id	sid	tid	token	lemma	pos
cord-342936-43u7afl3	1	1	key	key	JJ
cord-342936-43u7afl3	1	2	:	:	:
cord-342936-43u7afl3	1	3	cord-342936	cord-342936	XX
cord-342936-43u7afl3	1	4	-	-	HYPH
cord-342936-43u7afl3	1	5	43u7afl3	43u7afl3	CD
cord-342936-43u7afl3	1	6	authors	author	NNS
cord-342936-43u7afl3	1	7	:	:	:
cord-342936-43u7afl3	1	8	Balzarini	Balzarini	NNP
cord-342936-43u7afl3	1	9	,	,	,
cord-342936-43u7afl3	1	10	Jan	Jan	NNP
cord-342936-43u7afl3	1	11	title	title	NN
cord-342936-43u7afl3	1	12	:	:	:
cord-342936-43u7afl3	1	13	Targeting	target	VBG
cord-342936-43u7afl3	1	14	the	the	DT
cord-342936-43u7afl3	1	15	glycans	glycan	NNS
cord-342936-43u7afl3	1	16	of	of	IN
cord-342936-43u7afl3	1	17	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	1	18	:	:	:
cord-342936-43u7afl3	1	19	a	a	DT
cord-342936-43u7afl3	1	20	novel	novel	JJ
cord-342936-43u7afl3	1	21	paradigm	paradigm	NN
cord-342936-43u7afl3	1	22	for	for	IN
cord-342936-43u7afl3	1	23	antiviral	antiviral	JJ
cord-342936-43u7afl3	1	24	therapy	therapy	NN
cord-342936-43u7afl3	1	25	date	date	NN
cord-342936-43u7afl3	1	26	:	:	:
cord-342936-43u7afl3	1	27	2007	2007	CD
cord-342936-43u7afl3	1	28	journal	journal	NNP
cord-342936-43u7afl3	1	29	:	:	:
cord-342936-43u7afl3	2	1	Nat	Nat	NNP
cord-342936-43u7afl3	2	2	Rev	Rev	NNP
cord-342936-43u7afl3	2	3	Microbiol	Microbiol	NNP
cord-342936-43u7afl3	2	4	DOI	DOI	NNP
cord-342936-43u7afl3	2	5	:	:	:
cord-342936-43u7afl3	3	1	10.1038	10.1038	CD
cord-342936-43u7afl3	3	2	/	/	SYM
cord-342936-43u7afl3	3	3	nrmicro1707	nrmicro1707	XX
cord-342936-43u7afl3	4	1	sha	sha	NNP
cord-342936-43u7afl3	4	2	:	:	:
cord-342936-43u7afl3	5	1	caf698c5b12ce13a26499ad4825c2a8efd8587af	caf698c5b12ce13a26499ad4825c2a8efd8587af	NNP
cord-342936-43u7afl3	5	2	doc_id	doc_id	CD
cord-342936-43u7afl3	5	3	:	:	:
cord-342936-43u7afl3	5	4	342936	342936	CD
cord-342936-43u7afl3	5	5	cord_uid	cord_uid	NNS
cord-342936-43u7afl3	5	6	:	:	:
cord-342936-43u7afl3	6	1	43u7afl3	43u7afl3	CD
cord-342936-43u7afl3	6	2	Several	several	JJ
cord-342936-43u7afl3	6	3	chronic	chronic	JJ
cord-342936-43u7afl3	6	4	viral	viral	JJ
cord-342936-43u7afl3	6	5	infections	infection	NNS
cord-342936-43u7afl3	6	6	(	(	-LRB-
cord-342936-43u7afl3	6	7	such	such	JJ
cord-342936-43u7afl3	6	8	as	as	IN
cord-342936-43u7afl3	6	9	HIV	HIV	NNP
cord-342936-43u7afl3	6	10	and	and	CC
cord-342936-43u7afl3	6	11	hepatitis	hepatitis	NNP
cord-342936-43u7afl3	6	12	C	C	NNP
cord-342936-43u7afl3	6	13	virus	virus	NN
cord-342936-43u7afl3	6	14	)	)	-RRB-
cord-342936-43u7afl3	6	15	are	be	VBP
cord-342936-43u7afl3	6	16	highly	highly	RB
cord-342936-43u7afl3	6	17	prevalent	prevalent	JJ
cord-342936-43u7afl3	6	18	and	and	CC
cord-342936-43u7afl3	6	19	are	be	VBP
cord-342936-43u7afl3	6	20	a	a	DT
cord-342936-43u7afl3	6	21	serious	serious	JJ
cord-342936-43u7afl3	6	22	health	health	NN
cord-342936-43u7afl3	6	23	risk	risk	NN
cord-342936-43u7afl3	6	24	.	.	.
cord-342936-43u7afl3	7	1	The	the	DT
cord-342936-43u7afl3	7	2	adaptation	adaptation	NN
cord-342936-43u7afl3	7	3	of	of	IN
cord-342936-43u7afl3	7	4	animal	animal	NN
cord-342936-43u7afl3	7	5	viruses	virus	NNS
cord-342936-43u7afl3	7	6	to	to	IN
cord-342936-43u7afl3	7	7	the	the	DT
cord-342936-43u7afl3	7	8	human	human	JJ
cord-342936-43u7afl3	7	9	host	host	NN
cord-342936-43u7afl3	7	10	,	,	,
cord-342936-43u7afl3	7	11	as	as	IN
cord-342936-43u7afl3	7	12	recently	recently	RB
cord-342936-43u7afl3	7	13	exemplified	exemplify	VBN
cord-342936-43u7afl3	7	14	by	by	IN
cord-342936-43u7afl3	7	15	influenza	influenza	NN
cord-342936-43u7afl3	7	16	viruses	virus	NNS
cord-342936-43u7afl3	7	17	and	and	CC
cord-342936-43u7afl3	7	18	the	the	DT
cord-342936-43u7afl3	7	19	severe	severe	JJ
cord-342936-43u7afl3	7	20	acute	acute	JJ
cord-342936-43u7afl3	7	21	respiratory	respiratory	JJ
cord-342936-43u7afl3	7	22	syndrome	syndrome	NN
cord-342936-43u7afl3	7	23	coronavirus	coronavirus	NN
cord-342936-43u7afl3	7	24	,	,	,
cord-342936-43u7afl3	7	25	is	be	VBZ
cord-342936-43u7afl3	7	26	also	also	RB
cord-342936-43u7afl3	7	27	a	a	DT
cord-342936-43u7afl3	7	28	continuous	continuous	JJ
cord-342936-43u7afl3	7	29	threat	threat	NN
cord-342936-43u7afl3	7	30	.	.	.
cord-342936-43u7afl3	8	1	There	there	EX
cord-342936-43u7afl3	8	2	is	be	VBZ
cord-342936-43u7afl3	8	3	a	a	DT
cord-342936-43u7afl3	8	4	high	high	JJ
cord-342936-43u7afl3	8	5	demand	demand	NN
cord-342936-43u7afl3	8	6	,	,	,
cord-342936-43u7afl3	8	7	therefore	therefore	RB
cord-342936-43u7afl3	8	8	,	,	,
cord-342936-43u7afl3	8	9	for	for	IN
cord-342936-43u7afl3	8	10	new	new	JJ
cord-342936-43u7afl3	8	11	antiviral	antiviral	JJ
cord-342936-43u7afl3	8	12	lead	lead	NN
cord-342936-43u7afl3	8	13	compounds	compound	NNS
cord-342936-43u7afl3	8	14	and	and	CC
cord-342936-43u7afl3	8	15	novel	novel	JJ
cord-342936-43u7afl3	8	16	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	8	17	concepts	concept	NNS
cord-342936-43u7afl3	8	18	.	.	.
cord-342936-43u7afl3	9	1	In	in	IN
cord-342936-43u7afl3	9	2	this	this	DT
cord-342936-43u7afl3	9	3	Review	Review	NNP
cord-342936-43u7afl3	9	4	,	,	,
cord-342936-43u7afl3	9	5	an	an	DT
cord-342936-43u7afl3	9	6	original	original	JJ
cord-342936-43u7afl3	9	7	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	9	8	concept	concept	NN
cord-342936-43u7afl3	9	9	for	for	IN
cord-342936-43u7afl3	9	10	suppressing	suppress	VBG
cord-342936-43u7afl3	9	11	enveloped	envelop	VBN
cord-342936-43u7afl3	9	12	viruses	virus	NNS
cord-342936-43u7afl3	9	13	is	be	VBZ
cord-342936-43u7afl3	9	14	presented	present	VBN
cord-342936-43u7afl3	9	15	that	that	WDT
cord-342936-43u7afl3	9	16	is	be	VBZ
cord-342936-43u7afl3	9	17	based	base	VBN
cord-342936-43u7afl3	9	18	on	on	IN
cord-342936-43u7afl3	9	19	a	a	DT
cord-342936-43u7afl3	9	20	specific	specific	JJ
cord-342936-43u7afl3	9	21	interaction	interaction	NN
cord-342936-43u7afl3	9	22	of	of	IN
cord-342936-43u7afl3	9	23	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	9	24	-	-	HYPH
cord-342936-43u7afl3	9	25	binding	bind	VBG
cord-342936-43u7afl3	9	26	agents	agent	NNS
cord-342936-43u7afl3	9	27	(	(	-LRB-
cord-342936-43u7afl3	9	28	CBAs	CBAs	NNP
cord-342936-43u7afl3	9	29	)	)	-RRB-
cord-342936-43u7afl3	9	30	with	with	IN
cord-342936-43u7afl3	9	31	the	the	DT
cord-342936-43u7afl3	9	32	glycans	glycan	NNS
cord-342936-43u7afl3	9	33	present	present	JJ
cord-342936-43u7afl3	9	34	on	on	IN
cord-342936-43u7afl3	9	35	viral	viral	JJ
cord-342936-43u7afl3	9	36	-	-	HYPH
cord-342936-43u7afl3	9	37	envelope	envelope	NN
cord-342936-43u7afl3	9	38	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	9	39	.	.	.
cord-342936-43u7afl3	10	1	This	this	DT
cord-342936-43u7afl3	10	2	approach	approach	NN
cord-342936-43u7afl3	10	3	may	may	MD
cord-342936-43u7afl3	10	4	also	also	RB
cord-342936-43u7afl3	10	5	be	be	VB
cord-342936-43u7afl3	10	6	extended	extend	VBN
cord-342936-43u7afl3	10	7	to	to	IN
cord-342936-43u7afl3	10	8	other	other	JJ
cord-342936-43u7afl3	10	9	pathogens	pathogen	NNS
cord-342936-43u7afl3	10	10	,	,	,
cord-342936-43u7afl3	10	11	including	include	VBG
cord-342936-43u7afl3	10	12	parasites	parasite	NNS
cord-342936-43u7afl3	10	13	,	,	,
cord-342936-43u7afl3	10	14	bacteria	bacteria	NNS
cord-342936-43u7afl3	10	15	and	and	CC
cord-342936-43u7afl3	10	16	fungi	fungus	NNS
cord-342936-43u7afl3	10	17	.	.	.
cord-342936-43u7afl3	11	1	Any	any	DT
cord-342936-43u7afl3	11	2	attempts	attempt	NNS
cord-342936-43u7afl3	11	3	to	to	TO
cord-342936-43u7afl3	11	4	develop	develop	VB
cord-342936-43u7afl3	11	5	an	an	DT
cord-342936-43u7afl3	11	6	efficient	efficient	JJ
cord-342936-43u7afl3	11	7	vaccine	vaccine	NN
cord-342936-43u7afl3	11	8	against	against	IN
cord-342936-43u7afl3	11	9	chronic	chronic	JJ
cord-342936-43u7afl3	11	10	viruses	virus	NNS
cord-342936-43u7afl3	11	11	,	,	,
cord-342936-43u7afl3	11	12	such	such	JJ
cord-342936-43u7afl3	11	13	as	as	IN
cord-342936-43u7afl3	11	14	HIV	HIV	NNP
cord-342936-43u7afl3	11	15	and	and	CC
cord-342936-43u7afl3	11	16	human	human	JJ
cord-342936-43u7afl3	11	17	hepatitis	hepatitis	NN
cord-342936-43u7afl3	11	18	C	C	NNP
cord-342936-43u7afl3	11	19	virus	virus	NN
cord-342936-43u7afl3	11	20	(	(	-LRB-
cord-342936-43u7afl3	11	21	HCV	HCV	NNP
cord-342936-43u7afl3	11	22	)	)	-RRB-
cord-342936-43u7afl3	11	23	,	,	,
cord-342936-43u7afl3	11	24	have	have	VBP
cord-342936-43u7afl3	11	25	so	so	RB
cord-342936-43u7afl3	11	26	far	far	RB
cord-342936-43u7afl3	11	27	failed	fail	VBN
cord-342936-43u7afl3	11	28	.	.	.
cord-342936-43u7afl3	12	1	This	this	DT
cord-342936-43u7afl3	12	2	is	be	VBZ
cord-342936-43u7afl3	12	3	mainly	mainly	RB
cord-342936-43u7afl3	12	4	due	due	JJ
cord-342936-43u7afl3	12	5	to	to	IN
cord-342936-43u7afl3	12	6	the	the	DT
cord-342936-43u7afl3	12	7	inventive	inventive	JJ
cord-342936-43u7afl3	12	8	immunological	immunological	JJ
cord-342936-43u7afl3	12	9	escape	escape	NN
cord-342936-43u7afl3	12	10	mechanisms	mechanism	NNS
cord-342936-43u7afl3	12	11	of	of	IN
cord-342936-43u7afl3	12	12	these	these	DT
cord-342936-43u7afl3	12	13	viruses	virus	NNS
cord-342936-43u7afl3	12	14	1,2	1,2	CD
cord-342936-43u7afl3	12	15	,	,	,
cord-342936-43u7afl3	12	16	as	as	RB
cord-342936-43u7afl3	12	17	well	well	RB
cord-342936-43u7afl3	12	18	as	as	IN
cord-342936-43u7afl3	12	19	a	a	DT
cord-342936-43u7afl3	12	20	lack	lack	NN
cord-342936-43u7afl3	12	21	of	of	IN
cord-342936-43u7afl3	12	22	efficient	efficient	JJ
cord-342936-43u7afl3	12	23	long	long	JJ
cord-342936-43u7afl3	12	24	-	-	HYPH
cord-342936-43u7afl3	12	25	term	term	NN
cord-342936-43u7afl3	12	26	protective	protective	JJ
cord-342936-43u7afl3	12	27	vaccines	vaccine	NNS
cord-342936-43u7afl3	12	28	that	that	WDT
cord-342936-43u7afl3	12	29	can	can	MD
cord-342936-43u7afl3	12	30	be	be	VB
cord-342936-43u7afl3	12	31	directed	direct	VBN
cord-342936-43u7afl3	12	32	against	against	IN
cord-342936-43u7afl3	12	33	conserved	conserved	JJ
cord-342936-43u7afl3	12	34	epitopes	epitope	NNS
cord-342936-43u7afl3	12	35	of	of	IN
cord-342936-43u7afl3	12	36	viruses	virus	NNS
cord-342936-43u7afl3	12	37	that	that	WDT
cord-342936-43u7afl3	12	38	are	be	VBP
cord-342936-43u7afl3	12	39	involved	involve	VBN
cord-342936-43u7afl3	12	40	in	in	IN
cord-342936-43u7afl3	12	41	acute	acute	JJ
cord-342936-43u7afl3	12	42	infections	infection	NNS
cord-342936-43u7afl3	12	43	(	(	-LRB-
cord-342936-43u7afl3	12	44	such	such	JJ
cord-342936-43u7afl3	12	45	as	as	IN
cord-342936-43u7afl3	12	46	the	the	DT
cord-342936-43u7afl3	12	47	influenza	influenza	NN
cord-342936-43u7afl3	12	48	virus	virus	NN
cord-342936-43u7afl3	12	49	)	)	-RRB-
cord-342936-43u7afl3	12	50	3	3	CD
cord-342936-43u7afl3	12	51	.	.	.
cord-342936-43u7afl3	13	1	Instead	instead	RB
cord-342936-43u7afl3	13	2	,	,	,
cord-342936-43u7afl3	13	3	a	a	DT
cord-342936-43u7afl3	13	4	broad	broad	JJ
cord-342936-43u7afl3	13	5	range	range	NN
cord-342936-43u7afl3	13	6	of	of	IN
cord-342936-43u7afl3	13	7	chemotherapeutic	chemotherapeutic	JJ
cord-342936-43u7afl3	13	8	agents	agent	NNS
cord-342936-43u7afl3	13	9	is	be	VBZ
cord-342936-43u7afl3	13	10	available	available	JJ
cord-342936-43u7afl3	13	11	for	for	IN
cord-342936-43u7afl3	13	12	the	the	DT
cord-342936-43u7afl3	13	13	treatment	treatment	NN
cord-342936-43u7afl3	13	14	of	of	IN
cord-342936-43u7afl3	13	15	various	various	JJ
cord-342936-43u7afl3	13	16	viral	viral	JJ
cord-342936-43u7afl3	13	17	infections	infection	NNS
cord-342936-43u7afl3	13	18	,	,	,
cord-342936-43u7afl3	13	19	in	in	IN
cord-342936-43u7afl3	13	20	particular	particular	JJ
cord-342936-43u7afl3	13	21	for	for	IN
cord-342936-43u7afl3	13	22	HIV	HIV	NNP
cord-342936-43u7afl3	13	23	4	4	CD
cord-342936-43u7afl3	13	24	.	.	.
cord-342936-43u7afl3	14	1	However	however	RB
cord-342936-43u7afl3	14	2	,	,	,
cord-342936-43u7afl3	14	3	the	the	DT
cord-342936-43u7afl3	14	4	appearance	appearance	NN
cord-342936-43u7afl3	14	5	of	of	IN
cord-342936-43u7afl3	14	6	long	long	JJ
cord-342936-43u7afl3	14	7	-	-	HYPH
cord-342936-43u7afl3	14	8	term	term	NN
cord-342936-43u7afl3	14	9	side	side	NN
cord-342936-43u7afl3	14	10	effects	effect	NNS
cord-342936-43u7afl3	14	11	and	and	CC
cord-342936-43u7afl3	14	12	,	,	,
cord-342936-43u7afl3	14	13	in	in	IN
cord-342936-43u7afl3	14	14	particular	particular	JJ
cord-342936-43u7afl3	14	15	,	,	,
cord-342936-43u7afl3	14	16	the	the	DT
cord-342936-43u7afl3	14	17	eventual	eventual	JJ
cord-342936-43u7afl3	14	18	emergence	emergence	NN
cord-342936-43u7afl3	14	19	of	of	IN
cord-342936-43u7afl3	14	20	viral	viral	JJ
cord-342936-43u7afl3	14	21	resistance	resistance	NN
cord-342936-43u7afl3	14	22	under	under	IN
cord-342936-43u7afl3	14	23	drug	drug	NN
cord-342936-43u7afl3	14	24	pressure	pressure	NN
cord-342936-43u7afl3	14	25	,	,	,
cord-342936-43u7afl3	14	26	often	often	RB
cord-342936-43u7afl3	14	27	weakens	weaken	VBZ
cord-342936-43u7afl3	14	28	the	the	DT
cord-342936-43u7afl3	14	29	therapy	therapy	NN
cord-342936-43u7afl3	14	30	and	and	CC
cord-342936-43u7afl3	14	31	makes	make	VBZ
cord-342936-43u7afl3	14	32	the	the	DT
cord-342936-43u7afl3	14	33	drugs	drug	NNS
cord-342936-43u7afl3	14	34	useless	useless	JJ
cord-342936-43u7afl3	14	35	and	and	CC
cord-342936-43u7afl3	14	36	even	even	RB
cord-342936-43u7afl3	14	37	harmful	harmful	JJ
cord-342936-43u7afl3	14	38	in	in	IN
cord-342936-43u7afl3	14	39	the	the	DT
cord-342936-43u7afl3	14	40	long	long	JJ
cord-342936-43u7afl3	14	41	run	run	NN
cord-342936-43u7afl3	14	42	.	.	.
cord-342936-43u7afl3	15	1	The	the	DT
cord-342936-43u7afl3	15	2	targets	target	NNS
cord-342936-43u7afl3	15	3	of	of	IN
cord-342936-43u7afl3	15	4	the	the	DT
cord-342936-43u7afl3	15	5	currently	currently	RB
cord-342936-43u7afl3	15	6	available	available	JJ
cord-342936-43u7afl3	15	7	antiviral	antiviral	JJ
cord-342936-43u7afl3	15	8	agents	agent	NNS
cord-342936-43u7afl3	15	9	are	be	VBP
cord-342936-43u7afl3	15	10	essential	essential	JJ
cord-342936-43u7afl3	15	11	virus	virus	NN
cord-342936-43u7afl3	15	12	-	-	HYPH
cord-342936-43u7afl3	15	13	encoded	encode	VBN
cord-342936-43u7afl3	15	14	enzymes	enzyme	NNS
cord-342936-43u7afl3	15	15	,	,	,
cord-342936-43u7afl3	15	16	virus	virus	NN
cord-342936-43u7afl3	15	17	-	-	HYPH
cord-342936-43u7afl3	15	18	specific	specific	JJ
cord-342936-43u7afl3	15	19	structural	structural	JJ
cord-342936-43u7afl3	15	20	proteins	protein	NNS
cord-342936-43u7afl3	15	21	or	or	CC
cord-342936-43u7afl3	15	22	cellular	cellular	JJ
cord-342936-43u7afl3	15	23	proteins	protein	NNS
cord-342936-43u7afl3	15	24	(	(	-LRB-
cord-342936-43u7afl3	15	25	that	that	RB
cord-342936-43u7afl3	15	26	is	is	RB
cord-342936-43u7afl3	15	27	,	,	,
cord-342936-43u7afl3	15	28	viral	viral	JJ
cord-342936-43u7afl3	15	29	receptors	receptor	NNS
cord-342936-43u7afl3	15	30	)	)	-RRB-
cord-342936-43u7afl3	15	31	4	4	CD
cord-342936-43u7afl3	15	32	,	,	,
cord-342936-43u7afl3	15	33	but	but	CC
cord-342936-43u7afl3	15	34	the	the	DT
cord-342936-43u7afl3	15	35	sometimes	sometimes	RB
cord-342936-43u7afl3	15	36	-	-	HYPH
cord-342936-43u7afl3	15	37	abundant	abundant	JJ
cord-342936-43u7afl3	15	38	presence	presence	NN
cord-342936-43u7afl3	15	39	of	of	IN
cord-342936-43u7afl3	15	40	glycans	glycan	NNS
cord-342936-43u7afl3	15	41	on	on	IN
cord-342936-43u7afl3	15	42	viral	viral	JJ
cord-342936-43u7afl3	15	43	-	-	HYPH
cord-342936-43u7afl3	15	44	envelope	envelope	NN
cord-342936-43u7afl3	15	45	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	15	46	has	have	VBZ
cord-342936-43u7afl3	15	47	never	never	RB
cord-342936-43u7afl3	15	48	been	be	VBN
cord-342936-43u7afl3	15	49	seriously	seriously	RB
cord-342936-43u7afl3	15	50	envisaged	envisage	VBN
cord-342936-43u7afl3	15	51	as	as	IN
cord-342936-43u7afl3	15	52	a	a	DT
cord-342936-43u7afl3	15	53	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	15	54	target	target	NN
cord-342936-43u7afl3	15	55	.	.	.
cord-342936-43u7afl3	16	1	Glycans	glycan	NNS
cord-342936-43u7afl3	16	2	on	on	IN
cord-342936-43u7afl3	16	3	the	the	DT
cord-342936-43u7afl3	16	4	viral	viral	JJ
cord-342936-43u7afl3	16	5	envelope	envelope	NN
cord-342936-43u7afl3	16	6	often	often	RB
cord-342936-43u7afl3	16	7	have	have	VBP
cord-342936-43u7afl3	16	8	a	a	DT
cord-342936-43u7afl3	16	9	crucial	crucial	JJ
cord-342936-43u7afl3	16	10	role	role	NN
cord-342936-43u7afl3	16	11	in	in	IN
cord-342936-43u7afl3	16	12	enabling	enable	VBG
cord-342936-43u7afl3	16	13	an	an	DT
cord-342936-43u7afl3	16	14	efficient	efficient	JJ
cord-342936-43u7afl3	16	15	transmission	transmission	NN
cord-342936-43u7afl3	16	16	of	of	IN
cord-342936-43u7afl3	16	17	the	the	DT
cord-342936-43u7afl3	16	18	pathogen	pathogen	NN
cord-342936-43u7afl3	16	19	and/or	and/or	CC
cord-342936-43u7afl3	16	20	entry	entry	NN
cord-342936-43u7afl3	16	21	into	into	IN
cord-342936-43u7afl3	16	22	its	-PRON-	PRP$
cord-342936-43u7afl3	16	23	susceptible	susceptible	JJ
cord-342936-43u7afl3	16	24	target	target	NN
cord-342936-43u7afl3	16	25	cells	cell	NNS
cord-342936-43u7afl3	16	26	.	.	.
cord-342936-43u7afl3	17	1	Moreover	moreover	RB
cord-342936-43u7afl3	17	2	,	,	,
cord-342936-43u7afl3	17	3	it	-PRON-	PRP
cord-342936-43u7afl3	17	4	has	have	VBZ
cord-342936-43u7afl3	17	5	been	be	VBN
cord-342936-43u7afl3	17	6	shown	show	VBN
cord-342936-43u7afl3	17	7	that	that	IN
cord-342936-43u7afl3	17	8	the	the	DT
cord-342936-43u7afl3	17	9	presence	presence	NN
cord-342936-43u7afl3	17	10	of	of	IN
cord-342936-43u7afl3	17	11	glycans	glycan	NNS
cord-342936-43u7afl3	17	12	on	on	IN
cord-342936-43u7afl3	17	13	the	the	DT
cord-342936-43u7afl3	17	14	envelope	envelope	NN
cord-342936-43u7afl3	17	15	of	of	IN
cord-342936-43u7afl3	17	16	viruses	virus	NNS
cord-342936-43u7afl3	17	17	,	,	,
cord-342936-43u7afl3	17	18	such	such	JJ
cord-342936-43u7afl3	17	19	as	as	IN
cord-342936-43u7afl3	17	20	HIV	HIV	NNP
cord-342936-43u7afl3	17	21	and	and	CC
cord-342936-43u7afl3	17	22	HCV	HCV	NNP
cord-342936-43u7afl3	17	23	,	,	,
cord-342936-43u7afl3	17	24	is	be	VBZ
cord-342936-43u7afl3	17	25	also	also	RB
cord-342936-43u7afl3	17	26	of	of	IN
cord-342936-43u7afl3	17	27	crucial	crucial	JJ
cord-342936-43u7afl3	17	28	importance	importance	NN
cord-342936-43u7afl3	17	29	for	for	IN
cord-342936-43u7afl3	17	30	the	the	DT
cord-342936-43u7afl3	17	31	evasion	evasion	NN
cord-342936-43u7afl3	17	32	of	of	IN
cord-342936-43u7afl3	17	33	the	the	DT
cord-342936-43u7afl3	17	34	immunological	immunological	JJ
cord-342936-43u7afl3	17	35	surveillance	surveillance	NN
cord-342936-43u7afl3	17	36	of	of	IN
cord-342936-43u7afl3	17	37	the	the	DT
cord-342936-43u7afl3	17	38	host	host	NN
cord-342936-43u7afl3	17	39	.	.	.
cord-342936-43u7afl3	18	1	Agents	agent	NNS
cord-342936-43u7afl3	18	2	that	that	WDT
cord-342936-43u7afl3	18	3	interact	interact	VBP
cord-342936-43u7afl3	18	4	with	with	IN
cord-342936-43u7afl3	18	5	the	the	DT
cord-342936-43u7afl3	18	6	viral	viral	JJ
cord-342936-43u7afl3	18	7	-	-	HYPH
cord-342936-43u7afl3	18	8	envelope	envelope	NN
cord-342936-43u7afl3	18	9	glycans	glycan	NNS
cord-342936-43u7afl3	18	10	may	may	MD
cord-342936-43u7afl3	18	11	,	,	,
cord-342936-43u7afl3	18	12	therefore	therefore	RB
cord-342936-43u7afl3	18	13	,	,	,
cord-342936-43u7afl3	18	14	compromise	compromise	VB
cord-342936-43u7afl3	18	15	the	the	DT
cord-342936-43u7afl3	18	16	efficient	efficient	JJ
cord-342936-43u7afl3	18	17	entry	entry	NN
cord-342936-43u7afl3	18	18	of	of	IN
cord-342936-43u7afl3	18	19	the	the	DT
cord-342936-43u7afl3	18	20	virus	virus	NN
cord-342936-43u7afl3	18	21	into	into	IN
cord-342936-43u7afl3	18	22	its	-PRON-	PRP$
cord-342936-43u7afl3	18	23	susceptible	susceptible	JJ
cord-342936-43u7afl3	18	24	target	target	NN
cord-342936-43u7afl3	18	25	cells	cell	NNS
cord-342936-43u7afl3	18	26	.	.	.
cord-342936-43u7afl3	19	1	Such	such	JJ
cord-342936-43u7afl3	19	2	agents	agent	NNS
cord-342936-43u7afl3	19	3	do	do	VBP
cord-342936-43u7afl3	19	4	not	not	RB
cord-342936-43u7afl3	19	5	interfere	interfere	VB
cord-342936-43u7afl3	19	6	with	with	IN
cord-342936-43u7afl3	19	7	the	the	DT
cord-342936-43u7afl3	19	8	glycosylation	glycosylation	NN
cord-342936-43u7afl3	19	9	enzymes	enzyme	NNS
cord-342936-43u7afl3	19	10	from	from	IN
cord-342936-43u7afl3	19	11	the	the	DT
cord-342936-43u7afl3	19	12	cell	cell	NN
cord-342936-43u7afl3	19	13	,	,	,
cord-342936-43u7afl3	19	14	but	but	CC
cord-342936-43u7afl3	19	15	rather	rather	RB
cord-342936-43u7afl3	19	16	act	act	VB
cord-342936-43u7afl3	19	17	by	by	IN
cord-342936-43u7afl3	19	18	directly	directly	RB
cord-342936-43u7afl3	19	19	binding	bind	VBG
cord-342936-43u7afl3	19	20	to	to	IN
cord-342936-43u7afl3	19	21	the	the	DT
cord-342936-43u7afl3	19	22	intact	intact	JJ
cord-342936-43u7afl3	19	23	glycans	glycan	NNS
cord-342936-43u7afl3	19	24	on	on	IN
cord-342936-43u7afl3	19	25	the	the	DT
cord-342936-43u7afl3	19	26	viral	viral	JJ
cord-342936-43u7afl3	19	27	envelope	envelope	NN
cord-342936-43u7afl3	19	28	.	.	.
cord-342936-43u7afl3	20	1	Perhaps	perhaps	RB
cord-342936-43u7afl3	20	2	more	more	RBR
cord-342936-43u7afl3	20	3	importantly	importantly	RB
cord-342936-43u7afl3	20	4	,	,	,
cord-342936-43u7afl3	20	5	such	such	JJ
cord-342936-43u7afl3	20	6	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	20	7	-	-	HYPH
cord-342936-43u7afl3	20	8	binding	bind	VBG
cord-342936-43u7afl3	20	9	agents	agent	NNS
cord-342936-43u7afl3	20	10	(	(	-LRB-
cord-342936-43u7afl3	20	11	CBAs	CBAs	NNP
cord-342936-43u7afl3	20	12	)	)	-RRB-
cord-342936-43u7afl3	20	13	may	may	MD
cord-342936-43u7afl3	20	14	force	force	VB
cord-342936-43u7afl3	20	15	the	the	DT
cord-342936-43u7afl3	20	16	virus	virus	NN
cord-342936-43u7afl3	20	17	to	to	TO
cord-342936-43u7afl3	20	18	delete	delete	VB
cord-342936-43u7afl3	20	19	at	at	IN
cord-342936-43u7afl3	20	20	least	least	JJS
cord-342936-43u7afl3	20	21	part	part	NN
cord-342936-43u7afl3	20	22	of	of	IN
cord-342936-43u7afl3	20	23	its	-PRON-	PRP$
cord-342936-43u7afl3	20	24	glycan	glycan	NN
cord-342936-43u7afl3	20	25	shield	shield	NN
cord-342936-43u7afl3	20	26	to	to	TO
cord-342936-43u7afl3	20	27	escape	escape	VB
cord-342936-43u7afl3	20	28	drug	drug	NN
cord-342936-43u7afl3	20	29	pressure	pressure	NN
cord-342936-43u7afl3	20	30	5	5	CD
cord-342936-43u7afl3	20	31	;	;	:
cord-342936-43u7afl3	20	32	this	this	DT
cord-342936-43u7afl3	20	33	might	may	MD
cord-342936-43u7afl3	20	34	result	result	VB
cord-342936-43u7afl3	20	35	in	in	IN
cord-342936-43u7afl3	20	36	the	the	DT
cord-342936-43u7afl3	20	37	initiation	initiation	NN
cord-342936-43u7afl3	20	38	of	of	IN
cord-342936-43u7afl3	20	39	an	an	DT
cord-342936-43u7afl3	20	40	immune	immune	JJ
cord-342936-43u7afl3	20	41	response	response	NN
cord-342936-43u7afl3	20	42	against	against	IN
cord-342936-43u7afl3	20	43	uncovered	uncover	VBN
cord-342936-43u7afl3	20	44	immunogenic	immunogenic	JJ
cord-342936-43u7afl3	20	45	envelope	envelope	NN
cord-342936-43u7afl3	20	46	epitopes	epitope	NNS
cord-342936-43u7afl3	20	47	.	.	.
cord-342936-43u7afl3	21	1	CBAs	cba	NNS
cord-342936-43u7afl3	21	2	may	may	MD
cord-342936-43u7afl3	21	3	become	become	VB
cord-342936-43u7afl3	21	4	the	the	DT
cord-342936-43u7afl3	21	5	first	first	JJ
cord-342936-43u7afl3	21	6	chemotherapeutics	chemotherapeutic	NNS
cord-342936-43u7afl3	21	7	with	with	IN
cord-342936-43u7afl3	21	8	a	a	DT
cord-342936-43u7afl3	21	9	dual	dual	JJ
cord-342936-43u7afl3	21	10	mechanism	mechanism	NN
cord-342936-43u7afl3	21	11	of	of	IN
cord-342936-43u7afl3	21	12	antiviral	antiviral	JJ
cord-342936-43u7afl3	21	13	action	action	NN
cord-342936-43u7afl3	21	14	:	:	:
cord-342936-43u7afl3	21	15	first	first	RB
cord-342936-43u7afl3	21	16	,	,	,
cord-342936-43u7afl3	21	17	through	through	IN
cord-342936-43u7afl3	21	18	direct	direct	JJ
cord-342936-43u7afl3	21	19	antiviral	antiviral	JJ
cord-342936-43u7afl3	21	20	activity	activity	NN
cord-342936-43u7afl3	21	21	,	,	,
cord-342936-43u7afl3	21	22	by	by	IN
cord-342936-43u7afl3	21	23	binding	bind	VBG
cord-342936-43u7afl3	21	24	to	to	IN
cord-342936-43u7afl3	21	25	the	the	DT
cord-342936-43u7afl3	21	26	glycans	glycan	NNS
cord-342936-43u7afl3	21	27	of	of	IN
cord-342936-43u7afl3	21	28	the	the	DT
cord-342936-43u7afl3	21	29	viral	viral	JJ
cord-342936-43u7afl3	21	30	envelope	envelope	NN
cord-342936-43u7afl3	21	31	and	and	CC
cord-342936-43u7afl3	21	32	subsequently	subsequently	RB
cord-342936-43u7afl3	21	33	blocking	block	VBG
cord-342936-43u7afl3	21	34	virus	virus	NN
cord-342936-43u7afl3	21	35	entry	entry	NN
cord-342936-43u7afl3	21	36	,	,	,
cord-342936-43u7afl3	21	37	and	and	CC
cord-342936-43u7afl3	21	38	second	second	RB
cord-342936-43u7afl3	21	39	,	,	,
cord-342936-43u7afl3	21	40	through	through	IN
cord-342936-43u7afl3	21	41	indirect	indirect	JJ
cord-342936-43u7afl3	21	42	(	(	-LRB-
cord-342936-43u7afl3	21	43	additional	additional	JJ
cord-342936-43u7afl3	21	44	)	)	-RRB-
cord-342936-43u7afl3	21	45	antiviral	antiviral	JJ
cord-342936-43u7afl3	21	46	action	action	NN
cord-342936-43u7afl3	21	47	resulting	result	VBG
cord-342936-43u7afl3	21	48	from	from	IN
cord-342936-43u7afl3	21	49	the	the	DT
cord-342936-43u7afl3	21	50	progressive	progressive	JJ
cord-342936-43u7afl3	21	51	creation	creation	NN
cord-342936-43u7afl3	21	52	of	of	IN
cord-342936-43u7afl3	21	53	deletions	deletion	NNS
cord-342936-43u7afl3	21	54	in	in	IN
cord-342936-43u7afl3	21	55	the	the	DT
cord-342936-43u7afl3	21	56	envelope	envelope	NN
cord-342936-43u7afl3	21	57	glycan	glycan	NN
cord-342936-43u7afl3	21	58	shield	shield	NN
cord-342936-43u7afl3	21	59	,	,	,
cord-342936-43u7afl3	21	60	thereby	thereby	RB
cord-342936-43u7afl3	21	61	triggering	trigger	VBG
cord-342936-43u7afl3	21	62	the	the	DT
cord-342936-43u7afl3	21	63	immune	immune	JJ
cord-342936-43u7afl3	21	64	system	system	NN
cord-342936-43u7afl3	21	65	to	to	TO
cord-342936-43u7afl3	21	66	act	act	VB
cord-342936-43u7afl3	21	67	against	against	IN
cord-342936-43u7afl3	21	68	previously	previously	RB
cord-342936-43u7afl3	21	69	hidden	hide	VBN
cord-342936-43u7afl3	21	70	immunogenic	immunogenic	JJ
cord-342936-43u7afl3	21	71	epitopes	epitope	NNS
cord-342936-43u7afl3	21	72	of	of	IN
cord-342936-43u7afl3	21	73	the	the	DT
cord-342936-43u7afl3	21	74	viral	viral	JJ
cord-342936-43u7afl3	21	75	envelope	envelope	NN
cord-342936-43u7afl3	21	76	(	(	-LRB-
cord-342936-43u7afl3	21	77	FIG	fig	NN
cord-342936-43u7afl3	21	78	.	.	.
cord-342936-43u7afl3	21	79	1	1	CD
cord-342936-43u7afl3	21	80	)	)	-RRB-
cord-342936-43u7afl3	21	81	.	.	.
cord-342936-43u7afl3	22	1	In	in	IN
cord-342936-43u7afl3	22	2	the	the	DT
cord-342936-43u7afl3	22	3	broader	broad	JJR
cord-342936-43u7afl3	22	4	perspective	perspective	NN
cord-342936-43u7afl3	22	5	,	,	,
cord-342936-43u7afl3	22	6	apart	apart	RB
cord-342936-43u7afl3	22	7	from	from	IN
cord-342936-43u7afl3	22	8	viruses	virus	NNS
cord-342936-43u7afl3	22	9	,	,	,
cord-342936-43u7afl3	22	10	other	other	JJ
cord-342936-43u7afl3	22	11	pathogens	pathogen	NNS
cord-342936-43u7afl3	22	12	such	such	JJ
cord-342936-43u7afl3	22	13	as	as	IN
cord-342936-43u7afl3	22	14	Mycobacterium	Mycobacterium	NNP
cord-342936-43u7afl3	22	15	tuberculosis	tuberculosis	NN
cord-342936-43u7afl3	22	16	,	,	,
cord-342936-43u7afl3	22	17	Helicobacter	helicobacter	NN
cord-342936-43u7afl3	22	18	pylori	pylori	NN
cord-342936-43u7afl3	22	19	and	and	CC
cord-342936-43u7afl3	22	20	some	some	DT
cord-342936-43u7afl3	22	21	parasites	parasite	NNS
cord-342936-43u7afl3	22	22	may	may	MD
cord-342936-43u7afl3	22	23	also	also	RB
cord-342936-43u7afl3	22	24	be	be	VB
cord-342936-43u7afl3	22	25	susceptible	susceptible	JJ
cord-342936-43u7afl3	22	26	to	to	IN
cord-342936-43u7afl3	22	27	this	this	DT
cord-342936-43u7afl3	22	28	novel	novel	JJ
cord-342936-43u7afl3	22	29	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	22	30	approach	approach	NN
cord-342936-43u7afl3	22	31	.	.	.
cord-342936-43u7afl3	23	1	This	this	DT
cord-342936-43u7afl3	23	2	Review	Review	NNP
cord-342936-43u7afl3	23	3	will	will	MD
cord-342936-43u7afl3	23	4	focus	focus	VB
cord-342936-43u7afl3	23	5	on	on	IN
cord-342936-43u7afl3	23	6	CBAs	cba	NNS
cord-342936-43u7afl3	23	7	and	and	CC
cord-342936-43u7afl3	23	8	the	the	DT
cord-342936-43u7afl3	23	9	molecular	molecular	JJ
cord-342936-43u7afl3	23	10	mechanism	mechanism	NN
cord-342936-43u7afl3	23	11	of	of	IN
cord-342936-43u7afl3	23	12	their	-PRON-	PRP$
cord-342936-43u7afl3	23	13	antiviral	antiviral	JJ
cord-342936-43u7afl3	23	14	activity	activity	NN
cord-342936-43u7afl3	23	15	(	(	-LRB-
cord-342936-43u7afl3	23	16	FIG	fig	NN
cord-342936-43u7afl3	23	17	.	.	.
cord-342936-43u7afl3	23	18	1	1	CD
cord-342936-43u7afl3	23	19	)	)	-RRB-
cord-342936-43u7afl3	23	20	.	.	.
cord-342936-43u7afl3	24	1	The	the	DT
cord-342936-43u7afl3	24	2	escape	escape	NN
cord-342936-43u7afl3	24	3	mechanisms	mechanism	NNS
cord-342936-43u7afl3	24	4	of	of	IN
cord-342936-43u7afl3	24	5	HIV	HIV	NNP
cord-342936-43u7afl3	24	6	in	in	IN
cord-342936-43u7afl3	24	7	response	response	NN
cord-342936-43u7afl3	24	8	to	to	IN
cord-342936-43u7afl3	24	9	CBA	CBA	NNP
cord-342936-43u7afl3	24	10	pressure	pressure	NN
cord-342936-43u7afl3	24	11	and	and	CC
cord-342936-43u7afl3	24	12	how	how	WRB
cord-342936-43u7afl3	24	13	these	these	DT
cord-342936-43u7afl3	24	14	escape	escape	NN
cord-342936-43u7afl3	24	15	mechanisms	mechanism	NNS
cord-342936-43u7afl3	24	16	might	may	MD
cord-342936-43u7afl3	24	17	involve	involve	VB
cord-342936-43u7afl3	24	18	the	the	DT
cord-342936-43u7afl3	24	19	immune	immune	JJ
cord-342936-43u7afl3	24	20	system	system	NN
cord-342936-43u7afl3	24	21	to	to	TO
cord-342936-43u7afl3	24	22	further	far	RBR
cord-342936-43u7afl3	24	23	combat	combat	VB
cord-342936-43u7afl3	24	24	the	the	DT
cord-342936-43u7afl3	24	25	viral	viral	JJ
cord-342936-43u7afl3	24	26	infection	infection	NN
cord-342936-43u7afl3	24	27	will	will	MD
cord-342936-43u7afl3	24	28	also	also	RB
cord-342936-43u7afl3	24	29	be	be	VB
cord-342936-43u7afl3	24	30	discussed	discuss	VBN
cord-342936-43u7afl3	24	31	.	.	.
cord-342936-43u7afl3	25	1	The	the	DT
cord-342936-43u7afl3	25	2	interference	interference	NN
cord-342936-43u7afl3	25	3	of	of	IN
cord-342936-43u7afl3	25	4	CBAs	cba	NNS
cord-342936-43u7afl3	25	5	with	with	IN
cord-342936-43u7afl3	25	6	the	the	DT
cord-342936-43u7afl3	25	7	dendritic	dendritic	JJ
cord-342936-43u7afl3	25	8	cell	cell	NN
cord-342936-43u7afl3	25	9	(	(	-LRB-
cord-342936-43u7afl3	25	10	DC)-specific	dc)-specific	CD
cord-342936-43u7afl3	25	11	intercellular	intercellular	JJ
cord-342936-43u7afl3	25	12	adhesion	adhesion	NN
cord-342936-43u7afl3	25	13	molecule	molecule	NN
cord-342936-43u7afl3	25	14	3	3	CD
cord-342936-43u7afl3	25	15	(	(	-LRB-
cord-342936-43u7afl3	25	16	ICAM-3)-grabbing	icam-3)-grabbe	VBG
cord-342936-43u7afl3	25	17	non	non	JJ
cord-342936-43u7afl3	25	18	-	-	JJ
cord-342936-43u7afl3	25	19	integrin	integrin	JJ
cord-342936-43u7afl3	25	20	(	(	-LRB-
cord-342936-43u7afl3	25	21	DC	DC	NNP
cord-342936-43u7afl3	25	22	-	-	HYPH
cord-342936-43u7afl3	25	23	SIGN)-directed	sign)-directe	VBN
cord-342936-43u7afl3	25	24	capture	capture	NN
cord-342936-43u7afl3	25	25	and	and	CC
cord-342936-43u7afl3	25	26	transmission	transmission	NN
cord-342936-43u7afl3	25	27	of	of	IN
cord-342936-43u7afl3	25	28	HIV	HIV	NNP
cord-342936-43u7afl3	25	29	and	and	CC
cord-342936-43u7afl3	25	30	other	other	JJ
cord-342936-43u7afl3	25	31	pathogens	pathogen	NNS
cord-342936-43u7afl3	25	32	will	will	MD
cord-342936-43u7afl3	25	33	also	also	RB
cord-342936-43u7afl3	25	34	be	be	VB
cord-342936-43u7afl3	25	35	highlighted	highlight	VBN
cord-342936-43u7afl3	25	36	,	,	,
cord-342936-43u7afl3	25	37	and	and	CC
cord-342936-43u7afl3	25	38	the	the	DT
cord-342936-43u7afl3	25	39	unique	unique	JJ
cord-342936-43u7afl3	25	40	features	feature	NNS
cord-342936-43u7afl3	25	41	of	of	IN
cord-342936-43u7afl3	25	42	the	the	DT
cord-342936-43u7afl3	25	43	CBA	CBA	NNP
cord-342936-43u7afl3	25	44	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	25	45	concept	concept	NN
cord-342936-43u7afl3	25	46	and	and	CC
cord-342936-43u7afl3	25	47	its	-PRON-	PRP$
cord-342936-43u7afl3	25	48	potential	potential	JJ
cord-342936-43u7afl3	25	49	pitfalls	pitfall	NNS
cord-342936-43u7afl3	25	50	will	will	MD
cord-342936-43u7afl3	25	51	be	be	VB
cord-342936-43u7afl3	25	52	discussed	discuss	VBN
cord-342936-43u7afl3	25	53	.	.	.
cord-342936-43u7afl3	26	1	Mannose	mannose	NN
cord-342936-43u7afl3	26	2	-	-	HYPH
cord-342936-43u7afl3	26	3	binding	bind	VBG
cord-342936-43u7afl3	26	4	lectins	lectin	NNS
cord-342936-43u7afl3	26	5	(	(	-LRB-
cord-342936-43u7afl3	26	6	MBLs	mbl	NNS
cord-342936-43u7afl3	26	7	)	)	-RRB-
cord-342936-43u7afl3	26	8	.	.	.
cord-342936-43u7afl3	27	1	A	a	DT
cord-342936-43u7afl3	27	2	superfamily	superfamily	NN
cord-342936-43u7afl3	27	3	of	of	IN
cord-342936-43u7afl3	27	4	strictly	strictly	RB
cord-342936-43u7afl3	27	5	mannose	mannose	NN
cord-342936-43u7afl3	27	6	-	-	HYPH
cord-342936-43u7afl3	27	7	specific	specific	JJ
cord-342936-43u7afl3	27	8	lectins	lectin	NNS
cord-342936-43u7afl3	27	9	,	,	,
cord-342936-43u7afl3	27	10	all	all	DT
cord-342936-43u7afl3	27	11	of	of	IN
cord-342936-43u7afl3	27	12	which	which	WDT
cord-342936-43u7afl3	27	13	consist	consist	VBP
cord-342936-43u7afl3	27	14	of	of	IN
cord-342936-43u7afl3	27	15	subunits	subunit	NNS
cord-342936-43u7afl3	27	16	with	with	IN
cord-342936-43u7afl3	27	17	a	a	DT
cord-342936-43u7afl3	27	18	similar	similar	JJ
cord-342936-43u7afl3	27	19	sequence	sequence	NN
cord-342936-43u7afl3	27	20	and	and	CC
cord-342936-43u7afl3	27	21	overall	overall	JJ
cord-342936-43u7afl3	27	22	threedimensional	threedimensional	JJ
cord-342936-43u7afl3	27	23	structure	structure	NN
cord-342936-43u7afl3	27	24	.	.	.
cord-342936-43u7afl3	28	1	Glycosylation	glycosylation	NN
cord-342936-43u7afl3	28	2	is	be	VBZ
cord-342936-43u7afl3	28	3	a	a	DT
cord-342936-43u7afl3	28	4	highly	highly	RB
cord-342936-43u7afl3	28	5	diverse	diverse	JJ
cord-342936-43u7afl3	28	6	co	co	NN
cord-342936-43u7afl3	28	7	-	-	JJ
cord-342936-43u7afl3	28	8	and	and	CC
cord-342936-43u7afl3	28	9	post	post	JJ
cord-342936-43u7afl3	28	10	-	-	JJ
cord-342936-43u7afl3	28	11	translational	translational	JJ
cord-342936-43u7afl3	28	12	protein	protein	NN
cord-342936-43u7afl3	28	13	-	-	HYPH
cord-342936-43u7afl3	28	14	modification	modification	NN
cord-342936-43u7afl3	28	15	reaction	reaction	NN
cord-342936-43u7afl3	28	16	that	that	WDT
cord-342936-43u7afl3	28	17	can	can	MD
cord-342936-43u7afl3	28	18	be	be	VB
cord-342936-43u7afl3	28	19	broadly	broadly	RB
cord-342936-43u7afl3	28	20	divided	divide	VBN
cord-342936-43u7afl3	28	21	into	into	IN
cord-342936-43u7afl3	28	22	two	two	CD
cord-342936-43u7afl3	28	23	categories	category	NNS
cord-342936-43u7afl3	28	24	;	;	:
cord-342936-43u7afl3	28	25	O	o	NN
cord-342936-43u7afl3	28	26	-	-	HYPH
cord-342936-43u7afl3	28	27	linked	link	VBN
cord-342936-43u7afl3	28	28	and	and	CC
cord-342936-43u7afl3	28	29	N	n	CD
cord-342936-43u7afl3	28	30	-	-	HYPH
cord-342936-43u7afl3	28	31	linked	link	VBN
cord-342936-43u7afl3	28	32	glycosylation	glycosylation	NN
cord-342936-43u7afl3	28	33	.	.	.
cord-342936-43u7afl3	29	1	In	in	IN
cord-342936-43u7afl3	29	2	O	o	NN
cord-342936-43u7afl3	29	3	-	-	HYPH
cord-342936-43u7afl3	29	4	linked	link	VBN
cord-342936-43u7afl3	29	5	glycosylation	glycosylation	NN
cord-342936-43u7afl3	29	6	,	,	,
cord-342936-43u7afl3	29	7	which	which	WDT
cord-342936-43u7afl3	29	8	probably	probably	RB
cord-342936-43u7afl3	29	9	occurs	occur	VBZ
cord-342936-43u7afl3	29	10	in	in	IN
cord-342936-43u7afl3	29	11	the	the	DT
cord-342936-43u7afl3	29	12	Golgi	Golgi	NNP
cord-342936-43u7afl3	29	13	apparatus	apparatus	NN
cord-342936-43u7afl3	29	14	,	,	,
cord-342936-43u7afl3	29	15	the	the	DT
cord-342936-43u7afl3	29	16	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	29	17	moiety	moiety	NN
cord-342936-43u7afl3	29	18	is	be	VBZ
cord-342936-43u7afl3	29	19	covalently	covalently	RB
cord-342936-43u7afl3	29	20	linked	link	VBN
cord-342936-43u7afl3	29	21	to	to	IN
cord-342936-43u7afl3	29	22	the	the	DT
cord-342936-43u7afl3	29	23	hydroxyl	hydroxyl	NN
cord-342936-43u7afl3	29	24	oxygen	oxygen	NN
cord-342936-43u7afl3	29	25	of	of	IN
cord-342936-43u7afl3	29	26	serine	serine	NN
cord-342936-43u7afl3	29	27	and	and	CC
cord-342936-43u7afl3	29	28	threonine	threonine	NN
cord-342936-43u7afl3	29	29	,	,	,
cord-342936-43u7afl3	29	30	but	but	CC
cord-342936-43u7afl3	29	31	it	-PRON-	PRP
cord-342936-43u7afl3	29	32	can	can	MD
cord-342936-43u7afl3	29	33	also	also	RB
cord-342936-43u7afl3	29	34	be	be	VB
cord-342936-43u7afl3	29	35	bound	bind	VBN
cord-342936-43u7afl3	29	36	to	to	IN
cord-342936-43u7afl3	29	37	tyrosine	tyrosine	NN
cord-342936-43u7afl3	29	38	,	,	,
cord-342936-43u7afl3	29	39	or	or	CC
cord-342936-43u7afl3	29	40	to	to	IN
cord-342936-43u7afl3	29	41	5-hydroxylysine	5-hydroxylysine	CD
cord-342936-43u7afl3	29	42	and	and	CC
cord-342936-43u7afl3	29	43	4-hydroxyproline	4-hydroxyproline	CD
cord-342936-43u7afl3	29	44	6	6	CD
cord-342936-43u7afl3	29	45	.	.	.
cord-342936-43u7afl3	30	1	O	o	NN
cord-342936-43u7afl3	30	2	-	-	HYPH
cord-342936-43u7afl3	30	3	glycosylation	glycosylation	NN
cord-342936-43u7afl3	30	4	has	have	VBZ
cord-342936-43u7afl3	30	5	various	various	JJ
cord-342936-43u7afl3	30	6	functions	function	NNS
cord-342936-43u7afl3	30	7	,	,	,
cord-342936-43u7afl3	30	8	such	such	JJ
cord-342936-43u7afl3	30	9	as	as	IN
cord-342936-43u7afl3	30	10	providing	provide	VBG
cord-342936-43u7afl3	30	11	ligands	ligand	NNS
cord-342936-43u7afl3	30	12	for	for	IN
cord-342936-43u7afl3	30	13	selectins	selectin	NNS
cord-342936-43u7afl3	30	14	,	,	,
cord-342936-43u7afl3	30	15	resistance	resistance	NN
cord-342936-43u7afl3	30	16	to	to	IN
cord-342936-43u7afl3	30	17	proteolysis	proteolysis	NN
cord-342936-43u7afl3	30	18	of	of	IN
cord-342936-43u7afl3	30	19	stem	stem	NN
cord-342936-43u7afl3	30	20	regions	region	NNS
cord-342936-43u7afl3	30	21	of	of	IN
cord-342936-43u7afl3	30	22	membrane	membrane	NN
cord-342936-43u7afl3	30	23	proteins	protein	NNS
cord-342936-43u7afl3	30	24	and	and	CC
cord-342936-43u7afl3	30	25	creating	create	VBG
cord-342936-43u7afl3	30	26	specific	specific	JJ
cord-342936-43u7afl3	30	27	recognition	recognition	NN
cord-342936-43u7afl3	30	28	phenomena	phenomena	VBN
cord-342936-43u7afl3	30	29	6	6	CD
cord-342936-43u7afl3	30	30	.	.	.
cord-342936-43u7afl3	31	1	It	-PRON-	PRP
cord-342936-43u7afl3	31	2	can	can	MD
cord-342936-43u7afl3	31	3	also	also	RB
cord-342936-43u7afl3	31	4	help	help	VB
cord-342936-43u7afl3	31	5	to	to	TO
cord-342936-43u7afl3	31	6	mask	mask	VB
cord-342936-43u7afl3	31	7	immunogenic	immunogenic	JJ
cord-342936-43u7afl3	31	8	epitopes	epitope	NNS
cord-342936-43u7afl3	31	9	on	on	IN
cord-342936-43u7afl3	31	10	the	the	DT
cord-342936-43u7afl3	31	11	protein	protein	NN
cord-342936-43u7afl3	31	12	.	.	.
cord-342936-43u7afl3	32	1	O	o	UH
cord-342936-43u7afl3	32	2	-	-	HYPH
cord-342936-43u7afl3	32	3	linked	link	VBN
cord-342936-43u7afl3	32	4	glycosylation	glycosylation	NN
cord-342936-43u7afl3	32	5	usually	usually	RB
cord-342936-43u7afl3	32	6	has	have	VBZ
cord-342936-43u7afl3	32	7	N	n	CD
cord-342936-43u7afl3	32	8	-	-	HYPH
cord-342936-43u7afl3	32	9	acetylgalactosamine	acetylgalactosamine	JJ
cord-342936-43u7afl3	32	10	(	(	-LRB-
cord-342936-43u7afl3	32	11	GalNAc	GalNAc	NNP
cord-342936-43u7afl3	32	12	)	)	-RRB-
cord-342936-43u7afl3	32	13	as	as	IN
cord-342936-43u7afl3	32	14	the	the	DT
cord-342936-43u7afl3	32	15	binding	bind	VBG
cord-342936-43u7afl3	32	16	sugar	sugar	NN
cord-342936-43u7afl3	32	17	but	but	CC
cord-342936-43u7afl3	32	18	can	can	MD
cord-342936-43u7afl3	32	19	also	also	RB
cord-342936-43u7afl3	32	20	involve	involve	VB
cord-342936-43u7afl3	32	21	other	other	JJ
cord-342936-43u7afl3	32	22	sugars	sugar	NNS
cord-342936-43u7afl3	32	23	,	,	,
cord-342936-43u7afl3	32	24	such	such	JJ
cord-342936-43u7afl3	32	25	as	as	IN
cord-342936-43u7afl3	32	26	fucose	fucose	JJ
cord-342936-43u7afl3	32	27	,	,	,
cord-342936-43u7afl3	32	28	glucose	glucose	NN
cord-342936-43u7afl3	32	29	and	and	CC
cord-342936-43u7afl3	32	30	N	N	NNP
cord-342936-43u7afl3	32	31	-	-	HYPH
cord-342936-43u7afl3	32	32	acetylglucosamine	acetylglucosamine	NNP
cord-342936-43u7afl3	32	33	(	(	-LRB-
cord-342936-43u7afl3	32	34	GlcNAc	GlcNAc	NNP
cord-342936-43u7afl3	32	35	)	)	-RRB-
cord-342936-43u7afl3	32	36	.	.	.
cord-342936-43u7afl3	33	1	Galactose	galactose	NN
cord-342936-43u7afl3	33	2	and/or	and/or	CC
cord-342936-43u7afl3	33	3	sialic	sialic	NN
cord-342936-43u7afl3	33	4	acid	acid	NN
cord-342936-43u7afl3	33	5	are	be	VBP
cord-342936-43u7afl3	33	6	also	also	RB
cord-342936-43u7afl3	33	7	often	often	RB
cord-342936-43u7afl3	33	8	found	find	VBN
cord-342936-43u7afl3	33	9	in	in	IN
cord-342936-43u7afl3	33	10	O	o	NN
cord-342936-43u7afl3	33	11	-	-	HYPH
cord-342936-43u7afl3	33	12	glycans	glycan	NNS
cord-342936-43u7afl3	33	13	.	.	.
cord-342936-43u7afl3	34	1	The	the	DT
cord-342936-43u7afl3	34	2	covalently	covalently	RB
cord-342936-43u7afl3	34	3	N	n	NN
cord-342936-43u7afl3	34	4	-	-	HYPH
cord-342936-43u7afl3	34	5	linked	link	VBN
cord-342936-43u7afl3	34	6	glycans	glycan	NNS
cord-342936-43u7afl3	34	7	(	(	-LRB-
cord-342936-43u7afl3	34	8	FIG	fig	NN
cord-342936-43u7afl3	34	9	.	.	.
cord-342936-43u7afl3	34	10	2	2	LS
cord-342936-43u7afl3	34	11	)	)	-RRB-
cord-342936-43u7afl3	34	12	are	be	VBP
cord-342936-43u7afl3	34	13	added	add	VBN
cord-342936-43u7afl3	34	14	co	co	NN
cord-342936-43u7afl3	34	15	-	-	NN
cord-342936-43u7afl3	34	16	translationally	translationally	RB
cord-342936-43u7afl3	34	17	to	to	IN
cord-342936-43u7afl3	34	18	native	native	JJ
cord-342936-43u7afl3	34	19	polypeptides	polypeptide	NNS
cord-342936-43u7afl3	34	20	in	in	IN
cord-342936-43u7afl3	34	21	the	the	DT
cord-342936-43u7afl3	34	22	endoplasmic	endoplasmic	NN
cord-342936-43u7afl3	34	23	reticulum	reticulum	NN
cord-342936-43u7afl3	34	24	(	(	-LRB-
cord-342936-43u7afl3	34	25	ER	ER	NNP
cord-342936-43u7afl3	34	26	)	)	-RRB-
cord-342936-43u7afl3	34	27	as	as	IN
cord-342936-43u7afl3	34	28	blocks	block	NNS
cord-342936-43u7afl3	34	29	of	of	IN
cord-342936-43u7afl3	34	30	fourteen	fourteen	CD
cord-342936-43u7afl3	34	31	sugars	sugar	NNS
cord-342936-43u7afl3	35	1	(	(	-LRB-
cord-342936-43u7afl3	35	2	Glc	Glc	NNP
cord-342936-43u7afl3	35	3	3	3	CD
cord-342936-43u7afl3	35	4	Man	Man	NNP
cord-342936-43u7afl3	35	5	9	9	CD
cord-342936-43u7afl3	35	6	GlcNAc	glcnac	NN
cord-342936-43u7afl3	35	7	2	2	CD
cord-342936-43u7afl3	35	8	)	)	-RRB-
cord-342936-43u7afl3	35	9	.	.	.
cord-342936-43u7afl3	36	1	These	these	DT
cord-342936-43u7afl3	36	2	glycans	glycan	NNS
cord-342936-43u7afl3	36	3	are	be	VBP
cord-342936-43u7afl3	36	4	then	then	RB
cord-342936-43u7afl3	36	5	subject	subject	JJ
cord-342936-43u7afl3	36	6	to	to	IN
cord-342936-43u7afl3	36	7	extensive	extensive	JJ
cord-342936-43u7afl3	36	8	modification	modification	NN
cord-342936-43u7afl3	36	9	during	during	IN
cord-342936-43u7afl3	36	10	their	-PRON-	PRP$
cord-342936-43u7afl3	36	11	transport	transport	NN
cord-342936-43u7afl3	36	12	through	through	IN
cord-342936-43u7afl3	36	13	the	the	DT
cord-342936-43u7afl3	36	14	ER	ER	NNP
cord-342936-43u7afl3	36	15	and	and	CC
cord-342936-43u7afl3	36	16	the	the	DT
cord-342936-43u7afl3	36	17	Golgi	Golgi	NNP
cord-342936-43u7afl3	36	18	complex	complex	NN
cord-342936-43u7afl3	36	19	before	before	IN
cord-342936-43u7afl3	36	20	reaching	reach	VBG
cord-342936-43u7afl3	36	21	their	-PRON-	PRP$
cord-342936-43u7afl3	36	22	final	final	JJ
cord-342936-43u7afl3	36	23	destinations	destination	NNS
cord-342936-43u7afl3	36	24	inside	inside	IN
cord-342936-43u7afl3	36	25	or	or	CC
cord-342936-43u7afl3	36	26	outside	outside	IN
cord-342936-43u7afl3	36	27	the	the	DT
cord-342936-43u7afl3	36	28	cell	cell	NN
cord-342936-43u7afl3	36	29	7	7	CD
cord-342936-43u7afl3	36	30	.	.	.
cord-342936-43u7afl3	37	1	In	in	IN
cord-342936-43u7afl3	37	2	the	the	DT
cord-342936-43u7afl3	37	3	ER	er	NN
cord-342936-43u7afl3	37	4	and	and	CC
cord-342936-43u7afl3	37	5	the	the	DT
cord-342936-43u7afl3	37	6	early	early	JJ
cord-342936-43u7afl3	37	7	secretory	secretory	JJ
cord-342936-43u7afl3	37	8	pathway	pathway	NN
cord-342936-43u7afl3	37	9	,	,	,
cord-342936-43u7afl3	37	10	the	the	DT
cord-342936-43u7afl3	37	11	oligosaccharide	oligosaccharide	NN
cord-342936-43u7afl3	37	12	repertoire	repertoire	NN
cord-342936-43u7afl3	37	13	is	be	VBZ
cord-342936-43u7afl3	37	14	still	still	RB
cord-342936-43u7afl3	37	15	small	small	JJ
cord-342936-43u7afl3	37	16	.	.	.
cord-342936-43u7afl3	38	1	In	in	IN
cord-342936-43u7afl3	38	2	the	the	DT
cord-342936-43u7afl3	38	3	Golgi	Golgi	NNP
cord-342936-43u7afl3	38	4	complex	complex	NN
cord-342936-43u7afl3	38	5	,	,	,
cord-342936-43u7afl3	38	6	however	however	RB
cord-342936-43u7afl3	38	7	,	,	,
cord-342936-43u7afl3	38	8	the	the	DT
cord-342936-43u7afl3	38	9	glycans	glycan	NNS
cord-342936-43u7afl3	38	10	acquire	acquire	VBP
cord-342936-43u7afl3	38	11	complex	complex	JJ
cord-342936-43u7afl3	38	12	and	and	CC
cord-342936-43u7afl3	38	13	highly	highly	RB
cord-342936-43u7afl3	38	14	diverse	diverse	JJ
cord-342936-43u7afl3	38	15	structures	structure	NNS
cord-342936-43u7afl3	38	16	by	by	IN
cord-342936-43u7afl3	38	17	terminal	terminal	JJ
cord-342936-43u7afl3	38	18	glycosylation	glycosylation	NN
cord-342936-43u7afl3	38	19	,	,	,
cord-342936-43u7afl3	38	20	which	which	WDT
cord-342936-43u7afl3	38	21	results	result	VBZ
cord-342936-43u7afl3	38	22	in	in	IN
cord-342936-43u7afl3	38	23	a	a	DT
cord-342936-43u7afl3	38	24	tremendous	tremendous	JJ
cord-342936-43u7afl3	38	25	heterogeneity	heterogeneity	NN
cord-342936-43u7afl3	38	26	.	.	.
cord-342936-43u7afl3	39	1	Such	such	JJ
cord-342936-43u7afl3	39	2	diversity	diversity	NN
cord-342936-43u7afl3	39	3	differs	differ	VBZ
cord-342936-43u7afl3	39	4	between	between	IN
cord-342936-43u7afl3	39	5	cell	cell	NN
cord-342936-43u7afl3	39	6	types	type	NNS
cord-342936-43u7afl3	39	7	,	,	,
cord-342936-43u7afl3	39	8	tissues	tissue	NNS
cord-342936-43u7afl3	39	9	and	and	CC
cord-342936-43u7afl3	39	10	species	specie	NNS
cord-342936-43u7afl3	39	11	,	,	,
cord-342936-43u7afl3	39	12	and	and	CC
cord-342936-43u7afl3	39	13	helps	help	VBZ
cord-342936-43u7afl3	39	14	to	to	TO
cord-342936-43u7afl3	39	15	further	further	RB
cord-342936-43u7afl3	39	16	increase	increase	VB
cord-342936-43u7afl3	39	17	microheterogeneity	microheterogeneity	NN
cord-342936-43u7afl3	39	18	in	in	IN
cord-342936-43u7afl3	39	19	the	the	DT
cord-342936-43u7afl3	39	20	presence	presence	NN
cord-342936-43u7afl3	39	21	of	of	IN
cord-342936-43u7afl3	39	22	an	an	DT
cord-342936-43u7afl3	39	23	identical	identical	JJ
cord-342936-43u7afl3	39	24	genetic	genetic	JJ
cord-342936-43u7afl3	39	25	polypeptide	polypeptide	NN
cord-342936-43u7afl3	39	26	background	background	NN
cord-342936-43u7afl3	39	27	.	.	.
cord-342936-43u7afl3	40	1	This	this	DT
cord-342936-43u7afl3	40	2	results	result	VBZ
cord-342936-43u7afl3	40	3	in	in	IN
cord-342936-43u7afl3	40	4	the	the	DT
cord-342936-43u7afl3	40	5	creation	creation	NN
cord-342936-43u7afl3	40	6	of	of	IN
cord-342936-43u7afl3	40	7	new	new	JJ
cord-342936-43u7afl3	40	8	functionalities	functionality	NNS
cord-342936-43u7afl3	40	9	and	and	CC
cord-342936-43u7afl3	40	10	specificities	specificity	NNS
cord-342936-43u7afl3	40	11	8	8	CD
cord-342936-43u7afl3	40	12	,	,	,
cord-342936-43u7afl3	40	13	9	9	CD
cord-342936-43u7afl3	40	14	.	.	.
cord-342936-43u7afl3	41	1	The	the	DT
cord-342936-43u7afl3	41	2	N	N	NNP
cord-342936-43u7afl3	41	3	-	-	HYPH
cord-342936-43u7afl3	41	4	glycans	glycan	NNS
cord-342936-43u7afl3	41	5	may	may	MD
cord-342936-43u7afl3	41	6	also	also	RB
cord-342936-43u7afl3	41	7	have	have	VB
cord-342936-43u7afl3	41	8	an	an	DT
cord-342936-43u7afl3	41	9	important	important	JJ
cord-342936-43u7afl3	41	10	role	role	NN
cord-342936-43u7afl3	41	11	in	in	IN
cord-342936-43u7afl3	41	12	proper	proper	JJ
cord-342936-43u7afl3	41	13	protein	protein	NN
cord-342936-43u7afl3	41	14	folding	folding	NN
cord-342936-43u7afl3	41	15	and	and	CC
cord-342936-43u7afl3	41	16	degradation	degradation	NN
cord-342936-43u7afl3	41	17	10	10	CD
cord-342936-43u7afl3	41	18	,	,	,
cord-342936-43u7afl3	41	19	and	and	CC
cord-342936-43u7afl3	41	20	solubility	solubility	NN
cord-342936-43u7afl3	41	21	,	,	,
cord-342936-43u7afl3	41	22	by	by	IN
cord-342936-43u7afl3	41	23	avoiding	avoid	VBG
cord-342936-43u7afl3	41	24	the	the	DT
cord-342936-43u7afl3	41	25	precipitation	precipitation	NN
cord-342936-43u7afl3	41	26	that	that	WDT
cord-342936-43u7afl3	41	27	is	be	VBZ
cord-342936-43u7afl3	41	28	caused	cause	VBN
cord-342936-43u7afl3	41	29	by	by	IN
cord-342936-43u7afl3	41	30	lipophylic	lipophylic	NNP
cord-342936-43u7afl3	41	31	aminoacid	aminoacid	NNP
cord-342936-43u7afl3	41	32	stretches	stretch	VBZ
cord-342936-43u7afl3	41	33	in	in	IN
cord-342936-43u7afl3	41	34	the	the	DT
cord-342936-43u7afl3	41	35	nascent	nascent	JJ
cord-342936-43u7afl3	41	36	polypeptide	polypeptide	NN
cord-342936-43u7afl3	41	37	11	11	CD
cord-342936-43u7afl3	41	38	.	.	.
cord-342936-43u7afl3	42	1	They	-PRON-	PRP
cord-342936-43u7afl3	42	2	also	also	RB
cord-342936-43u7afl3	42	3	control	control	VBP
cord-342936-43u7afl3	42	4	proper	proper	JJ
cord-342936-43u7afl3	42	5	peptidic	peptidic	JJ
cord-342936-43u7afl3	42	6	oligomerization	oligomerization	NN
cord-342936-43u7afl3	42	7	and	and	CC
cord-342936-43u7afl3	42	8	the	the	DT
cord-342936-43u7afl3	42	9	sorting	sorting	NN
cord-342936-43u7afl3	42	10	of	of	IN
cord-342936-43u7afl3	42	11	the	the	DT
cord-342936-43u7afl3	42	12	peptides	peptide	NNS
cord-342936-43u7afl3	42	13	,	,	,
cord-342936-43u7afl3	42	14	as	as	RB
cord-342936-43u7afl3	42	15	well	well	RB
cord-342936-43u7afl3	42	16	as	as	IN
cord-342936-43u7afl3	42	17	peptide	peptide	JJ
cord-342936-43u7afl3	42	18	transport	transport	NN
cord-342936-43u7afl3	42	19	and	and	CC
cord-342936-43u7afl3	42	20	trafficking	trafficking	NN
cord-342936-43u7afl3	42	21	(	(	-LRB-
cord-342936-43u7afl3	42	22	by	by	IN
cord-342936-43u7afl3	42	23	acting	act	VBG
cord-342936-43u7afl3	42	24	as	as	IN
cord-342936-43u7afl3	42	25	universal	universal	NNP
cord-342936-43u7afl3	42	26	'	'	``
cord-342936-43u7afl3	42	27	tags	tag	NNS
cord-342936-43u7afl3	42	28	'	'	''
cord-342936-43u7afl3	42	29	for	for	IN
cord-342936-43u7afl3	42	30	specific	specific	JJ
cord-342936-43u7afl3	42	31	cellular	cellular	JJ
cord-342936-43u7afl3	42	32	lectins	lectin	NNS
cord-342936-43u7afl3	42	33	and	and	CC
cord-342936-43u7afl3	42	34	modifying	modify	VBG
cord-342936-43u7afl3	42	35	enzymes	enzyme	NNS
cord-342936-43u7afl3	42	36	)	)	-RRB-
cord-342936-43u7afl3	42	37	7	7	CD
cord-342936-43u7afl3	42	38	,	,	,
cord-342936-43u7afl3	42	39	9	9	CD
cord-342936-43u7afl3	42	40	,	,	,
cord-342936-43u7afl3	42	41	12	12	CD
cord-342936-43u7afl3	42	42	.	.	.
cord-342936-43u7afl3	43	1	The	the	DT
cord-342936-43u7afl3	43	2	presence	presence	NN
cord-342936-43u7afl3	43	3	of	of	IN
cord-342936-43u7afl3	43	4	a	a	DT
cord-342936-43u7afl3	43	5	glycan	glycan	NN
cord-342936-43u7afl3	43	6	shield	shield	NN
cord-342936-43u7afl3	43	7	on	on	IN
cord-342936-43u7afl3	43	8	the	the	DT
cord-342936-43u7afl3	43	9	peptides	peptide	NNS
cord-342936-43u7afl3	43	10	also	also	RB
cord-342936-43u7afl3	43	11	enables	enable	VBZ
cord-342936-43u7afl3	43	12	the	the	DT
cord-342936-43u7afl3	43	13	efficient	efficient	JJ
cord-342936-43u7afl3	43	14	protection	protection	NN
cord-342936-43u7afl3	43	15	of	of	IN
cord-342936-43u7afl3	43	16	the	the	DT
cord-342936-43u7afl3	43	17	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	43	18	against	against	IN
cord-342936-43u7afl3	43	19	degradation	degradation	NN
cord-342936-43u7afl3	43	20	by	by	IN
cord-342936-43u7afl3	43	21	proteases	protease	NNS
cord-342936-43u7afl3	43	22	.	.	.
cord-342936-43u7afl3	44	1	The	the	DT
cord-342936-43u7afl3	44	2	interactions	interaction	NNS
cord-342936-43u7afl3	44	3	of	of	IN
cord-342936-43u7afl3	44	4	carbohydrates	carbohydrate	NNS
cord-342936-43u7afl3	44	5	with	with	IN
cord-342936-43u7afl3	44	6	cellular	cellular	JJ
cord-342936-43u7afl3	44	7	lectins	lectin	NNS
cord-342936-43u7afl3	44	8	are	be	VBP
cord-342936-43u7afl3	44	9	also	also	RB
cord-342936-43u7afl3	44	10	of	of	IN
cord-342936-43u7afl3	44	11	crucial	crucial	JJ
cord-342936-43u7afl3	44	12	importance	importance	NN
cord-342936-43u7afl3	44	13	for	for	IN
cord-342936-43u7afl3	44	14	the	the	DT
cord-342936-43u7afl3	44	15	efficient	efficient	JJ
cord-342936-43u7afl3	44	16	operation	operation	NN
cord-342936-43u7afl3	44	17	of	of	IN
cord-342936-43u7afl3	44	18	the	the	DT
cord-342936-43u7afl3	44	19	innate	innate	JJ
cord-342936-43u7afl3	44	20	immune	immune	JJ
cord-342936-43u7afl3	44	21	system	system	NN
cord-342936-43u7afl3	44	22	.	.	.
cord-342936-43u7afl3	45	1	Examples	example	NNS
cord-342936-43u7afl3	45	2	include	include	VBP
cord-342936-43u7afl3	45	3	the	the	DT
cord-342936-43u7afl3	45	4	mannose	mannose	NN
cord-342936-43u7afl3	45	5	-	-	HYPH
cord-342936-43u7afl3	45	6	binding	bind	VBG
cord-342936-43u7afl3	45	7	lectin	lectin	NN
cord-342936-43u7afl3	45	8	(	(	-LRB-
cord-342936-43u7afl3	45	9	MBL	MBL	NNP
cord-342936-43u7afl3	45	10	)	)	-RRB-
cord-342936-43u7afl3	45	11	13	13	CD
cord-342936-43u7afl3	45	12	,	,	,
cord-342936-43u7afl3	45	13	DC	DC	NNP
cord-342936-43u7afl3	45	14	-	-	HYPH
cord-342936-43u7afl3	45	15	SIGN	SIGN	NNP
cord-342936-43u7afl3	45	16	14	14	CD
cord-342936-43u7afl3	45	17	,	,	,
cord-342936-43u7afl3	45	18	defensins	defensins	NNP
cord-342936-43u7afl3	45	19	15	15	CD
cord-342936-43u7afl3	45	20	and	and	CC
cord-342936-43u7afl3	45	21	macrophage	macrophage	NN
cord-342936-43u7afl3	45	22	mannose	mannose	JJ
cord-342936-43u7afl3	45	23	receptors	receptor	NNS
cord-342936-43u7afl3	45	24	16	16	CD
cord-342936-43u7afl3	45	25	.	.	.
cord-342936-43u7afl3	46	1	Leukocyte	Leukocyte	NNP
cord-342936-43u7afl3	46	2	interactions	interaction	NNS
cord-342936-43u7afl3	46	3	with	with	IN
cord-342936-43u7afl3	46	4	endothelial	endothelial	JJ
cord-342936-43u7afl3	46	5	cells	cell	NNS
cord-342936-43u7afl3	46	6	represent	represent	VBP
cord-342936-43u7afl3	46	7	a	a	DT
cord-342936-43u7afl3	46	8	well	well	RB
cord-342936-43u7afl3	46	9	-	-	HYPH
cord-342936-43u7afl3	46	10	characterized	characterize	VBN
cord-342936-43u7afl3	46	11	example	example	NN
cord-342936-43u7afl3	46	12	of	of	IN
cord-342936-43u7afl3	46	13	a	a	DT
cord-342936-43u7afl3	46	14	cell	cell	NN
cord-342936-43u7afl3	46	15	-	-	HYPH
cord-342936-43u7afl3	46	16	adhesion	adhesion	NN
cord-342936-43u7afl3	46	17	event	event	NN
cord-342936-43u7afl3	46	18	that	that	WDT
cord-342936-43u7afl3	46	19	depends	depend	VBZ
cord-342936-43u7afl3	46	20	on	on	IN
cord-342936-43u7afl3	46	21	glycan	glycan	NN
cord-342936-43u7afl3	46	22	-	-	HYPH
cord-342936-43u7afl3	46	23	receptor	receptor	NN
cord-342936-43u7afl3	46	24	interactions	interaction	NNS
cord-342936-43u7afl3	46	25	17	17	CD
cord-342936-43u7afl3	46	26	.	.	.
cord-342936-43u7afl3	47	1	Cell	cell	NN
cord-342936-43u7afl3	47	2	-	-	HYPH
cord-342936-43u7afl3	47	3	surface	surface	NN
cord-342936-43u7afl3	47	4	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	47	5	can	can	MD
cord-342936-43u7afl3	47	6	,	,	,
cord-342936-43u7afl3	47	7	therefore	therefore	RB
cord-342936-43u7afl3	47	8	,	,	,
cord-342936-43u7afl3	47	9	mediate	mediate	VB
cord-342936-43u7afl3	47	10	cell	cell	NN
cord-342936-43u7afl3	47	11	adhesion	adhesion	NN
cord-342936-43u7afl3	47	12	and	and	CC
cord-342936-43u7afl3	47	13	signalling	signal	VBG
cord-342936-43u7afl3	47	14	events	event	NNS
cord-342936-43u7afl3	47	15	,	,	,
cord-342936-43u7afl3	47	16	as	as	RB
cord-342936-43u7afl3	47	17	well	well	RB
cord-342936-43u7afl3	47	18	as	as	IN
cord-342936-43u7afl3	47	19	intercellular	intercellular	JJ
cord-342936-43u7afl3	47	20	communication	communication	NN
cord-342936-43u7afl3	47	21	.	.	.
cord-342936-43u7afl3	48	1	As	as	RB
cord-342936-43u7afl3	48	2	well	well	RB
cord-342936-43u7afl3	48	3	as	as	IN
cord-342936-43u7afl3	48	4	mammalian	mammalian	JJ
cord-342936-43u7afl3	48	5	cells	cell	NNS
cord-342936-43u7afl3	48	6	,	,	,
cord-342936-43u7afl3	48	7	many	many	JJ
cord-342936-43u7afl3	48	8	different	different	JJ
cord-342936-43u7afl3	48	9	pathogens	pathogen	NNS
cord-342936-43u7afl3	48	10	,	,	,
cord-342936-43u7afl3	48	11	including	include	VBG
cord-342936-43u7afl3	48	12	viruses	virus	NNS
cord-342936-43u7afl3	48	13	,	,	,
cord-342936-43u7afl3	48	14	bacteria	bacteria	NNS
cord-342936-43u7afl3	48	15	,	,	,
cord-342936-43u7afl3	48	16	fungi	fungus	NNS
cord-342936-43u7afl3	48	17	and	and	CC
cord-342936-43u7afl3	48	18	parasites	parasite	NNS
cord-342936-43u7afl3	48	19	,	,	,
cord-342936-43u7afl3	48	20	also	also	RB
cord-342936-43u7afl3	48	21	use	use	VBP
cord-342936-43u7afl3	48	22	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	48	23	extensively	extensively	RB
cord-342936-43u7afl3	48	24	for	for	IN
cord-342936-43u7afl3	48	25	diverse	diverse	JJ
cord-342936-43u7afl3	48	26	functions	function	NNS
cord-342936-43u7afl3	48	27	,	,	,
cord-342936-43u7afl3	48	28	in	in	IN
cord-342936-43u7afl3	48	29	part	part	NN
cord-342936-43u7afl3	48	30	similar	similar	JJ
cord-342936-43u7afl3	48	31	to	to	IN
cord-342936-43u7afl3	48	32	eukaryotic	eukaryotic	JJ
cord-342936-43u7afl3	48	33	cells	cell	NNS
cord-342936-43u7afl3	48	34	.	.	.
cord-342936-43u7afl3	49	1	However	however	RB
cord-342936-43u7afl3	49	2	,	,	,
cord-342936-43u7afl3	49	3	as	as	IN
cord-342936-43u7afl3	49	4	the	the	DT
cord-342936-43u7afl3	49	5	glycans	glycan	NNS
cord-342936-43u7afl3	49	6	on	on	IN
cord-342936-43u7afl3	49	7	the	the	DT
cord-342936-43u7afl3	49	8	pathogen	pathogen	NN
cord-342936-43u7afl3	49	9	(	(	-LRB-
cord-342936-43u7afl3	49	10	in	in	IN
cord-342936-43u7afl3	49	11	particular	particular	JJ
cord-342936-43u7afl3	49	12	,	,	,
cord-342936-43u7afl3	49	13	viral	viral	JJ
cord-342936-43u7afl3	49	14	-	-	HYPH
cord-342936-43u7afl3	49	15	derived	derive	VBN
cord-342936-43u7afl3	49	16	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	49	17	)	)	-RRB-
cord-342936-43u7afl3	49	18	are	be	VBP
cord-342936-43u7afl3	49	19	produced	produce	VBN
cord-342936-43u7afl3	49	20	by	by	IN
cord-342936-43u7afl3	49	21	the	the	DT
cord-342936-43u7afl3	49	22	cellular	cellular	JJ
cord-342936-43u7afl3	49	23	machinery	machinery	NN
cord-342936-43u7afl3	49	24	,	,	,
cord-342936-43u7afl3	49	25	they	-PRON-	PRP
cord-342936-43u7afl3	49	26	are	be	VBP
cord-342936-43u7afl3	49	27	often	often	RB
cord-342936-43u7afl3	49	28	recognized	recognize	VBN
cord-342936-43u7afl3	49	29	as	as	IN
cord-342936-43u7afl3	49	30	'	'	``
cord-342936-43u7afl3	49	31	self	self	NN
cord-342936-43u7afl3	49	32	'	'	''
cord-342936-43u7afl3	49	33	by	by	IN
cord-342936-43u7afl3	49	34	the	the	DT
cord-342936-43u7afl3	49	35	immune	immune	JJ
cord-342936-43u7afl3	49	36	system	system	NN
cord-342936-43u7afl3	49	37	.	.	.
cord-342936-43u7afl3	50	1	Therefore	therefore	RB
cord-342936-43u7afl3	50	2	,	,	,
cord-342936-43u7afl3	50	3	the	the	DT
cord-342936-43u7afl3	50	4	glycans	glycan	NNS
cord-342936-43u7afl3	50	5	on	on	IN
cord-342936-43u7afl3	50	6	pathogen	pathogen	NN
cord-342936-43u7afl3	50	7	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	50	8	in	in	IN
cord-342936-43u7afl3	50	9	the	the	DT
cord-342936-43u7afl3	50	10	viral	viral	JJ
cord-342936-43u7afl3	50	11	envelope	envelope	NN
cord-342936-43u7afl3	50	12	or	or	CC
cord-342936-43u7afl3	50	13	bacterial	bacterial	JJ
cord-342936-43u7afl3	50	14	cell	cell	NN
cord-342936-43u7afl3	50	15	wall	wall	NN
cord-342936-43u7afl3	50	16	help	help	NN
cord-342936-43u7afl3	50	17	to	to	TO
cord-342936-43u7afl3	50	18	escape	escape	VB
cord-342936-43u7afl3	50	19	recognition	recognition	NN
cord-342936-43u7afl3	50	20	by	by	IN
cord-342936-43u7afl3	50	21	the	the	DT
cord-342936-43u7afl3	50	22	immune	immune	JJ
cord-342936-43u7afl3	50	23	system	system	NN
cord-342936-43u7afl3	50	24	,	,	,
cord-342936-43u7afl3	50	25	and	and	CC
cord-342936-43u7afl3	50	26	the	the	DT
cord-342936-43u7afl3	50	27	subsequent	subsequent	JJ
cord-342936-43u7afl3	50	28	destruction	destruction	NN
cord-342936-43u7afl3	50	29	or	or	CC
cord-342936-43u7afl3	50	30	neutralization	neutralization	NN
cord-342936-43u7afl3	50	31	of	of	IN
cord-342936-43u7afl3	50	32	the	the	DT
cord-342936-43u7afl3	50	33	pathogen	pathogen	NN
cord-342936-43u7afl3	50	34	.	.	.
cord-342936-43u7afl3	51	1	Classes	class	NNS
cord-342936-43u7afl3	51	2	of	of	IN
cord-342936-43u7afl3	51	3	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	51	4	-	-	HYPH
cord-342936-43u7afl3	51	5	binding	bind	VBG
cord-342936-43u7afl3	51	6	agents	agent	NNS
cord-342936-43u7afl3	51	7	Arbitrarily	arbitrarily	RB
cord-342936-43u7afl3	51	8	,	,	,
cord-342936-43u7afl3	51	9	two	two	CD
cord-342936-43u7afl3	51	10	different	different	JJ
cord-342936-43u7afl3	51	11	categories	category	NNS
cord-342936-43u7afl3	51	12	of	of	IN
cord-342936-43u7afl3	51	13	CBAs	cba	NNS
cord-342936-43u7afl3	51	14	can	can	MD
cord-342936-43u7afl3	51	15	be	be	VB
cord-342936-43u7afl3	51	16	distinguished	distinguish	VBN
cord-342936-43u7afl3	51	17	:	:	:
cord-342936-43u7afl3	51	18	lectins	lectin	NNS
cord-342936-43u7afl3	51	19	,	,	,
cord-342936-43u7afl3	51	20	which	which	WDT
cord-342936-43u7afl3	51	21	are	be	VBP
cord-342936-43u7afl3	51	22	proteins	protein	NNS
cord-342936-43u7afl3	51	23	that	that	WDT
cord-342936-43u7afl3	51	24	specifically	specifically	RB
cord-342936-43u7afl3	51	25	recognize	recognize	VBP
cord-342936-43u7afl3	51	26	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	51	27	(	(	-LRB-
cord-342936-43u7afl3	51	28	glycan	glycan	NN
cord-342936-43u7afl3	51	29	)	)	-RRB-
cord-342936-43u7afl3	51	30	structures	structure	NNS
cord-342936-43u7afl3	51	31	,	,	,
cord-342936-43u7afl3	51	32	and	and	CC
cord-342936-43u7afl3	51	33	non	non	JJ
cord-342936-43u7afl3	51	34	-	-	JJ
cord-342936-43u7afl3	51	35	peptidic	peptidic	JJ
cord-342936-43u7afl3	51	36	small	small	JJ
cord-342936-43u7afl3	51	37	-	-	HYPH
cord-342936-43u7afl3	51	38	size	size	NN
cord-342936-43u7afl3	51	39	agents	agent	NNS
cord-342936-43u7afl3	51	40	that	that	WDT
cord-342936-43u7afl3	51	41	may	may	MD
cord-342936-43u7afl3	51	42	have	have	VB
cord-342936-43u7afl3	51	43	a	a	DT
cord-342936-43u7afl3	51	44	good	good	JJ
cord-342936-43u7afl3	51	45	and	and	CC
cord-342936-43u7afl3	51	46	often	often	RB
cord-342936-43u7afl3	51	47	specific	specific	JJ
cord-342936-43u7afl3	51	48	affinity	affinity	NN
cord-342936-43u7afl3	51	49	for	for	IN
cord-342936-43u7afl3	51	50	monosaccharide	monosaccharide	NN
cord-342936-43u7afl3	51	51	and/or	and/or	CC
cord-342936-43u7afl3	51	52	oligosaccharide	oligosaccharide	NN
cord-342936-43u7afl3	51	53	structures	structure	NNS
cord-342936-43u7afl3	51	54	.	.	.
cord-342936-43u7afl3	52	1	Exposure	exposure	NN
cord-342936-43u7afl3	52	2	of	of	IN
cord-342936-43u7afl3	52	3	CBAs	cba	NNS
cord-342936-43u7afl3	52	4	to	to	IN
cord-342936-43u7afl3	52	5	the	the	DT
cord-342936-43u7afl3	52	6	virus	virus	NN
cord-342936-43u7afl3	52	7	in	in	IN
cord-342936-43u7afl3	52	8	cell	cell	NN
cord-342936-43u7afl3	52	9	culture	culture	NN
cord-342936-43u7afl3	52	10	has	have	VBZ
cord-342936-43u7afl3	52	11	also	also	RB
cord-342936-43u7afl3	52	12	been	be	VBN
cord-342936-43u7afl3	52	13	shown	show	VBN
cord-342936-43u7afl3	52	14	to	to	TO
cord-342936-43u7afl3	52	15	force	force	VB
cord-342936-43u7afl3	52	16	the	the	DT
cord-342936-43u7afl3	52	17	virus	virus	NN
cord-342936-43u7afl3	52	18	to	to	TO
cord-342936-43u7afl3	52	19	delete	delete	VB
cord-342936-43u7afl3	52	20	part	part	NN
cord-342936-43u7afl3	52	21	of	of	IN
cord-342936-43u7afl3	52	22	the	the	DT
cord-342936-43u7afl3	52	23	protective	protective	JJ
cord-342936-43u7afl3	52	24	glycan	glycan	NN
cord-342936-43u7afl3	52	25	shield	shield	NN
cord-342936-43u7afl3	52	26	that	that	WDT
cord-342936-43u7afl3	52	27	is	be	VBZ
cord-342936-43u7afl3	52	28	present	present	JJ
cord-342936-43u7afl3	52	29	on	on	IN
cord-342936-43u7afl3	52	30	its	-PRON-	PRP$
cord-342936-43u7afl3	52	31	envelope	envelope	NN
cord-342936-43u7afl3	52	32	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	52	33	gp120	gp120	NNP
cord-342936-43u7afl3	52	34	.	.	.
cord-342936-43u7afl3	53	1	It	-PRON-	PRP
cord-342936-43u7afl3	53	2	is	be	VBZ
cord-342936-43u7afl3	53	3	assumed	assume	VBN
cord-342936-43u7afl3	53	4	that	that	IN
cord-342936-43u7afl3	53	5	such	such	JJ
cord-342936-43u7afl3	53	6	glycan	glycan	NN
cord-342936-43u7afl3	53	7	deletions	deletion	NNS
cord-342936-43u7afl3	53	8	trigger	trigger	VBP
cord-342936-43u7afl3	53	9	an	an	DT
cord-342936-43u7afl3	53	10	enhanced	enhance	VBN
cord-342936-43u7afl3	53	11	neutralizing	neutralize	VBG
cord-342936-43u7afl3	53	12	antibody	antibody	NN
cord-342936-43u7afl3	53	13	response	response	NN
cord-342936-43u7afl3	53	14	to	to	IN
cord-342936-43u7afl3	53	15	the	the	DT
cord-342936-43u7afl3	53	16	previously	previously	RB
cord-342936-43u7afl3	53	17	hidden	hide	VBN
cord-342936-43u7afl3	53	18	immunogenic	immunogenic	JJ
cord-342936-43u7afl3	53	19	epitopes	epitope	NNS
cord-342936-43u7afl3	53	20	of	of	IN
cord-342936-43u7afl3	53	21	gp120	gp120	NNP
cord-342936-43u7afl3	53	22	and	and	CC
cord-342936-43u7afl3	53	23	possibly	possibly	RB
cord-342936-43u7afl3	53	24	also	also	RB
cord-342936-43u7afl3	53	25	a	a	DT
cord-342936-43u7afl3	53	26	cellular	cellular	JJ
cord-342936-43u7afl3	53	27	immune	immune	JJ
cord-342936-43u7afl3	53	28	response	response	NN
cord-342936-43u7afl3	53	29	.	.	.
cord-342936-43u7afl3	54	1	Parts	part	NNS
cord-342936-43u7afl3	54	2	c	c	NNP
cord-342936-43u7afl3	54	3	and	and	CC
cord-342936-43u7afl3	54	4	d	d	NN
cord-342936-43u7afl3	54	5	reproduced	reproduce	VBN
cord-342936-43u7afl3	54	6	with	with	IN
cord-342936-43u7afl3	54	7	permission	permission	NN
cord-342936-43u7afl3	54	8	from	from	IN
cord-342936-43u7afl3	54	9	REF	REF	NNP
cord-342936-43u7afl3	54	10	.	.	.
cord-342936-43u7afl3	55	1	122	122	CD
cord-342936-43u7afl3	55	2	©	©	NN
cord-342936-43u7afl3	55	3	(	(	-LRB-
cord-342936-43u7afl3	55	4	2006	2006	CD
cord-342936-43u7afl3	55	5	)	)	-RRB-
cord-342936-43u7afl3	55	6	University	University	NNP
cord-342936-43u7afl3	55	7	of	of	IN
cord-342936-43u7afl3	55	8	Amsterdam	Amsterdam	NNP
cord-342936-43u7afl3	55	9	.	.	.
cord-342936-43u7afl3	56	1	CCR5	ccr5	JJ
cord-342936-43u7afl3	56	2	,	,	,
cord-342936-43u7afl3	56	3	chemokine	chemokine	NN
cord-342936-43u7afl3	56	4	receptor	receptor	NN
cord-342936-43u7afl3	56	5	5	5	CD
cord-342936-43u7afl3	56	6	;	;	:
cord-342936-43u7afl3	56	7	LFA-1	LFA-1	NNP
cord-342936-43u7afl3	56	8	,	,	,
cord-342936-43u7afl3	56	9	lymphocyte	lymphocyte	NN
cord-342936-43u7afl3	56	10	function	function	NN
cord-342936-43u7afl3	56	11	-	-	HYPH
cord-342936-43u7afl3	56	12	associated	associate	VBN
cord-342936-43u7afl3	56	13	antigen	antigen	NN
cord-342936-43u7afl3	56	14	1	1	CD
cord-342936-43u7afl3	56	15	.	.	.
cord-342936-43u7afl3	56	16	∼Asn	∼asn	NN
cord-342936-43u7afl3	56	17	-	-	HYPH
cord-342936-43u7afl3	56	18	X	x	NN
cord-342936-43u7afl3	56	19	-	-	JJ
cord-342936-43u7afl3	56	20	Ser	ser	JJ
cord-342936-43u7afl3	57	1	/Thr∼	/Thr∼	.
cord-342936-43u7afl3	58	1	c	c	NNP
cord-342936-43u7afl3	59	1	Syncytium	Syncytium	NNP
cord-342936-43u7afl3	59	2	A	a	DT
cord-342936-43u7afl3	59	3	multinucleated	multinucleated	JJ
cord-342936-43u7afl3	59	4	giant	giant	JJ
cord-342936-43u7afl3	59	5	cell	cell	NN
cord-342936-43u7afl3	59	6	that	that	WDT
cord-342936-43u7afl3	59	7	is	be	VBZ
cord-342936-43u7afl3	59	8	formed	form	VBN
cord-342936-43u7afl3	59	9	following	follow	VBG
cord-342936-43u7afl3	59	10	the	the	DT
cord-342936-43u7afl3	59	11	fusion	fusion	NN
cord-342936-43u7afl3	59	12	of	of	IN
cord-342936-43u7afl3	59	13	infected	infected	JJ
cord-342936-43u7afl3	59	14	cells	cell	NNS
cord-342936-43u7afl3	59	15	expressing	express	VBG
cord-342936-43u7afl3	59	16	HIV	HIV	NNP
cord-342936-43u7afl3	59	17	-	-	HYPH
cord-342936-43u7afl3	59	18	encoded	encode	VBN
cord-342936-43u7afl3	59	19	envelope	envelope	NN
cord-342936-43u7afl3	59	20	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	59	21	and	and	CC
cord-342936-43u7afl3	59	22	uninfected	uninfected	JJ
cord-342936-43u7afl3	59	23	cells	cell	NNS
cord-342936-43u7afl3	59	24	expressing	express	VBG
cord-342936-43u7afl3	59	25	the	the	DT
cord-342936-43u7afl3	59	26	CD4	CD4	NNP
cord-342936-43u7afl3	59	27	co	co	NN
cord-342936-43u7afl3	59	28	-	-	NN
cord-342936-43u7afl3	59	29	receptor	receptor	NN
cord-342936-43u7afl3	59	30	.	.	.
cord-342936-43u7afl3	60	1	The	the	DT
cord-342936-43u7afl3	60	2	resulting	result	VBG
cord-342936-43u7afl3	60	3	syncytium	syncytium	NN
cord-342936-43u7afl3	60	4	subsequently	subsequently	RB
cord-342936-43u7afl3	60	5	undergoes	undergo	VBZ
cord-342936-43u7afl3	60	6	apoptosis	apoptosis	NN
cord-342936-43u7afl3	60	7	.	.	.
cord-342936-43u7afl3	61	1	(	(	-LRB-
cord-342936-43u7afl3	61	2	TABLE	TABLE	NNP
cord-342936-43u7afl3	61	3	1	1	CD
cord-342936-43u7afl3	61	4	)	)	-RRB-
cord-342936-43u7afl3	61	5	.	.	.
cord-342936-43u7afl3	62	1	The	the	DT
cord-342936-43u7afl3	62	2	most	most	RBS
cord-342936-43u7afl3	62	3	well	well	RB
cord-342936-43u7afl3	62	4	-	-	HYPH
cord-342936-43u7afl3	62	5	studied	study	VBN
cord-342936-43u7afl3	62	6	CBA	CBA	NNP
cord-342936-43u7afl3	62	7	is	be	VBZ
cord-342936-43u7afl3	62	8	undoubtedly	undoubtedly	RB
cord-342936-43u7afl3	62	9	cyanovirin	cyanovirin	NNP
cord-342936-43u7afl3	62	10	-	-	HYPH
cord-342936-43u7afl3	62	11	N	N	NNP
cord-342936-43u7afl3	62	12	(	(	-LRB-
cord-342936-43u7afl3	62	13	CV	CV	NNP
cord-342936-43u7afl3	62	14	-	-	HYPH
cord-342936-43u7afl3	62	15	N	N	NNP
cord-342936-43u7afl3	62	16	)	)	-RRB-
cord-342936-43u7afl3	62	17	,	,	,
cord-342936-43u7afl3	62	18	an	an	DT
cord-342936-43u7afl3	62	19	11-kDa	11-kda	CD
cord-342936-43u7afl3	62	20	protein	protein	NN
cord-342936-43u7afl3	62	21	(	(	-LRB-
cord-342936-43u7afl3	62	22	composed	compose	VBN
cord-342936-43u7afl3	62	23	of	of	IN
cord-342936-43u7afl3	62	24	101	101	CD
cord-342936-43u7afl3	62	25	amino	amino	JJ
cord-342936-43u7afl3	62	26	acids	acid	NNS
cord-342936-43u7afl3	62	27	consisting	consist	VBG
cord-342936-43u7afl3	62	28	of	of	IN
cord-342936-43u7afl3	62	29	two	two	CD
cord-342936-43u7afl3	62	30	sequence	sequence	NN
cord-342936-43u7afl3	62	31	repeats	repeat	VBZ
cord-342936-43u7afl3	62	32	)	)	-RRB-
cord-342936-43u7afl3	62	33	originally	originally	RB
cord-342936-43u7afl3	62	34	purified	purify	VBN
cord-342936-43u7afl3	62	35	from	from	IN
cord-342936-43u7afl3	62	36	extracts	extract	NNS
cord-342936-43u7afl3	62	37	of	of	IN
cord-342936-43u7afl3	62	38	the	the	DT
cord-342936-43u7afl3	62	39	cyanobacterium	cyanobacterium	NN
cord-342936-43u7afl3	63	1	Nostoc	Nostoc	NNP
cord-342936-43u7afl3	63	2	ellipsosporum	ellipsosporum	NNP
cord-342936-43u7afl3	63	3	18	18	CD
cord-342936-43u7afl3	63	4	.	.	.
