mp5r82g4 338 1 A a DT cord-354029-mp5r82g4 338 2 significant significant JJ cord-354029-mp5r82g4 338 3 body body NN cord-354029-mp5r82g4 338 4 of of IN cord-354029-mp5r82g4 338 5 work work NN cord-354029-mp5r82g4 338 6 has have VBZ cord-354029-mp5r82g4 338 7 emerged emerge VBN cord-354029-mp5r82g4 338 8 on on IN cord-354029-mp5r82g4 338 9 the the DT cord-354029-mp5r82g4 338 10 structure structure NN cord-354029-mp5r82g4 338 11 and and CC cord-354029-mp5r82g4 338 12 function function NN cord-354029-mp5r82g4 338 13 of of IN cord-354029-mp5r82g4 338 14 synthetic synthetic JJ cord-354029-mp5r82g4 338 15 fusion fusion NN cord-354029-mp5r82g4 338 16 peptides peptide NNS cord-354029-mp5r82g4 338 17 ( ( -LRB- cord-354029-mp5r82g4 338 18 Martin Martin NNP cord-354029-mp5r82g4 338 19 and and CC cord-354029-mp5r82g4 338 20 Ruysschaert Ruysschaert NNP cord-354029-mp5r82g4 338 21 2000 2000 CD cord-354029-mp5r82g4 338 22 ; ; : cord-354029-mp5r82g4 338 23 Martin Martin NNP cord-354029-mp5r82g4 338 24 et et NNP cord-354029-mp5r82g4 338 25 al al NNP cord-354029-mp5r82g4 338 26 . . . cord-354029-mp5r82g4 338 27 1999 1999 CD cord-354029-mp5r82g4 338 28 ; ; : cord-354029-mp5r82g4 338 29 Skehel Skehel NNP cord-354029-mp5r82g4 338 30 et et NNP cord-354029-mp5r82g4 338 31 al al NNP cord-354029-mp5r82g4 338 32 . . . cord-354029-mp5r82g4 339 1 2001 2001 CD cord-354029-mp5r82g4 339 2 ; ; : cord-354029-mp5r82g4 339 3 Tamm Tamm NNP cord-354029-mp5r82g4 339 4 and and CC cord-354029-mp5r82g4 339 5 Han Han NNP cord-354029-mp5r82g4 339 6 2000 2000 CD cord-354029-mp5r82g4 339 7 ; ; : cord-354029-mp5r82g4 339 8 Tamm Tamm NNP cord-354029-mp5r82g4 339 9 et et NNP cord-354029-mp5r82g4 339 10 al al NNP cord-354029-mp5r82g4 339 11 . . . cord-354029-mp5r82g4 339 12 2002 2002 CD cord-354029-mp5r82g4 339 13 ) ) -RRB- cord-354029-mp5r82g4 339 14 . . . cord-354029-mp5r82g4 340 1 Synthetic synthetic JJ cord-354029-mp5r82g4 340 2 fusion fusion NN cord-354029-mp5r82g4 340 3 peptides peptide NNS cord-354029-mp5r82g4 340 4 are be VBP cord-354029-mp5r82g4 340 5 disordered disordered JJ cord-354029-mp5r82g4 340 6 in in IN cord-354029-mp5r82g4 340 7 solution solution NN cord-354029-mp5r82g4 340 8 but but CC cord-354029-mp5r82g4 340 9 ordered order VBN cord-354029-mp5r82g4 340 10 ( ( -LRB- cord-354029-mp5r82g4 340 11 a a DT cord-354029-mp5r82g4 340 12 - - HYPH cord-354029-mp5r82g4 340 13 helix helix NN cord-354029-mp5r82g4 340 14 and/or and/or CC cord-354029-mp5r82g4 340 15 b b NN cord-354029-mp5r82g4 340 16 - - HYPH cord-354029-mp5r82g4 340 17 sheet sheet NN cord-354029-mp5r82g4 340 18 ) ) -RRB- cord-354029-mp5r82g4 340 19 when when WRB cord-354029-mp5r82g4 340 20 they -PRON- PRP cord-354029-mp5r82g4 340 21 associate associate VBP cord-354029-mp5r82g4 340 22 with with IN cord-354029-mp5r82g4 340 23 membranes membrane NNS cord-354029-mp5r82g4 340 24 . . . cord-354029-mp5r82g4 341 1 The the DT cord-354029-mp5r82g4 341 2 N n CD cord-354029-mp5r82g4 341 3 - - HYPH cord-354029-mp5r82g4 341 4 terminal terminal NN cord-354029-mp5r82g4 341 5 fusion fusion NN cord-354029-mp5r82g4 341 6 peptides peptide NNS cord-354029-mp5r82g4 341 7 that that WDT cord-354029-mp5r82g4 341 8 have have VBP cord-354029-mp5r82g4 341 9 been be VBN cord-354029-mp5r82g4 341 10 studied study VBN cord-354029-mp5r82g4 341 11 insert insert NN cord-354029-mp5r82g4 341 12 into into IN cord-354029-mp5r82g4 341 13 membranes membrane NNS cord-354029-mp5r82g4 341 14 at at IN cord-354029-mp5r82g4 341 15 oblique oblique JJ cord-354029-mp5r82g4 341 16 angles angle NNS cord-354029-mp5r82g4 341 17 and and CC cord-354029-mp5r82g4 341 18 do do VBP cord-354029-mp5r82g4 341 19 not not RB cord-354029-mp5r82g4 341 20 penetrate penetrate VB cord-354029-mp5r82g4 341 21 the the DT cord-354029-mp5r82g4 341 22 inner inner JJ cord-354029-mp5r82g4 341 23 leaflet leaflet NN cord-354029-mp5r82g4 341 24 of of IN cord-354029-mp5r82g4 341 25 the the DT cord-354029-mp5r82g4 341 26 membrane membrane NN cord-354029-mp5r82g4 341 27 . . . cord-354029-mp5r82g4 342 1 In in IN cord-354029-mp5r82g4 342 2 general general JJ cord-354029-mp5r82g4 342 3 , , , cord-354029-mp5r82g4 342 4 mutations mutation NNS cord-354029-mp5r82g4 342 5 that that WDT cord-354029-mp5r82g4 342 6 abrogate abrogate VBP cord-354029-mp5r82g4 342 7 fusion fusion NN cord-354029-mp5r82g4 342 8 reduce reduce VB cord-354029-mp5r82g4 342 9 the the DT cord-354029-mp5r82g4 342 10 ability ability NN cord-354029-mp5r82g4 342 11 of of IN cord-354029-mp5r82g4 342 12 synthetic synthetic JJ cord-354029-mp5r82g4 342 13 fusion fusion NN cord-354029-mp5r82g4 342 14 peptides peptide NNS cord-354029-mp5r82g4 342 15 to to TO cord-354029-mp5r82g4 342 16 insert insert VB cord-354029-mp5r82g4 342 17 at at IN cord-354029-mp5r82g4 342 18 oblique oblique JJ cord-354029-mp5r82g4 342 19 angles angle NNS cord-354029-mp5r82g4 342 20 and and CC cord-354029-mp5r82g4 342 21 to to TO cord-354029-mp5r82g4 342 22 disrupt disrupt VB cord-354029-mp5r82g4 342 23 membranes membrane NNS cord-354029-mp5r82g4 342 24 ( ( -LRB- cord-354029-mp5r82g4 342 25 Martin Martin NNP cord-354029-mp5r82g4 342 26 et et NNP cord-354029-mp5r82g4 342 27 al al NNP cord-354029-mp5r82g4 342 28 . . . cord-354029-mp5r82g4 342 29 1999 1999 CD cord-354029-mp5r82g4 342 30 ) ) -RRB- cord-354029-mp5r82g4 342 31 . . . cord-354029-mp5r82g4 343 1 Contradictory contradictory JJ cord-354029-mp5r82g4 343 2 conclusions conclusion NNS cord-354029-mp5r82g4 343 3 on on IN cord-354029-mp5r82g4 343 4 the the DT cord-354029-mp5r82g4 343 5 precise precise JJ cord-354029-mp5r82g4 343 6 structure structure NN cord-354029-mp5r82g4 343 7 of of IN cord-354029-mp5r82g4 343 8 synthetic synthetic JJ cord-354029-mp5r82g4 343 9 fusion fusion NN cord-354029-mp5r82g4 343 10 peptides peptide NNS cord-354029-mp5r82g4 343 11 in in IN cord-354029-mp5r82g4 343 12 membranes membrane NNS cord-354029-mp5r82g4 343 13 likely likely RB cord-354029-mp5r82g4 343 14 stem stem VBP cord-354029-mp5r82g4 343 15 from from IN cord-354029-mp5r82g4 343 16 the the DT cord-354029-mp5r82g4 343 17 general general JJ cord-354029-mp5r82g4 343 18 low low JJ cord-354029-mp5r82g4 343 19 solubility solubility NN cord-354029-mp5r82g4 343 20 of of IN cord-354029-mp5r82g4 343 21 the the DT cord-354029-mp5r82g4 343 22 peptides peptide NNS cord-354029-mp5r82g4 343 23 in in IN cord-354029-mp5r82g4 343 24 aqueous aqueous JJ cord-354029-mp5r82g4 343 25 solution solution NN cord-354029-mp5r82g4 343 26 and and CC cord-354029-mp5r82g4 343 27 the the DT cord-354029-mp5r82g4 343 28 different different JJ cord-354029-mp5r82g4 343 29 experimental experimental JJ cord-354029-mp5r82g4 343 30 methods method NNS cord-354029-mp5r82g4 343 31 employed employ VBN cord-354029-mp5r82g4 343 32 ( ( -LRB- cord-354029-mp5r82g4 343 33 Tamm Tamm NNP cord-354029-mp5r82g4 343 34 et et NNP cord-354029-mp5r82g4 343 35 al al NNP cord-354029-mp5r82g4 343 36 . . . cord-354029-mp5r82g4 343 37 2002 2002 CD cord-354029-mp5r82g4 343 38 ) ) -RRB- cord-354029-mp5r82g4 343 39 . . . cord-354029-mp5r82g4 344 1 To to TO cord-354029-mp5r82g4 344 2 circumvent circumvent VB cord-354029-mp5r82g4 344 3 solubility solubility NN cord-354029-mp5r82g4 344 4 problems problem NNS cord-354029-mp5r82g4 344 5 , , , cord-354029-mp5r82g4 344 6 a a DT cord-354029-mp5r82g4 344 7 polar polar JJ cord-354029-mp5r82g4 344 8 sequence sequence NN cord-354029-mp5r82g4 344 9 was be VBD cord-354029-mp5r82g4 344 10 added add VBN cord-354029-mp5r82g4 344 11 to to IN cord-354029-mp5r82g4 344 12 the the DT cord-354029-mp5r82g4 344 13 C C NNP cord-354029-mp5r82g4 344 14 - - HYPH cord-354029-mp5r82g4 344 15 terminal terminal JJ cord-354029-mp5r82g4 344 16 end end NN cord-354029-mp5r82g4 344 17 of of IN cord-354029-mp5r82g4 344 18 the the DT cord-354029-mp5r82g4 344 19 influenza influenza NN cord-354029-mp5r82g4 344 20 HA HA NNP cord-354029-mp5r82g4 344 21 fusion fusion NN cord-354029-mp5r82g4 344 22 peptide peptide NN cord-354029-mp5r82g4 344 23 , , , cord-354029-mp5r82g4 344 24 rendering render VBG cord-354029-mp5r82g4 344 25 it -PRON- PRP cord-354029-mp5r82g4 344 26 soluble soluble JJ cord-354029-mp5r82g4 344 27 in in IN cord-354029-mp5r82g4 344 28 both both CC cord-354029-mp5r82g4 344 29 aqueous aqueous JJ cord-354029-mp5r82g4 344 30 and and CC cord-354029-mp5r82g4 344 31 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 344 32 environments environment NNS cord-354029-mp5r82g4 345 1 ( ( -LRB- cord-354029-mp5r82g4 345 2 Han Han NNP cord-354029-mp5r82g4 345 3 et et NNP cord-354029-mp5r82g4 345 4 al al NNP cord-354029-mp5r82g4 345 5 . . NNP cord-354029-mp5r82g4 345 6 2001 2001 CD cord-354029-mp5r82g4 345 7 ) ) -RRB- cord-354029-mp5r82g4 345 8 . . . cord-354029-mp5r82g4 346 1 At at IN cord-354029-mp5r82g4 346 2 pH pH NNP cord-354029-mp5r82g4 346 3 5 5 CD cord-354029-mp5r82g4 346 4 , , , cord-354029-mp5r82g4 346 5 the the DT cord-354029-mp5r82g4 346 6 HA HA NNP cord-354029-mp5r82g4 346 7 fusion fusion NN cord-354029-mp5r82g4 346 8 peptide peptide NN cord-354029-mp5r82g4 346 9 consists consist VBZ cord-354029-mp5r82g4 346 10 of of IN cord-354029-mp5r82g4 346 11 an an DT cord-354029-mp5r82g4 346 12 N n CD cord-354029-mp5r82g4 346 13 - - HYPH cord-354029-mp5r82g4 346 14 terminal terminal JJ cord-354029-mp5r82g4 346 15 helix helix NN cord-354029-mp5r82g4 346 16 , , , cord-354029-mp5r82g4 346 17 a a DT cord-354029-mp5r82g4 346 18 kink kink NN cord-354029-mp5r82g4 346 19 , , , cord-354029-mp5r82g4 346 20 and and CC cord-354029-mp5r82g4 346 21 a a DT cord-354029-mp5r82g4 346 22 short short JJ cord-354029-mp5r82g4 346 23 C c NN cord-354029-mp5r82g4 346 24 - - HYPH cord-354029-mp5r82g4 346 25 terminal terminal NN cord-354029-mp5r82g4 346 26 helix helix NN cord-354029-mp5r82g4 346 27 ( ( -LRB- cord-354029-mp5r82g4 346 28 Fig Fig NNP cord-354029-mp5r82g4 346 29 . . . cord-354029-mp5r82g4 346 30 5B 5b CD cord-354029-mp5r82g4 346 31 ) ) -RRB- cord-354029-mp5r82g4 346 32 . . . cord-354029-mp5r82g4 347 1 Both both CC cord-354029-mp5r82g4 347 2 the the DT cord-354029-mp5r82g4 347 3 N N NNP cord-354029-mp5r82g4 347 4 - - HYPH cord-354029-mp5r82g4 347 5 and and CC cord-354029-mp5r82g4 347 6 C c NN cord-354029-mp5r82g4 347 7 - - HYPH cord-354029-mp5r82g4 347 8 terminal terminal NN cord-354029-mp5r82g4 347 9 helices helix NNS cord-354029-mp5r82g4 347 10 penetrate penetrate VBP cord-354029-mp5r82g4 347 11 the the DT cord-354029-mp5r82g4 347 12 outer outer JJ cord-354029-mp5r82g4 347 13 leaflet leaflet NN cord-354029-mp5r82g4 347 14 of of IN cord-354029-mp5r82g4 347 15 the the DT cord-354029-mp5r82g4 347 16 target target NN cord-354029-mp5r82g4 347 17 bilayer bilayer NN cord-354029-mp5r82g4 347 18 . . . cord-354029-mp5r82g4 348 1 The the DT cord-354029-mp5r82g4 348 2 kink kink NN cord-354029-mp5r82g4 348 3 remains remain VBZ cord-354029-mp5r82g4 348 4 at at IN cord-354029-mp5r82g4 348 5 the the DT cord-354029-mp5r82g4 348 6 phospholipid phospholipid NN cord-354029-mp5r82g4 348 7 surface surface NN cord-354029-mp5r82g4 348 8 ; ; : cord-354029-mp5r82g4 348 9 the the DT cord-354029-mp5r82g4 348 10 interior interior JJ cord-354029-mp5r82g4 348 11 ( ( -LRB- cord-354029-mp5r82g4 348 12 lipid lipid NN cord-354029-mp5r82g4 348 13 - - HYPH cord-354029-mp5r82g4 348 14 facing face VBG cord-354029-mp5r82g4 348 15 surface surface NN cord-354029-mp5r82g4 348 16 ) ) -RRB- cord-354029-mp5r82g4 348 17 of of IN cord-354029-mp5r82g4 348 18 the the DT cord-354029-mp5r82g4 348 19 kink kink NN cord-354029-mp5r82g4 348 20 is be VBZ cord-354029-mp5r82g4 348 21 lined line VBN cord-354029-mp5r82g4 348 22 with with IN cord-354029-mp5r82g4 348 23 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 348 24 residues residue NNS cord-354029-mp5r82g4 348 25 . . . cord-354029-mp5r82g4 349 1 The the DT cord-354029-mp5r82g4 349 2 conserved conserved JJ cord-354029-mp5r82g4 349 3 glycines glycine NNS cord-354029-mp5r82g4 349 4 form form VBP cord-354029-mp5r82g4 349 5 a a DT cord-354029-mp5r82g4 349 6 ridge ridge NN cord-354029-mp5r82g4 349 7 along along IN cord-354029-mp5r82g4 349 8 the the DT cord-354029-mp5r82g4 349 9 outer outer JJ cord-354029-mp5r82g4 349 10 face face NN cord-354029-mp5r82g4 349 11 of of IN cord-354029-mp5r82g4 349 12 the the DT cord-354029-mp5r82g4 349 13 N n CD cord-354029-mp5r82g4 349 14 - - HYPH cord-354029-mp5r82g4 349 15 terminal terminal JJ cord-354029-mp5r82g4 349 16 helix helix NN cord-354029-mp5r82g4 349 17 . . . cord-354029-mp5r82g4 350 1 Three three CD cord-354029-mp5r82g4 350 2 charged charge VBN cord-354029-mp5r82g4 350 3 residues residue NNS cord-354029-mp5r82g4 350 4 are be VBP cord-354029-mp5r82g4 350 5 also also RB cord-354029-mp5r82g4 350 6 found find VBN cord-354029-mp5r82g4 350 7 on on IN cord-354029-mp5r82g4 350 8 the the DT cord-354029-mp5r82g4 350 9 outer outer JJ cord-354029-mp5r82g4 350 10 face face NN cord-354029-mp5r82g4 350 11 ( ( -LRB- cord-354029-mp5r82g4 350 12 Fig Fig NNP cord-354029-mp5r82g4 350 13 . . . cord-354029-mp5r82g4 350 14 5B 5b CD cord-354029-mp5r82g4 350 15 ) ) -RRB- cord-354029-mp5r82g4 350 16 . . . cord-354029-mp5r82g4 351 1 An an DT cord-354029-mp5r82g4 351 2 HA HA NNP cord-354029-mp5r82g4 351 3 in in IN cord-354029-mp5r82g4 351 4 which which WDT cord-354029-mp5r82g4 351 5 the the DT cord-354029-mp5r82g4 351 6 conserved conserve VBN cord-354029-mp5r82g4 351 7 glycine glycine NN cord-354029-mp5r82g4 351 8 at at IN cord-354029-mp5r82g4 351 9 the the DT cord-354029-mp5r82g4 351 10 beginning beginning NN cord-354029-mp5r82g4 351 11 of of IN cord-354029-mp5r82g4 351 12 the the DT cord-354029-mp5r82g4 351 13 fusion fusion NN cord-354029-mp5r82g4 351 14 peptide peptide NN cord-354029-mp5r82g4 351 15 ( ( -LRB- cord-354029-mp5r82g4 351 16 Gly1 Gly1 NNP cord-354029-mp5r82g4 351 17 ) ) -RRB- cord-354029-mp5r82g4 351 18 has have VBZ cord-354029-mp5r82g4 351 19 been be VBN cord-354029-mp5r82g4 351 20 changed change VBN cord-354029-mp5r82g4 351 21 to to IN cord-354029-mp5r82g4 351 22 valine valine NN cord-354029-mp5r82g4 351 23 can can MD cord-354029-mp5r82g4 351 24 not not RB cord-354029-mp5r82g4 351 25 mediate mediate VB cord-354029-mp5r82g4 351 26 fusion fusion NN cord-354029-mp5r82g4 351 27 . . . cord-354029-mp5r82g4 352 1 If if IN cord-354029-mp5r82g4 352 2 Gly1 Gly1 NNP cord-354029-mp5r82g4 352 3 is be VBZ cord-354029-mp5r82g4 352 4 changed change VBN cord-354029-mp5r82g4 352 5 to to IN cord-354029-mp5r82g4 352 6 serine serine NN cord-354029-mp5r82g4 352 7 , , , cord-354029-mp5r82g4 352 8 HA HA NNP cord-354029-mp5r82g4 352 9 mediates mediate VBZ cord-354029-mp5r82g4 352 10 only only RB cord-354029-mp5r82g4 352 11 hemifusion hemifusion NN cord-354029-mp5r82g4 352 12 or or CC cord-354029-mp5r82g4 352 13 only only JJ cord-354029-mp5r82g4 352 14 forms form VBZ cord-354029-mp5r82g4 352 15 small small JJ cord-354029-mp5r82g4 352 16 nonexpanding nonexpanding NN cord-354029-mp5r82g4 352 17 fusion fusion NN cord-354029-mp5r82g4 352 18 pores pore NNS cord-354029-mp5r82g4 353 1 ( ( -LRB- cord-354029-mp5r82g4 353 2 Qiao Qiao NNP cord-354029-mp5r82g4 353 3 et et FW cord-354029-mp5r82g4 353 4 al al NNP cord-354029-mp5r82g4 353 5 . . . cord-354029-mp5r82g4 354 1 1999 1999 CD cord-354029-mp5r82g4 354 2 ; ; : cord-354029-mp5r82g4 354 3 Skehel Skehel NNP cord-354029-mp5r82g4 354 4 et et NNP cord-354029-mp5r82g4 354 5 al al NNP cord-354029-mp5r82g4 354 6 . . NNP cord-354029-mp5r82g4 354 7 2001 2001 CD cord-354029-mp5r82g4 354 8 ) ) -RRB- cord-354029-mp5r82g4 354 9 . . . cord-354029-mp5r82g4 355 1 Interestingly interestingly RB cord-354029-mp5r82g4 355 2 , , , cord-354029-mp5r82g4 355 3 these these DT cord-354029-mp5r82g4 355 4 mutant mutant JJ cord-354029-mp5r82g4 355 5 fusion fusion NN cord-354029-mp5r82g4 355 6 peptides peptide NNS cord-354029-mp5r82g4 355 7 have have VBP cord-354029-mp5r82g4 355 8 membrane membrane NN cord-354029-mp5r82g4 355 9 - - HYPH cord-354029-mp5r82g4 355 10 associated associate VBN cord-354029-mp5r82g4 355 11 structures structure NNS cord-354029-mp5r82g4 355 12 and and CC cord-354029-mp5r82g4 355 13 orientations orientation NNS cord-354029-mp5r82g4 355 14 significantly significantly RB cord-354029-mp5r82g4 355 15 different different JJ cord-354029-mp5r82g4 355 16 from from IN cord-354029-mp5r82g4 355 17 those those DT cord-354029-mp5r82g4 355 18 of of IN cord-354029-mp5r82g4 355 19 the the DT cord-354029-mp5r82g4 355 20 wild wild JJ cord-354029-mp5r82g4 355 21 - - HYPH cord-354029-mp5r82g4 355 22 type type NN cord-354029-mp5r82g4 355 23 fusion fusion NN cord-354029-mp5r82g4 355 24 peptide peptide NN cord-354029-mp5r82g4 355 25 ( ( -LRB- cord-354029-mp5r82g4 355 26 Li Li NNP cord-354029-mp5r82g4 355 27 et et NNP cord-354029-mp5r82g4 355 28 al al NNP cord-354029-mp5r82g4 355 29 . . NNP cord-354029-mp5r82g4 355 30 2003 2003 CD cord-354029-mp5r82g4 355 31 ) ) -RRB- cord-354029-mp5r82g4 355 32 . . . cord-354029-mp5r82g4 356 1 Simulations simulation NNS cord-354029-mp5r82g4 356 2 suggested suggest VBD cord-354029-mp5r82g4 356 3 similar similar JJ cord-354029-mp5r82g4 356 4 membrane membrane NN cord-354029-mp5r82g4 356 5 penetrating penetrate VBG cord-354029-mp5r82g4 356 6 orientations orientation NNS cord-354029-mp5r82g4 356 7 for for IN cord-354029-mp5r82g4 356 8 the the DT cord-354029-mp5r82g4 356 9 HIV HIV NNP cord-354029-mp5r82g4 356 10 fusion fusion NN cord-354029-mp5r82g4 356 11 peptide peptide NN cord-354029-mp5r82g4 356 12 and and CC cord-354029-mp5r82g4 356 13 two two CD cord-354029-mp5r82g4 356 14 fusion fusion NN cord-354029-mp5r82g4 356 15 - - HYPH cord-354029-mp5r82g4 356 16 defective defective JJ cord-354029-mp5r82g4 356 17 mutants mutant NNS cord-354029-mp5r82g4 356 18 ( ( -LRB- cord-354029-mp5r82g4 356 19 Kamath Kamath NNP cord-354029-mp5r82g4 356 20 and and CC cord-354029-mp5r82g4 356 21 Wong Wong NNP cord-354029-mp5r82g4 356 22 2002 2002 CD cord-354029-mp5r82g4 356 23 ) ) -RRB- cord-354029-mp5r82g4 356 24 . . . cord-354029-mp5r82g4 357 1 In in IN cord-354029-mp5r82g4 357 2 addition addition NN cord-354029-mp5r82g4 357 3 to to IN cord-354029-mp5r82g4 357 4 a a DT cord-354029-mp5r82g4 357 5 significant significant JJ cord-354029-mp5r82g4 357 6 number number NN cord-354029-mp5r82g4 357 7 of of IN cord-354029-mp5r82g4 357 8 apolar apolar JJ cord-354029-mp5r82g4 357 9 residues residue NNS cord-354029-mp5r82g4 357 10 , , , cord-354029-mp5r82g4 357 11 many many JJ cord-354029-mp5r82g4 357 12 internal internal JJ cord-354029-mp5r82g4 357 13 fusion fusion NN cord-354029-mp5r82g4 357 14 peptides peptide NNS cord-354029-mp5r82g4 357 15 contain contain VBP cord-354029-mp5r82g4 357 16 a a DT cord-354029-mp5r82g4 357 17 conserved conserve VBN cord-354029-mp5r82g4 357 18 proline proline NN cord-354029-mp5r82g4 357 19 at at IN cord-354029-mp5r82g4 357 20 or or CC cord-354029-mp5r82g4 357 21 near near IN cord-354029-mp5r82g4 357 22 their -PRON- PRP$ cord-354029-mp5r82g4 357 23 centers center NNS cord-354029-mp5r82g4 357 24 ( ( -LRB- cord-354029-mp5r82g4 357 25 Fig Fig NNP cord-354029-mp5r82g4 357 26 . . . cord-354029-mp5r82g4 357 27 5A 5a CD cord-354029-mp5r82g4 357 28 ) ) -RRB- cord-354029-mp5r82g4 357 29 . . . cord-354029-mp5r82g4 358 1 Mutagenesis Mutagenesis NNP cord-354029-mp5r82g4 358 2 of of IN cord-354029-mp5r82g4 358 3 this this DT cord-354029-mp5r82g4 358 4 proline proline NN cord-354029-mp5r82g4 358 5 in in IN cord-354029-mp5r82g4 358 6 the the DT cord-354029-mp5r82g4 358 7 avian avian JJ cord-354029-mp5r82g4 358 8 sarcoma sarcoma NN cord-354029-mp5r82g4 358 9 / / SYM cord-354029-mp5r82g4 358 10 leukosis leukosis NN cord-354029-mp5r82g4 358 11 virus virus NN cord-354029-mp5r82g4 358 12 ( ( -LRB- cord-354029-mp5r82g4 358 13 ASLV ASLV NNP cord-354029-mp5r82g4 358 14 ) ) -RRB- cord-354029-mp5r82g4 359 1 EnvA EnvA NNP cord-354029-mp5r82g4 359 2 fusion fusion NN cord-354029-mp5r82g4 359 3 peptide peptide NN cord-354029-mp5r82g4 359 4 suggested suggest VBD cord-354029-mp5r82g4 359 5 that that IN cord-354029-mp5r82g4 359 6 it -PRON- PRP cord-354029-mp5r82g4 359 7 stabilizes stabilize VBZ cord-354029-mp5r82g4 359 8 a a DT cord-354029-mp5r82g4 359 9 b b NN cord-354029-mp5r82g4 359 10 - - HYPH cord-354029-mp5r82g4 359 11 turn turn NN cord-354029-mp5r82g4 359 12 . . . cord-354029-mp5r82g4 360 1 This this DT cord-354029-mp5r82g4 360 2 , , , cord-354029-mp5r82g4 360 3 coupled couple VBN cord-354029-mp5r82g4 360 4 with with IN cord-354029-mp5r82g4 360 5 the the DT cord-354029-mp5r82g4 360 6 observation observation NN cord-354029-mp5r82g4 360 7 that that IN cord-354029-mp5r82g4 360 8 mutating mutate VBG cord-354029-mp5r82g4 360 9 two two CD cord-354029-mp5r82g4 360 10 cysteines cysteine NNS cord-354029-mp5r82g4 360 11 that that WDT cord-354029-mp5r82g4 360 12 flank flank VBP cord-354029-mp5r82g4 360 13 the the DT cord-354029-mp5r82g4 360 14 fusion fusion NN cord-354029-mp5r82g4 360 15 peptide peptide NN cord-354029-mp5r82g4 360 16 abolishes abolish VBZ cord-354029-mp5r82g4 360 17 fusion fusion NN cord-354029-mp5r82g4 360 18 activity activity NN cord-354029-mp5r82g4 360 19 , , , cord-354029-mp5r82g4 360 20 suggested suggest VBD cord-354029-mp5r82g4 360 21 that that IN cord-354029-mp5r82g4 360 22 the the DT cord-354029-mp5r82g4 360 23 internal internal JJ cord-354029-mp5r82g4 360 24 EnvA EnvA NNP cord-354029-mp5r82g4 360 25 fusion fusion NN cord-354029-mp5r82g4 360 26 peptide peptide NN cord-354029-mp5r82g4 360 27 exists exist VBZ cord-354029-mp5r82g4 360 28 as as IN cord-354029-mp5r82g4 360 29 a a DT cord-354029-mp5r82g4 360 30 looped looped JJ cord-354029-mp5r82g4 360 31 structure structure NN cord-354029-mp5r82g4 360 32 stabilized stabilize VBN cord-354029-mp5r82g4 360 33 by by IN cord-354029-mp5r82g4 360 34 a a DT cord-354029-mp5r82g4 360 35 disulfide disulfide JJ cord-354029-mp5r82g4 360 36 bond bond NN cord-354029-mp5r82g4 360 37 . . . cord-354029-mp5r82g4 361 1 The the DT cord-354029-mp5r82g4 361 2 ability ability NN cord-354029-mp5r82g4 361 3 of of IN cord-354029-mp5r82g4 361 4 the the DT cord-354029-mp5r82g4 361 5 Ebola Ebola NNP cord-354029-mp5r82g4 361 6 virus virus NN cord-354029-mp5r82g4 361 7 fusion fusion NN cord-354029-mp5r82g4 361 8 protein protein NN cord-354029-mp5r82g4 361 9 , , , cord-354029-mp5r82g4 361 10 which which WDT cord-354029-mp5r82g4 361 11 also also RB cord-354029-mp5r82g4 361 12 contains contain VBZ cord-354029-mp5r82g4 361 13 an an DT cord-354029-mp5r82g4 361 14 internal internal JJ cord-354029-mp5r82g4 361 15 fusion fusion NN cord-354029-mp5r82g4 361 16 peptide peptide NN cord-354029-mp5r82g4 361 17 , , , cord-354029-mp5r82g4 361 18 to to TO cord-354029-mp5r82g4 361 19 support support VB cord-354029-mp5r82g4 361 20 infection infection NN cord-354029-mp5r82g4 361 21 was be VBD cord-354029-mp5r82g4 361 22 similarly similarly RB cord-354029-mp5r82g4 361 23 inhibited inhibit VBN cord-354029-mp5r82g4 361 24 when when WRB cord-354029-mp5r82g4 361 25 its -PRON- PRP$ cord-354029-mp5r82g4 361 26 central central JJ cord-354029-mp5r82g4 361 27 proline proline NN cord-354029-mp5r82g4 361 28 and and CC cord-354029-mp5r82g4 361 29 flanking flanking JJ cord-354029-mp5r82g4 361 30 cysteines cysteine NNS cord-354029-mp5r82g4 361 31 were be VBD cord-354029-mp5r82g4 361 32 mutated mutate VBN cord-354029-mp5r82g4 361 33 ( ( -LRB- cord-354029-mp5r82g4 361 34 Ito Ito NNP cord-354029-mp5r82g4 361 35 et et FW cord-354029-mp5r82g4 361 36 al al NNP cord-354029-mp5r82g4 361 37 . . . cord-354029-mp5r82g4 362 1 1999 1999 CD cord-354029-mp5r82g4 362 2 ; ; : cord-354029-mp5r82g4 362 3 Jeffers Jeffers NNP cord-354029-mp5r82g4 362 4 et et NNP cord-354029-mp5r82g4 362 5 al al NNP cord-354029-mp5r82g4 362 6 . . . cord-354029-mp5r82g4 362 7 2002 2002 CD cord-354029-mp5r82g4 362 8 ) ) -RRB- cord-354029-mp5r82g4 362 9 . . . cord-354029-mp5r82g4 363 1 A a DT cord-354029-mp5r82g4 363 2 similar similar JJ cord-354029-mp5r82g4 363 3 mutation mutation NN cord-354029-mp5r82g4 363 4 of of IN cord-354029-mp5r82g4 363 5 a a DT cord-354029-mp5r82g4 363 6 proline proline NN cord-354029-mp5r82g4 363 7 within within IN cord-354029-mp5r82g4 363 8 the the DT cord-354029-mp5r82g4 363 9 predicted predict VBN cord-354029-mp5r82g4 363 10 turn turn NN cord-354029-mp5r82g4 363 11 segment segment NN cord-354029-mp5r82g4 363 12 of of IN cord-354029-mp5r82g4 363 13 the the DT cord-354029-mp5r82g4 363 14 candidate candidate NN cord-354029-mp5r82g4 363 15 fusion fusion NN cord-354029-mp5r82g4 363 16 peptide peptide NN cord-354029-mp5r82g4 363 17 of of IN cord-354029-mp5r82g4 363 18 VSV VSV NNP cord-354029-mp5r82g4 363 19 G G NNP cord-354029-mp5r82g4 363 20 also also RB cord-354029-mp5r82g4 363 21 significantly significantly RB cord-354029-mp5r82g4 363 22 decreased decrease VBD cord-354029-mp5r82g4 363 23 fusion fusion NN cord-354029-mp5r82g4 363 24 and and CC cord-354029-mp5r82g4 363 25 abolished abolish VBN cord-354029-mp5r82g4 363 26 infectivity infectivity NN cord-354029-mp5r82g4 363 27 ( ( -LRB- cord-354029-mp5r82g4 363 28 Fredericksen Fredericksen NNP cord-354029-mp5r82g4 363 29 and and CC cord-354029-mp5r82g4 363 30 Whitt Whitt NNP cord-354029-mp5r82g4 363 31 1995 1995 CD cord-354029-mp5r82g4 363 32 ) ) -RRB- cord-354029-mp5r82g4 363 33 . . . cord-354029-mp5r82g4 364 1 The the DT cord-354029-mp5r82g4 364 2 idea idea NN cord-354029-mp5r82g4 364 3 of of IN cord-354029-mp5r82g4 364 4 loop loop NN cord-354029-mp5r82g4 364 5 structures structure NNS cord-354029-mp5r82g4 364 6 for for IN cord-354029-mp5r82g4 364 7 internal internal JJ cord-354029-mp5r82g4 364 8 fusion fusion NN cord-354029-mp5r82g4 364 9 peptides peptide NNS cord-354029-mp5r82g4 364 10 is be VBZ cord-354029-mp5r82g4 364 11 further further RB cord-354029-mp5r82g4 364 12 supported support VBN cord-354029-mp5r82g4 364 13 by by IN cord-354029-mp5r82g4 364 14 the the DT cord-354029-mp5r82g4 364 15 known know VBN cord-354029-mp5r82g4 364 16 looped looped JJ cord-354029-mp5r82g4 364 17 structure structure NN cord-354029-mp5r82g4 364 18 of of IN cord-354029-mp5r82g4 364 19 the the DT cord-354029-mp5r82g4 364 20 TBE TBE NNP cord-354029-mp5r82g4 364 21 E e NN cord-354029-mp5r82g4 364 22 and and CC cord-354029-mp5r82g4 364 23 SFV SFV NNP cord-354029-mp5r82g4 364 24 EI EI NNP cord-354029-mp5r82g4 364 25 fusion fusion NN cord-354029-mp5r82g4 364 26 peptides peptide NNS cord-354029-mp5r82g4 364 27 ( ( -LRB- cord-354029-mp5r82g4 364 28 Rey Rey NNP cord-354029-mp5r82g4 364 29 et et NNP cord-354029-mp5r82g4 364 30 al al NNP cord-354029-mp5r82g4 364 31 . . NNP cord-354029-mp5r82g4 364 32 1995 1995 CD cord-354029-mp5r82g4 364 33 ; ; : cord-354029-mp5r82g4 364 34 Lescar Lescar NNP cord-354029-mp5r82g4 364 35 et et NNP cord-354029-mp5r82g4 364 36 al al NNP cord-354029-mp5r82g4 364 37 . . NNP cord-354029-mp5r82g4 364 38 2001 2001 CD cord-354029-mp5r82g4 364 39 ) ) -RRB- cord-354029-mp5r82g4 364 40 . . . cord-354029-mp5r82g4 365 1 In in IN cord-354029-mp5r82g4 365 2 some some DT cord-354029-mp5r82g4 365 3 cases case NNS cord-354029-mp5r82g4 365 4 , , , cord-354029-mp5r82g4 365 5 two two CD cord-354029-mp5r82g4 365 6 or or CC cord-354029-mp5r82g4 365 7 more more JJR cord-354029-mp5r82g4 365 8 noncontiguous noncontiguous JJ cord-354029-mp5r82g4 365 9 sequence sequence NN cord-354029-mp5r82g4 365 10 loops loop NNS cord-354029-mp5r82g4 365 11 may may MD cord-354029-mp5r82g4 365 12 function function VB cord-354029-mp5r82g4 365 13 as as IN cord-354029-mp5r82g4 365 14 a a DT cord-354029-mp5r82g4 365 15 collective collective JJ cord-354029-mp5r82g4 365 16 fusion fusion NN cord-354029-mp5r82g4 365 17 peptide peptide NN cord-354029-mp5r82g4 365 18 ( ( -LRB- cord-354029-mp5r82g4 365 19 Gaudin Gaudin NNP cord-354029-mp5r82g4 365 20 et et NNP cord-354029-mp5r82g4 365 21 al al NNP cord-354029-mp5r82g4 365 22 . . . cord-354029-mp5r82g4 366 1 1999a 1999a CD cord-354029-mp5r82g4 366 2 ; ; : cord-354029-mp5r82g4 366 3 Li Li NNP cord-354029-mp5r82g4 366 4 et et NNP cord-354029-mp5r82g4 366 5 al al NNP cord-354029-mp5r82g4 366 6 . . . cord-354029-mp5r82g4 366 7 1993 1993 CD cord-354029-mp5r82g4 366 8 ) ) -RRB- cord-354029-mp5r82g4 366 9 . . . cord-354029-mp5r82g4 367 1 Like like IN cord-354029-mp5r82g4 367 2 N n CD cord-354029-mp5r82g4 367 3 - - HYPH cord-354029-mp5r82g4 367 4 terminal terminal NN cord-354029-mp5r82g4 367 5 fusion fusion NN cord-354029-mp5r82g4 367 6 peptides peptide NNS cord-354029-mp5r82g4 367 7 , , , cord-354029-mp5r82g4 367 8 internal internal JJ cord-354029-mp5r82g4 367 9 fusion fusion NN cord-354029-mp5r82g4 367 10 peptides peptide NNS cord-354029-mp5r82g4 367 11 contain contain VBP cord-354029-mp5r82g4 367 12 a a DT cord-354029-mp5r82g4 367 13 significant significant JJ cord-354029-mp5r82g4 367 14 number number NN cord-354029-mp5r82g4 367 15 of of IN cord-354029-mp5r82g4 367 16 glycines glycine NNS cord-354029-mp5r82g4 367 17 and and CC cord-354029-mp5r82g4 367 18 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 367 19 residues residue NNS cord-354029-mp5r82g4 367 20 ( ( -LRB- cord-354029-mp5r82g4 367 21 Fig Fig NNP cord-354029-mp5r82g4 367 22 . . . cord-354029-mp5r82g4 367 23 5A 5a CD cord-354029-mp5r82g4 367 24 ) ) -RRB- cord-354029-mp5r82g4 367 25 . . . cord-354029-mp5r82g4 368 1 Changing change VBG cord-354029-mp5r82g4 368 2 either either CC cord-354029-mp5r82g4 368 3 of of IN cord-354029-mp5r82g4 368 4 two two CD cord-354029-mp5r82g4 368 5 glycines glycine NNS cord-354029-mp5r82g4 368 6 within within IN cord-354029-mp5r82g4 368 7 the the DT cord-354029-mp5r82g4 368 8 SFV SFV NNP cord-354029-mp5r82g4 368 9 E1 e1 NN cord-354029-mp5r82g4 368 10 fusion fusion NN cord-354029-mp5r82g4 368 11 peptide peptide NN cord-354029-mp5r82g4 368 12 to to IN cord-354029-mp5r82g4 368 13 alanines alanine NNS cord-354029-mp5r82g4 368 14 altered alter VBD cord-354029-mp5r82g4 368 15 the the DT cord-354029-mp5r82g4 368 16 pH pH NNP cord-354029-mp5r82g4 368 17 threshold threshold NN cord-354029-mp5r82g4 368 18 for for IN cord-354029-mp5r82g4 368 19 fusion fusion NN cord-354029-mp5r82g4 368 20 , , , cord-354029-mp5r82g4 368 21 and and CC cord-354029-mp5r82g4 368 22 changing change VBG cord-354029-mp5r82g4 368 23 one one CD cord-354029-mp5r82g4 368 24 of of IN cord-354029-mp5r82g4 368 25 the the DT cord-354029-mp5r82g4 368 26 glycines glycine NNS cord-354029-mp5r82g4 368 27 to to IN cord-354029-mp5r82g4 368 28 aspartic aspartic JJ cord-354029-mp5r82g4 368 29 acid acid NN cord-354029-mp5r82g4 368 30 abolished abolish VBN cord-354029-mp5r82g4 368 31 fusion fusion NN cord-354029-mp5r82g4 368 32 ( ( -LRB- cord-354029-mp5r82g4 368 33 Duffus Duffus NNP cord-354029-mp5r82g4 368 34 et et NNP cord-354029-mp5r82g4 368 35 al al NNP cord-354029-mp5r82g4 368 36 . . NNP cord-354029-mp5r82g4 368 37 1995 1995 CD cord-354029-mp5r82g4 368 38 ; ; : cord-354029-mp5r82g4 368 39 Kielian Kielian NNP cord-354029-mp5r82g4 368 40 et et NNP cord-354029-mp5r82g4 368 41 al al NNP cord-354029-mp5r82g4 368 42 . . . cord-354029-mp5r82g4 368 43 1996 1996 CD cord-354029-mp5r82g4 368 44 ) ) -RRB- cord-354029-mp5r82g4 368 45 . . . cord-354029-mp5r82g4 369 1 Alteration alteration NN cord-354029-mp5r82g4 369 2 of of IN cord-354029-mp5r82g4 369 3 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 369 4 residues residue NNS cord-354029-mp5r82g4 369 5 at at IN cord-354029-mp5r82g4 369 6 the the DT cord-354029-mp5r82g4 369 7 beginning beginning NN cord-354029-mp5r82g4 369 8 , , , cord-354029-mp5r82g4 369 9 middle middle JJ cord-354029-mp5r82g4 369 10 , , , cord-354029-mp5r82g4 369 11 or or CC cord-354029-mp5r82g4 369 12 end end NN cord-354029-mp5r82g4 369 13 of of IN cord-354029-mp5r82g4 369 14 the the DT cord-354029-mp5r82g4 369 15 ( ( -LRB- cord-354029-mp5r82g4 369 16 internal internal JJ cord-354029-mp5r82g4 369 17 ) ) -RRB- cord-354029-mp5r82g4 369 18 ASLV ASLV NNP cord-354029-mp5r82g4 369 19 EnvA EnvA NNP cord-354029-mp5r82g4 369 20 fusion fusion NN cord-354029-mp5r82g4 369 21 peptide peptide NN cord-354029-mp5r82g4 369 22 to to IN cord-354029-mp5r82g4 369 23 charged charge VBN cord-354029-mp5r82g4 369 24 residues residue NNS cord-354029-mp5r82g4 369 25 impaired impair VBD cord-354029-mp5r82g4 369 26 the the DT cord-354029-mp5r82g4 369 27 ability ability NN cord-354029-mp5r82g4 369 28 of of IN cord-354029-mp5r82g4 369 29 EnvA EnvA NNP cord-354029-mp5r82g4 369 30 to to TO cord-354029-mp5r82g4 369 31 mediate mediate VB cord-354029-mp5r82g4 369 32 fusion fusion NN cord-354029-mp5r82g4 369 33 ( ( -LRB- cord-354029-mp5r82g4 369 34 Hernandez Hernandez NNP cord-354029-mp5r82g4 369 35 and and CC cord-354029-mp5r82g4 369 36 White White NNP cord-354029-mp5r82g4 369 37 1998 1998 CD cord-354029-mp5r82g4 369 38 ) ) -RRB- cord-354029-mp5r82g4 369 39 . . . cord-354029-mp5r82g4 370 1 Similarly similarly RB cord-354029-mp5r82g4 370 2 , , , cord-354029-mp5r82g4 370 3 a a DT cord-354029-mp5r82g4 370 4 tryptophan tryptophan NN cord-354029-mp5r82g4 370 5 and and CC cord-354029-mp5r82g4 370 6 a a DT cord-354029-mp5r82g4 370 7 glycine glycine NN cord-354029-mp5r82g4 370 8 are be VBP cord-354029-mp5r82g4 370 9 critical critical JJ cord-354029-mp5r82g4 370 10 for for IN cord-354029-mp5r82g4 370 11 Ebola Ebola NNP cord-354029-mp5r82g4 370 12 GP GP NNP cord-354029-mp5r82g4 370 13 - - HYPH cord-354029-mp5r82g4 370 14 mediated mediate VBN cord-354029-mp5r82g4 370 15 infection infection NN cord-354029-mp5r82g4 370 16 ( ( -LRB- cord-354029-mp5r82g4 370 17 Ito Ito NNP cord-354029-mp5r82g4 370 18 et et FW cord-354029-mp5r82g4 370 19 al al NNP cord-354029-mp5r82g4 370 20 . . . cord-354029-mp5r82g4 370 21 1999 1999 CD cord-354029-mp5r82g4 370 22 ) ) -RRB- cord-354029-mp5r82g4 370 23 . . . cord-354029-mp5r82g4 371 1 Also also RB cord-354029-mp5r82g4 371 2 , , , cord-354029-mp5r82g4 371 3 a a DT cord-354029-mp5r82g4 371 4 bulky bulky JJ cord-354029-mp5r82g4 371 5 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 371 6 residue residue NN cord-354029-mp5r82g4 371 7 is be VBZ cord-354029-mp5r82g4 371 8 needed need VBN cord-354029-mp5r82g4 371 9 at at IN cord-354029-mp5r82g4 371 10 the the DT cord-354029-mp5r82g4 371 11 tip tip NN cord-354029-mp5r82g4 371 12 of of IN cord-354029-mp5r82g4 371 13 the the DT cord-354029-mp5r82g4 371 14 TBE TBE NNP cord-354029-mp5r82g4 371 15 E e NN cord-354029-mp5r82g4 371 16 fusion fusion NN cord-354029-mp5r82g4 371 17 peptide peptide NN cord-354029-mp5r82g4 371 18 loop loop NN cord-354029-mp5r82g4 371 19 ( ( -LRB- cord-354029-mp5r82g4 371 20 Rey Rey NNP cord-354029-mp5r82g4 371 21 et et NNP cord-354029-mp5r82g4 371 22 al al NNP cord-354029-mp5r82g4 371 23 . . NNP cord-354029-mp5r82g4 371 24 1995 1995 CD cord-354029-mp5r82g4 371 25 ) ) -RRB- cord-354029-mp5r82g4 372 1 ( ( -LRB- cord-354029-mp5r82g4 372 2 Fig Fig NNP cord-354029-mp5r82g4 372 3 . . . cord-354029-mp5r82g4 372 4 4A 4a CD cord-354029-mp5r82g4 372 5 , , , cord-354029-mp5r82g4 372 6 red red JJ cord-354029-mp5r82g4 372 7 ) ) -RRB- cord-354029-mp5r82g4 372 8 . . . cord-354029-mp5r82g4 373 1 Collectively collectively RB cord-354029-mp5r82g4 373 2 , , , cord-354029-mp5r82g4 373 3 these these DT cord-354029-mp5r82g4 373 4 results result NNS cord-354029-mp5r82g4 373 5 suggest suggest VBP cord-354029-mp5r82g4 373 6 that that IN cord-354029-mp5r82g4 373 7 internal internal JJ cord-354029-mp5r82g4 373 8 fusion fusion NN cord-354029-mp5r82g4 373 9 peptides peptide NNS cord-354029-mp5r82g4 373 10 function function VBP cord-354029-mp5r82g4 373 11 as as IN cord-354029-mp5r82g4 373 12 loops loop NNS cord-354029-mp5r82g4 373 13 that that WDT cord-354029-mp5r82g4 373 14 require require VBP cord-354029-mp5r82g4 373 15 a a DT cord-354029-mp5r82g4 373 16 mixture mixture NN cord-354029-mp5r82g4 373 17 of of IN cord-354029-mp5r82g4 373 18 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 373 19 and and CC cord-354029-mp5r82g4 373 20 flexible flexible JJ cord-354029-mp5r82g4 373 21 residues residue NNS cord-354029-mp5r82g4 373 22 , , , cord-354029-mp5r82g4 373 23 similar similar JJ cord-354029-mp5r82g4 373 24 to to IN cord-354029-mp5r82g4 373 25 those those DT cord-354029-mp5r82g4 373 26 found find VBN cord-354029-mp5r82g4 373 27 in in IN cord-354029-mp5r82g4 373 28 N n CD cord-354029-mp5r82g4 373 29 - - HYPH cord-354029-mp5r82g4 373 30 terminal terminal NN cord-354029-mp5r82g4 373 31 fusion fusion NN cord-354029-mp5r82g4 373 32 peptides peptide NNS cord-354029-mp5r82g4 373 33 . . . cord-354029-mp5r82g4 374 1 Fusion fusion NN cord-354029-mp5r82g4 374 2 peptides peptide NNS cord-354029-mp5r82g4 374 3 appear appear VBP cord-354029-mp5r82g4 374 4 to to TO cord-354029-mp5r82g4 374 5 act act VB cord-354029-mp5r82g4 374 6 at at IN cord-354029-mp5r82g4 374 7 several several JJ cord-354029-mp5r82g4 374 8 steps step NNS cord-354029-mp5r82g4 374 9 along along IN cord-354029-mp5r82g4 374 10 the the DT cord-354029-mp5r82g4 374 11 fusion fusion NN cord-354029-mp5r82g4 374 12 pathway pathway NN cord-354029-mp5r82g4 374 13 . . . cord-354029-mp5r82g4 375 1 As as IN cord-354029-mp5r82g4 375 2 demonstrated demonstrate VBN cord-354029-mp5r82g4 375 3 by by IN cord-354029-mp5r82g4 375 4 mutants mutant NNS cord-354029-mp5r82g4 375 5 in in IN cord-354029-mp5r82g4 375 6 which which WDT cord-354029-mp5r82g4 375 7 apolar apolar NNP cord-354029-mp5r82g4 375 8 fusion fusion NN cord-354029-mp5r82g4 375 9 peptide peptide NN cord-354029-mp5r82g4 375 10 residues residue NNS cord-354029-mp5r82g4 375 11 were be VBD cord-354029-mp5r82g4 375 12 changed change VBN cord-354029-mp5r82g4 375 13 to to IN cord-354029-mp5r82g4 375 14 charged charge VBN cord-354029-mp5r82g4 375 15 residues residue NNS cord-354029-mp5r82g4 375 16 ( ( -LRB- cord-354029-mp5r82g4 375 17 Freed Freed NNP cord-354029-mp5r82g4 375 18 et et FW cord-354029-mp5r82g4 375 19 al al NNP cord-354029-mp5r82g4 375 20 . . . cord-354029-mp5r82g4 375 21 1992 1992 CD cord-354029-mp5r82g4 375 22 ; ; : cord-354029-mp5r82g4 375 23 Gething Gething NNP cord-354029-mp5r82g4 375 24 et et FW cord-354029-mp5r82g4 375 25 al al NNP cord-354029-mp5r82g4 375 26 . . NNP cord-354029-mp5r82g4 375 27 1986 1986 CD cord-354029-mp5r82g4 375 28 ; ; : cord-354029-mp5r82g4 375 29 Hernandez Hernandez NNP cord-354029-mp5r82g4 375 30 and and CC cord-354029-mp5r82g4 375 31 White White NNP cord-354029-mp5r82g4 375 32 1998 1998 CD cord-354029-mp5r82g4 375 33 ; ; : cord-354029-mp5r82g4 375 34 Schoch Schoch NNP cord-354029-mp5r82g4 375 35 and and CC cord-354029-mp5r82g4 375 36 Blumenthal Blumenthal NNP cord-354029-mp5r82g4 375 37 1993 1993 CD cord-354029-mp5r82g4 375 38 ) ) -RRB- cord-354029-mp5r82g4 375 39 , , , cord-354029-mp5r82g4 375 40 fusion fusion NN cord-354029-mp5r82g4 375 41 peptides peptide NNS cord-354029-mp5r82g4 375 42 clearly clearly RB cord-354029-mp5r82g4 375 43 play play VBP cord-354029-mp5r82g4 375 44 an an DT cord-354029-mp5r82g4 375 45 important important JJ cord-354029-mp5r82g4 375 46 role role NN cord-354029-mp5r82g4 375 47 in in IN cord-354029-mp5r82g4 375 48 anchoring anchor VBG cord-354029-mp5r82g4 375 49 the the DT cord-354029-mp5r82g4 375 50 fusion fusion NN cord-354029-mp5r82g4 375 51 protein protein NN cord-354029-mp5r82g4 375 52 to to IN cord-354029-mp5r82g4 375 53 the the DT cord-354029-mp5r82g4 375 54 target target NN cord-354029-mp5r82g4 375 55 membrane membrane NN cord-354029-mp5r82g4 375 56 ( ( -LRB- cord-354029-mp5r82g4 375 57 Fig Fig NNP cord-354029-mp5r82g4 375 58 . . . cord-354029-mp5r82g4 375 59 3 3 CD cord-354029-mp5r82g4 375 60 , , , cord-354029-mp5r82g4 375 61 Step step NN cord-354029-mp5r82g4 375 62 2 2 CD cord-354029-mp5r82g4 375 63 ) ) -RRB- cord-354029-mp5r82g4 375 64 . . . cord-354029-mp5r82g4 376 1 The the DT cord-354029-mp5r82g4 376 2 energy energy NN cord-354029-mp5r82g4 376 3 provided provide VBN cord-354029-mp5r82g4 376 4 by by IN cord-354029-mp5r82g4 376 5 inserting insert VBG cord-354029-mp5r82g4 376 6 the the DT cord-354029-mp5r82g4 376 7 fusion fusion NN cord-354029-mp5r82g4 376 8 peptides peptide NNS cord-354029-mp5r82g4 376 9 of of IN cord-354029-mp5r82g4 376 10 a a DT cord-354029-mp5r82g4 376 11 single single JJ cord-354029-mp5r82g4 376 12 HA HA NNP cord-354029-mp5r82g4 376 13 trimer trimer NN cord-354029-mp5r82g4 376 14 into into IN cord-354029-mp5r82g4 376 15 a a DT cord-354029-mp5r82g4 376 16 membrane membrane NN cord-354029-mp5r82g4 376 17 would would MD cord-354029-mp5r82g4 376 18 be be VB cord-354029-mp5r82g4 376 19 sufficient sufficient JJ cord-354029-mp5r82g4 376 20 to to TO cord-354029-mp5r82g4 376 21 initiate initiate VB cord-354029-mp5r82g4 376 22 stalk stalk VB cord-354029-mp5r82g4 376 23 formation formation NN cord-354029-mp5r82g4 377 1 ( ( -LRB- cord-354029-mp5r82g4 377 2 Gunther Gunther NNP cord-354029-mp5r82g4 377 3 - - HYPH cord-354029-mp5r82g4 377 4 Ausborn Ausborn NNP cord-354029-mp5r82g4 377 5 et et NNP cord-354029-mp5r82g4 377 6 al al NNP cord-354029-mp5r82g4 377 7 . . . cord-354029-mp5r82g4 377 8 2000 2000 CD cord-354029-mp5r82g4 377 9 ) ) -RRB- cord-354029-mp5r82g4 377 10 . . . cord-354029-mp5r82g4 378 1 The the DT cord-354029-mp5r82g4 378 2 fusion fusion NN cord-354029-mp5r82g4 378 3 peptide peptide NN cord-354029-mp5r82g4 378 4 may may MD cord-354029-mp5r82g4 378 5 also also RB cord-354029-mp5r82g4 378 6 assist assist VB cord-354029-mp5r82g4 378 7 in in IN cord-354029-mp5r82g4 378 8 creating create VBG cord-354029-mp5r82g4 378 9 the the DT cord-354029-mp5r82g4 378 10 stalk stalk NN cord-354029-mp5r82g4 378 11 by by IN cord-354029-mp5r82g4 378 12 displacing displace VBG cord-354029-mp5r82g4 378 13 water water NN cord-354029-mp5r82g4 378 14 from from IN cord-354029-mp5r82g4 378 15 the the DT cord-354029-mp5r82g4 378 16 lipid lipid NN cord-354029-mp5r82g4 378 17 - - HYPH cord-354029-mp5r82g4 378 18 water water NN cord-354029-mp5r82g4 378 19 interface interface NN cord-354029-mp5r82g4 378 20 , , , cord-354029-mp5r82g4 378 21 thus thus RB cord-354029-mp5r82g4 378 22 decreasing decrease VBG