id sid tid token lemma pos cord-324690-82qsirnk 1 1 key key JJ cord-324690-82qsirnk 1 2 : : : cord-324690-82qsirnk 1 3 cord-324690 cord-324690 NNP cord-324690-82qsirnk 1 4 - - HYPH cord-324690-82qsirnk 1 5 82qsirnk 82qsirnk NN cord-324690-82qsirnk 1 6 authors author NNS cord-324690-82qsirnk 1 7 : : : cord-324690-82qsirnk 1 8 Dieffenbach Dieffenbach NNP cord-324690-82qsirnk 1 9 , , , cord-324690-82qsirnk 1 10 Carl Carl NNP cord-324690-82qsirnk 1 11 W W NNP cord-324690-82qsirnk 1 12 ; ; : cord-324690-82qsirnk 1 13 Fauci Fauci NNP cord-324690-82qsirnk 1 14 , , , cord-324690-82qsirnk 1 15 Anthony Anthony NNP cord-324690-82qsirnk 1 16 S S NNP cord-324690-82qsirnk 1 17 title title NN cord-324690-82qsirnk 1 18 : : : cord-324690-82qsirnk 2 1 The the DT cord-324690-82qsirnk 2 2 search search NN cord-324690-82qsirnk 2 3 for for IN cord-324690-82qsirnk 2 4 an an DT cord-324690-82qsirnk 2 5 HIV HIV NNP cord-324690-82qsirnk 2 6 vaccine vaccine NN cord-324690-82qsirnk 2 7 , , , cord-324690-82qsirnk 2 8 the the DT cord-324690-82qsirnk 2 9 journey journey NN cord-324690-82qsirnk 2 10 continues continue VBZ cord-324690-82qsirnk 2 11 date date NN cord-324690-82qsirnk 2 12 : : : cord-324690-82qsirnk 2 13 2020 2020 CD cord-324690-82qsirnk 2 14 - - HYPH cord-324690-82qsirnk 2 15 05 05 CD cord-324690-82qsirnk 2 16 - - HYPH cord-324690-82qsirnk 2 17 16 16 CD cord-324690-82qsirnk 2 18 journal journal NN cord-324690-82qsirnk 2 19 : : : cord-324690-82qsirnk 3 1 J J NNP cord-324690-82qsirnk 3 2 Int Int NNP cord-324690-82qsirnk 3 3 AIDS AIDS NNP cord-324690-82qsirnk 3 4 Soc Soc NNP cord-324690-82qsirnk 3 5 DOI doi NN cord-324690-82qsirnk 3 6 : : : cord-324690-82qsirnk 3 7 10.1002/ 10.1002/ CD cord-324690-82qsirnk 4 1 jia2.25506 jia2.25506 NNP cord-324690-82qsirnk 4 2 sha sha NNP cord-324690-82qsirnk 4 3 : : : cord-324690-82qsirnk 5 1 894a91c603e429e310d7218d6a52cdef54ec0676 894a91c603e429e310d7218d6a52cdef54ec0676 NNP cord-324690-82qsirnk 5 2 doc_id doc_id NNP cord-324690-82qsirnk 5 3 : : : cord-324690-82qsirnk 6 1 324690 324690 CD cord-324690-82qsirnk 6 2 cord_uid cord_uid NN cord-324690-82qsirnk 6 3 : : : cord-324690-82qsirnk 7 1 82qsirnk 82qsirnk NNP cord-324690-82qsirnk 7 2 nan nan NNP cord-324690-82qsirnk 8 1 As as IN cord-324690-82qsirnk 8 2 we -PRON- PRP cord-324690-82qsirnk 8 3 commemorate commemorate VBP cord-324690-82qsirnk 8 4 HIV HIV NNP cord-324690-82qsirnk 8 5 Vaccine Vaccine NNP cord-324690-82qsirnk 8 6 Awareness Awareness NNP cord-324690-82qsirnk 8 7 Day Day NNP cord-324690-82qsirnk 8 8 , , , cord-324690-82qsirnk 8 9 we -PRON- PRP cord-324690-82qsirnk 8 10 honour honour VBP cord-324690-82qsirnk 8 11 the the DT cord-324690-82qsirnk 8 12 thousands thousand NNS cord-324690-82qsirnk 8 13 of of IN cord-324690-82qsirnk 8 14 study study NN cord-324690-82qsirnk 8 15 participants participant NNS cord-324690-82qsirnk 8 16 and and CC cord-324690-82qsirnk 8 17 the the DT cord-324690-82qsirnk 8 18 research research NN cord-324690-82qsirnk 8 19 teams team NNS cord-324690-82qsirnk 8 20 that that WDT cord-324690-82qsirnk 8 21 have have VBP cord-324690-82qsirnk 8 22 played play VBN cord-324690-82qsirnk 8 23 essential essential JJ cord-324690-82qsirnk 8 24 roles role NNS cord-324690-82qsirnk 8 25 in in IN cord-324690-82qsirnk 8 26 the the DT cord-324690-82qsirnk 8 27 completed complete VBN cord-324690-82qsirnk 8 28 and and CC cord-324690-82qsirnk 8 29 ongoing ongoing JJ cord-324690-82qsirnk 8 30 vaccine vaccine NN cord-324690-82qsirnk 8 31 clinical clinical JJ cord-324690-82qsirnk 8 32 trials trial NNS cord-324690-82qsirnk 8 33 . . . cord-324690-82qsirnk 9 1 We -PRON- PRP cord-324690-82qsirnk 9 2 also also RB cord-324690-82qsirnk 9 3 recognize recognize VBP cord-324690-82qsirnk 9 4 the the DT cord-324690-82qsirnk 9 5 scientists scientist NNS cord-324690-82qsirnk 9 6 who who WP cord-324690-82qsirnk 9 7 have have VBP cord-324690-82qsirnk 9 8 spent spend VBN cord-324690-82qsirnk 9 9 years year NNS cord-324690-82qsirnk 9 10 dedicated dedicate VBN cord-324690-82qsirnk 9 11 to to IN cord-324690-82qsirnk 9 12 creating create VBG cord-324690-82qsirnk 9 13 the the DT cord-324690-82qsirnk 9 14 tools tool NNS cord-324690-82qsirnk 9 15 and and CC cord-324690-82qsirnk 9 16 technologies technology NNS cord-324690-82qsirnk 9 17 to to TO cord-324690-82qsirnk 9 18 end end VB cord-324690-82qsirnk 9 19 the the DT cord-324690-82qsirnk 9 20 global global JJ cord-324690-82qsirnk 9 21 HIV HIV NNP cord-324690-82qsirnk 9 22 epidemic epidemic NN cord-324690-82qsirnk 9 23 . . . cord-324690-82qsirnk 10 1 On on IN cord-324690-82qsirnk 10 2 this this DT cord-324690-82qsirnk 10 3 Vaccine Vaccine NNP cord-324690-82qsirnk 10 4 Awareness Awareness NNP cord-324690-82qsirnk 10 5 Day Day NNP cord-324690-82qsirnk 10 6 , , , cord-324690-82qsirnk 10 7 we -PRON- PRP cord-324690-82qsirnk 10 8 must must MD cord-324690-82qsirnk 10 9 acknowledge acknowledge VB cord-324690-82qsirnk 10 10 that that IN cord-324690-82qsirnk 10 11 the the DT cord-324690-82qsirnk 10 12 HIV HIV NNP cord-324690-82qsirnk 10 13 vaccine vaccine NN cord-324690-82qsirnk 10 14 research research NN cord-324690-82qsirnk 10 15 field field NN cord-324690-82qsirnk 10 16 is be VBZ cord-324690-82qsirnk 10 17 quickly quickly RB cord-324690-82qsirnk 10 18 approaching approach VBG cord-324690-82qsirnk 10 19 a a DT cord-324690-82qsirnk 10 20 critical critical JJ cord-324690-82qsirnk 10 21 crossroads crossroad NNS cord-324690-82qsirnk 10 22 . . . cord-324690-82qsirnk 11 1 This this DT cord-324690-82qsirnk 11 2 past past JJ cord-324690-82qsirnk 11 3 decade decade NN cord-324690-82qsirnk 11 4 has have VBZ cord-324690-82qsirnk 11 5 been be VBN cord-324690-82qsirnk 11 6 spent spend VBN cord-324690-82qsirnk 11 7 launching launch VBG cord-324690-82qsirnk 11 8 improved improve VBN cord-324690-82qsirnk 11 9 vaccine vaccine NN cord-324690-82qsirnk 11 10 concepts concept NNS cord-324690-82qsirnk 11 11 and and CC cord-324690-82qsirnk 11 12 immune immune NN cord-324690-82qsirnk 11 13 - - HYPH cord-324690-82qsirnk 11 14 based base VBN cord-324690-82qsirnk 11 15 strategies strategy NNS cord-324690-82qsirnk 11 16 into into IN cord-324690-82qsirnk 11 17 trials trial NNS cord-324690-82qsirnk 11 18 . . . cord-324690-82qsirnk 12 1 Despite despite IN cord-324690-82qsirnk 12 2 these these DT cord-324690-82qsirnk 12 3 advances advance NNS cord-324690-82qsirnk 12 4 , , , cord-324690-82qsirnk 12 5 a a DT cord-324690-82qsirnk 12 6 safe safe JJ cord-324690-82qsirnk 12 7 and and CC cord-324690-82qsirnk 12 8 durably durably RB cord-324690-82qsirnk 12 9 effective effective JJ cord-324690-82qsirnk 12 10 HIV HIV NNP cord-324690-82qsirnk 12 11 vaccine vaccine NN cord-324690-82qsirnk 12 12 has have VBZ cord-324690-82qsirnk 12 13 eluded elude VBN cord-324690-82qsirnk 12 14 us -PRON- PRP cord-324690-82qsirnk 12 15 . . . cord-324690-82qsirnk 13 1 In in IN cord-324690-82qsirnk 13 2 this this DT cord-324690-82qsirnk 13 3 regard regard NN cord-324690-82qsirnk 13 4 , , , cord-324690-82qsirnk 13 5 we -PRON- PRP cord-324690-82qsirnk 13 6 must must MD cord-324690-82qsirnk 13 7 evaluate evaluate VB cord-324690-82qsirnk 13 8 the the DT cord-324690-82qsirnk 13 9 current current JJ cord-324690-82qsirnk 13 10 state state NN cord-324690-82qsirnk 13 11 of of IN cord-324690-82qsirnk 13 12 the the DT cord-324690-82qsirnk 13 13 field field NN cord-324690-82qsirnk 13 14 and and CC cord-324690-82qsirnk 13 15 make make VB cord-324690-82qsirnk 13 16 appropriate appropriate JJ cord-324690-82qsirnk 13 17 adjustments adjustment NNS cord-324690-82qsirnk 13 18 to to TO cord-324690-82qsirnk 13 19 help help VB cord-324690-82qsirnk 13 20 speed speed VB cord-324690-82qsirnk 13 21 us -PRON- PRP cord-324690-82qsirnk 13 22 to to IN cord-324690-82qsirnk 13 23 our -PRON- PRP$ cord-324690-82qsirnk 13 24 goal goal NN cord-324690-82qsirnk 13 25 . . . cord-324690-82qsirnk 14 1 While while IN cord-324690-82qsirnk 14 2 this this DT cord-324690-82qsirnk 14 3 quest quest NN cord-324690-82qsirnk 14 4 for for IN cord-324690-82qsirnk 14 5 a a DT cord-324690-82qsirnk 14 6 vaccine vaccine NN cord-324690-82qsirnk 14 7 at at IN cord-324690-82qsirnk 14 8 times time NNS cord-324690-82qsirnk 14 9 may may MD cord-324690-82qsirnk 14 10 feel feel VB cord-324690-82qsirnk 14 11 extremely extremely RB cord-324690-82qsirnk 14 12 difficult difficult JJ cord-324690-82qsirnk 14 13 , , , cord-324690-82qsirnk 14 14 as as IN cord-324690-82qsirnk 14 15 evidenced evidence VBN cord-324690-82qsirnk 14 16 by by IN cord-324690-82qsirnk 14 17 the the DT cord-324690-82qsirnk 14 18 recent recent JJ cord-324690-82qsirnk 14 19 disappointing disappointing JJ cord-324690-82qsirnk 14 20 results result NNS cord-324690-82qsirnk 14 21 of of