id sid tid token lemma pos cord-334454-cqaado3u 1 1 key key NN cord-334454-cqaado3u 1 2 : : : cord-334454-cqaado3u 2 1 cord-334454-cqaado3u cord-334454-cqaado3u NNP cord-334454-cqaado3u 2 2 authors author NNS cord-334454-cqaado3u 2 3 : : : cord-334454-cqaado3u 2 4 Leal Leal NNP cord-334454-cqaado3u 2 5 , , , cord-334454-cqaado3u 2 6 Rodolfo Rodolfo NNP cord-334454-cqaado3u 2 7 Oliveira Oliveira NNP cord-334454-cqaado3u 2 8 ; ; : cord-334454-cqaado3u 2 9 Gil Gil NNP cord-334454-cqaado3u 2 10 , , , cord-334454-cqaado3u 3 1 Solange Solange NNP cord-334454-cqaado3u 3 2 title title NN cord-334454-cqaado3u 3 3 : : : cord-334454-cqaado3u 4 1 The the DT cord-334454-cqaado3u 4 2 Use Use NNP cord-334454-cqaado3u 4 3 of of IN cord-334454-cqaado3u 4 4 Recombinant recombinant JJ cord-334454-cqaado3u 4 5 Feline Feline NNP cord-334454-cqaado3u 4 6 Interferon Interferon NNP cord-334454-cqaado3u 4 7 Omega Omega NNP cord-334454-cqaado3u 4 8 Therapy Therapy NNP cord-334454-cqaado3u 4 9 as as IN cord-334454-cqaado3u 4 10 an an DT cord-334454-cqaado3u 4 11 Immune Immune NNP cord-334454-cqaado3u 4 12 - - HYPH cord-334454-cqaado3u 4 13 Modulator modulator NN cord-334454-cqaado3u 4 14 in in IN cord-334454-cqaado3u 4 15 Cats Cats NNPS cord-334454-cqaado3u 4 16 Naturally naturally RB cord-334454-cqaado3u 4 17 Infected infect VBN cord-334454-cqaado3u 4 18 with with IN cord-334454-cqaado3u 4 19 Feline feline JJ cord-334454-cqaado3u 4 20 Immunodeficiency Immunodeficiency NNP cord-334454-cqaado3u 4 21 Virus Virus NNP cord-334454-cqaado3u 4 22 : : : cord-334454-cqaado3u 4 23 New new JJ cord-334454-cqaado3u 4 24 Perspectives Perspectives NNPS cord-334454-cqaado3u 4 25 date date NN cord-334454-cqaado3u 4 26 : : : cord-334454-cqaado3u 4 27 2016 2016 CD cord-334454-cqaado3u 4 28 - - SYM cord-334454-cqaado3u 4 29 10 10 CD cord-334454-cqaado3u 4 30 - - SYM cord-334454-cqaado3u 4 31 27 27 CD cord-334454-cqaado3u 4 32 journal journal NN cord-334454-cqaado3u 4 33 : : : cord-334454-cqaado3u 5 1 Vet Vet NNP cord-334454-cqaado3u 5 2 Sci Sci NNP cord-334454-cqaado3u 5 3 DOI DOI NNP cord-334454-cqaado3u 5 4 : : : cord-334454-cqaado3u 5 5 10.3390 10.3390 CD cord-334454-cqaado3u 5 6 / / SYM cord-334454-cqaado3u 5 7 vetsci3040032 vetsci3040032 NNP cord-334454-cqaado3u 5 8 sha sha NNP cord-334454-cqaado3u 5 9 : : : cord-334454-cqaado3u 6 1 8041d586dc357d38fb7e13f528d400a14ae64b8d 8041d586dc357d38fb7e13f528d400a14ae64b8d NNP cord-334454-cqaado3u 6 2 doc_id doc_id CD cord-334454-cqaado3u 6 3 : : : cord-334454-cqaado3u 6 4 334454 334454 CD cord-334454-cqaado3u 6 5 cord_uid cord_uid NNS cord-334454-cqaado3u 6 6 : : : cord-334454-cqaado3u 7 1 cqaado3u cqaado3u NNP cord-334454-cqaado3u 8 1 Type type NN cord-334454-cqaado3u 8 2 I -PRON- PRP cord-334454-cqaado3u 8 3 interferons interferon NNS cord-334454-cqaado3u 8 4 ( ( -LRB- cord-334454-cqaado3u 8 5 IFNs IFNs NNP cord-334454-cqaado3u 8 6 ) ) -RRB- cord-334454-cqaado3u 8 7 are be VBP cord-334454-cqaado3u 8 8 well well RB cord-334454-cqaado3u 8 9 - - HYPH cord-334454-cqaado3u 8 10 known know VBN cord-334454-cqaado3u 8 11 cytokines cytokine NNS cord-334454-cqaado3u 8 12 that that WDT cord-334454-cqaado3u 8 13 , , , cord-334454-cqaado3u 8 14 among among IN cord-334454-cqaado3u 8 15 their -PRON- PRP$ cord-334454-cqaado3u 8 16 main main JJ cord-334454-cqaado3u 8 17 functions function NNS cord-334454-cqaado3u 8 18 , , , cord-334454-cqaado3u 8 19 are be VBP cord-334454-cqaado3u 8 20 key key JJ cord-334454-cqaado3u 8 21 components component NNS cord-334454-cqaado3u 8 22 of of IN cord-334454-cqaado3u 8 23 the the DT cord-334454-cqaado3u 8 24 host host NN cord-334454-cqaado3u 8 25 immune immune JJ cord-334454-cqaado3u 8 26 response response NN cord-334454-cqaado3u 8 27 against against IN cord-334454-cqaado3u 8 28 viral viral JJ cord-334454-cqaado3u 8 29 infections infection NNS cord-334454-cqaado3u 8 30 . . . cord-334454-cqaado3u 9 1 Due due IN cord-334454-cqaado3u 9 2 to to IN cord-334454-cqaado3u 9 3 its -PRON- PRP$ cord-334454-cqaado3u 9 4 immune immune JJ cord-334454-cqaado3u 9 5 modulation modulation NN cord-334454-cqaado3u 9 6 properties property NNS cord-334454-cqaado3u 9 7 , , , cord-334454-cqaado3u 9 8 they -PRON- PRP cord-334454-cqaado3u 9 9 are be VBP cord-334454-cqaado3u 9 10 commonly commonly RB cord-334454-cqaado3u 9 11 used use VBN cord-334454-cqaado3u 9 12 in in IN cord-334454-cqaado3u 9 13 the the DT cord-334454-cqaado3u 9 14 therapeutic therapeutic JJ cord-334454-cqaado3u 9 15 approach approach NN cord-334454-cqaado3u 9 16 of of IN cord-334454-cqaado3u 9 17 various various JJ cord-334454-cqaado3u 9 18 retroviral retroviral JJ cord-334454-cqaado3u 9 19 infections infection NNS cord-334454-cqaado3u 9 20 , , , cord-334454-cqaado3u 9 21 namely namely RB cord-334454-cqaado3u 9 22 human human JJ cord-334454-cqaado3u 9 23 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 9 24 virus virus NN cord-334454-cqaado3u 9 25 ( ( -LRB- cord-334454-cqaado3u 9 26 HIV HIV NNP cord-334454-cqaado3u 9 27 ) ) -RRB- cord-334454-cqaado3u 9 28 and and CC cord-334454-cqaado3u 9 29 feline feline JJ cord-334454-cqaado3u 9 30 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 9 31 virus virus NN cord-334454-cqaado3u 9 32 ( ( -LRB- cord-334454-cqaado3u 9 33 FIV FIV NNP cord-334454-cqaado3u 9 34 ) ) -RRB- cord-334454-cqaado3u 9 35 . . . cord-334454-cqaado3u 10 1 In in IN cord-334454-cqaado3u 10 2 HIV HIV NNP cord-334454-cqaado3u 10 3 infection infection NN cord-334454-cqaado3u 10 4 , , , cord-334454-cqaado3u 10 5 it -PRON- PRP cord-334454-cqaado3u 10 6 has have VBZ cord-334454-cqaado3u 10 7 been be VBN cord-334454-cqaado3u 10 8 shown show VBN cord-334454-cqaado3u 10 9 that that IN cord-334454-cqaado3u 10 10 IFN IFN NNP cord-334454-cqaado3u 10 11 therapy therapy NN cord-334454-cqaado3u 10 12 limits limit VBZ cord-334454-cqaado3u 10 13 early early JJ cord-334454-cqaado3u 10 14 viral viral JJ cord-334454-cqaado3u 10 15 replication replication NN cord-334454-cqaado3u 10 16 , , , cord-334454-cqaado3u 10 17 particularly particularly RB cord-334454-cqaado3u 10 18 useful useful JJ cord-334454-cqaado3u 10 19 on on IN cord-334454-cqaado3u 10 20 post post JJ cord-334454-cqaado3u 10 21 - - JJ cord-334454-cqaado3u 10 22 exposure exposure JJ cord-334454-cqaado3u 10 23 prophylaxis prophylaxis NN cord-334454-cqaado3u 10 24 . . . cord-334454-cqaado3u 11 1 In in IN cord-334454-cqaado3u 11 2 veterinary veterinary JJ cord-334454-cqaado3u 11 3 medicine medicine NN cord-334454-cqaado3u 11 4 , , , cord-334454-cqaado3u 11 5 recombinant recombinant JJ cord-334454-cqaado3u 11 6 feline feline JJ cord-334454-cqaado3u 11 7 interferon interferon NN cord-334454-cqaado3u 11 8 omega omega NN cord-334454-cqaado3u 11 9 ( ( -LRB- cord-334454-cqaado3u 11 10 rFeIFN rfeifn NN cord-334454-cqaado3u 11 11 - - HYPH cord-334454-cqaado3u 11 12 ω ω CD cord-334454-cqaado3u 11 13 ) ) -RRB- cord-334454-cqaado3u 11 14 was be VBD cord-334454-cqaado3u 11 15 the the DT cord-334454-cqaado3u 11 16 first first JJ cord-334454-cqaado3u 11 17 interferon interferon NN cord-334454-cqaado3u 11 18 licensed license VBN cord-334454-cqaado3u 11 19 for for IN cord-334454-cqaado3u 11 20 use use NN cord-334454-cqaado3u 11 21 in in IN cord-334454-cqaado3u 11 22 cats cat NNS cord-334454-cqaado3u 11 23 . . . cord-334454-cqaado3u 12 1 Several several JJ cord-334454-cqaado3u 12 2 studies study NNS cord-334454-cqaado3u 12 3 have have VBP cord-334454-cqaado3u 12 4 recently recently RB cord-334454-cqaado3u 12 5 shown show VBN cord-334454-cqaado3u 12 6 that that IN cord-334454-cqaado3u 12 7 this this DT cord-334454-cqaado3u 12 8 compound compound NN cord-334454-cqaado3u 12 9 seems seem VBZ cord-334454-cqaado3u 12 10 to to TO cord-334454-cqaado3u 12 11 stimulate stimulate VB cord-334454-cqaado3u 12 12 the the DT cord-334454-cqaado3u 12 13 innate innate JJ cord-334454-cqaado3u 12 14 immunity immunity NN cord-334454-cqaado3u 12 15 , , , cord-334454-cqaado3u 12 16 decreasing decrease VBG cord-334454-cqaado3u 12 17 clinical clinical JJ cord-334454-cqaado3u 12 18 signs sign NNS cord-334454-cqaado3u 12 19 and and CC cord-334454-cqaado3u 12 20 co co NNS cord-334454-cqaado3u 12 21 - - NNS cord-334454-cqaado3u 12 22 infections infection NNS cord-334454-cqaado3u 12 23 in in IN cord-334454-cqaado3u 12 24 naturally naturally RB cord-334454-cqaado3u 12 25 FIV fiv NN cord-334454-cqaado3u 12 26 - - HYPH cord-334454-cqaado3u 12 27 infected infect VBN cord-334454-cqaado3u 12 28 cats cat NNS cord-334454-cqaado3u 12 29 . . . cord-334454-cqaado3u 13 1 More More JJR cord-334454-cqaado3u 13 2 than than IN cord-334454-cqaado3u 13 3 summarizing summarize VBG cord-334454-cqaado3u 13 4 the the DT cord-334454-cqaado3u 13 5 main main JJ cord-334454-cqaado3u 13 6 conclusions conclusion NNS cord-334454-cqaado3u 13 7 about about IN cord-334454-cqaado3u 13 8 rFeIFN rfeifn NN cord-334454-cqaado3u 13 9 - - HYPH cord-334454-cqaado3u 13 10 ω ω NN cord-334454-cqaado3u 13 11 in in IN cord-334454-cqaado3u 13 12 cats cat NNS cord-334454-cqaado3u 13 13 , , , cord-334454-cqaado3u 13 14 this this DT cord-334454-cqaado3u 13 15 review review NN cord-334454-cqaado3u 13 16 emphasizes emphasize VBZ cord-334454-cqaado3u 13 17 the the DT cord-334454-cqaado3u 13 18 immune immune JJ cord-334454-cqaado3u 13 19 - - HYPH cord-334454-cqaado3u 13 20 modulation modulation NN cord-334454-cqaado3u 13 21 properties property NNS cord-334454-cqaado3u 13 22 of of IN cord-334454-cqaado3u 13 23 IFN IFN NNP cord-334454-cqaado3u 13 24 therapy therapy NN cord-334454-cqaado3u 13 25 , , , cord-334454-cqaado3u 13 26 opening open VBG cord-334454-cqaado3u 13 27 new new JJ cord-334454-cqaado3u 13 28 perspectives perspective NNS cord-334454-cqaado3u 13 29 for for IN cord-334454-cqaado3u 13 30 its -PRON- PRP$ cord-334454-cqaado3u 13 31 use use NN cord-334454-cqaado3u 13 32 in in IN cord-334454-cqaado3u 13 33 retroviral retroviral JJ cord-334454-cqaado3u 13 34 infections infection NNS cord-334454-cqaado3u 13 35 . . . cord-334454-cqaado3u 14 1 Either either CC cord-334454-cqaado3u 14 2 in in IN cord-334454-cqaado3u 14 3 FIV fiv NN cord-334454-cqaado3u 14 4 - - HYPH cord-334454-cqaado3u 14 5 infected infect VBN cord-334454-cqaado3u 14 6 cats cat NNS cord-334454-cqaado3u 14 7 or or CC cord-334454-cqaado3u 14 8 in in IN cord-334454-cqaado3u 14 9 HIV HIV NNP cord-334454-cqaado3u 14 10 individuals individual NNS cord-334454-cqaado3u 14 11 , , , cord-334454-cqaado3u 14 12 type type NN cord-334454-cqaado3u 14 13 I -PRON- PRP cord-334454-cqaado3u 14 14 IFNs ifns VBP cord-334454-cqaado3u 14 15 seem seem VBP cord-334454-cqaado3u 14 16 to to TO cord-334454-cqaado3u 14 17 induce induce VB cord-334454-cqaado3u 14 18 an an DT cord-334454-cqaado3u 14 19 innate innate JJ cord-334454-cqaado3u 14 20 immune immune JJ cord-334454-cqaado3u 14 21 - - HYPH cord-334454-cqaado3u 14 22 modulation modulation NN cord-334454-cqaado3u 14 23 and and CC cord-334454-cqaado3u 14 24 should should MD cord-334454-cqaado3u 14 25 not not RB cord-334454-cqaado3u 14 26 be be VB cord-334454-cqaado3u 14 27 overlooked overlook VBN cord-334454-cqaado3u 14 28 as as IN cord-334454-cqaado3u 14 29 a a DT cord-334454-cqaado3u 14 30 therapeutic therapeutic JJ cord-334454-cqaado3u 14 31 option option NN cord-334454-cqaado3u 14 32 in in IN cord-334454-cqaado3u 14 33 retroviral retroviral JJ cord-334454-cqaado3u 14 34 infections infection NNS cord-334454-cqaado3u 14 35 . . . cord-334454-cqaado3u 15 1 In in IN cord-334454-cqaado3u 15 2 clinical clinical JJ cord-334454-cqaado3u 15 3 practice practice NN cord-334454-cqaado3u 15 4 , , , cord-334454-cqaado3u 15 5 the the DT cord-334454-cqaado3u 15 6 initial initial JJ cord-334454-cqaado3u 15 7 therapeutic therapeutic JJ cord-334454-cqaado3u 15 8 approach approach NN cord-334454-cqaado3u 15 9 in in IN cord-334454-cqaado3u 15 10 cats cat NNS cord-334454-cqaado3u 15 11 suspected suspect VBN cord-334454-cqaado3u 15 12 of of IN cord-334454-cqaado3u 15 13 retroviral retroviral JJ cord-334454-cqaado3u 15 14 infections infection NNS cord-334454-cqaado3u 15 15 is be VBZ cord-334454-cqaado3u 15 16 always always RB cord-334454-cqaado3u 15 17 supportive supportive JJ cord-334454-cqaado3u 15 18 and and CC cord-334454-cqaado3u 15 19 symptomatic symptomatic JJ cord-334454-cqaado3u 15 20 . . . cord-334454-cqaado3u 16 1 When when WRB cord-334454-cqaado3u 16 2 the the DT cord-334454-cqaado3u 16 3 diagnosis diagnosis NN cord-334454-cqaado3u 16 4 of of IN cord-334454-cqaado3u 16 5 retroviral retroviral JJ cord-334454-cqaado3u 16 6 infection infection NN cord-334454-cqaado3u 16 7 is be VBZ cord-334454-cqaado3u 16 8 established establish VBN cord-334454-cqaado3u 16 9 , , , cord-334454-cqaado3u 16 10 antivirals antiviral NNS cord-334454-cqaado3u 16 11 and and CC cord-334454-cqaado3u 16 12 immune immune JJ cord-334454-cqaado3u 16 13 modulators modulator NNS cord-334454-cqaado3u 16 14 can can MD cord-334454-cqaado3u 16 15 be be VB cord-334454-cqaado3u 16 16 considered consider VBN cord-334454-cqaado3u 16 17 on on IN cord-334454-cqaado3u 16 18 short short JJ cord-334454-cqaado3u 16 19 - - HYPH cord-334454-cqaado3u 16 20 and and CC cord-334454-cqaado3u 16 21 long long JJ cord-334454-cqaado3u 16 22 - - HYPH cord-334454-cqaado3u 16 23 term term NN cord-334454-cqaado3u 16 24 management management NN cord-334454-cqaado3u 16 25 . . . cord-334454-cqaado3u 17 1 Taking take VBG cord-334454-cqaado3u 17 2 into into IN cord-334454-cqaado3u 17 3 account account NN cord-334454-cqaado3u 17 4 that that IN cord-334454-cqaado3u 17 5 most most JJS cord-334454-cqaado3u 17 6 of of IN cord-334454-cqaado3u 17 7 these these DT cord-334454-cqaado3u 17 8 drugs drug NNS cord-334454-cqaado3u 17 9 are be VBP cord-334454-cqaado3u 17 10 licensed license VBN cord-334454-cqaado3u 17 11 for for IN cord-334454-cqaado3u 17 12 use use NN cord-334454-cqaado3u 17 13 in in IN cord-334454-cqaado3u 17 14 humans human NNS cord-334454-cqaado3u 17 15 , , , cord-334454-cqaado3u 17 16 there there EX cord-334454-cqaado3u 17 17 is be VBZ cord-334454-cqaado3u 17 18 a a DT cord-334454-cqaado3u 17 19 lack lack NN cord-334454-cqaado3u 17 20 of of IN cord-334454-cqaado3u 17 21 well well RB cord-334454-cqaado3u 17 22 - - HYPH cord-334454-cqaado3u 17 23 controlled control VBN cord-334454-cqaado3u 17 24 clinical clinical JJ cord-334454-cqaado3u 17 25 trials trial NNS cord-334454-cqaado3u 17 26 in in IN cord-334454-cqaado3u 17 27 cats cat NNS cord-334454-cqaado3u 17 28 and and CC cord-334454-cqaado3u 17 29 their -PRON- PRP$ cord-334454-cqaado3u 17 30 efficacy efficacy NN cord-334454-cqaado3u 17 31 is be VBZ cord-334454-cqaado3u 17 32 not not RB cord-334454-cqaado3u 17 33 entirely entirely RB cord-334454-cqaado3u 17 34 clear clear JJ cord-334454-cqaado3u 17 35 [ [ -LRB- cord-334454-cqaado3u 17 36 1 1 CD cord-334454-cqaado3u 17 37 , , , cord-334454-cqaado3u 17 38 2 2 CD cord-334454-cqaado3u 17 39 ] ] -RRB- cord-334454-cqaado3u 17 40 . . . cord-334454-cqaado3u 18 1 Nowadays nowadays RB cord-334454-cqaado3u 18 2 , , , cord-334454-cqaado3u 18 3 there there EX cord-334454-cqaado3u 18 4 are be VBP cord-334454-cqaado3u 18 5 no no DT cord-334454-cqaado3u 18 6 antivirals antiviral NNS cord-334454-cqaado3u 18 7 licensed license VBN cord-334454-cqaado3u 18 8 for for IN cord-334454-cqaado3u 18 9 use use NN cord-334454-cqaado3u 18 10 in in IN cord-334454-cqaado3u 18 11 veterinary veterinary JJ cord-334454-cqaado3u 18 12 medicine medicine NN cord-334454-cqaado3u 18 13 with with IN cord-334454-cqaado3u 18 14 the the DT cord-334454-cqaado3u 18 15 exception exception NN cord-334454-cqaado3u 18 16 of of IN cord-334454-cqaado3u 18 17 several several JJ cord-334454-cqaado3u 18 18 immune immune JJ cord-334454-cqaado3u 18 19 modulators modulator NNS cord-334454-cqaado3u 18 20 , , , cord-334454-cqaado3u 18 21 which which WDT cord-334454-cqaado3u 18 22 have have VBP cord-334454-cqaado3u 18 23 concurrent concurrent JJ cord-334454-cqaado3u 18 24 antiviral antiviral JJ cord-334454-cqaado3u 18 25 properties property NNS cord-334454-cqaado3u 18 26 . . . cord-334454-cqaado3u 19 1 Therefore therefore RB cord-334454-cqaado3u 19 2 , , , cord-334454-cqaado3u 19 3 all all PDT cord-334454-cqaado3u 19 4 the the DT cord-334454-cqaado3u 19 5 truly truly RB cord-334454-cqaado3u 19 6 antiviral antiviral JJ cord-334454-cqaado3u 19 7 compounds compound NNS cord-334454-cqaado3u 19 8 used use VBN cord-334454-cqaado3u 19 9 in in IN cord-334454-cqaado3u 19 10 dogs dog NNS cord-334454-cqaado3u 19 11 and and CC cord-334454-cqaado3u 19 12 cats cat NNS cord-334454-cqaado3u 19 13 are be VBP cord-334454-cqaado3u 19 14 those those DT cord-334454-cqaado3u 19 15 licensed license VBN cord-334454-cqaado3u 19 16 for for IN cord-334454-cqaado3u 19 17 use use NN cord-334454-cqaado3u 19 18 in in IN cord-334454-cqaado3u 19 19 humans human NNS cord-334454-cqaado3u 19 20 , , , cord-334454-cqaado3u 19 21 namely namely RB cord-334454-cqaado3u 19 22 in in IN cord-334454-cqaado3u 19 23 HIV HIV NNP cord-334454-cqaado3u 19 24 therapies therapy NNS cord-334454-cqaado3u 19 25 [ [ -LRB- cord-334454-cqaado3u 19 26 1 1 CD cord-334454-cqaado3u 19 27 ] ] -RRB- cord-334454-cqaado3u 19 28 [ [ -LRB- cord-334454-cqaado3u 19 29 2 2 CD cord-334454-cqaado3u 19 30 ] ] -RRB- cord-334454-cqaado3u 19 31 [ [ -LRB- cord-334454-cqaado3u 19 32 3 3 CD cord-334454-cqaado3u 19 33 ] ] -RRB- cord-334454-cqaado3u 19 34 . . . cord-334454-cqaado3u 20 1 On on IN cord-334454-cqaado3u 20 2 the the DT cord-334454-cqaado3u 20 3 other other JJ cord-334454-cqaado3u 20 4 hand hand NN cord-334454-cqaado3u 20 5 , , , cord-334454-cqaado3u 20 6 interestingly interestingly RB cord-334454-cqaado3u 20 7 , , , cord-334454-cqaado3u 20 8 the the DT cord-334454-cqaado3u 20 9 administration administration NN cord-334454-cqaado3u 20 10 of of IN cord-334454-cqaado3u 20 11 antivirals antiviral NNS cord-334454-cqaado3u 20 12 in in IN cord-334454-cqaado3u 20 13 cats cat NNS cord-334454-cqaado3u 20 14 has have VBZ cord-334454-cqaado3u 20 15 been be VBN cord-334454-cqaado3u 20 16 frequently frequently RB cord-334454-cqaado3u 20 17 documented document VBN cord-334454-cqaado3u 20 18 due due IN cord-334454-cqaado3u 20 19 to to IN cord-334454-cqaado3u 20 20 the the DT cord-334454-cqaado3u 20 21 fact fact NN cord-334454-cqaado3u 20 22 that that IN cord-334454-cqaado3u 20 23 FIV fiv NN cord-334454-cqaado3u 20 24 - - HYPH cord-334454-cqaado3u 20 25 infected infect VBN cord-334454-cqaado3u 20 26 cats cat NNS cord-334454-cqaado3u 20 27 are be VBP cord-334454-cqaado3u 20 28 commonly commonly RB cord-334454-cqaado3u 20 29 used use VBN cord-334454-cqaado3u 20 30 as as IN cord-334454-cqaado3u 20 31 HIV HIV NNP cord-334454-cqaado3u 20 32 experimental experimental JJ cord-334454-cqaado3u 20 33 models model NNS cord-334454-cqaado3u 20 34 . . . cord-334454-cqaado3u 21 1 Even even RB cord-334454-cqaado3u 21 2 if if IN cord-334454-cqaado3u 21 3 antivirals antiviral NNS cord-334454-cqaado3u 21 4 have have VBP cord-334454-cqaado3u 21 5 shown show VBN cord-334454-cqaado3u 21 6 a a DT cord-334454-cqaado3u 21 7 low low JJ cord-334454-cqaado3u 21 8 efficacy efficacy NN cord-334454-cqaado3u 21 9 in in IN cord-334454-cqaado3u 21 10 cats cat NNS cord-334454-cqaado3u 21 11 and and CC cord-334454-cqaado3u 21 12 can can MD cord-334454-cqaado3u 21 13 induce induce VB cord-334454-cqaado3u 21 14 significant significant JJ cord-334454-cqaado3u 21 15 toxic toxic JJ cord-334454-cqaado3u 21 16 effects effect NNS cord-334454-cqaado3u 21 17 , , , cord-334454-cqaado3u 21 18 several several JJ cord-334454-cqaado3u 21 19 of of IN cord-334454-cqaado3u 21 20 them -PRON- PRP cord-334454-cqaado3u 21 21 are be VBP cord-334454-cqaado3u 21 22 used use VBN cord-334454-cqaado3u 21 23 on on IN cord-334454-cqaado3u 21 24 the the DT cord-334454-cqaado3u 21 25 management management NN cord-334454-cqaado3u 21 26 of of IN cord-334454-cqaado3u 21 27 retroviral retroviral JJ cord-334454-cqaado3u 21 28 infections infection NNS cord-334454-cqaado3u 21 29 [ [ -LRB- cord-334454-cqaado3u 21 30 1 1 CD cord-334454-cqaado3u 21 31 , , , cord-334454-cqaado3u 21 32 2 2 CD cord-334454-cqaado3u 21 33 , , , cord-334454-cqaado3u 21 34 4 4 CD cord-334454-cqaado3u 21 35 ] ] -RRB- cord-334454-cqaado3u 21 36 . . . cord-334454-cqaado3u 22 1 Among among IN cord-334454-cqaado3u 22 2 them -PRON- PRP cord-334454-cqaado3u 22 3 , , , cord-334454-cqaado3u 22 4 the the DT cord-334454-cqaado3u 22 5 RT RT NNP cord-334454-cqaado3u 22 6 inhibitors inhibitor NNS cord-334454-cqaado3u 22 7 / / SYM cord-334454-cqaado3u 22 8 nucleoside nucleoside JJ cord-334454-cqaado3u 22 9 analogues analogue NNS cord-334454-cqaado3u 22 10 are be VBP cord-334454-cqaado3u 22 11 the the DT cord-334454-cqaado3u 22 12 most most RBS cord-334454-cqaado3u 22 13 common common JJ cord-334454-cqaado3u 22 14 . . . cord-334454-cqaado3u 23 1 The the DT cord-334454-cqaado3u 23 2 majority majority NN cord-334454-cqaado3u 23 3 are be VBP cord-334454-cqaado3u 23 4 nucleoside nucleoside JJ cord-334454-cqaado3u 23 5 analogues analogue NNS cord-334454-cqaado3u 23 6 which which WDT cord-334454-cqaado3u 23 7 , , , cord-334454-cqaado3u 23 8 acting act VBG cord-334454-cqaado3u 23 9 as as IN cord-334454-cqaado3u 23 10 anti anti JJ cord-334454-cqaado3u 23 11 - - NNS cord-334454-cqaado3u 23 12 metabolites metabolite NNS cord-334454-cqaado3u 23 13 , , , cord-334454-cqaado3u 23 14 are be VBP cord-334454-cqaado3u 23 15 " " `` cord-334454-cqaado3u 23 16 false false JJ cord-334454-cqaado3u 23 17 substrates substrate NNS cord-334454-cqaado3u 23 18 " " '' cord-334454-cqaado3u 23 19 that that WDT cord-334454-cqaado3u 23 20 bind bind VBP cord-334454-cqaado3u 23 21 to to IN cord-334454-cqaado3u 23 22 RT RT NNP cord-334454-cqaado3u 23 23 enzyme enzyme NN cord-334454-cqaado3u 23 24 and and CC cord-334454-cqaado3u 23 25 block block VB cord-334454-cqaado3u 23 26 its -PRON- PRP$ cord-334454-cqaado3u 23 27 activity activity NN cord-334454-cqaado3u 23 28 [ [ -LRB- cord-334454-cqaado3u 23 29 4 4 CD cord-334454-cqaado3u 23 30 ] ] -RRB- cord-334454-cqaado3u 23 31 . . . cord-334454-cqaado3u 24 1 Other other JJ cord-334454-cqaado3u 24 2 antivirals antiviral NNS cord-334454-cqaado3u 24 3 that that WDT cord-334454-cqaado3u 24 4 can can MD cord-334454-cqaado3u 24 5 be be VB cord-334454-cqaado3u 24 6 used use VBN cord-334454-cqaado3u 24 7 in in IN cord-334454-cqaado3u 24 8 retroviral retroviral JJ cord-334454-cqaado3u 24 9 infections infection NNS cord-334454-cqaado3u 24 10 are be VBP cord-334454-cqaado3u 24 11 antagonists antagonist NNS cord-334454-cqaado3u 24 12 / / , cord-334454-cqaado3u 24 13 homologous homologous JJ cord-334454-cqaado3u 24 14 of of IN cord-334454-cqaado3u 24 15 receptors receptor NNS cord-334454-cqaado3u 24 16 , , , cord-334454-cqaado3u 24 17 namely namely RB cord-334454-cqaado3u 24 18 byciclams byciclams NNP cord-334454-cqaado3u 24 19 such such JJ cord-334454-cqaado3u 24 20 as as IN cord-334454-cqaado3u 24 21 plerixafor plerixafor NN cord-334454-cqaado3u 24 22 and and CC cord-334454-cqaado3u 24 23 AMD AMD NNP cord-334454-cqaado3u 24 24 3100 3100 CD cord-334454-cqaado3u 24 25 , , , cord-334454-cqaado3u 24 26 which which WDT cord-334454-cqaado3u 24 27 bind bind VBP cord-334454-cqaado3u 24 28 either either DT cord-334454-cqaado3u 24 29 to to IN cord-334454-cqaado3u 24 30 viruses virus NNS cord-334454-cqaado3u 24 31 ( ( -LRB- cord-334454-cqaado3u 24 32 homologous homologous JJ cord-334454-cqaado3u 24 33 ) ) -RRB- cord-334454-cqaado3u 24 34 or or CC cord-334454-cqaado3u 24 35 to to IN cord-334454-cqaado3u 24 36 cell cell NN cord-334454-cqaado3u 24 37 - - HYPH cord-334454-cqaado3u 24 38 receptors receptor NNS cord-334454-cqaado3u 24 39 ( ( -LRB- cord-334454-cqaado3u 24 40 antagonists antagonist NNS cord-334454-cqaado3u 24 41 ) ) -RRB- cord-334454-cqaado3u 24 42 , , , cord-334454-cqaado3u 24 43 inhibiting inhibit VBG cord-334454-cqaado3u 24 44 the the DT cord-334454-cqaado3u 24 45 virus virus NN cord-334454-cqaado3u 24 46 - - HYPH cord-334454-cqaado3u 24 47 cell cell NN cord-334454-cqaado3u 24 48 interaction interaction NN cord-334454-cqaado3u 24 49 . . . cord-334454-cqaado3u 25 1 With with IN cord-334454-cqaado3u 25 2 the the DT cord-334454-cqaado3u 25 3 exception exception NN cord-334454-cqaado3u 25 4 of of IN cord-334454-cqaado3u 25 5 several several JJ cord-334454-cqaado3u 25 6 drugs drug NNS cord-334454-cqaado3u 25 7 , , , cord-334454-cqaado3u 25 8 these these DT cord-334454-cqaado3u 25 9 compounds compound NNS cord-334454-cqaado3u 25 10 are be VBP cord-334454-cqaado3u 25 11 strongly strongly RB cord-334454-cqaado3u 25 12 selective selective JJ cord-334454-cqaado3u 25 13 for for IN cord-334454-cqaado3u 25 14 HIV HIV NNP cord-334454-cqaado3u 25 15 , , , cord-334454-cqaado3u 25 16 meaning mean VBG cord-334454-cqaado3u 25 17 that that IN cord-334454-cqaado3u 25 18 they -PRON- PRP cord-334454-cqaado3u 25 19 are be VBP cord-334454-cqaado3u 25 20 not not RB cord-334454-cqaado3u 25 21 used use VBN cord-334454-cqaado3u 25 22 in in IN cord-334454-cqaado3u 25 23 veterinary veterinary JJ cord-334454-cqaado3u 25 24 medicine medicine NN cord-334454-cqaado3u 25 25 [ [ -LRB- cord-334454-cqaado3u 25 26 4 4 CD cord-334454-cqaado3u 25 27 ] ] -RRB- cord-334454-cqaado3u 25 28 . . . cord-334454-cqaado3u 26 1 Taking take VBG cord-334454-cqaado3u 26 2 part part NN cord-334454-cqaado3u 26 3 in in IN cord-334454-cqaado3u 26 4 the the DT cord-334454-cqaado3u 26 5 group group NN cord-334454-cqaado3u 26 6 of of IN cord-334454-cqaado3u 26 7 " " `` cord-334454-cqaado3u 26 8 immune immune JJ cord-334454-cqaado3u 26 9 therapy therapy NN cord-334454-cqaado3u 26 10 " " '' cord-334454-cqaado3u 26 11 , , , cord-334454-cqaado3u 26 12 by by IN cord-334454-cqaado3u 26 13 definition definition NN cord-334454-cqaado3u 26 14 , , , cord-334454-cqaado3u 26 15 immune immune JJ cord-334454-cqaado3u 26 16 modulators modulator NNS cord-334454-cqaado3u 26 17 are be VBP cord-334454-cqaado3u 26 18 compounds compound NNS cord-334454-cqaado3u 26 19 that that WDT cord-334454-cqaado3u 26 20 interfere interfere VBP cord-334454-cqaado3u 26 21 with with IN cord-334454-cqaado3u 26 22 the the DT cord-334454-cqaado3u 26 23 immune immune JJ cord-334454-cqaado3u 26 24 system system NN cord-334454-cqaado3u 26 25 . . . cord-334454-cqaado3u 27 1 They -PRON- PRP cord-334454-cqaado3u 27 2 are be VBP cord-334454-cqaado3u 27 3 commonly commonly RB cord-334454-cqaado3u 27 4 used use VBN cord-334454-cqaado3u 27 5 in in IN cord-334454-cqaado3u 27 6 different different JJ cord-334454-cqaado3u 27 7 clinical clinical JJ cord-334454-cqaado3u 27 8 situations situation NNS cord-334454-cqaado3u 27 9 , , , cord-334454-cqaado3u 27 10 particularly particularly RB