cord-342936-43u7afl3	64	1	The	the	DT
cord-342936-43u7afl3	64	2	elucidation	elucidation	NN
cord-342936-43u7afl3	64	3	of	of	IN
cord-342936-43u7afl3	64	4	CV	CV	NNP
cord-342936-43u7afl3	64	5	-	-	HYPH
cord-342936-43u7afl3	64	6	N	N	NNP
cord-342936-43u7afl3	64	7	crystal	crystal	NN
cord-342936-43u7afl3	64	8	structures	structure	NNS
cord-342936-43u7afl3	64	9	revealed	reveal	VBD
cord-342936-43u7afl3	64	10	the	the	DT
cord-342936-43u7afl3	64	11	existence	existence	NN
cord-342936-43u7afl3	64	12	of	of	IN
cord-342936-43u7afl3	64	13	a	a	DT
cord-342936-43u7afl3	64	14	domain	domain	NN
cord-342936-43u7afl3	64	15	-	-	HYPH
cord-342936-43u7afl3	64	16	swapped	swap	VBN
cord-342936-43u7afl3	64	17	dimer	dimer	NN
cord-342936-43u7afl3	64	18	,	,	,
cord-342936-43u7afl3	64	19	with	with	IN
cord-342936-43u7afl3	64	20	two	two	CD
cord-342936-43u7afl3	64	21	primary	primary	JJ
cord-342936-43u7afl3	64	22	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	64	23	-	-	HYPH
cord-342936-43u7afl3	64	24	binding	bind	VBG
cord-342936-43u7afl3	64	25	sites	site	NNS
cord-342936-43u7afl3	64	26	and	and	CC
cord-342936-43u7afl3	64	27	two	two	CD
cord-342936-43u7afl3	64	28	secondary	secondary	JJ
cord-342936-43u7afl3	64	29	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	64	30	-	-	HYPH
cord-342936-43u7afl3	64	31	binding	bind	VBG
cord-342936-43u7afl3	64	32	sites	site	NNS
cord-342936-43u7afl3	64	33	on	on	IN
cord-342936-43u7afl3	64	34	opposite	opposite	JJ
cord-342936-43u7afl3	64	35	ends	end	NNS
cord-342936-43u7afl3	64	36	of	of	IN
cord-342936-43u7afl3	64	37	the	the	DT
cord-342936-43u7afl3	64	38	dimer	dimer	NN
cord-342936-43u7afl3	64	39	[	[	-LRB-
cord-342936-43u7afl3	64	40	19	19	CD
cord-342936-43u7afl3	64	41	]	]	-RRB-
cord-342936-43u7afl3	64	42	[	[	-LRB-
cord-342936-43u7afl3	64	43	20	20	CD
cord-342936-43u7afl3	64	44	]	]	-RRB-
cord-342936-43u7afl3	64	45	[	[	-LRB-
cord-342936-43u7afl3	64	46	21	21	CD
cord-342936-43u7afl3	64	47	]	]	-RRB-
cord-342936-43u7afl3	64	48	.	.	.
cord-342936-43u7afl3	65	1	The	the	DT
cord-342936-43u7afl3	65	2	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	65	3	-	-	HYPH
cord-342936-43u7afl3	65	4	recognition	recognition	NN
cord-342936-43u7afl3	65	5	sites	site	NNS
cord-342936-43u7afl3	65	6	have	have	VBP
cord-342936-43u7afl3	65	7	a	a	DT
cord-342936-43u7afl3	65	8	binding	binding	JJ
cord-342936-43u7afl3	65	9	geometry	geometry	NN
cord-342936-43u7afl3	65	10	of	of	IN
cord-342936-43u7afl3	65	11	high	high	JJ
cord-342936-43u7afl3	65	12	-	-	HYPH
cord-342936-43u7afl3	65	13	mannose	mannose	NN
cord-342936-43u7afl3	65	14	glycans	glycan	NNS
cord-342936-43u7afl3	65	15	,	,	,
cord-342936-43u7afl3	65	16	in	in	IN
cord-342936-43u7afl3	65	17	particular	particular	JJ
cord-342936-43u7afl3	66	1	α(1,2)-linked	α(1,2)-linke	VBN
cord-342936-43u7afl3	66	2	mannose	mannose	JJ
cord-342936-43u7afl3	66	3	oligomers	oligomer	NNS
cord-342936-43u7afl3	66	4	22	22	CD
cord-342936-43u7afl3	66	5	,	,	,
cord-342936-43u7afl3	66	6	23	23	CD
cord-342936-43u7afl3	66	7	.	.	.
cord-342936-43u7afl3	67	1	A	a	DT
cord-342936-43u7afl3	67	2	monomeric	monomeric	JJ
cord-342936-43u7afl3	67	3	13-kDa	13-kda	CD
cord-342936-43u7afl3	67	4	protein	protein	NN
cord-342936-43u7afl3	67	5	isolated	isolate	VBN
cord-342936-43u7afl3	67	6	from	from	IN
cord-342936-43u7afl3	67	7	the	the	DT
cord-342936-43u7afl3	67	8	unicellular	unicellular	JJ
cord-342936-43u7afl3	67	9	freshwater	freshwater	NN
cord-342936-43u7afl3	67	10	bloom	bloom	NN
cord-342936-43u7afl3	67	11	-	-	HYPH
cord-342936-43u7afl3	67	12	forming	form	VBG
cord-342936-43u7afl3	67	13	cyanobacterium	cyanobacterium	NN
cord-342936-43u7afl3	67	14	Microcystis	Microcystis	NNP
cord-342936-43u7afl3	67	15	viridis	viridis	NN
cord-342936-43u7afl3	67	16	NIES-102	NIES-102	NNP
cord-342936-43u7afl3	67	17	strain	strain	NN
cord-342936-43u7afl3	67	18	(	(	-LRB-
cord-342936-43u7afl3	67	19	Microcystis	microcystis	JJ
cord-342936-43u7afl3	67	20	viridis	viridis	NN
cord-342936-43u7afl3	67	21	lectin	lectin	NN
cord-342936-43u7afl3	67	22	(	(	-LRB-
cord-342936-43u7afl3	67	23	MVL	MVL	NNP
cord-342936-43u7afl3	67	24	)	)	-RRB-
cord-342936-43u7afl3	67	25	)	)	-RRB-
cord-342936-43u7afl3	68	1	24	24	CD
cord-342936-43u7afl3	68	2	was	be	VBD
cord-342936-43u7afl3	68	3	also	also	RB
cord-342936-43u7afl3	68	4	shown	show	VBN
cord-342936-43u7afl3	68	5	to	to	TO
cord-342936-43u7afl3	68	6	be	be	VB
cord-342936-43u7afl3	68	7	composed	compose	VBN
cord-342936-43u7afl3	68	8	of	of	IN
cord-342936-43u7afl3	68	9	two	two	CD
cord-342936-43u7afl3	68	10	tandemly	tandemly	NN
cord-342936-43u7afl3	68	11	repeated	repeat	VBN
cord-342936-43u7afl3	68	12	homologous	homologous	JJ
cord-342936-43u7afl3	68	13	domains	domain	NNS
cord-342936-43u7afl3	68	14	,	,	,
cord-342936-43u7afl3	68	15	with	with	IN
cord-342936-43u7afl3	68	16	specificity	specificity	NN
cord-342936-43u7afl3	68	17	for	for	IN
cord-342936-43u7afl3	68	18	α(1,6)and	α(1,6)and	``
cord-342936-43u7afl3	68	19	possibly	possibly	RB
cord-342936-43u7afl3	68	20	α(1,3)-mannose	α(1,3)-mannose	VBN
cord-342936-43u7afl3	68	21	oligomers	oligomer	NNS
cord-342936-43u7afl3	68	22	.	.	.
cord-342936-43u7afl3	69	1	Its	-PRON-	PRP$
cord-342936-43u7afl3	69	2	smallest	small	JJS
cord-342936-43u7afl3	69	3	target	target	NN
cord-342936-43u7afl3	69	4	is	be	VBZ
cord-342936-43u7afl3	69	5	a	a	DT
cord-342936-43u7afl3	69	6	Man	man	NN
cord-342936-43u7afl3	69	7	2	2	CD
cord-342936-43u7afl3	69	8	GlcNAc	glcnac	NN
cord-342936-43u7afl3	69	9	2	2	CD
cord-342936-43u7afl3	69	10	tetrasaccharide	tetrasaccharide	NN
cord-342936-43u7afl3	69	11	core	core	NN
cord-342936-43u7afl3	69	12	25	25	CD
cord-342936-43u7afl3	69	13	.	.	.
cord-342936-43u7afl3	70	1	Scytovirin	Scytovirin	NNP
cord-342936-43u7afl3	70	2	(	(	-LRB-
cord-342936-43u7afl3	70	3	SVN	SVN	NNP
cord-342936-43u7afl3	70	4	)	)	-RRB-
cord-342936-43u7afl3	70	5	,	,	,
cord-342936-43u7afl3	70	6	a	a	DT
cord-342936-43u7afl3	70	7	9.7-kDa	9.7-kda	CD
cord-342936-43u7afl3	70	8	peptide	peptide	NN
cord-342936-43u7afl3	70	9	,	,	,
cord-342936-43u7afl3	70	10	with	with	IN
cord-342936-43u7afl3	70	11	95	95	CD
cord-342936-43u7afl3	70	12	amino	amino	NN
cord-342936-43u7afl3	70	13	acids	acid	NNS
cord-342936-43u7afl3	70	14	,	,	,
cord-342936-43u7afl3	70	15	has	have	VBZ
cord-342936-43u7afl3	70	16	most	most	RBS
cord-342936-43u7afl3	70	17	recently	recently	RB
cord-342936-43u7afl3	70	18	been	be	VBN
cord-342936-43u7afl3	70	19	isolated	isolate	VBN
cord-342936-43u7afl3	70	20	from	from	IN
cord-342936-43u7afl3	70	21	the	the	DT
cord-342936-43u7afl3	70	22	cyanobacterium	cyanobacterium	NN
cord-342936-43u7afl3	70	23	Scytonema	Scytonema	NNP
cord-342936-43u7afl3	70	24	varium	varium	NNP
cord-342936-43u7afl3	70	25	26	26	CD
cord-342936-43u7afl3	70	26	and	and	CC
cord-342936-43u7afl3	70	27	was	be	VBD
cord-342936-43u7afl3	70	28	shown	show	VBN
cord-342936-43u7afl3	70	29	to	to	TO
cord-342936-43u7afl3	70	30	have	have	VB
cord-342936-43u7afl3	70	31	a	a	DT
cord-342936-43u7afl3	70	32	pronounced	pronounce	VBN
cord-342936-43u7afl3	70	33	affinity	affinity	NN
cord-342936-43u7afl3	70	34	for	for	IN
cord-342936-43u7afl3	70	35	α(1,2)-α(1,6)-mannose	α(1,2)-α(1,6)-mannose	CD
cord-342936-43u7afl3	70	36	trisaccharide	trisaccharide	NNP
cord-342936-43u7afl3	70	37	units	unit	NNS
cord-342936-43u7afl3	70	38	27	27	CD
cord-342936-43u7afl3	70	39	.	.	.
cord-342936-43u7afl3	71	1	Both	both	DT
cord-342936-43u7afl3	71	2	CV	CV	NNP
cord-342936-43u7afl3	71	3	-	-	HYPH
cord-342936-43u7afl3	71	4	N	N	NNP
cord-342936-43u7afl3	71	5	and	and	CC
cord-342936-43u7afl3	71	6	SVN	SVN	NNP
cord-342936-43u7afl3	71	7	inhibit	inhibit	VBP
cord-342936-43u7afl3	71	8	HIV	HIV	NNP
cord-342936-43u7afl3	71	9	infection	infection	NN
cord-342936-43u7afl3	71	10	in	in	IN
cord-342936-43u7afl3	71	11	cell	cell	NN
cord-342936-43u7afl3	71	12	culture	culture	NN
cord-342936-43u7afl3	71	13	,	,	,
cord-342936-43u7afl3	71	14	at	at	IN
cord-342936-43u7afl3	71	15	50	50	CD
cord-342936-43u7afl3	71	16	%	%	NN
cord-342936-43u7afl3	71	17	effective	effective	JJ
cord-342936-43u7afl3	71	18	concentrations	concentration	NNS
cord-342936-43u7afl3	71	19	of	of	IN
cord-342936-43u7afl3	71	20	0.1	0.1	CD
cord-342936-43u7afl3	71	21	and	and	CC
cord-342936-43u7afl3	71	22	0.3	0.3	CD
cord-342936-43u7afl3	71	23	nM	nm	NN
cord-342936-43u7afl3	71	24	,	,	,
cord-342936-43u7afl3	71	25	respectively	respectively	RB
cord-342936-43u7afl3	71	26	.	.	.
cord-342936-43u7afl3	72	1	MVL	MVL	NNP
cord-342936-43u7afl3	72	2	,	,	,
cord-342936-43u7afl3	72	3	however	however	RB
cord-342936-43u7afl3	72	4	,	,	,
cord-342936-43u7afl3	72	5	is	be	VBZ
cord-342936-43u7afl3	72	6	less	less	RBR
cord-342936-43u7afl3	72	7	inhibitory	inhibitory	JJ
cord-342936-43u7afl3	72	8	against	against	IN
cord-342936-43u7afl3	72	9	HIV	HIV	NNP
cord-342936-43u7afl3	72	10	28	28	CD
cord-342936-43u7afl3	72	11	.	.	.
cord-342936-43u7afl3	73	1	A	a	DT
cord-342936-43u7afl3	73	2	CBA	CBA	NNP
cord-342936-43u7afl3	73	3	derived	derive	VBN
cord-342936-43u7afl3	73	4	from	from	IN
cord-342936-43u7afl3	73	5	the	the	DT
cord-342936-43u7afl3	73	6	sea	sea	NN
cord-342936-43u7afl3	73	7	coral	coral	NN
cord-342936-43u7afl3	73	8	Gerardia	Gerardia	NNP
cord-342936-43u7afl3	73	9	savaglia	savaglia	NN
cord-342936-43u7afl3	73	10	(	(	-LRB-
cord-342936-43u7afl3	73	11	GSA	GSA	NNP
cord-342936-43u7afl3	73	12	)	)	-RRB-
cord-342936-43u7afl3	73	13	was	be	VBD
cord-342936-43u7afl3	73	14	one	one	CD
cord-342936-43u7afl3	73	15	of	of	IN
cord-342936-43u7afl3	73	16	the	the	DT
cord-342936-43u7afl3	73	17	first	first	JJ
cord-342936-43u7afl3	73	18	lectins	lectin	NNS
cord-342936-43u7afl3	73	19	isolated	isolate	VBN
cord-342936-43u7afl3	73	20	from	from	IN
cord-342936-43u7afl3	73	21	a	a	DT
cord-342936-43u7afl3	73	22	primitive	primitive	JJ
cord-342936-43u7afl3	73	23	eukaryotic	eukaryotic	JJ
cord-342936-43u7afl3	73	24	organism	organism	NN
cord-342936-43u7afl3	73	25	29	29	CD
cord-342936-43u7afl3	73	26	.	.	.
cord-342936-43u7afl3	74	1	This	this	DT
cord-342936-43u7afl3	74	2	d	d	NN
cord-342936-43u7afl3	74	3	-	-	HYPH
cord-342936-43u7afl3	74	4	mannose	mannose	NN
cord-342936-43u7afl3	74	5	-	-	HYPH
cord-342936-43u7afl3	74	6	specific	specific	JJ
cord-342936-43u7afl3	74	7	CBA	CBA	NNP
cord-342936-43u7afl3	74	8	is	be	VBZ
cord-342936-43u7afl3	74	9	a	a	DT
cord-342936-43u7afl3	74	10	dimer	dimer	NN
cord-342936-43u7afl3	74	11	,	,	,
cord-342936-43u7afl3	74	12	with	with	IN
cord-342936-43u7afl3	74	13	each	each	DT
cord-342936-43u7afl3	74	14	monomer	monomer	NN
cord-342936-43u7afl3	74	15	being	be	VBG
cord-342936-43u7afl3	74	16	14.8	14.8	CD
cord-342936-43u7afl3	74	17	kDa	kDa	NNS
cord-342936-43u7afl3	74	18	,	,	,
cord-342936-43u7afl3	74	19	and	and	CC
cord-342936-43u7afl3	74	20	requiring	require	VBG
cord-342936-43u7afl3	74	21	calcium	calcium	NN
cord-342936-43u7afl3	74	22	to	to	TO
cord-342936-43u7afl3	74	23	preserve	preserve	VB
cord-342936-43u7afl3	74	24	full	full	JJ
cord-342936-43u7afl3	74	25	carbohydratebinding	carbohydratebinding	NN
cord-342936-43u7afl3	74	26	activity	activity	NN
cord-342936-43u7afl3	74	27	.	.	.
cord-342936-43u7afl3	75	1	Actinohivin	Actinohivin	NNP
cord-342936-43u7afl3	75	2	30	30	CD
cord-342936-43u7afl3	75	3	,	,	,
cord-342936-43u7afl3	75	4	derived	derive	VBN
cord-342936-43u7afl3	75	5	from	from	IN
cord-342936-43u7afl3	75	6	the	the	DT
cord-342936-43u7afl3	75	7	actinomycete	actinomycete	JJ
cord-342936-43u7afl3	75	8	Longisporum	Longisporum	NNP
cord-342936-43u7afl3	75	9	alba	alba	NNP
cord-342936-43u7afl3	75	10	(	(	-LRB-
cord-342936-43u7afl3	75	11	a	a	DT
cord-342936-43u7afl3	75	12	12.5-kDa	12.5-kda	CD
cord-342936-43u7afl3	75	13	protein	protein	NN
cord-342936-43u7afl3	75	14	,	,	,
cord-342936-43u7afl3	75	15	with	with	IN
cord-342936-43u7afl3	75	16	114	114	CD
cord-342936-43u7afl3	75	17	amino	amino	JJ
cord-342936-43u7afl3	75	18	acids	acid	NNS
cord-342936-43u7afl3	75	19	)	)	-RRB-
cord-342936-43u7afl3	75	20	,	,	,
cord-342936-43u7afl3	75	21	and	and	CC
cord-342936-43u7afl3	75	22	Griffithsin	Griffithsin	NNP
cord-342936-43u7afl3	75	23	(	(	-LRB-
cord-342936-43u7afl3	75	24	GRFT	GRFT	NNP
cord-342936-43u7afl3	75	25	)	)	-RRB-
cord-342936-43u7afl3	75	26	31	31	CD
cord-342936-43u7afl3	75	27	,	,	,
cord-342936-43u7afl3	75	28	isolated	isolate	VBN
cord-342936-43u7afl3	75	29	from	from	IN
cord-342936-43u7afl3	75	30	the	the	DT
cord-342936-43u7afl3	75	31	red	red	JJ
cord-342936-43u7afl3	75	32	alga	alga	NN
cord-342936-43u7afl3	75	33	Griffithsin	Griffithsin	NNP
cord-342936-43u7afl3	75	34	spp	spp	NNS
cord-342936-43u7afl3	75	35	.	.	.
cord-342936-43u7afl3	76	1	(	(	-LRB-
cord-342936-43u7afl3	76	2	a	a	DT
cord-342936-43u7afl3	76	3	13-kDa	13-kda	CD
cord-342936-43u7afl3	76	4	protein	protein	NN
cord-342936-43u7afl3	76	5	,	,	,
cord-342936-43u7afl3	76	6	with	with	IN
cord-342936-43u7afl3	76	7	121	121	CD
cord-342936-43u7afl3	76	8	amino	amino	JJ
cord-342936-43u7afl3	76	9	acids	acid	NNS
cord-342936-43u7afl3	76	10	)	)	-RRB-
cord-342936-43u7afl3	76	11	,	,	,
cord-342936-43u7afl3	76	12	were	be	VBD
cord-342936-43u7afl3	76	13	also	also	RB
cord-342936-43u7afl3	76	14	recently	recently	RB
cord-342936-43u7afl3	76	15	shown	show	VBN
cord-342936-43u7afl3	76	16	to	to	TO
cord-342936-43u7afl3	76	17	recognize	recognize	VB
cord-342936-43u7afl3	76	18	mannose	mannose	NN
cord-342936-43u7afl3	76	19	-	-	HYPH
cord-342936-43u7afl3	76	20	type	type	NN
cord-342936-43u7afl3	76	21	glycans	glycan	NNS
cord-342936-43u7afl3	76	22	.	.	.
cord-342936-43u7afl3	77	1	Interestingly	interestingly	RB
cord-342936-43u7afl3	77	2	,	,	,
cord-342936-43u7afl3	77	3	the	the	DT
cord-342936-43u7afl3	77	4	calcium	calcium	NN
cord-342936-43u7afl3	77	5	-	-	HYPH
cord-342936-43u7afl3	77	6	independent	independent	JJ
cord-342936-43u7afl3	77	7	GRFT	GRFT	NNP
cord-342936-43u7afl3	77	8	,	,	,
cord-342936-43u7afl3	77	9	a	a	DT
cord-342936-43u7afl3	77	10	dimeric	dimeric	JJ
cord-342936-43u7afl3	77	11	protein	protein	NN
cord-342936-43u7afl3	77	12	with	with	IN
cord-342936-43u7afl3	77	13	four	four	CD
cord-342936-43u7afl3	77	14	α(1,2)-mannose	α(1,2)-mannose	NNP
cord-342936-43u7afl3	77	15	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	77	16	-	-	HYPH
cord-342936-43u7afl3	77	17	binding	bind	VBG
cord-342936-43u7afl3	77	18	domains	domain	NNS
cord-342936-43u7afl3	77	19	(	(	-LRB-
cord-342936-43u7afl3	77	20	CBDs	CBDs	NNP
cord-342936-43u7afl3	77	21	)	)	-RRB-
cord-342936-43u7afl3	77	22	separated	separate	VBN
cord-342936-43u7afl3	77	23	by	by	IN
cord-342936-43u7afl3	77	24	short	short	JJ
cord-342936-43u7afl3	77	25	linker	linker	NN
cord-342936-43u7afl3	77	26	sequences	sequence	NNS
cord-342936-43u7afl3	77	27	,	,	,
cord-342936-43u7afl3	77	28	has	have	VBZ
cord-342936-43u7afl3	77	29	no	no	DT
cord-342936-43u7afl3	77	30	homology	homology	NN
cord-342936-43u7afl3	77	31	to	to	IN
cord-342936-43u7afl3	77	32	any	any	DT
cord-342936-43u7afl3	77	33	other	other	JJ
cord-342936-43u7afl3	77	34	primary	primary	JJ
cord-342936-43u7afl3	77	35	amino	amino	NN
cord-342936-43u7afl3	77	36	-	-	HYPH
cord-342936-43u7afl3	77	37	acid	acid	NN
cord-342936-43u7afl3	77	38	sequence	sequence	NN
cord-342936-43u7afl3	77	39	that	that	WDT
cord-342936-43u7afl3	77	40	has	have	VBZ
cord-342936-43u7afl3	77	41	been	be	VBN
cord-342936-43u7afl3	77	42	found	find	VBN
cord-342936-43u7afl3	77	43	so	so	RB
cord-342936-43u7afl3	77	44	far	far	RB
cord-342936-43u7afl3	77	45	31	31	CD
cord-342936-43u7afl3	77	46	.	.	.
cord-342936-43u7afl3	78	1	GSA	GSA	NNP
cord-342936-43u7afl3	78	2	showed	show	VBD
cord-342936-43u7afl3	78	3	complete	complete	JJ
cord-342936-43u7afl3	78	4	suppression	suppression	NN
cord-342936-43u7afl3	78	5	of	of	IN
cord-342936-43u7afl3	78	6	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	78	7	infection	infection	NN
cord-342936-43u7afl3	78	8	in	in	IN
cord-342936-43u7afl3	78	9	the	the	DT
cord-342936-43u7afl3	78	10	H9	H9	NNP
cord-342936-43u7afl3	78	11	cell	cell	NN
cord-342936-43u7afl3	78	12	line	line	NN
cord-342936-43u7afl3	78	13	at	at	IN
cord-342936-43u7afl3	78	14	a	a	DT
cord-342936-43u7afl3	78	15	concentration	concentration	NN
cord-342936-43u7afl3	78	16	of	of	IN
cord-342936-43u7afl3	78	17	0.2	0.2	CD
cord-342936-43u7afl3	78	18	µM.	µm.	JJ
cord-342936-43u7afl3	79	1	At	at	IN
cord-342936-43u7afl3	79	2	the	the	DT
cord-342936-43u7afl3	79	3	same	same	JJ
cord-342936-43u7afl3	79	4	concentration	concentration	NN
cord-342936-43u7afl3	79	5	,	,	,
cord-342936-43u7afl3	79	6	syncytia	syncytia	NN
cord-342936-43u7afl3	79	7	formation	formation	NN
cord-342936-43u7afl3	79	8	between	between	IN
cord-342936-43u7afl3	79	9	H9	H9	NNP
cord-342936-43u7afl3	79	10	and	and	CC
cord-342936-43u7afl3	79	11	HIV-1-persistently	hiv-1-persistently	RB
cord-342936-43u7afl3	79	12	infected	infect	VBD
cord-342936-43u7afl3	79	13	Jurkat	Jurkat	NNP
cord-342936-43u7afl3	79	14	cells	cell	NNS
cord-342936-43u7afl3	79	15	was	be	VBD
cord-342936-43u7afl3	79	16	blocked	block	VBN
cord-342936-43u7afl3	79	17	32	32	CD
cord-342936-43u7afl3	79	18	.	.	.
cord-342936-43u7afl3	80	1	Actinohivin	Actinohivin	NNP
cord-342936-43u7afl3	80	2	inhibits	inhibit	VBZ
cord-342936-43u7afl3	80	3	both	both	DT
cord-342936-43u7afl3	80	4	T	t	NN
cord-342936-43u7afl3	80	5	-	-	HYPH
cord-342936-43u7afl3	80	6	cell	cell	NN
cord-342936-43u7afl3	80	7	and	and	CC
cord-342936-43u7afl3	80	8	macrophage	macrophage	NN
cord-342936-43u7afl3	80	9	infection	infection	NN
cord-342936-43u7afl3	80	10	by	by	IN
cord-342936-43u7afl3	80	11	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	80	12	at	at	IN
cord-342936-43u7afl3	80	13	60	60	CD
cord-342936-43u7afl3	80	14	to	to	IN
cord-342936-43u7afl3	80	15	700	700	CD
cord-342936-43u7afl3	80	16	nM	nm	CD
cord-342936-43u7afl3	80	17	concentrations	concentration	NNS
cord-342936-43u7afl3	80	18	in	in	IN
cord-342936-43u7afl3	80	19	cell	cell	NN
cord-342936-43u7afl3	80	20	culture	culture	NN
cord-342936-43u7afl3	80	21	33	33	CD
cord-342936-43u7afl3	80	22	;	;	:
cord-342936-43u7afl3	80	23	GRFT	grft	NN
cord-342936-43u7afl3	80	24	is	be	VBZ
cord-342936-43u7afl3	80	25	exquisitely	exquisitely	RB
cord-342936-43u7afl3	80	26	active	active	JJ
cord-342936-43u7afl3	80	27	against	against	IN
cord-342936-43u7afl3	80	28	CXC	CXC	NNP
cord-342936-43u7afl3	80	29	-	-	HYPH
cord-342936-43u7afl3	80	30	chemokine	chemokine	NN
cord-342936-43u7afl3	80	31	receptor	receptor	NN
cord-342936-43u7afl3	80	32	4	4	CD
cord-342936-43u7afl3	81	1	(	(	-LRB-
cord-342936-43u7afl3	81	2	CXCR4)-tropic	cxcr4)-tropic	VB
cord-342936-43u7afl3	81	3	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	81	4	(	(	-LRB-
cord-342936-43u7afl3	81	5	X4	X4	NNP
cord-342936-43u7afl3	81	6	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	81	7	)	)	-RRB-
cord-342936-43u7afl3	81	8	and	and	CC
cord-342936-43u7afl3	81	9	CC	cc	NN
cord-342936-43u7afl3	81	10	-	-	HYPH
cord-342936-43u7afl3	81	11	chemokine	chemokine	NN
cord-342936-43u7afl3	81	12	receptor	receptor	NN
cord-342936-43u7afl3	81	13	5	5	CD
cord-342936-43u7afl3	81	14	(	(	-LRB-
cord-342936-43u7afl3	81	15	CCR5)-tropic	CCR5)-tropic	NNP
cord-342936-43u7afl3	81	16	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	81	17	(	(	-LRB-
cord-342936-43u7afl3	81	18	R5	R5	NNP
cord-342936-43u7afl3	81	19	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	81	20	)	)	-RRB-
cord-342936-43u7afl3	81	21	isolates	isolate	VBZ
cord-342936-43u7afl3	81	22	,	,	,
cord-342936-43u7afl3	81	23	with	with	IN
cord-342936-43u7afl3	81	24	EC	EC	NNP
cord-342936-43u7afl3	81	25	50	50	CD
cord-342936-43u7afl3	81	26	s	s	NNPS
cord-342936-43u7afl3	81	27	ranging	range	VBG
cord-342936-43u7afl3	81	28	from	from	IN
cord-342936-43u7afl3	81	29	0.04	0.04	CD
cord-342936-43u7afl3	81	30	to	to	IN
cord-342936-43u7afl3	81	31	0.63	0.63	CD
cord-342936-43u7afl3	81	32	nM	nm	CD
cord-342936-43u7afl3	81	33	31	31	CD
cord-342936-43u7afl3	81	34	.	.	.
cord-342936-43u7afl3	82	1	CBAs	cba	NNS
cord-342936-43u7afl3	82	2	that	that	WDT
cord-342936-43u7afl3	82	3	have	have	VBP
cord-342936-43u7afl3	82	4	a	a	DT
cord-342936-43u7afl3	82	5	broad	broad	JJ
cord-342936-43u7afl3	82	6	array	array	NN
cord-342936-43u7afl3	82	7	of	of	IN
cord-342936-43u7afl3	82	8	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	82	9	specificities	specificity	NNS
cord-342936-43u7afl3	82	10	,	,	,
cord-342936-43u7afl3	82	11	including	include	VBG
cord-342936-43u7afl3	82	12	mannose	mannose	NN
cord-342936-43u7afl3	82	13	,	,	,
cord-342936-43u7afl3	82	14	glucose	glucose	NN
cord-342936-43u7afl3	82	15	,	,	,
cord-342936-43u7afl3	82	16	galactose	galactose	NN
cord-342936-43u7afl3	82	17	,	,	,
cord-342936-43u7afl3	82	18	fucose	fucose	JJ
cord-342936-43u7afl3	82	19	,	,	,
cord-342936-43u7afl3	82	20	sialic	sialic	JJ
cord-342936-43u7afl3	82	21	acid	acid	NN
cord-342936-43u7afl3	82	22	,	,	,
cord-342936-43u7afl3	82	23	GlcNAc	GlcNAc	NNP
cord-342936-43u7afl3	82	24	and	and	CC
cord-342936-43u7afl3	82	25	GalNAc	GalNAc	NNP
cord-342936-43u7afl3	82	26	oligomers	oligomer	NNS
cord-342936-43u7afl3	82	27	,	,	,
cord-342936-43u7afl3	82	28	are	be	VBP
cord-342936-43u7afl3	82	29	prevalent	prevalent	JJ
cord-342936-43u7afl3	82	30	in	in	IN
cord-342936-43u7afl3	82	31	many	many	JJ
cord-342936-43u7afl3	82	32	plant	plant	NN
cord-342936-43u7afl3	82	33	families	family	NNS
cord-342936-43u7afl3	82	34	.	.	.
cord-342936-43u7afl3	83	1	Monomer	monomer	NN
cord-342936-43u7afl3	83	2	and	and	CC
cord-342936-43u7afl3	83	3	dimer	dimer	NN
cord-342936-43u7afl3	83	4	forms	form	NNS
cord-342936-43u7afl3	83	5	of	of	IN
cord-342936-43u7afl3	83	6	plant	plant	NN
cord-342936-43u7afl3	83	7	lectins	lectin	NNS
cord-342936-43u7afl3	83	8	predominate	predominate	VBP
cord-342936-43u7afl3	83	9	,	,	,
cord-342936-43u7afl3	83	10	but	but	CC
cord-342936-43u7afl3	83	11	trimer	trimer	NN
cord-342936-43u7afl3	83	12	,	,	,
cord-342936-43u7afl3	83	13	tetramer	tetramer	NN
cord-342936-43u7afl3	83	14	and	and	CC
cord-342936-43u7afl3	83	15	even	even	RB
cord-342936-43u7afl3	83	16	octamer	octamer	NN
cord-342936-43u7afl3	83	17	plant	plant	NN
cord-342936-43u7afl3	83	18	lectins	lectin	NNS
cord-342936-43u7afl3	83	19	exist	exist	VBP
cord-342936-43u7afl3	83	20	that	that	DT
cord-342936-43u7afl3	83	21	lead	lead	VBP
cord-342936-43u7afl3	83	22	to	to	IN
cord-342936-43u7afl3	83	23	quaternary	quaternary	JJ
cord-342936-43u7afl3	83	24	protein	protein	NN
cord-342936-43u7afl3	83	25	complexes	complex	NNS
cord-342936-43u7afl3	83	26	that	that	WDT
cord-342936-43u7afl3	83	27	have	have	VBP
cord-342936-43u7afl3	83	28	relatively	relatively	RB
cord-342936-43u7afl3	83	29	high	high	JJ
cord-342936-43u7afl3	83	30	molecular	molecular	JJ
cord-342936-43u7afl3	83	31	weights	weight	NNS
cord-342936-43u7afl3	83	32	(	(	-LRB-
cord-342936-43u7afl3	83	33	for	for	IN
cord-342936-43u7afl3	83	34	an	an	DT
cord-342936-43u7afl3	83	35	overview	overview	NN
cord-342936-43u7afl3	83	36	,	,	,
cord-342936-43u7afl3	83	37	see	see	VB
cord-342936-43u7afl3	83	38	REFS	ref	NNS
cord-342936-43u7afl3	83	39	34	34	CD
cord-342936-43u7afl3	83	40	,	,	,
cord-342936-43u7afl3	83	41	35	35	CD
cord-342936-43u7afl3	83	42	)	)	-RRB-
cord-342936-43u7afl3	83	43	.	.	.
cord-342936-43u7afl3	84	1	The	the	DT
cord-342936-43u7afl3	84	2	crystal	crystal	NN
cord-342936-43u7afl3	84	3	structures	structure	NNS
cord-342936-43u7afl3	84	4	of	of	IN
cord-342936-43u7afl3	84	5	a	a	DT
cord-342936-43u7afl3	84	6	number	number	NN
cord-342936-43u7afl3	84	7	of	of	IN
cord-342936-43u7afl3	84	8	plant	plant	NN
cord-342936-43u7afl3	84	9	lectins	lectin	NNS
cord-342936-43u7afl3	84	10	in	in	IN
cord-342936-43u7afl3	84	11	complex	complex	NN
cord-342936-43u7afl3	84	12	with	with	IN
cord-342936-43u7afl3	84	13	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	84	14	oligomers	oligomer	NNS
cord-342936-43u7afl3	84	15	have	have	VBP
cord-342936-43u7afl3	84	16	been	be	VBN
cord-342936-43u7afl3	84	17	determined	determine	VBN
cord-342936-43u7afl3	84	18	,	,	,
cord-342936-43u7afl3	84	19	such	such	JJ
cord-342936-43u7afl3	84	20	as	as	IN
cord-342936-43u7afl3	84	21	the	the	DT
cord-342936-43u7afl3	84	22	mannose	mannose	NN
cord-342936-43u7afl3	84	23	-	-	HYPH
cord-342936-43u7afl3	84	24	specific	specific	JJ
cord-342936-43u7afl3	84	25	lectin	lectin	NN
cord-342936-43u7afl3	84	26	from	from	IN
cord-342936-43u7afl3	84	27	Galanthus	Galanthus	NNP
cord-342936-43u7afl3	84	28	nivalis	nivalis	NN
cord-342936-43u7afl3	84	29	(	(	-LRB-
cord-342936-43u7afl3	84	30	GNA	GNA	NNP
cord-342936-43u7afl3	84	31	)	)	-RRB-
cord-342936-43u7afl3	85	1	36	36	CD
cord-342936-43u7afl3	85	2	Examples	example	NNS
cord-342936-43u7afl3	85	3	of	of	IN
cord-342936-43u7afl3	85	4	the	the	DT
cord-342936-43u7afl3	85	5	structural	structural	JJ
cord-342936-43u7afl3	85	6	composition	composition	NN
cord-342936-43u7afl3	85	7	of	of	IN
cord-342936-43u7afl3	85	8	high	high	JJ
cord-342936-43u7afl3	85	9	-	-	HYPH
cord-342936-43u7afl3	85	10	mannose	mannose	NN
cord-342936-43u7afl3	85	11	-	-	HYPH
cord-342936-43u7afl3	85	12	type	type	NN
cord-342936-43u7afl3	85	13	N	n	NN
cord-342936-43u7afl3	85	14	-	-	HYPH
cord-342936-43u7afl3	85	15	glycans	glycan	NNS
cord-342936-43u7afl3	85	16	.	.	.
cord-342936-43u7afl3	86	1	a	a	DT
cord-342936-43u7afl3	86	2	|	|	NNP
cord-342936-43u7afl3	86	3	Tri	Tri	NNP
cord-342936-43u7afl3	86	4	-	-	HYPH
cord-342936-43u7afl3	86	5	antennary	antennary	JJ
cord-342936-43u7afl3	86	6	complex	complex	JJ
cord-342936-43u7afl3	86	7	-	-	HYPH
cord-342936-43u7afl3	86	8	type	type	NN
cord-342936-43u7afl3	86	9	N	n	NN
cord-342936-43u7afl3	86	10	-	-	HYPH
cord-342936-43u7afl3	86	11	glycans	glycan	NNS
cord-342936-43u7afl3	86	12	.	.	.
cord-342936-43u7afl3	87	1	b	b	LS
cord-342936-43u7afl3	87	2	|	|	NNP
cord-342936-43u7afl3	87	3	Hybrid	Hybrid	NNP
cord-342936-43u7afl3	87	4	-	-	HYPH
cord-342936-43u7afl3	87	5	type	type	NN
cord-342936-43u7afl3	87	6	N	n	NN
cord-342936-43u7afl3	87	7	-	-	HYPH
cord-342936-43u7afl3	87	8	glycans	glycan	NNS
cord-342936-43u7afl3	87	9	.	.	.
cord-342936-43u7afl3	88	1	c	c	NNP
cord-342936-43u7afl3	88	2	|	|	:
cord-342936-43u7afl3	88	3	High	high	JJ
cord-342936-43u7afl3	88	4	-	-	HYPH
cord-342936-43u7afl3	88	5	mannose	mannose	NN
cord-342936-43u7afl3	88	6	-	-	HYPH
cord-342936-43u7afl3	88	7	type	type	NN
cord-342936-43u7afl3	88	8	N	n	NN
cord-342936-43u7afl3	88	9	-	-	HYPH
cord-342936-43u7afl3	88	10	glycans	glycan	NNS
cord-342936-43u7afl3	88	11	that	that	WDT
cord-342936-43u7afl3	88	12	are	be	VBP
cord-342936-43u7afl3	88	13	abundantly	abundantly	RB
cord-342936-43u7afl3	88	14	present	present	JJ
cord-342936-43u7afl3	88	15	on	on	IN
cord-342936-43u7afl3	88	16	the	the	DT
cord-342936-43u7afl3	88	17	envelope	envelope	NN
cord-342936-43u7afl3	88	18	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	88	19	gp120	gp120	NN
cord-342936-43u7afl3	88	20	of	of	IN
cord-342936-43u7afl3	88	21	HIV	HIV	NNP
cord-342936-43u7afl3	88	22	,	,	,
cord-342936-43u7afl3	88	23	but	but	CC
cord-342936-43u7afl3	88	24	are	be	VBP
cord-342936-43u7afl3	88	25	rare	rare	JJ
cord-342936-43u7afl3	88	26	on	on	IN
cord-342936-43u7afl3	88	27	mammalian	mammalian	JJ
cord-342936-43u7afl3	88	28	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	88	29	.	.	.
cord-342936-43u7afl3	89	1	Besides	besides	IN
cord-342936-43u7afl3	89	2	high	high	JJ
cord-342936-43u7afl3	89	3	-	-	HYPH
cord-342936-43u7afl3	89	4	mannose	mannose	NN
cord-342936-43u7afl3	89	5	-	-	HYPH
cord-342936-43u7afl3	89	6	type	type	NN
cord-342936-43u7afl3	89	7	N	n	NN
cord-342936-43u7afl3	89	8	-	-	HYPH
cord-342936-43u7afl3	89	9	glycans	glycan	NNS
cord-342936-43u7afl3	89	10	,	,	,
cord-342936-43u7afl3	89	11	the	the	DT
cord-342936-43u7afl3	89	12	complex	complex	JJ
cord-342936-43u7afl3	89	13	-	-	HYPH
cord-342936-43u7afl3	89	14	type	type	NN
cord-342936-43u7afl3	89	15	and	and	CC
cord-342936-43u7afl3	89	16	hybrid	hybrid	JJ
cord-342936-43u7afl3	89	17	-	-	HYPH
cord-342936-43u7afl3	89	18	type	type	NN
cord-342936-43u7afl3	89	19	N	n	NN
cord-342936-43u7afl3	89	20	-	-	HYPH
cord-342936-43u7afl3	89	21	glycans	glycan	NNS
cord-342936-43u7afl3	89	22	are	be	VBP
cord-342936-43u7afl3	89	23	also	also	RB
cord-342936-43u7afl3	89	24	present	present	JJ
cord-342936-43u7afl3	89	25	on	on	IN
cord-342936-43u7afl3	89	26	gp120	gp120	NNP
cord-342936-43u7afl3	89	27	.	.	.
cord-342936-43u7afl3	90	1	Asn	Asn	NNP
cord-342936-43u7afl3	90	2	,	,	,
cord-342936-43u7afl3	90	3	asparagine	asparagine	NN
cord-342936-43u7afl3	90	4	;	;	:
cord-342936-43u7afl3	90	5	Fuc	Fuc	NNP
cord-342936-43u7afl3	90	6	,	,	,
cord-342936-43u7afl3	90	7	fucose	fucose	JJ
cord-342936-43u7afl3	90	8	;	;	:
cord-342936-43u7afl3	90	9	Gal	Gal	NNP
cord-342936-43u7afl3	90	10	,	,	,
cord-342936-43u7afl3	90	11	Galactose	galactose	NN
cord-342936-43u7afl3	90	12	;	;	:
cord-342936-43u7afl3	90	13	GlcNAc	GlcNAc	NNP
cord-342936-43u7afl3	90	14	,	,	,
cord-342936-43u7afl3	90	15	N	n	CD
cord-342936-43u7afl3	90	16	-	-	HYPH
cord-342936-43u7afl3	90	17	acetylglucosamine	acetylglucosamine	NNP
cord-342936-43u7afl3	90	18	;	;	:
cord-342936-43u7afl3	90	19	Man	man	NN
cord-342936-43u7afl3	90	20	,	,	,
cord-342936-43u7afl3	90	21	mannose	mannose	NN
cord-342936-43u7afl3	90	22	;	;	:
cord-342936-43u7afl3	90	23	SA	SA	NNP
cord-342936-43u7afl3	90	24	,	,	,
cord-342936-43u7afl3	90	25	sialic	sialic	JJ
cord-342936-43u7afl3	90	26	acid	acid	NN
cord-342936-43u7afl3	90	27	;	;	:
cord-342936-43u7afl3	90	28	Ser	Ser	NNP
cord-342936-43u7afl3	90	29	,	,	,
cord-342936-43u7afl3	90	30	serine	serine	NN
cord-342936-43u7afl3	90	31	;	;	:
cord-342936-43u7afl3	90	32	Thr	Thr	NNP
cord-342936-43u7afl3	90	33	,	,	,
cord-342936-43u7afl3	90	34	threonine	threonine	NN
cord-342936-43u7afl3	90	35	;	;	:
cord-342936-43u7afl3	90	36	X	x	NN
cord-342936-43u7afl3	90	37	,	,	,
cord-342936-43u7afl3	90	38	any	any	DT
cord-342936-43u7afl3	90	39	amino	amino	NN
cord-342936-43u7afl3	90	40	acid	acid	NN
cord-342936-43u7afl3	90	41	except	except	IN
cord-342936-43u7afl3	90	42	proline	proline	NN
cord-342936-43u7afl3	90	43	.	.	.
cord-342936-43u7afl3	91	1	CBAs	cba	NNS
cord-342936-43u7afl3	91	2	have	have	VBP
cord-342936-43u7afl3	91	3	also	also	RB
cord-342936-43u7afl3	91	4	been	be	VBN
cord-342936-43u7afl3	91	5	isolated	isolate	VBN
cord-342936-43u7afl3	91	6	from	from	IN
cord-342936-43u7afl3	91	7	invertebrates	invertebrate	NNS
cord-342936-43u7afl3	91	8	,	,	,
cord-342936-43u7afl3	91	9	such	such	JJ
cord-342936-43u7afl3	91	10	as	as	IN
cord-342936-43u7afl3	91	11	CVL	CVL	NNP
cord-342936-43u7afl3	91	12	from	from	IN
cord-342936-43u7afl3	91	13	Chaetopterus	Chaetopterus	NNP
cord-342936-43u7afl3	91	14	variapedatus	variapedatus	NNP
cord-342936-43u7afl3	91	15	42	42	CD
cord-342936-43u7afl3	91	16	or	or	CC
cord-342936-43u7afl3	91	17	Mermaid	Mermaid	NNP
cord-342936-43u7afl3	91	18	from	from	IN
cord-342936-43u7afl3	91	19	Laxus	Laxus	NNP
cord-342936-43u7afl3	91	20	oneistus	oneistus	NNP
cord-342936-43u7afl3	91	21	43	43	CD
cord-342936-43u7afl3	91	22	.	.	.
cord-342936-43u7afl3	92	1	Whereas	whereas	IN
cord-342936-43u7afl3	92	2	CVL	CVL	NNP
cord-342936-43u7afl3	92	3	has	have	VBZ
cord-342936-43u7afl3	92	4	β	β	NN
cord-342936-43u7afl3	92	5	-	-	HYPH
cord-342936-43u7afl3	92	6	galactose	galactose	NN
cord-342936-43u7afl3	92	7	specificity	specificity	NN
cord-342936-43u7afl3	92	8	,	,	,
cord-342936-43u7afl3	92	9	Mermaid	Mermaid	NNP
cord-342936-43u7afl3	92	10	is	be	VBZ
cord-342936-43u7afl3	92	11	a	a	DT
cord-342936-43u7afl3	92	12	calcium	calcium	NN
cord-342936-43u7afl3	92	13	-	-	HYPH
cord-342936-43u7afl3	92	14	dependent	dependent	JJ
cord-342936-43u7afl3	92	15	mannose	mannose	NN
cord-342936-43u7afl3	92	16	-	-	HYPH
cord-342936-43u7afl3	92	17	specific	specific	JJ
cord-342936-43u7afl3	92	18	CBA	CBA	NNP
cord-342936-43u7afl3	92	19	.	.	.
cord-342936-43u7afl3	93	1	Interestingly	interestingly	RB
cord-342936-43u7afl3	93	2	,	,	,
cord-342936-43u7afl3	93	3	Mermaid	Mermaid	NNP
cord-342936-43u7afl3	93	4	was	be	VBD
cord-342936-43u7afl3	93	5	reported	report	VBN
cord-342936-43u7afl3	93	6	to	to	TO
cord-342936-43u7afl3	93	7	have	have	VB
cord-342936-43u7afl3	93	8	a	a	DT
cord-342936-43u7afl3	93	9	strong	strong	JJ
cord-342936-43u7afl3	93	10	structural	structural	JJ
cord-342936-43u7afl3	93	11	resemblance	resemblance	NN
cord-342936-43u7afl3	93	12	to	to	IN
cord-342936-43u7afl3	93	13	mammalian	mammalian	JJ
cord-342936-43u7afl3	93	14	DC	DC	NNP
cord-342936-43u7afl3	93	15	-	-	HYPH
cord-342936-43u7afl3	93	16	SIGN	SIGN	NNP
cord-342936-43u7afl3	93	17	43	43	CD
cord-342936-43u7afl3	93	18	.	.	.
cord-342936-43u7afl3	94	1	The	the	DT
cord-342936-43u7afl3	94	2	antiviral	antiviral	JJ
cord-342936-43u7afl3	94	3	activity	activity	NN
cord-342936-43u7afl3	94	4	of	of	IN
cord-342936-43u7afl3	94	5	CVL	CVL	NNP
cord-342936-43u7afl3	94	6	against	against	IN
cord-342936-43u7afl3	94	7	HIV	HIV	NNP
cord-342936-43u7afl3	94	8	is	be	VBZ
cord-342936-43u7afl3	94	9	in	in	IN
cord-342936-43u7afl3	94	10	the	the	DT
cord-342936-43u7afl3	94	11	range	range	NN
cord-342936-43u7afl3	94	12	of	of	IN
cord-342936-43u7afl3	94	13	0.004	0.004	CD
cord-342936-43u7afl3	94	14	-	-	HYPH
cord-342936-43u7afl3	94	15	0.06	0.06	CD
cord-342936-43u7afl3	94	16	µM	µm	CD
cord-342936-43u7afl3	94	17	42	42	CD
cord-342936-43u7afl3	94	18	;	;	:
cord-342936-43u7afl3	94	19	the	the	DT
cord-342936-43u7afl3	94	20	anti	anti	JJ
cord-342936-43u7afl3	94	21	-	-	JJ
cord-342936-43u7afl3	94	22	HIV	hiv	JJ
cord-342936-43u7afl3	94	23	activity	activity	NN
cord-342936-43u7afl3	94	24	of	of	IN
cord-342936-43u7afl3	94	25	Mermaid	Mermaid	NNP
cord-342936-43u7afl3	94	26	has	have	VBZ
cord-342936-43u7afl3	94	27	not	not	RB
cord-342936-43u7afl3	94	28	yet	yet	RB
cord-342936-43u7afl3	94	29	been	be	VBN
cord-342936-43u7afl3	94	30	reported	report	VBN
cord-342936-43u7afl3	94	31	.	.	.
cord-342936-43u7afl3	95	1	Mammalians	mammalian	NNS
cord-342936-43u7afl3	95	2	also	also	RB
cord-342936-43u7afl3	95	3	have	have	VBP
cord-342936-43u7afl3	95	4	several	several	JJ
cord-342936-43u7afl3	95	5	types	type	NNS
cord-342936-43u7afl3	95	6	of	of	IN
cord-342936-43u7afl3	95	7	CBA	CBA	NNP
cord-342936-43u7afl3	95	8	.	.	.
cord-342936-43u7afl3	96	1	MBL	MBL	NNP
cord-342936-43u7afl3	96	2	is	be	VBZ
cord-342936-43u7afl3	96	3	a	a	DT
cord-342936-43u7afl3	96	4	calcium	calcium	NN
cord-342936-43u7afl3	96	5	-	-	HYPH
cord-342936-43u7afl3	96	6	dependent	dependent	JJ
cord-342936-43u7afl3	96	7	multimeric	multimeric	JJ
cord-342936-43u7afl3	96	8	CBA	CBA	NNP
cord-342936-43u7afl3	96	9	that	that	WDT
cord-342936-43u7afl3	96	10	is	be	VBZ
cord-342936-43u7afl3	96	11	found	find	VBN
cord-342936-43u7afl3	96	12	in	in	IN
cord-342936-43u7afl3	96	13	serum	serum	NN
cord-342936-43u7afl3	96	14	13	13	CD
cord-342936-43u7afl3	96	15	,	,	,
cord-342936-43u7afl3	96	16	44	44	CD
cord-342936-43u7afl3	96	17	and	and	CC
cord-342936-43u7afl3	96	18	contains	contain	VBZ
cord-342936-43u7afl3	96	19	subunits	subunit	NNS
cord-342936-43u7afl3	96	20	of	of	IN
cord-342936-43u7afl3	96	21	approximately	approximately	RB
cord-342936-43u7afl3	96	22	31	31	CD
cord-342936-43u7afl3	96	23	kDa	kDa	NNS
cord-342936-43u7afl3	96	24	.	.	.
cord-342936-43u7afl3	97	1	Besides	besides	IN
cord-342936-43u7afl3	97	2	mannose	mannose	NN
cord-342936-43u7afl3	97	3	,	,	,
cord-342936-43u7afl3	97	4	it	-PRON-	PRP
cord-342936-43u7afl3	97	5	also	also	RB
cord-342936-43u7afl3	97	6	binds	bind	VBZ
cord-342936-43u7afl3	97	7	GlcNAc	GlcNAc	NNP
cord-342936-43u7afl3	97	8	and	and	CC
cord-342936-43u7afl3	97	9	fucose	fucose	NNP
cord-342936-43u7afl3	97	10	.	.	.
cord-342936-43u7afl3	98	1	MBL	MBL	NNP
cord-342936-43u7afl3	98	2	is	be	VBZ
cord-342936-43u7afl3	98	3	part	part	NN
cord-342936-43u7afl3	98	4	of	of	IN
cord-342936-43u7afl3	98	5	the	the	DT
cord-342936-43u7afl3	98	6	innate	innate	JJ
cord-342936-43u7afl3	98	7	immune	immune	JJ
cord-342936-43u7afl3	98	8	system	system	NN
cord-342936-43u7afl3	98	9	and	and	CC
cord-342936-43u7afl3	98	10	binds	bind	VBZ
cord-342936-43u7afl3	98	11	pathogens	pathogen	NNS
cord-342936-43u7afl3	98	12	as	as	IN
cord-342936-43u7afl3	98	13	the	the	DT
cord-342936-43u7afl3	98	14	initiating	initiate	VBG
cord-342936-43u7afl3	98	15	step	step	NN
cord-342936-43u7afl3	98	16	of	of	IN
cord-342936-43u7afl3	98	17	the	the	DT
cord-342936-43u7afl3	98	18	lectin	lectin	NN
cord-342936-43u7afl3	98	19	pathway	pathway	NN
cord-342936-43u7afl3	98	20	in	in	IN
cord-342936-43u7afl3	98	21	order	order	NN
cord-342936-43u7afl3	98	22	to	to	TO
cord-342936-43u7afl3	98	23	opsonize	opsonize	VB
cord-342936-43u7afl3	98	24	the	the	DT
cord-342936-43u7afl3	98	25	pathogen	pathogen	NN
cord-342936-43u7afl3	98	26	44	44	CD
cord-342936-43u7afl3	98	27	,	,	,
cord-342936-43u7afl3	98	28	45	45	CD
cord-342936-43u7afl3	98	29	.	.	.
cord-342936-43u7afl3	99	1	DC	DC	NNP
cord-342936-43u7afl3	99	2	-	-	HYPH
cord-342936-43u7afl3	99	3	SIGN	SIGN	NNP
cord-342936-43u7afl3	99	4	is	be	VBZ
cord-342936-43u7afl3	99	5	another	another	DT
cord-342936-43u7afl3	99	6	example	example	NN
cord-342936-43u7afl3	99	7	of	of	IN
cord-342936-43u7afl3	99	8	a	a	DT
cord-342936-43u7afl3	99	9	vertebrate	vertebrate	JJ
cord-342936-43u7afl3	99	10	mannose	mannose	NN
cord-342936-43u7afl3	99	11	-	-	HYPH
cord-342936-43u7afl3	99	12	specific	specific	JJ
cord-342936-43u7afl3	99	13	lectin	lectin	NN
cord-342936-43u7afl3	99	14	that	that	WDT
cord-342936-43u7afl3	99	15	is	be	VBZ
cord-342936-43u7afl3	99	16	predominantly	predominantly	RB
cord-342936-43u7afl3	99	17	present	present	JJ
cord-342936-43u7afl3	99	18	on	on	IN
cord-342936-43u7afl3	99	19	immature	immature	JJ
cord-342936-43u7afl3	99	20	DCs	DCs	NNP
cord-342936-43u7afl3	99	21	46	46	CD
cord-342936-43u7afl3	99	22	.	.	.
cord-342936-43u7afl3	100	1	It	-PRON-	PRP
cord-342936-43u7afl3	100	2	functions	function	VBZ
cord-342936-43u7afl3	100	3	in	in	IN
cord-342936-43u7afl3	100	4	DC	DC	NNP
cord-342936-43u7afl3	100	5	recognition	recognition	NN
cord-342936-43u7afl3	100	6	and	and	CC
cord-342936-43u7afl3	100	7	the	the	DT
cord-342936-43u7afl3	100	8	uptake	uptake	NN
cord-342936-43u7afl3	100	9	of	of	IN
cord-342936-43u7afl3	100	10	pathogens	pathogen	NNS
cord-342936-43u7afl3	100	11	(	(	-LRB-
cord-342936-43u7afl3	100	12	such	such	JJ
cord-342936-43u7afl3	100	13	as	as	IN
cord-342936-43u7afl3	100	14	HIV	HIV	NNP
cord-342936-43u7afl3	100	15	)	)	-RRB-
cord-342936-43u7afl3	100	16	,	,	,
cord-342936-43u7afl3	100	17	leading	lead	VBG
cord-342936-43u7afl3	100	18	to	to	IN
cord-342936-43u7afl3	100	19	antigen	antigen	NN
cord-342936-43u7afl3	100	20	presentation	presentation	NN
cord-342936-43u7afl3	100	21	to	to	IN
cord-342936-43u7afl3	100	22	T	t	NN
cord-342936-43u7afl3	100	23	cells	cell	NNS
cord-342936-43u7afl3	100	24	47	47	CD
cord-342936-43u7afl3	100	25	.	.	.
cord-342936-43u7afl3	101	1	Various	various	JJ
cord-342936-43u7afl3	101	2	other	other	JJ
cord-342936-43u7afl3	101	3	CBAs	cba	NNS
cord-342936-43u7afl3	101	4	,	,	,
cord-342936-43u7afl3	101	5	apart	apart	RB
cord-342936-43u7afl3	101	6	from	from	IN
cord-342936-43u7afl3	101	7	MBL	MBL	NNP
cord-342936-43u7afl3	101	8	or	or	CC
cord-342936-43u7afl3	101	9	DC	DC	NNP
cord-342936-43u7afl3	101	10	-	-	HYPH
cord-342936-43u7afl3	101	11	SIGN	SIGN	NNP
cord-342936-43u7afl3	101	12	,	,	,
cord-342936-43u7afl3	101	13	are	be	VBP
cord-342936-43u7afl3	101	14	also	also	RB
cord-342936-43u7afl3	101	15	part	part	NN
cord-342936-43u7afl3	101	16	of	of	IN
cord-342936-43u7afl3	101	17	the	the	DT
cord-342936-43u7afl3	101	18	innate	innate	JJ
cord-342936-43u7afl3	101	19	and/or	and/or	CC
cord-342936-43u7afl3	101	20	adaptive	adaptive	JJ
cord-342936-43u7afl3	101	21	immune	immune	JJ
cord-342936-43u7afl3	101	22	system	system	NN
cord-342936-43u7afl3	101	23	.	.	.
cord-342936-43u7afl3	102	1	Mammalian	mammalian	JJ
cord-342936-43u7afl3	102	2	defensins	defensin	NNS
cord-342936-43u7afl3	102	3	(	(	-LRB-
cord-342936-43u7afl3	102	4	α	α	NN
cord-342936-43u7afl3	102	5	,	,	,
cord-342936-43u7afl3	102	6	β	β	NN
cord-342936-43u7afl3	102	7	and	and	CC
cord-342936-43u7afl3	102	8	cyclic	cyclic	JJ
cord-342936-43u7afl3	102	9	Φ	Φ	NNP
cord-342936-43u7afl3	102	10	)	)	-RRB-
cord-342936-43u7afl3	102	11	,	,	,
cord-342936-43u7afl3	102	12	a	a	DT
cord-342936-43u7afl3	102	13	family	family	NN
cord-342936-43u7afl3	102	14	of	of	IN
cord-342936-43u7afl3	102	15	soluble	soluble	JJ
cord-342936-43u7afl3	102	16	glycan	glycan	NN
cord-342936-43u7afl3	102	17	-	-	HYPH
cord-342936-43u7afl3	102	18	binding	bind	VBG
cord-342936-43u7afl3	102	19	proteins	protein	NNS
cord-342936-43u7afl3	102	20	,	,	,
cord-342936-43u7afl3	102	21	are	be	VBP
cord-342936-43u7afl3	102	22	probably	probably	RB
cord-342936-43u7afl3	102	23	the	the	DT
cord-342936-43u7afl3	102	24	best	well	RBS
cord-342936-43u7afl3	102	25	-	-	HYPH
cord-342936-43u7afl3	102	26	studied	study	VBN
cord-342936-43u7afl3	102	27	lectins	lectin	NNS
cord-342936-43u7afl3	102	28	of	of	IN
cord-342936-43u7afl3	102	29	our	-PRON-	PRP$
cord-342936-43u7afl3	102	30	immune	immune	JJ
cord-342936-43u7afl3	102	31	system	system	NN
cord-342936-43u7afl3	102	32	15	15	CD
cord-342936-43u7afl3	102	33	.	.	.
cord-342936-43u7afl3	103	1	Galectins	Galectins	NNP
cord-342936-43u7afl3	103	2	also	also	RB
cord-342936-43u7afl3	103	3	have	have	VBP
cord-342936-43u7afl3	103	4	a	a	DT
cord-342936-43u7afl3	103	5	role	role	NN
cord-342936-43u7afl3	103	6	in	in	IN
cord-342936-43u7afl3	103	7	cell	cell	NN
cord-342936-43u7afl3	103	8	-	-	HYPH
cord-342936-43u7afl3	103	9	cell	cell	NN
cord-342936-43u7afl3	103	10	recognition	recognition	NN
cord-342936-43u7afl3	103	11	and	and	CC
cord-342936-43u7afl3	103	12	the	the	DT
cord-342936-43u7afl3	103	13	triggering	triggering	NN
cord-342936-43u7afl3	103	14	of	of	IN
cord-342936-43u7afl3	103	15	intracellular	intracellular	JJ
cord-342936-43u7afl3	103	16	signalling	signal	VBG
cord-342936-43u7afl3	103	17	cascades	cascade	NNS
cord-342936-43u7afl3	103	18	that	that	WDT
cord-342936-43u7afl3	103	19	lead	lead	VBP
cord-342936-43u7afl3	103	20	to	to	IN
cord-342936-43u7afl3	103	21	apoptosis	apoptosis	NN
cord-342936-43u7afl3	103	22	48	48	CD
cord-342936-43u7afl3	103	23	.	.	.
cord-342936-43u7afl3	104	1	Finally	finally	RB
cord-342936-43u7afl3	104	2	,	,	,
cord-342936-43u7afl3	104	3	the	the	DT
cord-342936-43u7afl3	104	4	monoclonal	monoclonal	JJ
cord-342936-43u7afl3	104	5	antibody	antibody	NN
cord-342936-43u7afl3	104	6	2G12	2g12	CD
cord-342936-43u7afl3	104	7	is	be	VBZ
cord-342936-43u7afl3	104	8	one	one	CD
cord-342936-43u7afl3	104	9	of	of	IN
cord-342936-43u7afl3	104	10	the	the	DT
cord-342936-43u7afl3	104	11	few	few	JJ
cord-342936-43u7afl3	104	12	broadly	broadly	RB
cord-342936-43u7afl3	104	13	neutralizing	neutralize	VBG
cord-342936-43u7afl3	104	14	anti	anti	JJ
cord-342936-43u7afl3	104	15	-	-	JJ
cord-342936-43u7afl3	104	16	HIV	hiv	JJ
cord-342936-43u7afl3	104	17	antibodies	antibody	NNS
cord-342936-43u7afl3	104	18	.	.	.
cord-342936-43u7afl3	105	1	It	-PRON-	PRP
cord-342936-43u7afl3	105	2	is	be	VBZ
cord-342936-43u7afl3	105	3	directed	direct	VBN
cord-342936-43u7afl3	105	4	against	against	IN
cord-342936-43u7afl3	105	5	an	an	DT
cord-342936-43u7afl3	105	6	epitope	epitope	NN
cord-342936-43u7afl3	105	7	on	on	IN
cord-342936-43u7afl3	105	8	the	the	DT
cord-342936-43u7afl3	105	9	HIV	HIV	NNP
cord-342936-43u7afl3	105	10	envelope	envelope	NN
cord-342936-43u7afl3	105	11	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	105	12	gp120	gp120	NNP
cord-342936-43u7afl3	105	13	,	,	,
cord-342936-43u7afl3	105	14	that	that	WDT
cord-342936-43u7afl3	105	15	lies	lie	VBZ
cord-342936-43u7afl3	105	16	around	around	IN
cord-342936-43u7afl3	105	17	the	the	DT
cord-342936-43u7afl3	105	18	C4-V4	C4-V4	NNP
cord-342936-43u7afl3	105	19	region	region	NN
cord-342936-43u7afl3	105	20	49	49	CD
cord-342936-43u7afl3	105	21	,	,	,
cord-342936-43u7afl3	105	22	50	50	CD
cord-342936-43u7afl3	105	23	.	.	.
cord-342936-43u7afl3	106	1	This	this	DT
cord-342936-43u7afl3	106	2	epitope	epitope	NN
cord-342936-43u7afl3	106	3	contains	contain	VBZ
cord-342936-43u7afl3	106	4	high	high	JJ
cord-342936-43u7afl3	106	5	-	-	HYPH
cord-342936-43u7afl3	106	6	mannose	mannose	NN
cord-342936-43u7afl3	106	7	-	-	HYPH
cord-342936-43u7afl3	106	8	type	type	NN
cord-342936-43u7afl3	106	9	glycans	glycan	NNS
cord-342936-43u7afl3	106	10	,	,	,
cord-342936-43u7afl3	106	11	which	which	WDT
cord-342936-43u7afl3	106	12	are	be	VBP
cord-342936-43u7afl3	106	13	present	present	JJ
cord-342936-43u7afl3	106	14	at	at	IN
cord-342936-43u7afl3	106	15	several	several	JJ
cord-342936-43u7afl3	106	16	highly	highly	RB
cord-342936-43u7afl3	106	17	conserved	conserved	JJ
cord-342936-43u7afl3	106	18	N	n	NN
cord-342936-43u7afl3	106	19	-	-	HYPH
cord-342936-43u7afl3	106	20	glycosylation	glycosylation	NN
cord-342936-43u7afl3	106	21	sites	site	NNS
cord-342936-43u7afl3	106	22	(	(	-LRB-
cord-342936-43u7afl3	106	23	specifically	specifically	RB
cord-342936-43u7afl3	106	24	N295	n295	CD
cord-342936-43u7afl3	106	25	,	,	,
cord-342936-43u7afl3	106	26	N332	n332	NN
cord-342936-43u7afl3	106	27	and	and	CC
cord-342936-43u7afl3	106	28	N392	N392	NNP
cord-342936-43u7afl3	106	29	in	in	IN
cord-342936-43u7afl3	106	30	gp120	gp120	CD
cord-342936-43u7afl3	106	31	)	)	-RRB-
cord-342936-43u7afl3	106	32	49	49	CD
cord-342936-43u7afl3	106	33	,	,	,
cord-342936-43u7afl3	106	34	51	51	CD
cord-342936-43u7afl3	106	35	.	.	.
cord-342936-43u7afl3	107	1	The	the	DT
cord-342936-43u7afl3	107	2	predominant	predominant	JJ
cord-342936-43u7afl3	107	3	interaction	interaction	NN
cord-342936-43u7afl3	107	4	sites	site	NNS
cord-342936-43u7afl3	107	5	of	of	IN
cord-342936-43u7afl3	107	6	2G12	2g12	CD
cord-342936-43u7afl3	107	7	with	with	IN
cord-342936-43u7afl3	107	8	gp120	gp120	NNP
cord-342936-43u7afl3	107	9	are	be	VBP
cord-342936-43u7afl3	107	10	probably	probably	RB
cord-342936-43u7afl3	107	11	the	the	DT
cord-342936-43u7afl3	107	12	terminal	terminal	JJ
cord-342936-43u7afl3	107	13	α(1,2)mannose	α(1,2)mannose	NNP
cord-342936-43u7afl3	107	14	oligomers	oligomer	NNS
cord-342936-43u7afl3	107	15	of	of	IN
cord-342936-43u7afl3	107	16	the	the	DT
cord-342936-43u7afl3	107	17	high	high	JJ
cord-342936-43u7afl3	107	18	-	-	HYPH
cord-342936-43u7afl3	107	19	mannose	mannose	NN
cord-342936-43u7afl3	107	20	glycans	glycan	NNS
cord-342936-43u7afl3	107	21	.	.	.
cord-342936-43u7afl3	108	1	It	-PRON-	PRP
cord-342936-43u7afl3	108	2	should	should	MD
cord-342936-43u7afl3	108	3	be	be	VB
cord-342936-43u7afl3	108	4	noted	note	VBN
cord-342936-43u7afl3	108	5	,	,	,
cord-342936-43u7afl3	108	6	however	however	RB
cord-342936-43u7afl3	108	7	,	,	,
cord-342936-43u7afl3	108	8	that	that	IN
cord-342936-43u7afl3	108	9	2G12	2g12	CD
cord-342936-43u7afl3	108	10	specifically	specifically	RB
cord-342936-43u7afl3	108	11	recognizes	recognize	VBZ
cord-342936-43u7afl3	108	12	HIV	HIV	NNP
cord-342936-43u7afl3	108	13	gp120	gp120	NNP
cord-342936-43u7afl3	108	14	glycans	glycan	NNS
cord-342936-43u7afl3	108	15	,	,	,
cord-342936-43u7afl3	108	16	but	but	CC
cord-342936-43u7afl3	108	17	does	do	VBZ
cord-342936-43u7afl3	108	18	not	not	RB
cord-342936-43u7afl3	108	19	specifically	specifically	RB
cord-342936-43u7afl3	108	20	interact	interact	VB
cord-342936-43u7afl3	108	21	with	with	IN
cord-342936-43u7afl3	108	22	peptide	peptide	NN
cord-342936-43u7afl3	108	23	moieties	moiety	NNS
cord-342936-43u7afl3	108	24	near	near	IN
cord-342936-43u7afl3	108	25	the	the	DT
cord-342936-43u7afl3	108	26	glycan	glycan	NN
cord-342936-43u7afl3	108	27	structures	structure	NNS
cord-342936-43u7afl3	108	28	on	on	IN
cord-342936-43u7afl3	108	29	gp120	gp120	NNP
cord-342936-43u7afl3	109	1	(	(	-LRB-
cord-342936-43u7afl3	109	2	REFS	ref	NNS
cord-342936-43u7afl3	109	3	49	49	CD
cord-342936-43u7afl3	109	4	-	-	SYM
cord-342936-43u7afl3	109	5	53	53	CD
cord-342936-43u7afl3	109	6	)	)	-RRB-
cord-342936-43u7afl3	109	7	.	.	.
cord-342936-43u7afl3	110	1	The	the	DT
cord-342936-43u7afl3	110	2	2G12	2g12	CD
cord-342936-43u7afl3	110	3	antibody	antibody	NN
cord-342936-43u7afl3	110	4	was	be	VBD
cord-342936-43u7afl3	110	5	found	find	VBN
cord-342936-43u7afl3	110	6	to	to	TO
cord-342936-43u7afl3	110	7	be	be	VB
cord-342936-43u7afl3	110	8	inhibitory	inhibitory	JJ
cord-342936-43u7afl3	110	9	to	to	IN
cord-342936-43u7afl3	110	10	HIV-1(III	hiv-1(iii	CD
cord-342936-43u7afl3	110	11	B	b	NN
cord-342936-43u7afl3	110	12	)	)	-RRB-
cord-342936-43u7afl3	110	13	in	in	IN
cord-342936-43u7afl3	110	14	different	different	JJ
cord-342936-43u7afl3	110	15	cell	cell	NN
cord-342936-43u7afl3	110	16	types	type	NNS
cord-342936-43u7afl3	110	17	at	at	IN
cord-342936-43u7afl3	110	18	an	an	DT
cord-342936-43u7afl3	110	19	EC	EC	NNP
cord-342936-43u7afl3	110	20	50	50	CD
cord-342936-43u7afl3	110	21	of	of	IN
cord-342936-43u7afl3	110	22	0.02	0.02	CD
cord-342936-43u7afl3	110	23	to	to	TO
cord-342936-43u7afl3	110	24	0.2	0.2	CD
cord-342936-43u7afl3	110	25	µg	µg	XX
cord-342936-43u7afl3	110	26	per	per	IN
cord-342936-43u7afl3	110	27	ml	ml	NN
cord-342936-43u7afl3	110	28	.	.	.
cord-342936-43u7afl3	111	1	However	however	RB
cord-342936-43u7afl3	111	2	,	,	,
cord-342936-43u7afl3	111	3	it	-PRON-	PRP
cord-342936-43u7afl3	111	4	should	should	MD
cord-342936-43u7afl3	111	5	be	be	VB
cord-342936-43u7afl3	111	6	noted	note	VBN
cord-342936-43u7afl3	111	7	that	that	IN
cord-342936-43u7afl3	111	8	2G12	2g12	CD
cord-342936-43u7afl3	111	9	activity	activity	NN
cord-342936-43u7afl3	111	10	can	can	MD
cord-342936-43u7afl3	111	11	vary	vary	VB
cord-342936-43u7afl3	111	12	depending	depend	VBG
cord-342936-43u7afl3	111	13	on	on	IN
cord-342936-43u7afl3	111	14	the	the	DT
cord-342936-43u7afl3	111	15	nature	nature	NN
cord-342936-43u7afl3	111	16	of	of	IN
cord-342936-43u7afl3	111	17	the	the	DT
cord-342936-43u7afl3	111	18	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	111	19	subtype	subtype	NN
cord-342936-43u7afl3	111	20	isolates	isolate	NNS
cord-342936-43u7afl3	111	21	that	that	WDT
cord-342936-43u7afl3	111	22	are	be	VBP
cord-342936-43u7afl3	111	23	evaluated	evaluate	VBN
cord-342936-43u7afl3	111	24	54	54	CD
cord-342936-43u7afl3	111	25	.	.	.
cord-342936-43u7afl3	112	1	In	in	IN
cord-342936-43u7afl3	112	2	the	the	DT
cord-342936-43u7afl3	112	3	course	course	NN
cord-342936-43u7afl3	112	4	of	of	IN
cord-342936-43u7afl3	112	5	screening	screening	NN
cord-342936-43u7afl3	112	6	for	for	IN
cord-342936-43u7afl3	112	7	new	new	JJ
cord-342936-43u7afl3	112	8	antibiotics	antibiotic	NNS
cord-342936-43u7afl3	112	9	that	that	WDT
cord-342936-43u7afl3	112	10	are	be	VBP
cord-342936-43u7afl3	112	11	active	active	JJ
cord-342936-43u7afl3	112	12	against	against	IN
cord-342936-43u7afl3	112	13	fungi	fungus	NNS
cord-342936-43u7afl3	112	14	,	,	,
cord-342936-43u7afl3	112	15	the	the	DT
cord-342936-43u7afl3	112	16	actinomycete	actinomycete	NN
cord-342936-43u7afl3	112	17	strain	strain	NN
cord-342936-43u7afl3	112	18	Actinomadura	Actinomadura	NNP
cord-342936-43u7afl3	112	19	hibisca	hibisca	NNP
cord-342936-43u7afl3	112	20	was	be	VBD
cord-342936-43u7afl3	112	21	found	find	VBN
cord-342936-43u7afl3	112	22	to	to	TO
cord-342936-43u7afl3	112	23	produce	produce	VB
cord-342936-43u7afl3	112	24	pradimicin	pradimicin	NNS
cord-342936-43u7afl3	112	25	A	a	DT
cord-342936-43u7afl3	112	26	(	(	-LRB-
cord-342936-43u7afl3	112	27	PRM	PRM	NNP
cord-342936-43u7afl3	112	28	-	-	HYPH
cord-342936-43u7afl3	112	29	A	a	NN
cord-342936-43u7afl3	112	30	)	)	-RRB-
cord-342936-43u7afl3	112	31	55	55	CD
cord-342936-43u7afl3	112	32	.	.	.
cord-342936-43u7afl3	113	1	This	this	DT
cord-342936-43u7afl3	113	2	antibiotic	antibiotic	NN
cord-342936-43u7afl3	113	3	has	have	VBZ
cord-342936-43u7afl3	113	4	a	a	DT
cord-342936-43u7afl3	113	5	unique	unique	JJ
cord-342936-43u7afl3	113	6	non	non	JJ
cord-342936-43u7afl3	113	7	-	-	JJ
cord-342936-43u7afl3	113	8	peptidic	peptidic	JJ
cord-342936-43u7afl3	113	9	structure	structure	NN
cord-342936-43u7afl3	113	10	that	that	WDT
cord-342936-43u7afl3	113	11	contains	contain	VBZ
cord-342936-43u7afl3	113	12	the	the	DT
cord-342936-43u7afl3	113	13	amino	amino	NN
cord-342936-43u7afl3	113	14	acid	acid	NN
cord-342936-43u7afl3	113	15	d	d	NNP
cord-342936-43u7afl3	113	16	-	-	:
cord-342936-43u7afl3	113	17	Ala	Ala	NNP
cord-342936-43u7afl3	113	18	and	and	CC
cord-342936-43u7afl3	113	19	the	the	DT
cord-342936-43u7afl3	113	20	carbohydrates	carbohydrate	NNS
cord-342936-43u7afl3	113	21	d	d	XX
cord-342936-43u7afl3	113	22	-	-	:
cord-342936-43u7afl3	113	23	xylose	xylose	NN
cord-342936-43u7afl3	113	24	and	and	CC
cord-342936-43u7afl3	113	25	4,6-dideoxy-4-methylamino	4,6-dideoxy-4-methylamino	CD
cord-342936-43u7afl3	113	26	-	-	HYPH
cord-342936-43u7afl3	113	27	d	d	NN
cord-342936-43u7afl3	113	28	-	-	HYPH
cord-342936-43u7afl3	113	29	galactose	galactose	NN
cord-342936-43u7afl3	113	30	attached	attach	VBN
cord-342936-43u7afl3	113	31	to	to	IN
cord-342936-43u7afl3	113	32	a	a	DT
cord-342936-43u7afl3	113	33	substituted	substitute	VBN
cord-342936-43u7afl3	113	34	5,6-dihydrobenzo[a]naphtacenequinone	5,6-dihydrobenzo[a]naphtacenequinone	CD
cord-342936-43u7afl3	113	35	(	(	-LRB-
cord-342936-43u7afl3	113	36	FIG	FIG	NNP
cord-342936-43u7afl3	113	37	.	.	.
cord-342936-43u7afl3	113	38	3a	3a	NNP
cord-342936-43u7afl3	113	39	)	)	-RRB-
cord-342936-43u7afl3	113	40	.	.	.
cord-342936-43u7afl3	114	1	PRM	PRM	NNP
cord-342936-43u7afl3	114	2	-	-	HYPH
cord-342936-43u7afl3	114	3	A	A	NNP
cord-342936-43u7afl3	114	4	binds	bind	VBZ
cord-342936-43u7afl3	114	5	to	to	IN
cord-342936-43u7afl3	114	6	terminal	terminal	NN
cord-342936-43u7afl3	114	7	d	d	NN
cord-342936-43u7afl3	114	8	-	-	HYPH
cord-342936-43u7afl3	114	9	mannose	mannose	JJ
cord-342936-43u7afl3	114	10	pyranoside	pyranoside	NN
cord-342936-43u7afl3	114	11	and	and	CC
cord-342936-43u7afl3	114	12	calcium	calcium	NN
cord-342936-43u7afl3	114	13	to	to	TO
cord-342936-43u7afl3	114	14	yield	yield	VB
cord-342936-43u7afl3	114	15	a	a	DT
cord-342936-43u7afl3	114	16	ternary	ternary	JJ
cord-342936-43u7afl3	114	17	complex	complex	NN
cord-342936-43u7afl3	114	18	that	that	WDT
cord-342936-43u7afl3	114	19	consists	consist	VBZ
cord-342936-43u7afl3	114	20	of	of	IN
cord-342936-43u7afl3	114	21	two	two	CD
cord-342936-43u7afl3	114	22	molecules	molecule	NNS
cord-342936-43u7afl3	114	23	of	of	IN
cord-342936-43u7afl3	114	24	PRM	PRM	NNP
cord-342936-43u7afl3	114	25	-	-	HYPH
cord-342936-43u7afl3	114	26	A	A	NNP
cord-342936-43u7afl3	114	27	,	,	,
cord-342936-43u7afl3	114	28	four	four	CD
cord-342936-43u7afl3	114	29	molecules	molecule	NNS
cord-342936-43u7afl3	114	30	of	of	IN
cord-342936-43u7afl3	114	31	mannose	mannose	NN
cord-342936-43u7afl3	114	32	and	and	CC
cord-342936-43u7afl3	114	33	one	one	CD
cord-342936-43u7afl3	114	34	calcium	calcium	NN
cord-342936-43u7afl3	114	35	atom	atom	NN
cord-342936-43u7afl3	114	36	56	56	CD
cord-342936-43u7afl3	114	37	.	.	.
cord-342936-43u7afl3	115	1	Benanomicin	Benanomicin	NNP
cord-342936-43u7afl3	115	2	A	A	NNP
cord-342936-43u7afl3	115	3	(	(	-LRB-
cord-342936-43u7afl3	115	4	BNM	BNM	NNP
cord-342936-43u7afl3	115	5	-	-	HYPH
cord-342936-43u7afl3	115	6	A	A	NNP
cord-342936-43u7afl3	115	7	)	)	-RRB-
cord-342936-43u7afl3	115	8	(	(	-LRB-
cord-342936-43u7afl3	115	9	FIG	FIG	NNP
cord-342936-43u7afl3	115	10	.	.	.
cord-342936-43u7afl3	115	11	3b	3b	NNP
cord-342936-43u7afl3	115	12	)	)	-RRB-
cord-342936-43u7afl3	115	13	,	,	,
cord-342936-43u7afl3	115	14	a	a	DT
cord-342936-43u7afl3	115	15	closely	closely	RB
cord-342936-43u7afl3	115	16	related	related	JJ
cord-342936-43u7afl3	115	17	antibiotic	antibiotic	NN
cord-342936-43u7afl3	115	18	with	with	IN
cord-342936-43u7afl3	115	19	mannose	mannose	JJ
cord-342936-43u7afl3	115	20	specificity	specificity	NN
cord-342936-43u7afl3	115	21	that	that	WDT
cord-342936-43u7afl3	115	22	is	be	VBZ
cord-342936-43u7afl3	115	23	similar	similar	JJ
cord-342936-43u7afl3	115	24	to	to	IN
cord-342936-43u7afl3	115	25	PRM	PRM	NNP
cord-342936-43u7afl3	115	26	-	-	HYPH
cord-342936-43u7afl3	115	27	A	A	NNP
cord-342936-43u7afl3	115	28	,	,	,
cord-342936-43u7afl3	115	29	has	have	VBZ
cord-342936-43u7afl3	115	30	also	also	RB
cord-342936-43u7afl3	115	31	been	be	VBN
cord-342936-43u7afl3	115	32	isolated	isolate	VBN
cord-342936-43u7afl3	115	33	from	from	IN
cord-342936-43u7afl3	115	34	the	the	DT
cord-342936-43u7afl3	115	35	actinomycete	actinomycete	JJ
cord-342936-43u7afl3	115	36	Actinomadura	Actinomadura	NNP
cord-342936-43u7afl3	115	37	spadix	spadix	NN
cord-342936-43u7afl3	115	38	and	and	CC
cord-342936-43u7afl3	115	39	studied	study	VBN
cord-342936-43u7afl3	115	40	for	for	IN
cord-342936-43u7afl3	115	41	antifungal	antifungal	JJ
cord-342936-43u7afl3	115	42	activity	activity	NN
cord-342936-43u7afl3	115	43	57	57	CD
cord-342936-43u7afl3	115	44	,	,	,
cord-342936-43u7afl3	115	45	58	58	CD
cord-342936-43u7afl3	115	46	.	.	.
cord-342936-43u7afl3	116	1	PRM	PRM	NNP
cord-342936-43u7afl3	116	2	-	-	HYPH
cord-342936-43u7afl3	116	3	A	A	NNP
cord-342936-43u7afl3	116	4	,	,	,
cord-342936-43u7afl3	116	5	BNM	BNM	NNP
cord-342936-43u7afl3	116	6	-	-	HYPH
cord-342936-43u7afl3	116	7	A	A	NNP
cord-342936-43u7afl3	116	8	and	and	CC
cord-342936-43u7afl3	116	9	semisynthetic	semisynthetic	JJ
cord-342936-43u7afl3	116	10	analogues	analogue	NNS
cord-342936-43u7afl3	116	11	of	of	IN
cord-342936-43u7afl3	116	12	these	these	DT
cord-342936-43u7afl3	116	13	compounds	compound	NNS
cord-342936-43u7afl3	116	14	are	be	VBP
cord-342936-43u7afl3	116	15	the	the	DT
cord-342936-43u7afl3	116	16	only	only	JJ
cord-342936-43u7afl3	116	17	antibiotics	antibiotic	NNS
cord-342936-43u7afl3	116	18	that	that	WDT
cord-342936-43u7afl3	116	19	are	be	VBP
cord-342936-43u7afl3	116	20	formally	formally	RB
cord-342936-43u7afl3	116	21	known	know	VBN
cord-342936-43u7afl3	116	22	to	to	TO
cord-342936-43u7afl3	116	23	have	have	VB
cord-342936-43u7afl3	116	24	well	well	RB
cord-342936-43u7afl3	116	25	-	-	HYPH
cord-342936-43u7afl3	116	26	defined	define	VBN
cord-342936-43u7afl3	116	27	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	116	28	-	-	HYPH
cord-342936-43u7afl3	116	29	binding	bind	VBG
cord-342936-43u7afl3	116	30	properties	property	NNS
cord-342936-43u7afl3	116	31	and	and	CC
cord-342936-43u7afl3	116	32	for	for	IN
cord-342936-43u7afl3	116	33	which	which	WDT
cord-342936-43u7afl3	116	34	the	the	DT
cord-342936-43u7afl3	116	35	antiviral	antiviral	JJ
cord-342936-43u7afl3	116	36	activity	activity	NN
cord-342936-43u7afl3	116	37	in	in	IN
cord-342936-43u7afl3	116	38	cell	cell	NN
cord-342936-43u7afl3	116	39	culture	culture	NN
cord-342936-43u7afl3	116	40	has	have	VBZ
cord-342936-43u7afl3	116	41	been	be	VBN
cord-342936-43u7afl3	116	42	reported	report	VBN
cord-342936-43u7afl3	116	43	(	(	-LRB-
cord-342936-43u7afl3	116	44	the	the	DT
cord-342936-43u7afl3	116	45	50	50	CD
cord-342936-43u7afl3	116	46	%	%	NN
cord-342936-43u7afl3	116	47	effective	effective	JJ
cord-342936-43u7afl3	116	48	concentration	concentration	NN
cord-342936-43u7afl3	116	49	against	against	IN
cord-342936-43u7afl3	116	50	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	116	51	ranks	rank	NNS
cord-342936-43u7afl3	116	52	in	in	IN
cord-342936-43u7afl3	116	53	the	the	DT
cord-342936-43u7afl3	116	54	lower	low	JJR
cord-342936-43u7afl3	116	55	micromolar	micromolar	JJ
cord-342936-43u7afl3	116	56	range	range	NN
cord-342936-43u7afl3	116	57	)	)	-RRB-
cord-342936-43u7afl3	116	58	[	[	-LRB-
cord-342936-43u7afl3	116	59	58	58	CD
cord-342936-43u7afl3	116	60	]	]	-RRB-
cord-342936-43u7afl3	116	61	[	[	-LRB-
cord-342936-43u7afl3	116	62	59	59	CD
cord-342936-43u7afl3	116	63	]	]	-RRB-
cord-342936-43u7afl3	116	64	[	[	-LRB-
cord-342936-43u7afl3	116	65	60	60	CD
cord-342936-43u7afl3	116	66	]	]	-RRB-
cord-342936-43u7afl3	116	67	.	.	.
cord-342936-43u7afl3	117	1	Several	several	JJ
cord-342936-43u7afl3	117	2	research	research	NN
cord-342936-43u7afl3	117	3	groups	group	NNS
cord-342936-43u7afl3	117	4	focus	focus	VBP
cord-342936-43u7afl3	117	5	on	on	IN
cord-342936-43u7afl3	117	6	the	the	DT
cord-342936-43u7afl3	117	7	synthesis	synthesis	NN
cord-342936-43u7afl3	117	8	and	and	CC
cord-342936-43u7afl3	117	9	characterization	characterization	NN
cord-342936-43u7afl3	117	10	of	of	IN
cord-342936-43u7afl3	117	11	synthetic	synthetic	JJ
cord-342936-43u7afl3	117	12	CBAs	cba	NNS
cord-342936-43u7afl3	117	13	that	that	WDT
cord-342936-43u7afl3	117	14	bind	bind	VBP
cord-342936-43u7afl3	117	15	specific	specific	JJ
cord-342936-43u7afl3	117	16	oligosaccharide	oligosaccharide	NN
cord-342936-43u7afl3	117	17	structures	structure	NNS
cord-342936-43u7afl3	117	18	.	.	.
cord-342936-43u7afl3	118	1	Binuclear	Binuclear	NNP
cord-342936-43u7afl3	118	2	copper	copper	NN
cord-342936-43u7afl3	118	3	(	(	-LRB-
cord-342936-43u7afl3	118	4	II	II	NNP
cord-342936-43u7afl3	118	5	)	)	-RRB-
cord-342936-43u7afl3	118	6	complexes	complex	NNS
cord-342936-43u7afl3	118	7	61	61	CD
cord-342936-43u7afl3	118	8	,	,	,
cord-342936-43u7afl3	118	9	acyclic	acyclic	JJ
cord-342936-43u7afl3	118	10	pyridine	pyridine	NN
cord-342936-43u7afl3	118	11	-	-	:
cord-342936-43u7afl3	118	12	and	and	CC
cord-342936-43u7afl3	118	13	pyrimidine	pyrimidine	NN
cord-342936-43u7afl3	118	14	-	-	HYPH
cord-342936-43u7afl3	118	15	based	base	VBN
cord-342936-43u7afl3	118	16	compounds	compound	NNS
cord-342936-43u7afl3	118	17	62	62	CD
cord-342936-43u7afl3	118	18	,	,	,
cord-342936-43u7afl3	118	19	and	and	CC
cord-342936-43u7afl3	119	1	tetrapyrrole	tetrapyrrole	NNP
cord-342936-43u7afl3	119	2	(	(	-LRB-
cord-342936-43u7afl3	119	3	porfyrin	porfyrin	NNP
cord-342936-43u7afl3	119	4	)	)	-RRB-
cord-342936-43u7afl3	119	5	derivatives	derivative	NNS
cord-342936-43u7afl3	119	6	have	have	VBP
cord-342936-43u7afl3	119	7	all	all	DT
cord-342936-43u7afl3	119	8	been	be	VBN
cord-342936-43u7afl3	119	9	reported	report	VBN
cord-342936-43u7afl3	119	10	to	to	TO
cord-342936-43u7afl3	119	11	have	have	VB
cord-342936-43u7afl3	119	12	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	119	13	-	-	HYPH
cord-342936-43u7afl3	119	14	binding	bind	VBG
cord-342936-43u7afl3	119	15	properties	property	NNS
cord-342936-43u7afl3	119	16	.	.	.
cord-342936-43u7afl3	120	1	These	these	DT
cord-342936-43u7afl3	120	2	compounds	compound	NNS
cord-342936-43u7afl3	120	3	may	may	MD
cord-342936-43u7afl3	120	4	have	have	VB
cord-342936-43u7afl3	120	5	potential	potential	JJ
cord-342936-43u7afl3	120	6	benefit	benefit	NN
cord-342936-43u7afl3	120	7	as	as	IN
cord-342936-43u7afl3	120	8	both	both	CC
cord-342936-43u7afl3	120	9	antiviral	antiviral	JJ
cord-342936-43u7afl3	120	10	and	and	CC
cord-342936-43u7afl3	120	11	diagnostic	diagnostic	JJ
cord-342936-43u7afl3	120	12	agents	agent	NNS
cord-342936-43u7afl3	120	13	.	.	.
cord-342936-43u7afl3	121	1	However	however	RB
cord-342936-43u7afl3	121	2	,	,	,
cord-342936-43u7afl3	121	3	for	for	IN
cord-342936-43u7afl3	121	4	these	these	DT
cord-342936-43u7afl3	121	5	small	small	JJ
cord-342936-43u7afl3	121	6	-	-	HYPH
cord-342936-43u7afl3	121	7	size	size	NN
cord-342936-43u7afl3	121	8	CBAs	cba	NNS
cord-342936-43u7afl3	121	9	,	,	,
cord-342936-43u7afl3	121	10	few	few	JJ
cord-342936-43u7afl3	121	11	,	,	,
cord-342936-43u7afl3	121	12	if	if	IN
cord-342936-43u7afl3	121	13	any	any	DT
cord-342936-43u7afl3	121	14	,	,	,
cord-342936-43u7afl3	121	15	antiviral	antiviral	JJ
cord-342936-43u7afl3	121	16	data	datum	NNS
cord-342936-43u7afl3	121	17	are	be	VBP
cord-342936-43u7afl3	121	18	available	available	JJ
cord-342936-43u7afl3	121	19	,	,	,
cord-342936-43u7afl3	121	20	and	and	CC
cord-342936-43u7afl3	121	21	their	-PRON-	PRP$
cord-342936-43u7afl3	121	22	potential	potential	NN
cord-342936-43u7afl3	121	23	for	for	IN
cord-342936-43u7afl3	121	24	cytotoxicity	cytotoxicity	NN
cord-342936-43u7afl3	121	25	has	have	VBZ
cord-342936-43u7afl3	121	26	not	not	RB
cord-342936-43u7afl3	121	27	been	be	VBN
cord-342936-43u7afl3	121	28	carefully	carefully	RB
cord-342936-43u7afl3	121	29	addressed	address	VBN
cord-342936-43u7afl3	121	30	so	so	RB
cord-342936-43u7afl3	121	31	far	far	RB
cord-342936-43u7afl3	121	32	.	.	.
cord-342936-43u7afl3	122	1	It	-PRON-	PRP
cord-342936-43u7afl3	122	2	would	would	MD
cord-342936-43u7afl3	122	3	be	be	VB
cord-342936-43u7afl3	122	4	interesting	interesting	JJ
cord-342936-43u7afl3	122	5	,	,	,
cord-342936-43u7afl3	122	6	therefore	therefore	RB
cord-342936-43u7afl3	122	7	,	,	,
cord-342936-43u7afl3	122	8	to	to	TO
cord-342936-43u7afl3	122	9	explore	explore	VB
cord-342936-43u7afl3	122	10	the	the	DT
cord-342936-43u7afl3	122	11	antiviral	antiviral	JJ
cord-342936-43u7afl3	122	12	properties	property	NNS
cord-342936-43u7afl3	122	13	of	of	IN
cord-342936-43u7afl3	122	14	such	such	JJ
cord-342936-43u7afl3	122	15	compounds	compound	NNS
cord-342936-43u7afl3	122	16	to	to	TO
cord-342936-43u7afl3	122	17	identify	identify	VB
cord-342936-43u7afl3	122	18	novel	novel	JJ
cord-342936-43u7afl3	122	19	synthetic	synthetic	JJ
cord-342936-43u7afl3	122	20	low	low	JJ
cord-342936-43u7afl3	122	21	-	-	HYPH
cord-342936-43u7afl3	122	22	molecular	molecular	JJ
cord-342936-43u7afl3	122	23	-	-	HYPH
cord-342936-43u7afl3	122	24	weight	weight	NN
cord-342936-43u7afl3	122	25	CBA	CBA	NNP
cord-342936-43u7afl3	122	26	lead	lead	VBP
cord-342936-43u7afl3	122	27	compounds	compound	NNS
cord-342936-43u7afl3	122	28	that	that	WDT
cord-342936-43u7afl3	122	29	have	have	VBP
cord-342936-43u7afl3	122	30	chemotherapeutic	chemotherapeutic	VBN
cord-342936-43u7afl3	122	31	potential	potential	NN
cord-342936-43u7afl3	122	32	.	.	.
cord-342936-43u7afl3	123	1	A	a	DT
cord-342936-43u7afl3	123	2	broad	broad	JJ
cord-342936-43u7afl3	123	3	range	range	NN
cord-342936-43u7afl3	123	4	of	of	IN
cord-342936-43u7afl3	123	5	proteins	protein	NNS
cord-342936-43u7afl3	123	6	bind	bind	VBP
cord-342936-43u7afl3	123	7	high	high	JJ
cord-342936-43u7afl3	123	8	-	-	HYPH
cord-342936-43u7afl3	123	9	mannose	mannose	NN
cord-342936-43u7afl3	123	10	-	-	HYPH
cord-342936-43u7afl3	123	11	type	type	NN
cord-342936-43u7afl3	123	12	glycans	glycan	NNS
cord-342936-43u7afl3	123	13	of	of	IN
cord-342936-43u7afl3	123	14	HIV	HIV	NNP
cord-342936-43u7afl3	123	15	gp120	gp120	NNP
cord-342936-43u7afl3	123	16	.	.	.
cord-342936-43u7afl3	124	1	Several	several	JJ
cord-342936-43u7afl3	124	2	binding	bind	VBG
cord-342936-43u7afl3	124	3	modes	mode	NNS
cord-342936-43u7afl3	124	4	can	can	MD
cord-342936-43u7afl3	124	5	be	be	VB
cord-342936-43u7afl3	124	6	distinguished	distinguish	VBN
cord-342936-43u7afl3	124	7	63	63	CD
cord-342936-43u7afl3	124	8	.	.	.
cord-342936-43u7afl3	125	1	One	one	CD
cord-342936-43u7afl3	125	2	group	group	NN
cord-342936-43u7afl3	125	3	of	of	IN
cord-342936-43u7afl3	125	4	lectins	lectin	NNS
cord-342936-43u7afl3	125	5	interact	interact	VBP
cord-342936-43u7afl3	125	6	as	as	IN
cord-342936-43u7afl3	125	7	C	c	NN
cord-342936-43u7afl3	125	8	-	-	HYPH
cord-342936-43u7afl3	125	9	type	type	NN
cord-342936-43u7afl3	125	10	lectins	lectin	NNS
cord-342936-43u7afl3	125	11	via	via	IN
cord-342936-43u7afl3	125	12	a	a	DT
cord-342936-43u7afl3	125	13	calcium	calcium	NN
cord-342936-43u7afl3	125	14	ion	ion	NN
cord-342936-43u7afl3	125	15	.	.	.
cord-342936-43u7afl3	126	1	Two	two	CD
cord-342936-43u7afl3	126	2	of	of	IN
cord-342936-43u7afl3	126	3	the	the	DT
cord-342936-43u7afl3	126	4	best	well	RBS
cord-342936-43u7afl3	126	5	-	-	HYPH
cord-342936-43u7afl3	126	6	known	know	VBN
cord-342936-43u7afl3	126	7	examples	example	NNS
cord-342936-43u7afl3	126	8	of	of	IN
cord-342936-43u7afl3	126	9	such	such	JJ
cord-342936-43u7afl3	126	10	calcium	calcium	NN
cord-342936-43u7afl3	126	11	-	-	HYPH
cord-342936-43u7afl3	126	12	dependent	dependent	JJ
cord-342936-43u7afl3	126	13	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	126	14	-	-	HYPH
cord-342936-43u7afl3	126	15	binding	bind	VBG
cord-342936-43u7afl3	126	16	lectins	lectin	NNS
cord-342936-43u7afl3	126	17	of	of	IN
cord-342936-43u7afl3	126	18	the	the	DT
cord-342936-43u7afl3	126	19	innate	innate	JJ
cord-342936-43u7afl3	126	20	immune	immune	JJ
cord-342936-43u7afl3	126	21	system	system	NN
cord-342936-43u7afl3	126	22	are	be	VBP
cord-342936-43u7afl3	126	23	DC	DC	NNP
cord-342936-43u7afl3	126	24	-	-	HYPH
cord-342936-43u7afl3	126	25	SIGN	sign	NN
cord-342936-43u7afl3	126	26	and	and	CC
cord-342936-43u7afl3	126	27	serum	serum	NN
cord-342936-43u7afl3	126	28	or	or	CC
cord-342936-43u7afl3	126	29	liver	liver	NN
cord-342936-43u7afl3	126	30	MBLs	mbl	NNS
cord-342936-43u7afl3	126	31	.	.	.
cord-342936-43u7afl3	127	1	Another	another	DT
cord-342936-43u7afl3	127	2	group	group	NN
cord-342936-43u7afl3	127	3	of	of	IN
cord-342936-43u7afl3	127	4	lectins	lectin	NNS
cord-342936-43u7afl3	127	5	interacts	interact	VBZ
cord-342936-43u7afl3	127	6	with	with	IN
cord-342936-43u7afl3	127	7	single	single	JJ
cord-342936-43u7afl3	127	8	-	-	HYPH
cord-342936-43u7afl3	127	9	terminal	terminal	NN
cord-342936-43u7afl3	127	10	carbohydrates	carbohydrate	NNS
cord-342936-43u7afl3	127	11	or	or	CC
cord-342936-43u7afl3	127	12	have	have	VBP
cord-342936-43u7afl3	127	13	more	more	RBR
cord-342936-43u7afl3	127	14	intimate	intimate	JJ
cord-342936-43u7afl3	127	15	interactions	interaction	NNS
cord-342936-43u7afl3	127	16	with	with	IN
cord-342936-43u7afl3	127	17	multiple	multiple	JJ
cord-342936-43u7afl3	127	18	sugar	sugar	NN
cord-342936-43u7afl3	127	19	rings	ring	NNS
cord-342936-43u7afl3	127	20	,	,	,
cord-342936-43u7afl3	127	21	without	without	IN
cord-342936-43u7afl3	127	22	the	the	DT
cord-342936-43u7afl3	127	23	need	need	NN
cord-342936-43u7afl3	127	24	of	of	IN
cord-342936-43u7afl3	127	25	a	a	DT
cord-342936-43u7afl3	127	26	metal	metal	NN
cord-342936-43u7afl3	127	27	ion	ion	NN
cord-342936-43u7afl3	127	28	.	.	.
cord-342936-43u7afl3	128	1	For	for	IN
cord-342936-43u7afl3	128	2	a	a	DT
cord-342936-43u7afl3	128	3	third	third	JJ
cord-342936-43u7afl3	128	4	group	group	NN
cord-342936-43u7afl3	128	5	of	of	IN
cord-342936-43u7afl3	128	6	lectins	lectin	NNS
cord-342936-43u7afl3	128	7	,	,	,
cord-342936-43u7afl3	128	8	the	the	DT
cord-342936-43u7afl3	128	9	interactions	interaction	NNS
cord-342936-43u7afl3	128	10	have	have	VBP
cord-342936-43u7afl3	128	11	not	not	RB
cord-342936-43u7afl3	128	12	yet	yet	RB
cord-342936-43u7afl3	128	13	been	be	VBN
cord-342936-43u7afl3	128	14	resolved	resolve	VBN
cord-342936-43u7afl3	128	15	.	.	.
cord-342936-43u7afl3	129	1	The	the	DT
cord-342936-43u7afl3	129	2	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	129	3	specificity	specificity	NN
cord-342936-43u7afl3	129	4	of	of	IN
cord-342936-43u7afl3	129	5	MBL	MBL	NNP
cord-342936-43u7afl3	129	6	is	be	VBZ
cord-342936-43u7afl3	129	7	broad	broad	JJ
cord-342936-43u7afl3	129	8	.	.	.