IN cord-324690-82qsirnk 14 22 a a DT cord-324690-82qsirnk 14 23 phase phase NN cord-324690-82qsirnk 14 24 III iii CD cord-324690-82qsirnk 14 25 efficacy efficacy NN cord-324690-82qsirnk 14 26 trial trial NN cord-324690-82qsirnk 14 27 , , , cord-324690-82qsirnk 14 28 HVTN HVTN NNP cord-324690-82qsirnk 14 29 702 702 NNP cord-324690-82qsirnk 14 30 , , , cord-324690-82qsirnk 14 31 described describe VBN cord-324690-82qsirnk 14 32 below below RB cord-324690-82qsirnk 14 33 , , , cord-324690-82qsirnk 14 34 we -PRON- PRP cord-324690-82qsirnk 14 35 must must MD cord-324690-82qsirnk 14 36 steadfastly steadfastly RB cord-324690-82qsirnk 14 37 move move VB cord-324690-82qsirnk 14 38 forward forward RB cord-324690-82qsirnk 14 39 to to TO cord-324690-82qsirnk 14 40 address address VB cord-324690-82qsirnk 14 41 critical critical JJ cord-324690-82qsirnk 14 42 research research NN cord-324690-82qsirnk 14 43 gaps gap NNS cord-324690-82qsirnk 14 44 and and CC cord-324690-82qsirnk 14 45 unanswered unanswered JJ cord-324690-82qsirnk 14 46 questions question NNS cord-324690-82qsirnk 14 47 . . . cord-324690-82qsirnk 15 1 As as IN cord-324690-82qsirnk 15 2 we -PRON- PRP cord-324690-82qsirnk 15 3 reflect reflect VBP cord-324690-82qsirnk 15 4 upon upon IN cord-324690-82qsirnk 15 5 the the DT cord-324690-82qsirnk 15 6 status status NN cord-324690-82qsirnk 15 7 of of IN cord-324690-82qsirnk 15 8 HIV HIV NNP cord-324690-82qsirnk 15 9 vaccine vaccine NN cord-324690-82qsirnk 15 10 research research NN cord-324690-82qsirnk 15 11 , , , cord-324690-82qsirnk 15 12 we -PRON- PRP cord-324690-82qsirnk 15 13 would would MD cord-324690-82qsirnk 15 14 be be VB cord-324690-82qsirnk 15 15 remiss remiss JJ cord-324690-82qsirnk 15 16 if if IN cord-324690-82qsirnk 15 17 we -PRON- PRP cord-324690-82qsirnk 15 18 did do VBD cord-324690-82qsirnk 15 19 not not RB cord-324690-82qsirnk 15 20 mention mention VB cord-324690-82qsirnk 15 21 the the DT cord-324690-82qsirnk 15 22 current current JJ cord-324690-82qsirnk 15 23 global global JJ cord-324690-82qsirnk 15 24 pandemic pandemic NN cord-324690-82qsirnk 15 25 caused cause VBN cord-324690-82qsirnk 15 26 by by IN cord-324690-82qsirnk 15 27 SARS SARS NNP cord-324690-82qsirnk 15 28 - - HYPH cord-324690-82qsirnk 15 29 CoV-2 CoV-2 NNP cord-324690-82qsirnk 15 30 . . . cord-324690-82qsirnk 16 1 It -PRON- PRP cord-324690-82qsirnk 16 2 is be VBZ cord-324690-82qsirnk 16 3 important important JJ cord-324690-82qsirnk 16 4 to to TO cord-324690-82qsirnk 16 5 acknowledge acknowledge VB cord-324690-82qsirnk 16 6 the the DT cord-324690-82qsirnk 16 7 global global JJ cord-324690-82qsirnk 16 8 response response NN cord-324690-82qsirnk 16 9 to to IN cord-324690-82qsirnk 16 10 the the DT cord-324690-82qsirnk 16 11 COVID-19 covid-19 JJ cord-324690-82qsirnk 16 12 epidemic epidemic NN cord-324690-82qsirnk 16 13 and and CC cord-324690-82qsirnk 16 14 to to TO cord-324690-82qsirnk 16 15 cite cite VB cord-324690-82qsirnk 16 16 the the DT cord-324690-82qsirnk 16 17 range range NN cord-324690-82qsirnk 16 18 of of IN cord-324690-82qsirnk 16 19 vaccine vaccine NN cord-324690-82qsirnk 16 20 platforms platform NNS cord-324690-82qsirnk 16 21 being be VBG cord-324690-82qsirnk 16 22 used use VBN cord-324690-82qsirnk 16 23 for for IN cord-324690-82qsirnk 16 24 anti anti JJ cord-324690-82qsirnk 16 25 - - JJ cord-324690-82qsirnk 16 26 SARS SARS NNP cord-324690-82qsirnk 16 27 - - HYPH cord-324690-82qsirnk 16 28 CoV-2 CoV-2 NNP cord-324690-82qsirnk 16 29 candidate candidate NN cord-324690-82qsirnk 16 30 vaccines vaccine NNS cord-324690-82qsirnk 16 31 that that WDT cord-324690-82qsirnk 16 32 have have VBP cord-324690-82qsirnk 16 33 their -PRON- PRP$ cord-324690-82qsirnk 16 34 origin origin NN cord-324690-82qsirnk 16 35 in in IN cord-324690-82qsirnk 16 36 HIV HIV NNP cord-324690-82qsirnk 16 37 vaccinology vaccinology NN cord-324690-82qsirnk 16 38 . . . cord-324690-82qsirnk 17 1 The the DT cord-324690-82qsirnk 17 2 HIV HIV NNP cord-324690-82qsirnk 17 3 vaccine vaccine NN cord-324690-82qsirnk 17 4 field field NN cord-324690-82qsirnk 17 5 is be VBZ cord-324690-82qsirnk 17 6 clearly clearly RB cord-324690-82qsirnk 17 7 assisting assist VBG cord-324690-82qsirnk 17 8 in in IN cord-324690-82qsirnk 17 9 addressing address VBG cord-324690-82qsirnk 17 10 this this DT cord-324690-82qsirnk 17 11 newly newly RB cord-324690-82qsirnk 17 12 emergent emergent JJ cord-324690-82qsirnk 17 13 pandemic pandemic NN cord-324690-82qsirnk 17 14 and and CC cord-324690-82qsirnk 17 15 the the DT cord-324690-82qsirnk 17 16 National National NNP cord-324690-82qsirnk 17 17 Institute Institute NNP cord-324690-82qsirnk 17 18 of of IN cord-324690-82qsirnk 17 19 Allergy Allergy NNP cord-324690-82qsirnk 17 20 and and CC cord-324690-82qsirnk 17 21 Infectious Infectious NNP cord-324690-82qsirnk 17 22 Diseases Diseases NNPS cord-324690-82qsirnk 17 23 ( ( -LRB- cord-324690-82qsirnk 17 24 NIAID NIAID NNP cord-324690-82qsirnk 17 25 ) ) -RRB- cord-324690-82qsirnk 18 1 is be VBZ cord-324690-82qsirnk 18 2 fostering foster VBG cord-324690-82qsirnk 18 3 these these DT cord-324690-82qsirnk 18 4 essential essential JJ cord-324690-82qsirnk 18 5 collaborations collaboration NNS cord-324690-82qsirnk 18 6 . . . cord-324690-82qsirnk 19 1 For for IN cord-324690-82qsirnk 19 2 HIV HIV NNP cord-324690-82qsirnk 19 3 Vaccine Vaccine NNP cord-324690-82qsirnk 19 4 Awareness Awareness NNP cord-324690-82qsirnk 19 5 Day Day NNP cord-324690-82qsirnk 19 6 in in IN cord-324690-82qsirnk 19 7 2020 2020 CD cord-324690-82qsirnk 19 8 , , , cord-324690-82qsirnk 19 9 we -PRON- PRP cord-324690-82qsirnk 19 10 emphatically emphatically RB cord-324690-82qsirnk 19 11 state state VBP cord-324690-82qsirnk 19 12 that that IN cord-324690-82qsirnk 19 13 finding find VBG cord-324690-82qsirnk 19 14 safe safe JJ cord-324690-82qsirnk 19 15 , , , cord-324690-82qsirnk 19 16 effective effective JJ cord-324690-82qsirnk 19 17 and and CC cord-324690-82qsirnk 19 18 durable durable JJ cord-324690-82qsirnk 19 19 vaccines vaccine NNS cord-324690-82qsirnk 19 20 for for IN cord-324690-82qsirnk 19 21 HIV HIV NNP cord-324690-82qsirnk 19 22 and and CC cord-324690-82qsirnk 19 23 COVID-19 COVID-19 NNP cord-324690-82qsirnk 19 24 are be VBP cord-324690-82qsirnk 19 25 NIAID NIAID NNP cord-324690-82qsirnk 19 26 's 's POS cord-324690-82qsirnk 19 27 top top JJ cord-324690-82qsirnk 19 28 priorities priority NNS cord-324690-82qsirnk 19 29 . . . cord-324690-82qsirnk 20 1 The the DT cord-324690-82qsirnk 20 2 world world NN cord-324690-82qsirnk 20 3 must must MD cord-324690-82qsirnk 20 4 have have VB cord-324690-82qsirnk 20 5 both both DT cord-324690-82qsirnk 20 6 . . . cord-324690-82qsirnk 21 1 Based base VBN cord-324690-82qsirnk 21 2 upon upon IN cord-324690-82qsirnk 21 3 the the DT cord-324690-82qsirnk 21 4 challenges challenge NNS cord-324690-82qsirnk 21 5 that that WDT cord-324690-82qsirnk 21 6 HIV HIV NNP cord-324690-82qsirnk 21 7 biology biology NN cord-324690-82qsirnk 21 8 presents present VBZ cord-324690-82qsirnk 21 9 : : : cord-324690-82qsirnk 21 10 global global JJ cord-324690-82qsirnk 21 11 sequence sequence NN cord-324690-82qsirnk 21 12 diversity diversity NN cord-324690-82qsirnk 21 13 , , , cord-324690-82qsirnk 21 14 integration integration NN cord-324690-82qsirnk 21 15 of of IN cord-324690-82qsirnk 21 16 the the DT cord-324690-82qsirnk 21 17 viral viral JJ cord-324690-82qsirnk 21 18 genome genome NN cord-324690-82qsirnk 21 19 into into IN cord-324690-82qsirnk 21 20 the the DT cord-324690-82qsirnk 21 21 host host NN cord-324690-82qsirnk 21 22 cells cell NNS cord-324690-82qsirnk 21 23 and and CC cord-324690-82qsirnk 21 24 long long JJ cord-324690-82qsirnk 21 25 duration duration NN cord-324690-82qsirnk 21 26 of of IN cord-324690-82qsirnk 21 27 the the DT cord-324690-82qsirnk 21 28 symptom symptom NN cord-324690-82qsirnk 21 29 free free JJ cord-324690-82qsirnk 21 30 period period NN cord-324690-82qsirnk 21 31 of of IN cord-324690-82qsirnk 21 32 infection infection NN cord-324690-82qsirnk 21 33 as as RB cord-324690-82qsirnk 21 34 well well RB cord-324690-82qsirnk 21 35 as as IN cord-324690-82qsirnk 21 36 the the DT cord-324690-82qsirnk 21 37 fact fact NN cord-324690-82qsirnk 21 38 that that IN cord-324690-82qsirnk 21 39 no no DT cord-324690-82qsirnk 21 40 single single JJ cord-324690-82qsirnk 21 41 individual individual NN cord-324690-82qsirnk 21 42 has have VBZ cord-324690-82qsirnk 21 43 been be VBN cord-324690-82qsirnk 21 44 spontaneously spontaneously RB cord-324690-82qsirnk 21 45 cured cure VBN cord-324690-82qsirnk 21 46 , , , cord-324690-82qsirnk 21 47 it -PRON- PRP cord-324690-82qsirnk 21 48 is be VBZ cord-324690-82qsirnk 21 49 widely widely RB