cord-334454-cqaado3u 27 11 in in IN cord-334454-cqaado3u 27 12 canine canine JJ cord-334454-cqaado3u 27 13 and and CC cord-334454-cqaado3u 27 14 feline feline JJ cord-334454-cqaado3u 27 15 viral viral JJ cord-334454-cqaado3u 27 16 infections infection NNS cord-334454-cqaado3u 27 17 . . . cord-334454-cqaado3u 28 1 It -PRON- PRP cord-334454-cqaado3u 28 2 is be VBZ cord-334454-cqaado3u 28 3 believed believe VBN cord-334454-cqaado3u 28 4 that that IN cord-334454-cqaado3u 28 5 immune immune JJ cord-334454-cqaado3u 28 6 modulators modulator NNS cord-334454-cqaado3u 28 7 restore restore VBP cord-334454-cqaado3u 28 8 several several JJ cord-334454-cqaado3u 28 9 functions function NNS cord-334454-cqaado3u 28 10 of of IN cord-334454-cqaado3u 28 11 the the DT cord-334454-cqaado3u 28 12 immune immune JJ cord-334454-cqaado3u 28 13 system system NN cord-334454-cqaado3u 28 14 , , , cord-334454-cqaado3u 28 15 allowing allow VBG cord-334454-cqaado3u 28 16 a a DT cord-334454-cqaado3u 28 17 better well JJR cord-334454-cqaado3u 28 18 management management NN cord-334454-cqaado3u 28 19 of of IN cord-334454-cqaado3u 28 20 opportunistic opportunistic JJ cord-334454-cqaado3u 28 21 infections infection NNS cord-334454-cqaado3u 28 22 and and CC cord-334454-cqaado3u 28 23 a a DT cord-334454-cqaado3u 28 24 better well JJR cord-334454-cqaado3u 28 25 clinical clinical JJ cord-334454-cqaado3u 28 26 recovery recovery NN cord-334454-cqaado3u 28 27 . . . cord-334454-cqaado3u 29 1 Some some DT cord-334454-cqaado3u 29 2 of of IN cord-334454-cqaado3u 29 3 these these DT cord-334454-cqaado3u 29 4 compounds compound NNS cord-334454-cqaado3u 29 5 can can MD cord-334454-cqaado3u 29 6 even even RB cord-334454-cqaado3u 29 7 have have VB cord-334454-cqaado3u 29 8 a a DT cord-334454-cqaado3u 29 9 direct direct JJ cord-334454-cqaado3u 29 10 antiviral antiviral JJ cord-334454-cqaado3u 29 11 effect effect NN cord-334454-cqaado3u 29 12 [ [ -LRB- cord-334454-cqaado3u 29 13 4 4 CD cord-334454-cqaado3u 29 14 ] ] -RRB- cord-334454-cqaado3u 29 15 . . . cord-334454-cqaado3u 30 1 In in IN cord-334454-cqaado3u 30 2 between between IN cord-334454-cqaado3u 30 3 the the DT cord-334454-cqaado3u 30 4 well well RB cord-334454-cqaado3u 30 5 - - HYPH cord-334454-cqaado3u 30 6 known know VBN cord-334454-cqaado3u 30 7 immune immune JJ cord-334454-cqaado3u 30 8 modulators modulator NNS cord-334454-cqaado3u 30 9 , , , cord-334454-cqaado3u 30 10 interferons interferon NNS cord-334454-cqaado3u 30 11 ( ( -LRB- cord-334454-cqaado3u 30 12 IFNs IFNs NNP cord-334454-cqaado3u 30 13 ) ) -RRB- cord-334454-cqaado3u 30 14 will will MD cord-334454-cqaado3u 30 15 be be VB cord-334454-cqaado3u 30 16 further further RB cord-334454-cqaado3u 30 17 discussed discuss VBN cord-334454-cqaado3u 30 18 , , , cord-334454-cqaado3u 30 19 mainly mainly RB cord-334454-cqaado3u 30 20 due due IN cord-334454-cqaado3u 30 21 to to IN cord-334454-cqaado3u 30 22 its -PRON- PRP$ cord-334454-cqaado3u 30 23 current current JJ cord-334454-cqaado3u 30 24 use use NN cord-334454-cqaado3u 30 25 in in IN cord-334454-cqaado3u 30 26 retroviral retroviral JJ cord-334454-cqaado3u 30 27 infections infection NNS cord-334454-cqaado3u 30 28 . . . cord-334454-cqaado3u 31 1 Interferons interferon NNS cord-334454-cqaado3u 31 2 ( ( -LRB- cord-334454-cqaado3u 31 3 IFNs ifn NNS cord-334454-cqaado3u 31 4 ) ) -RRB- cord-334454-cqaado3u 31 5 are be VBP cord-334454-cqaado3u 31 6 key key JJ cord-334454-cqaado3u 31 7 components component NNS cord-334454-cqaado3u 31 8 of of IN cord-334454-cqaado3u 31 9 the the DT cord-334454-cqaado3u 31 10 host host NN cord-334454-cqaado3u 31 11 immune immune JJ cord-334454-cqaado3u 31 12 system system NN cord-334454-cqaado3u 31 13 , , , cord-334454-cqaado3u 31 14 being be VBG cord-334454-cqaado3u 31 15 particularly particularly RB cord-334454-cqaado3u 31 16 relevant relevant JJ cord-334454-cqaado3u 31 17 in in IN cord-334454-cqaado3u 31 18 viral viral JJ cord-334454-cqaado3u 31 19 infections infection NNS cord-334454-cqaado3u 31 20 [ [ -LRB- cord-334454-cqaado3u 31 21 5 5 CD cord-334454-cqaado3u 31 22 ] ] -RRB- cord-334454-cqaado3u 31 23 . . . cord-334454-cqaado3u 32 1 The the DT cord-334454-cqaado3u 32 2 large large JJ cord-334454-cqaado3u 32 3 family family NN cord-334454-cqaado3u 32 4 of of IN cord-334454-cqaado3u 32 5 IFNs ifn NNS cord-334454-cqaado3u 32 6 can can MD cord-334454-cqaado3u 32 7 be be VB cord-334454-cqaado3u 32 8 divided divide VBN cord-334454-cqaado3u 32 9 into into IN cord-334454-cqaado3u 32 10 different different JJ cord-334454-cqaado3u 32 11 types type NNS cord-334454-cqaado3u 32 12 . . . cord-334454-cqaado3u 33 1 Type type NN cord-334454-cqaado3u 33 2 I -PRON- PRP cord-334454-cqaado3u 33 3 IFNs ifn NNS cord-334454-cqaado3u 33 4 are be VBP cord-334454-cqaado3u 33 5 the the DT cord-334454-cqaado3u 33 6 most most RBS cord-334454-cqaado3u 33 7 studied study VBN cord-334454-cqaado3u 33 8 ones one NNS cord-334454-cqaado3u 33 9 as as IN cord-334454-cqaado3u 33 10 they -PRON- PRP cord-334454-cqaado3u 33 11 are be VBP cord-334454-cqaado3u 33 12 commonly commonly RB cord-334454-cqaado3u 33 13 used use VBN cord-334454-cqaado3u 33 14 for for IN cord-334454-cqaado3u 33 15 therapeutic therapeutic JJ cord-334454-cqaado3u 33 16 purposes purpose NNS cord-334454-cqaado3u 33 17 . . . cord-334454-cqaado3u 34 1 Among among IN cord-334454-cqaado3u 34 2 their -PRON- PRP$ cord-334454-cqaado3u 34 3 major major JJ cord-334454-cqaado3u 34 4 functions function NNS cord-334454-cqaado3u 34 5 , , , cord-334454-cqaado3u 34 6 type type NN cord-334454-cqaado3u 34 7 I -PRON- PRP cord-334454-cqaado3u 34 8 IFNs ifns VBP cord-334454-cqaado3u 34 9 increase increase NN cord-334454-cqaado3u 34 10 and and CC cord-334454-cqaado3u 34 11 sensitize sensitize VB cord-334454-cqaado3u 34 12 the the DT cord-334454-cqaado3u 34 13 immune immune JJ cord-334454-cqaado3u 34 14 system system NN cord-334454-cqaado3u 34 15 towards towards IN cord-334454-cqaado3u 34 16 the the DT cord-334454-cqaado3u 34 17 microbial microbial JJ cord-334454-cqaado3u 34 18 recognition recognition NN cord-334454-cqaado3u 34 19 [ [ -LRB- cord-334454-cqaado3u 34 20 6 6 CD cord-334454-cqaado3u 34 21 ] ] -RRB- cord-334454-cqaado3u 34 22 , , , cord-334454-cqaado3u 34 23 establishing establish VBG cord-334454-cqaado3u 34 24 an an DT cord-334454-cqaado3u 34 25 important important JJ cord-334454-cqaado3u 34 26 link link NN cord-334454-cqaado3u 34 27 between between IN cord-334454-cqaado3u 34 28 innate innate NN cord-334454-cqaado3u 34 29 and and CC cord-334454-cqaado3u 34 30 acquired acquire VBN cord-334454-cqaado3u 34 31 immunity immunity NN cord-334454-cqaado3u 34 32 [ [ -LRB- cord-334454-cqaado3u 34 33 7 7 CD cord-334454-cqaado3u 34 34 ] ] -RRB- cord-334454-cqaado3u 34 35 . . . cord-334454-cqaado3u 35 1 Furthermore furthermore RB cord-334454-cqaado3u 35 2 , , , cord-334454-cqaado3u 35 3 they -PRON- PRP cord-334454-cqaado3u 35 4 have have VBP cord-334454-cqaado3u 35 5 different different JJ cord-334454-cqaado3u 35 6 anti anti JJ cord-334454-cqaado3u 35 7 - - JJ cord-334454-cqaado3u 35 8 viral viral JJ cord-334454-cqaado3u 35 9 properties property NNS cord-334454-cqaado3u 35 10 , , , cord-334454-cqaado3u 35 11 blocking block VBG cord-334454-cqaado3u 35 12 viral viral JJ cord-334454-cqaado3u 35 13 replication replication NN cord-334454-cqaado3u 35 14 and and CC cord-334454-cqaado3u 35 15 inducing induce VBG cord-334454-cqaado3u 35 16 apoptosis apoptosis NN cord-334454-cqaado3u 35 17 of of IN cord-334454-cqaado3u 35 18 infected infected JJ cord-334454-cqaado3u 35 19 cells cell NNS cord-334454-cqaado3u 35 20 [ [ -LRB- cord-334454-cqaado3u 35 21 8 8 CD cord-334454-cqaado3u 35 22 ] ] -RRB- cord-334454-cqaado3u 35 23 [ [ -LRB- cord-334454-cqaado3u 35 24 9 9 CD cord-334454-cqaado3u 35 25 ] ] -RRB- cord-334454-cqaado3u 35 26 [ [ -LRB- cord-334454-cqaado3u 35 27 10 10 CD cord-334454-cqaado3u 35 28 ] ] -RRB- cord-334454-cqaado3u 35 29 [ [ -LRB- cord-334454-cqaado3u 35 30 11 11 CD cord-334454-cqaado3u 35 31 ] ] -RRB- cord-334454-cqaado3u 35 32 . . . cord-334454-cqaado3u 36 1 In in IN cord-334454-cqaado3u 36 2 human human JJ cord-334454-cqaado3u 36 3 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 36 4 virus virus NN cord-334454-cqaado3u 36 5 ( ( -LRB- cord-334454-cqaado3u 36 6 HIV HIV NNP cord-334454-cqaado3u 36 7 ) ) -RRB- cord-334454-cqaado3u 36 8 , , , cord-334454-cqaado3u 36 9 the the DT cord-334454-cqaado3u 36 10 therapeutic therapeutic JJ cord-334454-cqaado3u 36 11 use use NN cord-334454-cqaado3u 36 12 of of IN cord-334454-cqaado3u 36 13 IFNs ifn NNS cord-334454-cqaado3u 36 14 has have VBZ cord-334454-cqaado3u 36 15 been be VBN cord-334454-cqaado3u 36 16 assessed assess VBN cord-334454-cqaado3u 36 17 in in IN cord-334454-cqaado3u 36 18 various various JJ cord-334454-cqaado3u 36 19 in in IN cord-334454-cqaado3u 36 20 vitro vitro FW cord-334454-cqaado3u 36 21 and and CC cord-334454-cqaado3u 36 22 in in IN cord-334454-cqaado3u 36 23 vivo vivo NNP cord-334454-cqaado3u 36 24 studies study NNS cord-334454-cqaado3u 36 25 . . . cord-334454-cqaado3u 37 1 In in IN cord-334454-cqaado3u 37 2 vitro vitro FW cord-334454-cqaado3u 37 3 , , , cord-334454-cqaado3u 37 4 it -PRON- PRP cord-334454-cqaado3u 37 5 was be VBD cord-334454-cqaado3u 37 6 proven prove VBN cord-334454-cqaado3u 37 7 that that IN cord-334454-cqaado3u 37 8 IFNs ifn NNS cord-334454-cqaado3u 37 9 are be VBP cord-334454-cqaado3u 37 10 able able JJ cord-334454-cqaado3u 37 11 to to TO cord-334454-cqaado3u 37 12 restrict restrict VB cord-334454-cqaado3u 37 13 HIV HIV NNP cord-334454-cqaado3u 37 14 replication replication NN cord-334454-cqaado3u 37 15 inducing induce VBG cord-334454-cqaado3u 37 16 an an DT cord-334454-cqaado3u 37 17 antiviral antiviral JJ cord-334454-cqaado3u 37 18 state state NN cord-334454-cqaado3u 37 19 and and CC cord-334454-cqaado3u 37 20 preventing prevent VBG cord-334454-cqaado3u 37 21 viral viral JJ cord-334454-cqaado3u 37 22 infection infection NN cord-334454-cqaado3u 37 23 [ [ -LRB- cord-334454-cqaado3u 37 24 12 12 CD cord-334454-cqaado3u 37 25 , , , cord-334454-cqaado3u 37 26 13 13 CD cord-334454-cqaado3u 37 27 ] ] -RRB- cord-334454-cqaado3u 37 28 . . . cord-334454-cqaado3u 38 1 In in IN cord-334454-cqaado3u 38 2 vivo vivo NN cord-334454-cqaado3u 38 3 , , , cord-334454-cqaado3u 38 4 despite despite IN cord-334454-cqaado3u 38 5 the the DT cord-334454-cqaado3u 38 6 HIV HIV NNP cord-334454-cqaado3u 38 7 's 's POS cord-334454-cqaado3u 38 8 evasion evasion NN cord-334454-cqaado3u 38 9 mechanisms mechanism NNS cord-334454-cqaado3u 38 10 , , , cord-334454-cqaado3u 38 11 IFNs ifn NNS cord-334454-cqaado3u 38 12 seem seem VBP cord-334454-cqaado3u 38 13 to to TO cord-334454-cqaado3u 38 14 play play VB cord-334454-cqaado3u 38 15 an an DT cord-334454-cqaado3u 38 16 important important JJ cord-334454-cqaado3u 38 17 protective protective JJ cord-334454-cqaado3u 38 18 role role NN cord-334454-cqaado3u 38 19 against against IN cord-334454-cqaado3u 38 20 HIV HIV NNP cord-334454-cqaado3u 38 21 infection infection NN cord-334454-cqaado3u 38 22 in in IN cord-334454-cqaado3u 38 23 seronegative seronegative JJ cord-334454-cqaado3u 38 24 individuals individual NNS cord-334454-cqaado3u 38 25 exposed expose VBN cord-334454-cqaado3u 38 26 to to IN cord-334454-cqaado3u 38 27 the the DT cord-334454-cqaado3u 38 28 virus virus NN cord-334454-cqaado3u 38 29 [ [ -LRB- cord-334454-cqaado3u 38 30 14 14 CD cord-334454-cqaado3u 38 31 , , , cord-334454-cqaado3u 38 32 15 15 CD cord-334454-cqaado3u 38 33 ] ] -RRB- cord-334454-cqaado3u 38 34 . . . cord-334454-cqaado3u 39 1 Moreover moreover RB cord-334454-cqaado3u 39 2 , , , cord-334454-cqaado3u 39 3 its -PRON- PRP$ cord-334454-cqaado3u 39 4 therapeutic therapeutic JJ cord-334454-cqaado3u 39 5 administration administration NN cord-334454-cqaado3u 39 6 showed show VBD cord-334454-cqaado3u 39 7 a a DT cord-334454-cqaado3u 39 8 durable durable JJ cord-334454-cqaado3u 39 9 suppression suppression NN cord-334454-cqaado3u 39 10 of of IN cord-334454-cqaado3u 39 11 viral viral JJ cord-334454-cqaado3u 39 12 replication replication NN cord-334454-cqaado3u 39 13 and and CC cord-334454-cqaado3u 39 14 decreased decrease VBD cord-334454-cqaado3u 39 15 viral viral JJ cord-334454-cqaado3u 39 16 integration integration NN cord-334454-cqaado3u 39 17 following follow VBG cord-334454-cqaado3u 39 18 anti anti JJ cord-334454-cqaado3u 39 19 - - JJ cord-334454-cqaado3u 39 20 retroviral retroviral JJ cord-334454-cqaado3u 39 21 therapy therapy NN cord-334454-cqaado3u 39 22 in in IN cord-334454-cqaado3u 39 23 HIV HIV NNP cord-334454-cqaado3u 39 24 individuals individual NNS cord-334454-cqaado3u 39 25 [ [ -LRB- cord-334454-cqaado3u 39 26 16 16 CD cord-334454-cqaado3u 39 27 ] ] -RRB- cord-334454-cqaado3u 39 28 . . . cord-334454-cqaado3u 40 1 Even even RB cord-334454-cqaado3u 40 2 if if IN cord-334454-cqaado3u 40 3 further further JJ cord-334454-cqaado3u 40 4 studies study NNS cord-334454-cqaado3u 40 5 are be VBP cord-334454-cqaado3u 40 6 needed need VBN cord-334454-cqaado3u 40 7 to to TO cord-334454-cqaado3u 40 8 investigate investigate VB cord-334454-cqaado3u 40 9 the the DT cord-334454-cqaado3u 40 10 therapeutic therapeutic JJ cord-334454-cqaado3u 40 11 effects effect NNS cord-334454-cqaado3u 40 12 of of IN cord-334454-cqaado3u 40 13 IFN IFN NNP cord-334454-cqaado3u 40 14 in in IN cord-334454-cqaado3u 40 15 HIV HIV NNP cord-334454-cqaado3u 40 16 , , , cord-334454-cqaado3u 40 17 its -PRON- PRP$ cord-334454-cqaado3u 40 18 protective protective JJ cord-334454-cqaado3u 40 19 role role NN cord-334454-cqaado3u 40 20 on on IN cord-334454-cqaado3u 40 21 the the DT cord-334454-cqaado3u 40 22 early early JJ cord-334454-cqaado3u 40 23 stages stage NNS cord-334454-cqaado3u 40 24 of of IN cord-334454-cqaado3u 40 25 infection infection NN cord-334454-cqaado3u 40 26 aims aim VBZ cord-334454-cqaado3u 40 27 to to TO cord-334454-cqaado3u 40 28 consider consider VB cord-334454-cqaado3u 40 29 that that IN cord-334454-cqaado3u 40 30 IFN IFN NNP cord-334454-cqaado3u 40 31 therapy therapy NN cord-334454-cqaado3u 40 32 seems seem VBZ cord-334454-cqaado3u 40 33 particularly particularly RB cord-334454-cqaado3u 40 34 useful useful JJ cord-334454-cqaado3u 40 35 on on IN cord-334454-cqaado3u 40 36 post post JJ cord-334454-cqaado3u 40 37 - - JJ cord-334454-cqaado3u 40 38 exposure exposure JJ cord-334454-cqaado3u 40 39 prophylaxis prophylaxis NN cord-334454-cqaado3u 40 40 [ [ -LRB- cord-334454-cqaado3u 40 41 15 15 CD cord-334454-cqaado3u 40 42 ] ] -RRB- cord-334454-cqaado3u 40 43 . . . cord-334454-cqaado3u 41 1 Not not RB cord-334454-cqaado3u 41 2 only only RB cord-334454-cqaado3u 41 3 in in IN cord-334454-cqaado3u 41 4 humans human NNS cord-334454-cqaado3u 41 5 but but CC cord-334454-cqaado3u 41 6 also also RB cord-334454-cqaado3u 41 7 in in IN cord-334454-cqaado3u 41 8 feline feline JJ cord-334454-cqaado3u 41 9 medicine medicine NN cord-334454-cqaado3u 41 10 , , , cord-334454-cqaado3u 41 11 the the DT cord-334454-cqaado3u 41 12 use use NN cord-334454-cqaado3u 41 13 of of IN cord-334454-cqaado3u 41 14 type type NN cord-334454-cqaado3u 41 15 I -PRON- PRP cord-334454-cqaado3u 41 16 IFNs ifns VBP cord-334454-cqaado3u 41 17 as as IN cord-334454-cqaado3u 41 18 immune immune JJ cord-334454-cqaado3u 41 19 modulation modulation NN cord-334454-cqaado3u 41 20 therapy therapy NN cord-334454-cqaado3u 41 21 is be VBZ cord-334454-cqaado3u 41 22 common common JJ cord-334454-cqaado3u 41 23 , , , cord-334454-cqaado3u 41 24 particularly particularly RB cord-334454-cqaado3u 41 25 in in IN cord-334454-cqaado3u 41 26 retroviral retroviral JJ cord-334454-cqaado3u 41 27 infections infection NNS cord-334454-cqaado3u 41 28 [ [ -LRB- cord-334454-cqaado3u 41 29 17 17 CD cord-334454-cqaado3u 41 30 ] ] -RRB- cord-334454-cqaado3u 41 31 [ [ -LRB- cord-334454-cqaado3u 41 32 18 18 CD cord-334454-cqaado3u 41 33 ] ] -RRB- cord-334454-cqaado3u 41 34 [ [ -LRB- cord-334454-cqaado3u 41 35 19 19 CD cord-334454-cqaado3u 41 36 ] ] -RRB- cord-334454-cqaado3u 41 37 . . . cord-334454-cqaado3u 42 1 Still still RB cord-334454-cqaado3u 42 2 used use VBN cord-334454-cqaado3u 42 3 in in IN cord-334454-cqaado3u 42 4 several several JJ cord-334454-cqaado3u 42 5 countries country NNS cord-334454-cqaado3u 42 6 , , , cord-334454-cqaado3u 42 7 HuIFN HuIFN NNP cord-334454-cqaado3u 42 8 - - HYPH cord-334454-cqaado3u 42 9 α α NNP cord-334454-cqaado3u 42 10 was be VBD cord-334454-cqaado3u 42 11 the the DT cord-334454-cqaado3u 42 12 first first JJ cord-334454-cqaado3u 42 13 interferon interferon NN cord-334454-cqaado3u 42 14 administered administer VBN cord-334454-cqaado3u 42 15 in in IN cord-334454-cqaado3u 42 16 cats cat NNS cord-334454-cqaado3u 42 17 , , , cord-334454-cqaado3u 42 18 despite despite IN cord-334454-cqaado3u 42 19 the the DT cord-334454-cqaado3u 42 20 fact fact NN cord-334454-cqaado3u 42 21 that that IN cord-334454-cqaado3u 42 22 it -PRON- PRP cord-334454-cqaado3u 42 23 is be VBZ cord-334454-cqaado3u 42 24 only only RB cord-334454-cqaado3u 42 25 licensed license VBN cord-334454-cqaado3u 42 26 for for IN cord-334454-cqaado3u 42 27 human human JJ cord-334454-cqaado3u 42 28 medicine medicine NN cord-334454-cqaado3u 42 29 [ [ -LRB- cord-334454-cqaado3u 42 30 4 4 CD cord-334454-cqaado3u 42 31 ] ] -RRB- cord-334454-cqaado3u 42 32 . . . cord-334454-cqaado3u 43 1 Among among IN cord-334454-cqaado3u 43 2 their -PRON- PRP$ cord-334454-cqaado3u 43 3 major major JJ cord-334454-cqaado3u 43 4 functions function NNS cord-334454-cqaado3u 43 5 , , , cord-334454-cqaado3u 43 6 it -PRON- PRP cord-334454-cqaado3u 43 7 was be VBD cord-334454-cqaado3u 43 8 shown show VBN cord-334454-cqaado3u 43 9 that that IN cord-334454-cqaado3u 43 10 HuIFN HuIFN NNP cord-334454-cqaado3u 43 11 - - HYPH cord-334454-cqaado3u 43 12 α α NNP cord-334454-cqaado3u 43 13 inhibits inhibit VBZ cord-334454-cqaado3u 43 14 oncogenic oncogenic JJ cord-334454-cqaado3u 43 15 mutations mutation NNS cord-334454-cqaado3u 43 16 induced induce VBN cord-334454-cqaado3u 43 17 by by IN cord-334454-cqaado3u 43 18 retroviruses retrovirus NNS cord-334454-cqaado3u 43 19 , , , cord-334454-cqaado3u 43 20 and and CC cord-334454-cqaado3u 43 21 it -PRON- PRP cord-334454-cqaado3u 43 22 restrains restrain VBZ cord-334454-cqaado3u 43 23 viral viral JJ cord-334454-cqaado3u 43 24 nucleic nucleic JJ cord-334454-cqaado3u 43 25 acid acid NN cord-334454-cqaado3u 43 26 synthesis synthesis NN cord-334454-cqaado3u 43 27 and and CC cord-334454-cqaado3u 43 28 suppress suppress VB cord-334454-cqaado3u 43 29 protein protein NN cord-334454-cqaado3u 43 30 production production NN cord-334454-cqaado3u 43 31 . . . cord-334454-cqaado3u 44 1 Due due IN cord-334454-cqaado3u 44 2 to to IN cord-334454-cqaado3u 44 3 these these DT cord-334454-cqaado3u 44 4 anti anti JJ cord-334454-cqaado3u 44 5 - - JJ cord-334454-cqaado3u 44 6 viral viral JJ cord-334454-cqaado3u 44 7 and and CC cord-334454-cqaado3u 44 8 immune immune JJ cord-334454-cqaado3u 44 9 modulation modulation NN cord-334454-cqaado3u 44 10 properties property NNS cord-334454-cqaado3u 44 11 , , , cord-334454-cqaado3u 44 12 HuIFN HuIFN NNP cord-334454-cqaado3u 44 13 - - HYPH cord-334454-cqaado3u 44 14 α α NNP cord-334454-cqaado3u 44 15 is be VBZ cord-334454-cqaado3u 44 16 used use VBN cord-334454-cqaado3u 44 17 with with IN cord-334454-cqaado3u 44 18 various various JJ cord-334454-cqaado3u 44 19 human human JJ cord-334454-cqaado3u 44 20 diseases disease NNS cord-334454-cqaado3u 44 21 such such JJ cord-334454-cqaado3u 44 22 as as IN cord-334454-cqaado3u 44 23 myeloid myeloid JJ cord-334454-cqaado3u 44 24 leukemia leukemia NN cord-334454-cqaado3u 44 25 , , , cord-334454-cqaado3u 44 26 papilomatosis papilomatosis NNP cord-334454-cqaado3u 44 27 , , , cord-334454-cqaado3u 44 28 and and CC cord-334454-cqaado3u 44 29 HIV HIV NNP cord-334454-cqaado3u 44 30 [ [ -LRB- cord-334454-cqaado3u 44 31 4 4 CD cord-334454-cqaado3u 44 32 ] ] -RRB- cord-334454-cqaado3u 44 33 . . . cord-334454-cqaado3u 45 1 For for IN cord-334454-cqaado3u 45 2 the the DT cord-334454-cqaado3u 45 3 same same JJ cord-334454-cqaado3u 45 4 reasons reason NNS cord-334454-cqaado3u 45 5 , , , cord-334454-cqaado3u 45 6 HuIFN HuIFN NNP cord-334454-cqaado3u 45 7 - - HYPH cord-334454-cqaado3u 45 8 α α NNP cord-334454-cqaado3u 45 9 has have VBZ cord-334454-cqaado3u 45 10 been be VBN cord-334454-cqaado3u 45 11 also also RB cord-334454-cqaado3u 45 12 used use VBN cord-334454-cqaado3u 45 13 in in IN cord-334454-cqaado3u 45 14 feline feline JJ cord-334454-cqaado3u 45 15 medicine medicine NN cord-334454-cqaado3u 45 16 , , , cord-334454-cqaado3u 45 17 namely namely RB cord-334454-cqaado3u 45 18 in in IN cord-334454-cqaado3u 45 19 FIV FIV NNP cord-334454-cqaado3u 45 20 , , , cord-334454-cqaado3u 45 21 FeLV FeLV NNP cord-334454-cqaado3u 45 22 , , , cord-334454-cqaado3u 45 23 FHV-1 FHV-1 NNP cord-334454-cqaado3u 45 24 , , , cord-334454-cqaado3u 45 25 FCV FCV NNP cord-334454-cqaado3u 45 26 , , , cord-334454-cqaado3u 45 27 and and CC cord-334454-cqaado3u 45 28 FCoV fcov JJ cord-334454-cqaado3u 45 29 viral viral JJ cord-334454-cqaado3u 45 30 infections infection NNS cord-334454-cqaado3u 45 31 [ [ -LRB- cord-334454-cqaado3u 45 32 20 20 CD cord-334454-cqaado3u 45 33 ] ] -RRB- cord-334454-cqaado3u 46 1 [ [ -LRB- cord-334454-cqaado3u 46 2 21 21 CD cord-334454-cqaado3u 46 3 ] ] -RRB- cord-334454-cqaado3u 46 4 [ [ -LRB- cord-334454-cqaado3u 46 5 22 22 CD cord-334454-cqaado3u 46 6 ] ] -RRB- cord-334454-cqaado3u 46 7 [ [ -LRB- cord-334454-cqaado3u 46 8 23 23 CD cord-334454-cqaado3u 46 9 ] ] -RRB- cord-334454-cqaado3u 46 10 . . . cord-334454-cqaado3u 47 1 In in IN cord-334454-cqaado3u 47 2 spite spite NN cord-334454-cqaado3u 47 3 of of IN cord-334454-cqaado3u 47 4 its -PRON- PRP$ cord-334454-cqaado3u 47 5 short short JJ cord-334454-cqaado3u 47 6 - - HYPH cord-334454-cqaado3u 47 7 term term NN cord-334454-cqaado3u 47 8 effects effect NNS cord-334454-cqaado3u 47 9 , , , cord-334454-cqaado3u 47 10 particularly particularly RB cord-334454-cqaado3u 47 11 on on IN cord-334454-cqaado3u 47 12 clinical clinical JJ cord-334454-cqaado3u 47 13 improvement improvement NN cord-334454-cqaado3u 47 14 and and CC cord-334454-cqaado3u 47 15 the the DT cord-334454-cqaado3u 47 16 increase increase NN cord-334454-cqaado3u 47 17 in in IN cord-334454-cqaado3u 47 18 survival survival NN cord-334454-cqaado3u 47 19 time time NN cord-334454-cqaado3u 47 20 , , , cord-334454-cqaado3u 47 21 the the DT cord-334454-cqaado3u 47 22 development development NN cord-334454-cqaado3u 47 23 of of IN cord-334454-cqaado3u 47 24 neutralizing neutralize VBG cord-334454-cqaado3u 47 25 antibodies antibody NNS cord-334454-cqaado3u 47 26 several several JJ cord-334454-cqaado3u 47 27 weeks week NNS cord-334454-cqaado3u 47 28 after after IN cord-334454-cqaado3u 47 29 therapy therapy NN cord-334454-cqaado3u 47 30 makes make VBZ cord-334454-cqaado3u 47 31 HuIFN HuIFN NNP cord-334454-cqaado3u 47 32 - - HYPH cord-334454-cqaado3u 47 33 α α NN cord-334454-cqaado3u 47 34 ineffective ineffective JJ cord-334454-cqaado3u 47 35 for for IN cord-334454-cqaado3u 47 36 long long JJ cord-334454-cqaado3u 47 37 - - HYPH cord-334454-cqaado3u 47 38 term term NN cord-334454-cqaado3u 47 39 immune immune JJ cord-334454-cqaado3u 47 40 modulation modulation NN cord-334454-cqaado3u 47 41 therapy therapy NN cord-334454-cqaado3u 47 42 in in IN cord-334454-cqaado3u 47 43 cats cat NNS cord-334454-cqaado3u 47 44 [ [ -LRB- cord-334454-cqaado3u 47 45 4 4 CD cord-334454-cqaado3u 47 46 , , , cord-334454-cqaado3u 47 47 19 19 CD cord-334454-cqaado3u 47 48 , , , cord-334454-cqaado3u 47 49 21 21 CD cord-334454-cqaado3u 47 50 ] ] -RRB- cord-334454-cqaado3u 47 51 . . . cord-334454-cqaado3u 48 1 This this DT cord-334454-cqaado3u 48 2 problem problem NN cord-334454-cqaado3u 48 3 was be VBD cord-334454-cqaado3u 48 4 bypassed bypass VBN cord-334454-cqaado3u 48 5 by by IN cord-334454-cqaado3u 48 6 the the DT cord-334454-cqaado3u 48 7 more more RBR cord-334454-cqaado3u 48 8 recent recent JJ cord-334454-cqaado3u 48 9 release release NN cord-334454-cqaado3u 48 10 of of IN cord-334454-cqaado3u 48 11 recombinant recombinant JJ cord-334454-cqaado3u 48 12 feline feline JJ cord-334454-cqaado3u 48 13 interferon interferon NN cord-334454-cqaado3u 48 14 omega omega NN cord-334454-cqaado3u 48 15 ( ( -LRB- cord-334454-cqaado3u 48 16 rFeIFN rFeIFN NNP cord-334454-cqaado3u 48 17 - - HYPH cord-334454-cqaado3u 48 18 ω ω CD cord-334454-cqaado3u 48 19 ) ) -RRB- cord-334454-cqaado3u 48 20 . . . cord-334454-cqaado3u 49 1 RFeIFN rfeifn NN cord-334454-cqaado3u 49 2 - - NNS cord-334454-cqaado3u 49 3 ω ω JJ cord-334454-cqaado3u 49 4 is be VBZ cord-334454-cqaado3u 49 5 the the DT cord-334454-cqaado3u 49 6 first first JJ cord-334454-cqaado3u 49 7 interferon interferon NN cord-334454-cqaado3u 49 8 compound compound NN cord-334454-cqaado3u 49 9 licensed license VBN cord-334454-cqaado3u 49 10 for for IN cord-334454-cqaado3u 49 11 use use NN cord-334454-cqaado3u 49 12 in in IN cord-334454-cqaado3u 49 13 veterinary veterinary JJ cord-334454-cqaado3u 49 14 medicine medicine NN cord-334454-cqaado3u 49 15 . . . cord-334454-cqaado3u 50 1 Specifically specifically RB cord-334454-cqaado3u 50 2 in in IN cord-334454-cqaado3u 50 3 cats cat NNS cord-334454-cqaado3u 50 4 , , , cord-334454-cqaado3u 50 5 this this DT cord-334454-cqaado3u 50 6 product product NN cord-334454-cqaado3u 50 7 is be VBZ cord-334454-cqaado3u 50 8 approved approve VBN cord-334454-cqaado3u 50 9 for for IN cord-334454-cqaado3u 50 10 use use NN cord-334454-cqaado3u 50 11 in in IN cord-334454-cqaado3u 50 12 retroviral retroviral JJ cord-334454-cqaado3u 50 13 infections infection NNS cord-334454-cqaado3u 50 14 , , , cord-334454-cqaado3u 50 15 namely namely RB cord-334454-cqaado3u 50 16 feline feline JJ cord-334454-cqaado3u 50 17 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 50 18 virus virus NN cord-334454-cqaado3u 50 19 ( ( -LRB- cord-334454-cqaado3u 50 20 FIV FIV NNP cord-334454-cqaado3u 50 21 ) ) -RRB- cord-334454-cqaado3u 50 22 and and CC cord-334454-cqaado3u 50 23 feline feline JJ cord-334454-cqaado3u 50 24 leukemia leukemia NN cord-334454-cqaado3u 50 25 virus virus NN cord-334454-cqaado3u 50 26 ( ( -LRB- cord-334454-cqaado3u 50 27 FeLV FeLV NNP cord-334454-cqaado3u 50 28 ) ) -RRB- cord-334454-cqaado3u 50 29 . . . cord-334454-cqaado3u 51 1 According accord VBG cord-334454-cqaado3u 51 2 to to IN cord-334454-cqaado3u 51 3 the the DT cord-334454-cqaado3u 51 4 manufacturer manufacturer NN cord-334454-cqaado3u 51 5 's 's POS cord-334454-cqaado3u 51 6 instructions instruction NNS cord-334454-cqaado3u 51 7 and