id sid tid token lemma pos cord-346153-9162w7il 1 1 key key JJ cord-346153-9162w7il 1 2 : : : cord-346153-9162w7il 1 3 cord-346153 cord-346153 NNP cord-346153-9162w7il 1 4 - - HYPH cord-346153-9162w7il 1 5 9162w7il 9162w7il CD cord-346153-9162w7il 1 6 authors author NNS cord-346153-9162w7il 1 7 : : : cord-346153-9162w7il 1 8 Openshaw Openshaw NNP cord-346153-9162w7il 1 9 , , , cord-346153-9162w7il 1 10 P P NNP cord-346153-9162w7il 1 11 J J NNP cord-346153-9162w7il 1 12 title title NN cord-346153-9162w7il 1 13 : : : cord-346153-9162w7il 2 1 Crossing crossing NN cord-346153-9162w7il 2 2 barriers barrier NNS cord-346153-9162w7il 2 3 : : : cord-346153-9162w7il 2 4 infections infection NNS cord-346153-9162w7il 2 5 of of IN cord-346153-9162w7il 2 6 the the DT cord-346153-9162w7il 2 7 lung lung NN cord-346153-9162w7il 2 8 and and CC cord-346153-9162w7il 2 9 the the DT cord-346153-9162w7il 2 10 gut gut NN cord-346153-9162w7il 2 11 date date NN cord-346153-9162w7il 2 12 : : : cord-346153-9162w7il 2 13 2008 2008 CD cord-346153-9162w7il 2 14 - - SYM cord-346153-9162w7il 2 15 12 12 CD cord-346153-9162w7il 2 16 - - HYPH cord-346153-9162w7il 2 17 24 24 CD cord-346153-9162w7il 2 18 journal journal NN cord-346153-9162w7il 2 19 : : : cord-346153-9162w7il 2 20 Mucosal Mucosal NNP cord-346153-9162w7il 2 21 Immunol Immunol NNP cord-346153-9162w7il 2 22 DOI DOI NNP cord-346153-9162w7il 2 23 : : : cord-346153-9162w7il 3 1 10.1038 10.1038 CD cord-346153-9162w7il 3 2 / / SYM cord-346153-9162w7il 3 3 mi.2008.79 mi.2008.79 NNP cord-346153-9162w7il 3 4 sha sha NNP cord-346153-9162w7il 3 5 : : : cord-346153-9162w7il 3 6 8da758ac8aca22a81f23193025103c3a27c02709 8da758ac8aca22a81f23193025103c3a27c02709 CD cord-346153-9162w7il 3 7 doc_id doc_id CD cord-346153-9162w7il 3 8 : : : cord-346153-9162w7il 3 9 346153 346153 CD cord-346153-9162w7il 3 10 cord_uid cord_uid NNS cord-346153-9162w7il 3 11 : : : cord-346153-9162w7il 3 12 9162w7il 9162w7il CD cord-346153-9162w7il 4 1 Although although IN cord-346153-9162w7il 4 2 known know VBN cord-346153-9162w7il 4 3 as as IN cord-346153-9162w7il 4 4 respiratory respiratory JJ cord-346153-9162w7il 4 5 pathogens pathogen NNS cord-346153-9162w7il 4 6 , , , cord-346153-9162w7il 4 7 severe severe JJ cord-346153-9162w7il 4 8 acute acute JJ cord-346153-9162w7il 4 9 respiratory respiratory JJ cord-346153-9162w7il 4 10 syndrome syndrome NN cord-346153-9162w7il 4 11 ( ( -LRB- cord-346153-9162w7il 4 12 SARS SARS NNP cord-346153-9162w7il 4 13 ) ) -RRB- cord-346153-9162w7il 4 14 and and CC cord-346153-9162w7il 4 15 its -PRON- PRP$ cord-346153-9162w7il 4 16 sister sister NN cord-346153-9162w7il 4 17 coronaviruses coronaviruse NNS cord-346153-9162w7il 4 18 frequently frequently RB cord-346153-9162w7il 4 19 cause cause VBP cord-346153-9162w7il 4 20 enteric enteric JJ cord-346153-9162w7il 4 21 symptoms symptom NNS cord-346153-9162w7il 4 22 . . . cord-346153-9162w7il 5 1 In in IN cord-346153-9162w7il 5 2 addition addition NN cord-346153-9162w7il 5 3 , , , cord-346153-9162w7il 5 4 other other JJ cord-346153-9162w7il 5 5 classically classically RB cord-346153-9162w7il 5 6 non non JJ cord-346153-9162w7il 5 7 - - JJ cord-346153-9162w7il 5 8 enteric enteric JJ cord-346153-9162w7il 5 9 viruses virus NNS cord-346153-9162w7il 5 10 ( ( -LRB- cord-346153-9162w7il 5 11 such such JJ cord-346153-9162w7il 5 12 as as IN cord-346153-9162w7il 5 13 HIV HIV NNP cord-346153-9162w7il 5 14 and and CC cord-346153-9162w7il 5 15 influenza influenza NN cord-346153-9162w7il 5 16 ) ) -RRB- cord-346153-9162w7il 5 17 may may MD cord-346153-9162w7il 5 18 also also RB cord-346153-9162w7il 5 19 have have VB cord-346153-9162w7il 5 20 enteric enteric JJ cord-346153-9162w7il 5 21 effects effect NNS cord-346153-9162w7il 5 22 that that WDT cord-346153-9162w7il 5 23 are be VBP cord-346153-9162w7il 5 24 crucial crucial JJ cord-346153-9162w7il 5 25 in in IN cord-346153-9162w7il 5 26 their -PRON- PRP$ cord-346153-9162w7il 5 27 pathogeneses pathogenese NNS cord-346153-9162w7il 5 28 . . . cord-346153-9162w7il 6 1 These these DT cord-346153-9162w7il 6 2 effects effect NNS cord-346153-9162w7il 6 3 can can MD cord-346153-9162w7il 6 4 be be VB cord-346153-9162w7il 6 5 due due JJ cord-346153-9162w7il 6 6 to to IN cord-346153-9162w7il 6 7 direct direct JJ cord-346153-9162w7il 6 8 infection infection NN cord-346153-9162w7il 6 9 of of IN cord-346153-9162w7il 6 10 the the DT cord-346153-9162w7il 6 11 gut gut NN cord-346153-9162w7il 6 12 mucosa mucosa NN cord-346153-9162w7il 6 13 , , , cord-346153-9162w7il 6 14 but but CC cord-346153-9162w7il 6 15 can can MD cord-346153-9162w7il 6 16 also also RB cord-346153-9162w7il 6 17 be be VB cord-346153-9162w7il 6 18 because because IN cord-346153-9162w7il 6 19 of of IN cord-346153-9162w7il 6 20 decreased decrease VBN cord-346153-9162w7il 6 21 antibacterial antibacterial JJ cord-346153-9162w7il 6 22 defenses defense NNS cord-346153-9162w7il 6 23 , , , cord-346153-9162w7il 6 24 increased increase VBN cord-346153-9162w7il 6 25 mucosal mucosal JJ cord-346153-9162w7il 6 26 permeability permeability NN cord-346153-9162w7il 6 27 , , , cord-346153-9162w7il 6 28 bacterial bacterial JJ cord-346153-9162w7il 6 29 translocation translocation NN cord-346153-9162w7il 6 30 , , , cord-346153-9162w7il 6 31 and and CC cord-346153-9162w7il 6 32 systemic systemic JJ cord-346153-9162w7il 6 33 leak leak NN cord-346153-9162w7il 6 34 of of IN cord-346153-9162w7il 6 35 endotoxin endotoxin NN cord-346153-9162w7il 6 36 . . . cord-346153-9162w7il 7 1 SUPPLEMENTARY supplementary JJ cord-346153-9162w7il 7 2 INFORMATION information NN cord-346153-9162w7il 7 3 : : : cord-346153-9162w7il 8 1 The the DT cord-346153-9162w7il 8 2 online online JJ cord-346153-9162w7il 8 3 version version NN cord-346153-9162w7il 8 4 of of IN cord-346153-9162w7il 8 5 this this DT cord-346153-9162w7il 8 6 article article NN cord-346153-9162w7il 8 7 ( ( -LRB- cord-346153-9162w7il 8 8 doi:10.1038 doi:10.1038 NNP cord-346153-9162w7il 8 9 / / SYM cord-346153-9162w7il 8 10 mi.2008.79 mi.2008.79 NNP cord-346153-9162w7il 8 11 ) ) -RRB- cord-346153-9162w7il 8 12 contains contain VBZ cord-346153-9162w7il 8 13 supplementary supplementary JJ cord-346153-9162w7il 8 14 material material NN cord-346153-9162w7il 8 15 , , , cord-346153-9162w7il 8 16 which which WDT cord-346153-9162w7il 8 17 is be VBZ cord-346153-9162w7il 8 18 available available JJ cord-346153-9162w7il 8 19 to to IN cord-346153-9162w7il 8 20 authorized authorize VBN cord-346153-9162w7il 8 21 users user NNS cord-346153-9162w7il 8 22 . . . cord-346153-9162w7il 9 1 When when WRB cord-346153-9162w7il 9 2 SARS SARS NNP cord-346153-9162w7il 9 3 broke break VBD cord-346153-9162w7il 9 4 out out RP cord-346153-9162w7il 9 5 in in IN cord-346153-9162w7il 9 6 the the DT cord-346153-9162w7il 9 7 winter winter NN cord-346153-9162w7il 9 8 of of IN cord-346153-9162w7il 9 9 2002 2002 CD cord-346153-9162w7il 9 10 -2003 -2003 RBR cord-346153-9162w7il 9 11 , , , cord-346153-9162w7il 9 12 the the DT cord-346153-9162w7il 9 13 world world NN cord-346153-9162w7il 9 14 was be VBD cord-346153-9162w7il 9 15 gripped grip VBN cord-346153-9162w7il 9 16 by by IN cord-346153-9162w7il 9 17 a a DT cord-346153-9162w7il 9 18 well well RB cord-346153-9162w7il 9 19 - - HYPH cord-346153-9162w7il 9 20 founded found VBN cord-346153-9162w7il 9 21 fear fear NN cord-346153-9162w7il 9 22 that that IN cord-346153-9162w7il 9 23 it -PRON- PRP cord-346153-9162w7il 9 24 would would MD cord-346153-9162w7il 9 25 become become VB cord-346153-9162w7il 9 26 a a DT cord-346153-9162w7il 9 27 lethal lethal JJ cord-346153-9162w7il 9 28 pandemic pandemic NN cord-346153-9162w7il 9 29 . . . cord-346153-9162w7il 10 1 e e LS cord-346153-9162w7il 10 2 acronym acronym NN cord-346153-9162w7il 10 3 resonated resonate VBD cord-346153-9162w7il 10 4 with with IN cord-346153-9162w7il 10 5 the the DT cord-346153-9162w7il 10 6 public public NN cord-346153-9162w7il 10 7 , , , cord-346153-9162w7il 10 8 helping help VBG cord-346153-9162w7il 10 9 to to TO cord-346153-9162w7il 10 10 focus focus VB cord-346153-9162w7il 10 11 attention attention NN cord-346153-9162w7il 10 12 not not RB cord-346153-9162w7il 10 13 only only RB cord-346153-9162w7il 10 14 on on IN cord-346153-9162w7il 10 15 the the DT cord-346153-9162w7il 10 16 virus virus NN cord-346153-9162w7il 10 17 but but CC cord-346153-9162w7il 10 18 also also RB cord-346153-9162w7il 10 19 on on IN cord-346153-9162w7il 10 20 its -PRON- PRP$ cord-346153-9162w7il 10 21 transmissibility transmissibility NN cord-346153-9162w7il 10 22 and and CC cord-346153-9162w7il 10 23 global global JJ cord-346153-9162w7il 10 24 potential potential NN cord-346153-9162w7il 10 25 . . . cord-346153-9162w7il 11 1 e e LS cord-346153-9162w7il 11 2 original original JJ cord-346153-9162w7il 11 3 animal animal NN cord-346153-9162w7il 11 4 reservoir reservoir NN cord-346153-9162w7il 11 5 of of IN cord-346153-9162w7il 11 6 the the DT cord-346153-9162w7il 11 7 SARS SARS NNP cord-346153-9162w7il 11 8 coronavirus coronavirus NN cord-346153-9162w7il 11 9 appears appear VBZ cord-346153-9162w7il 11 10 to to TO cord-346153-9162w7il 11 11 be be VB cord-346153-9162w7il 11 12 wild wild JJ cord-346153-9162w7il 11 13 bats bat NNS cord-346153-9162w7il 11 14 , , , cord-346153-9162w7il 11 15 although although IN cord-346153-9162w7il 11 16 it -PRON- PRP cord-346153-9162w7il 11 17 probably probably RB cord-346153-9162w7il 11 18 adapted adapt VBD cord-346153-9162w7il 11 19 to to TO cord-346153-9162w7il 11 20 infect infect VB cord-346153-9162w7il 11 21 nocturnal nocturnal JJ cord-346153-9162w7il 11 22 pine pine JJ cord-346153-9162w7il 11 23 civet civet NN cord-346153-9162w7il 11 24 cats cat NNS cord-346153-9162w7il 11 25 before before IN cord-346153-9162w7il 11 26 moving move VBG cord-346153-9162w7il 11 27 in in RB cord-346153-9162w7il 11 28 to to IN cord-346153-9162w7il 11 29 man man NN cord-346153-9162w7il 11 30 . . . cord-346153-9162w7il 12 1 4 4 LS cord-346153-9162w7il 13 1 Although although IN cord-346153-9162w7il 13 2 SARS SARS NNP cord-346153-9162w7il 13 3 was be VBD cord-346153-9162w7il 13 4 dubbed dub VBN cord-346153-9162w7il 13 5 " " `` cord-346153-9162w7il 13 6 respiratory respiratory JJ cord-346153-9162w7il 13 7 " " '' cord-346153-9162w7il 13 8 , , , cord-346153-9162w7il 13 9 the the DT cord-346153-9162w7il 13 10 virus virus NN cord-346153-9162w7il 13 11 was be VBD cord-346153-9162w7il 13 12 clearly clearly RB cord-346153-9162w7il 13 13 not not RB cord-346153-9162w7il 13 14 just just RB cord-346153-9162w7il 13 15 a a DT cord-346153-9162w7il 13 16 lung lung NN cord-346153-9162w7il 13 17 pathogen pathogen NN cord-346153-9162w7il 13 18 -it -it . cord-346153-9162w7il 14 1 also also RB cord-346153-9162w7il 14 2 a a DT cord-346153-9162w7il 14 3 ected ecte VBN cord-346153-9162w7il 14 4 the the DT cord-346153-9162w7il 14 5 gut gut NN cord-346153-9162w7il 14 6 . . . cord-346153-9162w7il 15 1 e e LS cord-346153-9162w7il 15 2 emerging emerge VBG cord-346153-9162w7il 15 3 epidemic epidemic NN cord-346153-9162w7il 15 4 came come VBD cord-346153-9162w7il 15 5 to to IN cord-346153-9162w7il 15 6 the the DT cord-346153-9162w7il 15 7 attention attention NN cord-346153-9162w7il 15 8 of of IN cord-346153-9162w7il 15 9 virologists virologist NNS cord-346153-9162w7il 15 10 when when WRB cord-346153-9162w7il 15 11 it -PRON- PRP cord-346153-9162w7il 15 12 began begin VBD cord-346153-9162w7il 15 13 to to TO cord-346153-9162w7il 15 14 spread spread VB cord-346153-9162w7il 15 15 in in IN cord-346153-9162w7il 15 16 Hong Hong NNP cord-346153-9162w7il 15 17 Kong Kong NNP cord-346153-9162w7il 15 18 in in IN cord-346153-9162w7il 15 19 early early JJ cord-346153-9162w7il 15 20 March March NNP cord-346153-9162w7il 15 21 2002 2002 CD cord-346153-9162w7il 15 22 . . . cord-346153-9162w7il 16 1 One one CD cord-346153-9162w7il 16 2 of of IN cord-346153-9162w7il 16 3 the the DT cord-346153-9162w7il 16 4 rst rst JJ cord-346153-9162w7il 16 5 major major JJ cord-346153-9162w7il 16 6 outbreaks outbreak NNS cord-346153-9162w7il 16 7 was be VBD cord-346153-9162w7il 16 8 in in IN cord-346153-9162w7il 16 9 a a DT cord-346153-9162w7il 16 10 hospital hospital NN cord-346153-9162w7il 16 11 , , , cord-346153-9162w7il 16 12 triggered trigger VBN cord-346153-9162w7il 16 13 by by IN cord-346153-9162w7il 16 14 a a DT cord-346153-9162w7il 16 15 " " `` cord-346153-9162w7il 16 16 superspreading superspreade VBG cord-346153-9162w7il 16 17 " " '' cord-346153-9162w7il 16 18 event event NN cord-346153-9162w7il 16 19 following follow VBG cord-346153-9162w7il 16 20 the the DT cord-346153-9162w7il 16 21 admission admission NN cord-346153-9162w7il 16 22 of of IN cord-346153-9162w7il 16 23 a a DT cord-346153-9162w7il 16 24 doctor doctor NN cord-346153-9162w7il 16 25 who who WP cord-346153-9162w7il 16 26 had have VBD cord-346153-9162w7il 16 27 acquired acquire VBN cord-346153-9162w7il 16 28 the the DT cord-346153-9162w7il 16 29 infection infection NN cord-346153-9162w7il 16 30 while while IN cord-346153-9162w7il 16 31 working work VBG cord-346153-9162w7il 16 32 with with IN cord-346153-9162w7il 16 33 patients patient NNS cord-346153-9162w7il 16 34 with with IN cord-346153-9162w7il 16 35 atypical atypical JJ cord-346153-9162w7il 16 36 pneumonia pneumonia NN cord-346153-9162w7il 16 37 in in IN cord-346153-9162w7il 16 38 Guangdong Guangdong NNP cord-346153-9162w7il 16 39 Province Province NNP cord-346153-9162w7il 16 40 of of IN cord-346153-9162w7il 16 41 mainland mainland NN cord-346153-9162w7il 16 42 China China NNP cord-346153-9162w7il 16 43 . . . cord-346153-9162w7il 17 1 In in IN cord-346153-9162w7il 17 2 all all DT cord-346153-9162w7il 17 3 , , , cord-346153-9162w7il 17 4 70 70 CD cord-346153-9162w7il 17 5 hospital hospital NN cord-346153-9162w7il 17 6 sta sta NNP cord-346153-9162w7il 17 7 became become VBD cord-346153-9162w7il 17 8 infected infected JJ cord-346153-9162w7il 17 9 in in IN cord-346153-9162w7il 17 10 this this DT cord-346153-9162w7il 17 11 one one CD cord-346153-9162w7il 17 12 outbreak outbreak NN cord-346153-9162w7il 17 13 ; ; : cord-346153-9162w7il 17 14 this this DT cord-346153-9162w7il 17 15 same same JJ cord-346153-9162w7il 17 16 index index NN cord-346153-9162w7il 17 17 case case NN cord-346153-9162w7il 17 18 apparently apparently RB cord-346153-9162w7il 17 19 infected infect VBD cord-346153-9162w7il 17 20 visitors visitor NNS cord-346153-9162w7il 17 21 to to IN cord-346153-9162w7il 17 22 the the DT cord-346153-9162w7il 17 23 hotel hotel NN cord-346153-9162w7il 17 24 where where WRB cord-346153-9162w7il 17 25 the the DT cord-346153-9162w7il 17 26 doctor doctor NN cord-346153-9162w7il 17 27 stayed stay VBD cord-346153-9162w7il 17 28 , , , cord-346153-9162w7il 17 29 one one CD cord-346153-9162w7il 17 30 of of IN cord-346153-9162w7il 17 31 whom whom WP cord-346153-9162w7il 17 32 ew ew UH cord-346153-9162w7il 17 33 to to IN cord-346153-9162w7il 17 34 Hanoi Hanoi NNP cord-346153-9162w7il 17 35 , , , cord-346153-9162w7il 17 36 was be VBD cord-346153-9162w7il 17 37 admitted admit VBN cord-346153-9162w7il 17 38 to to IN cord-346153-9162w7il 17 39 hospital hospital NN cord-346153-9162w7il 17 40 and and CC cord-346153-9162w7il 17 41 there there RB cord-346153-9162w7il 17 42 led lead VBD cord-346153-9162w7il 17 43 to to IN cord-346153-9162w7il 17 44 an an DT cord-346153-9162w7il 17 45 outbreak outbreak NN cord-346153-9162w7il 17 46 in in IN cord-346153-9162w7il 17 47 which which WDT cord-346153-9162w7il 17 48 63 63 CD cord-346153-9162w7il 17 49 hospital hospital NN cord-346153-9162w7il 17 50 sta sta NNP cord-346153-9162w7il 17 51 were be VBD cord-346153-9162w7il 17 52 infected infect VBN cord-346153-9162w7il 17 53 . . . cord-346153-9162w7il 18 1 Events event NNS cord-346153-9162w7il 18 2 in in IN cord-346153-9162w7il 18 3 the the DT cord-346153-9162w7il 18 4 same same JJ cord-346153-9162w7il 18 5 hotel hotel NN cord-346153-9162w7il 18 6 probably probably RB cord-346153-9162w7il 18 7 led lead VBD cord-346153-9162w7il 18 8 to to IN cord-346153-9162w7il 18 9 the the DT cord-346153-9162w7il 18 10 transmission transmission NN cord-346153-9162w7il 18 11 of of IN cord-346153-9162w7il 18 12 infection infection NN cord-346153-9162w7il 18 13 to to IN cord-346153-9162w7il 18 14 Toronto Toronto NNP cord-346153-9162w7il 18 15 , , , cord-346153-9162w7il 18 16 where where WRB cord-346153-9162w7il 18 17 a a DT cord-346153-9162w7il 18 18 major major JJ cord-346153-9162w7il 18 19 outbreak outbreak NN cord-346153-9162w7il 18 20 also also RB cord-346153-9162w7il 18 21 occurred occur VBD cord-346153-9162w7il 18 22 . . . cord-346153-9162w7il 19 1 The the DT cord-346153-9162w7il 19 2 major major JJ cord-346153-9162w7il 19 3 community community NN cord-346153-9162w7il 19 4 transmission transmission NN cord-346153-9162w7il 19 5 in in IN cord-346153-9162w7il 19 6 Hong Hong NNP cord-346153-9162w7il 19 7 Kong Kong NNP cord-346153-9162w7il 19 8 occurred occur VBD cord-346153-9162w7il 19 9 in in IN cord-346153-9162w7il 19 10 a a DT cord-346153-9162w7il 19 11 tower tower NN cord-346153-9162w7il 19 12 block block NN cord-346153-9162w7il 19 13 complex complex NN cord-346153-9162w7il 19 14 named name VBN cord-346153-9162w7il 19 15 Amoy Amoy NNP cord-346153-9162w7il 19 16 Gardens Gardens NNPS cord-346153-9162w7il 19 17 . . . cord-346153-9162w7il 20 1 In in IN cord-346153-9162w7il 20 2 this this DT cord-346153-9162w7il 20 3 case case NN cord-346153-9162w7il 20 4 , , , cord-346153-9162w7il 20 5 the the DT cord-346153-9162w7il 20 6 evidence evidence NN cord-346153-9162w7il 20 7 points point VBZ cord-346153-9162w7il 20 8 to to IN cord-346153-9162w7il 20 9 transmission transmission NN cord-346153-9162w7il 20 10 from from IN cord-346153-9162w7il 20 11 soil soil NN cord-346153-9162w7il 20 12 pipes pipe NNS cord-346153-9162w7il 20 13 and and CC cord-346153-9162w7il 20 14 sewage sewage NN cord-346153-9162w7il 20 15 which which WDT cord-346153-9162w7il 20 16 appears appear VBZ cord-346153-9162w7il 20 17 to to TO cord-346153-9162w7il 20 18 have have VB cord-346153-9162w7il 20 19 led lead VBN cord-346153-9162w7il 20 20 to to IN cord-346153-9162w7il 20 21 aerosolization aerosolization NN cord-346153-9162w7il 20 22 of of IN cord-346153-9162w7il 20 23 SARS SARS NNP cord-346153-9162w7il 20 24 coronavirus coronavirus NN cord-346153-9162w7il 20 25 , , , cord-346153-9162w7il 20 26 and and CC cord-346153-9162w7il 20 27 to to IN cord-346153-9162w7il 20 28 inhalation inhalation NN cord-346153-9162w7il 20 29 and and CC cord-346153-9162w7il 20 30 transmission transmission NN cord-346153-9162w7il 20 31 to to IN cord-346153-9162w7il 20 32 approximately approximately RB cord-346153-9162w7il 20 33 331 331 CD cord-346153-9162w7il 20 34 new new JJ cord-346153-9162w7il 20 35 individuals individual NNS cord-346153-9162w7il 20 36 . . . cord-346153-9162w7il 21 1 This this DT cord-346153-9162w7il 21 2 alarming alarming JJ cord-346153-9162w7il 21 3 ability ability NN cord-346153-9162w7il 21 4 to to TO cord-346153-9162w7il 21 5 swop swop VB cord-346153-9162w7il 21 6 between between IN cord-346153-9162w7il 21 7 being be VBG cord-346153-9162w7il 21 8 a a DT cord-346153-9162w7il 21 9 respiratory respiratory NN cord-346153-9162w7il 21 10 and and CC cord-346153-9162w7il 21 11 a a DT cord-346153-9162w7il 21 12 gastrointestinal gastrointestinal JJ cord-346153-9162w7il 21 13 pathogen pathogen NN cord-346153-9162w7il 21 14 was be VBD cord-346153-9162w7il 21 15 one one CD cord-346153-9162w7il 21 16 of of IN cord-346153-9162w7il 21 17 the the DT cord-346153-9162w7il 21 18 features feature NNS cord-346153-9162w7il 21 19 made make VBD cord-346153-9162w7il 21 20 SARS SARS NNP cord-346153-9162w7il 21 21 so so RB cord-346153-9162w7il 21 22 potentially potentially RB cord-346153-9162w7il 21 23 devastating devastating JJ cord-346153-9162w7il 21 24 . . . cord-346153-9162w7il 22 1 Molecular molecular JJ cord-346153-9162w7il 22 2 detection detection NN cord-346153-9162w7il 22 3 methods method NNS cord-346153-9162w7il 22 4 show show VBP cord-346153-9162w7il 22 5 that that IN cord-346153-9162w7il 22 6 picornaviruses picornaviruses NNP cord-346153-9162w7il 22 7 ( ( -LRB- cord-346153-9162w7il 22 8 rhinovirus rhinovirus NN cord-346153-9162w7il 22 9 and and CC cord-346153-9162w7il 22 10 enterovirus enterovirus