cord-324690-82qsirnk 21 50 accepted accept VBN cord-324690-82qsirnk 21 51 that that IN cord-324690-82qsirnk 21 52 a a DT cord-324690-82qsirnk 21 53 vaccine vaccine NN cord-324690-82qsirnk 21 54 must must MD cord-324690-82qsirnk 21 55 trigger trigger VB cord-324690-82qsirnk 21 56 responses response NNS cord-324690-82qsirnk 21 57 that that WDT cord-324690-82qsirnk 21 58 are be VBP cord-324690-82qsirnk 21 59 qualitatively qualitatively RB cord-324690-82qsirnk 21 60 different different JJ cord-324690-82qsirnk 21 61 from from IN cord-324690-82qsirnk 21 62 the the DT cord-324690-82qsirnk 21 63 immune immune JJ cord-324690-82qsirnk 21 64 responses response NNS cord-324690-82qsirnk 21 65 to to IN cord-324690-82qsirnk 21 66 natural natural JJ cord-324690-82qsirnk 21 67 infection infection NN cord-324690-82qsirnk 21 68 . . . cord-324690-82qsirnk 22 1 After after IN cord-324690-82qsirnk 22 2 the the DT cord-324690-82qsirnk 22 3 STEP step NN cord-324690-82qsirnk 22 4 trial trial NN cord-324690-82qsirnk 22 5 ( ( -LRB- cord-324690-82qsirnk 22 6 also also RB cord-324690-82qsirnk 22 7 referred refer VBN cord-324690-82qsirnk 22 8 to to IN cord-324690-82qsirnk 22 9 as as IN cord-324690-82qsirnk 22 10 HVTN HVTN NNP cord-324690-82qsirnk 22 11 502 502 CD cord-324690-82qsirnk 22 12 or or CC cord-324690-82qsirnk 22 13 Merck Merck NNP cord-324690-82qsirnk 22 14 V520 V520 NNP cord-324690-82qsirnk 22 15 - - HYPH cord-324690-82qsirnk 22 16 023 023 CD cord-324690-82qsirnk 22 17 ) ) -RRB- cord-324690-82qsirnk 22 18 was be VBD cord-324690-82qsirnk 22 19 halted halt VBN cord-324690-82qsirnk 22 20 in in IN cord-324690-82qsirnk 22 21 2007 2007 CD cord-324690-82qsirnk 22 22 , , , cord-324690-82qsirnk 22 23 vaccine vaccine NN cord-324690-82qsirnk 22 24 candidates candidate NNS cord-324690-82qsirnk 22 25 that that WDT cord-324690-82qsirnk 22 26 fulfilled fulfil VBD cord-324690-82qsirnk 22 27 these these DT cord-324690-82qsirnk 22 28 criteria criterion NNS cord-324690-82qsirnk 22 29 have have VBP cord-324690-82qsirnk 22 30 been be VBN cord-324690-82qsirnk 22 31 prioritized prioritize VBN cord-324690-82qsirnk 22 32 [ [ -LRB- cord-324690-82qsirnk 22 33 1 1 CD cord-324690-82qsirnk 22 34 , , , cord-324690-82qsirnk 22 35 2 2 CD cord-324690-82qsirnk 22 36 ] ] -RRB- cord-324690-82qsirnk 22 37 . . . cord-324690-82qsirnk 23 1 Over over IN cord-324690-82qsirnk 23 2 the the DT cord-324690-82qsirnk 23 3 past past JJ cord-324690-82qsirnk 23 4 decade decade NN cord-324690-82qsirnk 23 5 , , , cord-324690-82qsirnk 23 6 three three CD cord-324690-82qsirnk 23 7 different different JJ cord-324690-82qsirnk 23 8 vaccine vaccine NN cord-324690-82qsirnk 23 9 approaches approach NNS cord-324690-82qsirnk 23 10 have have VBP cord-324690-82qsirnk 23 11 been be VBN cord-324690-82qsirnk 23 12 implemented implement VBN cord-324690-82qsirnk 23 13 , , , cord-324690-82qsirnk 23 14 possible possible JJ cord-324690-82qsirnk 23 15 correlates correlate NNS cord-324690-82qsirnk 23 16 of of IN cord-324690-82qsirnk 23 17 protection protection NN cord-324690-82qsirnk 23 18 identified identify VBN cord-324690-82qsirnk 23 19 , , , cord-324690-82qsirnk 23 20 and and CC cord-324690-82qsirnk 23 21 two two CD cord-324690-82qsirnk 23 22 have have VBP cord-324690-82qsirnk 23 23 moved move VBN cord-324690-82qsirnk 23 24 through through IN cord-324690-82qsirnk 23 25 clinical clinical JJ cord-324690-82qsirnk 23 26 evaluation evaluation NN cord-324690-82qsirnk 23 27 to to IN cord-324690-82qsirnk 23 28 advanced advanced JJ cord-324690-82qsirnk 23 29 clinical clinical JJ cord-324690-82qsirnk 23 30 trials trial NNS cord-324690-82qsirnk 23 31 . . . cord-324690-82qsirnk 24 1 The the DT cord-324690-82qsirnk 24 2 first first JJ cord-324690-82qsirnk 24 3 of of IN cord-324690-82qsirnk 24 4 these these DT cord-324690-82qsirnk 24 5 was be VBD cord-324690-82qsirnk 24 6 based base VBN cord-324690-82qsirnk 24 7 upon upon IN cord-324690-82qsirnk 24 8 the the DT cord-324690-82qsirnk 24 9 correlates correlate NNS cord-324690-82qsirnk 24 10 of of IN cord-324690-82qsirnk 24 11 risk risk NN cord-324690-82qsirnk 24 12 that that WDT cord-324690-82qsirnk 24 13 were be VBD cord-324690-82qsirnk 24 14 generated generate VBN cord-324690-82qsirnk 24 15 from from IN cord-324690-82qsirnk 24 16 analysis analysis NN cord-324690-82qsirnk 24 17 of of IN cord-324690-82qsirnk 24 18 the the DT cord-324690-82qsirnk 24 19 RV144 RV144 NNP cord-324690-82qsirnk 24 20 trial trial NN cord-324690-82qsirnk 24 21 conducted conduct VBN cord-324690-82qsirnk 24 22 in in IN cord-324690-82qsirnk 24 23 Thailand Thailand NNP cord-324690-82qsirnk 24 24 , , , cord-324690-82qsirnk 24 25 which which WDT cord-324690-82qsirnk 24 26 in in IN cord-324690-82qsirnk 24 27 2009 2009 CD cord-324690-82qsirnk 24 28 , , , cord-324690-82qsirnk 24 29 reported report VBD cord-324690-82qsirnk 24 30 modest modest JJ cord-324690-82qsirnk 24 31 levels level NNS cord-324690-82qsirnk 24 32 of of IN cord-324690-82qsirnk 24 33 efficacy efficacy NN cord-324690-82qsirnk 24 34 [ [ -LRB- cord-324690-82qsirnk 24 35 3 3 CD cord-324690-82qsirnk 24 36 , , , cord-324690-82qsirnk 24 37 4 4 CD cord-324690-82qsirnk 24 38 ] ] -RRB- cord-324690-82qsirnk 24 39 . . . cord-324690-82qsirnk 25 1 Rather rather RB cord-324690-82qsirnk 25 2 than than IN cord-324690-82qsirnk 25 3 perform perform VB cord-324690-82qsirnk 25 4 a a DT cord-324690-82qsirnk 25 5 direct direct JJ cord-324690-82qsirnk 25 6 repeat repeat NN cord-324690-82qsirnk 25 7 of of IN cord-324690-82qsirnk 25 8 RV144 rv144 NN cord-324690-82qsirnk 25 9 in in IN cord-324690-82qsirnk 25 10 Thailand Thailand NNP cord-324690-82qsirnk 25 11 , , , cord-324690-82qsirnk 25 12 where where WRB cord-324690-82qsirnk 25 13 the the DT cord-324690-82qsirnk 25 14 epidemic epidemic NN cord-324690-82qsirnk 25 15 is be VBZ cord-324690-82qsirnk 25 16 driven drive VBN cord-324690-82qsirnk 25 17 by by IN cord-324690-82qsirnk 25 18 viruses virus NNS cord-324690-82qsirnk 25 19 from from IN cord-324690-82qsirnk 25 20 clades clade NNS cord-324690-82qsirnk 25 21 AE AE NNP cord-324690-82qsirnk 25 22 and and CC cord-324690-82qsirnk 25 23 B B NNP cord-324690-82qsirnk 25 24 , , , cord-324690-82qsirnk 25 25 a a DT cord-324690-82qsirnk 25 26 clade clade NN cord-324690-82qsirnk 25 27 C c NN cord-324690-82qsirnk 25 28 - - HYPH cord-324690-82qsirnk 25 29 specific specific JJ cord-324690-82qsirnk 25 30 regimen regimen NN cord-324690-82qsirnk 25 31 was be VBD cord-324690-82qsirnk 25 32 developed develop VBN cord-324690-82qsirnk 25 33 for for IN cord-324690-82qsirnk 25 34 testing testing NN cord-324690-82qsirnk 25 35 in in IN cord-324690-82qsirnk 25 36 Southern Southern NNP cord-324690-82qsirnk 25 37 Africa Africa NNP cord-324690-82qsirnk 25 38 . . . cord-324690-82qsirnk 26 1 When when WRB cord-324690-82qsirnk 26 2 evaluated evaluate VBN cord-324690-82qsirnk 26 3 in in IN cord-324690-82qsirnk 26 4 the the DT cord-324690-82qsirnk 26 5 HVTN100 HVTN100 NNP cord-324690-82qsirnk 26 6 trial trial NN cord-324690-82qsirnk 26 7 , , , cord-324690-82qsirnk 26 8 the the DT cord-324690-82qsirnk 26 9 relevant relevant JJ cord-324690-82qsirnk 26 10 correlate correlate VBP cord-324690-82qsirnk 26 11 responses response NNS cord-324690-82qsirnk 26 12 were be VBD cord-324690-82qsirnk 26 13 detected detect VBN cord-324690-82qsirnk 26 14 and and CC cord-324690-82qsirnk 26 15 shown show VBN cord-324690-82qsirnk 26 16 to to TO cord-324690-82qsirnk 26 17 be be VB cord-324690-82qsirnk 26 18 longer long RBR cord-324690-82qsirnk 26 19 lasting last VBG cord-324690-82qsirnk 26 20 than than IN cord-324690-82qsirnk 26 21 those those DT cord-324690-82qsirnk 26 22 of of IN cord-324690-82qsirnk 26 23 RV144 RV144 NNP cord-324690-82qsirnk 26 24 [ [ -LRB- cord-324690-82qsirnk 26 25 5 5 CD cord-324690-82qsirnk 26 26 ] ] -RRB- cord-324690-82qsirnk 26 27 [ [ -LRB- cord-324690-82qsirnk 26 28 6 6 CD cord-324690-82qsirnk 26 29 ] ] -RRB- cord-324690-82qsirnk 26 30 [ [ -LRB- cord-324690-82qsirnk 26 31 7 7 CD cord-324690-82qsirnk 26 32 ] ] -RRB- cord-324690-82qsirnk 26 33 . . . cord-324690-82qsirnk 27 1 With with IN cord-324690-82qsirnk 27 2 the the DT cord-324690-82qsirnk 27 3 go go VB cord-324690-82qsirnk 27 4 - - HYPH cord-324690-82qsirnk 27 5 no no DT cord-324690-82qsirnk 27 6 - - HYPH cord-324690-82qsirnk 27 7 go go JJ cord-324690-82qsirnk 27 8 criteria criterion NNS cord-324690-82qsirnk 27 9 for for IN cord-324690-82qsirnk 27 10 advancement advancement NN cord-324690-82qsirnk 27 11 met meet VBD cord-324690-82qsirnk 27 12 , , , cord-324690-82qsirnk 27 13 the the DT cord-324690-82qsirnk 27 14 HVTN702 HVTN702 NNP cord-324690-82qsirnk 27 15 study study NN cord-324690-82qsirnk 27 16 moved move VBD cord-324690-82qsirnk 27 17 