and CC cord-334454-cqaado3u 51 8 license license NN cord-334454-cqaado3u 51 9 , , , cord-334454-cqaado3u 51 10 it -PRON- PRP cord-334454-cqaado3u 51 11 should should MD cord-334454-cqaado3u 51 12 be be VB cord-334454-cqaado3u 51 13 administered administer VBN cord-334454-cqaado3u 51 14 in in IN cord-334454-cqaado3u 51 15 three three CD cord-334454-cqaado3u 51 16 cycles cycle NNS cord-334454-cqaado3u 51 17 of of IN cord-334454-cqaado3u 51 18 five five CD cord-334454-cqaado3u 51 19 daily daily JJ cord-334454-cqaado3u 51 20 subcutaneous subcutaneous JJ cord-334454-cqaado3u 51 21 injections injection NNS cord-334454-cqaado3u 51 22 of of IN cord-334454-cqaado3u 51 23 1 1 CD cord-334454-cqaado3u 51 24 MU MU NNP cord-334454-cqaado3u 51 25 / / SYM cord-334454-cqaado3u 51 26 kg kg NN cord-334454-cqaado3u 51 27 , , , cord-334454-cqaado3u 51 28 beginning begin VBG cord-334454-cqaado3u 51 29 respectively respectively RB cord-334454-cqaado3u 51 30 on on IN cord-334454-cqaado3u 51 31 days day NNS cord-334454-cqaado3u 51 32 0 0 CD cord-334454-cqaado3u 51 33 , , , cord-334454-cqaado3u 51 34 14 14 CD cord-334454-cqaado3u 51 35 , , , cord-334454-cqaado3u 51 36 and and CC cord-334454-cqaado3u 51 37 60 60 CD cord-334454-cqaado3u 51 38 . . . cord-334454-cqaado3u 52 1 Despite despite IN cord-334454-cqaado3u 52 2 the the DT cord-334454-cqaado3u 52 3 fact fact NN cord-334454-cqaado3u 52 4 that that IN cord-334454-cqaado3u 52 5 it -PRON- PRP cord-334454-cqaado3u 52 6 was be VBD cord-334454-cqaado3u 52 7 licensed license VBN cord-334454-cqaado3u 52 8 a a DT cord-334454-cqaado3u 52 9 few few JJ cord-334454-cqaado3u 52 10 years year NNS cord-334454-cqaado3u 52 11 ago ago RB cord-334454-cqaado3u 52 12 , , , cord-334454-cqaado3u 52 13 only only RB cord-334454-cqaado3u 52 14 a a DT cord-334454-cqaado3u 52 15 few few JJ cord-334454-cqaado3u 52 16 studies study NNS cord-334454-cqaado3u 52 17 supported support VBD cord-334454-cqaado3u 52 18 its -PRON- PRP$ cord-334454-cqaado3u 52 19 clinical clinical JJ cord-334454-cqaado3u 52 20 benefits benefit NNS cord-334454-cqaado3u 52 21 , , , cord-334454-cqaado3u 52 22 particularly particularly RB cord-334454-cqaado3u 52 23 in in IN cord-334454-cqaado3u 52 24 retroviral retroviral JJ cord-334454-cqaado3u 52 25 infections infection NNS cord-334454-cqaado3u 52 26 . . . cord-334454-cqaado3u 53 1 The the DT cord-334454-cqaado3u 53 2 first first JJ cord-334454-cqaado3u 53 3 study study NN cord-334454-cqaado3u 53 4 , , , cord-334454-cqaado3u 53 5 which which WDT cord-334454-cqaado3u 53 6 described describe VBD cord-334454-cqaado3u 53 7 its -PRON- PRP$ cord-334454-cqaado3u 53 8 clinical clinical JJ cord-334454-cqaado3u 53 9 application application NN cord-334454-cqaado3u 53 10 dates date NNS cord-334454-cqaado3u 53 11 from from IN cord-334454-cqaado3u 53 12 2004 2004 CD cord-334454-cqaado3u 53 13 and and CC cord-334454-cqaado3u 53 14 reported report VBD cord-334454-cqaado3u 53 15 that that IN cord-334454-cqaado3u 53 16 treated treat VBN cord-334454-cqaado3u 53 17 feline feline JJ cord-334454-cqaado3u 53 18 leukemia leukemia NN cord-334454-cqaado3u 53 19 virus virus NN cord-334454-cqaado3u 53 20 ( ( -LRB- cord-334454-cqaado3u 53 21 FeLV FeLV NNP cord-334454-cqaado3u 53 22 ) ) -RRB- cord-334454-cqaado3u 53 23 and and CC cord-334454-cqaado3u 53 24 FIV FIV NNP cord-334454-cqaado3u 53 25 / / SYM cord-334454-cqaado3u 53 26 FeLV felv NN cord-334454-cqaado3u 53 27 co co JJ cord-334454-cqaado3u 53 28 - - JJ cord-334454-cqaado3u 53 29 infected infected JJ cord-334454-cqaado3u 53 30 cats cat NNS cord-334454-cqaado3u 53 31 , , , cord-334454-cqaado3u 53 32 showed show VBD cord-334454-cqaado3u 53 33 a a DT cord-334454-cqaado3u 53 34 significant significant JJ cord-334454-cqaado3u 53 35 clinical clinical JJ cord-334454-cqaado3u 53 36 improvement improvement NN cord-334454-cqaado3u 53 37 and and CC cord-334454-cqaado3u 53 38 an an DT cord-334454-cqaado3u 53 39 increased increase VBN cord-334454-cqaado3u 53 40 survival survival NN cord-334454-cqaado3u 53 41 time time NN cord-334454-cqaado3u 53 42 [ [ -LRB- cord-334454-cqaado3u 53 43 18 18 CD cord-334454-cqaado3u 53 44 ] ] -RRB- cord-334454-cqaado3u 53 45 . . . cord-334454-cqaado3u 54 1 More more RBR cord-334454-cqaado3u 54 2 recently recently RB cord-334454-cqaado3u 54 3 , , , cord-334454-cqaado3u 54 4 in in IN cord-334454-cqaado3u 54 5 2011 2011 CD cord-334454-cqaado3u 54 6 , , , cord-334454-cqaado3u 54 7 another another DT cord-334454-cqaado3u 54 8 research research NN cord-334454-cqaado3u 54 9 group group NN cord-334454-cqaado3u 54 10 reinforced reinforce VBD cord-334454-cqaado3u 54 11 that that IN cord-334454-cqaado3u 54 12 rFeIFN rFeIFN NNP cord-334454-cqaado3u 54 13 - - HYPH cord-334454-cqaado3u 54 14 ω ω NN cord-334454-cqaado3u 54 15 improves improve VBZ cord-334454-cqaado3u 54 16 clinical clinical JJ cord-334454-cqaado3u 54 17 signs sign NNS cord-334454-cqaado3u 54 18 and and CC cord-334454-cqaado3u 54 19 hematologic hematologic JJ cord-334454-cqaado3u 54 20 parameters parameter NNS cord-334454-cqaado3u 54 21 in in IN cord-334454-cqaado3u 54 22 retrovirally retrovirally RB cord-334454-cqaado3u 54 23 infected infected JJ cord-334454-cqaado3u 54 24 cats cat NNS cord-334454-cqaado3u 54 25 . . . cord-334454-cqaado3u 55 1 However however RB cord-334454-cqaado3u 55 2 , , , cord-334454-cqaado3u 55 3 according accord VBG cord-334454-cqaado3u 55 4 to to IN cord-334454-cqaado3u 55 5 this this DT cord-334454-cqaado3u 55 6 study study NN cord-334454-cqaado3u 55 7 , , , cord-334454-cqaado3u 55 8 it -PRON- PRP cord-334454-cqaado3u 55 9 does do VBZ cord-334454-cqaado3u 55 10 not not RB cord-334454-cqaado3u 55 11 change change VB cord-334454-cqaado3u 55 12 hypergammaglobulinemia hypergammaglobulinemia NN cord-334454-cqaado3u 55 13 , , , cord-334454-cqaado3u 55 14 proviral proviral NNP cord-334454-cqaado3u 55 15 load load NNP cord-334454-cqaado3u 55 16 , , , cord-334454-cqaado3u 55 17 or or CC cord-334454-cqaado3u 55 18 viremia viremia NN cord-334454-cqaado3u 55 19 , , , cord-334454-cqaado3u 55 20 suggesting suggest VBG cord-334454-cqaado3u 55 21 an an DT cord-334454-cqaado3u 55 22 overall overall JJ cord-334454-cqaado3u 55 23 effect effect NN cord-334454-cqaado3u 55 24 mainly mainly RB cord-334454-cqaado3u 55 25 on on IN cord-334454-cqaado3u 55 26 the the DT cord-334454-cqaado3u 55 27 innate innate JJ cord-334454-cqaado3u 55 28 immune immune JJ cord-334454-cqaado3u 55 29 reaction reaction NN cord-334454-cqaado3u 55 30 rather rather RB cord-334454-cqaado3u 55 31 than than IN cord-334454-cqaado3u 55 32 on on IN cord-334454-cqaado3u 55 33 the the DT cord-334454-cqaado3u 55 34 acquired acquire VBN cord-334454-cqaado3u 55 35 immunity immunity NN cord-334454-cqaado3u 55 36 [ [ -LRB- cord-334454-cqaado3u 55 37 17 17 CD cord-334454-cqaado3u 55 38 ] ] -RRB- cord-334454-cqaado3u 55 39 . . . cord-334454-cqaado3u 56 1 This this DT cord-334454-cqaado3u 56 2 means mean VBZ cord-334454-cqaado3u 56 3 that that IN cord-334454-cqaado3u 56 4 rFeIFN rfeifn NN cord-334454-cqaado3u 56 5 - - HYPH cord-334454-cqaado3u 56 6 ω ω NN cord-334454-cqaado3u 56 7 does do VBZ cord-334454-cqaado3u 56 8 not not RB cord-334454-cqaado3u 56 9 seem seem VB cord-334454-cqaado3u 56 10 to to TO cord-334454-cqaado3u 56 11 have have VB cord-334454-cqaado3u 56 12 an an DT cord-334454-cqaado3u 56 13 anti anti JJ cord-334454-cqaado3u 56 14 - - JJ cord-334454-cqaado3u 56 15 viral viral JJ cord-334454-cqaado3u 56 16 effect effect NN cord-334454-cqaado3u 56 17 in in IN cord-334454-cqaado3u 56 18 vivo vivo NN cord-334454-cqaado3u 56 19 , , , cord-334454-cqaado3u 56 20 and and CC cord-334454-cqaado3u 56 21 the the DT cord-334454-cqaado3u 56 22 observed observed JJ cord-334454-cqaado3u 56 23 clinical clinical JJ cord-334454-cqaado3u 56 24 improvement improvement NN cord-334454-cqaado3u 56 25 must must MD cord-334454-cqaado3u 56 26 be be VB cord-334454-cqaado3u 56 27 related relate VBN cord-334454-cqaado3u 56 28 to to IN cord-334454-cqaado3u 56 29 a a DT cord-334454-cqaado3u 56 30 potential potential JJ cord-334454-cqaado3u 56 31 immune immune JJ cord-334454-cqaado3u 56 32 modulation modulation NN cord-334454-cqaado3u 56 33 of of IN cord-334454-cqaado3u 56 34 the the DT cord-334454-cqaado3u 56 35 innate innate JJ cord-334454-cqaado3u 56 36 immune immune JJ cord-334454-cqaado3u 56 37 system system NN cord-334454-cqaado3u 56 38 [ [ -LRB- cord-334454-cqaado3u 56 39 17 17 CD cord-334454-cqaado3u 56 40 ] ] -RRB- cord-334454-cqaado3u 56 41 . . . cord-334454-cqaado3u 57 1 Moreover moreover RB cord-334454-cqaado3u 57 2 , , , cord-334454-cqaado3u 57 3 in in IN cord-334454-cqaado3u 57 4 contrast contrast NN cord-334454-cqaado3u 57 5 to to IN cord-334454-cqaado3u 57 6 in in FW cord-334454-cqaado3u 57 7 vitro vitro FW cord-334454-cqaado3u 57 8 studies study NNS cord-334454-cqaado3u 57 9 [ [ -LRB- cord-334454-cqaado3u 57 10 24 24 CD cord-334454-cqaado3u 57 11 ] ] -RRB- cord-334454-cqaado3u 57 12 , , , cord-334454-cqaado3u 57 13 the the DT cord-334454-cqaado3u 57 14 anti anti JJ cord-334454-cqaado3u 57 15 - - JJ cord-334454-cqaado3u 57 16 viral viral JJ cord-334454-cqaado3u 57 17 in in IN cord-334454-cqaado3u 57 18 vivo vivo NN cord-334454-cqaado3u 57 19 action action NN cord-334454-cqaado3u 57 20 of of IN cord-334454-cqaado3u 57 21 the the DT cord-334454-cqaado3u 57 22 rFeIFN rfeifn NN cord-334454-cqaado3u 57 23 - - HYPH cord-334454-cqaado3u 57 24 ω ω CD cord-334454-cqaado3u 57 25 licensed licensed JJ cord-334454-cqaado3u 57 26 protocol protocol NN cord-334454-cqaado3u 57 27 towards towards IN cord-334454-cqaado3u 57 28 FIV FIV NNP cord-334454-cqaado3u 57 29 and and CC cord-334454-cqaado3u 57 30 FeLV FeLV NNP cord-334454-cqaado3u 57 31 was be VBD cord-334454-cqaado3u 57 32 found find VBN cord-334454-cqaado3u 57 33 to to TO cord-334454-cqaado3u 57 34 be be VB cord-334454-cqaado3u 57 35 negligible negligible JJ cord-334454-cqaado3u 57 36 according accord VBG cord-334454-cqaado3u 57 37 to to IN cord-334454-cqaado3u 57 38 these these DT cord-334454-cqaado3u 57 39 authors author NNS cord-334454-cqaado3u 57 40 [ [ -LRB- cord-334454-cqaado3u 57 41 17 17 CD cord-334454-cqaado3u 57 42 ] ] -RRB- cord-334454-cqaado3u 57 43 . . . cord-334454-cqaado3u 58 1 These these DT cord-334454-cqaado3u 58 2 points point NNS cord-334454-cqaado3u 58 3 highlight highlight VBP cord-334454-cqaado3u 58 4 the the DT cord-334454-cqaado3u 58 5 need need NN cord-334454-cqaado3u 58 6 of of IN cord-334454-cqaado3u 58 7 further further JJ cord-334454-cqaado3u 58 8 studies study NNS cord-334454-cqaado3u 58 9 in in IN cord-334454-cqaado3u 58 10 order order NN cord-334454-cqaado3u 58 11 to to TO cord-334454-cqaado3u 58 12 clarify clarify VB cord-334454-cqaado3u 58 13 the the DT cord-334454-cqaado3u 58 14 mechanisms mechanism NNS cord-334454-cqaado3u 58 15 of of IN cord-334454-cqaado3u 58 16 action action NN cord-334454-cqaado3u 58 17 of of IN cord-334454-cqaado3u 58 18 rFeIFN rfeifn NN cord-334454-cqaado3u 58 19 - - HYPH cord-334454-cqaado3u 58 20 ω ω NN cord-334454-cqaado3u 58 21 . . . cord-334454-cqaado3u 59 1 The the DT cord-334454-cqaado3u 59 2 authors author NNS cord-334454-cqaado3u 59 3 tried try VBD cord-334454-cqaado3u 59 4 to to TO cord-334454-cqaado3u 59 5 extend extend VB cord-334454-cqaado3u 59 6 the the DT cord-334454-cqaado3u 59 7 current current JJ cord-334454-cqaado3u 59 8 knowledge knowledge NN cord-334454-cqaado3u 59 9 about about IN cord-334454-cqaado3u 59 10 this this DT cord-334454-cqaado3u 59 11 compound compound NN cord-334454-cqaado3u 59 12 in in IN cord-334454-cqaado3u 59 13 order order NN cord-334454-cqaado3u 59 14 to to TO cord-334454-cqaado3u 59 15 support support VB cord-334454-cqaado3u 59 16 and and CC cord-334454-cqaado3u 59 17 clarify clarify VB cord-334454-cqaado3u 59 18 the the DT cord-334454-cqaado3u 59 19 evident evident JJ cord-334454-cqaado3u 59 20 clinical clinical JJ cord-334454-cqaado3u 59 21 improvement improvement NN cord-334454-cqaado3u 59 22 previously previously RB cord-334454-cqaado3u 59 23 described describe VBD cord-334454-cqaado3u 59 24 [ [ -LRB- cord-334454-cqaado3u 59 25 17 17 CD cord-334454-cqaado3u 59 26 , , , cord-334454-cqaado3u 59 27 18 18 CD cord-334454-cqaado3u 59 28 ] ] -RRB- cord-334454-cqaado3u 59 29 . . . cord-334454-cqaado3u 60 1 Experimental experimental JJ cord-334454-cqaado3u 60 2 work work NN cord-334454-cqaado3u 60 3 relied rely VBD cord-334454-cqaado3u 60 4 on on IN cord-334454-cqaado3u 60 5 two two CD cord-334454-cqaado3u 60 6 distinct distinct JJ cord-334454-cqaado3u 60 7 clinical clinical JJ cord-334454-cqaado3u 60 8 trials trial NNS cord-334454-cqaado3u 60 9 [ [ -LRB- cord-334454-cqaado3u 60 10 25 25 CD cord-334454-cqaado3u 60 11 ] ] -RRB- cord-334454-cqaado3u 60 12 [ [ -LRB- cord-334454-cqaado3u 60 13 26 26 CD cord-334454-cqaado3u 60 14 ] ] -RRB- cord-334454-cqaado3u 60 15 [ [ -LRB- cord-334454-cqaado3u 60 16 27 27 CD cord-334454-cqaado3u 60 17 ] ] -RRB- cord-334454-cqaado3u 60 18 . . . cord-334454-cqaado3u 61 1 One one CD cord-334454-cqaado3u 61 2 referred refer VBD cord-334454-cqaado3u 61 3 to to IN cord-334454-cqaado3u 61 4 16 16 CD cord-334454-cqaado3u 61 5 retrovirally retrovirally NN cord-334454-cqaado3u 61 6 infected infected JJ cord-334454-cqaado3u 61 7 cats cat NNS cord-334454-cqaado3u 61 8 ( ( -LRB- cord-334454-cqaado3u 61 9 7 7 CD cord-334454-cqaado3u 61 10 FIV FIV NNP cord-334454-cqaado3u 61 11 , , , cord-334454-cqaado3u 61 12 6 6 CD cord-334454-cqaado3u 61 13 FeLV felv NN cord-334454-cqaado3u 61 14 , , , cord-334454-cqaado3u 61 15 and and CC cord-334454-cqaado3u 61 16 3 3 CD cord-334454-cqaado3u 61 17 co co JJ cord-334454-cqaado3u 61 18 - - JJ cord-334454-cqaado3u 61 19 infected infected JJ cord-334454-cqaado3u 61 20 cats cat NNS cord-334454-cqaado3u 61 21 ) ) -RRB- cord-334454-cqaado3u 61 22 treated treat VBN cord-334454-cqaado3u 61 23 with with IN cord-334454-cqaado3u 61 24 rFeIFN rFeIFN NNP cord-334454-cqaado3u 61 25 - - HYPH cord-334454-cqaado3u 61 26 ω ω CD cord-334454-cqaado3u 61 27 licensed license VBD cord-334454-cqaado3u 61 28 subcutaneous subcutaneous JJ cord-334454-cqaado3u 61 29 protocol protocol NN cord-334454-cqaado3u 61 30 , , , cord-334454-cqaado3u 61 31 while while IN cord-334454-cqaado3u 61 32 the the DT cord-334454-cqaado3u 61 33 other other JJ cord-334454-cqaado3u 61 34 described describe VBD cord-334454-cqaado3u 61 35 an an DT cord-334454-cqaado3u 61 36 alternative alternative JJ cord-334454-cqaado3u 61 37 oral oral JJ cord-334454-cqaado3u 61 38 rFeIFN rfeifn NN cord-334454-cqaado3u 61 39 - - HYPH cord-334454-cqaado3u 61 40 ω ω CD cord-334454-cqaado3u 61 41 protocol protocol NN cord-334454-cqaado3u 61 42 , , , cord-334454-cqaado3u 61 43 administered administer VBN cord-334454-cqaado3u 61 44 to to IN cord-334454-cqaado3u 61 45 11 11 CD cord-334454-cqaado3u 61 46 FIV FIV NNP cord-334454-cqaado3u 61 47 - - HYPH cord-334454-cqaado3u 61 48 infected infect VBN cord-334454-cqaado3u 61 49 cats cat NNS cord-334454-cqaado3u 61 50 [ [ -LRB- cord-334454-cqaado3u 61 51 25 25 CD cord-334454-cqaado3u 61 52 , , , cord-334454-cqaado3u 61 53 26 26 CD cord-334454-cqaado3u 61 54 ] ] -RRB- cord-334454-cqaado3u 61 55 . . . cord-334454-cqaado3u 62 1 Both both DT cord-334454-cqaado3u 62 2 protocols protocol NNS cord-334454-cqaado3u 62 3 were be VBD cord-334454-cqaado3u 62 4 compared compare VBN cord-334454-cqaado3u 62 5 in in IN cord-334454-cqaado3u 62 6 an an DT cord-334454-cqaado3u 62 7 immunological immunological JJ cord-334454-cqaado3u 62 8 and and CC cord-334454-cqaado3u 62 9 virological virological JJ cord-334454-cqaado3u 62 10 perspective perspective NN cord-334454-cqaado3u 62 11 [ [ -LRB- cord-334454-cqaado3u 62 12 25 25 CD cord-334454-cqaado3u 62 13 ] ] -RRB- cord-334454-cqaado3u 62 14 [ [ -LRB- cord-334454-cqaado3u 62 15 26 26 CD cord-334454-cqaado3u 62 16 ] ] -RRB- cord-334454-cqaado3u 62 17 [ [ -LRB- cord-334454-cqaado3u 62 18 27 27 CD cord-334454-cqaado3u 62 19 ] ] -RRB- cord-334454-cqaado3u 62 20 . . . cord-334454-cqaado3u 63 1 Firstly firstly RB cord-334454-cqaado3u 63 2 , , , cord-334454-cqaado3u 63 3 the the DT cord-334454-cqaado3u 63 4 effect effect NN cord-334454-cqaado3u 63 5 of of IN cord-334454-cqaado3u 63 6 rFeIFN rFeIFN NNP cord-334454-cqaado3u 63 7 - - HYPH cord-334454-cqaado3u 63 8 ω ω CD cord-334454-cqaado3u 63 9 licensed licensed JJ cord-334454-cqaado3u 63 10 protocol protocol NN cord-334454-cqaado3u 63 11 in in IN cord-334454-cqaado3u 63 12 cats cat NNS cord-334454-cqaado3u 63 13 living live VBG cord-334454-cqaado3u 63 14 in in IN cord-334454-cqaado3u 63 15 an an DT cord-334454-cqaado3u 63 16 animal animal NN cord-334454-cqaado3u 63 17 shelter shelter NN cord-334454-cqaado3u 63 18 was be VBD cord-334454-cqaado3u 63 19 evaluated evaluate VBN cord-334454-cqaado3u 63 20 , , , cord-334454-cqaado3u 63 21 assessing assess VBG cord-334454-cqaado3u 63 22 clinical clinical JJ cord-334454-cqaado3u 63 23 improvement improvement NN cord-334454-cqaado3u 63 24 and and CC cord-334454-cqaado3u 63 25 monitoring monitor VBG cord-334454-cqaado3u 63 26 concurrent concurrent JJ cord-334454-cqaado3u 63 27 viral viral JJ cord-334454-cqaado3u 63 28 excretion excretion NN cord-334454-cqaado3u 63 29 ( ( -LRB- cord-334454-cqaado3u 63 30 namely namely RB cord-334454-cqaado3u 63 31 herpesvirus herpesvirus NNP cord-334454-cqaado3u 63 32 , , , cord-334454-cqaado3u 63 33 calicivirus calicivirus NNP cord-334454-cqaado3u 63 34 , , , cord-334454-cqaado3u 63 35 and and CC cord-334454-cqaado3u 63 36 coronavirus coronavirus NN cord-334454-cqaado3u 63 37 ) ) -RRB- cord-334454-cqaado3u 63 38 [ [ -LRB- cord-334454-cqaado3u 63 39 26 26 CD cord-334454-cqaado3u 63 40 ] ] -RRB- cord-334454-cqaado3u 63 41 . . . cord-334454-cqaado3u 64 1 A a DT cord-334454-cqaado3u 64 2 previous previous JJ cord-334454-cqaado3u 64 3 study study NN cord-334454-cqaado3u 64 4 in in IN cord-334454-cqaado3u 64 5 cats cat NNS cord-334454-cqaado3u 64 6 treated treat VBN cord-334454-cqaado3u 64 7 with with IN cord-334454-cqaado3u 64 8 HuIFN HuIFN NNP cord-334454-cqaado3u 64 9 - - HYPH cord-334454-cqaado3u 64 10 α α NNP cord-334454-cqaado3u 64 11 documented document VBD cord-334454-cqaado3u 64 12 that that IN cord-334454-cqaado3u 64 13 the the DT cord-334454-cqaado3u 64 14 induced induce VBN cord-334454-cqaado3u 64 15 clinical clinical JJ cord-334454-cqaado3u 64 16 improvement improvement NN cord-334454-cqaado3u 64 17 could could MD cord-334454-cqaado3u 64 18 be be VB cord-334454-cqaado3u 64 19 potentially potentially RB cord-334454-cqaado3u 64 20 related relate VBN cord-334454-cqaado3u 64 21 to to IN cord-334454-cqaado3u 64 22 a a DT cord-334454-cqaado3u 64 23 recovery recovery NN cord-334454-cqaado3u 64 24 of of IN cord-334454-cqaado3u 64 25 serious serious JJ cord-334454-cqaado3u 64 26 opportunistic opportunistic JJ cord-334454-cqaado3u 64 27 infections infection NNS cord-334454-cqaado3u 64 28 [ [ -LRB- cord-334454-cqaado3u 64 29 21 21 CD cord-334454-cqaado3u 64 30 ] ] -RRB- cord-334454-cqaado3u 64 31 . . . cord-334454-cqaado3u 65 1 In in IN cord-334454-cqaado3u 65 2 order order NN cord-334454-cqaado3u 65 3 to to TO cord-334454-cqaado3u 65 4 assess assess VB cord-334454-cqaado3u 65 5 whether whether IN cord-334454-cqaado3u 65 6 rFeIFN rFeIFN NNP cord-334454-cqaado3u 65 7 - - HYPH cord-334454-cqaado3u 65 8 ω ω NN cord-334454-cqaado3u 65 9 had have VBD cord-334454-cqaado3u 65 10 the the DT cord-334454-cqaado3u 65 11 same same JJ cord-334454-cqaado3u 65 12 properties property NNS cord-334454-cqaado3u 65 13 , , , cord-334454-cqaado3u 65 14 different different JJ cord-334454-cqaado3u 65 15 hematology hematology NN cord-334454-cqaado3u 65 16 and and CC cord-334454-cqaado3u 65 17 biochemistry biochemistry NN cord-334454-cqaado3u 65 18 parameters parameter NNS cord-334454-cqaado3u 65 19 were be VBD cord-334454-cqaado3u 65 20 monitored monitor VBN cord-334454-cqaado3u 65 21 , , , cord-334454-cqaado3u 65 22 and and CC cord-334454-cqaado3u 65 23 a a DT cord-334454-cqaado3u 65 24 score score NN cord-334454-cqaado3u 65 25 - - HYPH cord-334454-cqaado3u 65 26 scale scale NN cord-334454-cqaado3u 65 27 system system NN cord-334454-cqaado3u 65 28 that that WDT cord-334454-cqaado3u 65 29 allowed allow VBD cord-334454-cqaado3u 65 30 the the DT cord-334454-cqaado3u 65 31 evaluation evaluation NN cord-334454-cqaado3u 65 32 of of IN cord-334454-cqaado3u 65 33 clinical clinical JJ cord-334454-cqaado3u 65 34 improvement improvement NN cord-334454-cqaado3u 65 35 in in IN cord-334454-cqaado3u 65 36 treated treat VBN cord-334454-cqaado3u 65 37 cats cat NNS cord-334454-cqaado3u 65 38 was be VBD cord-334454-cqaado3u 65 39 validated validate VBN cord-334454-cqaado3u 65 40 . . . cord-334454-cqaado3u 66 1 In in IN cord-334454-cqaado3u 66 2 agreement agreement NN cord-334454-cqaado3u 66 3 with with IN cord-334454-cqaado3u 66 4 the the DT cord-334454-cqaado3u 66 5 two two CD cord-334454-cqaado3u 66 6 previous previous JJ cord-334454-cqaado3u 66 7 referred refer VBN cord-334454-cqaado3u 66 8 studies study NNS cord-334454-cqaado3u 66 9 [ [ -LRB- cord-334454-cqaado3u 66 10 17 17 CD cord-334454-cqaado3u 66 11 , , , cord-334454-cqaado3u 66 12 18 18 CD cord-334454-cqaado3u 66 13 ] ] -RRB- cord-334454-cqaado3u 66 14 , , , cord-334454-cqaado3u 66 15 a a DT cord-334454-cqaado3u 66 16 significant significant JJ cord-334454-cqaado3u 66 17 clinical clinical JJ cord-334454-cqaado3u 66 18 improvement improvement NN cord-334454-cqaado3u 66 19 in in IN cord-334454-cqaado3u 66 20 treated treat VBN cord-334454-cqaado3u 66 21 animals animal NNS cord-334454-cqaado3u 66 22 without without IN cord-334454-cqaado3u 66 23 relevant relevant JJ cord-334454-cqaado3u 66 24 changes change NNS cord-334454-cqaado3u 66 25 on on IN cord-334454-cqaado3u 66 26 hematology hematology NN cord-334454-cqaado3u 66 27 and and CC cord-334454-cqaado3u 66 28 biochemistry biochemistry NN cord-334454-cqaado3u 66 29 profiles profile NNS cord-334454-cqaado3u 66 30 was be VBD cord-334454-cqaado3u 66 31 reported report VBN cord-334454-cqaado3u 66 32 [ [ -LRB- cord-334454-cqaado3u 66 33 26 26 CD cord-334454-cqaado3u 66 34 ] ] -RRB- cord-334454-cqaado3u 66 35 . . . cord-334454-cqaado3u 67 1 Concerning concern VBG cord-334454-cqaado3u 67 2 these these DT cord-334454-cqaado3u 67 3 results result NNS cord-334454-cqaado3u 67 4 , , , cord-334454-cqaado3u 67 5 rFeIFNω rFeIFNω NNP cord-334454-cqaado3u 67 6 seems seem VBZ cord-334454-cqaado3u 67 7 to to TO cord-334454-cqaado3u 67 8 be be VB cord-334454-cqaado3u 67 9 able able JJ cord-334454-cqaado3u 67 10 to to TO cord-334454-cqaado3u 67 11 contribute contribute VB cord-334454-cqaado3u 67 12 to to IN cord-334454-cqaado3u 67 13 the the DT cord-334454-cqaado3u 67 14 management management NN cord-334454-cqaado3u 67 15 of of IN cord-334454-cqaado3u 67 16 this this DT cord-334454-cqaado3u 67 17 reality reality NN cord-334454-cqaado3u 67 18 by by IN cord-334454-cqaado3u 67 19 improving improve VBG cord-334454-cqaado3u 67 20 clinical clinical JJ cord-334454-cqaado3u 67 21 signs sign NNS cord-334454-cqaado3u 67 22 and and CC cord-334454-cqaado3u 67 23 decreasing decrease VBG cord-334454-cqaado3u 67 24 concurrent concurrent JJ cord-334454-cqaado3u 67 25 viral viral JJ cord-334454-cqaado3u 67 26 excretion excretion NN cord-334454-cqaado3u 67 27 . . . cord-334454-cqaado3u 68 1 Therefore therefore RB cord-334454-cqaado3u 68 2 , , , cord-334454-cqaado3u 68 3 rFeIFNω rFeIFNω NNP cord-334454-cqaado3u 68 4 must must MD cord-334454-cqaado3u 68 5 be be VB cord-334454-cqaado3u 68 6 considered consider VBN cord-334454-cqaado3u 68 7 as as IN cord-334454-cqaado3u 68 8 an an DT cord-334454-cqaado3u 68 9 effective effective JJ cord-334454-cqaado3u 68 10 immune immune JJ cord-334454-cqaado3u 68 11 - - HYPH cord-334454-cqaado3u 68 12 modulator modulator NN cord-334454-cqaado3u 68 13 therapy therapy NN cord-334454-cqaado3u 68 14 for for IN cord-334454-cqaado3u 68 15 use use NN cord-334454-cqaado3u 68 16 in in IN cord-334454-cqaado3u 68 17 shelter shelter NN cord-334454-cqaado3u 68 18 medicine medicine NN cord-334454-cqaado3u 68 19 where where WRB cord-334454-cqaado3u 68 20 the the DT cord-334454-cqaado3u 68 21 prevalence prevalence NN cord-334454-cqaado3u 68 22 of of IN cord-334454-cqaado3u 68 23 concomitant concomitant JJ cord-334454-cqaado3u 68 24 infections infection NNS cord-334454-cqaado3u 68 25 is be VBZ cord-334454-cqaado3u 68 26 higher high JJR cord-334454-cqaado3u 68 27 . . . cord-334454-cqaado3u 69 1 In in IN cord-334454-cqaado3u 69 2 further further JJ cord-334454-cqaado3u 69 3 studies study NNS cord-334454-cqaado3u 69 4 , , , cord-334454-cqaado3u 69 5 the the DT cord-334454-cqaado3u 69 6 influence influence NN cord-334454-cqaado3u 69 7 of of IN cord-334454-cqaado3u 69 8 rFeIFN rfeifn NN cord-334454-cqaado3u 69 9 - - HYPH cord-334454-cqaado3u 69 10 ω ω JJ cord-334454-cqaado3u 69 11 in in IN cord-334454-cqaado3u 69 12 the the DT cord-334454-cqaado3u 69 13 acute acute JJ cord-334454-cqaado3u 69 14 phase phase NN cord-334454-cqaado3u 69 15 reaction reaction NN cord-334454-cqaado3u 69 16 was be VBD cord-334454-cqaado3u 69 17 investigated investigate VBN cord-334454-cqaado3u 69 18 [ [ -LRB- cord-334454-cqaado3u 69 19 28 28 CD cord-334454-cqaado3u 69 20 ] ] -RRB- cord-334454-cqaado3u 69 21 . . . cord-334454-cqaado3u 70 1 In in IN cord-334454-cqaado3u 70 2 human human JJ cord-334454-cqaado3u 70 3 medicine medicine NN cord-334454-cqaado3u 70 4 , , , cord-334454-cqaado3u 70 5 several several JJ cord-334454-cqaado3u 70 6 studies study NNS cord-334454-cqaado3u 70 7 have have VBP cord-334454-cqaado3u 70 8 described describe VBN cord-334454-cqaado3u 70 9 its -PRON- PRP$ cord-334454-cqaado3u 70 10 increase increase NN cord-334454-cqaado3u 70 11 in in IN cord-334454-cqaado3u 70 12 HIV HIV NNP cord-334454-cqaado3u 70 13 - - HYPH cord-334454-cqaado3u 70 14 positive positive JJ cord-334454-cqaado3u 70 15 patients patient NNS cord-334454-cqaado3u 70 16 [ [ -LRB- cord-334454-cqaado3u 70 17 29 29 CD cord-334454-cqaado3u 70 18 , , , cord-334454-cqaado3u 70 19 30 30 CD cord-334454-cqaado3u 70 20 ] ] -RRB- cord-334454-cqaado3u 70 21 , , , cord-334454-cqaado3u 70 22 even even RB cord-334454-cqaado3u 70 23 after after IN cord-334454-cqaado3u 70 24 immunomodulation immunomodulation NN cord-334454-cqaado3u 70 25 therapy therapy NN cord-334454-cqaado3u 70 26 with with IN cord-334454-cqaado3u 70 27 exogenous exogenous JJ cord-334454-cqaado3u 70 28 IL-2 IL-2 NNP cord-334454-cqaado3u 70 29 [ [ -LRB- cord-334454-cqaado3u 70 30 31 31 CD cord-334454-cqaado3u 70 31 ] ] -RRB- cord-334454-cqaado3u 70 32 . . . cord-334454-cqaado3u 71 1 Despite despite IN cord-334454-cqaado3u 71 2 the the