NN cord-346153-9162w7il 22 11 ) ) -RRB- cord-346153-9162w7il 22 12 cause cause VB cord-346153-9162w7il 22 13 approximately approximately RB cord-346153-9162w7il 22 14 60 60 CD cord-346153-9162w7il 22 15 % % NN cord-346153-9162w7il 22 16 of of IN cord-346153-9162w7il 22 17 common common JJ cord-346153-9162w7il 22 18 colds cold NNS cord-346153-9162w7il 22 19 in in IN cord-346153-9162w7il 22 20 older old JJR cord-346153-9162w7il 22 21 children child NNS cord-346153-9162w7il 22 22 and and CC cord-346153-9162w7il 22 23 adults adult NNS cord-346153-9162w7il 22 24 . . . cord-346153-9162w7il 23 1 e e LS cord-346153-9162w7il 23 2 next next RB cord-346153-9162w7il 23 3 most most RBS cord-346153-9162w7il 23 4 common common JJ cord-346153-9162w7il 23 5 are be VBP cord-346153-9162w7il 23 6 the the DT cord-346153-9162w7il 23 7 coronaviruses coronaviruse NNS cord-346153-9162w7il 23 8 , , , cord-346153-9162w7il 23 9 causing cause VBG cord-346153-9162w7il 23 10 about about RB cord-346153-9162w7il 23 11 15 15 CD cord-346153-9162w7il 23 12 % % NN cord-346153-9162w7il 23 13 of of IN cord-346153-9162w7il 23 14 colds cold NNS cord-346153-9162w7il 23 15 . . . cord-346153-9162w7il 24 1 Human human JJ cord-346153-9162w7il 24 2 coronaviruses coronaviruse NNS cord-346153-9162w7il 24 3 are be VBP cord-346153-9162w7il 24 4 classi classi NNP cord-346153-9162w7il 24 5 ed ed NNP cord-346153-9162w7il 24 6 genetically genetically RB cord-346153-9162w7il 24 7 into into IN cord-346153-9162w7il 24 8 three three CD cord-346153-9162w7il 24 9 groups group NNS cord-346153-9162w7il 24 10 . . . cord-346153-9162w7il 25 1 One one CD cord-346153-9162w7il 25 2 of of IN cord-346153-9162w7il 25 3 the the DT cord-346153-9162w7il 25 4 group group NN cord-346153-9162w7il 25 5 2 2 CD cord-346153-9162w7il 25 6 viruses virus NNS cord-346153-9162w7il 25 7 , , , cord-346153-9162w7il 25 8 OC43 OC43 NNP cord-346153-9162w7il 25 9 , , , cord-346153-9162w7il 25 10 shows show VBZ cord-346153-9162w7il 25 11 remarkable remarkable JJ cord-346153-9162w7il 25 12 antigenic antigenic JJ cord-346153-9162w7il 25 13 and and CC cord-346153-9162w7il 25 14 genetic genetic JJ cord-346153-9162w7il 25 15 similarities similarity NNS cord-346153-9162w7il 25 16 to to IN cord-346153-9162w7il 25 17 a a DT cord-346153-9162w7il 25 18 common common JJ cord-346153-9162w7il 25 19 bovine bovine JJ cord-346153-9162w7il 25 20 coronavirus coronavirus NN cord-346153-9162w7il 26 1 that that IN cord-346153-9162w7il 26 2 probably probably RB cord-346153-9162w7il 26 3 rst rst VBP cord-346153-9162w7il 26 4 mutated mutate VBN cord-346153-9162w7il 26 5 and and CC cord-346153-9162w7il 26 6 transmitted transmit VBN cord-346153-9162w7il 26 7 to to IN cord-346153-9162w7il 26 8 man man VB cord-346153-9162w7il 26 9 in in IN cord-346153-9162w7il 26 10 the the DT cord-346153-9162w7il 26 11 1890s 1890s CD cord-346153-9162w7il 26 12 . . . cord-346153-9162w7il 27 1 1 1 LS cord-346153-9162w7il 28 1 Although although IN cord-346153-9162w7il 28 2 now now RB cord-346153-9162w7il 28 3 transmitted transmit VBN cord-346153-9162w7il 28 4 from from IN cord-346153-9162w7il 28 5 person person NN cord-346153-9162w7il 28 6 to to IN cord-346153-9162w7il 28 7 person person NN cord-346153-9162w7il 28 8 via via IN cord-346153-9162w7il 28 9 the the DT cord-346153-9162w7il 28 10 respiratory respiratory JJ cord-346153-9162w7il 28 11 tract tract NN cord-346153-9162w7il 28 12 , , , cord-346153-9162w7il 28 13 OC43 OC43 NNP cord-346153-9162w7il 28 14 causes cause VBZ cord-346153-9162w7il 28 15 gastrointestinal gastrointestinal JJ cord-346153-9162w7il 28 16 symptoms symptom NNS cord-346153-9162w7il 28 17 in in IN cord-346153-9162w7il 28 18 up up IN cord-346153-9162w7il 28 19 to to TO cord-346153-9162w7il 28 20 57 57 CD cord-346153-9162w7il 28 21 % % NN cord-346153-9162w7il 28 22 of of IN cord-346153-9162w7il 28 23 infected infected JJ cord-346153-9162w7il 28 24 people people NNS cord-346153-9162w7il 28 25 , , , cord-346153-9162w7il 28 26 along along IN cord-346153-9162w7il 28 27 with with IN cord-346153-9162w7il 28 28 various various JJ cord-346153-9162w7il 28 29 combinations combination NNS cord-346153-9162w7il 28 30 of of IN cord-346153-9162w7il 28 31 rhinitis rhinitis NN cord-346153-9162w7il 28 32 ( ( -LRB- cord-346153-9162w7il 28 33 36.6 36.6 CD cord-346153-9162w7il 28 34 % % NN cord-346153-9162w7il 28 35 ) ) -RRB- cord-346153-9162w7il 28 36 , , , cord-346153-9162w7il 28 37 pharyngitis pharyngitis NN cord-346153-9162w7il 28 38 ( ( -LRB- cord-346153-9162w7il 28 39 30 30 CD cord-346153-9162w7il 28 40 % % NN cord-346153-9162w7il 28 41 ) ) -RRB- cord-346153-9162w7il 28 42 , , , cord-346153-9162w7il 28 43 and and CC cord-346153-9162w7il 28 44 bronchitis bronchitis NN cord-346153-9162w7il 28 45 or or CC cord-346153-9162w7il 28 46 bronchiolitis bronchiolitis NN cord-346153-9162w7il 28 47 ( ( -LRB- cord-346153-9162w7il 28 48 26.6 26.6 CD cord-346153-9162w7il 28 49 % % NN cord-346153-9162w7il 28 50 ) ) -RRB- cord-346153-9162w7il 28 51 . . . cord-346153-9162w7il 29 1 2 2 LS cord-346153-9162w7il 30 1 Therefore therefore RB cord-346153-9162w7il 30 2 , , , cord-346153-9162w7il 30 3 gastrointestinal gastrointestinal JJ cord-346153-9162w7il 30 4 symptoms symptom NNS cord-346153-9162w7il 30 5 can can MD cord-346153-9162w7il 30 6 be be VB cord-346153-9162w7il 30 7 as as RB cord-346153-9162w7il 30 8 prominent prominent JJ cord-346153-9162w7il 30 9 as as IN cord-346153-9162w7il 30 10 respiratory respiratory JJ cord-346153-9162w7il 30 11 symptoms symptom NNS cord-346153-9162w7il 30 12 in in IN cord-346153-9162w7il 30 13 coronavirus coronavirus NN cord-346153-9162w7il 30 14 colds cold NNS cord-346153-9162w7il 30 15 , , , cord-346153-9162w7il 30 16 o o NN cord-346153-9162w7il 30 17 en en NN cord-346153-9162w7il 30 18 labeled label VBN cord-346153-9162w7il 30 19 " " `` cord-346153-9162w7il 30 20 gastric gastric JJ cord-346153-9162w7il 30 21 u u NN cord-346153-9162w7il 30 22 " " '' cord-346153-9162w7il 30 23 . . . cord-346153-9162w7il 31 1 In in IN cord-346153-9162w7il 31 2 veterinary veterinary JJ cord-346153-9162w7il 31 3 practice practice NN cord-346153-9162w7il 31 4 , , , cord-346153-9162w7il 31 5 coronaviruses coronaviruse NNS cord-346153-9162w7il 31 6 are be VBP cord-346153-9162w7il 31 7 also also RB cord-346153-9162w7il 31 8 notorious notorious JJ cord-346153-9162w7il 31 9 for for IN cord-346153-9162w7il 31 10 causing cause VBG cord-346153-9162w7il 31 11 infection infection NN cord-346153-9162w7il 31 12 of of IN cord-346153-9162w7il 31 13 either either CC cord-346153-9162w7il 31 14 the the DT cord-346153-9162w7il 31 15 gut gut NN cord-346153-9162w7il 31 16 or or CC cord-346153-9162w7il 31 17 lung lung NN cord-346153-9162w7il 31 18 and and CC cord-346153-9162w7il 31 19 for for IN cord-346153-9162w7il 31 20 sometimes sometimes RB cord-346153-9162w7il 31 21 moving move VBG cord-346153-9162w7il 31 22 between between IN cord-346153-9162w7il 31 23 sites site NNS cord-346153-9162w7il 31 24 . . . cord-346153-9162w7il 32 1 Porcine porcine JJ cord-346153-9162w7il 32 2 transmissible transmissible JJ cord-346153-9162w7il 32 3 gastroenteritis gastroenteritis NN cord-346153-9162w7il 32 4 virus virus NN cord-346153-9162w7il 32 5 ( ( -LRB- cord-346153-9162w7il 32 6 TGEV TGEV NNP cord-346153-9162w7il 32 7 ) ) -RRB- cord-346153-9162w7il 32 8 is be VBZ cord-346153-9162w7il 32 9 a a DT cord-346153-9162w7il 32 10 coronavirus coronavirus NN cord-346153-9162w7il 32 11 related relate VBN cord-346153-9162w7il 32 12 to to IN cord-346153-9162w7il 32 13 the the DT cord-346153-9162w7il 32 14 229E 229e CD cord-346153-9162w7il 32 15 strain strain NN cord-346153-9162w7il 32 16 of of IN cord-346153-9162w7il 32 17 coronavirus coronavirus NN cord-346153-9162w7il 32 18 ( ( -LRB- cord-346153-9162w7il 32 19 another another DT cord-346153-9162w7il 32 20 cause cause NN cord-346153-9162w7il 32 21 of of IN cord-346153-9162w7il 32 22 common common JJ cord-346153-9162w7il 32 23 colds cold NNS cord-346153-9162w7il 32 24 in in IN cord-346153-9162w7il 32 25 man man NN cord-346153-9162w7il 32 26 ) ) -RRB- cord-346153-9162w7il 32 27 . . . cord-346153-9162w7il 33 1 TGEV TGEV NNP cord-346153-9162w7il 33 2 was be VBD cord-346153-9162w7il 33 3 a a DT cord-346153-9162w7il 33 4 major major JJ cord-346153-9162w7il 33 5 cause cause NN cord-346153-9162w7il 33 6 of of IN cord-346153-9162w7il 33 7 severe severe JJ cord-346153-9162w7il 33 8 gastroenteritis gastroenteritis NN cord-346153-9162w7il 33 9 in in IN cord-346153-9162w7il 33 10 domesticated domesticated JJ cord-346153-9162w7il 33 11 pigs pig NNS cord-346153-9162w7il 33 12 , , , cord-346153-9162w7il 33 13 causing cause VBG cord-346153-9162w7il 33 14 significant significant JJ cord-346153-9162w7il 33 15 morbidity morbidity NN cord-346153-9162w7il 33 16 and and CC cord-346153-9162w7il 33 17 mortality mortality NN cord-346153-9162w7il 33 18 throughout throughout IN cord-346153-9162w7il 33 19 worldwide worldwide RB cord-346153-9162w7il 33 20 . . . cord-346153-9162w7il 34 1 However however RB cord-346153-9162w7il 34 2 , , , cord-346153-9162w7il 34 3 in in IN cord-346153-9162w7il 34 4 1984 1984 CD cord-346153-9162w7il 34 5 spontaneous spontaneous JJ cord-346153-9162w7il 34 6 deletions deletion NNS cord-346153-9162w7il 34 7 caused cause VBD cord-346153-9162w7il 34 8 a a DT cord-346153-9162w7il 34 9 new new JJ cord-346153-9162w7il 34 10 strain strain NN cord-346153-9162w7il 34 11 to to TO cord-346153-9162w7il 34 12 emerge emerge VB cord-346153-9162w7il 34 13 transmitted transmit VBN cord-346153-9162w7il 34 14 via via IN cord-346153-9162w7il 34 15 the the DT cord-346153-9162w7il 34 16 respiratory respiratory JJ cord-346153-9162w7il 34 17 route route NN cord-346153-9162w7il 34 18 and and CC cord-346153-9162w7il 34 19 causing cause VBG cord-346153-9162w7il 34 20 predominately predominately RB cord-346153-9162w7il 34 21 upper upper JJ cord-346153-9162w7il 34 22 respiratory respiratory JJ cord-346153-9162w7il 34 23 symptoms symptom NNS cord-346153-9162w7il 34 24 , , , cord-346153-9162w7il 34 25 and and CC cord-346153-9162w7il 34 26 o o UH cord-346153-9162w7il 34 27 en en NN cord-346153-9162w7il 