ahead ahead RB cord-324690-82qsirnk 27 18 . . . cord-324690-82qsirnk 28 1 However however RB cord-324690-82qsirnk 28 2 , , , cord-324690-82qsirnk 28 3 no no DT cord-324690-82qsirnk 28 4 protection protection NN cord-324690-82qsirnk 28 5 was be VBD cord-324690-82qsirnk 28 6 observed observe VBN cord-324690-82qsirnk 28 7 , , , cord-324690-82qsirnk 28 8 and and CC cord-324690-82qsirnk 28 9 the the DT cord-324690-82qsirnk 28 10 trial trial NN cord-324690-82qsirnk 28 11 was be VBD cord-324690-82qsirnk 28 12 terminated terminate VBN cord-324690-82qsirnk 28 13 due due IN cord-324690-82qsirnk 28 14 to to IN cord-324690-82qsirnk 28 15 futility futility NN cord-324690-82qsirnk 28 16 . . . cord-324690-82qsirnk 29 1 While while IN cord-324690-82qsirnk 29 2 the the DT cord-324690-82qsirnk 29 3 field field NN cord-324690-82qsirnk 29 4 is be VBZ cord-324690-82qsirnk 29 5 disappointed disappoint VBN cord-324690-82qsirnk 29 6 with with IN cord-324690-82qsirnk 29 7 this this DT cord-324690-82qsirnk 29 8 outcome outcome NN cord-324690-82qsirnk 29 9 , , , cord-324690-82qsirnk 29 10 it -PRON- PRP cord-324690-82qsirnk 29 11 is be VBZ cord-324690-82qsirnk 29 12 important important JJ cord-324690-82qsirnk 29 13 to to TO cord-324690-82qsirnk 29 14 understand understand VB cord-324690-82qsirnk 29 15 the the DT cord-324690-82qsirnk 29 16 possible possible JJ cord-324690-82qsirnk 29 17 reasons reason NNS cord-324690-82qsirnk 29 18 for for IN cord-324690-82qsirnk 29 19 why why WRB cord-324690-82qsirnk 29 20 this this DT cord-324690-82qsirnk 29 21 occurred occur VBD cord-324690-82qsirnk 29 22 . . . cord-324690-82qsirnk 30 1 First first RB cord-324690-82qsirnk 30 2 , , , cord-324690-82qsirnk 30 3 there there EX cord-324690-82qsirnk 30 4 were be VBD cord-324690-82qsirnk 30 5 significant significant JJ cord-324690-82qsirnk 30 6 differences difference NNS cord-324690-82qsirnk 30 7 in in IN cord-324690-82qsirnk 30 8 the the DT cord-324690-82qsirnk 30 9 overall overall JJ cord-324690-82qsirnk 30 10 incidence incidence NN cord-324690-82qsirnk 30 11 between between IN cord-324690-82qsirnk 30 12 the the DT cord-324690-82qsirnk 30 13 study study NN cord-324690-82qsirnk 30 14 cohorts cohort NNS cord-324690-82qsirnk 30 15 in in IN cord-324690-82qsirnk 30 16 HVTN702 HVTN702 NNP cord-324690-82qsirnk 31 1 and and CC cord-324690-82qsirnk 31 2 RV144 rv144 LS cord-324690-82qsirnk 31 3 that that WDT cord-324690-82qsirnk 31 4 could could MD cord-324690-82qsirnk 31 5 have have VB cord-324690-82qsirnk 31 6 overwhelmed overwhelm VBN cord-324690-82qsirnk 31 7 a a DT cord-324690-82qsirnk 31 8 modestly modestly RB cord-324690-82qsirnk 31 9 protective protective JJ cord-324690-82qsirnk 31 10 response response NN cord-324690-82qsirnk 31 11 . . . cord-324690-82qsirnk 32 1 Additionally additionally RB cord-324690-82qsirnk 32 2 , , , cord-324690-82qsirnk 32 3 it -PRON- PRP cord-324690-82qsirnk 32 4 is be VBZ cord-324690-82qsirnk 32 5 conceivable conceivable JJ cord-324690-82qsirnk 32 6 that that IN cord-324690-82qsirnk 32 7 the the DT cord-324690-82qsirnk 32 8 correlates correlate NNS cord-324690-82qsirnk 32 9 observed observe VBN cord-324690-82qsirnk 32 10 in in IN cord-324690-82qsirnk 32 11 RV144 RV144 NNP cord-324690-82qsirnk 32 12 are be VBP cord-324690-82qsirnk 32 13 specific specific JJ cord-324690-82qsirnk 32 14 to to IN cord-324690-82qsirnk 32 15 the the DT cord-324690-82qsirnk 32 16 clades clade NNS cord-324690-82qsirnk 32 17 and and CC cord-324690-82qsirnk 32 18 population population NN cord-324690-82qsirnk 32 19 in in IN cord-324690-82qsirnk 32 20 Thailand Thailand NNP cord-324690-82qsirnk 32 21 and and CC cord-324690-82qsirnk 32 22 not not RB cord-324690-82qsirnk 32 23 transferable transferable JJ cord-324690-82qsirnk 32 24 to to IN cord-324690-82qsirnk 32 25 the the DT cord-324690-82qsirnk 32 26 Southern Southern NNP cord-324690-82qsirnk 32 27 Africa Africa NNP cord-324690-82qsirnk 32 28 epidemic epidemic NN cord-324690-82qsirnk 32 29 . . . cord-324690-82qsirnk 33 1 The the DT cord-324690-82qsirnk 33 2 remaining remain VBG cord-324690-82qsirnk 33 3 two two CD cord-324690-82qsirnk 33 4 vaccine vaccine NN cord-324690-82qsirnk 33 5 concepts concept NNS cord-324690-82qsirnk 33 6 have have VBP cord-324690-82qsirnk 33 7 reproducibly reproducibly RB cord-324690-82qsirnk 33 8 demonstrated demonstrate VBN cord-324690-82qsirnk 33 9 efficacy efficacy NN cord-324690-82qsirnk 33 10 in in IN cord-324690-82qsirnk 33 11 non non JJ cord-324690-82qsirnk 33 12 - - JJ cord-324690-82qsirnk 33 13 human human JJ cord-324690-82qsirnk 33 14 primate primate JJ cord-324690-82qsirnk 33 15 studies study NNS cord-324690-82qsirnk 33 16 . . . cord-324690-82qsirnk 34 1 The the DT cord-324690-82qsirnk 34 2 most most RBS cord-324690-82qsirnk 34 3 advanced advanced JJ cord-324690-82qsirnk 34 4 concept concept NN cord-324690-82qsirnk 34 5 is be VBZ cord-324690-82qsirnk 34 6 currently currently RB cord-324690-82qsirnk 34 7 being be VBG cord-324690-82qsirnk 34 8 evaluated evaluate VBN cord-324690-82qsirnk 34 9 in in IN cord-324690-82qsirnk 34 10 two two CD cord-324690-82qsirnk 34 11 studies study NNS cord-324690-82qsirnk 34 12 , , , cord-324690-82qsirnk 34 13 Imbokodo Imbokodo NNP cord-324690-82qsirnk 34 14 ( ( -LRB- cord-324690-82qsirnk 34 15 HVTN705 HVTN705 NNP cord-324690-82qsirnk 34 16 / / SYM cord-324690-82qsirnk 34 17 HPX2008 HPX2008 NNP cord-324690-82qsirnk 34 18 ) ) -RRB- cord-324690-82qsirnk 34 19 in in IN cord-324690-82qsirnk 34 20 women woman NNS cord-324690-82qsirnk 34 21 in in IN cord-324690-82qsirnk 34 22 Southern Southern NNP cord-324690-82qsirnk 34 23 Africa Africa NNP cord-324690-82qsirnk 34 24 and and CC cord-324690-82qsirnk 34 25 Mosaico Mosaico NNP cord-324690-82qsirnk 34 26 ( ( -LRB- cord-324690-82qsirnk 34 27 HVTN706 HVTN706 NNP cord-324690-82qsirnk 34 28 / / SYM cord-324690-82qsirnk 34 29 HPX3002 HPX3002 NNP cord-324690-82qsirnk 34 30 ) ) -RRB- cord-324690-82qsirnk 34 31 in in IN cord-324690-82qsirnk 34 32 men man NNS cord-324690-82qsirnk 34 33 and and CC cord-324690-82qsirnk 34 34 transgender transgender NN cord-324690-82qsirnk 34 35 persons person NNS cord-324690-82qsirnk 34 36 who who WP cord-324690-82qsirnk 34 37 have have VBP cord-324690-82qsirnk 34 38 sex sex NN cord-324690-82qsirnk 34 39 with with IN cord-324690-82qsirnk 34 40 men man NNS cord-324690-82qsirnk 34 41 in in IN cord-324690-82qsirnk 34 42 the the DT cord-324690-82qsirnk 34 43 Americas Americas NNPS cord-324690-82qsirnk 34 44 and and CC cord-324690-82qsirnk 34 45 Europe Europe NNP cord-324690-82qsirnk 34 46 [ [ -LRB- cord-324690-82qsirnk 34 47 8 8 CD cord-324690-82qsirnk 34 48 ] ] -RRB- cord-324690-82qsirnk 34 49 . . . cord-324690-82qsirnk 35 1 Analysis analysis NN cord-324690-82qsirnk 35 2 of of IN cord-324690-82qsirnk 35 3 the the DT cord-324690-82qsirnk 35 4 correlates correlate NNS cord-324690-82qsirnk 35 5 of of IN cord-324690-82qsirnk 35 6 protection protection NN cord-324690-82qsirnk 35 7 seen see VBN cord-324690-82qsirnk 35 8 in in IN cord-324690-82qsirnk 35 9 the the DT cord-324690-82qsirnk 35 10 non non JJ cord-324690-82qsirnk 35 11 - - JJ cord-324690-82qsirnk 35 12 human human JJ cord-324690-82qsirnk 35 13 primate primate JJ cord-324690-82qsirnk 35 14 studies study NNS cord-324690-82qsirnk 35 15 point point VBP cord-324690-82qsirnk 35 16 to to IN cord-324690-82qsirnk 35 17 qualitatively qualitatively RB cord-324690-82qsirnk 35 18 different different JJ cord-324690-82qsirnk 35 19 responses response NNS cord-324690-82qsirnk 35 20 than than IN cord-324690-82qsirnk 35 21 those those DT cord-324690-82qsirnk 35 22 observed observe VBN cord-324690-82qsirnk 35 23 in in IN cord-324690-82qsirnk 35 24 RV144 RV144 NNP cord-324690-82qsirnk 35 25 , , , cord-324690-82qsirnk 35 26 and and CC cord-324690-82qsirnk 35 27 the the DT cord-324690-82qsirnk 35 28 trials trial NNS cord-324690-82qsirnk 35 29 are be VBP cord-324690-82qsirnk 35 30 evaluating evaluate VBG cord-324690-82qsirnk 35 31 in in IN cord-324690-82qsirnk 35 32 silico silico NNS cord-324690-82qsirnk 35 33 designed design VBN cord-324690-82qsirnk 35 34 immunogens immunogen NNS cord-324690-82qsirnk 35 35 to to TO cord-324690-82qsirnk 35 36 present present VB cord-324690-82qsirnk 35 37 the the DT cord-324690-82qsirnk 35 38 most most RBS cord-324690-82qsirnk 35 39 globally globally RB cord-324690-82qsirnk 35 40 conserved conserve VBN cord-324690-82qsirnk 35 41 HIV HIV NNP cord-324690-82qsirnk 35 42 sequences sequence NNS cord-324690-82qsirnk 35 43 to to TO cord-324690-82qsirnk 35 44 trigger trigger VB cord-324690-82qsirnk 35 45 quantitatively quantitatively RB cord-324690-82qsirnk 35 46 superior superior JJ cord-324690-82qsirnk 35 47 CD8 CD8 NNP