cord-354029-mp5r82g4 378 23 the the DT cord-354029-mp5r82g4 378 24 repulsive repulsive JJ cord-354029-mp5r82g4 378 25 force force NN cord-354029-mp5r82g4 378 26 between between IN cord-354029-mp5r82g4 378 27 the the DT cord-354029-mp5r82g4 378 28 two two CD cord-354029-mp5r82g4 378 29 fusing fuse VBG cord-354029-mp5r82g4 378 30 membranes membrane NNS cord-354029-mp5r82g4 378 31 ( ( -LRB- cord-354029-mp5r82g4 378 32 Tamm Tamm NNP cord-354029-mp5r82g4 378 33 and and CC cord-354029-mp5r82g4 378 34 Han Han NNP cord-354029-mp5r82g4 378 35 2000 2000 CD cord-354029-mp5r82g4 378 36 ) ) -RRB- cord-354029-mp5r82g4 378 37 . . . cord-354029-mp5r82g4 379 1 Fusion fusion NN cord-354029-mp5r82g4 379 2 peptides peptide NNS cord-354029-mp5r82g4 379 3 may may MD cord-354029-mp5r82g4 379 4 also also RB cord-354029-mp5r82g4 379 5 function function VB cord-354029-mp5r82g4 379 6 in in IN cord-354029-mp5r82g4 379 7 fusion fusion NN cord-354029-mp5r82g4 379 8 pore pore NN cord-354029-mp5r82g4 379 9 opening opening NN cord-354029-mp5r82g4 379 10 . . . cord-354029-mp5r82g4 380 1 In in IN cord-354029-mp5r82g4 380 2 support support NN cord-354029-mp5r82g4 380 3 of of IN cord-354029-mp5r82g4 380 4 this this DT cord-354029-mp5r82g4 380 5 possibility possibility NN cord-354029-mp5r82g4 380 6 is be VBZ cord-354029-mp5r82g4 380 7 the the DT cord-354029-mp5r82g4 380 8 observation observation NN cord-354029-mp5r82g4 380 9 that that IN cord-354029-mp5r82g4 380 10 an an DT cord-354029-mp5r82g4 380 11 HA HA NNP cord-354029-mp5r82g4 380 12 mutant mutant NN cord-354029-mp5r82g4 380 13 in in IN cord-354029-mp5r82g4 380 14 which which WDT cord-354029-mp5r82g4 380 15 Gly1 Gly1 NNP cord-354029-mp5r82g4 380 16 was be VBD cord-354029-mp5r82g4 380 17 changed change VBN cord-354029-mp5r82g4 380 18 to to IN cord-354029-mp5r82g4 380 19 serine serine NN cord-354029-mp5r82g4 380 20 mediates mediate VBZ cord-354029-mp5r82g4 380 21 extensive extensive JJ cord-354029-mp5r82g4 380 22 lipid lipid NN cord-354029-mp5r82g4 380 23 , , , cord-354029-mp5r82g4 380 24 but but CC cord-354029-mp5r82g4 380 25 not not RB cord-354029-mp5r82g4 380 26 content content NN cord-354029-mp5r82g4 380 27 mixing mixing NN cord-354029-mp5r82g4 380 28 ( ( -LRB- cord-354029-mp5r82g4 380 29 Qiao Qiao NNP cord-354029-mp5r82g4 380 30 et et FW cord-354029-mp5r82g4 380 31 al al NNP cord-354029-mp5r82g4 380 32 . . . cord-354029-mp5r82g4 380 33 1999 1999 CD cord-354029-mp5r82g4 380 34 ) ) -RRB- cord-354029-mp5r82g4 380 35 . . . cord-354029-mp5r82g4 381 1 Furthermore furthermore RB cord-354029-mp5r82g4 381 2 , , , cord-354029-mp5r82g4 381 3 defects defect NNS cord-354029-mp5r82g4 381 4 in in IN cord-354029-mp5r82g4 381 5 syncytium syncytium NN cord-354029-mp5r82g4 381 6 formation formation NN cord-354029-mp5r82g4 381 7 and and CC cord-354029-mp5r82g4 381 8 infectivity infectivity NN cord-354029-mp5r82g4 381 9 were be VBD cord-354029-mp5r82g4 381 10 observed observe VBN cord-354029-mp5r82g4 381 11 for for IN cord-354029-mp5r82g4 381 12 HIV HIV NNP cord-354029-mp5r82g4 381 13 Env Env NNP cord-354029-mp5r82g4 381 14 harboring harbor VBG cord-354029-mp5r82g4 381 15 the the DT cord-354029-mp5r82g4 381 16 mutation mutation NN cord-354029-mp5r82g4 381 17 V2E v2e NN cord-354029-mp5r82g4 381 18 in in IN cord-354029-mp5r82g4 381 19 its -PRON- PRP$ cord-354029-mp5r82g4 381 20 fusion fusion NN cord-354029-mp5r82g4 381 21 peptide peptide NN cord-354029-mp5r82g4 381 22 ( ( -LRB- cord-354029-mp5r82g4 381 23 Freed Freed NNP cord-354029-mp5r82g4 381 24 et et NNP cord-354029-mp5r82g4 381 25 al al NNP cord-354029-mp5r82g4 381 26 . . NNP cord-354029-mp5r82g4 381 27 1992 1992 CD cord-354029-mp5r82g4 381 28 ) ) -RRB- cord-354029-mp5r82g4 381 29 . . . cord-354029-mp5r82g4 382 1 Biophysical Biophysical NNP cord-354029-mp5r82g4 382 2 studies study NNS cord-354029-mp5r82g4 382 3 comparing compare VBG cord-354029-mp5r82g4 382 4 a a DT cord-354029-mp5r82g4 382 5 synthetic synthetic JJ cord-354029-mp5r82g4 382 6 fusion fusion NN cord-354029-mp5r82g4 382 7 peptide peptide NN cord-354029-mp5r82g4 382 8 harboring harbor VBG cord-354029-mp5r82g4 382 9 this this DT cord-354029-mp5r82g4 382 10 mutation mutation NN cord-354029-mp5r82g4 382 11 with with IN cord-354029-mp5r82g4 382 12 the the DT cord-354029-mp5r82g4 382 13 wild wild JJ cord-354029-mp5r82g4 382 14 - - HYPH cord-354029-mp5r82g4 382 15 type type NN cord-354029-mp5r82g4 382 16 peptide peptide NN cord-354029-mp5r82g4 382 17 suggested suggest VBD cord-354029-mp5r82g4 382 18 a a DT cord-354029-mp5r82g4 382 19 requirement requirement NN cord-354029-mp5r82g4 382 20 for for IN cord-354029-mp5r82g4 382 21 fusion fusion NN cord-354029-mp5r82g4 382 22 peptide peptide NN cord-354029-mp5r82g4 382 23 aggregation aggregation NN cord-354029-mp5r82g4 382 24 in in IN cord-354029-mp5r82g4 382 25 the the DT cord-354029-mp5r82g4 382 26 creation creation NN cord-354029-mp5r82g4 382 27 of of IN cord-354029-mp5r82g4 382 28 the the DT cord-354029-mp5r82g4 382 29 HIV HIV NNP cord-354029-mp5r82g4 382 30 fusion fusion NN cord-354029-mp5r82g4 382 31 pore pore NN cord-354029-mp5r82g4 382 32 Pereira Pereira NNP cord-354029-mp5r82g4 382 33 et et NNP cord-354029-mp5r82g4 382 34 al al NNP cord-354029-mp5r82g4 382 35 . . NNP cord-354029-mp5r82g4 382 36 1995 1995 CD cord-354029-mp5r82g4 382 37 ) ) -RRB- cord-354029-mp5r82g4 382 38 . . . cord-354029-mp5r82g4 383 1 Studies study NNS cord-354029-mp5r82g4 383 2 with with IN cord-354029-mp5r82g4 383 3 chimeric chimeric JJ cord-354029-mp5r82g4 383 4 fusion fusion NN cord-354029-mp5r82g4 383 5 proteins protein NNS cord-354029-mp5r82g4 383 6 have have VBP cord-354029-mp5r82g4 383 7 suggested suggest VBN cord-354029-mp5r82g4 383 8 that that IN cord-354029-mp5r82g4 383 9 the the DT cord-354029-mp5r82g4 383 10 transmembrane transmembrane NN cord-354029-mp5r82g4 383 11 domains domain NNS cord-354029-mp5r82g4 383 12 of of IN cord-354029-mp5r82g4 383 13 some some DT cord-354029-mp5r82g4 383 14 viral viral JJ cord-354029-mp5r82g4 383 15 fusion fusion NN cord-354029-mp5r82g4 383 16 proteins protein NNS cord-354029-mp5r82g4 383 17 do do VBP cord-354029-mp5r82g4 383 18 not not RB cord-354029-mp5r82g4 383 19 require require VB cord-354029-mp5r82g4 383 20 a a DT cord-354029-mp5r82g4 383 21 specific specific JJ cord-354029-mp5r82g4 383 22 sequence sequence NN cord-354029-mp5r82g4 383 23 to to TO cord-354029-mp5r82g4 383 24 support support VB cord-354029-mp5r82g4 383 25 fusion fusion NN cord-354029-mp5r82g4 383 26 ( ( -LRB- cord-354029-mp5r82g4 383 27 Armstrong Armstrong NNP cord-354029-mp5r82g4 383 28 et et NNP cord-354029-mp5r82g4 383 29 al al NNP cord-354029-mp5r82g4 383 30 . . . cord-354029-mp5r82g4 384 1 2000 2000 CD cord-354029-mp5r82g4 384 2 and and CC cord-354029-mp5r82g4 384 3 references reference NNS cord-354029-mp5r82g4 384 4 therein therein RB cord-354029-mp5r82g4 384 5 ) ) -RRB- cord-354029-mp5r82g4 384 6 . . . cord-354029-mp5r82g4 385 1 In in IN cord-354029-mp5r82g4 385 2 contrast contrast NN cord-354029-mp5r82g4 385 3 , , , cord-354029-mp5r82g4 385 4 studies study NNS cord-354029-mp5r82g4 385 5 with with IN cord-354029-mp5r82g4 385 6 glycosylphosphatidylinositol glycosylphosphatidylinositol NNP cord-354029-mp5r82g4 385 7 ( ( -LRB- cord-354029-mp5r82g4 385 8 GPI)-anchored gpi)-anchored JJ cord-354029-mp5r82g4 385 9 fusion fusion NN cord-354029-mp5r82g4 385 10 proteins protein NNS cord-354029-mp5r82g4 385 11 have have VBP cord-354029-mp5r82g4 385 12 demonstrated demonstrate VBN cord-354029-mp5r82g4 385 13 that that IN cord-354029-mp5r82g4 385 14 there there EX cord-354029-mp5r82g4 385 15 is be VBZ cord-354029-mp5r82g4 385 16 a a DT cord-354029-mp5r82g4 385 17 strict strict JJ cord-354029-mp5r82g4 385 18 requirement requirement NN cord-354029-mp5r82g4 385 19 for for IN cord-354029-mp5r82g4 385 20 a a DT cord-354029-mp5r82g4 385 21 proteinaceous proteinaceous JJ cord-354029-mp5r82g4 385 22 membrane membrane NN cord-354029-mp5r82g4 385 23 anchor anchor NN cord-354029-mp5r82g4 385 24 for for IN cord-354029-mp5r82g4 385 25 fusion fusion NN cord-354029-mp5r82g4 385 26 proteins protein NNS cord-354029-mp5r82g4 385 27 to to TO cord-354029-mp5r82g4 385 28 efficiently efficiently RB cord-354029-mp5r82g4 385 29 mediate mediate VB cord-354029-mp5r82g4 385 30 the the DT cord-354029-mp5r82g4 385 31 transition transition NN cord-354029-mp5r82g4 385 32 from from IN cord-354029-mp5r82g4 385 33 hemifusion hemifusion NN cord-354029-mp5r82g4 385 34 to to IN cord-354029-mp5r82g4 385 35 full full JJ cord-354029-mp5r82g4 385 36 fusion fusion NN cord-354029-mp5r82g4 385 37 ( ( -LRB- cord-354029-mp5r82g4 385 38 Kemble Kemble NNP cord-354029-mp5r82g4 385 39 et et FW cord-354029-mp5r82g4 385 40 al al NNP cord-354029-mp5r82g4 385 41 . . . cord-354029-mp5r82g4 385 42 1994 1994 CD cord-354029-mp5r82g4 385 43 ; ; : cord-354029-mp5r82g4 385 44 Melikyan Melikyan NNP cord-354029-mp5r82g4 385 45 et et NNP cord-354029-mp5r82g4 385 46 al al NNP cord-354029-mp5r82g4 385 47 . . . cord-354029-mp5r82g4 386 1 1997a 1997a CD cord-354029-mp5r82g4 386 2 ; ; : cord-354029-mp5r82g4 386 3 Tong Tong NNP cord-354029-mp5r82g4 386 4 and and CC cord-354029-mp5r82g4 386 5 Compans Compans NNP cord-354029-mp5r82g4 386 6 2000 2000 CD cord-354029-mp5r82g4 386 7 ) ) -RRB- cord-354029-mp5r82g4 386 8 . . . cord-354029-mp5r82g4 387 1 There there EX cord-354029-mp5r82g4 387 2 also also RB cord-354029-mp5r82g4 387 3 appears appear VBZ cord-354029-mp5r82g4 387 4 to to TO cord-354029-mp5r82g4 387 5 be be VB cord-354029-mp5r82g4 387 6 a a DT cord-354029-mp5r82g4 387 7 minimum minimum JJ cord-354029-mp5r82g4 387 8 length length NN cord-354029-mp5r82g4 387 9 for for IN cord-354029-mp5r82g4 387 10 the the DT cord-354029-mp5r82g4 387 11 fusion fusion NN cord-354029-mp5r82g4 387 12 protein protein NN cord-354029-mp5r82g4 387 13 transmembrane transmembrane NN cord-354029-mp5r82g4 387 14 domain domain NN cord-354029-mp5r82g4 387 15 to to TO cord-354029-mp5r82g4 387 16 be be VB cord-354029-mp5r82g4 387 17 able able JJ cord-354029-mp5r82g4 387 18 to to TO cord-354029-mp5r82g4 387 19 support support VB cord-354029-mp5r82g4 387 20 this this DT cord-354029-mp5r82g4 387 21 transition transition NN cord-354029-mp5r82g4 388 1 ( ( -LRB- cord-354029-mp5r82g4 388 2 Armstrong Armstrong NNP cord-354029-mp5r82g4 388 3 et et NNP cord-354029-mp5r82g4 388 4 al al NNP cord-354029-mp5r82g4 388 5 . . . cord-354029-mp5r82g4 389 1 2000 2000 CD cord-354029-mp5r82g4 389 2 ; ; : cord-354029-mp5r82g4 389 3 West West NNP cord-354029-mp5r82g4 389 4 et et NNP cord-354029-mp5r82g4 389 5 al al NNP cord-354029-mp5r82g4 389 6 . . NNP cord-354029-mp5r82g4 389 7 2001 2001 CD cord-354029-mp5r82g4 389 8 ) ) -RRB- cord-354029-mp5r82g4 389 9 . . . cord-354029-mp5r82g4 390 1 Therefore therefore RB cord-354029-mp5r82g4 390 2 , , , cord-354029-mp5r82g4 390 3 it -PRON- PRP cord-354029-mp5r82g4 390 4 has have VBZ cord-354029-mp5r82g4 390 5 been be VBN cord-354029-mp5r82g4 390 6 suggested suggest VBN cord-354029-mp5r82g4 390 7 that that IN cord-354029-mp5r82g4 390 8 fusion fusion NN cord-354029-mp5r82g4 390 9 protein protein NN cord-354029-mp5r82g4 390 10 transmembrane transmembrane NN cord-354029-mp5r82g4 390 11 domains domain NNS cord-354029-mp5r82g4 390 12 must must MD cord-354029-mp5r82g4 390 13 span span VB cord-354029-mp5r82g4 390 14 both both DT cord-354029-mp5r82g4 390 15 leaflets leaflet NNS cord-354029-mp5r82g4 390 16 of of IN cord-354029-mp5r82g4 390 17 the the DT cord-354029-mp5r82g4 390 18 viral viral JJ cord-354029-mp5r82g4 390 19 bilayer bilayer NN cord-354029-mp5r82g4 390 20 to to TO cord-354029-mp5r82g4 390 21 mediate mediate VB cord-354029-mp5r82g4 390 22 fusion fusion NN cord-354029-mp5r82g4 390 23 pore pore NN cord-354029-mp5r82g4 390 24 opening opening NN cord-354029-mp5r82g4 390 25 ( ( -LRB- cord-354029-mp5r82g4 390 26 Armstrong Armstrong NNP cord-354029-mp5r82g4 390 27 et et NNP cord-354029-mp5r82g4 390 28 al al NNP cord-354029-mp5r82g4 390 29 . . . cord-354029-mp5r82g4 390 30 2000 2000 CD cord-354029-mp5r82g4 390 31 ) ) -RRB- cord-354029-mp5r82g4 390 32 . . . cord-354029-mp5r82g4 391 1 The the DT cord-354029-mp5r82g4 391 2 transmembrane transmembrane NN cord-354029-mp5r82g4 391 3 domains domain NNS cord-354029-mp5r82g4 391 4 of of IN cord-354029-mp5r82g4 391 5 some some DT cord-354029-mp5r82g4 391 6 fusion fusion NN cord-354029-mp5r82g4 391 7 proteins protein NNS cord-354029-mp5r82g4 391 8 appear appear VBP cord-354029-mp5r82g4 391 9 to to TO cord-354029-mp5r82g4 391 10 have have VB cord-354029-mp5r82g4 391 11 specific specific JJ cord-354029-mp5r82g4 391 12 amino amino NN cord-354029-mp5r82g4 391 13 acid acid NN cord-354029-mp5r82g4 391 14 requirements requirement NNS cord-354029-mp5r82g4 391 15 for for IN cord-354029-mp5r82g4 391 16 fusion fusion NN cord-354029-mp5r82g4 391 17 function function NN cord-354029-mp5r82g4 391 18 . . . cord-354029-mp5r82g4 392 1 For for IN cord-354029-mp5r82g4 392 2 example example NN cord-354029-mp5r82g4 392 3 , , , cord-354029-mp5r82g4 392 4 a a DT cord-354029-mp5r82g4 392 5 conserved conserve VBN cord-354029-mp5r82g4 392 6 positively positively RB cord-354029-mp5r82g4 392 7 charged charge VBN cord-354029-mp5r82g4 392 8 residue residue NN cord-354029-mp5r82g4 392 9 in in IN cord-354029-mp5r82g4 392 10 the the DT cord-354029-mp5r82g4 392 11 middle middle NN cord-354029-mp5r82g4 392 12 of of IN cord-354029-mp5r82g4 392 13 the the DT cord-354029-mp5r82g4 392 14 transmembrane transmembrane NN cord-354029-mp5r82g4 392 15 domains domain NNS cord-354029-mp5r82g4 392 16 of of IN cord-354029-mp5r82g4 392 17 certain certain JJ cord-354029-mp5r82g4 392 18 retroviral retroviral NN cord-354029-mp5r82g4 392 19 Envs Envs NNP cord-354029-mp5r82g4 392 20 appears appear VBZ cord-354029-mp5r82g4 392 21 to to TO cord-354029-mp5r82g4 392 22 be be VB cord-354029-mp5r82g4 392 23 important important JJ cord-354029-mp5r82g4 392 24 for for IN cord-354029-mp5r82g4 392 25 the the DT cord-354029-mp5r82g4 392 26 ability ability NN cord-354029-mp5r82g4 392 27 to to TO cord-354029-mp5r82g4 392 28 mediate mediate VB cord-354029-mp5r82g4 392 29 fusion fusion NN cord-354029-mp5r82g4 392 30 and and CC cord-354029-mp5r82g4 392 31 infection infection NN cord-354029-mp5r82g4 392 32 ( ( -LRB- cord-354029-mp5r82g4 392 33 Einfeld Einfeld NNP cord-354029-mp5r82g4 392 34 and and CC cord-354029-mp5r82g4 392 35 Hunter Hunter NNP cord-354029-mp5r82g4 392 36 1994 1994 CD cord-354029-mp5r82g4 392 37 ; ; : cord-354029-mp5r82g4 392 38 Owens Owens NNP cord-354029-mp5r82g4 392 39 et et NNP cord-354029-mp5r82g4 392 40 al al NNP cord-354029-mp5r82g4 392 41 . . . cord-354029-mp5r82g4 392 42 1994 1994 CD cord-354029-mp5r82g4 392 43 ; ; : cord-354029-mp5r82g4 392 44 Pietschmann Pietschmann NNP cord-354029-mp5r82g4 392 45 et et NNP cord-354029-mp5r82g4 392 46 al al NNP cord-354029-mp5r82g4 392 47 . . . cord-354029-mp5r82g4 393 1 2000 2000 CD cord-354029-mp5r82g4 393 2 ; ; : cord-354029-mp5r82g4 393 3 West West NNP cord-354029-mp5r82g4 393 4 et et NNP cord-354029-mp5r82g4 393 5 al al NNP cord-354029-mp5r82g4 393 6 . . NNP cord-354029-mp5r82g4 393 7 2001 2001 CD cord-354029-mp5r82g4 393 8 ) ) -RRB- cord-354029-mp5r82g4 393 9 . . . cord-354029-mp5r82g4 394 1 Two two CD cord-354029-mp5r82g4 394 2 glycine glycine NN cord-354029-mp5r82g4 394 3 residues residue NNS cord-354029-mp5r82g4 394 4 in in IN cord-354029-mp5r82g4 394 5 the the DT cord-354029-mp5r82g4 394 6 transmembrane transmembrane NN cord-354029-mp5r82g4 394 7 domain domain NN cord-354029-mp5r82g4 394 8 of of IN cord-354029-mp5r82g4 394 9 VSV VSV NNP cord-354029-mp5r82g4 394 10 - - HYPH cord-354029-mp5r82g4 394 11 G G NNP cord-354029-mp5r82g4 394 12 appear appear VBP cord-354029-mp5r82g4 394 13 to to TO cord-354029-mp5r82g4 394 14 be be VB cord-354029-mp5r82g4 394 15 important important JJ cord-354029-mp5r82g4 394 16 for for IN cord-354029-mp5r82g4 394 17 the the DT cord-354029-mp5r82g4 394 18 transition transition NN cord-354029-mp5r82g4 394 19 from from IN cord-354029-mp5r82g4 394 20 hemifusion hemifusion NN cord-354029-mp5r82g4 394 21 to to IN cord-354029-mp5r82g4 394 22 full full JJ cord-354029-mp5r82g4 394 23 fusion fusion NN cord-354029-mp5r82g4 394 24 ( ( -LRB- cord-354029-mp5r82g4 394 25 Cleverley Cleverley NNP cord-354029-mp5r82g4 394 26 and and CC cord-354029-mp5r82g4 394 27 Lenard Lenard NNP cord-354029-mp5r82g4 394 28 1998 1998 CD cord-354029-mp5r82g4 394 29 ) ) -RRB- cord-354029-mp5r82g4 394 30 . . . cord-354029-mp5r82g4 395 1 Studies study NNS cord-354029-mp5r82g4 395 2 using use VBG cord-354029-mp5r82g4 395 3 a a DT cord-354029-mp5r82g4 395 4 synthetic synthetic JJ cord-354029-mp5r82g4 395 5 peptide peptide NN cord-354029-mp5r82g4 395 6 corresponding correspond VBG cord-354029-mp5r82g4 395 7 to to IN cord-354029-mp5r82g4 395 8 the the DT cord-354029-mp5r82g4 395 9 mutant mutant JJ cord-354029-mp5r82g4 395 10 VSV VSV NNP cord-354029-mp5r82g4 395 11 - - HYPH cord-354029-mp5r82g4 395 12 G G NNP cord-354029-mp5r82g4 395 13 transmembrane transmembrane NN cord-354029-mp5r82g4 395 14 domain domain NN cord-354029-mp5r82g4 395 15 ( ( -LRB- cord-354029-mp5r82g4 395 16 Dennison Dennison NNP cord-354029-mp5r82g4 395 17 et et NNP cord-354029-mp5r82g4 395 18 al al NNP cord-354029-mp5r82g4 395 19 . . . cord-354029-mp5r82g4 395 20 2002 2002 CD cord-354029-mp5r82g4 395 21 ) ) -RRB- cord-354029-mp5r82g4 395 22 suggested suggest VBD cord-354029-mp5r82g4 395 23 that that IN cord-354029-mp5r82g4 395 24 the the DT cord-354029-mp5r82g4 395 25 VSV VSV NNP cord-354029-mp5r82g4 395 26 - - HYPH cord-354029-mp5r82g4 395 27 G G NNP cord-354029-mp5r82g4 395 28 transmembrane transmembrane NN cord-354029-mp5r82g4 395 29 domain domain NN cord-354029-mp5r82g4 395 30 lowers lower VBZ cord-354029-mp5r82g4 395 31 the the DT cord-354029-mp5r82g4 395 32 energy energy NN cord-354029-mp5r82g4 395 33 barrier barrier NN cord-354029-mp5r82g4 395 34 for for IN cord-354029-mp5r82g4 395 35 fusion fusion NN cord-354029-mp5r82g4 395 36 and and CC cord-354029-mp5r82g4 395 37 stabilizes stabilize VBZ cord-354029-mp5r82g4 395 38 the the DT cord-354029-mp5r82g4 395 39 transient transient JJ cord-354029-mp5r82g4 395 40 fusion fusion NN cord-354029-mp5r82g4 395 41 pore pore NN cord-354029-mp5r82g4 395 42 , , , cord-354029-mp5r82g4 395 43 thereby thereby RB cord-354029-mp5r82g4 395 44 promoting promote VBG cord-354029-mp5r82g4 395 45 its -PRON- PRP$ cord-354029-mp5r82g4 395 46 conversion conversion NN cord-354029-mp5r82g4 395 47 to to IN cord-354029-mp5r82g4 395 48 a a DT cord-354029-mp5r82g4 395 49 stable stable JJ cord-354029-mp5r82g4 395 50 fusion fusion NN cord-354029-mp5r82g4 395 51 pore pore NN cord-354029-mp5r82g4 395 52 . . . cord-354029-mp5r82g4 396 1 Two two CD cord-354029-mp5r82g4 396 2 glycines glycine NNS cord-354029-mp5r82g4 396 3 may may MD cord-354029-mp5r82g4 396 4 allow allow VB cord-354029-mp5r82g4 396 5 the the DT cord-354029-mp5r82g4 396 6 VSV VSV NNP cord-354029-mp5r82g4 396 7 - - HYPH cord-354029-mp5r82g4 396 8 G G NNP cord-354029-mp5r82g4 396 9 transmembrane transmembrane NN cord-354029-mp5r82g4 396 10 domain domain NN cord-354029-mp5r82g4 396 11 to to TO cord-354029-mp5r82g4 396 12 adopt adopt VB cord-354029-mp5r82g4 396 13 alternative alternative JJ cord-354029-mp5r82g4 396 14 conformations conformation NNS cord-354029-mp5r82g4 396 15 under under IN cord-354029-mp5r82g4 396 16 different different JJ cord-354029-mp5r82g4 396 17 conditions condition NNS cord-354029-mp5r82g4 396 18 , , , cord-354029-mp5r82g4 396 19 and and CC cord-354029-mp5r82g4 396 20 such such JJ cord-354029-mp5r82g4 396 21 flexibility flexibility NN cord-354029-mp5r82g4 396 22 may may MD cord-354029-mp5r82g4 396 23 be be VB cord-354029-mp5r82g4 396 24 important important JJ cord-354029-mp5r82g4 396 25 for for IN cord-354029-mp5r82g4 396 26 function function NN cord-354029-mp5r82g4 396 27 . . . cord-354029-mp5r82g4 397 1 The the DT cord-354029-mp5r82g4 397 2 transmembrane transmembrane NN cord-354029-mp5r82g4 397 3 domain domain NN cord-354029-mp5r82g4 397 4 of of IN cord-354029-mp5r82g4 397 5 HA HA NNP cord-354029-mp5r82g4 397 6 from from IN cord-354029-mp5r82g4 397 7 the the DT cord-354029-mp5r82g4 397 8 Japan Japan NNP cord-354029-mp5r82g4 398 1 ( ( -LRB- cord-354029-mp5r82g4 398 2 Melikyan Melikyan NNP cord-354029-mp5r82g4 398 3 et et NNP cord-354029-mp5r82g4 398 4 al al NNP cord-354029-mp5r82g4 398 5 . . NNP cord-354029-mp5r82g4 398 6 2000b 2000b CD cord-354029-mp5r82g4 398 7 ) ) -RRB- cord-354029-mp5r82g4 398 8 , , , cord-354029-mp5r82g4 398 9 but but CC cord-354029-mp5r82g4 398 10 not not RB cord-354029-mp5r82g4 398 11 the the DT cord-354029-mp5r82g4 398 12 X:31 X:31 NNS cord-354029-mp5r82g4 398 13 ( ( -LRB- cord-354029-mp5r82g4 398 14 Armstrong Armstrong NNP cord-354029-mp5r82g4 398 15 et et NNP cord-354029-mp5r82g4 398 16 al al NNP cord-354029-mp5r82g4 398 17 . . . cord-354029-mp5r82g4 398 18 2000 2000 CD cord-354029-mp5r82g4 398 19 ) ) -RRB- cord-354029-mp5r82g4 398 20 , , , cord-354029-mp5r82g4 398 21 strain strain NN cord-354029-mp5r82g4 398 22 of of IN cord-354029-mp5r82g4 398 23 influenza influenza NN cord-354029-mp5r82g4 398 24 appears appear VBZ cord-354029-mp5r82g4 398 25 to to TO cord-354029-mp5r82g4 398 26 require require VB cord-354029-mp5r82g4 398 27 a a DT cord-354029-mp5r82g4 398 28 glycine glycine NN cord-354029-mp5r82g4 398 29 near near IN cord-354029-mp5r82g4 398 30 the the DT cord-354029-mp5r82g4 398 31 middle middle NN cord-354029-mp5r82g4 398 32 . . . cord-354029-mp5r82g4 399 1 An an DT cord-354029-mp5r82g4 399 2 ability ability NN cord-354029-mp5r82g4 399 3 to to TO cord-354029-mp5r82g4 399 4 adopt adopt VB cord-354029-mp5r82g4 399 5 alternative alternative JJ cord-354029-mp5r82g4 399 6 conformations conformation NNS cord-354029-mp5r82g4 399 7 was be VBD cord-354029-mp5r82g4 399 8 also also RB cord-354029-mp5r82g4 399 9 invoked invoke VBN cord-354029-mp5r82g4 399 10 to to TO cord-354029-mp5r82g4 399 11 explain explain VB cord-354029-mp5r82g4 399 12 the the DT cord-354029-mp5r82g4 399 13 requirement requirement NN cord-354029-mp5r82g4 399 14 for for IN cord-354029-mp5r82g4 399 15 a a DT cord-354029-mp5r82g4 399 16 proline proline NN cord-354029-mp5r82g4 399 17 near near IN cord-354029-mp5r82g4 399 18 the the DT cord-354029-mp5r82g4 399 19 middle middle NN cord-354029-mp5r82g4 399 20 of of IN cord-354029-mp5r82g4 399 21 the the DT cord-354029-mp5r82g4 399 22 transmembrane transmembrane NN cord-354029-mp5r82g4 399 23 domain domain NN cord-354029-mp5r82g4 399 24 of of IN cord-354029-mp5r82g4 399 25 the the DT cord-354029-mp5r82g4 399 26 murine murine JJ cord-354029-mp5r82g4 399 27 leukemia leukemia NN cord-354029-mp5r82g4 399 28 virus virus NN cord-354029-mp5r82g4 399 29 ( ( -LRB- cord-354029-mp5r82g4 399 30 MLV MLV NNP cord-354029-mp5r82g4 399 31 ) ) -RRB- cord-354029-mp5r82g4 399 32 Env env NN cord-354029-mp5r82g4 399 33 glycoprotein glycoprotein NN cord-354029-mp5r82g4 399 34 ( ( -LRB- cord-354029-mp5r82g4 399 35 Taylor Taylor NNP cord-354029-mp5r82g4 399 36 and and CC cord-354029-mp5r82g4 399 37 Sanders Sanders NNP cord-354029-mp5r82g4 399 38 1999 1999 CD cord-354029-mp5r82g4 399 39 ) ) -RRB- cord-354029-mp5r82g4 399 40 . . . cord-354029-mp5r82g4 400 1 The the DT cord-354029-mp5r82g4 400 2 observations observation NNS cord-354029-mp5r82g4 400 3 that that WDT cord-354029-mp5r82g4 400 4 mutations mutation NNS cord-354029-mp5r82g4 400 5 in in IN cord-354029-mp5r82g4 400 6 fusion fusion NN cord-354029-mp5r82g4 400 7 peptides peptide NNS cord-354029-mp5r82g4 400 8 or or CC cord-354029-mp5r82g4 400 9 transmembrane transmembrane NN cord-354029-mp5r82g4 400 10 domains domain NNS cord-354029-mp5r82g4 400 11 ( ( -LRB- cord-354029-mp5r82g4 400 12 Armstrong Armstrong NNP cord-354029-mp5r82g4 400 13 et et NNP cord-354029-mp5r82g4 400 14 al al NNP cord-354029-mp5r82g4 400 15 . . . cord-354029-mp5r82g4 400 16 2000 2000 CD cord-354029-mp5r82g4 400 17 ; ; : cord-354029-mp5r82g4 400 18 Baker Baker NNP cord-354029-mp5r82g4 400 19 et et NNP cord-354029-mp5r82g4 400 20 al al NNP cord-354029-mp5r82g4 400 21 . . . cord-354029-mp5r82g4 400 22 1999 1999 CD cord-354029-mp5r82g4 400 23 ; ; : cord-354029-mp5r82g4 400 24 Tamm Tamm NNP cord-354029-mp5r82g4 400 25 et et NNP cord-354029-mp5r82g4 400 26 al al NNP cord-354029-mp5r82g4 400 27 . . . cord-354029-mp5r82g4 400 28 2002 2002 CD cord-354029-mp5r82g4 400 29 ) ) -RRB- cord-354029-mp5r82g4 400 30 can can MD cord-354029-mp5r82g4 400 31 impair impair VB cord-354029-mp5r82g4 400 32 the the DT cord-354029-mp5r82g4 400 33 ability ability NN cord-354029-mp5r82g4 400 34 to to TO cord-354029-mp5r82g4 400 35 mediate mediate VB cord-354029-mp5r82g4 400 36 full full JJ cord-354029-mp5r82g4 400 37 fusion fusion NN cord-354029-mp5r82g4 400 38 ( ( -LRB- cord-354029-mp5r82g4 400 39 Fig Fig NNP cord-354029-mp5r82g4 400 40 . . . cord-354029-mp5r82g4 400 41 3 3 CD cord-354029-mp5r82g4 400 42 , , , cord-354029-mp5r82g4 400 43 Step Step NNP cord-354029-mp5r82g4 400 44 6 6 CD cord-354029-mp5r82g4 400 45 ) ) -RRB- cord-354029-mp5r82g4 400 46 have have VBP cord-354029-mp5r82g4 400 47 suggested suggest VBN cord-354029-mp5r82g4 400 48 that that IN cord-354029-mp5r82g4 400 49 both both DT cord-354029-mp5r82g4 400 50 of of IN cord-354029-mp5r82g4 400 51 these these DT cord-354029-mp5r82g4 400 52 apolar apolar NNP cord-354029-mp5r82g4 400 53 domains domain NNS cord-354029-mp5r82g4 400 54 function function VBP cord-354029-mp5r82g4 400 55 in in IN cord-354029-mp5r82g4 400 56 the the DT cord-354029-mp5r82g4 400 57 transition transition NN cord-354029-mp5r82g4 400 58 from from IN cord-354029-mp5r82g4 400 59 hemifusion hemifusion NN cord-354029-mp5r82g4 400 60 to to IN cord-354029-mp5r82g4 400 61 full full JJ cord-354029-mp5r82g4 400 62 fusion fusion NN cord-354029-mp5r82g4 400 63 . . . cord-354029-mp5r82g4 401 1 Initially initially RB cord-354029-mp5r82g4 401 2 , , , cord-354029-mp5r82g4 401 3 the the DT cord-354029-mp5r82g4 401 4 fusion fusion NN cord-354029-mp5r82g4 401 5 peptide peptide NN cord-354029-mp5r82g4 401 6 appears appear VBZ cord-354029-mp5r82g4 401 7 to to TO cord-354029-mp5r82g4 401 8 insert insert VB cord-354029-mp5r82g4 401 9 only only RB cord-354029-mp5r82g4 401 10 into into IN cord-354029-mp5r82g4 401 11 the the DT cord-354029-mp5r82g4 401 12 outer outer JJ cord-354029-mp5r82g4 401 13 leaflet leaflet NN cord-354029-mp5r82g4 401 14 of of IN cord-354029-mp5r82g4 401 15 the the DT cord-354029-mp5r82g4 401 16 target target NN cord-354029-mp5r82g4 401 17 membrane membrane NN cord-354029-mp5r82g4 401 18 ( ( -LRB- cord-354029-mp5r82g4 401 19 Tamm Tamm NNP cord-354029-mp5r82g4 401 20 and and CC cord-354029-mp5r82g4 401 21 Han Han NNP cord-354029-mp5r82g4 401 22 2000 2000 CD cord-354029-mp5r82g4 401 23 ) ) -RRB- cord-354029-mp5r82g4 401 24 . . . cord-354029-mp5r82g4 402 1 It -PRON- PRP cord-354029-mp5r82g4 402 2 has have VBZ cord-354029-mp5r82g4 402 3 been be VBN cord-354029-mp5r82g4 402 4 proposed propose VBN cord-354029-mp5r82g4 402 5 that that IN cord-354029-mp5r82g4 402 6 the the DT cord-354029-mp5r82g4 402 7 transmembrane transmembrane NN cord-354029-mp5r82g4 402 8 domain domain NN cord-354029-mp5r82g4 402 9 and and CC cord-354029-mp5r82g4 402 10 the the DT cord-354029-mp5r82g4 402 11 fusion fusion NN cord-354029-mp5r82g4 402 12 peptide peptide NN cord-354029-mp5r82g4 402 13 , , , cord-354029-mp5r82g4 402 14 which which WDT cord-354029-mp5r82g4 402 15 are be VBP cord-354029-mp5r82g4 402 16 close close JJ cord-354029-mp5r82g4 402 17 to to IN cord-354029-mp5r82g4 402 18 each each DT cord-354029-mp5r82g4 402 19 other other JJ cord-354029-mp5r82g4 402 20 after after IN cord-354029-mp5r82g4 402 21 membrane membrane NN cord-354029-mp5r82g4 402 22 merger merger NN cord-354029-mp5r82g4 402 23 , , , cord-354029-mp5r82g4 402 24 may may MD cord-354029-mp5r82g4 402 25 interact interact VB cord-354029-mp5r82g4 402 26 to to TO cord-354029-mp5r82g4 402 27 stabilize stabilize VB cord-354029-mp5r82g4 402 28 the the DT cord-354029-mp5r82g4 402 29 fusion fusion NN cord-354029-mp5r82g4 402 30 pore pore NN cord-354029-mp5r82g4 402 31 ( ( -LRB- cord-354029-mp5r82g4 402 32 Tamm Tamm NNP cord-354029-mp5r82g4 402 33 et et NNP cord-354029-mp5r82g4 402 34 al al NNP cord-354029-mp5r82g4 402 35 . . . cord-354029-mp5r82g4 402 36 2002 2002 CD cord-354029-mp5r82g4 403 1 ; ; : cord-354029-mp5r82g4 403 2 Zhou Zhou NNP cord-354029-mp5r82g4 403 3 et et NNP cord-354029-mp5r82g4 403 4 al al NNP cord-354029-mp5r82g4 403 5 . . . cord-354029-mp5r82g4 403 6 1997 1997 CD cord-354029-mp5r82g4 403 7 ) ) -RRB- cord-354029-mp5r82g4 403 8 . . . cord-354029-mp5r82g4 404 1 If if IN cord-354029-mp5r82g4 404 2 this this DT cord-354029-mp5r82g4 404 3 is be VBZ cord-354029-mp5r82g4 404 4 the the DT cord-354029-mp5r82g4 404 5 case case NN cord-354029-mp5r82g4 404 6 , , , cord-354029-mp5r82g4 404 7 the the DT cord-354029-mp5r82g4 404 8 fusion fusion NN cord-354029-mp5r82g4 404 9 peptide peptide NN cord-354029-mp5r82g4 404 10 might may MD cord-354029-mp5r82g4 404 11 span span VB cord-354029-mp5r82g4 404 12 both both DT cord-354029-mp5r82g4 404 13 leaflets leaflet NNS cord-354029-mp5r82g4 404 14 of of IN cord-354029-mp5r82g4 404 15 the the DT cord-354029-mp5r82g4 404 16 fused fuse VBN cord-354029-mp5r82g4 404 17 membrane membrane NN cord-354029-mp5r82g4 404 18 in in IN cord-354029-mp5r82g4 404 19 its -PRON- PRP$ cord-354029-mp5r82g4 404 20 final final JJ cord-354029-mp5r82g4 404 21 conformation conformation NN cord-354029-mp5r82g4 405 1 ( ( -LRB- cord-354029-mp5r82g4 405 2 Tamm Tamm NNP cord-354029-mp5r82g4 405 3 et et NNP cord-354029-mp5r82g4 405 4 al al NNP cord-354029-mp5r82g4 405 5 . . . cord-354029-mp5r82g4 405 6 2002 2002 CD cord-354029-mp5r82g4 405 7 ) ) -RRB- cord-354029-mp5r82g4 405 8 . . . cord-354029-mp5r82g4 406 1 Several several JJ cord-354029-mp5r82g4 406 2 lines line NNS cord-354029-mp5r82g4 406 3 of of IN cord-354029-mp5r82g4 406 4 evidence evidence NN cord-354029-mp5r82g4 406 5 suggest suggest VBP cord-354029-mp5r82g4 406 6 that that IN cord-354029-mp5r82g4 406 7 ectodomain ectodomain JJ cord-354029-mp5r82g4 406 8 sequences sequence NNS cord-354029-mp5r82g4 406 9 that that WDT cord-354029-mp5r82g4 406 10 lie lie VBP cord-354029-mp5r82g4 406 11 just just RB cord-354029-mp5r82g4 406 12 before before IN cord-354029-mp5r82g4 406 13 the the DT cord-354029-mp5r82g4 406 14 transmembrane transmembrane NN cord-354029-mp5r82g4 406 15 domains domain NNS cord-354029-mp5r82g4 406 16 of of IN cord-354029-mp5r82g4 406 17 certain certain JJ cord-354029-mp5r82g4 406 18 viral viral JJ cord-354029-mp5r82g4 406 19 fusion fusion NN cord-354029-mp5r82g4 406 20 proteins protein NNS cord-354029-mp5r82g4 406 21 may may MD cord-354029-mp5r82g4 406 22 be be VB cord-354029-mp5r82g4 406 23 important important JJ cord-354029-mp5r82g4 406 24 for for IN cord-354029-mp5r82g4 406 25 fusion fusion NN cord-354029-mp5r82g4 406 26 . . . cord-354029-mp5r82g4 407 1 These these DT cord-354029-mp5r82g4 407 2 sequences sequence NNS cord-354029-mp5r82g4 407 3 tend tend VBP cord-354029-mp5r82g4 407 4 to to TO cord-354029-mp5r82g4 407 5 have have VB cord-354029-mp5r82g4 407 6 a a DT cord-354029-mp5r82g4 407 7 high high JJ cord-354029-mp5r82g4 407 8 proportion proportion NN cord-354029-mp5r82g4 407 9 of of IN cord-354029-mp5r82g4 407 10 tryptophans tryptophan NNS cord-354029-mp5r82g4 407 11 or or CC cord-354029-mp5r82g4 407 12 other other JJ cord-354029-mp5r82g4 407 13 aromatic aromatic JJ cord-354029-mp5r82g4 407 14 residues residue NNS cord-354029-mp5r82g4 407 15 and and CC cord-354029-mp5r82g4 407 16 are be VBP cord-354029-mp5r82g4 407 17 predicted predict VBN cord-354029-mp5r82g4 407 18 to to TO cord-354029-mp5r82g4 407 19 partition partition VB cord-354029-mp5r82g4 407 20 into into IN cord-354029-mp5r82g4 407 21 the the DT cord-354029-mp5r82g4 407 22 interfacial interfacial JJ cord-354029-mp5r82g4 407 23 regions region NNS cord-354029-mp5r82g4 407 24 of of IN cord-354029-mp5r82g4 407 25 membranes membrane NNS cord-354029-mp5r82g4 408 1 ( ( -LRB- cord-354029-mp5r82g4 408 2 Suarez Suarez NNP cord-354029-mp5r82g4 408 3 et et NNP cord-354029-mp5r82g4 408 4 al al NNP cord-354029-mp5r82g4 408 5 . . . cord-354029-mp5r82g4 408 6 2000 2000 CD cord-354029-mp5r82g4 408 7 ) ) -RRB- cord-354029-mp5r82g4 408 8 . . . cord-354029-mp5r82g4 409 1 Indeed indeed RB cord-354029-mp5r82g4 409 2 , , , cord-354029-mp5r82g4 409 3 synthetic synthetic JJ cord-354029-mp5r82g4 409 4 peptides peptide NNS cord-354029-mp5r82g4 409 5 containing contain VBG cord-354029-mp5r82g4 409 6 juxtamembrane juxtamembrane NNP cord-354029-mp5r82g4 409 7 ectodomain ectodomain NNP cord-354029-mp5r82g4 409 8 sequences sequence NNS cord-354029-mp5r82g4 409 9 from from IN cord-354029-mp5r82g4 409 10 HIV HIV NNP cord-354029-mp5r82g4 409 11 Env Env NNP cord-354029-mp5r82g4 409 12 and and CC cord-354029-mp5r82g4 409 13 Ebola Ebola NNP cord-354029-mp5r82g4 409 14 GP GP NNP cord-354029-mp5r82g4 409 15 partition partition NN cord-354029-mp5r82g4 409 16 into into IN cord-354029-mp5r82g4 409 17 the the DT cord-354029-mp5r82g4 409 18 interfacial interfacial JJ cord-354029-mp5r82g4 409 19 region region NN cord-354029-mp5r82g4 409 20 of of IN cord-354029-mp5r82g4 409 21 target target NN cord-354029-mp5r82g4 409 22 membranes membrane NNS cord-354029-mp5r82g4 409 23 ( ( -LRB- cord-354029-mp5r82g4 409 24 Saez Saez NNP cord-354029-mp5r82g4 409 25 - - HYPH cord-354029-mp5r82g4 409 26 Cirion Cirion NNP cord-354029-mp5r82g4 409 27 et et NNP cord-354029-mp5r82g4 409 28 al al NNP cord-354029-mp5r82g4 409 29 . . . cord-354029-mp5r82g4 410 1 2003 2003 CD cord-354029-mp5r82g4 410 2 ; ; : cord-354029-mp5r82g4 410 3 Saez Saez NNP cord-354029-mp5r82g4 410 4 - - HYPH cord-354029-mp5r82g4 410 5 Cirion Cirion NNP cord-354029-mp5r82g4 410 6 et et NNP cord-354029-mp5r82g4 410 7 al al NNP cord-354029-mp5r82g4 410 8 . . . cord-354029-mp5r82g4 410 9 2002 2002 CD cord-354029-mp5r82g4 411 1 ; ; : cord-354029-mp5r82g4 411 2 Schibli Schibli NNP cord-354029-mp5r82g4 411 3 et et NNP cord-354029-mp5r82g4 411 4 al al NNP cord-354029-mp5r82g4 411 5 . . . cord-354029-mp5r82g4 412 1 2001 2001 CD cord-354029-mp5r82g4 412 2 ; ; : cord-354029-mp5r82g4 412 3 Suarez Suarez NNP cord-354029-mp5r82g4 412 4 et et NNP cord-354029-mp5r82g4 412 5 al al NNP cord-354029-mp5r82g4 412 6 . . . cord-354029-mp5r82g4 412 7 2000 2000 CD cord-354029-mp5r82g4 412 8 ) ) -RRB- cord-354029-mp5r82g4 412 9 . . . cord-354029-mp5r82g4 413 1 Mutation mutation NN cord-354029-mp5r82g4 413 2 of of IN cord-354029-mp5r82g4 413 3 three three CD cord-354029-mp5r82g4 413 4 tryptophans tryptophan NNS cord-354029-mp5r82g4 413 5 within within IN cord-354029-mp5r82g4 413 6 this this DT cord-354029-mp5r82g4 413 7 region region NN cord-354029-mp5r82g4 413 8 of of IN cord-354029-mp5r82g4 413 9 HIV HIV NNP cord-354029-mp5r82g4 413 10 gp41 gp41 NNP cord-354029-mp5r82g4 413 11 abrogated abrogate VBD cord-354029-mp5r82g4 413 12 infection infection NN cord-354029-mp5r82g4 413 13 ) ) -RRB- cord-354029-mp5r82g4 413 14 , , , cord-354029-mp5r82g4 413 15 apparently apparently RB cord-354029-mp5r82g4 413 16 by by IN cord-354029-mp5r82g4 413 17 inhibiting inhibit VBG cord-354029-mp5r82g4 413 18 fusion fusion NN cord-354029-mp5r82g4 413 19 pore pore NN cord-354029-mp5r82g4 413 20 enlargement enlargement NN cord-354029-mp5r82g4 413 21 ( ( -LRB- cord-354029-mp5r82g4 413 22 Munoz Munoz NNP cord-354029-mp5r82g4 413 23 - - HYPH cord-354029-mp5r82g4 413 24 Barroso Barroso NNP cord-354029-mp5r82g4 413 25 et et NNP cord-354029-mp5r82g4 413 26 al al NNP cord-354029-mp5r82g4 413 27 . . . cord-354029-mp5r82g4 413 28 1999 1999 CD cord-354029-mp5r82g4 413 29 ) ) -RRB- cord-354029-mp5r82g4 413 30 . . . cord-354029-mp5r82g4 414 1 Extending extend VBG cord-354029-mp5r82g4 414 2 the the DT cord-354029-mp5r82g4 414 3 HIV HIV NNP cord-354029-mp5r82g4 414 4 gp41 gp41 NNP cord-354029-mp5r82g4 414 5 C C NNP cord-354029-mp5r82g4 414 6 - - HYPH cord-354029-mp5r82g4 414 7 terminal terminal NN cord-354029-mp5r82g4 414 8 heptad heptad NNP cord-354029-mp5r82g4 414 9 repeat repeat NN cord-354029-mp5r82g4 414 10 peptide peptide JJ cord-354029-mp5r82g4 414 11 to to TO cord-354029-mp5r82g4 414 12 include include VB cord-354029-mp5r82g4 414 13 the the DT cord-354029-mp5r82g4 414 14 tryptophan tryptophan NN cord-354029-mp5r82g4 414 15 - - HYPH cord-354029-mp5r82g4 414 16 rich rich JJ cord-354029-mp5r82g4 414 17 juxtamembrane juxtamembrane NNP cord-354029-mp5r82g4 414 18 ectodomain ectodomain NNP cord-354029-mp5r82g4 414 19 sequence sequence NN cord-354029-mp5r82g4 414 20 appeared appear VBD cord-354029-mp5r82g4 414 21 to to TO cord-354029-mp5r82g4 414 22 increase increase VB cord-354029-mp5r82g4 414 23 the the DT cord-354029-mp5r82g4 414 24 potency potency NN cord-354029-mp5r82g4 414 25 of of IN cord-354029-mp5r82g4 414 26 the the DT cord-354029-mp5r82g4 414 27 peptide peptide NN cord-354029-mp5r82g4 414 28 as as IN cord-354029-mp5r82g4 414 29 an an DT cord-354029-mp5r82g4 414 30 inhibitor inhibitor NN cord-354029-mp5r82g4 414 31 of of IN cord-354029-mp5r82g4 414 32 fusion fusion NN cord-354029-mp5r82g4 414 33 ( ( -LRB- cord-354029-mp5r82g4 414 34 Kliger Kliger NNP cord-354029-mp5r82g4 414 35 et et NNP cord-354029-mp5r82g4 414 36 al al NNP cord-354029-mp5r82g4 414 37 . . NNP cord-354029-mp5r82g4 414 38 2001 2001 CD cord-354029-mp5r82g4 414 39 ) ) -RRB- cord-354029-mp5r82g4 414 40 . . . cord-354029-mp5r82g4 415 1 It -PRON- PRP cord-354029-mp5r82g4 415 2 was be VBD cord-354029-mp5r82g4 415 3 suggested suggest VBN cord-354029-mp5r82g4 415 4 that that IN cord-354029-mp5r82g4 415 5 the the DT cord-354029-mp5r82g4 415 6 extended extend VBN cord-354029-mp5r82g4 415 7 heptad heptad NN cord-354029-mp5r82g4 415 8 repeat repeat NN cord-354029-mp5r82g4 415 9 peptide peptide NN cord-354029-mp5r82g4 415 10 was be VBD cord-354029-mp5r82g4 415 11 more more RBR cord-354029-mp5r82g4 415 12 potent potent JJ cord-354029-mp5r82g4 415 13 because because IN cord-354029-mp5r82g4 415 14 it -PRON- PRP cord-354029-mp5r82g4 415 15 could could MD cord-354029-mp5r82g4 415 16 bind bind VB cord-354029-mp5r82g4 415 17 to to IN cord-354029-mp5r82g4 415 18 two two CD cord-354029-mp5r82g4 415 19 sites site NNS cord-354029-mp5r82g4 415 20 on on IN cord-354029-mp5r82g4 415 21 HIV HIV NNP cord-354029-mp5r82g4 415 22 Env Env NNP cord-354029-mp5r82g4 415 23 ( ( -LRB- cord-354029-mp5r82g4 415 24 the the DT cord-354029-mp5r82g4 415 25 N n CD cord-354029-mp5r82g4 415 26 - - HYPH cord-354029-mp5r82g4 415 27 terminal terminal NN cord-354029-mp5r82g4 415 28 coiled coil VBN cord-354029-mp5r82g4 415 29 - - HYPH cord-354029-mp5r82g4 415 30 coil coil NN cord-354029-mp5r82g4 415 31 and and CC cord-354029-mp5r82g4 415 32 a a DT cord-354029-mp5r82g4 415 33 second second NN cord-354029-mp5r82g4 415 34 , , , cord-354029-mp5r82g4 415 35 as as RB cord-354029-mp5r82g4 415 36 yet yet RB cord-354029-mp5r82g4 415 37 unidentified unidentified JJ cord-354029-mp5r82g4 415 38 site site NN cord-354029-mp5r82g4 415 39 ) ) -RRB- cord-354029-mp5r82g4 416 1 ( ( -LRB- cord-354029-mp5r82g4 416 2 Kliger Kliger NNP cord-354029-mp5r82g4 416 3 et et NNP cord-354029-mp5r82g4 416 4 al al NNP cord-354029-mp5r82g4 416 5 . . NNP cord-354029-mp5r82g4 416 6 2001 2001 CD cord-354029-mp5r82g4 416 7 ) ) -RRB- cord-354029-mp5r82g4 416 8 . . . cord-354029-mp5r82g4 417 1 A a DT cord-354029-mp5r82g4 417 2 likely likely JJ cord-354029-mp5r82g4 417 3 effect effect NN cord-354029-mp5r82g4 417 4 of of IN cord-354029-mp5r82g4 417 5 these these DT cord-354029-mp5r82g4 417 6 peptides peptide NNS cord-354029-mp5r82g4 417 7 on on IN cord-354029-mp5r82g4 417 8 late late JJ cord-354029-mp5r82g4 417 9 stages stage NNS cord-354029-mp5r82g4 417 10 of of IN cord-354029-mp5r82g4 417 11 fusion fusion NN cord-354029-mp5r82g4 417 12 is be VBZ cord-354029-mp5r82g4 417 13 to to TO cord-354029-mp5r82g4 417 14 prevent prevent VB cord-354029-mp5r82g4 417 15 formation formation NN cord-354029-mp5r82g4 417 16 of of IN cord-354029-mp5r82g4 417 17 a a DT cord-354029-mp5r82g4 417 18 required require VBN cord-354029-mp5r82g4 417 19 structure structure NN cord-354029-mp5r82g4 417 20 in in IN cord-354029-mp5r82g4 417 21 Env Env NNP cord-354029-mp5r82g4 417 22 that that WDT cord-354029-mp5r82g4 417 23 provides provide VBZ cord-354029-mp5r82g4 417 24 additional additional JJ cord-354029-mp5r82g4 417 25 membrane membrane NN cord-354029-mp5r82g4 417 26 destabilization destabilization NN cord-354029-mp5r82g4 417 27 . . . cord-354029-mp5r82g4 418 1 In in IN cord-354029-mp5r82g4 418 2 this this DT cord-354029-mp5r82g4 418 3 manner manner NN cord-354029-mp5r82g4 418 4 , , , cord-354029-mp5r82g4 418 5 partitioning partitioning NN cord-354029-mp5r82g4 418 6 of of IN cord-354029-mp5r82g4 418 7 juxtamembrane juxtamembrane NNP cord-354029-mp5r82g4 418 8 sequences sequence NNS cord-354029-mp5r82g4 418 9 into into IN cord-354029-mp5r82g4 418 10 the the DT cord-354029-mp5r82g4 418 11 interfacial interfacial JJ cord-354029-mp5r82g4 418 12 region region NN cord-354029-mp5r82g4 418 13 of of IN cord-354029-mp5r82g4 418 14 membranes membrane NNS cord-354029-mp5r82g4 418 15 may may MD cord-354029-mp5r82g4 418 16 promote promote VB cord-354029-mp5r82g4 418 17 the the DT cord-354029-mp5r82g4 418 18 transition transition NN cord-354029-mp5r82g4 418 19 from from IN cord-354029-mp5r82g4 418 20 a a DT cord-354029-mp5r82g4 418 21 stalk stalk NN cord-354029-mp5r82g4 418 22 intermediate intermediate JJ cord-354029-mp5r82g4 418 23 to to IN cord-354029-mp5r82g4 418 24 a a DT cord-354029-mp5r82g4 418 25 fusion fusion NN cord-354029-mp5r82g4 418 26 pore pore NN cord-354029-mp5r82g4 418 27 ( ( -LRB- cord-354029-mp5r82g4 418 28 see see VB cord-354029-mp5r82g4 418 