34 28 mild mild JJ cord-346153-9162w7il 34 29 or or CC cord-346153-9162w7il 34 30 inapparent inapparent JJ cord-346153-9162w7il 34 31 infection infection NN cord-346153-9162w7il 34 32 . . . cord-346153-9162w7il 35 1 is be VBZ cord-346153-9162w7il 35 2 new new JJ cord-346153-9162w7il 35 3 virus virus NN cord-346153-9162w7il 35 4 was be VBD cord-346153-9162w7il 35 5 su su NNP cord-346153-9162w7il 35 6 ciently ciently RB cord-346153-9162w7il 35 7 antigenetically antigenetically RB cord-346153-9162w7il 35 8 similar similar JJ cord-346153-9162w7il 35 9 to to IN cord-346153-9162w7il 35 10 TGEV TGEV NNP cord-346153-9162w7il 35 11 to to TO cord-346153-9162w7il 35 12 cause cause VB cord-346153-9162w7il 35 13 cross cross NN cord-346153-9162w7il 35 14 - - NN cord-346153-9162w7il 35 15 protection protection NN cord-346153-9162w7il 35 16 , , , cord-346153-9162w7il 35 17 3 3 CD cord-346153-9162w7il 35 18 so so IN cord-346153-9162w7il 35 19 that that IN cord-346153-9162w7il 35 20 the the DT cord-346153-9162w7il 35 21 new new JJ cord-346153-9162w7il 35 22 strain strain NN cord-346153-9162w7il 35 23 virtually virtually RB cord-346153-9162w7il 35 24 wiped wipe VBD cord-346153-9162w7il 35 25 out out RP cord-346153-9162w7il 35 26 the the DT cord-346153-9162w7il 35 27 parental parental JJ cord-346153-9162w7il 35 28 strain strain NN cord-346153-9162w7il 35 29 . . . cord-346153-9162w7il 36 1 erefore erefore NNP cord-346153-9162w7il 36 2 , , , cord-346153-9162w7il 36 3 the the DT cord-346153-9162w7il 36 4 respiratory respiratory JJ cord-346153-9162w7il 36 5 version version NN cord-346153-9162w7il 36 6 of of IN cord-346153-9162w7il 36 7 the the DT cord-346153-9162w7il 36 8 coronavirus coronavirus NN cord-346153-9162w7il 36 9 acted act VBD cord-346153-9162w7il 36 10 as as IN cord-346153-9162w7il 36 11 a a DT cord-346153-9162w7il 36 12 natural natural JJ cord-346153-9162w7il 36 13 vaccine vaccine NN cord-346153-9162w7il 36 14 , , , cord-346153-9162w7il 36 15 eliminating eliminate VBG cord-346153-9162w7il 36 16 TGEV TGEV NNP cord-346153-9162w7il 36 17 as as IN cord-346153-9162w7il 36 18 a a DT cord-346153-9162w7il 36 19 signi signi NN cord-346153-9162w7il 36 20 ca can MD cord-346153-9162w7il 36 21 nt not RB cord-346153-9162w7il 36 22 veterinary veterinary JJ cord-346153-9162w7il 36 23 problem problem NN cord-346153-9162w7il 36 24 . . . cord-346153-9162w7il 37 1 Although although IN cord-346153-9162w7il 37 2 known know VBN cord-346153-9162w7il 37 3 as as IN cord-346153-9162w7il 37 4 respiratory respiratory JJ cord-346153-9162w7il 37 5 pathogens pathogen NNS cord-346153-9162w7il 37 6 , , , cord-346153-9162w7il 37 7 severe severe JJ cord-346153-9162w7il 37 8 acute acute JJ cord-346153-9162w7il 37 9 respiratory respiratory JJ cord-346153-9162w7il 37 10 syndrome syndrome NN cord-346153-9162w7il 37 11 ( ( -LRB- cord-346153-9162w7il 37 12 SARS SARS NNP cord-346153-9162w7il 37 13 ) ) -RRB- cord-346153-9162w7il 37 14 and and CC cord-346153-9162w7il 37 15 its -PRON- PRP$ cord-346153-9162w7il 37 16 sister sister NN cord-346153-9162w7il 37 17 coronaviruses coronaviruse NNS cord-346153-9162w7il 37 18 frequently frequently RB cord-346153-9162w7il 37 19 cause cause VBP cord-346153-9162w7il 37 20 enteric enteric JJ cord-346153-9162w7il 37 21 symptoms symptom NNS cord-346153-9162w7il 37 22 . . . cord-346153-9162w7il 38 1 In in IN cord-346153-9162w7il 38 2 addition addition NN cord-346153-9162w7il 38 3 , , , cord-346153-9162w7il 38 4 other other JJ cord-346153-9162w7il 38 5 classically classically RB cord-346153-9162w7il 38 6 non non JJ cord-346153-9162w7il 38 7 - - JJ cord-346153-9162w7il 38 8 enteric enteric JJ cord-346153-9162w7il 38 9 viruses virus NNS cord-346153-9162w7il 38 10 ( ( -LRB- cord-346153-9162w7il 38 11 such such JJ cord-346153-9162w7il 38 12 as as IN cord-346153-9162w7il 38 13 HIV HIV NNP cord-346153-9162w7il 38 14 and and CC cord-346153-9162w7il 38 15 influenza influenza NN cord-346153-9162w7il 38 16 ) ) -RRB- cord-346153-9162w7il 38 17 may may MD cord-346153-9162w7il 38 18 also also RB cord-346153-9162w7il 38 19 have have VB cord-346153-9162w7il 38 20 enteric enteric JJ cord-346153-9162w7il 38 21 effects effect NNS cord-346153-9162w7il 38 22 that that WDT cord-346153-9162w7il 38 23 are be VBP cord-346153-9162w7il 38 24 crucial crucial JJ cord-346153-9162w7il 38 25 in in IN cord-346153-9162w7il 38 26 their -PRON- PRP$ cord-346153-9162w7il 38 27 pathogeneses pathogenese NNS cord-346153-9162w7il 38 28 . . . cord-346153-9162w7il 39 1 These these DT cord-346153-9162w7il 39 2 effects effect NNS cord-346153-9162w7il 39 3 can can MD cord-346153-9162w7il 39 4 be be VB cord-346153-9162w7il 39 5 due due JJ cord-346153-9162w7il 39 6 to to IN cord-346153-9162w7il 39 7 direct direct JJ cord-346153-9162w7il 39 8 infection infection NN cord-346153-9162w7il 39 9 of of IN cord-346153-9162w7il 39 10 the the DT cord-346153-9162w7il 39 11 gut gut NN cord-346153-9162w7il 39 12 mucosa mucosa NN cord-346153-9162w7il 39 13 , , , cord-346153-9162w7il 39 14 but but CC cord-346153-9162w7il 39 15 can can MD cord-346153-9162w7il 39 16 also also RB cord-346153-9162w7il 39 17 be be VB cord-346153-9162w7il 39 18 because because IN cord-346153-9162w7il 39 19 of of IN cord-346153-9162w7il 39 20 decreased decrease VBN cord-346153-9162w7il 39 21 antibacterial antibacterial JJ cord-346153-9162w7il 39 22 defenses defense NNS cord-346153-9162w7il 39 23 , , , cord-346153-9162w7il 39 24 increased increase VBN cord-346153-9162w7il 39 25 mucosal mucosal JJ cord-346153-9162w7il 39 26 permeability permeability NN cord-346153-9162w7il 39 27 , , , cord-346153-9162w7il 39 28 bacterial bacterial JJ cord-346153-9162w7il 39 29 translocation translocation NN cord-346153-9162w7il 39 30 , , , cord-346153-9162w7il 39 31 and and CC cord-346153-9162w7il 39 32 systemic systemic JJ cord-346153-9162w7il 39 33 leak leak NN cord-346153-9162w7il 39 34 of of IN cord-346153-9162w7il 39 35 endotoxin endotoxin NN cord-346153-9162w7il 39 36 . . . cord-346153-9162w7il 40 1 nature nature NNP cord-346153-9162w7il 40 2 publishing publishing NNP cord-346153-9162w7il 40 3 group group NN cord-346153-9162w7il 40 4 COMMENTARIES COMMENTARIES NNP cord-346153-9162w7il 40 5 SARS SARS NNP cord-346153-9162w7il 40 6 was be VBD cord-346153-9162w7il 40 7 characterized characterize VBN cord-346153-9162w7il 40 8 by by IN cord-346153-9162w7il 40 9 intense intense JJ cord-346153-9162w7il 40 10 systemic systemic JJ cord-346153-9162w7il 40 11 symptoms symptom NNS cord-346153-9162w7il 40 12 and and CC cord-346153-9162w7il 40 13 triggering triggering NN cord-346153-9162w7il 40 14 of of IN cord-346153-9162w7il 40 15 exuberant exuberant JJ cord-346153-9162w7il 40 16 host host NN cord-346153-9162w7il 40 17 immune immune JJ cord-346153-9162w7il 40 18 responses response NNS cord-346153-9162w7il 40 19 . . . cord-346153-9162w7il 41 1 5 5 LS cord-346153-9162w7il 42 1 Detailed detailed JJ cord-346153-9162w7il 42 2 pathological pathological JJ cord-346153-9162w7il 42 3 studies study NNS cord-346153-9162w7il 42 4 showed show VBD cord-346153-9162w7il 42 5 that that IN cord-346153-9162w7il 42 6 SARS SARS NNP cord-346153-9162w7il 42 7 coronavirus coronavirus NN cord-346153-9162w7il 42 8 could could MD cord-346153-9162w7il 42 9 infect infect VB cord-346153-9162w7il 42 10 not not RB cord-346153-9162w7il 42 11 only only RB cord-346153-9162w7il 42 12 the the DT cord-346153-9162w7il 42 13 respiratory respiratory JJ cord-346153-9162w7il 42 14 epithelium epithelium NN cord-346153-9162w7il 42 15 , , , cord-346153-9162w7il 42 16 but but CC cord-346153-9162w7il 42 17 also also RB cord-346153-9162w7il 42 18 surface surface VBP cord-346153-9162w7il 42 19 enterocytes enterocyte NNS cord-346153-9162w7il 42 20 in in IN cord-346153-9162w7il 42 21 the the DT cord-346153-9162w7il 42 22 small small JJ cord-346153-9162w7il 42 23 bowel bowel NN cord-346153-9162w7il 42 24 . . . cord-346153-9162w7il 43 1 Although although IN cord-346153-9162w7il 43 2 infection infection NN cord-346153-9162w7il 43 3 caused cause VBD cord-346153-9162w7il 43 4 di di FW cord-346153-9162w7il 43 5 use use VB cord-346153-9162w7il 43 6 alveolar alveolar JJ cord-346153-9162w7il 43 7 damage damage NN cord-346153-9162w7il 43 8 , , , cord-346153-9162w7il 43 9 the the DT cord-346153-9162w7il 43 10 changes change NNS cord-346153-9162w7il 43 11 in in IN cord-346153-9162w7il 43 12 the the DT cord-346153-9162w7il 43 13 gut gut NN cord-346153-9162w7il 43 14 are be VBP cord-346153-9162w7il 43 15 more more RBR cord-346153-9162w7il 43 16 subtle subtle JJ cord-346153-9162w7il 43 17 6 6 CD cord-346153-9162w7il 43 18 and and CC cord-346153-9162w7il 43 19 might may MD cord-346153-9162w7il 43 20 include include VB cord-346153-9162w7il 43 21 an an DT cord-346153-9162w7il 43 22 increase increase NN cord-346153-9162w7il 43 23 in in IN cord-346153-9162w7il 43 24 intestinal intestinal JJ cord-346153-9162w7il 43 25 permeability permeability NN cord-346153-9162w7il 43 26 to to IN cord-346153-9162w7il 43 27 lipopolysaccharide lipopolysaccharide NN cord-346153-9162w7il 43 28 ( ( -LRB- cord-346153-9162w7il 43 29 LPS LPS NNP cord-346153-9162w7il 43 30 ) ) -RRB- cord-346153-9162w7il 43 31 and and CC cord-346153-9162w7il 43 32 transmigration transmigration NN cord-346153-9162w7il 43 33 of of IN cord-346153-9162w7il 43 34 intestinal intestinal JJ cord-346153-9162w7il 43 35 bacteria bacteria NNS cord-346153-9162w7il 43 36 ( ( -LRB- cord-346153-9162w7il 43 37 Figure figure NN cord-346153-9162w7il 43 38 1c 1c CD cord-346153-9162w7il 43 39 ) ) -RRB- cord-346153-9162w7il 43 40 . . . cord-346153-9162w7il 44 1 Remarkably remarkably RB cord-346153-9162w7il 44 2 , , , cord-346153-9162w7il 44 3 the the DT cord-346153-9162w7il 44 4 onset onset NN cord-346153-9162w7il 44 5 of of IN cord-346153-9162w7il 44 6 diarrhea diarrhea NN cord-346153-9162w7il 44 7 in in IN cord-346153-9162w7il 44 8 SARS SARS NNP cord-346153-9162w7il 44 9 infected infect VBD cord-346153-9162w7il 44 10 patients patient NNS cord-346153-9162w7il 44 11 usually usually RB cord-346153-9162w7il 44 12 peaked peak VBD cord-346153-9162w7il 44 13 on on IN cord-346153-9162w7il 44 14 days day NNS