cord-324690-82qsirnk 35 48 + + CC cord-324690-82qsirnk 35 49 T T NNP cord-324690-82qsirnk 35 50 cell cell NN cord-324690-82qsirnk 35 51 responses response NNS cord-324690-82qsirnk 35 52 [ [ -LRB- cord-324690-82qsirnk 35 53 8 8 CD cord-324690-82qsirnk 35 54 , , , cord-324690-82qsirnk 35 55 9 9 CD cord-324690-82qsirnk 35 56 ] ] -RRB- cord-324690-82qsirnk 35 57 . . . cord-324690-82qsirnk 36 1 The the DT cord-324690-82qsirnk 36 2 third third JJ cord-324690-82qsirnk 36 3 approach approach NN cord-324690-82qsirnk 36 4 , , , cord-324690-82qsirnk 36 5 still still RB cord-324690-82qsirnk 36 6 in in IN cord-324690-82qsirnk 36 7 preclinical preclinical JJ cord-324690-82qsirnk 36 8 studies study NNS cord-324690-82qsirnk 36 9 , , , cord-324690-82qsirnk 36 10 is be VBZ cord-324690-82qsirnk 36 11 an an DT cord-324690-82qsirnk 36 12 SIV SIV NNP cord-324690-82qsirnk 36 13 vaccine vaccine NN cord-324690-82qsirnk 36 14 delivered deliver VBN cord-324690-82qsirnk 36 15 via via IN cord-324690-82qsirnk 36 16 the the DT cord-324690-82qsirnk 36 17 rhesus rhesu NNS cord-324690-82qsirnk 36 18 cytomegalovirus cytomegalovirus NNP cord-324690-82qsirnk 36 19 ( ( -LRB- cord-324690-82qsirnk 36 20 RhCMV RhCMV NNP cord-324690-82qsirnk 36 21 ) ) -RRB- cord-324690-82qsirnk 36 22 vector vector NN cord-324690-82qsirnk 36 23 platform platform NN cord-324690-82qsirnk 36 24 . . . cord-324690-82qsirnk 37 1 This this DT cord-324690-82qsirnk 37 2 strategy strategy NN cord-324690-82qsirnk 37 3 has have VBZ cord-324690-82qsirnk 37 4 been be VBN cord-324690-82qsirnk 37 5 shown show VBN cord-324690-82qsirnk 37 6 by by IN cord-324690-82qsirnk 37 7 Picker Picker NNP cord-324690-82qsirnk 37 8 and and CC cord-324690-82qsirnk 37 9 colleagues colleague NNS cord-324690-82qsirnk 37 10 to to TO cord-324690-82qsirnk 37 11 protect protect VB cord-324690-82qsirnk 37 12 50 50 CD cord-324690-82qsirnk 37 13 percent percent NN cord-324690-82qsirnk 37 14 of of IN cord-324690-82qsirnk 37 15 monkeys monkey NNS cord-324690-82qsirnk 37 16 from from IN cord-324690-82qsirnk 37 17 sustained sustained JJ cord-324690-82qsirnk 37 18 infection infection NN cord-324690-82qsirnk 37 19 [ [ -LRB- cord-324690-82qsirnk 37 20 10 10 CD cord-324690-82qsirnk 37 21 ] ] -RRB- cord-324690-82qsirnk 37 22 . . . cord-324690-82qsirnk 38 1 Efforts effort NNS cord-324690-82qsirnk 38 2 are be VBP cord-324690-82qsirnk 38 3 currently currently RB cord-324690-82qsirnk 38 4 underway underway JJ cord-324690-82qsirnk 38 5 to to TO cord-324690-82qsirnk 38 6 transition transition VB cord-324690-82qsirnk 38 7 to to IN cord-324690-82qsirnk 38 8 a a DT cord-324690-82qsirnk 38 9 human human JJ cord-324690-82qsirnk 38 10 CMV CMV NNP cord-324690-82qsirnk 38 11 vector vector NN cord-324690-82qsirnk 38 12 platform platform NN cord-324690-82qsirnk 38 13 with with IN cord-324690-82qsirnk 38 14 Phase phase NN cord-324690-82qsirnk 38 15 1 1 CD cord-324690-82qsirnk 38 16 clinical clinical JJ cord-324690-82qsirnk 38 17 trials trial NNS cord-324690-82qsirnk 38 18 expected expect VBN cord-324690-82qsirnk 38 19 in in IN cord-324690-82qsirnk 38 20 2021 2021 CD cord-324690-82qsirnk 38 21 . . . cord-324690-82qsirnk 39 1 Although although IN cord-324690-82qsirnk 39 2 humbled humble VBN cord-324690-82qsirnk 39 3 by by IN cord-324690-82qsirnk 39 4 the the DT cord-324690-82qsirnk 39 5 outcome outcome NN cord-324690-82qsirnk 39 6 of of IN cord-324690-82qsirnk 39 7 HVTN702 HVTN702 NNP cord-324690-82qsirnk 39 8 , , , cord-324690-82qsirnk 39 9 we -PRON- PRP cord-324690-82qsirnk 39 10 must must MD cord-324690-82qsirnk 39 11 continue continue VB cord-324690-82qsirnk 39 12 to to TO cord-324690-82qsirnk 39 13 explore explore VB cord-324690-82qsirnk 39 14 novel novel JJ cord-324690-82qsirnk 39 15 methods method NNS cord-324690-82qsirnk 39 16 of of IN cord-324690-82qsirnk 39 17 inducing induce VBG cord-324690-82qsirnk 39 18 or or CC cord-324690-82qsirnk 39 19 providing provide VBG cord-324690-82qsirnk 39 20 protective protective JJ cord-324690-82qsirnk 39 21 immunity immunity NN cord-324690-82qsirnk 39 22 against against IN cord-324690-82qsirnk 39 23 HIV HIV NNP cord-324690-82qsirnk 39 24 infection infection NN cord-324690-82qsirnk 39 25 . . . cord-324690-82qsirnk 40 1 One one CD cord-324690-82qsirnk 40 2 of of IN cord-324690-82qsirnk 40 3 the the DT cord-324690-82qsirnk 40 4 most most RBS cord-324690-82qsirnk 40 5 exciting exciting JJ cord-324690-82qsirnk 40 6 developments development NNS cord-324690-82qsirnk 40 7 in in IN cord-324690-82qsirnk 40 8 HIV HIV NNP cord-324690-82qsirnk 40 9 research research NN cord-324690-82qsirnk 40 10 has have VBZ cord-324690-82qsirnk 40 11 been be VBN cord-324690-82qsirnk 40 12 the the DT cord-324690-82qsirnk 40 13 ability ability NN cord-324690-82qsirnk 40 14 to to TO cord-324690-82qsirnk 40 15 isolate isolate VB cord-324690-82qsirnk 40 16 and and CC cord-324690-82qsirnk 40 17 produce produce VB cord-324690-82qsirnk 40 18 broadly broadly RB cord-324690-82qsirnk 40 19 neutralizing neutralize VBG cord-324690-82qsirnk 40 20 monoclonal monoclonal JJ cord-324690-82qsirnk 40 21 antibodies antibody NNS cord-324690-82qsirnk 40 22 ( ( -LRB- cord-324690-82qsirnk 40 23 bNAbs bnabs NN cord-324690-82qsirnk 40 24 ) ) -RRB- cord-324690-82qsirnk 40 25 that that WDT cord-324690-82qsirnk 40 26 neutralize neutralize VBP cord-324690-82qsirnk 40 27 nearly nearly RB cord-324690-82qsirnk 40 28 all all DT cord-324690-82qsirnk 40 29 of of IN cord-324690-82qsirnk 40 30 circulating circulate VBG cord-324690-82qsirnk 40 31 virus virus NN cord-324690-82qsirnk 40 32 strains strain NNS cord-324690-82qsirnk 40 33 from from IN cord-324690-82qsirnk 40 34 all all DT cord-324690-82qsirnk 40 35 clades clade NNS cord-324690-82qsirnk 40 36 [ [ -LRB- cord-324690-82qsirnk 40 37 11 11 CD cord-324690-82qsirnk 40 38 , , , cord-324690-82qsirnk 40 39 12 12 CD cord-324690-82qsirnk 40 40 ] ] -RRB- cord-324690-82qsirnk 40 41 . . . cord-324690-82qsirnk 41 1 These these DT cord-324690-82qsirnk 41 2 human human JJ cord-324690-82qsirnk 41 3 antibodies antibody NNS cord-324690-82qsirnk 41 4 prevent prevent VBP cord-324690-82qsirnk 41 5 acquisition acquisition NN cord-324690-82qsirnk 41 6 of of IN cord-324690-82qsirnk 41 7 SHIV SHIV NNP cord-324690-82qsirnk 41 8 infection infection NN cord-324690-82qsirnk 41 9 , , , cord-324690-82qsirnk 41 10 in in IN cord-324690-82qsirnk 41 11 a a DT cord-324690-82qsirnk 41 12 dose dose NN cord-324690-82qsirnk 41 13 dependent dependent JJ cord-324690-82qsirnk 41 14 manner manner NN cord-324690-82qsirnk 41 15 , , , cord-324690-82qsirnk 41 16 in in IN cord-324690-82qsirnk 41 17 animal animal NN cord-324690-82qsirnk 41 18 challenge challenge NN cord-324690-82qsirnk 41 19 models model NNS cord-324690-82qsirnk 41 20 and and CC cord-324690-82qsirnk 41 21 when when WRB cord-324690-82qsirnk 41 22 combinations combination NNS cord-324690-82qsirnk 41 23 of of IN cord-324690-82qsirnk 41 24 these these DT cord-324690-82qsirnk 41 25 antibodies antibody NNS cord-324690-82qsirnk 41 26 are be VBP cord-324690-82qsirnk 41 27 used use VBN cord-324690-82qsirnk 41 28 in in IN cord-324690-82qsirnk 41 29 people people NNS cord-324690-82qsirnk 41 30 living live VBG cord-324690-82qsirnk 41 31 with with IN cord-324690-82qsirnk 41 32 HIV HIV NNP cord-324690-82qsirnk 41 33 , , , cord-324690-82qsirnk 41 34 strong strong JJ cord-324690-82qsirnk 41 35 antiviral antiviral JJ cord-324690-82qsirnk 41 36 activity activity NN cord-324690-82qsirnk 41 37 has have VBZ cord-324690-82qsirnk 41 38 been be VBN cord-324690-82qsirnk 41 39 demonstrated demonstrate VBN cord-324690-82qsirnk 41 40 . . . cord-324690-82qsirnk 42 1 The the DT cord-324690-82qsirnk 42 2 Antibody Antibody NNP cord-324690-82qsirnk 42 3 Mediated Mediated NNP cord-324690-82qsirnk 42 4 Protection Protection NNP cord-324690-82qsirnk 42 5 ( ( -LRB- cord-324690-82qsirnk 42 6 AMP AMP NNP cord-324690-82qsirnk 42 7 ) ) -RRB- cord-324690-82qsirnk 42 8 trials trial NNS cord-324690-82qsirnk 42 9 are be VBP cord-324690-82qsirnk 42 10 currently currently RB cord-324690-82qsirnk 42 11 evaluating evaluate VBG cord-324690-82qsirnk 42 12 VRC01 VRC01 NNP cord-324690-82qsirnk 42 13 , , , cord-324690-82qsirnk 42 14 the the DT cord-324690-82qsirnk 42 15 CD4 CD4 NNP cord-324690-82qsirnk 42 16 binding bind VBG cord-324690-82qsirnk 42 17 site site NN cord-324690-82qsirnk 42 18 targeted target VBN cord-324690-82qsirnk 42 19 bNAb bNAb '' cord-324690-82qsirnk 42 20 , , , cord-324690-82qsirnk 42 21 to to TO cord-324690-82qsirnk 42 22 determine determine VB cord-324690-82qsirnk 42 23 the the DT cord-324690-82qsirnk 42 24 ability ability NN cord-324690-82qsirnk 42 25 of of IN cord-324690-82qsirnk 42 26 this this DT cord-324690-82qsirnk 