DT cord-334454-cqaado3u 71 3 similarity similarity NN cord-334454-cqaado3u 71 4 between between IN cord-334454-cqaado3u 71 5 HIV HIV NNP cord-334454-cqaado3u 71 6 and and CC cord-334454-cqaado3u 71 7 FIV FIV NNP cord-334454-cqaado3u 71 8 [ [ -LRB- cord-334454-cqaado3u 71 9 2 2 CD cord-334454-cqaado3u 71 10 , , , cord-334454-cqaado3u 71 11 32 32 CD cord-334454-cqaado3u 71 12 ] ] -RRB- cord-334454-cqaado3u 71 13 , , , cord-334454-cqaado3u 71 14 the the DT cord-334454-cqaado3u 71 15 CRP CRP NNP cord-334454-cqaado3u 71 16 behavior behavior NN cord-334454-cqaado3u 71 17 in in IN cord-334454-cqaado3u 71 18 FIV fiv NN cord-334454-cqaado3u 71 19 - - HYPH cord-334454-cqaado3u 71 20 positive positive JJ cord-334454-cqaado3u 71 21 cats cat NNS cord-334454-cqaado3u 71 22 undergoing undergo VBG cord-334454-cqaado3u 71 23 immune immune JJ cord-334454-cqaado3u 71 24 - - HYPH cord-334454-cqaado3u 71 25 modulation modulation NN cord-334454-cqaado3u 71 26 therapy therapy NN cord-334454-cqaado3u 71 27 remains remain VBZ cord-334454-cqaado3u 71 28 unknown unknown JJ cord-334454-cqaado3u 71 29 . . . cord-334454-cqaado3u 72 1 Following follow VBG cord-334454-cqaado3u 72 2 previous previous JJ cord-334454-cqaado3u 72 3 conclusions conclusion NNS cord-334454-cqaado3u 72 4 suggesting suggest VBG cord-334454-cqaado3u 72 5 that that IN cord-334454-cqaado3u 72 6 this this DT cord-334454-cqaado3u 72 7 compound compound NN cord-334454-cqaado3u 72 8 acts act VBZ cord-334454-cqaado3u 72 9 on on IN cord-334454-cqaado3u 72 10 the the DT cord-334454-cqaado3u 72 11 innate innate JJ cord-334454-cqaado3u 72 12 response response NN cord-334454-cqaado3u 72 13 rather rather RB cord-334454-cqaado3u 72 14 than than IN cord-334454-cqaado3u 72 15 on on IN cord-334454-cqaado3u 72 16 the the DT cord-334454-cqaado3u 72 17 acquired acquire VBN cord-334454-cqaado3u 72 18 immune immune JJ cord-334454-cqaado3u 72 19 system system NN cord-334454-cqaado3u 72 20 , , , cord-334454-cqaado3u 72 21 its -PRON- PRP$ cord-334454-cqaado3u 72 22 effect effect NN cord-334454-cqaado3u 72 23 on on IN cord-334454-cqaado3u 72 24 acute acute JJ cord-334454-cqaado3u 72 25 phase phase NN cord-334454-cqaado3u 72 26 proteins protein NNS cord-334454-cqaado3u 72 27 ( ( -LRB- cord-334454-cqaado3u 72 28 APPs app NNS cord-334454-cqaado3u 72 29 ) ) -RRB- cord-334454-cqaado3u 72 30 was be VBD cord-334454-cqaado3u 72 31 evaluated evaluate VBN cord-334454-cqaado3u 72 32 [ [ -LRB- cord-334454-cqaado3u 72 33 17 17 CD cord-334454-cqaado3u 72 34 ] ] -RRB- cord-334454-cqaado3u 72 35 . . . cord-334454-cqaado3u 73 1 Taking take VBG cord-334454-cqaado3u 73 2 into into IN cord-334454-cqaado3u 73 3 account account NN cord-334454-cqaado3u 73 4 that that IN cord-334454-cqaado3u 73 5 APPs app NNS cord-334454-cqaado3u 73 6 are be VBP cord-334454-cqaado3u 73 7 one one CD cord-334454-cqaado3u 73 8 of of IN cord-334454-cqaado3u 73 9 the the DT cord-334454-cqaado3u 73 10 key key JJ cord-334454-cqaado3u 73 11 components component NNS cord-334454-cqaado3u 73 12 of of IN cord-334454-cqaado3u 73 13 the the DT cord-334454-cqaado3u 73 14 innate innate JJ cord-334454-cqaado3u 73 15 immune immune JJ cord-334454-cqaado3u 73 16 system system NN cord-334454-cqaado3u 73 17 , , , cord-334454-cqaado3u 73 18 they -PRON- PRP cord-334454-cqaado3u 73 19 seemed seem VBD cord-334454-cqaado3u 73 20 reasonable reasonable JJ cord-334454-cqaado3u 73 21 predictors predictor NNS cord-334454-cqaado3u 73 22 of of IN cord-334454-cqaado3u 73 23 an an DT cord-334454-cqaado3u 73 24 innate innate JJ cord-334454-cqaado3u 73 25 immune immune JJ cord-334454-cqaado3u 73 26 - - HYPH cord-334454-cqaado3u 73 27 stimulation stimulation NN cord-334454-cqaado3u 73 28 [ [ -LRB- cord-334454-cqaado3u 73 29 33 33 CD cord-334454-cqaado3u 73 30 ] ] -RRB- cord-334454-cqaado3u 73 31 . . . cord-334454-cqaado3u 74 1 Authors author NNS cord-334454-cqaado3u 74 2 showed show VBD cord-334454-cqaado3u 74 3 that that IN cord-334454-cqaado3u 74 4 APPs app NNS cord-334454-cqaado3u 74 5 significantly significantly RB cord-334454-cqaado3u 74 6 increased increase VBD cord-334454-cqaado3u 74 7 in in IN cord-334454-cqaado3u 74 8 cats cat NNS cord-334454-cqaado3u 74 9 treated treat VBN cord-334454-cqaado3u 74 10 with with IN cord-334454-cqaado3u 74 11 the the DT cord-334454-cqaado3u 74 12 licensed license VBN cord-334454-cqaado3u 74 13 rFeIFN rfeifn NN cord-334454-cqaado3u 74 14 - - HYPH cord-334454-cqaado3u 74 15 ω ω CD cord-334454-cqaado3u 74 16 protocol protocol NN cord-334454-cqaado3u 74 17 [ [ -LRB- cord-334454-cqaado3u 74 18 28 28 CD cord-334454-cqaado3u 74 19 ] ] -RRB- cord-334454-cqaado3u 74 20 . . . cord-334454-cqaado3u 75 1 Despite despite IN cord-334454-cqaado3u 75 2 the the DT cord-334454-cqaado3u 75 3 fact fact NN cord-334454-cqaado3u 75 4 that that IN cord-334454-cqaado3u 75 5 APPs app NNS cord-334454-cqaado3u 75 6 usually usually RB cord-334454-cqaado3u 75 7 increase increase VBP cord-334454-cqaado3u 75 8 in in IN cord-334454-cqaado3u 75 9 different different JJ cord-334454-cqaado3u 75 10 situations situation NNS cord-334454-cqaado3u 75 11 such such JJ cord-334454-cqaado3u 75 12 as as IN cord-334454-cqaado3u 75 13 chronic chronic JJ cord-334454-cqaado3u 75 14 infection infection NN cord-334454-cqaado3u 75 15 and and CC cord-334454-cqaado3u 75 16 severe severe JJ cord-334454-cqaado3u 75 17 inflammation inflammation NN cord-334454-cqaado3u 75 18 [ [ -LRB- cord-334454-cqaado3u 75 19 33 33 CD cord-334454-cqaado3u 75 20 , , , cord-334454-cqaado3u 75 21 34 34 CD cord-334454-cqaado3u 75 22 ] ] -RRB- cord-334454-cqaado3u 75 23 , , , cord-334454-cqaado3u 75 24 in in IN cord-334454-cqaado3u 75 25 this this DT cord-334454-cqaado3u 75 26 study study NN cord-334454-cqaado3u 75 27 , , , cord-334454-cqaado3u 75 28 their -PRON- PRP$ cord-334454-cqaado3u 75 29 increment increment NN cord-334454-cqaado3u 75 30 was be VBD cord-334454-cqaado3u 75 31 concomitant concomitant JJ cord-334454-cqaado3u 75 32 with with IN cord-334454-cqaado3u 75 33 the the DT cord-334454-cqaado3u 75 34 described describe VBN cord-334454-cqaado3u 75 35 clinical clinical JJ cord-334454-cqaado3u 75 36 improvement improvement NN cord-334454-cqaado3u 75 37 and and CC cord-334454-cqaado3u 75 38 reduction reduction NN cord-334454-cqaado3u 75 39 in in IN cord-334454-cqaado3u 75 40 opportunistic opportunistic JJ cord-334454-cqaado3u 75 41 infections infection NNS cord-334454-cqaado3u 75 42 . . . cord-334454-cqaado3u 76 1 This this DT cord-334454-cqaado3u 76 2 work work NN cord-334454-cqaado3u 76 3 showed show VBD cord-334454-cqaado3u 76 4 that that IN cord-334454-cqaado3u 76 5 the the DT cord-334454-cqaado3u 76 6 APP app NN cord-334454-cqaado3u 76 7 increment increment NN cord-334454-cqaado3u 76 8 might may MD cord-334454-cqaado3u 76 9 be be VB cord-334454-cqaado3u 76 10 beneficial beneficial JJ cord-334454-cqaado3u 76 11 in in IN cord-334454-cqaado3u 76 12 retrovirally retrovirally NN cord-334454-cqaado3u 76 13 infected infected JJ cord-334454-cqaado3u 76 14 cats cat NNS cord-334454-cqaado3u 76 15 , , , cord-334454-cqaado3u 76 16 confirming confirm VBG cord-334454-cqaado3u 76 17 that that IN cord-334454-cqaado3u 76 18 they -PRON- PRP cord-334454-cqaado3u 76 19 can can MD cord-334454-cqaado3u 76 20 be be VB cord-334454-cqaado3u 76 21 a a DT cord-334454-cqaado3u 76 22 reasonable reasonable JJ cord-334454-cqaado3u 76 23 indicator indicator NN cord-334454-cqaado3u 76 24 of of IN cord-334454-cqaado3u 76 25 a a DT cord-334454-cqaado3u 76 26 potentiated potentiate VBN cord-334454-cqaado3u 76 27 innate innate JJ cord-334454-cqaado3u 76 28 immune immune JJ cord-334454-cqaado3u 76 29 response response NN cord-334454-cqaado3u 76 30 . . . cord-334454-cqaado3u 77 1 Being be VBG cord-334454-cqaado3u 77 2 the the DT cord-334454-cqaado3u 77 3 first first JJ cord-334454-cqaado3u 77 4 work work NN cord-334454-cqaado3u 77 5 documenting document VBG cord-334454-cqaado3u 77 6 the the DT cord-334454-cqaado3u 77 7 effect effect NN cord-334454-cqaado3u 77 8 of of IN cord-334454-cqaado3u 77 9 rFeIFN rfeifn NN cord-334454-cqaado3u 77 10 - - HYPH cord-334454-cqaado3u 77 11 ω ω NN cord-334454-cqaado3u 77 12 on on IN cord-334454-cqaado3u 77 13 APP app NN cord-334454-cqaado3u 77 14 profiles profile NNS cord-334454-cqaado3u 77 15 , , , cord-334454-cqaado3u 77 16 this this DT cord-334454-cqaado3u 77 17 study study NN cord-334454-cqaado3u 77 18 reinforces reinforce VBZ cord-334454-cqaado3u 77 19 the the DT cord-334454-cqaado3u 77 20 action action NN cord-334454-cqaado3u 77 21 of of IN cord-334454-cqaado3u 77 22 this this DT cord-334454-cqaado3u 77 23 compound compound NN cord-334454-cqaado3u 77 24 on on IN cord-334454-cqaado3u 77 25 the the DT cord-334454-cqaado3u 77 26 innate innate JJ cord-334454-cqaado3u 77 27 immune immune JJ cord-334454-cqaado3u 77 28 system system NN cord-334454-cqaado3u 77 29 , , , cord-334454-cqaado3u 77 30 helping help VBG cord-334454-cqaado3u 77 31 to to TO cord-334454-cqaado3u 77 32 clarify clarify VB cord-334454-cqaado3u 77 33 the the DT cord-334454-cqaado3u 77 34 mechanisms mechanism NNS cord-334454-cqaado3u 77 35 of of IN cord-334454-cqaado3u 77 36 action action NN cord-334454-cqaado3u 77 37 of of IN cord-334454-cqaado3u 77 38 the the DT cord-334454-cqaado3u 77 39 licensed licensed JJ cord-334454-cqaado3u 77 40 protocol protocol NN cord-334454-cqaado3u 77 41 [ [ -LRB- cord-334454-cqaado3u 77 42 28 28 CD cord-334454-cqaado3u 77 43 ] ] -RRB- cord-334454-cqaado3u 77 44 . . . cord-334454-cqaado3u 78 1 In in IN cord-334454-cqaado3u 78 2 order order NN cord-334454-cqaado3u 78 3 to to TO cord-334454-cqaado3u 78 4 explore explore VB cord-334454-cqaado3u 78 5 in in IN cord-334454-cqaado3u 78 6 greater great JJR cord-334454-cqaado3u 78 7 detail detail NN cord-334454-cqaado3u 78 8 these these DT cord-334454-cqaado3u 78 9 conclusions conclusion NNS cord-334454-cqaado3u 78 10 , , , cord-334454-cqaado3u 78 11 the the DT cord-334454-cqaado3u 78 12 evaluation evaluation NN cord-334454-cqaado3u 78 13 of of IN cord-334454-cqaado3u 78 14 other other JJ cord-334454-cqaado3u 78 15 innate innate JJ cord-334454-cqaado3u 78 16 immunity immunity NN cord-334454-cqaado3u 78 17 biomarkers biomarker NNS cord-334454-cqaado3u 78 18 ( ( -LRB- cord-334454-cqaado3u 78 19 namely namely RB cord-334454-cqaado3u 78 20 Mx Mx NNP cord-334454-cqaado3u 78 21 protein protein NN cord-334454-cqaado3u 78 22 ) ) -RRB- cord-334454-cqaado3u 78 23 would would MD cord-334454-cqaado3u 78 24 be be VB cord-334454-cqaado3u 78 25 useful useful JJ cord-334454-cqaado3u 78 26 . . . cord-334454-cqaado3u 79 1 Although although IN cord-334454-cqaado3u 79 2 its -PRON- PRP$ cord-334454-cqaado3u 79 3 use use NN cord-334454-cqaado3u 79 4 in in IN cord-334454-cqaado3u 79 5 feline feline JJ cord-334454-cqaado3u 79 6 medicine medicine NN cord-334454-cqaado3u 79 7 is be VBZ cord-334454-cqaado3u 79 8 scarce scarce JJ cord-334454-cqaado3u 79 9 , , , cord-334454-cqaado3u 79 10 Mx Mx NNP cord-334454-cqaado3u 79 11 protein protein NN cord-334454-cqaado3u 79 12 is be VBZ cord-334454-cqaado3u 79 13 a a DT cord-334454-cqaado3u 79 14 specific specific JJ cord-334454-cqaado3u 79 15 type type NN cord-334454-cqaado3u 80 1 I -PRON- PRP cord-334454-cqaado3u 80 2 IFN IFN NNP cord-334454-cqaado3u 80 3 biomarker biomarker NN cord-334454-cqaado3u 80 4 [ [ -LRB- cord-334454-cqaado3u 80 5 8 8 CD cord-334454-cqaado3u 80 6 , , , cord-334454-cqaado3u 80 7 35 35 CD cord-334454-cqaado3u 80 8 ] ] -RRB- cord-334454-cqaado3u 80 9 ; ; : cord-334454-cqaado3u 81 1 hence hence RB cord-334454-cqaado3u 81 2 , , , cord-334454-cqaado3u 81 3 its -PRON- PRP$ cord-334454-cqaado3u 81 4 production production NN cord-334454-cqaado3u 81 5 is be VBZ cord-334454-cqaado3u 81 6 directly directly RB cord-334454-cqaado3u 81 7 related relate VBN cord-334454-cqaado3u 81 8 with with IN cord-334454-cqaado3u 81 9 the the DT cord-334454-cqaado3u 81 10 activation activation NN cord-334454-cqaado3u 81 11 of of IN cord-334454-cqaado3u 81 12 a a DT cord-334454-cqaado3u 81 13 type type NN cord-334454-cqaado3u 81 14 I -PRON- PRP cord-334454-cqaado3u 81 15 IFN IFN NNP cord-334454-cqaado3u 81 16 signal signal NN cord-334454-cqaado3u 81 17 transduction transduction NN cord-334454-cqaado3u 81 18 pathway pathway NN cord-334454-cqaado3u 81 19 . . . cord-334454-cqaado3u 82 1 In in IN cord-334454-cqaado3u 82 2 this this DT cord-334454-cqaado3u 82 3 sense sense NN cord-334454-cqaado3u 82 4 , , , cord-334454-cqaado3u 82 5 from from IN cord-334454-cqaado3u 82 6 the the DT cord-334454-cqaado3u 82 7 authors author NNS cord-334454-cqaado3u 82 8 ' ' POS cord-334454-cqaado3u 82 9 point point NN cord-334454-cqaado3u 82 10 of of IN cord-334454-cqaado3u 82 11 view view NN cord-334454-cqaado3u 82 12 , , , cord-334454-cqaado3u 82 13 further further JJ cord-334454-cqaado3u 82 14 studies study NNS cord-334454-cqaado3u 82 15 are be VBP cord-334454-cqaado3u 82 16 needed need VBN cord-334454-cqaado3u 82 17 to to TO cord-334454-cqaado3u 82 18 strengthen strengthen VB cord-334454-cqaado3u 82 19 these these DT cord-334454-cqaado3u 82 20 conclusions conclusion NNS cord-334454-cqaado3u 82 21 and and CC cord-334454-cqaado3u 82 22 to to TO cord-334454-cqaado3u 82 23 assess assess VB cord-334454-cqaado3u 82 24 whether whether IN cord-334454-cqaado3u 82 25 Mx Mx NNP cord-334454-cqaado3u 82 26 protein protein NN cord-334454-cqaado3u 82 27 can can MD cord-334454-cqaado3u 82 28 be be VB cord-334454-cqaado3u 82 29 a a DT cord-334454-cqaado3u 82 30 reasonable reasonable JJ cord-334454-cqaado3u 82 31 biomarker biomarker NN cord-334454-cqaado3u 82 32 of of IN cord-334454-cqaado3u 82 33 innate innate JJ cord-334454-cqaado3u 82 34 immunity immunity NN cord-334454-cqaado3u 82 35 in in IN cord-334454-cqaado3u 82 36 cats cat NNS cord-334454-cqaado3u 82 37 under under IN cord-334454-cqaado3u 82 38 rFeIFN rFeIFN NNP cord-334454-cqaado3u 82 39 - - HYPH cord-334454-cqaado3u 82 40 ω ω VBG cord-334454-cqaado3u 82 41 therapy therapy NN cord-334454-cqaado3u 82 42 . . . cord-334454-cqaado3u 83 1 Recognizing recognize VBG cord-334454-cqaado3u 83 2 that that IN cord-334454-cqaado3u 83 3 , , , cord-334454-cqaado3u 83 4 in in IN cord-334454-cqaado3u 83 5 clinical clinical JJ cord-334454-cqaado3u 83 6 practice practice NN cord-334454-cqaado3u 83 7 , , , cord-334454-cqaado3u 83 8 rFeIFN rfeifn NN cord-334454-cqaado3u 83 9 - - HYPH cord-334454-cqaado3u 83 10 ω ω NN cord-334454-cqaado3u 83 11 is be VBZ cord-334454-cqaado3u 83 12 very very RB cord-334454-cqaado3u 83 13 often often RB cord-334454-cqaado3u 83 14 a a DT cord-334454-cqaado3u 83 15 cost cost NN cord-334454-cqaado3u 83 16 - - HYPH cord-334454-cqaado3u 83 17 limiting limit VBG cord-334454-cqaado3u 83 18 therapy therapy NN cord-334454-cqaado3u 83 19 , , , cord-334454-cqaado3u 83 20 the the DT cord-334454-cqaado3u 83 21 use use NN cord-334454-cqaado3u 83 22 of of IN cord-334454-cqaado3u 83 23 an an DT cord-334454-cqaado3u 83 24 alternative alternative JJ cord-334454-cqaado3u 83 25 oral oral JJ cord-334454-cqaado3u 83 26 protocol protocol NN cord-334454-cqaado3u 83 27 in in IN cord-334454-cqaado3u 83 28 FIV FIV NNP cord-334454-cqaado3u 83 29 - - HYPH cord-334454-cqaado3u 83 30 infected infect VBN cord-334454-cqaado3u 83 31 cats cat NNS cord-334454-cqaado3u 83 32 has have VBZ cord-334454-cqaado3u 83 33 also also RB cord-334454-cqaado3u 83 34 been be VBN cord-334454-cqaado3u 83 35 documented document VBN cord-334454-cqaado3u 83 36 [ [ -LRB- cord-334454-cqaado3u 83 37 25 25 CD cord-334454-cqaado3u 83 38 ] ] -RRB- cord-334454-cqaado3u 83 39 . . . cord-334454-cqaado3u 84 1 In in IN cord-334454-cqaado3u 84 2 fact fact NN cord-334454-cqaado3u 84 3 , , , cord-334454-cqaado3u 84 4 different different JJ cord-334454-cqaado3u 84 5 authors author NNS cord-334454-cqaado3u 84 6 reported report VBD cord-334454-cqaado3u 84 7 the the DT cord-334454-cqaado3u 84 8 clinical clinical JJ cord-334454-cqaado3u 84 9 benefits benefit NNS cord-334454-cqaado3u 84 10 of of IN cord-334454-cqaado3u 84 11 oral oral JJ cord-334454-cqaado3u 84 12 low low JJ cord-334454-cqaado3u 84 13 dose dose NN cord-334454-cqaado3u 84 14 HuIFN HuIFN NNP cord-334454-cqaado3u 84 15 - - HYPH cord-334454-cqaado3u 84 16 α α NN cord-334454-cqaado3u 84 17 protocols protocol NNS cord-334454-cqaado3u 84 18 in in IN cord-334454-cqaado3u 84 19 viral viral JJ cord-334454-cqaado3u 84 20 infections infection NNS cord-334454-cqaado3u 84 21 such such JJ cord-334454-cqaado3u 84 22 as as IN cord-334454-cqaado3u 84 23 FIV FIV NNP cord-334454-cqaado3u 84 24 [ [ -LRB- cord-334454-cqaado3u 84 25 19 19 CD cord-334454-cqaado3u 84 26 , , , cord-334454-cqaado3u 84 27 21 21 CD cord-334454-cqaado3u 84 28 ] ] -RRB- cord-334454-cqaado3u 84 29 . . . cord-334454-cqaado3u 85 1 After after IN cord-334454-cqaado3u 85 2 the the DT cord-334454-cqaado3u 85 3 release release NN cord-334454-cqaado3u 85 4 of of IN cord-334454-cqaado3u 85 5 rFeIFN rfeifn NN cord-334454-cqaado3u 85 6 - - HYPH cord-334454-cqaado3u 85 7 ω ω JJS cord-334454-cqaado3u 85 8 , , , cord-334454-cqaado3u 85 9 several several JJ cord-334454-cqaado3u 85 10 clinical clinical JJ cord-334454-cqaado3u 85 11 trials trial NNS cord-334454-cqaado3u 85 12 had have VBD cord-334454-cqaado3u 85 13 also also RB cord-334454-cqaado3u 85 14 been be VBN cord-334454-cqaado3u 85 15 conducted conduct VBN cord-334454-cqaado3u 85 16 in in IN cord-334454-cqaado3u 85 17 specific specific JJ cord-334454-cqaado3u 85 18 - - HYPH cord-334454-cqaado3u 85 19 pathogen pathogen NN cord-334454-cqaado3u 85 20 free free JJ cord-334454-cqaado3u 85 21 cats cat NNS cord-334454-cqaado3u 85 22 and and CC cord-334454-cqaado3u 85 23 calicivirus calicivirus JJ cord-334454-cqaado3u 85 24 - - HYPH cord-334454-cqaado3u 85 25 positive positive JJ cord-334454-cqaado3u 85 26 cats cat NNS cord-334454-cqaado3u 85 27 in in IN cord-334454-cqaado3u 85 28 order order NN cord-334454-cqaado3u 85 29 to to TO cord-334454-cqaado3u 85 30 study study VB cord-334454-cqaado3u 85 31 the the DT cord-334454-cqaado3u 85 32 immune immune JJ cord-334454-cqaado3u 85 33 - - HYPH cord-334454-cqaado3u 85 34 modulation modulation NN cord-334454-cqaado3u 85 35 properties property NNS cord-334454-cqaado3u 85 36 of of IN cord-334454-cqaado3u 85 37 oral oral JJ cord-334454-cqaado3u 85 38 rFeIFN rfeifn NN cord-334454-cqaado3u 85 39 - - HYPH cord-334454-cqaado3u 85 40 ω ω VBG cord-334454-cqaado3u 85 41 [ [ -LRB- cord-334454-cqaado3u 85 42 8 8 CD cord-334454-cqaado3u 85 43 , , , cord-334454-cqaado3u 85 44 36 36 CD cord-334454-cqaado3u 85 45 ] ] -RRB- cord-334454-cqaado3u 85 46 . . . cord-334454-cqaado3u 86 1 However however RB cord-334454-cqaado3u 86 2 , , , cord-334454-cqaado3u 86 3 no no DT cord-334454-cqaado3u 86 4 studies study NNS cord-334454-cqaado3u 86 5 have have VBP cord-334454-cqaado3u 86 6 documented document VBN cord-334454-cqaado3u 86 7 its -PRON- PRP$ cord-334454-cqaado3u 86 8 use use NN cord-334454-cqaado3u 86 9 in in IN cord-334454-cqaado3u 86 10 retrovirally retrovirally NN cord-334454-cqaado3u 86 11 infected infected JJ cord-334454-cqaado3u 86 12 cats cat NNS cord-334454-cqaado3u 86 13 , , , cord-334454-cqaado3u 86 14 particularly particularly RB cord-334454-cqaado3u 86 15 in in IN cord-334454-cqaado3u 86 16 FIV fiv NN cord-334454-cqaado3u 86 17 - - HYPH cord-334454-cqaado3u 86 18 infected infect VBN cord-334454-cqaado3u 86 19 ones one NNS cord-334454-cqaado3u 86 20 . . . cord-334454-cqaado3u 87 1 In in IN cord-334454-cqaado3u 87 2 this this DT cord-334454-cqaado3u 87 3 sense sense NN cord-334454-cqaado3u 87 4 , , , cord-334454-cqaado3u 87 5 an an DT cord-334454-cqaado3u 87 6 oral oral JJ cord-334454-cqaado3u 87 7 rFeIFN rfeifn NN cord-334454-cqaado3u 87 8 - - HYPH cord-334454-cqaado3u 87 9 ω ω CD cord-334454-cqaado3u 87 10 protocol protocol NN cord-334454-cqaado3u 87 11 was be VBD cord-334454-cqaado3u 87 12 developed develop VBN cord-334454-cqaado3u 87 13 and and CC cord-334454-cqaado3u 87 14 administered administer VBN cord-334454-cqaado3u 87 15 to to IN cord-334454-cqaado3u 87 16 11 11 CD cord-334454-cqaado3u 87 17 client client NN cord-334454-cqaado3u 87 18 - - HYPH cord-334454-cqaado3u 87 19 owned own VBN cord-334454-cqaado3u 87 20 FIV FIV NNP cord-334454-cqaado3u 87 21 - - HYPH cord-334454-cqaado3u 87 22 infected infect VBN cord-334454-cqaado3u 87 23 cats cat NNS cord-334454-cqaado3u 87 24 [ [ -LRB- cord-334454-cqaado3u 87 25 25 25 CD cord-334454-cqaado3u 87 26 ] ] -RRB- cord-334454-cqaado3u 87 27 . . . cord-334454-cqaado3u 88 1 The the DT cord-334454-cqaado3u 88 2 oral oral JJ cord-334454-cqaado3u 88 3 dose dose NN cord-334454-cqaado3u 88 4 was be VBD cord-334454-cqaado3u 88 5 based base VBN cord-334454-cqaado3u 88 6 on on IN cord-334454-cqaado3u 88 7 the the DT cord-334454-cqaado3u 88 8 referred refer VBN cord-334454-cqaado3u 88 9 previous previous JJ cord-334454-cqaado3u 88 10 studies study NNS cord-334454-cqaado3u 88 11 and and CC cord-334454-cqaado3u 88 12 was be VBD cord-334454-cqaado3u 88 13 decided decide VBN cord-334454-cqaado3u 88 14 according accord VBG cord-334454-cqaado3u 88 15 to to IN cord-334454-cqaado3u 88 16 the the DT cord-334454-cqaado3u 88 17 manufacturer manufacturer NN cord-334454-cqaado3u 88 18 's 's POS cord-334454-cqaado3u 88 19 previous previous JJ cord-334454-cqaado3u 88 20 trials trial NNS cord-334454-cqaado3u 88 21 [ [ -LRB- cord-334454-cqaado3u 88 22 8 8 CD cord-334454-cqaado3u 88 23 , , , cord-334454-cqaado3u 88 24 36 36 CD cord-334454-cqaado3u 88 25 ] ] -RRB- cord-334454-cqaado3u 88 26 . . . cord-334454-cqaado3u 89 1 The the DT cord-334454-cqaado3u 89 2 oral oral JJ cord-334454-cqaado3u 89 3 protocol protocol NN cord-334454-cqaado3u 89 4 was be VBD cord-334454-cqaado3u 89 5 10-fold 10-fold JJ cord-334454-cqaado3u 89 6 lower low JJR cord-334454-cqaado3u 89 7 that that IN cord-334454-cqaado3u 89 8 the the DT cord-334454-cqaado3u 89 9 licensed licensed JJ cord-334454-cqaado3u 89 10 subcutaneous subcutaneous JJ cord-334454-cqaado3u 89 11 protocol protocol NN cord-334454-cqaado3u 89 12 , , , cord-334454-cqaado3u 89 13 and and CC cord-334454-cqaado3u 89 14 it -PRON- PRP cord-334454-cqaado3u 89 15 was be VBD cord-334454-cqaado3u 89 16 given give VBN cord-334454-cqaado3u 89 17 orally orally RB cord-334454-cqaado3u 89 18 instead instead RB cord-334454-cqaado3u 89 19 of of IN cord-334454-cqaado3u 89 20 subcutaneously subcutaneously RB cord-334454-cqaado3u 89 21 and and CC cord-334454-cqaado3u 89 22 for for IN cord-334454-cqaado3u 89 23 a a DT cord-334454-cqaado3u 89 24 longer long JJR cord-334454-cqaado3u 89 25 period period NN cord-334454-cqaado3u 89 26 of of IN cord-334454-cqaado3u 89 27 time time NN cord-334454-cqaado3u 89 28 ( ( -LRB- cord-334454-cqaado3u 89 29 90 90 CD cord-334454-cqaado3u 89 30 continuous continuous JJ cord-334454-cqaado3u 89 31 days day NNS cord-334454-cqaado3u 89 32 ) ) -RRB- cord-334454-cqaado3u 89 33 . . . cord-334454-cqaado3u 90 1 Following follow VBG cord-334454-cqaado3u 90 2 the the DT cord-334454-cqaado3u 90 3 same same JJ cord-334454-cqaado3u 90 4 methodology methodology NN cord-334454-cqaado3u 90 5 of of IN cord-334454-cqaado3u 90 6 previous previous JJ cord-334454-cqaado3u 90 7 studies study NNS cord-334454-cqaado3u 90 8 , , , cord-334454-cqaado3u 90 9 the the DT cord-334454-cqaado3u 90 10 clinical clinical JJ cord-334454-cqaado3u 90 11 improvement improvement NN cord-334454-cqaado3u 90 12 , , , cord-334454-cqaado3u 90 13 concurrent concurrent JJ cord-334454-cqaado3u 90 14 viral viral JJ cord-334454-cqaado3u 90 15 excretion excretion NN cord-334454-cqaado3u 90 16 , , , cord-334454-cqaado3u 90 17 APP app NN cord-334454-cqaado3u 90 18 profiles profile NNS cord-334454-cqaado3u 90 19 , , , cord-334454-cqaado3u 90 20 and and CC cord-334454-cqaado3u 90 21 different different JJ cord-334454-cqaado3u 90 22 hematology hematology NN cord-334454-cqaado3u 90 23 and and CC cord-334454-cqaado3u 90 24 biochemistry biochemistry NN cord-334454-cqaado3u 90 25 parameters parameter NNS cord-334454-cqaado3u 90 26 in in IN cord-334454-cqaado3u 90 27 FIV fiv NN cord-334454-cqaado3u 90 28 - - HYPH cord-334454-cqaado3u 90 29 infected infect VBN cord-334454-cqaado3u 90 30 cats cat NNS cord-334454-cqaado3u 90 31 treated treat VBN cord-334454-cqaado3u 90 32 with with IN cord-334454-cqaado3u 90 33 the the DT cord-334454-cqaado3u 90 34 oral oral JJ cord-334454-cqaado3u 90 35 protocol protocol NN cord-334454-cqaado3u 90 36 were be VBD cord-334454-cqaado3u 90 37 assessed assess VBN cord-334454-cqaado3u 90 38 . . . cord-334454-cqaado3u 91 1 Similarly similarly RB cord-334454-cqaado3u 91 2 to to IN cord-334454-cqaado3u 91 3 what what WP cord-334454-cqaado3u 91 4 was be VBD cord-334454-cqaado3u 91 5 observed observe VBN cord-334454-cqaado3u 91 6 for for IN cord-334454-cqaado3u 91 7 the the DT cord-334454-cqaado3u 91 8 licensed licensed JJ cord-334454-cqaado3u 91 9 protocol protocol NN cord-334454-cqaado3u 91 10 , , , cord-334454-cqaado3u 91 11 cats cat NNS cord-334454-cqaado3u 91 12 treated treat VBN cord-334454-cqaado3u 91 13 with with IN cord-334454-cqaado3u 91 14 oral oral JJ cord-334454-cqaado3u 91 15 rFeIFN rfeifn NN cord-334454-cqaado3u 91 16 - - HYPH cord-334454-cqaado3u 91 17 ω ω JJ cord-334454-cqaado3u 92 1 showed show VBD cord-334454-cqaado3u 92 2 a a DT cord-334454-cqaado3u 92 3 significant significant JJ cord-334454-cqaado3u 92 4 clinical clinical JJ cord-334454-cqaado3u 92 5 improvement improvement NN cord-334454-cqaado3u 92 6 without without IN cord-334454-cqaado3u 92 7 remarkable remarkable JJ cord-334454-cqaado3u 92 8 changes change NNS cord-334454-cqaado3u 92 9 in in IN cord-334454-cqaado3u 92 10 hematology hematology NN cord-334454-cqaado3u 92 11 and and CC cord-334454-cqaado3u 92 12 biochemistry biochemistry NN cord-334454-cqaado3u 92 13 profiles profile NNS cord-334454-cqaado3u 92 14 , , , cord-334454-cqaado3u 92 15 which which WDT cord-334454-cqaado3u 92 16 were be VBD cord-334454-cqaado3u 92 17 within within IN cord-334454-cqaado3u 92 18 the the DT cord-334454-cqaado3u 92 19 reference reference NN cord-334454-cqaado3u 92 20 range range NN cord-334454-cqaado3u 92 21 in in IN cord-334454-cqaado3u 92 22 the the DT cord-334454-cqaado3u 92 23 majority majority NN cord-334454-cqaado3u 92 24 of of IN cord-334454-cqaado3u 92 25 the the DT cord-334454-cqaado3u 92 26 treated treat VBN cord-334454-cqaado3u 92 27 cats cat NNS cord-334454-cqaado3u 92 28 [ [ -LRB- cord-334454-cqaado3u 92 29 25 25 CD cord-334454-cqaado3u 92 30 ] ] -RRB- cord-334454-cqaado3u 92 31 . . . cord-334454-cqaado3u 93 1 Conversely conversely RB cord-334454-cqaado3u 93 2 , , , cord-334454-cqaado3u 93 3 mainly mainly RB cord-334454-cqaado3u 93 4 due due IN