cord-346153-9162w7il 44 15 4 4 CD cord-346153-9162w7il 44 16 -9 -9 NNP cord-346153-9162w7il 44 17 , , , cord-346153-9162w7il 44 18 by by IN cord-346153-9162w7il 44 19 which which WDT cord-346153-9162w7il 44 20 time time NN cord-346153-9162w7il 44 21 the the DT cord-346153-9162w7il 44 22 fever fever NN cord-346153-9162w7il 44 23 had have VBD cord-346153-9162w7il 44 24 subsided subside VBN cord-346153-9162w7il 44 25 . . . cord-346153-9162w7il 45 1 However however RB cord-346153-9162w7il 45 2 , , , cord-346153-9162w7il 45 3 the the DT cord-346153-9162w7il 45 4 coronavirus coronavirus NN cord-346153-9162w7il 45 5 copy copy NN cord-346153-9162w7il 45 6 number number NN cord-346153-9162w7il 45 7 in in IN cord-346153-9162w7il 45 8 some some DT cord-346153-9162w7il 45 9 studies study NNS cord-346153-9162w7il 45 10 showed show VBD cord-346153-9162w7il 45 11 an an DT cord-346153-9162w7il 45 12 increase increase NN cord-346153-9162w7il 45 13 between between IN cord-346153-9162w7il 45 14 day day NN cord-346153-9162w7il 45 15 5 5 CD cord-346153-9162w7il 45 16 and and CC cord-346153-9162w7il 45 17 day day NN cord-346153-9162w7il 45 18 10 10 CD cord-346153-9162w7il 45 19 , , , cord-346153-9162w7il 45 20 so so IN cord-346153-9162w7il 45 21 that that IN cord-346153-9162w7il 45 22 maximal maximal JJ cord-346153-9162w7il 45 23 infectivity infectivity NN cord-346153-9162w7il 45 24 followed follow VBD cord-346153-9162w7il 45 25 the the DT cord-346153-9162w7il 45 26 fever fever NN cord-346153-9162w7il 45 27 , , , cord-346153-9162w7il 45 28 7 7 CD cord-346153-9162w7il 45 29 leading lead VBG cord-346153-9162w7il 45 30 perhaps perhaps RB cord-346153-9162w7il 45 31 to to IN cord-346153-9162w7il 45 32 a a DT cord-346153-9162w7il 45 33 false false JJ cord-346153-9162w7il 45 34 sense sense NN cord-346153-9162w7il 45 35 of of IN cord-346153-9162w7il 45 36 security security NN cord-346153-9162w7il 45 37 amongst amongst IN cord-346153-9162w7il 45 38 those those DT cord-346153-9162w7il 45 39 caring care VBG cord-346153-9162w7il 45 40 for for IN cord-346153-9162w7il 45 41 SARS SARS NNP cord-346153-9162w7il 45 42 patients patient NNS cord-346153-9162w7il 45 43 . . . cord-346153-9162w7il 46 1 Although although IN cord-346153-9162w7il 46 2 virus virus NN cord-346153-9162w7il 46 3 copy copy NN cord-346153-9162w7il 46 4 number number NN cord-346153-9162w7il 46 5 in in IN cord-346153-9162w7il 46 6 the the DT cord-346153-9162w7il 46 7 pharyngeal pharyngeal JJ cord-346153-9162w7il 46 8 aspirates aspirate NNS cord-346153-9162w7il 46 9 dropped drop VBD cord-346153-9162w7il 46 10 signi signi NNP cord-346153-9162w7il 46 11 cantly cantly NNP cord-346153-9162w7il 46 12 between between IN cord-346153-9162w7il 46 13 days day NNS cord-346153-9162w7il 46 14 10 10 CD cord-346153-9162w7il 46 15 and and CC cord-346153-9162w7il 46 16 15 15 CD cord-346153-9162w7il 46 17 , , , cord-346153-9162w7il 46 18 many many JJ cord-346153-9162w7il 46 19 patients patient NNS cord-346153-9162w7il 46 20 still still RB cord-346153-9162w7il 46 21 had have VBD cord-346153-9162w7il 46 22 SARS SARS NNP cord-346153-9162w7il 46 23 coronavirus coronavirus NN cord-346153-9162w7il 46 24 present present JJ cord-346153-9162w7il 46 25 in in IN cord-346153-9162w7il 46 26 the the DT cord-346153-9162w7il 46 27 stool stool NN cord-346153-9162w7il 46 28 at at IN cord-346153-9162w7il 46 29 day day NN cord-346153-9162w7il 46 30 21 21 CD cord-346153-9162w7il 46 31 , , , cord-346153-9162w7il 46 32 by by IN cord-346153-9162w7il 46 33 which which WDT cord-346153-9162w7il 46 34 time time NN cord-346153-9162w7il 46 35 under under IN cord-346153-9162w7il 46 36 50 50 CD cord-346153-9162w7il 46 37 % % NN cord-346153-9162w7il 46 38 had have VBD cord-346153-9162w7il 46 39 virus virus NN cord-346153-9162w7il 46 40 present present JJ cord-346153-9162w7il 46 41 in in IN cord-346153-9162w7il 46 42 the the DT cord-346153-9162w7il 46 43 nasopharyngeal nasopharyngeal JJ cord-346153-9162w7il 46 44 aspirate aspirate NN cord-346153-9162w7il 46 45 . . . cord-346153-9162w7il 47 1 erefore erefore NNP cord-346153-9162w7il 47 2 , , , cord-346153-9162w7il 47 3 late late JJ cord-346153-9162w7il 47 4 transmission transmission NN cord-346153-9162w7il 47 5 by by IN cord-346153-9162w7il 47 6 contact contact NN cord-346153-9162w7il 47 7 with with IN cord-346153-9162w7il 47 8 stool stool NN cord-346153-9162w7il 47 9 was be VBD cord-346153-9162w7il 47 10 a a DT cord-346153-9162w7il 47 11 particular particular JJ cord-346153-9162w7il 47 12 unappreciated unappreciated JJ cord-346153-9162w7il 47 13 risk risk NN cord-346153-9162w7il 47 14 . . . cord-346153-9162w7il 48 1 Infection infection NN cord-346153-9162w7il 48 2 with with IN cord-346153-9162w7il 48 3 porcine porcine JJ cord-346153-9162w7il 48 4 respiratory respiratory JJ cord-346153-9162w7il 48 5 coronavirus coronavirus NN cord-346153-9162w7il 48 6 or or CC cord-346153-9162w7il 48 7 porcine porcine JJ cord-346153-9162w7il 48 8 reproductive reproductive JJ cord-346153-9162w7il 48 9 and and CC cord-346153-9162w7il 48 10 respiratory respiratory JJ cord-346153-9162w7il 48 11 syndrome syndrome NN cord-346153-9162w7il 48 12 virus virus NN cord-346153-9162w7il 48 13 has have VBZ cord-346153-9162w7il 48 14 a a DT cord-346153-9162w7il 48 15 synergistic synergistic JJ cord-346153-9162w7il 48 16 e e NN cord-346153-9162w7il 48 17 ect ect FW cord-346153-9162w7il 48 18 with with IN cord-346153-9162w7il 48 19 bacterial bacterial JJ cord-346153-9162w7il 48 20 products product NNS cord-346153-9162w7il 48 21 , , , cord-346153-9162w7il 48 22 demonstrated demonstrate VBN cord-346153-9162w7il 48 23 by by IN cord-346153-9162w7il 48 24 enhanced enhance VBN cord-346153-9162w7il 48 25 in in IN cord-346153-9162w7il 48 26 ammation ammation NN cord-346153-9162w7il 48 27 induced induce VBN cord-346153-9162w7il 48 28 by by IN cord-346153-9162w7il 48 29 LPS LPS NNP cord-346153-9162w7il 48 30 from from IN cord-346153-9162w7il 48 31 Escherichia Escherichia NNP cord-346153-9162w7il 48 32 coli coli NNS cord-346153-9162w7il 48 33 . . . cord-346153-9162w7il 49 1 LPS lp NNS cord-346153-9162w7il 49 2 caused cause VBD cord-346153-9162w7il 49 3 potentiation potentiation NN cord-346153-9162w7il 49 4 of of IN cord-346153-9162w7il 49 5 disease disease NN cord-346153-9162w7il 49 6 , , , cord-346153-9162w7il 49 7 with with IN cord-346153-9162w7il 49 8 enhanced enhanced JJ cord-346153-9162w7il 49 9 production production NN cord-346153-9162w7il 49 10 of of IN cord-346153-9162w7il 49 11 tumor tumor NN cord-346153-9162w7il 49 12 necrosis necrosis NN cord-346153-9162w7il 49 13 factor factor NN cord-346153-9162w7il 49 14 , , , cord-346153-9162w7il 49 15 interleukin-1 interleukin-1 NN cord-346153-9162w7il 49 16 , , , cord-346153-9162w7il 49 17 and and CC cord-346153-9162w7il 49 18 interleukin-6 interleukin-6 NNP cord-346153-9162w7il 49 19 . . . cord-346153-9162w7il 50 1 8 8 CD cord-346153-9162w7il 51 1 It -PRON- PRP cord-346153-9162w7il 51 2 has have VBZ cord-346153-9162w7il 51 3 been be VBN cord-346153-9162w7il 51 4 known know VBN cord-346153-9162w7il 51 5 for for IN cord-346153-9162w7il 51 6 many many JJ cord-346153-9162w7il 51 7 years year NNS cord-346153-9162w7il 51 8 that that IN cord-346153-9162w7il 51 9 healthy healthy JJ cord-346153-9162w7il 51 10 people people NNS cord-346153-9162w7il 52 1 o o UH cord-346153-9162w7il 52 2 en en TO cord-346153-9162w7il 52 3 carry carry VB cord-346153-9162w7il 52 4 pathogenic pathogenic JJ cord-346153-9162w7il 52 5 bacteria bacteria NNS cord-346153-9162w7il 52 6 ( ( -LRB- cord-346153-9162w7il 52 7 such such JJ cord-346153-9162w7il 52 8 as as IN cord-346153-9162w7il 52 9 Neisseria Neisseria NNP cord-346153-9162w7il 52 10 meningitides meningitide NNS cord-346153-9162w7il 52 11 or or CC cord-346153-9162w7il 52 12 Streptococcus Streptococcus NNP cord-346153-9162w7il 52 13 pneumoniae pneumoniae NN cord-346153-9162w7il 52 14 ) ) -RRB- cord-346153-9162w7il 52 15 in in IN cord-346153-9162w7il 52 16 the the DT cord-346153-9162w7il 52 17 upper upper JJ cord-346153-9162w7il 52 18 respiratory respiratory JJ cord-346153-9162w7il 52 19 tract tract NN cord-346153-9162w7il 52 20 , , , cord-346153-9162w7il 52 21 but but CC cord-346153-9162w7il 52 22 may may MD cord-346153-9162w7il 52 23 only only RB cord-346153-9162w7il 52 24 develop develop VB cord-346153-9162w7il 52 25 invasive invasive JJ cord-346153-9162w7il 52 26 disease disease NN cord-346153-9162w7il 52 27 during during IN cord-346153-9162w7il 52 28 coinfection coinfection NN cord-346153-9162w7il 52 29 with with IN cord-346153-9162w7il 52 30 respiratory respiratory JJ cord-346153-9162w7il 52 31 viruses virus NNS cord-346153-9162w7il 52 32 . . . cord-346153-9162w7il 53 1 e e LS cord-346153-9162w7il 53 2 reason reason NN cord-346153-9162w7il 53 3 for for IN cord-346153-9162w7il 53 4 these these DT cord-346153-9162w7il 53 5 interactions interaction NNS cord-346153-9162w7il 53 6 are be VBP cord-346153-9162w7il 53 7 incompletely incompletely RB cord-346153-9162w7il 53 8 understood understand VBN cord-346153-9162w7il 53 9 , , , cord-346153-9162w7il 53 10 but but CC cord-346153-9162w7il 53 11 intriguing intriguing JJ cord-346153-9162w7il 53 12 recent recent JJ cord-346153-9162w7il 53 13 study study NN cord-346153-9162w7il 53 14 show show VBP cord-346153-9162w7il 53 15 that that IN cord-346153-9162w7il 53 16 in in IN cord-346153-9162w7il 53 17 uenza uenza NNP cord-346153-9162w7il 53 18 and and CC cord-346153-9162w7il 53 19 respiratory respiratory JJ cord-346153-9162w7il 53 20 syndrome syndrome NN cord-346153-9162w7il 53 21 virus virus NN cord-346153-9162w7il 53 22 are be VBP cord-346153-9162w7il 53 23 both both DT cord-346153-9162w7il 53 24 capable capable JJ cord-346153-9162w7il 53 25 of of IN cord-346153-9162w7il 53 26 causing cause VBG cord-346153-9162w7il 53 27 a a DT cord-346153-9162w7il 53 28 persistent persistent JJ cord-346153-9162w7il 53 29 inhibition inhibition NN cord-346153-9162w7il 53 30 of of IN cord-346153-9162w7il 53 31 the the DT cord-346153-9162w7il 53 32 innate innate JJ cord-346153-9162w7il 53 33 response response NN cord-346153-9162w7il 53 34 to to IN cord-346153-9162w7il 