id sid tid token lemma pos cord-316789-nb4437qs 1 1 key key JJ cord-316789-nb4437qs 1 2 : : : cord-316789-nb4437qs 1 3 cord-316789-nb4437qs cord-316789-nb4437qs CD cord-316789-nb4437qs 1 4 authors author NNS cord-316789-nb4437qs 1 5 : : : cord-316789-nb4437qs 1 6 Omel’yanchuk omel’yanchuk ADD cord-316789-nb4437qs 1 7 , , , cord-316789-nb4437qs 1 8 L. L. NNP cord-316789-nb4437qs 1 9 V. V. NNP cord-316789-nb4437qs 1 10 ; ; : cord-316789-nb4437qs 1 11 Yudina Yudina NNP cord-316789-nb4437qs 1 12 , , , cord-316789-nb4437qs 1 13 O. O. NNP cord-316789-nb4437qs 1 14 S. S. NNP cord-316789-nb4437qs 1 15 title title NN cord-316789-nb4437qs 1 16 : : : cord-316789-nb4437qs 1 17 Drosophila drosophila NN cord-316789-nb4437qs 1 18 melanogaster melanogaster NN cord-316789-nb4437qs 1 19 as as IN cord-316789-nb4437qs 1 20 a a DT cord-316789-nb4437qs 1 21 model model NN cord-316789-nb4437qs 1 22 for for IN cord-316789-nb4437qs 1 23 studying study VBG cord-316789-nb4437qs 1 24 the the DT cord-316789-nb4437qs 1 25 function function NN cord-316789-nb4437qs 1 26 of of IN cord-316789-nb4437qs 1 27 animal animal NN cord-316789-nb4437qs 1 28 viral viral JJ cord-316789-nb4437qs 1 29 proteins protein NNS cord-316789-nb4437qs 1 30 date date NN cord-316789-nb4437qs 1 31 : : : cord-316789-nb4437qs 1 32 2011 2011 CD cord-316789-nb4437qs 1 33 - - SYM cord-316789-nb4437qs 1 34 07 07 CD cord-316789-nb4437qs 1 35 - - HYPH cord-316789-nb4437qs 1 36 16 16 CD cord-316789-nb4437qs 1 37 journal journal NN cord-316789-nb4437qs 1 38 : : : cord-316789-nb4437qs 2 1 Russ Russ NNP cord-316789-nb4437qs 2 2 J J NNP cord-316789-nb4437qs 2 3 Genet Genet NNP cord-316789-nb4437qs 2 4 DOI DOI NNP cord-316789-nb4437qs 2 5 : : : cord-316789-nb4437qs 2 6 10.1134 10.1134 CD cord-316789-nb4437qs 2 7 / / SYM cord-316789-nb4437qs 2 8 s1022795411040090 s1022795411040090 NNP cord-316789-nb4437qs 2 9 sha sha NNP cord-316789-nb4437qs 2 10 : : : cord-316789-nb4437qs 2 11 a1e2a99eb903f9e37a119320d21c890e965f0222 a1e2a99eb903f9e37a119320d21c890e965f0222 NNP cord-316789-nb4437qs 2 12 doc_id doc_id CD cord-316789-nb4437qs 2 13 : : : cord-316789-nb4437qs 2 14 316789 316789 CD cord-316789-nb4437qs 2 15 cord_uid cord_uid NNS cord-316789-nb4437qs 2 16 : : : cord-316789-nb4437qs 2 17 nb4437qs nb4437qs NNP cord-316789-nb4437qs 2 18 Studies Studies NNPS cord-316789-nb4437qs 2 19 in in IN cord-316789-nb4437qs 2 20 which which WDT cord-316789-nb4437qs 2 21 Drosophila drosophila JJ cord-316789-nb4437qs 2 22 melanogaster melanogaster NN cord-316789-nb4437qs 2 23 individuals individual NNS cord-316789-nb4437qs 2 24 carrying carry VBG cord-316789-nb4437qs 2 25 transgenes transgene NNS cord-316789-nb4437qs 2 26 of of IN cord-316789-nb4437qs 2 27 animal animal NN cord-316789-nb4437qs 2 28 viruses virus NNS cord-316789-nb4437qs 2 29 were be VBD cord-316789-nb4437qs 2 30 used use VBN cord-316789-nb4437qs 2 31 to to TO cord-316789-nb4437qs 2 32 analyze analyze VB cord-316789-nb4437qs 2 33 the the DT cord-316789-nb4437qs 2 34 action action NN cord-316789-nb4437qs 2 35 of of IN cord-316789-nb4437qs 2 36 animal animal NN cord-316789-nb4437qs 2 37 viral viral JJ cord-316789-nb4437qs 2 38 proteins protein NNS cord-316789-nb4437qs 2 39 on on IN cord-316789-nb4437qs 2 40 the the DT cord-316789-nb4437qs 2 41 cell cell NN cord-316789-nb4437qs 2 42 are be VBP cord-316789-nb4437qs 2 43 reviewed review VBN cord-316789-nb4437qs 2 44 . . . cord-316789-nb4437qs 3 1 The the DT cord-316789-nb4437qs 3 2 data datum NNS cord-316789-nb4437qs 3 3 presented present VBD cord-316789-nb4437qs 3 4 suggest suggest VBP cord-316789-nb4437qs 3 5 that that IN cord-316789-nb4437qs 3 6 host host NN cord-316789-nb4437qs 3 7 specificity specificity NN cord-316789-nb4437qs 3 8 of of IN cord-316789-nb4437qs 3 9 viruses virus NNS cord-316789-nb4437qs 3 10 is be VBZ cord-316789-nb4437qs 3 11 determined determine VBN cord-316789-nb4437qs 3 12 by by IN cord-316789-nb4437qs 3 13 their -PRON- PRP$ cord-316789-nb4437qs 3 14 proteins protein NNS cord-316789-nb4437qs 3 15 responsible responsible JJ cord-316789-nb4437qs 3 16 for for IN cord-316789-nb4437qs 3 17 the the DT cord-316789-nb4437qs 3 18 penetration penetration NN cord-316789-nb4437qs 3 19 of of IN cord-316789-nb4437qs 3 20 the the DT cord-316789-nb4437qs 3 21 virus virus NN cord-316789-nb4437qs 3 22 into into IN cord-316789-nb4437qs 3 23 the the DT cord-316789-nb4437qs 3 24 cell cell NN cord-316789-nb4437qs 3 25 , , , cord-316789-nb4437qs 3 26 while while IN cord-316789-nb4437qs 3 27 viral viral JJ cord-316789-nb4437qs 3 28 proteins protein NNS cord-316789-nb4437qs 3 29 responsible responsible JJ cord-316789-nb4437qs 3 30 for for IN cord-316789-nb4437qs 3 31 interactions interaction NNS cord-316789-nb4437qs 3 32 with with IN cord-316789-nb4437qs 3 33 the the DT cord-316789-nb4437qs 3 34 host host NN cord-316789-nb4437qs 3 35 cell cell NN cord-316789-nb4437qs 3 36 are be VBP cord-316789-nb4437qs 3 37 much much RB cord-316789-nb4437qs 3 38 less less JJR cord-316789-nb4437qs 3 39 host host NN cord-316789-nb4437qs 3 40 - - HYPH cord-316789-nb4437qs 3 41 specific specific JJ cord-316789-nb4437qs 3 42 . . . cord-316789-nb4437qs 4 1 Due due IN cord-316789-nb4437qs 4 2 to to IN cord-316789-nb4437qs 4 3 this this DT cord-316789-nb4437qs 4 4 , , , cord-316789-nb4437qs 4 5 the the DT cord-316789-nb4437qs 4 6 model model NN cord-316789-nb4437qs 4 7 of of IN cord-316789-nb4437qs 4 8 Drosophila Drosophila NNP cord-316789-nb4437qs 4 9 with with IN cord-316789-nb4437qs 4 10 its -PRON- PRP$ cord-316789-nb4437qs 4 11 developed develop VBN cord-316789-nb4437qs 4 12 system system NN cord-316789-nb4437qs 4 13 of of IN cord-316789-nb4437qs 4 14 searching search VBG cord-316789-nb4437qs 4 15 for for IN cord-316789-nb4437qs 4 16 genetic genetic JJ cord-316789-nb4437qs 4 17 interactions interaction NNS cord-316789-nb4437qs 4 18 can can MD cord-316789-nb4437qs 4 19 be be VB cord-316789-nb4437qs 4 20 used use VBN cord-316789-nb4437qs 4 21 to to TO cord-316789-nb4437qs 4 22 find find VB cord-316789-nb4437qs 4 23 intracellular intracellular JJ cord-316789-nb4437qs 4 24 targets target NNS cord-316789-nb4437qs 4 25 for for IN cord-316789-nb4437qs 4 26 the the DT cord-316789-nb4437qs 4 27 action action NN cord-316789-nb4437qs 4 28 of of IN cord-316789-nb4437qs 4 29 viral viral JJ cord-316789-nb4437qs 4 30 proteins protein NNS cord-316789-nb4437qs 4 31 of of IN cord-316789-nb4437qs 4 32 the the DT cord-316789-nb4437qs 4 33 second second JJ cord-316789-nb4437qs 4 34 group group NN cord-316789-nb4437qs 4 35 . . . cord-316789-nb4437qs 5 1 Drosophila drosophila JJ cord-316789-nb4437qs 5 2 melanogaster melanogaster NN cord-316789-nb4437qs 5 3 is be VBZ cord-316789-nb4437qs 5 4 a a DT cord-316789-nb4437qs 5 5 well well RB cord-316789-nb4437qs 5 6 studied study VBN cord-316789-nb4437qs 5 7 model model NN cord-316789-nb4437qs 5 8 organism organism NN cord-316789-nb4437qs 5 9 containing contain VBG cord-316789-nb4437qs 5 10 ( ( -LRB- cord-316789-nb4437qs 5 11 according accord VBG cord-316789-nb4437qs 5 12 to to IN cord-316789-nb4437qs 5 13 the the DT cord-316789-nb4437qs 5 14 Drosophila Drosophila NNP cord-316789-nb4437qs 5 15 genome genome NN cord-316789-nb4437qs 5 16 project project NN cord-316789-nb4437qs 5 17 ) ) -RRB- cord-316789-nb4437qs 5 18 10000 10000 CD cord-316789-nb4437qs 5 19 - - HYPH cord-316789-nb4437qs 5 20 12000 12000 CD cord-316789-nb4437qs 5 21 genes gene NNS cord-316789-nb4437qs 5 22 [ [ -LRB- cord-316789-nb4437qs 5 23 1 1 CD cord-316789-nb4437qs 5 24 ] ] -RRB- cord-316789-nb4437qs 5 25 . . . cord-316789-nb4437qs 6 1 Many many JJ cord-316789-nb4437qs 6 2 of of IN cord-316789-nb4437qs 6 3 these these DT cord-316789-nb4437qs 6 4 genes gene NNS cord-316789-nb4437qs 6 5 are be VBP cord-316789-nb4437qs 6 6 similar similar JJ cord-316789-nb4437qs 6 7 to to IN cord-316789-nb4437qs 6 8 genes gene NNS cord-316789-nb4437qs 6 9 of of IN cord-316789-nb4437qs 6 10 other other JJ cord-316789-nb4437qs 6 11 animals animal NNS cord-316789-nb4437qs 6 12 as as RB cord-316789-nb4437qs 6 13 well well RB cord-316789-nb4437qs 6 14 as as IN cord-316789-nb4437qs 6 15 to to IN cord-316789-nb4437qs 6 16 human human JJ cord-316789-nb4437qs 6 17 genes gene NNS cord-316789-nb4437qs 6 18 . . . cord-316789-nb4437qs 7 1 It -PRON- PRP cord-316789-nb4437qs 7 2 was be VBD cord-316789-nb4437qs 7 3 found find VBN cord-316789-nb4437qs 7 4 that that IN cord-316789-nb4437qs 7 5 70 70 CD cord-316789-nb4437qs 7 6 % % NN cord-316789-nb4437qs 7 7 of of IN cord-316789-nb4437qs 7 8 Droso Droso NNP cord-316789-nb4437qs 7 9 phila phila NNP cord-316789-nb4437qs 7 10 genes gene NNS cord-316789-nb4437qs 7 11 have have VBP cord-316789-nb4437qs 7 12 human human JJ cord-316789-nb4437qs 7 13 homologs homolog NNS cord-316789-nb4437qs 7 14 [ [ -LRB- cord-316789-nb4437qs 7 15 2 2 CD cord-316789-nb4437qs 7 16 ] ] -RRB- cord-316789-nb4437qs 7 17 and and CC cord-316789-nb4437qs 7 18 75 75 CD cord-316789-nb4437qs 7 19 % % NN cord-316789-nb4437qs 7 20 of of IN cord-316789-nb4437qs 7 21 human human JJ cord-316789-nb4437qs 7 22 disease disease NN cord-316789-nb4437qs 7 23 associated associate VBD cord-316789-nb4437qs 7 24 genes gene NNS cord-316789-nb4437qs 7 25 have have VBP cord-316789-nb4437qs 7 26 homologs homolog NNS cord-316789-nb4437qs 7 27 in in IN cord-316789-nb4437qs 7 28 Drosophila Drosophila NNP cord-316789-nb4437qs 7 29 [ [ -LRB- cord-316789-nb4437qs 7 30 3 3 CD cord-316789-nb4437qs 7 31 ] ] -RRB- cord-316789-nb4437qs 7 32 . . . cord-316789-nb4437qs 8 1 Irrespective irrespective RB cord-316789-nb4437qs 8 2 of of IN cord-316789-nb4437qs 8 3 currently currently RB cord-316789-nb4437qs 8 4 available available JJ cord-316789-nb4437qs 8 5 large large JJ cord-316789-nb4437qs 8 6 collections collection NNS cord-316789-nb4437qs 8 7 of of IN cord-316789-nb4437qs 8 8 mutant mutant JJ cord-316789-nb4437qs 8 9 strains strain NNS cord-316789-nb4437qs 8 10 , , , cord-316789-nb4437qs 8 11 it -PRON- PRP cord-316789-nb4437qs 8 12 becomes become VBZ cord-316789-nb4437qs 8 13 more more JJR cord-316789-nb4437qs 8 14 conve conve NN cord-316789-nb4437qs 8 15 nient nient NN cord-316789-nb4437qs 8 16 to to TO cord-316789-nb4437qs 8 17 study study VB cord-316789-nb4437qs 8 18 the the DT cord-316789-nb4437qs 8 19 function function NN cord-316789-nb4437qs 8 20 of of IN cord-316789-nb4437qs 8 21 Drosophila drosophila JJ cord-316789-nb4437qs 8 22 genes gene NNS cord-316789-nb4437qs 8 23 with with IN cord-316789-nb4437qs 8 24 the the DT cord-316789-nb4437qs 8 25 use use NN cord-316789-nb4437qs 8 26 of of IN cord-316789-nb4437qs 8 27 rather rather RB cord-316789-nb4437qs 8 28 elaborate elaborate JJ cord-316789-nb4437qs 8 29 transgenic transgenic JJ cord-316789-nb4437qs 8 30 constructs construct NNS cord-316789-nb4437qs 8 31 [ [ -LRB- cord-316789-nb4437qs 8 32 4 4 CD cord-316789-nb4437qs 8 33 ] ] -RRB- cord-316789-nb4437qs 8 34 . . . cord-316789-nb4437qs 9 1 The the DT cord-316789-nb4437qs 9 2 system system NN cord-316789-nb4437qs 9 3 of of IN cord-316789-nb4437qs 9 4 ectopic ectopic JJ cord-316789-nb4437qs 9 5 expression expression NN cord-316789-nb4437qs 9 6 of of IN cord-316789-nb4437qs 9 7 Gal4 Gal4 NNP cord-316789-nb4437qs 9 8 UAS UAS NNP cord-316789-nb4437qs 9 9 genes gene NNS cord-316789-nb4437qs 9 10 consists consist VBZ cord-316789-nb4437qs 9 11 of of IN cord-316789-nb4437qs 9 12 two two CD cord-316789-nb4437qs 9 13 components component NNS cord-316789-nb4437qs 9 14 : : : cord-316789-nb4437qs 9 15 a a DT cord-316789-nb4437qs 9 16 driver driver NN cord-316789-nb4437qs 9 17 ( ( -LRB- cord-316789-nb4437qs 9 18 P p NN cord-316789-nb4437qs 9 19 element element NN cord-316789-nb4437qs 9 20 con con NN cord-316789-nb4437qs 9 21 taining taine VBG cord-316789-nb4437qs 9 22 the the DT cord-316789-nb4437qs 9 23 yeast yeast NN cord-316789-nb4437qs 9 24 Gal4 Gal4 NNP cord-316789-nb4437qs 9 25 protein protein NN cord-316789-nb4437qs 9 26 coding code VBG cord-316789-nb4437qs 9 27 region region NN cord-316789-nb4437qs 9 28 under under IN cord-316789-nb4437qs 9 29 the the DT cord-316789-nb4437qs 9 30 control control NN cord-316789-nb4437qs 9 31 of of IN cord-316789-nb4437qs 9 32 the the DT cord-316789-nb4437qs 9 33 genomic genomic JJ cord-316789-nb4437qs 9 34 enhancer enhancer NN cord-316789-nb4437qs 9 35 located locate VBN cord-316789-nb4437qs 9 36 close close RB cord-316789-nb4437qs 9 37 to to IN cord-316789-nb4437qs 9 38 the the DT cord-316789-nb4437qs 9 39 integrated integrate VBN cord-316789-nb4437qs 9 40 element element NN cord-316789-nb4437qs 9 41 ) ) -RRB- cord-316789-nb4437qs 9 42 and and CC cord-316789-nb4437qs 9 43 a a DT cord-316789-nb4437qs 9 44 target target NN cord-316789-nb4437qs 9 45 transgene transgene NN cord-316789-nb4437qs 9 46 under under IN cord-316789-nb4437qs 9 47 the the DT cord-316789-nb4437qs 9 48 control control NN cord-316789-nb4437qs 9 49 of of IN cord-316789-nb4437qs 9 50 the the DT cord-316789-nb4437qs 9 51 Gal4 Gal4 NNP cord-316789-nb4437qs 9 52 specific specific JJ cord-316789-nb4437qs 9 53 promoter promoter NN cord-316789-nb4437qs 9 54 UAS UAS NNP cord-316789-nb4437qs 9 55 ( ( -LRB- cord-316789-nb4437qs 9 56 upstream upstream RB cord-316789-nb4437qs 9 57 activated activate VBN cord-316789-nb4437qs 9 58 system system NN cord-316789-nb4437qs 9 59 ) ) -RRB- cord-316789-nb4437qs 9 60 [ [ -LRB- cord-316789-nb4437qs 9 61 5 5 CD cord-316789-nb4437qs 9 62 ] ] -RRB- cord-316789-nb4437qs 9 63 . . . cord-316789-nb4437qs 10 1 Drosophila Drosophila NNP cord-316789-nb4437qs 10 2 has have VBZ cord-316789-nb4437qs 10 3 a a DT cord-316789-nb4437qs 10 4 set set NN cord-316789-nb4437qs 10 5 of of IN cord-316789-nb4437qs 10 6 drivers driver NNS cord-316789-nb4437qs 10 7 ( ( -LRB- cord-316789-nb4437qs 10 8 hs hs NNP cord-316789-nb4437qs 10 9 Gal4 Gal4 NNP cord-316789-nb4437qs 10 10 ) ) -RRB- cord-316789-nb4437qs 10 11 able able JJ cord-316789-nb4437qs 10 12 to to TO cord-316789-nb4437qs 10 13 activate activate VB cord-316789-nb4437qs 10 14 UAS UAS NNP cord-316789-nb4437qs 10 15 transgenes transgene NNS cord-316789-nb4437qs 10 16 in in IN cord-316789-nb4437qs 10 17 various various JJ cord-316789-nb4437qs 10 18 tissues tissue NNS cord-316789-nb4437qs 10 19 at at IN cord-316789-nb4437qs 10 20 different different JJ cord-316789-nb4437qs 10 21 stages stage NNS cord-316789-nb4437qs 10 22 of of IN cord-316789-nb4437qs 10 23 development development NN cord-316789-nb4437qs 10 24 . . . cord-316789-nb4437qs 11 1 There there EX cord-316789-nb4437qs 11 2 is be VBZ cord-316789-nb4437qs 11 3 also also RB cord-316789-nb4437qs 11 4 a a DT cord-316789-nb4437qs 11 5 possibility possibility NN cord-316789-nb4437qs 11 6 to to TO cord-316789-nb4437qs 11 7 activate activate VB cord-316789-nb4437qs 11 8 the the DT cord-316789-nb4437qs 11 9 tissue tissue NN cord-316789-nb4437qs 11 10 specific specific JJ cord-316789-nb4437qs 11 11 transgene transgene NN cord-316789-nb4437qs 11 12 conditionally conditionally RB cord-316789-nb4437qs 11 13 using use VBG cord-316789-nb4437qs 11 14 an an DT cord-316789-nb4437qs 11 15 external external JJ cord-316789-nb4437qs 11 16 stimulus stimulus NN cord-316789-nb4437qs 11 17 and and CC cord-316789-nb4437qs 11 18 even even RB cord-316789-nb4437qs 11 19 to to TO cord-316789-nb4437qs 11 20 form form VB cord-316789-nb4437qs 11 21 a a DT cord-316789-nb4437qs 11 22 feedback feedback NN cord-316789-nb4437qs 11 23 loop loop NN cord-316789-nb4437qs 11 24 for for IN cord-316789-nb4437qs 11 25 autoactivation autoactivation NN cord-316789-nb4437qs 11 26 of of IN cord-316789-nb4437qs 11 27 the the DT cord-316789-nb4437qs 11 28 trans trans NNP cord-316789-nb4437qs 11 29 gene gene NN cord-316789-nb4437qs 11 30 ( ( -LRB- cord-316789-nb4437qs 11 31 UAS UAS NNP cord-316789-nb4437qs 11 32 Gal4 Gal4 NNP cord-316789-nb4437qs 11 33 ) ) -RRB- cord-316789-nb4437qs 11 34 . . . cord-316789-nb4437qs 12 1 These these DT cord-316789-nb4437qs 12 2 possibilities possibility NNS cord-316789-nb4437qs 12 3 , , , cord-316789-nb4437qs 12 4 initially initially RB cord-316789-nb4437qs 12 5 devel devel NN cord-316789-nb4437qs 12 6 oped oped NN cord-316789-nb4437qs 12 7 for for IN cord-316789-nb4437qs 12 8 genetic genetic JJ cord-316789-nb4437qs 12 9 analysis analysis NN cord-316789-nb4437qs 12 10 of of IN cord-316789-nb4437qs 12 11 Drosophila drosophila JJ cord-316789-nb4437qs 12 12 genes gene NNS cord-316789-nb4437qs 12 13 , , , cord-316789-nb4437qs 12 14 can can MD cord-316789-nb4437qs 12 15 also also RB cord-316789-nb4437qs 12 16 be be VB cord-316789-nb4437qs 12 17 used use VBN cord-316789-nb4437qs 12 18 to to TO cord-316789-nb4437qs 12 19 analyze analyze VB cord-316789-nb4437qs 12 20 the the DT cord-316789-nb4437qs 12 21 functions function NNS cord-316789-nb4437qs 12 22 of of IN cord-316789-nb4437qs 12 23 foreign foreign JJ cord-316789-nb4437qs 12 24 genes gene NNS cord-316789-nb4437qs 12 25 . . . cord-316789-nb4437qs 13 1 Viral viral JJ cord-316789-nb4437qs 13 2 genomes genome NNS cord-316789-nb4437qs 13 3 can can MD cord-316789-nb4437qs 13 4 maximally maximally RB cord-316789-nb4437qs 13 5 encode encode VB cord-316789-nb4437qs 13 6 four four CD cord-316789-nb4437qs 13 7 to to IN cord-316789-nb4437qs 13 8 sev sev NNP cord-316789-nb4437qs 13 9 eral eral JJ cord-316789-nb4437qs 13 10 hundred hundred CD cord-316789-nb4437qs 13 11 proteins protein NNS cord-316789-nb4437qs 13 12 ( ( -LRB- cord-316789-nb4437qs 13 13 the the DT cord-316789-nb4437qs 13 14 genome genome NN cord-316789-nb4437qs 13 15 of of IN cord-316789-nb4437qs 13 16 Mimivirus Mimivirus NNP cord-316789-nb4437qs 13 17 is be VBZ cord-316789-nb4437qs 13 18 1.2 1.2 CD cord-316789-nb4437qs 13 19 megabases megabase NNS cord-316789-nb4437qs 13 20 in in IN cord-316789-nb4437qs 13 21 size size NN cord-316789-nb4437qs 13 22 and and CC cord-316789-nb4437qs 13 23 contains contain VBZ cord-316789-nb4437qs 13 24 1262 1262 CD cord-316789-nb4437qs 13 25 reading read VBG cord-316789-nb4437qs 13 26 frames frame NNS cord-316789-nb4437qs 13 27 corresponding correspond VBG cord-316789-nb4437qs 13 28 to to IN cord-316789-nb4437qs 13 29 911 911 CD cord-316789-nb4437qs 13 30 proteins protein NNS cord-316789-nb4437qs 13 31 [ [ -LRB- cord-316789-nb4437qs 13 32 6 6 CD cord-316789-nb4437qs 13 33 ] ] -RRB- cord-316789-nb4437qs 13 34 ) ) -RRB- cord-316789-nb4437qs 13 35 , , , cord-316789-nb4437qs 13 36 although although IN cord-316789-nb4437qs 13 37 most most JJS cord-316789-nb4437qs 13 38 typical typical JJ cord-316789-nb4437qs 13 39 is be VBZ cord-316789-nb4437qs 13 40 the the DT cord-316789-nb4437qs 13 41 influenza influenza NN cord-316789-nb4437qs 13 42 virus virus NN cord-316789-nb4437qs 13 43 encoding encode VBG cord-316789-nb4437qs 13 44 11 11 CD cord-316789-nb4437qs 13 45 proteins protein NNS cord-316789-nb4437qs 13 46 [ [ -LRB- cord-316789-nb4437qs 13 47 7 7 CD cord-316789-nb4437qs 13 48 ] ] -RRB- cord-316789-nb4437qs 13 49 . . . cord-316789-nb4437qs 14 1 Viral viral JJ cord-316789-nb4437qs 14 2 genomes genome NNS cord-316789-nb4437qs 14 3 encode encode VBP cord-316789-nb4437qs 14 4 viral viral JJ cord-316789-nb4437qs 14 5 envelope envelope NN cord-316789-nb4437qs 14 6 proteins protein NNS cord-316789-nb4437qs 14 7 responsible responsible JJ cord-316789-nb4437qs 14 8 for for IN cord-316789-nb4437qs 14 9 interactions interaction NNS cord-316789-nb4437qs 14 10 of of IN cord-316789-nb4437qs 14 11 the the DT cord-316789-nb4437qs 14 12 virus virus NN cord-316789-nb4437qs 14 13 with with IN cord-316789-nb4437qs 14 14 the the DT cord-316789-nb4437qs 14 15 host host NN cord-316789-nb4437qs 14 16 cell cell NN cord-316789-nb4437qs 14 17 at at IN cord-316789-nb4437qs 14 18 the the DT cord-316789-nb4437qs 14 19 stage stage NN cord-316789-nb4437qs 14 20 of of IN cord-316789-nb4437qs 14 21 penetration penetration NN cord-316789-nb4437qs 14 22 into into IN cord-316789-nb4437qs 14 23 the the DT cord-316789-nb4437qs 14 24 cell cell NN cord-316789-nb4437qs 14 25 . . . cord-316789-nb4437qs 15 1 At at IN cord-316789-nb4437qs 15 2 the the DT cord-316789-nb4437qs 15 3 same same JJ cord-316789-nb4437qs 15 4 time time NN cord-316789-nb4437qs 15 5 , , , cord-316789-nb4437qs 15 6 it -PRON- PRP