29 Sect Sect NNP cord-354029-mp5r82g4 418 30 . . . cord-354029-mp5r82g4 419 1 5 5 LS cord-354029-mp5r82g4 419 2 ) ) -RRB- cord-354029-mp5r82g4 419 3 . . . cord-354029-mp5r82g4 420 1 A a DT cord-354029-mp5r82g4 420 2 specific specific JJ cord-354029-mp5r82g4 420 3 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 420 4 tail tail NN cord-354029-mp5r82g4 420 5 sequence sequence NN cord-354029-mp5r82g4 420 6 does do VBZ cord-354029-mp5r82g4 420 7 not not RB cord-354029-mp5r82g4 420 8 appear appear VB cord-354029-mp5r82g4 420 9 to to TO cord-354029-mp5r82g4 420 10 be be VB cord-354029-mp5r82g4 420 11 essential essential JJ cord-354029-mp5r82g4 420 12 , , , cord-354029-mp5r82g4 420 13 but but CC cord-354029-mp5r82g4 420 14 it -PRON- PRP cord-354029-mp5r82g4 420 15 can can MD cord-354029-mp5r82g4 420 16 modulate modulate VB cord-354029-mp5r82g4 420 17 late late JJ cord-354029-mp5r82g4 420 18 stages stage NNS cord-354029-mp5r82g4 420 19 of of IN cord-354029-mp5r82g4 420 20 fusion fusion NN cord-354029-mp5r82g4 420 21 . . . cord-354029-mp5r82g4 421 1 The the DT cord-354029-mp5r82g4 421 2 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 421 3 tail tail NN cord-354029-mp5r82g4 421 4 has have VBZ cord-354029-mp5r82g4 421 5 been be VBN cord-354029-mp5r82g4 421 6 shown show VBN cord-354029-mp5r82g4 421 7 to to TO cord-354029-mp5r82g4 421 8 influence influence VB cord-354029-mp5r82g4 421 9 the the DT cord-354029-mp5r82g4 421 10 transition transition NN cord-354029-mp5r82g4 421 11 from from IN cord-354029-mp5r82g4 421 12 hemifusion hemifusion NN cord-354029-mp5r82g4 421 13 to to IN cord-354029-mp5r82g4 421 14 full full JJ cord-354029-mp5r82g4 421 15 fusion fusion NN cord-354029-mp5r82g4 421 16 or or CC cord-354029-mp5r82g4 421 17 fusion fusion NN cord-354029-mp5r82g4 421 18 pore pore NN cord-354029-mp5r82g4 421 19 enlargement enlargement NN cord-354029-mp5r82g4 421 20 ( ( -LRB- cord-354029-mp5r82g4 421 21 Dutch Dutch NNP cord-354029-mp5r82g4 421 22 and and CC cord-354029-mp5r82g4 421 23 Lamb Lamb NNP cord-354029-mp5r82g4 421 24 2001 2001 CD cord-354029-mp5r82g4 421 25 ; ; : cord-354029-mp5r82g4 421 26 Kozerski Kozerski NNP cord-354029-mp5r82g4 421 27 et et NNP cord-354029-mp5r82g4 421 28 al al NNP cord-354029-mp5r82g4 421 29 . . . cord-354029-mp5r82g4 421 30 2000 2000 CD cord-354029-mp5r82g4 421 31 ) ) -RRB- cord-354029-mp5r82g4 421 32 in in IN cord-354029-mp5r82g4 421 33 some some DT cord-354029-mp5r82g4 421 34 viruses virus NNS cord-354029-mp5r82g4 421 35 . . . cord-354029-mp5r82g4 422 1 The the DT cord-354029-mp5r82g4 422 2 mechanism mechanism NN cord-354029-mp5r82g4 422 3 by by IN cord-354029-mp5r82g4 422 4 which which WDT cord-354029-mp5r82g4 422 5 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 422 6 tails tail NNS cord-354029-mp5r82g4 422 7 may may MD cord-354029-mp5r82g4 422 8 influence influence VB cord-354029-mp5r82g4 422 9 these these DT cord-354029-mp5r82g4 422 10 later later JJ cord-354029-mp5r82g4 422 11 stages stage NNS cord-354029-mp5r82g4 422 12 of of IN cord-354029-mp5r82g4 422 13 fusion fusion NN cord-354029-mp5r82g4 422 14 is be VBZ cord-354029-mp5r82g4 422 15 not not RB cord-354029-mp5r82g4 422 16 known know VBN cord-354029-mp5r82g4 422 17 . . . cord-354029-mp5r82g4 423 1 Some some DT cord-354029-mp5r82g4 423 2 studies study NNS cord-354029-mp5r82g4 423 3 using use VBG cord-354029-mp5r82g4 423 4 synthetic synthetic JJ cord-354029-mp5r82g4 423 5 peptides peptide NNS cord-354029-mp5r82g4 423 6 have have VBP cord-354029-mp5r82g4 423 7 suggested suggest VBN cord-354029-mp5r82g4 423 8 a a DT cord-354029-mp5r82g4 423 9 direct direct JJ cord-354029-mp5r82g4 423 10 interaction interaction NN cord-354029-mp5r82g4 423 11 between between IN cord-354029-mp5r82g4 423 12 the the DT cord-354029-mp5r82g4 423 13 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 423 14 tail tail NN cord-354029-mp5r82g4 423 15 and and CC cord-354029-mp5r82g4 423 16 the the DT cord-354029-mp5r82g4 423 17 viral viral JJ cord-354029-mp5r82g4 423 18 membrane membrane NN cord-354029-mp5r82g4 423 19 ( ( -LRB- cord-354029-mp5r82g4 423 20 Chen Chen NNP cord-354029-mp5r82g4 423 21 et et NNP cord-354029-mp5r82g4 423 22 al al NNP cord-354029-mp5r82g4 423 23 . . . cord-354029-mp5r82g4 424 1 2001b 2001b CD cord-354029-mp5r82g4 424 2 ; ; : cord-354029-mp5r82g4 424 3 Fujii Fujii NNP cord-354029-mp5r82g4 424 4 et et NNP cord-354029-mp5r82g4 424 5 al al NNP cord-354029-mp5r82g4 424 6 . . . cord-354029-mp5r82g4 424 7 1992 1992 CD cord-354029-mp5r82g4 425 1 ; ; : cord-354029-mp5r82g4 425 2 Gawrisch Gawrisch NNP cord-354029-mp5r82g4 425 3 et et NNP cord-354029-mp5r82g4 425 4 al al NNP cord-354029-mp5r82g4 425 5 . . NNP cord-354029-mp5r82g4 425 6 1993 1993 CD cord-354029-mp5r82g4 425 7 ; ; : cord-354029-mp5r82g4 425 8 Haffar Haffar NNP cord-354029-mp5r82g4 425 9 et et NNP cord-354029-mp5r82g4 425 10 al al NNP cord-354029-mp5r82g4 425 11 . . . cord-354029-mp5r82g4 426 1 1991 1991 CD cord-354029-mp5r82g4 426 2 ; ; : cord-354029-mp5r82g4 426 3 . . . cord-354029-mp5r82g4 427 1 Others other NNS cord-354029-mp5r82g4 427 2 have have VBP cord-354029-mp5r82g4 427 3 shown show VBN cord-354029-mp5r82g4 427 4 that that IN cord-354029-mp5r82g4 427 5 the the DT cord-354029-mp5r82g4 427 6 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 427 7 tail tail NN cord-354029-mp5r82g4 427 8 can can MD cord-354029-mp5r82g4 427 9 influence influence VB cord-354029-mp5r82g4 427 10 the the DT cord-354029-mp5r82g4 427 11 structure structure NN cord-354029-mp5r82g4 427 12 of of IN cord-354029-mp5r82g4 427 13 the the DT cord-354029-mp5r82g4 427 14 ectodomain ectodomain NN cord-354029-mp5r82g4 427 15 of of IN cord-354029-mp5r82g4 427 16 the the DT cord-354029-mp5r82g4 427 17 fusion fusion NN cord-354029-mp5r82g4 427 18 protein protein NN cord-354029-mp5r82g4 427 19 ( ( -LRB- cord-354029-mp5r82g4 427 20 Aguilar Aguilar NNP cord-354029-mp5r82g4 427 21 et et NNP cord-354029-mp5r82g4 427 22 al al NNP cord-354029-mp5r82g4 427 23 . . NNP cord-354029-mp5r82g4 427 24 2003 2003 CD cord-354029-mp5r82g4 427 25 ; ; : cord-354029-mp5r82g4 427 26 Edwards Edwards NNP cord-354029-mp5r82g4 427 27 et et NNP cord-354029-mp5r82g4 427 28 al al NNP cord-354029-mp5r82g4 427 29 . . . cord-354029-mp5r82g4 427 30 2002 2002 CD cord-354029-mp5r82g4 427 31 ) ) -RRB- cord-354029-mp5r82g4 427 32 . . . cord-354029-mp5r82g4 428 1 The the DT cord-354029-mp5r82g4 428 2 ability ability NN cord-354029-mp5r82g4 428 3 of of IN cord-354029-mp5r82g4 428 4 the the DT cord-354029-mp5r82g4 428 5 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 428 6 tail tail NN cord-354029-mp5r82g4 428 7 to to TO cord-354029-mp5r82g4 428 8 affect affect VB cord-354029-mp5r82g4 428 9 ectodomain ectodomain JJ cord-354029-mp5r82g4 428 10 structure structure NN cord-354029-mp5r82g4 428 11 is be VBZ cord-354029-mp5r82g4 428 12 most most RBS cord-354029-mp5r82g4 428 13 clearly clearly RB cord-354029-mp5r82g4 428 14 manifested manifest VBN cord-354029-mp5r82g4 428 15 for for IN cord-354029-mp5r82g4 428 16 those those DT cord-354029-mp5r82g4 428 17 viral viral JJ cord-354029-mp5r82g4 428 18 fusion fusion NN cord-354029-mp5r82g4 428 19 proteins protein NNS cord-354029-mp5r82g4 428 20 that that WDT cord-354029-mp5r82g4 428 21 harbor harbor VBP cord-354029-mp5r82g4 428 22 fusion fusion NN cord-354029-mp5r82g4 428 23 - - HYPH cord-354029-mp5r82g4 428 24 suppressing suppress VBG cord-354029-mp5r82g4 428 25 sequences sequence NNS cord-354029-mp5r82g4 428 26 . . . cord-354029-mp5r82g4 429 1 These these DT cord-354029-mp5r82g4 429 2 sequences sequence NNS cord-354029-mp5r82g4 429 3 have have VBP cord-354029-mp5r82g4 429 4 been be VBN cord-354029-mp5r82g4 429 5 found find VBN cord-354029-mp5r82g4 429 6 in in IN cord-354029-mp5r82g4 429 7 the the DT cord-354029-mp5r82g4 429 8 fusion fusion NN cord-354029-mp5r82g4 429 9 proteins protein NNS cord-354029-mp5r82g4 429 10 of of IN cord-354029-mp5r82g4 429 11 MLV MLV NNP cord-354029-mp5r82g4 429 12 ( ( -LRB- cord-354029-mp5r82g4 429 13 Ragheb Ragheb NNP cord-354029-mp5r82g4 429 14 and and CC cord-354029-mp5r82g4 429 15 Anderson Anderson NNP cord-354029-mp5r82g4 429 16 1994 1994 CD cord-354029-mp5r82g4 429 17 ) ) -RRB- cord-354029-mp5r82g4 429 18 , , , cord-354029-mp5r82g4 429 19 other other JJ cord-354029-mp5r82g4 429 20 type type NN cord-354029-mp5r82g4 429 21 C c NN cord-354029-mp5r82g4 429 22 retroviruses retrovirus NNS cord-354029-mp5r82g4 429 23 ( ( -LRB- cord-354029-mp5r82g4 429 24 Bobkova Bobkova NNP cord-354029-mp5r82g4 429 25 et et NNP cord-354029-mp5r82g4 429 26 al al NNP cord-354029-mp5r82g4 429 27 . . . cord-354029-mp5r82g4 429 28 2002 2002 CD cord-354029-mp5r82g4 429 29 ) ) -RRB- cord-354029-mp5r82g4 429 30 , , , cord-354029-mp5r82g4 429 31 some some DT cord-354029-mp5r82g4 429 32 lentiviruses lentiviruse NNS cord-354029-mp5r82g4 429 33 ( ( -LRB- cord-354029-mp5r82g4 429 34 Kim Kim NNP cord-354029-mp5r82g4 429 35 et et NNP cord-354029-mp5r82g4 429 36 al al NNP cord-354029-mp5r82g4 429 37 . . NNP cord-354029-mp5r82g4 429 38 2003 2003 CD cord-354029-mp5r82g4 429 39 ; ; : cord-354029-mp5r82g4 429 40 Luciw Luciw NNP cord-354029-mp5r82g4 429 41 et et NNP cord-354029-mp5r82g4 429 42 al al NNP cord-354029-mp5r82g4 429 43 . . . cord-354029-mp5r82g4 429 44 1998 1998 CD cord-354029-mp5r82g4 429 45 ) ) -RRB- cord-354029-mp5r82g4 429 46 , , , cord-354029-mp5r82g4 429 47 and and CC cord-354029-mp5r82g4 429 48 a a DT cord-354029-mp5r82g4 429 49 paramyxovirus paramyxovirus JJ cord-354029-mp5r82g4 429 50 F F NNP cord-354029-mp5r82g4 429 51 protein protein NN cord-354029-mp5r82g4 429 52 ( ( -LRB- cord-354029-mp5r82g4 429 53 Tong Tong NNP cord-354029-mp5r82g4 429 54 et et NNP cord-354029-mp5r82g4 429 55 al al NNP cord-354029-mp5r82g4 429 56 . . . cord-354029-mp5r82g4 429 57 2002 2002 CD cord-354029-mp5r82g4 429 58 ) ) -RRB- cord-354029-mp5r82g4 429 59 . . . cord-354029-mp5r82g4 430 1 The the DT cord-354029-mp5r82g4 430 2 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 430 3 tail tail NN cord-354029-mp5r82g4 430 4 of of IN cord-354029-mp5r82g4 430 5 MLV MLV NNP cord-354029-mp5r82g4 430 6 Env Env NNP cord-354029-mp5r82g4 430 7 is be VBZ cord-354029-mp5r82g4 430 8 cleaved cleave VBN cord-354029-mp5r82g4 430 9 during during IN cord-354029-mp5r82g4 430 10 virus virus NN cord-354029-mp5r82g4 430 11 budding bud VBG cord-354029-mp5r82g4 430 12 ( ( -LRB- cord-354029-mp5r82g4 430 13 Schultz Schultz NNP cord-354029-mp5r82g4 430 14 and and CC cord-354029-mp5r82g4 430 15 Rein Rein NNP cord-354029-mp5r82g4 430 16 1985 1985 CD cord-354029-mp5r82g4 430 17 ) ) -RRB- cord-354029-mp5r82g4 430 18 . . . cord-354029-mp5r82g4 431 1 MLV MLV NNP cord-354029-mp5r82g4 431 2 Envs Envs NNP cord-354029-mp5r82g4 431 3 harboring harbor VBG cord-354029-mp5r82g4 431 4 uncleaved uncleaved JJ cord-354029-mp5r82g4 431 5 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 431 6 tails tail NNS cord-354029-mp5r82g4 431 7 do do VBP cord-354029-mp5r82g4 431 8 not not RB cord-354029-mp5r82g4 431 9 induce induce VB cord-354029-mp5r82g4 431 10 fusion fusion NN cord-354029-mp5r82g4 431 11 ( ( -LRB- cord-354029-mp5r82g4 431 12 Yang Yang NNP cord-354029-mp5r82g4 431 13 and and CC cord-354029-mp5r82g4 431 14 Compans Compans NNP cord-354029-mp5r82g4 431 15 1996 1996 CD cord-354029-mp5r82g4 431 16 ) ) -RRB- cord-354029-mp5r82g4 431 17 . . . cord-354029-mp5r82g4 432 1 Although although IN cord-354029-mp5r82g4 432 2 viruses virus NNS cord-354029-mp5r82g4 432 3 lacking lack VBG cord-354029-mp5r82g4 432 4 fusion fusion NN cord-354029-mp5r82g4 432 5 - - HYPH cord-354029-mp5r82g4 432 6 suppressing suppress VBG cord-354029-mp5r82g4 432 7 sequences sequence NNS cord-354029-mp5r82g4 432 8 display display VBP cord-354029-mp5r82g4 432 9 increased increase VBN cord-354029-mp5r82g4 432 10 cell cell NN cord-354029-mp5r82g4 432 11 - - HYPH cord-354029-mp5r82g4 432 12 cell cell NN cord-354029-mp5r82g4 432 13 fusion fusion NN cord-354029-mp5r82g4 432 14 , , , cord-354029-mp5r82g4 432 15 they -PRON- PRP cord-354029-mp5r82g4 432 16 are be VBP cord-354029-mp5r82g4 432 17 more more RBR cord-354029-mp5r82g4 432 18 susceptible susceptible JJ cord-354029-mp5r82g4 432 19 to to IN cord-354029-mp5r82g4 432 20 neutralizing neutralize VBG cord-354029-mp5r82g4 432 21 antibodies antibody NNS cord-354029-mp5r82g4 432 22 ( ( -LRB- cord-354029-mp5r82g4 432 23 Januszeski Januszeski NNP cord-354029-mp5r82g4 432 24 et et NNP cord-354029-mp5r82g4 432 25 al al NNP cord-354029-mp5r82g4 432 26 . . . cord-354029-mp5r82g4 432 27 1997 1997 CD cord-354029-mp5r82g4 432 28 ; ; . cord-354029-mp5r82g4 433 1 Li Li NNP cord-354029-mp5r82g4 433 2 et et NNP cord-354029-mp5r82g4 433 3 al al NNP cord-354029-mp5r82g4 433 4 . . . cord-354029-mp5r82g4 434 1 2001 2001 CD cord-354029-mp5r82g4 434 2 ; ; : cord-354029-mp5r82g4 434 3 Rein Rein NNP cord-354029-mp5r82g4 434 4 et et FW cord-354029-mp5r82g4 434 5 al al NNP cord-354029-mp5r82g4 434 6 . . . cord-354029-mp5r82g4 434 7 1994 1994 CD cord-354029-mp5r82g4 434 8 ; ; . cord-354029-mp5r82g4 435 1 Yang Yang NNP cord-354029-mp5r82g4 435 2 and and CC cord-354029-mp5r82g4 435 3 Compans Compans NNP cord-354029-mp5r82g4 435 4 1996 1996 CD cord-354029-mp5r82g4 435 5 ) ) -RRB- cord-354029-mp5r82g4 435 6 and and CC cord-354029-mp5r82g4 435 7 are be VBP cord-354029-mp5r82g4 435 8 impaired impair VBN cord-354029-mp5r82g4 435 9 in in IN cord-354029-mp5r82g4 435 10 their -PRON- PRP$ cord-354029-mp5r82g4 435 11 ability ability NN cord-354029-mp5r82g4 435 12 to to TO cord-354029-mp5r82g4 435 13 sustain sustain VB cord-354029-mp5r82g4 435 14 multiple multiple JJ cord-354029-mp5r82g4 435 15 rounds round NNS cord-354029-mp5r82g4 435 16 of of IN cord-354029-mp5r82g4 435 17 infection infection NN cord-354029-mp5r82g4 436 1 ( ( -LRB- cord-354029-mp5r82g4 436 2 Cathomen Cathomen NNP cord-354029-mp5r82g4 436 3 et et FW cord-354029-mp5r82g4 436 4 al al NNP cord-354029-mp5r82g4 436 5 . . . cord-354029-mp5r82g4 437 1 1998 1998 CD cord-354029-mp5r82g4 437 2 ; ; : cord-354029-mp5r82g4 437 3 Freed Freed NNP cord-354029-mp5r82g4 437 4 and and CC cord-354029-mp5r82g4 437 5 Martin Martin NNP cord-354029-mp5r82g4 437 6 1996 1996 CD cord-354029-mp5r82g4 437 7 ; ; : cord-354029-mp5r82g4 437 8 Piller Piller NNP cord-354029-mp5r82g4 437 9 et et NNP cord-354029-mp5r82g4 437 10 al al NNP cord-354029-mp5r82g4 437 11 . . . cord-354029-mp5r82g4 437 12 2000 2000 CD cord-354029-mp5r82g4 437 13 ) ) -RRB- cord-354029-mp5r82g4 437 14 . . . cord-354029-mp5r82g4 438 1 Acylation acylation NN cord-354029-mp5r82g4 438 2 of of IN cord-354029-mp5r82g4 438 3 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 438 4 tails tail NNS cord-354029-mp5r82g4 438 5 can can MD cord-354029-mp5r82g4 438 6 also also RB cord-354029-mp5r82g4 438 7 affect affect VB cord-354029-mp5r82g4 438 8 fusion fusion NN cord-354029-mp5r82g4 438 9 , , , cord-354029-mp5r82g4 438 10 apparently apparently RB cord-354029-mp5r82g4 438 11 at at IN cord-354029-mp5r82g4 438 12 a a DT cord-354029-mp5r82g4 438 13 late late JJ cord-354029-mp5r82g4 438 14 stage stage NN cord-354029-mp5r82g4 438 15 . . . cord-354029-mp5r82g4 439 1 For for IN cord-354029-mp5r82g4 439 2 example example NN cord-354029-mp5r82g4 439 3 , , , cord-354029-mp5r82g4 439 4 a a DT cord-354029-mp5r82g4 439 5 mutant mutant JJ cord-354029-mp5r82g4 439 6 HA HA NNP cord-354029-mp5r82g4 439 7 from from IN cord-354029-mp5r82g4 439 8 the the DT cord-354029-mp5r82g4 439 9 Japan Japan NNP cord-354029-mp5r82g4 439 10 strain strain NN cord-354029-mp5r82g4 439 11 of of IN cord-354029-mp5r82g4 439 12 influenza influenza NN cord-354029-mp5r82g4 439 13 in in IN cord-354029-mp5r82g4 439 14 which which WDT cord-354029-mp5r82g4 439 15 three three CD cord-354029-mp5r82g4 439 16 ( ( -LRB- cord-354029-mp5r82g4 439 17 normally normally RB cord-354029-mp5r82g4 439 18 palmitoylated palmitoylated JJ cord-354029-mp5r82g4 439 19 ) ) -RRB- cord-354029-mp5r82g4 439 20 cysteine cysteine NN cord-354029-mp5r82g4 439 21 residues residue NNS cord-354029-mp5r82g4 439 22 were be VBD cord-354029-mp5r82g4 439 23 mutated mutate VBN cord-354029-mp5r82g4 439 24 appeared appear VBD cord-354029-mp5r82g4 439 25 to to TO cord-354029-mp5r82g4 439 26 fuse fuse VB cord-354029-mp5r82g4 439 27 normally normally RB cord-354029-mp5r82g4 439 28 when when WRB cord-354029-mp5r82g4 439 29 monitored monitor VBN cord-354029-mp5r82g4 439 30 by by IN cord-354029-mp5r82g4 439 31 dye dye NN cord-354029-mp5r82g4 439 32 redistribution redistribution NN cord-354029-mp5r82g4 439 33 assays assay NNS cord-354029-mp5r82g4 439 34 ( ( -LRB- cord-354029-mp5r82g4 439 35 Melikyan Melikyan NNP cord-354029-mp5r82g4 439 36 et et NNP cord-354029-mp5r82g4 439 37 al al NNP cord-354029-mp5r82g4 439 38 . . NNP cord-354029-mp5r82g4 439 39 1997b 1997b CD cord-354029-mp5r82g4 439 40 ) ) -RRB- cord-354029-mp5r82g4 439 41 . . . cord-354029-mp5r82g4 440 1 However however RB cord-354029-mp5r82g4 440 2 , , , cord-354029-mp5r82g4 440 3 electrophysiological electrophysiological JJ cord-354029-mp5r82g4 440 4 measurements measurement NNS cord-354029-mp5r82g4 440 5 revealed reveal VBD cord-354029-mp5r82g4 440 6 that that IN cord-354029-mp5r82g4 440 7 fusion fusion NN cord-354029-mp5r82g4 440 8 pores pore NNS cord-354029-mp5r82g4 440 9 formed form VBN cord-354029-mp5r82g4 440 10 by by IN cord-354029-mp5r82g4 440 11 the the DT cord-354029-mp5r82g4 440 12 mutant mutant JJ cord-354029-mp5r82g4 440 13 HA HA NNP cord-354029-mp5r82g4 440 14 did do VBD cord-354029-mp5r82g4 440 15 not not RB cord-354029-mp5r82g4 440 16 flicker flicker VB cord-354029-mp5r82g4 440 17 like like IN cord-354029-mp5r82g4 440 18 those those DT cord-354029-mp5r82g4 440 19 formed form VBN cord-354029-mp5r82g4 440 20 by by IN cord-354029-mp5r82g4 440 21 wt wt NN cord-354029-mp5r82g4 440 22 - - HYPH cord-354029-mp5r82g4 440 23 HA HA NNP cord-354029-mp5r82g4 440 24 ( ( -LRB- cord-354029-mp5r82g4 440 25 Melikyan Melikyan NNP cord-354029-mp5r82g4 440 26 et et NNP cord-354029-mp5r82g4 440 27 al al NNP cord-354029-mp5r82g4 440 28 . . NNP cord-354029-mp5r82g4 440 29 1997b 1997b CD cord-354029-mp5r82g4 440 30 ) ) -RRB- cord-354029-mp5r82g4 440 31 . . . cord-354029-mp5r82g4 441 1 Similar similar JJ cord-354029-mp5r82g4 441 2 mutations mutation NNS cord-354029-mp5r82g4 441 3 in in IN cord-354029-mp5r82g4 441 4 HA HA NNP cord-354029-mp5r82g4 441 5 from from IN cord-354029-mp5r82g4 441 6 the the DT cord-354029-mp5r82g4 441 7 A A NNP cord-354029-mp5r82g4 441 8 / / SYM cord-354029-mp5r82g4 441 9 USSR/77 ussr/77 NN cord-354029-mp5r82g4 441 10 ( ( -LRB- cord-354029-mp5r82g4 441 11 H1N1 H1N1 NNP cord-354029-mp5r82g4 441 12 ) ) -RRB- cord-354029-mp5r82g4 441 13 and and CC cord-354029-mp5r82g4 441 14 A A NNP cord-354029-mp5r82g4 441 15 / / SYM cord-354029-mp5r82g4 441 16 FPV FPV NNP cord-354029-mp5r82g4 441 17 / / SYM cord-354029-mp5r82g4 441 18 Rostock/34 rostock/34 CD cord-354029-mp5r82g4 441 19 ( ( -LRB- cord-354029-mp5r82g4 441 20 H7N1 H7N1 NNP cord-354029-mp5r82g4 441 21 ) ) -RRB- cord-354029-mp5r82g4 442 1 influenza influenza NN cord-354029-mp5r82g4 442 2 subtypes subtype NNS cord-354029-mp5r82g4 442 3 were be VBD cord-354029-mp5r82g4 442 4 shown show VBN cord-354029-mp5r82g4 442 5 , , , cord-354029-mp5r82g4 442 6 respectively respectively RB cord-354029-mp5r82g4 442 7 , , , cord-354029-mp5r82g4 442 8 to to TO cord-354029-mp5r82g4 442 9 inhibit inhibit VB cord-354029-mp5r82g4 442 10 syncytia syncytia NN cord-354029-mp5r82g4 442 11 formation formation NN cord-354029-mp5r82g4 442 12 ( ( -LRB- cord-354029-mp5r82g4 442 13 Fischer Fischer NNP cord-354029-mp5r82g4 442 14 et et NNP cord-354029-mp5r82g4 442 15 al al NNP cord-354029-mp5r82g4 442 16 . . NNP cord-354029-mp5r82g4 442 17 1998 1998 CD cord-354029-mp5r82g4 442 18 ) ) -RRB- cord-354029-mp5r82g4 442 19 and and CC cord-354029-mp5r82g4 442 20 the the DT cord-354029-mp5r82g4 442 21 transition transition NN cord-354029-mp5r82g4 442 22 from from IN cord-354029-mp5r82g4 442 23 hemifusion hemifusion NN cord-354029-mp5r82g4 442 24 to to IN cord-354029-mp5r82g4 442 25 full full JJ cord-354029-mp5r82g4 442 26 fusion fusion NN cord-354029-mp5r82g4 442 27 . . . cord-354029-mp5r82g4 443 1 Palmitoylation Palmitoylation NNP cord-354029-mp5r82g4 443 2 of of IN cord-354029-mp5r82g4 443 3 HIV HIV NNP cord-354029-mp5r82g4 443 4 Env Env NNP cord-354029-mp5r82g4 443 5 was be VBD cord-354029-mp5r82g4 443 6 also also RB cord-354029-mp5r82g4 443 7 shown show VBN cord-354029-mp5r82g4 443 8 to to TO cord-354029-mp5r82g4 443 9 be be VB cord-354029-mp5r82g4 443 10 important important JJ cord-354029-mp5r82g4 443 11 for for IN cord-354029-mp5r82g4 443 12 Env env NN cord-354029-mp5r82g4 443 13 incorporation incorporation NN cord-354029-mp5r82g4 443 14 into into IN cord-354029-mp5r82g4 443 15 virions virion NNS cord-354029-mp5r82g4 443 16 and and CC cord-354029-mp5r82g4 443 17 for for IN cord-354029-mp5r82g4 443 18 infectivity infectivity NN cord-354029-mp5r82g4 444 1 ( ( -LRB- cord-354029-mp5r82g4 444 2 Rousso Rousso NNP cord-354029-mp5r82g4 444 3 et et FW cord-354029-mp5r82g4 444 4 al al NNP cord-354029-mp5r82g4 444 5 . . . cord-354029-mp5r82g4 444 6 2000 2000 CD cord-354029-mp5r82g4 444 7 ) ) -RRB- cord-354029-mp5r82g4 444 8 . . . cord-354029-mp5r82g4 445 1 Thus thus RB cord-354029-mp5r82g4 445 2 acylation acylation NN cord-354029-mp5r82g4 445 3 of of IN cord-354029-mp5r82g4 445 4 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 445 5 tails tail NNS cord-354029-mp5r82g4 445 6 appears appear VBZ cord-354029-mp5r82g4 445 7 to to TO cord-354029-mp5r82g4 445 8 have have VB cord-354029-mp5r82g4 445 9 multiple multiple JJ cord-354029-mp5r82g4 445 10 effects effect NNS cord-354029-mp5r82g4 445 11 on on IN cord-354029-mp5r82g4 445 12 viral viral JJ cord-354029-mp5r82g4 445 13 fusion fusion NN cord-354029-mp5r82g4 445 14 reactions reaction NNS cord-354029-mp5r82g4 445 15 , , , cord-354029-mp5r82g4 445 16 the the DT cord-354029-mp5r82g4 445 17 details detail NNS cord-354029-mp5r82g4 445 18 of of IN cord-354029-mp5r82g4 445 19 which which WDT cord-354029-mp5r82g4 445 20 are be VBP cord-354029-mp5r82g4 445 21 not not RB cord-354029-mp5r82g4 445 22 completely completely RB cord-354029-mp5r82g4 445 23 understood understand VBN cord-354029-mp5r82g4 445 24 . . . cord-354029-mp5r82g4 446 1 Lipid lipid NN cord-354029-mp5r82g4 446 2 rafts raft NNS cord-354029-mp5r82g4 446 3 are be VBP cord-354029-mp5r82g4 446 4 plasma plasma NN cord-354029-mp5r82g4 446 5 membrane membrane NN cord-354029-mp5r82g4 446 6 microdomains microdomain NNS cord-354029-mp5r82g4 446 7 that that WDT cord-354029-mp5r82g4 446 8 are be VBP cord-354029-mp5r82g4 446 9 enriched enrich VBN cord-354029-mp5r82g4 446 10 in in IN cord-354029-mp5r82g4 446 11 cholesterol cholesterol NN cord-354029-mp5r82g4 446 12 and and CC cord-354029-mp5r82g4 446 13 glycosphingolipids glycosphingolipid NNS cord-354029-mp5r82g4 446 14 with with IN cord-354029-mp5r82g4 446 15 saturated saturated JJ cord-354029-mp5r82g4 446 16 acyl acyl NN cord-354029-mp5r82g4 446 17 chains chain NNS cord-354029-mp5r82g4 446 18 . . . cord-354029-mp5r82g4 447 1 They -PRON- PRP cord-354029-mp5r82g4 447 2 are be VBP cord-354029-mp5r82g4 447 3 organizational organizational JJ cord-354029-mp5r82g4 447 4 platforms platform NNS cord-354029-mp5r82g4 447 5 for for IN cord-354029-mp5r82g4 447 6 a a DT cord-354029-mp5r82g4 447 7 variety variety NN cord-354029-mp5r82g4 447 8 of of IN cord-354029-mp5r82g4 447 9 cellular cellular JJ cord-354029-mp5r82g4 447 10 functions function NNS cord-354029-mp5r82g4 447 11 including include VBG cord-354029-mp5r82g4 447 12 sorting sorting NN cord-354029-mp5r82g4 447 13 of of IN cord-354029-mp5r82g4 447 14 membrane membrane NN cord-354029-mp5r82g4 447 15 proteins protein NNS cord-354029-mp5r82g4 447 16 and and CC cord-354029-mp5r82g4 447 17 signaling signal VBG cord-354029-mp5r82g4 447 18 ( ( -LRB- cord-354029-mp5r82g4 447 19 Brown Brown NNP cord-354029-mp5r82g4 447 20 and and CC cord-354029-mp5r82g4 447 21 London London NNP cord-354029-mp5r82g4 447 22 2000 2000 CD cord-354029-mp5r82g4 447 23 ) ) -RRB- cord-354029-mp5r82g4 447 24 . . . cord-354029-mp5r82g4 448 1 Although although IN cord-354029-mp5r82g4 448 2 there there EX cord-354029-mp5r82g4 448 3 is be VBZ cord-354029-mp5r82g4 448 4 growing grow VBG cord-354029-mp5r82g4 448 5 evidence evidence NN cord-354029-mp5r82g4 448 6 that that IN cord-354029-mp5r82g4 448 7 certain certain JJ cord-354029-mp5r82g4 448 8 viruses virus NNS cord-354029-mp5r82g4 448 9 employ employ VBP cord-354029-mp5r82g4 448 10 rafts raft NNS cord-354029-mp5r82g4 448 11 , , , cord-354029-mp5r82g4 448 12 or or CC cord-354029-mp5r82g4 448 13 raftlike raftlike JJ cord-354029-mp5r82g4 448 14 membrane membrane NN cord-354029-mp5r82g4 448 15 microdomains microdomain NNS cord-354029-mp5r82g4 448 16 , , , cord-354029-mp5r82g4 448 17 during during IN cord-354029-mp5r82g4 448 18 virus virus NN cord-354029-mp5r82g4 448 19 assembly assembly NN cord-354029-mp5r82g4 448 20 ( ( -LRB- cord-354029-mp5r82g4 448 21 Suomalainen Suomalainen NNP cord-354029-mp5r82g4 448 22 2002 2002 CD cord-354029-mp5r82g4 448 23 ) ) -RRB- cord-354029-mp5r82g4 448 24 , , , cord-354029-mp5r82g4 448 25 the the DT cord-354029-mp5r82g4 448 26 question question NN cord-354029-mp5r82g4 448 27 of of IN cord-354029-mp5r82g4 448 28 whether whether IN cord-354029-mp5r82g4 448 29 these these DT cord-354029-mp5r82g4 448 30 structures structure NNS cord-354029-mp5r82g4 448 31 are be VBP cord-354029-mp5r82g4 448 32 required require VBN cord-354029-mp5r82g4 448 33 at at IN cord-354029-mp5r82g4 448 34 the the DT cord-354029-mp5r82g4 448 35 site site NN cord-354029-mp5r82g4 448 36 of of IN cord-354029-mp5r82g4 448 37 fusion fusion NN cord-354029-mp5r82g4 448 38 in in IN cord-354029-mp5r82g4 448 39 the the DT cord-354029-mp5r82g4 448 40 target target NN cord-354029-mp5r82g4 448 41 cell cell NN cord-354029-mp5r82g4 448 42 is be VBZ cord-354029-mp5r82g4 448 43 less less RBR cord-354029-mp5r82g4 448 44 clear clear JJ cord-354029-mp5r82g4 448 45 . . . cord-354029-mp5r82g4 449 1 Here here RB cord-354029-mp5r82g4 449 2 , , , cord-354029-mp5r82g4 449 3 we -PRON- PRP cord-354029-mp5r82g4 449 4 consider consider VBP cord-354029-mp5r82g4 449 5 the the DT cord-354029-mp5r82g4 449 6 role role NN cord-354029-mp5r82g4 449 7 of of IN cord-354029-mp5r82g4 449 8 rafts raft NNS cord-354029-mp5r82g4 449 9 in in IN cord-354029-mp5r82g4 449 10 the the DT cord-354029-mp5r82g4 449 11 fusion fusion NN cord-354029-mp5r82g4 449 12 of of IN cord-354029-mp5r82g4 449 13 two two CD cord-354029-mp5r82g4 449 14 enveloped envelop VBN cord-354029-mp5r82g4 449 15 viruses virus NNS cord-354029-mp5r82g4 449 16 , , , cord-354029-mp5r82g4 449 17 SFV SFV NNP cord-354029-mp5r82g4 449 18 and and CC cord-354029-mp5r82g4 449 19 HIV HIV NNP cord-354029-mp5r82g4 449 20 . . . cord-354029-mp5r82g4 450 1 It -PRON- PRP cord-354029-mp5r82g4 450 2 is be VBZ cord-354029-mp5r82g4 450 3 important important JJ cord-354029-mp5r82g4 450 4 to to TO cord-354029-mp5r82g4 450 5 consider consider VB cord-354029-mp5r82g4 450 6 whether whether IN cord-354029-mp5r82g4 450 7 cholesterol cholesterol NN cord-354029-mp5r82g4 450 8 and/or and/or CC cord-354029-mp5r82g4 450 9 sphingolipids sphingolipid NNS cord-354029-mp5r82g4 450 10 are be VBP cord-354029-mp5r82g4 450 11 required require VBN cord-354029-mp5r82g4 450 12 for for IN cord-354029-mp5r82g4 450 13 fusion fusion NN cord-354029-mp5r82g4 450 14 because because IN cord-354029-mp5r82g4 450 15 they -PRON- PRP cord-354029-mp5r82g4 450 16 are be VBP cord-354029-mp5r82g4 450 17 found find VBN cord-354029-mp5r82g4 450 18 in in IN cord-354029-mp5r82g4 450 19 lipid lipid NN cord-354029-mp5r82g4 450 20 rafts raft NNS cord-354029-mp5r82g4 450 21 , , , cord-354029-mp5r82g4 450 22 or or CC cord-354029-mp5r82g4 450 23 if if IN cord-354029-mp5r82g4 450 24 they -PRON- PRP cord-354029-mp5r82g4 450 25 serve serve VBP cord-354029-mp5r82g4 450 26 some some DT cord-354029-mp5r82g4 450 27 other other JJ cord-354029-mp5r82g4 450 28 purpose purpose NN cord-354029-mp5r82g4 450 29 . . . cord-354029-mp5r82g4 451 1 For for IN cord-354029-mp5r82g4 451 2 example example NN cord-354029-mp5r82g4 451 3 , , , cord-354029-mp5r82g4 451 4 cholesterol cholesterol NN cord-354029-mp5r82g4 451 5 may may MD cord-354029-mp5r82g4 451 6 interact interact VB cord-354029-mp5r82g4 451 7 directly directly RB cord-354029-mp5r82g4 451 8 with with IN cord-354029-mp5r82g4 451 9 the the DT cord-354029-mp5r82g4 451 10 fusion fusion NN cord-354029-mp5r82g4 451 11 protein protein NN cord-354029-mp5r82g4 451 12 , , , cord-354029-mp5r82g4 451 13 thereby thereby RB cord-354029-mp5r82g4 451 14 facilitating facilitate VBG cord-354029-mp5r82g4 451 15 its -PRON- PRP$ cord-354029-mp5r82g4 451 16 insertion insertion NN cord-354029-mp5r82g4 451 17 into into IN cord-354029-mp5r82g4 451 18 the the DT cord-354029-mp5r82g4 451 19 target target NN cord-354029-mp5r82g4 451 20 membrane membrane NN cord-354029-mp5r82g4 451 21 . . . cord-354029-mp5r82g4 452 1 Alternatively alternatively RB cord-354029-mp5r82g4 452 2 , , , cord-354029-mp5r82g4 452 3 a a DT cord-354029-mp5r82g4 452 4 need need NN cord-354029-mp5r82g4 452 5 for for IN cord-354029-mp5r82g4 452 6 cholesterol cholesterol NN cord-354029-mp5r82g4 452 7 and and CC cord-354029-mp5r82g4 452 8 sphingolipids sphingolipid NNS cord-354029-mp5r82g4 452 9 could could MD cord-354029-mp5r82g4 452 10 reflect reflect VB cord-354029-mp5r82g4 452 11 an an DT cord-354029-mp5r82g4 452 12 ability ability NN cord-354029-mp5r82g4 452 13 of of IN cord-354029-mp5r82g4 452 14 raft raft NN cord-354029-mp5r82g4 452 15 structures structure NNS cord-354029-mp5r82g4 452 16 to to TO cord-354029-mp5r82g4 452 17 concentrate concentrate VB cord-354029-mp5r82g4 452 18 viral viral JJ cord-354029-mp5r82g4 452 19 receptors receptor NNS cord-354029-mp5r82g4 452 20 . . . cord-354029-mp5r82g4 453 1 A a DT cord-354029-mp5r82g4 453 2 third third JJ cord-354029-mp5r82g4 453 3 possibility possibility NN cord-354029-mp5r82g4 453 4 is be VBZ cord-354029-mp5r82g4 453 5 that that IN cord-354029-mp5r82g4 453 6 the the DT cord-354029-mp5r82g4 453 7 cholesterol cholesterol NN cord-354029-mp5r82g4 453 8 imparts impart VBZ cord-354029-mp5r82g4 453 9 the the DT cord-354029-mp5r82g4 453 10 membrane membrane NN cord-354029-mp5r82g4 453 11 fluidity fluidity NN cord-354029-mp5r82g4 453 12 ( ( -LRB- cord-354029-mp5r82g4 453 13 or or CC cord-354029-mp5r82g4 453 14 other other JJ cord-354029-mp5r82g4 453 15 biophysical biophysical JJ cord-354029-mp5r82g4 453 16 properties property NNS cord-354029-mp5r82g4 453 17 ) ) -RRB- cord-354029-mp5r82g4 453 18 needed need VBD cord-354029-mp5r82g4 453 19 to to TO cord-354029-mp5r82g4 453 20 lower lower VB cord-354029-mp5r82g4 453 21 the the DT cord-354029-mp5r82g4 453 22 energy energy NN cord-354029-mp5r82g4 453 23 barrier barrier NN cord-354029-mp5r82g4 453 24 for for IN cord-354029-mp5r82g4 453 25 fusion fusion NN cord-354029-mp5r82g4 453 26 . . . cord-354029-mp5r82g4 454 1 SFV SFV NNP cord-354029-mp5r82g4 454 2 requires require VBZ cord-354029-mp5r82g4 454 3 cholesterol cholesterol NN cord-354029-mp5r82g4 454 4 and and CC cord-354029-mp5r82g4 454 5 sphingolipids sphingolipid NNS cord-354029-mp5r82g4 454 6 in in IN cord-354029-mp5r82g4 454 7 the the DT cord-354029-mp5r82g4 454 8 target target NN cord-354029-mp5r82g4 454 9 membrane membrane NN cord-354029-mp5r82g4 454 10 for for IN cord-354029-mp5r82g4 454 11 fusion fusion NN cord-354029-mp5r82g4 454 12 . . . cord-354029-mp5r82g4 455 1 These these DT cord-354029-mp5r82g4 455 2 moieties moiety NNS cord-354029-mp5r82g4 455 3 enable enable VBP cord-354029-mp5r82g4 455 4 the the DT cord-354029-mp5r82g4 455 5 SFV sfv NN cord-354029-mp5r82g4 455 6 spike spike NN cord-354029-mp5r82g4 455 7 protein protein NN cord-354029-mp5r82g4 455 8 to to TO cord-354029-mp5r82g4 455 9 undergo undergo VB cord-354029-mp5r82g4 455 10 conformational conformational JJ cord-354029-mp5r82g4 455 11 changes change NNS cord-354029-mp5r82g4 455 12 and and CC cord-354029-mp5r82g4 455 13 bind bind VB cord-354029-mp5r82g4 455 14 to to IN cord-354029-mp5r82g4 455 15 the the DT cord-354029-mp5r82g4 455 16 target target NN cord-354029-mp5r82g4 455 17 membrane membrane NN cord-354029-mp5r82g4 455 18 ( ( -LRB- cord-354029-mp5r82g4 455 19 Ahn Ahn NNP cord-354029-mp5r82g4 455 20 et et NNP cord-354029-mp5r82g4 455 21 al al NNP cord-354029-mp5r82g4 455 22 . . . cord-354029-mp5r82g4 455 23 2002 2002 CD cord-354029-mp5r82g4 455 24 ; ; : cord-354029-mp5r82g4 455 25 Kielian Kielian NNP cord-354029-mp5r82g4 455 26 et et NNP cord-354029-mp5r82g4 455 27 al al NNP cord-354029-mp5r82g4 455 28 . . . cord-354029-mp5r82g4 455 29 2000 2000 CD cord-354029-mp5r82g4 455 30 ) ) -RRB- cord-354029-mp5r82g4 455 31 . . . cord-354029-mp5r82g4 456 1 In in IN cord-354029-mp5r82g4 456 2 a a DT cord-354029-mp5r82g4 456 3 recent recent JJ cord-354029-mp5r82g4 456 4 study study NN cord-354029-mp5r82g4 456 5 , , , cord-354029-mp5r82g4 456 6 it -PRON- PRP cord-354029-mp5r82g4 456 7 was be VBD cord-354029-mp5r82g4 456 8 shown show VBN cord-354029-mp5r82g4 456 9 that that IN cord-354029-mp5r82g4 456 10 after after IN cord-354029-mp5r82g4 456 11 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 456 12 association association NN cord-354029-mp5r82g4 456 13 with with IN cord-354029-mp5r82g4 456 14 target target NN cord-354029-mp5r82g4 456 15 bilayers bilayer NNS cord-354029-mp5r82g4 456 16 , , , cord-354029-mp5r82g4 456 17 the the DT cord-354029-mp5r82g4 456 18 SFV SFV NNP cord-354029-mp5r82g4 456 19 glycoprotein glycoprotein NN cord-354029-mp5r82g4 456 20 ectodomain ectodomain NNP cord-354029-mp5r82g4 456 21 associates associate NNS cord-354029-mp5r82g4 456 22 with with IN cord-354029-mp5r82g4 456 23 membrane membrane NN cord-354029-mp5r82g4 456 24 structures structure NNS cord-354029-mp5r82g4 456 25 with with IN cord-354029-mp5r82g4 456 26 properties property NNS cord-354029-mp5r82g4 456 27 similar similar JJ cord-354029-mp5r82g4 456 28 to to IN cord-354029-mp5r82g4 456 29 rafts raft NNS cord-354029-mp5r82g4 456 30 . . . cord-354029-mp5r82g4 457 1 However however RB cord-354029-mp5r82g4 457 2 , , , cord-354029-mp5r82g4 457 3 careful careful JJ cord-354029-mp5r82g4 457 4 studies study NNS cord-354029-mp5r82g4 457 5 using use VBG cord-354029-mp5r82g4 457 6 liposomes liposome NNS cord-354029-mp5r82g4 457 7 prepared prepare VBN cord-354029-mp5r82g4 457 8 with with IN cord-354029-mp5r82g4 457 9 specific specific JJ cord-354029-mp5r82g4 457 10 cholesterol cholesterol NN cord-354029-mp5r82g4 457 11 and and CC cord-354029-mp5r82g4 457 12 sphingolipid sphingolipid NN cord-354029-mp5r82g4 457 13 analogs analog NNS cord-354029-mp5r82g4 457 14 demonstrated demonstrate VBD cord-354029-mp5r82g4 457 15 that that IN cord-354029-mp5r82g4 457 16 the the DT cord-354029-mp5r82g4 457 17 cholesterol cholesterol NN cord-354029-mp5r82g4 457 18 and and CC cord-354029-mp5r82g4 457 19 sphingolipid sphingolipid NN cord-354029-mp5r82g4 457 20 requirements requirement NNS cord-354029-mp5r82g4 457 21 in in IN cord-354029-mp5r82g4 457 22 the the DT cord-354029-mp5r82g4 457 23 target target NN cord-354029-mp5r82g4 457 24 membrane membrane NN cord-354029-mp5r82g4 457 25 did do VBD cord-354029-mp5r82g4 457 26 not not RB cord-354029-mp5r82g4 457 27 correlate correlate VB cord-354029-mp5r82g4 457 28 with with IN cord-354029-mp5r82g4 457 29 their -PRON- PRP$ cord-354029-mp5r82g4 457 30 ability ability NN cord-354029-mp5r82g4 457 31 to to TO cord-354029-mp5r82g4 457 32 form form VB cord-354029-mp5r82g4 457 33 lipid lipid NN cord-354029-mp5r82g4 457 34 rafts raft NNS cord-354029-mp5r82g4 457 35 ( ( -LRB- cord-354029-mp5r82g4 457 36 Ahn Ahn NNP cord-354029-mp5r82g4 457 37 et et NNP cord-354029-mp5r82g4 457 38 al al NNP cord-354029-mp5r82g4 457 39 . . . cord-354029-mp5r82g4 457 40 2002 2002 CD cord-354029-mp5r82g4 457 41 ) ) -RRB- cord-354029-mp5r82g4 457 42 . . . cord-354029-mp5r82g4 458 1 A a DT cord-354029-mp5r82g4 458 2 related related JJ cord-354029-mp5r82g4 458 3 conclusion conclusion NN cord-354029-mp5r82g4 458 4 was be VBD cord-354029-mp5r82g4 458 5 drawn draw VBN cord-354029-mp5r82g4 458 6 based base VBN cord-354029-mp5r82g4 458 7 on on IN cord-354029-mp5r82g4 458 8 the the DT cord-354029-mp5r82g4 458 9 fusion fusion NN cord-354029-mp5r82g4 458 10 activities activity NNS cord-354029-mp5r82g4 458 11 of of IN cord-354029-mp5r82g4 458 12 both both CC cord-354029-mp5r82g4 458 13 SFV SFV NNP cord-354029-mp5r82g4 458 14 and and CC cord-354029-mp5r82g4 458 15 Sindbis Sindbis NNP cord-354029-mp5r82g4 458 16 virus virus NN cord-354029-mp5r82g4 458 17 with with IN cord-354029-mp5r82g4 458 18 liposomes liposome NNS cord-354029-mp5r82g4 459 1 ( ( -LRB- cord-354029-mp5r82g4 459 2 Waarts Waarts NNP cord-354029-mp5r82g4 459 3 et et NNP cord-354029-mp5r82g4 459 4 al al NNP cord-354029-mp5r82g4 459 5 . . . cord-354029-mp5r82g4 459 6 2002 2002 CD cord-354029-mp5r82g4 459 7 ) ) -RRB- cord-354029-mp5r82g4 459 8 . . . cord-354029-mp5r82g4 460 1 For for IN cord-354029-mp5r82g4 460 2 both both DT cord-354029-mp5r82g4 460 3 viruses virus NNS cord-354029-mp5r82g4 460 4 , , , cord-354029-mp5r82g4 460 5 the the DT cord-354029-mp5r82g4 460 6 requirement requirement NN cord-354029-mp5r82g4 460 7 for for IN cord-354029-mp5r82g4 460 8 cholesterol cholesterol NN cord-354029-mp5r82g4 460 9 and and CC cord-354029-mp5r82g4 460 10 sphingolipids sphingolipid NNS cord-354029-mp5r82g4 460 11 in in IN cord-354029-mp5r82g4 460 12 the the DT cord-354029-mp5r82g4 460 13 target target NN cord-354029-mp5r82g4 460 14 membrane membrane NN cord-354029-mp5r82g4 460 15 appears appear VBZ cord-354029-mp5r82g4 460 16 to to TO cord-354029-mp5r82g4 460 17 be be VB cord-354029-mp5r82g4 460 18 for for IN cord-354029-mp5r82g4 460 19 insertion insertion NN cord-354029-mp5r82g4 460 20 of of IN cord-354029-mp5r82g4 460 21 the the DT cord-354029-mp5r82g4 460 22 fusion fusion NN cord-354029-mp5r82g4 460 23 peptide peptide NN cord-354029-mp5r82g4 460 24 ( ( -LRB- cord-354029-mp5r82g4 460 25 Vashishtha Vashishtha NNP cord-354029-mp5r82g4 460 26 et et FW cord-354029-mp5r82g4 460 27 al al NNP cord-354029-mp5r82g4 460 28 . . NNP cord-354029-mp5r82g4 460 29 1998 1998 CD cord-354029-mp5r82g4 460 30 ) ) -RRB- cord-354029-mp5r82g4 460 31 . . . cord-354029-mp5r82g4 461 1 In in IN cord-354029-mp5r82g4 461 2 the the DT cord-354029-mp5r82g4 461 3 case case NN cord-354029-mp5r82g4 461 4 of of IN cord-354029-mp5r82g4 461 5 HIV HIV NNP cord-354029-mp5r82g4 461 6 , , , cord-354029-mp5r82g4 461 7 several several JJ cord-354029-mp5r82g4 461 8 studies study NNS cord-354029-mp5r82g4 461 9 have have VBP cord-354029-mp5r82g4 461 10 suggested suggest VBN cord-354029-mp5r82g4 461 11 a a DT cord-354029-mp5r82g4 461 12 need need NN cord-354029-mp5r82g4 461 13 for for IN cord-354029-mp5r82g4 461 14 raftlike raftlike JJ cord-354029-mp5r82g4 461 15 membrane membrane NN cord-354029-mp5r82g4 461 16 microdomains microdomain NNS cord-354029-mp5r82g4 461 17 for for IN cord-354029-mp5r82g4 461 18 virus virus NN cord-354029-mp5r82g4 461 19 entry entry NN cord-354029-mp5r82g4 462 1 ( ( -LRB- cord-354029-mp5r82g4 462 2 Kozak Kozak NNP cord-354029-mp5r82g4 462 3 et et NNP cord-354029-mp5r82g4 462 4 al al NNP cord-354029-mp5r82g4 462 5 . . . cord-354029-mp5r82g4 463 1 2002 2002 CD cord-354029-mp5r82g4 463 2 ; ; : cord-354029-mp5r82g4 463 3 Popik Popik NNP cord-354029-mp5r82g4 463 4 et et NNP cord-354029-mp5r82g4 463 5 al al NNP cord-354029-mp5r82g4 463 6 . . . cord-354029-mp5r82g4 463 7 2002 2002 CD cord-354029-mp5r82g4 463 8 ) ) -RRB- cord-354029-mp5r82g4 463 9 . . . cord-354029-mp5r82g4 464 1 Depleting deplete VBG cord-354029-mp5r82g4 464 2 plasma plasma NN cord-354029-mp5r82g4 464 3 membrane membrane NN cord-354029-mp5r82g4 464 4 cholesterol cholesterol NN cord-354029-mp5r82g4 464 5 from from IN cord-354029-mp5r82g4 464 6 target target NN cord-354029-mp5r82g4 464 7 cells cell NNS cord-354029-mp5r82g4 464 8 resulted result VBD cord-354029-mp5r82g4 464 9 in in IN cord-354029-mp5r82g4 464 10 reduced reduce VBN cord-354029-mp5r82g4 464 11 levels level NNS cord-354029-mp5r82g4 464 12 of of IN cord-354029-mp5r82g4 464 13 virus virus NN cord-354029-mp5r82g4 464 14 infectivity infectivity NN cord-354029-mp5r82g4 464 15 or or CC cord-354029-mp5r82g4 464 16 cell cell NN cord-354029-mp5r82g4 464 17 - - HYPH cord-354029-mp5r82g4 464 18 cell cell NN cord-354029-mp5r82g4 464 19 fusion fusion NN cord-354029-mp5r82g4 464 20 . . . cord-354029-mp5r82g4 465 1 Other other JJ cord-354029-mp5r82g4 465 2 studies study NNS cord-354029-mp5r82g4 465 3 have have VBP cord-354029-mp5r82g4 465 4 concluded conclude VBN cord-354029-mp5r82g4 465 5 that that IN cord-354029-mp5r82g4 465 6 rafts raft NNS cord-354029-mp5r82g4 465 7 are be VBP cord-354029-mp5r82g4 465 8 not not RB cord-354029-mp5r82g4 465 9 necessary necessary JJ cord-354029-mp5r82g4 465 10 for for IN cord-354029-mp5r82g4 465 11 HIV HIV NNP cord-354029-mp5r82g4 465 12 entry entry NN cord-354029-mp5r82g4 466 1 ( ( -LRB- cord-354029-mp5r82g4 466 2 Percherancier Percherancier NNP cord-354029-mp5r82g4 466 3 et et NNP cord-354029-mp5r82g4 466 4 al al NNP cord-354029-mp5r82g4 466 5 . . . cord-354029-mp5r82g4 467 1 2003 2003 CD cord-354029-mp5r82g4 467 2 ; ; : cord-354029-mp5r82g4 467 3 Viard Viard NNP cord-354029-mp5r82g4 467 4 et et NNP cord-354029-mp5r82g4 467 5 al al NNP cord-354029-mp5r82g4 467 6 . . . cord-354029-mp5r82g4 467 7 2002 2002 CD cord-354029-mp5r82g4 467 8 ) ) -RRB- cord-354029-mp5r82g4 467 9 . . . cord-354029-mp5r82g4 468 1 In in IN cord-354029-mp5r82g4 468 2 one one CD cord-354029-mp5r82g4 468 3 study study NN cord-354029-mp5r82g4 468 4 , , , cord-354029-mp5r82g4 