53 35 bacterial bacterial JJ cord-346153-9162w7il 53 36 superinfection superinfection NN cord-346153-9162w7il 53 37 , , , cord-346153-9162w7il 53 38 and and CC cord-346153-9162w7il 53 39 therefore therefore RB cord-346153-9162w7il 53 40 to to IN cord-346153-9162w7il 53 41 increased increase VBN cord-346153-9162w7il 53 42 bacterial bacterial JJ cord-346153-9162w7il 53 43 replication replication NN cord-346153-9162w7il 53 44 and and CC cord-346153-9162w7il 53 45 disease disease NN cord-346153-9162w7il 53 46 . . . cord-346153-9162w7il 54 1 9 9 CD cord-346153-9162w7il 55 1 Although although IN cord-346153-9162w7il 55 2 dual dual JJ cord-346153-9162w7il 55 3 tropism tropism NN cord-346153-9162w7il 55 4 for for IN cord-346153-9162w7il 55 5 both both CC cord-346153-9162w7il 55 6 the the DT cord-346153-9162w7il 55 7 lung lung NN cord-346153-9162w7il 55 8 and and CC cord-346153-9162w7il 55 9 gut gut NN cord-346153-9162w7il 55 10 may may MD cord-346153-9162w7il 55 11 be be VB cord-346153-9162w7il 55 12 an an DT cord-346153-9162w7il 55 13 obvious obvious JJ cord-346153-9162w7il 55 14 and and CC cord-346153-9162w7il 55 15 clear clear JJ cord-346153-9162w7il 55 16 reason reason NN cord-346153-9162w7il 55 17 to to TO cord-346153-9162w7il 55 18 consider consider VB cord-346153-9162w7il 55 19 the the DT cord-346153-9162w7il 55 20 gut gut NN cord-346153-9162w7il 55 21 in in IN cord-346153-9162w7il 55 22 respiratory respiratory JJ cord-346153-9162w7il 55 23 infection infection NN cord-346153-9162w7il 55 24 , , , cord-346153-9162w7il 55 25 links link NNS cord-346153-9162w7il 55 26 can can MD cord-346153-9162w7il 55 27 also also RB cord-346153-9162w7il 55 28 be be VB cord-346153-9162w7il 55 29 more more RBR cord-346153-9162w7il 55 30 subtle subtle JJ cord-346153-9162w7il 55 31 and and CC cord-346153-9162w7il 55 32 complex complex JJ cord-346153-9162w7il 55 33 . . . cord-346153-9162w7il 56 1 HIV HIV NNP cord-346153-9162w7il 56 2 targets target VBZ cord-346153-9162w7il 56 3 CD4-expressing cd4-expresse VBG cord-346153-9162w7il 56 4 T T NNP cord-346153-9162w7il 56 5 cells cell NNS cord-346153-9162w7il 56 6 and and CC cord-346153-9162w7il 56 7 macrophages macrophage NNS cord-346153-9162w7il 56 8 , , , cord-346153-9162w7il 56 9 thereby thereby RB cord-346153-9162w7il 56 10 leading lead VBG cord-346153-9162w7il 56 11 to to IN cord-346153-9162w7il 56 12 immunosuppression immunosuppression NN cord-346153-9162w7il 56 13 . . . cord-346153-9162w7il 57 1 However however RB cord-346153-9162w7il 57 2 , , , cord-346153-9162w7il 57 3 the the DT cord-346153-9162w7il 57 4 symptoms symptom NNS cord-346153-9162w7il 57 5 of of IN cord-346153-9162w7il 57 6 progressive progressive JJ cord-346153-9162w7il 57 7 HIV HIV NNP cord-346153-9162w7il 57 8 infection infection NN cord-346153-9162w7il 57 9 sometimes sometimes RB cord-346153-9162w7il 57 10 include include VBP cord-346153-9162w7il 57 11 profound profound JJ cord-346153-9162w7il 57 12 weight weight NN cord-346153-9162w7il 57 13 loss loss NN cord-346153-9162w7il 57 14 ( ( -LRB- cord-346153-9162w7il 57 15 " " `` cord-346153-9162w7il 57 16 slim slim JJ cord-346153-9162w7il 57 17 disease disease NN cord-346153-9162w7il 57 18 " " '' cord-346153-9162w7il 57 19 ) ) -RRB- cord-346153-9162w7il 57 20 , , , cord-346153-9162w7il 57 21 and and CC cord-346153-9162w7il 57 22 evidence evidence NN cord-346153-9162w7il 57 23 of of IN cord-346153-9162w7il 57 24 systemic systemic JJ cord-346153-9162w7il 57 25 immune immune JJ cord-346153-9162w7il 57 26 activation activation NN cord-346153-9162w7il 57 27 . . . cord-346153-9162w7il 58 1 Indeed indeed RB cord-346153-9162w7il 58 2 , , , cord-346153-9162w7il 58 3 this this DT cord-346153-9162w7il 58 4 immune immune JJ cord-346153-9162w7il 58 5 activation activation NN cord-346153-9162w7il 58 6 may may MD cord-346153-9162w7il 58 7 assist assist VB cord-346153-9162w7il 58 8 fresh fresh JJ cord-346153-9162w7il 58 9 infection infection NN cord-346153-9162w7il 58 10 by by IN cord-346153-9162w7il 58 11 HIV HIV NNP cord-346153-9162w7il 58 12 of of IN cord-346153-9162w7il 58 13 activated activate VBN cord-346153-9162w7il 58 14 T T NNP cord-346153-9162w7il 58 15 cells cell NNS cord-346153-9162w7il 58 16 , , , cord-346153-9162w7il 58 17 so so IN cord-346153-9162w7il 58 18 enhancing enhance VBG cord-346153-9162w7il 58 19 the the DT cord-346153-9162w7il 58 20 viral viral JJ cord-346153-9162w7il 58 21 life life NN cord-346153-9162w7il 58 22 cycle cycle NN cord-346153-9162w7il 58 23 . . . cord-346153-9162w7il 59 1 e e LS cord-346153-9162w7il 59 2 reasons reason NNS cord-346153-9162w7il 59 3 for for IN cord-346153-9162w7il 59 4 this this DT cord-346153-9162w7il 59 5 immune immune JJ cord-346153-9162w7il 59 6 activation activation NN cord-346153-9162w7il 59 7 seems seem VBZ cord-346153-9162w7il 59 8 to to TO cord-346153-9162w7il 59 9 include include VB cord-346153-9162w7il 59 10 the the DT cord-346153-9162w7il 59 11 fact fact NN cord-346153-9162w7il 59 12 that that IN cord-346153-9162w7il 59 13 HIV HIV NNP cord-346153-9162w7il 59 14 infects infect VBZ cord-346153-9162w7il 59 15 intestinal intestinal JJ cord-346153-9162w7il 59 16 mucosal mucosal JJ cord-346153-9162w7il 59 17 lymphocytes lymphocyte NNS cord-346153-9162w7il 59 18 , , , cord-346153-9162w7il 59 19 including include VBG cord-346153-9162w7il 59 20 those those DT cord-346153-9162w7il 59 21 in in IN cord-346153-9162w7il 59 22 the the DT cord-346153-9162w7il 59 23 Peyer Peyer NNP cord-346153-9162w7il 59 24 ' ' POS cord-346153-9162w7il 59 25 s s NN cord-346153-9162w7il 59 26 patch patch NN cord-346153-9162w7il 59 27 and and CC cord-346153-9162w7il 59 28 especially especially RB cord-346153-9162w7il 59 29 17 17 CD cord-346153-9162w7il 59 30 cells cell NNS cord-346153-9162w7il 59 31 that that WDT cord-346153-9162w7il 59 32 normally normally RB cord-346153-9162w7il 59 33 keep keep VBP cord-346153-9162w7il 59 34 bacteria bacteria NNS cord-346153-9162w7il 59 35 in in IN cord-346153-9162w7il 59 36 check check NN cord-346153-9162w7il 59 37 10 10 CD cord-346153-9162w7il 59 38 ( ( -LRB- cord-346153-9162w7il 59 39 Figure figure NN cord-346153-9162w7il 59 40 1b 1b CD cord-346153-9162w7il 59 41 ) ) -RRB- cord-346153-9162w7il 59 42 . . . cord-346153-9162w7il 60 1 This this DT cord-346153-9162w7il 60 2 leads lead VBZ cord-346153-9162w7il 60 3 to to IN cord-346153-9162w7il 60 4 enhanced enhanced JJ cord-346153-9162w7il 60 5 gastrointestinal gastrointestinal JJ cord-346153-9162w7il 60 6 permeability permeability NN cord-346153-9162w7il 60 7 to to IN cord-346153-9162w7il 60 8 microbial microbial JJ cord-346153-9162w7il 60 9 products product NNS cord-346153-9162w7il 60 10 , , , cord-346153-9162w7il 60 11 causing cause VBG cord-346153-9162w7il 60 12 increased increase VBN cord-346153-9162w7il 60 13 levels level NNS cord-346153-9162w7il 60 14 of of IN cord-346153-9162w7il 60 15 circulating circulate VBG cord-346153-9162w7il 60 16 LPS LPS NNP cord-346153-9162w7il 60 17 , , , cord-346153-9162w7il 60 18 11 11 CD cord-346153-9162w7il 60 19 further further RB cord-346153-9162w7il 60 20 activating activate VBG cord-346153-9162w7il 60 21 the the DT cord-346153-9162w7il 60 22 innate innate JJ cord-346153-9162w7il 60 23 and and CC cord-346153-9162w7il 60 24 adaptive adaptive JJ cord-346153-9162w7il 60 25 immune immune JJ cord-346153-9162w7il 60 26 system system NN cord-346153-9162w7il 60 27 . . . cord-346153-9162w7il 61 1 An an DT cord-346153-9162w7il 61 2 additional additional JJ cord-346153-9162w7il 61 3 intriguing intriguing JJ cord-346153-9162w7il 61 4 possibility possibility NN cord-346153-9162w7il 61 5 is be VBZ cord-346153-9162w7il 61 6 that that IN cord-346153-9162w7il 61 7 the the DT cord-346153-9162w7il 61 8 distribution distribution NN cord-346153-9162w7il 61 9 of of IN cord-346153-9162w7il 61 10 FoxP3 FoxP3 NNP cord-346153-9162w7il 61 11 + + SYM cord-346153-9162w7il 61 12 regulatory regulatory JJ cord-346153-9162w7il 61 13 T t NN cord-346153-9162w7il 61 14 cells cell NNS cord-346153-9162w7il 61 15 is be VBZ cord-346153-9162w7il 61 16 a a DT cord-346153-9162w7il 61 17 ected ecte VBN cord-346153-9162w7il 61 18 by by IN cord-346153-9162w7il 61 19 HIV HIV NNP cord-346153-9162w7il 61 20 infection infection NN cord-346153-9162w7il 61 21 , , , cord-346153-9162w7il 61 22 12 12 CD cord-346153-9162w7il 61 23 and and CC cord-346153-9162w7il 61 24 that that IN cord-346153-9162w7il 61 25 the the DT cord-346153-9162w7il 61 26 balance balance NN cord-346153-9162w7il 61 27 between between IN cord-346153-9162w7il 61 28 proin proin NNP cord-346153-9162w7il 61 29 ammatory ammatory NNP cord-346153-9162w7il 61 30 and and CC cord-346153-9162w7il 61 31 antiviral antiviral JJ cord-346153-9162w7il 61 32 effects effect NNS cord-346153-9162w7il 61 33 is be VBZ cord-346153-9162w7il 61 34 disturbed disturb VBN cord-346153-9162w7il 61 35 13 13 CD cord-346153-9162w7il 61 36 thereby thereby RB cord-346153-9162w7il 61 37 contributing contribute VBG cord-346153-9162w7il 61 38 to to IN cord-346153-9162w7il 61 39 immune immune JJ cord-346153-9162w7il 61 40 activation activation NN cord-346153-9162w7il 61 41 , , , cord-346153-9162w7il 61 42 malaise malaise NN cord-346153-9162w7il 61 43 , , , cord-346153-9162w7il 61 44 and and CC cord-346153-9162w7il 61 45 cachexia cachexia NN cord-346153-9162w7il 61 46 in in IN cord-346153-9162w7il 61 47 HIV HIV NNP cord-346153-9162w7il 61 48 - - HYPH cord-346153-9162w7il 61 49 infected infect VBN cord-346153-9162w7il 61 50 patients patient NNS cord-346153-9162w7il 61 51 . . . cord-346153-9162w7il 62 1 Highly highly RB cord-346153-9162w7il 62 2 pathogenic pathogenic JJ cord-346153-9162w7il 62 3 strains strain NNS cord-346153-9162w7il 62 4 of of IN cord-346153-9162w7il 62 5 in in IN cord-346153-9162w7il 62 6 uenza uenza NNP cord-346153-9162w7il 62 7 also also RB cord-346153-9162w7il 62 8 cause cause VBP cord-346153-9162w7il 62 9 intense intense JJ cord-346153-9162w7il 62 10 systemic systemic JJ cord-346153-9162w7il 62 11 symptoms symptom NNS cord-346153-9162w7il 62 12 , , , cord-346153-9162w7il 62 13 sometimes sometimes RB cord-346153-9162w7il 62 14 associated associate VBN