cord-334454-cqaado3u 93 5 to to IN cord-334454-cqaado3u 93 6 the the DT cord-334454-cqaado3u 93 7 fact fact NN cord-334454-cqaado3u 93 8 that that IN cord-334454-cqaado3u 93 9 client client NN cord-334454-cqaado3u 93 10 - - HYPH cord-334454-cqaado3u 93 11 owned own VBN cord-334454-cqaado3u 93 12 cats cat NNS cord-334454-cqaado3u 93 13 were be VBD cord-334454-cqaado3u 93 14 less less RBR cord-334454-cqaado3u 93 15 prone prone JJ cord-334454-cqaado3u 93 16 to to IN cord-334454-cqaado3u 93 17 opportunistic opportunistic JJ cord-334454-cqaado3u 93 18 infections infection NNS cord-334454-cqaado3u 93 19 , , , cord-334454-cqaado3u 93 20 concurrent concurrent JJ cord-334454-cqaado3u 93 21 viral viral JJ cord-334454-cqaado3u 93 22 excretion excretion NN cord-334454-cqaado3u 93 23 was be VBD cord-334454-cqaado3u 93 24 very very RB cord-334454-cqaado3u 93 25 low low JJ cord-334454-cqaado3u 93 26 and and CC cord-334454-cqaado3u 93 27 did do VBD cord-334454-cqaado3u 93 28 not not RB cord-334454-cqaado3u 93 29 change change VB cord-334454-cqaado3u 93 30 with with IN cord-334454-cqaado3u 93 31 the the DT cord-334454-cqaado3u 93 32 applied apply VBN cord-334454-cqaado3u 93 33 protocol protocol NN cord-334454-cqaado3u 93 34 . . . cord-334454-cqaado3u 94 1 Additionally additionally RB cord-334454-cqaado3u 94 2 , , , cord-334454-cqaado3u 94 3 APP app NN cord-334454-cqaado3u 94 4 profiles profile NNS cord-334454-cqaado3u 94 5 did do VBD cord-334454-cqaado3u 94 6 not not RB cord-334454-cqaado3u 94 7 change change VB cord-334454-cqaado3u 94 8 in in IN cord-334454-cqaado3u 94 9 cats cat NNS cord-334454-cqaado3u 94 10 treated treat VBN cord-334454-cqaado3u 94 11 with with IN cord-334454-cqaado3u 94 12 oral oral JJ cord-334454-cqaado3u 94 13 rFeIFN rfeifn NN cord-334454-cqaado3u 94 14 - - HYPH cord-334454-cqaado3u 94 15 ω ω JJS cord-334454-cqaado3u 94 16 , , , cord-334454-cqaado3u 94 17 meaning mean VBG cord-334454-cqaado3u 94 18 that that IN cord-334454-cqaado3u 94 19 the the DT cord-334454-cqaado3u 94 20 two two CD cord-334454-cqaado3u 94 21 distinct distinct JJ cord-334454-cqaado3u 94 22 protocols protocol NNS cord-334454-cqaado3u 94 23 seem seem VBP cord-334454-cqaado3u 94 24 to to TO cord-334454-cqaado3u 94 25 act act VB cord-334454-cqaado3u 94 26 differently differently RB cord-334454-cqaado3u 94 27 . . . cord-334454-cqaado3u 95 1 Taking take VBG cord-334454-cqaado3u 95 2 APPs app NNS cord-334454-cqaado3u 95 3 as as IN cord-334454-cqaado3u 95 4 biomarkers biomarker NNS cord-334454-cqaado3u 95 5 of of IN cord-334454-cqaado3u 95 6 the the DT cord-334454-cqaado3u 95 7 innate innate JJ cord-334454-cqaado3u 95 8 immune immune JJ cord-334454-cqaado3u 95 9 response response NN cord-334454-cqaado3u 95 10 , , , cord-334454-cqaado3u 95 11 it -PRON- PRP cord-334454-cqaado3u 95 12 seems seem VBZ cord-334454-cqaado3u 95 13 reasonable reasonable JJ cord-334454-cqaado3u 95 14 to to TO cord-334454-cqaado3u 95 15 say say VB cord-334454-cqaado3u 95 16 that that IN cord-334454-cqaado3u 95 17 innate innate JJ cord-334454-cqaado3u 95 18 immune immune JJ cord-334454-cqaado3u 95 19 reaction reaction NN cord-334454-cqaado3u 95 20 does do VBZ cord-334454-cqaado3u 95 21 not not RB cord-334454-cqaado3u 95 22 seem seem VB cord-334454-cqaado3u 95 23 to to TO cord-334454-cqaado3u 95 24 be be VB cord-334454-cqaado3u 95 25 potentiated potentiate VBN cord-334454-cqaado3u 95 26 in in IN cord-334454-cqaado3u 95 27 the the DT cord-334454-cqaado3u 95 28 same same JJ cord-334454-cqaado3u 95 29 way way NN cord-334454-cqaado3u 95 30 as as IN cord-334454-cqaado3u 95 31 observed observe VBN cord-334454-cqaado3u 95 32 in in IN cord-334454-cqaado3u 95 33 the the DT cord-334454-cqaado3u 95 34 licensed licensed JJ cord-334454-cqaado3u 95 35 protocol protocol NN cord-334454-cqaado3u 95 36 . . . cord-334454-cqaado3u 96 1 However however RB cord-334454-cqaado3u 96 2 , , , cord-334454-cqaado3u 96 3 as as IN cord-334454-cqaado3u 96 4 interferons interferon NNS cord-334454-cqaado3u 96 5 have have VBP cord-334454-cqaado3u 96 6 pleotropic pleotropic JJ cord-334454-cqaado3u 96 7 effects effect NNS cord-334454-cqaado3u 96 8 and and CC cord-334454-cqaado3u 96 9 APPs app NNS cord-334454-cqaado3u 96 10 are be VBP cord-334454-cqaado3u 96 11 only only RB cord-334454-cqaado3u 96 12 a a DT cord-334454-cqaado3u 96 13 part part NN cord-334454-cqaado3u 96 14 of of IN cord-334454-cqaado3u 96 15 the the DT cord-334454-cqaado3u 96 16 innate innate JJ cord-334454-cqaado3u 96 17 immune immune JJ cord-334454-cqaado3u 96 18 response response NN cord-334454-cqaado3u 96 19 , , , cord-334454-cqaado3u 96 20 it -PRON- PRP cord-334454-cqaado3u 96 21 is be VBZ cord-334454-cqaado3u 96 22 overspeculative overspeculative VBN cord-334454-cqaado3u 96 23 to to TO cord-334454-cqaado3u 96 24 assume assume VB cord-334454-cqaado3u 96 25 that that IN cord-334454-cqaado3u 96 26 oral oral JJ cord-334454-cqaado3u 96 27 rFeIFN rfeifn NN cord-334454-cqaado3u 96 28 - - HYPH cord-334454-cqaado3u 96 29 ω ω NN cord-334454-cqaado3u 96 30 does do VBZ cord-334454-cqaado3u 96 31 not not RB cord-334454-cqaado3u 96 32 interfere interfere VB cord-334454-cqaado3u 96 33 with with IN cord-334454-cqaado3u 96 34 innate innate JJ cord-334454-cqaado3u 96 35 immunity immunity NN cord-334454-cqaado3u 96 36 . . . cord-334454-cqaado3u 97 1 Even even RB cord-334454-cqaado3u 97 2 if if IN cord-334454-cqaado3u 97 3 APPs app NNS cord-334454-cqaado3u 97 4 did do VBD cord-334454-cqaado3u 97 5 not not RB cord-334454-cqaado3u 97 6 change change VB cord-334454-cqaado3u 97 7 , , , cord-334454-cqaado3u 97 8 overall overall JJ cord-334454-cqaado3u 97 9 results result NNS cord-334454-cqaado3u 97 10 showed show VBD cord-334454-cqaado3u 97 11 an an DT cord-334454-cqaado3u 97 12 important important JJ cord-334454-cqaado3u 97 13 clinical clinical JJ cord-334454-cqaado3u 97 14 improvement improvement NN cord-334454-cqaado3u 97 15 and and CC cord-334454-cqaado3u 97 16 reinforced reinforce VBD cord-334454-cqaado3u 97 17 the the DT cord-334454-cqaado3u 97 18 potential potential JJ cord-334454-cqaado3u 97 19 extra extra JJ cord-334454-cqaado3u 97 20 - - JJ cord-334454-cqaado3u 97 21 label label JJ cord-334454-cqaado3u 97 22 use use NN cord-334454-cqaado3u 97 23 of of IN cord-334454-cqaado3u 97 24 rFeIFN rFeIFN NNP cord-334454-cqaado3u 97 25 - - HYPH cord-334454-cqaado3u 97 26 ω ω JJ cord-334454-cqaado3u 97 27 in in IN cord-334454-cqaado3u 97 28 an an DT cord-334454-cqaado3u 97 29 oral oral JJ cord-334454-cqaado3u 97 30 continuous continuous JJ cord-334454-cqaado3u 97 31 low low JJ cord-334454-cqaado3u 97 32 - - HYPH cord-334454-cqaado3u 97 33 dose dose NN cord-334454-cqaado3u 97 34 protocol protocol NN cord-334454-cqaado3u 97 35 . . . cord-334454-cqaado3u 98 1 For for IN cord-334454-cqaado3u 98 2 a a DT cord-334454-cqaado3u 98 3 second second JJ cord-334454-cqaado3u 98 4 time time NN cord-334454-cqaado3u 98 5 , , , cord-334454-cqaado3u 98 6 the the DT cord-334454-cqaado3u 98 7 effect effect NN cord-334454-cqaado3u 98 8 of of IN cord-334454-cqaado3u 98 9 both both DT cord-334454-cqaado3u 98 10 protocols protocol NNS cord-334454-cqaado3u 98 11 of of IN cord-334454-cqaado3u 98 12 rFeIFN rfeifn NN cord-334454-cqaado3u 98 13 - - HYPH cord-334454-cqaado3u 98 14 ω ω JJ cord-334454-cqaado3u 98 15 on on IN cord-334454-cqaado3u 98 16 cytokine cytokine NN cord-334454-cqaado3u 98 17 profile profile NN cord-334454-cqaado3u 98 18 , , , cord-334454-cqaado3u 98 19 viremia viremia NN cord-334454-cqaado3u 98 20 , , , cord-334454-cqaado3u 98 21 and and CC cord-334454-cqaado3u 98 22 proviral proviral NNP cord-334454-cqaado3u 98 23 load load NNP cord-334454-cqaado3u 98 24 was be VBD cord-334454-cqaado3u 98 25 evaluated evaluate VBN cord-334454-cqaado3u 98 26 [ [ -LRB- cord-334454-cqaado3u 98 27 27 27 CD cord-334454-cqaado3u 98 28 ] ] -RRB- cord-334454-cqaado3u 98 29 . . . cord-334454-cqaado3u 99 1 Only only RB cord-334454-cqaado3u 99 2 one one CD cord-334454-cqaado3u 99 3 study study NN cord-334454-cqaado3u 99 4 had have VBD cord-334454-cqaado3u 99 5 previously previously RB cord-334454-cqaado3u 99 6 reported report VBN cord-334454-cqaado3u 99 7 that that IN cord-334454-cqaado3u 99 8 the the DT cord-334454-cqaado3u 99 9 licensed licensed JJ cord-334454-cqaado3u 99 10 protocol protocol NN cord-334454-cqaado3u 99 11 does do VBZ cord-334454-cqaado3u 99 12 not not RB cord-334454-cqaado3u 99 13 change change VB cord-334454-cqaado3u 99 14 viremia viremia NN cord-334454-cqaado3u 99 15 or or CC cord-334454-cqaado3u 99 16 proviral proviral JJ cord-334454-cqaado3u 99 17 load load NN cord-334454-cqaado3u 99 18 in in IN cord-334454-cqaado3u 99 19 treated treat VBN cord-334454-cqaado3u 99 20 FIV fiv NN cord-334454-cqaado3u 99 21 - - HYPH cord-334454-cqaado3u 99 22 infected infect VBN cord-334454-cqaado3u 99 23 cats cat NNS cord-334454-cqaado3u 99 24 , , , cord-334454-cqaado3u 99 25 suggesting suggest VBG cord-334454-cqaado3u 99 26 that that IN cord-334454-cqaado3u 99 27 this this DT cord-334454-cqaado3u 99 28 compound compound NN cord-334454-cqaado3u 99 29 may may MD cord-334454-cqaado3u 99 30 not not RB cord-334454-cqaado3u 99 31 act act VB cord-334454-cqaado3u 99 32 on on IN cord-334454-cqaado3u 99 33 acquired acquire VBN cord-334454-cqaado3u 99 34 immunity immunity NN cord-334454-cqaado3u 99 35 [ [ -LRB- cord-334454-cqaado3u 99 36 17 17 CD cord-334454-cqaado3u 99 37 ] ] -RRB- cord-334454-cqaado3u 99 38 . . . cord-334454-cqaado3u 100 1 In in IN cord-334454-cqaado3u 100 2 agreement agreement NN cord-334454-cqaado3u 100 3 with with IN cord-334454-cqaado3u 100 4 these these DT cord-334454-cqaado3u 100 5 results result NNS cord-334454-cqaado3u 100 6 , , , cord-334454-cqaado3u 100 7 authors author NNS cord-334454-cqaado3u 100 8 concluded conclude VBD cord-334454-cqaado3u 100 9 that that IN cord-334454-cqaado3u 100 10 viremia viremia NN cord-334454-cqaado3u 100 11 did do VBD cord-334454-cqaado3u 100 12 not not RB cord-334454-cqaado3u 100 13 change change VB cord-334454-cqaado3u 100 14 in in IN cord-334454-cqaado3u 100 15 the the DT cord-334454-cqaado3u 100 16 group group NN cord-334454-cqaado3u 100 17 of of IN cord-334454-cqaado3u 100 18 FIV FIV NNP cord-334454-cqaado3u 100 19 - - HYPH cord-334454-cqaado3u 100 20 infected infect VBN cord-334454-cqaado3u 100 21 cats cat NNS cord-334454-cqaado3u 100 22 treated treat VBN cord-334454-cqaado3u 100 23 with with IN cord-334454-cqaado3u 100 24 the the DT cord-334454-cqaado3u 100 25 licensed licensed JJ cord-334454-cqaado3u 100 26 protocol protocol NN cord-334454-cqaado3u 100 27 [ [ -LRB- cord-334454-cqaado3u 100 28 27 27 CD cord-334454-cqaado3u 100 29 ] ] -RRB- cord-334454-cqaado3u 100 30 . . . cord-334454-cqaado3u 101 1 However however RB cord-334454-cqaado3u 101 2 , , , cord-334454-cqaado3u 101 3 in in IN cord-334454-cqaado3u 101 4 opposition opposition NN cord-334454-cqaado3u 101 5 to to IN cord-334454-cqaado3u 101 6 what what WP cord-334454-cqaado3u 101 7 was be VBD cord-334454-cqaado3u 101 8 previously previously RB cord-334454-cqaado3u 101 9 reported report VBN cord-334454-cqaado3u 101 10 , , , cord-334454-cqaado3u 101 11 a a DT cord-334454-cqaado3u 101 12 significant significant JJ cord-334454-cqaado3u 101 13 increase increase NN cord-334454-cqaado3u 101 14 on on IN cord-334454-cqaado3u 101 15 proviral proviral JJ cord-334454-cqaado3u 101 16 load load NN cord-334454-cqaado3u 101 17 was be VBD cord-334454-cqaado3u 101 18 reported report VBN cord-334454-cqaado3u 101 19 and and CC cord-334454-cqaado3u 101 20 correlated correlate VBN cord-334454-cqaado3u 101 21 to to IN cord-334454-cqaado3u 101 22 a a DT cord-334454-cqaado3u 101 23 relative relative JJ cord-334454-cqaado3u 101 24 increase increase NN cord-334454-cqaado3u 101 25 of of IN cord-334454-cqaado3u 101 26 lymphocytes lymphocyte NNS cord-334454-cqaado3u 101 27 cell cell NN cord-334454-cqaado3u 101 28 count count NN cord-334454-cqaado3u 101 29 ( ( -LRB- cord-334454-cqaado3u 101 30 even even RB cord-334454-cqaado3u 101 31 within within IN cord-334454-cqaado3u 101 32 the the DT cord-334454-cqaado3u 101 33 normal normal JJ cord-334454-cqaado3u 101 34 range range NN cord-334454-cqaado3u 101 35 ) ) -RRB- cord-334454-cqaado3u 102 1 [ [ -LRB- cord-334454-cqaado3u 102 2 27 27 CD cord-334454-cqaado3u 102 3 ] ] -RRB- cord-334454-cqaado3u 102 4 . . . cord-334454-cqaado3u 103 1 In in IN cord-334454-cqaado3u 103 2 this this DT cord-334454-cqaado3u 103 3 study study NN cord-334454-cqaado3u 103 4 , , , cord-334454-cqaado3u 103 5 viremia viremia NNP cord-334454-cqaado3u 103 6 and and CC cord-334454-cqaado3u 103 7 proviral proviral JJ cord-334454-cqaado3u 103 8 load load NN cord-334454-cqaado3u 103 9 changes change NNS cord-334454-cqaado3u 103 10 in in IN cord-334454-cqaado3u 103 11 FIV FIV NNP cord-334454-cqaado3u 103 12 - - HYPH cord-334454-cqaado3u 103 13 infected infect VBN cord-334454-cqaado3u 103 14 cats cat NNS cord-334454-cqaado3u 103 15 treated treat VBN cord-334454-cqaado3u 103 16 with with IN cord-334454-cqaado3u 103 17 oral oral JJ cord-334454-cqaado3u 103 18 rFeIFN rfeifn NN cord-334454-cqaado3u 103 19 - - HYPH cord-334454-cqaado3u 103 20 ω ω NN cord-334454-cqaado3u 103 21 were be VBD cord-334454-cqaado3u 103 22 also also RB cord-334454-cqaado3u 103 23 evaluated evaluate VBN cord-334454-cqaado3u 103 24 . . . cord-334454-cqaado3u 104 1 As as IN cord-334454-cqaado3u 104 2 expected expect VBN cord-334454-cqaado3u 104 3 , , , cord-334454-cqaado3u 104 4 no no DT cord-334454-cqaado3u 104 5 changes change NNS cord-334454-cqaado3u 104 6 were be VBD cord-334454-cqaado3u 104 7 obtained obtain VBN cord-334454-cqaado3u 104 8 in in IN cord-334454-cqaado3u 104 9 either either DT cord-334454-cqaado3u 104 10 parameter parameter NN cord-334454-cqaado3u 104 11 , , , cord-334454-cqaado3u 104 12 which which WDT cord-334454-cqaado3u 104 13 reinforced reinforce VBD cord-334454-cqaado3u 104 14 the the DT cord-334454-cqaado3u 104 15 previous previous JJ cord-334454-cqaado3u 104 16 suggestion suggestion NN cord-334454-cqaado3u 104 17 that that IN cord-334454-cqaado3u 104 18 , , , cord-334454-cqaado3u 104 19 independently independently RB cord-334454-cqaado3u 104 20 of of IN cord-334454-cqaado3u 104 21 the the DT cord-334454-cqaado3u 104 22 administered administer VBN cord-334454-cqaado3u 104 23 protocol protocol NN cord-334454-cqaado3u 104 24 , , , cord-334454-cqaado3u 104 25 the the DT cord-334454-cqaado3u 104 26 rFeIFN rFeIFN NNP cord-334454-cqaado3u 104 27 - - HYPH cord-334454-cqaado3u 104 28 ω ω NNP cord-334454-cqaado3u 104 29 's 's POS cord-334454-cqaado3u 104 30 anti anti JJ cord-334454-cqaado3u 104 31 - - JJ cord-334454-cqaado3u 104 32 viral viral JJ cord-334454-cqaado3u 104 33 effect effect NN cord-334454-cqaado3u 104 34 in in IN cord-334454-cqaado3u 104 35 vivo vivo NN cord-334454-cqaado3u 104 36 is be VBZ cord-334454-cqaado3u 104 37 negligible negligible JJ cord-334454-cqaado3u 104 38 . . . cord-334454-cqaado3u 105 1 At at IN cord-334454-cqaado3u 105 2 this this DT cord-334454-cqaado3u 105 3 point point NN cord-334454-cqaado3u 105 4 , , , cord-334454-cqaado3u 105 5 it -PRON- PRP cord-334454-cqaado3u 105 6 was be VBD cord-334454-cqaado3u 105 7 concluded conclude VBN cord-334454-cqaado3u 105 8 that that IN cord-334454-cqaado3u 105 9 rFeIFN rfeifn NN cord-334454-cqaado3u 105 10 - - HYPH cord-334454-cqaado3u 105 11 ω ω CD cord-334454-cqaado3u 105 12 licensed licensed JJ cord-334454-cqaado3u 105 13 protocol protocol NN cord-334454-cqaado3u 105 14 induced induce VBD cord-334454-cqaado3u 105 15 a a DT cord-334454-cqaado3u 105 16 decrease decrease NN cord-334454-cqaado3u 105 17 in in IN cord-334454-cqaado3u 105 18 concurrent concurrent JJ cord-334454-cqaado3u 105 19 viral viral JJ cord-334454-cqaado3u 105 20 infections infection NNS cord-334454-cqaado3u 105 21 , , , cord-334454-cqaado3u 105 22 even even RB cord-334454-cqaado3u 105 23 if if IN cord-334454-cqaado3u 105 24 there there EX cord-334454-cqaado3u 105 25 were be VBD cord-334454-cqaado3u 105 26 no no DT cord-334454-cqaado3u 105 27 true true JJ cord-334454-cqaado3u 105 28 changes change NNS cord-334454-cqaado3u 105 29 in in IN cord-334454-cqaado3u 105 30 FIV FIV NNP cord-334454-cqaado3u 105 31 viral viral JJ cord-334454-cqaado3u 105 32 load load NN cord-334454-cqaado3u 105 33 . . . cord-334454-cqaado3u 106 1 On on IN cord-334454-cqaado3u 106 2 the the DT cord-334454-cqaado3u 106 3 other other JJ cord-334454-cqaado3u 106 4 hand hand NN cord-334454-cqaado3u 106 5 , , , cord-334454-cqaado3u 106 6 in in IN cord-334454-cqaado3u 106 7 the the DT cord-334454-cqaado3u 106 8 oral oral JJ cord-334454-cqaado3u 106 9 protocol protocol NN cord-334454-cqaado3u 106 10 , , , cord-334454-cqaado3u 106 11 albeit albeit IN cord-334454-cqaado3u 106 12 no no DT cord-334454-cqaado3u 106 13 changes change NNS cord-334454-cqaado3u 106 14 on on IN cord-334454-cqaado3u 106 15 the the DT cord-334454-cqaado3u 106 16 viral viral JJ cord-334454-cqaado3u 106 17 load load NN cord-334454-cqaado3u 106 18 and and CC cord-334454-cqaado3u 106 19 concurrent concurrent JJ cord-334454-cqaado3u 106 20 viral viral JJ cord-334454-cqaado3u 106 21 infections infection NNS cord-334454-cqaado3u 106 22 , , , cord-334454-cqaado3u 106 23 there there EX cord-334454-cqaado3u 106 24 was be VBD cord-334454-cqaado3u 106 25 a a DT cord-334454-cqaado3u 106 26 significant significant JJ cord-334454-cqaado3u 106 27 clinical clinical JJ cord-334454-cqaado3u 106 28 improvement improvement NN cord-334454-cqaado3u 106 29 in in IN cord-334454-cqaado3u 106 30 treated treat VBN cord-334454-cqaado3u 106 31 cats cat NNS cord-334454-cqaado3u 106 32 . . . cord-334454-cqaado3u 107 1 Therefore therefore RB cord-334454-cqaado3u 107 2 , , , cord-334454-cqaado3u 107 3 even even RB cord-334454-cqaado3u 107 4 if if IN cord-334454-cqaado3u 107 5 the the DT cord-334454-cqaado3u 107 6 antiviral antiviral JJ cord-334454-cqaado3u 107 7 properties property NNS cord-334454-cqaado3u 107 8 against against IN cord-334454-cqaado3u 107 9 FIV FIV NNP cord-334454-cqaado3u 107 10 seem seem VBP cord-334454-cqaado3u 107 11 negligible negligible JJ cord-334454-cqaado3u 107 12 in in IN cord-334454-cqaado3u 107 13 both both DT cord-334454-cqaado3u 107 14 protocols protocol NNS cord-334454-cqaado3u 107 15 , , , cord-334454-cqaado3u 107 16 the the DT cord-334454-cqaado3u 107 17 fact fact NN cord-334454-cqaado3u 107 18 that that IN cord-334454-cqaado3u 107 19 there there EX cord-334454-cqaado3u 107 20 was be VBD cord-334454-cqaado3u 107 21 a a DT cord-334454-cqaado3u 107 22 decrease decrease NN cord-334454-cqaado3u 107 23 in in IN cord-334454-cqaado3u 107 24 concurrent concurrent JJ cord-334454-cqaado3u 107 25 viral viral JJ cord-334454-cqaado3u 107 26 infections infection NNS cord-334454-cqaado3u 107 27 in in IN cord-334454-cqaado3u 107 28 cats cat NNS cord-334454-cqaado3u 107 29 treated treat VBN cord-334454-cqaado3u 107 30 with with IN cord-334454-cqaado3u 107 31 the the DT cord-334454-cqaado3u 107 32 licensed licensed JJ cord-334454-cqaado3u 107 33 protocol protocol NN cord-334454-cqaado3u 107 34 raises raise VBZ cord-334454-cqaado3u 107 35 the the DT cord-334454-cqaado3u 107 36 question question NN cord-334454-cqaado3u 107 37 of of IN cord-334454-cqaado3u 107 38 whether whether IN cord-334454-cqaado3u 107 39 there there EX cord-334454-cqaado3u 107 40 is be VBZ cord-334454-cqaado3u 107 41 a a DT cord-334454-cqaado3u 107 42 true true JJ cord-334454-cqaado3u 107 43 antiviral antiviral JJ cord-334454-cqaado3u 107 44 effect effect NN cord-334454-cqaado3u 107 45 towards towards IN cord-334454-cqaado3u 107 46 other other JJ cord-334454-cqaado3u 107 47 viruses virus NNS cord-334454-cqaado3u 107 48 or or CC cord-334454-cqaado3u 107 49 whether whether IN cord-334454-cqaado3u 107 50 this this DT cord-334454-cqaado3u 107 51 is be VBZ cord-334454-cqaado3u 107 52 the the DT cord-334454-cqaado3u 107 53 result result NN cord-334454-cqaado3u 107 54 of of IN cord-334454-cqaado3u 107 55 an an DT cord-334454-cqaado3u 107 56 overall overall JJ cord-334454-cqaado3u 107 57 stimulation stimulation NN cord-334454-cqaado3u 107 58 of of IN cord-334454-cqaado3u 107 59 the the DT cord-334454-cqaado3u 107 60 innate innate JJ cord-334454-cqaado3u 107 61 and and CC cord-334454-cqaado3u 107 62 acquired acquire VBN cord-334454-cqaado3u 107 63 immune immune JJ cord-334454-cqaado3u 107 64 system system NN cord-334454-cqaado3u 107 65 . . . cord-334454-cqaado3u 108 1 From from IN cord-334454-cqaado3u 108 2 the the DT cord-334454-cqaado3u 108 3 authors author NNS cord-334454-cqaado3u 108 4 ' ' POS cord-334454-cqaado3u 108 5 point point NN cord-334454-cqaado3u 108 6 of of IN cord-334454-cqaado3u 108 7 view view NN cord-334454-cqaado3u 108 8 , , , cord-334454-cqaado3u 108 9 it -PRON- PRP cord-334454-cqaado3u 108 10 is be VBZ cord-334454-cqaado3u 108 11 overspeculative overspeculative VBN cord-334454-cqaado3u 108 12 to to IN cord-334454-cqaado3u 108 13 state state NN cord-334454-cqaado3u 108 14 that that IN cord-334454-cqaado3u 108 15 rFeIFN rfeifn NN cord-334454-cqaado3u 108 16 - - HYPH cord-334454-cqaado3u 108 17 ω ω NN cord-334454-cqaado3u 108 18 does do VBZ cord-334454-cqaado3u 108 19 not not RB cord-334454-cqaado3u 108 20 act act VB cord-334454-cqaado3u 108 21 on on IN cord-334454-cqaado3u 108 22 the the DT cord-334454-cqaado3u 108 23 acquired acquire VBN cord-334454-cqaado3u 108 24 immune immune JJ cord-334454-cqaado3u 108 25 system system NN cord-334454-cqaado3u 108 26 only only RB cord-334454-cqaado3u 108 27 based base VBN cord-334454-cqaado3u 108 28 on on IN cord-334454-cqaado3u 108 29 viremia viremia NN cord-334454-cqaado3u 108 30 and and CC cord-334454-cqaado3u 108 31 proviral proviral NNP cord-334454-cqaado3u 108 32 load load NNP cord-334454-cqaado3u 108 33 . . . cord-334454-cqaado3u 109 1 Therefore therefore RB cord-334454-cqaado3u 109 2 , , , cord-334454-cqaado3u 109 3 an an DT cord-334454-cqaado3u 109 4 evaluation evaluation NN cord-334454-cqaado3u 109 5 of of IN cord-334454-cqaado3u 109 6 cytokine cytokine NN cord-334454-cqaado3u 109 7 profiles profile NNS cord-334454-cqaado3u 109 8 in in IN cord-334454-cqaado3u 109 9 these these DT cord-334454-cqaado3u 109 10 animals animal NNS cord-334454-cqaado3u 109 11 seemed seem VBD cord-334454-cqaado3u 109 12 essential essential JJ cord-334454-cqaado3u 109 13 to to TO cord-334454-cqaado3u 109 14 fully fully RB cord-334454-cqaado3u 109 15 understand understand VB cord-334454-cqaado3u 109 16 the the DT cord-334454-cqaado3u 109 17 actions action NNS cord-334454-cqaado3u 109 18 of of IN cord-334454-cqaado3u 109 19 rFeIFN rFeIFN NNP cord-334454-cqaado3u 109 20 - - HYPH cord-334454-cqaado3u 109 21 ω ω NN cord-334454-cqaado3u 109 22 . . . cord-334454-cqaado3u 110 1 In in IN cord-334454-cqaado3u 110 2 order order NN cord-334454-cqaado3u 110 3 to to TO cord-334454-cqaado3u 110 4 reinforce reinforce VB cord-334454-cqaado3u 110 5 the the DT cord-334454-cqaado3u 110 6 previous previous JJ cord-334454-cqaado3u 110 7 suggestions suggestion NNS cord-334454-cqaado3u 110 8 that that IN cord-334454-cqaado3u 110 9 rFeIFN rfeifn NN cord-334454-cqaado3u 110 10 - - HYPH cord-334454-cqaado3u 110 11 ω ω NN cord-334454-cqaado3u 110 12 does do VBZ cord-334454-cqaado3u 110 13 not not RB cord-334454-cqaado3u 110 14 affect affect VB cord-334454-cqaado3u 110 15 the the DT cord-334454-cqaado3u 110 16 acquired acquire VBN cord-334454-cqaado3u 110 17 immune immune JJ cord-334454-cqaado3u 110 18 system system NN cord-334454-cqaado3u 110 19 of of IN cord-334454-cqaado3u 110 20 FIV fiv NN cord-334454-cqaado3u 110 21 - - HYPH cord-334454-cqaado3u 110 22 infected infect VBN cord-334454-cqaado3u 110 23 cats cat NNS cord-334454-cqaado3u 110 24 , , , cord-334454-cqaado3u 110 25 mRNA mrna NN cord-334454-cqaado3u 110 26 expression expression NN cord-334454-cqaado3u 110 27 and and CC cord-334454-cqaado3u 110 28 concurrent concurrent JJ cord-334454-cqaado3u 110 29 plasma plasma NN cord-334454-cqaado3u 110 30 levels level NNS cord-334454-cqaado3u 110 31 of of IN cord-334454-cqaado3u 110 32 various various JJ cord-334454-cqaado3u 110 33 cytokines cytokine NNS cord-334454-cqaado3u 110 34 were be VBD cord-334454-cqaado3u 110 35 monitored monitor VBN cord-334454-cqaado3u 110 36 using use VBG cord-334454-cqaado3u 110 37 biological biological JJ cord-334454-cqaado3u 110 38 samples sample NNS cord-334454-cqaado3u 110 39 from from IN cord-334454-cqaado3u 110 40 the the DT cord-334454-cqaado3u 110 41 two two CD cord-334454-cqaado3u 110 42 groups group NNS cord-334454-cqaado3u 110 43 of of IN cord-334454-cqaado3u 110 44 FIV fiv NN cord-334454-cqaado3u 110 45 - - HYPH cord-334454-cqaado3u 110 46 infected infect VBN cord-334454-cqaado3u 110 47 cats cat NNS cord-334454-cqaado3u 110 48 treated treat VBN cord-334454-cqaado3u 110 49 with with IN cord-334454-cqaado3u 110 50 either either CC cord-334454-cqaado3u 110 51 subcutaneous subcutaneous JJ cord-334454-cqaado3u 110 52 or or CC cord-334454-cqaado3u 110 53 oral oral JJ cord-334454-cqaado3u 110 54 rFEIFN rfeifn NN cord-334454-cqaado3u 110 55 - - HYPH cord-334454-cqaado3u 110 56 ω ω JJS cord-334454-cqaado3u 110 57 protocols protocol NNS cord-334454-cqaado3u 110 58 [ [ -LRB- cord-334454-cqaado3u 110 59 27 27 CD cord-334454-cqaado3u 110 60 ] ] -RRB- cord-334454-cqaado3u 110 61 . . . cord-334454-cqaado3u 111 1 Despite despite IN cord-334454-cqaado3u 111 2 its -PRON- PRP$ cord-334454-cqaado3u 111 3 pleiotropic pleiotropic JJ cord-334454-cqaado3u 111 4 effect effect NN cord-334454-cqaado3u 111 5 , , , cord-334454-cqaado3u 111 6 variations variation NNS cord-334454-cqaado3u 111 7 of of IN cord-334454-cqaado3u 111 8 Th-1 Th-1 NNP cord-334454-cqaado3u 111 9 and and CC cord-334454-cqaado3u 111 10 Th-2 Th-2 NNP cord-334454-cqaado3u 111 11 responses response NNS cord-334454-cqaado3u 111 12 were be VBD cord-334454-cqaado3u 111 13 assessed assess VBN cord-334454-cqaado3u 111 14 based base VBN cord-334454-cqaado3u 111 15 on on IN cord-334454-cqaado3u 111 16 different different JJ cord-334454-cqaado3u 111 17 measured measure VBN cord-334454-cqaado3u 111 18 cytokines cytokine NNS cord-334454-cqaado3u 111 19 . . . cord-334454-cqaado3u 112 1 Results result NNS cord-334454-cqaado3u 112 2 showed show VBD cord-334454-cqaado3u 112 3 that that IN cord-334454-cqaado3u 112 4 Th-1 Th-1 NNP cord-334454-cqaado3u 112 5 and and CC cord-334454-cqaado3u 112 6 Th-2 Th-2 NNP cord-334454-cqaado3u 112 7 responses response NNS cord-334454-cqaado3u 112 8 did do VBD cord-334454-cqaado3u 112 9 not not RB cord-334454-cqaado3u 112 10 significantly significantly RB cord-334454-cqaado3u 112 11 change change VB cord-334454-cqaado3u 112 12 in in IN