468 5 depleting deplete VBG cord-354029-mp5r82g4 468 6 cholesterol cholesterol NN cord-354029-mp5r82g4 468 7 from from IN cord-354029-mp5r82g4 468 8 cells cell NNS cord-354029-mp5r82g4 468 9 that that WDT cord-354029-mp5r82g4 468 10 express express VBP cord-354029-mp5r82g4 468 11 low low JJ cord-354029-mp5r82g4 468 12 levels level NNS cord-354029-mp5r82g4 468 13 of of IN cord-354029-mp5r82g4 468 14 virus virus NN cord-354029-mp5r82g4 468 15 receptors receptor NNS cord-354029-mp5r82g4 468 16 inhibited inhibit VBD cord-354029-mp5r82g4 468 17 HIV HIV NNP cord-354029-mp5r82g4 468 18 Env Env NNP cord-354029-mp5r82g4 468 19 - - HYPH cord-354029-mp5r82g4 468 20 mediated mediate VBN cord-354029-mp5r82g4 468 21 cell cell NN cord-354029-mp5r82g4 468 22 - - HYPH cord-354029-mp5r82g4 468 23 cell cell NN cord-354029-mp5r82g4 468 24 fusion fusion NN cord-354029-mp5r82g4 468 25 , , , cord-354029-mp5r82g4 468 26 but but CC cord-354029-mp5r82g4 468 27 depleting deplete VBG cord-354029-mp5r82g4 468 28 cholesterol cholesterol NN cord-354029-mp5r82g4 468 29 from from IN cord-354029-mp5r82g4 468 30 cells cell NNS cord-354029-mp5r82g4 468 31 that that WDT cord-354029-mp5r82g4 468 32 express express VBP cord-354029-mp5r82g4 468 33 high high JJ cord-354029-mp5r82g4 468 34 levels level NNS cord-354029-mp5r82g4 468 35 of of IN cord-354029-mp5r82g4 468 36 virus virus NN cord-354029-mp5r82g4 468 37 receptors receptor NNS cord-354029-mp5r82g4 468 38 did do VBD cord-354029-mp5r82g4 468 39 not not RB cord-354029-mp5r82g4 468 40 ( ( -LRB- cord-354029-mp5r82g4 468 41 Viard Viard NNP cord-354029-mp5r82g4 468 42 et et NNP cord-354029-mp5r82g4 468 43 al al NNP cord-354029-mp5r82g4 468 44 . . . cord-354029-mp5r82g4 468 45 2002 2002 CD cord-354029-mp5r82g4 468 46 ) ) -RRB- cord-354029-mp5r82g4 468 47 . . . cord-354029-mp5r82g4 469 1 Therefore therefore RB cord-354029-mp5r82g4 469 2 , , , cord-354029-mp5r82g4 469 3 it -PRON- PRP cord-354029-mp5r82g4 469 4 was be VBD cord-354029-mp5r82g4 469 5 concluded conclude VBN cord-354029-mp5r82g4 469 6 that that IN cord-354029-mp5r82g4 469 7 rafts raft NNS cord-354029-mp5r82g4 469 8 per per IN cord-354029-mp5r82g4 469 9 se se FW cord-354029-mp5r82g4 469 10 are be VBP cord-354029-mp5r82g4 469 11 not not RB cord-354029-mp5r82g4 469 12 needed need VBN cord-354029-mp5r82g4 469 13 for for IN cord-354029-mp5r82g4 469 14 fusion fusion NN cord-354029-mp5r82g4 469 15 . . . cord-354029-mp5r82g4 470 1 Rather rather RB cord-354029-mp5r82g4 470 2 , , , cord-354029-mp5r82g4 470 3 the the DT cord-354029-mp5r82g4 470 4 presence presence NN cord-354029-mp5r82g4 470 5 of of IN cord-354029-mp5r82g4 470 6 raftlike raftlike JJ cord-354029-mp5r82g4 470 7 structures structure NNS cord-354029-mp5r82g4 470 8 in in IN cord-354029-mp5r82g4 470 9 the the DT cord-354029-mp5r82g4 470 10 plasma plasma NN cord-354029-mp5r82g4 470 11 membrane membrane NN cord-354029-mp5r82g4 470 12 may may MD cord-354029-mp5r82g4 470 13 concentrate concentrate VB cord-354029-mp5r82g4 470 14 virus virus NN cord-354029-mp5r82g4 470 15 receptors receptor NNS cord-354029-mp5r82g4 470 16 . . . cord-354029-mp5r82g4 471 1 Previous previous JJ cord-354029-mp5r82g4 471 2 work work NN cord-354029-mp5r82g4 471 3 has have VBZ cord-354029-mp5r82g4 471 4 shown show VBN cord-354029-mp5r82g4 471 5 that that IN cord-354029-mp5r82g4 471 6 a a DT cord-354029-mp5r82g4 471 7 critical critical JJ cord-354029-mp5r82g4 471 8 density density NN cord-354029-mp5r82g4 471 9 of of IN cord-354029-mp5r82g4 471 10 HIV HIV NNP cord-354029-mp5r82g4 471 11 receptors receptor NNS cord-354029-mp5r82g4 471 12 is be VBZ cord-354029-mp5r82g4 471 13 required require VBN cord-354029-mp5r82g4 471 14 for for IN cord-354029-mp5r82g4 471 15 fusion fusion NN cord-354029-mp5r82g4 471 16 and and CC cord-354029-mp5r82g4 471 17 infection infection NN cord-354029-mp5r82g4 471 18 ( ( -LRB- cord-354029-mp5r82g4 471 19 Reeves Reeves NNP cord-354029-mp5r82g4 471 20 et et NNP cord-354029-mp5r82g4 471 21 al al NNP cord-354029-mp5r82g4 471 22 . . . cord-354029-mp5r82g4 471 23 2002 2002 CD cord-354029-mp5r82g4 471 24 ) ) -RRB- cord-354029-mp5r82g4 471 25 . . . cord-354029-mp5r82g4 472 1 Clearly clearly RB cord-354029-mp5r82g4 472 2 more more JJR cord-354029-mp5r82g4 472 3 work work NN cord-354029-mp5r82g4 472 4 is be VBZ cord-354029-mp5r82g4 472 5 needed need VBN cord-354029-mp5r82g4 472 6 to to TO cord-354029-mp5r82g4 472 7 clarify clarify VB cord-354029-mp5r82g4 472 8 the the DT cord-354029-mp5r82g4 472 9 role role NN cord-354029-mp5r82g4 472 10 of of IN cord-354029-mp5r82g4 472 11 rafts raft NNS cord-354029-mp5r82g4 472 12 in in IN cord-354029-mp5r82g4 472 13 virus virus NN cord-354029-mp5r82g4 472 14 - - HYPH cord-354029-mp5r82g4 472 15 cell cell NN cord-354029-mp5r82g4 472 16 fusion fusion NN cord-354029-mp5r82g4 472 17 and and CC cord-354029-mp5r82g4 472 18 entry entry NN cord-354029-mp5r82g4 472 19 . . . cord-354029-mp5r82g4 473 1 It -PRON- PRP cord-354029-mp5r82g4 473 2 has have VBZ cord-354029-mp5r82g4 473 3 recently recently RB cord-354029-mp5r82g4 473 4 become become VBN cord-354029-mp5r82g4 473 5 apparent apparent JJ cord-354029-mp5r82g4 473 6 , , , cord-354029-mp5r82g4 473 7 largely largely RB cord-354029-mp5r82g4 473 8 because because IN cord-354029-mp5r82g4 473 9 of of IN cord-354029-mp5r82g4 473 10 the the DT cord-354029-mp5r82g4 473 11 success success NN cord-354029-mp5r82g4 473 12 of of IN cord-354029-mp5r82g4 473 13 T-20 T-20 NNP cord-354029-mp5r82g4 473 14 in in IN cord-354029-mp5r82g4 473 15 the the DT cord-354029-mp5r82g4 473 16 inhibition inhibition NN cord-354029-mp5r82g4 473 17 of of IN cord-354029-mp5r82g4 473 18 HIV HIV NNP cord-354029-mp5r82g4 473 19 infection infection NN cord-354029-mp5r82g4 473 20 in in IN cord-354029-mp5r82g4 473 21 patients patient NNS cord-354029-mp5r82g4 473 22 ( ( -LRB- cord-354029-mp5r82g4 473 23 Jiang Jiang NNP cord-354029-mp5r82g4 473 24 et et FW cord-354029-mp5r82g4 473 25 al al NNP cord-354029-mp5r82g4 473 26 . . . cord-354029-mp5r82g4 473 27 2002 2002 CD cord-354029-mp5r82g4 473 28 ; ; : cord-354029-mp5r82g4 473 29 Kilby Kilby NNP cord-354029-mp5r82g4 473 30 et et NNP cord-354029-mp5r82g4 473 31 al al NNP cord-354029-mp5r82g4 473 32 . . . cord-354029-mp5r82g4 473 33 1998 1998 CD cord-354029-mp5r82g4 473 34 ) ) -RRB- cord-354029-mp5r82g4 473 35 , , , cord-354029-mp5r82g4 473 36 that that DT cord-354029-mp5r82g4 473 37 fusion fusion NN cord-354029-mp5r82g4 473 38 is be VBZ cord-354029-mp5r82g4 473 39 a a DT cord-354029-mp5r82g4 473 40 good good JJ cord-354029-mp5r82g4 473 41 target target NN cord-354029-mp5r82g4 473 42 for for IN cord-354029-mp5r82g4 473 43 antiviral antiviral JJ cord-354029-mp5r82g4 473 44 intervention intervention NN cord-354029-mp5r82g4 473 45 . . . cord-354029-mp5r82g4 474 1 This this DT cord-354029-mp5r82g4 474 2 was be VBD cord-354029-mp5r82g4 474 3 originally originally RB cord-354029-mp5r82g4 474 4 conceptualized conceptualize VBN cord-354029-mp5r82g4 474 5 because because IN cord-354029-mp5r82g4 474 6 fusion fusion NN cord-354029-mp5r82g4 474 7 is be VBZ cord-354029-mp5r82g4 474 8 an an DT cord-354029-mp5r82g4 474 9 essential essential JJ cord-354029-mp5r82g4 474 10 early early JJ cord-354029-mp5r82g4 474 11 step step NN cord-354029-mp5r82g4 474 12 in in IN cord-354029-mp5r82g4 474 13 the the DT cord-354029-mp5r82g4 474 14 virus virus NN cord-354029-mp5r82g4 474 15 infectious infectious JJ cord-354029-mp5r82g4 474 16 cycle cycle NN cord-354029-mp5r82g4 474 17 , , , cord-354029-mp5r82g4 474 18 it -PRON- PRP cord-354029-mp5r82g4 474 19 happens happen VBZ cord-354029-mp5r82g4 474 20 in in IN cord-354029-mp5r82g4 474 21 an an DT cord-354029-mp5r82g4 474 22 exoplasmic exoplasmic JJ cord-354029-mp5r82g4 474 23 space space NN cord-354029-mp5r82g4 474 24 , , , cord-354029-mp5r82g4 474 25 and and CC cord-354029-mp5r82g4 474 26 strategies strategy NNS cord-354029-mp5r82g4 474 27 can can MD cord-354029-mp5r82g4 474 28 be be VB cord-354029-mp5r82g4 474 29 designed design VBN cord-354029-mp5r82g4 474 30 to to TO cord-354029-mp5r82g4 474 31 inhibit inhibit VB cord-354029-mp5r82g4 474 32 fusion fusion NN cord-354029-mp5r82g4 474 33 without without IN cord-354029-mp5r82g4 474 34 interfering interfere VBG cord-354029-mp5r82g4 474 35 with with IN cord-354029-mp5r82g4 474 36 host host NN cord-354029-mp5r82g4 474 37 cell cell NN cord-354029-mp5r82g4 474 38 proteins protein NNS cord-354029-mp5r82g4 474 39 . . . cord-354029-mp5r82g4 475 1 Some some DT cord-354029-mp5r82g4 475 2 fusion fusion NN cord-354029-mp5r82g4 475 3 inhibitors inhibitor NNS cord-354029-mp5r82g4 475 4 function function VBP cord-354029-mp5r82g4 475 5 by by IN cord-354029-mp5r82g4 475 6 inhibiting inhibit VBG cord-354029-mp5r82g4 475 7 six six CD cord-354029-mp5r82g4 475 8 - - HYPH cord-354029-mp5r82g4 475 9 helix helix NN cord-354029-mp5r82g4 475 10 bundle bundle NN cord-354029-mp5r82g4 475 11 formation formation NN cord-354029-mp5r82g4 475 12 . . . cord-354029-mp5r82g4 476 1 Others other NNS cord-354029-mp5r82g4 476 2 function function VBP cord-354029-mp5r82g4 476 3 by by IN cord-354029-mp5r82g4 476 4 preventing prevent VBG cord-354029-mp5r82g4 476 5 earlier early JJR cord-354029-mp5r82g4 476 6 conformational conformational JJ cord-354029-mp5r82g4 476 7 changes change NNS cord-354029-mp5r82g4 476 8 in in IN cord-354029-mp5r82g4 476 9 viral viral JJ cord-354029-mp5r82g4 476 10 fusion fusion NN cord-354029-mp5r82g4 476 11 proteins protein NNS cord-354029-mp5r82g4 476 12 . . . cord-354029-mp5r82g4 477 1 The the DT cord-354029-mp5r82g4 477 2 peptide peptide NN cord-354029-mp5r82g4 477 3 T-20 T-20 NNP cord-354029-mp5r82g4 477 4 ( ( -LRB- cord-354029-mp5r82g4 477 5 also also RB cord-354029-mp5r82g4 477 6 known know VBN cord-354029-mp5r82g4 477 7 as as IN cord-354029-mp5r82g4 477 8 Fuzeon Fuzeon NNP cord-354029-mp5r82g4 477 9 ) ) -RRB- cord-354029-mp5r82g4 477 10 corresponds correspond VBZ cord-354029-mp5r82g4 477 11 to to IN cord-354029-mp5r82g4 477 12 the the DT cord-354029-mp5r82g4 477 13 C C NNP cord-354029-mp5r82g4 477 14 - - HYPH cord-354029-mp5r82g4 477 15 terminal terminal NN cord-354029-mp5r82g4 477 16 helix helix NN cord-354029-mp5r82g4 477 17 of of IN cord-354029-mp5r82g4 477 18 HIV HIV NNP cord-354029-mp5r82g4 477 19 Env Env NNP cord-354029-mp5r82g4 477 20 ( ( -LRB- cord-354029-mp5r82g4 477 21 Fig Fig NNP cord-354029-mp5r82g4 477 22 . . . cord-354029-mp5r82g4 477 23 3 3 CD cord-354029-mp5r82g4 477 24 , , , cord-354029-mp5r82g4 477 25 green green JJ cord-354029-mp5r82g4 477 26 ) ) -RRB- cord-354029-mp5r82g4 477 27 . . . cord-354029-mp5r82g4 478 1 T-20 T-20 NNP cord-354029-mp5r82g4 478 2 works work VBZ cord-354029-mp5r82g4 478 3 by by IN cord-354029-mp5r82g4 478 4 preventing prevent VBG cord-354029-mp5r82g4 478 5 six six CD cord-354029-mp5r82g4 478 6 - - HYPH cord-354029-mp5r82g4 478 7 helix helix NN cord-354029-mp5r82g4 478 8 bundle bundle NN cord-354029-mp5r82g4 478 9 formation formation NN cord-354029-mp5r82g4 478 10 . . . cord-354029-mp5r82g4 479 1 T-20 T-20 NNP cord-354029-mp5r82g4 479 2 is be VBZ cord-354029-mp5r82g4 479 3 a a DT cord-354029-mp5r82g4 479 4 potent potent JJ cord-354029-mp5r82g4 479 5 inhibitor inhibitor NN cord-354029-mp5r82g4 479 6 of of IN cord-354029-mp5r82g4 479 7 infections infection NNS cord-354029-mp5r82g4 479 8 in in IN cord-354029-mp5r82g4 479 9 tissue tissue NN cord-354029-mp5r82g4 479 10 culture culture NN cord-354029-mp5r82g4 479 11 . . . cord-354029-mp5r82g4 480 1 Peptides peptide NNS cord-354029-mp5r82g4 480 2 corresponding correspond VBG cord-354029-mp5r82g4 480 3 to to IN cord-354029-mp5r82g4 480 4 equivalent equivalent JJ cord-354029-mp5r82g4 480 5 regions region NNS cord-354029-mp5r82g4 480 6 of of IN cord-354029-mp5r82g4 480 7 other other JJ cord-354029-mp5r82g4 480 8 retroviruses retrovirus NNS cord-354029-mp5r82g4 480 9 as as RB cord-354029-mp5r82g4 480 10 well well RB cord-354029-mp5r82g4 480 11 as as IN cord-354029-mp5r82g4 480 12 several several JJ cord-354029-mp5r82g4 480 13 paramyxoviruses paramyxovirus NNS cord-354029-mp5r82g4 480 14 function function VBP cord-354029-mp5r82g4 480 15 similarly similarly RB cord-354029-mp5r82g4 481 1 ( ( -LRB- cord-354029-mp5r82g4 481 2 Earp Earp NNP cord-354029-mp5r82g4 481 3 et et NNP cord-354029-mp5r82g4 481 4 al al NNP cord-354029-mp5r82g4 481 5 . . . cord-354029-mp5r82g4 482 1 2003 2003 CD cord-354029-mp5r82g4 482 2 ; ; : cord-354029-mp5r82g4 482 3 Russell Russell NNP cord-354029-mp5r82g4 482 4 et et NNP cord-354029-mp5r82g4 482 5 al al NNP cord-354029-mp5r82g4 482 6 . . NNP cord-354029-mp5r82g4 482 7 2001 2001 CD cord-354029-mp5r82g4 482 8 ) ) -RRB- cord-354029-mp5r82g4 482 9 . . . cord-354029-mp5r82g4 483 1 Notably notably RB cord-354029-mp5r82g4 483 2 , , , cord-354029-mp5r82g4 483 3 all all DT cord-354029-mp5r82g4 483 4 of of IN cord-354029-mp5r82g4 483 5 the the DT cord-354029-mp5r82g4 483 6 viruses virus NNS cord-354029-mp5r82g4 483 7 that that WDT cord-354029-mp5r82g4 483 8 have have VBP cord-354029-mp5r82g4 483 9 been be VBN cord-354029-mp5r82g4 483 10 shown show VBN cord-354029-mp5r82g4 483 11 to to TO cord-354029-mp5r82g4 483 12 be be VB cord-354029-mp5r82g4 483 13 highly highly RB cord-354029-mp5r82g4 483 14 susceptible susceptible JJ cord-354029-mp5r82g4 483 15 to to IN cord-354029-mp5r82g4 483 16 " " `` cord-354029-mp5r82g4 483 17 C c NN cord-354029-mp5r82g4 483 18 - - HYPH cord-354029-mp5r82g4 483 19 helix helix NN cord-354029-mp5r82g4 483 20 " " '' cord-354029-mp5r82g4 483 21 peptide peptide NN cord-354029-mp5r82g4 483 22 inhibitors inhibitor NNS cord-354029-mp5r82g4 483 23 function function VBP cord-354029-mp5r82g4 483 24 at at IN cord-354029-mp5r82g4 483 25 neutral neutral JJ cord-354029-mp5r82g4 483 26 pH pH NNP cord-354029-mp5r82g4 483 27 , , , cord-354029-mp5r82g4 483 28 at at IN cord-354029-mp5r82g4 483 29 least least JJS cord-354029-mp5r82g4 483 30 up up IN cord-354029-mp5r82g4 483 31 to to IN cord-354029-mp5r82g4 483 32 the the DT cord-354029-mp5r82g4 483 33 lipid lipid NN cord-354029-mp5r82g4 483 34 interacting interact VBG cord-354029-mp5r82g4 483 35 stage stage NN cord-354029-mp5r82g4 483 36 of of IN cord-354029-mp5r82g4 483 37 virus virus NN cord-354029-mp5r82g4 483 38 - - HYPH cord-354029-mp5r82g4 483 39 cell cell NN cord-354029-mp5r82g4 483 40 fusion fusion NN cord-354029-mp5r82g4 484 1 ( ( -LRB- cord-354029-mp5r82g4 484 2 Earp Earp NNP cord-354029-mp5r82g4 484 3 et et NNP cord-354029-mp5r82g4 484 4 al al NNP cord-354029-mp5r82g4 484 5 . . NNP cord-354029-mp5r82g4 484 6 2003 2003 CD cord-354029-mp5r82g4 484 7 ) ) -RRB- cord-354029-mp5r82g4 484 8 . . . cord-354029-mp5r82g4 485 1 Peptides peptide NNS cord-354029-mp5r82g4 485 2 corresponding correspond VBG cord-354029-mp5r82g4 485 3 to to IN cord-354029-mp5r82g4 485 4 the the DT cord-354029-mp5r82g4 485 5 N n CD cord-354029-mp5r82g4 485 6 - - HYPH cord-354029-mp5r82g4 485 7 terminal terminal NN cord-354029-mp5r82g4 485 8 helices helix NNS cord-354029-mp5r82g4 485 9 of of IN cord-354029-mp5r82g4 485 10 HIV HIV NNP cord-354029-mp5r82g4 485 11 Env Env NNP cord-354029-mp5r82g4 485 12 and and CC cord-354029-mp5r82g4 485 13 the the DT cord-354029-mp5r82g4 485 14 SV5 SV5 NNP cord-354029-mp5r82g4 485 15 F F NNP cord-354029-mp5r82g4 485 16 protein protein NN cord-354029-mp5r82g4 485 17 also also RB cord-354029-mp5r82g4 485 18 inhibit inhibit VBP cord-354029-mp5r82g4 485 19 fusion fusion NN cord-354029-mp5r82g4 485 20 , , , cord-354029-mp5r82g4 485 21 although although IN cord-354029-mp5r82g4 485 22 with with IN cord-354029-mp5r82g4 485 23 lower low JJR cord-354029-mp5r82g4 485 24 potency potency NN cord-354029-mp5r82g4 485 25 ( ( -LRB- cord-354029-mp5r82g4 485 26 Lu Lu NNP cord-354029-mp5r82g4 485 27 et et FW cord-354029-mp5r82g4 485 28 al al NNP cord-354029-mp5r82g4 485 29 . . NNP cord-354029-mp5r82g4 485 30 1995 1995 CD cord-354029-mp5r82g4 485 31 ; ; : cord-354029-mp5r82g4 485 32 Russell Russell NNP cord-354029-mp5r82g4 485 33 et et NNP cord-354029-mp5r82g4 485 34 al al NNP cord-354029-mp5r82g4 485 35 . . NNP cord-354029-mp5r82g4 485 36 2001 2001 CD cord-354029-mp5r82g4 485 37 ) ) -RRB- cord-354029-mp5r82g4 485 38 . . . cord-354029-mp5r82g4 486 1 The the DT cord-354029-mp5r82g4 486 2 mechanism mechanism NN cord-354029-mp5r82g4 486 3 of of IN cord-354029-mp5r82g4 486 4 inhibition inhibition NN cord-354029-mp5r82g4 486 5 by by IN cord-354029-mp5r82g4 486 6 N n CD cord-354029-mp5r82g4 486 7 - - HYPH cord-354029-mp5r82g4 486 8 terminal terminal NN cord-354029-mp5r82g4 486 9 peptides peptide NNS cord-354029-mp5r82g4 486 10 is be VBZ cord-354029-mp5r82g4 486 11 still still RB cord-354029-mp5r82g4 486 12 under under IN cord-354029-mp5r82g4 486 13 consideration consideration NN cord-354029-mp5r82g4 486 14 ) ) -RRB- cord-354029-mp5r82g4 486 15 . . . cord-354029-mp5r82g4 487 1 In in IN cord-354029-mp5r82g4 487 2 the the DT cord-354029-mp5r82g4 487 3 case case NN cord-354029-mp5r82g4 487 4 of of IN cord-354029-mp5r82g4 487 5 the the DT cord-354029-mp5r82g4 487 6 SV5 SV5 NNP cord-354029-mp5r82g4 487 7 F F NNP cord-354029-mp5r82g4 487 8 , , , cord-354029-mp5r82g4 487 9 the the DT cord-354029-mp5r82g4 487 10 N N NNP cord-354029-mp5r82g4 487 11 - - HYPH cord-354029-mp5r82g4 487 12 peptide peptide NN cord-354029-mp5r82g4 487 13 appears appear VBZ cord-354029-mp5r82g4 487 14 to to TO cord-354029-mp5r82g4 487 15 target target VB cord-354029-mp5r82g4 487 16 an an DT cord-354029-mp5r82g4 487 17 earlier early JJR cord-354029-mp5r82g4 487 18 intermediate intermediate JJ cord-354029-mp5r82g4 487 19 than than IN cord-354029-mp5r82g4 487 20 the the DT cord-354029-mp5r82g4 487 21 C c NN cord-354029-mp5r82g4 487 22 - - HYPH cord-354029-mp5r82g4 487 23 peptide peptide NN cord-354029-mp5r82g4 487 24 . . . cord-354029-mp5r82g4 488 1 Other other JJ cord-354029-mp5r82g4 488 2 strategies strategy NNS cord-354029-mp5r82g4 488 3 are be VBP cord-354029-mp5r82g4 488 4 being be VBG cord-354029-mp5r82g4 488 5 considered consider VBN cord-354029-mp5r82g4 488 6 to to TO cord-354029-mp5r82g4 488 7 stabilize stabilize VB cord-354029-mp5r82g4 488 8 the the DT cord-354029-mp5r82g4 488 9 prehairpin prehairpin NN cord-354029-mp5r82g4 488 10 intermediate intermediate NN cord-354029-mp5r82g4 488 11 ( ( -LRB- cord-354029-mp5r82g4 488 12 Fig Fig NNP cord-354029-mp5r82g4 488 13 . . . cord-354029-mp5r82g4 488 14 3 3 CD cord-354029-mp5r82g4 488 15 , , , cord-354029-mp5r82g4 488 16 Step step NN cord-354029-mp5r82g4 488 17 1 1 CD cord-354029-mp5r82g4 488 18 ) ) -RRB- cord-354029-mp5r82g4 488 19 and and CC cord-354029-mp5r82g4 488 20 thereby thereby RB cord-354029-mp5r82g4 488 21 prevent prevent VB cord-354029-mp5r82g4 488 22 six six CD cord-354029-mp5r82g4 488 23 - - HYPH cord-354029-mp5r82g4 488 24 helix helix NN cord-354029-mp5r82g4 488 25 bundle bundle NN cord-354029-mp5r82g4 488 26 formation formation NN cord-354029-mp5r82g4 488 27 . . . cord-354029-mp5r82g4 489 1 One one CD cord-354029-mp5r82g4 489 2 strategy strategy NN cord-354029-mp5r82g4 489 3 is be VBZ cord-354029-mp5r82g4 489 4 the the DT cord-354029-mp5r82g4 489 5 development development NN cord-354029-mp5r82g4 489 6 of of IN cord-354029-mp5r82g4 489 7 antibodies antibody NNS cord-354029-mp5r82g4 489 8 that that WDT cord-354029-mp5r82g4 489 9 recognize recognize VBP cord-354029-mp5r82g4 489 10 the the DT cord-354029-mp5r82g4 489 11 prehairpin prehairpin NN cord-354029-mp5r82g4 489 12 intermediate intermediate NN cord-354029-mp5r82g4 489 13 ( ( -LRB- cord-354029-mp5r82g4 489 14 Golding Golding NNP cord-354029-mp5r82g4 489 15 et et NNP cord-354029-mp5r82g4 489 16 al al NNP cord-354029-mp5r82g4 489 17 . . . cord-354029-mp5r82g4 489 18 2002 2002 CD cord-354029-mp5r82g4 489 19 ) ) -RRB- cord-354029-mp5r82g4 489 20 . . . cord-354029-mp5r82g4 490 1 Another another DT cord-354029-mp5r82g4 490 2 , , , cord-354029-mp5r82g4 490 3 exemplified exemplify VBN cord-354029-mp5r82g4 490 4 in in IN cord-354029-mp5r82g4 490 5 three three CD cord-354029-mp5r82g4 490 6 studies study NNS cord-354029-mp5r82g4 490 7 , , , cord-354029-mp5r82g4 490 8 is be VBZ cord-354029-mp5r82g4 490 9 the the DT cord-354029-mp5r82g4 490 10 development development NN cord-354029-mp5r82g4 490 11 of of IN cord-354029-mp5r82g4 490 12 small small JJ cord-354029-mp5r82g4 490 13 molecules molecule NNS cord-354029-mp5r82g4 490 14 that that WDT cord-354029-mp5r82g4 490 15 prevent prevent VBP cord-354029-mp5r82g4 490 16 six six CD cord-354029-mp5r82g4 490 17 - - HYPH cord-354029-mp5r82g4 490 18 helix helix NN cord-354029-mp5r82g4 490 19 bundle bundle NN cord-354029-mp5r82g4 490 20 formation formation NN cord-354029-mp5r82g4 491 1 ( ( -LRB- cord-354029-mp5r82g4 491 2 Debnath Debnath NNP cord-354029-mp5r82g4 491 3 et et NNP cord-354029-mp5r82g4 491 4 al al NNP cord-354029-mp5r82g4 491 5 . . . cord-354029-mp5r82g4 492 1 1999 1999 CD cord-354029-mp5r82g4 492 2 ; ; : cord-354029-mp5r82g4 492 3 Eckert Eckert NNP cord-354029-mp5r82g4 492 4 et et NNP cord-354029-mp5r82g4 492 5 al al NNP cord-354029-mp5r82g4 492 6 . . . cord-354029-mp5r82g4 493 1 1999 1999 CD cord-354029-mp5r82g4 493 2 ; ; : cord-354029-mp5r82g4 493 3 Ferrer Ferrer NNP cord-354029-mp5r82g4 493 4 et et NNP cord-354029-mp5r82g4 493 5 al al NNP cord-354029-mp5r82g4 493 6 . . . cord-354029-mp5r82g4 493 7 1999 1999 CD cord-354029-mp5r82g4 493 8 ) ) -RRB- cord-354029-mp5r82g4 493 9 . . . cord-354029-mp5r82g4 494 1 All all DT cord-354029-mp5r82g4 494 2 three three CD cord-354029-mp5r82g4 494 3 studies study NNS cord-354029-mp5r82g4 494 4 targeted target VBD cord-354029-mp5r82g4 494 5 a a DT cord-354029-mp5r82g4 494 6 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 494 7 pocket pocket NN cord-354029-mp5r82g4 494 8 in in IN cord-354029-mp5r82g4 494 9 the the DT cord-354029-mp5r82g4 494 10 groove groove NN cord-354029-mp5r82g4 494 11 of of IN cord-354029-mp5r82g4 494 12 the the DT cord-354029-mp5r82g4 494 13 central central JJ cord-354029-mp5r82g4 494 14 coiled coil VBN cord-354029-mp5r82g4 494 15 - - HYPH cord-354029-mp5r82g4 494 16 coil coil NN cord-354029-mp5r82g4 494 17 of of IN cord-354029-mp5r82g4 494 18 HIV HIV NNP cord-354029-mp5r82g4 494 19 gp41 gp41 NNP cord-354029-mp5r82g4 494 20 that that WDT cord-354029-mp5r82g4 494 21 is be VBZ cord-354029-mp5r82g4 494 22 important important JJ cord-354029-mp5r82g4 494 23 for for IN cord-354029-mp5r82g4 494 24 interaction interaction NN cord-354029-mp5r82g4 494 25 with with IN cord-354029-mp5r82g4 494 26 the the DT cord-354029-mp5r82g4 494 27 C C NNP cord-354029-mp5r82g4 494 28 - - HYPH cord-354029-mp5r82g4 494 29 terminal terminal NN cord-354029-mp5r82g4 494 30 helix helix NN cord-354029-mp5r82g4 494 31 in in IN cord-354029-mp5r82g4 494 32 the the DT cord-354029-mp5r82g4 494 33 post post JJ cord-354029-mp5r82g4 494 34 - - JJ cord-354029-mp5r82g4 494 35 fusion fusion JJ cord-354029-mp5r82g4 494 36 form form NN cord-354029-mp5r82g4 494 37 . . . cord-354029-mp5r82g4 495 1 In in IN cord-354029-mp5r82g4 495 2 the the DT cord-354029-mp5r82g4 495 3 first first JJ cord-354029-mp5r82g4 495 4 approach approach NN cord-354029-mp5r82g4 495 5 , , , cord-354029-mp5r82g4 495 6 two two CD cord-354029-mp5r82g4 495 7 organic organic JJ cord-354029-mp5r82g4 495 8 compounds compound NNS cord-354029-mp5r82g4 495 9 were be VBD cord-354029-mp5r82g4 495 10 identified identify VBN cord-354029-mp5r82g4 495 11 from from IN cord-354029-mp5r82g4 495 12 a a DT cord-354029-mp5r82g4 495 13 screening screening NN cord-354029-mp5r82g4 495 14 effort effort NN cord-354029-mp5r82g4 495 15 conducted conduct VBN cord-354029-mp5r82g4 495 16 in in IN cord-354029-mp5r82g4 495 17 conjunction conjunction NN cord-354029-mp5r82g4 495 18 with with IN cord-354029-mp5r82g4 495 19 molecular molecular JJ cord-354029-mp5r82g4 495 20 docking docking NN cord-354029-mp5r82g4 495 21 , , , cord-354029-mp5r82g4 495 22 a a DT cord-354029-mp5r82g4 495 23 method method NN cord-354029-mp5r82g4 495 24 to to TO cord-354029-mp5r82g4 495 25 identify identify VB cord-354029-mp5r82g4 495 26 small small JJ cord-354029-mp5r82g4 495 27 molecules molecule NNS cord-354029-mp5r82g4 495 28 that that WDT cord-354029-mp5r82g4 495 29 fit fit VBP cord-354029-mp5r82g4 495 30 in in IN cord-354029-mp5r82g4 495 31 a a DT cord-354029-mp5r82g4 495 32 target target NN cord-354029-mp5r82g4 495 33 site site NN cord-354029-mp5r82g4 495 34 ( ( -LRB- cord-354029-mp5r82g4 495 35 Debnath Debnath NNP cord-354029-mp5r82g4 495 36 et et NNP cord-354029-mp5r82g4 495 37 al al NNP cord-354029-mp5r82g4 495 38 . . . cord-354029-mp5r82g4 495 39 1999 1999 CD cord-354029-mp5r82g4 495 40 ) ) -RRB- cord-354029-mp5r82g4 495 41 . . . cord-354029-mp5r82g4 496 1 The the DT cord-354029-mp5r82g4 496 2 second second JJ cord-354029-mp5r82g4 496 3 approach approach NN cord-354029-mp5r82g4 496 4 replaced replace VBD cord-354029-mp5r82g4 496 5 three three CD cord-354029-mp5r82g4 496 6 residues residue NNS cord-354029-mp5r82g4 496 7 of of IN cord-354029-mp5r82g4 496 8 the the DT cord-354029-mp5r82g4 496 9 C C NNP cord-354029-mp5r82g4 496 10 - - HYPH cord-354029-mp5r82g4 496 11 terminal terminal NN cord-354029-mp5r82g4 496 12 helix helix NN cord-354029-mp5r82g4 496 13 that that WDT cord-354029-mp5r82g4 496 14 bind bind VBP cord-354029-mp5r82g4 496 15 to to IN cord-354029-mp5r82g4 496 16 the the DT cord-354029-mp5r82g4 496 17 hydrophobic hydrophobic JJ cord-354029-mp5r82g4 496 18 pocket pocket NN cord-354029-mp5r82g4 496 19 with with IN cord-354029-mp5r82g4 496 20 organic organic JJ cord-354029-mp5r82g4 496 21 moieties moiety NNS cord-354029-mp5r82g4 496 22 , , , cord-354029-mp5r82g4 496 23 generated generate VBN cord-354029-mp5r82g4 496 24 by by IN cord-354029-mp5r82g4 496 25 combinatorial combinatorial JJ cord-354029-mp5r82g4 496 26 chemistry chemistry NN cord-354029-mp5r82g4 496 27 ( ( -LRB- cord-354029-mp5r82g4 496 28 Ferrer Ferrer NNP cord-354029-mp5r82g4 496 29 et et NNP cord-354029-mp5r82g4 496 30 al al NNP cord-354029-mp5r82g4 496 31 . . . cord-354029-mp5r82g4 496 32 1999 1999 CD cord-354029-mp5r82g4 496 33 ) ) -RRB- cord-354029-mp5r82g4 496 34 . . . cord-354029-mp5r82g4 497 1 The the DT cord-354029-mp5r82g4 497 2 third third JJ cord-354029-mp5r82g4 497 3 approach approach NN cord-354029-mp5r82g4 497 4 used use VBD cord-354029-mp5r82g4 497 5 a a DT cord-354029-mp5r82g4 497 6 mirror mirror NN cord-354029-mp5r82g4 497 7 image image NN cord-354029-mp5r82g4 497 8 phage phage NN cord-354029-mp5r82g4 497 9 display display NN cord-354029-mp5r82g4 497 10 library library NN cord-354029-mp5r82g4 497 11 to to TO cord-354029-mp5r82g4 497 12 identify identify VB cord-354029-mp5r82g4 497 13 small small JJ cord-354029-mp5r82g4 497 14 , , , cord-354029-mp5r82g4 497 15 d d NN cord-354029-mp5r82g4 497 16 - - HYPH cord-354029-mp5r82g4 497 17 amino amino JJ cord-354029-mp5r82g4 497 18 acid acid NN cord-354029-mp5r82g4 497 19 containing contain VBG cord-354029-mp5r82g4 497 20 peptides peptide NNS cord-354029-mp5r82g4 497 21 that that WDT cord-354029-mp5r82g4 497 22 bind bind VBP cord-354029-mp5r82g4 497 23 to to IN cord-354029-mp5r82g4 497 24 the the DT cord-354029-mp5r82g4 497 25 pocket pocket NN cord-354029-mp5r82g4 498 1 ( ( -LRB- cord-354029-mp5r82g4 498 2 Eckert Eckert NNP cord-354029-mp5r82g4 498 3 et et NNP cord-354029-mp5r82g4 498 4 al al NNP cord-354029-mp5r82g4 498 5 . . . cord-354029-mp5r82g4 498 6 1999 1999 CD cord-354029-mp5r82g4 498 7 ) ) -RRB- cord-354029-mp5r82g4 498 8 . . . cord-354029-mp5r82g4 499 1 Although although IN cord-354029-mp5r82g4 499 2 none none NN cord-354029-mp5r82g4 499 3 of of IN cord-354029-mp5r82g4 499 4 the the DT cord-354029-mp5r82g4 499 5 small small JJ cord-354029-mp5r82g4 499 6 molecules molecule NNS cord-354029-mp5r82g4 499 7 identified identify VBN cord-354029-mp5r82g4 499 8 to to IN cord-354029-mp5r82g4 499 9 date date NN cord-354029-mp5r82g4 499 10 is be VBZ cord-354029-mp5r82g4 499 11 as as RB cord-354029-mp5r82g4 499 12 potent potent JJ cord-354029-mp5r82g4 499 13 as as IN cord-354029-mp5r82g4 499 14 T-20 T-20 NNP cord-354029-mp5r82g4 499 15 , , , cord-354029-mp5r82g4 499 16 the the DT cord-354029-mp5r82g4 499 17 precedent precedent NN cord-354029-mp5r82g4 499 18 has have VBZ cord-354029-mp5r82g4 499 19 been be VBN cord-354029-mp5r82g4 499 20 set set VBN cord-354029-mp5r82g4 499 21 for for IN cord-354029-mp5r82g4 499 22 attaining attain VBG cord-354029-mp5r82g4 499 23 this this DT cord-354029-mp5r82g4 499 24 goal goal NN cord-354029-mp5r82g4 499 25 . . . cord-354029-mp5r82g4 500 1 An an DT cord-354029-mp5r82g4 500 2 effort effort NN cord-354029-mp5r82g4 500 3 to to TO cord-354029-mp5r82g4 500 4 block block VB cord-354029-mp5r82g4 500 5 the the DT cord-354029-mp5r82g4 500 6 fusion fusion NN cord-354029-mp5r82g4 500 7 activity activity NN cord-354029-mp5r82g4 500 8 of of IN cord-354029-mp5r82g4 500 9 influenza influenza NN cord-354029-mp5r82g4 500 10 was be VBD cord-354029-mp5r82g4 500 11 based base VBN cord-354029-mp5r82g4 500 12 on on IN cord-354029-mp5r82g4 500 13 the the DT cord-354029-mp5r82g4 500 14 idea idea NN cord-354029-mp5r82g4 500 15 that that IN cord-354029-mp5r82g4 500 16 maintaining maintain VBG cord-354029-mp5r82g4 500 17 HA HA NNP cord-354029-mp5r82g4 500 18 in in IN cord-354029-mp5r82g4 500 19 its -PRON- PRP$ cord-354029-mp5r82g4 500 20 native native JJ cord-354029-mp5r82g4 500 21 metastable metastable JJ cord-354029-mp5r82g4 500 22 state state NN cord-354029-mp5r82g4 500 23 should should MD cord-354029-mp5r82g4 500 24 prevent prevent VB cord-354029-mp5r82g4 500 25 fusion fusion NN cord-354029-mp5r82g4 500 26 and and CC cord-354029-mp5r82g4 500 27 infection infection NN cord-354029-mp5r82g4 500 28 . . . cord-354029-mp5r82g4 501 1 The the DT cord-354029-mp5r82g4 501 2 first first JJ cord-354029-mp5r82g4 501 3 trial trial NN cord-354029-mp5r82g4 501 4 targeted target VBD cord-354029-mp5r82g4 501 5 a a DT cord-354029-mp5r82g4 501 6 site site NN cord-354029-mp5r82g4 501 7 in in IN cord-354029-mp5r82g4 501 8 X:31 X:31 NNP cord-354029-mp5r82g4 501 9 HA HA NNP cord-354029-mp5r82g4 501 10 that that WDT cord-354029-mp5r82g4 501 11 includes include VBZ cord-354029-mp5r82g4 501 12 part part NN cord-354029-mp5r82g4 501 13 of of IN cord-354029-mp5r82g4 501 14 the the DT cord-354029-mp5r82g4 501 15 fusion fusion NN cord-354029-mp5r82g4 501 16 peptide peptide NN cord-354029-mp5r82g4 501 17 . . . cord-354029-mp5r82g4 502 1 With with IN cord-354029-mp5r82g4 502 2 the the DT cord-354029-mp5r82g4 502 3 use use NN cord-354029-mp5r82g4 502 4 of of IN cord-354029-mp5r82g4 502 5 an an DT cord-354029-mp5r82g4 502 6 antibody antibody NN cord-354029-mp5r82g4 502 7 - - HYPH cord-354029-mp5r82g4 502 8 based base VBN cord-354029-mp5r82g4 502 9 assay assay NN cord-354029-mp5r82g4 502 10 to to TO cord-354029-mp5r82g4 502 11 monitor monitor VB cord-354029-mp5r82g4 502 12 fusion fusion NN cord-354029-mp5r82g4 502 13 peptide peptide NN cord-354029-mp5r82g4 502 14 exposure exposure NN cord-354029-mp5r82g4 502 15 , , , cord-354029-mp5r82g4 502 16 a a DT cord-354029-mp5r82g4 502 17 compound compound NN cord-354029-mp5r82g4 502 18 , , , cord-354029-mp5r82g4 502 19 tert tert NN cord-354029-mp5r82g4 502 20 - - HYPH cord-354029-mp5r82g4 502 21 butylhydroquinone butylhydroquinone NNP cord-354029-mp5r82g4 502 22 ( ( -LRB- cord-354029-mp5r82g4 502 23 TBHQ TBHQ NNP cord-354029-mp5r82g4 502 24 ) ) -RRB- cord-354029-mp5r82g4 502 25 , , , cord-354029-mp5r82g4 502 26 that that WDT cord-354029-mp5r82g4 502 27 prevents prevent VBZ cord-354029-mp5r82g4 502 28 the the DT cord-354029-mp5r82g4 502 29 first first JJ cord-354029-mp5r82g4 502 30 stages stage NNS cord-354029-mp5r82g4 502 31 of of IN cord-354029-mp5r82g4 502 32 the the DT cord-354029-mp5r82g4 502 33 HA HA NNP cord-354029-mp5r82g4 502 34 conformational conformational JJ cord-354029-mp5r82g4 502 35 change change NN cord-354029-mp5r82g4 502 36 and and CC cord-354029-mp5r82g4 502 37 inhibits inhibit VBZ cord-354029-mp5r82g4 502 38 infectivity infectivity NN cord-354029-mp5r82g4 502 39 was be VBD cord-354029-mp5r82g4 502 40 discovered discover VBN cord-354029-mp5r82g4 503 1 ( ( -LRB- cord-354029-mp5r82g4 503 2 Bodian Bodian NNP cord-354029-mp5r82g4 503 3 et et NNP cord-354029-mp5r82g4 503 4 al al NNP cord-354029-mp5r82g4 503 5 . . . cord-354029-mp5r82g4 503 6 1993 1993 CD cord-354029-mp5r82g4 503 7 ) ) -RRB- cord-354029-mp5r82g4 503 8 . . . cord-354029-mp5r82g4 504 1 A a DT cord-354029-mp5r82g4 504 2 follow follow VB cord-354029-mp5r82g4 504 3 - - HYPH cord-354029-mp5r82g4 504 4 up up NN cord-354029-mp5r82g4 504 5 study study NN cord-354029-mp5r82g4 504 6 , , , cord-354029-mp5r82g4 504 7 targeting target VBG cord-354029-mp5r82g4 504 8 a a DT cord-354029-mp5r82g4 504 9 site site NN cord-354029-mp5r82g4 504 10 near near IN cord-354029-mp5r82g4 504 11 the the DT cord-354029-mp5r82g4 504 12 B b NN cord-354029-mp5r82g4 504 13 - - HYPH cord-354029-mp5r82g4 504 14 loop loop NN cord-354029-mp5r82g4 504 15 in in IN cord-354029-mp5r82g4 504 16 HA HA NNP cord-354029-mp5r82g4 504 17 , , , cord-354029-mp5r82g4 504 18 yielded yield VBD cord-354029-mp5r82g4 504 19 additional additional JJ cord-354029-mp5r82g4 504 20 inhibitors inhibitor NNS cord-354029-mp5r82g4 504 21 . . . cord-354029-mp5r82g4 505 1 Whereas whereas IN cord-354029-mp5r82g4 505 2 some some DT cord-354029-mp5r82g4 505 3 functioned function VBD cord-354029-mp5r82g4 505 4 like like IN cord-354029-mp5r82g4 505 5 TBHQ TBHQ NNP cord-354029-mp5r82g4 505 6 , , , cord-354029-mp5r82g4 505 7 a a DT cord-354029-mp5r82g4 505 8 second second JJ cord-354029-mp5r82g4 505 9 class class NN cord-354029-mp5r82g4 505 10 was be VBD cord-354029-mp5r82g4 505 11 identified identify VBN cord-354029-mp5r82g4 505 12 that that IN cord-354029-mp5r82g4 505 13 appeared appear VBD cord-354029-mp5r82g4 505 14 to to TO cord-354029-mp5r82g4 505 15 push push VB cord-354029-mp5r82g4 505 16 HA HA NNP cord-354029-mp5r82g4 505 17 to to IN cord-354029-mp5r82g4 505 18 an an DT cord-354029-mp5r82g4 505 19 inactive inactive JJ cord-354029-mp5r82g4 505 20 state state NN cord-354029-mp5r82g4 505 21 ( ( -LRB- cord-354029-mp5r82g4 505 22 Hoffman Hoffman NNP cord-354029-mp5r82g4 505 23 et et NNP cord-354029-mp5r82g4 505 24 al al NNP cord-354029-mp5r82g4 505 25 . . . cord-354029-mp5r82g4 505 26 1997 1997 CD cord-354029-mp5r82g4 505 27 ) ) -RRB- cord-354029-mp5r82g4 505 28 . . . cord-354029-mp5r82g4 506 1 A a DT cord-354029-mp5r82g4 506 2 random random JJ cord-354029-mp5r82g4 506 3 screen screen NN cord-354029-mp5r82g4 506 4 against against IN cord-354029-mp5r82g4 506 5 an an DT cord-354029-mp5r82g4 506 6 H1 H1 NNP cord-354029-mp5r82g4 506 7 influenza influenza NN cord-354029-mp5r82g4 506 8 virus virus NN cord-354029-mp5r82g4 506 9 identified identify VBD cord-354029-mp5r82g4 506 10 an an DT cord-354029-mp5r82g4 506 11 inhibitor inhibitor NN cord-354029-mp5r82g4 506 12 that that WDT cord-354029-mp5r82g4 506 13 appears appear VBZ cord-354029-mp5r82g4 506 14 to to TO cord-354029-mp5r82g4 506 15 function function VB cord-354029-mp5r82g4 506 16 similarly similarly RB cord-354029-mp5r82g4 506 17 to to IN cord-354029-mp5r82g4 506 18 TBHQ TBHQ NNP cord-354029-mp5r82g4 506 19 . . . cord-354029-mp5r82g4 507 1 In in IN cord-354029-mp5r82g4 507 2 the the DT cord-354029-mp5r82g4 507 3 latter latter JJ cord-354029-mp5r82g4 507 4 case case NN cord-354029-mp5r82g4 507 5 , , , cord-354029-mp5r82g4 507 6 the the DT cord-354029-mp5r82g4 507 7 binding binding NN cord-354029-mp5r82g4 507 8 site site NN cord-354029-mp5r82g4 507 9 for for IN cord-354029-mp5r82g4 507 10 the the DT cord-354029-mp5r82g4 507 11 inhibitor inhibitor NN cord-354029-mp5r82g4 507 12 was be VBD cord-354029-mp5r82g4 507 13 mapped map VBN cord-354029-mp5r82g4 507 14 to to IN cord-354029-mp5r82g4 507 15 the the DT cord-354029-mp5r82g4 507 16 vicinity vicinity NN cord-354029-mp5r82g4 507 17 of of IN cord-354029-mp5r82g4 507 18 the the DT cord-354029-mp5r82g4 507 19 fusion fusion NN cord-354029-mp5r82g4 507 20 peptide peptide NN cord-354029-mp5r82g4 508 1 ( ( -LRB- cord-354029-mp5r82g4 508 2 Cianci Cianci NNP cord-354029-mp5r82g4 508 3 et et FW cord-354029-mp5r82g4 508 4 al al NNP cord-354029-mp5r82g4 508 5 . . . cord-354029-mp5r82g4 508 6 1999 1999 CD cord-354029-mp5r82g4 508 7 ) ) -RRB- cord-354029-mp5r82g4 508 8 . . . cord-354029-mp5r82g4 509 1 Other other JJ cord-354029-mp5r82g4 509 2 small small JJ cord-354029-mp5r82g4 509 3 molecules molecule NNS cord-354029-mp5r82g4 509 4 that that WDT cord-354029-mp5r82g4 509 5 inhibit inhibit VBP cord-354029-mp5r82g4 509 6 conformational conformational JJ cord-354029-mp5r82g4 509 7 changes change NNS cord-354029-mp5r82g4 509 8 in in IN cord-354029-mp5r82g4 509 9 HA HA NNP cord-354029-mp5r82g4 509 10 have have VBP cord-354029-mp5r82g4 509 11 been be VBN cord-354029-mp5r82g4 509 12 identified identify VBN cord-354029-mp5r82g4 509 13 ( ( -LRB- cord-354029-mp5r82g4 509 14 Staschke Staschke NNP cord-354029-mp5r82g4 509 15 et et NNP cord-354029-mp5r82g4 509 16 al al NNP cord-354029-mp5r82g4 509 17 . . NNP cord-354029-mp5r82g4 509 18 1998 1998 CD cord-354029-mp5r82g4 509 19 ) ) -RRB- cord-354029-mp5r82g4 509 20 . . . cord-354029-mp5r82g4 510 1 To to IN cord-354029-mp5r82g4 510 2 date date NN cord-354029-mp5r82g4 510 3 , , , cord-354029-mp5r82g4 510 4 none none NN cord-354029-mp5r82g4 510 5 of of IN cord-354029-mp5r82g4 510 6 the the DT cord-354029-mp5r82g4 510 7 HA HA NNP cord-354029-mp5r82g4 510 8 inhibitors inhibitor NNS cord-354029-mp5r82g4 510 9 has have VBZ cord-354029-mp5r82g4 510 10 blocked block VBN cord-354029-mp5r82g4 510 11 all all DT cord-354029-mp5r82g4 510 12 HA HA NNP cord-354029-mp5r82g4 510 13 subtypes subtype NNS cord-354029-mp5r82g4 510 14 and and CC cord-354029-mp5r82g4 510 15 none none NN cord-354029-mp5r82g4 510 16 has have VBZ cord-354029-mp5r82g4 510 17 an an DT cord-354029-mp5r82g4 510 18 IC IC NNP cord-354029-mp5r82g4 510 19 50 50 CD cord-354029-mp5r82g4 510 20 value value NN cord-354029-mp5r82g4 510 21 in in IN cord-354029-mp5r82g4 510 22 the the DT cord-354029-mp5r82g4 510 23 submicromolar submicromolar NNP cord-354029-mp5r82g4 510 24 range range NN cord-354029-mp5r82g4 510 25 . . . cord-354029-mp5r82g4 511 1 It -PRON- PRP cord-354029-mp5r82g4 511 2 is be VBZ cord-354029-mp5r82g4 511 3 not not RB cord-354029-mp5r82g4 511 4 yet yet RB cord-354029-mp5r82g4 511 5 clear clear JJ cord-354029-mp5r82g4 511 6 whether whether IN cord-354029-mp5r82g4 511 7 the the DT cord-354029-mp5r82g4 511 8 latter latter JJ cord-354029-mp5r82g4 511 9 limitation limitation NN cord-354029-mp5r82g4 511 10 represents represent VBZ cord-354029-mp5r82g4 511 11 a a DT cord-354029-mp5r82g4 511 12 fundamental fundamental JJ cord-354029-mp5r82g4 511 13 difficulty difficulty NN cord-354029-mp5r82g4 511 14 in in IN cord-354029-mp5r82g4 511 15 inhibiting inhibit VBG cord-354029-mp5r82g4 511 16 viral viral JJ cord-354029-mp5r82g4 511 17 fusion fusion NN cord-354029-mp5r82g4 511 18 proteins protein NNS cord-354029-mp5r82g4 511 19 that that WDT cord-354029-mp5r82g4 511 20 function function VBP cord-354029-mp5r82g4 511 21 at at IN cord-354029-mp5r82g4 511 22 low low JJ cord-354029-mp5r82g4 511 23 pH. ph. NN cord-354029-mp5r82g4 512 1 In in IN cord-354029-mp5r82g4 512 2 addition addition NN cord-354029-mp5r82g4 512 3 to to IN cord-354029-mp5r82g4 512 4 the the DT cord-354029-mp5r82g4 512 5 small small JJ cord-354029-mp5r82g4 512 6 molecule molecule NN cord-354029-mp5r82g4 512 7 approaches approach NNS cord-354029-mp5r82g4 512 8 described describe VBN cord-354029-mp5r82g4 512 9 above above RB cord-354029-mp5r82g4 512 10 , , , cord-354029-mp5r82g4 512 11 antibodies antibody NNS cord-354029-mp5r82g4 512 12 that that WDT cord-354029-mp5r82g4 512 13 prevent prevent VBP cord-354029-mp5r82g4 512 14 fusion fusion NN cord-354029-mp5r82g4 512 15 - - HYPH cord-354029-mp5r82g4 512 16 inducing induce VBG cord-354029-mp5r82g4 512 17 changes change NNS cord-354029-mp5r82g4 512 18 in in IN cord-354029-mp5r82g4 512 19 viral viral JJ cord-354029-mp5r82g4 512 20 glycoproteins glycoprotein NNS cord-354029-mp5r82g4 512 21 have have VBP cord-354029-mp5r82g4 512 22 been be VBN cord-354029-mp5r82g4 512 23 described describe VBN cord-354029-mp5r82g4 512 24 . . . cord-354029-mp5r82g4 513 1 The the DT cord-354029-mp5r82g4 513 2 first first JJ cord-354029-mp5r82g4 513 3 example example NN cord-354029-mp5r82g4 513 4 was be VBD cord-354029-mp5r82g4 513 5 an an DT cord-354029-mp5r82g4 513 6 antibody antibody NN cord-354029-mp5r82g4 513 7 that that WDT cord-354029-mp5r82g4 513 8 prevents prevent VBZ cord-354029-mp5r82g4 513 9 low low JJ cord-354029-mp5r82g4 513 10 - - HYPH cord-354029-mp5r82g4 513 11 pH ph NN cord-354029-mp5r82g4 513 12 - - HYPH cord-354029-mp5r82g4 513 13 induced induce VBN cord-354029-mp5r82g4 513 14 fusion fusion NN cord-354029-mp5r82g4 513 15 of of IN cord-354029-mp5r82g4 513 16 West West NNP cord-354029-mp5r82g4 513 17 Nile Nile NNP cord-354029-mp5r82g4 513 18 virus virus NN cord-354029-mp5r82g4 513 19 with with IN cord-354029-mp5r82g4 513 20 model model NN cord-354029-mp5r82g4 513 21 liposomes liposome NNS cord-354029-mp5r82g4 513 22 ( ( -LRB- cord-354029-mp5r82g4 513 23 Gollins Gollins NNP cord-354029-mp5r82g4 513 24 and and CC cord-354029-mp5r82g4 513 25 Porterfield Porterfield NNP cord-354029-mp5r82g4 513 26 1986 1986 CD cord-354029-mp5r82g4 513 27 ) ) -RRB- cord-354029-mp5r82g4 513 28 . . . cord-354029-mp5r82g4 514 1 Recently recently RB cord-354029-mp5r82g4 514 2 , , , cord-354029-mp5r82g4 514 3 a a DT cord-354029-mp5r82g4 514 4 Fab Fab NNP cord-354029-mp5r82g4 514 5 fragment fragment NN cord-354029-mp5r82g4 514 6 that that WDT cord-354029-mp5r82g4 514 7 binds bind VBZ cord-354029-mp5r82g4 514 8 to to IN cord-354029-mp5r82g4 514 9 two two CD cord-354029-mp5r82g4 