cord-346153-9162w7il 62 15 with with IN cord-346153-9162w7il 62 16 gastrointestinal gastrointestinal JJ cord-346153-9162w7il 62 17 disease disease NN cord-346153-9162w7il 62 18 . . . cord-346153-9162w7il 63 1 In in IN cord-346153-9162w7il 63 2 waterfowl waterfowl NNS cord-346153-9162w7il 63 3 , , , cord-346153-9162w7il 63 4 in in IN cord-346153-9162w7il 63 5 uenza uenza NNP cord-346153-9162w7il 63 6 is be VBZ cord-346153-9162w7il 63 7 mostly mostly RB cord-346153-9162w7il 63 8 an an DT cord-346153-9162w7il 63 9 enteric enteric JJ cord-346153-9162w7il 63 10 pathogen pathogen NN cord-346153-9162w7il 63 11 , , , cord-346153-9162w7il 63 12 transmitted transmit VBN cord-346153-9162w7il 63 13 via via IN cord-346153-9162w7il 63 14 the the DT cord-346153-9162w7il 63 15 feces fece NNS cord-346153-9162w7il 63 16 in in IN cord-346153-9162w7il 63 17 the the DT cord-346153-9162w7il 63 18 lakes lake NNS cord-346153-9162w7il 63 19 and and CC cord-346153-9162w7il 63 20 waterways waterway NNS cord-346153-9162w7il 63 21 , , , cord-346153-9162w7il 63 22 and and CC cord-346153-9162w7il 63 23 e e LS cord-346153-9162w7il 63 24 ciently ciently RB cord-346153-9162w7il 63 25 transmitted transmit VBN cord-346153-9162w7il 63 26 to to IN cord-346153-9162w7il 63 27 other other JJ cord-346153-9162w7il 63 28 birds bird NNS cord-346153-9162w7il 63 29 feeding feed VBG cord-346153-9162w7il 63 30 and and CC cord-346153-9162w7il 63 31 breeding breed VBG cord-346153-9162w7il 63 32 on on IN cord-346153-9162w7il 63 33 the the DT cord-346153-9162w7il 63 34 same same JJ cord-346153-9162w7il 63 35 water water NN cord-346153-9162w7il 63 36 . . . cord-346153-9162w7il 64 1 When when WRB cord-346153-9162w7il 64 2 these these DT cord-346153-9162w7il 64 3 viruses virus NNS cord-346153-9162w7il 64 4 spread spread VBP cord-346153-9162w7il 64 5 to to IN cord-346153-9162w7il 64 6 man man NN cord-346153-9162w7il 64 7 , , , cord-346153-9162w7il 64 8 viral viral JJ cord-346153-9162w7il 64 9 replication replication NN cord-346153-9162w7il 64 10 can can MD cord-346153-9162w7il 64 11 trigger trigger VB cord-346153-9162w7il 64 12 hypercytokinaemia hypercytokinaemia NN cord-346153-9162w7il 64 13 . . . cord-346153-9162w7il 65 1 14 14 CD cord-346153-9162w7il 66 1 It -PRON- PRP cord-346153-9162w7il 66 2 therefore therefore RB cord-346153-9162w7il 66 3 seems seem VBZ cord-346153-9162w7il 66 4 possible possible JJ cord-346153-9162w7il 66 5 that that IN cord-346153-9162w7il 66 6 the the DT cord-346153-9162w7il 66 7 gut gut NN cord-346153-9162w7il 66 8 ( ( -LRB- cord-346153-9162w7il 66 9 known know VBN cord-346153-9162w7il 66 10 to to TO cord-346153-9162w7il 66 11 be be VB cord-346153-9162w7il 66 12 susceptible susceptible JJ cord-346153-9162w7il 66 13 to to IN cord-346153-9162w7il 66 14 infection infection NN cord-346153-9162w7il 66 15 with with IN cord-346153-9162w7il 66 16 highly highly RB cord-346153-9162w7il 66 17 pathogenic pathogenic JJ cord-346153-9162w7il 66 18 strains strain NNS cord-346153-9162w7il 66 19 of of IN cord-346153-9162w7il 66 20 in in IN cord-346153-9162w7il 66 21 uenza uenza NNP cord-346153-9162w7il 66 22 ) ) -RRB- cord-346153-9162w7il 66 23 15 15 CD cord-346153-9162w7il 66 24 might may MD cord-346153-9162w7il 66 25 also also RB cord-346153-9162w7il 66 26 become become VB cord-346153-9162w7il 66 27 permeable permeable JJ cord-346153-9162w7il 66 28 to to TO cord-346153-9162w7il 66 29 intestinal intestinal JJ cord-346153-9162w7il 66 30 LPS lp NNS cord-346153-9162w7il 66 31 in in IN cord-346153-9162w7il 66 32 severe severe JJ cord-346153-9162w7il 66 33 in in IN cord-346153-9162w7il 66 34 uenza uenza JJ cord-346153-9162w7il 66 35 infections infection NNS cord-346153-9162w7il 66 36 ( ( -LRB- cord-346153-9162w7il 66 37 Figure figure NN cord-346153-9162w7il 66 38 1c 1c CD cord-346153-9162w7il 66 39 ) ) -RRB- cord-346153-9162w7il 66 40 , , , cord-346153-9162w7il 66 41 or or CC cord-346153-9162w7il 66 42 that that IN cord-346153-9162w7il 66 43 bacterial bacterial JJ cord-346153-9162w7il 66 44 translocation translocation NN cord-346153-9162w7il 66 45 through through IN cord-346153-9162w7il 66 46 the the DT cord-346153-9162w7il 66 47 gut gut NN cord-346153-9162w7il 66 48 wall wall NN cord-346153-9162w7il 66 49 could could MD cord-346153-9162w7il 66 50 contribute contribute VB cord-346153-9162w7il 66 51 to to IN cord-346153-9162w7il 66 52 systemic systemic JJ cord-346153-9162w7il 66 53 symptoms symptom NNS cord-346153-9162w7il 66 54 , , , cord-346153-9162w7il 66 55 cytokine cytokine NN cord-346153-9162w7il 66 56 release release NN cord-346153-9162w7il 66 57 and and CC cord-346153-9162w7il 66 58 circulatory circulatory JJ cord-346153-9162w7il 66 59 collapse collapse NN cord-346153-9162w7il 66 60 . . . cord-346153-9162w7il 67 1 In in IN cord-346153-9162w7il 67 2 the the DT cord-346153-9162w7il 67 3 era era NN cord-346153-9162w7il 67 4 of of IN cord-346153-9162w7il 67 5 integrative integrative JJ cord-346153-9162w7il 67 6 systems system NNS cord-346153-9162w7il 67 7 biology biology NN cord-346153-9162w7il 67 8 and and CC cord-346153-9162w7il 67 9 holistic holistic JJ cord-346153-9162w7il 67 10 medicine medicine NN cord-346153-9162w7il 67 11 , , , cord-346153-9162w7il 67 12 it -PRON- PRP cord-346153-9162w7il 67 13 is be VBZ cord-346153-9162w7il 67 14 not not RB cord-346153-9162w7il 67 15 only only RB cord-346153-9162w7il 67 16 timely timely JJ cord-346153-9162w7il 67 17 but but CC cord-346153-9162w7il 67 18 also also RB cord-346153-9162w7il 67 19 essential essential JJ cord-346153-9162w7il 67 20 to to TO cord-346153-9162w7il 67 21 view view VB cord-346153-9162w7il 67 22 the the DT cord-346153-9162w7il 67 23 gut gut NN cord-346153-9162w7il 67 24 and and CC cord-346153-9162w7il 67 25 the the DT cord-346153-9162w7il 67 26 lung lung NN cord-346153-9162w7il 67 27 as as IN cord-346153-9162w7il 67 28 a a DT cord-346153-9162w7il 67 29 continuous continuous JJ cord-346153-9162w7il 67 30 surface surface NN cord-346153-9162w7il 67 31 with with IN cord-346153-9162w7il 67 32 distinct distinct JJ cord-346153-9162w7il 67 33 but but CC cord-346153-9162w7il 67 34 overlapping overlapping JJ cord-346153-9162w7il 67 35 susceptibilities susceptibility NNS cord-346153-9162w7il 67 36 . . . cord-346153-9162w7il 68 1 In in IN cord-346153-9162w7il 68 2 addition addition NN cord-346153-9162w7il 68 3 , , , cord-346153-9162w7il 68 4 viral viral JJ cord-346153-9162w7il 68 5 and and CC cord-346153-9162w7il 68 6 bacterial bacterial JJ cord-346153-9162w7il 68 7 infections infection NNS cord-346153-9162w7il 68 8 should should MD cord-346153-9162w7il 68 9 not not RB cord-346153-9162w7il 68 10 be be VB cord-346153-9162w7il 68 11 regarded regard VBN cord-346153-9162w7il 68 12 as as IN cord-346153-9162w7il 68 13 isolated isolated JJ cord-346153-9162w7il 68 14 events event NNS cord-346153-9162w7il 68 15 but but CC cord-346153-9162w7il 68 16 viewed view VBN cord-346153-9162w7il 68 17 both both CC cord-346153-9162w7il 68 18 in in IN cord-346153-9162w7il 68 19 the the DT cord-346153-9162w7il 68 20 context context NN cord-346153-9162w7il 68 21 of of IN cord-346153-9162w7il 68 22 intercurrent intercurrent NN cord-346153-9162w7il 68 23 infection infection NN cord-346153-9162w7il 68 24 and and CC cord-346153-9162w7il 68 25 of of IN cord-346153-9162w7il 68 26 previous previous JJ cord-346153-9162w7il 68 27 infection infection NN cord-346153-9162w7il 68 28 history history NN cord-346153-9162w7il 68 29 . . . cord-346153-9162w7il 69 1 Studies study NNS cord-346153-9162w7il 69 2 of of IN cord-346153-9162w7il 69 3 single single JJ cord-346153-9162w7il 69 4 infections infection NNS cord-346153-9162w7il 69 5 are be VBP cord-346153-9162w7il 69 6 certainly certainly RB cord-346153-9162w7il 69 7 revealing reveal VBG cord-346153-9162w7il 69 8 , , , cord-346153-9162w7il 69 9 but but CC cord-346153-9162w7il 69 10 in in IN cord-346153-9162w7il 69 11 reality reality NN cord-346153-9162w7il 69 12 the the DT cord-346153-9162w7il 69 13 secret secret NN cord-346153-9162w7il 69 14 to to IN cord-346153-9162w7il 69 15 understanding understanding NN cord-346153-9162w7il 69 16 variations variation NNS cord-346153-9162w7il 69 17 in in IN cord-346153-9162w7il 69 18 responses response NNS cord-346153-9162w7il 69 19 to to IN cord-346153-9162w7il 69 20 infections infection NNS cord-346153-9162w7il 69 21 must must MD cord-346153-9162w7il 69 22 include include VB cord-346153-9162w7il 69 23 an an DT cord-346153-9162w7il 69 24 awareness awareness NN cord-346153-9162w7il 69 25 of of IN cord-346153-9162w7il 69 26 what what WP cord-346153-9162w7il 69 27 else else RB cord-346153-9162w7il 69 28 is be VBZ cord-346153-9162w7il 69 29 present present JJ cord-346153-9162w7il 69 30 on on IN cord-346153-9162w7il 69 31 a a DT cord-346153-9162w7il 69 32 rich rich JJ cord-346153-9162w7il 69 33 polymicrobial polymicrobial JJ cord-346153-9162w7il 69 34 landscape landscape NN cord-346153-9162w7il 69 35 . . . cord-346153-9162w7il 70 1 The the DT cord-346153-9162w7il 70 2 author author NN cord-346153-9162w7il 70 3 declared declare VBD cord-346153-9162w7il 70 4 no no DT cord-346153-9162w7il 70 5 conflict conflict NN cord-346153-9162w7il 70 6 of of IN cord-346153-9162w7il 70 7 interest interest NN cord-346153-9162w7il 70 8 . . . cord-346153-9162w7il 71 1 Complete complete JJ cord-346153-9162w7il 71 2 genomic genomic JJ cord-346153-9162w7il 71 3 sequence sequence NN cord-346153-9162w7il 71 4 of of IN cord-346153-9162w7il 71 5 human human JJ cord-346153-9162w7il 71 6 coronavirus coronavirus NN cord-346153-9162w7il 71 7 OC43 OC43 NNP cord-346153-9162w7il 71 8 : : : cord-346153-9162w7il 71 9 molecular molecular JJ cord-346153-9162w7il 71 10 clock clock NN cord-346153-9162w7il 71 11 analysis analysis NN cord-346153-9162w7il 71 12 suggests suggest VBZ cord-346153-9162w7il 71 13 a a DT cord-346153-9162w7il 71 14 relatively relatively RB cord-346153-9162w7il 71 15 recent recent JJ cord-346153-9162w7il 71 16 zoonotic zoonotic JJ cord-346153-9162w7il 71 17 coronavirus coronavirus NN cord-346153-9162w7il 71 18 transmission transmission NN cord-346153-9162w7il 71 19 event event NN cord-346153-9162w7il 