cord-334454-cqaado3u 112 13 either either DT cord-334454-cqaado3u 112 14 protocol protocol NN cord-334454-cqaado3u 112 15 , , , cord-334454-cqaado3u 112 16 which which WDT cord-334454-cqaado3u 112 17 supported support VBD cord-334454-cqaado3u 112 18 the the DT cord-334454-cqaado3u 112 19 previous previous JJ cord-334454-cqaado3u 112 20 suggestions suggestion NNS cord-334454-cqaado3u 112 21 that that IN cord-334454-cqaado3u 112 22 rFeIFN rfeifn NN cord-334454-cqaado3u 112 23 - - HYPH cord-334454-cqaado3u 112 24 ω ω NN cord-334454-cqaado3u 112 25 does do VBZ cord-334454-cqaado3u 112 26 not not RB cord-334454-cqaado3u 112 27 strongly strongly RB cord-334454-cqaado3u 112 28 affect affect VB cord-334454-cqaado3u 112 29 the the DT cord-334454-cqaado3u 112 30 acquired acquire VBN cord-334454-cqaado3u 112 31 immune immune JJ cord-334454-cqaado3u 112 32 system system NN cord-334454-cqaado3u 112 33 . . . cord-334454-cqaado3u 113 1 Among among IN cord-334454-cqaado3u 113 2 the the DT cord-334454-cqaado3u 113 3 measured measure VBN cord-334454-cqaado3u 113 4 cytokines cytokine NNS cord-334454-cqaado3u 113 5 , , , cord-334454-cqaado3u 113 6 only only RB cord-334454-cqaado3u 113 7 IL-6 IL-6 NNP cord-334454-cqaado3u 113 8 ( ( -LRB- cord-334454-cqaado3u 113 9 a a DT cord-334454-cqaado3u 113 10 pro pro JJ cord-334454-cqaado3u 113 11 - - JJ cord-334454-cqaado3u 113 12 inflammatory inflammatory JJ cord-334454-cqaado3u 113 13 cytokine cytokine NN cord-334454-cqaado3u 113 14 involved involve VBN cord-334454-cqaado3u 113 15 in in IN cord-334454-cqaado3u 113 16 different different JJ cord-334454-cqaado3u 113 17 immune immune JJ cord-334454-cqaado3u 113 18 pathways pathway NNS cord-334454-cqaado3u 113 19 and and CC cord-334454-cqaado3u 113 20 particularly particularly RB cord-334454-cqaado3u 113 21 in in IN cord-334454-cqaado3u 113 22 the the DT cord-334454-cqaado3u 113 23 innate innate JJ cord-334454-cqaado3u 113 24 immune immune JJ cord-334454-cqaado3u 113 25 response response NN cord-334454-cqaado3u 113 26 ) ) -RRB- cord-334454-cqaado3u 113 27 significantly significantly RB cord-334454-cqaado3u 113 28 changed change VBD cord-334454-cqaado3u 113 29 in in IN cord-334454-cqaado3u 113 30 both both DT cord-334454-cqaado3u 113 31 groups group NNS cord-334454-cqaado3u 113 32 . . . cord-334454-cqaado3u 114 1 In in IN cord-334454-cqaado3u 114 2 fact fact NN cord-334454-cqaado3u 114 3 , , , cord-334454-cqaado3u 114 4 in in IN cord-334454-cqaado3u 114 5 cats cat NNS cord-334454-cqaado3u 114 6 treated treat VBN cord-334454-cqaado3u 114 7 with with IN cord-334454-cqaado3u 114 8 the the DT cord-334454-cqaado3u 114 9 licensed licensed JJ cord-334454-cqaado3u 114 10 protocol protocol NN cord-334454-cqaado3u 114 11 , , , cord-334454-cqaado3u 114 12 IL-6 IL-6 NNP cord-334454-cqaado3u 114 13 plasma plasma NN cord-334454-cqaado3u 114 14 levels level NNS cord-334454-cqaado3u 114 15 were be VBD cord-334454-cqaado3u 114 16 significantly significantly RB cord-334454-cqaado3u 114 17 reduced reduce VBN cord-334454-cqaado3u 114 18 , , , cord-334454-cqaado3u 114 19 whilst whilst IN cord-334454-cqaado3u 114 20 its -PRON- PRP$ cord-334454-cqaado3u 114 21 respective respective JJ cord-334454-cqaado3u 114 22 mRNA mRNA NNP cord-334454-cqaado3u 114 23 expression expression NN cord-334454-cqaado3u 114 24 showed show VBD cord-334454-cqaado3u 114 25 a a DT cord-334454-cqaado3u 114 26 decreasing decrease VBG cord-334454-cqaado3u 114 27 tendency tendency NN cord-334454-cqaado3u 114 28 that that WDT cord-334454-cqaado3u 114 29 was be VBD cord-334454-cqaado3u 114 30 not not RB cord-334454-cqaado3u 114 31 statistically statistically RB cord-334454-cqaado3u 114 32 significant significant JJ cord-334454-cqaado3u 114 33 . . . cord-334454-cqaado3u 115 1 On on IN cord-334454-cqaado3u 115 2 the the DT cord-334454-cqaado3u 115 3 other other JJ cord-334454-cqaado3u 115 4 hand hand NN cord-334454-cqaado3u 115 5 , , , cord-334454-cqaado3u 115 6 in in IN cord-334454-cqaado3u 115 7 cats cat NNS cord-334454-cqaado3u 115 8 treated treat VBN cord-334454-cqaado3u 115 9 with with IN cord-334454-cqaado3u 115 10 oral oral JJ cord-334454-cqaado3u 115 11 rFEIFN rfeifn NN cord-334454-cqaado3u 115 12 - - HYPH cord-334454-cqaado3u 115 13 ω ω JJ cord-334454-cqaado3u 115 14 , , , cord-334454-cqaado3u 115 15 IL-6 IL-6 NNP cord-334454-cqaado3u 115 16 plasma plasma NN cord-334454-cqaado3u 115 17 levels level NNS cord-334454-cqaado3u 115 18 did do VBD cord-334454-cqaado3u 115 19 not not RB cord-334454-cqaado3u 115 20 change change VB cord-334454-cqaado3u 115 21 , , , cord-334454-cqaado3u 115 22 but but CC cord-334454-cqaado3u 115 23 the the DT cord-334454-cqaado3u 115 24 concurrent concurrent JJ cord-334454-cqaado3u 115 25 mRNA mRNA NNP cord-334454-cqaado3u 115 26 expression expression NN cord-334454-cqaado3u 115 27 significantly significantly RB cord-334454-cqaado3u 115 28 decreased decrease VBD cord-334454-cqaado3u 115 29 . . . cord-334454-cqaado3u 116 1 All all DT cord-334454-cqaado3u 116 2 in in RB cord-334454-cqaado3u 116 3 all all DT cord-334454-cqaado3u 116 4 , , , cord-334454-cqaado3u 116 5 it -PRON- PRP cord-334454-cqaado3u 116 6 was be VBD cord-334454-cqaado3u 116 7 documented document VBN cord-334454-cqaado3u 116 8 that that IN cord-334454-cqaado3u 116 9 IL-6 IL-6 NNP cord-334454-cqaado3u 116 10 production production NN cord-334454-cqaado3u 116 11 is be VBZ cord-334454-cqaado3u 116 12 affected affect VBN cord-334454-cqaado3u 116 13 in in IN cord-334454-cqaado3u 116 14 both both DT cord-334454-cqaado3u 116 15 protocols protocol NNS cord-334454-cqaado3u 116 16 , , , cord-334454-cqaado3u 116 17 meaning mean VBG cord-334454-cqaado3u 116 18 that that IN cord-334454-cqaado3u 116 19 rFeIFN rfeifn NN cord-334454-cqaado3u 116 20 - - HYPH cord-334454-cqaado3u 116 21 ω ω NN cord-334454-cqaado3u 116 22 has have VBZ cord-334454-cqaado3u 116 23 anti anti JJ cord-334454-cqaado3u 116 24 - - JJ cord-334454-cqaado3u 116 25 inflammatory inflammatory JJ cord-334454-cqaado3u 116 26 properties property NNS cord-334454-cqaado3u 116 27 . . . cord-334454-cqaado3u 117 1 Moreover moreover RB cord-334454-cqaado3u 117 2 , , , cord-334454-cqaado3u 117 3 considering consider VBG cord-334454-cqaado3u 117 4 that that IN cord-334454-cqaado3u 117 5 plasma plasma NN cord-334454-cqaado3u 117 6 changes change NNS cord-334454-cqaado3u 117 7 were be VBD cord-334454-cqaado3u 117 8 only only RB cord-334454-cqaado3u 117 9 significant significant JJ cord-334454-cqaado3u 117 10 in in IN cord-334454-cqaado3u 117 11 cats cat NNS cord-334454-cqaado3u 117 12 treated treat VBN cord-334454-cqaado3u 117 13 with with IN cord-334454-cqaado3u 117 14 the the DT cord-334454-cqaado3u 117 15 licensed licensed JJ cord-334454-cqaado3u 117 16 protocol protocol NN cord-334454-cqaado3u 117 17 , , , cord-334454-cqaado3u 117 18 it -PRON- PRP cord-334454-cqaado3u 117 19 seems seem VBZ cord-334454-cqaado3u 117 20 reasonable reasonable JJ cord-334454-cqaado3u 117 21 to to IN cord-334454-cqaado3u 117 22 state state VB cord-334454-cqaado3u 117 23 that that IN cord-334454-cqaado3u 117 24 this this DT cord-334454-cqaado3u 117 25 higher high JJR cord-334454-cqaado3u 117 26 pulsate pulsate VBP cord-334454-cqaado3u 117 27 therapeutic therapeutic JJ cord-334454-cqaado3u 117 28 scheme scheme NN cord-334454-cqaado3u 117 29 is be VBZ cord-334454-cqaado3u 117 30 more more RBR cord-334454-cqaado3u 117 31 efficient efficient JJ cord-334454-cqaado3u 117 32 in in IN cord-334454-cqaado3u 117 33 reducing reduce VBG cord-334454-cqaado3u 117 34 the the DT cord-334454-cqaado3u 117 35 pro pro JJ cord-334454-cqaado3u 117 36 - - JJ cord-334454-cqaado3u 117 37 inflammatory inflammatory JJ cord-334454-cqaado3u 117 38 stimuli stimulus NNS cord-334454-cqaado3u 117 39 than than IN cord-334454-cqaado3u 117 40 the the DT cord-334454-cqaado3u 117 41 continuous continuous JJ cord-334454-cqaado3u 117 42 low low JJ cord-334454-cqaado3u 117 43 dose dose NN cord-334454-cqaado3u 117 44 therapy therapy NN cord-334454-cqaado3u 117 45 . . . cord-334454-cqaado3u 118 1 These these DT cord-334454-cqaado3u 118 2 were be VBD cord-334454-cqaado3u 118 3 the the DT cord-334454-cqaado3u 118 4 first first JJ cord-334454-cqaado3u 118 5 studies study NNS cord-334454-cqaado3u 118 6 exploring explore VBG cord-334454-cqaado3u 118 7 the the DT cord-334454-cqaado3u 118 8 effect effect NN cord-334454-cqaado3u 118 9 of of IN cord-334454-cqaado3u 118 10 rFeIFN rfeifn NN cord-334454-cqaado3u 118 11 - - HYPH cord-334454-cqaado3u 118 12 ω ω JJ cord-334454-cqaado3u 118 13 in in IN cord-334454-cqaado3u 118 14 different different JJ cord-334454-cqaado3u 118 15 biomarkers biomarker NNS cord-334454-cqaado3u 118 16 of of IN cord-334454-cqaado3u 118 17 the the DT cord-334454-cqaado3u 118 18 immune immune JJ cord-334454-cqaado3u 118 19 system system NN cord-334454-cqaado3u 118 20 . . . cord-334454-cqaado3u 119 1 However however RB cord-334454-cqaado3u 119 2 , , , cord-334454-cqaado3u 119 3 there there EX cord-334454-cqaado3u 119 4 are be VBP cord-334454-cqaado3u 119 5 still still RB cord-334454-cqaado3u 119 6 many many JJ cord-334454-cqaado3u 119 7 points point NNS cord-334454-cqaado3u 119 8 to to TO cord-334454-cqaado3u 119 9 investigate investigate VB cord-334454-cqaado3u 119 10 in in IN cord-334454-cqaado3u 119 11 order order NN cord-334454-cqaado3u 119 12 to to TO cord-334454-cqaado3u 119 13 explore explore VB cord-334454-cqaado3u 119 14 the the DT cord-334454-cqaado3u 119 15 whole whole JJ cord-334454-cqaado3u 119 16 potential potential NN cord-334454-cqaado3u 119 17 of of IN cord-334454-cqaado3u 119 18 this this DT cord-334454-cqaado3u 119 19 compound compound NN cord-334454-cqaado3u 119 20 in in IN cord-334454-cqaado3u 119 21 retroviral retroviral JJ cord-334454-cqaado3u 119 22 infections infection NNS cord-334454-cqaado3u 119 23 . . . cord-334454-cqaado3u 120 1 In in IN cord-334454-cqaado3u 120 2 FIV FIV NNP cord-334454-cqaado3u 120 3 - - HYPH cord-334454-cqaado3u 120 4 infected infect VBN cord-334454-cqaado3u 120 5 cats cat NNS cord-334454-cqaado3u 120 6 , , , cord-334454-cqaado3u 120 7 only only RB cord-334454-cqaado3u 120 8 two two CD cord-334454-cqaado3u 120 9 protocols protocol NNS cord-334454-cqaado3u 120 10 were be VBD cord-334454-cqaado3u 120 11 assessed assess VBN cord-334454-cqaado3u 120 12 . . . cord-334454-cqaado3u 121 1 Following follow VBG cord-334454-cqaado3u 121 2 the the DT cord-334454-cqaado3u 121 3 same same JJ cord-334454-cqaado3u 121 4 research research NN cord-334454-cqaado3u 121 5 line line NN cord-334454-cqaado3u 121 6 , , , cord-334454-cqaado3u 121 7 it -PRON- PRP cord-334454-cqaado3u 121 8 would would MD cord-334454-cqaado3u 121 9 be be VB cord-334454-cqaado3u 121 10 interesting interesting JJ cord-334454-cqaado3u 121 11 to to TO cord-334454-cqaado3u 121 12 reinforce reinforce VB cord-334454-cqaado3u 121 13 these these DT cord-334454-cqaado3u 121 14 conclusions conclusion NNS cord-334454-cqaado3u 121 15 with with IN cord-334454-cqaado3u 121 16 pharmacokinetic pharmacokinetic JJ cord-334454-cqaado3u 121 17 and and CC cord-334454-cqaado3u 121 18 pharmacodynamic pharmacodynamic JJ cord-334454-cqaado3u 121 19 studies study NNS cord-334454-cqaado3u 121 20 . . . cord-334454-cqaado3u 122 1 In in IN cord-334454-cqaado3u 122 2 the the DT cord-334454-cqaado3u 122 3 subcutaneous subcutaneous JJ cord-334454-cqaado3u 122 4 protocol protocol NN cord-334454-cqaado3u 122 5 , , , cord-334454-cqaado3u 122 6 it -PRON- PRP cord-334454-cqaado3u 122 7 would would MD cord-334454-cqaado3u 122 8 be be VB cord-334454-cqaado3u 122 9 useful useful JJ cord-334454-cqaado3u 122 10 to to TO cord-334454-cqaado3u 122 11 document document VB cord-334454-cqaado3u 122 12 the the DT cord-334454-cqaado3u 122 13 effect effect NN cord-334454-cqaado3u 122 14 of of IN cord-334454-cqaado3u 122 15 lower low JJR cord-334454-cqaado3u 122 16 doses dose NNS cord-334454-cqaado3u 122 17 but but CC cord-334454-cqaado3u 123 1 in in IN cord-334454-cqaado3u 123 2 longer long JJR cord-334454-cqaado3u 123 3 therapy therapy NN cord-334454-cqaado3u 123 4 cycles cycle NNS cord-334454-cqaado3u 123 5 and and CC cord-334454-cqaado3u 123 6 vice vice NN cord-334454-cqaado3u 123 7 - - HYPH cord-334454-cqaado3u 123 8 versa versa RB cord-334454-cqaado3u 123 9 , , , cord-334454-cqaado3u 123 10 in in IN cord-334454-cqaado3u 123 11 order order NN cord-334454-cqaado3u 123 12 to to TO cord-334454-cqaado3u 123 13 correlate correlate VB cord-334454-cqaado3u 123 14 the the DT cord-334454-cqaado3u 123 15 therapy therapy NN cord-334454-cqaado3u 123 16 requirements requirement NNS cord-334454-cqaado3u 123 17 with with IN cord-334454-cqaado3u 123 18 clinical clinical JJ cord-334454-cqaado3u 123 19 and and CC cord-334454-cqaado3u 123 20 virological virological JJ cord-334454-cqaado3u 123 21 conditions condition NNS cord-334454-cqaado3u 123 22 . . . cord-334454-cqaado3u 124 1 For for IN cord-334454-cqaado3u 124 2 the the DT cord-334454-cqaado3u 124 3 oral oral JJ cord-334454-cqaado3u 124 4 group group NN cord-334454-cqaado3u 124 5 , , , cord-334454-cqaado3u 124 6 it -PRON- PRP cord-334454-cqaado3u 124 7 would would MD cord-334454-cqaado3u 124 8 also also RB cord-334454-cqaado3u 124 9 be be VB cord-334454-cqaado3u 124 10 interesting interesting JJ cord-334454-cqaado3u 124 11 to to TO cord-334454-cqaado3u 124 12 assess assess VB cord-334454-cqaado3u 124 13 the the DT cord-334454-cqaado3u 124 14 effect effect NN cord-334454-cqaado3u 124 15 of of IN cord-334454-cqaado3u 124 16 intermediate intermediate JJ cord-334454-cqaado3u 124 17 higher high JJR cord-334454-cqaado3u 124 18 doses dose NNS cord-334454-cqaado3u 124 19 for for IN cord-334454-cqaado3u 124 20 shorter short JJR cord-334454-cqaado3u 124 21 periods period NNS cord-334454-cqaado3u 124 22 and and CC cord-334454-cqaado3u 124 23 also also RB cord-334454-cqaado3u 124 24 to to TO cord-334454-cqaado3u 124 25 extend extend VB cord-334454-cqaado3u 124 26 the the DT cord-334454-cqaado3u 124 27 protocol protocol NN cord-334454-cqaado3u 124 28 to to IN cord-334454-cqaado3u 124 29 FeLV FeLV NNP cord-334454-cqaado3u 124 30 - - HYPH cord-334454-cqaado3u 124 31 infected infect VBN cord-334454-cqaado3u 124 32 cats cat NNS cord-334454-cqaado3u 124 33 . . . cord-334454-cqaado3u 125 1 In in IN cord-334454-cqaado3u 125 2 spite spite NN cord-334454-cqaado3u 125 3 of of IN cord-334454-cqaado3u 125 4 the the DT cord-334454-cqaado3u 125 5 different different JJ cord-334454-cqaado3u 125 6 physiopathology physiopathology NN cord-334454-cqaado3u 125 7 and and CC cord-334454-cqaado3u 125 8 the the DT cord-334454-cqaado3u 125 9 aggressive aggressive JJ cord-334454-cqaado3u 125 10 clinical clinical JJ cord-334454-cqaado3u 125 11 portrait portrait NN cord-334454-cqaado3u 125 12 , , , cord-334454-cqaado3u 125 13 it -PRON- PRP cord-334454-cqaado3u 125 14 would would MD cord-334454-cqaado3u 125 15 be be VB cord-334454-cqaado3u 125 16 interesting interesting JJ cord-334454-cqaado3u 125 17 to to TO cord-334454-cqaado3u 125 18 assess assess VB cord-334454-cqaado3u 125 19 the the DT cord-334454-cqaado3u 125 20 effect effect NN cord-334454-cqaado3u 125 21 of of IN cord-334454-cqaado3u 125 22 the the DT cord-334454-cqaado3u 125 23 suggested suggest VBN cord-334454-cqaado3u 125 24 oral oral JJ cord-334454-cqaado3u 125 25 rFeIFN rfeifn NN cord-334454-cqaado3u 125 26 - - HYPH cord-334454-cqaado3u 125 27 ω ω JJ cord-334454-cqaado3u 125 28 in in IN cord-334454-cqaado3u 125 29 these these DT cord-334454-cqaado3u 125 30 animals animal NNS cord-334454-cqaado3u 125 31 . . . cord-334454-cqaado3u 126 1 According accord VBG cord-334454-cqaado3u 126 2 to to IN cord-334454-cqaado3u 126 3 the the DT cord-334454-cqaado3u 126 4 authors author NNS cord-334454-cqaado3u 126 5 ' ' POS cord-334454-cqaado3u 126 6 point point NN cord-334454-cqaado3u 126 7 of of IN cord-334454-cqaado3u 126 8 view view NN cord-334454-cqaado3u 126 9 , , , cord-334454-cqaado3u 126 10 it -PRON- PRP cord-334454-cqaado3u 126 11 is be VBZ cord-334454-cqaado3u 126 12 unlikely unlikely JJ cord-334454-cqaado3u 126 13 that that IN cord-334454-cqaado3u 126 14 such such PDT cord-334454-cqaado3u 126 15 a a DT cord-334454-cqaado3u 126 16 lower low JJR cord-334454-cqaado3u 126 17 oral oral JJ cord-334454-cqaado3u 126 18 dose dose NN cord-334454-cqaado3u 126 19 will will MD cord-334454-cqaado3u 126 20 have have VB cord-334454-cqaado3u 126 21 the the DT cord-334454-cqaado3u 126 22 same same JJ cord-334454-cqaado3u 126 23 effect effect NN cord-334454-cqaado3u 126 24 on on IN cord-334454-cqaado3u 126 25 clinical clinical JJ cord-334454-cqaado3u 126 26 improvement improvement NN cord-334454-cqaado3u 126 27 of of IN cord-334454-cqaado3u 126 28 FeLV FeLV NNP cord-334454-cqaado3u 126 29 - - HYPH cord-334454-cqaado3u 126 30 infected infect VBN cord-334454-cqaado3u 126 31 cats cat NNS cord-334454-cqaado3u 126 32 since since IN cord-334454-cqaado3u 126 33 these these DT cord-334454-cqaado3u 126 34 animals animal NNS cord-334454-cqaado3u 126 35 are be VBP cord-334454-cqaado3u 126 36 usually usually RB cord-334454-cqaado3u 126 37 more more RBR cord-334454-cqaado3u 126 38 symptomatic symptomatic JJ cord-334454-cqaado3u 126 39 and and CC cord-334454-cqaado3u 126 40 in in IN cord-334454-cqaado3u 126 41 worse bad JJR cord-334454-cqaado3u 126 42 overall overall JJ cord-334454-cqaado3u 126 43 clinical clinical JJ cord-334454-cqaado3u 126 44 condition condition NN cord-334454-cqaado3u 126 45 than than IN cord-334454-cqaado3u 126 46 FIV fiv NN cord-334454-cqaado3u 126 47 - - HYPH cord-334454-cqaado3u 126 48 infected infect VBN cord-334454-cqaado3u 126 49 animals animal NNS cord-334454-cqaado3u 126 50 . . . cord-334454-cqaado3u 127 1 Consequently consequently RB cord-334454-cqaado3u 127 2 , , , cord-334454-cqaado3u 127 3 the the DT cord-334454-cqaado3u 127 4 higher high JJR cord-334454-cqaado3u 127 5 subcutaneous subcutaneous JJ cord-334454-cqaado3u 127 6 protocol protocol NN cord-334454-cqaado3u 127 7 will will MD cord-334454-cqaado3u 127 8 always always RB cord-334454-cqaado3u 127 9 be be VB cord-334454-cqaado3u 127 10 preferable preferable JJ cord-334454-cqaado3u 127 11 in in IN cord-334454-cqaado3u 127 12 these these DT cord-334454-cqaado3u 127 13 cats cat NNS cord-334454-cqaado3u 127 14 . . . cord-334454-cqaado3u 128 1 As as IN cord-334454-cqaado3u 128 2 previously previously RB cord-334454-cqaado3u 128 3 stated state VBN cord-334454-cqaado3u 128 4 , , , cord-334454-cqaado3u 128 5 several several JJ cord-334454-cqaado3u 128 6 studies study NNS cord-334454-cqaado3u 128 7 have have VBP cord-334454-cqaado3u 128 8 shown show VBN cord-334454-cqaado3u 128 9 that that IN cord-334454-cqaado3u 128 10 IFNs ifn NNS cord-334454-cqaado3u 128 11 can can MD cord-334454-cqaado3u 128 12 be be VB cord-334454-cqaado3u 128 13 beneficial beneficial JJ cord-334454-cqaado3u 128 14 in in IN cord-334454-cqaado3u 128 15 the the DT cord-334454-cqaado3u 128 16 early early JJ cord-334454-cqaado3u 128 17 stages stage NNS cord-334454-cqaado3u 128 18 of of IN cord-334454-cqaado3u 128 19 HIV HIV NNP cord-334454-cqaado3u 128 20 infection infection NN cord-334454-cqaado3u 128 21 [ [ -LRB- cord-334454-cqaado3u 128 22 15 15 CD cord-334454-cqaado3u 128 23 ] ] -RRB- cord-334454-cqaado3u 128 24 . . . cord-334454-cqaado3u 129 1 Recognizing recognize VBG cord-334454-cqaado3u 129 2 that that IN cord-334454-cqaado3u 129 3 these these DT cord-334454-cqaado3u 129 4 results result NNS cord-334454-cqaado3u 129 5 concern concern NN cord-334454-cqaado3u 129 6 naturally naturally RB cord-334454-cqaado3u 129 7 infected infect VBN cord-334454-cqaado3u 129 8 cats cat NNS cord-334454-cqaado3u 129 9 in in IN cord-334454-cqaado3u 129 10 which which WDT cord-334454-cqaado3u 129 11 the the DT cord-334454-cqaado3u 129 12 time time NN cord-334454-cqaado3u 129 13 of of IN cord-334454-cqaado3u 129 14 infection infection NN cord-334454-cqaado3u 129 15 is be VBZ cord-334454-cqaado3u 129 16 unknown unknown JJ cord-334454-cqaado3u 129 17 , , , cord-334454-cqaado3u 129 18 these these DT cord-334454-cqaado3u 129 19 findings finding NNS cord-334454-cqaado3u 129 20 are be VBP cord-334454-cqaado3u 129 21 in in IN cord-334454-cqaado3u 129 22 some some DT cord-334454-cqaado3u 129 23 way way NN cord-334454-cqaado3u 129 24 in in IN cord-334454-cqaado3u 129 25 agreement agreement NN cord-334454-cqaado3u 129 26 with with IN cord-334454-cqaado3u 129 27 these these DT cord-334454-cqaado3u 129 28 HIV HIV NNP cord-334454-cqaado3u 129 29 studies study NNS cord-334454-cqaado3u 129 30 as as IN cord-334454-cqaado3u 129 31 they -PRON- PRP cord-334454-cqaado3u 129 32 indirectly indirectly RB cord-334454-cqaado3u 129 33 reflect reflect VBP cord-334454-cqaado3u 129 34 an an DT cord-334454-cqaado3u 129 35 innate innate JJ cord-334454-cqaado3u 129 36 immune immune JJ cord-334454-cqaado3u 129 37 - - HYPH cord-334454-cqaado3u 129 38 modulation modulation NN cord-334454-cqaado3u 129 39 and and CC cord-334454-cqaado3u 129 40 decrease decrease NN cord-334454-cqaado3u 129 41 in in IN cord-334454-cqaado3u 129 42 clinical clinical JJ cord-334454-cqaado3u 129 43 signs sign NNS cord-334454-cqaado3u 129 44 and and CC cord-334454-cqaado3u 129 45 co co NNS cord-334454-cqaado3u 129 46 - - NNS cord-334454-cqaado3u 129 47 infections infection NNS cord-334454-cqaado3u 129 48 . . . cord-334454-cqaado3u 130 1 Compared compare VBN cord-334454-cqaado3u 130 2 with with IN cord-334454-cqaado3u 130 3 exploring explore VBG cord-334454-cqaado3u 130 4 the the DT cord-334454-cqaado3u 130 5 full full JJ cord-334454-cqaado3u 130 6 potential potential NN cord-334454-cqaado3u 130 7 of of IN cord-334454-cqaado3u 130 8 each each DT cord-334454-cqaado3u 130 9 route route NN cord-334454-cqaado3u 130 10 and and CC cord-334454-cqaado3u 130 11 dose dose NN cord-334454-cqaado3u 130 12 , , , cord-334454-cqaado3u 130 13 it -PRON- PRP cord-334454-cqaado3u 130 14 would would MD cord-334454-cqaado3u 130 15 be be VB cord-334454-cqaado3u 130 16 interesting interesting JJ cord-334454-cqaado3u 130 17 to to TO cord-334454-cqaado3u 130 18 study study VB cord-334454-cqaado3u 130 19 a a DT cord-334454-cqaado3u 130 20 combination combination NN cord-334454-cqaado3u 130 21 of of IN cord-334454-cqaado3u 130 22 protocols protocol NNS cord-334454-cqaado3u 130 23 to to TO cord-334454-cqaado3u 130 24 be be VB cord-334454-cqaado3u 130 25 used use VBN cord-334454-cqaado3u 130 26 according accord VBG cord-334454-cqaado3u 130 27 to to IN cord-334454-cqaado3u 130 28 different different JJ cord-334454-cqaado3u 130 29 clinical clinical JJ cord-334454-cqaado3u 130 30 presentations presentation NNS cord-334454-cqaado3u 130 31 . . . cord-334454-cqaado3u 131 1 Although although IN cord-334454-cqaado3u 131 2 there there EX cord-334454-cqaado3u 131 3 are be VBP cord-334454-cqaado3u 131 4 no no DT cord-334454-cqaado3u 131 5 studies study NNS cord-334454-cqaado3u 131 6 assessing assess VBG cord-334454-cqaado3u 131 7 a a DT cord-334454-cqaado3u 131 8 possible possible JJ cord-334454-cqaado3u 131 9 combination combination NN cord-334454-cqaado3u 131 10 of of IN cord-334454-cqaado3u 131 11 both both DT cord-334454-cqaado3u 131 12 protocols protocol NNS cord-334454-cqaado3u 131 13 , , , cord-334454-cqaado3u 131 14 we -PRON- PRP cord-334454-cqaado3u 131 15 think think VBP cord-334454-cqaado3u 131 16 that that IN cord-334454-cqaado3u 131 17 they -PRON- PRP cord-334454-cqaado3u 131 18 can can MD cord-334454-cqaado3u 131 19 be be VB cord-334454-cqaado3u 131 20 reasonably reasonably RB cord-334454-cqaado3u 131 21 associated associate VBN cord-334454-cqaado3u 131 22 , , , cord-334454-cqaado3u 131 23 as as IN cord-334454-cqaado3u 131 24 both both DT cord-334454-cqaado3u 131 25 therapies therapy NNS cord-334454-cqaado3u 131 26 are be VBP cord-334454-cqaado3u 131 27 well well RB cord-334454-cqaado3u 131 28 documented documented JJ cord-334454-cqaado3u 131 29 and and CC cord-334454-cqaado3u 131 30 do do VBP cord-334454-cqaado3u 131 31 not not RB cord-334454-cqaado3u 131 32 show show VB cord-334454-cqaado3u 131 33 important important JJ cord-334454-cqaado3u 131 34 adverse adverse JJ cord-334454-cqaado3u 131 35 effects effect NNS cord-334454-cqaado3u 131 36 . . . cord-334454-cqaado3u 132 1 For for IN cord-334454-cqaado3u 132 2 instance instance NN cord-334454-cqaado3u 132 3 , , , cord-334454-cqaado3u 132 4 in in IN cord-334454-cqaado3u 132 5 symptomatic symptomatic JJ cord-334454-cqaado3u 132 6 animals animal NNS cord-334454-cqaado3u 132 7 , , , cord-334454-cqaado3u 132 8 an an DT cord-334454-cqaado3u 132 9 initial initial JJ cord-334454-cqaado3u 132 10 subcutaneous subcutaneous JJ cord-334454-cqaado3u 132 11 protocol protocol NN cord-334454-cqaado3u 132 12 followed follow VBN cord-334454-cqaado3u 132 13 by by IN cord-334454-cqaado3u 132 14 an an DT cord-334454-cqaado3u 132 15 oral oral JJ cord-334454-cqaado3u 132 16 continuous continuous JJ cord-334454-cqaado3u 132 17 lower low JJR cord-334454-cqaado3u 132 18 - - HYPH cord-334454-cqaado3u 132 19 dose dose NN cord-334454-cqaado3u 132 20 therapy therapy NN cord-334454-cqaado3u 132 21 can can MD cord-334454-cqaado3u 132 22 now now RB cord-334454-cqaado3u 132 23 be be VB cord-334454-cqaado3u 132 24 recommended recommend VBN cord-334454-cqaado3u 132 25 . . . cord-334454-cqaado3u 133 1 From from IN cord-334454-cqaado3u 133 2 the the DT cord-334454-cqaado3u 133 3 authors author NNS cord-334454-cqaado3u 133 4 ' ' POS cord-334454-cqaado3u 133 5 point point NN cord-334454-cqaado3u 133 6 of of IN cord-334454-cqaado3u 133 7 view view NN cord-334454-cqaado3u 133 8 , , , cord-334454-cqaado3u 133 9 this this DT cord-334454-cqaado3u 133 10 seems seem VBZ cord-334454-cqaado3u 133 11 a a DT cord-334454-cqaado3u 133 12 reasonable reasonable JJ cord-334454-cqaado3u 133 13 approach approach NN cord-334454-cqaado3u 133 14 that that IN cord-334454-cqaado3u 133 15 sooner soon RBR cord-334454-cqaado3u 133 16 or or CC cord-334454-cqaado3u 133 17 later later RB cord-334454-cqaado3u 133 18 can can MD cord-334454-cqaado3u 133 19 be be VB cord-334454-cqaado3u 133 20 considered consider VBN cord-334454-cqaado3u 133 21 in in IN cord-334454-cqaado3u 133 22 routine routine JJ cord-334454-cqaado3u 133 23 clinical clinical JJ cord-334454-cqaado3u 133 24 practice practice NN cord-334454-cqaado3u 133 25 . . . cord-334454-cqaado3u 134 1 Also also RB cord-334454-cqaado3u 134 2 regarding regard VBG cord-334454-cqaado3u 134 3 the the DT cord-334454-cqaado3u 134 4 follow follow NN cord-334454-cqaado3u 134 5 - - HYPH cord-334454-cqaado3u 134 6 up up NN cord-334454-cqaado3u 134 7 and and CC cord-334454-cqaado3u 134 8 life life NN cord-334454-cqaado3u 134 