42 27 single single JJ cord-324690-82qsirnk 42 28 antibody antibody NN cord-324690-82qsirnk 42 29 to to TO cord-324690-82qsirnk 42 30 prevent prevent VB cord-324690-82qsirnk 42 31 HIV HIV NNP cord-324690-82qsirnk 42 32 infection infection NN cord-324690-82qsirnk 42 33 in in IN cord-324690-82qsirnk 42 34 women woman NNS cord-324690-82qsirnk 42 35 in in IN cord-324690-82qsirnk 42 36 Southern Southern NNP cord-324690-82qsirnk 42 37 Africa Africa NNP cord-324690-82qsirnk 42 38 and and CC cord-324690-82qsirnk 42 39 MSM MSM NNP cord-324690-82qsirnk 42 40 and and CC cord-324690-82qsirnk 42 41 transgender transgender NN cord-324690-82qsirnk 42 42 persons person NNS cord-324690-82qsirnk 42 43 in in IN cord-324690-82qsirnk 42 44 the the DT cord-324690-82qsirnk 42 45 Americas Americas NNPS cord-324690-82qsirnk 42 46 [ [ -LRB- cord-324690-82qsirnk 42 47 13 13 CD cord-324690-82qsirnk 42 48 ] ] -RRB- cord-324690-82qsirnk 42 49 . . . cord-324690-82qsirnk 43 1 The the DT cord-324690-82qsirnk 43 2 AMP AMP NNP cord-324690-82qsirnk 43 3 studies study NNS cord-324690-82qsirnk 43 4 have have VBP cord-324690-82qsirnk 43 5 not not RB cord-324690-82qsirnk 43 6 been be VBN cord-324690-82qsirnk 43 7 impacted impact VBN cord-324690-82qsirnk 43 8 by by IN cord-324690-82qsirnk 43 9 COVID-19 COVID-19 NNP cord-324690-82qsirnk 43 10 , , , cord-324690-82qsirnk 43 11 and and CC cord-324690-82qsirnk 43 12 results result VBZ cord-324690-82qsirnk 43 13 from from IN cord-324690-82qsirnk 43 14 the the DT cord-324690-82qsirnk 43 15 AMP AMP NNP cord-324690-82qsirnk 43 16 studies study NNS cord-324690-82qsirnk 43 17 are be VBP cord-324690-82qsirnk 43 18 expected expect VBN cord-324690-82qsirnk 43 19 in in IN cord-324690-82qsirnk 43 20 fall fall NN cord-324690-82qsirnk 43 21 of of IN cord-324690-82qsirnk 43 22 2020 2020 CD cord-324690-82qsirnk 43 23 . . . cord-324690-82qsirnk 44 1 If if IN cord-324690-82qsirnk 44 2 protection protection NN cord-324690-82qsirnk 44 3 is be VBZ cord-324690-82qsirnk 44 4 observed observe VBN cord-324690-82qsirnk 44 5 in in IN cord-324690-82qsirnk 44 6 the the DT cord-324690-82qsirnk 44 7 AMP AMP NNP cord-324690-82qsirnk 44 8 trials trial NNS cord-324690-82qsirnk 44 9 , , , cord-324690-82qsirnk 44 10 an an DT cord-324690-82qsirnk 44 11 important important JJ cord-324690-82qsirnk 44 12 correlate correlate NN cord-324690-82qsirnk 44 13 for for IN cord-324690-82qsirnk 44 14 future future JJ cord-324690-82qsirnk 44 15 vaccine vaccine NN cord-324690-82qsirnk 44 16 studies study NNS cord-324690-82qsirnk 44 17 will will MD cord-324690-82qsirnk 44 18 be be VB cord-324690-82qsirnk 44 19 established establish VBN cord-324690-82qsirnk 44 20 . . . cord-324690-82qsirnk 45 1 In in IN cord-324690-82qsirnk 45 2 the the DT cord-324690-82qsirnk 45 3 meantime meantime NN cord-324690-82qsirnk 45 4 , , , cord-324690-82qsirnk 45 5 efforts effort NNS cord-324690-82qsirnk 45 6 are be VBP cord-324690-82qsirnk 45 7 underway underway JJ cord-324690-82qsirnk 45 8 to to TO cord-324690-82qsirnk 45 9 define define VB cord-324690-82qsirnk 45 10 immunogens immunogen NNS cord-324690-82qsirnk 45 11 that that IN cord-324690-82qsirnk 45 12 specifically specifically RB cord-324690-82qsirnk 45 13 trigger trigger VB cord-324690-82qsirnk 45 14 neutralizing neutralize VBG cord-324690-82qsirnk 45 15 antibodies antibody NNS cord-324690-82qsirnk 45 16 by by IN cord-324690-82qsirnk 45 17 targeting target VBG cord-324690-82qsirnk 45 18 five five CD cord-324690-82qsirnk 45 19 specific specific JJ cord-324690-82qsirnk 45 20 epitopes epitope NNS cord-324690-82qsirnk 45 21 , , , cord-324690-82qsirnk 45 22 which which WDT cord-324690-82qsirnk 45 23 are be VBP cord-324690-82qsirnk 45 24 unique unique JJ cord-324690-82qsirnk 45 25 sites site NNS cord-324690-82qsirnk 45 26 of of IN cord-324690-82qsirnk 45 27 vulnerability vulnerability NN cord-324690-82qsirnk 45 28 on on IN cord-324690-82qsirnk 45 29 the the DT cord-324690-82qsirnk 45 30 HIV HIV NNP cord-324690-82qsirnk 45 31 Env Env NNP cord-324690-82qsirnk 45 32 trimer trimer NN cord-324690-82qsirnk 45 33 glycoprotein glycoprotein NN cord-324690-82qsirnk 45 34 [ [ -LRB- cord-324690-82qsirnk 45 35 12 12 CD cord-324690-82qsirnk 45 36 , , , cord-324690-82qsirnk 45 37 14 14 CD cord-324690-82qsirnk 45 38 ] ] -RRB- cord-324690-82qsirnk 45 39 . . . cord-324690-82qsirnk 46 1 The the DT cord-324690-82qsirnk 46 2 goal goal NN cord-324690-82qsirnk 46 3 is be VBZ cord-324690-82qsirnk 46 4 to to TO cord-324690-82qsirnk 46 5 create create VB cord-324690-82qsirnk 46 6 a a DT cord-324690-82qsirnk 46 7 discrete discrete JJ cord-324690-82qsirnk 46 8 set set NN cord-324690-82qsirnk 46 9 of of IN cord-324690-82qsirnk 46 10 immunogens immunogen NNS cord-324690-82qsirnk 46 11 that that WDT cord-324690-82qsirnk 46 12 can can MD cord-324690-82qsirnk 46 13 reproducibly reproducibly RB cord-324690-82qsirnk 46 14 elicit elicit VB cord-324690-82qsirnk 46 15 the the DT cord-324690-82qsirnk 46 16 production production NN cord-324690-82qsirnk 46 17 of of IN cord-324690-82qsirnk 46 18 neutralizing neutralize VBG cord-324690-82qsirnk 46 19 antibody antibody NN cord-324690-82qsirnk 46 20 responses response NNS cord-324690-82qsirnk 46 21 against against IN cord-324690-82qsirnk 46 22 two two CD cord-324690-82qsirnk 46 23 or or CC cord-324690-82qsirnk 46 24 more more JJR cord-324690-82qsirnk 46 25 of of IN cord-324690-82qsirnk 46 26 these these DT cord-324690-82qsirnk 46 27 target target NN cord-324690-82qsirnk 46 28 sites site NNS cord-324690-82qsirnk 46 29 . . . cord-324690-82qsirnk 47 1 The the DT cord-324690-82qsirnk 47 2 Collaborative Collaborative NNP cord-324690-82qsirnk 47 3 HIV HIV NNP cord-324690-82qsirnk 47 4 Immunogen Immunogen NNP cord-324690-82qsirnk 47 5 Project Project NNP cord-324690-82qsirnk 47 6 [ [ -LRB- cord-324690-82qsirnk 47 7 12 12 CD cord-324690-82qsirnk 47 8 ] ] -RRB- cord-324690-82qsirnk 47 9 is be VBZ cord-324690-82qsirnk 47 10 seeking seek VBG cord-324690-82qsirnk 47 11 to to TO cord-324690-82qsirnk 47 12 prospectively prospectively RB cord-324690-82qsirnk 47 13 design design VB cord-324690-82qsirnk 47 14 and and CC cord-324690-82qsirnk 47 15 select select VB cord-324690-82qsirnk 47 16 the the DT cord-324690-82qsirnk 47 17 optimal optimal JJ cord-324690-82qsirnk 47 18 combination combination NN cord-324690-82qsirnk 47 19 of of IN cord-324690-82qsirnk 47 20 immunogens immunogen NNS cord-324690-82qsirnk 47 21 to to TO cord-324690-82qsirnk 47 22 be be VB cord-324690-82qsirnk 47 23 evaluated evaluate VBN cord-324690-82qsirnk 47 24 for for IN cord-324690-82qsirnk 47 25 the the DT cord-324690-82qsirnk 47 26 induction induction NN cord-324690-82qsirnk 47 27 of of IN cord-324690-82qsirnk 47 28 broad broad JJ cord-324690-82qsirnk 47 29 neutralization neutralization NN cord-324690-82qsirnk 47 30 of of IN cord-324690-82qsirnk 47 31 a a DT cord-324690-82qsirnk 47 32 range range NN cord-324690-82qsirnk 47 33 of of IN cord-324690-82qsirnk 47 34 HIV HIV NNP cord-324690-82qsirnk 47 35 isolates isolate VBZ cord-324690-82qsirnk 47 36 . . . cord-324690-82qsirnk 48 1 As as IN cord-324690-82qsirnk 48 2 we -PRON- PRP cord-324690-82qsirnk 48 3 reflect reflect VBP cord-324690-82qsirnk 48 4 on on IN cord-324690-82qsirnk 48 5 HIV HIV NNP cord-324690-82qsirnk 48 6 Vaccine Vaccine NNP cord-324690-82qsirnk 48 7 Awareness Awareness NNP cord-324690-82qsirnk 48 8 Day Day NNP cord-324690-82qsirnk 48 9 and and CC cord-324690-82qsirnk 48 10 recent recent JJ cord-324690-82qsirnk 48 11 developments development NNS cord-324690-82qsirnk 48 12 in in IN cord-324690-82qsirnk 48 13 the the DT cord-324690-82qsirnk 48 14 vaccine vaccine NN cord-324690-82qsirnk 48 15 field field NN cord-324690-82qsirnk 48 16 , , , cord-324690-82qsirnk 48 17 it -PRON- PRP cord-324690-82qsirnk 48 18 is be VBZ cord-324690-82qsirnk 48 19 clear clear JJ cord-324690-82qsirnk 48 20 that that IN cord-324690-82qsirnk 48 21 much much JJ cord-324690-82qsirnk 48 22 work work NN cord-324690-82qsirnk 48 23 remains remain VBZ cord-324690-82qsirnk 48 24 to to TO cord-324690-82qsirnk 48 25 be be VB cord-324690-82qsirnk 48 26 done do VBN cord-324690-82qsirnk 48 27 . . . cord-324690-82qsirnk 49 1 Going go VBG cord-324690-82qsirnk 49 2 forward forward RB cord-324690-82qsirnk 49 3 we -PRON- PRP cord-324690-82qsirnk 49 4 must must MD cord-324690-82qsirnk 49 5 continue continue VB cord-324690-82qsirnk 49 6 to to TO cord-324690-82qsirnk 49 7 engage engage VB cord-324690-82qsirnk 49 8 community community NN cord-324690-82qsirnk 49 9 to to TO cord-324690-82qsirnk 49 10 ensure ensure VB cord-324690-82qsirnk 49 11 a a DT cord-324690-82qsirnk 49 12 shared share VBN cord-324690-82qsirnk 49 13 understanding understanding NN