cord-316789-nb4437qs 15 7 is be VBZ cord-316789-nb4437qs 15 8 commonly commonly RB cord-316789-nb4437qs 15 9 known know VBN cord-316789-nb4437qs 15 10 that that IN cord-316789-nb4437qs 15 11 in in IN cord-316789-nb4437qs 15 12 addition addition NN cord-316789-nb4437qs 15 13 to to IN cord-316789-nb4437qs 15 14 these these DT cord-316789-nb4437qs 15 15 proteins protein NNS cord-316789-nb4437qs 15 16 serving serve VBG cord-316789-nb4437qs 15 17 the the DT cord-316789-nb4437qs 15 18 structural structural JJ cord-316789-nb4437qs 15 19 function function NN cord-316789-nb4437qs 15 20 viral viral JJ cord-316789-nb4437qs 15 21 genomes genome NNS cord-316789-nb4437qs 15 22 contain contain VBP cord-316789-nb4437qs 15 23 genes gene NNS cord-316789-nb4437qs 15 24 responsible responsible JJ cord-316789-nb4437qs 15 25 for for IN cord-316789-nb4437qs 15 26 finer fine JJR cord-316789-nb4437qs 15 27 aspects aspect NNS cord-316789-nb4437qs 15 28 of of IN cord-316789-nb4437qs 15 29 interaction interaction NN cord-316789-nb4437qs 15 30 with with IN cord-316789-nb4437qs 15 31 host host NN cord-316789-nb4437qs 15 32 cells cell NNS cord-316789-nb4437qs 15 33 : : : cord-316789-nb4437qs 15 34 cell cell NN cord-316789-nb4437qs 15 35 proliferation proliferation NN cord-316789-nb4437qs 15 36 ( ( -LRB- cord-316789-nb4437qs 15 37 in in IN cord-316789-nb4437qs 15 38 fact fact NN cord-316789-nb4437qs 15 39 , , , cord-316789-nb4437qs 15 40 isolation isolation NN cord-316789-nb4437qs 15 41 of of IN cord-316789-nb4437qs 15 42 oncogenes oncogene NNS cord-316789-nb4437qs 15 43 was be VBD cord-316789-nb4437qs 15 44 made make VBN cord-316789-nb4437qs 15 45 on on IN cord-316789-nb4437qs 15 46 the the DT cord-316789-nb4437qs 15 47 basis basis NN cord-316789-nb4437qs 15 48 of of IN cord-316789-nb4437qs 15 49 this this DT cord-316789-nb4437qs 15 50 property property NN cord-316789-nb4437qs 15 51 ) ) -RRB- cord-316789-nb4437qs 15 52 and and CC cord-316789-nb4437qs 15 53 cell cell NN cord-316789-nb4437qs 15 54 apoptosis apoptosis NN cord-316789-nb4437qs 15 55 . . . cord-316789-nb4437qs 16 1 In in IN cord-316789-nb4437qs 16 2 this this DT cord-316789-nb4437qs 16 3 work work NN cord-316789-nb4437qs 16 4 , , , cord-316789-nb4437qs 16 5 we -PRON- PRP cord-316789-nb4437qs 16 6 review review VBP cord-316789-nb4437qs 16 7 the the DT cord-316789-nb4437qs 16 8 results result NNS cord-316789-nb4437qs 16 9 and and CC cord-316789-nb4437qs 16 10 methodical methodical JJ cord-316789-nb4437qs 16 11 approaches approach NNS cord-316789-nb4437qs 16 12 of of IN cord-316789-nb4437qs 16 13 studies study NNS cord-316789-nb4437qs 16 14 in in IN cord-316789-nb4437qs 16 15 which which WDT cord-316789-nb4437qs 16 16 Drosophila Drosophila NNP cord-316789-nb4437qs 16 17 was be VBD cord-316789-nb4437qs 16 18 used use VBN cord-316789-nb4437qs 16 19 to to TO cord-316789-nb4437qs 16 20 analyze analyze VB cord-316789-nb4437qs 16 21 human human JJ cord-316789-nb4437qs 16 22 viral viral JJ cord-316789-nb4437qs 16 23 infections infection NNS cord-316789-nb4437qs 16 24 . . . cord-316789-nb4437qs 17 1 Drosophila Drosophila NNP cord-316789-nb4437qs 17 2 was be VBD cord-316789-nb4437qs 17 3 successfully successfully RB cord-316789-nb4437qs 17 4 used use VBN cord-316789-nb4437qs 17 5 to to TO cord-316789-nb4437qs 17 6 study study VB cord-316789-nb4437qs 17 7 viral viral JJ cord-316789-nb4437qs 17 8 genes gene NNS cord-316789-nb4437qs 17 9 and and CC cord-316789-nb4437qs 17 10 proteins protein NNS cord-316789-nb4437qs 17 11 inhibiting inhibit VBG cord-316789-nb4437qs 17 12 programmed program VBN cord-316789-nb4437qs 17 13 death death NN cord-316789-nb4437qs 17 14 ( ( -LRB- cord-316789-nb4437qs 17 15 apoptosis apoptosis NN cord-316789-nb4437qs 17 16 ) ) -RRB- cord-316789-nb4437qs 17 17 of of IN cord-316789-nb4437qs 17 18 host host NN cord-316789-nb4437qs 17 19 cells cell NNS cord-316789-nb4437qs 17 20 . . . cord-316789-nb4437qs 18 1 Animal animal NN cord-316789-nb4437qs 18 2 viruses virus NNS cord-316789-nb4437qs 18 3 are be VBP cord-316789-nb4437qs 18 4 known know VBN cord-316789-nb4437qs 18 5 to to TO cord-316789-nb4437qs 18 6 carry carry VB cord-316789-nb4437qs 18 7 genes gene NNS cord-316789-nb4437qs 18 8 able able JJ cord-316789-nb4437qs 18 9 to to TO cord-316789-nb4437qs 18 10 prevent prevent VB cord-316789-nb4437qs 18 11 apoptosis apoptosis NN cord-316789-nb4437qs 18 12 of of IN cord-316789-nb4437qs 18 13 host host NN cord-316789-nb4437qs 18 14 cells cell NNS cord-316789-nb4437qs 18 15 [ [ -LRB- cord-316789-nb4437qs 18 16 8 8 CD cord-316789-nb4437qs 18 17 ] ] -RRB- cord-316789-nb4437qs 18 18 [ [ -LRB- cord-316789-nb4437qs 18 19 9 9 CD cord-316789-nb4437qs 18 20 ] ] -RRB- cord-316789-nb4437qs 19 1 [ [ -LRB- cord-316789-nb4437qs 19 2 10 10 CD cord-316789-nb4437qs 19 3 ] ] -RRB- cord-316789-nb4437qs 19 4 [ [ -LRB- cord-316789-nb4437qs 19 5 11 11 CD cord-316789-nb4437qs 19 6 ] ] -RRB- cord-316789-nb4437qs 19 7 [ [ -LRB- cord-316789-nb4437qs 19 8 12 12 CD cord-316789-nb4437qs 19 9 ] ] -RRB- cord-316789-nb4437qs 19 10 [ [ -LRB- cord-316789-nb4437qs 19 11 13 13 CD cord-316789-nb4437qs 19 12 ] ] -RRB- cord-316789-nb4437qs 20 1 [ [ -LRB- cord-316789-nb4437qs 20 2 14 14 CD cord-316789-nb4437qs 20 3 ] ] -RRB- cord-316789-nb4437qs 20 4 [ [ -LRB- cord-316789-nb4437qs 20 5 15 15 CD cord-316789-nb4437qs 20 6 ] ] -RRB- cord-316789-nb4437qs 20 7 [ [ -LRB- cord-316789-nb4437qs 20 8 16 16 CD cord-316789-nb4437qs 20 9 ] ] -RRB- cord-316789-nb4437qs 20 10 . . . cord-316789-nb4437qs 21 1 On on IN cord-316789-nb4437qs 21 2 this this DT cord-316789-nb4437qs 21 3 basis basis NN cord-316789-nb4437qs 21 4 , , , cord-316789-nb4437qs 21 5 Hay Hay NNP cord-316789-nb4437qs 21 6 et et FW cord-316789-nb4437qs 21 7 al al NNP cord-316789-nb4437qs 21 8 . . . cord-316789-nb4437qs 22 1 [ [ -LRB- cord-316789-nb4437qs 22 2 17 17 CD cord-316789-nb4437qs 22 3 ] ] -RRB- cord-316789-nb4437qs 22 4 cloned clone VBD cord-316789-nb4437qs 22 5 the the DT cord-316789-nb4437qs 22 6 gene gene NN cord-316789-nb4437qs 22 7 P35 P35 NNP cord-316789-nb4437qs 22 8 of of IN cord-316789-nb4437qs 22 9 the the DT cord-316789-nb4437qs 22 10 Autographa Autographa NNP cord-316789-nb4437qs 22 11 californica californica NN cord-316789-nb4437qs 22 12 baculovirus baculovirus NN cord-316789-nb4437qs 22 13 in in IN cord-316789-nb4437qs 22 14 the the DT cord-316789-nb4437qs 22 15 pGMR pgmr JJ cord-316789-nb4437qs 22 16 ( ( -LRB- cord-316789-nb4437qs 22 17 glass glass NN cord-316789-nb4437qs 22 18 multimer multimer NNP cord-316789-nb4437qs 22 19 reporter reporter NN cord-316789-nb4437qs 22 20 ) ) -RRB- cord-316789-nb4437qs 22 21 vector vector NN cord-316789-nb4437qs 22 22 able able JJ cord-316789-nb4437qs 22 23 to to TO cord-316789-nb4437qs 22 24 pro pro VB cord-316789-nb4437qs 22 25 vide vide NN cord-316789-nb4437qs 22 26 transgene transgene NN cord-316789-nb4437qs 22 27 overexpression overexpression NN cord-316789-nb4437qs 22 28 in in IN cord-316789-nb4437qs 22 29 the the DT cord-316789-nb4437qs 22 30 eye eye NN cord-316789-nb4437qs 22 31 . . . cord-316789-nb4437qs 23 1 The the DT cord-316789-nb4437qs 23 2 effect effect NN cord-316789-nb4437qs 23 3 of of IN cord-316789-nb4437qs 23 4 transgene transgene NN cord-316789-nb4437qs 23 5 overexpression overexpression NN cord-316789-nb4437qs 23 6 in in IN cord-316789-nb4437qs 23 7 embryogenesis embryogenesis NN cord-316789-nb4437qs 23 8 was be VBD cord-316789-nb4437qs 23 9 exam exam NN cord-316789-nb4437qs 23 10 ined ine VBN cord-316789-nb4437qs 23 11 in in IN cord-316789-nb4437qs 23 12 individuals individual NNS cord-316789-nb4437qs 23 13 containing contain VBG cord-316789-nb4437qs 23 14 an an DT cord-316789-nb4437qs 23 15 insertion insertion NN cord-316789-nb4437qs 23 16 of of IN cord-316789-nb4437qs 23 17 this this DT cord-316789-nb4437qs 23 18 vec vec FW cord-316789-nb4437qs 23 19 tor tor NN cord-316789-nb4437qs 23 20 and and CC cord-316789-nb4437qs 23 21 additionally additionally RB cord-316789-nb4437qs 23 22 carrying carry VBG cord-316789-nb4437qs 23 23 the the DT cord-316789-nb4437qs 23 24 hs hs NNP cord-316789-nb4437qs 23 25 glass glass NN cord-316789-nb4437qs 23 26 transgene transgene NN cord-316789-nb4437qs 23 27 capable capable JJ cord-316789-nb4437qs 23 28 of of IN cord-316789-nb4437qs 23 29 activating activate VBG cord-316789-nb4437qs 23 30 the the DT cord-316789-nb4437qs 23 31 pGMR pgmr JJ cord-316789-nb4437qs 23 32 transgene transgene NN cord-316789-nb4437qs 23 33 in in IN cord-316789-nb4437qs 23 34 all all DT cord-316789-nb4437qs 23 35 tissues tissue NNS cord-316789-nb4437qs 23 36 under under IN cord-316789-nb4437qs 23 37 the the DT cord-316789-nb4437qs 23 38 action action NN cord-316789-nb4437qs 23 39 of of IN cord-316789-nb4437qs 23 40 heat heat NN cord-316789-nb4437qs 23 41 shock shock NN cord-316789-nb4437qs 23 42 . . . cord-316789-nb4437qs 24 1 Heat heat NN cord-316789-nb4437qs 24 2 shock shock NN cord-316789-nb4437qs 24 3 induction induction NN cord-316789-nb4437qs 24 4 in in IN cord-316789-nb4437qs 24 5 such such JJ cord-316789-nb4437qs 24 6 individuals individual NNS cord-316789-nb4437qs 24 7 resulted result VBD cord-316789-nb4437qs 24 8 in in IN cord-316789-nb4437qs 24 9 the the DT cord-316789-nb4437qs 24 10 lack lack NN cord-316789-nb4437qs 24 11 of of IN cord-316789-nb4437qs 24 12 apoptosis apoptosis NN cord-316789-nb4437qs 24 13 in in IN cord-316789-nb4437qs 24 14 late late JJ cord-316789-nb4437qs 24 15 embryos embryo NNS cord-316789-nb4437qs 24 16 , , , cord-316789-nb4437qs 24 17 while while IN cord-316789-nb4437qs 24 18 it -PRON- PRP cord-316789-nb4437qs 24 19 is be VBZ cord-316789-nb4437qs 24 20 normally normally RB cord-316789-nb4437qs 24 21 observed observe VBN cord-316789-nb4437qs 24 22 in in IN cord-316789-nb4437qs 24 23 wild wild JJ cord-316789-nb4437qs 24 24 type type NN cord-316789-nb4437qs 24 25 individuals individual NNS cord-316789-nb4437qs 24 26 [ [ -LRB- cord-316789-nb4437qs 24 27 18 18 CD cord-316789-nb4437qs 24 28 ] ] -RRB- cord-316789-nb4437qs 24 29 . . . cord-316789-nb4437qs 25 1 To to TO cord-316789-nb4437qs 25 2 study study VB cord-316789-nb4437qs 25 3 apoptosis apoptosis NN cord-316789-nb4437qs 25 4 of of IN cord-316789-nb4437qs 25 5 eye eye NN cord-316789-nb4437qs 25 6 cells cell NNS cord-316789-nb4437qs 25 7 , , , cord-316789-nb4437qs 25 8 activation activation NN cord-316789-nb4437qs 25 9 of of IN cord-316789-nb4437qs 25 10 the the DT cord-316789-nb4437qs 25 11 pGMR pgmr JJ cord-316789-nb4437qs 25 12 transgene transgene NN cord-316789-nb4437qs 25 13 was be VBD cord-316789-nb4437qs 25 14 used use VBN cord-316789-nb4437qs 25 15 . . . cord-316789-nb4437qs 26 1 Inhibition inhibition NN cord-316789-nb4437qs 26 2 of of IN cord-316789-nb4437qs 26 3 apoptosis apoptosis NN cord-316789-nb4437qs 26 4 characteristic characteristic NN cord-316789-nb4437qs 26 5 of of IN cord-316789-nb4437qs 26 6 normal normal JJ cord-316789-nb4437qs 26 7 development development NN cord-316789-nb4437qs 26 8 was be VBD cord-316789-nb4437qs 26 9 demonstrated demonstrate VBN cord-316789-nb4437qs 26 10 on on IN cord-316789-nb4437qs 26 11 the the DT cord-316789-nb4437qs 26 12 level level NN cord-316789-nb4437qs 26 13 of of IN cord-316789-nb4437qs 26 14 eye eye NN cord-316789-nb4437qs 26 15 morphology morphology NN cord-316789-nb4437qs 26 16 of of IN cord-316789-nb4437qs 26 17 an an DT cord-316789-nb4437qs 26 18 adult adult NN cord-316789-nb4437qs 26 19 individual individual NN cord-316789-nb4437qs 26 20 and and CC cord-316789-nb4437qs 26 21 on on IN cord-316789-nb4437qs 26 22 the the DT cord-316789-nb4437qs 26 23 imaginal imaginal JJ cord-316789-nb4437qs 26 24 disc disc NN cord-316789-nb4437qs 26 25 level level NN cord-316789-nb4437qs 26 26 . . . cord-316789-nb4437qs 27 1 Inhibi Inhibi NNP cord-316789-nb4437qs 27 2 OMEL'YANCHUK omel'yanchuk NN cord-316789-nb4437qs 27 3 , , , cord-316789-nb4437qs 27 4 YUDINA YUDINA NNP cord-316789-nb4437qs 27 5 tion tion NN cord-316789-nb4437qs 27 6 of of IN cord-316789-nb4437qs 27 7 apoptosis apoptosis NN cord-316789-nb4437qs 27 8 induced induce VBN cord-316789-nb4437qs 27 9 by by IN cord-316789-nb4437qs 27 10 X x NN cord-316789-nb4437qs 27 11 irradiation irradiation NN cord-316789-nb4437qs 27 12 was be VBD cord-316789-nb4437qs 27 13 also also RB cord-316789-nb4437qs 27 14 demonstrated demonstrate VBN cord-316789-nb4437qs 27 15 . . . cord-316789-nb4437qs 28 1 At at IN cord-316789-nb4437qs 28 2 present present NN cord-316789-nb4437qs 28 3 , , , cord-316789-nb4437qs 28 4 constructs construct NNS cord-316789-nb4437qs 28 5 based base VBN cord-316789-nb4437qs 28 6 on on IN cord-316789-nb4437qs 28 7 P35 P35 NNP cord-316789-nb4437qs 28 8 serve serve VBP cord-316789-nb4437qs 28 9 as as IN cord-316789-nb4437qs 28 10 a a DT cord-316789-nb4437qs 28 11 commonly commonly RB cord-316789-nb4437qs 28 12 accepted accept VBN cord-316789-nb4437qs 28 13 test test NN cord-316789-nb4437qs 28 14 for for IN cord-316789-nb4437qs 28 15 classifying classify VBG cord-316789-nb4437qs 28 16 cell cell NN cord-316789-nb4437qs 28 17 death death NN cord-316789-nb4437qs 28 18 as as IN cord-316789-nb4437qs 28 19 apoptosis apoptosis NN cord-316789-nb4437qs 28 20 . . . cord-316789-nb4437qs 29 1 Drosophila Drosophila NNP cord-316789-nb4437qs 29 2 was be VBD cord-316789-nb4437qs 29 3 successfully successfully RB cord-316789-nb4437qs 29 4 used use VBN cord-316789-nb4437qs 29 5 to to TO cord-316789-nb4437qs 29 6 study study VB cord-316789-nb4437qs 29 7 HIV HIV NNP cord-316789-nb4437qs 29 8 infec infec IN cord-316789-nb4437qs 29 9 tion tion NN cord-316789-nb4437qs 29 10 . . . cord-316789-nb4437qs 30 1 The the DT cord-316789-nb4437qs 30 2 authors author NNS cord-316789-nb4437qs 30 3 of of IN cord-316789-nb4437qs 30 4 the the DT cord-316789-nb4437qs 30 5 work work NN cord-316789-nb4437qs 30 6 [ [ -LRB- cord-316789-nb4437qs 30 7 19 19 CD cord-316789-nb4437qs 30 8 ] ] -RRB- cord-316789-nb4437qs 30 9 cloned clone VBD cord-316789-nb4437qs 30 10 the the DT cord-316789-nb4437qs 30 11 HIV HIV NNP cord-316789-nb4437qs 30 12 tat tat NN cord-316789-nb4437qs 30 13 gene gene NN cord-316789-nb4437qs 30 14 in in IN cord-316789-nb4437qs 30 15 the the DT cord-316789-nb4437qs 30 16 pCasPeR pcasper JJ cord-316789-nb4437qs 30 17 vector vector NN cord-316789-nb4437qs 30 18 containing contain VBG cord-316789-nb4437qs 30 19 the the DT cord-316789-nb4437qs 30 20 hs hs NNP cord-316789-nb4437qs 30 21 promoter promoter NN cord-316789-nb4437qs 30 22 capable capable JJ cord-316789-nb4437qs 30 23 of of IN cord-316789-nb4437qs 30 24 heat heat NN cord-316789-nb4437qs 30 25 shock shock NN cord-316789-nb4437qs 30 26 activation activation NN cord-316789-nb4437qs 30 27 of of IN cord-316789-nb4437qs 30 28 transgene transgene JJ cord-316789-nb4437qs 30 29 expression expression NN cord-316789-nb4437qs 30 30 in in IN cord-316789-nb4437qs 30 31 all all DT cord-316789-nb4437qs 30 32 tissues tissue NNS cord-316789-nb4437qs 30 33 . . . cord-316789-nb4437qs 31 1 Activation activation NN cord-316789-nb4437qs 31 2 of of IN cord-316789-nb4437qs 31 3 the the DT cord-316789-nb4437qs 31 4 transgene transgene NN cord-316789-nb4437qs 31 5 in in IN cord-316789-nb4437qs 31 6 oogenesis oogenesis NN cord-316789-nb4437qs 31 7 resulted result VBD cord-316789-nb4437qs 31 8 in in IN cord-316789-nb4437qs 31 9 an an DT cord-316789-nb4437qs 31 10 essential essential JJ cord-316789-nb4437qs 31 11 increase increase NN cord-316789-nb4437qs 31 12 ( ( -LRB- cord-316789-nb4437qs 31 13 from from IN cord-316789-nb4437qs 31 14 1 1 CD cord-316789-nb4437qs 31 15 to to IN cord-316789-nb4437qs 31 16 10 10 CD cord-316789-nb4437qs 31 17 % % NN cord-316789-nb4437qs 31 18 ) ) -RRB- cord-316789-nb4437qs 31 19 of of IN cord-316789-nb4437qs 31 20 the the DT cord-316789-nb4437qs 31 21 share share NN cord-316789-nb4437qs 31 22 of of IN cord-316789-nb4437qs 31 23 eggs egg NNS cord-316789-nb4437qs 31 24 with with IN cord-316789-nb4437qs 31 25 the the DT cord-316789-nb4437qs 31 26 phenotype phenotype NN cord-316789-nb4437qs 31 27 of of IN cord-316789-nb4437qs 31 28 fused fuse VBN cord-316789-nb4437qs 31 29 dorsal dorsal JJ cord-316789-nb4437qs 31 30 appendages appendage NNS cord-316789-nb4437qs 31 31 . . . cord-316789-nb4437qs 32 1 The the DT cord-316789-nb4437qs 32 2 authors author NNS cord-316789-nb4437qs 32 3 found find VBD cord-316789-nb4437qs 32 4 that that IN cord-316789-nb4437qs 32 5 the the DT cord-316789-nb4437qs 32 6 Tat Tat NNP cord-316789-nb4437qs 32 7 protein protein NN cord-316789-nb4437qs 32 8 affects affect VBZ cord-316789-nb4437qs 32 9 the the DT cord-316789-nb4437qs 32 10 localization localization NN cord-316789-nb4437qs 32 11 of of IN cord-316789-nb4437qs 32 12 the the DT cord-316789-nb4437qs 32 13 Gurken Gurken NNP cord-316789-nb4437qs 32 14 and and CC cord-316789-nb4437qs 32 15 Kinesin Kinesin NNP cord-316789-nb4437qs 32 16 pro pro JJ cord-316789-nb4437qs 32 17 teins tein NNS cord-316789-nb4437qs 32 18 , , , cord-316789-nb4437qs 32 19 i. i. NNP cord-316789-nb4437qs 32 20 e. e. NNP cord-316789-nb4437qs 32 21 , , , cord-316789-nb4437qs 32 22 it -PRON- PRP cord-316789-nb4437qs 32 23 alters alter VBZ cord-316789-nb4437qs 32 24 both both CC cord-316789-nb4437qs 32 25 the the DT cord-316789-nb4437qs 32 26 dorsoventral dorsoventral JJ cord-316789-nb4437qs 32 27 and and CC cord-316789-nb4437qs 32 28 anteropos anteropos NNP cord-316789-nb4437qs 32 29 terior terior JJ cord-316789-nb4437qs 32 30 axes axis NNS cord-316789-nb4437qs 32 31 of of IN cord-316789-nb4437qs 32 32 embryos embryo NNS cord-316789-nb4437qs 32 33 . . . cord-316789-nb4437qs 33 1 Activation activation NN cord-316789-nb4437qs 33 2 of of IN cord-316789-nb4437qs 33 3 transgene transgene NN cord-316789-nb4437qs 33 4 expres expres NNP cord-316789-nb4437qs 33 5 sion sion NNP cord-316789-nb4437qs 33 6 in in IN cord-316789-nb4437qs 33 7 spermatogenesis spermatogenesis NN cord-316789-nb4437qs 33 8 showed show VBD cord-316789-nb4437qs 33 9 colocalization colocalization NN cord-316789-nb4437qs 33 10 of of IN cord-316789-nb4437qs 33 11 Tat Tat NNP cord-316789-nb4437qs 33 12 with with IN cord-316789-nb4437qs 33 13 alfa alfa NNP cord-316789-nb4437qs 33 14 tubulin tubulin NNP cord-316789-nb4437qs 33 15 . . . cord-316789-nb4437qs 34 1 Furthermore furthermore RB cord-316789-nb4437qs 34 2 , , , cord-316789-nb4437qs 34 3 the the DT cord-316789-nb4437qs 34 4 authors author NNS cord-316789-nb4437qs 34 5 established establish VBN cord-316789-nb4437qs 34 6 in in IN cord-316789-nb4437qs 34 7 an an DT cord-316789-nb4437qs 34 8 in in FW cord-316789-nb4437qs 34 9 vitro vitro FW cord-316789-nb4437qs 34 10 experiment experiment NN cord-316789-nb4437qs 34 11 that that WDT cord-316789-nb4437qs 34 12 Tat Tat NNP cord-316789-nb4437qs 34 13 inhibits inhibit VBZ cord-316789-nb4437qs 34 14 the the DT cord-316789-nb4437qs 34 15 assembly assembly NN cord-316789-nb4437qs 34 16 of of IN cord-316789-nb4437qs 34 17 microtubules microtubule NNS cord-316789-nb4437qs 34 18 . . . cord-316789-nb4437qs 35 1 The the DT cord-316789-nb4437qs 35 2 study study NN cord-316789-nb4437qs 35 3 of of IN cord-316789-nb4437qs 35 4 the the DT cord-316789-nb4437qs 35 5 viral viral JJ cord-316789-nb4437qs 35 6 protein protein NN cord-316789-nb4437qs 35 7 in in IN cord-316789-nb4437qs 35 8 accor accor NNP cord-316789-nb4437qs 35 9 dance dance NNP cord-316789-nb4437qs 35 10 to to IN cord-316789-nb4437qs 35 11 the the DT cord-316789-nb4437qs 35 12 commonly commonly RB cord-316789-nb4437qs 35 13 accepted accept VBN cord-316789-nb4437qs 35 14 scheme scheme NN cord-316789-nb4437qs 35 15 showed show VBD cord-316789-nb4437qs 35 16 that that IN cord-316789-nb4437qs 35 17 it -PRON- PRP cord-316789-nb4437qs 35 18 functions function VBZ cord-316789-nb4437qs 35 19 in in IN cord-316789-nb4437qs 35 20 the the DT cord-316789-nb4437qs 35 21 process process NN cord-316789-nb4437qs 35 22 of of IN cord-316789-nb4437qs 35 23 viral viral JJ cord-316789-nb4437qs 35 24 RNA RNA NNP cord-316789-nb4437qs 35 25 translation translation NN cord-316789-nb4437qs 35 26 [ [ -LRB- cord-316789-nb4437qs 35 27 20 20 CD cord-316789-nb4437qs 35 28 ] ] -RRB- cord-316789-nb4437qs 35 29 . . . cord-316789-nb4437qs 36 1 The the