9 span span NN cord-334454-cqaado3u 134 10 , , , cord-334454-cqaado3u 134 11 studies study NNS cord-334454-cqaado3u 134 12 are be VBP cord-334454-cqaado3u 134 13 warranted warrant VBN cord-334454-cqaado3u 134 14 . . . cord-334454-cqaado3u 135 1 In in IN cord-334454-cqaado3u 135 2 fact fact NN cord-334454-cqaado3u 135 3 , , , cord-334454-cqaado3u 135 4 some some DT cord-334454-cqaado3u 135 5 authors author NNS cord-334454-cqaado3u 135 6 have have VBP cord-334454-cqaado3u 135 7 tried try VBN cord-334454-cqaado3u 135 8 to to TO cord-334454-cqaado3u 135 9 perform perform VB cord-334454-cqaado3u 135 10 monthly monthly RB cord-334454-cqaado3u 135 11 to to IN cord-334454-cqaado3u 135 12 trimester trimester NN cord-334454-cqaado3u 135 13 follow follow NN cord-334454-cqaado3u 135 14 - - HYPH cord-334454-cqaado3u 135 15 ups up NNS cord-334454-cqaado3u 135 16 after after IN cord-334454-cqaado3u 135 17 the the DT cord-334454-cqaado3u 135 18 end end NN cord-334454-cqaado3u 135 19 of of IN cord-334454-cqaado3u 135 20 therapy therapy NN cord-334454-cqaado3u 135 21 . . . cord-334454-cqaado3u 136 1 In in IN cord-334454-cqaado3u 136 2 both both DT cord-334454-cqaado3u 136 3 groups group NNS cord-334454-cqaado3u 136 4 , , , cord-334454-cqaado3u 136 5 it -PRON- PRP cord-334454-cqaado3u 136 6 was be VBD cord-334454-cqaado3u 136 7 unsuccessful unsuccessful JJ cord-334454-cqaado3u 136 8 . . . cord-334454-cqaado3u 137 1 In in IN cord-334454-cqaado3u 137 2 the the DT cord-334454-cqaado3u 137 3 animal animal NN cord-334454-cqaado3u 137 4 shelter shelter NN cord-334454-cqaado3u 137 5 , , , cord-334454-cqaado3u 137 6 clinical clinical JJ cord-334454-cqaado3u 137 7 evaluations evaluation NNS cord-334454-cqaado3u 137 8 after after IN cord-334454-cqaado3u 137 9 therapy therapy NN cord-334454-cqaado3u 137 10 were be VBD cord-334454-cqaado3u 137 11 unreasonable unreasonable JJ cord-334454-cqaado3u 137 12 once once IN cord-334454-cqaado3u 137 13 the the DT cord-334454-cqaado3u 137 14 income income NN cord-334454-cqaado3u 137 15 and and CC cord-334454-cqaado3u 137 16 outcome outcome NN cord-334454-cqaado3u 137 17 of of IN cord-334454-cqaado3u 137 18 cats cat NNS cord-334454-cqaado3u 137 19 impaired impair VBD cord-334454-cqaado3u 137 20 correct correct JJ cord-334454-cqaado3u 137 21 conclusions conclusion NNS cord-334454-cqaado3u 137 22 . . . cord-334454-cqaado3u 138 1 Regarding regard VBG cord-334454-cqaado3u 138 2 client client NN cord-334454-cqaado3u 138 3 - - HYPH cord-334454-cqaado3u 138 4 owned own VBN cord-334454-cqaado3u 138 5 cats cat NNS cord-334454-cqaado3u 138 6 , , , cord-334454-cqaado3u 138 7 it -PRON- PRP cord-334454-cqaado3u 138 8 was be VBD cord-334454-cqaado3u 138 9 only only RB cord-334454-cqaado3u 138 10 correctly correctly RB cord-334454-cqaado3u 138 11 achieved achieve VBN cord-334454-cqaado3u 138 12 in in IN cord-334454-cqaado3u 138 13 a a DT cord-334454-cqaado3u 138 14 small small JJ cord-334454-cqaado3u 138 15 number number NN cord-334454-cqaado3u 138 16 of of IN cord-334454-cqaado3u 138 17 treated treat VBN cord-334454-cqaado3u 138 18 animals animal NNS cord-334454-cqaado3u 138 19 ( ( -LRB- cord-334454-cqaado3u 138 20 unpublished unpublished JJ cord-334454-cqaado3u 138 21 data datum NNS cord-334454-cqaado3u 138 22 ) ) -RRB- cord-334454-cqaado3u 138 23 . . . cord-334454-cqaado3u 139 1 In in IN cord-334454-cqaado3u 139 2 fact fact NN cord-334454-cqaado3u 139 3 , , , cord-334454-cqaado3u 139 4 the the DT cord-334454-cqaado3u 139 5 individual individual JJ cord-334454-cqaado3u 139 6 oral oral JJ cord-334454-cqaado3u 139 7 therapy therapy NN cord-334454-cqaado3u 139 8 for for IN cord-334454-cqaado3u 139 9 each each DT cord-334454-cqaado3u 139 10 cat cat NN cord-334454-cqaado3u 139 11 was be VBD cord-334454-cqaado3u 139 12 free free JJ cord-334454-cqaado3u 139 13 of of IN cord-334454-cqaado3u 139 14 charge charge NN cord-334454-cqaado3u 139 15 and and CC cord-334454-cqaado3u 139 16 comprised comprise VBD cord-334454-cqaado3u 139 17 a a DT cord-334454-cqaado3u 139 18 total total NN cord-334454-cqaado3u 139 19 of of IN cord-334454-cqaado3u 139 20 90 90 CD cord-334454-cqaado3u 139 21 daily daily JJ cord-334454-cqaado3u 139 22 doses dose NNS cord-334454-cqaado3u 139 23 that that WDT cord-334454-cqaado3u 139 24 were be VBD cord-334454-cqaado3u 139 25 partially partially RB cord-334454-cqaado3u 139 26 given give VBN cord-334454-cqaado3u 139 27 to to IN cord-334454-cqaado3u 139 28 the the DT cord-334454-cqaado3u 139 29 owners owner NNS cord-334454-cqaado3u 139 30 at at IN cord-334454-cqaado3u 139 31 each each DT cord-334454-cqaado3u 139 32 evaluation evaluation NN cord-334454-cqaado3u 139 33 time time NN cord-334454-cqaado3u 139 34 point point NN cord-334454-cqaado3u 139 35 . . . cord-334454-cqaado3u 140 1 After after IN cord-334454-cqaado3u 140 2 the the DT cord-334454-cqaado3u 140 3 end end NN cord-334454-cqaado3u 140 4 of of IN cord-334454-cqaado3u 140 5 the the DT cord-334454-cqaado3u 140 6 therapy therapy NN cord-334454-cqaado3u 140 7 , , , cord-334454-cqaado3u 140 8 the the DT cord-334454-cqaado3u 140 9 monitoring monitoring NN cord-334454-cqaado3u 140 10 was be VBD cord-334454-cqaado3u 140 11 unpractical unpractical JJ cord-334454-cqaado3u 140 12 once once IN cord-334454-cqaado3u 140 13 the the DT cord-334454-cqaado3u 140 14 majority majority NN cord-334454-cqaado3u 140 15 of of IN cord-334454-cqaado3u 140 16 owners owner NNS cord-334454-cqaado3u 140 17 were be VBD cord-334454-cqaado3u 140 18 unavailable unavailable JJ cord-334454-cqaado3u 140 19 to to IN cord-334454-cqaado3u 140 20 pursuit pursuit NN cord-334454-cqaado3u 140 21 with with IN cord-334454-cqaado3u 140 22 monthly monthly JJ cord-334454-cqaado3u 140 23 follow follow NN cord-334454-cqaado3u 140 24 - - HYPH cord-334454-cqaado3u 140 25 ups up NNS cord-334454-cqaado3u 140 26 . . . cord-334454-cqaado3u 141 1 Consequently consequently RB cord-334454-cqaado3u 141 2 , , , cord-334454-cqaado3u 141 3 a a DT cord-334454-cqaado3u 141 4 structured structured JJ cord-334454-cqaado3u 141 5 prospective prospective JJ cord-334454-cqaado3u 141 6 study study NN cord-334454-cqaado3u 141 7 would would MD cord-334454-cqaado3u 141 8 be be VB cord-334454-cqaado3u 141 9 interesting interesting JJ cord-334454-cqaado3u 141 10 in in IN cord-334454-cqaado3u 141 11 order order NN cord-334454-cqaado3u 141 12 to to TO cord-334454-cqaado3u 141 13 evaluate evaluate VB cord-334454-cqaado3u 141 14 not not RB cord-334454-cqaado3u 141 15 only only RB cord-334454-cqaado3u 141 16 the the DT cord-334454-cqaado3u 141 17 long long JJ cord-334454-cqaado3u 141 18 - - HYPH cord-334454-cqaado3u 141 19 term term NN cord-334454-cqaado3u 141 20 benefits benefit NNS cord-334454-cqaado3u 141 21 of of IN cord-334454-cqaado3u 141 22 therapy therapy NN cord-334454-cqaado3u 141 23 but but CC cord-334454-cqaado3u 141 24 also also RB cord-334454-cqaado3u 141 25 any any DT cord-334454-cqaado3u 141 26 effect effect NN cord-334454-cqaado3u 141 27 on on IN cord-334454-cqaado3u 141 28 the the DT cord-334454-cqaado3u 141 29 mean mean JJ cord-334454-cqaado3u 141 30 life life NN cord-334454-cqaado3u 141 31 span span NN cord-334454-cqaado3u 141 32 of of IN cord-334454-cqaado3u 141 33 FIV fiv NN cord-334454-cqaado3u 141 34 - - HYPH cord-334454-cqaado3u 141 35 infected infect VBN cord-334454-cqaado3u 141 36 cats cat NNS cord-334454-cqaado3u 141 37 . . . cord-334454-cqaado3u 142 1 These these DT cord-334454-cqaado3u 142 2 studies study NNS cord-334454-cqaado3u 142 3 innovated innovate VBD cord-334454-cqaado3u 142 4 in in IN cord-334454-cqaado3u 142 5 the the DT cord-334454-cqaado3u 142 6 extension extension NN cord-334454-cqaado3u 142 7 of of IN cord-334454-cqaado3u 142 8 the the DT cord-334454-cqaado3u 142 9 main main JJ cord-334454-cqaado3u 142 10 therapeutic therapeutic JJ cord-334454-cqaado3u 142 11 properties property NNS cord-334454-cqaado3u 142 12 of of IN cord-334454-cqaado3u 142 13 the the DT cord-334454-cqaado3u 142 14 licensed licensed JJ cord-334454-cqaado3u 142 15 rFeIFN rfeifn NN cord-334454-cqaado3u 142 16 - - HYPH cord-334454-cqaado3u 142 17 ω ω CD cord-334454-cqaado3u 142 18 protocol protocol NN cord-334454-cqaado3u 142 19 in in IN cord-334454-cqaado3u 142 20 naturally naturally RB cord-334454-cqaado3u 142 21 retrovirally retrovirally NN cord-334454-cqaado3u 142 22 infected infected JJ cord-334454-cqaado3u 142 23 cats cat NNS cord-334454-cqaado3u 142 24 . . . cord-334454-cqaado3u 143 1 It -PRON- PRP cord-334454-cqaado3u 143 2 is be VBZ cord-334454-cqaado3u 143 3 now now RB cord-334454-cqaado3u 143 4 documented document VBN cord-334454-cqaado3u 143 5 that that IN cord-334454-cqaado3u 143 6 it -PRON- PRP cord-334454-cqaado3u 143 7 must must MD cord-334454-cqaado3u 143 8 be be VB cord-334454-cqaado3u 143 9 used use VBN cord-334454-cqaado3u 143 10 not not RB cord-334454-cqaado3u 143 11 only only RB cord-334454-cqaado3u 143 12 in in IN cord-334454-cqaado3u 143 13 client client NN cord-334454-cqaado3u 143 14 - - HYPH cord-334454-cqaado3u 143 15 owned own VBN cord-334454-cqaado3u 143 16 symptomatic symptomatic JJ cord-334454-cqaado3u 143 17 cats cat NNS cord-334454-cqaado3u 143 18 but but CC cord-334454-cqaado3u 143 19 also also RB cord-334454-cqaado3u 143 20 in in IN cord-334454-cqaado3u 143 21 animals animal NNS cord-334454-cqaado3u 143 22 living live VBG cord-334454-cqaado3u 143 23 in in IN cord-334454-cqaado3u 143 24 catteries catterie NNS cord-334454-cqaado3u 143 25 or or CC cord-334454-cqaado3u 143 26 shelters shelter NNS cord-334454-cqaado3u 143 27 where where WRB cord-334454-cqaado3u 143 28 opportunistic opportunistic JJ cord-334454-cqaado3u 143 29 infections infection NNS cord-334454-cqaado3u 143 30 are be VBP cord-334454-cqaado3u 143 31 problematic problematic JJ cord-334454-cqaado3u 143 32 . . . cord-334454-cqaado3u 144 1 Although although IN cord-334454-cqaado3u 144 2 without without IN cord-334454-cqaado3u 144 3 a a DT cord-334454-cqaado3u 144 4 truly truly RB cord-334454-cqaado3u 144 5 effect effect NN cord-334454-cqaado3u 144 6 on on IN cord-334454-cqaado3u 144 7 the the DT cord-334454-cqaado3u 144 8 cytokine cytokine NN cord-334454-cqaado3u 144 9 profile profile NN cord-334454-cqaado3u 144 10 , , , cord-334454-cqaado3u 144 11 this this DT cord-334454-cqaado3u 144 12 compound compound NN cord-334454-cqaado3u 144 13 induces induce VBZ cord-334454-cqaado3u 144 14 a a DT cord-334454-cqaado3u 144 15 significant significant JJ cord-334454-cqaado3u 144 16 clinical clinical JJ cord-334454-cqaado3u 144 17 improvement improvement NN cord-334454-cqaado3u 144 18 and and CC cord-334454-cqaado3u 144 19 seems seem VBZ cord-334454-cqaado3u 144 20 to to TO cord-334454-cqaado3u 144 21 reduce reduce VB cord-334454-cqaado3u 144 22 the the DT cord-334454-cqaado3u 144 23 pro pro JJ cord-334454-cqaado3u 144 24 - - JJ cord-334454-cqaado3u 144 25 inflammatory inflammatory JJ cord-334454-cqaado3u 144 26 stimuli stimulus NNS cord-334454-cqaado3u 144 27 . . . cord-334454-cqaado3u 145 1 Particularly particularly RB cord-334454-cqaado3u 145 2 , , , cord-334454-cqaado3u 145 3 for for IN cord-334454-cqaado3u 145 4 FIV fiv NN cord-334454-cqaado3u 145 5 - - HYPH cord-334454-cqaado3u 145 6 infected infect VBN cord-334454-cqaado3u 145 7 cats cat NNS cord-334454-cqaado3u 145 8 , , , cord-334454-cqaado3u 145 9 this this DT cord-334454-cqaado3u 145 10 work work NN cord-334454-cqaado3u 145 11 presents present VBZ cord-334454-cqaado3u 145 12 a a DT cord-334454-cqaado3u 145 13 new new JJ cord-334454-cqaado3u 145 14 oral oral JJ cord-334454-cqaado3u 145 15 rFeIFN rfeifn NN cord-334454-cqaado3u 145 16 - - HYPH cord-334454-cqaado3u 145 17 ω ω CD cord-334454-cqaado3u 145 18 protocol protocol NN cord-334454-cqaado3u 145 19 , , , cord-334454-cqaado3u 145 20 which which WDT cord-334454-cqaado3u 145 21 was be VBD cord-334454-cqaado3u 145 22 successfully successfully RB cord-334454-cqaado3u 145 23 tested test VBN cord-334454-cqaado3u 145 24 and and CC cord-334454-cqaado3u 145 25 validated validate VBN cord-334454-cqaado3u 145 26 . . . cord-334454-cqaado3u 146 1 Although although IN cord-334454-cqaado3u 146 2 it -PRON- PRP cord-334454-cqaado3u 146 3 induces induce VBZ cord-334454-cqaado3u 146 4 a a DT cord-334454-cqaado3u 146 5 significant significant JJ cord-334454-cqaado3u 146 6 clinical clinical JJ cord-334454-cqaado3u 146 7 improvement improvement NN cord-334454-cqaado3u 146 8 , , , cord-334454-cqaado3u 146 9 its -PRON- PRP$ cord-334454-cqaado3u 146 10 overall overall JJ cord-334454-cqaado3u 146 11 action action NN cord-334454-cqaado3u 146 12 as as IN cord-334454-cqaado3u 146 13 an an DT cord-334454-cqaado3u 146 14 immune immune JJ cord-334454-cqaado3u 146 15 modulator modulator NN cord-334454-cqaado3u 146 16 is be VBZ cord-334454-cqaado3u 146 17 less less JJR cord-334454-cqaado3u 146 18 than than IN cord-334454-cqaado3u 146 19 the the DT cord-334454-cqaado3u 146 20 subcutaneous subcutaneous JJ cord-334454-cqaado3u 146 21 protocol protocol NN cord-334454-cqaado3u 146 22 . . . cord-334454-cqaado3u 147 1 In in IN cord-334454-cqaado3u 147 2 fact fact NN cord-334454-cqaado3u 147 3 , , , cord-334454-cqaado3u 147 4 it -PRON- PRP cord-334454-cqaado3u 147 5 slightly slightly RB cord-334454-cqaado3u 147 6 decreases decrease VBZ cord-334454-cqaado3u 147 7 the the DT cord-334454-cqaado3u 147 8 pro pro JJ cord-334454-cqaado3u 147 9 - - JJ cord-334454-cqaado3u 147 10 inflammatory inflammatory JJ cord-334454-cqaado3u 147 11 stimuli stimulus NNS cord-334454-cqaado3u 147 12 without without IN cord-334454-cqaado3u 147 13 affecting affect VBG cord-334454-cqaado3u 147 14 the the DT cord-334454-cqaado3u 147 15 acquired acquire VBN cord-334454-cqaado3u 147 16 immunity immunity NN cord-334454-cqaado3u 147 17 , , , cord-334454-cqaado3u 147 18 or or CC cord-334454-cqaado3u 147 19 even even RB cord-334454-cqaado3u 147 20 other other JJ cord-334454-cqaado3u 147 21 parameters parameter NNS cord-334454-cqaado3u 147 22 of of IN cord-334454-cqaado3u 147 23 the the DT cord-334454-cqaado3u 147 24 innate innate JJ cord-334454-cqaado3u 147 25 response response NN cord-334454-cqaado3u 147 26 such such JJ cord-334454-cqaado3u 147 27 as as IN cord-334454-cqaado3u 147 28 acute acute JJ cord-334454-cqaado3u 147 29 phase phase NN cord-334454-cqaado3u 147 30 proteins protein NNS cord-334454-cqaado3u 147 31 . . . cord-334454-cqaado3u 148 1 Therefore therefore RB cord-334454-cqaado3u 148 2 , , , cord-334454-cqaado3u 148 3 whilst whilst IN cord-334454-cqaado3u 148 4 the the DT cord-334454-cqaado3u 148 5 high high JJ cord-334454-cqaado3u 148 6 pulsate pulsate VBP cord-334454-cqaado3u 148 7 subcutaneous subcutaneous JJ cord-334454-cqaado3u 148 8 protocol protocol NN cord-334454-cqaado3u 148 9 is be VBZ cord-334454-cqaado3u 148 10 strongly strongly RB cord-334454-cqaado3u 148 11 recommended recommend VBN cord-334454-cqaado3u 148 12 for for IN cord-334454-cqaado3u 148 13 symptomatic symptomatic JJ cord-334454-cqaado3u 148 14 FIV fiv NN cord-334454-cqaado3u 148 15 - - HYPH cord-334454-cqaado3u 148 16 infected infect VBN cord-334454-cqaado3u 148 17 cats cat NNS cord-334454-cqaado3u 148 18 , , , cord-334454-cqaado3u 148 19 this this DT cord-334454-cqaado3u 148 20 lower lower RBR cord-334454-cqaado3u 148 21 continuous continuous JJ cord-334454-cqaado3u 148 22 oral oral JJ cord-334454-cqaado3u 148 23 protocol protocol NN cord-334454-cqaado3u 148 24 is be VBZ cord-334454-cqaado3u 148 25 a a DT cord-334454-cqaado3u 148 26 good good JJ cord-334454-cqaado3u 148 27 alternative alternative NN cord-334454-cqaado3u 148 28 for for IN cord-334454-cqaado3u 148 29 cats cat NNS cord-334454-cqaado3u 148 30 presenting present VBG cord-334454-cqaado3u 148 31 mild mild JJ cord-334454-cqaado3u 148 32 clinical clinical JJ cord-334454-cqaado3u 148 33 signs sign NNS cord-334454-cqaado3u 148 34 , , , cord-334454-cqaado3u 148 35 for for IN cord-334454-cqaado3u 148 36 cases case NNS cord-334454-cqaado3u 148 37 where where WRB cord-334454-cqaado3u 148 38 cost cost NN cord-334454-cqaado3u 148 39 limits limit NNS cord-334454-cqaado3u 148 40 the the DT cord-334454-cqaado3u 148 41 use use NN cord-334454-cqaado3u 148 42 of of IN cord-334454-cqaado3u 148 43 licensed licensed JJ cord-334454-cqaado3u 148 44 protocol protocol NN cord-334454-cqaado3u 148 45 or or CC cord-334454-cqaado3u 148 46 even even RB cord-334454-cqaado3u 148 47 for for IN cord-334454-cqaado3u 148 48 cats cat NNS cord-334454-cqaado3u 148 49 , , , cord-334454-cqaado3u 148 50 which which WDT cord-334454-cqaado3u 148 51 previously previously RB cord-334454-cqaado3u 148 52 received receive VBD cord-334454-cqaado3u 148 53 subcutaneous subcutaneous JJ cord-334454-cqaado3u 148 54 rFeIFN rfeifn NN cord-334454-cqaado3u 148 55 - - HYPH cord-334454-cqaado3u 148 56 ω ω JJS cord-334454-cqaado3u 148 57 and and CC cord-334454-cqaado3u 148 58 require require VB cord-334454-cqaado3u 148 59 continuous continuous JJ cord-334454-cqaado3u 148 60 immune immune JJ cord-334454-cqaado3u 148 61 modulation modulation NN cord-334454-cqaado3u 148 62 therapy therapy NN cord-334454-cqaado3u 148 63 . . . cord-334454-cqaado3u 149 1 These these DT cord-334454-cqaado3u 149 2 studies study NNS cord-334454-cqaado3u 149 3 did do VBD cord-334454-cqaado3u 149 4 not not RB cord-334454-cqaado3u 149 5 contribute contribute VB cord-334454-cqaado3u 149 6 to to IN cord-334454-cqaado3u 149 7 a a DT cord-334454-cqaado3u 149 8 better well JJR cord-334454-cqaado3u 149 9 understanding understanding NN cord-334454-cqaado3u 149 10 of of IN cord-334454-cqaado3u 149 11 rFeIFN rfeifn NN cord-334454-cqaado3u 149 12 - - HYPH cord-334454-cqaado3u 149 13 ω ω JJ cord-334454-cqaado3u 149 14 as as RB cord-334454-cqaado3u 149 15 much much RB cord-334454-cqaado3u 149 16 as as IN cord-334454-cqaado3u 149 17 they -PRON- PRP cord-334454-cqaado3u 149 18 explored explore VBD cord-334454-cqaado3u 149 19 its -PRON- PRP$ cord-334454-cqaado3u 149 20 immune immune JJ cord-334454-cqaado3u 149 21 modulation modulation NN cord-334454-cqaado3u 149 22 properties property NNS cord-334454-cqaado3u 149 23 and and CC cord-334454-cqaado3u 149 24 validated validate VBD cord-334454-cqaado3u 149 25 a a DT cord-334454-cqaado3u 149 26 new new JJ cord-334454-cqaado3u 149 27 oral oral JJ cord-334454-cqaado3u 149 28 protocol protocol NN cord-334454-cqaado3u 149 29 , , , cord-334454-cqaado3u 149 30 which which WDT cord-334454-cqaado3u 149 31 can can MD cord-334454-cqaado3u 149 32 be be VB cord-334454-cqaado3u 149 33 included include VBN cord-334454-cqaado3u 149 34 in in IN cord-334454-cqaado3u 149 35 future future JJ cord-334454-cqaado3u 149 36 FIV fiv NN cord-334454-cqaado3u 149 37 - - HYPH cord-334454-cqaado3u 149 38 guidelines guideline NNS cord-334454-cqaado3u 149 39 . . . cord-334454-cqaado3u 150 1 In in IN cord-334454-cqaado3u 150 2 summary summary NN cord-334454-cqaado3u 150 3 , , , cord-334454-cqaado3u 150 4 this this DT cord-334454-cqaado3u 150 5 review review NN cord-334454-cqaado3u 150 6 reinforces reinforce VBZ cord-334454-cqaado3u 150 7 the the DT cord-334454-cqaado3u 150 8 beneficial beneficial JJ cord-334454-cqaado3u 150 9 properties property NNS cord-334454-cqaado3u 150 10 of of IN cord-334454-cqaado3u 150 11 IFN IFN NNP cord-334454-cqaado3u 150 12 therapy therapy NN cord-334454-cqaado3u 150 13 opening open VBG cord-334454-cqaado3u 150 14 new new JJ cord-334454-cqaado3u 150 15 perspectives perspective NNS cord-334454-cqaado3u 150 16 for for IN cord-334454-cqaado3u 150 17 its -PRON- PRP$ cord-334454-cqaado3u 150 18 use use NN cord-334454-cqaado3u 150 19 in in IN cord-334454-cqaado3u 150 20 retroviral retroviral JJ cord-334454-cqaado3u 150 21 infections infection NNS cord-334454-cqaado3u 150 22 . . . cord-334454-cqaado3u 151 1 Even even RB cord-334454-cqaado3u 151 2 if if IN cord-334454-cqaado3u 151 3 rFeIFN rfeifn NN cord-334454-cqaado3u 151 4 - - HYPH cord-334454-cqaado3u 151 5 ω ω NN cord-334454-cqaado3u 151 6 is be VBZ cord-334454-cqaado3u 151 7 a a DT cord-334454-cqaado3u 151 8 species species NN cord-334454-cqaado3u 151 9 - - HYPH cord-334454-cqaado3u 151 10 specific specific JJ cord-334454-cqaado3u 151 11 compound compound NN cord-334454-cqaado3u 151 12 , , , cord-334454-cqaado3u 151 13 these these DT cord-334454-cqaado3u 151 14 conclusions conclusion NNS cord-334454-cqaado3u 151 15 can can MD cord-334454-cqaado3u 151 16 be be VB cord-334454-cqaado3u 151 17 extrapolated extrapolate VBN cord-334454-cqaado3u 151 18 to to IN cord-334454-cqaado3u 151 19 a a DT cord-334454-cqaado3u 151 20 larger large JJR cord-334454-cqaado3u 151 21 perspective perspective NN cord-334454-cqaado3u 151 22 . . . cord-334454-cqaado3u 152 1 Either either CC cord-334454-cqaado3u 152 2 in in IN cord-334454-cqaado3u 152 3 FIV fiv NN cord-334454-cqaado3u 152 4 - - HYPH cord-334454-cqaado3u 152 5 infected infect VBN cord-334454-cqaado3u 152 6 cats cat NNS cord-334454-cqaado3u 152 7 or or CC cord-334454-cqaado3u 152 8 in in IN cord-334454-cqaado3u 152 9 HIV HIV NNP cord-334454-cqaado3u 152 10 individuals individual NNS cord-334454-cqaado3u 152 11 , , , cord-334454-cqaado3u 152 12 type type NN cord-334454-cqaado3u 152 13 I -PRON- PRP cord-334454-cqaado3u 152 14 IFNs ifns VBP cord-334454-cqaado3u 152 15 seem seem VBP cord-334454-cqaado3u 152 16 to to TO cord-334454-cqaado3u 152 17 induce induce VB cord-334454-cqaado3u 152 18 an an DT cord-334454-cqaado3u 152 19 innate innate JJ cord-334454-cqaado3u 152 20 immune immune JJ cord-334454-cqaado3u 152 21 - - HYPH cord-334454-cqaado3u 152 22 modulation modulation NN cord-334454-cqaado3u 152 23 and and CC cord-334454-cqaado3u 152 24 should should MD cord-334454-cqaado3u 152 25 not not RB cord-334454-cqaado3u 152 26 be be VB cord-334454-cqaado3u 152 27 overlooked overlook VBN cord-334454-cqaado3u 152 28 as as IN cord-334454-cqaado3u 152 29 a a DT cord-334454-cqaado3u 152 30 therapeutic therapeutic JJ cord-334454-cqaado3u 152 31 option option NN cord-334454-cqaado3u 152 32 in in IN cord-334454-cqaado3u 152 33 retroviral retroviral JJ cord-334454-cqaado3u 152 34 infections infection NNS cord-334454-cqaado3u 152 35 . . . cord-334454-cqaado3u 153 1 Clinical clinical JJ cord-334454-cqaado3u 153 2 aspects aspect NNS cord-334454-cqaado3u 153 3 of of IN cord-334454-cqaado3u 153 4 feline feline JJ cord-334454-cqaado3u 153 5 retroviruses retrovirus NNS cord-334454-cqaado3u 153 6 : : : cord-334454-cqaado3u 153 7 A a DT cord-334454-cqaado3u 153 8 review review NN cord-334454-cqaado3u 153 9 Clinical clinical JJ cord-334454-cqaado3u 153 10 aspects aspect NNS cord-334454-cqaado3u 153 11 of of IN cord-334454-cqaado3u 153 12 feline feline JJ cord-334454-cqaado3u 153 13 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 153 14 and and CC cord-334454-cqaado3u 153 15 feline feline JJ cord-334454-cqaado3u 153 16 leukemia leukemia NN cord-334454-cqaado3u 153 17 virus virus NN cord-334454-cqaado3u 153 18 infection infection NN cord-334454-cqaado3u 153 19 Efficacy Efficacy NNP cord-334454-cqaado3u 153 20 of of IN cord-334454-cqaado3u 153 21 antiviral antiviral JJ cord-334454-cqaado3u 153 22 chemotherapy chemotherapy NN cord-334454-cqaado3u 153 23 for for IN cord-334454-cqaado3u 153 24 retrovirus retrovirus NN cord-334454-cqaado3u 153 25 - - HYPH cord-334454-cqaado3u 153 26 infected infect VBN cord-334454-cqaado3u 153 27 cats cat NNS cord-334454-cqaado3u 153 28 : : : cord-334454-cqaado3u 153 29 What what WP cord-334454-cqaado3u 153 30 does do VBZ cord-334454-cqaado3u 153 31 the the DT cord-334454-cqaado3u 153 32 current current JJ cord-334454-cqaado3u 153 33 literature literature NN cord-334454-cqaado3u 153 34 tell tell VB cord-334454-cqaado3u 153 35 us -PRON- PRP cord-334454-cqaado3u 153 36 ? ? . cord-334454-cqaado3u 154 1 Chapter chapter NN cord-334454-cqaado3u 154 2 2 2 CD cord-334454-cqaado3u 154 3 : : : cord-334454-cqaado3u 155 1 Antiviral antiviral JJ cord-334454-cqaado3u 155 2 and and CC cord-334454-cqaado3u 155 3 Immmunomodulatory Immmunomodulatory NNP cord-334454-cqaado3u 155 4 Chemotherapy Chemotherapy NNP cord-334454-cqaado3u 155 5 Interferon Interferon NNP cord-334454-cqaado3u 155 6 - - HYPH cord-334454-cqaado3u 155 7 inducible inducible JJ cord-334454-cqaado3u 155 8 antiviral antiviral JJ cord-334454-cqaado3u 155 9 effectors effector NNS cord-334454-cqaado3u 156 1 IFN IFN NNP cord-334454-cqaado3u 156 2 - - HYPH cord-334454-cqaado3u 156 3 alpha alpha NN cord-334454-cqaado3u 156 4 regulates regulate VBZ cord-334454-cqaado3u 156 5 TLR TLR NNP cord-334454-cqaado3u 156 6 - - HYPH cord-334454-cqaado3u 156 7 dependent dependent JJ cord-334454-cqaado3u 156 8 gene gene NN cord-334454-cqaado3u 156 9 expression expression NN cord-334454-cqaado3u 156 10 of of IN cord-334454-cqaado3u 156 11 IFN IFN NNP cord-334454-cqaado3u 156 12 - - HYPH cord-334454-cqaado3u 156 13 alpha alpha NN cord-334454-cqaado3u 156 14 , , , cord-334454-cqaado3u 156 15 IFN IFN NNP cord-334454-cqaado3u 156 16 - - HYPH cord-334454-cqaado3u 156 17 beta beta NN cord-334454-cqaado3u 156 18 , , , cord-334454-cqaado3u 156 19 IL-28 IL-28 NNP cord-334454-cqaado3u 156 20 , , , cord-334454-cqaado3u 156 21 and and CC cord-334454-cqaado3u 156 22 IL-29 IL-29 NNP cord-334454-cqaado3u 156 23 Plasmacytoid Plasmacytoid NNP cord-334454-cqaado3u 156 24 dendritic dendritic JJ cord-334454-cqaado3u 156 25 cells cell NNS cord-334454-cqaado3u 156 26 in in IN cord-334454-cqaado3u 156 27 immunity immunity NN cord-334454-cqaado3u 156 28 Activity activity NN cord-334454-cqaado3u 156 29 of of IN cord-334454-cqaado3u 156 30 feline feline JJ cord-334454-cqaado3u 156 31 interferon interferon NN cord-334454-cqaado3u 156 32 - - HYPH cord-334454-cqaado3u 156 33 omega omega NN cord-334454-cqaado3u 156 34 after after IN cord-334454-cqaado3u 156 35 ocular ocular JJ cord-334454-cqaado3u 156 36 or or CC cord-334454-cqaado3u 156 37 oral oral JJ cord-334454-cqaado3u 156 38 administration administration NN cord-334454-cqaado3u 156 39 in in IN cord-334454-cqaado3u 156 40 cats cat NNS cord-334454-cqaado3u 156 41 as as IN cord-334454-cqaado3u 156 42 indicated indicate VBN cord-334454-cqaado3u 156 43 by by IN cord-334454-cqaado3u 156 44 Mx Mx NNP cord-334454-cqaado3u 156 45 protein protein NN cord-334454-cqaado3u 156 46 expression expression NN cord-334454-cqaado3u 156 47 in in IN cord-334454-cqaado3u 156 48 conjunctival conjunctival NN cord-334454-cqaado3u 156 49 and and CC cord-334454-cqaado3u 156 50 white white JJ cord-334454-cqaado3u 156 51 blood blood NN cord-334454-cqaado3u 156 52 cells cell NNS cord-334454-cqaado3u 156 53 Interferons interferon NNS cord-334454-cqaado3u 156 54 : : : cord-334454-cqaado3u 156 55 Cell cell NN cord-334454-cqaado3u 156 56 signalling