cord-342936-43u7afl3	130	1	The	the	DT
cord-342936-43u7afl3	130	2	MBLs	mbl	NNS
cord-342936-43u7afl3	130	3	recognize	recognize	VBP
cord-342936-43u7afl3	130	4	d	d	NN
cord-342936-43u7afl3	130	5	-	-	HYPH
cord-342936-43u7afl3	130	6	mannose	mannose	JJ
cord-342936-43u7afl3	130	7	,	,	,
cord-342936-43u7afl3	130	8	GlcNAc	GlcNAc	NNP
cord-342936-43u7afl3	130	9	and	and	CC
cord-342936-43u7afl3	130	10	l	l	NNP
cord-342936-43u7afl3	130	11	-	-	HYPH
cord-342936-43u7afl3	130	12	fucose	fucose	NNP
cord-342936-43u7afl3	130	13	.	.	.
cord-342936-43u7afl3	131	1	A	a	DT
cord-342936-43u7afl3	131	2	common	common	JJ
cord-342936-43u7afl3	131	3	motif	motif	NN
cord-342936-43u7afl3	131	4	among	among	IN
cord-342936-43u7afl3	131	5	these	these	DT
cord-342936-43u7afl3	131	6	sugars	sugar	NNS
cord-342936-43u7afl3	131	7	is	be	VBZ
cord-342936-43u7afl3	131	8	defined	define	VBN
cord-342936-43u7afl3	131	9	by	by	IN
cord-342936-43u7afl3	131	10	Figure	Figure	NNP
cord-342936-43u7afl3	131	11	3	3	CD
cord-342936-43u7afl3	131	12	|	|	NNP
cord-342936-43u7afl3	131	13	Low	low	JJ
cord-342936-43u7afl3	131	14	-	-	HYPH
cord-342936-43u7afl3	131	15	size	size	NN
cord-342936-43u7afl3	131	16	non	non	JJ
cord-342936-43u7afl3	131	17	-	-	JJ
cord-342936-43u7afl3	131	18	peptidic	peptidic	JJ
cord-342936-43u7afl3	131	19	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	131	20	-	-	HYPH
cord-342936-43u7afl3	131	21	binding	bind	VBG
cord-342936-43u7afl3	131	22	antigens	antigen	NNS
cord-342936-43u7afl3	131	23	(	(	-LRB-
cord-342936-43u7afl3	131	24	CBAs	CBAs	NNP
cord-342936-43u7afl3	131	25	)	)	-RRB-
cord-342936-43u7afl3	131	26	.	.	.
cord-342936-43u7afl3	132	1	Structural	structural	JJ
cord-342936-43u7afl3	132	2	formulae	formula	NNS
cord-342936-43u7afl3	132	3	of	of	IN
cord-342936-43u7afl3	132	4	the	the	DT
cord-342936-43u7afl3	132	5	calciumdependent	calciumdependent	NN
cord-342936-43u7afl3	132	6	mannose	mannose	NN
cord-342936-43u7afl3	132	7	-	-	HYPH
cord-342936-43u7afl3	132	8	binding	bind	VBG
cord-342936-43u7afl3	132	9	pradimicin	pradimicin	NNS
cord-342936-43u7afl3	132	10	A	A	NNP
cord-342936-43u7afl3	132	11	(	(	-LRB-
cord-342936-43u7afl3	132	12	a	a	NN
cord-342936-43u7afl3	132	13	)	)	-RRB-
cord-342936-43u7afl3	132	14	and	and	CC
cord-342936-43u7afl3	132	15	benanomicin	benanomicin	VBZ
cord-342936-43u7afl3	132	16	A	A	NNP
cord-342936-43u7afl3	132	17	(	(	-LRB-
cord-342936-43u7afl3	132	18	b	b	NN
cord-342936-43u7afl3	132	19	)	)	-RRB-
cord-342936-43u7afl3	132	20	antibiotic	antibiotic	JJ
cord-342936-43u7afl3	132	21	CBAs	cba	NNS
cord-342936-43u7afl3	132	22	that	that	WDT
cord-342936-43u7afl3	132	23	are	be	VBP
cord-342936-43u7afl3	132	24	produced	produce	VBN
cord-342936-43u7afl3	132	25	by	by	IN
cord-342936-43u7afl3	132	26	Actinomadura	Actinomadura	NNP
cord-342936-43u7afl3	132	27	hibiscus	hibiscus	NN
cord-342936-43u7afl3	132	28	and	and	CC
cord-342936-43u7afl3	132	29	Actinomadura	Actinomadura	NNP
cord-342936-43u7afl3	132	30	spadix	spadix	NN
cord-342936-43u7afl3	132	31	,	,	,
cord-342936-43u7afl3	132	32	respectively	respectively	RB
cord-342936-43u7afl3	132	33	.	.	.
cord-342936-43u7afl3	133	1	Red	Red	NNP
cord-342936-43u7afl3	133	2	represents	represent	VBZ
cord-342936-43u7afl3	133	3	the	the	DT
cord-342936-43u7afl3	133	4	d	d	JJ
cord-342936-43u7afl3	133	5	-	-	HYPH
cord-342936-43u7afl3	133	6	alanine	alanine	JJ
cord-342936-43u7afl3	133	7	moiety	moiety	NN
cord-342936-43u7afl3	133	8	;	;	:
cord-342936-43u7afl3	133	9	black	black	JJ
cord-342936-43u7afl3	133	10	represents	represent	VBZ
cord-342936-43u7afl3	133	11	the	the	DT
cord-342936-43u7afl3	133	12	dihydrobenzonaphtacenequinone	dihydrobenzonaphtacenequinone	NNP
cord-342936-43u7afl3	133	13	core	core	NN
cord-342936-43u7afl3	133	14	;	;	:
cord-342936-43u7afl3	133	15	green	green	JJ
cord-342936-43u7afl3	133	16	represents	represent	VBZ
cord-342936-43u7afl3	133	17	the	the	DT
cord-342936-43u7afl3	133	18	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	133	19	part	part	NN
cord-342936-43u7afl3	133	20	of	of	IN
cord-342936-43u7afl3	133	21	the	the	DT
cord-342936-43u7afl3	133	22	molecule	molecule	NN
cord-342936-43u7afl3	133	23	.	.	.
cord-342936-43u7afl3	134	1	Another	another	DT
cord-342936-43u7afl3	134	2	example	example	NN
cord-342936-43u7afl3	134	3	of	of	IN
cord-342936-43u7afl3	134	4	a	a	DT
cord-342936-43u7afl3	134	5	C	c	NN
cord-342936-43u7afl3	134	6	-	-	HYPH
cord-342936-43u7afl3	134	7	type	type	NN
cord-342936-43u7afl3	134	8	lectin	lectin	NN
cord-342936-43u7afl3	134	9	is	be	VBZ
cord-342936-43u7afl3	134	10	DC	DC	NNP
cord-342936-43u7afl3	134	11	-	-	HYPH
cord-342936-43u7afl3	134	12	SIGN	SIGN	NNP
cord-342936-43u7afl3	134	13	that	that	WDT
cord-342936-43u7afl3	134	14	has	have	VBZ
cord-342936-43u7afl3	134	15	been	be	VBN
cord-342936-43u7afl3	134	16	crystallized	crystallize	VBN
cord-342936-43u7afl3	134	17	in	in	IN
cord-342936-43u7afl3	134	18	complex	complex	NN
cord-342936-43u7afl3	134	19	with	with	IN
cord-342936-43u7afl3	134	20	Man	Man	NNP
cord-342936-43u7afl3	134	21	3	3	CD
cord-342936-43u7afl3	134	22	GlcNAc	glcnac	NN
cord-342936-43u7afl3	134	23	2	2	CD
cord-342936-43u7afl3	135	1	(	(	-LRB-
cord-342936-43u7afl3	135	2	REF	ref	NN
cord-342936-43u7afl3	135	3	.	.	.
cord-342936-43u7afl3	135	4	65	65	CD
cord-342936-43u7afl3	135	5	)	)	-RRB-
cord-342936-43u7afl3	136	1	(	(	-LRB-
cord-342936-43u7afl3	136	2	Protein	Protein	NNP
cord-342936-43u7afl3	136	3	Data	Data	NNP
cord-342936-43u7afl3	136	4	Bank	Bank	NNP
cord-342936-43u7afl3	136	5	(	(	-LRB-
cord-342936-43u7afl3	136	6	PDB	PDB	NNP
cord-342936-43u7afl3	136	7	)	)	-RRB-
cord-342936-43u7afl3	136	8	ID	ID	NNP
cord-342936-43u7afl3	136	9	lk9i	lk9i	NNP
cord-342936-43u7afl3	136	10	)	)	-RRB-
cord-342936-43u7afl3	137	1	(	(	-LRB-
cord-342936-43u7afl3	137	2	FIG	FIG	NNP
cord-342936-43u7afl3	137	3	.	.	.
cord-342936-43u7afl3	137	4	4b	4b	CD
cord-342936-43u7afl3	137	5	)	)	-RRB-
cord-342936-43u7afl3	137	6	.	.	.
cord-342936-43u7afl3	138	1	Interestingly	interestingly	RB
cord-342936-43u7afl3	138	2	,	,	,
cord-342936-43u7afl3	138	3	the	the	DT
cord-342936-43u7afl3	138	4	internal	internal	JJ
cord-342936-43u7afl3	138	5	α(1	α(1	NNP
cord-342936-43u7afl3	138	6	-	-	HYPH
cord-342936-43u7afl3	138	7	3)-mannose	3)-mannose	CD
cord-342936-43u7afl3	138	8	(	(	-LRB-
cord-342936-43u7afl3	138	9	Man)-linked	Man)-linked	NNP
cord-342936-43u7afl3	138	10	core	core	NN
cord-342936-43u7afl3	138	11	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	138	12	binds	bind	VBZ
cord-342936-43u7afl3	138	13	to	to	IN
cord-342936-43u7afl3	138	14	the	the	DT
cord-342936-43u7afl3	138	15	principal	principal	JJ
cord-342936-43u7afl3	138	16	calcium	calcium	NN
cord-342936-43u7afl3	138	17	site	site	NN
cord-342936-43u7afl3	138	18	.	.	.
cord-342936-43u7afl3	139	1	The	the	DT
cord-342936-43u7afl3	139	2	equatorial	equatorial	JJ
cord-342936-43u7afl3	139	3	C-3	C-3	NNP
cord-342936-43u7afl3	139	4	and	and	CC
cord-342936-43u7afl3	139	5	C-4	C-4	NNP
cord-342936-43u7afl3	139	6	hydroxyls	hydroxyls	NNP
cord-342936-43u7afl3	139	7	coordinate	coordinate	VBP
cord-342936-43u7afl3	139	8	the	the	DT
cord-342936-43u7afl3	139	9	calcium	calcium	NN
cord-342936-43u7afl3	139	10	ion	ion	NN
cord-342936-43u7afl3	139	11	and	and	CC
cord-342936-43u7afl3	139	12	form	form	VB
cord-342936-43u7afl3	139	13	hydrogen	hydrogen	NN
cord-342936-43u7afl3	139	14	bonds	bond	NNS
cord-342936-43u7afl3	139	15	with	with	IN
cord-342936-43u7afl3	139	16	the	the	DT
cord-342936-43u7afl3	139	17	amino	amino	NN
cord-342936-43u7afl3	139	18	acids	acid	NNS
cord-342936-43u7afl3	139	19	that	that	WDT
cord-342936-43u7afl3	139	20	coordinate	coordinate	VBP
cord-342936-43u7afl3	139	21	the	the	DT
cord-342936-43u7afl3	139	22	calcium	calcium	NN
cord-342936-43u7afl3	139	23	.	.	.
cord-342936-43u7afl3	140	1	UDA	UDA	NNP
cord-342936-43u7afl3	140	2	is	be	VBZ
cord-342936-43u7afl3	140	3	an	an	DT
cord-342936-43u7afl3	140	4	example	example	NN
cord-342936-43u7afl3	140	5	of	of	IN
cord-342936-43u7afl3	140	6	a	a	DT
cord-342936-43u7afl3	140	7	calcium	calcium	NN
cord-342936-43u7afl3	140	8	-	-	HYPH
cord-342936-43u7afl3	140	9	independent	independent	JJ
cord-342936-43u7afl3	140	10	CBA	CBA	NNP
cord-342936-43u7afl3	140	11	.	.	.
cord-342936-43u7afl3	141	1	A	a	DT
cord-342936-43u7afl3	141	2	bound	bound	JJ
cord-342936-43u7afl3	141	3	GlcNAc	glcnac	NN
cord-342936-43u7afl3	141	4	3	3	CD
cord-342936-43u7afl3	141	5	molecule	molecule	NN
cord-342936-43u7afl3	141	6	is	be	VBZ
cord-342936-43u7afl3	141	7	sandwiched	sandwich	VBN
cord-342936-43u7afl3	141	8	between	between	IN
cord-342936-43u7afl3	141	9	the	the	DT
cord-342936-43u7afl3	141	10	binding	bind	VBG
cord-342936-43u7afl3	141	11	sites	site	NNS
cord-342936-43u7afl3	141	12	of	of	IN
cord-342936-43u7afl3	141	13	the	the	DT
cord-342936-43u7afl3	141	14	high	high	JJ
cord-342936-43u7afl3	141	15	-	-	HYPH
cord-342936-43u7afl3	141	16	affinity	affinity	NN
cord-342936-43u7afl3	141	17	CBD	CBD	NNP
cord-342936-43u7afl3	141	18	of	of	IN
cord-342936-43u7afl3	141	19	a	a	DT
cord-342936-43u7afl3	141	20	first	first	JJ
cord-342936-43u7afl3	141	21	UDA	UDA	NNP
cord-342936-43u7afl3	141	22	molecule	molecule	NN
cord-342936-43u7afl3	141	23	and	and	CC
cord-342936-43u7afl3	141	24	the	the	DT
cord-342936-43u7afl3	141	25	low	low	JJ
cord-342936-43u7afl3	141	26	-	-	HYPH
cord-342936-43u7afl3	141	27	affinity	affinity	NN
cord-342936-43u7afl3	141	28	CBD	CBD	NNP
cord-342936-43u7afl3	141	29	of	of	IN
cord-342936-43u7afl3	141	30	a	a	DT
cord-342936-43u7afl3	141	31	second	second	JJ
cord-342936-43u7afl3	141	32	UDA	UDA	NNP
cord-342936-43u7afl3	141	33	molecule	molecule	NN
cord-342936-43u7afl3	141	34	.	.	.
cord-342936-43u7afl3	142	1	The	the	DT
cord-342936-43u7afl3	142	2	high	high	JJ
cord-342936-43u7afl3	142	3	-	-	HYPH
cord-342936-43u7afl3	142	4	affinity	affinity	NN
cord-342936-43u7afl3	142	5	CBD	CBD	NNP
cord-342936-43u7afl3	142	6	is	be	VBZ
cord-342936-43u7afl3	142	7	formed	form	VBN
cord-342936-43u7afl3	142	8	by	by	IN
cord-342936-43u7afl3	142	9	the	the	DT
cord-342936-43u7afl3	142	10	residues	residue	NNS
cord-342936-43u7afl3	142	11	Ser19	Ser19	NNP
cord-342936-43u7afl3	142	12	,	,	,
cord-342936-43u7afl3	142	13	Trp21	Trp21	NNP
cord-342936-43u7afl3	142	14	,	,	,
cord-342936-43u7afl3	142	15	Trp23	Trp23	NNP
cord-342936-43u7afl3	142	16	and	and	CC
cord-342936-43u7afl3	142	17	Tyr30	Tyr30	NNP
cord-342936-43u7afl3	142	18	.	.	.
cord-342936-43u7afl3	143	1	The	the	DT
cord-342936-43u7afl3	143	2	low	low	JJ
cord-342936-43u7afl3	143	3	-	-	HYPH
cord-342936-43u7afl3	143	4	affinity	affinity	NN
cord-342936-43u7afl3	143	5	Calcium	calcium	NN
cord-342936-43u7afl3	143	6	is	be	VBZ
cord-342936-43u7afl3	143	7	shown	show	VBN
cord-342936-43u7afl3	143	8	as	as	IN
cord-342936-43u7afl3	143	9	a	a	DT
cord-342936-43u7afl3	143	10	green	green	JJ
cord-342936-43u7afl3	143	11	sphere	sphere	NN
cord-342936-43u7afl3	143	12	,	,	,
cord-342936-43u7afl3	143	13	whereas	whereas	IN
cord-342936-43u7afl3	143	14	the	the	DT
cord-342936-43u7afl3	143	15	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	143	16	is	be	VBZ
cord-342936-43u7afl3	143	17	shown	show	VBN
cord-342936-43u7afl3	143	18	in	in	IN
cord-342936-43u7afl3	143	19	a	a	DT
cord-342936-43u7afl3	143	20	yellow	yellow	JJ
cord-342936-43u7afl3	143	21	stick	stick	NN
cord-342936-43u7afl3	143	22	representation	representation	NN
cord-342936-43u7afl3	143	23	.	.	.
cord-342936-43u7afl3	144	1	The	the	DT
cord-342936-43u7afl3	144	2	calcium	calcium	NN
cord-342936-43u7afl3	144	3	coordination	coordination	NN
cord-342936-43u7afl3	144	4	is	be	VBZ
cord-342936-43u7afl3	144	5	shown	show	VBN
cord-342936-43u7afl3	144	6	in	in	IN
cord-342936-43u7afl3	144	7	detail	detail	NN
cord-342936-43u7afl3	144	8	,	,	,
cord-342936-43u7afl3	144	9	with	with	IN
cord-342936-43u7afl3	144	10	the	the	DT
cord-342936-43u7afl3	144	11	hydrogen	hydrogen	NN
cord-342936-43u7afl3	144	12	bonds	bond	NNS
cord-342936-43u7afl3	144	13	to	to	IN
cord-342936-43u7afl3	144	14	important	important	JJ
cord-342936-43u7afl3	144	15	coordinating	coordinate	VBG
cord-342936-43u7afl3	144	16	residues	residue	NNS
cord-342936-43u7afl3	144	17	shown	show	VBN
cord-342936-43u7afl3	144	18	as	as	IN
cord-342936-43u7afl3	144	19	dotted	dotted	JJ
cord-342936-43u7afl3	144	20	spheres	sphere	NNS
cord-342936-43u7afl3	144	21	.	.	.
cord-342936-43u7afl3	145	1	The	the	DT
cord-342936-43u7afl3	145	2	gray	gray	JJ
cord-342936-43u7afl3	145	3	sphere	sphere	NN
cord-342936-43u7afl3	145	4	represents	represent	VBZ
cord-342936-43u7afl3	145	5	a	a	DT
cord-342936-43u7afl3	145	6	calcium	calcium	NN
cord-342936-43u7afl3	145	7	site	site	NN
cord-342936-43u7afl3	145	8	of	of	IN
cord-342936-43u7afl3	145	9	another	another	DT
cord-342936-43u7afl3	145	10	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	145	11	-	-	HYPH
cord-342936-43u7afl3	145	12	recognition	recognition	NN
cord-342936-43u7afl3	145	13	domain	domain	NN
cord-342936-43u7afl3	145	14	.	.	.
cord-342936-43u7afl3	146	1	c	c	NNP
cord-342936-43u7afl3	146	2	|	|	:
cord-342936-43u7afl3	146	3	Hydrogen	Hydrogen	NNP
cord-342936-43u7afl3	146	4	bonding	bonding	NN
cord-342936-43u7afl3	146	5	,	,	,
cord-342936-43u7afl3	146	6	van	van	NNP
cord-342936-43u7afl3	146	7	der	der	NNP
cord-342936-43u7afl3	146	8	Waals	Waals	NNP
cord-342936-43u7afl3	146	9	interactions	interaction	NNS
cord-342936-43u7afl3	146	10	and	and	CC
cord-342936-43u7afl3	146	11	aromatic	aromatic	JJ
cord-342936-43u7afl3	146	12	ring	ring	NN
cord-342936-43u7afl3	146	13	stacking	stacking	NN
cord-342936-43u7afl3	146	14	of	of	IN
cord-342936-43u7afl3	146	15	GlcNAc	GlcNAc	NNP
cord-342936-43u7afl3	146	16	3	3	CD
cord-342936-43u7afl3	146	17	,	,	,
cord-342936-43u7afl3	146	18	with	with	IN
cord-342936-43u7afl3	146	19	the	the	DT
cord-342936-43u7afl3	146	20	GlcNAc	glcnac	NN
cord-342936-43u7afl3	146	21	-	-	HYPH
cord-342936-43u7afl3	146	22	specific	specific	JJ
cord-342936-43u7afl3	146	23	lectin	lectin	NN
cord-342936-43u7afl3	146	24	from	from	IN
cord-342936-43u7afl3	146	25	Urtica	Urtica	NNP
cord-342936-43u7afl3	146	26	dioica	dioica	NN
cord-342936-43u7afl3	146	27	(	(	-LRB-
cord-342936-43u7afl3	146	28	UDA	UDA	NNP
cord-342936-43u7afl3	146	29	)	)	-RRB-
cord-342936-43u7afl3	146	30	37	37	CD
cord-342936-43u7afl3	147	1	(	(	-LRB-
cord-342936-43u7afl3	147	2	PDB	PDB	NNP
cord-342936-43u7afl3	147	3	ID	ID	NNP
cord-342936-43u7afl3	147	4	1ehh	1ehh	CD
cord-342936-43u7afl3	147	5	)	)	-RRB-
cord-342936-43u7afl3	147	6	.	.	.
cord-342936-43u7afl3	148	1	Two	two	CD
cord-342936-43u7afl3	148	2	isolectin	isolectin	NN
cord-342936-43u7afl3	148	3	VI	vi	NN
cord-342936-43u7afl3	148	4	molecules	molecule	NNS
cord-342936-43u7afl3	148	5	are	be	VBP
cord-342936-43u7afl3	148	6	shown	show	VBN
cord-342936-43u7afl3	148	7	in	in	IN
cord-342936-43u7afl3	148	8	blue	blue	JJ
cord-342936-43u7afl3	148	9	and	and	CC
cord-342936-43u7afl3	148	10	green	green	JJ
cord-342936-43u7afl3	148	11	.	.	.
cord-342936-43u7afl3	149	1	Dotted	dotted	JJ
cord-342936-43u7afl3	149	2	lines	line	NNS
cord-342936-43u7afl3	149	3	are	be	VBP
cord-342936-43u7afl3	149	4	hydrogen	hydrogen	NN
cord-342936-43u7afl3	149	5	-	-	HYPH
cord-342936-43u7afl3	149	6	bonding	bond	VBG
cord-342936-43u7afl3	149	7	contacts	contact	NNS
cord-342936-43u7afl3	149	8	between	between	IN
cord-342936-43u7afl3	149	9	UDA	UDA	NNP
cord-342936-43u7afl3	149	10	and	and	CC
cord-342936-43u7afl3	149	11	GlcNAc	GlcNAc	NNP
cord-342936-43u7afl3	149	12	3	3	CD
cord-342936-43u7afl3	149	13	.	.	.
cord-342936-43u7afl3	150	1	Sugar	sugar	NN
cord-342936-43u7afl3	150	2	residues	residue	NNS
cord-342936-43u7afl3	150	3	are	be	VBP
cord-342936-43u7afl3	150	4	labelled	label	VBN
cord-342936-43u7afl3	150	5	with	with	IN
cord-342936-43u7afl3	150	6	A	a	NN
cord-342936-43u7afl3	150	7	,	,	,
cord-342936-43u7afl3	150	8	B	b	NN
cord-342936-43u7afl3	150	9	,	,	,
cord-342936-43u7afl3	150	10	and	and	CC
cord-342936-43u7afl3	150	11	C	c	NN
cord-342936-43u7afl3	150	12	from	from	IN
cord-342936-43u7afl3	150	13	the	the	DT
cord-342936-43u7afl3	150	14	non	non	JJ
cord-342936-43u7afl3	150	15	-	-	JJ
cord-342936-43u7afl3	150	16	reducing	reducing	JJ
cord-342936-43u7afl3	150	17	end	end	NN
cord-342936-43u7afl3	150	18	.	.	.
cord-342936-43u7afl3	151	1	d	d	NNP
cord-342936-43u7afl3	151	2	|	|	NNP
cord-342936-43u7afl3	151	3	Hydrogen	Hydrogen	NNP
cord-342936-43u7afl3	151	4	-	-	HYPH
cord-342936-43u7afl3	151	5	bonding	bonding	NN
cord-342936-43u7afl3	151	6	pattern	pattern	NN
cord-342936-43u7afl3	151	7	and	and	CC
cord-342936-43u7afl3	151	8	van	van	NNP
cord-342936-43u7afl3	151	9	der	der	NNP
cord-342936-43u7afl3	151	10	Waals	Waals	NNP
cord-342936-43u7afl3	151	11	contacts	contact	NNS
cord-342936-43u7afl3	151	12	of	of	IN
cord-342936-43u7afl3	151	13	the	the	DT
cord-342936-43u7afl3	151	14	Narcissus	Narcissus	NNP
cord-342936-43u7afl3	151	15	psuedonarcissus	psuedonarcissus	NN
cord-342936-43u7afl3	151	16	lectin	lectin	NN
cord-342936-43u7afl3	151	17	7	7	CD
cord-342936-43u7afl3	151	18	(	(	-LRB-
cord-342936-43u7afl3	151	19	NPL7	NPL7	NNP
cord-342936-43u7afl3	151	20	)	)	-RRB-
cord-342936-43u7afl3	151	21	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	151	22	-	-	HYPH
cord-342936-43u7afl3	151	23	binding	bind	VBG
cord-342936-43u7afl3	151	24	domain	domain	NN
cord-342936-43u7afl3	151	25	complexed	complexe	VBN
cord-342936-43u7afl3	151	26	to	to	IN
cord-342936-43u7afl3	151	27	Manα	Manα	NNP
cord-342936-43u7afl3	151	28	CBD	CBD	NNP
cord-342936-43u7afl3	151	29	is	be	VBZ
cord-342936-43u7afl3	151	30	formed	form	VBN
cord-342936-43u7afl3	151	31	by	by	IN
cord-342936-43u7afl3	151	32	the	the	DT
cord-342936-43u7afl3	151	33	residues	residue	NNS
cord-342936-43u7afl3	151	34	Ser65	Ser65	NNP
cord-342936-43u7afl3	151	35	,	,	,
cord-342936-43u7afl3	151	36	His67	His67	NNP
cord-342936-43u7afl3	151	37	,	,	,
cord-342936-43u7afl3	151	38	Trp69	Trp69	NNP
cord-342936-43u7afl3	151	39	and	and	CC
cord-342936-43u7afl3	151	40	Tyr76	Tyr76	NNP
cord-342936-43u7afl3	151	41	.	.	.
cord-342936-43u7afl3	152	1	Of	of	IN
cord-342936-43u7afl3	152	2	most	most	JJS
cord-342936-43u7afl3	152	3	importance	importance	NN
cord-342936-43u7afl3	152	4	for	for	IN
cord-342936-43u7afl3	152	5	sugar	sugar	NN
cord-342936-43u7afl3	152	6	recognition	recognition	NN
cord-342936-43u7afl3	152	7	are	be	VBP
cord-342936-43u7afl3	152	8	the	the	DT
cord-342936-43u7afl3	152	9	multiple	multiple	JJ
cord-342936-43u7afl3	152	10	hydrogen	hydrogen	NN
cord-342936-43u7afl3	152	11	bonds	bond	NNS
cord-342936-43u7afl3	152	12	,	,	,
cord-342936-43u7afl3	152	13	van	van	NNP
cord-342936-43u7afl3	152	14	der	der	NNP
cord-342936-43u7afl3	152	15	Waals	Waals	NNP
cord-342936-43u7afl3	152	16	interactions	interaction	NNS
cord-342936-43u7afl3	152	17	and	and	CC
cord-342936-43u7afl3	152	18	aromatic	aromatic	JJ
cord-342936-43u7afl3	152	19	-	-	HYPH
cord-342936-43u7afl3	152	20	ring	ring	NN
cord-342936-43u7afl3	152	21	stacking	stacking	NN
cord-342936-43u7afl3	152	22	of	of	IN
cord-342936-43u7afl3	152	23	GlcNAc	GlcNAc	NNP
cord-342936-43u7afl3	152	24	3	3	CD
cord-342936-43u7afl3	152	25	with	with	IN
cord-342936-43u7afl3	152	26	the	the	DT
cord-342936-43u7afl3	152	27	two	two	CD
cord-342936-43u7afl3	152	28	UDA	UDA	NNP
cord-342936-43u7afl3	152	29	molecules	molecule	NNS
cord-342936-43u7afl3	152	30	37	37	CD
cord-342936-43u7afl3	153	1	(	(	-LRB-
cord-342936-43u7afl3	153	2	PDB	PDB	NNP
cord-342936-43u7afl3	153	3	ID	ID	NNP
cord-342936-43u7afl3	153	4	1ehh	1ehh	CD
cord-342936-43u7afl3	153	5	)	)	-RRB-
cord-342936-43u7afl3	153	6	(	(	-LRB-
cord-342936-43u7afl3	153	7	FIG	FIG	NNP
cord-342936-43u7afl3	153	8	.	.	.
cord-342936-43u7afl3	153	9	4c	4c	CD
cord-342936-43u7afl3	153	10	)	)	-RRB-
cord-342936-43u7afl3	153	11	.	.	.
cord-342936-43u7afl3	154	1	Indeed	indeed	RB
cord-342936-43u7afl3	154	2	,	,	,
cord-342936-43u7afl3	154	3	at	at	RB
cord-342936-43u7afl3	154	4	least	least	RBS
cord-342936-43u7afl3	154	5	five	five	CD
cord-342936-43u7afl3	154	6	hydrogen	hydrogen	NN
cord-342936-43u7afl3	154	7	bonds	bond	NNS
cord-342936-43u7afl3	154	8	are	be	VBP
cord-342936-43u7afl3	154	9	formed	form	VBN
cord-342936-43u7afl3	154	10	in	in	IN
cord-342936-43u7afl3	154	11	the	the	DT
cord-342936-43u7afl3	154	12	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	154	13	-	-	HYPH
cord-342936-43u7afl3	154	14	lectin	lectin	NN
cord-342936-43u7afl3	154	15	complex	complex	NN
cord-342936-43u7afl3	154	16	,	,	,
cord-342936-43u7afl3	154	17	as	as	RB
cord-342936-43u7afl3	154	18	well	well	RB
cord-342936-43u7afl3	154	19	as	as	IN
cord-342936-43u7afl3	154	20	several	several	JJ
cord-342936-43u7afl3	154	21	ring	ring	NN
cord-342936-43u7afl3	154	22	stackings	stacking	NNS
cord-342936-43u7afl3	154	23	between	between	IN
cord-342936-43u7afl3	154	24	the	the	DT
cord-342936-43u7afl3	154	25	individual	individual	JJ
cord-342936-43u7afl3	154	26	GlcNAc	GlcNAc	NNP
cord-342936-43u7afl3	154	27	entities	entity	NNS
cord-342936-43u7afl3	154	28	and	and	CC
cord-342936-43u7afl3	154	29	the	the	DT
cord-342936-43u7afl3	154	30	Trp21	Trp21	NNP
cord-342936-43u7afl3	154	31	,	,	,
cord-342936-43u7afl3	154	32	Trp23	Trp23	NNP
cord-342936-43u7afl3	154	33	,	,	,
cord-342936-43u7afl3	154	34	Trp69	Trp69	NNP
cord-342936-43u7afl3	154	35	and	and	CC
cord-342936-43u7afl3	154	36	His67	His67	NNP
cord-342936-43u7afl3	154	37	residues	residue	NNS
cord-342936-43u7afl3	154	38	of	of	IN
cord-342936-43u7afl3	154	39	the	the	DT
cord-342936-43u7afl3	154	40	UDA	UDA	NNP
cord-342936-43u7afl3	154	41	molecules	molecule	NNS
cord-342936-43u7afl3	154	42	.	.	.
cord-342936-43u7afl3	155	1	The	the	DT
cord-342936-43u7afl3	155	2	molecular	molecular	JJ
cord-342936-43u7afl3	155	3	interaction	interaction	NN
cord-342936-43u7afl3	155	4	of	of	IN
cord-342936-43u7afl3	155	5	the	the	DT
cord-342936-43u7afl3	155	6	Narcissus	Narcissus	NNP
cord-342936-43u7afl3	155	7	pseudonarcissus	pseudonarcissus	NN
cord-342936-43u7afl3	155	8	lectin	lectin	NN
cord-342936-43u7afl3	155	9	with	with	IN
cord-342936-43u7afl3	155	10	Manα1	Manα1	NNP
cord-342936-43u7afl3	155	11	-	-	HYPH
cord-342936-43u7afl3	155	12	3Man	3man	JJ
cord-342936-43u7afl3	155	13	has	have	VBZ
cord-342936-43u7afl3	155	14	also	also	RB
cord-342936-43u7afl3	155	15	been	be	VBN
cord-342936-43u7afl3	155	16	revealed	reveal	VBN
cord-342936-43u7afl3	155	17	66	66	CD
cord-342936-43u7afl3	156	1	(	(	-LRB-
cord-342936-43u7afl3	156	2	PDB	PDB	NNP
cord-342936-43u7afl3	156	3	ID	ID	NNP
cord-342936-43u7afl3	156	4	1npl	1npl	CD
cord-342936-43u7afl3	156	5	)	)	-RRB-
cord-342936-43u7afl3	157	1	(	(	-LRB-
cord-342936-43u7afl3	157	2	FIG	FIG	NNP
cord-342936-43u7afl3	157	3	.	.	.
cord-342936-43u7afl3	157	4	4d	4d	CD
cord-342936-43u7afl3	157	5	)	)	-RRB-
cord-342936-43u7afl3	157	6	.	.	.
cord-342936-43u7afl3	158	1	The	the	DT
cord-342936-43u7afl3	158	2	Narcissus	Narcissus	NNP
cord-342936-43u7afl3	158	3	psuedonarcissus	psuedonarcissus	NN
cord-342936-43u7afl3	158	4	lectin	lectin	NN
cord-342936-43u7afl3	158	5	7	7	CD
cord-342936-43u7afl3	159	1	(	(	-LRB-
cord-342936-43u7afl3	159	2	NPL7	NPL7	NNP
cord-342936-43u7afl3	159	3	)	)	-RRB-
cord-342936-43u7afl3	159	4	isolectin	isolectin	NNP
cord-342936-43u7afl3	159	5	contains	contain	VBZ
cord-342936-43u7afl3	159	6	three	three	CD
cord-342936-43u7afl3	159	7	CBDs	cbd	NNS
cord-342936-43u7afl3	159	8	in	in	IN
cord-342936-43u7afl3	159	9	one	one	CD
cord-342936-43u7afl3	159	10	monomer	monomer	NN
cord-342936-43u7afl3	159	11	.	.	.
cord-342936-43u7afl3	160	1	Each	each	DT
cord-342936-43u7afl3	160	2	CBD	CBD	NNP
cord-342936-43u7afl3	160	3	in	in	IN
cord-342936-43u7afl3	160	4	NPL7	NPL7	NNP
cord-342936-43u7afl3	160	5	seems	seem	VBZ
cord-342936-43u7afl3	160	6	to	to	TO
cord-342936-43u7afl3	160	7	have	have	VB
cord-342936-43u7afl3	160	8	equal	equal	JJ
cord-342936-43u7afl3	160	9	affinity	affinity	NN
cord-342936-43u7afl3	160	10	for	for	IN
cord-342936-43u7afl3	160	11	the	the	DT
cord-342936-43u7afl3	160	12	particular	particular	JJ
cord-342936-43u7afl3	160	13	carbohydrates	carbohydrate	NNS
cord-342936-43u7afl3	160	14	and	and	CC
cord-342936-43u7afl3	160	15	are	be	VBP
cord-342936-43u7afl3	160	16	equally	equally	RB
cord-342936-43u7afl3	160	17	occupied	occupied	JJ
cord-342936-43u7afl3	160	18	.	.	.
cord-342936-43u7afl3	161	1	In	in	IN
cord-342936-43u7afl3	161	2	addition	addition	NN
cord-342936-43u7afl3	161	3	to	to	IN
cord-342936-43u7afl3	161	4	the	the	DT
cord-342936-43u7afl3	161	5	three	three	CD
cord-342936-43u7afl3	161	6	conserved	conserved	JJ
cord-342936-43u7afl3	161	7	CBDs	cbd	NNS
cord-342936-43u7afl3	161	8	,	,	,
cord-342936-43u7afl3	161	9	a	a	DT
cord-342936-43u7afl3	161	10	unique	unique	JJ
cord-342936-43u7afl3	161	11	fourth	fourth	JJ
cord-342936-43u7afl3	161	12	(	(	-LRB-
cord-342936-43u7afl3	161	13	low	low	JJ
cord-342936-43u7afl3	161	14	-	-	HYPH
cord-342936-43u7afl3	161	15	affinity	affinity	NN
cord-342936-43u7afl3	161	16	)	)	-RRB-
cord-342936-43u7afl3	161	17	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	161	18	-	-	HYPH
cord-342936-43u7afl3	161	19	binding	bind	VBG
cord-342936-43u7afl3	161	20	site	site	NN
cord-342936-43u7afl3	161	21	has	have	VBZ
cord-342936-43u7afl3	161	22	been	be	VBN
cord-342936-43u7afl3	161	23	observed	observe	VBN
cord-342936-43u7afl3	161	24	near	near	IN
cord-342936-43u7afl3	161	25	the	the	DT
cord-342936-43u7afl3	161	26	tryptophan	tryptophan	NN
cord-342936-43u7afl3	161	27	cluster	cluster	NN
cord-342936-43u7afl3	161	28	.	.	.
cord-342936-43u7afl3	162	1	Three	three	CD
cord-342936-43u7afl3	162	2	residues	residue	NNS
cord-342936-43u7afl3	162	3	(	(	-LRB-
cord-342936-43u7afl3	162	4	Asn30	Asn30	NNP
cord-342936-43u7afl3	162	5	,	,	,
cord-342936-43u7afl3	162	6	Asp28	Asp28	NNP
cord-342936-43u7afl3	162	7	and	and	CC
cord-342936-43u7afl3	162	8	Gln26	Gln26	NNP
cord-342936-43u7afl3	162	9	)	)	-RRB-
cord-342936-43u7afl3	162	10	create	create	VB
cord-342936-43u7afl3	162	11	a	a	DT
cord-342936-43u7afl3	162	12	polar	polar	JJ
cord-342936-43u7afl3	162	13	patch	patch	NN
cord-342936-43u7afl3	162	14	in	in	IN
cord-342936-43u7afl3	162	15	the	the	DT
cord-342936-43u7afl3	162	16	CBD	CBD	NNP
cord-342936-43u7afl3	162	17	pocket	pocket	NN
cord-342936-43u7afl3	162	18	that	that	WDT
cord-342936-43u7afl3	162	19	restricts	restrict	VBZ
cord-342936-43u7afl3	162	20	the	the	DT
cord-342936-43u7afl3	162	21	carbohydate	carbohydate	NN
cord-342936-43u7afl3	162	22	ligand	ligand	NN
cord-342936-43u7afl3	162	23	to	to	IN
cord-342936-43u7afl3	162	24	an	an	DT
cord-342936-43u7afl3	162	25	axial	axial	JJ
cord-342936-43u7afl3	162	26	hydroxyl	hydroxyl	NN
cord-342936-43u7afl3	162	27	group	group	NN
cord-342936-43u7afl3	162	28	at	at	IN
cord-342936-43u7afl3	162	29	C-2	C-2	NNP
cord-342936-43u7afl3	162	30	.	.	.
cord-342936-43u7afl3	163	1	The	the	DT
cord-342936-43u7afl3	163	2	multi	multi	JJ
cord-342936-43u7afl3	163	3	-	-	JJ
cord-342936-43u7afl3	163	4	alignment	alignment	NN
cord-342936-43u7afl3	163	5	of	of	IN
cord-342936-43u7afl3	163	6	various	various	JJ
cord-342936-43u7afl3	163	7	monocot	monocot	NN
cord-342936-43u7afl3	163	8	mannosebinding	mannosebinde	VBG
cord-342936-43u7afl3	163	9	lectins	lectin	NNS
cord-342936-43u7afl3	163	10	revealed	reveal	VBD
cord-342936-43u7afl3	163	11	a	a	DT
cord-342936-43u7afl3	163	12	striking	striking	JJ
cord-342936-43u7afl3	163	13	sequence	sequence	NN
cord-342936-43u7afl3	163	14	identity	identity	NN
cord-342936-43u7afl3	163	15	among	among	IN
cord-342936-43u7afl3	163	16	Narcissus	Narcissus	NNP
cord-342936-43u7afl3	163	17	pneudonarcissus	pneudonarcissus	NNP
cord-342936-43u7afl3	163	18	agglutinin	agglutinin	NNP
cord-342936-43u7afl3	163	19	(	(	-LRB-
cord-342936-43u7afl3	163	20	NPA	NPA	NNP
cord-342936-43u7afl3	163	21	)	)	-RRB-
cord-342936-43u7afl3	163	22	,	,	.
cord-342936-43u7afl3	164	1	Narcissus	Narcissus	NNP
cord-342936-43u7afl3	164	2	hybrid	hybrid	NN
cord-342936-43u7afl3	164	3	cultivar	cultivar	NN
cord-342936-43u7afl3	164	4	agglutinin	agglutinin	NNS
cord-342936-43u7afl3	164	5	(	(	-LRB-
cord-342936-43u7afl3	164	6	NHA	NHA	NNP
cord-342936-43u7afl3	164	7	)	)	-RRB-
cord-342936-43u7afl3	164	8	,	,	,
cord-342936-43u7afl3	164	9	Galanthus	Galanthus	NNP
cord-342936-43u7afl3	164	10	nivalis	nivalis	NNP
cord-342936-43u7afl3	164	11	agglutinin	agglutinin	NNP
cord-342936-43u7afl3	164	12	(	(	-LRB-
cord-342936-43u7afl3	164	13	GNA	GNA	NNP
cord-342936-43u7afl3	164	14	)	)	-RRB-
cord-342936-43u7afl3	164	15	,	,	,
cord-342936-43u7afl3	164	16	Lycoris	Lycoris	NNP
cord-342936-43u7afl3	164	17	radiata	radiata	NN
cord-342936-43u7afl3	164	18	agglutinin	agglutinin	NNS
cord-342936-43u7afl3	164	19	(	(	-LRB-
cord-342936-43u7afl3	164	20	LRA	LRA	NNP
cord-342936-43u7afl3	164	21	)	)	-RRB-
cord-342936-43u7afl3	164	22	,	,	,
cord-342936-43u7afl3	164	23	Lycoris	Lycoris	NNP
cord-342936-43u7afl3	164	24	aurea	aurea	NN
cord-342936-43u7afl3	164	25	agglutinin	agglutinin	NNS
cord-342936-43u7afl3	164	26	(	(	-LRB-
cord-342936-43u7afl3	164	27	LAA	LAA	NNP
cord-342936-43u7afl3	164	28	)	)	-RRB-
cord-342936-43u7afl3	164	29	and	and	CC
cord-342936-43u7afl3	164	30	Zephyranthus	Zephyranthus	NNP
cord-342936-43u7afl3	164	31	grandiflora	grandiflora	NNP
cord-342936-43u7afl3	164	32	agglutinin	agglutinin	NNS
cord-342936-43u7afl3	164	33	(	(	-LRB-
cord-342936-43u7afl3	164	34	ZGA	ZGA	NNP
cord-342936-43u7afl3	164	35	)	)	-RRB-
cord-342936-43u7afl3	164	36	,	,	,
cord-342936-43u7afl3	164	37	all	all	DT
cord-342936-43u7afl3	164	38	of	of	IN
cord-342936-43u7afl3	164	39	which	which	WDT
cord-342936-43u7afl3	164	40	contain	contain	VBP
cord-342936-43u7afl3	164	41	three	three	CD
cord-342936-43u7afl3	164	42	mannose	mannose	NN
cord-342936-43u7afl3	164	43	-	-	HYPH
cord-342936-43u7afl3	164	44	binding	bind	VBG
cord-342936-43u7afl3	164	45	sites	site	NNS
cord-342936-43u7afl3	164	46	represented	represent	VBN
cord-342936-43u7afl3	164	47	by	by	IN
cord-342936-43u7afl3	164	48	the	the	DT
cord-342936-43u7afl3	164	49	conserved	conserve	VBN
cord-342936-43u7afl3	164	50	QXDXNXVXY	QXDXNXVXY	NNP
cord-342936-43u7afl3	164	51	motif	motif	NN
cord-342936-43u7afl3	164	52	.	.	.
cord-342936-43u7afl3	165	1	This	this	DT
cord-342936-43u7afl3	165	2	motif	motif	NN
cord-342936-43u7afl3	165	3	binds	bind	VBZ
cord-342936-43u7afl3	165	4	mannose	mannose	NN
cord-342936-43u7afl3	165	5	through	through	IN
cord-342936-43u7afl3	165	6	a	a	DT
cord-342936-43u7afl3	165	7	network	network	NN
cord-342936-43u7afl3	165	8	of	of	IN
cord-342936-43u7afl3	165	9	four	four	CD
cord-342936-43u7afl3	165	10	hydrogen	hydrogen	NN
cord-342936-43u7afl3	165	11	bonds	bond	NNS
cord-342936-43u7afl3	165	12	that	that	WDT
cord-342936-43u7afl3	165	13	interconnects	interconnect	VBZ
cord-342936-43u7afl3	165	14	the	the	DT
cord-342936-43u7afl3	165	15	hydroxyls	hydroxyls	NN
cord-342936-43u7afl3	165	16	of	of	IN
cord-342936-43u7afl3	165	17	C2	C2	NNP
cord-342936-43u7afl3	165	18	,	,	,
cord-342936-43u7afl3	165	19	C3	C3	NNP
cord-342936-43u7afl3	165	20	and	and	CC
cord-342936-43u7afl3	165	21	C4	c4	NN
cord-342936-43u7afl3	165	22	of	of	IN
cord-342936-43u7afl3	165	23	mannose	mannose	NN
cord-342936-43u7afl3	165	24	to	to	IN
cord-342936-43u7afl3	165	25	the	the	DT
cord-342936-43u7afl3	165	26	four	four	CD
cord-342936-43u7afl3	165	27	(	(	-LRB-
cord-342936-43u7afl3	165	28	QDNY	QDNY	NNP
cord-342936-43u7afl3	165	29	)	)	-RRB-
cord-342936-43u7afl3	165	30	amino	amino	NN
cord-342936-43u7afl3	165	31	-	-	HYPH
cord-342936-43u7afl3	165	32	acid	acid	NN
cord-342936-43u7afl3	165	33	residues	residue	NNS
cord-342936-43u7afl3	165	34	36,66	36,66	CD
cord-342936-43u7afl3	165	35	-	-	HYPH
cord-342936-43u7afl3	165	36	68	68	CD
cord-342936-43u7afl3	165	37	.	.	.
cord-342936-43u7afl3	166	1	A	a	DT
cord-342936-43u7afl3	166	2	valine	valine	NN
cord-342936-43u7afl3	166	3	present	present	NN
cord-342936-43u7afl3	166	4	within	within	IN
cord-342936-43u7afl3	166	5	this	this	DT
cord-342936-43u7afl3	166	6	motif	motif	NN
cord-342936-43u7afl3	166	7	also	also	RB
cord-342936-43u7afl3	166	8	interacts	interact	VBZ
cord-342936-43u7afl3	166	9	with	with	IN
cord-342936-43u7afl3	166	10	C3	C3	NNP
cord-342936-43u7afl3	166	11	and	and	CC
cord-342936-43u7afl3	166	12	C4	c4	NN
cord-342936-43u7afl3	166	13	of	of	IN
cord-342936-43u7afl3	166	14	mannose	mannose	NN
cord-342936-43u7afl3	166	15	through	through	IN
cord-342936-43u7afl3	166	16	van	van	NNP
cord-342936-43u7afl3	166	17	der	der	NNP
cord-342936-43u7afl3	166	18	Waals	Waals	NNP
cord-342936-43u7afl3	166	19	interactions	interaction	NNS
cord-342936-43u7afl3	166	20	.	.	.
cord-342936-43u7afl3	167	1	Interestingly	interestingly	RB
cord-342936-43u7afl3	167	2	,	,	,
cord-342936-43u7afl3	167	3	as	as	IN
cord-342936-43u7afl3	167	4	also	also	RB
cord-342936-43u7afl3	167	5	described	describe	VBN
cord-342936-43u7afl3	167	6	for	for	IN
cord-342936-43u7afl3	167	7	NPA	NPA	NNP
cord-342936-43u7afl3	167	8	,	,	,
cord-342936-43u7afl3	167	9	a	a	DT
cord-342936-43u7afl3	167	10	fourth	fourth	JJ
cord-342936-43u7afl3	167	11	mannose	mannose	NN
cord-342936-43u7afl3	167	12	-	-	HYPH
cord-342936-43u7afl3	167	13	binding	bind	VBG
cord-342936-43u7afl3	167	14	site	site	NN
cord-342936-43u7afl3	167	15	has	have	VBZ
cord-342936-43u7afl3	167	16	been	be	VBN
cord-342936-43u7afl3	167	17	found	find	VBN
cord-342936-43u7afl3	167	18	in	in	IN
cord-342936-43u7afl3	167	19	LAA	LAA	NNP
cord-342936-43u7afl3	167	20	near	near	IN
cord-342936-43u7afl3	167	21	the	the	DT
cord-342936-43u7afl3	167	22	tryptophane	tryptophane	NNP
cord-342936-43u7afl3	167	23	cluster	cluster	NN
cord-342936-43u7afl3	167	24	68	68	CD
cord-342936-43u7afl3	167	25	.	.	.
cord-342936-43u7afl3	168	1	Investigation	investigation	NN
cord-342936-43u7afl3	168	2	of	of	IN
cord-342936-43u7afl3	168	3	the	the	DT
cord-342936-43u7afl3	168	4	complex	complex	JJ
cord-342936-43u7afl3	168	5	molecular	molecular	JJ
cord-342936-43u7afl3	168	6	interactions	interaction	NNS
cord-342936-43u7afl3	168	7	of	of	IN
cord-342936-43u7afl3	168	8	CBAs	cba	NNS
cord-342936-43u7afl3	168	9	with	with	IN
cord-342936-43u7afl3	168	10	their	-PRON-	PRP$
cord-342936-43u7afl3	168	11	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	168	12	ligands	ligand	NNS
cord-342936-43u7afl3	168	13	should	should	MD
cord-342936-43u7afl3	168	14	enable	enable	VB
cord-342936-43u7afl3	168	15	the	the	DT
cord-342936-43u7afl3	168	16	rational	rational	JJ
cord-342936-43u7afl3	168	17	design	design	NN
cord-342936-43u7afl3	168	18	of	of	IN
cord-342936-43u7afl3	168	19	small	small	JJ
cord-342936-43u7afl3	168	20	-	-	HYPH
cord-342936-43u7afl3	168	21	size	size	NN
cord-342936-43u7afl3	168	22	molecules	molecule	NNS
cord-342936-43u7afl3	168	23	,	,	,
cord-342936-43u7afl3	168	24	including	include	VBG
cord-342936-43u7afl3	168	25	peptidomimetics	peptidomimetic	NNS
cord-342936-43u7afl3	168	26	.	.	.
cord-342936-43u7afl3	169	1	It	-PRON-	PRP
cord-342936-43u7afl3	169	2	is	be	VBZ
cord-342936-43u7afl3	169	3	obvious	obvious	JJ
cord-342936-43u7afl3	169	4	that	that	IN
cord-342936-43u7afl3	169	5	such	such	JJ
cord-342936-43u7afl3	169	6	low	low	JJ
cord-342936-43u7afl3	169	7	-	-	HYPH
cord-342936-43u7afl3	169	8	molecularweight	molecularweight	NN
cord-342936-43u7afl3	169	9	CBAs	cba	NNS
cord-342936-43u7afl3	169	10	will	will	MD
cord-342936-43u7afl3	169	11	,	,	,
cord-342936-43u7afl3	169	12	by	by	IN
cord-342936-43u7afl3	169	13	necessity	necessity	NN
cord-342936-43u7afl3	169	14	,	,	,
cord-342936-43u7afl3	169	15	have	have	VBP
cord-342936-43u7afl3	169	16	fewer	few	JJR
cord-342936-43u7afl3	169	17	interactions	interaction	NNS
cord-342936-43u7afl3	169	18	with	with	IN
cord-342936-43u7afl3	169	19	the	the	DT
cord-342936-43u7afl3	169	20	individual	individual	JJ
cord-342936-43u7afl3	169	21	carbohydrates	carbohydrate	NNS
cord-342936-43u7afl3	169	22	of	of	IN
cord-342936-43u7afl3	169	23	the	the	DT
cord-342936-43u7afl3	169	24	gp120	gp120	NNP
cord-342936-43u7afl3	169	25	glycans	glycan	NNS
cord-342936-43u7afl3	169	26	,	,	,
cord-342936-43u7afl3	169	27	and	and	CC
cord-342936-43u7afl3	169	28	thus	thus	RB
cord-342936-43u7afl3	169	29	may	may	MD
cord-342936-43u7afl3	169	30	display	display	VB
cord-342936-43u7afl3	169	31	a	a	DT
cord-342936-43u7afl3	169	32	lower	low	JJR
cord-342936-43u7afl3	169	33	affinity	affinity	NN
cord-342936-43u7afl3	169	34	towards	towards	IN
cord-342936-43u7afl3	169	35	the	the	DT
cord-342936-43u7afl3	169	36	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	169	37	oligomers	oligomer	NNS
cord-342936-43u7afl3	169	38	.	.	.
cord-342936-43u7afl3	170	1	However	however	RB
cord-342936-43u7afl3	170	2	,	,	,
cord-342936-43u7afl3	170	3	the	the	DT
cord-342936-43u7afl3	170	4	non	non	JJ
cord-342936-43u7afl3	170	5	-	-	JJ
cord-342936-43u7afl3	170	6	peptidic	peptidic	JJ
cord-342936-43u7afl3	170	7	small	small	JJ
cord-342936-43u7afl3	170	8	-	-	HYPH
cord-342936-43u7afl3	170	9	size	size	NN
cord-342936-43u7afl3	170	10	antibiotics	antibiotic	NNS
cord-342936-43u7afl3	170	11	PRM	PRM	NNP
cord-342936-43u7afl3	170	12	-	-	HYPH
cord-342936-43u7afl3	170	13	A	A	NNP
cord-342936-43u7afl3	170	14	and	and	CC
cord-342936-43u7afl3	170	15	BNM	BNM	NNP
cord-342936-43u7afl3	170	16	-	-	HYPH
cord-342936-43u7afl3	170	17	A	A	NNP
cord-342936-43u7afl3	170	18	(	(	-LRB-
cord-342936-43u7afl3	170	19	FIG	fig	NN
cord-342936-43u7afl3	170	20	.	.	.
cord-342936-43u7afl3	170	21	3	3	LS
cord-342936-43u7afl3	170	22	)	)	-RRB-
cord-342936-43u7afl3	170	23	have	have	VBP
cord-342936-43u7afl3	170	24	shown	show	VBN
cord-342936-43u7afl3	170	25	that	that	IN
cord-342936-43u7afl3	170	26	their	-PRON-	PRP$
cord-342936-43u7afl3	170	27	affinity	affinity	NN
cord-342936-43u7afl3	170	28	and	and	CC
cord-342936-43u7afl3	170	29	specificity	specificity	NN
cord-342936-43u7afl3	170	30	for	for	IN
cord-342936-43u7afl3	170	31	mannose	mannose	NN
cord-342936-43u7afl3	170	32	oligomers	oligomer	NNS
cord-342936-43u7afl3	170	33	are	be	VBP
cord-342936-43u7afl3	170	34	sufficiently	sufficiently	RB
cord-342936-43u7afl3	170	35	high	high	JJ
cord-342936-43u7afl3	170	36	to	to	TO
cord-342936-43u7afl3	170	37	enable	enable	VB
cord-342936-43u7afl3	170	38	an	an	DT
cord-342936-43u7afl3	170	39	efficient	efficient	JJ
cord-342936-43u7afl3	170	40	antiviral	antiviral	JJ
cord-342936-43u7afl3	170	41	activity	activity	NN
cord-342936-43u7afl3	170	42	.	.	.
cord-342936-43u7afl3	171	1	Unfortunately	unfortunately	RB
cord-342936-43u7afl3	171	2	,	,	,
cord-342936-43u7afl3	171	3	no	no	DT
cord-342936-43u7afl3	171	4	crystal	crystal	NN
cord-342936-43u7afl3	171	5	structures	structure	NNS
cord-342936-43u7afl3	171	6	have	have	VBP
cord-342936-43u7afl3	171	7	yet	yet	RB
cord-342936-43u7afl3	171	8	been	be	VBN
cord-342936-43u7afl3	171	9	obtained	obtain	VBN
cord-342936-43u7afl3	171	10	for	for	IN
cord-342936-43u7afl3	171	11	PRM	PRM	NNP
cord-342936-43u7afl3	171	12	-	-	HYPH
cord-342936-43u7afl3	171	13	A	A	NNP
cord-342936-43u7afl3	171	14	that	that	WDT
cord-342936-43u7afl3	171	15	allow	allow	VBP
cord-342936-43u7afl3	171	16	visualization	visualization	NN
cord-342936-43u7afl3	171	17	of	of	IN
cord-342936-43u7afl3	171	18	the	the	DT
cord-342936-43u7afl3	171	19	molecular	molecular	JJ
cord-342936-43u7afl3	171	20	interactions	interaction	NNS
cord-342936-43u7afl3	171	21	of	of	IN
cord-342936-43u7afl3	171	22	the	the	DT
cord-342936-43u7afl3	171	23	antibiotic	antibiotic	NN
cord-342936-43u7afl3	171	24	with	with	IN
cord-342936-43u7afl3	171	25	its	-PRON-	PRP$
cord-342936-43u7afl3	171	26	target	target	NN
cord-342936-43u7afl3	171	27	α(1,2)-mannose	α(1,2)-mannose	CD
cord-342936-43u7afl3	171	28	glycan	glycan	NN
cord-342936-43u7afl3	171	29	.	.	.
cord-342936-43u7afl3	172	1	If	if	IN
cord-342936-43u7afl3	172	2	such	such	JJ
cord-342936-43u7afl3	172	3	information	information	NN
cord-342936-43u7afl3	172	4	became	become	VBD
cord-342936-43u7afl3	172	5	available	available	JJ
cord-342936-43u7afl3	172	6	,	,	,
cord-342936-43u7afl3	172	7	further	further	JJ
cord-342936-43u7afl3	172	8	optimization	optimization	NN
cord-342936-43u7afl3	172	9	of	of	IN
cord-342936-43u7afl3	172	10	such	such	JJ
cord-342936-43u7afl3	172	11	CBAs	cba	NNS
cord-342936-43u7afl3	172	12	may	may	MD
cord-342936-43u7afl3	172	13	be	be	VB
cord-342936-43u7afl3	172	14	possible	possible	JJ
cord-342936-43u7afl3	172	15	.	.	.
cord-342936-43u7afl3	173	1	Numerous	numerous	JJ
cord-342936-43u7afl3	173	2	studies	study	NNS
cord-342936-43u7afl3	173	3	have	have	VBP
cord-342936-43u7afl3	173	4	shown	show	VBN
cord-342936-43u7afl3	173	5	that	that	IN
cord-342936-43u7afl3	173	6	CBAs	cba	NNS
cord-342936-43u7afl3	173	7	can	can	MD
cord-342936-43u7afl3	173	8	prevent	prevent	VB
cord-342936-43u7afl3	173	9	HIV	HIV	NNP
cord-342936-43u7afl3	173	10	infection	infection	NN
cord-342936-43u7afl3	173	11	of	of	IN
cord-342936-43u7afl3	173	12	cell	cell	NN
cord-342936-43u7afl3	173	13	cultures	culture	NNS
cord-342936-43u7afl3	173	14	.	.	.
cord-342936-43u7afl3	174	1	This	this	DT
cord-342936-43u7afl3	174	2	has	have	VBZ
cord-342936-43u7afl3	174	3	been	be	VBN
cord-342936-43u7afl3	174	4	shown	show	VBN
cord-342936-43u7afl3	174	5	for	for	IN
cord-342936-43u7afl3	174	6	many	many	JJ
cord-342936-43u7afl3	174	7	virus	virus	NN
cord-342936-43u7afl3	174	8	strains	strain	NNS
cord-342936-43u7afl3	174	9	(	(	-LRB-
cord-342936-43u7afl3	174	10	including	include	VBG
cord-342936-43u7afl3	174	11	laboratory	laboratory	NN
cord-342936-43u7afl3	174	12	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	174	13	and	and	CC
cord-342936-43u7afl3	174	14	HIV-2	HIV-2	NNP
cord-342936-43u7afl3	174	15	strains	strain	NNS
cord-342936-43u7afl3	174	16	,	,	,
cord-342936-43u7afl3	174	17	members	member	NNS
cord-342936-43u7afl3	174	18	of	of	IN
cord-342936-43u7afl3	174	19	Group	Group	NNP
cord-342936-43u7afl3	174	20	O	O	NNP
cord-342936-43u7afl3	174	21	and	and	CC
cord-342936-43u7afl3	174	22	different	different	JJ
cord-342936-43u7afl3	174	23	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	174	24	clades	clade	NNS
cord-342936-43u7afl3	174	25	)	)	-RRB-
cord-342936-43u7afl3	174	26	that	that	WDT
cord-342936-43u7afl3	174	27	infect	infect	VBP
cord-342936-43u7afl3	174	28	many	many	JJ
cord-342936-43u7afl3	174	29	different	different	JJ
cord-342936-43u7afl3	174	30	target	target	NN
cord-342936-43u7afl3	174	31	cells	cell	NNS
cord-342936-43u7afl3	174	32	(	(	-LRB-
cord-342936-43u7afl3	174	33	including	include	VBG
cord-342936-43u7afl3	174	34	laboratory	laboratory	NN
cord-342936-43u7afl3	174	35	cell	cell	NN
cord-342936-43u7afl3	174	36	lines	line	NNS
cord-342936-43u7afl3	174	37	,	,	,
cord-342936-43u7afl3	174	38	peripheral	peripheral	JJ
cord-342936-43u7afl3	174	39	-	-	HYPH
cord-342936-43u7afl3	174	40	blood	blood	NN
cord-342936-43u7afl3	174	41	mononuclear	mononuclear	NN
cord-342936-43u7afl3	174	42	cells	cell	NNS
cord-342936-43u7afl3	174	43	(	(	-LRB-
cord-342936-43u7afl3	174	44	PBMCs	pbmc	NNS
cord-342936-43u7afl3	174	45	)	)	-RRB-
cord-342936-43u7afl3	174	46	,	,	,
cord-342936-43u7afl3	174	47	macrophages	macrophage	NNS
cord-342936-43u7afl3	174	48	and	and	CC
cord-342936-43u7afl3	174	49	DCs	DCs	NNP
cord-342936-43u7afl3	174	50	)	)	-RRB-
cord-342936-43u7afl3	174	51	.	.	.
cord-342936-43u7afl3	175	1	Inhibition	inhibition	NN
cord-342936-43u7afl3	175	2	of	of	IN
cord-342936-43u7afl3	175	3	HIV	HIV	NNP
cord-342936-43u7afl3	175	4	infection	infection	NN
cord-342936-43u7afl3	175	5	by	by	IN
cord-342936-43u7afl3	175	6	CBAs	cba	NNS
cord-342936-43u7afl3	175	7	occurs	occur	VBZ
cord-342936-43u7afl3	175	8	at	at	IN
cord-342936-43u7afl3	175	9	50	50	CD
cord-342936-43u7afl3	175	10	%	%	NN
cord-342936-43u7afl3	175	11	effective	effective	JJ
cord-342936-43u7afl3	175	12	concentrations	concentration	NNS
cord-342936-43u7afl3	175	13	that	that	WDT
cord-342936-43u7afl3	175	14	rank	rank	VBP
cord-342936-43u7afl3	175	15	between	between	IN
cord-342936-43u7afl3	175	16	the	the	DT
cord-342936-43u7afl3	175	17	lower	low	JJR
cord-342936-43u7afl3	175	18	nanomolar	nanomolar	JJ
cord-342936-43u7afl3	175	19	and	and	CC
cord-342936-43u7afl3	175	20	micromolar	micromolar	JJ
cord-342936-43u7afl3	175	21	ranges	range	NNS
cord-342936-43u7afl3	175	22	.	.	.
cord-342936-43u7afl3	176	1	The	the	DT
cord-342936-43u7afl3	176	2	antiviral	antiviral	JJ
cord-342936-43u7afl3	176	3	activity	activity	NN
cord-342936-43u7afl3	176	4	will	will	MD
cord-342936-43u7afl3	176	5	also	also	RB
cord-342936-43u7afl3	176	6	depend	depend	VB
cord-342936-43u7afl3	176	7	on	on	IN
cord-342936-43u7afl3	176	8	the	the	DT
cord-342936-43u7afl3	176	9	nature	nature	NN
cord-342936-43u7afl3	176	10	of	of	IN
cord-342936-43u7afl3	176	11	the	the	DT
cord-342936-43u7afl3	176	12	CBA	CBA	NNP
cord-342936-43u7afl3	176	13	and	and	CC
cord-342936-43u7afl3	176	14	the	the	DT
cord-342936-43u7afl3	176	15	virus	virus	NN
cord-342936-43u7afl3	176	16	strains	strain	NNS
cord-342936-43u7afl3	176	17	that	that	WDT
cord-342936-43u7afl3	176	18	are	be	VBP
cord-342936-43u7afl3	176	19	investigated	investigate	VBN
cord-342936-43u7afl3	176	20	18	18	CD
cord-342936-43u7afl3	176	21	,	,	,
cord-342936-43u7afl3	176	22	26	26	CD
cord-342936-43u7afl3	176	23	,	,	,
cord-342936-43u7afl3	176	24	[	[	-LRB-
cord-342936-43u7afl3	176	25	30	30	CD
cord-342936-43u7afl3	176	26	]	]	-RRB-
cord-342936-43u7afl3	176	27	[	[	-LRB-
cord-342936-43u7afl3	176	28	31	31	CD
cord-342936-43u7afl3	176	29	]	]	-RRB-
cord-342936-43u7afl3	176	30	[	[	-LRB-
cord-342936-43u7afl3	176	31	32	32	CD
cord-342936-43u7afl3	176	32	]	]	-RRB-
cord-342936-43u7afl3	176	33	[	[	-LRB-
cord-342936-43u7afl3	176	34	38	38	CD
cord-342936-43u7afl3	176	35	]	]	-RRB-
cord-342936-43u7afl3	176	36	[	[	-LRB-
cord-342936-43u7afl3	176	37	39	39	CD
cord-342936-43u7afl3	176	38	]	]	-RRB-
cord-342936-43u7afl3	176	39	[	[	-LRB-
cord-342936-43u7afl3	176	40	40	40	CD
cord-342936-43u7afl3	176	41	]	]	-RRB-
cord-342936-43u7afl3	177	1	[	[	-LRB-
cord-342936-43u7afl3	177	2	41	41	CD
cord-342936-43u7afl3	177	3	]	]	-RRB-
cord-342936-43u7afl3	177	4	58	58	CD
cord-342936-43u7afl3	177	5	,	,	,
cord-342936-43u7afl3	177	6	60	60	CD
cord-342936-43u7afl3	177	7	,	,	,
cord-342936-43u7afl3	177	8	63	63	CD
cord-342936-43u7afl3	177	9	,	,	,
cord-342936-43u7afl3	177	10	69	69	CD
cord-342936-43u7afl3	177	11	,	,	,
cord-342936-43u7afl3	177	12	72	72	CD
cord-342936-43u7afl3	177	13	.	.	.
cord-342936-43u7afl3	178	1	Although	although	IN
cord-342936-43u7afl3	178	2	most	most	JJS
cord-342936-43u7afl3	178	3	studies	study	NNS
cord-342936-43u7afl3	178	4	have	have	VBP
cord-342936-43u7afl3	178	5	been	be	VBN
cord-342936-43u7afl3	178	6	performed	perform	VBN
cord-342936-43u7afl3	178	7	with	with	IN
cord-342936-43u7afl3	178	8	laboratory	laboratory	NN
cord-342936-43u7afl3	178	9	virus	virus	NN
cord-342936-43u7afl3	178	10	strains	strain	NNS
cord-342936-43u7afl3	178	11	that	that	WDT
cord-342936-43u7afl3	178	12	are	be	VBP
cord-342936-43u7afl3	178	13	adapted	adapt	VBN
cord-342936-43u7afl3	178	14	to	to	IN
cord-342936-43u7afl3	178	15	growth	growth	NN
cord-342936-43u7afl3	178	16	in	in	IN
cord-342936-43u7afl3	178	17	immortalized	immortalize	VBN
cord-342936-43u7afl3	178	18	cell	cell	NN
cord-342936-43u7afl3	178	19	lines	line	NNS
cord-342936-43u7afl3	178	20	(	(	-LRB-
cord-342936-43u7afl3	178	21	such	such	JJ
cord-342936-43u7afl3	178	22	as	as	IN
cord-342936-43u7afl3	178	23	MT-4	MT-4	NNP
cord-342936-43u7afl3	178	24	,	,	,
cord-342936-43u7afl3	178	25	CEM	CEM	NNP
cord-342936-43u7afl3	178	26	and	and	CC
cord-342936-43u7afl3	178	27	Molt	Molt	NNP
cord-342936-43u7afl3	178	28	)	)	-RRB-
cord-342936-43u7afl3	178	29	,	,	,
cord-342936-43u7afl3	178	30	several	several	JJ
cord-342936-43u7afl3	178	31	other	other	JJ
cord-342936-43u7afl3	178	32	studies	study	NNS
cord-342936-43u7afl3	178	33	have	have	VBP
cord-342936-43u7afl3	178	34	shown	show	VBN
cord-342936-43u7afl3	178	35	the	the	DT
cord-342936-43u7afl3	178	36	pronounced	pronounced	JJ
cord-342936-43u7afl3	178	37	activity	activity	NN
cord-342936-43u7afl3	178	38	of	of	IN
cord-342936-43u7afl3	178	39	CBAs	cba	NNS
cord-342936-43u7afl3	178	40	against	against	IN
cord-342936-43u7afl3	178	41	different	different	JJ
cord-342936-43u7afl3	178	42	virus	virus	NN
cord-342936-43u7afl3	178	43	clade	clade	NN
cord-342936-43u7afl3	178	44	isolates	isolate	VBZ
cord-342936-43u7afl3	178	45	in	in	IN
cord-342936-43u7afl3	178	46	PBMC	PBMC	NNP
cord-342936-43u7afl3	178	47	cultures	culture	NNS
cord-342936-43u7afl3	178	48	or	or	CC
cord-342936-43u7afl3	178	49	against	against	IN
cord-342936-43u7afl3	178	50	the	the	DT
cord-342936-43u7afl3	178	51	R5-HIV-1	R5-HIV-1	NNP
cord-342936-43u7afl3	178	52	strain	strain	VB
cord-342936-43u7afl3	178	53	Ba	Ba	NNP
cord-342936-43u7afl3	178	54	-	-	HYPH
cord-342936-43u7afl3	178	55	L	L	NNP
cord-342936-43u7afl3	178	56	in	in	IN
cord-342936-43u7afl3	178	57	primary	primary	JJ
cord-342936-43u7afl3	178	58	macrophage	macrophage	NN
cord-342936-43u7afl3	178	59	cell	cell	NN
cord-342936-43u7afl3	178	60	cultures	culture	NNS
cord-342936-43u7afl3	178	61	41	41	CD
cord-342936-43u7afl3	178	62	,	,	,
cord-342936-43u7afl3	178	63	60	60	CD
cord-342936-43u7afl3	178	64	,	,	,
cord-342936-43u7afl3	178	65	69	69	CD
cord-342936-43u7afl3	178	66	,	,	,
cord-342936-43u7afl3	178	67	71	71	CD
cord-342936-43u7afl3	178	68	.	.	.
cord-342936-43u7afl3	179	1	The	the	DT
cord-342936-43u7afl3	179	2	size	size	NN
cord-342936-43u7afl3	179	3	of	of	IN
cord-342936-43u7afl3	179	4	the	the	DT
cord-342936-43u7afl3	179	5	CBAs	cba	NNS
cord-342936-43u7afl3	179	6	and	and	CC
cord-342936-43u7afl3	179	7	their	-PRON-	PRP$
cord-342936-43u7afl3	179	8	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	179	9	specificity	specificity	NN
cord-342936-43u7afl3	179	10	seem	seem	VBP
cord-342936-43u7afl3	179	11	to	to	TO
cord-342936-43u7afl3	179	12	have	have	VB
cord-342936-43u7afl3	179	13	an	an	DT
cord-342936-43u7afl3	179	14	important	important	JJ
cord-342936-43u7afl3	179	15	role	role	NN
cord-342936-43u7afl3	179	16	in	in	IN
cord-342936-43u7afl3	179	17	their	-PRON-	PRP$
cord-342936-43u7afl3	179	18	eventual	eventual	JJ
cord-342936-43u7afl3	179	19	potency	potency	NN
cord-342936-43u7afl3	179	20	and	and	CC
cord-342936-43u7afl3	179	21	antiviral	antiviral	JJ
cord-342936-43u7afl3	179	22	efficacy	efficacy	NN
cord-342936-43u7afl3	179	23	.	.	.
cord-342936-43u7afl3	180	1	In	in	IN
cord-342936-43u7afl3	180	2	general	general	JJ
cord-342936-43u7afl3	180	3	,	,	,
cord-342936-43u7afl3	180	4	whereas	whereas	IN
cord-342936-43u7afl3	180	5	most	most	JJS
cord-342936-43u7afl3	180	6	mannose	mannose	NN
cord-342936-43u7afl3	180	7	-	-	HYPH
cord-342936-43u7afl3	180	8	specific	specific	JJ
cord-342936-43u7afl3	180	9	CBAs	cba	NNS
cord-342936-43u7afl3	180	10	are	be	VBP
cord-342936-43u7afl3	180	11	inhibitory	inhibitory	JJ
cord-342936-43u7afl3	180	12	to	to	IN
cord-342936-43u7afl3	180	13	HIV	HIV	NNP
cord-342936-43u7afl3	180	14	,	,	,
cord-342936-43u7afl3	180	15	UDA	UDA	NNP
cord-342936-43u7afl3	180	16	is	be	VBZ
cord-342936-43u7afl3	180	17	the	the	DT
cord-342936-43u7afl3	180	18	only	only	JJ
cord-342936-43u7afl3	180	19	example	example	NN
cord-342936-43u7afl3	180	20	of	of	IN
cord-342936-43u7afl3	180	21	an	an	DT
cord-342936-43u7afl3	180	22	HIV-1-active	hiv-1-active	JJ
cord-342936-43u7afl3	180	23	GlcNAc	glcnac	NN
cord-342936-43u7afl3	180	24	-	-	HYPH
cord-342936-43u7afl3	180	25	specific	specific	JJ
cord-342936-43u7afl3	180	26	lectin	lectin	NN
cord-342936-43u7afl3	180	27	,	,	,
cord-342936-43u7afl3	180	28	and	and	CC
cord-342936-43u7afl3	180	29	poor	poor	JJ
cord-342936-43u7afl3	180	30	,	,	,
cord-342936-43u7afl3	180	31	if	if	IN
cord-342936-43u7afl3	180	32	any	any	DT
cord-342936-43u7afl3	180	33	,	,	,
cord-342936-43u7afl3	180	34	anti	anti	JJ
cord-342936-43u7afl3	180	35	-	-	JJ
cord-342936-43u7afl3	180	36	HIV	hiv	JJ
cord-342936-43u7afl3	180	37	activity	activity	NN
cord-342936-43u7afl3	180	38	has	have	VBZ
cord-342936-43u7afl3	180	39	been	be	VBN
cord-342936-43u7afl3	180	40	reported	report	VBN
cord-342936-43u7afl3	180	41	for	for	IN
cord-342936-43u7afl3	180	42	lectins	lectin	NNS
cord-342936-43u7afl3	180	43	with	with	IN
cord-342936-43u7afl3	180	44	other	other	JJ
cord-342936-43u7afl3	180	45	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	180	46	specificities	specificity	NNS
cord-342936-43u7afl3	180	47	72	72	CD
cord-342936-43u7afl3	180	48	.	.	.
cord-342936-43u7afl3	181	1	Interestingly	interestingly	RB
cord-342936-43u7afl3	181	2	,	,	,
cord-342936-43u7afl3	181	3	CBAs	cba	NNS
cord-342936-43u7afl3	181	4	that	that	WDT
cord-342936-43u7afl3	181	5	are	be	VBP
cord-342936-43u7afl3	181	6	assumed	assume	VBN
cord-342936-43u7afl3	181	7	to	to	TO
cord-342936-43u7afl3	181	8	have	have	VB
cord-342936-43u7afl3	181	9	a	a	DT
cord-342936-43u7afl3	181	10	well	well	RB
cord-342936-43u7afl3	181	11	-	-	HYPH
cord-342936-43u7afl3	181	12	defined	define	VBN
cord-342936-43u7afl3	181	13	glycan	glycan	NN
cord-342936-43u7afl3	181	14	specificity	specificity	NN
cord-342936-43u7afl3	181	15	may	may	MD
cord-342936-43u7afl3	181	16	still	still	RB
cord-342936-43u7afl3	181	17	differ	differ	VB
cord-342936-43u7afl3	181	18	considerably	considerably	RB
cord-342936-43u7afl3	181	19	in	in	IN
cord-342936-43u7afl3	181	20	antiviral	antiviral	JJ
cord-342936-43u7afl3	181	21	potency	potency	NN
cord-342936-43u7afl3	181	22	,	,	,
cord-342936-43u7afl3	181	23	although	although	IN
cord-342936-43u7afl3	181	24	this	this	DT
cord-342936-43u7afl3	181	25	phenomenon	phenomenon	NN
cord-342936-43u7afl3	181	26	is	be	VBZ
cord-342936-43u7afl3	181	27	not	not	RB
cord-342936-43u7afl3	181	28	well	well	RB
cord-342936-43u7afl3	181	29	understood	understand	VBN
cord-342936-43u7afl3	181	30	.	.	.
cord-342936-43u7afl3	182	1	It	-PRON-	PRP
cord-342936-43u7afl3	182	2	is	be	VBZ
cord-342936-43u7afl3	182	3	clear	clear	JJ
cord-342936-43u7afl3	182	4	,	,	,
cord-342936-43u7afl3	182	5	however	however	RB
cord-342936-43u7afl3	182	6	,	,	,
cord-342936-43u7afl3	182	7	that	that	IN
cord-342936-43u7afl3	182	8	subtle	subtle	JJ
cord-342936-43u7afl3	182	9	differences	difference	NNS
cord-342936-43u7afl3	182	10	in	in	IN
cord-342936-43u7afl3	182	11	their	-PRON-	PRP$
cord-342936-43u7afl3	182	12	three	three	CD
cord-342936-43u7afl3	182	13	-	-	HYPH
cord-342936-43u7afl3	182	14	dimensional	dimensional	JJ
cord-342936-43u7afl3	182	15	conformation	conformation	NN
cord-342936-43u7afl3	182	16	,	,	,
cord-342936-43u7afl3	182	17	as	as	RB
cord-342936-43u7afl3	182	18	well	well	RB
cord-342936-43u7afl3	182	19	as	as	IN
cord-342936-43u7afl3	182	20	the	the	DT
cord-342936-43u7afl3	182	21	proper	proper	JJ
cord-342936-43u7afl3	182	22	steric	steric	JJ
cord-342936-43u7afl3	182	23	availability	availability	NN
cord-342936-43u7afl3	182	24	of	of	IN
cord-342936-43u7afl3	182	25	the	the	DT
cord-342936-43u7afl3	182	26	glycans	glycan	NNS
cord-342936-43u7afl3	182	27	that	that	WDT
cord-342936-43u7afl3	182	28	efficiently	efficiently	RB
cord-342936-43u7afl3	182	29	interact	interact	VBP
cord-342936-43u7afl3	182	30	with	with	IN
cord-342936-43u7afl3	182	31	CBAs	cba	NNS
cord-342936-43u7afl3	182	32	and	and	CC
cord-342936-43u7afl3	182	33	the	the	DT
cord-342936-43u7afl3	182	34	presence	presence	NN
cord-342936-43u7afl3	182	35	,	,	,
cord-342936-43u7afl3	182	36	or	or	CC
cord-342936-43u7afl3	182	37	lack	lack	NN
cord-342936-43u7afl3	182	38	,	,	,
cord-342936-43u7afl3	182	39	of	of	IN
cord-342936-43u7afl3	182	40	well	well	RB
cord-342936-43u7afl3	182	41	-	-	HYPH
cord-342936-43u7afl3	182	42	defined	define	VBN
cord-342936-43u7afl3	182	43	glycan	glycan	NN
cord-342936-43u7afl3	182	44	conformations	conformation	NNS
cord-342936-43u7afl3	182	45	on	on	IN
cord-342936-43u7afl3	182	46	the	the	DT
cord-342936-43u7afl3	182	47	viral	viral	JJ
cord-342936-43u7afl3	182	48	envelope	envelope	NN
cord-342936-43u7afl3	182	49	,	,	,
cord-342936-43u7afl3	182	50	have	have	VBP
cord-342936-43u7afl3	182	51	an	an	DT
cord-342936-43u7afl3	182	52	important	important	JJ
cord-342936-43u7afl3	182	53	role	role	NN
cord-342936-43u7afl3	182	54	in	in	IN
cord-342936-43u7afl3	182	55	the	the	DT
cord-342936-43u7afl3	182	56	eventual	eventual	JJ
cord-342936-43u7afl3	182	57	antiviral	antiviral	JJ
cord-342936-43u7afl3	182	58	efficacy	efficacy	NN
cord-342936-43u7afl3	182	59	of	of	IN
cord-342936-43u7afl3	182	60	CBAs	cba	NNS
cord-342936-43u7afl3	182	61	.	.	.
cord-342936-43u7afl3	183	1	The	the	DT
cord-342936-43u7afl3	183	2	formation	formation	NN
cord-342936-43u7afl3	183	3	of	of	IN
cord-342936-43u7afl3	183	4	syncytial	syncytial	JJ
cord-342936-43u7afl3	183	5	giant	giant	JJ
cord-342936-43u7afl3	183	6	cells	cell	NNS
cord-342936-43u7afl3	183	7	between	between	IN
cord-342936-43u7afl3	183	8	cells	cell	NNS
cord-342936-43u7afl3	183	9	persistently	persistently	RB
cord-342936-43u7afl3	183	10	infected	infect	VBN
cord-342936-43u7afl3	183	11	with	with	IN
cord-342936-43u7afl3	183	12	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	183	13	and	and	CC
cord-342936-43u7afl3	183	14	uninfected	uninfected	JJ
cord-342936-43u7afl3	183	15	cells	cell	NNS
cord-342936-43u7afl3	183	16	can	can	MD
cord-342936-43u7afl3	183	17	also	also	RB
cord-342936-43u7afl3	183	18	be	be	VB
cord-342936-43u7afl3	183	19	efficiently	efficiently	RB
cord-342936-43u7afl3	183	20	prevented	prevent	VBN
cord-342936-43u7afl3	183	21	by	by	IN
cord-342936-43u7afl3	183	22	CBAs	cba	NNS
cord-342936-43u7afl3	183	23	40	40	CD
cord-342936-43u7afl3	183	24	.	.	.
cord-342936-43u7afl3	184	1	Inhibition	inhibition	NN
cord-342936-43u7afl3	184	2	of	of	IN
cord-342936-43u7afl3	184	3	giant	giant	JJ
cord-342936-43u7afl3	184	4	-	-	HYPH
cord-342936-43u7afl3	184	5	cell	cell	NN
cord-342936-43u7afl3	184	6	formation	formation	NN
cord-342936-43u7afl3	184	7	in	in	IN
cord-342936-43u7afl3	184	8	HIV-1-infected	hiv-1-infected	JJ
cord-342936-43u7afl3	184	9	and	and	CC
cord-342936-43u7afl3	184	10	non	non	JJ
cord-342936-43u7afl3	184	11	-	-	JJ
cord-342936-43u7afl3	184	12	infected	infected	JJ
cord-342936-43u7afl3	184	13	T	t	NN
cord-342936-43u7afl3	184	14	-	-	HYPH
cord-342936-43u7afl3	184	15	cell	cell	NN
cord-342936-43u7afl3	184	16	co	co	NNS
cord-342936-43u7afl3	184	17	-	-	NNS
cord-342936-43u7afl3	184	18	cultures	culture	NNS
cord-342936-43u7afl3	184	19	usually	usually	RB
cord-342936-43u7afl3	184	20	requires	require	VBZ
cord-342936-43u7afl3	184	21	CBA	CBA	NNP
cord-342936-43u7afl3	184	22	concentrations	concentration	NNS
cord-342936-43u7afl3	184	23	that	that	WDT
cord-342936-43u7afl3	184	24	are	be	VBP
cord-342936-43u7afl3	184	25	five	five	CD
cord-342936-43u7afl3	184	26	to	to	IN
cord-342936-43u7afl3	184	27	tenfold	tenfold	RB
cord-342936-43u7afl3	184	28	higher	high	JJR
cord-342936-43u7afl3	184	29	than	than	IN
cord-342936-43u7afl3	184	30	those	those	DT
cord-342936-43u7afl3	184	31	needed	need	VBN
cord-342936-43u7afl3	184	32	for	for	IN
cord-342936-43u7afl3	184	33	inhibition	inhibition	NN
cord-342936-43u7afl3	184	34	of	of	IN
cord-342936-43u7afl3	184	35	cell	cell	NN
cord-342936-43u7afl3	184	36	-	-	HYPH
cord-342936-43u7afl3	184	37	free	free	JJ
cord-342936-43u7afl3	184	38	virus	virus	NN
cord-342936-43u7afl3	184	39	infection	infection	NN
cord-342936-43u7afl3	184	40	of	of	IN
cord-342936-43u7afl3	184	41	the	the	DT
cord-342936-43u7afl3	184	42	target	target	NN
cord-342936-43u7afl3	184	43	cells	cell	NNS
cord-342936-43u7afl3	184	44	.	.	.
cord-342936-43u7afl3	185	1	Some	some	DT
cord-342936-43u7afl3	185	2	CBAs	cba	NNS
cord-342936-43u7afl3	185	3	(	(	-LRB-
cord-342936-43u7afl3	185	4	such	such	JJ
cord-342936-43u7afl3	185	5	as	as	IN
cord-342936-43u7afl3	185	6	the	the	DT
cord-342936-43u7afl3	185	7	non	non	JJ
cord-342936-43u7afl3	185	8	-	-	JJ
cord-342936-43u7afl3	185	9	peptidic	peptidic	JJ
cord-342936-43u7afl3	185	10	PRM	PRM	NNP
cord-342936-43u7afl3	185	11	-	-	HYPH
cord-342936-43u7afl3	185	12	A	A	NNP
cord-342936-43u7afl3	185	13	)	)	-RRB-
cord-342936-43u7afl3	185	14	,	,	,
cord-342936-43u7afl3	185	15	however	however	RB
cord-342936-43u7afl3	185	16	,	,	,
cord-342936-43u7afl3	185	17	are	be	VBP
cord-342936-43u7afl3	185	18	equally	equally	RB
cord-342936-43u7afl3	185	19	effective	effective	JJ
cord-342936-43u7afl3	185	20	in	in	IN
cord-342936-43u7afl3	185	21	their	-PRON-	PRP$
cord-342936-43u7afl3	185	22	inhibitory	inhibitory	JJ
cord-342936-43u7afl3	185	23	potential	potential	NN
cord-342936-43u7afl3	185	24	for	for	IN
cord-342936-43u7afl3	185	25	both	both	DT
cord-342936-43u7afl3	185	26	modes	mode	NNS
cord-342936-43u7afl3	185	27	of	of	IN
cord-342936-43u7afl3	185	28	viral	viral	JJ
cord-342936-43u7afl3	185	29	transmission	transmission	NN
cord-342936-43u7afl3	185	30	60	60	CD
cord-342936-43u7afl3	185	31	.	.	.
cord-342936-43u7afl3	186	1	Recently	recently	RB
cord-342936-43u7afl3	186	2	,	,	,
cord-342936-43u7afl3	186	3	it	-PRON-	PRP
cord-342936-43u7afl3	186	4	was	be	VBD
cord-342936-43u7afl3	186	5	shown	show	VBN
cord-342936-43u7afl3	186	6	that	that	IN
cord-342936-43u7afl3	186	7	CBAs	cba	NNS
cord-342936-43u7afl3	186	8	inhibit	inhibit	VBP
cord-342936-43u7afl3	186	9	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	186	10	infection	infection	NN
cord-342936-43u7afl3	186	11	of	of	IN
cord-342936-43u7afl3	186	12	DCs	DCs	NNP
cord-342936-43u7afl3	186	13	and	and	CC
cord-342936-43u7afl3	186	14	DC	DC	NNP
cord-342936-43u7afl3	186	15	-	-	HYPH
cord-342936-43u7afl3	186	16	directed	direct	VBN
cord-342936-43u7afl3	186	17	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	186	18	transfer	transfer	NN
cord-342936-43u7afl3	186	19	71	71	CD
cord-342936-43u7afl3	186	20	.	.	.
cord-342936-43u7afl3	187	1	It	-PRON-	PRP
cord-342936-43u7afl3	187	2	has	have	VBZ
cord-342936-43u7afl3	187	3	also	also	RB
cord-342936-43u7afl3	187	4	been	be	VBN
cord-342936-43u7afl3	187	5	demonstrated	demonstrate	VBN
cord-342936-43u7afl3	187	6	that	that	IN
cord-342936-43u7afl3	187	7	CBAs	cba	NNS
cord-342936-43u7afl3	187	8	have	have	VBP
cord-342936-43u7afl3	187	9	a	a	DT
cord-342936-43u7afl3	187	10	pronounced	pronounce	VBN
cord-342936-43u7afl3	187	11	inhibitory	inhibitory	JJ
cord-342936-43u7afl3	187	12	effect	effect	NN
cord-342936-43u7afl3	187	13	on	on	IN
cord-342936-43u7afl3	187	14	virus	virus	NN
cord-342936-43u7afl3	187	15	capture	capture	NN
cord-342936-43u7afl3	187	16	by	by	IN
cord-342936-43u7afl3	187	17	cells	cell	NNS
cord-342936-43u7afl3	187	18	that	that	WDT
cord-342936-43u7afl3	187	19	express	express	VBP
cord-342936-43u7afl3	187	20	DC	DC	NNP
cord-342936-43u7afl3	187	21	-	-	HYPH
cord-342936-43u7afl3	187	22	SIGN	SIGN	NNP
cord-342936-43u7afl3	187	23	and	and	CC
cord-342936-43u7afl3	187	24	on	on	IN
cord-342936-43u7afl3	187	25	the	the	DT
cord-342936-43u7afl3	187	26	subsequent	subsequent	JJ
cord-342936-43u7afl3	187	27	transmission	transmission	NN
cord-342936-43u7afl3	187	28	of	of	IN
cord-342936-43u7afl3	187	29	the	the	DT
cord-342936-43u7afl3	187	30	virus	virus	NN
cord-342936-43u7afl3	187	31	to	to	IN
cord-342936-43u7afl3	187	32	uninfected	uninfected	JJ
cord-342936-43u7afl3	187	33	T	t	NN
cord-342936-43u7afl3	187	34	cells	cell	NNS
cord-342936-43u7afl3	187	35	73	73	CD
cord-342936-43u7afl3	187	36	.	.	.
cord-342936-43u7afl3	188	1	DC	DC	NNP
cord-342936-43u7afl3	188	2	-	-	HYPH
cord-342936-43u7afl3	188	3	SIGN	SIGN	NNP
cord-342936-43u7afl3	188	4	is	be	VBZ
cord-342936-43u7afl3	188	5	a	a	DT
cord-342936-43u7afl3	188	6	natural	natural	JJ
cord-342936-43u7afl3	188	7	C	c	NN
cord-342936-43u7afl3	188	8	-	-	HYPH
cord-342936-43u7afl3	188	9	type	type	NN
cord-342936-43u7afl3	188	10	lectin	lectin	NN
cord-342936-43u7afl3	188	11	that	that	WDT
cord-342936-43u7afl3	188	12	has	have	VBZ
cord-342936-43u7afl3	188	13	a	a	DT
cord-342936-43u7afl3	188	14	pivotal	pivotal	JJ
cord-342936-43u7afl3	188	15	role	role	NN
cord-342936-43u7afl3	188	16	in	in	IN
cord-342936-43u7afl3	188	17	innate	innate	JJ
cord-342936-43u7afl3	188	18	immune	immune	JJ
cord-342936-43u7afl3	188	19	defence	defence	NN
cord-342936-43u7afl3	188	20	46	46	CD
cord-342936-43u7afl3	189	1	(	(	-LRB-
cord-342936-43u7afl3	189	2	BOX1	BOX1	NNP
cord-342936-43u7afl3	189	3	;	;	:
cord-342936-43u7afl3	189	4	FIG	fig	NN
cord-342936-43u7afl3	189	5	.	.	.
cord-342936-43u7afl3	189	6	1	1	CD
cord-342936-43u7afl3	189	7	)	)	-RRB-
cord-342936-43u7afl3	189	8	.	.	.
cord-342936-43u7afl3	190	1	To	to	TO
cord-342936-43u7afl3	190	2	eliminate	eliminate	VB
cord-342936-43u7afl3	190	3	the	the	DT
cord-342936-43u7afl3	190	4	pathogen	pathogen	NN
cord-342936-43u7afl3	190	5	from	from	IN
cord-342936-43u7afl3	190	6	the	the	DT
cord-342936-43u7afl3	190	7	infected	infected	JJ
cord-342936-43u7afl3	190	8	host	host	NN
cord-342936-43u7afl3	190	9	,	,	,
cord-342936-43u7afl3	190	10	DC	DC	NNP
cord-342936-43u7afl3	190	11	-	-	HYPH
cord-342936-43u7afl3	190	12	SIGN	SIGN	NNP
cord-342936-43u7afl3	190	13	captures	capture	VBZ
cord-342936-43u7afl3	190	14	pathogens	pathogen	NNS
cord-342936-43u7afl3	190	15	such	such	JJ
cord-342936-43u7afl3	190	16	as	as	IN
cord-342936-43u7afl3	190	17	HIV	HIV	NNP
cord-342936-43u7afl3	190	18	through	through	IN
cord-342936-43u7afl3	190	19	its	-PRON-	PRP$
cord-342936-43u7afl3	190	20	envelope	envelope	NN
cord-342936-43u7afl3	190	21	glycans	glycan	NNS
cord-342936-43u7afl3	190	22	,	,	,
cord-342936-43u7afl3	190	23	and	and	CC
cord-342936-43u7afl3	190	24	subsequently	subsequently	RB
cord-342936-43u7afl3	190	25	presents	present	VBZ
cord-342936-43u7afl3	190	26	the	the	DT
cord-342936-43u7afl3	190	27	pathogen	pathogen	NN
cord-342936-43u7afl3	190	28	or	or	CC
cord-342936-43u7afl3	190	29	pathogen	pathogen	NN
cord-342936-43u7afl3	190	30	fragments	fragment	NNS
cord-342936-43u7afl3	190	31	to	to	TO
cord-342936-43u7afl3	190	32	appropriate	appropriate	VB
cord-342936-43u7afl3	190	33	T	T	NNP
cord-342936-43u7afl3	190	34	cells	cell	NNS
cord-342936-43u7afl3	190	35	74	74	CD
cord-342936-43u7afl3	190	36	.	.	.
cord-342936-43u7afl3	191	1	These	these	DT
cord-342936-43u7afl3	191	2	observations	observation	NNS
cord-342936-43u7afl3	191	3	are	be	VBP
cord-342936-43u7afl3	191	4	potentially	potentially	RB
cord-342936-43u7afl3	191	5	important	important	JJ
cord-342936-43u7afl3	191	6	from	from	IN
cord-342936-43u7afl3	191	7	a	a	DT
cord-342936-43u7afl3	191	8	microbicide	microbicide	JJ
cord-342936-43u7afl3	191	9	viewpoint	viewpoint	NN
cord-342936-43u7afl3	191	10	,	,	,
cord-342936-43u7afl3	191	11	as	as	IN
cord-342936-43u7afl3	191	12	microbicides	microbicide	NNS
cord-342936-43u7afl3	191	13	aim	aim	VBP
cord-342936-43u7afl3	191	14	to	to	TO
cord-342936-43u7afl3	191	15	prevent	prevent	VB
cord-342936-43u7afl3	191	16	virus	virus	NN
cord-342936-43u7afl3	191	17	infection	infection	NN
cord-342936-43u7afl3	191	18	that	that	WDT
cord-342936-43u7afl3	191	19	may	may	MD
cord-342936-43u7afl3	191	20	occur	occur	VB
cord-342936-43u7afl3	191	21	after	after	IN
cord-342936-43u7afl3	191	22	the	the	DT
cord-342936-43u7afl3	191	23	exposure	exposure	NN
cord-342936-43u7afl3	191	24	of	of	IN
cord-342936-43u7afl3	191	25	an	an	DT
cord-342936-43u7afl3	191	26	individual	individual	NN
cord-342936-43u7afl3	191	27	to	to	IN
cord-342936-43u7afl3	191	28	the	the	DT
cord-342936-43u7afl3	191	29	virus	virus	NN
cord-342936-43u7afl3	191	30	through	through	IN
cord-342936-43u7afl3	191	31	sexual	sexual	JJ
cord-342936-43u7afl3	191	32	intercourse	intercourse	NN
cord-342936-43u7afl3	191	33	.	.	.
cord-342936-43u7afl3	192	1	Indeed	indeed	RB
cord-342936-43u7afl3	192	2	,	,	,
cord-342936-43u7afl3	192	3	DC	DC	NNP
cord-342936-43u7afl3	192	4	-	-	HYPH
cord-342936-43u7afl3	192	5	SIGNmediated	signmediate	VBN
cord-342936-43u7afl3	192	6	virus	virus	NN
cord-342936-43u7afl3	192	7	capture	capture	NN
cord-342936-43u7afl3	192	8	and	and	CC
cord-342936-43u7afl3	192	9	transmission	transmission	NN
cord-342936-43u7afl3	192	10	to	to	IN
cord-342936-43u7afl3	192	11	T	t	NN
cord-342936-43u7afl3	192	12	cells	cell	NNS
cord-342936-43u7afl3	192	13	is	be	VBZ
cord-342936-43u7afl3	192	14	believed	believe	VBN
cord-342936-43u7afl3	192	15	to	to	TO
cord-342936-43u7afl3	192	16	be	be	VB
cord-342936-43u7afl3	192	17	among	among	IN
cord-342936-43u7afl3	192	18	the	the	DT
cord-342936-43u7afl3	192	19	first	first	JJ
cord-342936-43u7afl3	192	20	events	event	NNS
cord-342936-43u7afl3	192	21	that	that	WDT
cord-342936-43u7afl3	192	22	occur	occur	VBP
cord-342936-43u7afl3	192	23	during	during	IN
cord-342936-43u7afl3	192	24	the	the	DT
cord-342936-43u7afl3	192	25	viral	viral	JJ
cord-342936-43u7afl3	192	26	infection	infection	NN
cord-342936-43u7afl3	192	27	process	process	NN
cord-342936-43u7afl3	192	28	through	through	IN
cord-342936-43u7afl3	192	29	sexual	sexual	JJ
cord-342936-43u7afl3	192	30	contact	contact	NN
cord-342936-43u7afl3	192	31	75	75	CD
cord-342936-43u7afl3	192	32	,	,	,
cord-342936-43u7afl3	192	33	76	76	CD
cord-342936-43u7afl3	192	34	(	(	-LRB-
cord-342936-43u7afl3	192	35	BOX	BOX	NNP
cord-342936-43u7afl3	192	36	1	1	CD
cord-342936-43u7afl3	192	37	)	)	-RRB-
cord-342936-43u7afl3	192	38	.	.	.
cord-342936-43u7afl3	193	1	However	however	RB
cord-342936-43u7afl3	193	2	,	,	,
cord-342936-43u7afl3	193	3	its	-PRON-	PRP$
cord-342936-43u7afl3	193	4	exact	exact	JJ
cord-342936-43u7afl3	193	5	role	role	NN
cord-342936-43u7afl3	193	6	in	in	IN
cord-342936-43u7afl3	193	7	HIV	HIV	NNP
cord-342936-43u7afl3	193	8	transmission	transmission	NN
cord-342936-43u7afl3	193	9	remains	remain	VBZ
cord-342936-43u7afl3	193	10	controversial	controversial	JJ
cord-342936-43u7afl3	193	11	-Boggiano	-boggiano	NN
cord-342936-43u7afl3	194	1	et	et	NNP
cord-342936-43u7afl3	194	2	al	al	NNP
cord-342936-43u7afl3	194	3	.	.	.
cord-342936-43u7afl3	195	1	77	77	CD
cord-342936-43u7afl3	195	2	and	and	CC
cord-342936-43u7afl3	195	3	Wang	Wang	NNP
cord-342936-43u7afl3	195	4	et	et	NNP
cord-342936-43u7afl3	195	5	al	al	NNP
cord-342936-43u7afl3	195	6	.	.	.
cord-342936-43u7afl3	196	1	78	78	CD
cord-342936-43u7afl3	196	2	Agents	agent	NNS
cord-342936-43u7afl3	196	3	that	that	WDT
cord-342936-43u7afl3	196	4	efficiently	efficiently	RB
cord-342936-43u7afl3	196	5	prevent	prevent	VBP
cord-342936-43u7afl3	196	6	the	the	DT
cord-342936-43u7afl3	196	7	first	first	JJ
cord-342936-43u7afl3	196	8	steps	step	NNS
cord-342936-43u7afl3	196	9	of	of	IN
cord-342936-43u7afl3	196	10	virus	virus	NN
cord-342936-43u7afl3	196	11	propagation	propagation	NN
cord-342936-43u7afl3	196	12	may	may	MD
cord-342936-43u7afl3	196	13	qualify	qualify	VB
cord-342936-43u7afl3	196	14	as	as	IN
cord-342936-43u7afl3	196	15	promising	promising	JJ
cord-342936-43u7afl3	196	16	microbicidal	microbicidal	JJ
cord-342936-43u7afl3	196	17	agents	agent	NNS
cord-342936-43u7afl3	196	18	and	and	CC
cord-342936-43u7afl3	196	19	have	have	VBP
cord-342936-43u7afl3	196	20	the	the	DT
cord-342936-43u7afl3	196	21	potential	potential	NN
cord-342936-43u7afl3	196	22	to	to	TO
cord-342936-43u7afl3	196	23	prevent	prevent	VB
cord-342936-43u7afl3	196	24	persistent	persistent	JJ
cord-342936-43u7afl3	196	25	establishment	establishment	NN
cord-342936-43u7afl3	196	26	of	of	IN
cord-342936-43u7afl3	196	27	infection	infection	NN
cord-342936-43u7afl3	196	28	.	.	.