514 10 HA1 HA1 NNP cord-354029-mp5r82g4 514 11 monomers monomer NNS cord-354029-mp5r82g4 514 12 was be VBD cord-354029-mp5r82g4 514 13 shown show VBN cord-354029-mp5r82g4 514 14 to to TO cord-354029-mp5r82g4 514 15 prevent prevent VB cord-354029-mp5r82g4 514 16 an an DT cord-354029-mp5r82g4 514 17 early early JJ cord-354029-mp5r82g4 514 18 conformational conformational JJ cord-354029-mp5r82g4 514 19 change change NN cord-354029-mp5r82g4 514 20 in in IN cord-354029-mp5r82g4 514 21 influenza influenza NN cord-354029-mp5r82g4 514 22 HA HA NNP cord-354029-mp5r82g4 514 23 ( ( -LRB- cord-354029-mp5r82g4 514 24 Barbey- Barbey- NNP cord-354029-mp5r82g4 514 25 Martin Martin NNP cord-354029-mp5r82g4 514 26 et et NNP cord-354029-mp5r82g4 514 27 al al NNP cord-354029-mp5r82g4 514 28 . . . cord-354029-mp5r82g4 514 29 2002 2002 CD cord-354029-mp5r82g4 514 30 ) ) -RRB- cord-354029-mp5r82g4 514 31 , , , cord-354029-mp5r82g4 514 32 separation separation NN cord-354029-mp5r82g4 514 33 of of IN cord-354029-mp5r82g4 514 34 the the DT cord-354029-mp5r82g4 514 35 globular globular JJ cord-354029-mp5r82g4 514 36 head head NN cord-354029-mp5r82g4 514 37 domains domain NNS cord-354029-mp5r82g4 514 38 ( ( -LRB- cord-354029-mp5r82g4 514 39 Fig Fig NNP cord-354029-mp5r82g4 514 40 . . . cord-354029-mp5r82g4 514 41 2B 2b CD cord-354029-mp5r82g4 514 42 ) ) -RRB- cord-354029-mp5r82g4 514 43 . . . cord-354029-mp5r82g4 515 1 As as IN cord-354029-mp5r82g4 515 2 described describe VBN cord-354029-mp5r82g4 515 3 above above RB cord-354029-mp5r82g4 515 4 , , , cord-354029-mp5r82g4 515 5 antibodies antibody NNS cord-354029-mp5r82g4 515 6 have have VBP cord-354029-mp5r82g4 515 7 been be VBN cord-354029-mp5r82g4 515 8 developed develop VBN cord-354029-mp5r82g4 515 9 that that IN cord-354029-mp5r82g4 515 10 likely likely JJ cord-354029-mp5r82g4 515 11 block block VB cord-354029-mp5r82g4 515 12 six six CD cord-354029-mp5r82g4 515 13 - - HYPH cord-354029-mp5r82g4 515 14 helix helix NN cord-354029-mp5r82g4 515 15 bundle bundle NN cord-354029-mp5r82g4 515 16 formation formation NN cord-354029-mp5r82g4 515 17 in in IN cord-354029-mp5r82g4 515 18 the the DT cord-354029-mp5r82g4 515 19 case case NN cord-354029-mp5r82g4 515 20 of of IN cord-354029-mp5r82g4 515 21 HIV HIV NNP cord-354029-mp5r82g4 515 22 Env Env NNP cord-354029-mp5r82g4 515 23 ( ( -LRB- cord-354029-mp5r82g4 515 24 Golding Golding NNP cord-354029-mp5r82g4 515 25 et et NNP cord-354029-mp5r82g4 515 26 al al NNP cord-354029-mp5r82g4 515 27 . . . cord-354029-mp5r82g4 515 28 2002 2002 CD cord-354029-mp5r82g4 515 29 ) ) -RRB- cord-354029-mp5r82g4 515 30 . . . cord-354029-mp5r82g4 516 1 The the DT cord-354029-mp5r82g4 516 2 goal goal NN cord-354029-mp5r82g4 516 3 of of IN cord-354029-mp5r82g4 516 4 this this DT cord-354029-mp5r82g4 516 5 review review NN cord-354029-mp5r82g4 516 6 was be VBD cord-354029-mp5r82g4 516 7 to to TO cord-354029-mp5r82g4 516 8 give give VB cord-354029-mp5r82g4 516 9 the the DT cord-354029-mp5r82g4 516 10 reader reader NN cord-354029-mp5r82g4 516 11 an an DT cord-354029-mp5r82g4 516 12 appreciation appreciation NN cord-354029-mp5r82g4 516 13 for for IN cord-354029-mp5r82g4 516 14 the the DT cord-354029-mp5r82g4 516 15 diversity diversity NN cord-354029-mp5r82g4 516 16 of of IN cord-354029-mp5r82g4 516 17 viral viral JJ cord-354029-mp5r82g4 516 18 fusion fusion NN cord-354029-mp5r82g4 516 19 mechanisms mechanism NNS cord-354029-mp5r82g4 516 20 while while IN cord-354029-mp5r82g4 516 21 recognizing recognize VBG cord-354029-mp5r82g4 516 22 their -PRON- PRP$ cord-354029-mp5r82g4 516 23 common common JJ cord-354029-mp5r82g4 516 24 underlying underlying JJ cord-354029-mp5r82g4 516 25 principles principle NNS cord-354029-mp5r82g4 516 26 . . . cord-354029-mp5r82g4 517 1 We -PRON- PRP cord-354029-mp5r82g4 517 2 also also RB cord-354029-mp5r82g4 517 3 summarized summarize VBD cord-354029-mp5r82g4 517 4 what what WP cord-354029-mp5r82g4 517 5 is be VBZ cord-354029-mp5r82g4 517 6 known know VBN cord-354029-mp5r82g4 517 7 about about IN cord-354029-mp5r82g4 517 8 the the DT cord-354029-mp5r82g4 517 9 lipid lipid NN cord-354029-mp5r82g4 517 10 dynamics dynamic NNS cord-354029-mp5r82g4 517 11 and and CC cord-354029-mp5r82g4 517 12 lipid lipid NN cord-354029-mp5r82g4 517 13 structures structure NNS cord-354029-mp5r82g4 517 14 involved involve VBN cord-354029-mp5r82g4 517 15 in in IN cord-354029-mp5r82g4 517 16 fusion fusion NN cord-354029-mp5r82g4 517 17 , , , cord-354029-mp5r82g4 517 18 and and CC cord-354029-mp5r82g4 517 19 we -PRON- PRP cord-354029-mp5r82g4 517 20 also also RB cord-354029-mp5r82g4 517 21 briefly briefly RB cord-354029-mp5r82g4 517 22 overviewed overviewe VBD cord-354029-mp5r82g4 517 23 recent recent JJ cord-354029-mp5r82g4 517 24 developments development NNS cord-354029-mp5r82g4 517 25 in in IN cord-354029-mp5r82g4 517 26 targeting target VBG cord-354029-mp5r82g4 517 27 viral viral JJ cord-354029-mp5r82g4 517 28 fusion fusion NN cord-354029-mp5r82g4 517 29 as as IN cord-354029-mp5r82g4 517 30 an an DT cord-354029-mp5r82g4 517 31 antiviral antiviral JJ cord-354029-mp5r82g4 517 32 strategy strategy NN cord-354029-mp5r82g4 517 33 . . . cord-354029-mp5r82g4 518 1 There there EX cord-354029-mp5r82g4 518 2 is be VBZ cord-354029-mp5r82g4 518 3 clearly clearly RB cord-354029-mp5r82g4 518 4 much much RB cord-354029-mp5r82g4 518 5 more more RBR cord-354029-mp5r82g4 518 6 we -PRON- PRP cord-354029-mp5r82g4 518 7 need need VBP cord-354029-mp5r82g4 518 8 to to TO cord-354029-mp5r82g4 518 9 know know VB cord-354029-mp5r82g4 518 10 about about IN cord-354029-mp5r82g4 518 11 viral viral JJ cord-354029-mp5r82g4 518 12 fusion fusion NN cord-354029-mp5r82g4 518 13 proteins protein NNS cord-354029-mp5r82g4 518 14 , , , cord-354029-mp5r82g4 518 15 viral viral JJ cord-354029-mp5r82g4 518 16 fusion fusion NN cord-354029-mp5r82g4 518 17 reactions reaction NNS cord-354029-mp5r82g4 518 18 , , , cord-354029-mp5r82g4 518 19 and and CC cord-354029-mp5r82g4 518 20 the the DT cord-354029-mp5r82g4 518 21 design design NN cord-354029-mp5r82g4 518 22 of of IN cord-354029-mp5r82g4 518 23 antifusion antifusion NN cord-354029-mp5r82g4 518 24 agents agent NNS cord-354029-mp5r82g4 518 25 . . . cord-354029-mp5r82g4 519 1 We -PRON- PRP cord-354029-mp5r82g4 519 2 end end VBP cord-354029-mp5r82g4 519 3 this this DT cord-354029-mp5r82g4 519 4 review review NN cord-354029-mp5r82g4 519 5 by by IN cord-354029-mp5r82g4 519 6 enumerating enumerate VBG cord-354029-mp5r82g4 519 7 some some DT cord-354029-mp5r82g4 519 8 pressing press VBG cord-354029-mp5r82g4 519 9 issues issue NNS cord-354029-mp5r82g4 519 10 and and CC cord-354029-mp5r82g4 519 11 questions question NNS cord-354029-mp5r82g4 519 12 that that WDT cord-354029-mp5r82g4 519 13 remain remain VBP cord-354029-mp5r82g4 519 14 about about IN cord-354029-mp5r82g4 519 15 viral viral JJ cord-354029-mp5r82g4 519 16 fusion fusion NN cord-354029-mp5r82g4 519 17 . . . cord-354029-mp5r82g4 520 1 A a DT cord-354029-mp5r82g4 520 2 major major JJ cord-354029-mp5r82g4 520 3 goal goal NN cord-354029-mp5r82g4 520 4 is be VBZ cord-354029-mp5r82g4 520 5 to to TO cord-354029-mp5r82g4 520 6 determine determine VB cord-354029-mp5r82g4 520 7 highresolution highresolution NN cord-354029-mp5r82g4 520 8 structures structure NNS cord-354029-mp5r82g4 520 9 for for IN cord-354029-mp5r82g4 520 10 the the DT cord-354029-mp5r82g4 520 11 complete complete JJ cord-354029-mp5r82g4 520 12 ectodomains ectodomain NNS cord-354029-mp5r82g4 520 13 of of IN cord-354029-mp5r82g4 520 14 the the DT cord-354029-mp5r82g4 520 15 metastable metastable JJ cord-354029-mp5r82g4 520 16 trimers trimer NNS cord-354029-mp5r82g4 520 17 of of IN cord-354029-mp5r82g4 520 18 class class NN cord-354029-mp5r82g4 520 19 I -PRON- PRP cord-354029-mp5r82g4 520 20 viral viral JJ cord-354029-mp5r82g4 520 21 fusion fusion NN cord-354029-mp5r82g4 520 22 proteins protein NNS cord-354029-mp5r82g4 520 23 in in IN cord-354029-mp5r82g4 520 24 addition addition NN cord-354029-mp5r82g4 520 25 to to IN cord-354029-mp5r82g4 520 26 the the DT cord-354029-mp5r82g4 520 27 influenza influenza NN cord-354029-mp5r82g4 520 28 HA HA NNP cord-354029-mp5r82g4 520 29 . . . cord-354029-mp5r82g4 521 1 Structures structure NNS cord-354029-mp5r82g4 521 2 of of IN cord-354029-mp5r82g4 521 3 a a DT cord-354029-mp5r82g4 521 4 complete complete JJ cord-354029-mp5r82g4 521 5 paramyxovirus paramyxovirus JJ cord-354029-mp5r82g4 521 6 F f NN cord-354029-mp5r82g4 521 7 and and CC cord-354029-mp5r82g4 521 8 a a DT cord-354029-mp5r82g4 521 9 complete complete JJ cord-354029-mp5r82g4 521 10 retroviral retroviral NN cord-354029-mp5r82g4 521 11 Env env NN cord-354029-mp5r82g4 521 12 ectodomain ectodomain NN cord-354029-mp5r82g4 521 13 will will MD cord-354029-mp5r82g4 521 14 be be VB cord-354029-mp5r82g4 521 15 highly highly RB cord-354029-mp5r82g4 521 16 informative informative JJ cord-354029-mp5r82g4 521 17 because because IN cord-354029-mp5r82g4 521 18 we -PRON- PRP cord-354029-mp5r82g4 521 19 currently currently RB cord-354029-mp5r82g4 521 20 lack lack VBP cord-354029-mp5r82g4 521 21 a a DT cord-354029-mp5r82g4 521 22 detailed detailed JJ cord-354029-mp5r82g4 521 23 molecular molecular JJ cord-354029-mp5r82g4 521 24 description description NN cord-354029-mp5r82g4 521 25 of of IN cord-354029-mp5r82g4 521 26 how how WRB cord-354029-mp5r82g4 521 27 a a DT cord-354029-mp5r82g4 521 28 receptor receptor NN cord-354029-mp5r82g4 521 29 activates activate VBZ cord-354029-mp5r82g4 521 30 any any DT cord-354029-mp5r82g4 521 31 viral viral JJ cord-354029-mp5r82g4 521 32 fusion fusion NN cord-354029-mp5r82g4 521 33 protein protein NN cord-354029-mp5r82g4 521 34 at at IN cord-354029-mp5r82g4 521 35 neutral neutral JJ cord-354029-mp5r82g4 521 36 pH. pH. NNP cord-354029-mp5r82g4 521 37 A a DT cord-354029-mp5r82g4 521 38 second second JJ cord-354029-mp5r82g4 521 39 goal goal NN cord-354029-mp5r82g4 521 40 will will MD cord-354029-mp5r82g4 521 41 be be VB cord-354029-mp5r82g4 521 42 to to TO cord-354029-mp5r82g4 521 43 further further RB cord-354029-mp5r82g4 521 44 delineate delineate VB cord-354029-mp5r82g4 521 45 the the DT cord-354029-mp5r82g4 521 46 mechanisms mechanism NNS cord-354029-mp5r82g4 521 47 of of IN cord-354029-mp5r82g4 521 48 class class NN cord-354029-mp5r82g4 521 49 II ii CD cord-354029-mp5r82g4 521 50 viral viral JJ cord-354029-mp5r82g4 521 51 fusion fusion NN cord-354029-mp5r82g4 521 52 proteins protein NNS cord-354029-mp5r82g4 521 53 . . . cord-354029-mp5r82g4 522 1 Do do VBP cord-354029-mp5r82g4 522 2 the the DT cord-354029-mp5r82g4 522 3 transitions transition NNS cord-354029-mp5r82g4 522 4 to to IN cord-354029-mp5r82g4 522 5 their -PRON- PRP$ cord-354029-mp5r82g4 522 6 recently recently RB cord-354029-mp5r82g4 522 7 described describe VBN cord-354029-mp5r82g4 522 8 low low JJ cord-354029-mp5r82g4 522 9 pH pH NNP cord-354029-mp5r82g4 522 10 forms form NNS cord-354029-mp5r82g4 522 11 ( ( -LRB- cord-354029-mp5r82g4 522 12 Bressanelli Bressanelli NNP cord-354029-mp5r82g4 522 13 et et NNP cord-354029-mp5r82g4 522 14 al al NNP cord-354029-mp5r82g4 522 15 . . . cord-354029-mp5r82g4 522 16 2004 2004 CD cord-354029-mp5r82g4 522 17 ; ; : cord-354029-mp5r82g4 522 18 Gibbons Gibbons NNP cord-354029-mp5r82g4 522 19 et et NNP cord-354029-mp5r82g4 522 20 al al NNP cord-354029-mp5r82g4 522 21 . . . cord-354029-mp5r82g4 522 22 2004 2004 CD cord-354029-mp5r82g4 522 23 ; ; : cord-354029-mp5r82g4 522 24 Modis Modis NNP cord-354029-mp5r82g4 522 25 et et NNP cord-354029-mp5r82g4 522 26 al al NNP cord-354029-mp5r82g4 522 27 . . . cord-354029-mp5r82g4 522 28 2004 2004 CD cord-354029-mp5r82g4 522 29 ) ) -RRB- cord-354029-mp5r82g4 522 30 mediate mediate VB cord-354029-mp5r82g4 522 31 hemifusion hemifusion NN cord-354029-mp5r82g4 522 32 or or CC cord-354029-mp5r82g4 522 33 fusion fusion NN cord-354029-mp5r82g4 522 34 pore pore NN cord-354029-mp5r82g4 522 35 opening opening NN cord-354029-mp5r82g4 522 36 ? ? . cord-354029-mp5r82g4 523 1 What what WP cord-354029-mp5r82g4 523 2 about about IN cord-354029-mp5r82g4 523 3 the the DT cord-354029-mp5r82g4 523 4 mechanisms mechanism NNS cord-354029-mp5r82g4 523 5 of of IN cord-354029-mp5r82g4 523 6 the the DT cord-354029-mp5r82g4 523 7 as as RB cord-354029-mp5r82g4 523 8 yet yet RB cord-354029-mp5r82g4 523 9 unclassified unclassified JJ cord-354029-mp5r82g4 523 10 viral viral JJ cord-354029-mp5r82g4 523 11 fusion fusion NN cord-354029-mp5r82g4 523 12 proteins protein NNS cord-354029-mp5r82g4 523 13 ? ? . cord-354029-mp5r82g4 524 1 These these DT cord-354029-mp5r82g4 524 2 include include VBP cord-354029-mp5r82g4 524 3 viruses virus NNS cord-354029-mp5r82g4 524 4 such such JJ cord-354029-mp5r82g4 524 5 as as IN cord-354029-mp5r82g4 524 6 rhabdoviruses rhabdovirus NNS cord-354029-mp5r82g4 524 7 ( ( -LRB- cord-354029-mp5r82g4 524 8 e.g. e.g. RB cord-354029-mp5r82g4 524 9 , , , cord-354029-mp5r82g4 524 10 VSV VSV NNP cord-354029-mp5r82g4 524 11 ) ) -RRB- cord-354029-mp5r82g4 524 12 that that WDT cord-354029-mp5r82g4 524 13 need need VBP cord-354029-mp5r82g4 524 14 only only RB cord-354029-mp5r82g4 524 15 one one CD cord-354029-mp5r82g4 524 16 protein protein NN cord-354029-mp5r82g4 524 17 to to TO cord-354029-mp5r82g4 524 18 promote promote VB cord-354029-mp5r82g4 524 19 fusion fusion NN cord-354029-mp5r82g4 524 20 , , , cord-354029-mp5r82g4 524 21 as as RB cord-354029-mp5r82g4 524 22 well well RB cord-354029-mp5r82g4 524 23 as as IN cord-354029-mp5r82g4 524 24 more more RBR cord-354029-mp5r82g4 524 25 complicated complicated JJ cord-354029-mp5r82g4 524 26 viruses virus NNS cord-354029-mp5r82g4 524 27 such such JJ cord-354029-mp5r82g4 524 28 as as IN cord-354029-mp5r82g4 524 29 herpesviruses herpesviruses NNP cord-354029-mp5r82g4 524 30 and and CC cord-354029-mp5r82g4 524 31 poxviruses poxvirus NNS cord-354029-mp5r82g4 524 32 that that WDT cord-354029-mp5r82g4 524 33 require require VBP cord-354029-mp5r82g4 524 34 multiple multiple JJ cord-354029-mp5r82g4 524 35 viral viral JJ cord-354029-mp5r82g4 524 36 glycoproteins glycoprotein NNS cord-354029-mp5r82g4 524 37 . . . cord-354029-mp5r82g4 525 1 The the DT cord-354029-mp5r82g4 525 2 ensuing ensue VBG cord-354029-mp5r82g4 525 3 years year NNS cord-354029-mp5r82g4 525 4 should should MD cord-354029-mp5r82g4 525 5 also also RB cord-354029-mp5r82g4 525 6 bring bring VB cord-354029-mp5r82g4 525 7 a a DT cord-354029-mp5r82g4 525 8 more more RBR cord-354029-mp5r82g4 525 9 complete complete JJ cord-354029-mp5r82g4 525 10 understanding understanding NN cord-354029-mp5r82g4 525 11 of of IN cord-354029-mp5r82g4 525 12 how how WRB cord-354029-mp5r82g4 525 13 viral viral JJ cord-354029-mp5r82g4 525 14 fusion fusion NN cord-354029-mp5r82g4 525 15 proteins protein NNS cord-354029-mp5r82g4 525 16 interact interact VBP cord-354029-mp5r82g4 525 17 with with IN cord-354029-mp5r82g4 525 18 target target NN cord-354029-mp5r82g4 525 19 membrane membrane NN cord-354029-mp5r82g4 525 20 bilayers bilayer NNS cord-354029-mp5r82g4 525 21 . . . cord-354029-mp5r82g4 526 1 Class class NN cord-354029-mp5r82g4 526 2 II II NNP cord-354029-mp5r82g4 526 3 fusion fusion NN cord-354029-mp5r82g4 526 4 proteins protein NNS cord-354029-mp5r82g4 526 5 insert insert VBP cord-354029-mp5r82g4 526 6 their -PRON- PRP$ cord-354029-mp5r82g4 526 7 internal internal JJ cord-354029-mp5r82g4 526 8 fusion fusion NN cord-354029-mp5r82g4 526 9 peptides peptide NNS cord-354029-mp5r82g4 526 10 into into IN cord-354029-mp5r82g4 526 11 target target NN cord-354029-mp5r82g4 526 12 membranes membrane NNS cord-354029-mp5r82g4 526 13 as as IN cord-354029-mp5r82g4 526 14 loops loop NNS cord-354029-mp5r82g4 526 15 ( ( -LRB- cord-354029-mp5r82g4 526 16 Bressanelli Bressanelli NNP cord-354029-mp5r82g4 526 17 et et NNP cord-354029-mp5r82g4 526 18 al al NNP cord-354029-mp5r82g4 526 19 . . . cord-354029-mp5r82g4 527 1 2004 2004 CD cord-354029-mp5r82g4 527 2 ; ; : cord-354029-mp5r82g4 527 3 Gibbons Gibbons NNP cord-354029-mp5r82g4 527 4 et et NNP cord-354029-mp5r82g4 527 5 al al NNP cord-354029-mp5r82g4 527 6 . . . cord-354029-mp5r82g4 528 1 2004 2004 CD cord-354029-mp5r82g4 528 2 ; ; : cord-354029-mp5r82g4 528 3 Modis Modis NNP cord-354029-mp5r82g4 528 4 et et NNP cord-354029-mp5r82g4 528 5 al al NNP cord-354029-mp5r82g4 528 6 . . . cord-354029-mp5r82g4 528 7 2004 2004 CD cord-354029-mp5r82g4 528 8 ) ) -RRB- cord-354029-mp5r82g4 528 9 . . . cord-354029-mp5r82g4 529 1 It -PRON- PRP cord-354029-mp5r82g4 529 2 has have VBZ cord-354029-mp5r82g4 529 3 been be VBN cord-354029-mp5r82g4 529 4 predicted predict VBN cord-354029-mp5r82g4 529 5 that that IN cord-354029-mp5r82g4 529 6 the the DT cord-354029-mp5r82g4 529 7 internal internal JJ cord-354029-mp5r82g4 529 8 fusion fusion NN cord-354029-mp5r82g4 529 9 proteins protein NNS cord-354029-mp5r82g4 529 10 of of IN cord-354029-mp5r82g4 529 11 the the DT cord-354029-mp5r82g4 529 12 class class NN cord-354029-mp5r82g4 529 13 I -PRON- PRP cord-354029-mp5r82g4 529 14 fusion fusion NN cord-354029-mp5r82g4 529 15 proteins protein NNS cord-354029-mp5r82g4 529 16 from from IN cord-354029-mp5r82g4 529 17 Ebola Ebola NNP cord-354029-mp5r82g4 529 18 and and CC cord-354029-mp5r82g4 529 19 avian avian JJ cord-354029-mp5r82g4 529 20 retroviruses retrovirus NNS cord-354029-mp5r82g4 529 21 form form VBP cord-354029-mp5r82g4 529 22 disulfidebonded disulfidebonde VBN cord-354029-mp5r82g4 529 23 loop loop NN cord-354029-mp5r82g4 529 24 structures structure NNS cord-354029-mp5r82g4 529 25 ( ( -LRB- cord-354029-mp5r82g4 529 26 Weisenhorn Weisenhorn NNP cord-354029-mp5r82g4 529 27 et et NNP cord-354029-mp5r82g4 529 28 al al NNP cord-354029-mp5r82g4 529 29 . . NNP cord-354029-mp5r82g4 529 30 1998 1998 CD cord-354029-mp5r82g4 529 31 ) ) -RRB- cord-354029-mp5r82g4 529 32 , , , cord-354029-mp5r82g4 529 33 and and CC cord-354029-mp5r82g4 529 34 mutagenesis mutagenesis NN cord-354029-mp5r82g4 529 35 work work NN cord-354029-mp5r82g4 529 36 has have VBZ cord-354029-mp5r82g4 529 37 supported support VBN cord-354029-mp5r82g4 529 38 this this DT cord-354029-mp5r82g4 529 39 prediction prediction NN cord-354029-mp5r82g4 529 40 Jeffers Jeffers NNP cord-354029-mp5r82g4 529 41 et et NNP cord-354029-mp5r82g4 529 42 al al NNP cord-354029-mp5r82g4 529 43 . . . cord-354029-mp5r82g4 529 44 2002 2002 CD cord-354029-mp5r82g4 529 45 ) ) -RRB- cord-354029-mp5r82g4 529 46 . . . cord-354029-mp5r82g4 530 1 It -PRON- PRP cord-354029-mp5r82g4 530 2 remains remain VBZ cord-354029-mp5r82g4 530 3 to to TO cord-354029-mp5r82g4 530 4 be be VB cord-354029-mp5r82g4 530 5 seen see VBN cord-354029-mp5r82g4 530 6 , , , cord-354029-mp5r82g4 530 7 from from IN cord-354029-mp5r82g4 530 8 high high JJ cord-354029-mp5r82g4 530 9 resolution resolution NN cord-354029-mp5r82g4 530 10 structural structural JJ cord-354029-mp5r82g4 530 11 studies study NNS cord-354029-mp5r82g4 530 12 , , , cord-354029-mp5r82g4 530 13 whether whether IN cord-354029-mp5r82g4 530 14 all all DT cord-354029-mp5r82g4 530 15 internal internal JJ cord-354029-mp5r82g4 530 16 fusion fusion NN cord-354029-mp5r82g4 530 17 peptides peptide NNS cord-354029-mp5r82g4 530 18 , , , cord-354029-mp5r82g4 530 19 be be VB cord-354029-mp5r82g4 530 20 they -PRON- PRP cord-354029-mp5r82g4 530 21 from from IN cord-354029-mp5r82g4 530 22 class class NN cord-354029-mp5r82g4 530 23 I i NN cord-354029-mp5r82g4 530 24 , , , cord-354029-mp5r82g4 530 25 class class NN cord-354029-mp5r82g4 530 26 II II NNP cord-354029-mp5r82g4 530 27 , , , cord-354029-mp5r82g4 530 28 or or CC cord-354029-mp5r82g4 530 29 other other JJ cord-354029-mp5r82g4 530 30 classes class NNS cord-354029-mp5r82g4 530 31 of of IN cord-354029-mp5r82g4 530 32 fusion fusion NN cord-354029-mp5r82g4 530 33 proteins protein NNS cord-354029-mp5r82g4 530 34 , , , cord-354029-mp5r82g4 530 35 interact interact VBP cord-354029-mp5r82g4 530 36 with with IN cord-354029-mp5r82g4 530 37 target target NN cord-354029-mp5r82g4 530 38 bilayers bilayer NNS cord-354029-mp5r82g4 530 39 as as IN cord-354029-mp5r82g4 530 40 ( ( -LRB- cord-354029-mp5r82g4 530 41 disulfide disulfide JJ cord-354029-mp5r82g4 530 42 bond bond NN cord-354029-mp5r82g4 530 43 ) ) -RRB- cord-354029-mp5r82g4 530 44 stabilized stabilize VBD cord-354029-mp5r82g4 530 45 loops loop NNS cord-354029-mp5r82g4 530 46 . . . cord-354029-mp5r82g4 531 1 Finally finally RB cord-354029-mp5r82g4 531 2 , , , cord-354029-mp5r82g4 531 3 we -PRON- PRP cord-354029-mp5r82g4 531 4 expect expect VBP cord-354029-mp5r82g4 531 5 that that IN cord-354029-mp5r82g4 531 6 there there EX cord-354029-mp5r82g4 531 7 will will MD cord-354029-mp5r82g4 531 8 be be VB cord-354029-mp5r82g4 531 9 major major JJ cord-354029-mp5r82g4 531 10 developments development NNS cord-354029-mp5r82g4 531 11 in in IN cord-354029-mp5r82g4 531 12 furthering further VBG cord-354029-mp5r82g4 531 13 the the DT cord-354029-mp5r82g4 531 14 concept concept NN cord-354029-mp5r82g4 531 15 of of IN cord-354029-mp5r82g4 531 16 targeting target VBG cord-354029-mp5r82g4 531 17 fusion fusion NN cord-354029-mp5r82g4 531 18 as as IN cord-354029-mp5r82g4 531 19 a a DT cord-354029-mp5r82g4 531 20 weapon weapon NN cord-354029-mp5r82g4 531 21 against against IN cord-354029-mp5r82g4 531 22 pathogenic pathogenic JJ cord-354029-mp5r82g4 531 23 enveloped envelop VBN cord-354029-mp5r82g4 531 24 viruses virus NNS cord-354029-mp5r82g4 531 25 . . . cord-354029-mp5r82g4 532 1 Particular particular JJ cord-354029-mp5r82g4 532 2 emphasis emphasis NN cord-354029-mp5r82g4 532 3 will will MD cord-354029-mp5r82g4 532 4 likely likely RB cord-354029-mp5r82g4 532 5 be be VB cord-354029-mp5r82g4 532 6 on on IN cord-354029-mp5r82g4 532 7 the the DT cord-354029-mp5r82g4 532 8 development development NN cord-354029-mp5r82g4 532 9 of of IN cord-354029-mp5r82g4 532 10 small small JJ cord-354029-mp5r82g4 532 11 molecule molecule NN cord-354029-mp5r82g4 532 12 inhibitors inhibitor NNS cord-354029-mp5r82g4 532 13 through through IN cord-354029-mp5r82g4 532 14 the the DT cord-354029-mp5r82g4 532 15 use use NN cord-354029-mp5r82g4 532 16 of of IN cord-354029-mp5r82g4 532 17 combinatorial combinatorial JJ cord-354029-mp5r82g4 532 18 chemistry chemistry NN cord-354029-mp5r82g4 532 19 in in IN cord-354029-mp5r82g4 532 20 conjunction conjunction NN cord-354029-mp5r82g4 532 21 with with IN cord-354029-mp5r82g4 532 22 high high JJ cord-354029-mp5r82g4 532 23 - - HYPH cord-354029-mp5r82g4 532 24 throughput throughput NN cord-354029-mp5r82g4 532 25 screens screen NNS cord-354029-mp5r82g4 532 26 . . . cord-354029-mp5r82g4 533 1 It -PRON- PRP cord-354029-mp5r82g4 533 2 will will MD cord-354029-mp5r82g4 533 3 be be VB cord-354029-mp5r82g4 533 4 interesting interesting JJ cord-354029-mp5r82g4 533 5 to to TO cord-354029-mp5r82g4 533 6 learn learn VB cord-354029-mp5r82g4 533 7 whether whether IN cord-354029-mp5r82g4 533 8 small small JJ cord-354029-mp5r82g4 533 9 molecule molecule NN cord-354029-mp5r82g4 533 10 fusion fusion NN cord-354029-mp5r82g4 533 11 inhibitors inhibitor NNS cord-354029-mp5r82g4 533 12 can can MD cord-354029-mp5r82g4 533 13 be be VB cord-354029-mp5r82g4 533 14 identified identify VBN cord-354029-mp5r82g4 533 15 that that DT cord-354029-mp5r82g4 533 16 block block VBP cord-354029-mp5r82g4 533 17 the the DT cord-354029-mp5r82g4 533 18 entry entry NN cord-354029-mp5r82g4 533 19 of of IN cord-354029-mp5r82g4 533 20 viruses virus NNS cord-354029-mp5r82g4 533 21 that that WDT cord-354029-mp5r82g4 533 22 fuse fuse VBP cord-354029-mp5r82g4 533 23 in in IN cord-354029-mp5r82g4 533 24 endosomes endosome NNS cord-354029-mp5r82g4 533 25 in in IN cord-354029-mp5r82g4 533 26 response response NN cord-354029-mp5r82g4 533 27 to to IN cord-354029-mp5r82g4 533 28 low low JJ cord-354029-mp5r82g4 533 29 pH. ph. NN cord-354029-mp5r82g4 534 1 This this DT cord-354029-mp5r82g4 534 2 is be VBZ cord-354029-mp5r82g4 534 3 a a DT cord-354029-mp5r82g4 534 4 challenge challenge NN cord-354029-mp5r82g4 534 5 for for IN cord-354029-mp5r82g4 534 6 low low JJ cord-354029-mp5r82g4 534 7 - - HYPH cord-354029-mp5r82g4 534 8 pH ph NN cord-354029-mp5r82g4 534 9 - - HYPH cord-354029-mp5r82g4 534 10 activated activate VBN cord-354029-mp5r82g4 534 11 class class NN cord-354029-mp5r82g4 534 12 I -PRON- PRP cord-354029-mp5r82g4 534 13 fusion fusion NN cord-354029-mp5r82g4 534 14 proteins protein NNS cord-354029-mp5r82g4 534 15 such such JJ cord-354029-mp5r82g4 534 16 as as IN cord-354029-mp5r82g4 534 17 influenza influenza NN cord-354029-mp5r82g4 534 18 HA HA NNP cord-354029-mp5r82g4 534 19 as as RB cord-354029-mp5r82g4 534 20 well well RB cord-354029-mp5r82g4 534 21 as as IN cord-354029-mp5r82g4 534 22 for for IN cord-354029-mp5r82g4 534 23 all all DT cord-354029-mp5r82g4 534 24 known know VBN cord-354029-mp5r82g4 534 25 class class NN cord-354029-mp5r82g4 534 26 II II NNP cord-354029-mp5r82g4 534 27 fusion fusion NN cord-354029-mp5r82g4 534 28 proteins protein NNS cord-354029-mp5r82g4 534 29 . . . cord-354029-mp5r82g4 535 1 Stay stay VB cord-354029-mp5r82g4 535 2 tuned tune VBN cord-354029-mp5r82g4 535 3 . . . cord-354029-mp5r82g4 536 1 There there EX cord-354029-mp5r82g4 536 2 are be VBP cord-354029-mp5r82g4 536 3 likely likely JJ cord-354029-mp5r82g4 536 4 to to TO cord-354029-mp5r82g4 536 5 be be VB cord-354029-mp5r82g4 536 6 exciting exciting JJ cord-354029-mp5r82g4 536 7 develop develop NNS cord-354029-mp5r82g4 536 8 - - HYPH cord-354029-mp5r82g4 536 9 ments ment NNS cord-354029-mp5r82g4 536 10 in in IN cord-354029-mp5r82g4 536 11 our -PRON- PRP$ cord-354029-mp5r82g4 536 12 understanding understanding NN cord-354029-mp5r82g4 536 13 of of IN cord-354029-mp5r82g4 536 14 viral viral JJ cord-354029-mp5r82g4 536 15 fusion fusion NN cord-354029-mp5r82g4 536 16 mechanisms mechanism NNS cord-354029-mp5r82g4 536 17 as as RB cord-354029-mp5r82g4 536 18 well well RB cord-354029-mp5r82g4 536 19 as as IN cord-354029-mp5r82g4 536 20 in in IN cord-354029-mp5r82g4 536 21 the the DT cord-354029-mp5r82g4 536 22 development development NN cord-354029-mp5r82g4 536 23 of of IN cord-354029-mp5r82g4 536 24 antifusion antifusion NN cord-354029-mp5r82g4 536 25 antivirals antiviral NNS cord-354029-mp5r82g4 536 26 in in IN cord-354029-mp5r82g4 536 27 the the DT cord-354029-mp5r82g4 536 28 years year NNS cord-354029-mp5r82g4 536 29 ahead ahead RB cord-354029-mp5r82g4 536 30 . . . cord-354029-mp5r82g4 537 1 Dennison Dennison NNP cord-354029-mp5r82g4 537 2 SM SM NNP cord-354029-mp5r82g4 537 3 , , , cord-354029-mp5r82g4 537 4 Greenfield Greenfield NNP cord-354029-mp5r82g4 537 5 N N NNP cord-354029-mp5r82g4 537 6 , , , cord-354029-mp5r82g4 537 7 Lenard Lenard NNP cord-354029-mp5r82g4 537 8 J J NNP cord-354029-mp5r82g4 537 9 , , , cord-354029-mp5r82g4 537 10 and and CC cord-354029-mp5r82g4 537 11 Lentz Lentz NNP cord-354029-mp5r82g4 537 12 BR BR NNP cord-354029-mp5r82g4 537 13 ( ( -LRB- cord-354029-mp5r82g4 537 14 2002 2002 CD cord-354029-mp5r82g4 537 15 ) ) -RRB- cord-354029-mp5r82g4 537 16 _SP cord-354029-mp5r82g4 538 1 Receptor receptor NN cord-354029-mp5r82g4 538 2 binding binding NN cord-354029-mp5r82g4 538 3 transforms transform VBZ cord-354029-mp5r82g4 538 4 the the DT cord-354029-mp5r82g4 538 5 surface surface NN cord-354029-mp5r82g4 538 6 subunit subunit NN cord-354029-mp5r82g4 538 7 of of IN cord-354029-mp5r82g4 538 8 the the DT cord-354029-mp5r82g4 538 9 mammalian mammalian JJ cord-354029-mp5r82g4 538 10 C c NN cord-354029-mp5r82g4 538 11 - - HYPH cord-354029-mp5r82g4 538 12 type type NN cord-354029-mp5r82g4 538 13 retrovirus retrovirus NN cord-354029-mp5r82g4 538 14 envelope envelope NN cord-354029-mp5r82g4 538 15 protein protein NN cord-354029-mp5r82g4 538 16 from from IN cord-354029-mp5r82g4 538 17 an an DT cord-354029-mp5r82g4 538 18 inhibitor inhibitor NN cord-354029-mp5r82g4 538 19 to to IN cord-354029-mp5r82g4 538 20 an an DT cord-354029-mp5r82g4 538 21 activator activator NN cord-354029-mp5r82g4 538 22 of of IN cord-354029-mp5r82g4 538 23 fusion fusion NN cord-354029-mp5r82g4 538 24 Effect effect NN cord-354029-mp5r82g4 538 25 of of IN cord-354029-mp5r82g4 538 26 proteolytic proteolytic JJ cord-354029-mp5r82g4 538 27 processing processing NN cord-354029-mp5r82g4 538 28 at at IN cord-354029-mp5r82g4 538 29 two two CD cord-354029-mp5r82g4 538 30 distinct distinct JJ cord-354029-mp5r82g4 538 31 sites site NNS cord-354029-mp5r82g4 538 32 on on IN cord-354029-mp5r82g4 538 33 shape shape NN cord-354029-mp5r82g4 538 34 and and CC cord-354029-mp5r82g4 538 35 aggregation aggregation NN cord-354029-mp5r82g4 538 36 of of IN cord-354029-mp5r82g4 538 37 an an DT cord-354029-mp5r82g4 538 38 anchorless anchorless JJ cord-354029-mp5r82g4 538 39 fusion fusion NN cord-354029-mp5r82g4 538 40 protein protein NN cord-354029-mp5r82g4 538 41 of of IN cord-354029-mp5r82g4 538 42 human human JJ cord-354029-mp5r82g4 538 43 respiratory respiratory JJ cord-354029-mp5r82g4 538 44 syncytial syncytial JJ cord-354029-mp5r82g4 538 45 virus virus NN cord-354029-mp5r82g4 538 46 and and CC cord-354029-mp5r82g4 538 47 fate fate NN cord-354029-mp5r82g4 538 48 of of IN cord-354029-mp5r82g4 538 49 the the DT cord-354029-mp5r82g4 538 50 intervening intervene VBG cord-354029-mp5r82g4 538 51 segment segment NN cord-354029-mp5r82g4 538 52 Dilation dilation NN cord-354029-mp5r82g4 538 53 of of IN cord-354029-mp5r82g4 538 54 the the DT cord-354029-mp5r82g4 538 55 influenza influenza NN cord-354029-mp5r82g4 538 56 hemagglutinin hemagglutinin NNP cord-354029-mp5r82g4 538 57 fusion fusion NN cord-354029-mp5r82g4 538 58 pore pore NN cord-354029-mp5r82g4 538 59 revealed reveal VBN cord-354029-mp5r82g4 538 60 by by IN cord-354029-mp5r82g4 538 61 the the DT cord-354029-mp5r82g4 538 62 kinetics kinetic NNS cord-354029-mp5r82g4 538 63 of of IN cord-354029-mp5r82g4 538 64 individual individual JJ cord-354029-mp5r82g4 538 65 cellcell cellcell NN cord-354029-mp5r82g4 538 66 fusion fusion NN cord-354029-mp5r82g4 538 67 events event NNS cord-354029-mp5r82g4 538 68 Identification Identification NNP cord-354029-mp5r82g4 538 69 of of IN cord-354029-mp5r82g4 538 70 R r NN cord-354029-mp5r82g4 538 71 - - HYPH cord-354029-mp5r82g4 538 72 peptides peptide NNS cord-354029-mp5r82g4 538 73 in in IN cord-354029-mp5r82g4 538 74 envelope envelope NN cord-354029-mp5r82g4 538 75 proteins protein NNS cord-354029-mp5r82g4 538 76 of of IN cord-354029-mp5r82g4 538 77 C c NN cord-354029-mp5r82g4 538 78 - - HYPH cord-354029-mp5r82g4 538 79 type type NN cord-354029-mp5r82g4 538 80 retroviruses retrovirus NNS cord-354029-mp5r82g4 539 1 Inhibition inhibition NN cord-354029-mp5r82g4 539 2 of of IN cord-354029-mp5r82g4 539 3 the the DT cord-354029-mp5r82g4 539 4 fusion fusion NN cord-354029-mp5r82g4 539 5 - - HYPH cord-354029-mp5r82g4 539 6 inducing induce VBG cord-354029-mp5r82g4 539 7 conformational conformational JJ cord-354029-mp5r82g4 539 8 change change NN cord-354029-mp5r82g4 539 9 of of IN cord-354029-mp5r82g4 539 10 influenza influenza NN cord-354029-mp5r82g4 539 11 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 539 12 by by IN cord-354029-mp5r82g4 539 13 benzoquinones benzoquinone NNS cord-354029-mp5r82g4 539 14 and and CC cord-354029-mp5r82g4 539 15 hydroquinones hydroquinones NNP cord-354029-mp5r82g4 539 16 Completion Completion NNP cord-354029-mp5r82g4 539 17 of of IN cord-354029-mp5r82g4 539 18 trimeric trimeric NNP cord-354029-mp5r82g4 539 19 hairpin hairpin NN cord-354029-mp5r82g4 539 20 formation formation NN cord-354029-mp5r82g4 539 21 of of IN cord-354029-mp5r82g4 539 22 influenza influenza NN cord-354029-mp5r82g4 539 23 virus virus NN cord-354029-mp5r82g4 539 24 hemagglutinin hemagglutinin NNP cord-354029-mp5r82g4 539 25 promotes promote VBZ cord-354029-mp5r82g4 539 26 fusion fusion NN cord-354029-mp5r82g4 539 27 pore pore NN cord-354029-mp5r82g4 539 28 opening opening NN cord-354029-mp5r82g4 539 29 and and CC cord-354029-mp5r82g4 539 30 enlargement enlargement NN cord-354029-mp5r82g4 540 1 The the DT cord-354029-mp5r82g4 540 2 coronavirus coronavirus NN cord-354029-mp5r82g4 540 3 spike spike NN cord-354029-mp5r82g4 540 4 protein protein NN cord-354029-mp5r82g4 540 5 is be VBZ cord-354029-mp5r82g4 540 6 a a DT cord-354029-mp5r82g4 540 7 class class NN cord-354029-mp5r82g4 540 8 I -PRON- PRP cord-354029-mp5r82g4 540 9 virus virus NN cord-354029-mp5r82g4 540 10 fusion fusion NN cord-354029-mp5r82g4 540 11 protein protein NN cord-354029-mp5r82g4 540 12 : : : cord-354029-mp5r82g4 540 13 structural structural JJ cord-354029-mp5r82g4 540 14 and and CC cord-354029-mp5r82g4 540 15 functional functional JJ cord-354029-mp5r82g4 540 16 characterization characterization NN cord-354029-mp5r82g4 540 17 of of IN cord-354029-mp5r82g4 540 18 the the DT cord-354029-mp5r82g4 540 19 fusion fusion NN cord-354029-mp5r82g4 540 20 core core NN cord-354029-mp5r82g4 540 21 complex complex NN cord-354029-mp5r82g4 540 22 Membrane membrane NN cord-354029-mp5r82g4 540 23 fusion fusion NN cord-354029-mp5r82g4 540 24 tropism tropism NN cord-354029-mp5r82g4 540 25 and and CC cord-354029-mp5r82g4 540 26 heterotypic heterotypic JJ cord-354029-mp5r82g4 540 27 functional functional JJ cord-354029-mp5r82g4 540 28 activities activity NNS cord-354029-mp5r82g4 540 29 of of IN cord-354029-mp5r82g4 540 30 the the DT cord-354029-mp5r82g4 540 31 nipah nipah NNP cord-354029-mp5r82g4 540 32 virus virus NN cord-354029-mp5r82g4 540 33 and and CC cord-354029-mp5r82g4 540 34 hendra hendra NNP cord-354029-mp5r82g4 540 35 virus virus NN cord-354029-mp5r82g4 540 36 envelope envelope NN cord-354029-mp5r82g4 540 37 glycoproteins glycoprotein NNS cord-354029-mp5r82g4 540 38 Structure Structure NNP cord-354029-mp5r82g4 540 39 of of IN cord-354029-mp5r82g4 540 40 a a DT cord-354029-mp5r82g4 540 41 flavivirus flavivirus JJ cord-354029-mp5r82g4 540 42 envelope envelope NN cord-354029-mp5r82g4 540 43 glycoprotein glycoprotein NN cord-354029-mp5r82g4 540 44 in in IN cord-354029-mp5r82g4 540 45 its -PRON- PRP$ cord-354029-mp5r82g4 540 46 low low JJ cord-354029-mp5r82g4 540 47 - - HYPH cord-354029-mp5r82g4 540 48 pH ph NN cord-354029-mp5r82g4 540 49 - - HYPH cord-354029-mp5r82g4 540 50 induced induce VBN cord-354029-mp5r82g4 540 51 membrane membrane NN cord-354029-mp5r82g4 540 52 fusion fusion NN cord-354029-mp5r82g4 540 53 conformation conformation NN cord-354029-mp5r82g4 540 54 Membrane membrane NN cord-354029-mp5r82g4 540 55 fusion fusion NN cord-354029-mp5r82g4 540 56 of of IN cord-354029-mp5r82g4 540 57 Semliki Semliki NNP cord-354029-mp5r82g4 540 58 Forest Forest NNP cord-354029-mp5r82g4 540 59 virus virus NN cord-354029-mp5r82g4 540 60 in in IN cord-354029-mp5r82g4 540 61 a a DT cord-354029-mp5r82g4 540 62 model model NN cord-354029-mp5r82g4 540 63 system system NN cord-354029-mp5r82g4 540 64 : : : cord-354029-mp5r82g4 540 65 correlation correlation NN cord-354029-mp5r82g4 540 66 between between IN cord-354029-mp5r82g4 540 67 fusion fusion NN cord-354029-mp5r82g4 540 68 kinetics kinetic NNS cord-354029-mp5r82g4 540 69 and and CC cord-354029-mp5r82g4 540 70 structural structural JJ cord-354029-mp5r82g4 540 71 changes change NNS cord-354029-mp5r82g4 540 72 in in IN cord-354029-mp5r82g4 540 73 the the DT cord-354029-mp5r82g4 540 74 envelope envelope NN cord-354029-mp5r82g4 540 75 glycoprotein glycoprotein NN cord-354029-mp5r82g4 540 76 Structure structure NN cord-354029-mp5r82g4 540 77 and and CC cord-354029-mp5r82g4 540 78 function function NN cord-354029-mp5r82g4 540 79 of of IN cord-354029-mp5r82g4 540 80 sphingolipid sphingolipid NN cord-354029-mp5r82g4 540 81 - - HYPH cord-354029-mp5r82g4 540 82 and and CC cord-354029-mp5r82g4 540 83 cholesterol cholesterol NN cord-354029-mp5r82g4 540 84 - - HYPH cord-354029-mp5r82g4 540 85 rich rich JJ cord-354029-mp5r82g4 540 86 membrane membrane NN cord-354029-mp5r82g4 540 87 rafts raft NNS cord-354029-mp5r82g4 540 88 Structure Structure NNP cord-354029-mp5r82g4 540 89 of of IN cord-354029-mp5r82g4 540 90 influenza influenza NN cord-354029-mp5r82g4 540 91 haemagglutinin haemagglutinin NNP cord-354029-mp5r82g4 540 92 at at IN cord-354029-mp5r82g4 540 93 the the DT cord-354029-mp5r82g4 540 94 pH pH NNP cord-354029-mp5r82g4 540 95 of of IN cord-354029-mp5r82g4 540 96 membrane membrane NN cord-354029-mp5r82g4 540 97 fusion fusion NN cord-354029-mp5r82g4 540 98 Electron Electron NNP cord-354029-mp5r82g4 540 99 microscopy microscopy NN cord-354029-mp5r82g4 540 100 of of IN cord-354029-mp5r82g4 540 101 the the DT cord-354029-mp5r82g4 540 102 human human JJ cord-354029-mp5r82g4 540 103 respiratory respiratory JJ cord-354029-mp5r82g4 540 104 syncytial syncytial JJ cord-354029-mp5r82g4 540 105 virus virus NN cord-354029-mp5r82g4 540 106 fusion fusion NN cord-354029-mp5r82g4 540 107 protein protein NN cord-354029-mp5r82g4 540 108 and and CC cord-354029-mp5r82g4 540 109 complexes complex NNS cord-354029-mp5r82g4 540 110 that that IN cord-354029-mp5r82g4 540 111 it -PRON- PRP cord-354029-mp5r82g4 540 112 forms form VBZ cord-354029-mp5r82g4 540 113 with with IN cord-354029-mp5r82g4 540 114 monoclonal monoclonal JJ cord-354029-mp5r82g4 540 115 antibodies antibody NNS cord-354029-mp5r82g4 541 1 Influenza influenza NN cord-354029-mp5r82g4 541 2 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 541 3 is be VBZ cord-354029-mp5r82g4 541 4 spring spring NN cord-354029-mp5r82g4 541 5 - - HYPH cord-354029-mp5r82g4 541 6 loaded load VBN cord-354029-mp5r82g4 541 7 by by IN cord-354029-mp5r82g4 541 8 a a DT cord-354029-mp5r82g4 541 9 metastable metastable JJ cord-354029-mp5r82g4 541 10 native native JJ cord-354029-mp5r82g4 541 11 conformation conformation NN cord-354029-mp5r82g4 542 1 A a DT cord-354029-mp5r82g4 542 2 spring spring NN cord-354029-mp5r82g4 542 3 - - HYPH cord-354029-mp5r82g4 542 4 loaded load VBN cord-354029-mp5r82g4 542 5 mechanism mechanism NN cord-354029-mp5r82g4 542 6 for for IN cord-354029-mp5r82g4 542 7 the the DT cord-354029-mp5r82g4 542 8 conformational conformational JJ cord-354029-mp5r82g4 542 9 change change NN cord-354029-mp5r82g4 542 10 of of IN cord-354029-mp5r82g4 542 11 influenza influenza NN cord-354029-mp5r82g4 542 12 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 542 13 Measles measles NN cord-354029-mp5r82g4 542 14 viruses virus NNS cord-354029-mp5r82g4 542 15 with with IN cord-354029-mp5r82g4 542 16 altered altered JJ cord-354029-mp5r82g4 542 17 envelope envelope NN cord-354029-mp5r82g4 542 18 protein protein NN cord-354029-mp5r82g4 542 19 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 542 20 tails tail NNS cord-354029-mp5r82g4 542 21 gain gain VBP cord-354029-mp5r82g4 542 22 cell cell NN cord-354029-mp5r82g4 542 23 fusion fusion NN cord-354029-mp5r82g4 542 24 competence competence NN cord-354029-mp5r82g4 542 25 Core core NN cord-354029-mp5r82g4 542 26 structure structure NN cord-354029-mp5r82g4 542 27 of of IN cord-354029-mp5r82g4 542 28 gp41 gp41 NNP cord-354029-mp5r82g4 542 29 from from IN cord-354029-mp5r82g4 542 30 the the DT cord-354029-mp5r82g4 542 31 HIV HIV NNP cord-354029-mp5r82g4 542 32 envelope envelope NN cord-354029-mp5r82g4 542 33 glycoprotein glycoprotein NN cord-354029-mp5r82g4 542 34 HIV HIV NNP cord-354029-mp5r82g4 542 35 entry entry NN cord-354029-mp5r82g4 542 36 and and CC cord-354029-mp5r82g4 542 37 its -PRON- PRP$ cord-354029-mp5r82g4 542 38 inhibition inhibition NN cord-354029-mp5r82g4 542 39 Structure structure NN cord-354029-mp5r82g4 542 40 of of IN cord-354029-mp5r82g4 542 41 the the DT cord-354029-mp5r82g4 542 42 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 542 43 precursor precursor NN cord-354029-mp5r82g4 542 44 cleavage cleavage NN cord-354029-mp5r82g4 542 45 site site NN cord-354029-mp5r82g4 542 46 , , , cord-354029-mp5r82g4 542 47 a a DT cord-354029-mp5r82g4 542 48 determinant determinant NN cord-354029-mp5r82g4 542 49 of of IN cord-354029-mp5r82g4 542 50 influenza influenza NN cord-354029-mp5r82g4 542 51 pathogenicity pathogenicity NN cord-354029-mp5r82g4 542 52 and and CC cord-354029-mp5r82g4 542 53 the the DT cord-354029-mp5r82g4 542 54 origin origin NN cord-354029-mp5r82g4 542 55 of of IN cord-354029-mp5r82g4 542 56 the the DT cord-354029-mp5r82g4 542 57 labile labile JJ cord-354029-mp5r82g4 542 58 conformation conformation NN cord-354029-mp5r82g4 542 59 N N NNP cord-354029-mp5r82g4 542 60 - - : cord-354029-mp5r82g4 542 61 and and CC cord-354029-mp5r82g4 542 62 C c NN cord-354029-mp5r82g4 542 63 - - HYPH cord-354029-mp5r82g4 542 64 terminal terminal NN cord-354029-mp5r82g4 542 65 residues residue NNS cord-354029-mp5r82g4 542 66 combine combine VBP cord-354029-mp5r82g4 542 67 in in IN cord-354029-mp5r82g4 542 68 the the DT cord-354029-mp5r82g4 542 69 fusion fusion NN cord-354029-mp5r82g4 542 70 - - HYPH cord-354029-mp5r82g4 542 71 pH ph NN cord-354029-mp5r82g4 542 72 influenza influenza NN cord-354029-mp5r82g4 542 73 hemagglutinin hemagglutinin VBN cord-354029-mp5r82g4 542 74 HA(2 HA(2 NNP cord-354029-mp5r82g4 542 75 ) ) -RRB- cord-354029-mp5r82g4 542 76 subunit subunit NN cord-354029-mp5r82g4 542 77 to to TO cord-354029-mp5r82g4 542 78 form form VB cord-354029-mp5r82g4 542 79 an an DT cord-354029-mp5r82g4 542 80 N n CD cord-354029-mp5r82g4 542 81 cap cap NN cord-354029-mp5r82g4 542 82 that that WDT cord-354029-mp5r82g4 542 83 terminates terminate VBZ cord-354029-mp5r82g4 542 84 the the DT cord-354029-mp5r82g4 542 85 triple triple RB cord-354029-mp5r82g4 542 86 - - HYPH cord-354029-mp5r82g4 542 87 stranded stranded JJ cord-354029-mp5r82g4 542 88 coiled coiled JJ cord-354029-mp5r82g4 542 89 coil coil NN cord-354029-mp5r82g4 543 1 The the DT cord-354029-mp5r82g4 543 2 structure structure NN cord-354029-mp5r82g4 543 3 of of IN cord-354029-mp5r82g4 543 4 the the DT