71 20 Detection detection NN cord-346153-9162w7il 71 21 of of IN cord-346153-9162w7il 71 22 respiratory respiratory JJ cord-346153-9162w7il 71 23 syncytial syncytial JJ cord-346153-9162w7il 71 24 virus virus NN cord-346153-9162w7il 71 25 , , , cord-346153-9162w7il 71 26 parainfl parainfl NNP cord-346153-9162w7il 71 27 uenzavirus uenzavirus NNP cord-346153-9162w7il 71 28 3 3 CD cord-346153-9162w7il 71 29 , , , cord-346153-9162w7il 71 30 adenovirus adenovirus NN cord-346153-9162w7il 71 31 and and CC cord-346153-9162w7il 71 32 rhinovirus rhinovirus NN cord-346153-9162w7il 71 33 sequences sequence NNS cord-346153-9162w7il 71 34 in in IN cord-346153-9162w7il 71 35 respiratory respiratory JJ cord-346153-9162w7il 71 36 tract tract NN cord-346153-9162w7il 71 37 of of IN cord-346153-9162w7il 71 38 infants infant NNS cord-346153-9162w7il 71 39 by by IN cord-346153-9162w7il 71 40 polymerase polymerase NN cord-346153-9162w7il 71 41 chain chain NN cord-346153-9162w7il 71 42 reaction reaction NN cord-346153-9162w7il 71 43 and and CC cord-346153-9162w7il 71 44 hybridization hybridization NN cord-346153-9162w7il 71 45 Contribution Contribution NNP cord-346153-9162w7il 71 46 of of IN cord-346153-9162w7il 71 47 antibody antibody NN cord-346153-9162w7il 71 48 - - HYPH cord-346153-9162w7il 71 49 secreting secrete VBG cord-346153-9162w7il 71 50 cells cell NNS cord-346153-9162w7il 71 51 induced induce VBN cord-346153-9162w7il 71 52 in in IN cord-346153-9162w7il 71 53 mucosal mucosal JJ cord-346153-9162w7il 71 54 lymphoid lymphoid JJ cord-346153-9162w7il 71 55 tissues tissue NNS cord-346153-9162w7il 71 56 of of IN cord-346153-9162w7il 71 57 pigs pig NNS cord-346153-9162w7il 71 58 inoculated inoculate VBN cord-346153-9162w7il 71 59 with with IN cord-346153-9162w7il 71 60 respiratory respiratory JJ cord-346153-9162w7il 71 61 or or CC cord-346153-9162w7il 71 62 enteric enteric JJ cord-346153-9162w7il 71 63 strains strain NNS cord-346153-9162w7il 71 64 of of IN cord-346153-9162w7il 71 65 coronavirus coronavirus NN cord-346153-9162w7il 71 66 to to IN cord-346153-9162w7il 71 67 immunity immunity NN cord-346153-9162w7il 71 68 against against IN cord-346153-9162w7il 71 69 enteric enteric JJ cord-346153-9162w7il 71 70 coronavirus coronavirus NN cord-346153-9162w7il 71 71 challenge challenge VB cord-346153-9162w7il 71 72 Evolutionary evolutionary JJ cord-346153-9162w7il 71 73 insights insight NNS cord-346153-9162w7il 71 74 into into IN cord-346153-9162w7il 71 75 the the DT cord-346153-9162w7il 71 76 ecology ecology NN cord-346153-9162w7il 71 77 of of IN cord-346153-9162w7il 71 78 coronaviruses coronaviruse NNS cord-346153-9162w7il 71 79 T T NNP cord-346153-9162w7il 71 80 cell cell NN cord-346153-9162w7il 71 81 responses response NNS cord-346153-9162w7il 71 82 to to IN cord-346153-9162w7il 71 83 whole whole JJ cord-346153-9162w7il 71 84 SARS SARS NNP cord-346153-9162w7il 71 85 coronavirus coronavirus NN cord-346153-9162w7il 71 86 in in IN cord-346153-9162w7il 71 87 humans human NNS cord-346153-9162w7il 71 88 Tissue tissue NN cord-346153-9162w7il 71 89 and and CC cord-346153-9162w7il 71 90 cellular cellular JJ cord-346153-9162w7il 71 91 tropism tropism NN cord-346153-9162w7il 71 92 of of IN cord-346153-9162w7il 71 93 the the DT cord-346153-9162w7il 71 94 coronavirus coronavirus NN cord-346153-9162w7il 71 95 associated associate VBN cord-346153-9162w7il 71 96 with with IN cord-346153-9162w7il 71 97 severe severe JJ cord-346153-9162w7il 71 98 acute acute JJ cord-346153-9162w7il 71 99 respiratory respiratory JJ cord-346153-9162w7il 71 100 syndrome syndrome NN cord-346153-9162w7il 71 101 : : : cord-346153-9162w7il 71 102 an an DT cord-346153-9162w7il 71 103 in in IN cord-346153-9162w7il 71 104 - - HYPH cord-346153-9162w7il 71 105 situ situ NN cord-346153-9162w7il 71 106 hybridization hybridization NN cord-346153-9162w7il 71 107 study study NN cord-346153-9162w7il 71 108 of of IN cord-346153-9162w7il 71 109 fatal fatal JJ cord-346153-9162w7il 71 110 cases case NNS cord-346153-9162w7il 71 111 Clinical clinical JJ cord-346153-9162w7il 71 112 progression progression NN cord-346153-9162w7il 71 113 and and CC cord-346153-9162w7il 71 114 viral viral JJ cord-346153-9162w7il 71 115 load load NN cord-346153-9162w7il 71 116 in in IN cord-346153-9162w7il 71 117 a a DT cord-346153-9162w7il 71 118 community community NN cord-346153-9162w7il 71 119 outbreak outbreak NN cord-346153-9162w7il 71 120 of of IN cord-346153-9162w7il 71 121 coronavirusassociated coronavirusassociate VBN cord-346153-9162w7il 71 122 SARS SARS NNP cord-346153-9162w7il 71 123 pneumonia pneumonia NN cord-346153-9162w7il 71 124 : : : cord-346153-9162w7il 71 125 a a DT cord-346153-9162w7il 71 126 prospective prospective JJ cord-346153-9162w7il 71 127 study study NN cord-346153-9162w7il 71 128 In in IN cord-346153-9162w7il 71 129 vivo vivo NNP cord-346153-9162w7il 71 130 studies study NNS cord-346153-9162w7il 71 131 on on IN cord-346153-9162w7il 71 132 cytokine cytokine JJ cord-346153-9162w7il 71 133 involvement involvement NN cord-346153-9162w7il 71 134 during during IN cord-346153-9162w7il 71 135 acute acute JJ cord-346153-9162w7il 71 136 viral viral JJ cord-346153-9162w7il 71 137 respiratory respiratory JJ cord-346153-9162w7il 71 138 disease disease NN cord-346153-9162w7il 71 139 of of IN cord-346153-9162w7il 71 140 swine swine NN cord-346153-9162w7il 71 141 : : : cord-346153-9162w7il 71 142 troublesome troublesome JJ cord-346153-9162w7il 71 143 but but CC cord-346153-9162w7il 71 144 rewarding rewarding JJ cord-346153-9162w7il 71 145 Sustained sustained JJ cord-346153-9162w7il 71 146 desensitization desensitization NN cord-346153-9162w7il 71 147 to to IN cord-346153-9162w7il 71 148 bacterial bacterial JJ cord-346153-9162w7il 71 149 Toll Toll NNP cord-346153-9162w7il 71 150 - - HYPH cord-346153-9162w7il 71 151 like like JJ cord-346153-9162w7il 71 152 receptor receptor NN cord-346153-9162w7il 71 153 ligands ligand NNS cord-346153-9162w7il 71 154 after after IN cord-346153-9162w7il 71 155 resolution resolution NN cord-346153-9162w7il 71 156 of of IN cord-346153-9162w7il 71 157 respiratory respiratory JJ cord-346153-9162w7il 71 158 infl infl NN cord-346153-9162w7il 71 159 uenza uenza NN cord-346153-9162w7il 71 160 infection infection NN cord-346153-9162w7il 71 161 Differential differential NN cord-346153-9162w7il 72 1 Th17 Th17 NNP cord-346153-9162w7il 73 1 CD4 CD4 NNP cord-346153-9162w7il 73 2 Tcell Tcell NNP cord-346153-9162w7il 73 3 depletion depletion NN cord-346153-9162w7il 73 4 in in IN cord-346153-9162w7il 73 5 pathogenic pathogenic JJ cord-346153-9162w7il 73 6 and and CC cord-346153-9162w7il 73 7 nonpathogenic nonpathogenic JJ cord-346153-9162w7il 73 8 lentiviral lentiviral NNP cord-346153-9162w7il 73 9 infections infection NNS cord-346153-9162w7il 73 10 Microbial microbial JJ cord-346153-9162w7il 73 11 translocation translocation NN cord-346153-9162w7il 73 12 is be VBZ cord-346153-9162w7il 73 13 a a DT cord-346153-9162w7il 73 14 cause cause NN cord-346153-9162w7il 73 15 of of IN cord-346153-9162w7il 73 16 systemic systemic JJ cord-346153-9162w7il 73 17 immune immune JJ cord-346153-9162w7il 73 18 activation activation NN cord-346153-9162w7il 73 19 in in IN cord-346153-9162w7il 73 20 chronic chronic JJ cord-346153-9162w7il 73 21 HIV HIV NNP cord-346153-9162w7il 73 22 infection infection NN cord-346153-9162w7il 73 23 Preservation Preservation NNP cord-346153-9162w7il 73 24 of of IN cord-346153-9162w7il 73 25 FoxP3 FoxP3 NNP cord-346153-9162w7il 73 26 + + SYM cord-346153-9162w7il 73 27 regulatory regulatory JJ cord-346153-9162w7il 73 28 T t NN cord-346153-9162w7il 73 29 cells cell NNS cord-346153-9162w7il 73 30 in in IN cord-346153-9162w7il 73 31 the the DT cord-346153-9162w7il 73 32 peripheral peripheral JJ cord-346153-9162w7il 73 33 blood blood NN cord-346153-9162w7il 73 34 of of IN cord-346153-9162w7il 73 35 human human JJ cord-346153-9162w7il 73 36 immunodefi immunodefi NNP cord-346153-9162w7il 73 37 ciency ciency NNP cord-346153-9162w7il 73 38 virus virus NN cord-346153-9162w7il 73 39 type type NN cord-346153-9162w7il 73 40 1-infected 1-infected CD cord-346153-9162w7il 73 41 elite elite JJ cord-346153-9162w7il 73 42 suppressors suppressor NNS cord-346153-9162w7il 73 43 correlates correlate VBZ cord-346153-9162w7il 73 44 with with IN cord-346153-9162w7il 73 45 low low JJ cord-346153-9162w7il 73 46 CD4 CD4 NNP cord-346153-9162w7il 73 47 + + CC cord-346153-9162w7il 73 48 Tcell Tcell NNP cord-346153-9162w7il 73 49 activation activation NN cord-346153-9162w7il 73 50 Coordination Coordination NNP cord-346153-9162w7il 73 51 of of IN cord-346153-9162w7il 73 52 early early JJ cord-346153-9162w7il 73 53 protective protective JJ cord-346153-9162w7il 73 54 immunity immunity NN cord-346153-9162w7il 73 55 to to IN cord-346153-9162w7il 73 56 viral viral JJ cord-346153-9162w7il 73 57 infection infection NN cord-346153-9162w7il 73 58 by by IN cord-346153-9162w7il 73 59 regulatory regulatory JJ cord-346153-9162w7il 73 60 T t NN cord-346153-9162w7il 73 61 cells cell NNS cord-346153-9162w7il 73 62 Fatal fatal JJ cord-346153-9162w7il 73 63 outcome outcome NN cord-346153-9162w7il 73 64 of of IN cord-346153-9162w7il 73 65 human human JJ cord-346153-9162w7il 73 66 infl infl NN cord-346153-9162w7il 73 67 uenza uenza NNP cord-346153-9162w7il 73 68 A A NNP cord-346153-9162w7il 73 69 ( ( -LRB- cord-346153-9162w7il 73 70 H5N1 H5N1 NNP cord-346153-9162w7il 73 71 ) ) -RRB- cord-346153-9162w7il 73 72 is be VBZ cord-346153-9162w7il 73 73 associated associate VBN cord-346153-9162w7il 73 74 with with IN cord-346153-9162w7il 73 75 high high JJ cord-346153-9162w7il 73 76 viral viral JJ cord-346153-9162w7il 73 77 load load NN cord-346153-9162w7il 73 78 and and CC cord-346153-9162w7il 73 79 hypercytokinemia hypercytokinemia NN cord-346153-9162w7il 73 80 Infl Infl NNP cord-346153-9162w7il 73 81 uenza uenza NNP cord-346153-9162w7il 74 1 A a DT cord-346153-9162w7il 74 2 H5N1 H5N1 NNP cord-346153-9162w7il 74 3 replication replication NN cord-346153-9162w7il 74 4 sites site NNS cord-346153-9162w7il 74 5 in in IN cord-346153-9162w7il 74 6 humans human NNS