cord-342936-43u7afl3	197	1	The	the	DT
cord-342936-43u7afl3	197	2	observation	observation	NN
cord-342936-43u7afl3	197	3	that	that	IN
cord-342936-43u7afl3	197	4	CBAs	cba	NNS
cord-342936-43u7afl3	197	5	might	may	MD
cord-342936-43u7afl3	197	6	compete	compete	VB
cord-342936-43u7afl3	197	7	directly	directly	RB
cord-342936-43u7afl3	197	8	with	with	IN
cord-342936-43u7afl3	197	9	DC	DC	NNP
cord-342936-43u7afl3	197	10	-	-	HYPH
cord-342936-43u7afl3	197	11	SIGN	SIGN	NNP
cord-342936-43u7afl3	197	12	to	to	TO
cord-342936-43u7afl3	197	13	capture	capture	VB
cord-342936-43u7afl3	197	14	HIV	HIV	NNP
cord-342936-43u7afl3	197	15	deserves	deserve	VBZ
cord-342936-43u7afl3	197	16	further	further	JJ
cord-342936-43u7afl3	197	17	investigation	investigation	NN
cord-342936-43u7afl3	197	18	in	in	IN
cord-342936-43u7afl3	197	19	terms	term	NNS
cord-342936-43u7afl3	197	20	of	of	IN
cord-342936-43u7afl3	197	21	their	-PRON-	PRP$
cord-342936-43u7afl3	197	22	impact	impact	NN
cord-342936-43u7afl3	197	23	on	on	IN
cord-342936-43u7afl3	197	24	the	the	DT
cord-342936-43u7afl3	197	25	efficiency	efficiency	NN
cord-342936-43u7afl3	197	26	of	of	IN
cord-342936-43u7afl3	197	27	virus	virus	NN
cord-342936-43u7afl3	197	28	capture	capture	NN
cord-342936-43u7afl3	197	29	and	and	CC
cord-342936-43u7afl3	197	30	the	the	DT
cord-342936-43u7afl3	197	31	subsequent	subsequent	JJ
cord-342936-43u7afl3	197	32	transmission	transmission	NN
cord-342936-43u7afl3	197	33	of	of	IN
cord-342936-43u7afl3	197	34	the	the	DT
cord-342936-43u7afl3	197	35	virus	virus	NN
cord-342936-43u7afl3	197	36	to	to	IN
cord-342936-43u7afl3	197	37	T	t	NN
cord-342936-43u7afl3	197	38	cells	cell	NNS
cord-342936-43u7afl3	197	39	.	.	.
cord-342936-43u7afl3	198	1	Interestingly	interestingly	RB
cord-342936-43u7afl3	198	2	,	,	,
cord-342936-43u7afl3	198	3	it	-PRON-	PRP
cord-342936-43u7afl3	198	4	was	be	VBD
cord-342936-43u7afl3	198	5	recently	recently	RB
cord-342936-43u7afl3	198	6	reported	report	VBN
cord-342936-43u7afl3	198	7	that	that	IN
cord-342936-43u7afl3	198	8	langerin	langerin	NNP
cord-342936-43u7afl3	198	9	,	,	,
cord-342936-43u7afl3	198	10	a	a	DT
cord-342936-43u7afl3	198	11	C	c	NN
cord-342936-43u7afl3	198	12	-	-	HYPH
cord-342936-43u7afl3	198	13	type	type	NN
cord-342936-43u7afl3	198	14	lectin	lectin	NN
cord-342936-43u7afl3	198	15	that	that	WDT
cord-342936-43u7afl3	198	16	is	be	VBZ
cord-342936-43u7afl3	198	17	present	present	JJ
cord-342936-43u7afl3	198	18	on	on	IN
cord-342936-43u7afl3	198	19	epithelial	epithelial	JJ
cord-342936-43u7afl3	198	20	Langerhans	Langerhans	NNP
cord-342936-43u7afl3	198	21	cells	cell	NNS
cord-342936-43u7afl3	198	22	(	(	-LRB-
cord-342936-43u7afl3	198	23	LCs	LCs	NNP
cord-342936-43u7afl3	198	24	)	)	-RRB-
cord-342936-43u7afl3	198	25	,	,	,
cord-342936-43u7afl3	198	26	prevents	prevent	VBZ
cord-342936-43u7afl3	198	27	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	198	28	transmission	transmission	NN
cord-342936-43u7afl3	198	29	by	by	IN
cord-342936-43u7afl3	198	30	LCs	lc	NNS
cord-342936-43u7afl3	198	31	by	by	IN
cord-342936-43u7afl3	198	32	internalization	internalization	NN
cord-342936-43u7afl3	198	33	of	of	IN
cord-342936-43u7afl3	198	34	captured	capture	VBN
cord-342936-43u7afl3	198	35	HIV	HIV	NNP
cord-342936-43u7afl3	198	36	particles	particle	NNS
cord-342936-43u7afl3	198	37	and	and	CC
cord-342936-43u7afl3	198	38	subsequent	subsequent	JJ
cord-342936-43u7afl3	198	39	intracellular	intracellular	JJ
cord-342936-43u7afl3	198	40	degradation	degradation	NN
cord-342936-43u7afl3	198	41	79	79	CD
cord-342936-43u7afl3	198	42	.	.	.
cord-342936-43u7afl3	199	1	Although	although	IN
cord-342936-43u7afl3	199	2	such	such	JJ
cord-342936-43u7afl3	199	3	a	a	DT
cord-342936-43u7afl3	199	4	mechanism	mechanism	NN
cord-342936-43u7afl3	199	5	may	may	MD
cord-342936-43u7afl3	199	6	be	be	VB
cord-342936-43u7afl3	199	7	efficient	efficient	JJ
cord-342936-43u7afl3	199	8	for	for	IN
cord-342936-43u7afl3	199	9	a	a	DT
cord-342936-43u7afl3	199	10	first	first	JJ
cord-342936-43u7afl3	199	11	-	-	HYPH
cord-342936-43u7afl3	199	12	line	line	NN
cord-342936-43u7afl3	199	13	inactivation	inactivation	NN
cord-342936-43u7afl3	199	14	of	of	IN
cord-342936-43u7afl3	199	15	HIV	HIV	NNP
cord-342936-43u7afl3	199	16	,	,	,
cord-342936-43u7afl3	199	17	CBA	CBA	NNP
cord-342936-43u7afl3	199	18	-	-	HYPH
cord-342936-43u7afl3	199	19	exposed	expose	VBN
cord-342936-43u7afl3	199	20	HIV	HIV	NNP
cord-342936-43u7afl3	199	21	strains	strain	NNS
cord-342936-43u7afl3	199	22	may	may	MD
cord-342936-43u7afl3	199	23	decrease	decrease	VB
cord-342936-43u7afl3	199	24	the	the	DT
cord-342936-43u7afl3	199	25	efficiency	efficiency	NN
cord-342936-43u7afl3	199	26	of	of	IN
cord-342936-43u7afl3	199	27	LCs	LCs	NNP
cord-342936-43u7afl3	199	28	to	to	TO
cord-342936-43u7afl3	199	29	eliminate	eliminate	VB
cord-342936-43u7afl3	199	30	HIV	HIV	NNP
cord-342936-43u7afl3	199	31	,	,	,
cord-342936-43u7afl3	199	32	but	but	CC
cord-342936-43u7afl3	199	33	at	at	IN
cord-342936-43u7afl3	199	34	the	the	DT
cord-342936-43u7afl3	199	35	same	same	JJ
cord-342936-43u7afl3	199	36	time	time	NN
cord-342936-43u7afl3	199	37	may	may	MD
cord-342936-43u7afl3	199	38	compromise	compromise	VB
cord-342936-43u7afl3	199	39	the	the	DT
cord-342936-43u7afl3	199	40	ability	ability	NN
cord-342936-43u7afl3	199	41	of	of	IN
cord-342936-43u7afl3	199	42	the	the	DT
cord-342936-43u7afl3	199	43	virus	virus	NN
cord-342936-43u7afl3	199	44	to	to	TO
cord-342936-43u7afl3	199	45	be	be	VB
cord-342936-43u7afl3	199	46	efficiently	efficiently	RB
cord-342936-43u7afl3	199	47	transmitted	transmit	VBN
cord-342936-43u7afl3	199	48	by	by	IN
cord-342936-43u7afl3	199	49	DCs	DCs	NNP
cord-342936-43u7afl3	199	50	.	.	.
cord-342936-43u7afl3	200	1	The	the	DT
cord-342936-43u7afl3	200	2	interactions	interaction	NNS
cord-342936-43u7afl3	200	3	of	of	IN
cord-342936-43u7afl3	200	4	several	several	JJ
cord-342936-43u7afl3	200	5	CBAs	cba	NNS
cord-342936-43u7afl3	200	6	have	have	VBP
cord-342936-43u7afl3	200	7	been	be	VBN
cord-342936-43u7afl3	200	8	extensively	extensively	RB
cord-342936-43u7afl3	200	9	investigated	investigate	VBN
cord-342936-43u7afl3	200	10	,	,	,
cord-342936-43u7afl3	200	11	including	include	VBG
cord-342936-43u7afl3	200	12	:	:	:
cord-342936-43u7afl3	200	13	the	the	DT
cord-342936-43u7afl3	200	14	prokaryotic	prokaryotic	JJ
cord-342936-43u7afl3	200	15	CV	CV	NNP
cord-342936-43u7afl3	200	16	-	-	HYPH
cord-342936-43u7afl3	200	17	N	N	NNP
cord-342936-43u7afl3	200	18	and	and	CC
cord-342936-43u7afl3	200	19	actinohivin	actinohivin	NNP
cord-342936-43u7afl3	200	20	;	;	:
cord-342936-43u7afl3	200	21	a	a	DT
cord-342936-43u7afl3	200	22	variety	variety	NN
cord-342936-43u7afl3	200	23	of	of	IN
cord-342936-43u7afl3	200	24	plant	plant	NN
cord-342936-43u7afl3	200	25	lectins	lectin	NNS
cord-342936-43u7afl3	200	26	,	,	,
cord-342936-43u7afl3	200	27	including	include	VBG
cord-342936-43u7afl3	200	28	Hippeastrum	Hippeastrum	NNP
cord-342936-43u7afl3	200	29	hybrid	hybrid	NN
cord-342936-43u7afl3	200	30	agglutinin	agglutinin	NNS
cord-342936-43u7afl3	200	31	(	(	-LRB-
cord-342936-43u7afl3	200	32	HHA	HHA	NNP
cord-342936-43u7afl3	200	33	)	)	-RRB-
cord-342936-43u7afl3	200	34	and	and	CC
cord-342936-43u7afl3	200	35	UDA	UDA	NNP
cord-342936-43u7afl3	200	36	;	;	:
cord-342936-43u7afl3	200	37	the	the	DT
cord-342936-43u7afl3	200	38	non	non	JJ
cord-342936-43u7afl3	200	39	-	-	JJ
cord-342936-43u7afl3	200	40	peptidic	peptidic	JJ
cord-342936-43u7afl3	200	41	low	low	JJ
cord-342936-43u7afl3	200	42	-	-	HYPH
cord-342936-43u7afl3	200	43	molecular	molecular	JJ
cord-342936-43u7afl3	200	44	-	-	HYPH
cord-342936-43u7afl3	200	45	weight	weight	NN
cord-342936-43u7afl3	200	46	antibiotic	antibiotic	NN
cord-342936-43u7afl3	200	47	PRM	PRM	NNP
cord-342936-43u7afl3	200	48	-	-	HYPH
cord-342936-43u7afl3	200	49	A	A	NNP
cord-342936-43u7afl3	200	50	;	;	,
cord-342936-43u7afl3	200	51	and	and	CC
cord-342936-43u7afl3	200	52	the	the	DT
cord-342936-43u7afl3	200	53	monoclonal	monoclonal	JJ
cord-342936-43u7afl3	200	54	antibody	antibody	NN
cord-342936-43u7afl3	200	55	2G12	2g12	CD
cord-342936-43u7afl3	200	56	with	with	IN
cord-342936-43u7afl3	200	57	the	the	DT
cord-342936-43u7afl3	200	58	HIV	HIV	NNP
cord-342936-43u7afl3	200	59	-	-	HYPH
cord-342936-43u7afl3	200	60	envelope	envelope	NN
cord-342936-43u7afl3	200	61	gp120	gp120	NNP
cord-342936-43u7afl3	200	62	and/or	and/or	CC
cord-342936-43u7afl3	200	63	several	several	JJ
cord-342936-43u7afl3	200	64	glycan	glycan	NN
cord-342936-43u7afl3	200	65	structures	structure	NNS
cord-342936-43u7afl3	200	66	.	.	.
cord-342936-43u7afl3	201	1	Interestingly	interestingly	RB
cord-342936-43u7afl3	201	2	,	,	,
cord-342936-43u7afl3	201	3	deletion	deletion	NN
cord-342936-43u7afl3	201	4	of	of	IN
cord-342936-43u7afl3	201	5	the	the	DT
cord-342936-43u7afl3	201	6	N	N	NNP
cord-342936-43u7afl3	201	7	-	-	HYPH
cord-342936-43u7afl3	201	8	glycans	glycan	NNS
cord-342936-43u7afl3	201	9	at	at	IN
cord-342936-43u7afl3	201	10	amino	amino	NN
cord-342936-43u7afl3	201	11	-	-	HYPH
cord-342936-43u7afl3	201	12	acid	acid	NN
cord-342936-43u7afl3	201	13	positions	position	NNS
cord-342936-43u7afl3	201	14	295	295	CD
cord-342936-43u7afl3	201	15	,	,	,
cord-342936-43u7afl3	201	16	392	392	CD
cord-342936-43u7afl3	201	17	and/or	and/or	CC
cord-342936-43u7afl3	201	18	406	406	CD
cord-342936-43u7afl3	201	19	rendered	render	VBD
cord-342936-43u7afl3	201	20	the	the	DT
cord-342936-43u7afl3	201	21	2G12	2g12	CD
cord-342936-43u7afl3	201	22	monoclonal	monoclonal	JJ
cord-342936-43u7afl3	201	23	antibody	antibody	NN
cord-342936-43u7afl3	201	24	completely	completely	RB
cord-342936-43u7afl3	201	25	incapable	incapable	JJ
cord-342936-43u7afl3	201	26	of	of	IN
cord-342936-43u7afl3	201	27	efficiently	efficiently	RB
cord-342936-43u7afl3	201	28	neutralizing	neutralize	VBG
cord-342936-43u7afl3	201	29	the	the	DT
cord-342936-43u7afl3	201	30	virus	virus	NN
cord-342936-43u7afl3	201	31	particle	particle	NN
cord-342936-43u7afl3	201	32	54	54	CD
cord-342936-43u7afl3	201	33	.	.	.
cord-342936-43u7afl3	202	1	The	the	DT
cord-342936-43u7afl3	202	2	asparagines	asparagine	NNS
cord-342936-43u7afl3	202	3	at	at	IN
cord-342936-43u7afl3	202	4	positions	position	NNS
cord-342936-43u7afl3	202	5	295	295	CD
cord-342936-43u7afl3	202	6	,	,	,
cord-342936-43u7afl3	202	7	332	332	CD
cord-342936-43u7afl3	202	8	and	and	CC
cord-342936-43u7afl3	202	9	392	392	CD
cord-342936-43u7afl3	202	10	were	be	VBD
cord-342936-43u7afl3	202	11	previously	previously	RB
cord-342936-43u7afl3	202	12	shown	show	VBN
cord-342936-43u7afl3	202	13	in	in	IN
cord-342936-43u7afl3	202	14	crystallographic	crystallographic	JJ
cord-342936-43u7afl3	202	15	gp120	gp120	CD
cord-342936-43u7afl3	202	16	-	-	HYPH
cord-342936-43u7afl3	202	17	2G12	2g12	CD
cord-342936-43u7afl3	202	18	complexes	complex	NNS
cord-342936-43u7afl3	202	19	to	to	TO
cord-342936-43u7afl3	202	20	be	be	VB
cord-342936-43u7afl3	202	21	indispensable	indispensable	JJ
cord-342936-43u7afl3	202	22	for	for	IN
cord-342936-43u7afl3	202	23	an	an	DT
cord-342936-43u7afl3	202	24	efficient	efficient	JJ
cord-342936-43u7afl3	202	25	interaction	interaction	NN
cord-342936-43u7afl3	202	26	with	with	IN
cord-342936-43u7afl3	202	27	the	the	DT
cord-342936-43u7afl3	202	28	2G12	2g12	CD
cord-342936-43u7afl3	202	29	monoclonal	monoclonal	JJ
cord-342936-43u7afl3	202	30	antibody	antibody	NN
cord-342936-43u7afl3	202	31	80	80	CD
cord-342936-43u7afl3	202	32	.	.	.
cord-342936-43u7afl3	203	1	The	the	DT
cord-342936-43u7afl3	203	2	interaction	interaction	NN
cord-342936-43u7afl3	203	3	of	of	IN
cord-342936-43u7afl3	203	4	the	the	DT
cord-342936-43u7afl3	203	5	monoclonal	monoclonal	JJ
cord-342936-43u7afl3	203	6	antibody	antibody	NN
cord-342936-43u7afl3	203	7	2G12	2g12	CD
cord-342936-43u7afl3	203	8	with	with	IN
cord-342936-43u7afl3	203	9	the	the	DT
cord-342936-43u7afl3	203	10	glycans	glycan	NNS
cord-342936-43u7afl3	203	11	on	on	IN
cord-342936-43u7afl3	203	12	a	a	DT
cord-342936-43u7afl3	203	13	well	well	RB
cord-342936-43u7afl3	203	14	-	-	HYPH
cord-342936-43u7afl3	203	15	defined	define	VBN
cord-342936-43u7afl3	203	16	gp120	gp120	NNP
cord-342936-43u7afl3	203	17	epitope	epitope	NN
cord-342936-43u7afl3	203	18	has	have	VBZ
cord-342936-43u7afl3	203	19	also	also	RB
cord-342936-43u7afl3	203	20	been	be	VBN
cord-342936-43u7afl3	203	21	revealed	reveal	VBN
cord-342936-43u7afl3	203	22	in	in	IN
cord-342936-43u7afl3	203	23	several	several	JJ
cord-342936-43u7afl3	203	24	studies	study	NNS
cord-342936-43u7afl3	203	25	49	49	CD
cord-342936-43u7afl3	203	26	,	,	,
cord-342936-43u7afl3	203	27	51	51	CD
cord-342936-43u7afl3	203	28	,	,	,
cord-342936-43u7afl3	203	29	52	52	CD
cord-342936-43u7afl3	203	30	.	.	.
cord-342936-43u7afl3	204	1	Alteration	alteration	NN
cord-342936-43u7afl3	204	2	of	of	IN
cord-342936-43u7afl3	204	3	the	the	DT
cord-342936-43u7afl3	204	4	glycosylation	glycosylation	NN
cord-342936-43u7afl3	204	5	pattern	pattern	NN
cord-342936-43u7afl3	204	6	of	of	IN
cord-342936-43u7afl3	204	7	HIV	HIV	NNP
cord-342936-43u7afl3	204	8	gp120	gp120	NNP
cord-342936-43u7afl3	204	9	in	in	IN
cord-342936-43u7afl3	204	10	the	the	DT
cord-342936-43u7afl3	204	11	ER	ER	NNP
cord-342936-43u7afl3	204	12	by	by	IN
cord-342936-43u7afl3	204	13	inhibiting	inhibit	VBG
cord-342936-43u7afl3	204	14	the	the	DT
cord-342936-43u7afl3	204	15	glycosidases	glycosidase	NNS
cord-342936-43u7afl3	204	16	I	I	NNP
cord-342936-43u7afl3	204	17	and	and	CC
cord-342936-43u7afl3	204	18	II	II	NNP
cord-342936-43u7afl3	204	19	prevents	prevent	VBZ
cord-342936-43u7afl3	204	20	proper	proper	JJ
cord-342936-43u7afl3	204	21	folding	folding	NN
cord-342936-43u7afl3	204	22	of	of	IN
cord-342936-43u7afl3	204	23	gp120	gp120	NNP
cord-342936-43u7afl3	204	24	.	.	.
cord-342936-43u7afl3	205	1	Consequently	consequently	RB
cord-342936-43u7afl3	205	2	,	,	,
cord-342936-43u7afl3	205	3	the	the	DT
cord-342936-43u7afl3	205	4	interaction	interaction	NN
cord-342936-43u7afl3	205	5	of	of	IN
cord-342936-43u7afl3	205	6	gp120	gp120	NNP
cord-342936-43u7afl3	205	7	with	with	IN
cord-342936-43u7afl3	205	8	the	the	DT
cord-342936-43u7afl3	205	9	ER	ER	NNP
cord-342936-43u7afl3	205	10	lectin	lectin	NN
cord-342936-43u7afl3	205	11	calnexin	calnexin	NN
cord-342936-43u7afl3	205	12	is	be	VBZ
cord-342936-43u7afl3	205	13	inhibited	inhibit	VBN
cord-342936-43u7afl3	205	14	81	81	CD
cord-342936-43u7afl3	205	15	and	and	CC
cord-342936-43u7afl3	205	16	,	,	,
cord-342936-43u7afl3	205	17	as	as	IN
cord-342936-43u7afl3	205	18	a	a	DT
cord-342936-43u7afl3	205	19	result	result	NN
cord-342936-43u7afl3	205	20	,	,	,
cord-342936-43u7afl3	205	21	fewer	few	JJR
cord-342936-43u7afl3	205	22	infectious	infectious	JJ
cord-342936-43u7afl3	205	23	virus	virus	NN
cord-342936-43u7afl3	205	24	particles	particle	NNS
cord-342936-43u7afl3	205	25	are	be	VBP
cord-342936-43u7afl3	205	26	released	release	VBN
cord-342936-43u7afl3	205	27	by	by	IN
cord-342936-43u7afl3	205	28	the	the	DT
cord-342936-43u7afl3	205	29	drug	drug	NN
cord-342936-43u7afl3	205	30	-	-	HYPH
cord-342936-43u7afl3	205	31	treated	treat	VBN
cord-342936-43u7afl3	205	32	cells	cell	NNS
cord-342936-43u7afl3	205	33	.	.	.
cord-342936-43u7afl3	206	1	In	in	IN
cord-342936-43u7afl3	206	2	addition	addition	NN
cord-342936-43u7afl3	206	3	,	,	,
cord-342936-43u7afl3	206	4	virus	virus	NN
cord-342936-43u7afl3	206	5	particles	particle	NNS
cord-342936-43u7afl3	206	6	from	from	IN
cord-342936-43u7afl3	206	7	which	which	WDT
cord-342936-43u7afl3	206	8	the	the	DT
cord-342936-43u7afl3	206	9	glycans	glycan	NNS
cord-342936-43u7afl3	206	10	had	have	VBD
cord-342936-43u7afl3	206	11	been	be	VBN
cord-342936-43u7afl3	206	12	stripped	strip	VBN
cord-342936-43u7afl3	206	13	became	become	VBD
cord-342936-43u7afl3	206	14	markedly	markedly	RB
cord-342936-43u7afl3	206	15	less	less	RBR
cord-342936-43u7afl3	206	16	infectious	infectious	JJ
cord-342936-43u7afl3	206	17	.	.	.
cord-342936-43u7afl3	207	1	Interestingly	interestingly	RB
cord-342936-43u7afl3	207	2	,	,	,
cord-342936-43u7afl3	207	3	combining	combine	VBG
cord-342936-43u7afl3	207	4	CBAs	cba	NNS
cord-342936-43u7afl3	207	5	with	with	IN
cord-342936-43u7afl3	207	6	the	the	DT
cord-342936-43u7afl3	207	7	mannosidase	mannosidase	NN
cord-342936-43u7afl3	207	8	inhibitor	inhibitor	NN
cord-342936-43u7afl3	207	9	1-deoxymannojirimycin	1-deoxymannojirimycin	CD
cord-342936-43u7afl3	207	10	(	(	-LRB-
cord-342936-43u7afl3	207	11	DMJ	DMJ	NNP
cord-342936-43u7afl3	207	12	)	)	-RRB-
cord-342936-43u7afl3	207	13	led	lead	VBD
cord-342936-43u7afl3	207	14	to	to	IN
cord-342936-43u7afl3	207	15	the	the	DT
cord-342936-43u7afl3	207	16	expression	expression	NN
cord-342936-43u7afl3	207	17	of	of	IN
cord-342936-43u7afl3	207	18	synergistic	synergistic	JJ
cord-342936-43u7afl3	207	19	antiviral	antiviral	JJ
cord-342936-43u7afl3	207	20	activity	activity	NN
cord-342936-43u7afl3	207	21	82	82	CD
cord-342936-43u7afl3	207	22	.	.	.
cord-342936-43u7afl3	208	1	Exposure	exposure	NN
cord-342936-43u7afl3	208	2	of	of	IN
cord-342936-43u7afl3	208	3	glycandeleted	glycandeleted	JJ
cord-342936-43u7afl3	208	4	mutant	mutant	JJ
cord-342936-43u7afl3	208	5	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	208	6	strains	strain	NNS
cord-342936-43u7afl3	208	7	to	to	IN
cord-342936-43u7afl3	208	8	DMJ	DMJ	NNP
cord-342936-43u7afl3	208	9	results	result	NNS
cord-342936-43u7afl3	208	10	in	in	IN
cord-342936-43u7afl3	208	11	an	an	DT
cord-342936-43u7afl3	208	12	enhanced	enhanced	JJ
cord-342936-43u7afl3	208	13	suppression	suppression	NN
cord-342936-43u7afl3	208	14	of	of	IN
cord-342936-43u7afl3	208	15	mutant	mutant	JJ
cord-342936-43u7afl3	208	16	virus	virus	NN
cord-342936-43u7afl3	208	17	-	-	HYPH
cord-342936-43u7afl3	208	18	induced	induce	VBN
cord-342936-43u7afl3	208	19	cytopathicity	cytopathicity	NN
cord-342936-43u7afl3	208	20	in	in	IN
cord-342936-43u7afl3	208	21	cell	cell	NN
cord-342936-43u7afl3	208	22	culture	culture	NN
cord-342936-43u7afl3	208	23	82	82	CD
cord-342936-43u7afl3	208	24	.	.	.
cord-342936-43u7afl3	209	1	Therefore	therefore	RB
cord-342936-43u7afl3	209	2	,	,	,
cord-342936-43u7afl3	209	3	the	the	DT
cord-342936-43u7afl3	209	4	presence	presence	NN
cord-342936-43u7afl3	209	5	of	of	IN
cord-342936-43u7afl3	209	6	an	an	DT
cord-342936-43u7afl3	209	7	intact	intact	JJ
cord-342936-43u7afl3	209	8	glycan	glycan	NN
cord-342936-43u7afl3	209	9	shield	shield	NN
cord-342936-43u7afl3	209	10	on	on	IN
cord-342936-43u7afl3	209	11	gp120	gp120	NNP
cord-342936-43u7afl3	209	12	has	have	VBZ
cord-342936-43u7afl3	209	13	also	also	RB
cord-342936-43u7afl3	209	14	been	be	VBN
cord-342936-43u7afl3	209	15	proven	prove	VBN
cord-342936-43u7afl3	209	16	to	to	TO
cord-342936-43u7afl3	209	17	be	be	VB
cord-342936-43u7afl3	209	18	indispensable	indispensable	JJ
cord-342936-43u7afl3	209	19	for	for	IN
cord-342936-43u7afl3	209	20	optimal	optimal	JJ
cord-342936-43u7afl3	209	21	infectivity	infectivity	NN
cord-342936-43u7afl3	209	22	and	and	CC
cord-342936-43u7afl3	209	23	for	for	IN
cord-342936-43u7afl3	209	24	an	an	DT
cord-342936-43u7afl3	209	25	efficient	efficient	JJ
cord-342936-43u7afl3	209	26	interaction	interaction	NN
cord-342936-43u7afl3	209	27	of	of	IN
cord-342936-43u7afl3	209	28	HIV	HIV	NNP
cord-342936-43u7afl3	209	29	with	with	IN
cord-342936-43u7afl3	209	30	its	-PRON-	PRP$
cord-342936-43u7afl3	209	31	target	target	NN
cord-342936-43u7afl3	209	32	cells	cell	NNS
cord-342936-43u7afl3	209	33	.	.	.
cord-342936-43u7afl3	210	1	Studies	study	NNS
cord-342936-43u7afl3	210	2	determining	determine	VBG
cord-342936-43u7afl3	210	3	the	the	DT
cord-342936-43u7afl3	210	4	direct	direct	JJ
cord-342936-43u7afl3	210	5	interaction	interaction	NN
cord-342936-43u7afl3	210	6	of	of	IN
cord-342936-43u7afl3	210	7	CBAs	cba	NNS
cord-342936-43u7afl3	210	8	with	with	IN
cord-342936-43u7afl3	210	9	fixed	fix	VBN
cord-342936-43u7afl3	210	10	gp120	gp120	IN
cord-342936-43u7afl3	210	11	molecules	molecule	NNS
cord-342936-43u7afl3	210	12	have	have	VBP
cord-342936-43u7afl3	210	13	revealed	reveal	VBN
cord-342936-43u7afl3	210	14	the	the	DT
cord-342936-43u7afl3	210	15	strong	strong	JJ
cord-342936-43u7afl3	210	16	binding	bind	VBG
cord-342936-43u7afl3	210	17	affinity	affinity	NN
cord-342936-43u7afl3	210	18	of	of	IN
cord-342936-43u7afl3	210	19	CV	CV	NNP
cord-342936-43u7afl3	210	20	-	-	HYPH
cord-342936-43u7afl3	210	21	N	N	NNP
cord-342936-43u7afl3	210	22	,	,	,
cord-342936-43u7afl3	210	23	HHA	HHA	NNP
cord-342936-43u7afl3	210	24	,	,	,
cord-342936-43u7afl3	210	25	PRM	PRM	NNP
cord-342936-43u7afl3	210	26	-	-	HYPH
cord-342936-43u7afl3	210	27	A	A	NNP
cord-342936-43u7afl3	210	28	and	and	CC
cord-342936-43u7afl3	210	29	actinohivin	actinohivin	NN
cord-342936-43u7afl3	210	30	with	with	IN
cord-342936-43u7afl3	210	31	gp120	gp120	NNP
cord-342936-43u7afl3	210	32	.	.	.
cord-342936-43u7afl3	211	1	However	however	RB
cord-342936-43u7afl3	211	2	,	,	,
cord-342936-43u7afl3	211	3	for	for	IN
cord-342936-43u7afl3	211	4	certain	certain	JJ
cord-342936-43u7afl3	211	5	CBAs	cba	NNS
cord-342936-43u7afl3	211	6	(	(	-LRB-
cord-342936-43u7afl3	211	7	such	such	JJ
cord-342936-43u7afl3	211	8	as	as	IN
cord-342936-43u7afl3	211	9	CV	CV	NNP
cord-342936-43u7afl3	211	10	-	-	HYPH
cord-342936-43u7afl3	211	11	N	N	NNP
cord-342936-43u7afl3	211	12	and	and	CC
cord-342936-43u7afl3	211	13	HHA	HHA	NNP
cord-342936-43u7afl3	211	14	)	)	-RRB-
cord-342936-43u7afl3	211	15	,	,	,
cord-342936-43u7afl3	211	16	a	a	DT
cord-342936-43u7afl3	211	17	low	low	JJ
cord-342936-43u7afl3	211	18	dissociation	dissociation	NN
cord-342936-43u7afl3	211	19	rate	rate	NN
cord-342936-43u7afl3	211	20	was	be	VBD
cord-342936-43u7afl3	211	21	observed	observe	VBN
cord-342936-43u7afl3	211	22	22	22	CD
cord-342936-43u7afl3	211	23	,	,	,
cord-342936-43u7afl3	211	24	60	60	CD
cord-342936-43u7afl3	211	25	.	.	.
cord-342936-43u7afl3	212	1	These	these	DT
cord-342936-43u7afl3	212	2	results	result	NNS
cord-342936-43u7afl3	212	3	indicate	indicate	VBP
cord-342936-43u7afl3	212	4	that	that	IN
cord-342936-43u7afl3	212	5	some	some	DT
cord-342936-43u7afl3	212	6	of	of	IN
cord-342936-43u7afl3	212	7	the	the	DT
cord-342936-43u7afl3	212	8	CBAs	cba	NNS
cord-342936-43u7afl3	212	9	exert	exert	VBP
cord-342936-43u7afl3	212	10	a	a	DT
cord-342936-43u7afl3	212	11	strong	strong	JJ
cord-342936-43u7afl3	212	12	and	and	CC
cord-342936-43u7afl3	212	13	virtually	virtually	RB
cord-342936-43u7afl3	212	14	irreversible	irreversible	JJ
cord-342936-43u7afl3	212	15	binding	binding	NN
cord-342936-43u7afl3	212	16	to	to	IN
cord-342936-43u7afl3	212	17	gp120	gp120	NNP
cord-342936-43u7afl3	212	18	.	.	.
cord-342936-43u7afl3	213	1	This	this	DT
cord-342936-43u7afl3	213	2	is	be	VBZ
cord-342936-43u7afl3	213	3	in	in	IN
cord-342936-43u7afl3	213	4	agreement	agreement	NN
cord-342936-43u7afl3	213	5	with	with	IN
cord-342936-43u7afl3	213	6	cellular	cellular	JJ
cord-342936-43u7afl3	213	7	experiments	experiment	NNS
cord-342936-43u7afl3	213	8	,	,	,
cord-342936-43u7afl3	213	9	which	which	WDT
cord-342936-43u7afl3	213	10	show	show	VBP
cord-342936-43u7afl3	213	11	that	that	IN
cord-342936-43u7afl3	213	12	a	a	DT
cord-342936-43u7afl3	213	13	short	short	JJ
cord-342936-43u7afl3	213	14	pre	pre	NN
cord-342936-43u7afl3	213	15	-	-	NN
cord-342936-43u7afl3	213	16	incubation	incubation	NN
cord-342936-43u7afl3	213	17	of	of	IN
cord-342936-43u7afl3	213	18	cell	cell	NN
cord-342936-43u7afl3	213	19	-	-	HYPH
cord-342936-43u7afl3	213	20	free	free	JJ
cord-342936-43u7afl3	213	21	virus	virus	NN
cord-342936-43u7afl3	213	22	particles	particle	NNS
cord-342936-43u7afl3	213	23	with	with	IN
cord-342936-43u7afl3	213	24	CBAs	cba	NNS
cord-342936-43u7afl3	213	25	before	before	IN
cord-342936-43u7afl3	213	26	infection	infection	NN
cord-342936-43u7afl3	213	27	of	of	IN
cord-342936-43u7afl3	213	28	T	t	NN
cord-342936-43u7afl3	213	29	cells	cell	NNS
cord-342936-43u7afl3	213	30	markedly	markedly	RB
cord-342936-43u7afl3	213	31	increases	increase	VBZ
cord-342936-43u7afl3	213	32	the	the	DT
cord-342936-43u7afl3	213	33	antiviral	antiviral	JJ
cord-342936-43u7afl3	213	34	activity	activity	NN
cord-342936-43u7afl3	213	35	of	of	IN
cord-342936-43u7afl3	213	36	the	the	DT
cord-342936-43u7afl3	213	37	CBAs	cba	NNS
cord-342936-43u7afl3	213	38	18	18	CD
cord-342936-43u7afl3	213	39	,	,	,
cord-342936-43u7afl3	213	40	40	40	CD
cord-342936-43u7afl3	213	41	.	.	.
cord-342936-43u7afl3	214	1	The	the	DT
cord-342936-43u7afl3	214	2	binding	binding	NN
cord-342936-43u7afl3	214	3	of	of	IN
cord-342936-43u7afl3	214	4	the	the	DT
cord-342936-43u7afl3	214	5	CBA	CBA	NNP
cord-342936-43u7afl3	214	6	to	to	IN
cord-342936-43u7afl3	214	7	gp120	gp120	NNP
cord-342936-43u7afl3	214	8	does	do	VBZ
cord-342936-43u7afl3	214	9	not	not	RB
cord-342936-43u7afl3	214	10	prevent	prevent	VB
cord-342936-43u7afl3	214	11	the	the	DT
cord-342936-43u7afl3	214	12	initial	initial	JJ
cord-342936-43u7afl3	214	13	virus	virus	NN
cord-342936-43u7afl3	214	14	-	-	HYPH
cord-342936-43u7afl3	214	15	cell	cell	NN
cord-342936-43u7afl3	214	16	interaction	interaction	NN
cord-342936-43u7afl3	214	17	.	.	.
cord-342936-43u7afl3	215	1	Indeed	indeed	RB
cord-342936-43u7afl3	215	2	,	,	,
cord-342936-43u7afl3	215	3	it	-PRON-	PRP
cord-342936-43u7afl3	215	4	was	be	VBD
cord-342936-43u7afl3	215	5	found	find	VBN
cord-342936-43u7afl3	215	6	that	that	IN
cord-342936-43u7afl3	215	7	,	,	,
cord-342936-43u7afl3	215	8	in	in	IN
cord-342936-43u7afl3	215	9	the	the	DT
cord-342936-43u7afl3	215	10	presence	presence	NN
cord-342936-43u7afl3	215	11	of	of	IN
cord-342936-43u7afl3	215	12	CBAs	cba	NNS
cord-342936-43u7afl3	215	13	,	,	,
cord-342936-43u7afl3	215	14	the	the	DT
cord-342936-43u7afl3	215	15	virus	virus	NN
cord-342936-43u7afl3	215	16	could	could	MD
cord-342936-43u7afl3	215	17	still	still	RB
cord-342936-43u7afl3	215	18	efficiently	efficiently	RB
cord-342936-43u7afl3	215	19	bind	bind	VB
cord-342936-43u7afl3	215	20	CD4	CD4	NNP
cord-342936-43u7afl3	215	21	+	+	CC
cord-342936-43u7afl3	215	22	T	t	NN
cord-342936-43u7afl3	215	23	cells	cell	NNS
cord-342936-43u7afl3	215	24	38	38	CD
cord-342936-43u7afl3	215	25	.	.	.
cord-342936-43u7afl3	216	1	However	however	RB
cord-342936-43u7afl3	216	2	,	,	,
cord-342936-43u7afl3	216	3	one	one	CD
cord-342936-43u7afl3	216	4	of	of	IN
cord-342936-43u7afl3	216	5	the	the	DT
cord-342936-43u7afl3	216	6	next	next	JJ
cord-342936-43u7afl3	216	7	steps	step	NNS
cord-342936-43u7afl3	216	8	during	during	IN
cord-342936-43u7afl3	216	9	the	the	DT
cord-342936-43u7afl3	216	10	entry	entry	NN
cord-342936-43u7afl3	216	11	process	process	NN
cord-342936-43u7afl3	216	12	(	(	-LRB-
cord-342936-43u7afl3	216	13	which	which	WDT
cord-342936-43u7afl3	216	14	is	be	VBZ
cord-342936-43u7afl3	216	15	binding	bind	VBG
cord-342936-43u7afl3	216	16	to	to	IN
cord-342936-43u7afl3	216	17	the	the	DT
cord-342936-43u7afl3	216	18	co	co	JJ
cord-342936-43u7afl3	216	19	-	-	JJ
cord-342936-43u7afl3	216	20	receptor(s	receptor(s	NNP
cord-342936-43u7afl3	216	21	)	)	-RRB-
cord-342936-43u7afl3	216	22	and/or	and/or	CC
cord-342936-43u7afl3	216	23	the	the	DT
cord-342936-43u7afl3	216	24	subsequent	subsequent	JJ
cord-342936-43u7afl3	216	25	exposure	exposure	NN
cord-342936-43u7afl3	216	26	of	of	IN
cord-342936-43u7afl3	216	27	gp41	gp41	NNP
cord-342936-43u7afl3	216	28	to	to	IN
cord-342936-43u7afl3	216	29	the	the	DT
cord-342936-43u7afl3	216	30	target	target	NN
cord-342936-43u7afl3	216	31	-	-	HYPH
cord-342936-43u7afl3	216	32	cell	cell	NN
cord-342936-43u7afl3	216	33	membrane	membrane	NN
cord-342936-43u7afl3	216	34	)	)	-RRB-
cord-342936-43u7afl3	216	35	becomes	become	VBZ
cord-342936-43u7afl3	216	36	blocked	block	VBN
cord-342936-43u7afl3	216	37	in	in	IN
cord-342936-43u7afl3	216	38	the	the	DT
cord-342936-43u7afl3	216	39	presence	presence	NN
cord-342936-43u7afl3	216	40	of	of	IN
cord-342936-43u7afl3	216	41	the	the	DT
cord-342936-43u7afl3	216	42	CBA	CBA	NNP
cord-342936-43u7afl3	216	43	.	.	.
cord-342936-43u7afl3	217	1	The	the	DT
cord-342936-43u7afl3	217	2	exact	exact	JJ
cord-342936-43u7afl3	217	3	molecular	molecular	JJ
cord-342936-43u7afl3	217	4	mechanism	mechanism	NN
cord-342936-43u7afl3	217	5	of	of	IN
cord-342936-43u7afl3	217	6	the	the	DT
cord-342936-43u7afl3	217	7	blockade	blockade	NN
cord-342936-43u7afl3	217	8	of	of	IN
cord-342936-43u7afl3	217	9	virus	virus	NN
cord-342936-43u7afl3	217	10	entry	entry	NN
cord-342936-43u7afl3	217	11	and/or	and/or	CC
cord-342936-43u7afl3	217	12	fusion	fusion	NN
cord-342936-43u7afl3	217	13	has	have	VBZ
cord-342936-43u7afl3	217	14	not	not	RB
cord-342936-43u7afl3	217	15	yet	yet	RB
cord-342936-43u7afl3	217	16	been	be	VBN
cord-342936-43u7afl3	217	17	determined	determine	VBN
cord-342936-43u7afl3	217	18	.	.	.
cord-342936-43u7afl3	218	1	However	however	RB
cord-342936-43u7afl3	218	2	,	,	,
cord-342936-43u7afl3	218	3	it	-PRON-	PRP
cord-342936-43u7afl3	218	4	can	can	MD
cord-342936-43u7afl3	218	5	be	be	VB
cord-342936-43u7afl3	218	6	assumed	assume	VBN
cord-342936-43u7afl3	218	7	that	that	IN
cord-342936-43u7afl3	218	8	the	the	DT
cord-342936-43u7afl3	218	9	attachment	attachment	NN
cord-342936-43u7afl3	218	10	of	of	IN
cord-342936-43u7afl3	218	11	the	the	DT
cord-342936-43u7afl3	218	12	CBA	CBA	NNP
cord-342936-43u7afl3	218	13	to	to	IN
cord-342936-43u7afl3	218	14	the	the	DT
cord-342936-43u7afl3	218	15	glycans	glycan	NNS
cord-342936-43u7afl3	218	16	of	of	IN
cord-342936-43u7afl3	218	17	gp120	gp120	NNP
cord-342936-43u7afl3	218	18	hinders	hinder	VBZ
cord-342936-43u7afl3	218	19	or	or	CC
cord-342936-43u7afl3	218	20	prevents	prevent	VBZ
cord-342936-43u7afl3	218	21	the	the	DT
cord-342936-43u7afl3	218	22	conformational	conformational	JJ
cord-342936-43u7afl3	218	23	changes	change	NNS
cord-342936-43u7afl3	218	24	and	and	CC
cord-342936-43u7afl3	218	25	flexibility	flexibility	NN
cord-342936-43u7afl3	218	26	of	of	IN
cord-342936-43u7afl3	218	27	gp120	gp120	NNP
cord-342936-43u7afl3	218	28	that	that	WDT
cord-342936-43u7afl3	218	29	are	be	VBP
cord-342936-43u7afl3	218	30	required	require	VBN
cord-342936-43u7afl3	218	31	to	to	TO
cord-342936-43u7afl3	218	32	properly	properly	RB
cord-342936-43u7afl3	218	33	interact	interact	VB
cord-342936-43u7afl3	218	34	with	with	IN
cord-342936-43u7afl3	218	35	the	the	DT
cord-342936-43u7afl3	218	36	cell	cell	NN
cord-342936-43u7afl3	218	37	-	-	HYPH
cord-342936-43u7afl3	218	38	membrane	membrane	NN
cord-342936-43u7afl3	218	39	receptor	receptor	NN
cord-342936-43u7afl3	218	40	,	,	,
cord-342936-43u7afl3	218	41	before	before	IN
cord-342936-43u7afl3	218	42	or	or	CC
cord-342936-43u7afl3	218	43	during	during	IN
cord-342936-43u7afl3	218	44	the	the	DT
cord-342936-43u7afl3	218	45	fusion	fusion	NN
cord-342936-43u7afl3	218	46	process	process	NN
cord-342936-43u7afl3	218	47	.	.	.
cord-342936-43u7afl3	219	1	In	in	IN
cord-342936-43u7afl3	219	2	a	a	DT
cord-342936-43u7afl3	219	3	number	number	NN
cord-342936-43u7afl3	219	4	of	of	IN
cord-342936-43u7afl3	219	5	cases	case	NNS
cord-342936-43u7afl3	219	6	,	,	,
cord-342936-43u7afl3	219	7	it	-PRON-	PRP
cord-342936-43u7afl3	219	8	has	have	VBZ
cord-342936-43u7afl3	219	9	even	even	RB
cord-342936-43u7afl3	219	10	been	be	VBN
cord-342936-43u7afl3	219	11	observed	observe	VBN
cord-342936-43u7afl3	219	12	that	that	IN
cord-342936-43u7afl3	219	13	the	the	DT
cord-342936-43u7afl3	219	14	binding	binding	NN
cord-342936-43u7afl3	219	15	of	of	IN
cord-342936-43u7afl3	219	16	virus	virus	NN
cord-342936-43u7afl3	219	17	particles	particle	NNS
cord-342936-43u7afl3	219	18	to	to	IN
cord-342936-43u7afl3	219	19	their	-PRON-	PRP$
cord-342936-43u7afl3	219	20	target	target	NN
cord-342936-43u7afl3	219	21	cells	cell	NNS
cord-342936-43u7afl3	219	22	can	can	MD
cord-342936-43u7afl3	219	23	be	be	VB
cord-342936-43u7afl3	219	24	enhanced	enhance	VBN
cord-342936-43u7afl3	219	25	in	in	IN
cord-342936-43u7afl3	219	26	the	the	DT
cord-342936-43u7afl3	219	27	presence	presence	NN
cord-342936-43u7afl3	219	28	of	of	IN
cord-342936-43u7afl3	219	29	some	some	DT
cord-342936-43u7afl3	219	30	CBAs	cba	NNS
cord-342936-43u7afl3	219	31	60	60	CD
cord-342936-43u7afl3	219	32	.	.	.
cord-342936-43u7afl3	220	1	This	this	DT
cord-342936-43u7afl3	220	2	phenomenon	phenomenon	NN
cord-342936-43u7afl3	220	3	may	may	MD
cord-342936-43u7afl3	220	4	indicate	indicate	VB
cord-342936-43u7afl3	220	5	that	that	IN
cord-342936-43u7afl3	220	6	some	some	DT
cord-342936-43u7afl3	220	7	sort	sort	NN
cord-342936-43u7afl3	220	8	of	of	IN
cord-342936-43u7afl3	220	9	crosslinking	crosslinking	NN
cord-342936-43u7afl3	220	10	between	between	IN
cord-342936-43u7afl3	220	11	the	the	DT
cord-342936-43u7afl3	220	12	virus	virus	NN
cord-342936-43u7afl3	220	13	particles	particle	NNS
cord-342936-43u7afl3	220	14	and	and	CC
cord-342936-43u7afl3	220	15	the	the	DT
cord-342936-43u7afl3	220	16	cell	cell	NN
cord-342936-43u7afl3	220	17	-	-	HYPH
cord-342936-43u7afl3	220	18	membrane	membrane	NN
cord-342936-43u7afl3	220	19	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	220	20	occurs	occur	VBZ
cord-342936-43u7afl3	220	21	.	.	.
cord-342936-43u7afl3	221	1	Alternatively	alternatively	RB
cord-342936-43u7afl3	221	2	,	,	,
cord-342936-43u7afl3	221	3	CBA	CBA	NNP
cord-342936-43u7afl3	221	4	-	-	HYPH
cord-342936-43u7afl3	221	5	induced	induce	VBN
cord-342936-43u7afl3	221	6	conformational	conformational	JJ
cord-342936-43u7afl3	221	7	changes	change	NNS
cord-342936-43u7afl3	221	8	in	in	IN
cord-342936-43u7afl3	221	9	gp120	gp120	NNP
cord-342936-43u7afl3	221	10	may	may	MD
cord-342936-43u7afl3	221	11	allow	allow	VB
cord-342936-43u7afl3	221	12	a	a	DT
cord-342936-43u7afl3	221	13	more	more	RBR
cord-342936-43u7afl3	221	14	optimal	optimal	JJ
cord-342936-43u7afl3	221	15	interaction	interaction	NN
cord-342936-43u7afl3	221	16	of	of	IN
cord-342936-43u7afl3	221	17	the	the	DT
cord-342936-43u7afl3	221	18	CD4-binding	cd4-binding	NN
cord-342936-43u7afl3	221	19	site	site	NN
cord-342936-43u7afl3	221	20	on	on	IN
cord-342936-43u7afl3	221	21	gp120	gp120	NNP
cord-342936-43u7afl3	221	22	with	with	IN
cord-342936-43u7afl3	221	23	the	the	DT
cord-342936-43u7afl3	221	24	cellular	cellular	JJ
cord-342936-43u7afl3	221	25	receptor	receptor	NN
cord-342936-43u7afl3	221	26	.	.	.
cord-342936-43u7afl3	222	1	It	-PRON-	PRP
cord-342936-43u7afl3	222	2	should	should	MD
cord-342936-43u7afl3	222	3	be	be	VB
cord-342936-43u7afl3	222	4	mentioned	mention	VBN
cord-342936-43u7afl3	222	5	that	that	IN
cord-342936-43u7afl3	222	6	the	the	DT
cord-342936-43u7afl3	222	7	CD4-binding	cd4-binding	NN
cord-342936-43u7afl3	222	8	site	site	NN
cord-342936-43u7afl3	222	9	on	on	IN
cord-342936-43u7afl3	222	10	gp120	gp120	NNP
cord-342936-43u7afl3	222	11	does	do	VBZ
cord-342936-43u7afl3	222	12	not	not	RB
cord-342936-43u7afl3	222	13	contain	contain	VB
cord-342936-43u7afl3	222	14	N	n	CD
cord-342936-43u7afl3	222	15	-	-	HYPH
cord-342936-43u7afl3	222	16	glycans	glycan	NNS
cord-342936-43u7afl3	222	17	,	,	,
cord-342936-43u7afl3	222	18	and	and	CC
cord-342936-43u7afl3	222	19	deletion	deletion	NN
cord-342936-43u7afl3	222	20	of	of	IN
cord-342936-43u7afl3	222	21	N	n	NN
cord-342936-43u7afl3	222	22	-	-	HYPH
cord-342936-43u7afl3	222	23	glycans	glycan	NNS
cord-342936-43u7afl3	222	24	in	in	IN
cord-342936-43u7afl3	222	25	the	the	DT
cord-342936-43u7afl3	222	26	vicinity	vicinity	NN
cord-342936-43u7afl3	222	27	of	of	IN
cord-342936-43u7afl3	222	28	the	the	DT
cord-342936-43u7afl3	222	29	CD4-binding	cd4-binding	NN
cord-342936-43u7afl3	222	30	site	site	NN
cord-342936-43u7afl3	222	31	on	on	IN
cord-342936-43u7afl3	222	32	gp120	gp120	NNP
cord-342936-43u7afl3	223	1	(	(	-LRB-
cord-342936-43u7afl3	223	2	of	of	IN
cord-342936-43u7afl3	223	3	simian	simian	JJ
cord-342936-43u7afl3	223	4	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	223	5	virus	virus	NN
cord-342936-43u7afl3	223	6	strain	strain	NN
cord-342936-43u7afl3	223	7	SIVmac239	SIVmac239	NNP
cord-342936-43u7afl3	223	8	)	)	-RRB-
cord-342936-43u7afl3	223	9	has	have	VBZ
cord-342936-43u7afl3	223	10	been	be	VBN
cord-342936-43u7afl3	223	11	reported	report	VBN
cord-342936-43u7afl3	223	12	to	to	TO
cord-342936-43u7afl3	223	13	increase	increase	VB
cord-342936-43u7afl3	223	14	the	the	DT
cord-342936-43u7afl3	223	15	binding	binding	JJ
cord-342936-43u7afl3	223	16	efficiency	efficiency	NN
cord-342936-43u7afl3	223	17	of	of	IN
cord-342936-43u7afl3	223	18	the	the	DT
cord-342936-43u7afl3	223	19	mutant	mutant	JJ
cord-342936-43u7afl3	223	20	gp120	gp120	NNP
cord-342936-43u7afl3	223	21	with	with	IN
cord-342936-43u7afl3	223	22	CD4	CD4	NNP
cord-342936-43u7afl3	223	23	;	;	:
cord-342936-43u7afl3	223	24	it	-PRON-	PRP
cord-342936-43u7afl3	223	25	was	be	VBD
cord-342936-43u7afl3	223	26	concluded	conclude	VBN
cord-342936-43u7afl3	223	27	that	that	IN
cord-342936-43u7afl3	223	28	Most	Most	JJS
cord-342936-43u7afl3	223	29	pathogens	pathogen	NNS
cord-342936-43u7afl3	223	30	that	that	WDT
cord-342936-43u7afl3	223	31	bind	bind	VBP
cord-342936-43u7afl3	223	32	to	to	IN
cord-342936-43u7afl3	223	33	DC	DC	NNP
cord-342936-43u7afl3	223	34	-	-	HYPH
cord-342936-43u7afl3	223	35	SIGN	sign	NN
cord-342936-43u7afl3	223	36	(	(	-LRB-
cord-342936-43u7afl3	223	37	dendritic	dendritic	JJ
cord-342936-43u7afl3	223	38	cell	cell	NN
cord-342936-43u7afl3	223	39	(	(	-LRB-
cord-342936-43u7afl3	223	40	DC)-specific	dc)-specific	CD
cord-342936-43u7afl3	223	41	intercellular	intercellular	JJ
cord-342936-43u7afl3	223	42	adhesion	adhesion	NN
cord-342936-43u7afl3	223	43	molecule	molecule	NN
cord-342936-43u7afl3	223	44	3	3	CD
cord-342936-43u7afl3	223	45	(	(	-LRB-
cord-342936-43u7afl3	223	46	ICAM-3)-grabbing	icam-3)-grabbe	VBG
cord-342936-43u7afl3	223	47	non	non	JJ
cord-342936-43u7afl3	223	48	-	-	JJ
cord-342936-43u7afl3	223	49	integrin	integrin	JJ
cord-342936-43u7afl3	223	50	)	)	-RRB-
cord-342936-43u7afl3	223	51	cause	cause	VB
cord-342936-43u7afl3	223	52	long	long	RB
cord-342936-43u7afl3	223	53	-	-	HYPH
cord-342936-43u7afl3	223	54	lasting	last	VBG
cord-342936-43u7afl3	223	55	and	and	CC
cord-342936-43u7afl3	223	56	chronic	chronic	JJ
cord-342936-43u7afl3	223	57	infections	infection	NNS
cord-342936-43u7afl3	223	58	,	,	,
cord-342936-43u7afl3	223	59	and	and	CC
cord-342936-43u7afl3	223	60	often	often	RB
cord-342936-43u7afl3	223	61	induce	induce	VBP
cord-342936-43u7afl3	223	62	tolerance	tolerance	NN
cord-342936-43u7afl3	223	63	or	or	CC
cord-342936-43u7afl3	223	64	immune	immune	JJ
cord-342936-43u7afl3	223	65	evasion	evasion	NN
cord-342936-43u7afl3	223	66	74	74	CD
cord-342936-43u7afl3	223	67	.	.	.
cord-342936-43u7afl3	224	1	DC	DC	NNP
cord-342936-43u7afl3	224	2	-	-	HYPH
cord-342936-43u7afl3	224	3	SIGN	SIGN	NNP
cord-342936-43u7afl3	224	4	is	be	VBZ
cord-342936-43u7afl3	224	5	a	a	DT
cord-342936-43u7afl3	224	6	C	c	NN
cord-342936-43u7afl3	224	7	-	-	HYPH
cord-342936-43u7afl3	224	8	type	type	NN
cord-342936-43u7afl3	224	9	(	(	-LRB-
cord-342936-43u7afl3	224	10	calcium	calcium	NN
cord-342936-43u7afl3	224	11	-	-	HYPH
cord-342936-43u7afl3	224	12	dependent	dependent	JJ
cord-342936-43u7afl3	224	13	)	)	-RRB-
cord-342936-43u7afl3	224	14	lectin	lectin	NN
cord-342936-43u7afl3	224	15	that	that	WDT
cord-342936-43u7afl3	224	16	is	be	VBZ
cord-342936-43u7afl3	224	17	predominantly	predominantly	RB
cord-342936-43u7afl3	224	18	expressed	express	VBN
cord-342936-43u7afl3	224	19	on	on	IN
cord-342936-43u7afl3	224	20	DCs	dc	NNS
cord-342936-43u7afl3	224	21	,	,	,
cord-342936-43u7afl3	224	22	but	but	CC
cord-342936-43u7afl3	224	23	also	also	RB
cord-342936-43u7afl3	224	24	to	to	IN
cord-342936-43u7afl3	224	25	some	some	DT
cord-342936-43u7afl3	224	26	extent	extent	NN
cord-342936-43u7afl3	224	27	on	on	IN
cord-342936-43u7afl3	224	28	macrophages	macrophage	NNS
cord-342936-43u7afl3	224	29	,	,	,
cord-342936-43u7afl3	224	30	activated	activate	VBN
cord-342936-43u7afl3	224	31	B	b	NN
cord-342936-43u7afl3	224	32	cells	cell	NNS
cord-342936-43u7afl3	224	33	,	,	,
cord-342936-43u7afl3	224	34	lymphoid	lymphoid	JJ
cord-342936-43u7afl3	224	35	tissues	tissue	NNS
cord-342936-43u7afl3	224	36	,	,	,
cord-342936-43u7afl3	224	37	skin	skin	NN
cord-342936-43u7afl3	224	38	dermis	dermis	NN
cord-342936-43u7afl3	224	39	,	,	,
cord-342936-43u7afl3	224	40	placenta	placenta	NN
cord-342936-43u7afl3	224	41	and	and	CC
cord-342936-43u7afl3	224	42	the	the	DT
cord-342936-43u7afl3	224	43	intestinal	intestinal	JJ
cord-342936-43u7afl3	224	44	and	and	CC
cord-342936-43u7afl3	224	45	genital	genital	JJ
cord-342936-43u7afl3	224	46	mucosa	mucosa	NN
cord-342936-43u7afl3	224	47	.	.	.
cord-342936-43u7afl3	225	1	It	-PRON-	PRP
cord-342936-43u7afl3	225	2	functions	function	VBZ
cord-342936-43u7afl3	225	3	as	as	IN
cord-342936-43u7afl3	225	4	a	a	DT
cord-342936-43u7afl3	225	5	tetramer	tetramer	NN
cord-342936-43u7afl3	225	6	,	,	,
cord-342936-43u7afl3	225	7	and	and	CC
cord-342936-43u7afl3	225	8	consists	consist	VBZ
cord-342936-43u7afl3	225	9	of	of	IN
cord-342936-43u7afl3	225	10	a	a	DT
cord-342936-43u7afl3	225	11	cytoplasmic	cytoplasmic	JJ
cord-342936-43u7afl3	225	12	domain	domain	NN
cord-342936-43u7afl3	225	13	,	,	,
cord-342936-43u7afl3	225	14	a	a	DT
cord-342936-43u7afl3	225	15	transmembrane	transmembrane	NN
cord-342936-43u7afl3	225	16	domain	domain	NN
cord-342936-43u7afl3	225	17	,	,	,
cord-342936-43u7afl3	225	18	an	an	DT
cord-342936-43u7afl3	225	19	exogenous	exogenous	JJ
cord-342936-43u7afl3	225	20	(	(	-LRB-
cord-342936-43u7afl3	225	21	hepta	hepta	NNP
cord-342936-43u7afl3	225	22	)	)	-RRB-
cord-342936-43u7afl3	225	23	repeat	repeat	NN
cord-342936-43u7afl3	225	24	domain	domain	NN
cord-342936-43u7afl3	225	25	that	that	WDT
cord-342936-43u7afl3	225	26	allows	allow	VBZ
cord-342936-43u7afl3	225	27	multimerization	multimerization	NN
cord-342936-43u7afl3	225	28	,	,	,
cord-342936-43u7afl3	225	29	and	and	CC
cord-342936-43u7afl3	225	30	a	a	DT
cord-342936-43u7afl3	225	31	terminal	terminal	JJ
cord-342936-43u7afl3	225	32	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	225	33	(	(	-LRB-
cord-342936-43u7afl3	225	34	high	high	JJ
cord-342936-43u7afl3	225	35	-	-	HYPH
cord-342936-43u7afl3	225	36	mannose)-recognition	mannose)-recognition	NN
cord-342936-43u7afl3	225	37	domain	domain	NN
cord-342936-43u7afl3	225	38	120	120	CD
cord-342936-43u7afl3	225	39	.	.	.
cord-342936-43u7afl3	226	1	DCs	dc	NNS
cord-342936-43u7afl3	226	2	that	that	WDT
cord-342936-43u7afl3	226	3	are	be	VBP
cord-342936-43u7afl3	226	4	present	present	JJ
cord-342936-43u7afl3	226	5	at	at	IN
cord-342936-43u7afl3	226	6	the	the	DT
cord-342936-43u7afl3	226	7	sites	site	NNS
cord-342936-43u7afl3	226	8	of	of	IN
cord-342936-43u7afl3	226	9	pathogen	pathogen	NN
cord-342936-43u7afl3	226	10	entry	entry	NN
cord-342936-43u7afl3	226	11	(	(	-LRB-
cord-342936-43u7afl3	226	12	for	for	IN
cord-342936-43u7afl3	226	13	example	example	NN
cord-342936-43u7afl3	226	14	,	,	,
cord-342936-43u7afl3	226	15	at	at	IN
cord-342936-43u7afl3	226	16	the	the	DT
cord-342936-43u7afl3	226	17	mucosal	mucosal	JJ
cord-342936-43u7afl3	226	18	barrier	barrier	NN
cord-342936-43u7afl3	226	19	underneath	underneath	IN
cord-342936-43u7afl3	226	20	the	the	DT
cord-342936-43u7afl3	226	21	vaginal	vaginal	JJ
cord-342936-43u7afl3	226	22	epithelia	epithelium	NNS
cord-342936-43u7afl3	226	23	)	)	-RRB-
cord-342936-43u7afl3	226	24	recognize	recognize	VBP
cord-342936-43u7afl3	226	25	and	and	CC
cord-342936-43u7afl3	226	26	trap	trap	VB
cord-342936-43u7afl3	226	27	the	the	DT
cord-342936-43u7afl3	226	28	pathogen	pathogen	NN
cord-342936-43u7afl3	226	29	.	.	.
cord-342936-43u7afl3	227	1	The	the	DT
cord-342936-43u7afl3	227	2	activated	activate	VBN
cord-342936-43u7afl3	227	3	DCs	dc	NNS
cord-342936-43u7afl3	227	4	then	then	RB
cord-342936-43u7afl3	227	5	migrate	migrate	VBP
cord-342936-43u7afl3	227	6	to	to	IN
cord-342936-43u7afl3	227	7	draining	drain	VBG
cord-342936-43u7afl3	227	8	lymph	lymph	NN
cord-342936-43u7afl3	227	9	nodes	node	NNS
cord-342936-43u7afl3	227	10	,	,	,
cord-342936-43u7afl3	227	11	where	where	WRB
cord-342936-43u7afl3	227	12	naive	naive	JJ
cord-342936-43u7afl3	227	13	T	t	NN
cord-342936-43u7afl3	227	14	cells	cell	NNS
cord-342936-43u7afl3	227	15	are	be	VBP
cord-342936-43u7afl3	227	16	primed	prime	VBN
cord-342936-43u7afl3	227	17	to	to	TO
cord-342936-43u7afl3	227	18	eradicate	eradicate	VB
cord-342936-43u7afl3	227	19	the	the	DT
cord-342936-43u7afl3	227	20	pathogen	pathogen	NN
cord-342936-43u7afl3	227	21	(	(	-LRB-
cord-342936-43u7afl3	227	22	FIG	fig	NN
cord-342936-43u7afl3	227	23	.	.	.
cord-342936-43u7afl3	227	24	1	1	CD
cord-342936-43u7afl3	227	25	)	)	-RRB-
cord-342936-43u7afl3	227	26	.	.	.
cord-342936-43u7afl3	228	1	One	one	CD
cord-342936-43u7afl3	228	2	of	of	IN
cord-342936-43u7afl3	228	3	the	the	DT
cord-342936-43u7afl3	228	4	roles	role	NNS
cord-342936-43u7afl3	228	5	of	of	IN
cord-342936-43u7afl3	228	6	DC	DC	NNP
cord-342936-43u7afl3	228	7	-	-	HYPH
cord-342936-43u7afl3	228	8	SIGN	SIGN	NNP
cord-342936-43u7afl3	228	9	is	be	VBZ
cord-342936-43u7afl3	228	10	to	to	TO
cord-342936-43u7afl3	228	11	grab	grab	VB
cord-342936-43u7afl3	228	12	ICAM-3	ICAM-3	NNP
cord-342936-43u7afl3	228	13	that	that	WDT
cord-342936-43u7afl3	228	14	is	be	VBZ
cord-342936-43u7afl3	228	15	present	present	JJ
cord-342936-43u7afl3	228	16	on	on	IN
cord-342936-43u7afl3	228	17	T	t	NN
cord-342936-43u7afl3	228	18	cells	cell	NNS
cord-342936-43u7afl3	228	19	to	to	TO
cord-342936-43u7afl3	228	20	enable	enable	VB
cord-342936-43u7afl3	228	21	close	close	JJ
cord-342936-43u7afl3	228	22	contact	contact	NN
cord-342936-43u7afl3	228	23	and	and	CC
cord-342936-43u7afl3	228	24	allow	allow	VB
cord-342936-43u7afl3	228	25	antigen	antigen	NN
cord-342936-43u7afl3	228	26	presentation	presentation	NN
cord-342936-43u7afl3	228	27	to	to	IN
cord-342936-43u7afl3	228	28	the	the	DT
cord-342936-43u7afl3	228	29	T	T	NNP
cord-342936-43u7afl3	228	30	cells	cell	NNS
cord-342936-43u7afl3	228	31	.	.	.
cord-342936-43u7afl3	229	1	DCs	DCs	NNP
cord-342936-43u7afl3	229	2	can	can	MD
cord-342936-43u7afl3	229	3	efficiently	efficiently	RB
cord-342936-43u7afl3	229	4	capture	capture	VB
cord-342936-43u7afl3	229	5	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	229	6	particles	particle	NNS
cord-342936-43u7afl3	229	7	through	through	IN
cord-342936-43u7afl3	229	8	their	-PRON-	PRP$
cord-342936-43u7afl3	229	9	C	c	NN
cord-342936-43u7afl3	229	10	-	-	HYPH
cord-342936-43u7afl3	229	11	type	type	NN
cord-342936-43u7afl3	229	12	lectin	lectin	NN
cord-342936-43u7afl3	229	13	(	(	-LRB-
cord-342936-43u7afl3	229	14	DC	DC	NNP
cord-342936-43u7afl3	229	15	-	-	HYPH
cord-342936-43u7afl3	229	16	SIGN	SIGN	NNP
cord-342936-43u7afl3	229	17	)	)	-RRB-
cord-342936-43u7afl3	229	18	receptors	receptor	NNS
cord-342936-43u7afl3	229	19	.	.	.
cord-342936-43u7afl3	230	1	Following	follow	VBG
cord-342936-43u7afl3	230	2	DC	DC	NNP
cord-342936-43u7afl3	230	3	contact	contact	NN
cord-342936-43u7afl3	230	4	with	with	IN
cord-342936-43u7afl3	230	5	T	t	NN
cord-342936-43u7afl3	230	6	cells	cell	NNS
cord-342936-43u7afl3	230	7	,	,	,
cord-342936-43u7afl3	230	8	virus	virus	NN
cord-342936-43u7afl3	230	9	particles	particle	NNS
cord-342936-43u7afl3	230	10	can	can	MD
cord-342936-43u7afl3	230	11	be	be	VB
cord-342936-43u7afl3	230	12	observed	observe	VBN
cord-342936-43u7afl3	230	13	at	at	IN
cord-342936-43u7afl3	230	14	the	the	DT
cord-342936-43u7afl3	230	15	cell	cell	NN
cord-342936-43u7afl3	230	16	-	-	HYPH
cord-342936-43u7afl3	230	17	cell	cell	NN
cord-342936-43u7afl3	230	18	junctions	junction	NNS
cord-342936-43u7afl3	230	19	,	,	,
cord-342936-43u7afl3	230	20	which	which	WDT
cord-342936-43u7afl3	230	21	possibly	possibly	RB
cord-342936-43u7afl3	230	22	creates	create	VBZ
cord-342936-43u7afl3	230	23	an	an	DT
cord-342936-43u7afl3	230	24	infectious	infectious	JJ
cord-342936-43u7afl3	230	25	synapse	synapse	NN
cord-342936-43u7afl3	230	26	in	in	IN
cord-342936-43u7afl3	230	27	which	which	WDT
cord-342936-43u7afl3	230	28	the	the	DT
cord-342936-43u7afl3	230	29	passage	passage	NN
cord-342936-43u7afl3	230	30	of	of	IN
cord-342936-43u7afl3	230	31	virions	virion	NNS
cord-342936-43u7afl3	230	32	between	between	IN
cord-342936-43u7afl3	230	33	the	the	DT
cord-342936-43u7afl3	230	34	two	two	CD
cord-342936-43u7afl3	230	35	cell	cell	NN
cord-342936-43u7afl3	230	36	types	type	NNS
cord-342936-43u7afl3	230	37	is	be	VBZ
cord-342936-43u7afl3	230	38	facilitated	facilitate	VBN
cord-342936-43u7afl3	230	39	.	.	.
cord-342936-43u7afl3	231	1	Such	such	JJ
cord-342936-43u7afl3	231	2	a	a	DT
cord-342936-43u7afl3	231	3	synapse	synapse	NN
cord-342936-43u7afl3	231	4	depends	depend	VBZ
cord-342936-43u7afl3	231	5	on	on	IN
cord-342936-43u7afl3	231	6	DC	DC	NNP
cord-342936-43u7afl3	231	7	-	-	HYPH
cord-342936-43u7afl3	231	8	SIGN	sign	NN
cord-342936-43u7afl3	231	9	expression	expression	NN
cord-342936-43u7afl3	231	10	and	and	CC
cord-342936-43u7afl3	231	11	strong	strong	JJ
cord-342936-43u7afl3	231	12	cell	cell	NN
cord-342936-43u7afl3	231	13	-	-	HYPH
cord-342936-43u7afl3	231	14	cell	cell	NN
cord-342936-43u7afl3	231	15	adhesion	adhesion	NN
cord-342936-43u7afl3	231	16	mediated	mediate	VBN
cord-342936-43u7afl3	231	17	by	by	IN
cord-342936-43u7afl3	231	18	the	the	DT
cord-342936-43u7afl3	231	19	ICAM-1-LFA-1	ICAM-1-LFA-1	NNS
cord-342936-43u7afl3	231	20	(	(	-LRB-
cord-342936-43u7afl3	231	21	lymphocyte	lymphocyte	NN
cord-342936-43u7afl3	231	22	function	function	NN
cord-342936-43u7afl3	231	23	-	-	HYPH
cord-342936-43u7afl3	231	24	associated	associate	VBN
cord-342936-43u7afl3	231	25	antigen	antigen	NN
cord-342936-43u7afl3	231	26	1	1	CD
cord-342936-43u7afl3	231	27	)	)	-RRB-
cord-342936-43u7afl3	231	28	interaction	interaction	NN
cord-342936-43u7afl3	231	29	.	.	.
cord-342936-43u7afl3	232	1	It	-PRON-	PRP
cord-342936-43u7afl3	232	2	has	have	VBZ
cord-342936-43u7afl3	232	3	been	be	VBN
cord-342936-43u7afl3	232	4	shown	show	VBN
cord-342936-43u7afl3	232	5	that	that	IN
cord-342936-43u7afl3	232	6	,	,	,
cord-342936-43u7afl3	232	7	in	in	IN
cord-342936-43u7afl3	232	8	the	the	DT
cord-342936-43u7afl3	232	9	case	case	NN
cord-342936-43u7afl3	232	10	of	of	IN
cord-342936-43u7afl3	232	11	HIV	HIV	NNP
cord-342936-43u7afl3	232	12	,	,	,
cord-342936-43u7afl3	232	13	the	the	DT
cord-342936-43u7afl3	232	14	infectious	infectious	JJ
cord-342936-43u7afl3	232	15	synapse	synapse	NN
cord-342936-43u7afl3	232	16	leads	lead	VBZ
cord-342936-43u7afl3	232	17	to	to	IN
cord-342936-43u7afl3	232	18	an	an	DT
cord-342936-43u7afl3	232	19	efficient	efficient	JJ
cord-342936-43u7afl3	232	20	transfer	transfer	NN
cord-342936-43u7afl3	232	21	of	of	IN
cord-342936-43u7afl3	232	22	the	the	DT
cord-342936-43u7afl3	232	23	pathogen	pathogen	NN
cord-342936-43u7afl3	232	24	to	to	IN
cord-342936-43u7afl3	232	25	T	t	NN
cord-342936-43u7afl3	232	26	cells	cell	NNS
cord-342936-43u7afl3	232	27	120	120	CD
cord-342936-43u7afl3	232	28	.	.	.
cord-342936-43u7afl3	233	1	certain	certain	JJ
cord-342936-43u7afl3	233	2	glycans	glycan	NNS
cord-342936-43u7afl3	233	3	might	may	MD
cord-342936-43u7afl3	233	4	be	be	VB
cord-342936-43u7afl3	233	5	particularly	particularly	RB
cord-342936-43u7afl3	233	6	important	important	JJ
cord-342936-43u7afl3	233	7	for	for	IN
cord-342936-43u7afl3	233	8	the	the	DT
cord-342936-43u7afl3	233	9	shielding	shielding	NN
cord-342936-43u7afl3	233	10	of	of	IN
cord-342936-43u7afl3	233	11	the	the	DT
cord-342936-43u7afl3	233	12	CD4-binding	cd4-binding	NN
cord-342936-43u7afl3	233	13	site	site	NN
cord-342936-43u7afl3	233	14	from	from	IN
cord-342936-43u7afl3	233	15	antibody	antibody	NN
cord-342936-43u7afl3	233	16	recognition	recognition	NNP
cord-342936-43u7afl3	233	17	83	83	CD
cord-342936-43u7afl3	233	18	.	.	.
cord-342936-43u7afl3	234	1	The	the	DT
cord-342936-43u7afl3	234	2	exposure	exposure	NN
cord-342936-43u7afl3	234	3	of	of	IN
cord-342936-43u7afl3	234	4	HIV	HIV	NNP
cord-342936-43u7afl3	234	5	to	to	IN
cord-342936-43u7afl3	234	6	any	any	DT
cord-342936-43u7afl3	234	7	antiviral	antiviral	JJ
cord-342936-43u7afl3	234	8	drug	drug	NN
cord-342936-43u7afl3	234	9	will	will	MD
cord-342936-43u7afl3	234	10	eventually	eventually	RB
cord-342936-43u7afl3	234	11	result	result	VB
cord-342936-43u7afl3	234	12	in	in	IN
cord-342936-43u7afl3	234	13	the	the	DT
cord-342936-43u7afl3	234	14	appearance	appearance	NN
cord-342936-43u7afl3	234	15	of	of	IN
cord-342936-43u7afl3	234	16	phenotypic	phenotypic	JJ
cord-342936-43u7afl3	234	17	resistance	resistance	NN
cord-342936-43u7afl3	234	18	,	,	,
cord-342936-43u7afl3	234	19	both	both	CC
cord-342936-43u7afl3	234	20	in	in	IN
cord-342936-43u7afl3	234	21	cell	cell	NN
cord-342936-43u7afl3	234	22	culture	culture	NN
cord-342936-43u7afl3	234	23	and	and	CC
cord-342936-43u7afl3	234	24	in	in	IN
cord-342936-43u7afl3	234	25	HIV	HIV	NNP
cord-342936-43u7afl3	234	26	-	-	HYPH
cord-342936-43u7afl3	234	27	infected	infect	VBN
cord-342936-43u7afl3	234	28	individuals	individual	NNS
cord-342936-43u7afl3	234	29	.	.	.
cord-342936-43u7afl3	235	1	Antiviral	antiviral	JJ
cord-342936-43u7afl3	235	2	drug	drug	NN
cord-342936-43u7afl3	235	3	resistance	resistance	NN
cord-342936-43u7afl3	235	4	is	be	VBZ
cord-342936-43u7afl3	235	5	usually	usually	RB
cord-342936-43u7afl3	235	6	due	due	JJ
cord-342936-43u7afl3	235	7	to	to	IN
cord-342936-43u7afl3	235	8	aminoacid	aminoacid	JJ
cord-342936-43u7afl3	235	9	mutations	mutation	NNS
cord-342936-43u7afl3	235	10	and/or	and/or	CC
cord-342936-43u7afl3	235	11	deletions	deletion	NNS
cord-342936-43u7afl3	235	12	in	in	IN
cord-342936-43u7afl3	235	13	the	the	DT
cord-342936-43u7afl3	235	14	viral	viral	JJ
cord-342936-43u7afl3	235	15	target	target	NN
cord-342936-43u7afl3	235	16	with	with	IN
cord-342936-43u7afl3	235	17	which	which	WDT
cord-342936-43u7afl3	235	18	the	the	DT
cord-342936-43u7afl3	235	19	particular	particular	JJ
cord-342936-43u7afl3	235	20	drug	drug	NN
cord-342936-43u7afl3	235	21	directly	directly	RB
cord-342936-43u7afl3	235	22	or	or	CC
cord-342936-43u7afl3	235	23	indirectly	indirectly	RB
cord-342936-43u7afl3	235	24	interacts	interact	VBZ
cord-342936-43u7afl3	235	25	.	.	.
cord-342936-43u7afl3	236	1	In	in	IN
cord-342936-43u7afl3	236	2	many	many	JJ
cord-342936-43u7afl3	236	3	cases	case	NNS
cord-342936-43u7afl3	236	4	,	,	,
cord-342936-43u7afl3	236	5	one	one	CD
cord-342936-43u7afl3	236	6	amino	amino	NN
cord-342936-43u7afl3	236	7	-	-	HYPH
cord-342936-43u7afl3	236	8	acid	acid	NN
cord-342936-43u7afl3	236	9	change	change	NN
cord-342936-43u7afl3	236	10	is	be	VBZ
cord-342936-43u7afl3	236	11	sufficient	sufficient	JJ
cord-342936-43u7afl3	236	12	to	to	TO
cord-342936-43u7afl3	236	13	provoke	provoke	VB
cord-342936-43u7afl3	236	14	a	a	DT
cord-342936-43u7afl3	236	15	marked	marked	JJ
cord-342936-43u7afl3	236	16	degree	degree	NN
cord-342936-43u7afl3	236	17	of	of	IN
cord-342936-43u7afl3	236	18	drug	drug	NN
cord-342936-43u7afl3	236	19	resistance	resistance	NN
cord-342936-43u7afl3	236	20	,	,	,
cord-342936-43u7afl3	236	21	although	although	IN
cord-342936-43u7afl3	236	22	sometimes	sometimes	RB
cord-342936-43u7afl3	236	23	several	several	JJ
cord-342936-43u7afl3	236	24	mutations	mutation	NNS
cord-342936-43u7afl3	236	25	are	be	VBP
cord-342936-43u7afl3	236	26	required	require	VBN
cord-342936-43u7afl3	236	27	before	before	IN
cord-342936-43u7afl3	236	28	pronounced	pronounce	VBN
cord-342936-43u7afl3	236	29	phenotypic	phenotypic	JJ
cord-342936-43u7afl3	236	30	resistance	resistance	NN
cord-342936-43u7afl3	236	31	becomes	become	VBZ
cord-342936-43u7afl3	236	32	evident	evident	JJ
cord-342936-43u7afl3	236	33	.	.	.
cord-342936-43u7afl3	237	1	Viral	viral	JJ
cord-342936-43u7afl3	237	2	fitness	fitness	NN
cord-342936-43u7afl3	237	3	or	or	CC
cord-342936-43u7afl3	237	4	infectivity	infectivity	NN
cord-342936-43u7afl3	237	5	is	be	VBZ
cord-342936-43u7afl3	237	6	often	often	RB
cord-342936-43u7afl3	237	7	compromised	compromise	VBN
cord-342936-43u7afl3	237	8	in	in	IN
cord-342936-43u7afl3	237	9	the	the	DT
cord-342936-43u7afl3	237	10	presence	presence	NN
cord-342936-43u7afl3	237	11	of	of	IN
cord-342936-43u7afl3	237	12	such	such	JJ
cord-342936-43u7afl3	237	13	resistance	resistance	NN
cord-342936-43u7afl3	237	14	mutations	mutation	NNS
cord-342936-43u7afl3	237	15	.	.	.
cord-342936-43u7afl3	238	1	However	however	RB
cord-342936-43u7afl3	238	2	,	,	,
cord-342936-43u7afl3	238	3	compensatory	compensatory	JJ
cord-342936-43u7afl3	238	4	mutations	mutation	NNS
cord-342936-43u7afl3	238	5	may	may	MD
cord-342936-43u7afl3	238	6	also	also	RB
cord-342936-43u7afl3	238	7	occur	occur	VB
cord-342936-43u7afl3	238	8	.	.	.
cord-342936-43u7afl3	239	1	These	these	DT
cord-342936-43u7afl3	239	2	aminoacid	aminoacid	JJ
cord-342936-43u7afl3	239	3	mutations	mutation	NNS
cord-342936-43u7afl3	239	4	do	do	VBP
cord-342936-43u7afl3	239	5	not	not	RB
cord-342936-43u7afl3	239	6	contribute	contribute	VB
cord-342936-43u7afl3	239	7	to	to	IN
cord-342936-43u7afl3	239	8	drug	drug	NN
cord-342936-43u7afl3	239	9	resistance	resistance	NN
cord-342936-43u7afl3	239	10	,	,	,
cord-342936-43u7afl3	239	11	but	but	CC
cord-342936-43u7afl3	239	12	rather	rather	RB
cord-342936-43u7afl3	239	13	are	be	VBP
cord-342936-43u7afl3	239	14	meant	mean	VBN
cord-342936-43u7afl3	239	15	to	to	TO
cord-342936-43u7afl3	239	16	restore	restore	VB
cord-342936-43u7afl3	239	17	the	the	DT
cord-342936-43u7afl3	239	18	fitness	fitness	NN
cord-342936-43u7afl3	239	19	of	of	IN
cord-342936-43u7afl3	239	20	the	the	DT
cord-342936-43u7afl3	239	21	virus	virus	NN
cord-342936-43u7afl3	239	22	.	.	.
cord-342936-43u7afl3	240	1	For	for	IN
cord-342936-43u7afl3	240	2	HIV	HIV	NNP
cord-342936-43u7afl3	240	3	,	,	,
cord-342936-43u7afl3	240	4	exposure	exposure	NN
cord-342936-43u7afl3	240	5	to	to	IN
cord-342936-43u7afl3	240	6	CBAs	cba	NNS
cord-342936-43u7afl3	240	7	invariably	invariably	RB
cord-342936-43u7afl3	240	8	results	result	VBZ
cord-342936-43u7afl3	240	9	in	in	IN
cord-342936-43u7afl3	240	10	the	the	DT
cord-342936-43u7afl3	240	11	appearance	appearance	NN
cord-342936-43u7afl3	240	12	and	and	CC
cord-342936-43u7afl3	240	13	accumulation	accumulation	NN
cord-342936-43u7afl3	240	14	of	of	IN
cord-342936-43u7afl3	240	15	amino	amino	NN
cord-342936-43u7afl3	240	16	-	-	HYPH
cord-342936-43u7afl3	240	17	acid	acid	NN
cord-342936-43u7afl3	240	18	mutations	mutation	NNS
cord-342936-43u7afl3	240	19	,	,	,
cord-342936-43u7afl3	240	20	predominantly	predominantly	RB
cord-342936-43u7afl3	240	21	in	in	IN
cord-342936-43u7afl3	240	22	the	the	DT
cord-342936-43u7afl3	240	23	putative	putative	JJ
cord-342936-43u7afl3	240	24	N	n	CD
cord-342936-43u7afl3	240	25	-	-	HYPH
cord-342936-43u7afl3	240	26	glycosylation	glycosylation	NN
cord-342936-43u7afl3	240	27	motifs	motif	NNS
cord-342936-43u7afl3	240	28	of	of	IN
cord-342936-43u7afl3	240	29	gp120	gp120	NNP
cord-342936-43u7afl3	241	1	(	(	-LRB-
cord-342936-43u7afl3	241	2	REFS	REFS	NNP
cord-342936-43u7afl3	241	3	41	41	CD
cord-342936-43u7afl3	241	4	,	,	,
cord-342936-43u7afl3	241	5	54	54	CD
cord-342936-43u7afl3	241	6	,	,	,
cord-342936-43u7afl3	241	7	60	60	CD
cord-342936-43u7afl3	241	8	,	,	,
cord-342936-43u7afl3	241	9	69	69	CD
cord-342936-43u7afl3	241	10	,	,	,
cord-342936-43u7afl3	241	11	(	(	-LRB-
cord-342936-43u7afl3	241	12	84	84	CD
cord-342936-43u7afl3	241	13	)	)	-RRB-
cord-342936-43u7afl3	241	14	(	(	-LRB-
cord-342936-43u7afl3	241	15	85	85	CD
cord-342936-43u7afl3	241	16	)	)	-RRB-
cord-342936-43u7afl3	241	17	(	(	-LRB-
cord-342936-43u7afl3	241	18	86	86	CD
cord-342936-43u7afl3	241	19	)	)	-RRB-
cord-342936-43u7afl3	241	20	.	.	.
cord-342936-43u7afl3	242	1	Either	either	CC
cord-342936-43u7afl3	242	2	an	an	DT
cord-342936-43u7afl3	242	3	asparagine	asparagine	NN
cord-342936-43u7afl3	242	4	,	,	,
cord-342936-43u7afl3	242	5	or	or	CC
cord-342936-43u7afl3	242	6	a	a	DT
cord-342936-43u7afl3	242	7	serine	serine	NN
cord-342936-43u7afl3	242	8	or	or	CC
cord-342936-43u7afl3	242	9	threonine	threonine	NN
cord-342936-43u7afl3	242	10	,	,	,
cord-342936-43u7afl3	242	11	are	be	VBP
cord-342936-43u7afl3	242	12	mutated	mutate	VBN
cord-342936-43u7afl3	242	13	,	,	,
cord-342936-43u7afl3	242	14	leading	lead	VBG
cord-342936-43u7afl3	242	15	to	to	IN
cord-342936-43u7afl3	242	16	the	the	DT
cord-342936-43u7afl3	242	17	annihilation	annihilation	NN
cord-342936-43u7afl3	242	18	of	of	IN
cord-342936-43u7afl3	242	19	the	the	DT
cord-342936-43u7afl3	242	20	glycosylation	glycosylation	NN
cord-342936-43u7afl3	242	21	site	site	NN
cord-342936-43u7afl3	242	22	.	.	.
cord-342936-43u7afl3	243	1	No	no	DT
cord-342936-43u7afl3	243	2	glycan	glycan	NN
cord-342936-43u7afl3	243	3	deletions	deletion	NNS
cord-342936-43u7afl3	243	4	were	be	VBD
cord-342936-43u7afl3	243	5	observed	observe	VBN
cord-342936-43u7afl3	243	6	,	,	,
cord-342936-43u7afl3	243	7	however	however	RB
cord-342936-43u7afl3	243	8	,	,	,
cord-342936-43u7afl3	243	9	in	in	IN
cord-342936-43u7afl3	243	10	the	the	DT
cord-342936-43u7afl3	243	11	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	243	12	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	243	13	gp41	gp41	NN
cord-342936-43u7afl3	243	14	of	of	IN
cord-342936-43u7afl3	243	15	such	such	JJ
cord-342936-43u7afl3	243	16	mutant	mutant	JJ
cord-342936-43u7afl3	243	17	virus	virus	NN
cord-342936-43u7afl3	243	18	strains	strain	NNS
cord-342936-43u7afl3	243	19	.	.	.
cord-342936-43u7afl3	244	1	The	the	DT
cord-342936-43u7afl3	244	2	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	244	3	gp120	gp120	NNP
cord-342936-43u7afl3	244	4	consists	consist	VBZ
cord-342936-43u7afl3	244	5	of	of	IN
cord-342936-43u7afl3	244	6	approximately	approximately	RB
cord-342936-43u7afl3	244	7	30	30	CD
cord-342936-43u7afl3	244	8	-	-	SYM
cord-342936-43u7afl3	244	9	40	40	CD
cord-342936-43u7afl3	244	10	%	%	NN
cord-342936-43u7afl3	244	11	high	high	JJ
cord-342936-43u7afl3	244	12	-	-	HYPH
cord-342936-43u7afl3	244	13	mannose	mannose	NN
cord-342936-43u7afl3	244	14	-	-	HYPH
cord-342936-43u7afl3	244	15	type	type	NN
cord-342936-43u7afl3	244	16	glycans	glycan	NNS
cord-342936-43u7afl3	244	17	(	(	-LRB-
cord-342936-43u7afl3	244	18	approximately	approximately	RB
cord-342936-43u7afl3	244	19	10	10	CD
cord-342936-43u7afl3	244	20	out	out	IN
cord-342936-43u7afl3	244	21	of	of	IN
cord-342936-43u7afl3	244	22	24	24	CD
cord-342936-43u7afl3	244	23	glycans	glycan	NNS
cord-342936-43u7afl3	244	24	in	in	IN
cord-342936-43u7afl3	244	25	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	244	26	/	/	SYM
cord-342936-43u7afl3	244	27	III	III	NNP
cord-342936-43u7afl3	244	28	B	B	NNP
cord-342936-43u7afl3	244	29	)	)	-RRB-
cord-342936-43u7afl3	244	30	87	87	CD
cord-342936-43u7afl3	244	31	,	,	,
cord-342936-43u7afl3	244	32	88	88	CD
cord-342936-43u7afl3	244	33	(	(	-LRB-
cord-342936-43u7afl3	244	34	FIG	fig	NN
cord-342936-43u7afl3	244	35	.	.	.
cord-342936-43u7afl3	244	36	5a	5a	CD
cord-342936-43u7afl3	244	37	)	)	-RRB-
cord-342936-43u7afl3	244	38	,	,	,
cord-342936-43u7afl3	244	39	which	which	WDT
cord-342936-43u7afl3	244	40	are	be	VBP
cord-342936-43u7afl3	244	41	the	the	DT
cord-342936-43u7afl3	244	42	preferential	preferential	JJ
cord-342936-43u7afl3	244	43	sites	site	NNS
cord-342936-43u7afl3	244	44	for	for	IN
cord-342936-43u7afl3	244	45	glycan	glycan	NN
cord-342936-43u7afl3	244	46	deletions	deletion	NNS
cord-342936-43u7afl3	244	47	that	that	WDT
cord-342936-43u7afl3	244	48	occur	occur	VBP
cord-342936-43u7afl3	244	49	under	under	IN
cord-342936-43u7afl3	244	50	CBA	CBA	NNP
cord-342936-43u7afl3	244	51	pressure	pressure	NN
cord-342936-43u7afl3	244	52	(	(	-LRB-
cord-342936-43u7afl3	244	53	FIG	fig	NN
cord-342936-43u7afl3	244	54	.	.	.
cord-342936-43u7afl3	244	55	5b	5b	CD
cord-342936-43u7afl3	244	56	)	)	-RRB-
cord-342936-43u7afl3	244	57	.	.	.
cord-342936-43u7afl3	245	1	Indeed	indeed	RB
cord-342936-43u7afl3	245	2	,	,	,
cord-342936-43u7afl3	245	3	up	up	IN
cord-342936-43u7afl3	245	4	to	to	TO
cord-342936-43u7afl3	245	5	80	80	CD
cord-342936-43u7afl3	245	6	%	%	NN
cord-342936-43u7afl3	245	7	of	of	IN
cord-342936-43u7afl3	245	8	high	high	JJ
cord-342936-43u7afl3	245	9	-	-	HYPH
cord-342936-43u7afl3	245	10	mannose	mannose	NN
cord-342936-43u7afl3	245	11	-	-	HYPH
cord-342936-43u7afl3	245	12	type	type	NN
cord-342936-43u7afl3	245	13	glycan	glycan	NN
cord-342936-43u7afl3	245	14	sites	site	NNS
cord-342936-43u7afl3	245	15	are	be	VBP
cord-342936-43u7afl3	245	16	affected	affect	VBN
cord-342936-43u7afl3	245	17	in	in	IN
cord-342936-43u7afl3	245	18	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	246	1	gp120	gp120	NNP
cord-342936-43u7afl3	246	2	under	under	IN
cord-342936-43u7afl3	246	3	prolonged	prolong	VBN
cord-342936-43u7afl3	246	4	CBA	CBA	NNP
cord-342936-43u7afl3	246	5	pressure	pressure	NN
cord-342936-43u7afl3	246	6	.	.	.
cord-342936-43u7afl3	247	1	Interestingly	interestingly	RB
cord-342936-43u7afl3	247	2	,	,	,
cord-342936-43u7afl3	247	3	such	such	PDT
cord-342936-43u7afl3	247	4	a	a	DT
cord-342936-43u7afl3	247	5	phenomenon	phenomenon	NN
cord-342936-43u7afl3	247	6	consistently	consistently	RB
cord-342936-43u7afl3	247	7	occurs	occur	VBZ
cord-342936-43u7afl3	247	8	regardless	regardless	RB
cord-342936-43u7afl3	247	9	of	of	IN
cord-342936-43u7afl3	247	10	the	the	DT
cord-342936-43u7afl3	247	11	nature	nature	NN
cord-342936-43u7afl3	247	12	of	of	IN
cord-342936-43u7afl3	247	13	the	the	DT
cord-342936-43u7afl3	247	14	CBA	CBA	NNP
cord-342936-43u7afl3	247	15	,	,	,
cord-342936-43u7afl3	247	16	and	and	CC
cord-342936-43u7afl3	247	17	has	have	VBZ
cord-342936-43u7afl3	247	18	been	be	VBN
cord-342936-43u7afl3	247	19	observed	observe	VBN
cord-342936-43u7afl3	247	20	in	in	IN
cord-342936-43u7afl3	247	21	the	the	DT
cord-342936-43u7afl3	247	22	presence	presence	NN
cord-342936-43u7afl3	247	23	of	of	IN
cord-342936-43u7afl3	247	24	the	the	DT
cord-342936-43u7afl3	247	25	α(1,2)-Man	α(1,2)-man	RB
cord-342936-43u7afl3	247	26	-	-	HYPH
cord-342936-43u7afl3	247	27	specific	specific	JJ
cord-342936-43u7afl3	247	28	CV	CV	NNP
cord-342936-43u7afl3	247	29	-	-	HYPH
cord-342936-43u7afl3	247	30	N	N	NNP
cord-342936-43u7afl3	247	31	69	69	CD
cord-342936-43u7afl3	247	32	and	and	CC
cord-342936-43u7afl3	248	1	PRM	PRM	NNP
cord-342936-43u7afl3	248	2	-	-	HYPH
cord-342936-43u7afl3	248	3	A	A	NNP
cord-342936-43u7afl3	248	4	60	60	CD
cord-342936-43u7afl3	248	5	,	,	,
cord-342936-43u7afl3	248	6	the	the	DT
cord-342936-43u7afl3	248	7	α(1,3)-and	α(1,3)-and	NN
cord-342936-43u7afl3	248	8	/	/	SYM
cord-342936-43u7afl3	248	9	or	or	CC
cord-342936-43u7afl3	248	10	α(1,6)-Manspecific	α(1,6)-manspecific	JJ
cord-342936-43u7afl3	248	11	plant	plant	NN
cord-342936-43u7afl3	248	12	lectins	lectin	NNS
cord-342936-43u7afl3	248	13	(	(	-LRB-
cord-342936-43u7afl3	248	14	HHA	HHA	NNP
cord-342936-43u7afl3	248	15	and	and	CC
cord-342936-43u7afl3	248	16	GNA	GNA	NNP
cord-342936-43u7afl3	248	17	)	)	-RRB-
cord-342936-43u7afl3	248	18	84	84	CD
cord-342936-43u7afl3	248	19	,	,	,
cord-342936-43u7afl3	248	20	85	85	CD
cord-342936-43u7afl3	248	21	,	,	,
cord-342936-43u7afl3	248	22	the	the	DT
cord-342936-43u7afl3	248	23	GlcNAcspecific	glcnacspecific	JJ
cord-342936-43u7afl3	248	24	plant	plant	NN
cord-342936-43u7afl3	248	25	lectin	lectin	NN
cord-342936-43u7afl3	248	26	UDA	UDA	NNP
cord-342936-43u7afl3	248	27	41	41	CD
cord-342936-43u7afl3	248	28	and	and	CC
cord-342936-43u7afl3	248	29	the	the	DT
cord-342936-43u7afl3	248	30	N	n	CD
cord-342936-43u7afl3	248	31	-	-	HYPH
cord-342936-43u7afl3	248	32	glycan	glycan	NN
cord-342936-43u7afl3	248	33	-	-	HYPH
cord-342936-43u7afl3	248	34	recognizing	recognize	VBG
cord-342936-43u7afl3	248	35	monoclonal	monoclonal	JJ
cord-342936-43u7afl3	248	36	antibody	antibody	NN
cord-342936-43u7afl3	248	37	2G12	2g12	CD
cord-342936-43u7afl3	249	1	(	(	-LRB-
cord-342936-43u7afl3	249	2	REF	ref	NN
cord-342936-43u7afl3	249	3	.	.	.
cord-342936-43u7afl3	249	4	54	54	CD
cord-342936-43u7afl3	249	5	)	)	-RRB-
cord-342936-43u7afl3	249	6	.	.	.
cord-342936-43u7afl3	250	1	There	there	EX
cord-342936-43u7afl3	250	2	is	be	VBZ
cord-342936-43u7afl3	250	3	a	a	DT
cord-342936-43u7afl3	250	4	close	close	JJ
cord-342936-43u7afl3	250	5	correlation	correlation	NN
cord-342936-43u7afl3	250	6	between	between	IN
cord-342936-43u7afl3	250	7	the	the	DT
cord-342936-43u7afl3	250	8	number	number	NN
cord-342936-43u7afl3	250	9	of	of	IN
cord-342936-43u7afl3	250	10	glycan	glycan	NN
cord-342936-43u7afl3	250	11	deletions	deletion	NNS
cord-342936-43u7afl3	250	12	in	in	IN
cord-342936-43u7afl3	250	13	the	the	DT
cord-342936-43u7afl3	250	14	envelope	envelope	NN
cord-342936-43u7afl3	250	15	of	of	IN
cord-342936-43u7afl3	250	16	a	a	DT
cord-342936-43u7afl3	250	17	particular	particular	JJ
cord-342936-43u7afl3	250	18	HIV	HIV	NNP
cord-342936-43u7afl3	250	19	strain	strain	NN
cord-342936-43u7afl3	250	20	and	and	CC
cord-342936-43u7afl3	250	21	the	the	DT
cord-342936-43u7afl3	250	22	degree	degree	NN
cord-342936-43u7afl3	250	23	of	of	IN
cord-342936-43u7afl3	250	24	phenotypic	phenotypic	JJ
cord-342936-43u7afl3	250	25	drug	drug	NN
cord-342936-43u7afl3	250	26	resistance	resistance	NN
cord-342936-43u7afl3	250	27	and	and	CC
cord-342936-43u7afl3	250	28	,	,	,
cord-342936-43u7afl3	250	29	in	in	IN
cord-342936-43u7afl3	250	30	general	general	JJ
cord-342936-43u7afl3	250	31	,	,	,
cord-342936-43u7afl3	250	32	the	the	DT
cord-342936-43u7afl3	250	33	greater	great	JJR
cord-342936-43u7afl3	250	34	the	the	DT
cord-342936-43u7afl3	250	35	number	number	NN
cord-342936-43u7afl3	250	36	of	of	IN
cord-342936-43u7afl3	250	37	glycan	glycan	NN
cord-342936-43u7afl3	250	38	deletions	deletion	NNS
cord-342936-43u7afl3	250	39	in	in	IN
cord-342936-43u7afl3	250	40	HIV	HIV	NNP
cord-342936-43u7afl3	250	41	gp120	gp120	NNP
cord-342936-43u7afl3	250	42	,	,	,
cord-342936-43u7afl3	250	43	the	the	DT
cord-342936-43u7afl3	250	44	greater	great	JJR
cord-342936-43u7afl3	250	45	the	the	DT
cord-342936-43u7afl3	250	46	degree	degree	NN
cord-342936-43u7afl3	250	47	of	of	IN
cord-342936-43u7afl3	250	48	CBA	CBA	NNP
cord-342936-43u7afl3	250	49	resistance	resistance	NN
cord-342936-43u7afl3	250	50	41	41	CD
cord-342936-43u7afl3	250	51	,	,	,
cord-342936-43u7afl3	250	52	84	84	CD
cord-342936-43u7afl3	250	53	,	,	,
cord-342936-43u7afl3	250	54	85	85	CD
cord-342936-43u7afl3	250	55	.	.	.
cord-342936-43u7afl3	251	1	However	however	RB
cord-342936-43u7afl3	251	2	,	,	,
cord-342936-43u7afl3	251	3	when	when	WRB
cord-342936-43u7afl3	251	4	the	the	DT
cord-342936-43u7afl3	251	5	first	first	JJ
cord-342936-43u7afl3	251	6	glycosylation	glycosylation	NN
cord-342936-43u7afl3	251	7	-	-	HYPH
cord-342936-43u7afl3	251	8	site	site	NN
cord-342936-43u7afl3	251	9	deletions	deletion	NNS
cord-342936-43u7afl3	251	10	occur	occur	VBP
cord-342936-43u7afl3	251	11	under	under	IN
cord-342936-43u7afl3	251	12	CBA	CBA	NNP
cord-342936-43u7afl3	251	13	pressure	pressure	NN
cord-342936-43u7afl3	251	14	in	in	IN
cord-342936-43u7afl3	251	15	HIV	HIV	NNP
cord-342936-43u7afl3	251	16	-	-	HYPH
cord-342936-43u7afl3	251	17	infected	infect	VBN
cord-342936-43u7afl3	251	18	cell	cell	NN
cord-342936-43u7afl3	251	19	cultures	culture	NNS
cord-342936-43u7afl3	251	20	,	,	,
cord-342936-43u7afl3	251	21	phenotypic	phenotypic	JJ
cord-342936-43u7afl3	251	22	resistance	resistance	NN
cord-342936-43u7afl3	251	23	is	be	VBZ
cord-342936-43u7afl3	251	24	rarely	rarely	RB
cord-342936-43u7afl3	251	25	observed	observe	VBN
cord-342936-43u7afl3	251	26	.	.	.
cord-342936-43u7afl3	252	1	For	for	IN
cord-342936-43u7afl3	252	2	example	example	NN
cord-342936-43u7afl3	252	3	,	,	,
cord-342936-43u7afl3	252	4	mutant	mutant	JJ
cord-342936-43u7afl3	252	5	virus	virus	NN
cord-342936-43u7afl3	252	6	strains	strain	NNS
cord-342936-43u7afl3	252	7	have	have	VBP
cord-342936-43u7afl3	252	8	been	be	VBN
cord-342936-43u7afl3	252	9	isolated	isolate	VBN
cord-342936-43u7afl3	252	10	that	that	WDT
cord-342936-43u7afl3	252	11	contain	contain	VBP
cord-342936-43u7afl3	252	12	at	at	IN
cord-342936-43u7afl3	252	13	least	least	RBS
cord-342936-43u7afl3	252	14	three	three	CD
cord-342936-43u7afl3	252	15	or	or	CC
cord-342936-43u7afl3	252	16	more	more	JJR
cord-342936-43u7afl3	252	17	glycosylation	glycosylation	NN
cord-342936-43u7afl3	252	18	-	-	HYPH
cord-342936-43u7afl3	252	19	site	site	NN
cord-342936-43u7afl3	252	20	mutations	mutation	NNS
cord-342936-43u7afl3	252	21	in	in	IN
cord-342936-43u7afl3	252	22	gp120	gp120	NNP
cord-342936-43u7afl3	252	23	without	without	IN
cord-342936-43u7afl3	252	24	the	the	DT
cord-342936-43u7afl3	252	25	appearance	appearance	NN
cord-342936-43u7afl3	252	26	of	of	IN
cord-342936-43u7afl3	252	27	visible	visible	JJ
cord-342936-43u7afl3	252	28	phenotypic	phenotypic	JJ
cord-342936-43u7afl3	252	29	resistance	resistance	NN
cord-342936-43u7afl3	252	30	to	to	IN
cord-342936-43u7afl3	252	31	the	the	DT
cord-342936-43u7afl3	252	32	GlcNAc	GlcNAc	NNP
cord-342936-43u7afl3	252	33	-	-	HYPH
cord-342936-43u7afl3	252	34	specific	specific	JJ
cord-342936-43u7afl3	252	35	UDA	UDA	NNP
cord-342936-43u7afl3	252	36	41	41	CD
cord-342936-43u7afl3	252	37	,	,	,
cord-342936-43u7afl3	252	38	85	85	CD
cord-342936-43u7afl3	252	39	.	.	.
cord-342936-43u7afl3	253	1	Therefore	therefore	RB
cord-342936-43u7afl3	253	2	,	,	,
cord-342936-43u7afl3	253	3	there	there	EX
cord-342936-43u7afl3	253	4	seems	seem	VBZ
cord-342936-43u7afl3	253	5	to	to	TO
cord-342936-43u7afl3	253	6	be	be	VB
cord-342936-43u7afl3	253	7	a	a	DT
cord-342936-43u7afl3	253	8	threshold	threshold	NN
cord-342936-43u7afl3	253	9	for	for	IN
cord-342936-43u7afl3	253	10	the	the	DT
cord-342936-43u7afl3	253	11	number	number	NN
cord-342936-43u7afl3	253	12	of	of	IN
cord-342936-43u7afl3	253	13	glycan	glycan	NN
cord-342936-43u7afl3	253	14	deletions	deletion	NNS
cord-342936-43u7afl3	253	15	below	below	IN
cord-342936-43u7afl3	253	16	which	which	WDT
cord-342936-43u7afl3	254	1	no	no	DT
cord-342936-43u7afl3	254	2	significant	significant	JJ
cord-342936-43u7afl3	254	3	phenotypic	phenotypic	NN
cord-342936-43u7afl3	254	4	CBA	CBA	NNP
cord-342936-43u7afl3	254	5	resistance	resistance	NN
cord-342936-43u7afl3	254	6	is	be	VBZ
cord-342936-43u7afl3	254	7	evident	evident	JJ
cord-342936-43u7afl3	254	8	.	.	.
cord-342936-43u7afl3	255	1	So	so	RB
cord-342936-43u7afl3	255	2	far	far	RB
cord-342936-43u7afl3	255	3	,	,	,
cord-342936-43u7afl3	255	4	many	many	JJ
cord-342936-43u7afl3	255	5	mutant	mutant	JJ
cord-342936-43u7afl3	255	6	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	255	7	strains	strain	NNS
cord-342936-43u7afl3	255	8	containing	contain	VBG
cord-342936-43u7afl3	255	9	up	up	RP
cord-342936-43u7afl3	255	10	to	to	TO
cord-342936-43u7afl3	255	11	nine	nine	CD
cord-342936-43u7afl3	255	12	glycan	glycan	NN
cord-342936-43u7afl3	255	13	deletions	deletion	NNS
cord-342936-43u7afl3	255	14	in	in	IN
cord-342936-43u7afl3	255	15	gp120	gp120	NNP
cord-342936-43u7afl3	255	16	have	have	VBP
cord-342936-43u7afl3	255	17	been	be	VBN
cord-342936-43u7afl3	255	18	isolated	isolate	VBN
cord-342936-43u7afl3	255	19	under	under	IN
cord-342936-43u7afl3	255	20	escalating	escalate	VBG
cord-342936-43u7afl3	255	21	CBA	CBA	NNP
cord-342936-43u7afl3	255	22	pressure	pressure	NN
cord-342936-43u7afl3	255	23	41	41	CD
cord-342936-43u7afl3	255	24	and	and	CC
cord-342936-43u7afl3	255	25	such	such	JJ
cord-342936-43u7afl3	255	26	mutant	mutant	JJ
cord-342936-43u7afl3	255	27	virus	virus	NN
cord-342936-43u7afl3	255	28	strains	strain	NNS
cord-342936-43u7afl3	255	29	can	can	MD
cord-342936-43u7afl3	255	30	be	be	VB
cord-342936-43u7afl3	255	31	up	up	IN
cord-342936-43u7afl3	255	32	to	to	TO
cord-342936-43u7afl3	255	33	100-fold	100-fold	CD
cord-342936-43u7afl3	255	34	less	less	RBR
cord-342936-43u7afl3	255	35	sensitive	sensitive	JJ
cord-342936-43u7afl3	255	36	to	to	IN
cord-342936-43u7afl3	255	37	some	some	DT
cord-342936-43u7afl3	255	38	CBAs	cba	NNS
cord-342936-43u7afl3	255	39	.	.	.
cord-342936-43u7afl3	256	1	Interestingly	interestingly	RB
cord-342936-43u7afl3	256	2	,	,	,
cord-342936-43u7afl3	256	3	several	several	JJ
cord-342936-43u7afl3	256	4	of	of	IN
cord-342936-43u7afl3	256	5	these	these	DT
cord-342936-43u7afl3	256	6	mutant	mutant	JJ
cord-342936-43u7afl3	256	7	virus	virus	NN
cord-342936-43u7afl3	256	8	strains	strain	NNS
cord-342936-43u7afl3	256	9	are	be	VBP
cord-342936-43u7afl3	256	10	less	less	RBR
cord-342936-43u7afl3	256	11	infective	infective	JJ
cord-342936-43u7afl3	256	12	,	,	,
cord-342936-43u7afl3	256	13	resulting	result	VBG
cord-342936-43u7afl3	256	14	in	in	IN
cord-342936-43u7afl3	256	15	a	a	DT
cord-342936-43u7afl3	256	16	lower	low	JJR
cord-342936-43u7afl3	256	17	viral	viral	JJ
cord-342936-43u7afl3	256	18	fitness	fitness	NN
cord-342936-43u7afl3	256	19	compared	compare	VBN
cord-342936-43u7afl3	256	20	with	with	IN
cord-342936-43u7afl3	256	21	the	the	DT
cord-342936-43u7afl3	256	22	wild	wild	JJ
cord-342936-43u7afl3	256	23	-	-	HYPH
cord-342936-43u7afl3	256	24	type	type	NN
cord-342936-43u7afl3	256	25	virus	virus	NN
cord-342936-43u7afl3	256	26	60	60	CD
cord-342936-43u7afl3	256	27	.	.	.
cord-342936-43u7afl3	257	1	However	however	RB
cord-342936-43u7afl3	257	2	,	,	,
cord-342936-43u7afl3	257	3	in	in	IN
cord-342936-43u7afl3	257	4	a	a	DT
cord-342936-43u7afl3	257	5	few	few	JJ
cord-342936-43u7afl3	257	6	cases	case	NNS
cord-342936-43u7afl3	257	7	,	,	,
cord-342936-43u7afl3	257	8	mutant	mutant	JJ
cord-342936-43u7afl3	257	9	virus	virus	NN
cord-342936-43u7afl3	257	10	strains	strain	NNS
cord-342936-43u7afl3	257	11	have	have	VBP
cord-342936-43u7afl3	257	12	been	be	VBN
cord-342936-43u7afl3	257	13	isolated	isolate	VBN
cord-342936-43u7afl3	257	14	that	that	WDT
cord-342936-43u7afl3	257	15	contain	contain	VBP
cord-342936-43u7afl3	257	16	4	4	CD
cord-342936-43u7afl3	257	17	to	to	TO
cord-342936-43u7afl3	257	18	5	5	CD
cord-342936-43u7afl3	257	19	glycan	glycan	NN
cord-342936-43u7afl3	257	20	deletions	deletion	NNS
cord-342936-43u7afl3	257	21	in	in	IN
cord-342936-43u7afl3	257	22	gp120	gp120	NNP
cord-342936-43u7afl3	257	23	,	,	,
cord-342936-43u7afl3	257	24	yet	yet	CC
cord-342936-43u7afl3	257	25	have	have	VBP
cord-342936-43u7afl3	257	26	an	an	DT
cord-342936-43u7afl3	257	27	increased	increase	VBN
cord-342936-43u7afl3	257	28	infectivity	infectivity	NN
cord-342936-43u7afl3	257	29	and	and	CC
cord-342936-43u7afl3	257	30	fitness	fitness	NN
cord-342936-43u7afl3	257	31	85	85	CD
cord-342936-43u7afl3	257	32	.	.	.
cord-342936-43u7afl3	258	1	It	-PRON-	PRP
cord-342936-43u7afl3	258	2	is	be	VBZ
cord-342936-43u7afl3	258	3	unclear	unclear	JJ
cord-342936-43u7afl3	258	4	what	what	WDT
cord-342936-43u7afl3	258	5	structural	structural	JJ
cord-342936-43u7afl3	258	6	requirements	requirement	NNS
cord-342936-43u7afl3	258	7	the	the	DT
cord-342936-43u7afl3	258	8	mutant	mutant	JJ
cord-342936-43u7afl3	258	9	gp120	gp120	NNP
cord-342936-43u7afl3	258	10	must	must	MD
cord-342936-43u7afl3	258	11	fulfill	fulfill	VB
cord-342936-43u7afl3	258	12	to	to	TO
cord-342936-43u7afl3	258	13	have	have	VB
cord-342936-43u7afl3	258	14	an	an	DT
cord-342936-43u7afl3	258	15	increased	increase	VBN
cord-342936-43u7afl3	258	16	infectivity	infectivity	NN
cord-342936-43u7afl3	258	17	.	.	.
cord-342936-43u7afl3	259	1	However	however	RB
cord-342936-43u7afl3	259	2	,	,	,
cord-342936-43u7afl3	259	3	such	such	JJ
cord-342936-43u7afl3	259	4	virus	virus	NN
cord-342936-43u7afl3	259	5	strains	strain	NNS
cord-342936-43u7afl3	259	6	have	have	VBP
cord-342936-43u7afl3	259	7	never	never	RB
cord-342936-43u7afl3	259	8	been	be	VBN
cord-342936-43u7afl3	259	9	observed	observe	VBN
cord-342936-43u7afl3	259	10	to	to	TO
cord-342936-43u7afl3	259	11	emerge	emerge	VB
cord-342936-43u7afl3	259	12	when	when	WRB
cord-342936-43u7afl3	259	13	more	more	JJR
cord-342936-43u7afl3	259	14	than	than	IN
cord-342936-43u7afl3	259	15	five	five	CD
cord-342936-43u7afl3	259	16	glycans	glycan	NNS
cord-342936-43u7afl3	259	17	were	be	VBD
cord-342936-43u7afl3	259	18	concomitantly	concomitantly	RB
cord-342936-43u7afl3	259	19	affected	affect	VBN
cord-342936-43u7afl3	259	20	in	in	IN
cord-342936-43u7afl3	259	21	gp120	gp120	NNP
cord-342936-43u7afl3	259	22	.	.	.
cord-342936-43u7afl3	260	1	In	in	IN
cord-342936-43u7afl3	260	2	fact	fact	NN
cord-342936-43u7afl3	260	3	,	,	,
cord-342936-43u7afl3	260	4	among	among	IN
cord-342936-43u7afl3	260	5	more	more	JJR
cord-342936-43u7afl3	260	6	than	than	IN
cord-342936-43u7afl3	260	7	fifty	fifty	CD
cord-342936-43u7afl3	260	8	independent	independent	JJ
cord-342936-43u7afl3	260	9	mutant	mutant	JJ
cord-342936-43u7afl3	260	10	virus	virus	NN
cord-342936-43u7afl3	260	11	isolates	isolate	VBZ
cord-342936-43u7afl3	260	12	that	that	WDT
cord-342936-43u7afl3	260	13	emerged	emerge	VBD
cord-342936-43u7afl3	260	14	under	under	IN
cord-342936-43u7afl3	260	15	CBA	CBA	NNP
cord-342936-43u7afl3	260	16	pressure	pressure	NN
cord-342936-43u7afl3	260	17	,	,	,
cord-342936-43u7afl3	260	18	only	only	RB
cord-342936-43u7afl3	260	19	three	three	CD
cord-342936-43u7afl3	260	20	were	be	VBD
cord-342936-43u7afl3	260	21	demonstrated	demonstrate	VBN
cord-342936-43u7afl3	260	22	to	to	TO
cord-342936-43u7afl3	260	23	have	have	VB
cord-342936-43u7afl3	260	24	an	an	DT
cord-342936-43u7afl3	260	25	increased	increase	VBN
cord-342936-43u7afl3	260	26	infectivity	infectivity	NN
cord-342936-43u7afl3	260	27	.	.	.
cord-342936-43u7afl3	261	1	There	there	EX
cord-342936-43u7afl3	261	2	is	be	VBZ
cord-342936-43u7afl3	261	3	much	much	JJ
cord-342936-43u7afl3	261	4	evidence	evidence	NN
cord-342936-43u7afl3	261	5	indicating	indicate	VBG
cord-342936-43u7afl3	261	6	that	that	IN
cord-342936-43u7afl3	261	7	the	the	DT
cord-342936-43u7afl3	261	8	glycan	glycan	NN
cord-342936-43u7afl3	261	9	shield	shield	NN
cord-342936-43u7afl3	261	10	of	of	IN
cord-342936-43u7afl3	261	11	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	261	12	prevents	prevent	VBZ
cord-342936-43u7afl3	261	13	the	the	DT
cord-342936-43u7afl3	261	14	immune	immune	JJ
cord-342936-43u7afl3	261	15	system	system	NN
cord-342936-43u7afl3	261	16	from	from	IN
cord-342936-43u7afl3	261	17	efficiently	efficiently	RB
cord-342936-43u7afl3	261	18	neutralizing	neutralize	VBG
cord-342936-43u7afl3	261	19	the	the	DT
cord-342936-43u7afl3	261	20	virus	virus	NN
cord-342936-43u7afl3	261	21	.	.	.
cord-342936-43u7afl3	262	1	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	262	2	strains	strain	NNS
cord-342936-43u7afl3	262	3	lacking	lack	VBG
cord-342936-43u7afl3	262	4	the	the	DT
cord-342936-43u7afl3	262	5	highly	highly	RB
cord-342936-43u7afl3	262	6	conserved	conserved	JJ
cord-342936-43u7afl3	262	7	N	n	NN
cord-342936-43u7afl3	262	8	-	-	HYPH
cord-342936-43u7afl3	262	9	linked	link	VBN
cord-342936-43u7afl3	262	10	glycan	glycan	NN
cord-342936-43u7afl3	262	11	at	at	IN
cord-342936-43u7afl3	262	12	position	position	NN
cord-342936-43u7afl3	262	13	306	306	CD
cord-342936-43u7afl3	262	14	(	(	-LRB-
cord-342936-43u7afl3	262	15	designated	designate	VBN
cord-342936-43u7afl3	262	16	as	as	IN
cord-342936-43u7afl3	262	17	301	301	CD
cord-342936-43u7afl3	262	18	in	in	IN
cord-342936-43u7afl3	262	19	Fig	Fig	NNP
cord-342936-43u7afl3	262	20	.	.	.
cord-342936-43u7afl3	263	1	5	5	LS
cord-342936-43u7afl3	264	1	owing	owe	VBG
cord-342936-43u7afl3	264	2	to	to	IN
cord-342936-43u7afl3	264	3	a	a	DT
cord-342936-43u7afl3	264	4	different	different	JJ
cord-342936-43u7afl3	264	5	numbering	numbering	NN
cord-342936-43u7afl3	264	6	of	of	IN
cord-342936-43u7afl3	264	7	the	the	DT
cord-342936-43u7afl3	264	8	amino	amino	NN
cord-342936-43u7afl3	264	9	acids	acid	NNS
cord-342936-43u7afl3	264	10	)	)	-RRB-
cord-342936-43u7afl3	264	11	within	within	IN
cord-342936-43u7afl3	264	12	the	the	DT
cord-342936-43u7afl3	264	13	V3	V3	NNP
cord-342936-43u7afl3	264	14	loop	loop	NN
cord-342936-43u7afl3	264	15	of	of	IN
cord-342936-43u7afl3	264	16	gp120	gp120	NNP
cord-342936-43u7afl3	264	17	are	be	VBP
cord-342936-43u7afl3	264	18	highly	highly	RB
cord-342936-43u7afl3	264	19	sensitive	sensitive	JJ
cord-342936-43u7afl3	264	20	to	to	IN
cord-342936-43u7afl3	264	21	neutralization	neutralization	NN
cord-342936-43u7afl3	264	22	.	.	.
cord-342936-43u7afl3	265	1	Bolmstedt	Bolmstedt	NNP
cord-342936-43u7afl3	265	2	and	and	CC
cord-342936-43u7afl3	265	3	co	co	NNS
cord-342936-43u7afl3	265	4	-	-	NNS
cord-342936-43u7afl3	265	5	workers	worker	NNS
cord-342936-43u7afl3	265	6	89	89	CD
cord-342936-43u7afl3	265	7	also	also	RB
cord-342936-43u7afl3	265	8	showed	show	VBD
cord-342936-43u7afl3	265	9	that	that	IN
cord-342936-43u7afl3	265	10	glycosylation	glycosylation	NN
cord-342936-43u7afl3	265	11	at	at	IN
cord-342936-43u7afl3	265	12	this	this	DT
cord-342936-43u7afl3	265	13	amino	amino	NN
cord-342936-43u7afl3	265	14	-	-	HYPH
cord-342936-43u7afl3	265	15	acid	acid	NN
cord-342936-43u7afl3	265	16	position	position	NN
cord-342936-43u7afl3	265	17	shields	shield	VBZ
cord-342936-43u7afl3	265	18	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	265	19	from	from	IN
cord-342936-43u7afl3	265	20	neutralizing	neutralize	VBG
cord-342936-43u7afl3	265	21	antibodies	antibody	NNS
cord-342936-43u7afl3	265	22	.	.	.
cord-342936-43u7afl3	266	1	Kang	Kang	NNP
cord-342936-43u7afl3	266	2	and	and	CC
cord-342936-43u7afl3	266	3	colleagues	colleague	NNS
cord-342936-43u7afl3	266	4	90	90	CD
cord-342936-43u7afl3	266	5	recently	recently	RB
cord-342936-43u7afl3	266	6	reported	report	VBD
cord-342936-43u7afl3	266	7	that	that	IN
cord-342936-43u7afl3	266	8	HIV	HIV	NNP
cord-342936-43u7afl3	266	9	env	env	NN
cord-342936-43u7afl3	266	10	-	-	HYPH
cord-342936-43u7afl3	266	11	encoded	encode	VBN
cord-342936-43u7afl3	266	12	proteins	protein	NNS
cord-342936-43u7afl3	266	13	,	,	,
cord-342936-43u7afl3	266	14	with	with	IN
cord-342936-43u7afl3	266	15	deleted	delete	VBN
cord-342936-43u7afl3	266	16	glycans	glycan	NNS
cord-342936-43u7afl3	266	17	in	in	IN
cord-342936-43u7afl3	266	18	the	the	DT
cord-342936-43u7afl3	266	19	gp120	gp120	NNP
cord-342936-43u7afl3	266	20	domains	domain	NNS
cord-342936-43u7afl3	266	21	surrounding	surround	VBG
cord-342936-43u7afl3	266	22	the	the	DT
cord-342936-43u7afl3	266	23	CD4	CD4	NNP
cord-342936-43u7afl3	266	24	binding	bind	VBG
cord-342936-43u7afl3	266	25	site	site	NN
cord-342936-43u7afl3	266	26	,	,	,
cord-342936-43u7afl3	266	27	or	or	CC
cord-342936-43u7afl3	266	28	in	in	IN
cord-342936-43u7afl3	266	29	the	the	DT
cord-342936-43u7afl3	266	30	gp120	gp120	CD
cord-342936-43u7afl3	266	31	variable	variable	JJ
cord-342936-43u7afl3	266	32	loop	loop	NN
cord-342936-43u7afl3	266	33	,	,	,
cord-342936-43u7afl3	266	34	expose	expose	VB
cord-342936-43u7afl3	266	35	immunogenic	immunogenic	JJ
cord-342936-43u7afl3	266	36	epitopes	epitope	NNS
cord-342936-43u7afl3	266	37	at	at	IN
cord-342936-43u7afl3	266	38	much	much	RB
cord-342936-43u7afl3	266	39	higher	high	JJR
cord-342936-43u7afl3	266	40	levels	level	NNS
cord-342936-43u7afl3	266	41	than	than	IN
cord-342936-43u7afl3	266	42	wild	wild	JJ
cord-342936-43u7afl3	266	43	-	-	HYPH
cord-342936-43u7afl3	266	44	type	type	NN
cord-342936-43u7afl3	266	45	virus	virus	NN
cord-342936-43u7afl3	266	46	does	do	VBZ
cord-342936-43u7afl3	266	47	,	,	,
cord-342936-43u7afl3	266	48	which	which	WDT
cord-342936-43u7afl3	266	49	may	may	MD
cord-342936-43u7afl3	266	50	provide	provide	VB
cord-342936-43u7afl3	266	51	a	a	DT
cord-342936-43u7afl3	266	52	tool	tool	NN
cord-342936-43u7afl3	266	53	for	for	IN
cord-342936-43u7afl3	266	54	novel	novel	JJ
cord-342936-43u7afl3	266	55	vaccine	vaccine	NN
cord-342936-43u7afl3	266	56	immunogens	immunogens	NNP
cord-342936-43u7afl3	266	57	.	.	.
cord-342936-43u7afl3	267	1	Specific	specific	JJ
cord-342936-43u7afl3	267	2	N	n	CD
cord-342936-43u7afl3	267	3	-	-	HYPH
cord-342936-43u7afl3	267	4	linked	link	VBN
cord-342936-43u7afl3	267	5	glycosylation	glycosylation	NN
cord-342936-43u7afl3	267	6	modifications	modification	NNS
cord-342936-43u7afl3	267	7	in	in	IN
cord-342936-43u7afl3	267	8	the	the	DT
cord-342936-43u7afl3	267	9	envelope	envelope	NN
cord-342936-43u7afl3	267	10	V1	V1	VBZ
cord-342936-43u7afl3	267	11	domain	domain	NN
cord-342936-43u7afl3	267	12	of	of	IN
cord-342936-43u7afl3	267	13	SIV	SIV	NNP
cord-342936-43u7afl3	267	14	or	or	CC
cord-342936-43u7afl3	267	15	in	in	IN
cord-342936-43u7afl3	267	16	a	a	DT
cord-342936-43u7afl3	267	17	SIV	SIV	NNP
cord-342936-43u7afl3	267	18	-	-	HYPH
cord-342936-43u7afl3	267	19	HIV	HIV	NNP
cord-342936-43u7afl3	267	20	hybrid	hybrid	NN
cord-342936-43u7afl3	267	21	variant	variant	NN
cord-342936-43u7afl3	267	22	have	have	VBP
cord-342936-43u7afl3	267	23	also	also	RB
cord-342936-43u7afl3	267	24	been	be	VBN
cord-342936-43u7afl3	267	25	shown	show	VBN
cord-342936-43u7afl3	267	26	to	to	TO
cord-342936-43u7afl3	267	27	evolve	evolve	VB
cord-342936-43u7afl3	267	28	in	in	IN
cord-342936-43u7afl3	267	29	the	the	DT
cord-342936-43u7afl3	267	30	host	host	NN
cord-342936-43u7afl3	267	31	and	and	CC
cord-342936-43u7afl3	267	32	alter	alter	VB
cord-342936-43u7afl3	267	33	recognition	recognition	NN
cord-342936-43u7afl3	267	34	by	by	IN
cord-342936-43u7afl3	267	35	neutralizing	neutralize	VBG
cord-342936-43u7afl3	267	36	antibodies	antibody	NNS
cord-342936-43u7afl3	267	37	91	91	CD
cord-342936-43u7afl3	267	38	,	,	,
cord-342936-43u7afl3	267	39	92	92	CD
cord-342936-43u7afl3	267	40	.	.	.
cord-342936-43u7afl3	268	1	Studies	study	NNS
cord-342936-43u7afl3	268	2	with	with	IN
cord-342936-43u7afl3	268	3	SIVmac239	SIVmac239	NNP
cord-342936-43u7afl3	268	4	,	,	,
cord-342936-43u7afl3	268	5	which	which	WDT
cord-342936-43u7afl3	268	6	is	be	VBZ
cord-342936-43u7afl3	268	7	highly	highly	RB
cord-342936-43u7afl3	268	8	resistant	resistant	JJ
cord-342936-43u7afl3	268	9	to	to	IN
cord-342936-43u7afl3	268	10	neutralization	neutralization	NN
cord-342936-43u7afl3	268	11	by	by	IN
cord-342936-43u7afl3	268	12	polyclonal	polyclonal	JJ
cord-342936-43u7afl3	268	13	antisera	antisera	NN
cord-342936-43u7afl3	268	14	or	or	CC
cord-342936-43u7afl3	268	15	monoclonal	monoclonal	JJ
cord-342936-43u7afl3	268	16	antibodies	antibody	NNS
cord-342936-43u7afl3	268	17	,	,	,
cord-342936-43u7afl3	268	18	have	have	VBP
cord-342936-43u7afl3	268	19	shown	show	VBN
cord-342936-43u7afl3	268	20	that	that	IN
cord-342936-43u7afl3	268	21	elimination	elimination	NN
cord-342936-43u7afl3	268	22	of	of	IN
cord-342936-43u7afl3	268	23	N	n	CD
cord-342936-43u7afl3	268	24	-	-	HYPH
cord-342936-43u7afl3	268	25	glycan	glycan	NN
cord-342936-43u7afl3	268	26	attachment	attachment	NN
cord-342936-43u7afl3	268	27	sites	site	NNS
cord-342936-43u7afl3	268	28	in	in	IN
cord-342936-43u7afl3	268	29	the	the	DT
cord-342936-43u7afl3	268	30	envelope	envelope	NN
cord-342936-43u7afl3	269	1	gp120	gp120	NNP
cord-342936-43u7afl3	269	2	results	result	NNS
cord-342936-43u7afl3	269	3	in	in	IN
cord-342936-43u7afl3	269	4	a	a	DT
cord-342936-43u7afl3	269	5	dramatically	dramatically	RB
cord-342936-43u7afl3	269	6	increased	increase	VBN
cord-342936-43u7afl3	269	7	sensitivity	sensitivity	NN
cord-342936-43u7afl3	269	8	to	to	IN
cord-342936-43u7afl3	269	9	neutralization	neutralization	NN
cord-342936-43u7afl3	269	10	by	by	IN
cord-342936-43u7afl3	269	11	monoclonal	monoclonal	JJ
cord-342936-43u7afl3	269	12	antibodies	antibody	NNS
cord-342936-43u7afl3	269	13	93	93	CD
cord-342936-43u7afl3	269	14	.	.	.
cord-342936-43u7afl3	270	1	Importantly	importantly	RB
cord-342936-43u7afl3	270	2	,	,	,
cord-342936-43u7afl3	270	3	removal	removal	NN
cord-342936-43u7afl3	270	4	of	of	IN
cord-342936-43u7afl3	270	5	specific	specific	JJ
cord-342936-43u7afl3	270	6	N	n	CD
cord-342936-43u7afl3	270	7	-	-	HYPH
cord-342936-43u7afl3	270	8	glycans	glycan	NNS
cord-342936-43u7afl3	270	9	from	from	IN
cord-342936-43u7afl3	270	10	V1	V1	NNPS
cord-342936-43u7afl3	270	11	and	and	CC
cord-342936-43u7afl3	270	12	V2	v2	NN
cord-342936-43u7afl3	270	13	led	lead	VBD
cord-342936-43u7afl3	270	14	to	to	IN
cord-342936-43u7afl3	270	15	an	an	DT
cord-342936-43u7afl3	270	16	increase	increase	NN
cord-342936-43u7afl3	270	17	in	in	IN
cord-342936-43u7afl3	270	18	sensitivity	sensitivity	NN
cord-342936-43u7afl3	270	19	to	to	IN
cord-342936-43u7afl3	270	20	neutralization	neutralization	NN
cord-342936-43u7afl3	270	21	by	by	IN
cord-342936-43u7afl3	270	22	antibodies	antibody	NNS
cord-342936-43u7afl3	270	23	recognizing	recognize	VBG
cord-342936-43u7afl3	270	24	epitopes	epitope	NNS
cord-342936-43u7afl3	270	25	from	from	IN
cord-342936-43u7afl3	270	26	both	both	DT
cord-342936-43u7afl3	270	27	within	within	IN
cord-342936-43u7afl3	270	28	and	and	CC
cord-342936-43u7afl3	270	29	outside	outside	IN
cord-342936-43u7afl3	270	30	the	the	DT
cord-342936-43u7afl3	270	31	V1-V2	v1-v2	NN
cord-342936-43u7afl3	270	32	sequence	sequence	NN
cord-342936-43u7afl3	270	33	.	.	.
cord-342936-43u7afl3	271	1	Indeed	indeed	RB
cord-342936-43u7afl3	271	2	,	,	,
cord-342936-43u7afl3	271	3	mutations	mutation	NNS
cord-342936-43u7afl3	271	4	in	in	IN
cord-342936-43u7afl3	271	5	V1	v1	NN
cord-342936-43u7afl3	271	6	not	not	RB
cord-342936-43u7afl3	271	7	only	only	RB
cord-342936-43u7afl3	271	8	resulted	result	VBN
cord-342936-43u7afl3	271	9	in	in	IN
cord-342936-43u7afl3	271	10	an	an	DT
cord-342936-43u7afl3	271	11	increased	increase	VBN
cord-342936-43u7afl3	271	12	antibody	antibody	NN
cord-342936-43u7afl3	271	13	recognition	recognition	NN
cord-342936-43u7afl3	271	14	to	to	IN
cord-342936-43u7afl3	271	15	epitopes	epitope	NNS
cord-342936-43u7afl3	271	16	in	in	IN
cord-342936-43u7afl3	271	17	V1	v1	NN
cord-342936-43u7afl3	271	18	,	,	,
cord-342936-43u7afl3	271	19	but	but	CC
cord-342936-43u7afl3	271	20	also	also	RB
cord-342936-43u7afl3	271	21	in	in	IN
cord-342936-43u7afl3	271	22	a	a	DT
cord-342936-43u7afl3	271	23	redirection	redirection	NN
cord-342936-43u7afl3	271	24	of	of	IN
cord-342936-43u7afl3	271	25	antibody	antibody	NN
cord-342936-43u7afl3	271	26	responses	response	NNS
cord-342936-43u7afl3	271	27	to	to	IN
cord-342936-43u7afl3	271	28	the	the	DT
cord-342936-43u7afl3	271	29	V3	V3	NNP
cord-342936-43u7afl3	271	30	loop	loop	NN
cord-342936-43u7afl3	271	31	,	,	,
cord-342936-43u7afl3	271	32	which	which	WDT
cord-342936-43u7afl3	271	33	is	be	VBZ
cord-342936-43u7afl3	271	34	distant	distant	JJ
cord-342936-43u7afl3	271	35	in	in	IN
cord-342936-43u7afl3	271	36	the	the	DT
cord-342936-43u7afl3	271	37	linear	linear	JJ
cord-342936-43u7afl3	271	38	polypeptide	polypeptide	NN
cord-342936-43u7afl3	271	39	sequence	sequence	NN
cord-342936-43u7afl3	271	40	94	94	CD
cord-342936-43u7afl3	271	41	.	.	.
cord-342936-43u7afl3	272	1	When	when	WRB
cord-342936-43u7afl3	272	2	Rhesus	Rhesus	NNP
cord-342936-43u7afl3	272	3	monkeys	monkey	NNS
cord-342936-43u7afl3	272	4	were	be	VBD
cord-342936-43u7afl3	272	5	infected	infect	VBN
cord-342936-43u7afl3	272	6	with	with	IN
cord-342936-43u7afl3	272	7	mutant	mutant	JJ
cord-342936-43u7afl3	272	8	SIV	SIV	NNP
cord-342936-43u7afl3	272	9	strains	strain	NNS
cord-342936-43u7afl3	272	10	that	that	WDT
cord-342936-43u7afl3	272	11	were	be	VBD
cord-342936-43u7afl3	272	12	lacking	lack	VBG
cord-342936-43u7afl3	272	13	in	in	IN
cord-342936-43u7afl3	272	14	combinations	combination	NNS
cord-342936-43u7afl3	272	15	of	of	IN
cord-342936-43u7afl3	272	16	the	the	DT
cord-342936-43u7afl3	272	17	two	two	CD
cord-342936-43u7afl3	272	18	N	n	CD
cord-342936-43u7afl3	272	19	-	-	HYPH
cord-342936-43u7afl3	272	20	glycosylation	glycosylation	NN
cord-342936-43u7afl3	272	21	sites	site	NNS
cord-342936-43u7afl3	272	22	in	in	IN
cord-342936-43u7afl3	272	23	gp120	gp120	NNP
cord-342936-43u7afl3	272	24	,	,	,
cord-342936-43u7afl3	272	25	a	a	DT
cord-342936-43u7afl3	272	26	marked	marked	JJ
cord-342936-43u7afl3	272	27	increase	increase	NN
cord-342936-43u7afl3	272	28	in	in	IN
cord-342936-43u7afl3	272	29	antibody	antibody	NN
cord-342936-43u7afl3	272	30	binding	bind	VBG
cord-342936-43u7afl3	272	31	to	to	IN
cord-342936-43u7afl3	272	32	specific	specific	JJ
cord-342936-43u7afl3	272	33	peptides	peptide	NNS
cord-342936-43u7afl3	272	34	derived	derive	VBN
cord-342936-43u7afl3	272	35	from	from	IN
cord-342936-43u7afl3	272	36	the	the	DT
cord-342936-43u7afl3	272	37	glycan	glycan	NN
cord-342936-43u7afl3	272	38	-	-	HYPH
cord-342936-43u7afl3	272	39	deleted	delete	VBN
cord-342936-43u7afl3	272	40	regions	region	NNS
cord-342936-43u7afl3	272	41	was	be	VBD
cord-342936-43u7afl3	272	42	observed	observe	VBN
cord-342936-43u7afl3	272	43	,	,	,
cord-342936-43u7afl3	272	44	which	which	WDT
cord-342936-43u7afl3	272	45	resulted	result	VBD
cord-342936-43u7afl3	272	46	in	in	IN
cord-342936-43u7afl3	272	47	an	an	DT
cord-342936-43u7afl3	272	48	increased	increase	VBN
cord-342936-43u7afl3	272	49	neutralizing	neutralize	VBG
cord-342936-43u7afl3	272	50	activity	activity	NN
cord-342936-43u7afl3	272	51	.	.	.
cord-342936-43u7afl3	273	1	These	these	DT
cord-342936-43u7afl3	273	2	results	result	NNS
cord-342936-43u7afl3	273	3	convincingly	convincingly	RB
cord-342936-43u7afl3	273	4	demonstrated	demonstrate	VBD
cord-342936-43u7afl3	273	5	that	that	IN
cord-342936-43u7afl3	273	6	the	the	DT
cord-342936-43u7afl3	273	7	presence	presence	NN
cord-342936-43u7afl3	273	8	of	of	IN
cord-342936-43u7afl3	273	9	N	n	NN
cord-342936-43u7afl3	273	10	-	-	HYPH
cord-342936-43u7afl3	273	11	glycans	glycan	NNS
cord-342936-43u7afl3	273	12	limits	limit	VBZ
cord-342936-43u7afl3	273	13	the	the	DT
cord-342936-43u7afl3	273	14	neutralizing	neutralize	VBG
cord-342936-43u7afl3	273	15	antibody	antibody	NN
cord-342936-43u7afl3	273	16	response	response	NN
cord-342936-43u7afl3	273	17	to	to	IN
cord-342936-43u7afl3	273	18	SIV	SIV	NNP
cord-342936-43u7afl3	273	19	,	,	,
cord-342936-43u7afl3	273	20	and	and	CC
cord-342936-43u7afl3	273	21	helps	help	VBZ
cord-342936-43u7afl3	273	22	shield	shield	VB
cord-342936-43u7afl3	273	23	the	the	DT
cord-342936-43u7afl3	273	24	virus	virus	NN
cord-342936-43u7afl3	273	25	from	from	IN
cord-342936-43u7afl3	273	26	immune	immune	JJ
cord-342936-43u7afl3	273	27	recognition	recognition	NN
cord-342936-43u7afl3	273	28	95	95	CD
cord-342936-43u7afl3	273	29	.	.	.
cord-342936-43u7afl3	274	1	These	these	DT
cord-342936-43u7afl3	274	2	results	result	NNS
cord-342936-43u7afl3	274	3	also	also	RB
cord-342936-43u7afl3	274	4	illustrate	illustrate	VBP
cord-342936-43u7afl3	274	5	that	that	DT
cord-342936-43u7afl3	274	6	deletion	deletion	NN
cord-342936-43u7afl3	274	7	of	of	IN
cord-342936-43u7afl3	274	8	as	as	RB
cord-342936-43u7afl3	274	9	few	few	JJ
cord-342936-43u7afl3	274	10	as	as	IN
cord-342936-43u7afl3	274	11	two	two	CD
cord-342936-43u7afl3	274	12	glycosylation	glycosylation	NN
cord-342936-43u7afl3	274	13	sites	site	NNS
cord-342936-43u7afl3	274	14	in	in	IN
cord-342936-43u7afl3	274	15	the	the	DT
cord-342936-43u7afl3	274	16	viral	viral	JJ
cord-342936-43u7afl3	274	17	env	env	NN
cord-342936-43u7afl3	274	18	gene	gene	NN
cord-342936-43u7afl3	274	19	is	be	VBZ
cord-342936-43u7afl3	274	20	sufficient	sufficient	JJ
cord-342936-43u7afl3	274	21	to	to	TO
cord-342936-43u7afl3	274	22	trigger	trigger	VB
cord-342936-43u7afl3	274	23	a	a	DT
cord-342936-43u7afl3	274	24	significant	significant	JJ
cord-342936-43u7afl3	274	25	neutralizing	neutralize	VBG
cord-342936-43u7afl3	274	26	antibody	antibody	NN
cord-342936-43u7afl3	274	27	response	response	NN
cord-342936-43u7afl3	274	28	.	.	.
cord-342936-43u7afl3	275	1	Blay	Blay	NNP
cord-342936-43u7afl3	275	2	et	et	NNP
cord-342936-43u7afl3	275	3	al	al	NNP
cord-342936-43u7afl3	275	4	.	.	.
cord-342936-43u7afl3	276	1	96	96	CD
cord-342936-43u7afl3	276	2	showed	show	VBD
cord-342936-43u7afl3	276	3	that	that	IN
cord-342936-43u7afl3	276	4	a	a	DT
cord-342936-43u7afl3	276	5	significant	significant	JJ
cord-342936-43u7afl3	276	6	divergence	divergence	NN
cord-342936-43u7afl3	276	7	in	in	IN
cord-342936-43u7afl3	276	8	the	the	DT
cord-342936-43u7afl3	276	9	Env	Env	NNP
cord-342936-43u7afl3	276	10	proteins	protein	NNS
cord-342936-43u7afl3	276	11	occurs	occur	VBZ
cord-342936-43u7afl3	276	12	over	over	IN
cord-342936-43u7afl3	276	13	time	time	NN
cord-342936-43u7afl3	276	14	in	in	IN
cord-342936-43u7afl3	276	15	macaques	macaque	NNS
cord-342936-43u7afl3	276	16	infected	infect	VBN
cord-342936-43u7afl3	276	17	with	with	IN
cord-342936-43u7afl3	276	18	the	the	DT
cord-342936-43u7afl3	276	19	SIV	SIV	NNP
cord-342936-43u7afl3	277	1	strain	strain	VB
cord-342936-43u7afl3	277	2	SHIV-89.6P	SHIV-89.6P	NNP
cord-342936-43u7afl3	278	1	(	(	-LRB-
cord-342936-43u7afl3	278	2	containing	contain	VBG
cord-342936-43u7afl3	278	3	HIV	HIV	NNP
cord-342936-43u7afl3	278	4	env	env	NN
cord-342936-43u7afl3	278	5	subtype	subtype	NN
cord-342936-43u7afl3	278	6	B	b	NN
cord-342936-43u7afl3	278	7	in	in	IN
cord-342936-43u7afl3	278	8	a	a	DT
cord-342936-43u7afl3	278	9	SIV	SIV	NNP
cord-342936-43u7afl3	278	10	background	background	NN
cord-342936-43u7afl3	278	11	)	)	-RRB-
cord-342936-43u7afl3	278	12	.	.	.
cord-342936-43u7afl3	279	1	Importantly	importantly	RB
cord-342936-43u7afl3	279	2	,	,	,
cord-342936-43u7afl3	279	3	the	the	DT
cord-342936-43u7afl3	279	4	total	total	JJ
cord-342936-43u7afl3	279	5	number	number	NN
cord-342936-43u7afl3	279	6	of	of	IN
cord-342936-43u7afl3	279	7	potential	potential	JJ
cord-342936-43u7afl3	279	8	N	n	CD
cord-342936-43u7afl3	279	9	-	-	HYPH
cord-342936-43u7afl3	279	10	glycosylation	glycosylation	NN
cord-342936-43u7afl3	279	11	sites	site	NNS
cord-342936-43u7afl3	279	12	did	do	VBD
cord-342936-43u7afl3	279	13	not	not	RB
cord-342936-43u7afl3	279	14	increase	increase	VB
cord-342936-43u7afl3	279	15	over	over	IN
cord-342936-43u7afl3	279	16	time	time	NN
cord-342936-43u7afl3	279	17	,	,	,
cord-342936-43u7afl3	279	18	and	and	CC
cord-342936-43u7afl3	279	19	there	there	EX
cord-342936-43u7afl3	279	20	was	be	VBD
cord-342936-43u7afl3	279	21	a	a	DT
cord-342936-43u7afl3	279	22	remarkable	remarkable	JJ
cord-342936-43u7afl3	279	23	degree	degree	NN
cord-342936-43u7afl3	279	24	of	of	IN
cord-342936-43u7afl3	279	25	conservation	conservation	NN
cord-342936-43u7afl3	279	26	in	in	IN
cord-342936-43u7afl3	279	27	patterns	pattern	NNS
cord-342936-43u7afl3	279	28	of	of	IN
cord-342936-43u7afl3	279	29	change	change	NN
cord-342936-43u7afl3	279	30	in	in	IN
cord-342936-43u7afl3	279	31	Env	Env	NNP
cord-342936-43u7afl3	279	32	glycans	glycan	NNS
cord-342936-43u7afl3	279	33	.	.	.
cord-342936-43u7afl3	280	1	These	these	DT
cord-342936-43u7afl3	280	2	findings	finding	NNS
cord-342936-43u7afl3	280	3	suggest	suggest	VBP
cord-342936-43u7afl3	280	4	that	that	IN
cord-342936-43u7afl3	280	5	the	the	DT
cord-342936-43u7afl3	280	6	configuration	configuration	NN
cord-342936-43u7afl3	280	7	of	of	IN
cord-342936-43u7afl3	280	8	the	the	DT
cord-342936-43u7afl3	280	9	glycan	glycan	NN
cord-342936-43u7afl3	280	10	shield	shield	NN
cord-342936-43u7afl3	280	11	is	be	VBZ
cord-342936-43u7afl3	280	12	under	under	IN
cord-342936-43u7afl3	280	13	considerable	considerable	JJ
cord-342936-43u7afl3	280	14	constraints	constraint	NNS
cord-342936-43u7afl3	280	15	,	,	,
cord-342936-43u7afl3	280	16	which	which	WDT
cord-342936-43u7afl3	280	17	is	be	VBZ
cord-342936-43u7afl3	280	18	in	in	IN
cord-342936-43u7afl3	280	19	agreement	agreement	NN
cord-342936-43u7afl3	280	20	with	with	IN
cord-342936-43u7afl3	280	21	the	the	DT
cord-342936-43u7afl3	280	22	findings	finding	NNS
cord-342936-43u7afl3	280	23	of	of	IN
cord-342936-43u7afl3	280	24	Poon	Poon	NNP
cord-342936-43u7afl3	280	25	et	et	NNP
cord-342936-43u7afl3	280	26	al	al	NNP
cord-342936-43u7afl3	280	27	.	.	.
cord-342936-43u7afl3	281	1	97	97	CD
cord-342936-43u7afl3	281	2	,	,	,
cord-342936-43u7afl3	281	3	who	who	WP
cord-342936-43u7afl3	281	4	showed	show	VBD
cord-342936-43u7afl3	281	5	that	that	IN
cord-342936-43u7afl3	281	6	negative	negative	JJ
cord-342936-43u7afl3	281	7	(	(	-LRB-
cord-342936-43u7afl3	281	8	exclusive	exclusive	JJ
cord-342936-43u7afl3	281	9	)	)	-RRB-
cord-342936-43u7afl3	281	10	interactions	interaction	NNS
cord-342936-43u7afl3	281	11	occur	occur	VBP
cord-342936-43u7afl3	281	12	more	more	RBR
cord-342936-43u7afl3	281	13	often	often	RB
cord-342936-43u7afl3	281	14	between	between	IN
cord-342936-43u7afl3	281	15	co	co	JJ
cord-342936-43u7afl3	281	16	-	-	JJ
cord-342936-43u7afl3	281	17	localized	localize	VBN
cord-342936-43u7afl3	281	18	glycans	glycan	NNS
cord-342936-43u7afl3	281	19	,	,	,
cord-342936-43u7afl3	281	20	whereas	whereas	IN
cord-342936-43u7afl3	281	21	positive	positive	JJ
cord-342936-43u7afl3	281	22	(	(	-LRB-
cord-342936-43u7afl3	281	23	inclusive	inclusive	JJ
cord-342936-43u7afl3	281	24	)	)	-RRB-
cord-342936-43u7afl3	281	25	interactions	interaction	NNS
cord-342936-43u7afl3	281	26	are	be	VBP
cord-342936-43u7afl3	281	27	restricted	restrict	VBN
cord-342936-43u7afl3	281	28	to	to	IN
cord-342936-43u7afl3	281	29	more	more	RBR
cord-342936-43u7afl3	281	30	distant	distant	JJ
cord-342936-43u7afl3	281	31	glycans	glycan	NNS
cord-342936-43u7afl3	281	32	.	.	.
cord-342936-43u7afl3	282	1	These	these	DT
cord-342936-43u7afl3	282	2	data	datum	NNS
cord-342936-43u7afl3	282	3	imply	imply	VBP
cord-342936-43u7afl3	282	4	that	that	IN
cord-342936-43u7afl3	282	5	the	the	DT
cord-342936-43u7afl3	282	6	adaptive	adaptive	JJ
cord-342936-43u7afl3	282	7	repertoire	repertoire	NN
cord-342936-43u7afl3	282	8	of	of	IN
cord-342936-43u7afl3	282	9	alternative	alternative	JJ
cord-342936-43u7afl3	282	10	configurations	configuration	NNS
cord-342936-43u7afl3	282	11	in	in	IN
cord-342936-43u7afl3	282	12	the	the	DT
cord-342936-43u7afl3	282	13	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	282	14	glycan	glycan	NN
cord-342936-43u7afl3	282	15	shield	shield	NN
cord-342936-43u7afl3	282	16	is	be	VBZ
cord-342936-43u7afl3	282	17	limited	limit	VBN
cord-342936-43u7afl3	282	18	by	by	IN
cord-342936-43u7afl3	282	19	functional	functional	JJ
cord-342936-43u7afl3	282	20	interactions	interaction	NNS
cord-342936-43u7afl3	282	21	between	between	IN
cord-342936-43u7afl3	282	22	the	the	DT
cord-342936-43u7afl3	282	23	N	n	CD
cord-342936-43u7afl3	282	24	-	-	HYPH
cord-342936-43u7afl3	282	25	glycans	glycan	NNS
cord-342936-43u7afl3	282	26	97	97	CD
cord-342936-43u7afl3	282	27	.	.	.
cord-342936-43u7afl3	283	1	Therefore	therefore	RB
cord-342936-43u7afl3	283	2	,	,	,
cord-342936-43u7afl3	283	3	it	-PRON-	PRP
cord-342936-43u7afl3	283	4	seems	seem	VBZ
cord-342936-43u7afl3	283	5	likely	likely	JJ
cord-342936-43u7afl3	283	6	that	that	IN
cord-342936-43u7afl3	283	7	CBA	CBA	NNP
cord-342936-43u7afl3	283	8	exposure	exposure	NN
cord-342936-43u7afl3	283	9	to	to	IN
cord-342936-43u7afl3	283	10	SIV	SIV	NNP
cord-342936-43u7afl3	283	11	or	or	CC
cord-342936-43u7afl3	283	12	HIV	HIV	NNP
cord-342936-43u7afl3	283	13	strains	strain	NNS
cord-342936-43u7afl3	283	14	would	would	MD
cord-342936-43u7afl3	283	15	seriously	seriously	RB
cord-342936-43u7afl3	283	16	compromise	compromise	VB
cord-342936-43u7afl3	283	17	these	these	DT
cord-342936-43u7afl3	283	18	constraints	constraint	NNS
cord-342936-43u7afl3	283	19	,	,	,
cord-342936-43u7afl3	283	20	by	by	IN
cord-342936-43u7afl3	283	21	forcing	force	VBG
cord-342936-43u7afl3	283	22	the	the	DT
cord-342936-43u7afl3	283	23	AIDS	AIDS	NNP
cord-342936-43u7afl3	283	24	,	,	,
cord-342936-43u7afl3	283	25	acquired	acquire	VBN
cord-342936-43u7afl3	283	26	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	283	27	syndrome	syndrome	NN
cord-342936-43u7afl3	283	28	;	;	:
cord-342936-43u7afl3	283	29	DC	DC	NNP
cord-342936-43u7afl3	283	30	-	-	HYPH
cord-342936-43u7afl3	283	31	SIGN	sign	NN
cord-342936-43u7afl3	283	32	,	,	,
cord-342936-43u7afl3	283	33	dendritic	dendritic	JJ
cord-342936-43u7afl3	283	34	-	-	HYPH
cord-342936-43u7afl3	283	35	cell	cell	NN
cord-342936-43u7afl3	283	36	-	-	HYPH
cord-342936-43u7afl3	283	37	specific	specific	JJ
cord-342936-43u7afl3	283	38	intercellular	intercellular	JJ
cord-342936-43u7afl3	283	39	adhesion	adhesion	NN
cord-342936-43u7afl3	283	40	molecule	molecule	NN
cord-342936-43u7afl3	283	41	3-grabbing	3-grabbing	CD
cord-342936-43u7afl3	283	42	non	non	JJ
cord-342936-43u7afl3	283	43	-	-	JJ
cord-342936-43u7afl3	283	44	integrin	integrin	JJ
cord-342936-43u7afl3	283	45	;	;	:
cord-342936-43u7afl3	283	46	HCV	HCV	NNP
cord-342936-43u7afl3	283	47	,	,	,
cord-342936-43u7afl3	283	48	human	human	JJ
cord-342936-43u7afl3	283	49	hepatitis	hepatitis	NN
cord-342936-43u7afl3	283	50	C	C	NNP
cord-342936-43u7afl3	283	51	virus	virus	NN
cord-342936-43u7afl3	283	52	;	;	:
cord-342936-43u7afl3	283	53	L	l	NN
cord-342936-43u7afl3	283	54	-	-	HYPH
cord-342936-43u7afl3	283	55	SIGN	sign	NN
cord-342936-43u7afl3	283	56	,	,	,
cord-342936-43u7afl3	283	57	liver	liver	NN
cord-342936-43u7afl3	283	58	/	/	SYM
cord-342936-43u7afl3	283	59	lymph	lymph	NN
cord-342936-43u7afl3	283	60	node	node	NN
cord-342936-43u7afl3	283	61	-	-	:
cord-342936-43u7afl3	283	62	SIGN	sign	NN
cord-342936-43u7afl3	283	63	;	;	:
cord-342936-43u7afl3	283	64	SARS	SARS	NNP
cord-342936-43u7afl3	283	65	,	,	,
cord-342936-43u7afl3	283	66	severe	severe	JJ
cord-342936-43u7afl3	283	67	acute	acute	JJ
cord-342936-43u7afl3	283	68	respiratory	respiratory	JJ
cord-342936-43u7afl3	283	69	syndrome	syndrome	NN
cord-342936-43u7afl3	283	70	.	.	.
cord-342936-43u7afl3	284	1	virus	virus	NN
cord-342936-43u7afl3	284	2	to	to	TO
cord-342936-43u7afl3	284	3	progressively	progressively	RB
cord-342936-43u7afl3	284	4	delete	delete	VB
cord-342936-43u7afl3	284	5	envelope	envelope	NN
cord-342936-43u7afl3	284	6	glycans	glycan	NNS
cord-342936-43u7afl3	284	7	and	and	CC
cord-342936-43u7afl3	284	8	allowing	allow	VBG
cord-342936-43u7afl3	284	9	the	the	DT
cord-342936-43u7afl3	284	10	immune	immune	JJ
cord-342936-43u7afl3	284	11	system	system	NN
cord-342936-43u7afl3	284	12	to	to	TO
cord-342936-43u7afl3	284	13	become	become	VB
cord-342936-43u7afl3	284	14	actively	actively	RB
cord-342936-43u7afl3	284	15	involved	involve	VBN
cord-342936-43u7afl3	284	16	in	in	IN
cord-342936-43u7afl3	284	17	inhibiting	inhibit	VBG
cord-342936-43u7afl3	284	18	the	the	DT
cord-342936-43u7afl3	284	19	virus	virus	NN
cord-342936-43u7afl3	284	20	infection	infection	NN
cord-342936-43u7afl3	284	21	.	.	.
cord-342936-43u7afl3	285	1	In	in	IN
cord-342936-43u7afl3	285	2	conclusion	conclusion	NN
cord-342936-43u7afl3	285	3	,	,	,
cord-342936-43u7afl3	285	4	much	much	JJ
cord-342936-43u7afl3	285	5	data	datum	NNS
cord-342936-43u7afl3	285	6	are	be	VBP
cord-342936-43u7afl3	285	7	currently	currently	RB
cord-342936-43u7afl3	285	8	available	available	JJ
cord-342936-43u7afl3	285	9	to	to	TO
cord-342936-43u7afl3	285	10	show	show	VB
cord-342936-43u7afl3	285	11	that	that	IN
cord-342936-43u7afl3	285	12	glycan	glycan	NN
cord-342936-43u7afl3	285	13	deletions	deletion	NNS
cord-342936-43u7afl3	285	14	in	in	IN
cord-342936-43u7afl3	285	15	the	the	DT
cord-342936-43u7afl3	285	16	viral	viral	JJ
cord-342936-43u7afl3	285	17	envelope	envelope	NN
cord-342936-43u7afl3	285	18	uncover	uncover	VBP
cord-342936-43u7afl3	285	19	immunogenic	immunogenic	JJ
cord-342936-43u7afl3	285	20	epitopes	epitope	NNS
cord-342936-43u7afl3	285	21	that	that	WDT
cord-342936-43u7afl3	285	22	result	result	VBP
cord-342936-43u7afl3	285	23	in	in	IN
cord-342936-43u7afl3	285	24	an	an	DT
cord-342936-43u7afl3	285	25	increased	increase	VBN
cord-342936-43u7afl3	285	26	neutralization	neutralization	NN
cord-342936-43u7afl3	285	27	of	of	IN
cord-342936-43u7afl3	285	28	the	the	DT
cord-342936-43u7afl3	285	29	mutant	mutant	JJ
cord-342936-43u7afl3	285	30	virus	virus	NN
cord-342936-43u7afl3	285	31	.	.	.
cord-342936-43u7afl3	286	1	Pathogen	pathogen	NN
cord-342936-43u7afl3	286	2	susceptibility	susceptibility	NN
cord-342936-43u7afl3	286	3	to	to	IN
cord-342936-43u7afl3	286	4	CBA	CBA	NNP
cord-342936-43u7afl3	286	5	therapy	therapy	NN
cord-342936-43u7afl3	287	1	It	-PRON-	PRP
cord-342936-43u7afl3	287	2	has	have	VBZ
cord-342936-43u7afl3	287	3	been	be	VBN
cord-342936-43u7afl3	287	4	shown	show	VBN
cord-342936-43u7afl3	287	5	that	that	IN
cord-342936-43u7afl3	287	6	DC	DC	NNP
cord-342936-43u7afl3	287	7	-	-	HYPH
cord-342936-43u7afl3	287	8	SIGN	SIGN	NNP
cord-342936-43u7afl3	287	9	can	can	MD
cord-342936-43u7afl3	287	10	recognize	recognize	VB
cord-342936-43u7afl3	287	11	and	and	CC
cord-342936-43u7afl3	287	12	internalize	internalize	VB
cord-342936-43u7afl3	287	13	numerous	numerous	JJ
cord-342936-43u7afl3	287	14	other	other	JJ
cord-342936-43u7afl3	287	15	viruses	virus	NNS
cord-342936-43u7afl3	287	16	,	,	,
cord-342936-43u7afl3	287	17	bacteria	bacteria	NNS
cord-342936-43u7afl3	287	18	and	and	CC
cord-342936-43u7afl3	287	19	protozoa	protozoan	NNS
cord-342936-43u7afl3	287	20	in	in	IN
cord-342936-43u7afl3	287	21	addition	addition	NN
cord-342936-43u7afl3	287	22	to	to	IN
cord-342936-43u7afl3	287	23	HIV	HIV	NNP
cord-342936-43u7afl3	287	24	98	98	CD
cord-342936-43u7afl3	287	25	(	(	-LRB-
cord-342936-43u7afl3	287	26	TABLE	TABLE	NNP
cord-342936-43u7afl3	287	27	2	2	CD
cord-342936-43u7afl3	287	28	)	)	-RRB-
cord-342936-43u7afl3	287	29	.	.	.
cord-342936-43u7afl3	288	1	In	in	IN
cord-342936-43u7afl3	288	2	this	this	DT
cord-342936-43u7afl3	288	3	way	way	NN
cord-342936-43u7afl3	288	4	,	,	,
cord-342936-43u7afl3	288	5	DC	DC	NNP
cord-342936-43u7afl3	288	6	-	-	HYPH
cord-342936-43u7afl3	288	7	SIGN	SIGN	NNP
cord-342936-43u7afl3	288	8	can	can	MD
cord-342936-43u7afl3	288	9	be	be	VB
cord-342936-43u7afl3	288	10	considered	consider	VBN
cord-342936-43u7afl3	288	11	to	to	TO
cord-342936-43u7afl3	288	12	be	be	VB
cord-342936-43u7afl3	288	13	a	a	DT
cord-342936-43u7afl3	288	14	universal	universal	JJ
cord-342936-43u7afl3	288	15	pathogen	pathogen	NN
cord-342936-43u7afl3	288	16	receptor	receptor	NN
cord-342936-43u7afl3	288	17	.	.	.
cord-342936-43u7afl3	289	1	Indeed	indeed	RB
cord-342936-43u7afl3	289	2	,	,	,
cord-342936-43u7afl3	289	3	the	the	DT
cord-342936-43u7afl3	289	4	recent	recent	JJ
cord-342936-43u7afl3	289	5	identification	identification	NN
cord-342936-43u7afl3	289	6	of	of	IN
cord-342936-43u7afl3	289	7	the	the	DT
cord-342936-43u7afl3	289	8	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	289	9	specificity	specificity	NN
cord-342936-43u7afl3	289	10	of	of	IN
cord-342936-43u7afl3	289	11	the	the	DT
cord-342936-43u7afl3	289	12	SIGN	sign	NN
cord-342936-43u7afl3	289	13	molecules	molecule	NNS
cord-342936-43u7afl3	289	14	for	for	IN
cord-342936-43u7afl3	289	15	high	high	JJ
cord-342936-43u7afl3	289	16	-	-	HYPH
cord-342936-43u7afl3	289	17	mannose	mannose	NN
cord-342936-43u7afl3	289	18	-	-	HYPH
cord-342936-43u7afl3	289	19	and	and	CC
cord-342936-43u7afl3	289	20	/	/	SYM
cord-342936-43u7afl3	289	21	or	or	CC
cord-342936-43u7afl3	289	22	fucose	fucose	NN
cord-342936-43u7afl3	289	23	-	-	HYPH
cord-342936-43u7afl3	289	24	containing	contain	VBG
cord-342936-43u7afl3	289	25	glycans	glycan	NNS
cord-342936-43u7afl3	289	26	has	have	VBZ
cord-342936-43u7afl3	289	27	led	lead	VBN
cord-342936-43u7afl3	289	28	to	to	IN
cord-342936-43u7afl3	289	29	the	the	DT
cord-342936-43u7afl3	289	30	identification	identification	NN
cord-342936-43u7afl3	289	31	of	of	IN
cord-342936-43u7afl3	289	32	various	various	JJ
cord-342936-43u7afl3	289	33	pathogens	pathogen	NNS
cord-342936-43u7afl3	289	34	that	that	WDT
cord-342936-43u7afl3	289	35	are	be	VBP
cord-342936-43u7afl3	289	36	recognized	recognize	VBN
cord-342936-43u7afl3	289	37	by	by	IN
cord-342936-43u7afl3	289	38	these	these	DT
cord-342936-43u7afl3	289	39	receptors	receptor	NNS
cord-342936-43u7afl3	289	40	(	(	-LRB-
cord-342936-43u7afl3	289	41	TABLE	TABLE	NNP
cord-342936-43u7afl3	289	42	1	1	CD
cord-342936-43u7afl3	289	43	)	)	-RRB-
cord-342936-43u7afl3	289	44	.	.	.
cord-342936-43u7afl3	290	1	DC	DC	NNP
cord-342936-43u7afl3	290	2	-	-	HYPH
cord-342936-43u7afl3	290	3	SIGN	sign	NN
cord-342936-43u7afl3	290	4	binds	bind	VBZ
cord-342936-43u7afl3	290	5	and	and	CC
cord-342936-43u7afl3	290	6	internalizes	internalize	VBZ
cord-342936-43u7afl3	290	7	Dengue	dengue	NN
cord-342936-43u7afl3	290	8	virus	virus	NN
cord-342936-43u7afl3	290	9	99	99	CD
cord-342936-43u7afl3	290	10	,	,	,
cord-342936-43u7afl3	290	11	human	human	JJ
cord-342936-43u7afl3	290	12	cytomegalovirus	cytomegalovirus	NNP
cord-342936-43u7afl3	290	13	100	100	CD
cord-342936-43u7afl3	290	14	,	,	,
cord-342936-43u7afl3	290	15	HCV	HCV	NNP
cord-342936-43u7afl3	290	16	101	101	CD
cord-342936-43u7afl3	290	17	and	and	CC
cord-342936-43u7afl3	290	18	Ebola	Ebola	NNP
cord-342936-43u7afl3	290	19	virus	virus	NN
cord-342936-43u7afl3	290	20	102	102	CD
cord-342936-43u7afl3	290	21	to	to	TO
cord-342936-43u7afl3	290	22	allow	allow	VB
cord-342936-43u7afl3	290	23	efficient	efficient	JJ
cord-342936-43u7afl3	290	24	trans	trans	JJ
cord-342936-43u7afl3	290	25	infection	infection	NN
cord-342936-43u7afl3	290	26	of	of	IN
cord-342936-43u7afl3	290	27	the	the	DT
cord-342936-43u7afl3	290	28	target	target	NN
cord-342936-43u7afl3	290	29	cells	cell	NNS
cord-342936-43u7afl3	290	30	.	.	.
cord-342936-43u7afl3	291	1	It	-PRON-	PRP
cord-342936-43u7afl3	291	2	is	be	VBZ
cord-342936-43u7afl3	291	3	also	also	RB
cord-342936-43u7afl3	291	4	well	well	RB
cord-342936-43u7afl3	291	5	documented	document	VBN
cord-342936-43u7afl3	291	6	that	that	IN
cord-342936-43u7afl3	291	7	HCV	HCV	NNP
cord-342936-43u7afl3	291	8	closely	closely	RB
cord-342936-43u7afl3	291	9	interacts	interact	VBZ
cord-342936-43u7afl3	291	10	with	with	IN
cord-342936-43u7afl3	291	11	both	both	DT
cord-342936-43u7afl3	291	12	DC	DC	NNP
cord-342936-43u7afl3	291	13	-	-	HYPH
cord-342936-43u7afl3	291	14	SIGN	sign	NN
cord-342936-43u7afl3	291	15	and	and	CC
cord-342936-43u7afl3	291	16	liver	liver	NN
cord-342936-43u7afl3	291	17	/	/	SYM
cord-342936-43u7afl3	291	18	lymph	lymph	NN
cord-342936-43u7afl3	291	19	node	node	NN
cord-342936-43u7afl3	291	20	(	(	-LRB-
cord-342936-43u7afl3	291	21	L)-SIGN	L)-SIGN	NNP
cord-342936-43u7afl3	291	22	,	,	,
cord-342936-43u7afl3	291	23	a	a	DT
cord-342936-43u7afl3	291	24	close	close	JJ
cord-342936-43u7afl3	291	25	homologue	homologue	NN
cord-342936-43u7afl3	291	26	of	of	IN
cord-342936-43u7afl3	291	27	DC	DC	NNP
cord-342936-43u7afl3	291	28	-	-	HYPH
cord-342936-43u7afl3	291	29	SIGN	SIGN	NNP
cord-342936-43u7afl3	291	30	that	that	WDT
cord-342936-43u7afl3	291	31	is	be	VBZ
cord-342936-43u7afl3	291	32	expressed	express	VBN
cord-342936-43u7afl3	291	33	on	on	IN
cord-342936-43u7afl3	291	34	specialized	specialized	JJ
cord-342936-43u7afl3	291	35	liver	liver	NN
cord-342936-43u7afl3	291	36	and	and	CC
cord-342936-43u7afl3	291	37	lymph	lymph	NN
cord-342936-43u7afl3	291	38	-	-	HYPH
cord-342936-43u7afl3	291	39	node	node	NN
cord-342936-43u7afl3	291	40	endothelial	endothelial	JJ
cord-342936-43u7afl3	291	41	cells	cell	NNS
cord-342936-43u7afl3	291	42	that	that	WDT
cord-342936-43u7afl3	291	43	have	have	VBP
cord-342936-43u7afl3	291	44	antigen	antigen	NN
cord-342936-43u7afl3	291	45	-	-	HYPH
cord-342936-43u7afl3	291	46	presenting	present	VBG
cord-342936-43u7afl3	291	47	capacity	capacity	NN
cord-342936-43u7afl3	291	48	98	98	CD
cord-342936-43u7afl3	291	49	.	.	.
cord-342936-43u7afl3	292	1	The	the	DT
cord-342936-43u7afl3	292	2	capture	capture	NN
cord-342936-43u7afl3	292	3	of	of	IN
cord-342936-43u7afl3	292	4	HCV	HCV	NNP
cord-342936-43u7afl3	292	5	by	by	IN
cord-342936-43u7afl3	292	6	the	the	DT
cord-342936-43u7afl3	292	7	SIGN	sign	NN
cord-342936-43u7afl3	292	8	-	-	HYPH
cord-342936-43u7afl3	292	9	positive	positive	JJ
cord-342936-43u7afl3	292	10	cells	cell	NNS
cord-342936-43u7afl3	292	11	,	,	,
cord-342936-43u7afl3	292	12	through	through	IN
cord-342936-43u7afl3	292	13	the	the	DT
cord-342936-43u7afl3	292	14	highly	highly	RB
cord-342936-43u7afl3	292	15	glycosylated	glycosylated	JJ
cord-342936-43u7afl3	292	16	(	(	-LRB-
cord-342936-43u7afl3	292	17	high	high	JJ
cord-342936-43u7afl3	292	18	-	-	HYPH
cord-342936-43u7afl3	292	19	mannose	mannose	NN
cord-342936-43u7afl3	292	20	type	type	NN
cord-342936-43u7afl3	292	21	)	)	-RRB-
cord-342936-43u7afl3	292	22	envelope	envelope	NN
cord-342936-43u7afl3	292	23	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	292	24	E2	E2	NNP
cord-342936-43u7afl3	292	25	,	,	,
cord-342936-43u7afl3	292	26	facilitates	facilitate	VBZ
cord-342936-43u7afl3	292	27	HCV	HCV	NNP
cord-342936-43u7afl3	292	28	transmission	transmission	NN
cord-342936-43u7afl3	292	29	to	to	IN
cord-342936-43u7afl3	292	30	proximal	proximal	JJ
cord-342936-43u7afl3	292	31	hepatocytes	hepatocyte	NNS
cord-342936-43u7afl3	292	32	102	102	CD
cord-342936-43u7afl3	292	33	.	.	.
cord-342936-43u7afl3	293	1	DC	DC	NNP
cord-342936-43u7afl3	293	2	-	-	HYPH
cord-342936-43u7afl3	293	3	SIGN	SIGN	NNP
cord-342936-43u7afl3	293	4	and	and	CC
cord-342936-43u7afl3	293	5	L	l	NN
cord-342936-43u7afl3	293	6	-	-	HYPH
cord-342936-43u7afl3	293	7	SIGN	SIGN	NNP
cord-342936-43u7afl3	293	8	were	be	VBD
cord-342936-43u7afl3	293	9	also	also	RB
cord-342936-43u7afl3	293	10	shown	show	VBN
cord-342936-43u7afl3	293	11	to	to	TO
cord-342936-43u7afl3	293	12	enhance	enhance	VB
cord-342936-43u7afl3	293	13	infection	infection	NN
cord-342936-43u7afl3	293	14	mediated	mediate	VBN
cord-342936-43u7afl3	293	15	by	by	IN
cord-342936-43u7afl3	293	16	the	the	DT
cord-342936-43u7afl3	293	17	Marburg	Marburg	NNP
cord-342936-43u7afl3	293	18	virus	virus	NN
cord-342936-43u7afl3	293	19	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	293	20	GP	GP	NNP
cord-342936-43u7afl3	293	21	and	and	CC
cord-342936-43u7afl3	293	22	the	the	DT
cord-342936-43u7afl3	293	23	S	S	NNP
cord-342936-43u7afl3	293	24	protein	protein	NN
cord-342936-43u7afl3	293	25	of	of	IN
cord-342936-43u7afl3	293	26	severe	severe	JJ
cord-342936-43u7afl3	293	27	acute	acute	JJ
cord-342936-43u7afl3	293	28	respiratory	respiratory	JJ
cord-342936-43u7afl3	293	29	syndrome	syndrome	NN
cord-342936-43u7afl3	293	30	coronavirus	coronavirus	NN
cord-342936-43u7afl3	293	31	(	(	-LRB-
cord-342936-43u7afl3	293	32	SARS	SARS	NNP
cord-342936-43u7afl3	293	33	-	-	HYPH
cord-342936-43u7afl3	293	34	CoV	CoV	NNP
cord-342936-43u7afl3	293	35	)	)	-RRB-
cord-342936-43u7afl3	293	36	through	through	IN
cord-342936-43u7afl3	293	37	pH	ph	NN
cord-342936-43u7afl3	293	38	-	-	HYPH
cord-342936-43u7afl3	293	39	dependent	dependent	JJ
cord-342936-43u7afl3	293	40	endocytosis	endocytosis	NN
cord-342936-43u7afl3	293	41	,	,	,
cord-342936-43u7afl3	293	42	and	and	CC
cord-342936-43u7afl3	293	43	might	may	MD
cord-342936-43u7afl3	293	44	promote	promote	VB
cord-342936-43u7afl3	293	45	virus	virus	NN
cord-342936-43u7afl3	293	46	dissemination	dissemination	NN
cord-342936-43u7afl3	293	47	103	103	CD
cord-342936-43u7afl3	293	48	.	.	.
cord-342936-43u7afl3	294	1	Although	although	IN
cord-342936-43u7afl3	294	2	M.	M.	NNP
cord-342936-43u7afl3	294	3	tuberculosis	tuberculosis	NN
cord-342936-43u7afl3	294	4	primarily	primarily	RB
cord-342936-43u7afl3	294	5	infects	infect	VBZ
cord-342936-43u7afl3	294	6	macrophages	macrophage	NNS
cord-342936-43u7afl3	294	7	,	,	,
cord-342936-43u7afl3	294	8	it	-PRON-	PRP
cord-342936-43u7afl3	294	9	also	also	RB
cord-342936-43u7afl3	294	10	binds	bind	VBZ
cord-342936-43u7afl3	294	11	to	to	IN
cord-342936-43u7afl3	294	12	DCs	dc	NNS
cord-342936-43u7afl3	294	13	through	through	IN
cord-342936-43u7afl3	294	14	the	the	DT
cord-342936-43u7afl3	294	15	interaction	interaction	NN
cord-342936-43u7afl3	294	16	of	of	IN
cord-342936-43u7afl3	294	17	its	-PRON-	PRP$
cord-342936-43u7afl3	294	18	cell	cell	NN
cord-342936-43u7afl3	294	19	-	-	HYPH
cord-342936-43u7afl3	294	20	wall	wall	NN
cord-342936-43u7afl3	294	21	component	component	NN
cord-342936-43u7afl3	294	22	ManLAM	ManLAM	NNP
cord-342936-43u7afl3	294	23	(	(	-LRB-
cord-342936-43u7afl3	294	24	mannosylated	mannosylated	NNP
cord-342936-43u7afl3	294	25	lipoarabinomannan	lipoarabinomannan	NNP
cord-342936-43u7afl3	294	26	)	)	-RRB-
cord-342936-43u7afl3	294	27	with	with	IN
cord-342936-43u7afl3	294	28	DC	DC	NNP
cord-342936-43u7afl3	294	29	-	-	HYPH
cord-342936-43u7afl3	294	30	SIGN	SIGN	NNP
cord-342936-43u7afl3	294	31	104	104	CD
cord-342936-43u7afl3	294	32	,	,	,
cord-342936-43u7afl3	294	33	105	105	CD
cord-342936-43u7afl3	294	34	.	.	.
cord-342936-43u7afl3	295	1	The	the	DT
cord-342936-43u7afl3	295	2	binding	binding	NN
cord-342936-43u7afl3	295	3	of	of	IN
cord-342936-43u7afl3	295	4	ManLAM	ManLAM	NNS
cord-342936-43u7afl3	295	5	to	to	IN
cord-342936-43u7afl3	295	6	DC	DC	NNP
cord-342936-43u7afl3	295	7	-	-	HYPH
cord-342936-43u7afl3	295	8	SIGN	SIGN	NNP
cord-342936-43u7afl3	295	9	on	on	IN
cord-342936-43u7afl3	295	10	DCs	DCs	NNP
cord-342936-43u7afl3	295	11	blocks	block	VBZ
cord-342936-43u7afl3	295	12	DC	DC	NNP
cord-342936-43u7afl3	295	13	maturation	maturation	NN
cord-342936-43u7afl3	295	14	and	and	CC
cord-342936-43u7afl3	295	15	induces	induce	VBZ
cord-342936-43u7afl3	295	16	the	the	DT
cord-342936-43u7afl3	295	17	expression	expression	NN
cord-342936-43u7afl3	295	18	of	of	IN
cord-342936-43u7afl3	295	19	immunosuppressive	immunosuppressive	JJ
cord-342936-43u7afl3	295	20	interleukin-10	interleukin-10	NN
cord-342936-43u7afl3	295	21	(	(	-LRB-
cord-342936-43u7afl3	295	22	IL-10	IL-10	NNP
cord-342936-43u7afl3	295	23	)	)	-RRB-
cord-342936-43u7afl3	295	24	104	104	CD
cord-342936-43u7afl3	295	25	.	.	.
cord-342936-43u7afl3	296	1	As	as	IN
cord-342936-43u7afl3	296	2	a	a	DT
cord-342936-43u7afl3	296	3	result	result	NN
cord-342936-43u7afl3	296	4	,	,	,
cord-342936-43u7afl3	296	5	M.	M.	NNP
cord-342936-43u7afl3	296	6	tuberculosis	tuberculosis	NN
cord-342936-43u7afl3	296	7	enables	enable	VBZ
cord-342936-43u7afl3	296	8	the	the	DT
cord-342936-43u7afl3	296	9	suppression	suppression	NN
cord-342936-43u7afl3	296	10	of	of	IN
cord-342936-43u7afl3	296	11	immune	immune	JJ
cord-342936-43u7afl3	296	12	activation	activation	NN
cord-342936-43u7afl3	296	13	signals	signal	NNS
cord-342936-43u7afl3	296	14	,	,	,
cord-342936-43u7afl3	296	15	which	which	WDT
cord-342936-43u7afl3	296	16	allows	allow	VBZ
cord-342936-43u7afl3	296	17	immune	immune	JJ
cord-342936-43u7afl3	296	18	escape	escape	NN
cord-342936-43u7afl3	296	19	.	.	.
cord-342936-43u7afl3	297	1	Probiotic	probiotic	JJ
cord-342936-43u7afl3	297	2	bacteria	bacteria	NNS
cord-342936-43u7afl3	297	3	,	,	,
cord-342936-43u7afl3	297	4	such	such	JJ
cord-342936-43u7afl3	297	5	as	as	IN
cord-342936-43u7afl3	297	6	Lactobacillus	lactobacillus	NN
cord-342936-43u7afl3	297	7	spp	spp	NNS
cord-342936-43u7afl3	297	8	.	.	.
cord-342936-43u7afl3	297	9	,	,	,
cord-342936-43u7afl3	297	10	also	also	RB
cord-342936-43u7afl3	297	11	exert	exert	VB
cord-342936-43u7afl3	297	12	immune	immune	JJ
cord-342936-43u7afl3	297	13	suppression	suppression	NN
cord-342936-43u7afl3	297	14	through	through	IN
cord-342936-43u7afl3	297	15	DC	DC	NNP
cord-342936-43u7afl3	297	16	-	-	HYPH
cord-342936-43u7afl3	297	17	SIGN	SIGN	NNP
cord-342936-43u7afl3	297	18	by	by	IN
cord-342936-43u7afl3	297	19	the	the	DT
cord-342936-43u7afl3	297	20	induction	induction	NN
cord-342936-43u7afl3	297	21	of	of	IN
cord-342936-43u7afl3	297	22	IL-10-producing	IL-10-producing	NNP
cord-342936-43u7afl3	297	23	regulatory	regulatory	JJ
cord-342936-43u7afl3	297	24	T	t	NN
cord-342936-43u7afl3	297	25	cells	cell	NNS
cord-342936-43u7afl3	297	26	106	106	CD
cord-342936-43u7afl3	297	27	.	.	.
cord-342936-43u7afl3	298	1	It	-PRON-	PRP
cord-342936-43u7afl3	298	2	has	have	VBZ
cord-342936-43u7afl3	298	3	recently	recently	RB
cord-342936-43u7afl3	298	4	been	be	VBN
cord-342936-43u7afl3	298	5	shown	show	VBN
cord-342936-43u7afl3	298	6	that	that	IN
cord-342936-43u7afl3	298	7	serotypes	serotype	NNS
cord-342936-43u7afl3	298	8	3	3	CD
cord-342936-43u7afl3	298	9	and	and	CC
cord-342936-43u7afl3	298	10	14	14	CD
cord-342936-43u7afl3	298	11	of	of	IN
cord-342936-43u7afl3	298	12	Streptococcus	Streptococcus	NNP
cord-342936-43u7afl3	298	13	pneumoniae	pneumoniae	NNS
cord-342936-43u7afl3	298	14	specifically	specifically	RB
cord-342936-43u7afl3	298	15	interact	interact	VBP
cord-342936-43u7afl3	298	16	with	with	IN
cord-342936-43u7afl3	298	17	DC	DC	NNP
cord-342936-43u7afl3	298	18	-	-	HYPH
cord-342936-43u7afl3	298	19	SIGN	SIGN	NNP
cord-342936-43u7afl3	298	20	through	through	IN
cord-342936-43u7afl3	298	21	the	the	DT
cord-342936-43u7afl3	298	22	capsular	capsular	JJ
cord-342936-43u7afl3	298	23	polysaccharide	polysaccharide	NN
cord-342936-43u7afl3	298	24	,	,	,
cord-342936-43u7afl3	298	25	but	but	CC
cord-342936-43u7afl3	298	26	the	the	DT
cord-342936-43u7afl3	298	27	immunological	immunological	JJ
cord-342936-43u7afl3	298	28	consequences	consequence	NNS
cord-342936-43u7afl3	298	29	are	be	VBP
cord-342936-43u7afl3	298	30	unclear	unclear	JJ
cord-342936-43u7afl3	298	31	107	107	CD
cord-342936-43u7afl3	298	32	.	.	.
cord-342936-43u7afl3	299	1	H.	H.	NNP
cord-342936-43u7afl3	299	2	pylori	pylori	NN
cord-342936-43u7afl3	299	3	and	and	CC
cord-342936-43u7afl3	299	4	the	the	DT
cord-342936-43u7afl3	299	5	parasite	parasite	NN
cord-342936-43u7afl3	299	6	(	(	-LRB-
cord-342936-43u7afl3	299	7	protozoa	protozoan	NNS
cord-342936-43u7afl3	299	8	)	)	-RRB-
cord-342936-43u7afl3	300	1	Schistosoma	Schistosoma	NNP
cord-342936-43u7afl3	300	2	mansoni	mansoni	NNP
cord-342936-43u7afl3	300	3	were	be	VBD
cord-342936-43u7afl3	300	4	shown	show	VBN
cord-342936-43u7afl3	300	5	to	to	TO
cord-342936-43u7afl3	300	6	bind	bind	VB
cord-342936-43u7afl3	300	7	to	to	IN
cord-342936-43u7afl3	300	8	DC	DC	NNP
cord-342936-43u7afl3	300	9	-	-	HYPH
cord-342936-43u7afl3	300	10	SIGN	sign	VB
cord-342936-43u7afl3	300	11	through	through	IN
cord-342936-43u7afl3	300	12	non	non	JJ
cord-342936-43u7afl3	300	13	-	-	JJ
cord-342936-43u7afl3	300	14	sialylated	sialylated	JJ
cord-342936-43u7afl3	300	15	Lewis	Lewis	NNP
cord-342936-43u7afl3	300	16	antigens	antigen	NNS
cord-342936-43u7afl3	300	17	that	that	WDT
cord-342936-43u7afl3	300	18	are	be	VBP
cord-342936-43u7afl3	300	19	expressed	express	VBN
cord-342936-43u7afl3	300	20	on	on	IN
cord-342936-43u7afl3	300	21	lipopolysaccharides	lipopolysaccharide	NNS
cord-342936-43u7afl3	300	22	of	of	IN
cord-342936-43u7afl3	300	23	the	the	DT
cord-342936-43u7afl3	300	24	bacterium	bacterium	NN
cord-342936-43u7afl3	300	25	and	and	CC
cord-342936-43u7afl3	300	26	the	the	DT
cord-342936-43u7afl3	300	27	cell	cell	NN
cord-342936-43u7afl3	300	28	-	-	HYPH
cord-342936-43u7afl3	300	29	wall	wall	NN
cord-342936-43u7afl3	300	30	glycolipids	glycolipid	NNS
cord-342936-43u7afl3	300	31	of	of	IN
cord-342936-43u7afl3	300	32	the	the	DT
cord-342936-43u7afl3	300	33	parasite	parasite	NN
cord-342936-43u7afl3	300	34	,	,	,
cord-342936-43u7afl3	300	35	respectively	respectively	RB
cord-342936-43u7afl3	300	36	108	108	CD
cord-342936-43u7afl3	300	37	,	,	,
cord-342936-43u7afl3	300	38	109	109	CD
cord-342936-43u7afl3	300	39	.	.	.
cord-342936-43u7afl3	301	1	This	this	DT
cord-342936-43u7afl3	301	2	results	result	VBZ
cord-342936-43u7afl3	301	3	in	in	IN
cord-342936-43u7afl3	301	4	immune	immune	JJ
cord-342936-43u7afl3	301	5	regulation	regulation	NN
cord-342936-43u7afl3	301	6	that	that	WDT
cord-342936-43u7afl3	301	7	is	be	VBZ
cord-342936-43u7afl3	301	8	to	to	IN
cord-342936-43u7afl3	301	9	the	the	DT
cord-342936-43u7afl3	301	10	advantage	advantage	NN
cord-342936-43u7afl3	301	11	of	of	IN
cord-342936-43u7afl3	301	12	the	the	DT
cord-342936-43u7afl3	301	13	pathogen	pathogen	NN
cord-342936-43u7afl3	301	14	110	110	CD
cord-342936-43u7afl3	301	15	,	,	,
cord-342936-43u7afl3	301	16	111	111	CD
cord-342936-43u7afl3	301	17	.	.	.
cord-342936-43u7afl3	302	1	Leishmania	Leishmania	NNP
cord-342936-43u7afl3	302	2	mexicana	mexicana	NN
cord-342936-43u7afl3	302	3	has	have	VBZ
cord-342936-43u7afl3	302	4	also	also	RB
cord-342936-43u7afl3	302	5	been	be	VBN
cord-342936-43u7afl3	302	6	shown	show	VBN
cord-342936-43u7afl3	302	7	to	to	TO
cord-342936-43u7afl3	302	8	express	express	VB
cord-342936-43u7afl3	302	9	glycoconjugates	glycoconjugate	NNS
cord-342936-43u7afl3	302	10	that	that	WDT
cord-342936-43u7afl3	302	11	are	be	VBP
cord-342936-43u7afl3	302	12	recognized	recognize	VBN
cord-342936-43u7afl3	302	13	by	by	IN
cord-342936-43u7afl3	302	14	DC	DC	NNP
cord-342936-43u7afl3	302	15	-	-	HYPH
cord-342936-43u7afl3	302	16	SIGN	SIGN	NNP
cord-342936-43u7afl3	302	17	108	108	CD
cord-342936-43u7afl3	302	18	.	.	.
cord-342936-43u7afl3	303	1	It	-PRON-	PRP
cord-342936-43u7afl3	303	2	is	be	VBZ
cord-342936-43u7afl3	303	3	clear	clear	JJ
cord-342936-43u7afl3	303	4	that	that	IN
cord-342936-43u7afl3	303	5	the	the	DT
cord-342936-43u7afl3	303	6	often	often	RB
cord-342936-43u7afl3	303	7	-	-	HYPH
cord-342936-43u7afl3	303	8	indispensable	indispensable	JJ
cord-342936-43u7afl3	303	9	interactions	interaction	NNS
cord-342936-43u7afl3	303	10	of	of	IN
cord-342936-43u7afl3	303	11	various	various	JJ
cord-342936-43u7afl3	303	12	pathogens	pathogen	NNS
cord-342936-43u7afl3	303	13	with	with	IN
cord-342936-43u7afl3	303	14	DC	DC	NNP
cord-342936-43u7afl3	303	15	-	-	HYPH
cord-342936-43u7afl3	303	16	SIGN	SIGN	NNP
cord-342936-43u7afl3	303	17	are	be	VBP
cord-342936-43u7afl3	303	18	required	require	VBN
cord-342936-43u7afl3	303	19	to	to	TO
cord-342936-43u7afl3	303	20	allow	allow	VB
cord-342936-43u7afl3	303	21	efficient	efficient	JJ
cord-342936-43u7afl3	303	22	pathogen	pathogen	NN
cord-342936-43u7afl3	303	23	transmission	transmission	NN
cord-342936-43u7afl3	303	24	to	to	IN
cord-342936-43u7afl3	303	25	its	-PRON-	PRP$
cord-342936-43u7afl3	303	26	eventual	eventual	JJ
cord-342936-43u7afl3	303	27	target	target	NN
cord-342936-43u7afl3	303	28	cells	cell	NNS
cord-342936-43u7afl3	303	29	and/or	and/or	CC
cord-342936-43u7afl3	303	30	immune	immune	JJ
cord-342936-43u7afl3	303	31	escape	escape	NN
cord-342936-43u7afl3	303	32	and	and	CC
cord-342936-43u7afl3	303	33	successful	successful	JJ
cord-342936-43u7afl3	303	34	persistence	persistence	NN
cord-342936-43u7afl3	303	35	in	in	IN
cord-342936-43u7afl3	303	36	the	the	DT
cord-342936-43u7afl3	303	37	host	host	NN
cord-342936-43u7afl3	303	38	.	.	.
cord-342936-43u7afl3	304	1	It	-PRON-	PRP
cord-342936-43u7afl3	304	2	is	be	VBZ
cord-342936-43u7afl3	304	3	therefore	therefore	RB
cord-342936-43u7afl3	304	4	likely	likely	JJ
cord-342936-43u7afl3	304	5	that	that	IN
cord-342936-43u7afl3	304	6	CBAs	cba	NNS
cord-342936-43u7afl3	304	7	,	,	,
cord-342936-43u7afl3	304	8	by	by	IN
cord-342936-43u7afl3	304	9	binding	bind	VBG
cord-342936-43u7afl3	304	10	to	to	IN
cord-342936-43u7afl3	304	11	the	the	DT
cord-342936-43u7afl3	304	12	pathogens	pathogen	NNS
cord-342936-43u7afl3	304	13	'	'	POS
cord-342936-43u7afl3	304	14	glycoconjugates	glycoconjugate	NNS
cord-342936-43u7afl3	304	15	,	,	,
cord-342936-43u7afl3	304	16	directly	directly	RB
cord-342936-43u7afl3	304	17	compete	compete	VB
cord-342936-43u7afl3	304	18	with	with	IN
cord-342936-43u7afl3	304	19	the	the	DT
cord-342936-43u7afl3	304	20	lectins	lectin	NNS
cord-342936-43u7afl3	304	21	of	of	IN
cord-342936-43u7afl3	304	22	the	the	DT
cord-342936-43u7afl3	304	23	innate	innate	JJ
cord-342936-43u7afl3	304	24	immune	immune	JJ
cord-342936-43u7afl3	304	25	system	system	NN
cord-342936-43u7afl3	304	26	.	.	.
cord-342936-43u7afl3	305	1	The	the	DT
cord-342936-43u7afl3	305	2	CBA	CBA	NNP
cord-342936-43u7afl3	305	3	may	may	MD
cord-342936-43u7afl3	305	4	prevent	prevent	VB
cord-342936-43u7afl3	305	5	efficient	efficient	JJ
cord-342936-43u7afl3	305	6	capture	capture	NN
cord-342936-43u7afl3	305	7	and	and	CC
cord-342936-43u7afl3	305	8	transmission	transmission	NN
cord-342936-43u7afl3	305	9	of	of	IN
cord-342936-43u7afl3	305	10	the	the	DT
cord-342936-43u7afl3	305	11	pathogen	pathogen	NN
cord-342936-43u7afl3	305	12	and/or	and/or	CC
cord-342936-43u7afl3	305	13	suppression	suppression	NN
cord-342936-43u7afl3	305	14	of	of	IN
cord-342936-43u7afl3	305	15	an	an	DT
cord-342936-43u7afl3	305	16	efficient	efficient	JJ
cord-342936-43u7afl3	305	17	immune	immune	JJ
cord-342936-43u7afl3	305	18	response	response	NN
cord-342936-43u7afl3	305	19	against	against	IN
cord-342936-43u7afl3	305	20	the	the	DT
cord-342936-43u7afl3	305	21	pathogen	pathogen	NN
cord-342936-43u7afl3	305	22	.	.	.
cord-342936-43u7afl3	306	1	Therefore	therefore	RB
cord-342936-43u7afl3	306	2	,	,	,
cord-342936-43u7afl3	306	3	it	-PRON-	PRP
cord-342936-43u7afl3	306	4	can	can	MD
cord-342936-43u7afl3	306	5	be	be	VB
cord-342936-43u7afl3	306	6	predicted	predict	VBN
cord-342936-43u7afl3	306	7	that	that	IN
cord-342936-43u7afl3	306	8	CBAs	cba	NNS
cord-342936-43u7afl3	306	9	may	may	MD
cord-342936-43u7afl3	306	10	have	have	VB
cord-342936-43u7afl3	306	11	a	a	DT
cord-342936-43u7afl3	306	12	more	more	RBR
cord-342936-43u7afl3	306	13	general	general	JJ
cord-342936-43u7afl3	306	14	role	role	NN
cord-342936-43u7afl3	306	15	in	in	IN
cord-342936-43u7afl3	306	16	abrogating	abrogate	VBG
cord-342936-43u7afl3	306	17	successful	successful	JJ
cord-342936-43u7afl3	306	18	pathogen	pathogen	NN
cord-342936-43u7afl3	306	19	infection	infection	NN
cord-342936-43u7afl3	306	20	and	and	CC
cord-342936-43u7afl3	306	21	persistence	persistence	NN
cord-342936-43u7afl3	306	22	.	.	.
cord-342936-43u7afl3	307	1	CBAs	CBAs	NNP
cord-342936-43u7afl3	307	2	should	should	MD
cord-342936-43u7afl3	307	3	,	,	,
cord-342936-43u7afl3	307	4	therefore	therefore	RB
cord-342936-43u7afl3	307	5	,	,	,
cord-342936-43u7afl3	307	6	be	be	VB
cord-342936-43u7afl3	307	7	put	put	VBN
cord-342936-43u7afl3	307	8	in	in	IN
cord-342936-43u7afl3	307	9	a	a	DT
cord-342936-43u7afl3	307	10	broader	broad	JJR
cord-342936-43u7afl3	307	11	microbial	microbial	JJ
cord-342936-43u7afl3	307	12	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	307	13	context	context	NN
cord-342936-43u7afl3	307	14	,	,	,
cord-342936-43u7afl3	307	15	and	and	CC
cord-342936-43u7afl3	307	16	not	not	RB
cord-342936-43u7afl3	307	17	be	be	VB
cord-342936-43u7afl3	307	18	explored	explore	VBN
cord-342936-43u7afl3	307	19	solely	solely	RB
cord-342936-43u7afl3	307	20	for	for	IN
cord-342936-43u7afl3	307	21	HIV	HIV	NNP
cord-342936-43u7afl3	307	22	therapy	therapy	NN
cord-342936-43u7afl3	307	23	.	.	.
cord-342936-43u7afl3	308	1	Unique	unique	JJ
cord-342936-43u7afl3	308	2	features	feature	NNS
cord-342936-43u7afl3	308	3	of	of	IN
cord-342936-43u7afl3	308	4	the	the	DT
cord-342936-43u7afl3	308	5	CBA	CBA	NNP
cord-342936-43u7afl3	308	6	concept	concept	NN
cord-342936-43u7afl3	308	7	It	-PRON-	PRP
cord-342936-43u7afl3	308	8	has	have	VBZ
cord-342936-43u7afl3	308	9	been	be	VBN
cord-342936-43u7afl3	308	10	unambiguously	unambiguously	RB
cord-342936-43u7afl3	308	11	shown	show	VBN
cord-342936-43u7afl3	308	12	that	that	IN
cord-342936-43u7afl3	308	13	CBAs	cba	NNS
cord-342936-43u7afl3	308	14	efficiently	efficiently	RB
cord-342936-43u7afl3	308	15	inhibit	inhibit	VBP
cord-342936-43u7afl3	308	16	virus	virus	NN
cord-342936-43u7afl3	308	17	entry	entry	NN
cord-342936-43u7afl3	308	18	by	by	IN
cord-342936-43u7afl3	308	19	inhibiting	inhibit	VBG
cord-342936-43u7afl3	308	20	the	the	DT
cord-342936-43u7afl3	308	21	fusion	fusion	NN
cord-342936-43u7afl3	308	22	of	of	IN
cord-342936-43u7afl3	308	23	cell	cell	NN
cord-342936-43u7afl3	308	24	-	-	HYPH
cord-342936-43u7afl3	308	25	free	free	JJ
cord-342936-43u7afl3	308	26	HIV	HIV	NNP
cord-342936-43u7afl3	308	27	particles	particle	NNS
cord-342936-43u7afl3	308	28	with	with	IN
cord-342936-43u7afl3	308	29	susceptible	susceptible	JJ
cord-342936-43u7afl3	308	30	cells	cell	NNS
cord-342936-43u7afl3	308	31	,	,	,
cord-342936-43u7afl3	308	32	and	and	CC
cord-342936-43u7afl3	308	33	forming	form	VBG
cord-342936-43u7afl3	308	34	syncytia	syncytia	NN
cord-342936-43u7afl3	308	35	between	between	IN
cord-342936-43u7afl3	308	36	persistently	persistently	RB
cord-342936-43u7afl3	308	37	infected	infect	VBN
cord-342936-43u7afl3	308	38	and	and	CC
cord-342936-43u7afl3	308	39	uninfected	uninfected	JJ
cord-342936-43u7afl3	308	40	cells	cell	NNS
cord-342936-43u7afl3	308	41	38	38	CD
cord-342936-43u7afl3	308	42	.	.	.
cord-342936-43u7afl3	309	1	CBAs	cba	NNS
cord-342936-43u7afl3	309	2	also	also	RB
cord-342936-43u7afl3	309	3	prevent	prevent	VBP
cord-342936-43u7afl3	309	4	the	the	DT
cord-342936-43u7afl3	309	5	capture	capture	NN
cord-342936-43u7afl3	309	6	of	of	IN
cord-342936-43u7afl3	309	7	virus	virus	NN
cord-342936-43u7afl3	309	8	particles	particle	NNS
cord-342936-43u7afl3	309	9	by	by	IN
cord-342936-43u7afl3	309	10	DC	DC	NNP
cord-342936-43u7afl3	309	11	-	-	HYPH
cord-342936-43u7afl3	309	12	SIGN	SIGN	NNP
cord-342936-43u7afl3	309	13	,	,	,
cord-342936-43u7afl3	309	14	and	and	CC
cord-342936-43u7afl3	309	15	the	the	DT
cord-342936-43u7afl3	309	16	subsequent	subsequent	JJ
cord-342936-43u7afl3	309	17	transmission	transmission	NN
cord-342936-43u7afl3	309	18	of	of	IN
cord-342936-43u7afl3	309	19	the	the	DT
cord-342936-43u7afl3	309	20	virus	virus	NN
cord-342936-43u7afl3	309	21	to	to	IN
cord-342936-43u7afl3	309	22	T	T	NNP
cord-342936-43u7afl3	309	23	cells	cell	NNS
cord-342936-43u7afl3	309	24	73	73	CD
cord-342936-43u7afl3	309	25	.	.	.
cord-342936-43u7afl3	310	1	CBA	CBA	NNP
cord-342936-43u7afl3	310	2	treatment	treatment	NN
cord-342936-43u7afl3	310	3	of	of	IN
cord-342936-43u7afl3	310	4	virus	virus	NN
cord-342936-43u7afl3	310	5	-	-	HYPH
cord-342936-43u7afl3	310	6	infected	infect	VBN
cord-342936-43u7afl3	310	7	cells	cell	NNS
cord-342936-43u7afl3	310	8	provokes	provoke	VBZ
cord-342936-43u7afl3	310	9	drug	drug	NN
cord-342936-43u7afl3	310	10	pressure	pressure	NN
cord-342936-43u7afl3	310	11	on	on	IN
cord-342936-43u7afl3	310	12	the	the	DT
cord-342936-43u7afl3	310	13	virus	virus	NN
cord-342936-43u7afl3	310	14	,	,	,
cord-342936-43u7afl3	310	15	resulting	result	VBG
cord-342936-43u7afl3	310	16	in	in	IN
cord-342936-43u7afl3	310	17	predominant	predominant	JJ
cord-342936-43u7afl3	310	18	deletions	deletion	NNS
cord-342936-43u7afl3	310	19	of	of	IN
cord-342936-43u7afl3	310	20	N	n	NN
cord-342936-43u7afl3	310	21	-	-	HYPH
cord-342936-43u7afl3	310	22	glycans	glycan	NNS
cord-342936-43u7afl3	310	23	in	in	IN
cord-342936-43u7afl3	310	24	the	the	DT
cord-342936-43u7afl3	310	25	HIV	HIV	NNP
cord-342936-43u7afl3	310	26	gp120	gp120	NNP
cord-342936-43u7afl3	310	27	envelope	envelope	NN
cord-342936-43u7afl3	310	28	121	121	CD
cord-342936-43u7afl3	310	29	.	.	.
cord-342936-43u7afl3	311	1	Such	such	JJ
cord-342936-43u7afl3	311	2	glycan	glycan	NN
cord-342936-43u7afl3	311	3	deletions	deletion	NNS
cord-342936-43u7afl3	311	4	uncover	uncover	VBP
cord-342936-43u7afl3	311	5	previously	previously	RB
cord-342936-43u7afl3	311	6	hidden	hide	VBN
cord-342936-43u7afl3	311	7	immunogenic	immunogenic	JJ
cord-342936-43u7afl3	311	8	epitopes	epitope	NNS
cord-342936-43u7afl3	311	9	on	on	IN
cord-342936-43u7afl3	311	10	gp120	gp120	NNP
cord-342936-43u7afl3	311	11	,	,	,
cord-342936-43u7afl3	311	12	which	which	WDT
cord-342936-43u7afl3	311	13	may	may	MD
cord-342936-43u7afl3	311	14	give	give	VB
cord-342936-43u7afl3	311	15	the	the	DT
cord-342936-43u7afl3	311	16	immune	immune	JJ
cord-342936-43u7afl3	311	17	system	system	NN
cord-342936-43u7afl3	311	18	the	the	DT
cord-342936-43u7afl3	311	19	opportunity	opportunity	NN
cord-342936-43u7afl3	311	20	to	to	TO
cord-342936-43u7afl3	311	21	produce	produce	VB
cord-342936-43u7afl3	311	22	a	a	DT
cord-342936-43u7afl3	311	23	humoral	humoral	JJ
cord-342936-43u7afl3	311	24	and/or	and/or	CC
cord-342936-43u7afl3	311	25	cellular	cellular	JJ
cord-342936-43u7afl3	311	26	response	response	NN
cord-342936-43u7afl3	311	27	(	(	-LRB-
cord-342936-43u7afl3	311	28	FIG	fig	NN
cord-342936-43u7afl3	311	29	.	.	.
cord-342936-43u7afl3	311	30	1	1	CD
cord-342936-43u7afl3	311	31	)	)	-RRB-
cord-342936-43u7afl3	311	32	.	.	.