signalling NN cord-334454-cqaado3u 156 57 , , , cord-334454-cqaado3u 156 58 immune immune JJ cord-334454-cqaado3u 156 59 modulation modulation NN cord-334454-cqaado3u 156 60 , , , cord-334454-cqaado3u 156 61 antiviral antiviral JJ cord-334454-cqaado3u 156 62 response response NN cord-334454-cqaado3u 156 63 and and CC cord-334454-cqaado3u 156 64 virus virus NN cord-334454-cqaado3u 156 65 countermeasures countermeasure NNS cord-334454-cqaado3u 156 66 Type type NN cord-334454-cqaado3u 157 1 I -PRON- PRP cord-334454-cqaado3u 158 1 interferon interferon NN cord-334454-cqaado3u 158 2 responses response NNS cord-334454-cqaado3u 158 3 in in IN cord-334454-cqaado3u 158 4 rhesus rhesu NNS cord-334454-cqaado3u 158 5 macaques macaque NNS cord-334454-cqaado3u 158 6 prevent prevent VBP cord-334454-cqaado3u 158 7 SIV SIV NNP cord-334454-cqaado3u 158 8 infection infection NN cord-334454-cqaado3u 158 9 and and CC cord-334454-cqaado3u 158 10 slow slow JJ cord-334454-cqaado3u 158 11 disease disease NN cord-334454-cqaado3u 158 12 progression progression NN cord-334454-cqaado3u 158 13 HIV-1 HIV-1 NNP cord-334454-cqaado3u 158 14 and and CC cord-334454-cqaado3u 158 15 interferons interferon NNS cord-334454-cqaado3u 158 16 : : : cord-334454-cqaado3u 159 1 Who who WP cord-334454-cqaado3u 159 2 's be VBZ cord-334454-cqaado3u 159 3 interfering interfere VBG cord-334454-cqaado3u 159 4 with with IN cord-334454-cqaado3u 159 5 whom whom WP cord-334454-cqaado3u 159 6 ? ? . cord-334454-cqaado3u 160 1 APOBEC3 APOBEC3 NNP cord-334454-cqaado3u 161 1 G g NN cord-334454-cqaado3u 161 2 upregulation upregulation NN cord-334454-cqaado3u 161 3 by by IN cord-334454-cqaado3u 161 4 alpha alpha NN cord-334454-cqaado3u 161 5 interferon interferon NN cord-334454-cqaado3u 161 6 restricts restrict VBZ cord-334454-cqaado3u 161 7 human human JJ cord-334454-cqaado3u 161 8 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 161 9 virus virus NN cord-334454-cqaado3u 161 10 type type NN cord-334454-cqaado3u 161 11 1 1 CD cord-334454-cqaado3u 161 12 infection infection NN cord-334454-cqaado3u 161 13 in in IN cord-334454-cqaado3u 161 14 human human JJ cord-334454-cqaado3u 161 15 peripheral peripheral JJ cord-334454-cqaado3u 161 16 plasmacytoid plasmacytoid NNP cord-334454-cqaado3u 161 17 dendritic dendritic JJ cord-334454-cqaado3u 161 18 cells cell NNS cord-334454-cqaado3u 162 1 HIV HIV NNP cord-334454-cqaado3u 162 2 replication replication NN cord-334454-cqaado3u 162 3 can can MD cord-334454-cqaado3u 162 4 be be VB cord-334454-cqaado3u 162 5 blocked block VBN cord-334454-cqaado3u 162 6 by by IN cord-334454-cqaado3u 162 7 recombinant recombinant JJ cord-334454-cqaado3u 162 8 human human JJ cord-334454-cqaado3u 162 9 interferon interferon NN cord-334454-cqaado3u 162 10 beta beta NN cord-334454-cqaado3u 162 11 Cohorts Cohorts NNPS cord-334454-cqaado3u 162 12 for for IN cord-334454-cqaado3u 162 13 the the DT cord-334454-cqaado3u 162 14 study study NN cord-334454-cqaado3u 162 15 of of IN cord-334454-cqaado3u 162 16 HIV-1-exposed hiv-1-exposed JJ cord-334454-cqaado3u 162 17 but but CC cord-334454-cqaado3u 162 18 uninfected uninfected JJ cord-334454-cqaado3u 162 19 individuals individual NNS cord-334454-cqaado3u 162 20 : : : cord-334454-cqaado3u 162 21 Benefits benefit NNS cord-334454-cqaado3u 162 22 and and CC cord-334454-cqaado3u 162 23 limitations limitation NNS cord-334454-cqaado3u 162 24 Interferon Interferon NNP cord-334454-cqaado3u 162 25 responses response NNS cord-334454-cqaado3u 162 26 in in IN cord-334454-cqaado3u 162 27 HIV HIV NNP cord-334454-cqaado3u 162 28 infection infection NN cord-334454-cqaado3u 162 29 : : : cord-334454-cqaado3u 162 30 From from IN cord-334454-cqaado3u 162 31 protection protection NN cord-334454-cqaado3u 162 32 to to IN cord-334454-cqaado3u 162 33 disease disease NN cord-334454-cqaado3u 162 34 Pegylated pegylate VBN cord-334454-cqaado3u 163 1 Interferon interferon NN cord-334454-cqaado3u 164 1 alfa-2a alfa-2a NNP cord-334454-cqaado3u 164 2 monotherapy monotherapy NN cord-334454-cqaado3u 164 3 results result VBZ cord-334454-cqaado3u 164 4 in in IN cord-334454-cqaado3u 164 5 suppression suppression NN cord-334454-cqaado3u 164 6 of of IN cord-334454-cqaado3u 164 7 HIV HIV NNP cord-334454-cqaado3u 164 8 type type NN cord-334454-cqaado3u 164 9 1 1 CD cord-334454-cqaado3u 164 10 replication replication NN cord-334454-cqaado3u 164 11 and and CC cord-334454-cqaado3u 164 12 decreased decrease VBD cord-334454-cqaado3u 164 13 cell cell NN cord-334454-cqaado3u 164 14 - - HYPH cord-334454-cqaado3u 164 15 associated associate VBN cord-334454-cqaado3u 164 16 HIV HIV NNP cord-334454-cqaado3u 164 17 DNA dna NN cord-334454-cqaado3u 164 18 integration integration NN cord-334454-cqaado3u 164 19 Use use NN cord-334454-cqaado3u 164 20 of of IN cord-334454-cqaado3u 164 21 recombinant recombinant JJ cord-334454-cqaado3u 164 22 interferon interferon NN cord-334454-cqaado3u 164 23 omega omega NN cord-334454-cqaado3u 164 24 in in IN cord-334454-cqaado3u 164 25 feline feline JJ cord-334454-cqaado3u 164 26 retrovirosis retrovirosis NN cord-334454-cqaado3u 164 27 : : : cord-334454-cqaado3u 164 28 From from IN cord-334454-cqaado3u 164 29 theory theory NN cord-334454-cqaado3u 164 30 to to TO cord-334454-cqaado3u 164 31 practice practice VB cord-334454-cqaado3u 164 32 Therapeutic therapeutic JJ cord-334454-cqaado3u 164 33 effects effect NNS cord-334454-cqaado3u 164 34 of of IN cord-334454-cqaado3u 164 35 recombinant recombinant JJ cord-334454-cqaado3u 164 36 feline feline JJ cord-334454-cqaado3u 164 37 interferon interferon NN cord-334454-cqaado3u 164 38 - - HYPH cord-334454-cqaado3u 164 39 omega omega NN cord-334454-cqaado3u 164 40 on on IN cord-334454-cqaado3u 164 41 feline feline JJ cord-334454-cqaado3u 164 42 leukemia leukemia NN cord-334454-cqaado3u 164 43 virus virus NN cord-334454-cqaado3u 164 44 ( ( -LRB- cord-334454-cqaado3u 164 45 FeLV)-infected felv)-infecte VBN cord-334454-cqaado3u 164 46 and and CC cord-334454-cqaado3u 164 47 FeLV FeLV NNP cord-334454-cqaado3u 164 48 / / SYM cord-334454-cqaado3u 164 49 feline feline JJ cord-334454-cqaado3u 164 50 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 164 51 virus virus NN cord-334454-cqaado3u 164 52 ( ( -LRB- cord-334454-cqaado3u 164 53 FIV)-coinfected fiv)-coinfecte VBN cord-334454-cqaado3u 164 54 symptomatic symptomatic JJ cord-334454-cqaado3u 164 55 cats cat NNS cord-334454-cqaado3u 164 56 Immunomodulation Immunomodulation NNP cord-334454-cqaado3u 164 57 and and CC cord-334454-cqaado3u 164 58 therapeutic therapeutic JJ cord-334454-cqaado3u 164 59 effects effect NNS cord-334454-cqaado3u 164 60 of of IN cord-334454-cqaado3u 164 61 the the DT cord-334454-cqaado3u 164 62 oral oral JJ cord-334454-cqaado3u 164 63 use use NN cord-334454-cqaado3u 164 64 of of IN cord-334454-cqaado3u 164 65 interferon interferon NN cord-334454-cqaado3u 164 66 - - HYPH cord-334454-cqaado3u 164 67 alpha alpha NN cord-334454-cqaado3u 164 68 : : : cord-334454-cqaado3u 164 69 Mechanism mechanism NN cord-334454-cqaado3u 164 70 of of IN cord-334454-cqaado3u 164 71 action action NN cord-334454-cqaado3u 164 72 Susceptibility susceptibility NN cord-334454-cqaado3u 164 73 of of IN cord-334454-cqaado3u 164 74 feline feline JJ cord-334454-cqaado3u 164 75 herpesvirus herpesvirus NN cord-334454-cqaado3u 164 76 1 1 CD cord-334454-cqaado3u 164 77 and and CC cord-334454-cqaado3u 164 78 a a DT cord-334454-cqaado3u 164 79 feline feline JJ cord-334454-cqaado3u 164 80 calicivirus calicivirus NN cord-334454-cqaado3u 164 81 to to IN cord-334454-cqaado3u 164 82 feline feline JJ cord-334454-cqaado3u 164 83 interferon interferon NN cord-334454-cqaado3u 164 84 and and CC cord-334454-cqaado3u 164 85 recombinant recombinant JJ cord-334454-cqaado3u 164 86 human human JJ cord-334454-cqaado3u 164 87 leukocyte leukocyte NN cord-334454-cqaado3u 164 88 interferons interferon NNS cord-334454-cqaado3u 164 89 Low low JJ cord-334454-cqaado3u 164 90 - - HYPH cord-334454-cqaado3u 164 91 dose dose NN cord-334454-cqaado3u 164 92 interferon interferon NN cord-334454-cqaado3u 164 93 - - HYPH cord-334454-cqaado3u 164 94 alpha alpha NN cord-334454-cqaado3u 164 95 treatment treatment NN cord-334454-cqaado3u 164 96 for for IN cord-334454-cqaado3u 164 97 feline feline JJ cord-334454-cqaado3u 164 98 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 164 99 virus virus NN cord-334454-cqaado3u 164 100 infection infection NN cord-334454-cqaado3u 164 101 Inhibitory inhibitory JJ cord-334454-cqaado3u 164 102 effects effect NNS cord-334454-cqaado3u 164 103 of of IN cord-334454-cqaado3u 164 104 ribavirin ribavirin NN cord-334454-cqaado3u 164 105 alone alone RB cord-334454-cqaado3u 164 106 or or CC cord-334454-cqaado3u 164 107 combined combine VBN cord-334454-cqaado3u 164 108 with with IN cord-334454-cqaado3u 164 109 human human JJ cord-334454-cqaado3u 164 110 alpha alpha NN cord-334454-cqaado3u 164 111 interferon interferon NN cord-334454-cqaado3u 164 112 on on IN cord-334454-cqaado3u 164 113 feline feline JJ cord-334454-cqaado3u 164 114 infectious infectious JJ cord-334454-cqaado3u 164 115 peritonitis peritonitis NN cord-334454-cqaado3u 164 116 virus virus NN cord-334454-cqaado3u 164 117 replication replication NN cord-334454-cqaado3u 164 118 in in IN cord-334454-cqaado3u 164 119 vitro vitro FW cord-334454-cqaado3u 165 1 Alpha alpha NN cord-334454-cqaado3u 165 2 interferon interferon NN cord-334454-cqaado3u 165 3 ( ( -LRB- cord-334454-cqaado3u 165 4 2b 2b LS cord-334454-cqaado3u 165 5 ) ) -RRB- cord-334454-cqaado3u 165 6 in in IN cord-334454-cqaado3u 165 7 combination combination NN cord-334454-cqaado3u 165 8 with with IN cord-334454-cqaado3u 165 9 zidovudine zidovudine NN cord-334454-cqaado3u 165 10 for for IN cord-334454-cqaado3u 165 11 the the DT cord-334454-cqaado3u 165 12 treatment treatment NN cord-334454-cqaado3u 165 13 of of IN cord-334454-cqaado3u 165 14 presymptomatic presymptomatic JJ cord-334454-cqaado3u 165 15 feline feline JJ cord-334454-cqaado3u 165 16 leukemia leukemia NN cord-334454-cqaado3u 165 17 virus virus NN cord-334454-cqaado3u 165 18 - - HYPH cord-334454-cqaado3u 165 19 induced induce VBN cord-334454-cqaado3u 165 20 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 165 21 syndrome syndrome NN cord-334454-cqaado3u 165 22 Antiviral antiviral JJ cord-334454-cqaado3u 165 23 potency potency NN cord-334454-cqaado3u 165 24 of of IN cord-334454-cqaado3u 165 25 interferon interferon NN cord-334454-cqaado3u 165 26 omega omega NN cord-334454-cqaado3u 165 27 against against IN cord-334454-cqaado3u 165 28 selected select VBN cord-334454-cqaado3u 165 29 canine canine JJ cord-334454-cqaado3u 165 30 and and CC cord-334454-cqaado3u 165 31 feline feline JJ cord-334454-cqaado3u 165 32 viruses virus NNS cord-334454-cqaado3u 165 33 Oral oral JJ cord-334454-cqaado3u 165 34 Recombinant recombinant JJ cord-334454-cqaado3u 165 35 Feline Feline NNP cord-334454-cqaado3u 165 36 Interferon Interferon NNP cord-334454-cqaado3u 165 37 - - HYPH cord-334454-cqaado3u 165 38 Omega Omega NNP cord-334454-cqaado3u 165 39 as as IN cord-334454-cqaado3u 165 40 an an DT cord-334454-cqaado3u 165 41 alternative alternative JJ cord-334454-cqaado3u 165 42 immune immune JJ cord-334454-cqaado3u 165 43 modulation modulation NN cord-334454-cqaado3u 165 44 therapy therapy NN cord-334454-cqaado3u 165 45 in in IN cord-334454-cqaado3u 165 46 FIV FIV NNP cord-334454-cqaado3u 165 47 positive positive JJ cord-334454-cqaado3u 165 48 cats cat NNS cord-334454-cqaado3u 165 49 : : : cord-334454-cqaado3u 166 1 Clinical clinical JJ cord-334454-cqaado3u 166 2 and and CC cord-334454-cqaado3u 166 3 laboratory laboratory NN cord-334454-cqaado3u 166 4 evaluation evaluation NN cord-334454-cqaado3u 166 5 Relevance relevance NN cord-334454-cqaado3u 166 6 of of IN cord-334454-cqaado3u 166 7 feline feline JJ cord-334454-cqaado3u 166 8 interferon interferon NN cord-334454-cqaado3u 166 9 omega omega NN cord-334454-cqaado3u 166 10 for for IN cord-334454-cqaado3u 166 11 clinical clinical JJ cord-334454-cqaado3u 166 12 improvement improvement NN cord-334454-cqaado3u 166 13 and and CC cord-334454-cqaado3u 166 14 reduction reduction NN cord-334454-cqaado3u 166 15 of of IN cord-334454-cqaado3u 166 16 concurrent concurrent JJ cord-334454-cqaado3u 166 17 viral viral JJ cord-334454-cqaado3u 166 18 excretion excretion NN cord-334454-cqaado3u 166 19 in in IN cord-334454-cqaado3u 166 20 retrovirus retrovirus NN cord-334454-cqaado3u 166 21 infected infect VBN cord-334454-cqaado3u 166 22 cats cat NNS cord-334454-cqaado3u 166 23 from from IN cord-334454-cqaado3u 166 24 a a DT cord-334454-cqaado3u 166 25 rescue rescue NN cord-334454-cqaado3u 166 26 shelter shelter NN cord-334454-cqaado3u 166 27 Evaluation Evaluation NNP cord-334454-cqaado3u 166 28 of of IN cord-334454-cqaado3u 166 29 viremia viremia NNP cord-334454-cqaado3u 166 30 , , , cord-334454-cqaado3u 166 31 proviral proviral NNP cord-334454-cqaado3u 166 32 load load NN cord-334454-cqaado3u 166 33 and and CC cord-334454-cqaado3u 166 34 cytokine cytokine NN cord-334454-cqaado3u 166 35 profile profile NN cord-334454-cqaado3u 166 36 in in IN cord-334454-cqaado3u 166 37 naturally naturally RB cord-334454-cqaado3u 166 38 feline feline JJ cord-334454-cqaado3u 166 39 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 166 40 virus virus NN cord-334454-cqaado3u 166 41 infected infect VBN cord-334454-cqaado3u 166 42 cats cat NNS cord-334454-cqaado3u 166 43 treated treat VBN cord-334454-cqaado3u 166 44 with with IN cord-334454-cqaado3u 166 45 two two CD cord-334454-cqaado3u 166 46 different different JJ cord-334454-cqaado3u 166 47 protocols protocol NNS cord-334454-cqaado3u 166 48 of of IN cord-334454-cqaado3u 166 49 recombinant recombinant JJ cord-334454-cqaado3u 166 50 feline feline JJ cord-334454-cqaado3u 166 51 interferon interferon NN cord-334454-cqaado3u 166 52 omega omega NNP cord-334454-cqaado3u 166 53 Monitoring Monitoring NNP cord-334454-cqaado3u 166 54 acute acute JJ cord-334454-cqaado3u 166 55 phase phase NN cord-334454-cqaado3u 166 56 proteins protein NNS cord-334454-cqaado3u 166 57 in in IN cord-334454-cqaado3u 166 58 retrovirus retrovirus NN cord-334454-cqaado3u 166 59 infected infect VBN cord-334454-cqaado3u 166 60 cats cat NNS cord-334454-cqaado3u 166 61 undergoing undergo VBG cord-334454-cqaado3u 166 62 feline feline JJ cord-334454-cqaado3u 166 63 interferon interferon NN cord-334454-cqaado3u 166 64 - - HYPH cord-334454-cqaado3u 166 65 ω ω VBG cord-334454-cqaado3u 166 66 therapy therapy NN cord-334454-cqaado3u 167 1 The the DT cord-334454-cqaado3u 167 2 acute acute JJ cord-334454-cqaado3u 167 3 - - HYPH cord-334454-cqaado3u 167 4 phase phase NN cord-334454-cqaado3u 167 5 protein protein NN cord-334454-cqaado3u 167 6 response response NN cord-334454-cqaado3u 167 7 to to IN cord-334454-cqaado3u 167 8 human human JJ cord-334454-cqaado3u 167 9 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 167 10 virus virus NN cord-334454-cqaado3u 167 11 infection infection NN cord-334454-cqaado3u 167 12 in in IN cord-334454-cqaado3u 167 13 human human JJ cord-334454-cqaado3u 167 14 subjects subject NNS cord-334454-cqaado3u 168 1 Lipid lipid NN cord-334454-cqaado3u 168 2 and and CC cord-334454-cqaado3u 168 3 acute acute JJ cord-334454-cqaado3u 168 4 - - HYPH cord-334454-cqaado3u 168 5 phase phase NN cord-334454-cqaado3u 168 6 protein protein NN cord-334454-cqaado3u 168 7 alterations alteration NNS cord-334454-cqaado3u 168 8 in in IN cord-334454-cqaado3u 168 9 HIV-1 HIV-1 NNP cord-334454-cqaado3u 168 10 infected infect VBD cord-334454-cqaado3u 168 11 patients patient NNS cord-334454-cqaado3u 168 12 in in IN cord-334454-cqaado3u 168 13 the the DT cord-334454-cqaado3u 168 14 early early JJ cord-334454-cqaado3u 168 15 stages stage NNS cord-334454-cqaado3u 168 16 of of IN cord-334454-cqaado3u 168 17 infection infection NN cord-334454-cqaado3u 168 18 : : : cord-334454-cqaado3u 169 1 Correlation correlation NN cord-334454-cqaado3u 169 2 with with IN cord-334454-cqaado3u 169 3 CD4 CD4 NNP cord-334454-cqaado3u 169 4 + + CC cord-334454-cqaado3u 169 5 lymphocytes lymphocyte NNS cord-334454-cqaado3u 169 6 . . . cord-334454-cqaado3u 170 1 Braz Braz NNP cord-334454-cqaado3u 170 2 Changes change NNS cord-334454-cqaado3u 170 3 in in IN cord-334454-cqaado3u 170 4 the the DT cord-334454-cqaado3u 170 5 levels level NNS cord-334454-cqaado3u 170 6 of of IN cord-334454-cqaado3u 170 7 some some DT cord-334454-cqaado3u 170 8 acute acute JJ cord-334454-cqaado3u 170 9 - - HYPH cord-334454-cqaado3u 170 10 phase phase NN cord-334454-cqaado3u 170 11 proteins protein NNS cord-334454-cqaado3u 170 12 in in IN cord-334454-cqaado3u 170 13 human human JJ cord-334454-cqaado3u 170 14 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 170 15 virus-1 virus-1 NN cord-334454-cqaado3u 170 16 infected infect VBN cord-334454-cqaado3u 170 17 patients patient NNS cord-334454-cqaado3u 170 18 , , , cord-334454-cqaado3u 170 19 following follow VBG cord-334454-cqaado3u 170 20 interleukin-2 interleukin-2 IN cord-334454-cqaado3u 170 21 treatment treatment NN cord-334454-cqaado3u 170 22 Feline feline JJ cord-334454-cqaado3u 170 23 immunodeficiency immunodeficiency NN cord-334454-cqaado3u 170 24 . . . cord-334454-cqaado3u 171 1 ABCD ABCD NNP cord-334454-cqaado3u 171 2 guidelines guideline NNS cord-334454-cqaado3u 171 3 on on IN cord-334454-cqaado3u 171 4 prevention prevention NN cord-334454-cqaado3u 171 5 and and CC cord-334454-cqaado3u 171 6 management management NN cord-334454-cqaado3u 171 7 Acute acute NN cord-334454-cqaado3u 171 8 phase phase NN cord-334454-cqaado3u 171 9 proteins protein NNS cord-334454-cqaado3u 171 10 in in IN cord-334454-cqaado3u 171 11 dogs dog NNS cord-334454-cqaado3u 171 12 and and CC cord-334454-cqaado3u 171 13 cats cat NNS cord-334454-cqaado3u 171 14 : : : cord-334454-cqaado3u 172 1 Current current JJ cord-334454-cqaado3u 172 2 knowledge knowledge NN cord-334454-cqaado3u 172 3 and and CC cord-334454-cqaado3u 172 4 future future JJ cord-334454-cqaado3u 172 5 perspectives perspective NNS cord-334454-cqaado3u 173 1 The the DT cord-334454-cqaado3u 173 2 feline feline JJ cord-334454-cqaado3u 173 3 acute acute JJ cord-334454-cqaado3u 173 4 phase phase NN cord-334454-cqaado3u 173 5 reaction reaction NN cord-334454-cqaado3u 174 1 The the DT cord-334454-cqaado3u 174 2 innate innate JJ cord-334454-cqaado3u 174 3 antiviral antiviral JJ cord-334454-cqaado3u 174 4 immune immune JJ cord-334454-cqaado3u 174 5 system system NN cord-334454-cqaado3u 174 6 of of IN cord-334454-cqaado3u 174 7 the the DT cord-334454-cqaado3u 174 8 cat cat NN cord-334454-cqaado3u 174 9 : : : cord-334454-cqaado3u 175 1 Molecular molecular JJ cord-334454-cqaado3u 175 2 tools tool NNS cord-334454-cqaado3u 175 3 for for IN cord-334454-cqaado3u 175 4 the the DT cord-334454-cqaado3u 175 5 measurement measurement NN cord-334454-cqaado3u 175 6 of of IN cord-334454-cqaado3u 175 7 its -PRON- PRP$ cord-334454-cqaado3u 175 8 state state NN cord-334454-cqaado3u 175 9 of of IN cord-334454-cqaado3u 175 10 activation activation NN cord-334454-cqaado3u 175 11 Comparative comparative JJ cord-334454-cqaado3u 175 12 efficacy efficacy NN cord-334454-cqaado3u 175 13 of of IN cord-334454-cqaado3u 175 14 a a DT cord-334454-cqaado3u 175 15 recombinant recombinant JJ cord-334454-cqaado3u 175 16 feline feline JJ cord-334454-cqaado3u 175 17 interferon interferon NN cord-334454-cqaado3u 175 18 omega omega NN cord-334454-cqaado3u 175 19 in in IN cord-334454-cqaado3u 175 20 refractory refractory JJ cord-334454-cqaado3u 175 21 cases case NNS cord-334454-cqaado3u 175 22 of of IN cord-334454-cqaado3u 175 23 calicivirus calicivirus JJ cord-334454-cqaado3u 175 24 - - HYPH cord-334454-cqaado3u 175 25 positive positive JJ cord-334454-cqaado3u 175 26 cats cat NNS cord-334454-cqaado3u 175 27 with with IN cord-334454-cqaado3u 175 28 caudal caudal JJ cord-334454-cqaado3u 175 29 stomatitis stomatitis NN cord-334454-cqaado3u 175 30 : : : cord-334454-cqaado3u 175 31 A a DT cord-334454-cqaado3u 175 32 randomised randomised JJ cord-334454-cqaado3u 175 33 , , , cord-334454-cqaado3u 175 34 multi multi JJ cord-334454-cqaado3u 175 35 - - JJ cord-334454-cqaado3u 175 36 centre centre JJ cord-334454-cqaado3u 175 37 , , , cord-334454-cqaado3u 175 38 controlled control VBN cord-334454-cqaado3u 175 39 , , , cord-334454-cqaado3u 175 40 double double JJ cord-334454-cqaado3u 175 41 - - HYPH cord-334454-cqaado3u 175 42 blind blind JJ cord-334454-cqaado3u 175 43 study study NN cord-334454-cqaado3u 175 44 in in IN cord-334454-cqaado3u 175 45 39 39 CD cord-334454-cqaado3u 175 46 cats cat NNS cord-334454-cqaado3u 176 1 The the DT cord-334454-cqaado3u 176 2 research research NN cord-334454-cqaado3u 176 3 work work NN cord-334454-cqaado3u 176 4 that that WDT cord-334454-cqaado3u 176 5 conducted conduct VBD cord-334454-cqaado3u 176 6 to to IN cord-334454-cqaado3u 176 7 the the DT cord-334454-cqaado3u 176 8 mentioned mention VBN cord-334454-cqaado3u 176 9 conclusions conclusion NNS cord-334454-cqaado3u 176 10 was be VBD cord-334454-cqaado3u 176 11 part part NN cord-334454-cqaado3u 176 12 of of IN cord-334454-cqaado3u 176 13 the the DT cord-334454-cqaado3u 176 14 PhD phd NN cord-334454-cqaado3u 176 15 project project NN cord-334454-cqaado3u 176 16 of of IN cord-334454-cqaado3u 176 17 Rodolfo Rodolfo NNP cord-334454-cqaado3u 176 18 Oliveira Oliveira NNP cord-334454-cqaado3u 176 19 Leal Leal NNP cord-334454-cqaado3u 176 20 . . . cord-334454-cqaado3u 177 1 This this DT cord-334454-cqaado3u 177 2 project project NN cord-334454-cqaado3u 177 3 was be VBD cord-334454-cqaado3u 177 4 kindly kindly RB cord-334454-cqaado3u 177 5 sponsored sponsor VBN cord-334454-cqaado3u 177 6 by by IN cord-334454-cqaado3u 177 7 FCT FCT NNP cord-334454-cqaado3u 177 8 ( ( -LRB- cord-334454-cqaado3u 177 9 Fundação Fundação NNP cord-334454-cqaado3u 177 10 para para NNP cord-334454-cqaado3u 178 1 a a DT cord-334454-cqaado3u 178 2 Ciência Ciência NNP cord-334454-cqaado3u 178 3 e e NN cord-334454-cqaado3u 178 4 Tecnologia Tecnologia NNP cord-334454-cqaado3u 178 5 - - HYPH cord-334454-cqaado3u 178 6 PhD PhD NNP cord-334454-cqaado3u 178 7 grant grant NN cord-334454-cqaado3u 178 8 BD/62917/2009 BD/62917/2009 NNP cord-334454-cqaado3u 178 9 ) ) -RRB- cord-334454-cqaado3u 178 10 and and CC cord-334454-cqaado3u 178 11 CIISA CIISA NNP cord-334454-cqaado3u 179 1 ( ( -LRB- cord-334454-cqaado3u 179 2 Centro Centro NNP cord-334454-cqaado3u 179 3 de de FW cord-334454-cqaado3u 179 4 Investigação Investigação NNP cord-334454-cqaado3u 179 5 Interdisciplinar Interdisciplinar NNP cord-334454-cqaado3u 179 6 em -PRON- NNP cord-334454-cqaado3u 179 7 Sanidade Sanidade NNP cord-334454-cqaado3u 179 8 Animal Animal NNP cord-334454-cqaado3u 179 9 ) ) -RRB- cord-334454-cqaado3u 179 10 of of IN cord-334454-cqaado3u 179 11 the the DT cord-334454-cqaado3u 179 12 FMV FMV NNP cord-334454-cqaado3u 179 13 - - HYPH cord-334454-cqaado3u 179 14 ULisboa ULisboa NNP cord-334454-cqaado3u 179 15 and and CC cord-334454-cqaado3u 179 16 Virbac Virbac NNP cord-334454-cqaado3u 179 17 company company NN cord-334454-cqaado3u 179 18 . . . cord-334454-cqaado3u 180 1 Author Author NNP cord-334454-cqaado3u 180 2 Contributions contribution NNS cord-334454-cqaado3u 180 3 : : : cord-334454-cqaado3u 180 4 This this DT cord-334454-cqaado3u 180 5 review review NN cord-334454-cqaado3u 180 6 was be VBD cord-334454-cqaado3u 180 7 entirely entirely RB cord-334454-cqaado3u 180 8 written write VBN cord-334454-cqaado3u 180 9 by by IN cord-334454-cqaado3u 180 10 Rodolfo Rodolfo NNP cord-334454-cqaado3u 180 11 Oliveira Oliveira NNP cord-334454-cqaado3u 180 12 Leal Leal NNP cord-334454-cqaado3u 180 13 and and CC cord-334454-cqaado3u 180 14 Solange Solange NNP cord-334454-cqaado3u 180 15 Gil Gil NNP cord-334454-cqaado3u 180 16 and and CC cord-334454-cqaado3u 180 17 was be VBD cord-334454-cqaado3u 180 18 based base VBN cord-334454-cqaado3u 180 19 on on IN cord-334454-cqaado3u 180 20 the the DT cord-334454-cqaado3u 180 21 recent recent JJ cord-334454-cqaado3u 180 22 conclusions conclusion NNS cord-334454-cqaado3u 180 23 of of IN cord-334454-cqaado3u 180 24 rFeIFNomega rfeifnomega JJ cord-334454-cqaado3u 180 25 studies study NNS cord-334454-cqaado3u 180 26 . . . cord-334454-cqaado3u 181 1 Both both DT cord-334454-cqaado3u 181 2 authors author NNS cord-334454-cqaado3u 181 3 contributed contribute VBD cord-334454-cqaado3u 181 4 equally equally RB cord-334454-cqaado3u 181 5 to to IN cord-334454-cqaado3u 181 6 the the DT cord-334454-cqaado3u 181 7 writing writing NN cord-334454-cqaado3u 181 8 of of IN cord-334454-cqaado3u 181 9 this this DT cord-334454-cqaado3u 181 10 review review NN cord-334454-cqaado3u 181 11 . . . cord-334454-cqaado3u 182 1 The the DT cord-334454-cqaado3u 182 2 authors author NNS cord-334454-cqaado3u 182 3 declare declare VBP cord-334454-cqaado3u 182 4 no no DT cord-334454-cqaado3u 182 5 conflict conflict NN cord-334454-cqaado3u 182 6 of of IN cord-334454-cqaado3u 182 7 interest interest NN cord-334454-cqaado3u 182 8 . . . cord-334454-cqaado3u 183 1 Virbac Virbac NNP cord-334454-cqaado3u 183 2 did do VBD cord-334454-cqaado3u 183 3 not not RB cord-334454-cqaado3u 183 4 interfere interfere VB cord-334454-cqaado3u 183 5 with with IN cord-334454-cqaado3u 183 6 the the DT cord-334454-cqaado3u 183 7 presented present VBN cord-334454-cqaado3u 183 8 conclusions conclusion NNS cord-334454-cqaado3u 183 9 . . . cord-334454-cqaado3u 184 1 The the DT cord-334454-cqaado3u 184 2 company company NN cord-334454-cqaado3u 184 3 only only RB cord-334454-cqaado3u 184 4 sponsored sponsor VBD cord-334454-cqaado3u 184 5 the the DT cord-334454-cqaado3u 184 6 above above RB cord-334454-cqaado3u 184 7 mentioned mention VBN cord-334454-cqaado3u 184 8 research research NN cord-334454-cqaado3u 184 9 work work NN cord-334454-cqaado3u 184 10 in in IN cord-334454-cqaado3u 184 11 a a DT cord-334454-cqaado3u 184 12 practical practical JJ cord-334454-cqaado3u 184 13 manner manner NN cord-334454-cqaado3u 184 14 by by IN cord-334454-cqaado3u 184 15 donating donate VBG cord-334454-cqaado3u 184 16 rFeIFN rfeifn NN cord-334454-cqaado3u 184 17 - - HYPH cord-334454-cqaado3u 184 18 ω ω JJ cord-334454-cqaado3u 184 19 ( ( -LRB- cord-334454-cqaado3u 184 20 Virbagen Virbagen NNP cord-334454-cqaado3u 184 21 ) ) -RRB- cord-334454-cqaado3u 184 22 which which WDT cord-334454-cqaado3u 184 23 was be VBD cord-334454-cqaado3u 184 24 administered administer VBN cord-334454-cqaado3u 184 25 to to IN cord-334454-cqaado3u 184 26 FIV FIV NNP cord-334454-cqaado3u 184 27 cats cat NNS cord-334454-cqaado3u 184 28 . . .