DT cord-316789-nb4437qs 36 2 study study NN cord-316789-nb4437qs 36 3 with with IN cord-316789-nb4437qs 36 4 the the DT cord-316789-nb4437qs 36 5 use use NN cord-316789-nb4437qs 36 6 of of IN cord-316789-nb4437qs 36 7 the the DT cord-316789-nb4437qs 36 8 Drosophila Drosophila NNP cord-316789-nb4437qs 36 9 model model NN cord-316789-nb4437qs 36 10 made make VBD cord-316789-nb4437qs 36 11 it -PRON- PRP cord-316789-nb4437qs 36 12 clear clear JJ cord-316789-nb4437qs 36 13 that that IN cord-316789-nb4437qs 36 14 in in IN cord-316789-nb4437qs 36 15 addition addition NN cord-316789-nb4437qs 36 16 to to IN cord-316789-nb4437qs 36 17 this this DT cord-316789-nb4437qs 36 18 function function NN cord-316789-nb4437qs 36 19 the the DT cord-316789-nb4437qs 36 20 protein protein NN cord-316789-nb4437qs 36 21 is be VBZ cord-316789-nb4437qs 36 22 also also RB cord-316789-nb4437qs 36 23 able able JJ cord-316789-nb4437qs 36 24 to to TO cord-316789-nb4437qs 36 25 change change VB cord-316789-nb4437qs 36 26 the the DT cord-316789-nb4437qs 36 27 cell cell NN cord-316789-nb4437qs 36 28 structure structure NN cord-316789-nb4437qs 36 29 . . . cord-316789-nb4437qs 37 1 To to TO cord-316789-nb4437qs 37 2 study study VB cord-316789-nb4437qs 37 3 the the DT cord-316789-nb4437qs 37 4 role role NN cord-316789-nb4437qs 37 5 of of IN cord-316789-nb4437qs 37 6 the the DT cord-316789-nb4437qs 37 7 HIV HIV NNP cord-316789-nb4437qs 37 8 nef nef NNP cord-316789-nb4437qs 37 9 gene gene NN cord-316789-nb4437qs 37 10 in in IN cord-316789-nb4437qs 37 11 HIV HIV NNP cord-316789-nb4437qs 37 12 infec infec IN cord-316789-nb4437qs 37 13 tion tion NN cord-316789-nb4437qs 37 14 , , , cord-316789-nb4437qs 37 15 Lee Lee NNP cord-316789-nb4437qs 37 16 et et NNP cord-316789-nb4437qs 37 17 al al NNP cord-316789-nb4437qs 37 18 . . . cord-316789-nb4437qs 38 1 [ [ -LRB- cord-316789-nb4437qs 38 2 21 21 CD cord-316789-nb4437qs 38 3 ] ] -RRB- cord-316789-nb4437qs 38 4 cloned clone VBN cord-316789-nb4437qs 38 5 DNA dna NN cord-316789-nb4437qs 38 6 of of IN cord-316789-nb4437qs 38 7 this this DT cord-316789-nb4437qs 38 8 gene gene NN cord-316789-nb4437qs 38 9 and and CC cord-316789-nb4437qs 38 10 DNA dna NN cord-316789-nb4437qs 38 11 of of IN cord-316789-nb4437qs 38 12 its -PRON- PRP$ cord-316789-nb4437qs 38 13 mutant mutant JJ cord-316789-nb4437qs 38 14 form form NN cord-316789-nb4437qs 38 15 ( ( -LRB- cord-316789-nb4437qs 38 16 G2A G2A NNP cord-316789-nb4437qs 38 17 substitution substitution NN cord-316789-nb4437qs 38 18 altering alter VBG cord-316789-nb4437qs 38 19 the the DT cord-316789-nb4437qs 38 20 myris myris NNP cord-316789-nb4437qs 38 21 tolation tolation NNP cord-316789-nb4437qs 38 22 site site NN cord-316789-nb4437qs 38 23 of of IN cord-316789-nb4437qs 38 24 the the DT cord-316789-nb4437qs 38 25 protein protein NN cord-316789-nb4437qs 38 26 ) ) -RRB- cord-316789-nb4437qs 38 27 into into IN cord-316789-nb4437qs 38 28 the the DT cord-316789-nb4437qs 38 29 pUAST puast NN cord-316789-nb4437qs 38 30 vector vector NN cord-316789-nb4437qs 38 31 and and CC cord-316789-nb4437qs 38 32 activated activate VBD cord-316789-nb4437qs 38 33 the the DT cord-316789-nb4437qs 38 34 transgene transgene NN cord-316789-nb4437qs 38 35 with with IN cord-316789-nb4437qs 38 36 the the DT cord-316789-nb4437qs 38 37 use use NN cord-316789-nb4437qs 38 38 of of IN cord-316789-nb4437qs 38 39 drivers driver NNS cord-316789-nb4437qs 38 40 1096 1096 CD cord-316789-nb4437qs 38 41 Gal4 Gal4 NNP cord-316789-nb4437qs 38 42 and and CC cord-316789-nb4437qs 38 43 ap ap NNP cord-316789-nb4437qs 38 44 Gal4 Gal4 NNP cord-316789-nb4437qs 38 45 in in IN cord-316789-nb4437qs 38 46 wing wing NN cord-316789-nb4437qs 38 47 imaginal imaginal JJ cord-316789-nb4437qs 38 48 discs disc NNS cord-316789-nb4437qs 38 49 . . . cord-316789-nb4437qs 39 1 Expression expression NN cord-316789-nb4437qs 39 2 of of IN cord-316789-nb4437qs 39 3 the the DT cord-316789-nb4437qs 39 4 wild wild JJ cord-316789-nb4437qs 39 5 type type NN cord-316789-nb4437qs 39 6 gene gene NN cord-316789-nb4437qs 39 7 led lead VBN cord-316789-nb4437qs 39 8 to to IN cord-316789-nb4437qs 39 9 abnormalities abnormality NNS cord-316789-nb4437qs 39 10 in in IN cord-316789-nb4437qs 39 11 the the DT cord-316789-nb4437qs 39 12 wing wing NN cord-316789-nb4437qs 39 13 shape shape NN cord-316789-nb4437qs 39 14 , , , cord-316789-nb4437qs 39 15 while while IN cord-316789-nb4437qs 39 16 no no DT cord-316789-nb4437qs 39 17 abnormalities abnormality NNS cord-316789-nb4437qs 39 18 were be VBD cord-316789-nb4437qs 39 19 observed observe VBN cord-316789-nb4437qs 39 20 in in IN cord-316789-nb4437qs 39 21 the the DT cord-316789-nb4437qs 39 22 mutant mutant NN cord-316789-nb4437qs 39 23 . . . cord-316789-nb4437qs 40 1 Using use VBG cord-316789-nb4437qs 40 2 BrdU BrdU NNP cord-316789-nb4437qs 40 3 incorporation incorporation NN cord-316789-nb4437qs 40 4 and and CC cord-316789-nb4437qs 40 5 detection detection NN cord-316789-nb4437qs 40 6 of of IN cord-316789-nb4437qs 40 7 mitoses mitose NNS cord-316789-nb4437qs 40 8 with with IN cord-316789-nb4437qs 40 9 the the DT cord-316789-nb4437qs 40 10 help help NN cord-316789-nb4437qs 40 11 of of IN cord-316789-nb4437qs 40 12 antibodies antibody NNS cord-316789-nb4437qs 40 13 against against IN cord-316789-nb4437qs 40 14 the the DT cord-316789-nb4437qs 40 15 phosphorylated phosphorylated JJ cord-316789-nb4437qs 40 16 H3 H3 NNP cord-316789-nb4437qs 40 17 his -PRON- PRP$ cord-316789-nb4437qs 40 18 tone tone NN cord-316789-nb4437qs 40 19 form form NN cord-316789-nb4437qs 40 20 , , , cord-316789-nb4437qs 40 21 it -PRON- PRP cord-316789-nb4437qs 40 22 was be VBD cord-316789-nb4437qs 40 23 found find VBN cord-316789-nb4437qs 40 24 that that IN cord-316789-nb4437qs 40 25 ectopic ectopic JJ cord-316789-nb4437qs 40 26 expression expression NN cord-316789-nb4437qs 40 27 of of IN cord-316789-nb4437qs 40 28 HIV HIV NNP cord-316789-nb4437qs 40 29 nef nef NNP cord-316789-nb4437qs 40 30 itself -PRON- PRP cord-316789-nb4437qs 40 31 and and CC cord-316789-nb4437qs 40 32 its -PRON- PRP$ cord-316789-nb4437qs 40 33 mutant mutant JJ cord-316789-nb4437qs 40 34 form form NN cord-316789-nb4437qs 40 35 had have VBD cord-316789-nb4437qs 40 36 no no DT cord-316789-nb4437qs 40 37 influence influence NN cord-316789-nb4437qs 40 38 on on IN cord-316789-nb4437qs 40 39 wing wing NN cord-316789-nb4437qs 40 40 cell cell NN cord-316789-nb4437qs 40 41 proliferation proliferation NN cord-316789-nb4437qs 40 42 . . . cord-316789-nb4437qs 41 1 Yet yet RB cord-316789-nb4437qs 41 2 , , , cord-316789-nb4437qs 41 3 ectopic ectopic JJ cord-316789-nb4437qs 41 4 expression expression NN cord-316789-nb4437qs 41 5 increased increase VBD cord-316789-nb4437qs 41 6 the the DT cord-316789-nb4437qs 41 7 level level NN cord-316789-nb4437qs 41 8 of of IN cord-316789-nb4437qs 41 9 apoptosis apoptosis NN cord-316789-nb4437qs 41 10 , , , cord-316789-nb4437qs 41 11 which which WDT cord-316789-nb4437qs 41 12 was be VBD cord-316789-nb4437qs 41 13 seen see VBN cord-316789-nb4437qs 41 14 with with IN cord-316789-nb4437qs 41 15 the the DT cord-316789-nb4437qs 41 16 use use NN cord-316789-nb4437qs 41 17 of of IN cord-316789-nb4437qs 41 18 both both DT cord-316789-nb4437qs 41 19 acridinorange acridinorange NN cord-316789-nb4437qs 41 20 detection detection NN cord-316789-nb4437qs 41 21 and and CC cord-316789-nb4437qs 41 22 antibodies antibody NNS cord-316789-nb4437qs 41 23 against against IN cord-316789-nb4437qs 41 24 Drosophila Drosophila NNP cord-316789-nb4437qs 41 25 Drice Drice NNP cord-316789-nb4437qs 41 26 caspase caspase NN cord-316789-nb4437qs 41 27 . . . cord-316789-nb4437qs 42 1 The the DT cord-316789-nb4437qs 42 2 authors author NNS cord-316789-nb4437qs 42 3 found find VBD cord-316789-nb4437qs 42 4 that that IN cord-316789-nb4437qs 42 5 genes gene NNS cord-316789-nb4437qs 42 6 involved involve VBN cord-316789-nb4437qs 42 7 in in IN cord-316789-nb4437qs 42 8 the the DT cord-316789-nb4437qs 42 9 JNK JNK NNP cord-316789-nb4437qs 42 10 ( ( -LRB- cord-316789-nb4437qs 42 11 June June NNP cord-316789-nb4437qs 42 12 N N NNP cord-316789-nb4437qs 42 13 terminal terminal NN cord-316789-nb4437qs 42 14 kinase kinase NN cord-316789-nb4437qs 42 15 ) ) -RRB- cord-316789-nb4437qs 42 16 signaling signal VBG cord-316789-nb4437qs 42 17 pathway pathway NN cord-316789-nb4437qs 42 18 ( ( -LRB- cord-316789-nb4437qs 42 19 bsk bsk NNP cord-316789-nb4437qs 42 20 , , , cord-316789-nb4437qs 42 21 hep hep NNP cord-316789-nb4437qs 42 22 ) ) -RRB- cord-316789-nb4437qs 42 23 genetically genetically RB cord-316789-nb4437qs 42 24 interact interact VBP cord-316789-nb4437qs 42 25 with with IN cord-316789-nb4437qs 42 26 HIV HIV NNP cord-316789-nb4437qs 42 27 nef nef NNP cord-316789-nb4437qs 42 28 ( ( -LRB- cord-316789-nb4437qs 42 29 both both DT cord-316789-nb4437qs 42 30 UAS UAS NNP cord-316789-nb4437qs 42 31 con con NN cord-316789-nb4437qs 42 32 structs struct NNS cord-316789-nb4437qs 42 33 and and CC cord-316789-nb4437qs 42 34 point point NN cord-316789-nb4437qs 42 35 mutations mutation NNS cord-316789-nb4437qs 42 36 ) ) -RRB- cord-316789-nb4437qs 42 37 under under IN cord-316789-nb4437qs 42 38 conditions condition NNS cord-316789-nb4437qs 42 39 of of IN cord-316789-nb4437qs 42 40 overex overex NNP cord-316789-nb4437qs 42 41 pression pression NNP cord-316789-nb4437qs 42 42 , , , cord-316789-nb4437qs 42 43 and and CC cord-316789-nb4437qs 42 44 the the DT cord-316789-nb4437qs 42 45 activity activity NN cord-316789-nb4437qs 42 46 of of IN cord-316789-nb4437qs 42 47 the the DT cord-316789-nb4437qs 42 48 puc puc NNP cord-316789-nb4437qs 42 49 gene gene NN cord-316789-nb4437qs 42 50 , , , cord-316789-nb4437qs 42 51 which which WDT cord-316789-nb4437qs 42 52 is be VBZ cord-316789-nb4437qs 42 53 a a DT cord-316789-nb4437qs 42 54 target target NN cord-316789-nb4437qs 42 55 for for IN cord-316789-nb4437qs 42 56 the the DT cord-316789-nb4437qs 42 57 action action NN cord-316789-nb4437qs 42 58 of of IN cord-316789-nb4437qs 42 59 bsk bsk NNP cord-316789-nb4437qs 42 60 , , , cord-316789-nb4437qs 42 61 is be VBZ cord-316789-nb4437qs 42 62 enhanced enhance VBN cord-316789-nb4437qs 42 63 in in IN cord-316789-nb4437qs 42 64 the the DT cord-316789-nb4437qs 42 65 presence presence NN cord-316789-nb4437qs 42 66 of of IN cord-316789-nb4437qs 42 67 an an DT cord-316789-nb4437qs 42 68 additional additional JJ cord-316789-nb4437qs 42 69 amount amount NN cord-316789-nb4437qs 42 70 of of IN cord-316789-nb4437qs 42 71 the the DT cord-316789-nb4437qs 42 72 HIV HIV NNP cord-316789-nb4437qs 42 73 nef nef NNP cord-316789-nb4437qs 42 74 gene gene NN cord-316789-nb4437qs 42 75 product product NN cord-316789-nb4437qs 42 76 . . . cord-316789-nb4437qs 43 1 Since since IN cord-316789-nb4437qs 43 2 the the DT cord-316789-nb4437qs 43 3 activity activity NN cord-316789-nb4437qs 43 4 of of IN cord-316789-nb4437qs 43 5 the the DT cord-316789-nb4437qs 43 6 JNK JNK NNP cord-316789-nb4437qs 43 7 signaling signal VBG cord-316789-nb4437qs 43 8 pathway pathway NN cord-316789-nb4437qs 43 9 in in IN cord-316789-nb4437qs 43 10 Drosophila Drosophila NNP cord-316789-nb4437qs 43 11 is be VBZ cord-316789-nb4437qs 43 12 characterized characterize VBN cord-316789-nb4437qs 43 13 by by IN cord-316789-nb4437qs 43 14 a a DT cord-316789-nb4437qs 43 15 complicated complicated JJ cord-316789-nb4437qs 43 16 spatial spatial JJ cord-316789-nb4437qs 43 17 regulation regulation NN cord-316789-nb4437qs 43 18 ( ( -LRB- cord-316789-nb4437qs 43 19 for for IN cord-316789-nb4437qs 43 20 example example NN cord-316789-nb4437qs 43 21 , , , cord-316789-nb4437qs 43 22 dorsal dorsal JJ cord-316789-nb4437qs 43 23 and and CC cord-316789-nb4437qs 43 24 thorax thorax NN cord-316789-nb4437qs 43 25 closures closure NNS cord-316789-nb4437qs 43 26 regulated regulate VBN cord-316789-nb4437qs 43 27 by by IN cord-316789-nb4437qs 43 28 JNK JNK NNP cord-316789-nb4437qs 43 29 are be VBP cord-316789-nb4437qs 43 30 complicated complicated JJ cord-316789-nb4437qs 43 31 events event NNS cord-316789-nb4437qs 43 32 of of IN cord-316789-nb4437qs 43 33 morphologcal morphologcal JJ cord-316789-nb4437qs 43 34 alterations alteration NNS cord-316789-nb4437qs 43 35 of of IN cord-316789-nb4437qs 43 36 an an DT cord-316789-nb4437qs 43 37 embryo embryo NN cord-316789-nb4437qs 43 38 or or CC cord-316789-nb4437qs 43 39 a a DT cord-316789-nb4437qs 43 40 growing grow VBG cord-316789-nb4437qs 43 41 pupa pupa NN cord-316789-nb4437qs 43 42 ) ) -RRB- cord-316789-nb4437qs 43 43 , , , cord-316789-nb4437qs 43 44 the the DT cord-316789-nb4437qs 43 45 authors author NNS cord-316789-nb4437qs 43 46 also also RB cord-316789-nb4437qs 43 47 checked check VBD cord-316789-nb4437qs 43 48 cel cel NNP cord-316789-nb4437qs 43 49 lular lular NNP cord-316789-nb4437qs 43 50 autonomy autonomy NN cord-316789-nb4437qs 43 51 of of IN cord-316789-nb4437qs 43 52 the the DT cord-316789-nb4437qs 43 53 action action NN cord-316789-nb4437qs 43 54 of of IN cord-316789-nb4437qs 43 55 HIV HIV NNP cord-316789-nb4437qs 43 56 nef nef NNP cord-316789-nb4437qs 43 57 with with IN cord-316789-nb4437qs 43 58 the the DT cord-316789-nb4437qs 43 59 help help NN cord-316789-nb4437qs 43 60 of of IN cord-316789-nb4437qs 43 61 the the DT cord-316789-nb4437qs 43 62 mosaic mosaic JJ cord-316789-nb4437qs 43 63 analysis analysis NN cord-316789-nb4437qs 43 64 . . . cord-316789-nb4437qs 44 1 Then then RB cord-316789-nb4437qs 44 2 the the DT cord-316789-nb4437qs 44 3 authors author NNS cord-316789-nb4437qs 44 4 established establish VBD cord-316789-nb4437qs 44 5 that that IN cord-316789-nb4437qs 44 6 HIV HIV NNP cord-316789-nb4437qs 44 7 nef nef NNP cord-316789-nb4437qs 44 8 , , , cord-316789-nb4437qs 44 9 but but CC cord-316789-nb4437qs 44 10 not not RB cord-316789-nb4437qs 44 11 its -PRON- PRP$ cord-316789-nb4437qs 44 12 mutant mutant JJ cord-316789-nb4437qs 44 13 form form NN cord-316789-nb4437qs 44 14 , , , cord-316789-nb4437qs 44 15 inhibits inhibit VBZ cord-316789-nb4437qs 44 16 expression expression NN cord-316789-nb4437qs 44 17 of of IN cord-316789-nb4437qs 44 18 the the DT cord-316789-nb4437qs 44 19 antimicrobial antimicrobial JJ cord-316789-nb4437qs 44 20 peptide peptide NN cord-316789-nb4437qs 44 21 Dpt Dpt NNP cord-316789-nb4437qs 44 22 of of IN cord-316789-nb4437qs 44 23 Drosophila Drosophila NNP cord-316789-nb4437qs 44 24 . . . cord-316789-nb4437qs 45 1 The the DT cord-316789-nb4437qs 45 2 protein protein NN cord-316789-nb4437qs 45 3 Relish relish NN cord-316789-nb4437qs 45 4 ( ( -LRB- cord-316789-nb4437qs 45 5 transcription transcription NN cord-316789-nb4437qs 45 6 factor factor NN cord-316789-nb4437qs 45 7 NF NF NNP cord-316789-nb4437qs 45 8 kB kB NNP cord-316789-nb4437qs 45 9 ) ) -RRB- cord-316789-nb4437qs 45 10 of of IN cord-316789-nb4437qs 45 11 Drosophila Drosophila NNP cord-316789-nb4437qs 45 12 , , , cord-316789-nb4437qs 45 13 which which WDT cord-316789-nb4437qs 45 14 controls control VBZ cord-316789-nb4437qs 45 15 Dpt Dpt NNP cord-316789-nb4437qs 45 16 transcription transcription NN cord-316789-nb4437qs 45 17 , , , cord-316789-nb4437qs 45 18 is be VBZ cord-316789-nb4437qs 45 19 translocated translocate VBN cord-316789-nb4437qs 45 20 from from IN cord-316789-nb4437qs 45 21 the the DT cord-316789-nb4437qs 45 22 cyto cyto NN cord-316789-nb4437qs 45 23 plasm plasm NN cord-316789-nb4437qs 45 24 into into IN cord-316789-nb4437qs 45 25 the the DT cord-316789-nb4437qs 45 26 nucleus nucleus NN cord-316789-nb4437qs 45 27 in in IN cord-316789-nb4437qs 45 28 the the DT cord-316789-nb4437qs 45 29 case case NN cord-316789-nb4437qs 45 30 of of IN cord-316789-nb4437qs 45 31 microbial microbial JJ cord-316789-nb4437qs 45 32 infections infection NNS cord-316789-nb4437qs 45 33 . . . cord-316789-nb4437qs 46 1 HIV HIV NNP cord-316789-nb4437qs 46 2 nef nef NNP cord-316789-nb4437qs 46 3 expression expression NN cord-316789-nb4437qs 46 4 inhibits inhibit VBZ cord-316789-nb4437qs 46 5 this this DT cord-316789-nb4437qs 46 6 change change NN cord-316789-nb4437qs 46 7 in in IN cord-316789-nb4437qs 46 8 the the DT cord-316789-nb4437qs 46 9 localization localization NN cord-316789-nb4437qs 46 10 of of IN cord-316789-nb4437qs 46 11 Relish relish NN cord-316789-nb4437qs 46 12 . . . cord-316789-nb4437qs 47 1 The the DT cord-316789-nb4437qs 47 2 authors author NNS cord-316789-nb4437qs 47 3 also also RB cord-316789-nb4437qs 47 4 studied study VBD cord-316789-nb4437qs 47 5 the the DT cord-316789-nb4437qs 47 6 question question NN cord-316789-nb4437qs 47 7 as as IN cord-316789-nb4437qs 47 8 to to IN cord-316789-nb4437qs 47 9 whether whether IN cord-316789-nb4437qs 47 10 inhibition inhibition NN cord-316789-nb4437qs 47 11 of of IN cord-316789-nb4437qs 47 12 Drosophila drosophila JJ cord-316789-nb4437qs 47 13 immunity immunity NN cord-316789-nb4437qs 47 14 is be VBZ cord-316789-nb4437qs 47 15 JNK JNK NNP cord-316789-nb4437qs 47 16 dependent dependent JJ cord-316789-nb4437qs 47 17 and and CC cord-316789-nb4437qs 47 18 showed show VBD cord-316789-nb4437qs 47 19 that that IN cord-316789-nb4437qs 47 20 the the DT cord-316789-nb4437qs 47 21 effects effect NNS cord-316789-nb4437qs 47 22 of of IN cord-316789-nb4437qs 47 23 HIV HIV NNP cord-316789-nb4437qs 47 24 nef nef NNP cord-316789-nb4437qs 47 25 on on IN cord-316789-nb4437qs 47 26 immunity immunity NN cord-316789-nb4437qs 47 27 and and CC cord-316789-nb4437qs 47 28 on on IN cord-316789-nb4437qs 47 29 JNK JNK NNP cord-316789-nb4437qs 47 30 are be VBP cord-316789-nb4437qs 47 31 independent independent JJ cord-316789-nb4437qs 47 32 of of IN cord-316789-nb4437qs 47 33 one one CD cord-316789-nb4437qs 47 34 another another DT cord-316789-nb4437qs 47 35 . . . cord-316789-nb4437qs 48 1 Thus thus RB cord-316789-nb4437qs 48 2 , , , cord-316789-nb4437qs 48 3 despite despite IN cord-316789-nb4437qs 48 4 a a DT cord-316789-nb4437qs 48 5 small small JJ cord-316789-nb4437qs 48 6 length length NN cord-316789-nb4437qs 48 7 ( ( -LRB- cord-316789-nb4437qs 48 8 206 206 CD cord-316789-nb4437qs 48 9 a.a a.a NNP cord-316789-nb4437qs 48 10 . . NNP cord-316789-nb4437qs 48 11 ) ) -RRB- cord-316789-nb4437qs 48 12 , , , cord-316789-nb4437qs 48 13 this this DT cord-316789-nb4437qs 48 14 viral viral JJ cord-316789-nb4437qs 48 15 protein protein NN cord-316789-nb4437qs 48 16 has have VBZ cord-316789-nb4437qs 48 17 two two CD cord-316789-nb4437qs 48 18 different different JJ cord-316789-nb4437qs 48 19 targets target NNS cord-316789-nb4437qs 48 20 in in IN cord-316789-nb4437qs 48 21 animal animal NN cord-316789-nb4437qs 48 22 cells cell NNS cord-316789-nb4437qs 48 23 . . . cord-316789-nb4437qs 49 1 Leulier Leulier NNP cord-316789-nb4437qs 49 2 et et NNP cord-316789-nb4437qs 49 3 al al NNP cord-316789-nb4437qs 49 4 . . . cord-316789-nb4437qs 50 1 [ [ -LRB- cord-316789-nb4437qs 50 2 22 22 CD cord-316789-nb4437qs 50 3 ] ] -RRB- cord-316789-nb4437qs 50 4 cloned clone VBN cord-316789-nb4437qs 50 5 cDNA cdna NN cord-316789-nb4437qs 50 6 of of IN cord-316789-nb4437qs 50 7 the the DT cord-316789-nb4437qs 50 8 HIV HIV NNP cord-316789-nb4437qs 50 9 vpu vpu NN cord-316789-nb4437qs 50 10 gene gene NN cord-316789-nb4437qs 50 11 and and CC cord-316789-nb4437qs 50 12 its -PRON- PRP$ cord-316789-nb4437qs 50 13 mutant mutant JJ cord-316789-nb4437qs 50 14 form form NN cord-316789-nb4437qs 50 15 ( ( -LRB- cord-316789-nb4437qs 50 16 Ser52 Ser52 NNP cord-316789-nb4437qs 50 17 and and CC cord-316789-nb4437qs 50 18 Ser56 Ser56 NNP cord-316789-nb4437qs 50 19 substituted substitute VBN cord-316789-nb4437qs 50 20 by by IN cord-316789-nb4437qs 50 21 Arg Arg NNP cord-316789-nb4437qs 50 22 ) ) -RRB- cord-316789-nb4437qs 50 23 , , , cord-316789-nb4437qs 50 24 which which WDT cord-316789-nb4437qs 50 25 does do VBZ cord-316789-nb4437qs 50 26 not not RB cord-316789-nb4437qs 50 27 permit permit VB cord-316789-nb4437qs 50 28 phosphorylation phosphorylation NN cord-316789-nb4437qs 50 29 of of IN cord-316789-nb4437qs 50 30 the the DT cord-316789-nb4437qs 50 31 product product NN cord-316789-nb4437qs 50 32 , , , cord-316789-nb4437qs 50 33 into into IN cord-316789-nb4437qs 50 34 the the DT cord-316789-nb4437qs 50 35 pUAST puast NN