cord-342936-43u7afl3	312	1	What	what	WP
cord-342936-43u7afl3	312	2	are	be	VBP
cord-342936-43u7afl3	312	3	the	the	DT
cord-342936-43u7afl3	312	4	unique	unique	JJ
cord-342936-43u7afl3	312	5	features	feature	NNS
cord-342936-43u7afl3	312	6	of	of	IN
cord-342936-43u7afl3	312	7	the	the	DT
cord-342936-43u7afl3	312	8	CBA	CBA	NNP
cord-342936-43u7afl3	312	9	concept	concept	NN
cord-342936-43u7afl3	312	10	that	that	WDT
cord-342936-43u7afl3	312	11	differentiate	differentiate	VBP
cord-342936-43u7afl3	312	12	this	this	DT
cord-342936-43u7afl3	312	13	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	312	14	approach	approach	NN
cord-342936-43u7afl3	312	15	from	from	IN
cord-342936-43u7afl3	312	16	those	those	DT
cord-342936-43u7afl3	312	17	that	that	WDT
cord-342936-43u7afl3	312	18	are	be	VBP
cord-342936-43u7afl3	312	19	currently	currently	RB
cord-342936-43u7afl3	312	20	available	available	JJ
cord-342936-43u7afl3	312	21	(	(	-LRB-
cord-342936-43u7afl3	312	22	BOX	box	NN
cord-342936-43u7afl3	312	23	2	2	CD
cord-342936-43u7afl3	312	24	)	)	-RRB-
cord-342936-43u7afl3	312	25	?	?	.
cord-342936-43u7afl3	313	1	•	•	NNP
cord-342936-43u7afl3	314	1	The	the	DT
cord-342936-43u7afl3	314	2	direct	direct	JJ
cord-342936-43u7afl3	314	3	interaction	interaction	NN
cord-342936-43u7afl3	314	4	of	of	IN
cord-342936-43u7afl3	314	5	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	314	6	-	-	HYPH
cord-342936-43u7afl3	314	7	binding	bind	VBG
cord-342936-43u7afl3	314	8	agents	agent	NNS
cord-342936-43u7afl3	314	9	(	(	-LRB-
cord-342936-43u7afl3	314	10	CBAs	CBAs	NNP
cord-342936-43u7afl3	314	11	)	)	-RRB-
cord-342936-43u7afl3	314	12	with	with	IN
cord-342936-43u7afl3	314	13	the	the	DT
cord-342936-43u7afl3	314	14	glycans	glycan	NNS
cord-342936-43u7afl3	314	15	of	of	IN
cord-342936-43u7afl3	314	16	the	the	DT
cord-342936-43u7afl3	314	17	viral	viral	JJ
cord-342936-43u7afl3	314	18	envelope	envelope	NN
cord-342936-43u7afl3	314	19	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	314	20	.	.	.
cord-342936-43u7afl3	315	1	•	•	NNP
cord-342936-43u7afl3	316	1	CBA	CBA	NNP
cord-342936-43u7afl3	316	2	pressure	pressure	NN
cord-342936-43u7afl3	316	3	forces	force	NNS
cord-342936-43u7afl3	316	4	HIV	HIV	NNP
cord-342936-43u7afl3	316	5	to	to	TO
cord-342936-43u7afl3	316	6	delete	delete	VB
cord-342936-43u7afl3	316	7	N	n	CD
cord-342936-43u7afl3	316	8	-	-	HYPH
cord-342936-43u7afl3	316	9	glycans	glycan	NNS
cord-342936-43u7afl3	316	10	in	in	IN
cord-342936-43u7afl3	316	11	the	the	DT
cord-342936-43u7afl3	316	12	envelope	envelope	NN
cord-342936-43u7afl3	316	13	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	316	14	gp120	gp120	NNP
cord-342936-43u7afl3	316	15	.	.	.
cord-342936-43u7afl3	317	1	•	•	NNP
cord-342936-43u7afl3	318	1	Multiple	multiple	JJ
cord-342936-43u7afl3	318	2	CBAs	cba	NNS
cord-342936-43u7afl3	318	3	bind	bind	VBP
cord-342936-43u7afl3	318	4	to	to	IN
cord-342936-43u7afl3	318	5	one	one	CD
cord-342936-43u7afl3	318	6	envelope	envelope	NN
cord-342936-43u7afl3	318	7	gp120	gp120	IN
cord-342936-43u7afl3	318	8	target	target	NN
cord-342936-43u7afl3	318	9	molecule	molecule	NN
cord-342936-43u7afl3	318	10	.	.	.
cord-342936-43u7afl3	319	1	•	•	NNP
cord-342936-43u7afl3	320	1	A	a	DT
cord-342936-43u7afl3	320	2	high	high	JJ
cord-342936-43u7afl3	320	3	genetic	genetic	JJ
cord-342936-43u7afl3	320	4	barrier	barrier	NN
cord-342936-43u7afl3	320	5	.	.	.
cord-342936-43u7afl3	321	1	•	•	NNP
cord-342936-43u7afl3	322	1	No	no	DT
cord-342936-43u7afl3	322	2	cross	cross	NN
cord-342936-43u7afl3	322	3	-	-	NN
cord-342936-43u7afl3	322	4	resistance	resistance	NN
cord-342936-43u7afl3	322	5	of	of	IN
cord-342936-43u7afl3	322	6	CBA	CBA	NNP
cord-342936-43u7afl3	322	7	-	-	HYPH
cord-342936-43u7afl3	322	8	resistant	resistant	JJ
cord-342936-43u7afl3	322	9	mutant	mutant	JJ
cord-342936-43u7afl3	322	10	virus	virus	NN
cord-342936-43u7afl3	322	11	strains	strain	NNS
cord-342936-43u7afl3	322	12	to	to	IN
cord-342936-43u7afl3	322	13	other	other	JJ
cord-342936-43u7afl3	322	14	antivirals	antiviral	NNS
cord-342936-43u7afl3	322	15	.	.	.
cord-342936-43u7afl3	323	1	•	•	NNP
cord-342936-43u7afl3	324	1	Altered	altered	JJ
cord-342936-43u7afl3	324	2	interaction	interaction	NN
cord-342936-43u7afl3	324	3	of	of	IN
cord-342936-43u7afl3	324	4	mutant	mutant	JJ
cord-342936-43u7afl3	324	5	(	(	-LRB-
cord-342936-43u7afl3	324	6	glycan	glycan	NN
cord-342936-43u7afl3	324	7	-	-	HYPH
cord-342936-43u7afl3	324	8	deleted	delete	VBN
cord-342936-43u7afl3	324	9	)	)	-RRB-
cord-342936-43u7afl3	324	10	viruses	virus	NNS
cord-342936-43u7afl3	324	11	with	with	IN
cord-342936-43u7afl3	324	12	target	target	NN
cord-342936-43u7afl3	324	13	cells	cell	NNS
cord-342936-43u7afl3	324	14	.	.	.
cord-342936-43u7afl3	325	1	•	•	NNP
cord-342936-43u7afl3	326	1	The	the	DT
cord-342936-43u7afl3	326	2	CBA	CBA	NNP
cord-342936-43u7afl3	326	3	-	-	HYPH
cord-342936-43u7afl3	326	4	induced	induce	VBN
cord-342936-43u7afl3	326	5	glycan	glycan	NN
cord-342936-43u7afl3	326	6	deletions	deletion	NNS
cord-342936-43u7afl3	326	7	compromise	compromise	VBP
cord-342936-43u7afl3	326	8	the	the	DT
cord-342936-43u7afl3	326	9	protective	protective	JJ
cord-342936-43u7afl3	326	10	role	role	NN
cord-342936-43u7afl3	326	11	of	of	IN
cord-342936-43u7afl3	326	12	the	the	DT
cord-342936-43u7afl3	326	13	intact	intact	JJ
cord-342936-43u7afl3	326	14	glycan	glycan	NN
cord-342936-43u7afl3	326	15	shield	shield	NN
cord-342936-43u7afl3	326	16	on	on	IN
cord-342936-43u7afl3	326	17	HIV	HIV	NNP
cord-342936-43u7afl3	326	18	gp120	gp120	NNP
cord-342936-43u7afl3	326	19	.	.	.
cord-342936-43u7afl3	327	1	•	•	NNP
cord-342936-43u7afl3	328	1	The	the	DT
cord-342936-43u7afl3	328	2	eventual	eventual	JJ
cord-342936-43u7afl3	328	3	antiviral	antiviral	JJ
cord-342936-43u7afl3	328	4	CBA	CBA	NNP
cord-342936-43u7afl3	328	5	activity	activity	NN
cord-342936-43u7afl3	328	6	may	may	MD
cord-342936-43u7afl3	328	7	combine	combine	VB
cord-342936-43u7afl3	328	8	a	a	DT
cord-342936-43u7afl3	328	9	direct	direct	JJ
cord-342936-43u7afl3	328	10	drug	drug	NN
cord-342936-43u7afl3	328	11	-	-	HYPH
cord-342936-43u7afl3	328	12	mediated	mediate	VBN
cord-342936-43u7afl3	328	13	virus	virus	NN
cord-342936-43u7afl3	328	14	suppression	suppression	NN
cord-342936-43u7afl3	328	15	and	and	CC
cord-342936-43u7afl3	328	16	an	an	DT
cord-342936-43u7afl3	328	17	indirect	indirect	NN
cord-342936-43u7afl3	328	18	(	(	-LRB-
cord-342936-43u7afl3	328	19	delayed	delay	VBN
cord-342936-43u7afl3	328	20	)	)	-RRB-
cord-342936-43u7afl3	328	21	induction	induction	NN
cord-342936-43u7afl3	328	22	of	of	IN
cord-342936-43u7afl3	328	23	a	a	DT
cord-342936-43u7afl3	328	24	specific	specific	JJ
cord-342936-43u7afl3	328	25	antiviral	antiviral	JJ
cord-342936-43u7afl3	328	26	immune	immune	JJ
cord-342936-43u7afl3	328	27	response	response	NN
cord-342936-43u7afl3	328	28	against	against	IN
cord-342936-43u7afl3	328	29	the	the	DT
cord-342936-43u7afl3	328	30	mutant	mutant	JJ
cord-342936-43u7afl3	328	31	gp120	gp120	NNP
cord-342936-43u7afl3	328	32	envelope	envelope	NN
cord-342936-43u7afl3	328	33	.	.	.
cord-342936-43u7afl3	329	1	•	•	NNP
cord-342936-43u7afl3	330	1	The	the	DT
cord-342936-43u7afl3	330	2	CBA	CBA	NNP
cord-342936-43u7afl3	330	3	concept	concept	NN
cord-342936-43u7afl3	330	4	may	may	MD
cord-342936-43u7afl3	330	5	also	also	RB
cord-342936-43u7afl3	330	6	apply	apply	VB
cord-342936-43u7afl3	330	7	to	to	IN
cord-342936-43u7afl3	330	8	other	other	JJ
cord-342936-43u7afl3	330	9	chronic	chronic	NN
cord-342936-43u7afl3	330	10	enveloped	envelop	VBN
cord-342936-43u7afl3	330	11	virus	virus	NN
cord-342936-43u7afl3	330	12	infections	infection	NNS
cord-342936-43u7afl3	330	13	,	,	,
cord-342936-43u7afl3	330	14	such	such	JJ
cord-342936-43u7afl3	330	15	as	as	IN
cord-342936-43u7afl3	330	16	the	the	DT
cord-342936-43u7afl3	330	17	human	human	JJ
cord-342936-43u7afl3	330	18	hepatitis	hepatitis	NN
cord-342936-43u7afl3	330	19	C	C	NNP
cord-342936-43u7afl3	330	20	virus	virus	NN
cord-342936-43u7afl3	330	21	.	.	.
cord-342936-43u7afl3	331	1	•	•	NNP
cord-342936-43u7afl3	332	1	Other	other	JJ
cord-342936-43u7afl3	332	2	pathogens	pathogen	NNS
cord-342936-43u7afl3	332	3	such	such	JJ
cord-342936-43u7afl3	332	4	as	as	IN
cord-342936-43u7afl3	332	5	dendritic	dendritic	JJ
cord-342936-43u7afl3	332	6	-	-	HYPH
cord-342936-43u7afl3	332	7	cell	cell	NN
cord-342936-43u7afl3	332	8	-	-	HYPH
cord-342936-43u7afl3	332	9	specific	specific	JJ
cord-342936-43u7afl3	332	10	intercellular	intercellular	JJ
cord-342936-43u7afl3	332	11	adhesion	adhesion	NN
cord-342936-43u7afl3	332	12	molecule	molecule	NN
cord-342936-43u7afl3	332	13	3-grabbing	3-grabbing	CD
cord-342936-43u7afl3	332	14	non	non	JJ
cord-342936-43u7afl3	332	15	-	-	JJ
cord-342936-43u7afl3	332	16	integrin	integrin	JJ
cord-342936-43u7afl3	332	17	(	(	-LRB-
cord-342936-43u7afl3	332	18	DC	DC	NNP
cord-342936-43u7afl3	332	19	-	-	HYPH
cord-342936-43u7afl3	332	20	SIGN)-recognizing	sign)-recognize	VBG
cord-342936-43u7afl3	332	21	bacteria	bacteria	NNS
cord-342936-43u7afl3	332	22	,	,	,
cord-342936-43u7afl3	332	23	fungi	fungus	NNS
cord-342936-43u7afl3	332	24	or	or	CC
cord-342936-43u7afl3	332	25	parasites	parasite	NNS
cord-342936-43u7afl3	332	26	may	may	MD
cord-342936-43u7afl3	332	27	also	also	RB
cord-342936-43u7afl3	332	28	be	be	VB
cord-342936-43u7afl3	332	29	susceptible	susceptible	JJ
cord-342936-43u7afl3	332	30	to	to	IN
cord-342936-43u7afl3	332	31	the	the	DT
cord-342936-43u7afl3	332	32	CBA	CBA	NNP
cord-342936-43u7afl3	332	33	approach	approach	NN
cord-342936-43u7afl3	332	34	.	.	.
cord-342936-43u7afl3	333	1	In	in	IN
cord-342936-43u7afl3	333	2	contrast	contrast	NN
cord-342936-43u7afl3	333	3	to	to	IN
cord-342936-43u7afl3	333	4	the	the	DT
cord-342936-43u7afl3	333	5	existing	exist	VBG
cord-342936-43u7afl3	333	6	drugs	drug	NNS
cord-342936-43u7afl3	333	7	for	for	IN
cord-342936-43u7afl3	333	8	the	the	DT
cord-342936-43u7afl3	333	9	treatment	treatment	NN
cord-342936-43u7afl3	333	10	of	of	IN
cord-342936-43u7afl3	333	11	HIV	HIV	NNP
cord-342936-43u7afl3	333	12	,	,	,
cord-342936-43u7afl3	333	13	which	which	WDT
cord-342936-43u7afl3	333	14	interact	interact	VBP
cord-342936-43u7afl3	333	15	with	with	IN
cord-342936-43u7afl3	333	16	specific	specific	JJ
cord-342936-43u7afl3	333	17	amino	amino	NN
cord-342936-43u7afl3	333	18	-	-	HYPH
cord-342936-43u7afl3	333	19	acid	acid	NN
cord-342936-43u7afl3	333	20	configurations	configuration	NNS
cord-342936-43u7afl3	333	21	on	on	IN
cord-342936-43u7afl3	333	22	their	-PRON-	PRP$
cord-342936-43u7afl3	333	23	target	target	NN
cord-342936-43u7afl3	333	24	proteins	protein	NNS
cord-342936-43u7afl3	333	25	,	,	,
cord-342936-43u7afl3	333	26	CBAs	cba	NNS
cord-342936-43u7afl3	333	27	directly	directly	RB
cord-342936-43u7afl3	333	28	interact	interact	VBP
cord-342936-43u7afl3	333	29	with	with	IN
cord-342936-43u7afl3	333	30	the	the	DT
cord-342936-43u7afl3	333	31	glycans	glycan	NNS
cord-342936-43u7afl3	333	32	that	that	WDT
cord-342936-43u7afl3	333	33	are	be	VBP
cord-342936-43u7afl3	333	34	present	present	JJ
cord-342936-43u7afl3	333	35	on	on	IN
cord-342936-43u7afl3	333	36	the	the	DT
cord-342936-43u7afl3	333	37	envelope	envelope	NN
cord-342936-43u7afl3	333	38	gp120	gp120	CD
cord-342936-43u7afl3	333	39	of	of	IN
cord-342936-43u7afl3	333	40	HIV	HIV	NNP
cord-342936-43u7afl3	333	41	.	.	.
cord-342936-43u7afl3	334	1	It	-PRON-	PRP
cord-342936-43u7afl3	334	2	is	be	VBZ
cord-342936-43u7afl3	334	3	important	important	JJ
cord-342936-43u7afl3	334	4	to	to	TO
cord-342936-43u7afl3	334	5	realize	realize	VB
cord-342936-43u7afl3	334	6	that	that	IN
cord-342936-43u7afl3	334	7	CBAs	cba	NNS
cord-342936-43u7afl3	334	8	do	do	VBP
cord-342936-43u7afl3	334	9	not	not	RB
cord-342936-43u7afl3	334	10	need	need	VB
cord-342936-43u7afl3	334	11	to	to	TO
cord-342936-43u7afl3	334	12	be	be	VB
cord-342936-43u7afl3	334	13	taken	take	VBN
cord-342936-43u7afl3	334	14	up	up	RP
cord-342936-43u7afl3	334	15	by	by	IN
cord-342936-43u7afl3	334	16	the	the	DT
cord-342936-43u7afl3	334	17	virus	virus	NN
cord-342936-43u7afl3	334	18	-	-	HYPH
cord-342936-43u7afl3	334	19	infected	infect	VBN
cord-342936-43u7afl3	334	20	cell	cell	NN
cord-342936-43u7afl3	334	21	in	in	IN
cord-342936-43u7afl3	334	22	order	order	NN
cord-342936-43u7afl3	334	23	to	to	TO
cord-342936-43u7afl3	334	24	exert	exert	VB
cord-342936-43u7afl3	334	25	their	-PRON-	PRP$
cord-342936-43u7afl3	334	26	antiviral	antiviral	JJ
cord-342936-43u7afl3	334	27	activity	activity	NN
cord-342936-43u7afl3	334	28	and	and	CC
cord-342936-43u7afl3	334	29	do	do	VBP
cord-342936-43u7afl3	334	30	not	not	RB
cord-342936-43u7afl3	334	31	interfere	interfere	VB
cord-342936-43u7afl3	334	32	with	with	IN
cord-342936-43u7afl3	334	33	the	the	DT
cord-342936-43u7afl3	334	34	synthesis	synthesis	NN
cord-342936-43u7afl3	334	35	of	of	IN
cord-342936-43u7afl3	334	36	the	the	DT
cord-342936-43u7afl3	334	37	glycans	glycan	NNS
cord-342936-43u7afl3	334	38	on	on	IN
cord-342936-43u7afl3	334	39	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	334	40	per	per	IN
cord-342936-43u7afl3	334	41	se	se	FW
cord-342936-43u7afl3	334	42	.	.	.
cord-342936-43u7afl3	335	1	In	in	IN
cord-342936-43u7afl3	335	2	this	this	DT
cord-342936-43u7afl3	335	3	respect	respect	NN
cord-342936-43u7afl3	335	4	,	,	,
cord-342936-43u7afl3	335	5	this	this	DT
cord-342936-43u7afl3	335	6	concept	concept	NN
cord-342936-43u7afl3	335	7	differs	differ	VBZ
cord-342936-43u7afl3	335	8	entirely	entirely	RB
cord-342936-43u7afl3	335	9	from	from	IN
cord-342936-43u7afl3	335	10	inhibitors	inhibitor	NNS
cord-342936-43u7afl3	335	11	of	of	IN
cord-342936-43u7afl3	335	12	cellular	cellular	JJ
cord-342936-43u7afl3	335	13	glycosylation	glycosylation	NN
cord-342936-43u7afl3	335	14	,	,	,
cord-342936-43u7afl3	335	15	such	such	JJ
cord-342936-43u7afl3	335	16	as	as	IN
cord-342936-43u7afl3	335	17	DMJ	DMJ	NNP
cord-342936-43u7afl3	335	18	and	and	CC
cord-342936-43u7afl3	335	19	castanospermine	castanospermine	NN
cord-342936-43u7afl3	335	20	,	,	,
cord-342936-43u7afl3	335	21	which	which	WDT
cord-342936-43u7afl3	335	22	aim	aim	VBP
cord-342936-43u7afl3	335	23	to	to	TO
cord-342936-43u7afl3	335	24	disturb	disturb	VB
cord-342936-43u7afl3	335	25	the	the	DT
cord-342936-43u7afl3	335	26	glycan	glycan	NN
cord-342936-43u7afl3	335	27	formation	formation	NN
cord-342936-43u7afl3	335	28	in	in	IN
cord-342936-43u7afl3	335	29	viral	viral	JJ
cord-342936-43u7afl3	335	30	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	335	31	,	,	,
cord-342936-43u7afl3	335	32	but	but	CC
cord-342936-43u7afl3	335	33	at	at	IN
cord-342936-43u7afl3	335	34	the	the	DT
cord-342936-43u7afl3	335	35	same	same	JJ
cord-342936-43u7afl3	335	36	time	time	NN
cord-342936-43u7afl3	335	37	may	may	MD
cord-342936-43u7afl3	335	38	also	also	RB
cord-342936-43u7afl3	335	39	disturb	disturb	VB
cord-342936-43u7afl3	335	40	the	the	DT
cord-342936-43u7afl3	335	41	formation	formation	NN
cord-342936-43u7afl3	335	42	of	of	IN
cord-342936-43u7afl3	335	43	glycans	glycan	NNS
cord-342936-43u7afl3	335	44	on	on	IN
cord-342936-43u7afl3	335	45	cellular	cellular	JJ
cord-342936-43u7afl3	335	46	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	335	47	.	.	.
cord-342936-43u7afl3	336	1	CBA	CBA	NNP
cord-342936-43u7afl3	336	2	pressure	pressure	NN
cord-342936-43u7afl3	336	3	progressively	progressively	RB
cord-342936-43u7afl3	336	4	forces	force	VBZ
cord-342936-43u7afl3	336	5	the	the	DT
cord-342936-43u7afl3	336	6	virus	virus	NN
cord-342936-43u7afl3	336	7	to	to	TO
cord-342936-43u7afl3	336	8	delete	delete	VB
cord-342936-43u7afl3	336	9	N	n	CD
cord-342936-43u7afl3	336	10	-	-	HYPH
cord-342936-43u7afl3	336	11	glycans	glycan	NNS
cord-342936-43u7afl3	336	12	in	in	IN
cord-342936-43u7afl3	336	13	gp120	gp120	NNP
cord-342936-43u7afl3	336	14	.	.	.
cord-342936-43u7afl3	337	1	This	this	DT
cord-342936-43u7afl3	337	2	mutational	mutational	JJ
cord-342936-43u7afl3	337	3	pattern	pattern	NN
cord-342936-43u7afl3	337	4	is	be	VBZ
cord-342936-43u7afl3	337	5	unique	unique	JJ
cord-342936-43u7afl3	337	6	and	and	CC
cord-342936-43u7afl3	337	7	does	do	VBZ
cord-342936-43u7afl3	337	8	not	not	RB
cord-342936-43u7afl3	337	9	consistently	consistently	RB
cord-342936-43u7afl3	337	10	occur	occur	VB
cord-342936-43u7afl3	337	11	in	in	IN
cord-342936-43u7afl3	337	12	the	the	DT
cord-342936-43u7afl3	337	13	presence	presence	NN
cord-342936-43u7afl3	337	14	of	of	IN
cord-342936-43u7afl3	337	15	other	other	JJ
cord-342936-43u7afl3	337	16	anti	anti	JJ
cord-342936-43u7afl3	337	17	-	-	JJ
cord-342936-43u7afl3	337	18	HIV	hiv	JJ
cord-342936-43u7afl3	337	19	drugs	drug	NNS
cord-342936-43u7afl3	337	20	,	,	,
cord-342936-43u7afl3	337	21	nor	nor	CC
cord-342936-43u7afl3	337	22	in	in	IN
cord-342936-43u7afl3	337	23	any	any	DT
cord-342936-43u7afl3	337	24	other	other	JJ
cord-342936-43u7afl3	337	25	known	know	VBN
cord-342936-43u7afl3	337	26	antiviral	antiviral	JJ
cord-342936-43u7afl3	337	27	.	.	.
cord-342936-43u7afl3	338	1	A	a	DT
cord-342936-43u7afl3	338	2	relatively	relatively	RB
cord-342936-43u7afl3	338	3	high	high	JJ
cord-342936-43u7afl3	338	4	number	number	NN
cord-342936-43u7afl3	338	5	of	of	IN
cord-342936-43u7afl3	338	6	N	n	NN
cord-342936-43u7afl3	338	7	-	-	HYPH
cord-342936-43u7afl3	338	8	glycans	glycan	NNS
cord-342936-43u7afl3	338	9	are	be	VBP
cord-342936-43u7afl3	338	10	present	present	JJ
cord-342936-43u7afl3	338	11	on	on	IN
cord-342936-43u7afl3	338	12	each	each	DT
cord-342936-43u7afl3	338	13	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	338	14	gp120	gp120	NNP
cord-342936-43u7afl3	338	15	molecule	molecule	NN
cord-342936-43u7afl3	338	16	(	(	-LRB-
cord-342936-43u7afl3	338	17	approximately	approximately	RB
cord-342936-43u7afl3	338	18	20	20	CD
cord-342936-43u7afl3	338	19	to	to	TO
cord-342936-43u7afl3	338	20	30	30	CD
cord-342936-43u7afl3	338	21	glycans	glycan	NNS
cord-342936-43u7afl3	338	22	,	,	,
cord-342936-43u7afl3	338	23	depending	depend	VBG
cord-342936-43u7afl3	338	24	on	on	IN
cord-342936-43u7afl3	338	25	the	the	DT
cord-342936-43u7afl3	338	26	nature	nature	NN
cord-342936-43u7afl3	338	27	of	of	IN
cord-342936-43u7afl3	338	28	the	the	DT
cord-342936-43u7afl3	338	29	virus	virus	NN
cord-342936-43u7afl3	338	30	clade	clade	NN
cord-342936-43u7afl3	338	31	and	and	CC
cord-342936-43u7afl3	339	1	the	the	DT
cord-342936-43u7afl3	339	2	individual	individual	JJ
cord-342936-43u7afl3	339	3	virus	virus	NN
cord-342936-43u7afl3	339	4	strain	strain	NN
cord-342936-43u7afl3	339	5	)	)	-RRB-
cord-342936-43u7afl3	339	6	87	87	CD
cord-342936-43u7afl3	339	7	.	.	.
cord-342936-43u7afl3	340	1	It	-PRON-	PRP
cord-342936-43u7afl3	340	2	can	can	MD
cord-342936-43u7afl3	340	3	be	be	VB
cord-342936-43u7afl3	340	4	reasonably	reasonably	RB
cord-342936-43u7afl3	340	5	assumed	assume	VBN
cord-342936-43u7afl3	340	6	that	that	IN
cord-342936-43u7afl3	340	7	multiple	multiple	JJ
cord-342936-43u7afl3	340	8	individual	individual	JJ
cord-342936-43u7afl3	340	9	CBAs	cba	NNS
cord-342936-43u7afl3	340	10	simultaneously	simultaneously	RB
cord-342936-43u7afl3	340	11	bind	bind	VB
cord-342936-43u7afl3	340	12	to	to	IN
cord-342936-43u7afl3	340	13	every	every	DT
cord-342936-43u7afl3	340	14	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	340	15	gp120	gp120	NNP
cord-342936-43u7afl3	340	16	molecule	molecule	NN
cord-342936-43u7afl3	340	17	.	.	.
cord-342936-43u7afl3	341	1	By	by	IN
cord-342936-43u7afl3	341	2	contrast	contrast	NN
cord-342936-43u7afl3	341	3	,	,	,
cord-342936-43u7afl3	341	4	HIVHIV-1	HIVHIV-1	NNP
cord-342936-43u7afl3	341	5	inhibitors	inhibitor	NNS
cord-342936-43u7afl3	341	6	other	other	JJ
cord-342936-43u7afl3	341	7	than	than	IN
cord-342936-43u7afl3	341	8	CBAs	cba	NNS
cord-342936-43u7afl3	341	9	stoichiometrically	stoichiometrically	RB
cord-342936-43u7afl3	341	10	bind	bind	VBP
cord-342936-43u7afl3	341	11	to	to	IN
cord-342936-43u7afl3	341	12	their	-PRON-	PRP$
cord-342936-43u7afl3	341	13	target	target	NN
cord-342936-43u7afl3	341	14	-one	-one	CD
cord-342936-43u7afl3	342	1	drug	drug	NN
cord-342936-43u7afl3	342	2	molecule	molecule	NN
cord-342936-43u7afl3	342	3	interacts	interact	VBZ
cord-342936-43u7afl3	342	4	with	with	IN
cord-342936-43u7afl3	342	5	one	one	CD
cord-342936-43u7afl3	342	6	target	target	NN
cord-342936-43u7afl3	342	7	protein	protein	NN
cord-342936-43u7afl3	342	8	molecule	molecule	NN
cord-342936-43u7afl3	342	9	.	.	.
cord-342936-43u7afl3	343	1	The	the	DT
cord-342936-43u7afl3	343	2	multiple	multiple	JJ
cord-342936-43u7afl3	343	3	bindings	binding	NNS
cord-342936-43u7afl3	343	4	of	of	IN
cord-342936-43u7afl3	343	5	CBAs	cba	NNS
cord-342936-43u7afl3	343	6	to	to	IN
cord-342936-43u7afl3	343	7	single	single	JJ
cord-342936-43u7afl3	343	8	gp120	gp120	NNP
cord-342936-43u7afl3	343	9	molecules	molecule	NNS
cord-342936-43u7afl3	343	10	results	result	NNS
cord-342936-43u7afl3	343	11	in	in	IN
cord-342936-43u7afl3	343	12	the	the	DT
cord-342936-43u7afl3	343	13	CBAs	cba	NNS
cord-342936-43u7afl3	343	14	having	have	VBG
cord-342936-43u7afl3	343	15	a	a	DT
cord-342936-43u7afl3	343	16	high	high	JJ
cord-342936-43u7afl3	343	17	genetic	genetic	JJ
cord-342936-43u7afl3	343	18	barrier	barrier	NN
cord-342936-43u7afl3	343	19	.	.	.
cord-342936-43u7afl3	344	1	This	this	DT
cord-342936-43u7afl3	344	2	means	mean	VBZ
cord-342936-43u7afl3	344	3	that	that	IN
cord-342936-43u7afl3	344	4	several	several	JJ
cord-342936-43u7afl3	344	5	mutations	mutation	NNS
cord-342936-43u7afl3	344	6	(	(	-LRB-
cord-342936-43u7afl3	344	7	owing	owe	VBG
cord-342936-43u7afl3	344	8	to	to	IN
cord-342936-43u7afl3	344	9	glycan	glycan	NN
cord-342936-43u7afl3	344	10	deletions	deletion	NNS
cord-342936-43u7afl3	344	11	)	)	-RRB-
cord-342936-43u7afl3	344	12	need	need	VBP
cord-342936-43u7afl3	344	13	to	to	TO
cord-342936-43u7afl3	344	14	accumulate	accumulate	VB
cord-342936-43u7afl3	344	15	in	in	IN
cord-342936-43u7afl3	344	16	gp120	gp120	NNP
cord-342936-43u7afl3	344	17	before	before	IN
cord-342936-43u7afl3	344	18	significant	significant	JJ
cord-342936-43u7afl3	344	19	phenotypic	phenotypic	JJ
cord-342936-43u7afl3	344	20	drug	drug	NN
cord-342936-43u7afl3	344	21	resistance	resistance	NN
cord-342936-43u7afl3	344	22	becomes	become	VBZ
cord-342936-43u7afl3	344	23	evident	evident	JJ
cord-342936-43u7afl3	344	24	.	.	.
cord-342936-43u7afl3	345	1	With	with	IN
cord-342936-43u7afl3	345	2	the	the	DT
cord-342936-43u7afl3	345	3	'	'	``
cord-342936-43u7afl3	345	4	traditional	traditional	JJ
cord-342936-43u7afl3	345	5	'	'	''
cord-342936-43u7afl3	345	6	current	current	JJ
cord-342936-43u7afl3	345	7	drugs	drug	NNS
cord-342936-43u7afl3	345	8	,	,	,
cord-342936-43u7afl3	345	9	the	the	DT
cord-342936-43u7afl3	345	10	appearance	appearance	NN
cord-342936-43u7afl3	345	11	of	of	IN
cord-342936-43u7afl3	345	12	a	a	DT
cord-342936-43u7afl3	345	13	single	single	JJ
cord-342936-43u7afl3	345	14	mutation	mutation	NN
cord-342936-43u7afl3	345	15	,	,	,
cord-342936-43u7afl3	345	16	or	or	CC
cord-342936-43u7afl3	345	17	at	at	RB
cord-342936-43u7afl3	345	18	least	least	JJS
cord-342936-43u7afl3	345	19	two	two	CD
cord-342936-43u7afl3	345	20	or	or	CC
cord-342936-43u7afl3	345	21	three	three	CD
cord-342936-43u7afl3	345	22	mutations	mutation	NNS
cord-342936-43u7afl3	345	23	in	in	IN
cord-342936-43u7afl3	345	24	the	the	DT
cord-342936-43u7afl3	345	25	target	target	NN
cord-342936-43u7afl3	345	26	protein	protein	NN
cord-342936-43u7afl3	345	27	,	,	,
cord-342936-43u7afl3	345	28	is	be	VBZ
cord-342936-43u7afl3	345	29	usually	usually	RB
cord-342936-43u7afl3	345	30	sufficient	sufficient	JJ
cord-342936-43u7afl3	345	31	to	to	TO
cord-342936-43u7afl3	345	32	produce	produce	VB
cord-342936-43u7afl3	345	33	a	a	DT
cord-342936-43u7afl3	345	34	significant	significant	JJ
cord-342936-43u7afl3	345	35	drop	drop	NN
cord-342936-43u7afl3	345	36	in	in	IN
cord-342936-43u7afl3	345	37	sensitivity	sensitivity	NN
cord-342936-43u7afl3	345	38	of	of	IN
cord-342936-43u7afl3	345	39	the	the	DT
cord-342936-43u7afl3	345	40	virus	virus	NN
cord-342936-43u7afl3	345	41	to	to	IN
cord-342936-43u7afl3	345	42	the	the	DT
cord-342936-43u7afl3	345	43	particular	particular	JJ
cord-342936-43u7afl3	345	44	drug	drug	NN
cord-342936-43u7afl3	345	45	.	.	.
cord-342936-43u7afl3	346	1	As	as	IN
cord-342936-43u7afl3	346	2	CBAs	cba	NNS
cord-342936-43u7afl3	346	3	selectively	selectively	RB
cord-342936-43u7afl3	346	4	target	target	VBP
cord-342936-43u7afl3	346	5	N	n	CD
cord-342936-43u7afl3	346	6	-	-	HYPH
cord-342936-43u7afl3	346	7	glycans	glycan	NNS
cord-342936-43u7afl3	346	8	on	on	IN
cord-342936-43u7afl3	346	9	gp120	gp120	NNP
cord-342936-43u7afl3	346	10	,	,	,
cord-342936-43u7afl3	346	11	CBA	CBA	NNP
cord-342936-43u7afl3	346	12	-	-	HYPH
cord-342936-43u7afl3	346	13	mutated	mutate	VBN
cord-342936-43u7afl3	346	14	virus	virus	NN
cord-342936-43u7afl3	346	15	strains	strain	NNS
cord-342936-43u7afl3	346	16	are	be	VBP
cord-342936-43u7afl3	346	17	not	not	RB
cord-342936-43u7afl3	346	18	likely	likely	JJ
cord-342936-43u7afl3	346	19	to	to	TO
cord-342936-43u7afl3	346	20	show	show	VB
cord-342936-43u7afl3	346	21	crossresistance	crossresistance	NN
cord-342936-43u7afl3	346	22	to	to	IN
cord-342936-43u7afl3	346	23	drugs	drug	NNS
cord-342936-43u7afl3	346	24	that	that	WDT
cord-342936-43u7afl3	346	25	act	act	VBP
cord-342936-43u7afl3	346	26	against	against	IN
cord-342936-43u7afl3	346	27	other	other	JJ
cord-342936-43u7afl3	346	28	targets	target	NNS
cord-342936-43u7afl3	346	29	(	(	-LRB-
cord-342936-43u7afl3	346	30	such	such	JJ
cord-342936-43u7afl3	346	31	as	as	IN
cord-342936-43u7afl3	346	32	protease	protease	NN
cord-342936-43u7afl3	346	33	,	,	,
cord-342936-43u7afl3	346	34	integrase	integrase	NN
cord-342936-43u7afl3	346	35	and	and	CC
cord-342936-43u7afl3	346	36	reverse	reverse	VB
cord-342936-43u7afl3	346	37	transcriptase	transcriptase	NN
cord-342936-43u7afl3	346	38	)	)	-RRB-
cord-342936-43u7afl3	346	39	.	.	.
cord-342936-43u7afl3	347	1	The	the	DT
cord-342936-43u7afl3	347	2	exception	exception	NN
cord-342936-43u7afl3	347	3	to	to	IN
cord-342936-43u7afl3	347	4	this	this	DT
cord-342936-43u7afl3	347	5	rule	rule	NN
cord-342936-43u7afl3	347	6	may	may	MD
cord-342936-43u7afl3	347	7	be	be	VB
cord-342936-43u7afl3	347	8	drugs	drug	NNS
cord-342936-43u7afl3	347	9	that	that	WDT
cord-342936-43u7afl3	347	10	target	target	VBP
cord-342936-43u7afl3	347	11	the	the	DT
cord-342936-43u7afl3	347	12	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	347	13	transmembrane	transmembrane	NN
cord-342936-43u7afl3	347	14	gp41	gp41	NNP
cord-342936-43u7afl3	347	15	.	.	.
cord-342936-43u7afl3	348	1	Indeed	indeed	RB
cord-342936-43u7afl3	348	2	,	,	,
cord-342936-43u7afl3	348	3	preliminary	preliminary	JJ
cord-342936-43u7afl3	348	4	findings	finding	NNS
cord-342936-43u7afl3	348	5	indicate	indicate	VBP
cord-342936-43u7afl3	348	6	that	that	IN
cord-342936-43u7afl3	348	7	some	some	DT
cord-342936-43u7afl3	348	8	mutant	mutant	JJ
cord-342936-43u7afl3	348	9	virus	virus	NN
cord-342936-43u7afl3	348	10	strains	strain	NNS
cord-342936-43u7afl3	348	11	that	that	WDT
cord-342936-43u7afl3	348	12	contain	contain	VBP
cord-342936-43u7afl3	348	13	various	various	JJ
cord-342936-43u7afl3	348	14	N	n	CD
cord-342936-43u7afl3	348	15	-	-	HYPH
cord-342936-43u7afl3	348	16	glycan	glycan	NN
cord-342936-43u7afl3	348	17	deletions	deletion	NNS
cord-342936-43u7afl3	348	18	in	in	IN
cord-342936-43u7afl3	348	19	gp120	gp120	DT
cord-342936-43u7afl3	348	20	show	show	VBP
cord-342936-43u7afl3	348	21	some	some	DT
cord-342936-43u7afl3	348	22	diminished	diminished	JJ
cord-342936-43u7afl3	348	23	sensitivity	sensitivity	NN
cord-342936-43u7afl3	348	24	to	to	IN
cord-342936-43u7afl3	348	25	the	the	DT
cord-342936-43u7afl3	348	26	fusion	fusion	NN
cord-342936-43u7afl3	348	27	gp41	gp41	NNP
cord-342936-43u7afl3	348	28	inhibitor	inhibitor	NN
cord-342936-43u7afl3	348	29	enfuvirtide	enfuvirtide	NNP
cord-342936-43u7afl3	348	30	(	(	-LRB-
cord-342936-43u7afl3	348	31	also	also	RB
cord-342936-43u7afl3	348	32	known	know	VBN
cord-342936-43u7afl3	348	33	as	as	IN
cord-342936-43u7afl3	348	34	T20	T20	NNP
cord-342936-43u7afl3	348	35	or	or	CC
cord-342936-43u7afl3	348	36	Fuzeon	Fuzeon	NNP
cord-342936-43u7afl3	348	37	)	)	-RRB-
cord-342936-43u7afl3	348	38	.	.	.
cord-342936-43u7afl3	349	1	It	-PRON-	PRP
cord-342936-43u7afl3	349	2	remains	remain	VBZ
cord-342936-43u7afl3	349	3	to	to	TO
cord-342936-43u7afl3	349	4	be	be	VB
cord-342936-43u7afl3	349	5	seen	see	VBN
cord-342936-43u7afl3	349	6	,	,	,
cord-342936-43u7afl3	349	7	however	however	RB
cord-342936-43u7afl3	349	8	,	,	,
cord-342936-43u7afl3	349	9	whether	whether	IN
cord-342936-43u7afl3	349	10	this	this	DT
cord-342936-43u7afl3	349	11	is	be	VBZ
cord-342936-43u7afl3	349	12	a	a	DT
cord-342936-43u7afl3	349	13	consistent	consistent	JJ
cord-342936-43u7afl3	349	14	behaviour	behaviour	NN
cord-342936-43u7afl3	349	15	of	of	IN
cord-342936-43u7afl3	349	16	these	these	DT
cord-342936-43u7afl3	349	17	mutant	mutant	JJ
cord-342936-43u7afl3	349	18	virus	virus	NN
cord-342936-43u7afl3	349	19	strains	strain	NNS
cord-342936-43u7afl3	349	20	or	or	CC
cord-342936-43u7afl3	349	21	whether	whether	IN
cord-342936-43u7afl3	349	22	the	the	DT
cord-342936-43u7afl3	349	23	particular	particular	JJ
cord-342936-43u7afl3	349	24	glycan	glycan	NN
cord-342936-43u7afl3	349	25	-	-	HYPH
cord-342936-43u7afl3	349	26	deleted	delete	VBN
cord-342936-43u7afl3	349	27	virus	virus	NN
cord-342936-43u7afl3	349	28	strains	strain	NNS
cord-342936-43u7afl3	349	29	have	have	VBP
cord-342936-43u7afl3	349	30	an	an	DT
cord-342936-43u7afl3	349	31	intrinsically	intrinsically	RB
cord-342936-43u7afl3	349	32	low	low	JJ
cord-342936-43u7afl3	349	33	sensitivity	sensitivity	NN
cord-342936-43u7afl3	349	34	to	to	TO
cord-342936-43u7afl3	349	35	enfuvirtide	enfuvirtide	NN
cord-342936-43u7afl3	349	36	that	that	WDT
cord-342936-43u7afl3	349	37	is	be	VBZ
cord-342936-43u7afl3	349	38	unrelated	unrelated	JJ
cord-342936-43u7afl3	349	39	to	to	IN
cord-342936-43u7afl3	349	40	the	the	DT
cord-342936-43u7afl3	349	41	absence	absence	NN
cord-342936-43u7afl3	349	42	of	of	IN
cord-342936-43u7afl3	349	43	some	some	DT
cord-342936-43u7afl3	349	44	of	of	IN
cord-342936-43u7afl3	349	45	the	the	DT
cord-342936-43u7afl3	349	46	N	n	NN
cord-342936-43u7afl3	349	47	-	-	HYPH
cord-342936-43u7afl3	349	48	glycans	glycan	NNS
cord-342936-43u7afl3	349	49	of	of	IN
cord-342936-43u7afl3	349	50	gp120	gp120	CD
cord-342936-43u7afl3	349	51	.	.	.
cord-342936-43u7afl3	350	1	Certain	certain	JJ
cord-342936-43u7afl3	350	2	glycans	glycan	NNS
cord-342936-43u7afl3	350	3	may	may	MD
cord-342936-43u7afl3	350	4	have	have	VB
cord-342936-43u7afl3	350	5	an	an	DT
cord-342936-43u7afl3	350	6	instrumental	instrumental	JJ
cord-342936-43u7afl3	350	7	role	role	NN
cord-342936-43u7afl3	350	8	in	in	IN
cord-342936-43u7afl3	350	9	the	the	DT
cord-342936-43u7afl3	350	10	correct	correct	JJ
cord-342936-43u7afl3	350	11	folding	folding	NN
cord-342936-43u7afl3	350	12	of	of	IN
cord-342936-43u7afl3	350	13	the	the	DT
cord-342936-43u7afl3	350	14	protein	protein	NN
cord-342936-43u7afl3	350	15	immediately	immediately	RB
cord-342936-43u7afl3	350	16	after	after	IN
cord-342936-43u7afl3	350	17	the	the	DT
cord-342936-43u7afl3	350	18	native	native	JJ
cord-342936-43u7afl3	350	19	peptide	peptide	NN
cord-342936-43u7afl3	350	20	has	have	VBZ
cord-342936-43u7afl3	350	21	been	be	VBN
cord-342936-43u7afl3	350	22	formed	form	VBN
cord-342936-43u7afl3	350	23	on	on	IN
cord-342936-43u7afl3	350	24	the	the	DT
cord-342936-43u7afl3	350	25	ribosomes	ribosome	NNS
cord-342936-43u7afl3	350	26	of	of	IN
cord-342936-43u7afl3	350	27	the	the	DT
cord-342936-43u7afl3	350	28	ER	ER	NNP
cord-342936-43u7afl3	350	29	7	7	CD
cord-342936-43u7afl3	350	30	.	.	.
cord-342936-43u7afl3	351	1	Therefore	therefore	RB
cord-342936-43u7afl3	351	2	,	,	,
cord-342936-43u7afl3	351	3	it	-PRON-	PRP
cord-342936-43u7afl3	351	4	can	can	MD
cord-342936-43u7afl3	351	5	be	be	VB
cord-342936-43u7afl3	351	6	expected	expect	VBN
cord-342936-43u7afl3	351	7	that	that	DT
cord-342936-43u7afl3	351	8	correct	correct	JJ
cord-342936-43u7afl3	351	9	folding	folding	NN
cord-342936-43u7afl3	351	10	can	can	MD
cord-342936-43u7afl3	351	11	become	become	VB
cord-342936-43u7afl3	351	12	hampered	hamper	VBN
cord-342936-43u7afl3	351	13	if	if	IN
cord-342936-43u7afl3	351	14	glycans	glycan	NNS
cord-342936-43u7afl3	351	15	are	be	VBP
cord-342936-43u7afl3	351	16	lacking	lack	VBG
cord-342936-43u7afl3	351	17	on	on	IN
cord-342936-43u7afl3	351	18	the	the	DT
cord-342936-43u7afl3	351	19	viral	viral	JJ
cord-342936-43u7afl3	351	20	envelope	envelope	NN
cord-342936-43u7afl3	351	21	after	after	IN
cord-342936-43u7afl3	351	22	amino	amino	NN
cord-342936-43u7afl3	351	23	-	-	HYPH
cord-342936-43u7afl3	351	24	acid	acid	NN
cord-342936-43u7afl3	351	25	mutation	mutation	NN
cord-342936-43u7afl3	351	26	of	of	IN
cord-342936-43u7afl3	351	27	the	the	DT
cord-342936-43u7afl3	351	28	glycosylation	glycosylation	NN
cord-342936-43u7afl3	351	29	motif	motif	NN
cord-342936-43u7afl3	351	30	.	.	.
cord-342936-43u7afl3	352	1	Such	such	JJ
cord-342936-43u7afl3	352	2	compromised	compromised	JJ
cord-342936-43u7afl3	352	3	(	(	-LRB-
cord-342936-43u7afl3	352	4	or	or	CC
cord-342936-43u7afl3	352	5	altered	alter	VBN
cord-342936-43u7afl3	352	6	)	)	-RRB-
cord-342936-43u7afl3	353	1	gp120	gp120	NNP
cord-342936-43u7afl3	353	2	folding	folding	NN
cord-342936-43u7afl3	353	3	may	may	MD
cord-342936-43u7afl3	353	4	affect	affect	VB
cord-342936-43u7afl3	353	5	the	the	DT
cord-342936-43u7afl3	353	6	efficient	efficient	JJ
cord-342936-43u7afl3	353	7	interaction	interaction	NN
cord-342936-43u7afl3	353	8	of	of	IN
cord-342936-43u7afl3	353	9	the	the	DT
cord-342936-43u7afl3	353	10	mutated	mutate	VBN
cord-342936-43u7afl3	353	11	gp120	gp120	CD
cord-342936-43u7afl3	353	12	envelope	envelope	NN
cord-342936-43u7afl3	353	13	with	with	IN
cord-342936-43u7afl3	353	14	the	the	DT
cord-342936-43u7afl3	353	15	co	co	NN
cord-342936-43u7afl3	353	16	-	-	NN
cord-342936-43u7afl3	353	17	receptor	receptor	JJ
cord-342936-43u7afl3	353	18	molecules	molecule	NNS
cord-342936-43u7afl3	353	19	,	,	,
cord-342936-43u7afl3	353	20	virus	virus	NN
cord-342936-43u7afl3	353	21	fusion	fusion	NN
cord-342936-43u7afl3	353	22	efficacy	efficacy	NN
cord-342936-43u7afl3	353	23	and	and	CC
cord-342936-43u7afl3	353	24	the	the	DT
cord-342936-43u7afl3	353	25	eventual	eventual	JJ
cord-342936-43u7afl3	353	26	fitness	fitness	NN
cord-342936-43u7afl3	353	27	of	of	IN
cord-342936-43u7afl3	353	28	the	the	DT
cord-342936-43u7afl3	353	29	mutant	mutant	JJ
cord-342936-43u7afl3	353	30	virus	virus	NN
cord-342936-43u7afl3	353	31	strains	strain	NNS
cord-342936-43u7afl3	353	32	.	.	.
cord-342936-43u7afl3	354	1	As	as	IN
cord-342936-43u7afl3	354	2	the	the	DT
cord-342936-43u7afl3	354	3	transmission	transmission	NN
cord-342936-43u7afl3	354	4	of	of	IN
cord-342936-43u7afl3	354	5	HIV	HIV	NNP
cord-342936-43u7afl3	354	6	is	be	VBZ
cord-342936-43u7afl3	354	7	believed	believe	VBN
cord-342936-43u7afl3	354	8	to	to	TO
cord-342936-43u7afl3	354	9	be	be	VB
cord-342936-43u7afl3	354	10	mediated	mediate	VBN
cord-342936-43u7afl3	354	11	by	by	IN
cord-342936-43u7afl3	354	12	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	354	13	-	-	HYPH
cord-342936-43u7afl3	354	14	recognizing	recognize	VBG
cord-342936-43u7afl3	354	15	DC	DC	NNP
cord-342936-43u7afl3	354	16	-	-	HYPH
cord-342936-43u7afl3	354	17	SIGN	sign	NN
cord-342936-43u7afl3	354	18	-	-	HYPH
cord-342936-43u7afl3	354	19	expressing	express	VBG
cord-342936-43u7afl3	354	20	cells	cell	NNS
cord-342936-43u7afl3	354	21	(	(	-LRB-
cord-342936-43u7afl3	354	22	that	that	RB
cord-342936-43u7afl3	354	23	is	is	RB
cord-342936-43u7afl3	354	24	,	,	,
cord-342936-43u7afl3	354	25	immature	immature	JJ
cord-342936-43u7afl3	354	26	DCs	dc	NNS
cord-342936-43u7afl3	354	27	)	)	-RRB-
cord-342936-43u7afl3	354	28	that	that	WDT
cord-342936-43u7afl3	354	29	are	be	VBP
cord-342936-43u7afl3	354	30	present	present	JJ
cord-342936-43u7afl3	354	31	in	in	IN
cord-342936-43u7afl3	354	32	the	the	DT
cord-342936-43u7afl3	354	33	vaginal	vaginal	JJ
cord-342936-43u7afl3	354	34	-	-	HYPH
cord-342936-43u7afl3	354	35	uterine	uterine	JJ
cord-342936-43u7afl3	354	36	mucosa	mucosa	JJ
cord-342936-43u7afl3	354	37	-	-	HYPH
cord-342936-43u7afl3	354	38	epithelial	epithelial	JJ
cord-342936-43u7afl3	354	39	border	border	NN
cord-342936-43u7afl3	354	40	46	46	CD
cord-342936-43u7afl3	354	41	,	,	,
cord-342936-43u7afl3	354	42	it	-PRON-	PRP
cord-342936-43u7afl3	354	43	can	can	MD
cord-342936-43u7afl3	354	44	be	be	VB
cord-342936-43u7afl3	354	45	assumed	assume	VBN
cord-342936-43u7afl3	354	46	that	that	IN
cord-342936-43u7afl3	354	47	the	the	DT
cord-342936-43u7afl3	354	48	mode	mode	NN
cord-342936-43u7afl3	354	49	of	of	IN
cord-342936-43u7afl3	354	50	interaction	interaction	NN
cord-342936-43u7afl3	354	51	of	of	IN
cord-342936-43u7afl3	354	52	cells	cell	NNS
cord-342936-43u7afl3	354	53	with	with	IN
cord-342936-43u7afl3	354	54	mutated	mutate	VBN
cord-342936-43u7afl3	354	55	glycan	glycan	NN
cord-342936-43u7afl3	354	56	-	-	HYPH
cord-342936-43u7afl3	354	57	deficient	deficient	JJ
cord-342936-43u7afl3	354	58	HIV	HIV	NNP
cord-342936-43u7afl3	354	59	particles	particle	NNS
cord-342936-43u7afl3	354	60	is	be	VBZ
cord-342936-43u7afl3	354	61	altered	alter	VBN
cord-342936-43u7afl3	354	62	owing	owe	VBG
cord-342936-43u7afl3	354	63	to	to	IN
cord-342936-43u7afl3	354	64	a	a	DT
cord-342936-43u7afl3	354	65	changed	change	VBN
cord-342936-43u7afl3	354	66	glycan	glycan	NN
cord-342936-43u7afl3	354	67	landscape	landscape	NN
cord-342936-43u7afl3	354	68	on	on	IN
cord-342936-43u7afl3	354	69	the	the	DT
cord-342936-43u7afl3	354	70	gp120	gp120	CD
cord-342936-43u7afl3	354	71	envelope	envelope	NN
cord-342936-43u7afl3	354	72	.	.	.
cord-342936-43u7afl3	355	1	The	the	DT
cord-342936-43u7afl3	355	2	protective	protective	JJ
cord-342936-43u7afl3	355	3	role	role	NN
cord-342936-43u7afl3	355	4	of	of	IN
cord-342936-43u7afl3	355	5	the	the	DT
cord-342936-43u7afl3	355	6	glycan	glycan	NN
cord-342936-43u7afl3	355	7	shield	shield	NN
cord-342936-43u7afl3	355	8	in	in	IN
cord-342936-43u7afl3	355	9	hiding	hide	VBG
cord-342936-43u7afl3	355	10	immunogenic	immunogenic	JJ
cord-342936-43u7afl3	355	11	epitopes	epitope	NNS
cord-342936-43u7afl3	355	12	on	on	IN
cord-342936-43u7afl3	355	13	gp120	gp120	NNP
cord-342936-43u7afl3	355	14	from	from	IN
cord-342936-43u7afl3	355	15	the	the	DT
cord-342936-43u7afl3	355	16	immune	immune	JJ
cord-342936-43u7afl3	355	17	system	system	NN
cord-342936-43u7afl3	355	18	may	may	MD
cord-342936-43u7afl3	355	19	get	get	VB
cord-342936-43u7afl3	355	20	lost	lose	VBN
cord-342936-43u7afl3	355	21	,	,	,
cord-342936-43u7afl3	355	22	or	or	CC
cord-342936-43u7afl3	355	23	at	at	IN
cord-342936-43u7afl3	355	24	least	least	JJS
cord-342936-43u7afl3	355	25	compromised	compromise	VBN
cord-342936-43u7afl3	355	26	,	,	,
cord-342936-43u7afl3	355	27	on	on	IN
cord-342936-43u7afl3	355	28	deletion	deletion	NN
cord-342936-43u7afl3	355	29	of	of	IN
cord-342936-43u7afl3	355	30	the	the	DT
cord-342936-43u7afl3	355	31	particular	particular	JJ
cord-342936-43u7afl3	355	32	glycans	glycan	NNS
cord-342936-43u7afl3	355	33	112	112	CD
cord-342936-43u7afl3	355	34	.	.	.
cord-342936-43u7afl3	356	1	Such	such	JJ
cord-342936-43u7afl3	356	2	glycan	glycan	NN
cord-342936-43u7afl3	356	3	deletions	deletion	NNS
cord-342936-43u7afl3	356	4	may	may	MD
cord-342936-43u7afl3	356	5	trigger	trigger	VB
cord-342936-43u7afl3	356	6	the	the	DT
cord-342936-43u7afl3	356	7	production	production	NN
cord-342936-43u7afl3	356	8	of	of	IN
cord-342936-43u7afl3	356	9	neutralizing	neutralize	VBG
cord-342936-43u7afl3	356	10	antibodies	antibody	NNS
cord-342936-43u7afl3	356	11	that	that	WDT
cord-342936-43u7afl3	356	12	are	be	VBP
cord-342936-43u7afl3	356	13	specific	specific	JJ
cord-342936-43u7afl3	356	14	for	for	IN
cord-342936-43u7afl3	356	15	those	those	DT
cord-342936-43u7afl3	356	16	gp120	gp120	NNP
cord-342936-43u7afl3	356	17	peptide	peptide	NN
cord-342936-43u7afl3	356	18	epitopes	epitope	NNS
cord-342936-43u7afl3	356	19	that	that	WDT
cord-342936-43u7afl3	356	20	were	be	VBD
cord-342936-43u7afl3	356	21	previously	previously	RB
cord-342936-43u7afl3	356	22	shielded	shield	VBN
cord-342936-43u7afl3	356	23	by	by	IN
cord-342936-43u7afl3	356	24	the	the	DT
cord-342936-43u7afl3	356	25	glycans	glycan	NNS
cord-342936-43u7afl3	356	26	.	.	.
cord-342936-43u7afl3	357	1	Whether	whether	IN
cord-342936-43u7afl3	357	2	this	this	DT
cord-342936-43u7afl3	357	3	phenomenon	phenomenon	NN
cord-342936-43u7afl3	357	4	will	will	MD
cord-342936-43u7afl3	357	5	occur	occur	VB
cord-342936-43u7afl3	357	6	in	in	IN
cord-342936-43u7afl3	357	7	CBA	CBA	NNP
cord-342936-43u7afl3	357	8	-	-	HYPH
cord-342936-43u7afl3	357	9	treated	treat	VBN
cord-342936-43u7afl3	357	10	HIV-1-infected	hiv-1-infecte	VBN
cord-342936-43u7afl3	357	11	individuals	individual	NNS
cord-342936-43u7afl3	357	12	remains	remain	VBZ
cord-342936-43u7afl3	357	13	to	to	TO
cord-342936-43u7afl3	357	14	be	be	VB
cord-342936-43u7afl3	357	15	determined	determine	VBN
cord-342936-43u7afl3	357	16	,	,	,
cord-342936-43u7afl3	357	17	but	but	CC
cord-342936-43u7afl3	357	18	it	-PRON-	PRP
cord-342936-43u7afl3	357	19	seems	seem	VBZ
cord-342936-43u7afl3	357	20	likely	likely	JJ
cord-342936-43u7afl3	357	21	.	.	.
cord-342936-43u7afl3	358	1	It	-PRON-	PRP
cord-342936-43u7afl3	358	2	is	be	VBZ
cord-342936-43u7afl3	358	3	also	also	RB
cord-342936-43u7afl3	358	4	currently	currently	RB
cord-342936-43u7afl3	358	5	unknown	unknown	JJ
cord-342936-43u7afl3	358	6	how	how	WRB
cord-342936-43u7afl3	358	7	strong	strong	JJ
cord-342936-43u7afl3	358	8	and	and	CC
cord-342936-43u7afl3	358	9	efficient	efficient	JJ
cord-342936-43u7afl3	358	10	the	the	DT
cord-342936-43u7afl3	358	11	neutralizing	neutralize	VBG
cord-342936-43u7afl3	358	12	antibody	antibody	NN
cord-342936-43u7afl3	358	13	response	response	NN
cord-342936-43u7afl3	358	14	will	will	MD
cord-342936-43u7afl3	358	15	be	be	VB
cord-342936-43u7afl3	358	16	on	on	IN
cord-342936-43u7afl3	358	17	the	the	DT
cord-342936-43u7afl3	358	18	mutant	mutant	JJ
cord-342936-43u7afl3	358	19	virus	virus	NN
cord-342936-43u7afl3	358	20	strains	strain	NNS
cord-342936-43u7afl3	358	21	that	that	WDT
cord-342936-43u7afl3	358	22	emerge	emerge	VBP
cord-342936-43u7afl3	358	23	under	under	IN
cord-342936-43u7afl3	358	24	CBA	CBA	NNP
cord-342936-43u7afl3	358	25	pressure	pressure	NN
cord-342936-43u7afl3	358	26	and	and	CC
cord-342936-43u7afl3	358	27	whether	whether	IN
cord-342936-43u7afl3	358	28	the	the	DT
cord-342936-43u7afl3	358	29	virus	virus	NN
cord-342936-43u7afl3	358	30	can	can	MD
cord-342936-43u7afl3	358	31	use	use	VB
cord-342936-43u7afl3	358	32	other	other	JJ
cord-342936-43u7afl3	358	33	immunological	immunological	JJ
cord-342936-43u7afl3	358	34	subversions	subversion	NNS
cord-342936-43u7afl3	358	35	to	to	TO
cord-342936-43u7afl3	358	36	circumvent	circumvent	VB
cord-342936-43u7afl3	358	37	CBA	CBA	NNP
cord-342936-43u7afl3	358	38	drug	drug	NN
cord-342936-43u7afl3	358	39	pressure	pressure	NN
cord-342936-43u7afl3	358	40	.	.	.
cord-342936-43u7afl3	359	1	It	-PRON-	PRP
cord-342936-43u7afl3	359	2	would	would	MD
cord-342936-43u7afl3	359	3	also	also	RB
cord-342936-43u7afl3	359	4	be	be	VB
cord-342936-43u7afl3	359	5	interesting	interesting	JJ
cord-342936-43u7afl3	359	6	to	to	TO
cord-342936-43u7afl3	359	7	see	see	VB
cord-342936-43u7afl3	359	8	whether	whether	IN
cord-342936-43u7afl3	359	9	,	,	,
cord-342936-43u7afl3	359	10	and	and	CC
cord-342936-43u7afl3	359	11	to	to	IN
cord-342936-43u7afl3	359	12	what	what	WDT
cord-342936-43u7afl3	359	13	extent	extent	NN
cord-342936-43u7afl3	359	14	,	,	,
cord-342936-43u7afl3	359	15	a	a	DT
cord-342936-43u7afl3	359	16	cellular	cellular	JJ
cord-342936-43u7afl3	359	17	immune	immune	JJ
cord-342936-43u7afl3	359	18	response	response	NN
cord-342936-43u7afl3	359	19	would	would	MD
cord-342936-43u7afl3	359	20	be	be	VB
cord-342936-43u7afl3	359	21	triggered	trigger	VBN
cord-342936-43u7afl3	359	22	under	under	IN
cord-342936-43u7afl3	359	23	such	such	JJ
cord-342936-43u7afl3	359	24	conditions	condition	NNS
cord-342936-43u7afl3	359	25	,	,	,
cord-342936-43u7afl3	359	26	and	and	CC
cord-342936-43u7afl3	359	27	what	what	WP
cord-342936-43u7afl3	359	28	contribution	contribution	NN
cord-342936-43u7afl3	359	29	a	a	DT
cord-342936-43u7afl3	359	30	provoked	provoke	VBN
cord-342936-43u7afl3	359	31	cellular	cellular	JJ
cord-342936-43u7afl3	359	32	immune	immune	JJ
cord-342936-43u7afl3	359	33	response	response	NN
cord-342936-43u7afl3	359	34	might	may	MD
cord-342936-43u7afl3	359	35	make	make	VB
cord-342936-43u7afl3	359	36	in	in	IN
cord-342936-43u7afl3	359	37	the	the	DT
cord-342936-43u7afl3	359	38	eventual	eventual	JJ
cord-342936-43u7afl3	359	39	inhibition	inhibition	NN
cord-342936-43u7afl3	359	40	of	of	IN
cord-342936-43u7afl3	359	41	the	the	DT
cord-342936-43u7afl3	359	42	virus	virus	NN
cord-342936-43u7afl3	359	43	infection	infection	NN
cord-342936-43u7afl3	359	44	in	in	IN
cord-342936-43u7afl3	359	45	CBA	CBA	NNP
cord-342936-43u7afl3	359	46	-	-	HYPH
cord-342936-43u7afl3	359	47	treated	treat	VBN
cord-342936-43u7afl3	359	48	individuals	individual	NNS
cord-342936-43u7afl3	359	49	.	.	.
cord-342936-43u7afl3	360	1	None	none	NN
cord-342936-43u7afl3	360	2	of	of	IN
cord-342936-43u7afl3	360	3	the	the	DT
cord-342936-43u7afl3	360	4	existing	exist	VBG
cord-342936-43u7afl3	360	5	antiviral	antiviral	JJ
cord-342936-43u7afl3	360	6	chemotherapeutics	chemotherapeutic	NNS
cord-342936-43u7afl3	360	7	has	have	VBZ
cord-342936-43u7afl3	360	8	been	be	VBN
cord-342936-43u7afl3	360	9	shown	show	VBN
cord-342936-43u7afl3	360	10	to	to	TO
cord-342936-43u7afl3	360	11	have	have	VB
cord-342936-43u7afl3	360	12	the	the	DT
cord-342936-43u7afl3	360	13	potential	potential	NN
cord-342936-43u7afl3	360	14	to	to	TO
cord-342936-43u7afl3	360	15	act	act	VB
cord-342936-43u7afl3	360	16	in	in	IN
cord-342936-43u7afl3	360	17	concert	concert	NN
cord-342936-43u7afl3	360	18	with	with	IN
cord-342936-43u7afl3	360	19	the	the	DT
cord-342936-43u7afl3	360	20	immune	immune	JJ
cord-342936-43u7afl3	360	21	system	system	NN
cord-342936-43u7afl3	360	22	to	to	TO
cord-342936-43u7afl3	360	23	further	further	RB
cord-342936-43u7afl3	360	24	increase	increase	VB
cord-342936-43u7afl3	360	25	the	the	DT
cord-342936-43u7afl3	360	26	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	360	27	pressure	pressure	NN
cord-342936-43u7afl3	360	28	on	on	IN
cord-342936-43u7afl3	360	29	the	the	DT
cord-342936-43u7afl3	360	30	mutated	mutate	VBN
cord-342936-43u7afl3	360	31	virus	virus	NN
cord-342936-43u7afl3	360	32	.	.	.
cord-342936-43u7afl3	361	1	Therefore	therefore	RB
cord-342936-43u7afl3	361	2	,	,	,
cord-342936-43u7afl3	361	3	treatment	treatment	NN
cord-342936-43u7afl3	361	4	of	of	IN
cord-342936-43u7afl3	361	5	HIV	HIV	NNP
cord-342936-43u7afl3	361	6	with	with	IN
cord-342936-43u7afl3	361	7	CBAs	cba	NNS
cord-342936-43u7afl3	361	8	may	may	MD
cord-342936-43u7afl3	361	9	become	become	VB
cord-342936-43u7afl3	361	10	the	the	DT
cord-342936-43u7afl3	361	11	first	first	JJ
cord-342936-43u7afl3	361	12	strategy	strategy	NN
cord-342936-43u7afl3	361	13	to	to	TO
cord-342936-43u7afl3	361	14	combine	combine	VB
cord-342936-43u7afl3	361	15	drug	drug	NN
cord-342936-43u7afl3	361	16	-	-	HYPH
cord-342936-43u7afl3	361	17	mediated	mediate	VBN
cord-342936-43u7afl3	361	18	virus	virus	NN
cord-342936-43u7afl3	361	19	suppression	suppression	NN
cord-342936-43u7afl3	361	20	and	and	CC
cord-342936-43u7afl3	361	21	induction	induction	NN
cord-342936-43u7afl3	361	22	of	of	IN
cord-342936-43u7afl3	361	23	a	a	DT
cord-342936-43u7afl3	361	24	specific	specific	JJ
cord-342936-43u7afl3	361	25	antiviral	antiviral	JJ
cord-342936-43u7afl3	361	26	immunological	immunological	JJ
cord-342936-43u7afl3	361	27	response	response	NN
cord-342936-43u7afl3	361	28	5	5	CD
cord-342936-43u7afl3	361	29	.	.	.
cord-342936-43u7afl3	362	1	Such	such	PDT
cord-342936-43u7afl3	362	2	a	a	DT
cord-342936-43u7afl3	362	3	phenomenon	phenomenon	NN
cord-342936-43u7afl3	362	4	may	may	MD
cord-342936-43u7afl3	362	5	result	result	VB
cord-342936-43u7afl3	362	6	in	in	IN
cord-342936-43u7afl3	362	7	'	'	``
cord-342936-43u7afl3	362	8	self	self	NN
cord-342936-43u7afl3	362	9	-	-	HYPH
cord-342936-43u7afl3	362	10	vaccination	vaccination	NN
cord-342936-43u7afl3	362	11	'	'	''
cord-342936-43u7afl3	362	12	of	of	IN
cord-342936-43u7afl3	362	13	the	the	DT
cord-342936-43u7afl3	362	14	CBA	CBA	NNP
cord-342936-43u7afl3	362	15	-	-	HYPH
cord-342936-43u7afl3	362	16	exposed	expose	VBN
cord-342936-43u7afl3	362	17	HIV	HIV	NNP
cord-342936-43u7afl3	362	18	-	-	HYPH
cord-342936-43u7afl3	362	19	infected	infect	VBN
cord-342936-43u7afl3	362	20	individuals	individual	NNS
cord-342936-43u7afl3	362	21	by	by	IN
cord-342936-43u7afl3	362	22	means	mean	NNS
cord-342936-43u7afl3	362	23	of	of	IN
cord-342936-43u7afl3	362	24	a	a	DT
cord-342936-43u7afl3	362	25	chemotherapeutic	chemotherapeutic	JJ
cord-342936-43u7afl3	362	26	agent	agent	NN
cord-342936-43u7afl3	362	27	.	.	.
cord-342936-43u7afl3	363	1	If	if	IN
cord-342936-43u7afl3	363	2	this	this	DT
cord-342936-43u7afl3	363	3	principle	principle	NN
cord-342936-43u7afl3	363	4	of	of	IN
cord-342936-43u7afl3	363	5	a	a	DT
cord-342936-43u7afl3	363	6	combined	combine	VBN
cord-342936-43u7afl3	363	7	concerted	concerted	JJ
cord-342936-43u7afl3	363	8	action	action	NN
cord-342936-43u7afl3	363	9	between	between	IN
cord-342936-43u7afl3	363	10	chemotherapy	chemotherapy	NN
cord-342936-43u7afl3	363	11	and	and	CC
cord-342936-43u7afl3	363	12	the	the	DT
cord-342936-43u7afl3	363	13	immune	immune	JJ
cord-342936-43u7afl3	363	14	response	response	NN
cord-342936-43u7afl3	363	15	proves	prove	VBZ
cord-342936-43u7afl3	363	16	valid	valid	JJ
cord-342936-43u7afl3	363	17	,	,	,
cord-342936-43u7afl3	363	18	it	-PRON-	PRP
cord-342936-43u7afl3	363	19	may	may	MD
cord-342936-43u7afl3	363	20	also	also	RB
cord-342936-43u7afl3	363	21	be	be	VB
cord-342936-43u7afl3	363	22	applied	apply	VBN
cord-342936-43u7afl3	363	23	to	to	IN
cord-342936-43u7afl3	363	24	other	other	JJ
cord-342936-43u7afl3	363	25	chronic	chronic	JJ
cord-342936-43u7afl3	363	26	infections	infection	NNS
cord-342936-43u7afl3	363	27	by	by	IN
cord-342936-43u7afl3	363	28	viruses	virus	NNS
cord-342936-43u7afl3	363	29	with	with	IN
cord-342936-43u7afl3	363	30	a	a	DT
cord-342936-43u7afl3	363	31	highly	highly	RB
cord-342936-43u7afl3	363	32	glycosylated	glycosylated	JJ
cord-342936-43u7afl3	363	33	envelope	envelope	NN
cord-342936-43u7afl3	363	34	,	,	,
cord-342936-43u7afl3	363	35	such	such	JJ
cord-342936-43u7afl3	363	36	as	as	IN
cord-342936-43u7afl3	363	37	HCV	HCV	NNP
cord-342936-43u7afl3	363	38	113	113	CD
cord-342936-43u7afl3	363	39	,	,	,
cord-342936-43u7afl3	363	40	114	114	CD
cord-342936-43u7afl3	363	41	.	.	.
cord-342936-43u7afl3	364	1	Also	also	RB
cord-342936-43u7afl3	364	2	,	,	,
cord-342936-43u7afl3	364	3	more	more	RBR
cord-342936-43u7afl3	364	4	acute	acute	JJ
cord-342936-43u7afl3	364	5	virus	virus	NN
cord-342936-43u7afl3	364	6	infections	infection	NNS
cord-342936-43u7afl3	364	7	(	(	-LRB-
cord-342936-43u7afl3	364	8	for	for	IN
cord-342936-43u7afl3	364	9	example	example	NN
cord-342936-43u7afl3	364	10	,	,	,
cord-342936-43u7afl3	364	11	influenza	influenza	NN
cord-342936-43u7afl3	364	12	virus	virus	NN
cord-342936-43u7afl3	364	13	,	,	,
cord-342936-43u7afl3	364	14	SARS	SARS	NNP
cord-342936-43u7afl3	364	15	-	-	HYPH
cord-342936-43u7afl3	364	16	CoV	CoV	NNP
cord-342936-43u7afl3	364	17	and	and	CC
cord-342936-43u7afl3	364	18	Ebola	Ebola	NNP
cord-342936-43u7afl3	364	19	virus	virus	NN
cord-342936-43u7afl3	364	20	)	)	-RRB-
cord-342936-43u7afl3	364	21	may	may	MD
cord-342936-43u7afl3	364	22	be	be	VB
cord-342936-43u7afl3	364	23	highly	highly	RB
cord-342936-43u7afl3	364	24	sensitive	sensitive	JJ
cord-342936-43u7afl3	364	25	to	to	IN
cord-342936-43u7afl3	364	26	the	the	DT
cord-342936-43u7afl3	364	27	inhibitory	inhibitory	JJ
cord-342936-43u7afl3	364	28	action	action	NN
cord-342936-43u7afl3	364	29	of	of	IN
cord-342936-43u7afl3	364	30	CBAs	cba	NNS
cord-342936-43u7afl3	364	31	,	,	,
cord-342936-43u7afl3	364	32	as	as	IN
cord-342936-43u7afl3	364	33	has	have	VBZ
cord-342936-43u7afl3	364	34	been	be	VBN
cord-342936-43u7afl3	364	35	shown	show	VBN
cord-342936-43u7afl3	364	36	for	for	IN
cord-342936-43u7afl3	364	37	certain	certain	JJ
cord-342936-43u7afl3	364	38	CBAs	cba	NNS
cord-342936-43u7afl3	364	39	against	against	IN
cord-342936-43u7afl3	364	40	feline	feline	JJ
cord-342936-43u7afl3	364	41	and	and	CC
cord-342936-43u7afl3	364	42	human	human	JJ
cord-342936-43u7afl3	364	43	coronaviruses	coronaviruse	NNS
cord-342936-43u7afl3	364	44	115	115	CD
cord-342936-43u7afl3	364	45	,	,	,
cord-342936-43u7afl3	364	46	116	116	CD
cord-342936-43u7afl3	364	47	and	and	CC
cord-342936-43u7afl3	364	48	for	for	IN
cord-342936-43u7afl3	364	49	CV	CV	NNP
cord-342936-43u7afl3	364	50	-	-	HYPH
cord-342936-43u7afl3	364	51	N	N	NNP
cord-342936-43u7afl3	364	52	against	against	IN
cord-342936-43u7afl3	364	53	Ebola	Ebola	NNP
cord-342936-43u7afl3	364	54	virus	virus	NN
cord-342936-43u7afl3	364	55	117	117	CD
cord-342936-43u7afl3	364	56	in	in	IN
cord-342936-43u7afl3	364	57	cell	cell	NN
cord-342936-43u7afl3	364	58	culture	culture	NN
cord-342936-43u7afl3	364	59	.	.	.
cord-342936-43u7afl3	365	1	Besides	besides	IN
cord-342936-43u7afl3	365	2	viruses	virus	NNS
cord-342936-43u7afl3	365	3	,	,	,
cord-342936-43u7afl3	365	4	other	other	JJ
cord-342936-43u7afl3	365	5	pathogens	pathogen	NNS
cord-342936-43u7afl3	365	6	,	,	,
cord-342936-43u7afl3	365	7	such	such	JJ
cord-342936-43u7afl3	365	8	as	as	IN
cord-342936-43u7afl3	365	9	the	the	DT
cord-342936-43u7afl3	365	10	DC	DC	NNP
cord-342936-43u7afl3	365	11	-	-	HYPH
cord-342936-43u7afl3	365	12	SIGN	sign	NN
cord-342936-43u7afl3	365	13	-	-	HYPH
cord-342936-43u7afl3	365	14	recognizing	recognize	VBG
cord-342936-43u7afl3	365	15	M.	M.	NNP
cord-342936-43u7afl3	365	16	tuberculosis	tuberculosis	NN
cord-342936-43u7afl3	365	17	and	and	CC
cord-342936-43u7afl3	365	18	H.	h.	NN
cord-342936-43u7afl3	365	19	pylori	pylori	NN
cord-342936-43u7afl3	365	20	or	or	CC
cord-342936-43u7afl3	365	21	fungi	fungus	NNS
cord-342936-43u7afl3	365	22	that	that	WDT
cord-342936-43u7afl3	365	23	contain	contain	VBP
cord-342936-43u7afl3	365	24	a	a	DT
cord-342936-43u7afl3	365	25	glycan	glycan	NN
cord-342936-43u7afl3	365	26	-	-	HYPH
cord-342936-43u7afl3	365	27	rich	rich	JJ
cord-342936-43u7afl3	365	28	cell	cell	NN
cord-342936-43u7afl3	365	29	wall	wall	NN
cord-342936-43u7afl3	365	30	(	(	-LRB-
cord-342936-43u7afl3	365	31	such	such	JJ
cord-342936-43u7afl3	365	32	as	as	IN
cord-342936-43u7afl3	365	33	Aspergillus	aspergillus	NN
cord-342936-43u7afl3	365	34	spp	spp	NNS
cord-342936-43u7afl3	365	35	.	.	.
cord-342936-43u7afl3	365	36	,	,	,
cord-342936-43u7afl3	365	37	Cryptococcus	Cryptococcus	NNP
cord-342936-43u7afl3	365	38	spp	spp	NNS
cord-342936-43u7afl3	365	39	.	.	.
cord-342936-43u7afl3	366	1	and	and	CC
cord-342936-43u7afl3	366	2	Candida	Candida	NNP
cord-342936-43u7afl3	366	3	spp	spp	NNS
cord-342936-43u7afl3	366	4	.	.	.
cord-342936-43u7afl3	366	5	)	)	-RRB-
cord-342936-43u7afl3	366	6	,	,	,
cord-342936-43u7afl3	366	7	and	and	CC
cord-342936-43u7afl3	366	8	even	even	RB
cord-342936-43u7afl3	366	9	parasites	parasite	NNS
cord-342936-43u7afl3	366	10	,	,	,
cord-342936-43u7afl3	366	11	may	may	MD
cord-342936-43u7afl3	366	12	become	become	VB
cord-342936-43u7afl3	366	13	ideal	ideal	JJ
cord-342936-43u7afl3	366	14	candidate	candidate	NN
cord-342936-43u7afl3	366	15	microorganisms	microorganism	NNS
cord-342936-43u7afl3	366	16	to	to	TO
cord-342936-43u7afl3	366	17	explore	explore	VB
cord-342936-43u7afl3	366	18	their	-PRON-	PRP$
cord-342936-43u7afl3	366	19	susceptibility	susceptibility	NN
cord-342936-43u7afl3	366	20	to	to	IN
cord-342936-43u7afl3	366	21	the	the	DT
cord-342936-43u7afl3	366	22	inhibitory	inhibitory	JJ
cord-342936-43u7afl3	366	23	action	action	NN
cord-342936-43u7afl3	366	24	of	of	IN
cord-342936-43u7afl3	366	25	CBAs	cba	NNS
cord-342936-43u7afl3	366	26	.	.	.
cord-342936-43u7afl3	367	1	Therefore	therefore	RB
cord-342936-43u7afl3	367	2	,	,	,
cord-342936-43u7afl3	367	3	the	the	DT
cord-342936-43u7afl3	367	4	potential	potential	NN
cord-342936-43u7afl3	367	5	of	of	IN
cord-342936-43u7afl3	367	6	CBAs	cba	NNS
cord-342936-43u7afl3	367	7	to	to	TO
cord-342936-43u7afl3	367	8	selectively	selectively	RB
cord-342936-43u7afl3	367	9	target	target	VB
cord-342936-43u7afl3	367	10	some	some	DT
cord-342936-43u7afl3	367	11	enveloped	envelop	VBN
cord-342936-43u7afl3	367	12	viruses	virus	NNS
cord-342936-43u7afl3	367	13	may	may	MD
cord-342936-43u7afl3	367	14	also	also	RB
cord-342936-43u7afl3	367	15	be	be	VB
cord-342936-43u7afl3	367	16	extended	extend	VBN
cord-342936-43u7afl3	367	17	to	to	IN
cord-342936-43u7afl3	367	18	other	other	JJ
cord-342936-43u7afl3	367	19	pathogens	pathogen	NNS
cord-342936-43u7afl3	367	20	of	of	IN
cord-342936-43u7afl3	367	21	an	an	DT
cord-342936-43u7afl3	367	22	entirely	entirely	RB
cord-342936-43u7afl3	367	23	different	different	JJ
cord-342936-43u7afl3	367	24	nature	nature	NN
cord-342936-43u7afl3	367	25	.	.	.
cord-342936-43u7afl3	368	1	If	if	IN
cord-342936-43u7afl3	368	2	the	the	DT
cord-342936-43u7afl3	368	3	glycans	glycan	NNS
cord-342936-43u7afl3	368	4	on	on	IN
cord-342936-43u7afl3	368	5	these	these	DT
cord-342936-43u7afl3	368	6	pathogens	pathogen	NNS
cord-342936-43u7afl3	368	7	are	be	VBP
cord-342936-43u7afl3	368	8	sufficiently	sufficiently	RB
cord-342936-43u7afl3	368	9	different	different	JJ
cord-342936-43u7afl3	368	10	from	from	IN
cord-342936-43u7afl3	368	11	those	those	DT
cord-342936-43u7afl3	368	12	of	of	IN
cord-342936-43u7afl3	368	13	the	the	DT
cord-342936-43u7afl3	368	14	host	host	NN
cord-342936-43u7afl3	368	15	,	,	,
cord-342936-43u7afl3	368	16	an	an	DT
cord-342936-43u7afl3	368	17	acceptable	acceptable	JJ
cord-342936-43u7afl3	368	18	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	368	19	window	window	NN
cord-342936-43u7afl3	368	20	may	may	MD
cord-342936-43u7afl3	368	21	be	be	VB
cord-342936-43u7afl3	368	22	achieved	achieve	VBN
cord-342936-43u7afl3	368	23	.	.	.
cord-342936-43u7afl3	369	1	Considering	consider	VBG
cord-342936-43u7afl3	369	2	CBAs	cba	NNS
cord-342936-43u7afl3	369	3	in	in	IN
cord-342936-43u7afl3	369	4	the	the	DT
cord-342936-43u7afl3	369	5	larger	large	JJR
cord-342936-43u7afl3	369	6	context	context	NN
cord-342936-43u7afl3	369	7	,	,	,
cord-342936-43u7afl3	369	8	beyond	beyond	IN
cord-342936-43u7afl3	369	9	that	that	DT
cord-342936-43u7afl3	369	10	of	of	IN
cord-342936-43u7afl3	369	11	the	the	DT
cord-342936-43u7afl3	369	12	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	369	13	field	field	NN
cord-342936-43u7afl3	369	14	of	of	IN
cord-342936-43u7afl3	369	15	virus	virus	NN
cord-342936-43u7afl3	369	16	infections	infection	NNS
cord-342936-43u7afl3	369	17	,	,	,
cord-342936-43u7afl3	369	18	may	may	MD
cord-342936-43u7afl3	369	19	reveal	reveal	VB
cord-342936-43u7afl3	369	20	an	an	DT
cord-342936-43u7afl3	369	21	unprecedented	unprecedented	JJ
cord-342936-43u7afl3	369	22	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	369	23	potential	potential	NN
cord-342936-43u7afl3	369	24	,	,	,
cord-342936-43u7afl3	369	25	and	and	CC
cord-342936-43u7afl3	369	26	should	should	MD
cord-342936-43u7afl3	369	27	trigger	trigger	VB
cord-342936-43u7afl3	369	28	extensive	extensive	JJ
cord-342936-43u7afl3	369	29	efforts	effort	NNS
cord-342936-43u7afl3	369	30	by	by	IN
cord-342936-43u7afl3	369	31	both	both	DT
cord-342936-43u7afl3	369	32	chemists	chemist	NNS
cord-342936-43u7afl3	369	33	and	and	CC
cord-342936-43u7afl3	369	34	microbiologists	microbiologist	NNS
cord-342936-43u7afl3	369	35	to	to	TO
cord-342936-43u7afl3	369	36	explore	explore	VB
cord-342936-43u7afl3	369	37	this	this	DT
cord-342936-43u7afl3	369	38	novel	novel	JJ
cord-342936-43u7afl3	369	39	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	369	40	avenue	avenue	NN
cord-342936-43u7afl3	369	41	in	in	IN
cord-342936-43u7afl3	369	42	the	the	DT
cord-342936-43u7afl3	369	43	broadest	broad	JJS
cord-342936-43u7afl3	369	44	possible	possible	JJ
cord-342936-43u7afl3	369	45	sense	sense	NN
cord-342936-43u7afl3	369	46	.	.	.
cord-342936-43u7afl3	370	1	Potential	potential	JJ
cord-342936-43u7afl3	370	2	pitfalls	pitfall	NNS
cord-342936-43u7afl3	370	3	of	of	IN
cord-342936-43u7afl3	370	4	the	the	DT
cord-342936-43u7afl3	370	5	CBA	CBA	NNP
cord-342936-43u7afl3	370	6	concept	concept	NN
cord-342936-43u7afl3	370	7	Virtually	virtually	RB
cord-342936-43u7afl3	370	8	all	all	DT
cord-342936-43u7afl3	370	9	known	know	VBN
cord-342936-43u7afl3	370	10	CBAs	cba	NNS
cord-342936-43u7afl3	370	11	that	that	WDT
cord-342936-43u7afl3	370	12	are	be	VBP
cord-342936-43u7afl3	370	13	inhibitory	inhibitory	JJ
cord-342936-43u7afl3	370	14	to	to	IN
cord-342936-43u7afl3	370	15	HIV	HIV	NNP
cord-342936-43u7afl3	370	16	infection	infection	NN
cord-342936-43u7afl3	370	17	(	(	-LRB-
cord-342936-43u7afl3	370	18	with	with	IN
cord-342936-43u7afl3	370	19	the	the	DT
cord-342936-43u7afl3	370	20	exception	exception	NN
cord-342936-43u7afl3	370	21	of	of	IN
cord-342936-43u7afl3	370	22	the	the	DT
cord-342936-43u7afl3	370	23	low	low	JJ
cord-342936-43u7afl3	370	24	-	-	HYPH
cord-342936-43u7afl3	370	25	molecular	molecular	JJ
cord-342936-43u7afl3	370	26	-	-	HYPH
cord-342936-43u7afl3	370	27	weight	weight	NN
cord-342936-43u7afl3	370	28	non	non	JJ
cord-342936-43u7afl3	370	29	-	-	JJ
cord-342936-43u7afl3	370	30	peptidic	peptidic	JJ
cord-342936-43u7afl3	370	31	antibiotic	antibiotic	JJ
cord-342936-43u7afl3	370	32	PRM	PRM	NNP
cord-342936-43u7afl3	370	33	-	-	HYPH
cord-342936-43u7afl3	370	34	A	A	NNP
cord-342936-43u7afl3	370	35	and	and	CC
cord-342936-43u7afl3	370	36	BMN	BMN	NNP
cord-342936-43u7afl3	370	37	-	-	HYPH
cord-342936-43u7afl3	370	38	A	A	NNP
cord-342936-43u7afl3	370	39	analogues	analogue	NNS
cord-342936-43u7afl3	370	40	(	(	-LRB-
cord-342936-43u7afl3	370	41	FIG	fig	NN
cord-342936-43u7afl3	370	42	.	.	.
cord-342936-43u7afl3	370	43	3	3	LS
cord-342936-43u7afl3	370	44	)	)	-RRB-
cord-342936-43u7afl3	370	45	)	)	-RRB-
cord-342936-43u7afl3	370	46	are	be	VBP
cord-342936-43u7afl3	370	47	proteins	protein	NNS
cord-342936-43u7afl3	370	48	.	.	.
cord-342936-43u7afl3	371	1	Such	such	JJ
cord-342936-43u7afl3	371	2	agents	agent	NNS
cord-342936-43u7afl3	371	3	are	be	VBP
cord-342936-43u7afl3	371	4	expensive	expensive	JJ
cord-342936-43u7afl3	371	5	to	to	TO
cord-342936-43u7afl3	371	6	produce	produce	VB
cord-342936-43u7afl3	371	7	,	,	,
cord-342936-43u7afl3	371	8	scale	scale	NN
cord-342936-43u7afl3	371	9	-	-	HYPH
cord-342936-43u7afl3	371	10	up	up	NN
cord-342936-43u7afl3	371	11	and	and	CC
cord-342936-43u7afl3	371	12	purify	purify	VB
cord-342936-43u7afl3	371	13	.	.	.
cord-342936-43u7afl3	372	1	There	there	EX
cord-342936-43u7afl3	372	2	may	may	MD
cord-342936-43u7afl3	372	3	also	also	RB
cord-342936-43u7afl3	372	4	be	be	VB
cord-342936-43u7afl3	372	5	storage	storage	NN
cord-342936-43u7afl3	372	6	and	and	CC
cord-342936-43u7afl3	372	7	stability	stability	NN
cord-342936-43u7afl3	372	8	problems	problem	NNS
cord-342936-43u7afl3	372	9	,	,	,
cord-342936-43u7afl3	372	10	although	although	IN
cord-342936-43u7afl3	372	11	some	some	DT
cord-342936-43u7afl3	372	12	plant	plant	NN
cord-342936-43u7afl3	372	13	lectins	lectin	NNS
cord-342936-43u7afl3	372	14	are	be	VBP
cord-342936-43u7afl3	372	15	remarkably	remarkably	RB
cord-342936-43u7afl3	372	16	temperature	temperature	NN
cord-342936-43u7afl3	372	17	-	-	:
cord-342936-43u7afl3	372	18	and	and	CC
cord-342936-43u7afl3	372	19	pH	ph	NN
cord-342936-43u7afl3	372	20	-	-	HYPH
cord-342936-43u7afl3	372	21	stable	stable	JJ
cord-342936-43u7afl3	372	22	34	34	CD
cord-342936-43u7afl3	372	23	,	,	,
cord-342936-43u7afl3	372	24	40	40	CD
cord-342936-43u7afl3	372	25	.	.	.
cord-342936-43u7afl3	373	1	Bioavailability	bioavailability	NN
cord-342936-43u7afl3	373	2	is	be	VBZ
cord-342936-43u7afl3	373	3	also	also	RB
cord-342936-43u7afl3	373	4	expected	expect	VBN
cord-342936-43u7afl3	373	5	to	to	TO
cord-342936-43u7afl3	373	6	be	be	VB
cord-342936-43u7afl3	373	7	low	low	JJ
cord-342936-43u7afl3	373	8	for	for	IN
cord-342936-43u7afl3	373	9	peptidic	peptidic	JJ
cord-342936-43u7afl3	373	10	CBAs	cba	NNS
cord-342936-43u7afl3	373	11	and	and	CC
cord-342936-43u7afl3	373	12	,	,	,
cord-342936-43u7afl3	373	13	therefore	therefore	RB
cord-342936-43u7afl3	373	14	,	,	,
cord-342936-43u7afl3	373	15	their	-PRON-	PRP$
cord-342936-43u7afl3	373	16	pharmacokinetics	pharmacokinetic	NNS
cord-342936-43u7afl3	373	17	and	and	CC
cord-342936-43u7afl3	373	18	pharmacodynamics	pharmacodynamic	NNS
cord-342936-43u7afl3	373	19	could	could	MD
cord-342936-43u7afl3	373	20	be	be	VB
cord-342936-43u7afl3	373	21	unfavourable	unfavourable	JJ
cord-342936-43u7afl3	373	22	,	,	,
cord-342936-43u7afl3	373	23	particularly	particularly	RB
cord-342936-43u7afl3	373	24	for	for	IN
cord-342936-43u7afl3	373	25	chronic	chronic	JJ
cord-342936-43u7afl3	373	26	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	373	27	administration	administration	NN
cord-342936-43u7afl3	373	28	.	.	.
cord-342936-43u7afl3	374	1	Besides	besides	IN
cord-342936-43u7afl3	374	2	a	a	DT
cord-342936-43u7afl3	374	3	sometimes	sometimes	RB
cord-342936-43u7afl3	374	4	pronounced	pronounce	VBN
cord-342936-43u7afl3	374	5	mitogenic	mitogenic	NNP
cord-342936-43u7afl3	374	6	and	and	CC
cord-342936-43u7afl3	374	7	red	red	JJ
cord-342936-43u7afl3	374	8	-	-	HYPH
cord-342936-43u7afl3	374	9	blood	blood	NN
cord-342936-43u7afl3	374	10	-	-	HYPH
cord-342936-43u7afl3	374	11	cell	cell	NN
cord-342936-43u7afl3	374	12	-	-	HYPH
cord-342936-43u7afl3	374	13	agglutinating	agglutinate	VBG
cord-342936-43u7afl3	374	14	activity	activity	NN
cord-342936-43u7afl3	374	15	,	,	,
cord-342936-43u7afl3	374	16	lectins	lectin	NNS
cord-342936-43u7afl3	374	17	might	may	MD
cord-342936-43u7afl3	374	18	also	also	RB
cord-342936-43u7afl3	374	19	be	be	VB
cord-342936-43u7afl3	374	20	endowed	endow	VBN
cord-342936-43u7afl3	374	21	with	with	IN
cord-342936-43u7afl3	374	22	inflammatory	inflammatory	JJ
cord-342936-43u7afl3	374	23	activity	activity	NN
cord-342936-43u7afl3	374	24	and	and	CC
cord-342936-43u7afl3	374	25	cellular	cellular	JJ
cord-342936-43u7afl3	374	26	toxicity	toxicity	NN
cord-342936-43u7afl3	374	27	34	34	CD
cord-342936-43u7afl3	374	28	.	.	.
cord-342936-43u7afl3	375	1	Also	also	RB
cord-342936-43u7afl3	375	2	,	,	,
cord-342936-43u7afl3	375	3	lectins	lectin	NNS
cord-342936-43u7afl3	375	4	such	such	JJ
cord-342936-43u7afl3	375	5	as	as	IN
cord-342936-43u7afl3	375	6	CV	CV	NNP
cord-342936-43u7afl3	375	7	-	-	HYPH
cord-342936-43u7afl3	375	8	N	N	NNP
cord-342936-43u7afl3	375	9	have	have	VBP
cord-342936-43u7afl3	375	10	the	the	DT
cord-342936-43u7afl3	375	11	capacity	capacity	NN
cord-342936-43u7afl3	375	12	to	to	TO
cord-342936-43u7afl3	375	13	stimulate	stimulate	VB
cord-342936-43u7afl3	375	14	various	various	JJ
cord-342936-43u7afl3	375	15	differentiation	differentiation	NN
cord-342936-43u7afl3	375	16	markers	marker	NNS
cord-342936-43u7afl3	375	17	(	(	-LRB-
cord-342936-43u7afl3	375	18	such	such	JJ
cord-342936-43u7afl3	375	19	as	as	IN
cord-342936-43u7afl3	375	20	CD25	CD25	NNP
cord-342936-43u7afl3	375	21	,	,	,
cord-342936-43u7afl3	375	22	CD69	CD69	NNP
cord-342936-43u7afl3	375	23	and	and	CC
cord-342936-43u7afl3	375	24	human	human	JJ
cord-342936-43u7afl3	375	25	leukocyte	leukocyte	NN
cord-342936-43u7afl3	375	26	antigen	antigen	NN
cord-342936-43u7afl3	375	27	(	(	-LRB-
cord-342936-43u7afl3	375	28	HLA	HLA	NNP
cord-342936-43u7afl3	375	29	-	-	HYPH
cord-342936-43u7afl3	375	30	DR	DR	NNP
cord-342936-43u7afl3	375	31	)	)	-RRB-
cord-342936-43u7afl3	375	32	)	)	-RRB-
cord-342936-43u7afl3	375	33	69	69	CD
cord-342936-43u7afl3	375	34	.	.	.
cord-342936-43u7afl3	376	1	Again	again	RB
cord-342936-43u7afl3	376	2	,	,	,
cord-342936-43u7afl3	376	3	it	-PRON-	PRP
cord-342936-43u7afl3	376	4	must	must	MD
cord-342936-43u7afl3	376	5	be	be	VB
cord-342936-43u7afl3	376	6	emphasized	emphasize	VBN
cord-342936-43u7afl3	376	7	that	that	IN
cord-342936-43u7afl3	376	8	,	,	,
cord-342936-43u7afl3	376	9	although	although	IN
cord-342936-43u7afl3	376	10	these	these	DT
cord-342936-43u7afl3	376	11	properties	property	NNS
cord-342936-43u7afl3	376	12	are	be	VBP
cord-342936-43u7afl3	376	13	unfavourable	unfavourable	JJ
cord-342936-43u7afl3	376	14	and	and	CC
cord-342936-43u7afl3	376	15	undesirable	undesirable	JJ
cord-342936-43u7afl3	376	16	from	from	IN
cord-342936-43u7afl3	376	17	a	a	DT
cord-342936-43u7afl3	376	18	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	376	19	viewpoint	viewpoint	NN
cord-342936-43u7afl3	376	20	,	,	,
cord-342936-43u7afl3	376	21	the	the	DT
cord-342936-43u7afl3	376	22	number	number	NN
cord-342936-43u7afl3	376	23	and	and	CC
cord-342936-43u7afl3	376	24	intensity	intensity	NN
cord-342936-43u7afl3	376	25	of	of	IN
cord-342936-43u7afl3	376	26	biological	biological	JJ
cord-342936-43u7afl3	376	27	side	side	NN
cord-342936-43u7afl3	376	28	effects	effect	NNS
cord-342936-43u7afl3	376	29	is	be	VBZ
cord-342936-43u7afl3	376	30	highly	highly	RB
cord-342936-43u7afl3	376	31	dependent	dependent	JJ
cord-342936-43u7afl3	376	32	on	on	IN
cord-342936-43u7afl3	376	33	the	the	DT
cord-342936-43u7afl3	376	34	nature	nature	NN
cord-342936-43u7afl3	376	35	of	of	IN
cord-342936-43u7afl3	376	36	the	the	DT
cord-342936-43u7afl3	376	37	CBA	CBA	NNP
cord-342936-43u7afl3	376	38	.	.	.
cord-342936-43u7afl3	377	1	For	for	IN
cord-342936-43u7afl3	377	2	example	example	NN
cord-342936-43u7afl3	377	3	,	,	,
cord-342936-43u7afl3	377	4	whereas	whereas	IN
cord-342936-43u7afl3	377	5	CV	CV	NNP
cord-342936-43u7afl3	377	6	-	-	HYPH
cord-342936-43u7afl3	377	7	N	N	NNP
cord-342936-43u7afl3	377	8	was	be	VBD
cord-342936-43u7afl3	377	9	shown	show	VBN
cord-342936-43u7afl3	377	10	to	to	TO
cord-342936-43u7afl3	377	11	display	display	VB
cord-342936-43u7afl3	377	12	a	a	DT
cord-342936-43u7afl3	377	13	broad	broad	JJ
cord-342936-43u7afl3	377	14	variety	variety	NN
cord-342936-43u7afl3	377	15	of	of	IN
cord-342936-43u7afl3	377	16	side	side	NN
cord-342936-43u7afl3	377	17	effects	effect	NNS
cord-342936-43u7afl3	377	18	69	69	CD
cord-342936-43u7afl3	377	19	,	,	,
cord-342936-43u7afl3	377	20	other	other	JJ
cord-342936-43u7afl3	377	21	CBAs	cba	NNS
cord-342936-43u7afl3	377	22	such	such	JJ
cord-342936-43u7afl3	377	23	as	as	IN
cord-342936-43u7afl3	377	24	GNA	GNA	NNP
cord-342936-43u7afl3	377	25	and	and	CC
cord-342936-43u7afl3	377	26	HHA	HHA	NNP
cord-342936-43u7afl3	377	27	showed	show	VBD
cord-342936-43u7afl3	377	28	much	much	RB
cord-342936-43u7afl3	377	29	fewer	few	JJR
cord-342936-43u7afl3	377	30	,	,	,
cord-342936-43u7afl3	377	31	if	if	IN
cord-342936-43u7afl3	377	32	any	any	DT
cord-342936-43u7afl3	377	33	,	,	,
cord-342936-43u7afl3	377	34	side	side	NN
cord-342936-43u7afl3	377	35	effects	effect	NNS
cord-342936-43u7afl3	377	36	118	118	CD
cord-342936-43u7afl3	377	37	.	.	.
cord-342936-43u7afl3	378	1	Moreover	moreover	RB
cord-342936-43u7afl3	378	2	,	,	,
cord-342936-43u7afl3	378	3	some	some	DT
cord-342936-43u7afl3	378	4	of	of	IN
cord-342936-43u7afl3	378	5	the	the	DT
cord-342936-43u7afl3	378	6	side	side	NN
cord-342936-43u7afl3	378	7	effects	effect	NNS
cord-342936-43u7afl3	378	8	that	that	WDT
cord-342936-43u7afl3	378	9	were	be	VBD
cord-342936-43u7afl3	378	10	observed	observe	VBN
cord-342936-43u7afl3	378	11	for	for	IN
cord-342936-43u7afl3	378	12	CV	CV	NNP
cord-342936-43u7afl3	378	13	-	-	HYPH
cord-342936-43u7afl3	378	14	N	N	NNP
cord-342936-43u7afl3	378	15	were	be	VBD
cord-342936-43u7afl3	378	16	shown	show	VBN
cord-342936-43u7afl3	378	17	to	to	TO
cord-342936-43u7afl3	378	18	be	be	VB
cord-342936-43u7afl3	378	19	independent	independent	JJ
cord-342936-43u7afl3	378	20	of	of	IN
cord-342936-43u7afl3	378	21	its	-PRON-	PRP$
cord-342936-43u7afl3	378	22	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	378	23	-	-	HYPH
cord-342936-43u7afl3	378	24	binding	bind	VBG
cord-342936-43u7afl3	378	25	properties	property	NNS
cord-342936-43u7afl3	378	26	69	69	CD
cord-342936-43u7afl3	378	27	.	.	.