cord-324690-82qsirnk 49 14 of of IN cord-324690-82qsirnk 49 15 our -PRON- PRP$ cord-324690-82qsirnk 49 16 common common JJ cord-324690-82qsirnk 49 17 goals goal NNS cord-324690-82qsirnk 49 18 . . . cord-324690-82qsirnk 50 1 While while IN cord-324690-82qsirnk 50 2 we -PRON- PRP cord-324690-82qsirnk 50 3 pursue pursue VBP cord-324690-82qsirnk 50 4 a a DT cord-324690-82qsirnk 50 5 safe safe JJ cord-324690-82qsirnk 50 6 and and CC cord-324690-82qsirnk 50 7 effective effective JJ cord-324690-82qsirnk 50 8 HIV HIV NNP cord-324690-82qsirnk 50 9 vaccine vaccine NN cord-324690-82qsirnk 50 10 , , , cord-324690-82qsirnk 50 11 we -PRON- PRP cord-324690-82qsirnk 50 12 are be VBP cord-324690-82qsirnk 50 13 also also RB cord-324690-82qsirnk 50 14 seeking seek VBG cord-324690-82qsirnk 50 15 ways way NNS cord-324690-82qsirnk 50 16 of of IN cord-324690-82qsirnk 50 17 improving improve VBG cord-324690-82qsirnk 50 18 chemoprophylaxis chemoprophylaxis NNP cord-324690-82qsirnk 50 19 . . . cord-324690-82qsirnk 51 1 We -PRON- PRP cord-324690-82qsirnk 51 2 remain remain VBP cord-324690-82qsirnk 51 3 optimistic optimistic JJ cord-324690-82qsirnk 51 4 that that IN cord-324690-82qsirnk 51 5 effective effective JJ cord-324690-82qsirnk 51 6 interventions intervention NNS cord-324690-82qsirnk 51 7 that that WDT cord-324690-82qsirnk 51 8 people people NNS cord-324690-82qsirnk 51 9 will will MD cord-324690-82qsirnk 51 10 reliably reliably RB cord-324690-82qsirnk 51 11 use use VB cord-324690-82qsirnk 51 12 can can MD cord-324690-82qsirnk 51 13 be be VB cord-324690-82qsirnk 51 14 developed develop VBN cord-324690-82qsirnk 51 15 and and CC cord-324690-82qsirnk 51 16 brought bring VBN cord-324690-82qsirnk 51 17 to to TO cord-324690-82qsirnk 51 18 scale scale VB cord-324690-82qsirnk 51 19 . . . cord-324690-82qsirnk 52 1 On on IN cord-324690-82qsirnk 52 2 HIV HIV NNP cord-324690-82qsirnk 52 3 Vaccine Vaccine NNP cord-324690-82qsirnk 52 4 Awareness Awareness NNP cord-324690-82qsirnk 52 5 Day Day NNP cord-324690-82qsirnk 52 6 , , , cord-324690-82qsirnk 52 7 let let VB cord-324690-82qsirnk 52 8 us -PRON- PRP cord-324690-82qsirnk 52 9 pause pause VB cord-324690-82qsirnk 52 10 and and CC cord-324690-82qsirnk 52 11 reflect reflect VB cord-324690-82qsirnk 52 12 on on IN cord-324690-82qsirnk 52 13 how how WRB cord-324690-82qsirnk 52 14 far far RB cord-324690-82qsirnk 52 15 we -PRON- PRP cord-324690-82qsirnk 52 16 have have VBP cord-324690-82qsirnk 52 17 come come VBN cord-324690-82qsirnk 52 18 while while IN cord-324690-82qsirnk 52 19 continuing continue VBG cord-324690-82qsirnk 52 20 to to TO cord-324690-82qsirnk 52 21 focus focus VB cord-324690-82qsirnk 52 22 on on IN cord-324690-82qsirnk 52 23 completing complete VBG cord-324690-82qsirnk 52 24 the the DT cord-324690-82qsirnk 52 25 work work NN cord-324690-82qsirnk 52 26 needed need VBN cord-324690-82qsirnk 52 27 to to TO cord-324690-82qsirnk 52 28 achieve achieve VB cord-324690-82qsirnk 52 29 an an DT cord-324690-82qsirnk 52 30 effective effective JJ cord-324690-82qsirnk 52 31 vaccine vaccine NN cord-324690-82qsirnk 52 32 . . . cord-324690-82qsirnk 53 1 The the DT cord-324690-82qsirnk 53 2 authors author NNS cord-324690-82qsirnk 53 3 collaboratively collaboratively RB cord-324690-82qsirnk 53 4 conceived conceive VBD cord-324690-82qsirnk 53 5 the the DT cord-324690-82qsirnk 53 6 content content NN cord-324690-82qsirnk 53 7 of of IN cord-324690-82qsirnk 53 8 the the DT cord-324690-82qsirnk 53 9 paper paper NN cord-324690-82qsirnk 53 10 . . . cord-324690-82qsirnk 54 1 CWD CWD NNP cord-324690-82qsirnk 54 2 wrote write VBD cord-324690-82qsirnk 54 3 the the DT cord-324690-82qsirnk 54 4 first first JJ cord-324690-82qsirnk 54 5 draft draft NN cord-324690-82qsirnk 54 6 and and CC cord-324690-82qsirnk 54 7 ASF ASF NNP cord-324690-82qsirnk 54 8 edited edit VBD cord-324690-82qsirnk 54 9 the the DT cord-324690-82qsirnk 54 10 manuscript manuscript NN cord-324690-82qsirnk 54 11 into into IN cord-324690-82qsirnk 54 12 this this DT cord-324690-82qsirnk 54 13 final final JJ cord-324690-82qsirnk 54 14 form form NN cord-324690-82qsirnk 54 15 . . . cord-324690-82qsirnk 55 1 The the DT cord-324690-82qsirnk 55 2 authors author NNS cord-324690-82qsirnk 55 3 thank thank VBP cord-324690-82qsirnk 55 4 the the DT cord-324690-82qsirnk 55 5 trial trial NN cord-324690-82qsirnk 55 6 participants participant NNS cord-324690-82qsirnk 55 7 , , , cord-324690-82qsirnk 55 8 community community NN cord-324690-82qsirnk 55 9 members member NNS cord-324690-82qsirnk 55 10 , , , cord-324690-82qsirnk 55 11 activists activist NNS cord-324690-82qsirnk 55 12 and and CC cord-324690-82qsirnk 55 13 researchers researcher NNS cord-324690-82qsirnk 55 14 who who WP cord-324690-82qsirnk 55 15 have have VBP cord-324690-82qsirnk 55 16 so so RB cord-324690-82qsirnk 55 17 willingly willingly RB cord-324690-82qsirnk 55 18 participated participate VBN cord-324690-82qsirnk 55 19 in in IN cord-324690-82qsirnk 55 20 the the DT cord-324690-82qsirnk 55 21 challenging challenging JJ cord-324690-82qsirnk 55 22 work work NN cord-324690-82qsirnk 55 23 of of IN cord-324690-82qsirnk 55 24 HIV HIV NNP cord-324690-82qsirnk 55 25 vaccine vaccine NN cord-324690-82qsirnk 55 26 discovery discovery NN cord-324690-82qsirnk 55 27 and and CC cord-324690-82qsirnk 55 28 development development NN cord-324690-82qsirnk 55 29 . . . cord-324690-82qsirnk 56 1 The the DT cord-324690-82qsirnk 56 2 authors author NNS cord-324690-82qsirnk 56 3 also also RB cord-324690-82qsirnk 56 4 thank thank VBP cord-324690-82qsirnk 56 5 Robert Robert NNP cord-324690-82qsirnk 56 6 Gulakowski Gulakowski NNP cord-324690-82qsirnk 56 7 , , , cord-324690-82qsirnk 56 8 Thomas Thomas NNP cord-324690-82qsirnk 56 9 Liang Liang NNP cord-324690-82qsirnk 56 10 , , , cord-324690-82qsirnk 56 11 Mary Mary NNP cord-324690-82qsirnk 56 12 Marovich Marovich NNP cord-324690-82qsirnk 56 13 and and CC cord-324690-82qsirnk 56 14 Sarah Sarah NNP cord-324690-82qsirnk 56 15 Read Read VBD cord-324690-82qsirnk 56 16 for for IN cord-324690-82qsirnk 56 17 their -PRON- PRP$ cord-324690-82qsirnk 56 18 careful careful JJ cord-324690-82qsirnk 56 19 review review NN cord-324690-82qsirnk 56 20 and and CC cord-324690-82qsirnk 56 21 comments comment NNS cord-324690-82qsirnk 56 22 on on IN cord-324690-82qsirnk 56 23 this this DT cord-324690-82qsirnk 56 24 manuscript manuscript NN cord-324690-82qsirnk 56 25 . . . cord-324690-82qsirnk 57 1 Overview Overview NNP cord-324690-82qsirnk 57 2 of of IN cord-324690-82qsirnk 57 3 STEP step NN cord-324690-82qsirnk 57 4 and and CC cord-324690-82qsirnk 57 5 Phambili Phambili NNP cord-324690-82qsirnk 57 6 trial trial NN cord-324690-82qsirnk 57 7 results result NNS cord-324690-82qsirnk 57 8 : : : cord-324690-82qsirnk 58 1 two two CD cord-324690-82qsirnk 58 2 phase phase NN cord-324690-82qsirnk 58 3 IIb iib JJ cord-324690-82qsirnk 58 4 test test NN cord-324690-82qsirnk 58 5 - - HYPH cord-324690-82qsirnk 58 6 of of IN cord-324690-82qsirnk 58 7 - - HYPH cord-324690-82qsirnk 58 8 concept concept NN cord-324690-82qsirnk 58 9 studies study NNS cord-324690-82qsirnk 58 10 investigating investigate VBG cord-324690-82qsirnk 58 11 the the DT cord-324690-82qsirnk 58 12 efficacy efficacy NN cord-324690-82qsirnk 58 13 of of IN cord-324690-82qsirnk 58 14 MRK MRK NNP cord-324690-82qsirnk 58 15 adenovirus adenovirus NN cord-324690-82qsirnk 58 16 type type NN cord-324690-82qsirnk 58 17 5 5 CD cord-324690-82qsirnk 58 18 gag gag NN cord-324690-82qsirnk 58 19 / / SYM cord-324690-82qsirnk 58 20 pol pol NN cord-324690-82qsirnk 58 21 / / SYM cord-324690-82qsirnk 58 22 nef nef NNP cord-324690-82qsirnk 58 23 subtype subtype NN cord-324690-82qsirnk 58 24 B B NNP cord-324690-82qsirnk 58 25 HIV HIV NNP cord-324690-82qsirnk 58 26 vaccine vaccine NN cord-324690-82qsirnk 58 27 HIV HIV NNP cord-324690-82qsirnk 58 28 vaccine vaccine NN cord-324690-82qsirnk 58 29 research research NN cord-324690-82qsirnk 58 30 : : : cord-324690-82qsirnk 58 31 the the DT cord-324690-82qsirnk 58 32 way way NN cord-324690-82qsirnk 58 33 forward forward RB cord-324690-82qsirnk 58 34 Vaccination vaccination NN cord-324690-82qsirnk 58 35 with with IN cord-324690-82qsirnk 58 36 ALVAC ALVAC NNP cord-324690-82qsirnk 58 37 and and CC cord-324690-82qsirnk 58 38 AIDSVAX AIDSVAX NNP cord-324690-82qsirnk 58 39 to to TO cord-324690-82qsirnk 58 40 prevent prevent VB cord-324690-82qsirnk 58 41 HIV-1 HIV-1 NNP cord-324690-82qsirnk 58 42 infection infection NN cord-324690-82qsirnk 58 43 in in IN cord-324690-82qsirnk 58 44 Thailand Thailand NNP cord-324690-82qsirnk 58 45 Immune Immune NNP cord-324690-82qsirnk 58 46 - - HYPH cord-324690-82qsirnk 58 47 correlates correlate VBZ cord-324690-82qsirnk 58 48 analysis analysis NN cord-324690-82qsirnk 58 49 of of IN cord-324690-82qsirnk 58 50 an an DT cord-324690-82qsirnk 58 51 HIV-1 HIV-1 NNP cord-324690-82qsirnk 58 52 vaccine vaccine NN cord-324690-82qsirnk 58 53 efficacy efficacy NN cord-324690-82qsirnk 58 54 trial trial NN cord-324690-82qsirnk 58 55 Subtype Subtype NNP cord-324690-82qsirnk 58 56 C C NNP cord-324690-82qsirnk 58 57 ALVAC ALVAC NNP cord-324690-82qsirnk 58 58 - - HYPH cord-324690-82qsirnk 58 59 HIV HIV NNP cord-324690-82qsirnk 58 60 and and CC cord-324690-82qsirnk 58 61 bivalent bivalent JJ cord-324690-82qsirnk 58 62 subtype subtype NN cord-324690-82qsirnk 58 63 C C NNP cord-324690-82qsirnk 58 64 gp120 gp120 NNP cord-324690-82qsirnk 58 65 / / SYM cord-324690-82qsirnk 58 66 MF59 MF59 NNP cord-324690-82qsirnk 58 67 HIV-1 HIV-1 NNP cord-324690-82qsirnk 58 68 vaccine vaccine NN cord-324690-82qsirnk 58 69 in in IN cord-324690-82qsirnk 58 70 low low JJ cord-324690-82qsirnk 58 71 - - HYPH cord-324690-82qsirnk 58 72 risk risk NN cord-324690-82qsirnk 58 73 , , , cord-324690-82qsirnk 58 74 HIV HIV NNP cord-324690-82qsirnk 58 75 - - HYPH cord-324690-82qsirnk 58 76 uninfected uninfected JJ cord-324690-82qsirnk 58 77 , , , cord-324690-82qsirnk 58 78 South south JJ cord-324690-82qsirnk 58 79 African african JJ cord-324690-82qsirnk 58 80 adults adult NNS cord-324690-82qsirnk 58 81 : : : cord-324690-82qsirnk 58 82 a a DT cord-324690-82qsirnk 58 83 phase phase NN cord-324690-82qsirnk 58 84 1/2 1/2 CD cord-324690-82qsirnk 58 85 trial trial NN cord-324690-82qsirnk 58 86 Safety safety NN cord-324690-82qsirnk 58 87 and and CC cord-324690-82qsirnk 58 88 immune immune JJ cord-324690-82qsirnk 58 89 responses response NNS cord-324690-82qsirnk 58 90 after after IN cord-324690-82qsirnk 58 91 a a DT cord-324690-82qsirnk 58 92 12-month 12-month JJ cord-324690-82qsirnk 58 93 booster booster NN cord-324690-82qsirnk 58 94 in in IN cord-324690-82qsirnk 58 95 healthy healthy JJ cord-324690-82qsirnk 58 96 HIV HIV NNP cord-324690-82qsirnk 58 97 - - HYPH cord-324690-82qsirnk 58 98 uninfected uninfected JJ cord-324690-82qsirnk 58 99 adults adult NNS cord-324690-82qsirnk 58 100 in in IN cord-324690-82qsirnk 58 101 HVTN HVTN NNP cord-324690-82qsirnk 58 102 100 100 CD cord-324690-82qsirnk 58 103 in in IN cord-324690-82qsirnk 58 104 South South NNP cord-324690-82qsirnk 58 105 Africa Africa NNP cord-324690-82qsirnk 58 106 : : : cord-324690-82qsirnk 59 1 A a DT cord-324690-82qsirnk 59 2 randomized randomized JJ cord-324690-82qsirnk 59 3 double double JJ cord-324690-82qsirnk 59 4 - - HYPH cord-324690-82qsirnk 59 5 blind blind JJ cord-324690-82qsirnk 59 6 placebocontrolled placebocontrolled JJ cord-324690-82qsirnk 59 7 trial trial NN cord-324690-82qsirnk 59 8 of of IN cord-324690-82qsirnk 59 9 ALVAC ALVAC NNP cord-324690-82qsirnk 59 10 - - HYPH cord-324690-82qsirnk 59 11 HIV HIV NNP cord-324690-82qsirnk 59 12 ( ( -LRB- cord-324690-82qsirnk 59 13 vCP2438 vcp2438 LS cord-324690-82qsirnk 59 14 ) ) -RRB- cord-324690-82qsirnk 59 15 and and CC cord-324690-82qsirnk 59 16 bivalent bivalent JJ cord-324690-82qsirnk 59 17 subtype subtype NN cord-324690-82qsirnk 60 1 C C NNP cord-324690-82qsirnk 60 2 gp120 gp120 NNP cord-324690-82qsirnk 60 3 / / SYM cord-324690-82qsirnk 60 4 MF59 MF59 NNP cord-324690-82qsirnk 60 5 vaccines vaccine NNS cord-324690-82qsirnk 61 1 Immune immune JJ cord-324690-82qsirnk 61 2 correlates correlate NNS cord-324690-82qsirnk 61 3 of of IN cord-324690-82qsirnk 61 4 the the DT cord-324690-82qsirnk 61 5 Thai Thai NNP cord-324690-82qsirnk 61 6 RV144 RV144 NNP cord-324690-82qsirnk 61 7 HIV HIV NNP cord-324690-82qsirnk 61 8 vaccine vaccine NN cord-324690-82qsirnk 61 9 regimen regimen NN cord-324690-82qsirnk 61 10 in in IN cord-324690-82qsirnk 61 11 South South NNP cord-324690-82qsirnk 61 12 Africa Africa NNP cord-324690-82qsirnk 61 13 Evaluation Evaluation NNP cord-324690-82qsirnk 61 14 of of IN cord-324690-82qsirnk 61 15 a a DT cord-324690-82qsirnk 61 16 mosaic mosaic JJ cord-324690-82qsirnk 61 17 HIV-1 HIV-1 NNP cord-324690-82qsirnk 61 18 vaccine vaccine NN cord-324690-82qsirnk 61 19 in in IN cord-324690-82qsirnk 61 20 a a DT cord-324690-82qsirnk 61 21 multicentre multicentre NNP cord-324690-82qsirnk 61 22 , , , cord-324690-82qsirnk 61 23 randomised randomised JJ cord-324690-82qsirnk 61 24 , , , cord-324690-82qsirnk 61 25 double double JJ cord-324690-82qsirnk 61 26 - - HYPH cord-324690-82qsirnk 61 27 blind blind JJ cord-324690-82qsirnk 61 28 , , , cord-324690-82qsirnk 61 29 placebo placebo NN cord-324690-82qsirnk 61 30 - - HYPH cord-324690-82qsirnk 61 31 controlled control VBN cord-324690-82qsirnk 61 32 , , , cord-324690-82qsirnk 61 33 phase phase NN cord-324690-82qsirnk 61 34 1/2a 1/2a JJ cord-324690-82qsirnk 61 35 clinical clinical JJ cord-324690-82qsirnk 61 36 trial trial NN cord-324690-82qsirnk 61 37 ( ( -LRB- cord-324690-82qsirnk 61 38 APPROACH APPROACH NNP cord-324690-82qsirnk 61 39 ) ) -RRB- cord-324690-82qsirnk 61 40 and and CC cord-324690-82qsirnk 61 41 in in IN cord-324690-82qsirnk 61 42 rhesus rhesu NNS cord-324690-82qsirnk 61 43 monkeys monkey NNS cord-324690-82qsirnk 62 1 ( ( -LRB- cord-324690-82qsirnk 62 2 NHP NHP NNP cord-324690-82qsirnk 62 3 13 13 CD cord-324690-82qsirnk 62 4 - - SYM cord-324690-82qsirnk 62 5 19 19 CD cord-324690-82qsirnk 62 6 ) ) -RRB- cord-324690-82qsirnk 62 7 Increased increase VBN cord-324690-82qsirnk 62 8 valency valency NN cord-324690-82qsirnk 62 9 of of IN cord-324690-82qsirnk 62 10 conserved conserved JJ cord-324690-82qsirnk 62 11 - - HYPH cord-324690-82qsirnk 62 12 mosaic mosaic NN cord-324690-82qsirnk 62 13 vaccines vaccine NNS cord-324690-82qsirnk 62 14 enhances enhance VBZ cord-324690-82qsirnk 62 15 the the DT cord-324690-82qsirnk 62 16 breadth breadth NN cord-324690-82qsirnk 62 17 and and CC cord-324690-82qsirnk 62 18 depth depth NN cord-324690-82qsirnk 62 19 of of IN cord-324690-82qsirnk 62 20 epitope epitope NN cord-324690-82qsirnk 62 21 recognition recognition NN cord-324690-82qsirnk 63 1 A a DT cord-324690-82qsirnk 63 2 live live RB cord-324690-82qsirnk 63 3 - - HYPH cord-324690-82qsirnk 63 4 attenuated attenuated JJ cord-324690-82qsirnk 63 5 RhCMV RhCMV NNP cord-324690-82qsirnk 63 6 / / SYM cord-324690-82qsirnk 63 7 SIV SIV NNP cord-324690-82qsirnk 63 8 vaccine vaccine NN cord-324690-82qsirnk 63 9 shows show VBZ cord-324690-82qsirnk 63 10 long long JJ cord-324690-82qsirnk 63 11 - - HYPH cord-324690-82qsirnk 63 12 term term NN cord-324690-82qsirnk 63 13 efficacy efficacy NN cord-324690-82qsirnk 63 14 against against IN cord-324690-82qsirnk 63 15 heterologous heterologous JJ cord-324690-82qsirnk 63 16 SIV SIV NNP cord-324690-82qsirnk 63 17 challenge challenge NN cord-324690-82qsirnk 63 18 Use Use NNP cord-324690-82qsirnk 63 19 of of IN cord-324690-82qsirnk 63 20 broadly broadly RB cord-324690-82qsirnk 63 21 neutralizing neutralize VBG cord-324690-82qsirnk 63 22 antibodies antibody NNS cord-324690-82qsirnk 63 23 for for IN cord-324690-82qsirnk 63 24 HIV-1 HIV-1 NNP cord-324690-82qsirnk 63 25 prevention prevention NN cord-324690-82qsirnk 63 26 Multiple multiple JJ cord-324690-82qsirnk 63 27 roles role NNS cord-324690-82qsirnk 63 28 for for IN cord-324690-82qsirnk 63 29 HIV HIV NNP cord-324690-82qsirnk 63 30 broadly broadly RB cord-324690-82qsirnk 63 31 neutralizing neutralize VBG cord-324690-82qsirnk 63 32 antibodies antibody NNS cord-324690-82qsirnk 63 33 Safety Safety NNP cord-324690-82qsirnk 63 34 , , , cord-324690-82qsirnk 63 35 pharmacokinetics pharmacokinetic NNS cord-324690-82qsirnk 63 36 and and CC cord-324690-82qsirnk 63 37 neutralization neutralization NN cord-324690-82qsirnk 63 38 of of IN cord-324690-82qsirnk 63 39 the the DT cord-324690-82qsirnk 63 40 broadly broadly RB cord-324690-82qsirnk 63 41 neutralizing neutralize VBG cord-324690-82qsirnk 63 42 HIV-1 HIV-1 NNP cord-324690-82qsirnk 63 43 human human JJ cord-324690-82qsirnk 63 44 monoclonal monoclonal JJ cord-324690-82qsirnk 63 45 antibody antibody NN cord-324690-82qsirnk 63 46 VRC01 VRC01 NNP cord-324690-82qsirnk 63 47 in in IN cord-324690-82qsirnk 63 48 healthy healthy JJ cord-324690-82qsirnk 63 49 adults adult NNS cord-324690-82qsirnk 63 50 HIV-1 HIV-1 NNP cord-324690-82qsirnk 63 51 neutralizing neutralize VBG cord-324690-82qsirnk 63 52 antibody antibody NN cord-324690-82qsirnk 63 53 signatures signature NNS cord-324690-82qsirnk 63 54 and and CC cord-324690-82qsirnk 63 55 application application NN cord-324690-82qsirnk 63 56 to to IN cord-324690-82qsirnk 63 57 epitope epitope NN cord-324690-82qsirnk 63 58 - - HYPH cord-324690-82qsirnk 63 59 targeted target VBN cord-324690-82qsirnk 63 60 vaccine vaccine NN cord-324690-82qsirnk 63 61 design design NN