cord-354029-mp5r82g4 543 5 fusion fusion NN cord-354029-mp5r82g4 543 6 glycoprotein glycoprotein NN cord-354029-mp5r82g4 543 7 of of IN cord-354029-mp5r82g4 543 8 Newcastle Newcastle NNP cord-354029-mp5r82g4 543 9 disease disease NN cord-354029-mp5r82g4 543 10 virus virus NN cord-354029-mp5r82g4 543 11 suggests suggest VBZ cord-354029-mp5r82g4 543 12 a a DT cord-354029-mp5r82g4 543 13 novel novel JJ cord-354029-mp5r82g4 543 14 paradigm paradigm NN cord-354029-mp5r82g4 543 15 for for IN cord-354029-mp5r82g4 543 16 the the DT cord-354029-mp5r82g4 543 17 molecular molecular JJ cord-354029-mp5r82g4 543 18 mechanism mechanism NN cord-354029-mp5r82g4 543 19 of of IN cord-354029-mp5r82g4 543 20 membrane membrane NN cord-354029-mp5r82g4 543 21 fusion fusion NN cord-354029-mp5r82g4 543 22 Cellular cellular JJ cord-354029-mp5r82g4 543 23 membrane membrane NN cord-354029-mp5r82g4 543 24 - - HYPH cord-354029-mp5r82g4 543 25 binding bind VBG cord-354029-mp5r82g4 543 26 ability ability NN cord-354029-mp5r82g4 543 27 of of IN cord-354029-mp5r82g4 543 28 the the DT cord-354029-mp5r82g4 543 29 C c NN cord-354029-mp5r82g4 543 30 - - HYPH cord-354029-mp5r82g4 543 31 terminal terminal JJ cord-354029-mp5r82g4 543 32 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 543 33 domain domain NN cord-354029-mp5r82g4 543 34 of of IN cord-354029-mp5r82g4 543 35 human human JJ cord-354029-mp5r82g4 543 36 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 543 37 virus virus NN cord-354029-mp5r82g4 543 38 type type NN cord-354029-mp5r82g4 543 39 1 1 CD cord-354029-mp5r82g4 543 40 envelope envelope NN cord-354029-mp5r82g4 543 41 transmembrane transmembrane NN cord-354029-mp5r82g4 543 42 protein protein NN cord-354029-mp5r82g4 543 43 gp41 gp41 NNP cord-354029-mp5r82g4 543 44 pH ph NN cord-354029-mp5r82g4 543 45 - - HYPH cord-354029-mp5r82g4 543 46 dependent dependent JJ cord-354029-mp5r82g4 543 47 changes change NNS cord-354029-mp5r82g4 543 48 in in IN cord-354029-mp5r82g4 543 49 photoaffinity photoaffinity NN cord-354029-mp5r82g4 543 50 labeling labeling NN cord-354029-mp5r82g4 543 51 patterns pattern NNS cord-354029-mp5r82g4 543 52 of of IN cord-354029-mp5r82g4 543 53 the the DT cord-354029-mp5r82g4 543 54 H1 H1 NNP cord-354029-mp5r82g4 543 55 influenza influenza NN cord-354029-mp5r82g4 543 56 virus virus NN cord-354029-mp5r82g4 543 57 hemagglutinin hemagglutinin VBN cord-354029-mp5r82g4 543 58 by by IN cord-354029-mp5r82g4 543 59 using use VBG cord-354029-mp5r82g4 543 60 an an DT cord-354029-mp5r82g4 543 61 inhibitor inhibitor NN cord-354029-mp5r82g4 543 62 of of IN cord-354029-mp5r82g4 543 63 viral viral JJ cord-354029-mp5r82g4 543 64 fusion fusion NN cord-354029-mp5r82g4 544 1 The the DT cord-354029-mp5r82g4 544 2 transmembrane transmembrane NN cord-354029-mp5r82g4 544 3 domain domain NN cord-354029-mp5r82g4 544 4 in in IN cord-354029-mp5r82g4 544 5 viral viral JJ cord-354029-mp5r82g4 544 6 fusion fusion NN cord-354029-mp5r82g4 544 7 : : : cord-354029-mp5r82g4 544 8 essential essential JJ cord-354029-mp5r82g4 544 9 role role NN cord-354029-mp5r82g4 544 10 for for IN cord-354029-mp5r82g4 544 11 a a DT cord-354029-mp5r82g4 544 12 conserved conserve VBN cord-354029-mp5r82g4 544 13 glycine glycine NN cord-354029-mp5r82g4 544 14 residue residue NN cord-354029-mp5r82g4 544 15 in in IN cord-354029-mp5r82g4 544 16 vesicular vesicular JJ cord-354029-mp5r82g4 544 17 stomatitis stomatitis NN cord-354029-mp5r82g4 544 18 virus virus NN cord-354029-mp5r82g4 544 19 G g NN cord-354029-mp5r82g4 544 20 protein protein NN cord-354029-mp5r82g4 545 1 The the DT cord-354029-mp5r82g4 545 2 structural structural JJ cord-354029-mp5r82g4 545 3 biology biology NN cord-354029-mp5r82g4 545 4 of of IN cord-354029-mp5r82g4 545 5 type type NN cord-354029-mp5r82g4 545 6 I -PRON- PRP cord-354029-mp5r82g4 545 7 viral viral JJ cord-354029-mp5r82g4 545 8 membrane membrane NN cord-354029-mp5r82g4 545 9 fusion fusion NN cord-354029-mp5r82g4 545 10 Membrane membrane NN cord-354029-mp5r82g4 545 11 fusion fusion NN cord-354029-mp5r82g4 545 12 activity activity NN cord-354029-mp5r82g4 545 13 of of IN cord-354029-mp5r82g4 545 14 tick tick NN cord-354029-mp5r82g4 545 15 - - HYPH cord-354029-mp5r82g4 545 16 borne bear VBN cord-354029-mp5r82g4 545 17 encephalitis encephalitis JJ cord-354029-mp5r82g4 545 18 virus virus NN cord-354029-mp5r82g4 545 19 and and CC cord-354029-mp5r82g4 545 20 recombinant recombinant JJ cord-354029-mp5r82g4 545 21 subviral subviral JJ cord-354029-mp5r82g4 545 22 particles particle NNS cord-354029-mp5r82g4 545 23 in in IN cord-354029-mp5r82g4 545 24 a a DT cord-354029-mp5r82g4 545 25 liposomal liposomal JJ cord-354029-mp5r82g4 545 26 model model NN cord-354029-mp5r82g4 545 27 system system NN cord-354029-mp5r82g4 545 28 Receptor receptor NN cord-354029-mp5r82g4 545 29 - - HYPH cord-354029-mp5r82g4 545 30 triggered trigger VBN cord-354029-mp5r82g4 545 31 membrane membrane NN cord-354029-mp5r82g4 545 32 association association NN cord-354029-mp5r82g4 545 33 of of IN cord-354029-mp5r82g4 545 34 a a DT cord-354029-mp5r82g4 545 35 model model NN cord-354029-mp5r82g4 545 36 retroviral retroviral NN cord-354029-mp5r82g4 545 37 glycoprotein glycoprotein NN cord-354029-mp5r82g4 545 38 Membrane membrane NN cord-354029-mp5r82g4 545 39 fusion fusion NN cord-354029-mp5r82g4 545 40 mediated mediate VBN cord-354029-mp5r82g4 545 41 by by IN cord-354029-mp5r82g4 545 42 the the DT cord-354029-mp5r82g4 545 43 influenza influenza NN cord-354029-mp5r82g4 545 44 virus virus NN cord-354029-mp5r82g4 545 45 hemagglutinin hemagglutinin NNP cord-354029-mp5r82g4 545 46 requires require VBZ cord-354029-mp5r82g4 545 47 the the DT cord-354029-mp5r82g4 545 48 concerted concerted JJ cord-354029-mp5r82g4 545 49 action action NN cord-354029-mp5r82g4 545 50 of of IN cord-354029-mp5r82g4 545 51 at at RB cord-354029-mp5r82g4 545 52 least least RBS cord-354029-mp5r82g4 545 53 three three CD cord-354029-mp5r82g4 545 54 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 545 55 trimers trimers NNP cord-354029-mp5r82g4 545 56 Structure Structure NNP cord-354029-mp5r82g4 545 57 - - HYPH cord-354029-mp5r82g4 545 58 based base VBN cord-354029-mp5r82g4 545 59 identification identification NN cord-354029-mp5r82g4 545 60 of of IN cord-354029-mp5r82g4 545 61 small small JJ cord-354029-mp5r82g4 545 62 molecule molecule NN cord-354029-mp5r82g4 545 63 antiviral antiviral JJ cord-354029-mp5r82g4 545 64 compounds compound NNS cord-354029-mp5r82g4 545 65 targeted target VBN cord-354029-mp5r82g4 545 66 to to IN cord-354029-mp5r82g4 545 67 the the DT cord-354029-mp5r82g4 545 68 gp41 gp41 NNP cord-354029-mp5r82g4 545 69 core core NN cord-354029-mp5r82g4 545 70 structure structure NN cord-354029-mp5r82g4 545 71 of of IN cord-354029-mp5r82g4 545 72 the the DT cord-354029-mp5r82g4 545 73 human human JJ cord-354029-mp5r82g4 545 74 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 545 75 virus virus NN cord-354029-mp5r82g4 545 76 type type NN cord-354029-mp5r82g4 545 77 1 1 CD cord-354029-mp5r82g4 546 1 The the DT cord-354029-mp5r82g4 546 2 central central JJ cord-354029-mp5r82g4 546 3 proline proline NN cord-354029-mp5r82g4 546 4 of of IN cord-354029-mp5r82g4 546 5 an an DT cord-354029-mp5r82g4 546 6 internal internal JJ cord-354029-mp5r82g4 546 7 viral viral JJ cord-354029-mp5r82g4 546 8 fusion fusion NN cord-354029-mp5r82g4 546 9 peptide peptide NN cord-354029-mp5r82g4 546 10 serves serve VBZ cord-354029-mp5r82g4 546 11 two two CD cord-354029-mp5r82g4 546 12 important important JJ cord-354029-mp5r82g4 546 13 roles role NNS cord-354029-mp5r82g4 546 14 Critical critical JJ cord-354029-mp5r82g4 546 15 role role NN cord-354029-mp5r82g4 546 16 for for IN cord-354029-mp5r82g4 546 17 the the DT cord-354029-mp5r82g4 546 18 cysteines cysteine NNS cord-354029-mp5r82g4 546 19 flanking flank VBG cord-354029-mp5r82g4 546 20 the the DT cord-354029-mp5r82g4 546 21 internal internal JJ cord-354029-mp5r82g4 546 22 fusion fusion NN cord-354029-mp5r82g4 546 23 peptide peptide NN cord-354029-mp5r82g4 546 24 of of IN cord-354029-mp5r82g4 546 25 avian avian JJ cord-354029-mp5r82g4 546 26 sarcoma sarcoma NN cord-354029-mp5r82g4 546 27 / / SYM cord-354029-mp5r82g4 546 28 leukosis leukosis NN cord-354029-mp5r82g4 546 29 virus virus NN cord-354029-mp5r82g4 546 30 envelope envelope NN cord-354029-mp5r82g4 546 31 glycoprotein glycoprotein NN cord-354029-mp5r82g4 546 32 Mutations Mutations NNPS cord-354029-mp5r82g4 546 33 in in IN cord-354029-mp5r82g4 546 34 the the DT cord-354029-mp5r82g4 546 35 Newcastle Newcastle NNP cord-354029-mp5r82g4 546 36 disease disease NN cord-354029-mp5r82g4 546 37 virus virus NN cord-354029-mp5r82g4 546 38 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 546 39 - - : cord-354029-mp5r82g4 546 40 neuraminidase neuraminidase NN cord-354029-mp5r82g4 546 41 protein protein NN cord-354029-mp5r82g4 546 42 that that WDT cord-354029-mp5r82g4 546 43 interfere interfere VBP cord-354029-mp5r82g4 546 44 with with IN cord-354029-mp5r82g4 546 45 its -PRON- PRP$ cord-354029-mp5r82g4 546 46 ability ability NN cord-354029-mp5r82g4 546 47 to to TO cord-354029-mp5r82g4 546 48 interact interact VB cord-354029-mp5r82g4 546 49 with with IN cord-354029-mp5r82g4 546 50 the the DT cord-354029-mp5r82g4 546 51 homologous homologous JJ cord-354029-mp5r82g4 546 52 F F NNP cord-354029-mp5r82g4 546 53 protein protein NN cord-354029-mp5r82g4 546 54 in in IN cord-354029-mp5r82g4 546 55 the the DT cord-354029-mp5r82g4 546 56 promotion promotion NN cord-354029-mp5r82g4 546 57 of of IN cord-354029-mp5r82g4 546 58 fusion fusion NN cord-354029-mp5r82g4 546 59 try try VBP cord-354029-mp5r82g4 546 60 inhibitors inhibitor NNS cord-354029-mp5r82g4 546 61 from from IN cord-354029-mp5r82g4 546 62 biased biased JJ cord-354029-mp5r82g4 546 63 combinatorial combinatorial JJ cord-354029-mp5r82g4 546 64 libraries library NNS cord-354029-mp5r82g4 546 65 of of IN cord-354029-mp5r82g4 546 66 non non JJ cord-354029-mp5r82g4 546 67 - - JJ cord-354029-mp5r82g4 546 68 natural natural JJ cord-354029-mp5r82g4 546 69 binding binding NN cord-354029-mp5r82g4 546 70 elements element NNS cord-354029-mp5r82g4 546 71 Acylation Acylation NNP cord-354029-mp5r82g4 546 72 of of IN cord-354029-mp5r82g4 546 73 the the DT cord-354029-mp5r82g4 546 74 influenza influenza NN cord-354029-mp5r82g4 546 75 hemagglutinin hemagglutinin NNP cord-354029-mp5r82g4 546 76 modulates modulate VBZ cord-354029-mp5r82g4 546 77 fusion fusion NN cord-354029-mp5r82g4 546 78 activity activity NN cord-354029-mp5r82g4 547 1 Vesicular vesicular JJ cord-354029-mp5r82g4 547 2 stomatitis stomatitis NN cord-354029-mp5r82g4 547 3 virus virus NN cord-354029-mp5r82g4 547 4 glycoprotein glycoprotein NN cord-354029-mp5r82g4 547 5 mutations mutation NNS cord-354029-mp5r82g4 547 6 that that WDT cord-354029-mp5r82g4 547 7 affect affect VBP cord-354029-mp5r82g4 547 8 membrane membrane NN cord-354029-mp5r82g4 547 9 fusion fusion NN cord-354029-mp5r82g4 547 10 activity activity NN cord-354029-mp5r82g4 547 11 and and CC cord-354029-mp5r82g4 547 12 abolish abolish VB cord-354029-mp5r82g4 547 13 virus virus NN cord-354029-mp5r82g4 547 14 infectivity infectivity NN cord-354029-mp5r82g4 547 15 A a DT cord-354029-mp5r82g4 547 16 mutation mutation NN cord-354029-mp5r82g4 547 17 in in IN cord-354029-mp5r82g4 547 18 the the DT cord-354029-mp5r82g4 547 19 human human JJ cord-354029-mp5r82g4 547 20 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 547 21 virus virus NN cord-354029-mp5r82g4 547 22 type type NN cord-354029-mp5r82g4 547 23 1 1 CD cord-354029-mp5r82g4 547 24 transmembrane transmembrane NN cord-354029-mp5r82g4 547 25 glycoprotein glycoprotein NN cord-354029-mp5r82g4 547 26 gp41 gp41 NN cord-354029-mp5r82g4 547 27 dominantly dominantly RB cord-354029-mp5r82g4 547 28 interferes interfere VBZ cord-354029-mp5r82g4 547 29 with with IN cord-354029-mp5r82g4 547 30 fusion fusion NN cord-354029-mp5r82g4 547 31 and and CC cord-354029-mp5r82g4 547 32 infectivity infectivity NN cord-354029-mp5r82g4 547 33 Domains domain NNS cord-354029-mp5r82g4 547 34 of of IN cord-354029-mp5r82g4 547 35 the the DT cord-354029-mp5r82g4 547 36 human human JJ cord-354029-mp5r82g4 547 37 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 547 38 virus virus NN cord-354029-mp5r82g4 547 39 type type NN cord-354029-mp5r82g4 547 40 1 1 CD cord-354029-mp5r82g4 547 41 matrix matrix NN cord-354029-mp5r82g4 547 42 and and CC cord-354029-mp5r82g4 547 43 gp41 gp41 NN cord-354029-mp5r82g4 547 44 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 547 45 tail tail NN cord-354029-mp5r82g4 547 46 required require VBN cord-354029-mp5r82g4 547 47 for for IN cord-354029-mp5r82g4 547 48 envelope envelope NN cord-354029-mp5r82g4 547 49 incorporation incorporation NN cord-354029-mp5r82g4 547 50 into into IN cord-354029-mp5r82g4 547 51 virions virion NNS cord-354029-mp5r82g4 547 52 Temperature temperature NN cord-354029-mp5r82g4 547 53 dependence dependence NN cord-354029-mp5r82g4 547 54 of of IN cord-354029-mp5r82g4 547 55 cell cell NN cord-354029-mp5r82g4 547 56 - - HYPH cord-354029-mp5r82g4 547 57 cell cell NN cord-354029-mp5r82g4 547 58 fusion fusion NN cord-354029-mp5r82g4 547 59 induced induce VBN cord-354029-mp5r82g4 547 60 by by IN cord-354029-mp5r82g4 547 61 the the DT cord-354029-mp5r82g4 547 62 envelope envelope NN cord-354029-mp5r82g4 547 63 glycoprotein glycoprotein NN cord-354029-mp5r82g4 547 64 of of IN cord-354029-mp5r82g4 547 65 human human JJ cord-354029-mp5r82g4 547 66 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 547 67 virus virus NN cord-354029-mp5r82g4 547 68 type type NN cord-354029-mp5r82g4 547 69 1 1 CD cord-354029-mp5r82g4 547 70 A a DT cord-354029-mp5r82g4 547 71 molecular molecular JJ cord-354029-mp5r82g4 547 72 model model NN cord-354029-mp5r82g4 547 73 for for IN cord-354029-mp5r82g4 547 74 membrane membrane NN cord-354029-mp5r82g4 547 75 fusion fusion NN cord-354029-mp5r82g4 547 76 based base VBN cord-354029-mp5r82g4 547 77 on on IN cord-354029-mp5r82g4 547 78 solution solution NN cord-354029-mp5r82g4 547 79 studies study NNS cord-354029-mp5r82g4 547 80 of of IN cord-354029-mp5r82g4 547 81 an an DT cord-354029-mp5r82g4 547 82 amphiphilic amphiphilic JJ cord-354029-mp5r82g4 547 83 peptide peptide NN cord-354029-mp5r82g4 547 84 from from IN cord-354029-mp5r82g4 547 85 HIV HIV NNP cord-354029-mp5r82g4 547 86 gp41 gp41 NNP cord-354029-mp5r82g4 547 87 Capture capture NN cord-354029-mp5r82g4 547 88 of of IN cord-354029-mp5r82g4 547 89 an an DT cord-354029-mp5r82g4 547 90 early early JJ cord-354029-mp5r82g4 547 91 fusion fusion NN cord-354029-mp5r82g4 547 92 - - HYPH cord-354029-mp5r82g4 547 93 active active JJ cord-354029-mp5r82g4 547 94 conformation conformation NN cord-354029-mp5r82g4 547 95 of of IN cord-354029-mp5r82g4 547 96 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 547 97 gp41 gp41 NNP cord-354029-mp5r82g4 547 98 Inhibitors Inhibitors NNP cord-354029-mp5r82g4 547 99 of of IN cord-354029-mp5r82g4 547 100 protein protein NN cord-354029-mp5r82g4 547 101 - - HYPH cord-354029-mp5r82g4 547 102 disulfide disulfide NN cord-354029-mp5r82g4 547 103 isomerase isomerase NN cord-354029-mp5r82g4 547 104 prevent prevent VBP cord-354029-mp5r82g4 547 105 cleavage cleavage NN cord-354029-mp5r82g4 547 106 of of IN cord-354029-mp5r82g4 547 107 disulfide disulfide JJ cord-354029-mp5r82g4 547 108 bonds bond NNS cord-354029-mp5r82g4 547 109 in in IN cord-354029-mp5r82g4 547 110 receptor receptor NN cord-354029-mp5r82g4 547 111 - - HYPH cord-354029-mp5r82g4 547 112 bound bind VBN cord-354029-mp5r82g4 547 113 glycoprotein glycoprotein NN cord-354029-mp5r82g4 547 114 120 120 CD cord-354029-mp5r82g4 547 115 and and CC cord-354029-mp5r82g4 547 116 prevent prevent VB cord-354029-mp5r82g4 547 117 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 547 118 entry entry NN cord-354029-mp5r82g4 547 119 Mutations Mutations NNPS cord-354029-mp5r82g4 547 120 in in IN cord-354029-mp5r82g4 547 121 the the DT cord-354029-mp5r82g4 547 122 glycoprotein glycoprotein NN cord-354029-mp5r82g4 547 123 of of IN cord-354029-mp5r82g4 547 124 viral viral JJ cord-354029-mp5r82g4 547 125 haemorrhagic haemorrhagic JJ cord-354029-mp5r82g4 547 126 septicaemia septicaemia NN cord-354029-mp5r82g4 547 127 virus virus NN cord-354029-mp5r82g4 547 128 that that WDT cord-354029-mp5r82g4 547 129 affect affect VBP cord-354029-mp5r82g4 547 130 virulence virulence NN cord-354029-mp5r82g4 547 131 for for IN cord-354029-mp5r82g4 547 132 fish fish NN cord-354029-mp5r82g4 547 133 and and CC cord-354029-mp5r82g4 547 134 the the DT cord-354029-mp5r82g4 547 135 pH pH NNP cord-354029-mp5r82g4 547 136 threshold threshold NN cord-354029-mp5r82g4 547 137 for for IN cord-354029-mp5r82g4 547 138 membrane membrane NN cord-354029-mp5r82g4 547 139 fusion fusion NN cord-354029-mp5r82g4 547 140 Rabies Rabies NNP cord-354029-mp5r82g4 547 141 virus virus NN cord-354029-mp5r82g4 547 142 - - HYPH cord-354029-mp5r82g4 547 143 induced induce VBN cord-354029-mp5r82g4 547 144 membrane membrane NN cord-354029-mp5r82g4 547 145 fusion fusion NN cord-354029-mp5r82g4 547 146 Interaction Interaction NNP cord-354029-mp5r82g4 547 147 of of IN cord-354029-mp5r82g4 547 148 peptide peptide NN cord-354029-mp5r82g4 547 149 fragment fragment NN cord-354029-mp5r82g4 547 150 828 828 CD cord-354029-mp5r82g4 547 151 - - SYM cord-354029-mp5r82g4 547 152 848 848 CD cord-354029-mp5r82g4 547 153 of of IN cord-354029-mp5r82g4 547 154 the the DT cord-354029-mp5r82g4 547 155 envelope envelope NN cord-354029-mp5r82g4 547 156 glycoprotein glycoprotein NN cord-354029-mp5r82g4 547 157 of of IN cord-354029-mp5r82g4 547 158 human human JJ cord-354029-mp5r82g4 547 159 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 547 160 virus virus NN cord-354029-mp5r82g4 547 161 type type NN cord-354029-mp5r82g4 547 162 I -PRON- PRP cord-354029-mp5r82g4 547 163 with with IN cord-354029-mp5r82g4 547 164 lipid lipid NN cord-354029-mp5r82g4 547 165 bilayers bilayer NNS cord-354029-mp5r82g4 547 166 Studies study NNS cord-354029-mp5r82g4 547 167 on on IN cord-354029-mp5r82g4 547 168 the the DT cord-354029-mp5r82g4 547 169 mechanism mechanism NN cord-354029-mp5r82g4 547 170 of of IN cord-354029-mp5r82g4 547 171 membrane membrane NN cord-354029-mp5r82g4 547 172 fusion fusion NN cord-354029-mp5r82g4 547 173 : : : cord-354029-mp5r82g4 547 174 site site NN cord-354029-mp5r82g4 547 175 - - HYPH cord-354029-mp5r82g4 547 176 specific specific JJ cord-354029-mp5r82g4 547 177 mutagenesis mutagenesis NN cord-354029-mp5r82g4 547 178 of of IN cord-354029-mp5r82g4 547 179 the the DT cord-354029-mp5r82g4 547 180 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 547 181 of of IN cord-354029-mp5r82g4 547 182 influenza influenza NN cord-354029-mp5r82g4 547 183 virus virus NN cord-354029-mp5r82g4 547 184 Conformational Conformational NNP cord-354029-mp5r82g4 547 185 change change NN cord-354029-mp5r82g4 547 186 and and CC cord-354029-mp5r82g4 547 187 protein protein NN cord-354029-mp5r82g4 547 188 - - HYPH cord-354029-mp5r82g4 547 189 protein protein NN cord-354029-mp5r82g4 547 190 interactions interaction NNS cord-354029-mp5r82g4 547 191 of of IN cord-354029-mp5r82g4 547 192 the the DT cord-354029-mp5r82g4 547 193 fusion fusion NN cord-354029-mp5r82g4 547 194 protein protein NN cord-354029-mp5r82g4 547 195 of of IN cord-354029-mp5r82g4 547 196 Semliki Semliki NNP cord-354029-mp5r82g4 547 197 Forest Forest NNP cord-354029-mp5r82g4 547 198 virus virus NN cord-354029-mp5r82g4 547 199 Fusion Fusion NNP cord-354029-mp5r82g4 547 200 of of IN cord-354029-mp5r82g4 547 201 Rous rous JJ cord-354029-mp5r82g4 547 202 sarcoma sarcoma NN cord-354029-mp5r82g4 547 203 virus virus NN cord-354029-mp5r82g4 547 204 with with IN cord-354029-mp5r82g4 547 205 host host NN cord-354029-mp5r82g4 547 206 cells cell NNS cord-354029-mp5r82g4 547 207 does do VBZ cord-354029-mp5r82g4 547 208 not not RB cord-354029-mp5r82g4 547 209 require require VB cord-354029-mp5r82g4 547 210 exposure exposure NN cord-354029-mp5r82g4 547 211 to to IN cord-354029-mp5r82g4 547 212 low low JJ cord-354029-mp5r82g4 547 213 pH ph NN cord-354029-mp5r82g4 547 214 Introduction introduction NN cord-354029-mp5r82g4 547 215 of of IN cord-354029-mp5r82g4 547 216 intersubunit intersubunit NNP cord-354029-mp5r82g4 547 217 disulfide disulfide NN cord-354029-mp5r82g4 547 218 bonds bond NNS cord-354029-mp5r82g4 547 219 in in IN cord-354029-mp5r82g4 547 220 the the DT cord-354029-mp5r82g4 547 221 membrane membrane NN cord-354029-mp5r82g4 547 222 - - HYPH cord-354029-mp5r82g4 547 223 distal distal JJ cord-354029-mp5r82g4 547 224 region region NN cord-354029-mp5r82g4 547 225 of of IN cord-354029-mp5r82g4 547 226 the the DT cord-354029-mp5r82g4 547 227 influenza influenza NN cord-354029-mp5r82g4 547 228 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 547 229 abolishes abolish VBZ cord-354029-mp5r82g4 547 230 membrane membrane NN cord-354029-mp5r82g4 547 231 fusion fusion NN cord-354029-mp5r82g4 547 232 activity activity NN cord-354029-mp5r82g4 547 233 Dissection dissection NN cord-354029-mp5r82g4 547 234 of of IN cord-354029-mp5r82g4 547 235 human human JJ cord-354029-mp5r82g4 547 236 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 547 237 virus virus NN cord-354029-mp5r82g4 547 238 type type NN cord-354029-mp5r82g4 547 239 1 1 CD cord-354029-mp5r82g4 547 240 entry entry NN cord-354029-mp5r82g4 547 241 with with IN cord-354029-mp5r82g4 547 242 neutralizing neutralize VBG cord-354029-mp5r82g4 547 243 antibodies antibody NNS cord-354029-mp5r82g4 547 244 to to IN cord-354029-mp5r82g4 547 245 gp41 gp41 NN cord-354029-mp5r82g4 547 246 fusion fusion NN cord-354029-mp5r82g4 547 247 intermediates intermediate NNS cord-354029-mp5r82g4 548 1 A a DT cord-354029-mp5r82g4 548 2 new new JJ cord-354029-mp5r82g4 548 3 mechanism mechanism NN cord-354029-mp5r82g4 548 4 for for IN cord-354029-mp5r82g4 548 5 the the DT cord-354029-mp5r82g4 548 6 neutralization neutralization NN cord-354029-mp5r82g4 548 7 of of IN cord-354029-mp5r82g4 548 8 enveloped envelop VBN cord-354029-mp5r82g4 548 9 viruses virus NNS cord-354029-mp5r82g4 548 10 by by IN cord-354029-mp5r82g4 548 11 antiviral antiviral JJ cord-354029-mp5r82g4 548 12 antibody antibody NN cord-354029-mp5r82g4 548 13 Cleavage cleavage NN cord-354029-mp5r82g4 548 14 of of IN cord-354029-mp5r82g4 548 15 the the DT cord-354029-mp5r82g4 548 16 human human JJ cord-354029-mp5r82g4 548 17 respiratory respiratory JJ cord-354029-mp5r82g4 548 18 syncytial syncytial JJ cord-354029-mp5r82g4 548 19 virus virus NN cord-354029-mp5r82g4 548 20 fusion fusion NN cord-354029-mp5r82g4 548 21 protein protein NN cord-354029-mp5r82g4 548 22 at at IN cord-354029-mp5r82g4 548 23 two two CD cord-354029-mp5r82g4 548 24 distinct distinct JJ cord-354029-mp5r82g4 548 25 sites site NNS cord-354029-mp5r82g4 548 26 is be VBZ cord-354029-mp5r82g4 548 27 required require VBN cord-354029-mp5r82g4 548 28 for for IN cord-354029-mp5r82g4 548 29 activation activation NN cord-354029-mp5r82g4 548 30 of of IN cord-354029-mp5r82g4 548 31 membrane membrane NN cord-354029-mp5r82g4 548 32 fusion fusion NN cord-354029-mp5r82g4 548 33 New new JJ cord-354029-mp5r82g4 548 34 insights insight NNS cord-354029-mp5r82g4 548 35 into into IN cord-354029-mp5r82g4 548 36 the the DT cord-354029-mp5r82g4 548 37 spring spring NN cord-354029-mp5r82g4 548 38 - - HYPH cord-354029-mp5r82g4 548 39 loaded load VBN cord-354029-mp5r82g4 548 40 conformational conformational JJ cord-354029-mp5r82g4 548 41 change change NN cord-354029-mp5r82g4 548 42 of of IN cord-354029-mp5r82g4 548 43 influenza influenza NN cord-354029-mp5r82g4 548 44 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 548 45 Role role NN cord-354029-mp5r82g4 548 46 of of IN cord-354029-mp5r82g4 548 47 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 548 48 surface surface NN cord-354029-mp5r82g4 548 49 density density NN cord-354029-mp5r82g4 548 50 in in IN cord-354029-mp5r82g4 548 51 the the DT cord-354029-mp5r82g4 548 52 initial initial JJ cord-354029-mp5r82g4 548 53 stages stage NNS cord-354029-mp5r82g4 548 54 of of IN cord-354029-mp5r82g4 548 55 influenza influenza NN cord-354029-mp5r82g4 548 56 virus virus NN cord-354029-mp5r82g4 548 57 fusion fusion NN cord-354029-mp5r82g4 548 58 : : : cord-354029-mp5r82g4 548 59 lack lack NN cord-354029-mp5r82g4 548 60 of of IN cord-354029-mp5r82g4 548 61 evidence evidence NN cord-354029-mp5r82g4 548 62 for for IN cord-354029-mp5r82g4 548 63 cooperativity cooperativity NN cord-354029-mp5r82g4 549 1 The the DT cord-354029-mp5r82g4 549 2 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 549 3 tail tail NN cord-354029-mp5r82g4 549 4 of of IN cord-354029-mp5r82g4 549 5 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 549 6 gp160 gp160 NNP cord-354029-mp5r82g4 549 7 contains contain VBZ cord-354029-mp5r82g4 549 8 regions region NNS cord-354029-mp5r82g4 549 9 that that WDT cord-354029-mp5r82g4 549 10 associate associate VBP cord-354029-mp5r82g4 549 11 with with IN cord-354029-mp5r82g4 549 12 cellular cellular JJ cord-354029-mp5r82g4 549 13 membranes membrane NNS cord-354029-mp5r82g4 549 14 Membrane Membrane NNP cord-354029-mp5r82g4 549 15 structure structure NN cord-354029-mp5r82g4 549 16 and and CC cord-354029-mp5r82g4 549 17 fusion fusion NN cord-354029-mp5r82g4 549 18 - - HYPH cord-354029-mp5r82g4 549 19 triggering trigger VBG cord-354029-mp5r82g4 549 20 conformational conformational JJ cord-354029-mp5r82g4 549 21 change change NN cord-354029-mp5r82g4 549 22 of of IN cord-354029-mp5r82g4 549 23 the the DT cord-354029-mp5r82g4 549 24 fusion fusion NN cord-354029-mp5r82g4 549 25 domain domain NN cord-354029-mp5r82g4 549 26 from from IN cord-354029-mp5r82g4 549 27 influenza influenza NN cord-354029-mp5r82g4 549 28 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 549 29 Peptides peptide NNS cord-354029-mp5r82g4 549 30 trap trap VBP cord-354029-mp5r82g4 549 31 the the DT cord-354029-mp5r82g4 549 32 human human JJ cord-354029-mp5r82g4 549 33 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 549 34 virus virus NN cord-354029-mp5r82g4 549 35 type type NN cord-354029-mp5r82g4 549 36 1 1 CD cord-354029-mp5r82g4 549 37 envelope envelope NN cord-354029-mp5r82g4 549 38 glycoprotein glycoprotein NN cord-354029-mp5r82g4 549 39 fusion fusion NN cord-354029-mp5r82g4 549 40 intermediate intermediate JJ cord-354029-mp5r82g4 549 41 at at IN cord-354029-mp5r82g4 549 42 two two CD cord-354029-mp5r82g4 549 43 sites site NNS cord-354029-mp5r82g4 550 1 The the DT cord-354029-mp5r82g4 550 2 machinery machinery NN cord-354029-mp5r82g4 550 3 for for IN cord-354029-mp5r82g4 550 4 flavivirus flavivirus NNP cord-354029-mp5r82g4 550 5 fusion fusion NN cord-354029-mp5r82g4 550 6 with with IN cord-354029-mp5r82g4 550 7 host host NN cord-354029-mp5r82g4 550 8 cell cell NN cord-354029-mp5r82g4 550 9 membranes membrane NNS cord-354029-mp5r82g4 550 10 Alphavirus Alphavirus NNP cord-354029-mp5r82g4 550 11 and and CC cord-354029-mp5r82g4 550 12 flavivirus flavivirus JJ cord-354029-mp5r82g4 550 13 glycoproteins glycoprotein NNS cord-354029-mp5r82g4 550 14 : : : cord-354029-mp5r82g4 550 15 structures structure NNS cord-354029-mp5r82g4 550 16 and and CC cord-354029-mp5r82g4 550 17 functions function NNS cord-354029-mp5r82g4 550 18 Virus virus NN cord-354029-mp5r82g4 550 19 - - HYPH cord-354029-mp5r82g4 550 20 cell cell NN cord-354029-mp5r82g4 550 21 and and CC cord-354029-mp5r82g4 550 22 cellcell cellcell NNP cord-354029-mp5r82g4 550 23 fusion fusion NNP cord-354029-mp5r82g4 550 24 Activation Activation NNP cord-354029-mp5r82g4 550 25 of of IN cord-354029-mp5r82g4 550 26 a a DT cord-354029-mp5r82g4 550 27 retroviral retroviral JJ cord-354029-mp5r82g4 550 28 membrane membrane NN cord-354029-mp5r82g4 550 29 fusion fusion NN cord-354029-mp5r82g4 550 30 protein protein NN cord-354029-mp5r82g4 550 31 : : : cord-354029-mp5r82g4 550 32 soluble soluble JJ cord-354029-mp5r82g4 550 33 receptor receptor NN cord-354029-mp5r82g4 550 34 - - HYPH cord-354029-mp5r82g4 550 35 induced induce VBN cord-354029-mp5r82g4 550 36 liposome liposome NN cord-354029-mp5r82g4 550 37 binding bind VBG cord-354029-mp5r82g4 550 38 of of IN cord-354029-mp5r82g4 550 39 the the DT cord-354029-mp5r82g4 550 40 ALSV ALSV NNP cord-354029-mp5r82g4 550 41 envelope envelope NN cord-354029-mp5r82g4 550 42 glycoprotein glycoprotein NN cord-354029-mp5r82g4 550 43 Mutational mutational JJ cord-354029-mp5r82g4 550 44 analysis analysis NN cord-354029-mp5r82g4 550 45 of of IN cord-354029-mp5r82g4 550 46 the the DT cord-354029-mp5r82g4 550 47 candidate candidate NN cord-354029-mp5r82g4 550 48 internal internal JJ cord-354029-mp5r82g4 550 49 fusion fusion NN cord-354029-mp5r82g4 550 50 peptide peptide NN cord-354029-mp5r82g4 550 51 of of IN cord-354029-mp5r82g4 550 52 the the DT cord-354029-mp5r82g4 550 53 avian avian JJ cord-354029-mp5r82g4 550 54 leukosis leukosis NNP cord-354029-mp5r82g4 550 55 and and CC cord-354029-mp5r82g4 550 56 sarcoma sarcoma NNP cord-354029-mp5r82g4 550 57 virus virus NN cord-354029-mp5r82g4 550 58 subgroup subgroup NN cord-354029-mp5r82g4 550 59 A a DT cord-354029-mp5r82g4 550 60 envelope envelope NN cord-354029-mp5r82g4 550 61 glycoprotein glycoprotein NN cord-354029-mp5r82g4 550 62 Structure structure NN cord-354029-mp5r82g4 550 63 - - HYPH cord-354029-mp5r82g4 550 64 based base VBN cord-354029-mp5r82g4 550 65 identification identification NN cord-354029-mp5r82g4 550 66 of of IN cord-354029-mp5r82g4 550 67 an an DT cord-354029-mp5r82g4 550 68 inducer inducer NN cord-354029-mp5r82g4 550 69 of of IN cord-354029-mp5r82g4 550 70 the the DT cord-354029-mp5r82g4 550 71 low low JJ cord-354029-mp5r82g4 550 72 - - HYPH cord-354029-mp5r82g4 550 73 pH ph NN cord-354029-mp5r82g4 550 74 conformational conformational JJ cord-354029-mp5r82g4 550 75 change change NN cord-354029-mp5r82g4 550 76 in in IN cord-354029-mp5r82g4 550 77 the the DT cord-354029-mp5r82g4 550 78 influenza influenza NN cord-354029-mp5r82g4 550 79 virus virus NN cord-354029-mp5r82g4 550 80 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 550 81 : : : cord-354029-mp5r82g4 550 82 irreversible irreversible JJ cord-354029-mp5r82g4 550 83 inhibition inhibition NN cord-354029-mp5r82g4 550 84 of of IN cord-354029-mp5r82g4 550 85 infectivity infectivity NN cord-354029-mp5r82g4 550 86 Viral viral JJ cord-354029-mp5r82g4 550 87 entry entry NN cord-354029-mp5r82g4 550 88 and and CC cord-354029-mp5r82g4 550 89 receptors receptor NNS cord-354029-mp5r82g4 550 90 Entry Entry NNP cord-354029-mp5r82g4 550 91 of of IN cord-354029-mp5r82g4 550 92 Semliki Semliki NNP cord-354029-mp5r82g4 550 93 forest forest NN cord-354029-mp5r82g4 550 94 virus virus NN cord-354029-mp5r82g4 550 95 into into IN cord-354029-mp5r82g4 550 96 cells cell NNS cord-354029-mp5r82g4 550 97 : : : cord-354029-mp5r82g4 550 98 effects effect NNS cord-354029-mp5r82g4 550 99 of of IN cord-354029-mp5r82g4 550 100 concanamycin concanamycin NNS cord-354029-mp5r82g4 550 101 A a NN cord-354029-mp5r82g4 550 102 and and CC cord-354029-mp5r82g4 550 103 nigericin nigericin NNS cord-354029-mp5r82g4 550 104 on on IN cord-354029-mp5r82g4 550 105 viral viral JJ cord-354029-mp5r82g4 550 106 membrane membrane NN cord-354029-mp5r82g4 550 107 fusion fusion NN cord-354029-mp5r82g4 550 108 and and CC cord-354029-mp5r82g4 550 109 infection infection NN cord-354029-mp5r82g4 550 110 Mutational Mutational NNP cord-354029-mp5r82g4 550 111 analysis analysis NN cord-354029-mp5r82g4 550 112 of of IN cord-354029-mp5r82g4 550 113 the the DT cord-354029-mp5r82g4 550 114 putative putative JJ cord-354029-mp5r82g4 550 115 fusion fusion NN cord-354029-mp5r82g4 550 116 domain domain NN cord-354029-mp5r82g4 550 117 of of IN cord-354029-mp5r82g4 550 118 Ebola Ebola NNP cord-354029-mp5r82g4 550 119 virus virus NN cord-354029-mp5r82g4 550 120 glycoprotein glycoprotein NN cord-354029-mp5r82g4 550 121 Membrane Membrane NNP cord-354029-mp5r82g4 550 122 fusion fusion NN cord-354029-mp5r82g4 550 123 Functional functional JJ cord-354029-mp5r82g4 550 124 analysis analysis NN cord-354029-mp5r82g4 550 125 of of IN cord-354029-mp5r82g4 550 126 the the DT cord-354029-mp5r82g4 550 127 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 550 128 tail tail NN cord-354029-mp5r82g4 550 129 of of IN cord-354029-mp5r82g4 550 130 Moloney Moloney NNP cord-354029-mp5r82g4 550 131 murine murine JJ cord-354029-mp5r82g4 550 132 leukemia leukemia NN cord-354029-mp5r82g4 550 133 virus virus NN cord-354029-mp5r82g4 550 134 envelope envelope NN cord-354029-mp5r82g4 550 135 protein protein NN cord-354029-mp5r82g4 550 136 Covalent covalent JJ cord-354029-mp5r82g4 550 137 modifications modification NNS cord-354029-mp5r82g4 550 138 of of IN cord-354029-mp5r82g4 550 139 the the DT cord-354029-mp5r82g4 550 140 ebola ebola NNP cord-354029-mp5r82g4 550 141 virus virus NN cord-354029-mp5r82g4 550 142 glycoprotein glycoprotein NN cord-354029-mp5r82g4 550 143 Peptide Peptide NNP cord-354029-mp5r82g4 550 144 and and CC cord-354029-mp5r82g4 550 145 non non JJ cord-354029-mp5r82g4 550 146 - - JJ cord-354029-mp5r82g4 550 147 peptide peptide JJ cord-354029-mp5r82g4 550 148 HIV HIV NNP cord-354029-mp5r82g4 550 149 fusion fusion NN cord-354029-mp5r82g4 550 150 inhibitors inhibitor NNS cord-354029-mp5r82g4 551 1 A a DT cord-354029-mp5r82g4 551 2 core core NN cord-354029-mp5r82g4 551 3 trimer trimer NN cord-354029-mp5r82g4 551 4 of of IN cord-354029-mp5r82g4 551 5 the the DT cord-354029-mp5r82g4 551 6 paramyxovirus paramyxovirus NNP cord-354029-mp5r82g4 551 7 fusion fusion NN cord-354029-mp5r82g4 551 8 protein protein NN cord-354029-mp5r82g4 551 9 : : : cord-354029-mp5r82g4 551 10 parallels parallel NNS cord-354029-mp5r82g4 551 11 to to IN cord-354029-mp5r82g4 551 12 influenza influenza NN cord-354029-mp5r82g4 551 13 virus virus NN cord-354029-mp5r82g4 551 14 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 551 15 and and CC cord-354029-mp5r82g4 551 16 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 551 17 gp41 gp41 NNP cord-354029-mp5r82g4 551 18 Membrane Membrane NNP cord-354029-mp5r82g4 551 19 structure structure NN cord-354029-mp5r82g4 551 20 of of IN cord-354029-mp5r82g4 551 21 the the DT cord-354029-mp5r82g4 551 22 human human JJ cord-354029-mp5r82g4 551 23 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 551 24 virus virus NN cord-354029-mp5r82g4 551 25 gp41 gp41 NNP cord-354029-mp5r82g4 551 26 fusion fusion NN cord-354029-mp5r82g4 551 27 domain domain NN cord-354029-mp5r82g4 551 28 by by IN cord-354029-mp5r82g4 551 29 molecular molecular JJ cord-354029-mp5r82g4 551 30 dynamics dynamic NNS cord-354029-mp5r82g4 551 31 simulation simulation NN cord-354029-mp5r82g4 551 32 Structural structural JJ cord-354029-mp5r82g4 551 33 features feature NNS cord-354029-mp5r82g4 551 34 of of IN cord-354029-mp5r82g4 551 35 membrane membrane NN cord-354029-mp5r82g4 551 36 fusion fusion NN cord-354029-mp5r82g4 551 37 between between IN cord-354029-mp5r82g4 551 38 influenza influenza NN cord-354029-mp5r82g4 551 39 virus virus NN cord-354029-mp5r82g4 551 40 and and CC cord-354029-mp5r82g4 551 41 liposome liposome NN cord-354029-mp5r82g4 551 42 as as IN cord-354029-mp5r82g4 551 43 revealed reveal VBN cord-354029-mp5r82g4 551 44 by by IN cord-354029-mp5r82g4 551 45 quick quick RB cord-354029-mp5r82g4 551 46 - - HYPH cord-354029-mp5r82g4 551 47 freezing freeze VBG cord-354029-mp5r82g4 551 48 electron electron NN cord-354029-mp5r82g4 551 49 microscopy microscopy NN cord-354029-mp5r82g4 552 1 Intermonomer Intermonomer NNP cord-354029-mp5r82g4 552 2 disulfide disulfide NN cord-354029-mp5r82g4 552 3 bonds bond NNS cord-354029-mp5r82g4 552 4 impair impair VBP cord-354029-mp5r82g4 552 5 the the DT cord-354029-mp5r82g4 552 6 fusion fusion NN cord-354029-mp5r82g4 552 7 activity activity NN cord-354029-mp5r82g4 552 8 of of IN cord-354029-mp5r82g4 552 9 influenza influenza NN cord-354029-mp5r82g4 552 10 virus virus NN cord-354029-mp5r82g4 552 11 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 552 12 Lipid Lipid NNP cord-354029-mp5r82g4 552 13 - - HYPH cord-354029-mp5r82g4 552 14 anchored anchor VBN cord-354029-mp5r82g4 552 15 influenza influenza NN cord-354029-mp5r82g4 552 16 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 552 17 promotes promote VBZ cord-354029-mp5r82g4 552 18 hemifusion hemifusion NN cord-354029-mp5r82g4 552 19 , , , cord-354029-mp5r82g4 552 20 not not RB cord-354029-mp5r82g4 552 21 complete complete JJ cord-354029-mp5r82g4 552 22 fusion fusion NN cord-354029-mp5r82g4 552 23 Membrane membrane NN cord-354029-mp5r82g4 552 24 fusion fusion NN cord-354029-mp5r82g4 552 25 and and CC cord-354029-mp5r82g4 552 26 the the DT cord-354029-mp5r82g4 552 27 alphavirus alphavirus NNP cord-354029-mp5r82g4 552 28 life life NN cord-354029-mp5r82g4 552 29 cycle cycle NN cord-354029-mp5r82g4 552 30 Mechanisms Mechanisms NNPS cord-354029-mp5r82g4 552 31 of of IN cord-354029-mp5r82g4 552 32 mutations mutation NNS cord-354029-mp5r82g4 552 33 inhibiting inhibit VBG cord-354029-mp5r82g4 552 34 fusion fusion NN cord-354029-mp5r82g4 552 35 and and CC cord-354029-mp5r82g4 552 36 infection infection NN cord-354029-mp5r82g4 552 37 by by IN cord-354029-mp5r82g4 552 38 Semliki Semliki NNP cord-354029-mp5r82g4 552 39 Forest Forest NNP cord-354029-mp5r82g4 552 40 virus virus NN cord-354029-mp5r82g4 553 1 Specific specific JJ cord-354029-mp5r82g4 553 2 roles role NNS cord-354029-mp5r82g4 553 3 for for IN cord-354029-mp5r82g4 553 4 lipids lipid NNS cord-354029-mp5r82g4 553 5 in in IN cord-354029-mp5r82g4 553 6 virus virus NN cord-354029-mp5r82g4 553 7 fusion fusion NN cord-354029-mp5r82g4 553 8 and and CC cord-354029-mp5r82g4 553 9 exit exit NN cord-354029-mp5r82g4 553 10 . . . cord-354029-mp5r82g4 554 1 Examples example NNS cord-354029-mp5r82g4 554 2 from from IN cord-354029-mp5r82g4 554 3 the the DT cord-354029-mp5r82g4 554 4 alphaviruses alphavirus NNS cord-354029-mp5r82g4 555 1 Potent potent JJ cord-354029-mp5r82g4 555 2 suppression suppression NN cord-354029-mp5r82g4 555 3 of of IN cord-354029-mp5r82g4 555 4 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 555 5 replication replication NN cord-354029-mp5r82g4 555 6 in in IN cord-354029-mp5r82g4 555 7 humans human NNS cord-354029-mp5r82g4 555 8 by by IN cord-354029-mp5r82g4 555 9 T-20 T-20 NNP cord-354029-mp5r82g4 555 10 , , , cord-354029-mp5r82g4 555 11 a a DT cord-354029-mp5r82g4 555 12 peptide peptide JJ cord-354029-mp5r82g4 555 13 inhibitor inhibitor NN cord-354029-mp5r82g4 555 14 of of IN cord-354029-mp5r82g4 555 15 gp41-mediated gp41-mediated NNP cord-354029-mp5r82g4 556 1 virus virus NN cord-354029-mp5r82g4 556 2 entry entry NN cord-354029-mp5r82g4 556 3 Human Human NNP cord-354029-mp5r82g4 556 4 T T NNP cord-354029-mp5r82g4 556 5 - - HYPH cord-354029-mp5r82g4 556 6 cell cell NN cord-354029-mp5r82g4 556 7 leukemia leukemia NN cord-354029-mp5r82g4 556 8 virus virus NN cord-354029-mp5r82g4 556 9 type type NN cord-354029-mp5r82g4 556 10 1 1 CD cord-354029-mp5r82g4 556 11 envelope envelope NN cord-354029-mp5r82g4 556 12 - - HYPH cord-354029-mp5r82g4 556 13 mediated mediate VBN cord-354029-mp5r82g4 556 14 syncytium syncytium NN cord-354029-mp5r82g4 556 15 formation formation NN cord-354029-mp5r82g4 556 16 can can MD cord-354029-mp5r82g4 556 17 be be VB cord-354029-mp5r82g4 556 18 activated activate VBN cord-354029-mp5r82g4 556 19 in in IN cord-354029-mp5r82g4 556 20 resistant resistant JJ cord-354029-mp5r82g4 556 21 mammalian mammalian JJ cord-354029-mp5r82g4 556 22 cell cell NN cord-354029-mp5r82g4 556 23 lines line NNS cord-354029-mp5r82g4 556 24 by by IN cord-354029-mp5r82g4 556 25 a a DT cord-354029-mp5r82g4 556 26 carboxy carboxy JJ cord-354029-mp5r82g4 556 27 - - HYPH cord-354029-mp5r82g4 556 28 terminal terminal NN cord-354029-mp5r82g4 556 29 truncation truncation NN cord-354029-mp5r82g4 556 30 of of IN cord-354029-mp5r82g4 556 31 the the DT cord-354029-mp5r82g4 556 32 envelope envelope NN cord-354029-mp5r82g4 556 33 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 556 34 domain domain NN cord-354029-mp5r82g4 556 35 Fusion fusion NN cord-354029-mp5r82g4 556 36 peptides peptide NNS cord-354029-mp5r82g4 556 37 derived derive VBN cord-354029-mp5r82g4 556 38 from from IN cord-354029-mp5r82g4 556 39 the the DT cord-354029-mp5r82g4 556 40 HIV HIV NNP cord-354029-mp5r82g4 556 41 type type NN cord-354029-mp5r82g4 556 42 1 1 CD cord-354029-mp5r82g4 556 43 glycoprotein glycoprotein NN cord-354029-mp5r82g4 556 44 41 41 CD cord-354029-mp5r82g4 556 45 associate associate NN cord-354029-mp5r82g4 556 46 within within IN cord-354029-mp5r82g4 556 47 phospholipid phospholipid NN cord-354029-mp5r82g4 556 48 membranes membrane NNS cord-354029-mp5r82g4 556 49 and and CC cord-354029-mp5r82g4 556 50 inhibit inhibit VBP cord-354029-mp5r82g4 556 51 cell cell NN cord-354029-mp5r82g4 556 52 - - HYPH cord-354029-mp5r82g4 556 53 cell cell NN cord-354029-mp5r82g4 556 54 fusion fusion NN cord-354029-mp5r82g4 556 55 . . . cord-354029-mp5r82g4 557 1 Structure structure NN cord-354029-mp5r82g4 557 2 - - HYPH cord-354029-mp5r82g4 557 3 function function NN cord-354029-mp5r82g4 557 4 study study NN cord-354029-mp5r82g4 557 5 Mode mode NN cord-354029-mp5r82g4 557 6 of of IN cord-354029-mp5r82g4 557 7 action action NN cord-354029-mp5r82g4 557 8 of of IN cord-354029-mp5r82g4 557 9 an an DT cord-354029-mp5r82g4 557 10 antiviral antiviral JJ cord-354029-mp5r82g4 557 11 peptide peptide NN cord-354029-mp5r82g4 557 12 from from IN cord-354029-mp5r82g4 557 13 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 557 14 . . . cord-354029-mp5r82g4 558 1 