cord-316789-nb4437qs 50 36 vector vector NN cord-316789-nb4437qs 50 37 . . . cord-316789-nb4437qs 51 1 The the DT cord-316789-nb4437qs 51 2 transgene transgene NN cord-316789-nb4437qs 51 3 was be VBD cord-316789-nb4437qs 51 4 expressed express VBN cord-316789-nb4437qs 51 5 with with IN cord-316789-nb4437qs 51 6 the the DT cord-316789-nb4437qs 51 7 use use NN cord-316789-nb4437qs 51 8 of of IN cord-316789-nb4437qs 51 9 the the DT cord-316789-nb4437qs 51 10 yolk yolk NN cord-316789-nb4437qs 51 11 GAL4 GAL4 NNP cord-316789-nb4437qs 51 12 driver driver NN cord-316789-nb4437qs 51 13 activating activate VBG cord-316789-nb4437qs 51 14 expression expression NN cord-316789-nb4437qs 51 15 in in IN cord-316789-nb4437qs 51 16 the the DT cord-316789-nb4437qs 51 17 fat fat JJ cord-316789-nb4437qs 51 18 body body NN cord-316789-nb4437qs 51 19 . . . cord-316789-nb4437qs 52 1 In in IN cord-316789-nb4437qs 52 2 human human JJ cord-316789-nb4437qs 52 3 cells cell NNS cord-316789-nb4437qs 52 4 , , , cord-316789-nb4437qs 52 5 HIV HIV NNP cord-316789-nb4437qs 52 6 vpu vpu NN cord-316789-nb4437qs 52 7 is be VBZ cord-316789-nb4437qs 52 8 found find VBN cord-316789-nb4437qs 52 9 in in IN cord-316789-nb4437qs 52 10 the the DT cord-316789-nb4437qs 52 11 phosphorylated phosphorylated JJ cord-316789-nb4437qs 52 12 and and CC cord-316789-nb4437qs 52 13 nonphosphorylated nonphosphorylated JJ cord-316789-nb4437qs 52 14 forms form NNS cord-316789-nb4437qs 52 15 . . . cord-316789-nb4437qs 53 1 After after IN cord-316789-nb4437qs 53 2 treatment treatment NN cord-316789-nb4437qs 53 3 with with IN cord-316789-nb4437qs 53 4 alkaline alkaline JJ cord-316789-nb4437qs 53 5 phosphatase phosphatase NN cord-316789-nb4437qs 53 6 , , , cord-316789-nb4437qs 53 7 the the DT cord-316789-nb4437qs 53 8 difference difference NN cord-316789-nb4437qs 53 9 in in IN cord-316789-nb4437qs 53 10 the the DT cord-316789-nb4437qs 53 11 mobility mobility NN cord-316789-nb4437qs 53 12 of of IN cord-316789-nb4437qs 53 13 the the DT cord-316789-nb4437qs 53 14 proteins protein NNS cord-316789-nb4437qs 53 15 disappears disappear VBZ cord-316789-nb4437qs 53 16 . . . cord-316789-nb4437qs 54 1 The the DT cord-316789-nb4437qs 54 2 authors author NNS cord-316789-nb4437qs 54 3 showed show VBD cord-316789-nb4437qs 54 4 that that IN cord-316789-nb4437qs 54 5 in in IN cord-316789-nb4437qs 54 6 Drosophila Drosophila NNP cord-316789-nb4437qs 54 7 cells cell NNS cord-316789-nb4437qs 54 8 the the DT cord-316789-nb4437qs 54 9 protein protein NN cord-316789-nb4437qs 54 10 behaves behave VBZ cord-316789-nb4437qs 54 11 analogously analogously RB cord-316789-nb4437qs 54 12 , , , cord-316789-nb4437qs 54 13 i. i. NNP cord-316789-nb4437qs 54 14 e. e. NNP cord-316789-nb4437qs 54 15 , , , cord-316789-nb4437qs 54 16 it -PRON- PRP cord-316789-nb4437qs 54 17 can can MD cord-316789-nb4437qs 54 18 be be VB cord-316789-nb4437qs 54 19 phosphorylated phosphorylate VBN cord-316789-nb4437qs 54 20 . . . cord-316789-nb4437qs 55 1 This this DT cord-316789-nb4437qs 55 2 fact fact NN cord-316789-nb4437qs 55 3 by by IN cord-316789-nb4437qs 55 4 itself -PRON- PRP cord-316789-nb4437qs 55 5 is be VBZ cord-316789-nb4437qs 55 6 a a DT cord-316789-nb4437qs 55 7 strong strong JJ cord-316789-nb4437qs 55 8 argument argument NN cord-316789-nb4437qs 55 9 in in IN cord-316789-nb4437qs 55 10 favor favor NN cord-316789-nb4437qs 55 11 of of IN cord-316789-nb4437qs 55 12 using use VBG cord-316789-nb4437qs 55 13 Droso Droso NNP cord-316789-nb4437qs 55 14 phila phila NNP cord-316789-nb4437qs 55 15 as as IN cord-316789-nb4437qs 55 16 a a DT cord-316789-nb4437qs 55 17 model model NN cord-316789-nb4437qs 55 18 object object NN cord-316789-nb4437qs 55 19 for for IN cord-316789-nb4437qs 55 20 studying study VBG cord-316789-nb4437qs 55 21 viral viral JJ cord-316789-nb4437qs 55 22 infections infection NNS cord-316789-nb4437qs 55 23 . . . cord-316789-nb4437qs 56 1 In in IN cord-316789-nb4437qs 56 2 Drosophila Drosophila NNP cord-316789-nb4437qs 56 3 , , , cord-316789-nb4437qs 56 4 responsible responsible JJ cord-316789-nb4437qs 56 5 for for IN cord-316789-nb4437qs 56 6 resistance resistance NN cord-316789-nb4437qs 56 7 to to IN cord-316789-nb4437qs 56 8 fungal fungal JJ cord-316789-nb4437qs 56 9 infections infection NNS cord-316789-nb4437qs 56 10 is be VBZ cord-316789-nb4437qs 56 11 the the DT cord-316789-nb4437qs 56 12 Toll Toll NNP cord-316789-nb4437qs 56 13 signaling signal VBG cord-316789-nb4437qs 56 14 pathway pathway NN cord-316789-nb4437qs 56 15 controlling control VBG cord-316789-nb4437qs 56 16 expression expression NN cord-316789-nb4437qs 56 17 of of IN cord-316789-nb4437qs 56 18 the the DT cord-316789-nb4437qs 56 19 Drs Drs NNP cord-316789-nb4437qs 56 20 and and CC cord-316789-nb4437qs 56 21 Mtk Mtk NNP cord-316789-nb4437qs 56 22 peptides peptide NNS cord-316789-nb4437qs 56 23 [ [ -LRB- cord-316789-nb4437qs 56 24 23 23 CD cord-316789-nb4437qs 56 25 ] ] -RRB- cord-316789-nb4437qs 56 26 . . . cord-316789-nb4437qs 57 1 Induction induction NN cord-316789-nb4437qs 57 2 of of IN cord-316789-nb4437qs 57 3 these these DT cord-316789-nb4437qs 57 4 peptides peptide NNS cord-316789-nb4437qs 57 5 is be VBZ cord-316789-nb4437qs 57 6 essentially essentially RB cord-316789-nb4437qs 57 7 disturbed disturb VBN cord-316789-nb4437qs 57 8 in in IN cord-316789-nb4437qs 57 9 individuals individual NNS cord-316789-nb4437qs 57 10 with with IN cord-316789-nb4437qs 57 11 HIV HIV NNP cord-316789-nb4437qs 57 12 vpu vpu NNP cord-316789-nb4437qs 57 13 expres expres NNP cord-316789-nb4437qs 57 14 sion sion NNP cord-316789-nb4437qs 57 15 , , , cord-316789-nb4437qs 57 16 but but CC cord-316789-nb4437qs 57 17 is be VBZ cord-316789-nb4437qs 57 18 not not RB cord-316789-nb4437qs 57 19 disturbed disturb VBN cord-316789-nb4437qs 57 20 in in IN cord-316789-nb4437qs 57 21 the the DT cord-316789-nb4437qs 57 22 nonphosphorylatable nonphosphorylatable JJ cord-316789-nb4437qs 57 23 mutant mutant NN cord-316789-nb4437qs 57 24 . . . cord-316789-nb4437qs 58 1 In in IN cord-316789-nb4437qs 58 2 support support NN cord-316789-nb4437qs 58 3 of of IN cord-316789-nb4437qs 58 4 this this DT cord-316789-nb4437qs 58 5 , , , cord-316789-nb4437qs 58 6 the the DT cord-316789-nb4437qs 58 7 authors author NNS cord-316789-nb4437qs 58 8 showed show VBD cord-316789-nb4437qs 58 9 that that IN cord-316789-nb4437qs 58 10 the the DT cord-316789-nb4437qs 58 11 dominant dominant JJ cord-316789-nb4437qs 58 12 Tl Tl NNP cord-316789-nb4437qs 58 13 10B 10B NNP cord-316789-nb4437qs 58 14 mutation mutation NN cord-316789-nb4437qs 58 15 of of IN cord-316789-nb4437qs 58 16 the the DT cord-316789-nb4437qs 58 17 Toll Toll NNP cord-316789-nb4437qs 58 18 signaling signal VBG cord-316789-nb4437qs 58 19 pathway pathway NN cord-316789-nb4437qs 58 20 , , , cord-316789-nb4437qs 58 21 which which WDT cord-316789-nb4437qs 58 22 causes cause VBZ cord-316789-nb4437qs 58 23 connstitutive connstitutive NNP cord-316789-nb4437qs 58 24 activation activation NN cord-316789-nb4437qs 58 25 of of IN cord-316789-nb4437qs 58 26 Drs Drs NNP cord-316789-nb4437qs 58 27 and and CC cord-316789-nb4437qs 58 28 Mtk Mtk NNP cord-316789-nb4437qs 58 29 , , , cord-316789-nb4437qs 58 30 does do VBZ cord-316789-nb4437qs 58 31 not not RB cord-316789-nb4437qs 58 32 produce produce VB cord-316789-nb4437qs 58 33 this this DT cord-316789-nb4437qs 58 34 effect effect NN cord-316789-nb4437qs 58 35 against against IN cord-316789-nb4437qs 58 36 the the DT cord-316789-nb4437qs 58 37 background background NN cord-316789-nb4437qs 58 38 of of IN cord-316789-nb4437qs 58 39 Vpu Vpu NNP cord-316789-nb4437qs 58 40 overexpression overexpression NN cord-316789-nb4437qs 58 41 . . . cord-316789-nb4437qs 59 1 At at IN cord-316789-nb4437qs 59 2 the the DT cord-316789-nb4437qs 59 3 same same JJ cord-316789-nb4437qs 59 4 time time NN cord-316789-nb4437qs 59 5 , , , cord-316789-nb4437qs 59 6 the the DT cord-316789-nb4437qs 59 7 authors author NNS cord-316789-nb4437qs 59 8 found find VBD cord-316789-nb4437qs 59 9 that that IN cord-316789-nb4437qs 59 10 the the DT cord-316789-nb4437qs 59 11 resistance resistance NN cord-316789-nb4437qs 59 12 to to TO cord-316789-nb4437qs 59 13 gram gram VB cord-316789-nb4437qs 59 14 positive positive JJ cord-316789-nb4437qs 59 15 bacteria bacteria NNS cord-316789-nb4437qs 59 16 associated associate VBN cord-316789-nb4437qs 59 17 with with IN cord-316789-nb4437qs 59 18 the the DT cord-316789-nb4437qs 59 19 Imd Imd NNP cord-316789-nb4437qs 59 20 signaling signal VBG cord-316789-nb4437qs 59 21 activity activity NN cord-316789-nb4437qs 59 22 does do VBZ cord-316789-nb4437qs 59 23 not not RB cord-316789-nb4437qs 59 24 change change VB cord-316789-nb4437qs 59 25 in in IN cord-316789-nb4437qs 59 26 the the DT cord-316789-nb4437qs 59 27 case case NN cord-316789-nb4437qs 59 28 of of IN cord-316789-nb4437qs 59 29 HIV HIV NNP cord-316789-nb4437qs 59 30 vpu vpu NN cord-316789-nb4437qs 59 31 overexpression overexpression NN cord-316789-nb4437qs 59 32 . . . cord-316789-nb4437qs 60 1 The the DT cord-316789-nb4437qs 60 2 data datum NNS cord-316789-nb4437qs 60 3 on on IN cord-316789-nb4437qs 60 4 the the DT cord-316789-nb4437qs 60 5 ability ability NN cord-316789-nb4437qs 60 6 of of IN cord-316789-nb4437qs 60 7 the the DT cord-316789-nb4437qs 60 8 Drosophila drosophila JJ cord-316789-nb4437qs 60 9 model model NN cord-316789-nb4437qs 60 10 to to TO cord-316789-nb4437qs 60 11 reveal reveal VB cord-316789-nb4437qs 60 12 new new JJ cord-316789-nb4437qs 60 13 aspects aspect NNS cord-316789-nb4437qs 60 14 of of IN cord-316789-nb4437qs 60 15 HIV HIV NNP cord-316789-nb4437qs 60 16 - - HYPH cord-316789-nb4437qs 60 17 host host NN cord-316789-nb4437qs 60 18 cells cell NNS cord-316789-nb4437qs 60 19 interactions interaction NNS cord-316789-nb4437qs 60 20 were be VBD cord-316789-nb4437qs 60 21 considered consider VBN cord-316789-nb4437qs 60 22 by by IN cord-316789-nb4437qs 60 23 Spresser Spresser NNP cord-316789-nb4437qs 60 24 and and CC cord-316789-nb4437qs 60 25 Carlson Carlson NNP cord-316789-nb4437qs 60 26 [ [ -LRB- cord-316789-nb4437qs 60 27 24 24 CD cord-316789-nb4437qs 60 28 ] ] -RRB- cord-316789-nb4437qs 60 29 . . . cord-316789-nb4437qs 61 1 The the DT cord-316789-nb4437qs 61 2 authors author NNS cord-316789-nb4437qs 61 3 proposed propose VBD cord-316789-nb4437qs 61 4 to to TO cord-316789-nb4437qs 61 5 study study VB cord-316789-nb4437qs 61 6 additionally additionally RB cord-316789-nb4437qs 61 7 genes gene NNS cord-316789-nb4437qs 61 8 CCR3 CCR3 NNP cord-316789-nb4437qs 61 9 , , , cord-316789-nb4437qs 61 10 Vpr Vpr NNP cord-316789-nb4437qs 61 11 , , , cord-316789-nb4437qs 61 12 CA150 CA150 NNP cord-316789-nb4437qs 61 13 , , , cord-316789-nb4437qs 61 14 Pol Pol NNP cord-316789-nb4437qs 61 15 gamma gamma NN cord-316789-nb4437qs 61 16 , , , cord-316789-nb4437qs 61 17 GL1 GL1 NNP cord-316789-nb4437qs 61 18 , , , cord-316789-nb4437qs 61 19 P p NN cord-316789-nb4437qs 61 20 TEFb TEFb NNS cord-316789-nb4437qs 61 21 , , , cord-316789-nb4437qs 61 22 and and CC cord-316789-nb4437qs 61 23 Spt Spt NNP cord-316789-nb4437qs 61 24 4 4 CD cord-316789-nb4437qs 61 25 , , , cord-316789-nb4437qs 61 26 5 5 CD cord-316789-nb4437qs 61 27 , , , cord-316789-nb4437qs 61 28 6 6 CD cord-316789-nb4437qs 61 29 , , , cord-316789-nb4437qs 61 30 since since IN cord-316789-nb4437qs 61 31 they -PRON- PRP cord-316789-nb4437qs 61 32 have have VBP cord-316789-nb4437qs 61 33 homologs homolog NNS cord-316789-nb4437qs 61 34 in in IN cord-316789-nb4437qs 61 35 the the DT cord-316789-nb4437qs 61 36 Drosophila Drosophila NNP cord-316789-nb4437qs 61 37 genome genome NN cord-316789-nb4437qs 61 38 and and CC cord-316789-nb4437qs 61 39 may may MD cord-316789-nb4437qs 61 40 well well RB cord-316789-nb4437qs 61 41 be be VB cord-316789-nb4437qs 61 42 of of IN cord-316789-nb4437qs 61 43 interest interest NN cord-316789-nb4437qs 61 44 for for IN cord-316789-nb4437qs 61 45 studying study VBG cord-316789-nb4437qs 61 46 HIV HIV NNP cord-316789-nb4437qs 61 47 infections infection NNS cord-316789-nb4437qs 61 48 . . . cord-316789-nb4437qs 62 1 Drosophila Drosophila NNP cord-316789-nb4437qs 62 2 was be VBD cord-316789-nb4437qs 62 3 also also RB cord-316789-nb4437qs 62 4 used use VBN cord-316789-nb4437qs 62 5 as as IN cord-316789-nb4437qs 62 6 a a DT cord-316789-nb4437qs 62 7 model model NN cord-316789-nb4437qs 62 8 object object NN cord-316789-nb4437qs 62 9 for for IN cord-316789-nb4437qs 62 10 studying study VBG cord-316789-nb4437qs 62 11 infections infection NNS cord-316789-nb4437qs 62 12 caused cause VBN cord-316789-nb4437qs 62 13 by by IN cord-316789-nb4437qs 62 14 other other JJ cord-316789-nb4437qs 62 15 viruses virus NNS cord-316789-nb4437qs 62 16 . . . cord-316789-nb4437qs 63 1 To to TO cord-316789-nb4437qs 63 2 study study VB cord-316789-nb4437qs 63 3 the the DT cord-316789-nb4437qs 63 4 functional functional JJ cord-316789-nb4437qs 63 5 role role NN cord-316789-nb4437qs 63 6 of of IN cord-316789-nb4437qs 63 7 the the DT cord-316789-nb4437qs 63 8 3a 3a NNP cord-316789-nb4437qs 63 9 gene gene NN cord-316789-nb4437qs 63 10 of of IN cord-316789-nb4437qs 63 11 the the DT cord-316789-nb4437qs 63 12 SARS SARS NNP cord-316789-nb4437qs 64 1 ( ( -LRB- cord-316789-nb4437qs 64 2 Severe severe JJ cord-316789-nb4437qs 64 3 Acute acute JJ cord-316789-nb4437qs 64 4 Respiratory Respiratory NNP cord-316789-nb4437qs 64 5 Syndrome Syndrome NNP cord-316789-nb4437qs 64 6 ) ) -RRB- cord-316789-nb4437qs 65 1 coronavirus coronavirus NN cord-316789-nb4437qs 65 2 encoding encode VBG cord-316789-nb4437qs 65 3 a a DT cord-316789-nb4437qs 65 4 274 274 CD cord-316789-nb4437qs 65 5 a.a a.a NNP cord-316789-nb4437qs 65 6 . . NNP cord-316789-nb4437qs 65 7 protein protein NN cord-316789-nb4437qs 65 8 ( ( -LRB- cord-316789-nb4437qs 65 9 expression expression NN cord-316789-nb4437qs 65 10 of of IN cord-316789-nb4437qs 65 11 the the DT cord-316789-nb4437qs 65 12 protein protein NN cord-316789-nb4437qs 66 1 was be VBD cord-316789-nb4437qs 66 2 con con NN cord-316789-nb4437qs 66 3 firmed firm VBN cord-316789-nb4437qs 66 4 for for IN cord-316789-nb4437qs 66 5 patients patient NNS cord-316789-nb4437qs 66 6 infected infect VBN cord-316789-nb4437qs 66 7 by by IN cord-316789-nb4437qs 66 8 this this DT cord-316789-nb4437qs 66 9 virus virus NN cord-316789-nb4437qs 66 10 ) ) -RRB- cord-316789-nb4437qs 66 11 , , , cord-316789-nb4437qs 66 12 a a DT cord-316789-nb4437qs 66 13 transgenic transgenic JJ cord-316789-nb4437qs 66 14 Drosophila Drosophila NNP cord-316789-nb4437qs 66 15 strain strain NN cord-316789-nb4437qs 66 16 containing contain VBG cord-316789-nb4437qs 66 17 a a DT cord-316789-nb4437qs 66 18 genomic genomic JJ cord-316789-nb4437qs 66 19 insertion insertion NN cord-316789-nb4437qs 66 20 of of IN cord-316789-nb4437qs 66 21 the the DT cord-316789-nb4437qs 66 22 gene gene NN cord-316789-nb4437qs 66 23 of of IN cord-316789-nb4437qs 66 24 this this DT cord-316789-nb4437qs 66 25 protein protein NN cord-316789-nb4437qs 66 26 in in IN cord-316789-nb4437qs 66 27 the the DT cord-316789-nb4437qs 66 28 pUAST puast NN cord-316789-nb4437qs 66 29 vector vector NN cord-316789-nb4437qs 67 1 was be VBD cord-316789-nb4437qs 67 2 gen gen NNP cord-316789-nb4437qs 67 3 erated erate VBN cord-316789-nb4437qs 67 4 in in IN cord-316789-nb4437qs 67 5 the the DT cord-316789-nb4437qs 67 6 work work NN cord-316789-nb4437qs 67 7 [ [ -LRB- cord-316789-nb4437qs 67 8 25 25 CD cord-316789-nb4437qs 67 9 ] ] -RRB- cord-316789-nb4437qs 67 10 . . . cord-316789-nb4437qs 68 1 Ectopic ectopic JJ cord-316789-nb4437qs 68 2 expression expression NN cord-316789-nb4437qs 68 3 of of IN cord-316789-nb4437qs 68 4 the the DT cord-316789-nb4437qs 68 5 3a 3a NNP cord-316789-nb4437qs 68 6 protein protein NN cord-316789-nb4437qs 68 7 in in IN cord-316789-nb4437qs 68 8 Drosophila Drosophila NNP cord-316789-nb4437qs 68 9 under under IN cord-316789-nb4437qs 68 10 the the DT cord-316789-nb4437qs 68 11 action action NN cord-316789-nb4437qs 68 12 of of IN cord-316789-nb4437qs 68 13 the the DT cord-316789-nb4437qs 68 14 eye eye NN cord-316789-nb4437qs 68 15 driver driver NN cord-316789-nb4437qs 68 16 GMR GMR NNP cord-316789-nb4437qs 68 17 Gal4 Gal4 NNP cord-316789-nb4437qs 68 18 caused cause VBD cord-316789-nb4437qs 68 19 the the DT cord-316789-nb4437qs 68 20 dominant dominant JJ cord-316789-nb4437qs 68 21 phenotype phenotype NN cord-316789-nb4437qs 68 22 of of IN cord-316789-nb4437qs 68 23 the the DT cord-316789-nb4437qs 68 24 eyes eye NNS cord-316789-nb4437qs 68 25 . . . cord-316789-nb4437qs 69 1 It -PRON- PRP cord-316789-nb4437qs 69 2 was be VBD cord-316789-nb4437qs 69 3 found find VBN cord-316789-nb4437qs 69 4 that that IN cord-316789-nb4437qs 69 5 ectopic ectopic JJ cord-316789-nb4437qs 69 6 expression expression NN cord-316789-nb4437qs 69 7 of of IN cord-316789-nb4437qs 69 8 3a 3a NNP cord-316789-nb4437qs 69 9 influ influ NNP cord-316789-nb4437qs 69 10 ences ence VBZ cord-316789-nb4437qs 69 11 the the DT cord-316789-nb4437qs 69 12 vesicular vesicular JJ cord-316789-nb4437qs 69 13 cell cell NN cord-316789-nb4437qs 69 14 traffic traffic NN cord-316789-nb4437qs 69 15 and and CC cord-316789-nb4437qs 69 16 induces induce VBZ cord-316789-nb4437qs 69 17 cell cell NN cord-316789-nb4437qs 69 18 apopto apopto NNP cord-316789-nb4437qs 70 1 sis sis NNP cord-316789-nb4437qs 71 1 that that DT cord-316789-nb4437qs 71 2 can can MD cord-316789-nb4437qs 71 3 be be VB cord-316789-nb4437qs 71 4 modulated modulate VBN cord-316789-nb4437qs 71 5 by by IN cord-316789-nb4437qs 71 6 the the DT cord-316789-nb4437qs 71 7 level level NN cord-316789-nb4437qs 71 8 of of IN cord-316789-nb4437qs 71 9 cellular cellular JJ cord-316789-nb4437qs 71 10 cyto cyto NN cord-316789-nb4437qs 71 11 chrome chrome NN cord-316789-nb4437qs 71 12 C C NNP cord-316789-nb4437qs 71 13 and and CC cord-316789-nb4437qs 71 14 by by IN cord-316789-nb4437qs 71 15 the the DT cord-316789-nb4437qs 71 16 activity activity NN cord-316789-nb4437qs 71 17 of of IN cord-316789-nb4437qs 71 18 caspases caspase NNS cord-316789-nb4437qs 71 19 destroying destroy VBG cord-316789-nb4437qs 71 20 cellular cellular JJ cord-316789-nb4437qs 71 21 structures structure NNS cord-316789-nb4437qs 71 22 during during IN cord-316789-nb4437qs 71 23 apoptosis apoptosis NN cord-316789-nb4437qs 71 24 . . . cord-316789-nb4437qs 72 1 As as IN cord-316789-nb4437qs 72 2 shown show VBN cord-316789-nb4437qs 72 3 by by IN cord-316789-nb4437qs 72 4 genetic genetic JJ cord-316789-nb4437qs 72 5 screening screening NN cord-316789-nb4437qs 72 6 , , , cord-316789-nb4437qs 72 7 the the DT cord-316789-nb4437qs 72 8 phenotype phenotype NN cord-316789-nb4437qs 72 9 resulting result VBG cord-316789-nb4437qs 72 10 from from IN cord-316789-nb4437qs 72 11 ectopic ectopic JJ cord-316789-nb4437qs 72 12 expression expression NN cord-316789-nb4437qs 72 13 is be VBZ cord-316789-nb4437qs 72 14 modified modify VBN cord-316789-nb4437qs 72 15 by by IN cord-316789-nb4437qs 72 16 heterozygous heterozygous JJ cord-316789-nb4437qs 72 17 muta muta NN cord-316789-nb4437qs 72 18 tions tion NNS cord-316789-nb4437qs 72 19 at at IN cord-316789-nb4437qs 72 20 78 78 CD cord-316789-nb4437qs 72 21 loci locus NNS cord-316789-nb4437qs 72 22 of of IN cord-316789-nb4437qs 72 23 Drosophila Drosophila NNP cord-316789-nb4437qs 72 24 . . . cord-316789-nb4437qs 73 1 Thus thus RB cord-316789-nb4437qs 73 2 , , , cord-316789-nb4437qs 73 3 the the DT cord-316789-nb4437qs 73 4 use use NN cord-316789-nb4437qs 73 5 of of IN cord-316789-nb4437qs 73 6 trans trans NNP cord-316789-nb4437qs 73 7 genic genic NNP cord-316789-nb4437qs 73 8 Drosophila Drosophila NNP cord-316789-nb4437qs 73 9 individuals individual NNS cord-316789-nb4437qs 73 10 was be VBD cord-316789-nb4437qs 73 11 proved prove VBN cord-316789-nb4437qs 73 12 to to TO cord-316789-nb4437qs 73 13 be be VB cord-316789-nb4437qs 73 14 efficient efficient JJ cord-316789-nb4437qs 73 15 for for IN cord-316789-nb4437qs 73 16 studying study VBG cord-316789-nb4437qs 73 17 the the DT cord-316789-nb4437qs 73 18 function function NN cord-316789-nb4437qs 73 19 of of IN cord-316789-nb4437qs 73 20 viral viral