cord-342936-43u7afl3	379	1	Therefore	therefore	RB
cord-342936-43u7afl3	379	2	,	,	,
cord-342936-43u7afl3	379	3	the	the	DT
cord-342936-43u7afl3	379	4	proper	proper	JJ
cord-342936-43u7afl3	379	5	selection	selection	NN
cord-342936-43u7afl3	379	6	of	of	IN
cord-342936-43u7afl3	379	7	CBAs	cba	NNS
cord-342936-43u7afl3	379	8	that	that	WDT
cord-342936-43u7afl3	379	9	have	have	VBP
cord-342936-43u7afl3	379	10	a	a	DT
cord-342936-43u7afl3	379	11	high	high	JJ
cord-342936-43u7afl3	379	12	selectivity	selectivity	NN
cord-342936-43u7afl3	379	13	for	for	IN
cord-342936-43u7afl3	379	14	viral	viral	JJ
cord-342936-43u7afl3	379	15	glycans	glycan	NNS
cord-342936-43u7afl3	379	16	and	and	CC
cord-342936-43u7afl3	379	17	minimal	minimal	JJ
cord-342936-43u7afl3	379	18	cellular	cellular	JJ
cord-342936-43u7afl3	379	19	side	side	NN
cord-342936-43u7afl3	379	20	effects	effect	NNS
cord-342936-43u7afl3	379	21	must	must	MD
cord-342936-43u7afl3	379	22	be	be	VB
cord-342936-43u7afl3	379	23	an	an	DT
cord-342936-43u7afl3	379	24	achievable	achievable	JJ
cord-342936-43u7afl3	379	25	goal	goal	NN
cord-342936-43u7afl3	379	26	.	.	.
cord-342936-43u7afl3	380	1	Given	give	VBN
cord-342936-43u7afl3	380	2	the	the	DT
cord-342936-43u7afl3	380	3	proteinaceous	proteinaceous	JJ
cord-342936-43u7afl3	380	4	nature	nature	NN
cord-342936-43u7afl3	380	5	of	of	IN
cord-342936-43u7afl3	380	6	lectins	lectin	NNS
cord-342936-43u7afl3	380	7	,	,	,
cord-342936-43u7afl3	380	8	it	-PRON-	PRP
cord-342936-43u7afl3	380	9	could	could	MD
cord-342936-43u7afl3	380	10	be	be	VB
cord-342936-43u7afl3	380	11	assumed	assume	VBN
cord-342936-43u7afl3	380	12	that	that	IN
cord-342936-43u7afl3	380	13	repeated	repeat	VBN
cord-342936-43u7afl3	380	14	systemic	systemic	JJ
cord-342936-43u7afl3	380	15	administration	administration	NN
cord-342936-43u7afl3	380	16	of	of	IN
cord-342936-43u7afl3	380	17	CBAs	CBAs	NNPS
cord-342936-43u7afl3	380	18	will	will	MD
cord-342936-43u7afl3	380	19	eventually	eventually	RB
cord-342936-43u7afl3	380	20	elicit	elicit	VB
cord-342936-43u7afl3	380	21	a	a	DT
cord-342936-43u7afl3	380	22	specific	specific	JJ
cord-342936-43u7afl3	380	23	antibody	antibody	NN
cord-342936-43u7afl3	380	24	response	response	NN
cord-342936-43u7afl3	380	25	.	.	.
cord-342936-43u7afl3	381	1	Such	such	PDT
cord-342936-43u7afl3	381	2	a	a	DT
cord-342936-43u7afl3	381	3	reaction	reaction	NN
cord-342936-43u7afl3	381	4	by	by	IN
cord-342936-43u7afl3	381	5	the	the	DT
cord-342936-43u7afl3	381	6	immune	immune	JJ
cord-342936-43u7afl3	381	7	system	system	NN
cord-342936-43u7afl3	381	8	may	may	MD
cord-342936-43u7afl3	381	9	hamper	hamper	VB
cord-342936-43u7afl3	381	10	and	and	CC
cord-342936-43u7afl3	381	11	attenuate	attenuate	VB
cord-342936-43u7afl3	381	12	the	the	DT
cord-342936-43u7afl3	381	13	activity	activity	NN
cord-342936-43u7afl3	381	14	of	of	IN
cord-342936-43u7afl3	381	15	the	the	DT
cord-342936-43u7afl3	381	16	CBA	CBA	NNP
cord-342936-43u7afl3	381	17	against	against	IN
cord-342936-43u7afl3	381	18	the	the	DT
cord-342936-43u7afl3	381	19	viral	viral	JJ
cord-342936-43u7afl3	381	20	carbohydrates	carbohydrate	NNS
cord-342936-43u7afl3	381	21	(	(	-LRB-
cord-342936-43u7afl3	381	22	making	make	VBG
cord-342936-43u7afl3	381	23	them	-PRON-	PRP
cord-342936-43u7afl3	381	24	less	less	JJR
cord-342936-43u7afl3	381	25	antivirally	antivirally	RB
cord-342936-43u7afl3	381	26	active	active	JJ
cord-342936-43u7afl3	381	27	)	)	-RRB-
cord-342936-43u7afl3	381	28	.	.	.
cord-342936-43u7afl3	382	1	It	-PRON-	PRP
cord-342936-43u7afl3	382	2	may	may	MD
cord-342936-43u7afl3	382	3	also	also	RB
cord-342936-43u7afl3	382	4	provoke	provoke	VB
cord-342936-43u7afl3	382	5	hyperreactivity	hyperreactivity	NN
cord-342936-43u7afl3	382	6	of	of	IN
cord-342936-43u7afl3	382	7	the	the	DT
cord-342936-43u7afl3	382	8	immune	immune	JJ
cord-342936-43u7afl3	382	9	system	system	NN
cord-342936-43u7afl3	382	10	,	,	,
cord-342936-43u7afl3	382	11	which	which	WDT
cord-342936-43u7afl3	382	12	would	would	MD
cord-342936-43u7afl3	382	13	necessitate	necessitate	VB
cord-342936-43u7afl3	382	14	premature	premature	JJ
cord-342936-43u7afl3	382	15	abrogation	abrogation	NN
cord-342936-43u7afl3	382	16	of	of	IN
cord-342936-43u7afl3	382	17	the	the	DT
cord-342936-43u7afl3	382	18	continued	continued	JJ
cord-342936-43u7afl3	382	19	administration	administration	NN
cord-342936-43u7afl3	382	20	of	of	IN
cord-342936-43u7afl3	382	21	the	the	DT
cord-342936-43u7afl3	382	22	CBA	CBA	NNP
cord-342936-43u7afl3	382	23	.	.	.
cord-342936-43u7afl3	383	1	Obviously	obviously	RB
cord-342936-43u7afl3	383	2	,	,	,
cord-342936-43u7afl3	383	3	lowmolecular	lowmolecular	JJ
cord-342936-43u7afl3	383	4	-	-	HYPH
cord-342936-43u7afl3	383	5	weight	weight	NN
cord-342936-43u7afl3	383	6	non	non	JJ
cord-342936-43u7afl3	383	7	-	-	JJ
cord-342936-43u7afl3	383	8	peptidic	peptidic	JJ
cord-342936-43u7afl3	383	9	CBAs	cba	NNS
cord-342936-43u7afl3	383	10	will	will	MD
cord-342936-43u7afl3	383	11	not	not	RB
cord-342936-43u7afl3	383	12	suffer	suffer	VB
cord-342936-43u7afl3	383	13	from	from	IN
cord-342936-43u7afl3	383	14	this	this	DT
cord-342936-43u7afl3	383	15	potential	potential	JJ
cord-342936-43u7afl3	383	16	drawback	drawback	NN
cord-342936-43u7afl3	383	17	.	.	.
cord-342936-43u7afl3	384	1	The	the	DT
cord-342936-43u7afl3	384	2	greatest	great	JJS
cord-342936-43u7afl3	384	3	concern	concern	NN
cord-342936-43u7afl3	384	4	,	,	,
cord-342936-43u7afl3	384	5	for	for	IN
cord-342936-43u7afl3	384	6	both	both	DT
cord-342936-43u7afl3	384	7	protein	protein	NN
cord-342936-43u7afl3	384	8	and	and	CC
cord-342936-43u7afl3	384	9	non	non	JJ
cord-342936-43u7afl3	384	10	-	-	JJ
cord-342936-43u7afl3	384	11	peptidic	peptidic	JJ
cord-342936-43u7afl3	384	12	CBAs	cba	NNS
cord-342936-43u7afl3	384	13	,	,	,
cord-342936-43u7afl3	384	14	is	be	VBZ
cord-342936-43u7afl3	384	15	the	the	DT
cord-342936-43u7afl3	384	16	degree	degree	NN
cord-342936-43u7afl3	384	17	of	of	IN
cord-342936-43u7afl3	384	18	selectivity	selectivity	NN
cord-342936-43u7afl3	384	19	they	-PRON-	PRP
cord-342936-43u7afl3	384	20	may	may	MD
cord-342936-43u7afl3	384	21	eventually	eventually	RB
cord-342936-43u7afl3	384	22	show	show	VB
cord-342936-43u7afl3	384	23	for	for	IN
cord-342936-43u7afl3	384	24	the	the	DT
cord-342936-43u7afl3	384	25	viral	viral	JJ
cord-342936-43u7afl3	384	26	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	384	27	-that	-that	WDT
cord-342936-43u7afl3	384	28	is	be	VBZ
cord-342936-43u7afl3	384	29	,	,	,
cord-342936-43u7afl3	384	30	their	-PRON-	PRP$
cord-342936-43u7afl3	384	31	potential	potential	NN
cord-342936-43u7afl3	384	32	to	to	TO
cord-342936-43u7afl3	384	33	discriminate	discriminate	VB
cord-342936-43u7afl3	384	34	between	between	IN
cord-342936-43u7afl3	384	35	pathogen	pathogen	NN
cord-342936-43u7afl3	384	36	(	(	-LRB-
cord-342936-43u7afl3	384	37	non	non	JJ
cord-342936-43u7afl3	384	38	-	-	JJ
cord-342936-43u7afl3	384	39	self	self	JJ
cord-342936-43u7afl3	384	40	)	)	-RRB-
cord-342936-43u7afl3	384	41	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	384	42	and	and	CC
cord-342936-43u7afl3	384	43	cellular	cellular	JJ
cord-342936-43u7afl3	384	44	(	(	-LRB-
cord-342936-43u7afl3	384	45	self	self	NN
cord-342936-43u7afl3	384	46	)	)	-RRB-
cord-342936-43u7afl3	384	47	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	384	48	.	.	.
cord-342936-43u7afl3	385	1	However	however	RB
cord-342936-43u7afl3	385	2	,	,	,
cord-342936-43u7afl3	385	3	the	the	DT
cord-342936-43u7afl3	385	4	HIV	HIV	NNP
cord-342936-43u7afl3	385	5	envelope	envelope	NN
cord-342936-43u7afl3	385	6	gp120	gp120	NNP
cord-342936-43u7afl3	385	7	carries	carry	VBZ
cord-342936-43u7afl3	385	8	a	a	DT
cord-342936-43u7afl3	385	9	higher	high	JJR
cord-342936-43u7afl3	385	10	proportion	proportion	NN
cord-342936-43u7afl3	385	11	of	of	IN
cord-342936-43u7afl3	385	12	high	high	JJ
cord-342936-43u7afl3	385	13	-	-	HYPH
cord-342936-43u7afl3	385	14	mannosetype	mannosetype	NN
cord-342936-43u7afl3	385	15	glycans	glycan	NNS
cord-342936-43u7afl3	385	16	than	than	IN
cord-342936-43u7afl3	385	17	do	do	VBP
cord-342936-43u7afl3	385	18	mammalian	mammalian	JJ
cord-342936-43u7afl3	385	19	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	385	20	87	87	CD
cord-342936-43u7afl3	385	21	.	.	.
cord-342936-43u7afl3	386	1	The	the	DT
cord-342936-43u7afl3	386	2	three	three	CD
cord-342936-43u7afl3	386	3	-	-	HYPH
cord-342936-43u7afl3	386	4	dimensional	dimensional	JJ
cord-342936-43u7afl3	386	5	configuration	configuration	NN
cord-342936-43u7afl3	386	6	of	of	IN
cord-342936-43u7afl3	386	7	the	the	DT
cord-342936-43u7afl3	386	8	glycans	glycan	NNS
cord-342936-43u7afl3	386	9	that	that	WDT
cord-342936-43u7afl3	386	10	are	be	VBP
cord-342936-43u7afl3	386	11	displayed	display	VBN
cord-342936-43u7afl3	386	12	on	on	IN
cord-342936-43u7afl3	386	13	the	the	DT
cord-342936-43u7afl3	386	14	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	386	15	of	of	IN
cord-342936-43u7afl3	386	16	the	the	DT
cord-342936-43u7afl3	386	17	pathogen	pathogen	NN
cord-342936-43u7afl3	386	18	has	have	VBZ
cord-342936-43u7afl3	386	19	been	be	VBN
cord-342936-43u7afl3	386	20	shown	show	VBN
cord-342936-43u7afl3	386	21	to	to	TO
cord-342936-43u7afl3	386	22	be	be	VB
cord-342936-43u7afl3	386	23	important	important	JJ
cord-342936-43u7afl3	386	24	,	,	,
cord-342936-43u7afl3	386	25	which	which	WDT
cord-342936-43u7afl3	386	26	may	may	MD
cord-342936-43u7afl3	386	27	help	help	VB
cord-342936-43u7afl3	386	28	the	the	DT
cord-342936-43u7afl3	386	29	CBA	CBA	NNP
cord-342936-43u7afl3	386	30	to	to	TO
cord-342936-43u7afl3	386	31	distinguish	distinguish	VB
cord-342936-43u7afl3	386	32	between	between	IN
cord-342936-43u7afl3	386	33	'	'	``
cord-342936-43u7afl3	386	34	non	non	JJ
cord-342936-43u7afl3	386	35	-	-	JJ
cord-342936-43u7afl3	386	36	self	self	JJ
cord-342936-43u7afl3	386	37	'	'	''
cord-342936-43u7afl3	386	38	glycans	glycan	NNS
cord-342936-43u7afl3	386	39	of	of	IN
cord-342936-43u7afl3	386	40	the	the	DT
cord-342936-43u7afl3	386	41	pathogen	pathogen	NN
cord-342936-43u7afl3	386	42	and	and	CC
cord-342936-43u7afl3	386	43	'	'	``
cord-342936-43u7afl3	386	44	self	self	NN
cord-342936-43u7afl3	386	45	'	'	''
cord-342936-43u7afl3	386	46	glycans	glycan	NNS
cord-342936-43u7afl3	386	47	of	of	IN
cord-342936-43u7afl3	386	48	the	the	DT
cord-342936-43u7afl3	386	49	host	host	NN
cord-342936-43u7afl3	386	50	.	.	.
cord-342936-43u7afl3	387	1	High	high	JJ
cord-342936-43u7afl3	387	2	-	-	HYPH
cord-342936-43u7afl3	387	3	mannose	mannose	NN
cord-342936-43u7afl3	387	4	-	-	HYPH
cord-342936-43u7afl3	387	5	type	type	NN
cord-342936-43u7afl3	387	6	glycans	glycan	NNS
cord-342936-43u7afl3	387	7	contain	contain	VBP
cord-342936-43u7afl3	387	8	terminal	terminal	JJ
cord-342936-43u7afl3	387	9	α(1,2)-mannose	α(1,2)-mannose	ADD
cord-342936-43u7afl3	387	10	oligomers	oligomer	NNS
cord-342936-43u7afl3	387	11	that	that	WDT
cord-342936-43u7afl3	387	12	are	be	VBP
cord-342936-43u7afl3	387	13	rare	rare	JJ
cord-342936-43u7afl3	387	14	on	on	IN
cord-342936-43u7afl3	387	15	glycans	glycan	NNS
cord-342936-43u7afl3	387	16	of	of	IN
cord-342936-43u7afl3	387	17	mammalian	mammalian	JJ
cord-342936-43u7afl3	387	18	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	387	19	.	.	.
cord-342936-43u7afl3	388	1	In	in	IN
cord-342936-43u7afl3	388	2	fact	fact	NN
cord-342936-43u7afl3	388	3	,	,	,
cord-342936-43u7afl3	388	4	MBL	MBL	NNP
cord-342936-43u7afl3	388	5	and	and	CC
cord-342936-43u7afl3	388	6	DC	DC	NNP
cord-342936-43u7afl3	388	7	-	-	HYPH
cord-342936-43u7afl3	388	8	SIGN	SIGN	NNP
cord-342936-43u7afl3	388	9	can	can	MD
cord-342936-43u7afl3	388	10	distinguish	distinguish	VB
cord-342936-43u7afl3	388	11	between	between	IN
cord-342936-43u7afl3	388	12	pathogen	pathogen	NN
cord-342936-43u7afl3	388	13	-	-	HYPH
cord-342936-43u7afl3	388	14	derived	derive	VBN
cord-342936-43u7afl3	388	15	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	388	16	and	and	CC
cord-342936-43u7afl3	388	17	cellular	cellular	JJ
cord-342936-43u7afl3	388	18	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	388	19	,	,	,
cord-342936-43u7afl3	388	20	enabling	enable	VBG
cord-342936-43u7afl3	388	21	a	a	DT
cord-342936-43u7afl3	388	22	selective	selective	JJ
cord-342936-43u7afl3	388	23	elimination	elimination	NN
cord-342936-43u7afl3	388	24	of	of	IN
cord-342936-43u7afl3	388	25	the	the	DT
cord-342936-43u7afl3	388	26	pathogen	pathogen	NN
cord-342936-43u7afl3	388	27	through	through	IN
cord-342936-43u7afl3	388	28	specific	specific	JJ
cord-342936-43u7afl3	388	29	interaction	interaction	NN
cord-342936-43u7afl3	388	30	with	with	IN
cord-342936-43u7afl3	388	31	its	-PRON-	PRP$
cord-342936-43u7afl3	388	32	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	388	33	configuration	configuration	NN
cord-342936-43u7afl3	388	34	65	65	CD
cord-342936-43u7afl3	388	35	,	,	,
cord-342936-43u7afl3	388	36	119	119	CD
cord-342936-43u7afl3	388	37	.	.	.
cord-342936-43u7afl3	389	1	It	-PRON-	PRP
cord-342936-43u7afl3	389	2	is	be	VBZ
cord-342936-43u7afl3	389	3	also	also	RB
cord-342936-43u7afl3	389	4	important	important	JJ
cord-342936-43u7afl3	389	5	that	that	IN
cord-342936-43u7afl3	389	6	the	the	DT
cord-342936-43u7afl3	389	7	CBA	CBA	NNP
cord-342936-43u7afl3	389	8	can	can	MD
cord-342936-43u7afl3	389	9	discriminate	discriminate	VB
cord-342936-43u7afl3	389	10	between	between	IN
cord-342936-43u7afl3	389	11	the	the	DT
cord-342936-43u7afl3	389	12	glycans	glycan	NNS
cord-342936-43u7afl3	389	13	present	present	JJ
cord-342936-43u7afl3	389	14	on	on	IN
cord-342936-43u7afl3	389	15	commensal	commensal	JJ
cord-342936-43u7afl3	389	16	bacteria	bacteria	NNS
cord-342936-43u7afl3	389	17	and	and	CC
cord-342936-43u7afl3	389	18	the	the	DT
cord-342936-43u7afl3	389	19	glycans	glycan	NNS
cord-342936-43u7afl3	389	20	that	that	WDT
cord-342936-43u7afl3	389	21	must	must	MD
cord-342936-43u7afl3	389	22	be	be	VB
cord-342936-43u7afl3	389	23	targeted	target	VBN
cord-342936-43u7afl3	389	24	on	on	IN
cord-342936-43u7afl3	389	25	the	the	DT
cord-342936-43u7afl3	389	26	viral	viral	JJ
cord-342936-43u7afl3	389	27	-	-	HYPH
cord-342936-43u7afl3	389	28	envelope	envelope	NN
cord-342936-43u7afl3	389	29	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	389	30	.	.	.
cord-342936-43u7afl3	390	1	It	-PRON-	PRP
cord-342936-43u7afl3	390	2	will	will	MD
cord-342936-43u7afl3	390	3	be	be	VB
cord-342936-43u7afl3	390	4	a	a	DT
cord-342936-43u7afl3	390	5	challenging	challenging	JJ
cord-342936-43u7afl3	390	6	goal	goal	NN
cord-342936-43u7afl3	390	7	,	,	,
cord-342936-43u7afl3	390	8	but	but	CC
cord-342936-43u7afl3	390	9	one	one	CD
cord-342936-43u7afl3	390	10	,	,	,
cord-342936-43u7afl3	390	11	I	-PRON-	PRP
cord-342936-43u7afl3	390	12	believe	believe	VBP
cord-342936-43u7afl3	390	13	,	,	,
cord-342936-43u7afl3	390	14	which	which	WDT
cord-342936-43u7afl3	390	15	is	be	VBZ
cord-342936-43u7afl3	390	16	achievable	achievable	JJ
cord-342936-43u7afl3	390	17	,	,	,
cord-342936-43u7afl3	390	18	to	to	TO
cord-342936-43u7afl3	390	19	discover	discover	VB
cord-342936-43u7afl3	390	20	or	or	CC
cord-342936-43u7afl3	390	21	design	design	VB
cord-342936-43u7afl3	390	22	CBAs	cba	NNS
cord-342936-43u7afl3	390	23	that	that	WDT
cord-342936-43u7afl3	390	24	show	show	VBP
cord-342936-43u7afl3	390	25	a	a	DT
cord-342936-43u7afl3	390	26	marked	marked	JJ
cord-342936-43u7afl3	390	27	degree	degree	NN
cord-342936-43u7afl3	390	28	of	of	IN
cord-342936-43u7afl3	390	29	discriminating	discriminate	VBG
cord-342936-43u7afl3	390	30	selectivity	selectivity	NN
cord-342936-43u7afl3	390	31	between	between	IN
cord-342936-43u7afl3	390	32	pathogen	pathogen	NN
cord-342936-43u7afl3	390	33	glycans	glycan	NNS
cord-342936-43u7afl3	390	34	and	and	CC
cord-342936-43u7afl3	390	35	the	the	DT
cord-342936-43u7afl3	390	36	glycans	glycan	NNS
cord-342936-43u7afl3	390	37	of	of	IN
cord-342936-43u7afl3	390	38	the	the	DT
cord-342936-43u7afl3	390	39	host	host	NN
cord-342936-43u7afl3	390	40	,	,	,
cord-342936-43u7afl3	390	41	including	include	VBG
cord-342936-43u7afl3	390	42	the	the	DT
cord-342936-43u7afl3	390	43	glycans	glycan	NNS
cord-342936-43u7afl3	390	44	of	of	IN
cord-342936-43u7afl3	390	45	commensal	commensal	JJ
cord-342936-43u7afl3	390	46	bacteria	bacteria	NNS
cord-342936-43u7afl3	390	47	.	.	.
cord-342936-43u7afl3	391	1	Although	although	IN
cord-342936-43u7afl3	391	2	most	most	JJS
cord-342936-43u7afl3	391	3	CBAs	cba	NNS
cord-342936-43u7afl3	391	4	are	be	VBP
cord-342936-43u7afl3	391	5	proteins	protein	NNS
cord-342936-43u7afl3	391	6	(	(	-LRB-
cord-342936-43u7afl3	391	7	such	such	JJ
cord-342936-43u7afl3	391	8	as	as	IN
cord-342936-43u7afl3	391	9	prokaryotic	prokaryotic	JJ
cord-342936-43u7afl3	391	10	and	and	CC
cord-342936-43u7afl3	391	11	plant	plant	NN
cord-342936-43u7afl3	391	12	-	-	HYPH
cord-342936-43u7afl3	391	13	lectin	lectin	NN
cord-342936-43u7afl3	391	14	CBAs	cba	NNS
cord-342936-43u7afl3	391	15	)	)	-RRB-
cord-342936-43u7afl3	391	16	,	,	,
cord-342936-43u7afl3	391	17	the	the	DT
cord-342936-43u7afl3	391	18	demonstration	demonstration	NN
cord-342936-43u7afl3	391	19	that	that	IN
cord-342936-43u7afl3	391	20	small	small	JJ
cord-342936-43u7afl3	391	21	-	-	HYPH
cord-342936-43u7afl3	391	22	size	size	NN
cord-342936-43u7afl3	391	23	nonpeptidic	nonpeptidic	NNP
cord-342936-43u7afl3	391	24	CBAs	CBAs	NNPS
cord-342936-43u7afl3	391	25	(	(	-LRB-
cord-342936-43u7afl3	391	26	that	that	RB
cord-342936-43u7afl3	391	27	is	is	RB
cord-342936-43u7afl3	391	28	,	,	,
cord-342936-43u7afl3	391	29	those	those	DT
cord-342936-43u7afl3	391	30	with	with	IN
cord-342936-43u7afl3	391	31	a	a	DT
cord-342936-43u7afl3	391	32	molecular	molecular	JJ
cord-342936-43u7afl3	391	33	weight	weight	NN
cord-342936-43u7afl3	391	34	of	of	IN
cord-342936-43u7afl3	391	35	less	less	JJR
cord-342936-43u7afl3	391	36	than	than	IN
cord-342936-43u7afl3	391	37	1	1	CD
cord-342936-43u7afl3	391	38	-	-	SYM
cord-342936-43u7afl3	391	39	2	2	CD
cord-342936-43u7afl3	391	40	kDa	kDa	NNS
cord-342936-43u7afl3	391	41	)	)	-RRB-
cord-342936-43u7afl3	391	42	(	(	-LRB-
cord-342936-43u7afl3	391	43	FIG	FIG	NNP
cord-342936-43u7afl3	391	44	.	.	.
cord-342936-43u7afl3	391	45	3	3	LS
cord-342936-43u7afl3	391	46	)	)	-RRB-
cord-342936-43u7afl3	391	47	can	can	MD
cord-342936-43u7afl3	391	48	efficiently	efficiently	RB
cord-342936-43u7afl3	391	49	suppress	suppress	VB
cord-342936-43u7afl3	391	50	viral	viral	JJ
cord-342936-43u7afl3	391	51	and	and	CC
cord-342936-43u7afl3	391	52	fungal	fungal	JJ
cord-342936-43u7afl3	391	53	infections	infection	NNS
cord-342936-43u7afl3	391	54	makes	make	VBZ
cord-342936-43u7afl3	391	55	this	this	DT
cord-342936-43u7afl3	391	56	class	class	NN
cord-342936-43u7afl3	391	57	of	of	IN
cord-342936-43u7afl3	391	58	compounds	compound	NNS
cord-342936-43u7afl3	391	59	a	a	DT
cord-342936-43u7afl3	391	60	feasible	feasible	JJ
cord-342936-43u7afl3	391	61	and	and	CC
cord-342936-43u7afl3	391	62	realistic	realistic	JJ
cord-342936-43u7afl3	391	63	tool	tool	NN
cord-342936-43u7afl3	391	64	for	for	IN
cord-342936-43u7afl3	391	65	pathogen	pathogen	NN
cord-342936-43u7afl3	391	66	inhibition	inhibition	NN
cord-342936-43u7afl3	391	67	in	in	IN
cord-342936-43u7afl3	391	68	the	the	DT
cord-342936-43u7afl3	391	69	clinical	clinical	JJ
cord-342936-43u7afl3	391	70	setting	setting	NN
cord-342936-43u7afl3	391	71	.	.	.
cord-342936-43u7afl3	392	1	However	however	RB
cord-342936-43u7afl3	392	2	,	,	,
cord-342936-43u7afl3	392	3	much	much	JJ
cord-342936-43u7afl3	392	4	work	work	NN
cord-342936-43u7afl3	392	5	still	still	RB
cord-342936-43u7afl3	392	6	has	have	VBZ
cord-342936-43u7afl3	392	7	to	to	TO
cord-342936-43u7afl3	392	8	be	be	VB
cord-342936-43u7afl3	392	9	done	do	VBN
cord-342936-43u7afl3	392	10	,	,	,
cord-342936-43u7afl3	392	11	and	and	CC
cord-342936-43u7afl3	392	12	more	more	RBR
cord-342936-43u7afl3	392	13	synthetic	synthetic	JJ
cord-342936-43u7afl3	392	14	low	low	JJ
cord-342936-43u7afl3	392	15	-	-	HYPH
cord-342936-43u7afl3	392	16	molecular	molecular	JJ
cord-342936-43u7afl3	392	17	-	-	HYPH
cord-342936-43u7afl3	392	18	weight	weight	NN
cord-342936-43u7afl3	392	19	compounds	compound	NNS
cord-342936-43u7afl3	392	20	need	need	VBP
cord-342936-43u7afl3	392	21	to	to	TO
cord-342936-43u7afl3	392	22	be	be	VB
cord-342936-43u7afl3	392	23	designed	design	VBN
cord-342936-43u7afl3	392	24	or	or	CC
cord-342936-43u7afl3	392	25	discovered	discover	VBN
cord-342936-43u7afl3	392	26	to	to	TO
cord-342936-43u7afl3	392	27	enable	enable	VB
cord-342936-43u7afl3	392	28	the	the	DT
cord-342936-43u7afl3	392	29	efficient	efficient	JJ
cord-342936-43u7afl3	392	30	exploration	exploration	NN
cord-342936-43u7afl3	392	31	of	of	IN
cord-342936-43u7afl3	392	32	this	this	DT
cord-342936-43u7afl3	392	33	novel	novel	JJ
cord-342936-43u7afl3	392	34	functional	functional	JJ
cord-342936-43u7afl3	392	35	class	class	NN
cord-342936-43u7afl3	392	36	of	of	IN
cord-342936-43u7afl3	392	37	antivirals	antiviral	NNS
cord-342936-43u7afl3	392	38	.	.	.
cord-342936-43u7afl3	393	1	This	this	DT
cord-342936-43u7afl3	393	2	is	be	VBZ
cord-342936-43u7afl3	393	3	the	the	DT
cord-342936-43u7afl3	393	4	only	only	JJ
cord-342936-43u7afl3	393	5	way	way	NN
cord-342936-43u7afl3	393	6	to	to	TO
cord-342936-43u7afl3	393	7	enable	enable	VB
cord-342936-43u7afl3	393	8	a	a	DT
cord-342936-43u7afl3	393	9	careful	careful	JJ
cord-342936-43u7afl3	393	10	and	and	CC
cord-342936-43u7afl3	393	11	rational	rational	JJ
cord-342936-43u7afl3	393	12	selection	selection	NN
cord-342936-43u7afl3	393	13	of	of	IN
cord-342936-43u7afl3	393	14	CBAs	cba	NNS
cord-342936-43u7afl3	393	15	that	that	WDT
cord-342936-43u7afl3	393	16	have	have	VBP
cord-342936-43u7afl3	393	17	a	a	DT
cord-342936-43u7afl3	393	18	high	high	JJ
cord-342936-43u7afl3	393	19	specificity	specificity	NN
cord-342936-43u7afl3	393	20	and	and	CC
cord-342936-43u7afl3	393	21	selectivity	selectivity	NN
cord-342936-43u7afl3	393	22	for	for	IN
cord-342936-43u7afl3	393	23	the	the	DT
cord-342936-43u7afl3	393	24	pathogen	pathogen	NN
cord-342936-43u7afl3	393	25	and	and	CC
cord-342936-43u7afl3	393	26	few	few	JJ
cord-342936-43u7afl3	393	27	,	,	,
cord-342936-43u7afl3	393	28	if	if	IN
cord-342936-43u7afl3	393	29	any	any	DT
cord-342936-43u7afl3	393	30	,	,	,
cord-342936-43u7afl3	393	31	side	side	JJ
cord-342936-43u7afl3	393	32	effects	effect	NNS
cord-342936-43u7afl3	393	33	in	in	IN
cord-342936-43u7afl3	393	34	the	the	DT
cord-342936-43u7afl3	393	35	host	host	NN
cord-342936-43u7afl3	393	36	,	,	,
cord-342936-43u7afl3	393	37	especially	especially	RB
cord-342936-43u7afl3	393	38	when	when	WRB
cord-342936-43u7afl3	393	39	included	include	VBN
cord-342936-43u7afl3	393	40	in	in	IN
cord-342936-43u7afl3	393	41	long	long	JJ
cord-342936-43u7afl3	393	42	-	-	HYPH
cord-342936-43u7afl3	393	43	term	term	NN
cord-342936-43u7afl3	393	44	treatment	treatment	NN
cord-342936-43u7afl3	393	45	modalities	modality	NNS
cord-342936-43u7afl3	393	46	.	.	.
cord-342936-43u7afl3	394	1	Several	several	JJ
cord-342936-43u7afl3	394	2	synthetic	synthetic	JJ
cord-342936-43u7afl3	394	3	CBA	CBA	NNP
cord-342936-43u7afl3	394	4	lead	lead	NN
cord-342936-43u7afl3	394	5	compounds	compound	NNS
cord-342936-43u7afl3	394	6	are	be	VBP
cord-342936-43u7afl3	394	7	already	already	RB
cord-342936-43u7afl3	394	8	available	available	JJ
cord-342936-43u7afl3	394	9	61	61	CD
cord-342936-43u7afl3	394	10	,	,	,
cord-342936-43u7afl3	394	11	62	62	CD
cord-342936-43u7afl3	394	12	,	,	,
cord-342936-43u7afl3	394	13	which	which	WDT
cord-342936-43u7afl3	394	14	should	should	MD
cord-342936-43u7afl3	394	15	trigger	trigger	VB
cord-342936-43u7afl3	394	16	the	the	DT
cord-342936-43u7afl3	394	17	synthesis	synthesis	NN
cord-342936-43u7afl3	394	18	of	of	IN
cord-342936-43u7afl3	394	19	structurally	structurally	RB
cord-342936-43u7afl3	394	20	related	relate	VBN
cord-342936-43u7afl3	394	21	compounds	compound	NNS
cord-342936-43u7afl3	394	22	,	,	,
cord-342936-43u7afl3	394	23	by	by	IN
cord-342936-43u7afl3	394	24	organic	organic	JJ
cord-342936-43u7afl3	394	25	and	and	CC
cord-342936-43u7afl3	394	26	medicinal	medicinal	JJ
cord-342936-43u7afl3	394	27	chemists	chemist	NNS
cord-342936-43u7afl3	394	28	,	,	,
cord-342936-43u7afl3	394	29	to	to	TO
cord-342936-43u7afl3	394	30	allow	allow	VB
cord-342936-43u7afl3	394	31	extensive	extensive	JJ
cord-342936-43u7afl3	394	32	structure	structure	NN
cord-342936-43u7afl3	394	33	-	-	HYPH
cord-342936-43u7afl3	394	34	activity	activity	NN
cord-342936-43u7afl3	394	35	relationship	relationship	NN
cord-342936-43u7afl3	394	36	studies	study	NNS
cord-342936-43u7afl3	394	37	.	.	.
cord-342936-43u7afl3	395	1	Such	such	JJ
cord-342936-43u7afl3	395	2	investigations	investigation	NNS
cord-342936-43u7afl3	395	3	could	could	MD
cord-342936-43u7afl3	395	4	indicate	indicate	VB
cord-342936-43u7afl3	395	5	which	which	WDT
cord-342936-43u7afl3	395	6	CBAs	cba	NNS
cord-342936-43u7afl3	395	7	are	be	VBP
cord-342936-43u7afl3	395	8	likely	likely	JJ
cord-342936-43u7afl3	395	9	to	to	TO
cord-342936-43u7afl3	395	10	be	be	VB
cord-342936-43u7afl3	395	11	the	the	DT
cord-342936-43u7afl3	395	12	most	most	RBS
cord-342936-43u7afl3	395	13	potent	potent	JJ
cord-342936-43u7afl3	395	14	and	and	CC
cord-342936-43u7afl3	395	15	selective	selective	JJ
cord-342936-43u7afl3	395	16	candidates	candidate	NNS
cord-342936-43u7afl3	395	17	for	for	IN
cord-342936-43u7afl3	395	18	further	further	JJ
cord-342936-43u7afl3	395	19	pre	pre	JJ
cord-342936-43u7afl3	395	20	-	-	JJ
cord-342936-43u7afl3	395	21	clinical	clinical	JJ
cord-342936-43u7afl3	395	22	investigations	investigation	NNS
cord-342936-43u7afl3	395	23	.	.	.
cord-342936-43u7afl3	396	1	Glycans	glycan	NNS
cord-342936-43u7afl3	396	2	on	on	IN
cord-342936-43u7afl3	396	3	the	the	DT
cord-342936-43u7afl3	396	4	envelope	envelope	NN
cord-342936-43u7afl3	396	5	or	or	CC
cord-342936-43u7afl3	396	6	cell	cell	NN
cord-342936-43u7afl3	396	7	wall	wall	NN
cord-342936-43u7afl3	396	8	of	of	IN
cord-342936-43u7afl3	396	9	pathogens	pathogen	NNS
cord-342936-43u7afl3	396	10	often	often	RB
cord-342936-43u7afl3	396	11	seem	seem	VBP
cord-342936-43u7afl3	396	12	to	to	TO
cord-342936-43u7afl3	396	13	have	have	VB
cord-342936-43u7afl3	396	14	similar	similar	JJ
cord-342936-43u7afl3	396	15	functional	functional	JJ
cord-342936-43u7afl3	396	16	roles	role	NNS
cord-342936-43u7afl3	396	17	,	,	,
cord-342936-43u7afl3	396	18	such	such	JJ
cord-342936-43u7afl3	396	19	as	as	IN
cord-342936-43u7afl3	396	20	escape	escape	NN
cord-342936-43u7afl3	396	21	from	from	IN
cord-342936-43u7afl3	396	22	recognition	recognition	NN
cord-342936-43u7afl3	396	23	by	by	IN
cord-342936-43u7afl3	396	24	the	the	DT
cord-342936-43u7afl3	396	25	immune	immune	JJ
cord-342936-43u7afl3	396	26	system	system	NN
cord-342936-43u7afl3	396	27	or	or	CC
cord-342936-43u7afl3	396	28	recognition	recognition	NN
cord-342936-43u7afl3	396	29	by	by	IN
cord-342936-43u7afl3	396	30	lectins	lectin	NNS
cord-342936-43u7afl3	396	31	from	from	IN
cord-342936-43u7afl3	396	32	the	the	DT
cord-342936-43u7afl3	396	33	innate	innate	JJ
cord-342936-43u7afl3	396	34	immune	immune	JJ
cord-342936-43u7afl3	396	35	system	system	NN
cord-342936-43u7afl3	396	36	,	,	,
cord-342936-43u7afl3	396	37	that	that	WDT
cord-342936-43u7afl3	396	38	allow	allow	VBP
cord-342936-43u7afl3	396	39	efficient	efficient	JJ
cord-342936-43u7afl3	396	40	transmission	transmission	NN
cord-342936-43u7afl3	396	41	of	of	IN
cord-342936-43u7afl3	396	42	the	the	DT
cord-342936-43u7afl3	396	43	pathogen	pathogen	NN
cord-342936-43u7afl3	396	44	.	.	.
cord-342936-43u7afl3	397	1	The	the	DT
cord-342936-43u7afl3	397	2	concept	concept	NN
cord-342936-43u7afl3	397	3	of	of	IN
cord-342936-43u7afl3	397	4	interfering	interfere	VBG
cord-342936-43u7afl3	397	5	with	with	IN
cord-342936-43u7afl3	397	6	and/or	and/or	CC
cord-342936-43u7afl3	397	7	abrogating	abrogate	VBG
cord-342936-43u7afl3	397	8	these	these	DT
cord-342936-43u7afl3	397	9	protective	protective	JJ
cord-342936-43u7afl3	397	10	mechanisms	mechanism	NNS
cord-342936-43u7afl3	397	11	should	should	MD
cord-342936-43u7afl3	397	12	,	,	,
cord-342936-43u7afl3	397	13	therefore	therefore	RB
cord-342936-43u7afl3	397	14	,	,	,
cord-342936-43u7afl3	397	15	be	be	VB
cord-342936-43u7afl3	397	16	put	put	VBN
cord-342936-43u7afl3	397	17	into	into	IN
cord-342936-43u7afl3	397	18	a	a	DT
cord-342936-43u7afl3	397	19	broader	broad	JJR
cord-342936-43u7afl3	397	20	context	context	NN
cord-342936-43u7afl3	397	21	than	than	IN
cord-342936-43u7afl3	397	22	solely	solely	RB
cord-342936-43u7afl3	397	23	antiviral	antiviral	JJ
cord-342936-43u7afl3	397	24	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	397	25	intervention	intervention	NN
cord-342936-43u7afl3	397	26	.	.	.
cord-342936-43u7afl3	398	1	Many	many	JJ
cord-342936-43u7afl3	398	2	different	different	JJ
cord-342936-43u7afl3	398	3	microorganisms	microorganism	NNS
cord-342936-43u7afl3	398	4	other	other	JJ
cord-342936-43u7afl3	398	5	than	than	IN
cord-342936-43u7afl3	398	6	viruses	virus	NNS
cord-342936-43u7afl3	398	7	(	(	-LRB-
cord-342936-43u7afl3	398	8	such	such	JJ
cord-342936-43u7afl3	398	9	as	as	IN
cord-342936-43u7afl3	398	10	certain	certain	JJ
cord-342936-43u7afl3	398	11	bacteria	bacteria	NNS
cord-342936-43u7afl3	398	12	,	,	,
cord-342936-43u7afl3	398	13	fungi	fungus	NNS
cord-342936-43u7afl3	398	14	,	,	,
cord-342936-43u7afl3	398	15	yeasts	yeast	NNS
cord-342936-43u7afl3	398	16	and	and	CC
cord-342936-43u7afl3	398	17	parasites	parasite	NNS
cord-342936-43u7afl3	398	18	)	)	-RRB-
cord-342936-43u7afl3	398	19	should	should	MD
cord-342936-43u7afl3	398	20	be	be	VB
cord-342936-43u7afl3	398	21	thoroughly	thoroughly	RB
cord-342936-43u7afl3	398	22	investigated	investigate	VBN
cord-342936-43u7afl3	398	23	for	for	IN
cord-342936-43u7afl3	398	24	their	-PRON-	PRP$
cord-342936-43u7afl3	398	25	potential	potential	JJ
cord-342936-43u7afl3	398	26	interactions	interaction	NNS
cord-342936-43u7afl3	398	27	with	with	IN
cord-342936-43u7afl3	398	28	CBAs	cba	NNS
cord-342936-43u7afl3	398	29	.	.	.
cord-342936-43u7afl3	399	1	However	however	RB
cord-342936-43u7afl3	399	2	,	,	,
cord-342936-43u7afl3	399	3	care	care	NN
cord-342936-43u7afl3	399	4	should	should	MD
cord-342936-43u7afl3	399	5	be	be	VB
cord-342936-43u7afl3	399	6	taken	take	VBN
cord-342936-43u7afl3	399	7	to	to	TO
cord-342936-43u7afl3	399	8	ensure	ensure	VB
cord-342936-43u7afl3	399	9	that	that	IN
cord-342936-43u7afl3	399	10	those	those	DT
cord-342936-43u7afl3	399	11	microorganisms	microorganism	NNS
cord-342936-43u7afl3	399	12	that	that	WDT
cord-342936-43u7afl3	399	13	have	have	VBP
cord-342936-43u7afl3	399	14	a	a	DT
cord-342936-43u7afl3	399	15	pivotal	pivotal	JJ
cord-342936-43u7afl3	399	16	role	role	NN
cord-342936-43u7afl3	399	17	in	in	IN
cord-342936-43u7afl3	399	18	maintaining	maintain	VBG
cord-342936-43u7afl3	399	19	the	the	DT
cord-342936-43u7afl3	399	20	homeostasis	homeostasis	NN
cord-342936-43u7afl3	399	21	of	of	IN
cord-342936-43u7afl3	399	22	human	human	JJ
cord-342936-43u7afl3	399	23	functions	function	NNS
cord-342936-43u7afl3	399	24	,	,	,
cord-342936-43u7afl3	399	25	such	such	JJ
cord-342936-43u7afl3	399	26	as	as	IN
cord-342936-43u7afl3	399	27	non	non	JJ
cord-342936-43u7afl3	399	28	-	-	JJ
cord-342936-43u7afl3	399	29	pathogenic	pathogenic	JJ
cord-342936-43u7afl3	399	30	lactobacilli	lactobacillus	NNS
cord-342936-43u7afl3	399	31	in	in	IN
cord-342936-43u7afl3	399	32	the	the	DT
cord-342936-43u7afl3	399	33	vaginal	vaginal	JJ
cord-342936-43u7afl3	399	34	environment	environment	NN
cord-342936-43u7afl3	399	35	or	or	CC
cord-342936-43u7afl3	399	36	commensal	commensal	JJ
cord-342936-43u7afl3	399	37	bacteria	bacteria	NNS
cord-342936-43u7afl3	399	38	in	in	IN
cord-342936-43u7afl3	399	39	the	the	DT
cord-342936-43u7afl3	399	40	intestine	intestine	NN
cord-342936-43u7afl3	399	41	,	,	,
cord-342936-43u7afl3	399	42	are	be	VBP
cord-342936-43u7afl3	399	43	not	not	RB
cord-342936-43u7afl3	399	44	negatively	negatively	RB
cord-342936-43u7afl3	399	45	affected	affect	VBN
cord-342936-43u7afl3	399	46	by	by	IN
cord-342936-43u7afl3	399	47	the	the	DT
cord-342936-43u7afl3	399	48	CBA	CBA	NNP
cord-342936-43u7afl3	399	49	.	.	.
cord-342936-43u7afl3	400	1	Including	include	VBG
cord-342936-43u7afl3	400	2	such	such	JJ
cord-342936-43u7afl3	400	3	bacterial	bacterial	JJ
cord-342936-43u7afl3	400	4	strains	strain	NNS
cord-342936-43u7afl3	400	5	in	in	IN
cord-342936-43u7afl3	400	6	the	the	DT
cord-342936-43u7afl3	400	7	screening	screening	NN
cord-342936-43u7afl3	400	8	of	of	IN
cord-342936-43u7afl3	400	9	CBAs	cba	NNS
cord-342936-43u7afl3	400	10	may	may	MD
cord-342936-43u7afl3	400	11	allow	allow	VB
cord-342936-43u7afl3	400	12	selection	selection	NN
cord-342936-43u7afl3	400	13	of	of	IN
cord-342936-43u7afl3	400	14	the	the	DT
cord-342936-43u7afl3	400	15	highest	high	JJS
cord-342936-43u7afl3	400	16	-	-	HYPH
cord-342936-43u7afl3	400	17	possible	possible	JJ
cord-342936-43u7afl3	400	18	pathogen	pathogen	NN
cord-342936-43u7afl3	400	19	-	-	HYPH
cord-342936-43u7afl3	400	20	selective	selective	JJ
cord-342936-43u7afl3	400	21	and	and	CC
cord-342936-43u7afl3	400	22	specific	specific	JJ
cord-342936-43u7afl3	400	23	CBAs	cba	NNS
cord-342936-43u7afl3	400	24	in	in	IN
cord-342936-43u7afl3	400	25	the	the	DT
cord-342936-43u7afl3	400	26	early	early	JJ
cord-342936-43u7afl3	400	27	stages	stage	NNS
cord-342936-43u7afl3	400	28	of	of	IN
cord-342936-43u7afl3	400	29	drug	drug	NN
cord-342936-43u7afl3	400	30	development	development	NN
cord-342936-43u7afl3	400	31	.	.	.
cord-342936-43u7afl3	401	1	CBAs	cba	NNS
cord-342936-43u7afl3	401	2	should	should	MD
cord-342936-43u7afl3	401	3	be	be	VB
cord-342936-43u7afl3	401	4	considered	consider	VBN
cord-342936-43u7afl3	401	5	to	to	TO
cord-342936-43u7afl3	401	6	be	be	VB
cord-342936-43u7afl3	401	7	valuable	valuable	JJ
cord-342936-43u7afl3	401	8	agents	agent	NNS
cord-342936-43u7afl3	401	9	in	in	IN
cord-342936-43u7afl3	401	10	their	-PRON-	PRP$
cord-342936-43u7afl3	401	11	own	own	JJ
cord-342936-43u7afl3	401	12	right	right	NN
cord-342936-43u7afl3	401	13	,	,	,
cord-342936-43u7afl3	401	14	directly	directly	RB
cord-342936-43u7afl3	401	15	suppressing	suppress	VBG
cord-342936-43u7afl3	401	16	or	or	CC
cord-342936-43u7afl3	401	17	preventing	prevent	VBG
cord-342936-43u7afl3	401	18	pathogen	pathogen	NN
cord-342936-43u7afl3	401	19	infection	infection	NN
cord-342936-43u7afl3	401	20	in	in	IN
cord-342936-43u7afl3	401	21	the	the	DT
cord-342936-43u7afl3	401	22	host	host	NN
cord-342936-43u7afl3	401	23	(	(	-LRB-
cord-342936-43u7afl3	401	24	FIG	FIG	NNP
cord-342936-43u7afl3	401	25	.	.	.
cord-342936-43u7afl3	401	26	1	1	CD
cord-342936-43u7afl3	401	27	)	)	-RRB-
cord-342936-43u7afl3	401	28	.	.	.
cord-342936-43u7afl3	402	1	However	however	RB
cord-342936-43u7afl3	402	2	,	,	,
cord-342936-43u7afl3	402	3	as	as	IN
cord-342936-43u7afl3	402	4	they	-PRON-	PRP
cord-342936-43u7afl3	402	5	can	can	MD
cord-342936-43u7afl3	402	6	force	force	VB
cord-342936-43u7afl3	402	7	the	the	DT
cord-342936-43u7afl3	402	8	pathogen	pathogen	NN
cord-342936-43u7afl3	402	9	to	to	TO
cord-342936-43u7afl3	402	10	mutate	mutate	VB
cord-342936-43u7afl3	402	11	(	(	-LRB-
cord-342936-43u7afl3	402	12	or	or	CC
cord-342936-43u7afl3	402	13	delete	delete	VB
cord-342936-43u7afl3	402	14	)	)	-RRB-
cord-342936-43u7afl3	402	15	its	-PRON-	PRP$
cord-342936-43u7afl3	402	16	protective	protective	JJ
cord-342936-43u7afl3	402	17	glycan	glycan	NN
cord-342936-43u7afl3	402	18	shield	shield	NN
cord-342936-43u7afl3	402	19	to	to	TO
cord-342936-43u7afl3	402	20	escape	escape	VB
cord-342936-43u7afl3	402	21	CBA	CBA	NNP
cord-342936-43u7afl3	402	22	pressure	pressure	NN
cord-342936-43u7afl3	402	23	this	this	DT
cord-342936-43u7afl3	402	24	adds	add	VBZ
cord-342936-43u7afl3	402	25	an	an	DT
cord-342936-43u7afl3	402	26	exciting	exciting	JJ
cord-342936-43u7afl3	402	27	new	new	JJ
cord-342936-43u7afl3	402	28	dimension	dimension	NN
cord-342936-43u7afl3	402	29	to	to	IN
cord-342936-43u7afl3	402	30	CBAs	cba	NNS
cord-342936-43u7afl3	402	31	as	as	IN
cord-342936-43u7afl3	402	32	a	a	DT
cord-342936-43u7afl3	402	33	novel	novel	JJ
cord-342936-43u7afl3	402	34	conceptual	conceptual	JJ
cord-342936-43u7afl3	402	35	class	class	NN
cord-342936-43u7afl3	402	36	of	of	IN
cord-342936-43u7afl3	402	37	antimicrobial	antimicrobial	JJ
cord-342936-43u7afl3	402	38	agents	agent	NNS
cord-342936-43u7afl3	402	39	.	.	.
cord-342936-43u7afl3	403	1	They	-PRON-	PRP
cord-342936-43u7afl3	403	2	may	may	MD
cord-342936-43u7afl3	403	3	indeed	indeed	RB
cord-342936-43u7afl3	403	4	represent	represent	VB
cord-342936-43u7afl3	403	5	the	the	DT
cord-342936-43u7afl3	403	6	first	first	JJ
cord-342936-43u7afl3	403	7	agents	agent	NNS
cord-342936-43u7afl3	403	8	that	that	WDT
cord-342936-43u7afl3	403	9	combine	combine	VBP
cord-342936-43u7afl3	403	10	direct	direct	JJ
cord-342936-43u7afl3	403	11	chemotherapeutic	chemotherapeutic	JJ
cord-342936-43u7afl3	403	12	activity	activity	NN
cord-342936-43u7afl3	403	13	and	and	CC
cord-342936-43u7afl3	403	14	an	an	DT
cord-342936-43u7afl3	403	15	indirect	indirect	JJ
cord-342936-43u7afl3	403	16	,	,	,
cord-342936-43u7afl3	403	17	active	active	JJ
cord-342936-43u7afl3	403	18	involvement	involvement	NN
cord-342936-43u7afl3	403	19	of	of	IN
cord-342936-43u7afl3	403	20	the	the	DT
cord-342936-43u7afl3	403	21	immune	immune	JJ
cord-342936-43u7afl3	403	22	system	system	NN
cord-342936-43u7afl3	403	23	by	by	IN
cord-342936-43u7afl3	403	24	triggering	trigger	VBG
cord-342936-43u7afl3	403	25	a	a	DT
cord-342936-43u7afl3	403	26	humoral	humoral	JJ
cord-342936-43u7afl3	403	27	response	response	NN
cord-342936-43u7afl3	403	28	(	(	-LRB-
cord-342936-43u7afl3	403	29	by	by	IN
cord-342936-43u7afl3	403	30	producing	produce	VBG
cord-342936-43u7afl3	403	31	neutralizing	neutralize	VBG
cord-342936-43u7afl3	403	32	antibodies	antibody	NNS
cord-342936-43u7afl3	403	33	)	)	-RRB-
cord-342936-43u7afl3	403	34	and/or	and/or	CC
cord-342936-43u7afl3	403	35	a	a	DT
cord-342936-43u7afl3	403	36	cellular	cellular	JJ
cord-342936-43u7afl3	403	37	response	response	NN
cord-342936-43u7afl3	403	38	(	(	-LRB-
cord-342936-43u7afl3	403	39	T	t	NN
cord-342936-43u7afl3	403	40	-	-	HYPH
cord-342936-43u7afl3	403	41	cell	cell	NN
cord-342936-43u7afl3	403	42	-	-	HYPH
cord-342936-43u7afl3	403	43	based	base	VBN
cord-342936-43u7afl3	403	44	immunity	immunity	NN
cord-342936-43u7afl3	403	45	)	)	-RRB-
cord-342936-43u7afl3	403	46	.	.	.
cord-342936-43u7afl3	404	1	Although	although	IN
cord-342936-43u7afl3	404	2	the	the	DT
cord-342936-43u7afl3	404	3	triggering	triggering	NN
cord-342936-43u7afl3	404	4	of	of	IN
cord-342936-43u7afl3	404	5	a	a	DT
cord-342936-43u7afl3	404	6	cellular	cellular	JJ
cord-342936-43u7afl3	404	7	immune	immune	JJ
cord-342936-43u7afl3	404	8	response	response	NN
cord-342936-43u7afl3	404	9	by	by	IN
cord-342936-43u7afl3	404	10	CBAs	cba	NNS
cord-342936-43u7afl3	404	11	is	be	VBZ
cord-342936-43u7afl3	404	12	still	still	RB
cord-342936-43u7afl3	404	13	to	to	TO
cord-342936-43u7afl3	404	14	be	be	VB
cord-342936-43u7afl3	404	15	confirmed	confirm	VBN
cord-342936-43u7afl3	404	16	in	in	IN
cord-342936-43u7afl3	404	17	vivo	vivo	NN
cord-342936-43u7afl3	404	18	,	,	,
cord-342936-43u7afl3	404	19	indirect	indirect	JJ
cord-342936-43u7afl3	404	20	information	information	NN
cord-342936-43u7afl3	404	21	suggests	suggest	VBZ
cord-342936-43u7afl3	404	22	that	that	IN
cord-342936-43u7afl3	404	23	an	an	DT
cord-342936-43u7afl3	404	24	immune	immune	JJ
cord-342936-43u7afl3	404	25	response	response	NN
cord-342936-43u7afl3	404	26	is	be	VBZ
cord-342936-43u7afl3	404	27	to	to	TO
cord-342936-43u7afl3	404	28	be	be	VB
cord-342936-43u7afl3	404	29	expected	expect	VBN
cord-342936-43u7afl3	404	30	after	after	IN
cord-342936-43u7afl3	404	31	prolonged	prolong	VBN
cord-342936-43u7afl3	404	32	treatment	treatment	NN
cord-342936-43u7afl3	404	33	of	of	IN
cord-342936-43u7afl3	404	34	the	the	DT
cord-342936-43u7afl3	404	35	pathogen	pathogen	NN
cord-342936-43u7afl3	404	36	with	with	IN
cord-342936-43u7afl3	404	37	CBAs	cba	NNS
cord-342936-43u7afl3	404	38	.	.	.
cord-342936-43u7afl3	405	1	Immunology	Immunology	NNP
cord-342936-43u7afl3	405	2	of	of	IN
cord-342936-43u7afl3	405	3	hepatitis	hepatitis	NNP
cord-342936-43u7afl3	405	4	B	B	NNP
cord-342936-43u7afl3	405	5	virus	virus	NN
cord-342936-43u7afl3	405	6	and	and	CC
cord-342936-43u7afl3	405	7	hepatitis	hepatitis	NN
cord-342936-43u7afl3	405	8	C	C	NNP
cord-342936-43u7afl3	405	9	virus	virus	NN
cord-342936-43u7afl3	405	10	infection	infection	NN
cord-342936-43u7afl3	405	11	Progress	Progress	NNP
cord-342936-43u7afl3	405	12	and	and	CC
cord-342936-43u7afl3	405	13	obstacles	obstacle	NNS
cord-342936-43u7afl3	405	14	in	in	IN
cord-342936-43u7afl3	405	15	the	the	DT
cord-342936-43u7afl3	405	16	development	development	NN
cord-342936-43u7afl3	405	17	of	of	IN
cord-342936-43u7afl3	405	18	an	an	DT
cord-342936-43u7afl3	405	19	AIDS	AIDS	NNP
cord-342936-43u7afl3	405	20	vaccine	vaccine	NN
cord-342936-43u7afl3	405	21	Viral	viral	JJ
cord-342936-43u7afl3	405	22	escape	escape	NN
cord-342936-43u7afl3	405	23	by	by	IN
cord-342936-43u7afl3	405	24	selection	selection	NN
cord-342936-43u7afl3	405	25	of	of	IN
cord-342936-43u7afl3	405	26	cytotoxic	cytotoxic	JJ
cord-342936-43u7afl3	405	27	T	t	NN
cord-342936-43u7afl3	405	28	-	-	HYPH
cord-342936-43u7afl3	405	29	cell	cell	NN
cord-342936-43u7afl3	405	30	-	-	HYPH
cord-342936-43u7afl3	405	31	resistant	resistant	JJ
cord-342936-43u7afl3	405	32	variants	variant	NNS
cord-342936-43u7afl3	405	33	in	in	IN
cord-342936-43u7afl3	405	34	influenza	influenza	NN
cord-342936-43u7afl3	405	35	A	a	DT
cord-342936-43u7afl3	405	36	virus	virus	NN
cord-342936-43u7afl3	405	37	pneumonia	pneumonia	NN
cord-342936-43u7afl3	405	38	Antivirals	antiviral	NNS
cord-342936-43u7afl3	405	39	and	and	CC
cord-342936-43u7afl3	405	40	antiviral	antiviral	JJ
cord-342936-43u7afl3	405	41	strategies	strategy	NNS
cord-342936-43u7afl3	406	1	The	the	DT
cord-342936-43u7afl3	406	2	first	first	JJ
cord-342936-43u7afl3	406	3	extensive	extensive	JJ
cord-342936-43u7afl3	406	4	description	description	NN
cord-342936-43u7afl3	406	5	of	of	IN
cord-342936-43u7afl3	406	6	the	the	DT
cord-342936-43u7afl3	406	7	new	new	JJ
cord-342936-43u7afl3	406	8	concept	concept	NN
cord-342936-43u7afl3	406	9	that	that	IN
cord-342936-43u7afl3	406	10	CBAs	cba	NNS
cord-342936-43u7afl3	406	11	may	may	MD
cord-342936-43u7afl3	406	12	have	have	VB
cord-342936-43u7afl3	406	13	a	a	DT
cord-342936-43u7afl3	406	14	dual	dual	JJ
cord-342936-43u7afl3	406	15	mechanism	mechanism	NN
cord-342936-43u7afl3	406	16	of	of	IN
cord-342936-43u7afl3	406	17	antiviral	antiviral	JJ
cord-342936-43u7afl3	406	18	action	action	NN
cord-342936-43u7afl3	406	19	Database	Database	NNP
cord-342936-43u7afl3	406	20	analysis	analysis	NN
cord-342936-43u7afl3	406	21	of	of	IN
cord-342936-43u7afl3	406	22	O	o	NN
cord-342936-43u7afl3	406	23	-	-	HYPH
cord-342936-43u7afl3	406	24	glycosylation	glycosylation	NN
cord-342936-43u7afl3	406	25	sites	site	NNS
cord-342936-43u7afl3	406	26	in	in	IN
cord-342936-43u7afl3	406	27	proteins	protein	NNS
cord-342936-43u7afl3	407	1	Intracellular	Intracellular	NNP
cord-342936-43u7afl3	407	2	functions	function	NNS
cord-342936-43u7afl3	407	3	of	of	IN
cord-342936-43u7afl3	407	4	N	n	CD
cord-342936-43u7afl3	407	5	-	-	HYPH
cord-342936-43u7afl3	407	6	linked	link	VBN
cord-342936-43u7afl3	407	7	glycans	glycan	NNS
cord-342936-43u7afl3	407	8	Glycosylation	Glycosylation	NNP
cord-342936-43u7afl3	407	9	:	:	:
cord-342936-43u7afl3	407	10	heterogeneity	heterogeneity	NN
cord-342936-43u7afl3	407	11	and	and	CC
cord-342936-43u7afl3	407	12	the	the	DT
cord-342936-43u7afl3	407	13	3D	3d	JJ
cord-342936-43u7afl3	407	14	structure	structure	NN
cord-342936-43u7afl3	407	15	of	of	IN
cord-342936-43u7afl3	407	16	proteins	protein	NNS
cord-342936-43u7afl3	407	17	Biological	biological	JJ
cord-342936-43u7afl3	407	18	importance	importance	NN
cord-342936-43u7afl3	407	19	of	of	IN
cord-342936-43u7afl3	407	20	glycosylation	glycosylation	NN
cord-342936-43u7afl3	407	21	Role	role	NN
cord-342936-43u7afl3	407	22	of	of	IN
cord-342936-43u7afl3	407	23	N	n	CD
cord-342936-43u7afl3	407	24	-	-	HYPH
cord-342936-43u7afl3	407	25	oligosaccharide	oligosaccharide	NN
cord-342936-43u7afl3	407	26	endoplasmic	endoplasmic	NN
cord-342936-43u7afl3	407	27	reticulum	reticulum	NN
cord-342936-43u7afl3	407	28	processing	processing	NN
cord-342936-43u7afl3	407	29	reactions	reaction	NNS
cord-342936-43u7afl3	407	30	in	in	IN
cord-342936-43u7afl3	407	31	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	407	32	folding	folding	NN
cord-342936-43u7afl3	407	33	and	and	CC
cord-342936-43u7afl3	407	34	degradation	degradation	NN
cord-342936-43u7afl3	407	35	Hydration	hydration	NN
cord-342936-43u7afl3	407	36	of	of	IN
cord-342936-43u7afl3	407	37	a	a	DT
cord-342936-43u7afl3	407	38	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	407	39	:	:	:
cord-342936-43u7afl3	407	40	relative	relative	JJ
cord-342936-43u7afl3	407	41	water	water	NN
cord-342936-43u7afl3	407	42	affinity	affinity	NN
cord-342936-43u7afl3	407	43	of	of	IN
cord-342936-43u7afl3	407	44	peptide	peptide	NN
cord-342936-43u7afl3	407	45	and	and	CC
cord-342936-43u7afl3	407	46	glycan	glycan	NN
cord-342936-43u7afl3	407	47	moieties	moiety	NNS
cord-342936-43u7afl3	407	48	N	n	NN
cord-342936-43u7afl3	407	49	-	-	HYPH
cord-342936-43u7afl3	407	50	glycan	glycan	NN
cord-342936-43u7afl3	407	51	processing	processing	NN
cord-342936-43u7afl3	407	52	in	in	IN
cord-342936-43u7afl3	407	53	ER	ER	NNP
cord-342936-43u7afl3	407	54	quality	quality	NN
cord-342936-43u7afl3	407	55	control	control	NN
cord-342936-43u7afl3	407	56	Role	role	NN
cord-342936-43u7afl3	407	57	of	of	IN
cord-342936-43u7afl3	407	58	the	the	DT
cord-342936-43u7afl3	407	59	mannose	mannose	NN
cord-342936-43u7afl3	407	60	-	-	HYPH
cord-342936-43u7afl3	407	61	binding	bind	VBG
cord-342936-43u7afl3	407	62	lectin	lectin	NN
cord-342936-43u7afl3	407	63	in	in	IN
cord-342936-43u7afl3	407	64	innate	innate	JJ
cord-342936-43u7afl3	407	65	immunity	immunity	NN
cord-342936-43u7afl3	407	66	Specificity	Specificity	NNP
cord-342936-43u7afl3	407	67	of	of	IN
cord-342936-43u7afl3	407	68	DC	DC	NNP
cord-342936-43u7afl3	407	69	-	-	HYPH
cord-342936-43u7afl3	407	70	SIGN	sign	NN
cord-342936-43u7afl3	407	71	for	for	IN
cord-342936-43u7afl3	407	72	mannose	mannose	NN
cord-342936-43u7afl3	407	73	-	-	HYPH
cord-342936-43u7afl3	407	74	and	and	CC
cord-342936-43u7afl3	407	75	fucose	fucose	NN
cord-342936-43u7afl3	407	76	-	-	HYPH
cord-342936-43u7afl3	407	77	containing	contain	VBG
cord-342936-43u7afl3	407	78	glycans	glycan	NNS
cord-342936-43u7afl3	407	79	Defensins	Defensins	NNP
cord-342936-43u7afl3	407	80	:	:	:
cord-342936-43u7afl3	407	81	natural	natural	JJ
cord-342936-43u7afl3	407	82	anti	anti	JJ
cord-342936-43u7afl3	407	83	-	-	JJ
cord-342936-43u7afl3	407	84	HIV	HIV	NNP
cord-342936-43u7afl3	407	85	peptides	peptide	NNS
cord-342936-43u7afl3	407	86	Carbohydrate	Carbohydrate	NNP
cord-342936-43u7afl3	407	87	recognition	recognition	NN
cord-342936-43u7afl3	407	88	systems	system	NNS
cord-342936-43u7afl3	407	89	in	in	IN
cord-342936-43u7afl3	407	90	autoimmunity	autoimmunity	NN
cord-342936-43u7afl3	407	91	Adhesion	adhesion	NN
cord-342936-43u7afl3	407	92	molecules	molecule	NNS
cord-342936-43u7afl3	407	93	in	in	IN
cord-342936-43u7afl3	407	94	leukocyte	leukocyte	NN
cord-342936-43u7afl3	407	95	endothelial	endothelial	JJ
cord-342936-43u7afl3	407	96	interaction	interaction	NN
cord-342936-43u7afl3	407	97	Discovery	Discovery	NNP
cord-342936-43u7afl3	407	98	of	of	IN
cord-342936-43u7afl3	407	99	cyanovirin	cyanovirin	NNP
cord-342936-43u7afl3	407	100	-	-	HYPH
cord-342936-43u7afl3	407	101	N	N	NNP
cord-342936-43u7afl3	407	102	,	,	,
cord-342936-43u7afl3	407	103	a	a	DT
cord-342936-43u7afl3	407	104	novel	novel	JJ
cord-342936-43u7afl3	407	105	human	human	JJ
cord-342936-43u7afl3	407	106	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	407	107	virus	virus	NN
cord-342936-43u7afl3	407	108	-	-	HYPH
cord-342936-43u7afl3	407	109	inactivating	inactivate	VBG
cord-342936-43u7afl3	407	110	protein	protein	NN
cord-342936-43u7afl3	407	111	that	that	WDT
cord-342936-43u7afl3	407	112	binds	bind	VBZ
cord-342936-43u7afl3	407	113	viral	viral	JJ
cord-342936-43u7afl3	407	114	surface	surface	NN
cord-342936-43u7afl3	407	115	envelope	envelope	NN
cord-342936-43u7afl3	407	116	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	407	117	gp120	gp120	NN
cord-342936-43u7afl3	407	118	:	:	:
cord-342936-43u7afl3	407	119	potential	potential	JJ
cord-342936-43u7afl3	407	120	applications	application	NNS
cord-342936-43u7afl3	407	121	to	to	IN
cord-342936-43u7afl3	407	122	microbicide	microbicide	VB
cord-342936-43u7afl3	407	123	development	development	NN
cord-342936-43u7afl3	407	124	Solution	Solution	NNP
cord-342936-43u7afl3	407	125	structure	structure	NN
cord-342936-43u7afl3	407	126	of	of	IN
cord-342936-43u7afl3	407	127	cyanovirin	cyanovirin	NNP
cord-342936-43u7afl3	407	128	-	-	HYPH
cord-342936-43u7afl3	407	129	N	N	NNP
cord-342936-43u7afl3	407	130	,	,	,
cord-342936-43u7afl3	407	131	a	a	DT
cord-342936-43u7afl3	407	132	potent	potent	JJ
cord-342936-43u7afl3	407	133	HIV	HIV	NNP
cord-342936-43u7afl3	407	134	-	-	HYPH
cord-342936-43u7afl3	407	135	inactivating	inactivate	VBG
cord-342936-43u7afl3	407	136	protein	protein	NN
cord-342936-43u7afl3	407	137	Crystal	Crystal	NNP
cord-342936-43u7afl3	407	138	structure	structure	NN
cord-342936-43u7afl3	407	139	of	of	IN
cord-342936-43u7afl3	407	140	cyanovirin	cyanovirin	NNP
cord-342936-43u7afl3	407	141	-	-	HYPH
cord-342936-43u7afl3	407	142	N	N	NNP
cord-342936-43u7afl3	407	143	,	,	,
cord-342936-43u7afl3	407	144	a	a	DT
cord-342936-43u7afl3	407	145	potent	potent	JJ
cord-342936-43u7afl3	407	146	HIV	HIV	NNP
cord-342936-43u7afl3	407	147	-	-	HYPH
cord-342936-43u7afl3	407	148	inactivating	inactivate	VBG
cord-342936-43u7afl3	407	149	protein	protein	NN
cord-342936-43u7afl3	407	150	,	,	,
cord-342936-43u7afl3	407	151	shows	show	VBZ
cord-342936-43u7afl3	407	152	unexpected	unexpected	JJ
cord-342936-43u7afl3	407	153	domain	domain	NN
cord-342936-43u7afl3	407	154	swapping	swap	VBG
cord-342936-43u7afl3	407	155	Structures	structure	NNS
cord-342936-43u7afl3	407	156	of	of	IN
cord-342936-43u7afl3	407	157	the	the	DT
cord-342936-43u7afl3	407	158	complexes	complex	NNS
cord-342936-43u7afl3	407	159	of	of	IN
cord-342936-43u7afl3	407	160	a	a	DT
cord-342936-43u7afl3	407	161	potent	potent	JJ
cord-342936-43u7afl3	407	162	anti	anti	JJ
cord-342936-43u7afl3	407	163	-	-	JJ
cord-342936-43u7afl3	407	164	HIV	hiv	JJ
cord-342936-43u7afl3	407	165	protein	protein	NN
cord-342936-43u7afl3	407	166	cyanovirin	cyanovirin	NNP
cord-342936-43u7afl3	407	167	-	-	HYPH
cord-342936-43u7afl3	407	168	N	n	NN
cord-342936-43u7afl3	407	169	and	and	CC
cord-342936-43u7afl3	407	170	high	high	JJ
cord-342936-43u7afl3	407	171	mannose	mannose	NN
cord-342936-43u7afl3	407	172	oligosaccharides	oligosaccharide	NNS
cord-342936-43u7afl3	407	173	Solution	Solution	NNP
cord-342936-43u7afl3	407	174	structure	structure	NN
cord-342936-43u7afl3	407	175	of	of	IN
cord-342936-43u7afl3	407	176	a	a	DT
cord-342936-43u7afl3	407	177	cyanovirin	cyanovirin	NNP
cord-342936-43u7afl3	407	178	-	-	HYPH
cord-342936-43u7afl3	407	179	N	n	NN
cord-342936-43u7afl3	407	180	:	:	:
cord-342936-43u7afl3	407	181	Man	man	NN
cord-342936-43u7afl3	407	182	α1	α1	NN
cord-342936-43u7afl3	407	183	-	-	:
cord-342936-43u7afl3	407	184	2Manα	2Manα	NNP
cord-342936-43u7afl3	407	185	complex	complex	JJ
cord-342936-43u7afl3	407	186	:	:	:
cord-342936-43u7afl3	407	187	structural	structural	JJ
cord-342936-43u7afl3	407	188	basis	basis	NN
cord-342936-43u7afl3	407	189	for	for	IN
cord-342936-43u7afl3	407	190	high	high	JJ
cord-342936-43u7afl3	407	191	-	-	HYPH
cord-342936-43u7afl3	407	192	affinity	affinity	NN
cord-342936-43u7afl3	407	193	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	407	194	-	-	HYPH
cord-342936-43u7afl3	407	195	mediated	mediate	VBN
cord-342936-43u7afl3	407	196	binding	binding	NN
cord-342936-43u7afl3	407	197	to	to	IN
cord-342936-43u7afl3	407	198	gp120	gp120	NNP
cord-342936-43u7afl3	407	199	Cyanovirin	Cyanovirin	NNP
cord-342936-43u7afl3	407	200	-	-	HYPH
cord-342936-43u7afl3	407	201	N	N	NNP
cord-342936-43u7afl3	407	202	defines	define	VBZ
cord-342936-43u7afl3	407	203	a	a	DT
cord-342936-43u7afl3	407	204	new	new	JJ
cord-342936-43u7afl3	407	205	class	class	NN
cord-342936-43u7afl3	407	206	of	of	IN
cord-342936-43u7afl3	407	207	antiviral	antiviral	JJ
cord-342936-43u7afl3	407	208	agent	agent	NN
cord-342936-43u7afl3	407	209	targeting	target	VBG
cord-342936-43u7afl3	407	210	N	N	NNP
cord-342936-43u7afl3	407	211	-	-	HYPH
cord-342936-43u7afl3	407	212	linked	link	VBN
cord-342936-43u7afl3	407	213	,	,	,
cord-342936-43u7afl3	407	214	highmannose	highmannose	JJ
cord-342936-43u7afl3	407	215	glycans	glycan	NNS
cord-342936-43u7afl3	407	216	in	in	IN
cord-342936-43u7afl3	407	217	an	an	DT
cord-342936-43u7afl3	407	218	oligosaccharide	oligosaccharide	NN
cord-342936-43u7afl3	407	219	-	-	HYPH
cord-342936-43u7afl3	407	220	specific	specific	JJ
cord-342936-43u7afl3	407	221	manner	manner	NN
cord-342936-43u7afl3	407	222	Isolation	isolation	NN
cord-342936-43u7afl3	407	223	and	and	CC
cord-342936-43u7afl3	407	224	characterization	characterization	NN
cord-342936-43u7afl3	407	225	of	of	IN
cord-342936-43u7afl3	407	226	a	a	DT
cord-342936-43u7afl3	407	227	mannan	mannan	NN
cord-342936-43u7afl3	407	228	-	-	HYPH
cord-342936-43u7afl3	407	229	binding	bind	VBG
cord-342936-43u7afl3	407	230	lectin	lectin	NN
cord-342936-43u7afl3	407	231	from	from	IN
cord-342936-43u7afl3	407	232	the	the	DT
cord-342936-43u7afl3	407	233	freshwater	freshwater	JJ
cord-342936-43u7afl3	407	234	Cyanobacterium	Cyanobacterium	NNP
cord-342936-43u7afl3	407	235	(	(	-LRB-
cord-342936-43u7afl3	407	236	blue	blue	JJ
cord-342936-43u7afl3	407	237	-	-	HYPH
cord-342936-43u7afl3	407	238	green	green	JJ
cord-342936-43u7afl3	407	239	algae	algae	NN
cord-342936-43u7afl3	407	240	)	)	-RRB-
cord-342936-43u7afl3	408	1	Microcystis	Microcystis	NNP
cord-342936-43u7afl3	408	2	viridis	viridis	NN
cord-342936-43u7afl3	408	3	Crystal	Crystal	NNP
cord-342936-43u7afl3	408	4	structures	structure	NNS
cord-342936-43u7afl3	408	5	of	of	IN
cord-342936-43u7afl3	408	6	the	the	DT
cord-342936-43u7afl3	408	7	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	408	8	inhibitory	inhibitory	JJ
cord-342936-43u7afl3	408	9	cyanobacterial	cyanobacterial	JJ
cord-342936-43u7afl3	408	10	protein	protein	NN
cord-342936-43u7afl3	408	11	MVL	MVL	NNP
cord-342936-43u7afl3	408	12	free	free	JJ
cord-342936-43u7afl3	408	13	and	and	CC
cord-342936-43u7afl3	408	14	bound	bind	VBN
cord-342936-43u7afl3	408	15	to	to	IN
cord-342936-43u7afl3	408	16	Man	man	NN
cord-342936-43u7afl3	408	17	3	3	CD
cord-342936-43u7afl3	408	18	GlcNAc	glcnac	NN
cord-342936-43u7afl3	408	19	2	2	CD
cord-342936-43u7afl3	409	1	:	:	:
cord-342936-43u7afl3	409	2	structural	structural	JJ
cord-342936-43u7afl3	409	3	basis	basis	NN
cord-342936-43u7afl3	409	4	for	for	IN
cord-342936-43u7afl3	409	5	specificity	specificity	NN
cord-342936-43u7afl3	409	6	and	and	CC
cord-342936-43u7afl3	409	7	highaffinity	highaffinity	NN
cord-342936-43u7afl3	409	8	binding	bind	VBG
cord-342936-43u7afl3	409	9	to	to	IN
cord-342936-43u7afl3	409	10	the	the	DT
cord-342936-43u7afl3	409	11	core	core	NN
cord-342936-43u7afl3	409	12	pentasaccharide	pentasaccharide	NN
cord-342936-43u7afl3	409	13	from	from	IN
cord-342936-43u7afl3	409	14	N	n	NN
cord-342936-43u7afl3	409	15	-	-	HYPH
cord-342936-43u7afl3	409	16	linked	link	VBN
cord-342936-43u7afl3	409	17	oligomannoside	oligomannoside	RB
cord-342936-43u7afl3	410	1	A	a	DT
cord-342936-43u7afl3	410	2	potent	potent	JJ
cord-342936-43u7afl3	410	3	novel	novel	JJ
cord-342936-43u7afl3	410	4	anti	anti	JJ
cord-342936-43u7afl3	410	5	-	-	JJ
cord-342936-43u7afl3	410	6	HIV	hiv	JJ
cord-342936-43u7afl3	410	7	protein	protein	NN
cord-342936-43u7afl3	410	8	from	from	IN
cord-342936-43u7afl3	410	9	the	the	DT
cord-342936-43u7afl3	410	10	cultured	cultured	JJ
cord-342936-43u7afl3	410	11	cyanobacterium	cyanobacterium	NN
cord-342936-43u7afl3	410	12	Scytonema	Scytonema	NNP
cord-342936-43u7afl3	410	13	varium	varium	NN
cord-342936-43u7afl3	410	14	Oligosaccharide	Oligosaccharide	NNP
cord-342936-43u7afl3	410	15	and	and	CC
cord-342936-43u7afl3	410	16	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	410	17	microassays	microassay	VBZ
cord-342936-43u7afl3	410	18	as	as	IN
cord-342936-43u7afl3	410	19	tools	tool	NNS
cord-342936-43u7afl3	410	20	in	in	IN
cord-342936-43u7afl3	410	21	HIV	HIV	NNP
cord-342936-43u7afl3	410	22	glycobiology	glycobiology	NN
cord-342936-43u7afl3	410	23	:	:	:
cord-342936-43u7afl3	411	1	glycandependent	glycandependent	NNP
cord-342936-43u7afl3	411	2	gp120	gp120	NNP
cord-342936-43u7afl3	411	3	/	/	SYM
cord-342936-43u7afl3	411	4	protein	protein	NN
cord-342936-43u7afl3	411	5	interactions	interaction	NNS
cord-342936-43u7afl3	412	1	Structural	structural	JJ
cord-342936-43u7afl3	412	2	studies	study	NNS
cord-342936-43u7afl3	412	3	of	of	IN
cord-342936-43u7afl3	412	4	algal	algal	JJ
cord-342936-43u7afl3	412	5	lectins	lectin	NNS
cord-342936-43u7afl3	412	6	with	with	IN
cord-342936-43u7afl3	412	7	anti	anti	JJ
cord-342936-43u7afl3	412	8	-	-	JJ
cord-342936-43u7afl3	412	9	HIV	hiv	JJ
cord-342936-43u7afl3	412	10	activity	activity	NN
cord-342936-43u7afl3	412	11	A	a	DT
cord-342936-43u7afl3	412	12	D	d	NN
cord-342936-43u7afl3	412	13	-	-	HYPH
cord-342936-43u7afl3	412	14	mannose	mannose	NN
cord-342936-43u7afl3	412	15	-	-	HYPH
cord-342936-43u7afl3	412	16	specific	specific	JJ
cord-342936-43u7afl3	412	17	lectin	lectin	NN
cord-342936-43u7afl3	412	18	from	from	IN
cord-342936-43u7afl3	412	19	Gerardia	Gerardia	NNP
cord-342936-43u7afl3	412	20	savaglia	savaglia	NN
cord-342936-43u7afl3	412	21	that	that	WDT
cord-342936-43u7afl3	412	22	inhibits	inhibit	VBZ
cord-342936-43u7afl3	412	23	nucleocytoplasmic	nucleocytoplasmic	JJ
cord-342936-43u7afl3	412	24	transport	transport	NN
cord-342936-43u7afl3	412	25	of	of	IN
cord-342936-43u7afl3	412	26	mRNA	mRNA	NNP
cord-342936-43u7afl3	412	27	Molecular	Molecular	NNP
cord-342936-43u7afl3	412	28	cloning	cloning	NN
cord-342936-43u7afl3	412	29	of	of	IN
cord-342936-43u7afl3	412	30	actinohivin	actinohivin	NNP
cord-342936-43u7afl3	412	31	,	,	,
cord-342936-43u7afl3	412	32	a	a	DT
cord-342936-43u7afl3	412	33	novel	novel	JJ
cord-342936-43u7afl3	412	34	anti	anti	JJ
cord-342936-43u7afl3	412	35	-	-	JJ
cord-342936-43u7afl3	412	36	HIV	hiv	JJ
cord-342936-43u7afl3	412	37	protein	protein	NN
cord-342936-43u7afl3	412	38	from	from	IN
cord-342936-43u7afl3	412	39	an	an	DT
cord-342936-43u7afl3	412	40	actinomycete	actinomycete	NN
cord-342936-43u7afl3	412	41	,	,	,
cord-342936-43u7afl3	412	42	and	and	CC
cord-342936-43u7afl3	412	43	its	-PRON-	PRP$
cord-342936-43u7afl3	412	44	expression	expression	NN
cord-342936-43u7afl3	412	45	in	in	IN
cord-342936-43u7afl3	412	46	Escherichia	Escherichia	NNP
cord-342936-43u7afl3	412	47	coli	coli	VBZ
cord-342936-43u7afl3	412	48	Isolation	isolation	NN
cord-342936-43u7afl3	412	49	and	and	CC
cord-342936-43u7afl3	412	50	characterization	characterization	NN
cord-342936-43u7afl3	412	51	of	of	IN
cord-342936-43u7afl3	412	52	griffithsin	griffithsin	NNP
cord-342936-43u7afl3	412	53	,	,	,
cord-342936-43u7afl3	412	54	a	a	DT
cord-342936-43u7afl3	412	55	novel	novel	JJ
cord-342936-43u7afl3	412	56	HIV	HIV	NNP
cord-342936-43u7afl3	412	57	-	-	HYPH
cord-342936-43u7afl3	412	58	inactivating	inactivate	VBG
cord-342936-43u7afl3	412	59	protein	protein	NN
cord-342936-43u7afl3	412	60	,	,	,
cord-342936-43u7afl3	412	61	from	from	IN
cord-342936-43u7afl3	412	62	the	the	DT
cord-342936-43u7afl3	412	63	red	red	JJ
cord-342936-43u7afl3	412	64	alga	alga	NN
cord-342936-43u7afl3	412	65	Griffithsia	Griffithsia	NNP
cord-342936-43u7afl3	412	66	spp	spp	NNP
cord-342936-43u7afl3	413	1	The	the	DT
cord-342936-43u7afl3	413	2	D	d	NN
cord-342936-43u7afl3	413	3	-	-	HYPH
cord-342936-43u7afl3	413	4	mannose	mannose	NN
cord-342936-43u7afl3	413	5	-	-	HYPH
cord-342936-43u7afl3	413	6	specific	specific	JJ
cord-342936-43u7afl3	413	7	lectin	lectin	NN
cord-342936-43u7afl3	413	8	from	from	IN
cord-342936-43u7afl3	413	9	Gerardia	Gerardia	NNP
cord-342936-43u7afl3	413	10	savaglia	savaglia	NN
cord-342936-43u7afl3	413	11	blocks	block	NNS
cord-342936-43u7afl3	413	12	binding	bind	VBG
cord-342936-43u7afl3	413	13	of	of	IN
cord-342936-43u7afl3	413	14	human	human	JJ
cord-342936-43u7afl3	413	15	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	413	16	virus	virus	NN
cord-342936-43u7afl3	413	17	type	type	NN
cord-342936-43u7afl3	413	18	1	1	CD
cord-342936-43u7afl3	413	19	to	to	IN
cord-342936-43u7afl3	413	20	H9	h9	NN
cord-342936-43u7afl3	413	21	cells	cell	NNS
cord-342936-43u7afl3	413	22	and	and	CC
cord-342936-43u7afl3	413	23	human	human	JJ
cord-342936-43u7afl3	413	24	lymphocytes	lymphocyte	NNS
cord-342936-43u7afl3	413	25	in	in	IN
cord-342936-43u7afl3	413	26	vitro	vitro	FW
cord-342936-43u7afl3	413	27	Actinohivin	Actinohivin	NNP
cord-342936-43u7afl3	413	28	,	,	,
cord-342936-43u7afl3	413	29	a	a	DT
cord-342936-43u7afl3	413	30	novel	novel	JJ
cord-342936-43u7afl3	413	31	anti	anti	JJ
cord-342936-43u7afl3	413	32	-	-	JJ
cord-342936-43u7afl3	413	33	HIV	hiv	JJ
cord-342936-43u7afl3	413	34	protein	protein	NN
cord-342936-43u7afl3	413	35	from	from	IN
cord-342936-43u7afl3	413	36	an	an	DT
cord-342936-43u7afl3	413	37	actinomycete	actinomycete	NN
cord-342936-43u7afl3	413	38	that	that	WDT
cord-342936-43u7afl3	413	39	inhibits	inhibit	VBZ
cord-342936-43u7afl3	413	40	syncytium	syncytium	NN
cord-342936-43u7afl3	413	41	formation	formation	NN
cord-342936-43u7afl3	413	42	:	:	:
cord-342936-43u7afl3	413	43	isolation	isolation	NN
cord-342936-43u7afl3	413	44	,	,	,
cord-342936-43u7afl3	413	45	characterization	characterization	NN
cord-342936-43u7afl3	413	46	,	,	,
cord-342936-43u7afl3	413	47	and	and	CC
cord-342936-43u7afl3	413	48	biological	biological	JJ
cord-342936-43u7afl3	413	49	activities	activity	NNS
cord-342936-43u7afl3	413	50	Handbook	Handbook	NNP
cord-342936-43u7afl3	413	51	of	of	IN
cord-342936-43u7afl3	413	52	Plant	Plant	NNP
cord-342936-43u7afl3	413	53	Lectins	Lectins	NNP
cord-342936-43u7afl3	413	54	:	:	:
cord-342936-43u7afl3	413	55	Properties	property	NNS
cord-342936-43u7afl3	413	56	and	and	CC
cord-342936-43u7afl3	413	57	Biomedical	Biomedical	NNP
cord-342936-43u7afl3	413	58	Applications	Applications	NNPS
cord-342936-43u7afl3	413	59	Lectins	Lectins	NNP
cord-342936-43u7afl3	413	60	2nd	2nd	JJ
cord-342936-43u7afl3	413	61	edn	edn	NN
cord-342936-43u7afl3	414	1	The	the	DT
cord-342936-43u7afl3	414	2	mannose	mannose	NN
cord-342936-43u7afl3	414	3	-	-	HYPH
cord-342936-43u7afl3	414	4	specific	specific	JJ
cord-342936-43u7afl3	414	5	bulb	bulb	NN
cord-342936-43u7afl3	414	6	lectin	lectin	NN
cord-342936-43u7afl3	414	7	from	from	IN
cord-342936-43u7afl3	414	8	Galanthus	Galanthus	NNP
cord-342936-43u7afl3	414	9	nivalis	nivalis	NN
cord-342936-43u7afl3	414	10	(	(	-LRB-
cord-342936-43u7afl3	414	11	snowdrop	snowdrop	NN
cord-342936-43u7afl3	414	12	)	)	-RRB-
cord-342936-43u7afl3	414	13	binds	bind	VBZ
cord-342936-43u7afl3	414	14	monoand	monoand	NNP
cord-342936-43u7afl3	414	15	dimannosides	dimannoside	NNS
cord-342936-43u7afl3	414	16	at	at	IN
cord-342936-43u7afl3	414	17	distinct	distinct	JJ
cord-342936-43u7afl3	414	18	sites	site	NNS
cord-342936-43u7afl3	414	19	.	.	.
cord-342936-43u7afl3	415	1	Structure	structure	NN
cord-342936-43u7afl3	415	2	analysis	analysis	NN
cord-342936-43u7afl3	415	3	of	of	IN
cord-342936-43u7afl3	415	4	refined	refined	JJ
cord-342936-43u7afl3	415	5	complexes	complex	NNS
cord-342936-43u7afl3	415	6	at	at	IN
cord-342936-43u7afl3	415	7	2.3	2.3	CD
cord-342936-43u7afl3	415	8	Å	å	NN
cord-342936-43u7afl3	415	9	and	and	CC
cord-342936-43u7afl3	415	10	3.0	3.0	CD
cord-342936-43u7afl3	415	11	Å	å	NN
cord-342936-43u7afl3	415	12	resolution	resolution	NN
cord-342936-43u7afl3	415	13	Crystal	Crystal	NNP
cord-342936-43u7afl3	415	14	structures	structure	NNS
cord-342936-43u7afl3	415	15	of	of	IN
cord-342936-43u7afl3	415	16	Urtica	Urtica	NNP
cord-342936-43u7afl3	415	17	dioica	dioica	NNP
cord-342936-43u7afl3	415	18	agglutinin	agglutinin	NNS
cord-342936-43u7afl3	415	19	and	and	CC
cord-342936-43u7afl3	415	20	its	-PRON-	PRP$
cord-342936-43u7afl3	415	21	complex	complex	NN
cord-342936-43u7afl3	415	22	with	with	IN
cord-342936-43u7afl3	415	23	triacetylchitotriose	triacetylchitotriose	NNP
cord-342936-43u7afl3	415	24	-3)-and	-3)-and	IN
cord-342936-43u7afl3	415	25	α-(1	α-(1	NNP
cord-342936-43u7afl3	415	26	-	-	HYPH
cord-342936-43u7afl3	415	27	6)-D	6)-D	NNP
cord-342936-43u7afl3	415	28	-	-	HYPH
cord-342936-43u7afl3	415	29	mannosespecific	mannosespecific	JJ
cord-342936-43u7afl3	415	30	plant	plant	NN
cord-342936-43u7afl3	415	31	lectins	lectin	NNS
cord-342936-43u7afl3	415	32	are	be	VBP
cord-342936-43u7afl3	415	33	markedly	markedly	RB
cord-342936-43u7afl3	415	34	inhibitory	inhibitory	JJ
cord-342936-43u7afl3	415	35	to	to	IN
cord-342936-43u7afl3	415	36	human	human	JJ
cord-342936-43u7afl3	415	37	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	415	38	virus	virus	NN
cord-342936-43u7afl3	415	39	and	and	CC
cord-342936-43u7afl3	415	40	cytomegalovirus	cytomegalovirus	JJ
cord-342936-43u7afl3	415	41	infections	infection	NNS
cord-342936-43u7afl3	415	42	in	in	IN
cord-342936-43u7afl3	415	43	vitro	vitro	FW
cord-342936-43u7afl3	416	1	The	the	DT
cord-342936-43u7afl3	416	2	mannose	mannose	NN
cord-342936-43u7afl3	416	3	-	-	HYPH
cord-342936-43u7afl3	416	4	specific	specific	JJ
cord-342936-43u7afl3	416	5	plant	plant	NN
cord-342936-43u7afl3	416	6	lectins	lectin	NNS
cord-342936-43u7afl3	416	7	from	from	IN
cord-342936-43u7afl3	416	8	Cymbidium	Cymbidium	NNP
cord-342936-43u7afl3	416	9	hybrid	hybrid	NN
cord-342936-43u7afl3	416	10	and	and	CC
cord-342936-43u7afl3	416	11	Epi	Epi	NNP
cord-342936-43u7afl3	416	12	pactis	pactis	NNP
cord-342936-43u7afl3	416	13	helleborine	helleborine	NNP
cord-342936-43u7afl3	416	14	and	and	CC
cord-342936-43u7afl3	416	15	the	the	DT
cord-342936-43u7afl3	416	16	(	(	-LRB-
cord-342936-43u7afl3	416	17	N	N	NNP
cord-342936-43u7afl3	416	18	-	-	HYPH
cord-342936-43u7afl3	416	19	acetylglucosamine	acetylglucosamine	NNP
cord-342936-43u7afl3	416	20	)	)	-RRB-
cord-342936-43u7afl3	416	21	n	n	JJ
cord-342936-43u7afl3	416	22	-specific	-specific	JJ
cord-342936-43u7afl3	416	23	plant	plant	NN
cord-342936-43u7afl3	416	24	lectin	lectin	NN
cord-342936-43u7afl3	416	25	from	from	IN
cord-342936-43u7afl3	416	26	Urtica	Urtica	NNP
cord-342936-43u7afl3	416	27	dioica	dioica	NN
cord-342936-43u7afl3	416	28	are	be	VBP
cord-342936-43u7afl3	416	29	potent	potent	JJ
cord-342936-43u7afl3	416	30	and	and	CC
cord-342936-43u7afl3	416	31	selective	selective	JJ
cord-342936-43u7afl3	416	32	inhibitors	inhibitor	NNS
cord-342936-43u7afl3	416	33	of	of	IN
cord-342936-43u7afl3	416	34	human	human	JJ
cord-342936-43u7afl3	416	35	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	416	36	virus	virus	NN
cord-342936-43u7afl3	416	37	and	and	CC
cord-342936-43u7afl3	416	38	cytomegalovirus	cytomegalovirus	NN
cord-342936-43u7afl3	416	39	replication	replication	NN
cord-342936-43u7afl3	417	1	in	in	IN
cord-342936-43u7afl3	417	2	vitro	vitro	FW
cord-342936-43u7afl3	417	3	Mannose	mannose	NN
cord-342936-43u7afl3	417	4	-	-	HYPH
cord-342936-43u7afl3	417	5	specific	specific	JJ
cord-342936-43u7afl3	417	6	plant	plant	NN
cord-342936-43u7afl3	417	7	lectins	lectin	NNS
cord-342936-43u7afl3	417	8	from	from	IN
cord-342936-43u7afl3	417	9	the	the	DT
cord-342936-43u7afl3	417	10	Amaryllidaceae	Amaryllidaceae	NNP
cord-342936-43u7afl3	417	11	family	family	NN
cord-342936-43u7afl3	417	12	qualify	qualify	VB
cord-342936-43u7afl3	417	13	as	as	IN
cord-342936-43u7afl3	417	14	efficient	efficient	JJ
cord-342936-43u7afl3	417	15	microbicides	microbicide	NNS
cord-342936-43u7afl3	417	16	for	for	IN
cord-342936-43u7afl3	417	17	prevention	prevention	NN
cord-342936-43u7afl3	417	18	of	of	IN
cord-342936-43u7afl3	417	19	human	human	JJ
cord-342936-43u7afl3	417	20	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	417	21	virus	virus	NN
cord-342936-43u7afl3	417	22	infection	infection	NN
cord-342936-43u7afl3	417	23	Carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	417	24	-	-	HYPH
cord-342936-43u7afl3	417	25	binding	bind	VBG
cord-342936-43u7afl3	417	26	agents	agent	NNS
cord-342936-43u7afl3	418	1	cause	cause	VB
cord-342936-43u7afl3	418	2	deletions	deletion	NNS
cord-342936-43u7afl3	418	3	of	of	IN
cord-342936-43u7afl3	418	4	highly	highly	RB
cord-342936-43u7afl3	418	5	conserved	conserve	VBN
cord-342936-43u7afl3	418	6	glycosylation	glycosylation	NN
cord-342936-43u7afl3	418	7	sites	site	NNS
cord-342936-43u7afl3	418	8	in	in	IN
cord-342936-43u7afl3	418	9	HIV	HIV	NNP
cord-342936-43u7afl3	418	10	gp120	gp120	NNP
cord-342936-43u7afl3	418	11	.	.	.
cord-342936-43u7afl3	419	1	A	a	DT
cord-342936-43u7afl3	419	2	new	new	JJ
cord-342936-43u7afl3	419	3	therapeutic	therapeutic	JJ
cord-342936-43u7afl3	419	4	concept	concept	NN
cord-342936-43u7afl3	419	5	to	to	TO
cord-342936-43u7afl3	419	6	hit	hit	VB
cord-342936-43u7afl3	419	7	the	the	DT
cord-342936-43u7afl3	419	8	Achilles	Achilles	NNP
cord-342936-43u7afl3	419	9	heel	heel	NN
cord-342936-43u7afl3	419	10	of	of	IN
cord-342936-43u7afl3	419	11	HIV	HIV	NNP
cord-342936-43u7afl3	419	12	A	A	NNP
cord-342936-43u7afl3	419	13	β	β	NN
cord-342936-43u7afl3	419	14	-	-	HYPH
cord-342936-43u7afl3	419	15	galactose	galactose	NN
cord-342936-43u7afl3	419	16	-	-	HYPH
cord-342936-43u7afl3	419	17	specific	specific	JJ
cord-342936-43u7afl3	419	18	lectin	lectin	NN
cord-342936-43u7afl3	419	19	isolated	isolate	VBN
cord-342936-43u7afl3	419	20	from	from	IN
cord-342936-43u7afl3	419	21	the	the	DT
cord-342936-43u7afl3	419	22	marine	marine	JJ
cord-342936-43u7afl3	419	23	worm	worm	NN
cord-342936-43u7afl3	419	24	Chaetopterus	Chaetopterus	NNP
cord-342936-43u7afl3	419	25	variopedatus	variopedatus	NNP
cord-342936-43u7afl3	419	26	possesses	possess	VBZ
cord-342936-43u7afl3	419	27	anti	anti	JJ
cord-342936-43u7afl3	419	28	-	-	JJ
cord-342936-43u7afl3	419	29	HIV-1	hiv-1	JJ
cord-342936-43u7afl3	419	30	activity	activity	NN
cord-342936-43u7afl3	420	1	A	a	DT
cord-342936-43u7afl3	420	2	new	new	JJ
cord-342936-43u7afl3	420	3	C	c	NN
cord-342936-43u7afl3	420	4	-	-	HYPH
cord-342936-43u7afl3	420	5	type	type	NN
cord-342936-43u7afl3	420	6	lectin	lectin	NN
cord-342936-43u7afl3	420	7	similar	similar	JJ
cord-342936-43u7afl3	420	8	to	to	IN
cord-342936-43u7afl3	420	9	the	the	DT
cord-342936-43u7afl3	420	10	human	human	JJ
cord-342936-43u7afl3	420	11	immunoreceptor	immunoreceptor	NN
cord-342936-43u7afl3	420	12	DC	DC	NNP
cord-342936-43u7afl3	420	13	-	-	HYPH
cord-342936-43u7afl3	420	14	SIGN	SIGN	NNP
cord-342936-43u7afl3	420	15	mediates	mediate	VBZ
cord-342936-43u7afl3	420	16	symbiont	symbiont	NN
cord-342936-43u7afl3	420	17	acquisition	acquisition	NN
cord-342936-43u7afl3	420	18	by	by	IN
cord-342936-43u7afl3	420	19	a	a	DT
cord-342936-43u7afl3	420	20	marine	marine	JJ
cord-342936-43u7afl3	420	21	nematode	nematode	NN
cord-342936-43u7afl3	420	22	Mannose	mannose	NN
cord-342936-43u7afl3	420	23	-	-	HYPH
cord-342936-43u7afl3	420	24	binding	bind	VBG
cord-342936-43u7afl3	420	25	lectin	lectin	NN
cord-342936-43u7afl3	420	26	(	(	-LRB-
cord-342936-43u7afl3	420	27	MBL	MBL	NNP
cord-342936-43u7afl3	420	28	)	)	-RRB-
cord-342936-43u7afl3	420	29	and	and	CC
cord-342936-43u7afl3	420	30	HIV	HIV	NNP
cord-342936-43u7afl3	420	31	Mannose	Mannose	NNP
cord-342936-43u7afl3	420	32	-	-	HYPH
cord-342936-43u7afl3	420	33	binding	bind	VBG
cord-342936-43u7afl3	420	34	lectin	lectin	NN
cord-342936-43u7afl3	420	35	:	:	:
cord-342936-43u7afl3	420	36	do	do	VBP
cord-342936-43u7afl3	420	37	we	-PRON-	PRP
cord-342936-43u7afl3	420	38	need	need	VB
cord-342936-43u7afl3	420	39	it	-PRON-	PRP
cord-342936-43u7afl3	420	40	?	?	.