Inhibition inhibition NN cord-354029-mp5r82g4 558 2 at at IN cord-354029-mp5r82g4 558 3 a a DT cord-354029-mp5r82g4 558 4 post post JJ cord-354029-mp5r82g4 558 5 - - JJ cord-354029-mp5r82g4 558 6 lipid lipid JJ cord-354029-mp5r82g4 558 7 mixing mixing NN cord-354029-mp5r82g4 558 8 stage stage NN cord-354029-mp5r82g4 559 1 A a DT cord-354029-mp5r82g4 559 2 leucine leucine NN cord-354029-mp5r82g4 559 3 zipper zipper NN cord-354029-mp5r82g4 559 4 - - HYPH cord-354029-mp5r82g4 559 5 like like JJ cord-354029-mp5r82g4 559 6 sequence sequence NN cord-354029-mp5r82g4 559 7 from from IN cord-354029-mp5r82g4 559 8 the the DT cord-354029-mp5r82g4 559 9 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 559 10 tail tail NN cord-354029-mp5r82g4 559 11 of of IN cord-354029-mp5r82g4 559 12 the the DT cord-354029-mp5r82g4 559 13 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 559 14 envelope envelope NN cord-354029-mp5r82g4 559 15 glycoprotein glycoprotein NN cord-354029-mp5r82g4 559 16 binds bind VBZ cord-354029-mp5r82g4 559 17 and and CC cord-354029-mp5r82g4 559 18 perturbs perturb VBZ cord-354029-mp5r82g4 559 19 lipid lipid NN cord-354029-mp5r82g4 559 20 bilayers bilayer NNS cord-354029-mp5r82g4 559 21 Conformational Conformational NNP cord-354029-mp5r82g4 559 22 intermediates intermediate NNS cord-354029-mp5r82g4 559 23 and and CC cord-354029-mp5r82g4 559 24 fusion fusion NN cord-354029-mp5r82g4 559 25 activity activity NN cord-354029-mp5r82g4 559 26 of of IN cord-354029-mp5r82g4 559 27 influenza influenza NN cord-354029-mp5r82g4 559 28 virus virus NN cord-354029-mp5r82g4 559 29 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 559 30 Segregation Segregation NNP cord-354029-mp5r82g4 559 31 of of IN cord-354029-mp5r82g4 559 32 CD4 CD4 NNP cord-354029-mp5r82g4 559 33 and and CC cord-354029-mp5r82g4 559 34 CXCR4 CXCR4 NNS cord-354029-mp5r82g4 559 35 into into IN cord-354029-mp5r82g4 559 36 distinct distinct JJ cord-354029-mp5r82g4 559 37 lipid lipid NN cord-354029-mp5r82g4 559 38 microdomains microdomain NNS cord-354029-mp5r82g4 559 39 in in IN cord-354029-mp5r82g4 559 40 T t NN cord-354029-mp5r82g4 559 41 lymphocytes lymphocyte NNS cord-354029-mp5r82g4 560 1 suggests suggest VBZ cord-354029-mp5r82g4 560 2 a a DT cord-354029-mp5r82g4 560 3 mechanism mechanism NN cord-354029-mp5r82g4 560 4 for for IN cord-354029-mp5r82g4 560 5 membrane membrane NN cord-354029-mp5r82g4 560 6 destabilization destabilization NN cord-354029-mp5r82g4 560 7 by by IN cord-354029-mp5r82g4 560 8 human human JJ cord-354029-mp5r82g4 560 9 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 560 10 virus virus NN cord-354029-mp5r82g4 560 11 Modification modification NN cord-354029-mp5r82g4 560 12 of of IN cord-354029-mp5r82g4 560 13 the the DT cord-354029-mp5r82g4 560 14 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 560 15 domain domain NN cord-354029-mp5r82g4 560 16 of of IN cord-354029-mp5r82g4 560 17 influenza influenza NN cord-354029-mp5r82g4 560 18 virus virus NN cord-354029-mp5r82g4 560 19 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 560 20 affects affect VBZ cord-354029-mp5r82g4 560 21 enlargement enlargement NN cord-354029-mp5r82g4 560 22 of of IN cord-354029-mp5r82g4 560 23 the the DT cord-354029-mp5r82g4 560 24 fusion fusion NN cord-354029-mp5r82g4 560 25 pore pore NN cord-354029-mp5r82g4 560 26 The the DT cord-354029-mp5r82g4 560 27 protein protein NN cord-354029-mp5r82g4 560 28 coat coat NN cord-354029-mp5r82g4 560 29 in in IN cord-354029-mp5r82g4 560 30 membrane membrane NN cord-354029-mp5r82g4 560 31 fusion fusion NN cord-354029-mp5r82g4 560 32 : : : cord-354029-mp5r82g4 560 33 lessons lesson NNS cord-354029-mp5r82g4 560 34 from from IN cord-354029-mp5r82g4 560 35 fission fission NN cord-354029-mp5r82g4 560 36 Stalk stalk NN cord-354029-mp5r82g4 560 37 model model NN cord-354029-mp5r82g4 560 38 of of IN cord-354029-mp5r82g4 560 39 membrane membrane NN cord-354029-mp5r82g4 560 40 fusion fusion NN cord-354029-mp5r82g4 560 41 : : : cord-354029-mp5r82g4 560 42 solution solution NN cord-354029-mp5r82g4 560 43 of of IN cord-354029-mp5r82g4 560 44 energy energy NN cord-354029-mp5r82g4 560 45 crisis crisis NN cord-354029-mp5r82g4 560 46 Structure Structure NNP cord-354029-mp5r82g4 560 47 of of IN cord-354029-mp5r82g4 560 48 dengue dengue NN cord-354029-mp5r82g4 560 49 virus virus NN cord-354029-mp5r82g4 560 50 : : : cord-354029-mp5r82g4 560 51 implications implication NNS cord-354029-mp5r82g4 560 52 for for IN cord-354029-mp5r82g4 560 53 flavivirus flavivirus NNP cord-354029-mp5r82g4 560 54 organization organization NN cord-354029-mp5r82g4 560 55 , , , cord-354029-mp5r82g4 560 56 maturation maturation NN cord-354029-mp5r82g4 560 57 , , , cord-354029-mp5r82g4 560 58 and and CC cord-354029-mp5r82g4 560 59 fusion fusion NN cord-354029-mp5r82g4 560 60 Structure structure NN cord-354029-mp5r82g4 560 61 of of IN cord-354029-mp5r82g4 560 62 an an DT cord-354029-mp5r82g4 560 63 HIV HIV NNP cord-354029-mp5r82g4 560 64 gp120 gp120 NNP cord-354029-mp5r82g4 560 65 envelope envelope NN cord-354029-mp5r82g4 560 66 glycoprotein glycoprotein NN cord-354029-mp5r82g4 560 67 in in IN cord-354029-mp5r82g4 560 68 complex complex NN cord-354029-mp5r82g4 560 69 with with IN cord-354029-mp5r82g4 560 70 the the DT cord-354029-mp5r82g4 560 71 CD4 CD4 NNP cord-354029-mp5r82g4 560 72 receptor receptor NN cord-354029-mp5r82g4 560 73 and and CC cord-354029-mp5r82g4 560 74 a a DT cord-354029-mp5r82g4 560 75 neutralizing neutralize VBG cord-354029-mp5r82g4 560 76 human human JJ cord-354029-mp5r82g4 560 77 antibody antibody NN cord-354029-mp5r82g4 560 78 Paramyxovirus Paramyxovirus NNP cord-354029-mp5r82g4 560 79 fusion fusion NN cord-354029-mp5r82g4 560 80 : : : cord-354029-mp5r82g4 560 81 a a DT cord-354029-mp5r82g4 560 82 hypothesis hypothesis NN cord-354029-mp5r82g4 560 83 for for IN cord-354029-mp5r82g4 560 84 changes change NNS cord-354029-mp5r82g4 560 85 Peptides peptide NNS cord-354029-mp5r82g4 560 86 from from IN cord-354029-mp5r82g4 560 87 conserved conserved JJ cord-354029-mp5r82g4 560 88 regions region NNS cord-354029-mp5r82g4 560 89 of of IN cord-354029-mp5r82g4 560 90 paramyxovirus paramyxovirus JJ cord-354029-mp5r82g4 560 91 fusion fusion NN cord-354029-mp5r82g4 560 92 ( ( -LRB- cord-354029-mp5r82g4 560 93 F F NNP cord-354029-mp5r82g4 560 94 ) ) -RRB- cord-354029-mp5r82g4 560 95 proteins protein NNS cord-354029-mp5r82g4 560 96 are be VBP cord-354029-mp5r82g4 560 97 potent potent JJ cord-354029-mp5r82g4 560 98 inhibitors inhibitor NNS cord-354029-mp5r82g4 560 99 of of IN cord-354029-mp5r82g4 560 100 viral viral JJ cord-354029-mp5r82g4 560 101 fusion fusion NN cord-354029-mp5r82g4 560 102 Activation activation NN cord-354029-mp5r82g4 560 103 of of IN cord-354029-mp5r82g4 560 104 membrane membrane NN cord-354029-mp5r82g4 560 105 fusion fusion NN cord-354029-mp5r82g4 560 106 by by IN cord-354029-mp5r82g4 560 107 murine murine JJ cord-354029-mp5r82g4 560 108 leukemia leukemia NN cord-354029-mp5r82g4 560 109 viruses virus NNS cord-354029-mp5r82g4 560 110 is be VBZ cord-354029-mp5r82g4 560 111 controlled control VBN cord-354029-mp5r82g4 560 112 in in IN cord-354029-mp5r82g4 560 113 cis cis NNP cord-354029-mp5r82g4 560 114 or or CC cord-354029-mp5r82g4 560 115 in in IN cord-354029-mp5r82g4 560 116 trans trans NNP cord-354029-mp5r82g4 560 117 by by IN cord-354029-mp5r82g4 560 118 interactions interaction NNS cord-354029-mp5r82g4 560 119 between between IN cord-354029-mp5r82g4 560 120 the the DT cord-354029-mp5r82g4 560 121 receptor receptor NN cord-354029-mp5r82g4 560 122 - - HYPH cord-354029-mp5r82g4 560 123 binding bind VBG cord-354029-mp5r82g4 560 124 domain domain NN cord-354029-mp5r82g4 560 125 and and CC cord-354029-mp5r82g4 560 126 a a DT cord-354029-mp5r82g4 560 127 conserved conserved JJ cord-354029-mp5r82g4 560 128 disulfide disulfide NN cord-354029-mp5r82g4 560 129 loop loop NN cord-354029-mp5r82g4 560 130 of of IN cord-354029-mp5r82g4 560 131 the the DT cord-354029-mp5r82g4 560 132 carboxy carboxy JJ cord-354029-mp5r82g4 560 133 terminus terminus NN cord-354029-mp5r82g4 560 134 of of IN cord-354029-mp5r82g4 560 135 the the DT cord-354029-mp5r82g4 560 136 surface surface NN cord-354029-mp5r82g4 560 137 glycoprotein glycoprotein NN cord-354029-mp5r82g4 560 138 A a DT cord-354029-mp5r82g4 560 139 proline proline JJ cord-354029-mp5r82g4 560 140 - - HYPH cord-354029-mp5r82g4 560 141 rich rich JJ cord-354029-mp5r82g4 560 142 motif motif NN cord-354029-mp5r82g4 560 143 downstream downstream RB cord-354029-mp5r82g4 560 144 of of IN cord-354029-mp5r82g4 560 145 the the DT cord-354029-mp5r82g4 560 146 receptor receptor NN cord-354029-mp5r82g4 560 147 binding bind VBG cord-354029-mp5r82g4 560 148 domain domain NN cord-354029-mp5r82g4 560 149 modulates modulate VBZ cord-354029-mp5r82g4 560 150 conformation conformation NN cord-354029-mp5r82g4 560 151 and and CC cord-354029-mp5r82g4 560 152 fusogenicity fusogenicity NN cord-354029-mp5r82g4 560 153 of of IN cord-354029-mp5r82g4 560 154 murine murine JJ cord-354029-mp5r82g4 560 155 retroviral retroviral NN cord-354029-mp5r82g4 560 156 envelopes envelope NNS cord-354029-mp5r82g4 561 1 The the DT cord-354029-mp5r82g4 561 2 fusion fusion NN cord-354029-mp5r82g4 561 3 glycoprotein glycoprotein NN cord-354029-mp5r82g4 561 4 shell shell NN cord-354029-mp5r82g4 561 5 of of IN cord-354029-mp5r82g4 561 6 Semliki Semliki NNP cord-354029-mp5r82g4 561 7 Forest Forest NNP cord-354029-mp5r82g4 561 8 virus virus NN cord-354029-mp5r82g4 561 9 : : : cord-354029-mp5r82g4 561 10 an an DT cord-354029-mp5r82g4 561 11 icosahedral icosahedral JJ cord-354029-mp5r82g4 561 12 assembly assembly NN cord-354029-mp5r82g4 561 13 primed prime VBN cord-354029-mp5r82g4 561 14 for for IN cord-354029-mp5r82g4 561 15 fusogenic fusogenic JJ cord-354029-mp5r82g4 561 16 activation activation NN cord-354029-mp5r82g4 561 17 at at IN cord-354029-mp5r82g4 561 18 endosomal endosomal NNP cord-354029-mp5r82g4 561 19 pH pH NNP cord-354029-mp5r82g4 561 20 Mutations Mutations NNP cord-354029-mp5r82g4 561 21 in in IN cord-354029-mp5r82g4 561 22 the the DT cord-354029-mp5r82g4 561 23 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 561 24 tail tail NN cord-354029-mp5r82g4 561 25 of of IN cord-354029-mp5r82g4 561 26 murine murine JJ cord-354029-mp5r82g4 561 27 leukemia leukemia NN cord-354029-mp5r82g4 561 28 virus virus NN cord-354029-mp5r82g4 561 29 envelope envelope NN cord-354029-mp5r82g4 561 30 protein protein NN cord-354029-mp5r82g4 561 31 suppress suppress VB cord-354029-mp5r82g4 561 32 fusion fusion NN cord-354029-mp5r82g4 561 33 inhibition inhibition NN cord-354029-mp5r82g4 561 34 by by IN cord-354029-mp5r82g4 561 35 R R NNP cord-354029-mp5r82g4 561 36 peptide peptide NN cord-354029-mp5r82g4 561 37 Mutation Mutation NNP cord-354029-mp5r82g4 561 38 analysis analysis NN cord-354029-mp5r82g4 561 39 of of IN cord-354029-mp5r82g4 561 40 the the DT cord-354029-mp5r82g4 561 41 vesicular vesicular JJ cord-354029-mp5r82g4 561 42 stomatitis stomatitis NN cord-354029-mp5r82g4 561 43 virus virus NN cord-354029-mp5r82g4 561 44 glycoprotein glycoprotein NN cord-354029-mp5r82g4 561 45 G g NN cord-354029-mp5r82g4 561 46 for for IN cord-354029-mp5r82g4 561 47 membrane membrane NN cord-354029-mp5r82g4 561 48 fusion fusion NN cord-354029-mp5r82g4 561 49 domains domain NNS cord-354029-mp5r82g4 561 50 Thermodynamics thermodynamic NNS cord-354029-mp5r82g4 561 51 of of IN cord-354029-mp5r82g4 561 52 fusion fusion NN cord-354029-mp5r82g4 561 53 peptide peptide NN cord-354029-mp5r82g4 561 54 - - HYPH cord-354029-mp5r82g4 561 55 membrane membrane NN cord-354029-mp5r82g4 561 56 interactions interaction NNS cord-354029-mp5r82g4 562 1 A a DT cord-354029-mp5r82g4 562 2 trimeric trimeric JJ cord-354029-mp5r82g4 562 3 structural structural JJ cord-354029-mp5r82g4 562 4 domain domain NN cord-354029-mp5r82g4 562 5 of of IN cord-354029-mp5r82g4 562 6 the the DT cord-354029-mp5r82g4 562 7 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 562 8 transmembrane transmembrane NN cord-354029-mp5r82g4 562 9 glycoprotein glycoprotein NN cord-354029-mp5r82g4 562 10 Importance importance NN cord-354029-mp5r82g4 562 11 of of IN cord-354029-mp5r82g4 562 12 the the DT cord-354029-mp5r82g4 562 13 intracytoplasmic intracytoplasmic JJ cord-354029-mp5r82g4 562 14 domain domain NN cord-354029-mp5r82g4 562 15 of of IN cord-354029-mp5r82g4 562 16 the the DT cord-354029-mp5r82g4 562 17 simian simian JJ cord-354029-mp5r82g4 562 18 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 562 19 virus virus NN cord-354029-mp5r82g4 562 20 ( ( -LRB- cord-354029-mp5r82g4 562 21 SIV SIV NNP cord-354029-mp5r82g4 562 22 ) ) -RRB- cord-354029-mp5r82g4 562 23 envelope envelope NN cord-354029-mp5r82g4 562 24 glycoprotein glycoprotein NN cord-354029-mp5r82g4 562 25 for for IN cord-354029-mp5r82g4 562 26 pathogenesis pathogenesis NN cord-354029-mp5r82g4 562 27 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 562 28 envelope envelope NN cord-354029-mp5r82g4 562 29 proteins protein NNS cord-354029-mp5r82g4 562 30 complete complete VBP cord-354029-mp5r82g4 562 31 their -PRON- PRP$ cord-354029-mp5r82g4 562 32 folding folding NN cord-354029-mp5r82g4 562 33 into into IN cord-354029-mp5r82g4 562 34 six six CD cord-354029-mp5r82g4 562 35 - - HYPH cord-354029-mp5r82g4 562 36 helix helix NN cord-354029-mp5r82g4 562 37 bundles bundle NNS cord-354029-mp5r82g4 562 38 immediately immediately RB cord-354029-mp5r82g4 562 39 after after IN cord-354029-mp5r82g4 562 40 fusion fusion NN cord-354029-mp5r82g4 562 41 pore pore NN cord-354029-mp5r82g4 562 42 formation formation NN cord-354029-mp5r82g4 562 43 Synchronized synchronize VBN cord-354029-mp5r82g4 562 44 activation activation NN cord-354029-mp5r82g4 562 45 and and CC cord-354029-mp5r82g4 562 46 refolding refolding NN cord-354029-mp5r82g4 562 47 of of IN cord-354029-mp5r82g4 562 48 influenza influenza NN cord-354029-mp5r82g4 562 49 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 562 50 in in IN cord-354029-mp5r82g4 562 51 multimeric multimeric NNP cord-354029-mp5r82g4 562 52 fusion fusion NN cord-354029-mp5r82g4 562 53 machines machine NNS cord-354029-mp5r82g4 562 54 Membrane Membrane NNP cord-354029-mp5r82g4 562 55 fusion fusion NN cord-354029-mp5r82g4 562 56 mediated mediate VBN cord-354029-mp5r82g4 562 57 by by IN cord-354029-mp5r82g4 562 58 baculovirus baculovirus NNP cord-354029-mp5r82g4 562 59 gp64 gp64 RB cord-354029-mp5r82g4 562 60 involves involve VBZ cord-354029-mp5r82g4 562 61 assembly assembly NN cord-354029-mp5r82g4 562 62 of of IN cord-354029-mp5r82g4 562 63 stable stable JJ cord-354029-mp5r82g4 562 64 gp64 gp64 JJ cord-354029-mp5r82g4 562 65 trimers trimer NNS cord-354029-mp5r82g4 562 66 into into IN cord-354029-mp5r82g4 562 67 multiprotein multiprotein NNP cord-354029-mp5r82g4 562 68 aggregates aggregate VBZ cord-354029-mp5r82g4 562 69 Common common JJ cord-354029-mp5r82g4 562 70 properties property NNS cord-354029-mp5r82g4 562 71 of of IN cord-354029-mp5r82g4 562 72 fusion fusion NN cord-354029-mp5r82g4 562 73 peptides peptide NNS cord-354029-mp5r82g4 562 74 from from IN cord-354029-mp5r82g4 562 75 diverse diverse JJ cord-354029-mp5r82g4 562 76 systems system NNS cord-354029-mp5r82g4 562 77 Role role NN cord-354029-mp5r82g4 562 78 of of IN cord-354029-mp5r82g4 562 79 the the DT cord-354029-mp5r82g4 562 80 N n CD cord-354029-mp5r82g4 562 81 - - HYPH cord-354029-mp5r82g4 562 82 terminal terminal NN cord-354029-mp5r82g4 562 83 peptides peptide NNS cord-354029-mp5r82g4 562 84 of of IN cord-354029-mp5r82g4 562 85 viral viral JJ cord-354029-mp5r82g4 562 86 envelope envelope NN cord-354029-mp5r82g4 562 87 proteins protein NNS cord-354029-mp5r82g4 562 88 in in IN cord-354029-mp5r82g4 562 89 membrane membrane NN cord-354029-mp5r82g4 562 90 fusion fusion NN cord-354029-mp5r82g4 562 91 Sequential sequential JJ cord-354029-mp5r82g4 562 92 roles role NNS cord-354029-mp5r82g4 562 93 of of IN cord-354029-mp5r82g4 562 94 receptor receptor NN cord-354029-mp5r82g4 562 95 binding binding NN cord-354029-mp5r82g4 562 96 and and CC cord-354029-mp5r82g4 562 97 low low JJ cord-354029-mp5r82g4 562 98 pH ph NN cord-354029-mp5r82g4 562 99 in in IN cord-354029-mp5r82g4 562 100 forming form VBG cord-354029-mp5r82g4 562 101 prehairpin prehairpin NN cord-354029-mp5r82g4 562 102 and and CC cord-354029-mp5r82g4 562 103 hairpin hairpin NN cord-354029-mp5r82g4 562 104 conformations conformation NNS cord-354029-mp5r82g4 562 105 of of IN cord-354029-mp5r82g4 562 106 an an DT cord-354029-mp5r82g4 562 107 avian avian JJ cord-354029-mp5r82g4 562 108 retroviral retroviral NN cord-354029-mp5r82g4 562 109 envelope envelope NN cord-354029-mp5r82g4 562 110 glycoprotein glycoprotein NN cord-354029-mp5r82g4 562 111 The the DT cord-354029-mp5r82g4 562 112 pH pH NNP cord-354029-mp5r82g4 562 113 independence independence NN cord-354029-mp5r82g4 562 114 of of IN cord-354029-mp5r82g4 562 115 mammalian mammalian JJ cord-354029-mp5r82g4 562 116 retrovirus retrovirus NN cord-354029-mp5r82g4 562 117 infection infection NN cord-354029-mp5r82g4 563 1 Newcastle Newcastle NNP cord-354029-mp5r82g4 563 2 disease disease NN cord-354029-mp5r82g4 563 3 virus virus NN cord-354029-mp5r82g4 563 4 HN HN NNP cord-354029-mp5r82g4 563 5 protein protein NN cord-354029-mp5r82g4 563 6 alters alter VBZ cord-354029-mp5r82g4 563 7 the the DT cord-354029-mp5r82g4 563 8 conformation conformation NN cord-354029-mp5r82g4 563 9 of of IN cord-354029-mp5r82g4 563 10 the the DT cord-354029-mp5r82g4 563 11 F F NNP cord-354029-mp5r82g4 563 12 protein protein NN cord-354029-mp5r82g4 563 13 at at IN cord-354029-mp5r82g4 563 14 cell cell NN cord-354029-mp5r82g4 563 15 surfaces surface NNS cord-354029-mp5r82g4 563 16 Inner Inner NNP cord-354029-mp5r82g4 563 17 but but CC cord-354029-mp5r82g4 563 18 not not RB cord-354029-mp5r82g4 563 19 outer outer JJ cord-354029-mp5r82g4 563 20 membrane membrane NN cord-354029-mp5r82g4 563 21 leaflets leaflet NNS cord-354029-mp5r82g4 563 22 control control VBP cord-354029-mp5r82g4 563 23 the the DT cord-354029-mp5r82g4 563 24 transition transition NN cord-354029-mp5r82g4 563 25 from from IN cord-354029-mp5r82g4 563 26 glycosylphosphatidylinositol glycosylphosphatidylinositol NNP cord-354029-mp5r82g4 563 27 - - HYPH cord-354029-mp5r82g4 563 28 anchored anchor VBN cord-354029-mp5r82g4 563 29 influenza influenza NN cord-354029-mp5r82g4 563 30 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 563 31 - - HYPH cord-354029-mp5r82g4 563 32 induced induce VBN cord-354029-mp5r82g4 563 33 hemifusion hemifusion NN cord-354029-mp5r82g4 563 34 to to IN cord-354029-mp5r82g4 563 35 full full JJ cord-354029-mp5r82g4 563 36 fusion fusion NN cord-354029-mp5r82g4 564 1 The the DT cord-354029-mp5r82g4 564 2 role role NN cord-354029-mp5r82g4 564 3 of of IN cord-354029-mp5r82g4 564 4 the the DT cord-354029-mp5r82g4 564 5 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 564 6 tail tail NN cord-354029-mp5r82g4 564 7 region region NN cord-354029-mp5r82g4 564 8 of of IN cord-354029-mp5r82g4 564 9 influenza influenza NN cord-354029-mp5r82g4 564 10 virus virus NN cord-354029-mp5r82g4 564 11 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 564 12 in in IN cord-354029-mp5r82g4 564 13 formation formation NN cord-354029-mp5r82g4 564 14 and and CC cord-354029-mp5r82g4 564 15 growth growth NN cord-354029-mp5r82g4 564 16 of of IN cord-354029-mp5r82g4 564 17 fusion fusion NN cord-354029-mp5r82g4 564 18 pores pore NNS cord-354029-mp5r82g4 564 19 Evidence evidence NN cord-354029-mp5r82g4 564 20 that that IN cord-354029-mp5r82g4 564 21 the the DT cord-354029-mp5r82g4 564 22 transition transition NN cord-354029-mp5r82g4 564 23 of of IN cord-354029-mp5r82g4 564 24 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 564 25 gp41 gp41 NNP cord-354029-mp5r82g4 564 26 into into IN cord-354029-mp5r82g4 564 27 a a DT cord-354029-mp5r82g4 564 28 six six CD cord-354029-mp5r82g4 564 29 - - HYPH cord-354029-mp5r82g4 564 30 helix helix NN cord-354029-mp5r82g4 564 31 bundle bundle NN cord-354029-mp5r82g4 564 32 , , , cord-354029-mp5r82g4 564 33 not not RB cord-354029-mp5r82g4 564 34 the the DT cord-354029-mp5r82g4 564 35 bundle bundle NN cord-354029-mp5r82g4 564 36 configuration configuration NN cord-354029-mp5r82g4 564 37 , , , cord-354029-mp5r82g4 564 38 induces induce VBZ cord-354029-mp5r82g4 564 39 membrane membrane NN cord-354029-mp5r82g4 564 40 fusion fusion NN cord-354029-mp5r82g4 565 1 A a DT cord-354029-mp5r82g4 565 2 point point NN cord-354029-mp5r82g4 565 3 mutation mutation NN cord-354029-mp5r82g4 565 4 in in IN cord-354029-mp5r82g4 565 5 the the DT cord-354029-mp5r82g4 565 6 transmembrane transmembrane NN cord-354029-mp5r82g4 565 7 domain domain NN cord-354029-mp5r82g4 565 8 of of IN cord-354029-mp5r82g4 565 9 the the DT cord-354029-mp5r82g4 565 10 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 565 11 of of IN cord-354029-mp5r82g4 565 12 influenza influenza NNP cord-354029-mp5r82g4 565 13 virus virus NN cord-354029-mp5r82g4 565 14 stabilizes stabilize VBZ cord-354029-mp5r82g4 565 15 a a DT cord-354029-mp5r82g4 565 16 hemifusion hemifusion NN cord-354029-mp5r82g4 565 17 intermediate intermediate JJ cord-354029-mp5r82g4 565 18 that that WDT cord-354029-mp5r82g4 565 19 can can MD cord-354029-mp5r82g4 565 20 transit transit VB cord-354029-mp5r82g4 565 21 to to IN cord-354029-mp5r82g4 565 22 fusion fusion NN cord-354029-mp5r82g4 565 23 Structure Structure NNP cord-354029-mp5r82g4 565 24 of of IN cord-354029-mp5r82g4 565 25 the the DT cord-354029-mp5r82g4 565 26 dengue dengue NN cord-354029-mp5r82g4 565 27 virus virus NN cord-354029-mp5r82g4 565 28 envelope envelope NN cord-354029-mp5r82g4 565 29 protein protein NN cord-354029-mp5r82g4 565 30 after after IN cord-354029-mp5r82g4 565 31 membrane membrane NN cord-354029-mp5r82g4 565 32 fusion fusion NN cord-354029-mp5r82g4 565 33 Retroviral Retroviral NNP cord-354029-mp5r82g4 565 34 entry entry NN cord-354029-mp5r82g4 565 35 mediated mediate VBN cord-354029-mp5r82g4 565 36 by by IN cord-354029-mp5r82g4 565 37 receptor receptor NN cord-354029-mp5r82g4 565 38 priming priming NN cord-354029-mp5r82g4 565 39 and and CC cord-354029-mp5r82g4 565 40 low low JJ cord-354029-mp5r82g4 565 41 pH ph NN cord-354029-mp5r82g4 565 42 triggering trigger VBG cord-354029-mp5r82g4 565 43 of of IN cord-354029-mp5r82g4 565 44 an an DT cord-354029-mp5r82g4 565 45 envelope envelope NN cord-354029-mp5r82g4 565 46 glycoprotein glycoprotein NN cord-354029-mp5r82g4 565 47 Dilation dilation NN cord-354029-mp5r82g4 565 48 of of IN cord-354029-mp5r82g4 565 49 the the DT cord-354029-mp5r82g4 565 50 human human JJ cord-354029-mp5r82g4 565 51 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 565 52 virus-1 virus-1 NNP cord-354029-mp5r82g4 565 53 envelope envelope NN cord-354029-mp5r82g4 565 54 glycoprotein glycoprotein NN cord-354029-mp5r82g4 565 55 fusion fusion NN cord-354029-mp5r82g4 565 56 pore pore NN cord-354029-mp5r82g4 565 57 revealed reveal VBN cord-354029-mp5r82g4 565 58 by by IN cord-354029-mp5r82g4 565 59 the the DT cord-354029-mp5r82g4 565 60 inhibitory inhibitory JJ cord-354029-mp5r82g4 565 61 action action NN cord-354029-mp5r82g4 565 62 of of IN cord-354029-mp5r82g4 565 63 a a DT cord-354029-mp5r82g4 565 64 synthetic synthetic JJ cord-354029-mp5r82g4 565 65 peptide peptide NN cord-354029-mp5r82g4 565 66 from from IN cord-354029-mp5r82g4 565 67 gp41 gp41 NNP cord-354029-mp5r82g4 565 68 Role role NN cord-354029-mp5r82g4 565 69 of of IN cord-354029-mp5r82g4 565 70 the the DT cord-354029-mp5r82g4 565 71 membrane membrane NN cord-354029-mp5r82g4 565 72 - - HYPH cord-354029-mp5r82g4 565 73 proximal proximal JJ cord-354029-mp5r82g4 565 74 domain domain NN cord-354029-mp5r82g4 565 75 in in IN cord-354029-mp5r82g4 565 76 the the DT cord-354029-mp5r82g4 565 77 initial initial JJ cord-354029-mp5r82g4 565 78 stages stage NNS cord-354029-mp5r82g4 565 79 of of IN cord-354029-mp5r82g4 565 80 human human JJ cord-354029-mp5r82g4 565 81 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 565 82 virus virus NN cord-354029-mp5r82g4 565 83 type type NN cord-354029-mp5r82g4 565 84 1 1 CD cord-354029-mp5r82g4 565 85 envelope envelope NN cord-354029-mp5r82g4 565 86 glycoprotein glycoprotein NN cord-354029-mp5r82g4 565 87 - - HYPH cord-354029-mp5r82g4 565 88 mediated mediate VBN cord-354029-mp5r82g4 565 89 membrane membrane NN cord-354029-mp5r82g4 565 90 fusion fusion NN cord-354029-mp5r82g4 565 91 Fusion Fusion NNP cord-354029-mp5r82g4 565 92 of of IN cord-354029-mp5r82g4 565 93 enveloped envelop VBN cord-354029-mp5r82g4 565 94 viruses virus NNS cord-354029-mp5r82g4 565 95 with with IN cord-354029-mp5r82g4 565 96 cells cell NNS cord-354029-mp5r82g4 565 97 and and CC cord-354029-mp5r82g4 565 98 liposomes liposome NNS cord-354029-mp5r82g4 565 99 . . . cord-354029-mp5r82g4 566 1 Activity activity NN cord-354029-mp5r82g4 566 2 and and CC cord-354029-mp5r82g4 566 3 inactivation inactivation NN cord-354029-mp5r82g4 566 4 Fusogenic Fusogenic NNP cord-354029-mp5r82g4 566 5 mechanisms mechanism NNS cord-354029-mp5r82g4 566 6 of of IN cord-354029-mp5r82g4 566 7 enveloped envelop VBN cord-354029-mp5r82g4 566 8 - - HYPH cord-354029-mp5r82g4 566 9 virus virus NN cord-354029-mp5r82g4 566 10 glycoproteins glycoprotein NNS cord-354029-mp5r82g4 566 11 analyzed analyze VBN cord-354029-mp5r82g4 566 12 by by IN cord-354029-mp5r82g4 566 13 a a DT cord-354029-mp5r82g4 566 14 novel novel JJ cord-354029-mp5r82g4 566 15 recombinant recombinant JJ cord-354029-mp5r82g4 566 16 vaccinia vaccinia NN cord-354029-mp5r82g4 566 17 virusbased virusbase VBN cord-354029-mp5r82g4 566 18 assay assay NN cord-354029-mp5r82g4 566 19 quantitating quantitate VBG cord-354029-mp5r82g4 566 20 cell cell NN cord-354029-mp5r82g4 566 21 fusion fusion NN cord-354029-mp5r82g4 566 22 - - HYPH cord-354029-mp5r82g4 566 23 dependent dependent JJ cord-354029-mp5r82g4 566 24 reporter reporter NN cord-354029-mp5r82g4 566 25 gene gene NN cord-354029-mp5r82g4 566 26 activation activation NN cord-354029-mp5r82g4 566 27 Tight tight JJ cord-354029-mp5r82g4 566 28 binding binding NN cord-354029-mp5r82g4 566 29 of of IN cord-354029-mp5r82g4 566 30 influenza influenza NN cord-354029-mp5r82g4 566 31 virus virus NN cord-354029-mp5r82g4 566 32 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 566 33 to to IN cord-354029-mp5r82g4 566 34 its -PRON- PRP$ cord-354029-mp5r82g4 566 35 receptor receptor NN cord-354029-mp5r82g4 566 36 interferes interfere VBZ cord-354029-mp5r82g4 566 37 with with IN cord-354029-mp5r82g4 566 38 fusion fusion NN cord-354029-mp5r82g4 566 39 pore pore NN cord-354029-mp5r82g4 566 40 dilation dilation NN cord-354029-mp5r82g4 566 41 Mutations Mutations NNPS cord-354029-mp5r82g4 566 42 in in IN cord-354029-mp5r82g4 566 43 the the DT cord-354029-mp5r82g4 566 44 membrane membrane NN cord-354029-mp5r82g4 566 45 - - HYPH cord-354029-mp5r82g4 566 46 spanning span VBG cord-354029-mp5r82g4 566 47 domain domain NN cord-354029-mp5r82g4 566 48 of of IN cord-354029-mp5r82g4 566 49 the the DT cord-354029-mp5r82g4 566 50 human human JJ cord-354029-mp5r82g4 566 51 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 566 52 virus virus NN cord-354029-mp5r82g4 566 53 envelope envelope NN cord-354029-mp5r82g4 566 54 glycoprotein glycoprotein NN cord-354029-mp5r82g4 566 55 that that WDT cord-354029-mp5r82g4 566 56 affect affect VBP cord-354029-mp5r82g4 566 57 fusion fusion NN cord-354029-mp5r82g4 566 58 activity activity NN cord-354029-mp5r82g4 566 59 Leash leash NN cord-354029-mp5r82g4 566 60 in in IN cord-354029-mp5r82g4 566 61 the the DT cord-354029-mp5r82g4 566 62 groove groove NN cord-354029-mp5r82g4 566 63 mechanism mechanism NN cord-354029-mp5r82g4 566 64 of of IN cord-354029-mp5r82g4 566 65 membrane membrane NN cord-354029-mp5r82g4 566 66 fusion fusion NN cord-354029-mp5r82g4 566 67 Fusion Fusion NNP cord-354029-mp5r82g4 566 68 protein protein NN cord-354029-mp5r82g4 566 69 of of IN cord-354029-mp5r82g4 566 70 the the DT cord-354029-mp5r82g4 566 71 paramyxovirus paramyxovirus JJ cord-354029-mp5r82g4 566 72 SV5 SV5 NNP cord-354029-mp5r82g4 566 73 : : : cord-354029-mp5r82g4 566 74 destabilizing destabilize VBG cord-354029-mp5r82g4 566 75 and and CC cord-354029-mp5r82g4 566 76 stabilizing stabilize VBG cord-354029-mp5r82g4 566 77 mutants mutant NNS cord-354029-mp5r82g4 566 78 of of IN cord-354029-mp5r82g4 566 79 fusion fusion NN cord-354029-mp5r82g4 566 80 activation activation NN cord-354029-mp5r82g4 566 81 Insider insider NN cord-354029-mp5r82g4 566 82 information information NN cord-354029-mp5r82g4 566 83 : : : cord-354029-mp5r82g4 566 84 what what WP cord-354029-mp5r82g4 566 85 viruses virus NNS cord-354029-mp5r82g4 566 86 tell tell VBP cord-354029-mp5r82g4 566 87 us -PRON- PRP cord-354029-mp5r82g4 566 88 about about IN cord-354029-mp5r82g4 566 89 endocytosis endocytosis NN cord-354029-mp5r82g4 566 90 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 566 91 entry entry NN cord-354029-mp5r82g4 566 92 into into IN cord-354029-mp5r82g4 566 93 Tcells Tcells NNP cord-354029-mp5r82g4 566 94 is be VBZ cord-354029-mp5r82g4 566 95 not not RB cord-354029-mp5r82g4 566 96 dependent dependent JJ cord-354029-mp5r82g4 566 97 on on IN cord-354029-mp5r82g4 566 98 CD4 CD4 NNP cord-354029-mp5r82g4 566 99 and and CC cord-354029-mp5r82g4 566 100 CCR5 CCR5 NNP cord-354029-mp5r82g4 566 101 localization localization NN cord-354029-mp5r82g4 566 102 to to IN cord-354029-mp5r82g4 566 103 sphingolipid sphingolipid NN cord-354029-mp5r82g4 566 104 - - HYPH cord-354029-mp5r82g4 566 105 enriched enrich VBN cord-354029-mp5r82g4 566 106 , , , cord-354029-mp5r82g4 566 107 detergent detergent NN cord-354029-mp5r82g4 566 108 - - HYPH cord-354029-mp5r82g4 566 109 resistant resistant JJ cord-354029-mp5r82g4 566 110 , , , cord-354029-mp5r82g4 566 111 raft raft NN cord-354029-mp5r82g4 566 112 membrane membrane NN cord-354029-mp5r82g4 566 113 domains domain NNS cord-354029-mp5r82g4 566 114 Liposome liposome NN cord-354029-mp5r82g4 566 115 destabilization destabilization NN cord-354029-mp5r82g4 566 116 induced induce VBN cord-354029-mp5r82g4 566 117 by by IN cord-354029-mp5r82g4 566 118 the the DT cord-354029-mp5r82g4 566 119 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 566 120 fusion fusion NN cord-354029-mp5r82g4 566 121 peptide peptide NN cord-354029-mp5r82g4 566 122 effect effect NN cord-354029-mp5r82g4 566 123 of of IN cord-354029-mp5r82g4 566 124 a a DT cord-354029-mp5r82g4 566 125 single single JJ cord-354029-mp5r82g4 566 126 amino amino NN cord-354029-mp5r82g4 566 127 acid acid NN cord-354029-mp5r82g4 566 128 substitution substitution NN cord-354029-mp5r82g4 566 129 An an DT cord-354029-mp5r82g4 566 130 evolutionarily evolutionarily RB cord-354029-mp5r82g4 566 131 conserved conserve VBN cord-354029-mp5r82g4 566 132 positively positively RB cord-354029-mp5r82g4 566 133 charged charge VBN cord-354029-mp5r82g4 566 134 amino amino NN cord-354029-mp5r82g4 566 135 acid acid NN cord-354029-mp5r82g4 566 136 in in IN cord-354029-mp5r82g4 566 137 the the DT cord-354029-mp5r82g4 566 138 putative putative JJ cord-354029-mp5r82g4 566 139 membrane membrane NN cord-354029-mp5r82g4 566 140 - - HYPH cord-354029-mp5r82g4 566 141 spanning span VBG cord-354029-mp5r82g4 566 142 domain domain NN cord-354029-mp5r82g4 566 143 of of IN cord-354029-mp5r82g4 566 144 the the DT cord-354029-mp5r82g4 566 145 foamy foamy JJ cord-354029-mp5r82g4 566 146 virus virus NN cord-354029-mp5r82g4 566 147 envelope envelope NN cord-354029-mp5r82g4 566 148 protein protein NN cord-354029-mp5r82g4 566 149 controls control VBZ cord-354029-mp5r82g4 566 150 fusion fusion NN cord-354029-mp5r82g4 566 151 activity activity NN cord-354029-mp5r82g4 566 152 Mutational Mutational NNP cord-354029-mp5r82g4 566 153 analysis analysis NN cord-354029-mp5r82g4 566 154 of of IN cord-354029-mp5r82g4 566 155 conserved conserved JJ cord-354029-mp5r82g4 566 156 domains domain NNS cord-354029-mp5r82g4 566 157 within within IN cord-354029-mp5r82g4 566 158 the the DT cord-354029-mp5r82g4 566 159 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 566 160 tail tail NN cord-354029-mp5r82g4 566 161 of of IN cord-354029-mp5r82g4 566 162 gp41 gp41 NNP cord-354029-mp5r82g4 566 163 from from IN cord-354029-mp5r82g4 566 164 human human JJ cord-354029-mp5r82g4 566 165 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 566 166 virus virus NN cord-354029-mp5r82g4 566 167 type type NN cord-354029-mp5r82g4 566 168 1 1 CD cord-354029-mp5r82g4 566 169 : : : cord-354029-mp5r82g4 566 170 effects effect NNS cord-354029-mp5r82g4 566 171 on on IN cord-354029-mp5r82g4 566 172 glycoprotein glycoprotein NN cord-354029-mp5r82g4 566 173 incorporation incorporation NN cord-354029-mp5r82g4 566 174 and and CC cord-354029-mp5r82g4 566 175 infectivity infectivity NN cord-354029-mp5r82g4 566 176 Localization Localization NNP cord-354029-mp5r82g4 566 177 of of IN cord-354029-mp5r82g4 566 178 the the DT cord-354029-mp5r82g4 566 179 labile labile JJ cord-354029-mp5r82g4 566 180 disulfide disulfide NN cord-354029-mp5r82g4 566 181 bond bond NN cord-354029-mp5r82g4 566 182 between between IN cord-354029-mp5r82g4 566 183 SU SU NNP cord-354029-mp5r82g4 566 184 and and CC cord-354029-mp5r82g4 566 185 TM TM NNP cord-354029-mp5r82g4 566 186 of of IN cord-354029-mp5r82g4 566 187 the the DT cord-354029-mp5r82g4 566 188 murine murine JJ cord-354029-mp5r82g4 566 189 leukemia leukemia NN cord-354029-mp5r82g4 566 190 virus virus NN cord-354029-mp5r82g4 566 191 envelope envelope NN cord-354029-mp5r82g4 566 192 protein protein NN cord-354029-mp5r82g4 566 193 complex complex JJ cord-354029-mp5r82g4 566 194 to to IN cord-354029-mp5r82g4 566 195 a a DT cord-354029-mp5r82g4 566 196 highly highly RB cord-354029-mp5r82g4 566 197 conserved conserved JJ cord-354029-mp5r82g4 566 198 CWLC cwlc NN cord-354029-mp5r82g4 566 199 motif motif NN cord-354029-mp5r82g4 566 200 in in IN cord-354029-mp5r82g4 566 201 SU SU NNP cord-354029-mp5r82g4 566 202 that that WDT cord-354029-mp5r82g4 566 203 resembles resemble VBZ cord-354029-mp5r82g4 566 204 the the DT cord-354029-mp5r82g4 566 205 active active JJ cord-354029-mp5r82g4 566 206 - - HYPH cord-354029-mp5r82g4 566 207 site site NN cord-354029-mp5r82g4 566 208 sequence sequence NN cord-354029-mp5r82g4 566 209 of of IN cord-354029-mp5r82g4 566 210 thiol thiol NN cord-354029-mp5r82g4 566 211 - - HYPH cord-354029-mp5r82g4 566 212 disulfide disulfide NN cord-354029-mp5r82g4 566 213 exchange exchange NN cord-354029-mp5r82g4 566 214 enzymes enzyme NNS cord-354029-mp5r82g4 566 215 Human human JJ cord-354029-mp5r82g4 566 216 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 566 217 virus virus NN cord-354029-mp5r82g4 566 218 type type NN cord-354029-mp5r82g4 566 219 1 1 CD cord-354029-mp5r82g4 566 220 uses use VBZ cord-354029-mp5r82g4 566 221 lipid lipid VBG cord-354029-mp5r82g4 566 222 raft raft NN cord-354029-mp5r82g4 566 223 - - HYPH cord-354029-mp5r82g4 566 224 colocalized colocalize VBN cord-354029-mp5r82g4 566 225 CD4 CD4 NNP cord-354029-mp5r82g4 566 226 and and CC cord-354029-mp5r82g4 566 227 chemokine chemokine NN cord-354029-mp5r82g4 566 228 receptors receptor NNS cord-354029-mp5r82g4 566 229 for for IN cord-354029-mp5r82g4 566 230 productive productive JJ cord-354029-mp5r82g4 566 231 entry entry NN cord-354029-mp5r82g4 566 232 into into IN cord-354029-mp5r82g4 566 233 CD4(+ CD4(+ NNP cord-354029-mp5r82g4 566 234 ) ) -RRB- cord-354029-mp5r82g4 567 1 T T NNP cord-354029-mp5r82g4 567 2 cells cell NNS cord-354029-mp5r82g4 567 3 Activation activation NN cord-354029-mp5r82g4 567 4 of of IN cord-354029-mp5r82g4 567 5 vesicular vesicular JJ cord-354029-mp5r82g4 567 6 stomatitis stomatitis NN cord-354029-mp5r82g4 567 7 virus virus NN cord-354029-mp5r82g4 567 8 fusion fusion NN cord-354029-mp5r82g4 567 9 with with IN cord-354029-mp5r82g4 567 10 cells cell NNS cord-354029-mp5r82g4 567 11 by by IN cord-354029-mp5r82g4 567 12 pretreatment pretreatment NN cord-354029-mp5r82g4 567 13 at at IN cord-354029-mp5r82g4 567 14 low low JJ cord-354029-mp5r82g4 567 15 pH pH NNP cord-354029-mp5r82g4 567 16 A a DT cord-354029-mp5r82g4 567 17 specific specific JJ cord-354029-mp5r82g4 567 18 point point NN cord-354029-mp5r82g4 567 19 mutant mutant JJ cord-354029-mp5r82g4 567 20 at at IN cord-354029-mp5r82g4 567 21 position position NN cord-354029-mp5r82g4 567 22 1 1 CD cord-354029-mp5r82g4 567 23 of of IN cord-354029-mp5r82g4 567 24 the the DT cord-354029-mp5r82g4 567 25 influenza influenza NN cord-354029-mp5r82g4 567 26 hemagglutinin hemagglutinin NNP cord-354029-mp5r82g4 567 27 fusion fusion NNP cord-354029-mp5r82g4 567 28 peptide peptide NN cord-354029-mp5r82g4 567 29 displays display VBZ cord-354029-mp5r82g4 567 30 a a DT cord-354029-mp5r82g4 567 31 hemifusion hemifusion NN cord-354029-mp5r82g4 567 32 phenotype phenotype NN cord-354029-mp5r82g4 567 33 Specific specific JJ cord-354029-mp5r82g4 567 34 single single JJ cord-354029-mp5r82g4 567 35 or or CC cord-354029-mp5r82g4 567 36 double double JJ cord-354029-mp5r82g4 567 37 proline proline NN cord-354029-mp5r82g4 567 38 substitutions substitution NNS cord-354029-mp5r82g4 567 39 in in IN cord-354029-mp5r82g4 567 40 the the DT cord-354029-mp5r82g4 567 41 " " `` cord-354029-mp5r82g4 567 42 spring spring NN cord-354029-mp5r82g4 567 43 - - HYPH cord-354029-mp5r82g4 567 44 loaded load VBN cord-354029-mp5r82g4 567 45 " " `` cord-354029-mp5r82g4 567 46 coiled coiled JJ cord-354029-mp5r82g4 567 47 - - HYPH cord-354029-mp5r82g4 567 48 coil coil NN cord-354029-mp5r82g4 567 49 region region NN cord-354029-mp5r82g4 567 50 of of IN cord-354029-mp5r82g4 567 51 the the DT cord-354029-mp5r82g4 567 52 influenza influenza NN cord-354029-mp5r82g4 567 53 hemagglutinin hemagglutinin NNS cord-354029-mp5r82g4 567 54 impair impair VB cord-354029-mp5r82g4 567 55 or or CC cord-354029-mp5r82g4 567 56 abolish abolish VB cord-354029-mp5r82g4 567 57 membrane membrane NN cord-354029-mp5r82g4 567 58 fusion fusion NN cord-354029-mp5r82g4 567 59 activity activity NN cord-354029-mp5r82g4 567 60 pH ph NN cord-354029-mp5r82g4 567 61 - - HYPH cord-354029-mp5r82g4 567 62 independent independent JJ cord-354029-mp5r82g4 567 63 murine murine JJ cord-354029-mp5r82g4 567 64 leukemia leukemia NN cord-354029-mp5r82g4 567 65 virus virus NN cord-354029-mp5r82g4 567 66 ecotropic ecotropic NNP cord-354029-mp5r82g4 567 67 envelope envelope NN cord-354029-mp5r82g4 567 68 - - HYPH cord-354029-mp5r82g4 567 69 mediated mediate VBN cord-354029-mp5r82g4 567 70 cell cell NN cord-354029-mp5r82g4 567 71 fusion fusion NN cord-354029-mp5r82g4 567 72 : : : cord-354029-mp5r82g4 568 1 implications implication NNS cord-354029-mp5r82g4 568 2 for for IN cord-354029-mp5r82g4 568 3 the the DT cord-354029-mp5r82g4 568 4 role role NN cord-354029-mp5r82g4 568 5 of of IN cord-354029-mp5r82g4 568 6 the the DT cord-354029-mp5r82g4 568 7 R R NNP cord-354029-mp5r82g4 568 8 peptide peptide NN cord-354029-mp5r82g4 568 9 and and CC cord-354029-mp5r82g4 568 10 p12E p12e NN cord-354029-mp5r82g4 568 11 TM TM NNP cord-354029-mp5r82g4 568 12 in in IN cord-354029-mp5r82g4 568 13 viral viral JJ cord-354029-mp5r82g4 568 14 entry entry NN cord-354029-mp5r82g4 568 15 Sensitivity sensitivity NN cord-354029-mp5r82g4 568 16 of of IN cord-354029-mp5r82g4 568 17 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 568 18 to to TO cord-354029-mp5r82g4 568 19 entry entry NN cord-354029-mp5r82g4 568 20 inhibitors inhibitor NNS cord-354029-mp5r82g4 568 21 correlates correlate VBZ cord-354029-mp5r82g4 568 22 with with IN cord-354029-mp5r82g4 568 23 envelope envelope NN cord-354029-mp5r82g4 568 24 / / SYM cord-354029-mp5r82g4 568 25 coreceptor coreceptor NN cord-354029-mp5r82g4 568 26 affinity affinity NN cord-354029-mp5r82g4 568 27 , , , cord-354029-mp5r82g4 568 28 receptor receptor NN cord-354029-mp5r82g4 568 29 density density NN cord-354029-mp5r82g4 568 30 , , , cord-354029-mp5r82g4 568 31 and and CC cord-354029-mp5r82g4 568 32 fusion fusion NN cord-354029-mp5r82g4 568 33 kinetics kinetics NNP cord-354029-mp5r82g4 568 34 Function function NN cord-354029-mp5r82g4 568 35 of of IN cord-354029-mp5r82g4 568 36 the the DT cord-354029-mp5r82g4 568 37 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 568 38 domain domain NN cord-354029-mp5r82g4 568 39 of of IN cord-354029-mp5r82g4 568 40 a a DT cord-354029-mp5r82g4 568 41 retroviral retroviral JJ cord-354029-mp5r82g4 568 42 transmembrane transmembrane NN cord-354029-mp5r82g4 568 43 protein protein NN cord-354029-mp5r82g4 568 44 : : : cord-354029-mp5r82g4 569 1 p15E p15E NNP cord-354029-mp5r82g4 569 2 - - HYPH cord-354029-mp5r82g4 569 3 p2E p2E NNS cord-354029-mp5r82g4 569 4 cleavage cleavage NN cord-354029-mp5r82g4 569 5 activates activate VBZ cord-354029-mp5r82g4 569 6 the the DT cord-354029-mp5r82g4 569 7 membrane membrane NN cord-354029-mp5r82g4 569 8 fusion fusion NN cord-354029-mp5r82g4 569 9 capability capability NN cord-354029-mp5r82g4 569 10 of of IN cord-354029-mp5r82g4 569 11 the the DT cord-354029-mp5r82g4 569 12 murine murine JJ cord-354029-mp5r82g4 569 13 leukemia leukemia NN cord-354029-mp5r82g4 569 14 virus virus NN cord-354029-mp5r82g4 569 15 Env env NN cord-354029-mp5r82g4 569 16 protein protein NN cord-354029-mp5r82g4 569 17 The the DT cord-354029-mp5r82g4 569 18 envelope envelope NN cord-354029-mp5r82g4 569 19 glycoprotein glycoprotein NN cord-354029-mp5r82g4 569 20 from from IN cord-354029-mp5r82g4 569 21 tick tick NN cord-354029-mp5r82g4 569 22 - - HYPH cord-354029-mp5r82g4 569 23 borne bear VBN cord-354029-mp5r82g4 569 24 encephalitis encephalitis JJ cord-354029-mp5r82g4 