JJ cord-316789-nb4437qs 73 21 genes gene NNS cord-316789-nb4437qs 73 22 . . . cord-316789-nb4437qs 74 1 The the DT cord-316789-nb4437qs 74 2 Epstein Epstein NNP cord-316789-nb4437qs 74 3 - - HYPH cord-316789-nb4437qs 74 4 Barr Barr NNP cord-316789-nb4437qs 74 5 virus virus NN cord-316789-nb4437qs 74 6 causes cause VBZ cord-316789-nb4437qs 74 7 infectious infectious JJ cord-316789-nb4437qs 74 8 mononu mononu NN cord-316789-nb4437qs 74 9 cleosis cleosis NN cord-316789-nb4437qs 74 10 , , , cord-316789-nb4437qs 74 11 lymphomas lymphoma NNS cord-316789-nb4437qs 74 12 , , , cord-316789-nb4437qs 74 13 and and CC cord-316789-nb4437qs 74 14 nasopharyngeal nasopharyngeal JJ cord-316789-nb4437qs 74 15 carcinoma carcinoma NN cord-316789-nb4437qs 74 16 . . . cord-316789-nb4437qs 75 1 The the DT cord-316789-nb4437qs 75 2 BZLF1 bzlf1 JJ cord-316789-nb4437qs 75 3 protein protein NN cord-316789-nb4437qs 75 4 functions function NNS cord-316789-nb4437qs 75 5 as as IN cord-316789-nb4437qs 75 6 a a DT cord-316789-nb4437qs 75 7 transcriptional transcriptional JJ cord-316789-nb4437qs 75 8 acti acti NNP cord-316789-nb4437qs 75 9 vator vator NN cord-316789-nb4437qs 75 10 of of IN cord-316789-nb4437qs 75 11 expression expression NN cord-316789-nb4437qs 75 12 of of IN cord-316789-nb4437qs 75 13 early early JJ cord-316789-nb4437qs 75 14 genes gene NNS cord-316789-nb4437qs 75 15 of of IN cord-316789-nb4437qs 75 16 the the DT cord-316789-nb4437qs 75 17 virus virus NN cord-316789-nb4437qs 75 18 and and CC cord-316789-nb4437qs 75 19 con con NN cord-316789-nb4437qs 75 20 trols trol VBZ cord-316789-nb4437qs 75 21 the the DT cord-316789-nb4437qs 75 22 transition transition NN cord-316789-nb4437qs 75 23 from from IN cord-316789-nb4437qs 75 24 the the DT cord-316789-nb4437qs 75 25 latent latent JJ cord-316789-nb4437qs 75 26 form form NN cord-316789-nb4437qs 75 27 to to IN cord-316789-nb4437qs 75 28 the the DT cord-316789-nb4437qs 75 29 lytic lytic JJ cord-316789-nb4437qs 75 30 form form NN cord-316789-nb4437qs 75 31 . . . cord-316789-nb4437qs 76 1 BZLF1 BZLF1 NNP cord-316789-nb4437qs 76 2 also also RB cord-316789-nb4437qs 76 3 interferes interfere VBZ cord-316789-nb4437qs 76 4 with with IN cord-316789-nb4437qs 76 5 the the DT cord-316789-nb4437qs 76 6 cell cell NN cord-316789-nb4437qs 76 7 cycle cycle NN cord-316789-nb4437qs 76 8 regula regula NN cord-316789-nb4437qs 76 9 tion tion NN cord-316789-nb4437qs 76 10 , , , cord-316789-nb4437qs 76 11 intercellular intercellular JJ cord-316789-nb4437qs 76 12 signaling signaling NN cord-316789-nb4437qs 76 13 , , , cord-316789-nb4437qs 76 14 and and CC cord-316789-nb4437qs 76 15 transcription transcription NN cord-316789-nb4437qs 76 16 . . . cord-316789-nb4437qs 77 1 To to TO cord-316789-nb4437qs 77 2 study study VB cord-316789-nb4437qs 77 3 the the DT cord-316789-nb4437qs 77 4 function function NN cord-316789-nb4437qs 77 5 of of IN cord-316789-nb4437qs 77 6 BZLF1 BZLF1 NNP cord-316789-nb4437qs 77 7 , , , cord-316789-nb4437qs 77 8 Adamson Adamson NNP cord-316789-nb4437qs 77 9 et et NNP cord-316789-nb4437qs 77 10 al al NNP cord-316789-nb4437qs 77 11 . . . cord-316789-nb4437qs 78 1 cloned clone VBN cord-316789-nb4437qs 78 2 cDNA cdna NN cord-316789-nb4437qs 78 3 of of IN cord-316789-nb4437qs 78 4 the the DT cord-316789-nb4437qs 78 5 gene gene NN cord-316789-nb4437qs 78 6 into into IN cord-316789-nb4437qs 78 7 the the DT cord-316789-nb4437qs 78 8 pGMR pgmr JJ cord-316789-nb4437qs 78 9 vector vector NN cord-316789-nb4437qs 78 10 [ [ -LRB- cord-316789-nb4437qs 78 11 26 26 CD cord-316789-nb4437qs 78 12 ] ] -RRB- cord-316789-nb4437qs 78 13 . . . cord-316789-nb4437qs 79 1 The the DT cord-316789-nb4437qs 79 2 authors author NNS cord-316789-nb4437qs 79 3 also also RB cord-316789-nb4437qs 79 4 cloned clone VBD cord-316789-nb4437qs 79 5 cDNA cdna NN cord-316789-nb4437qs 79 6 of of IN cord-316789-nb4437qs 79 7 the the DT cord-316789-nb4437qs 79 8 mutant mutant JJ cord-316789-nb4437qs 79 9 form form NN cord-316789-nb4437qs 79 10 of of IN cord-316789-nb4437qs 79 11 the the DT cord-316789-nb4437qs 79 12 A185L A185L NNP cord-316789-nb4437qs 79 13 gene gene NN cord-316789-nb4437qs 79 14 , , , cord-316789-nb4437qs 79 15 which which WDT cord-316789-nb4437qs 79 16 alters alter VBZ cord-316789-nb4437qs 79 17 the the DT cord-316789-nb4437qs 79 18 DNA dna NN cord-316789-nb4437qs 79 19 binding binding NN cord-316789-nb4437qs 79 20 domain domain NN cord-316789-nb4437qs 79 21 of of IN cord-316789-nb4437qs 79 22 BZLF1 bzlf1 NN cord-316789-nb4437qs 79 23 and and CC cord-316789-nb4437qs 79 24 leads lead VBZ cord-316789-nb4437qs 79 25 to to IN cord-316789-nb4437qs 79 26 an an DT cord-316789-nb4437qs 79 27 experimentally experimentally RB cord-316789-nb4437qs 79 28 recorded record VBN cord-316789-nb4437qs 79 29 bind bind NN cord-316789-nb4437qs 79 30 ing ing DT cord-316789-nb4437qs 79 31 defect defect NN cord-316789-nb4437qs 79 32 . . . cord-316789-nb4437qs 80 1 Several several JJ cord-316789-nb4437qs 80 2 insertions insertion NNS cord-316789-nb4437qs 80 3 differing differ VBG cord-316789-nb4437qs 80 4 in in IN cord-316789-nb4437qs 80 5 the the DT cord-316789-nb4437qs 80 6 level level NN cord-316789-nb4437qs 80 7 of of IN cord-316789-nb4437qs 80 8 expression expression NN cord-316789-nb4437qs 80 9 of of IN cord-316789-nb4437qs 80 10 GMR GMR NNP cord-316789-nb4437qs 80 11 BZLF1 BZLF1 NNP cord-316789-nb4437qs 80 12 and and CC cord-316789-nb4437qs 80 13 UAS UAS NNP cord-316789-nb4437qs 80 14 BZLF1 BZLF1 NNP cord-316789-nb4437qs 80 15 trans trans NNP cord-316789-nb4437qs 80 16 genes gene NNS cord-316789-nb4437qs 80 17 were be VBD cord-316789-nb4437qs 80 18 obtained obtain VBN cord-316789-nb4437qs 80 19 . . . cord-316789-nb4437qs 81 1 The the DT cord-316789-nb4437qs 81 2 authors author NNS cord-316789-nb4437qs 81 3 showed show VBD cord-316789-nb4437qs 81 4 that that IN cord-316789-nb4437qs 81 5 insertions insertion NNS cord-316789-nb4437qs 81 6 of of IN cord-316789-nb4437qs 81 7 the the DT cord-316789-nb4437qs 81 8 con con NN cord-316789-nb4437qs 81 9 structs struct NNS cord-316789-nb4437qs 81 10 obtained obtain VBN cord-316789-nb4437qs 81 11 into into IN cord-316789-nb4437qs 81 12 the the DT cord-316789-nb4437qs 81 13 Drosophila Drosophila NNP cord-316789-nb4437qs 81 14 genome genome NN cord-316789-nb4437qs 81 15 bring bring VBP cord-316789-nb4437qs 81 16 about about IN cord-316789-nb4437qs 81 17 morphological morphological JJ cord-316789-nb4437qs 81 18 defects defect NNS cord-316789-nb4437qs 81 19 in in IN cord-316789-nb4437qs 81 20 the the DT cord-316789-nb4437qs 81 21 Drosophila Drosophila NNP cord-316789-nb4437qs 81 22 eye eye NN cord-316789-nb4437qs 81 23 as as IN cord-316789-nb4437qs 81 24 a a DT cord-316789-nb4437qs 81 25 result result NN cord-316789-nb4437qs 81 26 of of IN cord-316789-nb4437qs 81 27 the the DT cord-316789-nb4437qs 81 28 disappearance disappearance NN cord-316789-nb4437qs 81 29 of of IN cord-316789-nb4437qs 81 30 ommatidia ommatidia NNP cord-316789-nb4437qs 81 31 . . . cord-316789-nb4437qs 82 1 Morpholog Morpholog NNP cord-316789-nb4437qs 82 2 ical ical JJ cord-316789-nb4437qs 82 3 defects defect NNS cord-316789-nb4437qs 82 4 of of IN cord-316789-nb4437qs 82 5 the the DT cord-316789-nb4437qs 82 6 eye eye NN cord-316789-nb4437qs 82 7 for for IN cord-316789-nb4437qs 82 8 normal normal JJ cord-316789-nb4437qs 82 9 and and CC cord-316789-nb4437qs 82 10 mutant mutant JJ cord-316789-nb4437qs 82 11 BZLF1 BZLF1 NNP cord-316789-nb4437qs 82 12 did do VBD cord-316789-nb4437qs 82 13 not not RB cord-316789-nb4437qs 82 14 differ differ VB cord-316789-nb4437qs 82 15 , , , cord-316789-nb4437qs 82 16 thus thus RB cord-316789-nb4437qs 82 17 confirming confirm VBG cord-316789-nb4437qs 82 18 that that IN cord-316789-nb4437qs 82 19 the the DT cord-316789-nb4437qs 82 20 viral viral JJ cord-316789-nb4437qs 82 21 protein protein NN cord-316789-nb4437qs 82 22 acts act VBZ cord-316789-nb4437qs 82 23 not not RB cord-316789-nb4437qs 82 24 through through IN cord-316789-nb4437qs 82 25 transcription transcription NN cord-316789-nb4437qs 82 26 regulation regulation NN cord-316789-nb4437qs 82 27 , , , cord-316789-nb4437qs 82 28 as as IN cord-316789-nb4437qs 82 29 was be VBD cord-316789-nb4437qs 82 30 expected expect VBN cord-316789-nb4437qs 82 31 from from IN cord-316789-nb4437qs 82 32 the the DT cord-316789-nb4437qs 82 33 molecular molecular JJ cord-316789-nb4437qs 82 34 function function NN cord-316789-nb4437qs 82 35 of of IN cord-316789-nb4437qs 82 36 the the DT cord-316789-nb4437qs 82 37 protein protein NN cord-316789-nb4437qs 82 38 , , , cord-316789-nb4437qs 82 39 but but CC cord-316789-nb4437qs 82 40 in in IN cord-316789-nb4437qs 82 41 some some DT cord-316789-nb4437qs 82 42 other other JJ cord-316789-nb4437qs 82 43 manner manner NN cord-316789-nb4437qs 82 44 [ [ -LRB- cord-316789-nb4437qs 82 45 26 26 CD cord-316789-nb4437qs 82 46 ] ] -RRB- cord-316789-nb4437qs 82 47 . . . cord-316789-nb4437qs 83 1 The the DT cord-316789-nb4437qs 83 2 study study NN cord-316789-nb4437qs 83 3 of of IN cord-316789-nb4437qs 83 4 cell cell NN cord-316789-nb4437qs 83 5 divi divi NNP cord-316789-nb4437qs 83 6 sions sion NNS cord-316789-nb4437qs 83 7 in in IN cord-316789-nb4437qs 83 8 transgenic transgenic JJ cord-316789-nb4437qs 83 9 individuals individual NNS cord-316789-nb4437qs 83 10 showed show VBD cord-316789-nb4437qs 83 11 a a DT cord-316789-nb4437qs 83 12 reduction reduction NN cord-316789-nb4437qs 83 13 in in IN cord-316789-nb4437qs 83 14 the the DT cord-316789-nb4437qs 83 15 number number NN cord-316789-nb4437qs 83 16 of of IN cord-316789-nb4437qs 83 17 dividing divide VBG cord-316789-nb4437qs 83 18 cells cell NNS cord-316789-nb4437qs 83 19 in in IN cord-316789-nb4437qs 83 20 the the DT cord-316789-nb4437qs 83 21 second second JJ cord-316789-nb4437qs 83 22 mitotic mitotic JJ cord-316789-nb4437qs 83 23 wave wave NN cord-316789-nb4437qs 83 24 in in IN cord-316789-nb4437qs 83 25 the the DT cord-316789-nb4437qs 83 26 eye eye NN cord-316789-nb4437qs 83 27 imaginal imaginal JJ cord-316789-nb4437qs 83 28 disc disc NN cord-316789-nb4437qs 83 29 and and CC cord-316789-nb4437qs 83 30 an an DT cord-316789-nb4437qs 83 31 intensification intensification NN cord-316789-nb4437qs 83 32 of of IN cord-316789-nb4437qs 83 33 cell cell NN cord-316789-nb4437qs 83 34 apoptosis apoptosis NN cord-316789-nb4437qs 83 35 . . . cord-316789-nb4437qs 84 1 This this DT cord-316789-nb4437qs 84 2 is be VBZ cord-316789-nb4437qs 84 3 in in IN cord-316789-nb4437qs 84 4 good good JJ cord-316789-nb4437qs 84 5 agreement agreement NN cord-316789-nb4437qs 84 6 with with IN cord-316789-nb4437qs 84 7 the the DT cord-316789-nb4437qs 84 8 data datum NNS cord-316789-nb4437qs 84 9 obtained obtain VBN cord-316789-nb4437qs 84 10 for for IN cord-316789-nb4437qs 84 11 human human JJ cord-316789-nb4437qs 84 12 cells cell NNS cord-316789-nb4437qs 84 13 that that WDT cord-316789-nb4437qs 84 14 demonstrate demonstrate VBP cord-316789-nb4437qs 84 15 a a DT cord-316789-nb4437qs 84 16 cell cell NN cord-316789-nb4437qs 84 17 cycle cycle NN cord-316789-nb4437qs 84 18 arrest arrest NN cord-316789-nb4437qs 84 19 under under IN cord-316789-nb4437qs 84 20 the the DT cord-316789-nb4437qs 84 21 action action NN cord-316789-nb4437qs 84 22 of of IN cord-316789-nb4437qs 84 23 BZLF1 BZLF1 NNP cord-316789-nb4437qs 84 24 . . . cord-316789-nb4437qs 85 1 Then then RB cord-316789-nb4437qs 85 2 Adamson Adamson NNP cord-316789-nb4437qs 85 3 et et NNP cord-316789-nb4437qs 85 4 al al NNP cord-316789-nb4437qs 85 5 . . . cord-316789-nb4437qs 86 1 [ [ -LRB- cord-316789-nb4437qs 86 2 26 26 CD cord-316789-nb4437qs 86 3 ] ] -RRB- cord-316789-nb4437qs 86 4 checked check VBN cord-316789-nb4437qs 86 5 , , , cord-316789-nb4437qs 86 6 using use VBG cord-316789-nb4437qs 86 7 antibod antibod NNP cord-316789-nb4437qs 86 8 ies ie NNS cord-316789-nb4437qs 86 9 against against IN cord-316789-nb4437qs 86 10 the the DT cord-316789-nb4437qs 86 11 Drosophila Drosophila NNP cord-316789-nb4437qs 86 12 eye eye NN cord-316789-nb4437qs 86 13 protein protein NN cord-316789-nb4437qs 86 14 Elav Elav NNP cord-316789-nb4437qs 86 15 , , , cord-316789-nb4437qs 86 16 whether whether IN cord-316789-nb4437qs 86 17 BZLF1 bzlf1 JJ cord-316789-nb4437qs 86 18 acts act NNS cord-316789-nb4437qs 86 19 on on IN cord-316789-nb4437qs 86 20 differentiating differentiate VBG cord-316789-nb4437qs 86 21 photoreceptors photoreceptor NNS cord-316789-nb4437qs 86 22 of of IN cord-316789-nb4437qs 86 23 the the DT cord-316789-nb4437qs 86 24 eye eye NN cord-316789-nb4437qs 86 25 . . . cord-316789-nb4437qs 87 1 It -PRON- PRP cord-316789-nb4437qs 87 2 turned turn VBD cord-316789-nb4437qs 87 3 out out RP cord-316789-nb4437qs 87 4 that that IN cord-316789-nb4437qs 87 5 the the DT cord-316789-nb4437qs 87 6 protein protein NN cord-316789-nb4437qs 87 7 had have VBD cord-316789-nb4437qs 87 8 no no DT cord-316789-nb4437qs 87 9 influence influence NN cord-316789-nb4437qs 87 10 on on IN cord-316789-nb4437qs 87 11 the the DT cord-316789-nb4437qs 87 12 cells cell NNS cord-316789-nb4437qs 87 13 of of IN cord-316789-nb4437qs 87 14 the the DT cord-316789-nb4437qs 87 15 photoreceptors photoreceptor NNS cord-316789-nb4437qs 87 16 at at IN cord-316789-nb4437qs 87 17 this this DT cord-316789-nb4437qs 87 18 , , , cord-316789-nb4437qs 87 19 later later RB cord-316789-nb4437qs 87 20 , , , cord-316789-nb4437qs 87 21 stage stage NN cord-316789-nb4437qs 87 22 . . . cord-316789-nb4437qs 88 1 In in IN cord-316789-nb4437qs 88 2 addition addition NN cord-316789-nb4437qs 88 3 , , , cord-316789-nb4437qs 88 4 the the DT cord-316789-nb4437qs 88 5 authors author NNS cord-316789-nb4437qs 88 6 activated activate VBD cord-316789-nb4437qs 88 7 the the DT cord-316789-nb4437qs 88 8 UAS UAS NNP cord-316789-nb4437qs 88 9 BZLF1 BZLF1 NNP cord-316789-nb4437qs 88 10 transgene transgene NN cord-316789-nb4437qs 88 11 with with IN cord-316789-nb4437qs 88 12 the the DT cord-316789-nb4437qs 88 13 use use NN cord-316789-nb4437qs 88 14 of of IN cord-316789-nb4437qs 88 15 the the DT cord-316789-nb4437qs 88 16 sev sev NNP cord-316789-nb4437qs 88 17 Gal4 Gal4 NNP cord-316789-nb4437qs 88 18 driver driver NN cord-316789-nb4437qs 88 19 ( ( -LRB- cord-316789-nb4437qs 88 20 it -PRON- PRP cord-316789-nb4437qs 88 21 acts act VBZ cord-316789-nb4437qs 88 22 later later RB cord-316789-nb4437qs 88 23 than than IN cord-316789-nb4437qs 88 24 elav elav NNP cord-316789-nb4437qs 88 25 ) ) -RRB- cord-316789-nb4437qs 88 26 and and CC cord-316789-nb4437qs 88 27 confirmed confirm VBD cord-316789-nb4437qs 88 28 the the DT cord-316789-nb4437qs 88 29 lack lack NN cord-316789-nb4437qs 88 30 of of IN cord-316789-nb4437qs 88 31 the the DT cord-316789-nb4437qs 88 32 eye eye NN cord-316789-nb4437qs 88 33 phe phe NN cord-316789-nb4437qs 88 34 notype notype NN cord-316789-nb4437qs 88 35 . . . cord-316789-nb4437qs 89 1 It -PRON- PRP cord-316789-nb4437qs 89 2 was be VBD cord-316789-nb4437qs 89 3 further further RB cord-316789-nb4437qs 89 4 found find VBN cord-316789-nb4437qs 89 5 that that IN cord-316789-nb4437qs 89 6 in in IN cord-316789-nb4437qs 89 7 the the DT cord-316789-nb4437qs 89 8 case case NN cord-316789-nb4437qs 89 9 of of IN cord-316789-nb4437qs 89 10 BZLF1 BZLF1 NNP cord-316789-nb4437qs 89 11 overexpression overexpression NN cord-316789-nb4437qs 89 12 the the DT cord-316789-nb4437qs 89 13 eye eye NN cord-316789-nb4437qs 89 14 conic conic JJ cord-316789-nb4437qs 89 15 cells cell NNS cord-316789-nb4437qs 89 16 lose lose VBP cord-316789-nb4437qs 89 17 Cut Cut VBN cord-316789-nb4437qs 89 18 protein protein NN cord-316789-nb4437qs 89 19 expression expression NN cord-316789-nb4437qs 89 20 . . . cord-316789-nb4437qs 90 1 The the DT cord-316789-nb4437qs 90 2 protein protein NN cord-316789-nb4437qs 90 3 Shaven Shaven NNP cord-316789-nb4437qs 90 4 ( ( -LRB- cord-316789-nb4437qs 90 5 encoded encode VBN cord-316789-nb4437qs 90 6 by by IN cord-316789-nb4437qs 90 7 the the DT cord-316789-nb4437qs 90 8 sv sv NNP cord-316789-nb4437qs 90 9 gene gene NN cord-316789-nb4437qs 90 10 ) ) -RRB- cord-316789-nb4437qs 90 11 normally normally RB cord-316789-nb4437qs 90 12 activates activate VBZ cord-316789-nb4437qs 90 13 the the DT cord-316789-nb4437qs 90 14 expression expression NN cord-316789-nb4437qs 90 15 of of IN cord-316789-nb4437qs 90 16 cut cut NN cord-316789-nb4437qs 90 17 in in IN cord-316789-nb4437qs 90 18 these these DT cord-316789-nb4437qs 90 19 cells cell NNS cord-316789-nb4437qs 90 20 by by IN cord-316789-nb4437qs 90 21 binding bind VBG cord-316789-nb4437qs 90 22 with with IN cord-316789-nb4437qs 90 23 its -PRON- PRP$ cord-316789-nb4437qs 90 24 promoter promoter NN cord-316789-nb4437qs 90 25 . . . cord-316789-nb4437qs 91 1 Using use VBG cord-316789-nb4437qs 91 2 anti anti JJ cord-316789-nb4437qs 91 3 Shaven Shaven NNP cord-316789-nb4437qs 91 4 antibodies antibody NNS cord-316789-nb4437qs 91 5 , , , cord-316789-nb4437qs 91 6 the the DT cord-316789-nb4437qs 91 7 authors author NNS cord-316789-nb4437qs 91 8 demonstrated demonstrate VBD cord-316789-nb4437qs 91 9 that that IN cord-316789-nb4437qs 91 10 BZLF1 bzlf1 JJ cord-316789-nb4437qs 91 11 expression expression NN cord-316789-nb4437qs 91 12 affects affect VBZ cord-316789-nb4437qs 91 13 the the DT cord-316789-nb4437qs 91 14 localization localization NN cord-316789-nb4437qs 91 15 of of IN cord-316789-nb4437qs 91 16 Shaven Shaven NNP cord-316789-nb4437qs 91 17 and and CC cord-316789-nb4437qs 91 18 the the DT cord-316789-nb4437qs 91 19 level level NN cord-316789-nb4437qs 91 20 of of IN cord-316789-nb4437qs 91 21 its -PRON- PRP$ cord-316789-nb4437qs 91 22 expression expression NN cord-316789-nb4437qs 91 23 . . . cord-316789-nb4437qs 92 1 The the DT cord-316789-nb4437qs 92 2 authors author NNS cord-316789-nb4437qs 92 3 assumed assume VBD cord-316789-nb4437qs 92 4 that that IN cord-316789-nb4437qs 92 5 the the DT cord-316789-nb4437qs 92 6 virul virul NNP cord-316789-nb4437qs 92 7 protein protein NN cord-316789-nb4437qs 92 8 influences influence VBZ cord-316789-nb4437qs 92 9 the the DT cord-316789-nb4437qs 92 10 process process NN cord-316789-nb4437qs 92 11 of of IN cord-316789-nb4437qs 92 12 Cut cut VB cord-316789-nb4437qs 92 13 transactiva transactiva NN cord-316789-nb4437qs 92 14 tion tion NN cord-316789-nb4437qs 92 15 with with IN cord-316789-nb4437qs 92 16 the the DT cord-316789-nb4437qs 92 17 help help NN cord-316789-nb4437qs 92 18 of of IN cord-316789-nb4437qs 92 19 Shaven Shaven NNP cord-316789-nb4437qs 92 20 . . . cord-316789-nb4437qs 93 1 By by IN cord-316789-nb4437qs 93 2 comparing compare VBG cord-316789-nb4437qs 93 3 the the DT cord-316789-nb4437qs 93 4 eye eye NN cord-316789-nb4437qs 93 5 morphology morphology NN cord-316789-nb4437qs 93 6 in in IN cord-316789-nb4437qs 93 7 sv/+ sv/+ NN cord-316789-nb4437qs 93 8 and and CC cord-316789-nb4437qs 93 9 BZLF1/+ bzlf1/+ NN cord-316789-nb4437qs 93 10 ; ; , cord-316789-nb4437qs 93 11 sv/+ sv/+ VB cord-316789-nb4437qs 93 12 individuals individual NNS cord-316789-nb4437qs 93 13 , , , cord-316789-nb4437qs 93 14 the the DT cord-316789-nb4437qs 93 15 authors author NNS cord-316789-nb4437qs 93 16 revealed reveal VBD cord-316789-nb4437qs 93 17 genetic genetic JJ cord-316789-nb4437qs 93 18 interactions interaction NNS cord-316789-nb4437qs 93 19 between between IN cord-316789-nb4437qs 93 20 sv sv NNP cord-316789-nb4437qs 93 21 and and CC cord-316789-nb4437qs 93 22 BZLF1 BZLF1 NNP cord-316789-nb4437qs 93 23 . . . cord-316789-nb4437qs 94 1 On on IN cord-316789-nb4437qs 94 2 the the DT cord-316789-nb4437qs 94 3 basis basis NN cord-316789-nb4437qs 94 4 of of IN cord-316789-nb4437qs 94 5 this this DT cord-316789-nb4437qs 94 6 finding finding NN cord-316789-nb4437qs 94 7 , , , cord-316789-nb4437qs 94 8 the the DT cord-316789-nb4437qs 94 9 authors author NNS cord-316789-nb4437qs 94 10 proceeded proceed VBD cord-316789-nb4437qs 94 11 to to IN cord-316789-nb4437qs 94 12 studying study VBG cord-316789-nb4437qs 94 13 human human JJ cord-316789-nb4437qs 94 14 homologs homolog NNS cord-316789-nb4437qs 94 15 of of IN cord-316789-nb4437qs 94 16 Shaven Shaven NNP cord-316789-nb4437qs 94 17 : : : cord-316789-nb4437qs 