cord-342936-43u7afl3	421	1	Identification	identification	NN
cord-342936-43u7afl3	421	2	of	of	IN
cord-342936-43u7afl3	421	3	DC	DC	NNP
cord-342936-43u7afl3	421	4	-	-	HYPH
cord-342936-43u7afl3	421	5	SIGN	SIGN	NNP
cord-342936-43u7afl3	421	6	,	,	,
cord-342936-43u7afl3	421	7	a	a	DT
cord-342936-43u7afl3	421	8	novel	novel	JJ
cord-342936-43u7afl3	421	9	dendritic	dendritic	JJ
cord-342936-43u7afl3	421	10	cell	cell	NN
cord-342936-43u7afl3	421	11	-	-	HYPH
cord-342936-43u7afl3	421	12	specific	specific	JJ
cord-342936-43u7afl3	421	13	ICAM-3	icam-3	JJ
cord-342936-43u7afl3	421	14	receptor	receptor	NN
cord-342936-43u7afl3	421	15	that	that	WDT
cord-342936-43u7afl3	421	16	supports	support	VBZ
cord-342936-43u7afl3	421	17	primary	primary	JJ
cord-342936-43u7afl3	421	18	immune	immune	JJ
cord-342936-43u7afl3	421	19	responses	response	NNS
cord-342936-43u7afl3	421	20	DC	DC	NNP
cord-342936-43u7afl3	421	21	-	-	HYPH
cord-342936-43u7afl3	421	22	SIGN	SIGN	NNP
cord-342936-43u7afl3	421	23	,	,	,
cord-342936-43u7afl3	421	24	a	a	DT
cord-342936-43u7afl3	421	25	dendritic	dendritic	JJ
cord-342936-43u7afl3	421	26	cellspecific	cellspecific	NN
cord-342936-43u7afl3	421	27	HIV-1-binding	hiv-1-binde	VBG
cord-342936-43u7afl3	421	28	protein	protein	NN
cord-342936-43u7afl3	421	29	that	that	WDT
cord-342936-43u7afl3	421	30	enhances	enhance	VBZ
cord-342936-43u7afl3	421	31	transinfection	transinfection	NN
cord-342936-43u7afl3	421	32	of	of	IN
cord-342936-43u7afl3	421	33	T	T	NNP
cord-342936-43u7afl3	421	34	cells	cell	NNS
cord-342936-43u7afl3	421	35	Targeting	target	VBG
cord-342936-43u7afl3	421	36	diversity	diversity	NN
cord-342936-43u7afl3	422	1	The	the	DT
cord-342936-43u7afl3	422	2	broadly	broadly	RB
cord-342936-43u7afl3	422	3	neutralizing	neutralize	VBG
cord-342936-43u7afl3	422	4	antihuman	antihuman	JJ
cord-342936-43u7afl3	422	5	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	422	6	virus	virus	NN
cord-342936-43u7afl3	422	7	type	type	NN
cord-342936-43u7afl3	422	8	1	1	CD
cord-342936-43u7afl3	422	9	antibody	antibody	NN
cord-342936-43u7afl3	422	10	2G12	2g12	CD
cord-342936-43u7afl3	422	11	recognizes	recognize	VBZ
cord-342936-43u7afl3	422	12	a	a	DT
cord-342936-43u7afl3	422	13	cluster	cluster	NN
cord-342936-43u7afl3	422	14	of	of	IN
cord-342936-43u7afl3	422	15	α1→2	α1→2	CD
cord-342936-43u7afl3	422	16	mannose	mannose	JJ
cord-342936-43u7afl3	422	17	residues	residue	NNS
cord-342936-43u7afl3	422	18	on	on	IN
cord-342936-43u7afl3	422	19	the	the	DT
cord-342936-43u7afl3	422	20	outer	outer	JJ
cord-342936-43u7afl3	422	21	face	face	NN
cord-342936-43u7afl3	422	22	of	of	IN
cord-342936-43u7afl3	422	23	gp120	gp120	DT
cord-342936-43u7afl3	422	24	Human	human	JJ
cord-342936-43u7afl3	422	25	monoclonal	monoclonal	JJ
cord-342936-43u7afl3	422	26	antibody	antibody	NN
cord-342936-43u7afl3	422	27	2G12	2g12	CD
cord-342936-43u7afl3	422	28	defines	define	VBZ
cord-342936-43u7afl3	422	29	a	a	DT
cord-342936-43u7afl3	422	30	distinctive	distinctive	JJ
cord-342936-43u7afl3	422	31	neutralization	neutralization	NN
cord-342936-43u7afl3	422	32	epitope	epitope	NN
cord-342936-43u7afl3	422	33	on	on	IN
cord-342936-43u7afl3	422	34	the	the	DT
cord-342936-43u7afl3	422	35	gp120	gp120	NNP
cord-342936-43u7afl3	422	36	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	422	37	of	of	IN
cord-342936-43u7afl3	422	38	human	human	JJ
cord-342936-43u7afl3	422	39	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	422	40	virus	virus	NN
cord-342936-43u7afl3	422	41	type	type	NN
cord-342936-43u7afl3	422	42	1	1	CD
cord-342936-43u7afl3	422	43	Dissection	dissection	NN
cord-342936-43u7afl3	422	44	of	of	IN
cord-342936-43u7afl3	422	45	the	the	DT
cord-342936-43u7afl3	422	46	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	422	47	specificity	specificity	NN
cord-342936-43u7afl3	422	48	of	of	IN
cord-342936-43u7afl3	422	49	the	the	DT
cord-342936-43u7afl3	422	50	broadly	broadly	RB
cord-342936-43u7afl3	422	51	neutralizing	neutralize	VBG
cord-342936-43u7afl3	422	52	anti	anti	JJ
cord-342936-43u7afl3	422	53	-	-	JJ
cord-342936-43u7afl3	422	54	HIVHIV-1	hivhiv-1	JJ
cord-342936-43u7afl3	422	55	antibody	antibody	NN
cord-342936-43u7afl3	422	56	2G12	2g12	CD
cord-342936-43u7afl3	423	1	The	the	DT
cord-342936-43u7afl3	423	2	mannose	mannose	NN
cord-342936-43u7afl3	423	3	-	-	HYPH
cord-342936-43u7afl3	423	4	dependent	dependent	JJ
cord-342936-43u7afl3	423	5	epitope	epitope	NN
cord-342936-43u7afl3	423	6	for	for	IN
cord-342936-43u7afl3	423	7	neutralizing	neutralize	VBG
cord-342936-43u7afl3	423	8	antibody	antibody	NN
cord-342936-43u7afl3	423	9	2G12	2g12	CD
cord-342936-43u7afl3	423	10	on	on	IN
cord-342936-43u7afl3	423	11	human	human	JJ
cord-342936-43u7afl3	423	12	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	423	13	virus	virus	NN
cord-342936-43u7afl3	423	14	type	type	NN
cord-342936-43u7afl3	423	15	1	1	CD
cord-342936-43u7afl3	423	16	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	423	17	gp120	gp120	NNP
cord-342936-43u7afl3	423	18	Antibody	Antibody	NNP
cord-342936-43u7afl3	423	19	domain	domain	NN
cord-342936-43u7afl3	423	20	exchange	exchange	NN
cord-342936-43u7afl3	423	21	is	be	VBZ
cord-342936-43u7afl3	423	22	an	an	DT
cord-342936-43u7afl3	423	23	immunological	immunological	JJ
cord-342936-43u7afl3	423	24	solution	solution	NN
cord-342936-43u7afl3	423	25	to	to	IN
cord-342936-43u7afl3	423	26	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	423	27	cluster	cluster	NN
cord-342936-43u7afl3	423	28	recognition	recognition	NN
cord-342936-43u7afl3	423	29	Resistance	Resistance	NNP
cord-342936-43u7afl3	423	30	of	of	IN
cord-342936-43u7afl3	423	31	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	423	32	to	to	IN
cord-342936-43u7afl3	423	33	the	the	DT
cord-342936-43u7afl3	423	34	broadly	broadly	RB
cord-342936-43u7afl3	423	35	HIV-1-neutralizing	hiv-1-neutralizing	NN
cord-342936-43u7afl3	423	36	,	,	,
cord-342936-43u7afl3	423	37	anti	anti	JJ
cord-342936-43u7afl3	423	38	-	-	JJ
cord-342936-43u7afl3	423	39	carbohydrate	carbohydrate	JJ
cord-342936-43u7afl3	423	40	antibody	antibody	NN
cord-342936-43u7afl3	423	41	2G12	2g12	CD
cord-342936-43u7afl3	423	42	Pradimicin	Pradimicin	NNP
cord-342936-43u7afl3	423	43	,	,	,
cord-342936-43u7afl3	423	44	a	a	DT
cord-342936-43u7afl3	423	45	novel	novel	JJ
cord-342936-43u7afl3	423	46	class	class	NN
cord-342936-43u7afl3	423	47	of	of	IN
cord-342936-43u7afl3	423	48	potent	potent	JJ
cord-342936-43u7afl3	423	49	antifungal	antifungal	JJ
cord-342936-43u7afl3	423	50	antibiotics	antibiotic	NNS
cord-342936-43u7afl3	423	51	Studies	Studies	NNPS
cord-342936-43u7afl3	423	52	on	on	IN
cord-342936-43u7afl3	423	53	the	the	DT
cord-342936-43u7afl3	423	54	mode	mode	NN
cord-342936-43u7afl3	423	55	of	of	IN
cord-342936-43u7afl3	423	56	antifungal	antifungal	JJ
cord-342936-43u7afl3	423	57	action	action	NN
cord-342936-43u7afl3	423	58	of	of	IN
cord-342936-43u7afl3	423	59	pradimicin	pradimicin	NNP
cord-342936-43u7afl3	423	60	antibiotics	antibiotic	NNS
cord-342936-43u7afl3	423	61	.	.	.
cord-342936-43u7afl3	424	1	III	III	NNP
cord-342936-43u7afl3	424	2	.	.	.
cord-342936-43u7afl3	425	1	Spectrophotometric	spectrophotometric	JJ
cord-342936-43u7afl3	425	2	sequence	sequence	NN
cord-342936-43u7afl3	425	3	analysis	analysis	NN
cord-342936-43u7afl3	425	4	of	of	IN
cord-342936-43u7afl3	425	5	the	the	DT
cord-342936-43u7afl3	425	6	ternary	ternary	JJ
cord-342936-43u7afl3	425	7	complex	complex	JJ
cord-342936-43u7afl3	425	8	formation	formation	NN
cord-342936-43u7afl3	425	9	of	of	IN
cord-342936-43u7afl3	425	10	BMY-28864	BMY-28864	NNP
cord-342936-43u7afl3	425	11	with	with	IN
cord-342936-43u7afl3	425	12	D	d	NN
cord-342936-43u7afl3	425	13	-	-	NN
cord-342936-43u7afl3	425	14	mannopyranoside	mannopyranoside	NN
cord-342936-43u7afl3	425	15	and	and	CC
cord-342936-43u7afl3	425	16	calcium	calcium	VB
cord-342936-43u7afl3	425	17	New	new	JJ
cord-342936-43u7afl3	425	18	antifungal	antifungal	JJ
cord-342936-43u7afl3	425	19	antibiotics	antibiotic	NNS
cord-342936-43u7afl3	425	20	,	,	,
cord-342936-43u7afl3	425	21	benanomicins	benanomicins	NNP
cord-342936-43u7afl3	425	22	A	A	NNP
cord-342936-43u7afl3	425	23	and	and	CC
cord-342936-43u7afl3	425	24	B	b	NN
cord-342936-43u7afl3	425	25	from	from	IN
cord-342936-43u7afl3	425	26	an	an	DT
cord-342936-43u7afl3	425	27	actinomycete	actinomycete	JJ
cord-342936-43u7afl3	425	28	New	new	JJ
cord-342936-43u7afl3	425	29	antifungal	antifungal	JJ
cord-342936-43u7afl3	425	30	antibiotics	antibiotic	NNS
cord-342936-43u7afl3	425	31	,	,	,
cord-342936-43u7afl3	425	32	benanomicins	benanomicins	NNP
cord-342936-43u7afl3	425	33	A	A	NNP
cord-342936-43u7afl3	425	34	and	and	CC
cord-342936-43u7afl3	425	35	B	b	NN
cord-342936-43u7afl3	425	36	inhibit	inhibit	VB
cord-342936-43u7afl3	425	37	infection	infection	NN
cord-342936-43u7afl3	425	38	of	of	IN
cord-342936-43u7afl3	425	39	T	t	NN
cord-342936-43u7afl3	425	40	-	-	HYPH
cord-342936-43u7afl3	425	41	cell	cell	NN
cord-342936-43u7afl3	425	42	with	with	IN
cord-342936-43u7afl3	425	43	human	human	JJ
cord-342936-43u7afl3	425	44	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	425	45	virus	virus	NN
cord-342936-43u7afl3	425	46	(	(	-LRB-
cord-342936-43u7afl3	425	47	HIV	HIV	NNP
cord-342936-43u7afl3	425	48	)	)	-RRB-
cord-342936-43u7afl3	425	49	and	and	CC
cord-342936-43u7afl3	425	50	syncytium	syncytium	NN
cord-342936-43u7afl3	425	51	formation	formation	NN
cord-342936-43u7afl3	425	52	by	by	IN
cord-342936-43u7afl3	425	53	HIV	HIV	NNP
cord-342936-43u7afl3	425	54	Pradimicin	Pradimicin	NNP
cord-342936-43u7afl3	426	1	A	a	DT
cord-342936-43u7afl3	426	2	inhibition	inhibition	NN
cord-342936-43u7afl3	426	3	of	of	IN
cord-342936-43u7afl3	426	4	human	human	JJ
cord-342936-43u7afl3	426	5	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	426	6	virus	virus	NN
cord-342936-43u7afl3	426	7	:	:	:
cord-342936-43u7afl3	426	8	attenuation	attenuation	NN
cord-342936-43u7afl3	426	9	by	by	IN
cord-342936-43u7afl3	426	10	mannan	mannan	NNP
cord-342936-43u7afl3	426	11	Pradimicin	Pradimicin	NNP
cord-342936-43u7afl3	426	12	A	A	NNP
cord-342936-43u7afl3	426	13	,	,	,
cord-342936-43u7afl3	426	14	a	a	DT
cord-342936-43u7afl3	426	15	carbohydratebinding	carbohydratebinde	VBG
cord-342936-43u7afl3	426	16	nonpeptidic	nonpeptidic	NNP
cord-342936-43u7afl3	426	17	lead	lead	NNP
cord-342936-43u7afl3	426	18	compound	compound	NNP
cord-342936-43u7afl3	426	19	for	for	IN
cord-342936-43u7afl3	426	20	treatment	treatment	NN
cord-342936-43u7afl3	426	21	of	of	IN
cord-342936-43u7afl3	426	22	infections	infection	NNS
cord-342936-43u7afl3	426	23	with	with	IN
cord-342936-43u7afl3	426	24	viruses	virus	NNS
cord-342936-43u7afl3	426	25	with	with	IN
cord-342936-43u7afl3	426	26	highly	highly	RB
cord-342936-43u7afl3	426	27	glycosylated	glycosylated	JJ
cord-342936-43u7afl3	426	28	envelopes	envelope	NNS
cord-342936-43u7afl3	426	29	,	,	,
cord-342936-43u7afl3	426	30	such	such	JJ
cord-342936-43u7afl3	426	31	as	as	IN
cord-342936-43u7afl3	426	32	human	human	JJ
cord-342936-43u7afl3	426	33	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	426	34	virus	virus	NN
cord-342936-43u7afl3	427	1	A	a	DT
cord-342936-43u7afl3	427	2	sugar	sugar	NN
cord-342936-43u7afl3	427	3	discriminating	discriminate	VBG
cord-342936-43u7afl3	427	4	binuclear	binuclear	NN
cord-342936-43u7afl3	427	5	copper	copper	NN
cord-342936-43u7afl3	427	6	(	(	-LRB-
cord-342936-43u7afl3	427	7	II	II	NNP
cord-342936-43u7afl3	427	8	)	)	-RRB-
cord-342936-43u7afl3	427	9	complex	complex	JJ
cord-342936-43u7afl3	427	10	Molecular	molecular	JJ
cord-342936-43u7afl3	427	11	recognition	recognition	NN
cord-342936-43u7afl3	427	12	of	of	IN
cord-342936-43u7afl3	427	13	carbohydrates	carbohydrate	NNS
cord-342936-43u7afl3	427	14	with	with	IN
cord-342936-43u7afl3	427	15	artificial	artificial	JJ
cord-342936-43u7afl3	427	16	receptors	receptor	NNS
cord-342936-43u7afl3	427	17	:	:	:
cord-342936-43u7afl3	427	18	mimicking	mimic	VBG
cord-342936-43u7afl3	427	19	the	the	DT
cord-342936-43u7afl3	427	20	binding	bind	VBG
cord-342936-43u7afl3	427	21	motifs	motif	NNS
cord-342936-43u7afl3	427	22	found	find	VBN
cord-342936-43u7afl3	427	23	in	in	IN
cord-342936-43u7afl3	427	24	the	the	DT
cord-342936-43u7afl3	427	25	crystal	crystal	NN
cord-342936-43u7afl3	427	26	structures	structure	NNS
cord-342936-43u7afl3	427	27	of	of	IN
cord-342936-43u7afl3	427	28	protein	protein	NN
cord-342936-43u7afl3	427	29	-	-	HYPH
cord-342936-43u7afl3	427	30	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	427	31	complexes	complex	NNS
cord-342936-43u7afl3	427	32	Orientation	Orientation	NNP
cord-342936-43u7afl3	427	33	of	of	IN
cord-342936-43u7afl3	427	34	bound	bound	JJ
cord-342936-43u7afl3	427	35	ligands	ligand	NNS
cord-342936-43u7afl3	427	36	in	in	IN
cord-342936-43u7afl3	427	37	mannose	mannose	NN
cord-342936-43u7afl3	427	38	-	-	HYPH
cord-342936-43u7afl3	427	39	binding	bind	VBG
cord-342936-43u7afl3	427	40	proteins	protein	NNS
cord-342936-43u7afl3	427	41	.	.	.
cord-342936-43u7afl3	428	1	Implications	implication	NNS
cord-342936-43u7afl3	428	2	for	for	IN
cord-342936-43u7afl3	428	3	multivalent	multivalent	JJ
cord-342936-43u7afl3	428	4	ligand	ligand	NN
cord-342936-43u7afl3	428	5	recognition	recognition	NN
cord-342936-43u7afl3	429	1	An	an	DT
cord-342936-43u7afl3	429	2	extensive	extensive	JJ
cord-342936-43u7afl3	429	3	and	and	CC
cord-342936-43u7afl3	429	4	detailed	detailed	JJ
cord-342936-43u7afl3	429	5	overview	overview	NN
cord-342936-43u7afl3	429	6	of	of	IN
cord-342936-43u7afl3	429	7	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	429	8	-	-	HYPH
cord-342936-43u7afl3	429	9	binding	bind	VBG
cord-342936-43u7afl3	429	10	proteins	protein	NNS
cord-342936-43u7afl3	429	11	that	that	WDT
cord-342936-43u7afl3	429	12	interact	interact	VBP
cord-342936-43u7afl3	429	13	with	with	IN
cord-342936-43u7afl3	429	14	the	the	DT
cord-342936-43u7afl3	429	15	HIV	HIV	NNP
cord-342936-43u7afl3	429	16	Structural	Structural	NNP
cord-342936-43u7afl3	429	17	basis	basis	NN
cord-342936-43u7afl3	429	18	for	for	IN
cord-342936-43u7afl3	429	19	selective	selective	JJ
cord-342936-43u7afl3	429	20	recognition	recognition	NN
cord-342936-43u7afl3	429	21	of	of	IN
cord-342936-43u7afl3	429	22	oligosaccharides	oligosaccharide	NNS
cord-342936-43u7afl3	429	23	by	by	IN
cord-342936-43u7afl3	429	24	DC	DC	NNP
cord-342936-43u7afl3	429	25	-	-	HYPH
cord-342936-43u7afl3	429	26	SIGN	SIGN	NNP
cord-342936-43u7afl3	429	27	and	and	CC
cord-342936-43u7afl3	429	28	DC	DC	NNP
cord-342936-43u7afl3	429	29	-	-	HYPH
cord-342936-43u7afl3	429	30	SIGNR	SIGNR	NNP
cord-342936-43u7afl3	429	31	Insights	Insights	NNPS
cord-342936-43u7afl3	429	32	into	into	IN
cord-342936-43u7afl3	429	33	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	429	34	recognition	recognition	NN
cord-342936-43u7afl3	429	35	by	by	IN
cord-342936-43u7afl3	429	36	Narcissus	Narcissus	NNP
cord-342936-43u7afl3	429	37	pseudonarcissus	pseudonarcissus	NN
cord-342936-43u7afl3	429	38	lectin	lectin	NN
cord-342936-43u7afl3	429	39	:	:	:
cord-342936-43u7afl3	429	40	the	the	DT
cord-342936-43u7afl3	429	41	crystal	crystal	JJ
cord-342936-43u7afl3	429	42	structure	structure	NN
cord-342936-43u7afl3	429	43	at	at	IN
cord-342936-43u7afl3	429	44	2	2	CD
cord-342936-43u7afl3	429	45	Å	å	NN
cord-342936-43u7afl3	429	46	resolution	resolution	NN
cord-342936-43u7afl3	429	47	in	in	IN
cord-342936-43u7afl3	429	48	complex	complex	NN
cord-342936-43u7afl3	429	49	with	with	IN
cord-342936-43u7afl3	429	50	α1	α1	NN
cord-342936-43u7afl3	429	51	-	-	HYPH
cord-342936-43u7afl3	429	52	3	3	CD
cord-342936-43u7afl3	429	53	mannobiose	mannobiose	JJ
cord-342936-43u7afl3	429	54	Strucure	Strucure	NNP
cord-342936-43u7afl3	429	55	of	of	IN
cord-342936-43u7afl3	429	56	mannose	mannose	NN
cord-342936-43u7afl3	429	57	-	-	HYPH
cord-342936-43u7afl3	429	58	specific	specific	JJ
cord-342936-43u7afl3	429	59	snowdrop	snowdrop	NN
cord-342936-43u7afl3	429	60	(	(	-LRB-
cord-342936-43u7afl3	429	61	Galanthus	Galanthus	NNP
cord-342936-43u7afl3	429	62	nivalis	nivalis	NN
cord-342936-43u7afl3	429	63	)	)	-RRB-
cord-342936-43u7afl3	429	64	lectin	lectin	NN
cord-342936-43u7afl3	429	65	is	be	VBZ
cord-342936-43u7afl3	429	66	representative	representative	NN
cord-342936-43u7afl3	429	67	of	of	IN
cord-342936-43u7afl3	429	68	a	a	DT
cord-342936-43u7afl3	429	69	new	new	JJ
cord-342936-43u7afl3	429	70	plant	plant	NN
cord-342936-43u7afl3	429	71	lectin	lectin	NN
cord-342936-43u7afl3	429	72	family	family	NN
cord-342936-43u7afl3	429	73	A	a	DT
cord-342936-43u7afl3	429	74	novel	novel	JJ
cord-342936-43u7afl3	429	75	tetrameric	tetrameric	JJ
cord-342936-43u7afl3	429	76	lectin	lectin	NN
cord-342936-43u7afl3	429	77	from	from	IN
cord-342936-43u7afl3	429	78	Lycoris	Lycoris	NNP
cord-342936-43u7afl3	429	79	aurea	aurea	NN
cord-342936-43u7afl3	429	80	with	with	IN
cord-342936-43u7afl3	429	81	four	four	CD
cord-342936-43u7afl3	429	82	mannose	mannose	NN
cord-342936-43u7afl3	429	83	binding	bind	VBG
cord-342936-43u7afl3	429	84	sites	site	NNS
cord-342936-43u7afl3	429	85	per	per	IN
cord-342936-43u7afl3	429	86	monomer	monomer	NN
cord-342936-43u7afl3	429	87	Mutational	mutational	JJ
cord-342936-43u7afl3	429	88	pathways	pathway	NNS
cord-342936-43u7afl3	429	89	,	,	,
cord-342936-43u7afl3	429	90	resistance	resistance	NN
cord-342936-43u7afl3	429	91	profile	profile	NN
cord-342936-43u7afl3	429	92	,	,	,
cord-342936-43u7afl3	429	93	and	and	CC
cord-342936-43u7afl3	429	94	side	side	NN
cord-342936-43u7afl3	429	95	effects	effect	NNS
cord-342936-43u7afl3	429	96	of	of	IN
cord-342936-43u7afl3	429	97	Cyanovirin	Cyanovirin	NNP
cord-342936-43u7afl3	429	98	relative	relative	JJ
cord-342936-43u7afl3	429	99	to	to	IN
cord-342936-43u7afl3	429	100	human	human	JJ
cord-342936-43u7afl3	429	101	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	429	102	virus	virus	NN
cord-342936-43u7afl3	429	103	type	type	NN
cord-342936-43u7afl3	429	104	1	1	CD
cord-342936-43u7afl3	429	105	strains	strain	NNS
cord-342936-43u7afl3	429	106	with	with	IN
cord-342936-43u7afl3	429	107	N	n	CD
cord-342936-43u7afl3	429	108	-	-	HYPH
cord-342936-43u7afl3	429	109	glycan	glycan	NN
cord-342936-43u7afl3	429	110	deletions	deletion	NNS
cord-342936-43u7afl3	429	111	in	in	IN
cord-342936-43u7afl3	429	112	their	-PRON-	PRP$
cord-342936-43u7afl3	429	113	gp120	gp120	NNP
cord-342936-43u7afl3	429	114	envelopes	envelope	NNS
cord-342936-43u7afl3	429	115	Role	role	NN
cord-342936-43u7afl3	429	116	of	of	IN
cord-342936-43u7afl3	429	117	envelope	envelope	NN
cord-342936-43u7afl3	429	118	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	429	119	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	429	120	in	in	IN
cord-342936-43u7afl3	429	121	human	human	JJ
cord-342936-43u7afl3	429	122	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	429	123	virus	virus	NN
cord-342936-43u7afl3	429	124	(	(	-LRB-
cord-342936-43u7afl3	429	125	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	429	126	)	)	-RRB-
cord-342936-43u7afl3	429	127	infectivity	infectivity	NN
cord-342936-43u7afl3	429	128	and	and	CC
cord-342936-43u7afl3	429	129	virus	virus	NN
cord-342936-43u7afl3	429	130	-	-	HYPH
cord-342936-43u7afl3	429	131	induced	induce	VBN
cord-342936-43u7afl3	429	132	cell	cell	NN
cord-342936-43u7afl3	429	133	fusion	fusion	NN
cord-342936-43u7afl3	429	134	Sugar	sugar	NN
cord-342936-43u7afl3	429	135	-	-	HYPH
cord-342936-43u7afl3	429	136	binding	bind	VBG
cord-342936-43u7afl3	429	137	proteins	protein	NNS
cord-342936-43u7afl3	429	138	potently	potently	RB
cord-342936-43u7afl3	429	139	inhibit	inhibit	VBP
cord-342936-43u7afl3	429	140	dendritic	dendritic	JJ
cord-342936-43u7afl3	429	141	cell	cell	NN
cord-342936-43u7afl3	429	142	human	human	JJ
cord-342936-43u7afl3	429	143	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	429	144	virus	virus	NN
cord-342936-43u7afl3	429	145	type	type	NN
cord-342936-43u7afl3	429	146	1	1	CD
cord-342936-43u7afl3	429	147	(	(	-LRB-
cord-342936-43u7afl3	429	148	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	429	149	)	)	-RRB-
cord-342936-43u7afl3	429	150	infection	infection	NN
cord-342936-43u7afl3	429	151	and	and	CC
cord-342936-43u7afl3	429	152	dendritic	dendritic	JJ
cord-342936-43u7afl3	429	153	-	-	HYPH
cord-342936-43u7afl3	429	154	cell	cell	NN
cord-342936-43u7afl3	429	155	-	-	HYPH
cord-342936-43u7afl3	429	156	directed	direct	VBN
cord-342936-43u7afl3	429	157	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	429	158	transfer	transfer	NN
cord-342936-43u7afl3	429	159	Inhibition	inhibition	NN
cord-342936-43u7afl3	429	160	of	of	IN
cord-342936-43u7afl3	429	161	HIV	HIV	NNP
cord-342936-43u7afl3	429	162	entry	entry	NN
cord-342936-43u7afl3	429	163	by	by	IN
cord-342936-43u7afl3	429	164	carbohydratebinding	carbohydratebinde	VBG
cord-342936-43u7afl3	429	165	proteins	protein	NNS
cord-342936-43u7afl3	429	166	Carbohydrate	Carbohydrate	NNP
cord-342936-43u7afl3	429	167	-	-	HYPH
cord-342936-43u7afl3	429	168	binding	bind	VBG
cord-342936-43u7afl3	429	169	agents	agent	NNS
cord-342936-43u7afl3	429	170	efficiently	efficiently	RB
cord-342936-43u7afl3	429	171	prevent	prevent	VBP
cord-342936-43u7afl3	429	172	dendritic	dendritic	JJ
cord-342936-43u7afl3	429	173	cell	cell	NN
cord-342936-43u7afl3	429	174	-	-	HYPH
cord-342936-43u7afl3	429	175	specific	specific	JJ
cord-342936-43u7afl3	429	176	intercellular	intercellular	JJ
cord-342936-43u7afl3	429	177	adhesion	adhesion	NN
cord-342936-43u7afl3	429	178	molecule-3-grabbing	molecule-3-grabbe	VBG
cord-342936-43u7afl3	429	179	nonintegrin	nonintegrin	NNP
cord-342936-43u7afl3	429	180	(	(	-LRB-
cord-342936-43u7afl3	429	181	DC	DC	NNP
cord-342936-43u7afl3	429	182	-	-	HYPH
cord-342936-43u7afl3	429	183	SIGN)-directed	SIGN)-directed	NNP
cord-342936-43u7afl3	429	184	HIVHIV-1	HIVHIV-1	NNP
cord-342936-43u7afl3	429	185	-	-	HYPH
cord-342936-43u7afl3	429	186	1	1	CD
cord-342936-43u7afl3	429	187	DC	DC	NNP
cord-342936-43u7afl3	429	188	-	-	HYPH
cord-342936-43u7afl3	429	189	SIGN	sign	NN
cord-342936-43u7afl3	429	190	:	:	:
cord-342936-43u7afl3	429	191	escape	escape	VB
cord-342936-43u7afl3	429	192	mechanism	mechanism	NN
cord-342936-43u7afl3	429	193	for	for	IN
cord-342936-43u7afl3	429	194	pathogens	pathogen	NNS
cord-342936-43u7afl3	429	195	Anti	anti	JJ
cord-342936-43u7afl3	429	196	-	-	JJ
cord-342936-43u7afl3	429	197	human	human	JJ
cord-342936-43u7afl3	429	198	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	429	199	virus	virus	NN
cord-342936-43u7afl3	429	200	(	(	-LRB-
cord-342936-43u7afl3	429	201	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	429	202	)	)	-RRB-
cord-342936-43u7afl3	429	203	microbicide	microbicide	JJ
cord-342936-43u7afl3	429	204	drug	drug	NN
cord-342936-43u7afl3	429	205	candidates	candidate	NNS
cord-342936-43u7afl3	429	206	to	to	TO
cord-342936-43u7afl3	429	207	prevent	prevent	VB
cord-342936-43u7afl3	429	208	HIV	HIV	NNP
cord-342936-43u7afl3	429	209	infection	infection	NN
cord-342936-43u7afl3	429	210	Maturation	maturation	NN
cord-342936-43u7afl3	429	211	of	of	IN
cord-342936-43u7afl3	429	212	blood	blood	NN
cord-342936-43u7afl3	430	1	derived	derive	VBN
cord-342936-43u7afl3	430	2	dendritic	dendritic	JJ
cord-342936-43u7afl3	430	3	cells	cell	NNS
cord-342936-43u7afl3	430	4	enhances	enhance	VBZ
cord-342936-43u7afl3	430	5	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	430	6	capture	capture	NN
cord-342936-43u7afl3	430	7	and	and	CC
cord-342936-43u7afl3	430	8	transmission	transmission	NN
cord-342936-43u7afl3	430	9	Dendritic	dendritic	JJ
cord-342936-43u7afl3	430	10	cell	cell	NN
cord-342936-43u7afl3	430	11	-	-	HYPH
cord-342936-43u7afl3	430	12	mediated	mediate	VBN
cord-342936-43u7afl3	430	13	trans	trans	JJ
cord-342936-43u7afl3	430	14	-	-	NN
cord-342936-43u7afl3	430	15	enhancement	enhancement	NN
cord-342936-43u7afl3	430	16	of	of	IN
cord-342936-43u7afl3	430	17	human	human	JJ
cord-342936-43u7afl3	430	18	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	430	19	virus	virus	NN
cord-342936-43u7afl3	430	20	type	type	NN
cord-342936-43u7afl3	430	21	1	1	CD
cord-342936-43u7afl3	430	22	infectivity	infectivity	NN
cord-342936-43u7afl3	430	23	is	be	VBZ
cord-342936-43u7afl3	430	24	independent	independent	JJ
cord-342936-43u7afl3	430	25	of	of	IN
cord-342936-43u7afl3	430	26	DC	DC	NNP
cord-342936-43u7afl3	430	27	-	-	HYPH
cord-342936-43u7afl3	430	28	SIGN	SIGN	NNP
cord-342936-43u7afl3	430	29	CD4	CD4	NNP
cord-342936-43u7afl3	430	30	co	co	NN
cord-342936-43u7afl3	430	31	-	-	NN
cord-342936-43u7afl3	430	32	expression	expression	NN
cord-342936-43u7afl3	430	33	regulates	regulate	VBZ
cord-342936-43u7afl3	430	34	DC	DC	NNP
cord-342936-43u7afl3	430	35	-	-	HYPH
cord-342936-43u7afl3	430	36	SIGNmediated	signmediate	VBN
cord-342936-43u7afl3	430	37	transmission	transmission	NN
cord-342936-43u7afl3	430	38	of	of	IN
cord-342936-43u7afl3	430	39	human	human	JJ
cord-342936-43u7afl3	430	40	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	430	41	virus	virus	NN
cord-342936-43u7afl3	430	42	type	type	NN
cord-342936-43u7afl3	431	1	1	1	LS
cord-342936-43u7afl3	431	2	Langerin	Langerin	NNP
cord-342936-43u7afl3	431	3	is	be	VBZ
cord-342936-43u7afl3	431	4	a	a	DT
cord-342936-43u7afl3	431	5	natural	natural	JJ
cord-342936-43u7afl3	431	6	barrier	barrier	NN
cord-342936-43u7afl3	431	7	to	to	IN
cord-342936-43u7afl3	431	8	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	431	9	transmission	transmission	NN
cord-342936-43u7afl3	431	10	by	by	IN
cord-342936-43u7afl3	431	11	Langerhans	Langerhans	NNP
cord-342936-43u7afl3	431	12	cells	cell	VBZ
cord-342936-43u7afl3	431	13	Antibody	Antibody	NNP
cord-342936-43u7afl3	431	14	domain	domain	NN
cord-342936-43u7afl3	431	15	exchange	exchange	NN
cord-342936-43u7afl3	431	16	is	be	VBZ
cord-342936-43u7afl3	431	17	an	an	DT
cord-342936-43u7afl3	431	18	immunological	immunological	JJ
cord-342936-43u7afl3	431	19	solution	solution	NN
cord-342936-43u7afl3	431	20	to	to	IN
cord-342936-43u7afl3	431	21	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	431	22	cluster	cluster	NN
cord-342936-43u7afl3	431	23	recognition	recognition	NN
cord-342936-43u7afl3	431	24	Glycobiology	Glycobiology	NNP
cord-342936-43u7afl3	431	25	at	at	IN
cord-342936-43u7afl3	431	26	Oxford	Oxford	NNP
cord-342936-43u7afl3	431	27	.	.	.
cord-342936-43u7afl3	432	1	A	a	DT
cord-342936-43u7afl3	432	2	personal	personal	JJ
cord-342936-43u7afl3	432	3	view	view	NN
cord-342936-43u7afl3	433	1	The	the	DT
cord-342936-43u7afl3	433	2	α(1	α(1	NNP
cord-342936-43u7afl3	433	3	,	,	,
cord-342936-43u7afl3	433	4	2)-mannosidase	2)-mannosidase	CD
cord-342936-43u7afl3	433	5	I	-PRON-	PRP
cord-342936-43u7afl3	433	6	inhibitor	inhibitor	NN
cord-342936-43u7afl3	433	7	1-deoxymannojirimycin	1-deoxymannojirimycin	CD
cord-342936-43u7afl3	433	8	potentiates	potentiate	VBZ
cord-342936-43u7afl3	433	9	the	the	DT
cord-342936-43u7afl3	433	10	antiviral	antiviral	JJ
cord-342936-43u7afl3	433	11	activity	activity	NN
cord-342936-43u7afl3	433	12	of	of	IN
cord-342936-43u7afl3	433	13	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	433	14	-	-	HYPH
cord-342936-43u7afl3	433	15	binding	bind	VBG
cord-342936-43u7afl3	433	16	agents	agent	NNS
cord-342936-43u7afl3	433	17	against	against	IN
cord-342936-43u7afl3	433	18	wild	wild	JJ
cord-342936-43u7afl3	433	19	-	-	HYPH
cord-342936-43u7afl3	433	20	type	type	NN
cord-342936-43u7afl3	433	21	and	and	CC
cord-342936-43u7afl3	433	22	mutant	mutant	JJ
cord-342936-43u7afl3	433	23	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	433	24	strains	strain	NNS
cord-342936-43u7afl3	433	25	containing	contain	VBG
cord-342936-43u7afl3	433	26	glycan	glycan	NN
cord-342936-43u7afl3	433	27	deletions	deletion	NNS
cord-342936-43u7afl3	433	28	in	in	IN
cord-342936-43u7afl3	433	29	gp120	gp120	NNP
cord-342936-43u7afl3	433	30	Identification	Identification	NNP
cord-342936-43u7afl3	433	31	of	of	IN
cord-342936-43u7afl3	433	32	two	two	CD
cord-342936-43u7afl3	433	33	N	n	CD
cord-342936-43u7afl3	433	34	-	-	HYPH
cord-342936-43u7afl3	433	35	linked	link	VBN
cord-342936-43u7afl3	433	36	glycosylation	glycosylation	NN
cord-342936-43u7afl3	433	37	sites	site	NNS
cord-342936-43u7afl3	433	38	within	within	IN
cord-342936-43u7afl3	433	39	the	the	DT
cord-342936-43u7afl3	433	40	core	core	NN
cord-342936-43u7afl3	433	41	of	of	IN
cord-342936-43u7afl3	433	42	the	the	DT
cord-342936-43u7afl3	433	43	simian	simian	JJ
cord-342936-43u7afl3	433	44	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	433	45	virus	virus	NN
cord-342936-43u7afl3	433	46	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	433	47	whose	whose	WP$
cord-342936-43u7afl3	433	48	removal	removal	NN
cord-342936-43u7afl3	433	49	enhances	enhance	VBZ
cord-342936-43u7afl3	433	50	sensitivity	sensitivity	NN
cord-342936-43u7afl3	433	51	to	to	IN
cord-342936-43u7afl3	433	52	soluble	soluble	JJ
cord-342936-43u7afl3	433	53	CD4	CD4	NNP
cord-342936-43u7afl3	433	54	Profile	Profile	NNP
cord-342936-43u7afl3	433	55	of	of	IN
cord-342936-43u7afl3	433	56	resistance	resistance	NN
cord-342936-43u7afl3	433	57	of	of	IN
cord-342936-43u7afl3	433	58	human	human	JJ
cord-342936-43u7afl3	433	59	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	433	60	virus	virus	NN
cord-342936-43u7afl3	433	61	to	to	IN
cord-342936-43u7afl3	433	62	mannose	mannose	NN
cord-342936-43u7afl3	433	63	-	-	HYPH
cord-342936-43u7afl3	433	64	specific	specific	JJ
cord-342936-43u7afl3	433	65	plant	plant	NN
cord-342936-43u7afl3	433	66	lectins	lectin	NNS
cord-342936-43u7afl3	434	1	Marked	marked	JJ
cord-342936-43u7afl3	434	2	depletion	depletion	NN
cord-342936-43u7afl3	434	3	of	of	IN
cord-342936-43u7afl3	434	4	glycosylation	glycosylation	NN
cord-342936-43u7afl3	434	5	sites	site	NNS
cord-342936-43u7afl3	434	6	in	in	IN
cord-342936-43u7afl3	435	1	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	435	2	gp120	gp120	NNP
cord-342936-43u7afl3	435	3	under	under	IN
cord-342936-43u7afl3	435	4	selection	selection	NN
cord-342936-43u7afl3	435	5	pressure	pressure	NN
cord-342936-43u7afl3	435	6	by	by	IN
cord-342936-43u7afl3	435	7	the	the	DT
cord-342936-43u7afl3	435	8	mannose	mannose	NN
cord-342936-43u7afl3	435	9	-	-	HYPH
cord-342936-43u7afl3	435	10	specific	specific	JJ
cord-342936-43u7afl3	435	11	plant	plant	NN
cord-342936-43u7afl3	435	12	lectins	lectin	NNS
cord-342936-43u7afl3	435	13	of	of	IN
cord-342936-43u7afl3	435	14	Hippeastrum	Hippeastrum	NNP
cord-342936-43u7afl3	435	15	hybrid	hybrid	NN
cord-342936-43u7afl3	435	16	and	and	CC
cord-342936-43u7afl3	435	17	Galanthus	Galanthus	NNP
cord-342936-43u7afl3	435	18	nivalis	nivalis	NN
cord-342936-43u7afl3	435	19	Resistance	Resistance	NNP
cord-342936-43u7afl3	435	20	of	of	IN
cord-342936-43u7afl3	435	21	human	human	JJ
cord-342936-43u7afl3	435	22	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	435	23	virus	virus	NN
cord-342936-43u7afl3	435	24	type	type	NN
cord-342936-43u7afl3	435	25	1	1	CD
cord-342936-43u7afl3	435	26	to	to	IN
cord-342936-43u7afl3	435	27	the	the	DT
cord-342936-43u7afl3	435	28	high	high	JJ
cord-342936-43u7afl3	435	29	-	-	HYPH
cord-342936-43u7afl3	435	30	mannose	mannose	NN
cord-342936-43u7afl3	435	31	binding	bind	VBG
cord-342936-43u7afl3	435	32	agents	agent	NNS
cord-342936-43u7afl3	435	33	Cyanovirin	Cyanovirin	NNP
cord-342936-43u7afl3	435	34	N	N	NNP
cord-342936-43u7afl3	435	35	and	and	CC
cord-342936-43u7afl3	435	36	Concanavalin	Concanavalin	NNP
cord-342936-43u7afl3	435	37	A	A	NNP
cord-342936-43u7afl3	435	38	Assignment	Assignment	NNP
cord-342936-43u7afl3	435	39	of	of	IN
cord-342936-43u7afl3	435	40	intrachain	intrachain	NNP
cord-342936-43u7afl3	435	41	disulphide	disulphide	JJ
cord-342936-43u7afl3	435	42	bonds	bond	NNS
cord-342936-43u7afl3	435	43	and	and	CC
cord-342936-43u7afl3	435	44	characterization	characterization	NN
cord-342936-43u7afl3	435	45	of	of	IN
cord-342936-43u7afl3	435	46	potential	potential	JJ
cord-342936-43u7afl3	435	47	glycosylation	glycosylation	NN
cord-342936-43u7afl3	435	48	sites	site	NNS
cord-342936-43u7afl3	435	49	of	of	IN
cord-342936-43u7afl3	435	50	the	the	DT
cord-342936-43u7afl3	435	51	type	type	NN
cord-342936-43u7afl3	435	52	1	1	CD
cord-342936-43u7afl3	435	53	recombinant	recombinant	JJ
cord-342936-43u7afl3	435	54	human	human	JJ
cord-342936-43u7afl3	435	55	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	435	56	virus	virus	NN
cord-342936-43u7afl3	435	57	envelope	envelope	NN
cord-342936-43u7afl3	435	58	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	435	59	(	(	-LRB-
cord-342936-43u7afl3	435	60	gp120	gp120	NNP
cord-342936-43u7afl3	435	61	)	)	-RRB-
cord-342936-43u7afl3	435	62	expressed	express	VBN
cord-342936-43u7afl3	435	63	in	in	IN
cord-342936-43u7afl3	435	64	Chinese	chinese	JJ
cord-342936-43u7afl3	435	65	hamster	hamster	NN
cord-342936-43u7afl3	435	66	ovary	ovary	NN
cord-342936-43u7afl3	435	67	cells	cell	VBZ
cord-342936-43u7afl3	435	68	A	a	DT
cord-342936-43u7afl3	435	69	general	general	JJ
cord-342936-43u7afl3	435	70	model	model	NN
cord-342936-43u7afl3	435	71	for	for	IN
cord-342936-43u7afl3	435	72	the	the	DT
cord-342936-43u7afl3	435	73	surface	surface	NN
cord-342936-43u7afl3	435	74	glycoproteins	glycoprotein	NNS
cord-342936-43u7afl3	435	75	of	of	IN
cord-342936-43u7afl3	435	76	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	435	77	and	and	CC
cord-342936-43u7afl3	435	78	other	other	JJ
cord-342936-43u7afl3	435	79	retroviruses	retrovirus	NNS
cord-342936-43u7afl3	436	1	Enhanced	enhanced	JJ
cord-342936-43u7afl3	436	2	immunogenicity	immunogenicity	NN
cord-342936-43u7afl3	436	3	of	of	IN
cord-342936-43u7afl3	436	4	a	a	DT
cord-342936-43u7afl3	436	5	human	human	JJ
cord-342936-43u7afl3	436	6	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	436	7	virus	virus	NN
cord-342936-43u7afl3	436	8	type	type	NN
cord-342936-43u7afl3	436	9	1	1	CD
cord-342936-43u7afl3	436	10	env	env	NN
cord-342936-43u7afl3	436	11	DNA	dna	NN
cord-342936-43u7afl3	436	12	vaccine	vaccine	NN
cord-342936-43u7afl3	436	13	by	by	IN
cord-342936-43u7afl3	436	14	manipulating	manipulate	VBG
cord-342936-43u7afl3	436	15	N	n	CD
cord-342936-43u7afl3	436	16	-	-	HYPH
cord-342936-43u7afl3	436	17	glycosylation	glycosylation	NN
cord-342936-43u7afl3	436	18	signals	signal	NNS
cord-342936-43u7afl3	436	19	.	.	.
cord-342936-43u7afl3	437	1	Effects	effect	NNS
cord-342936-43u7afl3	437	2	of	of	IN
cord-342936-43u7afl3	437	3	elimination	elimination	NN
cord-342936-43u7afl3	437	4	of	of	IN
cord-342936-43u7afl3	437	5	the	the	DT
cord-342936-43u7afl3	437	6	V3	V3	NNP
cord-342936-43u7afl3	437	7	306	306	CD
cord-342936-43u7afl3	437	8	glycan	glycan	NN
cord-342936-43u7afl3	437	9	Modified	modify	VBN
cord-342936-43u7afl3	437	10	HIV	HIV	NNP
cord-342936-43u7afl3	437	11	envelope	envelope	NN
cord-342936-43u7afl3	437	12	proteins	protein	NNS
cord-342936-43u7afl3	437	13	with	with	IN
cord-342936-43u7afl3	437	14	enhanced	enhance	VBN
cord-342936-43u7afl3	437	15	binding	binding	NN
cord-342936-43u7afl3	437	16	to	to	IN
cord-342936-43u7afl3	437	17	neutralizing	neutralize	VBG
cord-342936-43u7afl3	437	18	monoclonal	monoclonal	JJ
cord-342936-43u7afl3	437	19	antibodies	antibody	NNS
cord-342936-43u7afl3	438	1	Specific	specific	JJ
cord-342936-43u7afl3	438	2	N	N	NNP
cord-342936-43u7afl3	438	3	-	-	HYPH
cord-342936-43u7afl3	438	4	linked	link	VBN
cord-342936-43u7afl3	438	5	and	and	CC
cord-342936-43u7afl3	438	6	O	o	NN
cord-342936-43u7afl3	438	7	-	-	HYPH
cord-342936-43u7afl3	438	8	linked	link	VBN
cord-342936-43u7afl3	438	9	glycosylation	glycosylation	NN
cord-342936-43u7afl3	438	10	modifications	modification	NNS
cord-342936-43u7afl3	438	11	in	in	IN
cord-342936-43u7afl3	438	12	the	the	DT
cord-342936-43u7afl3	438	13	envelope	envelope	NN
cord-342936-43u7afl3	438	14	VI	VI	NNP
cord-342936-43u7afl3	438	15	domain	domain	NN
cord-342936-43u7afl3	438	16	of	of	IN
cord-342936-43u7afl3	438	17	simian	simian	JJ
cord-342936-43u7afl3	438	18	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	438	19	virus	virus	NN
cord-342936-43u7afl3	438	20	variants	variant	NNS
cord-342936-43u7afl3	438	21	that	that	WDT
cord-342936-43u7afl3	438	22	evolve	evolve	VBP
cord-342936-43u7afl3	438	23	in	in	IN
cord-342936-43u7afl3	438	24	the	the	DT
cord-342936-43u7afl3	438	25	host	host	NN
cord-342936-43u7afl3	438	26	alter	alter	VB
cord-342936-43u7afl3	438	27	recognition	recognition	NN
cord-342936-43u7afl3	438	28	by	by	IN
cord-342936-43u7afl3	438	29	neutralizing	neutralize	VBG
cord-342936-43u7afl3	438	30	antibodies	antibody	NNS
cord-342936-43u7afl3	438	31	Selection	Selection	NNP
cord-342936-43u7afl3	438	32	for	for	IN
cord-342936-43u7afl3	438	33	neutralization	neutralization	NN
cord-342936-43u7afl3	438	34	resistance	resistance	NN
cord-342936-43u7afl3	438	35	of	of	IN
cord-342936-43u7afl3	438	36	the	the	DT
cord-342936-43u7afl3	438	37	simian	simian	JJ
cord-342936-43u7afl3	438	38	human	human	JJ
cord-342936-43u7afl3	438	39	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	438	40	virus	virus	NN
cord-342936-43u7afl3	438	41	sHIVSF33A	shivsf33a	ADD
cord-342936-43u7afl3	438	42	variant	variant	NN
cord-342936-43u7afl3	438	43	in	in	IN
cord-342936-43u7afl3	438	44	vivo	vivo	NN
cord-342936-43u7afl3	438	45	by	by	IN
cord-342936-43u7afl3	438	46	virtue	virtue	NN
cord-342936-43u7afl3	438	47	of	of	IN
cord-342936-43u7afl3	438	48	sequence	sequence	NN
cord-342936-43u7afl3	438	49	changes	change	NNS
cord-342936-43u7afl3	438	50	in	in	IN
cord-342936-43u7afl3	438	51	the	the	DT
cord-342936-43u7afl3	438	52	extracellular	extracellular	JJ
cord-342936-43u7afl3	438	53	envelope	envelope	NN
cord-342936-43u7afl3	438	54	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	438	55	that	that	WDT
cord-342936-43u7afl3	438	56	modify	modify	VBP
cord-342936-43u7afl3	438	57	N	n	CD
cord-342936-43u7afl3	438	58	-	-	HYPH
cord-342936-43u7afl3	438	59	linked	link	VBN
cord-342936-43u7afl3	438	60	glycosylation	glycosylation	NN
cord-342936-43u7afl3	438	61	Assorted	assorted	JJ
cord-342936-43u7afl3	438	62	mutations	mutation	NNS
cord-342936-43u7afl3	438	63	in	in	IN
cord-342936-43u7afl3	438	64	the	the	DT
cord-342936-43u7afl3	438	65	envelope	envelope	NN
cord-342936-43u7afl3	438	66	gene	gene	NN
cord-342936-43u7afl3	438	67	of	of	IN
cord-342936-43u7afl3	438	68	simian	simian	JJ
cord-342936-43u7afl3	438	69	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	438	70	virus	virus	NN
cord-342936-43u7afl3	438	71	lead	lead	NN
cord-342936-43u7afl3	438	72	to	to	IN
cord-342936-43u7afl3	438	73	loss	loss	NN
cord-342936-43u7afl3	438	74	of	of	IN
cord-342936-43u7afl3	438	75	neutralization	neutralization	NN
cord-342936-43u7afl3	438	76	resistance	resistance	NN
cord-342936-43u7afl3	438	77	against	against	IN
cord-342936-43u7afl3	438	78	antibodies	antibody	NNS
cord-342936-43u7afl3	438	79	representing	represent	VBG
cord-342936-43u7afl3	438	80	a	a	DT
cord-342936-43u7afl3	438	81	broad	broad	JJ
cord-342936-43u7afl3	438	82	spectrum	spectrum	NN
cord-342936-43u7afl3	438	83	of	of	IN
cord-342936-43u7afl3	438	84	specificities	specificity	NNS
cord-342936-43u7afl3	438	85	Removal	Removal	NNP
cord-342936-43u7afl3	438	86	of	of	IN
cord-342936-43u7afl3	438	87	N	N	NNP
cord-342936-43u7afl3	438	88	-	-	HYPH
cord-342936-43u7afl3	438	89	linked	link	VBN
cord-342936-43u7afl3	438	90	glycosylation	glycosylation	NN
cord-342936-43u7afl3	438	91	sites	site	NNS
cord-342936-43u7afl3	438	92	in	in	IN
cord-342936-43u7afl3	438	93	the	the	DT
cord-342936-43u7afl3	438	94	V1	v1	JJ
cord-342936-43u7afl3	438	95	region	region	NN
cord-342936-43u7afl3	438	96	of	of	IN
cord-342936-43u7afl3	438	97	simian	simian	JJ
cord-342936-43u7afl3	438	98	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	438	99	virus	virus	NN
cord-342936-43u7afl3	438	100	gp120	gp120	CD
cord-342936-43u7afl3	438	101	results	result	NNS
cord-342936-43u7afl3	438	102	in	in	IN
cord-342936-43u7afl3	438	103	redirection	redirection	NN
cord-342936-43u7afl3	438	104	of	of	IN
cord-342936-43u7afl3	438	105	B	b	NN
cord-342936-43u7afl3	438	106	-	-	HYPH
cord-342936-43u7afl3	438	107	cell	cell	NN
cord-342936-43u7afl3	438	108	responses	response	NNS
cord-342936-43u7afl3	438	109	to	to	IN
cord-342936-43u7afl3	438	110	V3	V3	NNP
cord-342936-43u7afl3	438	111	A	a	DT
cord-342936-43u7afl3	438	112	role	role	NN
cord-342936-43u7afl3	438	113	for	for	IN
cord-342936-43u7afl3	438	114	carbohydrates	carbohydrate	NNS
cord-342936-43u7afl3	438	115	in	in	IN
cord-342936-43u7afl3	438	116	immune	immune	JJ
cord-342936-43u7afl3	438	117	evasion	evasion	NN
cord-342936-43u7afl3	438	118	in	in	IN
cord-342936-43u7afl3	438	119	AIDS	AIDS	NNP
cord-342936-43u7afl3	438	120	Consistent	consistent	JJ
cord-342936-43u7afl3	438	121	patterns	pattern	NNS
cord-342936-43u7afl3	438	122	of	of	IN
cord-342936-43u7afl3	438	123	change	change	NN
cord-342936-43u7afl3	438	124	during	during	IN
cord-342936-43u7afl3	438	125	the	the	DT
cord-342936-43u7afl3	438	126	divergence	divergence	NN
cord-342936-43u7afl3	438	127	of	of	IN
cord-342936-43u7afl3	438	128	human	human	JJ
cord-342936-43u7afl3	438	129	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	438	130	virus	virus	NN
cord-342936-43u7afl3	438	131	type	type	NN
cord-342936-43u7afl3	438	132	1	1	CD
cord-342936-43u7afl3	438	133	envelope	envelope	NN
cord-342936-43u7afl3	438	134	from	from	IN
cord-342936-43u7afl3	438	135	that	that	DT
cord-342936-43u7afl3	438	136	of	of	IN
cord-342936-43u7afl3	438	137	the	the	DT
cord-342936-43u7afl3	438	138	inoculated	inoculate	VBN
cord-342936-43u7afl3	438	139	virus	virus	NN
cord-342936-43u7afl3	438	140	in	in	IN
cord-342936-43u7afl3	438	141	simian	simian	JJ
cord-342936-43u7afl3	438	142	/	/	SYM
cord-342936-43u7afl3	438	143	human	human	JJ
cord-342936-43u7afl3	438	144	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	438	145	virusinfected	virusinfecte	VBN
cord-342936-43u7afl3	438	146	macaques	macaque	NNS
cord-342936-43u7afl3	439	1	Evolutionary	evolutionary	JJ
cord-342936-43u7afl3	439	2	interactions	interaction	NNS
cord-342936-43u7afl3	439	3	between	between	IN
cord-342936-43u7afl3	439	4	N	n	CD
cord-342936-43u7afl3	439	5	-	-	HYPH
cord-342936-43u7afl3	439	6	linked	link	VBN
cord-342936-43u7afl3	439	7	glycosylation	glycosylation	NN
cord-342936-43u7afl3	439	8	sites	site	NNS
cord-342936-43u7afl3	439	9	in	in	IN
cord-342936-43u7afl3	439	10	the	the	DT
cord-342936-43u7afl3	439	11	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	439	12	envelope	envelope	NN
cord-342936-43u7afl3	439	13	Distinct	distinct	JJ
cord-342936-43u7afl3	439	14	functions	function	NNS
cord-342936-43u7afl3	439	15	of	of	IN
cord-342936-43u7afl3	439	16	DC	DC	NNP
cord-342936-43u7afl3	439	17	-	-	HYPH
cord-342936-43u7afl3	439	18	SIGN	SIGN	NNP
cord-342936-43u7afl3	439	19	and	and	CC
cord-342936-43u7afl3	439	20	its	-PRON-	PRP$
cord-342936-43u7afl3	439	21	homologues	homologue	NNS
cord-342936-43u7afl3	439	22	L	l	NN
cord-342936-43u7afl3	439	23	-	-	HYPH
cord-342936-43u7afl3	439	24	SIGN	sign	NN
cord-342936-43u7afl3	440	1	(	(	-LRB-
cord-342936-43u7afl3	440	2	DC	DC	NNP
cord-342936-43u7afl3	440	3	-	-	HYPH
cord-342936-43u7afl3	440	4	SIGNR	SIGNR	NNP
cord-342936-43u7afl3	440	5	)	)	-RRB-
cord-342936-43u7afl3	440	6	and	and	CC
cord-342936-43u7afl3	440	7	mSIGNR1	mSIGNR1	NNP
cord-342936-43u7afl3	440	8	in	in	IN
cord-342936-43u7afl3	440	9	pathogen	pathogen	NN
cord-342936-43u7afl3	440	10	recognition	recognition	NN
cord-342936-43u7afl3	440	11	and	and	CC
cord-342936-43u7afl3	440	12	immune	immune	JJ
cord-342936-43u7afl3	440	13	regulation	regulation	NN
cord-342936-43u7afl3	441	1	DC	DC	NNP
cord-342936-43u7afl3	441	2	-	-	HYPH
cord-342936-43u7afl3	441	3	SIGN	sign	NN
cord-342936-43u7afl3	441	4	(	(	-LRB-
cord-342936-43u7afl3	441	5	CD209	cd209	NN
cord-342936-43u7afl3	441	6	)	)	-RRB-
cord-342936-43u7afl3	441	7	mediates	mediate	VBZ
cord-342936-43u7afl3	441	8	dengue	dengue	NN
cord-342936-43u7afl3	441	9	virus	virus	NN
cord-342936-43u7afl3	441	10	infection	infection	NN
cord-342936-43u7afl3	441	11	of	of	IN
cord-342936-43u7afl3	441	12	human	human	JJ
cord-342936-43u7afl3	441	13	dendritic	dendritic	JJ
cord-342936-43u7afl3	441	14	cells	cell	NNS
cord-342936-43u7afl3	441	15	Human	human	JJ
cord-342936-43u7afl3	441	16	cytomegalovirus	cytomegalovirus	NN
cord-342936-43u7afl3	441	17	binding	bind	VBG
cord-342936-43u7afl3	441	18	to	to	IN
cord-342936-43u7afl3	441	19	DC	DC	NNP
cord-342936-43u7afl3	441	20	-	-	HYPH
cord-342936-43u7afl3	441	21	SIGN	SIGN	NNP
cord-342936-43u7afl3	441	22	is	be	VBZ
cord-342936-43u7afl3	441	23	required	require	VBN
cord-342936-43u7afl3	441	24	for	for	IN
cord-342936-43u7afl3	441	25	dendritic	dendritic	JJ
cord-342936-43u7afl3	441	26	cell	cell	NN
cord-342936-43u7afl3	441	27	infection	infection	NN
cord-342936-43u7afl3	441	28	and	and	CC
cord-342936-43u7afl3	441	29	target	target	NN
cord-342936-43u7afl3	441	30	cell	cell	NN
cord-342936-43u7afl3	441	31	trans	trans	NN
cord-342936-43u7afl3	441	32	-	-	NN
cord-342936-43u7afl3	441	33	infection	infection	NN
cord-342936-43u7afl3	441	34	C	c	NN
cord-342936-43u7afl3	441	35	-	-	HYPH
cord-342936-43u7afl3	441	36	type	type	NN
cord-342936-43u7afl3	441	37	lectins	lectin	NNS
cord-342936-43u7afl3	441	38	L	l	NN
cord-342936-43u7afl3	441	39	-	-	HYPH
cord-342936-43u7afl3	441	40	SIGN	SIGN	NNP
cord-342936-43u7afl3	441	41	and	and	CC
cord-342936-43u7afl3	441	42	DC	DC	NNP
cord-342936-43u7afl3	441	43	-	-	HYPH
cord-342936-43u7afl3	441	44	SIGN	sign	NN
cord-342936-43u7afl3	441	45	capture	capture	NN
cord-342936-43u7afl3	441	46	and	and	CC
cord-342936-43u7afl3	441	47	transmit	transmit	VB
cord-342936-43u7afl3	441	48	infectious	infectious	JJ
cord-342936-43u7afl3	441	49	hepatitis	hepatitis	NN
cord-342936-43u7afl3	441	50	C	c	NN
cord-342936-43u7afl3	441	51	virus	virus	NN
cord-342936-43u7afl3	441	52	pseudotype	pseudotype	NN
cord-342936-43u7afl3	441	53	particles	particle	NNS
cord-342936-43u7afl3	441	54	C	c	NN
cord-342936-43u7afl3	441	55	-	-	HYPH
cord-342936-43u7afl3	441	56	type	type	NN
cord-342936-43u7afl3	441	57	lectins	lectin	NNS
cord-342936-43u7afl3	441	58	DC	DC	NNP
cord-342936-43u7afl3	441	59	-	-	HYPH
cord-342936-43u7afl3	441	60	SIGN	SIGN	NNP
cord-342936-43u7afl3	441	61	and	and	CC
cord-342936-43u7afl3	441	62	L	l	NN
cord-342936-43u7afl3	441	63	-	-	HYPH
cord-342936-43u7afl3	441	64	SIGN	sign	NN
cord-342936-43u7afl3	441	65	mediate	mediate	VB
cord-342936-43u7afl3	441	66	cellular	cellular	JJ
cord-342936-43u7afl3	441	67	entry	entry	NN
cord-342936-43u7afl3	441	68	by	by	IN
cord-342936-43u7afl3	441	69	Ebola	Ebola	NNP
cord-342936-43u7afl3	441	70	virus	virus	NN
cord-342936-43u7afl3	441	71	in	in	IN
cord-342936-43u7afl3	441	72	cis	cis	NNP
cord-342936-43u7afl3	441	73	and	and	CC
cord-342936-43u7afl3	441	74	in	in	IN
cord-342936-43u7afl3	441	75	trans	trans	NNP
cord-342936-43u7afl3	441	76	DC	DC	NNP
cord-342936-43u7afl3	441	77	-	-	HYPH
cord-342936-43u7afl3	441	78	SIGN	SIGN	NNP
cord-342936-43u7afl3	441	79	and	and	CC
cord-342936-43u7afl3	441	80	DC	DC	NNP
cord-342936-43u7afl3	441	81	-	-	HYPH
cord-342936-43u7afl3	441	82	SIGNR	SIGNR	NNP
cord-342936-43u7afl3	441	83	interact	interact	VBP
cord-342936-43u7afl3	441	84	with	with	IN
cord-342936-43u7afl3	441	85	the	the	DT
cord-342936-43u7afl3	441	86	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	441	87	of	of	IN
cord-342936-43u7afl3	441	88	Marburg	Marburg	NNP
cord-342936-43u7afl3	441	89	virus	virus	NN
cord-342936-43u7afl3	441	90	and	and	CC
cord-342936-43u7afl3	441	91	the	the	DT
cord-342936-43u7afl3	441	92	S	S	NNP
cord-342936-43u7afl3	441	93	protein	protein	NN
cord-342936-43u7afl3	441	94	of	of	IN
cord-342936-43u7afl3	442	1	severe	severe	JJ
cord-342936-43u7afl3	442	2	acute	acute	JJ
cord-342936-43u7afl3	442	3	respiratory	respiratory	JJ
cord-342936-43u7afl3	442	4	syndrome	syndrome	NN
cord-342936-43u7afl3	442	5	coronavirus	coronavirus	NN
cord-342936-43u7afl3	442	6	Mycobacteria	Mycobacteria	NNP
cord-342936-43u7afl3	442	7	target	target	VB
cord-342936-43u7afl3	442	8	DC	DC	NNP
cord-342936-43u7afl3	442	9	-	-	HYPH
cord-342936-43u7afl3	442	10	SIGN	sign	NN
cord-342936-43u7afl3	442	11	to	to	TO
cord-342936-43u7afl3	442	12	suppress	suppress	VB
cord-342936-43u7afl3	442	13	dendritic	dendritic	JJ
cord-342936-43u7afl3	442	14	cell	cell	NN
cord-342936-43u7afl3	442	15	function	function	NN
cord-342936-43u7afl3	442	16	DC	DC	NNP
cord-342936-43u7afl3	442	17	-	-	HYPH
cord-342936-43u7afl3	442	18	SIGN	SIGN	NNP
cord-342936-43u7afl3	443	1	is	be	VBZ
cord-342936-43u7afl3	443	2	the	the	DT
cord-342936-43u7afl3	443	3	major	major	JJ
cord-342936-43u7afl3	443	4	Mycobacterium	Mycobacterium	NNP
cord-342936-43u7afl3	443	5	tuberculosis	tuberculosis	NN
cord-342936-43u7afl3	443	6	receptor	receptor	NN
cord-342936-43u7afl3	443	7	on	on	IN
cord-342936-43u7afl3	443	8	human	human	JJ
cord-342936-43u7afl3	443	9	dendritic	dendritic	JJ
cord-342936-43u7afl3	443	10	cells	cell	NNS
cord-342936-43u7afl3	444	1	Selective	selective	JJ
cord-342936-43u7afl3	444	2	probiotic	probiotic	JJ
cord-342936-43u7afl3	444	3	bacteria	bacteria	NNS
cord-342936-43u7afl3	444	4	induce	induce	VBP
cord-342936-43u7afl3	444	5	IL-10-producing	il-10-produce	VBG
cord-342936-43u7afl3	444	6	regulatory	regulatory	JJ
cord-342936-43u7afl3	444	7	T	t	NN
cord-342936-43u7afl3	444	8	cells	cell	NNS
cord-342936-43u7afl3	444	9	in	in	IN
cord-342936-43u7afl3	444	10	vitro	vitro	FW
cord-342936-43u7afl3	444	11	by	by	IN
cord-342936-43u7afl3	444	12	modulating	modulate	VBG
cord-342936-43u7afl3	444	13	dendritic	dendritic	JJ
cord-342936-43u7afl3	444	14	cell	cell	NN
cord-342936-43u7afl3	444	15	function	function	NN
cord-342936-43u7afl3	444	16	through	through	IN
cord-342936-43u7afl3	444	17	dendritic	dendritic	JJ
cord-342936-43u7afl3	444	18	cell	cell	NN
cord-342936-43u7afl3	444	19	-	-	HYPH
cord-342936-43u7afl3	444	20	specific	specific	JJ
cord-342936-43u7afl3	444	21	intercellular	intercellular	JJ
cord-342936-43u7afl3	444	22	adhesion	adhesion	NN
cord-342936-43u7afl3	444	23	molecule	molecule	NN
cord-342936-43u7afl3	444	24	3-grabbing	3-grabbing	CD
cord-342936-43u7afl3	444	25	nonintegrin	nonintegrin	NNP
cord-342936-43u7afl3	444	26	DC	DC	NNP
cord-342936-43u7afl3	444	27	-	-	HYPH
cord-342936-43u7afl3	444	28	SIGN	SIGN	NNP
cord-342936-43u7afl3	445	1	specifically	specifically	RB
cord-342936-43u7afl3	445	2	recognizes	recognize	VBZ
cord-342936-43u7afl3	445	3	Streptococcus	streptococcus	NN
cord-342936-43u7afl3	445	4	pneumoniae	pneumoniae	NN
cord-342936-43u7afl3	445	5	serotypes	serotype	NNS
cord-342936-43u7afl3	445	6	3	3	CD
cord-342936-43u7afl3	445	7	and	and	CC
cord-342936-43u7afl3	445	8	14	14	CD
cord-342936-43u7afl3	445	9	References	reference	NNS
cord-342936-43u7afl3	445	10	46	46	CD
cord-342936-43u7afl3	445	11	and	and	CC
cord-342936-43u7afl3	445	12	47	47	CD
cord-342936-43u7afl3	445	13	provide	provide	VB
cord-342936-43u7afl3	445	14	the	the	DT
cord-342936-43u7afl3	445	15	first	first	JJ
cord-342936-43u7afl3	445	16	identification	identification	NN
cord-342936-43u7afl3	445	17	of	of	IN
cord-342936-43u7afl3	445	18	the	the	DT
cord-342936-43u7afl3	445	19	important	important	JJ
cord-342936-43u7afl3	445	20	role	role	NN
cord-342936-43u7afl3	445	21	of	of	IN
cord-342936-43u7afl3	445	22	the	the	DT
cord-342936-43u7afl3	445	23	natural	natural	JJ
cord-342936-43u7afl3	445	24	C	c	NN
cord-342936-43u7afl3	445	25	-	-	HYPH
cord-342936-43u7afl3	445	26	type	type	NN
cord-342936-43u7afl3	445	27	lectin	lectin	NN
cord-342936-43u7afl3	445	28	DC	DC	NNP
cord-342936-43u7afl3	445	29	-	-	HYPH
cord-342936-43u7afl3	445	30	SIGN	SIGN	NNP
cord-342936-43u7afl3	445	31	in	in	IN
cord-342936-43u7afl3	445	32	innate	innate	JJ
cord-342936-43u7afl3	445	33	pathogen	pathogen	NN
cord-342936-43u7afl3	445	34	recognition	recognition	NN
cord-342936-43u7afl3	445	35	,	,	,
cord-342936-43u7afl3	445	36	capture	capture	NN
cord-342936-43u7afl3	445	37	and	and	CC
cord-342936-43u7afl3	445	38	antigen	antigen	NN
cord-342936-43u7afl3	445	39	presentation	presentation	NN
cord-342936-43u7afl3	445	40	to	to	IN
cord-342936-43u7afl3	445	41	the	the	DT
cord-342936-43u7afl3	445	42	immune	immune	JJ
cord-342936-43u7afl3	445	43	system	system	NN
cord-342936-43u7afl3	446	1	The	the	DT
cord-342936-43u7afl3	446	2	dendritic	dendritic	JJ
cord-342936-43u7afl3	446	3	cell	cell	NN
cord-342936-43u7afl3	446	4	-	-	HYPH
cord-342936-43u7afl3	446	5	specific	specific	JJ
cord-342936-43u7afl3	446	6	C	c	NN
cord-342936-43u7afl3	446	7	-	-	HYPH
cord-342936-43u7afl3	446	8	type	type	NN
cord-342936-43u7afl3	446	9	lectin	lectin	NN
cord-342936-43u7afl3	446	10	DC	DC	NNP
cord-342936-43u7afl3	446	11	-	-	HYPH
cord-342936-43u7afl3	446	12	SIGN	SIGN	NNP
cord-342936-43u7afl3	446	13	is	be	VBZ
cord-342936-43u7afl3	446	14	a	a	DT
cord-342936-43u7afl3	446	15	receptor	receptor	NN
cord-342936-43u7afl3	446	16	for	for	IN
cord-342936-43u7afl3	446	17	Schistosoma	Schistosoma	NNP
cord-342936-43u7afl3	446	18	mansoni	mansoni	NN
cord-342936-43u7afl3	446	19	egg	egg	NN
cord-342936-43u7afl3	446	20	antigens	antigen	NNS
cord-342936-43u7afl3	446	21	and	and	CC
cord-342936-43u7afl3	446	22	recognizes	recognize	VBZ
cord-342936-43u7afl3	446	23	the	the	DT
cord-342936-43u7afl3	446	24	glycan	glycan	NN
cord-342936-43u7afl3	446	25	antigen	antigen	NN
cord-342936-43u7afl3	446	26	Lewis	Lewis	NNP
cord-342936-43u7afl3	446	27	x	x	SYM
cord-342936-43u7afl3	446	28	Helicobacter	Helicobacter	NNP
cord-342936-43u7afl3	446	29	pylori	pylori	NN
cord-342936-43u7afl3	446	30	modulates	modulate	VBZ
cord-342936-43u7afl3	446	31	the	the	DT
cord-342936-43u7afl3	446	32	T	T	NNP
cord-342936-43u7afl3	446	33	helper	helper	NN
cord-342936-43u7afl3	446	34	cell	cell	NN
cord-342936-43u7afl3	446	35	1	1	CD
cord-342936-43u7afl3	446	36	/	/	SYM
cord-342936-43u7afl3	446	37	T	t	NN
cord-342936-43u7afl3	446	38	helper	helper	NN
cord-342936-43u7afl3	446	39	cell	cell	NN
cord-342936-43u7afl3	446	40	2	2	CD
cord-342936-43u7afl3	446	41	balance	balance	NN
cord-342936-43u7afl3	446	42	through	through	IN
cord-342936-43u7afl3	446	43	phase	phase	NN
cord-342936-43u7afl3	446	44	-	-	HYPH
cord-342936-43u7afl3	446	45	variable	variable	NN
cord-342936-43u7afl3	446	46	interaction	interaction	NN
cord-342936-43u7afl3	446	47	between	between	IN
cord-342936-43u7afl3	446	48	lipopolysaccharide	lipopolysaccharide	NN
cord-342936-43u7afl3	446	49	and	and	CC
cord-342936-43u7afl3	446	50	DC	DC	NNP
cord-342936-43u7afl3	446	51	-	-	HYPH
cord-342936-43u7afl3	446	52	SIGN	SIGN	NNP
cord-342936-43u7afl3	446	53	DC	DC	NNP
cord-342936-43u7afl3	446	54	-	-	HYPH
cord-342936-43u7afl3	446	55	SIGN	SIGN	NNP
cord-342936-43u7afl3	446	56	mediates	mediate	VBZ
cord-342936-43u7afl3	446	57	binding	binding	NN
cord-342936-43u7afl3	446	58	of	of	IN
cord-342936-43u7afl3	446	59	dendritic	dendritic	JJ
cord-342936-43u7afl3	446	60	cells	cell	NNS
cord-342936-43u7afl3	446	61	to	to	IN
cord-342936-43u7afl3	446	62	authentic	authentic	JJ
cord-342936-43u7afl3	446	63	pseudo	pseudo	JJ
cord-342936-43u7afl3	446	64	-	-	JJ
cord-342936-43u7afl3	446	65	LewisY	lewisy	JJ
cord-342936-43u7afl3	446	66	glycolipids	glycolipid	NNS
cord-342936-43u7afl3	446	67	of	of	IN
cord-342936-43u7afl3	446	68	Schistosoma	Schistosoma	NNP
cord-342936-43u7afl3	446	69	mansoni	mansoni	NNP
cord-342936-43u7afl3	446	70	cercariae	cercaria	NNS
cord-342936-43u7afl3	446	71	,	,	,
cord-342936-43u7afl3	446	72	the	the	DT
cord-342936-43u7afl3	446	73	first	first	JJ
cord-342936-43u7afl3	446	74	parasitespecific	parasitespecific	NNP
cord-342936-43u7afl3	446	75	ligand	ligand	NN
cord-342936-43u7afl3	446	76	of	of	IN
cord-342936-43u7afl3	446	77	DC	DC	NNP
cord-342936-43u7afl3	446	78	-	-	HYPH
cord-342936-43u7afl3	446	79	SIGN	SIGN	NNP
cord-342936-43u7afl3	446	80	Demonstration	Demonstration	NNP
cord-342936-43u7afl3	446	81	of	of	IN
cord-342936-43u7afl3	446	82	the	the	DT
cord-342936-43u7afl3	446	83	crucial	crucial	JJ
cord-342936-43u7afl3	446	84	importance	importance	NN
cord-342936-43u7afl3	446	85	of	of	IN
cord-342936-43u7afl3	446	86	how	how	WRB
cord-342936-43u7afl3	446	87	a	a	DT
cord-342936-43u7afl3	446	88	continuously	continuously	RB
cord-342936-43u7afl3	446	89	evolving	evolve	VBG
cord-342936-43u7afl3	446	90	glycan	glycan	NN
cord-342936-43u7afl3	446	91	shield	shield	NN
cord-342936-43u7afl3	446	92	on	on	IN
cord-342936-43u7afl3	446	93	the	the	DT
cord-342936-43u7afl3	446	94	HIV	HIV	NNP
cord-342936-43u7afl3	446	95	envelope	envelope	NN
cord-342936-43u7afl3	447	1	gp120	gp120	NNP
cord-342936-43u7afl3	447	2	escapes	escape	VBZ
cord-342936-43u7afl3	447	3	immune	immune	JJ
cord-342936-43u7afl3	447	4	surveillance	surveillance	NN
cord-342936-43u7afl3	447	5	in	in	IN
cord-342936-43u7afl3	447	6	HIV	HIV	NNP
cord-342936-43u7afl3	447	7	Cyanovirin	Cyanovirin	NNP
cord-342936-43u7afl3	447	8	-	-	HYPH
cord-342936-43u7afl3	447	9	N	N	NNP
cord-342936-43u7afl3	448	1	inhibits	inhibit	VBZ
cord-342936-43u7afl3	448	2	hepatitis	hepatitis	NNP
cord-342936-43u7afl3	448	3	C	C	NNP
cord-342936-43u7afl3	448	4	virus	virus	NN
cord-342936-43u7afl3	448	5	entry	entry	NN
cord-342936-43u7afl3	448	6	by	by	IN
cord-342936-43u7afl3	448	7	binding	bind	VBG
cord-342936-43u7afl3	448	8	to	to	IN
cord-342936-43u7afl3	448	9	envelope	envelope	NN
cord-342936-43u7afl3	448	10	protein	protein	NN
cord-342936-43u7afl3	448	11	glycans	glycan	NNS
cord-342936-43u7afl3	449	1	The	the	DT
cord-342936-43u7afl3	449	2	inhibition	inhibition	NN
cord-342936-43u7afl3	449	3	of	of	IN
cord-342936-43u7afl3	449	4	infection	infection	NN
cord-342936-43u7afl3	449	5	and	and	CC
cord-342936-43u7afl3	449	6	entry	entry	NN
cord-342936-43u7afl3	449	7	of	of	IN
cord-342936-43u7afl3	449	8	the	the	DT
cord-342936-43u7afl3	449	9	human	human	JJ
cord-342936-43u7afl3	449	10	immunodeficiency	immunodeficiency	NN
cord-342936-43u7afl3	449	11	virus	virus	NN
cord-342936-43u7afl3	449	12	(	(	-LRB-
cord-342936-43u7afl3	449	13	HIVHIV-1	HIVHIV-1	NNP
cord-342936-43u7afl3	449	14	)	)	-RRB-
cord-342936-43u7afl3	449	15	and	and	CC
cord-342936-43u7afl3	449	16	hepatitis	hepatitis	NNP
cord-342936-43u7afl3	449	17	C	C	NNP
cord-342936-43u7afl3	449	18	virus	virus	NN
cord-342936-43u7afl3	449	19	(	(	-LRB-
cord-342936-43u7afl3	449	20	HCV	HCV	NNP
cord-342936-43u7afl3	449	21	)	)	-RRB-
cord-342936-43u7afl3	449	22	closely	closely	RB
cord-342936-43u7afl3	449	23	correlates	correlate	VBZ
cord-342936-43u7afl3	449	24	for	for	IN
cord-342936-43u7afl3	449	25	carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	449	26	-	-	HYPH
cord-342936-43u7afl3	449	27	binding	bind	VBG
cord-342936-43u7afl3	449	28	agents	agent	NNS
cord-342936-43u7afl3	449	29	(	(	-LRB-
cord-342936-43u7afl3	449	30	CBA	CBA	NNP
cord-342936-43u7afl3	449	31	)	)	-RRB-
cord-342936-43u7afl3	449	32	,	,	,
cord-342936-43u7afl3	449	33	but	but	CC
cord-342936-43u7afl3	449	34	not	not	RB
cord-342936-43u7afl3	449	35	for	for	IN
cord-342936-43u7afl3	449	36	polyanions	polyanion	NNS
cord-342936-43u7afl3	449	37	.	.	.
cord-342936-43u7afl3	450	1	Virology	Virology	NNP
cord-342936-43u7afl3	450	2	(	(	-LRB-
cord-342936-43u7afl3	450	3	in	in	IN
cord-342936-43u7afl3	450	4	the	the	DT
cord-342936-43u7afl3	450	5	press	press	NN
cord-342936-43u7afl3	450	6	)	)	-RRB-
cord-342936-43u7afl3	451	1	Plant	plant	NN
cord-342936-43u7afl3	451	2	lectins	lectin	NNS
cord-342936-43u7afl3	451	3	are	be	VBP
cord-342936-43u7afl3	451	4	potent	potent	JJ
cord-342936-43u7afl3	451	5	inhibitors	inhibitor	NNS
cord-342936-43u7afl3	451	6	of	of	IN
cord-342936-43u7afl3	451	7	coronaviruses	coronaviruse	NNS
cord-342936-43u7afl3	451	8	by	by	IN
cord-342936-43u7afl3	451	9	interfering	interfere	VBG
cord-342936-43u7afl3	451	10	with	with	IN
cord-342936-43u7afl3	451	11	two	two	CD
cord-342936-43u7afl3	451	12	targets	target	NNS
cord-342936-43u7afl3	451	13	in	in	IN
cord-342936-43u7afl3	451	14	the	the	DT
cord-342936-43u7afl3	451	15	viral	viral	JJ
cord-342936-43u7afl3	451	16	replication	replication	NN
cord-342936-43u7afl3	451	17	cycle	cycle	NN
cord-342936-43u7afl3	451	18	Cyanovirin	Cyanovirin	NNP
cord-342936-43u7afl3	451	19	-	-	HYPH
cord-342936-43u7afl3	451	20	N	N	NNP
cord-342936-43u7afl3	451	21	binds	bind	VBZ
cord-342936-43u7afl3	451	22	to	to	IN
cord-342936-43u7afl3	451	23	the	the	DT
cord-342936-43u7afl3	451	24	viral	viral	JJ
cord-342936-43u7afl3	451	25	surface	surface	NN
cord-342936-43u7afl3	451	26	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	451	27	,	,	,
cord-342936-43u7afl3	451	28	GP1	gp1	NN
cord-342936-43u7afl3	451	29	,	,	,
cord-342936-43u7afl3	451	30	2	2	CD
cord-342936-43u7afl3	451	31	and	and	CC
cord-342936-43u7afl3	451	32	inhibits	inhibit	VBZ
cord-342936-43u7afl3	451	33	infectivity	infectivity	NN
cord-342936-43u7afl3	451	34	of	of	IN
cord-342936-43u7afl3	451	35	Ebola	Ebola	NNP
cord-342936-43u7afl3	451	36	virus	virus	NN
cord-342936-43u7afl3	451	37	Safety	Safety	NNP
cord-342936-43u7afl3	451	38	concerns	concern	NNS
cord-342936-43u7afl3	451	39	for	for	IN
cord-342936-43u7afl3	451	40	the	the	DT
cord-342936-43u7afl3	451	41	potential	potential	JJ
cord-342936-43u7afl3	451	42	use	use	NN
cord-342936-43u7afl3	451	43	of	of	IN
cord-342936-43u7afl3	451	44	cyanovirin	cyanovirin	NNP
cord-342936-43u7afl3	451	45	as	as	IN
cord-342936-43u7afl3	451	46	a	a	DT
cord-342936-43u7afl3	451	47	microbicidal	microbicidal	JJ
cord-342936-43u7afl3	451	48	anti	anti	JJ
cord-342936-43u7afl3	451	49	-	-	JJ
cord-342936-43u7afl3	451	50	HIV	hiv	JJ
cord-342936-43u7afl3	451	51	agent	agent	NN
cord-342936-43u7afl3	451	52	in	in	IN
cord-342936-43u7afl3	451	53	Abstracts	abstract	NNS
cord-342936-43u7afl3	451	54	of	of	IN
cord-342936-43u7afl3	451	55	the	the	DT
cord-342936-43u7afl3	451	56	14th	14th	JJ
cord-342936-43u7afl3	451	57	Conference	conference	NN
cord-342936-43u7afl3	451	58	on	on	IN
cord-342936-43u7afl3	451	59	Retroviruses	retrovirus	NNS
cord-342936-43u7afl3	451	60	and	and	CC
cord-342936-43u7afl3	451	61	Opportunistic	opportunistic	JJ
cord-342936-43u7afl3	451	62	Infections	Infections	NNPS
cord-342936-43u7afl3	451	63	Glycosylation	Glycosylation	NNP
cord-342936-43u7afl3	451	64	and	and	CC
cord-342936-43u7afl3	451	65	the	the	DT
cord-342936-43u7afl3	451	66	immune	immune	JJ
cord-342936-43u7afl3	451	67	system	system	NN
cord-342936-43u7afl3	451	68	Dendritic	dendritic	JJ
cord-342936-43u7afl3	451	69	-	-	HYPH
cord-342936-43u7afl3	451	70	cell	cell	NN
cord-342936-43u7afl3	451	71	interactions	interaction	NNS
cord-342936-43u7afl3	451	72	with	with	IN
cord-342936-43u7afl3	451	73	HIV	HIV	NNP
cord-342936-43u7afl3	451	74	:	:	:
cord-342936-43u7afl3	451	75	infection	infection	NN
cord-342936-43u7afl3	451	76	and	and	CC
cord-342936-43u7afl3	451	77	viral	viral	JJ
cord-342936-43u7afl3	451	78	dissemination	dissemination	NN
cord-342936-43u7afl3	451	79	Carbohydrate	carbohydrate	NN
cord-342936-43u7afl3	451	80	-	-	HYPH
cord-342936-43u7afl3	451	81	binding	bind	VBG
cord-342936-43u7afl3	451	82	agents	agent	NNS
cord-342936-43u7afl3	451	83	:	:	:
cord-342936-43u7afl3	451	84	a	a	DT
cord-342936-43u7afl3	451	85	potential	potential	JJ
cord-342936-43u7afl3	451	86	future	future	JJ
cord-342936-43u7afl3	451	87	cornerstone	cornerstone	NN
cord-342936-43u7afl3	451	88	for	for	IN
cord-342936-43u7afl3	451	89	the	the	DT
cord-342936-43u7afl3	451	90	chemotherapy	chemotherapy	NN
cord-342936-43u7afl3	451	91	of	of	IN
cord-342936-43u7afl3	451	92	enveloped	envelop	VBN
cord-342936-43u7afl3	451	93	viruses	virus	NNS
cord-342936-43u7afl3	451	94	?	?	.
cord-342936-43u7afl3	452	1	Dendritic	dendritic	JJ
cord-342936-43u7afl3	452	2	cell	cell	NN
cord-342936-43u7afl3	452	3	-	-	HYPH
cord-342936-43u7afl3	452	4	mediated	mediate	VBN
cord-342936-43u7afl3	452	5	HIV-1	HIV-1	NNP
cord-342936-43u7afl3	452	6	transmission	transmission	NN
cord-342936-43u7afl3	452	7	.	.	.
cord-342936-43u7afl3	453	1	Thesis	Thesis	NNP
cord-342936-43u7afl3	453	2	Structure	Structure	NNP
cord-342936-43u7afl3	453	3	of	of	IN
cord-342936-43u7afl3	453	4	an	an	DT
cord-342936-43u7afl3	453	5	HIV	HIV	NNP
cord-342936-43u7afl3	453	6	gp120	gp120	NNP
cord-342936-43u7afl3	453	7	envelope	envelope	NN
cord-342936-43u7afl3	453	8	glycoprotein	glycoprotein	NN
cord-342936-43u7afl3	453	9	in	in	IN
cord-342936-43u7afl3	453	10	complex	complex	NN
cord-342936-43u7afl3	453	11	with	with	IN
cord-342936-43u7afl3	453	12	the	the	DT
cord-342936-43u7afl3	453	13	CD4	CD4	NNP
cord-342936-43u7afl3	453	14	receptor	receptor	NN
cord-342936-43u7afl3	453	15	and	and	CC
cord-342936-43u7afl3	453	16	a	a	DT
cord-342936-43u7afl3	453	17	neutralizing	neutralize	VBG
cord-342936-43u7afl3	453	18	human	human	JJ
cord-342936-43u7afl3	453	19	antibody	antibody	NN
cord-342936-43u7afl3	453	20	Hepatitis	Hepatitis	NNP
cord-342936-43u7afl3	453	21	C	C	NNP
cord-342936-43u7afl3	453	22	virus	virus	NN
cord-342936-43u7afl3	453	23	targets	target	VBZ
cord-342936-43u7afl3	453	24	DC	DC	NNP
cord-342936-43u7afl3	453	25	-	-	HYPH
cord-342936-43u7afl3	453	26	SIGN	SIGN	NNP
cord-342936-43u7afl3	453	27	and	and	CC
cord-342936-43u7afl3	453	28	L	l	NN
cord-342936-43u7afl3	453	29	-	-	HYPH
cord-342936-43u7afl3	453	30	SIGN	sign	NN
cord-342936-43u7afl3	453	31	to	to	TO
cord-342936-43u7afl3	453	32	escape	escape	VB
cord-342936-43u7afl3	453	33	lysosomal	lysosomal	JJ
cord-342936-43u7afl3	453	34	degradation	degradation	NN
cord-342936-43u7afl3	453	35	West	West	NNP
cord-342936-43u7afl3	453	36	Nile	Nile	NNP
cord-342936-43u7afl3	453	37	virus	virus	NN
cord-342936-43u7afl3	454	1	discriminates	discriminate	NNS
cord-342936-43u7afl3	454	2	between	between	IN
cord-342936-43u7afl3	454	3	DC	DC	NNP
cord-342936-43u7afl3	454	4	-	-	HYPH
cord-342936-43u7afl3	454	5	SIGN	SIGN	NNP
cord-342936-43u7afl3	454	6	and	and	CC
cord-342936-43u7afl3	454	7	DC	DC	NNP
cord-342936-43u7afl3	454	8	-	-	HYPH
cord-342936-43u7afl3	454	9	SIGNR	SIGNR	NNP
cord-342936-43u7afl3	454	10	for	for	IN
cord-342936-43u7afl3	454	11	cellular	cellular	JJ
cord-342936-43u7afl3	454	12	attachment	attachment	NN
cord-342936-43u7afl3	454	13	and	and	CC
cord-342936-43u7afl3	454	14	infection	infection	NN
cord-342936-43u7afl3	455	1	The	the	DT
cord-342936-43u7afl3	455	2	role	role	NN
cord-342936-43u7afl3	455	3	of	of	IN
cord-342936-43u7afl3	455	4	DC	DC	NNP
cord-342936-43u7afl3	455	5	-	-	HYPH
cord-342936-43u7afl3	455	6	SIGN	SIGN	NNP
cord-342936-43u7afl3	455	7	and	and	CC
cord-342936-43u7afl3	455	8	DC	DC	NNP
cord-342936-43u7afl3	455	9	-	-	HYPH
cord-342936-43u7afl3	455	10	SIGNR	SIGNR	NNP
cord-342936-43u7afl3	455	11	in	in	IN
cord-342936-43u7afl3	455	12	HIV	HIV	NNP
cord-342936-43u7afl3	455	13	and	and	CC
cord-342936-43u7afl3	455	14	Ebola	Ebola	NNP
cord-342936-43u7afl3	455	15	virus	virus	NN
cord-342936-43u7afl3	455	16	infection	infection	NN
cord-342936-43u7afl3	455	17	:	:	:
cord-342936-43u7afl3	455	18	can	can	MD
cord-342936-43u7afl3	455	19	potential	potential	JJ
cord-342936-43u7afl3	455	20	therapeutics	therapeutic	NNS
cord-342936-43u7afl3	455	21	block	block	NN
cord-342936-43u7afl3	455	22	virus	virus	NN
cord-342936-43u7afl3	455	23	transmission	transmission	NN
cord-342936-43u7afl3	455	24	and	and	CC
cord-342936-43u7afl3	455	25	dissemination	dissemination	NN
cord-342936-43u7afl3	455	26	?	?	.
cord-342936-43u7afl3	456	1	DC	DC	NNP
cord-342936-43u7afl3	456	2	-	-	HYPH
cord-342936-43u7afl3	456	3	SIGN	SIGN	NNP
cord-342936-43u7afl3	456	4	is	be	VBZ
cord-342936-43u7afl3	456	5	a	a	DT
cord-342936-43u7afl3	456	6	receptor	receptor	NN
cord-342936-43u7afl3	456	7	for	for	IN
cord-342936-43u7afl3	456	8	human	human	JJ
cord-342936-43u7afl3	456	9	herpes	herpes	NNP
cord-342936-43u7afl3	456	10	virus	virus	NN
cord-342936-43u7afl3	456	11	8	8	CD
cord-342936-43u7afl3	456	12	on	on	IN
cord-342936-43u7afl3	456	13	dendritic	dendritic	JJ
cord-342936-43u7afl3	456	14	cells	cell	NNS
cord-342936-43u7afl3	456	15	and	and	CC
cord-342936-43u7afl3	456	16	macrophages	macrophage	NNS
cord-342936-43u7afl3	456	17	Measles	Measles	NNP
cord-342936-43u7afl3	456	18	virus	virus	NN
cord-342936-43u7afl3	456	19	targets	target	VBZ
cord-342936-43u7afl3	456	20	DC	DC	NNP
cord-342936-43u7afl3	456	21	-	-	HYPH
cord-342936-43u7afl3	456	22	SIGN	sign	NN
cord-342936-43u7afl3	456	23	to	to	TO
cord-342936-43u7afl3	456	24	enhance	enhance	VB
cord-342936-43u7afl3	456	25	dendritic	dendritic	JJ
cord-342936-43u7afl3	456	26	cell	cell	NN
cord-342936-43u7afl3	456	27	infection	infection	NN
cord-342936-43u7afl3	456	28	DC	DC	NNP
cord-342936-43u7afl3	456	29	-	-	HYPH
cord-342936-43u7afl3	456	30	SIGN	SIGN	NNP
cord-342936-43u7afl3	456	31	interacts	interact	VBZ
cord-342936-43u7afl3	456	32	with	with	IN
cord-342936-43u7afl3	456	33	Mycobacterium	Mycobacterium	NNP
cord-342936-43u7afl3	456	34	leprae	leprae	NNP
cord-342936-43u7afl3	456	35	but	but	CC
cord-342936-43u7afl3	457	1	sequence	sequence	NN
cord-342936-43u7afl3	457	2	variation	variation	NN
cord-342936-43u7afl3	457	3	in	in	IN
cord-342936-43u7afl3	457	4	this	this	DT
cord-342936-43u7afl3	457	5	lectin	lectin	NN
cord-342936-43u7afl3	457	6	is	be	VBZ
cord-342936-43u7afl3	457	7	not	not	RB
cord-342936-43u7afl3	457	8	associated	associate	VBN
cord-342936-43u7afl3	457	9	with	with	IN
cord-342936-43u7afl3	457	10	leprosy	leprosy	NN
cord-342936-43u7afl3	457	11	in	in	IN
cord-342936-43u7afl3	457	12	the	the	DT
cord-342936-43u7afl3	457	13	Pakistani	pakistani	JJ
cord-342936-43u7afl3	457	14	population	population	NN
cord-342936-43u7afl3	457	15	Role	role	NN
cord-342936-43u7afl3	457	16	of	of	IN
cord-342936-43u7afl3	457	17	the	the	DT
cord-342936-43u7afl3	457	18	C	c	NN
cord-342936-43u7afl3	457	19	-	-	HYPH
cord-342936-43u7afl3	457	20	type	type	NN
cord-342936-43u7afl3	457	21	lectins	lectin	NNS
cord-342936-43u7afl3	458	1	DC	DC	NNP
cord-342936-43u7afl3	458	2	-	-	HYPH
cord-342936-43u7afl3	458	3	SIGN	SIGN	NNP
cord-342936-43u7afl3	458	4	and	and	CC
cord-342936-43u7afl3	458	5	L	l	NN
cord-342936-43u7afl3	458	6	-	-	HYPH
cord-342936-43u7afl3	458	7	SIGN	SIGN	NNP
cord-342936-43u7afl3	458	8	in	in	IN
cord-342936-43u7afl3	458	9	Leishmania	Leishmania	NNP
cord-342936-43u7afl3	458	10	interaction	interaction	NN
cord-342936-43u7afl3	458	11	with	with	IN
cord-342936-43u7afl3	458	12	host	host	NN
cord-342936-43u7afl3	458	13	phagocytes	phagocyte	NNS
cord-342936-43u7afl3	458	14	DC	DC	NNP
cord-342936-43u7afl3	458	15	-	-	HYPH
cord-342936-43u7afl3	458	16	SIGN	SIGN	NNP
cord-342936-43u7afl3	458	17	mediates	mediate	VBZ
cord-342936-43u7afl3	458	18	the	the	DT
cord-342936-43u7afl3	458	19	binding	binding	NN
cord-342936-43u7afl3	458	20	of	of	IN
cord-342936-43u7afl3	458	21	Aspergillus	aspergillus	NN
cord-342936-43u7afl3	458	22	fumigatus	fumigatus	NN
cord-342936-43u7afl3	458	23	and	and	CC
cord-342936-43u7afl3	458	24	keratinophylic	keratinophylic	JJ
cord-342936-43u7afl3	458	25	fungi	fungus	NNS
cord-342936-43u7afl3	458	26	by	by	IN
cord-342936-43u7afl3	458	27	human	human	JJ
cord-342936-43u7afl3	458	28	dendritic	dendritic	JJ
cord-342936-43u7afl3	458	29	cells	cell	NNS
cord-342936-43u7afl3	459	1	The	the	DT
cord-342936-43u7afl3	459	2	C	c	NN
cord-342936-43u7afl3	459	3	-	-	HYPH
cord-342936-43u7afl3	459	4	type	type	NN
cord-342936-43u7afl3	459	5	lectin	lectin	NN
cord-342936-43u7afl3	459	6	DC	DC	NNP
cord-342936-43u7afl3	459	7	-	-	HYPH
cord-342936-43u7afl3	459	8	SIGN	SIGN	NNP
cord-342936-43u7afl3	459	9	(	(	-LRB-
cord-342936-43u7afl3	459	10	CD209	cd209	NN
cord-342936-43u7afl3	459	11	)	)	-RRB-
cord-342936-43u7afl3	459	12	is	be	VBZ
cord-342936-43u7afl3	459	13	an	an	DT
cord-342936-43u7afl3	459	14	antigen	antigen	NN
cord-342936-43u7afl3	459	15	-	-	HYPH
cord-342936-43u7afl3	459	16	uptake	uptake	NN
cord-342936-43u7afl3	459	17	receptor	receptor	NN
cord-342936-43u7afl3	459	18	for	for	IN
cord-342936-43u7afl3	459	19	Candida	Candida	NNP
cord-342936-43u7afl3	459	20	albicans	albican	NNS
cord-342936-43u7afl3	459	21	on	on	IN
cord-342936-43u7afl3	459	22	dendritic	dendritic	JJ
cord-342936-43u7afl3	459	23	cells	cell	NNS
cord-342936-43u7afl3	460	1	The	the	DT
cord-342936-43u7afl3	460	2	research	research	NN
cord-342936-43u7afl3	460	3	of	of	IN
cord-342936-43u7afl3	460	4	the	the	DT
cord-342936-43u7afl3	460	5	author	author	NN
cord-342936-43u7afl3	460	6	has	have	VBZ
cord-342936-43u7afl3	460	7	been	be	VBN
cord-342936-43u7afl3	460	8	supported	support	VBN
cord-342936-43u7afl3	460	9	by	by	IN
cord-342936-43u7afl3	460	10	grants	grant	NNS
cord-342936-43u7afl3	460	11	from	from	IN
cord-342936-43u7afl3	460	12	the	the	DT
cord-342936-43u7afl3	460	13	Rega	Rega	NNP
cord-342936-43u7afl3	460	14	Center	Center	NNP
cord-342936-43u7afl3	460	15	of	of	IN
cord-342936-43u7afl3	460	16	Excellence	Excellence	NNP
cord-342936-43u7afl3	460	17	at	at	IN
cord-342936-43u7afl3	460	18	the	the	DT
cord-342936-43u7afl3	460	19	Katholieke	Katholieke	NNP
cord-342936-43u7afl3	460	20	Universiteit	Universiteit	NNP
cord-342936-43u7afl3	460	21	Leuven	Leuven	NNP
cord-342936-43u7afl3	460	22	,	,	,
cord-342936-43u7afl3	460	23	the	the	DT
cord-342936-43u7afl3	460	24	Geconcerteerde	Geconcerteerde	NNP
cord-342936-43u7afl3	460	25	Onderzoeksacties	Onderzoeksacties	NNP
cord-342936-43u7afl3	460	26	and	and	CC
cord-342936-43u7afl3	460	27	the	the	DT
cord-342936-43u7afl3	460	28	European	European	NNP
cord-342936-43u7afl3	460	29	Commission	Commission	NNP
cord-342936-43u7afl3	460	30	.	.	.
cord-342936-43u7afl3	461	1	D.	D.	NNP
cord-342936-43u7afl3	461	2	Schols	Schols	NNP
cord-342936-43u7afl3	461	3	and	and	CC
cord-342936-43u7afl3	461	4	S.	S.	NNP
cord-342936-43u7afl3	461	5	Liekens	Liekens	NNP
cord-342936-43u7afl3	461	6	,	,	,
cord-342936-43u7afl3	461	7	Rega	Rega	NNP
cord-342936-43u7afl3	461	8	Institute	Institute	NNP
cord-342936-43u7afl3	461	9	,	,	,
cord-342936-43u7afl3	461	10	Leuven	Leuven	NNP
cord-342936-43u7afl3	461	11	,	,	,
cord-342936-43u7afl3	461	12	Belgium	Belgium	NNP
cord-342936-43u7afl3	461	13	,	,	,
cord-342936-43u7afl3	461	14	are	be	VBP
cord-342936-43u7afl3	461	15	acknowledged	acknowledge	VBN
cord-342936-43u7afl3	461	16	for	for	IN
cord-342936-43u7afl3	461	17	the	the	DT
cord-342936-43u7afl3	461	18	critical	critical	JJ
cord-342936-43u7afl3	461	19	reading	reading	NN
cord-342936-43u7afl3	461	20	of	of	IN
cord-342936-43u7afl3	461	21	the	the	DT
cord-342936-43u7afl3	461	22	manuscript	manuscript	NN
cord-342936-43u7afl3	461	23	and	and	CC
cord-342936-43u7afl3	461	24	valuable	valuable	JJ
cord-342936-43u7afl3	461	25	discussions	discussion	NNS
cord-342936-43u7afl3	461	26	.	.	.
cord-342936-43u7afl3	462	1	I	-PRON-	PRP
cord-342936-43u7afl3	462	2	thank	thank	VBP
cord-342936-43u7afl3	462	3	C.	C.	NNP
cord-342936-43u7afl3	462	4	Callebaut	Callebaut	NNP
cord-342936-43u7afl3	462	5	and	and	CC
cord-342936-43u7afl3	462	6	C.	C.	NNP
cord-342936-43u7afl3	462	7	Biernaux	Biernaux	NNP
cord-342936-43u7afl3	462	8	for	for	IN
cord-342936-43u7afl3	462	9	their	-PRON-	PRP$
cord-342936-43u7afl3	462	10	dedicated	dedicated	JJ
cord-342936-43u7afl3	462	11	editorial	editorial	NN
cord-342936-43u7afl3	462	12	help	help	NN
cord-342936-43u7afl3	462	13	.	.	.
cord-342936-43u7afl3	463	1	The	the	DT
cord-342936-43u7afl3	463	2	authors	author	NNS
cord-342936-43u7afl3	463	3	declare	declare	VBP
cord-342936-43u7afl3	463	4	no	no	DT
cord-342936-43u7afl3	463	5	competing	compete	VBG
cord-342936-43u7afl3	463	6	financial	financial	JJ
cord-342936-43u7afl3	463	7	interests	interest	NNS
cord-342936-43u7afl3	463	8	.	.	.
cord-342936-43u7afl3	463	9	 	 	_SP