569 25 virus virus NN cord-354029-mp5r82g4 569 26 at at IN cord-354029-mp5r82g4 569 27 2 2 CD cord-354029-mp5r82g4 569 28 resolution resolution NN cord-354029-mp5r82g4 569 29 Palmitoylation Palmitoylation NNP cord-354029-mp5r82g4 569 30 of of IN cord-354029-mp5r82g4 569 31 the the DT cord-354029-mp5r82g4 569 32 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 569 33 envelope envelope NN cord-354029-mp5r82g4 569 34 glycoprotein glycoprotein NN cord-354029-mp5r82g4 569 35 is be VBZ cord-354029-mp5r82g4 569 36 critical critical JJ cord-354029-mp5r82g4 569 37 for for IN cord-354029-mp5r82g4 569 38 viral viral JJ cord-354029-mp5r82g4 569 39 infectivity infectivity NN cord-354029-mp5r82g4 569 40 Membrane membrane NN cord-354029-mp5r82g4 569 41 fusion fusion NN cord-354029-mp5r82g4 569 42 machines machine NNS cord-354029-mp5r82g4 569 43 of of IN cord-354029-mp5r82g4 569 44 paramyxoviruses paramyxovirus NNS cord-354029-mp5r82g4 569 45 : : : cord-354029-mp5r82g4 569 46 capture capture NN cord-354029-mp5r82g4 569 47 of of IN cord-354029-mp5r82g4 569 48 intermediates intermediate NNS cord-354029-mp5r82g4 569 49 of of IN cord-354029-mp5r82g4 569 50 fusion fusion NN cord-354029-mp5r82g4 569 51 Pre pre NN cord-354029-mp5r82g4 569 52 - - JJ cord-354029-mp5r82g4 569 53 transmembrane transmembrane JJ cord-354029-mp5r82g4 569 54 sequence sequence NN cord-354029-mp5r82g4 569 55 of of IN cord-354029-mp5r82g4 569 56 Ebola Ebola NNP cord-354029-mp5r82g4 569 57 glycoprotein glycoprotein NN cord-354029-mp5r82g4 569 58 . . . cord-354029-mp5r82g4 570 1 Interfacial interfacial JJ cord-354029-mp5r82g4 570 2 hydrophobicity hydrophobicity NN cord-354029-mp5r82g4 570 3 distribution distribution NN cord-354029-mp5r82g4 570 4 and and CC cord-354029-mp5r82g4 570 5 interaction interaction NN cord-354029-mp5r82g4 570 6 with with IN cord-354029-mp5r82g4 570 7 membranes membrane NNS cord-354029-mp5r82g4 570 8 Sphingomyelin Sphingomyelin NNP cord-354029-mp5r82g4 570 9 and and CC cord-354029-mp5r82g4 570 10 cholesterol cholesterol NN cord-354029-mp5r82g4 570 11 promote promote VBP cord-354029-mp5r82g4 570 12 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 570 13 gp41 gp41 NNP cord-354029-mp5r82g4 570 14 pretransmembrane pretransmembrane NNP cord-354029-mp5r82g4 570 15 sequence sequence NN cord-354029-mp5r82g4 570 16 surface surface NN cord-354029-mp5r82g4 570 17 aggregation aggregation NN cord-354029-mp5r82g4 570 18 and and CC cord-354029-mp5r82g4 570 19 membrane membrane NN cord-354029-mp5r82g4 570 20 restructuring restructure VBG cord-354029-mp5r82g4 570 21 Fatty fatty JJ cord-354029-mp5r82g4 570 22 acids acid NNS cord-354029-mp5r82g4 570 23 on on IN cord-354029-mp5r82g4 570 24 the the DT cord-354029-mp5r82g4 570 25 A A NNP cord-354029-mp5r82g4 570 26 / / SYM cord-354029-mp5r82g4 570 27 USSR/77 ussr/77 JJ cord-354029-mp5r82g4 570 28 influenza influenza NN cord-354029-mp5r82g4 570 29 virus virus NN cord-354029-mp5r82g4 570 30 hemagglutinin hemagglutinin NNS cord-354029-mp5r82g4 570 31 facilitate facilitate VBP cord-354029-mp5r82g4 570 32 the the DT cord-354029-mp5r82g4 570 33 transition transition NN cord-354029-mp5r82g4 570 34 from from IN cord-354029-mp5r82g4 570 35 hemifusion hemifusion NN cord-354029-mp5r82g4 570 36 to to IN cord-354029-mp5r82g4 571 1 fusion fusion NN cord-354029-mp5r82g4 571 2 pore pore NN cord-354029-mp5r82g4 571 3 formation formation NN cord-354029-mp5r82g4 571 4 A a DT cord-354029-mp5r82g4 571 5 conserved conserved JJ cord-354029-mp5r82g4 571 6 tryptophan tryptophan NN cord-354029-mp5r82g4 571 7 - - HYPH cord-354029-mp5r82g4 571 8 rich rich JJ cord-354029-mp5r82g4 571 9 motif motif NN cord-354029-mp5r82g4 571 10 in in IN cord-354029-mp5r82g4 571 11 the the DT cord-354029-mp5r82g4 571 12 membrane membrane NN cord-354029-mp5r82g4 571 13 - - HYPH cord-354029-mp5r82g4 571 14 proximal proximal VBG cord-354029-mp5r82g4 571 15 region region NN cord-354029-mp5r82g4 571 16 of of IN cord-354029-mp5r82g4 571 17 the the DT cord-354029-mp5r82g4 571 18 human human JJ cord-354029-mp5r82g4 571 19 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 571 20 virus virus NN cord-354029-mp5r82g4 571 21 type type NN cord-354029-mp5r82g4 572 1 1 1 LS cord-354029-mp5r82g4 572 2 gp41 gp41 NNP cord-354029-mp5r82g4 572 3 ectodomain ectodomain NNP cord-354029-mp5r82g4 572 4 is be VBZ cord-354029-mp5r82g4 572 5 important important JJ cord-354029-mp5r82g4 572 6 for for IN cord-354029-mp5r82g4 572 7 Env env NN cord-354029-mp5r82g4 572 8 - - HYPH cord-354029-mp5r82g4 572 9 mediated mediate VBN cord-354029-mp5r82g4 572 10 fusion fusion NN cord-354029-mp5r82g4 572 11 and and CC cord-354029-mp5r82g4 572 12 virus virus NN cord-354029-mp5r82g4 572 13 infectivity infectivity NN cord-354029-mp5r82g4 573 1 The the DT cord-354029-mp5r82g4 573 2 membrane membrane NN cord-354029-mp5r82g4 573 3 - - HYPH cord-354029-mp5r82g4 573 4 proximal proximal JJ cord-354029-mp5r82g4 573 5 tryptophanrich tryptophanrich NNP cord-354029-mp5r82g4 573 6 region region NN cord-354029-mp5r82g4 573 7 of of IN cord-354029-mp5r82g4 573 8 the the DT cord-354029-mp5r82g4 573 9 HIV HIV NNP cord-354029-mp5r82g4 573 10 glycoprotein glycoprotein NN cord-354029-mp5r82g4 573 11 , , , cord-354029-mp5r82g4 573 12 gp41 gp41 NNP cord-354029-mp5r82g4 573 13 , , , cord-354029-mp5r82g4 573 14 forms form VBZ cord-354029-mp5r82g4 573 15 a a DT cord-354029-mp5r82g4 573 16 well well RB cord-354029-mp5r82g4 573 17 - - HYPH cord-354029-mp5r82g4 573 18 defined define VBN cord-354029-mp5r82g4 573 19 helix helix NN cord-354029-mp5r82g4 573 20 in in IN cord-354029-mp5r82g4 573 21 dodecylphosphocholine dodecylphosphocholine NN cord-354029-mp5r82g4 573 22 micelles micelle NNS cord-354029-mp5r82g4 573 23 Antibodies antibody NNS cord-354029-mp5r82g4 573 24 to to IN cord-354029-mp5r82g4 573 25 CD9 CD9 NNP cord-354029-mp5r82g4 573 26 , , , cord-354029-mp5r82g4 573 27 a a DT cord-354029-mp5r82g4 573 28 tetraspan tetraspan NNP cord-354029-mp5r82g4 573 29 transmembrane transmembrane NNP cord-354029-mp5r82g4 573 30 protein protein NN cord-354029-mp5r82g4 573 31 , , , cord-354029-mp5r82g4 573 32 inhibit inhibit VBP cord-354029-mp5r82g4 573 33 canine canine JJ cord-354029-mp5r82g4 573 34 distemper distemper NN cord-354029-mp5r82g4 573 35 virus virus NN cord-354029-mp5r82g4 573 36 - - HYPH cord-354029-mp5r82g4 573 37 induced induce VBN cord-354029-mp5r82g4 573 38 cell cell NN cord-354029-mp5r82g4 573 39 - - HYPH cord-354029-mp5r82g4 573 40 cell cell NN cord-354029-mp5r82g4 573 41 fusion fusion NN cord-354029-mp5r82g4 573 42 but but CC cord-354029-mp5r82g4 573 43 not not RB cord-354029-mp5r82g4 573 44 virus virus NN cord-354029-mp5r82g4 573 45 - - HYPH cord-354029-mp5r82g4 573 46 cell cell NN cord-354029-mp5r82g4 573 47 fusion fusion NN cord-354029-mp5r82g4 573 48 Role role NN cord-354029-mp5r82g4 573 49 of of IN cord-354029-mp5r82g4 573 50 the the DT cord-354029-mp5r82g4 573 51 fusion fusion NN cord-354029-mp5r82g4 573 52 peptide peptide NN cord-354029-mp5r82g4 573 53 sequence sequence NN cord-354029-mp5r82g4 573 54 in in IN cord-354029-mp5r82g4 573 55 initial initial JJ cord-354029-mp5r82g4 573 56 stages stage NNS cord-354029-mp5r82g4 573 57 of of IN cord-354029-mp5r82g4 573 58 influenza influenza NN cord-354029-mp5r82g4 573 59 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 573 60 - - HYPH cord-354029-mp5r82g4 573 61 induced induce VBN cord-354029-mp5r82g4 573 62 cell cell NN cord-354029-mp5r82g4 573 63 fusion fusion NN cord-354029-mp5r82g4 573 64 Maturation maturation NN cord-354029-mp5r82g4 573 65 of of IN cord-354029-mp5r82g4 573 66 murine murine JJ cord-354029-mp5r82g4 573 67 leukemia leukemia NN cord-354029-mp5r82g4 573 68 virus virus NN cord-354029-mp5r82g4 573 69 Env env NN cord-354029-mp5r82g4 573 70 proteins protein NNS cord-354029-mp5r82g4 573 71 in in IN cord-354029-mp5r82g4 573 72 the the DT cord-354029-mp5r82g4 573 73 absence absence NN cord-354029-mp5r82g4 573 74 of of IN cord-354029-mp5r82g4 573 75 other other JJ cord-354029-mp5r82g4 573 76 viral viral JJ cord-354029-mp5r82g4 573 77 proteins protein NNS cord-354029-mp5r82g4 573 78 Mutations Mutations NNPS cord-354029-mp5r82g4 573 79 in in IN cord-354029-mp5r82g4 573 80 the the DT cord-354029-mp5r82g4 573 81 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 573 82 domain domain NN cord-354029-mp5r82g4 573 83 of of IN cord-354029-mp5r82g4 573 84 a a DT cord-354029-mp5r82g4 573 85 paramyxovirus paramyxovirus JJ cord-354029-mp5r82g4 573 86 fusion fusion NN cord-354029-mp5r82g4 573 87 glycoprotein glycoprotein NN cord-354029-mp5r82g4 573 88 rescue rescue NN cord-354029-mp5r82g4 573 89 syncytium syncytium NN cord-354029-mp5r82g4 573 90 formation formation NN cord-354029-mp5r82g4 573 91 and and CC cord-354029-mp5r82g4 573 92 eliminate eliminate VB cord-354029-mp5r82g4 573 93 the the DT cord-354029-mp5r82g4 573 94 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 573 95 - - HYPH cord-354029-mp5r82g4 573 96 neuraminidase neuraminidase NN cord-354029-mp5r82g4 573 97 protein protein NN cord-354029-mp5r82g4 573 98 requirement requirement NN cord-354029-mp5r82g4 573 99 for for IN cord-354029-mp5r82g4 573 100 membrane membrane NN cord-354029-mp5r82g4 573 101 fusion fusion NN cord-354029-mp5r82g4 573 102 Caveolae Caveolae NNP cord-354029-mp5r82g4 573 103 as as IN cord-354029-mp5r82g4 573 104 portals portal NNS cord-354029-mp5r82g4 573 105 of of IN cord-354029-mp5r82g4 573 106 entry entry NN cord-354029-mp5r82g4 573 107 for for IN cord-354029-mp5r82g4 573 108 microbes microbe NNS cord-354029-mp5r82g4 574 1 Interactions interaction NNS cord-354029-mp5r82g4 574 2 between between IN cord-354029-mp5r82g4 574 3 the the DT cord-354029-mp5r82g4 574 4 transmembrane transmembrane NN cord-354029-mp5r82g4 574 5 segments segment NNS cord-354029-mp5r82g4 574 6 of of IN cord-354029-mp5r82g4 574 7 the the DT cord-354029-mp5r82g4 574 8 alphavirus alphavirus NNP cord-354029-mp5r82g4 574 9 E1 E1 NNP cord-354029-mp5r82g4 574 10 and and CC cord-354029-mp5r82g4 574 11 E2 E2 NNP cord-354029-mp5r82g4 574 12 proteins protein NNS cord-354029-mp5r82g4 574 13 play play VBP cord-354029-mp5r82g4 574 14 a a DT cord-354029-mp5r82g4 574 15 role role NN cord-354029-mp5r82g4 574 16 in in IN cord-354029-mp5r82g4 574 17 virus virus NN cord-354029-mp5r82g4 574 18 budding budding NN cord-354029-mp5r82g4 574 19 and and CC cord-354029-mp5r82g4 574 20 fusion fusion NN cord-354029-mp5r82g4 574 21 Influenza Influenza NNP cord-354029-mp5r82g4 574 22 fusion fusion NN cord-354029-mp5r82g4 574 23 peptides peptide NNS cord-354029-mp5r82g4 574 24 Receptor Receptor NNP cord-354029-mp5r82g4 574 25 binding binding NN cord-354029-mp5r82g4 574 26 and and CC cord-354029-mp5r82g4 574 27 membrane membrane NN cord-354029-mp5r82g4 574 28 fusion fusion NN cord-354029-mp5r82g4 574 29 in in IN cord-354029-mp5r82g4 574 30 virus virus NN cord-354029-mp5r82g4 574 31 entry entry NN cord-354029-mp5r82g4 574 32 : : : cord-354029-mp5r82g4 574 33 the the DT cord-354029-mp5r82g4 574 34 influenza influenza NN cord-354029-mp5r82g4 574 35 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 574 36 Inhibition inhibition NN cord-354029-mp5r82g4 574 37 of of IN cord-354029-mp5r82g4 574 38 influenza influenza NN cord-354029-mp5r82g4 574 39 virus virus NN cord-354029-mp5r82g4 574 40 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 574 41 - - HYPH cord-354029-mp5r82g4 574 42 mediated mediate VBN cord-354029-mp5r82g4 574 43 membrane membrane NN cord-354029-mp5r82g4 574 44 fusion fusion NN cord-354029-mp5r82g4 574 45 by by IN cord-354029-mp5r82g4 574 46 a a DT cord-354029-mp5r82g4 574 47 compound compound NN cord-354029-mp5r82g4 574 48 related relate VBN cord-354029-mp5r82g4 574 49 to to IN cord-354029-mp5r82g4 574 50 podocarpic podocarpic JJ cord-354029-mp5r82g4 574 51 acid acid NNP cord-354029-mp5r82g4 574 52 Influenza Influenza NNP cord-354029-mp5r82g4 574 53 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 574 54 - - HYPH cord-354029-mp5r82g4 574 55 mediated mediate VBN cord-354029-mp5r82g4 574 56 membrane membrane NN cord-354029-mp5r82g4 574 57 fusion fusion NN cord-354029-mp5r82g4 574 58 : : : cord-354029-mp5r82g4 574 59 influence influence NN cord-354029-mp5r82g4 574 60 of of IN cord-354029-mp5r82g4 574 61 receptor receptor NN cord-354029-mp5r82g4 574 62 binding bind VBG cord-354029-mp5r82g4 574 63 on on IN cord-354029-mp5r82g4 574 64 the the DT cord-354029-mp5r82g4 574 65 lag lag NN cord-354029-mp5r82g4 574 66 phase phase NN cord-354029-mp5r82g4 574 67 preceding precede VBG cord-354029-mp5r82g4 574 68 fusion fusion NN cord-354029-mp5r82g4 574 69 Effects effect NNS cord-354029-mp5r82g4 574 70 of of IN cord-354029-mp5r82g4 574 71 low low JJ cord-354029-mp5r82g4 574 72 pH ph NN cord-354029-mp5r82g4 574 73 on on IN cord-354029-mp5r82g4 574 74 influenza influenza NN cord-354029-mp5r82g4 574 75 virus virus NN cord-354029-mp5r82g4 574 76 . . . cord-354029-mp5r82g4 575 1 Activation activation NN cord-354029-mp5r82g4 575 2 and and CC cord-354029-mp5r82g4 575 3 inactivation inactivation NN cord-354029-mp5r82g4 575 4 of of IN cord-354029-mp5r82g4 575 5 the the DT cord-354029-mp5r82g4 575 6 membrane membrane NN cord-354029-mp5r82g4 575 7 fusion fusion NN cord-354029-mp5r82g4 575 8 capacity capacity NN cord-354029-mp5r82g4 575 9 of of IN cord-354029-mp5r82g4 575 10 the the DT cord-354029-mp5r82g4 575 11 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 575 12 pH ph NN cord-354029-mp5r82g4 575 13 - - HYPH cord-354029-mp5r82g4 575 14 independent independent JJ cord-354029-mp5r82g4 575 15 HIV HIV NNP cord-354029-mp5r82g4 575 16 entry entry NN cord-354029-mp5r82g4 575 17 into into IN cord-354029-mp5r82g4 575 18 CD4-positive CD4-positive NNP cord-354029-mp5r82g4 575 19 T t NN cord-354029-mp5r82g4 575 20 cells cell NNS cord-354029-mp5r82g4 575 21 via via IN cord-354029-mp5r82g4 575 22 virus virus NN cord-354029-mp5r82g4 575 23 envelope envelope NN cord-354029-mp5r82g4 575 24 fusion fusion NN cord-354029-mp5r82g4 575 25 to to IN cord-354029-mp5r82g4 575 26 the the DT cord-354029-mp5r82g4 575 27 plasma plasma NN cord-354029-mp5r82g4 575 28 membrane membrane NN cord-354029-mp5r82g4 575 29 Role role NN cord-354029-mp5r82g4 575 30 of of IN cord-354029-mp5r82g4 575 31 metastability metastability NN cord-354029-mp5r82g4 575 32 and and CC cord-354029-mp5r82g4 575 33 acidic acidic JJ cord-354029-mp5r82g4 575 34 pH ph NN cord-354029-mp5r82g4 575 35 in in IN cord-354029-mp5r82g4 575 36 membrane membrane NN cord-354029-mp5r82g4 575 37 fusion fusion NN cord-354029-mp5r82g4 575 38 by by IN cord-354029-mp5r82g4 575 39 tick tick NN cord-354029-mp5r82g4 575 40 - - HYPH cord-354029-mp5r82g4 575 41 borne bear VBN cord-354029-mp5r82g4 575 42 encephalitis encephalitis JJ cord-354029-mp5r82g4 575 43 virus virus NN cord-354029-mp5r82g4 575 44 Structural structural JJ cord-354029-mp5r82g4 575 45 requirements requirement NNS cord-354029-mp5r82g4 575 46 for for IN cord-354029-mp5r82g4 575 47 low low JJ cord-354029-mp5r82g4 575 48 - - HYPH cord-354029-mp5r82g4 575 49 pH ph NN cord-354029-mp5r82g4 575 50 - - HYPH cord-354029-mp5r82g4 575 51 induced induce VBN cord-354029-mp5r82g4 575 52 rearrangements rearrangement NNS cord-354029-mp5r82g4 575 53 in in IN cord-354029-mp5r82g4 575 54 the the DT cord-354029-mp5r82g4 575 55 envelope envelope NN cord-354029-mp5r82g4 575 56 glycoprotein glycoprotein NN cord-354029-mp5r82g4 575 57 of of IN cord-354029-mp5r82g4 575 58 tick tick NN cord-354029-mp5r82g4 575 59 - - HYPH cord-354029-mp5r82g4 575 60 borne bear VBN cord-354029-mp5r82g4 575 61 encephalitis encephalitis JJ cord-354029-mp5r82g4 575 62 virus virus NN cord-354029-mp5r82g4 575 63 Membrane membrane NN cord-354029-mp5r82g4 575 64 interactions interaction NNS cord-354029-mp5r82g4 575 65 of of IN cord-354029-mp5r82g4 575 66 the the DT cord-354029-mp5r82g4 575 67 tick tick NN cord-354029-mp5r82g4 575 68 - - HYPH cord-354029-mp5r82g4 575 69 borne bear VBN cord-354029-mp5r82g4 575 70 encephalitis encephalitis JJ cord-354029-mp5r82g4 575 71 virus virus NN cord-354029-mp5r82g4 575 72 fusion fusion NN cord-354029-mp5r82g4 575 73 protein protein NN cord-354029-mp5r82g4 575 74 E e NN cord-354029-mp5r82g4 575 75 at at IN cord-354029-mp5r82g4 575 76 low low JJ cord-354029-mp5r82g4 575 77 pH pH NNP cord-354029-mp5r82g4 575 78 Detection detection NN cord-354029-mp5r82g4 575 79 of of IN cord-354029-mp5r82g4 575 80 an an DT cord-354029-mp5r82g4 575 81 interaction interaction NN cord-354029-mp5r82g4 575 82 between between IN cord-354029-mp5r82g4 575 83 the the DT cord-354029-mp5r82g4 575 84 HN HN NNP cord-354029-mp5r82g4 575 85 and and CC cord-354029-mp5r82g4 575 86 F F NNP cord-354029-mp5r82g4 575 87 proteins protein NNS cord-354029-mp5r82g4 575 88 in in IN cord-354029-mp5r82g4 575 89 Newcastle Newcastle NNP cord-354029-mp5r82g4 575 90 disease disease NN cord-354029-mp5r82g4 575 91 virus virus NN cord-354029-mp5r82g4 575 92 - - HYPH cord-354029-mp5r82g4 575 93 infected infect VBN cord-354029-mp5r82g4 575 94 cells cell NNS cord-354029-mp5r82g4 575 95 Membrane membrane NN cord-354029-mp5r82g4 575 96 interface interface NN cord-354029-mp5r82g4 575 97 - - HYPH cord-354029-mp5r82g4 575 98 interacting interact VBG cord-354029-mp5r82g4 575 99 sequences sequence NNS cord-354029-mp5r82g4 575 100 within within IN cord-354029-mp5r82g4 575 101 the the DT cord-354029-mp5r82g4 575 102 ectodomain ectodomain NN cord-354029-mp5r82g4 575 103 of of IN cord-354029-mp5r82g4 575 104 the the DT cord-354029-mp5r82g4 575 105 human human JJ cord-354029-mp5r82g4 575 106 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 575 107 virus virus NN cord-354029-mp5r82g4 575 108 type type NN cord-354029-mp5r82g4 575 109 1 1 CD cord-354029-mp5r82g4 575 110 envelope envelope NN cord-354029-mp5r82g4 575 111 glycoprotein glycoprotein NN cord-354029-mp5r82g4 575 112 : : : cord-354029-mp5r82g4 575 113 putative putative JJ cord-354029-mp5r82g4 575 114 role role NN cord-354029-mp5r82g4 575 115 during during IN cord-354029-mp5r82g4 575 116 viral viral JJ cord-354029-mp5r82g4 575 117 fusion fusion NN cord-354029-mp5r82g4 575 118 Lipid Lipid NNP cord-354029-mp5r82g4 575 119 rafts raft NNS cord-354029-mp5r82g4 575 120 and and CC cord-354029-mp5r82g4 575 121 assembly assembly NN cord-354029-mp5r82g4 575 122 of of IN cord-354029-mp5r82g4 575 123 enveloped envelop VBN cord-354029-mp5r82g4 575 124 viruses virus NNS cord-354029-mp5r82g4 575 125 Soluble soluble JJ cord-354029-mp5r82g4 575 126 receptor receptor NN cord-354029-mp5r82g4 575 127 potentiates potentiate VBZ cord-354029-mp5r82g4 575 128 receptor receptor NN cord-354029-mp5r82g4 575 129 - - HYPH cord-354029-mp5r82g4 575 130 independent independent JJ cord-354029-mp5r82g4 575 131 infection infection NN cord-354029-mp5r82g4 575 132 by by IN cord-354029-mp5r82g4 575 133 murine murine JJ cord-354029-mp5r82g4 575 134 coronavirus coronavirus NN cord-354029-mp5r82g4 575 135 Role role NN cord-354029-mp5r82g4 575 136 of of IN cord-354029-mp5r82g4 575 137 the the DT cord-354029-mp5r82g4 575 138 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 575 139 - - HYPH cord-354029-mp5r82g4 575 140 neuraminidase neuraminidase NN cord-354029-mp5r82g4 575 141 protein protein NN cord-354029-mp5r82g4 575 142 in in IN cord-354029-mp5r82g4 575 143 the the DT cord-354029-mp5r82g4 575 144 mechanism mechanism NN cord-354029-mp5r82g4 575 145 of of IN cord-354029-mp5r82g4 575 146 paramyxovirus paramyxovirus JJ cord-354029-mp5r82g4 575 147 - - HYPH cord-354029-mp5r82g4 575 148 cell cell NN cord-354029-mp5r82g4 575 149 membrane membrane NN cord-354029-mp5r82g4 575 150 fusion fusion NN cord-354029-mp5r82g4 575 151 Viral viral JJ cord-354029-mp5r82g4 575 152 fusion fusion NN cord-354029-mp5r82g4 575 153 peptides peptide NNS cord-354029-mp5r82g4 575 154 : : : cord-354029-mp5r82g4 575 155 a a DT cord-354029-mp5r82g4 575 156 tool tool NN cord-354029-mp5r82g4 575 157 set set VBN cord-354029-mp5r82g4 575 158 to to TO cord-354029-mp5r82g4 575 159 disrupt disrupt VB cord-354029-mp5r82g4 575 160 and and CC cord-354029-mp5r82g4 575 161 connect connect VB cord-354029-mp5r82g4 575 162 biological biological JJ cord-354029-mp5r82g4 575 163 membranes membrane NNS cord-354029-mp5r82g4 575 164 Structure structure NN cord-354029-mp5r82g4 575 165 and and CC cord-354029-mp5r82g4 575 166 function function NN cord-354029-mp5r82g4 575 167 of of IN cord-354029-mp5r82g4 575 168 membrane membrane NN cord-354029-mp5r82g4 575 169 fusion fusion NN cord-354029-mp5r82g4 575 170 peptides peptide NNS cord-354029-mp5r82g4 576 1 The the DT cord-354029-mp5r82g4 576 2 role role NN cord-354029-mp5r82g4 576 3 of of IN cord-354029-mp5r82g4 576 4 the the DT cord-354029-mp5r82g4 576 5 membrane membrane NN cord-354029-mp5r82g4 576 6 - - HYPH cord-354029-mp5r82g4 576 7 spanning span VBG cord-354029-mp5r82g4 576 8 domain domain NN cord-354029-mp5r82g4 576 9 sequence sequence NN cord-354029-mp5r82g4 576 10 in in IN cord-354029-mp5r82g4 576 11 glycoprotein glycoprotein NN cord-354029-mp5r82g4 576 12 - - HYPH cord-354029-mp5r82g4 576 13 mediated mediate VBN cord-354029-mp5r82g4 576 14 membrane membrane NN cord-354029-mp5r82g4 576 15 fusion fusion NN cord-354029-mp5r82g4 576 16 Oligomerization Oligomerization NNP cord-354029-mp5r82g4 576 17 , , , cord-354029-mp5r82g4 576 18 secretion secretion NN cord-354029-mp5r82g4 576 19 , , , cord-354029-mp5r82g4 576 20 and and CC cord-354029-mp5r82g4 576 21 biological biological JJ cord-354029-mp5r82g4 576 22 function function NN cord-354029-mp5r82g4 576 23 of of IN cord-354029-mp5r82g4 576 24 an an DT cord-354029-mp5r82g4 576 25 anchor anchor NN cord-354029-mp5r82g4 576 26 - - HYPH cord-354029-mp5r82g4 576 27 free free JJ cord-354029-mp5r82g4 576 28 parainfluenza parainfluenza NNP cord-354029-mp5r82g4 576 29 virus virus NN cord-354029-mp5r82g4 576 30 type type NN cord-354029-mp5r82g4 576 31 2 2 CD cord-354029-mp5r82g4 577 1 ( ( -LRB- cord-354029-mp5r82g4 577 2 PI2 PI2 NNP cord-354029-mp5r82g4 577 3 ) ) -RRB- cord-354029-mp5r82g4 577 4 fusion fusion NN cord-354029-mp5r82g4 577 5 protein protein NN cord-354029-mp5r82g4 577 6 Regulation Regulation NNP cord-354029-mp5r82g4 577 7 of of IN cord-354029-mp5r82g4 577 8 fusion fusion NN cord-354029-mp5r82g4 577 9 activity activity NN cord-354029-mp5r82g4 577 10 by by IN cord-354029-mp5r82g4 577 11 the the DT cord-354029-mp5r82g4 577 12 cytoplasmic cytoplasmic JJ cord-354029-mp5r82g4 577 13 domain domain NN cord-354029-mp5r82g4 577 14 of of IN cord-354029-mp5r82g4 577 15 a a DT cord-354029-mp5r82g4 577 16 paramyxovirus paramyxovirus NNP cord-354029-mp5r82g4 577 17 F F NNP cord-354029-mp5r82g4 577 18 protein protein NN cord-354029-mp5r82g4 577 19 A a DT cord-354029-mp5r82g4 577 20 single single JJ cord-354029-mp5r82g4 577 21 point point NN cord-354029-mp5r82g4 577 22 mutation mutation NN cord-354029-mp5r82g4 577 23 controls control VBZ cord-354029-mp5r82g4 577 24 the the DT cord-354029-mp5r82g4 577 25 cholesterol cholesterol NN cord-354029-mp5r82g4 577 26 dependence dependence NN cord-354029-mp5r82g4 577 27 of of IN cord-354029-mp5r82g4 577 28 Semliki Semliki NNP cord-354029-mp5r82g4 577 29 Forest Forest NNP cord-354029-mp5r82g4 577 30 virus virus NN cord-354029-mp5r82g4 577 31 entry entry NN cord-354029-mp5r82g4 577 32 and and CC cord-354029-mp5r82g4 577 33 exit exit NN cord-354029-mp5r82g4 577 34 Role role NN cord-354029-mp5r82g4 577 35 of of IN cord-354029-mp5r82g4 577 36 cholesterol cholesterol NN cord-354029-mp5r82g4 577 37 in in IN cord-354029-mp5r82g4 577 38 human human JJ cord-354029-mp5r82g4 577 39 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 577 40 virus virus NN cord-354029-mp5r82g4 577 41 type type NN cord-354029-mp5r82g4 577 42 1 1 CD cord-354029-mp5r82g4 577 43 envelope envelope NN cord-354029-mp5r82g4 577 44 protein protein NN cord-354029-mp5r82g4 577 45 - - HYPH cord-354029-mp5r82g4 577 46 mediated mediate VBN cord-354029-mp5r82g4 577 47 fusion fusion NN cord-354029-mp5r82g4 577 48 with with IN cord-354029-mp5r82g4 577 49 host host NN cord-354029-mp5r82g4 577 50 cells cell NNS cord-354029-mp5r82g4 577 51 Sphingolipid Sphingolipid NNP cord-354029-mp5r82g4 577 52 and and CC cord-354029-mp5r82g4 577 53 cholesterol cholesterol NN cord-354029-mp5r82g4 577 54 dependence dependence NN cord-354029-mp5r82g4 577 55 of of IN cord-354029-mp5r82g4 577 56 alphavirus alphavirus NNP cord-354029-mp5r82g4 577 57 membrane membrane NN cord-354029-mp5r82g4 577 58 fusion fusion NN cord-354029-mp5r82g4 577 59 . . . cord-354029-mp5r82g4 578 1 Lack lack NN cord-354029-mp5r82g4 578 2 of of IN cord-354029-mp5r82g4 578 3 correlation correlation NN cord-354029-mp5r82g4 578 4 with with IN cord-354029-mp5r82g4 578 5 lipid lipid NN cord-354029-mp5r82g4 578 6 raft raft NN cord-354029-mp5r82g4 578 7 formation formation NN cord-354029-mp5r82g4 578 8 in in IN cord-354029-mp5r82g4 578 9 target target NN cord-354029-mp5r82g4 578 10 liposomes liposome NNS cord-354029-mp5r82g4 578 11 Membrane membrane NN cord-354029-mp5r82g4 578 12 fusion fusion NN cord-354029-mp5r82g4 578 13 of of IN cord-354029-mp5r82g4 578 14 Semliki Semliki NNP cord-354029-mp5r82g4 578 15 Forest Forest NNP cord-354029-mp5r82g4 578 16 virus virus NN cord-354029-mp5r82g4 578 17 involves involve VBZ cord-354029-mp5r82g4 578 18 homotrimers homotrimer NNS cord-354029-mp5r82g4 578 19 of of IN cord-354029-mp5r82g4 578 20 the the DT cord-354029-mp5r82g4 578 21 fusion fusion NN cord-354029-mp5r82g4 578 22 protein protein NN cord-354029-mp5r82g4 578 23 Membrane Membrane NNP cord-354029-mp5r82g4 578 24 fusion fusion NN cord-354029-mp5r82g4 578 25 process process NN cord-354029-mp5r82g4 578 26 of of IN cord-354029-mp5r82g4 578 27 Semliki Semliki NNP cord-354029-mp5r82g4 578 28 Forest Forest NNP cord-354029-mp5r82g4 578 29 virus virus NN cord-354029-mp5r82g4 578 30 . . . cord-354029-mp5r82g4 579 1 I -PRON- PRP cord-354029-mp5r82g4 579 2 : : : cord-354029-mp5r82g4 580 1 Low low JJ cord-354029-mp5r82g4 580 2 pH ph NN cord-354029-mp5r82g4 580 3 - - HYPH cord-354029-mp5r82g4 580 4 induced induce VBN cord-354029-mp5r82g4 580 5 rearrangement rearrangement NN cord-354029-mp5r82g4 580 6 in in IN cord-354029-mp5r82g4 580 7 spike spike NN cord-354029-mp5r82g4 580 8 protein protein NN cord-354029-mp5r82g4 580 9 quaternary quaternary JJ cord-354029-mp5r82g4 580 10 structure structure NN cord-354029-mp5r82g4 580 11 precedes precede VBZ cord-354029-mp5r82g4 580 12 virus virus NN cord-354029-mp5r82g4 580 13 penetration penetration NN cord-354029-mp5r82g4 580 14 into into IN cord-354029-mp5r82g4 580 15 cells cell NNS cord-354029-mp5r82g4 580 16 Evidence evidence NN cord-354029-mp5r82g4 580 17 for for IN cord-354029-mp5r82g4 580 18 H h NN cord-354029-mp5r82g4 580 19 + + CC cord-354029-mp5r82g4 580 20 -induced -induced JJ cord-354029-mp5r82g4 580 21 insertion insertion NN cord-354029-mp5r82g4 580 22 of of IN cord-354029-mp5r82g4 580 23 influenza influenza NN cord-354029-mp5r82g4 580 24 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 580 25 HA2 HA2 NNP cord-354029-mp5r82g4 580 26 N N NNP cord-354029-mp5r82g4 580 27 - - HYPH cord-354029-mp5r82g4 580 28 terminal terminal NN cord-354029-mp5r82g4 580 29 segment segment NN cord-354029-mp5r82g4 580 30 into into IN cord-354029-mp5r82g4 580 31 viral viral JJ cord-354029-mp5r82g4 580 32 membrane membrane NN cord-354029-mp5r82g4 580 33 Crystal Crystal NNP cord-354029-mp5r82g4 580 34 structure structure NN cord-354029-mp5r82g4 580 35 of of IN cord-354029-mp5r82g4 580 36 the the DT cord-354029-mp5r82g4 580 37 Ebola Ebola NNP cord-354029-mp5r82g4 580 38 virus virus NN cord-354029-mp5r82g4 580 39 membrane membrane NN cord-354029-mp5r82g4 580 40 fusion fusion NN cord-354029-mp5r82g4 580 41 subunit subunit NN cord-354029-mp5r82g4 580 42 , , , cord-354029-mp5r82g4 580 43 GP2 GP2 NNP cord-354029-mp5r82g4 580 44 , , , cord-354029-mp5r82g4 580 45 from from IN cord-354029-mp5r82g4 580 46 the the DT cord-354029-mp5r82g4 580 47 envelope envelope NN cord-354029-mp5r82g4 580 48 glycoprotein glycoprotein NN cord-354029-mp5r82g4 580 49 ectodomain ectodomain NNP cord-354029-mp5r82g4 580 50 Structural structural JJ cord-354029-mp5r82g4 580 51 basis basis NN cord-354029-mp5r82g4 580 52 for for IN cord-354029-mp5r82g4 580 53 membrane membrane NN cord-354029-mp5r82g4 580 54 fusion fusion NN cord-354029-mp5r82g4 580 55 by by IN cord-354029-mp5r82g4 580 56 enveloped envelop VBN cord-354029-mp5r82g4 580 57 viruses virus NNS cord-354029-mp5r82g4 580 58 Atomic atomic JJ cord-354029-mp5r82g4 580 59 structure structure NN cord-354029-mp5r82g4 580 60 of of IN cord-354029-mp5r82g4 580 61 the the DT cord-354029-mp5r82g4 580 62 ectodomain ectodomain NN cord-354029-mp5r82g4 580 63 from from IN cord-354029-mp5r82g4 580 64 HIV-1 HIV-1 NNP cord-354029-mp5r82g4 580 65 gp41 gp41 NNP cord-354029-mp5r82g4 580 66 Mutations Mutations NNP cord-354029-mp5r82g4 580 67 within within IN cord-354029-mp5r82g4 580 68 the the DT cord-354029-mp5r82g4 580 69 putative putative JJ cord-354029-mp5r82g4 580 70 membrane membrane NN cord-354029-mp5r82g4 580 71 - - HYPH cord-354029-mp5r82g4 580 72 spanning span VBG cord-354029-mp5r82g4 580 73 domain domain NN cord-354029-mp5r82g4 580 74 of of IN cord-354029-mp5r82g4 580 75 the the DT cord-354029-mp5r82g4 580 76 simian simian JJ cord-354029-mp5r82g4 580 77 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 580 78 virus virus NN cord-354029-mp5r82g4 580 79 transmembrane transmembrane NNP cord-354029-mp5r82g4 580 80 glycoprotein glycoprotein NN cord-354029-mp5r82g4 580 81 define define VBP cord-354029-mp5r82g4 580 82 the the DT cord-354029-mp5r82g4 580 83 minimal minimal JJ cord-354029-mp5r82g4 580 84 requirements requirement NNS cord-354029-mp5r82g4 580 85 for for IN cord-354029-mp5r82g4 580 86 fusion fusion NN cord-354029-mp5r82g4 580 87 , , , cord-354029-mp5r82g4 580 88 incorporation incorporation NN cord-354029-mp5r82g4 580 89 , , , cord-354029-mp5r82g4 580 90 and and CC cord-354029-mp5r82g4 580 91 infectivity infectivity NN cord-354029-mp5r82g4 580 92 Temperature temperature NN cord-354029-mp5r82g4 580 93 dependence dependence NN cord-354029-mp5r82g4 580 94 of of IN cord-354029-mp5r82g4 580 95 fusion fusion NN cord-354029-mp5r82g4 580 96 by by IN cord-354029-mp5r82g4 580 97 sendai sendai NNP cord-354029-mp5r82g4 580 98 virus virus NN cord-354029-mp5r82g4 580 99 pH ph NN cord-354029-mp5r82g4 580 100 - - HYPH cord-354029-mp5r82g4 580 101 dependent dependent JJ cord-354029-mp5r82g4 580 102 fusion fusion NN cord-354029-mp5r82g4 580 103 between between IN cord-354029-mp5r82g4 580 104 the the DT cord-354029-mp5r82g4 580 105 Semliki Semliki NNP cord-354029-mp5r82g4 580 106 Forest Forest NNP cord-354029-mp5r82g4 580 107 virus virus NN cord-354029-mp5r82g4 580 108 membrane membrane NN cord-354029-mp5r82g4 580 109 and and CC cord-354029-mp5r82g4 580 110 liposomes liposome VBD cord-354029-mp5r82g4 580 111 Fusion Fusion NNP cord-354029-mp5r82g4 580 112 of of IN cord-354029-mp5r82g4 580 113 Semliki Semliki NNP cord-354029-mp5r82g4 580 114 forest forest NN cord-354029-mp5r82g4 580 115 virus virus NN cord-354029-mp5r82g4 580 116 with with IN cord-354029-mp5r82g4 580 117 the the DT cord-354029-mp5r82g4 580 118 plasma plasma NN cord-354029-mp5r82g4 580 119 membrane membrane NN cord-354029-mp5r82g4 580 120 can can MD cord-354029-mp5r82g4 580 121 be be VB cord-354029-mp5r82g4 580 122 induced induce VBN cord-354029-mp5r82g4 580 123 by by IN cord-354029-mp5r82g4 580 124 low low JJ cord-354029-mp5r82g4 580 125 pH pH NNP cord-354029-mp5r82g4 580 126 Membrane membrane NN cord-354029-mp5r82g4 580 127 fusion fusion NN cord-354029-mp5r82g4 580 128 activity activity NN cord-354029-mp5r82g4 580 129 of of IN cord-354029-mp5r82g4 580 130 influenza influenza NN cord-354029-mp5r82g4 580 131 virus virus NN cord-354029-mp5r82g4 580 132 Viral viral JJ cord-354029-mp5r82g4 580 133 and and CC cord-354029-mp5r82g4 580 134 cellular cellular JJ cord-354029-mp5r82g4 580 135 membrane membrane NN cord-354029-mp5r82g4 580 136 fusion fusion NN cord-354029-mp5r82g4 580 137 proteins protein NNS cord-354029-mp5r82g4 580 138 Structure Structure NNP cord-354029-mp5r82g4 580 139 of of IN cord-354029-mp5r82g4 580 140 the the DT cord-354029-mp5r82g4 580 141 haemagglutinin haemagglutinin NNP cord-354029-mp5r82g4 580 142 membrane membrane NN cord-354029-mp5r82g4 580 143 glycoprotein glycoprotein NN cord-354029-mp5r82g4 580 144 of of IN cord-354029-mp5r82g4 580 145 influenza influenza NN cord-354029-mp5r82g4 580 146 virus virus NN cord-354029-mp5r82g4 580 147 at at IN cord-354029-mp5r82g4 580 148 3 3 CD cord-354029-mp5r82g4 580 149 resolution resolution NN cord-354029-mp5r82g4 580 150 Mutagenic mutagenic JJ cord-354029-mp5r82g4 580 151 stabilization stabilization NN cord-354029-mp5r82g4 580 152 and/ and/ NNP cord-354029-mp5r82g4 580 153 or or CC cord-354029-mp5r82g4 580 154 disruption disruption NN cord-354029-mp5r82g4 580 155 of of IN cord-354029-mp5r82g4 580 156 a a DT cord-354029-mp5r82g4 580 157 CD4-bound cd4-bound NN cord-354029-mp5r82g4 580 158 state state NN cord-354029-mp5r82g4 580 159 reveals reveal VBZ cord-354029-mp5r82g4 580 160 distinct distinct JJ cord-354029-mp5r82g4 580 161 conformations conformation NNS cord-354029-mp5r82g4 580 162 of of IN cord-354029-mp5r82g4 580 163 the the DT cord-354029-mp5r82g4 580 164 human human JJ cord-354029-mp5r82g4 580 165 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 580 166 virus virus NN cord-354029-mp5r82g4 580 167 type type NN cord-354029-mp5r82g4 580 168 1 1 CD cord-354029-mp5r82g4 580 169 gp120 gp120 CD cord-354029-mp5r82g4 580 170 envelope envelope NN cord-354029-mp5r82g4 580 171 glycoprotein glycoprotein NN cord-354029-mp5r82g4 580 172 Analysis analysis NN cord-354029-mp5r82g4 580 173 of of IN cord-354029-mp5r82g4 580 174 the the DT cord-354029-mp5r82g4 580 175 cell cell NN cord-354029-mp5r82g4 580 176 fusion fusion NN cord-354029-mp5r82g4 580 177 activities activity NNS cord-354029-mp5r82g4 580 178 of of IN cord-354029-mp5r82g4 580 179 chimeric chimeric JJ cord-354029-mp5r82g4 580 180 simian simian JJ cord-354029-mp5r82g4 580 181 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 580 182 virus virus NN cord-354029-mp5r82g4 580 183 - - HYPH cord-354029-mp5r82g4 580 184 murine murine JJ cord-354029-mp5r82g4 580 185 leukemia leukemia NN cord-354029-mp5r82g4 580 186 virus virus NN cord-354029-mp5r82g4 580 187 envelope envelope NN cord-354029-mp5r82g4 580 188 proteins protein NNS cord-354029-mp5r82g4 580 189 : : : cord-354029-mp5r82g4 580 190 inhibitory inhibitory JJ cord-354029-mp5r82g4 580 191 effects effect NNS cord-354029-mp5r82g4 580 192 of of IN cord-354029-mp5r82g4 580 193 the the DT cord-354029-mp5r82g4 580 194 R R NNP cord-354029-mp5r82g4 580 195 peptide peptide NN cord-354029-mp5r82g4 580 196 Observation observation NN cord-354029-mp5r82g4 580 197 of of IN cord-354029-mp5r82g4 580 198 a a DT cord-354029-mp5r82g4 580 199 membrane membrane NN cord-354029-mp5r82g4 580 200 fusion fusion NN cord-354029-mp5r82g4 580 201 intermediate intermediate JJ cord-354029-mp5r82g4 580 202 structure structure NNP cord-354029-mp5r82g4 580 203 Association Association NNP cord-354029-mp5r82g4 580 204 of of IN cord-354029-mp5r82g4 580 205 the the DT cord-354029-mp5r82g4 580 206 parainfluenza parainfluenza NNP cord-354029-mp5r82g4 580 207 virus virus NNP cord-354029-mp5r82g4 580 208 fusion fusion NNP cord-354029-mp5r82g4 580 209 and and CC cord-354029-mp5r82g4 580 210 hemagglutinin hemagglutinin NN cord-354029-mp5r82g4 580 211 - - HYPH cord-354029-mp5r82g4 580 212 neuraminidase neuraminidase NN cord-354029-mp5r82g4 580 213 glycoproteins glycoprotein NNS cord-354029-mp5r82g4 580 214 on on IN cord-354029-mp5r82g4 580 215 cell cell NN cord-354029-mp5r82g4 580 216 surfaces surface NNS cord-354029-mp5r82g4 580 217 Interaction Interaction NNP cord-354029-mp5r82g4 580 218 of of IN cord-354029-mp5r82g4 580 219 peptides peptide NNS cord-354029-mp5r82g4 580 220 with with IN cord-354029-mp5r82g4 580 221 sequences sequence NNS cord-354029-mp5r82g4 580 222 from from IN cord-354029-mp5r82g4 580 223 the the DT cord-354029-mp5r82g4 580 224 Newcastle Newcastle NNP cord-354029-mp5r82g4 580 225 disease disease NN cord-354029-mp5r82g4 580 226 virus virus NN cord-354029-mp5r82g4 580 227 fusion fusion NN cord-354029-mp5r82g4 580 228 protein protein NNP cord-354029-mp5r82g4 580 229 heptad heptad NNP cord-354029-mp5r82g4 580 230 repeat repeat NN cord-354029-mp5r82g4 580 231 regions region NNS cord-354029-mp5r82g4 580 232 Fusion Fusion NNP cord-354029-mp5r82g4 580 233 of of IN cord-354029-mp5r82g4 580 234 bovine bovine JJ cord-354029-mp5r82g4 580 235 leukemia leukemia NN cord-354029-mp5r82g4 580 236 virus virus NN cord-354029-mp5r82g4 580 237 with with IN cord-354029-mp5r82g4 580 238 target target NN cord-354029-mp5r82g4 580 239 cells cell NNS cord-354029-mp5r82g4 580 240 monitored monitor VBN cord-354029-mp5r82g4 580 241 by by IN cord-354029-mp5r82g4 580 242 R18 R18 NNP cord-354029-mp5r82g4 580 243 fluorescence fluorescence NN cord-354029-mp5r82g4 580 244 and and CC cord-354029-mp5r82g4 580 245 PCR PCR NNP cord-354029-mp5r82g4 580 246 assays assay NNS cord-354029-mp5r82g4 581 1 Proper proper JJ cord-354029-mp5r82g4 581 2 spacing spacing NN cord-354029-mp5r82g4 581 3 between between IN cord-354029-mp5r82g4 581 4 heptad heptad NN cord-354029-mp5r82g4 581 5 repeat repeat NN cord-354029-mp5r82g4 581 6 B b NN cord-354029-mp5r82g4 581 7 and and CC cord-354029-mp5r82g4 581 8 the the DT cord-354029-mp5r82g4 581 9 transmembrane transmembrane NNP cord-354029-mp5r82g4 581 10 domain domain NN cord-354029-mp5r82g4 581 11 boundary boundary NN cord-354029-mp5r82g4 581 12 of of IN cord-354029-mp5r82g4 581 13 the the DT cord-354029-mp5r82g4 581 14 paramyxovirus paramyxovirus NNP cord-354029-mp5r82g4 581 15 SV5 SV5 NNP cord-354029-mp5r82g4 581 16 F F NNP cord-354029-mp5r82g4 581 17 protein protein NN cord-354029-mp5r82g4 581 18 is be VBZ cord-354029-mp5r82g4 581 19 critical critical JJ cord-354029-mp5r82g4 581 20 for for IN cord-354029-mp5r82g4 581 21 biological biological JJ cord-354029-mp5r82g4 581 22 activity activity NN cord-354029-mp5r82g4 582 1 Acknowledgements acknowledgement NNS cord-354029-mp5r82g4 582 2 Work work VBP cord-354029-mp5r82g4 582 3 in in IN cord-354029-mp5r82g4 582 4 the the DT cord-354029-mp5r82g4 582 5 authors author NNS cord-354029-mp5r82g4 582 6 laboratory laboratory NN cord-354029-mp5r82g4 582 7 was be VBD cord-354029-mp5r82g4 582 8 supported support VBN cord-354029-mp5r82g4 582 9 by by IN cord-354029-mp5r82g4 582 10 the the DT cord-354029-mp5r82g4 582 11 NIH NIH NNP cord-354029-mp5r82g4 582 12 ( ( -LRB- cord-354029-mp5r82g4 582 13 AI22470 ai22470 NN cord-354029-mp5r82g4 582 14 ) ) -RRB- cord-354029-mp5r82g4 582 15 . . . cord-354029-mp5r82g4 583 1 We -PRON- PRP cord-354029-mp5r82g4 583 2 thank thank VBP cord-354029-mp5r82g4 583 3 Dr. Dr. NNP cord-354029-mp5r82g4 583 4 Margaret Margaret NNP cord-354029-mp5r82g4 583 5 Kielian Kielian NNP cord-354029-mp5r82g4 583 6 for for IN cord-354029-mp5r82g4 583 7 helpful helpful JJ cord-354029-mp5r82g4 583 8 comments comment NNS cord-354029-mp5r82g4 583 9 on on IN cord-354029-mp5r82g4 583 10 the the DT cord-354029-mp5r82g4 583 11 manuscript manuscript NN cord-354029-mp5r82g4 583 12 . . . cord-354029-mp5r82g4 584 1 Abrahamyan Abrahamyan NNP cord-354029-mp5r82g4 584 2 LG LG NNP cord-354029-mp5r82g4 584 3 , , , cord-354029-mp5r82g4 584 4 Markosyan Markosyan NNP cord-354029-mp5r82g4 584 5 RM RM NNP cord-354029-mp5r82g4 584 6 , , , cord-354029-mp5r82g4 584 7 Moore Moore NNP cord-354029-mp5r82g4 584 8 JP JP NNP cord-354029-mp5r82g4 584 9 , , , cord-354029-mp5r82g4 584 10 Cohen Cohen NNP cord-354029-mp5r82g4 584 11 FS FS NNP cord-354029-mp5r82g4 584 12 , , , cord-354029-mp5r82g4 584 13 and and CC cord-354029-mp5r82g4 584 14 Melikyan Melikyan NNP cord-354029-mp5r82g4 584 15 GB GB NNP cord-354029-mp5r82g4 584 16 ( ( -LRB- cord-354029-mp5r82g4 584 17 2003 2003 CD cord-354029-mp5r82g4 584 18 ) ) -RRB- cord-354029-mp5r82g4 585 1 Human human JJ cord-354029-mp5r82g4 585 2 immunodeficiency immunodeficiency NN cord-354029-mp5r82g4 585 3 virus virus NN cord-354029-mp5r82g4 585 4 type type NN cord-354029-mp5r82g4 585 5 1 1 CD cord-354029-mp5r82g4 585 6 Env Env NNP cord-354029-mp5r82g4 585 7 with with IN cord-354029-mp5r82g4 585 8 an an DT cord-354029-mp5r82g4 585 9 intersubunit intersubunit JJ cord-354029-mp5r82g4 585 10 disulfide disulfide NN cord-354029-mp5r82g4 585 11 bond bond NN cord-354029-mp5r82g4 585 12 engages engage VBZ cord-354029-mp5r82g4 585 13 coreceptors coreceptor NNS cord-354029-mp5r82g4 585 14 but but CC cord-354029-mp5r82g4 585 15 requires require VBZ cord-354029-mp5r82g4 585 16 bond bond NN cord-354029-mp5r82g4 585 17 reduction reduction NN cord-354029-mp5r82g4 585 18 after after IN cord-354029-mp5r82g4 585 19 engagement engagement NN cord-354029-mp5r82g4 585 20 to to TO cord-354029-mp5r82g4 585 21 induce induce VB cord-354029-mp5r82g4 585 22 fusion fusion NN cord-354029-mp5r82g4 585 23 . . . cord-354029-mp5r82g4 586 1 J J NNP cord-354029-mp5r82g4 586 2 Virol Virol NNP cord-354029-mp5r82g4 586 3 77:5829 77:5829 CD cord-354029-mp5r82g4 586 4 - - SYM cord-354029-mp5r82g4 586 5 36 36 CD cord-354029-mp5r82g4 587 1 Aguilar Aguilar NNP cord-354029-mp5r82g4 587 2 HC HC NNP cord-354029-mp5r82g4 587 3 , , , cord-354029-mp5r82g4 587 4 Anderson Anderson NNP cord-354029-mp5r82g4 587 5 WF WF NNP cord-354029-mp5r82g4 587 6 , , , cord-354029-mp5r82g4 587 7 and and CC cord-354029-mp5r82g4 587 8 Cannon Cannon NNP cord-354029-mp5r82g4 587 9 PM PM NNP cord-354029-mp5r82g4 587 10 ( ( -LRB- cord-354029-mp5r82g4 587 11 2003 2003 CD cord-354029-mp5r82g4 587 12 ) ) -RRB- cord-354029-mp5r82g4 587 13 _SP