94 18 proteins protein NNS cord-316789-nb4437qs 94 19 Pax2 Pax2 NNP cord-316789-nb4437qs 94 20 , , , cord-316789-nb4437qs 94 21 Pax5 Pax5 NNP cord-316789-nb4437qs 94 22 , , , cord-316789-nb4437qs 94 23 and and CC cord-316789-nb4437qs 94 24 Pax8 Pax8 NNP cord-316789-nb4437qs 94 25 . . . cord-316789-nb4437qs 95 1 Since since IN cord-316789-nb4437qs 95 2 the the DT cord-316789-nb4437qs 95 3 Epstein Epstein NNP cord-316789-nb4437qs 95 4 - - HYPH cord-316789-nb4437qs 95 5 Barr Barr NNP cord-316789-nb4437qs 95 6 virus virus NN cord-316789-nb4437qs 95 7 infects infect VBZ cord-316789-nb4437qs 95 8 B b NN cord-316789-nb4437qs 95 9 cells cell NNS cord-316789-nb4437qs 95 10 of of IN cord-316789-nb4437qs 95 11 the the DT cord-316789-nb4437qs 95 12 human human JJ cord-316789-nb4437qs 95 13 immune immune NN cord-316789-nb4437qs 95 14 sys sys NNP cord-316789-nb4437qs 95 15 tem tem NN cord-316789-nb4437qs 95 16 , , , cord-316789-nb4437qs 95 17 in in IN cord-316789-nb4437qs 95 18 which which WDT cord-316789-nb4437qs 95 19 Pax5 Pax5 NNP cord-316789-nb4437qs 95 20 is be VBZ cord-316789-nb4437qs 95 21 functional functional JJ cord-316789-nb4437qs 95 22 , , , cord-316789-nb4437qs 95 23 rather rather RB cord-316789-nb4437qs 95 24 than than IN cord-316789-nb4437qs 95 25 the the DT cord-316789-nb4437qs 95 26 Pax2 Pax2 NNP cord-316789-nb4437qs 95 27 and and CC cord-316789-nb4437qs 95 28 Pax8 Pax8 NNP cord-316789-nb4437qs 95 29 homologs homolog NNS cord-316789-nb4437qs 95 30 , , , cord-316789-nb4437qs 95 31 the the DT cord-316789-nb4437qs 95 32 authors author NNS cord-316789-nb4437qs 95 33 tried try VBD cord-316789-nb4437qs 95 34 to to TO cord-316789-nb4437qs 95 35 elucidate elucidate VB cord-316789-nb4437qs 95 36 whether whether IN cord-316789-nb4437qs 95 37 the the DT cord-316789-nb4437qs 95 38 proteins protein NNS cord-316789-nb4437qs 95 39 BZLF1 BZLF1 NNP cord-316789-nb4437qs 95 40 and and CC cord-316789-nb4437qs 95 41 Pax5 Pax5 NNP cord-316789-nb4437qs 95 42 form form VB cord-316789-nb4437qs 95 43 a a DT cord-316789-nb4437qs 95 44 com com NN cord-316789-nb4437qs 95 45 plex plex NN cord-316789-nb4437qs 95 46 . . . cord-316789-nb4437qs 96 1 It -PRON- PRP cord-316789-nb4437qs 96 2 was be VBD cord-316789-nb4437qs 96 3 found find VBN cord-316789-nb4437qs 96 4 that that IN cord-316789-nb4437qs 96 5 these these DT cord-316789-nb4437qs 96 6 proteins protein NNS cord-316789-nb4437qs 96 7 are be VBP cord-316789-nb4437qs 96 8 able able JJ cord-316789-nb4437qs 96 9 to to TO cord-316789-nb4437qs 96 10 form form VB cord-316789-nb4437qs 96 11 a a DT cord-316789-nb4437qs 96 12 complex complex NN cord-316789-nb4437qs 96 13 and and CC cord-316789-nb4437qs 96 14 that that IN cord-316789-nb4437qs 96 15 the the DT cord-316789-nb4437qs 96 16 formation formation NN cord-316789-nb4437qs 96 17 of of IN cord-316789-nb4437qs 96 18 a a DT cord-316789-nb4437qs 96 19 complex complex JJ cord-316789-nb4437qs 96 20 causes cause NNS cord-316789-nb4437qs 96 21 binding binding NN cord-316789-nb4437qs 96 22 of of IN cord-316789-nb4437qs 96 23 BZLF1 BZLF1 NNP cord-316789-nb4437qs 96 24 with with IN cord-316789-nb4437qs 96 25 mitotic mitotic JJ cord-316789-nb4437qs 96 26 chromosomes chromosome NNS cord-316789-nb4437qs 96 27 . . . cord-316789-nb4437qs 97 1 Thus thus RB cord-316789-nb4437qs 97 2 , , , cord-316789-nb4437qs 97 3 the the DT cord-316789-nb4437qs 97 4 authors author NNS cord-316789-nb4437qs 97 5 of of IN cord-316789-nb4437qs 97 6 this this DT cord-316789-nb4437qs 97 7 work work NN cord-316789-nb4437qs 97 8 succeeded succeed VBD cord-316789-nb4437qs 97 9 in in IN cord-316789-nb4437qs 97 10 discovering discover VBG cord-316789-nb4437qs 97 11 and and CC cord-316789-nb4437qs 97 12 characterizing characterize VBG cord-316789-nb4437qs 97 13 the the DT cord-316789-nb4437qs 97 14 human human JJ cord-316789-nb4437qs 97 15 virul virul NN cord-316789-nb4437qs 97 16 protein protein NN cord-316789-nb4437qs 97 17 with with IN cord-316789-nb4437qs 97 18 the the DT cord-316789-nb4437qs 97 19 employment employment NN cord-316789-nb4437qs 97 20 of of IN cord-316789-nb4437qs 97 21 the the DT cord-316789-nb4437qs 97 22 methods method NNS cord-316789-nb4437qs 97 23 of of IN cord-316789-nb4437qs 97 24 molecular molecular JJ cord-316789-nb4437qs 97 25 genetics genetic NNS cord-316789-nb4437qs 97 26 of of IN cord-316789-nb4437qs 97 27 Drosophila Drosophila NNP cord-316789-nb4437qs 97 28 . . . cord-316789-nb4437qs 98 1 The the DT cord-316789-nb4437qs 98 2 results result NNS cord-316789-nb4437qs 98 3 obtained obtain VBN cord-316789-nb4437qs 98 4 and and CC cord-316789-nb4437qs 98 5 the the DT cord-316789-nb4437qs 98 6 existence existence NN cord-316789-nb4437qs 98 7 of of IN cord-316789-nb4437qs 98 8 homology homology NN cord-316789-nb4437qs 98 9 between between IN cord-316789-nb4437qs 98 10 the the DT cord-316789-nb4437qs 98 11 human human JJ cord-316789-nb4437qs 98 12 and and CC cord-316789-nb4437qs 98 13 Drosophila Drosophila NNP cord-316789-nb4437qs 98 14 proteins protein NNS cord-316789-nb4437qs 98 15 enabled enable VBD cord-316789-nb4437qs 98 16 the the DT cord-316789-nb4437qs 98 17 authors author NNS cord-316789-nb4437qs 98 18 to to TO cord-316789-nb4437qs 98 19 return return VB cord-316789-nb4437qs 98 20 to to IN cord-316789-nb4437qs 98 21 studying study VBG cord-316789-nb4437qs 98 22 the the DT cord-316789-nb4437qs 98 23 action action NN cord-316789-nb4437qs 98 24 of of IN cord-316789-nb4437qs 98 25 the the DT cord-316789-nb4437qs 98 26 human human JJ cord-316789-nb4437qs 98 27 proteins protein NNS cord-316789-nb4437qs 98 28 . . . cord-316789-nb4437qs 99 1 Embryonic embryonic JJ cord-316789-nb4437qs 99 2 infection infection NN cord-316789-nb4437qs 99 3 by by IN cord-316789-nb4437qs 99 4 the the DT cord-316789-nb4437qs 99 5 human human JJ cord-316789-nb4437qs 99 6 cytomegalovirus cytomegalovirus NN cord-316789-nb4437qs 99 7 ( ( -LRB- cord-316789-nb4437qs 99 8 HCMV HCMV NNP cord-316789-nb4437qs 99 9 ) ) -RRB- cord-316789-nb4437qs 99 10 leads lead VBZ cord-316789-nb4437qs 99 11 to to IN cord-316789-nb4437qs 99 12 microencephalia microencephalia NNP cord-316789-nb4437qs 99 13 , , , cord-316789-nb4437qs 99 14 microgyria microgyria NNP cord-316789-nb4437qs 99 15 , , , cord-316789-nb4437qs 99 16 and and CC cord-316789-nb4437qs 99 17 hydrocephalus hydrocephalus NN cord-316789-nb4437qs 99 18 [ [ -LRB- cord-316789-nb4437qs 99 19 27 27 CD cord-316789-nb4437qs 99 20 ] ] -RRB- cord-316789-nb4437qs 99 21 . . . cord-316789-nb4437qs 100 1 Transgenic transgenic JJ cord-316789-nb4437qs 100 2 constructs construct NNS cord-316789-nb4437qs 100 3 were be VBD cord-316789-nb4437qs 100 4 obtained obtain VBN cord-316789-nb4437qs 100 5 in in IN cord-316789-nb4437qs 100 6 the the DT cord-316789-nb4437qs 100 7 work work NN cord-316789-nb4437qs 100 8 [ [ -LRB- cord-316789-nb4437qs 100 9 28 28 CD cord-316789-nb4437qs 100 10 ] ] -RRB- cord-316789-nb4437qs 100 11 , , , cord-316789-nb4437qs 100 12 of of IN cord-316789-nb4437qs 100 13 which which WDT cord-316789-nb4437qs 100 14 one one CD cord-316789-nb4437qs 100 15 contained contain VBD cord-316789-nb4437qs 100 16 the the DT cord-316789-nb4437qs 100 17 Major Major NNP cord-316789-nb4437qs 100 18 Immediate Immediate NNP cord-316789-nb4437qs 100 19 Early early JJ cord-316789-nb4437qs 100 20 promoter promoter NN cord-316789-nb4437qs 100 21 ( ( -LRB- cord-316789-nb4437qs 100 22 MIEP MIEP NNP cord-316789-nb4437qs 100 23 ) ) -RRB- cord-316789-nb4437qs 100 24 of of IN cord-316789-nb4437qs 100 25 HCMV HCMV NNP cord-316789-nb4437qs 100 26 attached attach VBN cord-316789-nb4437qs 100 27 to to IN cord-316789-nb4437qs 100 28 the the DT cord-316789-nb4437qs 100 29 coding code VBG cord-316789-nb4437qs 100 30 region region NN cord-316789-nb4437qs 100 31 of of IN cord-316789-nb4437qs 100 32 the the DT cord-316789-nb4437qs 100 33 YFP YFP NNP cord-316789-nb4437qs 100 34 reporter reporter NN cord-316789-nb4437qs 100 35 . . . cord-316789-nb4437qs 101 1 Another another DT cord-316789-nb4437qs 101 2 con con NN cord-316789-nb4437qs 101 3 struct struct NN cord-316789-nb4437qs 101 4 contained contain VBD cord-316789-nb4437qs 101 5 two two CD cord-316789-nb4437qs 101 6 viral viral JJ cord-316789-nb4437qs 101 7 genes gene NNS cord-316789-nb4437qs 101 8 , , , cord-316789-nb4437qs 101 9 IE72 IE72 NNP cord-316789-nb4437qs 101 10 and and CC cord-316789-nb4437qs 101 11 IE86 IE86 NNP cord-316789-nb4437qs 101 12 , , , cord-316789-nb4437qs 101 13 under under IN cord-316789-nb4437qs 101 14 the the DT cord-316789-nb4437qs 101 15 control control NN cord-316789-nb4437qs 101 16 of of IN cord-316789-nb4437qs 101 17 the the DT cord-316789-nb4437qs 101 18 hs hs NNP cord-316789-nb4437qs 101 19 promoter promoter NN cord-316789-nb4437qs 101 20 of of IN cord-316789-nb4437qs 101 21 the the DT cord-316789-nb4437qs 101 22 pCasPeR pcasper JJ cord-316789-nb4437qs 101 23 vector vector NN cord-316789-nb4437qs 101 24 . . . cord-316789-nb4437qs 102 1 The the DT cord-316789-nb4437qs 102 2 promoter promoter NN cord-316789-nb4437qs 102 3 activity activity NN cord-316789-nb4437qs 102 4 was be VBD cord-316789-nb4437qs 102 5 detectable detectable JJ cord-316789-nb4437qs 102 6 only only RB cord-316789-nb4437qs 102 7 in in IN cord-316789-nb4437qs 102 8 early early JJ cord-316789-nb4437qs 102 9 embryos embryo NNS cord-316789-nb4437qs 102 10 at at IN cord-316789-nb4437qs 102 11 the the DT cord-316789-nb4437qs 102 12 stage stage NN cord-316789-nb4437qs 102 13 of of IN cord-316789-nb4437qs 102 14 blastoderm blastoderm NN cord-316789-nb4437qs 102 15 . . . cord-316789-nb4437qs 103 1 This this DT cord-316789-nb4437qs 103 2 fact fact NN cord-316789-nb4437qs 103 3 agrees agree VBZ cord-316789-nb4437qs 103 4 well well RB cord-316789-nb4437qs 103 5 with with IN cord-316789-nb4437qs 103 6 the the DT cord-316789-nb4437qs 103 7 data datum NNS cord-316789-nb4437qs 103 8 on on IN cord-316789-nb4437qs 103 9 the the DT cord-316789-nb4437qs 103 10 expression expression NN cord-316789-nb4437qs 103 11 of of IN cord-316789-nb4437qs 103 12 this this DT cord-316789-nb4437qs 103 13 promoter promoter NN cord-316789-nb4437qs 103 14 in in IN cord-316789-nb4437qs 103 15 mouse mouse NN cord-316789-nb4437qs 103 16 embryos embryo NNS cord-316789-nb4437qs 103 17 and and CC cord-316789-nb4437qs 103 18 is be VBZ cord-316789-nb4437qs 103 19 a a DT cord-316789-nb4437qs 103 20 strong strong JJ cord-316789-nb4437qs 103 21 argument argument NN cord-316789-nb4437qs 103 22 in in IN cord-316789-nb4437qs 103 23 favor favor NN cord-316789-nb4437qs 103 24 of of IN cord-316789-nb4437qs 103 25 using use VBG cord-316789-nb4437qs 103 26 Droso Droso NNP cord-316789-nb4437qs 103 27 phila phila NNP cord-316789-nb4437qs 103 28 as as IN cord-316789-nb4437qs 103 29 a a DT cord-316789-nb4437qs 103 30 model model NN cord-316789-nb4437qs 103 31 object object NN cord-316789-nb4437qs 103 32 for for IN cord-316789-nb4437qs 103 33 studying study VBG cord-316789-nb4437qs 103 34 viral viral JJ cord-316789-nb4437qs 103 35 infections infection NNS cord-316789-nb4437qs 103 36 . . . cord-316789-nb4437qs 104 1 Moreover moreover RB cord-316789-nb4437qs 104 2 , , , cord-316789-nb4437qs 104 3 the the DT cord-316789-nb4437qs 104 4 viral viral JJ cord-316789-nb4437qs 104 5 proteins protein NNS cord-316789-nb4437qs 104 6 under under IN cord-316789-nb4437qs 104 7 study study NN cord-316789-nb4437qs 104 8 were be VBD cord-316789-nb4437qs 104 9 found find VBN cord-316789-nb4437qs 104 10 to to TO cord-316789-nb4437qs 104 11 be be VB cord-316789-nb4437qs 104 12 localized localize VBN cord-316789-nb4437qs 104 13 in in IN cord-316789-nb4437qs 104 14 the the DT cord-316789-nb4437qs 104 15 nucleus nucleus NN cord-316789-nb4437qs 104 16 . . . cord-316789-nb4437qs 105 1 Such such JJ cord-316789-nb4437qs 105 2 a a DT cord-316789-nb4437qs 105 3 localization localization NN cord-316789-nb4437qs 105 4 is be VBZ cord-316789-nb4437qs 105 5 expected expect VBN cord-316789-nb4437qs 105 6 for for IN cord-316789-nb4437qs 105 7 transcription transcription NN cord-316789-nb4437qs 105 8 factors factor NNS cord-316789-nb4437qs 105 9 . . . cord-316789-nb4437qs 106 1 Overexpression overexpression NN cord-316789-nb4437qs 106 2 of of IN cord-316789-nb4437qs 106 3 the the DT cord-316789-nb4437qs 106 4 construct construct NN cord-316789-nb4437qs 106 5 containing contain VBG cord-316789-nb4437qs 106 6 viral viral JJ cord-316789-nb4437qs 106 7 genes gene NNS cord-316789-nb4437qs 106 8 leads lead VBZ cord-316789-nb4437qs 106 9 to to IN cord-316789-nb4437qs 106 10 the the DT cord-316789-nb4437qs 106 11 death death NN cord-316789-nb4437qs 106 12 of of IN cord-316789-nb4437qs 106 13 20 20 CD cord-316789-nb4437qs 106 14 - - SYM cord-316789-nb4437qs 106 15 30 30 CD cord-316789-nb4437qs 106 16 % % NN cord-316789-nb4437qs 106 17 of of IN cord-316789-nb4437qs 106 18 embryos embryo NNS cord-316789-nb4437qs 106 19 with with IN cord-316789-nb4437qs 106 20 a a DT cord-316789-nb4437qs 106 21 phenotype phenotype NN cord-316789-nb4437qs 106 22 called call VBN cord-316789-nb4437qs 106 23 by by IN cord-316789-nb4437qs 106 24 the the DT cord-316789-nb4437qs 106 25 authors author NNS cord-316789-nb4437qs 106 26 " " `` cord-316789-nb4437qs 106 27 frag frag VBP cord-316789-nb4437qs 106 28 mented mente VBN cord-316789-nb4437qs 106 29 embryo embryo NN cord-316789-nb4437qs 106 30 . . . cord-316789-nb4437qs 106 31 " " '' cord-316789-nb4437qs 107 1 Normally normally RB cord-316789-nb4437qs 107 2 , , , cord-316789-nb4437qs 107 3 DE DE NNP cord-316789-nb4437qs 107 4 cadherin cadherin NN cord-316789-nb4437qs 107 5 in in IN cord-316789-nb4437qs 107 6 Drosophila Drosophila NNP cord-316789-nb4437qs 107 7 binds bind VBZ cord-316789-nb4437qs 107 8 to to IN cord-316789-nb4437qs 107 9 the the DT cord-316789-nb4437qs 107 10 Arm Arm NNP cord-316789-nb4437qs 107 11 protein protein NN cord-316789-nb4437qs 107 12 . . . cord-316789-nb4437qs 108 1 Both both DT cord-316789-nb4437qs 108 2 proteins protein NNS cord-316789-nb4437qs 108 3 are be VBP cord-316789-nb4437qs 108 4 major major JJ cord-316789-nb4437qs 108 5 com com NN cord-316789-nb4437qs 108 6 ponents ponent NNS cord-316789-nb4437qs 108 7 of of IN cord-316789-nb4437qs 108 8 intercellular intercellular JJ cord-316789-nb4437qs 108 9 contacts contact NNS cord-316789-nb4437qs 108 10 ( ( -LRB- cord-316789-nb4437qs 108 11 adherence adherence NN cord-316789-nb4437qs 108 12 junctions junction NNS cord-316789-nb4437qs 108 13 ) ) -RRB- cord-316789-nb4437qs 108 14 . . . cord-316789-nb4437qs 109 1 While while IN cord-316789-nb4437qs 109 2 the the DT cord-316789-nb4437qs 109 3 localization localization NN cord-316789-nb4437qs 109 4 of of IN cord-316789-nb4437qs 109 5 DE DE NNP cord-316789-nb4437qs 109 6 cadherin cadherin NN cord-316789-nb4437qs 109 7 in in IN cord-316789-nb4437qs 109 8 transgenic transgenic JJ cord-316789-nb4437qs 109 9 embryos embryo NNS cord-316789-nb4437qs 109 10 overexpressing overexpresse VBG cord-316789-nb4437qs 109 11 a a DT cord-316789-nb4437qs 109 12 cassette cassette NN cord-316789-nb4437qs 109 13 of of IN cord-316789-nb4437qs 109 14 viral viral JJ cord-316789-nb4437qs 109 15 transgenes transgene NNS cord-316789-nb4437qs 109 16 remains remain VBZ cord-316789-nb4437qs 109 17 unchanged unchanged JJ cord-316789-nb4437qs 109 18 , , , cord-316789-nb4437qs 109 19 the the DT cord-316789-nb4437qs 109 20 pattern pattern NN cord-316789-nb4437qs 109 21 of of IN cord-316789-nb4437qs 109 22 Arm Arm NNP cord-316789-nb4437qs 109 23 expression expression NN cord-316789-nb4437qs 109 24 rep rep NN cord-316789-nb4437qs 109 25 resenting resent VBG cord-316789-nb4437qs 109 26 a a DT cord-316789-nb4437qs 109 27 system system NN cord-316789-nb4437qs 109 28 of of IN cord-316789-nb4437qs 109 29 bands band NNS cord-316789-nb4437qs 109 30 changes change VBZ cord-316789-nb4437qs 109 31 up up RP cord-316789-nb4437qs 109 32 to to IN cord-316789-nb4437qs 109 33 becoming become VBG cord-316789-nb4437qs 109 34 uni uni JJ cord-316789-nb4437qs 109 35 form form NN cord-316789-nb4437qs 109 36 . . . cord-316789-nb4437qs 110 1 The the DT cord-316789-nb4437qs 110 2 authors author NNS cord-316789-nb4437qs 110 3 concluded conclude VBD cord-316789-nb4437qs 110 4 that that IN cord-316789-nb4437qs 110 5 the the DT cord-316789-nb4437qs 110 6 viral viral JJ cord-316789-nb4437qs 110 7 transgenes transgene NNS cord-316789-nb4437qs 110 8 alter alter VBP cord-316789-nb4437qs 110 9 the the DT cord-316789-nb4437qs 110 10 composition composition NN cord-316789-nb4437qs 110 11 of of IN cord-316789-nb4437qs 110 12 adherence adherence NN cord-316789-nb4437qs 110 13 junctions junction NNS cord-316789-nb4437qs 110 14 in in IN cord-316789-nb4437qs 110 15 embryos embryo NNS cord-316789-nb4437qs 110 16 . . . cord-316789-nb4437qs 111 1 The the DT cord-316789-nb4437qs 111 2 rabies rabies NN cord-316789-nb4437qs 111 3 virus virus NN cord-316789-nb4437qs 111 4 , , , cord-316789-nb4437qs 111 5 able able JJ cord-316789-nb4437qs 111 6 to to TO cord-316789-nb4437qs 111 7 infect infect VB cord-316789-nb4437qs 111 8 different different JJ cord-316789-nb4437qs 111 9 mammals mammal NNS cord-316789-nb4437qs 111 10 , , , cord-316789-nb4437qs 111 11 is be VBZ cord-316789-nb4437qs 111 12 considered consider VBN cord-316789-nb4437qs 111 13 to to TO cord-316789-nb4437qs 111 14 have have VB cord-316789-nb4437qs 111 15 the the DT cord-316789-nb4437qs 111 16 widest wide JJS cord-316789-nb4437qs 111 17 range range NN cord-316789-nb4437qs 111 18 of of IN cord-316789-nb4437qs 111 19 hosts host NNS cord-316789-nb4437qs 111 20 among among IN cord-316789-nb4437qs 111 21 ani ani NNP cord-316789-nb4437qs 111 22 mal mal NNP cord-316789-nb4437qs 111 23 viruses virus NNS cord-316789-nb4437qs 111 24 . . . cord-316789-nb4437qs 112 1 At at IN cord-316789-nb4437qs 112 2 the the DT cord-316789-nb4437qs 112 3 same same JJ cord-316789-nb4437qs 112 4 time time NN cord-316789-nb4437qs 112 5 , , , cord-316789-nb4437qs 112 6 the the DT cord-316789-nb4437qs 112 7 action action NN cord-316789-nb4437qs 112 8 of of IN cord-316789-nb4437qs 112 9 many many JJ cord-316789-nb4437qs 112 10 animal animal NN cord-316789-nb4437qs 112 11 viruses virus NNS cord-316789-nb4437qs 112 12 is be VBZ cord-316789-nb4437qs 112 13 species specie NNS cord-316789-nb4437qs 112 14 specific specific JJ cord-316789-nb4437qs 112 15 [ [ -LRB- cord-316789-nb4437qs 112 16 29 29 CD cord-316789-nb4437qs 112 17 ] ] -RRB- cord-316789-nb4437qs 112 18 . . . cord-316789-nb4437qs 113 1 The the DT cord-316789-nb4437qs 113 2 question question NN cord-316789-nb4437qs 113 3 arises arise VBZ cord-316789-nb4437qs 113 4 as as IN cord-316789-nb4437qs 113 5 to to IN cord-316789-nb4437qs 113 6 whether whether IN cord-316789-nb4437qs 113 7 the the DT cord-316789-nb4437qs 113 8 range range NN cord-316789-nb4437qs 113 9 of of IN cord-316789-nb4437qs 113 10 hosts host NNS cord-316789-nb4437qs 113 11 is be VBZ cord-316789-nb4437qs 113 12 limited limit VBN cord-316789-nb4437qs 113 13 by by IN cord-316789-nb4437qs 113 14 genes gene NNS cord-316789-nb4437qs 113 15 determin determin VBP cord-316789-nb4437qs 113 16 ing e VBG cord-316789-nb4437qs 113 17 the the DT cord-316789-nb4437qs 113 18 penetration penetration NN cord-316789-nb4437qs 113 19 of of IN cord-316789-nb4437qs 113 20 the the DT cord-316789-nb4437qs 113 21 virus virus NN cord-316789-nb4437qs 113 22 into into IN cord-316789-nb4437qs 113 23 the the DT cord-316789-nb4437qs 113 24 cell cell NN cord-316789-nb4437qs 113 25 or or CC cord-316789-nb4437qs 113 26 whether whether IN cord-316789-nb4437qs 113 27 viral viral JJ cord-316789-nb4437qs 113 28 genes gene NNS cord-316789-nb4437qs 113 29 responsible responsible JJ cord-316789-nb4437qs 113 30 for for IN cord-316789-nb4437qs 113 31 virus virus NN cord-316789-nb4437qs 113 32 - - HYPH cord-316789-nb4437qs 113 33 host host NN cord-316789-nb4437qs 113 34 interactions interaction NNS cord-316789-nb4437qs 113 35 also also RB cord-316789-nb4437qs 113 36 OMEL'YANCHUK OMEL'YANCHUK VBG cord-316789-nb4437qs 113 37 , , , cord-316789-nb4437qs 113 38 YUDINA YUDINA NNP cord-316789-nb4437qs 113 39 make make VBP cord-316789-nb4437qs 113 40 a a DT cord-316789-nb4437qs 113 41 contribution contribution NN cord-316789-nb4437qs 113 42 to to IN cord-316789-nb4437qs 113 43 this this DT cord-316789-nb4437qs 113 44 limitation limitation NN cord-316789-nb4437qs 113 45 . . . cord-316789-nb4437qs 114 1 The the DT cord-316789-nb4437qs 114 2 data datum NNS cord-316789-nb4437qs 114 3 consid consid NN cord-316789-nb4437qs 114 4 ered ered JJ cord-316789-nb4437qs 114 5 in in IN cord-316789-nb4437qs 114 6 this this DT cord-316789-nb4437qs 114 7 review review NN cord-316789-nb4437qs 114 8 show show NN cord-316789-nb4437qs 114 9 that that IN cord-316789-nb4437qs 114 10 viral viral JJ cord-316789-nb4437qs 114 11 genes gene NNS cord-316789-nb4437qs 114 12 of of IN cord-316789-nb4437qs 114 13 the the DT cord-316789-nb4437qs 114 14 latter latter JJ cord-316789-nb4437qs 114 15 group group NN cord-316789-nb4437qs 114 16 can can MD cord-316789-nb4437qs 114 17 act act VB cord-316789-nb4437qs 114 18 on on IN cord-316789-nb4437qs 114 19 a a DT cord-316789-nb4437qs 114 20 broad broad JJ cord-316789-nb4437qs 114 21 diversity diversity NN cord-316789-nb4437qs 114 22 of of IN cord-316789-nb4437qs 114 23 organisms organism NNS cord-316789-nb4437qs 114 24 , , , cord-316789-nb4437qs 114 25 including include VBG cord-316789-nb4437qs 114 26 Drosophila Drosophila NNP cord-316789-nb4437qs 114 27 . . . cord-316789-nb4437qs 115 1 In in IN cord-316789-nb4437qs 115 2 particular particular JJ cord-316789-nb4437qs 115 3 , , , cord-316789-nb4437qs 115 4 the the DT cord-316789-nb4437qs 115 5 Vpu Vpu NNP cord-316789-nb4437qs 115 6 protein protein NN cord-316789-nb4437qs 115 7 of of IN cord-316789-nb4437qs 115 8 HIV HIV NNP cord-316789-nb4437qs 115 9 can can MD cord-316789-nb4437qs 115 10 be be VB cord-316789-nb4437qs 115 11 phosphorylated phosphorylate VBN cord-316789-nb4437qs 115 12 in in IN cord-316789-nb4437qs 115 13 Drosophila Drosophila NNP cord-316789-nb4437qs 115 14 cells cell NNS cord-316789-nb4437qs 115 15 , , , cord-316789-nb4437qs 115 16 and and CC cord-316789-nb4437qs 115 17 the the DT cord-316789-nb4437qs 115 18 cytomega cytomega NN cord-316789-nb4437qs 115 19 lovirus lovirus NN cord-316789-nb4437qs 115 20 promoter promoter NN cord-316789-nb4437qs 115 21 ( ( -LRB- cord-316789-nb4437qs 115 22 MIEP MIEP NNP cord-316789-nb4437qs 115 23 ) ) -RRB- cord-316789-nb4437qs 115 24 functions function VBZ cord-316789-nb4437qs 115 25 only only RB cord-316789-nb4437qs 115 26 in in IN cord-316789-nb4437qs 115 27 embryonic embryonic JJ cord-316789-nb4437qs 115 28 tissues tissue NNS cord-316789-nb4437qs 115 29 of of IN cord-316789-nb4437qs 115 30 Drosophila Drosophila NNP cord-316789-nb4437qs 115 31 , , , cord-316789-nb4437qs 115 32 which which WDT cord-316789-nb4437qs 115 33 coincides coincide VBZ cord-316789-nb4437qs 115 34 with with IN cord-316789-nb4437qs 115 35 the the DT cord-316789-nb4437qs 115 36 phase phase NN cord-316789-nb4437qs 115 37 of of IN cord-316789-nb4437qs 115 38 its -PRON- PRP$ cord-316789-nb4437qs 115 39 action action NN cord-316789-nb4437qs 115 40 in in IN cord-316789-nb4437qs 115 41 mammals mammal NNS cord-316789-nb4437qs 115 42 ( ( -LRB- cord-316789-nb4437qs 115 43 see see VB cord-316789-nb4437qs 115 44 above above RB cord-316789-nb4437qs 115 45 ) ) -RRB- cord-316789-nb4437qs 115 46 . . . cord-316789-nb4437qs 116 1 These these DT cord-316789-nb4437qs 116 2 facts fact NNS cord-316789-nb4437qs 116 3 can can MD cord-316789-nb4437qs 116 4 not not RB cord-316789-nb4437qs 116 5 be be VB cord-316789-nb4437qs 116 6 accidental accidental JJ cord-316789-nb4437qs 116 7 , , , cord-316789-nb4437qs 116 8 and and CC cord-316789-nb4437qs 116 9 they -PRON- PRP cord-316789-nb4437qs 116 10 indicate indicate VBP cord-316789-nb4437qs 116 11 that that IN cord-316789-nb4437qs 116 12 the the DT cord-316789-nb4437qs 116 13 class class NN cord-316789-nb4437qs 116 14 of of IN cord-316789-nb4437qs 116 15 viral viral JJ cord-316789-nb4437qs 116 16 genes gene NNS cord-316789-nb4437qs 116 17 responsible responsible JJ cord-316789-nb4437qs 116 18 for for IN cord-316789-nb4437qs 116 19 the the DT cord-316789-nb4437qs 116 20 interaction interaction NN cord-316789-nb4437qs 116 21 of of IN cord-316789-nb4437qs 116 22 the the DT cord-316789-nb4437qs 116 23 virus virus NN cord-316789-nb4437qs 116 24 with with IN cord-316789-nb4437qs 116 25 host host NN cord-316789-nb4437qs 116 26 cells cell NNS cord-316789-nb4437qs 116 27 is be VBZ cord-316789-nb4437qs 116 28 similar similar JJ cord-316789-nb4437qs 116 29 to to IN cord-316789-nb4437qs 116 30 house house NN cord-316789-nb4437qs 116 31 keeping keep VBG cord-316789-nb4437qs 116 32 genes gene NNS cord-316789-nb4437qs 116 33 that that WDT cord-316789-nb4437qs 116 34 perform perform VBP cord-316789-nb4437qs 116 35 the the DT cord-316789-nb4437qs 116 36 same same JJ cord-316789-nb4437qs 116 37 functions function NNS cord-316789-nb4437qs 116 38 in in IN cord-316789-nb4437qs 116 39 all all DT cord-316789-nb4437qs 116 40 animals animal NNS cord-316789-nb4437qs 116 41 . . . cord-316789-nb4437qs 117 1 This this DT cord-316789-nb4437qs 117 2 means mean VBZ cord-316789-nb4437qs 117 3 that that IN cord-316789-nb4437qs 117 4 host host NN cord-316789-nb4437qs 117 5 specificity specificity NN cord-316789-nb4437qs 117 6 is be VBZ cord-316789-nb4437qs 117 7 mainly mainly RB cord-316789-nb4437qs 117 8 a a DT cord-316789-nb4437qs 117 9 result result NN cord-316789-nb4437qs 117 10 of of IN cord-316789-nb4437qs 117 11 species specie NNS cord-316789-nb4437qs 117 12 specificity specificity NN cord-316789-nb4437qs 117 13 of of IN cord-316789-nb4437qs 117 14 proteins protein NNS cord-316789-nb4437qs 117 15 responsible responsible JJ cord-316789-nb4437qs 117 16 for for IN cord-316789-nb4437qs 117 17 the the DT cord-316789-nb4437qs 117 18 penetration penetration NN cord-316789-nb4437qs 117 19 of of IN cord-316789-nb4437qs 117 20 the the DT cord-316789-nb4437qs 117 21 virus virus NN cord-316789-nb4437qs 117 22 into into IN cord-316789-nb4437qs 117 23 the the DT cord-316789-nb4437qs 117 24 cell cell NN cord-316789-nb4437qs 117 25 . . . cord-316789-nb4437qs 118 1 The the DT cord-316789-nb4437qs 118 2 range range NN cord-316789-nb4437qs 118 3 of of IN cord-316789-nb4437qs 118 4 intracellular intracellular JJ cord-316789-nb4437qs 118 5 targets target NNS cord-316789-nb4437qs 118 6 for for IN cord-316789-nb4437qs 118 7 genes gene NNS cord-316789-nb4437qs 118 8 of of IN cord-316789-nb4437qs 118 9 the the DT cord-316789-nb4437qs 118 10 second second JJ cord-316789-nb4437qs 118 11 type type NN cord-316789-nb4437qs 118 12 is be VBZ cord-316789-nb4437qs 118 13 rather rather RB cord-316789-nb4437qs 118 14 wide wide JJ cord-316789-nb4437qs 118 15 : : : cord-316789-nb4437qs 118 16 cell cell NN cord-316789-nb4437qs 118 17 apoptosis apoptosis NN cord-316789-nb4437qs 118 18 , , , cord-316789-nb4437qs 118 19 assembly assembly NN cord-316789-nb4437qs 118 20 of of IN cord-316789-nb4437qs 118 21 microtubules microtubule NNS cord-316789-nb4437qs 118 22 , , , cord-316789-nb4437qs 118 23 JNK JNK NNP cord-316789-nb4437qs 118 24 signaling signal VBG cord-316789-nb4437qs 118 25 , , , cord-316789-nb4437qs 118 26 cellular cellular JJ cord-316789-nb4437qs 118 27 immunity immunity NN cord-316789-nb4437qs 118 28 , , , cord-316789-nb4437qs 118 29 intercellular intercellular JJ cord-316789-nb4437qs 118 30 contacts contact NNS cord-316789-nb4437qs 118 31 , , , cord-316789-nb4437qs 118 32 and and CC cord-316789-nb4437qs 118 33 vesicular vesicular JJ cord-316789-nb4437qs 118 34 traffic traffic NN cord-316789-nb4437qs 118 35 . . . cord-316789-nb4437qs 119 1 It -PRON- PRP cord-316789-nb4437qs 119 2 is be VBZ cord-316789-nb4437qs 119 3 hard hard JJ cord-316789-nb4437qs 119 4 to to TO cord-316789-nb4437qs 119 5 imagine imagine VB cord-316789-nb4437qs 119 6 that that IN cord-316789-nb4437qs 119 7 this this DT cord-316789-nb4437qs 119 8 class class NN cord-316789-nb4437qs 119 9 of of IN cord-316789-nb4437qs 119 10 viral viral JJ cord-316789-nb4437qs 119 11 proteins protein NNS cord-316789-nb4437qs 119 12 influencing influence VBG cord-316789-nb4437qs 119 13 all all PDT cord-316789-nb4437qs 119 14 this this DT cord-316789-nb4437qs 119 15 diversity diversity NN cord-316789-nb4437qs 119 16 of of IN cord-316789-nb4437qs 119 17 cell cell NN cord-316789-nb4437qs 119 18 functions function NNS cord-316789-nb4437qs 119 19 occurs occur VBZ cord-316789-nb4437qs 119 20 in in IN cord-316789-nb4437qs 119 21 viruses virus NNS cord-316789-nb4437qs 119 22 de de IN cord-316789-nb4437qs 119 23 novo novo NNP cord-316789-nb4437qs 119 24 . . . cord-316789-nb4437qs 120 1 It -PRON- PRP cord-316789-nb4437qs 120 2 is be VBZ cord-316789-nb4437qs 120 3 most most RBS cord-316789-nb4437qs 120 4 likely likely JJ cord-316789-nb4437qs 120 5 that that IN cord-316789-nb4437qs 120 6 genes gene NNS cord-316789-nb4437qs 120 7 of of IN cord-316789-nb4437qs 120 8 this this DT cord-316789-nb4437qs 120 9 type type NN cord-316789-nb4437qs 120 10 are be VBP cord-316789-nb4437qs 120 11 adopted adopt VBN cord-316789-nb4437qs 120 12 by by IN cord-316789-nb4437qs 120 13 a a DT cord-316789-nb4437qs 120 14 persisting persist VBG cord-316789-nb4437qs 120 15 virus virus NN cord-316789-nb4437qs 120 16 from from IN cord-316789-nb4437qs 120 17 the the DT cord-316789-nb4437qs 120 18 host host NN cord-316789-nb4437qs 120 19 genome genome NN cord-316789-nb4437qs 120 20 , , , cord-316789-nb4437qs 120 21 as as IN cord-316789-nb4437qs 120 22 can can MD cord-316789-nb4437qs 120 23 be be VB cord-316789-nb4437qs 120 24 often often RB cord-316789-nb4437qs 120 25 seen see VBN cord-316789-nb4437qs 120 26 from from IN cord-316789-nb4437qs 120 27 homology homology NN cord-316789-nb4437qs 120 28 of of IN cord-316789-nb4437qs 120 29 the the DT cord-316789-nb4437qs 120 30 primary primary JJ cord-316789-nb4437qs 120 31 struc struc JJ cord-316789-nb4437qs 120 32 tures ture NNS cord-316789-nb4437qs 120 33 . . . cord-316789-nb4437qs 121 1 On on IN cord-316789-nb4437qs 121 2 the the DT cord-316789-nb4437qs 121 3 other other JJ cord-316789-nb4437qs 121 4 hand hand NN cord-316789-nb4437qs 121 5 , , , cord-316789-nb4437qs 121 6 the the DT cord-316789-nb4437qs 121 7 study study NN cord-316789-nb4437qs 121 8 of of IN cord-316789-nb4437qs 121 9 the the DT cord-316789-nb4437qs 121 10 functions function NNS cord-316789-nb4437qs 121 11 of of IN cord-316789-nb4437qs 121 12 viral viral JJ cord-316789-nb4437qs 121 13 proteins protein NNS cord-316789-nb4437qs 121 14 in in IN cord-316789-nb4437qs 121 15 Drosophila Drosophila NNP cord-316789-nb4437qs 121 16 can can MD cord-316789-nb4437qs 121 17 help help VB cord-316789-nb4437qs 121 18 in in IN cord-316789-nb4437qs 121 19 revealing reveal VBG cord-316789-nb4437qs 121 20 the the DT cord-316789-nb4437qs 121 21 units unit NNS cord-316789-nb4437qs 121 22 of of IN cord-316789-nb4437qs 121 23 regulation regulation NN cord-316789-nb4437qs 121 24 of of IN cord-316789-nb4437qs 121 25 intracellular intracellular JJ cord-316789-nb4437qs 121 26 processes process NNS cord-316789-nb4437qs 121 27 that that WDT cord-316789-nb4437qs 121 28 have have VBP cord-316789-nb4437qs 121 29 not not RB cord-316789-nb4437qs 121 30 yet yet RB cord-316789-nb4437qs 121 31 been be VBN cord-316789-nb4437qs 121 32 identified identify VBN cord-316789-nb4437qs 121 33 in in IN cord-316789-nb4437qs 121 34 direct direct JJ cord-316789-nb4437qs 121 35 studies study NNS cord-316789-nb4437qs 121 36 . . . cord-316789-nb4437qs 122 1 Recall recall VB cord-316789-nb4437qs 122 2 that that IN cord-316789-nb4437qs 122 3 Adamson Adamson NNP cord-316789-nb4437qs 122 4 et et NNP cord-316789-nb4437qs 122 5 al al NNP cord-316789-nb4437qs 122 6 . . . cord-316789-nb4437qs 123 1 [ [ -LRB- cord-316789-nb4437qs 123 2 26 26 CD cord-316789-nb4437qs 123 3 ] ] -RRB- cord-316789-nb4437qs 123 4 succeeded succeed VBN cord-316789-nb4437qs 123 5 in in IN cord-316789-nb4437qs 123 6 discov discov NNP cord-316789-nb4437qs 123 7 ering ering NNP cord-316789-nb4437qs 123 8 and and CC cord-316789-nb4437qs 123 9 characterizing characterize VBG cord-316789-nb4437qs 123 10 the the DT cord-316789-nb4437qs 123 11 human human JJ cord-316789-nb4437qs 123 12 virul virul NN cord-316789-nb4437qs 123 13 protein protein NN cord-316789-nb4437qs 123 14 by by IN cord-316789-nb4437qs 123 15 the the DT cord-316789-nb4437qs 123 16 methods method NNS cord-316789-nb4437qs 123 17 of of IN cord-316789-nb4437qs 123 18 molecular molecular JJ cord-316789-nb4437qs 123 19 genetics genetic NNS cord-316789-nb4437qs 123 20 of of IN cord-316789-nb4437qs 123 21 Drosophila Drosophila NNP cord-316789-nb4437qs 123 22 , , , cord-316789-nb4437qs 123 23 and and CC cord-316789-nb4437qs 123 24 , , , cord-316789-nb4437qs 123 25 pro pro JJ cord-316789-nb4437qs 123 26 ceeding ceeding NN cord-316789-nb4437qs 123 27 from from IN cord-316789-nb4437qs 123 28 the the DT cord-316789-nb4437qs 123 29 results result NNS cord-316789-nb4437qs 123 30 obtained obtain VBN cord-316789-nb4437qs 123 31 and and CC cord-316789-nb4437qs 123 32 on on IN cord-316789-nb4437qs 123 33 the the DT cord-316789-nb4437qs 123 34 basis basis NN cord-316789-nb4437qs 123 35 of of IN cord-316789-nb4437qs 123 36 homology homology NN cord-316789-nb4437qs 123 37 of of IN cord-316789-nb4437qs 123 38 the the DT cord-316789-nb4437qs 123 39 human human JJ cord-316789-nb4437qs 123 40 and and CC cord-316789-nb4437qs 123 41 Drosophila Drosophila NNP cord-316789-nb4437qs 123 42 proteins protein NNS cord-316789-nb4437qs 123 43 , , , cord-316789-nb4437qs 123 44 they -PRON- PRP cord-316789-nb4437qs 123 45 could could MD cord-316789-nb4437qs 123 46 return return VB cord-316789-nb4437qs 123 47 to to IN cord-316789-nb4437qs 123 48 studying study VBG cord-316789-nb4437qs 123 49 the the DT cord-316789-nb4437qs 123 50 action action NN cord-316789-nb4437qs 123 51 of of IN cord-316789-nb4437qs 123 52 the the DT cord-316789-nb4437qs 123 53 virus virus NN cord-316789-nb4437qs 123 54 on on IN cord-316789-nb4437qs 123 55 the the DT cord-316789-nb4437qs 123 56 human human JJ cord-316789-nb4437qs 123 57 protein protein NN cord-316789-nb4437qs 123 58 . . . cord-316789-nb4437qs 124 1 Thus thus RB cord-316789-nb4437qs 124 2 , , , cord-316789-nb4437qs 124 3 Drosophila Drosophila NNP cord-316789-nb4437qs 124 4 can can MD cord-316789-nb4437qs 124 5 be be VB cord-316789-nb4437qs 124 6 used use VBN cord-316789-nb4437qs 124 7 as as IN cord-316789-nb4437qs 124 8 an an DT cord-316789-nb4437qs 124 9 inter inter JJ cord-316789-nb4437qs 124 10 mediate mediate NN cord-316789-nb4437qs 124 11 object object NN cord-316789-nb4437qs 124 12 for for IN cord-316789-nb4437qs 124 13 studying study VBG cord-316789-nb4437qs 124 14 human human JJ cord-316789-nb4437qs 124 15 viral viral JJ cord-316789-nb4437qs 124 16 infections infection NNS cord-316789-nb4437qs 124 17 . . . cord-316789-nb4437qs 125 1 What what WDT cord-316789-nb4437qs 125 2 tasks task NNS cord-316789-nb4437qs 125 3 can can MD cord-316789-nb4437qs 125 4 be be VB cord-316789-nb4437qs 125 5 solved solve VBN cord-316789-nb4437qs 125 6 at at IN cord-316789-nb4437qs 125 7 this this DT cord-316789-nb4437qs 125 8 stage stage NN cord-316789-nb4437qs 125 9 ? ? . cord-316789-nb4437qs 126 1 First first RB cord-316789-nb4437qs 126 2 , , , cord-316789-nb4437qs 126 3 ectopic ectopic JJ cord-316789-nb4437qs 126 4 expression expression NN cord-316789-nb4437qs 126 5 of of IN cord-316789-nb4437qs 126 6 transgenes transgene NNS cord-316789-nb4437qs 126 7 in in IN cord-316789-nb4437qs 126 8 Drosophila Drosophila NNP cord-316789-nb4437qs 126 9 is be VBZ cord-316789-nb4437qs 126 10 possible possible JJ cord-316789-nb4437qs 126 11 at at IN cord-316789-nb4437qs 126 12 any any DT cord-316789-nb4437qs 126 13 stage stage NN cord-316789-nb4437qs 126 14 of of IN cord-316789-nb4437qs 126 15 development development NN cord-316789-nb4437qs 126 16 and and CC cord-316789-nb4437qs 126 17 in in IN cord-316789-nb4437qs 126 18 any any DT cord-316789-nb4437qs 126 19 tissue tissue NN cord-316789-nb4437qs 126 20 . . . cord-316789-nb4437qs 127 1 This this DT cord-316789-nb4437qs 127 2 permits permit VBZ cord-316789-nb4437qs 127 3 one one CD cord-316789-nb4437qs 127 4 to to TO cord-316789-nb4437qs 127 5 find find VB cord-316789-nb4437qs 127 6 a a DT cord-316789-nb4437qs 127 7 tissue tissue NN cord-316789-nb4437qs 127 8 and and CC cord-316789-nb4437qs 127 9 a a DT cord-316789-nb4437qs 127 10 developmental developmental JJ cord-316789-nb4437qs 127 11 stage stage NN cord-316789-nb4437qs 127 12 having have VBG cord-316789-nb4437qs 127 13 targets target NNS cord-316789-nb4437qs 127 14 for for IN cord-316789-nb4437qs 127 15 the the DT cord-316789-nb4437qs 127 16 action action NN cord-316789-nb4437qs 127 17 of of IN cord-316789-nb4437qs 127 18 viral viral JJ cord-316789-nb4437qs 127 19 proteins protein NNS cord-316789-nb4437qs 127 20 . . . cord-316789-nb4437qs 128 1 Of of RB cord-316789-nb4437qs 128 2 course course RB cord-316789-nb4437qs 128 3 , , , cord-316789-nb4437qs 128 4 there there EX cord-316789-nb4437qs 128 5 are be VBP cord-316789-nb4437qs 128 6 other other JJ cord-316789-nb4437qs 128 7 objects object NNS cord-316789-nb4437qs 128 8 more more RBR cord-316789-nb4437qs 128 9 similar similar JJ cord-316789-nb4437qs 128 10 to to IN cord-316789-nb4437qs 128 11 humans human NNS cord-316789-nb4437qs 128 12 ( ( -LRB- cord-316789-nb4437qs 128 13 e. e. NNP cord-316789-nb4437qs 128 14 g. g. NNP cord-316789-nb4437qs 128 15 , , , cord-316789-nb4437qs 128 16 mouse mouse NNP cord-316789-nb4437qs 128 17 ) ) -RRB- cord-316789-nb4437qs 128 18 that that WDT cord-316789-nb4437qs 128 19 can can MD cord-316789-nb4437qs 128 20 be be VB cord-316789-nb4437qs 128 21 used use VBN cord-316789-nb4437qs 128 22 in in IN cord-316789-nb4437qs 128 23 such such JJ cord-316789-nb4437qs 128 24 studies study NNS cord-316789-nb4437qs 128 25 , , , cord-316789-nb4437qs 128 26 but but CC cord-316789-nb4437qs 128 27 the the DT cord-316789-nb4437qs 128 28 generation generation NN cord-316789-nb4437qs 128 29 of of IN cord-316789-nb4437qs 128 30 a a DT cord-316789-nb4437qs 128 31 transgenic transgenic JJ cord-316789-nb4437qs 128 32 mouse mouse NN cord-316789-nb4437qs 128 33 is be VBZ cord-316789-nb4437qs 128 34 incomparable incomparable JJ cord-316789-nb4437qs 128 35 in in IN cord-316789-nb4437qs 128 36 costs cost NNS cord-316789-nb4437qs 128 37 with with IN cord-316789-nb4437qs 128 38 the the DT cord-316789-nb4437qs 128 39 generation generation NN cord-316789-nb4437qs 128 40 of of IN cord-316789-nb4437qs 128 41 a a DT cord-316789-nb4437qs 128 42 transgenic transgenic JJ cord-316789-nb4437qs 128 43 Drosophila Drosophila NNP cord-316789-nb4437qs 128 44 fly fly NN cord-316789-nb4437qs 128 45 . . . cord-316789-nb4437qs 129 1 Second second JJ cord-316789-nb4437qs 129 2 , , , cord-316789-nb4437qs 129 3 Drosophila Drosophila NNP cord-316789-nb4437qs 129 4 has have VBZ cord-316789-nb4437qs 129 5 an an DT cord-316789-nb4437qs 129 6 elaborate elaborate JJ cord-316789-nb4437qs 129 7 sys sys NN cord-316789-nb4437qs 129 8 tem tem NN cord-316789-nb4437qs 129 9 of of IN cord-316789-nb4437qs 129 10 genetic genetic JJ cord-316789-nb4437qs 129 11 screenings screening NNS cord-316789-nb4437qs 129 12 for for IN cord-316789-nb4437qs 129 13 discovering discover VBG cord-316789-nb4437qs 129 14 genetic genetic JJ cord-316789-nb4437qs 129 15 interac interac NN cord-316789-nb4437qs 129 16 tions tion NNS cord-316789-nb4437qs 129 17 . . . cord-316789-nb4437qs 130 1 Cases case NNS cord-316789-nb4437qs 130 2 of of IN cord-316789-nb4437qs 130 3 application application NN cord-316789-nb4437qs 130 4 of of IN cord-316789-nb4437qs 130 5 this this DT cord-316789-nb4437qs 130 6 approach approach NN cord-316789-nb4437qs 130 7 can can MD cord-316789-nb4437qs 130 8 be be VB cord-316789-nb4437qs 130 9 found find VBN cord-316789-nb4437qs 130 10 in in IN cord-316789-nb4437qs 130 11 the the DT cord-316789-nb4437qs 130 12 works work NNS cord-316789-nb4437qs 130 13 [ [ -LRB- cord-316789-nb4437qs 130 14 21 21 CD cord-316789-nb4437qs 130 15 , , , cord-316789-nb4437qs 130 16 25 25 CD cord-316789-nb4437qs 130 17 ] ] -RRB- cord-316789-nb4437qs 130 18 . . . cord-316789-nb4437qs 131 1 Genetic genetic JJ cord-316789-nb4437qs 131 2 methods method NNS cord-316789-nb4437qs 131 3 permit permit VBP cord-316789-nb4437qs 131 4 a a DT cord-316789-nb4437qs 131 5 more more RBR cord-316789-nb4437qs 131 6 complete complete JJ cord-316789-nb4437qs 131 7 characterization characterization NN cord-316789-nb4437qs 131 8 of of IN cord-316789-nb4437qs 131 9 the the DT cord-316789-nb4437qs 131 10 spectrum spectrum NN cord-316789-nb4437qs 131 11 of of IN cord-316789-nb4437qs 131 12 targets target NNS cord-316789-nb4437qs 131 13 for for IN cord-316789-nb4437qs 131 14 the the DT cord-316789-nb4437qs 131 15 action action NN cord-316789-nb4437qs 131 16 of of IN cord-316789-nb4437qs 131 17 viral viral JJ cord-316789-nb4437qs 131 18 proteins protein NNS cord-316789-nb4437qs 131 19 . . . cord-316789-nb4437qs 132 1 They -PRON- PRP cord-316789-nb4437qs 132 2 also also RB cord-316789-nb4437qs 132 3 make make VBP cord-316789-nb4437qs 132 4 it -PRON- PRP cord-316789-nb4437qs 132 5 possible possible JJ cord-316789-nb4437qs 132 6 to to TO cord-316789-nb4437qs 132 7 discover discover VB cord-316789-nb4437qs 132 8 weak weak JJ cord-316789-nb4437qs 132 9 interactions interaction NNS cord-316789-nb4437qs 132 10 that that WDT cord-316789-nb4437qs 132 11 can can MD cord-316789-nb4437qs 132 12 be be VB cord-316789-nb4437qs 132 13 revealed reveal VBN cord-316789-nb4437qs 132 14 only only RB cord-316789-nb4437qs 132 15 by by IN cord-316789-nb4437qs 132 16 the the DT cord-316789-nb4437qs 132 17 modern modern JJ cord-316789-nb4437qs 132 18 methods method NNS cord-316789-nb4437qs 132 19 detecting detect VBG cord-316789-nb4437qs 132 20 physical physical JJ cord-316789-nb4437qs 132 21 binding binding NN cord-316789-nb4437qs 132 22 of of IN cord-316789-nb4437qs 132 23 mac mac NNP cord-316789-nb4437qs 132 24 romolecules romolecule NNS cord-316789-nb4437qs 132 25 . . . cord-316789-nb4437qs 133 1 Around around IN cord-316789-nb4437qs 133 2 the the DT cord-316789-nb4437qs 133 3 Genomes genome NNS cord-316789-nb4437qs 133 4 : : : cord-316789-nb4437qs 133 5 The the DT cord-316789-nb4437qs 133 6 Drosophila Drosophila NNP cord-316789-nb4437qs 133 7 Genome Genome NNP cord-316789-nb4437qs 133 8 Project Project NNP cord-316789-nb4437qs 133 9 Developmental Developmental NNP cord-316789-nb4437qs 133 10 Control Control NNP cord-316789-nb4437qs 133 11 of of IN cord-316789-nb4437qs 133 12 Cell Cell NNP cord-316789-nb4437qs 133 13 Cycle Cycle NNP cord-316789-nb4437qs 133 14 Regulators regulator NNS cord-316789-nb4437qs 133 15 : : : cord-316789-nb4437qs 134 1 A a DT cord-316789-nb4437qs 134 2 Fly fly NN cord-316789-nb4437qs 134 3 's 's POS cord-316789-nb4437qs 135 1 Perspective perspective VB cord-316789-nb4437qs 135 2 A a DT cord-316789-nb4437qs 135 3 Systematic Systematic NNP cord-316789-nb4437qs 135 4 Analysis Analysis NNP cord-316789-nb4437qs 135 5 of of IN cord-316789-nb4437qs 135 6 Human Human NNP cord-316789-nb4437qs 135 7 Disease Disease NNP cord-316789-nb4437qs 135 8 Associated Associated NNP cord-316789-nb4437qs 135 9 Gene Gene NNP cord-316789-nb4437qs 135 10 Sequences Sequences NNPS cord-316789-nb4437qs 135 11 in in IN cord-316789-nb4437qs 135 12 Drosophila Drosophila NNP cord-316789-nb4437qs 135 13 melanogaster melanogaster NN cord-316789-nb4437qs 135 14 Transposable Transposable NNP cord-316789-nb4437qs 135 15 Elements Elements NNP cord-316789-nb4437qs 135 16 as as IN cord-316789-nb4437qs 135 17 Tools Tools NNPS cord-316789-nb4437qs 135 18 for for IN cord-316789-nb4437qs 135 19 Genomics Genomics NNPS cord-316789-nb4437qs 135 20 and and CC cord-316789-nb4437qs 135 21 Genetics Genetics NNP cord-316789-nb4437qs 135 22 in in IN cord-316789-nb4437qs 135 23 Drosophila Drosophila NNP cord-316789-nb4437qs 135 24 Targeted Targeted NNP cord-316789-nb4437qs 135 25 Gene Gene NNP cord-316789-nb4437qs 135 26 Expres Expres NNP cord-316789-nb4437qs 135 27 sion sion NN cord-316789-nb4437qs 135 28 as as IN cord-316789-nb4437qs 135 29 a a DT cord-316789-nb4437qs 135 30 Means means NN cord-316789-nb4437qs 135 31 of of IN cord-316789-nb4437qs 135 32 Altering alter VBG cord-316789-nb4437qs 135 33 Cell cell NN cord-316789-nb4437qs 135 34 Fates Fates NNPS cord-316789-nb4437qs 135 35 and and CC cord-316789-nb4437qs 135 36 Generating generate VBG cord-316789-nb4437qs 135 37 Dominant Dominant NNP cord-316789-nb4437qs 135 38 Phenotypes Phenotypes NNP cord-316789-nb4437qs 135 39 Large large JJ cord-316789-nb4437qs 135 40 Scale scale NN cord-316789-nb4437qs 135 41 Sequencing Sequencing NNP cord-316789-nb4437qs 135 42 of of IN cord-316789-nb4437qs 135 43 Human Human NNP cord-316789-nb4437qs 135 44 Influenza Influenza NNP cord-316789-nb4437qs 135 45 Reveals reveal VBZ cord-316789-nb4437qs 135 46 the the DT cord-316789-nb4437qs 135 47 Dynamic dynamic JJ cord-316789-nb4437qs 135 48 Nature nature NN cord-316789-nb4437qs 135 49 of of IN cord-316789-nb4437qs 135 50 Viral Viral NNP cord-316789-nb4437qs 135 51 Genome Genome NNP cord-316789-nb4437qs 135 52 Evolution evolution NN cord-316789-nb4437qs 136 1 The the DT cord-316789-nb4437qs 136 2 y134 y134 NN cord-316789-nb4437qs 136 3 . . . cord-316789-nb4437qs 137 1 5 5 CD cord-316789-nb4437qs 137 2 Gene Gene NNP cord-316789-nb4437qs 137 3 of of IN cord-316789-nb4437qs 137 4 Herpes Herpes NNP cord-316789-nb4437qs 137 5 Simplex Simplex NNP cord-316789-nb4437qs 137 6 Virus Virus NNP cord-316789-nb4437qs 137 7 1 1 CD cord-316789-nb4437qs 137 8 Precludes preclude VBZ cord-316789-nb4437qs 137 9 Neuroblastoma neuroblastoma NN cord-316789-nb4437qs 137 10 Cells cell NNS cord-316789-nb4437qs 137 11 from from IN cord-316789-nb4437qs 137 12 Triggering trigger VBG cord-316789-nb4437qs 137 13 Total total JJ cord-316789-nb4437qs 137 14 Shutoff Shutoff NNP cord-316789-nb4437qs 137 15 of of IN cord-316789-nb4437qs 137 16 Protein Protein NNP cord-316789-nb4437qs 137 17 Synthesis Synthesis NNP cord-316789-nb4437qs 137 18 Characteris Characteris NNP cord-316789-nb4437qs 137 19 tic tic NN cord-316789-nb4437qs 137 20 of of IN cord-316789-nb4437qs 137 21 Programmed programmed JJ cord-316789-nb4437qs 137 22 Cell Cell NNP cord-316789-nb4437qs 137 23 Death death NN cord-316789-nb4437qs 137 24 in in IN cord-316789-nb4437qs 137 25 Neuronal Neuronal NNP cord-316789-nb4437qs 137 26 Cells Cells NNPS cord-316789-nb4437qs 137 27 Prevention Prevention NNP cord-316789-nb4437qs 137 28 of of IN cord-316789-nb4437qs 137 29 Apoptosis Apoptosis NNP cord-316789-nb4437qs 137 30 by by IN cord-316789-nb4437qs 137 31 a a DT cord-316789-nb4437qs 137 32 Baculovirus Baculovirus NNP cord-316789-nb4437qs 137 33 Gene Gene NNP cord-316789-nb4437qs 137 34 during during IN cord-316789-nb4437qs 137 35 Infection Infection NNP cord-316789-nb4437qs 137 36 of of IN cord-316789-nb4437qs 137 37 Insect Insect NNP cord-316789-nb4437qs 137 38 Cells cell NNS cord-316789-nb4437qs 138 1 An an DT cord-316789-nb4437qs 138 2 Apopto Apopto NNP cord-316789-nb4437qs 139 1 sis sis NN cord-316789-nb4437qs 139 2 Inhibiting inhibit VBG cord-316789-nb4437qs 139 3 Baculovirus Baculovirus NNP cord-316789-nb4437qs 139 4 Gene Gene NNP cord-316789-nb4437qs 139 5 with with IN cord-316789-nb4437qs 139 6 a a DT cord-316789-nb4437qs 140 1 Zinc Zinc NNP cord-316789-nb4437qs 140 2 Finger Finger NNP cord-316789-nb4437qs 140 3 Like like IN cord-316789-nb4437qs 140 4 Motif Motif NNP cord-316789-nb4437qs 140 5 Induction Induction NNP cord-316789-nb4437qs 140 6 of of IN cord-316789-nb4437qs 140 7 bcl bcl NNP cord-316789-nb4437qs 140 8 2 2 CD cord-316789-nb4437qs 140 9 Expression expression NN cord-316789-nb4437qs 140 10 by by IN cord-316789-nb4437qs 140 11 Epstein Epstein NNP cord-316789-nb4437qs 140 12 Barr Barr NNP cord-316789-nb4437qs 140 13 Virus Virus NNP cord-316789-nb4437qs 140 14 Latent Latent NNP cord-316789-nb4437qs 140 15 Mem Mem NNP cord-316789-nb4437qs 140 16 brane brane NN cord-316789-nb4437qs 140 17 Protein protein NN cord-316789-nb4437qs 140 18 1 1 CD cord-316789-nb4437qs 141 1 Protects protect VBZ cord-316789-nb4437qs 141 2 Infected infect VBN cord-316789-nb4437qs 141 3 B b NN cord-316789-nb4437qs 141 4 Cells cell NNS cord-316789-nb4437qs 141 5 from from IN cord-316789-nb4437qs 141 6 Pro pro JJ cord-316789-nb4437qs 141 7 grammed grammed NN cord-316789-nb4437qs 142 1 Cell cell NN cord-316789-nb4437qs 142 2 Death Death NNP cord-316789-nb4437qs 142 3 Epstein Epstein NNP cord-316789-nb4437qs 142 4 - - HYPH cord-316789-nb4437qs 142 5 Barr Barr NNP cord-316789-nb4437qs 142 6 Virus Virus NNP cord-316789-nb4437qs 142 7 Coded code VBD cord-316789-nb4437qs 142 8 BHRF1 BHRF1 NNP cord-316789-nb4437qs 142 9 Protein Protein NNP cord-316789-nb4437qs 142 10 , , , cord-316789-nb4437qs 142 11 a a DT cord-316789-nb4437qs 142 12 Viral Viral NNP cord-316789-nb4437qs 142 13 Homologue Homologue NNP cord-316789-nb4437qs 142 14 of of IN cord-316789-nb4437qs 142 15 Bcl Bcl NNP cord-316789-nb4437qs 142 16 2 2 CD cord-316789-nb4437qs 142 17 , , , cord-316789-nb4437qs 142 18 Protects protect VBZ cord-316789-nb4437qs 142 19 Human Human NNP cord-316789-nb4437qs 142 20 B B NNP cord-316789-nb4437qs 142 21 Cells cell NNS cord-316789-nb4437qs 142 22 from from IN cord-316789-nb4437qs 142 23 Programmed programmed JJ cord-316789-nb4437qs 142 24 Cell cell NN cord-316789-nb4437qs 142 25 Death death NN cord-316789-nb4437qs 143 1 The the DT cord-316789-nb4437qs 143 2 19 19 CD cord-316789-nb4437qs 143 3 Kilodalton Kilodalton NNP cord-316789-nb4437qs 143 4 Adenovirus Adenovirus NNP cord-316789-nb4437qs 143 5 E1B E1B NNS cord-316789-nb4437qs 143 6 Transforming transform VBG cord-316789-nb4437qs 143 7 Protein Protein NNP cord-316789-nb4437qs 143 8 Inhibits inhibit VBZ cord-316789-nb4437qs 143 9 Programmed program VBN cord-316789-nb4437qs 143 10 Cell cell NN cord-316789-nb4437qs 143 11 Death death NN cord-316789-nb4437qs 143 12 and and CC cord-316789-nb4437qs 143 13 Prevents prevent VBZ cord-316789-nb4437qs 143 14 Cytoly Cytoly NNP cord-316789-nb4437qs 143 15 sis sis NN cord-316789-nb4437qs 143 16 by by IN cord-316789-nb4437qs 144 1 Tumor tumor NN cord-316789-nb4437qs 144 2 Necrosis necrosis NN cord-316789-nb4437qs 144 3 Factor Factor NNP cord-316789-nb4437qs 144 4 Alpha Alpha NNP cord-316789-nb4437qs 144 5 A a DT cord-316789-nb4437qs 144 6 14.700 14.700 CD cord-316789-nb4437qs 144 7 MW MW NNP cord-316789-nb4437qs 144 8 Protein Protein NNP cord-316789-nb4437qs 144 9 from from IN cord-316789-nb4437qs 144 10 the the DT cord-316789-nb4437qs 144 11 E3 E3 NNP cord-316789-nb4437qs 144 12 Region Region NNP cord-316789-nb4437qs 144 13 of of IN cord-316789-nb4437qs 144 14 Adenovirus Adenovirus NNP cord-316789-nb4437qs 144 15 Inhibits inhibit VBZ cord-316789-nb4437qs 144 16 Cytolysis Cytolysis NNP cord-316789-nb4437qs 144 17 by by IN cord-316789-nb4437qs 144 18 Tumor tumor NN cord-316789-nb4437qs 144 19 Necrosis necrosis NN cord-316789-nb4437qs 144 20 Factor factor NN cord-316789-nb4437qs 145 1 The the DT cord-316789-nb4437qs 145 2 10.400 10.400 CD cord-316789-nb4437qs 145 3 and and CC cord-316789-nb4437qs 145 4 14.500 14.500 CD cord-316789-nb4437qs 145 5 Dalton Dalton NNP cord-316789-nb4437qs 145 6 Proteins Proteins NNP cord-316789-nb4437qs 145 7 Encoded encode VBN cord-316789-nb4437qs 145 8 by by IN cord-316789-nb4437qs 145 9 Region Region NNP cord-316789-nb4437qs 145 10 E3 E3 NNP cord-316789-nb4437qs 145 11 of of IN cord-316789-nb4437qs 145 12 Adenovirus Adenovirus NNP cord-316789-nb4437qs 145 13 Function Function NNP cord-316789-nb4437qs 146 1 Together together RB cord-316789-nb4437qs 146 2 to to TO cord-316789-nb4437qs 146 3 Protect protect VB cord-316789-nb4437qs 146 4 Many many JJ cord-316789-nb4437qs 146 5 but but CC cord-316789-nb4437qs 146 6 not not RB cord-316789-nb4437qs 146 7 All all DT cord-316789-nb4437qs 146 8 Mouse Mouse NNP cord-316789-nb4437qs 146 9 Cell Cell NNP cord-316789-nb4437qs 146 10 Lines line NNS cord-316789-nb4437qs 146 11 Against against IN cord-316789-nb4437qs 146 12 Lysis lysis NN cord-316789-nb4437qs 146 13 by by IN cord-316789-nb4437qs 146 14 Tumor tumor NN cord-316789-nb4437qs 146 15 Necrosis necrosis NN cord-316789-nb4437qs 146 16 Factor factor NN cord-316789-nb4437qs 147 1 The the DT cord-316789-nb4437qs 147 2 E1B E1B NNS cord-316789-nb4437qs 147 3 19 19 CD cord-316789-nb4437qs 147 4 K K NNP cord-316789-nb4437qs 147 5 Protein Protein NNP cord-316789-nb4437qs 147 6 of of IN cord-316789-nb4437qs 147 7 Group Group NNP cord-316789-nb4437qs 147 8 C C NNP cord-316789-nb4437qs 147 9 Adenoviruses adenovirus NNS cord-316789-nb4437qs 147 10 Prevents prevent VBZ cord-316789-nb4437qs 147 11 Cytolysis Cytolysis NNP cord-316789-nb4437qs 147 12 by by IN cord-316789-nb4437qs 147 13 Tumor tumor NN cord-316789-nb4437qs 147 14 Necrosis necrosis NN cord-316789-nb4437qs 147 15 Factor factor NN cord-316789-nb4437qs 147 16 of of IN cord-316789-nb4437qs 147 17 Human Human NNP cord-316789-nb4437qs 147 18 Cells Cells NNPS cord-316789-nb4437qs 147 19 but but CC cord-316789-nb4437qs 147 20 not not RB cord-316789-nb4437qs 147 21 Mouse mouse NN cord-316789-nb4437qs 147 22 Cells Cells NNP cord-316789-nb4437qs 147 23 Expression expression NN cord-316789-nb4437qs 147 24 of of IN cord-316789-nb4437qs 147 25 Baculovirus Baculovirus NNP cord-316789-nb4437qs 147 26 P35 P35 NNP cord-316789-nb4437qs 147 27 Prevents prevent VBZ cord-316789-nb4437qs 147 28 Cell cell NN cord-316789-nb4437qs 147 29 Death death NN cord-316789-nb4437qs 147 30 in in IN cord-316789-nb4437qs 147 31 Drosophila Drosophila NNP cord-316789-nb4437qs 147 32 Programmed program VBN cord-316789-nb4437qs 147 33 Cell Cell NNP cord-316789-nb4437qs 147 34 Death death NN cord-316789-nb4437qs 147 35 during during IN cord-316789-nb4437qs 147 36 Drosophila Drosophila NNP cord-316789-nb4437qs 147 37 Embryo Embryo NNP cord-316789-nb4437qs 147 38 genesis genesis NN cord-316789-nb4437qs 147 39 A a DT cord-316789-nb4437qs 147 40 Drosophila Drosophila NNP cord-316789-nb4437qs 147 41 Model Model NNP cord-316789-nb4437qs 147 42 of of IN cord-316789-nb4437qs 147 43 HIV HIV NNP cord-316789-nb4437qs 147 44 Tat Tat NNP cord-316789-nb4437qs 147 45 Related Related NNP cord-316789-nb4437qs 147 46 Pathogenicity Pathogenicity NNP cord-316789-nb4437qs 147 47 Mechanism Mechanism NNP cord-316789-nb4437qs 147 48 of of IN cord-316789-nb4437qs 147 49 HIV HIV NNP cord-316789-nb4437qs 147 50 1 1 CD cord-316789-nb4437qs 147 51 Tat Tat NNP cord-316789-nb4437qs 147 52 RNA RNA NNP cord-316789-nb4437qs 147 53 Translation Translation NNP cord-316789-nb4437qs 147 54 and and CC cord-316789-nb4437qs 147 55 Its -PRON- PRP$ cord-316789-nb4437qs 147 56 Activation activation NN cord-316789-nb4437qs 147 57 by by IN cord-316789-nb4437qs 147 58 the the DT cord-316789-nb4437qs 147 59 Tat Tat NNP cord-316789-nb4437qs 147 60 Protein Protein NNP cord-316789-nb4437qs 147 61 Nef Nef NNP cord-316789-nb4437qs 148 1 Induces induce VBZ cord-316789-nb4437qs 148 2 Apoptosis Apoptosis NNP cord-316789-nb4437qs 148 3 by by IN cord-316789-nb4437qs 148 4 Activating activate VBG cord-316789-nb4437qs 148 5 JNK JNK NNP cord-316789-nb4437qs 148 6 Signaling Signaling NNP cord-316789-nb4437qs 148 7 Pathway Pathway NNP cord-316789-nb4437qs 148 8 and and CC cord-316789-nb4437qs 148 9 Inhibits inhibit VBZ cord-316789-nb4437qs 148 10 NF NF NNP cord-316789-nb4437qs 148 11 B B NNP cord-316789-nb4437qs 148 12 Dependent Dependent NNP cord-316789-nb4437qs 148 13 Immune Immune NNP cord-316789-nb4437qs 148 14 Responses response NNS cord-316789-nb4437qs 148 15 in in IN cord-316789-nb4437qs 148 16 Droso Droso NNP cord-316789-nb4437qs 148 17 phila phila NNP cord-316789-nb4437qs 148 18 Directed direct VBD cord-316789-nb4437qs 148 19 Expression Expression NNP cord-316789-nb4437qs 148 20 of of IN cord-316789-nb4437qs 148 21 the the DT cord-316789-nb4437qs 148 22 HIV HIV NNP cord-316789-nb4437qs 148 23 1 1 CD cord-316789-nb4437qs 148 24 Accessory Accessory NNP cord-316789-nb4437qs 148 25 Protein Protein NNP cord-316789-nb4437qs 148 26 Vpu Vpu NNP cord-316789-nb4437qs 148 27 in in IN cord-316789-nb4437qs 148 28 Drosophila drosophila JJ cord-316789-nb4437qs 148 29 Fat fat JJ cord-316789-nb4437qs 148 30 Body body NN cord-316789-nb4437qs 148 31 Cells cell NNS cord-316789-nb4437qs 148 32 Inhibits inhibit VBZ cord-316789-nb4437qs 149 1 Toll toll NN cord-316789-nb4437qs 149 2 Dependent dependent JJ cord-316789-nb4437qs 149 3 Immune immune JJ cord-316789-nb4437qs 149 4 Responses response NNS cord-316789-nb4437qs 150 1 Two two CD cord-316789-nb4437qs 150 2 Distinct distinct JJ cord-316789-nb4437qs 150 3 Pathways pathway NNS cord-316789-nb4437qs 150 4 Can Can MD cord-316789-nb4437qs 150 5 Control control VB cord-316789-nb4437qs 150 6 Expression expression NN cord-316789-nb4437qs 150 7 of of IN cord-316789-nb4437qs 150 8 the the DT cord-316789-nb4437qs 150 9 Drosophila Drosophila NNP cord-316789-nb4437qs 150 10 Antimicrobial Antimicrobial NNP cord-316789-nb4437qs 150 11 Peptide Peptide NNP cord-316789-nb4437qs 150 12 Metchnikowin Metchnikowin NNP cord-316789-nb4437qs 150 13 Drosophila Drosophila NNP cord-316789-nb4437qs 150 14 melano melano NN cord-316789-nb4437qs 150 15 gaster gaster NN cord-316789-nb4437qs 150 16 as as IN cord-316789-nb4437qs 150 17 a a DT cord-316789-nb4437qs 150 18 Complementary Complementary NNP cord-316789-nb4437qs 150 19 System System NNP cord-316789-nb4437qs 150 20 for for IN cord-316789-nb4437qs 150 21 Studying study VBG cord-316789-nb4437qs 150 22 HIV HIV NNP cord-316789-nb4437qs 150 23 1 1 CD cord-316789-nb4437qs 150 24 Related Related NNP cord-316789-nb4437qs 150 25 Genes Genes NNPS cord-316789-nb4437qs 150 26 and and CC cord-316789-nb4437qs 150 27 Proteins protein NNS cord-316789-nb4437qs 151 1 In in IN cord-316789-nb4437qs 151 2 vivo vivo NN cord-316789-nb4437qs 151 3 Func Func NNP cord-316789-nb4437qs 151 4 tional tional NN cord-316789-nb4437qs 151 5 Characterization characterization NN cord-316789-nb4437qs 151 6 of of IN cord-316789-nb4437qs 151 7 the the DT cord-316789-nb4437qs 151 8 SARS SARS NNP cord-316789-nb4437qs 151 9 Coronavirus Coronavirus NNP cord-316789-nb4437qs 151 10 3a 3a CD cord-316789-nb4437qs 151 11 Protein Protein NNP cord-316789-nb4437qs 151 12 in in IN cord-316789-nb4437qs 151 13 Drosophila Drosophila NNP cord-316789-nb4437qs 151 14 Modeling Modeling NNP cord-316789-nb4437qs 152 1 Early early JJ cord-316789-nb4437qs 152 2 Epstein Epstein NNP cord-316789-nb4437qs 152 3 - - HYPH cord-316789-nb4437qs 152 4 Barr Barr NNP cord-316789-nb4437qs 152 5 Virus Virus NNP cord-316789-nb4437qs 152 6 Infection Infection NNP cord-316789-nb4437qs 152 7 in in IN cord-316789-nb4437qs 152 8 Droso Droso NNP cord-316789-nb4437qs 152 9 phila phila NNP cord-316789-nb4437qs 152 10 melanogaster melanogaster NN cord-316789-nb4437qs 152 11 : : : cord-316789-nb4437qs 153 1 The the DT cord-316789-nb4437qs 153 2 BZLF1 BZLF1 NNP cord-316789-nb4437qs 154 1 Protein protein NN cord-316789-nb4437qs 154 2 Outcome outcome NN cord-316789-nb4437qs 154 3 of of IN cord-316789-nb4437qs 154 4 Symptomatic symptomatic JJ cord-316789-nb4437qs 154 5 Congenital congenital JJ cord-316789-nb4437qs 154 6 Cytomegalovirus Cytomegalovirus NNP cord-316789-nb4437qs 154 7 Infection infection NN cord-316789-nb4437qs 154 8 , , , cord-316789-nb4437qs 154 9 Results result NNS cord-316789-nb4437qs 154 10 of of IN cord-316789-nb4437qs 154 11 Long Long NNP cord-316789-nb4437qs 154 12 Term Term NNP cord-316789-nb4437qs 154 13 Longitudinal longitudinal JJ cord-316789-nb4437qs 154 14 Follow follow VB cord-316789-nb4437qs 154 15 Up up RP cord-316789-nb4437qs 155 1 Human Human NNP cord-316789-nb4437qs 155 2 Cytomegalovirus Cytomegalovirus NNP cord-316789-nb4437qs 155 3 Immedi Immedi NNP cord-316789-nb4437qs 155 4 ate eat VBD cord-316789-nb4437qs 155 5 Early early JJ cord-316789-nb4437qs 155 6 Gene Gene NNP cord-316789-nb4437qs 155 7 Expression expression NN cord-316789-nb4437qs 155 8 Disrupts disrupt VBZ cord-316789-nb4437qs 155 9 Embryogenesis embryogenesis NN cord-316789-nb4437qs 155 10 in in IN cord-316789-nb4437qs 155 11 Transgenic transgenic JJ cord-316789-nb4437qs 155 12 Drosophila Drosophila NNP cord-316789-nb4437qs 155 13 Understanding understanding NN cord-316789-nb4437qs 155 14 Viruses virus NNS